id sid tid token lemma pos cord-277774-kec1o4ys 1 1 key key JJ cord-277774-kec1o4ys 1 2 : : : cord-277774-kec1o4ys 1 3 cord-277774-kec1o4ys cord-277774-kec1o4ys CD cord-277774-kec1o4ys 1 4 authors author NNS cord-277774-kec1o4ys 1 5 : : : cord-277774-kec1o4ys 1 6 Wang Wang NNP cord-277774-kec1o4ys 1 7 , , , cord-277774-kec1o4ys 1 8 Shangqian Shangqian NNP cord-277774-kec1o4ys 1 9 ; ; : cord-277774-kec1o4ys 1 10 Zhou Zhou NNP cord-277774-kec1o4ys 1 11 , , , cord-277774-kec1o4ys 1 12 Xiang Xiang NNP cord-277774-kec1o4ys 1 13 ; ; : cord-277774-kec1o4ys 1 14 Zhang Zhang NNP cord-277774-kec1o4ys 1 15 , , , cord-277774-kec1o4ys 1 16 Tongtong Tongtong NNP cord-277774-kec1o4ys 1 17 ; ; : cord-277774-kec1o4ys 1 18 Wang Wang NNP cord-277774-kec1o4ys 1 19 , , , cord-277774-kec1o4ys 2 1 Zengjun Zengjun NNP cord-277774-kec1o4ys 2 2 title title NN cord-277774-kec1o4ys 2 3 : : : cord-277774-kec1o4ys 3 1 The the DT cord-277774-kec1o4ys 3 2 need need NN cord-277774-kec1o4ys 3 3 for for IN cord-277774-kec1o4ys 3 4 urogenital urogenital JJ cord-277774-kec1o4ys 3 5 tract tract NN cord-277774-kec1o4ys 3 6 monitoring monitoring NN cord-277774-kec1o4ys 3 7 in in IN cord-277774-kec1o4ys 3 8 COVID-19 COVID-19 NNP cord-277774-kec1o4ys 3 9 date date NN cord-277774-kec1o4ys 3 10 : : : cord-277774-kec1o4ys 3 11 2020 2020 CD cord-277774-kec1o4ys 3 12 - - HYPH cord-277774-kec1o4ys 3 13 04 04 CD cord-277774-kec1o4ys 3 14 - - SYM cord-277774-kec1o4ys 3 15 20 20 CD cord-277774-kec1o4ys 3 16 journal journal NN cord-277774-kec1o4ys 3 17 : : : cord-277774-kec1o4ys 4 1 Nat Nat NNP cord-277774-kec1o4ys 4 2 Rev Rev NNP cord-277774-kec1o4ys 4 3 Urol Urol NNP cord-277774-kec1o4ys 4 4 DOI DOI NNP cord-277774-kec1o4ys 4 5 : : : cord-277774-kec1o4ys 5 1 10.1038 10.1038 CD cord-277774-kec1o4ys 5 2 / / SYM cord-277774-kec1o4ys 5 3 s41585 s41585 NN cord-277774-kec1o4ys 5 4 - - HYPH cord-277774-kec1o4ys 5 5 020 020 CD cord-277774-kec1o4ys 5 6 - - HYPH cord-277774-kec1o4ys 5 7 0319 0319 CD cord-277774-kec1o4ys 5 8 - - SYM cord-277774-kec1o4ys 5 9 7 7 CD cord-277774-kec1o4ys 6 1 sha sha NNP cord-277774-kec1o4ys 6 2 : : : cord-277774-kec1o4ys 6 3 1c9e12485b789075cf7d7d09ecd9da8363782c2d 1c9e12485b789075cf7d7d09ecd9da8363782c2d CD cord-277774-kec1o4ys 7 1 doc_id doc_id CD cord-277774-kec1o4ys 7 2 : : : cord-277774-kec1o4ys 8 1 277774 277774 CD cord-277774-kec1o4ys 8 2 cord_uid cord_uid NNS cord-277774-kec1o4ys 8 3 : : : cord-277774-kec1o4ys 8 4 kec1o4ys kec1o4ys NNP cord-277774-kec1o4ys 8 5 Coronavirus Coronavirus NNP cord-277774-kec1o4ys 8 6 disease disease NN cord-277774-kec1o4ys 8 7 2019 2019 CD cord-277774-kec1o4ys 9 1 ( ( -LRB- cord-277774-kec1o4ys 9 2 COVID-19 COVID-19 NNP cord-277774-kec1o4ys 9 3 ) ) -RRB- cord-277774-kec1o4ys 9 4 is be VBZ cord-277774-kec1o4ys 9 5 caused cause VBN cord-277774-kec1o4ys 9 6 by by IN cord-277774-kec1o4ys 9 7 severe severe JJ cord-277774-kec1o4ys 9 8 acute acute JJ cord-277774-kec1o4ys 9 9 respiratory respiratory JJ cord-277774-kec1o4ys 9 10 syndrome syndrome NN cord-277774-kec1o4ys 9 11 coronavirus coronavirus NN cord-277774-kec1o4ys 9 12 2 2 CD cord-277774-kec1o4ys 9 13 , , , cord-277774-kec1o4ys 9 14 which which WDT cord-277774-kec1o4ys 9 15 invades invade VBZ cord-277774-kec1o4ys 9 16 a a DT cord-277774-kec1o4ys 9 17 cell cell NN cord-277774-kec1o4ys 9 18 through through IN cord-277774-kec1o4ys 9 19 binding bind VBG cord-277774-kec1o4ys 9 20 to to IN cord-277774-kec1o4ys 9 21 the the DT cord-277774-kec1o4ys 9 22 ACE2 ACE2 NNP cord-277774-kec1o4ys 9 23 receptor receptor NN cord-277774-kec1o4ys 9 24 and and CC cord-277774-kec1o4ys 9 25 TMPRSS2 tmprss2 NN cord-277774-kec1o4ys 9 26 priming priming NN cord-277774-kec1o4ys 9 27 . . . cord-277774-kec1o4ys 10 1 Patients patient NNS cord-277774-kec1o4ys 10 2 with with IN cord-277774-kec1o4ys 10 3 severe severe JJ cord-277774-kec1o4ys 10 4 disease disease NN cord-277774-kec1o4ys 10 5 predominantly predominantly RB cord-277774-kec1o4ys 10 6 present present JJ cord-277774-kec1o4ys 10 7 with with IN cord-277774-kec1o4ys 10 8 pneumonia pneumonia NN cord-277774-kec1o4ys 10 9 - - HYPH cord-277774-kec1o4ys 10 10 related relate VBN cord-277774-kec1o4ys 10 11 symptoms symptom NNS cord-277774-kec1o4ys 10 12 . . . cord-277774-kec1o4ys 11 1 However however RB cord-277774-kec1o4ys 11 2 , , , cord-277774-kec1o4ys 11 3 evidence evidence NN cord-277774-kec1o4ys 11 4 suggests suggest VBZ cord-277774-kec1o4ys 11 5 that that IN cord-277774-kec1o4ys 11 6 COVID-19 covid-19 DT cord-277774-kec1o4ys 11 7 infection infection NN cord-277774-kec1o4ys 11 8 also also RB cord-277774-kec1o4ys 11 9 has have VBZ cord-277774-kec1o4ys 11 10 implications implication NNS cord-277774-kec1o4ys 11 11 for for IN cord-277774-kec1o4ys 11 12 the the DT cord-277774-kec1o4ys 11 13 urogenital urogenital JJ cord-277774-kec1o4ys 11 14 tract tract NN cord-277774-kec1o4ys 11 15 . . . cord-277774-kec1o4ys 12 1 Thus thus RB cord-277774-kec1o4ys 12 2 , , , cord-277774-kec1o4ys 12 3 urogenital urogenital JJ cord-277774-kec1o4ys 12 4 organs organ NNS cord-277774-kec1o4ys 12 5 should should MD cord-277774-kec1o4ys 12 6 be be VB cord-277774-kec1o4ys 12 7 considered consider VBN cord-277774-kec1o4ys 12 8 when when WRB cord-277774-kec1o4ys 12 9 treating treat VBG cord-277774-kec1o4ys 12 10 COVID-19 covid-19 NN cord-277774-kec1o4ys 12 11 . . . cord-277774-kec1o4ys 13 1 In in IN cord-277774-kec1o4ys 13 2 December December NNP cord-277774-kec1o4ys 13 3 2019 2019 CD cord-277774-kec1o4ys 13 4 , , , cord-277774-kec1o4ys 13 5 a a DT cord-277774-kec1o4ys 13 6 series series NN cord-277774-kec1o4ys 13 7 of of IN cord-277774-kec1o4ys 13 8 patients patient NNS cord-277774-kec1o4ys 13 9 with with IN cord-277774-kec1o4ys 13 10 symptoms symptom NNS cord-277774-kec1o4ys 13 11 resembling resemble VBG cord-277774-kec1o4ys 13 12 viral viral JJ cord-277774-kec1o4ys 13 13 pneumonia pneumonia NN cord-277774-kec1o4ys 13 14 presented present VBN cord-277774-kec1o4ys 13 15 in in IN cord-277774-kec1o4ys 13 16 Wuhan Wuhan NNP cord-277774-kec1o4ys 13 17 , , , cord-277774-kec1o4ys 13 18 Hubei Hubei NNP cord-277774-kec1o4ys 13 19 province province NN cord-277774-kec1o4ys 13 20 , , , cord-277774-kec1o4ys 13 21 China China NNP cord-277774-kec1o4ys 13 22 ; ; : cord-277774-kec1o4ys 13 23 however however RB cord-277774-kec1o4ys 13 24 , , , cord-277774-kec1o4ys 13 25 the the DT cord-277774-kec1o4ys 13 26 cause cause NN cord-277774-kec1o4ys 13 27 of of IN cord-277774-kec1o4ys 13 28 this this DT cord-277774-kec1o4ys 13 29 disease disease NN cord-277774-kec1o4ys 13 30 was be VBD cord-277774-kec1o4ys 13 31 unknown unknown JJ cord-277774-kec1o4ys 13 32 and and CC cord-277774-kec1o4ys 13 33 it -PRON- PRP cord-277774-kec1o4ys 13 34 spread spread VBD cord-277774-kec1o4ys 13 35 rapidly rapidly RB cord-277774-kec1o4ys 13 36 throughout throughout IN cord-277774-kec1o4ys 13 37 China China NNP cord-277774-kec1o4ys 13 38 . . . cord-277774-kec1o4ys 14 1 It -PRON- PRP cord-277774-kec1o4ys 14 2 was be VBD cord-277774-kec1o4ys 14 3 eventually eventually RB cord-277774-kec1o4ys 14 4 identified identify VBN cord-277774-kec1o4ys 14 5 as as IN cord-277774-kec1o4ys 14 6 a a DT cord-277774-kec1o4ys 14 7 novel novel JJ cord-277774-kec1o4ys 14 8 coronavirus coronavirus NN cord-277774-kec1o4ys 14 9 on on IN cord-277774-kec1o4ys 14 10 8 8 CD cord-277774-kec1o4ys 14 11 January January NNP cord-277774-kec1o4ys 14 12 2020 2020 CD cord-277774-kec1o4ys 14 13 by by IN cord-277774-kec1o4ys 14 14 The the DT cord-277774-kec1o4ys 14 15 Chinese Chinese NNP cord-277774-kec1o4ys 14 16 Centers Centers NNPS cord-277774-kec1o4ys 14 17 for for IN cord-277774-kec1o4ys 14 18 Disease Disease NNP cord-277774-kec1o4ys 14 19 Control Control NNP cord-277774-kec1o4ys 14 20 and and CC cord-277774-kec1o4ys 14 21 Prevention Prevention NNP cord-277774-kec1o4ys 14 22 . . . cord-277774-kec1o4ys 15 1 This this DT cord-277774-kec1o4ys 15 2 novel novel JJ cord-277774-kec1o4ys 15 3 coronavirus coronavirus NN cord-277774-kec1o4ys 15 4 was be VBD cord-277774-kec1o4ys 15 5 named name VBN cord-277774-kec1o4ys 15 6 severe severe JJ cord-277774-kec1o4ys 15 7 acute acute JJ cord-277774-kec1o4ys 15 8 respiratory respiratory JJ cord-277774-kec1o4ys 15 9 syndrome syndrome NN cord-277774-kec1o4ys 15 10 coronavirus coronavirus NN cord-277774-kec1o4ys 15 11 2 2 CD cord-277774-kec1o4ys 16 1 ( ( -LRB- cord-277774-kec1o4ys 16 2 SARS SARS NNP cord-277774-kec1o4ys 16 3 - - HYPH cord-277774-kec1o4ys 16 4 CoV-2 CoV-2 NNP cord-277774-kec1o4ys 16 5 ) ) -RRB- cord-277774-kec1o4ys 16 6 and and CC cord-277774-kec1o4ys 17 1 the the DT cord-277774-kec1o4ys 17 2 resulting result VBG cord-277774-kec1o4ys 17 3 disease disease NN cord-277774-kec1o4ys 17 4 termed term VBD cord-277774-kec1o4ys 17 5 2019 2019 CD cord-277774-kec1o4ys 17 6 novel novel NN cord-277774-kec1o4ys 17 7 coronavirus coronavirus NN cord-277774-kec1o4ys 17 8 ( ( -LRB- cord-277774-kec1o4ys 17 9 2019-nCoV 2019-ncov CD cord-277774-kec1o4ys 17 10 ) ) -RRB- cord-277774-kec1o4ys 17 11 , , , cord-277774-kec1o4ys 17 12 which which WDT cord-277774-kec1o4ys 17 13 was be VBD cord-277774-kec1o4ys 17 14 changed change VBN cord-277774-kec1o4ys 17 15 to to IN cord-277774-kec1o4ys 17 16 coronavirus coronavirus NN cord-277774-kec1o4ys 17 17 disease disease NN cord-277774-kec1o4ys 