id sid tid token lemma pos cord-274707-mxh38hwd 1 1 key key NN cord-274707-mxh38hwd 1 2 : : : cord-274707-mxh38hwd 2 1 cord-274707-mxh38hwd cord-274707-mxh38hwd NN cord-274707-mxh38hwd 2 2 authors author NNS cord-274707-mxh38hwd 2 3 : : : cord-274707-mxh38hwd 2 4 Laureano Laureano NNP cord-274707-mxh38hwd 2 5 , , , cord-274707-mxh38hwd 2 6 Ana Ana NNP cord-274707-mxh38hwd 2 7 Flávia Flávia NNP cord-274707-mxh38hwd 2 8 Santarine Santarine NNP cord-274707-mxh38hwd 2 9 ; ; : cord-274707-mxh38hwd 2 10 Riboldi Riboldi NNP cord-274707-mxh38hwd 2 11 , , , cord-274707-mxh38hwd 2 12 Márcia Márcia NNP cord-274707-mxh38hwd 2 13 title title NN cord-274707-mxh38hwd 2 14 : : : cord-274707-mxh38hwd 2 15 The the DT cord-274707-mxh38hwd 2 16 different different JJ cord-274707-mxh38hwd 2 17 tests test NNS cord-274707-mxh38hwd 2 18 for for IN cord-274707-mxh38hwd 2 19 the the DT cord-274707-mxh38hwd 2 20 diagnosis diagnosis NN cord-274707-mxh38hwd 2 21 of of IN cord-274707-mxh38hwd 2 22 COVID-19 covid-19 JJ cord-274707-mxh38hwd 2 23 - - HYPH cord-274707-mxh38hwd 2 24 A a DT cord-274707-mxh38hwd 2 25 review review NN cord-274707-mxh38hwd 2 26 in in IN cord-274707-mxh38hwd 2 27 Brazil Brazil NNP cord-274707-mxh38hwd 2 28 so so RB cord-274707-mxh38hwd 2 29 far far JJ cord-274707-mxh38hwd 2 30 date date NN cord-274707-mxh38hwd 2 31 : : : cord-274707-mxh38hwd 2 32 2020 2020 CD cord-274707-mxh38hwd 2 33 journal journal NN cord-274707-mxh38hwd 2 34 : : : cord-274707-mxh38hwd 2 35 JBRA JBRA NNP cord-274707-mxh38hwd 2 36 Assist Assist NNP cord-274707-mxh38hwd 2 37 Reprod Reprod NNP cord-274707-mxh38hwd 2 38 DOI DOI NNP cord-274707-mxh38hwd 2 39 : : : cord-274707-mxh38hwd 3 1 10.5935/1518 10.5935/1518 CD cord-274707-mxh38hwd 3 2 - - SYM cord-274707-mxh38hwd 3 3 0557.20200046 0557.20200046 CD cord-274707-mxh38hwd 3 4 sha sha NNP cord-274707-mxh38hwd 3 5 : : : cord-274707-mxh38hwd 4 1 e0fac36a1b0ec6d3931da776618343d9c8c5eebb e0fac36a1b0ec6d3931da776618343d9c8c5eebb NN cord-274707-mxh38hwd 5 1 doc_id doc_id CD cord-274707-mxh38hwd 5 2 : : : cord-274707-mxh38hwd 5 3 274707 274707 CD cord-274707-mxh38hwd 5 4 cord_uid cord_uid NNS cord-274707-mxh38hwd 5 5 : : : cord-274707-mxh38hwd 6 1 mxh38hwd mxh38hwd JJ cord-274707-mxh38hwd 6 2 SARS SARS NNP cord-274707-mxh38hwd 6 3 - - HYPH cord-274707-mxh38hwd 6 4 CoV-2 CoV-2 NNP cord-274707-mxh38hwd 6 5 is be VBZ cord-274707-mxh38hwd 6 6 a a DT cord-274707-mxh38hwd 6 7 novel novel JJ cord-274707-mxh38hwd 6 8 virus virus NN cord-274707-mxh38hwd 6 9 from from IN cord-274707-mxh38hwd 6 10 the the DT cord-274707-mxh38hwd 6 11 coronavirus coronavirus NN cord-274707-mxh38hwd 6 12 family family NN cord-274707-mxh38hwd 6 13 that that WDT cord-274707-mxh38hwd 6 14 emerged emerge VBD cord-274707-mxh38hwd 6 15 in in IN cord-274707-mxh38hwd 6 16 the the DT cord-274707-mxh38hwd 6 17 end end NN cord-274707-mxh38hwd 6 18 of of IN cord-274707-mxh38hwd 6 19 December December NNP cord-274707-mxh38hwd 6 20 2019 2019 CD cord-274707-mxh38hwd 6 21 in in IN cord-274707-mxh38hwd 6 22 Wuhan Wuhan NNP cord-274707-mxh38hwd 6 23 , , , cord-274707-mxh38hwd 6 24 China China NNP cord-274707-mxh38hwd 6 25 . . . cord-274707-mxh38hwd 7 1 The the DT cord-274707-mxh38hwd 7 2 virus virus NN cord-274707-mxh38hwd 7 3 is be VBZ cord-274707-mxh38hwd 7 4 now now RB cord-274707-mxh38hwd 7 5 widespread widespread JJ cord-274707-mxh38hwd 7 6 and and CC cord-274707-mxh38hwd 7 7 causing cause VBG cord-274707-mxh38hwd 7 8 the the DT cord-274707-mxh38hwd 7 9 current current JJ cord-274707-mxh38hwd 7 10 pandemic pandemic NN cord-274707-mxh38hwd 7 11 of of IN cord-274707-mxh38hwd 7 12 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 7 13 , , , cord-274707-mxh38hwd 7 14 a a DT cord-274707-mxh38hwd 7 15 highly highly RB cord-274707-mxh38hwd 7 16 pathogenic pathogenic JJ cord-274707-mxh38hwd 7 17 viral viral JJ cord-274707-mxh38hwd 7 18 pneumonia pneumonia NN cord-274707-mxh38hwd 7 19 , , , cord-274707-mxh38hwd 7 20 commonly commonly RB cord-274707-mxh38hwd 7 21 presented present VBN cord-274707-mxh38hwd 7 22 with with IN cord-274707-mxh38hwd 7 23 fever fever NN cord-274707-mxh38hwd 7 24 and and CC cord-274707-mxh38hwd 7 25 cough cough NN cord-274707-mxh38hwd 7 26 , , , cord-274707-mxh38hwd 7 27 which which WDT cord-274707-mxh38hwd 7 28 frequently frequently RB cord-274707-mxh38hwd 7 29 lead lead VBP cord-274707-mxh38hwd 7 30 to to TO cord-274707-mxh38hwd 7 31 lower low JJR cord-274707-mxh38hwd 7 32 respiratory respiratory JJ cord-274707-mxh38hwd 7 33 tract tract NN cord-274707-mxh38hwd 7 34 disease disease NN cord-274707-mxh38hwd 7 35 with with IN cord-274707-mxh38hwd 7 36 poor poor JJ cord-274707-mxh38hwd 7 37 clinical clinical JJ cord-274707-mxh38hwd 7 38 outcomes outcome NNS cord-274707-mxh38hwd 7 39 associated associate VBN cord-274707-mxh38hwd 7 40 with with IN cord-274707-mxh38hwd 7 41 older old JJR cord-274707-mxh38hwd 7 42 age age NN cord-274707-mxh38hwd 7 43 and and CC cord-274707-mxh38hwd 7 44 underlying underlie VBG cord-274707-mxh38hwd 7 45 health health NN cord-274707-mxh38hwd 7 46 conditions condition NNS cord-274707-mxh38hwd 7 47 . . . cord-274707-mxh38hwd 8 1 Supportive supportive JJ cord-274707-mxh38hwd 8 2 care care NN cord-274707-mxh38hwd 8 3 for for IN cord-274707-mxh38hwd 8 4 patients patient NNS cord-274707-mxh38hwd 8 5 is be VBZ cord-274707-mxh38hwd 8 6 typically typically RB cord-274707-mxh38hwd 8 7 the the DT cord-274707-mxh38hwd 8 8 standard standard JJ cord-274707-mxh38hwd 8 9 protocol protocol NN cord-274707-mxh38hwd 8 10 because because IN cord-274707-mxh38hwd 8 11 no no DT cord-274707-mxh38hwd 8 12 specific specific JJ cord-274707-mxh38hwd 8 13 effective effective JJ cord-274707-mxh38hwd 8 14 antiviral antiviral JJ cord-274707-mxh38hwd 8 15 therapies therapy NNS cord-274707-mxh38hwd 8 16 have have VBP cord-274707-mxh38hwd 8 17 been be VBN cord-274707-mxh38hwd 8 18 identified identify VBN cord-274707-mxh38hwd 8 19 so so RB cord-274707-mxh38hwd 8 20 far far RB cord-274707-mxh38hwd 8 21 . . . cord-274707-mxh38hwd 9 1 The the DT cord-274707-mxh38hwd 9 2 current current JJ cord-274707-mxh38hwd 9 3 outbreak outbreak NN cord-274707-mxh38hwd 9 4 is be VBZ cord-274707-mxh38hwd 9 5 challenging challenge VBG cord-274707-mxh38hwd 9 6 governments government NNS cord-274707-mxh38hwd 9 7 and and CC cord-274707-mxh38hwd 9 8 health health NN cord-274707-mxh38hwd 9 9 authorities authority NNS cord-274707-mxh38hwd 9 10 all all RB cord-274707-mxh38hwd 9 11 over over IN cord-274707-mxh38hwd 9 12 the the DT cord-274707-mxh38hwd 9 13 world world NN cord-274707-mxh38hwd 9 14 . . . cord-274707-mxh38hwd 10 1 In in IN cord-274707-mxh38hwd 10 2 here here RB cord-274707-mxh38hwd 10 3 we -PRON- PRP cord-274707-mxh38hwd 10 4 present present VBP cord-274707-mxh38hwd 10 5 a a DT cord-274707-mxh38hwd 10 6 comparison comparison NN cord-274707-mxh38hwd 10 7 among among IN cord-274707-mxh38hwd 10 8 the the DT cord-274707-mxh38hwd 10 9 current current JJ cord-274707-mxh38hwd 10 10 diagnostic diagnostic JJ cord-274707-mxh38hwd 10 11 tools tool NNS cord-274707-mxh38hwd 10 12 and and CC cord-274707-mxh38hwd 10 13 kits kit NNS cord-274707-mxh38hwd 10 14 being be VBG cord-274707-mxh38hwd 10 15 used use VBN cord-274707-mxh38hwd 10 16 to to TO cord-274707-mxh38hwd 10 17 test test VB cord-274707-mxh38hwd 10 18 Brazilian brazilian JJ cord-274707-mxh38hwd 10 19 population population NN cord-274707-mxh38hwd 10 20 . . . cord-274707-mxh38hwd 11 1 The the DT cord-274707-mxh38hwd 11 2 coronavirus coronavirus NN cord-274707-mxh38hwd 11 3 disease disease NN cord-274707-mxh38hwd 11 4 2019 2019 CD cord-274707-mxh38hwd 11 5 ( ( -LRB- cord-274707-mxh38hwd 11 6 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 11 7 ) ) -RRB- cord-274707-mxh38hwd 11 8 epidemic epidemic NN cord-274707-mxh38hwd 11 9 started start VBD cord-274707-mxh38hwd 11 10 in in IN cord-274707-mxh38hwd 11 11 December December NNP cord-274707-mxh38hwd 11 12 2019 2019 CD cord-274707-mxh38hwd 11 13 , , , cord-274707-mxh38hwd 11 14 in in IN cord-274707-mxh38hwd 11 15 Wuhan Wuhan NNP cord-274707-mxh38hwd 11 16 , , , cord-274707-mxh38hwd 11 17 Hubei Hubei NNP cord-274707-mxh38hwd 11 18 province province NN cord-274707-mxh38hwd 11 19 , , , cord-274707-mxh38hwd 11 20 in in IN cord-274707-mxh38hwd 11 21 China China NNP cord-274707-mxh38hwd 11 22 . . . cord-274707-mxh38hwd 12 1 It -PRON- PRP cord-274707-mxh38hwd 12 2 rapidly rapidly RB cord-274707-mxh38hwd 12 3 spread spread VBD cord-274707-mxh38hwd 12 4 across across IN cord-274707-mxh38hwd 12 5 China China NNP cord-274707-mxh38hwd 12 6 and and CC cord-274707-mxh38hwd 12 7 other other JJ cord-274707-mxh38hwd 12 8 countries country NNS cord-274707-mxh38hwd 12 9 , , , cord-274707-mxh38hwd 12 10 raising raise VBG cord-274707-mxh38hwd 12 11 major major JJ cord-274707-mxh38hwd 12 12 global global JJ cord-274707-mxh38hwd 12 13 concerns concern NNS cord-274707-mxh38hwd 12 14 ( ( -LRB- cord-274707-mxh38hwd 12 15 Tang Tang NNP cord-274707-mxh38hwd 12 16 et et FW cord-274707-mxh38hwd 12 17 al al NNP cord-274707-mxh38hwd 12 18 . . NNP cord-274707-mxh38hwd 12 19 , , , cord-274707-mxh38hwd 12 20 2020 2020 CD cord-274707-mxh38hwd 12 21 ) ) -RRB- cord-274707-mxh38hwd 12 22 . . . cord-274707-mxh38hwd 13 1 Its -PRON- PRP$ cord-274707-mxh38hwd 13 2 etiological etiological JJ cord-274707-mxh38hwd 13 3 agent agent NN cord-274707-mxh38hwd 13 4 is be VBZ cord-274707-mxh38hwd 13 5 the the DT cord-274707-mxh38hwd 13 6 SARS SARS NNP cord-274707-mxh38hwd 13 7 - - HYPH cord-274707-mxh38hwd 13 8 CoV-2 CoV-2 NNP cord-274707-mxh38hwd 13 9 also also RB cord-274707-mxh38hwd 13 10 referred refer VBD cord-274707-mxh38hwd 13 11 to to IN cord-274707-mxh38hwd 13 12 as as IN cord-274707-mxh38hwd 13 13 HCoV-19 HCoV-19 NNP cord-274707-mxh38hwd 14 1 ( ( -LRB- cord-274707-mxh38hwd 14 2 Jiang Jiang NNP cord-274707-mxh38hwd 14 3 et et FW cord-274707-mxh38hwd 14 4 al al NNP cord-274707-mxh38hwd 14 5 . . NNP cord-274707-mxh38hwd 14 6 , , , cord-274707-mxh38hwd 14 7 2020 2020 CD cord-274707-mxh38hwd 14 8 ) ) -RRB- cord-274707-mxh38hwd 14 9 . . . cord-274707-mxh38hwd 15 1 According accord VBG cord-274707-mxh38hwd 15 2 to to IN cord-274707-mxh38hwd 15 3 the the DT cord-274707-mxh38hwd 15 4 latest late JJS cord-274707-mxh38hwd 15 5 update update NN cord-274707-mxh38hwd 15 6 by by IN cord-274707-mxh38hwd 15 7 the the DT cord-274707-mxh38hwd 15 8 World World NNP cord-274707-mxh38hwd 15 9 Health Health NNP cord-274707-mxh38hwd 15 10 Organization Organization NNP cord-274707-mxh38hwd 15 11 ( ( -LRB- cord-274707-mxh38hwd 15 12 WHO who WP cord-274707-mxh38hwd 15 13 , , , cord-274707-mxh38hwd 15 14 2020a 2020a CD cord-274707-mxh38hwd 15 15 ) ) -RRB- cord-274707-mxh38hwd 15 16 up up IN cord-274707-mxh38hwd 15 17 to to IN cord-274707-mxh38hwd 15 18 April April NNP cord-274707-mxh38hwd 15 19 28 28 CD cord-274707-mxh38hwd 15 20 , , , cord-274707-mxh38hwd 15 21 2020 2020 CD cord-274707-mxh38hwd 15 22 there there EX cord-274707-mxh38hwd 15 23 were be VBD cord-274707-mxh38hwd 15 24 2,959,929 2,959,929 CD cord-274707-mxh38hwd 15 25 confirmed confirm VBN cord-274707-mxh38hwd 15 26 cases case NNS cord-274707-mxh38hwd 15 27 with with IN cord-274707-mxh38hwd 15 28 202,733 202,733 CD cord-274707-mxh38hwd 15 29 deaths death NNS cord-274707-mxh38hwd 15 30 in in IN cord-274707-mxh38hwd 15 31 213 213 CD cord-274707-mxh38hwd 15 32 countries country NNS cord-274707-mxh38hwd 15 33 , , , cord-274707-mxh38hwd 15 34 areas area NNS cord-274707-mxh38hwd 15 35 or or CC cord-274707-mxh38hwd 15 36 territories territory NNS cord-274707-mxh38hwd 15 37 so so RB cord-274707-mxh38hwd 15 38 far far RB cord-274707-mxh38hwd 15 39 . . . cord-274707-mxh38hwd 16 1 The the DT cord-274707-mxh38hwd 16 2 current current JJ cord-274707-mxh38hwd 16 3 COVID-19 covid-19 JJ cord-274707-mxh38hwd 16 4 outbreak outbreak NN cord-274707-mxh38hwd 16 5 is be VBZ cord-274707-mxh38hwd 16 6 both both CC cord-274707-mxh38hwd 16 7 similar similar JJ cord-274707-mxh38hwd 16 8 and and CC cord-274707-mxh38hwd 16 9 different different JJ cord-274707-mxh38hwd 16 10 to to IN cord-274707-mxh38hwd 16 11 the the DT cord-274707-mxh38hwd 16 12 prior prior JJ cord-274707-mxh38hwd 16 13 SARS SARS NNP cord-274707-mxh38hwd 16 14 ( ( -LRB- cord-274707-mxh38hwd 16 15 2002 2002 CD cord-274707-mxh38hwd 16 16 ) ) -RRB- cord-274707-mxh38hwd 16 17 ( ( -LRB- cord-274707-mxh38hwd 16 18 2003 2003 CD cord-274707-mxh38hwd 16 19 ) ) -RRB- cord-274707-mxh38hwd 16 20 and and CC cord-274707-mxh38hwd 16 21 MERS MERS NNP cord-274707-mxh38hwd 16 22 ( ( -LRB- cord-274707-mxh38hwd 16 23 2012-ongoing 2012-ongoing CD cord-274707-mxh38hwd 16 24 ) ) -RRB- cord-274707-mxh38hwd 16 25 outbreaks outbreak NNS cord-274707-mxh38hwd 16 26 . . . cord-274707-mxh38hwd 17 1 SARS SARS NNP cord-274707-mxh38hwd 17 2 was be VBD cord-274707-mxh38hwd 17 3 initiated initiate VBN cord-274707-mxh38hwd 17 4 by by IN cord-274707-mxh38hwd 17 5 zoonotic zoonotic JJ cord-274707-mxh38hwd 17 6 transmission transmission NN cord-274707-mxh38hwd 17 7 of of IN cord-274707-mxh38hwd 17 8 a a DT cord-274707-mxh38hwd 17 9 novel novel JJ cord-274707-mxh38hwd 17 10 coronavirus coronavirus NN cord-274707-mxh38hwd 17 11 ( ( -LRB- cord-274707-mxh38hwd 17 12 likely likely RB cord-274707-mxh38hwd 17 13 from from IN cord-274707-mxh38hwd 17 14 bats bat NNS cord-274707-mxh38hwd 17 15 via via IN cord-274707-mxh38hwd 17 16 palm palm NN cord-274707-mxh38hwd 17 17 civets civet NNS cord-274707-mxh38hwd 17 18 ) ) -RRB- cord-274707-mxh38hwd 17 19 in in IN cord-274707-mxh38hwd 17 20 markets market NNS cord-274707-mxh38hwd 17 21 in in IN cord-274707-mxh38hwd 17 22 Guangdong Guangdong NNP cord-274707-mxh38hwd 17 23 province province NN cord-274707-mxh38hwd 17 24 , , , cord-274707-mxh38hwd 17 25 China China NNP cord-274707-mxh38hwd 17 26 . . . cord-274707-mxh38hwd 18 1 MERS MERS NNP cord-274707-mxh38hwd 18 2 was be VBD cord-274707-mxh38hwd 18 3 also also RB cord-274707-mxh38hwd 18 4 traced trace VBN cord-274707-mxh38hwd 18 5 to to IN cord-274707-mxh38hwd 18 6 zoonotic zoonotic JJ cord-274707-mxh38hwd 18 7 transmission transmission NN cord-274707-mxh38hwd 18 8 of of IN cord-274707-mxh38hwd 18 9 a a DT cord-274707-mxh38hwd 18 10 novel novel JJ cord-274707-mxh38hwd 18 11 coronavirus coronavirus NN cord-274707-mxh38hwd 18 12 ( ( -LRB- cord-274707-mxh38hwd 18 13 likely likely RB cord-274707-mxh38hwd 18 14 from from IN cord-274707-mxh38hwd 18 15 bats bat NNS cord-274707-mxh38hwd 18 16 via via IN cord-274707-mxh38hwd 18 17 dromedary dromedary NN cord-274707-mxh38hwd 18 18 camels camel NNS cord-274707-mxh38hwd 18 19 ) ) -RRB- cord-274707-mxh38hwd 18 20 in in IN cord-274707-mxh38hwd 18 21 Saudi Saudi NNP cord-274707-mxh38hwd 18 22 Arabia Arabia NNP cord-274707-mxh38hwd 18 23 . . . cord-274707-mxh38hwd 19 1 All all DT cord-274707-mxh38hwd 19 2 three three CD cord-274707-mxh38hwd 19 3 viral viral JJ cord-274707-mxh38hwd 19 4 infections infection NNS cord-274707-mxh38hwd 19 5 commonly commonly RB cord-274707-mxh38hwd 19 6 presented present VBN cord-274707-mxh38hwd 19 7 with with IN cord-274707-mxh38hwd 19 8 fever fever NN cord-274707-mxh38hwd 19 9 and and CC cord-274707-mxh38hwd 19 10 cough cough NN cord-274707-mxh38hwd 19 11 , , , cord-274707-mxh38hwd 19 12 which which WDT cord-274707-mxh38hwd 19 13 frequently frequently RB cord-274707-mxh38hwd 19 14 lead lead VBP cord-274707-mxh38hwd 19 15 to to TO cord-274707-mxh38hwd 19 16 lower low JJR cord-274707-mxh38hwd 19 17 respiratory respiratory JJ cord-274707-mxh38hwd 19 18 tract tract NN cord-274707-mxh38hwd 19 19 disease disease NN cord-274707-mxh38hwd 19 20 with with IN cord-274707-mxh38hwd 19 21 poor poor JJ cord-274707-mxh38hwd 19 22 clinical clinical JJ cord-274707-mxh38hwd 19 23 outcomes outcome NNS cord-274707-mxh38hwd 19 24 associated associate VBN cord-274707-mxh38hwd 19 25 with with IN cord-274707-mxh38hwd 19 26 older old JJR cord-274707-mxh38hwd 19 27 age age NN cord-274707-mxh38hwd 19 28 and and CC cord-274707-mxh38hwd 19 29 underlying underlie VBG cord-274707-mxh38hwd 19 30 health health NN cord-274707-mxh38hwd 19 31 conditions condition NNS cord-274707-mxh38hwd 19 32 ( ( -LRB- cord-274707-mxh38hwd 19 33 Wu Wu NNP cord-274707-mxh38hwd 19 34 & & CC cord-274707-mxh38hwd 19 35 McGoogan McGoogan NNP cord-274707-mxh38hwd 19 36 , , , cord-274707-mxh38hwd 19 37 2020 2020 CD cord-274707-mxh38hwd 19 38 ) ) -RRB- cord-274707-mxh38hwd 19 39 . . . cord-274707-mxh38hwd 20 1 The the DT cord-274707-mxh38hwd 20 2 treatment treatment NN cord-274707-mxh38hwd 20 3 of of IN cord-274707-mxh38hwd 20 4 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 20 5 is be VBZ cord-274707-mxh38hwd 20 6 supportive supportive JJ cord-274707-mxh38hwd 20 7 . . . cord-274707-mxh38hwd 21 1 To to IN cord-274707-mxh38hwd 21 2 date date NN cord-274707-mxh38hwd 21 3 , , , cord-274707-mxh38hwd 21 4 no no DT cord-274707-mxh38hwd 21 5 vaccine vaccine NN cord-274707-mxh38hwd 21 6 , , , cord-274707-mxh38hwd 21 7 antiviral antiviral JJ cord-274707-mxh38hwd 21 8 or or CC cord-274707-mxh38hwd 21 9 other other JJ cord-274707-mxh38hwd 21 10 specific specific JJ cord-274707-mxh38hwd 21 11 treatment treatment NN cord-274707-mxh38hwd 21 12 is be VBZ cord-274707-mxh38hwd 21 13 available available JJ cord-274707-mxh38hwd 21 14 , , , cord-274707-mxh38hwd 21 15 however however RB cord-274707-mxh38hwd 21 16 , , , cord-274707-mxh38hwd 21 17 there there EX cord-274707-mxh38hwd 21 18 are be VBP cord-274707-mxh38hwd 21 19 several several JJ cord-274707-mxh38hwd 21 20 studies study NNS cord-274707-mxh38hwd 21 21 in in IN cord-274707-mxh38hwd 21 22 progress progress NN cord-274707-mxh38hwd 21 23 ( ( -LRB- cord-274707-mxh38hwd 21 24 Wu Wu NNP cord-274707-mxh38hwd 21 25 & & CC cord-274707-mxh38hwd 21 26 Mc Mc NNP cord-274707-mxh38hwd 21 27 - - HYPH cord-274707-mxh38hwd 21 28 Googan Googan NNP cord-274707-mxh38hwd 21 29 , , , cord-274707-mxh38hwd 21 30 2020 2020 CD cord-274707-mxh38hwd 21 31 ) ) -RRB- cord-274707-mxh38hwd 21 32 . . . cord-274707-mxh38hwd 22 1 Also also RB cord-274707-mxh38hwd 22 2 , , , cord-274707-mxh38hwd 22 3 it -PRON- PRP cord-274707-mxh38hwd 22 4 is be VBZ cord-274707-mxh38hwd 22 5 not not RB cord-274707-mxh38hwd 22 6 known know VBN cord-274707-mxh38hwd 22 7 whether whether IN cord-274707-mxh38hwd 22 8 infectiousness infectiousness NN cord-274707-mxh38hwd 22 9 starts start VBZ cord-274707-mxh38hwd 22 10 before before IN cord-274707-mxh38hwd 22 11 onset onset NN cord-274707-mxh38hwd 22 12 of of IN cord-274707-mxh38hwd 22 13 symptoms symptom NNS cord-274707-mxh38hwd 22 14 . . . cord-274707-mxh38hwd 23 1 The the DT cord-274707-mxh38hwd 23 2 incubation incubation NN cord-274707-mxh38hwd 23 3 period period NN cord-274707-mxh38hwd 23 4 for for IN cord-274707-mxh38hwd 23 5 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 23 6 is be VBZ cord-274707-mxh38hwd 23 7 about about RB cord-274707-mxh38hwd 23 8 5 5 CD cord-274707-mxh38hwd 23 9 - - SYM cord-274707-mxh38hwd 23 10 6 6 CD cord-274707-mxh38hwd 23 11 days day NNS cord-274707-mxh38hwd 23 12 ( ( -LRB- cord-274707-mxh38hwd 23 13 Li Li NNP cord-274707-mxh38hwd 23 14 et et NNP cord-274707-mxh38hwd 23 15 al al NNP cord-274707-mxh38hwd 23 16 . . NNP cord-274707-mxh38hwd 23 17 , , , cord-274707-mxh38hwd 23 18 2020a 2020a CD cord-274707-mxh38hwd 23 19 ) ) -RRB- cord-274707-mxh38hwd 23 20 . . . cord-274707-mxh38hwd 24 1 Combining combine VBG cord-274707-mxh38hwd 24 2 this this DT cord-274707-mxh38hwd 24 3 time time NN cord-274707-mxh38hwd 24 4 with with IN cord-274707-mxh38hwd 24 5 a a DT cord-274707-mxh38hwd 24 6 similar similar JJ cord-274707-mxh38hwd 24 7 length length NN cord-274707-mxh38hwd 24 8 serial serial JJ cord-274707-mxh38hwd 24 9 interval interval NN cord-274707-mxh38hwd 24 10 suggests suggest VBZ cord-274707-mxh38hwd 24 11 there there EX cord-274707-mxh38hwd 24 12 might may MD cord-274707-mxh38hwd 24 13 be be VB cord-274707-mxh38hwd 24 14 considerable considerable JJ cord-274707-mxh38hwd 24 15 presymptomatic presymptomatic JJ cord-274707-mxh38hwd 24 16 infectiousness infectiousness NN cord-274707-mxh38hwd 24 17 ( ( -LRB- cord-274707-mxh38hwd 24 18 Anderson Anderson NNP cord-274707-mxh38hwd 24 19 et et NNP cord-274707-mxh38hwd 24 20 al al NNP cord-274707-mxh38hwd 24 21 . . NNP cord-274707-mxh38hwd 24 22 , , , cord-274707-mxh38hwd 24 23 2020 2020 CD cord-274707-mxh38hwd 24 24 ) ) -RRB- cord-274707-mxh38hwd 24 25 . . . cord-274707-mxh38hwd 25 1 So so RB cord-274707-mxh38hwd 25 2 far far RB cord-274707-mxh38hwd 25 3 there there EX cord-274707-mxh38hwd 25 4 have have VBP cord-274707-mxh38hwd 25 5 been be VBN cord-274707-mxh38hwd 25 6 few few JJ cord-274707-mxh38hwd 25 7 clinical clinical JJ cord-274707-mxh38hwd 25 8 studies study NNS cord-274707-mxh38hwd 25 9 to to TO cord-274707-mxh38hwd 25 10 measure measure VB cord-274707-mxh38hwd 25 11 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 25 12 viremia viremia NN cord-274707-mxh38hwd 25 13 and and CC cord-274707-mxh38hwd 25 14 how how WRB cord-274707-mxh38hwd 25 15 it -PRON- PRP cord-274707-mxh38hwd 25 16 changes change VBZ cord-274707-mxh38hwd 25 17 over over IN cord-274707-mxh38hwd 25 18 time time NN cord-274707-mxh38hwd 25 19 in in IN cord-274707-mxh38hwd 25 20 individuals individual NNS cord-274707-mxh38hwd 25 21 ( ( -LRB- cord-274707-mxh38hwd 25 22 Anderson Anderson NNP cord-274707-mxh38hwd 25 23 et et NNP cord-274707-mxh38hwd 25 24 al al NNP cord-274707-mxh38hwd 25 25 . . NNP cord-274707-mxh38hwd 25 26 , , , cord-274707-mxh38hwd 25 27 2020 2020 CD cord-274707-mxh38hwd 25 28 ) ) -RRB- cord-274707-mxh38hwd 25 29 . . . cord-274707-mxh38hwd 26 1 In in IN cord-274707-mxh38hwd 26 2 one one CD cord-274707-mxh38hwd 26 3 study study NN cord-274707-mxh38hwd 26 4 of of IN cord-274707-mxh38hwd 26 5 17 17 CD cord-274707-mxh38hwd 26 6 patients patient NNS cord-274707-mxh38hwd 26 7 diagnosed diagnose VBN cord-274707-mxh38hwd 26 8 with with IN cord-274707-mxh38hwd 26 9 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 26 10 , , , cord-274707-mxh38hwd 26 11 peak peak JJ cord-274707-mxh38hwd 26 12 viremia viremia NN cord-274707-mxh38hwd 26 13 seems seem VBZ cord-274707-mxh38hwd 26 14 to to TO cord-274707-mxh38hwd 26 15 be be VB cord-274707-mxh38hwd 26 16 at at IN cord-274707-mxh38hwd 26 17 the the DT cord-274707-mxh38hwd 26 18 end end NN cord-274707-mxh38hwd 26 19 of of IN cord-274707-mxh38hwd 26 20 the the DT cord-274707-mxh38hwd 26 21 incubation incubation NN cord-274707-mxh38hwd 26 22 period period NN cord-274707-mxh38hwd 26 23 ( ( -LRB- cord-274707-mxh38hwd 26 24 Zou Zou NNP cord-274707-mxh38hwd 26 25 et et FW cord-274707-mxh38hwd 26 26 al al NNP cord-274707-mxh38hwd 26 27 . . NNP cord-274707-mxh38hwd 26 28 , , , cord-274707-mxh38hwd 26 29 2020 2020 CD cord-274707-mxh38hwd 26 30 ) ) -RRB- cord-274707-mxh38hwd 26 31 , , , cord-274707-mxh38hwd 26 32 pointing point VBG cord-274707-mxh38hwd 26 33 to to IN cord-274707-mxh38hwd 26 34 the the DT cord-274707-mxh38hwd 26 35 possibility possibility NN cord-274707-mxh38hwd 26 36 that that IN cord-274707-mxh38hwd 26 37 viremia viremia NN