id sid tid token lemma pos cord-281487-x0a9qgjs 1 1 key key JJ cord-281487-x0a9qgjs 1 2 : : : cord-281487-x0a9qgjs 1 3 cord-281487-x0a9qgjs cord-281487-x0a9qgjs CD cord-281487-x0a9qgjs 1 4 authors author NNS cord-281487-x0a9qgjs 1 5 : : : cord-281487-x0a9qgjs 1 6 Kim Kim NNP cord-281487-x0a9qgjs 1 7 , , , cord-281487-x0a9qgjs 1 8 Min Min NNP cord-281487-x0a9qgjs 1 9 Young Young NNP cord-281487-x0a9qgjs 1 10 ; ; : cord-281487-x0a9qgjs 1 11 Brennan Brennan NNP cord-281487-x0a9qgjs 1 12 , , , cord-281487-x0a9qgjs 1 13 Daniel Daniel NNP cord-281487-x0a9qgjs 1 14 C. C. NNP cord-281487-x0a9qgjs 1 15 ; ; : cord-281487-x0a9qgjs 1 16 Shah Shah NNP cord-281487-x0a9qgjs 1 17 , , , cord-281487-x0a9qgjs 1 18 Pali Pali NNP cord-281487-x0a9qgjs 1 19 title title NN cord-281487-x0a9qgjs 1 20 : : : cord-281487-x0a9qgjs 1 21 General General NNP cord-281487-x0a9qgjs 1 22 Approach Approach NNP cord-281487-x0a9qgjs 1 23 to to IN cord-281487-x0a9qgjs 1 24 the the DT cord-281487-x0a9qgjs 1 25 Clinical Clinical NNP cord-281487-x0a9qgjs 1 26 Care Care NNP cord-281487-x0a9qgjs 1 27 of of IN cord-281487-x0a9qgjs 1 28 Solid Solid NNP cord-281487-x0a9qgjs 1 29 Organ Organ NNP cord-281487-x0a9qgjs 1 30 Transplant Transplant NNP cord-281487-x0a9qgjs 1 31 Recipients recipient NNS cord-281487-x0a9qgjs 1 32 with with IN cord-281487-x0a9qgjs 2 1 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 2 2 Infection Infection NNP cord-281487-x0a9qgjs 2 3 : : : cord-281487-x0a9qgjs 2 4 Management management NN cord-281487-x0a9qgjs 2 5 for for IN cord-281487-x0a9qgjs 2 6 Transplant Transplant NNP cord-281487-x0a9qgjs 2 7 Recipients Recipients NNP cord-281487-x0a9qgjs 2 8 date date NN cord-281487-x0a9qgjs 2 9 : : : cord-281487-x0a9qgjs 2 10 2020 2020 CD cord-281487-x0a9qgjs 2 11 - - SYM cord-281487-x0a9qgjs 2 12 10 10 CD cord-281487-x0a9qgjs 2 13 - - SYM cord-281487-x0a9qgjs 2 14 29 29 CD cord-281487-x0a9qgjs 2 15 journal journal NN cord-281487-x0a9qgjs 2 16 : : : cord-281487-x0a9qgjs 2 17 Curr Curr NNP cord-281487-x0a9qgjs 2 18 Transplant Transplant NNP cord-281487-x0a9qgjs 2 19 Rep Rep NNP cord-281487-x0a9qgjs 2 20 DOI DOI NNP cord-281487-x0a9qgjs 2 21 : : : cord-281487-x0a9qgjs 2 22 10.1007 10.1007 CD cord-281487-x0a9qgjs 3 1 /s40472 /s40472 NNP cord-281487-x0a9qgjs 3 2 - - : cord-281487-x0a9qgjs 3 3 020 020 CD cord-281487-x0a9qgjs 4 1 -00305-y -00305-y RB cord-281487-x0a9qgjs 5 1 sha sha NNP cord-281487-x0a9qgjs 5 2 : : : cord-281487-x0a9qgjs 6 1 378db8927c28cc6b2e15a709c85d771eddee2fbe 378db8927c28cc6b2e15a709c85d771eddee2fbe NNP cord-281487-x0a9qgjs 6 2 doc_id doc_id CD cord-281487-x0a9qgjs 6 3 : : : cord-281487-x0a9qgjs 6 4 281487 281487 CD cord-281487-x0a9qgjs 6 5 cord_uid cord_uid NNS cord-281487-x0a9qgjs 6 6 : : : cord-281487-x0a9qgjs 6 7 x0a9qgjs x0a9qgjs LS cord-281487-x0a9qgjs 6 8 PURPOSE purpose NN cord-281487-x0a9qgjs 6 9 OF of IN cord-281487-x0a9qgjs 6 10 REVIEW review NN cord-281487-x0a9qgjs 6 11 : : : cord-281487-x0a9qgjs 7 1 Insufficient insufficient JJ cord-281487-x0a9qgjs 7 2 knowledge knowledge NN cord-281487-x0a9qgjs 7 3 about about IN cord-281487-x0a9qgjs 7 4 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 7 5 and and CC cord-281487-x0a9qgjs 7 6 the the DT cord-281487-x0a9qgjs 7 7 potential potential JJ cord-281487-x0a9qgjs 7 8 risks risk NNS cord-281487-x0a9qgjs 7 9 of of IN cord-281487-x0a9qgjs 7 10 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 7 11 are be VBP cord-281487-x0a9qgjs 7 12 limiting limit VBG cord-281487-x0a9qgjs 7 13 organ organ NN cord-281487-x0a9qgjs 7 14 transplantation transplantation NN cord-281487-x0a9qgjs 7 15 in in IN cord-281487-x0a9qgjs 7 16 wait wait NN cord-281487-x0a9qgjs 7 17 - - HYPH cord-281487-x0a9qgjs 7 18 listed list VBN cord-281487-x0a9qgjs 7 19 candidates candidate NNS cord-281487-x0a9qgjs 7 20 and and CC cord-281487-x0a9qgjs 7 21 deferring defer VBG cord-281487-x0a9qgjs 7 22 essential essential JJ cord-281487-x0a9qgjs 7 23 health health NN cord-281487-x0a9qgjs 7 24 care care NN cord-281487-x0a9qgjs 7 25 in in IN cord-281487-x0a9qgjs 7 26 solid solid JJ cord-281487-x0a9qgjs 7 27 organ organ NN cord-281487-x0a9qgjs 7 28 transplant transplant NN cord-281487-x0a9qgjs 7 29 recipients recipient NNS cord-281487-x0a9qgjs 7 30 . . . cord-281487-x0a9qgjs 8 1 In in IN cord-281487-x0a9qgjs 8 2 this this DT cord-281487-x0a9qgjs 8 3 review review NN cord-281487-x0a9qgjs 8 4 , , , cord-281487-x0a9qgjs 8 5 we -PRON- PRP cord-281487-x0a9qgjs 8 6 expand expand VBP cord-281487-x0a9qgjs 8 7 the the DT cord-281487-x0a9qgjs 8 8 understanding understanding NN cord-281487-x0a9qgjs 8 9 and and CC cord-281487-x0a9qgjs 8 10 present present VB cord-281487-x0a9qgjs 8 11 an an DT cord-281487-x0a9qgjs 8 12 overview overview NN cord-281487-x0a9qgjs 8 13 of of IN cord-281487-x0a9qgjs 8 14 the the DT cord-281487-x0a9qgjs 8 15 optimized optimize VBN cord-281487-x0a9qgjs 8 16 management management NN cord-281487-x0a9qgjs 8 17 of of IN cord-281487-x0a9qgjs 8 18 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 8 19 in in IN cord-281487-x0a9qgjs 8 20 solid solid JJ cord-281487-x0a9qgjs 8 21 organ organ NN cord-281487-x0a9qgjs 8 22 transplant transplant NN cord-281487-x0a9qgjs 8 23 recipients recipient NNS cord-281487-x0a9qgjs 8 24 . . . cord-281487-x0a9qgjs 9 1 RECENT recent JJ cord-281487-x0a9qgjs 9 2 FINDINGS finding NNS cord-281487-x0a9qgjs 9 3 : : : cord-281487-x0a9qgjs 10 1 Transplant transplant NN cord-281487-x0a9qgjs 10 2 recipients recipient NNS cord-281487-x0a9qgjs 10 3 are be VBP cord-281487-x0a9qgjs 10 4 at at IN cord-281487-x0a9qgjs 10 5 an an DT cord-281487-x0a9qgjs 10 6 increased increase VBN cord-281487-x0a9qgjs 10 7 risk risk NN cord-281487-x0a9qgjs 10 8 of of IN cord-281487-x0a9qgjs 10 9 severe severe JJ cord-281487-x0a9qgjs 10 10 COVID-19 covid-19 NN cord-281487-x0a9qgjs 10 11 . . . cord-281487-x0a9qgjs 11 1 The the DT cord-281487-x0a9qgjs 11 2 unique unique JJ cord-281487-x0a9qgjs 11 3 characteristics characteristic NNS cord-281487-x0a9qgjs 11 4 of of IN cord-281487-x0a9qgjs 11 5 transplant transplant NN cord-281487-x0a9qgjs 11 6 recipients recipient NNS cord-281487-x0a9qgjs 11 7 can can MD cord-281487-x0a9qgjs 11 8 make make VB cord-281487-x0a9qgjs 11 9 it -PRON- PRP cord-281487-x0a9qgjs 11 10 more more RBR cord-281487-x0a9qgjs 11 11 difficult difficult JJ cord-281487-x0a9qgjs 11 12 to to TO cord-281487-x0a9qgjs 11 13 identify identify VB cord-281487-x0a9qgjs 11 14 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 11 15 . . . cord-281487-x0a9qgjs 12 1 Based base VBN cord-281487-x0a9qgjs 12 2 on on IN cord-281487-x0a9qgjs 12 3 the the DT cord-281487-x0a9qgjs 12 4 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 12 5 data datum NNS cord-281487-x0a9qgjs 12 6 to to IN cord-281487-x0a9qgjs 12 7 date date NN cord-281487-x0a9qgjs 12 8 and and CC cord-281487-x0a9qgjs 12 9 our -PRON- PRP$ cord-281487-x0a9qgjs 12 10 experience experience NN cord-281487-x0a9qgjs 12 11 , , , cord-281487-x0a9qgjs 12 12 we -PRON- PRP cord-281487-x0a9qgjs 12 13 present present VBP cord-281487-x0a9qgjs 12 14 testing testing NN cord-281487-x0a9qgjs 12 15 , , , cord-281487-x0a9qgjs 12 16 management management NN cord-281487-x0a9qgjs 12 17 , , , cord-281487-x0a9qgjs 12 18 and and CC cord-281487-x0a9qgjs 12 19 prevention prevention NN cord-281487-x0a9qgjs 12 20 methods method NNS cord-281487-x0a9qgjs 12 21 for for IN cord-281487-x0a9qgjs 12 22 COVID-19 covid-19 NN cord-281487-x0a9qgjs 12 23 . . . cord-281487-x0a9qgjs 13 1 Comprehensive comprehensive JJ cord-281487-x0a9qgjs 13 2 diagnostic diagnostic JJ cord-281487-x0a9qgjs 13 3 tests test NNS cord-281487-x0a9qgjs 13 4 should should MD cord-281487-x0a9qgjs 13 5 be be VB cord-281487-x0a9qgjs 13 6 performed perform VBN cord-281487-x0a9qgjs 13 7 to to TO cord-281487-x0a9qgjs 13 8 determine determine VB cord-281487-x0a9qgjs 13 9 disease disease NN cord-281487-x0a9qgjs 13 10 severity severity NN cord-281487-x0a9qgjs 13 11 , , , cord-281487-x0a9qgjs 13 12 phase phase NN cord-281487-x0a9qgjs 13 13 of of IN cord-281487-x0a9qgjs 13 14 illness illness NN cord-281487-x0a9qgjs 13 15 , , , cord-281487-x0a9qgjs 13 16 and and CC cord-281487-x0a9qgjs 13 17 identify identify VB cord-281487-x0a9qgjs 13 18 other other JJ cord-281487-x0a9qgjs 13 19 comorbidities comorbiditie NNS cord-281487-x0a9qgjs 13 20 in in IN cord-281487-x0a9qgjs 13 21 transplant transplant NN cord-281487-x0a9qgjs 13 22 recipients recipient NNS cord-281487-x0a9qgjs 13 23 diagnosed diagnose VBN cord-281487-x0a9qgjs 13 24 with with IN cord-281487-x0a9qgjs 13 25 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 13 26 . . . cord-281487-x0a9qgjs 14 1 Outpatients outpatient NNS cord-281487-x0a9qgjs 14 2 should should MD cord-281487-x0a9qgjs 14 3 receive receive VB cord-281487-x0a9qgjs 14 4 education education NN cord-281487-x0a9qgjs 14 5 for for IN cord-281487-x0a9qgjs 14 6 preventative preventative JJ cord-281487-x0a9qgjs 14 7 measures measure NNS cord-281487-x0a9qgjs 14 8 and and CC cord-281487-x0a9qgjs 14 9 optimal optimal JJ cord-281487-x0a9qgjs 14 10 health health NN cord-281487-x0a9qgjs 14 11 care care NN cord-281487-x0a9qgjs 14 12 delivery delivery NN cord-281487-x0a9qgjs 14 13 minimizing minimize VBG cord-281487-x0a9qgjs 14 14 potential potential JJ cord-281487-x0a9qgjs 14 15 infectious infectious JJ cord-281487-x0a9qgjs 14 16 exposures exposure NNS cord-281487-x0a9qgjs 14 17 . . . cord-281487-x0a9qgjs 15 1 Multidisciplinary multidisciplinary JJ cord-281487-x0a9qgjs 15 2 interventions intervention NNS cord-281487-x0a9qgjs 15 3 should should MD cord-281487-x0a9qgjs 15 4 be be VB cord-281487-x0a9qgjs 15 5 provided provide VBN cord-281487-x0a9qgjs 15 6 to to IN cord-281487-x0a9qgjs 15 7 hospitalized hospitalize VBN cord-281487-x0a9qgjs 15 8 transplant transplant NN cord-281487-x0a9qgjs 15 9 recipients recipient NNS cord-281487-x0a9qgjs 15 10 for for IN cord-281487-x0a9qgjs 15 11 COVID-19 covid-19 NN cord-281487-x0a9qgjs 15 12 because because IN cord-281487-x0a9qgjs 15 13 of of IN cord-281487-x0a9qgjs 15 14 the the DT cord-281487-x0a9qgjs 15 15 complexity complexity NN cord-281487-x0a9qgjs 15 16 of of IN cord-281487-x0a9qgjs 15 17 caring care VBG cord-281487-x0a9qgjs 15 18 for for IN cord-281487-x0a9qgjs 15 19 transplant transplant NN cord-281487-x0a9qgjs 15 20 recipients recipient NNS cord-281487-x0a9qgjs 15 21 . . . cord-281487-x0a9qgjs 16 1 SUMMARY summary NN cord-281487-x0a9qgjs 16 2 : : : cord-281487-x0a9qgjs 17 1 Transplant transplant NN cord-281487-x0a9qgjs 17 2 recipients recipient NNS cord-281487-x0a9qgjs 17 3 should should MD cord-281487-x0a9qgjs 17 4 strictly strictly RB cord-281487-x0a9qgjs 17 5 adhere adhere VB cord-281487-x0a9qgjs 17 6 to to IN cord-281487-x0a9qgjs 17 7 infection infection NN cord-281487-x0a9qgjs 17 8 prevention prevention NN cord-281487-x0a9qgjs 17 9 measures measure NNS cord-281487-x0a9qgjs 17 10 . . . cord-281487-x0a9qgjs 18 1 Understanding understanding NN cord-281487-x0a9qgjs 18 2 of of IN cord-281487-x0a9qgjs 18 3 the the DT cord-281487-x0a9qgjs 18 4 transplant transplant NN cord-281487-x0a9qgjs 18 5 specific specific JJ cord-281487-x0a9qgjs 18 6 pathophysiology pathophysiology NN cord-281487-x0a9qgjs 18 7 and and CC cord-281487-x0a9qgjs 18 8 development development NN cord-281487-x0a9qgjs 18 9 of of IN cord-281487-x0a9qgjs 18 10 effective effective JJ cord-281487-x0a9qgjs 18 11 treatment treatment NN cord-281487-x0a9qgjs 18 12 strategies strategy NNS cord-281487-x0a9qgjs 18 13 for for IN cord-281487-x0a9qgjs 18 14 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 18 15 should should MD cord-281487-x0a9qgjs 18 16 be be VB cord-281487-x0a9qgjs 18 17 prioritized prioritize VBN cord-281487-x0a9qgjs 18 18 . . . cord-281487-x0a9qgjs 19 1 The the DT cord-281487-x0a9qgjs 19 2 coronavirus coronavirus NN cord-281487-x0a9qgjs 19 3 disease disease NN cord-281487-x0a9qgjs 19 4 2019 2019 CD cord-281487-x0a9qgjs 20 1 ( ( -LRB- cord-281487-x0a9qgjs 20 2 COVID- covid- NN cord-281487-x0a9qgjs 20 3 19 19 CD cord-281487-x0a9qgjs 20 4 ) ) -RRB- cord-281487-x0a9qgjs 20 5 pandemic pandemic NN cord-281487-x0a9qgjs 20 6 has have VBZ cord-281487-x0a9qgjs 20 7 led lead VBN cord-281487-x0a9qgjs 20 8 to to IN cord-281487-x0a9qgjs 20 9 unique unique JJ cord-281487-x0a9qgjs 20 10 challenges challenge NNS cord-281487-x0a9qgjs 20 11 in in IN cord-281487-x0a9qgjs 20 12 solid solid JJ cord-281487-x0a9qgjs 20 13 organ organ NN cord-281487-x0a9qgjs 20 14 transplantation transplantation NN cord-281487-x0a9qgjs 20 15 as as IN cord-281487-x0a9qgjs 20 16 centers center NNS cord-281487-x0a9qgjs 20 17 balance balance VBP cord-281487-x0a9qgjs 20 18 the the DT cord-281487-x0a9qgjs 20 19 risk risk NN cord-281487-x0a9qgjs 20 20 of of IN cord-281487-x0a9qgjs 20 21 caring care VBG cord-281487-x0a9qgjs 20 22 for for IN cord-281487-x0a9qgjs 20 23 immunosuppressed immunosuppressed JJ cord-281487-x0a9qgjs 20 24 patients patient NNS cord-281487-x0a9qgjs 20 25 with with IN cord-281487-x0a9qgjs 20 26 the the DT cord-281487-x0a9qgjs 20 27 best good JJS cord-281487-x0a9qgjs 20 28 timing timing NN cord-281487-x0a9qgjs 20 29 and and CC cord-281487-x0a9qgjs 20 30 urgency urgency NN cord-281487-x0a9qgjs 20 31 of of IN cord-281487-x0a9qgjs 20 32 transplantation transplantation NN cord-281487-x0a9qgjs 20 33 . . . cord-281487-x0a9qgjs 21 1 Insufficient insufficient JJ cord-281487-x0a9qgjs 21 2 knowledge knowledge NN cord-281487-x0a9qgjs 21 3 about about IN cord-281487-x0a9qgjs 21 4 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 21 5 and and CC cord-281487-x0a9qgjs 21 6 the the DT cord-281487-x0a9qgjs 21 7 potential potential JJ cord-281487-x0a9qgjs 21 8 risks risk NNS cord-281487-x0a9qgjs 21 9 of of IN cord-281487-x0a9qgjs 21 10 COVID-19 covid-19 CD cord-281487-x0a9qgjs 21 11 for for IN cord-281487-x0a9qgjs 21 12 transplant transplant NN cord-281487-x0a9qgjs 21 13 donors donor NNS cord-281487-x0a9qgjs 21 14 and and CC cord-281487-x0a9qgjs 21 15 recipients recipient NNS cord-281487-x0a9qgjs 21 16 are be VBP cord-281487-x0a9qgjs 21 17 limiting limit VBG cord-281487-x0a9qgjs 21 18 organ organ NN cord-281487-x0a9qgjs 21 19 transplantation transplantation NN cord-281487-x0a9qgjs 21 20 as as RB cord-281487-x0a9qgjs 21 21 well well RB cord-281487-x0a9qgjs 21 22 as as IN cord-281487-x0a9qgjs 21 23 research research NN cord-281487-x0a9qgjs 21 24 in in IN cord-281487-x0a9qgjs 21 25 transplantation transplantation NN cord-281487-x0a9qgjs 21 26 [ [ -LRB- cord-281487-x0a9qgjs 21 27 1 1 CD cord-281487-x0a9qgjs 21 28 ] ] -RRB- cord-281487-x0a9qgjs 21 29 [ [ -LRB- cord-281487-x0a9qgjs 21 30 2 2 CD cord-281487-x0a9qgjs 21 31 ] ] -RRB- cord-281487-x0a9qgjs 21 32 [ [ -LRB- cord-281487-x0a9qgjs 21 33 3 3 CD cord-281487-x0a9qgjs 21 34 ] ] -RRB- cord-281487-x0a9qgjs 21 35 . . . cord-281487-x0a9qgjs 22 1 However however RB cord-281487-x0a9qgjs 22 2 , , , cord-281487-x0a9qgjs 22 3 transplantation transplantation NN cord-281487-x0a9qgjs 22 4 is be VBZ cord-281487-x0a9qgjs 22 5 essential essential JJ cord-281487-x0a9qgjs 22 6 for for IN cord-281487-x0a9qgjs 22 7 lifesaving lifesave VBG cord-281487-x0a9qgjs 22 8 transplants transplant NNS cord-281487-x0a9qgjs 22 9 of of IN cord-281487-x0a9qgjs 22 10 heart heart NN cord-281487-x0a9qgjs 22 11 , , , cord-281487-x0a9qgjs 22 12 lung lung NN cord-281487-x0a9qgjs 22 13 , , , cord-281487-x0a9qgjs 22 14 or or CC cord-281487-x0a9qgjs 22 15 liver liver NN cord-281487-x0a9qgjs 22 16 and and CC cord-281487-x0a9qgjs 22 17 for for IN cord-281487-x0a9qgjs 22 18 deceased deceased JJ cord-281487-x0a9qgjs 22 19 donor donor NN cord-281487-x0a9qgjs 22 20 kidney kidney NN cord-281487-x0a9qgjs 22 21 transplantations transplantation NNS cord-281487-x0a9qgjs 22 22 ( ( -LRB- cord-281487-x0a9qgjs 22 23 KT KT NNP cord-281487-x0a9qgjs 22 24 ) ) -RRB- cord-281487-x0a9qgjs 22 25 in in IN cord-281487-x0a9qgjs 22 26 candidates candidate NNS cord-281487-x0a9qgjs 22 27 with with IN cord-281487-x0a9qgjs 22 28 a a DT cord-281487-x0a9qgjs 22 29 lack lack NN cord-281487-x0a9qgjs 22 30 of of IN cord-281487-x0a9qgjs 22 31 dialysis dialysis NN cord-281487-x0a9qgjs 22 32 access access NN cord-281487-x0a9qgjs 22 33 or or CC cord-281487-x0a9qgjs 22 34 who who WP cord-281487-x0a9qgjs 22 35 are be VBP cord-281487-x0a9qgjs 22 36 highly highly RB cord-281487-x0a9qgjs 22 37 sensitized sensitize VBN cord-281487-x0a9qgjs 22 38 [ [ -LRB- cord-281487-x0a9qgjs 22 39 4 4 CD cord-281487-x0a9qgjs 22 40 ] ] -RRB- cord-281487-x0a9qgjs 22 41 . . . cord-281487-x0a9qgjs 23 1 To to TO cord-281487-x0a9qgjs 23 2 assist assist VB cord-281487-x0a9qgjs 23 3 in in IN cord-281487-x0a9qgjs 23 4 the the DT cord-281487-x0a9qgjs 23 5 timing timing NN cord-281487-x0a9qgjs 23 6 of of IN cord-281487-x0a9qgjs 23 7 transplantation transplantation NN cord-281487-x0a9qgjs 23 8 during during IN cord-281487-x0a9qgjs 23 9 the the DT cord-281487-x0a9qgjs 23 10 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 23 11 pandemic pandemic NN cord-281487-x0a9qgjs 23 12 , , , cord-281487-x0a9qgjs 23 13 Massie Massie NNP cord-281487-x0a9qgjs 23 14 et et NNP cord-281487-x0a9qgjs 23 15 al al NNP cord-281487-x0a9qgjs 23 16 . . NNP cord-281487-x0a9qgjs 23 17 developed develop VBD cord-281487-x0a9qgjs 23 18 a a DT cord-281487-x0a9qgjs 23 19 model model NN cord-281487-x0a9qgjs 23 20 for for IN cord-281487-x0a9qgjs 23 21 mortality mortality NN cord-281487-x0a9qgjs 23 22 of of IN cord-281487-x0a9qgjs 23 23 wait wait NN cord-281487-x0a9qgjs 23 24 - - HYPH cord-281487-x0a9qgjs 23 25 listed list VBN cord-281487-x0a9qgjs 23 26 patients patient NNS cord-281487-x0a9qgjs 23 27 and and CC cord-281487-x0a9qgjs 23 28 transplant transplant NN cord-281487-x0a9qgjs 23 29 recipients recipient NNS cord-281487-x0a9qgjs 23 30 in in IN cord-281487-x0a9qgjs 23 31 relation relation NN cord-281487-x0a9qgjs 23 32 to to IN cord-281487-x0a9qgjs 23 33 COVID-19 covid-19 VB cord-281487-x0a9qgjs 23 34 [ [ -LRB- cord-281487-x0a9qgjs 23 35 5 5 CD cord-281487-x0a9qgjs 23 36 ] ] -RRB- cord-281487-x0a9qgjs 23 37 . . . cord-281487-x0a9qgjs 24 1 Kidney kidney NN cord-281487-x0a9qgjs 24 2 transplantation transplantation NN cord-281487-x0a9qgjs 24 3 ( ( -LRB- cord-281487-x0a9qgjs 24 4 KT KT NNP cord-281487-x0a9qgjs 24 5 ) ) -RRB- cord-281487-x0a9qgjs 24 6 reliably reliably RB cord-281487-x0a9qgjs 24 7 provides provide VBZ cord-281487-x0a9qgjs 24 8 survival survival NN cord-281487-x0a9qgjs 24 9 benefit benefit NN cord-281487-x0a9qgjs 24 10 unless unless IN cord-281487-x0a9qgjs 24 11 mortality mortality NN cord-281487-x0a9qgjs 24 12 risk risk NN cord-281487-x0a9qgjs 24 13 for for IN cord-281487-x0a9qgjs 24 14 KT KT NNP cord-281487-x0a9qgjs 24 15 recipients recipient NNS cord-281487-x0a9qgjs 24 16 exposed expose VBN cord-281487-x0a9qgjs 24 17 to to IN cord-281487-x0a9qgjs 24 18 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 24 19 is be VBZ cord-281487-x0a9qgjs 24 20 50 50 CD cord-281487-x0a9qgjs 24 21 % % NN cord-281487-x0a9qgjs 24 22 or or CC cord-281487-x0a9qgjs 24 23 higher high JJR cord-281487-x0a9qgjs 24 24 and and CC cord-281487-x0a9qgjs 24 25 community community NN cord-281487-x0a9qgjs 24 26 risk risk NN cord-281487-x0a9qgjs 24 27 of of IN cord-281487-x0a9qgjs 24 28 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 24 29 acquisition acquisition NN cord-281487-x0a9qgjs 24 30 is be VBZ cord-281487-x0a9qgjs 24 31 50 50 CD cord-281487-x0a9qgjs 24 32 % % NN cord-281487-x0a9qgjs 24 33 or or CC cord-281487-x0a9qgjs 24 34 more more JJR cord-281487-x0a9qgjs 24 35 per per IN cord-281487-x0a9qgjs 24 36 month month NN cord-281487-x0a9qgjs 24 37 over over IN cord-281487-x0a9qgjs 24 38 the the DT cord-281487-x0a9qgjs 24 39 first first JJ cord-281487-x0a9qgjs 24 40 6 6 CD cord-281487-x0a9qgjs 24 41 months month NNS cord-281487-x0a9qgjs 24 42 [ [ -LRB- cord-281487-x0a9qgjs 24 43 5 5 CD cord-281487-x0a9qgjs 24 44 ] ] -RRB- cord-281487-x0a9qgjs 24 45 . . . cord-281487-x0a9qgjs 25 1 To to IN cord-281487-x0a9qgjs 25 2 date date NN cord-281487-x0a9qgjs 25 3 , , , cord-281487-x0a9qgjs 25 4 the the DT cord-281487-x0a9qgjs 25 5 mortality mortality NN cord-281487-x0a9qgjs 25 6 of of IN cord-281487-x0a9qgjs 25 7 KT KT NNP cord-281487-x0a9qgjs 25 8 recipients recipient NNS cord-281487-x0a9qgjs 25 9 with with IN cord-281487-x0a9qgjs 25 10 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 25 11 is be VBZ cord-281487-x0a9qgjs 25 12 much much RB cord-281487-x0a9qgjs 25 13 less less JJR cord-281487-x0a9qgjs 25 14 than than IN cord-281487-x0a9qgjs 25 15 50 50 CD cord-281487-x0a9qgjs 25 16 % % NN cord-281487-x0a9qgjs 25 17 ( ( -LRB- cord-281487-x0a9qgjs 25 18 Table table NN cord-281487-x0a9qgjs 25 19 2 2 CD cord-281487-x0a9qgjs 25 20 ) ) -RRB- cord-281487-x0a9qgjs 25 21 . . . cord-281487-x0a9qgjs 26 1 However however RB cord-281487-x0a9qgjs 26 2 , , , cord-281487-x0a9qgjs 26 3 this this DT cord-281487-x0a9qgjs 26 4 model model NN cord-281487-x0a9qgjs 26 5 does do VBZ cord-281487-x0a9qgjs 26 6 not not RB cord-281487-x0a9qgjs 26 7 account account VB cord-281487-x0a9qgjs 26 8 for for IN cord-281487-x0a9qgjs 26 9 the the DT cord-281487-x0a9qgjs 26 10 risk risk NN cord-281487-x0a9qgjs 26 11 of of IN cord-281487-x0a9qgjs 26 12 living live VBG cord-281487-x0a9qgjs 26 13 kidney kidney NN cord-281487-x0a9qgjs 26 14 donors donor NNS cord-281487-x0a9qgjs 26 15 , , , cord-281487-x0a9qgjs 26 16 and and CC cord-281487-x0a9qgjs 26 17 this this DT cord-281487-x0a9qgjs 26 18 should should MD cord-281487-x0a9qgjs 26 19 be be VB cord-281487-x0a9qgjs 26 20 considered consider VBN cord-281487-x0a9qgjs 26 21 in in IN cord-281487-x0a9qgjs 26 22 transplant transplant NN cord-281487-x0a9qgjs 26 23 decision decision NN cord-281487-x0a9qgjs 26 24 - - HYPH cord-281487-x0a9qgjs 26 25 making making NN cord-281487-x0a9qgjs 26 26 . . . cord-281487-x0a9qgjs 27 1 Candidates candidate NNS cord-281487-x0a9qgjs 27 2 and and CC cord-281487-x0a9qgjs 27 3 families family NNS cord-281487-x0a9qgjs 27 4 should should MD cord-281487-x0a9qgjs 27 5 be be VB cord-281487-x0a9qgjs 27 6 educated educate VBN cord-281487-x0a9qgjs 27 7 about about IN cord-281487-x0a9qgjs 27 8 increased increase VBN cord-281487-x0a9qgjs 27 9 risks risk NNS cord-281487-x0a9qgjs 27 10 , , , cord-281487-x0a9qgjs 27 11 and and CC cord-281487-x0a9qgjs 27 12 transplant transplant NN cord-281487-x0a9qgjs 27 13 teams team NNS cord-281487-x0a9qgjs 27 14 should should MD cord-281487-x0a9qgjs 27 15 ensure ensure VB cord-281487-x0a9qgjs 27 16 that that IN cord-281487-x0a9qgjs 27 17 households household NNS cord-281487-x0a9qgjs 27 18 are be VBP cord-281487-x0a9qgjs 27 19 willing willing JJ cord-281487-x0a9qgjs 27 20 to to TO cord-281487-x0a9qgjs 27 21 adhere adhere VB cord-281487-x0a9qgjs 27 22 to to IN cord-281487-x0a9qgjs 27 23 the the DT cord-281487-x0a9qgjs 27 24 mitigation mitigation NN cord-281487-x0a9qgjs 27 25 precautions precaution NNS cord-281487-x0a9qgjs 27 26 that that WDT cord-281487-x0a9qgjs 27 27 may may MD cord-281487-x0a9qgjs 27 28 be be VB cord-281487-x0a9qgjs 27 29 more more RBR cord-281487-x0a9qgjs 27 30 stringent stringent JJ cord-281487-x0a9qgjs 27 31 than than IN cord-281487-x0a9qgjs 27 32 local local JJ cord-281487-x0a9qgjs 27 33 official official JJ cord-281487-x0a9qgjs 27 34 guidance guidance NN cord-281487-x0a9qgjs 27 35 . . . cord-281487-x0a9qgjs 28 1 Transplantation transplantation NN cord-281487-x0a9qgjs 28 2 centers center NNS cord-281487-x0a9qgjs 28 3 have have VBP cord-281487-x0a9qgjs 28 4 rapidly rapidly RB cord-281487-x0a9qgjs 28 5 adopted adopt VBN cord-281487-x0a9qgjs 28 6 management management NN cord-281487-x0a9qgjs 28 7 practices practice NNS cord-281487-x0a9qgjs 28 8 that that WDT cord-281487-x0a9qgjs 28 9 will will MD cord-281487-x0a9qgjs 28 10 continue continue VB cord-281487-x0a9qgjs 28 11 to to TO cord-281487-x0a9qgjs 28 12 evolve evolve VB cord-281487-x0a9qgjs 28 13 as as IN cord-281487-x0a9qgjs 28 14 knowledge knowledge NN cord-281487-x0a9qgjs 28 15 for for IN cord-281487-x0a9qgjs 28 16 severe severe JJ cord-281487-x0a9qgjs 28 17 acute acute JJ cord-281487-x0a9qgjs 28 18 respiratory respiratory JJ cord-281487-x0a9qgjs 28 19 syndrome syndrome NN cord-281487-x0a9qgjs 28 20 coronavirus coronavirus NN cord-281487-x0a9qgjs 28 21 2 2 CD cord-281487-x0a9qgjs 29 1 ( ( -LRB- cord-281487-x0a9qgjs 29 2 SARS SARS NNP cord-281487-x0a9qgjs 29 3 - - HYPH cord-281487-x0a9qgjs 29 4 CoV-2 CoV-2 NNP cord-281487-x0a9qgjs 29 5 ) ) -RRB- cord-281487-x0a9qgjs 29 6 expands expand VBZ cord-281487-x0a9qgjs 29 7 [ [ -LRB- cord-281487-x0a9qgjs 29 8 1 1 CD cord-281487-x0a9qgjs 29 9 , , , cord-281487-x0a9qgjs 29 10 2 2 CD cord-281487-x0a9qgjs 29 11 ] ] -RRB- cord-281487-x0a9qgjs 29 12 . . . cord-281487-x0a9qgjs 30 1 This this DT cord-281487-x0a9qgjs 30 2 review review NN cord-281487-x0a9qgjs 30 3 article article NN cord-281487-x0a9qgjs 30 4 will will MD cord-281487-x0a9qgjs 30 5 provide provide VB cord-281487-x0a9qgjs 30 6 an an DT cord-281487-x0a9qgjs 30 7 overview overview NN cord-281487-x0a9qgjs 30 8 of of IN cord-281487-x0a9qgjs 30 9 our -PRON- PRP$ cord-281487-x0a9qgjs 30 10 current current JJ cord-281487-x0a9qgjs 30 11 understanding understanding NN cord-281487-x0a9qgjs 30 12 of of IN cord-281487-x0a9qgjs 30 13 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 30 14 as as IN cord-281487-x0a9qgjs 30 15 a a DT cord-281487-x0a9qgjs 30 16 basis basis NN cord-281487-x0a9qgjs 30 17 for for IN cord-281487-x0a9qgjs 30 18 optimizing optimize VBG cord-281487-x0a9qgjs 30 19 the the DT cord-281487-x0a9qgjs 30 20 care care NN cord-281487-x0a9qgjs 30 21 of of IN cord-281487-x0a9qgjs 30 22 this this DT cord-281487-x0a9qgjs 30 23 vulnerable vulnerable JJ cord-281487-x0a9qgjs 30 24 population population NN cord-281487-x0a9qgjs 30 25 . . . cord-281487-x0a9qgjs 31 1 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 31 2 is be VBZ cord-281487-x0a9qgjs 31 3 an an DT cord-281487-x0a9qgjs 31 4 infectious infectious JJ cord-281487-x0a9qgjs 31 5 viral viral JJ cord-281487-x0a9qgjs 31 6 disease disease NN cord-281487-x0a9qgjs 31 7 caused cause VBN cord-281487-x0a9qgjs 31 8 by by IN cord-281487-x0a9qgjs 31 9 SARS SARS NNP cord-281487-x0a9qgjs 31 10 - - HYPH cord-281487-x0a9qgjs 31 11 CoV-2 CoV-2 NNP cord-281487-x0a9qgjs 31 12 [ [ -LRB- cord-281487-x0a9qgjs 31 13 6 6 CD cord-281487-x0a9qgjs 31 14 ] ] -RRB- cord-281487-x0a9qgjs 31 15 . . . cord-281487-x0a9qgjs 32 1 SARS SARS NNP cord-281487-x0a9qgjs 32 2 - - HYPH cord-281487-x0a9qgjs 32 3 CoV-2 CoV-2 NNP cord-281487-x0a9qgjs 32 4 spike spike NN cord-281487-x0a9qgjs 32 5 proteins protein NNS cord-281487-x0a9qgjs 32 6 bind bind VBP cord-281487-x0a9qgjs 32 7 to to IN cord-281487-x0a9qgjs 32 8 the the DT cord-281487-x0a9qgjs 32 9 angiotensinconverting angiotensinconverting NN cord-281487-x0a9qgjs 32 10 enzyme enzyme NN cord-281487-x0a9qgjs 32 11 2 2 CD cord-281487-x0a9qgjs 32 12 ( ( -LRB- cord-281487-x0a9qgjs 32 13 ACE2 ACE2 NNP cord-281487-x0a9qgjs 32 14 ) ) -RRB- cord-281487-x0a9qgjs 32 15 , , , cord-281487-x0a9qgjs 32 16 which which WDT cord-281487-x0a9qgjs 32 17 is be VBZ cord-281487-x0a9qgjs 32 18 located locate VBN cord-281487-x0a9qgjs 32 19 on on IN cord-281487-x0a9qgjs 32 20 the the DT cord-281487-x0a9qgjs 32 21 surface surface NN cord-281487-x0a9qgjs 32 22 of of IN cord-281487-x0a9qgjs 32 23 many many JJ cord-281487-x0a9qgjs 32 24 cell cell NN cord-281487-x0a9qgjs 32 25 types type NNS cord-281487-x0a9qgjs 32 26 including include VBG cord-281487-x0a9qgjs 32 27 heart heart NN cord-281487-x0a9qgjs 32 28 , , , cord-281487-x0a9qgjs 32 29 lung lung NN cord-281487-x0a9qgjs 32 30 , , , cord-281487-x0a9qgjs 32 31 kidney kidney NN cord-281487-x0a9qgjs 32 32 , , , cord-281487-x0a9qgjs 32 33 liver liver NN cord-281487-x0a9qgjs 32 34 , , , cord-281487-x0a9qgjs 32 35 gastrointestinal gastrointestinal JJ cord-281487-x0a9qgjs 32 36 tract tract NN cord-281487-x0a9qgjs 32 37 and and CC cord-281487-x0a9qgjs 32 38 triggers trigger VBZ cord-281487-x0a9qgjs 32 39 internalization internalization NN cord-281487-x0a9qgjs 32 40 of of IN cord-281487-x0a9qgjs 32 41 the the DT cord-281487-x0a9qgjs 32 42 virus virus NN cord-281487-x0a9qgjs 32 43 [ [ -LRB- cord-281487-x0a9qgjs 32 44 6 6 CD cord-281487-x0a9qgjs 32 45 ] ] -RRB- cord-281487-x0a9qgjs 32 46 . . . cord-281487-x0a9qgjs 33 1 The the DT cord-281487-x0a9qgjs 33 2 targeting targeting NN cord-281487-x0a9qgjs 33 3 of of IN cord-281487-x0a9qgjs 33 4 ACE2 ACE2 NNP cord-281487-x0a9qgjs 33 5 by by IN cord-281487-x0a9qgjs 33 6 SARS SARS NNP cord-281487-x0a9qgjs 33 7 - - HYPH cord-281487-x0a9qgjs 33 8 CoV-2 CoV-2 NNP cord-281487-x0a9qgjs 33 9 leads lead VBZ cord-281487-x0a9qgjs 33 10 to to IN cord-281487-x0a9qgjs 33 11 reduced reduce VBN cord-281487-x0a9qgjs 33 12 ACE2 ACE2 NNP cord-281487-x0a9qgjs 33 13 level level NN cord-281487-x0a9qgjs 33 14 and and CC cord-281487-x0a9qgjs 33 15 increased increase VBN cord-281487-x0a9qgjs 33 16 angiotensin angiotensin NN cord-281487-x0a9qgjs 33 17 II ii CD cord-281487-x0a9qgjs 33 18 levels level NNS cord-281487-x0a9qgjs 33 19 [ [ -LRB- cord-281487-x0a9qgjs 33 20 7 7 CD cord-281487-x0a9qgjs 33 21 ] ] -RRB- cord-281487-x0a9qgjs 33 22 . . . cord-281487-x0a9qgjs 34 1 Subsequently subsequently RB cord-281487-x0a9qgjs 34 2 , , , cord-281487-x0a9qgjs 34 3 this this DT cord-281487-x0a9qgjs 34 4 process process NN cord-281487-x0a9qgjs 34 5 can can MD cord-281487-x0a9qgjs 34 6 activate activate VB cord-281487-x0a9qgjs 34 7 the the DT cord-281487-x0a9qgjs 34 8 angiotensin angiotensin NN cord-281487-x0a9qgjs 34 9 II II NNP cord-281487-x0a9qgjs 34 10 pathway pathway NN cord-281487-x0a9qgjs 34 11 , , , cord-281487-x0a9qgjs 34 12 cause cause VB cord-281487-x0a9qgjs 34 13 dysregulation dysregulation NN cord-281487-x0a9qgjs 34 14 of of IN cord-281487-x0a9qgjs 34 15 complement complement NN cord-281487-x0a9qgjs 34 16 , , , cord-281487-x0a9qgjs 34 17 hypercoagulation hypercoagulation NN cord-281487-x0a9qgjs 34 18 , , , cord-281487-x0a9qgjs 34 19 hypoxia hypoxia NN cord-281487-x0a9qgjs 34 20 , , , cord-281487-x0a9qgjs 34 21 hypotension hypotension NN cord-281487-x0a9qgjs 34 22 , , , cord-281487-x0a9qgjs 34 23 and and CC cord-281487-x0a9qgjs 34 24 cytokine cytokine NN cord-281487-x0a9qgjs 34 25 storm storm NN cord-281487-x0a9qgjs 34 26 [ [ -LRB- cord-281487-x0a9qgjs 34 27 8 8 CD cord-281487-x0a9qgjs 34 28 ] ] -RRB- cord-281487-x0a9qgjs 34 29 . . . cord-281487-x0a9qgjs 35 1 In in IN cord-281487-x0a9qgjs 35 2 addition addition NN cord-281487-x0a9qgjs 35 3 to to IN cord-281487-x0a9qgjs 35 4 direct direct JJ cord-281487-x0a9qgjs 35 5 invasion invasion NN cord-281487-x0a9qgjs 35 6 by by IN cord-281487-x0a9qgjs 35 7 SARS SARS NNP cord-281487-x0a9qgjs 35 8 - - HYPH cord-281487-x0a9qgjs 35 9 CoV-2 CoV-2 NNP cord-281487-x0a9qgjs 35 10 , , , cord-281487-x0a9qgjs 35 11 these these DT cord-281487-x0a9qgjs 35 12 complex complex JJ cord-281487-x0a9qgjs 35 13 processes process NNS cord-281487-x0a9qgjs 35 14 can can MD cord-281487-x0a9qgjs 35 15 cause cause VB cord-281487-x0a9qgjs 35 16 to to IN cord-281487-x0a9qgjs 35 17 damage damage NN cord-281487-x0a9qgjs 35 18 to to IN cord-281487-x0a9qgjs 35 19 multiple multiple JJ cord-281487-x0a9qgjs 35 20 organs organ NNS cord-281487-x0a9qgjs 35 21 [ [ -LRB- cord-281487-x0a9qgjs 35 22 8 8 CD cord-281487-x0a9qgjs 35 23 ] ] -RRB- cord-281487-x0a9qgjs 35 24 . . . cord-281487-x0a9qgjs 36 1 In in IN cord-281487-x0a9qgjs 36 2 a a DT cord-281487-x0a9qgjs 36 3 prospective prospective JJ cord-281487-x0a9qgjs 36 4 study study NN cord-281487-x0a9qgjs 36 5 of of IN cord-281487-x0a9qgjs 36 6 20,133 20,133 CD cord-281487-x0a9qgjs 36 7 hospitalized hospitalize VBN cord-281487-x0a9qgjs 36 8 patients patient NNS cord-281487-x0a9qgjs 36 9 with with IN cord-281487-x0a9qgjs 36 10 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 36 11 , , , cord-281487-x0a9qgjs 36 12 old old JJ cord-281487-x0a9qgjs 36 13 age age NN cord-281487-x0a9qgjs 36 14 , , , cord-281487-x0a9qgjs 36 15 male male NN cord-281487-x0a9qgjs 36 16 , , , cord-281487-x0a9qgjs 36 17 obesity obesity NN cord-281487-x0a9qgjs 36 18 , , , cord-281487-x0a9qgjs 36 19 and and CC cord-281487-x0a9qgjs 36 20 comorbidities comorbiditie NNS cord-281487-x0a9qgjs 36 21 , , , cord-281487-x0a9qgjs 36 22 including include VBG cord-281487-x0a9qgjs 36 23 chronic chronic JJ cord-281487-x0a9qgjs 36 24 cardiac cardiac NN cord-281487-x0a9qgjs 36 25 , , , cord-281487-x0a9qgjs 36 26 pulmonary pulmonary JJ cord-281487-x0a9qgjs 36 27 , , , cord-281487-x0a9qgjs 36 28 kidney kidney NN cord-281487-x0a9qgjs 36 29 , , , cord-281487-x0a9qgjs 36 30 liver liver NN cord-281487-x0a9qgjs 36 31 disease disease NN cord-281487-x0a9qgjs 36 32 , , , cord-281487-x0a9qgjs 36 33 were be VBD cord-281487-x0a9qgjs 36 34 risk risk NN cord-281487-x0a9qgjs 36 35 factors factor NNS cord-281487-x0a9qgjs 36 36 of of IN cord-281487-x0a9qgjs 36 37 death death NN cord-281487-x0a9qgjs 36 38 [ [ -LRB- cord-281487-x0a9qgjs 36 39 9 9 CD cord-281487-x0a9qgjs 36 40 ] ] -RRB- cord-281487-x0a9qgjs 36 41 . . . cord-281487-x0a9qgjs 37 1 Transplant transplant NN cord-281487-x0a9qgjs 37 2 recipients recipient NNS cord-281487-x0a9qgjs 37 3 have have VBP cord-281487-x0a9qgjs 37 4 several several JJ cord-281487-x0a9qgjs 37 5 factors factor NNS cord-281487-x0a9qgjs 37 6 contributing contribute VBG cord-281487-x0a9qgjs 37 7 to to IN cord-281487-x0a9qgjs 37 8 the the DT cord-281487-x0a9qgjs 37 9 risk risk NN cord-281487-x0a9qgjs 37 10 of of IN cord-281487-x0a9qgjs 37 11 worse bad JJR cord-281487-x0a9qgjs 37 12 outcomes outcome NNS cord-281487-x0a9qgjs 37 13 , , , cord-281487-x0a9qgjs 37 14 including include VBG cord-281487-x0a9qgjs 37 15 advanced advanced JJ cord-281487-x0a9qgjs 37 16 age age NN cord-281487-x0a9qgjs 37 17 , , , cord-281487-x0a9qgjs 37 18 immunosuppression immunosuppression NN cord-281487-x0a9qgjs 37 19 , , , cord-281487-x0a9qgjs 37 20 defective defective JJ cord-281487-x0a9qgjs 37 21 mucocutaneous mucocutaneous JJ cord-281487-x0a9qgjs 37 22 barrier barrier NN cord-281487-x0a9qgjs 37 23 , , , cord-281487-x0a9qgjs 37 24 co co NN cord-281487-x0a9qgjs 37 25 - - NN cord-281487-x0a9qgjs 37 26 infection infection NN cord-281487-x0a9qgjs 37 27 , , , cord-281487-x0a9qgjs 37 28 drug drug NN cord-281487-x0a9qgjs 37 29 - - HYPH cord-281487-x0a9qgjs 37 30 induced induce VBN cord-281487-x0a9qgjs 37 31 leukopenia leukopenia NN cord-281487-x0a9qgjs 37 32 , , , cord-281487-x0a9qgjs 37 33 and and CC cord-281487-x0a9qgjs 37 34 underlying underlie VBG cord-281487-x0a9qgjs 37 35 cardiovascular cardiovascular JJ cord-281487-x0a9qgjs 37 36 comorbidities comorbiditie NNS cord-281487-x0a9qgjs 37 37 [ [ -LRB- cord-281487-x0a9qgjs 37 38 10 10 CD cord-281487-x0a9qgjs 37 39 ] ] -RRB- cord-281487-x0a9qgjs 37 40 . . . cord-281487-x0a9qgjs 38 1 The the DT cord-281487-x0a9qgjs 38 2 mortality mortality NN cord-281487-x0a9qgjs 38 3 rates rate NNS cord-281487-x0a9qgjs 38 4 of of IN cord-281487-x0a9qgjs 38 5 transplant transplant NN cord-281487-x0a9qgjs 38 6 recipients recipient NNS cord-281487-x0a9qgjs 38 7 with with IN cord-281487-x0a9qgjs 38 8 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 38 9 may may MD cord-281487-x0a9qgjs 38 10 be be VB cord-281487-x0a9qgjs 38 11 higher high JJR cord-281487-x0a9qgjs 38 12 than than IN cord-281487-x0a9qgjs 38 13 in in IN cord-281487-x0a9qgjs 38 14 the the DT cord-281487-x0a9qgjs 38 15 general general JJ cord-281487-x0a9qgjs 38 16 population population NN cord-281487-x0a9qgjs 38 17 . . . cord-281487-x0a9qgjs 39 1 Chaudhry Chaudhry NNP cord-281487-x0a9qgjs 39 2 et et NNP cord-281487-x0a9qgjs 39 3 al al NNP cord-281487-x0a9qgjs 39 4 . . . cord-281487-x0a9qgjs 40 1 compared compare VBN cord-281487-x0a9qgjs 40 2 the the DT cord-281487-x0a9qgjs 40 3 mortality mortality NN cord-281487-x0a9qgjs 40 4 between between IN cord-281487-x0a9qgjs 40 5 hospitalized hospitalize VBN cord-281487-x0a9qgjs 40 6 transplant transplant NN cord-281487-x0a9qgjs 40 7 recipients recipient NNS cord-281487-x0a9qgjs 40 8 and and CC cord-281487-x0a9qgjs 40 9 hospitalized hospitalize VBN cord-281487-x0a9qgjs 40 10 non non JJ cord-281487-x0a9qgjs 40 11 - - JJ cord-281487-x0a9qgjs 40 12 transplant transplant JJ cord-281487-x0a9qgjs 40 13 patients patient NNS cord-281487-x0a9qgjs 40 14 [ [ -LRB- cord-281487-x0a9qgjs 40 15 11 11 CD cord-281487-x0a9qgjs 40 16 ] ] -RRB- cord-281487-x0a9qgjs 40 17 . . . cord-281487-x0a9qgjs 41 1 They -PRON- PRP cord-281487-x0a9qgjs 41 2 showed show VBD cord-281487-x0a9qgjs 41 3 that that IN cord-281487-x0a9qgjs 41 4 transplant transplant NN cord-281487-x0a9qgjs 41 5 status status NN cord-281487-x0a9qgjs 41 6 itself -PRON- PRP cord-281487-x0a9qgjs 41 7 does do VBZ cord-281487-x0a9qgjs 41 8 not not RB cord-281487-x0a9qgjs 41 9 affect affect VB cord-281487-x0a9qgjs 41 10 the the DT cord-281487-x0a9qgjs 41 11 mortality mortality NN cord-281487-x0a9qgjs 41 12 in in IN cord-281487-x0a9qgjs 41 13 patients patient NNS cord-281487-x0a9qgjs 41 14 hospitalized hospitalize VBN cord-281487-x0a9qgjs 41 15 with with IN cord-281487-x0a9qgjs 41 16 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 41 17 ( ( -LRB- cord-281487-x0a9qgjs 41 18 22.8 22.8 CD cord-281487-x0a9qgjs 41 19 % % NN cord-281487-x0a9qgjs 41 20 in in IN cord-281487-x0a9qgjs 41 21 transplant transplant NN cord-281487-x0a9qgjs 41 22 recipients recipient NNS cord-281487-x0a9qgjs 41 23 vs. vs. IN cord-281487-x0a9qgjs 41 24 25 25 CD cord-281487-x0a9qgjs 41 25 % % NN cord-281487-x0a9qgjs 41 26 in in IN cord-281487-x0a9qgjs 41 27 non non JJ cord-281487-x0a9qgjs 41 28 - - JJ cord-281487-x0a9qgjs 41 29 transplant transplant