17 18 2019 2019 CD cord-277774-kec1o4ys 17 19 ( ( -LRB- cord-277774-kec1o4ys 17 20 COVID-19 COVID-19 NNP cord-277774-kec1o4ys 17 21 ) ) -RRB- cord-277774-kec1o4ys 17 22 , , , cord-277774-kec1o4ys 17 23 according accord VBG cord-277774-kec1o4ys 17 24 to to IN cord-277774-kec1o4ys 17 25 the the DT cord-277774-kec1o4ys 17 26 WHO WHO NNP cord-277774-kec1o4ys 17 27 Coronavirus Coronavirus NNP cord-277774-kec1o4ys 17 28 disease disease NN cord-277774-kec1o4ys 17 29 ( ( -LRB- cord-277774-kec1o4ys 17 30 COVID-2019 COVID-2019 NNP cord-277774-kec1o4ys 17 31 ) ) -RRB- cord-277774-kec1o4ys 17 32 situation situation NN cord-277774-kec1o4ys 17 33 reports report VBZ cord-277774-kec1o4ys 17 34 . . . cord-277774-kec1o4ys 18 1 As as IN cord-277774-kec1o4ys 18 2 of of IN cord-277774-kec1o4ys 18 3 5 5 CD cord-277774-kec1o4ys 18 4 April April NNP cord-277774-kec1o4ys 18 5 2020 2020 CD cord-277774-kec1o4ys 18 6 , , , cord-277774-kec1o4ys 18 7 > > XX cord-277774-kec1o4ys 18 8 1.2 1.2 CD cord-277774-kec1o4ys 18 9 million million CD cord-277774-kec1o4ys 18 10 cases case NNS cord-277774-kec1o4ys 18 11 and and CC cord-277774-kec1o4ys 18 12 64,606 64,606 CD cord-277774-kec1o4ys 18 13 deaths death NNS cord-277774-kec1o4ys 18 14 have have VBP cord-277774-kec1o4ys 18 15 been be VBN cord-277774-kec1o4ys 18 16 reported report VBN cord-277774-kec1o4ys 18 17 globally globally RB cord-277774-kec1o4ys 18 18 . . . cord-277774-kec1o4ys 19 1 SARS SARS NNP cord-277774-kec1o4ys 19 2 - - HYPH cord-277774-kec1o4ys 19 3 CoV-2 CoV-2 NNP cord-277774-kec1o4ys 19 4 is be VBZ cord-277774-kec1o4ys 19 5 a a DT cord-277774-kec1o4ys 19 6 betacoronavirus betacoronavirus NN cord-277774-kec1o4ys 19 7 and and CC cord-277774-kec1o4ys 19 8 disease disease NN cord-277774-kec1o4ys 19 9 symptoms symptom NNS cord-277774-kec1o4ys 19 10 resemble resemble VBP cord-277774-kec1o4ys 19 11 SARS SARS NNP cord-277774-kec1o4ys 19 12 - - HYPH cord-277774-kec1o4ys 19 13 CoV CoV NNP cord-277774-kec1o4ys 19 14 and and CC cord-277774-kec1o4ys 19 15 Middle Middle NNP cord-277774-kec1o4ys 19 16 East East NNP cord-277774-kec1o4ys 19 17 respiratory respiratory JJ cord-277774-kec1o4ys 19 18 syndrome syndrome NN cord-277774-kec1o4ys 19 19 coronavirus coronavirus NN cord-277774-kec1o4ys 19 20 ( ( -LRB- cord-277774-kec1o4ys 19 21 MERS MERS NNP cord-277774-kec1o4ys 19 22 - - HYPH cord-277774-kec1o4ys 19 23 CoV CoV NNP cord-277774-kec1o4ys 19 24 ) ) -RRB- cord-277774-kec1o4ys 19 25 . . . cord-277774-kec1o4ys 20 1 Most Most JJS cord-277774-kec1o4ys 20 2 patients patient NNS cord-277774-kec1o4ys 20 3 with with IN cord-277774-kec1o4ys 20 4 severe severe JJ cord-277774-kec1o4ys 20 5 COVID-19 covid-19 JJ cord-277774-kec1o4ys 20 6 present present JJ cord-277774-kec1o4ys 20 7 with with IN cord-277774-kec1o4ys 20 8 pneumonia pneumonia NN cord-277774-kec1o4ys 20 9 - - HYPH cord-277774-kec1o4ys 20 10 related relate VBN cord-277774-kec1o4ys 20 11 symptoms symptom NNS cord-277774-kec1o4ys 20 12 , , , cord-277774-kec1o4ys 20 13 but but CC cord-277774-kec1o4ys 20 14 some some DT cord-277774-kec1o4ys 20 15 patients patient NNS cord-277774-kec1o4ys 20 16 with with IN cord-277774-kec1o4ys 20 17 severe severe JJ cord-277774-kec1o4ys 20 18 disease disease NN cord-277774-kec1o4ys 20 19 could could MD cord-277774-kec1o4ys 20 20 develop develop VB cord-277774-kec1o4ys 20 21 serious serious JJ cord-277774-kec1o4ys 20 22 urinary urinary JJ cord-277774-kec1o4ys 20 23 complications complication NNS cord-277774-kec1o4ys 20 24 including include VBG cord-277774-kec1o4ys 20 25 acute acute JJ cord-277774-kec1o4ys 20 26 kidney kidney NN cord-277774-kec1o4ys 20 27 injury injury NN cord-277774-kec1o4ys 20 28 ( ( -LRB- cord-277774-kec1o4ys 20 29 AKI AKI NNP cord-277774-kec1o4ys 20 30 ) ) -RRB- cord-277774-kec1o4ys 20 31 , , , cord-277774-kec1o4ys 20 32 which which WDT cord-277774-kec1o4ys 20 33 requires require VBZ cord-277774-kec1o4ys 20 34 continuous continuous JJ cord-277774-kec1o4ys 20 35 renal renal JJ cord-277774-kec1o4ys 20 36 replacement replacement NN cord-277774-kec1o4ys 20 37 therapy therapy NN cord-277774-kec1o4ys 20 38 ( ( -LRB- cord-277774-kec1o4ys 20 39 CRRT CRRT NNP cord-277774-kec1o4ys 20 40 ) ) -RRB- cord-277774-kec1o4ys 20 41 1 1 CD cord-277774-kec1o4ys 20 42 . . . cord-277774-kec1o4ys 21 1 Furthermore furthermore RB cord-277774-kec1o4ys 21 2 , , , cord-277774-kec1o4ys 21 3 male male JJ cord-277774-kec1o4ys 21 4 reproductive reproductive JJ cord-277774-kec1o4ys 21 5 systems system NNS cord-277774-kec1o4ys 21 6 are be VBP cord-277774-kec1o4ys 21 7 vulnerable vulnerable JJ cord-277774-kec1o4ys 21 8 to to IN cord-277774-kec1o4ys 21 9 infection infection NN cord-277774-kec1o4ys 21 10 ; ; , cord-277774-kec1o4ys 21 11 dramatic dramatic JJ cord-277774-kec1o4ys 21 12 changes change NNS cord-277774-kec1o4ys 21 13 in in IN cord-277774-kec1o4ys 21 14 sex sex NN cord-277774-kec1o4ys 21 15 hormones hormone NNS cord-277774-kec1o4ys 21 16 in in IN cord-277774-kec1o4ys 21 17 patients patient NNS cord-277774-kec1o4ys 21 18 with with IN cord-277774-kec1o4ys 21 19 COVID-19 COVID-19 NNP cord-277774-kec1o4ys 21 20 have have VBP cord-277774-kec1o4ys 21 21 been be VBN cord-277774-kec1o4ys 21 22 observed observe VBN cord-277774-kec1o4ys 21 23 , , , cord-277774-kec1o4ys 21 24 suggesting suggest VBG cord-277774-kec1o4ys 21 25 gonadal gonadal JJ cord-277774-kec1o4ys 21 26 function function NN cord-277774-kec1o4ys 21 27 impairment impairment NN cord-277774-kec1o4ys 21 28 2 2 CD cord-277774-kec1o4ys 21 29 . . . cord-277774-kec1o4ys 22 1 Thus thus RB cord-277774-kec1o4ys 22 2 , , , cord-277774-kec1o4ys 22 3 understanding understand VBG cord-277774-kec1o4ys 22 4 the the DT cord-277774-kec1o4ys 22 5 mechanisms mechanism NNS cord-277774-kec1o4ys 22 6 by by IN cord-277774-kec1o4ys 22 7 which which WDT cord-277774-kec1o4ys 22 8 SARS SARS NNP cord-277774-kec1o4ys 22 9 - - HYPH cord-277774-kec1o4ys 22 10 CoV-2 CoV-2 NNP cord-277774-kec1o4ys 22 11 impairs impair VBZ cord-277774-kec1o4ys 22 12 the the DT cord-277774-kec1o4ys 22 13 urogenital urogenital JJ cord-277774-kec1o4ys 22 14 system system NN cord-277774-kec1o4ys 22 15 and and CC cord-277774-kec1o4ys 22 16 learning learn VBG cord-277774-kec1o4ys 22 17 from from IN cord-277774-kec1o4ys 22 18 previous previous JJ cord-277774-kec1o4ys 22 19 experience experience NN cord-277774-kec1o4ys 22 20 of of IN cord-277774-kec1o4ys 22 21 managing manage VBG cord-277774-kec1o4ys 22 22 these these DT cord-277774-kec1o4ys 22 23 complications complication NNS cord-277774-kec1o4ys 22 24 are be VBP cord-277774-kec1o4ys 22 25 of of IN cord-277774-kec1o4ys 22 26 great great JJ cord-277774-kec1o4ys 22 27 importance importance NN cord-277774-kec1o4ys 22 28 for for IN cord-277774-kec1o4ys 22 29 proper proper JJ cord-277774-kec1o4ys 22 30 treatment treatment NN cord-277774-kec1o4ys 22 31 and and CC cord-277774-kec1o4ys 22 32 rehabilitation rehabilitation NN cord-277774-kec1o4ys 22 33 planning planning NN cord-277774-kec1o4ys 22 34 . . . cord-277774-kec1o4ys 23 1 Acute acute JJ cord-277774-kec1o4ys 23 2 kidney kidney NN cord-277774-kec1o4ys 23 3 injury injury NN cord-277774-kec1o4ys 24 1 A a DT cord-277774-kec1o4ys 24 2 retrospective retrospective JJ cord-277774-kec1o4ys 24 3 study study NN cord-277774-kec1o4ys 24 4 by by IN cord-277774-kec1o4ys 24 5 Li Li NNP cord-277774-kec1o4ys 24 6 et et NNP cord-277774-kec1o4ys 24 7 al al NNP cord-277774-kec1o4ys 24 8 . . . cord-277774-kec1o4ys 25 1 1 1 LS cord-277774-kec1o4ys 25 2 involving involve VBG cord-277774-kec1o4ys 25 3 patients patient NNS cord-277774-kec1o4ys 25 4 with with IN cord-277774-kec1o4ys 25 5 COVID-19 COVID-19 NNP cord-277774-kec1o4ys 25 6 provides provide VBZ cord-277774-kec1o4ys 25 7 some some DT cord-277774-kec1o4ys 25 8 insights insight NNS cord-277774-kec1o4ys 25 9 into into IN cord-277774-kec1o4ys 25 10 the the DT cord-277774-kec1o4ys 25 11 effect effect NN cord-277774-kec1o4ys 25 12 of of IN cord-277774-kec1o4ys 25 13 this this DT cord-277774-kec1o4ys 25 14 infection infection NN cord-277774-kec1o4ys 25 15 on on IN cord-277774-kec1o4ys 25 16 the the DT cord-277774-kec1o4ys 25 17 kidneys kidney NNS cord-277774-kec1o4ys 25 18 and and CC cord-277774-kec1o4ys 25 19 the the DT cord-277774-kec1o4ys 25 20 importance importance NN cord-277774-kec1o4ys 25 21 of of IN cord-277774-kec1o4ys 25 22 monitoring monitor VBG cord-277774-kec1o4ys 25 23 kidney kidney NN cord-277774-kec1o4ys 25 24 function function NN cord-277774-kec1o4ys 25 25 . . . cord-277774-kec1o4ys 26 1 Proteinuria Proteinuria NNP cord-277774-kec1o4ys 26 2 was be VBD cord-277774-kec1o4ys 26 3 observed observe VBN cord-277774-kec1o4ys 26 4 in in IN cord-277774-kec1o4ys 26 5 60 60 CD cord-277774-kec1o4ys 26 6 % % NN cord-277774-kec1o4ys 26 7 of of IN cord-277774-kec1o4ys 26 8 patients patient NNS cord-277774-kec1o4ys 26 9 on on IN cord-277774-kec1o4ys 26 10 the the DT cord-277774-kec1o4ys 26 11 first first JJ cord-277774-kec1o4ys 26 12 day day NN cord-277774-kec1o4ys 26 13 of of IN cord-277774-kec1o4ys 26 14 admission admission NN cord-277774-kec1o4ys 26 15 , , , cord-277774-kec1o4ys 26 16 suggesting suggest VBG cord-277774-kec1o4ys 26 17 that that IN cord-277774-kec1o4ys 26 18 they -PRON- PRP cord-277774-kec1o4ys 26 19 had have VBD cord-277774-kec1o4ys 26 