cord-274707-mxh38hwd 26 38 might may MD cord-274707-mxh38hwd 26 39 be be VB cord-274707-mxh38hwd 26 40 high high JJ cord-274707-mxh38hwd 26 41 enough enough RB cord-274707-mxh38hwd 26 42 to to TO cord-274707-mxh38hwd 26 43 trigger trigger VB cord-274707-mxh38hwd 26 44 transmission transmission NN cord-274707-mxh38hwd 26 45 for for IN cord-274707-mxh38hwd 26 46 1 1 CD cord-274707-mxh38hwd 26 47 - - SYM cord-274707-mxh38hwd 26 48 2 2 CD cord-274707-mxh38hwd 26 49 days day NNS cord-274707-mxh38hwd 26 50 before before IN cord-274707-mxh38hwd 26 51 onset onset NN cord-274707-mxh38hwd 26 52 of of IN cord-274707-mxh38hwd 26 53 symptoms symptom NNS cord-274707-mxh38hwd 26 54 . . . cord-274707-mxh38hwd 27 1 Diagnostic diagnostic JJ cord-274707-mxh38hwd 27 2 tests test NNS cord-274707-mxh38hwd 27 3 for for IN cord-274707-mxh38hwd 27 4 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 27 5 have have VBP cord-274707-mxh38hwd 27 6 stood stand VBN cord-274707-mxh38hwd 27 7 out out RP cord-274707-mxh38hwd 27 8 in in IN cord-274707-mxh38hwd 27 9 the the DT cord-274707-mxh38hwd 27 10 current current JJ cord-274707-mxh38hwd 27 11 coronavirus coronavirus NN cord-274707-mxh38hwd 27 12 pandemic pandemic NN cord-274707-mxh38hwd 27 13 as as IN cord-274707-mxh38hwd 27 14 an an DT cord-274707-mxh38hwd 27 15 essential essential JJ cord-274707-mxh38hwd 27 16 tool tool NN cord-274707-mxh38hwd 27 17 for for IN cord-274707-mxh38hwd 27 18 tracking track VBG cord-274707-mxh38hwd 27 19 the the DT cord-274707-mxh38hwd 27 20 spread spread NN cord-274707-mxh38hwd 27 21 of of IN cord-274707-mxh38hwd 27 22 the the DT cord-274707-mxh38hwd 27 23 disease disease NN cord-274707-mxh38hwd 27 24 . . . cord-274707-mxh38hwd 28 1 The the DT cord-274707-mxh38hwd 28 2 genetic genetic JJ cord-274707-mxh38hwd 28 3 sequence sequence NN cord-274707-mxh38hwd 28 4 of of IN cord-274707-mxh38hwd 28 5 the the DT cord-274707-mxh38hwd 28 6 2019 2019 CD cord-274707-mxh38hwd 28 7 novel novel NN cord-274707-mxh38hwd 28 8 coronavirus coronavirus NN cord-274707-mxh38hwd 28 9 enabled enable VBD cord-274707-mxh38hwd 28 10 the the DT cord-274707-mxh38hwd 28 11 rapid rapid JJ cord-274707-mxh38hwd 28 12 development development NN cord-274707-mxh38hwd 28 13 of of IN cord-274707-mxh38hwd 28 14 diagnostics diagnostic NNS cord-274707-mxh38hwd 28 15 tests test NNS cord-274707-mxh38hwd 28 16 specific specific JJ cord-274707-mxh38hwd 28 17 for for IN cord-274707-mxh38hwd 28 18 SARS SARS NNP cord-274707-mxh38hwd 28 19 - - HYPH cord-274707-mxh38hwd 28 20 CoV-2 CoV-2 NNP cord-274707-mxh38hwd 28 21 . . . cord-274707-mxh38hwd 29 1 Since since IN cord-274707-mxh38hwd 29 2 there there EX cord-274707-mxh38hwd 29 3 is be VBZ cord-274707-mxh38hwd 29 4 a a DT cord-274707-mxh38hwd 29 5 wide wide JJ cord-274707-mxh38hwd 29 6 range range NN cord-274707-mxh38hwd 29 7 of of IN cord-274707-mxh38hwd 29 8 diagnostic diagnostic JJ cord-274707-mxh38hwd 29 9 tests test NNS cord-274707-mxh38hwd 29 10 commercially commercially RB cord-274707-mxh38hwd 29 11 available available JJ cord-274707-mxh38hwd 29 12 for for IN cord-274707-mxh38hwd 29 13 SARSCoV-2 sarscov-2 NN cord-274707-mxh38hwd 29 14 , , , cord-274707-mxh38hwd 29 15 in in IN cord-274707-mxh38hwd 29 16 this this DT cord-274707-mxh38hwd 29 17 review review NN cord-274707-mxh38hwd 29 18 we -PRON- PRP cord-274707-mxh38hwd 29 19 present present VBP cord-274707-mxh38hwd 29 20 a a DT cord-274707-mxh38hwd 29 21 comparison comparison NN cord-274707-mxh38hwd 29 22 among among IN cord-274707-mxh38hwd 29 23 of of IN cord-274707-mxh38hwd 29 24 all all PDT cord-274707-mxh38hwd 29 25 them -PRON- PRP cord-274707-mxh38hwd 29 26 and and CC cord-274707-mxh38hwd 29 27 the the DT cord-274707-mxh38hwd 29 28 techniques technique NNS cord-274707-mxh38hwd 29 29 used use VBN cord-274707-mxh38hwd 29 30 to to TO cord-274707-mxh38hwd 29 31 test test VB cord-274707-mxh38hwd 29 32 Brazilian brazilian JJ cord-274707-mxh38hwd 29 33 population population NN cord-274707-mxh38hwd 29 34 . . . cord-274707-mxh38hwd 30 1 JBRA JBRA NNP cord-274707-mxh38hwd 30 2 Assist Assist NNP cord-274707-mxh38hwd 30 3 . . . cord-274707-mxh38hwd 31 1 Reprod Reprod NNP cord-274707-mxh38hwd 31 2 . . . cord-274707-mxh38hwd 32 1 | | NNP cord-274707-mxh38hwd 32 2 v.24 v.24 NNP cord-274707-mxh38hwd 32 3 | | NNP cord-274707-mxh38hwd 33 1 nº3 nº3 NNP cord-274707-mxh38hwd 33 2 | | NNP cord-274707-mxh38hwd 33 3 Apr Apr NNP cord-274707-mxh38hwd 33 4 - - HYPH cord-274707-mxh38hwd 33 5 May May NNP cord-274707-mxh38hwd 33 6 - - HYPH cord-274707-mxh38hwd 33 7 Jun/ Jun/ NNP cord-274707-mxh38hwd 33 8 2020 2020 CD cord-274707-mxh38hwd 34 1 The the DT cord-274707-mxh38hwd 34 2 Brazilian brazilian JJ cord-274707-mxh38hwd 34 3 perspective perspective NN cord-274707-mxh38hwd 34 4 and and CC cord-274707-mxh38hwd 34 5 diagnostic diagnostic JJ cord-274707-mxh38hwd 34 6 tests test NNS cord-274707-mxh38hwd 34 7 available available JJ cord-274707-mxh38hwd 34 8 In in IN cord-274707-mxh38hwd 34 9 Brazil Brazil NNP cord-274707-mxh38hwd 34 10 , , , cord-274707-mxh38hwd 34 11 the the DT cord-274707-mxh38hwd 34 12 first first JJ cord-274707-mxh38hwd 34 13 case case NN cord-274707-mxh38hwd 34 14 of of IN cord-274707-mxh38hwd 34 15 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 34 16 was be VBD cord-274707-mxh38hwd 34 17 confirmed confirm VBN cord-274707-mxh38hwd 34 18 on on IN cord-274707-mxh38hwd 34 19 February February NNP cord-274707-mxh38hwd 34 20 26 26 CD cord-274707-mxh38hwd 34 21 , , , cord-274707-mxh38hwd 34 22 2020 2020 CD cord-274707-mxh38hwd 34 23 by by IN cord-274707-mxh38hwd 34 24 the the DT cord-274707-mxh38hwd 34 25 Ministry Ministry NNP cord-274707-mxh38hwd 34 26 of of IN cord-274707-mxh38hwd 34 27 Health Health NNP cord-274707-mxh38hwd 34 28 . . . cord-274707-mxh38hwd 35 1 A a DT cord-274707-mxh38hwd 35 2 61-yearold 61-yearold CD cord-274707-mxh38hwd 35 3 man man NN cord-274707-mxh38hwd 35 4 was be VBD cord-274707-mxh38hwd 35 5 admitted admit VBN cord-274707-mxh38hwd 35 6 to to IN cord-274707-mxh38hwd 35 7 a a DT cord-274707-mxh38hwd 35 8 private private JJ cord-274707-mxh38hwd 35 9 hospital hospital NN cord-274707-mxh38hwd 35 10 with with IN cord-274707-mxh38hwd 35 11 a a DT cord-274707-mxh38hwd 35 12 history history NN cord-274707-mxh38hwd 35 13 of of IN cord-274707-mxh38hwd 35 14 travel travel NN cord-274707-mxh38hwd 35 15 to to IN cord-274707-mxh38hwd 35 16 Italy Italy NNP cord-274707-mxh38hwd 35 17 , , , cord-274707-mxh38hwd 35 18 but but CC cord-274707-mxh38hwd 35 19 he -PRON- PRP cord-274707-mxh38hwd 35 20 was be VBD cord-274707-mxh38hwd 35 21 already already RB cord-274707-mxh38hwd 35 22 at at IN cord-274707-mxh38hwd 35 23 home home NN cord-274707-mxh38hwd 35 24 when when WRB cord-274707-mxh38hwd 35 25 he -PRON- PRP cord-274707-mxh38hwd 35 26 presented present VBD cord-274707-mxh38hwd 35 27 the the DT cord-274707-mxh38hwd 35 28 symptoms symptom NNS cord-274707-mxh38hwd 35 29 . . . cord-274707-mxh38hwd 36 1 Since since IN cord-274707-mxh38hwd 36 2 then then RB cord-274707-mxh38hwd 36 3 , , , cord-274707-mxh38hwd 36 4 on on IN cord-274707-mxh38hwd 36 5 April April NNP cord-274707-mxh38hwd 36 6 25 25 CD cord-274707-mxh38hwd 36 7 , , , cord-274707-mxh38hwd 36 8 2020 2020 CD cord-274707-mxh38hwd 36 9 , , , cord-274707-mxh38hwd 36 10 58,509 58,509 CD cord-274707-mxh38hwd 36 11 cases case NNS cord-274707-mxh38hwd 36 12 have have VBP cord-274707-mxh38hwd 36 13 been be VBN cord-274707-mxh38hwd 36 14 confirmed confirm VBN cord-274707-mxh38hwd 36 15 , , , cord-274707-mxh38hwd 36 16 most most JJS cord-274707-mxh38hwd 36 17 of of IN cord-274707-mxh38hwd 36 18 them -PRON- PRP cord-274707-mxh38hwd 36 19 in in IN cord-274707-mxh38hwd 36 20 the the DT cord-274707-mxh38hwd 36 21 state state NN cord-274707-mxh38hwd 36 22 of of IN cord-274707-mxh38hwd 36 23 São São NNP cord-274707-mxh38hwd 36 24 Paulo Paulo NNP cord-274707-mxh38hwd 36 25 . . . cord-274707-mxh38hwd 37 1 Figure figure NN cord-274707-mxh38hwd 37 2 1 1 CD cord-274707-mxh38hwd 37 3 illustrates illustrate VBZ cord-274707-mxh38hwd 37 4 the the DT cord-274707-mxh38hwd 37 5 number number NN cord-274707-mxh38hwd 37 6 of of IN cord-274707-mxh38hwd 37 7 cases case NNS cord-274707-mxh38hwd 37 8 per per IN cord-274707-mxh38hwd 37 9 state state NN cord-274707-mxh38hwd 37 10 in in IN cord-274707-mxh38hwd 37 11 Brazil Brazil NNP cord-274707-mxh38hwd 37 12 . . . cord-274707-mxh38hwd 38 1 Brazilian Brazilian NNP cord-274707-mxh38hwd 38 2 Health Health NNP cord-274707-mxh38hwd 38 3 Regulatory Regulatory NNP cord-274707-mxh38hwd 38 4 Agency Agency NNP cord-274707-mxh38hwd 38 5 ( ( -LRB- cord-274707-mxh38hwd 38 6 Anvisa Anvisa NNP cord-274707-mxh38hwd 38 7 ) ) -RRB- cord-274707-mxh38hwd 38 8 published publish VBD cord-274707-mxh38hwd 38 9 the the DT cord-274707-mxh38hwd 38 10 Resolution Resolution NNP cord-274707-mxh38hwd 38 11 ( ( -LRB- cord-274707-mxh38hwd 38 12 RDC RDC NNP cord-274707-mxh38hwd 38 13 348/2020 348/2020 CD cord-274707-mxh38hwd 38 14 ) ) -RRB- cord-274707-mxh38hwd 38 15 , , , cord-274707-mxh38hwd 38 16 which which WDT cord-274707-mxh38hwd 38 17 established establish VBD cord-274707-mxh38hwd 38 18 extraordinary extraordinary JJ cord-274707-mxh38hwd 38 19 and and CC cord-274707-mxh38hwd 38 20 temporary temporary JJ cord-274707-mxh38hwd 38 21 rules rule NNS cord-274707-mxh38hwd 38 22 to to TO cord-274707-mxh38hwd 38 23 speed speed VB cord-274707-mxh38hwd 38 24 up up RP cord-274707-mxh38hwd 38 25 the the DT cord-274707-mxh38hwd 38 26 evaluation evaluation NN cord-274707-mxh38hwd 38 27 of of IN cord-274707-mxh38hwd 38 28 new new JJ cord-274707-mxh38hwd 38 29 products product NNS cord-274707-mxh38hwd 38 30 by by IN cord-274707-mxh38hwd 38 31 prioritizing prioritize VBG cord-274707-mxh38hwd 38 32 the the DT cord-274707-mxh38hwd 38 33 analysis analysis NN cord-274707-mxh38hwd 38 34 of of IN cord-274707-mxh38hwd 38 35 test test NN cord-274707-mxh38hwd 38 36 registration registration NN cord-274707-mxh38hwd 38 37 requests request NNS cord-274707-mxh38hwd 38 38 for for IN cord-274707-mxh38hwd 38 39 detection detection NN cord-274707-mxh38hwd 38 40 of of IN cord-274707-mxh38hwd 38 41 the the DT cord-274707-mxh38hwd 38 42 new new JJ cord-274707-mxh38hwd 38 43 coronavirus coronavirus NN cord-274707-mxh38hwd 38 44 ( ( -LRB- cord-274707-mxh38hwd 38 45 SARSCoV-2 sarscov-2 NN cord-274707-mxh38hwd 38 46 ) ) -RRB- cord-274707-mxh38hwd 38 47 . . . cord-274707-mxh38hwd 39 1 The the DT cord-274707-mxh38hwd 39 2 idea idea NN cord-274707-mxh38hwd 39 3 is be VBZ cord-274707-mxh38hwd 39 4 not not RB cord-274707-mxh38hwd 39 5 to to TO cord-274707-mxh38hwd 39 6 evaluate evaluate VB cord-274707-mxh38hwd 39 7 and and CC cord-274707-mxh38hwd 39 8 approve approve VB cord-274707-mxh38hwd 39 9 products product NNS cord-274707-mxh38hwd 39 10 automatically automatically RB cord-274707-mxh38hwd 39 11 , , , cord-274707-mxh38hwd 39 12 as as IN cord-274707-mxh38hwd 39 13 sanitary sanitary JJ cord-274707-mxh38hwd 39 14 rigor rigor NN cord-274707-mxh38hwd 39 15 must must MD cord-274707-mxh38hwd 39 16 always always RB cord-274707-mxh38hwd 39 17 exist exist VB cord-274707-mxh38hwd 39 18 , , , cord-274707-mxh38hwd 39 19 but but CC cord-274707-mxh38hwd 39 20 rather rather RB cord-274707-mxh38hwd 39 21 to to TO cord-274707-mxh38hwd 39 22 speed speed VB cord-274707-mxh38hwd 39 23 up up RP cord-274707-mxh38hwd 39 24 the the DT cord-274707-mxh38hwd 39 25 process process NN cord-274707-mxh38hwd 39 26 . . . cord-274707-mxh38hwd 40 1 The the DT cord-274707-mxh38hwd 40 2 measure measure NN cord-274707-mxh38hwd 40 3 is be VBZ cord-274707-mxh38hwd 40 4 part part NN cord-274707-mxh38hwd 40 5 of of IN cord-274707-mxh38hwd 40 6 the the DT cord-274707-mxh38hwd 40 7 strategic strategic JJ cord-274707-mxh38hwd 40 8 actions action NNS cord-274707-mxh38hwd 40 9 to to TO cord-274707-mxh38hwd 40 10 enable enable VB cord-274707-mxh38hwd 40 11 products product NNS cord-274707-mxh38hwd 40 12 that that WDT cord-274707-mxh38hwd 40 13 can can MD cord-274707-mxh38hwd 40 14 be be VB cord-274707-mxh38hwd 40 15 used use VBN cord-274707-mxh38hwd 40 16 to to TO cord-274707-mxh38hwd 40 17 face face VB cord-274707-mxh38hwd 40 18 the the DT cord-274707-mxh38hwd 40 19 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 40 20 pandemic pandemic NN cord-274707-mxh38hwd 40 21 . . . cord-274707-mxh38hwd 41 1 Anvisa Anvisa NNP cord-274707-mxh38hwd 41 2 's 's POS cord-274707-mxh38hwd 41 3 role role NN cord-274707-mxh38hwd 41 4 is be VBZ cord-274707-mxh38hwd 41 5 to to TO cord-274707-mxh38hwd 41 6 promote promote VB cord-274707-mxh38hwd 41 7 the the DT cord-274707-mxh38hwd 41 8 protection protection NN cord-274707-mxh38hwd 41 9 of of IN cord-274707-mxh38hwd 41 10 the the DT cord-274707-mxh38hwd 41 11 population population NN cord-274707-mxh38hwd 41 12 's 's POS cord-274707-mxh38hwd 41 13 health health NN cord-274707-mxh38hwd 41 14 by by IN cord-274707-mxh38hwd 41 15 executing execute VBG cord-274707-mxh38hwd 41 16 sanitary sanitary JJ cord-274707-mxh38hwd 41 17 control control NN cord-274707-mxh38hwd 41 18 of of IN cord-274707-mxh38hwd 41 19 the the DT cord-274707-mxh38hwd 41 20 production production NN cord-274707-mxh38hwd 41 21 , , , cord-274707-mxh38hwd 41 22 marketing marketing NN cord-274707-mxh38hwd 41 23 and and CC cord-274707-mxh38hwd 41 24 use use NN cord-274707-mxh38hwd 41 25 of of IN cord-274707-mxh38hwd 41 26 products product NNS cord-274707-mxh38hwd 41 27 and and CC cord-274707-mxh38hwd 41 28 services service NNS cord-274707-mxh38hwd 41 29 subject subject JJ cord-274707-mxh38hwd 41 30 to to IN cord-274707-mxh38hwd 41 31 health health NN cord-274707-mxh38hwd 41 32 regulation regulation NN cord-274707-mxh38hwd 41 33 , , , cord-274707-mxh38hwd 41 34 including include VBG cord-274707-mxh38hwd 41 35 related relate VBN cord-274707-mxh38hwd 41 36 environments environment NNS cord-274707-mxh38hwd 41 37 , , , cord-274707-mxh38hwd 41 38 processes process NNS cord-274707-mxh38hwd 41 39 , , , cord-274707-mxh38hwd 41 40 ingredients ingredient NNS cord-274707-mxh38hwd 41 41 and and CC cord-274707-mxh38hwd 41 42 technologies technology NNS cord-274707-mxh38hwd 41 43 , , , cord-274707-mxh38hwd 41 44 as as RB cord-274707-mxh38hwd 41 45 well well RB cord-274707-mxh38hwd 41 46 as as IN cord-274707-mxh38hwd 41 47 the the DT cord-274707-mxh38hwd 41 48 control control NN cord-274707-mxh38hwd 41 49 in in IN cord-274707-mxh38hwd 41 50 ports port NNS cord-274707-mxh38hwd 41 51 , , , cord-274707-mxh38hwd 41 52 airports airport NNS cord-274707-mxh38hwd 41 53 and and CC cord-274707-mxh38hwd 41 54 borders border NNS cord-274707-mxh38hwd 41 55 . . . cord-274707-mxh38hwd 42 1 On on IN cord-274707-mxh38hwd 42 2 March March NNP cord-274707-mxh38hwd 42 3 19 19 CD cord-274707-mxh38hwd 42 4 , , , cord-274707-mxh38hwd 42 5 the the DT cord-274707-mxh38hwd 42 6 Brazilian Brazilian NNP cord-274707-mxh38hwd 42 7 Health Health NNP cord-274707-mxh38hwd 42 8 Regulatory Regulatory NNP cord-274707-mxh38hwd 42 9 Agency Agency NNP cord-274707-mxh38hwd 42 10 approved approve VBD cord-274707-mxh38hwd 42 11 the the DT cord-274707-mxh38hwd 42 12 first first JJ cord-274707-mxh38hwd 42 13 eight eight CD cord-274707-mxh38hwd 42 14 rapid rapid JJ cord-274707-mxh38hwd 42 15 tests test NNS cord-274707-mxh38hwd 42 16 for for IN cord-274707-mxh38hwd 42 17 the the DT cord-274707-mxh38hwd 42 18 diagnosis diagnosis NN cord-274707-mxh38hwd 42 19 of of IN cord-274707-mxh38hwd 42 20 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 42 21 . . . cord-274707-mxh38hwd 43 1 At at IN cord-274707-mxh38hwd 43 2 the the DT cord-274707-mxh38hwd 43 3 date date NN cord-274707-mxh38hwd 43 4 of of IN cord-274707-mxh38hwd 43 5 the the DT cord-274707-mxh38hwd 43 6 review review NN cord-274707-mxh38hwd 43 7 , , , cord-274707-mxh38hwd 43 8 39 39 CD cord-274707-mxh38hwd 43 9 tests test NNS cord-274707-mxh38hwd 43 10 have have VBP cord-274707-mxh38hwd 43 11 been be VBN cord-274707-mxh38hwd 43 12 approved approve VBN cord-274707-mxh38hwd 43 13 by by IN cord-274707-mxh38hwd 43 14 Anvisa Anvisa NNP cord-274707-mxh38hwd 43 15 so so RB cord-274707-mxh38hwd 43 16 far far RB cord-274707-mxh38hwd 43 17 . . . cord-274707-mxh38hwd 44 1 Of of IN cord-274707-mxh38hwd 44 2 the the DT cord-274707-mxh38hwd 44 3 39 39 CD cord-274707-mxh38hwd 44 4 approved approve VBN cord-274707-mxh38hwd 44 5 , , , cord-274707-mxh38hwd 44 6 21 21 CD cord-274707-mxh38hwd 44 7 are be VBP cord-274707-mxh38hwd 44 8 rapid rapid JJ cord-274707-mxh38hwd 44 9 tests test NNS cord-274707-mxh38hwd 44 10 . . . cord-274707-mxh38hwd 45 1 There there EX cord-274707-mxh38hwd 45 2 are be VBP cord-274707-mxh38hwd 45 3 tests test NNS cord-274707-mxh38hwd 45 4 that that WDT cord-274707-mxh38hwd 45 5 use use VBP cord-274707-mxh38hwd 45 6 blood blood NN cord-274707-mxh38hwd 45 7 , , , cord-274707-mxh38hwd 45 8 serum serum NN cord-274707-mxh38hwd 45 9 or or CC cord-274707-mxh38hwd 45 10 plasma plasma NN cord-274707-mxh38hwd 45 11 and and CC cord-274707-mxh38hwd 45 12 others other NNS cord-274707-mxh38hwd 45 13 that that WDT cord-274707-mxh38hwd 45 14 need need VBP cord-274707-mxh38hwd 45 15 samples sample NNS cord-274707-mxh38hwd 45 16 of of IN cord-274707-mxh38hwd 45 17 secretions secretion NNS cord-274707-mxh38hwd 45 18 collected collect VBN cord-274707-mxh38hwd 45 19 from from IN cord-274707-mxh38hwd 45 20 the the DT cord-274707-mxh38hwd 45 21 airways airway NNS cord-274707-mxh38hwd 45 22 , , , cord-274707-mxh38hwd 45 23 such such JJ cord-274707-mxh38hwd 45 24 as as IN cord-274707-mxh38hwd 45 25 nasopharynx nasopharynx NN cord-274707-mxh38hwd 45 26 ( ( -LRB- cord-274707-mxh38hwd 45 27 nose nose NN cord-274707-mxh38hwd 45 28 ) ) -RRB- cord-274707-mxh38hwd 45 29 and and CC cord-274707-mxh38hwd 45 30 oropharynx oropharynx NN cord-274707-mxh38hwd 45 31 ( ( -LRB- cord-274707-mxh38hwd 45 32 throat throat NN cord-274707-mxh38hwd 45 33 ) ) -RRB- cord-274707-mxh38hwd 45 34 . . . cord-274707-mxh38hwd 46 1 Table table NN cord-274707-mxh38hwd 46 2 1 1 CD cord-274707-mxh38hwd 46 3 and and CC cord-274707-mxh38hwd 46 4 2 2 CD cord-274707-mxh38hwd 46 5 summarizes summarize VBZ cord-274707-mxh38hwd 46 6 all all DT cord-274707-mxh38hwd 46 7 kits kit NNS cord-274707-mxh38hwd 46 8 and and CC cord-274707-mxh38hwd 46 9 tests test NNS cord-274707-mxh38hwd 46 10 registered register VBN cord-274707-mxh38hwd 46 11 in in IN cord-274707-mxh38hwd 46 12 Brazil Brazil NNP cord-274707-mxh38hwd 46 13 . . . cord-274707-mxh38hwd 47 1 Data datum NNS cord-274707-mxh38hwd 47 2 regarding regard VBG cord-274707-mxh38hwd 47 3 accuracy accuracy NN cord-274707-mxh38hwd 47 4 have have VBP cord-274707-mxh38hwd 47 5 been be VBN cord-274707-mxh38hwd 47 6 extracted extract VBN cord-274707-mxh38hwd 47 7 from from IN cord-274707-mxh38hwd 47 8 manual manual JJ cord-274707-mxh38hwd 47 9 instructions instruction NNS cord-274707-mxh38hwd 47 10 available available JJ cord-274707-mxh38hwd 47 11 at at IN cord-274707-mxh38hwd 47 12 Anvisa Anvisa NNP cord-274707-mxh38hwd 47 13 website website NN cord-274707-mxh38hwd 47 14 . . . cord-274707-mxh38hwd 48 1 Most Most JJS cord-274707-mxh38hwd 48 2 rapid rapid JJ cord-274707-mxh38hwd 48 3 tests test NNS cord-274707-mxh38hwd 48 4 use use VBP cord-274707-mxh38hwd 48 5 colloidal colloidal NN cord-274707-mxh38hwd 48 6 gold gold NN cord-274707-mxh38hwd 48 7 particles particle NNS cord-274707-mxh38hwd 48 8 in in IN cord-274707-mxh38hwd 48 9 a a DT cord-274707-mxh38hwd 48 10 technique technique NN cord-274707-mxh38hwd 48 11 known know VBN cord-274707-mxh38hwd 48 12 as as IN cord-274707-mxh38hwd 48 13 immunochromatography immunochromatography NNP cord-274707-mxh38hwd 48 14 , , , cord-274707-mxh38hwd 48 15 also also RB cord-274707-mxh38hwd 48 16 called call VBN cord-274707-mxh38hwd 48 17 lateral lateral JJ cord-274707-mxh38hwd 48 18 flow flow NN cord-274707-mxh38hwd 48 19 immunoassay immunoassay NN cord-274707-mxh38hwd 48 20 , , , cord-274707-mxh38hwd 48 21 a a DT cord-274707-mxh38hwd 48 22 type type NN cord-274707-mxh38hwd 48 23 of of IN cord-274707-mxh38hwd 48 24 sandwich sandwich NN cord-274707-mxh38hwd 48 25 assay assay NN cord-274707-mxh38hwd 48 26 that that WDT cord-274707-mxh38hwd 48 27 relies rely VBZ cord-274707-mxh38hwd 48 28 on on IN cord-274707-mxh38hwd 48 29 a a DT cord-274707-mxh38hwd 48 30 pair pair NN cord-274707-mxh38hwd 48 31 of of IN cord-274707-mxh38hwd 48 32 antibodies antibody NNS cord-274707-mxh38hwd 48 33 used use VBN cord-274707-mxh38hwd 48 34 to to TO cord-274707-mxh38hwd 48 35 recognize recognize VB cord-274707-mxh38hwd 48 36 two two CD cord-274707-mxh38hwd 48 37 independent independent JJ cord-274707-mxh38hwd 48 38 epitopes epitope NNS cord-274707-mxh38hwd 48 39 of of IN cord-274707-mxh38hwd 48 40 a a DT cord-274707-mxh38hwd 48 41 protein protein NN cord-274707-mxh38hwd 48 42 , , , cord-274707-mxh38hwd 48 43 and and CC cord-274707-mxh38hwd 48 44 therefore therefore RB cord-274707-mxh38hwd 48 45 it -PRON- PRP cord-274707-mxh38hwd 48 46 can can MD cord-274707-mxh38hwd 48 47 achieve achieve VB cord-274707-mxh38hwd 48 48 high high JJ cord-274707-mxh38hwd 48 49 specificity specificity NN cord-274707-mxh38hwd 48 50 ( ( -LRB- cord-274707-mxh38hwd 48 51 Zhou Zhou NNP cord-274707-mxh38hwd 48 52 et et NNP cord-274707-mxh38hwd 48 53 al al NNP cord-274707-mxh38hwd 48 54 . . NNP cord-274707-mxh38hwd 48 55 , , , cord-274707-mxh38hwd 48 56 2012 2012 CD cord-274707-mxh38hwd 48 57 ) ) -RRB- cord-274707-mxh38hwd 48 58 . . . cord-274707-mxh38hwd 49 1 Lateral lateral JJ cord-274707-mxh38hwd 49 2 flow flow NN cord-274707-mxh38hwd 49 3 assays assay NNS cord-274707-mxh38hwd 49 4 only only RB cord-274707-mxh38hwd 49 5 require require VBP cord-274707-mxh38hwd 49 6 the the DT cord-274707-mxh38hwd 49 7 application application NN cord-274707-mxh38hwd 49 8 of of IN cord-274707-mxh38hwd 49 9 a a DT cord-274707-mxh38hwd 49 10 sample sample NN cord-274707-mxh38hwd 49 11 ( ( -LRB- cord-274707-mxh38hwd 49 12 sometimes sometimes RB cord-274707-mxh38hwd 49 13 followed follow VBN cord-274707-mxh38hwd 49 14 by by IN cord-274707-mxh38hwd 49 15 the the DT cord-274707-mxh38hwd 49 16 application application NN cord-274707-mxh38hwd 49 17 of of IN cord-274707-mxh38hwd 49 18 a a DT cord-274707-mxh38hwd 49 19 buffer buffer NN cord-274707-mxh38hwd 49 20 solution solution NN cord-274707-mxh38hwd 49 21 ) ) -RRB- cord-274707-mxh38hwd 49 22 and and CC cord-274707-mxh38hwd 49 23 can can MD cord-274707-mxh38hwd 49 24 yield yield VB cord-274707-mxh38hwd 49 25 a a DT cord-274707-mxh38hwd 49 26 result result NN cord-274707-mxh38hwd 49 27 within within IN cord-274707-mxh38hwd 49 28 5 5 CD cord-274707-mxh38hwd 49 29 - - SYM cord-274707-mxh38hwd 49 30 15 15 CD cord-274707-mxh38hwd 49 31 minutes minute NNS cord-274707-mxh38hwd 49 32 ( ( -LRB- cord-274707-mxh38hwd 49 33 O'Farrell O'Farrell NNP cord-274707-mxh38hwd 49 34 , , , cord-274707-mxh38hwd 49 35 2009 2009 CD cord-274707-mxh38hwd 49 36 ) ) -RRB- cord-274707-mxh38hwd 49 37 . . . cord-274707-mxh38hwd 50 1 This this DT cord-274707-mxh38hwd 50 2 kind kind NN cord-274707-mxh38hwd 