JJ cord-281487-x0a9qgjs 41 30 patients patient NNS cord-281487-x0a9qgjs 41 31 ) ) -RRB- cord-281487-x0a9qgjs 42 1 [ [ -LRB- cord-281487-x0a9qgjs 42 2 11 11 CD cord-281487-x0a9qgjs 42 3 ] ] -RRB- cord-281487-x0a9qgjs 42 4 . . . cord-281487-x0a9qgjs 43 1 However however RB cord-281487-x0a9qgjs 43 2 , , , cord-281487-x0a9qgjs 43 3 the the DT cord-281487-x0a9qgjs 43 4 proportion proportion NN cord-281487-x0a9qgjs 43 5 of of IN cord-281487-x0a9qgjs 43 6 severe severe JJ cord-281487-x0a9qgjs 43 7 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 43 8 severity severity NN cord-281487-x0a9qgjs 43 9 scores score NNS cord-281487-x0a9qgjs 43 10 associated associate VBN cord-281487-x0a9qgjs 43 11 with with IN cord-281487-x0a9qgjs 43 12 mortality mortality NN cord-281487-x0a9qgjs 43 13 was be VBD cord-281487-x0a9qgjs 43 14 8.6 8.6 CD cord-281487-x0a9qgjs 43 15 % % NN cord-281487-x0a9qgjs 43 16 and and CC cord-281487-x0a9qgjs 43 17 19 19 CD cord-281487-x0a9qgjs 43 18 % % NN cord-281487-x0a9qgjs 43 19 in in IN cord-281487-x0a9qgjs 43 20 transplant transplant NN cord-281487-x0a9qgjs 43 21 recipients recipient NNS cord-281487-x0a9qgjs 43 22 and and CC cord-281487-x0a9qgjs 43 23 non non JJ cord-281487-x0a9qgjs 43 24 - - JJ cord-281487-x0a9qgjs 43 25 transplant transplant JJ cord-281487-x0a9qgjs 43 26 patients patient NNS cord-281487-x0a9qgjs 43 27 [ [ -LRB- cord-281487-x0a9qgjs 43 28 11 11 CD cord-281487-x0a9qgjs 43 29 ] ] -RRB- cord-281487-x0a9qgjs 43 30 . . . cord-281487-x0a9qgjs 44 1 Roberts Roberts NNP cord-281487-x0a9qgjs 44 2 et et NNP cord-281487-x0a9qgjs 44 3 al al NNP cord-281487-x0a9qgjs 44 4 . . NNP cord-281487-x0a9qgjs 44 5 reported report VBD cord-281487-x0a9qgjs 44 6 that that IN cord-281487-x0a9qgjs 44 7 the the DT cord-281487-x0a9qgjs 44 8 mortality mortality NN cord-281487-x0a9qgjs 44 9 rate rate NN cord-281487-x0a9qgjs 44 10 was be VBD cord-281487-x0a9qgjs 44 11 higher high JJR cord-281487-x0a9qgjs 44 12 in in IN cord-281487-x0a9qgjs 44 13 transplant transplant NN cord-281487-x0a9qgjs 44 14 recipients recipient NNS cord-281487-x0a9qgjs 44 15 when when WRB cord-281487-x0a9qgjs 44 16 compared compare VBN cord-281487-x0a9qgjs 44 17 using use VBG cord-281487-x0a9qgjs 44 18 unpublished unpublished JJ cord-281487-x0a9qgjs 44 19 data datum NNS cord-281487-x0a9qgjs 44 20 from from IN cord-281487-x0a9qgjs 44 21 non non JJ cord-281487-x0a9qgjs 44 22 - - JJ cord-281487-x0a9qgjs 44 23 transplant transplant JJ cord-281487-x0a9qgjs 44 24 patients patient NNS cord-281487-x0a9qgjs 44 25 ( ( -LRB- cord-281487-x0a9qgjs 44 26 16 16 CD cord-281487-x0a9qgjs 44 27 % % NN cord-281487-x0a9qgjs 44 28 in in IN cord-281487-x0a9qgjs 44 29 transplant transplant NN cord-281487-x0a9qgjs 44 30 recipients recipient NNS cord-281487-x0a9qgjs 44 31 vs. vs. IN cord-281487-x0a9qgjs 44 32 4.3 4.3 CD cord-281487-x0a9qgjs 44 33 % % NN cord-281487-x0a9qgjs 44 34 in in IN cord-281487-x0a9qgjs 44 35 non non JJ cord-281487-x0a9qgjs 44 36 - - JJ cord-281487-x0a9qgjs 44 37 transplant transplant JJ cord-281487-x0a9qgjs 44 38 patients patient NNS cord-281487-x0a9qgjs 44 39 ) ) -RRB- cord-281487-x0a9qgjs 44 40 [ [ -LRB- cord-281487-x0a9qgjs 44 41 12 12 CD cord-281487-x0a9qgjs 44 42 ] ] -RRB- cord-281487-x0a9qgjs 44 43 . . . cord-281487-x0a9qgjs 45 1 In in IN cord-281487-x0a9qgjs 45 2 another another DT cord-281487-x0a9qgjs 45 3 study study NN cord-281487-x0a9qgjs 45 4 , , , cord-281487-x0a9qgjs 45 5 the the DT cord-281487-x0a9qgjs 45 6 mortality mortality NN cord-281487-x0a9qgjs 45 7 rate rate NN cord-281487-x0a9qgjs 45 8 was be VBD cord-281487-x0a9qgjs 45 9 20.5 20.5 CD cord-281487-x0a9qgjs 45 10 % % NN cord-281487-x0a9qgjs 45 11 among among IN cord-281487-x0a9qgjs 45 12 376 376 CD cord-281487-x0a9qgjs 45 13 hospitalized hospitalize VBN cord-281487-x0a9qgjs 45 14 transplant transplant NN cord-281487-x0a9qgjs 45 15 recipients recipient NNS cord-281487-x0a9qgjs 45 16 [ [ -LRB- cord-281487-x0a9qgjs 45 17 13 13 CD cord-281487-x0a9qgjs 45 18 ] ] -RRB- cord-281487-x0a9qgjs 45 19 . . . cord-281487-x0a9qgjs 46 1 Meanwhile meanwhile RB cord-281487-x0a9qgjs 46 2 , , , cord-281487-x0a9qgjs 46 3 in in IN cord-281487-x0a9qgjs 46 4 a a DT cord-281487-x0a9qgjs 46 5 study study NN cord-281487-x0a9qgjs 46 6 by by IN cord-281487-x0a9qgjs 46 7 Guan Guan NNP cord-281487-x0a9qgjs 46 8 et et FW cord-281487-x0a9qgjs 46 9 al al NNP cord-281487-x0a9qgjs 46 10 . . . cord-281487-x0a9qgjs 47 1 , , , cord-281487-x0a9qgjs 47 2 the the DT cord-281487-x0a9qgjs 47 3 mortality mortality NN cord-281487-x0a9qgjs 47 4 rate rate NN cord-281487-x0a9qgjs 47 5 was be VBD cord-281487-x0a9qgjs 47 6 1.4 1.4 CD cord-281487-x0a9qgjs 47 7 % % NN cord-281487-x0a9qgjs 47 8 in in IN cord-281487-x0a9qgjs 47 9 1099 1099 CD cord-281487-x0a9qgjs 47 10 hospitalized hospitalize VBN cord-281487-x0a9qgjs 47 11 nontransplant nontransplant JJ cord-281487-x0a9qgjs 47 12 patients patient NNS cord-281487-x0a9qgjs 48 1 [ [ -LRB- cord-281487-x0a9qgjs 48 2 14 14 CD cord-281487-x0a9qgjs 48 3 ] ] -RRB- cord-281487-x0a9qgjs 48 4 . . . cord-281487-x0a9qgjs 49 1 However however RB cord-281487-x0a9qgjs 49 2 , , , cord-281487-x0a9qgjs 49 3 it -PRON- PRP cord-281487-x0a9qgjs 49 4 is be VBZ cord-281487-x0a9qgjs 49 5 not not RB cord-281487-x0a9qgjs 49 6 yet yet RB cord-281487-x0a9qgjs 49 7 clear clear JJ cord-281487-x0a9qgjs 49 8 whether whether IN cord-281487-x0a9qgjs 49 9 transplantation transplantation NN cord-281487-x0a9qgjs 49 10 affects affect VBZ cord-281487-x0a9qgjs 49 11 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 49 12 associated associate VBN cord-281487-x0a9qgjs 49 13 mortality mortality NN cord-281487-x0a9qgjs 49 14 . . . cord-281487-x0a9qgjs 50 1 In in IN cord-281487-x0a9qgjs 50 2 the the DT cord-281487-x0a9qgjs 50 3 future future NN cord-281487-x0a9qgjs 50 4 , , , cord-281487-x0a9qgjs 50 5 more more JJR cord-281487-x0a9qgjs 50 6 results result NNS cord-281487-x0a9qgjs 50 7 need need VBP cord-281487-x0a9qgjs 50 8 to to TO cord-281487-x0a9qgjs 50 9 be be VB cord-281487-x0a9qgjs 50 10 accumulated accumulate VBN cord-281487-x0a9qgjs 50 11 . . . cord-281487-x0a9qgjs 51 1 The the DT cord-281487-x0a9qgjs 51 2 common common JJ cord-281487-x0a9qgjs 51 3 symptoms symptom NNS cord-281487-x0a9qgjs 51 4 in in IN cord-281487-x0a9qgjs 51 5 transplant transplant NN cord-281487-x0a9qgjs 51 6 recipients recipient NNS cord-281487-x0a9qgjs 51 7 are be VBP cord-281487-x0a9qgjs 51 8 outlined outline VBN cord-281487-x0a9qgjs 51 9 in in IN cord-281487-x0a9qgjs 51 10 Table Table NNP cord-281487-x0a9qgjs 51 11 1 1 CD cord-281487-x0a9qgjs 51 12 . . . cord-281487-x0a9qgjs 52 1 Atypical atypical JJ cord-281487-x0a9qgjs 52 2 symptoms symptom NNS cord-281487-x0a9qgjs 52 3 such such JJ cord-281487-x0a9qgjs 52 4 as as IN cord-281487-x0a9qgjs 52 5 diarrhea diarrhea NN cord-281487-x0a9qgjs 52 6 are be VBP cord-281487-x0a9qgjs 52 7 much much RB cord-281487-x0a9qgjs 52 8 more more RBR cord-281487-x0a9qgjs 52 9 common common JJ cord-281487-x0a9qgjs 52 10 ( ( -LRB- cord-281487-x0a9qgjs 52 11 22−67 22−67 CD cord-281487-x0a9qgjs 52 12 % % NN cord-281487-x0a9qgjs 52 13 ) ) -RRB- cord-281487-x0a9qgjs 52 14 compared compare VBN cord-281487-x0a9qgjs 52 15 to to IN cord-281487-x0a9qgjs 52 16 the the DT cord-281487-x0a9qgjs 52 17 general general JJ cord-281487-x0a9qgjs 52 18 population population NN cord-281487-x0a9qgjs 52 19 ( ( -LRB- cord-281487-x0a9qgjs 52 20 2−14 2−14 CD cord-281487-x0a9qgjs 52 21 % % NN cord-281487-x0a9qgjs 52 22 ) ) -RRB- cord-281487-x0a9qgjs 52 23 . . . cord-281487-x0a9qgjs 53 1 Fever Fever NNP cord-281487-x0a9qgjs 53 2 may may MD cord-281487-x0a9qgjs 53 3 be be VB cord-281487-x0a9qgjs 53 4 absent absent JJ cord-281487-x0a9qgjs 53 5 in in IN cord-281487-x0a9qgjs 53 6 up up IN cord-281487-x0a9qgjs 53 7 to to TO cord-281487-x0a9qgjs 53 8 50 50 CD cord-281487-x0a9qgjs 53 9 % % NN cord-281487-x0a9qgjs 53 10 of of IN cord-281487-x0a9qgjs 53 11 transplant transplant NN cord-281487-x0a9qgjs 53 12 recipients recipient NNS cord-281487-x0a9qgjs 53 13 [ [ -LRB- cord-281487-x0a9qgjs 53 14 10 10 CD cord-281487-x0a9qgjs 53 15 , , , cord-281487-x0a9qgjs 53 16 15 15 CD cord-281487-x0a9qgjs 53 17 , , , cord-281487-x0a9qgjs 53 18 16 16 CD cord-281487-x0a9qgjs 53 19 ] ] -RRB- cord-281487-x0a9qgjs 53 20 . . . cord-281487-x0a9qgjs 54 1 These these DT cord-281487-x0a9qgjs 54 2 atypical atypical JJ cord-281487-x0a9qgjs 54 3 symptoms symptom NNS cord-281487-x0a9qgjs 54 4 alongside alongside IN cord-281487-x0a9qgjs 54 5 baseline baseline JJ cord-281487-x0a9qgjs 54 6 cough cough NN cord-281487-x0a9qgjs 54 7 , , , cord-281487-x0a9qgjs 54 8 dyspnea dyspnea NN cord-281487-x0a9qgjs 54 9 , , , cord-281487-x0a9qgjs 54 10 or or CC cord-281487-x0a9qgjs 54 11 medication medication NN cord-281487-x0a9qgjs 54 12 side side NN cord-281487-x0a9qgjs 54 13 effects effect NNS cord-281487-x0a9qgjs 54 14 may may MD cord-281487-x0a9qgjs 54 15 make make VB cord-281487-x0a9qgjs 54 16 it -PRON- PRP cord-281487-x0a9qgjs 54 17 more more RBR cord-281487-x0a9qgjs 54 18 difficult difficult JJ cord-281487-x0a9qgjs 54 19 to to TO cord-281487-x0a9qgjs 54 20 identify identify VB cord-281487-x0a9qgjs 54 21 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 54 22 specific specific JJ cord-281487-x0a9qgjs 54 23 symptoms symptom NNS cord-281487-x0a9qgjs 54 24 in in IN cord-281487-x0a9qgjs 54 25 transplant transplant NN cord-281487-x0a9qgjs 54 26 recipients recipient NNS cord-281487-x0a9qgjs 54 27 . . . cord-281487-x0a9qgjs 55 1 Due due IN cord-281487-x0a9qgjs 55 2 to to IN cord-281487-x0a9qgjs 55 3 high high JJ cord-281487-x0a9qgjs 55 4 infectivity infectivity NN cord-281487-x0a9qgjs 55 5 , , , cord-281487-x0a9qgjs 55 6 transplant transplant NN cord-281487-x0a9qgjs 55 7 recipients recipient NNS cord-281487-x0a9qgjs 55 8 may may MD cord-281487-x0a9qgjs 55 9 present present VB cord-281487-x0a9qgjs 55 10 with with IN cord-281487-x0a9qgjs 55 11 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 55 12 at at IN cord-281487-x0a9qgjs 55 13 any any DT cord-281487-x0a9qgjs 55 14 time time NN cord-281487-x0a9qgjs 55 15 after after IN cord-281487-x0a9qgjs 55 16 transplant transplant NN cord-281487-x0a9qgjs 55 17 ( ( -LRB- cord-281487-x0a9qgjs 55 18 Table Table NNP cord-281487-x0a9qgjs 55 19 1 1 CD cord-281487-x0a9qgjs 55 20 ) ) -RRB- cord-281487-x0a9qgjs 55 21 . . . cord-281487-x0a9qgjs 56 1 Thus thus RB cord-281487-x0a9qgjs 56 2 , , , cord-281487-x0a9qgjs 56 3 a a DT cord-281487-x0a9qgjs 56 4 very very RB cord-281487-x0a9qgjs 56 5 low low JJ cord-281487-x0a9qgjs 56 6 threshold threshold NN cord-281487-x0a9qgjs 56 7 for for IN cord-281487-x0a9qgjs 56 8 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 56 9 testing testing NN cord-281487-x0a9qgjs 56 10 should should MD cord-281487-x0a9qgjs 56 11 be be VB cord-281487-x0a9qgjs 56 12 considered consider VBN cord-281487-x0a9qgjs 56 13 in in IN cord-281487-x0a9qgjs 56 14 recipients recipient NNS cord-281487-x0a9qgjs 56 15 with with IN cord-281487-x0a9qgjs 56 16 even even RB cord-281487-x0a9qgjs 56 17 minor minor JJ cord-281487-x0a9qgjs 56 18 symptoms symptom NNS cord-281487-x0a9qgjs 56 19 or or CC cord-281487-x0a9qgjs 56 20 high high JJ cord-281487-x0a9qgjs 56 21 - - HYPH cord-281487-x0a9qgjs 56 22 risk risk NN cord-281487-x0a9qgjs 56 23 exposures exposure NNS cord-281487-x0a9qgjs 56 24 . . . cord-281487-x0a9qgjs 57 1 Transplant transplant NN cord-281487-x0a9qgjs 57 2 recipients recipient NNS cord-281487-x0a9qgjs 57 3 diagnosed diagnose VBN cord-281487-x0a9qgjs 57 4 with with IN cord-281487-x0a9qgjs 57 5 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 57 6 should should MD cord-281487-x0a9qgjs 57 7 be be VB cord-281487-x0a9qgjs 57 8 considered consider VBN cord-281487-x0a9qgjs 57 9 for for IN cord-281487-x0a9qgjs 57 10 diagnostic diagnostic JJ cord-281487-x0a9qgjs 57 11 tests test NNS cord-281487-x0a9qgjs 57 12 to to TO cord-281487-x0a9qgjs 57 13 determine determine VB cord-281487-x0a9qgjs 57 14 disease disease NN cord-281487-x0a9qgjs 57 15 severity severity NN cord-281487-x0a9qgjs 57 16 , , , cord-281487-x0a9qgjs 57 17 phase phase NN cord-281487-x0a9qgjs 57 18 of of IN cord-281487-x0a9qgjs 57 19 illness illness NN cord-281487-x0a9qgjs 57 20 , , , cord-281487-x0a9qgjs 57 21 and and CC cord-281487-x0a9qgjs 57 22 identify identify VB cord-281487-x0a9qgjs 57 23 other other JJ cord-281487-x0a9qgjs 57 24 comorbidities comorbiditie NNS cord-281487-x0a9qgjs 57 25 . . . cord-281487-x0a9qgjs 58 1 Table table NN cord-281487-x0a9qgjs 58 2 3 3 CD cord-281487-x0a9qgjs 58 3 shows show VBZ cord-281487-x0a9qgjs 58 4 the the DT cord-281487-x0a9qgjs 58 5 current current JJ cord-281487-x0a9qgjs 58 6 tests test NNS cord-281487-x0a9qgjs 58 7 recommended recommend VBD cord-281487-x0a9qgjs 58 8 for for IN cord-281487-x0a9qgjs 58 9 transplant transplant NN cord-281487-x0a9qgjs 58 10 recipients recipient NNS cord-281487-x0a9qgjs 58 11 with with IN cord-281487-x0a9qgjs 58 12 COVID-19 covid-19 CD cord-281487-x0a9qgjs 58 13 at at IN cord-281487-x0a9qgjs 58 14 the the DT cord-281487-x0a9qgjs 58 15 Johns Johns NNP cord-281487-x0a9qgjs 58 16 Hopkins Hopkins NNP cord-281487-x0a9qgjs 58 17 Comprehensive Comprehensive NNP cord-281487-x0a9qgjs 58 18 Transplant Transplant NNP cord-281487-x0a9qgjs 58 19 Center Center NNP cord-281487-x0a9qgjs 58 20 ( ( -LRB- cord-281487-x0a9qgjs 58 21 JH JH NNP cord-281487-x0a9qgjs 58 22 - - HYPH cord-281487-x0a9qgjs 58 23 CTC CTC NNP cord-281487-x0a9qgjs 58 24 ) ) -RRB- cord-281487-x0a9qgjs 58 25 . . . cord-281487-x0a9qgjs 59 1 Lymphopenia Lymphopenia NNP cord-281487-x0a9qgjs 59 2 is be VBZ cord-281487-x0a9qgjs 59 3 a a DT cord-281487-x0a9qgjs 59 4 common common JJ cord-281487-x0a9qgjs 59 5 finding finding NN cord-281487-x0a9qgjs 59 6 that that WDT cord-281487-x0a9qgjs 59 7 correlates correlate VBZ cord-281487-x0a9qgjs 59 8 with with IN cord-281487-x0a9qgjs 59 9 disease disease NN cord-281487-x0a9qgjs 59 10 severity severity NN cord-281487-x0a9qgjs 59 11 ( ( -LRB- cord-281487-x0a9qgjs 59 12 Tables table NNS cord-281487-x0a9qgjs 59 13 2 2 CD cord-281487-x0a9qgjs 59 14 and and CC cord-281487-x0a9qgjs 59 15 3 3 CD cord-281487-x0a9qgjs 59 16 ) ) -RRB- cord-281487-x0a9qgjs 59 17 . . . cord-281487-x0a9qgjs 60 1 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 60 2 associated associated JJ cord-281487-x0a9qgjs 60 3 lymphopenia lymphopenia NNP cord-281487-x0a9qgjs 60 4 may may MD cord-281487-x0a9qgjs 60 5 be be VB cord-281487-x0a9qgjs 60 6 caused cause VBN cord-281487-x0a9qgjs 60 7 by by IN cord-281487-x0a9qgjs 60 8 direct direct JJ cord-281487-x0a9qgjs 60 9 virus virus NN cord-281487-x0a9qgjs 60 10 - - HYPH cord-281487-x0a9qgjs 60 11 induced induce VBN cord-281487-x0a9qgjs 60 12 cell cell NN cord-281487-x0a9qgjs 60 13 death death NN cord-281487-x0a9qgjs 60 14 or or CC cord-281487-x0a9qgjs 60 15 cytokine cytokine NN cord-281487-x0a9qgjs 60 16 storm storm NN cord-281487-x0a9qgjs 60 17 [ [ -LRB- cord-281487-x0a9qgjs 60 18 8 8 CD cord-281487-x0a9qgjs 60 19 , , , cord-281487-x0a9qgjs 60 20 26 26 CD cord-281487-x0a9qgjs 60 21 ] ] -RRB- cord-281487-x0a9qgjs 60 22 , , , cord-281487-x0a9qgjs 60 23 and and CC cord-281487-x0a9qgjs 60 24 further further RB cord-281487-x0a9qgjs 60 25 augmented augment VBN cord-281487-x0a9qgjs 60 26 by by IN cord-281487-x0a9qgjs 60 27 drug drug NN cord-281487-x0a9qgjs 60 28 - - HYPH cord-281487-x0a9qgjs 60 29 associated associate VBN cord-281487-x0a9qgjs 60 30 myelotoxicity myelotoxicity NN cord-281487-x0a9qgjs 60 31 in in IN cord-281487-x0a9qgjs 60 32 transplant transplant NN cord-281487-x0a9qgjs 60 33 recipients recipient NNS cord-281487-x0a9qgjs 60 34 receiving receive VBG cord-281487-x0a9qgjs 60 35 lymphocyte lymphocyte NN cord-281487-x0a9qgjs 60 36 - - HYPH cord-281487-x0a9qgjs 60 37 depleting deplete VBG cord-281487-x0a9qgjs 60 38 agents agent NNS cord-281487-x0a9qgjs 60 39 and/or and/or CC cord-281487-x0a9qgjs 60 40 antimetabolites antimetabolite NNS cord-281487-x0a9qgjs 60 41 . . . cord-281487-x0a9qgjs 61 1 Levels level NNS cord-281487-x0a9qgjs 61 2 of of IN cord-281487-x0a9qgjs 61 3 C c NN cord-281487-x0a9qgjs 61 4 - - HYPH cord-281487-x0a9qgjs 61 5 reactive reactive JJ cord-281487-x0a9qgjs 61 6 protein protein NN cord-281487-x0a9qgjs 61 7 ( ( -LRB- cord-281487-x0a9qgjs 61 8 CRP CRP NNP cord-281487-x0a9qgjs 61 9 ) ) -RRB- cord-281487-x0a9qgjs 61 10 and and CC cord-281487-x0a9qgjs 61 11 IL-6 IL-6 NNP cord-281487-x0a9qgjs 61 12 may may MD cord-281487-x0a9qgjs 61 13 be be VB cord-281487-x0a9qgjs 61 14 higher high JJR cord-281487-x0a9qgjs 61 15 in in IN cord-281487-x0a9qgjs 61 16 transplant transplant NN cord-281487-x0a9qgjs 61 17 recipients recipient NNS cord-281487-x0a9qgjs 61 18 with with IN cord-281487-x0a9qgjs 61 19 COVID-19 covid-19 CD cord-281487-x0a9qgjs 61 20 than than IN cord-281487-x0a9qgjs 61 21 the the DT cord-281487-x0a9qgjs 61 22 general general JJ cord-281487-x0a9qgjs 61 23 population population NN cord-281487-x0a9qgjs 61 24 ( ( -LRB- cord-281487-x0a9qgjs 61 25 Table Table NNP cord-281487-x0a9qgjs 61 26 2 2 CD cord-281487-x0a9qgjs 61 27 ) ) -RRB- cord-281487-x0a9qgjs 62 1 [ [ -LRB- cord-281487-x0a9qgjs 62 2 17 17 CD cord-281487-x0a9qgjs 62 3 - - SYM cord-281487-x0a9qgjs 62 4 19 19 CD cord-281487-x0a9qgjs 62 5 , , , cord-281487-x0a9qgjs 62 6 21 21 CD cord-281487-x0a9qgjs 62 7 , , , cord-281487-x0a9qgjs 62 8 24 24 CD cord-281487-x0a9qgjs 62 9 , , , cord-281487-x0a9qgjs 62 10 25 25 CD cord-281487-x0a9qgjs 62 11 ] ] -RRB- cord-281487-x0a9qgjs 62 12 . . . cord-281487-x0a9qgjs 63 1 Considering consider VBG cord-281487-x0a9qgjs 63 2 that that DT cord-281487-x0a9qgjs 63 3 lymphopenia lymphopenia NNP cord-281487-x0a9qgjs 63 4 , , , cord-281487-x0a9qgjs 63 5 CRP CRP NNP cord-281487-x0a9qgjs 63 6 , , , cord-281487-x0a9qgjs 63 7 and and CC cord-281487-x0a9qgjs 63 8 IL-6 IL-6 NNP cord-281487-x0a9qgjs 63 9 are be VBP cord-281487-x0a9qgjs 63 10 independent independent JJ cord-281487-x0a9qgjs 63 11 factors factor NNS cord-281487-x0a9qgjs 63 12 related relate VBN cord-281487-x0a9qgjs 63 13 to to IN cord-281487-x0a9qgjs 63 14 the the DT cord-281487-x0a9qgjs 63 15 severity severity NN cord-281487-x0a9qgjs 63 16 of of IN cord-281487-x0a9qgjs 63 17 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 63 18 [ [ -LRB- cord-281487-x0a9qgjs 63 19 27 27 CD cord-281487-x0a9qgjs 63 20 , , , cord-281487-x0a9qgjs 63 21 28 28 CD cord-281487-x0a9qgjs 63 22 ] ] -RRB- cord-281487-x0a9qgjs 63 23 , , , cord-281487-x0a9qgjs 63 24 these these DT cord-281487-x0a9qgjs 63 25 should should MD cord-281487-x0a9qgjs 63 26 be be VB cord-281487-x0a9qgjs 63 27 monitored monitor VBN cord-281487-x0a9qgjs 63 28 closely closely RB cord-281487-x0a9qgjs 63 29 in in IN cord-281487-x0a9qgjs 63 30 transplant transplant NN cord-281487-x0a9qgjs 63 31 recipients recipient NNS cord-281487-x0a9qgjs 63 32 hospitalized hospitalize VBN cord-281487-x0a9qgjs 63 33 with with IN cord-281487-x0a9qgjs 63 34 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 63 35 . . . cord-281487-x0a9qgjs 64 1 The the DT cord-281487-x0a9qgjs 64 2 incidence incidence NN cord-281487-x0a9qgjs 64 3 of of IN cord-281487-x0a9qgjs 64 4 liver liver NN cord-281487-x0a9qgjs 64 5 dysfunction dysfunction NN cord-281487-x0a9qgjs 64 6 ranges range VBZ cord-281487-x0a9qgjs 64 7 from from IN cord-281487-x0a9qgjs 64 8 14 14 CD cord-281487-x0a9qgjs 64 9 to to TO cord-281487-x0a9qgjs 64 10 53 53 CD cord-281487-x0a9qgjs 64 11 % % NN cord-281487-x0a9qgjs 64 12 in in IN cord-281487-x0a9qgjs 64 13 hospitalized hospitalize VBN cord-281487-x0a9qgjs 64 14 patients patient NNS cord-281487-x0a9qgjs 64 15 with with IN cord-281487-x0a9qgjs 64 16 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 64 17 [ [ -LRB- cord-281487-x0a9qgjs 64 18 34 34 CD cord-281487-x0a9qgjs 64 19 ] ] -RRB- cord-281487-x0a9qgjs 64 20 . . . cord-281487-x0a9qgjs 65 1 Although although IN cord-281487-x0a9qgjs 65 2 liver liver NN cord-281487-x0a9qgjs 65 3 dysfunction dysfunction NN cord-281487-x0a9qgjs 65 4 seems seem VBZ cord-281487-x0a9qgjs 65 5 to to TO cord-281487-x0a9qgjs 65 6 be be VB cord-281487-x0a9qgjs 65 7 mild mild JJ cord-281487-x0a9qgjs 65 8 in in IN cord-281487-x0a9qgjs 65 9 most most JJS cord-281487-x0a9qgjs 65 10 patients patient NNS cord-281487-x0a9qgjs 65 11 , , , cord-281487-x0a9qgjs 65 12 liver liver NN cord-281487-x0a9qgjs 65 13 injury injury NN cord-281487-x0a9qgjs 65 14 , , , cord-281487-x0a9qgjs 65 15 especially especially RB cord-281487-x0a9qgjs 65 16 hepatocellular hepatocellular JJ cord-281487-x0a9qgjs 65 17 type type NN cord-281487-x0a9qgjs 65 18 or or CC cord-281487-x0a9qgjs 65 19 mixed mixed JJ cord-281487-x0a9qgjs 65 20 type type NN cord-281487-x0a9qgjs 65 21 , , , cord-281487-x0a9qgjs 65 22 was be VBD cord-281487-x0a9qgjs 65 23 detrimental detrimental JJ cord-281487-x0a9qgjs 65 24 in in IN cord-281487-x0a9qgjs 65 25 patients patient NNS cord-281487-x0a9qgjs 65 26 with with IN cord-281487-x0a9qgjs 65 27 severe severe JJ cord-281487-x0a9qgjs 65 28 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 65 29 [ [ -LRB- cord-281487-x0a9qgjs 65 30 35 35 CD cord-281487-x0a9qgjs 65 31 ] ] -RRB- cord-281487-x0a9qgjs 65 32 . . . cord-281487-x0a9qgjs 66 1 Liver liver NN cord-281487-x0a9qgjs 66 2 dysfunction dysfunction NN cord-281487-x0a9qgjs 66 3 may may MD cord-281487-x0a9qgjs 66 4 be be VB cord-281487-x0a9qgjs 66 5 caused cause VBN cord-281487-x0a9qgjs 66 6 by by IN cord-281487-x0a9qgjs 66 7 a a DT cord-281487-x0a9qgjs 66 8 direct direct JJ cord-281487-x0a9qgjs 66 9 virus virus NN cord-281487-x0a9qgjs 66 10 - - HYPH cord-281487-x0a9qgjs 66 11 induced induce VBN cord-281487-x0a9qgjs 66 12 injury injury NN cord-281487-x0a9qgjs 66 13 and/or and/or CC cord-281487-x0a9qgjs 66 14 provoked provoke VBD cord-281487-x0a9qgjs 66 15 inflammatory inflammatory JJ cord-281487-x0a9qgjs 66 16 response response NN cord-281487-x0a9qgjs 66 17 [ [ -LRB- cord-281487-x0a9qgjs 66 18 34 34 CD cord-281487-x0a9qgjs 66 19 ] ] -RRB- cord-281487-x0a9qgjs 66 20 . . . cord-281487-x0a9qgjs 67 1 Cai Cai NNP cord-281487-x0a9qgjs 67 2 et et FW cord-281487-x0a9qgjs 67 3 al al NNP cord-281487-x0a9qgjs 67 4 . . NNP cord-281487-x0a9qgjs 67 5 showed show VBD cord-281487-x0a9qgjs 67 6 that that IN cord-281487-x0a9qgjs 67 7 elevated elevated JJ cord-281487-x0a9qgjs 67 8 liver liver NN cord-281487-x0a9qgjs 67 9 enzymes enzyme NNS cord-281487-x0a9qgjs 67 10 and and CC cord-281487-x0a9qgjs 67 11 histopathology histopathology NN cord-281487-x0a9qgjs 67 12 were be VBD cord-281487-x0a9qgjs 67 13 also also RB cord-281487-x0a9qgjs 67 14 associated associate VBN cord-281487-x0a9qgjs 67 15 with with IN cord-281487-x0a9qgjs 67 16 hepatotoxic hepatotoxic JJ cord-281487-x0a9qgjs 67 17 medications medication NNS cord-281487-x0a9qgjs 67 18 in in IN cord-281487-x0a9qgjs 67 19 patients patient NNS cord-281487-x0a9qgjs 67 20 with with IN cord-281487-x0a9qgjs 67 21 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 67 22 [ [ -LRB- cord-281487-x0a9qgjs 67 23 35 35 CD cord-281487-x0a9qgjs 67 24 ] ] -RRB- cord-281487-x0a9qgjs 67 25 . . . cord-281487-x0a9qgjs 68 1 Thus thus RB cord-281487-x0a9qgjs 68 2 , , , cord-281487-x0a9qgjs 68 3 liver liver NN cord-281487-x0a9qgjs 68 4 enzymes enzyme NNS cord-281487-x0a9qgjs 68 5 should should MD cord-281487-x0a9qgjs 68 6 be be VB cord-281487-x0a9qgjs 68 7 frequently frequently RB cord-281487-x0a9qgjs 68 8 monitored monitor VBN cord-281487-x0a9qgjs 68 9 and and CC cord-281487-x0a9qgjs 68 10 efforts effort NNS cord-281487-x0a9qgjs 68 11 considered consider VBN cord-281487-x0a9qgjs 68 12 to to TO cord-281487-x0a9qgjs 68 13 reduce reduce VB cord-281487-x0a9qgjs 68 14 non non JJ cord-281487-x0a9qgjs 68 15 - - JJ cord-281487-x0a9qgjs 68 16 essential essential JJ cord-281487-x0a9qgjs 68 17 medications medication NNS cord-281487-x0a9qgjs 68 18 with with IN cord-281487-x0a9qgjs 68 19 hepatotoxic hepatotoxic JJ cord-281487-x0a9qgjs 68 20 potential potential NN cord-281487-x0a9qgjs 68 21 . . . cord-281487-x0a9qgjs 69 1 Kidney kidney NN cord-281487-x0a9qgjs 69 2 injury injury NN cord-281487-x0a9qgjs 69 3 is be VBZ cord-281487-x0a9qgjs 69 4 common common JJ cord-281487-x0a9qgjs 69 5 in in IN cord-281487-x0a9qgjs 69 6 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 69 7 patients patient NNS cord-281487-x0a9qgjs 69 8 . . . cord-281487-x0a9qgjs 70 1 In in IN cord-281487-x0a9qgjs 70 2 a a DT cord-281487-x0a9qgjs 70 3 study study NN cord-281487-x0a9qgjs 70 4 of of IN cord-281487-x0a9qgjs 70 5 701 701 CD cord-281487-x0a9qgjs 70 6 patients patient NNS cord-281487-x0a9qgjs 70 7 with with IN cord-281487-x0a9qgjs 70 8 COVID-19 covid-19 CD cord-281487-x0a9qgjs 70 9 , , , cord-281487-x0a9qgjs 70 10 14.4 14.4 CD cord-281487-x0a9qgjs 70 11 % % NN cord-281487-x0a9qgjs 70 12 exhibited exhibit VBD cord-281487-x0a9qgjs 70 13 an an DT cord-281487-x0a9qgjs 70 14 elevated elevated JJ cord-281487-x0a9qgjs 70 15 serum serum NN cord-281487-x0a9qgjs 70 16 creatinine creatinine NN cord-281487-x0a9qgjs 70 17 at at IN cord-281487-x0a9qgjs 70 18 admission admission NN cord-281487-x0a9qgjs 70 19 and and CC cord-281487-x0a9qgjs 70 20 5.1 5.1 CD cord-281487-x0a9qgjs 70 21 % % NN cord-281487-x0a9qgjs 70 22 developed develop VBD cord-281487-x0a9qgjs 70 23 acute acute JJ cord-281487-x0a9qgjs 70 24 kidney kidney NN cord-281487-x0a9qgjs 70 25 injury injury NN cord-281487-x0a9qgjs 70 26 ( ( -LRB- cord-281487-x0a9qgjs 70 27 AKI AKI NNP cord-281487-x0a9qgjs 70 28 ) ) -RRB- cord-281487-x0a9qgjs 70 29 during during IN cord-281487-x0a9qgjs 70 30 hospitalization hospitalization NN cord-281487-x0a9qgjs 70 31 [ [ -LRB- cord-281487-x0a9qgjs 70 32 36 36 CD cord-281487-x0a9qgjs 70 33 ] ] -RRB- cord-281487-x0a9qgjs 70 34 . . . cord-281487-x0a9qgjs 71 1 Further further RB cord-281487-x0a9qgjs 71 2 , , , cord-281487-x0a9qgjs 71 3 43.9 43.9 CD cord-281487-x0a9qgjs 71 4 % % NN cord-281487-x0a9qgjs 71 5 had have VBD cord-281487-x0a9qgjs 71 6 proteinuria proteinuria NN cord-281487-x0a9qgjs 71 7 and and CC cord-281487-x0a9qgjs 71 8 26.7 26.7 CD cord-281487-x0a9qgjs 71 9 % % NN cord-281487-x0a9qgjs 71 10 had have VBD cord-281487-x0a9qgjs 71 11 hematuria hematuria NN cord-281487-x0a9qgjs 71 12 at at IN cord-281487-x0a9qgjs 71 13 hospital hospital NN cord-281487-x0a9qgjs 71 14 admission admission NN cord-281487-x0a9qgjs 71 15 [ [ -LRB- cord-281487-x0a9qgjs 71 16 36 36 CD cord-281487-x0a9qgjs 71 17 ] ] -RRB- cord-281487-x0a9qgjs 71 18 . . . cord-281487-x0a9qgjs 72 1 AKI AKI NNP cord-281487-x0a9qgjs 72 2 may may MD cord-281487-x0a9qgjs 72 3 develop develop VB cord-281487-x0a9qgjs 72 4 in in IN cord-281487-x0a9qgjs 72 5 response response NN cord-281487-x0a9qgjs 72 6 to to IN cord-281487-x0a9qgjs 72 7 the the DT cord-281487-x0a9qgjs 72 8 inflammatory inflammatory JJ cord-281487-x0a9qgjs 72 9 phase phase NN cord-281487-x0a9qgjs 72 10 and and CC cord-281487-x0a9qgjs 72 11 cytokine cytokine NN cord-281487-x0a9qgjs 72 12 storm storm NN cord-281487-x0a9qgjs 72 13 , , , cord-281487-x0a9qgjs 72 14 and and CC cord-281487-x0a9qgjs 72 15 be be VB cord-281487-x0a9qgjs 72 16 exacerbated exacerbate VBN cord-281487-x0a9qgjs 72 17 by by IN cord-281487-x0a9qgjs 72 18 hypercoagulation hypercoagulation NN cord-281487-x0a9qgjs 72 19 , , , cord-281487-x0a9qgjs 72 20 microangiopathy microangiopathy NNP cord-281487-x0a9qgjs 72 21 , , , cord-281487-x0a9qgjs 72 22 rhabdomyolysis rhabdomyolysis NN cord-281487-x0a9qgjs 72 23 , , , cord-281487-x0a9qgjs 72 24 acute acute JJ cord-281487-x0a9qgjs 72 25 tubular tubular JJ cord-281487-x0a9qgjs 72 26 necrosis necrosis NN cord-281487-x0a9qgjs 72 27 , , , cord-281487-x0a9qgjs 72 28 hypoxia hypoxia NN cord-281487-x0a9qgjs 72 29 , , , cord-281487-x0a9qgjs 72 30 and and CC cord-281487-x0a9qgjs 72 31 hypotension hypotension NN cord-281487-x0a9qgjs 72 32 [ [ -LRB- cord-281487-x0a9qgjs 72 33 8 8 CD cord-281487-x0a9qgjs 72 34 , , , cord-281487-x0a9qgjs 72 35 37 37 CD cord-281487-x0a9qgjs 72 36 ] ] -RRB- cord-281487-x0a9qgjs 72 37 . . . cord-281487-x0a9qgjs 73 1 Proteinuria Proteinuria NNP cord-281487-x0a9qgjs 73 2 may may MD cord-281487-x0a9qgjs 73 3 be be VB cord-281487-x0a9qgjs 73 4 caused cause VBN cord-281487-x0a9qgjs 73 5 by by IN cord-281487-x0a9qgjs 73 6 direct direct JJ cord-281487-x0a9qgjs 73 7 infection infection NN cord-281487-x0a9qgjs 73 8 of of IN cord-281487-x0a9qgjs 73 9 SARS SARS NNP cord-281487-x0a9qgjs 73 10 - - HYPH cord-281487-x0a9qgjs 73 11 CoV-2 CoV-2 NNP cord-281487-x0a9qgjs 73 12 in in IN cord-281487-x0a9qgjs 73 13 podocytes podocyte NNS cord-281487-x0a9qgjs 73 14 and and CC cord-281487-x0a9qgjs 73 15 proximal proximal JJ cord-281487-x0a9qgjs 73 16 tubular tubular JJ cord-281487-x0a9qgjs 73 17 cells cell NNS cord-281487-x0a9qgjs 73 18 [ [ -LRB- cord-281487-x0a9qgjs 73 19 38 38 CD cord-281487-x0a9qgjs 73 20 ] ] -RRB- cord-281487-x0a9qgjs 73 21 . . . cord-281487-x0a9qgjs 74 1 Patients patient NNS cord-281487-x0a9qgjs 74 2 hospitalized hospitalize VBN cord-281487-x0a9qgjs 74 3 with with IN cord-281487-x0a9qgjs 74 4 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 74 5 pneumonia pneumonia NN cord-281487-x0a9qgjs 75 1 were be VBD cord-281487-x0a9qgjs 75 2 included include VBN cord-281487-x0a9qgjs 75 3 Abbreviations abbreviation NNS cord-281487-x0a9qgjs 75 4 : : : cord-281487-x0a9qgjs 75 5 CHF CHF NNP cord-281487-x0a9qgjs 75 6 , , , cord-281487-x0a9qgjs 75 7 congestive congestive JJ cord-281487-x0a9qgjs 75 8 heart heart NN cord-281487-x0a9qgjs 75 9 failure failure NN cord-281487-x0a9qgjs 75 10 ; ; : cord-281487-x0a9qgjs 75 11 Because because IN cord-281487-x0a9qgjs 75 12 renal renal JJ cord-281487-x0a9qgjs 75 13 abnormalities abnormality NNS cord-281487-x0a9qgjs 75 14 are be VBP cord-281487-x0a9qgjs 75 15 associated associate VBN cord-281487-x0a9qgjs 75 16 with with IN cord-281487-x0a9qgjs 75 17 a a DT cord-281487-x0a9qgjs 75 18 high high JJ cord-281487-x0a9qgjs 75 19 risk risk NN cord-281487-x0a9qgjs 75 20 of of IN cord-281487-x0a9qgjs 75 21 in in IN cord-281487-x0a9qgjs 75 22 - - HYPH cord-281487-x0a9qgjs 75 23 hospital hospital NN cord-281487-x0a9qgjs 75 24 death death NN cord-281487-x0a9qgjs 75 25 and and CC cord-281487-x0a9qgjs 75 26 appear appear VBP cord-281487-x0a9qgjs 75 27 to to TO cord-281487-x0a9qgjs 75 28 be be VB cord-281487-x0a9qgjs 75 29 more more RBR cord-281487-x0a9qgjs 75 30 prevalent prevalent JJ cord-281487-x0a9qgjs 75 31 in in IN cord-281487-x0a9qgjs 75 32 transplant transplant NN cord-281487-x0a9qgjs 75 33 recipients recipient NNS cord-281487-x0a9qgjs 75 34 [ [ -LRB- cord-281487-x0a9qgjs 75 35 36 36 CD cord-281487-x0a9qgjs 75 36 ] ] -RRB- cord-281487-x0a9qgjs 75 37 , , , cord-281487-x0a9qgjs 75 38 serum serum NN cord-281487-x0a9qgjs 75 39 creatinine creatinine NN cord-281487-x0a9qgjs 75 40 and and CC cord-281487-x0a9qgjs 75 41 urinalysis urinalysis NN cord-281487-x0a9qgjs 75 42 should should MD cord-281487-x0a9qgjs 75 43 be be VB cord-281487-x0a9qgjs 75 44 monitored monitor VBN cord-281487-x0a9qgjs 75 45 closely closely RB cord-281487-x0a9qgjs 75 46 . . . cord-281487-x0a9qgjs 76 1 Thrombotic thrombotic JJ cord-281487-x0a9qgjs 76 2 complications complication NNS cord-281487-x0a9qgjs 76 3 have have VBP cord-281487-x0a9qgjs 76 4 been be VBN cord-281487-x0a9qgjs 76 5 reported report VBN cord-281487-x0a9qgjs 76 6 to to TO cord-281487-x0a9qgjs 76 7 occur occur VB cord-281487-x0a9qgjs 76 8 in in IN cord-281487-x0a9qgjs 76 9 31 31 CD cord-281487-x0a9qgjs 76 10 % % NN cord-281487-x0a9qgjs 76 11 of of IN cord-281487-x0a9qgjs 76 12 intensive intensive JJ cord-281487-x0a9qgjs 76 13 care care NN cord-281487-x0a9qgjs 76 14 unit unit NN cord-281487-x0a9qgjs 76 15 ( ( -LRB- cord-281487-x0a9qgjs 76 16 ICU ICU NNP cord-281487-x0a9qgjs 76 17 ) ) -RRB- cord-281487-x0a9qgjs 76 18 patients patient NNS cord-281487-x0a9qgjs 76 19 with with IN cord-281487-x0a9qgjs 76 20 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 76 21 and and CC cord-281487-x0a9qgjs 76 22 pulmonary pulmonary JJ cord-281487-x0a9qgjs 76 23 thromboembolism thromboembolism NN cord-281487-x0a9qgjs 76 24 was be VBD cord-281487-x0a9qgjs 76 25 the the DT cord-281487-x0a9qgjs 76 26 most most RBS cord-281487-x0a9qgjs 76 27 frequent frequent JJ cord-281487-x0a9qgjs 76 28 among among IN cord-281487-x0a9qgjs 76 29 them -PRON- PRP cord-281487-x0a9qgjs 76 30 [ [ -LRB- cord-281487-x0a9qgjs 76 31 39 39 CD cord-281487-x0a9qgjs 76 32 ] ] -RRB- cord-281487-x0a9qgjs 76 33 . . . cord-281487-x0a9qgjs 77 1 Typical typical JJ cord-281487-x0a9qgjs 77 2 findings finding NNS cord-281487-x0a9qgjs 77 3 include include VBP cord-281487-x0a9qgjs 77 4 an an DT cord-281487-x0a9qgjs 77 5 increased increase VBN cord-281487-x0a9qgjs 77 6 D d NN cord-281487-x0a9qgjs 77 7 - - HYPH cord-281487-x0a9qgjs 77 8 dimer dimer JJ cord-281487-x0a9qgjs 77 9 level level NN cord-281487-x0a9qgjs 77 10 , , , cord-281487-x0a9qgjs 77 11 a a DT cord-281487-x0a9qgjs 77 12 relatively relatively RB cord-281487-x0a9qgjs 77 13 modest modest JJ cord-281487-x0a9qgjs 77 14 decrease decrease NN cord-281487-x0a9qgjs 77 15 in in IN cord-281487-x0a9qgjs 77 16 platelet platelet NN cord-281487-x0a9qgjs 77 17 count count NN cord-281487-x0a9qgjs 77 18 , , , cord-281487-x0a9qgjs 77 19 and and CC cord-281487-x0a9qgjs 77 20 a a DT cord-281487-x0a9qgjs 77 21 prolongation prolongation NN cord-281487-x0a9qgjs 77 22 of of IN cord-281487-x0a9qgjs 77 23 the the DT cord-281487-x0a9qgjs 77 24 prothrombin prothrombin JJ cord-281487-x0a9qgjs 77 25 time time NN cord-281487-x0a9qgjs 77 26 in in IN cord-281487-x0a9qgjs 77 27 patients patient NNS cord-281487-x0a9qgjs 77 28 with with IN cord-281487-x0a9qgjs 77 29 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 77 30 [ [ -LRB- cord-281487-x0a9qgjs 77 31 40 40 CD cord-281487-x0a9qgjs 77 32 ] ] -RRB- cord-281487-x0a9qgjs 77 33 . . . cord-281487-x0a9qgjs 78 1 At at IN cord-281487-x0a9qgjs 78 2 autopsy autopsy NN cord-281487-x0a9qgjs 78 3 of of IN cord-281487-x0a9qgjs 78 4 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 78 5 patients patient NNS cord-281487-x0a9qgjs 78 6 , , , cord-281487-x0a9qgjs 78 7 segmental segmental JJ cord-281487-x0a9qgjs 78 8 fibrin fibrin NN cord-281487-x0a9qgjs 78 9 thrombosis thrombosis NN cord-281487-x0a9qgjs 78 10 in in IN cord-281487-x0a9qgjs 78 11 glomeruli glomerulus NNS cord-281487-x0a9qgjs 78 12 was be VBD cord-281487-x0a9qgjs 78 13 observed observe VBN cord-281487-x0a9qgjs 78 14 in in IN cord-281487-x0a9qgjs 78 15 renal renal JJ cord-281487-x0a9qgjs 78 16 findings finding NNS cord-281487-x0a9qgjs 78 17 [ [ -LRB- cord-281487-x0a9qgjs 78 18 41 41 CD cord-281487-x0a9qgjs 78 19 ] ] -RRB- cord-281487-x0a9qgjs 78 20 . . . cord-281487-x0a9qgjs 79 1 Considering consider VBG cord-281487-x0a9qgjs 79 2 that that DT cord-281487-x0a9qgjs 79 3 immobilization immobilization NN cord-281487-x0a9qgjs 79 4 and and CC cord-281487-x0a9qgjs 79 5 vascular vascular JJ cord-281487-x0a9qgjs 79 6 damage damage NN cord-281487-x0a9qgjs 79 7 increase increase VBP cord-281487-x0a9qgjs 79 8 the the DT cord-281487-x0a9qgjs 79 9 risk risk NN cord-281487-x0a9qgjs 79 10 of of IN cord-281487-x0a9qgjs 79 11 thrombosis thrombosis NN cord-281487-x0a9qgjs 79 12 [ [ -LRB- cord-281487-x0a9qgjs 79 13 40 40 CD cord-281487-x0a9qgjs 79 14 ] ] -RRB- cord-281487-x0a9qgjs 79 15 , , , cord-281487-x0a9qgjs 79 16 thrombotic thrombotic JJ cord-281487-x0a9qgjs 79 17 complications complication NNS cord-281487-x0a9qgjs 79 18 of of IN cord-281487-x0a9qgjs 79 19 allografts allograft NNS cord-281487-x0a9qgjs 79 20 may may MD cord-281487-x0a9qgjs 79 21 be be VB cord-281487-x0a9qgjs 79 22 more more RBR cord-281487-x0a9qgjs 79 23 common common JJ cord-281487-x0a9qgjs 79 24 in in IN cord-281487-x0a9qgjs 79 25 transplant transplant NN cord-281487-x0a9qgjs 79 26 recipients recipient NNS cord-281487-x0a9qgjs 79 27 with with IN cord-281487-x0a9qgjs 79 28 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 79 29 . . . cord-281487-x0a9qgjs 80 1 The the DT cord-281487-x0a9qgjs 80 2 International International NNP cord-281487-x0a9qgjs 80 3 Society Society NNP cord-281487-x0a9qgjs 80 4 of of IN cord-281487-x0a9qgjs 80 5 Thrombosis Thrombosis NNP cord-281487-x0a9qgjs 80 6 and and CC cord-281487-x0a9qgjs 80 7 Haemostasis Haemostasis NNP cord-281487-x0a9qgjs 80 8 ( ( -LRB- cord-281487-x0a9qgjs 80 9 ISTH ISTH NNP cord-281487-x0a9qgjs 80 10 ) ) -RRB- cord-281487-x0a9qgjs 80 11 published publish VBD cord-281487-x0a9qgjs 80 12 an an DT cord-281487-x0a9qgjs 80 13 interim interim JJ cord-281487-x0a9qgjs 80 14 guidance guidance NN cord-281487-x0a9qgjs 80 15 statement statement NN cord-281487-x0a9qgjs 80 16 recommending recommend VBG cord-281487-x0a9qgjs 80 17 that that IN cord-281487-x0a9qgjs 80 18 prothrombin prothrombin NN cord-281487-x0a9qgjs 80 19 time time NN cord-281487-x0a9qgjs 80 20 , , , cord-281487-x0a9qgjs 80 21 platelet platelet NN cord-281487-x0a9qgjs 80 22 count count NN cord-281487-x0a9qgjs 80 23 , , , cord-281487-x0a9qgjs 80 24 and and CC cord-281487-x0a9qgjs 80 25 D d NN cord-281487-x0a9qgjs 80 26 - - HYPH cord-281487-x0a9qgjs 80 27 dimer dimer NN cord-281487-x0a9qgjs 80 28 concentrations concentration NNS cord-281487-x0a9qgjs 80 29 should should MD cord-281487-x0a9qgjs 80 30 be be VB cord-281487-x0a9qgjs 80 31 monitored monitor VBN cord-281487-x0a9qgjs 80 32 once once RB cord-281487-x0a9qgjs 80 33 or or CC cord-281487-x0a9qgjs 80 34 twice twice RB cord-281487-x0a9qgjs 80 35 daily daily RB cord-281487-x0a9qgjs 80 36 in in IN cord-281487-x0a9qgjs 80 37 patients patient NNS cord-281487-x0a9qgjs 80 38 with with IN cord-281487-x0a9qgjs 80 39 severe severe JJ cord-281487-x0a9qgjs 80 40 