id sid tid token lemma pos cord-274141-vujx538o 1 1 key key NN cord-274141-vujx538o 1 2 : : : cord-274141-vujx538o 1 3 cord-274141-vujx538o cord-274141-vujx538o ADD cord-274141-vujx538o 2 1 authors author NNS cord-274141-vujx538o 2 2 : : : cord-274141-vujx538o 2 3 Chinsembu Chinsembu NNP cord-274141-vujx538o 2 4 , , , cord-274141-vujx538o 2 5 Kazhila Kazhila NNP cord-274141-vujx538o 2 6 C. C. NNP cord-274141-vujx538o 2 7 title title NN cord-274141-vujx538o 2 8 : : : cord-274141-vujx538o 3 1 Coronaviruses Coronaviruses NNP cord-274141-vujx538o 3 2 and and CC cord-274141-vujx538o 3 3 Nature Nature NNP cord-274141-vujx538o 3 4 ’s ’s POS cord-274141-vujx538o 3 5 Pharmacy Pharmacy NNP cord-274141-vujx538o 3 6 for for IN cord-274141-vujx538o 3 7 the the DT cord-274141-vujx538o 3 8 Relief Relief NNP cord-274141-vujx538o 3 9 of of IN cord-274141-vujx538o 3 10 Coronavirus Coronavirus NNP cord-274141-vujx538o 3 11 Disease Disease NNP cord-274141-vujx538o 3 12 2019 2019 CD cord-274141-vujx538o 3 13 date date NN cord-274141-vujx538o 3 14 : : : cord-274141-vujx538o 3 15 2020 2020 CD cord-274141-vujx538o 3 16 - - SYM cord-274141-vujx538o 3 17 10 10 CD cord-274141-vujx538o 3 18 - - HYPH cord-274141-vujx538o 3 19 06 06 CD cord-274141-vujx538o 3 20 journal journal NN cord-274141-vujx538o 3 21 : : : cord-274141-vujx538o 4 1 Rev Rev NNP cord-274141-vujx538o 4 2 Bras Bras NNP cord-274141-vujx538o 4 3 Farmacogn Farmacogn NNP cord-274141-vujx538o 4 4 DOI doi NN cord-274141-vujx538o 4 5 : : : cord-274141-vujx538o 5 1 10.1007 10.1007 CD cord-274141-vujx538o 5 2 / / SYM cord-274141-vujx538o 5 3 s43450 s43450 NN cord-274141-vujx538o 5 4 - - HYPH cord-274141-vujx538o 5 5 020 020 CD cord-274141-vujx538o 5 6 - - HYPH cord-274141-vujx538o 5 7 00104 00104 CD cord-274141-vujx538o 5 8 - - SYM cord-274141-vujx538o 5 9 7 7 CD cord-274141-vujx538o 5 10 sha sha NN cord-274141-vujx538o 5 11 : : : cord-274141-vujx538o 6 1 71f58e71c052a31ac1854e32849c6f17cd9e29de 71f58e71c052a31ac1854e32849c6f17cd9e29de NNP cord-274141-vujx538o 6 2 doc_id doc_id CD cord-274141-vujx538o 6 3 : : : cord-274141-vujx538o 7 1 274141 274141 CD cord-274141-vujx538o 7 2 cord_uid cord_uid NNS cord-274141-vujx538o 7 3 : : : cord-274141-vujx538o 7 4 vujx538o vujx538o . cord-274141-vujx538o 8 1 [ [ -LRB- cord-274141-vujx538o 8 2 Image image NN cord-274141-vujx538o 8 3 : : : cord-274141-vujx538o 8 4 see see VB cord-274141-vujx538o 8 5 text text NN cord-274141-vujx538o 8 6 ] ] -RRB- cord-274141-vujx538o 9 1 Coronaviruses Coronaviruses NNP cord-274141-vujx538o 9 2 ( ( -LRB- cord-274141-vujx538o 9 3 CoVs CoVs NNP cord-274141-vujx538o 9 4 ) ) -RRB- cord-274141-vujx538o 9 5 cause cause VB cord-274141-vujx538o 9 6 acute acute JJ cord-274141-vujx538o 9 7 and and CC cord-274141-vujx538o 9 8 chronic chronic JJ cord-274141-vujx538o 9 9 respiratory respiratory NN cord-274141-vujx538o 9 10 , , , cord-274141-vujx538o 9 11 enteric enteric JJ cord-274141-vujx538o 9 12 , , , cord-274141-vujx538o 9 13 and and CC cord-274141-vujx538o 9 14 central central JJ cord-274141-vujx538o 9 15 nervous nervous JJ cord-274141-vujx538o 9 16 system system NN cord-274141-vujx538o 9 17 diseases disease NNS cord-274141-vujx538o 9 18 in in IN cord-274141-vujx538o 9 19 many many JJ cord-274141-vujx538o 9 20 species specie NNS cord-274141-vujx538o 9 21 of of IN cord-274141-vujx538o 9 22 animals animal NNS cord-274141-vujx538o 9 23 including include VBG cord-274141-vujx538o 9 24 humans human NNS cord-274141-vujx538o 9 25 . . . cord-274141-vujx538o 10 1 While while IN cord-274141-vujx538o 10 2 the the DT cord-274141-vujx538o 10 3 history history NN cord-274141-vujx538o 10 4 of of IN cord-274141-vujx538o 10 5 CoVs CoVs NNP cord-274141-vujx538o 10 6 dates date NNS cord-274141-vujx538o 10 7 as as RB cord-274141-vujx538o 10 8 far far RB cord-274141-vujx538o 10 9 back back RB cord-274141-vujx538o 10 10 as as IN cord-274141-vujx538o 10 11 the the DT cord-274141-vujx538o 10 12 1940s 1940 NNS cord-274141-vujx538o 10 13 , , , cord-274141-vujx538o 10 14 identification identification NN cord-274141-vujx538o 10 15 of of IN cord-274141-vujx538o 10 16 the the DT cord-274141-vujx538o 10 17 first first JJ cord-274141-vujx538o 10 18 human human JJ cord-274141-vujx538o 10 19 CoVs covs NN cord-274141-vujx538o 10 20 ( ( -LRB- cord-274141-vujx538o 10 21 HCoVs HCoVs NNP cord-274141-vujx538o 10 22 ) ) -RRB- cord-274141-vujx538o 10 23 as as IN cord-274141-vujx538o 10 24 causative causative JJ cord-274141-vujx538o 10 25 agents agent NNS cord-274141-vujx538o 10 26 of of IN cord-274141-vujx538o 10 27 mild mild JJ cord-274141-vujx538o 10 28 respiratory respiratory JJ cord-274141-vujx538o 10 29 infections infection NNS cord-274141-vujx538o 10 30 was be VBD cord-274141-vujx538o 10 31 reported report VBN cord-274141-vujx538o 10 32 in in IN cord-274141-vujx538o 10 33 the the DT cord-274141-vujx538o 10 34 1960s 1960 NNS cord-274141-vujx538o 10 35 . . . cord-274141-vujx538o 11 1 These these DT cord-274141-vujx538o 11 2 HCoVs HCoVs NNP cord-274141-vujx538o 11 3 were be VBD cord-274141-vujx538o 11 4 named name VBN cord-274141-vujx538o 11 5 human human JJ cord-274141-vujx538o 11 6 CoV CoV NNP cord-274141-vujx538o 11 7 229E 229e CD cord-274141-vujx538o 11 8 ( ( -LRB- cord-274141-vujx538o 11 9 HCoV-229E HCoV-229E NNP cord-274141-vujx538o 11 10 ) ) -RRB- cord-274141-vujx538o 12 1 and and CC cord-274141-vujx538o 12 2 HCoV HCoV NNP cord-274141-vujx538o 12 3 - - HYPH cord-274141-vujx538o 12 4 OC43 OC43 NNP cord-274141-vujx538o 12 5 ( ( -LRB- cord-274141-vujx538o 12 6 Pillaiyar Pillaiyar NNP cord-274141-vujx538o 12 7 et et NNP cord-274141-vujx538o 12 8 al al NNP cord-274141-vujx538o 12 9 . . NNP cord-274141-vujx538o 12 10 2020 2020 CD cord-274141-vujx538o 12 11 ) ) -RRB- cord-274141-vujx538o 12 12 . . . cord-274141-vujx538o 13 1 The the DT cord-274141-vujx538o 13 2 replication replication NN cord-274141-vujx538o 13 3 and and CC cord-274141-vujx538o 13 4 pathogenesis pathogenesis NN cord-274141-vujx538o 13 5 of of IN cord-274141-vujx538o 13 6 CoVs CoVs NNP cord-274141-vujx538o 13 7 were be VBD cord-274141-vujx538o 13 8 actively actively RB cord-274141-vujx538o 13 9 studied study VBN cord-274141-vujx538o 13 10 by by IN cord-274141-vujx538o 13 11 virologists virologist NNS cord-274141-vujx538o 13 12 in in IN cord-274141-vujx538o 13 13 the the DT cord-274141-vujx538o 13 14 1970s 1970 NNS cord-274141-vujx538o 13 15 , , , cord-274141-vujx538o 13 16 leading lead VBG cord-274141-vujx538o 13 17 to to IN cord-274141-vujx538o 13 18 the the DT cord-274141-vujx538o 13 19 discovery discovery NN cord-274141-vujx538o 13 20 of of IN cord-274141-vujx538o 13 21 four four CD cord-274141-vujx538o 13 22 other other JJ cord-274141-vujx538o 13 23 human human JJ cord-274141-vujx538o 13 24 CoVs covs NN cord-274141-vujx538o 13 25 , , , cord-274141-vujx538o 13 26 namely namely RB cord-274141-vujx538o 13 27 HCoV HCoV NNP cord-274141-vujx538o 13 28 - - HYPH cord-274141-vujx538o 13 29 Hong Hong NNP cord-274141-vujx538o 13 30 Kong Kong NNP cord-274141-vujx538o 13 31 University University NNP cord-274141-vujx538o 13 32 1 1 CD cord-274141-vujx538o 13 33 ( ( -LRB- cord-274141-vujx538o 13 34 HCoV HCoV NNP cord-274141-vujx538o 13 35 - - HYPH cord-274141-vujx538o 13 36 HKU1 HKU1 NNP cord-274141-vujx538o 13 37 ) ) -RRB- cord-274141-vujx538o 13 38 , , , cord-274141-vujx538o 13 39 human human JJ cord-274141-vujx538o 13 40 coronavirus- coronavirus- NN cord-274141-vujx538o 14 1 NL63 NL63 NNP cord-274141-vujx538o 15 1 ( ( -LRB- cord-274141-vujx538o 15 2 HCoV HCoV NNP cord-274141-vujx538o 15 3 - - HYPH cord-274141-vujx538o 15 4 NL63 NL63 NNP cord-274141-vujx538o 15 5 ) ) -RRB- cord-274141-vujx538o 15 6 , , , cord-274141-vujx538o 15 7 severe severe JJ cord-274141-vujx538o 15 8 acute acute JJ cord-274141-vujx538o 15 9 respiratory respiratory JJ cord-274141-vujx538o 15 10 syndrome syndrome NN cord-274141-vujx538o 15 11 ( ( -LRB- cord-274141-vujx538o 15 12 SARS)-CoV SARS)-CoV NNP cord-274141-vujx538o 15 13 , , , cord-274141-vujx538o 15 14 and and CC cord-274141-vujx538o 16 1 Middle Middle NNP cord-274141-vujx538o 16 2 East East NNP cord-274141-vujx538o 16 3 respiratory respiratory JJ cord-274141-vujx538o 16 4 syndrome syndrome NN cord-274141-vujx538o 17 1 ( ( -LRB- cord-274141-vujx538o 17 2 MERS)-CoV MERS)-CoV NNP cord-274141-vujx538o 17 3 ( ( -LRB- cord-274141-vujx538o 17 4 Pillaiyar Pillaiyar NNP cord-274141-vujx538o 17 5 et et NNP cord-274141-vujx538o 17 6 al al NNP cord-274141-vujx538o 17 7 . . NNP cord-274141-vujx538o 17 8 2020 2020 CD cord-274141-vujx538o 17 9 ) ) -RRB- cord-274141-vujx538o 17 10 . . . cord-274141-vujx538o 18 1 SARS SARS NNP cord-274141-vujx538o 18 2 is be VBZ cord-274141-vujx538o 18 3 a a DT cord-274141-vujx538o 18 4 highly highly RB cord-274141-vujx538o 18 5 contagious contagious JJ cord-274141-vujx538o 18 6 and and CC cord-274141-vujx538o 18 7 often often RB cord-274141-vujx538o 18 8 fatal fatal JJ cord-274141-vujx538o 18 9 respiratory respiratory JJ cord-274141-vujx538o 18 10 infection infection NN cord-274141-vujx538o 18 11 . . . cord-274141-vujx538o 19 1 HCoV-229E HCoV-229E NNP cord-274141-vujx538o 19 2 , , , cord-274141-vujx538o 19 3 HCoV HCoV NNP cord-274141-vujx538o 19 4 - - HYPH cord-274141-vujx538o 19 5 OC43 OC43 NNP cord-274141-vujx538o 19 6 , , , cord-274141-vujx538o 19 7 HCoV HCoV NNP cord-274141-vujx538o 19 8 - - HYPH cord-274141-vujx538o 19 9 NL63 NL63 NNP cord-274141-vujx538o 19 10 , , , cord-274141-vujx538o 19 11 and and CC cord-274141-vujx538o 19 12 HCoV HCoV NNP cord-274141-vujx538o 19 13 - - HYPH cord-274141-vujx538o 19 14 HKU1 HKU1 NNP cord-274141-vujx538o 19 15 are be VBP cord-274141-vujx538o 19 16 ubiquitous ubiquitous JJ cord-274141-vujx538o 19 17 and and CC cord-274141-vujx538o 19 18 cause cause VB cord-274141-vujx538o 19 19 approximately approximately RB cord-274141-vujx538o 19 20 onethird onethird NN cord-274141-vujx538o 19 21 of of IN cord-274141-vujx538o 19 22 common common JJ cord-274141-vujx538o 19 23 cold cold NN cord-274141-vujx538o 19 24 in in IN cord-274141-vujx538o 19 25 humans human NNS cord-274141-vujx538o 19 26 . . . cord-274141-vujx538o 20 1 HCoV-229E HCoV-229E NNP cord-274141-vujx538o 20 2 , , , cord-274141-vujx538o 20 3 HCoV HCoV NNP cord-274141-vujx538o 20 4 - - HYPH cord-274141-vujx538o 20 5 OC43 OC43 NNP cord-274141-vujx538o 20 6 , , , cord-274141-vujx538o 20 7 HCoV HCoV NNP cord-274141-vujx538o 20 8 - - HYPH cord-274141-vujx538o 20 9 NL63 NL63 NNP cord-274141-vujx538o 20 10 , , , cord-274141-vujx538o 20 11 and and CC cord-274141-vujx538o 20 12 HCoV HCoV NNP cord-274141-vujx538o 20 13 - - HYPH cord-274141-vujx538o 20 14 HKU1 hku1 CD cord-274141-vujx538o 20 15 strains strain NNS cord-274141-vujx538o 20 16 are be VBP cord-274141-vujx538o 20 17 usually usually RB cord-274141-vujx538o 20 18 associated associate VBN cord-274141-vujx538o 20 19 with with IN cord-274141-vujx538o 20 20 mild mild JJ cord-274141-vujx538o 20 21 , , , cord-274141-vujx538o 20 22 self self NN cord-274141-vujx538o 20 23 - - HYPH cord-274141-vujx538o 20 24 limiting limit VBG cord-274141-vujx538o 20 25 upper upper JJ cord-274141-vujx538o 20 26 respiratory respiratory JJ cord-274141-vujx538o 20 27 tract tract NN cord-274141-vujx538o 20 28 infections infection NNS cord-274141-vujx538o 20 29 , , , cord-274141-vujx538o 20 30 such such JJ cord-274141-vujx538o 20 31 as as IN cord-274141-vujx538o 20 32 the the DT cord-274141-vujx538o 20 33 common common JJ cord-274141-vujx538o 20 34 cold cold NN cord-274141-vujx538o 20 35 ( ( -LRB- cord-274141-vujx538o 20 36 Andersen Andersen NNP cord-274141-vujx538o 20 37 et et NNP cord-274141-vujx538o 20 38 al al NNP cord-274141-vujx538o 20 39 . . NNP cord-274141-vujx538o 20 40 2020 2020 CD cord-274141-vujx538o 20 41 ) ) -RRB- cord-274141-vujx538o 20 42 . . . cord-274141-vujx538o 21 1 However however RB cord-274141-vujx538o 21 2 , , , cord-274141-vujx538o 21 3 subtypes subtype NNS cord-274141-vujx538o 21 4 HCoV-229E HCoV-229E NNP cord-274141-vujx538o 21 5 , , , cord-274141-vujx538o 21 6 HCoV HCoV NNP cord-274141-vujx538o 21 7 - - HYPH cord-274141-vujx538o 21 8 OC43 OC43 NNP cord-274141-vujx538o 21 9 , , , cord-274141-vujx538o 21 10 HCoV HCoV NNP cord-274141-vujx538o 21 11 - - HYPH cord-274141-vujx538o 21 12 HKU1 HKU1 NNP cord-274141-vujx538o 21 13 , , , cord-274141-vujx538o 21 14 and and CC cord-274141-vujx538o 21 15 HCoV HCoV NNP cord-274141-vujx538o 21 16 - - HYPH cord-274141-vujx538o 21 17 NL63 NL63 NNP cord-274141-vujx538o 21 18 can can MD cord-274141-vujx538o 21 19 cause cause VB cord-274141-vujx538o 21 20 life life NN cord-274141-vujx538o 21 21 - - HYPH cord-274141-vujx538o 21 22 threatening threaten VBG cord-274141-vujx538o 21 23 pneumonia pneumonia NN cord-274141-vujx538o 21 24 and and CC cord-274141-vujx538o 21 25 bronchitis bronchitis NN cord-274141-vujx538o 21 26 in in IN cord-274141-vujx538o 21 27 the the DT cord-274141-vujx538o 21 28 elderly elderly JJ cord-274141-vujx538o 21 29 and and CC cord-274141-vujx538o 21 30 immunologically immunologically RB cord-274141-vujx538o 21 31 compromised compromised JJ cord-274141-vujx538o 21 32 individuals individual NNS cord-274141-vujx538o 21 33 including include VBG cord-274141-vujx538o 21 34 those those DT cord-274141-vujx538o 21 35 undergoing undergo VBG cord-274141-vujx538o 21 36 chemotherapy chemotherapy NN cord-274141-vujx538o 21 37 and and CC cord-274141-vujx538o 21 38 persons person NNS cord-274141-vujx538o 21 39 living live VBG cord-274141-vujx538o 21 40 with with IN cord-274141-vujx538o 21 41 HIV HIV NNP cord-274141-vujx538o 21 42 / / SYM cord-274141-vujx538o 21 43 AIDS AIDS NNP cord-274141-vujx538o 21 44 . . . cord-274141-vujx538o 22 1 Indeed indeed RB cord-274141-vujx538o 22 2 , , , cord-274141-vujx538o 22 3 before before IN cord-274141-vujx538o 22 4 the the DT cord-274141-vujx538o 22 5 discovery discovery NN cord-274141-vujx538o 22 6 of of IN cord-274141-vujx538o 22 7 SARS SARS NNP cord-274141-vujx538o 22 8 - - HYPH cord-274141-vujx538o 22 9 CoV CoV NNP cord-274141-vujx538o 22 10 , , , cord-274141-vujx538o 22 11 two two CD cord-274141-vujx538o 22 12 coronaviruses coronaviruse NNS cord-274141-vujx538o 22 13 , , , cord-274141-vujx538o 22 14 HCoV-229E HCoV-229E NNP cord-274141-vujx538o 22 15 and and CC cord-274141-vujx538o 22 16 HCoV HCoV NNP cord-274141-vujx538o 22 17 - - HYPH cord-274141-vujx538o 22 18 OC43 OC43 NNP cord-274141-vujx538o 22 19 , , , cord-274141-vujx538o 22 20 were be VBD cord-274141-vujx538o 22 21 known know VBN cord-274141-vujx538o 22 22 to to TO cord-274141-vujx538o 22 23 infect infect VB cord-274141-vujx538o 22 24 humans human NNS cord-274141-vujx538o 22 25 , , , cord-274141-vujx538o 22 26 but but CC cord-274141-vujx538o 22 27 they -PRON- PRP cord-274141-vujx538o 22 28 caused cause VBD cord-274141-vujx538o 22 29 only only RB cord-274141-vujx538o 22 30 selflimiting selflimite VBG cord-274141-vujx538o 22 31 upper upper JJ cord-274141-vujx538o 22 32 respiratory respiratory JJ cord-274141-vujx538o 22 33 tract tract NN cord-274141-vujx538o 22 34 infections infection NNS cord-274141-vujx538o 22 35 ( ( -LRB- cord-274141-vujx538o 22 36 30 30 CD cord-274141-vujx538o 22 37 % % NN cord-274141-vujx538o 22 38 of of IN cord-274141-vujx538o 22 39 the the DT cord-274141-vujx538o 22 40 common common JJ cord-274141-vujx538o 22 41 colds cold NNS cord-274141-vujx538o 22 42 ) ) -RRB- cord-274141-vujx538o 22 43 , , , cord-274141-vujx538o 22 44 and and CC cord-274141-vujx538o 22 45 had have VBD cord-274141-vujx538o 22 46 never never RB cord-274141-vujx538o 22 47 been be VBN cord-274141-vujx538o 22 48 reported report VBN cord-274141-vujx538o 22 49 to to TO cord-274141-vujx538o 22 50 cause cause VB cord-274141-vujx538o 22 51 severe severe JJ cord-274141-vujx538o 22 52 illness illness NN cord-274141-vujx538o 22 53 ( ( -LRB- cord-274141-vujx538o 22 54 Kuba Kuba NNP cord-274141-vujx538o 22 55 et et NNP cord-274141-vujx538o 22 56 al al NNP cord-274141-vujx538o 22 57 . . NNP cord-274141-vujx538o 22 58 2005 2005 CD cord-274141-vujx538o 22 59 ) ) -RRB- cord-274141-vujx538o 22 60 . . . cord-274141-vujx538o 23 1 SARS SARS NNP cord-274141-vujx538o 23 2 - - HYPH cord-274141-vujx538o 23 3 CoV CoV NNP cord-274141-vujx538o 23 4 caused cause VBD cord-274141-vujx538o 23 5 a a DT cord-274141-vujx538o 23 6 global global JJ cord-274141-vujx538o 23 7 epidemic epidemic NN cord-274141-vujx538o 23 8 from from IN cord-274141-vujx538o 23 9 November November NNP cord-274141-vujx538o 23 10 2002 2002 CD cord-274141-vujx538o 23 11 to to IN cord-274141-vujx538o 23 12 2003 2003 CD cord-274141-vujx538o 23 13 ; ; : cord-274141-vujx538o 23 14 about about RB cord-274141-vujx538o 23 15 8422 8422 CD cord-274141-vujx538o 23 16 people people NNS cord-274141-vujx538o 23 17 were be VBD cord-274141-vujx538o 23 18 infected infect VBN cord-274141-vujx538o 23 19 in in IN cord-274141-vujx538o 23 20 32 32 CD cord-274141-vujx538o 23 21 countries country NNS cord-274141-vujx538o 23 22 , , , cord-274141-vujx538o 23 23 916 916 CD cord-274141-vujx538o 23 24 persons person NNS cord-274141-vujx538o 23 25 died die VBD cord-274141-vujx538o 23 26 , , , cord-274141-vujx538o 23 27 and and CC cord-274141-vujx538o 23 28 the the DT cord-274141-vujx538o 23 29 fatality fatality NN cord-274141-vujx538o 23 30 rate rate NN cord-274141-vujx538o 23 31 was be VBD cord-274141-vujx538o 23 32 10 10 CD cord-274141-vujx538o 23 33 - - SYM cord-274141-vujx538o 23 34 15 15 CD cord-274141-vujx538o 23 35 % % NN cord-274141-vujx538o 23 36 . . . cord-274141-vujx538o 24 1 Analysis analysis NN cord-274141-vujx538o 24 2 of of IN cord-274141-vujx538o 24 3 the the DT cord-274141-vujx538o 24 4 full full JJ cord-274141-vujx538o 24 5 sequence sequence NN cord-274141-vujx538o 24 6 of of IN cord-274141-vujx538o 24 7 SARS SARS NNP cord-274141-vujx538o 24 8 - - HYPH cord-274141-vujx538o 24 9 CoV CoV NNP cord-274141-vujx538o 24 10 , , , cord-274141-vujx538o 24 11 which which WDT cord-274141-vujx538o 24 12 is be VBZ cord-274141-vujx538o 24 13 about about RB cord-274141-vujx538o 24 14 29.7 29.7 CD cord-274141-vujx538o 24 15 kb kb NNS cord-274141-vujx538o 24 16 in in IN cord-274141-vujx538o 24 17 length length NN cord-274141-vujx538o 24 18 , , , cord-274141-vujx538o 24 19 reveals reveal VBZ cord-274141-vujx538o 24 20 that that IN cord-274141-vujx538o 24 21 it -PRON- PRP cord-274141-vujx538o 24 22 is be VBZ cord-274141-vujx538o 24 23 a a DT cord-274141-vujx538o 24 24 large large JJ cord-274141-vujx538o 24 25 , , , cord-274141-vujx538o 24 26 single single JJ cord-274141-vujx538o 24 27 - - HYPH cord-274141-vujx538o 24 28 stranded stranded JJ cord-274141-vujx538o 24 29 , , , cord-274141-vujx538o 24 30 positivesense positivesense NNP cord-274141-vujx538o 24 31 RNA RNA NNP cord-274141-vujx538o 24 32 virus virus NN cord-274141-vujx538o 24 33 . . . cord-274141-vujx538o 25 1 In in IN cord-274141-vujx538o 25 2 2013 2013 CD cord-274141-vujx538o 25 3 , , , cord-274141-vujx538o 25 4 MERS MERS NNP cord-274141-vujx538o 25 5 - - HYPH cord-274141-vujx538o 25 6 CoV CoV NNP cord-274141-vujx538o 25 7 also also RB cord-274141-vujx538o 25 8 triggered trigger VBD cord-274141-vujx538o 25 9 an an DT cord-274141-vujx538o 25 10 epidemic epidemic NN cord-274141-vujx538o 25 11 in in IN cord-274141-vujx538o 25 12 the the DT cord-274141-vujx538o 25 13 Middle Middle NNP cord-274141-vujx538o 25 14 East East NNP cord-274141-vujx538o 25 15 and and CC cord-274141-vujx538o 25 16 a a DT cord-274141-vujx538o 25 17 major major JJ cord-274141-vujx538o 25 18 outbreak outbreak NN cord-274141-vujx538o 25 19 in in IN cord-274141-vujx538o 25 20 South South NNP cord-274141-vujx538o 25 21 Korea Korea NNP cord-274141-vujx538o 25 22 occurred occur VBD cord-274141-vujx538o 25 23 in in IN cord-274141-vujx538o 25 24 May May NNP cord-274141-vujx538o 25 25 - - HYPH cord-274141-vujx538o 25 26 June June NNP cord-274141-vujx538o 25 27 2015 2015 CD cord-274141-vujx538o 25 28 ( ( -LRB- cord-274141-vujx538o 25 29 Kim Kim NNP cord-274141-vujx538o 25 30 et et NNP cord-274141-vujx538o 25 31 al al NNP cord-274141-vujx538o 25 32 . . NNP cord-274141-vujx538o 25 33 2017a 2017a CD cord-274141-vujx538o 25 34 ) ) -RRB- cord-274141-vujx538o 25 35 . . . cord-274141-vujx538o 26 1 With with IN cord-274141-vujx538o 26 2 a a DT cord-274141-vujx538o 26 3 case case NN cord-274141-vujx538o 26 4 - - HYPH cord-274141-vujx538o 26 5 fatality fatality NN cord-274141-vujx538o 26 6 rate rate NN cord-274141-vujx538o 26 7 of of IN cord-274141-vujx538o 26 8 35.5 35.5 CD cord-274141-vujx538o 26 9 % % NN cord-274141-vujx538o 26 10 , , , cord-274141-vujx538o 26 11 MERS MERS NNP cord-274141-vujx538o 26 12 - - HYPH cord-274141-vujx538o 26 13 CoV CoV NNP cord-274141-vujx538o 26 14 is be VBZ cord-274141-vujx538o 26 15 heavily heavily RB cord-274141-vujx538o 26 16 endemic endemic JJ cord-274141-vujx538o 26 17 in in IN cord-274141-vujx538o 26 18 dromedary dromedary NN cord-274141-vujx538o 26 19 camels camel NNS cord-274141-vujx538o 26 20 and and CC cord-274141-vujx538o 26 21 causes cause VBZ cord-274141-vujx538o 26 22 lower low JJR cord-274141-vujx538o 26 23 respiratory respiratory JJ cord-274141-vujx538o 26 24 tract tract NN cord-274141-vujx538o 26 25 infections infection NNS cord-274141-vujx538o 26 26 in in IN cord-274141-vujx538o 26 27 humans human NNS cord-274141-vujx538o 27 1 ( ( -LRB- cord-274141-vujx538o 27 2 Kim Kim NNP cord-274141-vujx538o 27 3 et et NNP cord-274141-vujx538o 27 4 al al NNP cord-274141-vujx538o 27 5 . . NNP cord-274141-vujx538o 27 6 2017a 2017a CD cord-274141-vujx538o 27 7 ) ) -RRB- cord-274141-vujx538o 27 8 . . . cord-274141-vujx538o 28 1 Although although IN cord-274141-vujx538o 28 2 the the DT cord-274141-vujx538o 28 3 SARS SARS NNP cord-274141-vujx538o 28 4 - - HYPH cord-274141-vujx538o 28 5 CoV CoV NNP cord-274141-vujx538o 28 6 epidemic epidemic NN cord-274141-vujx538o 28 7 had have VBD cord-274141-vujx538o 28 8 been be VBN cord-274141-vujx538o 28 9 under under IN cord-274141-vujx538o 28 10 control control NN cord-274141-vujx538o 28 11 for for IN cord-274141-vujx538o 28 12 years year NNS cord-274141-vujx538o 28 13 , , , cord-274141-vujx538o 28 14 Wang Wang NNP cord-274141-vujx538o 28 15 et et NNP cord-274141-vujx538o 28 16 al al NNP cord-274141-vujx538o 28 17 . . . cord-274141-vujx538o 29 1 ( ( -LRB- cord-274141-vujx538o 29 2 2017 2017 CD cord-274141-vujx538o 29 3 ) ) -RRB- cord-274141-vujx538o 29 4 warned warn VBD cord-274141-vujx538o 29 5 that that IN cord-274141-vujx538o 29 6 re re NN cord-274141-vujx538o 29 7 - - NN cord-274141-vujx538o 29 8 emergence emergence NN cord-274141-vujx538o 