20 renal renal JJ cord-277774-kec1o4ys 26 21 injury injury NN cord-277774-kec1o4ys 26 22 before before IN cord-277774-kec1o4ys 26 23 or or CC cord-277774-kec1o4ys 26 24 at at IN cord-277774-kec1o4ys 26 25 the the DT cord-277774-kec1o4ys 26 26 moment moment NN cord-277774-kec1o4ys 26 27 of of IN cord-277774-kec1o4ys 26 28 admission admission NN cord-277774-kec1o4ys 26 29 . . . cord-277774-kec1o4ys 27 1 Elevated elevated JJ cord-277774-kec1o4ys 27 2 levels level NNS cord-277774-kec1o4ys 27 3 of of IN cord-277774-kec1o4ys 27 4 serum serum NN cord-277774-kec1o4ys 27 5 creatinine creatinine NN cord-277774-kec1o4ys 27 6 ( ( -LRB- cord-277774-kec1o4ys 27 7 SCr scr NN cord-277774-kec1o4ys 27 8 ) ) -RRB- cord-277774-kec1o4ys 27 9 ( ( -LRB- cord-277774-kec1o4ys 27 10 > > NFP cord-277774-kec1o4ys 27 11 104 104 CD cord-277774-kec1o4ys 27 12 μmol μmol NNP cord-277774-kec1o4ys 27 13 / / SYM cord-277774-kec1o4ys 27 14 l l NN cord-277774-kec1o4ys 27 15 for for IN cord-277774-kec1o4ys 27 16 men man NNS cord-277774-kec1o4ys 27 17 and and CC cord-277774-kec1o4ys 27 18 > > XX cord-277774-kec1o4ys 28 1 84 84 CD cord-277774-kec1o4ys 28 2 μmol μmol NNP cord-277774-kec1o4ys 28 3 / / SYM cord-277774-kec1o4ys 28 4 l l NN cord-277774-kec1o4ys 28 5 for for IN cord-277774-kec1o4ys 28 6 women woman NNS cord-277774-kec1o4ys 28 7 ) ) -RRB- cord-277774-kec1o4ys 28 8 and and CC cord-277774-kec1o4ys 28 9 blood blood NN cord-277774-kec1o4ys 28 10 urea urea NN cord-277774-kec1o4ys 28 11 nitrogen nitrogen NN cord-277774-kec1o4ys 28 12 ( ( -LRB- cord-277774-kec1o4ys 28 13 > > NFP cord-277774-kec1o4ys 28 14 8 8 CD cord-277774-kec1o4ys 28 15 mmol mmol NNP cord-277774-kec1o4ys 28 16 / / SYM cord-277774-kec1o4ys 28 17 l l NN cord-277774-kec1o4ys 28 18 ) ) -RRB- cord-277774-kec1o4ys 28 19 were be VBD cord-277774-kec1o4ys 28 20 observed observe VBN cord-277774-kec1o4ys 28 21 in in IN cord-277774-kec1o4ys 28 22 22 22 CD cord-277774-kec1o4ys 28 23 % % NN cord-277774-kec1o4ys 28 24 and and CC cord-277774-kec1o4ys 28 25 31 31 CD cord-277774-kec1o4ys 28 26 % % NN cord-277774-kec1o4ys 28 27 patients patient NNS cord-277774-kec1o4ys 28 28 , , , cord-277774-kec1o4ys 28 29 respectively respectively RB cord-277774-kec1o4ys 28 30 , , , cord-277774-kec1o4ys 28 31 during during IN cord-277774-kec1o4ys 28 32 treatment treatment NN cord-277774-kec1o4ys 28 33 . . . cord-277774-kec1o4ys 29 1 Furthermore furthermore RB cord-277774-kec1o4ys 29 2 , , , cord-277774-kec1o4ys 29 3 28 28 CD cord-277774-kec1o4ys 29 4 % % NN cord-277774-kec1o4ys 29 5 of of IN cord-277774-kec1o4ys 29 6 patients patient NNS cord-277774-kec1o4ys 29 7 gradually gradually RB cord-277774-kec1o4ys 29 8 worsened worsen VBD cord-277774-kec1o4ys 29 9 and and CC cord-277774-kec1o4ys 29 10 were be VBD cord-277774-kec1o4ys 29 11 diagnosed diagnose VBN cord-277774-kec1o4ys 29 12 with with IN cord-277774-kec1o4ys 29 13 AKI AKI NNP cord-277774-kec1o4ys 29 14 . . . cord-277774-kec1o4ys 30 1 The the DT cord-277774-kec1o4ys 30 2 mortality mortality NN cord-277774-kec1o4ys 30 3 of of IN cord-277774-kec1o4ys 30 4 these these DT cord-277774-kec1o4ys 30 5 patients patient NNS cord-277774-kec1o4ys 30 6 was be VBD cord-277774-kec1o4ys 30 7 5.3-times 5.3-times CD cord-277774-kec1o4ys 30 8 higher high JJR cord-277774-kec1o4ys 30 9 than than IN cord-277774-kec1o4ys 30 10 those those DT cord-277774-kec1o4ys 30 11 without without IN cord-277774-kec1o4ys 30 12 AKI AKI NNP cord-277774-kec1o4ys 30 13 . . . cord-277774-kec1o4ys 31 1 A a DT cord-277774-kec1o4ys 31 2 previous previous JJ cord-277774-kec1o4ys 31 3 study study NN cord-277774-kec1o4ys 31 4 including include VBG cord-277774-kec1o4ys 31 5 536 536 CD cord-277774-kec1o4ys 31 6 patients patient NNS cord-277774-kec1o4ys 31 7 with with IN cord-277774-kec1o4ys 31 8 SARS SARS NNP cord-277774-kec1o4ys 31 9 - - HYPH cord-277774-kec1o4ys 31 10 CoV CoV NNP cord-277774-kec1o4ys 31 11 in in IN cord-277774-kec1o4ys 31 12 Hong Hong NNP cord-277774-kec1o4ys 31 13 Kong Kong NNP cord-277774-kec1o4ys 31 14 in in IN cord-277774-kec1o4ys 31 15 2003 2003 CD cord-277774-kec1o4ys 31 16 showed show VBD cord-277774-kec1o4ys 31 17 that that IN cord-277774-kec1o4ys 31 18 36 36 CD cord-277774-kec1o4ys 31 19 patients patient NNS cord-277774-kec1o4ys 31 20 developed develop VBD cord-277774-kec1o4ys 31 21 AKI AKI NNP cord-277774-kec1o4ys 31 22 after after IN cord-277774-kec1o4ys 31 23 viral viral JJ cord-277774-kec1o4ys 31 24 infection infection NN cord-277774-kec1o4ys 31 25 after after IN cord-277774-kec1o4ys 31 26 a a DT cord-277774-kec1o4ys 31 27 median median NN cord-277774-kec1o4ys 31 28 of of IN cord-277774-kec1o4ys 31 29 20 20 CD cord-277774-kec1o4ys 31 30 days day NNS cord-277774-kec1o4ys 31 31 and and CC cord-277774-kec1o4ys 31 32 33 33 CD cord-277774-kec1o4ys 31 33 ( ( -LRB- cord-277774-kec1o4ys 31 34 91.7 91.7 CD cord-277774-kec1o4ys 31 35 % % NN cord-277774-kec1o4ys 31 36 ) ) -RRB- cord-277774-kec1o4ys 31 37 of of IN cord-277774-kec1o4ys 31 38 them -PRON- PRP cord-277774-kec1o4ys 31 39 died die VBD cord-277774-kec1o4ys 31 40 3 3 CD cord-277774-kec1o4ys 31 41 . . . cord-277774-kec1o4ys 32 1 These these DT cord-277774-kec1o4ys 32 2 results result NNS cord-277774-kec1o4ys 32 3 indicate indicate VBP cord-277774-kec1o4ys 32 4 that that IN cord-277774-kec1o4ys 32 5 development development NN cord-277774-kec1o4ys 32 6 of of IN cord-277774-kec1o4ys 32 7 AKI AKI NNP cord-277774-kec1o4ys 32 8 in in IN cord-277774-kec1o4ys 32 9 patients patient NNS cord-277774-kec1o4ys 32 10 with with IN cord-277774-kec1o4ys 32 11 COVID-19 COVID-19 NNP cord-277774-kec1o4ys 32 12 might may MD cord-277774-kec1o4ys 32 13 be be VB cord-277774-kec1o4ys 32 14 a a DT cord-277774-kec1o4ys 32 15 crucial crucial JJ cord-277774-kec1o4ys 32 16 negative negative JJ cord-277774-kec1o4ys 32 17 prognostic prognostic JJ cord-277774-kec1o4ys 32 18 factor factor NN cord-277774-kec1o4ys 32 19 for for IN cord-277774-kec1o4ys 32 20 survival survival NN cord-277774-kec1o4ys 32 21 . . . cord-277774-kec1o4ys 33 1 Li Li NNP cord-277774-kec1o4ys 33 2 and and CC cord-277774-kec1o4ys 33 3 colleagues colleague NNS cord-277774-kec1o4ys 33 4 1 1 CD cord-277774-kec1o4ys 33 5 also also RB cord-277774-kec1o4ys 33 6 showed show VBD cord-277774-kec1o4ys 33 7 that that IN cord-277774-kec1o4ys 33 8 patients patient NNS cord-277774-kec1o4ys 33 9 with with IN cord-277774-kec1o4ys 33 10 severe severe JJ cord-277774-kec1o4ys 33 11 COVID-19 covid-19 NN cord-277774-kec1o4ys 33 12 are be VBP cord-277774-kec1o4ys 33 13 at at IN cord-277774-kec1o4ys 33 14 increased increase VBN cord-277774-kec1o4ys 33 15 risk risk NN cord-277774-kec1o4ys 33 16 of of IN cord-277774-kec1o4ys 33 17 kidney kidney NN cord-277774-kec1o4ys 33 18 impairment impairment NN cord-277774-kec1o4ys 33 19 . . . cord-277774-kec1o4ys 34 1 The the DT cord-277774-kec1o4ys 34 2 level level NN cord-277774-kec1o4ys 34 3 of of IN cord-277774-kec1o4ys 34 4 SCr scr NN cord-277774-kec1o4ys 34 5 in in IN cord-277774-kec1o4ys 34 6 patients patient NNS cord-277774-kec1o4ys 34 7 with with IN cord-277774-kec1o4ys 34 8 severe severe JJ cord-277774-kec1o4ys 34 9 COVID-19 covid-19 NN cord-277774-kec1o4ys 34 10 was be VBD cord-277774-kec1o4ys 34 11 significantly significantly RB cord-277774-kec1o4ys 34 12 higher high JJR cord-277774-kec1o4ys 34 13 than than IN cord-277774-kec1o4ys 34 14 in in IN cord-277774-kec1o4ys 34 15 those those DT cord-277774-kec1o4ys 34 16 without without IN cord-277774-kec1o4ys 34 17 severe severe JJ cord-277774-kec1o4ys 34 18 disease disease NN cord-277774-kec1o4ys 34 19 ( ( -LRB- cord-277774-kec1o4ys 34 20 P p NN cord-277774-kec1o4ys 34 21 < < XX cord-277774-kec1o4ys 34 22 0.001 0.001 CD cord-277774-kec1o4ys 34 23 ) ) -RRB- cord-277774-kec1o4ys 34 24 , , , cord-277774-kec1o4ys 34 25 whereas whereas IN cord-277774-kec1o4ys 34 26 patients patient NNS cord-277774-kec1o4ys 34 27 with with IN cord-277774-kec1o4ys 34 28 mild mild JJ cord-277774-kec1o4ys 34 29 COVID-19 COVID-19 NNP cord-277774-kec1o4ys 34 30 had have VBD cord-277774-kec1o4ys 34 31 higher high JJR cord-277774-kec1o4ys 34 32 SCr scr NN cord-277774-kec1o4ys 34 33 levels level NNS cord-277774-kec1o4ys 34 34 than than IN cord-277774-kec1o4ys 34 35 patients patient NNS cord-277774-kec1o4ys 34 36 with with IN cord-277774-kec1o4ys 34 37 non non JJ cord-277774-kec1o4ys 34 38 - - JJ cord-277774-kec1o4ys 34 39 COVID-19associated covid-19associated JJ cord-277774-kec1o4ys 34 40 pneumonia pneumonia NN cord-277774-kec1o4ys 35 1 ( ( -LRB- cord-277774-kec1o4ys 35 2 P p NN cord-277774-kec1o4ys 35 3 < < XX cord-277774-kec1o4ys 35 4 0.01 0.01 CD cord-277774-kec1o4ys 35 5 ) ) -RRB- cord-277774-kec1o4ys 35 6 . . . cord-277774-kec1o4ys 36 1 AKI AKI NNP cord-277774-kec1o4ys 36 2 requiring require VBG cord-277774-kec1o4ys 36 3 CRRT CRRT NNP cord-277774-kec1o4ys 36 4 occurred occur VBD cord-277774-kec1o4ys 36 5 in in IN cord-277774-kec1o4ys 36 6 7 7 CD cord-277774-kec1o4ys 36 7 of of IN cord-277774-kec1o4ys 36 8 the the DT cord-277774-kec1o4ys 36 9 65 65 CD cord-277774-kec1o4ys 36 10 patients patient NNS cord-277774-kec1o4ys 36 11 with with IN cord-277774-kec1o4ys 36 12 severe severe JJ cord-277774-kec1o4ys 36 13 disease disease NN cord-277774-kec1o4ys 36 14 , , , cord-277774-kec1o4ys 36 15 but but CC cord-277774-kec1o4ys 