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 80 41 [ [ -LRB- cord-281487-x0a9qgjs 80 42 29 29 CD cord-281487-x0a9qgjs 80 43 ] ] -RRB- cord-281487-x0a9qgjs 80 44 . . . cord-281487-x0a9qgjs 81 1 The the DT cord-281487-x0a9qgjs 81 2 prevalence prevalence NN cord-281487-x0a9qgjs 81 3 of of IN cord-281487-x0a9qgjs 81 4 co co NN cord-281487-x0a9qgjs 81 5 - - NN cord-281487-x0a9qgjs 81 6 infection infection NN cord-281487-x0a9qgjs 81 7 among among IN cord-281487-x0a9qgjs 81 8 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 81 9 patients patient NNS cord-281487-x0a9qgjs 81 10 ranges range VBZ cord-281487-x0a9qgjs 81 11 from from IN cord-281487-x0a9qgjs 81 12 0 0 CD cord-281487-x0a9qgjs 81 13 % % NN cord-281487-x0a9qgjs 81 14 to to TO cord-281487-x0a9qgjs 81 15 45 45 CD cord-281487-x0a9qgjs 81 16 % % NN cord-281487-x0a9qgjs 81 17 overall overall JJ cord-281487-x0a9qgjs 81 18 [ [ -LRB- cord-281487-x0a9qgjs 81 19 42 42 CD cord-281487-x0a9qgjs 81 20 ] ] -RRB- cord-281487-x0a9qgjs 81 21 . . . cord-281487-x0a9qgjs 82 1 In in IN cord-281487-x0a9qgjs 82 2 a a DT cord-281487-x0a9qgjs 82 3 report report NN cord-281487-x0a9qgjs 82 4 by by IN cord-281487-x0a9qgjs 82 5 Zhou Zhou NNP cord-281487-x0a9qgjs 82 6 et et NNP cord-281487-x0a9qgjs 82 7 al al NNP cord-281487-x0a9qgjs 82 8 . . . cord-281487-x0a9qgjs 83 1 , , , cord-281487-x0a9qgjs 83 2 the the DT cord-281487-x0a9qgjs 83 3 incidence incidence NN cord-281487-x0a9qgjs 83 4 of of IN cord-281487-x0a9qgjs 83 5 co co NN cord-281487-x0a9qgjs 83 6 - - NN cord-281487-x0a9qgjs 83 7 infection infection NN cord-281487-x0a9qgjs 83 8 was be VBD cord-281487-x0a9qgjs 83 9 50 50 CD cord-281487-x0a9qgjs 83 10 % % NN cord-281487-x0a9qgjs 83 11 in in IN cord-281487-x0a9qgjs 83 12 non non NNS cord-281487-x0a9qgjs 83 13 - - NNS cord-281487-x0a9qgjs 83 14 survivors survivor NNS cord-281487-x0a9qgjs 83 15 [ [ -LRB- cord-281487-x0a9qgjs 83 16 30 30 CD cord-281487-x0a9qgjs 83 17 ] ] -RRB- cord-281487-x0a9qgjs 83 18 . . . cord-281487-x0a9qgjs 84 1 Bacterial bacterial JJ cord-281487-x0a9qgjs 84 2 , , , cord-281487-x0a9qgjs 84 3 viral viral JJ cord-281487-x0a9qgjs 84 4 and and CC cord-281487-x0a9qgjs 84 5 fungal fungal JJ cord-281487-x0a9qgjs 84 6 infections infection NNS cord-281487-x0a9qgjs 84 7 have have VBP cord-281487-x0a9qgjs 84 8 all all DT cord-281487-x0a9qgjs 84 9 been be VBN cord-281487-x0a9qgjs 84 10 documented document VBN cord-281487-x0a9qgjs 84 11 and and CC cord-281487-x0a9qgjs 84 12 may may MD cord-281487-x0a9qgjs 84 13 need need VB cord-281487-x0a9qgjs 84 14 specialized specialized JJ cord-281487-x0a9qgjs 84 15 diagnostic diagnostic JJ cord-281487-x0a9qgjs 84 16 microbiology microbiology NN cord-281487-x0a9qgjs 84 17 to to TO cord-281487-x0a9qgjs 84 18 identify identify VB cord-281487-x0a9qgjs 84 19 these these DT cord-281487-x0a9qgjs 84 20 serious serious JJ cord-281487-x0a9qgjs 84 21 complications complication NNS cord-281487-x0a9qgjs 84 22 [ [ -LRB- cord-281487-x0a9qgjs 84 23 42 42 CD cord-281487-x0a9qgjs 84 24 ] ] -RRB- cord-281487-x0a9qgjs 84 25 . . . cord-281487-x0a9qgjs 85 1 Most Most JJS cord-281487-x0a9qgjs 85 2 co co NNS cord-281487-x0a9qgjs 85 3 - - NNS cord-281487-x0a9qgjs 85 4 infections infection NNS cord-281487-x0a9qgjs 85 5 occurred occur VBD cord-281487-x0a9qgjs 85 6 within within IN cord-281487-x0a9qgjs 85 7 1−4 1−4 CD cord-281487-x0a9qgjs 85 8 days day NNS cord-281487-x0a9qgjs 85 9 of of IN cord-281487-x0a9qgjs 85 10 onset onset NN cord-281487-x0a9qgjs 85 11 of of IN cord-281487-x0a9qgjs 85 12 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 85 13 disease disease NN cord-281487-x0a9qgjs 85 14 [ [ -LRB- cord-281487-x0a9qgjs 85 15 31 31 CD cord-281487-x0a9qgjs 85 16 ] ] -RRB- cord-281487-x0a9qgjs 85 17 . . . cord-281487-x0a9qgjs 86 1 Generally generally RB cord-281487-x0a9qgjs 86 2 , , , cord-281487-x0a9qgjs 86 3 transplant transplant NN cord-281487-x0a9qgjs 86 4 recipients recipient NNS cord-281487-x0a9qgjs 86 5 experience experience NN cord-281487-x0a9qgjs 86 6 co co NN cord-281487-x0a9qgjs 86 7 - - NN cord-281487-x0a9qgjs 86 8 infection infection NN cord-281487-x0a9qgjs 86 9 more more RBR cord-281487-x0a9qgjs 86 10 commonly commonly RB cord-281487-x0a9qgjs 86 11 than than IN cord-281487-x0a9qgjs 86 12 immunocompetent immunocompetent JJ cord-281487-x0a9qgjs 86 13 individuals individual NNS cord-281487-x0a9qgjs 86 14 [ [ -LRB- cord-281487-x0a9qgjs 86 15 43 43 CD cord-281487-x0a9qgjs 86 16 ] ] -RRB- cord-281487-x0a9qgjs 86 17 . . . cord-281487-x0a9qgjs 87 1 In in IN cord-281487-x0a9qgjs 87 2 a a DT cord-281487-x0a9qgjs 87 3 report report NN cord-281487-x0a9qgjs 87 4 by by IN cord-281487-x0a9qgjs 87 5 Roberts Roberts NNP cord-281487-x0a9qgjs 87 6 et et NNP cord-281487-x0a9qgjs 87 7 al al NNP cord-281487-x0a9qgjs 87 8 . . . cord-281487-x0a9qgjs 88 1 , , , cord-281487-x0a9qgjs 88 2 co co NN cord-281487-x0a9qgjs 88 3 - - NN cord-281487-x0a9qgjs 88 4 infection infection NN cord-281487-x0a9qgjs 88 5 was be VBD cord-281487-x0a9qgjs 88 6 22 22 CD cord-281487-x0a9qgjs 88 7 % % NN cord-281487-x0a9qgjs 88 8 and and CC cord-281487-x0a9qgjs 88 9 35 35 CD cord-281487-x0a9qgjs 88 10 % % NN cord-281487-x0a9qgjs 88 11 in in IN cord-281487-x0a9qgjs 88 12 transplant transplant NN cord-281487-x0a9qgjs 88 13 recipients recipient NNS cord-281487-x0a9qgjs 88 14 with with IN cord-281487-x0a9qgjs 88 15 COVID-19 covid-19 CD cord-281487-x0a9qgjs 88 16 and and CC cord-281487-x0a9qgjs 88 17 those those DT cord-281487-x0a9qgjs 88 18 admitted admit VBN cord-281487-x0a9qgjs 88 19 to to IN cord-281487-x0a9qgjs 88 20 ICU ICU NNP cord-281487-x0a9qgjs 88 21 [ [ -LRB- cord-281487-x0a9qgjs 88 22 12 12 CD cord-281487-x0a9qgjs 88 23 ] ] -RRB- cord-281487-x0a9qgjs 88 24 . . . cord-281487-x0a9qgjs 89 1 Thus thus RB cord-281487-x0a9qgjs 89 2 , , , cord-281487-x0a9qgjs 89 3 transplant transplant NN cord-281487-x0a9qgjs 89 4 recipients recipient NNS cord-281487-x0a9qgjs 89 5 should should MD cord-281487-x0a9qgjs 89 6 be be VB cord-281487-x0a9qgjs 89 7 evaluated evaluate VBN cord-281487-x0a9qgjs 89 8 for for IN cord-281487-x0a9qgjs 89 9 Abbreviations abbreviation NNS cord-281487-x0a9qgjs 89 10 : : : cord-281487-x0a9qgjs 90 1 AST AST NNP cord-281487-x0a9qgjs 90 2 , , , cord-281487-x0a9qgjs 90 3 Aspartate aspartate JJ cord-281487-x0a9qgjs 90 4 amino amino NN cord-281487-x0a9qgjs 90 5 transferase transferase NN cord-281487-x0a9qgjs 90 6 ; ; : cord-281487-x0a9qgjs 90 7 ALT ALT NNP cord-281487-x0a9qgjs 90 8 , , , cord-281487-x0a9qgjs 90 9 Alanine Alanine NNP cord-281487-x0a9qgjs 90 10 amino amino NN cord-281487-x0a9qgjs 90 11 transferase transferase NN cord-281487-x0a9qgjs 90 12 ; ; : cord-281487-x0a9qgjs 90 13 BUN bun NN cord-281487-x0a9qgjs 90 14 , , , cord-281487-x0a9qgjs 90 15 blood blood NN cord-281487-x0a9qgjs 90 16 urea urea NN cord-281487-x0a9qgjs 90 17 nitrogen nitrogen NN cord-281487-x0a9qgjs 90 18 ; ; : cord-281487-x0a9qgjs 90 19 LDH LDH NNP cord-281487-x0a9qgjs 90 20 , , , cord-281487-x0a9qgjs 90 21 Lactate Lactate NNP cord-281487-x0a9qgjs 90 22 dehydrogenase dehydrogenase NN cord-281487-x0a9qgjs 90 23 ; ; : cord-281487-x0a9qgjs 90 24 CPK CPK NNP cord-281487-x0a9qgjs 90 25 , , , cord-281487-x0a9qgjs 90 26 Creatinine creatinine NN cord-281487-x0a9qgjs 90 27 phosphokinase phosphokinase NN cord-281487-x0a9qgjs 90 28 ; ; : cord-281487-x0a9qgjs 90 29 CRP CRP NNP cord-281487-x0a9qgjs 90 30 , , , cord-281487-x0a9qgjs 90 31 C C NNP cord-281487-x0a9qgjs 90 32 - - HYPH cord-281487-x0a9qgjs 90 33 reactive reactive JJ cord-281487-x0a9qgjs 90 34 protein protein NN cord-281487-x0a9qgjs 90 35 ; ; : cord-281487-x0a9qgjs 90 36 IL-6 IL-6 NNP cord-281487-x0a9qgjs 90 37 , , , cord-281487-x0a9qgjs 90 38 interleukin-6 interleukin-6 NNP cord-281487-x0a9qgjs 90 39 ; ; : cord-281487-x0a9qgjs 90 40 CMV CMV NNP cord-281487-x0a9qgjs 90 41 , , , cord-281487-x0a9qgjs 90 42 cytomegalovirus cytomegalovirus NN cord-281487-x0a9qgjs 90 43 ; ; : cord-281487-x0a9qgjs 90 44 ECG ECG NNP cord-281487-x0a9qgjs 90 45 , , , cord-281487-x0a9qgjs 90 46 electrocardiogram electrocardiogram VB cord-281487-x0a9qgjs 90 47 bacterial bacterial JJ cord-281487-x0a9qgjs 90 48 and and CC cord-281487-x0a9qgjs 90 49 opportunistic opportunistic JJ cord-281487-x0a9qgjs 90 50 fungal fungal JJ cord-281487-x0a9qgjs 90 51 infections infection NNS cord-281487-x0a9qgjs 90 52 when when WRB cord-281487-x0a9qgjs 90 53 diagnosed diagnose VBN cord-281487-x0a9qgjs 90 54 with with IN cord-281487-x0a9qgjs 90 55 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 90 56 . . . cord-281487-x0a9qgjs 91 1 Cytomegalovirus Cytomegalovirus NNP cord-281487-x0a9qgjs 91 2 ( ( -LRB- cord-281487-x0a9qgjs 91 3 CMV CMV NNP cord-281487-x0a9qgjs 91 4 ) ) -RRB- cord-281487-x0a9qgjs 91 5 is be VBZ cord-281487-x0a9qgjs 91 6 common common JJ cord-281487-x0a9qgjs 91 7 in in IN cord-281487-x0a9qgjs 91 8 transplant transplant NN cord-281487-x0a9qgjs 91 9 recipients recipient NNS cord-281487-x0a9qgjs 91 10 and and CC cord-281487-x0a9qgjs 91 11 may may MD cord-281487-x0a9qgjs 91 12 reactivate reactivate VB cord-281487-x0a9qgjs 91 13 under under IN cord-281487-x0a9qgjs 91 14 conditions condition NNS cord-281487-x0a9qgjs 91 15 of of IN cord-281487-x0a9qgjs 91 16 stress stress NN cord-281487-x0a9qgjs 91 17 or or CC cord-281487-x0a9qgjs 91 18 augmented augment VBN cord-281487-x0a9qgjs 91 19 immunosuppression immunosuppression NN cord-281487-x0a9qgjs 91 20 [ [ -LRB- cord-281487-x0a9qgjs 91 21 43 43 CD cord-281487-x0a9qgjs 91 22 ] ] -RRB- cord-281487-x0a9qgjs 91 23 . . . cord-281487-x0a9qgjs 92 1 Table table NN cord-281487-x0a9qgjs 92 2 3 3 CD cord-281487-x0a9qgjs 92 3 shows show VBZ cord-281487-x0a9qgjs 92 4 tests test NNS cord-281487-x0a9qgjs 92 5 that that IN cord-281487-x0a9qgjs 92 6 the the DT cord-281487-x0a9qgjs 92 7 JH JH NNP cord-281487-x0a9qgjs 92 8 - - HYPH cord-281487-x0a9qgjs 92 9 CTC CTC NNP cord-281487-x0a9qgjs 92 10 examines examine VBZ cord-281487-x0a9qgjs 92 11 : : : cord-281487-x0a9qgjs 92 12 a a DT cord-281487-x0a9qgjs 92 13 respiratory respiratory JJ cord-281487-x0a9qgjs 92 14 viral viral JJ cord-281487-x0a9qgjs 92 15 panel panel NN cord-281487-x0a9qgjs 92 16 , , , cord-281487-x0a9qgjs 92 17 urine urine NN cord-281487-x0a9qgjs 92 18 legionella legionella NN cord-281487-x0a9qgjs 92 19 and and CC cord-281487-x0a9qgjs 92 20 pneumococcal pneumococcal JJ cord-281487-x0a9qgjs 92 21 antigen antigen NN cord-281487-x0a9qgjs 92 22 , , , cord-281487-x0a9qgjs 92 23 culture culture NN cord-281487-x0a9qgjs 92 24 of of IN cord-281487-x0a9qgjs 92 25 blood blood NN cord-281487-x0a9qgjs 92 26 and and CC cord-281487-x0a9qgjs 92 27 urine urine NN cord-281487-x0a9qgjs 92 28 for for IN cord-281487-x0a9qgjs 92 29 bacteria bacteria NNS cord-281487-x0a9qgjs 92 30 and and CC cord-281487-x0a9qgjs 92 31 fungi fungus NNS cord-281487-x0a9qgjs 92 32 , , , cord-281487-x0a9qgjs 92 33 CMV CMV NNP cord-281487-x0a9qgjs 92 34 antigenemia antigenemia NN cord-281487-x0a9qgjs 92 35 and and CC cord-281487-x0a9qgjs 92 36 PCR PCR NNP cord-281487-x0a9qgjs 92 37 , , , cord-281487-x0a9qgjs 92 38 β β NN cord-281487-x0a9qgjs 92 39 - - HYPH cord-281487-x0a9qgjs 92 40 d d NN cord-281487-x0a9qgjs 92 41 - - HYPH cord-281487-x0a9qgjs 92 42 glucan glucan JJ cord-281487-x0a9qgjs 92 43 and and CC cord-281487-x0a9qgjs 92 44 galactomannan galactomannan NNP cord-281487-x0a9qgjs 92 45 , , , cord-281487-x0a9qgjs 92 46 cryptococcal cryptococcal JJ cord-281487-x0a9qgjs 92 47 antigen antigen NN cord-281487-x0a9qgjs 92 48 , , , cord-281487-x0a9qgjs 92 49 histoplasma histoplasma NN cord-281487-x0a9qgjs 92 50 antigen antigen NN cord-281487-x0a9qgjs 92 51 in in IN cord-281487-x0a9qgjs 92 52 serum serum NN cord-281487-x0a9qgjs 92 53 and and CC cord-281487-x0a9qgjs 92 54 urine urine NN cord-281487-x0a9qgjs 92 55 , , , cord-281487-x0a9qgjs 92 56 Clostridium clostridium NN cord-281487-x0a9qgjs 92 57 difficile difficile NN cord-281487-x0a9qgjs 92 58 toxin toxin NN cord-281487-x0a9qgjs 92 59 assay assay NN cord-281487-x0a9qgjs 92 60 . . . cord-281487-x0a9qgjs 93 1 While while IN cord-281487-x0a9qgjs 93 2 bronchoscopy bronchoscopy NN cord-281487-x0a9qgjs 93 3 is be VBZ cord-281487-x0a9qgjs 93 4 not not RB cord-281487-x0a9qgjs 93 5 routinely routinely RB cord-281487-x0a9qgjs 93 6 available available JJ cord-281487-x0a9qgjs 93 7 , , , cord-281487-x0a9qgjs 93 8 tracheal tracheal JJ cord-281487-x0a9qgjs 93 9 aspirates aspirate NNS cord-281487-x0a9qgjs 93 10 could could MD cord-281487-x0a9qgjs 93 11 be be VB cord-281487-x0a9qgjs 93 12 considered consider VBN cord-281487-x0a9qgjs 93 13 for for IN cord-281487-x0a9qgjs 93 14 intubated intubate VBN cord-281487-x0a9qgjs 93 15 patients patient NNS cord-281487-x0a9qgjs 93 16 to to TO cord-281487-x0a9qgjs 93 17 obtain obtain VB cord-281487-x0a9qgjs 93 18 microbiological microbiological JJ cord-281487-x0a9qgjs 93 19 samples sample NNS cord-281487-x0a9qgjs 93 20 . . . cord-281487-x0a9qgjs 94 1 In in IN cord-281487-x0a9qgjs 94 2 instances instance NNS cord-281487-x0a9qgjs 94 3 where where WRB cord-281487-x0a9qgjs 94 4 the the DT cord-281487-x0a9qgjs 94 5 risk risk NN cord-281487-x0a9qgjs 94 6 of of IN cord-281487-x0a9qgjs 94 7 diagnostic diagnostic JJ cord-281487-x0a9qgjs 94 8 procedures procedure NNS cord-281487-x0a9qgjs 94 9 may may MD cord-281487-x0a9qgjs 94 10 be be VB cord-281487-x0a9qgjs 94 11 precluded preclude VBN cord-281487-x0a9qgjs 94 12 sample sample NN cord-281487-x0a9qgjs 94 13 collection collection NN cord-281487-x0a9qgjs 94 14 , , , cord-281487-x0a9qgjs 94 15 empiric empiric JJ cord-281487-x0a9qgjs 94 16 antibiotics antibiotic NNS cord-281487-x0a9qgjs 94 17 , , , cord-281487-x0a9qgjs 94 18 anti anti NNS cord-281487-x0a9qgjs 94 19 - - NNS cord-281487-x0a9qgjs 94 20 fungals fungal NNS cord-281487-x0a9qgjs 94 21 , , , cord-281487-x0a9qgjs 94 22 or or CC cord-281487-x0a9qgjs 94 23 anti anti NNS cord-281487-x0a9qgjs 94 24 - - NNS cord-281487-x0a9qgjs 94 25 virals viral NNS cord-281487-x0a9qgjs 94 26 should should MD cord-281487-x0a9qgjs 94 27 be be VB cord-281487-x0a9qgjs 94 28 carefully carefully RB cord-281487-x0a9qgjs 94 29 considered consider VBN cord-281487-x0a9qgjs 94 30 based base VBN cord-281487-x0a9qgjs 94 31 on on IN cord-281487-x0a9qgjs 94 32 the the DT cord-281487-x0a9qgjs 94 33 organ organ NN cord-281487-x0a9qgjs 94 34 - - HYPH cord-281487-x0a9qgjs 94 35 specific specific JJ cord-281487-x0a9qgjs 94 36 pathogen pathogen NN cord-281487-x0a9qgjs 94 37 risks risk NNS cord-281487-x0a9qgjs 94 38 . . . cord-281487-x0a9qgjs 95 1 An an DT cord-281487-x0a9qgjs 95 2 increase increase NN cord-281487-x0a9qgjs 95 3 of of IN cord-281487-x0a9qgjs 95 4 the the DT cord-281487-x0a9qgjs 95 5 procalcitonin procalcitonin JJ cord-281487-x0a9qgjs 95 6 level level NN cord-281487-x0a9qgjs 95 7 reflects reflect VBZ cord-281487-x0a9qgjs 95 8 bacterial bacterial JJ cord-281487-x0a9qgjs 95 9 coinfection coinfection NN cord-281487-x0a9qgjs 95 10 and and CC cord-281487-x0a9qgjs 95 11 predicts predict VBZ cord-281487-x0a9qgjs 95 12 the the DT cord-281487-x0a9qgjs 95 13 progression progression NN cord-281487-x0a9qgjs 95 14 toward toward IN cord-281487-x0a9qgjs 95 15 severe severe JJ cord-281487-x0a9qgjs 95 16 disease disease NN cord-281487-x0a9qgjs 95 17 [ [ -LRB- cord-281487-x0a9qgjs 95 18 44 44 CD cord-281487-x0a9qgjs 95 19 ] ] -RRB- cord-281487-x0a9qgjs 95 20 . . . cord-281487-x0a9qgjs 96 1 Previously previously RB cord-281487-x0a9qgjs 96 2 published publish VBN cord-281487-x0a9qgjs 96 3 literatures literature NNS cord-281487-x0a9qgjs 96 4 suggest suggest VBP cord-281487-x0a9qgjs 96 5 that that IN cord-281487-x0a9qgjs 96 6 procalcitonin procalcitonin NNS cord-281487-x0a9qgjs 96 7 levels level NNS cord-281487-x0a9qgjs 96 8 may may MD cord-281487-x0a9qgjs 96 9 be be VB cord-281487-x0a9qgjs 96 10 comparatively comparatively RB cord-281487-x0a9qgjs 96 11 higher high JJR cord-281487-x0a9qgjs 96 12 in in IN cord-281487-x0a9qgjs 96 13 transplant transplant NN cord-281487-x0a9qgjs 96 14 recipients recipient NNS cord-281487-x0a9qgjs 96 15 with with IN cord-281487-x0a9qgjs 96 16 COVID-19 covid-19 CD cord-281487-x0a9qgjs 96 17 than than IN cord-281487-x0a9qgjs 96 18 in in IN cord-281487-x0a9qgjs 96 19 the the DT cord-281487-x0a9qgjs 96 20 general general JJ cord-281487-x0a9qgjs 96 21 population population NN cord-281487-x0a9qgjs 96 22 with with IN cord-281487-x0a9qgjs 96 23 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 96 24 ( ( -LRB- cord-281487-x0a9qgjs 96 25 Table table NN cord-281487-x0a9qgjs 96 26 2 2 CD cord-281487-x0a9qgjs 96 27 ) ) -RRB- cord-281487-x0a9qgjs 96 28 [ [ -LRB- cord-281487-x0a9qgjs 96 29 11 11 CD cord-281487-x0a9qgjs 96 30 , , , cord-281487-x0a9qgjs 96 31 17 17 CD cord-281487-x0a9qgjs 96 32 , , , cord-281487-x0a9qgjs 96 33 18 18 CD cord-281487-x0a9qgjs 96 34 , , , cord-281487-x0a9qgjs 96 35 21 21 CD cord-281487-x0a9qgjs 96 36 , , , cord-281487-x0a9qgjs 96 37 23 23 CD cord-281487-x0a9qgjs 96 38 , , , cord-281487-x0a9qgjs 96 39 24 24 CD cord-281487-x0a9qgjs 96 40 ] ] -RRB- cord-281487-x0a9qgjs 96 41 . . . cord-281487-x0a9qgjs 97 1 The the DT cord-281487-x0a9qgjs 97 2 monitoring monitoring NN cord-281487-x0a9qgjs 97 3 of of IN cord-281487-x0a9qgjs 97 4 procalcitonin procalcitonin NNS cord-281487-x0a9qgjs 97 5 may may MD cord-281487-x0a9qgjs 97 6 play play VB cord-281487-x0a9qgjs 97 7 a a DT cord-281487-x0a9qgjs 97 8 role role NN cord-281487-x0a9qgjs 97 9 in in IN cord-281487-x0a9qgjs 97 10 predicting predict VBG cord-281487-x0a9qgjs 97 11 bacterial bacterial JJ cord-281487-x0a9qgjs 97 12 infection infection NN cord-281487-x0a9qgjs 97 13 in in IN cord-281487-x0a9qgjs 97 14 the the DT cord-281487-x0a9qgjs 97 15 absence absence NN cord-281487-x0a9qgjs 97 16 of of IN cord-281487-x0a9qgjs 97 17 direct direct JJ cord-281487-x0a9qgjs 97 18 microbiology microbiology NN cord-281487-x0a9qgjs 97 19 . . . cord-281487-x0a9qgjs 98 1 Chest chest NN cord-281487-x0a9qgjs 98 2 radiography radiography NN cord-281487-x0a9qgjs 98 3 plays play VBZ cord-281487-x0a9qgjs 98 4 an an DT cord-281487-x0a9qgjs 98 5 important important JJ cord-281487-x0a9qgjs 98 6 role role NN cord-281487-x0a9qgjs 98 7 in in IN cord-281487-x0a9qgjs 98 8 the the DT cord-281487-x0a9qgjs 98 9 diagnosis diagnosis NN cord-281487-x0a9qgjs 98 10 of of IN cord-281487-x0a9qgjs 98 11 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 98 12 . . . cord-281487-x0a9qgjs 99 1 Abnormal abnormal JJ cord-281487-x0a9qgjs 99 2 findings finding NNS cord-281487-x0a9qgjs 99 3 on on IN cord-281487-x0a9qgjs 99 4 chest chest NN cord-281487-x0a9qgjs 99 5 radiography radiography NN cord-281487-x0a9qgjs 99 6 were be VBD cord-281487-x0a9qgjs 99 7 identified identify VBN cord-281487-x0a9qgjs 99 8 in in IN cord-281487-x0a9qgjs 99 9 up up IN cord-281487-x0a9qgjs 99 10 to to TO cord-281487-x0a9qgjs 99 11 76.5 76.5 CD cord-281487-x0a9qgjs 99 12 % % NN cord-281487-x0a9qgjs 99 13 of of IN cord-281487-x0a9qgjs 99 14 individuals individual NNS cord-281487-x0a9qgjs 99 15 , , , cord-281487-x0a9qgjs 99 16 and and CC cord-281487-x0a9qgjs 99 17 abnormalities abnormality NNS cord-281487-x0a9qgjs 99 18 on on IN cord-281487-x0a9qgjs 99 19 chest chest NN cord-281487-x0a9qgjs 99 20 computed compute VBN cord-281487-x0a9qgjs 99 21 tomography tomography NN cord-281487-x0a9qgjs 99 22 ( ( -LRB- cord-281487-x0a9qgjs 99 23 CT CT NNP cord-281487-x0a9qgjs 99 24 ) ) -RRB- cord-281487-x0a9qgjs 99 25 were be VBD cord-281487-x0a9qgjs 99 26 84.4 84.4 CD cord-281487-x0a9qgjs 99 27 % % NN cord-281487-x0a9qgjs 99 28 and and CC cord-281487-x0a9qgjs 99 29 94.6 94.6 CD cord-281487-x0a9qgjs 99 30 % % NN cord-281487-x0a9qgjs 99 31 among among IN cord-281487-x0a9qgjs 99 32 patients patient NNS cord-281487-x0a9qgjs 99 33 with with IN cord-281487-x0a9qgjs 99 34 non non JJ cord-281487-x0a9qgjs 99 35 - - JJ cord-281487-x0a9qgjs 99 36 severe severe JJ cord-281487-x0a9qgjs 99 37 COVID-19 covid-19 NN cord-281487-x0a9qgjs 99 38 and and CC cord-281487-x0a9qgjs 99 39 patients patient NNS cord-281487-x0a9qgjs 99 40 with with IN cord-281487-x0a9qgjs 99 41 severe severe JJ cord-281487-x0a9qgjs 99 42 COVID-19 covid-19 NN cord-281487-x0a9qgjs 99 43 , , , cord-281487-x0a9qgjs 99 44 respectively respectively RB cord-281487-x0a9qgjs 99 45 [ [ -LRB- cord-281487-x0a9qgjs 99 46 14 14 CD cord-281487-x0a9qgjs 99 47 ] ] -RRB- cord-281487-x0a9qgjs 99 48 . . . cord-281487-x0a9qgjs 100 1 Despite despite IN cord-281487-x0a9qgjs 100 2 a a DT cord-281487-x0a9qgjs 100 3 higher high JJR cord-281487-x0a9qgjs 100 4 sensitivity sensitivity NN cord-281487-x0a9qgjs 100 5 , , , cord-281487-x0a9qgjs 100 6 the the DT cord-281487-x0a9qgjs 100 7 infectious infectious JJ cord-281487-x0a9qgjs 100 8 precautions precaution NNS cord-281487-x0a9qgjs 100 9 needed need VBN cord-281487-x0a9qgjs 100 10 to to TO cord-281487-x0a9qgjs 100 11 safely safely RB cord-281487-x0a9qgjs 100 12 transport transport VB cord-281487-x0a9qgjs 100 13 patients patient NNS cord-281487-x0a9qgjs 100 14 with with IN cord-281487-x0a9qgjs 100 15 COVID-19 covid-19 VB cord-281487-x0a9qgjs 100 16 and and CC cord-281487-x0a9qgjs 100 17 decontaminate decontaminate VB cord-281487-x0a9qgjs 100 18 equipment equipment NN cord-281487-x0a9qgjs 100 19 necessitate necessitate VBP cord-281487-x0a9qgjs 100 20 thoughtful thoughtful JJ cord-281487-x0a9qgjs 100 21 consideration consideration NN cord-281487-x0a9qgjs 100 22 of of IN cord-281487-x0a9qgjs 100 23 the the DT cord-281487-x0a9qgjs 100 24 optimal optimal JJ cord-281487-x0a9qgjs 100 25 use use NN cord-281487-x0a9qgjs 100 26 of of IN cord-281487-x0a9qgjs 100 27 CT CT NNP cord-281487-x0a9qgjs 100 28 [ [ -LRB- cord-281487-x0a9qgjs 100 29 45 45 CD cord-281487-x0a9qgjs 100 30 , , , cord-281487-x0a9qgjs 100 31 46 46 CD cord-281487-x0a9qgjs 100 32 ] ] -RRB- cord-281487-x0a9qgjs 100 33 . . . cord-281487-x0a9qgjs 101 1 Alternative alternative JJ cord-281487-x0a9qgjs 101 2 modalities modality NNS cord-281487-x0a9qgjs 101 3 such such JJ cord-281487-x0a9qgjs 101 4 as as IN cord-281487-x0a9qgjs 101 5 lung lung NN cord-281487-x0a9qgjs 101 6 ultrasonography ultrasonography NN cord-281487-x0a9qgjs 101 7 may may MD cord-281487-x0a9qgjs 101 8 provide provide VB cord-281487-x0a9qgjs 101 9 results result NNS cord-281487-x0a9qgjs 101 10 similar similar JJ cord-281487-x0a9qgjs 101 11 to to IN cord-281487-x0a9qgjs 101 12 chest chest NN cord-281487-x0a9qgjs 101 13 CT CT NNP cord-281487-x0a9qgjs 101 14 to to TO cord-281487-x0a9qgjs 101 15 assess assess VB cord-281487-x0a9qgjs 101 16 pneumonia pneumonia NN cord-281487-x0a9qgjs 101 17 and and CC cord-281487-x0a9qgjs 101 18 reduce reduce VB cord-281487-x0a9qgjs 101 19 staff staff NN cord-281487-x0a9qgjs 101 20 / / SYM cord-281487-x0a9qgjs 101 21 equipment equipment NN cord-281487-x0a9qgjs 101 22 exposure exposure NN cord-281487-x0a9qgjs 101 23 [ [ -LRB- cord-281487-x0a9qgjs 101 24 46 46 CD cord-281487-x0a9qgjs 101 25 ] ] -RRB- cord-281487-x0a9qgjs 101 26 [ [ -LRB- cord-281487-x0a9qgjs 101 27 47 47 CD cord-281487-x0a9qgjs 101 28 ] ] -RRB- cord-281487-x0a9qgjs 101 29 [ [ -LRB- cord-281487-x0a9qgjs 101 30 48 48 CD cord-281487-x0a9qgjs 101 31 ] ] -RRB- cord-281487-x0a9qgjs 101 32 . . . cord-281487-x0a9qgjs 102 1 However however RB cord-281487-x0a9qgjs 102 2 , , , cord-281487-x0a9qgjs 102 3 CT CT NNP cord-281487-x0a9qgjs 102 4 may may MD cord-281487-x0a9qgjs 102 5 still still RB cord-281487-x0a9qgjs 102 6 have have VB cord-281487-x0a9qgjs 102 7 a a DT cord-281487-x0a9qgjs 102 8 valuable valuable JJ cord-281487-x0a9qgjs 102 9 role role NN cord-281487-x0a9qgjs 102 10 in in IN cord-281487-x0a9qgjs 102 11 the the DT cord-281487-x0a9qgjs 102 12 evaluation evaluation NN cord-281487-x0a9qgjs 102 13 of of IN cord-281487-x0a9qgjs 102 14 pulmonary pulmonary JJ cord-281487-x0a9qgjs 102 15 emboli emboli NN cord-281487-x0a9qgjs 102 16 and/or and/or CC cord-281487-x0a9qgjs 102 17 diagnosis diagnosis NN cord-281487-x0a9qgjs 102 18 of of IN cord-281487-x0a9qgjs 102 19 pneumonia pneumonia NN cord-281487-x0a9qgjs 102 20 when when WRB cord-281487-x0a9qgjs 102 21 other other JJ cord-281487-x0a9qgjs 102 22 modalities modality NNS cord-281487-x0a9qgjs 102 23 are be VBP cord-281487-x0a9qgjs 102 24 non non JJ cord-281487-x0a9qgjs 102 25 - - JJ cord-281487-x0a9qgjs 102 26 diagnostic diagnostic JJ cord-281487-x0a9qgjs 102 27 . . . cord-281487-x0a9qgjs 103 1 Further further JJ cord-281487-x0a9qgjs 103 2 studies study NNS cord-281487-x0a9qgjs 103 3 are be VBP cord-281487-x0a9qgjs 103 4 required require VBN cord-281487-x0a9qgjs 103 5 to to TO cord-281487-x0a9qgjs 103 6 determine determine VB cord-281487-x0a9qgjs 103 7 the the DT cord-281487-x0a9qgjs 103 8 optimal optimal JJ cord-281487-x0a9qgjs 103 9 use use NN cord-281487-x0a9qgjs 103 10 of of IN cord-281487-x0a9qgjs 103 11 imaging imaging NN cord-281487-x0a9qgjs 103 12 in in IN cord-281487-x0a9qgjs 103 13 managing manage VBG cord-281487-x0a9qgjs 103 14 the the DT cord-281487-x0a9qgjs 103 15 care care NN cord-281487-x0a9qgjs 103 16 of of IN cord-281487-x0a9qgjs 103 17 the the DT cord-281487-x0a9qgjs 103 18 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 103 19 transplant transplant NN cord-281487-x0a9qgjs 103 20 recipient recipient NN cord-281487-x0a9qgjs 103 21 . . . cord-281487-x0a9qgjs 104 1 Evolving evolve VBG cord-281487-x0a9qgjs 104 2 knowledge knowledge NN cord-281487-x0a9qgjs 104 3 of of IN cord-281487-x0a9qgjs 104 4 viral viral JJ cord-281487-x0a9qgjs 104 5 transmission transmission NN cord-281487-x0a9qgjs 104 6 informs inform VBZ cord-281487-x0a9qgjs 104 7 the the DT cord-281487-x0a9qgjs 104 8 approach approach NN cord-281487-x0a9qgjs 104 9 to to IN cord-281487-x0a9qgjs 104 10 the the DT cord-281487-x0a9qgjs 104 11 management management NN cord-281487-x0a9qgjs 104 12 of of IN cord-281487-x0a9qgjs 104 13 transplant transplant NN cord-281487-x0a9qgjs 104 14 recipients recipient NNS cord-281487-x0a9qgjs 104 15 with with IN cord-281487-x0a9qgjs 104 16 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 104 17 . . . cord-281487-x0a9qgjs 105 1 The the DT cord-281487-x0a9qgjs 105 2 median median JJ cord-281487-x0a9qgjs 105 3 incubation incubation NN cord-281487-x0a9qgjs 105 4 period period NN cord-281487-x0a9qgjs 105 5 of of IN cord-281487-x0a9qgjs 105 6 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 105 7 is be VBZ cord-281487-x0a9qgjs 105 8 estimated estimate VBN cord-281487-x0a9qgjs 105 9 to to TO cord-281487-x0a9qgjs 105 10 be be VB cord-281487-x0a9qgjs 105 11 5.1 5.1 CD cord-281487-x0a9qgjs 105 12 days day NNS cord-281487-x0a9qgjs 105 13 and and CC cord-281487-x0a9qgjs 105 14 the the DT cord-281487-x0a9qgjs 105 15 majority majority NN cord-281487-x0a9qgjs 105 16 of of IN cord-281487-x0a9qgjs 105 17 symptomatic symptomatic JJ cord-281487-x0a9qgjs 105 18 patients patient NNS cord-281487-x0a9qgjs 105 19 develop develop VBP cord-281487-x0a9qgjs 105 20 symptoms symptom NNS cord-281487-x0a9qgjs 105 21 within within IN cord-281487-x0a9qgjs 105 22 11 11 CD cord-281487-x0a9qgjs 105 23 days day NNS cord-281487-x0a9qgjs 105 24 [ [ -LRB- cord-281487-x0a9qgjs 105 25 49 49 CD cord-281487-x0a9qgjs 105 26 ] ] -RRB- cord-281487-x0a9qgjs 105 27 . . . cord-281487-x0a9qgjs 106 1 Moreover moreover RB cord-281487-x0a9qgjs 106 2 , , , cord-281487-x0a9qgjs 106 3 the the DT cord-281487-x0a9qgjs 106 4 infectiousness infectiousness NN cord-281487-x0a9qgjs 106 5 of of IN cord-281487-x0a9qgjs 106 6 SARS SARS NNP cord-281487-x0a9qgjs 106 7 - - HYPH cord-281487-x0a9qgjs 106 8 CoV-2 CoV-2 NNP cord-281487-x0a9qgjs 106 9 starts start VBZ cord-281487-x0a9qgjs 106 10 from from IN cord-281487-x0a9qgjs 106 11 2.3 2.3 CD cord-281487-x0a9qgjs 106 12 days day NNS cord-281487-x0a9qgjs 106 13 before before IN cord-281487-x0a9qgjs 106 14 symptom symptom NN cord-281487-x0a9qgjs 106 15 onset onset NN cord-281487-x0a9qgjs 106 16 and and CC cord-281487-x0a9qgjs 106 17 up up IN cord-281487-x0a9qgjs 106 18 to to TO cord-281487-x0a9qgjs 106 19 10 10 CD cord-281487-x0a9qgjs 106 20 days day NNS cord-281487-x0a9qgjs 106 21 after after IN cord-281487-x0a9qgjs 106 22 resolution resolution NN cord-281487-x0a9qgjs 106 23 of of IN cord-281487-x0a9qgjs 106 24 symptoms symptom NNS cord-281487-x0a9qgjs 106 25 in in IN cord-281487-x0a9qgjs 106 26 the the DT cord-281487-x0a9qgjs 106 27 immunocompetent immunocompetent JJ cord-281487-x0a9qgjs 106 28 host host NN cord-281487-x0a9qgjs 106 29 , , , cord-281487-x0a9qgjs 106 30 but but CC cord-281487-x0a9qgjs 106 31 possibly possibly RB cord-281487-x0a9qgjs 106 32 up up IN cord-281487-x0a9qgjs 106 33 to to TO cord-281487-x0a9qgjs 106 34 4 4 CD cord-281487-x0a9qgjs 106 35 weeks week NNS cord-281487-x0a9qgjs 106 36 in in IN cord-281487-x0a9qgjs 106 37 immunocompromised immunocompromised JJ cord-281487-x0a9qgjs 106 38 hosts host NNS cord-281487-x0a9qgjs 106 39 . . . cord-281487-x0a9qgjs 107 1 Unfortunately unfortunately RB cord-281487-x0a9qgjs 107 2 , , , cord-281487-x0a9qgjs 107 3 44 44 CD cord-281487-x0a9qgjs 107 4 % % NN cord-281487-x0a9qgjs 107 5 of of IN cord-281487-x0a9qgjs 107 6 infection infection NN cord-281487-x0a9qgjs 107 7 occurs occur VBZ cord-281487-x0a9qgjs 107 8 at at IN cord-281487-x0a9qgjs 107 9 the the DT cord-281487-x0a9qgjs 107 10 pre pre JJ cord-281487-x0a9qgjs 107 11 - - JJ cord-281487-x0a9qgjs 107 12 symptomatic symptomatic JJ cord-281487-x0a9qgjs 107 13 phase phase NN cord-281487-x0a9qgjs 107 14 [ [ -LRB- cord-281487-x0a9qgjs 107 15 50 50 CD cord-281487-x0a9qgjs 107 16 ] ] -RRB- cord-281487-x0a9qgjs 107 17 , , , cord-281487-x0a9qgjs 107 18 and and CC cord-281487-x0a9qgjs 107 19 due due IN cord-281487-x0a9qgjs 107 20 to to IN cord-281487-x0a9qgjs 107 21 its -PRON- PRP$ cord-281487-x0a9qgjs 107 22 high high JJ cord-281487-x0a9qgjs 107 23 transmissibility transmissibility NN cord-281487-x0a9qgjs 107 24 in in IN cord-281487-x0a9qgjs 107 25 droplets droplet NNS cord-281487-x0a9qgjs 107 26 , , , cord-281487-x0a9qgjs 107 27 contact contact NN cord-281487-x0a9qgjs 107 28 and and CC cord-281487-x0a9qgjs 107 29 aerosols aerosol NNS cord-281487-x0a9qgjs 107 30 , , , cord-281487-x0a9qgjs 107 31 preventive preventive JJ cord-281487-x0a9qgjs 107 32 precautions precaution NNS cord-281487-x0a9qgjs 107 33 are be VBP cord-281487-x0a9qgjs 107 34 critical critical JJ cord-281487-x0a9qgjs 107 35 . . . cord-281487-x0a9qgjs 108 1 Respiratory respiratory JJ cord-281487-x0a9qgjs 108 2 droplets droplet NNS cord-281487-x0a9qgjs 108 3 , , , cord-281487-x0a9qgjs 108 4 the the DT cord-281487-x0a9qgjs 108 5 most most RBS cord-281487-x0a9qgjs 108 6 common common JJ cord-281487-x0a9qgjs 108 7 mode mode NN cord-281487-x0a9qgjs 108 8 of of IN cord-281487-x0a9qgjs 108 9 transmission transmission NN cord-281487-x0a9qgjs 108 10 , , , cord-281487-x0a9qgjs 108 11 are be VBP cord-281487-x0a9qgjs 108 12 formed form VBN cord-281487-x0a9qgjs 108 13 when when WRB cord-281487-x0a9qgjs 108 14 an an DT cord-281487-x0a9qgjs 108 15 infected infected JJ cord-281487-x0a9qgjs 108 16 patient patient NN cord-281487-x0a9qgjs 108 17 sneezes sneeze VBZ cord-281487-x0a9qgjs 108 18 , , , cord-281487-x0a9qgjs 108 19 coughs cough NNS cord-281487-x0a9qgjs 108 20 , , , cord-281487-x0a9qgjs 108 21 or or CC cord-281487-x0a9qgjs 108 22 even even RB cord-281487-x0a9qgjs 108 23 talks talk NNS cord-281487-x0a9qgjs 108 24 , , , cord-281487-x0a9qgjs 108 25 and and CC cord-281487-x0a9qgjs 108 26 viral viral JJ cord-281487-x0a9qgjs 108 27 particles particle NNS cord-281487-x0a9qgjs 108 28 are be VBP cord-281487-x0a9qgjs 108 29 directly directly RB cord-281487-x0a9qgjs 108 30 inhaled inhale VBN cord-281487-x0a9qgjs 108 31 , , , cord-281487-x0a9qgjs 108 32 or or CC cord-281487-x0a9qgjs 108 33 when when WRB cord-281487-x0a9qgjs 108 34 an an DT cord-281487-x0a9qgjs 108 35 uninfected uninfected JJ cord-281487-x0a9qgjs 108 36 individual individual NN cord-281487-x0a9qgjs 108 37 touches touch VBZ cord-281487-x0a9qgjs 108 38 a a DT cord-281487-x0a9qgjs 108 39 contaminated contaminate VBN cord-281487-x0a9qgjs 108 40 surface surface NN cord-281487-x0a9qgjs 108 41 and and CC cord-281487-x0a9qgjs 108 42 subsequently subsequently RB cord-281487-x0a9qgjs 108 43 their -PRON- PRP$ cord-281487-x0a9qgjs 108 44 mucous mucous JJ cord-281487-x0a9qgjs 108 45 membranes membrane NNS cord-281487-x0a9qgjs 108 46 [ [ -LRB- cord-281487-x0a9qgjs 108 47 51 51 CD cord-281487-x0a9qgjs 108 48 ] ] -RRB- cord-281487-x0a9qgjs 108 49 . . . cord-281487-x0a9qgjs 109 1 Transmission transmission NN cord-281487-x0a9qgjs 109 2 through through IN cord-281487-x0a9qgjs 109 3 respiratory respiratory JJ cord-281487-x0a9qgjs 109 4 droplet droplet NN cord-281487-x0a9qgjs 109 5 may may MD cord-281487-x0a9qgjs 109 6 be be VB cord-281487-x0a9qgjs 109 7 reduced reduce VBN cord-281487-x0a9qgjs 109 8 with with IN cord-281487-x0a9qgjs 109 9 the the DT cord-281487-x0a9qgjs 109 10 use use NN cord-281487-x0a9qgjs 109 11 of of IN cord-281487-x0a9qgjs 109 12 surgical surgical JJ cord-281487-x0a9qgjs 109 13 or or CC cord-281487-x0a9qgjs 109 14 cloth cloth JJ cord-281487-x0a9qgjs 109 15 masks mask NNS cord-281487-x0a9qgjs 109 16 , , , cord-281487-x0a9qgjs 109 17 and and CC cord-281487-x0a9qgjs 109 18 thus thus RB cord-281487-x0a9qgjs 109 19 transplant transplant NN cord-281487-x0a9qgjs 109 20 recipients recipient NNS cord-281487-x0a9qgjs 109 21 should should MD cord-281487-x0a9qgjs 109 22 ensure ensure VB cord-281487-x0a9qgjs 109 23 that that IN cord-281487-x0a9qgjs 109 24 they -PRON- PRP cord-281487-x0a9qgjs 109 25 and and CC cord-281487-x0a9qgjs 109 26 all all DT cord-281487-x0a9qgjs 109 27 individuals individual NNS cord-281487-x0a9qgjs 109 28 outside outside IN cord-281487-x0a9qgjs 109 29 of of IN cord-281487-x0a9qgjs 109 30 their -PRON- PRP$ cord-281487-x0a9qgjs 109 31 household household NN cord-281487-x0a9qgjs 109 32 are be VBP cord-281487-x0a9qgjs 109 33 wearing wear VBG cord-281487-x0a9qgjs 109 34 masks mask NNS cord-281487-x0a9qgjs 109 35 during during IN cord-281487-x0a9qgjs 109 36 an an DT cord-281487-x0a9qgjs 109 37 in in IN cord-281487-x0a9qgjs 109 38 - - HYPH cord-281487-x0a9qgjs 109 39 person person NN cord-281487-x0a9qgjs 109 40 encounter encounter NN cord-281487-x0a9qgjs 109 41 [ [ -LRB- cord-281487-x0a9qgjs 109 42 52 52 CD cord-281487-x0a9qgjs 109 43 ] ] -RRB- cord-281487-x0a9qgjs 109 44 . . . cord-281487-x0a9qgjs 110 1 Further further RB cord-281487-x0a9qgjs 110 2 , , , cord-281487-x0a9qgjs 110 3 hand hand NN cord-281487-x0a9qgjs 110 4 hygiene hygiene NN cord-281487-x0a9qgjs 110 5 is be VBZ cord-281487-x0a9qgjs 110 6 essential essential JJ cord-281487-x0a9qgjs 110 7 to to TO cord-281487-x0a9qgjs 110 8 reduce reduce VB cord-281487-x0a9qgjs 110 9 transmission transmission NN cord-281487-x0a9qgjs 110 10 from from IN cord-281487-x0a9qgjs 110 11 contact contact NN cord-281487-x0a9qgjs 110 12 surfaces surface NNS cord-281487-x0a9qgjs 110 13 , , , cord-281487-x0a9qgjs 110 14 as as IN cord-281487-x0a9qgjs 110 15 SARS SARS NNP cord-281487-x0a9qgjs 110 16 - - HYPH cord-281487-x0a9qgjs 110 17 CoV-2 CoV-2 NNP cord-281487-x0a9qgjs 110 18 can can MD cord-281487-x0a9qgjs 110 19 be be VB cord-281487-x0a9qgjs 110 20 detectable detectable JJ cord-281487-x0a9qgjs 110 21 on on IN cord-281487-x0a9qgjs 110 22 the the DT cord-281487-x0a9qgjs 110 23 surface surface NN cord-281487-x0a9qgjs 110 24 of of IN cord-281487-x0a9qgjs 110 25 the the DT cord-281487-x0a9qgjs 110 26 plastic plastic NN cord-281487-x0a9qgjs 110 27 and and CC cord-281487-x0a9qgjs 110 28 stainless stainless JJ cord-281487-x0a9qgjs 110 29 steel steel NN cord-281487-x0a9qgjs 110 30 up up IN cord-281487-x0a9qgjs 110 31 to to TO cord-281487-x0a9qgjs 110 32 72 72 CD cord-281487-x0a9qgjs 110 33 h h NN cord-281487-x0a9qgjs 110 34 [ [ -LRB- cord-281487-x0a9qgjs 110 35 52 52 CD cord-281487-x0a9qgjs 110 36 ] ] -RRB- cord-281487-x0a9qgjs 110 37 . . . cord-281487-x0a9qgjs 111 1 Given give VBN cord-281487-x0a9qgjs 111 2 the the DT cord-281487-x0a9qgjs 111 3 higher high JJR cord-281487-x0a9qgjs 111 4 risk risk NN cord-281487-x0a9qgjs 111 5 of of IN cord-281487-x0a9qgjs 111 6 serious serious JJ cord-281487-x0a9qgjs 111 7 complications complication NNS cord-281487-x0a9qgjs 111 8 from from IN cord-281487-x0a9qgjs 111 9 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 111 10 , , , cord-281487-x0a9qgjs 111 11 we -PRON- PRP cord-281487-x0a9qgjs 111 12 recommend recommend VBP cord-281487-x0a9qgjs 111 13 that that IN cord-281487-x0a9qgjs 111 14 patients patient NNS cord-281487-x0a9qgjs 111 15 and and CC cord-281487-x0a9qgjs 111 16 household household NN cord-281487-x0a9qgjs 111 17 contacts contact NNS cord-281487-x0a9qgjs 111 18 receive receive VBP cord-281487-x0a9qgjs 111 19 ongoing ongoing JJ cord-281487-x0a9qgjs 111 20 education education NN cord-281487-x0a9qgjs 111 21 : : : cord-281487-x0a9qgjs 111 22 the the DT cord-281487-x0a9qgjs 111 23 importance importance NN cord-281487-x0a9qgjs 111 24 of of IN cord-281487-x0a9qgjs 111 25 exposure exposure NN cord-281487-x0a9qgjs 111 26 prevention prevention NN cord-281487-x0a9qgjs 111 27 and and CC cord-281487-x0a9qgjs 111 28 risk risk NN cord-281487-x0a9qgjs 111 29 reduction reduction NN cord-281487-x0a9qgjs 111 30 measures measure NNS cord-281487-x0a9qgjs 111 31 , , , cord-281487-x0a9qgjs 111 32 as as IN cord-281487-x0a9qgjs 111 33 these these DT cord-281487-x0a9qgjs 111 34 behaviors behavior NNS cord-281487-x0a9qgjs 111 35 may may MD cord-281487-x0a9qgjs 111 36 erode erode VB cord-281487-x0a9qgjs 111 37 over over IN cord-281487-x0a9qgjs 111 38 time time NN cord-281487-x0a9qgjs 111 39 . . . cord-281487-x0a9qgjs 112 1 The the DT cord-281487-x0a9qgjs 112 2 complexity complexity NN