29 9 of of IN cord-274141-vujx538o 29 10 this this DT cord-274141-vujx538o 29 11 threatening threaten VBG cord-274141-vujx538o 29 12 infection infection NN cord-274141-vujx538o 29 13 posed pose VBD cord-274141-vujx538o 29 14 a a DT cord-274141-vujx538o 29 15 possible possible JJ cord-274141-vujx538o 29 16 global global JJ cord-274141-vujx538o 29 17 risk risk NN cord-274141-vujx538o 29 18 as as IN cord-274141-vujx538o 29 19 potentially potentially RB cord-274141-vujx538o 29 20 new new JJ cord-274141-vujx538o 29 21 strains strain NNS cord-274141-vujx538o 29 22 of of IN cord-274141-vujx538o 29 23 SARS SARS NNP cord-274141-vujx538o 29 24 - - HYPH cord-274141-vujx538o 29 25 CoV CoV NNP cord-274141-vujx538o 29 26 would would MD cord-274141-vujx538o 29 27 be be VB cord-274141-vujx538o 29 28 more more RBR cord-274141-vujx538o 29 29 dangerous dangerous JJ cord-274141-vujx538o 29 30 than than IN cord-274141-vujx538o 29 31 the the DT cord-274141-vujx538o 29 32 previous previous JJ cord-274141-vujx538o 29 33 ones one NNS cord-274141-vujx538o 29 34 . . . cord-274141-vujx538o 30 1 Toward toward IN cord-274141-vujx538o 30 2 the the DT cord-274141-vujx538o 30 3 end end NN cord-274141-vujx538o 30 4 of of IN cord-274141-vujx538o 30 5 2019 2019 CD cord-274141-vujx538o 30 6 and and CC cord-274141-vujx538o 30 7 the the DT cord-274141-vujx538o 30 8 beginning beginning NN cord-274141-vujx538o 30 9 of of IN cord-274141-vujx538o 30 10 2020 2020 CD cord-274141-vujx538o 30 11 , , , cord-274141-vujx538o 30 12 multiple multiple JJ cord-274141-vujx538o 30 13 human human JJ cord-274141-vujx538o 30 14 cases case NNS cord-274141-vujx538o 30 15 of of IN cord-274141-vujx538o 30 16 a a DT cord-274141-vujx538o 30 17 new new JJ cord-274141-vujx538o 30 18 viral viral JJ cord-274141-vujx538o 30 19 infection infection NN cord-274141-vujx538o 30 20 were be VBD cord-274141-vujx538o 30 21 reportedly reportedly RB cord-274141-vujx538o 30 22 linked link VBN cord-274141-vujx538o 30 23 to to IN cord-274141-vujx538o 30 24 the the DT cord-274141-vujx538o 30 25 Huanan Huanan NNP cord-274141-vujx538o 30 26 Seafood Seafood NNP cord-274141-vujx538o 30 27 Wholesale Wholesale NNP cord-274141-vujx538o 30 28 " " `` cord-274141-vujx538o 30 29 wet wet JJ cord-274141-vujx538o 30 30 " " '' cord-274141-vujx538o 30 31 Market market NN cord-274141-vujx538o 30 32 ( ( -LRB- cord-274141-vujx538o 30 33 South South NNP cord-274141-vujx538o 30 34 China China NNP cord-274141-vujx538o 30 35 Seafood Seafood NNP cord-274141-vujx538o 30 36 City City NNP cord-274141-vujx538o 30 37 Food Food NNP cord-274141-vujx538o 30 38 Market Market NNP cord-274141-vujx538o 30 39 ) ) -RRB- cord-274141-vujx538o 30 40 in in IN cord-274141-vujx538o 30 41 Wuhan Wuhan NNP cord-274141-vujx538o 30 42 , , , cord-274141-vujx538o 30 43 China China NNP cord-274141-vujx538o 30 44 Zhang Zhang NNP cord-274141-vujx538o 30 45 et et NNP cord-274141-vujx538o 30 46 al al NNP cord-274141-vujx538o 30 47 . . NNP cord-274141-vujx538o 30 48 2020 2020 CD cord-274141-vujx538o 30 49 ) ) -RRB- cord-274141-vujx538o 30 50 . . . cord-274141-vujx538o 31 1 On on IN cord-274141-vujx538o 31 2 7 7 CD cord-274141-vujx538o 31 3 January January NNP cord-274141-vujx538o 31 4 2020 2020 CD cord-274141-vujx538o 31 5 , , , cord-274141-vujx538o 31 6 the the DT cord-274141-vujx538o 31 7 new new JJ cord-274141-vujx538o 31 8 virus virus NN cord-274141-vujx538o 31 9 was be VBD cord-274141-vujx538o 31 10 identified identify VBN cord-274141-vujx538o 31 11 as as IN cord-274141-vujx538o 31 12 a a DT cord-274141-vujx538o 31 13 novel novel JJ cord-274141-vujx538o 31 14 coronavirus coronavirus NN cord-274141-vujx538o 31 15 and and CC cord-274141-vujx538o 31 16 officially officially RB cord-274141-vujx538o 31 17 named name VBN cord-274141-vujx538o 31 18 by by IN cord-274141-vujx538o 31 19 the the DT cord-274141-vujx538o 31 20 World World NNP cord-274141-vujx538o 31 21 Health Health NNP cord-274141-vujx538o 31 22 Organization Organization NNP cord-274141-vujx538o 31 23 as as IN cord-274141-vujx538o 31 24 2019-nCoV 2019-ncov CD cord-274141-vujx538o 31 25 ) ) -RRB- cord-274141-vujx538o 31 26 . . . cord-274141-vujx538o 32 1 On on IN cord-274141-vujx538o 32 2 20 20 CD cord-274141-vujx538o 32 3 January January NNP cord-274141-vujx538o 32 4 2020 2020 CD cord-274141-vujx538o 32 5 , , , cord-274141-vujx538o 32 6 the the DT cord-274141-vujx538o 32 7 National National NNP cord-274141-vujx538o 32 8 Health Health NNP cord-274141-vujx538o 32 9 Commission Commission NNP cord-274141-vujx538o 32 10 of of IN cord-274141-vujx538o 32 11 China China NNP cord-274141-vujx538o 32 12 confirmed confirm VBD cord-274141-vujx538o 32 13 the the DT cord-274141-vujx538o 32 14 human human NN cord-274141-vujx538o 32 15 - - HYPH cord-274141-vujx538o 32 16 to to IN cord-274141-vujx538o 32 17 - - HYPH cord-274141-vujx538o 32 18 human human JJ cord-274141-vujx538o 32 19 transmission transmission NN cord-274141-vujx538o 32 20 of of IN cord-274141-vujx538o 32 21 2019-nCoV 2019-ncov CD cord-274141-vujx538o 32 22 with with IN cord-274141-vujx538o 32 23 its -PRON- PRP$ cord-274141-vujx538o 32 24 presenting present VBG cord-274141-vujx538o 32 25 common common JJ cord-274141-vujx538o 32 26 symptoms symptom NNS cord-274141-vujx538o 32 27 such such JJ cord-274141-vujx538o 32 28 as as IN cord-274141-vujx538o 32 29 fever fever NN cord-274141-vujx538o 32 30 , , , cord-274141-vujx538o 32 31 tiredness tiredness NN cord-274141-vujx538o 32 32 , , , cord-274141-vujx538o 32 33 dry dry JJ cord-274141-vujx538o 32 34 cough cough NN cord-274141-vujx538o 32 35 , , , cord-274141-vujx538o 32 36 shortness shortness NN cord-274141-vujx538o 32 37 of of IN cord-274141-vujx538o 32 38 breath breath NN cord-274141-vujx538o 32 39 , , , cord-274141-vujx538o 32 40 and and CC cord-274141-vujx538o 32 41 pneumonia pneumonia NN cord-274141-vujx538o 32 42 ( ( -LRB- cord-274141-vujx538o 32 43 Elfiky Elfiky NNP cord-274141-vujx538o 32 44 2020 2020 CD cord-274141-vujx538o 32 45 ) ) -RRB- cord-274141-vujx538o 32 46 , , , cord-274141-vujx538o 32 47 and and CC cord-274141-vujx538o 32 48 less less RBR cord-274141-vujx538o 32 49 common common JJ cord-274141-vujx538o 32 50 signs sign NNS cord-274141-vujx538o 32 51 as as IN cord-274141-vujx538o 32 52 diarrhea diarrhea NN cord-274141-vujx538o 32 53 , , , cord-274141-vujx538o 32 54 conjunctivitis conjunctivitis NN cord-274141-vujx538o 32 55 , , , cord-274141-vujx538o 32 56 headache headache NN cord-274141-vujx538o 32 57 , , , cord-274141-vujx538o 32 58 loss loss NN cord-274141-vujx538o 32 59 of of IN cord-274141-vujx538o 32 60 taste taste NN cord-274141-vujx538o 32 61 or or CC cord-274141-vujx538o 32 62 smell smell NN cord-274141-vujx538o 32 63 , , , cord-274141-vujx538o 32 64 and and CC cord-274141-vujx538o 32 65 rash rash VB cord-274141-vujx538o 32 66 on on IN cord-274141-vujx538o 32 67 skin skin NN cord-274141-vujx538o 32 68 or or CC cord-274141-vujx538o 32 69 discoloration discoloration NN cord-274141-vujx538o 32 70 of of IN cord-274141-vujx538o 32 71 fingers finger NNS cord-274141-vujx538o 32 72 and and CC cord-274141-vujx538o 32 73 toes toe NNS cord-274141-vujx538o 32 74 . . . cord-274141-vujx538o 33 1 The the DT cord-274141-vujx538o 33 2 World World NNP cord-274141-vujx538o 33 3 Health Health NNP cord-274141-vujx538o 33 4 Organization Organization NNP cord-274141-vujx538o 33 5 also also RB cord-274141-vujx538o 33 6 recognized recognize VBD cord-274141-vujx538o 33 7 2019-nCoV 2019-ncov CD cord-274141-vujx538o 33 8 as as IN cord-274141-vujx538o 33 9 the the DT cord-274141-vujx538o 33 10 causative causative JJ cord-274141-vujx538o 33 11 agent agent NN cord-274141-vujx538o 33 12 of of IN cord-274141-vujx538o 33 13 the the DT cord-274141-vujx538o 33 14 coronavirus coronavirus NN cord-274141-vujx538o 33 15 disease disease NN cord-274141-vujx538o 33 16 2019 2019 CD cord-274141-vujx538o 33 17 . . . cord-274141-vujx538o 34 1 The the DT cord-274141-vujx538o 34 2 2019-nCoV 2019-ncov CD cord-274141-vujx538o 34 3 was be VBD cord-274141-vujx538o 34 4 later later RB cord-274141-vujx538o 34 5 named name VBN cord-274141-vujx538o 34 6 severe severe JJ cord-274141-vujx538o 34 7 acute acute JJ cord-274141-vujx538o 34 8 respiratory respiratory JJ cord-274141-vujx538o 34 9 syndrome syndrome NN cord-274141-vujx538o 34 10 coronavirus coronavirus NN cord-274141-vujx538o 34 11 2 2 CD cord-274141-vujx538o 35 1 ( ( -LRB- cord-274141-vujx538o 35 2 SARS SARS NNP cord-274141-vujx538o 35 3 - - HYPH cord-274141-vujx538o 35 4 CoV-2 CoV-2 NNP cord-274141-vujx538o 35 5 ) ) -RRB- cord-274141-vujx538o 35 6 by by IN cord-274141-vujx538o 35 7 the the DT cord-274141-vujx538o 35 8 International International NNP cord-274141-vujx538o 35 9 Committee Committee NNP cord-274141-vujx538o 35 10 on on IN cord-274141-vujx538o 35 11 Taxonomy Taxonomy NNP cord-274141-vujx538o 35 12 of of IN cord-274141-vujx538o 35 13 Viruses Viruses NNPS cord-274141-vujx538o 35 14 , , , cord-274141-vujx538o 35 15 Coronaviridae Coronaviridae NNP cord-274141-vujx538o 35 16 Study Study NNP cord-274141-vujx538o 35 17 Group Group NNP cord-274141-vujx538o 35 18 ( ( -LRB- cord-274141-vujx538o 35 19 Ling Ling NNP cord-274141-vujx538o 35 20 2020 2020 CD cord-274141-vujx538o 35 21 ) ) -RRB- cord-274141-vujx538o 35 22 . . . cord-274141-vujx538o 36 1 A a DT cord-274141-vujx538o 36 2 phylogenetic phylogenetic JJ cord-274141-vujx538o 36 3 analysis analysis NN cord-274141-vujx538o 36 4 found find VBD cord-274141-vujx538o 36 5 a a DT cord-274141-vujx538o 36 6 bat bat NN cord-274141-vujx538o 36 7 origin origin NN cord-274141-vujx538o 36 8 for for IN cord-274141-vujx538o 36 9 the the DT cord-274141-vujx538o 36 10 SARS SARS NNP cord-274141-vujx538o 36 11 - - HYPH cord-274141-vujx538o 36 12 CoV-2 CoV-2 NNP cord-274141-vujx538o 37 1 ( ( -LRB- cord-274141-vujx538o 37 2 Lu Lu NNP cord-274141-vujx538o 37 3 et et FW cord-274141-vujx538o 37 4 al al NNP cord-274141-vujx538o 37 5 . . NNP cord-274141-vujx538o 37 6 2020 2020 CD cord-274141-vujx538o 37 7 ; ; . cord-274141-vujx538o 38 1 Wan Wan NNP cord-274141-vujx538o 38 2 et et NNP cord-274141-vujx538o 38 3 al al NNP cord-274141-vujx538o 38 4 . . NNP cord-274141-vujx538o 38 5 2020 2020 CD cord-274141-vujx538o 38 6 ) ) -RRB- cord-274141-vujx538o 38 7 . . . cord-274141-vujx538o 39 1 Yang Yang NNP cord-274141-vujx538o 39 2 et et NNP cord-274141-vujx538o 39 3 al al NNP cord-274141-vujx538o 39 4 . . . cord-274141-vujx538o 40 1 ( ( -LRB- cord-274141-vujx538o 40 2 2020 2020 CD cord-274141-vujx538o 40 3 ) ) -RRB- cord-274141-vujx538o 40 4 reported report VBD cord-274141-vujx538o 40 5 that that IN cord-274141-vujx538o 40 6 SARS SARS NNP cord-274141-vujx538o 40 7 - - HYPH cord-274141-vujx538o 40 8 CoV-2 CoV-2 NNP cord-274141-vujx538o 40 9 , , , cord-274141-vujx538o 40 10 formerly formerly RB cord-274141-vujx538o 40 11 known know VBN cord-274141-vujx538o 40 12 as as IN cord-274141-vujx538o 40 13 2019-nCoV 2019-ncov CD cord-274141-vujx538o 40 14 , , , cord-274141-vujx538o 40 15 the the DT cord-274141-vujx538o 40 16 causative causative JJ cord-274141-vujx538o 40 17 pathogen pathogen NN cord-274141-vujx538o 40 18 of of IN cord-274141-vujx538o 40 19 COVID-19 COVID-19 NNP cord-274141-vujx538o 40 20 , , , cord-274141-vujx538o 40 21 had have VBD cord-274141-vujx538o 40 22 rapidly rapidly RB cord-274141-vujx538o 40 23 spread spread VBN cord-274141-vujx538o 40 24 across across IN cord-274141-vujx538o 40 25 China China NNP cord-274141-vujx538o 40 26 and and CC cord-274141-vujx538o 40 27 around around IN cord-274141-vujx538o 40 28 the the DT cord-274141-vujx538o 40 29 world world NN cord-274141-vujx538o 40 30 , , , cord-274141-vujx538o 40 31 causing cause VBG cord-274141-vujx538o 40 32 an an DT cord-274141-vujx538o 40 33 outbreak outbreak NN cord-274141-vujx538o 40 34 of of IN cord-274141-vujx538o 40 35 acute acute JJ cord-274141-vujx538o 40 36 infectious infectious JJ cord-274141-vujx538o 40 37 pneumonia pneumonia NN cord-274141-vujx538o 40 38 . . . cord-274141-vujx538o 41 1 The the DT cord-274141-vujx538o 41 2 spread spread NN cord-274141-vujx538o 41 3 of of IN cord-274141-vujx538o 41 4 SARS SARS NNP cord-274141-vujx538o 41 5 - - HYPH cord-274141-vujx538o 41 6 CoV-2 CoV-2 NNP cord-274141-vujx538o 41 7 , , , cord-274141-vujx538o 41 8 a a DT cord-274141-vujx538o 41 9 new new JJ cord-274141-vujx538o 41 10 highly highly RB cord-274141-vujx538o 41 11 contagious contagious JJ cord-274141-vujx538o 41 12 and and CC cord-274141-vujx538o 41 13 lethal lethal JJ cord-274141-vujx538o 41 14 strain strain NN cord-274141-vujx538o 41 15 of of IN cord-274141-vujx538o 41 16 HCoVs HCoVs NNP cord-274141-vujx538o 41 17 , , , cord-274141-vujx538o 41 18 has have VBZ cord-274141-vujx538o 41 19 now now RB cord-274141-vujx538o 41 20 caused cause VBN cord-274141-vujx538o 41 21 a a DT cord-274141-vujx538o 41 22 global global JJ cord-274141-vujx538o 41 23 pandemic pandemic NN cord-274141-vujx538o 41 24 ( ( -LRB- cord-274141-vujx538o 41 25 Remuzzi Remuzzi NNP cord-274141-vujx538o 41 26 and and CC cord-274141-vujx538o 41 27 Remuzzi Remuzzi NNP cord-274141-vujx538o 41 28 2020 2020 CD cord-274141-vujx538o 41 29 ) ) -RRB- cord-274141-vujx538o 41 30 . . . cord-274141-vujx538o 42 1 In in IN cord-274141-vujx538o 42 2 the the DT cord-274141-vujx538o 42 3 morning morning NN cord-274141-vujx538o 42 4 of of IN cord-274141-vujx538o 42 5 7 7 CD cord-274141-vujx538o 42 6 September September NNP cord-274141-vujx538o 42 7 2020 2020 CD cord-274141-vujx538o 42 8 , , , cord-274141-vujx538o 42 9 Johns Johns NNP cord-274141-vujx538o 42 10 Hopkins Hopkins NNP cord-274141-vujx538o 42 11 University University NNP cord-274141-vujx538o 42 12 reported report VBD cord-274141-vujx538o 42 13 that that IN cord-274141-vujx538o 42 14 there there EX cord-274141-vujx538o 42 15 were be VBD cord-274141-vujx538o 42 16 over over IN cord-274141-vujx538o 42 17 26,994,442 26,994,442 CD cord-274141-vujx538o 42 18 total total NN cord-274141-vujx538o 42 19 confirmed confirm VBN cord-274141-vujx538o 42 20 cases case NNS cord-274141-vujx538o 42 21 and and CC cord-274141-vujx538o 42 22 880,994 880,994 CD cord-274141-vujx538o 42 23 deaths death NNS cord-274141-vujx538o 42 24 globally globally RB cord-274141-vujx538o 42 25 ; ; : cord-274141-vujx538o 42 26 over over IN cord-274141-vujx538o 42 27 6,189,488 6,189,488 CD cord-274141-vujx538o 42 28 cases case NNS cord-274141-vujx538o 42 29 and and CC cord-274141-vujx538o 42 30 187,541 187,541 CD cord-274141-vujx538o 42 31 deaths death NNS cord-274141-vujx538o 42 32 were be VBD cord-274141-vujx538o 42 33 in in IN cord-274141-vujx538o 42 34 the the DT cord-274141-vujx538o 42 35 United United NNP cord-274141-vujx538o 42 36 States States NNP cord-274141-vujx538o 42 37 of of IN cord-274141-vujx538o 42 38 America America NNP cord-274141-vujx538o 42 39 ( ( -LRB- cord-274141-vujx538o 42 40 USA USA NNP cord-274141-vujx538o 42 41 ) ) -RRB- cord-274141-vujx538o 42 42 . . . cord-274141-vujx538o 43 1 COVID-19 COVID-19 NNP cord-274141-vujx538o 43 2 has have VBZ cord-274141-vujx538o 43 3 spread spread VBN cord-274141-vujx538o 43 4 more more RBR cord-274141-vujx538o 43 5 rapidly rapidly RB cord-274141-vujx538o 43 6 due due JJ cord-274141-vujx538o 43 7 to to IN cord-274141-vujx538o 43 8 increased increase VBN cord-274141-vujx538o 43 9 global global JJ cord-274141-vujx538o 43 10 travel travel NN cord-274141-vujx538o 43 11 and and CC cord-274141-vujx538o 43 12 adaptation adaptation NN cord-274141-vujx538o 43 13 of of IN cord-274141-vujx538o 43 14 SARS SARS NNP cord-274141-vujx538o 43 15 - - HYPH cord-274141-vujx538o 43 16 CoV-2 CoV-2 NNP cord-274141-vujx538o 43 17 in in IN cord-274141-vujx538o 43 18 every every DT cord-274141-vujx538o 43 19 environment environment NN cord-274141-vujx538o 43 20 ( ( -LRB- cord-274141-vujx538o 43 21 Vellingiri Vellingiri NNP cord-274141-vujx538o 43 22 et et NNP cord-274141-vujx538o 43 23 al al NNP cord-274141-vujx538o 43 24 . . NNP cord-274141-vujx538o 43 25 2020 2020 CD cord-274141-vujx538o 43 26 ) ) -RRB- cord-274141-vujx538o 43 27 . . . cord-274141-vujx538o 44 1 Currently currently RB cord-274141-vujx538o 44 2 , , , cord-274141-vujx538o 44 3 the the DT cord-274141-vujx538o 44 4 seven seven CD cord-274141-vujx538o 44 5 identified identify VBN cord-274141-vujx538o 44 6 human human JJ cord-274141-vujx538o 44 7 coronaviruses coronaviruse NNS cord-274141-vujx538o 44 8 ( ( -LRB- cord-274141-vujx538o 44 9 HCoVs HCoVs NNP cord-274141-vujx538o 44 10 ) ) -RRB- cord-274141-vujx538o 44 11 are be VBP cord-274141-vujx538o 44 12 SARS SARS NNP cord-274141-vujx538o 44 13 - - HYPH cord-274141-vujx538o 44 14 CoV-2 CoV-2 NNP cord-274141-vujx538o 44 15 , , , cord-274141-vujx538o 44 16 MERS MERS NNP cord-274141-vujx538o 44 17 - - HYPH cord-274141-vujx538o 44 18 CoV CoV NNP cord-274141-vujx538o 44 19 , , , cord-274141-vujx538o 44 20 SARS SARS NNP cord-274141-vujx538o 44 21 - - HYPH cord-274141-vujx538o 44 22 CoV CoV NNP cord-274141-vujx538o 44 23 , , , cord-274141-vujx538o 44 24 HCoV-229E HCoV-229E NNP cord-274141-vujx538o 44 25 , , , cord-274141-vujx538o 44 26 HCoV HCoV NNP cord-274141-vujx538o 44 27 - - HYPH cord-274141-vujx538o 44 28 OC43 OC43 NNP cord-274141-vujx538o 44 29 , , , cord-274141-vujx538o 44 30 HCoV HCoV NNP cord-274141-vujx538o 44 31 - - HYPH cord-274141-vujx538o 44 32 NL63 NL63 NNP cord-274141-vujx538o 44 33 , , , cord-274141-vujx538o 44 34 and and CC cord-274141-vujx538o 44 35 HCoV HCoV NNP cord-274141-vujx538o 44 36 - - HYPH cord-274141-vujx538o 44 37 HKU1 HKU1 NNP cord-274141-vujx538o 44 38 strains strain NNS cord-274141-vujx538o 45 1 ( ( -LRB- cord-274141-vujx538o 45 2 Andersen Andersen NNP cord-274141-vujx538o 45 3 et et NNP cord-274141-vujx538o 45 4 al al NNP cord-274141-vujx538o 45 5 . . NNP cord-274141-vujx538o 45 6 2020 2020 CD cord-274141-vujx538o 45 7 ) ) -RRB- cord-274141-vujx538o 45 8 . . . cord-274141-vujx538o 46 1 Molecular molecular JJ cord-274141-vujx538o 46 2 evolutionary evolutionary JJ cord-274141-vujx538o 46 3 analysis analysis NN cord-274141-vujx538o 46 4 shows show VBZ cord-274141-vujx538o 46 5 that that IN cord-274141-vujx538o 46 6 all all DT cord-274141-vujx538o 46 7 HCoVs hcovs CD cord-274141-vujx538o 46 8 originate originate VBP cord-274141-vujx538o 46 9 in in IN cord-274141-vujx538o 46 10 animals animal NNS cord-274141-vujx538o 46 11 ; ; : cord-274141-vujx538o 46 12 SARS SARS NNP cord-274141-vujx538o 46 13 - - HYPH cord-274141-vujx538o 46 14 CoV CoV NNP cord-274141-vujx538o 46 15 , , , cord-274141-vujx538o 46 16 MERS MERS NNP cord-274141-vujx538o 46 17 - - HYPH cord-274141-vujx538o 46 18 CoV CoV NNP cord-274141-vujx538o 46 19 , , , cord-274141-vujx538o 46 20 HCoV HCoV NNP cord-274141-vujx538o 46 21 - - HYPH cord-274141-vujx538o 46 22 NL63 NL63 NNP cord-274141-vujx538o 46 23 , , , cord-274141-vujx538o 46 24 and and CC cord-274141-vujx538o 46 25 HCoV-229E HCoV-229E NNP cord-274141-vujx538o 46 26 are be VBP cord-274141-vujx538o 46 27 derived derive VBN cord-274141-vujx538o 46 28 from from IN cord-274141-vujx538o 46 29 bats bat NNS cord-274141-vujx538o 46 30 ; ; : cord-274141-vujx538o 46 31 HCoV HCoV NNP cord-274141-vujx538o 46 32 - - HYPH cord-274141-vujx538o 46 33 OC43 OC43 NNP cord-274141-vujx538o 46 34 and and CC cord-274141-vujx538o 46 35 HCoV HCoV NNP cord-274141-vujx538o 46 36 - - HYPH cord-274141-vujx538o 46 37 HKU1 HKU1 NNP cord-274141-vujx538o 46 38 are be VBP cord-274141-vujx538o 46 39 sourced source VBN cord-274141-vujx538o 46 40 from from IN cord-274141-vujx538o 46 41 rodents rodent NNS cord-274141-vujx538o 46 42 ( ( -LRB- cord-274141-vujx538o 46 43 Forni Forni NNP cord-274141-vujx538o 46 44 et et NNP cord-274141-vujx538o 46 45 al al NNP cord-274141-vujx538o 46 46 . . . cord-274141-vujx538o 46 47 2017 2017 CD cord-274141-vujx538o 46 48 ) ) -RRB- cord-274141-vujx538o 46 49 . . . cord-274141-vujx538o 47 1 The the DT cord-274141-vujx538o 47 2 229E 229e CD cord-274141-vujx538o 47 3 and and CC cord-274141-vujx538o 47 4 NL63 NL63 NNP cord-274141-vujx538o 47 5 strains strain NNS cord-274141-vujx538o 47 6 of of IN cord-274141-vujx538o 47 7 HCoVs HCoVs NNP cord-274141-vujx538o 47 8 belong belong VBP cord-274141-vujx538o 47 9 to to IN cord-274141-vujx538o 47 10 alpha alpha NN cord-274141-vujx538o 47 11 coronaviruses coronaviruse NNS cord-274141-vujx538o 47 12 while while IN cord-274141-vujx538o 47 13 OC43 OC43 NNP cord-274141-vujx538o 47 14 , , , cord-274141-vujx538o 47 15 HKU1 HKU1 NNP cord-274141-vujx538o 47 16 , , , cord-274141-vujx538o 47 17 SARS SARS NNP cord-274141-vujx538o 47 18 , , , cord-274141-vujx538o 47 19 MERS MERS NNP cord-274141-vujx538o 47 20 , , , cord-274141-vujx538o 47 21 and and CC cord-274141-vujx538o 47 22 SARS SARS NNP cord-274141-vujx538o 47 23 - - HYPH cord-274141-vujx538o 47 24 CoV-2 CoV-2 NNP cord-274141-vujx538o 47 25 belong belong VBP cord-274141-vujx538o 47 26 to to IN cord-274141-vujx538o 47 27 beta beta NN cord-274141-vujx538o 47 28 coronaviruses coronaviruse NNS cord-274141-vujx538o 47 29 ( ( -LRB- cord-274141-vujx538o 47 30 Elfiky Elfiky NNP cord-274141-vujx538o 47 31 2020 2020 CD cord-274141-vujx538o 47 32 ) ) -RRB- cord-274141-vujx538o 47 33 . . . cord-274141-vujx538o 48 1 Most Most JJS cord-274141-vujx538o 48 2 people people NNS cord-274141-vujx538o 48 3 infected infect VBN cord-274141-vujx538o 48 4 with with IN cord-274141-vujx538o 48 5 SARS SARS NNP cord-274141-vujx538o 48 6 - - HYPH cord-274141-vujx538o 48 7 CoV CoV NNP cord-274141-vujx538o 48 8 , , , cord-274141-vujx538o 48 9 MERS MERS NNP cord-274141-vujx538o 48 10 - - HYPH cord-274141-vujx538o 48 11 CoV CoV NNP cord-274141-vujx538o 48 12 , , , cord-274141-vujx538o 48 13 and and CC cord-274141-vujx538o 48 14 SARS SARS NNP cord-274141-vujx538o 48 15 - - HYPH cord-274141-vujx538o 48 16 CoV-2 CoV-2 NNP cord-274141-vujx538o 48 17 present present JJ cord-274141-vujx538o 48 18 with with IN cord-274141-vujx538o 48 19 severe severe JJ cord-274141-vujx538o 48 20 respiratory respiratory JJ cord-274141-vujx538o 48 21 distress distress NN cord-274141-vujx538o 48 22 , , , cord-274141-vujx538o 48 23 and and CC cord-274141-vujx538o 48 24 many many JJ cord-274141-vujx538o 48 25 of of IN cord-274141-vujx538o 48 26 the the DT cord-274141-vujx538o 48 27 infected infected JJ cord-274141-vujx538o 48 28 succumb succumb VBP cord-274141-vujx538o 48 29 to to IN cord-274141-vujx538o 48 30 coronavirus coronavirus NN cord-274141-vujx538o 48 31 infection infection NN cord-274141-vujx538o 49 1 ( ( -LRB- cord-274141-vujx538o 49 2 Andersen Andersen NNP cord-274141-vujx538o 49 3 et et NNP cord-274141-vujx538o 49 4 al al NNP