id sid tid token lemma pos cord-280642-cvxni7cd 1 1 key key NN cord-280642-cvxni7cd 1 2 : : : cord-280642-cvxni7cd 2 1 cord-280642-cvxni7cd cord-280642-cvxni7cd NNP cord-280642-cvxni7cd 2 2 authors author NNS cord-280642-cvxni7cd 2 3 : : : cord-280642-cvxni7cd 2 4 The the DT cord-280642-cvxni7cd 2 5 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 2 6 Collaborative Collaborative NNP cord-280642-cvxni7cd 2 7 , , , cord-280642-cvxni7cd 2 8 ; ; : cord-280642-cvxni7cd 2 9 Williamson Williamson NNP cord-280642-cvxni7cd 2 10 , , , cord-280642-cvxni7cd 2 11 E. E. NNP cord-280642-cvxni7cd 2 12 ; ; : cord-280642-cvxni7cd 2 13 Walker Walker NNP cord-280642-cvxni7cd 2 14 , , , cord-280642-cvxni7cd 2 15 A. a. NN cord-280642-cvxni7cd 2 16 J. J. NNP cord-280642-cvxni7cd 2 17 ; ; : cord-280642-cvxni7cd 2 18 Bhaskaran Bhaskaran NNP cord-280642-cvxni7cd 2 19 , , , cord-280642-cvxni7cd 2 20 K. K. NNP cord-280642-cvxni7cd 2 21 J. J. NNP cord-280642-cvxni7cd 2 22 ; ; : cord-280642-cvxni7cd 2 23 Bacon Bacon NNP cord-280642-cvxni7cd 2 24 , , , cord-280642-cvxni7cd 2 25 S. S. NNP cord-280642-cvxni7cd 2 26 ; ; : cord-280642-cvxni7cd 2 27 Bates Bates NNP cord-280642-cvxni7cd 2 28 , , , cord-280642-cvxni7cd 2 29 C. C. NNP cord-280642-cvxni7cd 2 30 ; ; : cord-280642-cvxni7cd 2 31 Morton Morton NNP cord-280642-cvxni7cd 2 32 , , , cord-280642-cvxni7cd 2 33 C. C. NNP cord-280642-cvxni7cd 2 34 E. E. NNP cord-280642-cvxni7cd 2 35 ; ; : cord-280642-cvxni7cd 2 36 Curtis Curtis NNP cord-280642-cvxni7cd 2 37 , , , cord-280642-cvxni7cd 2 38 H. H. NNP cord-280642-cvxni7cd 2 39 J. J. NNP cord-280642-cvxni7cd 2 40 ; ; : cord-280642-cvxni7cd 2 41 Mehrkar Mehrkar NNP cord-280642-cvxni7cd 2 42 , , , cord-280642-cvxni7cd 2 43 A. a. NN cord-280642-cvxni7cd 2 44 ; ; : cord-280642-cvxni7cd 2 45 Evans Evans NNP cord-280642-cvxni7cd 2 46 , , , cord-280642-cvxni7cd 2 47 D. D. NNP cord-280642-cvxni7cd 2 48 ; ; : cord-280642-cvxni7cd 2 49 Inglesby Inglesby NNP cord-280642-cvxni7cd 2 50 , , , cord-280642-cvxni7cd 2 51 P. P. NNP cord-280642-cvxni7cd 2 52 ; ; : cord-280642-cvxni7cd 2 53 Cockburn Cockburn NNP cord-280642-cvxni7cd 2 54 , , , cord-280642-cvxni7cd 2 55 J. J. NNP cord-280642-cvxni7cd 2 56 ; ; : cord-280642-cvxni7cd 2 57 Mcdonald Mcdonald NNP cord-280642-cvxni7cd 2 58 , , , cord-280642-cvxni7cd 2 59 H. H. NNP cord-280642-cvxni7cd 2 60 I. I. NNP cord-280642-cvxni7cd 2 61 ; ; , cord-280642-cvxni7cd 2 62 MacKenna MacKenna NNP cord-280642-cvxni7cd 2 63 , , , cord-280642-cvxni7cd 2 64 B. B. NNP cord-280642-cvxni7cd 2 65 ; ; : cord-280642-cvxni7cd 3 1 Tomlinson Tomlinson NNP cord-280642-cvxni7cd 3 2 , , , cord-280642-cvxni7cd 3 3 L. L. NNP cord-280642-cvxni7cd 3 4 ; ; : cord-280642-cvxni7cd 3 5 Douglas Douglas NNP cord-280642-cvxni7cd 3 6 , , , cord-280642-cvxni7cd 3 7 I. I. NNP cord-280642-cvxni7cd 3 8 J. J. NNP cord-280642-cvxni7cd 3 9 ; ; : cord-280642-cvxni7cd 3 10 Rentsch Rentsch NNP cord-280642-cvxni7cd 3 11 , , , cord-280642-cvxni7cd 3 12 C. C. NNP cord-280642-cvxni7cd 3 13 T. T. NNP cord-280642-cvxni7cd 3 14 ; ; : cord-280642-cvxni7cd 3 15 Mathur Mathur NNP cord-280642-cvxni7cd 3 16 , , , cord-280642-cvxni7cd 3 17 R. R. NNP cord-280642-cvxni7cd 3 18 ; ; : cord-280642-cvxni7cd 3 19 Wong Wong NNP cord-280642-cvxni7cd 3 20 , , , cord-280642-cvxni7cd 3 21 A. a. NN cord-280642-cvxni7cd 3 22 ; ; : cord-280642-cvxni7cd 3 23 Grieve grieve VB cord-280642-cvxni7cd 3 24 , , , cord-280642-cvxni7cd 3 25 R. R. NNP cord-280642-cvxni7cd 3 26 ; ; : cord-280642-cvxni7cd 3 27 Harrison Harrison NNP cord-280642-cvxni7cd 3 28 , , , cord-280642-cvxni7cd 3 29 D. D. NNP cord-280642-cvxni7cd 3 30 ; ; : cord-280642-cvxni7cd 3 31 Forbes Forbes NNP cord-280642-cvxni7cd 3 32 , , , cord-280642-cvxni7cd 3 33 H. H. NNP cord-280642-cvxni7cd 3 34 ; ; : cord-280642-cvxni7cd 3 35 Schultze Schultze NNP cord-280642-cvxni7cd 3 36 , , , cord-280642-cvxni7cd 3 37 A. a. NN cord-280642-cvxni7cd 3 38 ; ; : cord-280642-cvxni7cd 3 39 Croker Croker NNP cord-280642-cvxni7cd 3 40 , , , cord-280642-cvxni7cd 3 41 R. R. NNP cord-280642-cvxni7cd 3 42 T. T. NNP cord-280642-cvxni7cd 3 43 ; ; : cord-280642-cvxni7cd 3 44 Parry Parry NNP cord-280642-cvxni7cd 3 45 , , , cord-280642-cvxni7cd 3 46 J. J. NNP cord-280642-cvxni7cd 3 47 ; ; : cord-280642-cvxni7cd 3 48 Hester Hester NNP cord-280642-cvxni7cd 3 49 , , , cord-280642-cvxni7cd 3 50 F. F. NNP cord-280642-cvxni7cd 3 51 ; ; : cord-280642-cvxni7cd 3 52 Harper Harper NNP cord-280642-cvxni7cd 3 53 , , , cord-280642-cvxni7cd 3 54 S. S. NNP cord-280642-cvxni7cd 3 55 ; ; : cord-280642-cvxni7cd 3 56 Perera Perera NNP cord-280642-cvxni7cd 3 57 , , , cord-280642-cvxni7cd 3 58 R. R. NNP cord-280642-cvxni7cd 3 59 ; ; : cord-280642-cvxni7cd 3 60 Evans Evans NNP cord-280642-cvxni7cd 3 61 , , , cord-280642-cvxni7cd 3 62 S. S. NNP cord-280642-cvxni7cd 3 63 ; ; : cord-280642-cvxni7cd 3 64 Smeeth Smeeth NNP cord-280642-cvxni7cd 3 65 , , , cord-280642-cvxni7cd 3 66 L. L. NNP cord-280642-cvxni7cd 3 67 ; ; : cord-280642-cvxni7cd 3 68 Goldacre Goldacre NNP cord-280642-cvxni7cd 3 69 , , , cord-280642-cvxni7cd 3 70 B. B. NNP cord-280642-cvxni7cd 3 71 title title NN cord-280642-cvxni7cd 3 72 : : : cord-280642-cvxni7cd 3 73 OpenSAFELY opensafely NN cord-280642-cvxni7cd 3 74 : : : cord-280642-cvxni7cd 3 75 factors factor NNS cord-280642-cvxni7cd 3 76 associated associate VBN cord-280642-cvxni7cd 3 77 with with IN cord-280642-cvxni7cd 3 78 COVID-19-related covid-19-related JJ cord-280642-cvxni7cd 3 79 hospital hospital NN cord-280642-cvxni7cd 3 80 death death NN cord-280642-cvxni7cd 3 81 in in IN cord-280642-cvxni7cd 3 82 the the DT cord-280642-cvxni7cd 3 83 linked link VBN cord-280642-cvxni7cd 3 84 electronic electronic JJ cord-280642-cvxni7cd 3 85 health health NN cord-280642-cvxni7cd 3 86 records record NNS cord-280642-cvxni7cd 3 87 of of IN cord-280642-cvxni7cd 3 88 17 17 CD cord-280642-cvxni7cd 3 89 million million CD cord-280642-cvxni7cd 3 90 adult adult NN cord-280642-cvxni7cd 3 91 NHS NHS NNP cord-280642-cvxni7cd 3 92 patients patient NNS cord-280642-cvxni7cd 3 93 . . . cord-280642-cvxni7cd 4 1 date date NN cord-280642-cvxni7cd 4 2 : : : cord-280642-cvxni7cd 4 3 2020 2020 CD cord-280642-cvxni7cd 4 4 - - HYPH cord-280642-cvxni7cd 4 5 05 05 CD cord-280642-cvxni7cd 4 6 - - HYPH cord-280642-cvxni7cd 4 7 07 07 CD cord-280642-cvxni7cd 4 8 journal journal NN cord-280642-cvxni7cd 4 9 : : : cord-280642-cvxni7cd 5 1 nan nan NNP cord-280642-cvxni7cd 5 2 DOI DOI NNP cord-280642-cvxni7cd 5 3 : : : cord-280642-cvxni7cd 5 4 10.1101/2020.05.06.20092999 10.1101/2020.05.06.20092999 CD cord-280642-cvxni7cd 5 5 sha sha NNP cord-280642-cvxni7cd 5 6 : : : cord-280642-cvxni7cd 5 7 ac3e12fa34c6ec2e4e40ed22f391b18878dad0e9 ac3e12fa34c6ec2e4e40ed22f391b18878dad0e9 NNP cord-280642-cvxni7cd 5 8 doc_id doc_id CD cord-280642-cvxni7cd 5 9 : : : cord-280642-cvxni7cd 5 10 280642 280642 CD cord-280642-cvxni7cd 5 11 cord_uid cord_uid NNS cord-280642-cvxni7cd 5 12 : : : cord-280642-cvxni7cd 6 1 cvxni7cd cvxni7cd NNP cord-280642-cvxni7cd 6 2 Background Background NNP cord-280642-cvxni7cd 6 3 Establishing Establishing NNP cord-280642-cvxni7cd 6 4 who who WP cord-280642-cvxni7cd 6 5 is be VBZ cord-280642-cvxni7cd 6 6 at at IN cord-280642-cvxni7cd 6 7 risk risk NN cord-280642-cvxni7cd 6 8 from from IN cord-280642-cvxni7cd 6 9 a a DT cord-280642-cvxni7cd 6 10 novel novel NN cord-280642-cvxni7cd 6 11 rapidly rapidly RB cord-280642-cvxni7cd 6 12 arising arise VBG cord-280642-cvxni7cd 6 13 cause cause NN cord-280642-cvxni7cd 6 14 of of IN cord-280642-cvxni7cd 6 15 death death NN cord-280642-cvxni7cd 6 16 , , , cord-280642-cvxni7cd 6 17 and and CC cord-280642-cvxni7cd 6 18 why why WRB cord-280642-cvxni7cd 6 19 , , , cord-280642-cvxni7cd 6 20 requires require VBZ cord-280642-cvxni7cd 6 21 a a DT cord-280642-cvxni7cd 6 22 new new JJ cord-280642-cvxni7cd 6 23 approach approach NN cord-280642-cvxni7cd 6 24 to to IN cord-280642-cvxni7cd 6 25 epidemiological epidemiological JJ cord-280642-cvxni7cd 6 26 research research NN cord-280642-cvxni7cd 6 27 with with IN cord-280642-cvxni7cd 6 28 very very RB cord-280642-cvxni7cd 6 29 large large JJ cord-280642-cvxni7cd 6 30 datasets dataset NNS cord-280642-cvxni7cd 6 31 and and CC cord-280642-cvxni7cd 6 32 timely timely JJ cord-280642-cvxni7cd 6 33 data datum NNS cord-280642-cvxni7cd 6 34 . . . cord-280642-cvxni7cd 7 1 Working work VBG cord-280642-cvxni7cd 7 2 on on IN cord-280642-cvxni7cd 7 3 behalf behalf NN cord-280642-cvxni7cd 7 4 of of IN cord-280642-cvxni7cd 7 5 NHS NHS NNP cord-280642-cvxni7cd 7 6 England England NNP cord-280642-cvxni7cd 7 7 we -PRON- PRP cord-280642-cvxni7cd 7 8 therefore therefore RB cord-280642-cvxni7cd 7 9 set set VBD cord-280642-cvxni7cd 7 10 out out RP cord-280642-cvxni7cd 7 11 to to TO cord-280642-cvxni7cd 7 12 deliver deliver VB cord-280642-cvxni7cd 7 13 a a DT cord-280642-cvxni7cd 7 14 secure secure JJ cord-280642-cvxni7cd 7 15 and and CC cord-280642-cvxni7cd 7 16 pseudonymised pseudonymised JJ cord-280642-cvxni7cd 7 17 analytics analytics NNP cord-280642-cvxni7cd 7 18 platform platform NN cord-280642-cvxni7cd 7 19 inside inside IN cord-280642-cvxni7cd 7 20 the the DT cord-280642-cvxni7cd 7 21 data datum NNS cord-280642-cvxni7cd 7 22 centre centre NN cord-280642-cvxni7cd 7 23 of of IN cord-280642-cvxni7cd 7 24 a a DT cord-280642-cvxni7cd 7 25 major major JJ cord-280642-cvxni7cd 7 26 primary primary JJ cord-280642-cvxni7cd 7 27 care care NN cord-280642-cvxni7cd 7 28 electronic electronic JJ cord-280642-cvxni7cd 7 29 health health NN cord-280642-cvxni7cd 7 30 records record NNS cord-280642-cvxni7cd 7 31 vendor vendor NN cord-280642-cvxni7cd 7 32 establishing establish VBG cord-280642-cvxni7cd 7 33 coverage coverage NN cord-280642-cvxni7cd 7 34 across across IN cord-280642-cvxni7cd 7 35 detailed detailed JJ cord-280642-cvxni7cd 7 36 primary primary JJ cord-280642-cvxni7cd 7 37 care care NN cord-280642-cvxni7cd 7 38 records record NNS cord-280642-cvxni7cd 7 39 for for IN cord-280642-cvxni7cd 7 40 a a DT cord-280642-cvxni7cd 7 41 substantial substantial JJ cord-280642-cvxni7cd 7 42 proportion proportion NN cord-280642-cvxni7cd 7 43 of of IN cord-280642-cvxni7cd 7 44 all all DT cord-280642-cvxni7cd 7 45 patients patient NNS cord-280642-cvxni7cd 7 46 in in IN cord-280642-cvxni7cd 7 47 England England NNP cord-280642-cvxni7cd 7 48 . . . cord-280642-cvxni7cd 8 1 The the DT cord-280642-cvxni7cd 8 2 following following JJ cord-280642-cvxni7cd 8 3 results result NNS cord-280642-cvxni7cd 8 4 are be VBP cord-280642-cvxni7cd 8 5 preliminary preliminary JJ cord-280642-cvxni7cd 8 6 . . . cord-280642-cvxni7cd 9 1 Data datum NNS cord-280642-cvxni7cd 9 2 sources source NNS cord-280642-cvxni7cd 10 1 Primary primary JJ cord-280642-cvxni7cd 10 2 care care NN cord-280642-cvxni7cd 10 3 electronic electronic JJ cord-280642-cvxni7cd 10 4 health health NN cord-280642-cvxni7cd 10 5 records record NNS cord-280642-cvxni7cd 10 6 managed manage VBN cord-280642-cvxni7cd 10 7 by by IN cord-280642-cvxni7cd 10 8 the the DT cord-280642-cvxni7cd 10 9 electronic electronic JJ cord-280642-cvxni7cd 10 10 health health NN cord-280642-cvxni7cd 10 11 record record NN cord-280642-cvxni7cd 10 12 vendor vendor NN cord-280642-cvxni7cd 10 13 TPP TPP NNP cord-280642-cvxni7cd 10 14 , , , cord-280642-cvxni7cd 10 15 pseudonymously pseudonymously RB cord-280642-cvxni7cd 10 16 linked link VBN cord-280642-cvxni7cd 10 17 to to IN cord-280642-cvxni7cd 10 18 patient patient JJ cord-280642-cvxni7cd 10 19 - - HYPH cord-280642-cvxni7cd 10 20 level level NN cord-280642-cvxni7cd 10 21 data datum NNS cord-280642-cvxni7cd 10 22 from from IN cord-280642-cvxni7cd 10 23 the the DT cord-280642-cvxni7cd 10 24 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 10 25 Patient Patient NNP cord-280642-cvxni7cd 10 26 Notification Notification NNP cord-280642-cvxni7cd 10 27 System System NNP cord-280642-cvxni7cd 10 28 ( ( -LRB- cord-280642-cvxni7cd 10 29 CPNS CPNS NNP cord-280642-cvxni7cd 10 30 ) ) -RRB- cord-280642-cvxni7cd 10 31 for for IN cord-280642-cvxni7cd 10 32 death death NN cord-280642-cvxni7cd 10 33 of of IN cord-280642-cvxni7cd 10 34 hospital hospital NN cord-280642-cvxni7cd 10 35 inpatients inpatient NNS cord-280642-cvxni7cd 10 36 with with IN cord-280642-cvxni7cd 10 37 confirmed confirm VBN cord-280642-cvxni7cd 10 38 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 10 39 , , , cord-280642-cvxni7cd 10 40 using use VBG cord-280642-cvxni7cd 10 41 the the DT cord-280642-cvxni7cd 10 42 new new JJ cord-280642-cvxni7cd 10 43 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 10 44 platform platform NN cord-280642-cvxni7cd 10 45 . . . cord-280642-cvxni7cd 11 1 Population population NN cord-280642-cvxni7cd 11 2 17,425,445 17,425,445 CD cord-280642-cvxni7cd 11 3 adults adult NNS cord-280642-cvxni7cd 11 4 . . . cord-280642-cvxni7cd 12 1 Time time NN cord-280642-cvxni7cd 12 2 period period NN cord-280642-cvxni7cd 12 3 1st 1st JJ cord-280642-cvxni7cd 12 4 Feb Feb NNP cord-280642-cvxni7cd 12 5 2020 2020 CD cord-280642-cvxni7cd 12 6 to to IN cord-280642-cvxni7cd 12 7 25th 25th JJ cord-280642-cvxni7cd 12 8 April April NNP cord-280642-cvxni7cd 12 9 2020 2020 CD cord-280642-cvxni7cd 12 10 . . . cord-280642-cvxni7cd 13 1 Primary primary JJ cord-280642-cvxni7cd 13 2 outcome outcome NN cord-280642-cvxni7cd 13 3 Death death NN cord-280642-cvxni7cd 13 4 in in IN cord-280642-cvxni7cd 13 5 hospital hospital NN cord-280642-cvxni7cd 13 6 among among IN cord-280642-cvxni7cd 13 7 people people NNS cord-280642-cvxni7cd 13 8 with with IN cord-280642-cvxni7cd 13 9 confirmed confirm VBN cord-280642-cvxni7cd 13 10 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 13 11 . . . cord-280642-cvxni7cd 14 1 Methods Methods NNPS cord-280642-cvxni7cd 14 2 Cohort Cohort NNP cord-280642-cvxni7cd 14 3 study study NN cord-280642-cvxni7cd 14 4 analysed analyse VBN cord-280642-cvxni7cd 14 5 by by IN cord-280642-cvxni7cd 14 6 Cox Cox NNP cord-280642-cvxni7cd 14 7 - - HYPH cord-280642-cvxni7cd 14 8 regression regression NN cord-280642-cvxni7cd 14 9 to to TO cord-280642-cvxni7cd 14 10 generate generate VB cord-280642-cvxni7cd 14 11 hazard hazard NN cord-280642-cvxni7cd 14 12 ratios ratio NNS cord-280642-cvxni7cd 14 13 : : : cord-280642-cvxni7cd 14 14 age age NN cord-280642-cvxni7cd 14 15 and and CC cord-280642-cvxni7cd 14 16 sex sex NN cord-280642-cvxni7cd 14 17 adjusted adjust VBN cord-280642-cvxni7cd 14 18 , , , cord-280642-cvxni7cd 14 19 and and CC cord-280642-cvxni7cd 14 20 multiply multiply VB cord-280642-cvxni7cd 14 21 adjusted adjust VBN cord-280642-cvxni7cd 14 22 for for IN cord-280642-cvxni7cd 14 23 co co NNS cord-280642-cvxni7cd 14 24 - - JJ cord-280642-cvxni7cd 14 25 variates variate NNS cord-280642-cvxni7cd 14 26 selected select VBN cord-280642-cvxni7cd 14 27 prospectively prospectively RB cord-280642-cvxni7cd 14 28 on on IN cord-280642-cvxni7cd 14 29 the the DT cord-280642-cvxni7cd 14 30 basis basis NN cord-280642-cvxni7cd 14 31 of of IN cord-280642-cvxni7cd 14 32 clinical clinical JJ cord-280642-cvxni7cd 14 33 interest interest NN cord-280642-cvxni7cd 14 34 and and CC cord-280642-cvxni7cd 14 35 prior prior JJ cord-280642-cvxni7cd 14 36 findings finding NNS cord-280642-cvxni7cd 14 37 . . . cord-280642-cvxni7cd 15 1 Results result NNS cord-280642-cvxni7cd 16 1 There there EX cord-280642-cvxni7cd 16 2 were be VBD cord-280642-cvxni7cd 16 3 5683 5683 CD cord-280642-cvxni7cd 16 4 deaths death NNS cord-280642-cvxni7cd 16 5 attributed attribute VBN cord-280642-cvxni7cd 16 6 to to IN cord-280642-cvxni7cd 16 7 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 16 8 . . . cord-280642-cvxni7cd 17 1 In in IN cord-280642-cvxni7cd 17 2 summary summary NN cord-280642-cvxni7cd 17 3 after after IN cord-280642-cvxni7cd 17 4 full full JJ cord-280642-cvxni7cd 17 5 adjustment adjustment NN cord-280642-cvxni7cd 17 6 , , , cord-280642-cvxni7cd 17 7 death death NN cord-280642-cvxni7cd 17 8 from from IN cord-280642-cvxni7cd 17 9 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 17 10 was be VBD cord-280642-cvxni7cd 17 11 strongly strongly RB cord-280642-cvxni7cd 17 12 associated associate VBN cord-280642-cvxni7cd 17 13 with with IN cord-280642-cvxni7cd 17 14 : : : cord-280642-cvxni7cd 17 15 being be VBG cord-280642-cvxni7cd 17 16 male male JJ cord-280642-cvxni7cd 17 17 ( ( -LRB- cord-280642-cvxni7cd 17 18 hazard hazard NN cord-280642-cvxni7cd 17 19 ratio ratio NN cord-280642-cvxni7cd 17 20 1.99 1.99 CD cord-280642-cvxni7cd 17 21 , , , cord-280642-cvxni7cd 17 22 95%CI 95%ci CD cord-280642-cvxni7cd 17 23 1.88 1.88 CD cord-280642-cvxni7cd 17 24 - - SYM cord-280642-cvxni7cd 17 25 2.10 2.10 CD cord-280642-cvxni7cd 17 26 ) ) -RRB- cord-280642-cvxni7cd 17 27 ; ; : cord-280642-cvxni7cd 17 28 older old JJR cord-280642-cvxni7cd 17 29 age age NN cord-280642-cvxni7cd 17 30 and and CC cord-280642-cvxni7cd 17 31 deprivation deprivation NN cord-280642-cvxni7cd 17 32 ( ( -LRB- cord-280642-cvxni7cd 17 33 both both DT cord-280642-cvxni7cd 17 34 with with IN cord-280642-cvxni7cd 17 35 a a DT cord-280642-cvxni7cd 17 36 strong strong JJ cord-280642-cvxni7cd 17 37 gradient gradient NN cord-280642-cvxni7cd 17 38 ) ) -RRB- cord-280642-cvxni7cd 17 39 ; ; , cord-280642-cvxni7cd 17 40 uncontrolled uncontrolled JJ cord-280642-cvxni7cd 17 41 diabetes diabetes NN cord-280642-cvxni7cd 17 42 ( ( -LRB- cord-280642-cvxni7cd 17 43 HR hr NN cord-280642-cvxni7cd 17 44 2.36 2.36 CD cord-280642-cvxni7cd 17 45 95 95 CD cord-280642-cvxni7cd 17 46 % % NN cord-280642-cvxni7cd 17 47 CI CI NNP cord-280642-cvxni7cd 17 48 2.18 2.18 CD cord-280642-cvxni7cd 17 49 - - HYPH cord-280642-cvxni7cd 17 50 2.56 2.56 CD cord-280642-cvxni7cd 17 51 ) ) -RRB- cord-280642-cvxni7cd 17 52 ; ; : cord-280642-cvxni7cd 17 53 severe severe JJ cord-280642-cvxni7cd 17 54 asthma asthma NN cord-280642-cvxni7cd 17 55 ( ( -LRB- cord-280642-cvxni7cd 17 56 HR HR NNP cord-280642-cvxni7cd 17 57 1.25 1.25 CD cord-280642-cvxni7cd 17 58 CI CI NNP cord-280642-cvxni7cd 17 59 1.08 1.08 CD cord-280642-cvxni7cd 17 60 - - SYM cord-280642-cvxni7cd 17 61 1.44 1.44 CD cord-280642-cvxni7cd 17 62 ) ) -RRB- cord-280642-cvxni7cd 17 63 ; ; : cord-280642-cvxni7cd 17 64 and and CC cord-280642-cvxni7cd 17 65 various various JJ cord-280642-cvxni7cd 17 66 other other JJ cord-280642-cvxni7cd 17 67 prior prior JJ cord-280642-cvxni7cd 17 68 medical medical JJ cord-280642-cvxni7cd 17 69 conditions condition NNS cord-280642-cvxni7cd 17 70 . . . cord-280642-cvxni7cd 18 1 Compared compare VBN cord-280642-cvxni7cd 18 2 to to IN cord-280642-cvxni7cd 18 3 people people NNS cord-280642-cvxni7cd 18 4 with with IN cord-280642-cvxni7cd 18 5 ethnicity ethnicity NN cord-280642-cvxni7cd 18 6 recorded record VBN cord-280642-cvxni7cd 18 7 as as IN cord-280642-cvxni7cd 18 8 white white JJ cord-280642-cvxni7cd 18 9 , , , cord-280642-cvxni7cd 18 10 black black JJ cord-280642-cvxni7cd 18 11 people people NNS cord-280642-cvxni7cd 18 12 were be VBD cord-280642-cvxni7cd 18 13 at at IN cord-280642-cvxni7cd 18 14 higher high JJR cord-280642-cvxni7cd 18 15 risk risk NN cord-280642-cvxni7cd 18 16 of of IN cord-280642-cvxni7cd 18 17 death death NN cord-280642-cvxni7cd 18 18 , , , cord-280642-cvxni7cd 18 19 with with IN cord-280642-cvxni7cd 18 20 only only JJ cord-280642-cvxni7cd 18 21 partial partial JJ cord-280642-cvxni7cd 18 22 attenuation attenuation NN cord-280642-cvxni7cd 18 23 in in IN cord-280642-cvxni7cd 18 24 hazard hazard NN cord-280642-cvxni7cd 18 25 ratios ratio NNS cord-280642-cvxni7cd 18 26 from from IN cord-280642-cvxni7cd 18 27 the the DT cord-280642-cvxni7cd 18 28 fully fully RB cord-280642-cvxni7cd 18 29 adjusted adjust VBN cord-280642-cvxni7cd 18 30 model model NN cord-280642-cvxni7cd 18 31 ( ( -LRB- cord-280642-cvxni7cd 18 32 age age NN cord-280642-cvxni7cd 18 33 - - HYPH cord-280642-cvxni7cd 18 34 sex sex NN cord-280642-cvxni7cd 18 35 adjusted adjust VBN cord-280642-cvxni7cd 18 36 HR HR NNP cord-280642-cvxni7cd 18 37 2.17 2.17 CD cord-280642-cvxni7cd 18 38 95 95 CD cord-280642-cvxni7cd 18 39 % % NN cord-280642-cvxni7cd 18 40 CI CI NNP cord-280642-cvxni7cd 18 41 1.84 1.84 CD cord-280642-cvxni7cd 18 42 - - HYPH cord-280642-cvxni7cd 18 43 2.57 2.57 CD cord-280642-cvxni7cd 18 44 ; ; : cord-280642-cvxni7cd 18 45 fully fully RB cord-280642-cvxni7cd 18 46 adjusted adjust VBN cord-280642-cvxni7cd 18 47 HR HR NNP cord-280642-cvxni7cd 18 48 1.71 1.71 CD cord-280642-cvxni7cd 18 49 95 95 CD cord-280642-cvxni7cd 18 50 % % NN cord-280642-cvxni7cd 18 51 CI CI NNP cord-280642-cvxni7cd 18 52 1.44 1.44 CD cord-280642-cvxni7cd 18 53 - - HYPH cord-280642-cvxni7cd 18 54 2.02 2.02 CD cord-280642-cvxni7cd 18 55 ) ) -RRB- cord-280642-cvxni7cd 18 56 ; ; : cord-280642-cvxni7cd 18 57 with with IN cord-280642-cvxni7cd 18 58 similar similar JJ cord-280642-cvxni7cd 18 59 findings finding NNS cord-280642-cvxni7cd 18 60 for for IN cord-280642-cvxni7cd 18 61 Asian asian JJ cord-280642-cvxni7cd 18 62 people people NNS cord-280642-cvxni7cd 18 63 ( ( -LRB- cord-280642-cvxni7cd 18 64 age age NN cord-280642-cvxni7cd 18 65 - - HYPH cord-280642-cvxni7cd 18 66 sex sex NN cord-280642-cvxni7cd 18 67 adjusted adjust VBN cord-280642-cvxni7cd 18 68 HR HR NNP cord-280642-cvxni7cd 18 69 1.95 1.95 CD cord-280642-cvxni7cd 18 70 95 95 CD cord-280642-cvxni7cd 18 71 % % NN cord-280642-cvxni7cd 18 72 CI CI NNP cord-280642-cvxni7cd 18 73 1.73 1.73 CD cord-280642-cvxni7cd 18 74 - - HYPH cord-280642-cvxni7cd 18 75 2.18 2.18 CD cord-280642-cvxni7cd 18 76 ; ; : cord-280642-cvxni7cd 18 77 fully fully RB cord-280642-cvxni7cd 18 78 adjusted adjust VBN cord-280642-cvxni7cd 18 79 HR HR NNP cord-280642-cvxni7cd 18 80 1.62 1.62 CD cord-280642-cvxni7cd 18 81 95 95 CD cord-280642-cvxni7cd 18 82 % % NN cord-280642-cvxni7cd 18 83 CI CI NNP cord-280642-cvxni7cd 18 84 1.43 1.43 CD cord-280642-cvxni7cd 18 85 - - HYPH cord-280642-cvxni7cd 18 86 1.82 1.82 CD cord-280642-cvxni7cd 18 87 ) ) -RRB- cord-280642-cvxni7cd 18 88 . . . cord-280642-cvxni7cd 19 1 Conclusions conclusion NNS cord-280642-cvxni7cd 20 1 We -PRON- PRP cord-280642-cvxni7cd 20 2 have have VBP cord-280642-cvxni7cd 20 3 quantified quantify VBN cord-280642-cvxni7cd 20 4 a a DT cord-280642-cvxni7cd 20 5 range range NN cord-280642-cvxni7cd 20 6 of of IN cord-280642-cvxni7cd 20 7 clinical clinical JJ cord-280642-cvxni7cd 20 8 risk risk NN cord-280642-cvxni7cd 20 9 factors factor NNS cord-280642-cvxni7cd 20 10 for for IN cord-280642-cvxni7cd 20 11 death death NN cord-280642-cvxni7cd 20 12 from from IN cord-280642-cvxni7cd 20 13 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 20 14 , , , cord-280642-cvxni7cd 20 15 some some DT cord-280642-cvxni7cd 20 16 of of IN cord-280642-cvxni7cd 20 17 which which WDT cord-280642-cvxni7cd 20 18 were be VBD cord-280642-cvxni7cd 20 19 not not RB cord-280642-cvxni7cd 20 20 previously previously RB cord-280642-cvxni7cd 20 21 well well RB cord-280642-cvxni7cd 20 22 characterised characterised JJ cord-280642-cvxni7cd 20 23 , , , cord-280642-cvxni7cd 20 24 in in IN cord-280642-cvxni7cd 20 25 the the DT cord-280642-cvxni7cd 20 26 largest large JJS cord-280642-cvxni7cd 20 27 cohort cohort NN cord-280642-cvxni7cd 20 28 study study NN cord-280642-cvxni7cd 20 29 conducted conduct VBN cord-280642-cvxni7cd 20 30 by by IN cord-280642-cvxni7cd 20 31 any any DT cord-280642-cvxni7cd 20 32 country country NN cord-280642-cvxni7cd 20 33 to to IN cord-280642-cvxni7cd 20 34 date date NN cord-280642-cvxni7cd 20 35 . . . cord-280642-cvxni7cd 21 1 People People NNS cord-280642-cvxni7cd 21 2 from from IN cord-280642-cvxni7cd 21 3 Asian asian JJ cord-280642-cvxni7cd 21 4 and and CC cord-280642-cvxni7cd 21 5 black black JJ cord-280642-cvxni7cd 21 6 groups group NNS cord-280642-cvxni7cd 21 7 are be VBP cord-280642-cvxni7cd 21 8 at at IN cord-280642-cvxni7cd 21 9 markedly markedly RB cord-280642-cvxni7cd 21 10 increased increase VBN cord-280642-cvxni7cd 21 11 risk risk NN cord-280642-cvxni7cd 21 12 of of IN cord-280642-cvxni7cd 21 13 in in IN cord-280642-cvxni7cd 21 14 - - HYPH cord-280642-cvxni7cd 21 15 hospital hospital NN cord-280642-cvxni7cd 21 16 death death NN cord-280642-cvxni7cd 21 17 from from IN cord-280642-cvxni7cd 21 18 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 21 19 , , , cord-280642-cvxni7cd 21 20 and and CC cord-280642-cvxni7cd 21 21 contrary contrary JJ cord-280642-cvxni7cd 21 22 to to IN cord-280642-cvxni7cd 21 23 some some DT cord-280642-cvxni7cd 21 24 prior prior JJ cord-280642-cvxni7cd 21 25 speculation speculation NN cord-280642-cvxni7cd 22 1 this this DT cord-280642-cvxni7cd 22 2 is be VBZ cord-280642-cvxni7cd 22 3 only only RB cord-280642-cvxni7cd 22 4 partially partially RB cord-280642-cvxni7cd 22 5 attributable attributable JJ cord-280642-cvxni7cd 22 6 to to IN cord-280642-cvxni7cd 22 7 pre pre VB cord-280642-cvxni7cd 22 8 - - JJ cord-280642-cvxni7cd 22 9 existing existing JJ cord-280642-cvxni7cd 22 10 clinical clinical JJ cord-280642-cvxni7cd 22 11 risk risk NN cord-280642-cvxni7cd 22 12 factors factor NNS cord-280642-cvxni7cd 22 13 or or CC cord-280642-cvxni7cd 22 14 deprivation deprivation NN cord-280642-cvxni7cd 22 15 ; ; : cord-280642-cvxni7cd 22 16 further further JJ cord-280642-cvxni7cd 22 17 research research NN cord-280642-cvxni7cd 22 18 into into IN cord-280642-cvxni7cd 22 19 the the DT cord-280642-cvxni7cd 22 20 drivers driver NNS cord-280642-cvxni7cd 22 21 of of IN cord-280642-cvxni7cd 22 22 this this DT cord-280642-cvxni7cd 22 23 association association NN cord-280642-cvxni7cd 22 24 is be VBZ cord-280642-cvxni7cd 22 25 therefore therefore RB cord-280642-cvxni7cd 22 26 urgently urgently RB cord-280642-cvxni7cd 22 27 required require VBN cord-280642-cvxni7cd 22 28 . . . cord-280642-cvxni7cd 23 1 Deprivation deprivation NN cord-280642-cvxni7cd 23 2 is be VBZ cord-280642-cvxni7cd 23 3 also also RB cord-280642-cvxni7cd 23 4 a a DT cord-280642-cvxni7cd 23 5 major major JJ cord-280642-cvxni7cd 23 6 risk risk NN cord-280642-cvxni7cd 23 7 factor factor NN cord-280642-cvxni7cd 23 8 with with IN cord-280642-cvxni7cd 23 9 , , , cord-280642-cvxni7cd 23 10 again again RB cord-280642-cvxni7cd 23 11 , , , cord-280642-cvxni7cd 23 12 little little JJ cord-280642-cvxni7cd 23 13 of of IN cord-280642-cvxni7cd 23 14 the the DT cord-280642-cvxni7cd 23 15 excess excess JJ cord-280642-cvxni7cd 23 16 risk risk NN cord-280642-cvxni7cd 23 17 explained explain VBN cord-280642-cvxni7cd 23 18 by by IN cord-280642-cvxni7cd 23 19 co co NN cord-280642-cvxni7cd 23 20 - - NN cord-280642-cvxni7cd 23 21 morbidity morbidity JJ cord-280642-cvxni7cd 23 22 or or CC cord-280642-cvxni7cd 23 23 other other JJ cord-280642-cvxni7cd 23 24 risk risk NN cord-280642-cvxni7cd 23 25 factors factor NNS cord-280642-cvxni7cd 23 26 . . . cord-280642-cvxni7cd 24 1 The the DT cord-280642-cvxni7cd 24 2 findings finding NNS cord-280642-cvxni7cd 24 3 for for IN cord-280642-cvxni7cd 24 4 clinical clinical JJ cord-280642-cvxni7cd 24 5 risk risk NN cord-280642-cvxni7cd 24 6 factors factor NNS cord-280642-cvxni7cd 24 7 are be VBP cord-280642-cvxni7cd 24 8 concordant concordant JJ cord-280642-cvxni7cd 24 9 with with IN cord-280642-cvxni7cd 24 10 policies policy NNS cord-280642-cvxni7cd 24 11 in in IN cord-280642-cvxni7cd 24 12 the the DT cord-280642-cvxni7cd 24 13 UK UK NNP cord-280642-cvxni7cd 24 14 for for IN cord-280642-cvxni7cd 24 15 protecting protect VBG cord-280642-cvxni7cd 24 16 those those DT cord-280642-cvxni7cd 24 17 at at IN cord-280642-cvxni7cd 24 18 highest high JJS cord-280642-cvxni7cd 24 19 risk risk NN cord-280642-cvxni7cd 24 20 . . . cord-280642-cvxni7cd 25 1 Our -PRON- PRP$ cord-280642-cvxni7cd 25 2 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 25 3 platform platform NN cord-280642-cvxni7cd 25 4 is be VBZ cord-280642-cvxni7cd 25 5 rapidly rapidly RB cord-280642-cvxni7cd 25 6 adding add VBG cord-280642-cvxni7cd 25 7 further further JJ cord-280642-cvxni7cd 25 8 NHS NHS NNP cord-280642-cvxni7cd 25 9 patients patient NNS cord-280642-cvxni7cd 25 10 ' ' POS cord-280642-cvxni7cd 25 11 records record NNS cord-280642-cvxni7cd 25 12 ; ; : cord-280642-cvxni7cd 25 13 we -PRON- PRP cord-280642-cvxni7cd 25 14 will will MD cord-280642-cvxni7cd 25 15 update update VB cord-280642-cvxni7cd 25 16 and and CC cord-280642-cvxni7cd 25 17 extend extend VB cord-280642-cvxni7cd 25 18 these these DT cord-280642-cvxni7cd 25 19 results result NNS cord-280642-cvxni7cd 25 20 regularly regularly RB cord-280642-cvxni7cd 25 21 . . . cord-280642-cvxni7cd 26 1 Keywords Keywords NNP cord-280642-cvxni7cd 26 2 COVID-19 covid-19 VBP cord-280642-cvxni7cd 26 3 , , , cord-280642-cvxni7cd 26 4 risk risk NN cord-280642-cvxni7cd 26 5 factors factor NNS cord-280642-cvxni7cd 26 6 , , , cord-280642-cvxni7cd 26 7 ethnicity ethnicity NN cord-280642-cvxni7cd 26 8 , , , cord-280642-cvxni7cd 26 9 deprivation deprivation NN cord-280642-cvxni7cd 26 10 , , , cord-280642-cvxni7cd 26 11 death death NN cord-280642-cvxni7cd 26 12 , , , cord-280642-cvxni7cd 26 13 informatics informatics NN cord-280642-cvxni7cd 26 14 . . . cord-280642-cvxni7cd 27 1 Results result NNS cord-280642-cvxni7cd 27 2 : : : cord-280642-cvxni7cd 28 1 There there EX cord-280642-cvxni7cd 28 2 were be VBD cord-280642-cvxni7cd 28 3 5683 5683 CD cord-280642-cvxni7cd 28 4 deaths death NNS cord-280642-cvxni7cd 28 5 attributed attribute VBN cord-280642-cvxni7cd 28 6 to to IN cord-280642-cvxni7cd 28 7 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 28 8 . . . cord-280642-cvxni7cd 29 1 In in IN cord-280642-cvxni7cd 29 2 summary summary NN cord-280642-cvxni7cd 29 3 after after IN cord-280642-cvxni7cd 29 4 full full JJ cord-280642-cvxni7cd 29 5 adjustment adjustment NN cord-280642-cvxni7cd 29 6 , , , cord-280642-cvxni7cd 29 7 death death NN cord-280642-cvxni7cd 29 8 from from IN cord-280642-cvxni7cd 29 9 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 29 10 was be VBD cord-280642-cvxni7cd 29 11 strongly strongly RB cord-280642-cvxni7cd 29 12 associated associate VBN cord-280642-cvxni7cd 29 13 with with IN cord-280642-cvxni7cd 29 14 : : : cord-280642-cvxni7cd 29 15 being be VBG cord-280642-cvxni7cd 29 16 male male JJ cord-280642-cvxni7cd 29 17 ( ( -LRB- cord-280642-cvxni7cd 29 18 hazard hazard NN cord-280642-cvxni7cd 29 19 ratio ratio NN cord-280642-cvxni7cd 29 20 1.99 1.99 CD cord-280642-cvxni7cd 29 21 , , , cord-280642-cvxni7cd 29 22 95%CI 95%ci CD cord-280642-cvxni7cd 29 23 1.88 1.88 CD cord-280642-cvxni7cd 29 24 - - SYM cord-280642-cvxni7cd 29 25 2.10 2.10 CD cord-280642-cvxni7cd 29 26 ) ) -RRB- cord-280642-cvxni7cd 29 27 ; ; : cord-280642-cvxni7cd 29 28 older old JJR cord-280642-cvxni7cd 29 29 age age NN cord-280642-cvxni7cd 29 30 and and CC cord-280642-cvxni7cd 29 31 deprivation deprivation NN cord-280642-cvxni7cd 29 32 ( ( -LRB- cord-280642-cvxni7cd 29 33 both both DT cord-280642-cvxni7cd 29 34 with with IN cord-280642-cvxni7cd 29 35 a a DT cord-280642-cvxni7cd 29 36 strong strong JJ cord-280642-cvxni7cd 29 37 gradient gradient NN cord-280642-cvxni7cd 29 38 ) ) -RRB- cord-280642-cvxni7cd 29 39 ; ; , cord-280642-cvxni7cd 29 40 uncontrolled uncontrolled JJ cord-280642-cvxni7cd 29 41 diabetes diabetes NN cord-280642-cvxni7cd 29 42 ( ( -LRB- cord-280642-cvxni7cd 29 43 HR hr NN cord-280642-cvxni7cd 29 44 2.36 2.36 CD cord-280642-cvxni7cd 29 45 95 95 CD cord-280642-cvxni7cd 29 46 % % NN cord-280642-cvxni7cd 29 47 CI CI NNP cord-280642-cvxni7cd 29 48 2.18 2.18 CD cord-280642-cvxni7cd 29 49 - - HYPH cord-280642-cvxni7cd 29 50 2.56 2.56 CD cord-280642-cvxni7cd 29 51 ) ) -RRB- cord-280642-cvxni7cd 29 52 ; ; : cord-280642-cvxni7cd 29 53 severe severe JJ cord-280642-cvxni7cd 29 54 asthma asthma NN cord-280642-cvxni7cd 29 55 ( ( -LRB- cord-280642-cvxni7cd 29 56 HR HR NNP cord-280642-cvxni7cd 29 57 1.25 1.25 CD cord-280642-cvxni7cd 29 58 CI CI NNP cord-280642-cvxni7cd 29 59 1.08 1.08 CD cord-280642-cvxni7cd 29 60 - - SYM cord-280642-cvxni7cd 29 61 1.44 1.44 CD cord-280642-cvxni7cd 29 62 ) ) -RRB- cord-280642-cvxni7cd 29 63 ; ; : cord-280642-cvxni7cd 29 64 and and CC cord-280642-cvxni7cd 29 65 various various JJ cord-280642-cvxni7cd 29 66 other other JJ cord-280642-cvxni7cd 29 67 prior prior JJ cord-280642-cvxni7cd 29 68 medical medical JJ cord-280642-cvxni7cd 29 69 conditions condition NNS cord-280642-cvxni7cd 29 70 . . . cord-280642-cvxni7cd 30 1 Compared compare VBN cord-280642-cvxni7cd 30 2 to to IN cord-280642-cvxni7cd 30 3 people people NNS cord-280642-cvxni7cd 30 4 with with IN cord-280642-cvxni7cd 30 5 ethnicity ethnicity NN cord-280642-cvxni7cd 30 6 recorded record VBN cord-280642-cvxni7cd 30 7 as as IN cord-280642-cvxni7cd 30 8 white white JJ cord-280642-cvxni7cd 30 9 , , , cord-280642-cvxni7cd 30 10 black black JJ cord-280642-cvxni7cd 30 11 people people NNS cord-280642-cvxni7cd 30 12 were be VBD cord-280642-cvxni7cd 30 13 at at IN cord-280642-cvxni7cd 30 14 higher high JJR cord-280642-cvxni7cd 30 15 risk risk NN cord-280642-cvxni7cd 30 16 of of IN cord-280642-cvxni7cd 30 17 death death NN cord-280642-cvxni7cd 30 18 , , , cord-280642-cvxni7cd 30 19 with with IN cord-280642-cvxni7cd 30 20 only only JJ cord-280642-cvxni7cd 30 21 partial partial JJ cord-280642-cvxni7cd 30 22 attenuation attenuation NN cord-280642-cvxni7cd 30 23 in in IN cord-280642-cvxni7cd 30 24 hazard hazard NN cord-280642-cvxni7cd 30 25 ratios ratio NNS cord-280642-cvxni7cd 30 26 from from IN cord-280642-cvxni7cd 30 27 the the DT cord-280642-cvxni7cd 30 28 fully fully RB cord-280642-cvxni7cd 30 29 adjusted adjust VBN cord-280642-cvxni7cd 30 30 model model NN cord-280642-cvxni7cd 30 31 ( ( -LRB- cord-280642-cvxni7cd 30 32 age age NN cord-280642-cvxni7cd 30 33 - - HYPH cord-280642-cvxni7cd 30 34 sex sex NN cord-280642-cvxni7cd 30 35 adjusted adjust VBN cord-280642-cvxni7cd 30 36 HR HR NNP cord-280642-cvxni7cd 30 37 2.17 2.17 CD cord-280642-cvxni7cd 30 38 95 95 CD cord-280642-cvxni7cd 30 39 % % NN cord-280642-cvxni7cd 30 40 CI CI NNP cord-280642-cvxni7cd 30 41 1.84 1.84 CD cord-280642-cvxni7cd 30 42 - - HYPH cord-280642-cvxni7cd 30 43 2.57 2.57 CD cord-280642-cvxni7cd 30 44 ; ; : cord-280642-cvxni7cd 30 45 fully fully RB cord-280642-cvxni7cd 30 46 adjusted adjust VBN cord-280642-cvxni7cd 30 47 HR HR NNP cord-280642-cvxni7cd 30 48 1.71 1.71 CD cord-280642-cvxni7cd 30 49 95 95 CD cord-280642-cvxni7cd 30 50 % % NN cord-280642-cvxni7cd 30 51 CI CI NNP cord-280642-cvxni7cd 30 52 1.44 1.44 CD cord-280642-cvxni7cd 30 53 - - HYPH cord-280642-cvxni7cd 30 54 2.02 2.02 CD cord-280642-cvxni7cd 30 55 ) ) -RRB- cord-280642-cvxni7cd 30 56 ; ; : cord-280642-cvxni7cd 30 57 with with IN cord-280642-cvxni7cd 30 58 similar similar JJ cord-280642-cvxni7cd 30 59 findings finding NNS cord-280642-cvxni7cd 30 60 for for IN cord-280642-cvxni7cd 30 61 Asian asian JJ cord-280642-cvxni7cd 30 62 people people NNS cord-280642-cvxni7cd 30 63 ( ( -LRB- cord-280642-cvxni7cd 30 64 age age NN cord-280642-cvxni7cd 30 65 - - HYPH cord-280642-cvxni7cd 30 66 sex sex NN cord-280642-cvxni7cd 30 67 adjusted adjust VBN cord-280642-cvxni7cd 30 68 HR HR NNP cord-280642-cvxni7cd 30 69 1.95 1.95 CD cord-280642-cvxni7cd 30 70 95 95 CD cord-280642-cvxni7cd 30 71 % % NN cord-280642-cvxni7cd 30 72 CI CI NNP cord-280642-cvxni7cd 30 73 1.73 1.73 CD cord-280642-cvxni7cd 30 74 - - HYPH cord-280642-cvxni7cd 30 75 2.18 2.18 CD cord-280642-cvxni7cd 30 76 ; ; : cord-280642-cvxni7cd 30 77 fully fully RB cord-280642-cvxni7cd 30 78 adjusted adjust VBN cord-280642-cvxni7cd 30 79 HR HR NNP cord-280642-cvxni7cd 30 80 1.62 1.62 CD cord-280642-cvxni7cd 30 81 95 95 CD cord-280642-cvxni7cd 30 82 % % NN cord-280642-cvxni7cd 30 83 CI CI NNP cord-280642-cvxni7cd 30 84 1.43 1.43 CD cord-280642-cvxni7cd 30 85 - - HYPH cord-280642-cvxni7cd 30 86 1.82 1.82 CD cord-280642-cvxni7cd 30 87 ) ) -RRB- cord-280642-cvxni7cd 30 88 . . . cord-280642-cvxni7cd 31 1 We -PRON- PRP cord-280642-cvxni7cd 31 2 have have VBP cord-280642-cvxni7cd 31 3 quantified quantify VBN cord-280642-cvxni7cd 31 4 a a DT cord-280642-cvxni7cd 31 5 range range NN cord-280642-cvxni7cd 31 6 of of IN cord-280642-cvxni7cd 31 7 clinical clinical JJ cord-280642-cvxni7cd 31 8 risk risk NN cord-280642-cvxni7cd 31 9 factors factor NNS cord-280642-cvxni7cd 31 10 for for IN cord-280642-cvxni7cd 31 11 death death NN cord-280642-cvxni7cd 31 12 from from IN cord-280642-cvxni7cd 31 13 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 31 14 , , , cord-280642-cvxni7cd 31 15 some some DT cord-280642-cvxni7cd 31 16 of of IN cord-280642-cvxni7cd 31 17 which which WDT cord-280642-cvxni7cd 31 18 were be VBD cord-280642-cvxni7cd 31 19 not not RB cord-280642-cvxni7cd 31 20 previously previously RB cord-280642-cvxni7cd 31 21 well well RB cord-280642-cvxni7cd 31 22 characterised characterised JJ cord-280642-cvxni7cd 31 23 , , , cord-280642-cvxni7cd 31 24 in in IN cord-280642-cvxni7cd 31 25 the the DT cord-280642-cvxni7cd 31 26 largest large JJS cord-280642-cvxni7cd 31 27 cohort cohort NN cord-280642-cvxni7cd 31 28 study study NN cord-280642-cvxni7cd 31 29 conducted conduct VBN cord-280642-cvxni7cd 31 30 by by IN cord-280642-cvxni7cd 31 31 any any DT cord-280642-cvxni7cd 31 32 country country NN cord-280642-cvxni7cd 31 33 to to IN cord-280642-cvxni7cd 31 34 date date NN cord-280642-cvxni7cd 31 35 . . . cord-280642-cvxni7cd 32 1 People People NNS cord-280642-cvxni7cd 32 2 from from IN cord-280642-cvxni7cd 32 3 Asian asian JJ cord-280642-cvxni7cd 32 4 and and CC cord-280642-cvxni7cd 32 5 black black JJ cord-280642-cvxni7cd 32 6 groups group NNS cord-280642-cvxni7cd 32 7 are be VBP cord-280642-cvxni7cd 32 8 at at IN cord-280642-cvxni7cd 32 9 markedly markedly RB cord-280642-cvxni7cd 32 10 increased increase VBN cord-280642-cvxni7cd 32 11 risk risk NN cord-280642-cvxni7cd 32 12 of of IN cord-280642-cvxni7cd 32 13 in in IN cord-280642-cvxni7cd 32 14 - - HYPH cord-280642-cvxni7cd 32 15 hospital hospital NN cord-280642-cvxni7cd 32 16 death death NN cord-280642-cvxni7cd 32 17 from from IN cord-280642-cvxni7cd 32 18 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 32 19 , , , cord-280642-cvxni7cd 32 20 and and CC cord-280642-cvxni7cd 32 21 contrary contrary JJ cord-280642-cvxni7cd 32 22 to to IN cord-280642-cvxni7cd 32 23 some some DT cord-280642-cvxni7cd 32 24 prior prior JJ cord-280642-cvxni7cd 32 25 speculation speculation NN cord-280642-cvxni7cd 33 1 this this DT cord-280642-cvxni7cd 33 2 is be VBZ cord-280642-cvxni7cd 33 3 only only RB cord-280642-cvxni7cd 33 4 partially partially RB cord-280642-cvxni7cd 33 5 attributable attributable JJ cord-280642-cvxni7cd 33 6 to to IN cord-280642-cvxni7cd 33 7 pre pre VB cord-280642-cvxni7cd 33 8 - - JJ cord-280642-cvxni7cd 33 9 existing existing JJ cord-280642-cvxni7cd 33 10 clinical clinical JJ cord-280642-cvxni7cd 33 11 risk risk NN cord-280642-cvxni7cd 33 12 factors factor NNS cord-280642-cvxni7cd 33 13 or or CC cord-280642-cvxni7cd 33 14 deprivation deprivation NN cord-280642-cvxni7cd 33 15 ; ; : cord-280642-cvxni7cd 33 16 further further JJ cord-280642-cvxni7cd 33 17 research research NN cord-280642-cvxni7cd 33 18 into into IN cord-280642-cvxni7cd 33 19 the the DT cord-280642-cvxni7cd 33 20 drivers driver NNS cord-280642-cvxni7cd 33 21 of of IN cord-280642-cvxni7cd 33 22 this this DT cord-280642-cvxni7cd 33 23 association association NN cord-280642-cvxni7cd 33 24 is be VBZ cord-280642-cvxni7cd 33 25 therefore therefore RB cord-280642-cvxni7cd 33 26 urgently urgently RB cord-280642-cvxni7cd 33 27 required require VBN cord-280642-cvxni7cd 33 28 . . . cord-280642-cvxni7cd 34 1 Deprivation deprivation NN cord-280642-cvxni7cd 34 2 is be VBZ cord-280642-cvxni7cd 34 3 also also RB cord-280642-cvxni7cd 34 4 a a DT cord-280642-cvxni7cd 34 5 major major JJ cord-280642-cvxni7cd 34 6 risk risk NN cord-280642-cvxni7cd 34 7 factor factor NN cord-280642-cvxni7cd 34 8 with with IN cord-280642-cvxni7cd 34 9 , , , cord-280642-cvxni7cd 34 10 again again RB cord-280642-cvxni7cd 34 11 , , , cord-280642-cvxni7cd 34 12 little little JJ cord-280642-cvxni7cd 34 13 of of IN cord-280642-cvxni7cd 34 14 the the DT cord-280642-cvxni7cd 34 15 excess excess JJ cord-280642-cvxni7cd 34 16 risk risk NN cord-280642-cvxni7cd 34 17 explained explain VBN cord-280642-cvxni7cd 34 18 by by IN cord-280642-cvxni7cd 34 19 co co NN cord-280642-cvxni7cd 34 20 - - NN cord-280642-cvxni7cd 34 21 morbidity morbidity JJ cord-280642-cvxni7cd 34 22 or or CC cord-280642-cvxni7cd 34 23 other other JJ cord-280642-cvxni7cd 34 24 risk risk NN cord-280642-cvxni7cd 34 25 factors factor NNS cord-280642-cvxni7cd 34 26 . . . cord-280642-cvxni7cd 35 1 The the DT cord-280642-cvxni7cd 35 2 findings finding NNS cord-280642-cvxni7cd 35 3 for for IN cord-280642-cvxni7cd 35 4 clinical clinical JJ cord-280642-cvxni7cd 35 5 risk risk NN cord-280642-cvxni7cd 35 6 factors factor NNS cord-280642-cvxni7cd 35 7 are be VBP cord-280642-cvxni7cd 35 8 concordant concordant JJ cord-280642-cvxni7cd 35 9 with with IN cord-280642-cvxni7cd 35 10 policies policy NNS cord-280642-cvxni7cd 35 11 in in IN cord-280642-cvxni7cd 35 12 the the DT cord-280642-cvxni7cd 35 13 UK UK NNP cord-280642-cvxni7cd 35 14 for for IN cord-280642-cvxni7cd 35 15 protecting protect VBG cord-280642-cvxni7cd 35 16 those those DT cord-280642-cvxni7cd 35 17 at at IN cord-280642-cvxni7cd 35 18 highest high JJS cord-280642-cvxni7cd 35 19 risk risk NN cord-280642-cvxni7cd 35 20 . . . cord-280642-cvxni7cd 36 1 Our -PRON- PRP$ cord-280642-cvxni7cd 36 2 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 36 3 platform platform NN cord-280642-cvxni7cd 36 4 is be VBZ cord-280642-cvxni7cd 36 5 rapidly rapidly RB cord-280642-cvxni7cd 36 6 adding add VBG cord-280642-cvxni7cd 36 7 further further JJ cord-280642-cvxni7cd 36 8 NHS NHS NNP cord-280642-cvxni7cd 36 9 patients patient NNS cord-280642-cvxni7cd 36 10 ' ' POS cord-280642-cvxni7cd 36 11 records record NNS cord-280642-cvxni7cd 36 12 ; ; : cord-280642-cvxni7cd 36 13 we -PRON- PRP cord-280642-cvxni7cd 36 14 will will MD cord-280642-cvxni7cd 36 15 update update VB cord-280642-cvxni7cd 36 16 and and CC cord-280642-cvxni7cd 36 17 extend extend VB cord-280642-cvxni7cd 36 18 these these DT cord-280642-cvxni7cd 36 19 results result NNS cord-280642-cvxni7cd 36 20 regularly regularly RB cord-280642-cvxni7cd 36 21 . . . cord-280642-cvxni7cd 37 1 On on IN cord-280642-cvxni7cd 37 2 March March NNP cord-280642-cvxni7cd 37 3 11th 11th NN cord-280642-cvxni7cd 37 4 2020 2020 CD cord-280642-cvxni7cd 37 5 , , , cord-280642-cvxni7cd 37 6 the the DT cord-280642-cvxni7cd 37 7 World World NNP cord-280642-cvxni7cd 37 8 Health Health NNP cord-280642-cvxni7cd 37 9 Organisation Organisation NNP cord-280642-cvxni7cd 37 10 characterised characterise VBD cord-280642-cvxni7cd 37 11 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 37 12 as as IN cord-280642-cvxni7cd 37 13 a a DT cord-280642-cvxni7cd 37 14 pandemic pandemic NN cord-280642-cvxni7cd 37 15 after after IN cord-280642-cvxni7cd 37 16 118,000 118,000 CD cord-280642-cvxni7cd 37 17 cases case NNS cord-280642-cvxni7cd 37 18 and and CC cord-280642-cvxni7cd 37 19 4,291 4,291 CD cord-280642-cvxni7cd 37 20 deaths death NNS cord-280642-cvxni7cd 37 21 were be VBD cord-280642-cvxni7cd 37 22 reported report VBN cord-280642-cvxni7cd 37 23 in in IN cord-280642-cvxni7cd 37 24 114 114 CD cord-280642-cvxni7cd 37 25 countries country NNS cord-280642-cvxni7cd 37 26 . . . cord-280642-cvxni7cd 38 1 1 1 LS cord-280642-cvxni7cd 39 1 As as IN cord-280642-cvxni7cd 39 2 of of IN cord-280642-cvxni7cd 39 3 30 30 CD cord-280642-cvxni7cd 39 4 April April NNP cord-280642-cvxni7cd 39 5 , , , cord-280642-cvxni7cd 39 6 cases case NNS cord-280642-cvxni7cd 39 7 are be VBP cord-280642-cvxni7cd 39 8 over over IN cord-280642-cvxni7cd 39 9 3 3 CD cord-280642-cvxni7cd 39 10 million million CD cord-280642-cvxni7cd 39 11 globally globally RB cord-280642-cvxni7cd 39 12 , , , cord-280642-cvxni7cd 39 13 with with IN cord-280642-cvxni7cd 39 14 more more JJR cord-280642-cvxni7cd 39 15 than than IN cord-280642-cvxni7cd 39 16 200,000 200,000 CD cord-280642-cvxni7cd 39 17 deaths death NNS cord-280642-cvxni7cd 39 18 attributed attribute VBN cord-280642-cvxni7cd 39 19 to to IN cord-280642-cvxni7cd 39 20 the the DT cord-280642-cvxni7cd 39 21 virus virus NN cord-280642-cvxni7cd 39 22 . . . cord-280642-cvxni7cd 40 1 2 2 LS cord-280642-cvxni7cd 41 1 In in IN cord-280642-cvxni7cd 41 2 the the DT cord-280642-cvxni7cd 41 3 UK UK NNP cord-280642-cvxni7cd 41 4 , , , cord-280642-cvxni7cd 41 5 cases case NNS cord-280642-cvxni7cd 41 6 have have VBP cord-280642-cvxni7cd 41 7 reached reach VBN cord-280642-cvxni7cd 41 8 171,253 171,253 CD cord-280642-cvxni7cd 41 9 , , , cord-280642-cvxni7cd 41 10 with with IN cord-280642-cvxni7cd 41 11 22,791 22,791 CD cord-280642-cvxni7cd 41 12 deaths death NNS cord-280642-cvxni7cd 41 13 in in IN cord-280642-cvxni7cd 41 14 hospital