cord-281487-x0a9qgjs 112 3 of of IN cord-281487-x0a9qgjs 112 4 routine routine JJ cord-281487-x0a9qgjs 112 5 transplant transplant NN cord-281487-x0a9qgjs 112 6 care care NN cord-281487-x0a9qgjs 112 7 in in IN cord-281487-x0a9qgjs 112 8 monitoring monitor VBG cord-281487-x0a9qgjs 112 9 allograft allograft NN cord-281487-x0a9qgjs 112 10 function function NN cord-281487-x0a9qgjs 112 11 , , , cord-281487-x0a9qgjs 112 12 toxicities toxicity NNS cord-281487-x0a9qgjs 112 13 , , , cord-281487-x0a9qgjs 112 14 and and CC cord-281487-x0a9qgjs 112 15 general general JJ cord-281487-x0a9qgjs 112 16 health health NN cord-281487-x0a9qgjs 112 17 has have VBZ cord-281487-x0a9qgjs 112 18 necessitated necessitate VBN cord-281487-x0a9qgjs 112 19 a a DT cord-281487-x0a9qgjs 112 20 reimagining reimagining NN cord-281487-x0a9qgjs 112 21 of of IN cord-281487-x0a9qgjs 112 22 health health NN cord-281487-x0a9qgjs 112 23 care care NN cord-281487-x0a9qgjs 112 24 delivery delivery NN cord-281487-x0a9qgjs 112 25 during during IN cord-281487-x0a9qgjs 112 26 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 112 27 pandemic pandemic NN cord-281487-x0a9qgjs 112 28 . . . cord-281487-x0a9qgjs 113 1 In in IN cord-281487-x0a9qgjs 113 2 this this DT cord-281487-x0a9qgjs 113 3 regard regard NN cord-281487-x0a9qgjs 113 4 , , , cord-281487-x0a9qgjs 113 5 centers center NNS cord-281487-x0a9qgjs 113 6 have have VBP cord-281487-x0a9qgjs 113 7 instituted institute VBN cord-281487-x0a9qgjs 113 8 telemedicine telemedicine NN cord-281487-x0a9qgjs 113 9 , , , cord-281487-x0a9qgjs 113 10 limited limit VBN cord-281487-x0a9qgjs 113 11 in in IN cord-281487-x0a9qgjs 113 12 - - HYPH cord-281487-x0a9qgjs 113 13 person person NN cord-281487-x0a9qgjs 113 14 visits visit NNS cord-281487-x0a9qgjs 113 15 , , , cord-281487-x0a9qgjs 113 16 and and CC cord-281487-x0a9qgjs 113 17 increased increase VBN cord-281487-x0a9qgjs 113 18 remote remote JJ cord-281487-x0a9qgjs 113 19 monitoring monitoring NN cord-281487-x0a9qgjs 113 20 allows allow VBZ cord-281487-x0a9qgjs 113 21 uninterrupted uninterrupted JJ cord-281487-x0a9qgjs 113 22 outpatient outpatient NN cord-281487-x0a9qgjs 113 23 care care NN cord-281487-x0a9qgjs 113 24 while while IN cord-281487-x0a9qgjs 113 25 limiting limit VBG cord-281487-x0a9qgjs 113 26 direct direct JJ cord-281487-x0a9qgjs 113 27 patient patient NN cord-281487-x0a9qgjs 113 28 contact contact NN cord-281487-x0a9qgjs 113 29 to to IN cord-281487-x0a9qgjs 113 30 highest high JJS cord-281487-x0a9qgjs 113 31 priority priority NN cord-281487-x0a9qgjs 113 32 individuals individual NNS cord-281487-x0a9qgjs 113 33 . . . cord-281487-x0a9qgjs 114 1 With with IN cord-281487-x0a9qgjs 114 2 these these DT cord-281487-x0a9qgjs 114 3 tools tool NNS cord-281487-x0a9qgjs 114 4 , , , cord-281487-x0a9qgjs 114 5 limited limited JJ cord-281487-x0a9qgjs 114 6 ambulatory ambulatory JJ cord-281487-x0a9qgjs 114 7 care care NN cord-281487-x0a9qgjs 114 8 then then RB cord-281487-x0a9qgjs 114 9 ideally ideally RB cord-281487-x0a9qgjs 114 10 be be VB cord-281487-x0a9qgjs 114 11 provided provide VBN cord-281487-x0a9qgjs 114 12 in in IN cord-281487-x0a9qgjs 114 13 social social JJ cord-281487-x0a9qgjs 114 14 distanced distance VBN cord-281487-x0a9qgjs 114 15 settings setting NNS cord-281487-x0a9qgjs 114 16 with with IN cord-281487-x0a9qgjs 114 17 appropriate appropriate JJ cord-281487-x0a9qgjs 114 18 COVID−19 COVID−19 NNP cord-281487-x0a9qgjs 114 19 screening screening NN cord-281487-x0a9qgjs 114 20 to to TO cord-281487-x0a9qgjs 114 21 reduce reduce VB cord-281487-x0a9qgjs 114 22 nosocomial nosocomial JJ cord-281487-x0a9qgjs 114 23 transmission transmission NN cord-281487-x0a9qgjs 114 24 risk risk NN cord-281487-x0a9qgjs 114 25 [ [ -LRB- cord-281487-x0a9qgjs 114 26 53 53 CD cord-281487-x0a9qgjs 114 27 ] ] -RRB- cord-281487-x0a9qgjs 114 28 . . . cord-281487-x0a9qgjs 115 1 Telemedicine telemedicine NN cord-281487-x0a9qgjs 115 2 can can MD cord-281487-x0a9qgjs 115 3 be be VB cord-281487-x0a9qgjs 115 4 performed perform VBN cord-281487-x0a9qgjs 115 5 using use VBG cord-281487-x0a9qgjs 115 6 a a DT cord-281487-x0a9qgjs 115 7 combination combination NN cord-281487-x0a9qgjs 115 8 of of IN cord-281487-x0a9qgjs 115 9 synchronous synchronous JJ cord-281487-x0a9qgjs 115 10 , , , cord-281487-x0a9qgjs 115 11 asynchronous asynchronous JJ cord-281487-x0a9qgjs 115 12 , , , cord-281487-x0a9qgjs 115 13 or or CC cord-281487-x0a9qgjs 115 14 remote remote JJ cord-281487-x0a9qgjs 115 15 monitoring monitoring NN cord-281487-x0a9qgjs 115 16 . . . cord-281487-x0a9qgjs 116 1 Synchronous synchronous JJ cord-281487-x0a9qgjs 116 2 refers refer VBZ cord-281487-x0a9qgjs 116 3 to to IN cord-281487-x0a9qgjs 116 4 real real JJ cord-281487-x0a9qgjs 116 5 - - HYPH cord-281487-x0a9qgjs 116 6 time time NN cord-281487-x0a9qgjs 116 7 encounters encounter NNS cord-281487-x0a9qgjs 116 8 via via IN cord-281487-x0a9qgjs 116 9 telephone telephone NN cord-281487-x0a9qgjs 116 10 or or CC cord-281487-x0a9qgjs 116 11 audio audio JJ cord-281487-x0a9qgjs 116 12 - - HYPH cord-281487-x0a9qgjs 116 13 video video NN cord-281487-x0a9qgjs 116 14 interaction interaction NN cord-281487-x0a9qgjs 116 15 . . . cord-281487-x0a9qgjs 117 1 Asynchronous asynchronous JJ cord-281487-x0a9qgjs 117 2 telemedicine telemedicine NN cord-281487-x0a9qgjs 117 3 is be VBZ cord-281487-x0a9qgjs 117 4 a a DT cord-281487-x0a9qgjs 117 5 " " `` cord-281487-x0a9qgjs 117 6 store store NN cord-281487-x0a9qgjs 117 7 - - HYPH cord-281487-x0a9qgjs 117 8 and and CC cord-281487-x0a9qgjs 117 9 - - HYPH cord-281487-x0a9qgjs 117 10 forward forward NN cord-281487-x0a9qgjs 117 11 " " '' cord-281487-x0a9qgjs 117 12 technique technique NN cord-281487-x0a9qgjs 117 13 that that WDT cord-281487-x0a9qgjs 117 14 sends send VBZ cord-281487-x0a9qgjs 117 15 the the DT cord-281487-x0a9qgjs 117 16 collected collect VBN cord-281487-x0a9qgjs 117 17 data datum NNS cord-281487-x0a9qgjs 117 18 and and CC cord-281487-x0a9qgjs 117 19 images image NNS cord-281487-x0a9qgjs 117 20 to to IN cord-281487-x0a9qgjs 117 21 clinicians clinician NNS cord-281487-x0a9qgjs 117 22 . . . cord-281487-x0a9qgjs 118 1 Remote remote JJ cord-281487-x0a9qgjs 118 2 patient patient NN cord-281487-x0a9qgjs 118 3 monitoring monitoring NN cord-281487-x0a9qgjs 118 4 refers refer VBZ cord-281487-x0a9qgjs 118 5 to to IN cord-281487-x0a9qgjs 118 6 the the DT cord-281487-x0a9qgjs 118 7 direct direct JJ cord-281487-x0a9qgjs 118 8 transmission transmission NN cord-281487-x0a9qgjs 118 9 of of IN cord-281487-x0a9qgjs 118 10 a a DT cord-281487-x0a9qgjs 118 11 patient patient NN cord-281487-x0a9qgjs 118 12 's 's POS cord-281487-x0a9qgjs 118 13 clinical clinical JJ cord-281487-x0a9qgjs 118 14 measurements measurement NNS cord-281487-x0a9qgjs 118 15 to to IN cord-281487-x0a9qgjs 118 16 their -PRON- PRP$ cord-281487-x0a9qgjs 118 17 healthcare healthcare NN cord-281487-x0a9qgjs 118 18 provider provider NN cord-281487-x0a9qgjs 118 19 [ [ -LRB- cord-281487-x0a9qgjs 118 20 52 52 CD cord-281487-x0a9qgjs 118 21 ] ] -RRB- cord-281487-x0a9qgjs 118 22 . . . cord-281487-x0a9qgjs 119 1 Telemedicine telemedicine NN cord-281487-x0a9qgjs 119 2 may may MD cord-281487-x0a9qgjs 119 3 also also RB cord-281487-x0a9qgjs 119 4 be be VB cord-281487-x0a9qgjs 119 5 an an DT cord-281487-x0a9qgjs 119 6 important important JJ cord-281487-x0a9qgjs 119 7 component component NN cord-281487-x0a9qgjs 119 8 of of IN cord-281487-x0a9qgjs 119 9 preparation preparation NN cord-281487-x0a9qgjs 119 10 for for IN cord-281487-x0a9qgjs 119 11 in in IN cord-281487-x0a9qgjs 119 12 - - HYPH cord-281487-x0a9qgjs 119 13 person person NN cord-281487-x0a9qgjs 119 14 encounters encounter VBZ cord-281487-x0a9qgjs 119 15 to to TO cord-281487-x0a9qgjs 119 16 reduce reduce VB cord-281487-x0a9qgjs 119 17 the the DT cord-281487-x0a9qgjs 119 18 amount amount NN cord-281487-x0a9qgjs 119 19 of of IN cord-281487-x0a9qgjs 119 20 time time NN cord-281487-x0a9qgjs 119 21 spent spend VBN cord-281487-x0a9qgjs 119 22 in in IN cord-281487-x0a9qgjs 119 23 direct direct JJ cord-281487-x0a9qgjs 119 24 patient patient NN cord-281487-x0a9qgjs 119 25 contact contact NN cord-281487-x0a9qgjs 119 26 and and CC cord-281487-x0a9qgjs 119 27 to to TO cord-281487-x0a9qgjs 119 28 conduct conduct VB cord-281487-x0a9qgjs 119 29 necessary necessary JJ cord-281487-x0a9qgjs 119 30 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 119 31 symptom symptom NN cord-281487-x0a9qgjs 119 32 and and CC cord-281487-x0a9qgjs 119 33 behavior behavior NN cord-281487-x0a9qgjs 119 34 risk risk NN cord-281487-x0a9qgjs 119 35 screening screening NN cord-281487-x0a9qgjs 119 36 ( ( -LRB- cord-281487-x0a9qgjs 119 37 Fig Fig NNP cord-281487-x0a9qgjs 119 38 . . . cord-281487-x0a9qgjs 119 39 1 1 CD cord-281487-x0a9qgjs 119 40 ) ) -RRB- cord-281487-x0a9qgjs 119 41 [ [ -LRB- cord-281487-x0a9qgjs 119 42 54 54 CD cord-281487-x0a9qgjs 119 43 , , , cord-281487-x0a9qgjs 119 44 55 55 CD cord-281487-x0a9qgjs 119 45 ] ] -RRB- cord-281487-x0a9qgjs 119 46 . . . cord-281487-x0a9qgjs 120 1 For for IN cord-281487-x0a9qgjs 120 2 maximum maximum JJ cord-281487-x0a9qgjs 120 3 utility utility NN cord-281487-x0a9qgjs 120 4 , , , cord-281487-x0a9qgjs 120 5 transplant transplant NN cord-281487-x0a9qgjs 120 6 centers center NNS cord-281487-x0a9qgjs 120 7 may may MD cord-281487-x0a9qgjs 120 8 need need VB cord-281487-x0a9qgjs 120 9 to to TO cord-281487-x0a9qgjs 120 10 invest invest VB cord-281487-x0a9qgjs 120 11 in in IN cord-281487-x0a9qgjs 120 12 resources resource NNS cord-281487-x0a9qgjs 120 13 for for IN cord-281487-x0a9qgjs 120 14 patient patient JJ cord-281487-x0a9qgjs 120 15 self self NN cord-281487-x0a9qgjs 120 16 - - HYPH cord-281487-x0a9qgjs 120 17 monitoring monitoring NN cord-281487-x0a9qgjs 120 18 , , , cord-281487-x0a9qgjs 120 19 including include VBG cord-281487-x0a9qgjs 120 20 tools tool NNS cord-281487-x0a9qgjs 120 21 for for IN cord-281487-x0a9qgjs 120 22 vital vital JJ cord-281487-x0a9qgjs 120 23 signs sign NNS cord-281487-x0a9qgjs 120 24 monitoring monitor VBG cord-281487-x0a9qgjs 120 25 , , , cord-281487-x0a9qgjs 120 26 technology technology NN cord-281487-x0a9qgjs 120 27 platforms platform NNS cord-281487-x0a9qgjs 120 28 , , , cord-281487-x0a9qgjs 120 29 and and CC cord-281487-x0a9qgjs 120 30 resources resource NNS cord-281487-x0a9qgjs 120 31 to to TO cord-281487-x0a9qgjs 120 32 document document VB cord-281487-x0a9qgjs 120 33 objective objective JJ cord-281487-x0a9qgjs 120 34 findings finding NNS cord-281487-x0a9qgjs 120 35 . . . cord-281487-x0a9qgjs 121 1 The the DT cord-281487-x0a9qgjs 121 2 frequency frequency NN cord-281487-x0a9qgjs 121 3 of of IN cord-281487-x0a9qgjs 121 4 routine routine JJ cord-281487-x0a9qgjs 121 5 laboratory laboratory NN cord-281487-x0a9qgjs 121 6 testing testing NN cord-281487-x0a9qgjs 121 7 , , , cord-281487-x0a9qgjs 121 8 routine routine JJ cord-281487-x0a9qgjs 121 9 health health NN cord-281487-x0a9qgjs 121 10 maintenance maintenance NN cord-281487-x0a9qgjs 121 11 tests test NNS cord-281487-x0a9qgjs 121 12 , , , cord-281487-x0a9qgjs 121 13 and and CC cord-281487-x0a9qgjs 121 14 cancer cancer NN cord-281487-x0a9qgjs 121 15 screening screening NN cord-281487-x0a9qgjs 121 16 should should MD cord-281487-x0a9qgjs 121 17 be be VB cord-281487-x0a9qgjs 121 18 considered consider VBN cord-281487-x0a9qgjs 121 19 to to TO cord-281487-x0a9qgjs 121 20 balance balance VB cord-281487-x0a9qgjs 121 21 the the DT cord-281487-x0a9qgjs 121 22 infection infection NN cord-281487-x0a9qgjs 121 23 risk risk NN cord-281487-x0a9qgjs 121 24 of of IN cord-281487-x0a9qgjs 121 25 SARS SARS NNP cord-281487-x0a9qgjs 121 26 - - HYPH cord-281487-x0a9qgjs 121 27 CoV-2 CoV-2 NNP cord-281487-x0a9qgjs 121 28 with with IN cord-281487-x0a9qgjs 121 29 the the DT cord-281487-x0a9qgjs 121 30 risk risk NN cord-281487-x0a9qgjs 121 31 to to TO cord-281487-x0a9qgjs 121 32 health health VB cord-281487-x0a9qgjs 121 33 if if IN cord-281487-x0a9qgjs 121 34 these these DT cord-281487-x0a9qgjs 121 35 diagnostics diagnostic NNS cord-281487-x0a9qgjs 121 36 are be VBP cord-281487-x0a9qgjs 121 37 deferred defer VBN cord-281487-x0a9qgjs 121 38 . . . cord-281487-x0a9qgjs 122 1 Ideally ideally RB cord-281487-x0a9qgjs 122 2 , , , cord-281487-x0a9qgjs 122 3 when when WRB cord-281487-x0a9qgjs 122 4 required require VBN cord-281487-x0a9qgjs 122 5 , , , cord-281487-x0a9qgjs 122 6 diagnostic diagnostic JJ cord-281487-x0a9qgjs 122 7 tests test NNS cord-281487-x0a9qgjs 122 8 should should MD cord-281487-x0a9qgjs 122 9 be be VB cord-281487-x0a9qgjs 122 10 performed perform VBN cord-281487-x0a9qgjs 122 11 at at IN cord-281487-x0a9qgjs 122 12 a a DT cord-281487-x0a9qgjs 122 13 facility facility NN cord-281487-x0a9qgjs 122 14 that that WDT cord-281487-x0a9qgjs 122 15 practices practice VBZ cord-281487-x0a9qgjs 122 16 mitigation mitigation NN cord-281487-x0a9qgjs 122 17 behaviors behavior NNS cord-281487-x0a9qgjs 122 18 such such JJ cord-281487-x0a9qgjs 122 19 as as IN cord-281487-x0a9qgjs 122 20 a a DT cord-281487-x0a9qgjs 122 21 restricted restricted JJ cord-281487-x0a9qgjs 122 22 number number NN cord-281487-x0a9qgjs 122 23 of of IN cord-281487-x0a9qgjs 122 24 persons person NNS cord-281487-x0a9qgjs 122 25 in in IN cord-281487-x0a9qgjs 122 26 waiting wait VBG cord-281487-x0a9qgjs 122 27 rooms room NNS cord-281487-x0a9qgjs 122 28 , , , cord-281487-x0a9qgjs 122 29 scheduled schedule VBN cord-281487-x0a9qgjs 122 30 appointments appointment NNS cord-281487-x0a9qgjs 122 31 , , , cord-281487-x0a9qgjs 122 32 and and CC cord-281487-x0a9qgjs 122 33 strict strict JJ cord-281487-x0a9qgjs 122 34 screening screening NN cord-281487-x0a9qgjs 122 35 of of IN cord-281487-x0a9qgjs 122 36 patients patient NNS cord-281487-x0a9qgjs 122 37 for for IN cord-281487-x0a9qgjs 122 38 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 122 39 . . . cord-281487-x0a9qgjs 122 40 Collaboration collaboration NN cord-281487-x0a9qgjs 122 41 between between IN cord-281487-x0a9qgjs 122 42 transplantation transplantation NN cord-281487-x0a9qgjs 122 43 specialists specialist NNS cord-281487-x0a9qgjs 122 44 , , , cord-281487-x0a9qgjs 122 45 monitoring monitoring NN cord-281487-x0a9qgjs 122 46 of of IN cord-281487-x0a9qgjs 122 47 local local JJ cord-281487-x0a9qgjs 122 48 COVID covid JJ cord-281487-x0a9qgjs 122 49 infection infection NN cord-281487-x0a9qgjs 122 50 rates rate NNS cord-281487-x0a9qgjs 122 51 , , , cord-281487-x0a9qgjs 122 52 and and CC cord-281487-x0a9qgjs 122 53 the the DT cord-281487-x0a9qgjs 122 54 local local JJ cord-281487-x0a9qgjs 122 55 health health NN cord-281487-x0a9qgjs 122 56 care care NN cord-281487-x0a9qgjs 122 57 provider provider NN cord-281487-x0a9qgjs 122 58 may may MD cord-281487-x0a9qgjs 122 59 be be VB cord-281487-x0a9qgjs 122 60 required require VBN cord-281487-x0a9qgjs 122 61 [ [ -LRB- cord-281487-x0a9qgjs 122 62 54 54 CD cord-281487-x0a9qgjs 122 63 , , , cord-281487-x0a9qgjs 122 64 56 56 CD cord-281487-x0a9qgjs 122 65 ] ] -RRB- cord-281487-x0a9qgjs 122 66 . . . cord-281487-x0a9qgjs 123 1 The the DT cord-281487-x0a9qgjs 123 2 frequency frequency NN cord-281487-x0a9qgjs 123 3 of of IN cord-281487-x0a9qgjs 123 4 allograft allograft NN cord-281487-x0a9qgjs 123 5 surveillance surveillance NN cord-281487-x0a9qgjs 123 6 biopsies biopsy NNS cord-281487-x0a9qgjs 123 7 should should MD cord-281487-x0a9qgjs 123 8 be be VB cord-281487-x0a9qgjs 123 9 determined determine VBN cord-281487-x0a9qgjs 123 10 to to TO cord-281487-x0a9qgjs 123 11 take take VB cord-281487-x0a9qgjs 123 12 into into IN cord-281487-x0a9qgjs 123 13 account account NN cord-281487-x0a9qgjs 123 14 the the DT cord-281487-x0a9qgjs 123 15 individual individual JJ cord-281487-x0a9qgjs 123 16 risks risk NNS cord-281487-x0a9qgjs 123 17 and and CC cord-281487-x0a9qgjs 123 18 benefits benefit NNS cord-281487-x0a9qgjs 123 19 , , , cord-281487-x0a9qgjs 123 20 especially especially RB cord-281487-x0a9qgjs 123 21 during during IN cord-281487-x0a9qgjs 123 22 this this DT cord-281487-x0a9qgjs 123 23 epidemic epidemic NN cord-281487-x0a9qgjs 123 24 period period NN cord-281487-x0a9qgjs 123 25 . . . cord-281487-x0a9qgjs 124 1 When when WRB cord-281487-x0a9qgjs 124 2 available available JJ cord-281487-x0a9qgjs 124 3 , , , cord-281487-x0a9qgjs 124 4 non non JJ cord-281487-x0a9qgjs 124 5 - - JJ cord-281487-x0a9qgjs 124 6 invasive invasive JJ cord-281487-x0a9qgjs 124 7 technologies technology NNS cord-281487-x0a9qgjs 124 8 such such JJ cord-281487-x0a9qgjs 124 9 as as IN cord-281487-x0a9qgjs 124 10 donor donor NN cord-281487-x0a9qgjs 124 11 - - HYPH cord-281487-x0a9qgjs 124 12 derived derive VBN cord-281487-x0a9qgjs 124 13 cell cell NN cord-281487-x0a9qgjs 124 14 - - HYPH cord-281487-x0a9qgjs 124 15 free free JJ cord-281487-x0a9qgjs 124 16 DNA dna NN cord-281487-x0a9qgjs 124 17 ( ( -LRB- cord-281487-x0a9qgjs 124 18 dd dd NN cord-281487-x0a9qgjs 124 19 - - HYPH cord-281487-x0a9qgjs 124 20 cfDNA cfdna RBS cord-281487-x0a9qgjs 124 21 ) ) -RRB- cord-281487-x0a9qgjs 124 22 , , , cord-281487-x0a9qgjs 124 23 gene gene NN cord-281487-x0a9qgjs 124 24 expression expression NN cord-281487-x0a9qgjs 124 25 profiles profile NNS cord-281487-x0a9qgjs 124 26 , , , cord-281487-x0a9qgjs 124 27 and and CC cord-281487-x0a9qgjs 124 28 home home NN cord-281487-x0a9qgjs 124 29 spirometry spirometry NN cord-281487-x0a9qgjs 124 30 may may MD cord-281487-x0a9qgjs 124 31 allow allow VB cord-281487-x0a9qgjs 124 32 transplant transplant NN cord-281487-x0a9qgjs 124 33 recipients recipient NNS cord-281487-x0a9qgjs 124 34 to to TO cord-281487-x0a9qgjs 124 35 reduce reduce VB cord-281487-x0a9qgjs 124 36 invasive invasive JJ cord-281487-x0a9qgjs 124 37 procedures procedure NNS cord-281487-x0a9qgjs 124 38 for for IN cord-281487-x0a9qgjs 124 39 rejection rejection NN cord-281487-x0a9qgjs 124 40 monitoring monitoring NN cord-281487-x0a9qgjs 124 41 . . . cord-281487-x0a9qgjs 125 1 In in IN cord-281487-x0a9qgjs 125 2 KT KT NNP cord-281487-x0a9qgjs 125 3 recipients recipient NNS cord-281487-x0a9qgjs 125 4 , , , cord-281487-x0a9qgjs 125 5 the the DT cord-281487-x0a9qgjs 125 6 negative negative JJ cord-281487-x0a9qgjs 125 7 predictive predictive JJ cord-281487-x0a9qgjs 125 8 value value NN cord-281487-x0a9qgjs 125 9 of of IN cord-281487-x0a9qgjs 125 10 dd dd NN cord-281487-x0a9qgjs 125 11 - - HYPH cord-281487-x0a9qgjs 125 12 cfDNA cfdna JJ cord-281487-x0a9qgjs 125 13 for for IN cord-281487-x0a9qgjs 125 14 any any DT cord-281487-x0a9qgjs 125 15 active active JJ cord-281487-x0a9qgjs 125 16 rejection rejection NN cord-281487-x0a9qgjs 125 17 at at IN cord-281487-x0a9qgjs 125 18 a a DT cord-281487-x0a9qgjs 125 19 cutoff cutoff NN cord-281487-x0a9qgjs 125 20 of of IN cord-281487-x0a9qgjs 125 21 1.0 1.0 CD cord-281487-x0a9qgjs 125 22 % % NN cord-281487-x0a9qgjs 125 23 was be VBD cord-281487-x0a9qgjs 125 24 84 84 CD cord-281487-x0a9qgjs 125 25 % % NN cord-281487-x0a9qgjs 125 26 , , , cord-281487-x0a9qgjs 125 27 and and CC cord-281487-x0a9qgjs 125 28 thus thus RB cord-281487-x0a9qgjs 125 29 may may MD cord-281487-x0a9qgjs 125 30 be be VB cord-281487-x0a9qgjs 125 31 a a DT cord-281487-x0a9qgjs 125 32 good good JJ cord-281487-x0a9qgjs 125 33 non non JJ cord-281487-x0a9qgjs 125 34 - - JJ cord-281487-x0a9qgjs 125 35 invasive invasive JJ cord-281487-x0a9qgjs 125 36 marker marker NN cord-281487-x0a9qgjs 125 37 of of IN cord-281487-x0a9qgjs 125 38 allograft allograft NN cord-281487-x0a9qgjs 125 39 surveillance surveillance NN cord-281487-x0a9qgjs 125 40 [ [ -LRB- cord-281487-x0a9qgjs 125 41 57 57 CD cord-281487-x0a9qgjs 125 42 ] ] -RRB- cord-281487-x0a9qgjs 125 43 . . . cord-281487-x0a9qgjs 126 1 While while IN cord-281487-x0a9qgjs 126 2 its -PRON- PRP$ cord-281487-x0a9qgjs 126 3 role role NN cord-281487-x0a9qgjs 126 4 in in IN cord-281487-x0a9qgjs 126 5 other other JJ cord-281487-x0a9qgjs 126 6 solid solid JJ cord-281487-x0a9qgjs 126 7 organ organ NN cord-281487-x0a9qgjs 126 8 transplants transplant NNS cord-281487-x0a9qgjs 126 9 is be VBZ cord-281487-x0a9qgjs 126 10 still still RB cord-281487-x0a9qgjs 126 11 being be VBG cord-281487-x0a9qgjs 126 12 defined define VBN cord-281487-x0a9qgjs 126 13 , , , cord-281487-x0a9qgjs 126 14 peripheral peripheral JJ cord-281487-x0a9qgjs 126 15 gene gene NN cord-281487-x0a9qgjs 126 16 expression expression NN cord-281487-x0a9qgjs 126 17 tests test NNS cord-281487-x0a9qgjs 126 18 may may MD cord-281487-x0a9qgjs 126 19 also also RB cord-281487-x0a9qgjs 126 20 be be VB cord-281487-x0a9qgjs 126 21 helpful helpful JJ cord-281487-x0a9qgjs 126 22 for for IN cord-281487-x0a9qgjs 126 23 surveillance surveillance NN cord-281487-x0a9qgjs 126 24 for for IN cord-281487-x0a9qgjs 126 25 cardiac cardiac JJ cord-281487-x0a9qgjs 126 26 allograft allograft NN cord-281487-x0a9qgjs 126 27 rejection rejection NN cord-281487-x0a9qgjs 126 28 to to TO cord-281487-x0a9qgjs 126 29 reduce reduce VB cord-281487-x0a9qgjs 126 30 need need NN cord-281487-x0a9qgjs 126 31 for for IN cord-281487-x0a9qgjs 126 32 invasive invasive JJ cord-281487-x0a9qgjs 126 33 biopsies biopsy NNS cord-281487-x0a9qgjs 126 34 [ [ -LRB- cord-281487-x0a9qgjs 126 35 54 54 CD cord-281487-x0a9qgjs 126 36 ] ] -RRB- cord-281487-x0a9qgjs 126 37 . . . cord-281487-x0a9qgjs 127 1 The the DT cord-281487-x0a9qgjs 127 2 emotional emotional JJ cord-281487-x0a9qgjs 127 3 toll toll NN cord-281487-x0a9qgjs 127 4 of of IN cord-281487-x0a9qgjs 127 5 the the DT cord-281487-x0a9qgjs 127 6 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 127 7 pandemic pandemic NN cord-281487-x0a9qgjs 127 8 should should MD cord-281487-x0a9qgjs 127 9 be be VB cord-281487-x0a9qgjs 127 10 recognized recognize VBN cord-281487-x0a9qgjs 127 11 and and CC cord-281487-x0a9qgjs 127 12 addressed address VBN cord-281487-x0a9qgjs 127 13 with with IN cord-281487-x0a9qgjs 127 14 patients patient NNS cord-281487-x0a9qgjs 127 15 . . . cord-281487-x0a9qgjs 128 1 Fear fear NN cord-281487-x0a9qgjs 128 2 of of IN cord-281487-x0a9qgjs 128 3 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 128 4 and and CC cord-281487-x0a9qgjs 128 5 health health NN cord-281487-x0a9qgjs 128 6 recommendations recommendation NNS cord-281487-x0a9qgjs 128 7 to to IN cord-281487-x0a9qgjs 128 8 transplant transplant NN cord-281487-x0a9qgjs 128 9 recipients recipient NNS cord-281487-x0a9qgjs 128 10 to to TO cord-281487-x0a9qgjs 128 11 shelter shelter VB cord-281487-x0a9qgjs 128 12 in in IN cord-281487-x0a9qgjs 128 13 place place NN cord-281487-x0a9qgjs 128 14 when when WRB cord-281487-x0a9qgjs 128 15 there there EX cord-281487-x0a9qgjs 128 16 is be VBZ cord-281487-x0a9qgjs 128 17 significant significant JJ cord-281487-x0a9qgjs 128 18 community community NN cord-281487-x0a9qgjs 128 19 spread spread VBN cord-281487-x0a9qgjs 128 20 may may MD cord-281487-x0a9qgjs 128 21 worsen worsen VB cord-281487-x0a9qgjs 128 22 anxiety anxiety NN cord-281487-x0a9qgjs 128 23 , , , cord-281487-x0a9qgjs 128 24 and/or and/or CC cord-281487-x0a9qgjs 128 25 cause cause VB cord-281487-x0a9qgjs 128 26 patients patient NNS cord-281487-x0a9qgjs 128 27 to to TO cord-281487-x0a9qgjs 128 28 defer defer VB cord-281487-x0a9qgjs 128 29 essential essential JJ cord-281487-x0a9qgjs 128 30 health health NN cord-281487-x0a9qgjs 128 31 care care NN cord-281487-x0a9qgjs 128 32 . . . cord-281487-x0a9qgjs 129 1 The the DT cord-281487-x0a9qgjs 129 2 emotional emotional JJ cord-281487-x0a9qgjs 129 3 toll toll NN cord-281487-x0a9qgjs 129 4 of of IN cord-281487-x0a9qgjs 129 5 social social JJ cord-281487-x0a9qgjs 129 6 isolation isolation NN cord-281487-x0a9qgjs 129 7 may may MD cord-281487-x0a9qgjs 129 8 lead lead VB cord-281487-x0a9qgjs 129 9 transplant transplant NN cord-281487-x0a9qgjs 129 10 recipients recipient NNS cord-281487-x0a9qgjs 129 11 to to TO cord-281487-x0a9qgjs 129 12 engage engage VB cord-281487-x0a9qgjs 129 13 in in IN cord-281487-x0a9qgjs 129 14 behaviors behavior NNS cord-281487-x0a9qgjs 129 15 that that WDT cord-281487-x0a9qgjs 129 16 increase increase VBP cord-281487-x0a9qgjs 129 17 their -PRON- PRP$ cord-281487-x0a9qgjs 129 18 risk risk NN cord-281487-x0a9qgjs 129 19 of of IN cord-281487-x0a9qgjs 129 20 exposure exposure NN cord-281487-x0a9qgjs 129 21 to to IN cord-281487-x0a9qgjs 129 22 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 129 23 . . . cord-281487-x0a9qgjs 130 1 Thus thus RB cord-281487-x0a9qgjs 130 2 , , , cord-281487-x0a9qgjs 130 3 the the DT cord-281487-x0a9qgjs 130 4 transplant transplant NN cord-281487-x0a9qgjs 130 5 team team NN cord-281487-x0a9qgjs 130 6 should should MD cord-281487-x0a9qgjs 130 7 assess assess VB cord-281487-x0a9qgjs 130 8 mental mental JJ cord-281487-x0a9qgjs 130 9 health health NN cord-281487-x0a9qgjs 130 10 during during IN cord-281487-x0a9qgjs 130 11 their -PRON- PRP$ cord-281487-x0a9qgjs 130 12 patient patient JJ cord-281487-x0a9qgjs 130 13 encounters encounter NNS cord-281487-x0a9qgjs 130 14 and and CC cord-281487-x0a9qgjs 130 15 provide provide VB cord-281487-x0a9qgjs 130 16 referrals referral NNS cord-281487-x0a9qgjs 130 17 or or CC cord-281487-x0a9qgjs 130 18 interventions intervention NNS cord-281487-x0a9qgjs 130 19 as as IN cord-281487-x0a9qgjs 130 20 appropriate appropriate JJ cord-281487-x0a9qgjs 130 21 during during IN cord-281487-x0a9qgjs 130 22 this this DT cord-281487-x0a9qgjs 130 23 unprecedented unprecedented JJ cord-281487-x0a9qgjs 130 24 challenge challenge NN cord-281487-x0a9qgjs 130 25 . . . cord-281487-x0a9qgjs 131 1 In in IN cord-281487-x0a9qgjs 131 2 transplant transplant NN cord-281487-x0a9qgjs 131 3 recipients recipient NNS cord-281487-x0a9qgjs 131 4 with with IN cord-281487-x0a9qgjs 131 5 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 131 6 , , , cord-281487-x0a9qgjs 131 7 depression depression NN cord-281487-x0a9qgjs 131 8 , , , cord-281487-x0a9qgjs 131 9 anxiety anxiety NN cord-281487-x0a9qgjs 131 10 , , , cord-281487-x0a9qgjs 131 11 and and CC cord-281487-x0a9qgjs 131 12 sleep sleep NN cord-281487-x0a9qgjs 131 13 disturbances disturbance NNS cord-281487-x0a9qgjs 131 14 associated associate VBN cord-281487-x0a9qgjs 131 15 with with IN cord-281487-x0a9qgjs 131 16 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 131 17 can can MD cord-281487-x0a9qgjs 131 18 worsen worsen VB cord-281487-x0a9qgjs 131 19 non non JJ cord-281487-x0a9qgjs 131 20 - - JJ cord-281487-x0a9qgjs 131 21 adherence adherence JJ cord-281487-x0a9qgjs 131 22 to to IN cord-281487-x0a9qgjs 131 23 immunosuppressive immunosuppressive JJ cord-281487-x0a9qgjs 131 24 therapy therapy NN cord-281487-x0a9qgjs 131 25 and and CC cord-281487-x0a9qgjs 131 26 increase increase VB cord-281487-x0a9qgjs 131 27 the the DT cord-281487-x0a9qgjs 131 28 risk risk NN cord-281487-x0a9qgjs 131 29 of of IN cord-281487-x0a9qgjs 131 30 allograft allograft NN cord-281487-x0a9qgjs 131 31 rejection rejection NN cord-281487-x0a9qgjs 131 32 [ [ -LRB- cord-281487-x0a9qgjs 131 33 58 58 CD cord-281487-x0a9qgjs 131 34 ] ] -RRB- cord-281487-x0a9qgjs 131 35 . . . cord-281487-x0a9qgjs 132 1 Melatonin melatonin NN cord-281487-x0a9qgjs 132 2 is be VBZ cord-281487-x0a9qgjs 132 3 an an DT cord-281487-x0a9qgjs 132 4 effective effective JJ cord-281487-x0a9qgjs 132 5 drug drug NN cord-281487-x0a9qgjs 132 6 for for IN cord-281487-x0a9qgjs 132 7 anxiety anxiety NN cord-281487-x0a9qgjs 132 8 and and CC cord-281487-x0a9qgjs 132 9 sleep sleep NN cord-281487-x0a9qgjs 132 10 disturbances disturbance NNS cord-281487-x0a9qgjs 132 11 , , , cord-281487-x0a9qgjs 132 12 which which WDT cord-281487-x0a9qgjs 132 13 might may MD cord-281487-x0a9qgjs 132 14 also also RB cord-281487-x0a9qgjs 132 15 be be VB cord-281487-x0a9qgjs 132 16 beneficial beneficial JJ cord-281487-x0a9qgjs 132 17 for for IN cord-281487-x0a9qgjs 132 18 clinical clinical JJ cord-281487-x0a9qgjs 132 19 outcomes outcome NNS cord-281487-x0a9qgjs 132 20 of of IN cord-281487-x0a9qgjs 132 21 patients patient NNS cord-281487-x0a9qgjs 132 22 with with IN cord-281487-x0a9qgjs 132 23 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 132 24 due due IN cord-281487-x0a9qgjs 132 25 to to IN cord-281487-x0a9qgjs 132 26 its -PRON- PRP$ cord-281487-x0a9qgjs 132 27 anti anti JJ cord-281487-x0a9qgjs 132 28 - - JJ cord-281487-x0a9qgjs 132 29 inflammatory inflammatory JJ cord-281487-x0a9qgjs 132 30 and and CC cord-281487-x0a9qgjs 132 31 anti anti JJ cord-281487-x0a9qgjs 132 32 - - JJ cord-281487-x0a9qgjs 132 33 oxidant oxidant JJ cord-281487-x0a9qgjs 132 34 properties property NNS cord-281487-x0a9qgjs 132 35 [ [ -LRB- cord-281487-x0a9qgjs 132 36 59 59 CD cord-281487-x0a9qgjs 132 37 , , , cord-281487-x0a9qgjs 132 38 60 60 CD cord-281487-x0a9qgjs 132 39 ] ] -RRB- cord-281487-x0a9qgjs 132 40 . . . cord-281487-x0a9qgjs 133 1 Transplant transplant NN cord-281487-x0a9qgjs 133 2 recipients recipient NNS cord-281487-x0a9qgjs 133 3 with with IN cord-281487-x0a9qgjs 133 4 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 133 5 can can MD cord-281487-x0a9qgjs 133 6 progress progress VB cord-281487-x0a9qgjs 133 7 rapidly rapidly RB cord-281487-x0a9qgjs 133 8 and and CC cord-281487-x0a9qgjs 133 9 seriously seriously RB cord-281487-x0a9qgjs 133 10 . . . cord-281487-x0a9qgjs 134 1 They -PRON- PRP cord-281487-x0a9qgjs 134 2 should should MD cord-281487-x0a9qgjs 134 3 be be VB cord-281487-x0a9qgjs 134 4 monitored monitor VBN cord-281487-x0a9qgjs 134 5 and and CC cord-281487-x0a9qgjs 134 6 managed manage VBN cord-281487-x0a9qgjs 134 7 through through IN cord-281487-x0a9qgjs 134 8 frequent frequent JJ cord-281487-x0a9qgjs 134 9 communication communication NN cord-281487-x0a9qgjs 134 10 between between IN cord-281487-x0a9qgjs 134 11 the the DT cord-281487-x0a9qgjs 134 12 transplant transplant NN cord-281487-x0a9qgjs 134 13 team team NN cord-281487-x0a9qgjs 134 14 and and CC cord-281487-x0a9qgjs 134 15 patients patient NNS cord-281487-x0a9qgjs 134 16 . . . cord-281487-x0a9qgjs 135 1 Figure figure NN cord-281487-x0a9qgjs 135 2 1 1 CD cord-281487-x0a9qgjs 135 3 shows show VBZ cord-281487-x0a9qgjs 135 4 a a DT cord-281487-x0a9qgjs 135 5 model model NN cord-281487-x0a9qgjs 135 6 for for IN cord-281487-x0a9qgjs 135 7 the the DT cord-281487-x0a9qgjs 135 8 management management NN cord-281487-x0a9qgjs 135 9 of of IN cord-281487-x0a9qgjs 135 10 solid solid JJ cord-281487-x0a9qgjs 135 11 organ organ NN cord-281487-x0a9qgjs 135 12 transplant transplant NN cord-281487-x0a9qgjs 135 13 recipients recipient NNS cord-281487-x0a9qgjs 135 14 during during IN cord-281487-x0a9qgjs 135 15 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 135 16 pandemic pandemic NN cord-281487-x0a9qgjs 135 17 , , , cord-281487-x0a9qgjs 135 18 based base VBN cord-281487-x0a9qgjs 135 19 on on IN cord-281487-x0a9qgjs 135 20 recommendations recommendation NNS cord-281487-x0a9qgjs 135 21 of of IN cord-281487-x0a9qgjs 135 22 the the DT cord-281487-x0a9qgjs 135 23 Centers Centers NNPS cord-281487-x0a9qgjs 135 24 for for IN cord-281487-x0a9qgjs 135 25 Disease Disease NNP cord-281487-x0a9qgjs 135 26 Control Control NNP cord-281487-x0a9qgjs 135 27 and and CC cord-281487-x0a9qgjs 135 28 Prevention Prevention NNP cord-281487-x0a9qgjs 135 29 ( ( -LRB- cord-281487-x0a9qgjs 135 30 CDC CDC NNP cord-281487-x0a9qgjs 135 31 ) ) -RRB- cord-281487-x0a9qgjs 135 32 and and CC cord-281487-x0a9qgjs 135 33 the the DT cord-281487-x0a9qgjs 135 34 American American NNP cord-281487-x0a9qgjs 135 35 Society Society NNP cord-281487-x0a9qgjs 135 36 of of IN cord-281487-x0a9qgjs 135 37 Transplantation Transplantation NNP cord-281487-x0a9qgjs 135 38 ( ( -LRB- cord-281487-x0a9qgjs 135 39 AST ast NN cord-281487-x0a9qgjs 135 40 ) ) -RRB- cord-281487-x0a9qgjs 136 1 [ [ -LRB- cord-281487-x0a9qgjs 136 2 52 52 CD cord-281487-x0a9qgjs 136 3 , , , cord-281487-x0a9qgjs 136 4 61 61 CD cord-281487-x0a9qgjs 136 5 ] ] -RRB- cord-281487-x0a9qgjs 136 6 . . . cord-281487-x0a9qgjs 137 1 Transplant transplant NN cord-281487-x0a9qgjs 137 2 recipients recipient NNS cord-281487-x0a9qgjs 137 3 with with IN cord-281487-x0a9qgjs 137 4 direct direct JJ cord-281487-x0a9qgjs 137 5 contact contact NN cord-281487-x0a9qgjs 137 6 ( ( -LRB- cord-281487-x0a9qgjs 137 7 < < NNP cord-281487-x0a9qgjs 137 8 6 6 CD cord-281487-x0a9qgjs 137 9 ft ft NN cord-281487-x0a9qgjs 137 10 for for IN cord-281487-x0a9qgjs 137 11 ≥ ≥ CD cord-281487-x0a9qgjs 137 12 15 15 CD cord-281487-x0a9qgjs 137 13 min min NNP cord-281487-x0a9qgjs 137 14 ) ) -RRB- cord-281487-x0a9qgjs 137 15 with with IN cord-281487-x0a9qgjs 137 16 a a DT cord-281487-x0a9qgjs 137 17 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 137 18 infected infected JJ cord-281487-x0a9qgjs 137 19 individual individual NN cord-281487-x0a9qgjs 137 20 should should MD cord-281487-x0a9qgjs 137 21 be be VB cord-281487-x0a9qgjs 137 22 quarantined quarantine VBN cord-281487-x0a9qgjs 137 23 for for IN cord-281487-x0a9qgjs 137 24 14 14 CD cord-281487-x0a9qgjs 137 25 days day NNS cord-281487-x0a9qgjs 137 26 and and CC cord-281487-x0a9qgjs 137 27 consider consider VB cord-281487-x0a9qgjs 137 28 testing test VBG cord-281487-x0a9qgjs 137 29 for for IN cord-281487-x0a9qgjs 137 30 SARS SARS NNP cord-281487-x0a9qgjs 137 31 - - HYPH cord-281487-x0a9qgjs 137 32 CoV-2 CoV-2 NNP cord-281487-x0a9qgjs 137 33 after after IN cord-281487-x0a9qgjs 137 34 exposure exposure NN cord-281487-x0a9qgjs 137 35 or or CC cord-281487-x0a9qgjs 137 36 if if IN cord-281487-x0a9qgjs 137 37 they -PRON- PRP cord-281487-x0a9qgjs 137 38 develop develop VBP cord-281487-x0a9qgjs 137 39 symptoms symptom NNS cord-281487-x0a9qgjs 137 40 [ [ -LRB- cord-281487-x0a9qgjs 137 41 49 49 CD cord-281487-x0a9qgjs 137 42 , , , cord-281487-x0a9qgjs 137 43 52 52 CD cord-281487-x0a9qgjs 137 44 ] ] -RRB- cord-281487-x0a9qgjs 137 45 . . . cord-281487-x0a9qgjs 138 1 Patients patient NNS cord-281487-x0a9qgjs 138 2 with with IN cord-281487-x0a9qgjs 138 3 confirmed confirm VBN cord-281487-x0a9qgjs 138 4 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 138 5 should should MD cord-281487-x0a9qgjs 138 6 check check VB cord-281487-x0a9qgjs 138 7 their -PRON- PRP$ cord-281487-x0a9qgjs 138 8 temperature temperature NN cord-281487-x0a9qgjs 138 9 and and CC cord-281487-x0a9qgjs 138 10 respiratory respiratory JJ cord-281487-x0a9qgjs 138 11 rate rate NN cord-281487-x0a9qgjs 138 12 ( ( -LRB- cord-281487-x0a9qgjs 138 13 RR RR NNP cord-281487-x0a9qgjs 138 14 ) ) -RRB- cord-281487-x0a9qgjs 138 15 , , , cord-281487-x0a9qgjs 138 16 oxygen oxygen NN cord-281487-x0a9qgjs 138 17 saturation saturation NN cord-281487-x0a9qgjs 138 18 , , , cord-281487-x0a9qgjs 138 19 and and CC cord-281487-x0a9qgjs 138 20 symptoms symptom NNS cord-281487-x0a9qgjs 138 21 . . . cord-281487-x0a9qgjs 139 1 Transplant transplant NN cord-281487-x0a9qgjs 139 2 centers center NNS cord-281487-x0a9qgjs 139 3 should should MD cord-281487-x0a9qgjs 139 4 consider consider VB cord-281487-x0a9qgjs 139 5 assistance assistance NN cord-281487-x0a9qgjs 139 6 for for IN cord-281487-x0a9qgjs 139 7 pulse pulse NN cord-281487-x0a9qgjs 139 8 oximeters oximeter NNS cord-281487-x0a9qgjs 139 9 if if IN cord-281487-x0a9qgjs 139 10 patients patient NNS cord-281487-x0a9qgjs 139 11 experience experience VBP cord-281487-x0a9qgjs 139 12 hardship hardship NN cord-281487-x0a9qgjs 139 13 in in IN cord-281487-x0a9qgjs 139 14 obtaining obtain VBG cord-281487-x0a9qgjs 139 15 these these DT cord-281487-x0a9qgjs 139 16 devices device NNS cord-281487-x0a9qgjs 139 17 . . . cord-281487-x0a9qgjs 140 1 If if IN cord-281487-x0a9qgjs 140 2 they -PRON- PRP cord-281487-x0a9qgjs 140 3 have have VBP cord-281487-x0a9qgjs 140 4 dyspnea dyspnea NN cord-281487-x0a9qgjs 140 5 or or CC cord-281487-x0a9qgjs 140 6 RR rr NN cord-281487-x0a9qgjs 140 7 ≥ ≥ CD cord-281487-x0a9qgjs 140 8 24 24 CD cord-281487-x0a9qgjs 140 9 per per IN cord-281487-x0a9qgjs 140 10 minute minute NN cord-281487-x0a9qgjs 140 11 , , , cord-281487-x0a9qgjs 140 12 oxygen oxygen NN cord-281487-x0a9qgjs 140 13 saturation saturation NN cord-281487-x0a9qgjs 141 1 < < NNP cord-281487-x0a9qgjs 141 2 94 94 CD cord-281487-x0a9qgjs 141 3 % % NN cord-281487-x0a9qgjs 141 4 , , , cord-281487-x0a9qgjs 141 5 persistent persistent JJ cord-281487-x0a9qgjs 141 6 or or CC cord-281487-x0a9qgjs 141 7 high high JJ cord-281487-x0a9qgjs 141 8 fever fever NN cord-281487-x0a9qgjs 141 9 , , , cord-281487-x0a9qgjs 141 10 difficulty difficulty NN cord-281487-x0a9qgjs 141 11 eating eat VBG cord-281487-x0a9qgjs 141 12 foods food NNS cord-281487-x0a9qgjs 141 13 with with IN cord-281487-x0a9qgjs 141 14 predominant predominant JJ cord-281487-x0a9qgjs 141 15 gastrointestinal gastrointestinal JJ cord-281487-x0a9qgjs 141 16 symptoms symptom NNS cord-281487-x0a9qgjs 141 17 , , , cord-281487-x0a9qgjs 141 18 low low JJ cord-281487-x0a9qgjs 141 19 urine urine NN cord-281487-x0a9qgjs 141 20 volume volume NN cord-281487-x0a9qgjs 141 21 ( ( -LRB- cord-281487-x0a9qgjs 141 22 < < NN cord-281487-x0a9qgjs 141 23 400 400 CD cord-281487-x0a9qgjs 141 24 mL ml NN cord-281487-x0a9qgjs 141 25 per per IN cord-281487-x0a9qgjs 141 26 day day NN cord-281487-x0a9qgjs 141 27 ) ) -RRB- cord-281487-x0a9qgjs 141 28 , , , cord-281487-x0a9qgjs 141 29 or or CC cord-281487-x0a9qgjs 141 30 worsening worsening NN cord-281487-x0a9qgjs 141 31 of of IN cord-281487-x0a9qgjs 141 32 general general JJ cord-281487-x0a9qgjs 141 33 conditions condition NNS cord-281487-x0a9qgjs 141 34 , , , cord-281487-x0a9qgjs 141 35 they -PRON- PRP cord-281487-x0a9qgjs 141 36 should should MD cord-281487-x0a9qgjs 141 37 plan plan VB cord-281487-x0a9qgjs 141 38 for for IN