50 3 of of IN cord-274707-mxh38hwd 50 4 test test NN cord-274707-mxh38hwd 50 5 is be VBZ cord-274707-mxh38hwd 50 6 being be VBG cord-274707-mxh38hwd 50 7 used use VBN cord-274707-mxh38hwd 50 8 for for IN cord-274707-mxh38hwd 50 9 pregnancy pregnancy NN cord-274707-mxh38hwd 50 10 ( ( -LRB- cord-274707-mxh38hwd 50 11 Puertas Puertas NNP cord-274707-mxh38hwd 50 12 et et NNP cord-274707-mxh38hwd 50 13 al al NNP cord-274707-mxh38hwd 50 14 . . NNP cord-274707-mxh38hwd 50 15 , , , cord-274707-mxh38hwd 50 16 2010 2010 CD cord-274707-mxh38hwd 50 17 ) ) -RRB- cord-274707-mxh38hwd 50 18 , , , cord-274707-mxh38hwd 50 19 HIV HIV NNP cord-274707-mxh38hwd 50 20 ( ( -LRB- cord-274707-mxh38hwd 50 21 Granade Granade NNP cord-274707-mxh38hwd 50 22 et et FW cord-274707-mxh38hwd 50 23 al al NNP cord-274707-mxh38hwd 50 24 . . NNP cord-274707-mxh38hwd 50 25 , , , cord-274707-mxh38hwd 50 26 2010 2010 CD cord-274707-mxh38hwd 50 27 ) ) -RRB- cord-274707-mxh38hwd 50 28 , , , cord-274707-mxh38hwd 50 29 bacterial bacterial JJ cord-274707-mxh38hwd 50 30 infections infection NNS cord-274707-mxh38hwd 50 31 ( ( -LRB- cord-274707-mxh38hwd 50 32 Huang Huang NNP cord-274707-mxh38hwd 50 33 , , , cord-274707-mxh38hwd 50 34 2007 2007 CD cord-274707-mxh38hwd 50 35 ) ) -RRB- cord-274707-mxh38hwd 50 36 , , , cord-274707-mxh38hwd 50 37 drugs drug NNS cord-274707-mxh38hwd 50 38 of of IN cord-274707-mxh38hwd 50 39 abuse abuse NN cord-274707-mxh38hwd 50 40 ( ( -LRB- cord-274707-mxh38hwd 50 41 Gonzalez Gonzalez NNP cord-274707-mxh38hwd 50 42 et et NNP cord-274707-mxh38hwd 50 43 al al NNP cord-274707-mxh38hwd 50 44 . . NNP cord-274707-mxh38hwd 50 45 , , , cord-274707-mxh38hwd 50 46 2011 2011 CD cord-274707-mxh38hwd 50 47 ) ) -RRB- cord-274707-mxh38hwd 50 48 , , , cord-274707-mxh38hwd 50 49 food food NN cord-274707-mxh38hwd 50 50 contaminants contaminant NNS cord-274707-mxh38hwd 50 51 and and CC cord-274707-mxh38hwd 50 52 dengue dengue NN cord-274707-mxh38hwd 50 53 virus virus NN cord-274707-mxh38hwd 51 1 ( ( -LRB- cord-274707-mxh38hwd 51 2 Cuzzubbo Cuzzubbo NNP cord-274707-mxh38hwd 51 3 et et NNP cord-274707-mxh38hwd 51 4 al al NNP cord-274707-mxh38hwd 51 5 . . NNP cord-274707-mxh38hwd 51 6 , , , cord-274707-mxh38hwd 51 7 2001 2001 CD cord-274707-mxh38hwd 51 8 ) ) -RRB- cord-274707-mxh38hwd 51 9 , , , cord-274707-mxh38hwd 51 10 and and CC cord-274707-mxh38hwd 51 11 many many JJ cord-274707-mxh38hwd 51 12 tests test NNS cord-274707-mxh38hwd 51 13 are be VBP cord-274707-mxh38hwd 51 14 commercially commercially RB cord-274707-mxh38hwd 51 15 available available JJ cord-274707-mxh38hwd 52 1 ( ( -LRB- cord-274707-mxh38hwd 52 2 Zhou Zhou NNP cord-274707-mxh38hwd 52 3 et et NNP cord-274707-mxh38hwd 52 4 al al NNP cord-274707-mxh38hwd 52 5 . . NNP cord-274707-mxh38hwd 52 6 , , , cord-274707-mxh38hwd 52 7 2012 2012 CD cord-274707-mxh38hwd 52 8 ) ) -RRB- cord-274707-mxh38hwd 52 9 . . . cord-274707-mxh38hwd 53 1 Lateral lateral JJ cord-274707-mxh38hwd 53 2 flow flow NN cord-274707-mxh38hwd 53 3 assays assay NNS cord-274707-mxh38hwd 53 4 are be VBP cord-274707-mxh38hwd 53 5 also also RB cord-274707-mxh38hwd 53 6 being be VBG cord-274707-mxh38hwd 53 7 developed develop VBN cord-274707-mxh38hwd 53 8 for for IN cord-274707-mxh38hwd 53 9 global global JJ cord-274707-mxh38hwd 53 10 health health NN cord-274707-mxh38hwd 53 11 applications application NNS cord-274707-mxh38hwd 53 12 , , , cord-274707-mxh38hwd 53 13 where where WRB cord-274707-mxh38hwd 53 14 devices device NNS cord-274707-mxh38hwd 53 15 that that WDT cord-274707-mxh38hwd 53 16 are be VBP cord-274707-mxh38hwd 53 17 inexpensive inexpensive JJ cord-274707-mxh38hwd 53 18 and and CC cord-274707-mxh38hwd 53 19 easy easy JJ cord-274707-mxh38hwd 53 20 - - HYPH cord-274707-mxh38hwd 53 21 to to IN cord-274707-mxh38hwd 53 22 - - HYPH cord-274707-mxh38hwd 53 23 use use NN cord-274707-mxh38hwd 53 24 are be VBP cord-274707-mxh38hwd 53 25 required require VBN cord-274707-mxh38hwd 53 26 . . . cord-274707-mxh38hwd 54 1 However however RB cord-274707-mxh38hwd 54 2 , , , cord-274707-mxh38hwd 54 3 lateral lateral JJ cord-274707-mxh38hwd 54 4 flow flow NN cord-274707-mxh38hwd 54 5 assays assay NNS cord-274707-mxh38hwd 54 6 are be VBP cord-274707-mxh38hwd 54 7 generally generally RB cord-274707-mxh38hwd 54 8 not not RB cord-274707-mxh38hwd 54 9 quantitative quantitative JJ cord-274707-mxh38hwd 54 10 and and CC cord-274707-mxh38hwd 54 11 often often RB cord-274707-mxh38hwd 54 12 only only RB cord-274707-mxh38hwd 54 13 give give VBP cord-274707-mxh38hwd 54 14 a a DT cord-274707-mxh38hwd 54 15 yes yes UH cord-274707-mxh38hwd 54 16 / / , cord-274707-mxh38hwd 54 17 no no DT cord-274707-mxh38hwd 54 18 answer answer NN cord-274707-mxh38hwd 55 1 ( ( -LRB- cord-274707-mxh38hwd 55 2 Zhou Zhou NNP cord-274707-mxh38hwd 55 3 et et NNP cord-274707-mxh38hwd 55 4 al al NNP cord-274707-mxh38hwd 55 5 . . NNP cord-274707-mxh38hwd 55 6 , , , cord-274707-mxh38hwd 55 7 2012 2012 CD cord-274707-mxh38hwd 55 8 ) ) -RRB- cord-274707-mxh38hwd 55 9 . . . cord-274707-mxh38hwd 56 1 A a DT cord-274707-mxh38hwd 56 2 typical typical JJ cord-274707-mxh38hwd 56 3 immunochromatographic immunochromatographic JJ cord-274707-mxh38hwd 56 4 strip strip NN cord-274707-mxh38hwd 56 5 is be VBZ cord-274707-mxh38hwd 56 6 composed compose VBN cord-274707-mxh38hwd 56 7 by by IN cord-274707-mxh38hwd 56 8 a a DT cord-274707-mxh38hwd 56 9 sample sample NN cord-274707-mxh38hwd 56 10 - - HYPH cord-274707-mxh38hwd 56 11 loading loading NN cord-274707-mxh38hwd 56 12 pad pad NN cord-274707-mxh38hwd 56 13 ( ( -LRB- cord-274707-mxh38hwd 56 14 O'Farrell O'Farrell NNP cord-274707-mxh38hwd 56 15 , , , cord-274707-mxh38hwd 56 16 2009 2009 CD cord-274707-mxh38hwd 56 17 ) ) -RRB- cord-274707-mxh38hwd 56 18 , , , cord-274707-mxh38hwd 56 19 a a DT cord-274707-mxh38hwd 56 20 glass glass NN cord-274707-mxh38hwd 56 21 fibre fibre NN cord-274707-mxh38hwd 56 22 pad pad NN cord-274707-mxh38hwd 56 23 with with IN cord-274707-mxh38hwd 56 24 detection detection NN cord-274707-mxh38hwd 56 25 antibody antibody NN cord-274707-mxh38hwd 56 26 ( ( -LRB- cord-274707-mxh38hwd 56 27 dAb dAb NNP cord-274707-mxh38hwd 56 28 ) ) -RRB- cord-274707-mxh38hwd 56 29 conjugated conjugate VBN cord-274707-mxh38hwd 56 30 to to IN cord-274707-mxh38hwd 56 31 gold gold NN cord-274707-mxh38hwd 56 32 nanoparticles nanoparticle NNS cord-274707-mxh38hwd 56 33 ( ( -LRB- cord-274707-mxh38hwd 56 34 AuNPs AuNPs JJS cord-274707-mxh38hwd 56 35 ) ) -RRB- cord-274707-mxh38hwd 56 36 or or CC cord-274707-mxh38hwd 56 37 latex latex NN cord-274707-mxh38hwd 56 38 beads bead NNS cord-274707-mxh38hwd 56 39 ( ( -LRB- cord-274707-mxh38hwd 56 40 Xu Xu NNP cord-274707-mxh38hwd 56 41 et et NNP cord-274707-mxh38hwd 56 42 al al NNP cord-274707-mxh38hwd 56 43 . . NNP cord-274707-mxh38hwd 56 44 , , , cord-274707-mxh38hwd 56 45 2007 2007 CD cord-274707-mxh38hwd 56 46 ) ) -RRB- cord-274707-mxh38hwd 56 47 , , , cord-274707-mxh38hwd 56 48 a a DT cord-274707-mxh38hwd 56 49 nitrocellulose nitrocellulose NN cord-274707-mxh38hwd 56 50 or or CC cord-274707-mxh38hwd 56 51 polyvinylidene polyvinylidene NN cord-274707-mxh38hwd 56 52 fluoride fluoride NN cord-274707-mxh38hwd 56 53 membrane membrane NN cord-274707-mxh38hwd 56 54 with with IN cord-274707-mxh38hwd 56 55 pre pre JJ cord-274707-mxh38hwd 56 56 - - JJ cord-274707-mxh38hwd 56 57 immobilized immobilize VBN cord-274707-mxh38hwd 56 58 capture capture NN cord-274707-mxh38hwd 56 59 antibody antibody NN cord-274707-mxh38hwd 56 60 ( ( -LRB- cord-274707-mxh38hwd 56 61 cAb cAb NNP cord-274707-mxh38hwd 56 62 ) ) -RRB- cord-274707-mxh38hwd 56 63 , , , cord-274707-mxh38hwd 56 64 a a DT cord-274707-mxh38hwd 56 65 control control NN cord-274707-mxh38hwd 56 66 antibody antibody NN cord-274707-mxh38hwd 56 67 for for IN cord-274707-mxh38hwd 56 68 test test NN cord-274707-mxh38hwd 56 69 validation validation NN cord-274707-mxh38hwd 56 70 ( ( -LRB- cord-274707-mxh38hwd 56 71 Puertas Puertas NNP cord-274707-mxh38hwd 56 72 et et NNP cord-274707-mxh38hwd 56 73 al al NNP cord-274707-mxh38hwd 56 74 . . NNP cord-274707-mxh38hwd 56 75 , , , cord-274707-mxh38hwd 56 76 2010 2010 CD cord-274707-mxh38hwd 56 77 ) ) -RRB- cord-274707-mxh38hwd 56 78 and and CC cord-274707-mxh38hwd 56 79 an an DT cord-274707-mxh38hwd 56 80 absorbent absorbent JJ cord-274707-mxh38hwd 56 81 pad pad NN cord-274707-mxh38hwd 56 82 used use VBN cord-274707-mxh38hwd 56 83 as as IN cord-274707-mxh38hwd 56 84 capillary capillary JJ cord-274707-mxh38hwd 56 85 pump pump NN cord-274707-mxh38hwd 56 86 to to TO cord-274707-mxh38hwd 56 87 draw draw VB cord-274707-mxh38hwd 56 88 the the DT cord-274707-mxh38hwd 56 89 sample sample NN cord-274707-mxh38hwd 56 90 solution solution NN cord-274707-mxh38hwd 56 91 ( ( -LRB- cord-274707-mxh38hwd 56 92 O'Farrell O'Farrell NNP cord-274707-mxh38hwd 56 93 , , , cord-274707-mxh38hwd 56 94 2009 2009 CD cord-274707-mxh38hwd 56 95 ) ) -RRB- cord-274707-mxh38hwd 56 96 . . . cord-274707-mxh38hwd 57 1 To to TO cord-274707-mxh38hwd 57 2 perform perform VB cord-274707-mxh38hwd 57 3 a a DT cord-274707-mxh38hwd 57 4 lateral lateral JJ cord-274707-mxh38hwd 57 5 flow flow NN cord-274707-mxh38hwd 57 6 , , , cord-274707-mxh38hwd 57 7 assay assay VB cord-274707-mxh38hwd 57 8 the the DT cord-274707-mxh38hwd 57 9 sample sample NN cord-274707-mxh38hwd 57 10 containing contain VBG cord-274707-mxh38hwd 57 11 the the DT cord-274707-mxh38hwd 57 12 target target NN cord-274707-mxh38hwd 57 13 analyte analyte NN cord-274707-mxh38hwd 57 14 ( ( -LRB- cord-274707-mxh38hwd 57 15 antigen antigen NNP cord-274707-mxh38hwd 57 16 ) ) -RRB- cord-274707-mxh38hwd 57 17 is be VBZ cord-274707-mxh38hwd 57 18 loaded load VBN cord-274707-mxh38hwd 57 19 on on IN cord-274707-mxh38hwd 57 20 the the DT cord-274707-mxh38hwd 57 21 sample sample NN cord-274707-mxh38hwd 57 22 pad pad NN cord-274707-mxh38hwd 57 23 and and CC cord-274707-mxh38hwd 57 24 flows flow VBZ cord-274707-mxh38hwd 57 25 through through IN cord-274707-mxh38hwd 57 26 the the DT cord-274707-mxh38hwd 57 27 membrane membrane NN cord-274707-mxh38hwd 57 28 by by IN cord-274707-mxh38hwd 57 29 capillary capillary JJ cord-274707-mxh38hwd 57 30 effects effect NNS cord-274707-mxh38hwd 57 31 . . . cord-274707-mxh38hwd 58 1 The the DT cord-274707-mxh38hwd 58 2 liquid liquid NN cord-274707-mxh38hwd 58 3 first first RB cord-274707-mxh38hwd 58 4 dissolves dissolve VBZ cord-274707-mxh38hwd 59 1 the the DT cord-274707-mxh38hwd 59 2 dAb dAb NNP cord-274707-mxh38hwd 59 3 - - HYPH cord-274707-mxh38hwd 59 4 AuNP aunp NN cord-274707-mxh38hwd 59 5 conjugates conjugate NNS cord-274707-mxh38hwd 59 6 and and CC cord-274707-mxh38hwd 59 7 the the DT cord-274707-mxh38hwd 59 8 antigen antigen NN cord-274707-mxh38hwd 59 9 binds bind VBZ cord-274707-mxh38hwd 59 10 to to IN cord-274707-mxh38hwd 59 11 the the DT cord-274707-mxh38hwd 59 12 dAb dAb NNS cord-274707-mxh38hwd 59 13 . . . cord-274707-mxh38hwd 60 1 As as IN cord-274707-mxh38hwd 60 2 the the DT cord-274707-mxh38hwd 60 3 antigen antigen NN cord-274707-mxh38hwd 60 4 - - HYPH cord-274707-mxh38hwd 60 5 dAb dAb NNS cord-274707-mxh38hwd 60 6 pair pair NN cord-274707-mxh38hwd 60 7 flows flow VBZ cord-274707-mxh38hwd 60 8 through through IN cord-274707-mxh38hwd 60 9 the the DT cord-274707-mxh38hwd 60 10 capture capture NN cord-274707-mxh38hwd 60 11 zone zone NN cord-274707-mxh38hwd 60 12 , , , cord-274707-mxh38hwd 60 13 the the DT cord-274707-mxh38hwd 60 14 cAb cab NN cord-274707-mxh38hwd 60 15 will will MD cord-274707-mxh38hwd 60 16 capture capture VB cord-274707-mxh38hwd 60 17 the the DT cord-274707-mxh38hwd 60 18 labelled label VBN cord-274707-mxh38hwd 60 19 antigen antigen NN cord-274707-mxh38hwd 60 20 . . . cord-274707-mxh38hwd 61 1 Further further RB cord-274707-mxh38hwd 61 2 downstream downstream RB cord-274707-mxh38hwd 61 3 , , , cord-274707-mxh38hwd 61 4 the the DT cord-274707-mxh38hwd 61 5 unbound unbound JJ cord-274707-mxh38hwd 61 6 dAb dAb NNS cord-274707-mxh38hwd 61 7 - - HYPH cord-274707-mxh38hwd 61 8 AuNP AuNP NNP cord-274707-mxh38hwd 61 9 reacts react VBZ cord-274707-mxh38hwd 61 10 with with IN cord-274707-mxh38hwd 61 11 the the DT cord-274707-mxh38hwd 61 12 control control NN cord-274707-mxh38hwd 61 13 antibody antibody NN cord-274707-mxh38hwd 61 14 , , , cord-274707-mxh38hwd 61 15 which which WDT cord-274707-mxh38hwd 61 16 binds bind VBZ cord-274707-mxh38hwd 61 17 specifically specifically RB cord-274707-mxh38hwd 61 18 to to IN cord-274707-mxh38hwd 61 19 dAb dAb NNS cord-274707-mxh38hwd 61 20 irrespective irrespective RB cord-274707-mxh38hwd 61 21 of of IN cord-274707-mxh38hwd 61 22 the the DT cord-274707-mxh38hwd 61 23 antigen antigen NN cord-274707-mxh38hwd 61 24 . . . cord-274707-mxh38hwd 62 1 Both both DT cord-274707-mxh38hwd 62 2 the the DT cord-274707-mxh38hwd 62 3 capture capture NN cord-274707-mxh38hwd 62 4 and and CC cord-274707-mxh38hwd 62 5 control control NN cord-274707-mxh38hwd 62 6 lines line NNS cord-274707-mxh38hwd 62 7 may may MD cord-274707-mxh38hwd 62 8 become become VB cord-274707-mxh38hwd 62 9 visible visible JJ cord-274707-mxh38hwd 62 10 due due IN cord-274707-mxh38hwd 62 11 to to IN cord-274707-mxh38hwd 62 12 the the DT cord-274707-mxh38hwd 62 13 accumulation accumulation NN cord-274707-mxh38hwd 62 14 of of IN cord-274707-mxh38hwd 62 15 the the DT cord-274707-mxh38hwd 62 16 AuNPs AuNPs NNP cord-274707-mxh38hwd 62 17 that that WDT cord-274707-mxh38hwd 62 18 produce produce VBP cord-274707-mxh38hwd 62 19 collective collective JJ cord-274707-mxh38hwd 62 20 plasmonic plasmonic JJ cord-274707-mxh38hwd 62 21 effects effect NNS cord-274707-mxh38hwd 62 22 and and CC cord-274707-mxh38hwd 62 23 result result VBP cord-274707-mxh38hwd 62 24 in in IN cord-274707-mxh38hwd 62 25 a a DT cord-274707-mxh38hwd 62 26 red red JJ cord-274707-mxh38hwd 62 27 colour colour NN cord-274707-mxh38hwd 62 28 ( ( -LRB- cord-274707-mxh38hwd 62 29 Xu Xu NNP cord-274707-mxh38hwd 62 30 et et NNP cord-274707-mxh38hwd 62 31 al al NNP cord-274707-mxh38hwd 62 32 . . NNP cord-274707-mxh38hwd 62 33 , , , cord-274707-mxh38hwd 62 34 2007 2007 CD cord-274707-mxh38hwd 62 35 ) ) -RRB- cord-274707-mxh38hwd 62 36 . . . cord-274707-mxh38hwd 63 1 The the DT cord-274707-mxh38hwd 63 2 colour colour NN cord-274707-mxh38hwd 63 3 on on IN cord-274707-mxh38hwd 63 4 the the DT cord-274707-mxh38hwd 63 5 control control NN cord-274707-mxh38hwd 63 6 line line NN cord-274707-mxh38hwd 63 7 indicates indicate VBZ cord-274707-mxh38hwd 63 8 the the DT cord-274707-mxh38hwd 63 9 test test NN cord-274707-mxh38hwd 63 10 is be VBZ cord-274707-mxh38hwd 63 11 valid valid JJ cord-274707-mxh38hwd 63 12 , , , cord-274707-mxh38hwd 63 13 and and CC cord-274707-mxh38hwd 63 14 the the DT cord-274707-mxh38hwd 63 15 colour colour NN cord-274707-mxh38hwd 63 16 on on IN cord-274707-mxh38hwd 63 17 the the DT cord-274707-mxh38hwd 63 18 capture capture NN cord-274707-mxh38hwd 63 19 line line NN cord-274707-mxh38hwd 63 20 suggests suggest VBZ cord-274707-mxh38hwd 63 21 the the DT cord-274707-mxh38hwd 63 22 presence presence NN cord-274707-mxh38hwd 63 23 of of IN cord-274707-mxh38hwd 63 24 target target NN cord-274707-mxh38hwd 63 25 analyte analyte VBN cord-274707-mxh38hwd 63 26 in in IN cord-274707-mxh38hwd 63 27 the the DT cord-274707-mxh38hwd 63 28 sample sample NN cord-274707-mxh38hwd 63 29 solution solution NN cord-274707-mxh38hwd 63 30 ( ( -LRB- cord-274707-mxh38hwd 63 31 Zhou Zhou NNP cord-274707-mxh38hwd 63 32 et et NNP cord-274707-mxh38hwd 63 33 al al NNP cord-274707-mxh38hwd 63 34 . . NNP cord-274707-mxh38hwd 63 35 , , , cord-274707-mxh38hwd 63 36 2012 2012 CD cord-274707-mxh38hwd 63 37 ) ) -RRB- cord-274707-mxh38hwd 63 38 . . . cord-274707-mxh38hwd 64 1 For for IN cord-274707-mxh38hwd 64 2 COVID-19 covid-19 VB cord-274707-mxh38hwd 64 3 the the DT cord-274707-mxh38hwd 64 4 tests test NNS cord-274707-mxh38hwd 64 5 have have VBP cord-274707-mxh38hwd 64 6 been be VBN cord-274707-mxh38hwd 64 7 developed develop VBN cord-274707-mxh38hwd 64 8 with with IN cord-274707-mxh38hwd 64 9 AuNPs AuNPs NNP cord-274707-mxh38hwd 64 10 conjugated conjugate VBN cord-274707-mxh38hwd 64 11 with with IN cord-274707-mxh38hwd 64 12 recombinant recombinant JJ cord-274707-mxh38hwd 64 13 - - HYPH cord-274707-mxh38hwd 64 14 anti anti JJ cord-274707-mxh38hwd 64 15 - - JJ cord-274707-mxh38hwd 64 16 COVID-19 covid-19 JJ cord-274707-mxh38hwd 64 17 antigens antigen NNS cord-274707-mxh38hwd 64 18 . . . cord-274707-mxh38hwd 65 1 The the DT cord-274707-mxh38hwd 65 2 sample sample NN cord-274707-mxh38hwd 65 3 ( ( -LRB- cord-274707-mxh38hwd 65 4 whole whole JJ cord-274707-mxh38hwd 65 5 blood blood NN cord-274707-mxh38hwd 65 6 , , , cord-274707-mxh38hwd 65 7 serum serum NN cord-274707-mxh38hwd 65 8 or or CC cord-274707-mxh38hwd 65 9 plasma plasma NN cord-274707-mxh38hwd 65 10 ) ) -RRB- cord-274707-mxh38hwd 65 11 is be VBZ cord-274707-mxh38hwd 65 12 added add VBN cord-274707-mxh38hwd 65 13 to to IN cord-274707-mxh38hwd 65 14 the the DT cord-274707-mxh38hwd 65 15 pad pad NN cord-274707-mxh38hwd 65 16 and and CC cord-274707-mxh38hwd 65 17 , , , cord-274707-mxh38hwd 65 18 the the DT cord-274707-mxh38hwd 65 19 antibodies antibody NNS cord-274707-mxh38hwd 65 20 against against IN cord-274707-mxh38hwd 65 21 COVID-19 covid-19 CD cord-274707-mxh38hwd 65 22 present present NN cord-274707-mxh38hwd 65 23 in in IN cord-274707-mxh38hwd 65 24 the the DT cord-274707-mxh38hwd 65 25 sample sample NN cord-274707-mxh38hwd 65 26 , , , cord-274707-mxh38hwd 65 27 interact interact VB cord-274707-mxh38hwd 65 28 with with IN cord-274707-mxh38hwd 65 29 the the DT cord-274707-mxh38hwd 65 30 AuNPs AuNPs NNP cord-274707-mxh38hwd 65 31 and and CC cord-274707-mxh38hwd 65 32 run run VB cord-274707-mxh38hwd 65 33 through through IN cord-274707-mxh38hwd 65 34 the the DT cord-274707-mxh38hwd 65 35 membrane membrane NN cord-274707-mxh38hwd 65 36 . . . cord-274707-mxh38hwd 66 1 When when WRB cord-274707-mxh38hwd 66 2 in in IN cord-274707-mxh38hwd 66 3 contact contact NN cord-274707-mxh38hwd 66 4 with with IN cord-274707-mxh38hwd 66 5 the the DT cord-274707-mxh38hwd 66 6 test test NN cord-274707-mxh38hwd 66 7 regions region NNS cord-274707-mxh38hwd 66 8 these these DT cord-274707-mxh38hwd 66 9 gold gold NN cord-274707-mxh38hwd 66 10 - - HYPH cord-274707-mxh38hwd 66 11 antibodies antibody NNS cord-274707-mxh38hwd 66 12 conjugated conjugate VBN cord-274707-mxh38hwd 66 13 are be VBP cord-274707-mxh38hwd 66 14 immobilized immobilize VBN cord-274707-mxh38hwd 66 15 and and CC cord-274707-mxh38hwd 66 16 a a DT cord-274707-mxh38hwd 66 17 colour colour NN cord-274707-mxh38hwd 66 18 line line NN cord-274707-mxh38hwd 66 19 appears appear VBZ cord-274707-mxh38hwd 66 20 on on IN cord-274707-mxh38hwd 66 21 the the DT cord-274707-mxh38hwd 66 22 strip strip NN cord-274707-mxh38hwd 66 23 . . . cord-274707-mxh38hwd 67 1 The the DT cord-274707-mxh38hwd 67 2 presence presence NN cord-274707-mxh38hwd 67 3 of of IN cord-274707-mxh38hwd 67 4 the the DT cord-274707-mxh38hwd 67 5 line line NN cord-274707-mxh38hwd 67 6 indicates indicate VBZ cord-274707-mxh38hwd 67 7 a a DT cord-274707-mxh38hwd 67 8 positive positive JJ cord-274707-mxh38hwd 67 9 result result NN cord-274707-mxh38hwd 67 10 . . . cord-274707-mxh38hwd 68 1 The the DT cord-274707-mxh38hwd 68 2 absence absence NN cord-274707-mxh38hwd 68 3 indicates indicate VBZ cord-274707-mxh38hwd 68 4 a a DT cord-274707-mxh38hwd 68 5 negative negative JJ cord-274707-mxh38hwd 68 6 result result NN cord-274707-mxh38hwd 68 7 . . . cord-274707-mxh38hwd 69 1 There there EX cord-274707-mxh38hwd 69 2 is be VBZ cord-274707-mxh38hwd 69 3 also also RB cord-274707-mxh38hwd 69 4 a a DT cord-274707-mxh38hwd 69 5 control control NN cord-274707-mxh38hwd 69 6 line line NN cord-274707-mxh38hwd 69 7 , , , cord-274707-mxh38hwd 69 8 as as IN cord-274707-mxh38hwd 69 9 an an DT cord-274707-mxh38hwd 69 10 indicative indicative NN cord-274707-mxh38hwd 69 11 that that IN cord-274707-mxh38hwd 69 12 the the DT cord-274707-mxh38hwd 69 13 test test NN cord-274707-mxh38hwd 69 14 is be VBZ cord-274707-mxh38hwd 69 15 valid valid JJ cord-274707-mxh38hwd 69 16 . . . cord-274707-mxh38hwd 70 1 Independent independent JJ cord-274707-mxh38hwd 70 2 on on IN cord-274707-mxh38hwd 70 3 the the DT cord-274707-mxh38hwd 70 4 result result NN cord-274707-mxh38hwd 70 5 the the DT cord-274707-mxh38hwd 70 6 test test NN cord-274707-mxh38hwd 70 7 is be VBZ cord-274707-mxh38hwd 70 8 only only RB cord-274707-mxh38hwd 70 9 valid valid JJ cord-274707-mxh38hwd 70 10 if if IN cord-274707-mxh38hwd 70 11 the the DT cord-274707-mxh38hwd 70 12 control control NN cord-274707-mxh38hwd 70 13 line line NN cord-274707-mxh38hwd 70 14 appears appear VBZ cord-274707-mxh38hwd 70 15 . . . cord-274707-mxh38hwd 71 1 Figure figure NN cord-274707-mxh38hwd 71 2 2 2 CD cord-274707-mxh38hwd 71 3 is be VBZ cord-274707-mxh38hwd 71 4 an an DT cord-274707-mxh38hwd 71 5 example example NN cord-274707-mxh38hwd 71 6 of of IN cord-274707-mxh38hwd 71 7 how how WRB cord-274707-mxh38hwd 71 8 this this DT cord-274707-mxh38hwd 71 9 technology technology NN cord-274707-mxh38hwd 71 10 works work VBZ cord-274707-mxh38hwd 71 11 . . . cord-274707-mxh38hwd 72 1 In in IN cord-274707-mxh38hwd 72 2 this this DT cord-274707-mxh38hwd 72 3 context context NN cord-274707-mxh38hwd 72 4 many many JJ cord-274707-mxh38hwd 72 5 companies company NNS cord-274707-mxh38hwd 72 6 and and CC cord-274707-mxh38hwd 72 7 research research NN cord-274707-mxh38hwd 72 8 groups group NNS cord-274707-mxh38hwd 72 9 developed develop VBD cord-274707-mxh38hwd 72 10 rapid rapid JJ cord-274707-mxh38hwd 72 11 lateral lateral JJ cord-274707-mxh38hwd 72 12 flow flow NN cord-274707-mxh38hwd 72 13 immunoassay immunoassay NN cord-274707-mxh38hwd 72 14 tests test NNS cord-274707-mxh38hwd 72 15 for for IN cord-274707-mxh38hwd 72 16 testing test VBG cord-274707-mxh38hwd 72 17 specific specific JJ cord-274707-mxh38hwd 72 18 antibodies antibody NNS cord-274707-mxh38hwd 72 19 of of IN cord-274707-mxh38hwd 72 20 SARS SARS NNP cord-274707-mxh38hwd 72 21 - - HYPH cord-274707-mxh38hwd 72 22 CoV-2 CoV-2 NNP cord-274707-mxh38hwd 72 23 in in IN cord-274707-mxh38hwd 72 24 patient patient JJ cord-274707-mxh38hwd 72 25 blood blood NN cord-274707-mxh38hwd 72 26 for for IN cord-274707-mxh38hwd 72 27 being be VBG cord-274707-mxh38hwd 72 28 a a DT cord-274707-mxh38hwd 72 29 rapid rapid JJ cord-274707-mxh38hwd 72 30 , , , cord-274707-mxh38hwd 72 31 simple simple JJ cord-274707-mxh38hwd 72 32 , , , cord-274707-mxh38hwd 72 33 highly highly RB cord-274707-mxh38hwd 72 34 sensitive sensitive JJ cord-274707-mxh38hwd 72 35 diagnosis diagnosis NN cord-274707-mxh38hwd 72 36 ( ( -LRB- cord-274707-mxh38hwd 72 37 Li Li NNP cord-274707-mxh38hwd 72 38 et et NNP cord-274707-mxh38hwd 72 39 al al NNP cord-274707-mxh38hwd 72 40 . . NNP cord-274707-mxh38hwd 72 41 , , , cord-274707-mxh38hwd 72 42 2020b 2020b CD cord-274707-mxh38hwd 72 43 ) ) -RRB- cord-274707-mxh38hwd 72 44 . . . cord-274707-mxh38hwd 73 1 One one CD cord-274707-mxh38hwd 73 2 of of IN