cord-274141-vujx538o 49 5 . . NNP cord-274141-vujx538o 49 6 2020 2020 CD cord-274141-vujx538o 49 7 ) ) -RRB- cord-274141-vujx538o 49 8 . . . cord-274141-vujx538o 50 1 Pillaiyar Pillaiyar NNP cord-274141-vujx538o 50 2 et et NNP cord-274141-vujx538o 50 3 al al NNP cord-274141-vujx538o 50 4 . . . cord-274141-vujx538o 51 1 ( ( -LRB- cord-274141-vujx538o 51 2 2020 2020 CD cord-274141-vujx538o 51 3 ) ) -RRB- cord-274141-vujx538o 51 4 reviewed review VBD cord-274141-vujx538o 51 5 recent recent JJ cord-274141-vujx538o 51 6 developments development NNS cord-274141-vujx538o 51 7 in in IN cord-274141-vujx538o 51 8 the the DT cord-274141-vujx538o 51 9 discovery discovery NN cord-274141-vujx538o 51 10 and and CC cord-274141-vujx538o 51 11 development development NN cord-274141-vujx538o 51 12 of of IN cord-274141-vujx538o 51 13 synthetic synthetic JJ cord-274141-vujx538o 51 14 drugs drug NNS cord-274141-vujx538o 51 15 to to TO cord-274141-vujx538o 51 16 treat treat VB cord-274141-vujx538o 51 17 HCoVs HCoVs NNP cord-274141-vujx538o 51 18 . . . cord-274141-vujx538o 52 1 However however RB cord-274141-vujx538o 52 2 , , , cord-274141-vujx538o 52 3 these these DT cord-274141-vujx538o 52 4 drugs drug NNS cord-274141-vujx538o 52 5 have have VBP cord-274141-vujx538o 52 6 not not RB cord-274141-vujx538o 52 7 achieved achieve VBN cord-274141-vujx538o 52 8 extended extended JJ cord-274141-vujx538o 52 9 distribution distribution NN cord-274141-vujx538o 52 10 for for IN cord-274141-vujx538o 52 11 clinical clinical JJ cord-274141-vujx538o 52 12 application application NN cord-274141-vujx538o 52 13 because because IN cord-274141-vujx538o 52 14 they -PRON- PRP cord-274141-vujx538o 52 15 have have VBP cord-274141-vujx538o 52 16 not not RB cord-274141-vujx538o 52 17 yet yet RB cord-274141-vujx538o 52 18 been be VBN cord-274141-vujx538o 52 19 tested test VBN cord-274141-vujx538o 52 20 in in IN cord-274141-vujx538o 52 21 rigorous rigorous JJ cord-274141-vujx538o 52 22 randomized randomized JJ cord-274141-vujx538o 52 23 controlled control VBN cord-274141-vujx538o 52 24 clinical clinical JJ cord-274141-vujx538o 52 25 trials trial NNS cord-274141-vujx538o 52 26 ( ( -LRB- cord-274141-vujx538o 52 27 Ford Ford NNP cord-274141-vujx538o 52 28 et et NNP cord-274141-vujx538o 52 29 al al NNP cord-274141-vujx538o 52 30 . . NNP cord-274141-vujx538o 52 31 2020 2020 CD cord-274141-vujx538o 52 32 ) ) -RRB- cord-274141-vujx538o 52 33 . . . cord-274141-vujx538o 53 1 Zhou Zhou NNP cord-274141-vujx538o 53 2 et et NNP cord-274141-vujx538o 53 3 al al NNP cord-274141-vujx538o 53 4 . . . cord-274141-vujx538o 54 1 ( ( -LRB- cord-274141-vujx538o 54 2 2020a 2020a NNS cord-274141-vujx538o 54 3 , , , cord-274141-vujx538o 54 4 b b LS cord-274141-vujx538o 54 5 ) ) -RRB- cord-274141-vujx538o 54 6 reported report VBD cord-274141-vujx538o 54 7 that that IN cord-274141-vujx538o 54 8 there there EX cord-274141-vujx538o 54 9 were be VBD cord-274141-vujx538o 54 10 no no DT cord-274141-vujx538o 54 11 effective effective JJ cord-274141-vujx538o 54 12 drugs drug NNS cord-274141-vujx538o 54 13 targeting target VBG cord-274141-vujx538o 54 14 SARS SARS NNP cord-274141-vujx538o 54 15 - - HYPH cord-274141-vujx538o 54 16 CoV-2 CoV-2 NNP cord-274141-vujx538o 54 17 . . . cord-274141-vujx538o 55 1 Yang Yang NNP cord-274141-vujx538o 55 2 et et NNP cord-274141-vujx538o 55 3 al al NNP cord-274141-vujx538o 55 4 . . . cord-274141-vujx538o 56 1 ( ( -LRB- cord-274141-vujx538o 56 2 2020 2020 CD cord-274141-vujx538o 56 3 ) ) -RRB- cord-274141-vujx538o 56 4 also also RB cord-274141-vujx538o 56 5 stated state VBD cord-274141-vujx538o 56 6 no no DT cord-274141-vujx538o 56 7 efficacious efficacious JJ cord-274141-vujx538o 56 8 and and CC cord-274141-vujx538o 56 9 safe safe JJ cord-274141-vujx538o 56 10 antiviral antiviral JJ cord-274141-vujx538o 56 11 drugs drug NNS cord-274141-vujx538o 56 12 or or CC cord-274141-vujx538o 56 13 vaccines vaccine NNS cord-274141-vujx538o 56 14 were be VBD cord-274141-vujx538o 56 15 available available JJ cord-274141-vujx538o 56 16 for for IN cord-274141-vujx538o 56 17 the the DT cord-274141-vujx538o 56 18 treatment treatment NN cord-274141-vujx538o 56 19 of of IN cord-274141-vujx538o 56 20 this this DT cord-274141-vujx538o 56 21 sudden sudden JJ cord-274141-vujx538o 56 22 and and CC cord-274141-vujx538o 56 23 lethal lethal JJ cord-274141-vujx538o 56 24 disease disease NN cord-274141-vujx538o 56 25 . . . cord-274141-vujx538o 57 1 Supportive supportive JJ cord-274141-vujx538o 57 2 care care NN cord-274141-vujx538o 57 3 and and CC cord-274141-vujx538o 57 4 non non JJ cord-274141-vujx538o 57 5 - - JJ cord-274141-vujx538o 57 6 specific specific JJ cord-274141-vujx538o 57 7 treatment treatment NN cord-274141-vujx538o 57 8 to to TO cord-274141-vujx538o 57 9 ameliorate ameliorate VB cord-274141-vujx538o 57 10 COVID-19 covid-19 JJ cord-274141-vujx538o 57 11 symptoms symptom NNS cord-274141-vujx538o 57 12 of of IN cord-274141-vujx538o 57 13 the the DT cord-274141-vujx538o 57 14 patient patient NN cord-274141-vujx538o 57 15 are be VBP cord-274141-vujx538o 57 16 the the DT cord-274141-vujx538o 57 17 main main JJ cord-274141-vujx538o 57 18 options option NNS cord-274141-vujx538o 57 19 available available JJ cord-274141-vujx538o 57 20 . . . cord-274141-vujx538o 58 1 Remdesivir Remdesivir NNP cord-274141-vujx538o 58 2 , , , cord-274141-vujx538o 58 3 produced produce VBN cord-274141-vujx538o 58 4 by by IN cord-274141-vujx538o 58 5 the the DT cord-274141-vujx538o 58 6 company company NN cord-274141-vujx538o 58 7 Gilead Gilead NNP cord-274141-vujx538o 58 8 , , , cord-274141-vujx538o 58 9 shows show VBZ cord-274141-vujx538o 58 10 EC EC NNP cord-274141-vujx538o 58 11 90 90 CD cord-274141-vujx538o 58 12 of of IN cord-274141-vujx538o 58 13 1.76 1.76 CD cord-274141-vujx538o 58 14 μM μm NN cord-274141-vujx538o 58 15 against against IN cord-274141-vujx538o 58 16 SARS SARS NNP cord-274141-vujx538o 58 17 - - HYPH cord-274141-vujx538o 58 18 CoV-2 CoV-2 NNP cord-274141-vujx538o 59 1 in in IN cord-274141-vujx538o 59 2 vitro vitro FW cord-274141-vujx538o 59 3 ( ( -LRB- cord-274141-vujx538o 59 4 Elfiky Elfiky NNP cord-274141-vujx538o 59 5 2020 2020 CD cord-274141-vujx538o 59 6 ) ) -RRB- cord-274141-vujx538o 59 7 . . . cord-274141-vujx538o 60 1 On on IN cord-274141-vujx538o 60 2 1 1 CD cord-274141-vujx538o 60 3 May May NNP cord-274141-vujx538o 60 4 2020 2020 CD cord-274141-vujx538o 60 5 , , , cord-274141-vujx538o 60 6 remdesivir remdesivir NNP cord-274141-vujx538o 60 7 was be VBD cord-274141-vujx538o 60 8 granted grant VBN cord-274141-vujx538o 60 9 approval approval NN cord-274141-vujx538o 60 10 by by IN cord-274141-vujx538o 60 11 the the DT cord-274141-vujx538o 60 12 US US NNP cord-274141-vujx538o 60 13 Food Food NNP cord-274141-vujx538o 60 14 and and CC cord-274141-vujx538o 60 15 Drug Drug NNP cord-274141-vujx538o 60 16 Administration Administration NNP cord-274141-vujx538o 60 17 for for IN cord-274141-vujx538o 60 18 emergency emergency NN cord-274141-vujx538o 60 19 use use NN cord-274141-vujx538o 60 20 in in IN cord-274141-vujx538o 60 21 the the DT cord-274141-vujx538o 60 22 treatment treatment NN cord-274141-vujx538o 60 23 of of IN cord-274141-vujx538o 60 24 COVID-19 covid-19 JJ cord-274141-vujx538o 60 25 patients patient NNS cord-274141-vujx538o 60 26 . . . cord-274141-vujx538o 61 1 An an DT cord-274141-vujx538o 61 2 inhibitor inhibitor NN cord-274141-vujx538o 61 3 of of IN cord-274141-vujx538o 61 4 the the DT cord-274141-vujx538o 61 5 enzyme enzyme NN cord-274141-vujx538o 61 6 RNAdependent RNAdependent NNP cord-274141-vujx538o 61 7 RNA RNA NNP cord-274141-vujx538o 61 8 polymerase polymerase NN cord-274141-vujx538o 61 9 ( ( -LRB- cord-274141-vujx538o 61 10 RdRp RdRp NNP cord-274141-vujx538o 61 11 ) ) -RRB- cord-274141-vujx538o 61 12 involved involve VBN cord-274141-vujx538o 61 13 in in IN cord-274141-vujx538o 61 14 HCoV HCoV NNP cord-274141-vujx538o 61 15 replication replication NN cord-274141-vujx538o 61 16 , , , cord-274141-vujx538o 61 17 the the DT cord-274141-vujx538o 61 18 drug drug NN cord-274141-vujx538o 61 19 reduced reduce VBN cord-274141-vujx538o 61 20 mortality mortality NN cord-274141-vujx538o 61 21 from from IN cord-274141-vujx538o 61 22 11 11 CD cord-274141-vujx538o 61 23 to to TO cord-274141-vujx538o 61 24 8 8 CD cord-274141-vujx538o 61 25 % % NN cord-274141-vujx538o 61 26 and and CC cord-274141-vujx538o 61 27 duration duration NN cord-274141-vujx538o 61 28 of of IN cord-274141-vujx538o 61 29 symptoms symptom NNS cord-274141-vujx538o 61 30 from from IN cord-274141-vujx538o 61 31 15 15 CD cord-274141-vujx538o 61 32 to to TO cord-274141-vujx538o 61 33 11 11 CD cord-274141-vujx538o 61 34 days day NNS cord-274141-vujx538o 61 35 . . . cord-274141-vujx538o 62 1 However however RB cord-274141-vujx538o 62 2 , , , cord-274141-vujx538o 62 3 in in IN cord-274141-vujx538o 62 4 comparison comparison NN cord-274141-vujx538o 62 5 with with IN cord-274141-vujx538o 62 6 the the DT cord-274141-vujx538o 62 7 placebo placebo NN cord-274141-vujx538o 62 8 , , , cord-274141-vujx538o 62 9 remdesivir remdesivir NNP cord-274141-vujx538o 62 10 's 's POS cord-274141-vujx538o 62 11 reduction reduction NN cord-274141-vujx538o 62 12 of of IN cord-274141-vujx538o 62 13 patient patient JJ cord-274141-vujx538o 62 14 mortality mortality NN cord-274141-vujx538o 62 15 was be VBD cord-274141-vujx538o 62 16 not not RB cord-274141-vujx538o 62 17 significantly significantly RB cord-274141-vujx538o 62 18 different different JJ cord-274141-vujx538o 62 19 . . . cord-274141-vujx538o 63 1 Due due IN cord-274141-vujx538o 63 2 to to IN cord-274141-vujx538o 63 3 the the DT cord-274141-vujx538o 63 4 absence absence NN cord-274141-vujx538o 63 5 of of IN cord-274141-vujx538o 63 6 conventional conventional JJ cord-274141-vujx538o 63 7 therapies therapy NNS cord-274141-vujx538o 63 8 , , , cord-274141-vujx538o 63 9 Yang Yang NNP cord-274141-vujx538o 63 10 et et NNP cord-274141-vujx538o 63 11 al al NNP cord-274141-vujx538o 63 12 . . . cord-274141-vujx538o 64 1 ( ( -LRB- cord-274141-vujx538o 64 2 2020 2020 CD cord-274141-vujx538o 64 3 ) ) -RRB- cord-274141-vujx538o 64 4 reported report VBD cord-274141-vujx538o 64 5 that that IN cord-274141-vujx538o 64 6 more more JJR cord-274141-vujx538o 64 7 than than IN cord-274141-vujx538o 64 8 85 85 CD cord-274141-vujx538o 64 9 % % NN cord-274141-vujx538o 64 10 of of IN cord-274141-vujx538o 64 11 SARS SARS NNP cord-274141-vujx538o 64 12 - - HYPH cord-274141-vujx538o 64 13 CoV-2-infected cov-2-infecte VBN cord-274141-vujx538o 64 14 patients patient NNS cord-274141-vujx538o 64 15 in in IN cord-274141-vujx538o 64 16 China China NNP cord-274141-vujx538o 64 17 were be VBD cord-274141-vujx538o 64 18 treated treat VBN cord-274141-vujx538o 64 19 with with IN cord-274141-vujx538o 64 20 traditional traditional JJ cord-274141-vujx538o 64 21 Chinese chinese JJ cord-274141-vujx538o 64 22 medicine medicine NN cord-274141-vujx538o 64 23 ( ( -LRB- cord-274141-vujx538o 64 24 TCM TCM NNP cord-274141-vujx538o 64 25 ) ) -RRB- cord-274141-vujx538o 64 26 . . . cord-274141-vujx538o 65 1 During during IN cord-274141-vujx538o 65 2 the the DT cord-274141-vujx538o 65 3 2002 2002 CD cord-274141-vujx538o 65 4 to to IN cord-274141-vujx538o 65 5 2003 2003 CD cord-274141-vujx538o 65 6 outbreak outbreak NN cord-274141-vujx538o 65 7 , , , cord-274141-vujx538o 65 8 TCM TCM NNP cord-274141-vujx538o 65 9 was be VBD cord-274141-vujx538o 65 10 also also RB cord-274141-vujx538o 65 11 used use VBN cord-274141-vujx538o 65 12 as as IN cord-274141-vujx538o 65 13 a a DT cord-274141-vujx538o 65 14 supplementary supplementary JJ cord-274141-vujx538o 65 15 treatment treatment NN cord-274141-vujx538o 65 16 of of IN cord-274141-vujx538o 65 17 severe severe JJ cord-274141-vujx538o 65 18 laboratoryconfirmed laboratoryconfirmed JJ cord-274141-vujx538o 65 19 conditions condition NNS cord-274141-vujx538o 65 20 of of IN cord-274141-vujx538o 65 21 SARS SARS NNP cord-274141-vujx538o 65 22 ( ( -LRB- cord-274141-vujx538o 65 23 Hsu Hsu NNP cord-274141-vujx538o 65 24 et et FW cord-274141-vujx538o 65 25 al al NNP cord-274141-vujx538o 65 26 . . NNP cord-274141-vujx538o 65 27 2006a 2006a CD cord-274141-vujx538o 65 28 ) ) -RRB- cord-274141-vujx538o 65 29 . . . cord-274141-vujx538o 66 1 Along along IN cord-274141-vujx538o 66 2 this this DT cord-274141-vujx538o 66 3 trajectory trajectory NN cord-274141-vujx538o 66 4 , , , cord-274141-vujx538o 66 5 the the DT cord-274141-vujx538o 66 6 aim aim NN cord-274141-vujx538o 66 7 of of IN cord-274141-vujx538o 66 8 the the DT cord-274141-vujx538o 66 9 current current JJ cord-274141-vujx538o 66 10 review review NN cord-274141-vujx538o 66 11 is be VBZ cord-274141-vujx538o 66 12 to to TO cord-274141-vujx538o 66 13 provide provide VB cord-274141-vujx538o 66 14 an an DT cord-274141-vujx538o 66 15 update update NN cord-274141-vujx538o 66 16 on on IN cord-274141-vujx538o 66 17 the the DT cord-274141-vujx538o 66 18 bioactivity bioactivity NN cord-274141-vujx538o 66 19 functions function NNS cord-274141-vujx538o 66 20 of of IN cord-274141-vujx538o 66 21 medicinal medicinal JJ cord-274141-vujx538o 66 22 plants plant NNS cord-274141-vujx538o 66 23 and and CC cord-274141-vujx538o 66 24 other other JJ cord-274141-vujx538o 66 25 natural natural JJ cord-274141-vujx538o 66 26 products product NNS cord-274141-vujx538o 66 27 that that WDT cord-274141-vujx538o 66 28 have have VBP cord-274141-vujx538o 66 29 previously previously RB cord-274141-vujx538o 66 30 been be VBN cord-274141-vujx538o 66 31 used use VBN cord-274141-vujx538o 66 32 to to TO cord-274141-vujx538o 66 33 treat treat VB cord-274141-vujx538o 66 34 coronaviruses coronaviruse NNS cord-274141-vujx538o 66 35 . . . cord-274141-vujx538o 67 1 In in IN cord-274141-vujx538o 67 2 the the DT cord-274141-vujx538o 67 3 short short JJ cord-274141-vujx538o 67 4 term term NN cord-274141-vujx538o 67 5 , , , cord-274141-vujx538o 67 6 knowledge knowledge NN cord-274141-vujx538o 67 7 of of IN cord-274141-vujx538o 67 8 these these DT cord-274141-vujx538o 67 9 natural natural JJ cord-274141-vujx538o 67 10 products product NNS cord-274141-vujx538o 67 11 may may MD cord-274141-vujx538o 67 12 be be VB cord-274141-vujx538o 67 13 significant significant JJ cord-274141-vujx538o 67 14 in in IN cord-274141-vujx538o 67 15 the the DT cord-274141-vujx538o 67 16 relief relief NN cord-274141-vujx538o 67 17 of of IN cord-274141-vujx538o 67 18 COVID-19 covid-19 JJ cord-274141-vujx538o 67 19 symptoms symptom NNS cord-274141-vujx538o 67 20 . . . cord-274141-vujx538o 68 1 In in IN cord-274141-vujx538o 68 2 the the DT cord-274141-vujx538o 68 3 long long JJ cord-274141-vujx538o 68 4 term term NN cord-274141-vujx538o 68 5 , , , cord-274141-vujx538o 68 6 natural natural JJ cord-274141-vujx538o 68 7 products product NNS cord-274141-vujx538o 68 8 that that WDT cord-274141-vujx538o 68 9 alleviate alleviate VBP cord-274141-vujx538o 68 10 COVID-19 covid-19 CD cord-274141-vujx538o 68 11 symptoms symptom NNS cord-274141-vujx538o 68 12 may may MD cord-274141-vujx538o 68 13 be be VB cord-274141-vujx538o 68 14 used use VBN cord-274141-vujx538o 68 15 in in IN cord-274141-vujx538o 68 16 the the DT cord-274141-vujx538o 68 17 search search NN cord-274141-vujx538o 68 18 for for IN cord-274141-vujx538o 68 19 novel novel JJ cord-274141-vujx538o 68 20 drugs drug NNS cord-274141-vujx538o 68 21 against against IN cord-274141-vujx538o 68 22 SARS SARS NNP cord-274141-vujx538o 68 23 - - HYPH cord-274141-vujx538o 68 24 CoV-2 CoV-2 NNP cord-274141-vujx538o 68 25 . . . cord-274141-vujx538o 69 1 In in IN cord-274141-vujx538o 69 2 the the DT cord-274141-vujx538o 69 3 face face NN cord-274141-vujx538o 69 4 of of IN cord-274141-vujx538o 69 5 current current JJ cord-274141-vujx538o 69 6 challenges challenge NNS cord-274141-vujx538o 69 7 to to IN cord-274141-vujx538o 69 8 the the DT cord-274141-vujx538o 69 9 treatment treatment NN cord-274141-vujx538o 69 10 of of IN cord-274141-vujx538o 69 11 COVID-19 COVID-19 NNP cord-274141-vujx538o 69 12 , , , cord-274141-vujx538o 69 13 data datum NNS cord-274141-vujx538o 69 14 presented present VBN cord-274141-vujx538o 69 15 in in IN cord-274141-vujx538o 69 16 this this DT cord-274141-vujx538o 69 17 review review NN cord-274141-vujx538o 69 18 may may MD cord-274141-vujx538o 69 19 help help VB cord-274141-vujx538o 69 20 to to TO cord-274141-vujx538o 69 21 reimagine reimagine VB cord-274141-vujx538o 69 22 a a DT cord-274141-vujx538o 69 23 new new JJ cord-274141-vujx538o 69 24 future future NN cord-274141-vujx538o 69 25 where where WRB cord-274141-vujx538o 69 26 natural natural JJ cord-274141-vujx538o 69 27 products product NNS cord-274141-vujx538o 69 28 are be VBP cord-274141-vujx538o 69 29 the the DT cord-274141-vujx538o 69 30 new new JJ cord-274141-vujx538o 69 31 frontier frontier NN cord-274141-vujx538o 69 32 for for IN cord-274141-vujx538o 69 33 more more RBR cord-274141-vujx538o 69 34 efficacious efficacious JJ cord-274141-vujx538o 69 35 and and CC cord-274141-vujx538o 69 36 low low JJ cord-274141-vujx538o 69 37 - - HYPH cord-274141-vujx538o 69 38 cost cost NN cord-274141-vujx538o 69 39 SARS SARS NNP cord-274141-vujx538o 69 40 - - HYPH cord-274141-vujx538o 69 41 CoV-2 CoV-2 NNP cord-274141-vujx538o 69 42 inhibitors inhibitor NNS cord-274141-vujx538o 69 43 . . . cord-274141-vujx538o 70 1 The the DT cord-274141-vujx538o 70 2 goal goal NN cord-274141-vujx538o 70 3 is be VBZ cord-274141-vujx538o 70 4 to to TO cord-274141-vujx538o 70 5 create create VB cord-274141-vujx538o 70 6 a a DT cord-274141-vujx538o 70 7 strong strong JJ cord-274141-vujx538o 70 8 bioprospecting bioprospecting NN cord-274141-vujx538o 70 9 pipeline pipeline NN cord-274141-vujx538o 70 10 from from IN cord-274141-vujx538o 70 11 which which WDT cord-274141-vujx538o 70 12 pharmaceutical pharmaceutical JJ cord-274141-vujx538o 70 13 companies company NNS cord-274141-vujx538o 70 14 can can MD cord-274141-vujx538o 70 15 advance advance VB cord-274141-vujx538o 70 16 the the DT cord-274141-vujx538o 70 17 discovery discovery NN cord-274141-vujx538o 70 18 and and CC cord-274141-vujx538o 70 19 repurposing repurposing NN cord-274141-vujx538o 70 20 of of IN cord-274141-vujx538o 70 21 COVID-19 covid-19 JJ cord-274141-vujx538o 70 22 drugs drug NNS cord-274141-vujx538o 70 23 from from IN cord-274141-vujx538o 70 24 current current JJ cord-274141-vujx538o 70 25 medicinal medicinal JJ cord-274141-vujx538o 70 26 plants plant NNS cord-274141-vujx538o 70 27 and and CC cord-274141-vujx538o 70 28 other other JJ cord-274141-vujx538o 70 29 natural natural JJ cord-274141-vujx538o 70 30 products product NNS cord-274141-vujx538o 70 31 . . . cord-274141-vujx538o 71 1 To to TO cord-274141-vujx538o 71 2 prevent prevent VB cord-274141-vujx538o 71 3 author author NN cord-274141-vujx538o 71 4 bias bias NN cord-274141-vujx538o 71 5 , , , cord-274141-vujx538o 71 6 this this DT cord-274141-vujx538o 71 7 review review NN cord-274141-vujx538o 71 8 was be VBD cord-274141-vujx538o 71 9 carried carry VBN cord-274141-vujx538o 71 10 out out RP cord-274141-vujx538o 71 11 using use VBG cord-274141-vujx538o 71 12 a a DT cord-274141-vujx538o 71 13 comprehensive comprehensive JJ cord-274141-vujx538o 71 14 and and CC cord-274141-vujx538o 71 15 systematic systematic JJ cord-274141-vujx538o 71 16 data datum NNS cord-274141-vujx538o 71 17 mining mining NN cord-274141-vujx538o 71 18 approach approach NN cord-274141-vujx538o 71 19 similar similar JJ cord-274141-vujx538o 71 20 to to IN cord-274141-vujx538o 71 21 that that DT cord-274141-vujx538o 71 22 used use VBN cord-274141-vujx538o 71 23 by by IN cord-274141-vujx538o 71 24 Chinsembu Chinsembu NNP cord-274141-vujx538o 71 25 ( ( -LRB- cord-274141-vujx538o 71 26 2019 2019 CD cord-274141-vujx538o 71 27 ) ) -RRB- cord-274141-vujx538o 71 28 . . . cord-274141-vujx538o 72 1 To to TO cord-274141-vujx538o 72 2 obtain obtain VB cord-274141-vujx538o 72 3 pertinent pertinent JJ cord-274141-vujx538o 72 4 literature literature NN cord-274141-vujx538o 72 5 , , , cord-274141-vujx538o 72 6 the the DT cord-274141-vujx538o 72 7 key key JJ cord-274141-vujx538o 72 8 words word NNS cord-274141-vujx538o 72 9 " " `` cord-274141-vujx538o 72 10 SARS SARS NNP cord-274141-vujx538o 72 11 " " '' cord-274141-vujx538o 72 12 and and CC cord-274141-vujx538o 72 13 " " `` cord-274141-vujx538o 72 14 medicinal medicinal JJ cord-274141-vujx538o 72 15 plants plant NNS cord-274141-vujx538o 72 16 " " '' cord-274141-vujx538o 72 17 were be VBD cord-274141-vujx538o 72 18 concomitantly concomitantly RB cord-274141-vujx538o 72 19 searched search VBN cord-274141-vujx538o 72 20 in in IN cord-274141-vujx538o 72 21 Google Google NNP cord-274141-vujx538o 72 22 Scholar Scholar NNP cord-274141-vujx538o 72 23 , , , cord-274141-vujx538o 72 24 Elsevier Elsevier NNP cord-274141-vujx538o 72 25 's 's POS cord-274141-vujx538o 72 26 payto payto NN cord-274141-vujx538o 72 27 - - HYPH cord-274141-vujx538o 72 28 view view NN cord-274141-vujx538o 72 29 service service NN cord-274141-vujx538o 72 30 Science science NN cord-274141-vujx538o 72 31 Direct Direct NNP cord-274141-vujx538o 72 32 , , , cord-274141-vujx538o 72 33 Scopus Scopus NNP cord-274141-vujx538o 72 34 , , , cord-274141-vujx538o 72 35 Scielo Scielo NNP cord-274141-vujx538o 72 36 , , , cord-274141-vujx538o 72 37 and and CC cord-274141-vujx538o 72 38 PubMed PubMed NNP cord-274141-vujx538o 72 39 Central Central NNP cord-274141-vujx538o 72 40 , , , cord-274141-vujx538o 72 41 the the DT cord-274141-vujx538o 72 42 US US NNP cord-274141-vujx538o 72 43 National National NNP cord-274141-vujx538o 72 44 Library Library NNP cord-274141-vujx538o 72 45 of of IN cord-274141-vujx538o 72 46 Medicine Medicine NNP cord-274141-vujx538o 72 47 's 's POS cord-274141-vujx538o 72 48 digital digital JJ cord-274141-vujx538o 72 49 archive archive NN cord-274141-vujx538o 72 50 of of IN cord-274141-vujx538o 72 51 biomedical biomedical JJ cord-274141-vujx538o 72 52 and and CC cord-274141-vujx538o 72 53 life life NNP cord-274141-vujx538o 72 54 sciences sciences NNPS cord-274141-vujx538o 72 55 journal journal NNP cord-274141-vujx538o 72 56 literature literature NN cord-274141-vujx538o 72 57 . . . cord-274141-vujx538o 73 1 Literature literature NN cord-274141-vujx538o 73 2 sources source NNS cord-274141-vujx538o 73 3 included include VBD cord-274141-vujx538o 73 4 peer peer NN cord-274141-vujx538o 73 5 - - HYPH cord-274141-vujx538o 73 6 reviewed review VBN cord-274141-vujx538o 73 7 journal journal NN cord-274141-vujx538o 73 8 articles