cord-281487-x0a9qgjs 141 39 hospitalization hospitalization NN cord-281487-x0a9qgjs 142 1 ( ( -LRB- cord-281487-x0a9qgjs 142 2 Fig Fig NNP cord-281487-x0a9qgjs 142 3 . . . cord-281487-x0a9qgjs 142 4 1 1 CD cord-281487-x0a9qgjs 142 5 ) ) -RRB- cord-281487-x0a9qgjs 142 6 [ [ -LRB- cord-281487-x0a9qgjs 142 7 52 52 CD cord-281487-x0a9qgjs 142 8 , , , cord-281487-x0a9qgjs 142 9 54 54 CD cord-281487-x0a9qgjs 142 10 ] ] -RRB- cord-281487-x0a9qgjs 142 11 . . . cord-281487-x0a9qgjs 143 1 The the DT cord-281487-x0a9qgjs 143 2 determination determination NN cord-281487-x0a9qgjs 143 3 of of IN cord-281487-x0a9qgjs 143 4 when when WRB cord-281487-x0a9qgjs 143 5 a a DT cord-281487-x0a9qgjs 143 6 transplant transplant NN cord-281487-x0a9qgjs 143 7 recipient recipient NN cord-281487-x0a9qgjs 143 8 is be VBZ cord-281487-x0a9qgjs 143 9 no no DT cord-281487-x0a9qgjs 143 10 longer long RBR cord-281487-x0a9qgjs 143 11 infectious infectious JJ cord-281487-x0a9qgjs 143 12 is be VBZ cord-281487-x0a9qgjs 143 13 evolving evolve VBG cord-281487-x0a9qgjs 143 14 . . . cord-281487-x0a9qgjs 144 1 Immunocompromised immunocompromise VBN cord-281487-x0a9qgjs 144 2 patients patient NNS cord-281487-x0a9qgjs 144 3 may may MD cord-281487-x0a9qgjs 144 4 have have VB cord-281487-x0a9qgjs 144 5 prolonged prolong VBN cord-281487-x0a9qgjs 144 6 viral viral JJ cord-281487-x0a9qgjs 144 7 shedding shedding NN cord-281487-x0a9qgjs 144 8 , , , cord-281487-x0a9qgjs 144 9 and and CC cord-281487-x0a9qgjs 144 10 further further JJ cord-281487-x0a9qgjs 144 11 research research NN cord-281487-x0a9qgjs 144 12 is be VBZ cord-281487-x0a9qgjs 144 13 needed need VBN cord-281487-x0a9qgjs 144 14 to to TO cord-281487-x0a9qgjs 144 15 determine determine VB cord-281487-x0a9qgjs 144 16 the the DT cord-281487-x0a9qgjs 144 17 timeframe timeframe NN cord-281487-x0a9qgjs 144 18 of of IN cord-281487-x0a9qgjs 144 19 infectivity infectivity NN cord-281487-x0a9qgjs 144 20 in in IN cord-281487-x0a9qgjs 144 21 this this DT cord-281487-x0a9qgjs 144 22 population population NN cord-281487-x0a9qgjs 144 23 [ [ -LRB- cord-281487-x0a9qgjs 144 24 62 62 CD cord-281487-x0a9qgjs 144 25 , , , cord-281487-x0a9qgjs 144 26 63 63 CD cord-281487-x0a9qgjs 144 27 ] ] -RRB- cord-281487-x0a9qgjs 144 28 . . . cord-281487-x0a9qgjs 145 1 The the DT cord-281487-x0a9qgjs 145 2 AST AST NNP cord-281487-x0a9qgjs 145 3 recommends recommend VBZ cord-281487-x0a9qgjs 145 4 a a DT cord-281487-x0a9qgjs 145 5 28-day 28-day CD cord-281487-x0a9qgjs 145 6 time time NN cord-281487-x0a9qgjs 145 7 - - HYPH cord-281487-x0a9qgjs 145 8 frame frame NN cord-281487-x0a9qgjs 145 9 because because IN cord-281487-x0a9qgjs 145 10 the the DT cord-281487-x0a9qgjs 145 11 shedding shedding NN cord-281487-x0a9qgjs 145 12 of of IN cord-281487-x0a9qgjs 145 13 the the DT cord-281487-x0a9qgjs 145 14 virus virus NN cord-281487-x0a9qgjs 145 15 can can MD cord-281487-x0a9qgjs 145 16 be be VB cord-281487-x0a9qgjs 145 17 prolonged prolong VBN cord-281487-x0a9qgjs 145 18 in in IN cord-281487-x0a9qgjs 145 19 transplant transplant NN cord-281487-x0a9qgjs 145 20 recipients recipient NNS cord-281487-x0a9qgjs 145 21 , , , cord-281487-x0a9qgjs 145 22 although although IN cord-281487-x0a9qgjs 145 23 infectivity infectivity NN cord-281487-x0a9qgjs 145 24 is be VBZ cord-281487-x0a9qgjs 145 25 unclear unclear JJ cord-281487-x0a9qgjs 145 26 [ [ -LRB- cord-281487-x0a9qgjs 145 27 61 61 CD cord-281487-x0a9qgjs 145 28 ] ] -RRB- cord-281487-x0a9qgjs 145 29 . . . cord-281487-x0a9qgjs 146 1 This this DT cord-281487-x0a9qgjs 146 2 is be VBZ cord-281487-x0a9qgjs 146 3 different different JJ cord-281487-x0a9qgjs 146 4 from from IN cord-281487-x0a9qgjs 146 5 recommendations recommendation NNS cord-281487-x0a9qgjs 146 6 for for IN cord-281487-x0a9qgjs 146 7 immunocompetent immunocompetent JJ cord-281487-x0a9qgjs 146 8 hosts host NNS cord-281487-x0a9qgjs 146 9 and and CC cord-281487-x0a9qgjs 146 10 should should MD cord-281487-x0a9qgjs 146 11 be be VB cord-281487-x0a9qgjs 146 12 communicated communicate VBN cord-281487-x0a9qgjs 146 13 to to IN cord-281487-x0a9qgjs 146 14 health health NN cord-281487-x0a9qgjs 146 15 care care NN cord-281487-x0a9qgjs 146 16 providers provider NNS cord-281487-x0a9qgjs 146 17 and and CC cord-281487-x0a9qgjs 146 18 COVID-19 covid-19 VB cord-281487-x0a9qgjs 146 19 infected infected JJ cord-281487-x0a9qgjs 146 20 transplant transplant NN cord-281487-x0a9qgjs 146 21 recipients recipient NNS cord-281487-x0a9qgjs 146 22 . . . cord-281487-x0a9qgjs 147 1 Alternatively alternatively RB cord-281487-x0a9qgjs 147 2 , , , cord-281487-x0a9qgjs 147 3 a a DT cord-281487-x0a9qgjs 147 4 test test NN cord-281487-x0a9qgjs 147 5 - - HYPH cord-281487-x0a9qgjs 147 6 based base VBN cord-281487-x0a9qgjs 147 7 strategy strategy NN cord-281487-x0a9qgjs 147 8 has have VBZ cord-281487-x0a9qgjs 147 9 also also RB cord-281487-x0a9qgjs 147 10 been be VBN cord-281487-x0a9qgjs 147 11 used use VBN cord-281487-x0a9qgjs 147 12 with with IN cord-281487-x0a9qgjs 147 13 the the DT cord-281487-x0a9qgjs 147 14 use use NN cord-281487-x0a9qgjs 147 15 of of IN cord-281487-x0a9qgjs 147 16 negative negative JJ cord-281487-x0a9qgjs 147 17 results result NNS cord-281487-x0a9qgjs 147 18 of of IN cord-281487-x0a9qgjs 147 19 RNA RNA NNP cord-281487-x0a9qgjs 147 20 PCR PCR NNP cord-281487-x0a9qgjs 147 21 tests test NNS cord-281487-x0a9qgjs 147 22 from from IN cord-281487-x0a9qgjs 147 23 at at RB cord-281487-x0a9qgjs 147 24 least least RBS cord-281487-x0a9qgjs 147 25 two two CD cord-281487-x0a9qgjs 147 26 consecutive consecutive JJ cord-281487-x0a9qgjs 147 27 respiratory respiratory JJ cord-281487-x0a9qgjs 147 28 specimens specimen NNS cord-281487-x0a9qgjs 147 29 ≥ ≥ CD cord-281487-x0a9qgjs 147 30 24 24 CD cord-281487-x0a9qgjs 147 31 h h NN cord-281487-x0a9qgjs 147 32 apart apart RB cord-281487-x0a9qgjs 147 33 as as RB cord-281487-x0a9qgjs 147 34 well well RB cord-281487-x0a9qgjs 147 35 as as IN cord-281487-x0a9qgjs 147 36 recovery recovery NN cord-281487-x0a9qgjs 147 37 of of IN cord-281487-x0a9qgjs 147 38 symptoms symptom NNS cord-281487-x0a9qgjs 147 39 . . . cord-281487-x0a9qgjs 148 1 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 148 2 progresses progress VBZ cord-281487-x0a9qgjs 148 3 through through IN cord-281487-x0a9qgjs 148 4 syndrome syndrome NN cord-281487-x0a9qgjs 148 5 phases phase NNS cord-281487-x0a9qgjs 148 6 that that WDT cord-281487-x0a9qgjs 148 7 include include VBP cord-281487-x0a9qgjs 148 8 : : : cord-281487-x0a9qgjs 148 9 the the DT cord-281487-x0a9qgjs 148 10 early early JJ cord-281487-x0a9qgjs 148 11 infection infection NN cord-281487-x0a9qgjs 148 12 phase phase NN cord-281487-x0a9qgjs 148 13 , , , cord-281487-x0a9qgjs 148 14 the the DT cord-281487-x0a9qgjs 148 15 pulmonary pulmonary JJ cord-281487-x0a9qgjs 148 16 phase phase NN cord-281487-x0a9qgjs 148 17 , , , cord-281487-x0a9qgjs 148 18 and and CC cord-281487-x0a9qgjs 148 19 the the DT cord-281487-x0a9qgjs 148 20 hyperinflammation hyperinflammation NN cord-281487-x0a9qgjs 148 21 phase phase NN cord-281487-x0a9qgjs 148 22 [ [ -LRB- cord-281487-x0a9qgjs 148 23 64 64 CD cord-281487-x0a9qgjs 148 24 ] ] -RRB- cord-281487-x0a9qgjs 148 25 . . . cord-281487-x0a9qgjs 149 1 The the DT cord-281487-x0a9qgjs 149 2 early early JJ cord-281487-x0a9qgjs 149 3 infection infection NN cord-281487-x0a9qgjs 149 4 phase phase NN cord-281487-x0a9qgjs 149 5 is be VBZ cord-281487-x0a9qgjs 149 6 triggered trigger VBN cord-281487-x0a9qgjs 149 7 by by IN cord-281487-x0a9qgjs 149 8 the the DT cord-281487-x0a9qgjs 149 9 virus virus NN cord-281487-x0a9qgjs 149 10 itself -PRON- PRP cord-281487-x0a9qgjs 149 11 and and CC cord-281487-x0a9qgjs 149 12 the the DT cord-281487-x0a9qgjs 149 13 hyperinflammation hyperinflammation NN cord-281487-x0a9qgjs 149 14 phase phase NN cord-281487-x0a9qgjs 149 15 is be VBZ cord-281487-x0a9qgjs 149 16 developed develop VBN cord-281487-x0a9qgjs 149 17 by by IN cord-281487-x0a9qgjs 149 18 the the DT cord-281487-x0a9qgjs 149 19 host host NN cord-281487-x0a9qgjs 149 20 response response NN cord-281487-x0a9qgjs 149 21 . . . cord-281487-x0a9qgjs 150 1 At at IN cord-281487-x0a9qgjs 150 2 the the DT cord-281487-x0a9qgjs 150 3 initial initial JJ cord-281487-x0a9qgjs 150 4 stage stage NN cord-281487-x0a9qgjs 150 5 or or CC cord-281487-x0a9qgjs 150 6 infection infection NN cord-281487-x0a9qgjs 150 7 , , , cord-281487-x0a9qgjs 150 8 most most JJS cord-281487-x0a9qgjs 150 9 patients patient NNS cord-281487-x0a9qgjs 150 10 have have VBP cord-281487-x0a9qgjs 150 11 mild mild JJ cord-281487-x0a9qgjs 150 12 , , , cord-281487-x0a9qgjs 150 13 non non JJ cord-281487-x0a9qgjs 150 14 - - JJ cord-281487-x0a9qgjs 150 15 specific specific JJ cord-281487-x0a9qgjs 150 16 symptoms symptom NNS cord-281487-x0a9qgjs 150 17 . . . cord-281487-x0a9qgjs 151 1 Because because IN cord-281487-x0a9qgjs 151 2 SARS SARS NNP cord-281487-x0a9qgjs 151 3 - - HYPH cord-281487-x0a9qgjs 151 4 CoV-2 CoV-2 NNP cord-281487-x0a9qgjs 151 5 multiplies multiply VBZ cord-281487-x0a9qgjs 151 6 and and CC cord-281487-x0a9qgjs 151 7 establishes establish VBZ cord-281487-x0a9qgjs 151 8 residence residence NN cord-281487-x0a9qgjs 151 9 in in IN cord-281487-x0a9qgjs 151 10 the the DT cord-281487-x0a9qgjs 151 11 host host NN cord-281487-x0a9qgjs 151 12 during during IN cord-281487-x0a9qgjs 151 13 this this DT cord-281487-x0a9qgjs 151 14 period period NN cord-281487-x0a9qgjs 151 15 , , , cord-281487-x0a9qgjs 151 16 the the DT cord-281487-x0a9qgjs 151 17 reduction reduction NN cord-281487-x0a9qgjs 151 18 of of IN cord-281487-x0a9qgjs 151 19 immunosuppressive immunosuppressive JJ cord-281487-x0a9qgjs 151 20 agents agent NNS cord-281487-x0a9qgjs 151 21 should should MD cord-281487-x0a9qgjs 151 22 be be VB cord-281487-x0a9qgjs 151 23 considered consider VBN cord-281487-x0a9qgjs 151 24 to to TO cord-281487-x0a9qgjs 151 25 enhance enhance VB cord-281487-x0a9qgjs 151 26 viral viral JJ cord-281487-x0a9qgjs 151 27 clearance clearance NN cord-281487-x0a9qgjs 151 28 [ [ -LRB- cord-281487-x0a9qgjs 151 29 64 64 CD cord-281487-x0a9qgjs 151 30 ] ] -RRB- cord-281487-x0a9qgjs 151 31 . . . cord-281487-x0a9qgjs 152 1 At at IN cord-281487-x0a9qgjs 152 2 the the DT cord-281487-x0a9qgjs 152 3 JH JH NNP cord-281487-x0a9qgjs 152 4 - - HYPH cord-281487-x0a9qgjs 152 5 CTC CTC NNP cord-281487-x0a9qgjs 152 6 , , , cord-281487-x0a9qgjs 152 7 it -PRON- PRP cord-281487-x0a9qgjs 152 8 is be VBZ cord-281487-x0a9qgjs 152 9 recommended recommend VBN cord-281487-x0a9qgjs 152 10 that that IN cord-281487-x0a9qgjs 152 11 mycophenolate mycophenolate NNP cord-281487-x0a9qgjs 152 12 be be VB cord-281487-x0a9qgjs 152 13 preemptively preemptively RB cord-281487-x0a9qgjs 152 14 discontinued discontinue VBN cord-281487-x0a9qgjs 152 15 if if IN cord-281487-x0a9qgjs 152 16 the the DT cord-281487-x0a9qgjs 152 17 absolute absolute JJ cord-281487-x0a9qgjs 152 18 lymphocyte lymphocyte NN cord-281487-x0a9qgjs 152 19 count count NN cord-281487-x0a9qgjs 152 20 ( ( -LRB- cord-281487-x0a9qgjs 152 21 ALC ALC NNP cord-281487-x0a9qgjs 152 22 ) ) -RRB- cord-281487-x0a9qgjs 152 23 were be VBD cord-281487-x0a9qgjs 152 24 < < XX cord-281487-x0a9qgjs 152 25 700 700 CD cord-281487-x0a9qgjs 152 26 cells cell NNS cord-281487-x0a9qgjs 152 27 / / SYM cord-281487-x0a9qgjs 152 28 mL ml NN cord-281487-x0a9qgjs 152 29 and and CC cord-281487-x0a9qgjs 152 30 reduced reduce VBN cord-281487-x0a9qgjs 152 31 if if IN cord-281487-x0a9qgjs 152 32 the the DT cord-281487-x0a9qgjs 152 33 ALC ALC NNP cord-281487-x0a9qgjs 152 34 was be VBD cord-281487-x0a9qgjs 152 35 700 700 CD cord-281487-x0a9qgjs 152 36 - - SYM cord-281487-x0a9qgjs 152 37 1000 1000 CD cord-281487-x0a9qgjs 152 38 cells cell NNS cord-281487-x0a9qgjs 152 39 / / SYM cord-281487-x0a9qgjs 152 40 mL. mL. NNS cord-281487-x0a9qgjs 153 1 Because because IN cord-281487-x0a9qgjs 153 2 calcineurin calcineurin NNP cord-281487-x0a9qgjs 153 3 inhibitors inhibitor NNS cord-281487-x0a9qgjs 153 4 ( ( -LRB- cord-281487-x0a9qgjs 153 5 CNIs CNIs NNP cord-281487-x0a9qgjs 153 6 ) ) -RRB- cord-281487-x0a9qgjs 153 7 block block NN cord-281487-x0a9qgjs 153 8 nuclear nuclear JJ cord-281487-x0a9qgjs 153 9 factor factor NN cord-281487-x0a9qgjs 153 10 of of IN cord-281487-x0a9qgjs 153 11 activated activate VBN cord-281487-x0a9qgjs 153 12 T T NNP cord-281487-x0a9qgjs 153 13 cells cell NNS cord-281487-x0a9qgjs 153 14 ( ( -LRB- cord-281487-x0a9qgjs 153 15 NFAT NFAT NNP cord-281487-x0a9qgjs 153 16 ) ) -RRB- cord-281487-x0a9qgjs 153 17 and and CC cord-281487-x0a9qgjs 153 18 thus thus RB cord-281487-x0a9qgjs 153 19 transcription transcription NN cord-281487-x0a9qgjs 153 20 of of IN cord-281487-x0a9qgjs 153 21 downstream downstream JJ cord-281487-x0a9qgjs 153 22 inflammatory inflammatory JJ cord-281487-x0a9qgjs 153 23 cytokines cytokine NNS cord-281487-x0a9qgjs 153 24 , , , cord-281487-x0a9qgjs 153 25 we -PRON- PRP cord-281487-x0a9qgjs 153 26 do do VBP cord-281487-x0a9qgjs 153 27 not not RB cord-281487-x0a9qgjs 153 28 recommend recommend VB cord-281487-x0a9qgjs 153 29 reducing reduce VBG cord-281487-x0a9qgjs 153 30 the the DT cord-281487-x0a9qgjs 153 31 CNIs cni NNS cord-281487-x0a9qgjs 153 32 and and CC cord-281487-x0a9qgjs 153 33 maintain maintain VB cord-281487-x0a9qgjs 153 34 tacrolimus tacrolimus NN cord-281487-x0a9qgjs 153 35 levels level NNS cord-281487-x0a9qgjs 153 36 between between IN cord-281487-x0a9qgjs 153 37 5 5 CD cord-281487-x0a9qgjs 153 38 and and CC cord-281487-x0a9qgjs 153 39 10 10 CD cord-281487-x0a9qgjs 153 40 ng ng NN cord-281487-x0a9qgjs 153 41 / / SYM cord-281487-x0a9qgjs 153 42 mL. mL. NNP cord-281487-x0a9qgjs 153 43 Clinical clinical JJ cord-281487-x0a9qgjs 153 44 trials trial NNS cord-281487-x0a9qgjs 153 45 of of IN cord-281487-x0a9qgjs 153 46 therapies therapy NNS cord-281487-x0a9qgjs 153 47 to to TO cord-281487-x0a9qgjs 153 48 enhance enhance VB cord-281487-x0a9qgjs 153 49 viral viral JJ cord-281487-x0a9qgjs 153 50 clearance clearance NN cord-281487-x0a9qgjs 153 51 , , , cord-281487-x0a9qgjs 153 52 such such JJ cord-281487-x0a9qgjs 153 53 convalescent convalescent JJ cord-281487-x0a9qgjs 153 54 plasma plasma NN cord-281487-x0a9qgjs 153 55 may may MD cord-281487-x0a9qgjs 153 56 be be VB cord-281487-x0a9qgjs 153 57 offered offer VBN cord-281487-x0a9qgjs 153 58 at at IN cord-281487-x0a9qgjs 153 59 this this DT cord-281487-x0a9qgjs 153 60 stage stage NN cord-281487-x0a9qgjs 153 61 . . . cord-281487-x0a9qgjs 154 1 In in IN cord-281487-x0a9qgjs 154 2 the the DT cord-281487-x0a9qgjs 154 3 second second JJ cord-281487-x0a9qgjs 154 4 stage stage NN cord-281487-x0a9qgjs 154 5 , , , cord-281487-x0a9qgjs 154 6 viral viral JJ cord-281487-x0a9qgjs 154 7 multiplication multiplication NN cord-281487-x0a9qgjs 154 8 and and CC cord-281487-x0a9qgjs 154 9 localized localized JJ cord-281487-x0a9qgjs 154 10 lung lung NN cord-281487-x0a9qgjs 154 11 inflammation inflammation NN cord-281487-x0a9qgjs 154 12 occur occur VBP cord-281487-x0a9qgjs 154 13 [ [ -LRB- cord-281487-x0a9qgjs 154 14 64 64 CD cord-281487-x0a9qgjs 154 15 ] ] -RRB- cord-281487-x0a9qgjs 154 16 . . . cord-281487-x0a9qgjs 155 1 Markers marker NNS cord-281487-x0a9qgjs 155 2 of of IN cord-281487-x0a9qgjs 155 3 systemic systemic JJ cord-281487-x0a9qgjs 155 4 inflammation inflammation NN cord-281487-x0a9qgjs 155 5 may may MD cord-281487-x0a9qgjs 155 6 be be VB cord-281487-x0a9qgjs 155 7 elevated elevate VBN cord-281487-x0a9qgjs 155 8 . . . cord-281487-x0a9qgjs 156 1 Anti anti JJ cord-281487-x0a9qgjs 156 2 - - JJ cord-281487-x0a9qgjs 156 3 viral viral JJ cord-281487-x0a9qgjs 156 4 therapies therapy NNS cord-281487-x0a9qgjs 156 5 , , , cord-281487-x0a9qgjs 156 6 as as IN cord-281487-x0a9qgjs 156 7 discussed discuss VBN cord-281487-x0a9qgjs 156 8 in in IN cord-281487-x0a9qgjs 156 9 a a DT cord-281487-x0a9qgjs 156 10 separate separate JJ cord-281487-x0a9qgjs 156 11 article article NN cord-281487-x0a9qgjs 156 12 of of IN cord-281487-x0a9qgjs 156 13 this this DT cord-281487-x0a9qgjs 156 14 issue issue NN cord-281487-x0a9qgjs 156 15 , , , cord-281487-x0a9qgjs 156 16 may may MD cord-281487-x0a9qgjs 156 17 be be VB cord-281487-x0a9qgjs 156 18 indicated indicate VBN cord-281487-x0a9qgjs 156 19 for for IN cord-281487-x0a9qgjs 156 20 patients patient NNS cord-281487-x0a9qgjs 156 21 with with IN cord-281487-x0a9qgjs 156 22 hypoxia hypoxia NN cord-281487-x0a9qgjs 156 23 , , , cord-281487-x0a9qgjs 156 24 and and CC cord-281487-x0a9qgjs 156 25 investigational investigational JJ cord-281487-x0a9qgjs 156 26 agents agent NNS cord-281487-x0a9qgjs 156 27 may may MD cord-281487-x0a9qgjs 156 28 be be VB cord-281487-x0a9qgjs 156 29 considered consider VBN cord-281487-x0a9qgjs 156 30 . . . cord-281487-x0a9qgjs 157 1 A a DT cord-281487-x0a9qgjs 157 2 minority minority NN cord-281487-x0a9qgjs 157 3 of of IN cord-281487-x0a9qgjs 157 4 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 157 5 patients patient NNS cord-281487-x0a9qgjs 157 6 progress progress VBP cord-281487-x0a9qgjs 157 7 into into IN cord-281487-x0a9qgjs 157 8 the the DT cord-281487-x0a9qgjs 157 9 hyperinflammation hyperinflammation NN cord-281487-x0a9qgjs 157 10 phase phase NN cord-281487-x0a9qgjs 157 11 . . . cord-281487-x0a9qgjs 158 1 In in IN cord-281487-x0a9qgjs 158 2 this this DT cord-281487-x0a9qgjs 158 3 stage stage NN cord-281487-x0a9qgjs 158 4 , , , cord-281487-x0a9qgjs 158 5 markers marker NNS cord-281487-x0a9qgjs 158 6 of of IN cord-281487-x0a9qgjs 158 7 systemic systemic JJ cord-281487-x0a9qgjs 158 8 inflammation inflammation NN cord-281487-x0a9qgjs 158 9 are be VBP cord-281487-x0a9qgjs 158 10 elevated elevated JJ cord-281487-x0a9qgjs 158 11 and and CC cord-281487-x0a9qgjs 158 12 systemic systemic JJ cord-281487-x0a9qgjs 158 13 organs organ NNS cord-281487-x0a9qgjs 158 14 would would MD cord-281487-x0a9qgjs 158 15 be be VB cord-281487-x0a9qgjs 158 16 involved involve VBN cord-281487-x0a9qgjs 158 17 [ [ -LRB- cord-281487-x0a9qgjs 158 18 64 64 CD cord-281487-x0a9qgjs 158 19 ] ] -RRB- cord-281487-x0a9qgjs 158 20 . . . cord-281487-x0a9qgjs 159 1 Immunomodulatory immunomodulatory JJ cord-281487-x0a9qgjs 159 2 agents agent NNS cord-281487-x0a9qgjs 159 3 have have VBP cord-281487-x0a9qgjs 159 4 been be VBN cord-281487-x0a9qgjs 159 5 studied study VBN cord-281487-x0a9qgjs 159 6 and and CC cord-281487-x0a9qgjs 159 7 applied apply VBN cord-281487-x0a9qgjs 159 8 to to TO cord-281487-x0a9qgjs 159 9 reduce reduce VB cord-281487-x0a9qgjs 159 10 systemic systemic JJ cord-281487-x0a9qgjs 159 11 inflammation inflammation NN cord-281487-x0a9qgjs 159 12 to to TO cord-281487-x0a9qgjs 159 13 try try VB cord-281487-x0a9qgjs 159 14 and and CC cord-281487-x0a9qgjs 159 15 prevent prevent VB cord-281487-x0a9qgjs 159 16 multiorgan multiorgan NNP cord-281487-x0a9qgjs 159 17 dysfunction dysfunction NN cord-281487-x0a9qgjs 159 18 , , , cord-281487-x0a9qgjs 159 19 but but CC cord-281487-x0a9qgjs 159 20 with with IN cord-281487-x0a9qgjs 159 21 exception exception NN cord-281487-x0a9qgjs 159 22 of of IN cord-281487-x0a9qgjs 159 23 dexamethasone dexamethasone NN cord-281487-x0a9qgjs 159 24 , , , cord-281487-x0a9qgjs 159 25 remain remain VBP cord-281487-x0a9qgjs 159 26 under under IN cord-281487-x0a9qgjs 159 27 off off IN cord-281487-x0a9qgjs 159 28 - - HYPH cord-281487-x0a9qgjs 159 29 label label NN cord-281487-x0a9qgjs 159 30 or or CC cord-281487-x0a9qgjs 159 31 investigational investigational JJ cord-281487-x0a9qgjs 159 32 use use NN cord-281487-x0a9qgjs 159 33 . . . cord-281487-x0a9qgjs 160 1 Supportive supportive JJ cord-281487-x0a9qgjs 160 2 therapy therapy NN cord-281487-x0a9qgjs 160 3 includes include VBZ cord-281487-x0a9qgjs 160 4 management management NN cord-281487-x0a9qgjs 160 5 of of IN cord-281487-x0a9qgjs 160 6 hypoxia hypoxia NN cord-281487-x0a9qgjs 160 7 , , , cord-281487-x0a9qgjs 160 8 fluid fluid JJ cord-281487-x0a9qgjs 160 9 therapy therapy NN cord-281487-x0a9qgjs 160 10 , , , cord-281487-x0a9qgjs 160 11 medication medication NN cord-281487-x0a9qgjs 160 12 adjustments adjustment NNS cord-281487-x0a9qgjs 160 13 , , , cord-281487-x0a9qgjs 160 14 and and CC cord-281487-x0a9qgjs 160 15 control control NN cord-281487-x0a9qgjs 160 16 of of IN cord-281487-x0a9qgjs 160 17 symptoms symptom NNS cord-281487-x0a9qgjs 160 18 such such JJ cord-281487-x0a9qgjs 160 19 as as IN cord-281487-x0a9qgjs 160 20 fever fever NN cord-281487-x0a9qgjs 160 21 , , , cord-281487-x0a9qgjs 160 22 cough cough NN cord-281487-x0a9qgjs 160 23 , , , cord-281487-x0a9qgjs 160 24 and and CC cord-281487-x0a9qgjs 160 25 diarrhea diarrhea NN cord-281487-x0a9qgjs 160 26 . . . cord-281487-x0a9qgjs 161 1 Considering consider VBG cord-281487-x0a9qgjs 161 2 that that DT cord-281487-x0a9qgjs 161 3 acute acute JJ cord-281487-x0a9qgjs 161 4 respiratory respiratory JJ cord-281487-x0a9qgjs 161 5 distress distress NN cord-281487-x0a9qgjs 161 6 syndrome syndrome NN cord-281487-x0a9qgjs 161 7 ( ( -LRB- cord-281487-x0a9qgjs 161 8 ARDS ARDS NNP cord-281487-x0a9qgjs 161 9 ) ) -RRB- cord-281487-x0a9qgjs 161 10 is be VBZ cord-281487-x0a9qgjs 161 11 one one CD cord-281487-x0a9qgjs 161 12 of of IN cord-281487-x0a9qgjs 161 13 the the DT cord-281487-x0a9qgjs 161 14 most most RBS cord-281487-x0a9qgjs 161 15 severe severe JJ cord-281487-x0a9qgjs 161 16 complications complication NNS cord-281487-x0a9qgjs 161 17 in in IN cord-281487-x0a9qgjs 161 18 patients patient NNS cord-281487-x0a9qgjs 161 19 with with IN cord-281487-x0a9qgjs 161 20 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 161 21 and and CC cord-281487-x0a9qgjs 161 22 a a DT cord-281487-x0a9qgjs 161 23 leading leading JJ cord-281487-x0a9qgjs 161 24 cause cause NN cord-281487-x0a9qgjs 161 25 of of IN cord-281487-x0a9qgjs 161 26 death death NN cord-281487-x0a9qgjs 161 27 ( ( -LRB- cord-281487-x0a9qgjs 161 28 Table table NN cord-281487-x0a9qgjs 161 29 2 2 CD cord-281487-x0a9qgjs 161 30 ) ) -RRB- cord-281487-x0a9qgjs 161 31 [ [ -LRB- cord-281487-x0a9qgjs 161 32 65 65 CD cord-281487-x0a9qgjs 161 33 ] ] -RRB- cord-281487-x0a9qgjs 161 34 , , , cord-281487-x0a9qgjs 161 35 patients patient NNS cord-281487-x0a9qgjs 161 36 requiring require VBG cord-281487-x0a9qgjs 161 37 mechanical mechanical JJ cord-281487-x0a9qgjs 161 38 ventilation ventilation NN cord-281487-x0a9qgjs 161 39 should should MD cord-281487-x0a9qgjs 161 40 be be VB cord-281487-x0a9qgjs 161 41 managed manage VBN cord-281487-x0a9qgjs 161 42 per per IN cord-281487-x0a9qgjs 161 43 standard standard NN cord-281487-x0a9qgjs 161 44 of of IN cord-281487-x0a9qgjs 161 45 care care NN cord-281487-x0a9qgjs 161 46 practices practice NNS cord-281487-x0a9qgjs 161 47 for for IN cord-281487-x0a9qgjs 161 48 ARDS ARDS NNP cord-281487-x0a9qgjs 161 49 . . . cord-281487-x0a9qgjs 162 1 Proning Proning NNP cord-281487-x0a9qgjs 162 2 may may MD cord-281487-x0a9qgjs 162 3 be be VB cord-281487-x0a9qgjs 162 4 required require VBN cord-281487-x0a9qgjs 162 5 due due IN cord-281487-x0a9qgjs 162 6 to to IN cord-281487-x0a9qgjs 162 7 the the DT cord-281487-x0a9qgjs 162 8 distribution distribution NN cord-281487-x0a9qgjs 162 9 of of IN cord-281487-x0a9qgjs 162 10 parenchymal parenchymal NN cord-281487-x0a9qgjs 162 11 changes change NNS cord-281487-x0a9qgjs 162 12 , , , cord-281487-x0a9qgjs 162 13 and and CC cord-281487-x0a9qgjs 162 14 in in IN cord-281487-x0a9qgjs 162 15 some some DT cord-281487-x0a9qgjs 162 16 centers center NNS cord-281487-x0a9qgjs 162 17 is be VBZ cord-281487-x0a9qgjs 162 18 initiated initiate VBN cord-281487-x0a9qgjs 162 19 prior prior RB cord-281487-x0a9qgjs 162 20 to to IN cord-281487-x0a9qgjs 162 21 intubation intubation NN cord-281487-x0a9qgjs 162 22 [ [ -LRB- cord-281487-x0a9qgjs 162 23 66 66 CD cord-281487-x0a9qgjs 162 24 ] ] -RRB- cord-281487-x0a9qgjs 162 25 . . . cord-281487-x0a9qgjs 163 1 The the DT cord-281487-x0a9qgjs 163 2 optimal optimal JJ cord-281487-x0a9qgjs 163 3 fluid fluid NN cord-281487-x0a9qgjs 163 4 therapy therapy NN cord-281487-x0a9qgjs 163 5 for for IN cord-281487-x0a9qgjs 163 6 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 163 7 patients patient NNS cord-281487-x0a9qgjs 163 8 has have VBZ cord-281487-x0a9qgjs 163 9 not not RB cord-281487-x0a9qgjs 163 10 been be VBN cord-281487-x0a9qgjs 163 11 established establish VBN cord-281487-x0a9qgjs 163 12 but but CC cord-281487-x0a9qgjs 163 13 may may MD cord-281487-x0a9qgjs 163 14 need need VB cord-281487-x0a9qgjs 163 15 to to TO cord-281487-x0a9qgjs 163 16 be be VB cord-281487-x0a9qgjs 163 17 individualized individualize VBN cord-281487-x0a9qgjs 163 18 based base VBN cord-281487-x0a9qgjs 163 19 on on IN cord-281487-x0a9qgjs 163 20 the the DT cord-281487-x0a9qgjs 163 21 presence presence NN cord-281487-x0a9qgjs 163 22 of of IN cord-281487-x0a9qgjs 163 23 AKI AKI NNP cord-281487-x0a9qgjs 163 24 , , , cord-281487-x0a9qgjs 163 25 Sepsis sepsis NN cord-281487-x0a9qgjs 163 26 , , , cord-281487-x0a9qgjs 163 27 or or CC cord-281487-x0a9qgjs 163 28 ARDS ARDS NNP cord-281487-x0a9qgjs 163 29 [ [ -LRB- cord-281487-x0a9qgjs 163 30 37 37 CD cord-281487-x0a9qgjs 163 31 , , , cord-281487-x0a9qgjs 163 32 67 67 CD cord-281487-x0a9qgjs 163 33 ] ] -RRB- cord-281487-x0a9qgjs 163 34 . . . cord-281487-x0a9qgjs 164 1 As as IN cord-281487-x0a9qgjs 164 2 the the DT cord-281487-x0a9qgjs 164 3 risk risk NN cord-281487-x0a9qgjs 164 4 of of IN cord-281487-x0a9qgjs 164 5 AKI AKI NNP cord-281487-x0a9qgjs 164 6 is be VBZ cord-281487-x0a9qgjs 164 7 high high JJ cord-281487-x0a9qgjs 164 8 in in IN cord-281487-x0a9qgjs 164 9 patients patient NNS cord-281487-x0a9qgjs 164 10 transplant transplant NN cord-281487-x0a9qgjs 164 11 recipients recipient NNS cord-281487-x0a9qgjs 164 12 with with IN cord-281487-x0a9qgjs 164 13 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 164 14 , , , cord-281487-x0a9qgjs 164 15 avoidance avoidance NN cord-281487-x0a9qgjs 164 16 of of IN cord-281487-x0a9qgjs 164 17 non non JJ cord-281487-x0a9qgjs 164 18 - - JJ cord-281487-x0a9qgjs 164 19 essential essential JJ cord-281487-x0a9qgjs 164 20 nephrotoxic nephrotoxic JJ cord-281487-x0a9qgjs 164 21 agents agent NNS cord-281487-x0a9qgjs 164 22 may may MD cord-281487-x0a9qgjs 164 23 also also RB cord-281487-x0a9qgjs 164 24 be be VB cord-281487-x0a9qgjs 164 25 advisable advisable JJ cord-281487-x0a9qgjs 164 26 [ [ -LRB- cord-281487-x0a9qgjs 164 27 21 21 CD cord-281487-x0a9qgjs 164 28 , , , cord-281487-x0a9qgjs 164 29 30 30 CD cord-281487-x0a9qgjs 164 30 ] ] -RRB- cord-281487-x0a9qgjs 164 31 . . . cord-281487-x0a9qgjs 165 1 The the DT cord-281487-x0a9qgjs 165 2 use use NN cord-281487-x0a9qgjs 165 3 of of IN cord-281487-x0a9qgjs 165 4 angiotensin angiotensin NN cord-281487-x0a9qgjs 165 5 - - HYPH cord-281487-x0a9qgjs 165 6 converting convert VBG cord-281487-x0a9qgjs 165 7 enzyme enzyme NN cord-281487-x0a9qgjs 165 8 inhibitors inhibitor NNS cord-281487-x0a9qgjs 165 9 and and CC cord-281487-x0a9qgjs 165 10 angiotensin angiotensin NN cord-281487-x0a9qgjs 165 11 receptor receptor NN cord-281487-x0a9qgjs 165 12 blockers blocker NNS cord-281487-x0a9qgjs 165 13 ( ( -LRB- cord-281487-x0a9qgjs 165 14 ACEI ACEI NNP cord-281487-x0a9qgjs 165 15 / / SYM cord-281487-x0a9qgjs 165 16 ARBs arb NNS cord-281487-x0a9qgjs 165 17 ) ) -RRB- cord-281487-x0a9qgjs 165 18 has have VBZ cord-281487-x0a9qgjs 165 19 been be VBN cord-281487-x0a9qgjs 165 20 controversial controversial JJ cord-281487-x0a9qgjs 165 21 due due IN cord-281487-x0a9qgjs 165 22 to to IN cord-281487-x0a9qgjs 165 23 concerns concern NNS cord-281487-x0a9qgjs 165 24 that that WDT cord-281487-x0a9qgjs 165 25 may may MD cord-281487-x0a9qgjs 165 26 increase increase VB cord-281487-x0a9qgjs 165 27 susceptibility susceptibility NN cord-281487-x0a9qgjs 165 28 to to IN cord-281487-x0a9qgjs 165 29 the the DT cord-281487-x0a9qgjs 165 30 SARS SARS NNP cord-281487-x0a9qgjs 165 31 - - HYPH cord-281487-x0a9qgjs 165 32 CoV-2 CoV-2 NNP cord-281487-x0a9qgjs 165 33 [ [ -LRB- cord-281487-x0a9qgjs 165 34 6 6 CD cord-281487-x0a9qgjs 165 35 ] ] -RRB- cord-281487-x0a9qgjs 165 36 . . . cord-281487-x0a9qgjs 166 1 In in IN cord-281487-x0a9qgjs 166 2 recently recently RB cord-281487-x0a9qgjs 166 3 published publish VBN cord-281487-x0a9qgjs 166 4 studies study NNS cord-281487-x0a9qgjs 166 5 , , , cord-281487-x0a9qgjs 166 6 use use NN cord-281487-x0a9qgjs 166 7 of of IN cord-281487-x0a9qgjs 166 8 ACEI ACEI NNP cord-281487-x0a9qgjs 166 9 / / SYM cord-281487-x0a9qgjs 166 10 ARBs arb NNS cord-281487-x0a9qgjs 166 11 before before IN cord-281487-x0a9qgjs 166 12 or or CC cord-281487-x0a9qgjs 166 13 during during IN cord-281487-x0a9qgjs 166 14 hospitalization hospitalization NN cord-281487-x0a9qgjs 166 15 was be VBD cord-281487-x0a9qgjs 166 16 not not RB cord-281487-x0a9qgjs 166 17 associated associate VBN cord-281487-x0a9qgjs 166 18 with with IN cord-281487-x0a9qgjs 166 19 mortality mortality NN cord-281487-x0a9qgjs 166 20 among among IN cord-281487-x0a9qgjs 166 21 hypertensive hypertensive JJ cord-281487-x0a9qgjs 166 22 patients patient NNS cord-281487-x0a9qgjs 166 23 with with IN cord-281487-x0a9qgjs 166 24 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 166 25 [ [ -LRB- cord-281487-x0a9qgjs 166 26 68 68 CD cord-281487-x0a9qgjs 166 27 , , , cord-281487-x0a9qgjs 166 28 69 69 CD cord-281487-x0a9qgjs 166 29 ] ] -RRB- cord-281487-x0a9qgjs 166 30 , , , cord-281487-x0a9qgjs 166 31 and and CC cord-281487-x0a9qgjs 166 32 thus thus RB cord-281487-x0a9qgjs 166 33 should should MD cord-281487-x0a9qgjs 166 34 be be VB cord-281487-x0a9qgjs 166 35 maintained maintain VBN cord-281487-x0a9qgjs 166 36 as as RB cord-281487-x0a9qgjs 166 37 clinically clinically RB cord-281487-x0a9qgjs 166 38 indicated indicate VBN cord-281487-x0a9qgjs 166 39 . . . cord-281487-x0a9qgjs 167 1 The the DT cord-281487-x0a9qgjs 167 2 ISTH ISTH NNP cord-281487-x0a9qgjs 167 3 recommends recommend VBZ cord-281487-x0a9qgjs 167 4 prophylactic prophylactic JJ cord-281487-x0a9qgjs 167 5 dose dose NN cord-281487-x0a9qgjs 167 6 low low JJ cord-281487-x0a9qgjs 167 7 molecular molecular JJ cord-281487-x0a9qgjs 167 8 weight weight NN cord-281487-x0a9qgjs 167 9 heparin heparin NN cord-281487-x0a9qgjs 167 10 in in IN cord-281487-x0a9qgjs 167 11 patients patient NNS cord-281487-x0a9qgjs 167 12 with with IN cord-281487-x0a9qgjs 167 13 coagulopathy coagulopathy NN cord-281487-x0a9qgjs 167 14 ( ( -LRB- cord-281487-x0a9qgjs 167 15 D d NN cord-281487-x0a9qgjs 167 16 - - HYPH cord-281487-x0a9qgjs 167 17 dimer dimer NN cord-281487-x0a9qgjs 167 18 > > XX cord-281487-x0a9qgjs 168 1 3 3 CD cord-281487-x0a9qgjs 168 2 to to IN cord-281487-x0a9qgjs 168 3 4 4 CD cord-281487-x0a9qgjs 168 4 times time NNS cord-281487-x0a9qgjs 168 5 , , , cord-281487-x0a9qgjs 168 6 prolonged prolonged JJ cord-281487-x0a9qgjs 168 7 prothrombin prothrombin NN cord-281487-x0a9qgjs 168 8 time time NN cord-281487-x0a9qgjs 168 9 , , , cord-281487-x0a9qgjs 168 10 platelet platelet NN cord-281487-x0a9qgjs 168 11 count count VBP cord-281487-x0a9qgjs 168 12 < < XX cord-281487-x0a9qgjs 168 13 100 100 CD cord-281487-x0a9qgjs 168 14 × × NN cord-281487-x0a9qgjs 168 15 10 10 CD cord-281487-x0a9qgjs 168 16 3 3 CD cord-281487-x0a9qgjs 168 17 /μL /μl CD cord-281487-x0a9qgjs 168 18 , , , cord-281487-x0a9qgjs 168 19 or or CC cord-281487-x0a9qgjs 168 20 fibrinogen fibrinogen NN cord-281487-x0a9qgjs 168 21 < < XX cord-281487-x0a9qgjs 168 22 2.0 2.0 CD cord-281487-x0a9qgjs 168 23 g g NN cord-281487-x0a9qgjs 168 24 / / SYM cord-281487-x0a9qgjs 168 25 L L NNP cord-281487-x0a9qgjs 168 26 ) ) -RRB- cord-281487-x0a9qgjs 168 27 and and CC cord-281487-x0a9qgjs 168 28 patients patient NNS cord-281487-x0a9qgjs 168 29 hospitalized hospitalize VBN cord-281487-x0a9qgjs 168 30 for for IN cord-281487-x0a9qgjs 168 31 COVID-19 covid-19 NN cord-281487-x0a9qgjs 168 32 in in IN cord-281487-x0a9qgjs 168 33 the the DT cord-281487-x0a9qgjs 168 34 absence absence NN cord-281487-x0a9qgjs 168 35 of of IN cord-281487-x0a9qgjs 168 36 any any DT cord-281487-x0a9qgjs 168 37 bleeding bleeding NN cord-281487-x0a9qgjs 168 38 or or CC cord-281487-x0a9qgjs 168 39 thrombocytopenia thrombocytopenia NN cord-281487-x0a9qgjs 168 40 [ [ -LRB- cord-281487-x0a9qgjs 168 41 29 29 CD cord-281487-x0a9qgjs 168 42 , , , cord-281487-x0a9qgjs 168 43 40 40 CD cord-281487-x0a9qgjs 168 44 ] ] -RRB- cord-281487-x0a9qgjs 168 45 . . . cord-281487-x0a9qgjs 169 1 A a DT cord-281487-x0a9qgjs 169 2 study study NN cord-281487-x0a9qgjs 169 3 demonstrated demonstrate VBD cord-281487-x0a9qgjs 169 4 that that IN cord-281487-x0a9qgjs 169 5 the the DT cord-281487-x0a9qgjs 169 6 use use NN cord-281487-x0a9qgjs 169 7 of of IN cord-281487-x0a9qgjs 169 8 prophylactic prophylactic JJ cord-281487-x0a9qgjs 169 9 LMWH LMWH NNP cord-281487-x0a9qgjs 169 10 was be VBD cord-281487-x0a9qgjs 169 11 associated associate VBN cord-281487-x0a9qgjs 169 12 with with IN cord-281487-x0a9qgjs 169 13 low low JJ cord-281487-x0a9qgjs 169 14 mortality mortality NN cord-281487-x0a9qgjs 169 15 in in IN cord-281487-x0a9qgjs 169 16 patients patient NNS cord-281487-x0a9qgjs 169 17 with with IN cord-281487-x0a9qgjs 169 18 severe severe JJ cord-281487-x0a9qgjs 169 19 COVID-19 covid-19 NN cord-281487-x0a9qgjs 169 20 . . . cord-281487-x0a9qgjs 170 1 The the DT cord-281487-x0a9qgjs 170 2 optimal optimal JJ cord-281487-x0a9qgjs 170 3 regulation regulation NN cord-281487-x0a9qgjs 170 4 of of IN cord-281487-x0a9qgjs 170 5 transplant transplant NN cord-281487-x0a9qgjs 170 6 immunosuppression immunosuppression NN cord-281487-x0a9qgjs 170 7 in in IN cord-281487-x0a9qgjs 170 8 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 170 9 remains remain VBZ cord-281487-x0a9qgjs 170 10 a a DT cord-281487-x0a9qgjs 170 11 challenging challenging JJ cord-281487-x0a9qgjs 170 12 question question NN cord-281487-x0a9qgjs 170 13 , , , cord-281487-x0a9qgjs 170 14 with with IN cord-281487-x0a9qgjs 170 15 a a DT cord-281487-x0a9qgjs 170 16 paucity paucity NN cord-281487-x0a9qgjs 170 17 of of IN cord-281487-x0a9qgjs 170 18 clinical clinical JJ cord-281487-x0a9qgjs 170 19 data datum NNS cord-281487-x0a9qgjs 170 20 for for IN cord-281487-x0a9qgjs 170 21 guidance guidance NN cord-281487-x0a9qgjs 170 22 . . . cord-281487-x0a9qgjs 171 1 Immunosuppressive immunosuppressive JJ cord-281487-x0a9qgjs 171 2 drugs drug NNS cord-281487-x0a9qgjs 171 3 may may MD cord-281487-x0a9qgjs 171 4 prolong prolong VB cord-281487-x0a9qgjs 171 5 viral viral JJ cord-281487-x0a9qgjs 171 6 shedding shedding NN cord-281487-x0a9qgjs 171 7 , , , cord-281487-x0a9qgjs 171 8 have have VBP cord-281487-x0a9qgjs 171 9 beneficial beneficial JJ cord-281487-x0a9qgjs 171 10 anti anti JJ cord-281487-x0a9qgjs 171 11 - - JJ cord-281487-x0a9qgjs 171 12 inflammatory inflammatory JJ cord-281487-x0a9qgjs 171 13 effects effect NNS cord-281487-x0a9qgjs 171 14 , , , cord-281487-x0a9qgjs 171 15 or or CC cord-281487-x0a9qgjs 171 16 even even RB cord-281487-x0a9qgjs 171 17 have have VBP cord-281487-x0a9qgjs 171 18 anti anti JJ cord-281487-x0a9qgjs 171 19 - - JJ cord-281487-x0a9qgjs 171 20 viral viral JJ cord-281487-x0a9qgjs 171 21 properties property NNS cord-281487-x0a9qgjs 171 22 [ [ -LRB- cord-281487-x0a9qgjs 171 23 70 70 CD cord-281487-x0a9qgjs 171 24 ] ] -RRB- cord-281487-x0a9qgjs 171 25 . . . cord-281487-x0a9qgjs 172 1 Little little JJ cord-281487-x0a9qgjs 172 2 is be VBZ cord-281487-x0a9qgjs 172 3 known know VBN cord-281487-x0a9qgjs 172 4 about about IN cord-281487-x0a9qgjs 172 5 the the DT cord-281487-x0a9qgjs 172 6 exact exact JJ cord-281487-x0a9qgjs 172 7 role role NN cord-281487-x0a9qgjs 172 8 of of IN cord-281487-x0a9qgjs 172 9 cyclophilin cyclophilin NNP cord-281487-x0a9qgjs 172 10 in in IN cord-281487-x0a9qgjs 172 11 coronavirus coronavirus NN cord-281487-x0a9qgjs 172 12 replication replication NN cord-281487-x0a9qgjs 172 13 , , , cord-281487-x0a9qgjs 172 14 but but CC cord-281487-x0a9qgjs 172 15 it -PRON- PRP cord-281487-x0a9qgjs 172 16 has have VBZ cord-281487-x0a9qgjs 172 17 been be VBN cord-281487-x0a9qgjs 172 18 reported report VBN cord-281487-x0a9qgjs 172 19 that that IN cord-281487-x0a9qgjs 172 20 cyclosporine cyclosporine NN cord-281487-x0a9qgjs 172 21 , , , cord-281487-x0a9qgjs 172 22 which which WDT cord-281487-x0a9qgjs 172 23 also also RB cord-281487-x0a9qgjs 172 24 binds bind VBZ cord-281487-x0a9qgjs 172 25 cyclophilin cyclophilin NNP cord-281487-x0a9qgjs 172 26 , , , cord-281487-x0a9qgjs 172 27 may may MD cord-281487-x0a9qgjs 172 28 inhibit inhibit VB cord-281487-x0a9qgjs 172 29 the the DT cord-281487-x0a9qgjs 172 30 replication replication NN cord-281487-x0a9qgjs 172 31 of of IN cord-281487-x0a9qgjs 172 32 coronaviruses coronaviruse NNS cord-281487-x0a9qgjs 172 33 at at IN cord-281487-x0a9qgjs 172 34 noncytotoxic noncytotoxic NNP cord-281487-x0a9qgjs 172 35 concentrations concentration NNS cord-281487-x0a9qgjs 172 36 [ [ -LRB- cord-281487-x0a9qgjs 172 37 71 71 CD cord-281487-x0a9qgjs 172 38 , , , cord-281487-x0a9qgjs 172 39 72 72 CD cord-281487-x0a9qgjs 172 40 ] ] -RRB- cord-281487-x0a9qgjs 172 41 . . . cord-281487-x0a9qgjs 173 1 In in IN cord-281487-x0a9qgjs 173 2 vitro vitro FW cord-281487-x0a9qgjs 173 3 , , , cord-281487-x0a9qgjs 173 4 tacrolimus tacrolimus NNP cord-281487-x0a9qgjs 173 5 inhibited inhibit VBD cord-281487-x0a9qgjs 173 6 the the DT cord-281487-x0a9qgjs 173 7 replication replication NN cord-281487-x0a9qgjs 173 8 of of IN cord-281487-x0a9qgjs 173 9 SARS SARS NNP cord-281487-x0a9qgjs 173 10 - - HYPH cord-281487-x0a9qgjs 173 11 CoV CoV NNP cord-281487-x0a9qgjs 173 12 , , , cord-281487-x0a9qgjs 173 13 suggesting suggest VBG cord-281487-x0a9qgjs 173 14 the