cord-274707-mxh38hwd 73 3 the the DT cord-274707-mxh38hwd 73 4 first first JJ cord-274707-mxh38hwd 73 5 rapid rapid JJ cord-274707-mxh38hwd 73 6 tests test NNS cord-274707-mxh38hwd 73 7 ( ( -LRB- cord-274707-mxh38hwd 73 8 lateral lateral JJ cord-274707-mxh38hwd 73 9 flow flow NN cord-274707-mxh38hwd 73 10 immunoassay immunoassay NN cord-274707-mxh38hwd 73 11 ) ) -RRB- cord-274707-mxh38hwd 73 12 for for IN cord-274707-mxh38hwd 73 13 SARS SARS NNP cord-274707-mxh38hwd 73 14 - - HYPH cord-274707-mxh38hwd 73 15 CoV-2 CoV-2 NNP cord-274707-mxh38hwd 73 16 IgG igg NN cord-274707-mxh38hwd 73 17 and and CC cord-274707-mxh38hwd 73 18 IgM IgM NNP cord-274707-mxh38hwd 73 19 immune immune JJ cord-274707-mxh38hwd 73 20 responses response NNS cord-274707-mxh38hwd 73 21 was be VBD cord-274707-mxh38hwd 73 22 developed develop VBN cord-274707-mxh38hwd 73 23 by by IN cord-274707-mxh38hwd 73 24 professor´s professor´s NNP cord-274707-mxh38hwd 74 1 Feng Feng NNP cord-274707-mxh38hwd 74 2 Ye Ye NNP cord-274707-mxh38hwd 74 3 group group NN cord-274707-mxh38hwd 74 4 at at IN cord-274707-mxh38hwd 74 5 the the DT cord-274707-mxh38hwd 74 6 National National NNP cord-274707-mxh38hwd 74 7 Clinical Clinical NNP cord-274707-mxh38hwd 74 8 Research Research NNP cord-274707-mxh38hwd 74 9 Centre Centre NNP cord-274707-mxh38hwd 74 10 for for IN cord-274707-mxh38hwd 74 11 Respiratory Respiratory NNP cord-274707-mxh38hwd 74 12 Disease Disease NNP cord-274707-mxh38hwd 74 13 in in IN cord-274707-mxh38hwd 74 14 Guangzhou Guangzhou NNP cord-274707-mxh38hwd 74 15 , , , cord-274707-mxh38hwd 74 16 China China NNP cord-274707-mxh38hwd 74 17 . . . cord-274707-mxh38hwd 75 1 The the DT cord-274707-mxh38hwd 75 2 clinical clinical JJ cord-274707-mxh38hwd 75 3 efficiency efficiency NN cord-274707-mxh38hwd 75 4 of of IN cord-274707-mxh38hwd 75 5 the the DT cord-274707-mxh38hwd 75 6 tests test NNS cord-274707-mxh38hwd 75 7 was be VBD cord-274707-mxh38hwd 75 8 validated validate VBN cord-274707-mxh38hwd 75 9 by by IN cord-274707-mxh38hwd 75 10 collecting collect VBG cord-274707-mxh38hwd 75 11 blood blood NN cord-274707-mxh38hwd 75 12 samples sample NNS cord-274707-mxh38hwd 75 13 from from IN cord-274707-mxh38hwd 75 14 397 397 CD cord-274707-mxh38hwd 75 15 PCR PCR NNP cord-274707-mxh38hwd 75 16 confirmed confirm VBD cord-274707-mxh38hwd 75 17 COVID-19 covid-19 CD cord-274707-mxh38hwd 75 18 patients patient NNS cord-274707-mxh38hwd 75 19 and and CC cord-274707-mxh38hwd 75 20 128 128 CD cord-274707-mxh38hwd 75 21 negative negative JJ cord-274707-mxh38hwd 75 22 patients patient NNS cord-274707-mxh38hwd 75 23 at at IN cord-274707-mxh38hwd 75 24 8 8 CD cord-274707-mxh38hwd 75 25 different different JJ cord-274707-mxh38hwd 75 26 clinical clinical JJ cord-274707-mxh38hwd 75 27 sites site NNS cord-274707-mxh38hwd 75 28 . . . cord-274707-mxh38hwd 76 1 The the DT cord-274707-mxh38hwd 76 2 overall overall JJ cord-274707-mxh38hwd 76 3 testing testing NN cord-274707-mxh38hwd 76 4 sensitivity sensitivity NN cord-274707-mxh38hwd 76 5 was be VBD cord-274707-mxh38hwd 76 6 88.66 88.66 CD cord-274707-mxh38hwd 76 7 % % NN cord-274707-mxh38hwd 76 8 and and CC cord-274707-mxh38hwd 76 9 specificity specificity NN cord-274707-mxh38hwd 76 10 was be VBD cord-274707-mxh38hwd 76 11 90.63 90.63 CD cord-274707-mxh38hwd 76 12 % % NN cord-274707-mxh38hwd 77 1 ( ( -LRB- cord-274707-mxh38hwd 77 2 Li Li NNP cord-274707-mxh38hwd 77 3 et et NNP cord-274707-mxh38hwd 77 4 al al NNP cord-274707-mxh38hwd 77 5 . . NNP cord-274707-mxh38hwd 77 6 , , , cord-274707-mxh38hwd 77 7 2020b 2020b CD cord-274707-mxh38hwd 77 8 ) ) -RRB- cord-274707-mxh38hwd 77 9 . . . cord-274707-mxh38hwd 78 1 This this DT cord-274707-mxh38hwd 78 2 combined combined JJ cord-274707-mxh38hwd 78 3 test test NN cord-274707-mxh38hwd 78 4 is be VBZ cord-274707-mxh38hwd 78 5 being be VBG cord-274707-mxh38hwd 78 6 designed design VBN cord-274707-mxh38hwd 78 7 and and CC cord-274707-mxh38hwd 78 8 manufactured manufacture VBN cord-274707-mxh38hwd 78 9 by by IN cord-274707-mxh38hwd 78 10 Jiangsu Jiangsu NNP cord-274707-mxh38hwd 78 11 Medomics Medomics NNP cord-274707-mxh38hwd 78 12 Medical Medical NNP cord-274707-mxh38hwd 78 13 Technologies Technologies NNP cord-274707-mxh38hwd 78 14 ( ( -LRB- cord-274707-mxh38hwd 78 15 Nanjing Nanjing NNP cord-274707-mxh38hwd 78 16 , , , cord-274707-mxh38hwd 78 17 China China NNP cord-274707-mxh38hwd 78 18 ) ) -RRB- cord-274707-mxh38hwd 78 19 . . . cord-274707-mxh38hwd 79 1 From from IN cord-274707-mxh38hwd 79 2 the the DT cord-274707-mxh38hwd 79 3 39 39 CD cord-274707-mxh38hwd 79 4 tests test NNS cord-274707-mxh38hwd 79 5 approved approve VBD cord-274707-mxh38hwd 79 6 21 21 CD cord-274707-mxh38hwd 79 7 are be VBP cord-274707-mxh38hwd 79 8 immunochromatographic immunochromatographic JJ cord-274707-mxh38hwd 79 9 tests test NNS cord-274707-mxh38hwd 79 10 to to TO cord-274707-mxh38hwd 79 11 evaluate evaluate VB cord-274707-mxh38hwd 79 12 the the DT cord-274707-mxh38hwd 79 13 presence presence NN cord-274707-mxh38hwd 79 14 of of IN cord-274707-mxh38hwd 79 15 IgG IgG NNP cord-274707-mxh38hwd 79 16 and and CC cord-274707-mxh38hwd 79 17 IgM IgM NNP cord-274707-mxh38hwd 79 18 antibodies antibody NNS cord-274707-mxh38hwd 79 19 against against IN cord-274707-mxh38hwd 79 20 SARS SARS NNP cord-274707-mxh38hwd 79 21 - - HYPH cord-274707-mxh38hwd 79 22 CoV-2 CoV-2 NNP cord-274707-mxh38hwd 79 23 . . . cord-274707-mxh38hwd 80 1 Sample sample NN cord-274707-mxh38hwd 80 2 material material NN cord-274707-mxh38hwd 80 3 for for IN cord-274707-mxh38hwd 80 4 those those DT cord-274707-mxh38hwd 80 5 tests test NNS cord-274707-mxh38hwd 80 6 are be VBP cord-274707-mxh38hwd 80 7 whole whole JJ cord-274707-mxh38hwd 80 8 blood blood NN cord-274707-mxh38hwd 80 9 , , , cord-274707-mxh38hwd 80 10 serum serum NN cord-274707-mxh38hwd 80 11 or or CC cord-274707-mxh38hwd 80 12 plasma plasma NN cord-274707-mxh38hwd 80 13 and and CC cord-274707-mxh38hwd 80 14 the the DT cord-274707-mxh38hwd 80 15 time time NN cord-274707-mxh38hwd 80 16 for for IN cord-274707-mxh38hwd 80 17 yielding yield VBG cord-274707-mxh38hwd 80 18 a a DT cord-274707-mxh38hwd 80 19 result result NN cord-274707-mxh38hwd 80 20 varies vary VBZ cord-274707-mxh38hwd 80 21 from from IN cord-274707-mxh38hwd 80 22 10 10 CD cord-274707-mxh38hwd 80 23 - - SYM cord-274707-mxh38hwd 80 24 20 20 CD cord-274707-mxh38hwd 80 25 minutes minute NNS cord-274707-mxh38hwd 80 26 . . . cord-274707-mxh38hwd 81 1 Specificity specificity NN cord-274707-mxh38hwd 81 2 to to IN cord-274707-mxh38hwd 81 3 IgM IgM NNP cord-274707-mxh38hwd 81 4 antibodies antibody NNS cord-274707-mxh38hwd 81 5 was be VBD cord-274707-mxh38hwd 81 6 94 94 CD cord-274707-mxh38hwd 81 7 - - SYM cord-274707-mxh38hwd 81 8 98 98 CD cord-274707-mxh38hwd 81 9 % % NN cord-274707-mxh38hwd 81 10 according accord VBG cord-274707-mxh38hwd 81 11 to to IN cord-274707-mxh38hwd 81 12 the the DT cord-274707-mxh38hwd 81 13 manufacturer manufacturer NN cord-274707-mxh38hwd 81 14 while while IN cord-274707-mxh38hwd 81 15 for for IN cord-274707-mxh38hwd 81 16 the the DT cord-274707-mxh38hwd 81 17 IgG igg NN cord-274707-mxh38hwd 81 18 was be VBD cord-274707-mxh38hwd 81 19 97 97 CD cord-274707-mxh38hwd 81 20 - - SYM cord-274707-mxh38hwd 81 21 98 98 CD cord-274707-mxh38hwd 81 22 % % NN cord-274707-mxh38hwd 81 23 . . . cord-274707-mxh38hwd 82 1 The the DT cord-274707-mxh38hwd 82 2 sensibility sensibility NN cord-274707-mxh38hwd 82 3 for for IN cord-274707-mxh38hwd 82 4 the the DT cord-274707-mxh38hwd 82 5 IgM IgM NNP cord-274707-mxh38hwd 82 6 antibodies antibody NNS cord-274707-mxh38hwd 82 7 was be VBD cord-274707-mxh38hwd 82 8 85 85 CD cord-274707-mxh38hwd 82 9 - - SYM cord-274707-mxh38hwd 82 10 90 90 CD cord-274707-mxh38hwd 82 11 % % NN cord-274707-mxh38hwd 82 12 and and CC cord-274707-mxh38hwd 82 13 for for IN cord-274707-mxh38hwd 82 14 IgG IgG NNP cord-274707-mxh38hwd 82 15 95 95 CD cord-274707-mxh38hwd 82 16 - - SYM cord-274707-mxh38hwd 82 17 100 100 CD cord-274707-mxh38hwd 82 18 % % NN cord-274707-mxh38hwd 82 19 . . . cord-274707-mxh38hwd 83 1 Three three CD cord-274707-mxh38hwd 83 2 tests test NNS cord-274707-mxh38hwd 84 1 -One -One NNP cord-274707-mxh38hwd 85 1 Step Step NNP cord-274707-mxh38hwd 85 2 COVID-2019 COVID-2019 NNP cord-274707-mxh38hwd 85 3 Test Test NNP cord-274707-mxh38hwd 85 4 ( ( -LRB- cord-274707-mxh38hwd 85 5 Celer Celer NNP cord-274707-mxh38hwd 85 6 Biotecnologia Biotecnologia NNP cord-274707-mxh38hwd 85 7 S S NNP cord-274707-mxh38hwd 85 8 / / SYM cord-274707-mxh38hwd 85 9 A a NN cord-274707-mxh38hwd 85 10 ) ) -RRB- cord-274707-mxh38hwd 86 1 , , , cord-274707-mxh38hwd 86 2 CORONAVÍRUS CORONAVÍRUS NNP cord-274707-mxh38hwd 86 3 RAPID rapid JJ cord-274707-mxh38hwd 86 4 TEST TEST NNP cord-274707-mxh38hwd 86 5 ( ( -LRB- cord-274707-mxh38hwd 86 6 Biocon Biocon NNP cord-274707-mxh38hwd 86 7 Diagnósicos Diagnósicos NNP cord-274707-mxh38hwd 86 8 ) ) -RRB- cord-274707-mxh38hwd 86 9 and and CC cord-274707-mxh38hwd 86 10 DPP DPP NNP cord-274707-mxh38hwd 86 11 ® ® . cord-274707-mxh38hwd 87 1 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 87 2 IgM IgM NNP cord-274707-mxh38hwd 87 3 / / SYM cord-274707-mxh38hwd 87 4 IgG IgG NNP cord-274707-mxh38hwd 87 5 System System NNP cord-274707-mxh38hwd 87 6 ( ( -LRB- cord-274707-mxh38hwd 87 7 Orangelife Orangelife NNP cord-274707-mxh38hwd 87 8 ) ) -RRB- cord-274707-mxh38hwd 87 9 had have VBD cord-274707-mxh38hwd 87 10 no no DT cord-274707-mxh38hwd 87 11 available available JJ cord-274707-mxh38hwd 87 12 data datum NNS cord-274707-mxh38hwd 87 13 regarding regard VBG cord-274707-mxh38hwd 87 14 sensibility sensibility NN cord-274707-mxh38hwd 87 15 and and CC cord-274707-mxh38hwd 87 16 specificity specificity NN cord-274707-mxh38hwd 87 17 for for IN cord-274707-mxh38hwd 87 18 IgG igg NN cord-274707-mxh38hwd 87 19 and and CC cord-274707-mxh38hwd 88 1 IgM. IgM. NNP cord-274707-mxh38hwd 89 1 The the DT cord-274707-mxh38hwd 89 2 manufacturers manufacturer NNS cord-274707-mxh38hwd 89 3 of of IN cord-274707-mxh38hwd 89 4 the the DT cord-274707-mxh38hwd 89 5 tests test NNS cord-274707-mxh38hwd 89 6 CORONAVÍRUS CORONAVÍRUS NNP cord-274707-mxh38hwd 89 7 IgG/ igg/ POS cord-274707-mxh38hwd 89 8 IgM IgM NNP cord-274707-mxh38hwd 89 9 ( ( -LRB- cord-274707-mxh38hwd 89 10 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 89 11 ) ) -RRB- cord-274707-mxh38hwd 89 12 and and CC cord-274707-mxh38hwd 89 13 2019-nCoV 2019-ncov CD cord-274707-mxh38hwd 89 14 IgG IgG NNP cord-274707-mxh38hwd 89 15 / / SYM cord-274707-mxh38hwd 89 16 IgM IgM NNP cord-274707-mxh38hwd 89 17 Teste Teste NNP cord-274707-mxh38hwd 89 18 Rápido Rápido NNP cord-274707-mxh38hwd 89 19 em -PRON- NNP cord-274707-mxh38hwd 89 20 Cassete Cassete NNP cord-274707-mxh38hwd 89 21 reported report VBD cord-274707-mxh38hwd 89 22 that that IN cord-274707-mxh38hwd 89 23 hematocrit hematocrit NN cord-274707-mxh38hwd 89 24 levels level NNS cord-274707-mxh38hwd 89 25 may may MD cord-274707-mxh38hwd 89 26 affect affect VB cord-274707-mxh38hwd 89 27 results result NNS cord-274707-mxh38hwd 89 28 . . . cord-274707-mxh38hwd 90 1 The the DT cord-274707-mxh38hwd 90 2 hematocrit hematocrit NN cord-274707-mxh38hwd 90 3 level level NN cord-274707-mxh38hwd 90 4 should should MD cord-274707-mxh38hwd 90 5 be be VB cord-274707-mxh38hwd 90 6 between between IN cord-274707-mxh38hwd 90 7 25 25 CD cord-274707-mxh38hwd 90 8 % % NN cord-274707-mxh38hwd 90 9 -65 -65 CD cord-274707-mxh38hwd 90 10 % % NN cord-274707-mxh38hwd 90 11 to to TO cord-274707-mxh38hwd 90 12 yield yield VB cord-274707-mxh38hwd 90 13 accurate accurate JJ cord-274707-mxh38hwd 90 14 results result NNS cord-274707-mxh38hwd 90 15 . . . cord-274707-mxh38hwd 91 1 The the DT cord-274707-mxh38hwd 91 2 manufacturer manufacturer NN cord-274707-mxh38hwd 91 3 of of IN cord-274707-mxh38hwd 91 4 MedTeste MedTeste NNP cord-274707-mxh38hwd 91 5 Coronavírus Coronavírus NNP cord-274707-mxh38hwd 91 6 ( ( -LRB- cord-274707-mxh38hwd 91 7 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 91 8 ) ) -RRB- cord-274707-mxh38hwd 91 9 IgG IgG NNP cord-274707-mxh38hwd 91 10 / / SYM cord-274707-mxh38hwd 91 11 IgM IgM NNP cord-274707-mxh38hwd 91 12 informed inform VBD cord-274707-mxh38hwd 91 13 that that IN cord-274707-mxh38hwd 91 14 results result NNS cord-274707-mxh38hwd 91 15 of of IN cord-274707-mxh38hwd 91 16 immunocompromised immunocompromised JJ cord-274707-mxh38hwd 91 17 patients patient NNS cord-274707-mxh38hwd 91 18 should should MD cord-274707-mxh38hwd 91 19 be be VB cord-274707-mxh38hwd 91 20 interpreted interpret VBN cord-274707-mxh38hwd 91 21 with with IN cord-274707-mxh38hwd 91 22 caution caution NN cord-274707-mxh38hwd 91 23 . . . cord-274707-mxh38hwd 92 1 The the DT cord-274707-mxh38hwd 92 2 manufacturer manufacturer NN cord-274707-mxh38hwd 92 3 of of IN cord-274707-mxh38hwd 92 4 the the DT cord-274707-mxh38hwd 92 5 test test NN cord-274707-mxh38hwd 92 6 Anti Anti NNP cord-274707-mxh38hwd 92 7 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 92 8 IgG/ igg/ CD cord-274707-mxh38hwd 92 9 IgM IgM NNP cord-274707-mxh38hwd 92 10 Rapid Rapid NNP cord-274707-mxh38hwd 92 11 Test Test NNP cord-274707-mxh38hwd 92 12 declared declare VBD cord-274707-mxh38hwd 92 13 that that IN cord-274707-mxh38hwd 92 14 no no DT cord-274707-mxh38hwd 92 15 false false JJ cord-274707-mxh38hwd 92 16 results result NNS cord-274707-mxh38hwd 92 17 were be VBD cord-274707-mxh38hwd 92 18 observed observe VBN cord-274707-mxh38hwd 92 19 in in IN cord-274707-mxh38hwd 92 20 positive positive JJ cord-274707-mxh38hwd 92 21 sample sample NN cord-274707-mxh38hwd 92 22 for for IN cord-274707-mxh38hwd 92 23 the the DT cord-274707-mxh38hwd 92 24 pathogens pathogen NNS cord-274707-mxh38hwd 92 25 : : : cord-274707-mxh38hwd 92 26 influenza influenza NN cord-274707-mxh38hwd 92 27 A A NNP cord-274707-mxh38hwd 92 28 , , , cord-274707-mxh38hwd 92 29 influenza influenza NN cord-274707-mxh38hwd 92 30 BRSV BRSV NNP cord-274707-mxh38hwd 92 31 , , , cord-274707-mxh38hwd 92 32 adenovirus adenovirus NN cord-274707-mxh38hwd 92 33 , , , cord-274707-mxh38hwd 92 34 HBsAg HBsAg NNP cord-274707-mxh38hwd 92 35 syphilis syphili NNS cord-274707-mxh38hwd 92 36 , , , cord-274707-mxh38hwd 92 37 Helicobacter Helicobacter NNP cord-274707-mxh38hwd 92 38 pylori pylori NN cord-274707-mxh38hwd 92 39 , , , cord-274707-mxh38hwd 92 40 HIV HIV NNP cord-274707-mxh38hwd 92 41 and and CC cord-274707-mxh38hwd 92 42 HCV HCV NNP cord-274707-mxh38hwd 92 43 . . . cord-274707-mxh38hwd 93 1 In in IN cord-274707-mxh38hwd 93 2 general general JJ cord-274707-mxh38hwd 93 3 , , , cord-274707-mxh38hwd 93 4 this this DT cord-274707-mxh38hwd 93 5 kind kind NN cord-274707-mxh38hwd 93 6 of of IN cord-274707-mxh38hwd 93 7 assay assay NN cord-274707-mxh38hwd 93 8 shows show VBZ cord-274707-mxh38hwd 93 9 some some DT cord-274707-mxh38hwd 93 10 advantages advantage NNS cord-274707-mxh38hwd 93 11 such such JJ cord-274707-mxh38hwd 93 12 as as IN cord-274707-mxh38hwd 93 13 : : : cord-274707-mxh38hwd 93 14 it -PRON- PRP cord-274707-mxh38hwd 93 15 is be VBZ cord-274707-mxh38hwd 93 16 an an DT cord-274707-mxh38hwd 93 17 established establish VBN cord-274707-mxh38hwd 93 18 mature mature JJ cord-274707-mxh38hwd 93 19 technology technology NN cord-274707-mxh38hwd 93 20 ; ; : cord-274707-mxh38hwd 93 21 relative relative JJ cord-274707-mxh38hwd 93 22 ease ease NN cord-274707-mxh38hwd 93 23 of of IN cord-274707-mxh38hwd 93 24 manufacture manufacture NN cord-274707-mxh38hwd 93 25 since since IN cord-274707-mxh38hwd 93 26 equipment equipment NN cord-274707-mxh38hwd 93 27 and and CC cord-274707-mxh38hwd 93 28 processes process NNS cord-274707-mxh38hwd 93 29 are be VBP cord-274707-mxh38hwd 93 30 already already RB cord-274707-mxh38hwd 93 31 developed develop VBN cord-274707-mxh38hwd 93 32 and and CC cord-274707-mxh38hwd 93 33 available available JJ cord-274707-mxh38hwd 93 34 ; ; : cord-274707-mxh38hwd 93 35 easily easily RB cord-274707-mxh38hwd 93 36 scalable scalable JJ cord-274707-mxh38hwd 93 37 to to IN cord-274707-mxh38hwd 93 38 high high JJ cord-274707-mxh38hwd 93 39 volume volume NN cord-274707-mxh38hwd 93 40 production production NN cord-274707-mxh38hwd 93 41 , , , cord-274707-mxh38hwd 93 42 stable stable JJ cord-274707-mxh38hwd 93 43 , , , cord-274707-mxh38hwd 93 44 since since IN cord-274707-mxh38hwd 93 45 shelf shelf NN cord-274707-mxh38hwd 93 46 - - HYPH cord-274707-mxh38hwd 93 47 lives life NNS cord-274707-mxh38hwd 93 48 varies vary VBZ cord-274707-mxh38hwd 93 49 from from IN cord-274707-mxh38hwd 93 50 12 12 CD cord-274707-mxh38hwd 93 51 to to TO cord-274707-mxh38hwd 93 52 24 24 CD cord-274707-mxh38hwd 93 53 months month NNS cord-274707-mxh38hwd 93 54 often often RB cord-274707-mxh38hwd 93 55 without without IN cord-274707-mxh38hwd 93 56 refrigeration refrigeration NN cord-274707-mxh38hwd 93 57 ; ; : cord-274707-mxh38hwd 93 58 ease ease NN cord-274707-mxh38hwd 93 59 of of IN cord-274707-mxh38hwd 93 60 use use NN cord-274707-mxh38hwd 93 61 ; ; : cord-274707-mxh38hwd 93 62 relatively relatively RB cord-274707-mxh38hwd 93 63 low low JJ cord-274707-mxh38hwd 93 64 cost cost NN cord-274707-mxh38hwd 93 65 and and CC cord-274707-mxh38hwd 93 66 short short JJ cord-274707-mxh38hwd 93 67 timeline timeline NN cord-274707-mxh38hwd 93 68 for for IN cord-274707-mxh38hwd 93 69 development development NN cord-274707-mxh38hwd 93 70 and and CC cord-274707-mxh38hwd 93 71 approval approval NN cord-274707-mxh38hwd 93 72 ( ( -LRB- cord-274707-mxh38hwd 93 73 O'Farrell O'Farrell NNP cord-274707-mxh38hwd 93 74 , , , cord-274707-mxh38hwd 93 75 2009 2009 CD cord-274707-mxh38hwd 93 76 ) ) -RRB- cord-274707-mxh38hwd 93 77 . . . cord-274707-mxh38hwd 94 1 However however RB cord-274707-mxh38hwd 94 2 , , , cord-274707-mxh38hwd 94 3 we -PRON- PRP cord-274707-mxh38hwd 94 4 have have VBP cord-274707-mxh38hwd 94 5 found find VBN cord-274707-mxh38hwd 94 6 relatively relatively RB cord-274707-mxh38hwd 94 7 little little JJ cord-274707-mxh38hwd 94 8 current current JJ cord-274707-mxh38hwd 94 9 information information NN cord-274707-mxh38hwd 94 10 reporting report VBG cord-274707-mxh38hwd 94 11 the the DT cord-274707-mxh38hwd 94 12 diagnostic diagnostic JJ cord-274707-mxh38hwd 94 13 performance performance NN cord-274707-mxh38hwd 94 14 of of IN cord-274707-mxh38hwd 94 15 these these DT cord-274707-mxh38hwd 94 16 POC POC NNP cord-274707-mxh38hwd 94 17 devices device NNS cord-274707-mxh38hwd 94 18 using use VBG cord-274707-mxh38hwd 94 19 clinical clinical JJ cord-274707-mxh38hwd 94 20 samples sample NNS cord-274707-mxh38hwd 94 21 taken take VBN cord-274707-mxh38hwd 94 22 from from IN cord-274707-mxh38hwd 94 23 community community NN cord-274707-mxh38hwd 94 24 settings setting NNS cord-274707-mxh38hwd 94 25 . . . cord-274707-mxh38hwd 95 1 Relevant relevant JJ cord-274707-mxh38hwd 95 2 data data NN cord-274707-mxh38hwd 95 3 may may MD cord-274707-mxh38hwd 95 4 still still RB cord-274707-mxh38hwd 95 5 be be VB cord-274707-mxh38hwd 95 6 under under IN cord-274707-mxh38hwd 95 7 collection collection NN cord-274707-mxh38hwd 95 8 in in IN cord-274707-mxh38hwd 95 9 ongoing ongoing JJ cord-274707-mxh38hwd 95 10 studies study NNS cord-274707-mxh38hwd 95 11 or or CC cord-274707-mxh38hwd 95 12 may may MD cord-274707-mxh38hwd 95 13 not not RB cord-274707-mxh38hwd 95 14 be be VB cord-274707-mxh38hwd 95 15 published publish VBN cord-274707-mxh38hwd 95 16 publically publically RB cord-274707-mxh38hwd 95 17 . . . cord-274707-mxh38hwd 96 1 The the DT cord-274707-mxh38hwd 96 2 enzyme enzyme NN cord-274707-mxh38hwd 96 3 immunoassays immunoassays NNP cord-274707-mxh38hwd 96 4 ( ( -LRB- cord-274707-mxh38hwd 96 5 EIA EIA NNP cord-274707-mxh38hwd 96 6 ) ) -RRB- cord-274707-mxh38hwd 96 7 and and CC cord-274707-mxh38hwd 96 8 enzyme enzyme NN cord-274707-mxh38hwd 96 9 - - HYPH cord-274707-mxh38hwd 96 10 linked link VBN cord-274707-mxh38hwd 96 11 immunosorbent immunosorbent JJ cord-274707-mxh38hwd 96 12 assays assay NNS cord-274707-mxh38hwd 96 13 ( ( -LRB- cord-274707-mxh38hwd 96 14 ELISA ELISA NNP cord-274707-mxh38hwd 96 15 ) ) -RRB- cord-274707-mxh38hwd 96 16 are be VBP cord-274707-mxh38hwd 96 17 both both DT cord-274707-mxh38hwd 96 18 widely widely RB cord-274707-mxh38hwd 96 19 used use VBN cord-274707-mxh38hwd 96 20 as as IN cord-274707-mxh38hwd 96 21 diagnostic diagnostic JJ cord-274707-mxh38hwd 96 22 tools tool NNS cord-274707-mxh38hwd 96 23 for for IN cord-274707-mxh38hwd 96 24 the the DT cord-274707-mxh38hwd 96 25 detection detection NN cord-274707-mxh38hwd 96 26 and and CC cord-274707-mxh38hwd 96 27 quantification quantification NN cord-274707-mxh38hwd 96 28 of of IN cord-274707-mxh38hwd 96 29 specific specific JJ cord-274707-mxh38hwd 96 30 antigens antigen NNS cord-274707-mxh38hwd 96 31 or or CC cord-274707-mxh38hwd 96 32 antibodies antibody NNS cord-274707-mxh38hwd 96 33 in in IN cord-274707-mxh38hwd 96 34 a a DT cord-274707-mxh38hwd 96 35 given give VBN cord-274707-mxh38hwd 96 36 sample sample NN cord-274707-mxh38hwd 96 37 ( ( -LRB- cord-274707-mxh38hwd 96 38 Gan Gan NNP cord-274707-mxh38hwd 96 39 & & CC cord-274707-mxh38hwd 96 40 Patel Patel NNP cord-274707-mxh38hwd 96 41 , , , cord-274707-mxh38hwd 96 42 2013 2013 CD cord-274707-mxh38hwd 96 43 ) ) -RRB- cord-274707-mxh38hwd 96 44 . . . cord-274707-mxh38hwd 97 1 Both both DT cord-274707-mxh38hwd 97 2 techniques technique NNS cord-274707-mxh38hwd 97 3 share share VBP cord-274707-mxh38hwd 97 4 similar similar JJ cord-274707-mxh38hwd 97 5 basic basic JJ cord-274707-mxh38hwd 97 6 principles principle NNS cord-274707-mxh38hwd 97 7 and and CC cord-274707-mxh38hwd 97 8 are be VBP cord-274707-mxh38hwd 97 9 derived derive VBN cord-274707-mxh38hwd 97 10 from from IN cord-274707-mxh38hwd 97 11 the the DT cord-274707-mxh38hwd 97 12 radioimmunoassay radioimmunoassay JJ cord-274707-mxh38hwd 97 13 ( ( -LRB- cord-274707-mxh38hwd 97 14 RIA RIA NNP cord-274707-mxh38hwd 97 15 ) ) -RRB- cord-274707-mxh38hwd 97 16 . . . cord-274707-mxh38hwd 98 1 RIA RIA NNP cord-274707-mxh38hwd 98 2 was be VBD cord-274707-mxh38hwd 98 3 first first RB cord-274707-mxh38hwd 98 4 described describe VBN cord-274707-mxh38hwd 98 5 by by IN cord-274707-mxh38hwd 98 6 Berson Berson NNP cord-274707-mxh38hwd 98 7 and and CC cord-274707-mxh38hwd 98 8 Yalow Yalow NNP cord-274707-mxh38hwd 98 9 , , , cord-274707-mxh38hwd 98 10 for for IN cord-274707-mxh38hwd 98 11 which which WDT cord-274707-mxh38hwd 98 12 Yalow Yalow NNP cord-274707-mxh38hwd 98 13 was be VBD cord-274707-mxh38hwd 98 14 awarded award VBN cord-274707-mxh38hwd 98 15 the the DT cord-274707-mxh38hwd 98 16 Nobel Nobel NNP cord-274707-mxh38hwd 98 17 Prize Prize NNP cord-274707-mxh38hwd 98 18 in in IN cord-274707-mxh38hwd 98 19 1977 1977 CD cord-274707-mxh38hwd 98 20 , , , cord-274707-mxh38hwd 98 21 to to TO cord-274707-mxh38hwd 98 22 measure measure VB cord-274707-mxh38hwd 98 23 endogenous endogenous JJ cord-274707-mxh38hwd 98 24 plasma plasma NN cord-274707-mxh38hwd 98 25 insulin insulin NN cord-274707-mxh38hwd 98 26 ( ( -LRB- cord-274707-mxh38hwd 