36 16 in in IN cord-277774-kec1o4ys 36 17 none none NN cord-277774-kec1o4ys 36 18 of of IN cord-277774-kec1o4ys 36 19 the the DT cord-277774-kec1o4ys 36 20 other other JJ cord-277774-kec1o4ys 36 21 patients patient NNS cord-277774-kec1o4ys 36 22 included include VBN cord-277774-kec1o4ys 36 23 in in IN cord-277774-kec1o4ys 36 24 this this DT cord-277774-kec1o4ys 36 25 study study NN cord-277774-kec1o4ys 36 26 . . . cord-277774-kec1o4ys 37 1 In in IN cord-277774-kec1o4ys 37 2 another another DT cord-277774-kec1o4ys 37 3 study study NN cord-277774-kec1o4ys 37 4 , , , cord-277774-kec1o4ys 37 5 histopathological histopathological JJ cord-277774-kec1o4ys 37 6 examination examination NN cord-277774-kec1o4ys 37 7 was be VBD cord-277774-kec1o4ys 37 8 undertaken undertake VBN cord-277774-kec1o4ys 37 9 on on IN cord-277774-kec1o4ys 37 10 autopsy autopsy JJ cord-277774-kec1o4ys 37 11 kidney kidney NN cord-277774-kec1o4ys 37 12 samples sample NNS cord-277774-kec1o4ys 37 13 from from IN cord-277774-kec1o4ys 37 14 six six CD cord-277774-kec1o4ys 37 15 patients patient NNS cord-277774-kec1o4ys 37 16 with with IN cord-277774-kec1o4ys 37 17 COVID-19 COVID-19 NNP cord-277774-kec1o4ys 37 18 who who WP cord-277774-kec1o4ys 37 19 had have VBD cord-277774-kec1o4ys 37 20 impaired impair VBN cord-277774-kec1o4ys 37 21 renal renal JJ cord-277774-kec1o4ys 37 22 function function NN cord-277774-kec1o4ys 37 23 before before IN cord-277774-kec1o4ys 37 24 their -PRON- PRP$ cord-277774-kec1o4ys 37 25 death death NN cord-277774-kec1o4ys 37 26 3 3 CD cord-277774-kec1o4ys 37 27 . . . cord-277774-kec1o4ys 38 1 Acute acute JJ cord-277774-kec1o4ys 38 2 renal renal JJ cord-277774-kec1o4ys 38 3 tubular tubular JJ cord-277774-kec1o4ys 38 4 damage damage NN cord-277774-kec1o4ys 38 5 ( ( -LRB- cord-277774-kec1o4ys 38 6 but but CC cord-277774-kec1o4ys 38 7 not not RB cord-277774-kec1o4ys 38 8 glomerular glomerular JJ cord-277774-kec1o4ys 38 9 injury injury NN cord-277774-kec1o4ys 38 10 ) ) -RRB- cord-277774-kec1o4ys 38 11 was be VBD cord-277774-kec1o4ys 38 12 seen see VBN cord-277774-kec1o4ys 38 13 in in IN cord-277774-kec1o4ys 38 14 all all DT cord-277774-kec1o4ys 38 15 six six CD cord-277774-kec1o4ys 38 16 patients patient NNS cord-277774-kec1o4ys 38 17 and and CC cord-277774-kec1o4ys 38 18 acute acute JJ cord-277774-kec1o4ys 38 19 tubular tubular JJ cord-277774-kec1o4ys 38 20 necrosis necrosis NN cord-277774-kec1o4ys 38 21 , , , cord-277774-kec1o4ys 38 22 luminal luminal JJ cord-277774-kec1o4ys 38 23 brush brush NN cord-277774-kec1o4ys 38 24 border border NN cord-277774-kec1o4ys 38 25 sloughing sloughing NN cord-277774-kec1o4ys 38 26 and and CC cord-277774-kec1o4ys 38 27 vacuole vacuole NN cord-277774-kec1o4ys 38 28 degeneration degeneration NN cord-277774-kec1o4ys 38 29 were be VBD cord-277774-kec1o4ys 38 30 observed observe VBN cord-277774-kec1o4ys 38 31 to to IN cord-277774-kec1o4ys 38 32 varying vary VBG cord-277774-kec1o4ys 38 33 degrees degree NNS cord-277774-kec1o4ys 38 34 . . . cord-277774-kec1o4ys 39 1 Similar similar JJ cord-277774-kec1o4ys 39 2 findings finding NNS cord-277774-kec1o4ys 39 3 were be VBD cord-277774-kec1o4ys 39 4 also also RB cord-277774-kec1o4ys 39 5 observed observe VBN cord-277774-kec1o4ys 39 6 in in IN cord-277774-kec1o4ys 39 7 autopsy autopsy JJ cord-277774-kec1o4ys 39 8 kidney kidney NN cord-277774-kec1o4ys 39 9 samples sample NNS cord-277774-kec1o4ys 39 10 from from IN cord-277774-kec1o4ys 39 11 patients patient NNS cord-277774-kec1o4ys 39 12 with with IN cord-277774-kec1o4ys 39 13 MERS MERS NNP cord-277774-kec1o4ys 39 14 - - HYPH cord-277774-kec1o4ys 39 15 CoV CoV NNP cord-277774-kec1o4ys 39 16 infection infection NN cord-277774-kec1o4ys 39 17 4 4 CD cord-277774-kec1o4ys 39 18 , , , cord-277774-kec1o4ys 39 19 which which WDT cord-277774-kec1o4ys 39 20 showed show VBD cord-277774-kec1o4ys 39 21 degeneration degeneration NN cord-277774-kec1o4ys 39 22 of of IN cord-277774-kec1o4ys 39 23 the the DT cord-277774-kec1o4ys 39 24 renal renal JJ cord-277774-kec1o4ys 39 25 tubules tubule NNS cord-277774-kec1o4ys 39 26 , , , cord-277774-kec1o4ys 39 27 including include VBG cord-277774-kec1o4ys 39 28 ectasia ectasia JJ cord-277774-kec1o4ys 39 29 changes change NNS cord-277774-kec1o4ys 39 30 and and CC cord-277774-kec1o4ys 39 31 necrosis necrosis NN cord-277774-kec1o4ys 39 32 , , , cord-277774-kec1o4ys 39 33 sloughing slough VBG cord-277774-kec1o4ys 39 34 , , , cord-277774-kec1o4ys 39 35 and and CC cord-277774-kec1o4ys 39 36 loss loss NN cord-277774-kec1o4ys 39 37 of of IN cord-277774-kec1o4ys 39 38 brush brush NN cord-277774-kec1o4ys 39 39 surface surface NN cord-277774-kec1o4ys 39 40 in in IN cord-277774-kec1o4ys 39 41 the the DT cord-277774-kec1o4ys 39 42 proximal proximal JJ cord-277774-kec1o4ys 39 43 tubular tubular JJ cord-277774-kec1o4ys 39 44 epithelial epithelial JJ cord-277774-kec1o4ys 39 45 cells cell NNS cord-277774-kec1o4ys 39 46 . . . cord-277774-kec1o4ys 40 1 These these DT cord-277774-kec1o4ys 40 2 results result NNS cord-277774-kec1o4ys 40 3 suggest suggest VBP cord-277774-kec1o4ys 40 4 that that IN cord-277774-kec1o4ys 40 5 the the DT cord-277774-kec1o4ys 40 6 renal renal JJ cord-277774-kec1o4ys 40 7 tubules tubule NNS cord-277774-kec1o4ys 40 8 are be VBP cord-277774-kec1o4ys 40 9 a a DT cord-277774-kec1o4ys 40 10 common common JJ cord-277774-kec1o4ys 40 11 target target NN cord-277774-kec1o4ys 40 12 of of IN cord-277774-kec1o4ys 40 13 infection infection NN cord-277774-kec1o4ys 40 14 . . . cord-277774-kec1o4ys 41 1 As as IN cord-277774-kec1o4ys 41 2 SARS SARS NNP cord-277774-kec1o4ys 41 3 - - HYPH cord-277774-kec1o4ys 41 4 CoV-2 CoV-2 NNP cord-277774-kec1o4ys 41 5 , , , cord-277774-kec1o4ys 41 6 SARS SARS NNP cord-277774-kec1o4ys 41 7 - - HYPH cord-277774-kec1o4ys 41 8 CoV CoV NNP cord-277774-kec1o4ys 41 9 and and CC cord-277774-kec1o4ys 41 10 MERS MERS NNP cord-277774-kec1o4ys 41 11 - - HYPH cord-277774-kec1o4ys 41 12 CoV CoV NNP cord-277774-kec1o4ys 41 13 have have VBP cord-277774-kec1o4ys 41 14 similar similar JJ cord-277774-kec1o4ys 41 15 pathogenicity pathogenicity NN cord-277774-kec1o4ys 41 16 , , , cord-277774-kec1o4ys 41 17 comprehensive comprehensive JJ cord-277774-kec1o4ys 41 18 analysis analysis NN cord-277774-kec1o4ys 41 19 of of IN cord-277774-kec1o4ys 41 20 kidney kidney NN cord-277774-kec1o4ys 41 21 injury injury NN cord-277774-kec1o4ys 41 22 in in IN cord-277774-kec1o4ys 41 23 patients patient NNS cord-277774-kec1o4ys 41 24 with with IN cord-277774-kec1o4ys 41 25 SARS SARS NNP cord-277774-kec1o4ys 41 26 - - HYPH cord-277774-kec1o4ys 41 27 CoV CoV NNP cord-277774-kec1o4ys 41 28 or or CC cord-277774-kec1o4ys 41 29 MERS MERS NNP cord-277774-kec1o4ys 41 30 - - HYPH cord-277774-kec1o4ys 41 31 CoV CoV NNP cord-277774-kec1o4ys 41 32 should should MD cord-277774-kec1o4ys 41 33 be be VB cord-277774-kec1o4ys 41 34 undertaken undertake VBN cord-277774-kec1o4ys 41 35 to to TO cord-277774-kec1o4ys 41 36 improve improve VB cord-277774-kec1o4ys 41 37 our -PRON- PRP$ cord-277774-kec1o4ys 41 38 understanding understanding NN cord-277774-kec1o4ys 41 39 of of IN cord-277774-kec1o4ys 41 40 the the DT cord-277774-kec1o4ys 41 41 possible possible JJ cord-277774-kec1o4ys 41 42 outcomes outcome NNS cord-277774-kec1o4ys 41 43 . . . cord-277774-kec1o4ys 42 1 Pre pre JJ cord-277774-kec1o4ys 42 2 - - JJ cord-277774-kec1o4ys 42 3 existing existing JJ cord-277774-kec1o4ys 42 4 chronic chronic JJ cord-277774-kec1o4ys 42 5 kidney kidney NN cord-277774-kec1o4ys 42 6 disease disease NN cord-277774-kec1o4ys 42 7 Chronic chronic JJ cord-277774-kec1o4ys 42 8 kidney kidney NN cord-277774-kec1o4ys 42 9 disease disease NN cord-277774-kec1o4ys 42 10 ( ( -LRB- cord-277774-kec1o4ys 42 11 CKD CKD NNP cord-277774-kec1o4ys 42 12 ) ) -RRB- cord-277774-kec1o4ys 42 13 might may MD cord-277774-kec1o4ys 42 14 increase increase VB cord-277774-kec1o4ys 42 15 the the DT cord-277774-kec1o4ys 42 16 risk risk NN cord-277774-kec1o4ys 42 17 of of IN cord-277774-kec1o4ys 42 18 poor poor JJ cord-277774-kec1o4ys 42 19 clinical clinical JJ cord-277774-kec1o4ys 42 20 outcomes outcome NNS cord-277774-kec1o4ys 42 21 in in IN cord-277774-kec1o4ys 42 22 patients patient NNS cord-277774-kec1o4ys 42 23 with with IN cord-277774-kec1o4ys 42 24 COVID-19 COVID-19 NNP cord-277774-kec1o4ys 42 25 . . . cord-277774-kec1o4ys 43 1 A a DT cord-277774-kec1o4ys 43 2 study study NN cord-277774-kec1o4ys 43 3 including include VBG cord-277774-kec1o4ys 43 4 116 116 CD cord-277774-kec1o4ys 43 5 patients patient NNS cord-277774-kec1o4ys 43 6 with with IN cord-277774-kec1o4ys 43 7 MERS MERS NNP cord-277774-kec1o4ys 43 8 - - HYPH cord-277774-kec1o4ys 43 9 CoV CoV NNP cord-277774-kec1o4ys 43 10 using use VBG cord-277774-kec1o4ys 43 11 regression regression NN cord-277774-kec1o4ys 43 12 modelling modelling NN cord-277774-kec1o4ys 43 13 showed show VBD cord-277774-kec1o4ys 43 14 that that IN cord-277774-kec1o4ys 43 15 CKD CKD NNP cord-277774-kec1o4ys 43 16 was be VBD cord-277774-kec1o4ys 43 17 the the DT cord-277774-kec1o4ys 43 18 best good JJS cord-277774-kec1o4ys 43 19 Effects effect NNS cord-277774-kec1o4ys 43 20 on on IN cord-277774-kec1o4ys 43 21 the the DT cord-277774-kec1o4ys 43 22 testes testis NNS cord-277774-kec1o4ys 43 23 Viruses