article NNS cord-274141-vujx538o 73 9 and and CC cord-274141-vujx538o 73 10 refereed refereed JJ cord-274141-vujx538o 73 11 books book NNS cord-274141-vujx538o 73 12 . . . cord-274141-vujx538o 74 1 Medicinal medicinal JJ cord-274141-vujx538o 74 2 plants plant NNS cord-274141-vujx538o 74 3 , , , cord-274141-vujx538o 74 4 mushrooms mushroom NNS cord-274141-vujx538o 74 5 , , , cord-274141-vujx538o 74 6 algae algae NN cord-274141-vujx538o 74 7 , , , cord-274141-vujx538o 74 8 and and CC cord-274141-vujx538o 74 9 sponges sponge NNS cord-274141-vujx538o 74 10 with with IN cord-274141-vujx538o 74 11 anti anti JJ cord-274141-vujx538o 74 12 - - JJ cord-274141-vujx538o 74 13 SARS SARS NNP cord-274141-vujx538o 74 14 activity activity NN cord-274141-vujx538o 74 15 were be VBD cord-274141-vujx538o 74 16 included include VBN cord-274141-vujx538o 74 17 . . . cord-274141-vujx538o 75 1 Wherever wherever WRB cord-274141-vujx538o 75 2 possible possible JJ cord-274141-vujx538o 75 3 , , , cord-274141-vujx538o 75 4 active active JJ cord-274141-vujx538o 75 5 compounds compound NNS cord-274141-vujx538o 75 6 and and CC cord-274141-vujx538o 75 7 anti anti JJ cord-274141-vujx538o 75 8 - - JJ cord-274141-vujx538o 75 9 SARS sars JJ cord-274141-vujx538o 75 10 profiles profile NNS cord-274141-vujx538o 76 1 mainly mainly RB cord-274141-vujx538o 76 2 half half DT cord-274141-vujx538o 76 3 maximal maximal JJ cord-274141-vujx538o 76 4 inhibitory inhibitory JJ cord-274141-vujx538o 76 5 concentration concentration NN cord-274141-vujx538o 76 6 ( ( -LRB- cord-274141-vujx538o 76 7 IC IC NNP cord-274141-vujx538o 76 8 50 50 CD cord-274141-vujx538o 76 9 ) ) -RRB- cord-274141-vujx538o 76 10 and and CC cord-274141-vujx538o 76 11 effective effective JJ cord-274141-vujx538o 76 12 concentration concentration NN cord-274141-vujx538o 76 13 ( ( -LRB- cord-274141-vujx538o 76 14 EC EC NNP cord-274141-vujx538o 76 15 50 50 CD cord-274141-vujx538o 76 16 ) ) -RRB- cord-274141-vujx538o 76 17 were be VBD cord-274141-vujx538o 76 18 recorded record VBN cord-274141-vujx538o 76 19 . . . cord-274141-vujx538o 77 1 Inclusion inclusion NN cord-274141-vujx538o 77 2 criteria criterion NNS cord-274141-vujx538o 77 3 included include VBD cord-274141-vujx538o 77 4 plants plant NNS cord-274141-vujx538o 77 5 , , , cord-274141-vujx538o 77 6 fungi fungus NNS cord-274141-vujx538o 77 7 , , , cord-274141-vujx538o 77 8 and and CC cord-274141-vujx538o 77 9 marine marine JJ cord-274141-vujx538o 77 10 organisms organism NNS cord-274141-vujx538o 77 11 , , , cord-274141-vujx538o 77 12 namely namely RB cord-274141-vujx538o 77 13 algae algae NN cord-274141-vujx538o 77 14 and and CC cord-274141-vujx538o 77 15 sponges sponge NNS cord-274141-vujx538o 77 16 . . . cord-274141-vujx538o 78 1 Exclusion exclusion NN cord-274141-vujx538o 78 2 criteria criterion NNS cord-274141-vujx538o 78 3 included include VBD cord-274141-vujx538o 78 4 animal animal NN cord-274141-vujx538o 78 5 products product NNS cord-274141-vujx538o 78 6 . . . cord-274141-vujx538o 79 1 Countries country NNS cord-274141-vujx538o 79 2 reported report VBN cord-274141-vujx538o 79 3 in in IN cord-274141-vujx538o 79 4 the the DT cord-274141-vujx538o 79 5 review review NN cord-274141-vujx538o 79 6 were be VBD cord-274141-vujx538o 79 7 those those DT cord-274141-vujx538o 79 8 where where WRB cord-274141-vujx538o 79 9 primary primary JJ cord-274141-vujx538o 79 10 data datum NNS cord-274141-vujx538o 79 11 were be VBD cord-274141-vujx538o 79 12 collected collect VBN cord-274141-vujx538o 79 13 ; ; : cord-274141-vujx538o 79 14 hence hence RB cord-274141-vujx538o 79 15 , , , cord-274141-vujx538o 79 16 geographical geographical JJ cord-274141-vujx538o 79 17 scope scope NN cord-274141-vujx538o 79 18 was be VBD cord-274141-vujx538o 79 19 not not RB cord-274141-vujx538o 79 20 deliberately deliberately RB cord-274141-vujx538o 79 21 selected select VBN cord-274141-vujx538o 79 22 . . . cord-274141-vujx538o 80 1 The the DT cord-274141-vujx538o 80 2 International International NNP cord-274141-vujx538o 80 3 Plant Plant NNP cord-274141-vujx538o 80 4 Names Names NNPS cord-274141-vujx538o 80 5 Index Index NNP cord-274141-vujx538o 80 6 ( ( -LRB- cord-274141-vujx538o 80 7 http://www.ipni.org http://www.ipni.org NFP cord-274141-vujx538o 80 8 ) ) -RRB- cord-274141-vujx538o 80 9 and and CC cord-274141-vujx538o 80 10 The the DT cord-274141-vujx538o 80 11 Plant Plant NNP cord-274141-vujx538o 80 12 List List NNP cord-274141-vujx538o 80 13 ( ( -LRB- cord-274141-vujx538o 80 14 http://www.theplantlist.org http://www.theplantlist.org NN cord-274141-vujx538o 80 15 ) ) -RRB- cord-274141-vujx538o 80 16 were be VBD cord-274141-vujx538o 80 17 used use VBN cord-274141-vujx538o 80 18 to to TO cord-274141-vujx538o 80 19 verify verify VB cord-274141-vujx538o 80 20 names name NNS cord-274141-vujx538o 80 21 of of IN cord-274141-vujx538o 80 22 plant plant NN cord-274141-vujx538o 80 23 species specie NNS cord-274141-vujx538o 80 24 . . . cord-274141-vujx538o 81 1 The the DT cord-274141-vujx538o 81 2 spike spike NN cord-274141-vujx538o 81 3 protein protein NN cord-274141-vujx538o 81 4 , , , cord-274141-vujx538o 81 5 a a DT cord-274141-vujx538o 81 6 type type NN cord-274141-vujx538o 81 7 I -PRON- PRP cord-274141-vujx538o 81 8 membrane membrane NN cord-274141-vujx538o 81 9 - - HYPH cord-274141-vujx538o 81 10 bound bind VBN cord-274141-vujx538o 81 11 protein protein NN cord-274141-vujx538o 81 12 , , , cord-274141-vujx538o 81 13 is be VBZ cord-274141-vujx538o 81 14 essential essential JJ cord-274141-vujx538o 81 15 for for IN cord-274141-vujx538o 81 16 SARS SARS NNP cord-274141-vujx538o 81 17 - - HYPH cord-274141-vujx538o 81 18 CoV CoV NNP cord-274141-vujx538o 81 19 attachment attachment NN cord-274141-vujx538o 81 20 to to IN cord-274141-vujx538o 81 21 the the DT cord-274141-vujx538o 81 22 host host NN cord-274141-vujx538o 81 23 cell cell NN cord-274141-vujx538o 81 24 receptor receptor NN cord-274141-vujx538o 81 25 angiotensin angiotensin NN cord-274141-vujx538o 81 26 - - HYPH cord-274141-vujx538o 81 27 converting convert VBG cord-274141-vujx538o 81 28 enzyme enzyme NN cord-274141-vujx538o 81 29 2 2 CD cord-274141-vujx538o 81 30 ( ( -LRB- cord-274141-vujx538o 81 31 ACE2 ACE2 NNP cord-274141-vujx538o 81 32 ) ) -RRB- cord-274141-vujx538o 81 33 . . . cord-274141-vujx538o 82 1 In in IN cord-274141-vujx538o 82 2 general general JJ cord-274141-vujx538o 82 3 , , , cord-274141-vujx538o 82 4 SARS SARS NNP cord-274141-vujx538o 82 5 - - HYPH cord-274141-vujx538o 82 6 CoV CoV NNP cord-274141-vujx538o 82 7 entry entry NN cord-274141-vujx538o 82 8 starts start VBZ cord-274141-vujx538o 82 9 with with IN cord-274141-vujx538o 82 10 the the DT cord-274141-vujx538o 82 11 attachment attachment NN cord-274141-vujx538o 82 12 of of IN cord-274141-vujx538o 82 13 the the DT cord-274141-vujx538o 82 14 virus virus NN cord-274141-vujx538o 82 15 to to IN cord-274141-vujx538o 82 16 its -PRON- PRP$ cord-274141-vujx538o 82 17 specific specific JJ cord-274141-vujx538o 82 18 receptor receptor NN cord-274141-vujx538o 82 19 ACE2 ACE2 NNP cord-274141-vujx538o 82 20 on on IN cord-274141-vujx538o 82 21 the the DT cord-274141-vujx538o 82 22 host host NN cord-274141-vujx538o 82 23 cell cell NN cord-274141-vujx538o 82 24 surface surface NN cord-274141-vujx538o 82 25 ( ( -LRB- cord-274141-vujx538o 82 26 Keyaerts Keyaerts NNP cord-274141-vujx538o 82 27 et et NNP cord-274141-vujx538o 82 28 al al NNP cord-274141-vujx538o 82 29 . . NNP cord-274141-vujx538o 82 30 2007 2007 CD cord-274141-vujx538o 82 31 ) ) -RRB- cord-274141-vujx538o 82 32 . . . cord-274141-vujx538o 83 1 Binding Binding NNP cord-274141-vujx538o 83 2 of of IN cord-274141-vujx538o 83 3 ACE2 ACE2 NNP cord-274141-vujx538o 83 4 then then RB cord-274141-vujx538o 83 5 induces induce VBZ cord-274141-vujx538o 83 6 the the DT cord-274141-vujx538o 83 7 viral viral JJ cord-274141-vujx538o 83 8 envelope envelope NN cord-274141-vujx538o 83 9 protein protein NN cord-274141-vujx538o 83 10 to to TO cord-274141-vujx538o 83 11 undergo undergo VB cord-274141-vujx538o 83 12 conformational conformational JJ cord-274141-vujx538o 83 13 changes change NNS cord-274141-vujx538o 83 14 that that WDT cord-274141-vujx538o 83 15 mediate mediate VBP cord-274141-vujx538o 83 16 fusion fusion NN cord-274141-vujx538o 83 17 between between IN cord-274141-vujx538o 83 18 SARS SARS NNP cord-274141-vujx538o 83 19 - - HYPH cord-274141-vujx538o 83 20 CoV CoV NNP cord-274141-vujx538o 83 21 and and CC cord-274141-vujx538o 83 22 host host NN cord-274141-vujx538o 83 23 cell cell NN cord-274141-vujx538o 83 24 membranes membrane NNS cord-274141-vujx538o 83 25 . . . cord-274141-vujx538o 84 1 The the DT cord-274141-vujx538o 84 2 spike spike NN cord-274141-vujx538o 84 3 protein protein NN cord-274141-vujx538o 84 4 is be VBZ cord-274141-vujx538o 84 5 responsible responsible JJ cord-274141-vujx538o 84 6 for for IN cord-274141-vujx538o 84 7 these these DT cord-274141-vujx538o 84 8 two two CD cord-274141-vujx538o 84 9 steps step NNS cord-274141-vujx538o 84 10 in in IN cord-274141-vujx538o 84 11 the the DT cord-274141-vujx538o 84 12 coronavirus coronavirus NN cord-274141-vujx538o 84 13 entry entry NN cord-274141-vujx538o 84 14 process process NN cord-274141-vujx538o 84 15 ( ( -LRB- cord-274141-vujx538o 84 16 Keyaerts Keyaerts NNP cord-274141-vujx538o 84 17 et et NNP cord-274141-vujx538o 84 18 al al NNP cord-274141-vujx538o 84 19 . . NNP cord-274141-vujx538o 84 20 2007 2007 CD cord-274141-vujx538o 84 21 ) ) -RRB- cord-274141-vujx538o 84 22 . . . cord-274141-vujx538o 85 1 A a DT cord-274141-vujx538o 85 2 member member NN cord-274141-vujx538o 85 3 of of IN cord-274141-vujx538o 85 4 the the DT cord-274141-vujx538o 85 5 C C NNP cord-274141-vujx538o 85 6 - - HYPH cord-274141-vujx538o 85 7 type type NN cord-274141-vujx538o 85 8 lectin lectin NN cord-274141-vujx538o 85 9 superfamily superfamily NN cord-274141-vujx538o 85 10 , , , cord-274141-vujx538o 85 11 dendritic dendritic JJ cord-274141-vujx538o 85 12 cell cell NN cord-274141-vujx538o 85 13 ( ( -LRB- cord-274141-vujx538o 85 14 DC)-specific dc)-specific CD cord-274141-vujx538o 85 15 ICAMgrabbing icamgrabbe VBG cord-274141-vujx538o 85 16 non non JJ cord-274141-vujx538o 85 17 - - JJ cord-274141-vujx538o 85 18 intergrin intergrin JJ cord-274141-vujx538o 85 19 ( ( -LRB- cord-274141-vujx538o 85 20 DC DC NNP cord-274141-vujx538o 85 21 - - HYPH cord-274141-vujx538o 85 22 SIGN SIGN NNP cord-274141-vujx538o 85 23 ) ) -RRB- cord-274141-vujx538o 85 24 , , , cord-274141-vujx538o 85 25 a a DT cord-274141-vujx538o 85 26 molecule molecule NN cord-274141-vujx538o 85 27 designated designate VBN cord-274141-vujx538o 85 28 as as IN cord-274141-vujx538o 85 29 CD209 cd209 NN cord-274141-vujx538o 85 30 , , , cord-274141-vujx538o 85 31 binds bind VBZ cord-274141-vujx538o 85 32 to to IN cord-274141-vujx538o 85 33 surface surface NN cord-274141-vujx538o 85 34 proteins protein NNS cord-274141-vujx538o 85 35 of of IN cord-274141-vujx538o 85 36 SARS SARS NNP cord-274141-vujx538o 85 37 - - HYPH cord-274141-vujx538o 85 38 CoV CoV NNP cord-274141-vujx538o 85 39 , , , cord-274141-vujx538o 85 40 consequently consequently RB cord-274141-vujx538o 85 41 facilitating facilitate VBG cord-274141-vujx538o 85 42 viral viral JJ cord-274141-vujx538o 85 43 entry entry NN cord-274141-vujx538o 86 1 ( ( -LRB- cord-274141-vujx538o 86 2 Liu Liu NNP cord-274141-vujx538o 86 3 et et NNP cord-274141-vujx538o 86 4 al al NNP cord-274141-vujx538o 86 5 . . NNP cord-274141-vujx538o 86 6 2015 2015 CD cord-274141-vujx538o 86 7 ) ) -RRB- cord-274141-vujx538o 86 8 . . . cord-274141-vujx538o 87 1 SARS SARS NNP cord-274141-vujx538o 87 2 - - HYPH cord-274141-vujx538o 87 3 CoV CoV NNP cord-274141-vujx538o 87 4 spike spike NN cord-274141-vujx538o 87 5 protein protein NN cord-274141-vujx538o 87 6 contains contain VBZ cord-274141-vujx538o 87 7 a a DT cord-274141-vujx538o 87 8 number number NN cord-274141-vujx538o 87 9 of of IN cord-274141-vujx538o 87 10 N n CD cord-274141-vujx538o 87 11 - - HYPH cord-274141-vujx538o 87 12 linked link VBN cord-274141-vujx538o 87 13 glycosylation glycosylation NN cord-274141-vujx538o 87 14 sites site NNS cord-274141-vujx538o 87 15 that that WDT cord-274141-vujx538o 87 16 modulate modulate VBP cord-274141-vujx538o 87 17 binding bind VBG cord-274141-vujx538o 87 18 to to IN cord-274141-vujx538o 87 19 the the DT cord-274141-vujx538o 87 20 DC DC NNP cord-274141-vujx538o 87 21 - - HYPH cord-274141-vujx538o 87 22 SIGN sign NN cord-274141-vujx538o 87 23 receptor receptor NN cord-274141-vujx538o 87 24 on on IN cord-274141-vujx538o 87 25 DC DC NNP cord-274141-vujx538o 87 26 ( ( -LRB- cord-274141-vujx538o 87 27 Zhang Zhang NNP cord-274141-vujx538o 87 28 et et NNP cord-274141-vujx538o 87 29 al al NNP cord-274141-vujx538o 87 30 . . NNP cord-274141-vujx538o 87 31 2007 2007 CD cord-274141-vujx538o 87 32 ) ) -RRB- cord-274141-vujx538o 87 33 . . . cord-274141-vujx538o 88 1 SARS SARS NNP cord-274141-vujx538o 88 2 - - HYPH cord-274141-vujx538o 88 3 CoV CoV NNP cord-274141-vujx538o 88 4 binding binding NN cord-274141-vujx538o 88 5 to to IN cord-274141-vujx538o 88 6 DC DC NNP cord-274141-vujx538o 88 7 - - HYPH cord-274141-vujx538o 88 8 SIGN SIGN NNP cord-274141-vujx538o 88 9 is be VBZ cord-274141-vujx538o 88 10 required require VBN cord-274141-vujx538o 88 11 for for IN cord-274141-vujx538o 88 12 DC DC NNP cord-274141-vujx538o 88 13 infection infection NN cord-274141-vujx538o 88 14 and and CC cord-274141-vujx538o 88 15 target target NN cord-274141-vujx538o 88 16 cell cell NN cord-274141-vujx538o 88 17 trans trans NN cord-274141-vujx538o 88 18 - - NN cord-274141-vujx538o 88 19 infection infection NN cord-274141-vujx538o 88 20 . . . cord-274141-vujx538o 89 1 DC DC NNP cord-274141-vujx538o 89 2 - - HYPH cord-274141-vujx538o 89 3 SIGN SIGN NNP cord-274141-vujx538o 89 4 plays play VBZ cord-274141-vujx538o 89 5 an an DT cord-274141-vujx538o 89 6 important important JJ cord-274141-vujx538o 89 7 role role NN cord-274141-vujx538o 89 8 in in IN cord-274141-vujx538o 89 9 mediating mediate VBG cord-274141-vujx538o 89 10 DC DC NNP cord-274141-vujx538o 89 11 adhesion adhesion NN cord-274141-vujx538o 89 12 and and CC cord-274141-vujx538o 89 13 internalization internalization NN cord-274141-vujx538o 89 14 of of IN cord-274141-vujx538o 89 15 SARS SARS NNP cord-274141-vujx538o 89 16 - - HYPH cord-274141-vujx538o 89 17 CoV. CoV. NNP cord-274141-vujx538o 89 18 Antiviral antiviral JJ cord-274141-vujx538o 89 19 agents agent NNS cord-274141-vujx538o 89 20 from from IN cord-274141-vujx538o 89 21 plants plant NNS cord-274141-vujx538o 89 22 generally generally RB cord-274141-vujx538o 89 23 block block VBP cord-274141-vujx538o 89 24 virus virus NN cord-274141-vujx538o 89 25 entry entry NN cord-274141-vujx538o 89 26 and and CC cord-274141-vujx538o 89 27 membrane membrane NN cord-274141-vujx538o 89 28 fusion fusion NN cord-274141-vujx538o 90 1 ( ( -LRB- cord-274141-vujx538o 90 2 Hsieh Hsieh NNP cord-274141-vujx538o 90 3 et et NNP cord-274141-vujx538o 90 4 al al NNP cord-274141-vujx538o 90 5 . . . cord-274141-vujx538o 90 6 2004 2004 CD cord-274141-vujx538o 90 7 ) ) -RRB- cord-274141-vujx538o 90 8 . . . cord-274141-vujx538o 91 1 De De NNP cord-274141-vujx538o 91 2 Clercq Clercq NNP cord-274141-vujx538o 91 3 ( ( -LRB- cord-274141-vujx538o 91 4 2005 2005 CD cord-274141-vujx538o 91 5 suggested suggest VBD cord-274141-vujx538o 91 6 that that IN cord-274141-vujx538o 91 7 it -PRON- PRP cord-274141-vujx538o 91 8 was be VBD cord-274141-vujx538o 91 9 feasible feasible JJ cord-274141-vujx538o 91 10 to to TO cord-274141-vujx538o 91 11 develop develop VB cord-274141-vujx538o 91 12 SARS SARS NNP cord-274141-vujx538o 91 13 - - HYPH cord-274141-vujx538o 91 14 CoV CoV NNP cord-274141-vujx538o 91 15 fusion fusion NN cord-274141-vujx538o 91 16 inhibitors inhibitor NNS cord-274141-vujx538o 91 17 analogous analogous JJ cord-274141-vujx538o 91 18 to to IN cord-274141-vujx538o 91 19 enfuvirtide enfuvirtide NNP cord-274141-vujx538o 91 20 , , , cord-274141-vujx538o 91 21 a a DT cord-274141-vujx538o 91 22 linear linear JJ cord-274141-vujx538o 91 23 36-amino 36-amino CD cord-274141-vujx538o 91 24 acid acid NN cord-274141-vujx538o 91 25 synthetic synthetic JJ cord-274141-vujx538o 91 26 peptide peptide NN cord-274141-vujx538o 91 27 marketed market VBN cord-274141-vujx538o 91 28 under under IN cord-274141-vujx538o 91 29 the the DT cord-274141-vujx538o 91 30 trade trade NN cord-274141-vujx538o 91 31 name name NN cord-274141-vujx538o 91 32 Fuzeon Fuzeon NNP cord-274141-vujx538o 91 33 , , , cord-274141-vujx538o 91 34 an an DT cord-274141-vujx538o 91 35 approved approve VBN cord-274141-vujx538o 91 36 anti anti JJ cord-274141-vujx538o 91 37 - - JJ cord-274141-vujx538o 91 38 HIV hiv JJ cord-274141-vujx538o 91 39 drug drug NN cord-274141-vujx538o 91 40 that that WDT cord-274141-vujx538o 91 41 inhibits inhibit VBZ cord-274141-vujx538o 91 42 the the DT cord-274141-vujx538o 91 43 entry entry NN cord-274141-vujx538o 91 44 of of IN cord-274141-vujx538o 91 45 the the DT cord-274141-vujx538o 91 46 virus virus NN cord-274141-vujx538o 91 47 into into IN cord-274141-vujx538o 91 48 cells cell NNS cord-274141-vujx538o 91 49 . . . cord-274141-vujx538o 92 1 SARS SARS NNP cord-274141-vujx538o 92 2 - - HYPH cord-274141-vujx538o 92 3 CoV CoV NNP cord-274141-vujx538o 92 4 entry entry NN cord-274141-vujx538o 92 5 inhibitors inhibitor NNS cord-274141-vujx538o 92 6 fall fall VBP cord-274141-vujx538o 92 7 into into IN cord-274141-vujx538o 92 8 several several JJ cord-274141-vujx538o 92 9 categories category NNS cord-274141-vujx538o 92 10 . . . cord-274141-vujx538o 93 1 The the DT cord-274141-vujx538o 93 2 first first JJ cord-274141-vujx538o 93 3 group group NN cord-274141-vujx538o 93 4 consists consist VBZ cord-274141-vujx538o 93 5 of of IN cord-274141-vujx538o 93 6 inhibitors inhibitor NNS cord-274141-vujx538o 93 7 that that WDT cord-274141-vujx538o 93 8 bind bind VBP cord-274141-vujx538o 93 9 to to IN cord-274141-vujx538o 93 10 the the DT cord-274141-vujx538o 93 11 ACE2 ACE2 NNP cord-274141-vujx538o 93 12 receptor receptor NN cord-274141-vujx538o 93 13 , , , cord-274141-vujx538o 93 14 the the DT cord-274141-vujx538o 93 15 second second JJ cord-274141-vujx538o 93 16 class class NN cord-274141-vujx538o 93 17 comprises comprise VBZ cord-274141-vujx538o 93 18 entry entry NN cord-274141-vujx538o 93 19 inhibitors inhibitor NNS cord-274141-vujx538o 93 20 that that WDT cord-274141-vujx538o 93 21 bind bind VBP cord-274141-vujx538o 93 22 to to IN cord-274141-vujx538o 93 23 the the DT cord-274141-vujx538o 93 24 virus virus NN cord-274141-vujx538o 93 25 and and CC cord-274141-vujx538o 93 26 prevent prevent VB cord-274141-vujx538o 93 27 it -PRON- PRP cord-274141-vujx538o 93 28 from from IN cord-274141-vujx538o 93 29 interacting interact VBG cord-274141-vujx538o 93 30 with with IN cord-274141-vujx538o 93 31 its -PRON- PRP$ cord-274141-vujx538o 93 32 receptors receptor NNS cord-274141-vujx538o 93 33 , , , cord-274141-vujx538o 93 34 and and CC cord-274141-vujx538o 93 35 the the DT cord-274141-vujx538o 93 36 third third JJ cord-274141-vujx538o 93 37 set set NN cord-274141-vujx538o 93 38 of of IN cord-274141-vujx538o 93 39 inhibitors inhibitor NNS cord-274141-vujx538o 93 40 can can MD cord-274141-vujx538o 93 41 obstruct obstruct VB cord-274141-vujx538o 93 42 the the DT cord-274141-vujx538o 93 43 conformational conformational JJ cord-274141-vujx538o 93 44 changes change NNS cord-274141-vujx538o 93 45 thus thus RB cord-274141-vujx538o 93 46 thwarting thwart VBG cord-274141-vujx538o 93 47 SARS SARS NNP cord-274141-vujx538o 93 48 - - HYPH cord-274141-vujx538o 93 49 CoV CoV NNP cord-274141-vujx538o 93 50 fusion fusion NN cord-274141-vujx538o 93 51 with with IN cord-274141-vujx538o 93 52 the the DT cord-274141-vujx538o 93 53 target target NN cord-274141-vujx538o 93 54 cells cell NNS cord-274141-vujx538o 93 55 ( ( -LRB- cord-274141-vujx538o 93 56 Keyaerts Keyaerts NNP cord-274141-vujx538o 93 57 et et NNP cord-274141-vujx538o 93 58 al al NNP cord-274141-vujx538o 93 59 . . NNP cord-274141-vujx538o 93 60 2007 2007 CD cord-274141-vujx538o 93 61 ) ) -RRB- cord-274141-vujx538o 93 62 . . . cord-274141-vujx538o 94 1 An an DT cord-274141-vujx538o 94 2 effective effective JJ cord-274141-vujx538o 94 3 inhibitor inhibitor NN cord-274141-vujx538o 94 4 of of IN cord-274141-vujx538o 94 5 SARS SARS NNP cord-274141-vujx538o 94 6 - - HYPH cord-274141-vujx538o 94 7 CoV CoV NNP cord-274141-vujx538o 94 8 , , , cord-274141-vujx538o 94 9 the the DT cord-274141-vujx538o 94 10 medicinal medicinal JJ cord-274141-vujx538o 94 11 basidiomycete basidiomycete JJ cord-274141-vujx538o 94 12 Ganoderma Ganoderma NNP cord-274141-vujx538o 94 13 lucidum lucidum NN cord-274141-vujx538o 94 14 ( ( -LRB- cord-274141-vujx538o 94 15 Curtis Curtis NNP cord-274141-vujx538o 94 16 ) ) -RRB- cord-274141-vujx538o 94 17 Karst Karst NNP cord-274141-vujx538o 94 18 . . . cord-274141-vujx538o 95 1 contains contain VBZ cord-274141-vujx538o 95 2 ganoderic ganoderic JJ cord-274141-vujx538o 95 3 acid acid NNP cord-274141-vujx538o 95 4 F F NNP cord-274141-vujx538o 95 5 , , , cord-274141-vujx538o 95 6 a a DT cord-274141-vujx538o 95 7 lanostane lanostane JJR cord-274141-vujx538o 95 8 triterpene triterpene NNP cord-274141-vujx538o 95 9 that that WDT cord-274141-vujx538o 95 10 acts act VBZ cord-274141-vujx538o 95 11 as as IN cord-274141-vujx538o 95 12 an an DT cord-274141-vujx538o 95 13 inhibitor inhibitor NN cord-274141-vujx538o 95 14 of of IN cord-274141-vujx538o 95 15 ACE2 ACE2 NNP cord-274141-vujx538o 95 16 receptor receptor NN cord-274141-vujx538o 95 17 ( ( -LRB- cord-274141-vujx538o 95 18 IC IC NNP cord-274141-vujx538o 95 19 50 50 CD cord-274141-vujx538o 95 20 4.7 4.7 CD cord-274141-vujx538o 95 21 × × CD cord-274141-vujx538o 95 22 10 10 CD cord-274141-vujx538o 95 23 −6 −6 NNP cord-274141-vujx538o 95 24 M M NNP cord-274141-vujx538o 95 25 ) ) -RRB- cord-274141-vujx538o 96 1 ( ( -LRB- cord-274141-vujx538o 96 2 Morigiwa Morigiwa NNP cord-274141-vujx538o 96 3 et et NNP cord-274141-vujx538o 96 4 al al NNP cord-274141-vujx538o 96 5 . . NNP cord-274141-vujx538o 96 6 1986 1986 CD cord-274141-vujx538o 96 7 ) ) -RRB- cord-274141-vujx538o 96 8 . . . cord-274141-vujx538o 97 1 Lee Lee NNP cord-274141-vujx538o 97 2 ( ( -LRB- cord-274141-vujx538o 97 3 2019 2019 CD cord-274141-vujx538o 97 4 ) ) -RRB- cord-274141-vujx538o 97 5 asserts assert VBZ cord-274141-vujx538o 97 6 that that IN cord-274141-vujx538o 97 7 lectins lectin NNS cord-274141-vujx538o 97 8 have have