98 27 Yalow Yalow NNP cord-274707-mxh38hwd 98 28 & & CC cord-274707-mxh38hwd 98 29 Berson Berson NNP cord-274707-mxh38hwd 98 30 , , , cord-274707-mxh38hwd 98 31 1996 1996 CD cord-274707-mxh38hwd 98 32 ) ) -RRB- cord-274707-mxh38hwd 98 33 . . . cord-274707-mxh38hwd 99 1 RIA RIA NNP cord-274707-mxh38hwd 99 2 was be VBD cord-274707-mxh38hwd 99 3 then then RB cord-274707-mxh38hwd 99 4 developed develop VBN cord-274707-mxh38hwd 99 5 into into IN cord-274707-mxh38hwd 99 6 a a DT cord-274707-mxh38hwd 99 7 novel novel JJ cord-274707-mxh38hwd 99 8 technique technique NN cord-274707-mxh38hwd 99 9 to to TO cord-274707-mxh38hwd 99 10 detect detect VB cord-274707-mxh38hwd 99 11 and and CC cord-274707-mxh38hwd 99 12 measure measure VB cord-274707-mxh38hwd 99 13 biological biological JJ cord-274707-mxh38hwd 99 14 molecules molecule NNS cord-274707-mxh38hwd 99 15 present present JJ cord-274707-mxh38hwd 99 16 in in IN cord-274707-mxh38hwd 99 17 exceedingly exceedingly RB cord-274707-mxh38hwd 99 18 small small JJ cord-274707-mxh38hwd 99 19 quantities quantity NNS cord-274707-mxh38hwd 99 20 , , , cord-274707-mxh38hwd 99 21 paving pave VBG cord-274707-mxh38hwd 99 22 the the DT cord-274707-mxh38hwd 99 23 way way NN cord-274707-mxh38hwd 99 24 for for IN cord-274707-mxh38hwd 99 25 more more JJR cord-274707-mxh38hwd 99 26 analysis analysis NN cord-274707-mxh38hwd 99 27 and and CC cord-274707-mxh38hwd 99 28 detection detection NN cord-274707-mxh38hwd 99 29 of of IN cord-274707-mxh38hwd 99 30 countless countless JJ cord-274707-mxh38hwd 99 31 other other JJ cord-274707-mxh38hwd 99 32 biological biological JJ cord-274707-mxh38hwd 99 33 molecules molecule NNS cord-274707-mxh38hwd 99 34 , , , cord-274707-mxh38hwd 99 35 including include VBG cord-274707-mxh38hwd 99 36 hormones hormone NNS cord-274707-mxh38hwd 99 37 , , , cord-274707-mxh38hwd 99 38 peptides peptide NNS cord-274707-mxh38hwd 99 39 and and CC cord-274707-mxh38hwd 99 40 proteins protein NNS cord-274707-mxh38hwd 99 41 . . . cord-274707-mxh38hwd 100 1 Because because IN cord-274707-mxh38hwd 100 2 of of IN cord-274707-mxh38hwd 100 3 the the DT cord-274707-mxh38hwd 100 4 safety safety NN cord-274707-mxh38hwd 100 5 concerns concern NNS cord-274707-mxh38hwd 100 6 regarding regard VBG cord-274707-mxh38hwd 100 7 its -PRON- PRP$ cord-274707-mxh38hwd 100 8 use use NN cord-274707-mxh38hwd 100 9 of of IN cord-274707-mxh38hwd 100 10 radioactivity radioactivity NN cord-274707-mxh38hwd 100 11 , , , cord-274707-mxh38hwd 100 12 RIA RIA NNP cord-274707-mxh38hwd 100 13 assays assay NNS cord-274707-mxh38hwd 100 14 were be VBD cord-274707-mxh38hwd 100 15 modified modify VBN cord-274707-mxh38hwd 100 16 by by IN cord-274707-mxh38hwd 100 17 replacing replace VBG cord-274707-mxh38hwd 100 18 the the DT cord-274707-mxh38hwd 100 19 radioisotope radioisotope NN cord-274707-mxh38hwd 100 20 with with IN cord-274707-mxh38hwd 100 21 an an DT cord-274707-mxh38hwd 100 22 enzyme enzyme NN cord-274707-mxh38hwd 100 23 , , , cord-274707-mxh38hwd 100 24 thus thus RB cord-274707-mxh38hwd 100 25 creating create VBG cord-274707-mxh38hwd 100 26 the the DT cord-274707-mxh38hwd 100 27 modern modern JJ cord-274707-mxh38hwd 100 28 - - HYPH cord-274707-mxh38hwd 100 29 day day NN cord-274707-mxh38hwd 100 30 EIA EIA NNP cord-274707-mxh38hwd 100 31 and and CC cord-274707-mxh38hwd 100 32 ELISA ELISA NNP cord-274707-mxh38hwd 100 33 ( ( -LRB- cord-274707-mxh38hwd 100 34 Gan Gan NNP cord-274707-mxh38hwd 100 35 & & CC cord-274707-mxh38hwd 100 36 Patel Patel NNP cord-274707-mxh38hwd 100 37 , , , cord-274707-mxh38hwd 100 38 2013 2013 CD cord-274707-mxh38hwd 100 39 ) ) -RRB- cord-274707-mxh38hwd 100 40 . . . cord-274707-mxh38hwd 101 1 Both both DT cord-274707-mxh38hwd 101 2 assays assay NNS cord-274707-mxh38hwd 101 3 use use VBP cord-274707-mxh38hwd 101 4 the the DT cord-274707-mxh38hwd 101 5 basic basic JJ cord-274707-mxh38hwd 101 6 immunology immunology NN cord-274707-mxh38hwd 101 7 concept concept NN cord-274707-mxh38hwd 101 8 of of IN cord-274707-mxh38hwd 101 9 an an DT cord-274707-mxh38hwd 101 10 antigen antigen NN cord-274707-mxh38hwd 101 11 binding bind VBG cord-274707-mxh38hwd 101 12 to to IN cord-274707-mxh38hwd 101 13 its -PRON- PRP$ cord-274707-mxh38hwd 101 14 specific specific JJ cord-274707-mxh38hwd 101 15 antibody antibody NN cord-274707-mxh38hwd 101 16 , , , cord-274707-mxh38hwd 101 17 which which WDT cord-274707-mxh38hwd 101 18 allows allow VBZ cord-274707-mxh38hwd 101 19 detection detection NN cord-274707-mxh38hwd 101 20 of of IN cord-274707-mxh38hwd 101 21 small small JJ cord-274707-mxh38hwd 101 22 quantities quantity NNS cord-274707-mxh38hwd 101 23 of of IN cord-274707-mxh38hwd 101 24 antigens antigen NNS cord-274707-mxh38hwd 101 25 such such JJ cord-274707-mxh38hwd 101 26 as as IN cord-274707-mxh38hwd 101 27 proteins protein NNS cord-274707-mxh38hwd 101 28 , , , cord-274707-mxh38hwd 101 29 peptides peptide NNS cord-274707-mxh38hwd 101 30 , , , cord-274707-mxh38hwd 101 31 hormones hormone NNS cord-274707-mxh38hwd 101 32 or or CC cord-274707-mxh38hwd 101 33 even even RB cord-274707-mxh38hwd 101 34 antibodies antibody NNS cord-274707-mxh38hwd 101 35 in in IN cord-274707-mxh38hwd 101 36 a a DT cord-274707-mxh38hwd 101 37 fluid fluid JJ cord-274707-mxh38hwd 101 38 sample sample NN cord-274707-mxh38hwd 101 39 . . . cord-274707-mxh38hwd 102 1 Those those DT cord-274707-mxh38hwd 102 2 assays assay NNS cord-274707-mxh38hwd 102 3 utilize utilize VBP cord-274707-mxh38hwd 102 4 enzyme enzyme NN cord-274707-mxh38hwd 102 5 - - HYPH cord-274707-mxh38hwd 102 6 labelled label VBN cord-274707-mxh38hwd 102 7 antigens antigen NNS cord-274707-mxh38hwd 102 8 and and CC cord-274707-mxh38hwd 102 9 antibodies antibody NNS cord-274707-mxh38hwd 102 10 to to TO cord-274707-mxh38hwd 102 11 detect detect VB cord-274707-mxh38hwd 102 12 biological biological JJ cord-274707-mxh38hwd 102 13 molecules molecule NNS cord-274707-mxh38hwd 102 14 ; ; : cord-274707-mxh38hwd 102 15 the the DT cord-274707-mxh38hwd 102 16 most most RBS cord-274707-mxh38hwd 102 17 used use VBN cord-274707-mxh38hwd 102 18 enzymes enzyme NNS cord-274707-mxh38hwd 102 19 being be VBG cord-274707-mxh38hwd 102 20 alkaline alkaline JJ cord-274707-mxh38hwd 102 21 phosphatase phosphatase NN cord-274707-mxh38hwd 102 22 ( ( -LRB- cord-274707-mxh38hwd 102 23 EC EC NNP cord-274707-mxh38hwd 102 24 3.1.3.1 3.1.3.1 CD cord-274707-mxh38hwd 102 25 ) ) -RRB- cord-274707-mxh38hwd 102 26 and and CC cord-274707-mxh38hwd 102 27 glucose glucose NN cord-274707-mxh38hwd 102 28 oxidase oxidase NN cord-274707-mxh38hwd 102 29 ( ( -LRB- cord-274707-mxh38hwd 102 30 E. E. NNP cord-274707-mxh38hwd 102 31 C. C. NNP cord-274707-mxh38hwd 102 32 1.1.3.4 1.1.3.4 CD cord-274707-mxh38hwd 102 33 ) ) -RRB- cord-274707-mxh38hwd 102 34 . . . cord-274707-mxh38hwd 103 1 The the DT cord-274707-mxh38hwd 103 2 antigen antigen NN cord-274707-mxh38hwd 103 3 in in IN cord-274707-mxh38hwd 103 4 fluid fluid JJ cord-274707-mxh38hwd 103 5 phase phase NN cord-274707-mxh38hwd 103 6 is be VBZ cord-274707-mxh38hwd 103 7 immobilized immobilize VBN cord-274707-mxh38hwd 103 8 , , , cord-274707-mxh38hwd 103 9 usually usually RB cord-274707-mxh38hwd 103 10 in in IN cord-274707-mxh38hwd 103 11 a a DT cord-274707-mxh38hwd 103 12 96-well 96-well CD cord-274707-mxh38hwd 103 13 microtiter microtiter NN cord-274707-mxh38hwd 103 14 plate plate NN cord-274707-mxh38hwd 103 15 . . . cord-274707-mxh38hwd 104 1 The the DT cord-274707-mxh38hwd 104 2 antigen antigen NN cord-274707-mxh38hwd 104 3 can can MD cord-274707-mxh38hwd 104 4 bind bind VB cord-274707-mxh38hwd 104 5 to to IN cord-274707-mxh38hwd 104 6 a a DT cord-274707-mxh38hwd 104 7 specific specific JJ cord-274707-mxh38hwd 104 8 antibody antibody NN cord-274707-mxh38hwd 104 9 , , , cord-274707-mxh38hwd 104 10 which which WDT cord-274707-mxh38hwd 104 11 is be VBZ cord-274707-mxh38hwd 104 12 itself -PRON- PRP cord-274707-mxh38hwd 104 13 subsequently subsequently RB cord-274707-mxh38hwd 104 14 detected detect VBN cord-274707-mxh38hwd 104 15 by by IN cord-274707-mxh38hwd 104 16 a a DT cord-274707-mxh38hwd 104 17 secondary secondary JJ cord-274707-mxh38hwd 104 18 , , , cord-274707-mxh38hwd 104 19 enzyme enzyme NN cord-274707-mxh38hwd 104 20 - - HYPH cord-274707-mxh38hwd 104 21 coupled couple VBN cord-274707-mxh38hwd 104 22 antibody antibody NN cord-274707-mxh38hwd 104 23 . . . cord-274707-mxh38hwd 105 1 A a DT cord-274707-mxh38hwd 105 2 chromogenic chromogenic JJ cord-274707-mxh38hwd 105 3 substrate substrate NN cord-274707-mxh38hwd 105 4 for for IN cord-274707-mxh38hwd 105 5 the the DT cord-274707-mxh38hwd 105 6 enzyme enzyme NN cord-274707-mxh38hwd 105 7 yields yield VBZ cord-274707-mxh38hwd 105 8 a a DT cord-274707-mxh38hwd 105 9 visible visible JJ cord-274707-mxh38hwd 105 10 colour colour NN cord-274707-mxh38hwd 105 11 change change NN cord-274707-mxh38hwd 105 12 or or CC cord-274707-mxh38hwd 105 13 fluorescence fluorescence NN cord-274707-mxh38hwd 105 14 , , , cord-274707-mxh38hwd 105 15 indicating indicate VBG cord-274707-mxh38hwd 105 16 then then RB cord-274707-mxh38hwd 105 17 the the DT cord-274707-mxh38hwd 105 18 presence presence NN cord-274707-mxh38hwd 105 19 of of IN cord-274707-mxh38hwd 105 20 the the DT cord-274707-mxh38hwd 105 21 antigen antigen NN cord-274707-mxh38hwd 105 22 . . . cord-274707-mxh38hwd 106 1 Quantitative quantitative JJ cord-274707-mxh38hwd 106 2 or or CC cord-274707-mxh38hwd 106 3 qualitative qualitative JJ cord-274707-mxh38hwd 106 4 measures measure NNS cord-274707-mxh38hwd 106 5 can can MD cord-274707-mxh38hwd 106 6 be be VB cord-274707-mxh38hwd 106 7 assessed assess VBN cord-274707-mxh38hwd 106 8 based base VBN cord-274707-mxh38hwd 106 9 on on IN cord-274707-mxh38hwd 106 10 such such JJ cord-274707-mxh38hwd 106 11 colorimetric colorimetric JJ cord-274707-mxh38hwd 106 12 reading reading NN cord-274707-mxh38hwd 106 13 . . . cord-274707-mxh38hwd 107 1 ( ( -LRB- cord-274707-mxh38hwd 107 2 Gan Gan NNP cord-274707-mxh38hwd 107 3 & & CC cord-274707-mxh38hwd 107 4 Patel Patel NNP cord-274707-mxh38hwd 107 5 , , , cord-274707-mxh38hwd 107 6 2013 2013 CD cord-274707-mxh38hwd 107 7 ) ) -RRB- cord-274707-mxh38hwd 107 8 . . . cord-274707-mxh38hwd 108 1 Although although IN cord-274707-mxh38hwd 108 2 ELISA ELISA NNP cord-274707-mxh38hwd 108 3 methodology methodology NN cord-274707-mxh38hwd 108 4 could could MD cord-274707-mxh38hwd 108 5 help help VB cord-274707-mxh38hwd 108 6 track track VB cord-274707-mxh38hwd 108 7 antigen antigen NN cord-274707-mxh38hwd 108 8 exposure exposure NN cord-274707-mxh38hwd 108 9 , , , cord-274707-mxh38hwd 108 10 it -PRON- PRP cord-274707-mxh38hwd 108 11 has have VBZ cord-274707-mxh38hwd 108 12 some some DT cord-274707-mxh38hwd 108 13 limitations limitation NNS cord-274707-mxh38hwd 108 14 : : : cord-274707-mxh38hwd 108 15 the the DT cord-274707-mxh38hwd 108 16 enzyme enzyme NN cord-274707-mxh38hwd 108 17 - - HYPH cord-274707-mxh38hwd 108 18 mediated mediate VBN cord-274707-mxh38hwd 108 19 colour colour NN cord-274707-mxh38hwd 108 20 change change NN cord-274707-mxh38hwd 108 21 will will MD cord-274707-mxh38hwd 108 22 react react VB cord-274707-mxh38hwd 108 23 indefinitely indefinitely RB cord-274707-mxh38hwd 108 24 . . . cord-274707-mxh38hwd 109 1 Over over IN cord-274707-mxh38hwd 109 2 a a DT cord-274707-mxh38hwd 109 3 sufficient sufficient JJ cord-274707-mxh38hwd 109 4 long long JJ cord-274707-mxh38hwd 109 5 period period NN cord-274707-mxh38hwd 109 6 of of IN cord-274707-mxh38hwd 109 7 time time NN cord-274707-mxh38hwd 109 8 , , , cord-274707-mxh38hwd 109 9 the the DT cord-274707-mxh38hwd 109 10 colour colour NN cord-274707-mxh38hwd 109 11 strength strength NN cord-274707-mxh38hwd 109 12 will will MD cord-274707-mxh38hwd 109 13 inaccurately inaccurately RB cord-274707-mxh38hwd 109 14 reflect reflect VB cord-274707-mxh38hwd 109 15 the the DT cord-274707-mxh38hwd 109 16 amount amount NN cord-274707-mxh38hwd 109 17 of of IN cord-274707-mxh38hwd 109 18 primary primary JJ cord-274707-mxh38hwd 109 19 antibody antibody NN cord-274707-mxh38hwd 109 20 present present NN cord-274707-mxh38hwd 109 21 , , , cord-274707-mxh38hwd 109 22 yielding yield VBG cord-274707-mxh38hwd 109 23 false false JJ cord-274707-mxh38hwd 109 24 - - HYPH cord-274707-mxh38hwd 109 25 positive positive JJ cord-274707-mxh38hwd 109 26 results result NNS cord-274707-mxh38hwd 109 27 ; ; : cord-274707-mxh38hwd 109 28 to to TO cord-274707-mxh38hwd 109 29 detect detect VB cord-274707-mxh38hwd 109 30 a a DT cord-274707-mxh38hwd 109 31 given give VBN cord-274707-mxh38hwd 109 32 antibody antibody NN cord-274707-mxh38hwd 109 33 or or CC cord-274707-mxh38hwd 109 34 antigen antigen NN cord-274707-mxh38hwd 109 35 , , , cord-274707-mxh38hwd 109 36 a a DT cord-274707-mxh38hwd 109 37 known know VBN cord-274707-mxh38hwd 109 38 reciprocal reciprocal JJ cord-274707-mxh38hwd 109 39 antigen antigen NN cord-274707-mxh38hwd 109 40 or or CC cord-274707-mxh38hwd 109 41 antibody antibody NN cord-274707-mxh38hwd 109 42 must must MD cord-274707-mxh38hwd 109 43 be be VB cord-274707-mxh38hwd 109 44 generated generate VBN cord-274707-mxh38hwd 109 45 and and CC cord-274707-mxh38hwd 109 46 , , , cord-274707-mxh38hwd 109 47 nonspecific nonspecific JJ cord-274707-mxh38hwd 109 48 binding binding NN cord-274707-mxh38hwd 109 49 of of IN cord-274707-mxh38hwd 109 50 the the DT cord-274707-mxh38hwd 109 51 antibody antibody NN cord-274707-mxh38hwd 109 52 or or CC cord-274707-mxh38hwd 109 53 antigen antigen NN cord-274707-mxh38hwd 109 54 to to IN cord-274707-mxh38hwd 109 55 the the DT cord-274707-mxh38hwd 109 56 plate plate NN cord-274707-mxh38hwd 109 57 will will MD cord-274707-mxh38hwd 109 58 lead lead VB cord-274707-mxh38hwd 109 59 to to IN cord-274707-mxh38hwd 109 60 a a DT cord-274707-mxh38hwd 109 61 falsely falsely RB cord-274707-mxh38hwd 109 62 high high JJ cord-274707-mxh38hwd 109 63 - - HYPH cord-274707-mxh38hwd 109 64 positive positive JJ cord-274707-mxh38hwd 109 65 result result NN cord-274707-mxh38hwd 109 66 ( ( -LRB- cord-274707-mxh38hwd 109 67 Gan Gan NNP cord-274707-mxh38hwd 109 68 & & CC cord-274707-mxh38hwd 109 69 Patel Patel NNP cord-274707-mxh38hwd 109 70 , , , cord-274707-mxh38hwd 109 71 2013 2013 CD cord-274707-mxh38hwd 109 72 ) ) -RRB- cord-274707-mxh38hwd 109 73 . . . cord-274707-mxh38hwd 110 1 In in IN cord-274707-mxh38hwd 110 2 acute acute JJ cord-274707-mxh38hwd 110 3 respiratory respiratory JJ cord-274707-mxh38hwd 110 4 infection infection NN cord-274707-mxh38hwd 110 5 , , , cord-274707-mxh38hwd 110 6 RT RT NNP cord-274707-mxh38hwd 110 7 - - HYPH cord-274707-mxh38hwd 110 8 PCR PCR NNP cord-274707-mxh38hwd 110 9 is be VBZ cord-274707-mxh38hwd 110 10 routinely routinely RB cord-274707-mxh38hwd 110 11 used use VBN cord-274707-mxh38hwd 110 12 to to TO cord-274707-mxh38hwd 110 13 detect detect VB cord-274707-mxh38hwd 110 14 causative causative JJ cord-274707-mxh38hwd 110 15 viruses virus NNS cord-274707-mxh38hwd 110 16 from from IN cord-274707-mxh38hwd 110 17 respiratory respiratory JJ cord-274707-mxh38hwd 110 18 secretions secretion NNS cord-274707-mxh38hwd 110 19 . . . cord-274707-mxh38hwd 111 1 PCR PCR NNP cord-274707-mxh38hwd 111 2 is be VBZ cord-274707-mxh38hwd 111 3 an an DT cord-274707-mxh38hwd 111 4 enzyme enzyme NN cord-274707-mxh38hwd 111 5 - - HYPH cord-274707-mxh38hwd 111 6 driven drive VBN cord-274707-mxh38hwd 111 7 process process NN cord-274707-mxh38hwd 111 8 for for IN cord-274707-mxh38hwd 111 9 replicating replicate VBG cord-274707-mxh38hwd 111 10 DNA DNA NNP cord-274707-mxh38hwd 111 11 in in IN cord-274707-mxh38hwd 111 12 vitro vitro FW cord-274707-mxh38hwd 111 13 . . . cord-274707-mxh38hwd 112 1 PCR PCR NNP cord-274707-mxh38hwd 112 2 can can MD cord-274707-mxh38hwd 112 3 produce produce VB cord-274707-mxh38hwd 112 4 enough enough JJ cord-274707-mxh38hwd 112 5 amounts amount NNS cord-274707-mxh38hwd 112 6 of of IN cord-274707-mxh38hwd 112 7 DNA dna NN cord-274707-mxh38hwd 112 8 so so IN cord-274707-mxh38hwd 112 9 that that IN cord-274707-mxh38hwd 112 10 pathogens pathogen NNS cord-274707-mxh38hwd 112 11 can can MD cord-274707-mxh38hwd 112 12 be be VB cord-274707-mxh38hwd 112 13 detected detect VBN cord-274707-mxh38hwd 112 14 and and CC cord-274707-mxh38hwd 112 15 identified identify VBN cord-274707-mxh38hwd 112 16 . . . cord-274707-mxh38hwd 113 1 Because because IN cord-274707-mxh38hwd 113 2 each each DT cord-274707-mxh38hwd 113 3 pathogen pathogen NN cord-274707-mxh38hwd 113 4 has have VBZ cord-274707-mxh38hwd 113 5 a a DT cord-274707-mxh38hwd 113 6 unique unique JJ cord-274707-mxh38hwd 113 7 complement complement NN cord-274707-mxh38hwd 113 8 of of IN cord-274707-mxh38hwd 113 9 DNA DNA NNP cord-274707-mxh38hwd 113 10 or or CC cord-274707-mxh38hwd 113 11 RNA RNA NNP cord-274707-mxh38hwd 113 12 , , , cord-274707-mxh38hwd 113 13 those those DT cord-274707-mxh38hwd 113 14 molecules molecule NNS cord-274707-mxh38hwd 113 15 can can MD cord-274707-mxh38hwd 113 16 function function VB cord-274707-mxh38hwd 113 17 as as IN cord-274707-mxh38hwd 113 18 a a DT cord-274707-mxh38hwd 113 19 molecular molecular JJ cord-274707-mxh38hwd 113 20 fingerprint fingerprint NN cord-274707-mxh38hwd 113 21 to to TO cord-274707-mxh38hwd 113 22 help help VB cord-274707-mxh38hwd 113 23 identify identify VB cord-274707-mxh38hwd 113 24 what what WP cord-274707-mxh38hwd 113 25 is be VBZ cord-274707-mxh38hwd 113 26 the the DT cord-274707-mxh38hwd 113 27 organism organism NN cord-274707-mxh38hwd 113 28 causing cause VBG cord-274707-mxh38hwd 113 29 one one CD cord-274707-mxh38hwd 113 30 disease disease NN cord-274707-mxh38hwd 113 31 . . . cord-274707-mxh38hwd 114 1 In in IN cord-274707-mxh38hwd 114 2 this this DT cord-274707-mxh38hwd 114 3 technique technique NN cord-274707-mxh38hwd 114 4 a a DT cord-274707-mxh38hwd 114 5 segment segment NN cord-274707-mxh38hwd 114 6 of of IN cord-274707-mxh38hwd 114 7 DNA DNA NNP cord-274707-mxh38hwd 114 8 is be VBZ cord-274707-mxh38hwd 114 9 copied copy VBN cord-274707-mxh38hwd 114 10 in in IN cord-274707-mxh38hwd 114 11 vitro vitro FW cord-274707-mxh38hwd 114 12 by by IN cord-274707-mxh38hwd 114 13 using use VBG cord-274707-mxh38hwd 114 14 a a DT cord-274707-mxh38hwd 114 15 thermostable thermostable JJ cord-274707-mxh38hwd 114 16 DNA dna NN cord-274707-mxh38hwd 114 17 polymerase polymerase NN cord-274707-mxh38hwd 114 18 enzyme enzyme NN cord-274707-mxh38hwd 114 19 in in IN cord-274707-mxh38hwd 114 20 the the DT cord-274707-mxh38hwd 114 21 presence presence NN cord-274707-mxh38hwd 114 22 of of IN cord-274707-mxh38hwd 114 23 buffer buffer NN cord-274707-mxh38hwd 114 24 , , , cord-274707-mxh38hwd 114 25 magnesium magnesium NN cord-274707-mxh38hwd 114 26 , , , cord-274707-mxh38hwd 114 27 deoxyribonucleoside deoxyribonucleoside NNP cord-274707-mxh38hwd 114 28 triphosphates triphosphate NNS cord-274707-mxh38hwd 114 29 and and CC cord-274707-mxh38hwd 114 30 primers primer NNS cord-274707-mxh38hwd 114 31 . . . cord-274707-mxh38hwd 115 1 Oligonucleotide oligonucleotide JJ cord-274707-mxh38hwd 115 2 primers primer NNS cord-274707-mxh38hwd 115 3 complementary complementary JJ cord-274707-mxh38hwd 115 4 to to IN cord-274707-mxh38hwd 115 5 regions region NNS cord-274707-mxh38hwd 115 6 on on IN cord-274707-mxh38hwd 115 7 the the DT cord-274707-mxh38hwd 115 8 coding coding NN cord-274707-mxh38hwd 115 9 and and CC cord-274707-mxh38hwd 115 10 the the DT cord-274707-mxh38hwd 115 11 noncoding noncoding JJ cord-274707-mxh38hwd 115 12 strand strand NN cord-274707-mxh38hwd 115 13 of of IN cord-274707-mxh38hwd 115 14 the the DT cord-274707-mxh38hwd 115 15 DNA dna NN cord-274707-mxh38hwd 115 16 template template NN cord-274707-mxh38hwd 115 17 are be VBP cord-274707-mxh38hwd 115 18 responsible responsible JJ cord-274707-mxh38hwd 115 19 for for IN cord-274707-mxh38hwd 115 20 specificity specificity NN cord-274707-mxh38hwd 115 21 in in IN cord-274707-mxh38hwd 115 22 the the DT cord-274707-mxh38hwd 115 23 reaction reaction NN cord-274707-mxh38hwd 115 24 , , , cord-274707-mxh38hwd 115 25 determining determine VBG cord-274707-mxh38hwd 115 26 which which WDT cord-274707-mxh38hwd 115 27 region region NN cord-274707-mxh38hwd 115 28 of of IN cord-274707-mxh38hwd 115 29 the the DT cord-274707-mxh38hwd 115 30 DNA dna NN cord-274707-mxh38hwd 115 31 becomes become VBZ cord-274707-mxh38hwd 115 32 amplified amplify VBN cord-274707-mxh38hwd 115 33 . . . cord-274707-mxh38hwd 116 1 As as IN cord-274707-mxh38hwd 116 2 the the DT cord-274707-mxh38hwd 116 3 primers primer NNS cord-274707-mxh38hwd 116 4 anneal anneal VBP cord-274707-mxh38hwd 116 5 to to IN cord-274707-mxh38hwd 116 6 their -PRON- PRP$ cord-274707-mxh38hwd 116 7 complementary complementary JJ cord-274707-mxh38hwd 116 8 regions region NNS cord-274707-mxh38hwd 116 9 of of IN cord-274707-mxh38hwd 116 10 DNA dna NN cord-274707-mxh38hwd 116 11 , , , cord-274707-mxh38hwd 116 12 DNA dna NN cord-274707-mxh38hwd 116 13 polymerases polymerase NNS cord-274707-mxh38hwd 116 14 attach attach VBP cord-274707-mxh38hwd 116 15 to to IN cord-274707-mxh38hwd 116 16 the the DT cord-274707-mxh38hwd 116 17 primer primer NN cord-274707-mxh38hwd 116 18 - - HYPH cord-274707-mxh38hwd 116 19 template template NN cord-274707-mxh38hwd 116 20 complexes complex NNS cord-274707-mxh38hwd 116 21 and and CC cord-274707-mxh38hwd 116 22 extend extend VB cord-274707-mxh38hwd 116 23 the the DT cord-274707-mxh38hwd 116 24 DNA dna NN cord-274707-mxh38hwd 116 25 strands strand NNS cord-274707-mxh38hwd 116 26 , , , cord-274707-mxh38hwd 116 27 producing produce VBG cord-274707-mxh38hwd 116 28 a a DT cord-274707-mxh38hwd 116 29 copy copy NN cord-274707-mxh38hwd 116 30 of of IN cord-274707-mxh38hwd 116 31 the the DT cord-274707-mxh38hwd 116 32 DNA dna NN cord-274707-mxh38hwd 116 33 . . . cord-274707-mxh38hwd 117 1 Each each DT cord-274707-mxh38hwd 117 2 copy copy NN cord-274707-mxh38hwd 117 3 may may MD cord-274707-mxh38hwd 117 4 then then RB cord-274707-mxh38hwd 117 5 serve serve VB cord-274707-mxh38hwd 117 6 as as IN cord-274707-mxh38hwd 117 7 another another DT cord-274707-mxh38hwd 117 8 template template NN cord-274707-mxh38hwd 117 9 for for IN cord-274707-mxh38hwd 117 10 further further JJ cord-274707-mxh38hwd 117 11 amplification amplification NN cord-274707-mxh38hwd 117 12 . . . cord-274707-mxh38hwd 118 1 Multiple multiple JJ cord-274707-mxh38hwd 118 2 rounds round NNS cord-274707-mxh38hwd 118 3 of of IN cord-274707-mxh38hwd 118 4 heating heating NN cord-274707-mxh38hwd 118 5 and and CC cord-274707-mxh38hwd 118 6 cooling cooling NN cord-274707-mxh38hwd 118 7 of of IN cord-274707-mxh38hwd 118 8 the the DT cord-274707-mxh38hwd 118 9 reaction reaction NN cord-274707-mxh38hwd 118 10 mixture mixture NN cord-274707-mxh38hwd 118 11 in in IN cord-274707-mxh38hwd 118 12 a a DT cord-274707-mxh38hwd 118 13 thermal thermal JJ cord-274707-mxh38hwd 118 14 cycler cycler NN cord-274707-mxh38hwd 118 15 produce produce NN cord-274707-mxh38hwd 118 16 rounds round NNS cord-274707-mxh38hwd 118 17 of of IN cord-274707-mxh38hwd 