hospital NN cord-280642-cvxni7cd 41 15 . . . cord-280642-cvxni7cd 42 1 3 3 LS cord-280642-cvxni7cd 43 1 Age age NN cord-280642-cvxni7cd 43 2 and and CC cord-280642-cvxni7cd 43 3 gender gender NN cord-280642-cvxni7cd 43 4 are be VBP cord-280642-cvxni7cd 43 5 well well RB cord-280642-cvxni7cd 43 6 - - HYPH cord-280642-cvxni7cd 43 7 established establish VBN cord-280642-cvxni7cd 43 8 risk risk NN cord-280642-cvxni7cd 43 9 factors factor NNS cord-280642-cvxni7cd 43 10 , , , cord-280642-cvxni7cd 43 11 with with IN cord-280642-cvxni7cd 43 12 over over IN cord-280642-cvxni7cd 43 13 90 90 CD cord-280642-cvxni7cd 43 14 % % NN cord-280642-cvxni7cd 43 15 of of IN cord-280642-cvxni7cd 43 16 UK UK NNP cord-280642-cvxni7cd 43 17 deaths death NNS cord-280642-cvxni7cd 43 18 to to IN cord-280642-cvxni7cd 43 19 date date NN cord-280642-cvxni7cd 43 20 being be VBG cord-280642-cvxni7cd 43 21 in in IN cord-280642-cvxni7cd 43 22 people people NNS cord-280642-cvxni7cd 43 23 aged age VBN cord-280642-cvxni7cd 43 24 over over IN cord-280642-cvxni7cd 43 25 60 60 CD cord-280642-cvxni7cd 43 26 years year NNS cord-280642-cvxni7cd 43 27 , , , cord-280642-cvxni7cd 43 28 and and CC cord-280642-cvxni7cd 43 29 60 60 CD cord-280642-cvxni7cd 43 30 % % NN cord-280642-cvxni7cd 43 31 of of IN cord-280642-cvxni7cd 43 32 deaths death NNS cord-280642-cvxni7cd 43 33 in in IN cord-280642-cvxni7cd 43 34 men man NNS cord-280642-cvxni7cd 43 35 , , , cord-280642-cvxni7cd 43 36 4 4 CD cord-280642-cvxni7cd 43 37 consistent consistent JJ cord-280642-cvxni7cd 43 38 with with IN cord-280642-cvxni7cd 43 39 global global JJ cord-280642-cvxni7cd 43 40 patterns pattern NNS cord-280642-cvxni7cd 43 41 . . . cord-280642-cvxni7cd 44 1 Various various JJ cord-280642-cvxni7cd 44 2 pre pre JJ cord-280642-cvxni7cd 44 3 - - JJ cord-280642-cvxni7cd 44 4 existing existing JJ cord-280642-cvxni7cd 44 5 conditions condition NNS cord-280642-cvxni7cd 44 6 have have VBP cord-280642-cvxni7cd 44 7 been be VBN cord-280642-cvxni7cd 44 8 reported report VBN cord-280642-cvxni7cd 44 9 to to TO cord-280642-cvxni7cd 44 10 correlate correlate VB cord-280642-cvxni7cd 44 11 with with IN cord-280642-cvxni7cd 44 12 increased increase VBN cord-280642-cvxni7cd 44 13 risk risk NN cord-280642-cvxni7cd 44 14 of of IN cord-280642-cvxni7cd 44 15 poor poor JJ cord-280642-cvxni7cd 44 16 outcomes outcome NNS cord-280642-cvxni7cd 44 17 . . . cord-280642-cvxni7cd 45 1 In in IN cord-280642-cvxni7cd 45 2 a a DT cord-280642-cvxni7cd 45 3 re re NN cord-280642-cvxni7cd 45 4 - - NN cord-280642-cvxni7cd 45 5 analysis analysis NN cord-280642-cvxni7cd 45 6 of of IN cord-280642-cvxni7cd 45 7 a a DT cord-280642-cvxni7cd 45 8 large large JJ cord-280642-cvxni7cd 45 9 aggregated aggregated JJ cord-280642-cvxni7cd 45 10 case case NN cord-280642-cvxni7cd 45 11 series series NN cord-280642-cvxni7cd 45 12 dataset dataset NN cord-280642-cvxni7cd 45 13 from from IN cord-280642-cvxni7cd 45 14 the the DT cord-280642-cvxni7cd 45 15 Chinese chinese JJ cord-280642-cvxni7cd 45 16 center center NN cord-280642-cvxni7cd 45 17 for for IN cord-280642-cvxni7cd 45 18 disease disease NNP cord-280642-cvxni7cd 45 19 control control NN cord-280642-cvxni7cd 45 20 and and CC cord-280642-cvxni7cd 45 21 prevention prevention NN cord-280642-cvxni7cd 45 22 ( ( -LRB- cord-280642-cvxni7cd 45 23 44 44 CD cord-280642-cvxni7cd 45 24 , , , cord-280642-cvxni7cd 45 25 672 672 CD cord-280642-cvxni7cd 45 26 patients patient NNS cord-280642-cvxni7cd 45 27 , , , cord-280642-cvxni7cd 45 28 1,023 1,023 CD cord-280642-cvxni7cd 45 29 deaths death NNS cord-280642-cvxni7cd 45 30 ) ) -RRB- cord-280642-cvxni7cd 45 31 , , , cord-280642-cvxni7cd 45 32 cardiovascular cardiovascular JJ cord-280642-cvxni7cd 45 33 disease disease NN cord-280642-cvxni7cd 45 34 , , , cord-280642-cvxni7cd 45 35 hypertension hypertension NN cord-280642-cvxni7cd 45 36 , , , cord-280642-cvxni7cd 45 37 diabetes diabetes NN cord-280642-cvxni7cd 45 38 , , , cord-280642-cvxni7cd 45 39 respiratory respiratory JJ cord-280642-cvxni7cd 45 40 disease disease NN cord-280642-cvxni7cd 45 41 , , , cord-280642-cvxni7cd 45 42 and and CC cord-280642-cvxni7cd 45 43 cancers cancer NNS cord-280642-cvxni7cd 45 44 were be VBD cord-280642-cvxni7cd 45 45 all all DT cord-280642-cvxni7cd 45 46 associated associate VBN cord-280642-cvxni7cd 45 47 with with IN cord-280642-cvxni7cd 45 48 increased increase VBN cord-280642-cvxni7cd 45 49 risk risk NN cord-280642-cvxni7cd 45 50 of of IN cord-280642-cvxni7cd 45 51 death death NN cord-280642-cvxni7cd 45 52 . . . cord-280642-cvxni7cd 46 1 5 5 LS cord-280642-cvxni7cd 47 1 These these DT cord-280642-cvxni7cd 47 2 factors factor NNS cord-280642-cvxni7cd 47 3 often often RB cord-280642-cvxni7cd 47 4 correlate correlate VBP cord-280642-cvxni7cd 47 5 with with IN cord-280642-cvxni7cd 47 6 age age NN cord-280642-cvxni7cd 47 7 , , , cord-280642-cvxni7cd 47 8 but but CC cord-280642-cvxni7cd 47 9 correction correction NN cord-280642-cvxni7cd 47 10 for for IN cord-280642-cvxni7cd 47 11 age age NN cord-280642-cvxni7cd 47 12 was be VBD cord-280642-cvxni7cd 47 13 not not RB cord-280642-cvxni7cd 47 14 possible possible JJ cord-280642-cvxni7cd 47 15 in in IN cord-280642-cvxni7cd 47 16 the the DT cord-280642-cvxni7cd 47 17 available available JJ cord-280642-cvxni7cd 47 18 data datum NNS cord-280642-cvxni7cd 47 19 . . . cord-280642-cvxni7cd 48 1 More more RBR cord-280642-cvxni7cd 48 2 recently recently RB cord-280642-cvxni7cd 48 3 , , , cord-280642-cvxni7cd 48 4 a a DT cord-280642-cvxni7cd 48 5 large large JJ cord-280642-cvxni7cd 48 6 UK UK NNP cord-280642-cvxni7cd 48 7 cross cross JJ cord-280642-cvxni7cd 48 8 - - JJ cord-280642-cvxni7cd 48 9 sectional sectional JJ cord-280642-cvxni7cd 48 10 survey survey NN cord-280642-cvxni7cd 48 11 describing describe VBG cord-280642-cvxni7cd 48 12 16,749 16,749 CD cord-280642-cvxni7cd 48 13 patients patient NNS cord-280642-cvxni7cd 48 14 already already RB cord-280642-cvxni7cd 48 15 hospitalised hospitalise VBN cord-280642-cvxni7cd 48 16 with with IN cord-280642-cvxni7cd 48 17 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 48 18 showed show VBD cord-280642-cvxni7cd 48 19 higher high JJR cord-280642-cvxni7cd 48 20 risk risk NN cord-280642-cvxni7cd 48 21 of of IN cord-280642-cvxni7cd 48 22 death death NN cord-280642-cvxni7cd 48 23 for for IN cord-280642-cvxni7cd 48 24 patients patient NNS cord-280642-cvxni7cd 48 25 with with IN cord-280642-cvxni7cd 48 26 cardiac cardiac JJ cord-280642-cvxni7cd 48 27 , , , cord-280642-cvxni7cd 48 28 pulmonary pulmonary JJ cord-280642-cvxni7cd 48 29 and and CC cord-280642-cvxni7cd 48 30 kidney kidney NN cord-280642-cvxni7cd 48 31 disease disease NN cord-280642-cvxni7cd 48 32 , , , cord-280642-cvxni7cd 48 33 as as RB cord-280642-cvxni7cd 48 34 well well RB cord-280642-cvxni7cd 48 35 as as IN cord-280642-cvxni7cd 48 36 malignancy malignancy NN cord-280642-cvxni7cd 48 37 , , , cord-280642-cvxni7cd 48 38 dementia dementia NN cord-280642-cvxni7cd 48 39 and and CC cord-280642-cvxni7cd 48 40 obesity obesity NN cord-280642-cvxni7cd 48 41 ( ( -LRB- cord-280642-cvxni7cd 48 42 hazard hazard NN cord-280642-cvxni7cd 48 43 ratios ratio NNS cord-280642-cvxni7cd 48 44 1.19 1.19 CD cord-280642-cvxni7cd 48 45 - - SYM cord-280642-cvxni7cd 48 46 1.39 1.39 CD cord-280642-cvxni7cd 48 47 after after IN cord-280642-cvxni7cd 48 48 age age NN cord-280642-cvxni7cd 48 49 and and CC cord-280642-cvxni7cd 48 50 sex sex NN cord-280642-cvxni7cd 48 51 correction correction NN cord-280642-cvxni7cd 48 52 ) ) -RRB- cord-280642-cvxni7cd 48 53 . . . cord-280642-cvxni7cd 49 1 6 6 CD cord-280642-cvxni7cd 49 2 Obesity obesity NN cord-280642-cvxni7cd 49 3 has have VBZ cord-280642-cvxni7cd 49 4 been be VBN cord-280642-cvxni7cd 49 5 reported report VBN cord-280642-cvxni7cd 49 6 as as IN cord-280642-cvxni7cd 49 7 a a DT cord-280642-cvxni7cd 49 8 risk risk NN cord-280642-cvxni7cd 49 9 factor factor NN cord-280642-cvxni7cd 49 10 for for IN cord-280642-cvxni7cd 49 11 treatment treatment NN cord-280642-cvxni7cd 49 12 escalation escalation NN cord-280642-cvxni7cd 49 13 in in IN cord-280642-cvxni7cd 49 14 a a DT cord-280642-cvxni7cd 49 15 French french JJ cord-280642-cvxni7cd 49 16 ITU ITU NNP cord-280642-cvxni7cd 49 17 cohort cohort NN cord-280642-cvxni7cd 49 18 ( ( -LRB- cord-280642-cvxni7cd 49 19 n=124 n=124 CD cord-280642-cvxni7cd 49 20 ) ) -RRB- cord-280642-cvxni7cd 49 21 and and CC cord-280642-cvxni7cd 49 22 a a DT cord-280642-cvxni7cd 49 23 New New NNP cord-280642-cvxni7cd 49 24 York York NNP cord-280642-cvxni7cd 49 25 hospital hospital NN cord-280642-cvxni7cd 49 26 presentation presentation NN cord-280642-cvxni7cd 49 27 cohort cohort NN cord-280642-cvxni7cd 49 28 ( ( -LRB- cord-280642-cvxni7cd 49 29 n=3615 n=3615 UH cord-280642-cvxni7cd 49 30 ) ) -RRB- cord-280642-cvxni7cd 49 31 . . . cord-280642-cvxni7cd 50 1 7 7 CD cord-280642-cvxni7cd 50 2 , , , cord-280642-cvxni7cd 50 3 8 8 CD cord-280642-cvxni7cd 51 1 The the DT cord-280642-cvxni7cd 51 2 risks risk NNS cord-280642-cvxni7cd 51 3 associated associate VBN cord-280642-cvxni7cd 51 4 with with IN cord-280642-cvxni7cd 51 5 smoking smoking NN cord-280642-cvxni7cd 51 6 are be VBP cord-280642-cvxni7cd 51 7 disputed dispute VBN cord-280642-cvxni7cd 51 8 : : : cord-280642-cvxni7cd 51 9 increased increase VBN cord-280642-cvxni7cd 51 10 risks risk NNS cord-280642-cvxni7cd 51 11 were be VBD cord-280642-cvxni7cd 51 12 initially initially RB cord-280642-cvxni7cd 51 13 reported report VBN cord-280642-cvxni7cd 51 14 ; ; : cord-280642-cvxni7cd 51 15 recent recent JJ cord-280642-cvxni7cd 51 16 studies study NNS cord-280642-cvxni7cd 51 17 suggest suggest VBP cord-280642-cvxni7cd 51 18 that that IN cord-280642-cvxni7cd 51 19 smokers smoker NNS cord-280642-cvxni7cd 51 20 are be VBP cord-280642-cvxni7cd 51 21 underrepresented underrepresented JJ cord-280642-cvxni7cd 51 22 among among IN cord-280642-cvxni7cd 51 23 those those DT cord-280642-cvxni7cd 51 24 with with IN cord-280642-cvxni7cd 51 25 more more RBR cord-280642-cvxni7cd 51 26 severe severe JJ cord-280642-cvxni7cd 51 27 disease disease NN cord-280642-cvxni7cd 51 28 ; ; : cord-280642-cvxni7cd 51 29 and and CC cord-280642-cvxni7cd 51 30 a a DT cord-280642-cvxni7cd 51 31 potential potential JJ cord-280642-cvxni7cd 51 32 protective protective JJ cord-280642-cvxni7cd 51 33 mechanism mechanism NN cord-280642-cvxni7cd 51 34 for for IN cord-280642-cvxni7cd 51 35 nicotine nicotine NN cord-280642-cvxni7cd 51 36 has have VBZ cord-280642-cvxni7cd 51 37 been be VBN cord-280642-cvxni7cd 51 38 suggested suggest VBN cord-280642-cvxni7cd 51 39 . . . cord-280642-cvxni7cd 52 1 9 9 LS cord-280642-cvxni7cd 52 2 Smoking smoking NN cord-280642-cvxni7cd 52 3 prevalence prevalence NN cord-280642-cvxni7cd 52 4 among among IN cord-280642-cvxni7cd 52 5 hospitalised hospitalise VBN cord-280642-cvxni7cd 52 6 patients patient NNS cord-280642-cvxni7cd 52 7 was be VBD cord-280642-cvxni7cd 52 8 lower low JJR cord-280642-cvxni7cd 52 9 than than IN cord-280642-cvxni7cd 52 10 expected expect VBN cord-280642-cvxni7cd 52 11 in in IN cord-280642-cvxni7cd 52 12 China China NNP cord-280642-cvxni7cd 52 13 ( ( -LRB- cord-280642-cvxni7cd 52 14 1,099 1,099 CD cord-280642-cvxni7cd 52 15 patients patient NNS cord-280642-cvxni7cd 52 16 , , , cord-280642-cvxni7cd 52 17 12.6 12.6 CD cord-280642-cvxni7cd 52 18 % % NN cord-280642-cvxni7cd 52 19 vs vs IN cord-280642-cvxni7cd 52 20 28 28 CD cord-280642-cvxni7cd 52 21 % % NN cord-280642-cvxni7cd 52 22 in in IN cord-280642-cvxni7cd 52 23 the the DT cord-280642-cvxni7cd 52 24 general general JJ cord-280642-cvxni7cd 52 25 population population NNP cord-280642-cvxni7cd 52 26 ) ) -RRB- cord-280642-cvxni7cd 52 27 , , , cord-280642-cvxni7cd 52 28 10 10 CD cord-280642-cvxni7cd 52 29 and and CC cord-280642-cvxni7cd 52 30 in in IN cord-280642-cvxni7cd 52 31 a a DT cord-280642-cvxni7cd 52 32 small small JJ cord-280642-cvxni7cd 52 33 French french JJ cord-280642-cvxni7cd 52 34 study study NN cord-280642-cvxni7cd 52 35 ( ( -LRB- cord-280642-cvxni7cd 52 36 139 139 CD cord-280642-cvxni7cd 52 37 outpatients outpatient NNS cord-280642-cvxni7cd 52 38 and and CC cord-280642-cvxni7cd 52 39 343 343 CD cord-280642-cvxni7cd 52 40 inpatients inpatient NNS cord-280642-cvxni7cd 52 41 ; ; : cord-280642-cvxni7cd 52 42 Standardized standardized JJ cord-280642-cvxni7cd 52 43 Incidence Incidence NNP cord-280642-cvxni7cd 52 44 Ratios Ratios NNPS cord-280642-cvxni7cd 52 45 0.197 0.197 CD cord-280642-cvxni7cd 52 46 and and CC cord-280642-cvxni7cd 52 47 0.246 0.246 CD cord-280642-cvxni7cd 52 48 , , , cord-280642-cvxni7cd 52 49 respectively respectively RB cord-280642-cvxni7cd 52 50 ) ) -RRB- cord-280642-cvxni7cd 52 51 . . . cord-280642-cvxni7cd 53 1 11 11 CD cord-280642-cvxni7cd 53 2 People People NNS cord-280642-cvxni7cd 53 3 from from IN cord-280642-cvxni7cd 53 4 black black JJ cord-280642-cvxni7cd 53 5 and and CC cord-280642-cvxni7cd 53 6 minority minority NN cord-280642-cvxni7cd 53 7 ethnic ethnic JJ cord-280642-cvxni7cd 53 8 ( ( -LRB- cord-280642-cvxni7cd 53 9 BME BME NNP cord-280642-cvxni7cd 53 10 ) ) -RRB- cord-280642-cvxni7cd 53 11 groups group NNS cord-280642-cvxni7cd 53 12 are be VBP cord-280642-cvxni7cd 53 13 at at IN cord-280642-cvxni7cd 53 14 increased increase VBN cord-280642-cvxni7cd 53 15 risk risk NN cord-280642-cvxni7cd 53 16 of of IN cord-280642-cvxni7cd 53 17 bad bad JJ cord-280642-cvxni7cd 53 18 outcomes outcome NNS cord-280642-cvxni7cd 53 19 from from IN cord-280642-cvxni7cd 53 20 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 53 21 , , , cord-280642-cvxni7cd 53 22 but but CC cord-280642-cvxni7cd 53 23 explanations explanation NNS cord-280642-cvxni7cd 53 24 for for IN cord-280642-cvxni7cd 53 25 this this DT cord-280642-cvxni7cd 53 26 association association NN cord-280642-cvxni7cd 53 27 are be VBP cord-280642-cvxni7cd 53 28 unclear unclear JJ cord-280642-cvxni7cd 53 29 . . . cord-280642-cvxni7cd 54 1 12 12 CD cord-280642-cvxni7cd 54 2 , , , cord-280642-cvxni7cd 54 3 13 13 CD cord-280642-cvxni7cd 54 4 We -PRON- PRP cord-280642-cvxni7cd 54 5 therefore therefore RB cord-280642-cvxni7cd 54 6 set set VBD cord-280642-cvxni7cd 54 7 out out RP cord-280642-cvxni7cd 54 8 to to TO cord-280642-cvxni7cd 54 9 determine determine VB cord-280642-cvxni7cd 54 10 factors factor NNS cord-280642-cvxni7cd 54 11 associated associate VBN cord-280642-cvxni7cd 54 12 with with IN cord-280642-cvxni7cd 54 13 risk risk NN cord-280642-cvxni7cd 54 14 of of IN cord-280642-cvxni7cd 54 15 death death NN cord-280642-cvxni7cd 54 16 from from IN cord-280642-cvxni7cd 54 17 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 54 18 in in IN cord-280642-cvxni7cd 54 19 England England NNP cord-280642-cvxni7cd 54 20 using use VBG cord-280642-cvxni7cd 54 21 a a DT cord-280642-cvxni7cd 54 22 very very RB cord-280642-cvxni7cd 54 23 large large JJ cord-280642-cvxni7cd 54 24 sample sample NN cord-280642-cvxni7cd 54 25 of of IN cord-280642-cvxni7cd 54 26 the the DT cord-280642-cvxni7cd 54 27 adult adult NN cord-280642-cvxni7cd 54 28 population population NN cord-280642-cvxni7cd 54 29 , , , cord-280642-cvxni7cd 54 30 with with IN cord-280642-cvxni7cd 54 31 deaths death NNS cord-280642-cvxni7cd 54 32 data datum NNS cord-280642-cvxni7cd 54 33 linked link VBN cord-280642-cvxni7cd 54 34 to to IN cord-280642-cvxni7cd 54 35 longitudinal longitudinal JJ cord-280642-cvxni7cd 54 36 primary primary JJ cord-280642-cvxni7cd 54 37 care care NN cord-280642-cvxni7cd 54 38 electronic electronic JJ cord-280642-cvxni7cd 54 39 health health NN cord-280642-cvxni7cd 54 40 records record NNS cord-280642-cvxni7cd 54 41 . . . cord-280642-cvxni7cd 55 1 This this DT cord-280642-cvxni7cd 55 2 is be VBZ cord-280642-cvxni7cd 55 3 the the DT cord-280642-cvxni7cd 55 4 first first JJ cord-280642-cvxni7cd 55 5 iteration iteration NN cord-280642-cvxni7cd 55 6 , , , cord-280642-cvxni7cd 55 7 based base VBN cord-280642-cvxni7cd 55 8 on on IN cord-280642-cvxni7cd 55 9 the the DT cord-280642-cvxni7cd 55 10 currently currently RB cord-280642-cvxni7cd 55 11 available available JJ cord-280642-cvxni7cd 55 12 data datum NNS cord-280642-cvxni7cd 55 13 ; ; : cord-280642-cvxni7cd 55 14 further further JJ cord-280642-cvxni7cd 55 15 updates update NNS cord-280642-cvxni7cd 55 16 and and CC cord-280642-cvxni7cd 55 17 additional additional JJ cord-280642-cvxni7cd 55 18 outcomes outcome NNS cord-280642-cvxni7cd 55 19 will will MD cord-280642-cvxni7cd 55 20 be be VB cord-280642-cvxni7cd 55 21 released release VBN cord-280642-cvxni7cd 55 22 as as IN cord-280642-cvxni7cd 55 23 more more JJR cord-280642-cvxni7cd 55 24 data datum NNS cord-280642-cvxni7cd 55 25 become become VBP cord-280642-cvxni7cd 55 26 available available JJ cord-280642-cvxni7cd 55 27 through through IN cord-280642-cvxni7cd 55 28 the the DT cord-280642-cvxni7cd 55 29 OpenSAFELY.org opensafely.org CD cord-280642-cvxni7cd 55 30 platform platform NN cord-280642-cvxni7cd 55 31 . . . cord-280642-cvxni7cd 56 1 We -PRON- PRP cord-280642-cvxni7cd 56 2 conducted conduct VBD cord-280642-cvxni7cd 56 3 a a DT cord-280642-cvxni7cd 56 4 cohort cohort NN cord-280642-cvxni7cd 56 5 study study NN cord-280642-cvxni7cd 56 6 using use VBG cord-280642-cvxni7cd 56 7 national national JJ cord-280642-cvxni7cd 56 8 primary primary NNP cord-280642-cvxni7cd 56 9 care care NN cord-280642-cvxni7cd 56 10 electronic electronic JJ cord-280642-cvxni7cd 56 11 health health NN cord-280642-cvxni7cd 56 12 record record NN cord-280642-cvxni7cd 56 13 data datum NNS cord-280642-cvxni7cd 56 14 linked link VBN cord-280642-cvxni7cd 56 15 to to IN cord-280642-cvxni7cd 56 16 in in IN cord-280642-cvxni7cd 56 17 - - HYPH cord-280642-cvxni7cd 56 18 hospital hospital NN cord-280642-cvxni7cd 56 19 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 56 20 death death NN cord-280642-cvxni7cd 56 21 data datum NNS cord-280642-cvxni7cd 56 22 ( ( -LRB- cord-280642-cvxni7cd 56 23 see see VB cord-280642-cvxni7cd 56 24 Data Data NNP cord-280642-cvxni7cd 56 25 Source Source NNP cord-280642-cvxni7cd 56 26 ) ) -RRB- cord-280642-cvxni7cd 56 27 . . . cord-280642-cvxni7cd 57 1 The the DT cord-280642-cvxni7cd 57 2 cohort cohort NN cord-280642-cvxni7cd 57 3 study study NN cord-280642-cvxni7cd 57 4 began begin VBD cord-280642-cvxni7cd 57 5 on on IN cord-280642-cvxni7cd 57 6 1st 1st JJ cord-280642-cvxni7cd 57 7 February February NNP cord-280642-cvxni7cd 57 8 2020 2020 CD cord-280642-cvxni7cd 57 9 , , , cord-280642-cvxni7cd 57 10 chosen choose VBN cord-280642-cvxni7cd 57 11 as as IN cord-280642-cvxni7cd 57 12 a a DT cord-280642-cvxni7cd 57 13 date date NN cord-280642-cvxni7cd 57 14 several several JJ cord-280642-cvxni7cd 57 15 weeks week NNS cord-280642-cvxni7cd 57 16 prior prior RB cord-280642-cvxni7cd 57 17 to to IN cord-280642-cvxni7cd 57 18 the the DT cord-280642-cvxni7cd 57 19 first first JJ cord-280642-cvxni7cd 57 20 reported report VBN cord-280642-cvxni7cd 57 21 COVID-19 covid-19 CD cord-280642-cvxni7cd 57 22 deaths death NNS cord-280642-cvxni7cd 57 23 and and CC cord-280642-cvxni7cd 58 1 the the DT cord-280642-cvxni7cd 58 2 day day NN cord-280642-cvxni7cd 58 3 after after IN cord-280642-cvxni7cd 58 4 the the DT cord-280642-cvxni7cd 58 5 second second JJ cord-280642-cvxni7cd 58 6 laboratory laboratory NN cord-280642-cvxni7cd 58 7 confirmed confirm VBD cord-280642-cvxni7cd 58 8 case case NN cord-280642-cvxni7cd 58 9 ; ; : cord-280642-cvxni7cd 58 10 14 14 CD cord-280642-cvxni7cd 58 11 and and CC cord-280642-cvxni7cd 58 12 ended end VBD cord-280642-cvxni7cd 58 13 on on IN cord-280642-cvxni7cd 58 14 25th 25th JJ cord-280642-cvxni7cd 58 15 April April NNP cord-280642-cvxni7cd 58 16 2020 2020 CD cord-280642-cvxni7cd 58 17 . . . cord-280642-cvxni7cd 59 1 The the DT cord-280642-cvxni7cd 59 2 cohort cohort NN cord-280642-cvxni7cd 59 3 explores explore VBZ cord-280642-cvxni7cd 59 4 risk risk NN cord-280642-cvxni7cd 59 5 among among IN cord-280642-cvxni7cd 59 6 the the DT cord-280642-cvxni7cd 59 7 general general JJ cord-280642-cvxni7cd 59 8 population population NN cord-280642-cvxni7cd 59 9 rather rather RB cord-280642-cvxni7cd 59 10 than than IN cord-280642-cvxni7cd 59 11 in in IN cord-280642-cvxni7cd 59 12 a a DT cord-280642-cvxni7cd 59 13 population population NN cord-280642-cvxni7cd 59 14 infected infect VBN cord-280642-cvxni7cd 59 15 with with IN cord-280642-cvxni7cd 59 16 SARS SARS NNP cord-280642-cvxni7cd 59 17 - - HYPH cord-280642-cvxni7cd 59 18 COV-2 COV-2 NNP cord-280642-cvxni7cd 59 19 . . . cord-280642-cvxni7cd 60 1 Therefore therefore RB cord-280642-cvxni7cd 60 2 , , , cord-280642-cvxni7cd 60 3 all all DT cord-280642-cvxni7cd 60 4 patients patient NNS cord-280642-cvxni7cd 60 5 were be VBD cord-280642-cvxni7cd 60 6 included include VBN cord-280642-cvxni7cd 60 7 irrespective irrespective RB cord-280642-cvxni7cd 60 8 of of IN cord-280642-cvxni7cd 60 9 their -PRON- PRP$ cord-280642-cvxni7cd 60 10 SARS SARS NNP cord-280642-cvxni7cd 60 11 - - HYPH cord-280642-cvxni7cd 60 12 COV-2 COV-2 NNP cord-280642-cvxni7cd 60 13 test test NN cord-280642-cvxni7cd 60 14 results result NNS cord-280642-cvxni7cd 60 15 . . . cord-280642-cvxni7cd 61 1 We -PRON- PRP cord-280642-cvxni7cd 61 2 used use VBD cord-280642-cvxni7cd 61 3 patient patient JJ cord-280642-cvxni7cd 61 4 data datum NNS cord-280642-cvxni7cd 61 5 from from IN cord-280642-cvxni7cd 61 6 general general JJ cord-280642-cvxni7cd 61 7 practice practice NN cord-280642-cvxni7cd 61 8 ( ( -LRB- cord-280642-cvxni7cd 61 9 GP gp NN cord-280642-cvxni7cd 61 10 ) ) -RRB- cord-280642-cvxni7cd 61 11 records record NNS cord-280642-cvxni7cd 61 12 managed manage VBN cord-280642-cvxni7cd 61 13 by by IN cord-280642-cvxni7cd 61 14 the the DT cord-280642-cvxni7cd 61 15 GP GP NNP cord-280642-cvxni7cd 61 16 software software NN cord-280642-cvxni7cd 61 17 provider provider NN cord-280642-cvxni7cd 61 18 The the DT cord-280642-cvxni7cd 61 19 Phoenix Phoenix NNP cord-280642-cvxni7cd 61 20 Partnership Partnership NNP cord-280642-cvxni7cd 61 21 ( ( -LRB- cord-280642-cvxni7cd 61 22 TPP TPP NNP cord-280642-cvxni7cd 61 23 ) ) -RRB- cord-280642-cvxni7cd 61 24 , , , cord-280642-cvxni7cd 61 25 linked link VBN cord-280642-cvxni7cd 61 26 to to IN cord-280642-cvxni7cd 61 27 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 61 28 inpatient inpatient JJ cord-280642-cvxni7cd 61 29 hospital hospital NN cord-280642-cvxni7cd 61 30 death death NN cord-280642-cvxni7cd 61 31 notifications notification NNS cord-280642-cvxni7cd 61 32 ( ( -LRB- cord-280642-cvxni7cd 61 33 CPNS CPNS NNP cord-280642-cvxni7cd 61 34 ) ) -RRB- cord-280642-cvxni7cd 61 35 from from IN cord-280642-cvxni7cd 61 36 NHSE NHSE NNP cord-280642-cvxni7cd 61 37 / / SYM cord-280642-cvxni7cd 61 38 X X NNP cord-280642-cvxni7cd 61 39 , , , cord-280642-cvxni7cd 61 40 and and CC cord-280642-cvxni7cd 61 41 Office Office NNP cord-280642-cvxni7cd 61 42 for for IN cord-280642-cvxni7cd 61 43 National National NNP cord-280642-cvxni7cd 61 44 Statistics Statistics NNPS cord-280642-cvxni7cd 61 45 ( ( -LRB- cord-280642-cvxni7cd 61 46 ONS ONS NNP cord-280642-cvxni7cd 61 47 ) ) -RRB- cord-280642-cvxni7cd 61 48 death death NN cord-280642-cvxni7cd 61 49 data datum NNS cord-280642-cvxni7cd 61 50 . . . cord-280642-cvxni7cd 62 1 CPNS CPNS NNP cord-280642-cvxni7cd 62 2 provides provide VBZ cord-280642-cvxni7cd 62 3 the the DT cord-280642-cvxni7cd 62 4 most most RBS cord-280642-cvxni7cd 62 5 current current JJ cord-280642-cvxni7cd 62 6 information information NN cord-280642-cvxni7cd 62 7 on on IN cord-280642-cvxni7cd 62 8 deaths death NNS cord-280642-cvxni7cd 62 9 of of IN cord-280642-cvxni7cd 62 10 inpatients inpatient NNS cord-280642-cvxni7cd 62 11 . . . cord-280642-cvxni7cd 63 1 CC CC NNP cord-280642-cvxni7cd 63 2 - - : cord-280642-cvxni7cd 63 3 BY by IN cord-280642-cvxni7cd 63 4 4.0 4.0 CD cord-280642-cvxni7cd 63 5 International international JJ cord-280642-cvxni7cd 63 6 license license NN cord-280642-cvxni7cd 64 1 It -PRON- PRP cord-280642-cvxni7cd 64 2 is be VBZ cord-280642-cvxni7cd 64 3 made make VBN cord-280642-cvxni7cd 64 4 available available JJ cord-280642-cvxni7cd 64 5 under under IN cord-280642-cvxni7cd 64 6 a a DT cord-280642-cvxni7cd 65 1 is be VBZ cord-280642-cvxni7cd 65 2 the the DT cord-280642-cvxni7cd 65 3 author author NN cord-280642-cvxni7cd 65 4 / / SYM cord-280642-cvxni7cd 65 5 funder funder NN cord-280642-cvxni7cd 65 6 , , , cord-280642-cvxni7cd 65 7 who who WP cord-280642-cvxni7cd 65 8 has have VBZ cord-280642-cvxni7cd 65 9 granted grant VBN cord-280642-cvxni7cd 65 10 medRxiv medRxiv NNS cord-280642-cvxni7cd 65 11 a a DT cord-280642-cvxni7cd 65 12 license license NN cord-280642-cvxni7cd 65 13 to to TO cord-280642-cvxni7cd 65 14 display display VB cord-280642-cvxni7cd 65 15 the the DT cord-280642-cvxni7cd 65 16 preprint preprint NN cord-280642-cvxni7cd 65 17 in in IN cord-280642-cvxni7cd 65 18 perpetuity perpetuity NN cord-280642-cvxni7cd 65 19 . . . cord-280642-cvxni7cd 66 1 ( ( -LRB- cord-280642-cvxni7cd 66 2 which which WDT cord-280642-cvxni7cd 66 3 was be VBD cord-280642-cvxni7cd 66 4 not not RB cord-280642-cvxni7cd 66 5 certified certify VBN cord-280642-cvxni7cd 66 6 by by IN cord-280642-cvxni7cd 66 7 peer peer NN cord-280642-cvxni7cd 66 8 review review NN cord-280642-cvxni7cd 66 9 ) ) -RRB- cord-280642-cvxni7cd 67 1 The the DT cord-280642-cvxni7cd 67 2 copyright copyright NN cord-280642-cvxni7cd 67 3 holder holder NN cord-280642-cvxni7cd 67 4 for for IN cord-280642-cvxni7cd 67 5 this this DT cord-280642-cvxni7cd 67 6 preprint preprint NN cord-280642-cvxni7cd 67 7 this this DT cord-280642-cvxni7cd 67 8 version version NN cord-280642-cvxni7cd 67 9 posted post VBN cord-280642-cvxni7cd 67 10 May May NNP cord-280642-cvxni7cd 67 11 7 7 CD cord-280642-cvxni7cd 67 12 , , , cord-280642-cvxni7cd 67 13 2020 2020 CD cord-280642-cvxni7cd 67 14 . . . cord-280642-cvxni7cd 67 15 . . . cord-280642-cvxni7cd 68 1 https://doi.org/10.1101/2020.05.06.20092999 https://doi.org/10.1101/2020.05.06.20092999 NNP cord-280642-cvxni7cd 68 2 doi doi NNP cord-280642-cvxni7cd 68 3 : : : cord-280642-cvxni7cd 69 1 medRxiv medRxiv NNS cord-280642-cvxni7cd 69 2 preprint preprint NN cord-280642-cvxni7cd 69 3 with with IN cord-280642-cvxni7cd 69 4 laboratory laboratory NN cord-280642-cvxni7cd 69 5 confirmed confirm VBD cord-280642-cvxni7cd 69 6 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 69 7 occurring occur VBG cord-280642-cvxni7cd 69 8 within within IN cord-280642-cvxni7cd 69 9 NHS NHS NNP cord-280642-cvxni7cd 69 10 hospitals hospital NNS cord-280642-cvxni7cd 69 11 ; ; : cord-280642-cvxni7cd 69 12 15 15 CD cord-280642-cvxni7cd 69 13 , , , cord-280642-cvxni7cd 69 14 16 16 CD cord-280642-cvxni7cd 69 15 whereas whereas IN cord-280642-cvxni7cd 69 16 ONS ONS NNP cord-280642-cvxni7cd 69 17 includes include VBZ cord-280642-cvxni7cd 69 18 information information NN cord-280642-cvxni7cd 69 19 on on IN cord-280642-cvxni7cd 69 20 all all DT cord-280642-cvxni7cd 69 21 deaths death NNS cord-280642-cvxni7cd 69 22 , , , cord-280642-cvxni7cd 69 23 including include VBG cord-280642-cvxni7cd 69 24 those those DT cord-280642-cvxni7cd 69 25 due due JJ cord-280642-cvxni7cd 69 26 to to IN cord-280642-cvxni7cd 69 27 non non JJ cord-280642-cvxni7cd 69 28 - - JJ cord-280642-cvxni7cd 69 29 COVID-19 covid-19 JJ cord-280642-cvxni7cd 69 30 causes cause NNS cord-280642-cvxni7cd 69 31 , , , cord-280642-cvxni7cd 69 32 and and CC cord-280642-cvxni7cd 69 33 was be VBD cord-280642-cvxni7cd 69 34 used use VBN cord-280642-cvxni7cd 69 35 for for IN cord-280642-cvxni7cd 69 36 censoring censor VBG cord-280642-cvxni7cd 69 37 . . . cord-280642-cvxni7cd 70 1 The the DT cord-280642-cvxni7cd 70 2 data datum NNS cord-280642-cvxni7cd 70 3 were be VBD cord-280642-cvxni7cd 70 4 accessed access VBN cord-280642-cvxni7cd 70 5 , , , cord-280642-cvxni7cd 70 6 linked link VBN cord-280642-cvxni7cd 70 7 and and CC cord-280642-cvxni7cd 70 8 analysed analyse VBN cord-280642-cvxni7cd 70 9 using use VBG cord-280642-cvxni7cd 70 10 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 70 11 , , , cord-280642-cvxni7cd 70 12 a a DT cord-280642-cvxni7cd 70 13 new new JJ cord-280642-cvxni7cd 70 14 data data NN cord-280642-cvxni7cd 70 15 analytics analytic NNS cord-280642-cvxni7cd 70 16 platform platform NN cord-280642-cvxni7cd 70 17 created create VBN cord-280642-cvxni7cd 70 18 to to TO cord-280642-cvxni7cd 70 19 address address VB cord-280642-cvxni7cd 70 20 urgent urgent JJ cord-280642-cvxni7cd 70 21 questions question NNS cord-280642-cvxni7cd 70 22 relating relate VBG cord-280642-cvxni7cd 70 23 to to IN cord-280642-cvxni7cd 70 24 the the DT cord-280642-cvxni7cd 70 25 epidemiology epidemiology NN cord-280642-cvxni7cd 70 26 and and CC cord-280642-cvxni7cd 70 27 treatment treatment NN cord-280642-cvxni7cd 70 28 of of IN cord-280642-cvxni7cd 70 29 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 70 30 in in IN cord-280642-cvxni7cd 70 31 England England NNP cord-280642-cvxni7cd 70 32 . . . cord-280642-cvxni7cd 71 1 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 71 2 provides provide VBZ cord-280642-cvxni7cd 71 3 a a DT cord-280642-cvxni7cd 71 4 secure secure JJ cord-280642-cvxni7cd 71 5 software software NN cord-280642-cvxni7cd 71 6 interface interface NN cord-280642-cvxni7cd 71 7 that that WDT cord-280642-cvxni7cd 71 8 allows allow VBZ cord-280642-cvxni7cd 71 9 detailed detailed JJ cord-280642-cvxni7cd 71 10 pseudonymised pseudonymised JJ cord-280642-cvxni7cd 71 11 primary primary JJ cord-280642-cvxni7cd 71 12 care care NN cord-280642-cvxni7cd 71 13 patient patient NN cord-280642-cvxni7cd 71 14 records record NNS cord-280642-cvxni7cd 71 15 to to TO cord-280642-cvxni7cd 71 16 be be VB cord-280642-cvxni7cd 71 17 analysed analyse VBN cord-280642-cvxni7cd 71 18 in in IN cord-280642-cvxni7cd 71 19 near near JJ cord-280642-cvxni7cd 71 20 realtime realtime NN cord-280642-cvxni7cd 71 21 where where WRB cord-280642-cvxni7cd 71 22 they -PRON- PRP cord-280642-cvxni7cd 71 23 already already RB cord-280642-cvxni7cd 71 24 reside reside VBP cord-280642-cvxni7cd 71 25 , , , cord-280642-cvxni7cd 71 26 hosted host VBN cord-280642-cvxni7cd 71 27 within within IN cord-280642-cvxni7cd 71 28 the the DT cord-280642-cvxni7cd 71 29 EHR EHR NNP cord-280642-cvxni7cd 71 30 vendor vendor NN cord-280642-cvxni7cd 71 31 's 's POS cord-280642-cvxni7cd 71 32 highly highly RB cord-280642-cvxni7cd 71 33 secure secure JJ cord-280642-cvxni7cd 71 34 data data NN cord-280642-cvxni7cd 71 35 centre centre NN cord-280642-cvxni7cd 71 36 , , , cord-280642-cvxni7cd 71 37 to to TO cord-280642-cvxni7cd 71 38 minimise minimise VB cord-280642-cvxni7cd 71 39 the the DT cord-280642-cvxni7cd 71 40 re re NN cord-280642-cvxni7cd 71 41 - - NN cord-280642-cvxni7cd 71 42 identification identification NN cord-280642-cvxni7cd 71 43 risks risk NNS cord-280642-cvxni7cd 71 44 when when WRB cord-280642-cvxni7cd 71 45 data datum NNS cord-280642-cvxni7cd 71 46 are be VBP cord-280642-cvxni7cd 71 47 transported transport VBN cord-280642-cvxni7cd 71 48 off off IN cord-280642-cvxni7cd 71 49 - - HYPH cord-280642-cvxni7cd 71 50 site site NN cord-280642-cvxni7cd 71 51 ; ; : cord-280642-cvxni7cd 71 52 other other JJ cord-280642-cvxni7cd 71 53 smaller small JJR cord-280642-cvxni7cd 71 54 datasets dataset NNS cord-280642-cvxni7cd 71 55 are be VBP cord-280642-cvxni7cd 71 56 linked link VBN cord-280642-cvxni7cd 71 57 to to IN cord-280642-cvxni7cd 71 58 these these DT cord-280642-cvxni7cd 71 59 data datum NNS cord-280642-cvxni7cd 71 60 within within IN cord-280642-cvxni7cd 71 61 the the DT cord-280642-cvxni7cd 71 62 same same JJ cord-280642-cvxni7cd 71 63 environment environment NN cord-280642-cvxni7cd 71 64 using use VBG cord-280642-cvxni7cd 71 65 a a DT cord-280642-cvxni7cd 71 66 matching match VBG cord-280642-cvxni7cd 71 67 pseudonym pseudonym NN cord-280642-cvxni7cd 71 68 derived derive VBN cord-280642-cvxni7cd 71 69 from from IN cord-280642-cvxni7cd 71 70 the the DT cord-280642-cvxni7cd 71 71 NHS NHS NNP cord-280642-cvxni7cd 71 72 number number NN cord-280642-cvxni7cd 71 73 . . . cord-280642-cvxni7cd 72 1 More More JJR cord-280642-cvxni7cd 72 2 information information NN cord-280642-cvxni7cd 72 3 can can MD cord-280642-cvxni7cd 72 4 be be VB cord-280642-cvxni7cd 72 5 found find VBN cord-280642-cvxni7cd 72 6 on on IN cord-280642-cvxni7cd 72 7 https://opensafely.org/. https://opensafely.org/. NNP cord-280642-cvxni7cd 73 1 The the DT cord-280642-cvxni7cd 73 2 dataset dataset NN cord-280642-cvxni7cd 73 3 analysed analyse VBD cord-280642-cvxni7cd 73 4 with with IN cord-280642-cvxni7cd 73 5 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 73 6 for for IN cord-280642-cvxni7cd 73 7 this this DT cord-280642-cvxni7cd 73 8 paper paper NN cord-280642-cvxni7cd 73 9 is be VBZ cord-280642-cvxni7cd 73 10 based base VBN cord-280642-cvxni7cd 73 11 on on IN cord-280642-cvxni7cd 73 12 24 24 CD cord-280642-cvxni7cd 73 13 million million CD cord-280642-cvxni7cd 73 14 currently currently RB cord-280642-cvxni7cd 73 15 registered register VBN cord-280642-cvxni7cd 73 16 patients patient NNS cord-280642-cvxni7cd 73 17 ( ( -LRB- cord-280642-cvxni7cd 73 18 approximately approximately RB cord-280642-cvxni7cd 73 19 40 40 CD cord-280642-cvxni7cd 73 20 % % NN cord-280642-cvxni7cd 73 21 of of IN cord-280642-cvxni7cd 73 22 the the DT cord-280642-cvxni7cd 73 23 English english JJ cord-280642-cvxni7cd 73 24 population population NN cord-280642-cvxni7cd 73 25 ) ) -RRB- cord-280642-cvxni7cd 73 26 from from IN cord-280642-cvxni7cd 73 27 GP GP NNP cord-280642-cvxni7cd 73 28 surgeries surgery NNS cord-280642-cvxni7cd 73 29 using use VBG cord-280642-cvxni7cd 73 30 the the DT cord-280642-cvxni7cd 73 31 TPP TPP NNP cord-280642-cvxni7cd 73 32 SystmOne SystmOne NNP cord-280642-cvxni7cd 73 33 electronic electronic JJ cord-280642-cvxni7cd 73 34 health health NN cord-280642-cvxni7cd 73 35 record record NN cord-280642-cvxni7cd 73 36 system system NN cord-280642-cvxni7cd 73 37 . . . cord-280642-cvxni7cd 74 1 It -PRON- PRP cord-280642-cvxni7cd 74 2 extends extend VBZ cord-280642-cvxni7cd 74 3 to to IN cord-280642-cvxni7cd 74 4 20 20 CD cord-280642-cvxni7cd 74 5 billion billion CD cord-280642-cvxni7cd 74 6 rows row NNS cord-280642-cvxni7cd 74 7 of of IN cord-280642-cvxni7cd 74 8 structured structured JJ cord-280642-cvxni7cd 74 9 data datum NNS cord-280642-cvxni7cd 74 10 characterising characterise VBG cord-280642-cvxni7cd 74 11 ( ( -LRB- cord-280642-cvxni7cd 74 12 for for IN cord-280642-cvxni7cd 74 13 example example NN cord-280642-cvxni7cd 74 14 ) ) -RRB- cord-280642-cvxni7cd 74 15 pseudonymised pseudonymise VBD cord-280642-cvxni7cd 74 16 patients patient NNS cord-280642-cvxni7cd 74 17 ' ' POS cord-280642-cvxni7cd 74 18 diagnoses diagnosis NNS cord-280642-cvxni7cd 74 19 , , , cord-280642-cvxni7cd 74 20 medications medication NNS cord-280642-cvxni7cd 74 21 , , , cord-280642-cvxni7cd 74 22 physiological physiological JJ cord-280642-cvxni7cd 74 23 parameters parameter NNS cord-280642-cvxni7cd 74 24 , , , cord-280642-cvxni7cd 74 25 and and CC cord-280642-cvxni7cd 74 26 prior prior JJ cord-280642-cvxni7cd 74 27 investigations investigation NNS cord-280642-cvxni7cd 74 28 . . . cord-280642-cvxni7cd 75 1 Data datum NNS cord-280642-cvxni7cd 75 2 extracted extract VBN cord-280642-cvxni7cd 75 3 from from IN cord-280642-cvxni7cd 75 4 TPP TPP NNP cord-280642-cvxni7cd 75 5 SystmOne SystmOne NNP cord-280642-cvxni7cd 75 6 have have VBP cord-280642-cvxni7cd 75 7 previously previously RB cord-280642-cvxni7cd 75 8 been be VBN cord-280642-cvxni7cd 75 9 used use VBN cord-280642-cvxni7cd 75 10 in in IN cord-280642-cvxni7cd 75 11 medical medical JJ cord-280642-cvxni7cd 75 12 research research NN cord-280642-cvxni7cd 75 13 , , , cord-280642-cvxni7cd 75 14 as as IN cord-280642-cvxni7cd 75 15 part part NN cord-280642-cvxni7cd 75 16 of of IN cord-280642-cvxni7cd 75 17 the the DT cord-280642-cvxni7cd 75 18 ResearchOne ResearchOne NNP cord-280642-cvxni7cd 75 19 dataset dataset NN cord-280642-cvxni7cd 75 20 . . . cord-280642-cvxni7cd 76 1 17 17 CD cord-280642-cvxni7cd 76 2 , , , cord-280642-cvxni7cd 76 3 18 18 CD cord-280642-cvxni7cd 76 4 Study Study NNP cord-280642-cvxni7cd 76 5 Population Population NNP cord-280642-cvxni7cd 76 6 and and CC cord-280642-cvxni7cd 76 7 Observation Observation NNP cord-280642-cvxni7cd 76 8 Period Period NNP cord-280642-cvxni7cd 77 1 Our -PRON- PRP$ cord-280642-cvxni7cd 77 2 study study NN cord-280642-cvxni7cd 77 3 population population NN cord-280642-cvxni7cd 77 4 consisted consist VBD cord-280642-cvxni7cd 77 5 of of IN cord-280642-cvxni7cd 77 6 all all DT cord-280642-cvxni7cd 77 7 adults adult NNS cord-280642-cvxni7cd 77 8 ( ( -LRB- cord-280642-cvxni7cd 77 9 males male NNS cord-280642-cvxni7cd 77 10 and and CC cord-280642-cvxni7cd 77 11 females female NNS cord-280642-cvxni7cd 77 12 18 18 CD cord-280642-cvxni7cd 77 13 years year NNS cord-280642-cvxni7cd 77 14 and and CC cord-280642-cvxni7cd 77 15 above above RB cord-280642-cvxni7cd 77 16 ) ) -RRB- cord-280642-cvxni7cd 78 1 currently currently RB cord-280642-cvxni7cd 78 2 registered register VBN cord-280642-cvxni7cd 78 3 as as IN cord-280642-cvxni7cd 78 4 active active JJ cord-280642-cvxni7cd 78 5 patients patient NNS cord-280642-cvxni7cd 78 6 in in IN cord-280642-cvxni7cd 78 7 a a DT cord-280642-cvxni7cd 78 8 TPP TPP NNP cord-280642-cvxni7cd 78 9 general general JJ cord-280642-cvxni7cd 78 10 practice practice NN cord-280642-cvxni7cd 78 11 in in IN cord-280642-cvxni7cd 78 12 England England NNP cord-280642-cvxni7cd 78 13 on on IN cord-280642-cvxni7cd 78 14 1st 1st JJ cord-280642-cvxni7cd 78 15 February February NNP cord-280642-cvxni7cd 78 16 2020 2020 CD cord-280642-cvxni7cd 78 17 . . . cord-280642-cvxni7cd 79 1 To to TO cord-280642-cvxni7cd 79 2 be be VB cord-280642-cvxni7cd 79 3 included include VBN cord-280642-cvxni7cd 79 4 in in IN cord-280642-cvxni7cd 79 5 the the DT cord-280642-cvxni7cd 79 6 study study NN cord-280642-cvxni7cd 79 7 , , , cord-280642-cvxni7cd 79 8 participants participant NNS cord-280642-cvxni7cd 79 9 were be VBD cord-280642-cvxni7cd 79 10 required require VBN cord-280642-cvxni7cd 79 11 to to TO cord-280642-cvxni7cd 79 12 have have VB cord-280642-cvxni7cd 79 13 at at RB cord-280642-cvxni7cd 79 14 least least RBS cord-280642-cvxni7cd 79 15 1 1 CD cord-280642-cvxni7cd 79 16 year year NN cord-280642-cvxni7cd 79 17 of of IN cord-280642-cvxni7cd 79 18 prior prior JJ cord-280642-cvxni7cd 79 19 follow follow NN cord-280642-cvxni7cd 79 20 - - HYPH cord-280642-cvxni7cd 79 21 up up NN cord-280642-cvxni7cd 79 22 in in IN cord-280642-cvxni7cd 79 23 the the DT cord-280642-cvxni7cd 79 24 GP GP NNP cord-280642-cvxni7cd 79 25 practice practice NN cord-280642-cvxni7cd 79 26 to to TO cord-280642-cvxni7cd 79 27 ensure ensure VB cord-280642-cvxni7cd 79 28 that that IN cord-280642-cvxni7cd 79 29 baseline baseline JJ cord-280642-cvxni7cd 79 30 patient patient NN cord-280642-cvxni7cd 79 31 characteristics characteristic NNS cord-280642-cvxni7cd 79 32 could could MD cord-280642-cvxni7cd 79 33 be be VB cord-280642-cvxni7cd 79 34 adequately adequately RB cord-280642-cvxni7cd 79 35 captured capture VBN cord-280642-cvxni7cd 79 36 , , , cord-280642-cvxni7cd 79 37 and and CC cord-280642-cvxni7cd 79 38 to to TO cord-280642-cvxni7cd 79 39 have have VB cord-280642-cvxni7cd 79 40 a a DT cord-280642-cvxni7cd 79 41 recorded record VBN cord-280642-cvxni7cd 79 42 sex sex NN cord-280642-cvxni7cd 79 43 and and CC cord-280642-cvxni7cd 79 44 age age NN cord-280642-cvxni7cd 79 45 . . . cord-280642-cvxni7cd 80 1 19 19 CD cord-280642-cvxni7cd 80 2 Patients patient NNS cord-280642-cvxni7cd 80 3 were be VBD cord-280642-cvxni7cd 80 4 observed observe VBN cord-280642-cvxni7cd 80 5 from from IN cord-280642-cvxni7cd 80 6 the the DT cord-280642-cvxni7cd 80 7 1st 1st NN cord-280642-cvxni7cd 80 8 of of IN cord-280642-cvxni7cd 80 9 February February NNP cord-280642-cvxni7cd 80 10 2020 2020 CD cord-280642-cvxni7cd 80 11 and and CC cord-280642-cvxni7cd 80 12 were be VBD cord-280642-cvxni7cd 80 13 followed follow VBN cord-280642-cvxni7cd 80 14 until until IN cord-280642-cvxni7cd 80 15 the the DT cord-280642-cvxni7cd 80 16 first first JJ cord-280642-cvxni7cd 80 17 of of IN cord-280642-cvxni7cd 80 18 either either CC cord-280642-cvxni7cd 80 19 their -PRON- PRP$ cord-280642-cvxni7cd 80 20 death death NN cord-280642-cvxni7cd 80 21 date date NN cord-280642-cvxni7cd 80 22 ( ( -LRB- cord-280642-cvxni7cd 80 23 whether whether IN cord-280642-cvxni7cd 80 24 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 80 25 related related JJ cord-280642-cvxni7cd 80 26 or or CC cord-280642-cvxni7cd 80 27 due due JJ cord-280642-cvxni7cd 80 28 to to IN cord-280642-cvxni7cd 80 29 other other JJ cord-280642-cvxni7cd 80 30 causes cause NNS cord-280642-cvxni7cd 80 31 ) ) -RRB- cord-280642-cvxni7cd 80 32 or or CC cord-280642-cvxni7cd 80 33 the the DT cord-280642-cvxni7cd 80 34 study study NN cord-280642-cvxni7cd 80 35 end end NN cord-280642-cvxni7cd 80 36 date date NN cord-280642-cvxni7cd 80 37 , , , cord-280642-cvxni7cd 80 38 25th 25th JJ cord-280642-cvxni7cd 80 39 April April NNP cord-280642-cvxni7cd 80 40 2020 2020 CD cord-280642-cvxni7cd 80 41 . . . cord-280642-cvxni7cd 81 1 For for IN cord-280642-cvxni7cd 81 2 this this DT cord-280642-cvxni7cd 81 3 analysis analysis NN cord-280642-cvxni7cd 81 4 , , , cord-280642-cvxni7cd 81 5 CPNS CPNS NNP cord-280642-cvxni7cd 81 6 death death NN cord-280642-cvxni7cd 81 7 data datum NNS cord-280642-cvxni7cd 81 8 were be VBD cord-280642-cvxni7cd 81 9 available available JJ cord-280642-cvxni7cd 81 10 up up IN cord-280642-cvxni7cd 81 11 to to IN cord-280642-cvxni7cd 81 12 25th 25th JJ cord-280642-cvxni7cd 81 13 April April NNP cord-280642-cvxni7cd 81 14 2020 2020 CD cord-280642-cvxni7cd 81 15 ; ; : cord-280642-cvxni7cd 81 16 ONS ONS NNP cord-280642-cvxni7cd 81 17 death death NN cord-280642-cvxni7cd 81 18 data datum NNS cord-280642-cvxni7cd 81 19 ( ( -LRB- cord-280642-cvxni7cd 81 20 used use VBN cord-280642-cvxni7cd 81 21 for for IN cord-280642-cvxni7cd 81 22 censoring censor VBG cord-280642-cvxni7cd 81 23 individuals individual NNS cord-280642-cvxni7cd 81 24 who who WP cord-280642-cvxni7cd 81 25 died die VBD cord-280642-cvxni7cd 81 26 without without IN cord-280642-cvxni7cd 81 27 the the DT cord-280642-cvxni7cd 81 28 outcome outcome NN cord-280642-cvxni7cd 81 29 ) ) -RRB- cord-280642-cvxni7cd 81 30 were be VBD cord-280642-cvxni7cd 81 31 available available JJ cord-280642-cvxni7cd 81 32 to to IN cord-280642-cvxni7cd 81 33 16th 16th JJ cord-280642-cvxni7cd 81 34 April April NNP cord-280642-cvxni7cd 81 35 2020 2020 CD cord-280642-cvxni7cd 81 36 ; ; , cord-280642-cvxni7cd 81 37 patient patient JJ cord-280642-cvxni7cd 81 38 censoring censoring NN cord-280642-cvxni7cd 81 39 for for IN cord-280642-cvxni7cd 81 40 deaths death NNS cord-280642-cvxni7cd 81 41 due due JJ cord-280642-cvxni7cd 81 42 to to IN cord-280642-cvxni7cd 81 43 other other JJ cord-280642-cvxni7cd 81 44 causes cause NNS cord-280642-cvxni7cd 81 45 was be VBD cord-280642-cvxni7cd 81 46 therefore therefore RB cord-280642-cvxni7cd 81 47 not not RB cord-280642-cvxni7cd 81 48 possible possible JJ cord-280642-cvxni7cd 81 49 during during IN cord-280642-cvxni7cd 81 50 the the DT cord-280642-cvxni7cd 81 51 last last JJ cord-280642-cvxni7cd 81 52 9 9 CD cord-280642-cvxni7cd 81 53 days day NNS cord-280642-cvxni7cd 81 54 of of IN cord-280642-cvxni7cd 81 55 followup followup NN cord-280642-cvxni7cd 81 56 ( ( -LRB- cord-280642-cvxni7cd 81 57 see see VB cord-280642-cvxni7cd 81 58 Discussion Discussion NNP cord-280642-cvxni7cd 81 59 , , , cord-280642-cvxni7cd 81 60 weaknesses weakness NNS cord-280642-cvxni7cd 81 61 ; ; : cord-280642-cvxni7cd 81 62 a a DT cord-280642-cvxni7cd 81 63 sensitivity sensitivity NN cord-280642-cvxni7cd 81 64 analysis analysis NN cord-280642-cvxni7cd 81 65 is be VBZ cord-280642-cvxni7cd 81 66 presented present VBN cord-280642-cvxni7cd 81 67 with with IN cord-280642-cvxni7cd 81 68 all all DT cord-280642-cvxni7cd 81 69 data datum NNS cord-280642-cvxni7cd 81 70 censored censor VBN cord-280642-cvxni7cd 81 71 at at IN cord-280642-cvxni7cd 81 72 6th 6th JJ cord-280642-cvxni7cd 81 73 April April NNP cord-280642-cvxni7cd 81 74 2020 2020 CD cord-280642-cvxni7cd 81 75 in in IN cord-280642-cvxni7cd 81 76 appendix appendix NNP cord-280642-cvxni7cd 81 77 Table Table NNP cord-280642-cvxni7cd 81 78 A1 A1 NNP cord-280642-cvxni7cd 81 79 ) ) -RRB- cord-280642-cvxni7cd 81 80 . . . cord-280642-cvxni7cd 82 1 The the DT cord-280642-cvxni7cd 82 2 outcome outcome NN cord-280642-cvxni7cd 82 3 was be VBD cord-280642-cvxni7cd 82 4 in in IN cord-280642-cvxni7cd 82 5 - - HYPH cord-280642-cvxni7cd 82 6 hospital hospital NN cord-280642-cvxni7cd 82 7 death death NN