virus NNS cord-277774-kec1o4ys 43 24 such such JJ cord-277774-kec1o4ys 43 25 as as IN cord-277774-kec1o4ys 43 26 HIV HIV NNP cord-277774-kec1o4ys 43 27 , , , cord-277774-kec1o4ys 43 28 hepatitis hepatitis NN cord-277774-kec1o4ys 43 29 B B NNP cord-277774-kec1o4ys 43 30 and and CC cord-277774-kec1o4ys 43 31 C C NNP cord-277774-kec1o4ys 43 32 , , , cord-277774-kec1o4ys 43 33 mumps mumps NN cord-277774-kec1o4ys 43 34 , , , cord-277774-kec1o4ys 43 35 Epstein Epstein NNP cord-277774-kec1o4ys 43 36 - - HYPH cord-277774-kec1o4ys 43 37 Barr Barr NNP cord-277774-kec1o4ys 43 38 and and CC cord-277774-kec1o4ys 43 39 papilloma papilloma NN cord-277774-kec1o4ys 43 40 can can MD cord-277774-kec1o4ys 43 41 cause cause VB cord-277774-kec1o4ys 43 42 viral viral JJ cord-277774-kec1o4ys 43 43 orchitis orchitis NN cord-277774-kec1o4ys 43 44 and and CC cord-277774-kec1o4ys 43 45 even even RB cord-277774-kec1o4ys 43 46 lead lead VBP cord-277774-kec1o4ys 43 47 to to IN cord-277774-kec1o4ys 43 48 male male JJ cord-277774-kec1o4ys 43 49 infertility infertility NN cord-277774-kec1o4ys 43 50 and and CC cord-277774-kec1o4ys 43 51 testicular testicular JJ cord-277774-kec1o4ys 43 52 tumours tumour NNS cord-277774-kec1o4ys 43 53 6 6 CD cord-277774-kec1o4ys 43 54 . . . cord-277774-kec1o4ys 44 1 One one CD cord-277774-kec1o4ys 44 2 study study NN cord-277774-kec1o4ys 44 3 in in IN cord-277774-kec1o4ys 44 4 testis testis NN cord-277774-kec1o4ys 44 5 autopsy autopsy JJ cord-277774-kec1o4ys 44 6 specimens specimen NNS cord-277774-kec1o4ys 44 7 obtained obtain VBN cord-277774-kec1o4ys 44 8 from from IN cord-277774-kec1o4ys 44 9 six six CD cord-277774-kec1o4ys 44 10 patients patient NNS cord-277774-kec1o4ys 44 11 who who WP cord-277774-kec1o4ys 44 12 died die VBD cord-277774-kec1o4ys 44 13 of of IN cord-277774-kec1o4ys 44 14 SARS SARS NNP cord-277774-kec1o4ys 44 15 - - HYPH cord-277774-kec1o4ys 44 16 CoV CoV NNP cord-277774-kec1o4ys 45 1 showed show VBD cord-277774-kec1o4ys 45 2 that that IN cord-277774-kec1o4ys 45 3 this this DT cord-277774-kec1o4ys 45 4 virus virus NN cord-277774-kec1o4ys 45 5 can can MD cord-277774-kec1o4ys 45 6 induce induce VB cord-277774-kec1o4ys 45 7 orchitis orchitis NN cord-277774-kec1o4ys 45 8 6 6 CD cord-277774-kec1o4ys 45 9 . . . cord-277774-kec1o4ys 46 1 Pathological pathological JJ cord-277774-kec1o4ys 46 2 results result NNS cord-277774-kec1o4ys 46 3 showed show VBD cord-277774-kec1o4ys 46 4 spermatogenic spermatogenic JJ cord-277774-kec1o4ys 46 5 cell cell NN cord-277774-kec1o4ys 46 6 apoptosis apoptosis NN cord-277774-kec1o4ys 46 7 , , , cord-277774-kec1o4ys 46 8 germ germ NN cord-277774-kec1o4ys 46 9 cell cell NN cord-277774-kec1o4ys 46 10 destruction destruction NN cord-277774-kec1o4ys 46 11 , , , cord-277774-kec1o4ys 46 12 few few JJ cord-277774-kec1o4ys 46 13 or or CC cord-277774-kec1o4ys 46 14 no no DT cord-277774-kec1o4ys 46 15 spermatozoa spermatozoa NN cord-277774-kec1o4ys 46 16 in in IN cord-277774-kec1o4ys 46 17 the the DT cord-277774-kec1o4ys 46 18 seminiferous seminiferous JJ cord-277774-kec1o4ys 46 19 epithelium epithelium NN cord-277774-kec1o4ys 46 20 , , , cord-277774-kec1o4ys 46 21 thickened thickened JJ cord-277774-kec1o4ys 46 22 basement basement NN cord-277774-kec1o4ys 46 23 membrane membrane NN cord-277774-kec1o4ys 46 24 and and CC cord-277774-kec1o4ys 46 25 leukocyte leukocyte NN cord-277774-kec1o4ys 46 26 infiltration infiltration NN cord-277774-kec1o4ys 46 27 in in IN cord-277774-kec1o4ys 46 28 all all DT cord-277774-kec1o4ys 46 29 six six CD cord-277774-kec1o4ys 46 30 specimens specimen NNS cord-277774-kec1o4ys 46 31 . . . cord-277774-kec1o4ys 47 1 Thus thus RB cord-277774-kec1o4ys 47 2 , , , cord-277774-kec1o4ys 47 3 the the DT cord-277774-kec1o4ys 47 4 testes testis NNS cord-277774-kec1o4ys 47 5 could could MD cord-277774-kec1o4ys 47 6 be be VB cord-277774-kec1o4ys 47 7 affected affect VBN cord-277774-kec1o4ys 47 8 by by IN cord-277774-kec1o4ys 47 9 SARS SARS NNP cord-277774-kec1o4ys 47 10 - - HYPH cord-277774-kec1o4ys 47 11 CoV-2 CoV-2 NNP cord-277774-kec1o4ys 47 12 . . . cord-277774-kec1o4ys 48 1 A a DT cord-277774-kec1o4ys 48 2 recent recent JJ cord-277774-kec1o4ys 48 3 study study NN cord-277774-kec1o4ys 48 4 provides provide VBZ cord-277774-kec1o4ys 48 5 insights insight NNS cord-277774-kec1o4ys 48 6 into into IN cord-277774-kec1o4ys 48 7 impaired impaired JJ cord-277774-kec1o4ys 48 8 male male JJ cord-277774-kec1o4ys 48 9 gonadal gonadal JJ cord-277774-kec1o4ys 48 10 function function NN cord-277774-kec1o4ys 48 11 on on IN cord-277774-kec1o4ys 48 12 SARS SARS NNP cord-277774-kec1o4ys 48 13 - - HYPH cord-277774-kec1o4ys 48 14 CoV-2 CoV-2 NNP cord-277774-kec1o4ys 48 15 infection infection NN cord-277774-kec1o4ys 48 16 2 2 CD cord-277774-kec1o4ys 48 17 . . . cord-277774-kec1o4ys 49 1 This this DT cord-277774-kec1o4ys 49 2 study study NN cord-277774-kec1o4ys 49 3 showed show VBD cord-277774-kec1o4ys 49 4 that that IN cord-277774-kec1o4ys 49 5 the the DT cord-277774-kec1o4ys 49 6 testosterone testosterone NN cord-277774-kec1o4ys 49 7 to to IN cord-277774-kec1o4ys 49 8 luteinizing luteinize VBG cord-277774-kec1o4ys 49 9 hormone hormone NN cord-277774-kec1o4ys 49 10 ( ( -LRB- cord-277774-kec1o4ys 49 11 T T NNP cord-277774-kec1o4ys 49 12 to to IN cord-277774-kec1o4ys 49 13 LH lh NN cord-277774-kec1o4ys 49 14 ) ) -RRB- cord-277774-kec1o4ys 49 15 ratio ratio NN cord-277774-kec1o4ys 49 16 in in IN cord-277774-kec1o4ys 49 17 81 81 CD cord-277774-kec1o4ys 49 18 patients patient NNS cord-277774-kec1o4ys 49 19 with with IN cord-277774-kec1o4ys 49 20 COVID-19 COVID-19 NNP cord-277774-kec1o4ys 49 21 was be VBD cord-277774-kec1o4ys 49 22 dramatically dramatically RB cord-277774-kec1o4ys 49 23 decreased decrease VBN cord-277774-kec1o4ys 49 24 in in IN cord-277774-kec1o4ys 49 25 comparison comparison NN cord-277774-kec1o4ys 49 26 with with IN cord-277774-kec1o4ys 49 27 100 100 CD cord-277774-kec1o4ys 49 28 age age NN cord-277774-kec1o4ys 49 29 - - HYPH cord-277774-kec1o4ys 49 30 matched match VBN cord-277774-kec1o4ys 49 31 healthy healthy JJ cord-277774-kec1o4ys 49 32 counterparts counterpart NNS cord-277774-kec1o4ys 49 33 ( ( -LRB- cord-277774-kec1o4ys 49 34 patients patient NNS cord-277774-kec1o4ys 49 35 with with IN cord-277774-kec1o4ys 49 36 COVID-19 covid-19 NN cord-277774-kec1o4ys 49 37 : : : cord-277774-kec1o4ys 49 38 0.74 0.74 CD cord-277774-kec1o4ys 49 39 ; ; : cord-277774-kec1o4ys 49 40 healthy healthy JJ cord-277774-kec1o4ys 49 41 men man NNS cord-277774-kec1o4ys 49 42 : : : cord-277774-kec1o4ys 49 43 1.31 1.31 CD cord-277774-kec1o4ys 49 44 , , , cord-277774-kec1o4ys 49 45 P p NN cord-277774-kec1o4ys 49 46 < < XX cord-277774-kec1o4ys 49 47 0.0001 0.0001 CD cord-277774-kec1o4ys 49 48 ) ) -RRB- cord-277774-kec1o4ys 49 49 . . . cord-277774-kec1o4ys 50 1 Serum serum NN cord-277774-kec1o4ys 50 2 T t NN cord-277774-kec1o4ys 50 3 to to IN cord-277774-kec1o4ys 50 4 LH lh NN cord-277774-kec1o4ys 50 5 ratio ratio NN cord-277774-kec1o4ys 50 6 ( ( -LRB- cord-277774-kec1o4ys 50 7 as as IN cord-277774-kec1o4ys 50 8 a a DT cord-277774-kec1o4ys 50 9 predictor predictor NN cord-277774-kec1o4ys 50 10 of of IN cord-277774-kec1o4ys 50 11 male male JJ cord-277774-kec1o4ys 50 12 gonadal gonadal JJ cord-277774-kec1o4ys 50 13 function function NN cord-277774-kec1o4ys 50 14 ) ) -RRB- cord-277774-kec1o4ys 50 15 could could MD cord-277774-kec1o4ys 50 16 be be VB cord-277774-kec1o4ys 50 17 a a DT cord-277774-kec1o4ys 50 18 potential potential JJ cord-277774-kec1o4ys 50 19 marker marker NN cord-277774-kec1o4ys 50 20 of of IN cord-277774-kec1o4ys 50 21 impairment impairment NN cord-277774-kec1o4ys 50 22 of of IN cord-277774-kec1o4ys 50 23 reproductive reproductive JJ cord-277774-kec1o4ys 50 24 health health NN cord-277774-kec1o4ys 50 25 by by IN cord-277774-kec1o4ys 50 26 SARS SARS NNP cord-277774-kec1o4ys 50 27 - - HYPH cord-277774-kec1o4ys 50 28 CoV-2 CoV-2 NNP cord-277774-kec1o4ys 50 29 ( ( -LRB- cord-277774-kec1o4ys 50 30 REF ref NN cord-277774-kec1o4ys 50 31 . . . cord-277774-kec1o4ys 50 32 2 2 LS cord-277774-kec1o4ys 50 33 ) ) -RRB- cord-277774-kec1o4ys 50 34 . . . cord-277774-kec1o4ys 51 1 Consistent consistent JJ cord-277774-kec1o4ys 51 2 with with IN cord-277774-kec1o4ys 51 3 SARS SARS NNP cord-277774-kec1o4ys 51 4 - - HYPH cord-277774-kec1o4ys 51 5 CoV CoV NNP cord-277774-kec1o4ys 51 6 , , , cord-277774-kec1o4ys 51 7 SARS SARS NNP cord-277774-kec1o4ys 51 8 - - HYPH cord-277774-kec1o4ys 51 9 CoV-2 CoV-2 NNP cord-277774-kec1o4ys 51 10 viral viral JJ cord-277774-kec1o4ys 51 11 nucleoprotein nucleoprotein JJ cord-277774-kec1o4ys 51 12 antigen antigen NNP cord-277774-kec1o4ys 51 13 has have VBZ cord-277774-kec1o4ys 51 14 been be VBN cord-277774-kec1o4ys 51 15 observed observe VBN cord-277774-kec1o4ys 51 16 to to TO cord-277774-kec1o4ys 51 17 have have VB cord-277774-kec1o4ys 51 18 expression expression NN cord-277774-kec1o4ys 51 19 restricted restrict VBN cord-277774-kec1o4ys 51 20 to to IN cord-277774-kec1o4ys 51 21 renal renal JJ cord-277774-kec1o4ys 51 22 tubular tubular JJ cord-277774-kec1o4ys 51 23 epithelial epithelial JJ cord-277774-kec1o4ys 51 24 cells cell NNS cord-277774-kec1o4ys 51 25 7 7 CD cord-277774-kec1o4ys 51 26 . . . cord-277774-kec1o4ys 52 1 MERS MERS