118 18 melting melting NN cord-274707-mxh38hwd 118 19 of of IN cord-274707-mxh38hwd 118 20 the the DT cord-274707-mxh38hwd 118 21 double double RB cord-274707-mxh38hwd 118 22 - - HYPH cord-274707-mxh38hwd 118 23 stranded strand VBN cord-274707-mxh38hwd 118 24 DNA dna NN cord-274707-mxh38hwd 118 25 , , , cord-274707-mxh38hwd 118 26 annealing annealing NN cord-274707-mxh38hwd 118 27 of of IN cord-274707-mxh38hwd 118 28 primer primer NN cord-274707-mxh38hwd 118 29 to to IN cord-274707-mxh38hwd 118 30 single single RB cord-274707-mxh38hwd 118 31 - - HYPH cord-274707-mxh38hwd 118 32 stranded strand VBN cord-274707-mxh38hwd 118 33 templates template NNS cord-274707-mxh38hwd 118 34 , , , cord-274707-mxh38hwd 118 35 and and CC cord-274707-mxh38hwd 118 36 extension extension NN cord-274707-mxh38hwd 118 37 of of IN cord-274707-mxh38hwd 118 38 DNA dna NN cord-274707-mxh38hwd 118 39 strands strand NNS cord-274707-mxh38hwd 118 40 , , , cord-274707-mxh38hwd 118 41 to to TO cord-274707-mxh38hwd 118 42 produce produce VB cord-274707-mxh38hwd 118 43 a a DT cord-274707-mxh38hwd 118 44 logarithmic logarithmic JJ cord-274707-mxh38hwd 118 45 increase increase NN cord-274707-mxh38hwd 118 46 in in IN cord-274707-mxh38hwd 118 47 DNA dna NN cord-274707-mxh38hwd 118 48 . . . cord-274707-mxh38hwd 119 1 In in IN cord-274707-mxh38hwd 119 2 the the DT cord-274707-mxh38hwd 119 3 ideal ideal JJ cord-274707-mxh38hwd 119 4 scenario scenario NN cord-274707-mxh38hwd 119 5 , , , cord-274707-mxh38hwd 119 6 the the DT cord-274707-mxh38hwd 119 7 primers primer NNS cord-274707-mxh38hwd 119 8 chosen choose VBN cord-274707-mxh38hwd 119 9 in in IN cord-274707-mxh38hwd 119 10 the the DT cord-274707-mxh38hwd 119 11 PCR PCR NNP cord-274707-mxh38hwd 119 12 are be VBP cord-274707-mxh38hwd 119 13 specific specific JJ cord-274707-mxh38hwd 119 14 for for IN cord-274707-mxh38hwd 119 15 a a DT cord-274707-mxh38hwd 119 16 pathogen pathogen NN cord-274707-mxh38hwd 119 17 gene gene NN cord-274707-mxh38hwd 119 18 , , , cord-274707-mxh38hwd 119 19 and and CC cord-274707-mxh38hwd 119 20 hence hence RB cord-274707-mxh38hwd 119 21 do do VBP cord-274707-mxh38hwd 119 22 not not RB cord-274707-mxh38hwd 119 23 amplify amplify VB cord-274707-mxh38hwd 119 24 nonspecific nonspecific JJ cord-274707-mxh38hwd 119 25 targets target NNS cord-274707-mxh38hwd 119 26 such such JJ cord-274707-mxh38hwd 119 27 as as IN cord-274707-mxh38hwd 119 28 human human JJ cord-274707-mxh38hwd 119 29 genes gene NNS cord-274707-mxh38hwd 119 30 . . . cord-274707-mxh38hwd 120 1 Theoretically theoretically RB cord-274707-mxh38hwd 120 2 , , , cord-274707-mxh38hwd 120 3 one one PRP cord-274707-mxh38hwd 120 4 could could MD cord-274707-mxh38hwd 120 5 start start VB cord-274707-mxh38hwd 120 6 with with IN cord-274707-mxh38hwd 120 7 a a DT cord-274707-mxh38hwd 120 8 single single JJ cord-274707-mxh38hwd 120 9 copy copy NN cord-274707-mxh38hwd 120 10 of of IN cord-274707-mxh38hwd 120 11 the the DT cord-274707-mxh38hwd 120 12 target target NN cord-274707-mxh38hwd 120 13 pathogen pathogen NN cord-274707-mxh38hwd 120 14 gene gene NN cord-274707-mxh38hwd 120 15 present present JJ cord-274707-mxh38hwd 120 16 in in IN cord-274707-mxh38hwd 120 17 the the DT cord-274707-mxh38hwd 120 18 reaction reaction NN cord-274707-mxh38hwd 120 19 and and CC cord-274707-mxh38hwd 120 20 generate generate VB cord-274707-mxh38hwd 120 21 billions billion NNS cord-274707-mxh38hwd 120 22 of of IN cord-274707-mxh38hwd 120 23 copies copy NNS cord-274707-mxh38hwd 120 24 of of IN cord-274707-mxh38hwd 120 25 DNA DNA NNP cord-274707-mxh38hwd 120 26 from from IN cord-274707-mxh38hwd 120 27 that that DT cord-274707-mxh38hwd 120 28 gene gene NN cord-274707-mxh38hwd 120 29 ( ( -LRB- cord-274707-mxh38hwd 120 30 Fredricks Fredricks NNP cord-274707-mxh38hwd 120 31 & & CC cord-274707-mxh38hwd 120 32 Relman Relman NNP cord-274707-mxh38hwd 120 33 , , , cord-274707-mxh38hwd 120 34 1999 1999 CD cord-274707-mxh38hwd 120 35 ) ) -RRB- cord-274707-mxh38hwd 120 36 . . . cord-274707-mxh38hwd 121 1 There there EX cord-274707-mxh38hwd 121 2 are be VBP cord-274707-mxh38hwd 121 3 several several JJ cord-274707-mxh38hwd 121 4 approaches approach NNS cord-274707-mxh38hwd 121 5 for for IN cord-274707-mxh38hwd 121 6 using use VBG cord-274707-mxh38hwd 121 7 PCR PCR NNP cord-274707-mxh38hwd 121 8 to to TO cord-274707-mxh38hwd 121 9 detect detect VB cord-274707-mxh38hwd 121 10 pathogen pathogen NN cord-274707-mxh38hwd 121 11 DNA dna NN cord-274707-mxh38hwd 121 12 , , , cord-274707-mxh38hwd 121 13 the the DT cord-274707-mxh38hwd 121 14 simplest simple JJS cord-274707-mxh38hwd 121 15 one one NN cord-274707-mxh38hwd 121 16 being be VBG cord-274707-mxh38hwd 121 17 specific specific JJ cord-274707-mxh38hwd 121 18 PCR PCR NNP cord-274707-mxh38hwd 121 19 where where WRB cord-274707-mxh38hwd 121 20 the the DT cord-274707-mxh38hwd 121 21 primers primer NNS cord-274707-mxh38hwd 121 22 are be VBP cord-274707-mxh38hwd 121 23 designed design VBN cord-274707-mxh38hwd 121 24 to to TO cord-274707-mxh38hwd 121 25 attach attach VB cord-274707-mxh38hwd 121 26 to to IN cord-274707-mxh38hwd 121 27 complementary complementary JJ cord-274707-mxh38hwd 121 28 regions region NNS cord-274707-mxh38hwd 121 29 of of IN cord-274707-mxh38hwd 121 30 a a DT cord-274707-mxh38hwd 121 31 DNA dna NN cord-274707-mxh38hwd 121 32 target target NN cord-274707-mxh38hwd 121 33 ( ( -LRB- cord-274707-mxh38hwd 121 34 specific specific JJ cord-274707-mxh38hwd 121 35 to to IN cord-274707-mxh38hwd 121 36 the the DT cord-274707-mxh38hwd 121 37 pathogen pathogen NN cord-274707-mxh38hwd 121 38 that that WDT cord-274707-mxh38hwd 121 39 is be VBZ cord-274707-mxh38hwd 121 40 being be VBG cord-274707-mxh38hwd 121 41 assayed assay VBN cord-274707-mxh38hwd 121 42 ) ) -RRB- cord-274707-mxh38hwd 121 43 . . . cord-274707-mxh38hwd 122 1 Broad broad JJ cord-274707-mxh38hwd 122 2 - - HYPH cord-274707-mxh38hwd 122 3 range range NN cord-274707-mxh38hwd 122 4 PCR PCR NNP cord-274707-mxh38hwd 122 5 attempt attempt NN cord-274707-mxh38hwd 122 6 to to TO cord-274707-mxh38hwd 122 7 detect detect VB cord-274707-mxh38hwd 122 8 a a DT cord-274707-mxh38hwd 122 9 broader broad JJR cord-274707-mxh38hwd 122 10 group group NN cord-274707-mxh38hwd 122 11 of of IN cord-274707-mxh38hwd 122 12 organisms organism NNS cord-274707-mxh38hwd 122 13 by by IN cord-274707-mxh38hwd 122 14 designing design VBG cord-274707-mxh38hwd 122 15 primers primer NNS cord-274707-mxh38hwd 122 16 that that WDT cord-274707-mxh38hwd 122 17 are be VBP cord-274707-mxh38hwd 122 18 complementary complementary JJ cord-274707-mxh38hwd 122 19 to to IN cord-274707-mxh38hwd 122 20 conserved conserved JJ cord-274707-mxh38hwd 122 21 regions region NNS cord-274707-mxh38hwd 122 22 of of IN cord-274707-mxh38hwd 122 23 a a DT cord-274707-mxh38hwd 122 24 particular particular JJ cord-274707-mxh38hwd 122 25 gene gene NN cord-274707-mxh38hwd 122 26 that that WDT cord-274707-mxh38hwd 122 27 are be VBP cord-274707-mxh38hwd 122 28 shared share VBN cord-274707-mxh38hwd 122 29 by by IN cord-274707-mxh38hwd 122 30 a a DT cord-274707-mxh38hwd 122 31 given give VBN cord-274707-mxh38hwd 122 32 taxonomic taxonomic JJ cord-274707-mxh38hwd 122 33 group group NN cord-274707-mxh38hwd 122 34 ( ( -LRB- cord-274707-mxh38hwd 122 35 Relman Relman NNP cord-274707-mxh38hwd 122 36 , , , cord-274707-mxh38hwd 122 37 1998 1998 CD cord-274707-mxh38hwd 122 38 ) ) -RRB- cord-274707-mxh38hwd 122 39 . . . cord-274707-mxh38hwd 123 1 Another another DT cord-274707-mxh38hwd 123 2 variation variation NN cord-274707-mxh38hwd 123 3 is be VBZ cord-274707-mxh38hwd 123 4 multiplexing multiplexe VBG cord-274707-mxh38hwd 123 5 , , , cord-274707-mxh38hwd 123 6 in in IN cord-274707-mxh38hwd 123 7 which which WDT cord-274707-mxh38hwd 123 8 multiple multiple JJ cord-274707-mxh38hwd 123 9 specific specific JJ cord-274707-mxh38hwd 123 10 PCR PCR NNP cord-274707-mxh38hwd 123 11 assays assay NNS cord-274707-mxh38hwd 123 12 are be VBP cord-274707-mxh38hwd 123 13 run run VBN cord-274707-mxh38hwd 123 14 simultaneously simultaneously RB cord-274707-mxh38hwd 123 15 in in IN cord-274707-mxh38hwd 123 16 the the DT cord-274707-mxh38hwd 123 17 same same JJ cord-274707-mxh38hwd 123 18 reaction reaction NN cord-274707-mxh38hwd 123 19 tube tube NN cord-274707-mxh38hwd 123 20 test test NN cord-274707-mxh38hwd 123 21 for for IN cord-274707-mxh38hwd 123 22 multiple multiple JJ cord-274707-mxh38hwd 123 23 different different JJ cord-274707-mxh38hwd 123 24 DNA dna NN cord-274707-mxh38hwd 123 25 templates template NNS cord-274707-mxh38hwd 123 26 . . . cord-274707-mxh38hwd 124 1 In in IN cord-274707-mxh38hwd 124 2 multiplex multiplex JJ cord-274707-mxh38hwd 124 3 PCR PCR NNP cord-274707-mxh38hwd 124 4 several several JJ cord-274707-mxh38hwd 124 5 sets set NNS cord-274707-mxh38hwd 124 6 of of IN cord-274707-mxh38hwd 124 7 primers primer NNS cord-274707-mxh38hwd 124 8 are be VBP cord-274707-mxh38hwd 124 9 added add VBN cord-274707-mxh38hwd 124 10 to to IN cord-274707-mxh38hwd 124 11 the the DT cord-274707-mxh38hwd 124 12 reaction reaction NN cord-274707-mxh38hwd 124 13 in in IN cord-274707-mxh38hwd 124 14 order order NN cord-274707-mxh38hwd 124 15 to to TO cord-274707-mxh38hwd 124 16 generate generate VB cord-274707-mxh38hwd 124 17 several several JJ cord-274707-mxh38hwd 124 18 different different JJ cord-274707-mxh38hwd 124 19 PCR PCR NNP cord-274707-mxh38hwd 124 20 products product NNS cord-274707-mxh38hwd 124 21 . . . cord-274707-mxh38hwd 125 1 In in IN cord-274707-mxh38hwd 125 2 this this DT cord-274707-mxh38hwd 125 3 case case NN cord-274707-mxh38hwd 125 4 postamplification postamplification NN cord-274707-mxh38hwd 125 5 methods method NNS cord-274707-mxh38hwd 125 6 are be VBP cord-274707-mxh38hwd 125 7 needed need VBN cord-274707-mxh38hwd 125 8 to to TO cord-274707-mxh38hwd 125 9 determine determine VB cord-274707-mxh38hwd 125 10 which which WDT cord-274707-mxh38hwd 125 11 organism organism NN cord-274707-mxh38hwd 125 12 is be VBZ cord-274707-mxh38hwd 125 13 represented represent VBN cord-274707-mxh38hwd 125 14 in in IN cord-274707-mxh38hwd 125 15 a a DT cord-274707-mxh38hwd 125 16 positive positive JJ cord-274707-mxh38hwd 125 17 reaction reaction NN cord-274707-mxh38hwd 125 18 ( ( -LRB- cord-274707-mxh38hwd 125 19 Fredricks Fredricks NNP cord-274707-mxh38hwd 125 20 & & CC cord-274707-mxh38hwd 125 21 Relman Relman NNP cord-274707-mxh38hwd 125 22 , , , cord-274707-mxh38hwd 125 23 1999 1999 CD cord-274707-mxh38hwd 125 24 ) ) -RRB- cord-274707-mxh38hwd 125 25 . . . cord-274707-mxh38hwd 126 1 PCR PCR NNP cord-274707-mxh38hwd 126 2 is be VBZ cord-274707-mxh38hwd 126 3 possibly possibly RB cord-274707-mxh38hwd 126 4 the the DT cord-274707-mxh38hwd 126 5 most most RBS cord-274707-mxh38hwd 126 6 quintessential quintessential JJ cord-274707-mxh38hwd 126 7 molecular molecular JJ cord-274707-mxh38hwd 126 8 method method NN cord-274707-mxh38hwd 126 9 yet yet RB cord-274707-mxh38hwd 126 10 developed develop VBN cord-274707-mxh38hwd 126 11 . . . cord-274707-mxh38hwd 127 1 Real real JJ cord-274707-mxh38hwd 127 2 - - HYPH cord-274707-mxh38hwd 127 3 time time NN cord-274707-mxh38hwd 127 4 quantitative quantitative JJ cord-274707-mxh38hwd 127 5 PCR PCR NNP cord-274707-mxh38hwd 127 6 ( ( -LRB- cord-274707-mxh38hwd 127 7 qPCR qPCR NNP cord-274707-mxh38hwd 127 8 ) ) -RRB- cord-274707-mxh38hwd 127 9 revolutionized revolutionize VBN cord-274707-mxh38hwd 127 10 clinical clinical JJ cord-274707-mxh38hwd 127 11 application application NN cord-274707-mxh38hwd 127 12 of of IN cord-274707-mxh38hwd 127 13 PCR PCR NNP cord-274707-mxh38hwd 127 14 partly partly RB cord-274707-mxh38hwd 127 15 because because IN cord-274707-mxh38hwd 127 16 it -PRON- PRP cord-274707-mxh38hwd 127 17 automated automate VBD cord-274707-mxh38hwd 127 18 analysis analysis NN cord-274707-mxh38hwd 127 19 by by IN cord-274707-mxh38hwd 127 20 removing remove VBG cord-274707-mxh38hwd 127 21 the the DT cord-274707-mxh38hwd 127 22 need need NN cord-274707-mxh38hwd 127 23 for for IN cord-274707-mxh38hwd 127 24 postreaction postreaction NN cord-274707-mxh38hwd 127 25 manipulation manipulation NN cord-274707-mxh38hwd 127 26 ( ( -LRB- cord-274707-mxh38hwd 127 27 Huggett Huggett NNP cord-274707-mxh38hwd 127 28 et et FW cord-274707-mxh38hwd 127 29 al al NNP cord-274707-mxh38hwd 127 30 . . NNP cord-274707-mxh38hwd 127 31 , , , cord-274707-mxh38hwd 127 32 2015 2015 CD cord-274707-mxh38hwd 127 33 ) ) -RRB- cord-274707-mxh38hwd 127 34 . . . cord-274707-mxh38hwd 128 1 qPCR qPCR NNP cord-274707-mxh38hwd 128 2 is be VBZ cord-274707-mxh38hwd 128 3 over over IN cord-274707-mxh38hwd 128 4 20 20 CD cord-274707-mxh38hwd 128 5 year year NN cord-274707-mxh38hwd 128 6 old old JJ cord-274707-mxh38hwd 129 1 ( ( -LRB- cord-274707-mxh38hwd 129 2 Higuchi Higuchi NNP cord-274707-mxh38hwd 129 3 et et NNP cord-274707-mxh38hwd 129 4 al al NNP cord-274707-mxh38hwd 129 5 . . NNP cord-274707-mxh38hwd 129 6 , , , cord-274707-mxh38hwd 129 7 1992 1992 CD cord-274707-mxh38hwd 129 8 ) ) -RRB- cord-274707-mxh38hwd 129 9 , , . cord-274707-mxh38hwd 130 1 but but CC cord-274707-mxh38hwd 130 2 it -PRON- PRP cord-274707-mxh38hwd 130 3 has have VBZ cord-274707-mxh38hwd 130 4 only only RB cord-274707-mxh38hwd 130 5 really really RB cord-274707-mxh38hwd 130 6 been be VBN cord-274707-mxh38hwd 130 7 applied apply VBN cord-274707-mxh38hwd 130 8 clinically clinically RB cord-274707-mxh38hwd 130 9 in in IN cord-274707-mxh38hwd 130 10 areas area NNS cord-274707-mxh38hwd 130 11 which which WDT cord-274707-mxh38hwd 130 12 alternatives alternative NNS cord-274707-mxh38hwd 130 13 are be VBP cord-274707-mxh38hwd 130 14 not not RB cord-274707-mxh38hwd 130 15 practically practically RB cord-274707-mxh38hwd 130 16 possible possible JJ cord-274707-mxh38hwd 130 17 , , , cord-274707-mxh38hwd 130 18 such such JJ cord-274707-mxh38hwd 130 19 as as IN cord-274707-mxh38hwd 130 20 monitoring monitor VBG cord-274707-mxh38hwd 130 21 treatment treatment NN cord-274707-mxh38hwd 130 22 in in IN cord-274707-mxh38hwd 130 23 diseases disease NNS cord-274707-mxh38hwd 130 24 like like IN cord-274707-mxh38hwd 130 25 chronic chronic NN cord-274707-mxh38hwd 130 26 - - HYPH cord-274707-mxh38hwd 130 27 phase phase NN cord-274707-mxh38hwd 130 28 chronic chronic JJ cord-274707-mxh38hwd 130 29 myeloid myeloid NN cord-274707-mxh38hwd 130 30 leukaemia leukaemia NN cord-274707-mxh38hwd 130 31 ( ( -LRB- cord-274707-mxh38hwd 130 32 Cross Cross NNP cord-274707-mxh38hwd 130 33 et et FW cord-274707-mxh38hwd 130 34 al al NNP cord-274707-mxh38hwd 130 35 . . NNP cord-274707-mxh38hwd 130 36 , , , cord-274707-mxh38hwd 130 37 2012 2012 CD cord-274707-mxh38hwd 130 38 ) ) -RRB- cord-274707-mxh38hwd 130 39 or or CC cord-274707-mxh38hwd 130 40 for for IN cord-274707-mxh38hwd 130 41 some some DT cord-274707-mxh38hwd 130 42 key key JJ cord-274707-mxh38hwd 130 43 blood blood NN cord-274707-mxh38hwd 130 44 borne bear VBN cord-274707-mxh38hwd 130 45 viruses virus NNS cord-274707-mxh38hwd 130 46 ( ( -LRB- cord-274707-mxh38hwd 130 47 Fryer Fryer NNP cord-274707-mxh38hwd 130 48 et et NNP cord-274707-mxh38hwd 130 49 al al NNP cord-274707-mxh38hwd 130 50 . . NNP cord-274707-mxh38hwd 130 51 , , , cord-274707-mxh38hwd 131 1 2008 2008 CD cord-274707-mxh38hwd 131 2 Three three CD cord-274707-mxh38hwd 131 3 tests test NNS cord-274707-mxh38hwd 131 4 use use VBP cord-274707-mxh38hwd 131 5 RT RT NNP cord-274707-mxh38hwd 131 6 - - HYPH cord-274707-mxh38hwd 131 7 PCR PCR NNP cord-274707-mxh38hwd 131 8 as as IN cord-274707-mxh38hwd 131 9 the the DT cord-274707-mxh38hwd 131 10 core core NN cord-274707-mxh38hwd 131 11 technology technology NN cord-274707-mxh38hwd 131 12 to to TO cord-274707-mxh38hwd 131 13 detect detect VB cord-274707-mxh38hwd 131 14 SARS SARS NNP cord-274707-mxh38hwd 131 15 - - HYPH cord-274707-mxh38hwd 131 16 CoV-2 CoV-2 NNP cord-274707-mxh38hwd 131 17 in in IN cord-274707-mxh38hwd 131 18 samples sample NNS cord-274707-mxh38hwd 131 19 of of IN cord-274707-mxh38hwd 131 20 the the DT cord-274707-mxh38hwd 131 21 airways airway NNS cord-274707-mxh38hwd 131 22 of of IN cord-274707-mxh38hwd 131 23 the the DT cord-274707-mxh38hwd 131 24 patients patient NNS cord-274707-mxh38hwd 131 25 , , , cord-274707-mxh38hwd 131 26 targeting target VBG cord-274707-mxh38hwd 131 27 the the DT cord-274707-mxh38hwd 131 28 conserved conserve VBN cord-274707-mxh38hwd 131 29 genes gene NNS cord-274707-mxh38hwd 131 30 ORF1ab ORF1ab NNP cord-274707-mxh38hwd 131 31 and and CC cord-274707-mxh38hwd 131 32 N. N. NNP cord-274707-mxh38hwd 131 33 Probes Probes NNPS cord-274707-mxh38hwd 131 34 with with IN cord-274707-mxh38hwd 131 35 fluorescent fluorescent JJ cord-274707-mxh38hwd 131 36 reporter reporter NN cord-274707-mxh38hwd 131 37 dye dye NN cord-274707-mxh38hwd 131 38 are be VBP cord-274707-mxh38hwd 131 39 used use VBN cord-274707-mxh38hwd 131 40 to to TO cord-274707-mxh38hwd 131 41 make make VB cord-274707-mxh38hwd 131 42 the the DT cord-274707-mxh38hwd 131 43 detection detection NN cord-274707-mxh38hwd 131 44 . . . cord-274707-mxh38hwd 132 1 Positive positive JJ cord-274707-mxh38hwd 132 2 results result NNS cord-274707-mxh38hwd 132 3 are be VBP cord-274707-mxh38hwd 132 4 indicative indicative JJ cord-274707-mxh38hwd 132 5 of of IN cord-274707-mxh38hwd 132 6 the the DT cord-274707-mxh38hwd 132 7 presence presence NN cord-274707-mxh38hwd 132 8 of of IN cord-274707-mxh38hwd 132 9 RNA RNA NNP cord-274707-mxh38hwd 132 10 of of IN cord-274707-mxh38hwd 132 11 the the DT cord-274707-mxh38hwd 132 12 virus virus NN cord-274707-mxh38hwd 132 13 , , , cord-274707-mxh38hwd 132 14 but but CC cord-274707-mxh38hwd 132 15 a a DT cord-274707-mxh38hwd 132 16 clinical clinical JJ cord-274707-mxh38hwd 132 17 correlation correlation NN cord-274707-mxh38hwd 132 18 with with IN cord-274707-mxh38hwd 132 19 patient´s patient´s NNP cord-274707-mxh38hwd 132 20 history history NN cord-274707-mxh38hwd 132 21 is be VBZ cord-274707-mxh38hwd 132 22 necessary necessary JJ cord-274707-mxh38hwd 132 23 . . . cord-274707-mxh38hwd 133 1 Tests test NNS cord-274707-mxh38hwd 133 2 are be VBP cord-274707-mxh38hwd 133 3 highly highly RB cord-274707-mxh38hwd 133 4 sensitive sensitive JJ cord-274707-mxh38hwd 133 5 . . . cord-274707-mxh38hwd 134 1 These these DT cord-274707-mxh38hwd 134 2 data datum NNS cord-274707-mxh38hwd 134 3 were be VBD cord-274707-mxh38hwd 134 4 provided provide VBN cord-274707-mxh38hwd 134 5 by by IN cord-274707-mxh38hwd 134 6 Secretaria Secretaria NNP cord-274707-mxh38hwd 134 7 de de NNP cord-274707-mxh38hwd 134 8 Ciência Ciência NNP cord-274707-mxh38hwd 134 9 , , , cord-274707-mxh38hwd 134 10 Tecnologia Tecnologia NNP cord-274707-mxh38hwd 134 11 , , , cord-274707-mxh38hwd 134 12 Inovação Inovação NNP cord-274707-mxh38hwd 134 13 e e NNP cord-274707-mxh38hwd 134 14 Insumos Insumos NNP cord-274707-mxh38hwd 134 15 Estratégicos Estratégicos NNP cord-274707-mxh38hwd 134 16 em -PRON- NNP cord-274707-mxh38hwd 134 17 Saúde Saúde NNP cord-274707-mxh38hwd 134 18 -SCTIE -SCTIE . cord-274707-mxh38hwd 135 1 ( ( -LRB- cord-274707-mxh38hwd 135 2 2020 2020 CD cord-274707-mxh38hwd 135 3 ) ) -RRB- cord-274707-mxh38hwd 135 4 . . . cord-274707-mxh38hwd 136 1 On on IN cord-274707-mxh38hwd 136 2 2 2 CD cord-274707-mxh38hwd 136 3 March March NNP cord-274707-mxh38hwd 136 4 2020 2020 CD cord-274707-mxh38hwd 136 5 , , , cord-274707-mxh38hwd 136 6 WHO who WP cord-274707-mxh38hwd 136 7 released release VBD cord-274707-mxh38hwd 136 8 an an DT cord-274707-mxh38hwd 136 9 interim interim JJ cord-274707-mxh38hwd 136 10 guidance guidance NN cord-274707-mxh38hwd 136 11 regarding regard VBG cord-274707-mxh38hwd 136 12 laboratory laboratory NN cord-274707-mxh38hwd 136 13 testing testing NN cord-274707-mxh38hwd 136 14 for for IN cord-274707-mxh38hwd 136 15 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 136 16 in in IN cord-274707-mxh38hwd 136 17 suspected suspect VBN cord-274707-mxh38hwd 136 18 human human JJ cord-274707-mxh38hwd 136 19 cases case NNS cord-274707-mxh38hwd 136 20 recommending recommend VBG cord-274707-mxh38hwd 136 21 that that IN cord-274707-mxh38hwd 136 22 tests test NNS cord-274707-mxh38hwd 136 23 should should MD cord-274707-mxh38hwd 136 24 be be VB cord-274707-mxh38hwd 136 25 based base VBN cord-274707-mxh38hwd 136 26 on on IN cord-274707-mxh38hwd 136 27 clinical clinical JJ cord-274707-mxh38hwd 136 28 and and CC cord-274707-mxh38hwd 136 29 epidemiological epidemiological JJ cord-274707-mxh38hwd 136 30 factor factor NN cord-274707-mxh38hwd 136 31 and and CC cord-274707-mxh38hwd 136 32 linked link VBN cord-274707-mxh38hwd 136 33 to to IN cord-274707-mxh38hwd 136 34 assessment assessment NN cord-274707-mxh38hwd 136 35 of of IN cord-274707-mxh38hwd 136 36 the the DT cord-274707-mxh38hwd 136 37 likelihood likelihood NN cord-274707-mxh38hwd 136 38 of of IN cord-274707-mxh38hwd 136 39 infection infection NN cord-274707-mxh38hwd 136 40 . . . cord-274707-mxh38hwd 137 1 But but CC cord-274707-mxh38hwd 137 2 is be VBZ cord-274707-mxh38hwd 137 3 also also RB cord-274707-mxh38hwd 137 4 recommended recommend VBN cord-274707-mxh38hwd 137 5 PCR PCR NNP cord-274707-mxh38hwd 137 6 testing testing NN cord-274707-mxh38hwd 137 7 of of IN cord-274707-mxh38hwd 137 8 asymptomatic asymptomatic JJ cord-274707-mxh38hwd 137 9 or or CC cord-274707-mxh38hwd 137 10 mildly mildly RB cord-274707-mxh38hwd 137 11 symptomatic symptomatic JJ cord-274707-mxh38hwd 137 12 cases case NNS cord-274707-mxh38hwd 137 13 ( ( -LRB- cord-274707-mxh38hwd 137 14 WHO who WP cord-274707-mxh38hwd 137 15 , , , cord-274707-mxh38hwd 137 16 2020b 2020b CD cord-274707-mxh38hwd 137 17 ) ) -RRB- cord-274707-mxh38hwd 137 18 . . . cord-274707-mxh38hwd 138 1 We -PRON- PRP cord-274707-mxh38hwd 138 2 should should MD cord-274707-mxh38hwd 138 3 keep keep VB cord-274707-mxh38hwd 138 4 in in IN cord-274707-mxh38hwd 138 5 mind mind NN cord-274707-mxh38hwd 138 6 that that IN cord-274707-mxh38hwd 138 7 the the DT cord-274707-mxh38hwd 138 8 gold gold NN cord-274707-mxh38hwd 138 9 standard standard NN cord-274707-mxh38hwd 138 10 for for IN cord-274707-mxh38hwd 138 11 diagnosing diagnose VBG cord-274707-mxh38hwd 138 12 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 138 13 , , , cord-274707-mxh38hwd 138 14 as as IN cord-274707-mxh38hwd 138 15 referred refer VBN cord-274707-mxh38hwd 138 16 by by IN cord-274707-mxh38hwd 138 17 WHO WHO NNP cord-274707-mxh38hwd 138 18 , , , cord-274707-mxh38hwd 138 19 are be VBP cord-274707-mxh38hwd 138 20 nucleic nucleic JJ cord-274707-mxh38hwd 138 21 acid acid NN cord-274707-mxh38hwd 138 22 amplification amplification NN cord-274707-mxh38hwd 138 23 tests test NNS cord-274707-mxh38hwd 138 24 ( ( -LRB- cord-274707-mxh38hwd 138 25 NAAT NAAT NNP cord-274707-mxh38hwd 138 26 ) ) -RRB- cord-274707-mxh38hwd 138 27 such such JJ cord-274707-mxh38hwd 138 28 as as IN cord-274707-mxh38hwd 138 29 RT RT NNP cord-274707-mxh38hwd 138 30 - - HYPH cord-274707-mxh38hwd 138 31 PCR PCR NNP cord-274707-mxh38hwd 138 32 , , , cord-274707-mxh38hwd 138 