cord-280642-cvxni7cd 82 8 among among IN cord-280642-cvxni7cd 82 9 people people NNS cord-280642-cvxni7cd 82 10 with with IN cord-280642-cvxni7cd 82 11 confirmed confirm VBN cord-280642-cvxni7cd 82 12 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 82 13 , , , cord-280642-cvxni7cd 82 14 ascertained ascertain VBD cord-280642-cvxni7cd 82 15 from from IN cord-280642-cvxni7cd 82 16 the the DT cord-280642-cvxni7cd 82 17 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 82 18 Patient Patient NNP cord-280642-cvxni7cd 82 19 Notification Notification NNP cord-280642-cvxni7cd 82 20 System System NNP cord-280642-cvxni7cd 82 21 ( ( -LRB- cord-280642-cvxni7cd 82 22 CPNS CPNS NNP cord-280642-cvxni7cd 82 23 ) ) -RRB- cord-280642-cvxni7cd 82 24 . . . cord-280642-cvxni7cd 83 1 Potential potential JJ cord-280642-cvxni7cd 83 2 risk risk NN cord-280642-cvxni7cd 83 3 factors factor NNS cord-280642-cvxni7cd 83 4 included include VBD cord-280642-cvxni7cd 83 5 : : : cord-280642-cvxni7cd 83 6 health health NN cord-280642-cvxni7cd 83 7 conditions condition NNS cord-280642-cvxni7cd 83 8 listed list VBN cord-280642-cvxni7cd 83 9 in in IN cord-280642-cvxni7cd 83 10 UK UK NNP cord-280642-cvxni7cd 83 11 guidance guidance NN cord-280642-cvxni7cd 83 12 on on IN cord-280642-cvxni7cd 83 13 " " `` cord-280642-cvxni7cd 83 14 higher high JJR cord-280642-cvxni7cd 83 15 risk risk NN cord-280642-cvxni7cd 83 16 " " '' cord-280642-cvxni7cd 83 17 groups group NNS cord-280642-cvxni7cd 83 18 ; ; : cord-280642-cvxni7cd 83 19 20 20 CD cord-280642-cvxni7cd 83 20 other other JJ cord-280642-cvxni7cd 83 21 common common JJ cord-280642-cvxni7cd 83 22 conditions condition NNS cord-280642-cvxni7cd 83 23 which which WDT cord-280642-cvxni7cd 83 24 may may MD cord-280642-cvxni7cd 83 25 cause cause VB cord-280642-cvxni7cd 83 26 immunodeficiency immunodeficiency NN cord-280642-cvxni7cd 83 27 inherently inherently RB cord-280642-cvxni7cd 83 28 or or CC cord-280642-cvxni7cd 83 29 through through IN cord-280642-cvxni7cd 83 30 medication medication NN cord-280642-cvxni7cd 83 31 ( ( -LRB- cord-280642-cvxni7cd 83 32 cancer cancer NN cord-280642-cvxni7cd 83 33 and and CC cord-280642-cvxni7cd 83 34 common common JJ cord-280642-cvxni7cd 83 35 autoimmune autoimmune JJ cord-280642-cvxni7cd 83 36 conditions condition NNS cord-280642-cvxni7cd 83 37 ) ) -RRB- cord-280642-cvxni7cd 83 38 ; ; : cord-280642-cvxni7cd 83 39 and and CC cord-280642-cvxni7cd 83 40 emerging emerge VBG cord-280642-cvxni7cd 83 41 risk risk NN cord-280642-cvxni7cd 83 42 factors factor NNS cord-280642-cvxni7cd 83 43 for for IN cord-280642-cvxni7cd 83 44 severe severe JJ cord-280642-cvxni7cd 83 45 outcomes outcome NNS cord-280642-cvxni7cd 83 46 among among IN cord-280642-cvxni7cd 83 47 COVID-19 covid-19 JJ cord-280642-cvxni7cd 83 48 cases case NNS cord-280642-cvxni7cd 83 49 ( ( -LRB- cord-280642-cvxni7cd 83 50 such such JJ cord-280642-cvxni7cd 83 51 as as IN cord-280642-cvxni7cd 83 52 raised raise VBN cord-280642-cvxni7cd 83 53 blood blood NN cord-280642-cvxni7cd 83 54 pressure pressure NN cord-280642-cvxni7cd 83 55 ) ) -RRB- cord-280642-cvxni7cd 83 56 . . . cord-280642-cvxni7cd 84 1 Age age NN cord-280642-cvxni7cd 84 2 , , , cord-280642-cvxni7cd 84 3 sex sex NN cord-280642-cvxni7cd 84 4 , , , cord-280642-cvxni7cd 84 5 body body NN cord-280642-cvxni7cd 84 6 mass mass NN cord-280642-cvxni7cd 84 7 index index NN cord-280642-cvxni7cd 84 8 ( ( -LRB- cord-280642-cvxni7cd 84 9 BMI BMI NNP cord-280642-cvxni7cd 84 10 ; ; : cord-280642-cvxni7cd 84 11 kg kg NNP cord-280642-cvxni7cd 84 12 / / SYM cord-280642-cvxni7cd 84 13 m m NN cord-280642-cvxni7cd 84 14 2 2 CD cord-280642-cvxni7cd 84 15 ) ) -RRB- cord-280642-cvxni7cd 84 16 , , , cord-280642-cvxni7cd 84 17 and and CC cord-280642-cvxni7cd 84 18 smoking smoking NN cord-280642-cvxni7cd 84 19 status status NN cord-280642-cvxni7cd 84 20 were be VBD cord-280642-cvxni7cd 84 21 considered consider VBN cord-280642-cvxni7cd 84 22 as as IN cord-280642-cvxni7cd 84 23 potential potential JJ cord-280642-cvxni7cd 84 24 risk risk NN cord-280642-cvxni7cd 84 25 factors factor NNS cord-280642-cvxni7cd 84 26 . . . cord-280642-cvxni7cd 85 1 Where where WRB cord-280642-cvxni7cd 85 2 categorised categorise VBN cord-280642-cvxni7cd 85 3 , , , cord-280642-cvxni7cd 85 4 age age NN cord-280642-cvxni7cd 85 5 groups group NNS cord-280642-cvxni7cd 85 6 were be VBD cord-280642-cvxni7cd 85 7 : : : cord-280642-cvxni7cd 85 8 18-<40 18-<40 CD cord-280642-cvxni7cd 85 9 , , , cord-280642-cvxni7cd 85 10 40-<50 40-<50 CD cord-280642-cvxni7cd 85 11 , , , cord-280642-cvxni7cd 85 12 50-<60 50-<60 NNP cord-280642-cvxni7cd 85 13 , , , cord-280642-cvxni7cd 85 14 60-<70 60-<70 CD cord-280642-cvxni7cd 85 15 , , , cord-280642-cvxni7cd 85 16 70-<80 70-<80 CD cord-280642-cvxni7cd 85 17 , , , cord-280642-cvxni7cd 86 1 80 80 CD cord-280642-cvxni7cd 86 2 + + SYM cord-280642-cvxni7cd 86 3 years year NNS cord-280642-cvxni7cd 86 4 . . . cord-280642-cvxni7cd 87 1 BMI BMI NNP cord-280642-cvxni7cd 87 2 was be VBD cord-280642-cvxni7cd 87 3 ascertained ascertain VBN cord-280642-cvxni7cd 87 4 from from IN cord-280642-cvxni7cd 87 5 weight weight NN cord-280642-cvxni7cd 87 6 measurements measurement NNS cord-280642-cvxni7cd 87 7 within within IN cord-280642-cvxni7cd 87 8 the the DT cord-280642-cvxni7cd 87 9 last last JJ cord-280642-cvxni7cd 87 10 10 10 CD cord-280642-cvxni7cd 87 11 years year NNS cord-280642-cvxni7cd 87 12 , , , cord-280642-cvxni7cd 87 13 restricted restrict VBN cord-280642-cvxni7cd 87 14 to to IN cord-280642-cvxni7cd 87 15 those those DT cord-280642-cvxni7cd 87 16 taken take VBN cord-280642-cvxni7cd 87 17 when when WRB cord-280642-cvxni7cd 87 18 the the DT cord-280642-cvxni7cd 87 19 patient patient NN cord-280642-cvxni7cd 87 20 was be VBD cord-280642-cvxni7cd 87 21 over over IN cord-280642-cvxni7cd 87 22 16 16 CD cord-280642-cvxni7cd 87 23 years year NNS cord-280642-cvxni7cd 87 24 old old JJ cord-280642-cvxni7cd 87 25 . . . cord-280642-cvxni7cd 88 1 Obesity obesity NN cord-280642-cvxni7cd 88 2 was be VBD cord-280642-cvxni7cd 88 3 grouped group VBN cord-280642-cvxni7cd 88 4 using use VBG cord-280642-cvxni7cd 88 5 categories category NNS cord-280642-cvxni7cd 88 6 derived derive VBN cord-280642-cvxni7cd 88 7 from from IN cord-280642-cvxni7cd 88 8 the the DT cord-280642-cvxni7cd 88 9 World World NNP cord-280642-cvxni7cd 88 10 Health Health NNP cord-280642-cvxni7cd 88 11 Organisation Organisation NNP cord-280642-cvxni7cd 88 12 classification classification NN cord-280642-cvxni7cd 88 13 of of IN cord-280642-cvxni7cd 88 14 BMI BMI NNP cord-280642-cvxni7cd 88 15 : : : cord-280642-cvxni7cd 88 16 no no DT cord-280642-cvxni7cd 88 17 evidence evidence NN cord-280642-cvxni7cd 88 18 of of IN cord-280642-cvxni7cd 88 19 obesity obesity NN cord-280642-cvxni7cd 88 20 < < XX cord-280642-cvxni7cd 88 21 30 30 CD cord-280642-cvxni7cd 88 22 kg kg NN cord-280642-cvxni7cd 88 23 / / SYM cord-280642-cvxni7cd 88 24 m m NN cord-280642-cvxni7cd 88 25 2 2 CD cord-280642-cvxni7cd 88 26 ; ; , cord-280642-cvxni7cd 88 27 obese obese JJ cord-280642-cvxni7cd 88 28 I -PRON- PRP cord-280642-cvxni7cd 88 29 30 30 CD cord-280642-cvxni7cd 88 30 - - HYPH cord-280642-cvxni7cd 88 31 34.9 34.9 CD cord-280642-cvxni7cd 88 32 ; ; : cord-280642-cvxni7cd 88 33 obese obese JJ cord-280642-cvxni7cd 88 34 II ii CD cord-280642-cvxni7cd 88 35 35 35 CD cord-280642-cvxni7cd 88 36 - - HYPH cord-280642-cvxni7cd 88 37 39.9 39.9 CD cord-280642-cvxni7cd 88 38 ; ; : cord-280642-cvxni7cd 88 39 obese obese JJ cord-280642-cvxni7cd 88 40 III iii CD cord-280642-cvxni7cd 88 41 40 40 CD cord-280642-cvxni7cd 89 1 + + UH cord-280642-cvxni7cd 89 2 . . . cord-280642-cvxni7cd 90 1 Smoking smoking NN cord-280642-cvxni7cd 90 2 status status NN cord-280642-cvxni7cd 90 3 was be VBD cord-280642-cvxni7cd 90 4 grouped group VBN cord-280642-cvxni7cd 90 5 into into IN cord-280642-cvxni7cd 90 6 current current JJ cord-280642-cvxni7cd 90 7 , , , cord-280642-cvxni7cd 90 8 former former JJ cord-280642-cvxni7cd 90 9 and and CC cord-280642-cvxni7cd 90 10 never never RB cord-280642-cvxni7cd 90 11 smokers smoker NNS cord-280642-cvxni7cd 91 1 The the DT cord-280642-cvxni7cd 91 2 following following JJ cord-280642-cvxni7cd 91 3 comorbidities comorbiditie NNS cord-280642-cvxni7cd 91 4 were be VBD cord-280642-cvxni7cd 91 5 also also RB cord-280642-cvxni7cd 91 6 considered consider VBN cord-280642-cvxni7cd 91 7 potential potential JJ cord-280642-cvxni7cd 91 8 risk risk NN cord-280642-cvxni7cd 91 9 factors factor NNS cord-280642-cvxni7cd 91 10 : : : cord-280642-cvxni7cd 91 11 asthma asthma NN cord-280642-cvxni7cd 91 12 , , , cord-280642-cvxni7cd 91 13 other other JJ cord-280642-cvxni7cd 91 14 chronic chronic JJ cord-280642-cvxni7cd 91 15 respiratory respiratory JJ cord-280642-cvxni7cd 91 16 disease disease NN cord-280642-cvxni7cd 91 17 , , , cord-280642-cvxni7cd 91 18 chronic chronic JJ cord-280642-cvxni7cd 91 19 heart heart NN cord-280642-cvxni7cd 91 20 disease disease NN cord-280642-cvxni7cd 91 21 , , , cord-280642-cvxni7cd 91 22 diabetes diabetes NN cord-280642-cvxni7cd 91 23 mellitus mellitus NN cord-280642-cvxni7cd 91 24 , , , cord-280642-cvxni7cd 91 25 chronic chronic JJ cord-280642-cvxni7cd 91 26 liver liver NN cord-280642-cvxni7cd 91 27 disease disease NN cord-280642-cvxni7cd 91 28 , , , cord-280642-cvxni7cd 91 29 chronic chronic JJ cord-280642-cvxni7cd 91 30 neurological neurological JJ cord-280642-cvxni7cd 91 31 diseases disease NNS cord-280642-cvxni7cd 91 32 , , , cord-280642-cvxni7cd 91 33 common common JJ cord-280642-cvxni7cd 91 34 autoimmune autoimmune JJ cord-280642-cvxni7cd 91 35 diseases disease NNS cord-280642-cvxni7cd 91 36 ( ( -LRB- cord-280642-cvxni7cd 91 37 Rheumatoid Rheumatoid NNP cord-280642-cvxni7cd 91 38 Arthritis arthritis NN cord-280642-cvxni7cd 91 39 ( ( -LRB- cord-280642-cvxni7cd 91 40 RA RA NNP cord-280642-cvxni7cd 91 41 ) ) -RRB- cord-280642-cvxni7cd 91 42 , , . cord-280642-cvxni7cd 92 1 Systemic systemic JJ cord-280642-cvxni7cd 92 2 Lupus Lupus NNP cord-280642-cvxni7cd 92 3 Erythematosus Erythematosus NNP cord-280642-cvxni7cd 92 4 ( ( -LRB- cord-280642-cvxni7cd 92 5 SLE SLE NNP cord-280642-cvxni7cd 92 6 ) ) -RRB- cord-280642-cvxni7cd 92 7 or or CC cord-280642-cvxni7cd 92 8 psoriasis psoriasis NN cord-280642-cvxni7cd 92 9 ) ) -RRB- cord-280642-cvxni7cd 92 10 , , , cord-280642-cvxni7cd 92 11 solid solid JJ cord-280642-cvxni7cd 92 12 organ organ NN cord-280642-cvxni7cd 92 13 transplant transplant NN cord-280642-cvxni7cd 92 14 , , , cord-280642-cvxni7cd 92 15 asplenia asplenia NN cord-280642-cvxni7cd 92 16 , , , cord-280642-cvxni7cd 92 17 other other JJ cord-280642-cvxni7cd 92 18 immunosuppressive immunosuppressive JJ cord-280642-cvxni7cd 92 19 conditions condition NNS cord-280642-cvxni7cd 92 20 , , , cord-280642-cvxni7cd 92 21 cancer cancer NN cord-280642-cvxni7cd 92 22 , , , cord-280642-cvxni7cd 92 23 evidence evidence NN cord-280642-cvxni7cd 92 24 of of IN cord-280642-cvxni7cd 92 25 reduced reduce VBN cord-280642-cvxni7cd 92 26 kidney kidney NN cord-280642-cvxni7cd 92 27 function function NN cord-280642-cvxni7cd 92 28 , , , cord-280642-cvxni7cd 92 29 and and CC cord-280642-cvxni7cd 92 30 raised raise VBD cord-280642-cvxni7cd 92 31 blood blood NN cord-280642-cvxni7cd 92 32 pressure pressure NN cord-280642-cvxni7cd 92 33 or or CC cord-280642-cvxni7cd 92 34 a a DT cord-280642-cvxni7cd 92 35 diagnosis diagnosis NN cord-280642-cvxni7cd 92 36 of of IN cord-280642-cvxni7cd 92 37 hypertension hypertension NN cord-280642-cvxni7cd 92 38 . . . cord-280642-cvxni7cd 93 1 Disease Disease NNP cord-280642-cvxni7cd 93 2 groupings grouping NNS cord-280642-cvxni7cd 93 3 followed follow VBD cord-280642-cvxni7cd 93 4 national national JJ cord-280642-cvxni7cd 93 5 guidance guidance NN cord-280642-cvxni7cd 93 6 on on IN cord-280642-cvxni7cd 93 7 risk risk NN cord-280642-cvxni7cd 93 8 of of IN cord-280642-cvxni7cd 93 9 influenza influenza NN cord-280642-cvxni7cd 93 10 infection infection NN cord-280642-cvxni7cd 93 11 , , , cord-280642-cvxni7cd 93 12 21 21 CD cord-280642-cvxni7cd 93 13 therefore therefore RB cord-280642-cvxni7cd 93 14 " " `` cord-280642-cvxni7cd 93 15 chronic chronic JJ cord-280642-cvxni7cd 93 16 respiratory respiratory JJ cord-280642-cvxni7cd 93 17 disease disease NN cord-280642-cvxni7cd 93 18 ( ( -LRB- cord-280642-cvxni7cd 93 19 other other JJ cord-280642-cvxni7cd 93 20 than than IN cord-280642-cvxni7cd 93 21 asthma asthma NN cord-280642-cvxni7cd 93 22 ) ) -RRB- cord-280642-cvxni7cd 93 23 " " '' cord-280642-cvxni7cd 93 24 included include VBD cord-280642-cvxni7cd 93 25 COPD COPD NNP cord-280642-cvxni7cd 93 26 , , , cord-280642-cvxni7cd 93 27 fibrosing fibrose VBG cord-280642-cvxni7cd 93 28 lung lung NN cord-280642-cvxni7cd 93 29 disease disease NN cord-280642-cvxni7cd 93 30 , , , cord-280642-cvxni7cd 93 31 bronchiectasis bronchiectasis NN cord-280642-cvxni7cd 93 32 or or CC cord-280642-cvxni7cd 93 33 cystic cystic JJ cord-280642-cvxni7cd 93 34 fibrosis fibrosis NN cord-280642-cvxni7cd 93 35 ; ; : cord-280642-cvxni7cd 93 36 chronic chronic JJ cord-280642-cvxni7cd 93 37 heart heart NN cord-280642-cvxni7cd 93 38 disease disease NN cord-280642-cvxni7cd 93 39 included include VBD cord-280642-cvxni7cd 93 40 chronic chronic JJ cord-280642-cvxni7cd 93 41 heart heart NN cord-280642-cvxni7cd 93 42 failure failure NN cord-280642-cvxni7cd 93 43 , , , cord-280642-cvxni7cd 93 44 ischaemic ischaemic JJ cord-280642-cvxni7cd 93 45 heart heart NN cord-280642-cvxni7cd 93 46 disease disease NN cord-280642-cvxni7cd 93 47 , , , cord-280642-cvxni7cd 93 48 and and CC cord-280642-cvxni7cd 93 49 severe severe JJ cord-280642-cvxni7cd 93 50 valve valve NN cord-280642-cvxni7cd 93 51 or or CC cord-280642-cvxni7cd 93 52 congenital congenital JJ cord-280642-cvxni7cd 93 53 heart heart NN cord-280642-cvxni7cd 93 54 disease disease NN cord-280642-cvxni7cd 93 55 likely likely JJ cord-280642-cvxni7cd 93 56 to to TO cord-280642-cvxni7cd 93 57 require require VB cord-280642-cvxni7cd 93 58 lifelong lifelong JJ cord-280642-cvxni7cd 93 59 follow follow VB cord-280642-cvxni7cd 93 60 up up RP cord-280642-cvxni7cd 93 61 . . . cord-280642-cvxni7cd 94 1 Chronic chronic JJ cord-280642-cvxni7cd 94 2 neurological neurological JJ cord-280642-cvxni7cd 94 3 conditions condition NNS cord-280642-cvxni7cd 94 4 were be VBD cord-280642-cvxni7cd 94 5 separated separate VBN cord-280642-cvxni7cd 94 6 into into IN cord-280642-cvxni7cd 94 7 diseases disease NNS cord-280642-cvxni7cd 94 8 with with IN cord-280642-cvxni7cd 94 9 a a DT cord-280642-cvxni7cd 94 10 likely likely JJ cord-280642-cvxni7cd 94 11 cardiovascular cardiovascular JJ cord-280642-cvxni7cd 94 12 aetiology aetiology NN cord-280642-cvxni7cd 94 13 ( ( -LRB- cord-280642-cvxni7cd 94 14 stroke stroke NN cord-280642-cvxni7cd 94 15 , , , cord-280642-cvxni7cd 94 16 TIA TIA NNP cord-280642-cvxni7cd 94 17 , , , cord-280642-cvxni7cd 94 18 dementia dementia NN cord-280642-cvxni7cd 94 19 ) ) -RRB- cord-280642-cvxni7cd 94 20 and and CC cord-280642-cvxni7cd 94 21 conditions condition NNS cord-280642-cvxni7cd 94 22 in in IN cord-280642-cvxni7cd 94 23 which which WDT cord-280642-cvxni7cd 94 24 respiratory respiratory JJ cord-280642-cvxni7cd 94 25 function function NN cord-280642-cvxni7cd 94 26 may may MD cord-280642-cvxni7cd 94 27 be be VB cord-280642-cvxni7cd 94 28 compromised compromise VBN cord-280642-cvxni7cd 94 29 such such JJ cord-280642-cvxni7cd 94 30 as as IN cord-280642-cvxni7cd 94 31 motor motor NN cord-280642-cvxni7cd 94 32 neurone neurone NN cord-280642-cvxni7cd 94 33 disease disease NN cord-280642-cvxni7cd 94 34 , , , cord-280642-cvxni7cd 94 35 myasthenia myasthenia NN cord-280642-cvxni7cd 94 36 gravis gravis NN cord-280642-cvxni7cd 94 37 , , , cord-280642-cvxni7cd 94 38 multiple multiple JJ cord-280642-cvxni7cd 94 39 sclerosis sclerosis NN cord-280642-cvxni7cd 94 40 , , , cord-280642-cvxni7cd 94 41 Parkinson Parkinson NNP cord-280642-cvxni7cd 94 42 's 's POS cord-280642-cvxni7cd 94 43 disease disease NN cord-280642-cvxni7cd 94 44 , , , cord-280642-cvxni7cd 94 45 cerebral cerebral JJ cord-280642-cvxni7cd 94 46 palsy palsy NN cord-280642-cvxni7cd 94 47 , , , cord-280642-cvxni7cd 94 48 quadriplegia quadriplegia NNP cord-280642-cvxni7cd 94 49 or or CC cord-280642-cvxni7cd 94 50 hemiplegia hemiplegia NN cord-280642-cvxni7cd 94 51 , , , cord-280642-cvxni7cd 94 52 malignant malignant JJ cord-280642-cvxni7cd 94 53 primary primary JJ cord-280642-cvxni7cd 94 54 brain brain NN cord-280642-cvxni7cd 94 55 tumour tumour NN cord-280642-cvxni7cd 94 56 , , , cord-280642-cvxni7cd 94 57 and and CC cord-280642-cvxni7cd 94 58 progressive progressive JJ cord-280642-cvxni7cd 94 59 cerebellar cerebellar JJ cord-280642-cvxni7cd 94 60 disease disease NN cord-280642-cvxni7cd 94 61 . . . cord-280642-cvxni7cd 95 1 Asplenia asplenia NN cord-280642-cvxni7cd 95 2 included include VBD cord-280642-cvxni7cd 95 3 splenectomy splenectomy NN cord-280642-cvxni7cd 95 4 or or CC cord-280642-cvxni7cd 95 5 a a DT cord-280642-cvxni7cd 95 6 spleen spleen NN cord-280642-cvxni7cd 95 7 dysfunction dysfunction NN cord-280642-cvxni7cd 95 8 , , , cord-280642-cvxni7cd 95 9 including include VBG cord-280642-cvxni7cd 95 10 sickle sickle NN cord-280642-cvxni7cd 95 11 cell cell NN cord-280642-cvxni7cd 95 12 disease disease NN cord-280642-cvxni7cd 95 13 . . . cord-280642-cvxni7cd 96 1 Other other JJ cord-280642-cvxni7cd 96 2 immunosuppressive immunosuppressive JJ cord-280642-cvxni7cd 96 3 conditions condition NNS cord-280642-cvxni7cd 96 4 included include VBD cord-280642-cvxni7cd 96 5 HIV HIV NNP cord-280642-cvxni7cd 96 6 or or CC cord-280642-cvxni7cd 96 7 a a DT cord-280642-cvxni7cd 96 8 condition condition NN cord-280642-cvxni7cd 96 9 inducing induce VBG cord-280642-cvxni7cd 96 10 permanent permanent JJ cord-280642-cvxni7cd 96 11 immunodeficiency immunodeficiency NN cord-280642-cvxni7cd 96 12 ever ever RB cord-280642-cvxni7cd 96 13 diagnosed diagnose VBN cord-280642-cvxni7cd 96 14 , , , cord-280642-cvxni7cd 96 15 or or CC cord-280642-cvxni7cd 96 16 aplastic aplastic JJ cord-280642-cvxni7cd 96 17 anaemia anaemia NN cord-280642-cvxni7cd 96 18 or or CC cord-280642-cvxni7cd 96 19 temporary temporary JJ cord-280642-cvxni7cd 96 20 immunodeficiency immunodeficiency NN cord-280642-cvxni7cd 96 21 recorded record VBN cord-280642-cvxni7cd 96 22 within within IN cord-280642-cvxni7cd 96 23 the the DT cord-280642-cvxni7cd 96 24 last last JJ cord-280642-cvxni7cd 96 25 year year NN cord-280642-cvxni7cd 96 26 . . . cord-280642-cvxni7cd 97 1 Haematological Haematological NNP cord-280642-cvxni7cd 97 2 malignancies malignancy NNS cord-280642-cvxni7cd 97 3 were be VBD cord-280642-cvxni7cd 97 4 considered consider VBN cord-280642-cvxni7cd 97 5 separately separately RB cord-280642-cvxni7cd 97 6 from from IN cord-280642-cvxni7cd 97 7 other other JJ cord-280642-cvxni7cd 97 8 cancers cancer NNS cord-280642-cvxni7cd 97 9 to to TO cord-280642-cvxni7cd 97 10 reflect reflect VB cord-280642-cvxni7cd 97 11 the the DT cord-280642-cvxni7cd 97 12 immunosuppression immunosuppression NN cord-280642-cvxni7cd 97 13 associated associate VBN cord-280642-cvxni7cd 97 14 with with IN cord-280642-cvxni7cd 97 15 haematological haematological JJ cord-280642-cvxni7cd 97 16 malignancies malignancy NNS cord-280642-cvxni7cd 97 17 and and CC cord-280642-cvxni7cd 97 18 their -PRON- PRP$ cord-280642-cvxni7cd 97 19 treatment treatment NN cord-280642-cvxni7cd 97 20 . . . cord-280642-cvxni7cd 98 1 Kidney kidney NN cord-280642-cvxni7cd 98 2 function function NN cord-280642-cvxni7cd 98 3 was be VBD cord-280642-cvxni7cd 98 4 ascertained ascertain VBN cord-280642-cvxni7cd 98 5 from from IN cord-280642-cvxni7cd 98 6 the the DT cord-280642-cvxni7cd 98 7 most most RBS cord-280642-cvxni7cd 98 8 recent recent JJ cord-280642-cvxni7cd 98 9 serum serum NN cord-280642-cvxni7cd 98 10 creatinine creatinine NN cord-280642-cvxni7cd 98 11 measurement measurement NN cord-280642-cvxni7cd 98 12 , , , cord-280642-cvxni7cd 98 13 where where WRB cord-280642-cvxni7cd 98 14 available available JJ cord-280642-cvxni7cd 98 15 , , , cord-280642-cvxni7cd 98 16 converted convert VBN cord-280642-cvxni7cd 98 17 into into IN cord-280642-cvxni7cd 98 18 estimated estimated JJ cord-280642-cvxni7cd 98 19 glomerular glomerular JJ cord-280642-cvxni7cd 98 20 filtration filtration NN cord-280642-cvxni7cd 98 21 rate rate NN cord-280642-cvxni7cd 98 22 ( ( -LRB- cord-280642-cvxni7cd 98 23 eGFR egfr NN cord-280642-cvxni7cd 98 24 ) ) -RRB- cord-280642-cvxni7cd 98 25 using use VBG cord-280642-cvxni7cd 98 26 the the DT cord-280642-cvxni7cd 98 27 Chronic Chronic NNP cord-280642-cvxni7cd 98 28 Kidney Kidney NNP cord-280642-cvxni7cd 98 29 Disease Disease NNP cord-280642-cvxni7cd 98 30 Epidemiology Epidemiology NNP cord-280642-cvxni7cd 98 31 Collaboration Collaboration NNP cord-280642-cvxni7cd 98 32 ( ( -LRB- cord-280642-cvxni7cd 98 33 CKD CKD NNP cord-280642-cvxni7cd 98 34 - - HYPH cord-280642-cvxni7cd 98 35 EPI EPI NNP cord-280642-cvxni7cd 98 36 ) ) -RRB- cord-280642-cvxni7cd 98 37 equation equation NN cord-280642-cvxni7cd 98 38 , , , cord-280642-cvxni7cd 98 39 22 22 CD cord-280642-cvxni7cd 98 40 with with IN cord-280642-cvxni7cd 98 41 impaired impaired JJ cord-280642-cvxni7cd 98 42 kidney kidney NN cord-280642-cvxni7cd 98 43 function function NN cord-280642-cvxni7cd 98 44 defined define VBN cord-280642-cvxni7cd 98 45 as as IN cord-280642-cvxni7cd 98 46 eGFR egfr NN cord-280642-cvxni7cd 98 47 < < XX cord-280642-cvxni7cd 98 48 60 60 CD cord-280642-cvxni7cd 98 49 mL/ mL/ NNS cord-280642-cvxni7cd 99 1 min/1.73 min/1.73 NNP cord-280642-cvxni7cd 99 2 m m CD cord-280642-cvxni7cd 99 3 2 2 CD cord-280642-cvxni7cd 99 4 . . . cord-280642-cvxni7cd 100 1 Raised raise VBN cord-280642-cvxni7cd 100 2 blood blood NN cord-280642-cvxni7cd 100 3 pressure pressure NN cord-280642-cvxni7cd 100 4 ( ( -LRB- cord-280642-cvxni7cd 100 5 BP BP NNP cord-280642-cvxni7cd 100 6 ) ) -RRB- cord-280642-cvxni7cd 100 7 was be VBD cord-280642-cvxni7cd 100 8 defined define VBN cord-280642-cvxni7cd 100 9 as as IN cord-280642-cvxni7cd 100 10 either either CC cord-280642-cvxni7cd 100 11 a a DT cord-280642-cvxni7cd 100 12 prior prior JJ cord-280642-cvxni7cd 100 13 coded code VBN cord-280642-cvxni7cd 100 14 diagnosis diagnosis NN cord-280642-cvxni7cd 100 15 of of IN cord-280642-cvxni7cd 100 16 hypertension hypertension NN cord-280642-cvxni7cd 100 17 or or CC cord-280642-cvxni7cd 100 18 the the DT cord-280642-cvxni7cd 100 19 most most RBS cord-280642-cvxni7cd 100 20 recent recent JJ cord-280642-cvxni7cd 100 21 recording recording NN cord-280642-cvxni7cd 100 22 indicating indicate VBG cord-280642-cvxni7cd 100 23 systolic systolic JJ cord-280642-cvxni7cd 100 24 BP BP NNP cord-280642-cvxni7cd 100 25 ≥140 ≥140 NN cord-280642-cvxni7cd 100 26 mmHg mmHg NNS cord-280642-cvxni7cd 100 27 or or CC cord-280642-cvxni7cd 100 28 diastolic diastolic JJ cord-280642-cvxni7cd 100 29 BP BP NNP cord-280642-cvxni7cd 100 30 ≥90 ≥90 NNP cord-280642-cvxni7cd 100 31 mmHg mmHg NNP cord-280642-cvxni7cd 100 32 . . . cord-280642-cvxni7cd 101 1 Asthma asthma NN cord-280642-cvxni7cd 101 2 was be VBD cord-280642-cvxni7cd 101 3 grouped group VBN cord-280642-cvxni7cd 101 4 by by IN cord-280642-cvxni7cd 101 5 use use NN cord-280642-cvxni7cd 101 6 of of IN cord-280642-cvxni7cd 101 7 oral oral JJ cord-280642-cvxni7cd 101 8 corticosteroids corticosteroid NNS cord-280642-cvxni7cd 101 9 as as IN cord-280642-cvxni7cd 101 10 an an DT cord-280642-cvxni7cd 101 11 indication indication NN cord-280642-cvxni7cd 101 12 of of IN cord-280642-cvxni7cd 101 13 severity severity NN cord-280642-cvxni7cd 101 14 . . . cord-280642-cvxni7cd 102 1 Diabetes diabetes NN cord-280642-cvxni7cd 102 2 was be VBD cord-280642-cvxni7cd 102 3 grouped group VBN cord-280642-cvxni7cd 102 4 according accord VBG cord-280642-cvxni7cd 102 5 to to IN cord-280642-cvxni7cd 102 6 the the DT cord-280642-cvxni7cd 102 7 most most RBS cord-280642-cvxni7cd 102 8 recent recent JJ cord-280642-cvxni7cd 102 9 Hba1c hba1c IN cord-280642-cvxni7cd 102 10 measurement measurement NN cord-280642-cvxni7cd 102 11 , , , cord-280642-cvxni7cd 102 12 where where WRB cord-280642-cvxni7cd 102 13 a a DT cord-280642-cvxni7cd 102 14 measurement measurement NN cord-280642-cvxni7cd 102 15 was be VBD cord-280642-cvxni7cd 102 16 available available JJ cord-280642-cvxni7cd 102 17 within within IN cord-280642-cvxni7cd 102 18 the the DT cord-280642-cvxni7cd 102 19 last last JJ cord-280642-cvxni7cd 102 20 15 15 CD cord-280642-cvxni7cd 102 21 months month NNS cord-280642-cvxni7cd 102 22 , , , cord-280642-cvxni7cd 102 23 into into IN cord-280642-cvxni7cd 102 24 controlled control VBN cord-280642-cvxni7cd 102 25 ( ( -LRB- cord-280642-cvxni7cd 102 26 Hba1c hba1c IN cord-280642-cvxni7cd 102 27 < < XX cord-280642-cvxni7cd 102 28 58 58 CD cord-280642-cvxni7cd 102 29 mmols mmol NNS cord-280642-cvxni7cd 102 30 / / SYM cord-280642-cvxni7cd 102 31 mol mol NN cord-280642-cvxni7cd 102 32 ) ) -RRB- cord-280642-cvxni7cd 102 33 and and CC cord-280642-cvxni7cd 102 34 uncontrolled uncontrolled JJ cord-280642-cvxni7cd 102 35 ( ( -LRB- cord-280642-cvxni7cd 102 36 Hba1c hba1c IN cord-280642-cvxni7cd 102 37 > > XX cord-280642-cvxni7cd 102 38 = = SYM cord-280642-cvxni7cd 102 39 58 58 CD cord-280642-cvxni7cd 102 40 mmols mmol NNS cord-280642-cvxni7cd 102 41 / / SYM cord-280642-cvxni7cd 102 42 mol mol NN cord-280642-cvxni7cd 102 43 ) ) -RRB- cord-280642-cvxni7cd 102 44 . . . cord-280642-cvxni7cd 103 1 Cancer cancer NN cord-280642-cvxni7cd 103 2 was be VBD cord-280642-cvxni7cd 103 3 grouped group VBN cord-280642-cvxni7cd 103 4 by by IN cord-280642-cvxni7cd 103 5 time time NN cord-280642-cvxni7cd 103 6 since since IN cord-280642-cvxni7cd 103 7 the the DT cord-280642-cvxni7cd 103 8 first first JJ cord-280642-cvxni7cd 103 9 diagnosis diagnosis NN cord-280642-cvxni7cd 103 10 ( ( -LRB- cord-280642-cvxni7cd 103 11 within within IN cord-280642-cvxni7cd 103 12 the the DT cord-280642-cvxni7cd 103 13 last last JJ cord-280642-cvxni7cd 103 14 year year NN cord-280642-cvxni7cd 103 15 , , , cord-280642-cvxni7cd 103 16 2-<5 2-<5 NNP cord-280642-cvxni7cd 103 17 years year NNS cord-280642-cvxni7cd 103 18 , , , cord-280642-cvxni7cd 103 19 > > XX cord-280642-cvxni7cd 103 20 5 5 CD cord-280642-cvxni7cd 103 21 years year NNS cord-280642-cvxni7cd 103 22 ) ) -RRB- cord-280642-cvxni7cd 103 23 . . . cord-280642-cvxni7cd 104 1 Other other JJ cord-280642-cvxni7cd 104 2 covariates covariate NNS cord-280642-cvxni7cd 104 3 considered consider VBN cord-280642-cvxni7cd 104 4 as as IN cord-280642-cvxni7cd 104 5 potential potential JJ cord-280642-cvxni7cd 104 6 upstream upstream JJ cord-280642-cvxni7cd 104 7 risk risk NN cord-280642-cvxni7cd 104 8 factors factor NNS cord-280642-cvxni7cd 104 9 were be VBD cord-280642-cvxni7cd 104 10 deprivation deprivation NN cord-280642-cvxni7cd 104 11 and and CC cord-280642-cvxni7cd 104 12 ethnicity ethnicity NN cord-280642-cvxni7cd 104 13 . . . cord-280642-cvxni7cd 105 1 Deprivation deprivation NN cord-280642-cvxni7cd 105 2 was be VBD cord-280642-cvxni7cd 105 3 measured measure VBN cord-280642-cvxni7cd 105 4 by by IN cord-280642-cvxni7cd 105 5 the the DT cord-280642-cvxni7cd 105 6 Index Index NNP cord-280642-cvxni7cd 105 7 of of IN cord-280642-cvxni7cd 105 8 Multiple Multiple NNP cord-280642-cvxni7cd 105 9 Deprivation Deprivation NNP cord-280642-cvxni7cd 105 10 ( ( -LRB- cord-280642-cvxni7cd 105 11 IMD IMD NNP cord-280642-cvxni7cd 105 12 , , , cord-280642-cvxni7cd 105 13 in in IN cord-280642-cvxni7cd 105 14 quintiles quintile NNS cord-280642-cvxni7cd 105 15 , , , cord-280642-cvxni7cd 105 16 with with IN cord-280642-cvxni7cd 105 17 higher high JJR cord-280642-cvxni7cd 105 18 values value NNS cord-280642-cvxni7cd 105 19 indicating indicate VBG cord-280642-cvxni7cd 105 20 greater great JJR cord-280642-cvxni7cd 105 21 deprivation deprivation NN cord-280642-cvxni7cd 105 22 ) ) -RRB- cord-280642-cvxni7cd 105 23 , , , cord-280642-cvxni7cd 105 24 derived derive VBN cord-280642-cvxni7cd 105 25 from from IN cord-280642-cvxni7cd 105 26 the the DT cord-280642-cvxni7cd 105 27 patient patient NN cord-280642-cvxni7cd 105 28 's 's POS cord-280642-cvxni7cd 105 29 postcode postcode NN cord-280642-cvxni7cd 105 30 at at IN cord-280642-cvxni7cd 105 31 lower low JJR cord-280642-cvxni7cd 105 32 super super JJ cord-280642-cvxni7cd 105 33 output output NN cord-280642-cvxni7cd 105 34 area area NN cord-280642-cvxni7cd 105 35 level level NN cord-280642-cvxni7cd 105 36 for for IN cord-280642-cvxni7cd 105 37 a a DT cord-280642-cvxni7cd 105 38 high high JJ cord-280642-cvxni7cd 105 39 degree degree NN cord-280642-cvxni7cd 105 40 of of IN cord-280642-cvxni7cd 105 41 precision precision NN cord-280642-cvxni7cd 105 42 . . . cord-280642-cvxni7cd 106 1 Ethnicity ethnicity NN cord-280642-cvxni7cd 106 2 was be VBD cord-280642-cvxni7cd 106 3 grouped group VBN cord-280642-cvxni7cd 106 4 into into IN cord-280642-cvxni7cd 106 5 White White NNP cord-280642-cvxni7cd 106 6 , , , cord-280642-cvxni7cd 106 7 Black black JJ cord-280642-cvxni7cd 106 8 , , , cord-280642-cvxni7cd 106 9 Asian asian JJ cord-280642-cvxni7cd 106 10 or or CC cord-280642-cvxni7cd 106 11 Asian asian JJ cord-280642-cvxni7cd 106 12 British british JJ cord-280642-cvxni7cd 106 13 , , , cord-280642-cvxni7cd 106 14 Mixed mixed JJ cord-280642-cvxni7cd 106 15 , , , cord-280642-cvxni7cd 106 16 or or CC cord-280642-cvxni7cd 106 17 Other other JJ cord-280642-cvxni7cd 106 18 . . . cord-280642-cvxni7cd 107 1 The the DT cord-280642-cvxni7cd 107 2 Sustainability Sustainability NNP cord-280642-cvxni7cd 107 3 and and CC cord-280642-cvxni7cd 107 4 Transformation Transformation NNP cord-280642-cvxni7cd 107 5 Partnership Partnership NNP cord-280642-cvxni7cd 107 6 ( ( -LRB- cord-280642-cvxni7cd 107 7 STP STP NNP cord-280642-cvxni7cd 107 8 , , , cord-280642-cvxni7cd 107 9 an an DT cord-280642-cvxni7cd 107 10 NHS NHS NNP cord-280642-cvxni7cd 107 11 administrative administrative JJ cord-280642-cvxni7cd 107 12 region region NN cord-280642-cvxni7cd 107 13 ) ) -RRB- cord-280642-cvxni7cd 107 14 of of IN cord-280642-cvxni7cd 107 15 the the DT cord-280642-cvxni7cd 107 16 patient patient NN cord-280642-cvxni7cd 107 17 's 's POS cord-280642-cvxni7cd 107 18 general general JJ cord-280642-cvxni7cd 107 19 practice practice NN cord-280642-cvxni7cd 107 20 was be VBD cord-280642-cvxni7cd 107 21 included include VBN cord-280642-cvxni7cd 107 22 as as IN cord-280642-cvxni7cd 107 23 an an DT cord-280642-cvxni7cd 107 24 additional additional JJ cord-280642-cvxni7cd 107 25 adjustment adjustment NN cord-280642-cvxni7cd 107 26 for for IN cord-280642-cvxni7cd 107 27 geographical geographical JJ cord-280642-cvxni7cd 107 28 variation variation NN cord-280642-cvxni7cd 107 29 in in IN cord-280642-cvxni7cd 107 30 infection infection NN cord-280642-cvxni7cd 107 31 rates rate NNS cord-280642-cvxni7cd 107 32 across across IN cord-280642-cvxni7cd 107 33 the the DT cord-280642-cvxni7cd 107 34 country country NN cord-280642-cvxni7cd 107 35 . . . cord-280642-cvxni7cd 108 1 Information information NN cord-280642-cvxni7cd 108 2 on on IN cord-280642-cvxni7cd 108 3 all all DT cord-280642-cvxni7cd 108 4 covariates covariate NNS cord-280642-cvxni7cd 108 5 were be VBD cord-280642-cvxni7cd 108 6 obtained obtain VBN cord-280642-cvxni7cd 108 7 from from IN cord-280642-cvxni7cd 108 8 primary primary JJ cord-280642-cvxni7cd 108 9 care care NN cord-280642-cvxni7cd 108 10 records record NNS cord-280642-cvxni7cd 108 11 by by IN cord-280642-cvxni7cd 108 12 searching search VBG cord-280642-cvxni7cd 108 13 TPP TPP NNP cord-280642-cvxni7cd 108 14 SystmOne SystmOne NNP cord-280642-cvxni7cd 108 15 records record NNS cord-280642-cvxni7cd 108 16 for for IN cord-280642-cvxni7cd 108 17 specific specific JJ cord-280642-cvxni7cd 108 18 coded code VBN cord-280642-cvxni7cd 108 19 data datum NNS cord-280642-cvxni7cd 108 20 . . . cord-280642-cvxni7cd 109 1 TPP TPP NNP cord-280642-cvxni7cd 109 2 SystmOne SystmOne NNP cord-280642-cvxni7cd 109 3 allows allow VBZ cord-280642-cvxni7cd 109 4 users user NNS cord-280642-cvxni7cd 109 5 to to TO cord-280642-cvxni7cd 109 6 work work VB cord-280642-cvxni7cd 109 7 with with IN cord-280642-cvxni7cd 109 8 the the DT cord-280642-cvxni7cd 109 9 SNOMED SNOMED NNP cord-280642-cvxni7cd 109 10 - - HYPH cord-280642-cvxni7cd 109 11 CT CT NNP cord-280642-cvxni7cd 109 12 clinical clinical JJ cord-280642-cvxni7cd 109 13 terminology terminology NN cord-280642-cvxni7cd 109 14 , , , cord-280642-cvxni7cd 109 15 using use VBG cord-280642-cvxni7cd 109 16 a a DT cord-280642-cvxni7cd 109 17 GP GP NNP cord-280642-cvxni7cd 109 18 subset subset VBN cord-280642-cvxni7cd 109 19 of of IN cord-280642-cvxni7cd 109 20 SNOMED SNOMED NNP cord-280642-cvxni7cd 109 21 - - HYPH cord-280642-cvxni7cd 109 22 CT CT NNP cord-280642-cvxni7cd 109 23 codes code NNS cord-280642-cvxni7cd 109 24 . . . cord-280642-cvxni7cd 110 1 This this DT cord-280642-cvxni7cd 110 2 subset subset JJ cord-280642-cvxni7cd 110 3 maps map VBZ cord-280642-cvxni7cd 110 4 on on IN cord-280642-cvxni7cd 110 5 to to IN cord-280642-cvxni7cd 110 6 the the DT cord-280642-cvxni7cd 110 7 native native JJ cord-280642-cvxni7cd 110 8 Read Read NNP cord-280642-cvxni7cd 110 9 version version NN cord-280642-cvxni7cd 110 10 3 3 CD cord-280642-cvxni7cd 110 11 ( ( -LRB- cord-280642-cvxni7cd 110 12 CTV3 CTV3 NNP cord-280642-cvxni7cd 110 13 ) ) -RRB- cord-280642-cvxni7cd 110 14 clinical clinical JJ cord-280642-cvxni7cd 110 15 coding coding NN cord-280642-cvxni7cd 110 16 system system NN cord-280642-cvxni7cd 110 17 that that WDT cord-280642-cvxni7cd 110 18 SystmOne SystmOne NNP cord-280642-cvxni7cd 110 19 is be VBZ cord-280642-cvxni7cd 110 20 built build VBN cord-280642-cvxni7cd 110 21 on on IN cord-280642-cvxni7cd 110 22 . . . cord-280642-cvxni7cd 111 1 Medicines medicine NNS cord-280642-cvxni7cd 111 2 are be VBP cord-280642-cvxni7cd 111 3 entered enter VBN cord-280642-cvxni7cd 111 4 or or CC cord-280642-cvxni7cd 111 5 prescribed prescribe VBN cord-280642-cvxni7cd 111 6 in in IN cord-280642-cvxni7cd 111 7 a a DT cord-280642-cvxni7cd 111 8 format format NN cord-280642-cvxni7cd 111 9 compliant compliant JJ cord-280642-cvxni7cd 111 10 with with IN cord-280642-cvxni7cd 111 11 the the DT cord-280642-cvxni7cd 111 12 NHS NHS NNP cord-280642-cvxni7cd 111 13 Dictionary Dictionary NNP cord-280642-cvxni7cd 111 14 of of IN cord-280642-cvxni7cd 111 15 Medicines Medicines NNPS cord-280642-cvxni7cd 111 16 and and CC cord-280642-cvxni7cd 111 17 Devices Devices NNPS cord-280642-cvxni7cd 111 18 ( ( -LRB- cord-280642-cvxni7cd 111 19 dm+d dm+d NNP cord-280642-cvxni7cd 111 20 ) ) -RRB- cord-280642-cvxni7cd 111 21 , , , cord-280642-cvxni7cd 111 22 23 23 CD cord-280642-cvxni7cd 111 23 a a DT cord-280642-cvxni7cd 111 24 local local JJ cord-280642-cvxni7cd 111 25 UK UK NNP cord-280642-cvxni7cd 111 26 extension extension NN cord-280642-cvxni7cd 111 27 library library NN cord-280642-cvxni7cd 111 28 of of IN cord-280642-cvxni7cd 111 29 SNOMED SNOMED NNP cord-280642-cvxni7cd 111 30 . . . cord-280642-cvxni7cd 112 1 Code code NN cord-280642-cvxni7cd 112 2 lists list NNS cord-280642-cvxni7cd 112 3 for for IN cord-280642-cvxni7cd 112 4 particular particular JJ cord-280642-cvxni7cd 112 5 underlying underlying JJ cord-280642-cvxni7cd 112 6 conditions condition NNS cord-280642-cvxni7cd 112 7 and and CC cord-280642-cvxni7cd 112 8 medicines medicine NNS cord-280642-cvxni7cd 112 9 were be VBD cord-280642-cvxni7cd 112 10 compiled compile VBN cord-280642-cvxni7cd 112 11 from from IN cord-280642-cvxni7cd 112 12 a a DT cord-280642-cvxni7cd 112 13 variety variety NN cord-280642-cvxni7cd 112 14 of of IN cord-280642-cvxni7cd 112 15 sources source NNS cord-280642-cvxni7cd 112 16 . . . cord-280642-cvxni7cd 113 1 These these DT cord-280642-cvxni7cd 113 2 include include VBP cord-280642-cvxni7cd 113 3 BNF BNF NNP cord-280642-cvxni7cd 113 4 codes code NNS cord-280642-cvxni7cd 113 5 from from IN cord-280642-cvxni7cd 113 6 OpenPrescribing.net OpenPrescribing.net NNP cord-280642-cvxni7cd 113 7 , , , cord-280642-cvxni7cd 113 8 published publish VBN cord-280642-cvxni7cd 113 9 codelists codelist NNS cord-280642-cvxni7cd 113 10 for for IN cord-280642-cvxni7cd 113 11 asthma asthma NN cord-280642-cvxni7cd 113 12 , , , cord-280642-cvxni7cd 113 13 [ [ -LRB- cord-280642-cvxni7cd 113 14 24 24 CD cord-280642-cvxni7cd 113 15 ] ] -RRB- cord-280642-cvxni7cd 113 16 [ [ -LRB- cord-280642-cvxni7cd 113 17 25 25 CD cord-280642-cvxni7cd 113 18 ] ] -RRB- cord-280642-cvxni7cd 113 19 [ [ -LRB- cord-280642-cvxni7cd 113 20 26 26 CD cord-280642-cvxni7cd 113 21 ] ] -RRB- cord-280642-cvxni7cd 113 22 immunosuppression immunosuppression NN cord-280642-cvxni7cd 113 23 , , , cord-280642-cvxni7cd 113 24 [ [ -LRB- cord-280642-cvxni7cd 113 25 27 27 CD cord-280642-cvxni7cd 113 26 ] ] -RRB- cord-280642-cvxni7cd 113 27 [ [ -LRB- cord-280642-cvxni7cd 113 28 28 28 CD cord-280642-cvxni7cd 113 29 ] ] -RRB- cord-280642-cvxni7cd 113 30 [ [ -LRB- cord-280642-cvxni7cd 113 31 29 29 CD cord-280642-cvxni7cd 113 32 ] ] -RRB- cord-280642-cvxni7cd 113 33 psoriasis psoriasis NN cord-280642-cvxni7cd 113 34 , , , cord-280642-cvxni7cd 113 35 30 30 CD cord-280642-cvxni7cd 113 36 . . . cord-280642-cvxni7cd 114 1 CC CC NNP cord-280642-cvxni7cd 114 2 - - : cord-280642-cvxni7cd 114 3 BY by IN cord-280642-cvxni7cd 114 4 4.0 4.0 CD cord-280642-cvxni7cd 114 5 International international JJ cord-280642-cvxni7cd 114 6 license license NN cord-280642-cvxni7cd 115 1 It -PRON- PRP cord-280642-cvxni7cd 115 2 is be VBZ cord-280642-cvxni7cd 115 3 made make VBN cord-280642-cvxni7cd 115 4 available available JJ cord-280642-cvxni7cd 115 5 under under IN cord-280642-cvxni7cd 115 6 a a DT cord-280642-cvxni7cd 116 1 is be VBZ cord-280642-cvxni7cd 116 2 the the DT cord-280642-cvxni7cd 116 3 author author NN cord-280642-cvxni7cd 116 4 / / SYM cord-280642-cvxni7cd 116 5 funder funder NN cord-280642-cvxni7cd 116 6 , , , cord-280642-cvxni7cd 116 7 who who WP cord-280642-cvxni7cd 116 8 has have VBZ cord-280642-cvxni7cd 116 9 granted grant VBN cord-280642-cvxni7cd 116 10 medRxiv medRxiv NNS cord-280642-cvxni7cd 116 11 a a DT cord-280642-cvxni7cd 116 12 license license NN cord-280642-cvxni7cd 116 13 to to TO cord-280642-cvxni7cd 116 14 display display VB cord-280642-cvxni7cd 116 15 the the DT cord-280642-cvxni7cd 116 16 preprint preprint NN cord-280642-cvxni7cd 116 17 in in IN cord-280642-cvxni7cd 116 18 perpetuity perpetuity NN cord-280642-cvxni7cd 116 19 . . . cord-280642-cvxni7cd 117 1 The the DT cord-280642-cvxni7cd 117 2 copyright copyright NN cord-280642-cvxni7cd 117 3 holder holder NN cord-280642-cvxni7cd 117 4 for for IN cord-280642-cvxni7cd 117 5 this this DT cord-280642-cvxni7cd 117 6 preprint preprint NN cord-280642-cvxni7cd 117 7 this this DT cord-280642-cvxni7cd 117 8 version version NN cord-280642-cvxni7cd 117 9 posted post VBN cord-280642-cvxni7cd 117 10 May May NNP cord-280642-cvxni7cd 117 11 7 7 CD cord-280642-cvxni7cd 117 12 , , , cord-280642-cvxni7cd 117 13 2020 2020 CD cord-280642-cvxni7cd 117 14 . . . cord-280642-cvxni7cd 117 15 . . . cord-280642-cvxni7cd 118 1 https://doi.org/10.1101/2020.05.06.20092999 https://doi.org/10.1101/2020.05.06.20092999 NNP cord-280642-cvxni7cd 118 2 doi doi NNP cord-280642-cvxni7cd 118 3 : : : cord-280642-cvxni7cd 119 1 medRxiv medRxiv NNP cord-280642-cvxni7cd 119 2 preprint preprint NN cord-280642-cvxni7cd 119 3 SLE SLE NNP cord-280642-cvxni7cd 119 4 , , , cord-280642-cvxni7cd 119 5 31 31 CD cord-280642-cvxni7cd 119 6 RA RA NNP cord-280642-cvxni7cd 119 7 32 32 CD cord-280642-cvxni7cd 119 8 , , , cord-280642-cvxni7cd 119 9 33 33 CD cord-280642-cvxni7cd 119 10 and and CC cord-280642-cvxni7cd 119 11 cancer cancer NN cord-280642-cvxni7cd 119 12 , , , cord-280642-cvxni7cd 119 13 34 34 CD cord-280642-cvxni7cd 119 14 , , , cord-280642-cvxni7cd 119 15 35 35 CD cord-280642-cvxni7cd 119 16 and and CC cord-280642-cvxni7cd 119 17 Read read VB cord-280642-cvxni7cd 119 18 Code Code NNP cord-280642-cvxni7cd 119 19 2 2 CD cord-280642-cvxni7cd 119 20 lists list NNS cord-280642-cvxni7cd 119 21 designed design VBN cord-280642-cvxni7cd 119 22 specifically specifically RB cord-280642-cvxni7cd 119 23 to to TO cord-280642-cvxni7cd 119 24 describe describe VB cord-280642-cvxni7cd 119 25 groups group NNS cord-280642-cvxni7cd 119 26 at at IN cord-280642-cvxni7cd 119 27 increased increase VBN cord-280642-cvxni7cd 119 28 risk risk NN cord-280642-cvxni7cd 119 29 of of IN cord-280642-cvxni7cd 119 30 influenza influenza NN cord-280642-cvxni7cd 119 31 infection infection NN cord-280642-cvxni7cd 119 32 . . . cord-280642-cvxni7cd 120 1 36 36 CD cord-280642-cvxni7cd 121 1 Read read VB cord-280642-cvxni7cd 121 2 Code Code NNP cord-280642-cvxni7cd 121 3 2 2 CD cord-280642-cvxni7cd 121 4 lists list NNS cord-280642-cvxni7cd 121 5 were be VBD cord-280642-cvxni7cd 121 6 added add VBN cord-280642-cvxni7cd 121 7 to to IN cord-280642-cvxni7cd 121 8 with with IN cord-280642-cvxni7cd 121 9 SNOMED SNOMED NNP cord-280642-cvxni7cd 121 10 codes code NNS cord-280642-cvxni7cd 121 11 and and CC cord-280642-cvxni7cd 121 12 cross cross NN cord-280642-cvxni7cd 121 13 - - VBN cord-280642-cvxni7cd 121 14 checked check VBN cord-280642-cvxni7cd 121 15 against against IN cord-280642-cvxni7cd 121 16 NHS NHS NNP cord-280642-cvxni7cd 121 17 QOF QOF NNP cord-280642-cvxni7cd 121 18 registers register NNS cord-280642-cvxni7cd 121 19 , , , cord-280642-cvxni7cd 121 20 then then RB cord-280642-cvxni7cd 121 21 translated translate VBD cord-280642-cvxni7cd 121 22 into into IN cord-280642-cvxni7cd 121 23 CTV3 CTV3 NNP cord-280642-cvxni7cd 121 24 with with IN cord-280642-cvxni7cd 121 25 manual manual JJ cord-280642-cvxni7cd 121 26 curation curation NN cord-280642-cvxni7cd 121 27 . . . cord-280642-cvxni7cd 122 1 Decisions decision NNS cord-280642-cvxni7cd 122 2 on on IN cord-280642-cvxni7cd 122 3 every every DT cord-280642-cvxni7cd 122 4 code code NN cord-280642-cvxni7cd 122 5 list list NN cord-280642-cvxni7cd 122 6 were be VBD cord-280642-cvxni7cd 122 7 documented document VBN cord-280642-cvxni7cd 122 8 and and CC cord-280642-cvxni7cd 122 9 final final JJ cord-280642-cvxni7cd 122 10 lists list NNS cord-280642-cvxni7cd 122 11 reviewed review VBN cord-280642-cvxni7cd 122 12 by by IN cord-280642-cvxni7cd 122 13 at at RB cord-280642-cvxni7cd 122 14 least least RBS cord-280642-cvxni7cd 122 15 two two CD cord-280642-cvxni7cd 122 16 authors author NNS cord-280642-cvxni7cd 122 17 . . . cord-280642-cvxni7cd 123 1 Detailed detailed JJ cord-280642-cvxni7cd 123 2 information information NN cord-280642-cvxni7cd 123 3 on on IN cord-280642-cvxni7cd 123 4 compilation compilation NN cord-280642-cvxni7cd 123 5 and and CC cord-280642-cvxni7cd 123 6 sources source NNS cord-280642-cvxni7cd 123 7 for for IN cord-280642-cvxni7cd 123 8 every every DT cord-280642-cvxni7cd 123 9 individual individual JJ cord-280642-cvxni7cd 123 10 codelist codelist NN cord-280642-cvxni7cd 123 11 is be VBZ cord-280642-cvxni7cd 123 12 available available JJ cord-280642-cvxni7cd 123 13 at at IN cord-280642-cvxni7cd 123 14 https://codelists.opensafely.org/ https://codelists.opensafely.org/ ADD cord-280642-cvxni7cd 123 15 and and CC cord-280642-cvxni7cd 123 16 the the DT cord-280642-cvxni7cd 123 17 lists list NNS cord-280642-cvxni7cd 123 18 are be VBP cord-280642-cvxni7cd 123 19 available available JJ cord-280642-cvxni7cd 123 20 for for IN cord-280642-cvxni7cd 123 21 inspection inspection NN cord-280642-cvxni7cd 123 22 and and CC cord-280642-cvxni7cd 123 23 re re NN cord-280642-cvxni7cd 123 24 - - NN cord-280642-cvxni7cd 123 25 use use NN cord-280642-cvxni7cd 123 26 by by IN cord-280642-cvxni7cd 123 27 the the DT cord-280642-cvxni7cd 123 28 broader broad JJR cord-280642-cvxni7cd 123 29 research research NN cord-280642-cvxni7cd 123 30 community community NN cord-280642-cvxni7cd 123 31 . . . cord-280642-cvxni7cd 124 1 37 37 CD cord-280642-cvxni7cd 124 2 Statistical Statistical NNP cord-280642-cvxni7cd 124 3 Analysis Analysis NNP cord-280642-cvxni7cd 124 4 Patient Patient NNP cord-280642-cvxni7cd 124 5 numbers number NNS cord-280642-cvxni7cd 124 6 are be VBP cord-280642-cvxni7cd 124 7 depicted depict VBN cord-280642-cvxni7cd 124 8 in in IN cord-280642-cvxni7cd 124 9 figure figure NN cord-280642-cvxni7cd 124 10 1 1 CD cord-280642-cvxni7cd 124 11 . . . cord-280642-cvxni7cd 125 1 The the DT cord-280642-cvxni7cd 125 2 Kaplan Kaplan NNP cord-280642-cvxni7cd 125 3 - - HYPH cord-280642-cvxni7cd 125 4 Meier Meier NNP cord-280642-cvxni7cd 125 5 failure failure NN cord-280642-cvxni7cd 125 6 function function NN cord-280642-cvxni7cd 125 7 by by IN cord-280642-cvxni7cd 125 8 age age NN cord-280642-cvxni7cd 125 9 group group NN cord-280642-cvxni7cd 125 10 and and