the DT cord-281487-x0a9qgjs 173 15 requirement requirement NN cord-281487-x0a9qgjs 173 16 of of IN cord-281487-x0a9qgjs 173 17 FK506-binding fk506-binde VBG cord-281487-x0a9qgjs 173 18 proteins protein NNS cord-281487-x0a9qgjs 173 19 for for IN cord-281487-x0a9qgjs 173 20 virus virus NN cord-281487-x0a9qgjs 173 21 growth growth NN cord-281487-x0a9qgjs 173 22 [ [ -LRB- cord-281487-x0a9qgjs 173 23 73 73 CD cord-281487-x0a9qgjs 173 24 ] ] -RRB- cord-281487-x0a9qgjs 173 25 . . . cord-281487-x0a9qgjs 174 1 Further further RB cord-281487-x0a9qgjs 174 2 , , , cord-281487-x0a9qgjs 174 3 CNIs cni NNS cord-281487-x0a9qgjs 174 4 may may MD cord-281487-x0a9qgjs 174 5 be be VB cord-281487-x0a9qgjs 174 6 capable capable JJ cord-281487-x0a9qgjs 174 7 of of IN cord-281487-x0a9qgjs 174 8 reducing reduce VBG cord-281487-x0a9qgjs 174 9 the the DT cord-281487-x0a9qgjs 174 10 frequency frequency NN cord-281487-x0a9qgjs 174 11 of of IN cord-281487-x0a9qgjs 174 12 cytokine cytokine NN cord-281487-x0a9qgjs 174 13 release release NN cord-281487-x0a9qgjs 174 14 syndrome syndrome NN cord-281487-x0a9qgjs 174 15 through through IN cord-281487-x0a9qgjs 174 16 inhibition inhibition NN cord-281487-x0a9qgjs 174 17 of of IN cord-281487-x0a9qgjs 174 18 NFAT NFAT NNP cord-281487-x0a9qgjs 174 19 . . . cord-281487-x0a9qgjs 175 1 However however RB cord-281487-x0a9qgjs 175 2 , , , cord-281487-x0a9qgjs 175 3 the the DT cord-281487-x0a9qgjs 175 4 exact exact JJ cord-281487-x0a9qgjs 175 5 role role NN cord-281487-x0a9qgjs 175 6 of of IN cord-281487-x0a9qgjs 175 7 these these DT cord-281487-x0a9qgjs 175 8 agents agent NNS cord-281487-x0a9qgjs 175 9 for for IN cord-281487-x0a9qgjs 175 10 enhancing enhance VBG cord-281487-x0a9qgjs 175 11 viral viral JJ cord-281487-x0a9qgjs 175 12 clearance clearance NN cord-281487-x0a9qgjs 175 13 in in IN cord-281487-x0a9qgjs 175 14 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 175 15 is be VBZ cord-281487-x0a9qgjs 175 16 unknown unknown JJ cord-281487-x0a9qgjs 175 17 and and CC cord-281487-x0a9qgjs 175 18 merits merit NNS cord-281487-x0a9qgjs 175 19 further further JJ cord-281487-x0a9qgjs 175 20 investigation investigation NN cord-281487-x0a9qgjs 175 21 . . . cord-281487-x0a9qgjs 176 1 Given give VBN cord-281487-x0a9qgjs 176 2 these these DT cord-281487-x0a9qgjs 176 3 in in IN cord-281487-x0a9qgjs 176 4 vitro vitro FW cord-281487-x0a9qgjs 176 5 effects effect NNS cord-281487-x0a9qgjs 176 6 and and CC cord-281487-x0a9qgjs 176 7 the the DT cord-281487-x0a9qgjs 176 8 need need NN cord-281487-x0a9qgjs 176 9 to to TO cord-281487-x0a9qgjs 176 10 maintain maintain VB cord-281487-x0a9qgjs 176 11 some some DT cord-281487-x0a9qgjs 176 12 immunosuppression immunosuppression NN cord-281487-x0a9qgjs 176 13 to to TO cord-281487-x0a9qgjs 176 14 prevent prevent VB cord-281487-x0a9qgjs 176 15 allograft allograft NN cord-281487-x0a9qgjs 176 16 rejection rejection NN cord-281487-x0a9qgjs 176 17 , , , cord-281487-x0a9qgjs 176 18 many many JJ cord-281487-x0a9qgjs 176 19 centers center NNS cord-281487-x0a9qgjs 176 20 , , , cord-281487-x0a9qgjs 176 21 including include VBG cord-281487-x0a9qgjs 176 22 ours -PRON- PRP cord-281487-x0a9qgjs 176 23 , , , cord-281487-x0a9qgjs 176 24 have have VBP cord-281487-x0a9qgjs 176 25 implemented implement VBN cord-281487-x0a9qgjs 176 26 reduction reduction NN cord-281487-x0a9qgjs 176 27 or or CC cord-281487-x0a9qgjs 176 28 holding holding NN cord-281487-x0a9qgjs 176 29 antimetabolite antimetabolite NN cord-281487-x0a9qgjs 176 30 and and CC cord-281487-x0a9qgjs 176 31 continuing continue VBG cord-281487-x0a9qgjs 176 32 the the DT cord-281487-x0a9qgjs 176 33 CNIs cni NNS cord-281487-x0a9qgjs 176 34 and and CC cord-281487-x0a9qgjs 176 35 glucocorticoids glucocorticoid NNS cord-281487-x0a9qgjs 176 36 in in IN cord-281487-x0a9qgjs 176 37 transplant transplant NN cord-281487-x0a9qgjs 176 38 recipients recipient NNS cord-281487-x0a9qgjs 176 39 with with IN cord-281487-x0a9qgjs 176 40 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 176 41 . . . cord-281487-x0a9qgjs 177 1 Others other NNS cord-281487-x0a9qgjs 177 2 have have VBP cord-281487-x0a9qgjs 177 3 recommended recommend VBN cord-281487-x0a9qgjs 177 4 that that IN cord-281487-x0a9qgjs 177 5 CNIs cni NNS cord-281487-x0a9qgjs 177 6 and and CC cord-281487-x0a9qgjs 177 7 the the DT cord-281487-x0a9qgjs 177 8 antimetabolite antimetabolite NN cord-281487-x0a9qgjs 177 9 be be VB cord-281487-x0a9qgjs 177 10 immediately immediately RB cord-281487-x0a9qgjs 177 11 withdrawn withdraw VBN cord-281487-x0a9qgjs 177 12 and and CC cord-281487-x0a9qgjs 177 13 the the DT cord-281487-x0a9qgjs 177 14 glucocorticoid glucocorticoid NN cord-281487-x0a9qgjs 177 15 dosage dosage NN cord-281487-x0a9qgjs 177 16 increased increase VBD cord-281487-x0a9qgjs 177 17 in in IN cord-281487-x0a9qgjs 177 18 KT KT NNP cord-281487-x0a9qgjs 177 19 recipients recipient NNS cord-281487-x0a9qgjs 177 20 with with IN cord-281487-x0a9qgjs 177 21 severe severe JJ cord-281487-x0a9qgjs 177 22 or or CC cord-281487-x0a9qgjs 177 23 rapidly rapidly RB cord-281487-x0a9qgjs 177 24 progressing progress VBG cord-281487-x0a9qgjs 177 25 COVID-19 covid-19 VB cord-281487-x0a9qgjs 177 26 [ [ -LRB- cord-281487-x0a9qgjs 177 27 54 54 CD cord-281487-x0a9qgjs 177 28 , , , cord-281487-x0a9qgjs 177 29 74 74 CD cord-281487-x0a9qgjs 177 30 ] ] -RRB- cord-281487-x0a9qgjs 177 31 . . . cord-281487-x0a9qgjs 178 1 However however RB cord-281487-x0a9qgjs 178 2 , , , cord-281487-x0a9qgjs 178 3 we -PRON- PRP cord-281487-x0a9qgjs 178 4 remain remain VBP cord-281487-x0a9qgjs 178 5 hesitant hesitant JJ cord-281487-x0a9qgjs 178 6 to to TO cord-281487-x0a9qgjs 178 7 recommend recommend VB cord-281487-x0a9qgjs 178 8 complete complete JJ cord-281487-x0a9qgjs 178 9 cessation cessation NN cord-281487-x0a9qgjs 178 10 of of IN cord-281487-x0a9qgjs 178 11 CNIs cni NNS cord-281487-x0a9qgjs 178 12 without without IN cord-281487-x0a9qgjs 178 13 further further JJ cord-281487-x0a9qgjs 178 14 clinical clinical JJ cord-281487-x0a9qgjs 178 15 data datum NNS cord-281487-x0a9qgjs 178 16 to to TO cord-281487-x0a9qgjs 178 17 support support VB cord-281487-x0a9qgjs 178 18 the the DT cord-281487-x0a9qgjs 178 19 safety safety NN cord-281487-x0a9qgjs 178 20 of of IN cord-281487-x0a9qgjs 178 21 this this DT cord-281487-x0a9qgjs 178 22 practice practice NN cord-281487-x0a9qgjs 178 23 . . . cord-281487-x0a9qgjs 179 1 While while IN cord-281487-x0a9qgjs 179 2 there there EX cord-281487-x0a9qgjs 179 3 is be VBZ cord-281487-x0a9qgjs 179 4 literature literature NN cord-281487-x0a9qgjs 179 5 in in IN cord-281487-x0a9qgjs 179 6 the the DT cord-281487-x0a9qgjs 179 7 general general JJ cord-281487-x0a9qgjs 179 8 population population NN cord-281487-x0a9qgjs 179 9 to to TO cord-281487-x0a9qgjs 179 10 support support VB cord-281487-x0a9qgjs 179 11 the the DT cord-281487-x0a9qgjs 179 12 use use NN cord-281487-x0a9qgjs 179 13 of of IN cord-281487-x0a9qgjs 179 14 augmented augment VBN cord-281487-x0a9qgjs 179 15 dexamethasone dexamethasone NN cord-281487-x0a9qgjs 179 16 in in IN cord-281487-x0a9qgjs 179 17 severely severely RB cord-281487-x0a9qgjs 179 18 ill ill JJ cord-281487-x0a9qgjs 180 1 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 180 2 recipients recipient NNS cord-281487-x0a9qgjs 180 3 , , , cord-281487-x0a9qgjs 180 4 these these DT cord-281487-x0a9qgjs 180 5 studies study NNS cord-281487-x0a9qgjs 180 6 have have VBP cord-281487-x0a9qgjs 180 7 not not RB cord-281487-x0a9qgjs 180 8 reported report VBN cord-281487-x0a9qgjs 180 9 the the DT cord-281487-x0a9qgjs 180 10 outcomes outcome NNS cord-281487-x0a9qgjs 180 11 of of IN cord-281487-x0a9qgjs 180 12 this this DT cord-281487-x0a9qgjs 180 13 augmentation augmentation NN cord-281487-x0a9qgjs 180 14 in in IN cord-281487-x0a9qgjs 180 15 immunocompromised immunocompromised JJ cord-281487-x0a9qgjs 180 16 individuals individual NNS cord-281487-x0a9qgjs 180 17 . . . cord-281487-x0a9qgjs 181 1 In in IN cord-281487-x0a9qgjs 181 2 a a DT cord-281487-x0a9qgjs 181 3 preliminary preliminary JJ cord-281487-x0a9qgjs 181 4 report report NN cord-281487-x0a9qgjs 181 5 by by IN cord-281487-x0a9qgjs 181 6 Horby Horby NNP cord-281487-x0a9qgjs 181 7 et et NNP cord-281487-x0a9qgjs 181 8 al al NNP cord-281487-x0a9qgjs 181 9 . . . cord-281487-x0a9qgjs 182 1 , , , cord-281487-x0a9qgjs 182 2 dexamethasone dexamethasone NNP cord-281487-x0a9qgjs 182 3 ( ( -LRB- cord-281487-x0a9qgjs 182 4 6 6 CD cord-281487-x0a9qgjs 182 5 mg mg NNP cord-281487-x0a9qgjs 182 6 daily daily RB cord-281487-x0a9qgjs 182 7 for for IN cord-281487-x0a9qgjs 182 8 up up IN cord-281487-x0a9qgjs 182 9 to to TO cord-281487-x0a9qgjs 182 10 10 10 CD cord-281487-x0a9qgjs 182 11 days day NNS cord-281487-x0a9qgjs 182 12 ) ) -RRB- cord-281487-x0a9qgjs 182 13 reduced reduce VBN cord-281487-x0a9qgjs 182 14 mortality mortality NN cord-281487-x0a9qgjs 182 15 among among IN cord-281487-x0a9qgjs 182 16 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 182 17 patients patient NNS cord-281487-x0a9qgjs 182 18 receiving receive VBG cord-281487-x0a9qgjs 182 19 mechanical mechanical JJ cord-281487-x0a9qgjs 182 20 ventilation ventilation NN cord-281487-x0a9qgjs 182 21 or or CC cord-281487-x0a9qgjs 182 22 oxygen oxygen NN cord-281487-x0a9qgjs 182 23 [ [ -LRB- cord-281487-x0a9qgjs 182 24 75 75 CD cord-281487-x0a9qgjs 182 25 ] ] -RRB- cord-281487-x0a9qgjs 182 26 , , , cord-281487-x0a9qgjs 182 27 and and CC cord-281487-x0a9qgjs 182 28 this this DT cord-281487-x0a9qgjs 182 29 has have VBZ cord-281487-x0a9qgjs 182 30 been be VBN cord-281487-x0a9qgjs 182 31 incorporated incorporate VBN cord-281487-x0a9qgjs 182 32 into into IN cord-281487-x0a9qgjs 182 33 routine routine JJ cord-281487-x0a9qgjs 182 34 practice practice NN cord-281487-x0a9qgjs 182 35 . . . cord-281487-x0a9qgjs 183 1 However however RB cord-281487-x0a9qgjs 183 2 , , , cord-281487-x0a9qgjs 183 3 optimal optimal JJ cord-281487-x0a9qgjs 183 4 adjustment adjustment NN cord-281487-x0a9qgjs 183 5 of of IN cord-281487-x0a9qgjs 183 6 immunosuppression immunosuppression NN cord-281487-x0a9qgjs 183 7 and and CC cord-281487-x0a9qgjs 183 8 return return VB cord-281487-x0a9qgjs 183 9 to to IN cord-281487-x0a9qgjs 183 10 maintenance maintenance NN cord-281487-x0a9qgjs 183 11 dosing dosing NN cord-281487-x0a9qgjs 183 12 remains remain VBZ cord-281487-x0a9qgjs 183 13 unknown unknown JJ cord-281487-x0a9qgjs 183 14 . . . cord-281487-x0a9qgjs 184 1 As as IN cord-281487-x0a9qgjs 184 2 we -PRON- PRP cord-281487-x0a9qgjs 184 3 have have VBP cord-281487-x0a9qgjs 184 4 previously previously RB cord-281487-x0a9qgjs 184 5 reported report VBN cord-281487-x0a9qgjs 184 6 , , , cord-281487-x0a9qgjs 184 7 permanent permanent JJ cord-281487-x0a9qgjs 184 8 discontinuation discontinuation NN cord-281487-x0a9qgjs 184 9 of of IN cord-281487-x0a9qgjs 184 10 the the DT cord-281487-x0a9qgjs 184 11 antimetabolite antimetabolite NN cord-281487-x0a9qgjs 184 12 in in IN cord-281487-x0a9qgjs 184 13 KT KT NNP cord-281487-x0a9qgjs 184 14 patients patient NNS cord-281487-x0a9qgjs 184 15 with with IN cord-281487-x0a9qgjs 184 16 a a DT cord-281487-x0a9qgjs 184 17 severe severe JJ cord-281487-x0a9qgjs 184 18 viral viral JJ cord-281487-x0a9qgjs 184 19 infection infection NN cord-281487-x0a9qgjs 184 20 such such JJ cord-281487-x0a9qgjs 184 21 as as IN cord-281487-x0a9qgjs 184 22 CMV CMV NNP cord-281487-x0a9qgjs 184 23 and and CC cord-281487-x0a9qgjs 184 24 BK BK NNP cord-281487-x0a9qgjs 184 25 virus virus NN cord-281487-x0a9qgjs 184 26 is be VBZ cord-281487-x0a9qgjs 184 27 safe safe JJ cord-281487-x0a9qgjs 184 28 and and CC cord-281487-x0a9qgjs 184 29 effective effective JJ cord-281487-x0a9qgjs 184 30 [ [ -LRB- cord-281487-x0a9qgjs 184 31 76 76 CD cord-281487-x0a9qgjs 184 32 , , , cord-281487-x0a9qgjs 184 33 77 77 CD cord-281487-x0a9qgjs 184 34 ] ] -RRB- cord-281487-x0a9qgjs 184 35 . . . cord-281487-x0a9qgjs 185 1 However however RB cord-281487-x0a9qgjs 185 2 , , , cord-281487-x0a9qgjs 185 3 there there EX cord-281487-x0a9qgjs 185 4 are be VBP cord-281487-x0a9qgjs 185 5 less less JJR cord-281487-x0a9qgjs 185 6 data datum NNS cord-281487-x0a9qgjs 185 7 about about IN cord-281487-x0a9qgjs 185 8 the the DT cord-281487-x0a9qgjs 185 9 safety safety NN cord-281487-x0a9qgjs 185 10 of of IN cord-281487-x0a9qgjs 185 11 the the DT cord-281487-x0a9qgjs 185 12 prolonged prolong VBN cord-281487-x0a9qgjs 185 13 cessation cessation NN cord-281487-x0a9qgjs 185 14 of of IN cord-281487-x0a9qgjs 185 15 antimetabolites antimetabolite NNS cord-281487-x0a9qgjs 185 16 in in IN cord-281487-x0a9qgjs 185 17 other other JJ cord-281487-x0a9qgjs 185 18 organ organ NN cord-281487-x0a9qgjs 185 19 transplants transplant NNS cord-281487-x0a9qgjs 185 20 , , , cord-281487-x0a9qgjs 185 21 particularly particularly RB cord-281487-x0a9qgjs 185 22 for for IN cord-281487-x0a9qgjs 185 23 viruses virus NNS cord-281487-x0a9qgjs 185 24 in in IN cord-281487-x0a9qgjs 185 25 whom whom WP cord-281487-x0a9qgjs 185 26 the the DT cord-281487-x0a9qgjs 185 27 disease disease NN cord-281487-x0a9qgjs 185 28 severity severity NN cord-281487-x0a9qgjs 185 29 is be VBZ cord-281487-x0a9qgjs 185 30 characterized characterize VBN cord-281487-x0a9qgjs 185 31 by by IN cord-281487-x0a9qgjs 185 32 a a DT cord-281487-x0a9qgjs 185 33 hyperactive hyperactive JJ cord-281487-x0a9qgjs 185 34 immune immune JJ cord-281487-x0a9qgjs 185 35 response response NN cord-281487-x0a9qgjs 185 36 , , , cord-281487-x0a9qgjs 185 37 or or CC cord-281487-x0a9qgjs 185 38 for for IN cord-281487-x0a9qgjs 185 39 conditions condition NNS cord-281487-x0a9qgjs 185 40 such such JJ cord-281487-x0a9qgjs 185 41 as as IN cord-281487-x0a9qgjs 185 42 in in IN cord-281487-x0a9qgjs 185 43 thoracic thoracic JJ cord-281487-x0a9qgjs 185 44 transplant transplant NN cord-281487-x0a9qgjs 185 45 where where WRB cord-281487-x0a9qgjs 185 46 respiratory respiratory JJ cord-281487-x0a9qgjs 185 47 viral viral JJ cord-281487-x0a9qgjs 185 48 infections infection NNS cord-281487-x0a9qgjs 185 49 have have VBP cord-281487-x0a9qgjs 185 50 been be VBN cord-281487-x0a9qgjs 185 51 shown show VBN cord-281487-x0a9qgjs 185 52 to to TO cord-281487-x0a9qgjs 185 53 trigger trigger VB cord-281487-x0a9qgjs 185 54 immune immune JJ cord-281487-x0a9qgjs 185 55 responses response NNS cord-281487-x0a9qgjs 185 56 that that WDT cord-281487-x0a9qgjs 185 57 induce induce VBP cord-281487-x0a9qgjs 185 58 chronic chronic JJ cord-281487-x0a9qgjs 185 59 allograft allograft NN cord-281487-x0a9qgjs 185 60 dysfunction dysfunction NN cord-281487-x0a9qgjs 185 61 [ [ -LRB- cord-281487-x0a9qgjs 185 62 78 78 CD cord-281487-x0a9qgjs 185 63 ] ] -RRB- cord-281487-x0a9qgjs 185 64 [ [ -LRB- cord-281487-x0a9qgjs 185 65 79 79 CD cord-281487-x0a9qgjs 185 66 ] ] -RRB- cord-281487-x0a9qgjs 185 67 [ [ -LRB- cord-281487-x0a9qgjs 185 68 80 80 CD cord-281487-x0a9qgjs 185 69 ] ] -RRB- cord-281487-x0a9qgjs 185 70 [ [ -LRB- cord-281487-x0a9qgjs 185 71 81 81 CD cord-281487-x0a9qgjs 185 72 ] ] -RRB- cord-281487-x0a9qgjs 185 73 . . . cord-281487-x0a9qgjs 186 1 There there EX cord-281487-x0a9qgjs 186 2 has have VBZ cord-281487-x0a9qgjs 186 3 been be VBN cord-281487-x0a9qgjs 186 4 much much JJ cord-281487-x0a9qgjs 186 5 interest interest NN cord-281487-x0a9qgjs 186 6 in in IN cord-281487-x0a9qgjs 186 7 supplements supplement NNS cord-281487-x0a9qgjs 186 8 such such JJ cord-281487-x0a9qgjs 186 9 as as IN cord-281487-x0a9qgjs 186 10 vitamin vitamin NN cord-281487-x0a9qgjs 186 11 D d NN cord-281487-x0a9qgjs 186 12 and and CC cord-281487-x0a9qgjs 186 13 melatonin melatonin NN cord-281487-x0a9qgjs 186 14 in in IN cord-281487-x0a9qgjs 186 15 adjunctive adjunctive JJ cord-281487-x0a9qgjs 186 16 therapy therapy NN cord-281487-x0a9qgjs 186 17 for for IN cord-281487-x0a9qgjs 186 18 patients patient NNS cord-281487-x0a9qgjs 186 19 with with IN cord-281487-x0a9qgjs 186 20 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 186 21 due due IN cord-281487-x0a9qgjs 186 22 to to IN cord-281487-x0a9qgjs 186 23 their -PRON- PRP$ cord-281487-x0a9qgjs 186 24 anti anti JJ cord-281487-x0a9qgjs 186 25 - - JJ cord-281487-x0a9qgjs 186 26 inflammatory inflammatory JJ cord-281487-x0a9qgjs 186 27 and and CC cord-281487-x0a9qgjs 186 28 anti anti JJ cord-281487-x0a9qgjs 186 29 - - JJ cord-281487-x0a9qgjs 186 30 oxidant oxidant JJ cord-281487-x0a9qgjs 186 31 properties property NNS cord-281487-x0a9qgjs 186 32 and and CC cord-281487-x0a9qgjs 186 33 low low JJ cord-281487-x0a9qgjs 186 34 risk risk NN cord-281487-x0a9qgjs 186 35 of of IN cord-281487-x0a9qgjs 186 36 harm harm NN cord-281487-x0a9qgjs 186 37 . . . cord-281487-x0a9qgjs 187 1 Inadequate inadequate JJ cord-281487-x0a9qgjs 187 2 vitamin vitamin NN cord-281487-x0a9qgjs 187 3 D d NN cord-281487-x0a9qgjs 187 4 levels level NNS cord-281487-x0a9qgjs 187 5 have have VBP cord-281487-x0a9qgjs 187 6 been be VBN cord-281487-x0a9qgjs 187 7 found find VBN cord-281487-x0a9qgjs 187 8 in in IN cord-281487-x0a9qgjs 187 9 > > $ cord-281487-x0a9qgjs 187 10 70 70 CD cord-281487-x0a9qgjs 187 11 % % NN cord-281487-x0a9qgjs 187 12 abdominal abdominal JJ cord-281487-x0a9qgjs 187 13 transplant transplant NN cord-281487-x0a9qgjs 187 14 recipients recipient NNS cord-281487-x0a9qgjs 187 15 [ [ -LRB- cord-281487-x0a9qgjs 187 16 82 82 CD cord-281487-x0a9qgjs 187 17 ] ] -RRB- cord-281487-x0a9qgjs 187 18 and and CC cord-281487-x0a9qgjs 187 19 may may MD cord-281487-x0a9qgjs 187 20 be be VB cord-281487-x0a9qgjs 187 21 exacerbated exacerbate VBN cord-281487-x0a9qgjs 187 22 by by IN cord-281487-x0a9qgjs 187 23 glucocorticoids glucocorticoid NNS cord-281487-x0a9qgjs 187 24 , , , cord-281487-x0a9qgjs 187 25 CNIs cni NNS cord-281487-x0a9qgjs 187 26 , , , cord-281487-x0a9qgjs 187 27 low low JJ cord-281487-x0a9qgjs 187 28 sun sun NN cord-281487-x0a9qgjs 187 29 exposure exposure NN cord-281487-x0a9qgjs 187 30 , , , cord-281487-x0a9qgjs 187 31 and and CC cord-281487-x0a9qgjs 187 32 inadequate inadequate JJ cord-281487-x0a9qgjs 187 33 dietary dietary JJ cord-281487-x0a9qgjs 187 34 intake intake NN cord-281487-x0a9qgjs 187 35 [ [ -LRB- cord-281487-x0a9qgjs 187 36 83 83 CD cord-281487-x0a9qgjs 187 37 ] ] -RRB- cord-281487-x0a9qgjs 187 38 . . . cord-281487-x0a9qgjs 188 1 Low low JJ cord-281487-x0a9qgjs 188 2 vitamin vitamin NN cord-281487-x0a9qgjs 188 3 D d NN cord-281487-x0a9qgjs 188 4 levels level NNS cord-281487-x0a9qgjs 188 5 have have VBP cord-281487-x0a9qgjs 188 6 been be VBN cord-281487-x0a9qgjs 188 7 associated associate VBN cord-281487-x0a9qgjs 188 8 with with IN cord-281487-x0a9qgjs 188 9 a a DT cord-281487-x0a9qgjs 188 10 high high JJ cord-281487-x0a9qgjs 188 11 risk risk NN cord-281487-x0a9qgjs 188 12 of of IN cord-281487-x0a9qgjs 188 13 CMV CMV NNP cord-281487-x0a9qgjs 188 14 infection infection NN cord-281487-x0a9qgjs 188 15 and and CC cord-281487-x0a9qgjs 188 16 overall overall JJ cord-281487-x0a9qgjs 188 17 infection infection NN cord-281487-x0a9qgjs 188 18 in in IN cord-281487-x0a9qgjs 188 19 transplant transplant NN cord-281487-x0a9qgjs 188 20 recipients recipient NNS cord-281487-x0a9qgjs 188 21 [ [ -LRB- cord-281487-x0a9qgjs 188 22 84 84 CD cord-281487-x0a9qgjs 188 23 , , , cord-281487-x0a9qgjs 188 24 85 85 CD cord-281487-x0a9qgjs 188 25 ] ] -RRB- cord-281487-x0a9qgjs 188 26 . . . cord-281487-x0a9qgjs 189 1 Further further JJ cord-281487-x0a9qgjs 189 2 meta meta NNP cord-281487-x0a9qgjs 189 3 - - HYPH cord-281487-x0a9qgjs 189 4 analyses analysis NNS cord-281487-x0a9qgjs 189 5 of of IN cord-281487-x0a9qgjs 189 6 RCT RCT NNP cord-281487-x0a9qgjs 189 7 data datum NNS cord-281487-x0a9qgjs 189 8 have have VBP cord-281487-x0a9qgjs 189 9 demonstrated demonstrate VBN cord-281487-x0a9qgjs 189 10 that that IN cord-281487-x0a9qgjs 189 11 vitamin vitamin NN cord-281487-x0a9qgjs 189 12 D d NN cord-281487-x0a9qgjs 189 13 has have VBZ cord-281487-x0a9qgjs 189 14 a a DT cord-281487-x0a9qgjs 189 15 protective protective JJ cord-281487-x0a9qgjs 189 16 effect effect NN cord-281487-x0a9qgjs 189 17 against against IN cord-281487-x0a9qgjs 189 18 acute acute JJ cord-281487-x0a9qgjs 189 19 respiratory respiratory JJ cord-281487-x0a9qgjs 189 20 tract tract NN cord-281487-x0a9qgjs 189 21 infection infection NN cord-281487-x0a9qgjs 189 22 and and CC cord-281487-x0a9qgjs 189 23 with with IN cord-281487-x0a9qgjs 189 24 even even RB cord-281487-x0a9qgjs 189 25 further further JJ cord-281487-x0a9qgjs 189 26 risk risk NN cord-281487-x0a9qgjs 189 27 in in IN cord-281487-x0a9qgjs 189 28 subjects subject NNS cord-281487-x0a9qgjs 189 29 who who WP cord-281487-x0a9qgjs 189 30 concentrations concentration NNS cord-281487-x0a9qgjs 189 31 of of IN cord-281487-x0a9qgjs 189 32 25-hydroxyvitamin 25-hydroxyvitamin CD cord-281487-x0a9qgjs 189 33 D d NN cord-281487-x0a9qgjs 189 34 ( ( -LRB- cord-281487-x0a9qgjs 189 35 25[OH]D 25[oh]d CD cord-281487-x0a9qgjs 189 36 ) ) -RRB- cord-281487-x0a9qgjs 189 37 below below IN cord-281487-x0a9qgjs 189 38 37.5 37.5 CD cord-281487-x0a9qgjs 189 39 nmol nmol NNP cord-281487-x0a9qgjs 189 40 / / SYM cord-281487-x0a9qgjs 189 41 L L NNP cord-281487-x0a9qgjs 189 42 [ [ -LRB- cord-281487-x0a9qgjs 189 43 86 86 CD cord-281487-x0a9qgjs 189 44 ] ] -RRB- cord-281487-x0a9qgjs 189 45 . . . cord-281487-x0a9qgjs 190 1 In in IN cord-281487-x0a9qgjs 190 2 these these DT cord-281487-x0a9qgjs 190 3 studies study NNS cord-281487-x0a9qgjs 190 4 , , , cord-281487-x0a9qgjs 190 5 once once IN cord-281487-x0a9qgjs 190 6 daily daily RB cord-281487-x0a9qgjs 190 7 dosing dose VBG cord-281487-x0a9qgjs 190 8 at at IN cord-281487-x0a9qgjs 190 9 modest modest JJ cord-281487-x0a9qgjs 190 10 doses dose NNS cord-281487-x0a9qgjs 190 11 ( ( -LRB- cord-281487-x0a9qgjs 190 12 400 400 CD cord-281487-x0a9qgjs 190 13 - - SYM cord-281487-x0a9qgjs 190 14 4000 4000 CD cord-281487-x0a9qgjs 190 15 IU IU NNP cord-281487-x0a9qgjs 190 16 / / SYM cord-281487-x0a9qgjs 190 17 day day NN cord-281487-x0a9qgjs 190 18 ) ) -RRB- cord-281487-x0a9qgjs 190 19 appeared appear VBD cord-281487-x0a9qgjs 190 20 to to TO cord-281487-x0a9qgjs 190 21 confer confer VB cord-281487-x0a9qgjs 190 22 benefit benefit NN cord-281487-x0a9qgjs 190 23 , , , cord-281487-x0a9qgjs 190 24 particularly particularly RB cord-281487-x0a9qgjs 190 25 when when WRB cord-281487-x0a9qgjs 190 26 Vitamin vitamin NN cord-281487-x0a9qgjs 190 27 D d NN cord-281487-x0a9qgjs 190 28 levels level NNS cord-281487-x0a9qgjs 190 29 were be VBD cord-281487-x0a9qgjs 190 30 low low JJ cord-281487-x0a9qgjs 190 31 . . . cord-281487-x0a9qgjs 191 1 The the DT cord-281487-x0a9qgjs 191 2 prevalence prevalence NN cord-281487-x0a9qgjs 191 3 of of IN cord-281487-x0a9qgjs 191 4 vitamin vitamin NN cord-281487-x0a9qgjs 191 5 D d NN cord-281487-x0a9qgjs 191 6 deficiency deficiency NN cord-281487-x0a9qgjs 191 7 is be VBZ cord-281487-x0a9qgjs 191 8 40−70 40−70 CD cord-281487-x0a9qgjs 191 9 % % NN cord-281487-x0a9qgjs 191 10 in in IN cord-281487-x0a9qgjs 191 11 the the DT cord-281487-x0a9qgjs 191 12 intensive intensive JJ cord-281487-x0a9qgjs 191 13 care care NN cord-281487-x0a9qgjs 191 14 unit unit NN cord-281487-x0a9qgjs 191 15 and and CC cord-281487-x0a9qgjs 191 16 circulating circulate VBG cord-281487-x0a9qgjs 191 17 25(OH)D 25(oh)d CD cord-281487-x0a9qgjs 191 18 concentrations concentration NNS cord-281487-x0a9qgjs 191 19 may may MD cord-281487-x0a9qgjs 191 20 drop drop VB cord-281487-x0a9qgjs 191 21 rapidly rapidly RB cord-281487-x0a9qgjs 191 22 in in IN cord-281487-x0a9qgjs 191 23 the the DT cord-281487-x0a9qgjs 191 24 early early JJ cord-281487-x0a9qgjs 191 25 illness illness NN cord-281487-x0a9qgjs 191 26 [ [ -LRB- cord-281487-x0a9qgjs 191 27 87 87 CD cord-281487-x0a9qgjs 191 28 ] ] -RRB- cord-281487-x0a9qgjs 191 29 . . . cord-281487-x0a9qgjs 192 1 However however RB cord-281487-x0a9qgjs 192 2 , , , cord-281487-x0a9qgjs 192 3 in in IN cord-281487-x0a9qgjs 192 4 multi multi JJ cord-281487-x0a9qgjs 192 5 - - JJ cord-281487-x0a9qgjs 192 6 center center JJ cord-281487-x0a9qgjs 192 7 RCTs rct NNS cord-281487-x0a9qgjs 192 8 of of IN cord-281487-x0a9qgjs 192 9 critically critically RB cord-281487-x0a9qgjs 192 10 ill ill JJ cord-281487-x0a9qgjs 192 11 patients patient NNS cord-281487-x0a9qgjs 192 12 , , , cord-281487-x0a9qgjs 192 13 a a DT cord-281487-x0a9qgjs 192 14 single single JJ cord-281487-x0a9qgjs 192 15 dose dose NN cord-281487-x0a9qgjs 192 16 of of IN cord-281487-x0a9qgjs 192 17 540,000 540,000 CD cord-281487-x0a9qgjs 192 18 IU IU NNP cord-281487-x0a9qgjs 192 19 or or CC cord-281487-x0a9qgjs 192 20 short short JJ cord-281487-x0a9qgjs 192 21 term term NN cord-281487-x0a9qgjs 192 22 therapy therapy NN cord-281487-x0a9qgjs 192 23 ( ( -LRB- cord-281487-x0a9qgjs 192 24 50,000 50,000 CD cord-281487-x0a9qgjs 192 25 IU IU NNP cord-281487-x0a9qgjs 192 26 or or CC cord-281487-x0a9qgjs 192 27 100,000 100,000 CD cord-281487-x0a9qgjs 192 28 IU IU NNP cord-281487-x0a9qgjs 192 29 for for IN cord-281487-x0a9qgjs 192 30 5 5 CD cord-281487-x0a9qgjs 192 31 days day NNS cord-281487-x0a9qgjs 192 32 ) ) -RRB- cord-281487-x0a9qgjs 192 33 did do VBD cord-281487-x0a9qgjs 192 34 not not RB cord-281487-x0a9qgjs 192 35 show show VB cord-281487-x0a9qgjs 192 36 mortality mortality NN cord-281487-x0a9qgjs 192 37 benefit benefit NN cord-281487-x0a9qgjs 192 38 [ [ -LRB- cord-281487-x0a9qgjs 192 39 88 88 CD cord-281487-x0a9qgjs 192 40 , , , cord-281487-x0a9qgjs 192 41 89 89 CD cord-281487-x0a9qgjs 192 42 ] ] -RRB- cord-281487-x0a9qgjs 192 43 . . . cord-281487-x0a9qgjs 193 1 As as IN cord-281487-x0a9qgjs 193 2 the the DT cord-281487-x0a9qgjs 193 3 relationship relationship NN cord-281487-x0a9qgjs 193 4 between between IN cord-281487-x0a9qgjs 193 5 vitamin vitamin NN cord-281487-x0a9qgjs 193 6 D d NN cord-281487-x0a9qgjs 193 7 supplementation supplementation NN cord-281487-x0a9qgjs 193 8 and and CC cord-281487-x0a9qgjs 193 9 improvement improvement NN cord-281487-x0a9qgjs 193 10 in in IN cord-281487-x0a9qgjs 193 11 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 193 12 outcomes outcome NNS cord-281487-x0a9qgjs 193 13 has have VBZ cord-281487-x0a9qgjs 193 14 not not RB cord-281487-x0a9qgjs 193 15 yet yet RB cord-281487-x0a9qgjs 193 16 been be VBN cord-281487-x0a9qgjs 193 17 established establish VBN cord-281487-x0a9qgjs 193 18 , , , cord-281487-x0a9qgjs 193 19 measurement measurement NN cord-281487-x0a9qgjs 193 20 of of IN cord-281487-x0a9qgjs 193 21 Vitamin vitamin NN cord-281487-x0a9qgjs 193 22 D d NN cord-281487-x0a9qgjs 193 23 levels level NNS cord-281487-x0a9qgjs 193 24 may may MD cord-281487-x0a9qgjs 193 25 be be VB cord-281487-x0a9qgjs 193 26 a a DT cord-281487-x0a9qgjs 193 27 reasonable reasonable JJ cord-281487-x0a9qgjs 193 28 strategy strategy NN cord-281487-x0a9qgjs 193 29 to to TO cord-281487-x0a9qgjs 193 30 guide guide VB cord-281487-x0a9qgjs 193 31 supplementation supplementation NN cord-281487-x0a9qgjs 193 32 using use VBG cord-281487-x0a9qgjs 193 33 modest modest JJ cord-281487-x0a9qgjs 193 34 daily daily JJ cord-281487-x0a9qgjs 193 35 dosing dosing NN cord-281487-x0a9qgjs 193 36 until until IN cord-281487-x0a9qgjs 193 37 further further JJ cord-281487-x0a9qgjs 193 38 data data NN cord-281487-x0a9qgjs 193 39 is be VBZ cord-281487-x0a9qgjs 193 40 available available JJ cord-281487-x0a9qgjs 193 41 . . . cord-281487-x0a9qgjs 194 1 In in IN cord-281487-x0a9qgjs 194 2 KT KT NNP cord-281487-x0a9qgjs 194 3 recipients recipient NNS cord-281487-x0a9qgjs 194 4 , , , cord-281487-x0a9qgjs 194 5 we -PRON- PRP cord-281487-x0a9qgjs 194 6 routinely routinely RB cord-281487-x0a9qgjs 194 7 give give VBP cord-281487-x0a9qgjs 194 8 ergocalciferol ergocalciferol JJ cord-281487-x0a9qgjs 194 9 50,000 50,000 CD cord-281487-x0a9qgjs 194 10 units unit NNS cord-281487-x0a9qgjs 194 11 orally orally RB cord-281487-x0a9qgjs 194 12 daily daily RB cord-281487-x0a9qgjs 194 13 for for IN cord-281487-x0a9qgjs 194 14 5 5 CD cord-281487-x0a9qgjs 194 15 days day NNS cord-281487-x0a9qgjs 194 16 at at IN cord-281487-x0a9qgjs 194 17 the the DT cord-281487-x0a9qgjs 194 18 time time NN cord-281487-x0a9qgjs 194 19 of of IN cord-281487-x0a9qgjs 194 20 transplant transplant NN cord-281487-x0a9qgjs 194 21 and and CC cord-281487-x0a9qgjs 194 22 upon upon IN cord-281487-x0a9qgjs 194 23 a a DT cord-281487-x0a9qgjs 194 24 positive positive JJ cord-281487-x0a9qgjs 194 25 COVID-19 COVID-19 , cord-281487-x0a9qgjs 194 26 PCR PCR NNP cord-281487-x0a9qgjs 194 27 . . . cord-281487-x0a9qgjs 195 1 Melatonin melatonin NN cord-281487-x0a9qgjs 195 2 lowers lower VBZ cord-281487-x0a9qgjs 195 3 the the DT cord-281487-x0a9qgjs 195 4 levels level NNS cord-281487-x0a9qgjs 195 5 of of IN cord-281487-x0a9qgjs 195 6 circulating circulate VBG cord-281487-x0a9qgjs 195 7 cytokines cytokine NNS cord-281487-x0a9qgjs 195 8 and and CC cord-281487-x0a9qgjs 195 9 may may MD cord-281487-x0a9qgjs 195 10 reduce reduce VB cord-281487-x0a9qgjs 195 11 pro pro JJ cord-281487-x0a9qgjs 195 12 - - JJ cord-281487-x0a9qgjs 195 13 inflammatory inflammatory JJ cord-281487-x0a9qgjs 195 14 cytokine cytokine NN cord-281487-x0a9qgjs 195 15 levels level NNS cord-281487-x0a9qgjs 195 16 in in IN cord-281487-x0a9qgjs 195 17 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 195 18 patients patient NNS cord-281487-x0a9qgjs 195 19 [ [ -LRB- cord-281487-x0a9qgjs 195 20 60 60 CD cord-281487-x0a9qgjs 195 21 ] ] -RRB- cord-281487-x0a9qgjs 195 22 . . . cord-281487-x0a9qgjs 196 1 Further further RB cord-281487-x0a9qgjs 196 2 , , , cord-281487-x0a9qgjs 196 3 stress stress NN cord-281487-x0a9qgjs 196 4 and and CC cord-281487-x0a9qgjs 196 5 sleep sleep NN cord-281487-x0a9qgjs 196 6 deprivation deprivation NN cord-281487-x0a9qgjs 196 7 induce induce VBP cord-281487-x0a9qgjs 196 8 immunosuppression immunosuppression NN cord-281487-x0a9qgjs 196 9 . . . cord-281487-x0a9qgjs 197 1 These these DT cord-281487-x0a9qgjs 197 2 negative negative JJ cord-281487-x0a9qgjs 197 3 effects effect NNS cord-281487-x0a9qgjs 197 4 on on IN cord-281487-x0a9qgjs 197 5 immunity immunity NN cord-281487-x0a9qgjs 197 6 may may MD cord-281487-x0a9qgjs 197 7 be be VB cord-281487-x0a9qgjs 197 8 alleviated alleviate VBN cord-281487-x0a9qgjs 197 9 by by IN cord-281487-x0a9qgjs 197 10 restoring restore VBG cord-281487-x0a9qgjs 197 11 sleep sleep NN cord-281487-x0a9qgjs 197 12 disorder disorder NN cord-281487-x0a9qgjs 197 13 and and CC cord-281487-x0a9qgjs 197 14 reducing reduce VBG cord-281487-x0a9qgjs 197 15 anxiety anxiety NN cord-281487-x0a9qgjs 197 16 through through IN cord-281487-x0a9qgjs 197 17 melatonin melatonin NN cord-281487-x0a9qgjs 197 18 [ [ -LRB- cord-281487-x0a9qgjs 197 19 90 90 CD cord-281487-x0a9qgjs 197 20 ] ] -RRB- cord-281487-x0a9qgjs 197 21 . . . cord-281487-x0a9qgjs 198 1 So so RB cord-281487-x0a9qgjs 198 2 far far RB cord-281487-x0a9qgjs 198 3 , , , cord-281487-x0a9qgjs 198 4 the the DT cord-281487-x0a9qgjs 198 5 direct direct JJ cord-281487-x0a9qgjs 198 6 evidence evidence NN cord-281487-x0a9qgjs 198 7 of of IN cord-281487-x0a9qgjs 198 8 melatonin melatonin NN cord-281487-x0a9qgjs 198 9 application application NN cord-281487-x0a9qgjs 198 10 in in IN cord-281487-x0a9qgjs 198 11 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 198 12 is be VBZ cord-281487-x0a9qgjs 198 13 unclear unclear JJ cord-281487-x0a9qgjs 198 14 . . . cord-281487-x0a9qgjs 199 1 Further further JJ cord-281487-x0a9qgjs 199 2 research research NN cord-281487-x0a9qgjs 199 3 is be VBZ cord-281487-x0a9qgjs 199 4 needed need VBN cord-281487-x0a9qgjs 199 5 to to TO cord-281487-x0a9qgjs 199 6 determine determine VB cord-281487-x0a9qgjs 199 7 if if IN cord-281487-x0a9qgjs 199 8 it -PRON- PRP cord-281487-x0a9qgjs 199 9 has have VBZ cord-281487-x0a9qgjs 199 10 a a DT cord-281487-x0a9qgjs 199 11 COVID covid JJ cord-281487-x0a9qgjs 199 12 specific specific JJ cord-281487-x0a9qgjs 199 13 application application NN cord-281487-x0a9qgjs 199 14 outside outside IN cord-281487-x0a9qgjs 199 15 of of IN cord-281487-x0a9qgjs 199 16 generalized generalized JJ cord-281487-x0a9qgjs 199 17 sleep sleep NN cord-281487-x0a9qgjs 199 18 and and CC cord-281487-x0a9qgjs 199 19 anxiety anxiety NN cord-281487-x0a9qgjs 199 20 disorders disorder NNS cord-281487-x0a9qgjs 199 21 . . . cord-281487-x0a9qgjs 200 1 Cytokine cytokine NN cord-281487-x0a9qgjs 200 2 release release NN cord-281487-x0a9qgjs 200 3 syndrome syndrome NN cord-281487-x0a9qgjs 200 4 ( ( -LRB- cord-281487-x0a9qgjs 200 5 CRS CRS NNP cord-281487-x0a9qgjs 200 6 ) ) -RRB- cord-281487-x0a9qgjs 200 7 , , , cord-281487-x0a9qgjs 200 8 characterized characterize VBN cord-281487-x0a9qgjs 200 9 by by IN cord-281487-x0a9qgjs 200 10 a a DT cord-281487-x0a9qgjs 200 11 systemic systemic JJ cord-281487-x0a9qgjs 200 12 inflammatory inflammatory JJ cord-281487-x0a9qgjs 200 13 response response NN cord-281487-x0a9qgjs 200 14 resulting result VBG cord-281487-x0a9qgjs 200 15 from from IN cord-281487-x0a9qgjs 200 16 the the DT cord-281487-x0a9qgjs 200 17 release release NN cord-281487-x0a9qgjs 200 18 of of IN cord-281487-x0a9qgjs 200 19 inflammatory inflammatory JJ cord-281487-x0a9qgjs 200 20 cytokines cytokine NNS cord-281487-x0a9qgjs 200 21 including include VBG cord-281487-x0a9qgjs 200 22 IL-6 IL-6 NNP cord-281487-x0a9qgjs 200 23 , , , cord-281487-x0a9qgjs 200 24 is be VBZ cord-281487-x0a9qgjs 200 25 a a DT cord-281487-x0a9qgjs 200 26 hallmark hallmark NN cord-281487-x0a9qgjs 200 27 of of IN cord-281487-x0a9qgjs 200 28 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 200 29 progression progression NN cord-281487-x0a9qgjs 200 30 [ [ -LRB- cord-281487-x0a9qgjs 200 31 91 91 CD cord-281487-x0a9qgjs 200 32 ] ] -RRB- cord-281487-x0a9qgjs 200 33 . . . cord-281487-x0a9qgjs 201 1 Although although IN cord-281487-x0a9qgjs 201 2 immunomodulatory immunomodulatory JJ cord-281487-x0a9qgjs 201 3 therapy therapy NN cord-281487-x0a9qgjs 201 4 is be VBZ cord-281487-x0a9qgjs 201 5 discussed discuss VBN cord-281487-x0a9qgjs 201 6 separately separately RB cord-281487-x0a9qgjs 201 7 , , , cord-281487-x0a9qgjs 201 8 we -PRON- PRP cord-281487-x0a9qgjs 201 9 note note VBP cord-281487-x0a9qgjs 201 10 that that IN cord-281487-x0a9qgjs 201 11 blocking blocking NN cord-281487-x0a9qgjs 201 12 of of IN cord-281487-x0a9qgjs 201 13 the the DT cord-281487-x0a9qgjs 201 14 catecholamine catecholamine NN cord-281487-x0a9qgjs 201 15 pathway pathway NN cord-281487-x0a9qgjs 201 16 with with IN cord-281487-x0a9qgjs 201 17 alpha-1 alpha-1 JJ cord-281487-x0a9qgjs 201 18 adrenergic adrenergic JJ cord-281487-x0a9qgjs 201 19 receptor receptor NN cord-281487-x0a9qgjs 201 20 antagonists antagonist NNS cord-281487-x0a9qgjs 201 21 ( ( -LRB- cord-281487-x0a9qgjs 201 22 ⍺ ⍺ VBZ cord-281487-x0a9qgjs 201 23 -blockers -blocker NNS cord-281487-x0a9qgjs 201 24 ) ) -RRB- cord-281487-x0a9qgjs 201 25 may may MD cord-281487-x0a9qgjs 201 26 reduce reduce VB cord-281487-x0a9qgjs 201 27 cytokine cytokine NN cord-281487-x0a9qgjs 201 28 storms storm NNS cord-281487-x0a9qgjs 201 29 [ [ -LRB- cord-281487-x0a9qgjs 201 30 92 92 CD cord-281487-x0a9qgjs 201 31 ] ] -RRB- cord-281487-x0a9qgjs 201 32 . . . cord-281487-x0a9qgjs 202 1 In in IN cord-281487-x0a9qgjs 202 2 a a DT cord-281487-x0a9qgjs 202 3 retrospective retrospective JJ cord-281487-x0a9qgjs 202 4 study study NN cord-281487-x0a9qgjs 202 5 , , , cord-281487-x0a9qgjs 202 6 Vogelstein Vogelstein NNP cord-281487-x0a9qgjs 202 7 et et NNP cord-281487-x0a9qgjs 202 8 al al NNP cord-281487-x0a9qgjs 202 9 . . . cord-281487-x0a9qgjs 203 1 found find VBD cord-281487-x0a9qgjs 203 2 that that IN cord-281487-x0a9qgjs 203 3 the the DT cord-281487-x0a9qgjs 203 4 use use NN cord-281487-x0a9qgjs 203 5 of of IN cord-281487-x0a9qgjs 203 6 αblockers αblocker NNS cord-281487-x0a9qgjs 203 7 was be VBD cord-281487-x0a9qgjs 203 8 associated associate VBN cord-281487-x0a9qgjs 203 9 with with IN cord-281487-x0a9qgjs 203 10 reduced reduce VBN cord-281487-x0a9qgjs 203 11 ARDS ARDS NNP cord-281487-x0a9qgjs 203 12 and and CC cord-281487-x0a9qgjs 203 13 death death NN cord-281487-x0a9qgjs 203 14 from from IN cord-281487-x0a9qgjs 203 15 CRS CRS NNP cord-281487-x0a9qgjs 203 16 [ [ -LRB- cord-281487-x0a9qgjs 203 17 93 93 CD cord-281487-x0a9qgjs 203 18 ] ] -RRB- cord-281487-x0a9qgjs 203 19 . . . cord-281487-x0a9qgjs 204 1 As as IN cord-281487-x0a9qgjs 204 2 such such JJ cord-281487-x0a9qgjs 204 3 , , , cord-281487-x0a9qgjs 204 4 prospective prospective JJ cord-281487-x0a9qgjs 204 5 clinical clinical JJ cord-281487-x0a9qgjs 204 6 trials trial NNS cord-281487-x0a9qgjs 204 7 are be VBP cord-281487-x0a9qgjs 204 8 underway underway JJ cord-281487-x0a9qgjs 204 9 to to TO cord-281487-x0a9qgjs 204 10 determine determine VB cord-281487-x0a9qgjs 204 11 whether whether IN cord-281487-x0a9qgjs 204 12 these these DT cord-281487-x0a9qgjs 204 13 agents agent NNS cord-281487-x0a9qgjs 204 14 can can MD cord-281487-x0a9qgjs 204 15 pre pre VB cord-281487-x0a9qgjs 204 16 - - VB cord-281487-x0a9qgjs 204 17 emptively emptively RB cord-281487-x0a9qgjs 204 18 reduce reduce VB cord-281487-x0a9qgjs 204 19 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 204 20 disease disease NN cord-281487-x0a9qgjs 204 21 progression progression NN cord-281487-x0a9qgjs 204 22 [ [ -LRB- cord-281487-x0a9qgjs 204 23 94 94 CD cord-281487-x0a9qgjs 204 24 ] ] -RRB- cord-281487-x0a9qgjs 204 25 . . . cord-281487-x0a9qgjs 205 1 Patients patient NNS cord-281487-x0a9qgjs 205 2 can can MD cord-281487-x0a9qgjs 205 3 be be VB cord-281487-x0a9qgjs 205 4 discharged discharge VBN cord-281487-x0a9qgjs 205 5 from from IN cord-281487-x0a9qgjs 205 6 the the