33 followed follow VBN cord-274707-mxh38hwd 138 34 by by IN cord-274707-mxh38hwd 138 35 nucleic nucleic JJ cord-274707-mxh38hwd 138 36 acid acid NN cord-274707-mxh38hwd 138 37 sequencing sequencing NN cord-274707-mxh38hwd 138 38 when when WRB cord-274707-mxh38hwd 138 39 necessary necessary JJ cord-274707-mxh38hwd 138 40 . . . cord-274707-mxh38hwd 139 1 The the DT cord-274707-mxh38hwd 139 2 viral viral JJ cord-274707-mxh38hwd 139 3 genes gene NNS cord-274707-mxh38hwd 139 4 targeted target VBN cord-274707-mxh38hwd 139 5 so so RB cord-274707-mxh38hwd 139 6 far far RB cord-274707-mxh38hwd 139 7 include include VBP cord-274707-mxh38hwd 139 8 the the DT cord-274707-mxh38hwd 139 9 N n NN cord-274707-mxh38hwd 139 10 , , , cord-274707-mxh38hwd 139 11 E E NNP cord-274707-mxh38hwd 139 12 , , , cord-274707-mxh38hwd 139 13 S S NNP cord-274707-mxh38hwd 139 14 and and CC cord-274707-mxh38hwd 139 15 RdRP rdrp NN cord-274707-mxh38hwd 139 16 genes gene NNS cord-274707-mxh38hwd 139 17 ( ( -LRB- cord-274707-mxh38hwd 139 18 WHO who WP cord-274707-mxh38hwd 139 19 , , , cord-274707-mxh38hwd 139 20 2020b 2020b CD cord-274707-mxh38hwd 139 21 ) ) -RRB- cord-274707-mxh38hwd 139 22 . . . cord-274707-mxh38hwd 140 1 Serological serological JJ cord-274707-mxh38hwd 140 2 testing testing NN cord-274707-mxh38hwd 140 3 can can MD cord-274707-mxh38hwd 140 4 aid aid VB cord-274707-mxh38hwd 140 5 investigation investigation NN cord-274707-mxh38hwd 140 6 of of IN cord-274707-mxh38hwd 140 7 an an DT cord-274707-mxh38hwd 140 8 ongoing ongoing JJ cord-274707-mxh38hwd 140 9 outbreak outbreak NN cord-274707-mxh38hwd 140 10 and and CC cord-274707-mxh38hwd 140 11 retrospective retrospective JJ cord-274707-mxh38hwd 140 12 assessment assessment NN cord-274707-mxh38hwd 140 13 of of IN cord-274707-mxh38hwd 140 14 the the DT cord-274707-mxh38hwd 140 15 attack attack NN cord-274707-mxh38hwd 140 16 rate rate NN cord-274707-mxh38hwd 140 17 or or CC cord-274707-mxh38hwd 140 18 extent extent NN cord-274707-mxh38hwd 140 19 of of IN cord-274707-mxh38hwd 140 20 an an DT cord-274707-mxh38hwd 140 21 outbreak outbreak NN cord-274707-mxh38hwd 140 22 . . . cord-274707-mxh38hwd 141 1 In in IN cord-274707-mxh38hwd 141 2 cases case NNS cord-274707-mxh38hwd 141 3 were be VBD cord-274707-mxh38hwd 141 4 NAAT NAAT NNP cord-274707-mxh38hwd 141 5 assays assay NNS cord-274707-mxh38hwd 141 6 are be VBP cord-274707-mxh38hwd 141 7 negative negative JJ cord-274707-mxh38hwd 141 8 and and CC cord-274707-mxh38hwd 141 9 there there EX cord-274707-mxh38hwd 141 10 is be VBZ cord-274707-mxh38hwd 141 11 a a DT cord-274707-mxh38hwd 141 12 strong strong JJ cord-274707-mxh38hwd 141 13 epidemiological epidemiological JJ cord-274707-mxh38hwd 141 14 link link NN cord-274707-mxh38hwd 141 15 to to IN cord-274707-mxh38hwd 141 16 COVID-19 covid-19 JJ cord-274707-mxh38hwd 141 17 infection infection NN cord-274707-mxh38hwd 141 18 , , , cord-274707-mxh38hwd 141 19 paired pair VBN cord-274707-mxh38hwd 141 20 serum serum NN cord-274707-mxh38hwd 141 21 samples sample NNS cord-274707-mxh38hwd 141 22 ( ( -LRB- cord-274707-mxh38hwd 141 23 in in IN cord-274707-mxh38hwd 141 24 the the DT cord-274707-mxh38hwd 141 25 acute acute JJ cord-274707-mxh38hwd 141 26 and and CC cord-274707-mxh38hwd 141 27 convalescent convalescent JJ cord-274707-mxh38hwd 141 28 phase phase NN cord-274707-mxh38hwd 141 29 ) ) -RRB- cord-274707-mxh38hwd 141 30 could could MD cord-274707-mxh38hwd 141 31 support support VB cord-274707-mxh38hwd 141 32 diagnosis diagnosis NN cord-274707-mxh38hwd 141 33 once once RB cord-274707-mxh38hwd 141 34 validated validate VBD cord-274707-mxh38hwd 141 35 serology serology NN cord-274707-mxh38hwd 141 36 tests test NNS cord-274707-mxh38hwd 141 37 are be VBP cord-274707-mxh38hwd 141 38 available available JJ cord-274707-mxh38hwd 141 39 ( ( -LRB- cord-274707-mxh38hwd 141 40 WHO who WP cord-274707-mxh38hwd 141 41 , , , cord-274707-mxh38hwd 141 42 2020b 2020b CD cord-274707-mxh38hwd 141 43 ) ) -RRB- cord-274707-mxh38hwd 141 44 . . . cord-274707-mxh38hwd 142 1 It -PRON- PRP cord-274707-mxh38hwd 142 2 is be VBZ cord-274707-mxh38hwd 142 3 widely widely RB cord-274707-mxh38hwd 142 4 accepted accept VBN cord-274707-mxh38hwd 142 5 that that IN cord-274707-mxh38hwd 142 6 IgM IgM NNP cord-274707-mxh38hwd 142 7 provides provide VBZ cord-274707-mxh38hwd 142 8 the the DT cord-274707-mxh38hwd 142 9 first first JJ cord-274707-mxh38hwd 142 10 line line NN cord-274707-mxh38hwd 142 11 of of IN cord-274707-mxh38hwd 142 12 defence defence NN cord-274707-mxh38hwd 142 13 during during IN cord-274707-mxh38hwd 142 14 viral viral JJ cord-274707-mxh38hwd 142 15 infections infection NNS cord-274707-mxh38hwd 142 16 , , , cord-274707-mxh38hwd 142 17 prior prior RB cord-274707-mxh38hwd 142 18 to to IN cord-274707-mxh38hwd 142 19 the the DT cord-274707-mxh38hwd 142 20 generation generation NN cord-274707-mxh38hwd 142 21 of of IN cord-274707-mxh38hwd 142 22 adaptive adaptive JJ cord-274707-mxh38hwd 142 23 , , , cord-274707-mxh38hwd 142 24 high high JJ cord-274707-mxh38hwd 142 25 affinity affinity NN cord-274707-mxh38hwd 142 26 IgG igg NN cord-274707-mxh38hwd 142 27 responses response NNS cord-274707-mxh38hwd 142 28 , , , cord-274707-mxh38hwd 142 29 that that WDT cord-274707-mxh38hwd 142 30 are be VBP cord-274707-mxh38hwd 142 31 important important JJ cord-274707-mxh38hwd 142 32 for for IN cord-274707-mxh38hwd 142 33 long long JJ cord-274707-mxh38hwd 142 34 term term NN cord-274707-mxh38hwd 142 35 immunity immunity NN cord-274707-mxh38hwd 142 36 and and CC cord-274707-mxh38hwd 142 37 immunological immunological JJ cord-274707-mxh38hwd 142 38 memory memory NN cord-274707-mxh38hwd 142 39 ( ( -LRB- cord-274707-mxh38hwd 142 40 Racine Racine NNP cord-274707-mxh38hwd 142 41 & & CC cord-274707-mxh38hwd 142 42 Winslow Winslow NNP cord-274707-mxh38hwd 142 43 , , , cord-274707-mxh38hwd 142 44 2009 2009 CD cord-274707-mxh38hwd 142 45 ) ) -RRB- cord-274707-mxh38hwd 142 46 . . . cord-274707-mxh38hwd 143 1 It -PRON- PRP cord-274707-mxh38hwd 143 2 was be VBD cord-274707-mxh38hwd 143 3 reported report VBN cord-274707-mxh38hwd 143 4 that that IN cord-274707-mxh38hwd 143 5 after after IN cord-274707-mxh38hwd 143 6 SARS SARS NNP cord-274707-mxh38hwd 143 7 infection infection NN cord-274707-mxh38hwd 143 8 , , , cord-274707-mxh38hwd 143 9 IgM IgM NNP cord-274707-mxh38hwd 143 10 antibody antibody NN cord-274707-mxh38hwd 143 11 could could MD cord-274707-mxh38hwd 143 12 be be VB cord-274707-mxh38hwd 143 13 detected detect VBN cord-274707-mxh38hwd 143 14 in in IN cord-274707-mxh38hwd 143 15 patient patient JJ cord-274707-mxh38hwd 143 16 blood blood NN cord-274707-mxh38hwd 143 17 after after IN cord-274707-mxh38hwd 143 18 3 3 CD cord-274707-mxh38hwd 143 19 - - SYM cord-274707-mxh38hwd 143 20 6 6 CD cord-274707-mxh38hwd 143 21 days day NNS cord-274707-mxh38hwd 143 22 and and CC cord-274707-mxh38hwd 143 23 IgG igg NN cord-274707-mxh38hwd 143 24 after after IN cord-274707-mxh38hwd 143 25 8 8 CD cord-274707-mxh38hwd 143 26 days day NNS cord-274707-mxh38hwd 143 27 ( ( -LRB- cord-274707-mxh38hwd 143 28 Lee Lee NNP cord-274707-mxh38hwd 143 29 et et NNP cord-274707-mxh38hwd 143 30 al al NNP cord-274707-mxh38hwd 143 31 . . NNP cord-274707-mxh38hwd 143 32 , , , cord-274707-mxh38hwd 143 33 2010 2010 CD cord-274707-mxh38hwd 143 34 ) ) -RRB- cord-274707-mxh38hwd 143 35 . . . cord-274707-mxh38hwd 144 1 Since since IN cord-274707-mxh38hwd 144 2 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 144 3 belongs belong VBZ cord-274707-mxh38hwd 144 4 to to IN cord-274707-mxh38hwd 144 5 the the DT cord-274707-mxh38hwd 144 6 same same JJ cord-274707-mxh38hwd 144 7 family family NN cord-274707-mxh38hwd 144 8 of of IN cord-274707-mxh38hwd 144 9 viruses virus NNS cord-274707-mxh38hwd 144 10 as as IN cord-274707-mxh38hwd 144 11 those those DT cord-274707-mxh38hwd 144 12 that that WDT cord-274707-mxh38hwd 144 13 caused cause VBD cord-274707-mxh38hwd 144 14 MERS MERS NNP cord-274707-mxh38hwd 144 15 and and CC cord-274707-mxh38hwd 144 16 SARS SARS NNP cord-274707-mxh38hwd 144 17 outbreaks outbreak NNS cord-274707-mxh38hwd 144 18 it -PRON- PRP cord-274707-mxh38hwd 144 19 is be VBZ cord-274707-mxh38hwd 144 20 reasonable reasonable JJ cord-274707-mxh38hwd 144 21 to to TO cord-274707-mxh38hwd 144 22 infer infer VB cord-274707-mxh38hwd 144 23 that that IN cord-274707-mxh38hwd 144 24 its -PRON- PRP$ cord-274707-mxh38hwd 144 25 antibody antibody NN cord-274707-mxh38hwd 144 26 generation generation NN cord-274707-mxh38hwd 144 27 process process NN cord-274707-mxh38hwd 144 28 is be VBZ cord-274707-mxh38hwd 144 29 similar similar JJ cord-274707-mxh38hwd 144 30 , , , cord-274707-mxh38hwd 144 31 and and CC cord-274707-mxh38hwd 144 32 detection detection NN cord-274707-mxh38hwd 144 33 of of IN cord-274707-mxh38hwd 144 34 the the DT cord-274707-mxh38hwd 144 35 IgG IgG NNP cord-274707-mxh38hwd 144 36 and and CC cord-274707-mxh38hwd 144 37 IgM IgM NNP cord-274707-mxh38hwd 144 38 antibody antibody NN cord-274707-mxh38hwd 144 39 against against IN cord-274707-mxh38hwd 144 40 SASR SASR NNP cord-274707-mxh38hwd 144 41 - - HYPH cord-274707-mxh38hwd 144 42 CoV-2 CoV-2 NNP cord-274707-mxh38hwd 144 43 will will MD cord-274707-mxh38hwd 144 44 be be VB cord-274707-mxh38hwd 144 45 an an DT cord-274707-mxh38hwd 144 46 indicator indicator NN cord-274707-mxh38hwd 144 47 of of IN cord-274707-mxh38hwd 144 48 infection infection NN cord-274707-mxh38hwd 144 49 ( ( -LRB- cord-274707-mxh38hwd 144 50 Li Li NNP cord-274707-mxh38hwd 144 51 et et NNP cord-274707-mxh38hwd 144 52 al al NNP cord-274707-mxh38hwd 144 53 . . NNP cord-274707-mxh38hwd 144 54 , , , cord-274707-mxh38hwd 144 55 2020b 2020b CD cord-274707-mxh38hwd 144 56 ) ) -RRB- cord-274707-mxh38hwd 144 57 . . . cord-274707-mxh38hwd 145 1 Cross cross NN cord-274707-mxh38hwd 145 2 reactivity reactivity NN cord-274707-mxh38hwd 145 3 to to IN cord-274707-mxh38hwd 145 4 other other JJ cord-274707-mxh38hwd 145 5 coronaviruses coronaviruse NNS cord-274707-mxh38hwd 145 6 can can MD cord-274707-mxh38hwd 145 7 be be VB cord-274707-mxh38hwd 145 8 challenging challenging JJ cord-274707-mxh38hwd 145 9 but but CC cord-274707-mxh38hwd 145 10 commercial commercial JJ cord-274707-mxh38hwd 145 11 and and CC cord-274707-mxh38hwd 145 12 non non JJ cord-274707-mxh38hwd 145 13 - - JJ cord-274707-mxh38hwd 145 14 commercial commercial JJ cord-274707-mxh38hwd 145 15 serological serological JJ cord-274707-mxh38hwd 145 16 tests test NNS cord-274707-mxh38hwd 145 17 are be VBP cord-274707-mxh38hwd 145 18 currently currently RB cord-274707-mxh38hwd 145 19 under under IN cord-274707-mxh38hwd 145 20 development development NN cord-274707-mxh38hwd 146 1 ( ( -LRB- cord-274707-mxh38hwd 146 2 Meyer Meyer NNP cord-274707-mxh38hwd 146 3 et et NNP cord-274707-mxh38hwd 146 4 al al NNP cord-274707-mxh38hwd 146 5 . . . cord-274707-mxh38hwd 147 1 , , , cord-274707-mxh38hwd 147 2 2014 2014 CD cord-274707-mxh38hwd 147 3 ) ) -RRB- cord-274707-mxh38hwd 147 4 . . . cord-274707-mxh38hwd 148 1 Some some DT cord-274707-mxh38hwd 148 2 studies study NNS cord-274707-mxh38hwd 148 3 with with IN cord-274707-mxh38hwd 148 4 COVID-19 covid-19 JJ cord-274707-mxh38hwd 148 5 serological serological JJ cord-274707-mxh38hwd 148 6 data datum NNS cord-274707-mxh38hwd 148 7 on on IN cord-274707-mxh38hwd 148 8 clinical clinical JJ cord-274707-mxh38hwd 148 9 samples sample NNS cord-274707-mxh38hwd 148 10 have have VBP cord-274707-mxh38hwd 148 11 been be VBN cord-274707-mxh38hwd 148 12 published publish VBN cord-274707-mxh38hwd 148 13 and and CC cord-274707-mxh38hwd 148 14 could could MD cord-274707-mxh38hwd 148 15 help help VB cord-274707-mxh38hwd 148 16 in in IN cord-274707-mxh38hwd 148 17 the the DT cord-274707-mxh38hwd 148 18 development development NN cord-274707-mxh38hwd 148 19 of of IN cord-274707-mxh38hwd 148 20 future future JJ cord-274707-mxh38hwd 148 21 tests test NNS cord-274707-mxh38hwd 148 22 . . . cord-274707-mxh38hwd 149 1 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 149 2 is be VBZ cord-274707-mxh38hwd 149 3 a a DT cord-274707-mxh38hwd 149 4 novel novel JJ cord-274707-mxh38hwd 149 5 disease disease NN cord-274707-mxh38hwd 149 6 caused cause VBN cord-274707-mxh38hwd 149 7 by by IN cord-274707-mxh38hwd 149 8 a a DT cord-274707-mxh38hwd 149 9 novel novel JJ cord-274707-mxh38hwd 149 10 coronavirus coronavirus NN cord-274707-mxh38hwd 149 11 ( ( -LRB- cord-274707-mxh38hwd 149 12 SARS SARS NNP cord-274707-mxh38hwd 149 13 - - HYPH cord-274707-mxh38hwd 149 14 CoV-2 CoV-2 NNP cord-274707-mxh38hwd 149 15 ) ) -RRB- cord-274707-mxh38hwd 149 16 that that WDT cord-274707-mxh38hwd 149 17 emerged emerge VBD cord-274707-mxh38hwd 149 18 in in IN cord-274707-mxh38hwd 149 19 2019 2019 CD cord-274707-mxh38hwd 149 20 that that WDT cord-274707-mxh38hwd 149 21 is be VBZ cord-274707-mxh38hwd 149 22 challenging challenge VBG cord-274707-mxh38hwd 149 23 scientists scientist NNS cord-274707-mxh38hwd 149 24 all all RB cord-274707-mxh38hwd 149 25 over over IN cord-274707-mxh38hwd 149 26 the the DT cord-274707-mxh38hwd 149 27 world world NN cord-274707-mxh38hwd 149 28 since since IN cord-274707-mxh38hwd 149 29 its -PRON- PRP$ cord-274707-mxh38hwd 149 30 appearance appearance NN cord-274707-mxh38hwd 149 31 . . . cord-274707-mxh38hwd 150 1 It -PRON- PRP cord-274707-mxh38hwd 150 2 is be VBZ cord-274707-mxh38hwd 150 3 not not RB cord-274707-mxh38hwd 150 4 , , , cord-274707-mxh38hwd 150 5 however however RB cord-274707-mxh38hwd 150 6 , , , cord-274707-mxh38hwd 150 7 the the DT cord-274707-mxh38hwd 150 8 first first JJ cord-274707-mxh38hwd 150 9 time time NN cord-274707-mxh38hwd 150 10 that that WDT cord-274707-mxh38hwd 150 11 coronaviruses coronaviruse NNS cord-274707-mxh38hwd 150 12 are be VBP cord-274707-mxh38hwd 150 13 responsible responsible JJ cord-274707-mxh38hwd 150 14 for for IN cord-274707-mxh38hwd 150 15 outbreaks outbreak NNS cord-274707-mxh38hwd 150 16 of of IN cord-274707-mxh38hwd 150 17 major major JJ cord-274707-mxh38hwd 150 18 importance importance NN cord-274707-mxh38hwd 150 19 : : : cord-274707-mxh38hwd 150 20 SARS SARS NNP cord-274707-mxh38hwd 150 21 ( ( -LRB- cord-274707-mxh38hwd 150 22 China China NNP cord-274707-mxh38hwd 150 23 , , , cord-274707-mxh38hwd 150 24 2002 2002 CD cord-274707-mxh38hwd 150 25 ( ( -LRB- cord-274707-mxh38hwd 150 26 China China NNP cord-274707-mxh38hwd 150 27 , , , cord-274707-mxh38hwd 150 28 -2003 -2003 , cord-274707-mxh38hwd 150 29 and and CC cord-274707-mxh38hwd 150 30 MERS MERS NNP cord-274707-mxh38hwd 150 31 ( ( -LRB- cord-274707-mxh38hwd 150 32 Saudi Saudi NNP cord-274707-mxh38hwd 150 33 Arabia Arabia NNP cord-274707-mxh38hwd 150 34 , , , cord-274707-mxh38hwd 150 35 2012-ongoing 2012-ongoing CD cord-274707-mxh38hwd 150 36 ) ) -RRB- cord-274707-mxh38hwd 150 37 were be VBD cord-274707-mxh38hwd 150 38 both both DT cord-274707-mxh38hwd 150 39 caused cause VBN cord-274707-mxh38hwd 150 40 by by IN cord-274707-mxh38hwd 150 41 coronavirus coronavirus NN cord-274707-mxh38hwd 150 42 . . . cord-274707-mxh38hwd 151 1 SARS SARS NNP cord-274707-mxh38hwd 151 2 had have VBD cord-274707-mxh38hwd 151 3 an an DT cord-274707-mxh38hwd 151 4 overall overall JJ cord-274707-mxh38hwd 151 5 case case NN cord-274707-mxh38hwd 151 6 fatality fatality NN cord-274707-mxh38hwd 151 7 rate rate NN cord-274707-mxh38hwd 151 8 ( ( -LRB- cord-274707-mxh38hwd 151 9 CFR CFR NNP cord-274707-mxh38hwd 151 10 ) ) -RRB- cord-274707-mxh38hwd 151 11 of of IN cord-274707-mxh38hwd 151 12 9.6 9.6 CD cord-274707-mxh38hwd 151 13 % % NN cord-274707-mxh38hwd 151 14 while while IN cord-274707-mxh38hwd 151 15 MERS MERS NNP cord-274707-mxh38hwd 151 16 presents present VBZ cord-274707-mxh38hwd 151 17 a a DT cord-274707-mxh38hwd 151 18 CFR CFR NNP cord-274707-mxh38hwd 151 19 of of IN cord-274707-mxh38hwd 151 20 34.4 34.4 CD cord-274707-mxh38hwd 151 21 % % NN cord-274707-mxh38hwd 151 22 . . . cord-274707-mxh38hwd 152 1 So so RB cord-274707-mxh38hwd 152 2 far far RB cord-274707-mxh38hwd 152 3 , , , cord-274707-mxh38hwd 152 4 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 152 5 presents present VBZ cord-274707-mxh38hwd 152 6 a a DT cord-274707-mxh38hwd 152 7 current current JJ cord-274707-mxh38hwd 152 8 CFR CFR NNP cord-274707-mxh38hwd 152 9 of of IN cord-274707-mxh38hwd 152 10 2.6 2.6 CD cord-274707-mxh38hwd 152 11 % % NN cord-274707-mxh38hwd 152 12 , , , cord-274707-mxh38hwd 152 13 however however RB cord-274707-mxh38hwd 152 14 , , , cord-274707-mxh38hwd 152 15 the the DT cord-274707-mxh38hwd 152 16 total total JJ cord-274707-mxh38hwd 152 17 number number NN cord-274707-mxh38hwd 152 18 of of IN cord-274707-mxh38hwd 152 19 COVID-19 covid-19 JJ cord-274707-mxh38hwd 152 20 cases case NNS cord-274707-mxh38hwd 152 21 is be VBZ cord-274707-mxh38hwd 152 22 likely likely RB cord-274707-mxh38hwd 152 23 higher high JJR cord-274707-mxh38hwd 152 24 due due IN cord-274707-mxh38hwd 152 25 to to IN cord-274707-mxh38hwd 152 26 inherent inherent JJ cord-274707-mxh38hwd 152 27 difficulties difficulty NNS cord-274707-mxh38hwd 152 28 in in IN cord-274707-mxh38hwd 152 29 identifying identify VBG cord-274707-mxh38hwd 152 30 and and CC cord-274707-mxh38hwd 152 31 counting count VBG cord-274707-mxh38hwd 152 32 mild mild JJ cord-274707-mxh38hwd 152 33 and and CC cord-274707-mxh38hwd 152 34 asymptomatic asymptomatic JJ cord-274707-mxh38hwd 152 35 cases case NNS cord-274707-mxh38hwd 152 36 ( ( -LRB- cord-274707-mxh38hwd 152 37 Wu Wu NNP cord-274707-mxh38hwd 152 38 & & CC cord-274707-mxh38hwd 152 39 McGoogan McGoogan NNP cord-274707-mxh38hwd 152 40 , , , cord-274707-mxh38hwd 152 41 2020 2020 CD cord-274707-mxh38hwd 152 42 ) ) -RRB- cord-274707-mxh38hwd 152 43 and and CC cord-274707-mxh38hwd 152 44 , , , cord-274707-mxh38hwd 152 45 it -PRON- PRP cord-274707-mxh38hwd 152 46 is be VBZ cord-274707-mxh38hwd 152 47 known know VBN cord-274707-mxh38hwd 152 48 that that IN cord-274707-mxh38hwd 152 49 asymptomatic asymptomatic JJ cord-274707-mxh38hwd 152 50 cases case NNS cord-274707-mxh38hwd 152 51 act act VBP cord-274707-mxh38hwd 152 52 as as IN cord-274707-mxh38hwd 152 53 carriers carrier NNS cord-274707-mxh38hwd 152 54 of of IN cord-274707-mxh38hwd 152 55 SARS SARS NNP cord-274707-mxh38hwd 152 56 - - HYPH cord-274707-mxh38hwd 152 57 CoV-2 CoV-2 NNP cord-274707-mxh38hwd 152 58 . . . cord-274707-mxh38hwd 153 1 However however RB cord-274707-mxh38hwd 153 2 the the DT cord-274707-mxh38hwd 153 3 mechanism mechanism NN cord-274707-mxh38hwd 153 4 by by IN cord-274707-mxh38hwd 153 5 which which WDT cord-274707-mxh38hwd 153 6 asymptomatic asymptomatic JJ cord-274707-mxh38hwd 153 7 carriers carrier NNS cord-274707-mxh38hwd 153 8 could could MD cord-274707-mxh38hwd 153 9 acquire acquire VB cord-274707-mxh38hwd 153 10 and and CC cord-274707-mxh38hwd 153 11 transmit transmit VB cord-274707-mxh38hwd 153 12 SARS SARS NNP cord-274707-mxh38hwd 153 13 - - HYPH cord-274707-mxh38hwd 153 14 CoV-2 CoV-2 NNP cord-274707-mxh38hwd 153 15 still still RB cord-274707-mxh38hwd 153 16 requires require VBZ cord-274707-mxh38hwd 153 17 further further JJ cord-274707-mxh38hwd 153 18 study study NN cord-274707-mxh38hwd 153 19 ( ( -LRB- cord-274707-mxh38hwd 153 20 Bai Bai NNP cord-274707-mxh38hwd 153 21 et et FW cord-274707-mxh38hwd 153 22 al al NNP cord-274707-mxh38hwd 153 23 . . NNP cord-274707-mxh38hwd 153 24 , , , cord-274707-mxh38hwd 153 25 2020 2020 CD cord-274707-mxh38hwd 153 26 ) ) -RRB- cord-274707-mxh38hwd 153 27 . . . cord-274707-mxh38hwd 154 1 The the DT cord-274707-mxh38hwd 154 2 effort effort NN cord-274707-mxh38hwd 154 3 to to TO cord-274707-mxh38hwd 154 4 contain contain VB cord-274707-mxh38hwd 154 5 the the DT cord-274707-mxh38hwd 154 6 outbreak outbreak NN cord-274707-mxh38hwd 154 7 is be VBZ cord-274707-mxh38hwd 154 8 limited limit VBN cord-274707-mxh38hwd 154 9 by by IN cord-274707-mxh38hwd 154 10 one one CD cord-274707-mxh38hwd 154 11 hard hard JJ cord-274707-mxh38hwd 154 12 problem problem NN cord-274707-mxh38hwd 154 13 : : : cord-274707-mxh38hwd 154 14 how how WRB cord-274707-mxh38hwd 154 15 to to TO cord-274707-mxh38hwd 154 16 differentiate differentiate VB cord-274707-mxh38hwd 154 17 COVID-19 covid-19 JJ cord-274707-mxh38hwd 154 18 cases case NNS cord-274707-mxh38hwd 154 19 from from IN cord-274707-mxh38hwd 154 20 the the DT cord-274707-mxh38hwd 154 21 healthy healthy JJ cord-274707-mxh38hwd 154 22 . . . cord-274707-mxh38hwd 155 1 For for IN cord-274707-mxh38hwd 155 2 confirmed confirm VBN cord-274707-mxh38hwd 155 3 COVID-19 covid-19 CD cord-274707-mxh38hwd 155 4 cases case NNS cord-274707-mxh38hwd 155 5 reported report VBD cord-274707-mxh38hwd 155 6 the the DT cord-274707-mxh38hwd 155 7 common common JJ cord-274707-mxh38hwd 155 8 clinical clinical JJ cord-274707-mxh38hwd 155 9 symptoms symptom NNS cord-274707-mxh38hwd 155 10 include include VBP cord-274707-mxh38hwd 155 11 fever fever NN cord-274707-mxh38hwd 155 12 , , , cord-274707-mxh38hwd 155 13 cough cough NN cord-274707-mxh38hwd 155 14 , , , cord-274707-mxh38hwd 155 15 myalgia myalgia NN cord-274707-mxh38hwd 155 16 or or CC cord-274707-mxh38hwd 155 17 fatigue fatigue NN cord-274707-mxh38hwd 155 18 ) ) -RRB- cord-274707-mxh38hwd 155 19 . . . cord-274707-mxh38hwd 156 1 Yet yet RB cord-274707-mxh38hwd 156 2 these these DT cord-274707-mxh38hwd 156 3 symptoms symptom NNS cord-274707-mxh38hwd 156 4 are be VBP cord-274707-mxh38hwd 156 5 not not RB cord-274707-mxh38hwd 156 6 unique unique JJ cord-274707-mxh38hwd 156 7 features feature NNS cord-274707-mxh38hwd 156 8 of of IN cord-274707-mxh38hwd 156 9 COVID-19 covid-19 NN cord-274707-mxh38hwd 156 10 because because IN cord-274707-mxh38hwd 156 11 these these DT cord-274707-mxh38hwd 156 12 symptoms symptom NNS cord-274707-mxh38hwd 156 13 are be VBP cord-274707-mxh38hwd 156 14 similar similar JJ cord-274707-mxh38hwd 156 15 to to IN cord-274707-mxh38hwd 156 16 that that DT cord-274707-mxh38hwd 156 17 of of IN cord-274707-mxh38hwd 156 18 other other JJ cord-274707-mxh38hwd 156 19 virus virus NN cord-274707-mxh38hwd 156 20 - - HYPH cord-274707-mxh38hwd 156 21 infected infect VBN cord-274707-mxh38hwd 156 22 diseases disease NNS cord-274707-mxh38hwd 156 23 such such JJ cord-274707-mxh38hwd 156 24 as as IN cord-274707-mxh38hwd 156 25 influenza influenza NN cord-274707-mxh38hwd 156 26 ( ( -LRB- cord-274707-mxh38hwd 156 27 Wang Wang NNP cord-274707-mxh38hwd 156 28 et et NNP cord-274707-mxh38hwd 156 29 al al NNP cord-274707-mxh38hwd 156 30 . . NNP cord-274707-mxh38hwd 156 31 , , , cord-274707-mxh38hwd 156 32 2014 2014 CD cord-274707-mxh38hwd 156 33 ) ) -RRB- cord-274707-mxh38hwd 156 34 . . . cord-274707-mxh38hwd 157 1 It -PRON- PRP cord-274707-mxh38hwd 157 2 is be VBZ cord-274707-mxh38hwd 157 3 clear clear JJ cord-274707-mxh38hwd 157 4 the the DT cord-274707-mxh38hwd 157 5 urgent urgent JJ cord-274707-mxh38hwd 157 6 need need NN cord-274707-mxh38hwd 157 7 for for IN cord-274707-mxh38hwd 157 8 rapid rapid JJ cord-274707-mxh38hwd 157 9 , , , cord-274707-mxh38hwd 157 10 simple simple JJ cord-274707-mxh38hwd 157 11 to to