CC cord-280642-cvxni7cd 125 11 sex sex NN cord-280642-cvxni7cd 125 12 are be VBP cord-280642-cvxni7cd 125 13 shown show VBN cord-280642-cvxni7cd 125 14 in in IN cord-280642-cvxni7cd 125 15 figure figure NN cord-280642-cvxni7cd 125 16 2 2 CD cord-280642-cvxni7cd 125 17 . . . cord-280642-cvxni7cd 126 1 For for IN cord-280642-cvxni7cd 126 2 each each DT cord-280642-cvxni7cd 126 3 potential potential JJ cord-280642-cvxni7cd 126 4 risk risk NN cord-280642-cvxni7cd 126 5 factor factor NN cord-280642-cvxni7cd 126 6 , , , cord-280642-cvxni7cd 126 7 a a DT cord-280642-cvxni7cd 126 8 Cox Cox NNP cord-280642-cvxni7cd 126 9 proportional proportional JJ cord-280642-cvxni7cd 126 10 hazards hazard NNS cord-280642-cvxni7cd 126 11 model model NN cord-280642-cvxni7cd 126 12 was be VBD cord-280642-cvxni7cd 126 13 fitted fit VBN cord-280642-cvxni7cd 126 14 , , , cord-280642-cvxni7cd 126 15 with with IN cord-280642-cvxni7cd 126 16 days day NNS cord-280642-cvxni7cd 126 17 in in IN cord-280642-cvxni7cd 126 18 study study NN cord-280642-cvxni7cd 126 19 as as IN cord-280642-cvxni7cd 126 20 the the DT cord-280642-cvxni7cd 126 21 timescale timescale NN cord-280642-cvxni7cd 126 22 , , , cord-280642-cvxni7cd 126 23 stratified stratify VBN cord-280642-cvxni7cd 126 24 by by IN cord-280642-cvxni7cd 126 25 geographic geographic JJ cord-280642-cvxni7cd 126 26 area area NN cord-280642-cvxni7cd 126 27 ( ( -LRB- cord-280642-cvxni7cd 126 28 STP STP NNP cord-280642-cvxni7cd 126 29 ) ) -RRB- cord-280642-cvxni7cd 126 30 , , , cord-280642-cvxni7cd 126 31 and and CC cord-280642-cvxni7cd 126 32 adjusted adjust VBN cord-280642-cvxni7cd 126 33 for for IN cord-280642-cvxni7cd 126 34 sex sex NN cord-280642-cvxni7cd 126 35 and and CC cord-280642-cvxni7cd 126 36 age age NN cord-280642-cvxni7cd 126 37 modelled model VBN cord-280642-cvxni7cd 126 38 using use VBG cord-280642-cvxni7cd 126 39 restricted restricted JJ cord-280642-cvxni7cd 126 40 cubic cubic JJ cord-280642-cvxni7cd 126 41 splines spline NNS cord-280642-cvxni7cd 126 42 . . . cord-280642-cvxni7cd 127 1 Violations violation NNS cord-280642-cvxni7cd 127 2 of of IN cord-280642-cvxni7cd 127 3 the the DT cord-280642-cvxni7cd 127 4 proportional proportional JJ cord-280642-cvxni7cd 127 5 hazards hazard NNS cord-280642-cvxni7cd 127 6 assumption assumption NN cord-280642-cvxni7cd 127 7 were be VBD cord-280642-cvxni7cd 127 8 explored explore VBN cord-280642-cvxni7cd 127 9 by by IN cord-280642-cvxni7cd 127 10 testing test VBG cord-280642-cvxni7cd 127 11 for for IN cord-280642-cvxni7cd 127 12 a a DT cord-280642-cvxni7cd 127 13 zero zero CD cord-280642-cvxni7cd 127 14 slope slope NN cord-280642-cvxni7cd 127 15 in in IN cord-280642-cvxni7cd 127 16 the the DT cord-280642-cvxni7cd 127 17 scaled scale VBN cord-280642-cvxni7cd 127 18 Schoenfeld Schoenfeld NNP cord-280642-cvxni7cd 127 19 residuals residual NNS cord-280642-cvxni7cd 127 20 . . . cord-280642-cvxni7cd 128 1 All all DT cord-280642-cvxni7cd 128 2 potential potential JJ cord-280642-cvxni7cd 128 3 risk risk NN cord-280642-cvxni7cd 128 4 factors factor NNS cord-280642-cvxni7cd 128 5 , , , cord-280642-cvxni7cd 128 6 including include VBG cord-280642-cvxni7cd 128 7 age age NN cord-280642-cvxni7cd 128 8 ( ( -LRB- cord-280642-cvxni7cd 128 9 again again RB cord-280642-cvxni7cd 128 10 modelled model VBN cord-280642-cvxni7cd 128 11 as as IN cord-280642-cvxni7cd 128 12 a a DT cord-280642-cvxni7cd 128 13 spline spline NN cord-280642-cvxni7cd 128 14 ) ) -RRB- cord-280642-cvxni7cd 128 15 , , , cord-280642-cvxni7cd 128 16 sex sex NN cord-280642-cvxni7cd 128 17 , , , cord-280642-cvxni7cd 128 18 BMI BMI NNP cord-280642-cvxni7cd 128 19 , , , cord-280642-cvxni7cd 128 20 smoking smoking NN cord-280642-cvxni7cd 128 21 , , , cord-280642-cvxni7cd 128 22 index index NN cord-280642-cvxni7cd 128 23 of of IN cord-280642-cvxni7cd 128 24 multiple multiple JJ cord-280642-cvxni7cd 128 25 deprivation deprivation NN cord-280642-cvxni7cd 128 26 quintile quintile NN cord-280642-cvxni7cd 128 27 , , , cord-280642-cvxni7cd 128 28 and and CC cord-280642-cvxni7cd 128 29 comorbidities comorbiditie NNS cord-280642-cvxni7cd 128 30 listed list VBN cord-280642-cvxni7cd 128 31 above above RB cord-280642-cvxni7cd 128 32 were be VBD cord-280642-cvxni7cd 128 33 then then RB cord-280642-cvxni7cd 128 34 included include VBN cord-280642-cvxni7cd 128 35 in in IN cord-280642-cvxni7cd 128 36 a a DT cord-280642-cvxni7cd 128 37 single single JJ cord-280642-cvxni7cd 128 38 multivariable multivariable JJ cord-280642-cvxni7cd 128 39 Cox Cox NNP cord-280642-cvxni7cd 128 40 proportional proportional JJ cord-280642-cvxni7cd 128 41 hazards hazard NNS cord-280642-cvxni7cd 128 42 model model NN cord-280642-cvxni7cd 128 43 , , , cord-280642-cvxni7cd 128 44 stratified stratify VBN cord-280642-cvxni7cd 128 45 by by IN cord-280642-cvxni7cd 128 46 STP STP NNP cord-280642-cvxni7cd 128 47 . . . cord-280642-cvxni7cd 129 1 Hazard hazard NN cord-280642-cvxni7cd 129 2 ratios ratio NNS cord-280642-cvxni7cd 129 3 from from IN cord-280642-cvxni7cd 129 4 the the DT cord-280642-cvxni7cd 129 5 age age NN cord-280642-cvxni7cd 129 6 / / SYM cord-280642-cvxni7cd 129 7 sex sex NN cord-280642-cvxni7cd 129 8 adjusted adjust VBD cord-280642-cvxni7cd 129 9 and and CC cord-280642-cvxni7cd 129 10 fully fully RB cord-280642-cvxni7cd 129 11 adjusted adjust VBN cord-280642-cvxni7cd 129 12 models model NNS cord-280642-cvxni7cd 129 13 are be VBP cord-280642-cvxni7cd 129 14 reported report VBN cord-280642-cvxni7cd 129 15 with with IN cord-280642-cvxni7cd 129 16 95 95 CD cord-280642-cvxni7cd 129 17 % % NN cord-280642-cvxni7cd 129 18 confidence confidence NN cord-280642-cvxni7cd 129 19 intervals interval NNS cord-280642-cvxni7cd 129 20 . . . cord-280642-cvxni7cd 130 1 Models model NNS cord-280642-cvxni7cd 130 2 were be VBD cord-280642-cvxni7cd 130 3 also also RB cord-280642-cvxni7cd 130 4 refitted refit VBN cord-280642-cvxni7cd 130 5 with with IN cord-280642-cvxni7cd 130 6 age age NN cord-280642-cvxni7cd 130 7 group group NN cord-280642-cvxni7cd 130 8 fitted fit VBN cord-280642-cvxni7cd 130 9 as as IN cord-280642-cvxni7cd 130 10 a a DT cord-280642-cvxni7cd 130 11 categorical categorical JJ cord-280642-cvxni7cd 130 12 variable variable NN cord-280642-cvxni7cd 130 13 in in IN cord-280642-cvxni7cd 130 14 order order NN cord-280642-cvxni7cd 130 15 to to TO cord-280642-cvxni7cd 130 16 obtain obtain VB cord-280642-cvxni7cd 130 17 hazard hazard NN cord-280642-cvxni7cd 130 18 ratios ratio NNS cord-280642-cvxni7cd 130 19 by by IN cord-280642-cvxni7cd 130 20 age age NN cord-280642-cvxni7cd 130 21 group group NN cord-280642-cvxni7cd 130 22 . . . cord-280642-cvxni7cd 131 1 In in IN cord-280642-cvxni7cd 131 2 the the DT cord-280642-cvxni7cd 131 3 primary primary JJ cord-280642-cvxni7cd 131 4 analysis analysis NN cord-280642-cvxni7cd 131 5 , , , cord-280642-cvxni7cd 131 6 those those DT cord-280642-cvxni7cd 131 7 with with IN cord-280642-cvxni7cd 131 8 missing miss VBG cord-280642-cvxni7cd 131 9 BMI BMI NNP cord-280642-cvxni7cd 131 10 were be VBD cord-280642-cvxni7cd 131 11 assumed assume VBN cord-280642-cvxni7cd 131 12 non non JJ cord-280642-cvxni7cd 131 13 - - JJ cord-280642-cvxni7cd 131 14 obese obese JJ cord-280642-cvxni7cd 131 15 and and CC cord-280642-cvxni7cd 131 16 those those DT cord-280642-cvxni7cd 131 17 with with IN cord-280642-cvxni7cd 131 18 missing miss VBG cord-280642-cvxni7cd 131 19 smoking smoking NN cord-280642-cvxni7cd 131 20 information information NN cord-280642-cvxni7cd 131 21 were be VBD cord-280642-cvxni7cd 131 22 assumed assume VBN cord-280642-cvxni7cd 131 23 to to TO cord-280642-cvxni7cd 131 24 be be VB cord-280642-cvxni7cd 131 25 nonsmokers nonsmoker NNS cord-280642-cvxni7cd 131 26 on on IN cord-280642-cvxni7cd 131 27 the the DT cord-280642-cvxni7cd 131 28 assumption assumption NN cord-280642-cvxni7cd 131 29 that that IN cord-280642-cvxni7cd 131 30 both both CC cord-280642-cvxni7cd 131 31 obesity obesity NN cord-280642-cvxni7cd 131 32 and and CC cord-280642-cvxni7cd 131 33 smoking smoking NN cord-280642-cvxni7cd 131 34 would would MD cord-280642-cvxni7cd 131 35 be be VB cord-280642-cvxni7cd 131 36 likely likely JJ cord-280642-cvxni7cd 131 37 to to TO cord-280642-cvxni7cd 131 38 be be VB cord-280642-cvxni7cd 131 39 recorded record VBN cord-280642-cvxni7cd 131 40 if if IN cord-280642-cvxni7cd 131 41 present present JJ cord-280642-cvxni7cd 131 42 . . . cord-280642-cvxni7cd 132 1 A a DT cord-280642-cvxni7cd 132 2 sensitivity sensitivity NN cord-280642-cvxni7cd 132 3 analysis analysis NN cord-280642-cvxni7cd 132 4 was be VBD cord-280642-cvxni7cd 132 5 run run VBN cord-280642-cvxni7cd 132 6 among among IN cord-280642-cvxni7cd 132 7 those those DT cord-280642-cvxni7cd 132 8 with with IN cord-280642-cvxni7cd 132 9 complete complete JJ cord-280642-cvxni7cd 132 10 BMI bmi NN cord-280642-cvxni7cd 132 11 and and CC cord-280642-cvxni7cd 132 12 smoking smoking NN cord-280642-cvxni7cd 132 13 data datum NNS cord-280642-cvxni7cd 132 14 only only RB cord-280642-cvxni7cd 132 15 . . . cord-280642-cvxni7cd 133 1 Ethnicity ethnicity NN cord-280642-cvxni7cd 133 2 was be VBD cord-280642-cvxni7cd 133 3 omitted omit VBN cord-280642-cvxni7cd 133 4 from from IN cord-280642-cvxni7cd 133 5 the the DT cord-280642-cvxni7cd 133 6 main main JJ cord-280642-cvxni7cd 133 7 multivariable multivariable JJ cord-280642-cvxni7cd 133 8 model model NN cord-280642-cvxni7cd 133 9 due due IN cord-280642-cvxni7cd 133 10 to to IN cord-280642-cvxni7cd 133 11 26 26 CD cord-280642-cvxni7cd 133 12 % % NN cord-280642-cvxni7cd 133 13 of of IN cord-280642-cvxni7cd 133 14 individuals individual NNS cord-280642-cvxni7cd 133 15 having have VBG cord-280642-cvxni7cd 133 16 missing miss VBG cord-280642-cvxni7cd 133 17 data datum NNS cord-280642-cvxni7cd 133 18 ; ; : cord-280642-cvxni7cd 133 19 hazard hazard NN cord-280642-cvxni7cd 133 20 ratios ratio NNS cord-280642-cvxni7cd 133 21 for for IN cord-280642-cvxni7cd 133 22 ethnicity ethnicity NN cord-280642-cvxni7cd 133 23 were be VBD cord-280642-cvxni7cd 133 24 therefore therefore RB cord-280642-cvxni7cd 133 25 obtained obtain VBN cord-280642-cvxni7cd 133 26 from from IN cord-280642-cvxni7cd 133 27 a a DT cord-280642-cvxni7cd 133 28 separate separate JJ cord-280642-cvxni7cd 133 29 model model NN cord-280642-cvxni7cd 133 30 among among IN cord-280642-cvxni7cd 133 31 individuals individual NNS cord-280642-cvxni7cd 133 32 with with IN cord-280642-cvxni7cd 133 33 complete complete JJ cord-280642-cvxni7cd 133 34 ethnicity ethnicity NN cord-280642-cvxni7cd 133 35 only only RB cord-280642-cvxni7cd 133 36 . . . cord-280642-cvxni7cd 134 1 Hazard hazard NN cord-280642-cvxni7cd 134 2 ratios ratio NNS cord-280642-cvxni7cd 134 3 for for IN cord-280642-cvxni7cd 134 4 other other JJ cord-280642-cvxni7cd 134 5 risk risk NN cord-280642-cvxni7cd 134 6 factors factor NNS cord-280642-cvxni7cd 134 7 , , , cord-280642-cvxni7cd 134 8 adjusted adjust VBN cord-280642-cvxni7cd 134 9 for for IN cord-280642-cvxni7cd 134 10 ethnicity ethnicity NN cord-280642-cvxni7cd 134 11 , , , cord-280642-cvxni7cd 134 12 were be VBD cord-280642-cvxni7cd 134 13 also also RB cord-280642-cvxni7cd 134 14 obtained obtain VBN cord-280642-cvxni7cd 134 15 from from IN cord-280642-cvxni7cd 134 16 this this DT cord-280642-cvxni7cd 134 17 model model NN cord-280642-cvxni7cd 134 18 and and CC cord-280642-cvxni7cd 134 19 are be VBP cord-280642-cvxni7cd 134 20 presented present VBN cord-280642-cvxni7cd 134 21 in in IN cord-280642-cvxni7cd 134 22 the the DT cord-280642-cvxni7cd 134 23 sensitivity sensitivity NN cord-280642-cvxni7cd 134 24 analyses analysis NNS cord-280642-cvxni7cd 134 25 to to TO cord-280642-cvxni7cd 134 26 allow allow VB cord-280642-cvxni7cd 134 27 assessment assessment NN cord-280642-cvxni7cd 134 28 of of IN cord-280642-cvxni7cd 134 29 the the DT cord-280642-cvxni7cd 134 30 potential potential NN cord-280642-cvxni7cd 134 31 for for IN cord-280642-cvxni7cd 134 32 confounding confound VBG cord-280642-cvxni7cd 134 33 by by IN cord-280642-cvxni7cd 134 34 ethnicity ethnicity NN cord-280642-cvxni7cd 134 35 in in IN cord-280642-cvxni7cd 134 36 the the DT cord-280642-cvxni7cd 134 37 primary primary JJ cord-280642-cvxni7cd 134 38 model model NN cord-280642-cvxni7cd 134 39 . . . cord-280642-cvxni7cd 135 1 All all DT cord-280642-cvxni7cd 135 2 multivariable multivariable JJ cord-280642-cvxni7cd 135 3 models model NNS cord-280642-cvxni7cd 135 4 excluded exclude VBD cord-280642-cvxni7cd 135 5 the the DT cord-280642-cvxni7cd 135 6 very very RB cord-280642-cvxni7cd 135 7 small small JJ cord-280642-cvxni7cd 135 8 number number NN cord-280642-cvxni7cd 135 9 of of IN cord-280642-cvxni7cd 135 10 patients patient NNS cord-280642-cvxni7cd 135 11 ( ( -LRB- cord-280642-cvxni7cd 135 12 < < NNP cord-280642-cvxni7cd 135 13 1 1 CD cord-280642-cvxni7cd 135 14 % % NN cord-280642-cvxni7cd 135 15 ) ) -RRB- cord-280642-cvxni7cd 135 16 with with IN cord-280642-cvxni7cd 135 17 missing miss VBG cord-280642-cvxni7cd 135 18 IMD IMD NNP cord-280642-cvxni7cd 135 19 . . . cord-280642-cvxni7cd 136 1 The the DT cord-280642-cvxni7cd 136 2 C c NN cord-280642-cvxni7cd 136 3 - - HYPH cord-280642-cvxni7cd 136 4 statistic statistic NN cord-280642-cvxni7cd 136 5 was be VBD cord-280642-cvxni7cd 136 6 calculated calculate VBN cord-280642-cvxni7cd 136 7 as as IN cord-280642-cvxni7cd 136 8 a a DT cord-280642-cvxni7cd 136 9 measure measure NN cord-280642-cvxni7cd 136 10 of of IN cord-280642-cvxni7cd 136 11 model model NN cord-280642-cvxni7cd 136 12 discrimination discrimination NN cord-280642-cvxni7cd 136 13 . . . cord-280642-cvxni7cd 137 1 Due due IN cord-280642-cvxni7cd 137 2 to to IN cord-280642-cvxni7cd 137 3 computational computational JJ cord-280642-cvxni7cd 137 4 time time NN cord-280642-cvxni7cd 137 5 , , , cord-280642-cvxni7cd 137 6 this this DT cord-280642-cvxni7cd 137 7 was be VBD cord-280642-cvxni7cd 137 8 estimated estimate VBN cord-280642-cvxni7cd 137 9 by by IN cord-280642-cvxni7cd 137 10 randomly randomly RB cord-280642-cvxni7cd 137 11 sampling sample VBG cord-280642-cvxni7cd 137 12 5000 5000 CD cord-280642-cvxni7cd 137 13 patients patient NNS cord-280642-cvxni7cd 137 14 without without IN cord-280642-cvxni7cd 137 15 the the DT cord-280642-cvxni7cd 137 16 outcome outcome NN cord-280642-cvxni7cd 137 17 and and CC cord-280642-cvxni7cd 137 18 calculating calculate VBG cord-280642-cvxni7cd 137 19 the the DT cord-280642-cvxni7cd 137 20 C c NN cord-280642-cvxni7cd 137 21 - - HYPH cord-280642-cvxni7cd 137 22 statistic statistic NN cord-280642-cvxni7cd 137 23 using use VBG cord-280642-cvxni7cd 137 24 the the DT cord-280642-cvxni7cd 137 25 random random JJ cord-280642-cvxni7cd 137 26 sample sample NN cord-280642-cvxni7cd 137 27 and and CC cord-280642-cvxni7cd 137 28 all all DT cord-280642-cvxni7cd 137 29 patients patient NNS cord-280642-cvxni7cd 137 30 who who WP cord-280642-cvxni7cd 137 31 experienced experience VBD cord-280642-cvxni7cd 137 32 the the DT cord-280642-cvxni7cd 137 33 outcome outcome NN cord-280642-cvxni7cd 137 34 , , , cord-280642-cvxni7cd 137 35 repeating repeat VBG cord-280642-cvxni7cd 137 36 this this DT cord-280642-cvxni7cd 137 37 10 10 CD cord-280642-cvxni7cd 137 38 times time NNS cord-280642-cvxni7cd 137 39 and and CC cord-280642-cvxni7cd 137 40 taking take VBG cord-280642-cvxni7cd 137 41 the the DT cord-280642-cvxni7cd 137 42 average average JJ cord-280642-cvxni7cd 137 43 Cstatistic Cstatistic NNP cord-280642-cvxni7cd 137 44 . . . cord-280642-cvxni7cd 138 1 NHS NHS NNP cord-280642-cvxni7cd 138 2 England England NNP cord-280642-cvxni7cd 138 3 is be VBZ cord-280642-cvxni7cd 138 4 the the DT cord-280642-cvxni7cd 138 5 data data NN cord-280642-cvxni7cd 138 6 controller controller NN cord-280642-cvxni7cd 138 7 ; ; : cord-280642-cvxni7cd 138 8 TPP TPP NNP cord-280642-cvxni7cd 138 9 is be VBZ cord-280642-cvxni7cd 138 10 the the DT cord-280642-cvxni7cd 138 11 data data NN cord-280642-cvxni7cd 138 12 processor processor NN cord-280642-cvxni7cd 138 13 ; ; : cord-280642-cvxni7cd 138 14 and and CC cord-280642-cvxni7cd 138 15 the the DT cord-280642-cvxni7cd 138 16 key key JJ cord-280642-cvxni7cd 138 17 researchers researcher NNS cord-280642-cvxni7cd 138 18 on on IN cord-280642-cvxni7cd 138 19 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 138 20 are be VBP cord-280642-cvxni7cd 138 21 acting act VBG cord-280642-cvxni7cd 138 22 on on IN cord-280642-cvxni7cd 138 23 behalf behalf NN cord-280642-cvxni7cd 138 24 of of IN cord-280642-cvxni7cd 138 25 NHS NHS NNP cord-280642-cvxni7cd 138 26 England England NNP cord-280642-cvxni7cd 138 27 . . . cord-280642-cvxni7cd 139 1 This this DT cord-280642-cvxni7cd 139 2 implementation implementation NN cord-280642-cvxni7cd 139 3 of of IN cord-280642-cvxni7cd 139 4 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 139 5 is be VBZ cord-280642-cvxni7cd 139 6 hosted host VBN cord-280642-cvxni7cd 139 7 within within IN cord-280642-cvxni7cd 139 8 the the DT cord-280642-cvxni7cd 139 9 TPP TPP NNP cord-280642-cvxni7cd 139 10 environment environment NN cord-280642-cvxni7cd 139 11 which which WDT cord-280642-cvxni7cd 139 12 is be VBZ cord-280642-cvxni7cd 139 13 accredited accredit VBN cord-280642-cvxni7cd 139 14 to to IN cord-280642-cvxni7cd 139 15 the the DT cord-280642-cvxni7cd 139 16 ISO ISO NNP cord-280642-cvxni7cd 139 17 27001 27001 CD cord-280642-cvxni7cd 139 18 information information NN cord-280642-cvxni7cd 139 19 security security NN cord-280642-cvxni7cd 139 20 standard standard NN cord-280642-cvxni7cd 139 21 and and CC cord-280642-cvxni7cd 139 22 is be VBZ cord-280642-cvxni7cd 139 23 NHS NHS NNP cord-280642-cvxni7cd 139 24 IG IG NNP cord-280642-cvxni7cd 139 25 Toolkit Toolkit NNP cord-280642-cvxni7cd 139 26 compliant compliant NN cord-280642-cvxni7cd 139 27 ; ; : cord-280642-cvxni7cd 139 28 38,39 38,39 CD cord-280642-cvxni7cd 139 29 patient patient NN cord-280642-cvxni7cd 139 30 data data NN cord-280642-cvxni7cd 139 31 has have VBZ cord-280642-cvxni7cd 139 32 been be VBN cord-280642-cvxni7cd 139 33 pseudonymised pseudonymise VBN cord-280642-cvxni7cd 139 34 for for IN cord-280642-cvxni7cd 139 35 analysis analysis NN cord-280642-cvxni7cd 139 36 and and CC cord-280642-cvxni7cd 139 37 linkage linkage NN cord-280642-cvxni7cd 139 38 using use VBG cord-280642-cvxni7cd 139 39 industry industry NN cord-280642-cvxni7cd 139 40 standard standard JJ cord-280642-cvxni7cd 139 41 cryptographic cryptographic JJ cord-280642-cvxni7cd 139 42 hashing hashing NN cord-280642-cvxni7cd 139 43 techniques technique NNS cord-280642-cvxni7cd 139 44 ; ; : cord-280642-cvxni7cd 139 45 all all DT cord-280642-cvxni7cd 139 46 pseudonymised pseudonymised JJ cord-280642-cvxni7cd 139 47 datasets dataset NNS cord-280642-cvxni7cd 139 48 transmitted transmit VBN cord-280642-cvxni7cd 139 49 for for IN cord-280642-cvxni7cd 139 50 linkage linkage NN cord-280642-cvxni7cd 139 51 onto onto IN cord-280642-cvxni7cd 139 52 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 139 53 are be VBP cord-280642-cvxni7cd 139 54 encrypted encrypt VBN cord-280642-cvxni7cd 139 55 ; ; : cord-280642-cvxni7cd 139 56 access access NN cord-280642-cvxni7cd 139 57 to to IN cord-280642-cvxni7cd 139 58 the the DT cord-280642-cvxni7cd 139 59 platform platform NN cord-280642-cvxni7cd 139 60 is be VBZ cord-280642-cvxni7cd 139 61 via via IN cord-280642-cvxni7cd 139 62 a a DT cord-280642-cvxni7cd 139 63 virtual virtual JJ cord-280642-cvxni7cd 139 64 private private JJ cord-280642-cvxni7cd 139 65 network network NN cord-280642-cvxni7cd 139 66 ( ( -LRB- cord-280642-cvxni7cd 139 67 VPN VPN NNP cord-280642-cvxni7cd 139 68 ) ) -RRB- cord-280642-cvxni7cd 139 69 connection connection NN cord-280642-cvxni7cd 139 70 , , , cord-280642-cvxni7cd 139 71 restricted restrict VBN cord-280642-cvxni7cd 139 72 to to IN cord-280642-cvxni7cd 139 73 a a DT cord-280642-cvxni7cd 139 74 small small JJ cord-280642-cvxni7cd 139 75 group group NN cord-280642-cvxni7cd 139 76 of of IN cord-280642-cvxni7cd 139 77 researchers researcher NNS cord-280642-cvxni7cd 139 78 , , , cord-280642-cvxni7cd 139 79 their -PRON- PRP$ cord-280642-cvxni7cd 139 80 specific specific JJ cord-280642-cvxni7cd 139 81 machine machine NN cord-280642-cvxni7cd 139 82 and and CC cord-280642-cvxni7cd 139 83 IP IP NNP cord-280642-cvxni7cd 139 84 address address NN cord-280642-cvxni7cd 139 85 ; ; : cord-280642-cvxni7cd 139 86 the the DT cord-280642-cvxni7cd 139 87 researchers researcher NNS cord-280642-cvxni7cd 139 88 hold hold VBP cord-280642-cvxni7cd 139 89 contracts contract NNS cord-280642-cvxni7cd 139 90 with with IN cord-280642-cvxni7cd 139 91 NHS NHS NNP cord-280642-cvxni7cd 139 92 England England NNP cord-280642-cvxni7cd 139 93 and and CC cord-280642-cvxni7cd 139 94 only only RB cord-280642-cvxni7cd 139 95 access access VB cord-280642-cvxni7cd 139 96 the the DT cord-280642-cvxni7cd 139 97 platform platform NN cord-280642-cvxni7cd 139 98 to to TO cord-280642-cvxni7cd 139 99 initiate initiate VB cord-280642-cvxni7cd 139 100 database database NN cord-280642-cvxni7cd 139 101 queries query NNS cord-280642-cvxni7cd 139 102 and and CC cord-280642-cvxni7cd 139 103 statistical statistical JJ cord-280642-cvxni7cd 139 104 models model NNS cord-280642-cvxni7cd 139 105 ; ; : cord-280642-cvxni7cd 139 106 all all DT cord-280642-cvxni7cd 139 107 database database NN cord-280642-cvxni7cd 139 108 activity activity NN cord-280642-cvxni7cd 139 109 is be VBZ cord-280642-cvxni7cd 139 110 logged log VBN cord-280642-cvxni7cd 139 111 ; ; : cord-280642-cvxni7cd 139 112 only only RB cord-280642-cvxni7cd 139 113 aggregate aggregate JJ cord-280642-cvxni7cd 139 114 statistical statistical JJ cord-280642-cvxni7cd 139 115 outputs output NNS cord-280642-cvxni7cd 139 116 leave leave VBP cord-280642-cvxni7cd 139 117 the the DT cord-280642-cvxni7cd 139 118 platform platform NN cord-280642-cvxni7cd 139 119 environment environment NN cord-280642-cvxni7cd 139 120 following follow VBG cord-280642-cvxni7cd 139 121 best good JJS cord-280642-cvxni7cd 139 122 practice practice NN cord-280642-cvxni7cd 139 123 for for IN cord-280642-cvxni7cd 139 124 anonymisation anonymisation NN cord-280642-cvxni7cd 139 125 of of IN cord-280642-cvxni7cd 139 126 results result NNS cord-280642-cvxni7cd 139 127 such such JJ cord-280642-cvxni7cd 139 128 as as IN cord-280642-cvxni7cd 139 129 statistical statistical JJ cord-280642-cvxni7cd 139 130 disclosure disclosure NN cord-280642-cvxni7cd 139 131 control control NN cord-280642-cvxni7cd 139 132 for for IN cord-280642-cvxni7cd 139 133 low low JJ cord-280642-cvxni7cd 139 134 cell cell NN cord-280642-cvxni7cd 139 135 counts count NNS cord-280642-cvxni7cd 139 136 . . . cord-280642-cvxni7cd 140 1 40 40 CD cord-280642-cvxni7cd 141 1 The the DT cord-280642-cvxni7cd 141 2 . . . cord-280642-cvxni7cd 142 1 CC CC NNP cord-280642-cvxni7cd 142 2 - - : cord-280642-cvxni7cd 142 3 BY by IN cord-280642-cvxni7cd 142 4 4.0 4.0 CD cord-280642-cvxni7cd 142 5 International international JJ cord-280642-cvxni7cd 142 6 license license NN cord-280642-cvxni7cd 143 1 It -PRON- PRP cord-280642-cvxni7cd 143 2 is be VBZ cord-280642-cvxni7cd 143 3 made make VBN cord-280642-cvxni7cd 143 4 available available JJ cord-280642-cvxni7cd 143 5 under under IN cord-280642-cvxni7cd 143 6 a a DT cord-280642-cvxni7cd 144 1 is be VBZ cord-280642-cvxni7cd 144 2 the the DT cord-280642-cvxni7cd 144 3 author author NN cord-280642-cvxni7cd 144 4 / / SYM cord-280642-cvxni7cd 144 5 funder funder NN cord-280642-cvxni7cd 144 6 , , , cord-280642-cvxni7cd 144 7 who who WP cord-280642-cvxni7cd 144 8 has have VBZ cord-280642-cvxni7cd 144 9 granted grant VBN cord-280642-cvxni7cd 144 10 medRxiv medRxiv NNS cord-280642-cvxni7cd 144 11 a a DT cord-280642-cvxni7cd 144 12 license license NN cord-280642-cvxni7cd 144 13 to to TO cord-280642-cvxni7cd 144 14 display display VB cord-280642-cvxni7cd 144 15 the the DT cord-280642-cvxni7cd 144 16 preprint preprint NN cord-280642-cvxni7cd 144 17 in in IN cord-280642-cvxni7cd 144 18 perpetuity perpetuity NN cord-280642-cvxni7cd 144 19 . . . cord-280642-cvxni7cd 145 1 The the DT cord-280642-cvxni7cd 145 2 copyright copyright NN cord-280642-cvxni7cd 145 3 holder holder NN cord-280642-cvxni7cd 145 4 for for IN cord-280642-cvxni7cd 145 5 this this DT cord-280642-cvxni7cd 145 6 preprint preprint NN cord-280642-cvxni7cd 145 7 this this DT cord-280642-cvxni7cd 145 8 version version NN cord-280642-cvxni7cd 145 9 posted post VBN cord-280642-cvxni7cd 145 10 May May NNP cord-280642-cvxni7cd 145 11 7 7 CD cord-280642-cvxni7cd 145 12 , , , cord-280642-cvxni7cd 145 13 2020 2020 CD cord-280642-cvxni7cd 145 14 . . . cord-280642-cvxni7cd 146 1 to to TO cord-280642-cvxni7cd 146 2 require require VB cord-280642-cvxni7cd 146 3 organisations organisation NNS cord-280642-cvxni7cd 146 4 to to TO cord-280642-cvxni7cd 146 5 process process VB cord-280642-cvxni7cd 146 6 confidential confidential JJ cord-280642-cvxni7cd 146 7 patient patient JJ cord-280642-cvxni7cd 146 8 information information NN cord-280642-cvxni7cd 146 9 for for IN cord-280642-cvxni7cd 146 10 the the DT cord-280642-cvxni7cd 146 11 purposes purpose NNS cord-280642-cvxni7cd 146 12 of of IN cord-280642-cvxni7cd 146 13 protecting protect VBG cord-280642-cvxni7cd 146 14 public public JJ cord-280642-cvxni7cd 146 15 health health NN cord-280642-cvxni7cd 146 16 , , , cord-280642-cvxni7cd 146 17 providing provide VBG cord-280642-cvxni7cd 146 18 healthcare healthcare NN cord-280642-cvxni7cd 146 19 services service NNS cord-280642-cvxni7cd 146 20 to to IN cord-280642-cvxni7cd 146 21 the the DT cord-280642-cvxni7cd 146 22 public public NN cord-280642-cvxni7cd 146 23 and and CC cord-280642-cvxni7cd 146 24 monitoring monitoring NN cord-280642-cvxni7cd 146 25 and and CC cord-280642-cvxni7cd 146 26 managing manage VBG cord-280642-cvxni7cd 146 27 the the DT cord-280642-cvxni7cd 146 28 COVID-19 covid-19 JJ cord-280642-cvxni7cd 146 29 outbreak outbreak NN cord-280642-cvxni7cd 146 30 and and CC cord-280642-cvxni7cd 146 31 incidents incident NNS cord-280642-cvxni7cd 146 32 of of IN cord-280642-cvxni7cd 146 33 exposure exposure NN cord-280642-cvxni7cd 146 34 . . . cord-280642-cvxni7cd 147 1 41 41 CD cord-280642-cvxni7cd 147 2 Taken take VBN cord-280642-cvxni7cd 147 3 together together RB cord-280642-cvxni7cd 147 4 , , , cord-280642-cvxni7cd 147 5 these these DT cord-280642-cvxni7cd 147 6 provide provide VBP cord-280642-cvxni7cd 147 7 the the DT cord-280642-cvxni7cd 147 8 legal legal JJ cord-280642-cvxni7cd 147 9 bases basis NNS cord-280642-cvxni7cd 147 10 to to TO cord-280642-cvxni7cd 147 11 link link VB cord-280642-cvxni7cd 147 12 patient patient NN cord-280642-cvxni7cd 147 13 datasets dataset NNS cord-280642-cvxni7cd 147 14 on on IN cord-280642-cvxni7cd 147 15 the the DT cord-280642-cvxni7cd 147 16 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 147 17 platform platform NN cord-280642-cvxni7cd 147 18 . . . cord-280642-cvxni7cd 148 1 This this DT cord-280642-cvxni7cd 148 2 study study NN cord-280642-cvxni7cd 148 3 was be VBD cord-280642-cvxni7cd 148 4 approved approve VBN cord-280642-cvxni7cd 148 5 by by IN cord-280642-cvxni7cd 148 6 the the DT cord-280642-cvxni7cd 148 7 Health Health NNP cord-280642-cvxni7cd 148 8 Research Research NNP cord-280642-cvxni7cd 148 9 Authority Authority NNP cord-280642-cvxni7cd 148 10 ( ( -LRB- cord-280642-cvxni7cd 148 11 REC REC NNP cord-280642-cvxni7cd 148 12 reference reference NN cord-280642-cvxni7cd 148 13 20 20 CD cord-280642-cvxni7cd 148 14 / / SYM cord-280642-cvxni7cd 148 15 LO/0651 LO/0651 NNS cord-280642-cvxni7cd 148 16 ) ) -RRB- cord-280642-cvxni7cd 148 17 and and CC cord-280642-cvxni7cd 148 18 by by IN cord-280642-cvxni7cd 148 19 the the DT cord-280642-cvxni7cd 148 20 LSHTM LSHTM NNP cord-280642-cvxni7cd 148 21 Ethics Ethics NNP cord-280642-cvxni7cd 148 22 Board Board NNP cord-280642-cvxni7cd 148 23 ( ( -LRB- cord-280642-cvxni7cd 148 24 reference reference NN cord-280642-cvxni7cd 148 25 21863 21863 CD cord-280642-cvxni7cd 148 26 ) ) -RRB- cord-280642-cvxni7cd 148 27 . . . cord-280642-cvxni7cd 149 1 Data data NN cord-280642-cvxni7cd 149 2 management management NN cord-280642-cvxni7cd 149 3 was be VBD cord-280642-cvxni7cd 149 4 performed perform VBN cord-280642-cvxni7cd 149 5 using use VBG cord-280642-cvxni7cd 149 6 Python Python NNP cord-280642-cvxni7cd 149 7 3.8 3.8 CD cord-280642-cvxni7cd 149 8 and and CC cord-280642-cvxni7cd 149 9 SQL SQL NNP cord-280642-cvxni7cd 149 10 , , , cord-280642-cvxni7cd 149 11 with with IN cord-280642-cvxni7cd 149 12 analysis analysis NN cord-280642-cvxni7cd 149 13 carried carry VBN cord-280642-cvxni7cd 149 14 out out RP cord-280642-cvxni7cd 149 15 using use VBG cord-280642-cvxni7cd 149 16 Stata Stata NNP cord-280642-cvxni7cd 149 17 16.1 16.1 CD cord-280642-cvxni7cd 149 18 / / SYM cord-280642-cvxni7cd 149 19 Python Python NNP cord-280642-cvxni7cd 149 20 . . . cord-280642-cvxni7cd 150 1 All all DT cord-280642-cvxni7cd 150 2 code code NN cord-280642-cvxni7cd 150 3 for for IN cord-280642-cvxni7cd 150 4 data data NN cord-280642-cvxni7cd 150 5 management management NN cord-280642-cvxni7cd 150 6 and and CC cord-280642-cvxni7cd 150 7 analysis analysis NN cord-280642-cvxni7cd 150 8 is be VBZ cord-280642-cvxni7cd 150 9 archived archive VBN cord-280642-cvxni7cd 150 10 online online RB cord-280642-cvxni7cd 150 11 at at IN cord-280642-cvxni7cd 150 12 https://github.com/ebmdatalab/opensafel https://github.com/ebmdatalab/opensafel NNP cord-280642-cvxni7cd 150 13 y y NNP cord-280642-cvxni7cd 150 14 - - HYPH cord-280642-cvxni7cd 150 15 risk risk NN cord-280642-cvxni7cd 150 16 - - HYPH cord-280642-cvxni7cd 150 17 factors factor NNS cord-280642-cvxni7cd 150 18 - - : cord-280642-cvxni7cd 150 19 research research NN cord-280642-cvxni7cd 150 20 . . . cord-280642-cvxni7cd 151 1 All all DT cord-280642-cvxni7cd 151 2 clinical clinical JJ cord-280642-cvxni7cd 151 3 and and CC cord-280642-cvxni7cd 151 4 medicines medicine NNS cord-280642-cvxni7cd 151 5 codelists codelist NNS cord-280642-cvxni7cd 151 6 are be VBP cord-280642-cvxni7cd 151 7 openly openly RB cord-280642-cvxni7cd 151 8 available available JJ cord-280642-cvxni7cd 151 9 for for IN cord-280642-cvxni7cd 151 10 inspection inspection NN cord-280642-cvxni7cd 151 11 and and CC cord-280642-cvxni7cd 151 12 reuse reuse NN cord-280642-cvxni7cd 151 13 at at IN cord-280642-cvxni7cd 151 14 https://codelists.opensafely.org/. https://codelists.opensafely.org/. NNP cord-280642-cvxni7cd 151 15 Patients Patients NNPS cord-280642-cvxni7cd 151 16 were be VBD cord-280642-cvxni7cd 151 17 not not RB cord-280642-cvxni7cd 151 18 formally formally RB cord-280642-cvxni7cd 151 19 involved involve VBN cord-280642-cvxni7cd 151 20 in in IN cord-280642-cvxni7cd 151 21 developing develop VBG cord-280642-cvxni7cd 151 22 this this DT cord-280642-cvxni7cd 151 23 specific specific JJ cord-280642-cvxni7cd 151 24 study study NN cord-280642-cvxni7cd 151 25 design design NN cord-280642-cvxni7cd 151 26 . . . cord-280642-cvxni7cd 152 1 We -PRON- PRP cord-280642-cvxni7cd 152 2 have have VBP cord-280642-cvxni7cd 152 3 developed develop VBN cord-280642-cvxni7cd 152 4 a a DT cord-280642-cvxni7cd 152 5 publicly publicly RB cord-280642-cvxni7cd 152 6 available available JJ cord-280642-cvxni7cd 152 7 website website NN cord-280642-cvxni7cd 152 8 https://opensafely.org/ https://opensafely.org/ NNP cord-280642-cvxni7cd 152 9 allowing allow VBG cord-280642-cvxni7cd 152 10 any any DT cord-280642-cvxni7cd 152 11 patient patient NN cord-280642-cvxni7cd 152 12 or or CC cord-280642-cvxni7cd 152 13 member member NN cord-280642-cvxni7cd 152 14 of of IN cord-280642-cvxni7cd 152 15 the the DT cord-280642-cvxni7cd 152 16 public public NN cord-280642-cvxni7cd 152 17 to to TO cord-280642-cvxni7cd 152 18 contact contact VB cord-280642-cvxni7cd 152 19 us -PRON- PRP cord-280642-cvxni7cd 152 20 regarding regard VBG cord-280642-cvxni7cd 152 21 this this DT cord-280642-cvxni7cd 152 22 study study NN cord-280642-cvxni7cd 152 23 or or CC cord-280642-cvxni7cd 152 24 the the DT cord-280642-cvxni7cd 152 25 broader broad JJR cord-280642-cvxni7cd 152 26 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 152 27 project project NN cord-280642-cvxni7cd 152 28 . . . cord-280642-cvxni7cd 153 1 This this DT cord-280642-cvxni7cd 153 2 feedback feedback NN cord-280642-cvxni7cd 153 3 will will MD cord-280642-cvxni7cd 153 4 be be VB cord-280642-cvxni7cd 153 5 used use VBN cord-280642-cvxni7cd 153 6 to to TO cord-280642-cvxni7cd 153 7 refine refine VB cord-280642-cvxni7cd 153 8 and and CC cord-280642-cvxni7cd 153 9 prioritise prioritise VB cord-280642-cvxni7cd 153 10 our -PRON- PRP$ cord-280642-cvxni7cd 153 11 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 153 12 activities activity NNS cord-280642-cvxni7cd 153 13 . . . cord-280642-cvxni7cd 154 1 17,425,445 17,425,445 CD cord-280642-cvxni7cd 154 2 adults adult NNS cord-280642-cvxni7cd 154 3 were be VBD cord-280642-cvxni7cd 154 4 included include VBN cord-280642-cvxni7cd 154 5 ( ( -LRB- cord-280642-cvxni7cd 154 6 Figure figure NN cord-280642-cvxni7cd 154 7 1 1 CD cord-280642-cvxni7cd 154 8 ) ) -RRB- cord-280642-cvxni7cd 154 9 . . . cord-280642-cvxni7cd 155 1 Table table NN cord-280642-cvxni7cd 155 2 _SP cord-280642-cvxni7cd 155 3 1 1 CD cord-280642-cvxni7cd 155 4 shows show VBZ cord-280642-cvxni7cd 155 5 distributions distribution NNS cord-280642-cvxni7cd 155 6 of of IN cord-280642-cvxni7cd 155 7 demographics demographic NNS cord-280642-cvxni7cd 155 8 and and CC cord-280642-cvxni7cd 155 9 baseline baseline JJ cord-280642-cvxni7cd 155 10 comorbidities comorbiditie NNS cord-280642-cvxni7cd 155 11 . . . cord-280642-cvxni7cd 156 1 The the DT cord-280642-cvxni7cd 156 2 overall overall JJ cord-280642-cvxni7cd 156 3 cumulative cumulative JJ cord-280642-cvxni7cd 156 4 incidence incidence NN cord-280642-cvxni7cd 156 5 of of IN cord-280642-cvxni7cd 156 6 COVID-19 covid-19 JJ cord-280642-cvxni7cd 156 7 hospital hospital NN cord-280642-cvxni7cd 156 8 death death NN cord-280642-cvxni7cd 156 9 at at IN cord-280642-cvxni7cd 156 10 80 80 CD cord-280642-cvxni7cd 156 11 days day NNS cord-280642-cvxni7cd 156 12 from from IN cord-280642-cvxni7cd 156 13 the the DT cord-280642-cvxni7cd 156 14 study study NN cord-280642-cvxni7cd 156 15 start start NN cord-280642-cvxni7cd 156 16 date date NN cord-280642-cvxni7cd 156 17 was be VBD cord-280642-cvxni7cd 156 18 < < NNP cord-280642-cvxni7cd 156 19 0.01 0.01 CD cord-280642-cvxni7cd 156 20 % % NN cord-280642-cvxni7cd 156 21 in in IN cord-280642-cvxni7cd 156 22 those those DT cord-280642-cvxni7cd 156 23 aged age VBN cord-280642-cvxni7cd 156 24 18 18 CD cord-280642-cvxni7cd 156 25 - - SYM cord-280642-cvxni7cd 156 26 39 39 CD cord-280642-cvxni7cd 156 27 years year NNS cord-280642-cvxni7cd 156 28 , , , cord-280642-cvxni7cd 156 29 rising rise VBG cord-280642-cvxni7cd 156 30 to to IN cord-280642-cvxni7cd 156 31 0.35 0.35 CD cord-280642-cvxni7cd 156 32 % % NN cord-280642-cvxni7cd 156 33 and and CC cord-280642-cvxni7cd 156 34 0.17 0.17 CD cord-280642-cvxni7cd 156 35 % % NN cord-280642-cvxni7cd 156 36 in in IN cord-280642-cvxni7cd 156 37 men man NNS cord-280642-cvxni7cd 156 38 and and CC cord-280642-cvxni7cd 156 39 women woman NNS cord-280642-cvxni7cd 156 40 respectively respectively RB cord-280642-cvxni7cd 156 41 aged age VBN cord-280642-cvxni7cd 156 42 ≥80 ≥80 NNP cord-280642-cvxni7cd 156 43 years year NNS cord-280642-cvxni7cd 156 44 , , , cord-280642-cvxni7cd 156 45 with with IN cord-280642-cvxni7cd 156 46 a a DT cord-280642-cvxni7cd 156 47 trend trend NN cord-280642-cvxni7cd 156 48 by by IN cord-280642-cvxni7cd 156 49 age age NN cord-280642-cvxni7cd 157 1 ( ( -LRB- cord-280642-cvxni7cd 157 2 Figure figure NN cord-280642-cvxni7cd 157 3 _SP cord-280642-cvxni7cd 157 4 2 2 CD cord-280642-cvxni7cd 157 5 ) ) -RRB- cord-280642-cvxni7cd 157 6 . . . cord-280642-cvxni7cd 158 1 Associations association NNS cord-280642-cvxni7cd 158 2 between between IN cord-280642-cvxni7cd 158 3 patient patient NN cord-280642-cvxni7cd 158 4 - - HYPH cord-280642-cvxni7cd 158 5 level level NN cord-280642-cvxni7cd 158 6 factors factor NNS cord-280642-cvxni7cd 158 7 and and CC cord-280642-cvxni7cd 158 8 risk risk NN cord-280642-cvxni7cd 158 9 of of IN cord-280642-cvxni7cd 158 10 COVID-19 covid-19 JJ cord-280642-cvxni7cd 158 11 hospital hospital NN cord-280642-cvxni7cd 158 12 death death NN cord-280642-cvxni7cd 158 13 are be VBP cord-280642-cvxni7cd 158 14 shown show VBN cord-280642-cvxni7cd 158 15 in in IN cord-280642-cvxni7cd 158 16 Table Table NNP cord-280642-cvxni7cd 158 17 2 2 CD cord-280642-cvxni7cd 158 18 and and CC cord-280642-cvxni7cd 158 19 Figure figure NN cord-280642-cvxni7cd 158 20 3 3 CD cord-280642-cvxni7cd 158 21 . . . cord-280642-cvxni7cd 159 1 Increasing increase VBG cord-280642-cvxni7cd 159 2 age age NN cord-280642-cvxni7cd 159 3 was be VBD cord-280642-cvxni7cd 159 4 strongly strongly RB cord-280642-cvxni7cd 159 5 associated associate VBN cord-280642-cvxni7cd 159 6 with with IN cord-280642-cvxni7cd 159 7 risk risk NN cord-280642-cvxni7cd 159 8 , , , cord-280642-cvxni7cd 159 9 with with IN cord-280642-cvxni7cd 159 10 the the DT cord-280642-cvxni7cd 159 11 ≥80 ≥80 NNP cord-280642-cvxni7cd 159 12 years year NNS cord-280642-cvxni7cd 159 13 age age NN cord-280642-cvxni7cd 159 14 group group NN cord-280642-cvxni7cd 159 15 having have VBG cord-280642-cvxni7cd 159 16 more more JJR cord-280642-cvxni7cd 159 17 than than IN cord-280642-cvxni7cd 159 18 12-fold 12-fold CD cord-280642-cvxni7cd 159 19 increased increase VBN cord-280642-cvxni7cd 159 20 risk risk NN cord-280642-cvxni7cd 159 21 compared compare VBN cord-280642-cvxni7cd 159 22 with with IN cord-280642-cvxni7cd 159 23 those those DT cord-280642-cvxni7cd 159 24 aged age VBN cord-280642-cvxni7cd 159 25 50 50 CD cord-280642-cvxni7cd 159 26 - - SYM cord-280642-cvxni7cd 159 27 59 59 CD cord-280642-cvxni7cd 159 28 years year NNS cord-280642-cvxni7cd 159 29 . . . cord-280642-cvxni7cd 160 1 CC CC NNP cord-280642-cvxni7cd 160 2 - - : cord-280642-cvxni7cd 160 3 BY by IN cord-280642-cvxni7cd 160 4 4.0 4.0 CD cord-280642-cvxni7cd 160 5 International international JJ cord-280642-cvxni7cd 160 6 license license NN cord-280642-cvxni7cd 161 1 It -PRON- PRP cord-280642-cvxni7cd 161 2 is be VBZ cord-280642-cvxni7cd 161 3 made make VBN cord-280642-cvxni7cd 161 4 available available JJ cord-280642-cvxni7cd 161 5 under under IN cord-280642-cvxni7cd 161 6 a a DT cord-280642-cvxni7cd 162 1 is be VBZ cord-280642-cvxni7cd 162 2 the the DT cord-280642-cvxni7cd 162 3 author author NN cord-280642-cvxni7cd 162 4 / / SYM cord-280642-cvxni7cd 162 5 funder funder NN cord-280642-cvxni7cd 162 6 , , , cord-280642-cvxni7cd 162 7 who who WP cord-280642-cvxni7cd 162 8 has have VBZ cord-280642-cvxni7cd 162 9 granted grant VBN cord-280642-cvxni7cd 162 10 medRxiv medRxiv NNS cord-280642-cvxni7cd 162 11 a a DT cord-280642-cvxni7cd 162 12 license license NN cord-280642-cvxni7cd 162 13 to to TO cord-280642-cvxni7cd 162 14 display display VB cord-280642-cvxni7cd 162 15 the the DT cord-280642-cvxni7cd 162 16 preprint preprint NN cord-280642-cvxni7cd 162 17 in in IN cord-280642-cvxni7cd 162 18 perpetuity perpetuity NN cord-280642-cvxni7cd 162 19 . . . cord-280642-cvxni7cd 163 1 The the DT cord-280642-cvxni7cd 163 2 copyright copyright NN cord-280642-cvxni7cd 163 3 holder holder NN cord-280642-cvxni7cd 163 4 for for IN cord-280642-cvxni7cd 163 5 this this DT cord-280642-cvxni7cd 163 6 preprint preprint NN cord-280642-cvxni7cd 163 7 this this DT cord-280642-cvxni7cd 163 8 version version NN cord-280642-cvxni7cd 163 9 posted post VBN cord-280642-cvxni7cd 163 10 May May NNP cord-280642-cvxni7cd 163 11 7 7 CD cord-280642-cvxni7cd 163 12 , , , cord-280642-cvxni7cd 163 13 2020 2020 CD cord-280642-cvxni7cd 163 14 . . . cord-280642-cvxni7cd 164 1 Figure Figure NNP cord-280642-cvxni7cd 164 2 A1 A1 NNP cord-280642-cvxni7cd 164 3 ) ) -RRB- cord-280642-cvxni7cd 164 4 , , , cord-280642-cvxni7cd 164 5 equivalent equivalent JJ cord-280642-cvxni7cd 164 6 to to IN cord-280642-cvxni7cd 164 7 risk risk NN cord-280642-cvxni7cd 164 8 increasing increase VBG cord-280642-cvxni7cd 164 9 exponentially exponentially RB cord-280642-cvxni7cd 164 10 with with IN cord-280642-cvxni7cd 164 11 age age NN cord-280642-cvxni7cd 164 12 . . . cord-280642-cvxni7cd 165 1 Male male JJ cord-280642-cvxni7cd 165 2 gender gender NN cord-280642-cvxni7cd 165 3 was be VBD cord-280642-cvxni7cd 165 4 associated associate VBN cord-280642-cvxni7cd 165 5 with with IN cord-280642-cvxni7cd 165 6 a a DT cord-280642-cvxni7cd 165 7 doubling doubling NN cord-280642-cvxni7cd 165 8 of of IN cord-280642-cvxni7cd 165 9 risk risk NN cord-280642-cvxni7cd 165 10 ( ( -LRB- cord-280642-cvxni7cd 165 11 fully fully RB cord-280642-cvxni7cd 165 12 adjusted adjust VBN cord-280642-cvxni7cd 165 13 HR HR NNP cord-280642-cvxni7cd 165 14 1.99 1.99 CD cord-280642-cvxni7cd 165 15 , , , cord-280642-cvxni7cd 165 16 1.88 1.88 CD cord-280642-cvxni7cd 165 17 - - SYM cord-280642-cvxni7cd 165 18 2.10 2.10 CD cord-280642-cvxni7cd 165 19 ) ) -RRB- cord-280642-cvxni7cd 165 20 . . . cord-280642-cvxni7cd 166 1 All all DT cord-280642-cvxni7cd 166 2 non non JJ cord-280642-cvxni7cd 166 3 - - JJ cord-280642-cvxni7cd 166 4 white white JJ cord-280642-cvxni7cd 166 5 ethnic ethnic JJ cord-280642-cvxni7cd 166 6 groups group NNS cord-280642-cvxni7cd 166 7 had have VBD cord-280642-cvxni7cd 166 8 higher high JJR cord-280642-cvxni7cd 166 9 risk risk NN cord-280642-cvxni7cd 166 10 than than IN cord-280642-cvxni7cd 166 11 those those DT cord-280642-cvxni7cd 166 12 with with IN cord-280642-cvxni7cd 166 13 white white JJ cord-280642-cvxni7cd 166 14 ethnicity ethnicity NN cord-280642-cvxni7cd 166 15 : : : cord-280642-cvxni7cd 167 1 HRs hr NNS cord-280642-cvxni7cd 167 2 adjusted adjust VBN cord-280642-cvxni7cd 167 3 for for IN cord-280642-cvxni7cd 167 4 age age NN cord-280642-cvxni7cd 167 5 and and CC cord-280642-cvxni7cd 167 6 sex sex NN cord-280642-cvxni7cd 167 7 only only RB cord-280642-cvxni7cd 167 8 ranged range VBD cord-280642-cvxni7cd 167 9 from from IN cord-280642-cvxni7cd 167 10 1.83 1.83 CD cord-280642-cvxni7cd 167 11 - - HYPH cord-280642-cvxni7cd 167 12 2.17 2.17 CD cord-280642-cvxni7cd 167 13 for for IN cord-280642-cvxni7cd 167 14 Black black JJ cord-280642-cvxni7cd 167 15 , , , cord-280642-cvxni7cd 167 16 Asian asian JJ cord-280642-cvxni7cd 167 17 / / SYM cord-280642-cvxni7cd 167 18 Asian asian JJ cord-280642-cvxni7cd 167 19 British british JJ cord-280642-cvxni7cd 167 20 and and CC cord-280642-cvxni7cd 167 21 mixed mixed JJ cord-280642-cvxni7cd 167 22 ethnicities ethnicity NNS cord-280642-cvxni7cd 167 23 compared compare VBN cord-280642-cvxni7cd 167 24 to to IN cord-280642-cvxni7cd 167 25 white white JJ cord-280642-cvxni7cd 167 26 ; ; : cord-280642-cvxni7cd 167 27 these these DT cord-280642-cvxni7cd 167 28 attenuated attenuate VBN cord-280642-cvxni7cd 167 29 to to IN cord-280642-cvxni7cd 167 30 1.62 1.62 CD cord-280642-cvxni7cd 167 31 - - SYM cord-280642-cvxni7cd 167 32 1.71 1.71 CD cord-280642-cvxni7cd 167 33 on on IN cord-280642-cvxni7cd 167 34 adjustment adjustment NN cord-280642-cvxni7cd 167 35 for for IN cord-280642-cvxni7cd 167 36 all all DT cord-280642-cvxni7cd 167 37 included include VBN cord-280642-cvxni7cd 167 38 risk risk NN cord-280642-cvxni7cd 167 39 factors factor NNS cord-280642-cvxni7cd 167 40 . . . cord-280642-cvxni7cd 168 1 Increasing increase VBG cord-280642-cvxni7cd 168 2 risks risk NNS cord-280642-cvxni7cd 168 3 were be VBD cord-280642-cvxni7cd 168 4 seen see VBN cord-280642-cvxni7cd 168 5 with with IN cord-280642-cvxni7cd 168 6 increasing increase VBG cord-280642-cvxni7cd 168 7 levels level NNS cord-280642-cvxni7cd 168 8 of of IN cord-280642-cvxni7cd 168 9 deprivation deprivation NN cord-280642-cvxni7cd 168 10 , , , cord-280642-cvxni7cd 168 11 and and CC cord-280642-cvxni7cd 168 12 with with IN cord-280642-cvxni7cd 168 13 increasing increase VBG cord-280642-cvxni7cd 168 14 levels level NNS cord-280642-cvxni7cd 168 15 of of IN cord-280642-cvxni7cd 168 16 obesity obesity NN cord-280642-cvxni7cd 168 17 ( ( -LRB- cord-280642-cvxni7cd 168 18 BMI BMI NNP cord-280642-cvxni7cd 168 19 > > XX cord-280642-cvxni7cd 168 20 40 40 CD cord-280642-cvxni7cd 168 21 fully fully RB cord-280642-cvxni7cd 168 22 adjusted adjust VBN cord-280642-cvxni7cd 168 23 HR hr NN cord-280642-cvxni7cd 168 24 2.27 2.27 CD cord-280642-cvxni7cd 168 25 , , , cord-280642-cvxni7cd 168 26 95 95 CD cord-280642-cvxni7cd 168 27 % % NN cord-280642-cvxni7cd 168 28 CI ci NN cord-280642-cvxni7cd 169 1 1.99 1.99 CD cord-280642-cvxni7cd 169 2 - - SYM cord-280642-cvxni7cd 169 3 2.58 2.58 CD cord-280642-cvxni7cd 169 4 ) ) -RRB- cord-280642-cvxni7cd 169 5 . . . cord-280642-cvxni7cd 