VBP cord-274141-vujx538o 97 9 emerged emerge VBN cord-274141-vujx538o 97 10 as as IN cord-274141-vujx538o 97 11 a a DT cord-274141-vujx538o 97 12 new new JJ cord-274141-vujx538o 97 13 class class NN cord-274141-vujx538o 97 14 of of IN cord-274141-vujx538o 97 15 antiviral antiviral JJ cord-274141-vujx538o 97 16 biologic biologic JJ cord-274141-vujx538o 97 17 drugs drug NNS cord-274141-vujx538o 97 18 or or CC cord-274141-vujx538o 97 19 biologics biologic NNS cord-274141-vujx538o 97 20 by by IN cord-274141-vujx538o 97 21 taking take VBG cord-274141-vujx538o 97 22 advantage advantage NN cord-274141-vujx538o 97 23 of of IN cord-274141-vujx538o 97 24 a a DT cord-274141-vujx538o 97 25 unique unique JJ cord-274141-vujx538o 97 26 glycosylation glycosylation NN cord-274141-vujx538o 97 27 pattern pattern NN cord-274141-vujx538o 97 28 only only RB cord-274141-vujx538o 97 29 found find VBD cord-274141-vujx538o 97 30 on on IN cord-274141-vujx538o 97 31 the the DT cord-274141-vujx538o 97 32 surface surface NN cord-274141-vujx538o 97 33 of of IN cord-274141-vujx538o 97 34 viruses virus NNS cord-274141-vujx538o 97 35 . . . cord-274141-vujx538o 98 1 Lectins Lectins NNP cord-274141-vujx538o 98 2 , , , cord-274141-vujx538o 98 3 a a DT cord-274141-vujx538o 98 4 group group NN cord-274141-vujx538o 98 5 of of IN cord-274141-vujx538o 98 6 proteins protein NNS cord-274141-vujx538o 98 7 with with IN cord-274141-vujx538o 98 8 carbohydrate carbohydrate NN cord-274141-vujx538o 98 9 recognition recognition NN cord-274141-vujx538o 98 10 activity activity NN cord-274141-vujx538o 98 11 , , , cord-274141-vujx538o 98 12 recognize recognize VB cord-274141-vujx538o 98 13 the the DT cord-274141-vujx538o 98 14 SARS SARS NNP cord-274141-vujx538o 98 15 - - HYPH cord-274141-vujx538o 98 16 CoV CoV NNP cord-274141-vujx538o 98 17 spike spike NN cord-274141-vujx538o 98 18 protein protein NN cord-274141-vujx538o 98 19 ( ( -LRB- cord-274141-vujx538o 98 20 Liu Liu NNP cord-274141-vujx538o 98 21 et et NNP cord-274141-vujx538o 98 22 al al NNP cord-274141-vujx538o 98 23 . . NNP cord-274141-vujx538o 98 24 2015 2015 CD cord-274141-vujx538o 98 25 ) ) -RRB- cord-274141-vujx538o 98 26 . . . cord-274141-vujx538o 99 1 Keyaerts Keyaerts NNP cord-274141-vujx538o 99 2 et et NNP cord-274141-vujx538o 99 3 al al NNP cord-274141-vujx538o 99 4 . . . cord-274141-vujx538o 100 1 ( ( -LRB- cord-274141-vujx538o 100 2 2007 2007 CD cord-274141-vujx538o 100 3 ) ) -RRB- cord-274141-vujx538o 100 4 found find VBD cord-274141-vujx538o 100 5 prominent prominent JJ cord-274141-vujx538o 100 6 anti anti JJ cord-274141-vujx538o 100 7 - - JJ cord-274141-vujx538o 100 8 SARS SARS NNP cord-274141-vujx538o 100 9 - - HYPH cord-274141-vujx538o 100 10 CoV cov NN cord-274141-vujx538o 100 11 activity activity NN cord-274141-vujx538o 100 12 among among IN cord-274141-vujx538o 100 13 mannose mannose NN cord-274141-vujx538o 100 14 - - HYPH cord-274141-vujx538o 100 15 specific specific JJ cord-274141-vujx538o 100 16 plant plant NN cord-274141-vujx538o 100 17 lectins lectin NNS cord-274141-vujx538o 100 18 . . . cord-274141-vujx538o 101 1 One one CD cord-274141-vujx538o 101 2 of of IN cord-274141-vujx538o 101 3 the the DT cord-274141-vujx538o 101 4 most most RBS cord-274141-vujx538o 101 5 potent potent JJ cord-274141-vujx538o 101 6 lectins lectin NNS cord-274141-vujx538o 101 7 against against IN cord-274141-vujx538o 101 8 the the DT cord-274141-vujx538o 101 9 SARS SARS NNP cord-274141-vujx538o 101 10 - - HYPH cord-274141-vujx538o 101 11 CoVinduced CoVinduced NNP cord-274141-vujx538o 101 12 cytopathicity cytopathicity NN cord-274141-vujx538o 101 13 is be VBZ cord-274141-vujx538o 101 14 the the DT cord-274141-vujx538o 101 15 mannose mannose NN cord-274141-vujx538o 101 16 - - HYPH cord-274141-vujx538o 101 17 specific specific JJ cord-274141-vujx538o 101 18 plant plant NN cord-274141-vujx538o 101 19 lectin lectin NN cord-274141-vujx538o 101 20 isolated isolate VBN cord-274141-vujx538o 101 21 from from IN cord-274141-vujx538o 101 22 leek leek NNP cord-274141-vujx538o 101 23 ( ( -LRB- cord-274141-vujx538o 101 24 Allium Allium NNP cord-274141-vujx538o 101 25 porrum porrum NNP cord-274141-vujx538o 101 26 L. L. NNP cord-274141-vujx538o 101 27 ) ) -RRB- cord-274141-vujx538o 101 28 with with IN cord-274141-vujx538o 101 29 an an DT cord-274141-vujx538o 101 30 EC EC NNP cord-274141-vujx538o 101 31 50 50 CD cord-274141-vujx538o 101 32 of of IN cord-274141-vujx538o 101 33 0.45 0.45 CD cord-274141-vujx538o 101 34 μg μg NNP cord-274141-vujx538o 101 35 / / SYM cord-274141-vujx538o 101 36 ml ml NN cord-274141-vujx538o 101 37 and and CC cord-274141-vujx538o 101 38 a a DT cord-274141-vujx538o 101 39 selectivity selectivity NN cord-274141-vujx538o 101 40 index index NN cord-274141-vujx538o 101 41 of of IN cord-274141-vujx538o 101 42 > > $ cord-274141-vujx538o 101 43 222 222 CD cord-274141-vujx538o 101 44 . . . cord-274141-vujx538o 102 1 The the DT cord-274141-vujx538o 102 2 N N NNP cord-274141-vujx538o 102 3 - - HYPH cord-274141-vujx538o 102 4 acetyl acetyl NN cord-274141-vujx538o 102 5 glucosamine glucosamine NN cord-274141-vujx538o 102 6 - - HYPH cord-274141-vujx538o 102 7 specific specific JJ cord-274141-vujx538o 102 8 lectins lectin NNS cord-274141-vujx538o 102 9 isolated isolate VBN cord-274141-vujx538o 102 10 from from IN cord-274141-vujx538o 102 11 the the DT cord-274141-vujx538o 102 12 stinging stinging JJ cord-274141-vujx538o 102 13 nettle nettle NN cord-274141-vujx538o 102 14 ( ( -LRB- cord-274141-vujx538o 102 15 Urtica Urtica NNP cord-274141-vujx538o 102 16 dioica dioica NNP cord-274141-vujx538o 102 17 L. L. NNP cord-274141-vujx538o 102 18 ) ) -RRB- cord-274141-vujx538o 102 19 and and CC cord-274141-vujx538o 102 20 from from IN cord-274141-vujx538o 102 21 the the DT cord-274141-vujx538o 102 22 tobacco tobacco NN cord-274141-vujx538o 102 23 plant plant NN cord-274141-vujx538o 102 24 ( ( -LRB- cord-274141-vujx538o 102 25 Nicotiana Nicotiana NNP cord-274141-vujx538o 102 26 tabacum tabacum NNP cord-274141-vujx538o 102 27 L. L. NNP cord-274141-vujx538o 102 28 ) ) -RRB- cord-274141-vujx538o 102 29 were be VBD cord-274141-vujx538o 102 30 also also RB cord-274141-vujx538o 102 31 markedly markedly RB cord-274141-vujx538o 102 32 active active JJ cord-274141-vujx538o 102 33 against against IN cord-274141-vujx538o 102 34 the the DT cord-274141-vujx538o 102 35 SARS SARS NNP cord-274141-vujx538o 102 36 - - HYPH cord-274141-vujx538o 102 37 CoV CoV NNP cord-274141-vujx538o 102 38 with with IN cord-274141-vujx538o 102 39 a a DT cord-274141-vujx538o 102 40 selectivity selectivity NN cord-274141-vujx538o 102 41 index index NN cord-274141-vujx538o 102 42 of of IN cord-274141-vujx538o 102 43 > > NNP cord-274141-vujx538o 102 44 77 77 CD cord-274141-vujx538o 102 45 and and CC cord-274141-vujx538o 102 46 > > XX cord-274141-vujx538o 102 47 59 59 CD cord-274141-vujx538o 102 48 , , , cord-274141-vujx538o 102 49 respectively respectively RB cord-274141-vujx538o 103 1 ( ( -LRB- cord-274141-vujx538o 103 2 Kumaki Kumaki NNP cord-274141-vujx538o 103 3 et et NNP cord-274141-vujx538o 103 4 al al NNP cord-274141-vujx538o 103 5 . . NNP cord-274141-vujx538o 103 6 2011 2011 CD cord-274141-vujx538o 103 7 ) ) -RRB- cord-274141-vujx538o 103 8 . . . cord-274141-vujx538o 104 1 A a DT cord-274141-vujx538o 104 2 mannose mannose NN cord-274141-vujx538o 104 3 - - HYPH cord-274141-vujx538o 104 4 specific specific JJ cord-274141-vujx538o 104 5 lectin lectin NN cord-274141-vujx538o 104 6 ( ( -LRB- cord-274141-vujx538o 104 7 agglutinin agglutinin NNP cord-274141-vujx538o 104 8 ) ) -RRB- cord-274141-vujx538o 104 9 of of IN cord-274141-vujx538o 104 10 Hippeastrum Hippeastrum NNP cord-274141-vujx538o 104 11 striatum striatum NN cord-274141-vujx538o 104 12 ( ( -LRB- cord-274141-vujx538o 104 13 Lam Lam NNP cord-274141-vujx538o 104 14 . . . cord-274141-vujx538o 104 15 ) ) -RRB- cord-274141-vujx538o 105 1 H.E.Moore h.e.moore RB cord-274141-vujx538o 105 2 prevented prevent VBN cord-274141-vujx538o 105 3 the the DT cord-274141-vujx538o 105 4 penetration penetration NN cord-274141-vujx538o 105 5 of of IN cord-274141-vujx538o 105 6 SARS SARS NNP cord-274141-vujx538o 105 7 - - HYPH cord-274141-vujx538o 105 8 CoV CoV NNP cord-274141-vujx538o 105 9 into into IN cord-274141-vujx538o 105 10 Vero Vero NNP cord-274141-vujx538o 105 11 E6 E6 NNP cord-274141-vujx538o 105 12 cells cell NNS cord-274141-vujx538o 105 13 ( ( -LRB- cord-274141-vujx538o 105 14 EC EC NNP cord-274141-vujx538o 105 15 50 50 CD cord-274141-vujx538o 105 16 2.5 2.5 CD cord-274141-vujx538o 105 17 μg μg NNS cord-274141-vujx538o 105 18 / / SYM cord-274141-vujx538o 105 19 ml ml NN cord-274141-vujx538o 105 20 at at IN cord-274141-vujx538o 105 21 4 4 CD cord-274141-vujx538o 105 22 ° ° NN cord-274141-vujx538o 105 23 C c NN cord-274141-vujx538o 105 24 ) ) -RRB- cord-274141-vujx538o 106 1 ( ( -LRB- cord-274141-vujx538o 106 2 Keyaerts Keyaerts NNP cord-274141-vujx538o 106 3 et et NNP cord-274141-vujx538o 106 4 al al NNP cord-274141-vujx538o 106 5 . . NNP cord-274141-vujx538o 106 6 2007 2007 CD cord-274141-vujx538o 106 7 ) ) -RRB- cord-274141-vujx538o 106 8 . . . cord-274141-vujx538o 107 1 SARS SARS NNP cord-274141-vujx538o 107 2 - - HYPH cord-274141-vujx538o 107 3 CoV CoV NNP cord-274141-vujx538o 107 4 spike spike NN cord-274141-vujx538o 107 5 protein protein NN cord-274141-vujx538o 107 6 contains contain VBZ cord-274141-vujx538o 107 7 12 12 CD cord-274141-vujx538o 107 8 N n CD cord-274141-vujx538o 107 9 - - HYPH cord-274141-vujx538o 107 10 glycosylation glycosylation NN cord-274141-vujx538o 107 11 sites site NNS cord-274141-vujx538o 107 12 and and CC cord-274141-vujx538o 107 13 the the DT cord-274141-vujx538o 107 14 sugars sugar NNS cord-274141-vujx538o 107 15 attached attach VBN cord-274141-vujx538o 107 16 to to IN cord-274141-vujx538o 107 17 four four CD cord-274141-vujx538o 107 18 of of IN cord-274141-vujx538o 107 19 these these DT cord-274141-vujx538o 107 20 N n CD cord-274141-vujx538o 107 21 - - HYPH cord-274141-vujx538o 107 22 glycosylation glycosylation NN cord-274141-vujx538o 107 23 sites site NNS cord-274141-vujx538o 107 24 have have VBP cord-274141-vujx538o 107 25 been be VBN cord-274141-vujx538o 107 26 identified identify VBN cord-274141-vujx538o 107 27 ( ( -LRB- cord-274141-vujx538o 107 28 Zhou Zhou NNP cord-274141-vujx538o 107 29 et et NNP cord-274141-vujx538o 107 30 al al NNP cord-274141-vujx538o 107 31 . . NNP cord-274141-vujx538o 107 32 2010 2010 CD cord-274141-vujx538o 107 33 ) ) -RRB- cord-274141-vujx538o 107 34 . . . cord-274141-vujx538o 108 1 Two two CD cord-274141-vujx538o 108 2 of of IN cord-274141-vujx538o 108 3 the the DT cord-274141-vujx538o 108 4 four four CD cord-274141-vujx538o 108 5 sugars sugar NNS cord-274141-vujx538o 108 6 were be VBD cord-274141-vujx538o 108 7 found find VBN cord-274141-vujx538o 108 8 to to TO cord-274141-vujx538o 108 9 be be VB cord-274141-vujx538o 108 10 high high JJ cord-274141-vujx538o 108 11 - - HYPH cord-274141-vujx538o 108 12 mannose mannose NN cord-274141-vujx538o 108 13 - - HYPH cord-274141-vujx538o 108 14 type type NN cord-274141-vujx538o 108 15 glycans glycan NNS cord-274141-vujx538o 108 16 and and CC cord-274141-vujx538o 108 17 the the DT cord-274141-vujx538o 108 18 other other JJ cord-274141-vujx538o 108 19 two two CD cord-274141-vujx538o 109 1 showed show VBD cord-274141-vujx538o 109 2 complex complex JJ cord-274141-vujx538o 109 3 glycan glycan NN cord-274141-vujx538o 109 4 structures structure NNS cord-274141-vujx538o 109 5 . . . cord-274141-vujx538o 110 1 The the DT cord-274141-vujx538o 110 2 potent potent JJ cord-274141-vujx538o 110 3 anti anti JJ cord-274141-vujx538o 110 4 - - JJ cord-274141-vujx538o 110 5 SARS SARS NNP cord-274141-vujx538o 110 6 - - HYPH cord-274141-vujx538o 110 7 CoV cov NN cord-274141-vujx538o 110 8 activity activity NN cord-274141-vujx538o 110 9 of of IN cord-274141-vujx538o 110 10 mannose mannose NN cord-274141-vujx538o 110 11 - - HYPH cord-274141-vujx538o 110 12 specific specific JJ cord-274141-vujx538o 110 13 plant plant NN cord-274141-vujx538o 110 14 lectins lectin NNS cord-274141-vujx538o 110 15 is be VBZ cord-274141-vujx538o 110 16 therefore therefore RB cord-274141-vujx538o 110 17 attributable attributable JJ cord-274141-vujx538o 110 18 to to IN cord-274141-vujx538o 110 19 the the DT cord-274141-vujx538o 110 20 presence presence NN cord-274141-vujx538o 110 21 of of IN cord-274141-vujx538o 110 22 high high JJ cord-274141-vujx538o 110 23 - - HYPH cord-274141-vujx538o 110 24 mannose mannose NN cord-274141-vujx538o 110 25 - - HYPH cord-274141-vujx538o 110 26 type type NN cord-274141-vujx538o 110 27 glycans glycan NNS cord-274141-vujx538o 110 28 in in IN cord-274141-vujx538o 110 29 the the DT cord-274141-vujx538o 110 30 SARS SARS NNP cord-274141-vujx538o 110 31 - - HYPH cord-274141-vujx538o 110 32 CoV CoV NNP cord-274141-vujx538o 110 33 spike spike NN cord-274141-vujx538o 110 34 protein protein NN cord-274141-vujx538o 110 35 ( ( -LRB- cord-274141-vujx538o 110 36 Keyaerts Keyaerts NNP cord-274141-vujx538o 110 37 et et NNP cord-274141-vujx538o 110 38 al al NNP cord-274141-vujx538o 110 39 . . NNP cord-274141-vujx538o 110 40 2007 2007 CD cord-274141-vujx538o 110 41 ; ; : cord-274141-vujx538o 110 42 Zhou Zhou NNP cord-274141-vujx538o 110 43 et et NNP cord-274141-vujx538o 110 44 al al NNP cord-274141-vujx538o 110 45 . . NNP cord-274141-vujx538o 110 46 2010 2010 CD cord-274141-vujx538o 110 47 ) ) -RRB- cord-274141-vujx538o 110 48 . . . cord-274141-vujx538o 111 1 Many many JJ cord-274141-vujx538o 111 2 lectins lectin NNS cord-274141-vujx538o 111 3 from from IN cord-274141-vujx538o 111 4 algae algae NN cord-274141-vujx538o 111 5 have have VBP cord-274141-vujx538o 111 6 antiviral antiviral JJ cord-274141-vujx538o 111 7 activity activity NN cord-274141-vujx538o 111 8 . . . cord-274141-vujx538o 112 1 A a DT cord-274141-vujx538o 112 2 highly highly RB cord-274141-vujx538o 112 3 potent potent JJ cord-274141-vujx538o 112 4 broad broad JJ cord-274141-vujx538o 112 5 - - HYPH cord-274141-vujx538o 112 6 spectrum spectrum NN cord-274141-vujx538o 112 7 antiviral antiviral JJ cord-274141-vujx538o 112 8 , , , cord-274141-vujx538o 112 9 griffithsin griffithsin NNP cord-274141-vujx538o 112 10 is be VBZ cord-274141-vujx538o 112 11 a a DT cord-274141-vujx538o 112 12 121-amino 121-amino CD cord-274141-vujx538o 112 13 acid acid NN cord-274141-vujx538o 112 14 red red JJ cord-274141-vujx538o 112 15 alga alga NN cord-274141-vujx538o 112 16 - - HYPH cord-274141-vujx538o 112 17 derived derive VBN cord-274141-vujx538o 112 18 lectin lectin NN cord-274141-vujx538o 112 19 that that WDT cord-274141-vujx538o 112 20 binds bind VBZ cord-274141-vujx538o 112 21 to to IN cord-274141-vujx538o 112 22 the the DT cord-274141-vujx538o 112 23 terminal terminal JJ cord-274141-vujx538o 112 24 mannose mannose NN cord-274141-vujx538o 112 25 residues residue NNS cord-274141-vujx538o 112 26 of of IN cord-274141-vujx538o 112 27 the the DT cord-274141-vujx538o 112 28 asparagine(N)-linked asparagine(N)-linked NNP cord-274141-vujx538o 112 29 Man Man NNP cord-274141-vujx538o 112 30 5 5 CD cord-274141-vujx538o 112 31 - - SYM cord-274141-vujx538o 112 32 9 9 CD cord-274141-vujx538o 112 33 GlcNAc2 GlcNAc2 NNS cord-274141-vujx538o 112 34 structures structure NNS cord-274141-vujx538o 112 35 found find VBN cord-274141-vujx538o 112 36 on on IN cord-274141-vujx538o 112 37 the the DT cord-274141-vujx538o 112 38 envelope envelope NN cord-274141-vujx538o 112 39 of of IN cord-274141-vujx538o 112 40 SARS SARS NNP cord-274141-vujx538o 112 41 - - HYPH cord-274141-vujx538o 112 42 CoV CoV NNP cord-274141-vujx538o 112 43 ( ( -LRB- cord-274141-vujx538o 112 44 Lee Lee NNP cord-274141-vujx538o 112 45 2019 2019 CD cord-274141-vujx538o 112 46 ) ) -RRB- cord-274141-vujx538o 112 47 . . . cord-274141-vujx538o 113 1 Initially initially RB cord-274141-vujx538o 113 2 identified identify VBN cord-274141-vujx538o 113 3 as as IN cord-274141-vujx538o 113 4 an an DT cord-274141-vujx538o 113 5 anti anti JJ cord-274141-vujx538o 113 6 - - JJ cord-274141-vujx538o 113 7 HIV-1 hiv-1 JJ cord-274141-vujx538o 113 8 agent agent NN cord-274141-vujx538o 113 9 with with IN cord-274141-vujx538o 113 10 EC EC NNP cord-274141-vujx538o 113 11 50 50 CD cord-274141-vujx538o 113 12 of of IN cord-274141-vujx538o 113 13 0.43 0.43 CD cord-274141-vujx538o 113 14 - - HYPH cord-274141-vujx538o 113 15 0.98 0.98 CD cord-274141-vujx538o 113 16 nM nM NNP cord-274141-vujx538o 113 17 , , , cord-274141-vujx538o 113 18 griffithsin griffithsin NNP cord-274141-vujx538o 113 19 isolated isolate VBN cord-274141-vujx538o 113 20 from from IN cord-274141-vujx538o 113 21 the the DT cord-274141-vujx538o 113 22 aqueous aqueous JJ cord-274141-vujx538o 113 23 extract extract NN cord-274141-vujx538o 113 24 of of IN cord-274141-vujx538o 113 25 the the DT cord-274141-vujx538o 113 26 red red JJ cord-274141-vujx538o 113 27 algae algae NN cord-274141-vujx538o 113 28 Griffithsia Griffithsia NNP cord-274141-vujx538o 113 29 corallinoides corallinoides NNP cord-274141-vujx538o 113 30 ( ( -LRB- cord-274141-vujx538o 113 31 L. L. NNP cord-274141-vujx538o 113 32 ) ) -RRB- cord-274141-vujx538o 114 1 Trevisan Trevisan NNP cord-274141-vujx538o 114 2 found find VBD cord-274141-vujx538o 114 3 off off IN cord-274141-vujx538o 114 4 the the DT cord-274141-vujx538o 114 5 eastern eastern JJ cord-274141-vujx538o 114 6 shore shore NN cord-274141-vujx538o 114 7 of of IN cord-274141-vujx538o 114 8 Chatham Chatham NNP cord-274141-vujx538o 114 9 Island Island NNP cord-274141-vujx538o 114 10 , , , cord-274141-vujx538o 114 11 New New NNP cord-274141-vujx538o 114 12 Zealand Zealand NNP cord-274141-vujx538o 114 13 , , , cord-274141-vujx538o 114 14 is be VBZ cord-274141-vujx538o 114 15 a a DT cord-274141-vujx538o 114 16 12.7-kDa 12.7-kda CD cord-274141-vujx538o 114 17 lectin lectin NN cord-274141-vujx538o 114 18 that that WDT cord-274141-vujx538o 114 19 also also RB cord-274141-vujx538o 114 20 inhibits inhibit VBZ cord-274141-vujx538o 114 21 SARS SARS NNP cord-274141-vujx538o 114 22 - - HYPH cord-274141-vujx538o 114 23 CoV CoV NNP cord-274141-vujx538o 114 24 ( ( -LRB- cord-274141-vujx538o 114 25 EC EC NNP cord-274141-vujx538o 114 26 50 50 CD cord-274141-vujx538o 114 27 0.048 0.048 CD cord-274141-vujx538o 114 28 - - SYM cord-274141-vujx538o 114 29 960 960 CD cord-274141-vujx538o 114 30 nM nM NNP cord-274141-vujx538o 114 31 ) ) -RRB- cord-274141-vujx538o 114 32 , , , cord-274141-vujx538o 114 33 various various JJ cord-274141-vujx538o 114 34 avian avian JJ cord-274141-vujx538o 114 35 CoV cov NN cord-274141-vujx538o 114 36 subtypes subtype NNS cord-274141-vujx538o 114 37 ( ( -LRB- cord-274141-vujx538o 114 38 EC EC NNP cord-274141-vujx538o 114 39 50 50 CD cord-274141-vujx538o 114 40 0.032 0.032 CD cord-274141-vujx538o 114 41 - - HYPH cord-274141-vujx538o 114 42 0.57 0.57 CD cord-274141-vujx538o 114 43 nM nM NNP cord-274141-vujx538o 114 44 ) ) -RRB- cord-274141-vujx538o 114 45 , , , cord-274141-vujx538o 114 46 bovine bovine JJ cord-274141-vujx538o 114 47 CoV cov NN cord-274141-vujx538o 114 48 ( ( -LRB- cord-274141-vujx538o 114 49 EC EC NNP cord-274141-vujx538o 114 50 50 50 CD cord-274141-vujx538o 114 51 0.057 0.057 CD cord-274141-vujx538o 114 52 nM nM NNP cord-274141-vujx538o 114 53 ) ) -RRB- cord-274141-vujx538o 114 54 , , , cord-274141-vujx538o 114 55 puffinosis puffinosis NNP cord-274141-vujx538o 114 56 CoV CoV NNP cord-274141-vujx538o 114 57 ( ( -LRB- cord-274141-vujx538o 114 58 EC EC NNP cord-274141-vujx538o 114 59 50 50 CD cord-274141-vujx538o 114 60 0.57 0.57 CD cord-274141-vujx538o 114 61 nM nM NNP cord-274141-vujx538o 114 62 ) ) -RRB- cord-274141-vujx538o 114 63 , , , cord-274141-vujx538o 114 64 and and CC cord-274141-vujx538o 114 65 HCoV HCoV NNP cord-274141-vujx538o 114 66 mutants mutant NNS cord-274141-vujx538o 114 67 with with IN cord-274141-vujx538o 114 68 EC EC NNP cord-274141-vujx538o 114 69 50 50 CD cord-274141-vujx538o 114 70 of of IN cord-274141-vujx538o 114 71 0.16 0.16 CD cord-274141-vujx538o 114 72 nM nm NN cord-274141-vujx538o 114 73 ( ( -LRB- cord-274141-vujx538o 114 74 Mitchell Mitchell NNP cord-274141-vujx538o 114 75 et et NNP cord-274141-vujx538o 114 76 al al NNP cord-274141-vujx538o 114 77 . . . cord-274141-vujx538o 114 78 2017 2017 CD cord-274141-vujx538o 114 79 ) ) -RRB- cord-274141-vujx538o 114 80 . . . cord-274141-vujx538o 115 1 Some some DT cord-274141-vujx538o 115 2 viruses virus NNS cord-274141-vujx538o 115 3 such such JJ cord-274141-vujx538o 115 4 as as IN cord-274141-vujx538o 115 5 Ebola Ebola NNP cord-274141-vujx538o 115 6 and and CC cord-274141-vujx538o 115 7 SARS SARS NNP cord-274141-vujx538o 115 8 - - HYPH cord-274141-vujx538o 115 9 COV COV NNP cord-274141-vujx538o 115 10 use use VBP cord-274141-vujx538o 115 11 cathepsins cathepsin NNS cord-274141-vujx538o 115 12 , , , cord-274141-vujx538o 115 13 a a DT cord-274141-vujx538o 115 14 family family NN cord-274141-vujx538o 115 15 of of IN cord-274141-vujx538o 115 16 proteases protease NNS cord-274141-vujx538o 115 17 , , , cord-274141-vujx538o 115 18 to to TO cord-274141-vujx538o 115 19 infect infect VB cord-274141-vujx538o 115 20 host host NN cord-274141-vujx538o 115 21 cells cell NNS cord-274141-vujx538o 116 1 ( ( -LRB- cord-274141-vujx538o 116 2 Huang Huang NNP cord-274141-vujx538o 116 3 et et NNP cord-274141-vujx538o 116 4 al al NNP cord-274141-vujx538o 116 5 . . . cord-274141-vujx538o 116 6 2006 2006 CD cord-274141-vujx538o 116 7 ) ) -RRB- cord-274141-vujx538o 116 8 . . . cord-274141-vujx538o 117 1 Inhibitors inhibitor NNS cord-274141-vujx538o 117 2 of of IN cord-274141-vujx538o 117 3 cathepsin cathepsin NN cord-274141-vujx538o 117 4 L L NNP cord-274141-vujx538o 117 5 prevent prevent VBP cord-274141-vujx538o 117 6 entry entry NN cord-274141-vujx538o 117 7 of of IN cord-274141-vujx538o 117 8 SARS SARS NNP cord-274141-vujx538o 117 9 - - HYPH cord-274141-vujx538o 117 10 CoV CoV NNP cord-274141-vujx538o 117 11 into into IN cord-274141-vujx538o 117 12 target target NN cord-274141-vujx538o 117 13 cells cell NNS cord-274141-vujx538o 118 1 ( ( -LRB- cord-274141-vujx538o 118 2 Simmons Simmons NNP cord-274141-vujx538o 118 3 et et NNP cord-274141-vujx538o 118 4 al al NNP cord-274141-vujx538o 118 5 . . NNP cord-274141-vujx538o 118 6 2005 2005 CD cord-274141-vujx538o 118 7 ) ) -RRB- cord-274141-vujx538o 118 8 . . . cord-274141-vujx538o 119 1 Unfortunately unfortunately RB cord-274141-vujx538o 119 2 , , , cord-274141-vujx538o 119 3 many many JJ cord-274141-vujx538o 119 4 cathepsin