TO cord-274707-mxh38hwd 157 12 use use VB cord-274707-mxh38hwd 157 13 , , , cord-274707-mxh38hwd 157 14 sensitive sensitive JJ cord-274707-mxh38hwd 157 15 and and CC cord-274707-mxh38hwd 157 16 accurate accurate JJ cord-274707-mxh38hwd 157 17 test test NN cord-274707-mxh38hwd 157 18 to to TO cord-274707-mxh38hwd 157 19 quickly quickly RB cord-274707-mxh38hwd 157 20 identify identify VB cord-274707-mxh38hwd 157 21 infected infected JJ cord-274707-mxh38hwd 157 22 patients patient NNS cord-274707-mxh38hwd 157 23 to to TO cord-274707-mxh38hwd 157 24 prevent prevent VB cord-274707-mxh38hwd 157 25 virus virus NN cord-274707-mxh38hwd 157 26 transmission transmission NN cord-274707-mxh38hwd 157 27 and and CC cord-274707-mxh38hwd 157 28 to to TO cord-274707-mxh38hwd 157 29 assure assure VB cord-274707-mxh38hwd 157 30 timely timely JJ cord-274707-mxh38hwd 157 31 treatment treatment NN cord-274707-mxh38hwd 157 32 of of IN cord-274707-mxh38hwd 157 33 patients patient NNS cord-274707-mxh38hwd 157 34 in in IN cord-274707-mxh38hwd 157 35 order order NN cord-274707-mxh38hwd 157 36 to to TO cord-274707-mxh38hwd 157 37 contain contain VB cord-274707-mxh38hwd 157 38 this this DT cord-274707-mxh38hwd 157 39 outbreak outbreak NN cord-274707-mxh38hwd 157 40 . . . cord-274707-mxh38hwd 158 1 We -PRON- PRP cord-274707-mxh38hwd 158 2 need need VBP cord-274707-mxh38hwd 158 3 to to TO cord-274707-mxh38hwd 158 4 acknowledge acknowledge VB cord-274707-mxh38hwd 158 5 that that IN cord-274707-mxh38hwd 158 6 all all DT cord-274707-mxh38hwd 158 7 three three CD cord-274707-mxh38hwd 158 8 methodologies methodology NNS cord-274707-mxh38hwd 158 9 exposed expose VBN cord-274707-mxh38hwd 158 10 here here RB cord-274707-mxh38hwd 158 11 have have VBP cord-274707-mxh38hwd 158 12 its -PRON- PRP$ cord-274707-mxh38hwd 158 13 advantages advantage NNS cord-274707-mxh38hwd 158 14 and and CC cord-274707-mxh38hwd 158 15 disadvantages disadvantage NNS cord-274707-mxh38hwd 158 16 and and CC cord-274707-mxh38hwd 158 17 they -PRON- PRP cord-274707-mxh38hwd 158 18 can can MD cord-274707-mxh38hwd 158 19 and and CC cord-274707-mxh38hwd 158 20 should should MD cord-274707-mxh38hwd 158 21 be be VB cord-274707-mxh38hwd 158 22 combined combine VBN cord-274707-mxh38hwd 158 23 to to TO cord-274707-mxh38hwd 158 24 address address VB cord-274707-mxh38hwd 158 25 this this DT cord-274707-mxh38hwd 158 26 crisis crisis NN cord-274707-mxh38hwd 158 27 to to TO cord-274707-mxh38hwd 158 28 map map VB cord-274707-mxh38hwd 158 29 the the DT cord-274707-mxh38hwd 158 30 course course NN cord-274707-mxh38hwd 158 31 of of IN cord-274707-mxh38hwd 158 32 the the DT cord-274707-mxh38hwd 158 33 disease disease NN cord-274707-mxh38hwd 158 34 and and CC cord-274707-mxh38hwd 158 35 assure assure VB cord-274707-mxh38hwd 158 36 that that DT cord-274707-mxh38hwd 158 37 is be VBZ cord-274707-mxh38hwd 158 38 not not RB cord-274707-mxh38hwd 158 39 spreading spread VBG cord-274707-mxh38hwd 158 40 any any DT cord-274707-mxh38hwd 158 41 further further RB cord-274707-mxh38hwd 158 42 . . . cord-274707-mxh38hwd 159 1 How how WRB cord-274707-mxh38hwd 159 2 will will MD cord-274707-mxh38hwd 159 3 country country NN cord-274707-mxh38hwd 159 4 - - HYPH cord-274707-mxh38hwd 159 5 based base VBN cord-274707-mxh38hwd 159 6 mitigation mitigation NN cord-274707-mxh38hwd 159 7 measures measure NNS cord-274707-mxh38hwd 159 8 influence influence VBP cord-274707-mxh38hwd 159 9 the the DT cord-274707-mxh38hwd 159 10 course course NN cord-274707-mxh38hwd 159 11 of of IN cord-274707-mxh38hwd 159 12 the the DT cord-274707-mxh38hwd 159 13 COVID-19 covid-19 JJ cord-274707-mxh38hwd 159 14 epidemic epidemic NN cord-274707-mxh38hwd 159 15 ? ? . cord-274707-mxh38hwd 160 1 Presumed Presumed NNP cord-274707-mxh38hwd 160 2 Asymptomatic Asymptomatic NNP cord-274707-mxh38hwd 160 3 Carrier Carrier NNP cord-274707-mxh38hwd 160 4 Transmission Transmission NNP cord-274707-mxh38hwd 160 5 of of IN cord-274707-mxh38hwd 160 6 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 160 7 Coronavirus Coronavirus NNP cord-274707-mxh38hwd 160 8 Painel Painel NNPS cord-274707-mxh38hwd 161 1 Coronavírus Coronavírus NNP cord-274707-mxh38hwd 161 2 Standardized standardized JJ cord-274707-mxh38hwd 161 3 definitions definition NNS cord-274707-mxh38hwd 161 4 of of IN cord-274707-mxh38hwd 161 5 molecular molecular JJ cord-274707-mxh38hwd 161 6 response response NN cord-274707-mxh38hwd 161 7 in in IN cord-274707-mxh38hwd 161 8 chronic chronic JJ cord-274707-mxh38hwd 161 9 myeloid myeloid NN cord-274707-mxh38hwd 161 10 leukemia leukemia NN cord-274707-mxh38hwd 161 11 Use use NN cord-274707-mxh38hwd 161 12 of of IN cord-274707-mxh38hwd 161 13 recombinant recombinant JJ cord-274707-mxh38hwd 161 14 envelope envelope NN cord-274707-mxh38hwd 161 15 proteins protein NNS cord-274707-mxh38hwd 161 16 for for IN cord-274707-mxh38hwd 161 17 serological serological JJ cord-274707-mxh38hwd 161 18 diagnosis diagnosis NN cord-274707-mxh38hwd 161 19 of of IN cord-274707-mxh38hwd 161 20 dengue dengue NN cord-274707-mxh38hwd 161 21 virus virus NN cord-274707-mxh38hwd 161 22 infection infection NN cord-274707-mxh38hwd 161 23 in in IN cord-274707-mxh38hwd 161 24 an an DT cord-274707-mxh38hwd 161 25 immunochromatographic immunochromatographic JJ cord-274707-mxh38hwd 161 26 assay assay NN cord-274707-mxh38hwd 161 27 Application Application NNP cord-274707-mxh38hwd 161 28 of of IN cord-274707-mxh38hwd 161 29 Polymerase Polymerase NNP cord-274707-mxh38hwd 161 30 Chain Chain NNP cord-274707-mxh38hwd 161 31 Reaction Reaction NNP cord-274707-mxh38hwd 161 32 to to IN cord-274707-mxh38hwd 161 33 the the DT cord-274707-mxh38hwd 161 34 Diagnosis Diagnosis NNP cord-274707-mxh38hwd 161 35 of of IN cord-274707-mxh38hwd 161 36 Infectious Infectious NNP cord-274707-mxh38hwd 161 37 Diseases Diseases NNPS cord-274707-mxh38hwd 161 38 Development Development NNP cord-274707-mxh38hwd 161 39 of of IN cord-274707-mxh38hwd 161 40 working work VBG cord-274707-mxh38hwd 161 41 reference reference NN cord-274707-mxh38hwd 161 42 materials material NNS cord-274707-mxh38hwd 161 43 for for IN cord-274707-mxh38hwd 161 44 clinical clinical JJ cord-274707-mxh38hwd 161 45 virology virology NN cord-274707-mxh38hwd 161 46 Enzyme enzyme NN cord-274707-mxh38hwd 161 47 immunoassay immunoassay NN cord-274707-mxh38hwd 161 48 and and CC cord-274707-mxh38hwd 161 49 enzyme enzyme NN cord-274707-mxh38hwd 161 50 - - HYPH cord-274707-mxh38hwd 161 51 linked link VBN cord-274707-mxh38hwd 161 52 immunosorbent immunosorbent JJ cord-274707-mxh38hwd 161 53 assay assay NN cord-274707-mxh38hwd 161 54 Development Development NNP cord-274707-mxh38hwd 161 55 of of IN cord-274707-mxh38hwd 161 56 an an DT cord-274707-mxh38hwd 161 57 ultrasensitive ultrasensitive JJ cord-274707-mxh38hwd 161 58 immunochromatography immunochromatography NN cord-274707-mxh38hwd 161 59 test test NN cord-274707-mxh38hwd 161 60 to to TO cord-274707-mxh38hwd 161 61 detect detect VB cord-274707-mxh38hwd 161 62 nicotine nicotine NN cord-274707-mxh38hwd 161 63 metabolites metabolite NNS cord-274707-mxh38hwd 161 64 in in IN cord-274707-mxh38hwd 161 65 oral oral JJ cord-274707-mxh38hwd 161 66 fluids fluid NNS cord-274707-mxh38hwd 161 67 Rapid rapid JJ cord-274707-mxh38hwd 161 68 detection detection NN cord-274707-mxh38hwd 161 69 and and CC cord-274707-mxh38hwd 161 70 differentiation differentiation NN cord-274707-mxh38hwd 161 71 of of IN cord-274707-mxh38hwd 161 72 antibodies antibody NNS cord-274707-mxh38hwd 161 73 to to IN cord-274707-mxh38hwd 161 74 HIV-1 HIV-1 NNP cord-274707-mxh38hwd 161 75 and and CC cord-274707-mxh38hwd 161 76 HIV-2 HIV-2 NNP cord-274707-mxh38hwd 161 77 using use VBG cord-274707-mxh38hwd 161 78 multivalent multivalent JJ cord-274707-mxh38hwd 161 79 antigens antigen NNS cord-274707-mxh38hwd 161 80 and and CC cord-274707-mxh38hwd 161 81 magnetic magnetic JJ cord-274707-mxh38hwd 161 82 immunochromatography immunochromatography NN cord-274707-mxh38hwd 161 83 testing test VBG cord-274707-mxh38hwd 161 84 Simultaneous Simultaneous NNP cord-274707-mxh38hwd 161 85 Amplification Amplification NNP cord-274707-mxh38hwd 161 86 and and CC cord-274707-mxh38hwd 161 87 Detection Detection NNP cord-274707-mxh38hwd 161 88 of of IN cord-274707-mxh38hwd 161 89 Specific specific JJ cord-274707-mxh38hwd 161 90 DNA DNA NNP cord-274707-mxh38hwd 161 91 Sequences Sequences NNP cord-274707-mxh38hwd 161 92 Clinical clinical JJ cord-274707-mxh38hwd 161 93 features feature NNS cord-274707-mxh38hwd 161 94 of of IN cord-274707-mxh38hwd 161 95 patients patient NNS cord-274707-mxh38hwd 161 96 infected infect VBN cord-274707-mxh38hwd 161 97 with with IN cord-274707-mxh38hwd 161 98 2019 2019 CD cord-274707-mxh38hwd 161 99 novel novel JJ cord-274707-mxh38hwd 161 100 coronavirus coronavirus NN cord-274707-mxh38hwd 161 101 in in IN cord-274707-mxh38hwd 161 102 Wuhan Wuhan NNP cord-274707-mxh38hwd 161 103 Gold Gold NNP cord-274707-mxh38hwd 161 104 nanoparticle nanoparticle NN cord-274707-mxh38hwd 161 105 - - HYPH cord-274707-mxh38hwd 161 106 based base VBN cord-274707-mxh38hwd 161 107 immunochromatographic immunochromatographic JJ cord-274707-mxh38hwd 161 108 assay assay NN cord-274707-mxh38hwd 161 109 for for IN cord-274707-mxh38hwd 161 110 the the DT cord-274707-mxh38hwd 161 111 detection detection NN cord-274707-mxh38hwd 161 112 of of IN cord-274707-mxh38hwd 161 113 Staphylococcus Staphylococcus NNP cord-274707-mxh38hwd 161 114 aureus aureus NN cord-274707-mxh38hwd 161 115 Considerations consideration NNS cord-274707-mxh38hwd 161 116 for for IN cord-274707-mxh38hwd 161 117 digital digital JJ cord-274707-mxh38hwd 161 118 PCR PCR NNP cord-274707-mxh38hwd 161 119 as as IN cord-274707-mxh38hwd 161 120 an an DT cord-274707-mxh38hwd 161 121 accurate accurate JJ cord-274707-mxh38hwd 161 122 molecular molecular JJ cord-274707-mxh38hwd 161 123 diagnostic diagnostic JJ cord-274707-mxh38hwd 161 124 tool tool NN cord-274707-mxh38hwd 161 125 A a DT cord-274707-mxh38hwd 161 126 distinct distinct JJ cord-274707-mxh38hwd 161 127 name name NN cord-274707-mxh38hwd 161 128 is be VBZ cord-274707-mxh38hwd 161 129 needed need VBN cord-274707-mxh38hwd 161 130 for for IN cord-274707-mxh38hwd 161 131 the the DT cord-274707-mxh38hwd 161 132 new new JJ cord-274707-mxh38hwd 161 133 coronavirus coronavirus NN cord-274707-mxh38hwd 161 134 Production production NN cord-274707-mxh38hwd 161 135 of of IN cord-274707-mxh38hwd 161 136 specific specific JJ cord-274707-mxh38hwd 161 137 antibodies antibody NNS cord-274707-mxh38hwd 161 138 against against IN cord-274707-mxh38hwd 161 139 SARS SARS NNP cord-274707-mxh38hwd 161 140 - - HYPH cord-274707-mxh38hwd 161 141 coronavirus coronavirus NN cord-274707-mxh38hwd 161 142 nucleocapsid nucleocapsid NN cord-274707-mxh38hwd 161 143 protein protein NN cord-274707-mxh38hwd 161 144 without without IN cord-274707-mxh38hwd 161 145 cross cross NN cord-274707-mxh38hwd 161 146 reactivity reactivity NN cord-274707-mxh38hwd 161 147 with with IN cord-274707-mxh38hwd 161 148 human human JJ cord-274707-mxh38hwd 161 149 coronaviruses coronaviruse NNS cord-274707-mxh38hwd 161 150 229E 229e CD cord-274707-mxh38hwd 161 151 and and CC cord-274707-mxh38hwd 161 152 OC43 OC43 NNP cord-274707-mxh38hwd 161 153 Early Early NNP cord-274707-mxh38hwd 161 154 Transmission Transmission NNP cord-274707-mxh38hwd 161 155 Dynamics Dynamics NNPS cord-274707-mxh38hwd 161 156 in in IN cord-274707-mxh38hwd 161 157 Wuhan Wuhan NNP cord-274707-mxh38hwd 161 158 , , , cord-274707-mxh38hwd 161 159 China China NNP cord-274707-mxh38hwd 161 160 , , , cord-274707-mxh38hwd 161 161 of of IN cord-274707-mxh38hwd 161 162 Novel Novel NNP cord-274707-mxh38hwd 161 163 Coronavirus Coronavirus NNP cord-274707-mxh38hwd 161 164 - - HYPH cord-274707-mxh38hwd 161 165 Infected Infected NNP cord-274707-mxh38hwd 161 166 Pneumonia Pneumonia NNP cord-274707-mxh38hwd 161 167 Development Development NNP cord-274707-mxh38hwd 161 168 and and CC cord-274707-mxh38hwd 161 169 Clinical Clinical NNP cord-274707-mxh38hwd 161 170 Application Application NNP cord-274707-mxh38hwd 161 171 of of IN cord-274707-mxh38hwd 161 172 A a DT cord-274707-mxh38hwd 161 173 Rapid Rapid NNP cord-274707-mxh38hwd 161 174 IgM IgM NNP cord-274707-mxh38hwd 161 175 - - HYPH cord-274707-mxh38hwd 161 176 IgG IgG NNP cord-274707-mxh38hwd 161 177 Combined Combined NNP cord-274707-mxh38hwd 161 178 Antibody Antibody NNP cord-274707-mxh38hwd 161 179 Test Test NNP cord-274707-mxh38hwd 161 180 for for IN cord-274707-mxh38hwd 161 181 SARS SARS NNP cord-274707-mxh38hwd 161 182 - - HYPH cord-274707-mxh38hwd 161 183 CoV-2 CoV-2 NNP cord-274707-mxh38hwd 161 184 Infection infection NN cord-274707-mxh38hwd 161 185 Diagnosis diagnosis NN cord-274707-mxh38hwd 161 186 Serological serological JJ cord-274707-mxh38hwd 161 187 assays assay NNS cord-274707-mxh38hwd 161 188 for for IN cord-274707-mxh38hwd 161 189 emerging emerge VBG cord-274707-mxh38hwd 161 190 coronaviruses coronaviruse NNS cord-274707-mxh38hwd 161 191 : : : cord-274707-mxh38hwd 161 192 Challenges challenge NNS cord-274707-mxh38hwd 161 193 and and CC cord-274707-mxh38hwd 161 194 pitfalls pitfall NNS cord-274707-mxh38hwd 161 195 Cholinesterase Cholinesterase NNP cord-274707-mxh38hwd 161 196 - - HYPH cord-274707-mxh38hwd 161 197 based base VBN cord-274707-mxh38hwd 161 198 dipstick dipstick NN cord-274707-mxh38hwd 161 199 assay assay NN cord-274707-mxh38hwd 161 200 for for IN cord-274707-mxh38hwd 161 201 the the DT cord-274707-mxh38hwd 161 202 detection detection NN cord-274707-mxh38hwd 161 203 of of IN cord-274707-mxh38hwd 161 204 organophosphate organophosphate NN cord-274707-mxh38hwd 161 205 and and CC cord-274707-mxh38hwd 161 206 carbamatepesticides carbamatepesticide NNS cord-274707-mxh38hwd 161 207 Evolution Evolution NNP cord-274707-mxh38hwd 161 208 in in IN cord-274707-mxh38hwd 161 209 Lateral Lateral NNP cord-274707-mxh38hwd 161 210 Flow Flow NNP cord-274707-mxh38hwd 161 211 - - HYPH cord-274707-mxh38hwd 161 212 Based Based NNP cord-274707-mxh38hwd 161 213 Immunoassay Immunoassay NNP cord-274707-mxh38hwd 161 214 Systems Systems NNPS cord-274707-mxh38hwd 161 215 Designing design VBG cord-274707-mxh38hwd 161 216 novel novel NN cord-274707-mxh38hwd 161 217 nano nano NN cord-274707-mxh38hwd 161 218 - - HYPH cord-274707-mxh38hwd 161 219 immunoassays immunoassays NNP cord-274707-mxh38hwd 161 220 : : : cord-274707-mxh38hwd 162 1 Antibody antibody NN cord-274707-mxh38hwd 162 2 orientation orientation NN cord-274707-mxh38hwd 162 3 versus versus IN cord-274707-mxh38hwd 162 4 sensitivity sensitivity NN cord-274707-mxh38hwd 162 5 IgM IgM NNP cord-274707-mxh38hwd 162 6 in in IN cord-274707-mxh38hwd 162 7 microbial microbial JJ cord-274707-mxh38hwd 162 8 infections infection NNS cord-274707-mxh38hwd 162 9 : : : cord-274707-mxh38hwd 163 1 Taken take VBN cord-274707-mxh38hwd 163 2 for for IN cord-274707-mxh38hwd 163 3 granted grant VBN cord-274707-mxh38hwd 163 4 Detection detection NN cord-274707-mxh38hwd 163 5 and and CC cord-274707-mxh38hwd 163 6 identification identification NN cord-274707-mxh38hwd 163 7 of of IN cord-274707-mxh38hwd 163 8 previously previously RB cord-274707-mxh38hwd 163 9 unrecognized unrecognized JJ cord-274707-mxh38hwd 163 10 microbial microbial JJ cord-274707-mxh38hwd 163 11 pathogens pathogen NNS cord-274707-mxh38hwd 163 12 On on IN cord-274707-mxh38hwd 163 13 the the DT cord-274707-mxh38hwd 163 14 origin origin NN cord-274707-mxh38hwd 163 15 and and CC cord-274707-mxh38hwd 163 16 continuing continue VBG cord-274707-mxh38hwd 163 17 evolution evolution NN cord-274707-mxh38hwd 163 18 of of IN cord-274707-mxh38hwd 163 19 SARS SARS NNP cord-274707-mxh38hwd 163 20 - - HYPH cord-274707-mxh38hwd 163 21 CoV-2 CoV-2 NNP cord-274707-mxh38hwd 163 22 Comparison comparison NN cord-274707-mxh38hwd 163 23 of of IN cord-274707-mxh38hwd 163 24 patients patient NNS cord-274707-mxh38hwd 163 25 hospitalized hospitalize VBN cord-274707-mxh38hwd 163 26 with with IN cord-274707-mxh38hwd 163 27 influenza influenza NN cord-274707-mxh38hwd 163 28 a a DT cord-274707-mxh38hwd 163 29 subtypes subtypes NN cord-274707-mxh38hwd 163 30 H7N9 H7N9 NNP cord-274707-mxh38hwd 163 31 , , , cord-274707-mxh38hwd 163 32 H5N1 H5N1 NNP cord-274707-mxh38hwd 163 33 , , , cord-274707-mxh38hwd 163 34 and and CC cord-274707-mxh38hwd 163 35 2009 2009 CD cord-274707-mxh38hwd 163 36 pandemic pandemic NN cord-274707-mxh38hwd 164 1 H1N1 H1N1 NNP cord-274707-mxh38hwd 164 2 A a DT cord-274707-mxh38hwd 164 3 novel novel JJ cord-274707-mxh38hwd 164 4 coronavirus coronavirus NN cord-274707-mxh38hwd 164 5 outbreak outbreak NN cord-274707-mxh38hwd 164 6 of of IN cord-274707-mxh38hwd 164 7 global global JJ cord-274707-mxh38hwd 164 8 health health NN cord-274707-mxh38hwd 164 9 concern concern NN cord-274707-mxh38hwd 164 10 WHO WHO NNP cord-274707-mxh38hwd 164 11 -World -World HYPH cord-274707-mxh38hwd 164 12 Health Health NNP cord-274707-mxh38hwd 164 13 Organization Organization NNP cord-274707-mxh38hwd 164 14 . . . cord-274707-mxh38hwd 165 1 Coronavirus Coronavirus NNP cord-274707-mxh38hwd 165 2 disease disease NN cord-274707-mxh38hwd 165 3 ( ( -LRB- cord-274707-mxh38hwd 165 4 COVID-19 covid-19 VB cord-274707-mxh38hwd 165 5 ) ) -RRB- cord-274707-mxh38hwd 165 6 Pandemic Pandemic NNP cord-274707-mxh38hwd 165 7 Laboratory Laboratory NNP cord-274707-mxh38hwd 165 8 testing test VBG cord-274707-mxh38hwd 165 9 for for IN cord-274707-mxh38hwd 165 10 2019 2019 CD cord-274707-mxh38hwd 165 11 novel novel JJ cord-274707-mxh38hwd 165 12 coronavirus coronavirus NN cord-274707-mxh38hwd 165 13 ( ( -LRB- cord-274707-mxh38hwd 165 14 2019-nCoV 2019-ncov CD cord-274707-mxh38hwd 165 15 ) ) -RRB- cord-274707-mxh38hwd 165 16 in in IN cord-274707-mxh38hwd 165 17 suspected suspect VBN cord-274707-mxh38hwd 165 18 human human JJ cord-274707-mxh38hwd 165 19 cases case NNS cord-274707-mxh38hwd 165 20 . . . cord-274707-mxh38hwd 166 1 Interim interim JJ cord-274707-mxh38hwd 166 2 guidance guidance NN cord-274707-mxh38hwd 167 1 A a DT cord-274707-mxh38hwd 167 2 new new JJ cord-274707-mxh38hwd 167 3 coronavirus coronavirus NN cord-274707-mxh38hwd 167 4 associated associate VBN cord-274707-mxh38hwd 167 5 with with IN cord-274707-mxh38hwd 167 6 human human JJ cord-274707-mxh38hwd 167 7 respiratory respiratory JJ cord-274707-mxh38hwd 167 8 disease disease NN cord-274707-mxh38hwd 167 9 in in IN cord-274707-mxh38hwd 167 10 China China NNP cord-274707-mxh38hwd 167 11 Characteristics Characteristics NNPS cord-274707-mxh38hwd 167 12 of of IN cord-274707-mxh38hwd 167 13 and and CC cord-274707-mxh38hwd 167 14 Important Important NNP cord-274707-mxh38hwd 167 15 Lessons lesson NNS cord-274707-mxh38hwd 167 16 from from IN cord-274707-mxh38hwd 167 17 the the DT cord-274707-mxh38hwd 167 18 Coronavirus Coronavirus NNP cord-274707-mxh38hwd 167 19 Disease Disease NNP cord-274707-mxh38hwd 167 20 2019 2019 CD cord-274707-mxh38hwd 168 1 ( ( -LRB- cord-274707-mxh38hwd 168 2 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 168 3 ) ) -RRB- cord-274707-mxh38hwd 168 4 Outbreak outbreak NN cord-274707-mxh38hwd 168 5 in in IN cord-274707-mxh38hwd 168 6 China China NNP cord-274707-mxh38hwd 168 7 : : : cord-274707-mxh38hwd 169 1 Summary summary NN cord-274707-mxh38hwd 169 2 of of IN cord-274707-mxh38hwd 169 3 a a DT cord-274707-mxh38hwd 169 4 Report Report NNP cord-274707-mxh38hwd 169 5 of of IN cord-274707-mxh38hwd 169 6 72314 72314 CD cord-274707-mxh38hwd 169 7 Cases case NNS cord-274707-mxh38hwd 169 8 from from IN cord-274707-mxh38hwd 169 9 the the DT cord-274707-mxh38hwd 169 10 Chinese Chinese NNP cord-274707-mxh38hwd 169 11 Center Center NNP cord-274707-mxh38hwd 169 12 for for IN cord-274707-mxh38hwd 169 13 Disease Disease NNP cord-274707-mxh38hwd 169 14 Control Control NNP cord-274707-mxh38hwd 169 15 and and CC cord-274707-mxh38hwd 169 16 Prevention Prevention NNP cord-274707-mxh38hwd 169 17 Evolving Evolving NNP cord-274707-mxh38hwd 169 18 status status NN cord-274707-mxh38hwd 169 19 of of IN cord-274707-mxh38hwd 169 20 the the DT cord-274707-mxh38hwd 169 21 2019 2019 CD cord-274707-mxh38hwd 169 22 novel novel JJ cord-274707-mxh38hwd 169 23 coronavirus coronavirus NN cord-274707-mxh38hwd 169 24 infection infection NN cord-274707-mxh38hwd 169 25 : : : cord-274707-mxh38hwd 169 26 Proposal proposal NN cord-274707-mxh38hwd 169 27 of of IN cord-274707-mxh38hwd 169 28 conventional conventional JJ cord-274707-mxh38hwd 169 29 serologic serologic JJ cord-274707-mxh38hwd 169 30 assays assay NNS cord-274707-mxh38hwd 169 31 for for IN cord-274707-mxh38hwd 169 32 disease disease NN cord-274707-mxh38hwd 169 33 diagnosis diagnosis NN cord-274707-mxh38hwd 169 34 and and CC cord-274707-mxh38hwd 169 35 infection infection NN cord-274707-mxh38hwd 169 36 monitoring monitor VBG cord-274707-mxh38hwd 169 37 A a DT cord-274707-mxh38hwd 169 38 Gold Gold NNP cord-274707-mxh38hwd 169 39 - - HYPH cord-274707-mxh38hwd 169 40 Nanoparticle Nanoparticle NNP cord-274707-mxh38hwd 169 41 - - HYPH cord-274707-mxh38hwd 169 42 Based Based NNP cord-274707-mxh38hwd 169 43 Real Real NNP cord-274707-mxh38hwd 169 44 - - HYPH cord-274707-mxh38hwd 169 45 Time Time NNP cord-274707-mxh38hwd 169 46 Colorimetric colorimetric JJ cord-274707-mxh38hwd 169 47 Screening Screening NNP cord-274707-mxh38hwd 169 48 Method Method NNP cord-274707-mxh38hwd 169 49 for for IN cord-274707-mxh38hwd 169 50 Endonuclease Endonuclease NNP cord-274707-mxh38hwd 169 51 Activity Activity NNP cord-274707-mxh38hwd 169 52 and and CC cord-274707-mxh38hwd 169 53 Inhibition Inhibition NNP cord-274707-mxh38hwd 169 54 Immunoassay Immunoassay NNP cord-274707-mxh38hwd 169 55 of of IN cord-274707-mxh38hwd 169 56 endogenous endogenous JJ cord-274707-mxh38hwd 169 57 plasma plasma NN cord-274707-mxh38hwd 169 58 insulin insulin NN cord-274707-mxh38hwd 169 59 in in IN cord-274707-mxh38hwd 169 60 man man NN cord-274707-mxh38hwd 170 1 The the DT cord-274707-mxh38hwd 170 2 different different JJ cord-274707-mxh38hwd 170 3 tests test NNS cord-274707-mxh38hwd 170 4 for for IN cord-274707-mxh38hwd 170 5 the the DT cord-274707-mxh38hwd 170 6 diagnosis diagnosis NN cord-274707-mxh38hwd 170 7 of of IN cord-274707-mxh38hwd 170 8 COVID-19 COVID-19 NNP cord-274707-mxh38hwd 170 9 -Laureano -laureano NN cord-274707-mxh38hwd 170 10 Immunochromatographic Immunochromatographic NNP cord-274707-mxh38hwd 170 11 assay assay NN cord-274707-mxh38hwd 170 12 on on IN cord-274707-mxh38hwd 170 13 thread thread NN cord-274707-mxh38hwd 170 14 SARS SARS NNP cord-274707-mxh38hwd 170 15 - - HYPH cord-274707-mxh38hwd 170 16 CoV-2 CoV-2 NNP cord-274707-mxh38hwd 170 17 Viral Viral NNP cord-274707-mxh38hwd 170 18 Load Load NNP cord-274707-mxh38hwd 170 19 in in IN cord-274707-mxh38hwd 170 20 Upper Upper NNP cord-274707-mxh38hwd 170 21 Respiratory respiratory JJ cord-274707-mxh38hwd 170 22 Specimens specimen NNS cord-274707-mxh38hwd 170 23 of of IN cord-274707-mxh38hwd 170 24 Infected infected JJ cord-274707-mxh38hwd 170 25 Patients patient NNS