170 1 Both both DT cord-280642-cvxni7cd 170 2 current current JJ cord-280642-cvxni7cd 170 3 and and CC cord-280642-cvxni7cd 170 4 former former JJ cord-280642-cvxni7cd 170 5 smoking smoking NN cord-280642-cvxni7cd 170 6 were be VBD cord-280642-cvxni7cd 170 7 associated associate VBN cord-280642-cvxni7cd 170 8 with with IN cord-280642-cvxni7cd 170 9 higher high JJR cord-280642-cvxni7cd 170 10 risk risk NN cord-280642-cvxni7cd 170 11 in in IN cord-280642-cvxni7cd 170 12 models model NNS cord-280642-cvxni7cd 170 13 adjusted adjust VBN cord-280642-cvxni7cd 170 14 for for IN cord-280642-cvxni7cd 170 15 age age NN cord-280642-cvxni7cd 170 16 and and CC cord-280642-cvxni7cd 170 17 sex sex NN cord-280642-cvxni7cd 170 18 only only RB cord-280642-cvxni7cd 170 19 , , , cord-280642-cvxni7cd 170 20 but but CC cord-280642-cvxni7cd 170 21 in in IN cord-280642-cvxni7cd 170 22 the the DT cord-280642-cvxni7cd 170 23 fully fully RB cord-280642-cvxni7cd 170 24 adjusted adjust VBN cord-280642-cvxni7cd 170 25 model model NN cord-280642-cvxni7cd 170 26 there there EX cord-280642-cvxni7cd 170 27 was be VBD cord-280642-cvxni7cd 170 28 weak weak JJ cord-280642-cvxni7cd 170 29 evidence evidence NN cord-280642-cvxni7cd 170 30 of of IN cord-280642-cvxni7cd 170 31 a a DT cord-280642-cvxni7cd 170 32 slightly slightly RB cord-280642-cvxni7cd 170 33 lower low JJR cord-280642-cvxni7cd 170 34 risk risk NN cord-280642-cvxni7cd 170 35 in in IN cord-280642-cvxni7cd 170 36 current current JJ cord-280642-cvxni7cd 170 37 smokers smoker NNS cord-280642-cvxni7cd 170 38 ( ( -LRB- cord-280642-cvxni7cd 170 39 fully fully RB cord-280642-cvxni7cd 170 40 adjusted adjust VBN cord-280642-cvxni7cd 170 41 HRs hr NNS cord-280642-cvxni7cd 170 42 0.88 0.88 CD cord-280642-cvxni7cd 170 43 , , , cord-280642-cvxni7cd 170 44 CI CI NNP cord-280642-cvxni7cd 170 45 0.79 0.79 CD cord-280642-cvxni7cd 170 46 - - HYPH cord-280642-cvxni7cd 170 47 0.99 0.99 CD cord-280642-cvxni7cd 170 48 ) ) -RRB- cord-280642-cvxni7cd 170 49 . . . cord-280642-cvxni7cd 171 1 In in IN cord-280642-cvxni7cd 171 2 post post JJ cord-280642-cvxni7cd 171 3 - - JJ cord-280642-cvxni7cd 171 4 hoc hoc JJ cord-280642-cvxni7cd 171 5 analyses analysis NNS cord-280642-cvxni7cd 171 6 we -PRON- PRP cord-280642-cvxni7cd 171 7 added add VBD cord-280642-cvxni7cd 171 8 individual individual JJ cord-280642-cvxni7cd 171 9 covariates covariate NNS cord-280642-cvxni7cd 171 10 to to IN cord-280642-cvxni7cd 171 11 the the DT cord-280642-cvxni7cd 171 12 model model NN cord-280642-cvxni7cd 171 13 with with IN cord-280642-cvxni7cd 171 14 age age NN cord-280642-cvxni7cd 171 15 , , , cord-280642-cvxni7cd 171 16 sex sex NN cord-280642-cvxni7cd 171 17 and and CC cord-280642-cvxni7cd 171 18 smoking smoking NN cord-280642-cvxni7cd 171 19 to to TO cord-280642-cvxni7cd 171 20 explore explore VB cord-280642-cvxni7cd 171 21 this this DT cord-280642-cvxni7cd 171 22 further further RB cord-280642-cvxni7cd 171 23 : : : cord-280642-cvxni7cd 171 24 the the DT cord-280642-cvxni7cd 171 25 change change NN cord-280642-cvxni7cd 171 26 in in IN cord-280642-cvxni7cd 171 27 HR HR NNP cord-280642-cvxni7cd 171 28 appeared appear VBD cord-280642-cvxni7cd 171 29 to to TO cord-280642-cvxni7cd 171 30 be be VB cord-280642-cvxni7cd 171 31 largely largely RB cord-280642-cvxni7cd 171 32 driven drive VBN cord-280642-cvxni7cd 171 33 by by IN cord-280642-cvxni7cd 171 34 adjustment adjustment NN cord-280642-cvxni7cd 171 35 for for IN cord-280642-cvxni7cd 171 36 chronic chronic JJ cord-280642-cvxni7cd 171 37 respiratory respiratory JJ cord-280642-cvxni7cd 171 38 disease disease NN cord-280642-cvxni7cd 171 39 ( ( -LRB- cord-280642-cvxni7cd 171 40 HR HR NNP cord-280642-cvxni7cd 171 41 0.93 0.93 CD cord-280642-cvxni7cd 171 42 , , , cord-280642-cvxni7cd 171 43 0.83 0.83 CD cord-280642-cvxni7cd 171 44 - - SYM cord-280642-cvxni7cd 171 45 1.04 1.04 CD cord-280642-cvxni7cd 171 46 after after IN cord-280642-cvxni7cd 171 47 adjustment adjustment NN cord-280642-cvxni7cd 171 48 ) ) -RRB- cord-280642-cvxni7cd 171 49 and and CC cord-280642-cvxni7cd 171 50 deprivation deprivation NN cord-280642-cvxni7cd 171 51 ( ( -LRB- cord-280642-cvxni7cd 171 52 HR HR NNP cord-280642-cvxni7cd 171 53 0.98 0.98 CD cord-280642-cvxni7cd 171 54 , , , cord-280642-cvxni7cd 171 55 0.88 0.88 CD cord-280642-cvxni7cd 171 56 - - SYM cord-280642-cvxni7cd 171 57 1.10 1.10 CD cord-280642-cvxni7cd 171 58 after after IN cord-280642-cvxni7cd 171 59 adjustment adjustment NN cord-280642-cvxni7cd 171 60 ) ) -RRB- cord-280642-cvxni7cd 171 61 . . . cord-280642-cvxni7cd 172 1 Other other JJ cord-280642-cvxni7cd 172 2 individual individual JJ cord-280642-cvxni7cd 172 3 adjustments adjustment NNS cord-280642-cvxni7cd 172 4 did do VBD cord-280642-cvxni7cd 172 5 not not RB cord-280642-cvxni7cd 172 6 remove remove VB cord-280642-cvxni7cd 172 7 the the DT cord-280642-cvxni7cd 172 8 positive positive JJ cord-280642-cvxni7cd 172 9 association association NN cord-280642-cvxni7cd 172 10 between between IN cord-280642-cvxni7cd 172 11 current current JJ cord-280642-cvxni7cd 172 12 smoking smoking NN cord-280642-cvxni7cd 172 13 and and CC cord-280642-cvxni7cd 172 14 outcome outcome NN cord-280642-cvxni7cd 172 15 . . . cord-280642-cvxni7cd 173 1 We -PRON- PRP cord-280642-cvxni7cd 173 2 also also RB cord-280642-cvxni7cd 173 3 explored explore VBD cord-280642-cvxni7cd 173 4 confounding confound VBG cord-280642-cvxni7cd 173 5 by by IN cord-280642-cvxni7cd 173 6 ethnicity ethnicity NN cord-280642-cvxni7cd 173 7 , , , cord-280642-cvxni7cd 173 8 which which WDT cord-280642-cvxni7cd 173 9 was be VBD cord-280642-cvxni7cd 173 10 not not RB cord-280642-cvxni7cd 173 11 adjusted adjust VBN cord-280642-cvxni7cd 173 12 in in IN cord-280642-cvxni7cd 173 13 the the DT cord-280642-cvxni7cd 173 14 primary primary JJ cord-280642-cvxni7cd 173 15 model model NN cord-280642-cvxni7cd 173 16 : : : cord-280642-cvxni7cd 173 17 among among IN cord-280642-cvxni7cd 173 18 those those DT cord-280642-cvxni7cd 173 19 with with IN cord-280642-cvxni7cd 173 20 complete complete JJ cord-280642-cvxni7cd 173 21 ethnicity ethnicity NN cord-280642-cvxni7cd 173 22 , , , cord-280642-cvxni7cd 173 23 the the DT cord-280642-cvxni7cd 173 24 current current JJ cord-280642-cvxni7cd 173 25 smoking smoking NN cord-280642-cvxni7cd 173 26 HR hr NN cord-280642-cvxni7cd 173 27 adjusted adjust VBN cord-280642-cvxni7cd 173 28 for for IN cord-280642-cvxni7cd 173 29 all all DT cord-280642-cvxni7cd 173 30 variables variable NNS cord-280642-cvxni7cd 173 31 except except IN cord-280642-cvxni7cd 173 32 ethnicity ethnicity NN cord-280642-cvxni7cd 173 33 was be VBD cord-280642-cvxni7cd 173 34 similar similar JJ cord-280642-cvxni7cd 173 35 to to IN cord-280642-cvxni7cd 173 36 in in IN cord-280642-cvxni7cd 173 37 the the DT cord-280642-cvxni7cd 173 38 full full JJ cord-280642-cvxni7cd 173 39 study study NN cord-280642-cvxni7cd 173 40 population population NN cord-280642-cvxni7cd 173 41 ( ( -LRB- cord-280642-cvxni7cd 173 42 0.88 0.88 CD cord-280642-cvxni7cd 173 43 , , , cord-280642-cvxni7cd 173 44 0.78 0.78 CD cord-280642-cvxni7cd 173 45 - - SYM cord-280642-cvxni7cd 173 46 1.01 1.01 CD cord-280642-cvxni7cd 173 47 ) ) -RRB- cord-280642-cvxni7cd 173 48 but but CC cord-280642-cvxni7cd 173 49 this this DT cord-280642-cvxni7cd 173 50 moved move VBD cord-280642-cvxni7cd 173 51 towards towards IN cord-280642-cvxni7cd 173 52 the the DT cord-280642-cvxni7cd 173 53 null null NN cord-280642-cvxni7cd 173 54 on on IN cord-280642-cvxni7cd 173 55 adjustment adjustment NN cord-280642-cvxni7cd 173 56 for for IN cord-280642-cvxni7cd 173 57 ethnicity ethnicity NN cord-280642-cvxni7cd 173 58 ( ( -LRB- cord-280642-cvxni7cd 173 59 HR HR NNP cord-280642-cvxni7cd 173 60 0.94 0.94 CD cord-280642-cvxni7cd 173 61 , , , cord-280642-cvxni7cd 173 62 0.82 0.82 CD cord-280642-cvxni7cd 173 63 - - SYM cord-280642-cvxni7cd 173 64 1.07 1.07 CD cord-280642-cvxni7cd 173 65 ) ) -RRB- cord-280642-cvxni7cd 173 66 . . . cord-280642-cvxni7cd 173 67 . . . cord-280642-cvxni7cd 174 1 CC CC NNP cord-280642-cvxni7cd 174 2 - - : cord-280642-cvxni7cd 174 3 BY by IN cord-280642-cvxni7cd 174 4 4.0 4.0 CD cord-280642-cvxni7cd 174 5 International international JJ cord-280642-cvxni7cd 174 6 license license NN cord-280642-cvxni7cd 175 1 It -PRON- PRP cord-280642-cvxni7cd 175 2 is be VBZ cord-280642-cvxni7cd 175 3 made make VBN cord-280642-cvxni7cd 175 4 available available JJ cord-280642-cvxni7cd 175 5 under under IN cord-280642-cvxni7cd 175 6 a a DT cord-280642-cvxni7cd 176 1 is be VBZ cord-280642-cvxni7cd 176 2 the the DT cord-280642-cvxni7cd 176 3 author author NN cord-280642-cvxni7cd 176 4 / / SYM cord-280642-cvxni7cd 176 5 funder funder NN cord-280642-cvxni7cd 176 6 , , , cord-280642-cvxni7cd 176 7 who who WP cord-280642-cvxni7cd 176 8 has have VBZ cord-280642-cvxni7cd 176 9 granted grant VBN cord-280642-cvxni7cd 176 10 medRxiv medRxiv NNS cord-280642-cvxni7cd 176 11 a a DT cord-280642-cvxni7cd 176 12 license license NN cord-280642-cvxni7cd 176 13 to to TO cord-280642-cvxni7cd 176 14 display display VB cord-280642-cvxni7cd 176 15 the the DT cord-280642-cvxni7cd 176 16 preprint preprint NN cord-280642-cvxni7cd 176 17 in in IN cord-280642-cvxni7cd 176 18 perpetuity perpetuity NN cord-280642-cvxni7cd 176 19 . . . cord-280642-cvxni7cd 177 1 The the DT cord-280642-cvxni7cd 177 2 copyright copyright NN cord-280642-cvxni7cd 177 3 holder holder NN cord-280642-cvxni7cd 177 4 for for IN cord-280642-cvxni7cd 177 5 this this DT cord-280642-cvxni7cd 177 6 preprint preprint NN cord-280642-cvxni7cd 177 7 this this DT cord-280642-cvxni7cd 177 8 version version NN cord-280642-cvxni7cd 177 9 posted post VBN cord-280642-cvxni7cd 177 10 May May NNP cord-280642-cvxni7cd 177 11 7 7 CD cord-280642-cvxni7cd 177 12 , , , cord-280642-cvxni7cd 177 13 2020 2020 CD cord-280642-cvxni7cd 177 14 . . . cord-280642-cvxni7cd 177 15 . . . cord-280642-cvxni7cd 178 1 CC CC NNP cord-280642-cvxni7cd 178 2 - - : cord-280642-cvxni7cd 178 3 BY by IN cord-280642-cvxni7cd 178 4 4.0 4.0 CD cord-280642-cvxni7cd 178 5 International international JJ cord-280642-cvxni7cd 178 6 license license NN cord-280642-cvxni7cd 179 1 It -PRON- PRP cord-280642-cvxni7cd 179 2 is be VBZ cord-280642-cvxni7cd 179 3 made make VBN cord-280642-cvxni7cd 179 4 available available JJ cord-280642-cvxni7cd 179 5 under under IN cord-280642-cvxni7cd 179 6 a a DT cord-280642-cvxni7cd 180 1 is be VBZ cord-280642-cvxni7cd 180 2 the the DT cord-280642-cvxni7cd 180 3 author author NN cord-280642-cvxni7cd 180 4 / / SYM cord-280642-cvxni7cd 180 5 funder funder NN cord-280642-cvxni7cd 180 6 , , , cord-280642-cvxni7cd 180 7 who who WP cord-280642-cvxni7cd 180 8 has have VBZ cord-280642-cvxni7cd 180 9 granted grant VBN cord-280642-cvxni7cd 180 10 medRxiv medRxiv NNS cord-280642-cvxni7cd 180 11 a a DT cord-280642-cvxni7cd 180 12 license license NN cord-280642-cvxni7cd 180 13 to to TO cord-280642-cvxni7cd 180 14 display display VB cord-280642-cvxni7cd 180 15 the the DT cord-280642-cvxni7cd 180 16 preprint preprint NN cord-280642-cvxni7cd 180 17 in in IN cord-280642-cvxni7cd 180 18 perpetuity perpetuity NN cord-280642-cvxni7cd 180 19 . . . cord-280642-cvxni7cd 181 1 The the DT cord-280642-cvxni7cd 181 2 copyright copyright NN cord-280642-cvxni7cd 181 3 holder holder NN cord-280642-cvxni7cd 181 4 for for IN cord-280642-cvxni7cd 181 5 this this DT cord-280642-cvxni7cd 181 6 preprint preprint NN cord-280642-cvxni7cd 181 7 this this DT cord-280642-cvxni7cd 181 8 version version NN cord-280642-cvxni7cd 181 9 posted post VBN cord-280642-cvxni7cd 181 10 May May NNP cord-280642-cvxni7cd 181 11 7 7 CD cord-280642-cvxni7cd 181 12 , , , cord-280642-cvxni7cd 181 13 2020 2020 CD cord-280642-cvxni7cd 181 14 . . . cord-280642-cvxni7cd 181 15 . . . cord-280642-cvxni7cd 182 1 CC CC NNP cord-280642-cvxni7cd 182 2 - - : cord-280642-cvxni7cd 182 3 BY by IN cord-280642-cvxni7cd 182 4 4.0 4.0 CD cord-280642-cvxni7cd 182 5 International international JJ cord-280642-cvxni7cd 182 6 license license NN cord-280642-cvxni7cd 183 1 It -PRON- PRP cord-280642-cvxni7cd 183 2 is be VBZ cord-280642-cvxni7cd 183 3 made make VBN cord-280642-cvxni7cd 183 4 available available JJ cord-280642-cvxni7cd 183 5 under under IN cord-280642-cvxni7cd 183 6 a a DT cord-280642-cvxni7cd 184 1 is be VBZ cord-280642-cvxni7cd 184 2 the the DT cord-280642-cvxni7cd 184 3 author author NN cord-280642-cvxni7cd 184 4 / / SYM cord-280642-cvxni7cd 184 5 funder funder NN cord-280642-cvxni7cd 184 6 , , , cord-280642-cvxni7cd 184 7 who who WP cord-280642-cvxni7cd 184 8 has have VBZ cord-280642-cvxni7cd 184 9 granted grant VBN cord-280642-cvxni7cd 184 10 medRxiv medRxiv NNS cord-280642-cvxni7cd 184 11 a a DT cord-280642-cvxni7cd 184 12 license license NN cord-280642-cvxni7cd 184 13 to to TO cord-280642-cvxni7cd 184 14 display display VB cord-280642-cvxni7cd 184 15 the the DT cord-280642-cvxni7cd 184 16 preprint preprint NN cord-280642-cvxni7cd 184 17 in in IN cord-280642-cvxni7cd 184 18 perpetuity perpetuity NN cord-280642-cvxni7cd 184 19 . . . cord-280642-cvxni7cd 185 1 The the DT cord-280642-cvxni7cd 185 2 copyright copyright NN cord-280642-cvxni7cd 185 3 holder holder NN cord-280642-cvxni7cd 185 4 for for IN cord-280642-cvxni7cd 185 5 this this DT cord-280642-cvxni7cd 185 6 preprint preprint NN cord-280642-cvxni7cd 185 7 this this DT cord-280642-cvxni7cd 185 8 version version NN cord-280642-cvxni7cd 185 9 posted post VBN cord-280642-cvxni7cd 185 10 May May NNP cord-280642-cvxni7cd 185 11 7 7 CD cord-280642-cvxni7cd 185 12 , , , cord-280642-cvxni7cd 185 13 2020 2020 CD cord-280642-cvxni7cd 185 14 . . . cord-280642-cvxni7cd 185 15 . . . cord-280642-cvxni7cd 186 1 CC CC NNP cord-280642-cvxni7cd 186 2 - - : cord-280642-cvxni7cd 186 3 BY by IN cord-280642-cvxni7cd 186 4 4.0 4.0 CD cord-280642-cvxni7cd 186 5 International international JJ cord-280642-cvxni7cd 186 6 license license NN cord-280642-cvxni7cd 187 1 It -PRON- PRP cord-280642-cvxni7cd 187 2 is be VBZ cord-280642-cvxni7cd 187 3 made make VBN cord-280642-cvxni7cd 187 4 available available JJ cord-280642-cvxni7cd 187 5 under under IN cord-280642-cvxni7cd 187 6 a a DT cord-280642-cvxni7cd 188 1 is be VBZ cord-280642-cvxni7cd 188 2 the the DT cord-280642-cvxni7cd 188 3 author author NN cord-280642-cvxni7cd 188 4 / / SYM cord-280642-cvxni7cd 188 5 funder funder NN cord-280642-cvxni7cd 188 6 , , , cord-280642-cvxni7cd 188 7 who who WP cord-280642-cvxni7cd 188 8 has have VBZ cord-280642-cvxni7cd 188 9 granted grant VBN cord-280642-cvxni7cd 188 10 medRxiv medRxiv NNS cord-280642-cvxni7cd 188 11 a a DT cord-280642-cvxni7cd 188 12 license license NN cord-280642-cvxni7cd 188 13 to to TO cord-280642-cvxni7cd 188 14 display display VB cord-280642-cvxni7cd 188 15 the the DT cord-280642-cvxni7cd 188 16 preprint preprint NN cord-280642-cvxni7cd 188 17 in in IN cord-280642-cvxni7cd 188 18 perpetuity perpetuity NN cord-280642-cvxni7cd 188 19 . . . cord-280642-cvxni7cd 189 1 The the DT cord-280642-cvxni7cd 189 2 copyright copyright NN cord-280642-cvxni7cd 189 3 holder holder NN cord-280642-cvxni7cd 189 4 for for IN cord-280642-cvxni7cd 189 5 this this DT cord-280642-cvxni7cd 189 6 preprint preprint NN cord-280642-cvxni7cd 189 7 this this DT cord-280642-cvxni7cd 189 8 version version NN cord-280642-cvxni7cd 189 9 posted post VBN cord-280642-cvxni7cd 189 10 May May NNP cord-280642-cvxni7cd 189 11 7 7 CD cord-280642-cvxni7cd 189 12 , , , cord-280642-cvxni7cd 189 13 2020 2020 CD cord-280642-cvxni7cd 189 14 . . . cord-280642-cvxni7cd 190 1 Most Most JJS cord-280642-cvxni7cd 190 2 comorbidities comorbiditie NNS cord-280642-cvxni7cd 190 3 were be VBD cord-280642-cvxni7cd 190 4 associated associate VBN cord-280642-cvxni7cd 190 5 with with IN cord-280642-cvxni7cd 190 6 higher high JJR cord-280642-cvxni7cd 190 7 risk risk NN cord-280642-cvxni7cd 190 8 of of IN cord-280642-cvxni7cd 190 9 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 190 10 hospital hospital NN cord-280642-cvxni7cd 190 11 death death NN cord-280642-cvxni7cd 190 12 , , , cord-280642-cvxni7cd 190 13 including include VBG cord-280642-cvxni7cd 190 14 diabetes diabetes NN cord-280642-cvxni7cd 190 15 ( ( -LRB- cord-280642-cvxni7cd 190 16 with with IN cord-280642-cvxni7cd 190 17 a a DT cord-280642-cvxni7cd 190 18 greater great JJR cord-280642-cvxni7cd 190 19 HR hr NN cord-280642-cvxni7cd 190 20 for for IN cord-280642-cvxni7cd 190 21 those those DT cord-280642-cvxni7cd 190 22 with with IN cord-280642-cvxni7cd 190 23 recent recent JJ cord-280642-cvxni7cd 190 24 HbA1c hba1c NN cord-280642-cvxni7cd 191 1 > > XX cord-280642-cvxni7cd 191 2 = = SYM cord-280642-cvxni7cd 191 3 58 58 CD cord-280642-cvxni7cd 191 4 mmol mmol JJ cord-280642-cvxni7cd 191 5 / / SYM cord-280642-cvxni7cd 191 6 mol mol NN cord-280642-cvxni7cd 191 7 ) ) -RRB- cord-280642-cvxni7cd 191 8 , , . cord-280642-cvxni7cd 192 1 asthma asthma NNP cord-280642-cvxni7cd 192 2 ( ( -LRB- cord-280642-cvxni7cd 192 3 with with IN cord-280642-cvxni7cd 192 4 a a DT cord-280642-cvxni7cd 192 5 greater great JJR cord-280642-cvxni7cd 192 6 HR hr NN cord-280642-cvxni7cd 192 7 for for IN cord-280642-cvxni7cd 192 8 those those DT cord-280642-cvxni7cd 192 9 with with IN cord-280642-cvxni7cd 192 10 recent recent JJ cord-280642-cvxni7cd 192 11 use use NN cord-280642-cvxni7cd 192 12 of of IN cord-280642-cvxni7cd 192 13 an an DT cord-280642-cvxni7cd 192 14 oral oral JJ cord-280642-cvxni7cd 192 15 corticosteroid corticosteroid NN cord-280642-cvxni7cd 192 16 ) ) -RRB- cord-280642-cvxni7cd 192 17 , , , cord-280642-cvxni7cd 192 18 respiratory respiratory JJ cord-280642-cvxni7cd 192 19 disease disease NN cord-280642-cvxni7cd 192 20 , , , cord-280642-cvxni7cd 192 21 chronic chronic JJ cord-280642-cvxni7cd 192 22 heart heart NN cord-280642-cvxni7cd 192 23 disease disease NN cord-280642-cvxni7cd 192 24 , , , cord-280642-cvxni7cd 192 25 liver liver NN cord-280642-cvxni7cd 192 26 disease disease NN cord-280642-cvxni7cd 192 27 , , , cord-280642-cvxni7cd 192 28 stroke stroke NN cord-280642-cvxni7cd 192 29 / / SYM cord-280642-cvxni7cd 192 30 dementia dementia NN cord-280642-cvxni7cd 192 31 , , , cord-280642-cvxni7cd 192 32 other other JJ cord-280642-cvxni7cd 192 33 neurological neurological JJ cord-280642-cvxni7cd 192 34 diseases disease NNS cord-280642-cvxni7cd 192 35 , , , cord-280642-cvxni7cd 192 36 reduced reduce VBN cord-280642-cvxni7cd 192 37 kidney kidney NN cord-280642-cvxni7cd 192 38 function function NN cord-280642-cvxni7cd 192 39 , , , cord-280642-cvxni7cd 192 40 autoimmune autoimmune JJ cord-280642-cvxni7cd 192 41 diseases disease NNS cord-280642-cvxni7cd 192 42 ( ( -LRB- cord-280642-cvxni7cd 192 43 rheumatoid rheumatoid JJ cord-280642-cvxni7cd 192 44 arthritis arthritis NN cord-280642-cvxni7cd 192 45 , , , cord-280642-cvxni7cd 192 46 lupus lupus NN cord-280642-cvxni7cd 192 47 or or CC cord-280642-cvxni7cd 192 48 psoriasis psoriasis NN cord-280642-cvxni7cd 192 49 ) ) -RRB- cord-280642-cvxni7cd 192 50 and and CC cord-280642-cvxni7cd 192 51 other other JJ cord-280642-cvxni7cd 192 52 immunosuppressive immunosuppressive JJ cord-280642-cvxni7cd 192 53 conditions condition NNS cord-280642-cvxni7cd 192 54 , , , cord-280642-cvxni7cd 192 55 as as IN cord-280642-cvxni7cd 192 56 per per IN cord-280642-cvxni7cd 192 57 Table table NN cord-280642-cvxni7cd 192 58 2 2 CD cord-280642-cvxni7cd 192 59 . . . cord-280642-cvxni7cd 193 1 Those those DT cord-280642-cvxni7cd 193 2 with with IN cord-280642-cvxni7cd 193 3 a a DT cord-280642-cvxni7cd 193 4 history history NN cord-280642-cvxni7cd 193 5 of of IN cord-280642-cvxni7cd 193 6 haematological haematological JJ cord-280642-cvxni7cd 193 7 malignancy malignancy NN cord-280642-cvxni7cd 193 8 were be VBD cord-280642-cvxni7cd 193 9 at at IN cord-280642-cvxni7cd 193 10 > > XX cord-280642-cvxni7cd 193 11 3-fold 3-fold CD cord-280642-cvxni7cd 193 12 increased increase VBN cord-280642-cvxni7cd 193 13 risk risk NN cord-280642-cvxni7cd 193 14 up up IN cord-280642-cvxni7cd 193 15 to to TO cord-280642-cvxni7cd 193 16 5 5 CD cord-280642-cvxni7cd 193 17 years year NNS cord-280642-cvxni7cd 193 18 from from IN cord-280642-cvxni7cd 193 19 diagnosis diagnosis NN cord-280642-cvxni7cd 193 20 , , , cord-280642-cvxni7cd 193 21 and and CC cord-280642-cvxni7cd 193 22 nearly nearly RB cord-280642-cvxni7cd 193 23 double double PDT cord-280642-cvxni7cd 193 24 the the DT cord-280642-cvxni7cd 193 25 risk risk NN cord-280642-cvxni7cd 193 26 thereafter thereafter RB cord-280642-cvxni7cd 193 27 . . . cord-280642-cvxni7cd 194 1 For for IN cord-280642-cvxni7cd 194 2 other other JJ cord-280642-cvxni7cd 194 3 cancers cancer NNS cord-280642-cvxni7cd 194 4 , , , cord-280642-cvxni7cd 194 5 HRs hr NNS cord-280642-cvxni7cd 194 6 were be VBD cord-280642-cvxni7cd 194 7 smaller small JJR cord-280642-cvxni7cd 194 8 and and CC cord-280642-cvxni7cd 194 9 risk risk NN cord-280642-cvxni7cd 194 10 increases increase NNS cord-280642-cvxni7cd 194 11 were be VBD cord-280642-cvxni7cd 194 12 largely largely RB cord-280642-cvxni7cd 194 13 observed observed JJ cord-280642-cvxni7cd 194 14 among among IN cord-280642-cvxni7cd 194 15 those those DT cord-280642-cvxni7cd 194 16 diagnosed diagnose VBN cord-280642-cvxni7cd 194 17 in in IN cord-280642-cvxni7cd 194 18 the the DT cord-280642-cvxni7cd 194 19 last last JJ cord-280642-cvxni7cd 194 20 year year NN cord-280642-cvxni7cd 194 21 . . . cord-280642-cvxni7cd 195 1 There there EX cord-280642-cvxni7cd 195 2 was be VBD cord-280642-cvxni7cd 195 3 no no DT cord-280642-cvxni7cd 195 4 association association NN cord-280642-cvxni7cd 195 5 between between IN cord-280642-cvxni7cd 195 6 hypertension hypertension NN cord-280642-cvxni7cd 195 7 ( ( -LRB- cord-280642-cvxni7cd 195 8 defined define VBN cord-280642-cvxni7cd 195 9 as as IN cord-280642-cvxni7cd 195 10 a a DT cord-280642-cvxni7cd 195 11 recorded record VBN cord-280642-cvxni7cd 195 12 diagnosis diagnosis NN cord-280642-cvxni7cd 195 13 , , , cord-280642-cvxni7cd 195 14 or or CC cord-280642-cvxni7cd 195 15 high high JJ cord-280642-cvxni7cd 195 16 blood blood NN cord-280642-cvxni7cd 195 17 pressure pressure NN cord-280642-cvxni7cd 195 18 at at IN cord-280642-cvxni7cd 195 19 the the DT cord-280642-cvxni7cd 195 20 last last JJ cord-280642-cvxni7cd 195 21 measurement measurement NN cord-280642-cvxni7cd 195 22 ) ) -RRB- cord-280642-cvxni7cd 195 23 and and CC cord-280642-cvxni7cd 195 24 outcome outcome NN cord-280642-cvxni7cd 195 25 ( ( -LRB- cord-280642-cvxni7cd 195 26 HR HR NNP cord-280642-cvxni7cd 195 27 0.95 0.95 CD cord-280642-cvxni7cd 195 28 , , , cord-280642-cvxni7cd 195 29 0.89 0.89 CD cord-280642-cvxni7cd 195 30 - - SYM cord-280642-cvxni7cd 195 31 1.01 1.01 CD cord-280642-cvxni7cd 195 32 ) ) -RRB- cord-280642-cvxni7cd 195 33 . . . cord-280642-cvxni7cd 196 1 However however RB cord-280642-cvxni7cd 196 2 , , , cord-280642-cvxni7cd 196 3 in in IN cord-280642-cvxni7cd 196 4 sensitivity sensitivity NN cord-280642-cvxni7cd 196 5 analyses analysis NNS cord-280642-cvxni7cd 196 6 , , , cord-280642-cvxni7cd 196 7 diagnosed diagnosed JJ cord-280642-cvxni7cd 196 8 hypertension hypertension NN cord-280642-cvxni7cd 196 9 was be VBD cord-280642-cvxni7cd 196 10 associated associate VBN cord-280642-cvxni7cd 196 11 with with IN cord-280642-cvxni7cd 196 12 slightly slightly RB cord-280642-cvxni7cd 196 13 increased increase VBN cord-280642-cvxni7cd 196 14 risk risk NN cord-280642-cvxni7cd 196 15 ( ( -LRB- cord-280642-cvxni7cd 196 16 HR HR NNP cord-280642-cvxni7cd 196 17 1.07 1.07 CD cord-280642-cvxni7cd 196 18 , , , cord-280642-cvxni7cd 196 19 1.00 1.00 CD cord-280642-cvxni7cd 196 20 - - SYM cord-280642-cvxni7cd 196 21 1.15 1.15 CD cord-280642-cvxni7cd 196 22 ) ) -RRB- cord-280642-cvxni7cd 196 23 while while IN cord-280642-cvxni7cd 196 24 high high JJ cord-280642-cvxni7cd 196 25 blood blood NN cord-280642-cvxni7cd 196 26 pressure pressure NN cord-280642-cvxni7cd 196 27 ( ( -LRB- cord-280642-cvxni7cd 196 28 ≥140/90 ≥140/90 NN cord-280642-cvxni7cd 196 29 mmHg mmHg NNP cord-280642-cvxni7cd 196 30 ) ) -RRB- cord-280642-cvxni7cd 196 31 at at IN cord-280642-cvxni7cd 196 32 the the DT cord-280642-cvxni7cd 196 33 most most RBS cord-280642-cvxni7cd 196 34 recent recent JJ cord-280642-cvxni7cd 196 35 measurement measurement NN cord-280642-cvxni7cd 196 36 was be VBD cord-280642-cvxni7cd 196 37 associated associate VBN cord-280642-cvxni7cd 196 38 with with IN cord-280642-cvxni7cd 196 39 lower low JJR cord-280642-cvxni7cd 196 40 risk risk NN cord-280642-cvxni7cd 196 41 ( ( -LRB- cord-280642-cvxni7cd 196 42 HR HR NNP cord-280642-cvxni7cd 196 43 0.61 0.61 CD cord-280642-cvxni7cd 196 44 , , , cord-280642-cvxni7cd 196 45 0.56 0.56 CD cord-280642-cvxni7cd 196 46 - - SYM cord-280642-cvxni7cd 196 47 0.67 0.67 CD cord-280642-cvxni7cd 196 48 ) ) -RRB- cord-280642-cvxni7cd 196 49 . . . cord-280642-cvxni7cd 196 50 . . . cord-280642-cvxni7cd 197 1 CC CC NNP cord-280642-cvxni7cd 197 2 - - : cord-280642-cvxni7cd 197 3 BY by IN cord-280642-cvxni7cd 197 4 4.0 4.0 CD cord-280642-cvxni7cd 197 5 International international JJ cord-280642-cvxni7cd 197 6 license license NN cord-280642-cvxni7cd 198 1 It -PRON- PRP cord-280642-cvxni7cd 198 2 is be VBZ cord-280642-cvxni7cd 198 3 made make VBN cord-280642-cvxni7cd 198 4 available available JJ cord-280642-cvxni7cd 198 5 under under IN cord-280642-cvxni7cd 198 6 a a DT cord-280642-cvxni7cd 199 1 is be VBZ cord-280642-cvxni7cd 199 2 the the DT cord-280642-cvxni7cd 199 3 author author NN cord-280642-cvxni7cd 199 4 / / SYM cord-280642-cvxni7cd 199 5 funder funder NN cord-280642-cvxni7cd 199 6 , , , cord-280642-cvxni7cd 199 7 who who WP cord-280642-cvxni7cd 199 8 has have VBZ cord-280642-cvxni7cd 199 9 granted grant VBN cord-280642-cvxni7cd 199 10 medRxiv medRxiv NNS cord-280642-cvxni7cd 199 11 a a DT cord-280642-cvxni7cd 199 12 license license NN cord-280642-cvxni7cd 199 13 to to TO cord-280642-cvxni7cd 199 14 display display VB cord-280642-cvxni7cd 199 15 the the DT cord-280642-cvxni7cd 199 16 preprint preprint NN cord-280642-cvxni7cd 199 17 in in IN cord-280642-cvxni7cd 199 18 perpetuity perpetuity NN cord-280642-cvxni7cd 199 19 . . . cord-280642-cvxni7cd 200 1 The the DT cord-280642-cvxni7cd 200 2 copyright copyright NN cord-280642-cvxni7cd 200 3 holder holder NN cord-280642-cvxni7cd 200 4 for for IN cord-280642-cvxni7cd 200 5 this this DT cord-280642-cvxni7cd 200 6 preprint preprint NN cord-280642-cvxni7cd 200 7 this this DT cord-280642-cvxni7cd 200 8 version version NN cord-280642-cvxni7cd 200 9 posted post VBN cord-280642-cvxni7cd 200 10 May May NNP cord-280642-cvxni7cd 200 11 7 7 CD cord-280642-cvxni7cd 200 12 , , , cord-280642-cvxni7cd 200 13 2020 2020 CD cord-280642-cvxni7cd 200 14 . . . cord-280642-cvxni7cd 201 1 is be VBZ cord-280642-cvxni7cd 201 2 the the DT cord-280642-cvxni7cd 201 3 author author NN cord-280642-cvxni7cd 201 4 / / SYM cord-280642-cvxni7cd 201 5 funder funder NN cord-280642-cvxni7cd 201 6 , , , cord-280642-cvxni7cd 201 7 who who WP cord-280642-cvxni7cd 201 8 has have VBZ cord-280642-cvxni7cd 201 9 granted grant VBN cord-280642-cvxni7cd 201 10 medRxiv medRxiv NNS cord-280642-cvxni7cd 201 11 a a DT cord-280642-cvxni7cd 201 12 license license NN cord-280642-cvxni7cd 201 13 to to TO cord-280642-cvxni7cd 201 14 display display VB cord-280642-cvxni7cd 201 15 the the DT cord-280642-cvxni7cd 201 16 preprint preprint NN cord-280642-cvxni7cd 201 17 in in IN cord-280642-cvxni7cd 201 18 perpetuity perpetuity NN cord-280642-cvxni7cd 201 19 . . . cord-280642-cvxni7cd 202 1 The the DT cord-280642-cvxni7cd 202 2 copyright copyright NN cord-280642-cvxni7cd 202 3 holder holder NN cord-280642-cvxni7cd 202 4 for for IN cord-280642-cvxni7cd 202 5 this this DT cord-280642-cvxni7cd 202 6 preprint preprint NN cord-280642-cvxni7cd 202 7 this this DT cord-280642-cvxni7cd 202 8 version version NN cord-280642-cvxni7cd 202 9 posted post VBN cord-280642-cvxni7cd 202 10 May May NNP cord-280642-cvxni7cd 202 11 7 7 CD cord-280642-cvxni7cd 202 12 , , , cord-280642-cvxni7cd 202 13 2020 2020 CD cord-280642-cvxni7cd 202 14 . . . cord-280642-cvxni7cd 203 1 The the DT cord-280642-cvxni7cd 203 2 average average JJ cord-280642-cvxni7cd 203 3 C c NN cord-280642-cvxni7cd 203 4 - - HYPH cord-280642-cvxni7cd 203 5 statistic statistic NN cord-280642-cvxni7cd 203 6 was be VBD cord-280642-cvxni7cd 203 7 0.78 0.78 CD cord-280642-cvxni7cd 203 8 . . . cord-280642-cvxni7cd 204 1 Sensitivity sensitivity NN cord-280642-cvxni7cd 204 2 analyses analysis NNS cord-280642-cvxni7cd 204 3 are be VBP cord-280642-cvxni7cd 204 4 shown show VBN cord-280642-cvxni7cd 204 5 in in IN cord-280642-cvxni7cd 204 6 Table Table NNP cord-280642-cvxni7cd 204 7 A1 A1 NNP cord-280642-cvxni7cd 204 8 ( ( -LRB- cord-280642-cvxni7cd 204 9 appendix appendix NNP cord-280642-cvxni7cd 204 10 ) ) -RRB- cord-280642-cvxni7cd 204 11 . . . cord-280642-cvxni7cd 205 1 Results result NNS cord-280642-cvxni7cd 205 2 were be VBD cord-280642-cvxni7cd 205 3 similar similar JJ cord-280642-cvxni7cd 205 4 when when WRB cord-280642-cvxni7cd 205 5 restricted restrict VBN cord-280642-cvxni7cd 205 6 to to IN cord-280642-cvxni7cd 205 7 those those DT cord-280642-cvxni7cd 205 8 with with IN cord-280642-cvxni7cd 205 9 complete complete JJ cord-280642-cvxni7cd 205 10 BMI bmi NN cord-280642-cvxni7cd 205 11 and and CC cord-280642-cvxni7cd 205 12 smoking smoking NN cord-280642-cvxni7cd 205 13 information information NN cord-280642-cvxni7cd 205 14 , , , cord-280642-cvxni7cd 205 15 and and CC cord-280642-cvxni7cd 205 16 when when WRB cord-280642-cvxni7cd 205 17 adjusted adjust VBN cord-280642-cvxni7cd 205 18 for for IN cord-280642-cvxni7cd 205 19 ethnicity ethnicity NN cord-280642-cvxni7cd 205 20 , , , cord-280642-cvxni7cd 205 21 among among IN cord-280642-cvxni7cd 205 22 those those DT cord-280642-cvxni7cd 205 23 with with IN cord-280642-cvxni7cd 205 24 complete complete JJ cord-280642-cvxni7cd 205 25 data datum NNS cord-280642-cvxni7cd 205 26 . . . cord-280642-cvxni7cd 206 1 Violation violation NN cord-280642-cvxni7cd 206 2 of of IN cord-280642-cvxni7cd 206 3 proportional proportional JJ cord-280642-cvxni7cd 206 4 hazards hazard NNS cord-280642-cvxni7cd 206 5 was be VBD cord-280642-cvxni7cd 206 6 detected detect VBN cord-280642-cvxni7cd 206 7 in in IN cord-280642-cvxni7cd 206 8 the the DT cord-280642-cvxni7cd 206 9 primary primary JJ cord-280642-cvxni7cd 206 10 model model NN cord-280642-cvxni7cd 206 11 ( ( -LRB- cord-280642-cvxni7cd 206 12 p<0.001 p<0.001 JJ cord-280642-cvxni7cd 206 13 ) ) -RRB- cord-280642-cvxni7cd 206 14 , , , cord-280642-cvxni7cd 206 15 so so IN cord-280642-cvxni7cd 206 16 a a DT cord-280642-cvxni7cd 206 17 further further JJ cord-280642-cvxni7cd 206 18 sensitivity sensitivity NN cord-280642-cvxni7cd 206 19 analysis analysis NN cord-280642-cvxni7cd 206 20 was be VBD cord-280642-cvxni7cd 206 21 run run VBN cord-280642-cvxni7cd 206 22 with with IN cord-280642-cvxni7cd 206 23 earlier early JJR cord-280642-cvxni7cd 206 24 administrative administrative JJ cord-280642-cvxni7cd 206 25 censoring censoring NN cord-280642-cvxni7cd 206 26 at at IN cord-280642-cvxni7cd 206 27 6th 6th JJ cord-280642-cvxni7cd 206 28 April April NNP cord-280642-cvxni7cd 206 29 2020 2020 CD cord-280642-cvxni7cd 206 30 , , , cord-280642-cvxni7cd 206 31 since since IN cord-280642-cvxni7cd 206 32 social social JJ cord-280642-cvxni7cd 206 33 distancing distance VBG cord-280642-cvxni7cd 206 34 measures measure NNS cord-280642-cvxni7cd 206 35 introduced introduce VBN cord-280642-cvxni7cd 206 36 across across IN cord-280642-cvxni7cd 206 37 the the DT cord-280642-cvxni7cd 206 38 UK UK NNP cord-280642-cvxni7cd 206 39 in in IN cord-280642-cvxni7cd 206 40 late late JJ cord-280642-cvxni7cd 206 41 March March NNP cord-280642-cvxni7cd 206 42 2020 2020 CD cord-280642-cvxni7cd 206 43 would would MD cord-280642-cvxni7cd 206 44 not not RB cord-280642-cvxni7cd 206 45 have have VB cord-280642-cvxni7cd 206 46 been be VBN cord-280642-cvxni7cd 206 47 expected expect VBN cord-280642-cvxni7cd 206 48 to to TO cord-280642-cvxni7cd 206 49 impact impact VB cord-280642-cvxni7cd 206 50 on on IN cord-280642-cvxni7cd 206 51 mortality mortality NN cord-280642-cvxni7cd 206 52 rates rate NNS cord-280642-cvxni7cd 206 53 at at IN cord-280642-cvxni7cd 206 54 that that DT cord-280642-cvxni7cd 206 55 time time NN cord-280642-cvxni7cd 206 56 . . . cord-280642-cvxni7cd 207 1 There there EX cord-280642-cvxni7cd 207 2 was be VBD cord-280642-cvxni7cd 207 3 no no DT cord-280642-cvxni7cd 207 4 evidence evidence NN cord-280642-cvxni7cd 207 5 of of IN cord-280642-cvxni7cd 207 6 non non JJ cord-280642-cvxni7cd 207 7 - - JJ cord-280642-cvxni7cd 207 8 proportional proportional JJ cord-280642-cvxni7cd 207 9 hazards hazard NNS cord-280642-cvxni7cd 207 10 in in IN cord-280642-cvxni7cd 207 11 this this DT cord-280642-cvxni7cd 207 12 analysis analysis NN cord-280642-cvxni7cd 207 13 ( ( -LRB- cord-280642-cvxni7cd 207 14 p=0.56 p=0.56 NNP cord-280642-cvxni7cd 207 15 ) ) -RRB- cord-280642-cvxni7cd 207 16 . . . cord-280642-cvxni7cd 208 1 The the DT cord-280642-cvxni7cd 208 2 overall overall JJ cord-280642-cvxni7cd 208 3 pattern pattern NN cord-280642-cvxni7cd 208 4 of of IN cord-280642-cvxni7cd 208 5 results result NNS cord-280642-cvxni7cd 208 6 was be VBD cord-280642-cvxni7cd 208 7 similar similar JJ cord-280642-cvxni7cd 208 8 to to IN cord-280642-cvxni7cd 208 9 the the DT cord-280642-cvxni7cd 208 10 primary primary JJ cord-280642-cvxni7cd 208 11 model model NN cord-280642-cvxni7cd 208 12 , , , cord-280642-cvxni7cd 208 13 though though IN cord-280642-cvxni7cd 208 14 most most JJS cord-280642-cvxni7cd 208 15 HRs hr NNS cord-280642-cvxni7cd 208 16 were be VBD cord-280642-cvxni7cd 208 17 somewhat somewhat RB cord-280642-cvxni7cd 208 18 larger large JJR cord-280642-cvxni7cd 208 19 in in IN cord-280642-cvxni7cd 208 20 magnitude magnitude NN cord-280642-cvxni7cd 208 21 in in IN cord-280642-cvxni7cd 208 22 the the DT cord-280642-cvxni7cd 208 23 analysis analysis NN cord-280642-cvxni7cd 208 24 restricted restrict VBN cord-280642-cvxni7cd 208 25 to to IN cord-280642-cvxni7cd 208 26 this this DT cord-280642-cvxni7cd 208 27 earlier early JJR cord-280642-cvxni7cd 208 28 period period NN cord-280642-cvxni7cd 208 29 , , , cord-280642-cvxni7cd 208 30 while while IN cord-280642-cvxni7cd 208 31 the the DT cord-280642-cvxni7cd 208 32 effect effect NN cord-280642-cvxni7cd 208 33 of of IN cord-280642-cvxni7cd 208 34 increasing increase VBG cord-280642-cvxni7cd 208 35 deprivation deprivation NN cord-280642-cvxni7cd 208 36 appeared appear VBD cord-280642-cvxni7cd 208 37 to to TO cord-280642-cvxni7cd 208 38 be be VB cord-280642-cvxni7cd 208 39 smaller small JJR cord-280642-cvxni7cd 208 40 ( ( -LRB- cord-280642-cvxni7cd 208 41 appendix appendix NN cord-280642-cvxni7cd 208 42 Table table NN cord-280642-cvxni7cd 208 43 _SP cord-280642-cvxni7cd 208 44 A1 A1 NNP cord-280642-cvxni7cd 208 45 ) ) -RRB- cord-280642-cvxni7cd 208 46 . . . cord-280642-cvxni7cd 209 1 We -PRON- PRP cord-280642-cvxni7cd 209 2 have have VBP cord-280642-cvxni7cd 209 3 successfully successfully RB cord-280642-cvxni7cd 209 4 delivered deliver VBN cord-280642-cvxni7cd 209 5 a a DT cord-280642-cvxni7cd 209 6 secure secure JJ cord-280642-cvxni7cd 209 7 analytics analytics NN cord-280642-cvxni7cd 209 8 platform platform NN cord-280642-cvxni7cd 209 9 operating operate VBG cord-280642-cvxni7cd 209 10 across across IN cord-280642-cvxni7cd 209 11 almost almost RB cord-280642-cvxni7cd 209 12 24 24 CD cord-280642-cvxni7cd 209 13 million million CD cord-280642-cvxni7cd 209 14 patient patient JJ cord-280642-cvxni7cd 209 15 records record NNS cord-280642-cvxni7cd 209 16 for for IN cord-280642-cvxni7cd 209 17 the the DT cord-280642-cvxni7cd 209 18 Covid-19 covid-19 NN cord-280642-cvxni7cd 209 19 emergency emergency NN cord-280642-cvxni7cd 209 20 , , , cord-280642-cvxni7cd 209 21 and and CC cord-280642-cvxni7cd 209 22 used use VBD cord-280642-cvxni7cd 209 23 this this DT cord-280642-cvxni7cd 209 24 to to TO cord-280642-cvxni7cd 209 25 identify identify VB cord-280642-cvxni7cd 209 26 , , , cord-280642-cvxni7cd 209 27 quantify quantify VB cord-280642-cvxni7cd 209 28 , , , cord-280642-cvxni7cd 209 29 and and CC cord-280642-cvxni7cd 209 30 further further RB cord-280642-cvxni7cd 209 31 explore explore VB cord-280642-cvxni7cd 209 32 a a DT cord-280642-cvxni7cd 209 33 range range NN cord-280642-cvxni7cd 209 34 of of IN cord-280642-cvxni7cd 209 35 risk risk NN cord-280642-cvxni7cd 209 36 factors factor NNS cord-280642-cvxni7cd 209 37 for for IN cord-280642-cvxni7cd 209 38 death death NN cord-280642-cvxni7cd 209 39 in in IN cord-280642-cvxni7cd 209 40 hospital hospital NN cord-280642-cvxni7cd 209 41 from from IN cord-280642-cvxni7cd 209 42 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 209 43 in in IN cord-280642-cvxni7cd 209 44 the the DT cord-280642-cvxni7cd 209 45 largest large JJS cord-280642-cvxni7cd 209 46 cohort cohort NN cord-280642-cvxni7cd 209 47 study study NN cord-280642-cvxni7cd 209 48 conducted conduct VBN cord-280642-cvxni7cd 209 49 by by IN cord-280642-cvxni7cd 209 50 any any DT cord-280642-cvxni7cd 209 51 country country NN cord-280642-cvxni7cd 209 52 to to IN cord-280642-cvxni7cd 209 53 date date NN cord-280642-cvxni7cd 209 54 . . . cord-280642-cvxni7cd 210 1 Most Most JJS cord-280642-cvxni7cd 210 2 comorbidities comorbiditie NNS cord-280642-cvxni7cd 210 3 we -PRON- PRP cord-280642-cvxni7cd 210 4 studied study VBD cord-280642-cvxni7cd 210 5 were be VBD cord-280642-cvxni7cd 210 6 associated associate VBN cord-280642-cvxni7cd 210 7 with with IN cord-280642-cvxni7cd 210 8 increased increase VBN cord-280642-cvxni7cd 210 9 risk risk NN cord-280642-cvxni7cd 210 10 , , , cord-280642-cvxni7cd 210 11 including include VBG cord-280642-cvxni7cd 210 12 cardiovascular cardiovascular JJ cord-280642-cvxni7cd 210 13 disease disease NN cord-280642-cvxni7cd 210 14 , , , cord-280642-cvxni7cd 210 15 diabetes diabetes NN cord-280642-cvxni7cd 210 16 , , , cord-280642-cvxni7cd 210 17 respiratory respiratory JJ cord-280642-cvxni7cd 210 18 disease disease NN cord-280642-cvxni7cd 210 19 including include VBG cord-280642-cvxni7cd 210 20 asthma asthma NN cord-280642-cvxni7cd 210 21 , , , cord-280642-cvxni7cd 210 22 obesity obesity NN cord-280642-cvxni7cd 210 23 , , , cord-280642-cvxni7cd 210 24 history history NN cord-280642-cvxni7cd 210 25 of of IN cord-280642-cvxni7cd 210 26 haematological haematological JJ cord-280642-cvxni7cd 210 27 malignancy malignancy NN cord-280642-cvxni7cd 210 28 or or CC cord-280642-cvxni7cd 210 29 recent recent JJ cord-280642-cvxni7cd 210 30 other other JJ cord-280642-cvxni7cd 210 31 cancer cancer NN cord-280642-cvxni7cd 210 32 , , , cord-280642-cvxni7cd 210 33 kidney kidney NN cord-280642-cvxni7cd 210 34 , , , cord-280642-cvxni7cd 210 35 liver liver NN cord-280642-cvxni7cd 210 36 , , , cord-280642-cvxni7cd 210 37 neurological neurological JJ cord-280642-cvxni7cd 210 38 and and CC cord-280642-cvxni7cd 210 39 autoimmune autoimmune JJ cord-280642-cvxni7cd 210 40 conditions condition NNS cord-280642-cvxni7cd 210 41 . . . cord-280642-cvxni7cd 211 1 People People NNS cord-280642-cvxni7cd 211 2 from from IN cord-280642-cvxni7cd 211 3 Asian asian JJ cord-280642-cvxni7cd 211 4 and and CC cord-280642-cvxni7cd 211 5 black black JJ cord-280642-cvxni7cd 211 6 groups group NNS cord-280642-cvxni7cd 211 7 had have VBD cord-280642-cvxni7cd 211 8 a a DT cord-280642-cvxni7cd 211 9 substantially substantially RB cord-280642-cvxni7cd 211 10 higher high JJR cord-280642-cvxni7cd 211 11 risk risk NN cord-280642-cvxni7cd 211 12 of of IN cord-280642-cvxni7cd 211 13 death death NN cord-280642-cvxni7cd 211 14 from from IN cord-280642-cvxni7cd 211 15 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 211 16 , , , cord-280642-cvxni7cd 211 17 only only RB cord-280642-cvxni7cd 211 18 partially partially RB cord-280642-cvxni7cd 211 19 attributable attributable JJ cord-280642-cvxni7cd 211 20 to to IN cord-280642-cvxni7cd 211 21 co co NN cord-280642-cvxni7cd 211 22 - - NN cord-280642-cvxni7cd 211 23 morbidity morbidity JJ cord-280642-cvxni7cd 211 24 , , , cord-280642-cvxni7cd 211 25 deprivation deprivation NN cord-280642-cvxni7cd 211 26 or or CC cord-280642-cvxni7cd 211 27 other other JJ cord-280642-cvxni7cd 211 28 risk risk NN cord-280642-cvxni7cd 211 29 factors factor NNS cord-280642-cvxni7cd 211 30 . . . cord-280642-cvxni7cd 212 1 Deprivation deprivation NN cord-280642-cvxni7cd 212 2 is be VBZ cord-280642-cvxni7cd 212 3 also also RB cord-280642-cvxni7cd 212 4 a a DT cord-280642-cvxni7cd 212 5 major major JJ cord-280642-cvxni7cd 212 6 risk risk NN cord-280642-cvxni7cd 212 7 factor factor NN cord-280642-cvxni7cd 212 8 , , , cord-280642-cvxni7cd 212 9 which which WDT cord-280642-cvxni7cd 212 10 was be VBD cord-280642-cvxni7cd 212 11 only only RB cord-280642-cvxni7cd 212 12 partly partly RB cord-280642-cvxni7cd 212 13 attributable attributable JJ cord-280642-cvxni7cd 212 14 to to IN cord-280642-cvxni7cd 212 15 co co NN cord-280642-cvxni7cd 212 16 - - NN cord-280642-cvxni7cd 212 17 morbidity morbidity JJ cord-280642-cvxni7cd 212 18 or or CC cord-280642-cvxni7cd 212 19 other other JJ cord-280642-cvxni7cd 212 20 risk risk NN cord-280642-cvxni7cd 212 21 factors factor NNS cord-280642-cvxni7cd 212 22 . . . cord-280642-cvxni7cd 213 1 The the DT cord-280642-cvxni7cd 213 2 greatest great JJS cord-280642-cvxni7cd 213 3 strengths strength NNS cord-280642-cvxni7cd 213 4 of of IN cord-280642-cvxni7cd 213 5 this this DT cord-280642-cvxni7cd 213 6 study study NN cord-280642-cvxni7cd 213 7 were be VBD cord-280642-cvxni7cd 213 8 speed speed NN cord-280642-cvxni7cd 213 9 and and CC cord-280642-cvxni7cd 213 10 size size NN cord-280642-cvxni7cd 213 11 . . . cord-280642-cvxni7cd 214 1 By by IN cord-280642-cvxni7cd 214 2 building build VBG cord-280642-cvxni7cd 214 3 a a DT cord-280642-cvxni7cd 214 4 secure secure JJ cord-280642-cvxni7cd 214 5 analytics analytic NNS cord-280642-cvxni7cd 214 6 platform platform NN cord-280642-cvxni7cd 214 7 across across IN cord-280642-cvxni7cd 214 8 routinely routinely RB cord-280642-cvxni7cd 214 9 collected collect VBN cord-280642-cvxni7cd 214 10 live live JJ cord-280642-cvxni7cd 214 11 clinical clinical JJ cord-280642-cvxni7cd 214 12 data datum NNS cord-280642-cvxni7cd 214 13 stored store VBN cord-280642-cvxni7cd 214 14 in in IN cord-280642-cvxni7cd 214 15 situ situ NN cord-280642-cvxni7cd 214 16 we -PRON- PRP cord-280642-cvxni7cd 214 17 have have VBP cord-280642-cvxni7cd 214 18 been be VBN cord-280642-cvxni7cd 214 19 able able JJ cord-280642-cvxni7cd 214 20 to to TO cord-280642-cvxni7cd 214 21 produce produce VB cord-280642-cvxni7cd 214 22 timely timely JJ cord-280642-cvxni7cd 214 23 results result NNS cord-280642-cvxni7cd 214 24 from from IN cord-280642-cvxni7cd 214 25 the the DT cord-280642-cvxni7cd 214 26 current current JJ cord-280642-cvxni7cd 214 27 records record NNS cord-280642-cvxni7cd 214 28 of of IN cord-280642-cvxni7cd 214 29 approximately approximately RB cord-280642-cvxni7cd 214 30 40 40 CD cord-280642-cvxni7cd 214 31 % % NN cord-280642-cvxni7cd 214 32 of of IN cord-280642-cvxni7cd 214 33 the the DT cord-280642-cvxni7cd 214 34 English english JJ cord-280642-cvxni7cd 214 35 population population NN cord-280642-cvxni7cd 214 36 in in IN cord-280642-cvxni7cd 214 37 response response NN cord-280642-cvxni7cd 214 38 to to IN cord-280642-cvxni7cd 214 39 a a DT cord-280642-cvxni7cd 214 40 global global JJ cord-280642-cvxni7cd 214 41 health health NN cord-280642-cvxni7cd 214 42 emergency emergency NN cord-280642-cvxni7cd 214 43 . . . cord-280642-cvxni7cd 215 1 This this DT cord-280642-cvxni7cd 215 2 scale scale NN cord-280642-cvxni7cd 215 3 allowed allow VBD cord-280642-cvxni7cd 215 4 us -PRON- PRP cord-280642-cvxni7cd 215 5 to to TO cord-280642-cvxni7cd 215 6 work work VB cord-280642-cvxni7cd 215 7 with with IN cord-280642-cvxni7cd 215 8 more more JJR cord-280642-cvxni7cd 215 9 precision precision NN cord-280642-cvxni7cd 215 10 , , , cord-280642-cvxni7cd 215 11 on on IN cord-280642-cvxni7cd 215 12 rarer rare JJR cord-280642-cvxni7cd 215 13 exposures exposure NNS cord-280642-cvxni7cd 215 14 , , , cord-280642-cvxni7cd 215 15 on on IN cord-280642-cvxni7cd 215 16 multiple multiple JJ cord-280642-cvxni7cd 215 17 risk risk NN cord-280642-cvxni7cd 215 18 factors factor NNS cord-280642-cvxni7cd 215 19 , , , cord-280642-cvxni7cd 215 20 and and CC cord-280642-cvxni7cd 215 21 to to TO cord-280642-cvxni7cd 215 22 detect detect VB cord-280642-cvxni7cd 215 23 important important JJ cord-280642-cvxni7cd 215 24 signals signal NNS cord-280642-cvxni7cd 215 25 as as RB cord-280642-cvxni7cd 215 26 early early RB cord-280642-cvxni7cd 215 27 as as IN