DT cord-281487-x0a9qgjs 205 7 hospital hospital NN cord-281487-x0a9qgjs 205 8 when when WRB cord-281487-x0a9qgjs 205 9 clinically clinically RB cord-281487-x0a9qgjs 205 10 indicated indicate VBN cord-281487-x0a9qgjs 205 11 . . . cord-281487-x0a9qgjs 206 1 Isolation isolation NN cord-281487-x0a9qgjs 206 2 should should MD cord-281487-x0a9qgjs 206 3 be be VB cord-281487-x0a9qgjs 206 4 maintained maintain VBN cord-281487-x0a9qgjs 206 5 if if IN cord-281487-x0a9qgjs 206 6 the the DT cord-281487-x0a9qgjs 206 7 patients patient NNS cord-281487-x0a9qgjs 206 8 are be VBP cord-281487-x0a9qgjs 206 9 discharged discharge VBN cord-281487-x0a9qgjs 206 10 to to IN cord-281487-x0a9qgjs 206 11 home home NN cord-281487-x0a9qgjs 206 12 or or CC cord-281487-x0a9qgjs 206 13 long long JJ cord-281487-x0a9qgjs 206 14 - - HYPH cord-281487-x0a9qgjs 206 15 term term NN cord-281487-x0a9qgjs 206 16 care care NN cord-281487-x0a9qgjs 206 17 facility facility NN cord-281487-x0a9qgjs 206 18 before before IN cord-281487-x0a9qgjs 206 19 discontinuation discontinuation NN cord-281487-x0a9qgjs 206 20 of of IN cord-281487-x0a9qgjs 206 21 isolation isolation NN cord-281487-x0a9qgjs 206 22 and and CC cord-281487-x0a9qgjs 206 23 may may MD cord-281487-x0a9qgjs 206 24 pose pose VB cord-281487-x0a9qgjs 206 25 a a DT cord-281487-x0a9qgjs 206 26 challenge challenge NN cord-281487-x0a9qgjs 206 27 in in IN cord-281487-x0a9qgjs 206 28 a a DT cord-281487-x0a9qgjs 206 29 safe safe JJ cord-281487-x0a9qgjs 206 30 return return NN cord-281487-x0a9qgjs 206 31 to to IN cord-281487-x0a9qgjs 206 32 a a DT cord-281487-x0a9qgjs 206 33 home home NN cord-281487-x0a9qgjs 206 34 environment environment NN cord-281487-x0a9qgjs 206 35 if if IN cord-281487-x0a9qgjs 206 36 there there EX cord-281487-x0a9qgjs 206 37 are be VBP cord-281487-x0a9qgjs 206 38 uninfected uninfected JJ cord-281487-x0a9qgjs 206 39 individuals individual NNS cord-281487-x0a9qgjs 206 40 in in IN cord-281487-x0a9qgjs 206 41 the the DT cord-281487-x0a9qgjs 206 42 home home NN cord-281487-x0a9qgjs 206 43 . . . cord-281487-x0a9qgjs 207 1 Long long JJ cord-281487-x0a9qgjs 207 2 - - HYPH cord-281487-x0a9qgjs 207 3 term term NN cord-281487-x0a9qgjs 207 4 care care NN cord-281487-x0a9qgjs 207 5 facilities facility NNS cord-281487-x0a9qgjs 207 6 should should MD cord-281487-x0a9qgjs 207 7 follow follow VB cord-281487-x0a9qgjs 207 8 infection infection NN cord-281487-x0a9qgjs 207 9 prevention prevention NN cord-281487-x0a9qgjs 207 10 and and CC cord-281487-x0a9qgjs 207 11 control control NN cord-281487-x0a9qgjs 207 12 recommendations recommendation NNS cord-281487-x0a9qgjs 207 13 for for IN cord-281487-x0a9qgjs 207 14 the the DT cord-281487-x0a9qgjs 207 15 care care NN cord-281487-x0a9qgjs 207 16 of of IN cord-281487-x0a9qgjs 207 17 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 207 18 patients patient NNS cord-281487-x0a9qgjs 207 19 [ [ -LRB- cord-281487-x0a9qgjs 207 20 52 52 CD cord-281487-x0a9qgjs 207 21 ] ] -RRB- cord-281487-x0a9qgjs 207 22 . . . cord-281487-x0a9qgjs 208 1 As as IN cord-281487-x0a9qgjs 208 2 there there EX cord-281487-x0a9qgjs 208 3 is be VBZ cord-281487-x0a9qgjs 208 4 a a DT cord-281487-x0a9qgjs 208 5 paucity paucity NN cord-281487-x0a9qgjs 208 6 of of IN cord-281487-x0a9qgjs 208 7 high high JJ cord-281487-x0a9qgjs 208 8 - - HYPH cord-281487-x0a9qgjs 208 9 quality quality NN cord-281487-x0a9qgjs 208 10 evidence evidence NN cord-281487-x0a9qgjs 208 11 to to TO cord-281487-x0a9qgjs 208 12 guide guide VB cord-281487-x0a9qgjs 208 13 management management NN cord-281487-x0a9qgjs 208 14 of of IN cord-281487-x0a9qgjs 208 15 the the DT cord-281487-x0a9qgjs 208 16 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 208 17 infected infected JJ cord-281487-x0a9qgjs 208 18 transplant transplant NN cord-281487-x0a9qgjs 208 19 recipient recipient NN cord-281487-x0a9qgjs 208 20 , , , cord-281487-x0a9qgjs 208 21 many many JJ cord-281487-x0a9qgjs 208 22 centers center NNS cord-281487-x0a9qgjs 208 23 have have VBP cord-281487-x0a9qgjs 208 24 implemented implement VBN cord-281487-x0a9qgjs 208 25 practices practice NNS cord-281487-x0a9qgjs 208 26 based base VBN cord-281487-x0a9qgjs 208 27 on on IN cord-281487-x0a9qgjs 208 28 biological biological JJ cord-281487-x0a9qgjs 208 29 plausibility plausibility NN cord-281487-x0a9qgjs 208 30 and and CC cord-281487-x0a9qgjs 208 31 extrapolation extrapolation NN cord-281487-x0a9qgjs 208 32 from from IN cord-281487-x0a9qgjs 208 33 scenarios scenario NNS cord-281487-x0a9qgjs 208 34 which which WDT cord-281487-x0a9qgjs 208 35 share share VBP cord-281487-x0a9qgjs 208 36 common common JJ cord-281487-x0a9qgjs 208 37 features feature NNS cord-281487-x0a9qgjs 208 38 with with IN cord-281487-x0a9qgjs 208 39 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 208 40 . . . cord-281487-x0a9qgjs 209 1 At at IN cord-281487-x0a9qgjs 209 2 our -PRON- PRP$ cord-281487-x0a9qgjs 209 3 institution institution NN cord-281487-x0a9qgjs 209 4 , , , cord-281487-x0a9qgjs 209 5 we -PRON- PRP cord-281487-x0a9qgjs 209 6 have have VBP cord-281487-x0a9qgjs 209 7 noted note VBN cord-281487-x0a9qgjs 209 8 markedly markedly RB cord-281487-x0a9qgjs 209 9 low low JJ cord-281487-x0a9qgjs 209 10 mortality mortality NN cord-281487-x0a9qgjs 209 11 of of IN cord-281487-x0a9qgjs 209 12 3.7 3.7 CD cord-281487-x0a9qgjs 209 13 % % NN cord-281487-x0a9qgjs 209 14 in in IN cord-281487-x0a9qgjs 209 15 the the DT cord-281487-x0a9qgjs 209 16 1st 1st JJ cord-281487-x0a9qgjs 209 17 27 27 CD cord-281487-x0a9qgjs 209 18 solid solid JJ cord-281487-x0a9qgjs 209 19 organ organ NN cord-281487-x0a9qgjs 209 20 transplant transplant NN cord-281487-x0a9qgjs 209 21 recipients recipient NNS cord-281487-x0a9qgjs 209 22 cared care VBN cord-281487-x0a9qgjs 209 23 by by IN cord-281487-x0a9qgjs 209 24 our -PRON- PRP$ cord-281487-x0a9qgjs 209 25 providers provider NNS cord-281487-x0a9qgjs 209 26 between between IN cord-281487-x0a9qgjs 209 27 March March NNP cord-281487-x0a9qgjs 209 28 15 15 CD cord-281487-x0a9qgjs 209 29 , , , cord-281487-x0a9qgjs 209 30 2020 2020 CD cord-281487-x0a9qgjs 209 31 and and CC cord-281487-x0a9qgjs 209 32 May May NNP cord-281487-x0a9qgjs 209 33 22 22 CD cord-281487-x0a9qgjs 209 34 , , , cord-281487-x0a9qgjs 209 35 2020 2020 CD cord-281487-x0a9qgjs 209 36 , , , cord-281487-x0a9qgjs 209 37 compared compare VBN cord-281487-x0a9qgjs 209 38 to to IN cord-281487-x0a9qgjs 209 39 reports report NNS cord-281487-x0a9qgjs 209 40 from from IN cord-281487-x0a9qgjs 209 41 other other JJ cord-281487-x0a9qgjs 209 42 institutions institution NNS cord-281487-x0a9qgjs 209 43 in in IN cord-281487-x0a9qgjs 209 44 similar similar JJ cord-281487-x0a9qgjs 209 45 time time NN cord-281487-x0a9qgjs 209 46 periods period NNS cord-281487-x0a9qgjs 209 47 ( ( -LRB- cord-281487-x0a9qgjs 209 48 Table table NN cord-281487-x0a9qgjs 209 49 2 2 CD cord-281487-x0a9qgjs 209 50 ) ) -RRB- cord-281487-x0a9qgjs 209 51 . . . cord-281487-x0a9qgjs 210 1 While while IN cord-281487-x0a9qgjs 210 2 we -PRON- PRP cord-281487-x0a9qgjs 210 3 can can MD cord-281487-x0a9qgjs 210 4 not not RB cord-281487-x0a9qgjs 210 5 yet yet RB cord-281487-x0a9qgjs 210 6 definitely definitely RB cord-281487-x0a9qgjs 210 7 determine determine VB cord-281487-x0a9qgjs 210 8 which which WDT cord-281487-x0a9qgjs 210 9 of of IN cord-281487-x0a9qgjs 210 10 our -PRON- PRP$ cord-281487-x0a9qgjs 210 11 practices practice NNS cord-281487-x0a9qgjs 210 12 contributed contribute VBD cord-281487-x0a9qgjs 210 13 to to IN cord-281487-x0a9qgjs 210 14 this this DT cord-281487-x0a9qgjs 210 15 excellent excellent JJ cord-281487-x0a9qgjs 210 16 outcome outcome NN cord-281487-x0a9qgjs 210 17 , , , cord-281487-x0a9qgjs 210 18 we -PRON- PRP cord-281487-x0a9qgjs 210 19 have have VBP cord-281487-x0a9qgjs 210 20 in in IN cord-281487-x0a9qgjs 210 21 this this DT cord-281487-x0a9qgjs 210 22 section section NN cord-281487-x0a9qgjs 210 23 , , , cord-281487-x0a9qgjs 210 24 detailed detail VBN cord-281487-x0a9qgjs 210 25 our -PRON- PRP$ cord-281487-x0a9qgjs 210 26 center center NN cord-281487-x0a9qgjs 210 27 's 's POS cord-281487-x0a9qgjs 210 28 specific specific JJ cord-281487-x0a9qgjs 210 29 practices practice NNS cord-281487-x0a9qgjs 210 30 ( ( -LRB- cord-281487-x0a9qgjs 210 31 Fig fig NN cord-281487-x0a9qgjs 210 32 . . NNP cord-281487-x0a9qgjs 210 33 1 1 CD cord-281487-x0a9qgjs 210 34 ) ) -RRB- cord-281487-x0a9qgjs 210 35 , , , cord-281487-x0a9qgjs 210 36 and and CC cord-281487-x0a9qgjs 210 37 look look VB cord-281487-x0a9qgjs 210 38 forward forward RB cord-281487-x0a9qgjs 210 39 to to IN cord-281487-x0a9qgjs 210 40 further further JJ cord-281487-x0a9qgjs 210 41 science science NN cord-281487-x0a9qgjs 210 42 to to TO cord-281487-x0a9qgjs 210 43 refine refine VB cord-281487-x0a9qgjs 210 44 these these DT cord-281487-x0a9qgjs 210 45 clinical clinical JJ cord-281487-x0a9qgjs 210 46 algorithms algorithm NNS cord-281487-x0a9qgjs 210 47 . . . cord-281487-x0a9qgjs 211 1 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 211 2 is be VBZ cord-281487-x0a9qgjs 211 3 an an DT cord-281487-x0a9qgjs 211 4 unprecedented unprecedented JJ cord-281487-x0a9qgjs 211 5 worldwide worldwide JJ cord-281487-x0a9qgjs 211 6 challenge challenge NN cord-281487-x0a9qgjs 211 7 , , , cord-281487-x0a9qgjs 211 8 that that RB cord-281487-x0a9qgjs 211 9 is is RB cord-281487-x0a9qgjs 211 10 , , , cord-281487-x0a9qgjs 211 11 heightened heighten VBN cord-281487-x0a9qgjs 211 12 in in IN cord-281487-x0a9qgjs 211 13 solid solid JJ cord-281487-x0a9qgjs 211 14 organ organ NN cord-281487-x0a9qgjs 211 15 transplant transplant NN cord-281487-x0a9qgjs 211 16 recipients recipient NNS cord-281487-x0a9qgjs 211 17 . . . cord-281487-x0a9qgjs 212 1 While while IN cord-281487-x0a9qgjs 212 2 a a DT cord-281487-x0a9qgjs 212 3 worldwide worldwide JJ cord-281487-x0a9qgjs 212 4 effort effort NN cord-281487-x0a9qgjs 212 5 is be VBZ cord-281487-x0a9qgjs 212 6 underway underway JJ cord-281487-x0a9qgjs 212 7 to to TO cord-281487-x0a9qgjs 212 8 identify identify VB cord-281487-x0a9qgjs 212 9 the the DT cord-281487-x0a9qgjs 212 10 best good JJS cord-281487-x0a9qgjs 212 11 therapeutics therapeutic NNS cord-281487-x0a9qgjs 212 12 and and CC cord-281487-x0a9qgjs 212 13 vaccines vaccine NNS cord-281487-x0a9qgjs 212 14 , , , cord-281487-x0a9qgjs 212 15 their -PRON- PRP$ cord-281487-x0a9qgjs 212 16 risk risk NN cord-281487-x0a9qgjs 212 17 and and CC cord-281487-x0a9qgjs 212 18 benefit benefit NN cord-281487-x0a9qgjs 212 19 in in IN cord-281487-x0a9qgjs 212 20 transplant transplant NN cord-281487-x0a9qgjs 212 21 recipients recipient NNS cord-281487-x0a9qgjs 212 22 remain remain VBP cord-281487-x0a9qgjs 212 23 undetermined undetermined JJ cord-281487-x0a9qgjs 212 24 . . . cord-281487-x0a9qgjs 213 1 Thus thus RB cord-281487-x0a9qgjs 213 2 , , , cord-281487-x0a9qgjs 213 3 it -PRON- PRP cord-281487-x0a9qgjs 213 4 is be VBZ cord-281487-x0a9qgjs 213 5 critical critical JJ cord-281487-x0a9qgjs 213 6 to to TO cord-281487-x0a9qgjs 213 7 reinforce reinforce VB cord-281487-x0a9qgjs 213 8 to to IN cord-281487-x0a9qgjs 213 9 transplant transplant NN cord-281487-x0a9qgjs 213 10 households household NNS cord-281487-x0a9qgjs 213 11 to to TO cord-281487-x0a9qgjs 213 12 strictly strictly RB cord-281487-x0a9qgjs 213 13 adhere adhere VB cord-281487-x0a9qgjs 213 14 to to IN cord-281487-x0a9qgjs 213 15 infection infection NN cord-281487-x0a9qgjs 213 16 prevention prevention NN cord-281487-x0a9qgjs 213 17 measures measure NNS cord-281487-x0a9qgjs 213 18 . . . cord-281487-x0a9qgjs 214 1 Transplant transplant NN cord-281487-x0a9qgjs 214 2 recipients recipient NNS cord-281487-x0a9qgjs 214 3 should should MD cord-281487-x0a9qgjs 214 4 remain remain VB cord-281487-x0a9qgjs 214 5 in in IN cord-281487-x0a9qgjs 214 6 close close JJ cord-281487-x0a9qgjs 214 7 communication communication NN cord-281487-x0a9qgjs 214 8 with with IN cord-281487-x0a9qgjs 214 9 their -PRON- PRP$ cord-281487-x0a9qgjs 214 10 health health NN cord-281487-x0a9qgjs 214 11 team team NN cord-281487-x0a9qgjs 214 12 to to TO cord-281487-x0a9qgjs 214 13 monitor monitor VB cord-281487-x0a9qgjs 214 14 their -PRON- PRP$ cord-281487-x0a9qgjs 214 15 overall overall JJ cord-281487-x0a9qgjs 214 16 health health NN cord-281487-x0a9qgjs 214 17 , , , cord-281487-x0a9qgjs 214 18 manage manage VB cord-281487-x0a9qgjs 214 19 comorbidities comorbiditie NNS cord-281487-x0a9qgjs 214 20 and and CC cord-281487-x0a9qgjs 214 21 identify identify VB cord-281487-x0a9qgjs 214 22 any any DT cord-281487-x0a9qgjs 214 23 new new JJ cord-281487-x0a9qgjs 214 24 findings finding NNS cord-281487-x0a9qgjs 214 25 that that WDT cord-281487-x0a9qgjs 214 26 may may MD cord-281487-x0a9qgjs 214 27 confer confer VB cord-281487-x0a9qgjs 214 28 risk risk NN cord-281487-x0a9qgjs 214 29 of of IN cord-281487-x0a9qgjs 214 30 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 214 31 . . . cord-281487-x0a9qgjs 215 1 Finally finally RB cord-281487-x0a9qgjs 215 2 , , , cord-281487-x0a9qgjs 215 3 understanding understanding NN cord-281487-x0a9qgjs 215 4 of of IN cord-281487-x0a9qgjs 215 5 the the DT cord-281487-x0a9qgjs 215 6 transplant transplant NN cord-281487-x0a9qgjs 215 7 specific specific JJ cord-281487-x0a9qgjs 215 8 pathophysiology pathophysiology NN cord-281487-x0a9qgjs 215 9 , , , cord-281487-x0a9qgjs 215 10 effective effective JJ cord-281487-x0a9qgjs 215 11 treatments treatment NNS cord-281487-x0a9qgjs 215 12 , , , cord-281487-x0a9qgjs 215 13 and and CC cord-281487-x0a9qgjs 215 14 adjunctive adjunctive JJ cord-281487-x0a9qgjs 215 15 practices practice NNS cord-281487-x0a9qgjs 215 16 for for IN cord-281487-x0a9qgjs 215 17 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 215 18 should should MD cord-281487-x0a9qgjs 215 19 be be VB cord-281487-x0a9qgjs 215 20 prioritized prioritize VBN cord-281487-x0a9qgjs 215 21 as as IN cord-281487-x0a9qgjs 215 22 part part NN cord-281487-x0a9qgjs 215 23 of of IN cord-281487-x0a9qgjs 215 24 a a DT cord-281487-x0a9qgjs 215 25 comprehensive comprehensive JJ cord-281487-x0a9qgjs 215 26 research research NN cord-281487-x0a9qgjs 215 27 strategy strategy NN cord-281487-x0a9qgjs 215 28 to to TO cord-281487-x0a9qgjs 215 29 optimize optimize VB cord-281487-x0a9qgjs 215 30 outcomes outcome NNS cord-281487-x0a9qgjs 215 31 . . . cord-281487-x0a9qgjs 216 1 Global global JJ cord-281487-x0a9qgjs 216 2 transplantation transplantation NN cord-281487-x0a9qgjs 216 3 COVID COVID NNP cord-281487-x0a9qgjs 216 4 report report NN cord-281487-x0a9qgjs 216 5 Early early JJ cord-281487-x0a9qgjs 216 6 impact impact NN cord-281487-x0a9qgjs 216 7 of of IN cord-281487-x0a9qgjs 216 8 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 216 9 on on IN cord-281487-x0a9qgjs 216 10 transplant transplant NN cord-281487-x0a9qgjs 216 11 center center NN cord-281487-x0a9qgjs 216 12 practices practice NNS cord-281487-x0a9qgjs 216 13 and and CC cord-281487-x0a9qgjs 216 14 policies policy NNS cord-281487-x0a9qgjs 216 15 in in IN cord-281487-x0a9qgjs 216 16 the the DT cord-281487-x0a9qgjs 216 17 United United NNP cord-281487-x0a9qgjs 216 18 States States NNP cord-281487-x0a9qgjs 217 1 The the DT cord-281487-x0a9qgjs 217 2 impact impact NN cord-281487-x0a9qgjs 217 3 of of IN cord-281487-x0a9qgjs 217 4 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 217 5 on on IN cord-281487-x0a9qgjs 217 6 the the DT cord-281487-x0a9qgjs 217 7 state state NN cord-281487-x0a9qgjs 217 8 of of IN cord-281487-x0a9qgjs 217 9 clinical clinical JJ cord-281487-x0a9qgjs 217 10 and and CC cord-281487-x0a9qgjs 217 11 laboratory laboratory NN cord-281487-x0a9qgjs 217 12 research research NN cord-281487-x0a9qgjs 217 13 globally globally RB cord-281487-x0a9qgjs 217 14 in in IN cord-281487-x0a9qgjs 217 15 transplantation transplantation NN cord-281487-x0a9qgjs 217 16 in in IN cord-281487-x0a9qgjs 217 17 Kidney kidney NN cord-281487-x0a9qgjs 217 18 diseases disease NNS cord-281487-x0a9qgjs 217 19 in in IN cord-281487-x0a9qgjs 217 20 the the DT cord-281487-x0a9qgjs 217 21 time time NN cord-281487-x0a9qgjs 217 22 of of IN cord-281487-x0a9qgjs 217 23 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 217 24 : : : cord-281487-x0a9qgjs 217 25 major major JJ cord-281487-x0a9qgjs 217 26 challenges challenge NNS cord-281487-x0a9qgjs 217 27 to to TO cord-281487-x0a9qgjs 217 28 patient patient NN cord-281487-x0a9qgjs 217 29 care care NN cord-281487-x0a9qgjs 217 30 Identifying identify VBG cord-281487-x0a9qgjs 217 31 scenarios scenario NNS cord-281487-x0a9qgjs 217 32 of of IN cord-281487-x0a9qgjs 217 33 benefit benefit NN cord-281487-x0a9qgjs 217 34 or or CC cord-281487-x0a9qgjs 217 35 harm harm NN cord-281487-x0a9qgjs 217 36 from from IN cord-281487-x0a9qgjs 217 37 kidney kidney NN cord-281487-x0a9qgjs 217 38 transplantation transplantation NN cord-281487-x0a9qgjs 217 39 during during IN cord-281487-x0a9qgjs 217 40 the the DT cord-281487-x0a9qgjs 217 41 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 217 42 pandemic pandemic NN cord-281487-x0a9qgjs 217 43 : : : cord-281487-x0a9qgjs 217 44 a a DT cord-281487-x0a9qgjs 217 45 stochastic stochastic JJ cord-281487-x0a9qgjs 217 46 simulation simulation NN cord-281487-x0a9qgjs 217 47 and and CC cord-281487-x0a9qgjs 217 48 machine machine NN cord-281487-x0a9qgjs 217 49 learning learning NN cord-281487-x0a9qgjs 217 50 study study NN cord-281487-x0a9qgjs 217 51 Angiotensin Angiotensin NNP cord-281487-x0a9qgjs 217 52 - - HYPH cord-281487-x0a9qgjs 217 53 converting convert VBG cord-281487-x0a9qgjs 217 54 enzyme enzyme NN cord-281487-x0a9qgjs 217 55 2 2 CD cord-281487-x0a9qgjs 217 56 and and CC cord-281487-x0a9qgjs 217 57 antihypertensives antihypertensives NNP cord-281487-x0a9qgjs 217 58 ( ( -LRB- cord-281487-x0a9qgjs 217 59 angiotensin angiotensin NN cord-281487-x0a9qgjs 217 60 receptor receptor NN cord-281487-x0a9qgjs 217 61 blockers blocker NNS cord-281487-x0a9qgjs 217 62 and and CC cord-281487-x0a9qgjs 217 63 angiotensin angiotensin NN cord-281487-x0a9qgjs 217 64 - - HYPH cord-281487-x0a9qgjs 217 65 converting convert VBG cord-281487-x0a9qgjs 217 66 enzyme enzyme NN cord-281487-x0a9qgjs 217 67 inhibitors inhibitor NNS cord-281487-x0a9qgjs 217 68 ) ) -RRB- cord-281487-x0a9qgjs 217 69 in in IN cord-281487-x0a9qgjs 217 70 coronavirus coronavirus NN cord-281487-x0a9qgjs 217 71 disease disease NN cord-281487-x0a9qgjs 218 1 2019 2019 CD cord-281487-x0a9qgjs 218 2 Controversies controversy NNS cord-281487-x0a9qgjs 218 3 of of IN cord-281487-x0a9qgjs 218 4 renin renin NN cord-281487-x0a9qgjs 218 5 - - HYPH cord-281487-x0a9qgjs 218 6 angiotensin angiotensin NN cord-281487-x0a9qgjs 218 7 system system NN cord-281487-x0a9qgjs 218 8 inhibition inhibition NN cord-281487-x0a9qgjs 218 9 during during IN cord-281487-x0a9qgjs 218 10 the the DT cord-281487-x0a9qgjs 218 11 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 218 12 pandemic pandemic NN cord-281487-x0a9qgjs 218 13 Acute acute JJ cord-281487-x0a9qgjs 218 14 kidney kidney NN cord-281487-x0a9qgjs 218 15 injury injury NN cord-281487-x0a9qgjs 218 16 in in IN cord-281487-x0a9qgjs 218 17 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 218 18 : : : cord-281487-x0a9qgjs 218 19 emerging emerge VBG cord-281487-x0a9qgjs 218 20 evidence evidence NN cord-281487-x0a9qgjs 218 21 of of IN cord-281487-x0a9qgjs 218 22 a a DT cord-281487-x0a9qgjs 218 23 distinct distinct JJ cord-281487-x0a9qgjs 218 24 pathophysiology pathophysiology NN cord-281487-x0a9qgjs 218 25 Features feature NNS cord-281487-x0a9qgjs 218 26 of of IN cord-281487-x0a9qgjs 218 27 20 20 CD cord-281487-x0a9qgjs 218 28 133 133 CD cord-281487-x0a9qgjs 218 29 UK UK NNP cord-281487-x0a9qgjs 218 30 patients patient NNS cord-281487-x0a9qgjs 218 31 in in IN cord-281487-x0a9qgjs 218 32 hospital hospital NN cord-281487-x0a9qgjs 218 33 with with IN cord-281487-x0a9qgjs 218 34 covid-19 covid-19 NNP cord-281487-x0a9qgjs 218 35 using use VBG cord-281487-x0a9qgjs 218 36 the the DT cord-281487-x0a9qgjs 218 37 ISARIC ISARIC NNP cord-281487-x0a9qgjs 218 38 WHO WHO NNP cord-281487-x0a9qgjs 218 39 Clinical Clinical NNP cord-281487-x0a9qgjs 218 40 Characterisation Characterisation NNP cord-281487-x0a9qgjs 218 41 Protocol Protocol NNP cord-281487-x0a9qgjs 218 42 : : : cord-281487-x0a9qgjs 218 43 prospective prospective JJ cord-281487-x0a9qgjs 218 44 observational observational JJ cord-281487-x0a9qgjs 218 45 cohort cohort NN cord-281487-x0a9qgjs 218 46 study study NN cord-281487-x0a9qgjs 218 47 Infection Infection NNP cord-281487-x0a9qgjs 218 48 in in IN cord-281487-x0a9qgjs 218 49 organ organ NN cord-281487-x0a9qgjs 218 50 transplantation transplantation NN cord-281487-x0a9qgjs 218 51 Clinical clinical JJ cord-281487-x0a9qgjs 218 52 characteristics characteristic NNS cord-281487-x0a9qgjs 218 53 and and CC cord-281487-x0a9qgjs 218 54 outcomes outcome NNS cord-281487-x0a9qgjs 218 55 of of IN cord-281487-x0a9qgjs 218 56 COVID-19 covid-19 CD cord-281487-x0a9qgjs 218 57 in in IN cord-281487-x0a9qgjs 218 58 solid solid JJ cord-281487-x0a9qgjs 218 59 organ organ NN cord-281487-x0a9qgjs 218 60 transplant transplant NN cord-281487-x0a9qgjs 218 61 recipients recipient NNS cord-281487-x0a9qgjs 218 62 : : : cord-281487-x0a9qgjs 218 63 a a DT cord-281487-x0a9qgjs 218 64 case case NN cord-281487-x0a9qgjs 218 65 - - HYPH cord-281487-x0a9qgjs 218 66 control control NN cord-281487-x0a9qgjs 218 67 study study NN cord-281487-x0a9qgjs 218 68 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 218 69 in in IN cord-281487-x0a9qgjs 218 70 solid solid JJ cord-281487-x0a9qgjs 218 71 organ organ NN cord-281487-x0a9qgjs 218 72 transplant transplant NN cord-281487-x0a9qgjs 218 73 recipients recipient NNS cord-281487-x0a9qgjs 218 74 : : : cord-281487-x0a9qgjs 218 75 dynamics dynamic NNS cord-281487-x0a9qgjs 218 76 of of IN cord-281487-x0a9qgjs 218 77 disease disease NN cord-281487-x0a9qgjs 218 78 progression progression NN cord-281487-x0a9qgjs 218 79 and and CC cord-281487-x0a9qgjs 218 80 inflammatory inflammatory JJ cord-281487-x0a9qgjs 218 81 markers marker NNS cord-281487-x0a9qgjs 218 82 in in IN cord-281487-x0a9qgjs 218 83 ICU ICU NNP cord-281487-x0a9qgjs 218 84 and and CC cord-281487-x0a9qgjs 218 85 non non JJ cord-281487-x0a9qgjs 218 86 - - JJ cord-281487-x0a9qgjs 218 87 ICU ICU NNP cord-281487-x0a9qgjs 218 88 admitted admit VBD cord-281487-x0a9qgjs 218 89 patients patient NNS cord-281487-x0a9qgjs 218 90 COVID-19 covid-19 VBP cord-281487-x0a9qgjs 218 91 in in IN cord-281487-x0a9qgjs 218 92 solid solid JJ cord-281487-x0a9qgjs 218 93 organ organ NN cord-281487-x0a9qgjs 218 94 transplant transplant NN cord-281487-x0a9qgjs 218 95 : : : cord-281487-x0a9qgjs 219 1 a a DT cord-281487-x0a9qgjs 219 2 multicenter multicenter JJ cord-281487-x0a9qgjs 219 3 cohort cohort NN cord-281487-x0a9qgjs 219 4 study study NN cord-281487-x0a9qgjs 219 5 Clinical clinical JJ cord-281487-x0a9qgjs 219 6 characteristics characteristic NNS cord-281487-x0a9qgjs 219 7 of of IN cord-281487-x0a9qgjs 219 8 coronavirus coronavirus NN cord-281487-x0a9qgjs 219 9 disease disease NN cord-281487-x0a9qgjs 219 10 2019 2019 CD cord-281487-x0a9qgjs 219 11 in in IN cord-281487-x0a9qgjs 219 12 China China NNP cord-281487-x0a9qgjs 219 13 RNA RNA NNP cord-281487-x0a9qgjs 219 14 respiratory respiratory JJ cord-281487-x0a9qgjs 219 15 viral viral JJ cord-281487-x0a9qgjs 219 16 infections infection NNS cord-281487-x0a9qgjs 219 17 in in IN cord-281487-x0a9qgjs 219 18 solid solid JJ cord-281487-x0a9qgjs 219 19 organ organ NN cord-281487-x0a9qgjs 219 20 transplant transplant NN cord-281487-x0a9qgjs 219 21 recipients recipient NNS cord-281487-x0a9qgjs 219 22 : : : cord-281487-x0a9qgjs 220 1 guidelines guideline NNS cord-281487-x0a9qgjs 220 2 from from IN cord-281487-x0a9qgjs 220 3 the the DT cord-281487-x0a9qgjs 220 4 American American NNP cord-281487-x0a9qgjs 220 5 Society Society NNP cord-281487-x0a9qgjs 220 6 of of IN cord-281487-x0a9qgjs 220 7 Transplantation Transplantation NNP cord-281487-x0a9qgjs 220 8 Infectious Infectious NNP cord-281487-x0a9qgjs 220 9 Diseases Diseases NNPS cord-281487-x0a9qgjs 220 10 Community Community NNP cord-281487-x0a9qgjs 220 11 of of IN cord-281487-x0a9qgjs 220 12 Practice Practice NNP cord-281487-x0a9qgjs 220 13 Impact Impact NNP cord-281487-x0a9qgjs 220 14 of of IN cord-281487-x0a9qgjs 220 15 solid solid JJ cord-281487-x0a9qgjs 220 16 organ organ NN cord-281487-x0a9qgjs 220 17 transplantation transplantation NN cord-281487-x0a9qgjs 220 18 and and CC cord-281487-x0a9qgjs 220 19 immunosuppression immunosuppression NN cord-281487-x0a9qgjs 220 20 on on IN cord-281487-x0a9qgjs 220 21 fever fever NN cord-281487-x0a9qgjs 220 22 , , , cord-281487-x0a9qgjs 220 23 leukocytosis leukocytosis NN cord-281487-x0a9qgjs 220 24 , , , cord-281487-x0a9qgjs 220 25 and and CC cord-281487-x0a9qgjs 220 26 physiologic physiologic JJ cord-281487-x0a9qgjs 220 27 response response NN cord-281487-x0a9qgjs 220 28 during during IN cord-281487-x0a9qgjs 220 29 bacterial bacterial JJ cord-281487-x0a9qgjs 220 30 and and CC cord-281487-x0a9qgjs 220 31 fungal fungal JJ cord-281487-x0a9qgjs 220 32 infections infection NNS cord-281487-x0a9qgjs 220 33 Covid-19 covid-19 VBP cord-281487-x0a9qgjs 220 34 and and CC cord-281487-x0a9qgjs 220 35 kidney kidney NN cord-281487-x0a9qgjs 220 36 transplantation transplantation NN cord-281487-x0a9qgjs 220 37 COVID-19 covid-19 VBP cord-281487-x0a9qgjs 220 38 in in IN cord-281487-x0a9qgjs 220 39 solid solid JJ cord-281487-x0a9qgjs 220 40 organ organ NN cord-281487-x0a9qgjs 220 41 transplant transplant NN cord-281487-x0a9qgjs 220 42 recipients recipient NNS cord-281487-x0a9qgjs 220 43 : : : cord-281487-x0a9qgjs 220 44 initial initial JJ cord-281487-x0a9qgjs 220 45 report report NN cord-281487-x0a9qgjs 220 46 from from IN cord-281487-x0a9qgjs 220 47 the the DT cord-281487-x0a9qgjs 220 48 US US NNP cord-281487-x0a9qgjs 220 49 epicenter epicenter NN cord-281487-x0a9qgjs 220 50 Early early JJ cord-281487-x0a9qgjs 220 51 experience experience NN cord-281487-x0a9qgjs 220 52 with with IN cord-281487-x0a9qgjs 220 53 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 220 54 and and CC cord-281487-x0a9qgjs 220 55 solid solid JJ cord-281487-x0a9qgjs 220 56 organ organ NN cord-281487-x0a9qgjs 220 57 transplantation transplantation NN cord-281487-x0a9qgjs 220 58 at at IN cord-281487-x0a9qgjs 220 59 a a DT cord-281487-x0a9qgjs 220 60 US US NNP cord-281487-x0a9qgjs 220 61 high high JJ cord-281487-x0a9qgjs 220 62 - - HYPH cord-281487-x0a9qgjs 220 63 volume volume NN cord-281487-x0a9qgjs 220 64 transplant transplant NN cord-281487-x0a9qgjs 220 65 center center NN cord-281487-x0a9qgjs 220 66 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 220 67 in in IN cord-281487-x0a9qgjs 220 68 solid solid JJ cord-281487-x0a9qgjs 220 69 organ organ NN cord-281487-x0a9qgjs 220 70 transplant transplant NN cord-281487-x0a9qgjs 220 71 recipients recipient NNS cord-281487-x0a9qgjs 220 72 : : : cord-281487-x0a9qgjs 220 73 a a DT cord-281487-x0a9qgjs 220 74 single single JJ cord-281487-x0a9qgjs 220 75 - - HYPH cord-281487-x0a9qgjs 220 76 center center NN cord-281487-x0a9qgjs 220 77 case case NN cord-281487-x0a9qgjs 220 78 series series NN cord-281487-x0a9qgjs 220 79 from from IN cord-281487-x0a9qgjs 220 80 Spain Spain NNP cord-281487-x0a9qgjs 220 81 Early early JJ cord-281487-x0a9qgjs 220 82 description description NN cord-281487-x0a9qgjs 220 83 of of IN cord-281487-x0a9qgjs 220 84 coronavirus coronavirus NN cord-281487-x0a9qgjs 220 85 2019 2019 CD cord-281487-x0a9qgjs 220 86 disease disease NN cord-281487-x0a9qgjs 220 87 in in IN cord-281487-x0a9qgjs 220 88 kidney kidney NN cord-281487-x0a9qgjs 220 89 transplant transplant NN cord-281487-x0a9qgjs 220 90 recipients recipient NNS cord-281487-x0a9qgjs 220 91 in in IN cord-281487-x0a9qgjs 220 92 New New NNP cord-281487-x0a9qgjs 220 93 York York NNP cord-281487-x0a9qgjs 220 94 First first JJ cord-281487-x0a9qgjs 220 95 experience experience NN cord-281487-x0a9qgjs 220 96 of of IN cord-281487-x0a9qgjs 220 97 SARS SARS NNP cord-281487-x0a9qgjs 220 98 - - HYPH cord-281487-x0a9qgjs 220 99 CoV-2 CoV-2 NNP cord-281487-x0a9qgjs 220 100 infections infection NNS cord-281487-x0a9qgjs 220 101 in in IN cord-281487-x0a9qgjs 220 102 solid solid JJ cord-281487-x0a9qgjs 220 103 organ organ NN cord-281487-x0a9qgjs 220 104 transplant transplant NN cord-281487-x0a9qgjs 220 105 recipients recipient NNS cord-281487-x0a9qgjs 220 106 in in IN cord-281487-x0a9qgjs 220 107 the the DT cord-281487-x0a9qgjs 220 108 Swiss swiss JJ cord-281487-x0a9qgjs 220 109 transplant transplant NN cord-281487-x0a9qgjs 220 110 cohort cohort NN cord-281487-x0a9qgjs 220 111 study study NN cord-281487-x0a9qgjs 220 112 A a DT cord-281487-x0a9qgjs 220 113 single single JJ cord-281487-x0a9qgjs 220 114 center center NN cord-281487-x0a9qgjs 220 115 observational observational JJ cord-281487-x0a9qgjs 220 116 study study NN cord-281487-x0a9qgjs 220 117 of of IN cord-281487-x0a9qgjs 220 118 the the DT cord-281487-x0a9qgjs 220 119 clinical clinical JJ cord-281487-x0a9qgjs 220 120 characteristics characteristic NNS cord-281487-x0a9qgjs 220 121 and and CC cord-281487-x0a9qgjs 220 122 short short JJ cord-281487-x0a9qgjs 220 123 - - HYPH cord-281487-x0a9qgjs 220 124 term term NN cord-281487-x0a9qgjs 220 125 outcome outcome NN cord-281487-x0a9qgjs 220 126 of of IN cord-281487-x0a9qgjs 220 127 20 20 CD cord-281487-x0a9qgjs 220 128 kidney kidney NN cord-281487-x0a9qgjs 220 129 transplant transplant NN cord-281487-x0a9qgjs 220 130 patients patient NNS cord-281487-x0a9qgjs 220 131 admitted admit VBN cord-281487-x0a9qgjs 220 132 for for IN cord-281487-x0a9qgjs 220 133 SARS SARS NNP cord-281487-x0a9qgjs 220 134 - - HYPH cord-281487-x0a9qgjs 220 135 CoV2 CoV2 NNP cord-281487-x0a9qgjs 220 136 pneumonia pneumonia NN cord-281487-x0a9qgjs 220 137 Clinical clinical JJ cord-281487-x0a9qgjs 220 138 features feature NNS cord-281487-x0a9qgjs 220 139 of of IN cord-281487-x0a9qgjs 220 140 69 69 CD cord-281487-x0a9qgjs 220 141 cases case NNS cord-281487-x0a9qgjs 220 142 with with IN cord-281487-x0a9qgjs 220 143 coronavirus coronavirus NN cord-281487-x0a9qgjs 220 144 disease disease NN cord-281487-x0a9qgjs 220 145 Radiological radiological JJ cord-281487-x0a9qgjs 220 146 findings finding NNS cord-281487-x0a9qgjs 220 147 from from IN cord-281487-x0a9qgjs 220 148 81 81 CD cord-281487-x0a9qgjs 220 149 patients patient NNS cord-281487-x0a9qgjs 220 150 with with IN cord-281487-x0a9qgjs 220 151 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 220 152 pneumonia pneumonia NN cord-281487-x0a9qgjs 220 153 in in IN cord-281487-x0a9qgjs 220 154 Wuhan Wuhan NNP cord-281487-x0a9qgjs 220 155 , , , cord-281487-x0a9qgjs 220 156 China China NNP cord-281487-x0a9qgjs 220 157 : : : cord-281487-x0a9qgjs 220 158 a a DT cord-281487-x0a9qgjs 220 159 descriptive descriptive JJ cord-281487-x0a9qgjs 220 160 study study NN cord-281487-x0a9qgjs 220 161 Clinical clinical JJ cord-281487-x0a9qgjs 220 162 and and CC cord-281487-x0a9qgjs 220 163 immunological immunological JJ cord-281487-x0a9qgjs 220 164 features feature NNS cord-281487-x0a9qgjs 220 165 of of IN cord-281487-x0a9qgjs 220 166 severe severe JJ cord-281487-x0a9qgjs 220 167 and and CC cord-281487-x0a9qgjs 220 168 moderate moderate JJ cord-281487-x0a9qgjs 220 169 coronavirus coronavirus NN cord-281487-x0a9qgjs 220 170 disease disease NN cord-281487-x0a9qgjs 220 171 2019 2019 CD cord-281487-x0a9qgjs 220 172 Prediction Prediction NNP cord-281487-x0a9qgjs 220 173 for for IN cord-281487-x0a9qgjs 220 174 progression progression NN cord-281487-x0a9qgjs 220 175 risk risk NN cord-281487-x0a9qgjs 220 176 in in IN cord-281487-x0a9qgjs 220 177 patients patient NNS cord-281487-x0a9qgjs 220 178 with with IN cord-281487-x0a9qgjs 220 179 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 220 180 pneumonia pneumonia NN cord-281487-x0a9qgjs 220 181 : : : cord-281487-x0a9qgjs 220 182 the the DT cord-281487-x0a9qgjs 220 183 CALL call NN cord-281487-x0a9qgjs 220 184 score score NN cord-281487-x0a9qgjs 220 185 Prognostic prognostic JJ cord-281487-x0a9qgjs 220 186 value value NN cord-281487-x0a9qgjs 220 187 of of IN cord-281487-x0a9qgjs 220 188 interleukin-6 interleukin-6 NNP cord-281487-x0a9qgjs 220 189 , , , cord-281487-x0a9qgjs 220 190 C C NNP cord-281487-x0a9qgjs 220 191 - - HYPH cord-281487-x0a9qgjs 220 192 reactive reactive JJ cord-281487-x0a9qgjs 220 193 protein protein NN cord-281487-x0a9qgjs 220 194 , , , cord-281487-x0a9qgjs 220 195 and and CC cord-281487-x0a9qgjs 220 196 procalcitonin procalcitonin NNS cord-281487-x0a9qgjs 220 197 in in IN cord-281487-x0a9qgjs 220 198 patients patient NNS cord-281487-x0a9qgjs 220 199 with with IN cord-281487-x0a9qgjs 220 200 COVID-19 covid-19 DT cord-281487-x0a9qgjs 220 201 ISTH ISTH NNP cord-281487-x0a9qgjs 220 202 interim interim JJ cord-281487-x0a9qgjs 220 203 guidance guidance NN cord-281487-x0a9qgjs 220 204 on on IN cord-281487-x0a9qgjs 220 205 recognition recognition NN cord-281487-x0a9qgjs 220 206 and and CC cord-281487-x0a9qgjs 220 207 management management NN cord-281487-x0a9qgjs 220 208 of of IN cord-281487-x0a9qgjs 220 209 coagulopathy coagulopathy NN cord-281487-x0a9qgjs 220 210 in in IN cord-281487-x0a9qgjs 220 211 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 220 212 Clinical Clinical NNP cord-281487-x0a9qgjs 220 213 course course NN cord-281487-x0a9qgjs 220 214 and and CC cord-281487-x0a9qgjs 220 215 risk risk NN cord-281487-x0a9qgjs 220 216 factors factor NNS cord-281487-x0a9qgjs 220 217 for for IN cord-281487-x0a9qgjs 220 218 mortality mortality NN cord-281487-x0a9qgjs 220 219 of of IN cord-281487-x0a9qgjs 220 220 adult adult NN cord-281487-x0a9qgjs 220 221 inpatients inpatient NNS cord-281487-x0a9qgjs 220 222 with with IN cord-281487-x0a9qgjs 220 223 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 220 224 in in IN cord-281487-x0a9qgjs 220 225 Wuhan Wuhan NNP cord-281487-x0a9qgjs 220 226 , , , cord-281487-x0a9qgjs 220 227 China China NNP cord-281487-x0a9qgjs 220 228 : : : cord-281487-x0a9qgjs 221 1 a a DT cord-281487-x0a9qgjs 221 2 retrospective retrospective JJ cord-281487-x0a9qgjs 221 3 cohort cohort NN cord-281487-x0a9qgjs 221 4 study study NN cord-281487-x0a9qgjs 221 5 Co co NN cord-281487-x0a9qgjs 221 6 - - NN cord-281487-x0a9qgjs 221 7 infection infection NN cord-281487-x0a9qgjs 221 8 with with IN cord-281487-x0a9qgjs 221 9 respiratory respiratory JJ cord-281487-x0a9qgjs 221 10 pathogens pathogen NNS cord-281487-x0a9qgjs 221 11 among among IN cord-281487-x0a9qgjs 221 12 COVID-2019 COVID-2019 NNP cord-281487-x0a9qgjs 221 13 cases case NNS cord-281487-x0a9qgjs 221 14 guidance guidance NN cord-281487-x0a9qgjs 221 15 for for IN cord-281487-x0a9qgjs 221 16 the the DT cord-281487-x0a9qgjs 221 17 diagnosis diagnosis NN cord-281487-x0a9qgjs 221 18 and and CC cord-281487-x0a9qgjs 221 19 management management NN cord-281487-x0a9qgjs 221 20 of of IN cord-281487-x0a9qgjs 221 21 CV CV NNP cord-281487-x0a9qgjs 221 22 disease disease NN cord-281487-x0a9qgjs 221 23 during during IN cord-281487-x0a9qgjs 221 24 the the DT cord-281487-x0a9qgjs 221 25 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 221 26 pandemic pandemic NN cord-281487-x0a9qgjs 221 27 A a DT cord-281487-x0a9qgjs 221 28 clinical clinical JJ cord-281487-x0a9qgjs 221 29 risk risk NN cord-281487-x0a9qgjs 221 30 score score NN cord-281487-x0a9qgjs 221 31 to to TO cord-281487-x0a9qgjs 221 32 identify identify VB cord-281487-x0a9qgjs 221 33 patients patient NNS cord-281487-x0a9qgjs 221 34 with with IN cord-281487-x0a9qgjs 221 35 COVID-19 covid-19 CD cord-281487-x0a9qgjs 221 36 at at IN cord-281487-x0a9qgjs 221 37 high high JJ cord-281487-x0a9qgjs 221 38 risk risk NN cord-281487-x0a9qgjs 221 39 of of IN cord-281487-x0a9qgjs 221 40 critical critical JJ cord-281487-x0a9qgjs 221 41 care care NN cord-281487-x0a9qgjs 221 42 admission admission NN cord-281487-x0a9qgjs 221 43 or or CC cord-281487-x0a9qgjs 221 44 death death NN cord-281487-x0a9qgjs 221 45 : : : cord-281487-x0a9qgjs 222 1 An an DT cord-281487-x0a9qgjs 222 2 observational observational JJ cord-281487-x0a9qgjs 222 3 cohort cohort NN cord-281487-x0a9qgjs 222 4 study study NN cord-281487-x0a9qgjs 222 5 Clinical clinical JJ cord-281487-x0a9qgjs 222 6 best good JJS cord-281487-x0a9qgjs 222 7 practice practice NN cord-281487-x0a9qgjs 222 8 advice advice NN cord-281487-x0a9qgjs 222 9 for for IN cord-281487-x0a9qgjs 222 10 hepatology hepatology NN cord-281487-x0a9qgjs 222 11 and and CC cord-281487-x0a9qgjs 222 12 liver liver NN cord-281487-x0a9qgjs 222 13 transplant transplant NN cord-281487-x0a9qgjs 222 14 providers provider NNS cord-281487-x0a9qgjs 222 15 during during IN cord-281487-x0a9qgjs 222 16 the the DT cord-281487-x0a9qgjs 222 17 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 222 18 pandemic pandemic NN cord-281487-x0a9qgjs 222 19 : : : cord-281487-x0a9qgjs 223 1 AASLD AASLD NNP cord-281487-x0a9qgjs 223 2 Expert Expert NNP cord-281487-x0a9qgjs 223 3 Panel Panel NNP cord-281487-x0a9qgjs 223 4 Consensus Consensus NNP cord-281487-x0a9qgjs 223 5 Statement Statement NNP cord-281487-x0a9qgjs 224 1 COVID-19 covid-19 VB cord-281487-x0a9qgjs 224 2 : : : cord-281487-x0a9qgjs 224 3 abnormal abnormal JJ cord-281487-x0a9qgjs 224 4 liver liver NN cord-281487-x0a9qgjs 224 5 function function NN cord-281487-x0a9qgjs 224 6 tests test VBZ cord-281487-x0a9qgjs 224 7 Kidney kidney NN cord-281487-x0a9qgjs 224 8 disease disease NN cord-281487-x0a9qgjs 