NNP cord-277774-kec1o4ys 52 2 - - HYPH cord-277774-kec1o4ys 52 3 CoV cov NN cord-277774-kec1o4ys 52 4 particles particle NNS cord-277774-kec1o4ys 52 5 have have VBP cord-277774-kec1o4ys 52 6 also also RB cord-277774-kec1o4ys 52 7 been be VBN cord-277774-kec1o4ys 52 8 detected detect VBN cord-277774-kec1o4ys 52 9 in in IN cord-277774-kec1o4ys 52 10 renal renal JJ cord-277774-kec1o4ys 52 11 proximal proximal JJ cord-277774-kec1o4ys 52 12 tubular tubular JJ cord-277774-kec1o4ys 52 13 epithelial epithelial JJ cord-277774-kec1o4ys 52 14 cells cell NNS cord-277774-kec1o4ys 52 15 in in IN cord-277774-kec1o4ys 52 16 renal renal JJ cord-277774-kec1o4ys 52 17 autopsy autopsy JJ cord-277774-kec1o4ys 52 18 samples sample NNS cord-277774-kec1o4ys 52 19 4 4 CD cord-277774-kec1o4ys 52 20 . . . cord-277774-kec1o4ys 53 1 Surprisingly surprisingly RB cord-277774-kec1o4ys 53 2 , , , cord-277774-kec1o4ys 53 3 SARS SARS NNP cord-277774-kec1o4ys 53 4 - - HYPH cord-277774-kec1o4ys 53 5 CoV cov NN cord-277774-kec1o4ys 53 6 particles particle NNS cord-277774-kec1o4ys 53 7 were be VBD cord-277774-kec1o4ys 53 8 identified identify VBN cord-277774-kec1o4ys 53 9 in in IN cord-277774-kec1o4ys 53 10 the the DT cord-277774-kec1o4ys 53 11 epithelial epithelial JJ cord-277774-kec1o4ys 53 12 cells cell NNS cord-277774-kec1o4ys 53 13 of of IN cord-277774-kec1o4ys 53 14 testicular testicular JJ cord-277774-kec1o4ys 53 15 seminiferous seminiferous JJ cord-277774-kec1o4ys 53 16 tubules tubule NNS cord-277774-kec1o4ys 53 17 and and CC cord-277774-kec1o4ys 53 18 Leydig leydig NN cord-277774-kec1o4ys 53 19 cells cell NNS cord-277774-kec1o4ys 53 20 , , , cord-277774-kec1o4ys 53 21 providing provide VBG cord-277774-kec1o4ys 53 22 direct direct JJ cord-277774-kec1o4ys 53 23 evidence evidence NN cord-277774-kec1o4ys 53 24 of of IN cord-277774-kec1o4ys 53 25 viral viral JJ cord-277774-kec1o4ys 53 26 testicular testicular JJ cord-277774-kec1o4ys 53 27 damage damage NN cord-277774-kec1o4ys 53 28 8 8 CD cord-277774-kec1o4ys 53 29 . . . cord-277774-kec1o4ys 54 1 Molecular molecular JJ cord-277774-kec1o4ys 54 2 studies study NNS cord-277774-kec1o4ys 54 3 on on IN cord-277774-kec1o4ys 54 4 mechanisms mechanism NNS cord-277774-kec1o4ys 54 5 of of IN cord-277774-kec1o4ys 54 6 coronavirus coronavirus NN cord-277774-kec1o4ys 54 7 infection infection NN cord-277774-kec1o4ys 54 8 have have VBP cord-277774-kec1o4ys 54 9 shown show VBN cord-277774-kec1o4ys 54 10 that that IN cord-277774-kec1o4ys 54 11 coronaviruses coronaviruse NNS cord-277774-kec1o4ys 54 12 rely rely VB cord-277774-kec1o4ys 54 13 on on IN cord-277774-kec1o4ys 54 14 the the DT cord-277774-kec1o4ys 54 15 binding binding NN cord-277774-kec1o4ys 54 16 of of IN cord-277774-kec1o4ys 54 17 viral viral JJ cord-277774-kec1o4ys 54 18 spike spike NN cord-277774-kec1o4ys 54 19 proteins protein NNS cord-277774-kec1o4ys 54 20 to to IN cord-277774-kec1o4ys 54 21 cellular cellular JJ cord-277774-kec1o4ys 54 22 receptors receptor NNS cord-277774-kec1o4ys 54 23 and and CC cord-277774-kec1o4ys 54 24 on on IN cord-277774-kec1o4ys 54 25 spike spike NN cord-277774-kec1o4ys 54 26 protein protein NN cord-277774-kec1o4ys 54 27 priming prime VBG cord-277774-kec1o4ys 54 28 by by IN cord-277774-kec1o4ys 54 29 host host NN cord-277774-kec1o4ys 54 30 cell cell NN cord-277774-kec1o4ys 54 31 proteases protease NNS cord-277774-kec1o4ys 54 32 to to TO cord-277774-kec1o4ys 54 33 enter enter VB cord-277774-kec1o4ys 54 34 a a DT cord-277774-kec1o4ys 54 35 cell cell NN cord-277774-kec1o4ys 54 36 . . . cord-277774-kec1o4ys 55 1 SARS SARS NNP cord-277774-kec1o4ys 55 2 - - HYPH cord-277774-kec1o4ys 55 3 CoV-2 CoV-2 NNP cord-277774-kec1o4ys 55 4 binds bind VBZ cord-277774-kec1o4ys 55 5 to to IN cord-277774-kec1o4ys 55 6 the the DT cord-277774-kec1o4ys 55 7 angiotensin angiotensin NN cord-277774-kec1o4ys 55 8 - - HYPH cord-277774-kec1o4ys 55 9 converting convert VBG cord-277774-kec1o4ys 55 10 enzyme enzyme NN cord-277774-kec1o4ys 55 11 2 2 CD cord-277774-kec1o4ys 55 12 ( ( -LRB- cord-277774-kec1o4ys 55 13 ACE2 ACE2 NNP cord-277774-kec1o4ys 55 14 ) ) -RRB- cord-277774-kec1o4ys 55 15 receptor receptor NN cord-277774-kec1o4ys 55 16 for for IN cord-277774-kec1o4ys 55 17 entry entry NN cord-277774-kec1o4ys 55 18 and and CC cord-277774-kec1o4ys 55 19 the the DT cord-277774-kec1o4ys 55 20 serine serine NN cord-277774-kec1o4ys 55 21 protease protease NN cord-277774-kec1o4ys 55 22 TMPRSS2 TMPRSS2 NNP cord-277774-kec1o4ys 55 23 for for IN cord-277774-kec1o4ys 55 24 spike spike NN cord-277774-kec1o4ys 55 25 protein protein NN cord-277774-kec1o4ys 55 26 priming prime VBG cord-277774-kec1o4ys 55 27 9 9 CD cord-277774-kec1o4ys 55 28 . . . cord-277774-kec1o4ys 56 1 ACE2 ACE2 NNP cord-277774-kec1o4ys 56 2 , , , cord-277774-kec1o4ys 56 3 a a DT cord-277774-kec1o4ys 56 4 negative negative JJ cord-277774-kec1o4ys 56 5 regulator regulator NN cord-277774-kec1o4ys 56 6 in in IN cord-277774-kec1o4ys 56 7 the the DT cord-277774-kec1o4ys 56 8 renin renin NN cord-277774-kec1o4ys 56 9 - - HYPH cord-277774-kec1o4ys 56 10 angiotensin angiotensin NN cord-277774-kec1o4ys 56 11 system system NN cord-277774-kec1o4ys 56 12 , , , cord-277774-kec1o4ys 56 13 is be VBZ cord-277774-kec1o4ys 56 14 highly highly RB cord-277774-kec1o4ys 56 15 expressed express VBN cord-277774-kec1o4ys 56 16 in in IN cord-277774-kec1o4ys 56 17 the the DT cord-277774-kec1o4ys 56 18 epithelial epithelial JJ cord-277774-kec1o4ys 56 19 cells cell NNS cord-277774-kec1o4ys 56 20 of of IN cord-277774-kec1o4ys 56 21 renal renal JJ cord-277774-kec1o4ys 56 22 tubules tubule NNS cord-277774-kec1o4ys 56 23 , , , cord-277774-kec1o4ys 56 24 seminiferous seminiferous JJ cord-277774-kec1o4ys 56 25 ducts duct NNS cord-277774-kec1o4ys 56 26 of of IN cord-277774-kec1o4ys 56 27 testis testis NN cord-277774-kec1o4ys 56 28 , , , cord-277774-kec1o4ys 56 29 adult adult NN cord-277774-kec1o4ys 56 30 Leydig Leydig NNP cord-277774-kec1o4ys 56 31 cells cell NNS cord-277774-kec1o4ys 56 32 , , , cord-277774-kec1o4ys 56 33 the the DT cord-277774-kec1o4ys 56 34 adrenal adrenal JJ cord-277774-kec1o4ys 56 35 gland gland NN cord-277774-kec1o4ys 56 36 and and CC cord-277774-kec1o4ys 56 37 the the DT cord-277774-kec1o4ys 56 38 prostate prostate NN cord-277774-kec1o4ys 56 39 ( ( -LRB- cord-277774-kec1o4ys 56 40 see see VB cord-277774-kec1o4ys 56 41 Related related JJ cord-277774-kec1o4ys 56 42 links link NNS cord-277774-kec1o4ys 56 43 ) ) -RRB- cord-277774-kec1o4ys 56 44 . . . cord-277774-kec1o4ys 57 1 TMPRSS2 TMPRSS2 NNP cord-277774-kec1o4ys 57 2 is be VBZ cord-277774-kec1o4ys 57 3 highly highly RB cord-277774-kec1o4ys 57 4 expressed express VBN cord-277774-kec1o4ys 57 5 in in IN cord-277774-kec1o4ys 57 6 the the DT cord-277774-kec1o4ys 57 7 kidney kidney NN cord-277774-kec1o4ys 57 8 , , , cord-277774-kec1o4ys 57 9 prostate prostate NN cord-277774-kec1o4ys 57 10 , , , cord-277774-kec1o4ys 57 11 seminal seminal JJ cord-277774-kec1o4ys 57 12 vesicles vesicle NNS cord-277774-kec1o4ys 57 13 and and CC cord-277774-kec1o4ys 57 14 epididymis epididymis NN cord-277774-kec1o4ys 57 15 ( ( -LRB- cord-277774-kec1o4ys 57 16 see see VB cord-277774-kec1o4ys 57 17 Related related JJ cord-277774-kec1o4ys 57 18 links link NNS cord-277774-kec1o4ys 57 19 ) ) -RRB- cord-277774-kec1o4ys 57 20 . . . cord-277774-kec1o4ys 58 1 Both both DT cord-277774-kec1o4ys 58 2 of of IN cord-277774-kec1o4ys 58 3 the the DT cord-277774-kec1o4ys 58 4 key key JJ cord-277774-kec1o4ys 58 5 factors factor NNS cord-277774-kec1o4ys 58 6 that that WDT cord-277774-kec1o4ys 58 7 mediate mediate VBP cord-277774-kec1o4ys 58 8 SARS SARS NNP cord-277774-kec1o4ys 58 9 - - HYPH cord-277774-kec1o4ys 58 10 CoV-2 CoV-2 NNP cord-277774-kec1o4ys 58 11 pathogenicity pathogenicity NN cord-277774-kec1o4ys 58 12 are be VBP cord-277774-kec1o4ys 58 13 highly highly RB cord-277774-kec1o4ys 58 14 expressed express VBN cord-277774-kec1o4ys 58 15 in in IN cord-277774-kec1o4ys 58 16 urogenital urogenital JJ cord-277774-kec1o4ys 58 17 organs organ NNS cord-277774-kec1o4ys 58 18 , , , cord-277774-kec1o4ys 58 19 suggesting suggest VBG cord-277774-kec1o4ys 58 20 that that IN cord-277774-kec1o4ys 58 21 these these DT cord-277774-kec1o4ys 58 22 organs organ NNS cord-277774-kec1o4ys 58 23 could could MD cord-277774-kec1o4ys 58 24 be be VB cord-277774-kec1o4ys 58 25 susceptible susceptible JJ cord-277774-kec1o4ys 58 26 to to IN cord-277774-kec1o4ys 58 27 damage damage NN cord-277774-kec1o4ys 58 28 by by IN cord-277774-kec1o4ys 58 29 this this DT cord-277774-kec1o4ys 58 30 virus virus NN cord-277774-kec1o4ys 58 31 . . . cord-277774-kec1o4ys 59 1 In in IN cord-277774-kec1o4ys 59 2 attempting attempt VBG cord-277774-kec1o4ys 59 3 to to TO cord-277774-kec1o4ys 59 4 contain contain VB cord-277774-kec1o4ys 59 5 viral viral JJ cord-277774-kec1o4ys 59 6 infections infection NNS cord-277774-kec1o4ys 59 7 , , , cord-277774-kec1o4ys 59 8 adaptive adaptive JJ cord-277774-kec1o4ys 59 9 immune immune JJ cord-277774-kec1o4ys 59 10 cells cell NNS cord-277774-kec1o4ys 59 11 can can MD cord-277774-kec1o4ys 59 12 directly directly RB cord-277774-kec1o4ys 59 13 or or CC cord-277774-kec1o4ys 59 14 indirectly indirectly RB cord-277774-kec1o4ys 59 15 target target VB cord-277774-kec1o4ys 59 16 renal