cord-280642-cvxni7cd 215 28 possible possible JJ cord-280642-cvxni7cd 215 29 in in IN cord-280642-cvxni7cd 215 30 the the DT cord-280642-cvxni7cd 215 31 course course NN cord-280642-cvxni7cd 215 32 of of IN cord-280642-cvxni7cd 215 33 the the DT cord-280642-cvxni7cd 215 34 pandemic pandemic NN cord-280642-cvxni7cd 215 35 . . . cord-280642-cvxni7cd 216 1 The the DT cord-280642-cvxni7cd 216 2 scale scale NN cord-280642-cvxni7cd 216 3 of of IN cord-280642-cvxni7cd 216 4 our -PRON- PRP$ cord-280642-cvxni7cd 216 5 platform platform NN cord-280642-cvxni7cd 216 6 will will MD cord-280642-cvxni7cd 216 7 shortly shortly RB cord-280642-cvxni7cd 216 8 expand expand VB cord-280642-cvxni7cd 216 9 further further RB cord-280642-cvxni7cd 216 10 , , , cord-280642-cvxni7cd 216 11 and and CC cord-280642-cvxni7cd 216 12 we -PRON- PRP cord-280642-cvxni7cd 216 13 will will MD cord-280642-cvxni7cd 216 14 report report VB cord-280642-cvxni7cd 216 15 updated update VBN cord-280642-cvxni7cd 216 16 analyses analysis NNS cord-280642-cvxni7cd 216 17 over over IN cord-280642-cvxni7cd 216 18 time time NN cord-280642-cvxni7cd 216 19 . . . cord-280642-cvxni7cd 217 1 Another another DT cord-280642-cvxni7cd 217 2 key key JJ cord-280642-cvxni7cd 217 3 strength strength NN cord-280642-cvxni7cd 217 4 is be VBZ cord-280642-cvxni7cd 217 5 our -PRON- PRP$ cord-280642-cvxni7cd 217 6 use use NN cord-280642-cvxni7cd 217 7 of of IN cord-280642-cvxni7cd 217 8 open open JJ cord-280642-cvxni7cd 217 9 methods method NNS cord-280642-cvxni7cd 217 10 : : : cord-280642-cvxni7cd 217 11 we -PRON- PRP cord-280642-cvxni7cd 217 12 pre pre VBP cord-280642-cvxni7cd 217 13 - - VBD cord-280642-cvxni7cd 217 14 specified specify VBN cord-280642-cvxni7cd 217 15 our -PRON- PRP$ cord-280642-cvxni7cd 217 16 analysis analysis NN cord-280642-cvxni7cd 217 17 plan plan NN cord-280642-cvxni7cd 217 18 and and CC cord-280642-cvxni7cd 217 19 have have VBP cord-280642-cvxni7cd 217 20 shared share VBN cord-280642-cvxni7cd 217 21 our -PRON- PRP$ cord-280642-cvxni7cd 217 22 full full JJ cord-280642-cvxni7cd 217 23 analytic analytic JJ cord-280642-cvxni7cd 217 24 code code NN cord-280642-cvxni7cd 217 25 and and CC cord-280642-cvxni7cd 217 26 all all DT cord-280642-cvxni7cd 217 27 code code NN cord-280642-cvxni7cd 217 28 lists list NNS cord-280642-cvxni7cd 217 29 for for IN cord-280642-cvxni7cd 217 30 review review NN cord-280642-cvxni7cd 217 31 and and CC cord-280642-cvxni7cd 217 32 re re NN cord-280642-cvxni7cd 217 33 - - NN cord-280642-cvxni7cd 217 34 use use NN cord-280642-cvxni7cd 217 35 . . . cord-280642-cvxni7cd 218 1 We -PRON- PRP cord-280642-cvxni7cd 218 2 ascertained ascertain VBD cord-280642-cvxni7cd 218 3 patients patient NNS cord-280642-cvxni7cd 218 4 ' ' POS cord-280642-cvxni7cd 218 5 demographics demographic NNS cord-280642-cvxni7cd 218 6 , , , cord-280642-cvxni7cd 218 7 medications medication NNS cord-280642-cvxni7cd 218 8 and and CC cord-280642-cvxni7cd 218 9 comorbidities comorbiditie NNS cord-280642-cvxni7cd 218 10 from from IN cord-280642-cvxni7cd 218 11 their -PRON- PRP$ cord-280642-cvxni7cd 218 12 full full JJ cord-280642-cvxni7cd 218 13 pseudonymised pseudonymised JJ cord-280642-cvxni7cd 218 14 longitudinal longitudinal JJ cord-280642-cvxni7cd 218 15 primary primary JJ cord-280642-cvxni7cd 218 16 care care NN cord-280642-cvxni7cd 218 17 records record NNS cord-280642-cvxni7cd 218 18 , , , cord-280642-cvxni7cd 218 19 providing provide VBG cord-280642-cvxni7cd 218 20 substantially substantially RB cord-280642-cvxni7cd 218 21 more more RBR cord-280642-cvxni7cd 218 22 detailed detailed JJ cord-280642-cvxni7cd 218 23 information information NN cord-280642-cvxni7cd 218 24 than than IN cord-280642-cvxni7cd 218 25 is be VBZ cord-280642-cvxni7cd 218 26 available available JJ cord-280642-cvxni7cd 218 27 in in IN cord-280642-cvxni7cd 218 28 hospital hospital NN cord-280642-cvxni7cd 218 29 records record NNS cord-280642-cvxni7cd 218 30 or or CC cord-280642-cvxni7cd 218 31 data datum NNS cord-280642-cvxni7cd 218 32 recorded record VBN cord-280642-cvxni7cd 218 33 at at IN cord-280642-cvxni7cd 218 34 time time NN cord-280642-cvxni7cd 218 35 of of IN cord-280642-cvxni7cd 218 36 admission admission NN cord-280642-cvxni7cd 218 37 alone alone RB cord-280642-cvxni7cd 218 38 , , , cord-280642-cvxni7cd 218 39 and and CC cord-280642-cvxni7cd 218 40 on on IN cord-280642-cvxni7cd 218 41 the the DT cord-280642-cvxni7cd 218 42 total total JJ cord-280642-cvxni7cd 218 43 population population NN cord-280642-cvxni7cd 218 44 at at IN cord-280642-cvxni7cd 218 45 risk risk NN cord-280642-cvxni7cd 218 46 rather rather RB cord-280642-cvxni7cd 218 47 than than IN cord-280642-cvxni7cd 218 48 the the DT cord-280642-cvxni7cd 218 49 selected select VBN cord-280642-cvxni7cd 218 50 subset subset JJ cord-280642-cvxni7cd 218 51 presenting present VBG cord-280642-cvxni7cd 218 52 for for IN cord-280642-cvxni7cd 218 53 treatment treatment NN cord-280642-cvxni7cd 218 54 in in IN cord-280642-cvxni7cd 218 55 hospital hospital NN cord-280642-cvxni7cd 218 56 . . . cord-280642-cvxni7cd 219 1 Linkage linkage NN cord-280642-cvxni7cd 219 2 to to IN cord-280642-cvxni7cd 219 3 ONS on NNS cord-280642-cvxni7cd 219 4 allowed allow VBD cord-280642-cvxni7cd 219 5 censoring censoring NN cord-280642-cvxni7cd 219 6 of of IN cord-280642-cvxni7cd 219 7 data datum NNS cord-280642-cvxni7cd 219 8 in in IN cord-280642-cvxni7cd 219 9 the the DT cord-280642-cvxni7cd 219 10 control control NN cord-280642-cvxni7cd 219 11 population population NN cord-280642-cvxni7cd 219 12 for for IN cord-280642-cvxni7cd 219 13 patients patient NNS cord-280642-cvxni7cd 219 14 who who WP cord-280642-cvxni7cd 219 15 had have VBD cord-280642-cvxni7cd 219 16 died die VBN cord-280642-cvxni7cd 219 17 outside outside JJ cord-280642-cvxni7cd 219 18 hospital hospital NN cord-280642-cvxni7cd 219 19 or or CC cord-280642-cvxni7cd 219 20 from from IN cord-280642-cvxni7cd 219 21 other other JJ cord-280642-cvxni7cd 219 22 causes cause NNS cord-280642-cvxni7cd 219 23 . . . cord-280642-cvxni7cd 220 1 Analyses analysis NNS cord-280642-cvxni7cd 220 2 were be VBD cord-280642-cvxni7cd 220 3 stratified stratify VBN cord-280642-cvxni7cd 220 4 by by IN cord-280642-cvxni7cd 220 5 area area NN cord-280642-cvxni7cd 220 6 to to TO cord-280642-cvxni7cd 220 7 account account VB cord-280642-cvxni7cd 220 8 for for IN cord-280642-cvxni7cd 220 9 known know VBN cord-280642-cvxni7cd 220 10 geographical geographical JJ cord-280642-cvxni7cd 220 11 differences difference NNS cord-280642-cvxni7cd 220 12 in in IN cord-280642-cvxni7cd 220 13 incidence incidence NN cord-280642-cvxni7cd 220 14 of of IN cord-280642-cvxni7cd 220 15 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 220 16 . . . cord-280642-cvxni7cd 221 1 We -PRON- PRP cord-280642-cvxni7cd 221 2 also also RB cord-280642-cvxni7cd 221 3 identify identify VBP cord-280642-cvxni7cd 221 4 important important JJ cord-280642-cvxni7cd 221 5 limitations limitation NNS cord-280642-cvxni7cd 221 6 . . . cord-280642-cvxni7cd 222 1 Using use VBG cord-280642-cvxni7cd 222 2 CPNS CPNS NNP cord-280642-cvxni7cd 222 3 data datum NNS cord-280642-cvxni7cd 222 4 alone alone RB cord-280642-cvxni7cd 222 5 relies rely VBZ cord-280642-cvxni7cd 222 6 on on IN cord-280642-cvxni7cd 222 7 hospitals hospital NNS cord-280642-cvxni7cd 222 8 completing complete VBG cord-280642-cvxni7cd 222 9 a a DT cord-280642-cvxni7cd 222 10 new new JJ cord-280642-cvxni7cd 222 11 return return NN cord-280642-cvxni7cd 222 12 under under IN cord-280642-cvxni7cd 222 13 emergency emergency NN cord-280642-cvxni7cd 222 14 conditions condition NNS cord-280642-cvxni7cd 222 15 ; ; : cord-280642-cvxni7cd 222 16 furthermore furthermore RB cord-280642-cvxni7cd 222 17 COVID-19 covid-19 VBP cord-280642-cvxni7cd 222 18 deaths death NNS cord-280642-cvxni7cd 222 19 among among IN cord-280642-cvxni7cd 222 20 people people NNS cord-280642-cvxni7cd 222 21 with with IN cord-280642-cvxni7cd 222 22 false false JJ cord-280642-cvxni7cd 222 23 - - HYPH cord-280642-cvxni7cd 222 24 negative negative JJ cord-280642-cvxni7cd 222 25 tests test NNS cord-280642-cvxni7cd 222 26 and and CC cord-280642-cvxni7cd 222 27 those those DT cord-280642-cvxni7cd 222 28 untested untested JJ cord-280642-cvxni7cd 222 29 may may MD cord-280642-cvxni7cd 222 30 not not RB cord-280642-cvxni7cd 222 31 have have VB cord-280642-cvxni7cd 222 32 been be VBN cord-280642-cvxni7cd 222 33 included include VBN cord-280642-cvxni7cd 222 34 ; ; : cord-280642-cvxni7cd 222 35 we -PRON- PRP cord-280642-cvxni7cd 222 36 will will MD cord-280642-cvxni7cd 222 37 validate validate VB cord-280642-cvxni7cd 222 38 CPNS CPNS NNP cord-280642-cvxni7cd 222 39 against against IN cord-280642-cvxni7cd 222 40 ONS ONS NNP cord-280642-cvxni7cd 222 41 data datum NNS cord-280642-cvxni7cd 222 42 ( ( -LRB- cord-280642-cvxni7cd 222 43 which which WDT cord-280642-cvxni7cd 222 44 has have VBZ cord-280642-cvxni7cd 222 45 a a DT cord-280642-cvxni7cd 222 46 longer long JJR cord-280642-cvxni7cd 222 47 delay delay NN cord-280642-cvxni7cd 222 48 to to IN cord-280642-cvxni7cd 222 49 reporting reporting NN cord-280642-cvxni7cd 222 50 ) ) -RRB- cord-280642-cvxni7cd 222 51 as as IN cord-280642-cvxni7cd 222 52 more more JJR cord-280642-cvxni7cd 222 53 cases case NNS cord-280642-cvxni7cd 222 54 arise arise VBP cord-280642-cvxni7cd 222 55 . . . cord-280642-cvxni7cd 223 1 This this DT cord-280642-cvxni7cd 223 2 initial initial JJ cord-280642-cvxni7cd 223 3 analysis analysis NN cord-280642-cvxni7cd 223 4 was be VBD cord-280642-cvxni7cd 223 5 focused focus VBN cord-280642-cvxni7cd 223 6 on on IN cord-280642-cvxni7cd 223 7 in in IN cord-280642-cvxni7cd 223 8 - - HYPH cord-280642-cvxni7cd 223 9 hospital hospital NN cord-280642-cvxni7cd 223 10 death death NN cord-280642-cvxni7cd 223 11 : : : cord-280642-cvxni7cd 223 12 our -PRON- PRP$ cord-280642-cvxni7cd 223 13 findings finding NNS cord-280642-cvxni7cd 223 14 therefore therefore RB cord-280642-cvxni7cd 223 15 reflect reflect VBP cord-280642-cvxni7cd 223 16 both both CC cord-280642-cvxni7cd 223 17 an an DT cord-280642-cvxni7cd 223 18 individual individual NN cord-280642-cvxni7cd 223 19 's 's POS cord-280642-cvxni7cd 223 20 risk risk NN cord-280642-cvxni7cd 223 21 of of IN cord-280642-cvxni7cd 223 22 infection infection NN cord-280642-cvxni7cd 223 23 , , , cord-280642-cvxni7cd 223 24 and and CC cord-280642-cvxni7cd 223 25 their -PRON- PRP$ cord-280642-cvxni7cd 223 26 risk risk NN cord-280642-cvxni7cd 223 27 of of IN cord-280642-cvxni7cd 223 28 dying die VBG cord-280642-cvxni7cd 223 29 once once RB cord-280642-cvxni7cd 223 30 infected infect VBN cord-280642-cvxni7cd 223 31 . . . cord-280642-cvxni7cd 224 1 We -PRON- PRP cord-280642-cvxni7cd 224 2 will will MD cord-280642-cvxni7cd 224 3 explore explore VB cord-280642-cvxni7cd 224 4 patient patient JJ cord-280642-cvxni7cd 224 5 trajectories trajectory NNS cord-280642-cvxni7cd 224 6 in in IN cord-280642-cvxni7cd 224 7 future future JJ cord-280642-cvxni7cd 224 8 research research NN cord-280642-cvxni7cd 224 9 using use VBG cord-280642-cvxni7cd 224 10 test test NN cord-280642-cvxni7cd 224 11 results result NNS cord-280642-cvxni7cd 224 12 and and CC cord-280642-cvxni7cd 224 13 A&E A&E NNP cord-280642-cvxni7cd 224 14 presentation presentation NN cord-280642-cvxni7cd 224 15 data datum NNS cord-280642-cvxni7cd 224 16 . . . cord-280642-cvxni7cd 225 1 CC CC NNP cord-280642-cvxni7cd 225 2 - - : cord-280642-cvxni7cd 225 3 BY by IN cord-280642-cvxni7cd 225 4 4.0 4.0 CD cord-280642-cvxni7cd 225 5 International international JJ cord-280642-cvxni7cd 225 6 license license NN cord-280642-cvxni7cd 226 1 It -PRON- PRP cord-280642-cvxni7cd 226 2 is be VBZ cord-280642-cvxni7cd 226 3 made make VBN cord-280642-cvxni7cd 226 4 available available JJ cord-280642-cvxni7cd 226 5 under under IN cord-280642-cvxni7cd 226 6 a a DT cord-280642-cvxni7cd 227 1 is be VBZ cord-280642-cvxni7cd 227 2 the the DT cord-280642-cvxni7cd 227 3 author author NN cord-280642-cvxni7cd 227 4 / / SYM cord-280642-cvxni7cd 227 5 funder funder NN cord-280642-cvxni7cd 227 6 , , , cord-280642-cvxni7cd 227 7 who who WP cord-280642-cvxni7cd 227 8 has have VBZ cord-280642-cvxni7cd 227 9 granted grant VBN cord-280642-cvxni7cd 227 10 medRxiv medRxiv NNS cord-280642-cvxni7cd 227 11 a a DT cord-280642-cvxni7cd 227 12 license license NN cord-280642-cvxni7cd 227 13 to to TO cord-280642-cvxni7cd 227 14 display display VB cord-280642-cvxni7cd 227 15 the the DT cord-280642-cvxni7cd 227 16 preprint preprint NN cord-280642-cvxni7cd 227 17 in in IN cord-280642-cvxni7cd 227 18 perpetuity perpetuity NN cord-280642-cvxni7cd 227 19 . . . cord-280642-cvxni7cd 228 1 The the DT cord-280642-cvxni7cd 228 2 copyright copyright NN cord-280642-cvxni7cd 228 3 holder holder NN cord-280642-cvxni7cd 228 4 for for IN cord-280642-cvxni7cd 228 5 this this DT cord-280642-cvxni7cd 228 6 preprint preprint NN cord-280642-cvxni7cd 228 7 this this DT cord-280642-cvxni7cd 228 8 version version NN cord-280642-cvxni7cd 228 9 posted post VBN cord-280642-cvxni7cd 228 10 May May NNP cord-280642-cvxni7cd 228 11 7 7 CD cord-280642-cvxni7cd 228 12 , , , cord-280642-cvxni7cd 228 13 2020 2020 CD cord-280642-cvxni7cd 228 14 . . . cord-280642-cvxni7cd 228 15 . . . cord-280642-cvxni7cd 229 1 https://doi.org/10.1101/2020.05.06.20092999 https://doi.org/10.1101/2020.05.06.20092999 NNP cord-280642-cvxni7cd 229 2 doi doi NNP cord-280642-cvxni7cd 229 3 : : : cord-280642-cvxni7cd 230 1 medRxiv medRxiv NNP cord-280642-cvxni7cd 230 2 preprint preprint NN cord-280642-cvxni7cd 230 3 which which WDT cord-280642-cvxni7cd 230 4 are be VBP cord-280642-cvxni7cd 230 5 now now RB cord-280642-cvxni7cd 230 6 being be VBG cord-280642-cvxni7cd 230 7 linked link VBN cord-280642-cvxni7cd 230 8 on on IN cord-280642-cvxni7cd 230 9 the the DT cord-280642-cvxni7cd 230 10 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 230 11 platform platform NN cord-280642-cvxni7cd 230 12 . . . cord-280642-cvxni7cd 231 1 Censoring censor VBG cord-280642-cvxni7cd 231 2 patients patient NNS cord-280642-cvxni7cd 231 3 at at IN cord-280642-cvxni7cd 231 4 date date NN cord-280642-cvxni7cd 231 5 of of IN cord-280642-cvxni7cd 231 6 death death NN cord-280642-cvxni7cd 231 7 from from IN cord-280642-cvxni7cd 231 8 other other JJ cord-280642-cvxni7cd 231 9 causes cause NNS cord-280642-cvxni7cd 231 10 , , , cord-280642-cvxni7cd 231 11 or or CC cord-280642-cvxni7cd 231 12 outside outside JJ cord-280642-cvxni7cd 231 13 hospital hospital NN cord-280642-cvxni7cd 231 14 , , , cord-280642-cvxni7cd 231 15 was be VBD cord-280642-cvxni7cd 231 16 only only RB cord-280642-cvxni7cd 231 17 possible possible JJ cord-280642-cvxni7cd 231 18 until until IN cord-280642-cvxni7cd 231 19 16th 16th JJ cord-280642-cvxni7cd 231 20 April April NNP cord-280642-cvxni7cd 231 21 2020 2020 CD cord-280642-cvxni7cd 231 22 , , , cord-280642-cvxni7cd 231 23 9 9 CD cord-280642-cvxni7cd 231 24 days day NNS cord-280642-cvxni7cd 231 25 prior prior RB cord-280642-cvxni7cd 231 26 to to TO cord-280642-cvxni7cd 231 27 study study NN cord-280642-cvxni7cd 231 28 end end NN cord-280642-cvxni7cd 231 29 . . . cord-280642-cvxni7cd 232 1 Rather rather RB cord-280642-cvxni7cd 232 2 than than IN cord-280642-cvxni7cd 232 3 ending end VBG cord-280642-cvxni7cd 232 4 the the DT cord-280642-cvxni7cd 232 5 study study NN cord-280642-cvxni7cd 232 6 earlier early RBR cord-280642-cvxni7cd 232 7 , , , cord-280642-cvxni7cd 232 8 greatly greatly RB cord-280642-cvxni7cd 232 9 reducing reduce VBG cord-280642-cvxni7cd 232 10 case case NN cord-280642-cvxni7cd 232 11 numbers number NNS cord-280642-cvxni7cd 232 12 , , , cord-280642-cvxni7cd 232 13 we -PRON- PRP cord-280642-cvxni7cd 232 14 end end VBP cord-280642-cvxni7cd 232 15 at at IN cord-280642-cvxni7cd 232 16 25 25 CD cord-280642-cvxni7cd 232 17 April April NNP cord-280642-cvxni7cd 232 18 , , , cord-280642-cvxni7cd 232 19 acknowledging acknowledge VBG cord-280642-cvxni7cd 232 20 that that IN cord-280642-cvxni7cd 232 21 censoring censoring NN cord-280642-cvxni7cd 232 22 would would MD cord-280642-cvxni7cd 232 23 be be VB cord-280642-cvxni7cd 232 24 incomplete incomplete JJ cord-280642-cvxni7cd 232 25 for for IN cord-280642-cvxni7cd 232 26 the the DT cord-280642-cvxni7cd 232 27 last last JJ cord-280642-cvxni7cd 232 28 9 9 CD cord-280642-cvxni7cd 232 29 days day NNS cord-280642-cvxni7cd 232 30 . . . cord-280642-cvxni7cd 233 1 Consequently consequently RB cord-280642-cvxni7cd 233 2 a a DT cord-280642-cvxni7cd 233 3 small small JJ cord-280642-cvxni7cd 233 4 number number NN cord-280642-cvxni7cd 233 5 of of IN cord-280642-cvxni7cd 233 6 the the DT cord-280642-cvxni7cd 233 7 sickest sick JJS cord-280642-cvxni7cd 233 8 individuals individual NNS cord-280642-cvxni7cd 233 9 , , , cord-280642-cvxni7cd 233 10 who who WP cord-280642-cvxni7cd 233 11 died die VBD cord-280642-cvxni7cd 233 12 after after IN cord-280642-cvxni7cd 233 13 being be VBG cord-280642-cvxni7cd 233 14 discharged discharge VBN cord-280642-cvxni7cd 233 15 from from IN cord-280642-cvxni7cd 233 16 hospital hospital NN cord-280642-cvxni7cd 233 17 , , , cord-280642-cvxni7cd 233 18 will will MD cord-280642-cvxni7cd 233 19 have have VB cord-280642-cvxni7cd 233 20 remained remain VBN cord-280642-cvxni7cd 233 21 in in IN cord-280642-cvxni7cd 233 22 the the DT cord-280642-cvxni7cd 233 23 " " `` cord-280642-cvxni7cd 233 24 at at IN cord-280642-cvxni7cd 233 25 risk risk NN cord-280642-cvxni7cd 233 26 " " '' cord-280642-cvxni7cd 233 27 group group NN cord-280642-cvxni7cd 233 28 over over IN cord-280642-cvxni7cd 233 29 the the DT cord-280642-cvxni7cd 233 30 last last JJ cord-280642-cvxni7cd 233 31 few few JJ cord-280642-cvxni7cd 233 32 days day NNS cord-280642-cvxni7cd 233 33 of of IN cord-280642-cvxni7cd 233 34 study study NN cord-280642-cvxni7cd 233 35 time time NN cord-280642-cvxni7cd 233 36 when when WRB cord-280642-cvxni7cd 233 37 they -PRON- PRP cord-280642-cvxni7cd 233 38 should should MD cord-280642-cvxni7cd 233 39 be be VB cord-280642-cvxni7cd 233 40 censored censor VBN cord-280642-cvxni7cd 233 41 . . . cord-280642-cvxni7cd 234 1 This this DT cord-280642-cvxni7cd 234 2 would would MD cord-280642-cvxni7cd 234 3 most most RBS cord-280642-cvxni7cd 234 4 likely likely RB cord-280642-cvxni7cd 234 5 apply apply VB cord-280642-cvxni7cd 234 6 to to IN cord-280642-cvxni7cd 234 7 those those DT cord-280642-cvxni7cd 234 8 with with IN cord-280642-cvxni7cd 234 9 risk risk NN cord-280642-cvxni7cd 234 10 factors factor NNS cord-280642-cvxni7cd 234 11 present present JJ cord-280642-cvxni7cd 234 12 , , , cord-280642-cvxni7cd 234 13 and and CC cord-280642-cvxni7cd 234 14 therefore therefore RB cord-280642-cvxni7cd 234 15 attenuate attenuate VBP cord-280642-cvxni7cd 234 16 HRs hr NNS cord-280642-cvxni7cd 234 17 , , , cord-280642-cvxni7cd 234 18 but but CC cord-280642-cvxni7cd 234 19 any any DT cord-280642-cvxni7cd 234 20 impact impact NN cord-280642-cvxni7cd 234 21 is be VBZ cord-280642-cvxni7cd 234 22 likely likely JJ cord-280642-cvxni7cd 234 23 to to TO cord-280642-cvxni7cd 234 24 be be VB cord-280642-cvxni7cd 234 25 small small JJ cord-280642-cvxni7cd 234 26 : : : cord-280642-cvxni7cd 234 27 a a DT cord-280642-cvxni7cd 234 28 sensitivity sensitivity NN cord-280642-cvxni7cd 234 29 analysis analysis NN cord-280642-cvxni7cd 234 30 with with IN cord-280642-cvxni7cd 234 31 all all DT cord-280642-cvxni7cd 234 32 data datum NNS cord-280642-cvxni7cd 234 33 censored censor VBN cord-280642-cvxni7cd 234 34 at at IN cord-280642-cvxni7cd 234 35 6 6 CD cord-280642-cvxni7cd 234 36 April April NNP cord-280642-cvxni7cd 234 37 showed show VBD cord-280642-cvxni7cd 234 38 minimal minimal JJ cord-280642-cvxni7cd 234 39 differences difference NNS cord-280642-cvxni7cd 234 40 . . . cord-280642-cvxni7cd 235 1 Our -PRON- PRP$ cord-280642-cvxni7cd 235 2 analysis analysis NN cord-280642-cvxni7cd 235 3 to to IN cord-280642-cvxni7cd 235 4 date date NN cord-280642-cvxni7cd 235 5 covers cover VBZ cord-280642-cvxni7cd 235 6 40 40 CD cord-280642-cvxni7cd 235 7 % % NN cord-280642-cvxni7cd 235 8 of of IN cord-280642-cvxni7cd 235 9 the the DT cord-280642-cvxni7cd 235 10 population population NN cord-280642-cvxni7cd 235 11 , , , cord-280642-cvxni7cd 235 12 but but CC cord-280642-cvxni7cd 235 13 may may MD cord-280642-cvxni7cd 235 14 not not RB cord-280642-cvxni7cd 235 15 yet yet RB cord-280642-cvxni7cd 235 16 be be VB cord-280642-cvxni7cd 235 17 fully fully RB cord-280642-cvxni7cd 235 18 representative representative JJ cord-280642-cvxni7cd 235 19 as as IN cord-280642-cvxni7cd 235 20 it -PRON- PRP cord-280642-cvxni7cd 235 21 currently currently RB cord-280642-cvxni7cd 235 22 includes include VBZ cord-280642-cvxni7cd 235 23 only only RB cord-280642-cvxni7cd 235 24 practices practice NNS cord-280642-cvxni7cd 235 25 using use VBG cord-280642-cvxni7cd 235 26 the the DT cord-280642-cvxni7cd 235 27 EHR EHR NNP cord-280642-cvxni7cd 235 28 software software NN cord-280642-cvxni7cd 235 29 SystmOne SystmOne NNP cord-280642-cvxni7cd 236 1 : : : cord-280642-cvxni7cd 236 2 there there EX cord-280642-cvxni7cd 236 3 is be VBZ cord-280642-cvxni7cd 236 4 substantial substantial JJ cord-280642-cvxni7cd 236 5 geographic geographic JJ cord-280642-cvxni7cd 236 6 variation variation NN cord-280642-cvxni7cd 236 7 in in IN cord-280642-cvxni7cd 236 8 choice choice NN cord-280642-cvxni7cd 236 9 of of IN cord-280642-cvxni7cd 236 10 EHR EHR NNP cord-280642-cvxni7cd 236 11 system system NN cord-280642-cvxni7cd 236 12 and and CC cord-280642-cvxni7cd 236 13 in in IN cord-280642-cvxni7cd 236 14 London London NNP cord-280642-cvxni7cd 236 15 , , , cord-280642-cvxni7cd 236 16 where where WRB cord-280642-cvxni7cd 236 17 many many JJ cord-280642-cvxni7cd 236 18 earlier early JJR cord-280642-cvxni7cd 236 19 COVID-19 covid-19 JJ cord-280642-cvxni7cd 236 20 cases case NNS cord-280642-cvxni7cd 236 21 occurred occur VBD cord-280642-cvxni7cd 236 22 , , , cord-280642-cvxni7cd 236 23 only only RB cord-280642-cvxni7cd 236 24 17 17 CD cord-280642-cvxni7cd 236 25 % % NN cord-280642-cvxni7cd 236 26 of of IN cord-280642-cvxni7cd 236 27 general general JJ cord-280642-cvxni7cd 236 28 practices practice NNS cord-280642-cvxni7cd 236 29 use use VBP cord-280642-cvxni7cd 236 30 SystmOne SystmOne NNP cord-280642-cvxni7cd 236 31 . . . cord-280642-cvxni7cd 237 1 Additionally additionally RB cord-280642-cvxni7cd 237 2 it -PRON- PRP cord-280642-cvxni7cd 237 3 has have VBZ cord-280642-cvxni7cd 237 4 been be VBN cord-280642-cvxni7cd 237 5 shown show VBN cord-280642-cvxni7cd 237 6 that that IN cord-280642-cvxni7cd 237 7 the the DT cord-280642-cvxni7cd 237 8 user user NN cord-280642-cvxni7cd 237 9 interface interface NN cord-280642-cvxni7cd 237 10 of of IN cord-280642-cvxni7cd 237 11 electronic electronic JJ cord-280642-cvxni7cd 237 12 health health NN cord-280642-cvxni7cd 237 13 records record NNS cord-280642-cvxni7cd 237 14 can can MD cord-280642-cvxni7cd 237 15 affect affect VB cord-280642-cvxni7cd 237 16 prescribing prescribe VBG cord-280642-cvxni7cd 237 17 of of IN cord-280642-cvxni7cd 237 18 certain certain JJ cord-280642-cvxni7cd 237 19 medicines medicine NNS cord-280642-cvxni7cd 237 20 42 42 CD cord-280642-cvxni7cd 237 21 - - SYM cord-280642-cvxni7cd 237 22 44 44 CD cord-280642-cvxni7cd 238 1 so so CC cord-280642-cvxni7cd 238 2 it -PRON- PRP cord-280642-cvxni7cd 238 3 is be VBZ cord-280642-cvxni7cd 238 4 possible possible JJ cord-280642-cvxni7cd 238 5 that that IN cord-280642-cvxni7cd 238 6 coding coding NN cord-280642-cvxni7cd 238 7 of of IN cord-280642-cvxni7cd 238 8 conditions condition NNS cord-280642-cvxni7cd 238 9 may may MD cord-280642-cvxni7cd 238 10 vary vary VB cord-280642-cvxni7cd 238 11 between between IN cord-280642-cvxni7cd 238 12 systems system NNS cord-280642-cvxni7cd 238 13 ; ; : cord-280642-cvxni7cd 238 14 again again RB cord-280642-cvxni7cd 238 15 we -PRON- PRP cord-280642-cvxni7cd 238 16 will will MD cord-280642-cvxni7cd 238 17 evaluate evaluate VB cord-280642-cvxni7cd 238 18 this this DT cord-280642-cvxni7cd 238 19 further further RB cord-280642-cvxni7cd 238 20 with with IN cord-280642-cvxni7cd 238 21 more more JJR cord-280642-cvxni7cd 238 22 data datum NNS cord-280642-cvxni7cd 238 23 . . . cord-280642-cvxni7cd 239 1 Primary primary JJ cord-280642-cvxni7cd 239 2 care care NN cord-280642-cvxni7cd 239 3 records record NNS cord-280642-cvxni7cd 239 4 , , , cord-280642-cvxni7cd 239 5 though though IN cord-280642-cvxni7cd 239 6 detailed detailed JJ cord-280642-cvxni7cd 239 7 and and CC cord-280642-cvxni7cd 239 8 longitudinal longitudinal JJ cord-280642-cvxni7cd 239 9 , , , cord-280642-cvxni7cd 239 10 can can MD cord-280642-cvxni7cd 239 11 be be VB cord-280642-cvxni7cd 239 12 incomplete incomplete JJ cord-280642-cvxni7cd 239 13 for for IN cord-280642-cvxni7cd 239 14 data datum NNS cord-280642-cvxni7cd 239 15 on on IN cord-280642-cvxni7cd 239 16 risk risk NN cord-280642-cvxni7cd 239 17 factors factor NNS cord-280642-cvxni7cd 239 18 and and CC cord-280642-cvxni7cd 239 19 other other JJ cord-280642-cvxni7cd 239 20 covariates covariate NNS cord-280642-cvxni7cd 239 21 . . . cord-280642-cvxni7cd 240 1 In in IN cord-280642-cvxni7cd 240 2 particular particular JJ cord-280642-cvxni7cd 240 3 , , , cord-280642-cvxni7cd 240 4 ethnicity ethnicity NN cord-280642-cvxni7cd 240 5 was be VBD cord-280642-cvxni7cd 240 6 not not RB cord-280642-cvxni7cd 240 7 recorded record VBN cord-280642-cvxni7cd 240 8 in in IN cord-280642-cvxni7cd 240 9 approximately approximately RB cord-280642-cvxni7cd 240 10 26 26 CD cord-280642-cvxni7cd 240 11 % % NN cord-280642-cvxni7cd 240 12 of of IN cord-280642-cvxni7cd 240 13 patients patient NNS cord-280642-cvxni7cd 240 14 included include VBN cord-280642-cvxni7cd 240 15 ; ; : cord-280642-cvxni7cd 240 16 prior prior JJ cord-280642-cvxni7cd 240 17 research research NN cord-280642-cvxni7cd 240 18 has have VBZ cord-280642-cvxni7cd 240 19 shown show VBN cord-280642-cvxni7cd 240 20 that that IN cord-280642-cvxni7cd 240 21 when when WRB cord-280642-cvxni7cd 240 22 ethnicity ethnicity NN cord-280642-cvxni7cd 240 23 is be VBZ cord-280642-cvxni7cd 240 24 recorded record VBN cord-280642-cvxni7cd 240 25 in in IN cord-280642-cvxni7cd 240 26 EHR EHR NNP cord-280642-cvxni7cd 240 27 its -PRON- PRP$ cord-280642-cvxni7cd 240 28 distribution distribution NN cord-280642-cvxni7cd 240 29 is be VBZ cord-280642-cvxni7cd 240 30 very very RB cord-280642-cvxni7cd 240 31 similar similar JJ cord-280642-cvxni7cd 240 32 to to IN cord-280642-cvxni7cd 240 33 that that DT cord-280642-cvxni7cd 240 34 in in IN cord-280642-cvxni7cd 240 35 census census NN cord-280642-cvxni7cd 240 36 ethnicity ethnicity NN cord-280642-cvxni7cd 240 37 data datum NNS cord-280642-cvxni7cd 240 38 . . . cord-280642-cvxni7cd 241 1 45 45 CD cord-280642-cvxni7cd 241 2 Obesity obesity NN cord-280642-cvxni7cd 241 3 and and CC cord-280642-cvxni7cd 241 4 smoking smoking NN cord-280642-cvxni7cd 241 5 were be VBD cord-280642-cvxni7cd 241 6 assumed assume VBN cord-280642-cvxni7cd 241 7 absent absent JJ cord-280642-cvxni7cd 241 8 if if IN cord-280642-cvxni7cd 241 9 missing miss VBG cord-280642-cvxni7cd 241 10 ; ; : cord-280642-cvxni7cd 241 11 patients patient NNS cord-280642-cvxni7cd 241 12 with with IN cord-280642-cvxni7cd 241 13 missing miss VBG cord-280642-cvxni7cd 241 14 creatinine creatinine NN cord-280642-cvxni7cd 241 15 and and CC cord-280642-cvxni7cd 241 16 blood blood NN cord-280642-cvxni7cd 241 17 pressure pressure NN cord-280642-cvxni7cd 241 18 measurements measurement NNS cord-280642-cvxni7cd 241 19 were be VBD cord-280642-cvxni7cd 241 20 included include VBN cord-280642-cvxni7cd 241 21 in in IN cord-280642-cvxni7cd 241 22 the the DT cord-280642-cvxni7cd 241 23 categories category NNS cord-280642-cvxni7cd 241 24 denoting denote VBG cord-280642-cvxni7cd 241 25 no no DT cord-280642-cvxni7cd 241 26 evidence evidence NN cord-280642-cvxni7cd 241 27 of of IN cord-280642-cvxni7cd 241 28 reduced reduce VBN cord-280642-cvxni7cd 241 29 kidney kidney NN cord-280642-cvxni7cd 241 30 function function NN cord-280642-cvxni7cd 241 31 or or CC cord-280642-cvxni7cd 241 32 high high JJ cord-280642-cvxni7cd 241 33 blood blood NN cord-280642-cvxni7cd 241 34 pressure pressure NN cord-280642-cvxni7cd 241 35 respectively respectively RB cord-280642-cvxni7cd 241 36 . . . cord-280642-cvxni7cd 242 1 We -PRON- PRP cord-280642-cvxni7cd 242 2 undertook undertake VBD cord-280642-cvxni7cd 242 3 a a DT cord-280642-cvxni7cd 242 4 number number NN cord-280642-cvxni7cd 242 5 of of IN cord-280642-cvxni7cd 242 6 sensitivity sensitivity NN cord-280642-cvxni7cd 242 7 analyses analysis NNS cord-280642-cvxni7cd 242 8 to to TO cord-280642-cvxni7cd 242 9 assess assess VB cord-280642-cvxni7cd 242 10 robustness robustness NN cord-280642-cvxni7cd 242 11 of of IN cord-280642-cvxni7cd 242 12 these these DT cord-280642-cvxni7cd 242 13 approaches approach NNS cord-280642-cvxni7cd 242 14 , , , cord-280642-cvxni7cd 242 15 hazard hazard NN cord-280642-cvxni7cd 242 16 ratios ratio NNS cord-280642-cvxni7cd 242 17 were be VBD cord-280642-cvxni7cd 242 18 similar similar JJ cord-280642-cvxni7cd 242 19 across across IN cord-280642-cvxni7cd 242 20 analyses analysis NNS cord-280642-cvxni7cd 242 21 . . . cord-280642-cvxni7cd 243 1 Deprivation deprivation NN cord-280642-cvxni7cd 243 2 score score NN cord-280642-cvxni7cd 243 3 may may MD cord-280642-cvxni7cd 243 4 be be VB cord-280642-cvxni7cd 243 5 inaccurate inaccurate JJ cord-280642-cvxni7cd 243 6 for for IN cord-280642-cvxni7cd 243 7 any any DT cord-280642-cvxni7cd 243 8 patients patient NNS cord-280642-cvxni7cd 243 9 without without IN cord-280642-cvxni7cd 243 10 an an DT cord-280642-cvxni7cd 243 11 up up NN cord-280642-cvxni7cd 243 12 - - HYPH cord-280642-cvxni7cd 243 13 to to IN cord-280642-cvxni7cd 243 14 - - HYPH cord-280642-cvxni7cd 243 15 date date NN cord-280642-cvxni7cd 243 16 address address NN cord-280642-cvxni7cd 243 17 , , , cord-280642-cvxni7cd 243 18 but but CC cord-280642-cvxni7cd 243 19 this this DT cord-280642-cvxni7cd 243 20 is be VBZ cord-280642-cvxni7cd 243 21 unlikely unlikely JJ cord-280642-cvxni7cd 243 22 to to TO cord-280642-cvxni7cd 243 23 introduce introduce VB cord-280642-cvxni7cd 243 24 a a DT cord-280642-cvxni7cd 243 25 strong strong JJ cord-280642-cvxni7cd 243 26 bias bias NN cord-280642-cvxni7cd 243 27 in in IN cord-280642-cvxni7cd 243 28 any any DT cord-280642-cvxni7cd 243 29 particular particular JJ cord-280642-cvxni7cd 243 30 direction direction NN cord-280642-cvxni7cd 243 31 . . . cord-280642-cvxni7cd 244 1 Deviations deviation NNS cord-280642-cvxni7cd 244 2 from from IN cord-280642-cvxni7cd 244 3 proportional proportional JJ cord-280642-cvxni7cd 244 4 hazards hazard NNS cord-280642-cvxni7cd 244 5 were be VBD cord-280642-cvxni7cd 244 6 detected detect VBN cord-280642-cvxni7cd 244 7 . . . cord-280642-cvxni7cd 245 1 This this DT cord-280642-cvxni7cd 245 2 could could MD cord-280642-cvxni7cd 245 3 be be VB cord-280642-cvxni7cd 245 4 partly partly RB cord-280642-cvxni7cd 245 5 or or CC cord-280642-cvxni7cd 245 6 wholly wholly RB cord-280642-cvxni7cd 245 7 due due JJ cord-280642-cvxni7cd 245 8 to to IN cord-280642-cvxni7cd 245 9 the the DT cord-280642-cvxni7cd 245 10 very very RB cord-280642-cvxni7cd 245 11 large large JJ cord-280642-cvxni7cd 245 12 numbers number NNS cord-280642-cvxni7cd 245 13 included include VBD cord-280642-cvxni7cd 245 14 meaning mean VBG cord-280642-cvxni7cd 245 15 small small JJ cord-280642-cvxni7cd 245 16 deviations deviation NNS cord-280642-cvxni7cd 245 17 are be VBP cord-280642-cvxni7cd 245 18 statistically statistically RB cord-280642-cvxni7cd 245 19 significant significant JJ cord-280642-cvxni7cd 245 20 , , , cord-280642-cvxni7cd 245 21 or or CC cord-280642-cvxni7cd 245 22 due due JJ cord-280642-cvxni7cd 245 23 to to IN cord-280642-cvxni7cd 245 24 unmeasured unmeasured JJ cord-280642-cvxni7cd 245 25 covariates covariate NNS cord-280642-cvxni7cd 245 26 . . . cord-280642-cvxni7cd 246 1 However however RB cord-280642-cvxni7cd 246 2 , , , cord-280642-cvxni7cd 246 3 it -PRON- PRP cord-280642-cvxni7cd 246 4 may may MD cord-280642-cvxni7cd 246 5 have have VB cord-280642-cvxni7cd 246 6 been be VBN cord-280642-cvxni7cd 246 7 due due JJ cord-280642-cvxni7cd 246 8 to to IN cord-280642-cvxni7cd 246 9 rapid rapid JJ cord-280642-cvxni7cd 246 10 changes change NNS cord-280642-cvxni7cd 246 11 in in IN cord-280642-cvxni7cd 246 12 social social JJ cord-280642-cvxni7cd 246 13 behaviours behaviour NNS cord-280642-cvxni7cd 246 14 following follow VBG cord-280642-cvxni7cd 246 15 government government NN cord-280642-cvxni7cd 246 16 advice advice NN cord-280642-cvxni7cd 246 17 on on IN cord-280642-cvxni7cd 246 18 social social JJ cord-280642-cvxni7cd 246 19 distancing distancing NN cord-280642-cvxni7cd 246 20 , , , cord-280642-cvxni7cd 246 21 shielding shielding NN cord-280642-cvxni7cd 246 22 , , , cord-280642-cvxni7cd 246 23 and and CC cord-280642-cvxni7cd 246 24 changes change NNS cord-280642-cvxni7cd 246 25 in in IN cord-280642-cvxni7cd 246 26 the the DT cord-280642-cvxni7cd 246 27 pattern pattern NN cord-280642-cvxni7cd 246 28 and and CC cord-280642-cvxni7cd 246 29 burden burden NN cord-280642-cvxni7cd 246 30 of of IN cord-280642-cvxni7cd 246 31 infection infection NN cord-280642-cvxni7cd 246 32 across across IN cord-280642-cvxni7cd 246 33 the the DT cord-280642-cvxni7cd 246 34 UK UK NNP cord-280642-cvxni7cd 246 35 , , , cord-280642-cvxni7cd 246 36 which which WDT cord-280642-cvxni7cd 246 37 may may MD cord-280642-cvxni7cd 246 38 also also RB cord-280642-cvxni7cd 246 39 have have VB cord-280642-cvxni7cd 246 40 affected affect VBN cord-280642-cvxni7cd 246 41 different different JJ cord-280642-cvxni7cd 246 42 patient patient NN cord-280642-cvxni7cd 246 43 groups group NNS cord-280642-cvxni7cd 246 44 differentially differentially RB cord-280642-cvxni7cd 246 45 . . . cord-280642-cvxni7cd 247 1 A a DT cord-280642-cvxni7cd 247 2 sensitivity sensitivity NN cord-280642-cvxni7cd 247 3 analysis analysis NN cord-280642-cvxni7cd 247 4 with with IN cord-280642-cvxni7cd 247 5 early early JJ cord-280642-cvxni7cd 247 6 censoring censoring NN cord-280642-cvxni7cd 247 7 at at IN cord-280642-cvxni7cd 247 8 6th 6th JJ cord-280642-cvxni7cd 247 9 April April NNP cord-280642-cvxni7cd 247 10 2020 2020 CD cord-280642-cvxni7cd 248 1 ( ( -LRB- cord-280642-cvxni7cd 248 2 before before IN cord-280642-cvxni7cd 248 3 social social JJ cord-280642-cvxni7cd 248 4 distancing distancing NN cord-280642-cvxni7cd 248 5 and and CC cord-280642-cvxni7cd 248 6 shielding shield VBG cord-280642-cvxni7cd 248 7 measures measure NNS cord-280642-cvxni7cd 248 8 would would MD cord-280642-cvxni7cd 248 9 be be VB cord-280642-cvxni7cd 248 10 likely likely JJ cord-280642-cvxni7cd 248 11 to to TO cord-280642-cvxni7cd 248 12 affect affect VB cord-280642-cvxni7cd 248 13 mortality mortality NN cord-280642-cvxni7cd 248 14 ) ) -RRB- cord-280642-cvxni7cd 248 15 showed show VBD cord-280642-cvxni7cd 248 16 no no DT cord-280642-cvxni7cd 248 17 evidence evidence NN cord-280642-cvxni7cd 248 18 of of IN cord-280642-cvxni7cd 248 19 non non JJ cord-280642-cvxni7cd 248 20 - - JJ cord-280642-cvxni7cd 248 21 proportional proportional JJ cord-280642-cvxni7cd 248 22 hazards hazard NNS cord-280642-cvxni7cd 248 23 ( ( -LRB- cord-280642-cvxni7cd 248 24 p=0.56 p=0.56 NNP cord-280642-cvxni7cd 248 25 ) ) -RRB- cord-280642-cvxni7cd 248 26 and and CC cord-280642-cvxni7cd 248 27 similar similar JJ cord-280642-cvxni7cd 248 28 results result NNS cord-280642-cvxni7cd 248 29 to to IN cord-280642-cvxni7cd 248 30 the the DT cord-280642-cvxni7cd 248 31 primary primary JJ cord-280642-cvxni7cd 248 32 model model NN cord-280642-cvxni7cd 248 33 , , , cord-280642-cvxni7cd 248 34 but but CC cord-280642-cvxni7cd 248 35 with with IN cord-280642-cvxni7cd 248 36 larger large JJR cord-280642-cvxni7cd 248 37 hazard hazard NN cord-280642-cvxni7cd 248 38 ratios ratio NNS cord-280642-cvxni7cd 248 39 for for IN cord-280642-cvxni7cd 248 40 several several JJ cord-280642-cvxni7cd 248 41 risk risk NN cord-280642-cvxni7cd 248 42 factors factor NNS cord-280642-cvxni7cd 248 43 . . . cord-280642-cvxni7cd 249 1 This this DT cord-280642-cvxni7cd 249 2 is be VBZ cord-280642-cvxni7cd 249 3 consistent consistent JJ cord-280642-cvxni7cd 249 4 with with IN cord-280642-cvxni7cd 249 5 the the DT cord-280642-cvxni7cd 249 6 hypothesis hypothesis NN cord-280642-cvxni7cd 249 7 that that IN cord-280642-cvxni7cd 249 8 the the DT cord-280642-cvxni7cd 249 9 most most RBS cord-280642-cvxni7cd 249 10 at at IN cord-280642-cvxni7cd 249 11 - - HYPH cord-280642-cvxni7cd 249 12 risk risk NN cord-280642-cvxni7cd 249 13 patients patient NNS cord-280642-cvxni7cd 249 14 may may MD cord-280642-cvxni7cd 249 15 have have VB cord-280642-cvxni7cd 249 16 been be VBN cord-280642-cvxni7cd 249 17 more more RBR cord-280642-cvxni7cd 249 18 compliant compliant JJ cord-280642-cvxni7cd 249 19 with with IN cord-280642-cvxni7cd 249 20 social social JJ cord-280642-cvxni7cd 249 21 distancing distancing NN cord-280642-cvxni7cd 249 22 and and CC cord-280642-cvxni7cd 249 23 shielding shield VBG cord-280642-cvxni7cd 249 24 policies policy NNS cord-280642-cvxni7cd 249 25 introduced introduce VBN cord-280642-cvxni7cd 249 26 later later RB cord-280642-cvxni7cd 249 27 . . . cord-280642-cvxni7cd 250 1 In in IN cord-280642-cvxni7cd 250 2 contrast contrast NN cord-280642-cvxni7cd 250 3 , , , cord-280642-cvxni7cd 250 4 the the DT cord-280642-cvxni7cd 250 5 effect effect NN cord-280642-cvxni7cd 250 6 of of IN cord-280642-cvxni7cd 250 7 increased increase VBN cord-280642-cvxni7cd 250 8 deprivation deprivation NN cord-280642-cvxni7cd 250 9 appeared appear VBD cord-280642-cvxni7cd 250 10 to to TO cord-280642-cvxni7cd 250 11 be be VB cord-280642-cvxni7cd 250 12 smaller small JJR cord-280642-cvxni7cd 250 13 in in IN cord-280642-cvxni7cd 250 14 the the DT cord-280642-cvxni7cd 250 15 earlier early JJR cord-280642-cvxni7cd 250 16 period period NN cord-280642-cvxni7cd 250 17 , , , cord-280642-cvxni7cd 250 18 suggesting suggest VBG cord-280642-cvxni7cd 250 19 that that IN cord-280642-cvxni7cd 250 20 the the DT cord-280642-cvxni7cd 250 21 risk risk NN cord-280642-cvxni7cd 250 22 associated associate VBN cord-280642-cvxni7cd 250 23 with with IN cord-280642-cvxni7cd 250 24 deprivation deprivation NN cord-280642-cvxni7cd 250 25 may may MD cord-280642-cvxni7cd 250 26 have have VB cord-280642-cvxni7cd 250 27 increased increase VBN cord-280642-cvxni7cd 250 28 over over IN cord-280642-cvxni7cd 250 29 time time NN cord-280642-cvxni7cd 250 30 . . . cord-280642-cvxni7cd 251 1 Subsequent subsequent JJ cord-280642-cvxni7cd 251 2 analyses analysis NNS cord-280642-cvxni7cd 251 3 will will MD cord-280642-cvxni7cd 251 4 explore explore VB cord-280642-cvxni7cd 251 5 different different JJ cord-280642-cvxni7cd 251 6 analytical analytical JJ cord-280642-cvxni7cd 251 7 approaches approach NNS cord-280642-cvxni7cd 251 8 , , , cord-280642-cvxni7cd 251 9 including include VBG cord-280642-cvxni7cd 251 10 fitting fitting JJ cord-280642-cvxni7cd 251 11 interactions interaction NNS cord-280642-cvxni7cd 251 12 with with IN cord-280642-cvxni7cd 251 13 time time NN cord-280642-cvxni7cd 251 14 , , , cord-280642-cvxni7cd 251 15 and and CC cord-280642-cvxni7cd 251 16 using use VBG cord-280642-cvxni7cd 251 17 accelerated accelerate VBN cord-280642-cvxni7cd 251 18 failure failure NN cord-280642-cvxni7cd 251 19 time time NN cord-280642-cvxni7cd 251 20 models model NNS cord-280642-cvxni7cd 251 21 , , , cord-280642-cvxni7cd 251 22 to to TO cord-280642-cvxni7cd 251 23 further further RB cord-280642-cvxni7cd 251 24 explore explore VB cord-280642-cvxni7cd 251 25 changes change NNS cord-280642-cvxni7cd 251 26 before before IN cord-280642-cvxni7cd 251 27 and and CC cord-280642-cvxni7cd 251 28 after after IN cord-280642-cvxni7cd 251 29 national national JJ cord-280642-cvxni7cd 251 30 initiatives initiative NNS cord-280642-cvxni7cd 251 31 around around IN cord-280642-cvxni7cd 251 32 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 251 33 . . . cord-280642-cvxni7cd 252 1 Our -PRON- PRP$ cord-280642-cvxni7cd 252 2 findings finding NNS cord-280642-cvxni7cd 252 3 on on IN cord-280642-cvxni7cd 252 4 age age NN cord-280642-cvxni7cd 252 5 and and CC cord-280642-cvxni7cd 252 6 gender gender NN cord-280642-cvxni7cd 252 7 are be VBP cord-280642-cvxni7cd 252 8 consistent consistent JJ cord-280642-cvxni7cd 252 9 with with IN cord-280642-cvxni7cd 252 10 patterns pattern NNS cord-280642-cvxni7cd 252 11 observed observe VBN cord-280642-cvxni7cd 252 12 worldwide worldwide RB cord-280642-cvxni7cd 252 13 in in IN cord-280642-cvxni7cd 252 14 smaller small JJR cord-280642-cvxni7cd 252 15 studies study NNS cord-280642-cvxni7cd 252 16 on on IN cord-280642-cvxni7cd 252 17 patients patient NNS cord-280642-cvxni7cd 252 18 infected infect VBN cord-280642-cvxni7cd 252 19 and/or and/or CC cord-280642-cvxni7cd 252 20 dying die VBG cord-280642-cvxni7cd 252 21 from from IN cord-280642-cvxni7cd 252 22 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 252 23 . . . cord-280642-cvxni7cd 253 1 Compared compare VBN cord-280642-cvxni7cd 253 2 to to IN cord-280642-cvxni7cd 253 3 white white JJ cord-280642-cvxni7cd 253 4 people people NNS cord-280642-cvxni7cd 253 5 , , , cord-280642-cvxni7cd 253 6 people people NNS cord-280642-cvxni7cd 253 7 of of IN cord-280642-cvxni7cd 253 8 Asian asian JJ cord-280642-cvxni7cd 253 9 and and CC cord-280642-cvxni7cd 253 10 Black black JJ cord-280642-cvxni7cd 253 11 ethnic ethnic JJ cord-280642-cvxni7cd 253 12 origin origin NN cord-280642-cvxni7cd 253 13 were be VBD cord-280642-cvxni7cd 253 14 found find VBN cord-280642-cvxni7cd 253 15 to to TO cord-280642-cvxni7cd 253 16 be be VB cord-280642-cvxni7cd 253 17 at at IN cord-280642-cvxni7cd 253 18 . . . cord-280642-cvxni7cd 254 1 CC CC NNP cord-280642-cvxni7cd 254 2 - - : cord-280642-cvxni7cd 254 3 BY by IN cord-280642-cvxni7cd 254 4 4.0 4.0 CD cord-280642-cvxni7cd 254 5 International international JJ cord-280642-cvxni7cd 254 6 license license NN cord-280642-cvxni7cd 255 1 It -PRON- PRP cord-280642-cvxni7cd 255 2 is be VBZ cord-280642-cvxni7cd 255 3 made make VBN cord-280642-cvxni7cd 255 4 available available JJ cord-280642-cvxni7cd 255 5 under under IN cord-280642-cvxni7cd 255 6 a a DT cord-280642-cvxni7cd 256 1 is be VBZ cord-280642-cvxni7cd 256 2 the the DT cord-280642-cvxni7cd 256 3 author author NN cord-280642-cvxni7cd 256 4 / / SYM cord-280642-cvxni7cd 256 5 funder funder NN cord-280642-cvxni7cd 256 6 , , , cord-280642-cvxni7cd 256 7 who who WP cord-280642-cvxni7cd 256 8 has have VBZ cord-280642-cvxni7cd 256 9 granted grant VBN cord-280642-cvxni7cd 256 10 medRxiv medRxiv NNS cord-280642-cvxni7cd 256 11 a a DT cord-280642-cvxni7cd 256 12 license license NN cord-280642-cvxni7cd 256 13 to to TO cord-280642-cvxni7cd 256 14 display display VB cord-280642-cvxni7cd 256 15 the the DT cord-280642-cvxni7cd 256 16 preprint preprint NN cord-280642-cvxni7cd 256 17 in in IN cord-280642-cvxni7cd 256 18 perpetuity perpetuity NN cord-280642-cvxni7cd 256 19 . . . cord-280642-cvxni7cd 257 1 The the DT cord-280642-cvxni7cd 257 2 copyright copyright NN cord-280642-cvxni7cd 257 3 holder holder NN cord-280642-cvxni7cd 257 4 for for IN cord-280642-cvxni7cd 257 5 this this DT cord-280642-cvxni7cd 257 6 preprint preprint NN cord-280642-cvxni7cd 257 7 this this DT cord-280642-cvxni7cd 257 8 version version NN cord-280642-cvxni7cd 257 9 posted post VBN cord-280642-cvxni7cd 257 10 May May NNP cord-280642-cvxni7cd 257 11 7 7 CD cord-280642-cvxni7cd 257 12 , , , cord-280642-cvxni7cd 257 13 2020 2020 CD cord-280642-cvxni7cd 257 14 . . . cord-280642-cvxni7cd 257 15 . . . cord-280642-cvxni7cd 258 1 https://doi.org/10.1101/2020.05.06.20092999 https://doi.org/10.1101/2020.05.06.20092999 NNP cord-280642-cvxni7cd 258 2 doi doi NNP cord-280642-cvxni7cd 258 3 : : : cord-280642-cvxni7cd 259 1 medRxiv medRxiv NNP cord-280642-cvxni7cd 259 2 preprint preprint NNP cord-280642-cvxni7cd 259 3 a a DT cord-280642-cvxni7cd 259 4 higher high JJR cord-280642-cvxni7cd 259 5 risk risk NN cord-280642-cvxni7cd 259 6 of of IN cord-280642-cvxni7cd 259 7 death death NN cord-280642-cvxni7cd 259 8 . . . cord-280642-cvxni7cd 260 1 Non non JJ cord-280642-cvxni7cd 260 2 - - JJ cord-280642-cvxni7cd 260 3 white white JJ cord-280642-cvxni7cd 260 4 ethnicity ethnicity NN cord-280642-cvxni7cd 260 5 has have VBZ cord-280642-cvxni7cd 260 6 previously previously RB cord-280642-cvxni7cd 260 7 been be VBN cord-280642-cvxni7cd 260 8 found find VBN cord-280642-cvxni7cd 260 9 to to TO cord-280642-cvxni7cd 260 10 be be VB cord-280642-cvxni7cd 260 11 associated associate VBN