224 9 is be VBZ cord-281487-x0a9qgjs 224 10 associated associate VBN cord-281487-x0a9qgjs 224 11 with with IN cord-281487-x0a9qgjs 224 12 in in IN cord-281487-x0a9qgjs 224 13 - - HYPH cord-281487-x0a9qgjs 224 14 hospital hospital NN cord-281487-x0a9qgjs 224 15 death death NN cord-281487-x0a9qgjs 224 16 of of IN cord-281487-x0a9qgjs 224 17 patients patient NNS cord-281487-x0a9qgjs 224 18 with with IN cord-281487-x0a9qgjs 224 19 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 224 20 Management Management NNP cord-281487-x0a9qgjs 224 21 of of IN cord-281487-x0a9qgjs 224 22 acute acute JJ cord-281487-x0a9qgjs 224 23 kidney kidney NN cord-281487-x0a9qgjs 224 24 injury injury NN cord-281487-x0a9qgjs 224 25 in in IN cord-281487-x0a9qgjs 224 26 patients patient NNS cord-281487-x0a9qgjs 224 27 with with IN cord-281487-x0a9qgjs 224 28 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 224 29 Is be VBZ cord-281487-x0a9qgjs 224 30 the the DT cord-281487-x0a9qgjs 224 31 kidney kidney NN cord-281487-x0a9qgjs 224 32 a a DT cord-281487-x0a9qgjs 224 33 target target NN cord-281487-x0a9qgjs 224 34 of of IN cord-281487-x0a9qgjs 224 35 SARS SARS NNP cord-281487-x0a9qgjs 224 36 - - HYPH cord-281487-x0a9qgjs 224 37 CoV-2 CoV-2 NNP cord-281487-x0a9qgjs 224 38 ? ? . cord-281487-x0a9qgjs 225 1 Incidence incidence NN cord-281487-x0a9qgjs 225 2 of of IN cord-281487-x0a9qgjs 225 3 thrombotic thrombotic JJ cord-281487-x0a9qgjs 225 4 complications complication NNS cord-281487-x0a9qgjs 225 5 in in IN cord-281487-x0a9qgjs 225 6 critically critically RB cord-281487-x0a9qgjs 225 7 ill ill JJ cord-281487-x0a9qgjs 225 8 ICU ICU NNP cord-281487-x0a9qgjs 225 9 patients patient NNS cord-281487-x0a9qgjs 225 10 with with IN cord-281487-x0a9qgjs 225 11 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 225 12 Coagulation Coagulation NNP cord-281487-x0a9qgjs 225 13 abnormalities abnormality NNS cord-281487-x0a9qgjs 225 14 and and CC cord-281487-x0a9qgjs 225 15 thrombosis thrombosis NN cord-281487-x0a9qgjs 225 16 in in IN cord-281487-x0a9qgjs 225 17 patients patient NNS cord-281487-x0a9qgjs 225 18 with with IN cord-281487-x0a9qgjs 225 19 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 225 20 Renal Renal NNP cord-281487-x0a9qgjs 225 21 histopathological histopathological NNP cord-281487-x0a9qgjs 225 22 analysis analysis NN cord-281487-x0a9qgjs 225 23 of of IN cord-281487-x0a9qgjs 225 24 26 26 CD cord-281487-x0a9qgjs 225 25 postmortem postmortem JJ cord-281487-x0a9qgjs 225 26 findings finding NNS cord-281487-x0a9qgjs 225 27 of of IN cord-281487-x0a9qgjs 225 28 patients patient NNS cord-281487-x0a9qgjs 225 29 with with IN cord-281487-x0a9qgjs 225 30 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 225 31 in in IN cord-281487-x0a9qgjs 225 32 China China NNP cord-281487-x0a9qgjs 225 33 Co Co NNS cord-281487-x0a9qgjs 225 34 - - NNS cord-281487-x0a9qgjs 225 35 infections infection NNS cord-281487-x0a9qgjs 225 36 among among IN cord-281487-x0a9qgjs 225 37 patients patient NNS cord-281487-x0a9qgjs 225 38 with with IN cord-281487-x0a9qgjs 225 39 COVID-19 covid-19 CD cord-281487-x0a9qgjs 225 40 : : : cord-281487-x0a9qgjs 225 41 the the DT cord-281487-x0a9qgjs 225 42 need need NN cord-281487-x0a9qgjs 225 43 for for IN cord-281487-x0a9qgjs 225 44 combination combination NN cord-281487-x0a9qgjs 225 45 therapy therapy NN cord-281487-x0a9qgjs 225 46 with with IN cord-281487-x0a9qgjs 225 47 non non JJ cord-281487-x0a9qgjs 225 48 - - JJ cord-281487-x0a9qgjs 225 49 anti anti JJ cord-281487-x0a9qgjs 225 50 - - JJ cord-281487-x0a9qgjs 225 51 SARS SARS NNP cord-281487-x0a9qgjs 225 52 - - HYPH cord-281487-x0a9qgjs 225 53 CoV-2 CoV-2 NNP cord-281487-x0a9qgjs 225 54 agents agent NNS cord-281487-x0a9qgjs 225 55 ? ? . cord-281487-x0a9qgjs 226 1 Diagnostic diagnostic JJ cord-281487-x0a9qgjs 226 2 and and CC cord-281487-x0a9qgjs 226 3 therapeutic therapeutic JJ cord-281487-x0a9qgjs 226 4 approach approach NN cord-281487-x0a9qgjs 226 5 to to IN cord-281487-x0a9qgjs 226 6 infectious infectious JJ cord-281487-x0a9qgjs 226 7 diseases disease NNS cord-281487-x0a9qgjs 226 8 in in IN cord-281487-x0a9qgjs 226 9 solid solid JJ cord-281487-x0a9qgjs 226 10 organ organ NN cord-281487-x0a9qgjs 226 11 transplant transplant NN cord-281487-x0a9qgjs 226 12 recipients recipient NNS cord-281487-x0a9qgjs 226 13 Procalcitonin Procalcitonin NNP cord-281487-x0a9qgjs 226 14 in in IN cord-281487-x0a9qgjs 226 15 patients patient NNS cord-281487-x0a9qgjs 226 16 with with IN cord-281487-x0a9qgjs 226 17 severe severe JJ cord-281487-x0a9qgjs 226 18 coronavirus coronavirus NN cord-281487-x0a9qgjs 226 19 disease disease NN cord-281487-x0a9qgjs 226 20 2019 2019 CD cord-281487-x0a9qgjs 226 21 ( ( -LRB- cord-281487-x0a9qgjs 226 22 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 226 23 ) ) -RRB- cord-281487-x0a9qgjs 226 24 : : : cord-281487-x0a9qgjs 226 25 a a DT cord-281487-x0a9qgjs 226 26 meta meta JJ cord-281487-x0a9qgjs 226 27 - - HYPH cord-281487-x0a9qgjs 226 28 analysis analysis NN cord-281487-x0a9qgjs 226 29 Disposable disposable JJ cord-281487-x0a9qgjs 226 30 isolation isolation NN cord-281487-x0a9qgjs 226 31 device device NN cord-281487-x0a9qgjs 226 32 to to TO cord-281487-x0a9qgjs 226 33 reduce reduce VB cord-281487-x0a9qgjs 226 34 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 226 35 contamination contamination NN cord-281487-x0a9qgjs 226 36 during during IN cord-281487-x0a9qgjs 226 37 CT CT NNP cord-281487-x0a9qgjs 226 38 scanning scanning NN cord-281487-x0a9qgjs 226 39 Findings Findings NNP cord-281487-x0a9qgjs 226 40 of of IN cord-281487-x0a9qgjs 226 41 lung lung NN cord-281487-x0a9qgjs 226 42 ultrasonography ultrasonography NN cord-281487-x0a9qgjs 226 43 of of IN cord-281487-x0a9qgjs 226 44 novel novel NNP cord-281487-x0a9qgjs 226 45 corona corona NNP cord-281487-x0a9qgjs 226 46 virus virus NN cord-281487-x0a9qgjs 226 47 pneumonia pneumonia NN cord-281487-x0a9qgjs 226 48 during during IN cord-281487-x0a9qgjs 226 49 the the DT cord-281487-x0a9qgjs 226 50 2019 2019 CD cord-281487-x0a9qgjs 226 51 - - SYM cord-281487-x0a9qgjs 226 52 2020 2020 CD cord-281487-x0a9qgjs 226 53 epidemic epidemic NN cord-281487-x0a9qgjs 226 54 Thoracic thoracic JJ cord-281487-x0a9qgjs 226 55 ultrasonography ultrasonography NN cord-281487-x0a9qgjs 226 56 : : : cord-281487-x0a9qgjs 226 57 a a DT cord-281487-x0a9qgjs 226 58 narrative narrative NN cord-281487-x0a9qgjs 226 59 review review NN cord-281487-x0a9qgjs 226 60 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 226 61 diagnosis diagnosis NN cord-281487-x0a9qgjs 226 62 and and CC cord-281487-x0a9qgjs 226 63 management management NN cord-281487-x0a9qgjs 226 64 : : : cord-281487-x0a9qgjs 226 65 a a DT cord-281487-x0a9qgjs 226 66 comprehensive comprehensive JJ cord-281487-x0a9qgjs 226 67 review review NN cord-281487-x0a9qgjs 227 1 The the DT cord-281487-x0a9qgjs 227 2 incubation incubation NN cord-281487-x0a9qgjs 227 3 period period NN cord-281487-x0a9qgjs 227 4 of of IN cord-281487-x0a9qgjs 227 5 coronavirus coronavirus NN cord-281487-x0a9qgjs 227 6 disease disease NN cord-281487-x0a9qgjs 227 7 2019 2019 CD cord-281487-x0a9qgjs 227 8 ( ( -LRB- cord-281487-x0a9qgjs 227 9 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 227 10 ) ) -RRB- cord-281487-x0a9qgjs 227 11 from from IN cord-281487-x0a9qgjs 227 12 publicly publicly RB cord-281487-x0a9qgjs 227 13 reported report VBN cord-281487-x0a9qgjs 227 14 confirmed confirm VBN cord-281487-x0a9qgjs 227 15 cases case NNS cord-281487-x0a9qgjs 227 16 : : : cord-281487-x0a9qgjs 227 17 estimation estimation NN cord-281487-x0a9qgjs 227 18 and and CC cord-281487-x0a9qgjs 227 19 application application VB cord-281487-x0a9qgjs 227 20 Temporal temporal JJ cord-281487-x0a9qgjs 227 21 dynamics dynamic NNS cord-281487-x0a9qgjs 227 22 in in IN cord-281487-x0a9qgjs 227 23 viral viral JJ cord-281487-x0a9qgjs 227 24 shedding shedding NN cord-281487-x0a9qgjs 227 25 and and CC cord-281487-x0a9qgjs 227 26 transmissibility transmissibility NN cord-281487-x0a9qgjs 227 27 of of IN cord-281487-x0a9qgjs 227 28 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 227 29 Diagnosis Diagnosis NNP cord-281487-x0a9qgjs 227 30 and and CC cord-281487-x0a9qgjs 227 31 treatment treatment NN cord-281487-x0a9qgjs 227 32 of of IN cord-281487-x0a9qgjs 227 33 coronavirus coronavirus NN cord-281487-x0a9qgjs 227 34 disease disease NN cord-281487-x0a9qgjs 227 35 2019 2019 CD cord-281487-x0a9qgjs 227 36 ( ( -LRB- cord-281487-x0a9qgjs 227 37 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 227 38 ) ) -RRB- cord-281487-x0a9qgjs 227 39 : : : cord-281487-x0a9qgjs 227 40 laboratory laboratory NN cord-281487-x0a9qgjs 227 41 , , , cord-281487-x0a9qgjs 227 42 PCR PCR NNP cord-281487-x0a9qgjs 227 43 , , , cord-281487-x0a9qgjs 227 44 and and CC cord-281487-x0a9qgjs 227 45 chest chest NN cord-281487-x0a9qgjs 227 46 CT CT NNP cord-281487-x0a9qgjs 227 47 imaging imaging NN cord-281487-x0a9qgjs 227 48 findings finding NNS cord-281487-x0a9qgjs 227 49 Telemedicine Telemedicine NNP cord-281487-x0a9qgjs 227 50 for for IN cord-281487-x0a9qgjs 227 51 outpatient outpatient NN cord-281487-x0a9qgjs 227 52 neurosurgical neurosurgical JJ cord-281487-x0a9qgjs 227 53 oncology oncology NN cord-281487-x0a9qgjs 227 54 care care NN cord-281487-x0a9qgjs 227 55 : : : cord-281487-x0a9qgjs 227 56 lessons lesson NNS cord-281487-x0a9qgjs 227 57 learned learn VBN cord-281487-x0a9qgjs 227 58 for for IN cord-281487-x0a9qgjs 227 59 the the DT cord-281487-x0a9qgjs 227 60 future future NN cord-281487-x0a9qgjs 227 61 during during IN cord-281487-x0a9qgjs 227 62 the the DT cord-281487-x0a9qgjs 227 63 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 227 64 pandemic pandemic NN cord-281487-x0a9qgjs 227 65 Outpatient Outpatient NNP cord-281487-x0a9qgjs 227 66 Management Management NNP cord-281487-x0a9qgjs 227 67 of of IN cord-281487-x0a9qgjs 227 68 the the DT cord-281487-x0a9qgjs 227 69 Kidney Kidney NNP cord-281487-x0a9qgjs 227 70 Transplant Transplant NNP cord-281487-x0a9qgjs 227 71 Recipient Recipient NNP cord-281487-x0a9qgjs 227 72 during during IN cord-281487-x0a9qgjs 227 73 the the DT cord-281487-x0a9qgjs 227 74 SARS SARS NNP cord-281487-x0a9qgjs 227 75 - - HYPH cord-281487-x0a9qgjs 227 76 CoV-2 CoV-2 NNP cord-281487-x0a9qgjs 227 77 virus virus NN cord-281487-x0a9qgjs 227 78 pandemic pandemic NN cord-281487-x0a9qgjs 227 79 Out out IN cord-281487-x0a9qgjs 227 80 patient patient NN cord-281487-x0a9qgjs 227 81 department department NN cord-281487-x0a9qgjs 227 82 practices practice NNS cord-281487-x0a9qgjs 227 83 in in IN cord-281487-x0a9qgjs 227 84 orthopaedics orthopaedic NNS cord-281487-x0a9qgjs 227 85 amidst amidst IN cord-281487-x0a9qgjs 227 86 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 227 87 : : : cord-281487-x0a9qgjs 227 88 the the DT cord-281487-x0a9qgjs 227 89 evolving evolve VBG cord-281487-x0a9qgjs 227 90 model model NN cord-281487-x0a9qgjs 227 91 Care Care NNP cord-281487-x0a9qgjs 227 92 of of IN cord-281487-x0a9qgjs 227 93 patients patient NNS cord-281487-x0a9qgjs 227 94 with with IN cord-281487-x0a9qgjs 227 95 liver liver NN cord-281487-x0a9qgjs 227 96 disease disease NN cord-281487-x0a9qgjs 227 97 during during IN cord-281487-x0a9qgjs 227 98 the the DT cord-281487-x0a9qgjs 227 99 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 227 100 pandemic pandemic NN cord-281487-x0a9qgjs 227 101 : : : cord-281487-x0a9qgjs 227 102 EASL EASL NNP cord-281487-x0a9qgjs 227 103 - - HYPH cord-281487-x0a9qgjs 227 104 ESCMID ESCMID NNP cord-281487-x0a9qgjs 227 105 position position NN cord-281487-x0a9qgjs 227 106 paper paper NN cord-281487-x0a9qgjs 227 107 Cell cell NN cord-281487-x0a9qgjs 227 108 - - HYPH cord-281487-x0a9qgjs 227 109 free free JJ cord-281487-x0a9qgjs 227 110 DNA dna NN cord-281487-x0a9qgjs 227 111 and and CC cord-281487-x0a9qgjs 227 112 active active JJ cord-281487-x0a9qgjs 227 113 rejection rejection NN cord-281487-x0a9qgjs 227 114 in in IN cord-281487-x0a9qgjs 227 115 kidney kidney NN cord-281487-x0a9qgjs 227 116 allografts allograft NNS cord-281487-x0a9qgjs 227 117 Psychological psychological JJ cord-281487-x0a9qgjs 227 118 and and CC cord-281487-x0a9qgjs 227 119 psychopathological psychopathological JJ cord-281487-x0a9qgjs 227 120 aspects aspect NNS cord-281487-x0a9qgjs 227 121 of of IN cord-281487-x0a9qgjs 227 122 kidney kidney NN cord-281487-x0a9qgjs 227 123 transplantation transplantation NN cord-281487-x0a9qgjs 227 124 : : : cord-281487-x0a9qgjs 227 125 a a DT cord-281487-x0a9qgjs 227 126 systematic systematic JJ cord-281487-x0a9qgjs 227 127 review review NN cord-281487-x0a9qgjs 227 128 Therapeutic therapeutic JJ cord-281487-x0a9qgjs 227 129 algorithm algorithm NN cord-281487-x0a9qgjs 227 130 for for IN cord-281487-x0a9qgjs 227 131 use use NN cord-281487-x0a9qgjs 227 132 of of IN cord-281487-x0a9qgjs 227 133 melatonin melatonin NN cord-281487-x0a9qgjs 227 134 in in IN cord-281487-x0a9qgjs 227 135 patients patient NNS cord-281487-x0a9qgjs 227 136 with with IN cord-281487-x0a9qgjs 227 137 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 227 138 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 227 139 : : : cord-281487-x0a9qgjs 227 140 melatonin melatonin NN cord-281487-x0a9qgjs 227 141 as as IN cord-281487-x0a9qgjs 227 142 a a DT cord-281487-x0a9qgjs 227 143 potential potential JJ cord-281487-x0a9qgjs 227 144 adjuvant adjuvant NN cord-281487-x0a9qgjs 227 145 treatment treatment NN cord-281487-x0a9qgjs 227 146 AST AST NNP cord-281487-x0a9qgjs 227 147 . . . cord-281487-x0a9qgjs 228 1 2019-nCoV 2019-ncov CD cord-281487-x0a9qgjs 229 1 ( ( -LRB- cord-281487-x0a9qgjs 229 2 Coronavirus Coronavirus NNP cord-281487-x0a9qgjs 229 3 ) ) -RRB- cord-281487-x0a9qgjs 229 4 : : : cord-281487-x0a9qgjs 230 1 Recommendations recommendation NNS cord-281487-x0a9qgjs 230 2 and and CC cord-281487-x0a9qgjs 230 3 guidance guidance NN cord-281487-x0a9qgjs 230 4 for for IN cord-281487-x0a9qgjs 230 5 organ organ NN cord-281487-x0a9qgjs 230 6 donor donor NN cord-281487-x0a9qgjs 230 7 testing test VBG cord-281487-x0a9qgjs 230 8 Coronavirus Coronavirus NNP cord-281487-x0a9qgjs 230 9 disease disease NN cord-281487-x0a9qgjs 231 1 2019 2019 CD cord-281487-x0a9qgjs 231 2 pneumonia pneumonia NN cord-281487-x0a9qgjs 231 3 in in IN cord-281487-x0a9qgjs 231 4 immunosuppressed immunosuppressed JJ cord-281487-x0a9qgjs 231 5 renal renal JJ cord-281487-x0a9qgjs 231 6 transplant transplant NN cord-281487-x0a9qgjs 231 7 recipients recipient NNS cord-281487-x0a9qgjs 231 8 : : : cord-281487-x0a9qgjs 231 9 a a DT cord-281487-x0a9qgjs 231 10 summary summary NN cord-281487-x0a9qgjs 231 11 of of IN cord-281487-x0a9qgjs 231 12 10 10 CD cord-281487-x0a9qgjs 231 13 confirmed confirm VBN cord-281487-x0a9qgjs 231 14 cases case NNS cord-281487-x0a9qgjs 231 15 in in IN cord-281487-x0a9qgjs 231 16 Wuhan Wuhan NNP cord-281487-x0a9qgjs 231 17 , , , cord-281487-x0a9qgjs 231 18 China China NNP cord-281487-x0a9qgjs 232 1 The the DT cord-281487-x0a9qgjs 232 2 natural natural JJ cord-281487-x0a9qgjs 232 3 history history NN cord-281487-x0a9qgjs 232 4 of of IN cord-281487-x0a9qgjs 232 5 influenza influenza NN cord-281487-x0a9qgjs 232 6 infection infection NN cord-281487-x0a9qgjs 232 7 in in IN cord-281487-x0a9qgjs 232 8 the the DT cord-281487-x0a9qgjs 232 9 severely severely RB cord-281487-x0a9qgjs 232 10 immunocompromised immunocompromised JJ cord-281487-x0a9qgjs 232 11 vs vs IN cord-281487-x0a9qgjs 232 12 nonimmunocompromised nonimmunocompromised JJ cord-281487-x0a9qgjs 232 13 hosts host NNS cord-281487-x0a9qgjs 232 14 COVID-19 covid-19 VBP cord-281487-x0a9qgjs 232 15 illness illness NN cord-281487-x0a9qgjs 232 16 in in IN cord-281487-x0a9qgjs 232 17 native native JJ cord-281487-x0a9qgjs 232 18 and and CC cord-281487-x0a9qgjs 232 19 immunosuppressed immunosuppressed JJ cord-281487-x0a9qgjs 232 20 states state NNS cord-281487-x0a9qgjs 232 21 : : : cord-281487-x0a9qgjs 232 22 a a DT cord-281487-x0a9qgjs 232 23 clinical clinical JJ cord-281487-x0a9qgjs 232 24 - - HYPH cord-281487-x0a9qgjs 232 25 therapeutic therapeutic JJ cord-281487-x0a9qgjs 232 26 staging staging NN cord-281487-x0a9qgjs 232 27 proposal proposal NN cord-281487-x0a9qgjs 232 28 Clinical clinical JJ cord-281487-x0a9qgjs 232 29 predictors predictor NNS cord-281487-x0a9qgjs 232 30 of of IN cord-281487-x0a9qgjs 232 31 mortality mortality NN cord-281487-x0a9qgjs 232 32 due due IN cord-281487-x0a9qgjs 232 33 to to IN cord-281487-x0a9qgjs 232 34 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 232 35 based base VBN cord-281487-x0a9qgjs 232 36 on on IN cord-281487-x0a9qgjs 232 37 an an DT cord-281487-x0a9qgjs 232 38 analysis analysis NN cord-281487-x0a9qgjs 232 39 of of IN cord-281487-x0a9qgjs 232 40 data datum NNS cord-281487-x0a9qgjs 232 41 of of IN cord-281487-x0a9qgjs 232 42 150 150 CD cord-281487-x0a9qgjs 232 43 patients patient NNS cord-281487-x0a9qgjs 232 44 from from IN cord-281487-x0a9qgjs 232 45 Wuhan Wuhan NNP cord-281487-x0a9qgjs 232 46 , , , cord-281487-x0a9qgjs 232 47 China China NNP cord-281487-x0a9qgjs 232 48 Intensive Intensive NNP cord-281487-x0a9qgjs 232 49 care care NN cord-281487-x0a9qgjs 232 50 management management NN cord-281487-x0a9qgjs 232 51 of of IN cord-281487-x0a9qgjs 232 52 coronavirus coronavirus NN cord-281487-x0a9qgjs 232 53 disease disease NNP cord-281487-x0a9qgjs 232 54 2019 2019 CD cord-281487-x0a9qgjs 232 55 ( ( -LRB- cord-281487-x0a9qgjs 232 56 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 232 57 ) ) -RRB- cord-281487-x0a9qgjs 232 58 : : : cord-281487-x0a9qgjs 232 59 challenges challenge NNS cord-281487-x0a9qgjs 232 60 and and CC cord-281487-x0a9qgjs 232 61 recommendations recommendation NNS cord-281487-x0a9qgjs 233 1 Novel novel JJ cord-281487-x0a9qgjs 233 2 2019 2019 CD cord-281487-x0a9qgjs 233 3 coronavirus coronavirus NN cord-281487-x0a9qgjs 233 4 SARS SARS NNP cord-281487-x0a9qgjs 233 5 - - HYPH cord-281487-x0a9qgjs 233 6 CoV-2 CoV-2 NNP cord-281487-x0a9qgjs 233 7 ( ( -LRB- cord-281487-x0a9qgjs 233 8 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 233 9 ) ) -RRB- cord-281487-x0a9qgjs 233 10 : : : cord-281487-x0a9qgjs 234 1 an an DT cord-281487-x0a9qgjs 234 2 updated update VBN cord-281487-x0a9qgjs 234 3 overview overview NN cord-281487-x0a9qgjs 234 4 for for IN cord-281487-x0a9qgjs 234 5 emergency emergency NN cord-281487-x0a9qgjs 234 6 clinicians clinicians NNPS cord-281487-x0a9qgjs 234 7 Association Association NNP cord-281487-x0a9qgjs 234 8 of of IN cord-281487-x0a9qgjs 234 9 angiotensin angiotensin NN cord-281487-x0a9qgjs 234 10 - - HYPH cord-281487-x0a9qgjs 234 11 converting convert VBG cord-281487-x0a9qgjs 234 12 enzyme enzyme NN cord-281487-x0a9qgjs 234 13 inhibitor inhibitor NN cord-281487-x0a9qgjs 234 14 or or CC cord-281487-x0a9qgjs 234 15 angiotensin angiotensin NN cord-281487-x0a9qgjs 234 16 receptor receptor NN cord-281487-x0a9qgjs 234 17 blocker blocker NN cord-281487-x0a9qgjs 234 18 use use NN cord-281487-x0a9qgjs 234 19 with with IN cord-281487-x0a9qgjs 234 20 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 234 21 diagnosis diagnosis NN cord-281487-x0a9qgjs 234 22 and and CC cord-281487-x0a9qgjs 234 23 mortality mortality NN cord-281487-x0a9qgjs 234 24 Association Association NNP cord-281487-x0a9qgjs 234 25 of of IN cord-281487-x0a9qgjs 234 26 Inpatient Inpatient NNP cord-281487-x0a9qgjs 234 27 use use NN cord-281487-x0a9qgjs 234 28 of of IN cord-281487-x0a9qgjs 234 29 angiotensin angiotensin NN cord-281487-x0a9qgjs 234 30 - - HYPH cord-281487-x0a9qgjs 234 31 converting convert VBG cord-281487-x0a9qgjs 234 32 enzyme enzyme NN cord-281487-x0a9qgjs 234 33 inhibitors inhibitor NNS cord-281487-x0a9qgjs 234 34 and and CC cord-281487-x0a9qgjs 234 35 angiotensin angiotensin NN cord-281487-x0a9qgjs 234 36 II ii CD cord-281487-x0a9qgjs 234 37 receptor receptor NN cord-281487-x0a9qgjs 234 38 blockers blocker NNS cord-281487-x0a9qgjs 234 39 with with IN cord-281487-x0a9qgjs 234 40 mortality mortality NN cord-281487-x0a9qgjs 234 41 among among IN cord-281487-x0a9qgjs 234 42 patients patient NNS cord-281487-x0a9qgjs 234 43 with with IN cord-281487-x0a9qgjs 234 44 hypertension hypertension NN cord-281487-x0a9qgjs 234 45 hospitalized hospitalize VBN cord-281487-x0a9qgjs 234 46 with with IN cord-281487-x0a9qgjs 234 47 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 234 48 Effect Effect NNP cord-281487-x0a9qgjs 234 49 of of IN cord-281487-x0a9qgjs 234 50 maintenance maintenance NN cord-281487-x0a9qgjs 234 51 immunosuppressive immunosuppressive JJ cord-281487-x0a9qgjs 234 52 drugs drug NNS cord-281487-x0a9qgjs 234 53 on on IN cord-281487-x0a9qgjs 234 54 virus virus NN cord-281487-x0a9qgjs 234 55 pathobiology pathobiology NN cord-281487-x0a9qgjs 234 56 : : : cord-281487-x0a9qgjs 234 57 evidence evidence NN cord-281487-x0a9qgjs 234 58 and and CC cord-281487-x0a9qgjs 234 59 potential potential JJ cord-281487-x0a9qgjs 234 60 mechanisms mechanism NNS cord-281487-x0a9qgjs 234 61 Suppression suppression NN cord-281487-x0a9qgjs 234 62 of of IN cord-281487-x0a9qgjs 234 63 coronavirus coronavirus NN cord-281487-x0a9qgjs 234 64 replication replication NN cord-281487-x0a9qgjs 234 65 by by IN cord-281487-x0a9qgjs 234 66 cyclophilin cyclophilin NNP cord-281487-x0a9qgjs 234 67 inhibitors inhibitors NNP cord-281487-x0a9qgjs 234 68 COVID-19 covid-19 VBP cord-281487-x0a9qgjs 234 69 and and CC cord-281487-x0a9qgjs 234 70 calcineurin calcineurin NNP cord-281487-x0a9qgjs 234 71 inhibitors inhibitor NNS cord-281487-x0a9qgjs 234 72 : : : cord-281487-x0a9qgjs 234 73 should should MD cord-281487-x0a9qgjs 234 74 they -PRON- PRP cord-281487-x0a9qgjs 234 75 get get VB cord-281487-x0a9qgjs 234 76 left leave VBN cord-281487-x0a9qgjs 234 77 out out RP cord-281487-x0a9qgjs 234 78 in in IN cord-281487-x0a9qgjs 234 79 the the DT cord-281487-x0a9qgjs 234 80 storm storm NN cord-281487-x0a9qgjs 234 81 ? ? . cord-281487-x0a9qgjs 235 1 Replication replication NN cord-281487-x0a9qgjs 235 2 of of IN cord-281487-x0a9qgjs 235 3 human human JJ cord-281487-x0a9qgjs 235 4 coronaviruses coronaviruse NNS cord-281487-x0a9qgjs 235 5 SARS SARS NNP cord-281487-x0a9qgjs 235 6 - - HYPH cord-281487-x0a9qgjs 235 7 CoV CoV NNP cord-281487-x0a9qgjs 235 8 , , , cord-281487-x0a9qgjs 235 9 HCoV HCoV NNP cord-281487-x0a9qgjs 235 10 - - HYPH cord-281487-x0a9qgjs 235 11 NL63 NL63 NNP cord-281487-x0a9qgjs 235 12 and and CC cord-281487-x0a9qgjs 235 13 HCoV-229E HCoV-229E NNP cord-281487-x0a9qgjs 235 14 is be VBZ cord-281487-x0a9qgjs 235 15 inhibited inhibit VBN cord-281487-x0a9qgjs 235 16 by by IN cord-281487-x0a9qgjs 235 17 the the DT cord-281487-x0a9qgjs 235 18 drug drug NN cord-281487-x0a9qgjs 235 19 FK506 fk506 XX cord-281487-x0a9qgjs 235 20 COVID-19 covid-19 NN cord-281487-x0a9qgjs 235 21 : : : cord-281487-x0a9qgjs 235 22 implications implication NNS cord-281487-x0a9qgjs 235 23 for for IN cord-281487-x0a9qgjs 235 24 immunosuppression immunosuppression NN cord-281487-x0a9qgjs 235 25 in in IN cord-281487-x0a9qgjs 235 26 kidney kidney NN cord-281487-x0a9qgjs 235 27 disease disease NN cord-281487-x0a9qgjs 235 28 and and CC cord-281487-x0a9qgjs 235 29 transplantation transplantation NN cord-281487-x0a9qgjs 235 30 Dexamethasone Dexamethasone NNP cord-281487-x0a9qgjs 235 31 in in IN cord-281487-x0a9qgjs 235 32 hospitalized hospitalize VBN cord-281487-x0a9qgjs 235 33 patients patient NNS cord-281487-x0a9qgjs 235 34 with with IN cord-281487-x0a9qgjs 235 35 Covid-19-preliminary Covid-19-preliminary NNP cord-281487-x0a9qgjs 235 36 report report NN cord-281487-x0a9qgjs 235 37 Impact Impact NNP cord-281487-x0a9qgjs 235 38 of of IN cord-281487-x0a9qgjs 235 39 prophylactic prophylactic JJ cord-281487-x0a9qgjs 235 40 versus versus IN cord-281487-x0a9qgjs 235 41 preemptive preemptive JJ cord-281487-x0a9qgjs 235 42 valganciclovir valganciclovir NN cord-281487-x0a9qgjs 235 43 on on IN cord-281487-x0a9qgjs 235 44 long long JJ cord-281487-x0a9qgjs 235 45 - - HYPH cord-281487-x0a9qgjs 235 46 term term NN cord-281487-x0a9qgjs 235 47 renal renal JJ cord-281487-x0a9qgjs 235 48 allograft allograft NN cord-281487-x0a9qgjs 235 49 outcomes outcome NNS cord-281487-x0a9qgjs 235 50 Prevention Prevention NNP cord-281487-x0a9qgjs 235 51 and and CC cord-281487-x0a9qgjs 235 52 management management NN cord-281487-x0a9qgjs 235 53 of of IN cord-281487-x0a9qgjs 235 54 cytomegalovirus cytomegalovirus JJ cord-281487-x0a9qgjs 235 55 infection infection NN cord-281487-x0a9qgjs 235 56 in in IN cord-281487-x0a9qgjs 235 57 solid solid JJ cord-281487-x0a9qgjs 235 58 - - HYPH cord-281487-x0a9qgjs 235 59 organ organ NN cord-281487-x0a9qgjs 235 60 transplantation transplantation NN cord-281487-x0a9qgjs 235 61 Community community NN cord-281487-x0a9qgjs 235 62 - - HYPH cord-281487-x0a9qgjs 235 63 acquired acquire VBN cord-281487-x0a9qgjs 235 64 respiratory respiratory JJ cord-281487-x0a9qgjs 235 65 viruses virus NNS cord-281487-x0a9qgjs 235 66 are be VBP cord-281487-x0a9qgjs 235 67 a a DT cord-281487-x0a9qgjs 235 68 risk risk NN cord-281487-x0a9qgjs 235 69 factor factor NN cord-281487-x0a9qgjs 235 70 for for IN cord-281487-x0a9qgjs 235 71 chronic chronic JJ cord-281487-x0a9qgjs 235 72 lung lung NN cord-281487-x0a9qgjs 235 73 allograft allograft NN cord-281487-x0a9qgjs 235 74 dysfunction dysfunction NN cord-281487-x0a9qgjs 235 75 Respiratory respiratory JJ cord-281487-x0a9qgjs 235 76 viral viral JJ cord-281487-x0a9qgjs 235 77 infection infection NN cord-281487-x0a9qgjs 235 78 in in IN cord-281487-x0a9qgjs 235 79 lung lung NN cord-281487-x0a9qgjs 235 80 transplantation transplantation NN cord-281487-x0a9qgjs 235 81 induces induce VBZ cord-281487-x0a9qgjs 235 82 exosomes exosome NNS cord-281487-x0a9qgjs 235 83 that that IN cord-281487-x0a9qgjs 235 84 trigger trigger NN cord-281487-x0a9qgjs 235 85 chronic chronic JJ cord-281487-x0a9qgjs 235 86 rejection rejection NN cord-281487-x0a9qgjs 235 87 Polyomavirus Polyomavirus NNP cord-281487-x0a9qgjs 235 88 reactivation reactivation NN cord-281487-x0a9qgjs 235 89 and and CC cord-281487-x0a9qgjs 235 90 immune immune JJ cord-281487-x0a9qgjs 235 91 responses response NNS cord-281487-x0a9qgjs 235 92 to to IN cord-281487-x0a9qgjs 235 93 kidney kidney NN cord-281487-x0a9qgjs 235 94 - - HYPH cord-281487-x0a9qgjs 235 95 specific specific JJ cord-281487-x0a9qgjs 235 96 self self NN cord-281487-x0a9qgjs 235 97 - - HYPH cord-281487-x0a9qgjs 235 98 antigens antigen NNS cord-281487-x0a9qgjs 235 99 in in IN cord-281487-x0a9qgjs 236 1 transplantation transplantation NNP cord-281487-x0a9qgjs 236 2 BKvirus BKvirus NNP cord-281487-x0a9qgjs 236 3 and and CC cord-281487-x0a9qgjs 236 4 the the DT cord-281487-x0a9qgjs 236 5 impact impact NN cord-281487-x0a9qgjs 236 6 of of IN cord-281487-x0a9qgjs 236 7 pre pre JJ cord-281487-x0a9qgjs 236 8 - - JJ cord-281487-x0a9qgjs 236 9 emptive emptive JJ cord-281487-x0a9qgjs 236 10 immunosuppression immunosuppression NN cord-281487-x0a9qgjs 236 11 reduction reduction NN cord-281487-x0a9qgjs 236 12 : : : cord-281487-x0a9qgjs 237 1 5-year 5-year CD cord-281487-x0a9qgjs 237 2 results result NNS cord-281487-x0a9qgjs 238 1 Serum serum NN cord-281487-x0a9qgjs 238 2 vitamin vitamin NN cord-281487-x0a9qgjs 238 3 D d NN cord-281487-x0a9qgjs 238 4 levels level NNS cord-281487-x0a9qgjs 238 5 in in IN cord-281487-x0a9qgjs 238 6 kidney kidney NN cord-281487-x0a9qgjs 238 7 transplant transplant NN cord-281487-x0a9qgjs 238 8 recipients recipient NNS cord-281487-x0a9qgjs 238 9 : : : cord-281487-x0a9qgjs 238 10 the the DT cord-281487-x0a9qgjs 238 11 importance importance NN cord-281487-x0a9qgjs 238 12 of of IN cord-281487-x0a9qgjs 238 13 an an DT cord-281487-x0a9qgjs 238 14 immunosuppression immunosuppression NN cord-281487-x0a9qgjs 238 15 regimen regimen NN cord-281487-x0a9qgjs 238 16 and and CC cord-281487-x0a9qgjs 238 17 sun sun NN cord-281487-x0a9qgjs 238 18 exposure exposure NN cord-281487-x0a9qgjs 239 1 Current current JJ cord-281487-x0a9qgjs 239 2 evidence evidence NN cord-281487-x0a9qgjs 239 3 on on IN cord-281487-x0a9qgjs 239 4 vitamin vitamin NN cord-281487-x0a9qgjs 239 5 D d NN cord-281487-x0a9qgjs 239 6 deficiency deficiency NN cord-281487-x0a9qgjs 239 7 and and CC cord-281487-x0a9qgjs 239 8 kidney kidney NN cord-281487-x0a9qgjs 239 9 transplant transplant NN cord-281487-x0a9qgjs 239 10 : : : cord-281487-x0a9qgjs 239 11 what what WP cord-281487-x0a9qgjs 239 12 's be VBZ cord-281487-x0a9qgjs 239 13 new new JJ cord-281487-x0a9qgjs 239 14 ? ? . cord-281487-x0a9qgjs 240 1 Low low JJ cord-281487-x0a9qgjs 240 2 vitamin vitamin NN cord-281487-x0a9qgjs 240 3 D d NN cord-281487-x0a9qgjs 240 4 exposure exposure NN cord-281487-x0a9qgjs 240 5 is be VBZ cord-281487-x0a9qgjs 240 6 associated associate VBN cord-281487-x0a9qgjs 240 7 with with IN cord-281487-x0a9qgjs 240 8 higher high JJR cord-281487-x0a9qgjs 240 9 risk risk NN cord-281487-x0a9qgjs 240 10 of of IN cord-281487-x0a9qgjs 240 11 infection infection NN cord-281487-x0a9qgjs 240 12 in in IN cord-281487-x0a9qgjs 240 13 renal renal JJ cord-281487-x0a9qgjs 240 14 transplant transplant NN cord-281487-x0a9qgjs 240 15 recipients recipient NNS cord-281487-x0a9qgjs 241 1 The the DT cord-281487-x0a9qgjs 241 2 association association NN cord-281487-x0a9qgjs 241 3 of of IN cord-281487-x0a9qgjs 241 4 25-hydroxyvitamin 25-hydroxyvitamin CD cord-281487-x0a9qgjs 241 5 D D NNP cord-281487-x0a9qgjs 241 6 levels level NNS cord-281487-x0a9qgjs 241 7 with with IN cord-281487-x0a9qgjs 241 8 late late JJ cord-281487-x0a9qgjs 241 9 cytomegalovirus cytomegalovirus JJ cord-281487-x0a9qgjs 241 10 infection infection NN cord-281487-x0a9qgjs 241 11 in in IN cord-281487-x0a9qgjs 241 12 kidney kidney NN cord-281487-x0a9qgjs 241 13 transplant transplant NN cord-281487-x0a9qgjs 241 14 recipients recipient NNS cord-281487-x0a9qgjs 241 15 : : : cord-281487-x0a9qgjs 241 16 the the DT cord-281487-x0a9qgjs 241 17 Wisconsin Wisconsin NNP cord-281487-x0a9qgjs 241 18 Allograft Allograft NNP cord-281487-x0a9qgjs 241 19 Recipient Recipient NNP cord-281487-x0a9qgjs 241 20 Database Database NNP cord-281487-x0a9qgjs 241 21 Acute acute JJ cord-281487-x0a9qgjs 241 22 respiratory respiratory JJ cord-281487-x0a9qgjs 241 23 tract tract NN cord-281487-x0a9qgjs 241 24 infection infection NN cord-281487-x0a9qgjs 241 25 and and CC cord-281487-x0a9qgjs 241 26 25-hydroxyvitamin 25-hydroxyvitamin CD cord-281487-x0a9qgjs 241 27 D d NN cord-281487-x0a9qgjs 241 28 concentration concentration NN cord-281487-x0a9qgjs 241 29 : : : cord-281487-x0a9qgjs 241 30 a a DT cord-281487-x0a9qgjs 241 31 systematic systematic JJ cord-281487-x0a9qgjs 241 32 review review NN cord-281487-x0a9qgjs 241 33 and and CC cord-281487-x0a9qgjs 241 34 meta meta NNP cord-281487-x0a9qgjs 241 35 - - HYPH cord-281487-x0a9qgjs 241 36 analysis analysis NN cord-281487-x0a9qgjs 241 37 Vitamin vitamin NN cord-281487-x0a9qgjs 241 38 D d NN cord-281487-x0a9qgjs 241 39 and and CC cord-281487-x0a9qgjs 241 40 critical critical JJ cord-281487-x0a9qgjs 241 41 illness illness NN cord-281487-x0a9qgjs 241 42 : : : cord-281487-x0a9qgjs 241 43 what what WP cord-281487-x0a9qgjs 241 44 endocrinology endocrinology NN cord-281487-x0a9qgjs 241 45 can can MD cord-281487-x0a9qgjs 241 46 learn learn VB cord-281487-x0a9qgjs 241 47 from from IN cord-281487-x0a9qgjs 241 48 intensive intensive JJ cord-281487-x0a9qgjs 241 49 care care NN cord-281487-x0a9qgjs 241 50 and and CC cord-281487-x0a9qgjs 241 51 vice vice NN cord-281487-x0a9qgjs 241 52 versa versa RB cord-281487-x0a9qgjs 241 53 High high JJ cord-281487-x0a9qgjs 241 54 dose dose NN cord-281487-x0a9qgjs 241 55 vitamin vitamin NN cord-281487-x0a9qgjs 241 56 D D NNP cord-281487-x0a9qgjs 241 57 administration administration NN cord-281487-x0a9qgjs 241 58 in in IN cord-281487-x0a9qgjs 241 59 ventilated ventilate VBN cord-281487-x0a9qgjs 241 60 intensive intensive JJ cord-281487-x0a9qgjs 241 61 care care NN cord-281487-x0a9qgjs 241 62 unit unit NN cord-281487-x0a9qgjs 241 63 patients patient NNS cord-281487-x0a9qgjs 241 64 : : : cord-281487-x0a9qgjs 241 65 a a DT cord-281487-x0a9qgjs 241 66 pilot pilot NN cord-281487-x0a9qgjs 241 67 double double JJ cord-281487-x0a9qgjs 241 68 blind blind JJ cord-281487-x0a9qgjs 241 69 randomized randomized JJ cord-281487-x0a9qgjs 241 70 controlled control VBN cord-281487-x0a9qgjs 241 71 trial trial NN cord-281487-x0a9qgjs 241 72 Early early JJ cord-281487-x0a9qgjs 241 73 high high JJ cord-281487-x0a9qgjs 241 74 - - HYPH cord-281487-x0a9qgjs 241 75 dose dose NN cord-281487-x0a9qgjs 241 76 vitamin vitamin NN cord-281487-x0a9qgjs 241 77 D(3 d(3 NN cord-281487-x0a9qgjs 241 78 ) ) -RRB- cord-281487-x0a9qgjs 241 79 for for IN cord-281487-x0a9qgjs 241 80 critically critically RB cord-281487-x0a9qgjs 241 81 ill ill JJ cord-281487-x0a9qgjs 241 82 , , , cord-281487-x0a9qgjs 241 83 vitamin vitamin NN cord-281487-x0a9qgjs 241 84 D d NN cord-281487-x0a9qgjs 241 85 - - HYPH cord-281487-x0a9qgjs 241 86 deficient deficient JJ cord-281487-x0a9qgjs 241 87 patients patient NNS cord-281487-x0a9qgjs 241 88 Can Can MD cord-281487-x0a9qgjs 241 89 melatonin melatonin NN cord-281487-x0a9qgjs 241 90 reduce reduce VB cord-281487-x0a9qgjs 241 91 the the DT cord-281487-x0a9qgjs 241 92 severity severity NN cord-281487-x0a9qgjs 241 93 of of IN cord-281487-x0a9qgjs 241 94 COVID-19 covid-19 JJ cord-281487-x0a9qgjs 241 95 pandemic pandemic NN cord-281487-x0a9qgjs 241 96 ? ? . cord-281487-x0a9qgjs 242 1 Current current JJ cord-281487-x0a9qgjs 242 2 approaches approach NNS cord-281487-x0a9qgjs 242 3 in in IN cord-281487-x0a9qgjs 242 4 the the DT cord-281487-x0a9qgjs 242 5 grading grading NN cord-281487-x0a9qgjs 242 6 and and CC cord-281487-x0a9qgjs 242 7 management management NN cord-281487-x0a9qgjs 242 8 of of IN cord-281487-x0a9qgjs 242 9 cytokine cytokine NN cord-281487-x0a9qgjs 242 10 release release NN cord-281487-x0a9qgjs 242 11 syndrome syndrome NN cord-281487-x0a9qgjs 242 12 after after IN cord-281487-x0a9qgjs 242 13 chimeric chimeric JJ cord-281487-x0a9qgjs 242 14 antigen antigen NN cord-281487-x0a9qgjs 242 15 receptor receptor NN cord-281487-x0a9qgjs 242 16 T t NN cord-281487-x0a9qgjs 242 17 - - HYPH cord-281487-x0a9qgjs 242 18 cell cell NN cord-281487-x0a9qgjs 242 19 therapy therapy NN cord-281487-x0a9qgjs 242 20 Disruption disruption NN cord-281487-x0a9qgjs 242 21 of of IN cord-281487-x0a9qgjs 242 22 a a DT cord-281487-x0a9qgjs 242 23 self self NN cord-281487-x0a9qgjs 242 24 - - HYPH cord-281487-x0a9qgjs 242 25 amplifying amplify VBG cord-281487-x0a9qgjs 242 26 catecholamine catecholamine NN cord-281487-x0a9qgjs 242 27 loop loop NN cord-281487-x0a9qgjs 242 28 reduces reduce VBZ cord-281487-x0a9qgjs 242 29 cytokine cytokine NN cord-281487-x0a9qgjs 242 30 release release NN cord-281487-x0a9qgjs 242 31 syndrome syndrome NN cord-281487-x0a9qgjs 242 32 Alpha-1 alpha-1 JJ cord-281487-x0a9qgjs 242 33 adrenergic adrenergic JJ cord-281487-x0a9qgjs 242 34 receptor receptor NN cord-281487-x0a9qgjs 242 35 antagonists antagonist NNS cord-281487-x0a9qgjs 242 36 for for IN cord-281487-x0a9qgjs 242 37 preventing prevent VBG cord-281487-x0a9qgjs 242 38 acute acute JJ cord-281487-x0a9qgjs 242 39 respiratory respiratory JJ cord-281487-x0a9qgjs 242 40 distress distress NN cord-281487-x0a9qgjs 242 41 syndrome syndrome NN cord-281487-x0a9qgjs 242 42 and and CC cord-281487-x0a9qgjs 242 43 death death NN cord-281487-x0a9qgjs 242 44 from from IN cord-281487-x0a9qgjs 242 45 cytokine cytokine JJ cord-281487-x0a9qgjs 242 46 storm storm NN cord-281487-x0a9qgjs 242 47 syndrome syndrome NN cord-281487-x0a9qgjs 242 48 Preventing prevent VBG cord-281487-x0a9qgjs 242 49 cytokine cytokine NN cord-281487-x0a9qgjs 242 50 storm storm NN cord-281487-x0a9qgjs 242 51 syndrome syndrome NN cord-281487-x0a9qgjs 242 52 in in IN cord-281487-x0a9qgjs 242 53 COVID-19 COVID-19 NNP cord-281487-x0a9qgjs 242 54 using use VBG cord-281487-x0a9qgjs 242 55 α-1 α-1 JJ cord-281487-x0a9qgjs 242 56 adrenergic adrenergic JJ cord-281487-x0a9qgjs 242 57 receptor receptor NN cord-281487-x0a9qgjs 242 58 antagonists antagonist NNS cord-281487-x0a9qgjs 242 59 Publisher Publisher NNP cord-281487-x0a9qgjs 242 60 's 's POS cord-281487-x0a9qgjs 242 61 Note Note NNP cord-281487-x0a9qgjs 242 62 Springer Springer NNP cord-281487-x0a9qgjs 242 63 Nature Nature NNP cord-281487-x0a9qgjs 242 64 remains remain VBZ cord-281487-x0a9qgjs 242 65 neutral neutral JJ cord-281487-x0a9qgjs 242 66 with with IN cord-281487-x0a9qgjs 242 67 regard regard NN cord-281487-x0a9qgjs 242 68 to to IN cord-281487-x0a9qgjs 242 69 jurisdictional jurisdictional JJ cord-281487-x0a9qgjs 242 70 claims claim NNS cord-281487-x0a9qgjs 242 71 in in IN cord-281487-x0a9qgjs 242 72 published publish VBN cord-281487-x0a9qgjs 242 73 maps map NNS cord-281487-x0a9qgjs 242 74 and and CC cord-281487-x0a9qgjs 242 75 institutional institutional JJ cord-281487-x0a9qgjs 242 76 affiliations affiliation NNS cord-281487-x0a9qgjs 242 77 Conflict conflict NN cord-281487-x0a9qgjs 242 78 of of IN cord-281487-x0a9qgjs 242 79 Interest interest NN cord-281487-x0a9qgjs 243 1 The the DT cord-281487-x0a9qgjs 243 2 authors author NNS cord-281487-x0a9qgjs 243 3 declare declare VBP cord-281487-x0a9qgjs 243 4 that that IN cord-281487-x0a9qgjs 243 5 they -PRON- PRP cord-281487-x0a9qgjs 243 6 have have VBP cord-281487-x0a9qgjs 243 7 no no DT cord-281487-x0a9qgjs 243 8 conflict conflict NN cord-281487-x0a9qgjs 243 9 of of IN cord-281487-x0a9qgjs 243 10 interest interest NN cord-281487-x0a9qgjs 243 11 . . .