cathepsin NN cord-274141-vujx538o 119 5 inhibitors inhibitor NNS cord-274141-vujx538o 119 6 are be VBP cord-274141-vujx538o 119 7 non non JJ cord-274141-vujx538o 119 8 - - JJ cord-274141-vujx538o 119 9 selective selective JJ cord-274141-vujx538o 119 10 ( ( -LRB- cord-274141-vujx538o 119 11 Zhou Zhou NNP cord-274141-vujx538o 119 12 et et NNP cord-274141-vujx538o 119 13 al al NNP cord-274141-vujx538o 119 14 . . . cord-274141-vujx538o 119 15 2016 2016 CD cord-274141-vujx538o 119 16 ) ) -RRB- cord-274141-vujx538o 119 17 . . . cord-274141-vujx538o 120 1 Leupeptin Leupeptin NNP cord-274141-vujx538o 120 2 ( ( -LRB- cord-274141-vujx538o 120 3 1 1 CD cord-274141-vujx538o 120 4 ) ) -RRB- cord-274141-vujx538o 120 5 , , , cord-274141-vujx538o 120 6 also also RB cord-274141-vujx538o 120 7 known know VBN cord-274141-vujx538o 120 8 as as IN cord-274141-vujx538o 120 9 N n CD cord-274141-vujx538o 120 10 - - HYPH cord-274141-vujx538o 120 11 acetyl acetyl NNP cord-274141-vujx538o 120 12 - - HYPH cord-274141-vujx538o 120 13 L l NN cord-274141-vujx538o 120 14 - - HYPH cord-274141-vujx538o 120 15 leucyl leucyl NNP cord-274141-vujx538o 120 16 - - HYPH cord-274141-vujx538o 120 17 L l NN cord-274141-vujx538o 120 18 - - HYPH cord-274141-vujx538o 120 19 leucyl leucyl NNP cord-274141-vujx538o 120 20 - - HYPH cord-274141-vujx538o 120 21 L l NN cord-274141-vujx538o 120 22 - - HYPH cord-274141-vujx538o 120 23 argininal argininal JJ cord-274141-vujx538o 120 24 , , , cord-274141-vujx538o 120 25 is be VBZ cord-274141-vujx538o 120 26 protease protease NN cord-274141-vujx538o 120 27 inhibitor inhibitor NN cord-274141-vujx538o 120 28 produced produce VBN cord-274141-vujx538o 120 29 by by IN cord-274141-vujx538o 120 30 actinomycetes actinomycetes NNP cord-274141-vujx538o 120 31 and and CC cord-274141-vujx538o 120 32 isolated isolate VBN cord-274141-vujx538o 120 33 from from IN cord-274141-vujx538o 120 34 a a DT cord-274141-vujx538o 120 35 strain strain NN cord-274141-vujx538o 120 36 of of IN cord-274141-vujx538o 120 37 Streptomyces Streptomyces NNP cord-274141-vujx538o 120 38 exfoliatus exfoliatus NNP cord-274141-vujx538o 120 39 ( ( -LRB- cord-274141-vujx538o 120 40 Waksman Waksman NNP cord-274141-vujx538o 120 41 and and CC cord-274141-vujx538o 120 42 Curtis Curtis NNP cord-274141-vujx538o 120 43 ) ) -RRB- cord-274141-vujx538o 121 1 Waksman Waksman NNP cord-274141-vujx538o 121 2 and and CC cord-274141-vujx538o 121 3 Henrici Henrici NNP cord-274141-vujx538o 121 4 , , , cord-274141-vujx538o 121 5 which which WDT cord-274141-vujx538o 121 6 can can MD cord-274141-vujx538o 121 7 inhibit inhibit VB cord-274141-vujx538o 121 8 cysteine cysteine NN cord-274141-vujx538o 121 9 , , , cord-274141-vujx538o 121 10 serine serine NN cord-274141-vujx538o 121 11 , , , cord-274141-vujx538o 121 12 and and CC cord-274141-vujx538o 121 13 threonine threonine NN cord-274141-vujx538o 121 14 peptidases peptidase NNS cord-274141-vujx538o 121 15 . . . cord-274141-vujx538o 122 1 Simmons Simmons NNP cord-274141-vujx538o 122 2 et et NNP cord-274141-vujx538o 122 3 al al NNP cord-274141-vujx538o 122 4 . . . cord-274141-vujx538o 123 1 ( ( -LRB- cord-274141-vujx538o 123 2 2005 2005 CD cord-274141-vujx538o 123 3 ) ) -RRB- cord-274141-vujx538o 123 4 showed show VBD cord-274141-vujx538o 123 5 that that IN cord-274141-vujx538o 123 6 inhibitors inhibitor NNS cord-274141-vujx538o 123 7 of of IN cord-274141-vujx538o 123 8 proteases protease NNS cord-274141-vujx538o 123 9 such such JJ cord-274141-vujx538o 123 10 as as IN cord-274141-vujx538o 123 11 leupeptin leupeptin NNP cord-274141-vujx538o 123 12 act act NNP cord-274141-vujx538o 123 13 as as IN cord-274141-vujx538o 123 14 potent potent JJ cord-274141-vujx538o 123 15 inhibitors inhibitor NNS cord-274141-vujx538o 123 16 of of IN cord-274141-vujx538o 123 17 SARS SARS NNP cord-274141-vujx538o 123 18 - - HYPH cord-274141-vujx538o 123 19 CoV CoV NNP cord-274141-vujx538o 123 20 entry entry NN cord-274141-vujx538o 123 21 into into IN cord-274141-vujx538o 123 22 host host NN cord-274141-vujx538o 123 23 cells cell NNS cord-274141-vujx538o 123 24 . . . cord-274141-vujx538o 124 1 SARS SARS NNP cord-274141-vujx538o 124 2 - - HYPH cord-274141-vujx538o 124 3 CoV CoV NNP cord-274141-vujx538o 124 4 spike spike NN cord-274141-vujx538o 124 5 protein protein NN cord-274141-vujx538o 124 6 - - HYPH cord-274141-vujx538o 124 7 driven drive VBN cord-274141-vujx538o 124 8 virus virus NN cord-274141-vujx538o 124 9 - - HYPH cord-274141-vujx538o 124 10 cell cell NN cord-274141-vujx538o 124 11 fusion fusion NN cord-274141-vujx538o 124 12 is be VBZ cord-274141-vujx538o 124 13 inhibited inhibit VBN cord-274141-vujx538o 124 14 by by IN cord-274141-vujx538o 124 15 1 1 CD cord-274141-vujx538o 124 16 , , , cord-274141-vujx538o 124 17 which which WDT cord-274141-vujx538o 124 18 exhibited exhibit VBD cord-274141-vujx538o 124 19 a a DT cord-274141-vujx538o 124 20 dose dose NN cord-274141-vujx538o 124 21 - - HYPH cord-274141-vujx538o 124 22 dependent dependent JJ cord-274141-vujx538o 124 23 inhibition inhibition NN cord-274141-vujx538o 124 24 of of IN cord-274141-vujx538o 124 25 SARS SARS NNP cord-274141-vujx538o 124 26 - - HYPH cord-274141-vujx538o 124 27 CoV CoV NNP cord-274141-vujx538o 124 28 infection infection NN cord-274141-vujx538o 124 29 ) ) -RRB- cord-274141-vujx538o 125 1 ( ( -LRB- cord-274141-vujx538o 125 2 IC IC NNP cord-274141-vujx538o 125 3 95 95 CD cord-274141-vujx538o 125 4 15.2 15.2 CD cord-274141-vujx538o 125 5 μM μM NNP cord-274141-vujx538o 125 6 ) ) -RRB- cord-274141-vujx538o 125 7 . . . cord-274141-vujx538o 126 1 This this DT cord-274141-vujx538o 126 2 inhibition inhibition NN cord-274141-vujx538o 126 3 is be VBZ cord-274141-vujx538o 126 4 the the DT cord-274141-vujx538o 126 5 result result NN cord-274141-vujx538o 126 6 of of IN cord-274141-vujx538o 126 7 an an DT cord-274141-vujx538o 126 8 absolute absolute JJ cord-274141-vujx538o 126 9 requirement requirement NN cord-274141-vujx538o 126 10 in in IN cord-274141-vujx538o 126 11 cell cell NN cord-274141-vujx538o 126 12 lines line NNS cord-274141-vujx538o 126 13 for for IN cord-274141-vujx538o 126 14 endosomal endosomal NNP cord-274141-vujx538o 126 15 processing processing NN cord-274141-vujx538o 126 16 of of IN cord-274141-vujx538o 126 17 the the DT cord-274141-vujx538o 126 18 SARS SARS NNP cord-274141-vujx538o 126 19 - - HYPH cord-274141-vujx538o 126 20 CoV CoV NNP cord-274141-vujx538o 126 21 spike spike NN cord-274141-vujx538o 126 22 protein protein NN cord-274141-vujx538o 126 23 by by IN cord-274141-vujx538o 126 24 cathepsin cathepsin NN cord-274141-vujx538o 126 25 L l NN cord-274141-vujx538o 126 26 during during IN cord-274141-vujx538o 126 27 entry entry NN cord-274141-vujx538o 126 28 into into IN cord-274141-vujx538o 126 29 the the DT cord-274141-vujx538o 126 30 target target NN cord-274141-vujx538o 126 31 cell cell NN cord-274141-vujx538o 126 32 ) ) -RRB- cord-274141-vujx538o 126 33 . . . cord-274141-vujx538o 127 1 The the DT cord-274141-vujx538o 127 2 oligopeptide oligopeptide NN cord-274141-vujx538o 127 3 antipain antipain NN cord-274141-vujx538o 127 4 ( ( -LRB- cord-274141-vujx538o 127 5 2 2 CD cord-274141-vujx538o 127 6 ) ) -RRB- cord-274141-vujx538o 127 7 , , , cord-274141-vujx538o 127 8 an an DT cord-274141-vujx538o 127 9 inhibitor inhibitor NN cord-274141-vujx538o 127 10 of of IN cord-274141-vujx538o 127 11 trypsin trypsin NN cord-274141-vujx538o 127 12 and and CC cord-274141-vujx538o 127 13 papain papain NN cord-274141-vujx538o 127 14 , , , cord-274141-vujx538o 127 15 isolated isolate VBN cord-274141-vujx538o 127 16 from from IN cord-274141-vujx538o 127 17 actinomycetes actinomycetes NNP cord-274141-vujx538o 127 18 inhibited inhibited JJ cord-274141-vujx538o 127 19 SARS SARS NNP cord-274141-vujx538o 127 20 - - HYPH cord-274141-vujx538o 127 21 COV COV NNP cord-274141-vujx538o 127 22 entry entry NN cord-274141-vujx538o 127 23 into into IN cord-274141-vujx538o 127 24 host host NN cord-274141-vujx538o 127 25 cells cell NNS cord-274141-vujx538o 128 1 ( ( -LRB- cord-274141-vujx538o 128 2 Simmons Simmons NNP cord-274141-vujx538o 128 3 et et NNP cord-274141-vujx538o 128 4 al al NNP cord-274141-vujx538o 128 5 . . NNP cord-274141-vujx538o 128 6 2005 2005 CD cord-274141-vujx538o 128 7 ) ) -RRB- cord-274141-vujx538o 128 8 . . . cord-274141-vujx538o 129 1 ( ( -LRB- cord-274141-vujx538o 129 2 Dong Dong NNP cord-274141-vujx538o 129 3 et et FW cord-274141-vujx538o 129 4 al al NNP cord-274141-vujx538o 129 5 . . . cord-274141-vujx538o 129 6 2016 2016 CD cord-274141-vujx538o 129 7 ; ; : cord-274141-vujx538o 129 8 Zhou Zhou NNP cord-274141-vujx538o 129 9 et et NNP cord-274141-vujx538o 129 10 al al NNP cord-274141-vujx538o 129 11 . . NNP cord-274141-vujx538o 129 12 , , , cord-274141-vujx538o 129 13 2020a 2020a CD cord-274141-vujx538o 129 14 , , , cord-274141-vujx538o 129 15 b b LS cord-274141-vujx538o 129 16 ) ) -RRB- cord-274141-vujx538o 129 17 , , , cord-274141-vujx538o 129 18 and and CC cord-274141-vujx538o 130 1 Cassia Cassia NNP cord-274141-vujx538o 130 2 tora tora NNP cord-274141-vujx538o 130 3 L. L. NNP cord-274141-vujx538o 130 4 Emodin Emodin NNP cord-274141-vujx538o 130 5 inhibited inhibit VBD cord-274141-vujx538o 130 6 SARS SARS NNP cord-274141-vujx538o 130 7 - - HYPH cord-274141-vujx538o 130 8 CoV CoV NNP cord-274141-vujx538o 130 9 via via IN cord-274141-vujx538o 130 10 the the DT cord-274141-vujx538o 130 11 blockage blockage NN cord-274141-vujx538o 130 12 of of IN cord-274141-vujx538o 130 13 viral viral JJ cord-274141-vujx538o 130 14 entry entry NN cord-274141-vujx538o 130 15 by by IN cord-274141-vujx538o 130 16 binding bind VBG cord-274141-vujx538o 130 17 to to IN cord-274141-vujx538o 130 18 the the DT cord-274141-vujx538o 130 19 spike spike NN cord-274141-vujx538o 130 20 proteins protein NNS cord-274141-vujx538o 130 21 and and CC cord-274141-vujx538o 130 22 interfering interfere VBG cord-274141-vujx538o 130 23 with with IN cord-274141-vujx538o 130 24 SARS SARS NNP cord-274141-vujx538o 130 25 - - HYPH cord-274141-vujx538o 130 26 CoV CoV NNP cord-274141-vujx538o 130 27 3CL 3CL NNP cord-274141-vujx538o 130 28 pro pro JJ cord-274141-vujx538o 130 29 activity activity NN cord-274141-vujx538o 130 30 ( ( -LRB- cord-274141-vujx538o 130 31 Hyun Hyun NNP cord-274141-vujx538o 130 32 et et NNP cord-274141-vujx538o 130 33 al al NNP cord-274141-vujx538o 130 34 . . NNP cord-274141-vujx538o 130 35 2009 2009 CD cord-274141-vujx538o 130 36 ) ) -RRB- cord-274141-vujx538o 130 37 . . . cord-274141-vujx538o 131 1 In in IN cord-274141-vujx538o 131 2 assays assay NNS cord-274141-vujx538o 131 3 involving involve VBG cord-274141-vujx538o 131 4 SARS SARS NNP cord-274141-vujx538o 131 5 - - HYPH cord-274141-vujx538o 131 6 CoV CoV NNP cord-274141-vujx538o 131 7 and and CC cord-274141-vujx538o 131 8 HCoV HCoV NNP cord-274141-vujx538o 131 9 - - HYPH cord-274141-vujx538o 131 10 OC43 OC43 NNP cord-274141-vujx538o 131 11 , , , cord-274141-vujx538o 131 12 emodin emodin NN cord-274141-vujx538o 131 13 in in IN cord-274141-vujx538o 131 14 a a DT cord-274141-vujx538o 131 15 dose dose NN cord-274141-vujx538o 131 16 - - HYPH cord-274141-vujx538o 131 17 dependent dependent JJ cord-274141-vujx538o 131 18 manner manner NN cord-274141-vujx538o 131 19 significantly significantly RB cord-274141-vujx538o 131 20 blocked block VBD cord-274141-vujx538o 131 21 the the DT cord-274141-vujx538o 131 22 interaction interaction NN cord-274141-vujx538o 131 23 between between IN cord-274141-vujx538o 131 24 the the DT cord-274141-vujx538o 131 25 SARS SARS NNP cord-274141-vujx538o 131 26 - - HYPH cord-274141-vujx538o 131 27 CoV CoV NNP cord-274141-vujx538o 131 28 spike spike NN cord-274141-vujx538o 131 29 protein protein NN cord-274141-vujx538o 131 30 and and CC cord-274141-vujx538o 131 31 ACE2 ACE2 NNP cord-274141-vujx538o 131 32 ( ( -LRB- cord-274141-vujx538o 131 33 a a DT cord-274141-vujx538o 131 34 functional functional JJ cord-274141-vujx538o 131 35 SARS SARS NNP cord-274141-vujx538o 131 36 - - HYPH cord-274141-vujx538o 131 37 CoV CoV NNP cord-274141-vujx538o 131 38 receptor receptor NN cord-274141-vujx538o 131 39 ) ) -RRB- cord-274141-vujx538o 131 40 , , , cord-274141-vujx538o 131 41 inhibited inhibit VBD cord-274141-vujx538o 131 42 the the DT cord-274141-vujx538o 131 43 3a 3a NNP cord-274141-vujx538o 131 44 ion ion NNP cord-274141-vujx538o 131 45 channel channel NNP cord-274141-vujx538o 131 46 ( ( -LRB- cord-274141-vujx538o 131 47 K k NN cord-274141-vujx538o 131 48 1/2 1/2 CD cord-274141-vujx538o 131 49 value value NN cord-274141-vujx538o 131 50 of of IN cord-274141-vujx538o 131 51 about about RB cord-274141-vujx538o 131 52 20 20 CD cord-274141-vujx538o 131 53 μM μm CD cord-274141-vujx538o 131 54 ) ) -RRB- cord-274141-vujx538o 131 55 , , , cord-274141-vujx538o 131 56 and and CC cord-274141-vujx538o 131 57 stopped stop VBD cord-274141-vujx538o 131 58 new new JJ cord-274141-vujx538o 131 59 coronavirus coronavirus NN cord-274141-vujx538o 131 60 release release NN cord-274141-vujx538o 131 61 ( ( -LRB- cord-274141-vujx538o 131 62 Dong Dong NNP cord-274141-vujx538o 131 63 et et FW cord-274141-vujx538o 131 64 al al NNP cord-274141-vujx538o 131 65 . . . cord-274141-vujx538o 131 66 2016 2016 CD cord-274141-vujx538o 131 67 ; ; : cord-274141-vujx538o 131 68 Ho Ho NNP cord-274141-vujx538o 131 69 et et FW cord-274141-vujx538o 131 70 al al NNP cord-274141-vujx538o 131 71 . . NNP cord-274141-vujx538o 131 72 2007 2007 CD cord-274141-vujx538o 131 73 ) ) -RRB- cord-274141-vujx538o 131 74 . . . cord-274141-vujx538o 132 1 SARS SARS NNP cord-274141-vujx538o 132 2 - - HYPH cord-274141-vujx538o 132 3 CoV-2 CoV-2 NNP cord-274141-vujx538o 132 4 spike spike NN cord-274141-vujx538o 132 5 protein protein NN cord-274141-vujx538o 132 6 directly directly RB cord-274141-vujx538o 132 7 binds bind VBZ cord-274141-vujx538o 132 8 to to IN cord-274141-vujx538o 132 9 the the DT cord-274141-vujx538o 132 10 host host NN cord-274141-vujx538o 132 11 cell cell NN cord-274141-vujx538o 132 12 surface surface NN cord-274141-vujx538o 132 13 ACE2 ACE2 NNP cord-274141-vujx538o 132 14 receptor receptor NN cord-274141-vujx538o 132 15 facilitating facilitate VBG cord-274141-vujx538o 132 16 virus virus NN cord-274141-vujx538o 132 17 entry entry NN cord-274141-vujx538o 132 18 and and CC cord-274141-vujx538o 132 19 replication replication NN cord-274141-vujx538o 132 20 . . . cord-274141-vujx538o 133 1 Corollary corollary JJ cord-274141-vujx538o 133 2 , , , cord-274141-vujx538o 133 3 emodin emodin NNS cord-274141-vujx538o 133 4 can can MD cord-274141-vujx538o 133 5 be be VB cord-274141-vujx538o 133 6 considered consider VBN cord-274141-vujx538o 133 7 a a DT cord-274141-vujx538o 133 8 potential potential JJ cord-274141-vujx538o 133 9 lead lead NN cord-274141-vujx538o 133 10 therapeutic therapeutic JJ cord-274141-vujx538o 133 11 agent agent NN cord-274141-vujx538o 133 12 in in IN cord-274141-vujx538o 133 13 the the DT cord-274141-vujx538o 133 14 treatment treatment NN cord-274141-vujx538o 133 15 of of IN cord-274141-vujx538o 133 16 SARS SARS NNP cord-274141-vujx538o 133 17 - - HYPH cord-274141-vujx538o 133 18 CoV-2 CoV-2 NNP cord-274141-vujx538o 133 19 infection infection NN cord-274141-vujx538o 133 20 . . . cord-274141-vujx538o 134 1 Experimental experimental JJ cord-274141-vujx538o 134 2 data datum NNS cord-274141-vujx538o 134 3 now now RB cord-274141-vujx538o 134 4 suggest suggest VBP cord-274141-vujx538o 134 5 that that IN cord-274141-vujx538o 134 6 combining combine VBG cord-274141-vujx538o 134 7 emodin emodin NNS cord-274141-vujx538o 134 8 and and CC cord-274141-vujx538o 134 9 the the DT cord-274141-vujx538o 134 10 drug drug NN cord-274141-vujx538o 134 11 toremifene toremifene NNP cord-274141-vujx538o 134 12 , , , cord-274141-vujx538o 134 13 a a DT cord-274141-vujx538o 134 14 first first JJ cord-274141-vujx538o 134 15 - - HYPH cord-274141-vujx538o 134 16 generation generation NN cord-274141-vujx538o 134 17 non non JJ cord-274141-vujx538o 134 18 - - JJ cord-274141-vujx538o 134 19 steroidal steroidal JJ cord-274141-vujx538o 134 20 selective selective JJ cord-274141-vujx538o 134 21 estrogen estrogen NN cord-274141-vujx538o 134 22 receptor receptor NN cord-274141-vujx538o 134 23 modulator modulator NN cord-274141-vujx538o 134 24 for for IN cord-274141-vujx538o 134 25 the the DT cord-274141-vujx538o 134 26 treatment treatment NN cord-274141-vujx538o 134 27 of of IN cord-274141-vujx538o 134 28 metastatic metastatic JJ cord-274141-vujx538o 134 29 breast breast NN cord-274141-vujx538o 134 30 cancer cancer NN cord-274141-vujx538o 134 31 , , , cord-274141-vujx538o 134 32 provides provide VBZ cord-274141-vujx538o 134 33 a a DT cord-274141-vujx538o 134 34 potential potential JJ cord-274141-vujx538o 134 35 therapeutic therapeutic JJ cord-274141-vujx538o 134 36 approach approach NN cord-274141-vujx538o 134 37 for for IN cord-274141-vujx538o 134 38 SARS SARS NNP cord-274141-vujx538o 134 39 - - HYPH cord-274141-vujx538o 134 40 CoV-2 CoV-2 NNP cord-274141-vujx538o 134 41 ( ( -LRB- cord-274141-vujx538o 134 42 Zhou Zhou NNP cord-274141-vujx538o 134 43 et et NNP cord-274141-vujx538o 134 44 al al NNP cord-274141-vujx538o 134 45 . . NNP cord-274141-vujx538o 134 46 , , , cord-274141-vujx538o 134 47 2020a 2020a CD cord-274141-vujx538o 134 48 , , , cord-274141-vujx538o 134 49 b b LS cord-274141-vujx538o 134 50 ) ) -RRB- cord-274141-vujx538o 134 51 . . . cord-274141-vujx538o 135 1 Terpenoids Terpenoids NNP cord-274141-vujx538o 135 2 isolated isolate VBN cord-274141-vujx538o 135 3 from from IN cord-274141-vujx538o 135 4 medicinal medicinal JJ cord-274141-vujx538o 135 5 plants plant NNS cord-274141-vujx538o 135 6 have have VBP cord-274141-vujx538o 135 7 attracted attract VBN cord-274141-vujx538o 135 8 attention attention NN cord-274141-vujx538o 135 9 because because IN cord-274141-vujx538o 135 10 many many JJ cord-274141-vujx538o 135 11 of of IN cord-274141-vujx538o 135 12 them -PRON- PRP cord-274141-vujx538o 135 13 exhibit exhibit VBP cord-274141-vujx538o 135 14 specific specific JJ cord-274141-vujx538o 135 15 in in IN cord-274141-vujx538o 135 16 vitro vitro FW cord-274141-vujx538o 135 17 antiviral antiviral JJ cord-274141-vujx538o 135 18 effect effect NN cord-274141-vujx538o 135 19 against against IN cord-274141-vujx538o 135 20 SARS SARS NNP cord-274141-vujx538o 135 21 - - HYPH cord-274141-vujx538o 135 22 CoV CoV NNP cord-274141-vujx538o 135 23 ( ( -LRB- cord-274141-vujx538o 135 24 Wen Wen NNP cord-274141-vujx538o 135 25 et et FW cord-274141-vujx538o 135 26 al al NNP cord-274141-vujx538o 135 27 . . NNP cord-274141-vujx538o 135 28 2007 2007 CD cord-274141-vujx538o 135 29 ) ) -RRB- cord-274141-vujx538o 135 30 . . . cord-274141-vujx538o 136 1 Triterpenoids triterpenoid NNS cord-274141-vujx538o 136 2 inhibit inhibit VBP cord-274141-vujx538o 136 3 the the DT cord-274141-vujx538o 136 4 entry entry NN cord-274141-vujx538o 136 5 of of IN cord-274141-vujx538o 136 6 Ebola Ebola NNP cord-274141-vujx538o 136 7 , , , cord-274141-vujx538o 136 8 Marburg Marburg NNP cord-274141-vujx538o 136 9 , , , cord-274141-vujx538o 136 10 HIV HIV NNP cord-274141-vujx538o 136 11 , , , cord-274141-vujx538o 136 12 and and CC cord-274141-vujx538o 136 13 influenza influenza VB cord-274141-vujx538o 136 14 A a DT cord-274141-vujx538o 136 15 viruses virus NNS cord-274141-vujx538o 136 16 with with IN cord-274141-vujx538o 136 17 distinct distinct JJ cord-274141-vujx538o 136 18 structure structure NN cord-274141-vujx538o 136 19 - - HYPH cord-274141-vujx538o 136 20 activity activity NN cord-274141-vujx538o 136 21 relationships relationship NNS cord-274141-vujx538o 136 22 ( ( -LRB- cord-274141-vujx538o 136 23 Si si FW cord-274141-vujx538o 136 24 et et FW cord-274141-vujx538o 136 25 al al NNP cord-274141-vujx538o 136 26 . . . cord-274141-vujx538o 136 27 2018 2018 CD cord-274141-vujx538o 136 28 ) ) -RRB- cord-274141-vujx538o 136 29 . . . cord-274141-vujx538o 137 1 These these DT cord-274141-vujx538o 137 2 natural natural JJ cord-274141-vujx538o 137 3 agents agent NNS cord-274141-vujx538o 137 4 modulate modulate VBP cord-274141-vujx538o 137 5 a a DT cord-274141-vujx538o 137 6 broad broad JJ cord-274141-vujx538o 137 7 range range NN cord-274141-vujx538o 137 8 of of IN cord-274141-vujx538o 137 9 virus virus NN cord-274141-vujx538o 137 10 - - HYPH cord-274141-vujx538o 137 11 host host NN cord-274141-vujx538o 137 12 fusion fusion NN cord-274141-vujx538o 137 13 functions function NNS cord-274141-vujx538o 137 14 via via IN cord-274141-vujx538o 137 15 wrapping wrap VBG cord-274141-vujx538o 137 16 the the DT cord-274141-vujx538o 137 17 heptad heptad NN cord-274141-vujx538o 137 18 repeat repeat NN cord-274141-vujx538o 137 19 2 2 CD cord-274141-vujx538o 137 20 domain domain NN cord-274141-vujx538o 137 21 prevalent prevalent JJ cord-274141-vujx538o 137 22 in in IN cord-274141-vujx538o 137 23 viral viral JJ cord-274141-vujx538o 137 24 envelopes envelope NNS cord-274141-vujx538o 137 25 . . . cord-274141-vujx538o 138 1 Euphorbia Euphorbia NNP cord-274141-vujx538o 138 2 neriifolia neriifolia NNP cord-274141-vujx538o 138 3 L. L. NNP cord-274141-vujx538o 138 4 produces produce VBZ cord-274141-vujx538o 138 5 22 22 CD cord-274141-vujx538o 138 6 triterpenoids triterpenoid NNS cord-274141-vujx538o 138 7 with with IN cord-274141-vujx538o 138 8 stronger strong JJR cord-274141-vujx538o 138 9 activity activity NN cord-274141-vujx538o 138 10 against against IN cord-274141-vujx538o 138 11 HCoVs hcovs CD cord-274141-vujx538o 138 12 than than IN cord-274141-vujx538o 138 13 actinomycin actinomycin NNS cord-274141-vujx538o 138 14 D D NNP cord-274141-vujx538o 138 15 ( ( -LRB- cord-274141-vujx538o 138 16 Chang Chang NNP cord-274141-vujx538o 138 17 et et NNP cord-274141-vujx538o 138 18 al al NNP cord-274141-vujx538o 138 19 . . NNP cord-274141-vujx538o 138 20 2012 2012 CD cord-274141-vujx538o 138 21 ) ) -RRB- cord-274141-vujx538o 138 22 . . . cord-274141-vujx538o 139 1 Saikosaponins saikosaponin NNS cord-274141-vujx538o 139 2 represent represent VBP cord-274141-vujx538o 139 3 a a DT cord-274141-vujx538o 139 4 group group NN cord-274141-vujx538o 139 5 of of IN cord-274141-vujx538o 139 6 oleanane oleanane NN cord-274141-vujx538o 139 7 derivatives derivative NNS cord-274141-vujx538o 139 8 , , , cord-274141-vujx538o 139 9 usually usually RB cord-274141-vujx538o 139 10 as as IN cord-274141-vujx538o 139 11 glucosides glucoside NNS cord-274141-vujx538o 139 12 , , , cord-274141-vujx538o 139 13 found find VBN cord-274141-vujx538o 139 14 in in IN