cord-280642-cvxni7cd 260 12 with with IN cord-280642-cvxni7cd 260 13 increased increase VBN cord-280642-cvxni7cd 260 14 COVID-19 covid-19 JJ cord-280642-cvxni7cd 260 15 infection infection NN cord-280642-cvxni7cd 260 16 and and CC cord-280642-cvxni7cd 260 17 poor poor JJ cord-280642-cvxni7cd 260 18 outcomes outcome NNS cord-280642-cvxni7cd 260 19 . . . cord-280642-cvxni7cd 261 1 12 12 CD cord-280642-cvxni7cd 261 2 , , , cord-280642-cvxni7cd 261 3 13 13 CD cord-280642-cvxni7cd 261 4 , , , cord-280642-cvxni7cd 261 5 46 46 CD cord-280642-cvxni7cd 261 6 Commentators commentator NNS cord-280642-cvxni7cd 261 7 and and CC cord-280642-cvxni7cd 261 8 researchers researcher NNS cord-280642-cvxni7cd 261 9 have have VBP cord-280642-cvxni7cd 261 10 reasonably reasonably RB cord-280642-cvxni7cd 261 11 speculated speculate VBN cord-280642-cvxni7cd 261 12 that that IN cord-280642-cvxni7cd 261 13 this this DT cord-280642-cvxni7cd 261 14 might may MD cord-280642-cvxni7cd 261 15 be be VB cord-280642-cvxni7cd 261 16 due due JJ cord-280642-cvxni7cd 261 17 to to IN cord-280642-cvxni7cd 261 18 higher high JJR cord-280642-cvxni7cd 261 19 prevalence prevalence NN cord-280642-cvxni7cd 261 20 of of IN cord-280642-cvxni7cd 261 21 medical medical JJ cord-280642-cvxni7cd 261 22 problems problem NNS cord-280642-cvxni7cd 261 23 such such JJ cord-280642-cvxni7cd 261 24 as as IN cord-280642-cvxni7cd 261 25 cardiovascular cardiovascular JJ cord-280642-cvxni7cd 261 26 disease disease NN cord-280642-cvxni7cd 261 27 or or CC cord-280642-cvxni7cd 261 28 diabetes diabetes NN cord-280642-cvxni7cd 261 29 among among IN cord-280642-cvxni7cd 261 30 BME BME NNP cord-280642-cvxni7cd 261 31 people people NNS cord-280642-cvxni7cd 261 32 , , , cord-280642-cvxni7cd 261 33 or or CC cord-280642-cvxni7cd 261 34 higher high JJR cord-280642-cvxni7cd 261 35 deprivation deprivation NN cord-280642-cvxni7cd 261 36 . . . cord-280642-cvxni7cd 262 1 Our -PRON- PRP$ cord-280642-cvxni7cd 262 2 findings finding NNS cord-280642-cvxni7cd 262 3 , , , cord-280642-cvxni7cd 262 4 based base VBN cord-280642-cvxni7cd 262 5 on on IN cord-280642-cvxni7cd 262 6 more more RBR cord-280642-cvxni7cd 262 7 detailed detailed JJ cord-280642-cvxni7cd 262 8 data datum NNS cord-280642-cvxni7cd 262 9 , , , cord-280642-cvxni7cd 262 10 show show VBP cord-280642-cvxni7cd 262 11 that that IN cord-280642-cvxni7cd 262 12 this this DT cord-280642-cvxni7cd 262 13 is be VBZ cord-280642-cvxni7cd 262 14 only only RB cord-280642-cvxni7cd 262 15 a a DT cord-280642-cvxni7cd 262 16 small small JJ cord-280642-cvxni7cd 262 17 part part NN cord-280642-cvxni7cd 262 18 of of IN cord-280642-cvxni7cd 262 19 the the DT cord-280642-cvxni7cd 262 20 excess excess JJ cord-280642-cvxni7cd 262 21 risk risk NN cord-280642-cvxni7cd 262 22 . . . cord-280642-cvxni7cd 263 1 Other other JJ cord-280642-cvxni7cd 263 2 possible possible JJ cord-280642-cvxni7cd 263 3 explanations explanation NNS cord-280642-cvxni7cd 263 4 for for IN cord-280642-cvxni7cd 263 5 increased increase VBN cord-280642-cvxni7cd 263 6 risk risk NN cord-280642-cvxni7cd 263 7 among among IN cord-280642-cvxni7cd 263 8 BME BME NNP cord-280642-cvxni7cd 263 9 groups group NNS cord-280642-cvxni7cd 263 10 relate relate VBP cord-280642-cvxni7cd 263 11 to to IN cord-280642-cvxni7cd 263 12 higher high JJR cord-280642-cvxni7cd 263 13 infection infection NN cord-280642-cvxni7cd 263 14 risk risk NN cord-280642-cvxni7cd 263 15 , , , cord-280642-cvxni7cd 263 16 including include VBG cord-280642-cvxni7cd 263 17 over over IN cord-280642-cvxni7cd 263 18 - - HYPH cord-280642-cvxni7cd 263 19 representation representation NN cord-280642-cvxni7cd 263 20 in in IN cord-280642-cvxni7cd 263 21 ' ' `` cord-280642-cvxni7cd 263 22 front front JJ cord-280642-cvxni7cd 263 23 - - HYPH cord-280642-cvxni7cd 263 24 line line NN cord-280642-cvxni7cd 263 25 " " '' cord-280642-cvxni7cd 263 26 professions profession NNS cord-280642-cvxni7cd 263 27 with with IN cord-280642-cvxni7cd 263 28 higher high JJR cord-280642-cvxni7cd 263 29 exposure exposure NN cord-280642-cvxni7cd 263 30 to to IN cord-280642-cvxni7cd 263 31 infection infection NN cord-280642-cvxni7cd 263 32 , , , cord-280642-cvxni7cd 263 33 or or CC cord-280642-cvxni7cd 263 34 higher high JJR cord-280642-cvxni7cd 263 35 household household NN cord-280642-cvxni7cd 263 36 density density NN cord-280642-cvxni7cd 263 37 . . . cord-280642-cvxni7cd 264 1 Addressing address VBG cord-280642-cvxni7cd 264 2 these these DT cord-280642-cvxni7cd 264 3 questions question NNS cord-280642-cvxni7cd 264 4 will will MD cord-280642-cvxni7cd 264 5 likely likely RB cord-280642-cvxni7cd 264 6 entail entail VB cord-280642-cvxni7cd 264 7 bespoke bespoke JJ cord-280642-cvxni7cd 264 8 data data NN cord-280642-cvxni7cd 264 9 collection collection NN cord-280642-cvxni7cd 264 10 on on IN cord-280642-cvxni7cd 264 11 , , , cord-280642-cvxni7cd 264 12 for for IN cord-280642-cvxni7cd 264 13 example example NN cord-280642-cvxni7cd 264 14 , , , cord-280642-cvxni7cd 264 15 occupation occupation NN cord-280642-cvxni7cd 264 16 among among IN cord-280642-cvxni7cd 264 17 cases case NNS cord-280642-cvxni7cd 264 18 and and CC cord-280642-cvxni7cd 264 19 controls control NNS cord-280642-cvxni7cd 264 20 . . . cord-280642-cvxni7cd 265 1 We -PRON- PRP cord-280642-cvxni7cd 265 2 also also RB cord-280642-cvxni7cd 265 3 found find VBD cord-280642-cvxni7cd 265 4 a a DT cord-280642-cvxni7cd 265 5 consistent consistent JJ cord-280642-cvxni7cd 265 6 pattern pattern NN cord-280642-cvxni7cd 265 7 of of IN cord-280642-cvxni7cd 265 8 increasing increase VBG cord-280642-cvxni7cd 265 9 risk risk NN cord-280642-cvxni7cd 265 10 with with IN cord-280642-cvxni7cd 265 11 greater great JJR cord-280642-cvxni7cd 265 12 deprivation deprivation NN cord-280642-cvxni7cd 265 13 , , , cord-280642-cvxni7cd 265 14 with with IN cord-280642-cvxni7cd 265 15 the the DT cord-280642-cvxni7cd 265 16 most most RBS cord-280642-cvxni7cd 265 17 deprived deprived JJ cord-280642-cvxni7cd 265 18 quintile quintile NN cord-280642-cvxni7cd 265 19 having have VBG cord-280642-cvxni7cd 265 20 a a DT cord-280642-cvxni7cd 265 21 HR hr NN cord-280642-cvxni7cd 265 22 of of IN cord-280642-cvxni7cd 265 23 1.75 1.75 CD cord-280642-cvxni7cd 265 24 compared compare VBN cord-280642-cvxni7cd 265 25 to to IN cord-280642-cvxni7cd 265 26 the the DT cord-280642-cvxni7cd 265 27 least least JJS cord-280642-cvxni7cd 265 28 deprived deprive VBN cord-280642-cvxni7cd 265 29 , , , cord-280642-cvxni7cd 265 30 consistent consistent JJ cord-280642-cvxni7cd 265 31 with with IN cord-280642-cvxni7cd 265 32 recent recent JJ cord-280642-cvxni7cd 265 33 national national JJ cord-280642-cvxni7cd 265 34 statistics statistic NNS cord-280642-cvxni7cd 265 35 . . . cord-280642-cvxni7cd 266 1 47 47 CD cord-280642-cvxni7cd 267 1 Again again RB cord-280642-cvxni7cd 267 2 , , , cord-280642-cvxni7cd 267 3 contrary contrary JJ cord-280642-cvxni7cd 267 4 to to IN cord-280642-cvxni7cd 267 5 prior prior JJ cord-280642-cvxni7cd 267 6 speculation speculation NN cord-280642-cvxni7cd 267 7 , , , cord-280642-cvxni7cd 267 8 very very RB cord-280642-cvxni7cd 267 9 little little JJ cord-280642-cvxni7cd 267 10 of of IN cord-280642-cvxni7cd 267 11 the the DT cord-280642-cvxni7cd 267 12 increased increase VBN cord-280642-cvxni7cd 267 13 risk risk NN cord-280642-cvxni7cd 267 14 associated associate VBN cord-280642-cvxni7cd 267 15 with with IN cord-280642-cvxni7cd 267 16 deprivation deprivation NN cord-280642-cvxni7cd 267 17 was be VBD cord-280642-cvxni7cd 267 18 explained explain VBN cord-280642-cvxni7cd 267 19 by by IN cord-280642-cvxni7cd 267 20 pre pre JJ cord-280642-cvxni7cd 267 21 - - JJ cord-280642-cvxni7cd 267 22 existing existing JJ cord-280642-cvxni7cd 267 23 disease disease NN cord-280642-cvxni7cd 267 24 or or CC cord-280642-cvxni7cd 267 25 clinical clinical JJ cord-280642-cvxni7cd 267 26 risk risk NN cord-280642-cvxni7cd 267 27 factors factor NNS cord-280642-cvxni7cd 267 28 , , , cord-280642-cvxni7cd 267 29 suggesting suggest VBG cord-280642-cvxni7cd 267 30 that that IN cord-280642-cvxni7cd 267 31 other other JJ cord-280642-cvxni7cd 267 32 social social JJ cord-280642-cvxni7cd 267 33 factors factor NNS cord-280642-cvxni7cd 267 34 increase increase VBP cord-280642-cvxni7cd 267 35 the the DT cord-280642-cvxni7cd 267 36 risk risk NN cord-280642-cvxni7cd 267 37 of of IN cord-280642-cvxni7cd 267 38 COVID-19 covid-19 JJ cord-280642-cvxni7cd 267 39 infection infection NN cord-280642-cvxni7cd 267 40 or or CC cord-280642-cvxni7cd 267 41 death death NN cord-280642-cvxni7cd 267 42 from from IN cord-280642-cvxni7cd 267 43 infection infection NN cord-280642-cvxni7cd 267 44 . . . cord-280642-cvxni7cd 268 1 We -PRON- PRP cord-280642-cvxni7cd 268 2 found find VBD cord-280642-cvxni7cd 268 3 increased increase VBN cord-280642-cvxni7cd 268 4 risk risk NN cord-280642-cvxni7cd 268 5 for for IN cord-280642-cvxni7cd 268 6 the the DT cord-280642-cvxni7cd 268 7 major major JJ cord-280642-cvxni7cd 268 8 included include VBN cord-280642-cvxni7cd 268 9 co co NN cord-280642-cvxni7cd 268 10 - - NNS cord-280642-cvxni7cd 268 11 morbidities morbidity NNS cord-280642-cvxni7cd 268 12 . . . cord-280642-cvxni7cd 269 1 The the DT cord-280642-cvxni7cd 269 2 ISARIC ISARIC NNP cord-280642-cvxni7cd 269 3 study study NN cord-280642-cvxni7cd 269 4 describing describe VBG cord-280642-cvxni7cd 269 5 16,749 16,749 CD cord-280642-cvxni7cd 269 6 hospitalised hospitalise VBN cord-280642-cvxni7cd 269 7 UK UK NNP cord-280642-cvxni7cd 269 8 patients patient NNS cord-280642-cvxni7cd 269 9 with with IN cord-280642-cvxni7cd 269 10 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 269 11 also also RB cord-280642-cvxni7cd 269 12 indicated indicate VBD cord-280642-cvxni7cd 269 13 increased increased JJ cord-280642-cvxni7cd 269 14 risk risk NN cord-280642-cvxni7cd 269 15 of of IN cord-280642-cvxni7cd 269 16 death death NN cord-280642-cvxni7cd 269 17 among among IN cord-280642-cvxni7cd 269 18 hospitalised hospitalise VBN cord-280642-cvxni7cd 269 19 patients patient NNS cord-280642-cvxni7cd 269 20 with with IN cord-280642-cvxni7cd 269 21 cardiac cardiac JJ cord-280642-cvxni7cd 269 22 , , , cord-280642-cvxni7cd 269 23 pulmonary pulmonary JJ cord-280642-cvxni7cd 269 24 and and CC cord-280642-cvxni7cd 269 25 kidney kidney NN cord-280642-cvxni7cd 269 26 disease disease NN cord-280642-cvxni7cd 269 27 , , , cord-280642-cvxni7cd 269 28 malignancy malignancy NN cord-280642-cvxni7cd 269 29 and and CC cord-280642-cvxni7cd 269 30 dementia dementia NN cord-280642-cvxni7cd 269 31 . . . cord-280642-cvxni7cd 270 1 6 6 CD cord-280642-cvxni7cd 270 2 Cardiovascular cardiovascular JJ cord-280642-cvxni7cd 270 3 disease disease NN cord-280642-cvxni7cd 270 4 , , , cord-280642-cvxni7cd 270 5 hypertension hypertension NN cord-280642-cvxni7cd 270 6 , , , cord-280642-cvxni7cd 270 7 diabetes diabetes NN cord-280642-cvxni7cd 270 8 , , , cord-280642-cvxni7cd 270 9 respiratory respiratory JJ cord-280642-cvxni7cd 270 10 disease disease NN cord-280642-cvxni7cd 270 11 , , , cord-280642-cvxni7cd 270 12 and and CC cord-280642-cvxni7cd 270 13 cancers cancer NNS cord-280642-cvxni7cd 270 14 were be VBD cord-280642-cvxni7cd 270 15 all all DT cord-280642-cvxni7cd 270 16 associated associate VBN cord-280642-cvxni7cd 270 17 with with IN cord-280642-cvxni7cd 270 18 increased increase VBN cord-280642-cvxni7cd 270 19 risk risk NN cord-280642-cvxni7cd 270 20 of of IN cord-280642-cvxni7cd 270 21 death death NN cord-280642-cvxni7cd 270 22 in in IN cord-280642-cvxni7cd 270 23 a a DT cord-280642-cvxni7cd 270 24 large large JJ cord-280642-cvxni7cd 270 25 Chinese chinese JJ cord-280642-cvxni7cd 270 26 study study NN cord-280642-cvxni7cd 270 27 describing describe VBG cord-280642-cvxni7cd 270 28 44,672 44,672 CD cord-280642-cvxni7cd 270 29 confirmed confirm VBN cord-280642-cvxni7cd 270 30 cases case NNS cord-280642-cvxni7cd 270 31 , , , cord-280642-cvxni7cd 270 32 but but CC cord-280642-cvxni7cd 270 33 which which WDT cord-280642-cvxni7cd 270 34 lacked lack VBD cord-280642-cvxni7cd 270 35 age age NN cord-280642-cvxni7cd 270 36 - - HYPH cord-280642-cvxni7cd 270 37 correction correction NN cord-280642-cvxni7cd 270 38 . . . cord-280642-cvxni7cd 271 1 5 5 CD cord-280642-cvxni7cd 271 2 Of of IN cord-280642-cvxni7cd 271 3 particular particular JJ cord-280642-cvxni7cd 271 4 note note NN cord-280642-cvxni7cd 271 5 in in IN cord-280642-cvxni7cd 271 6 our -PRON- PRP$ cord-280642-cvxni7cd 271 7 results result NNS cord-280642-cvxni7cd 271 8 is be VBZ cord-280642-cvxni7cd 271 9 the the DT cord-280642-cvxni7cd 271 10 association association NN cord-280642-cvxni7cd 271 11 of of IN cord-280642-cvxni7cd 271 12 asthma asthma NNP cord-280642-cvxni7cd 271 13 with with IN cord-280642-cvxni7cd 271 14 higher high JJR cord-280642-cvxni7cd 271 15 risk risk NN cord-280642-cvxni7cd 271 16 of of IN cord-280642-cvxni7cd 271 17 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 271 18 hospital hospital NN cord-280642-cvxni7cd 271 19 death death NN cord-280642-cvxni7cd 271 20 , , , cord-280642-cvxni7cd 271 21 with with IN cord-280642-cvxni7cd 271 22 the the DT cord-280642-cvxni7cd 271 23 HR hr NN cord-280642-cvxni7cd 271 24 increasing increase VBG cord-280642-cvxni7cd 271 25 further far RBR cord-280642-cvxni7cd 271 26 for for IN cord-280642-cvxni7cd 271 27 those those DT cord-280642-cvxni7cd 271 28 having have VBG cord-280642-cvxni7cd 271 29 a a DT cord-280642-cvxni7cd 271 30 recent recent JJ cord-280642-cvxni7cd 271 31 oral oral JJ cord-280642-cvxni7cd 271 32 corticosteroid corticosteroid NN cord-280642-cvxni7cd 271 33 ( ( -LRB- cord-280642-cvxni7cd 271 34 indicating indicate VBG cord-280642-cvxni7cd 271 35 greater great JJR cord-280642-cvxni7cd 271 36 severity severity NN cord-280642-cvxni7cd 271 37 of of IN cord-280642-cvxni7cd 271 38 disease disease NN cord-280642-cvxni7cd 271 39 ) ) -RRB- cord-280642-cvxni7cd 271 40 . . . cord-280642-cvxni7cd 272 1 This this DT cord-280642-cvxni7cd 272 2 contrasts contrast VBZ cord-280642-cvxni7cd 272 3 with with IN cord-280642-cvxni7cd 272 4 previous previous JJ cord-280642-cvxni7cd 272 5 findings finding NNS cord-280642-cvxni7cd 272 6 : : : cord-280642-cvxni7cd 272 7 in in IN cord-280642-cvxni7cd 272 8 several several JJ cord-280642-cvxni7cd 272 9 countries country NNS cord-280642-cvxni7cd 272 10 , , , cord-280642-cvxni7cd 272 11 asthma asthma NN cord-280642-cvxni7cd 272 12 and and CC cord-280642-cvxni7cd 272 13 other other JJ cord-280642-cvxni7cd 272 14 chronic chronic JJ cord-280642-cvxni7cd 272 15 respiratory respiratory JJ cord-280642-cvxni7cd 272 16 diseases disease NNS cord-280642-cvxni7cd 272 17 are be VBP cord-280642-cvxni7cd 272 18 underrepresented underrepresente VBN cord-280642-cvxni7cd 272 19 in in IN cord-280642-cvxni7cd 272 20 hospitalised hospitalise VBN cord-280642-cvxni7cd 272 21 patients patient NNS cord-280642-cvxni7cd 272 22 ; ; : cord-280642-cvxni7cd 272 23 48 48 CD cord-280642-cvxni7cd 272 24 and and CC cord-280642-cvxni7cd 272 25 among among IN cord-280642-cvxni7cd 272 26 the the DT cord-280642-cvxni7cd 272 27 first first JJ cord-280642-cvxni7cd 272 28 few few JJ cord-280642-cvxni7cd 272 29 hundred hundred CD cord-280642-cvxni7cd 272 30 cases case NNS cord-280642-cvxni7cd 272 31 in in IN cord-280642-cvxni7cd 272 32 UK UK NNP cord-280642-cvxni7cd 272 33 , , , cord-280642-cvxni7cd 272 34 a a DT cord-280642-cvxni7cd 272 35 protective protective JJ cord-280642-cvxni7cd 272 36 association association NN cord-280642-cvxni7cd 272 37 with with IN cord-280642-cvxni7cd 272 38 asthma asthma NN cord-280642-cvxni7cd 272 39 was be VBD cord-280642-cvxni7cd 272 40 observed observe VBN cord-280642-cvxni7cd 272 41 , , , cord-280642-cvxni7cd 272 42 although although IN cord-280642-cvxni7cd 272 43 presence presence NN cord-280642-cvxni7cd 272 44 of of IN cord-280642-cvxni7cd 272 45 asthma asthma NN cord-280642-cvxni7cd 272 46 was be VBD cord-280642-cvxni7cd 272 47 ascertained ascertain VBN cord-280642-cvxni7cd 272 48 differently differently RB cord-280642-cvxni7cd 272 49 for for IN cord-280642-cvxni7cd 272 50 cases case NNS cord-280642-cvxni7cd 272 51 and and CC cord-280642-cvxni7cd 272 52 controls control NNS cord-280642-cvxni7cd 272 53 which which WDT cord-280642-cvxni7cd 272 54 could could MD cord-280642-cvxni7cd 272 55 be be VB cord-280642-cvxni7cd 272 56 a a DT cord-280642-cvxni7cd 272 57 source source NN cord-280642-cvxni7cd 272 58 of of IN cord-280642-cvxni7cd 272 59 bias bias NN cord-280642-cvxni7cd 272 60 . . . cord-280642-cvxni7cd 273 1 36 36 CD cord-280642-cvxni7cd 274 1 The the DT cord-280642-cvxni7cd 274 2 ISARIC ISARIC NNP cord-280642-cvxni7cd 274 3 study study NN cord-280642-cvxni7cd 274 4 reported report VBD cord-280642-cvxni7cd 274 5 14 14 CD cord-280642-cvxni7cd 274 6 % % NN cord-280642-cvxni7cd 274 7 of of IN cord-280642-cvxni7cd 274 8 hospitalised hospitalise VBN cord-280642-cvxni7cd 274 9 patients patient NNS cord-280642-cvxni7cd 274 10 having have VBG cord-280642-cvxni7cd 274 11 asthma asthma NN cord-280642-cvxni7cd 274 12 but but CC cord-280642-cvxni7cd 274 13 no no DT cord-280642-cvxni7cd 274 14 increased increase VBN cord-280642-cvxni7cd 274 15 risk risk NN cord-280642-cvxni7cd 274 16 of of IN cord-280642-cvxni7cd 274 17 death death NN cord-280642-cvxni7cd 274 18 . . . cord-280642-cvxni7cd 275 1 6 6 CD cord-280642-cvxni7cd 276 1 However however RB cord-280642-cvxni7cd 276 2 , , , cord-280642-cvxni7cd 276 3 in in IN cord-280642-cvxni7cd 276 4 both both CC cord-280642-cvxni7cd 276 5 the the DT cord-280642-cvxni7cd 276 6 UK UK NNP cord-280642-cvxni7cd 276 7 and and CC cord-280642-cvxni7cd 276 8 China China NNP cord-280642-cvxni7cd 276 9 , , , cord-280642-cvxni7cd 276 10 COPD COPD NNP cord-280642-cvxni7cd 276 11 did do VBD cord-280642-cvxni7cd 276 12 appear appear VB cord-280642-cvxni7cd 276 13 to to TO cord-280642-cvxni7cd 276 14 confer confer VB cord-280642-cvxni7cd 276 15 increased increase VBN cord-280642-cvxni7cd 276 16 risk risk NN cord-280642-cvxni7cd 276 17 of of IN cord-280642-cvxni7cd 276 18 death death NN cord-280642-cvxni7cd 276 19 among among IN cord-280642-cvxni7cd 276 20 hospitalised hospitalise VBN cord-280642-cvxni7cd 276 21 or or CC cord-280642-cvxni7cd 276 22 confirmed confirm VBN cord-280642-cvxni7cd 276 23 cases case NNS cord-280642-cvxni7cd 276 24 , , , cord-280642-cvxni7cd 276 25 respectively respectively RB cord-280642-cvxni7cd 276 26 . . . cord-280642-cvxni7cd 277 1 5 5 CD cord-280642-cvxni7cd 277 2 , , , cord-280642-cvxni7cd 277 3 6 6 CD cord-280642-cvxni7cd 278 1 Our -PRON- PRP$ cord-280642-cvxni7cd 278 2 study study NN cord-280642-cvxni7cd 278 3 design design NN cord-280642-cvxni7cd 278 4 combines combine VBZ cord-280642-cvxni7cd 278 5 both both DT cord-280642-cvxni7cd 278 6 risk risk NN cord-280642-cvxni7cd 278 7 of of IN cord-280642-cvxni7cd 278 8 infection infection NN cord-280642-cvxni7cd 278 9 and and CC cord-280642-cvxni7cd 278 10 risk risk NN cord-280642-cvxni7cd 278 11 of of IN cord-280642-cvxni7cd 278 12 death death NN cord-280642-cvxni7cd 278 13 once once RB cord-280642-cvxni7cd 278 14 infected infect VBN cord-280642-cvxni7cd 278 15 ; ; : cord-280642-cvxni7cd 278 16 it -PRON- PRP cord-280642-cvxni7cd 278 17 is be VBZ cord-280642-cvxni7cd 278 18 also also RB cord-280642-cvxni7cd 278 19 possible possible JJ cord-280642-cvxni7cd 278 20 that that IN cord-280642-cvxni7cd 278 21 our -PRON- PRP$ cord-280642-cvxni7cd 278 22 methodology methodology NN cord-280642-cvxni7cd 278 23 captured capture VBD cord-280642-cvxni7cd 278 24 more more JJR cord-280642-cvxni7cd 278 25 people people NNS cord-280642-cvxni7cd 278 26 with with IN cord-280642-cvxni7cd 278 27 asthma asthma NN cord-280642-cvxni7cd 278 28 and and CC cord-280642-cvxni7cd 278 29 was be VBD cord-280642-cvxni7cd 278 30 better well RBR cord-280642-cvxni7cd 278 31 able able JJ cord-280642-cvxni7cd 278 32 to to TO cord-280642-cvxni7cd 278 33 delineate delineate VB cord-280642-cvxni7cd 278 34 more more RBR cord-280642-cvxni7cd 278 35 severe severe JJ cord-280642-cvxni7cd 278 36 asthma asthma NN cord-280642-cvxni7cd 278 37 than than IN cord-280642-cvxni7cd 278 38 previous previous JJ cord-280642-cvxni7cd 278 39 studies study NNS cord-280642-cvxni7cd 278 40 based base VBN cord-280642-cvxni7cd 278 41 on on IN cord-280642-cvxni7cd 278 42 hospital hospital NN cord-280642-cvxni7cd 278 43 records record NNS cord-280642-cvxni7cd 278 44 . . . cord-280642-cvxni7cd 279 1 We -PRON- PRP cord-280642-cvxni7cd 279 2 found find VBD cord-280642-cvxni7cd 279 3 no no DT cord-280642-cvxni7cd 279 4 association association NN cord-280642-cvxni7cd 279 5 between between IN cord-280642-cvxni7cd 279 6 hypertension hypertension NN cord-280642-cvxni7cd 279 7 and and CC cord-280642-cvxni7cd 279 8 death death NN cord-280642-cvxni7cd 279 9 where where WRB cord-280642-cvxni7cd 279 10 hypertension hypertension NN cord-280642-cvxni7cd 279 11 was be VBD cord-280642-cvxni7cd 279 12 defined define VBN cord-280642-cvxni7cd 279 13 as as IN cord-280642-cvxni7cd 279 14 a a DT cord-280642-cvxni7cd 279 15 recorded record VBN cord-280642-cvxni7cd 279 16 diagnosis diagnosis NN cord-280642-cvxni7cd 279 17 or or CC cord-280642-cvxni7cd 279 18 high high JJ cord-280642-cvxni7cd 279 19 blood blood NN cord-280642-cvxni7cd 279 20 pressure pressure NN cord-280642-cvxni7cd 279 21 at at IN cord-280642-cvxni7cd 279 22 last last JJ cord-280642-cvxni7cd 279 23 measurement measurement NN cord-280642-cvxni7cd 279 24 ( ( -LRB- cord-280642-cvxni7cd 279 25 HR HR NNP cord-280642-cvxni7cd 279 26 0.96 0.96 CD cord-280642-cvxni7cd 279 27 , , , cord-280642-cvxni7cd 279 28 0.9 0.9 CD cord-280642-cvxni7cd 279 29 - - SYM cord-280642-cvxni7cd 279 30 1.02 1.02 CD cord-280642-cvxni7cd 279 31 ) ) -RRB- cord-280642-cvxni7cd 279 32 . . . cord-280642-cvxni7cd 280 1 However however RB cord-280642-cvxni7cd 280 2 when when WRB cord-280642-cvxni7cd 280 3 separated separate VBN cord-280642-cvxni7cd 280 4 out out RP cord-280642-cvxni7cd 280 5 in in IN cord-280642-cvxni7cd 280 6 sensitivity sensitivity NN cord-280642-cvxni7cd 280 7 analyses analysis NNS cord-280642-cvxni7cd 281 1 diagnosed diagnosed JJ cord-280642-cvxni7cd 281 2 hypertension hypertension NN cord-280642-cvxni7cd 281 3 was be VBD cord-280642-cvxni7cd 281 4 associated associate VBN cord-280642-cvxni7cd 281 5 with with IN cord-280642-cvxni7cd 281 6 slightly slightly RB cord-280642-cvxni7cd 281 7 increased increase VBN cord-280642-cvxni7cd 281 8 risk risk NN cord-280642-cvxni7cd 281 9 , , , cord-280642-cvxni7cd 281 10 whilst whilst IN cord-280642-cvxni7cd 281 11 a a DT cord-280642-cvxni7cd 281 12 high high JJ cord-280642-cvxni7cd 281 13 blood blood NN cord-280642-cvxni7cd 281 14 pressure pressure NN cord-280642-cvxni7cd 281 15 measurement measurement NN cord-280642-cvxni7cd 281 16 was be VBD cord-280642-cvxni7cd 281 17 associated associate VBN cord-280642-cvxni7cd 281 18 with with IN cord-280642-cvxni7cd 281 19 slightly slightly RB cord-280642-cvxni7cd 281 20 reduced reduce VBN cord-280642-cvxni7cd 281 21 risk risk NN cord-280642-cvxni7cd 281 22 . . . cord-280642-cvxni7cd 282 1 Hypertension hypertension NN cord-280642-cvxni7cd 282 2 is be VBZ cord-280642-cvxni7cd 282 3 very very RB cord-280642-cvxni7cd 282 4 strongly strongly RB cord-280642-cvxni7cd 282 5 associated associate VBN cord-280642-cvxni7cd 282 6 with with IN cord-280642-cvxni7cd 282 7 age age NN cord-280642-cvxni7cd 282 8 and and CC cord-280642-cvxni7cd 282 9 although although IN cord-280642-cvxni7cd 282 10 we -PRON- PRP cord-280642-cvxni7cd 282 11 adjusted adjust VBD cord-280642-cvxni7cd 282 12 for for IN cord-280642-cvxni7cd 282 13 this this DT cord-280642-cvxni7cd 282 14 , , , cord-280642-cvxni7cd 282 15 disentangling disentangle VBG cord-280642-cvxni7cd 282 16 the the DT cord-280642-cvxni7cd 282 17 effects effect NNS cord-280642-cvxni7cd 282 18 of of IN cord-280642-cvxni7cd 282 19 each each DT cord-280642-cvxni7cd 282 20 is be VBZ cord-280642-cvxni7cd 282 21 difficult difficult JJ cord-280642-cvxni7cd 282 22 . . . cord-280642-cvxni7cd 283 1 We -PRON- PRP cord-280642-cvxni7cd 283 2 showed show VBD cord-280642-cvxni7cd 283 3 increasing increase VBG cord-280642-cvxni7cd 283 4 risk risk NN cord-280642-cvxni7cd 283 5 of of IN cord-280642-cvxni7cd 283 6 death death NN cord-280642-cvxni7cd 283 7 with with IN cord-280642-cvxni7cd 283 8 degree degree NN cord-280642-cvxni7cd 283 9 of of IN cord-280642-cvxni7cd 283 10 obesity obesity NN cord-280642-cvxni7cd 283 11 : : : cord-280642-cvxni7cd 283 12 fully fully RB cord-280642-cvxni7cd 283 13 - - HYPH cord-280642-cvxni7cd 283 14 adjusted adjust VBN cord-280642-cvxni7cd 283 15 HR hr NN cord-280642-cvxni7cd 283 16 1.27 1.27 CD cord-280642-cvxni7cd 283 17 for for IN cord-280642-cvxni7cd 283 18 BMI BMI NNP cord-280642-cvxni7cd 283 19 30 30 CD cord-280642-cvxni7cd 283 20 - - SYM cord-280642-cvxni7cd 283 21 34.9 34.9 CD cord-280642-cvxni7cd 283 22 kg kg NNS cord-280642-cvxni7cd 283 23 / / SYM cord-280642-cvxni7cd 283 24 m m NN cord-280642-cvxni7cd 283 25 2 2 CD cord-280642-cvxni7cd 283 26 , , , cord-280642-cvxni7cd 283 27 increasing increase VBG cord-280642-cvxni7cd 283 28 to to IN cord-280642-cvxni7cd 283 29 2.27 2.27 CD cord-280642-cvxni7cd 283 30 for for IN cord-280642-cvxni7cd 283 31 BMI BMI NNP cord-280642-cvxni7cd 283 32 > > XX cord-280642-cvxni7cd 283 33 = = SYM cord-280642-cvxni7cd 283 34 40 40 CD cord-280642-cvxni7cd 283 35 kg kg NN cord-280642-cvxni7cd 283 36 / / SYM cord-280642-cvxni7cd 283 37 m m NN cord-280642-cvxni7cd 283 38 2 2 CD cord-280642-cvxni7cd 283 39 . . . cord-280642-cvxni7cd 284 1 Previous previous JJ cord-280642-cvxni7cd 284 2 studies study NNS cord-280642-cvxni7cd 284 3 have have VBP cord-280642-cvxni7cd 284 4 shown show VBN cord-280642-cvxni7cd 284 5 increased increase VBN cord-280642-cvxni7cd 284 6 risk risk NN cord-280642-cvxni7cd 284 7 with with IN cord-280642-cvxni7cd 284 8 obesity obesity NN cord-280642-cvxni7cd 284 9 among among IN cord-280642-cvxni7cd 284 10 hospitalised hospitalise VBN cord-280642-cvxni7cd 284 11 patients patient NNS cord-280642-cvxni7cd 284 12 : : : cord-280642-cvxni7cd 284 13 ISARIC ISARIC NNP cord-280642-cvxni7cd 284 14 , , , cord-280642-cvxni7cd 284 15 based base VBN cord-280642-cvxni7cd 284 16 on on IN cord-280642-cvxni7cd 284 17 hospital hospital NN cord-280642-cvxni7cd 284 18 survey survey NN cord-280642-cvxni7cd 284 19 data datum NNS cord-280642-cvxni7cd 284 20 ( ( -LRB- cord-280642-cvxni7cd 284 21 2,212 2,212 CD cord-280642-cvxni7cd 284 22 deaths death NNS cord-280642-cvxni7cd 284 23 ) ) -RRB- cord-280642-cvxni7cd 284 24 , , , cord-280642-cvxni7cd 284 25 found find VBD cord-280642-cvxni7cd 284 26 a a DT cord-280642-cvxni7cd 284 27 HR hr NN cord-280642-cvxni7cd 284 28 of of IN cord-280642-cvxni7cd 284 29 1.37 1.37 CD cord-280642-cvxni7cd 284 30 for for IN cord-280642-cvxni7cd 284 31 death death NN cord-280642-cvxni7cd 284 32 associated associate VBN cord-280642-cvxni7cd 284 33 with with IN cord-280642-cvxni7cd 284 34 clinician clinician NN cord-280642-cvxni7cd 284 35 - - HYPH cord-280642-cvxni7cd 284 36 reported report VBN cord-280642-cvxni7cd 284 37 obesity obesity NN cord-280642-cvxni7cd 284 38 among among IN cord-280642-cvxni7cd 284 39 16,749 16,749 CD cord-280642-cvxni7cd 284 40 hospitalised hospitalise VBN cord-280642-cvxni7cd 284 41 patients patient NNS cord-280642-cvxni7cd 284 42 , , , cord-280642-cvxni7cd 284 43 after after IN cord-280642-cvxni7cd 284 44 age age NN cord-280642-cvxni7cd 284 45 and and CC cord-280642-cvxni7cd 284 46 sex sex NN cord-280642-cvxni7cd 284 47 correction correction NN cord-280642-cvxni7cd 284 48 ( ( -LRB- cord-280642-cvxni7cd 284 49 95 95 CD cord-280642-cvxni7cd 284 50 % % NN cord-280642-cvxni7cd 284 51 CI CI NNP cord-280642-cvxni7cd 284 52 1.16 1.16 CD cord-280642-cvxni7cd 284 53 - - SYM cord-280642-cvxni7cd 284 54 1.63 1.63 CD cord-280642-cvxni7cd 284 55 ) ) -RRB- cord-280642-cvxni7cd 284 56 6 6 CD cord-280642-cvxni7cd 284 57 ; ; , cord-280642-cvxni7cd 284 58 obesity obesity NN cord-280642-cvxni7cd 284 59 was be VBD cord-280642-cvxni7cd 284 60 also also RB cord-280642-cvxni7cd 284 61 reported report VBN cord-280642-cvxni7cd 284 62 as as IN cord-280642-cvxni7cd 284 63 a a DT cord-280642-cvxni7cd 284 64 risk risk NN cord-280642-cvxni7cd 284 65 factor factor NN cord-280642-cvxni7cd 284 66 for for IN cord-280642-cvxni7cd 284 67 treatment treatment NN cord-280642-cvxni7cd 284 68 escalation escalation NN cord-280642-cvxni7cd 284 69 in in IN cord-280642-cvxni7cd 284 70 smaller small JJR cord-280642-cvxni7cd 284 71 studies study NNS cord-280642-cvxni7cd 284 72 in in IN cord-280642-cvxni7cd 284 73 France France NNP cord-280642-cvxni7cd 284 74 and and CC cord-280642-cvxni7cd 284 75 New New NNP cord-280642-cvxni7cd 284 76 York York NNP cord-280642-cvxni7cd 284 77 . . . cord-280642-cvxni7cd 285 1 7 7 CD cord-280642-cvxni7cd 285 2 , , , cord-280642-cvxni7cd 285 3 8 8 CD cord-280642-cvxni7cd 285 4 . . . cord-280642-cvxni7cd 286 1 CC CC NNP cord-280642-cvxni7cd 286 2 - - : cord-280642-cvxni7cd 286 3 BY by IN cord-280642-cvxni7cd 286 4 4.0 4.0 CD cord-280642-cvxni7cd 286 5 International international JJ cord-280642-cvxni7cd 286 6 license license NN cord-280642-cvxni7cd 287 1 It -PRON- PRP cord-280642-cvxni7cd 287 2 is be VBZ cord-280642-cvxni7cd 287 3 made make VBN cord-280642-cvxni7cd 287 4 available available JJ cord-280642-cvxni7cd 287 5 under under IN cord-280642-cvxni7cd 287 6 a a DT cord-280642-cvxni7cd 288 1 is be VBZ cord-280642-cvxni7cd 288 2 the the DT cord-280642-cvxni7cd 288 3 author author NN cord-280642-cvxni7cd 288 4 / / SYM cord-280642-cvxni7cd 288 5 funder funder NN cord-280642-cvxni7cd 288 6 , , , cord-280642-cvxni7cd 288 7 who who WP cord-280642-cvxni7cd 288 8 has have VBZ cord-280642-cvxni7cd 288 9 granted grant VBN cord-280642-cvxni7cd 288 10 medRxiv medRxiv NNS cord-280642-cvxni7cd 288 11 a a DT cord-280642-cvxni7cd 288 12 license license NN cord-280642-cvxni7cd 288 13 to to TO cord-280642-cvxni7cd 288 14 display display VB cord-280642-cvxni7cd 288 15 the the DT cord-280642-cvxni7cd 288 16 preprint preprint NN cord-280642-cvxni7cd 288 17 in in IN cord-280642-cvxni7cd 288 18 perpetuity perpetuity NN cord-280642-cvxni7cd 288 19 . . . cord-280642-cvxni7cd 289 1 The the DT cord-280642-cvxni7cd 289 2 copyright copyright NN cord-280642-cvxni7cd 289 3 holder holder NN cord-280642-cvxni7cd 289 4 for for IN cord-280642-cvxni7cd 289 5 this this DT cord-280642-cvxni7cd 289 6 preprint preprint NN cord-280642-cvxni7cd 289 7 this this DT cord-280642-cvxni7cd 289 8 version version NN cord-280642-cvxni7cd 289 9 posted post VBN cord-280642-cvxni7cd 289 10 May May NNP cord-280642-cvxni7cd 289 11 7 7 CD cord-280642-cvxni7cd 289 12 , , , cord-280642-cvxni7cd 289 13 2020 2020 CD cord-280642-cvxni7cd 289 14 . . . cord-280642-cvxni7cd 290 1 We -PRON- PRP cord-280642-cvxni7cd 290 2 found find VBD cord-280642-cvxni7cd 290 3 some some DT cord-280642-cvxni7cd 290 4 evidence evidence NN cord-280642-cvxni7cd 290 5 of of IN cord-280642-cvxni7cd 290 6 increased increase VBN cord-280642-cvxni7cd 290 7 risks risk NNS cord-280642-cvxni7cd 290 8 in in IN cord-280642-cvxni7cd 290 9 former former JJ cord-280642-cvxni7cd 290 10 smokers smoker NNS cord-280642-cvxni7cd 290 11 . . . cord-280642-cvxni7cd 291 1 In in IN cord-280642-cvxni7cd 291 2 current current JJ cord-280642-cvxni7cd 291 3 smokers smoker NNS cord-280642-cvxni7cd 291 4 there there EX cord-280642-cvxni7cd 291 5 was be VBD cord-280642-cvxni7cd 291 6 a a DT cord-280642-cvxni7cd 291 7 slight slight JJ cord-280642-cvxni7cd 291 8 protective protective JJ cord-280642-cvxni7cd 291 9 effect effect NN cord-280642-cvxni7cd 291 10 , , , cord-280642-cvxni7cd 291 11 which which WDT cord-280642-cvxni7cd 291 12 was be VBD cord-280642-cvxni7cd 291 13 removed remove VBN cord-280642-cvxni7cd 291 14 when when WRB cord-280642-cvxni7cd 291 15 fully fully RB cord-280642-cvxni7cd 291 16 adjusted adjust VBN cord-280642-cvxni7cd 291 17 for for IN cord-280642-cvxni7cd 291 18 ethnicity ethnicity NN cord-280642-cvxni7cd 291 19 . . . cord-280642-cvxni7cd 292 1 The the DT cord-280642-cvxni7cd 292 2 risks risk NNS cord-280642-cvxni7cd 292 3 associated associate VBN cord-280642-cvxni7cd 292 4 with with IN cord-280642-cvxni7cd 292 5 smoking smoking NN cord-280642-cvxni7cd 292 6 have have VBP cord-280642-cvxni7cd 292 7 been be VBN cord-280642-cvxni7cd 292 8 disputed dispute VBN cord-280642-cvxni7cd 292 9 , , , cord-280642-cvxni7cd 292 10 with with IN cord-280642-cvxni7cd 292 11 increased increase VBN cord-280642-cvxni7cd 292 12 risks risk NNS cord-280642-cvxni7cd 292 13 initially initially RB cord-280642-cvxni7cd 292 14 reported report VBD cord-280642-cvxni7cd 292 15 , , , cord-280642-cvxni7cd 292 16 but but CC cord-280642-cvxni7cd 292 17 some some DT cord-280642-cvxni7cd 292 18 more more RBR cord-280642-cvxni7cd 292 19 recent recent JJ cord-280642-cvxni7cd 292 20 reports report NNS cord-280642-cvxni7cd 292 21 finding find VBG cord-280642-cvxni7cd 292 22 that that IN cord-280642-cvxni7cd 292 23 smokers smoker NNS cord-280642-cvxni7cd 292 24 are be VBP cord-280642-cvxni7cd 292 25 under under RB cord-280642-cvxni7cd 292 26 - - HYPH cord-280642-cvxni7cd 292 27 represented represent VBN cord-280642-cvxni7cd 292 28 in in IN cord-280642-cvxni7cd 292 29 those those DT cord-280642-cvxni7cd 292 30 with with IN cord-280642-cvxni7cd 292 31 more more RBR cord-280642-cvxni7cd 292 32 severe severe JJ cord-280642-cvxni7cd 292 33 disease disease NN cord-280642-cvxni7cd 292 34 , , , cord-280642-cvxni7cd 292 35 and and CC cord-280642-cvxni7cd 292 36 a a DT cord-280642-cvxni7cd 292 37 potential potential JJ cord-280642-cvxni7cd 292 38 protective protective JJ cord-280642-cvxni7cd 292 39 mechanism mechanism NN cord-280642-cvxni7cd 292 40 for for IN cord-280642-cvxni7cd 292 41 nicotine nicotine NN cord-280642-cvxni7cd 292 42 has have VBZ cord-280642-cvxni7cd 292 43 been be VBN cord-280642-cvxni7cd 292 44 suggested suggest VBN cord-280642-cvxni7cd 292 45 9,49 9,49 CD cord-280642-cvxni7cd 292 46 : : : cord-280642-cvxni7cd 292 47 smoking smoking NN cord-280642-cvxni7cd 292 48 prevalence prevalence NN cord-280642-cvxni7cd 292 49 was be VBD cord-280642-cvxni7cd 292 50 lower low JJR cord-280642-cvxni7cd 292 51 than than IN cord-280642-cvxni7cd 292 52 expected expect VBN cord-280642-cvxni7cd 292 53 among among IN cord-280642-cvxni7cd 292 54 hospitalised hospitalise VBN cord-280642-cvxni7cd 292 55 patients patient NNS cord-280642-cvxni7cd 292 56 in in IN cord-280642-cvxni7cd 292 57 China China NNP cord-280642-cvxni7cd 292 58 , , , cord-280642-cvxni7cd 292 59 10 10 CD cord-280642-cvxni7cd 292 60 France France NNP cord-280642-cvxni7cd 292 61 11 11 CD cord-280642-cvxni7cd 292 62 and and CC cord-280642-cvxni7cd 292 63 the the DT cord-280642-cvxni7cd 292 64 USA USA NNP cord-280642-cvxni7cd 292 65 . . . cord-280642-cvxni7cd 293 1 50 50 CD cord-280642-cvxni7cd 294 1 Even even RB cord-280642-cvxni7cd 294 2 if if IN cord-280642-cvxni7cd 294 3 smoking smoking NN cord-280642-cvxni7cd 294 4 does do VBZ cord-280642-cvxni7cd 294 5 have have VB cord-280642-cvxni7cd 294 6 a a DT cord-280642-cvxni7cd 294 7 small small JJ cord-280642-cvxni7cd 294 8 protective protective JJ cord-280642-cvxni7cd 294 9 effects effect NNS cord-280642-cvxni7cd 294 10 against against IN cord-280642-cvxni7cd 294 11 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 294 12 , , , cord-280642-cvxni7cd 294 13 this this DT cord-280642-cvxni7cd 294 14 would would MD cord-280642-cvxni7cd 294 15 still still RB cord-280642-cvxni7cd 294 16 be be VB cord-280642-cvxni7cd 294 17 massively massively RB cord-280642-cvxni7cd 294 18 outweighed outweigh VBN cord-280642-cvxni7cd 294 19 by by IN cord-280642-cvxni7cd 294 20 the the DT cord-280642-cvxni7cd 294 21 well well RB cord-280642-cvxni7cd 294 22 - - HYPH cord-280642-cvxni7cd 294 23 established establish VBN cord-280642-cvxni7cd 294 24 adverse adverse JJ cord-280642-cvxni7cd 294 25 health health NN cord-280642-cvxni7cd 294 26 effects effect NNS cord-280642-cvxni7cd 294 27 of of IN cord-280642-cvxni7cd 294 28 smoking smoking NN cord-280642-cvxni7cd 294 29 . . . cord-280642-cvxni7cd 295 1 The the DT cord-280642-cvxni7cd 295 2 UK UK NNP cord-280642-cvxni7cd 295 3 has have VBZ cord-280642-cvxni7cd 295 4 a a DT cord-280642-cvxni7cd 295 5 policy policy NN cord-280642-cvxni7cd 295 6 of of IN cord-280642-cvxni7cd 295 7 recommending recommend VBG cord-280642-cvxni7cd 295 8 shielding shielding NN cord-280642-cvxni7cd 295 9 ( ( -LRB- cord-280642-cvxni7cd 295 10 i.e. i.e. FW cord-280642-cvxni7cd 295 11 minimising minimise VBG cord-280642-cvxni7cd 295 12 face face NN cord-280642-cvxni7cd 295 13 to to IN cord-280642-cvxni7cd 295 14 face face NN cord-280642-cvxni7cd 295 15 contact contact NN cord-280642-cvxni7cd 295 16 ) ) -RRB- cord-280642-cvxni7cd 295 17 for for IN cord-280642-cvxni7cd 295 18 groups group NNS cord-280642-cvxni7cd 295 19 identified identify VBN cord-280642-cvxni7cd 295 20 as as IN cord-280642-cvxni7cd 295 21 being be VBG cord-280642-cvxni7cd 295 22 extremely extremely RB cord-280642-cvxni7cd 295 23 vulnerable vulnerable JJ cord-280642-cvxni7cd 295 24 to to IN cord-280642-cvxni7cd 295 25 COVID-19 covid-19 VB cord-280642-cvxni7cd 295 26 on on IN cord-280642-cvxni7cd 295 27 the the DT cord-280642-cvxni7cd 295 28 basis basis NN cord-280642-cvxni7cd 295 29 of of IN cord-280642-cvxni7cd 295 30 pre pre JJ cord-280642-cvxni7cd 295 31 - - JJ cord-280642-cvxni7cd 295 32 existing existing JJ cord-280642-cvxni7cd 295 33 medical medical JJ cord-280642-cvxni7cd 295 34 conditions condition NNS cord-280642-cvxni7cd 295 35 . . . cord-280642-cvxni7cd 296 1 We -PRON- PRP cord-280642-cvxni7cd 296 2 were be VBD cord-280642-cvxni7cd 296 3 able able JJ cord-280642-cvxni7cd 296 4 to to TO cord-280642-cvxni7cd 296 5 evaluate evaluate VB cord-280642-cvxni7cd 296 6 the the DT cord-280642-cvxni7cd 296 7 association association NN cord-280642-cvxni7cd 296 8 between between IN cord-280642-cvxni7cd 296 9 most most JJS cord-280642-cvxni7cd 296 10 of of IN cord-280642-cvxni7cd 296 11 these these DT cord-280642-cvxni7cd 296 12 conditions condition NNS cord-280642-cvxni7cd 296 13 and and CC cord-280642-cvxni7cd 296 14 death death NN cord-280642-cvxni7cd 296 15 from from IN cord-280642-cvxni7cd 296 16 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 296 17 , , , cord-280642-cvxni7cd 296 18 and and CC cord-280642-cvxni7cd 296 19 confirm confirm VB cord-280642-cvxni7cd 296 20 that that IN cord-280642-cvxni7cd 296 21 people people NNS cord-280642-cvxni7cd 296 22 with with IN cord-280642-cvxni7cd 296 23 these these DT cord-280642-cvxni7cd 296 24 conditions condition NNS cord-280642-cvxni7cd 296 25 do do VBP cord-280642-cvxni7cd 296 26 have have VB cord-280642-cvxni7cd 296 27 substantially substantially RB cord-280642-cvxni7cd 296 28 increased increase VBN cord-280642-cvxni7cd 296 29 mortality mortality NN cord-280642-cvxni7cd 296 30 risk risk NN cord-280642-cvxni7cd 296 31 , , , cord-280642-cvxni7cd 296 32 supporting support VBG cord-280642-cvxni7cd 296 33 the the DT cord-280642-cvxni7cd 296 34 shielding shielding NN cord-280642-cvxni7cd 296 35 strategy strategy NN cord-280642-cvxni7cd 296 36 . . . cord-280642-cvxni7cd 297 1 We -PRON- PRP cord-280642-cvxni7cd 297 2 have have VBP cord-280642-cvxni7cd 297 3 demonstrated demonstrate VBN cord-280642-cvxni7cd 297 4 -for -for NFP cord-280642-cvxni7cd 297 5 the the DT cord-280642-cvxni7cd 297 6 first first JJ cord-280642-cvxni7cd 297 7 time time NN cord-280642-cvxni7cd 297 8 -that -that WP cord-280642-cvxni7cd 297 9 only only RB cord-280642-cvxni7cd 297 10 a a DT cord-280642-cvxni7cd 297 11 small small JJ cord-280642-cvxni7cd 297 12 part part NN cord-280642-cvxni7cd 297 13 of of IN cord-280642-cvxni7cd 297 14 the the DT cord-280642-cvxni7cd 297 15 substantially substantially RB cord-280642-cvxni7cd 297 16 increased increase VBN cord-280642-cvxni7cd 297 17 risks risk NNS cord-280642-cvxni7cd 297 18 of of IN cord-280642-cvxni7cd 297 19 death death NN cord-280642-cvxni7cd 297 20 from from IN cord-280642-cvxni7cd 297 21 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 297 22 among among IN cord-280642-cvxni7cd 297 23 nonwhite nonwhite JJ cord-280642-cvxni7cd 297 24 groups group NNS cord-280642-cvxni7cd 297 25 and and CC cord-280642-cvxni7cd 297 26 among among IN cord-280642-cvxni7cd 297 27 people people NNS cord-280642-cvxni7cd 297 28 living live VBG cord-280642-cvxni7cd 297 29 in in IN cord-280642-cvxni7cd 297 30 more more RBR cord-280642-cvxni7cd 297 31 deprived deprived JJ cord-280642-cvxni7cd 297 32 areas area NNS cord-280642-cvxni7cd 297 33 can can MD cord-280642-cvxni7cd 297 34 be be VB cord-280642-cvxni7cd 297 35 attributed attribute VBN cord-280642-cvxni7cd 297 36 to to IN cord-280642-cvxni7cd 297 37 existing exist VBG cord-280642-cvxni7cd 297 38 disease disease NN cord-280642-cvxni7cd 297 39 . . . cord-280642-cvxni7cd 298 1 Improved improved JJ cord-280642-cvxni7cd 298 2 strategies strategy NNS cord-280642-cvxni7cd 298 3 to to TO cord-280642-cvxni7cd 298 4 protect protect VB cord-280642-cvxni7cd 298 5 people people NNS cord-280642-cvxni7cd 298 6 in in IN cord-280642-cvxni7cd 298 7 these these DT cord-280642-cvxni7cd 298 8 groups group NNS cord-280642-cvxni7cd 298 9 from from IN cord-280642-cvxni7cd 298 10 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 298 11 need need VBP cord-280642-cvxni7cd 298 12 urgent urgent JJ cord-280642-cvxni7cd 298 13 consideration consideration NN cord-280642-cvxni7cd 298 14 . . . cord-280642-cvxni7cd 299 1 The the DT cord-280642-cvxni7cd 299 2 UK UK NNP cord-280642-cvxni7cd 299 3 has have VBZ cord-280642-cvxni7cd 299 4 an an DT cord-280642-cvxni7cd 299 5 unusually unusually RB cord-280642-cvxni7cd 299 6 large large JJ cord-280642-cvxni7cd 299 7 volume volume NN cord-280642-cvxni7cd 299 8 of of IN cord-280642-cvxni7cd 299 9 very very RB cord-280642-cvxni7cd 299 10 detailed detailed JJ cord-280642-cvxni7cd 299 11 longitudinal longitudinal JJ cord-280642-cvxni7cd 299 12 patient patient NN cord-280642-cvxni7cd 299 13 data datum NNS cord-280642-cvxni7cd 299 14 , , , cord-280642-cvxni7cd 299 15 especially especially RB cord-280642-cvxni7cd 299 16 through through IN cord-280642-cvxni7cd 299 17 primary primary JJ cord-280642-cvxni7cd 299 18 care care NN cord-280642-cvxni7cd 299 19 . . . cord-280642-cvxni7cd 300 1 We -PRON- PRP cord-280642-cvxni7cd 300 2 believe believe VBP cord-280642-cvxni7cd 300 3 the the DT cord-280642-cvxni7cd 300 4 UK UK NNP cord-280642-cvxni7cd 300 5 has have VBZ cord-280642-cvxni7cd 300 6 a a DT cord-280642-cvxni7cd 300 7 responsibility responsibility NN cord-280642-cvxni7cd 300 8 to to IN cord-280642-cvxni7cd 300 9 the the DT cord-280642-cvxni7cd 300 10 global global JJ cord-280642-cvxni7cd 300 11 community community NN cord-280642-cvxni7cd 300 12 to to TO cord-280642-cvxni7cd 300 13 make make VB cord-280642-cvxni7cd 300 14 good good JJ cord-280642-cvxni7cd 300 15 use use NN cord-280642-cvxni7cd 300 16 of of IN cord-280642-cvxni7cd 300 17 this this DT cord-280642-cvxni7cd 300 18 data data NN cord-280642-cvxni7cd 300 19 , , , cord-280642-cvxni7cd 300 20 securely securely RB cord-280642-cvxni7cd 300 21 , , , cord-280642-cvxni7cd 300 22 and and CC cord-280642-cvxni7cd 300 23 to to IN cord-280642-cvxni7cd 300 24 the the DT cord-280642-cvxni7cd 300 25 highest high JJS cord-280642-cvxni7cd 300 26 scientific scientific JJ cord-280642-cvxni7cd 300 27 standards standard NNS cord-280642-cvxni7cd 300 28 . . . cord-280642-cvxni7cd 301 1 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 301 2 demonstrates demonstrate VBZ cord-280642-cvxni7cd 301 3 the the DT cord-280642-cvxni7cd 301 4 value value NN cord-280642-cvxni7cd 301 5 of of IN cord-280642-cvxni7cd 301 6 this this DT cord-280642-cvxni7cd 301 7 data data NN cord-280642-cvxni7cd 301 8 in in IN cord-280642-cvxni7cd 301 9 practice practice NN cord-280642-cvxni7cd 301 10 . . . cord-280642-cvxni7cd 302 1 We -PRON- PRP cord-280642-cvxni7cd 302 2 will will MD cord-280642-cvxni7cd 302 3 enhance enhance VB cord-280642-cvxni7cd 302 4 the the DT cord-280642-cvxni7cd 302 5 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 302 6 platform platform NN cord-280642-cvxni7cd 302 7 to to TO cord-280642-cvxni7cd 302 8 further further RB cord-280642-cvxni7cd 302 9 inform inform VB cord-280642-cvxni7cd 302 10 the the DT cord-280642-cvxni7cd 302 11 global global JJ cord-280642-cvxni7cd 302 12 response response NN cord-280642-cvxni7cd 302 13 to to IN cord-280642-cvxni7cd 302 14 the the DT cord-280642-cvxni7cd 302 15 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 302 16 emergency emergency NN cord-280642-cvxni7cd 302 17 . . . cord-280642-cvxni7cd 