renal JJ cord-277774-kec1o4ys 59 17 parenchymal parenchymal NN cord-277774-kec1o4ys 59 18 cells cell NNS cord-277774-kec1o4ys 59 19 to to TO cord-277774-kec1o4ys 59 20 promote promote VB cord-277774-kec1o4ys 59 21 injury injury NN cord-277774-kec1o4ys 59 22 to to IN cord-277774-kec1o4ys 59 23 the the DT cord-277774-kec1o4ys 59 24 kidney kidney NN cord-277774-kec1o4ys 59 25 and and CC cord-277774-kec1o4ys 59 26 loss loss NN cord-277774-kec1o4ys 59 27 of of IN cord-277774-kec1o4ys 59 28 function function NN cord-277774-kec1o4ys 59 29 7 7 CD cord-277774-kec1o4ys 59 30 . . . cord-277774-kec1o4ys 60 1 The the DT cord-277774-kec1o4ys 60 2 testis testis NN cord-277774-kec1o4ys 60 3 , , , cord-277774-kec1o4ys 60 4 in in IN cord-277774-kec1o4ys 60 5 spite spite NN cord-277774-kec1o4ys 60 6 of of IN cord-277774-kec1o4ys 60 7 its -PRON- PRP$ cord-277774-kec1o4ys 60 8 immune immune JJ cord-277774-kec1o4ys 60 9 privileged privileged JJ cord-277774-kec1o4ys 60 10 status status NN cord-277774-kec1o4ys 60 11 , , , cord-277774-kec1o4ys 60 12 can can MD cord-277774-kec1o4ys 60 13 not not RB cord-277774-kec1o4ys 60 14 be be VB cord-277774-kec1o4ys 60 15 isolated isolate VBN cord-277774-kec1o4ys 60 16 from from IN cord-277774-kec1o4ys 60 17 the the DT cord-277774-kec1o4ys 60 18 immune immune JJ cord-277774-kec1o4ys 60 19 system system NN cord-277774-kec1o4ys 60 20 . . . cord-277774-kec1o4ys 61 1 the the DT cord-277774-kec1o4ys 61 2 key key JJ cord-277774-kec1o4ys 61 3 factors factor NNS cord-277774-kec1o4ys 61 4 that that WDT cord-277774-kec1o4ys 61 5 mediate mediate VBP cord-277774-kec1o4ys 61 6 SARS SARS NNP cord-277774-kec1o4ys 61 7 - - HYPH cord-277774-kec1o4ys 61 8 CoV-2 CoV-2 NNP cord-277774-kec1o4ys 61 9 pathogenicity pathogenicity NN cord-277774-kec1o4ys 61 10 are be VBP cord-277774-kec1o4ys 61 11 highly highly RB cord-277774-kec1o4ys 61 12 expressed express VBN cord-277774-kec1o4ys 61 13 in in IN cord-277774-kec1o4ys 61 14 urogenital urogenital JJ cord-277774-kec1o4ys 61 15 organs organ NNS cord-277774-kec1o4ys 61 16 Leukocyte Leukocyte NNP cord-277774-kec1o4ys 61 17 infiltration infiltration NN cord-277774-kec1o4ys 61 18 and and CC cord-277774-kec1o4ys 61 19 CD3 cd3 NN cord-277774-kec1o4ys 61 20 + + CC cord-277774-kec1o4ys 61 21 T T NNP cord-277774-kec1o4ys 61 22 lymphocytes lymphocyte NNS cord-277774-kec1o4ys 61 23 and and CC cord-277774-kec1o4ys 61 24 CD68 CD68 NNS cord-277774-kec1o4ys 61 25 + + CC cord-277774-kec1o4ys 61 26 macrophages macrophage NNS cord-277774-kec1o4ys 61 27 in in IN cord-277774-kec1o4ys 61 28 the the DT cord-277774-kec1o4ys 61 29 interstitial interstitial JJ cord-277774-kec1o4ys 61 30 tissue tissue NN cord-277774-kec1o4ys 61 31 of of IN cord-277774-kec1o4ys 61 32 the the DT cord-277774-kec1o4ys 61 33 testes testis NNS cord-277774-kec1o4ys 61 34 can can MD cord-277774-kec1o4ys 61 35 produce produce VB cord-277774-kec1o4ys 61 36 interferons interferon NNS cord-277774-kec1o4ys 61 37 that that WDT cord-277774-kec1o4ys 61 38 inhibit inhibit VBP cord-277774-kec1o4ys 61 39 steroidogenesis steroidogenesis NN cord-277774-kec1o4ys 61 40 and and CC cord-277774-kec1o4ys 61 41 production production NN cord-277774-kec1o4ys 61 42 of of IN cord-277774-kec1o4ys 61 43 testosterone testosterone NN cord-277774-kec1o4ys 61 44 10 10 CD cord-277774-kec1o4ys 61 45 . . . cord-277774-kec1o4ys 62 1 Inflammatory inflammatory JJ cord-277774-kec1o4ys 62 2 cytokines cytokine NNS cord-277774-kec1o4ys 62 3 that that WDT cord-277774-kec1o4ys 62 4 are be VBP cord-277774-kec1o4ys 62 5 locally locally RB cord-277774-kec1o4ys 62 6 or or CC cord-277774-kec1o4ys 62 7 systematically systematically RB cord-277774-kec1o4ys 62 8 produced produce VBN cord-277774-kec1o4ys 62 9 by by IN cord-277774-kec1o4ys 62 10 these these DT cord-277774-kec1o4ys 62 11 cells cell NNS cord-277774-kec1o4ys 62 12 can can MD cord-277774-kec1o4ys 62 13 activate activate VB cord-277774-kec1o4ys 62 14 the the DT cord-277774-kec1o4ys 62 15 autoimmune autoimmune JJ cord-277774-kec1o4ys 62 16 response response NN cord-277774-kec1o4ys 62 17 , , , cord-277774-kec1o4ys 62 18 destroying destroy VBG cord-277774-kec1o4ys 62 19 the the DT cord-277774-kec1o4ys 62 20 seminiferous seminiferous JJ cord-277774-kec1o4ys 62 21 epithelium epithelium NN cord-277774-kec1o4ys 62 22 , , , cord-277774-kec1o4ys 62 23 which which WDT cord-277774-kec1o4ys 62 24 leads lead VBZ cord-277774-kec1o4ys 62 25 to to IN cord-277774-kec1o4ys 62 26 autoimmune autoimmune JJ cord-277774-kec1o4ys 62 27 orchitis orchitis NNP cord-277774-kec1o4ys 62 28 6 6 CD cord-277774-kec1o4ys 62 29 . . . cord-277774-kec1o4ys 63 1 High high JJ cord-277774-kec1o4ys 63 2 levels level NNS cord-277774-kec1o4ys 63 3 of of IN cord-277774-kec1o4ys 63 4 cytokines cytokine NNS cord-277774-kec1o4ys 63 5 following follow VBG cord-277774-kec1o4ys 63 6 viral viral JJ cord-277774-kec1o4ys 63 7 or or CC cord-277774-kec1o4ys 63 8 bacterial bacterial JJ cord-277774-kec1o4ys 63 9 infection infection NN cord-277774-kec1o4ys 63 10 , , , cord-277774-kec1o4ys 63 11 illness illness NN cord-277774-kec1o4ys 63 12 or or CC cord-277774-kec1o4ys 63 13 injury injury NN cord-277774-kec1o4ys 63 14 can can MD cord-277774-kec1o4ys 63 15 cause cause VB cord-277774-kec1o4ys 63 16 deterioration deterioration NN cord-277774-kec1o4ys 63 17 in in IN cord-277774-kec1o4ys 63 18 spermatogenesis spermatogenesis NN cord-277774-kec1o4ys 63 19 and and CC cord-277774-kec1o4ys 63 20 steroidogenesis steroidogenesis NN cord-277774-kec1o4ys 63 21 , , , cord-277774-kec1o4ys 63 22 adversely adversely RB cord-277774-kec1o4ys 63 23 affecting affect VBG cord-277774-kec1o4ys 63 24 fertility fertility NN cord-277774-kec1o4ys 63 25 10 10 CD cord-277774-kec1o4ys 63 26 . . . cord-277774-kec1o4ys 64 1 Clinical clinical JJ cord-277774-kec1o4ys 64 2 symptoms symptom NNS cord-277774-kec1o4ys 64 3 of of IN cord-277774-kec1o4ys 64 4 COVID-19 covid-19 DT cord-277774-kec1o4ys 64 5 predominantly predominantly RB cord-277774-kec1o4ys 64 6 present present JJ cord-277774-kec1o4ys 64 7 in in IN cord-277774-kec1o4ys 64 8 the the DT cord-277774-kec1o4ys 64 9 respiratory respiratory JJ cord-277774-kec1o4ys 64 10 system system NN cord-277774-kec1o4ys 64 11 , , , cord-277774-kec1o4ys 64 12 but but CC cord-277774-kec1o4ys 64 13 particular particular JJ cord-277774-kec1o4ys 64 14 attention attention NN cord-277774-kec1o4ys 64 15 should should MD cord-277774-kec1o4ys 64 16 be be VB cord-277774-kec1o4ys 64 17 given give VBN cord-277774-kec1o4ys 64 18 to to IN cord-277774-kec1o4ys 64 19 urogenital urogenital JJ cord-277774-kec1o4ys 64 20 manifestations manifestation NNS cord-277774-kec1o4ys 64 21 and/or and/or CC cord-277774-kec1o4ys 64 22 complications complication NNS cord-277774-kec1o4ys 64 23 . . . cord-277774-kec1o4ys 65 1 Older old JJR cord-277774-kec1o4ys 65 2 people people NNS cord-277774-kec1o4ys 65 3 with with IN cord-277774-kec1o4ys 65 4 CKD CKD NNP cord-277774-kec1o4ys 65 5 are be VBP cord-277774-kec1o4ys 65 6 at at IN cord-277774-kec1o4ys 65 7 increased increase VBN cord-277774-kec1o4ys 65 8 risk risk NN cord-277774-kec1o4ys 65 9 of of IN cord-277774-kec1o4ys 65 10 severe severe JJ cord-277774-kec1o4ys 65 11 infection infection NN cord-277774-kec1o4ys 65 12 and and CC cord-277774-kec1o4ys 65 13 AKI AKI NNP cord-277774-kec1o4ys 65 14 is be VBZ cord-277774-kec1o4ys 65 15 associated associate VBN cord-277774-kec1o4ys 65 16 with with IN cord-277774-kec1o4ys 65 17 high high JJ cord-277774-kec1o4ys 65 18 mortality mortality NN cord-277774-kec1o4ys 65 19 . . . cord-277774-kec1o4ys 66 1 Thus thus RB cord-277774-kec1o4ys 66 2 , , , cord-277774-kec1o4ys 66 3 monitoring monitor VBG cord-277774-kec1o4ys 66 4 the the DT cord-277774-kec1o4ys 66 5 kidney kidney NN cord-277774-kec1o4ys 66 6 function function NN cord-277774-kec1o4ys 66 7 of of IN cord-277774-kec1o4ys 66 8 patients patient NNS cord-277774-kec1o4ys 66 9 with with IN cord-277774-kec1o4ys 66 10 severe severe JJ cord-277774-kec1o4ys 66 11 COVID-19 covid-19 NN cord-277774-kec1o4ys 66 12 is be VBZ cord-277774-kec1o4ys 66 13 of of IN cord-277774-kec1o4ys 66 14 great great JJ cord-277774-kec1o4ys 66 15 importance importance NN cord-277774-kec1o4ys 66 16 , , , cord-277774-kec1o4ys 66 17 and and CC cord-277774-kec1o4ys 66 18 CRRT CRRT NNP cord-277774-kec1o4ys 66 19 for for IN cord-277774-kec1o4ys 66 20 protecting protect VBG cord-277774-kec1o4ys 66 21 kidney kidney NN cord-277774-kec1o4ys 66 22 function function NN cord-277774-kec1o4ys 66 23 and and CC cord-277774-kec1o4ys 66 24 cytokine cytokine NN cord-277774-kec1o4ys 66 25 removal removal NN cord-277774-kec1o4ys 66 26 for for IN cord-277774-kec1o4ys 66 27 patients patient NNS cord-277774-kec1o4ys 66 28 who who WP cord-277774-kec1o4ys 66 29 are be VBP cord-277774-kec1o4ys 66 30 critically critically RB cord-277774-kec1o4ys 66 31 ill ill JJ cord-277774-kec1o4ys 66 32 could could MD cord-277774-kec1o4ys 66 33 be be VB cord-277774-kec1o4ys 66 34 crucial crucial JJ cord-277774-kec1o4ys 66 35 to to IN cord-277774-kec1o4ys 66 36 improving improve VBG cord-277774-kec1o4ys 66 37 recovery recovery NN cord-277774-kec1o4ys 66 38 . . . cord-277774-kec1o4ys 67 1 The the DT cord-277774-kec1o4ys 67 2 blood blood NN cord-277774-kec1o4ys 67 3 - - HYPH cord-277774-kec1o4ys 