cord-274141-vujx538o 139 15 medicinal medicinal JJ cord-274141-vujx538o 139 16 plants plant NNS cord-274141-vujx538o 139 17 in in IN cord-274141-vujx538o 139 18 the the DT cord-274141-vujx538o 139 19 genera genera NNP cord-274141-vujx538o 139 20 Bupleurum Bupleurum NNP cord-274141-vujx538o 139 21 L. L. NNP cord-274141-vujx538o 139 22 , , , cord-274141-vujx538o 139 23 Heteromorpha Heteromorpha NNP cord-274141-vujx538o 139 24 Cham Cham NNP cord-274141-vujx538o 139 25 . . . cord-274141-vujx538o 139 26 & & CC cord-274141-vujx538o 139 27 Schltdl Schltdl NNP cord-274141-vujx538o 139 28 . . NNP cord-274141-vujx538o 139 29 , , , cord-274141-vujx538o 139 30 and and CC cord-274141-vujx538o 139 31 Scrophularia Scrophularia NNP cord-274141-vujx538o 139 32 L. L. NNP cord-274141-vujx538o 139 33 ( ( -LRB- cord-274141-vujx538o 139 34 Cheng Cheng NNP cord-274141-vujx538o 139 35 et et NNP cord-274141-vujx538o 139 36 al al NNP cord-274141-vujx538o 139 37 . . . cord-274141-vujx538o 139 38 2006 2006 CD cord-274141-vujx538o 139 39 ) ) -RRB- cord-274141-vujx538o 139 40 . . . cord-274141-vujx538o 140 1 Saikosaponins Saikosaponins NNP cord-274141-vujx538o 140 2 A A NNP cord-274141-vujx538o 140 3 , , , cord-274141-vujx538o 140 4 B b NN cord-274141-vujx538o 140 5 2 2 CD cord-274141-vujx538o 140 6 , , , cord-274141-vujx538o 140 7 C C NNP cord-274141-vujx538o 140 8 , , , cord-274141-vujx538o 140 9 and and CC cord-274141-vujx538o 140 10 D D NNP cord-274141-vujx538o 140 11 demonstrated demonstrate VBD cord-274141-vujx538o 140 12 anti anti JJ cord-274141-vujx538o 140 13 - - JJ cord-274141-vujx538o 140 14 HCoV-229E HCoV-229E NNP cord-274141-vujx538o 140 15 activity activity NN cord-274141-vujx538o 140 16 at at IN cord-274141-vujx538o 140 17 concentrations concentration NNS cord-274141-vujx538o 140 18 of of IN cord-274141-vujx538o 140 19 0.25 0.25 CD cord-274141-vujx538o 140 20 - - SYM cord-274141-vujx538o 140 21 25 25 CD cord-274141-vujx538o 140 22 μM μM NNP cord-274141-vujx538o 140 23 , , , cord-274141-vujx538o 140 24 with with IN cord-274141-vujx538o 140 25 the the DT cord-274141-vujx538o 140 26 strongest strong JJS cord-274141-vujx538o 140 27 activity activity NN cord-274141-vujx538o 140 28 being be VBG cord-274141-vujx538o 140 29 noted note VBN cord-274141-vujx538o 140 30 for for IN cord-274141-vujx538o 140 31 saikosaponin saikosaponin NNP cord-274141-vujx538o 140 32 B B NNP cord-274141-vujx538o 140 33 2 2 CD cord-274141-vujx538o 140 34 ( ( -LRB- cord-274141-vujx538o 140 35 4 4 CD cord-274141-vujx538o 140 36 ) ) -RRB- cord-274141-vujx538o 141 1 ( ( -LRB- cord-274141-vujx538o 141 2 IC IC NNP cord-274141-vujx538o 141 3 50 50 CD cord-274141-vujx538o 141 4 1.7 1.7 CD cord-274141-vujx538o 141 5 ± ± CD cord-274141-vujx538o 141 6 0.1 0.1 CD cord-274141-vujx538o 141 7 μM μm CD cord-274141-vujx538o 141 8 ) ) -RRB- cord-274141-vujx538o 142 1 ( ( -LRB- cord-274141-vujx538o 142 2 Cheng Cheng NNP cord-274141-vujx538o 142 3 et et NNP cord-274141-vujx538o 142 4 al al NNP cord-274141-vujx538o 142 5 . . . cord-274141-vujx538o 142 6 2006 2006 CD cord-274141-vujx538o 142 7 ) ) -RRB- cord-274141-vujx538o 142 8 . . . cord-274141-vujx538o 143 1 Since since IN cord-274141-vujx538o 143 2 saikosaponin saikosaponin NNP cord-274141-vujx538o 143 3 B B NNP cord-274141-vujx538o 143 4 2 2 CD cord-274141-vujx538o 143 5 blocks block VBZ cord-274141-vujx538o 143 6 HCoV-229E HCoV-229E NNP cord-274141-vujx538o 143 7 attachment attachment NN cord-274141-vujx538o 143 8 and and CC cord-274141-vujx538o 143 9 penetration penetration NN cord-274141-vujx538o 143 10 , , , cord-274141-vujx538o 143 11 it -PRON- PRP cord-274141-vujx538o 143 12 could could MD cord-274141-vujx538o 143 13 be be VB cord-274141-vujx538o 143 14 a a DT cord-274141-vujx538o 143 15 novel novel JJ cord-274141-vujx538o 143 16 lead lead NN cord-274141-vujx538o 143 17 for for IN cord-274141-vujx538o 143 18 the the DT cord-274141-vujx538o 143 19 development development NN cord-274141-vujx538o 143 20 of of IN cord-274141-vujx538o 143 21 a a DT cord-274141-vujx538o 143 22 potential potential JJ cord-274141-vujx538o 143 23 chemo chemo NN cord-274141-vujx538o 143 24 - - HYPH cord-274141-vujx538o 143 25 preventive preventive JJ cord-274141-vujx538o 143 26 agent agent NN cord-274141-vujx538o 143 27 for for IN cord-274141-vujx538o 143 28 SARS SARS NNP cord-274141-vujx538o 143 29 - - HYPH cord-274141-vujx538o 143 30 CoV CoV NNP cord-274141-vujx538o 143 31 infection infection NN cord-274141-vujx538o 144 1 ( ( -LRB- cord-274141-vujx538o 144 2 Cheng Cheng NNP cord-274141-vujx538o 144 3 et et NNP cord-274141-vujx538o 144 4 al al NNP cord-274141-vujx538o 144 5 . . . cord-274141-vujx538o 144 6 2006 2006 CD cord-274141-vujx538o 144 7 ) ) -RRB- cord-274141-vujx538o 144 8 . . . cord-274141-vujx538o 145 1 Yang Yang NNP cord-274141-vujx538o 145 2 et et NNP cord-274141-vujx538o 145 3 al al NNP cord-274141-vujx538o 145 4 . . . cord-274141-vujx538o 146 1 ( ( -LRB- cord-274141-vujx538o 146 2 2020 2020 CD cord-274141-vujx538o 146 3 ) ) -RRB- cord-274141-vujx538o 146 4 reported report VBD cord-274141-vujx538o 146 5 that that IN cord-274141-vujx538o 146 6 saikosaponins saikosaponin NNS cord-274141-vujx538o 146 7 and and CC cord-274141-vujx538o 146 8 glycyrrhizin glycyrrhizin NNP cord-274141-vujx538o 146 9 from from IN cord-274141-vujx538o 146 10 Toona Toona NNP cord-274141-vujx538o 146 11 sinensis sinensis NN cord-274141-vujx538o 146 12 ( ( -LRB- cord-274141-vujx538o 146 13 Juss Juss NNP cord-274141-vujx538o 146 14 . . . cord-274141-vujx538o 146 15 ) ) -RRB- cord-274141-vujx538o 147 1 M.Roem m.roem NN cord-274141-vujx538o 147 2 . . . cord-274141-vujx538o 148 1 had have VBD cord-274141-vujx538o 148 2 potent potent JJ cord-274141-vujx538o 148 3 anti anti JJ cord-274141-vujx538o 148 4 - - JJ cord-274141-vujx538o 148 5 SARS SARS NNP cord-274141-vujx538o 148 6 - - HYPH cord-274141-vujx538o 148 7 CoV cov NN cord-274141-vujx538o 148 8 effects effect NNS cord-274141-vujx538o 148 9 by by IN cord-274141-vujx538o 148 10 inhibition inhibition NN cord-274141-vujx538o 148 11 of of IN cord-274141-vujx538o 148 12 viral viral JJ cord-274141-vujx538o 148 13 cellular cellular JJ cord-274141-vujx538o 148 14 entry entry NN cord-274141-vujx538o 148 15 , , , cord-274141-vujx538o 148 16 adsorption adsorption NN cord-274141-vujx538o 148 17 , , , cord-274141-vujx538o 148 18 and and CC cord-274141-vujx538o 148 19 penetration penetration NN cord-274141-vujx538o 148 20 . . . cord-274141-vujx538o 149 1 The the DT cord-274141-vujx538o 149 2 licorice licorice NN cord-274141-vujx538o 149 3 plant plant NN cord-274141-vujx538o 149 4 , , , cord-274141-vujx538o 149 5 Glycyrrhiza Glycyrrhiza NNP cord-274141-vujx538o 149 6 glabra glabra RB cord-274141-vujx538o 149 7 L. L. NNP cord-274141-vujx538o 149 8 , , , cord-274141-vujx538o 149 9 was be VBD cord-274141-vujx538o 149 10 reported report VBN cord-274141-vujx538o 149 11 to to TO cord-274141-vujx538o 149 12 have have VB cord-274141-vujx538o 149 13 specific specific JJ cord-274141-vujx538o 149 14 anti anti JJ cord-274141-vujx538o 149 15 - - JJ cord-274141-vujx538o 149 16 SARS sars JJ cord-274141-vujx538o 149 17 effects effect NNS cord-274141-vujx538o 149 18 ( ( -LRB- cord-274141-vujx538o 149 19 Polansky Polansky NNP cord-274141-vujx538o 149 20 and and CC cord-274141-vujx538o 149 21 Lori Lori NNP cord-274141-vujx538o 149 22 2020 2020 CD cord-274141-vujx538o 149 23 ) ) -RRB- cord-274141-vujx538o 149 24 . . . cord-274141-vujx538o 150 1 Constituents constituent NNS cord-274141-vujx538o 150 2 of of IN cord-274141-vujx538o 150 3 licorice licorice NNS cord-274141-vujx538o 150 4 include include VBP cord-274141-vujx538o 150 5 triterpenoids triterpenoid NNS cord-274141-vujx538o 150 6 such such JJ cord-274141-vujx538o 150 7 as as IN cord-274141-vujx538o 150 8 glycyrrhizin glycyrrhizin NNP cord-274141-vujx538o 150 9 or or CC cord-274141-vujx538o 150 10 glycyrrhizic glycyrrhizic NNP cord-274141-vujx538o 150 11 acid acid NN cord-274141-vujx538o 150 12 ( ( -LRB- cord-274141-vujx538o 150 13 5 5 CD cord-274141-vujx538o 150 14 ) ) -RRB- cord-274141-vujx538o 150 15 . . . cord-274141-vujx538o 151 1 Glycyrrhizin Glycyrrhizin NNP cord-274141-vujx538o 151 2 ( ( -LRB- cord-274141-vujx538o 151 3 5 5 LS cord-274141-vujx538o 151 4 ) ) -RRB- cord-274141-vujx538o 151 5 exerted exert VBD cord-274141-vujx538o 151 6 very very RB cord-274141-vujx538o 151 7 high high JJ cord-274141-vujx538o 151 8 antiviral antiviral JJ cord-274141-vujx538o 151 9 activity activity NN cord-274141-vujx538o 151 10 and and CC cord-274141-vujx538o 151 11 in in IN cord-274141-vujx538o 151 12 vitro vitro FW cord-274141-vujx538o 151 13 inhibition inhibition NN cord-274141-vujx538o 151 14 of of IN cord-274141-vujx538o 151 15 SARS SARS NNP cord-274141-vujx538o 151 16 - - HYPH cord-274141-vujx538o 151 17 CoV CoV NNP cord-274141-vujx538o 151 18 ( ( -LRB- cord-274141-vujx538o 151 19 EC EC NNP cord-274141-vujx538o 151 20 50 50 CD cord-274141-vujx538o 151 21 300 300 CD cord-274141-vujx538o 151 22 μg μg NN cord-274141-vujx538o 151 23 / / SYM cord-274141-vujx538o 151 24 ml ml NN cord-274141-vujx538o 151 25 ) ) -RRB- cord-274141-vujx538o 151 26 ( ( -LRB- cord-274141-vujx538o 151 27 Cinatl Cinatl NNP cord-274141-vujx538o 151 28 et et NNP cord-274141-vujx538o 151 29 al al NNP cord-274141-vujx538o 151 30 . . NNP cord-274141-vujx538o 151 31 2003 2003 CD cord-274141-vujx538o 151 32 ) ) -RRB- cord-274141-vujx538o 151 33 . . . cord-274141-vujx538o 152 1 Glycyrrhizin Glycyrrhizin NNP cord-274141-vujx538o 152 2 and and CC cord-274141-vujx538o 152 3 its -PRON- PRP$ cord-274141-vujx538o 152 4 derivatives derivative NNS cord-274141-vujx538o 152 5 inhibited inhibit VBN cord-274141-vujx538o 152 6 SARS SARS NNP cord-274141-vujx538o 152 7 - - HYPH cord-274141-vujx538o 152 8 CoV cov NN cord-274141-vujx538o 152 9 replication replication NN cord-274141-vujx538o 152 10 in in IN cord-274141-vujx538o 152 11 vitro vitro FW cord-274141-vujx538o 152 12 ( ( -LRB- cord-274141-vujx538o 152 13 Baltina Baltina NNP cord-274141-vujx538o 152 14 et et NNP cord-274141-vujx538o 152 15 al al NNP cord-274141-vujx538o 152 16 . . NNP cord-274141-vujx538o 152 17 2015 2015 CD cord-274141-vujx538o 152 18 ) ) -RRB- cord-274141-vujx538o 152 19 . . . cord-274141-vujx538o 153 1 Ryu Ryu NNP cord-274141-vujx538o 153 2 et et FW cord-274141-vujx538o 153 3 al al NNP cord-274141-vujx538o 153 4 . . . cord-274141-vujx538o 154 1 ( ( -LRB- cord-274141-vujx538o 154 2 2010a 2010a NNS cord-274141-vujx538o 154 3 ) ) -RRB- cord-274141-vujx538o 154 4 reported report VBD cord-274141-vujx538o 154 5 that that IN cord-274141-vujx538o 154 6 95 95 CD cord-274141-vujx538o 154 7 % % NN cord-274141-vujx538o 154 8 methanolic methanolic JJ cord-274141-vujx538o 154 9 extracts extract NNS cord-274141-vujx538o 154 10 of of IN cord-274141-vujx538o 154 11 the the DT cord-274141-vujx538o 154 12 bark bark NN cord-274141-vujx538o 154 13 of of IN cord-274141-vujx538o 154 14 Tripterygium Tripterygium NNP cord-274141-vujx538o 154 15 regelii regelii NNP cord-274141-vujx538o 154 16 Sprague Sprague NNP cord-274141-vujx538o 154 17 & & CC cord-274141-vujx538o 154 18 Takeda Takeda NNP cord-274141-vujx538o 154 19 remarkably remarkably RB cord-274141-vujx538o 154 20 inhibited inhibit VBD cord-274141-vujx538o 154 21 SARS SARS NNP cord-274141-vujx538o 154 22 - - HYPH cord-274141-vujx538o 154 23 CoV CoV NNP cord-274141-vujx538o 154 24 3CL 3CL NNP cord-274141-vujx538o 154 25 pro pro JJ cord-274141-vujx538o 154 26 activity activity NN cord-274141-vujx538o 154 27 ( ( -LRB- cord-274141-vujx538o 154 28 > > NFP cord-274141-vujx538o 154 29 70 70 CD cord-274141-vujx538o 154 30 % % NN cord-274141-vujx538o 154 31 inhibition inhibition NN cord-274141-vujx538o 154 32 at at IN cord-274141-vujx538o 154 33 30 30 CD cord-274141-vujx538o 154 34 μg μg NN cord-274141-vujx538o 154 35 / / SYM cord-274141-vujx538o 154 36 ml ml NN cord-274141-vujx538o 154 37 ) ) -RRB- cord-274141-vujx538o 155 1 ( ( -LRB- cord-274141-vujx538o 155 2 Ryu Ryu NNP cord-274141-vujx538o 155 3 et et FW cord-274141-vujx538o 155 4 al al NNP cord-274141-vujx538o 155 5 . . NNP cord-274141-vujx538o 155 6 2010a 2010a CD cord-274141-vujx538o 155 7 ) ) -RRB- cord-274141-vujx538o 155 8 . . . cord-274141-vujx538o 156 1 The the DT cord-274141-vujx538o 156 2 active active JJ cord-274141-vujx538o 156 3 compounds compound NNS cord-274141-vujx538o 156 4 of of IN cord-274141-vujx538o 156 5 T. t. NN cord-274141-vujx538o 156 6 regelii regelii NN cord-274141-vujx538o 156 7 are be VBP cord-274141-vujx538o 156 8 four four CD cord-274141-vujx538o 156 9 quinone quinone NN cord-274141-vujx538o 156 10 - - HYPH cord-274141-vujx538o 156 11 methide methide JJ cord-274141-vujx538o 156 12 triterpenoid triterpenoid NNP cord-274141-vujx538o 156 13 derivatives derivative NNS cord-274141-vujx538o 156 14 : : : cord-274141-vujx538o 156 15 celastrol celastrol NNP cord-274141-vujx538o 156 16 , , , cord-274141-vujx538o 156 17 pristimerin pristimerin NNP cord-274141-vujx538o 156 18 , , , cord-274141-vujx538o 156 19 tingenone tingenone NN cord-274141-vujx538o 156 20 , , , cord-274141-vujx538o 156 21 and and CC cord-274141-vujx538o 156 22 iguesterin iguesterin NNP cord-274141-vujx538o 156 23 ( ( -LRB- cord-274141-vujx538o 156 24 6 6 CD cord-274141-vujx538o 156 25 ) ) -RRB- cord-274141-vujx538o 156 26 with with IN cord-274141-vujx538o 156 27 IC IC NNP cord-274141-vujx538o 156 28 50 50 CD cord-274141-vujx538o 156 29 values value NNS cord-274141-vujx538o 156 30 of of IN cord-274141-vujx538o 156 31 10.3 10.3 CD cord-274141-vujx538o 156 32 , , , cord-274141-vujx538o 156 33 5.5 5.5 CD cord-274141-vujx538o 156 34 , , , cord-274141-vujx538o 156 35 9.9 9.9 CD cord-274141-vujx538o 156 36 , , , cord-274141-vujx538o 156 37 and and CC cord-274141-vujx538o 156 38 2.6 2.6 CD cord-274141-vujx538o 156 39 μM μm CD cord-274141-vujx538o 156 40 , , , cord-274141-vujx538o 156 41 respectively respectively RB cord-274141-vujx538o 156 42 , , , cord-274141-vujx538o 156 43 against against IN cord-274141-vujx538o 156 44 SARS SARS NNP cord-274141-vujx538o 156 45 - - HYPH cord-274141-vujx538o 156 46 CoV CoV NNP cord-274141-vujx538o 156 47 3CL 3CL NNP cord-274141-vujx538o 156 48 pro pro JJ cord-274141-vujx538o 156 49 ( ( -LRB- cord-274141-vujx538o 156 50 Ryu Ryu NNP cord-274141-vujx538o 156 51 et et FW cord-274141-vujx538o 156 52 al al NNP cord-274141-vujx538o 156 53 . . NNP cord-274141-vujx538o 156 54 2010a 2010a CD cord-274141-vujx538o 156 55 ) ) -RRB- cord-274141-vujx538o 156 56 . . . cord-274141-vujx538o 157 1 The the DT cord-274141-vujx538o 157 2 seeds seed NNS cord-274141-vujx538o 157 3 of of IN cord-274141-vujx538o 157 4 Aesculus Aesculus NNP cord-274141-vujx538o 157 5 turbinata turbinata NN cord-274141-vujx538o 157 6 Blume Blume NNP cord-274141-vujx538o 157 7 , , , cord-274141-vujx538o 157 8 a a DT cord-274141-vujx538o 157 9 medicinal medicinal JJ cord-274141-vujx538o 157 10 plant plant NN cord-274141-vujx538o 157 11 found find VBN cord-274141-vujx538o 157 12 in in IN cord-274141-vujx538o 157 13 China China NNP cord-274141-vujx538o 157 14 , , , cord-274141-vujx538o 157 15 Japan Japan NNP cord-274141-vujx538o 157 16 , , , cord-274141-vujx538o 157 17 and and CC cord-274141-vujx538o 157 18 South South NNP cord-274141-vujx538o 157 19 Korea Korea NNP cord-274141-vujx538o 157 20 , , , cord-274141-vujx538o 157 21 contain contain VBP cord-274141-vujx538o 157 22 a a DT cord-274141-vujx538o 157 23 natural natural JJ cord-274141-vujx538o 157 24 saponins saponin NNS cord-274141-vujx538o 157 25 called call VBN cord-274141-vujx538o 157 26 escins escin NNS cord-274141-vujx538o 157 27 , , , cord-274141-vujx538o 157 28 constituents constituent NNS cord-274141-vujx538o 157 29 with with IN cord-274141-vujx538o 157 30 strong strong JJ cord-274141-vujx538o 157 31 virucidal virucidal JJ cord-274141-vujx538o 157 32 effects effect NNS cord-274141-vujx538o 157 33 against against IN cord-274141-vujx538o 157 34 SARS SARS NNP cord-274141-vujx538o 157 35 - - HYPH cord-274141-vujx538o 157 36 CoV CoV NNP cord-274141-vujx538o 157 37 ( ( -LRB- cord-274141-vujx538o 157 38 EC EC NNP cord-274141-vujx538o 157 39 50 50 CD cord-274141-vujx538o 157 40 of of IN cord-274141-vujx538o 157 41 6 6 CD cord-274141-vujx538o 158 1 μM μM NNP cord-274141-vujx538o 158 2 , , , cord-274141-vujx538o 158 3 selectivity selectivity NN cord-274141-vujx538o 158 4 index index NN cord-274141-vujx538o 158 5 value value NN cord-274141-vujx538o 158 6 of of IN cord-274141-vujx538o 158 7 2.5 2.5 CD cord-274141-vujx538o 158 8 ) ) -RRB- cord-274141-vujx538o 159 1 ( ( -LRB- cord-274141-vujx538o 159 2 Kim Kim NNP cord-274141-vujx538o 159 3 et et NNP cord-274141-vujx538o 159 4 al al NNP cord-274141-vujx538o 159 5 . . . cord-274141-vujx538o 160 1 2017b 2017b CD cord-274141-vujx538o 160 2 ; ; : cord-274141-vujx538o 160 3 Salinas Salinas NNP cord-274141-vujx538o 160 4 et et NNP cord-274141-vujx538o 160 5 al al NNP cord-274141-vujx538o 160 6 . . . cord-274141-vujx538o 160 7 2019 2019 CD cord-274141-vujx538o 160 8 ) ) -RRB- cord-274141-vujx538o 160 9 . . . cord-274141-vujx538o 161 1 Betulin Betulin NNP cord-274141-vujx538o 161 2 and and CC cord-274141-vujx538o 161 3 betulinic betulinic JJ cord-274141-vujx538o 161 4 acid acid NN cord-274141-vujx538o 161 5 , , , cord-274141-vujx538o 161 6 the the DT cord-274141-vujx538o 161 7 main main JJ cord-274141-vujx538o 161 8 antiviral antiviral JJ cord-274141-vujx538o 161 9 components component NNS cord-274141-vujx538o 161 10 of of IN cord-274141-vujx538o 161 11 the the DT cord-274141-vujx538o 161 12 Betula Betula NNP cord-274141-vujx538o 161 13 L. L. NNP cord-274141-vujx538o 161 14 plants plant NNS cord-274141-vujx538o 161 15 , , , cord-274141-vujx538o 161 16 inhibit inhibit VB cord-274141-vujx538o 161 17 HIV HIV NNP cord-274141-vujx538o 161 18 fusion fusion NN cord-274141-vujx538o 161 19 and and CC cord-274141-vujx538o 161 20 one one CD cord-274141-vujx538o 161 21 of of IN cord-274141-vujx538o 161 22 the the DT cord-274141-vujx538o 161 23 steps step NNS cord-274141-vujx538o 161 24 in in IN cord-274141-vujx538o 161 25 HIV HIV NNP cord-274141-vujx538o 161 26 maturation maturation NN cord-274141-vujx538o 161 27 ( ( -LRB- cord-274141-vujx538o 161 28 Chinsembu Chinsembu NNP cord-274141-vujx538o 161 29 2016a 2016a CD cord-274141-vujx538o 161 30 ) ) -RRB- cord-274141-vujx538o 161 31 . . . cord-274141-vujx538o 162 1 A a DT cord-274141-vujx538o 162 2 methanolic methanolic JJ cord-274141-vujx538o 162 3 extract extract NN cord-274141-vujx538o 162 4 of of IN cord-274141-vujx538o 162 5 Betula Betula NNP cord-274141-vujx538o 162 6 papyrifera papyrifera NN cord-274141-vujx538o 162 7 Marshall Marshall NNP cord-274141-vujx538o 162 8 exerted exert VBD cord-274141-vujx538o 162 9 antiviral antiviral JJ cord-274141-vujx538o 162 10 activity activity NN cord-274141-vujx538o 162 11 against against IN cord-274141-vujx538o 162 12 bovine bovine JJ cord-274141-vujx538o 162 13 coronavirus coronavirus NN cord-274141-vujx538o 162 14 ( ( -LRB- cord-274141-vujx538o 162 15 Rastogi Rastogi NNP cord-274141-vujx538o 162 16 et et FW cord-274141-vujx538o 162 17 al al NNP cord-274141-vujx538o 162 18 . . NNP cord-274141-vujx538o 162 19 2015 2015 CD cord-274141-vujx538o 162 20 ) ) -RRB- cord-274141-vujx538o 162 21 . . . cord-274141-vujx538o 163 1 Many many JJ cord-274141-vujx538o 163 2 natural natural JJ cord-274141-vujx538o 163 3 polyphenols polyphenol NNS cord-274141-vujx538o 163 4 , , , cord-274141-vujx538o 163 5 with with IN cord-274141-vujx538o 163 6 antioxidant antioxidant JJ cord-274141-vujx538o 163 7 properties property NNS cord-274141-vujx538o 163 8 , , , cord-274141-vujx538o 163 9 possess possess VBP cord-274141-vujx538o 163 10 antiviral antiviral JJ cord-274141-vujx538o 163 11 activity activity NN cord-274141-vujx538o 163 12 and and CC cord-274141-vujx538o 163 13 some some DT cord-274141-vujx538o 163 14 of of IN cord-274141-vujx538o 163 15 them -PRON- PRP cord-274141-vujx538o 163 16 , , , cord-274141-vujx538o 163 17 for for IN cord-274141-vujx538o 163 18 example example NN cord-274141-vujx538o 163 19 , , , cord-274141-vujx538o 163 20 myricetin myricetin NNP cord-274141-vujx538o 163 21 ( ( -LRB- cord-274141-vujx538o 163 22 7 7 CD cord-274141-vujx538o 163 23 ) ) -RRB- cord-274141-vujx538o 163 24 , , , cord-274141-vujx538o 163 25 an an DT cord-274141-vujx538o 163 26 inhibitor inhibitor NN cord-274141-vujx538o 163 27 of of IN cord-274141-vujx538o 163 28 coronavirus coronavirus NN cord-274141-vujx538o 163 29 helicase helicase NN cord-274141-vujx538o 163 30 nsP13 nsp13 CD cord-274141-vujx538o 163 31 ( ( -LRB- cord-274141-vujx538o 163 32 IC IC NNP cord-274141-vujx538o 163 33 50 50 CD cord-274141-vujx538o 163 34 value value NN cord-274141-vujx538o 163 35 of of IN cord-274141-vujx538o 163 36 2.71 2.71 CD cord-274141-vujx538o 163 37 μM μM NNP cord-274141-vujx538o 163 38 ) ) -RRB- cord-274141-vujx538o 163 39 , , , cord-274141-vujx538o 163 40 are be VBP cord-274141-vujx538o 163 41 already already RB cord-274141-vujx538o 163 42 being be VBG cord-274141-vujx538o 163 43 used use VBN cord-274141-vujx538o 163 44 against against IN cord-274141-vujx538o 163 45 coronaviruses coronaviruse NNS cord-274141-vujx538o 163 46 ( ( -LRB- cord-274141-vujx538o 163 47 Semwal Semwal NNP cord-274141-vujx538o 163 48 et et NNP cord-274141-vujx538o 163 49 al al NNP cord-274141-vujx538o 163 50 . . . cord-274141-vujx538o 163 51 2016 2016 CD cord-274141-vujx538o 163 52 ; ; : cord-274141-vujx538o 163 53 Yu Yu NNP cord-274141-vujx538o 163 54 et et NNP cord-274141-vujx538o 163 55 al al NNP cord-274141-vujx538o 163 56 . . NNP cord-274141-vujx538o 163 57 2012 2012 CD cord-274141-vujx538o 163 58 ) ) -RRB- cord-274141-vujx538o 163 59 . . . cord-274141-vujx538o 164 1 Naturally naturally RB cord-274141-vujx538o 164 2 occurring occur VBG cord-274141-vujx538o 164 3 flavonoids flavonoid NNS cord-274141-vujx538o 164 4 such such JJ cord-274141-vujx538o 164 5 as as IN cord-274141-vujx538o 164 6 quercetin quercetin NN cord-274141-vujx538o 164 7 , , , cord-274141-vujx538o 164 8 naringin naringin NNP cord-274141-vujx538o 164 9 , , , cord-274141-vujx538o 164 10 hesperetin hesperetin NNP cord-274141-vujx538o 164 11 , , , cord-274141-vujx538o 164 12 and and CC cord-274141-vujx538o 164 13 catechin catechin NNP cord-274141-vujx538o 164 14 , , , cord-274141-vujx538o 164 15 the the DT cord-274141-vujx538o 164 16 most most RBS cord-274141-vujx538o 164 17 abundant abundant JJ cord-274141-vujx538o 164 18 polyphenols polyphenol NNS cord-274141-vujx538o 164 19 in in IN