303 1 The the DT cord-280642-cvxni7cd 303 2 underlying underlie VBG cord-280642-cvxni7cd 303 3 causes cause NNS cord-280642-cvxni7cd 303 4 of of IN cord-280642-cvxni7cd 303 5 higher high JJR cord-280642-cvxni7cd 303 6 risk risk NN cord-280642-cvxni7cd 303 7 among among IN cord-280642-cvxni7cd 303 8 those those DT cord-280642-cvxni7cd 303 9 from from IN cord-280642-cvxni7cd 303 10 non non JJ cord-280642-cvxni7cd 303 11 - - JJ cord-280642-cvxni7cd 303 12 white white JJ cord-280642-cvxni7cd 303 13 backgrounds background NNS cord-280642-cvxni7cd 303 14 , , , cord-280642-cvxni7cd 303 15 and and CC cord-280642-cvxni7cd 303 16 deprived deprive VBN cord-280642-cvxni7cd 303 17 areas area NNS cord-280642-cvxni7cd 303 18 , , , cord-280642-cvxni7cd 303 19 require require VBP cord-280642-cvxni7cd 303 20 further further JJ cord-280642-cvxni7cd 303 21 exploration exploration NN cord-280642-cvxni7cd 303 22 ; ; : cord-280642-cvxni7cd 303 23 we -PRON- PRP cord-280642-cvxni7cd 303 24 would would MD cord-280642-cvxni7cd 303 25 suggest suggest VB cord-280642-cvxni7cd 303 26 collecting collect VBG cord-280642-cvxni7cd 303 27 data datum NNS cord-280642-cvxni7cd 303 28 on on IN cord-280642-cvxni7cd 303 29 occupational occupational JJ cord-280642-cvxni7cd 303 30 exposure exposure NN cord-280642-cvxni7cd 303 31 and and CC cord-280642-cvxni7cd 303 32 living living NN cord-280642-cvxni7cd 303 33 conditions condition NNS cord-280642-cvxni7cd 303 34 as as IN cord-280642-cvxni7cd 303 35 first first JJ cord-280642-cvxni7cd 303 36 steps step NNS cord-280642-cvxni7cd 303 37 . . . cord-280642-cvxni7cd 304 1 The the DT cord-280642-cvxni7cd 304 2 statistical statistical JJ cord-280642-cvxni7cd 304 3 power power NN cord-280642-cvxni7cd 304 4 offered offer VBN cord-280642-cvxni7cd 304 5 by by IN cord-280642-cvxni7cd 304 6 our -PRON- PRP$ cord-280642-cvxni7cd 304 7 approach approach NN cord-280642-cvxni7cd 304 8 means mean VBZ cord-280642-cvxni7cd 304 9 that that IN cord-280642-cvxni7cd 304 10 associations association NNS cord-280642-cvxni7cd 304 11 with with IN cord-280642-cvxni7cd 304 12 less less RBR cord-280642-cvxni7cd 304 13 common common JJ cord-280642-cvxni7cd 304 14 risk risk NN cord-280642-cvxni7cd 304 15 factors factor NNS cord-280642-cvxni7cd 304 16 can can MD cord-280642-cvxni7cd 304 17 be be VB cord-280642-cvxni7cd 304 18 robustly robustly RB cord-280642-cvxni7cd 304 19 assessed assess VBN cord-280642-cvxni7cd 304 20 in in IN cord-280642-cvxni7cd 304 21 more more JJR cord-280642-cvxni7cd 304 22 detail detail NN cord-280642-cvxni7cd 304 23 , , , cord-280642-cvxni7cd 304 24 at at IN cord-280642-cvxni7cd 304 25 the the DT cord-280642-cvxni7cd 304 26 earliest early JJS cord-280642-cvxni7cd 304 27 possible possible JJ cord-280642-cvxni7cd 304 28 date date NN cord-280642-cvxni7cd 304 29 , , , cord-280642-cvxni7cd 304 30 as as IN cord-280642-cvxni7cd 304 31 the the DT cord-280642-cvxni7cd 304 32 pandemic pandemic NN cord-280642-cvxni7cd 304 33 progresses progress VBZ cord-280642-cvxni7cd 304 34 . . . cord-280642-cvxni7cd 305 1 We -PRON- PRP cord-280642-cvxni7cd 305 2 will will MD cord-280642-cvxni7cd 305 3 therefore therefore RB cord-280642-cvxni7cd 305 4 update update VB cord-280642-cvxni7cd 305 5 our -PRON- PRP$ cord-280642-cvxni7cd 305 6 findings finding NNS cord-280642-cvxni7cd 305 7 and and CC cord-280642-cvxni7cd 305 8 address address VB cord-280642-cvxni7cd 305 9 smaller small JJR cord-280642-cvxni7cd 305 10 risk risk NN cord-280642-cvxni7cd 305 11 groups group NNS cord-280642-cvxni7cd 305 12 as as IN cord-280642-cvxni7cd 305 13 new new JJ cord-280642-cvxni7cd 305 14 cases case NNS cord-280642-cvxni7cd 305 15 arise arise VBP cord-280642-cvxni7cd 305 16 over over IN cord-280642-cvxni7cd 305 17 time time NN cord-280642-cvxni7cd 305 18 . . . cord-280642-cvxni7cd 306 1 The the DT cord-280642-cvxni7cd 306 2 open open JJ cord-280642-cvxni7cd 306 3 source source NN cord-280642-cvxni7cd 306 4 re re IN cord-280642-cvxni7cd 306 5 - - JJ cord-280642-cvxni7cd 306 6 usable usable JJ cord-280642-cvxni7cd 306 7 codebase codebase RB cord-280642-cvxni7cd 306 8 on on IN cord-280642-cvxni7cd 306 9 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 306 10 supports support VBZ cord-280642-cvxni7cd 306 11 rapid rapid JJ cord-280642-cvxni7cd 306 12 , , , cord-280642-cvxni7cd 306 13 secure secure JJ cord-280642-cvxni7cd 306 14 and and CC cord-280642-cvxni7cd 306 15 collaborative collaborative JJ cord-280642-cvxni7cd 306 16 development development NN cord-280642-cvxni7cd 306 17 of of IN cord-280642-cvxni7cd 306 18 new new JJ cord-280642-cvxni7cd 306 19 analyses analysis NNS cord-280642-cvxni7cd 306 20 : : : cord-280642-cvxni7cd 306 21 we -PRON- PRP cord-280642-cvxni7cd 306 22 are be VBP cord-280642-cvxni7cd 306 23 currently currently RB cord-280642-cvxni7cd 306 24 conducting conduct VBG cord-280642-cvxni7cd 306 25 expedited expedite VBN cord-280642-cvxni7cd 306 26 studies study NNS cord-280642-cvxni7cd 306 27 on on IN cord-280642-cvxni7cd 306 28 the the DT cord-280642-cvxni7cd 306 29 impact impact NN cord-280642-cvxni7cd 306 30 of of IN cord-280642-cvxni7cd 306 31 various various JJ cord-280642-cvxni7cd 306 32 medical medical JJ cord-280642-cvxni7cd 306 33 treatments treatment NNS cord-280642-cvxni7cd 306 34 and and CC cord-280642-cvxni7cd 306 35 population population NN cord-280642-cvxni7cd 306 36 interventions intervention NNS cord-280642-cvxni7cd 306 37 on on IN cord-280642-cvxni7cd 306 38 the the DT cord-280642-cvxni7cd 306 39 risk risk NN cord-280642-cvxni7cd 306 40 of of IN cord-280642-cvxni7cd 306 41 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 306 42 infection infection NN cord-280642-cvxni7cd 306 43 , , , cord-280642-cvxni7cd 306 44 ITU ITU NNP cord-280642-cvxni7cd 306 45 admission admission NN cord-280642-cvxni7cd 306 46 , , , cord-280642-cvxni7cd 306 47 and and CC cord-280642-cvxni7cd 306 48 death death NN cord-280642-cvxni7cd 306 49 , , , cord-280642-cvxni7cd 306 50 alongside alongside IN cord-280642-cvxni7cd 306 51 other other JJ cord-280642-cvxni7cd 306 52 observational observational JJ cord-280642-cvxni7cd 306 53 analyses analysis NNS cord-280642-cvxni7cd 306 54 . . . cord-280642-cvxni7cd 307 1 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 307 2 is be VBZ cord-280642-cvxni7cd 307 3 rapidly rapidly RB cord-280642-cvxni7cd 307 4 scalable scalable JJ cord-280642-cvxni7cd 307 5 for for IN cord-280642-cvxni7cd 307 6 additional additional JJ cord-280642-cvxni7cd 307 7 NHS NHS NNP cord-280642-cvxni7cd 307 8 patients patient NNS cord-280642-cvxni7cd 307 9 ' ' POS cord-280642-cvxni7cd 307 10 records record NNS cord-280642-cvxni7cd 307 11 , , , cord-280642-cvxni7cd 307 12 with with IN cord-280642-cvxni7cd 307 13 new new JJ cord-280642-cvxni7cd 307 14 data datum NNS cord-280642-cvxni7cd 307 15 sources source NNS cord-280642-cvxni7cd 307 16 progressing progress VBG cord-280642-cvxni7cd 307 17 . . . cord-280642-cvxni7cd 308 1 We -PRON- PRP cord-280642-cvxni7cd 308 2 report report VBP cord-280642-cvxni7cd 308 3 early early JJ cord-280642-cvxni7cd 308 4 data datum NNS cord-280642-cvxni7cd 308 5 on on IN cord-280642-cvxni7cd 308 6 risk risk NN cord-280642-cvxni7cd 308 7 factors factor NNS cord-280642-cvxni7cd 308 8 for for IN cord-280642-cvxni7cd 308 9 death death NN cord-280642-cvxni7cd 308 10 from from IN cord-280642-cvxni7cd 308 11 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 308 12 using use VBG cord-280642-cvxni7cd 308 13 an an DT cord-280642-cvxni7cd 308 14 unprecedented unprecedented JJ cord-280642-cvxni7cd 308 15 scale scale NN cord-280642-cvxni7cd 308 16 of of IN cord-280642-cvxni7cd 308 17 17 17 CD cord-280642-cvxni7cd 308 18 million million CD cord-280642-cvxni7cd 308 19 patients patient NNS cord-280642-cvxni7cd 308 20 ' ' POS cord-280642-cvxni7cd 308 21 detailed detailed JJ cord-280642-cvxni7cd 308 22 primary primary JJ cord-280642-cvxni7cd 308 23 care care NN cord-280642-cvxni7cd 308 24 records record NNS cord-280642-cvxni7cd 308 25 in in IN cord-280642-cvxni7cd 308 26 the the DT cord-280642-cvxni7cd 308 27 context context NN cord-280642-cvxni7cd 308 28 of of IN cord-280642-cvxni7cd 308 29 a a DT cord-280642-cvxni7cd 308 30 global global JJ cord-280642-cvxni7cd 308 31 health health NN cord-280642-cvxni7cd 308 32 emergency emergency NN cord-280642-cvxni7cd 308 33 ; ; : cord-280642-cvxni7cd 308 34 we -PRON- PRP cord-280642-cvxni7cd 308 35 will will MD cord-280642-cvxni7cd 308 36 update update VB cord-280642-cvxni7cd 308 37 our -PRON- PRP$ cord-280642-cvxni7cd 308 38 findings finding NNS cord-280642-cvxni7cd 308 39 as as IN cord-280642-cvxni7cd 308 40 new new JJ cord-280642-cvxni7cd 308 41 data data NN cord-280642-cvxni7cd 308 42 arises arise VBZ cord-280642-cvxni7cd 308 43 . . . cord-280642-cvxni7cd 308 44 _SP cord-280642-cvxni7cd 308 45 . . . cord-280642-cvxni7cd 309 1 CC CC NNP cord-280642-cvxni7cd 309 2 - - : cord-280642-cvxni7cd 309 3 BY by IN cord-280642-cvxni7cd 309 4 4.0 4.0 CD cord-280642-cvxni7cd 309 5 International international JJ cord-280642-cvxni7cd 309 6 license license NN cord-280642-cvxni7cd 310 1 It -PRON- PRP cord-280642-cvxni7cd 310 2 is be VBZ cord-280642-cvxni7cd 310 3 made make VBN cord-280642-cvxni7cd 310 4 available available JJ cord-280642-cvxni7cd 310 5 under under IN cord-280642-cvxni7cd 310 6 a a DT cord-280642-cvxni7cd 311 1 is be VBZ cord-280642-cvxni7cd 311 2 the the DT cord-280642-cvxni7cd 311 3 author author NN cord-280642-cvxni7cd 311 4 / / SYM cord-280642-cvxni7cd 311 5 funder funder NN cord-280642-cvxni7cd 311 6 , , , cord-280642-cvxni7cd 311 7 who who WP cord-280642-cvxni7cd 311 8 has have VBZ cord-280642-cvxni7cd 311 9 granted grant VBN cord-280642-cvxni7cd 311 10 medRxiv medRxiv NNS cord-280642-cvxni7cd 311 11 a a DT cord-280642-cvxni7cd 311 12 license license NN cord-280642-cvxni7cd 311 13 to to TO cord-280642-cvxni7cd 311 14 display display VB cord-280642-cvxni7cd 311 15 the the DT cord-280642-cvxni7cd 311 16 preprint preprint NN cord-280642-cvxni7cd 311 17 in in IN cord-280642-cvxni7cd 311 18 perpetuity perpetuity NN cord-280642-cvxni7cd 311 19 . . . cord-280642-cvxni7cd 312 1 ( ( -LRB- cord-280642-cvxni7cd 312 2 which which WDT cord-280642-cvxni7cd 312 3 was be VBD cord-280642-cvxni7cd 312 4 not not RB cord-280642-cvxni7cd 312 5 certified certify VBN cord-280642-cvxni7cd 312 6 by by IN cord-280642-cvxni7cd 312 7 peer peer NN cord-280642-cvxni7cd 312 8 review review NN cord-280642-cvxni7cd 312 9 ) ) -RRB- cord-280642-cvxni7cd 313 1 The the DT cord-280642-cvxni7cd 313 2 copyright copyright NN cord-280642-cvxni7cd 313 3 holder holder NN cord-280642-cvxni7cd 313 4 for for IN cord-280642-cvxni7cd 313 5 this this DT cord-280642-cvxni7cd 313 6 preprint preprint NN cord-280642-cvxni7cd 313 7 this this DT cord-280642-cvxni7cd 313 8 version version NN cord-280642-cvxni7cd 313 9 posted post VBN cord-280642-cvxni7cd 313 10 May May NNP cord-280642-cvxni7cd 313 11 7 7 CD cord-280642-cvxni7cd 313 12 , , , cord-280642-cvxni7cd 313 13 2020 2020 CD cord-280642-cvxni7cd 313 14 . . . cord-280642-cvxni7cd 313 15 . . . cord-280642-cvxni7cd 314 1 https://doi.org/10.1101/2020.05.06.20092999 https://doi.org/10.1101/2020.05.06.20092999 NNP cord-280642-cvxni7cd 314 2 doi doi NNP cord-280642-cvxni7cd 314 3 : : : cord-280642-cvxni7cd 315 1 medRxiv medRxiv NNP cord-280642-cvxni7cd 315 2 preprint preprint NN cord-280642-cvxni7cd 315 3 WHO who WP cord-280642-cvxni7cd 315 4 . . . cord-280642-cvxni7cd 316 1 WHO who WP cord-280642-cvxni7cd 316 2 Director Director NNP cord-280642-cvxni7cd 316 3 - - HYPH cord-280642-cvxni7cd 316 4 General General NNP cord-280642-cvxni7cd 316 5 's 's POS cord-280642-cvxni7cd 316 6 opening opening NN cord-280642-cvxni7cd 316 7 remarks remark NNS cord-280642-cvxni7cd 316 8 at at IN cord-280642-cvxni7cd 316 9 the the DT cord-280642-cvxni7cd 316 10 media medium NNS cord-280642-cvxni7cd 316 11 briefing briefing NN cord-280642-cvxni7cd 316 12 on on IN cord-280642-cvxni7cd 316 13 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 316 14 -11 -11 IN cord-280642-cvxni7cd 316 15 WHO who WP cord-280642-cvxni7cd 316 16 . . . cord-280642-cvxni7cd 317 1 Coronavirus Coronavirus NNP cord-280642-cvxni7cd 317 2 disease disease NN cord-280642-cvxni7cd 317 3 2019 2019 CD cord-280642-cvxni7cd 318 1 ( ( -LRB- cord-280642-cvxni7cd 318 2 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 318 3 ) ) -RRB- cord-280642-cvxni7cd 318 4 Situation Situation NNP cord-280642-cvxni7cd 318 5 Report Report NNP cord-280642-cvxni7cd 318 6 -101 -101 NN cord-280642-cvxni7cd 319 1 Number number NN cord-280642-cvxni7cd 319 2 of of IN cord-280642-cvxni7cd 319 3 coronavirus coronavirus NN cord-280642-cvxni7cd 319 4 ( ( -LRB- cord-280642-cvxni7cd 319 5 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 319 6 ) ) -RRB- cord-280642-cvxni7cd 319 7 cases case NNS cord-280642-cvxni7cd 319 8 and and CC cord-280642-cvxni7cd 319 9 risk risk NN cord-280642-cvxni7cd 319 10 in in IN cord-280642-cvxni7cd 319 11 the the DT cord-280642-cvxni7cd 319 12 UK UK NNP cord-280642-cvxni7cd 320 1 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 320 2 Daily Daily NNP cord-280642-cvxni7cd 320 3 Deaths Deaths NNP cord-280642-cvxni7cd 320 4 Clinical clinical JJ cord-280642-cvxni7cd 320 5 determinants determinant NNS cord-280642-cvxni7cd 320 6 for for IN cord-280642-cvxni7cd 320 7 fatality fatality NN cord-280642-cvxni7cd 320 8 of of IN cord-280642-cvxni7cd 320 9 44,672 44,672 CD cord-280642-cvxni7cd 320 10 patients patient NNS cord-280642-cvxni7cd 320 11 with with IN cord-280642-cvxni7cd 320 12 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 320 13 Features Features NNPS cord-280642-cvxni7cd 320 14 of of IN cord-280642-cvxni7cd 320 15 16,749 16,749 CD cord-280642-cvxni7cd 320 16 hospitalised hospitalise VBN cord-280642-cvxni7cd 320 17 UK UK NNP cord-280642-cvxni7cd 320 18 patients patient NNS cord-280642-cvxni7cd 320 19 with with IN cord-280642-cvxni7cd 320 20 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 320 21 using use VBG cord-280642-cvxni7cd 320 22 the the DT cord-280642-cvxni7cd 320 23 ISARIC ISARIC NNP cord-280642-cvxni7cd 320 24 WHO who WP cord-280642-cvxni7cd 320 25 High high JJ cord-280642-cvxni7cd 320 26 prevalence prevalence NN cord-280642-cvxni7cd 320 27 of of IN cord-280642-cvxni7cd 320 28 obesity obesity NN cord-280642-cvxni7cd 320 29 in in IN cord-280642-cvxni7cd 320 30 severe severe JJ cord-280642-cvxni7cd 320 31 acute acute JJ cord-280642-cvxni7cd 320 32 respiratory respiratory JJ cord-280642-cvxni7cd 320 33 syndrome syndrome NN cord-280642-cvxni7cd 320 34 coronavirus-2 coronavirus-2 NN cord-280642-cvxni7cd 321 1 ( ( -LRB- cord-280642-cvxni7cd 321 2 SARS SARS NNP cord-280642-cvxni7cd 321 3 - - HYPH cord-280642-cvxni7cd 321 4 CoV-2 CoV-2 NNP cord-280642-cvxni7cd 321 5 ) ) -RRB- cord-280642-cvxni7cd 322 1 requiring require VBG cord-280642-cvxni7cd 322 2 invasive invasive JJ cord-280642-cvxni7cd 322 3 mechanical mechanical JJ cord-280642-cvxni7cd 322 4 ventilation ventilation NN cord-280642-cvxni7cd 322 5 Obesity obesity NN cord-280642-cvxni7cd 322 6 in in IN cord-280642-cvxni7cd 322 7 patients patient NNS cord-280642-cvxni7cd 323 1 younger young JJR cord-280642-cvxni7cd 323 2 than than IN cord-280642-cvxni7cd 323 3 60 60 CD cord-280642-cvxni7cd 323 4 years year NNS cord-280642-cvxni7cd 323 5 is be VBZ cord-280642-cvxni7cd 323 6 a a DT cord-280642-cvxni7cd 323 7 risk risk NN cord-280642-cvxni7cd 323 8 factor factor NN cord-280642-cvxni7cd 323 9 for for IN cord-280642-cvxni7cd 323 10 Covid-19 Covid-19 NNP cord-280642-cvxni7cd 323 11 hospital hospital NN cord-280642-cvxni7cd 323 12 admission admission NN cord-280642-cvxni7cd 324 1 The the DT cord-280642-cvxni7cd 324 2 association association NN cord-280642-cvxni7cd 324 3 of of IN cord-280642-cvxni7cd 324 4 smoking smoking NN cord-280642-cvxni7cd 324 5 status status NN cord-280642-cvxni7cd 324 6 with with IN cord-280642-cvxni7cd 324 7 SARS SARS NNP cord-280642-cvxni7cd 324 8 - - HYPH cord-280642-cvxni7cd 324 9 CoV-2 CoV-2 NNP cord-280642-cvxni7cd 324 10 infection infection NN cord-280642-cvxni7cd 324 11 , , , cord-280642-cvxni7cd 324 12 hospitalisation hospitalisation NN cord-280642-cvxni7cd 324 13 and and CC cord-280642-cvxni7cd 324 14 mortality mortality NN cord-280642-cvxni7cd 324 15 from from IN cord-280642-cvxni7cd 324 16 COVID-19 covid-19 NN cord-280642-cvxni7cd 324 17 : : : cord-280642-cvxni7cd 324 18 A a DT cord-280642-cvxni7cd 324 19 living live VBG cord-280642-cvxni7cd 324 20 rapid rapid JJ cord-280642-cvxni7cd 324 21 evidence evidence NN cord-280642-cvxni7cd 324 22 review review NN cord-280642-cvxni7cd 324 23 Clinical clinical JJ cord-280642-cvxni7cd 324 24 Characteristics Characteristics NNPS cord-280642-cvxni7cd 324 25 of of IN cord-280642-cvxni7cd 324 26 Coronavirus Coronavirus NNP cord-280642-cvxni7cd 324 27 Disease Disease NNP cord-280642-cvxni7cd 324 28 2019 2019 CD cord-280642-cvxni7cd 324 29 in in IN cord-280642-cvxni7cd 324 30 China China NNP cord-280642-cvxni7cd 324 31 Low low JJ cord-280642-cvxni7cd 324 32 incidence incidence NN cord-280642-cvxni7cd 324 33 of of IN cord-280642-cvxni7cd 324 34 daily daily JJ cord-280642-cvxni7cd 324 35 active active JJ cord-280642-cvxni7cd 324 36 tobacco tobacco NN cord-280642-cvxni7cd 324 37 smoking smoking NN cord-280642-cvxni7cd 324 38 in in IN cord-280642-cvxni7cd 324 39 patients patient NNS cord-280642-cvxni7cd 324 40 with with IN cord-280642-cvxni7cd 324 41 symptomatic symptomatic JJ cord-280642-cvxni7cd 324 42 COVID-19 covid-19 CD cord-280642-cvxni7cd 325 1 Is be VBZ cord-280642-cvxni7cd 325 2 ethnicity ethnicity NN cord-280642-cvxni7cd 325 3 linked link VBN cord-280642-cvxni7cd 325 4 to to IN cord-280642-cvxni7cd 325 5 incidence incidence NN cord-280642-cvxni7cd 325 6 or or CC cord-280642-cvxni7cd 325 7 outcomes outcome NNS cord-280642-cvxni7cd 325 8 of of IN cord-280642-cvxni7cd 325 9 covid-19 covid-19 NN cord-280642-cvxni7cd 325 10 ? ? . cord-280642-cvxni7cd 326 1 Are be VBP cord-280642-cvxni7cd 326 2 some some DT cord-280642-cvxni7cd 326 3 ethnic ethnic JJ cord-280642-cvxni7cd 326 4 groups group NNS cord-280642-cvxni7cd 326 5 more more RBR cord-280642-cvxni7cd 326 6 vulnerable vulnerable JJ cord-280642-cvxni7cd 326 7 to to IN cord-280642-cvxni7cd 326 8 COVID-19 covid-19 VB cord-280642-cvxni7cd 326 9 than than IN cord-280642-cvxni7cd 326 10 others other NNS cord-280642-cvxni7cd 326 11 ? ? . cord-280642-cvxni7cd 327 1 COVID-19 covid-19 LS cord-280642-cvxni7cd 327 2 ) ) -RRB- cord-280642-cvxni7cd 327 3 cases case NNS cord-280642-cvxni7cd 327 4 in in IN cord-280642-cvxni7cd 327 5 the the DT cord-280642-cvxni7cd 327 6 UK UK NNP cord-280642-cvxni7cd 327 7 Supporting support VBG cord-280642-cvxni7cd 327 8 providers provider NNS cord-280642-cvxni7cd 327 9 to to TO cord-280642-cvxni7cd 327 10 record record VB cord-280642-cvxni7cd 327 11 covid-19 covid-19 JJ cord-280642-cvxni7cd 327 12 patient patient NN cord-280642-cvxni7cd 327 13 notifications notification NNS cord-280642-cvxni7cd 327 14 Technical Technical NNP cord-280642-cvxni7cd 327 15 Summary Summary NNP cord-280642-cvxni7cd 327 16 : : : cord-280642-cvxni7cd 328 1 Public Public NNP cord-280642-cvxni7cd 328 2 Health Health NNP cord-280642-cvxni7cd 328 3 England England NNP cord-280642-cvxni7cd 328 4 Data Data NNP cord-280642-cvxni7cd 328 5 Series Series NNP cord-280642-cvxni7cd 328 6 on on IN cord-280642-cvxni7cd 328 7 Deaths death NNS cord-280642-cvxni7cd 328 8 in in IN cord-280642-cvxni7cd 328 9 People People NNS cord-280642-cvxni7cd 328 10 with with IN cord-280642-cvxni7cd 328 11 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 328 12 Development Development NNP cord-280642-cvxni7cd 328 13 and and CC cord-280642-cvxni7cd 328 14 validation validation NN cord-280642-cvxni7cd 328 15 of of IN cord-280642-cvxni7cd 328 16 an an DT cord-280642-cvxni7cd 328 17 electronic electronic JJ cord-280642-cvxni7cd 328 18 frailty frailty NN cord-280642-cvxni7cd 328 19 index index NN cord-280642-cvxni7cd 328 20 using use VBG cord-280642-cvxni7cd 328 21 routine routine JJ cord-280642-cvxni7cd 328 22 primary primary JJ cord-280642-cvxni7cd 328 23 care care NN cord-280642-cvxni7cd 328 24 electronic electronic JJ cord-280642-cvxni7cd 328 25 health health NN cord-280642-cvxni7cd 328 26 record record NN cord-280642-cvxni7cd 328 27 data datum NNS cord-280642-cvxni7cd 328 28 Estimating Estimating NNP cord-280642-cvxni7cd 328 29 primary primary JJ cord-280642-cvxni7cd 328 30 care care NN cord-280642-cvxni7cd 328 31 attendance attendance NN cord-280642-cvxni7cd 328 32 rates rate NNS cord-280642-cvxni7cd 328 33 for for IN cord-280642-cvxni7cd 328 34 fever fever NN cord-280642-cvxni7cd 328 35 in in IN cord-280642-cvxni7cd 328 36 infants infant NNS cord-280642-cvxni7cd 328 37 after after IN cord-280642-cvxni7cd 328 38 meningococcal meningococcal JJ cord-280642-cvxni7cd 328 39 B b NN cord-280642-cvxni7cd 328 40 vaccination vaccination NN cord-280642-cvxni7cd 328 41 in in IN cord-280642-cvxni7cd 328 42 England England NNP cord-280642-cvxni7cd 328 43 using use VBG cord-280642-cvxni7cd 328 44 national national JJ cord-280642-cvxni7cd 328 45 syndromic syndromic NNP cord-280642-cvxni7cd 328 46 surveillance surveillance NN cord-280642-cvxni7cd 328 47 data datum NNS cord-280642-cvxni7cd 329 1 The the DT cord-280642-cvxni7cd 329 2 relationship relationship NN cord-280642-cvxni7cd 329 3 between between IN cord-280642-cvxni7cd 329 4 time time NN cord-280642-cvxni7cd 329 5 since since IN cord-280642-cvxni7cd 329 6 registration registration NN cord-280642-cvxni7cd 329 7 and and CC cord-280642-cvxni7cd 329 8 measured measure VBN cord-280642-cvxni7cd 329 9 incidence incidence NN cord-280642-cvxni7cd 329 10 rates rate NNS cord-280642-cvxni7cd 329 11 in in IN cord-280642-cvxni7cd 329 12 the the DT cord-280642-cvxni7cd 329 13 General General NNP cord-280642-cvxni7cd 329 14 Practice Practice NNP cord-280642-cvxni7cd 329 15 Research Research NNP cord-280642-cvxni7cd 329 16 Database Database NNP cord-280642-cvxni7cd 329 17 Guidance Guidance NNP cord-280642-cvxni7cd 329 18 on on IN cord-280642-cvxni7cd 329 19 social social JJ cord-280642-cvxni7cd 329 20 distancing distancing NN cord-280642-cvxni7cd 329 21 for for IN cord-280642-cvxni7cd 329 22 everyone everyone NN cord-280642-cvxni7cd 329 23 in in IN cord-280642-cvxni7cd 329 24 the the DT cord-280642-cvxni7cd 329 25 UK UK NNP cord-280642-cvxni7cd 329 26 . . . cord-280642-cvxni7cd 330 1 GOV GOV NNP cord-280642-cvxni7cd 330 2 UK UK NNP cord-280642-cvxni7cd 330 3 immunisation immunisation NN cord-280642-cvxni7cd 330 4 schedule schedule NN cord-280642-cvxni7cd 330 5 : : : cord-280642-cvxni7cd 330 6 the the DT cord-280642-cvxni7cd 330 7 green green JJ cord-280642-cvxni7cd 330 8 book book NN cord-280642-cvxni7cd 330 9 , , , cord-280642-cvxni7cd 330 10 chapter chapter NN cord-280642-cvxni7cd 330 11 11 11 CD cord-280642-cvxni7cd 331 1 A a DT cord-280642-cvxni7cd 331 2 New new JJ cord-280642-cvxni7cd 331 3 Equation equation NN cord-280642-cvxni7cd 331 4 to to TO cord-280642-cvxni7cd 331 5 Estimate estimate VB cord-280642-cvxni7cd 331 6 Glomerular Glomerular NNP cord-280642-cvxni7cd 331 7 Filtration filtration NN cord-280642-cvxni7cd 331 8 Rate rate NN cord-280642-cvxni7cd 332 1 What what WP cord-280642-cvxni7cd 332 2 is be VBZ cord-280642-cvxni7cd 332 3 the the DT cord-280642-cvxni7cd 332 4 dm+d dm+d NN cord-280642-cvxni7cd 332 5 ? ? . cord-280642-cvxni7cd 333 1 The the DT cord-280642-cvxni7cd 333 2 NHS NHS NNP cord-280642-cvxni7cd 333 3 Dictionary Dictionary NNP cord-280642-cvxni7cd 333 4 of of IN cord-280642-cvxni7cd 333 5 Medicines Medicines NNPS cord-280642-cvxni7cd 333 6 and and CC cord-280642-cvxni7cd 333 7 Devices Devices NNPS cord-280642-cvxni7cd 333 8 Validation Validation NNP cord-280642-cvxni7cd 333 9 of of IN cord-280642-cvxni7cd 333 10 asthma asthma NN cord-280642-cvxni7cd 333 11 recording record VBG cord-280642-cvxni7cd 333 12 in in IN cord-280642-cvxni7cd 333 13 the the DT cord-280642-cvxni7cd 333 14 Clinical Clinical NNP cord-280642-cvxni7cd 333 15 Practice Practice NNP cord-280642-cvxni7cd 333 16 Research Research NNP cord-280642-cvxni7cd 333 17 Datalink Datalink NNP cord-280642-cvxni7cd 333 18 ( ( -LRB- cord-280642-cvxni7cd 333 19 CPRD CPRD NNP cord-280642-cvxni7cd 333 20 ) ) -RRB- cord-280642-cvxni7cd 333 21 Safety safety NN cord-280642-cvxni7cd 333 22 of of IN cord-280642-cvxni7cd 333 23 inadvertent inadvertent JJ cord-280642-cvxni7cd 333 24 administration administration NN cord-280642-cvxni7cd 333 25 of of IN cord-280642-cvxni7cd 333 26 live live JJ cord-280642-cvxni7cd 333 27 zoster zoster NNP cord-280642-cvxni7cd 333 28 vaccine vaccine NN cord-280642-cvxni7cd 333 29 to to IN cord-280642-cvxni7cd 333 30 immunosuppressed immunosuppressed JJ cord-280642-cvxni7cd 333 31 individuals individual NNS cord-280642-cvxni7cd 333 32 in in IN cord-280642-cvxni7cd 333 33 a a DT cord-280642-cvxni7cd 333 34 UK UK NNP cord-280642-cvxni7cd 333 35 - - HYPH cord-280642-cvxni7cd 333 36 based base VBN cord-280642-cvxni7cd 333 37 observational observational JJ cord-280642-cvxni7cd 333 38 cohort cohort NN cord-280642-cvxni7cd 333 39 analysis analysis NN cord-280642-cvxni7cd 333 40 Rheumatoid Rheumatoid NNP cord-280642-cvxni7cd 333 41 Arthritis Arthritis NNP cord-280642-cvxni7cd 333 42 and and CC cord-280642-cvxni7cd 333 43 Incidence Incidence NNP cord-280642-cvxni7cd 333 44 of of IN cord-280642-cvxni7cd 333 45 Twelve Twelve NNP cord-280642-cvxni7cd 333 46 Initial Initial NNP cord-280642-cvxni7cd 333 47 Presentations Presentations NNPS cord-280642-cvxni7cd 333 48 of of IN cord-280642-cvxni7cd 333 49 Cardiovascular Cardiovascular NNP cord-280642-cvxni7cd 333 50 Disease Disease NNP cord-280642-cvxni7cd 333 51 : : : cord-280642-cvxni7cd 334 1 A a DT cord-280642-cvxni7cd 334 2 Population Population NNP cord-280642-cvxni7cd 334 3 Record Record NNP cord-280642-cvxni7cd 334 4 - - HYPH cord-280642-cvxni7cd 334 5 Linkage Linkage NNP cord-280642-cvxni7cd 334 6 Cohort Cohort NNP cord-280642-cvxni7cd 334 7 Study Study NNP cord-280642-cvxni7cd 334 8 in in IN cord-280642-cvxni7cd 334 9 England England NNP cord-280642-cvxni7cd 334 10 Medium Medium NNP cord-280642-cvxni7cd 334 11 and and CC cord-280642-cvxni7cd 334 12 long long JJ cord-280642-cvxni7cd 334 13 - - HYPH cord-280642-cvxni7cd 334 14 term term NN cord-280642-cvxni7cd 334 15 risks risk NNS cord-280642-cvxni7cd 334 16 of of IN cord-280642-cvxni7cd 334 17 specific specific JJ cord-280642-cvxni7cd 334 18 cardiovascular cardiovascular JJ cord-280642-cvxni7cd 334 19 diseases disease NNS cord-280642-cvxni7cd 334 20 in in IN cord-280642-cvxni7cd 334 21 survivors survivor NNS cord-280642-cvxni7cd 334 22 of of IN cord-280642-cvxni7cd 334 23 20 20 CD cord-280642-cvxni7cd 334 24 adult adult NN cord-280642-cvxni7cd 334 25 cancers cancer NNS cord-280642-cvxni7cd 334 26 : : : cord-280642-cvxni7cd 334 27 a a DT cord-280642-cvxni7cd 334 28 populationbased populationbased JJ cord-280642-cvxni7cd 334 29 cohort cohort NN cord-280642-cvxni7cd 334 30 study study NN cord-280642-cvxni7cd 334 31 using use VBG cord-280642-cvxni7cd 334 32 multiple multiple JJ cord-280642-cvxni7cd 334 33 linked link VBN cord-280642-cvxni7cd 334 34 UK UK NNP cord-280642-cvxni7cd 334 35 electronic electronic JJ cord-280642-cvxni7cd 334 36 health health NN cord-280642-cvxni7cd 334 37 records record NNS cord-280642-cvxni7cd 334 38 databases database NNS cord-280642-cvxni7cd 334 39 OpenSAFELY OpenSAFELY NNP cord-280642-cvxni7cd 334 40 Codelists codelist NNS cord-280642-cvxni7cd 334 41 : : : cord-280642-cvxni7cd 334 42 Cancer cancer NN cord-280642-cvxni7cd 334 43 excluding exclude VBG cord-280642-cvxni7cd 334 44 lung lung NN cord-280642-cvxni7cd 334 45 and and CC cord-280642-cvxni7cd 334 46 haematological haematological NNP cord-280642-cvxni7cd 334 47 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 334 48 in in IN cord-280642-cvxni7cd 334 49 Great Great NNP cord-280642-cvxni7cd 334 50 Britain Britain NNP cord-280642-cvxni7cd 334 51 : : : cord-280642-cvxni7cd 334 52 epidemiological epidemiological JJ cord-280642-cvxni7cd 334 53 and and CC cord-280642-cvxni7cd 334 54 clinical clinical JJ cord-280642-cvxni7cd 334 55 characteristics characteristic NNS cord-280642-cvxni7cd 334 56 of of IN cord-280642-cvxni7cd 334 57 the the DT cord-280642-cvxni7cd 334 58 first first JJ cord-280642-cvxni7cd 334 59 few few JJ cord-280642-cvxni7cd 334 60 hundred hundred CD cord-280642-cvxni7cd 334 61 ( ( -LRB- cord-280642-cvxni7cd 334 62 FF100 FF100 NNP cord-280642-cvxni7cd 334 63 ) ) -RRB- cord-280642-cvxni7cd 334 64 cases case NNS cord-280642-cvxni7cd 334 65 : : : cord-280642-cvxni7cd 334 66 a a DT cord-280642-cvxni7cd 334 67 descriptive descriptive JJ cord-280642-cvxni7cd 334 68 study study NN cord-280642-cvxni7cd 335 1 ISB1523 isb1523 RB cord-280642-cvxni7cd 335 2 : : : cord-280642-cvxni7cd 336 1 Anonymisation Anonymisation NNP cord-280642-cvxni7cd 336 2 Standard Standard NNP cord-280642-cvxni7cd 336 3 for for IN cord-280642-cvxni7cd 336 4 Publishing Publishing NNP cord-280642-cvxni7cd 336 5 Health Health NNP cord-280642-cvxni7cd 336 6 and and CC cord-280642-cvxni7cd 336 7 Social Social NNP cord-280642-cvxni7cd 336 8 Care Care NNP cord-280642-cvxni7cd 336 9 Data Data NNP cord-280642-cvxni7cd 336 10 -NHS -NHS JJR cord-280642-cvxni7cd 336 11 Digital Digital NNP cord-280642-cvxni7cd 336 12 Secretary Secretary NNP cord-280642-cvxni7cd 336 13 of of IN cord-280642-cvxni7cd 336 14 State State NNP cord-280642-cvxni7cd 336 15 for for IN cord-280642-cvxni7cd 336 16 Health Health NNP cord-280642-cvxni7cd 336 17 and and CC cord-280642-cvxni7cd 336 18 Social Social NNP cord-280642-cvxni7cd 336 19 Care Care NNP cord-280642-cvxni7cd 336 20 -UK -UK HYPH cord-280642-cvxni7cd 336 21 Government Government NNP cord-280642-cvxni7cd 336 22 . . . cord-280642-cvxni7cd 337 1 Coronavirus Coronavirus NNP cord-280642-cvxni7cd 337 2 ( ( -LRB- cord-280642-cvxni7cd 337 3 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 337 4 ) ) -RRB- cord-280642-cvxni7cd 337 5 : : : cord-280642-cvxni7cd 337 6 notification notification NN cord-280642-cvxni7cd 337 7 to to IN cord-280642-cvxni7cd 337 8 organisations organisation NNS cord-280642-cvxni7cd 337 9 to to TO cord-280642-cvxni7cd 337 10 share share VB cord-280642-cvxni7cd 337 11 information information NN cord-280642-cvxni7cd 337 12 Impact Impact NNP cord-280642-cvxni7cd 337 13 Of of IN cord-280642-cvxni7cd 337 14 Electronic Electronic NNP cord-280642-cvxni7cd 337 15 Health Health NNP cord-280642-cvxni7cd 337 16 Record Record NNP cord-280642-cvxni7cd 337 17 Interface Interface NNP cord-280642-cvxni7cd 337 18 Design Design NNP cord-280642-cvxni7cd 337 19 On on IN cord-280642-cvxni7cd 337 20 Unsafe unsafe JJ cord-280642-cvxni7cd 337 21 Prescribing prescribing NN cord-280642-cvxni7cd 337 22 Of of IN cord-280642-cvxni7cd 337 23 Ciclosporin Ciclosporin NNP cord-280642-cvxni7cd 337 24 , , , cord-280642-cvxni7cd 337 25 Tacrolimus Tacrolimus NNP cord-280642-cvxni7cd 337 26 and and CC cord-280642-cvxni7cd 337 27 Diltiazem Diltiazem NNP cord-280642-cvxni7cd 337 28 : : : cord-280642-cvxni7cd 337 29 A a DT cord-280642-cvxni7cd 337 30 Cohort Cohort NNP cord-280642-cvxni7cd 337 31 Study Study NNP cord-280642-cvxni7cd 337 32 In in IN cord-280642-cvxni7cd 337 33 English English NNP cord-280642-cvxni7cd 337 34 NHS NHS NNP cord-280642-cvxni7cd 337 35 Primary Primary NNP cord-280642-cvxni7cd 337 36 Care Care NNP cord-280642-cvxni7cd 337 37 . . . cord-280642-cvxni7cd 338 1 JMIR JMIR NNP cord-280642-cvxni7cd 338 2 Preprints Preprints NNP cord-280642-cvxni7cd 338 3 : : : cord-280642-cvxni7cd 338 4 Accepted accept VBN cord-280642-cvxni7cd 338 5 for for IN cord-280642-cvxni7cd 338 6 publication publication NN cord-280642-cvxni7cd 338 7 Quality quality NN cord-280642-cvxni7cd 338 8 of of IN cord-280642-cvxni7cd 338 9 Co Co NNP cord-280642-cvxni7cd 338 10 - - JJ cord-280642-cvxni7cd 338 11 Prescribing Prescribing NNP cord-280642-cvxni7cd 338 12 NSAID NSAID NNP cord-280642-cvxni7cd 338 13 and and CC cord-280642-cvxni7cd 338 14 Gastroprotective Gastroprotective NNP cord-280642-cvxni7cd 338 15 Medications Medications NNPS cord-280642-cvxni7cd 338 16 for for IN cord-280642-cvxni7cd 338 17 Elders elder NNS cord-280642-cvxni7cd 338 18 in in IN cord-280642-cvxni7cd 338 19 The the DT cord-280642-cvxni7cd 338 20 Netherlands Netherlands NNP cord-280642-cvxni7cd 338 21 and and CC cord-280642-cvxni7cd 338 22 Its -PRON- PRP$ cord-280642-cvxni7cd 338 23 Association Association NNP cord-280642-cvxni7cd 338 24 with with IN cord-280642-cvxni7cd 338 25 the the DT cord-280642-cvxni7cd 338 26 Electronic Electronic NNP cord-280642-cvxni7cd 338 27 Medical Medical NNP cord-280642-cvxni7cd 338 28 Record Record NNP cord-280642-cvxni7cd 338 29 Ghost Ghost NNP cord-280642-cvxni7cd 338 30 branded brand VBN cord-280642-cvxni7cd 338 31 generics generic NNS cord-280642-cvxni7cd 338 32 : : : cord-280642-cvxni7cd 338 33 Why why WRB cord-280642-cvxni7cd 338 34 does do VBZ cord-280642-cvxni7cd 338 35 the the DT cord-280642-cvxni7cd 338 36 cost cost NN cord-280642-cvxni7cd 338 37 of of IN cord-280642-cvxni7cd 338 38 generic generic JJ cord-280642-cvxni7cd 338 39 atorvastatin atorvastatin NN cord-280642-cvxni7cd 338 40 vary vary VBP cord-280642-cvxni7cd 338 41 ? ? . cord-280642-cvxni7cd 339 1 EBM EBM NNP cord-280642-cvxni7cd 339 2 DataLab DataLab NNP cord-280642-cvxni7cd 339 3 Completeness Completeness NNP cord-280642-cvxni7cd 339 4 and and CC cord-280642-cvxni7cd 339 5 usability usability NN cord-280642-cvxni7cd 339 6 of of IN cord-280642-cvxni7cd 339 7 ethnicity ethnicity NN cord-280642-cvxni7cd 339 8 data datum NNS cord-280642-cvxni7cd 339 9 in in IN cord-280642-cvxni7cd 339 10 UK UK NNP cord-280642-cvxni7cd 339 11 - - HYPH cord-280642-cvxni7cd 339 12 based base VBN cord-280642-cvxni7cd 339 13 primary primary JJ cord-280642-cvxni7cd 339 14 care care NN cord-280642-cvxni7cd 339 15 and and CC cord-280642-cvxni7cd 339 16 hospital hospital NN cord-280642-cvxni7cd 339 17 databases database NNS cord-280642-cvxni7cd 339 18 ONS ons NN cord-280642-cvxni7cd 339 19 . . . cord-280642-cvxni7cd 340 1 Deaths death NNS cord-280642-cvxni7cd 340 2 registered register VBD cord-280642-cvxni7cd 340 3 weekly weekly NN cord-280642-cvxni7cd 340 4 in in IN cord-280642-cvxni7cd 340 5 England England NNP cord-280642-cvxni7cd 340 6 and and CC cord-280642-cvxni7cd 340 7 Wales Wales NNP cord-280642-cvxni7cd 340 8 , , , cord-280642-cvxni7cd 340 9 provisional provisional JJ cord-280642-cvxni7cd 340 10 : : : cord-280642-cvxni7cd 340 11 week week NN cord-280642-cvxni7cd 340 12 ending end VBG cord-280642-cvxni7cd 340 13 17 17 CD cord-280642-cvxni7cd 340 14 Do do VB cord-280642-cvxni7cd 340 15 chronic chronic JJ cord-280642-cvxni7cd 340 16 respiratory respiratory JJ cord-280642-cvxni7cd 340 17 diseases disease NNS cord-280642-cvxni7cd 340 18 or or CC cord-280642-cvxni7cd 340 19 their -PRON- PRP$ cord-280642-cvxni7cd 340 20 treatment treatment NN cord-280642-cvxni7cd 340 21 affect affect VBP cord-280642-cvxni7cd 340 22 the the DT cord-280642-cvxni7cd 340 23 risk risk NN cord-280642-cvxni7cd 340 24 of of IN cord-280642-cvxni7cd 340 25 SARS SARS NNP cord-280642-cvxni7cd 340 26 - - HYPH cord-280642-cvxni7cd 340 27 CoV-2 CoV-2 NNP cord-280642-cvxni7cd 340 28 infection infection NN cord-280642-cvxni7cd 340 29 ? ? . cord-280642-cvxni7cd 341 1 Smoking smoking NN cord-280642-cvxni7cd 341 2 , , , cord-280642-cvxni7cd 341 3 vaping vaping NN cord-280642-cvxni7cd 341 4 and and CC cord-280642-cvxni7cd 341 5 hospitalization hospitalization NN cord-280642-cvxni7cd 341 6 for for IN cord-280642-cvxni7cd 341 7 COVID-19 COVID-19 NNP cord-280642-cvxni7cd 341 8 Covid-19 Covid-19 NNP cord-280642-cvxni7cd 341 9 Testing Testing NNP cord-280642-cvxni7cd 341 10 , , , cord-280642-cvxni7cd 341 11 Hospital Hospital NNP cord-280642-cvxni7cd 341 12 Admission Admission NNP cord-280642-cvxni7cd 341 13 , , , cord-280642-cvxni7cd 341 14 and and CC cord-280642-cvxni7cd 341 15 Intensive Intensive NNP cord-280642-cvxni7cd 341 16 Care Care NNP cord-280642-cvxni7cd 341 17 Among among IN cord-280642-cvxni7cd 341 18 2,026,227 2,026,227 CD cord-280642-cvxni7cd 341 19 United United NNP cord-280642-cvxni7cd 341 20 States States NNP cord-280642-cvxni7cd 341 21 Veterans Veterans NNPS cord-280642-cvxni7cd 341 22 Aged aged JJ cord-280642-cvxni7cd 341 23 FOOTNOTES footnote NNS cord-280642-cvxni7cd 341 24 : : : cord-280642-cvxni7cd 341 25 Models model NNS cord-280642-cvxni7cd 341 26 adjusted adjust VBN cord-280642-cvxni7cd 341 27 for for IN cord-280642-cvxni7cd 341 28 age age NN cord-280642-cvxni7cd 341 29 using use VBG cord-280642-cvxni7cd 341 30 a a DT cord-280642-cvxni7cd 341 31 4-knot 4-knot CD cord-280642-cvxni7cd 341 32 cubic cubic JJ cord-280642-cvxni7cd 341 33 spline spline NN cord-280642-cvxni7cd 341 34 age age NN cord-280642-cvxni7cd 341 35 spline spline NN cord-280642-cvxni7cd 341 36 , , , cord-280642-cvxni7cd 341 37 except except IN cord-280642-cvxni7cd 341 38 for for IN cord-280642-cvxni7cd 341 39 estimation estimation NN cord-280642-cvxni7cd 341 40 of of IN cord-280642-cvxni7cd 341 41 age age NN cord-280642-cvxni7cd 341 42 group group NN cord-280642-cvxni7cd 341 43 effects effect NNS cord-280642-cvxni7cd 341 44 . . . cord-280642-cvxni7cd 342 1 * * NFP cord-280642-cvxni7cd 342 2 Ethnicity ethnicity NN cord-280642-cvxni7cd 342 3 effect effect NN cord-280642-cvxni7cd 342 4 estimated estimate VBN cord-280642-cvxni7cd 342 5 from from IN cord-280642-cvxni7cd 342 6 a a DT cord-280642-cvxni7cd 342 7 model model NN cord-280642-cvxni7cd 342 8 restricted restrict VBN cord-280642-cvxni7cd 342 9 to to IN cord-280642-cvxni7cd 342 10 those those DT cord-280642-cvxni7cd 342 11 with with IN cord-280642-cvxni7cd 342 12 recorded recorded JJ cord-280642-cvxni7cd 342 13 ethnicity ethnicity NN cord-280642-cvxni7cd 342 14 . . . cord-280642-cvxni7cd 343 1 * * NFP cord-280642-cvxni7cd 343 2 2 2 CD cord-280642-cvxni7cd 343 3 OCS OCS NNP cord-280642-cvxni7cd 343 4 = = SYM cord-280642-cvxni7cd 343 5 oral oral JJ cord-280642-cvxni7cd 343 6 corticosteroids corticosteroid NNS cord-280642-cvxni7cd 344 1 We -PRON- PRP cord-280642-cvxni7cd 344 2 are be VBP cord-280642-cvxni7cd 344 3 very very RB cord-280642-cvxni7cd 344 4 grateful grateful JJ cord-280642-cvxni7cd 344 5 for for IN cord-280642-cvxni7cd 344 6 all all PDT cord-280642-cvxni7cd 344 7 the the DT cord-280642-cvxni7cd 344 8 support support NN cord-280642-cvxni7cd 344 9 received receive VBN cord-280642-cvxni7cd 344 10 from from IN cord-280642-cvxni7cd 344 11 the the DT cord-280642-cvxni7cd 344 12 TPP TPP NNP cord-280642-cvxni7cd 344 13 Technical Technical NNP cord-280642-cvxni7cd 344 14 Operations Operations NNPS cord-280642-cvxni7cd 344 15 team team NN cord-280642-cvxni7cd 344 16 throughout throughout IN cord-280642-cvxni7cd 344 17 this this DT cord-280642-cvxni7cd 344 18 work work NN cord-280642-cvxni7cd 344 19 ; ; : cord-280642-cvxni7cd 344 20 for for IN cord-280642-cvxni7cd 344 21 generous generous JJ cord-280642-cvxni7cd 344 22 assistance assistance NN cord-280642-cvxni7cd 344 23 from from IN cord-280642-cvxni7cd 344 24 the the DT cord-280642-cvxni7cd 344 25 information information NN cord-280642-cvxni7cd 344 26 governance governance NN cord-280642-cvxni7cd 344 27 and and CC cord-280642-cvxni7cd 344 28 database database NN cord-280642-cvxni7cd 344 29 teams team NNS cord-280642-cvxni7cd 344 30 at at IN cord-280642-cvxni7cd 344 31 NHS NHS NNP cord-280642-cvxni7cd 344 32 England England NNP cord-280642-cvxni7cd 344 33 / / SYM cord-280642-cvxni7cd 344 34 NHSX NHSX NNP cord-280642-cvxni7cd 344 35 ; ; : cord-280642-cvxni7cd 344 36 and and CC cord-280642-cvxni7cd 344 37 for for IN cord-280642-cvxni7cd 344 38 additional additional JJ cord-280642-cvxni7cd 344 39 discussions discussion NNS cord-280642-cvxni7cd 344 40 on on IN cord-280642-cvxni7cd 344 41 disease disease NN cord-280642-cvxni7cd 344 42 All all DT cord-280642-cvxni7cd 344 43 authors author NNS cord-280642-cvxni7cd 344 44 have have VBP cord-280642-cvxni7cd 344 45 completed complete VBN cord-280642-cvxni7cd 344 46 the the DT cord-280642-cvxni7cd 344 47 ICMJE ICMJE NNP cord-280642-cvxni7cd 344 48 uniform uniform JJ cord-280642-cvxni7cd 344 49 disclosure disclosure NN cord-280642-cvxni7cd 344 50 form form NN cord-280642-cvxni7cd 344 51 at at IN cord-280642-cvxni7cd 344 52 www.icmje.org/coi_disclosure.pdf www.icmje.org/coi_disclosure.pdf NNP cord-280642-cvxni7cd 344 53 and and CC cord-280642-cvxni7cd 344 54 declare declare VB cord-280642-cvxni7cd 344 55 the the DT cord-280642-cvxni7cd 344 56 following follow VBG cord-280642-cvxni7cd 344 57 : : : cord-280642-cvxni7cd 344 58 CB CB NNP cord-280642-cvxni7cd 344 59 JP JP NNP cord-280642-cvxni7cd 344 60 FH FH NNP cord-280642-cvxni7cd 344 61 JC JC NNP cord-280642-cvxni7cd 344 62 SH SH NNP cord-280642-cvxni7cd 344 63 are be VBP cord-280642-cvxni7cd 344 64 employees employee NNS cord-280642-cvxni7cd 344 65 of of IN cord-280642-cvxni7cd 344 66 TPP TPP NNP cord-280642-cvxni7cd 344 67 . . . cord-280642-cvxni7cd 345 1 No no DT cord-280642-cvxni7cd 345 2 dedicated dedicated JJ cord-280642-cvxni7cd 345 3 funding funding NN cord-280642-cvxni7cd 345 4 has have VBZ cord-280642-cvxni7cd 345 5 yet yet RB cord-280642-cvxni7cd 345 6 been be VBN cord-280642-cvxni7cd 345 7 obtained obtain VBN cord-280642-cvxni7cd 345 8 for for IN cord-280642-cvxni7cd 345 9 this this DT cord-280642-cvxni7cd 345 10 work work NN cord-280642-cvxni7cd 345 11 . . . cord-280642-cvxni7cd 346 1 TPP TPP NNP cord-280642-cvxni7cd 346 2 provided provide VBD cord-280642-cvxni7cd 346 3 technical technical JJ cord-280642-cvxni7cd 346 4 expertise expertise NN cord-280642-cvxni7cd 346 5 and and CC cord-280642-cvxni7cd 346 6 infrastructure infrastructure NN cord-280642-cvxni7cd 346 7 within within IN cord-280642-cvxni7cd 346 8 their -PRON- PRP$ cord-280642-cvxni7cd 346 9 data datum NNS cord-280642-cvxni7cd 346 10 centre centre NN cord-280642-cvxni7cd 346 11 pro pro FW cord-280642-cvxni7cd 346 12 bono bono FW cord-280642-cvxni7cd 346 13 in in IN cord-280642-cvxni7cd 346 14 the the DT cord-280642-cvxni7cd 346 15 context context NN cord-280642-cvxni7cd 346 16 of of IN cord-280642-cvxni7cd 346 17 a a DT cord-280642-cvxni7cd 346 18 national national JJ cord-280642-cvxni7cd 346 19 emergency emergency NN cord-280642-cvxni7cd 346 20 . . . cord-280642-cvxni7cd 347 1 BG BG NNP cord-280642-cvxni7cd 347 2 's 's POS cord-280642-cvxni7cd 347 3 work work NN cord-280642-cvxni7cd 347 4 on on IN cord-280642-cvxni7cd 347 5 better well JJR cord-280642-cvxni7cd 347 6 use use NN cord-280642-cvxni7cd 347 7 of of IN cord-280642-cvxni7cd 347 8 data datum NNS cord-280642-cvxni7cd 347 9 in in IN cord-280642-cvxni7cd 347 10 healthcare healthcare NN cord-280642-cvxni7cd 347 11 more more RBR cord-280642-cvxni7cd 347 12 broadly broadly RB cord-280642-cvxni7cd 347 13 is be VBZ cord-280642-cvxni7cd 347 14 currently currently RB cord-280642-cvxni7cd 347 15 funded fund VBN cord-280642-cvxni7cd 347 16 in in IN cord-280642-cvxni7cd 347 17 part part NN cord-280642-cvxni7cd 347 18 by by IN cord-280642-cvxni7cd 347 19 : : : cord-280642-cvxni7cd 347 20 Figure figure NN cord-280642-cvxni7cd 347 21 A1 A1 NNP cord-280642-cvxni7cd 347 22 . . . cord-280642-cvxni7cd 348 1 Estimated estimate VBN cord-280642-cvxni7cd 348 2 log log NN cord-280642-cvxni7cd 348 3 hazard hazard NN cord-280642-cvxni7cd 348 4 ratio ratio NN cord-280642-cvxni7cd 348 5 by by IN cord-280642-cvxni7cd 348 6 age age NN cord-280642-cvxni7cd 348 7 in in IN cord-280642-cvxni7cd 348 8 years year NNS cord-280642-cvxni7cd 349 1 From from IN cord-280642-cvxni7cd 349 2 the the DT cord-280642-cvxni7cd 349 3 primary primary JJ cord-280642-cvxni7cd 349 4 fully fully RB cord-280642-cvxni7cd 349 5 adjusted adjust VBN cord-280642-cvxni7cd 349 6 model model NN cord-280642-cvxni7cd 349 7 containing contain VBG cord-280642-cvxni7cd 349 8 a a DT cord-280642-cvxni7cd 349 9 4-knot 4-knot CD cord-280642-cvxni7cd 349 10 cubic cubic JJ cord-280642-cvxni7cd 349 11 spline spline NN cord-280642-cvxni7cd 349 12 for for IN cord-280642-cvxni7cd 349 13 age age NN cord-280642-cvxni7cd 349 14 , , , cord-280642-cvxni7cd 349 15 and and CC cord-280642-cvxni7cd 349 16 adjusted adjust VBN cord-280642-cvxni7cd 349 17 for for IN cord-280642-cvxni7cd 349 18 all all DT cord-280642-cvxni7cd 349 19 covariates covariate NNS cord-280642-cvxni7cd 349 20 listed list VBN cord-280642-cvxni7cd 349 21 in in IN cord-280642-cvxni7cd 349 22 Table Table NNP cord-280642-cvxni7cd 349 23 2 2 CD cord-280642-cvxni7cd 349 24 except except IN cord-280642-cvxni7cd 349 25 for for IN cord-280642-cvxni7cd 349 26 ethnicity ethnicity NN cord-280642-cvxni7cd 349 27 . . .