67 4 testis testis NN cord-277774-kec1o4ys 67 5 barrier barrier NN cord-277774-kec1o4ys 67 6 does do VBZ cord-277774-kec1o4ys 67 7 not not RB cord-277774-kec1o4ys 67 8 protect protect VB cord-277774-kec1o4ys 67 9 against against IN cord-277774-kec1o4ys 67 10 COVID-19 covid-19 JJ cord-277774-kec1o4ys 67 11 and and CC cord-277774-kec1o4ys 67 12 abnormal abnormal JJ cord-277774-kec1o4ys 67 13 expression expression NN cord-277774-kec1o4ys 67 14 of of IN cord-277774-kec1o4ys 67 15 sex sex NN cord-277774-kec1o4ys 67 16 hormones hormone NNS cord-277774-kec1o4ys 67 17 could could MD cord-277774-kec1o4ys 67 18 be be VB cord-277774-kec1o4ys 67 19 a a DT cord-277774-kec1o4ys 67 20 result result NN cord-277774-kec1o4ys 67 21 of of IN cord-277774-kec1o4ys 67 22 impaired impaired JJ cord-277774-kec1o4ys 67 23 gonadal gonadal JJ cord-277774-kec1o4ys 67 24 function function NN cord-277774-kec1o4ys 67 25 . . . cord-277774-kec1o4ys 68 1 After after IN cord-277774-kec1o4ys 68 2 recovery recovery NN cord-277774-kec1o4ys 68 3 from from IN cord-277774-kec1o4ys 68 4 COVID-19 covid-19 JJ cord-277774-kec1o4ys 68 5 , , , cord-277774-kec1o4ys 68 6 young young JJ cord-277774-kec1o4ys 68 7 men man NNS cord-277774-kec1o4ys 68 8 who who WP cord-277774-kec1o4ys 68 9 are be VBP cord-277774-kec1o4ys 68 10 interested interested JJ cord-277774-kec1o4ys 68 11 in in IN cord-277774-kec1o4ys 68 12 having have VBG cord-277774-kec1o4ys 68 13 children child NNS cord-277774-kec1o4ys 68 14 should should MD cord-277774-kec1o4ys 68 15 receive receive VB cord-277774-kec1o4ys 68 16 a a DT cord-277774-kec1o4ys 68 17 consultation consultation NN cord-277774-kec1o4ys 68 18 regarding regard VBG cord-277774-kec1o4ys 68 19 their -PRON- PRP$ cord-277774-kec1o4ys 68 20 fertility fertility NN cord-277774-kec1o4ys 68 21 . . . cord-277774-kec1o4ys 69 1 Caution caution NN cord-277774-kec1o4ys 69 2 on on IN cord-277774-kec1o4ys 69 3 kidney kidney NN cord-277774-kec1o4ys 69 4 dysfunctions dysfunction NNS cord-277774-kec1o4ys 69 5 of of IN cord-277774-kec1o4ys 69 6 COVID-19 covid-19 CD cord-277774-kec1o4ys 69 7 patients patient NNS cord-277774-kec1o4ys 69 8 Effect Effect NNP cord-277774-kec1o4ys 69 9 of of IN cord-277774-kec1o4ys 69 10 SARS SARS NNP cord-277774-kec1o4ys 69 11 - - HYPH cord-277774-kec1o4ys 69 12 CoV-2 CoV-2 NNP cord-277774-kec1o4ys 69 13 infection infection NN cord-277774-kec1o4ys 69 14 upon upon IN cord-277774-kec1o4ys 69 15 male male JJ cord-277774-kec1o4ys 69 16 gonadal gonadal JJ cord-277774-kec1o4ys 69 17 function function NN cord-277774-kec1o4ys 69 18 : : : cord-277774-kec1o4ys 69 19 a a DT cord-277774-kec1o4ys 69 20 single single JJ cord-277774-kec1o4ys 69 21 center center NN cord-277774-kec1o4ys 69 22 - - HYPH cord-277774-kec1o4ys 69 23 based base VBN cord-277774-kec1o4ys 69 24 study study NN cord-277774-kec1o4ys 69 25 Acute acute JJ cord-277774-kec1o4ys 69 26 renal renal JJ cord-277774-kec1o4ys 69 27 impairment impairment NN cord-277774-kec1o4ys 69 28 in in IN cord-277774-kec1o4ys 70 1 coronavirus coronavirus NN cord-277774-kec1o4ys 70 2 - - HYPH cord-277774-kec1o4ys 70 3 associated associate VBN cord-277774-kec1o4ys 70 4 severe severe JJ cord-277774-kec1o4ys 70 5 acute acute JJ cord-277774-kec1o4ys 70 6 respiratory respiratory JJ cord-277774-kec1o4ys 70 7 syndrome syndrome NN cord-277774-kec1o4ys 70 8 Histopathology Histopathology NNP cord-277774-kec1o4ys 70 9 of of IN cord-277774-kec1o4ys 70 10 Middle Middle NNP cord-277774-kec1o4ys 70 11 East East NNP cord-277774-kec1o4ys 70 12 respiratory respiratory JJ cord-277774-kec1o4ys 70 13 syndrome syndrome NN cord-277774-kec1o4ys 70 14 coronovirus coronovirus NNP cord-277774-kec1o4ys 70 15 ( ( -LRB- cord-277774-kec1o4ys 70 16 MERS MERS NNP cord-277774-kec1o4ys 70 17 - - HYPH cord-277774-kec1o4ys 70 18 CoV CoV NNP cord-277774-kec1o4ys 70 19 ) ) -RRB- cord-277774-kec1o4ys 70 20 infection infection NN cord-277774-kec1o4ys 70 21 -clinicopathological -clinicopathological JJ cord-277774-kec1o4ys 70 22 and and CC cord-277774-kec1o4ys 70 23 ultrastructural ultrastructural JJ cord-277774-kec1o4ys 70 24 study study NN cord-277774-kec1o4ys 70 25 Clinical clinical JJ cord-277774-kec1o4ys 70 26 outcomes outcome NNS cord-277774-kec1o4ys 70 27 of of IN cord-277774-kec1o4ys 70 28 current current JJ cord-277774-kec1o4ys 70 29 medical medical JJ cord-277774-kec1o4ys 70 30 approaches approach NNS cord-277774-kec1o4ys 70 31 for for IN cord-277774-kec1o4ys 70 32 Middle Middle NNP cord-277774-kec1o4ys 70 33 East East NNP cord-277774-kec1o4ys 70 34 respiratory respiratory JJ cord-277774-kec1o4ys 70 35 syndrome syndrome NN cord-277774-kec1o4ys 70 36 : : : cord-277774-kec1o4ys 70 37 a a DT cord-277774-kec1o4ys 70 38 systematic systematic JJ cord-277774-kec1o4ys 70 39 review review NN cord-277774-kec1o4ys 70 40 and and CC cord-277774-kec1o4ys 70 41 meta meta NNP cord-277774-kec1o4ys 70 42 - - HYPH cord-277774-kec1o4ys 70 43 analysis analysis NN cord-277774-kec1o4ys 70 44 Orchitis Orchitis NNP cord-277774-kec1o4ys 70 45 : : : cord-277774-kec1o4ys 70 46 a a DT cord-277774-kec1o4ys 70 47 complication complication NN cord-277774-kec1o4ys 70 48 of of IN cord-277774-kec1o4ys 70 49 severe severe JJ cord-277774-kec1o4ys 70 50 acute acute JJ cord-277774-kec1o4ys 70 51 respiratory respiratory JJ cord-277774-kec1o4ys 70 52 syndrome syndrome NN cord-277774-kec1o4ys 70 53 ( ( -LRB- cord-277774-kec1o4ys 70 54 SARS SARS NNP cord-277774-kec1o4ys 70 55 ) ) -RRB- cord-277774-kec1o4ys 71 1 Human human JJ cord-277774-kec1o4ys 71 2 kidney kidney NN cord-277774-kec1o4ys 71 3 is be VBZ cord-277774-kec1o4ys 71 4 a a DT cord-277774-kec1o4ys 71 5 target target NN cord-277774-kec1o4ys 71 6 for for IN cord-277774-kec1o4ys 71 7 novel novel JJ cord-277774-kec1o4ys 71 8 severe severe JJ cord-277774-kec1o4ys 71 9 acute acute JJ cord-277774-kec1o4ys 71 10 respiratory respiratory JJ cord-277774-kec1o4ys 71 11 syndrome syndrome NN cord-277774-kec1o4ys 71 12 coronavirus coronavirus NN cord-277774-kec1o4ys 71 13 2 2 CD cord-277774-kec1o4ys 72 1 ( ( -LRB- cord-277774-kec1o4ys 72 2 SARS SARS NNP cord-277774-kec1o4ys 72 3 - - HYPH cord-277774-kec1o4ys 72 4 CoV-2 CoV-2 NNP cord-277774-kec1o4ys 72 5 ) ) -RRB- cord-277774-kec1o4ys 72 6 infection infection NN cord-277774-kec1o4ys 72 7 Clinical clinical JJ cord-277774-kec1o4ys 72 8 pathology pathology NN cord-277774-kec1o4ys 72 9 and and CC cord-277774-kec1o4ys 72 10 pathogenesis pathogenesis NN cord-277774-kec1o4ys 72 11 of of IN cord-277774-kec1o4ys 72 12 severe severe JJ cord-277774-kec1o4ys 72 13 acute acute JJ cord-277774-kec1o4ys 72 14 respiratory respiratory JJ cord-277774-kec1o4ys 72 15 syndrome syndrome NN cord-277774-kec1o4ys 72 16 SARS SARS NNP cord-277774-kec1o4ys 72 17 - - HYPH cord-277774-kec1o4ys 72 18 CoV-2 CoV-2 NNP cord-277774-kec1o4ys 72 19 cell cell NN cord-277774-kec1o4ys 72 20 entry entry NN cord-277774-kec1o4ys 72 21 depends depend VBZ cord-277774-kec1o4ys 72 22 on on IN cord-277774-kec1o4ys 72 23 ACE2 ACE2 NNP cord-277774-kec1o4ys 72 24 and and CC cord-277774-kec1o4ys 72 25 TMPRSS2 TMPRSS2 NNP cord-277774-kec1o4ys 72 26 and and CC cord-277774-kec1o4ys 72 27 is be VBZ cord-277774-kec1o4ys 72 28 blocked block VBN cord-277774-kec1o4ys 72 29 by by IN cord-277774-kec1o4ys 72 30 a a DT cord-277774-kec1o4ys 72 31 clinically clinically RB cord-277774-kec1o4ys 72 32 proven prove VBN cord-277774-kec1o4ys 72 33 protease protease NN cord-277774-kec1o4ys 72 34 inhibitor inhibitor NN cord-277774-kec1o4ys 72 35 Cytokines Cytokines NNPS cord-277774-kec1o4ys 72 36 and and CC cord-277774-kec1o4ys 72 37 the the DT cord-277774-kec1o4ys 72 38 immune immune JJ cord-277774-kec1o4ys 72 39 - - HYPH cord-277774-kec1o4ys 72 40 testicular testicular NN cord-277774-kec1o4ys 72 41 axis axis NN cord-277774-kec1o4ys 72 42 Coronavirus Coronavirus NNP cord-277774-kec1o4ys 72 43 disease disease NN cord-277774-kec1o4ys 72 44 ( ( -LRB- cord-277774-kec1o4ys 72 45 COVID-2019 COVID-2019 NNP cord-277774-kec1o4ys 72 46 ) ) -RRB- cord-277774-kec1o4ys 72 47 situation situation NN cord-277774-kec1o4ys 73 1 reports report NNS cord-277774-kec1o4ys 74 1 Pneumonitis Pneumonitis NNP cord-277774-kec1o4ys 74 2 Diagnosis Diagnosis NNP cord-277774-kec1o4ys 74 3 and and CC cord-277774-kec1o4ys 74 4 Treatment Treatment NNP cord-277774-kec1o4ys 74 5 Program Program NNP cord-277774-kec1o4ys 74 6 for for IN cord-277774-kec1o4ys 74 7 New New NNP cord-277774-kec1o4ys 74 8 Coronavirus Coronavirus NNP cord-277774-kec1o4ys 74 9 Infection infection NN cord-277774-kec1o4ys 75 1 The the DT cord-277774-kec1o4ys 75 2 Cancer Cancer NNP cord-277774-kec1o4ys 75 3 Cell cell NN cord-277774-kec1o4ys 75 4 Line line NN cord-277774-kec1o4ys 75 5 Encyclopedia encyclopedia NN cord-277774-kec1o4ys 75 6 ENSG00000159640-ACE ensg00000159640-ace NN cord-277774-kec1o4ys 76 1 The the DT cord-277774-kec1o4ys 76 2 Human Human NNP cord-277774-kec1o4ys 76 3 Protein Protein NNP cord-277774-kec1o4ys 76 4 Atlas Atlas NNP cord-277774-kec1o4ys 76 5 portal portal NN cord-277774-kec1o4ys 77 1 The the DT cord-277774-kec1o4ys 77 2 authors author NNS cord-277774-kec1o4ys 77 3 declare declare VBP cord-277774-kec1o4ys 77 4 no no DT cord-277774-kec1o4ys 77 5 competing compete VBG cord-277774-kec1o4ys 77 6 interests interest NNS cord-277774-kec1o4ys 77 7 . . .