cord-274141-vujx538o 164 20 the the DT cord-274141-vujx538o 164 21 human human JJ cord-274141-vujx538o 164 22 diet diet NN cord-274141-vujx538o 164 23 , , , cord-274141-vujx538o 164 24 are be VBP cord-274141-vujx538o 164 25 usually usually RB cord-274141-vujx538o 164 26 found find VBN cord-274141-vujx538o 164 27 in in IN cord-274141-vujx538o 164 28 fruit fruit NN cord-274141-vujx538o 164 29 and and CC cord-274141-vujx538o 164 30 vegetables vegetable NNS cord-274141-vujx538o 164 31 as as IN cord-274141-vujx538o 164 32 glycosides glycoside NNS cord-274141-vujx538o 164 33 and and CC cord-274141-vujx538o 164 34 sometimes sometimes RB cord-274141-vujx538o 164 35 as as IN cord-274141-vujx538o 164 36 acylglycosides acylglycoside NNS cord-274141-vujx538o 164 37 . . . cord-274141-vujx538o 165 1 Luteolin Luteolin NNP cord-274141-vujx538o 165 2 and and CC cord-274141-vujx538o 165 3 quercetin quercetin NN cord-274141-vujx538o 165 4 can can MD cord-274141-vujx538o 165 5 interfere interfere VB cord-274141-vujx538o 165 6 with with IN cord-274141-vujx538o 165 7 adsorption adsorption NN cord-274141-vujx538o 165 8 of of IN cord-274141-vujx538o 165 9 the the DT cord-274141-vujx538o 165 10 virus virus NN cord-274141-vujx538o 165 11 to to IN cord-274141-vujx538o 165 12 its -PRON- PRP$ cord-274141-vujx538o 165 13 host host NN cord-274141-vujx538o 165 14 cells cell NNS cord-274141-vujx538o 165 15 . . . cord-274141-vujx538o 166 1 It -PRON- PRP cord-274141-vujx538o 166 2 was be VBD cord-274141-vujx538o 166 3 hypothesized hypothesize VBN cord-274141-vujx538o 166 4 that that IN cord-274141-vujx538o 166 5 specific specific JJ cord-274141-vujx538o 166 6 flavonoids flavonoid NNS cord-274141-vujx538o 166 7 , , , cord-274141-vujx538o 166 8 such such JJ cord-274141-vujx538o 166 9 as as IN cord-274141-vujx538o 166 10 quercetin quercetin NN cord-274141-vujx538o 166 11 , , , cord-274141-vujx538o 166 12 hesperetin hesperetin NNP cord-274141-vujx538o 166 13 , , , cord-274141-vujx538o 166 14 and and CC cord-274141-vujx538o 166 15 myricetin myricetin NNP cord-274141-vujx538o 166 16 ( ( -LRB- cord-274141-vujx538o 166 17 7 7 CD cord-274141-vujx538o 166 18 ) ) -RRB- cord-274141-vujx538o 166 19 and and CC cord-274141-vujx538o 166 20 their -PRON- PRP$ cord-274141-vujx538o 166 21 glycosylated glycosylated JJ cord-274141-vujx538o 166 22 derivatives derivative NNS cord-274141-vujx538o 166 23 , , , cord-274141-vujx538o 166 24 may may MD cord-274141-vujx538o 166 25 play play VB cord-274141-vujx538o 166 26 an an DT cord-274141-vujx538o 166 27 effective effective JJ cord-274141-vujx538o 166 28 role role NN cord-274141-vujx538o 166 29 in in IN cord-274141-vujx538o 166 30 inhibiting inhibit VBG cord-274141-vujx538o 166 31 SARS SARS NNP cord-274141-vujx538o 166 32 - - HYPH cord-274141-vujx538o 166 33 CoV CoV NNP cord-274141-vujx538o 166 34 entry entry NN cord-274141-vujx538o 166 35 into into IN cord-274141-vujx538o 166 36 host host NN cord-274141-vujx538o 166 37 cells cell NNS cord-274141-vujx538o 166 38 , , , cord-274141-vujx538o 166 39 specifically specifically RB cord-274141-vujx538o 166 40 by by IN cord-274141-vujx538o 166 41 binding bind VBG cord-274141-vujx538o 166 42 with with IN cord-274141-vujx538o 166 43 high high JJ cord-274141-vujx538o 166 44 affinity affinity NN cord-274141-vujx538o 166 45 to to IN cord-274141-vujx538o 166 46 the the DT cord-274141-vujx538o 166 47 spike spike NN cord-274141-vujx538o 166 48 protein protein NN cord-274141-vujx538o 166 49 , , , cord-274141-vujx538o 166 50 helicase helicase NN cord-274141-vujx538o 166 51 , , , cord-274141-vujx538o 166 52 and and CC cord-274141-vujx538o 166 53 protease protease NN cord-274141-vujx538o 166 54 sites site NNS cord-274141-vujx538o 166 55 on on IN cord-274141-vujx538o 166 56 the the DT cord-274141-vujx538o 166 57 ACE ace NN cord-274141-vujx538o 166 58 receptor receptor NN cord-274141-vujx538o 166 59 ( ( -LRB- cord-274141-vujx538o 166 60 Ngwa Ngwa NNP cord-274141-vujx538o 166 61 et et NNP cord-274141-vujx538o 166 62 al al NNP cord-274141-vujx538o 166 63 . . NNP cord-274141-vujx538o 166 64 2020 2020 CD cord-274141-vujx538o 166 65 ) ) -RRB- cord-274141-vujx538o 166 66 , , , cord-274141-vujx538o 166 67 in in IN cord-274141-vujx538o 166 68 addition addition NN cord-274141-vujx538o 166 69 to to IN cord-274141-vujx538o 166 70 acting act VBG cord-274141-vujx538o 166 71 against against IN cord-274141-vujx538o 166 72 fatty fatty JJ cord-274141-vujx538o 166 73 acid acid NN cord-274141-vujx538o 166 74 synthase synthase NN cord-274141-vujx538o 167 1 ( ( -LRB- cord-274141-vujx538o 167 2 Wen Wen NNP cord-274141-vujx538o 167 3 et et FW cord-274141-vujx538o 167 4 al al NNP cord-274141-vujx538o 167 5 . . . cord-274141-vujx538o 168 1 , , , cord-274141-vujx538o 168 2 2011 2011 CD cord-274141-vujx538o 168 3 ) ) -RRB- cord-274141-vujx538o 168 4 . . . cord-274141-vujx538o 169 1 Extracted extract VBN cord-274141-vujx538o 169 2 from from IN cord-274141-vujx538o 169 3 TCM TCM NNP cord-274141-vujx538o 169 4 herbal herbal JJ cord-274141-vujx538o 169 5 formulae formula NNS cord-274141-vujx538o 169 6 used use VBN cord-274141-vujx538o 169 7 to to TO cord-274141-vujx538o 169 8 treat treat VB cord-274141-vujx538o 169 9 SARS SARS NNP cord-274141-vujx538o 169 10 , , , cord-274141-vujx538o 169 11 the the DT cord-274141-vujx538o 169 12 following follow VBG cord-274141-vujx538o 169 13 active active JJ cord-274141-vujx538o 169 14 polyphenols polyphenol NNS cord-274141-vujx538o 169 15 inhibited inhibit VBD cord-274141-vujx538o 169 16 various various JJ cord-274141-vujx538o 169 17 steps step NNS cord-274141-vujx538o 169 18 during during IN cord-274141-vujx538o 169 19 SARS SARS NNP cord-274141-vujx538o 169 20 - - HYPH cord-274141-vujx538o 169 21 CoV CoV NNP cord-274141-vujx538o 169 22 entry entry NN cord-274141-vujx538o 169 23 and and CC cord-274141-vujx538o 169 24 replication replication NN cord-274141-vujx538o 169 25 : : : cord-274141-vujx538o 169 26 baicalin baicalin NNP cord-274141-vujx538o 169 27 , , , cord-274141-vujx538o 169 28 emodin emodin NNP cord-274141-vujx538o 169 29 , , , cord-274141-vujx538o 169 30 epigallocatechin epigallocatechin NNP cord-274141-vujx538o 169 31 , , , cord-274141-vujx538o 169 32 gallate gallate NN cord-274141-vujx538o 169 33 , , , cord-274141-vujx538o 169 34 gallocatechin gallocatechin NNP cord-274141-vujx538o 169 35 gallate gallate NNP cord-274141-vujx538o 169 36 , , , cord-274141-vujx538o 169 37 herbacetin herbacetin NNP cord-274141-vujx538o 169 38 , , , cord-274141-vujx538o 169 39 isobavaschalcone isobavaschalcone NN cord-274141-vujx538o 169 40 , , , cord-274141-vujx538o 169 41 kaempferol kaempferol NNP cord-274141-vujx538o 169 42 derivatives derivative NNS cord-274141-vujx538o 169 43 , , , cord-274141-vujx538o 169 44 luteolin luteolin NNP cord-274141-vujx538o 169 45 , , , cord-274141-vujx538o 169 46 myricetin myricetin NNP cord-274141-vujx538o 169 47 , , , cord-274141-vujx538o 169 48 quercetin quercetin NN cord-274141-vujx538o 169 49 , , , cord-274141-vujx538o 169 50 3-β 3-β CD cord-274141-vujx538o 169 51 - - HYPH cord-274141-vujx538o 169 52 D d NN cord-274141-vujx538o 169 53 - - HYPH cord-274141-vujx538o 169 54 glucoside glucoside NN cord-274141-vujx538o 169 55 , , , cord-274141-vujx538o 169 56 rhoifolin rhoifolin NNP cord-274141-vujx538o 169 57 , , , cord-274141-vujx538o 169 58 pectolinarin pectolinarin NNP cord-274141-vujx538o 169 59 , , , cord-274141-vujx538o 169 60 scutellarein scutellarein NNP cord-274141-vujx538o 169 61 , , , cord-274141-vujx538o 169 62 and and CC cord-274141-vujx538o 169 63 tetra tetra NN cord-274141-vujx538o 169 64 - - HYPH cord-274141-vujx538o 169 65 O o NN cord-274141-vujx538o 169 66 - - HYPH cord-274141-vujx538o 169 67 galloyl galloyl NN cord-274141-vujx538o 169 68 - - HYPH cord-274141-vujx538o 169 69 β β NN cord-274141-vujx538o 169 70 - - HYPH cord-274141-vujx538o 169 71 D d NN cord-274141-vujx538o 169 72 - - HYPH cord-274141-vujx538o 169 73 glucose glucose NN cord-274141-vujx538o 169 74 ) ) -RRB- cord-274141-vujx538o 169 75 . . . cord-274141-vujx538o 170 1 Quercetin Quercetin NNP cord-274141-vujx538o 170 2 ( ( -LRB- cord-274141-vujx538o 170 3 8) 8) NNP cord-274141-vujx538o 170 4 is be VBZ cord-274141-vujx538o 170 5 an an DT cord-274141-vujx538o 170 6 aglycone aglycone JJ cord-274141-vujx538o 170 7 present present NN cord-274141-vujx538o 170 8 at at IN cord-274141-vujx538o 170 9 high high JJ cord-274141-vujx538o 170 10 concentration concentration NN cord-274141-vujx538o 170 11 in in IN cord-274141-vujx538o 170 12 onions onion NNS cord-274141-vujx538o 170 13 . . . cord-274141-vujx538o 171 1 This this DT cord-274141-vujx538o 171 2 compound compound NN cord-274141-vujx538o 171 3 has have VBZ cord-274141-vujx538o 171 4 virucidal virucidal JJ cord-274141-vujx538o 171 5 activity activity NN cord-274141-vujx538o 171 6 against against IN cord-274141-vujx538o 171 7 enveloped envelop VBN cord-274141-vujx538o 171 8 viruses virus NNS cord-274141-vujx538o 171 9 such such JJ cord-274141-vujx538o 171 10 as as IN cord-274141-vujx538o 171 11 mengovirus mengovirus NNP cord-274141-vujx538o 171 12 , , , cord-274141-vujx538o 171 13 herpes herpes NNP cord-274141-vujx538o 171 14 simplex simplex NNP cord-274141-vujx538o 171 15 , , , cord-274141-vujx538o 171 16 parainfluenza parainfluenza NNP cord-274141-vujx538o 171 17 type type NNP cord-274141-vujx538o 171 18 3 3 CD cord-274141-vujx538o 171 19 , , , cord-274141-vujx538o 171 20 pseudorabies pseudorabies NN cord-274141-vujx538o 171 21 , , , cord-274141-vujx538o 171 22 respiratory respiratory JJ cord-274141-vujx538o 171 23 syncytial syncytial NN cord-274141-vujx538o 171 24 , , , cord-274141-vujx538o 171 25 and and CC cord-274141-vujx538o 171 26 Sindbis Sindbis NNP cord-274141-vujx538o 171 27 viruses virus NNS cord-274141-vujx538o 171 28 ) ) -RRB- cord-274141-vujx538o 171 29 . . . cord-274141-vujx538o 172 1 Quercetin quercetin NN cord-274141-vujx538o 172 2 is be VBZ cord-274141-vujx538o 172 3 able able JJ cord-274141-vujx538o 172 4 to to TO cord-274141-vujx538o 172 5 inhibit inhibit VB cord-274141-vujx538o 172 6 H h NN cord-274141-vujx538o 173 1 + + CC cord-274141-vujx538o 173 2 -ATPase -atpase NN cord-274141-vujx538o 173 3 of of IN cord-274141-vujx538o 173 4 lysosomal lysosomal JJ cord-274141-vujx538o 173 5 membrane membrane NN cord-274141-vujx538o 174 1 and and CC cord-274141-vujx538o 174 2 thus thus RB cord-274141-vujx538o 174 3 prevents prevent VBZ cord-274141-vujx538o 174 4 virus virus NN cord-274141-vujx538o 174 5 coat coat NN cord-274141-vujx538o 174 6 removal removal NN cord-274141-vujx538o 174 7 and and CC cord-274141-vujx538o 174 8 blocks block VBZ cord-274141-vujx538o 174 9 viral viral JJ cord-274141-vujx538o 174 10 replication replication NN cord-274141-vujx538o 174 11 and and CC cord-274141-vujx538o 174 12 competitively competitively RB cord-274141-vujx538o 174 13 inhibits inhibit VBZ cord-274141-vujx538o 174 14 SARS SARS NNP cord-274141-vujx538o 174 15 - - HYPH cord-274141-vujx538o 174 16 CoV CoV NNP cord-274141-vujx538o 174 17 3CL 3CL NNP cord-274141-vujx538o 174 18 pro pro JJ cord-274141-vujx538o 174 19 with with IN cord-274141-vujx538o 174 20 IC IC NNP cord-274141-vujx538o 174 21 50 50 CD cord-274141-vujx538o 174 22 of of IN cord-274141-vujx538o 174 23 42.79 42.79 CD cord-274141-vujx538o 174 24 ± ± CD cord-274141-vujx538o 174 25 4.97 4.97 CD cord-274141-vujx538o 175 1 μM μM NNP cord-274141-vujx538o 176 1 ( ( -LRB- cord-274141-vujx538o 176 2 Chen Chen NNP cord-274141-vujx538o 176 3 et et NNP cord-274141-vujx538o 176 4 al al NNP cord-274141-vujx538o 176 5 . . . cord-274141-vujx538o 176 6 2006 2006 CD cord-274141-vujx538o 176 7 ) ) -RRB- cord-274141-vujx538o 176 8 . . . cord-274141-vujx538o 177 1 Torreya Torreya NNP cord-274141-vujx538o 177 2 nucifera nucifera JJ cord-274141-vujx538o 177 3 ( ( -LRB- cord-274141-vujx538o 177 4 L. L. NNP cord-274141-vujx538o 177 5 ) ) -RRB- cord-274141-vujx538o 177 6 Siebold Siebold NNP cord-274141-vujx538o 177 7 & & CC cord-274141-vujx538o 177 8 Zucc Zucc NNP cord-274141-vujx538o 177 9 . . . cord-274141-vujx538o 178 1 is be VBZ cord-274141-vujx538o 178 2 a a DT cord-274141-vujx538o 178 3 traditional traditional JJ cord-274141-vujx538o 178 4 medicinal medicinal JJ cord-274141-vujx538o 178 5 plant plant NN cord-274141-vujx538o 178 6 in in IN cord-274141-vujx538o 178 7 Asia Asia NNP cord-274141-vujx538o 178 8 . . . cord-274141-vujx538o 179 1 The the DT cord-274141-vujx538o 179 2 ethanol ethanol NN cord-274141-vujx538o 179 3 leaf leaf NN cord-274141-vujx538o 179 4 extract extract NN cord-274141-vujx538o 179 5 of of IN cord-274141-vujx538o 179 6 T. T. NNP cord-274141-vujx538o 179 7 nucifera nucifera NNP cord-274141-vujx538o 179 8 exerts exert VBZ cord-274141-vujx538o 179 9 good good JJ cord-274141-vujx538o 179 10 SARS SARS NNP cord-274141-vujx538o 179 11 - - HYPH cord-274141-vujx538o 179 12 CoV CoV NNP cord-274141-vujx538o 179 13 3CL 3CL NNP cord-274141-vujx538o 179 14 pro pro JJ cord-274141-vujx538o 179 15 inhibitory inhibitory JJ cord-274141-vujx538o 179 16 activity activity NN cord-274141-vujx538o 179 17 ( ( -LRB- cord-274141-vujx538o 179 18 62 62 CD cord-274141-vujx538o 179 19 % % NN cord-274141-vujx538o 179 20 at at IN cord-274141-vujx538o 179 21 100 100 CD cord-274141-vujx538o 179 22 μg μg NN cord-274141-vujx538o 179 23 / / SYM cord-274141-vujx538o 179 24 ml ml NN cord-274141-vujx538o 179 25 ) ) -RRB- cord-274141-vujx538o 180 1 ( ( -LRB- cord-274141-vujx538o 180 2 Ryu Ryu NNP cord-274141-vujx538o 180 3 et et FW cord-274141-vujx538o 180 4 al al NNP cord-274141-vujx538o 180 5 . . NNP cord-274141-vujx538o 180 6 2010b 2010b CD cord-274141-vujx538o 180 7 ) ) -RRB- cord-274141-vujx538o 180 8 . . . cord-274141-vujx538o 181 1 Following follow VBG cord-274141-vujx538o 181 2 the the DT cord-274141-vujx538o 181 3 bioactivityguided bioactivityguided JJ cord-274141-vujx538o 181 4 fractionation fractionation NN cord-274141-vujx538o 181 5 of of IN cord-274141-vujx538o 181 6 T. t. NN cord-274141-vujx538o 181 7 nucifera nucifera NNP cord-274141-vujx538o 181 8 , , , cord-274141-vujx538o 181 9 the the DT cord-274141-vujx538o 181 10 biflavone biflavone NNP cord-274141-vujx538o 181 11 amentoflavone amentoflavone NNP cord-274141-vujx538o 181 12 ( ( -LRB- cord-274141-vujx538o 181 13 9 9 CD cord-274141-vujx538o 181 14 ) ) -RRB- cord-274141-vujx538o 181 15 showed show VBD cord-274141-vujx538o 181 16 the the DT cord-274141-vujx538o 181 17 most most RBS cord-274141-vujx538o 181 18 potent potent JJ cord-274141-vujx538o 181 19 SARS SARS NNP cord-274141-vujx538o 181 20 - - HYPH cord-274141-vujx538o 181 21 CoV CoV NNP cord-274141-vujx538o 181 22 3CL 3CL NNP cord-274141-vujx538o 181 23 pro pro JJ cord-274141-vujx538o 181 24 inhibitory inhibitory JJ cord-274141-vujx538o 181 25 effect effect NN cord-274141-vujx538o 181 26 with with IN cord-274141-vujx538o 181 27 IC IC NNP cord-274141-vujx538o 181 28 50 50 CD cord-274141-vujx538o 181 29 of of IN cord-274141-vujx538o 181 30 8.3 8.3 CD cord-274141-vujx538o 181 31 μM μm CD cord-274141-vujx538o 182 1 ( ( -LRB- cord-274141-vujx538o 182 2 Ryu Ryu NNP cord-274141-vujx538o 182 3 et et FW cord-274141-vujx538o 182 4 al al NNP cord-274141-vujx538o 182 5 . . NNP cord-274141-vujx538o 182 6 2010b 2010b CD cord-274141-vujx538o 182 7 ) ) -RRB- cord-274141-vujx538o 182 8 . . . cord-274141-vujx538o 183 1 Apigenin Apigenin NNP cord-274141-vujx538o 183 2 , , , cord-274141-vujx538o 183 3 luteolin luteolin NN cord-274141-vujx538o 183 4 , , , cord-274141-vujx538o 183 5 and and CC cord-274141-vujx538o 183 6 quercetin quercetin JJ cord-274141-vujx538o 183 7 inhibited inhibit VBN cord-274141-vujx538o 183 8 SARS SARS NNP cord-274141-vujx538o 183 9 - - HYPH cord-274141-vujx538o 183 10 CoV CoV NNP cord-274141-vujx538o 183 11 3CL 3CL NNP cord-274141-vujx538o 183 12 pro pro JJ cord-274141-vujx538o 183 13 activity activity NN cord-274141-vujx538o 183 14 with with IN cord-274141-vujx538o 183 15 IC IC NNP cord-274141-vujx538o 183 16 50 50 CD cord-274141-vujx538o 183 17 values value NNS cord-274141-vujx538o 183 18 of of IN cord-274141-vujx538o 183 19 280.8 280.8 CD cord-274141-vujx538o 183 20 , , , cord-274141-vujx538o 183 21 20.2 20.2 CD cord-274141-vujx538o 183 22 , , , cord-274141-vujx538o 183 23 and and CC cord-274141-vujx538o 183 24 23.8 23.8 CD cord-274141-vujx538o 183 25 μM μm CD cord-274141-vujx538o 183 26 , , , cord-274141-vujx538o 183 27 respectively respectively RB cord-274141-vujx538o 183 28 ( ( -LRB- cord-274141-vujx538o 183 29 Ryu Ryu NNP cord-274141-vujx538o 183 30 et et FW cord-274141-vujx538o 183 31 al al NNP cord-274141-vujx538o 183 32 . . NNP cord-274141-vujx538o 183 33 2010b 2010b CD cord-274141-vujx538o 183 34 ) ) -RRB- cord-274141-vujx538o 183 35 . . . cord-274141-vujx538o 184 1 Zhong Zhong NNP cord-274141-vujx538o 184 2 et et NNP cord-274141-vujx538o 184 3 al al NNP cord-274141-vujx538o 184 4 . . . cord-274141-vujx538o 185 1 ( ( -LRB- cord-274141-vujx538o 185 2 2013 2013 CD cord-274141-vujx538o 185 3 ) ) -RRB- cord-274141-vujx538o 185 4 found find VBD cord-274141-vujx538o 185 5 that that IN cord-274141-vujx538o 185 6 Jinchai Jinchai NNP cord-274141-vujx538o 185 7 , , , cord-274141-vujx538o 185 8 a a DT cord-274141-vujx538o 185 9 capsule capsule NN cord-274141-vujx538o 185 10 of of IN cord-274141-vujx538o 185 11 TCM TCM NNP cord-274141-vujx538o 185 12 consisting consist VBG cord-274141-vujx538o 185 13 of of IN cord-274141-vujx538o 185 14 plants plant NNS cord-274141-vujx538o 185 15 such such JJ cord-274141-vujx538o 185 16 as as IN cord-274141-vujx538o 185 17 Lonicera Lonicera NNP cord-274141-vujx538o 185 18 japonica japonica NN cord-274141-vujx538o 185 19 Thunb Thunb NNP cord-274141-vujx538o 185 20 . . NNP cord-274141-vujx538o 185 21 , , , cord-274141-vujx538o 185 22 Bupleurum Bupleurum NNP cord-274141-vujx538o 185 23 chinense chinense NN cord-274141-vujx538o 185 24 DC DC NNP cord-274141-vujx538o 185 25 . . NNP cord-274141-vujx538o 185 26 , , , cord-274141-vujx538o 185 27 Astragalus Astragalus NNP cord-274141-vujx538o 185 28 membranaceus membranaceus NN cord-274141-vujx538o 185 29 ( ( -LRB- cord-274141-vujx538o 185 30 Fisch Fisch NNP cord-274141-vujx538o 185 31 . . . cord-274141-vujx538o 185 32 ) ) -RRB- cord-274141-vujx538o 186 1 Bunge Bunge NNP cord-274141-vujx538o 186 2 , , , cord-274141-vujx538o 186 3 and and CC cord-274141-vujx538o 186 4 Codonopsis Codonopsis NNP cord-274141-vujx538o 186 5 pilosula pilosula NN cord-274141-vujx538o 186 6 subsp subsp NN cord-274141-vujx538o 186 7 . . . cord-274141-vujx538o 187 1 tangshen tangshen NNP cord-274141-vujx538o 187 2 ( ( -LRB- cord-274141-vujx538o 187 3 Oliv Oliv NNP cord-274141-vujx538o 187 4 . . . cord-274141-vujx538o 187 5 ) ) -RRB- cord-274141-vujx538o 188 1 D.Y.Hong d.y.hong JJ cord-274141-vujx538o 188 2 inhibited inhibit VBN cord-274141-vujx538o 188 3 SARS SARS NNP cord-274141-vujx538o 188 4 - - HYPH cord-274141-vujx538o 188 5 CoV. CoV. NNP cord-274141-vujx538o 188 6 Jinchai Jinchai NNP cord-274141-vujx538o 188 7 blocks block VBZ cord-274141-vujx538o 188 8 SARS SARS NNP cord-274141-vujx538o 188 9 - - HYPH cord-274141-vujx538o 188 10 CoV cov NN cord-274141-vujx538o 188 11 infection infection NN cord-274141-vujx538o 188 12 by by IN cord-274141-vujx538o 188 13 weakening weaken VBG cord-274141-vujx538o 188 14 adsorption adsorption NN cord-274141-vujx538o 188 15 of of IN cord-274141-vujx538o 188 16 viruses virus NNS cord-274141-vujx538o 188 17 to to IN cord-274141-vujx538o 188 18 cells cell NNS cord-274141-vujx538o 188 19 and and CC cord-274141-vujx538o 188 20 reduces reduce VBZ cord-274141-vujx538o 188 21 the the DT cord-274141-vujx538o 188 22 ability ability NN cord-274141-vujx538o 188 23 of of IN cord-274141-vujx538o 188 24 SARS SARS NNP cord-274141-vujx538o 188 25 - - HYPH cord-274141-vujx538o 188 26 CoV CoV NNP cord-274141-vujx538o 188 27 to to TO cord-274141-vujx538o 188 28 infect infect VB cord-274141-vujx538o 188 29 surrounding surround VBG cord-274141-vujx538o 188 30 tissues tissue NNS cord-274141-vujx538o 188 31 ( ( -LRB- cord-274141-vujx538o 188 32 Zhong Zhong NNP cord-274141-vujx538o 188 33 et et FW cord-274141-vujx538o 188 34 al al NNP cord-274141-vujx538o 188 35 . . NNP cord-274141-vujx538o 188 36 2013 2013 CD cord-274141-vujx538o 188 37 ) ) -RRB- cord-274141-vujx538o 188 38 . . . cord-274141-vujx538o 189 1 The the DT cord-274141-vujx538o 189 2 main main JJ cord-274141-vujx538o 189 3 active active JJ cord-274141-vujx538o 189 4 constituents constituent NNS cord-274141-vujx538o 189 5 of of IN cord-274141-vujx538o 189 6 Jinchai Jinchai NNP cord-274141-vujx538o 189 7 are be VBP cord-274141-vujx538o 189 8 chlorogenic chlorogenic JJ cord-274141-vujx538o 189 9 acid acid NN cord-274141-vujx538o 189 10 and and CC cord-274141-vujx538o 189 11 baicalin baicalin NNP cord-274141-vujx538o 189 12 ( ( -LRB- cord-274141-vujx538o 189 13 10 10 CD cord-274141-vujx538o 189 14 ) ) -RRB- cord-274141-vujx538o 189 15 whose whose WP$ cord-274141-vujx538o 189 16 EC EC NNP cord-274141-vujx538o 189 17 50 50 CD cord-274141-vujx538o 189 18 ( ( -LRB- cord-274141-vujx538o 189 19 μg μg NNP cord-274141-vujx538o 189 20 / / SYM cord-274141-vujx538o 189 21 ml ml NN cord-274141-vujx538o 189 22 ) ) -RRB- cord-274141-vujx538o 189 23 at at IN cord-274141-vujx538o 189 24 48 48 CD cord-274141-vujx538o 189 25 h h NN cord-274141-vujx538o 189 26 was be VBD cord-274141-vujx538o 189 27 12.5 12.5 CD cord-274141-vujx538o 189 28 to to IN cord-274141-vujx538o 189 29 25 25 CD cord-274141-vujx538o 189 30 , , , cord-274141-vujx538o 189 31 EC EC NNP cord-274141-vujx538o 189 32 50 50 CD cord-274141-vujx538o 189 33 ( ( -LRB- cord-274141-vujx538o 189 34 μg μg NNP cord-274141-vujx538o 189 35 / / SYM cord-274141-vujx538o 189 36 ml ml NN cord-274141-vujx538o 189 37 ) ) -RRB- cord-274141-vujx538o 189 38 at at IN cord-274141-vujx538o 189 39 72 72 CD cord-274141-vujx538o 189 40 h h NN cord-274141-vujx538o 190 1 was be VBD cord-274141-vujx538o 190 2 25 25 CD cord-274141-vujx538o 190 3 to to TO cord-274141-vujx538o 190 4 50 50 CD cord-274141-vujx538o 191 1 , , , cord-274141-vujx538o 191 2 CC CC NNP cord-274141-vujx538o 191 3 50 50 CD cord-274141-vujx538o 191 4 ( ( -LRB- cord-274141-vujx538o 191 5 μg μg NNP cord-274141-vujx538o 191 6 / / SYM cord-274141-vujx538o 191 7 ml ml NNP cord-274141-vujx538o 191 8 ) ) -RRB- cord-274141-vujx538o 191 9 was be VBD cord-274141-vujx538o 191 10 > > XX cord-274141-vujx538o 191 11 100 100 CD cord-274141-vujx538o 191 12 , , , cord-274141-vujx538o 191 13 and and CC cord-274141-vujx538o 191 14 SI SI NNP cord-274141-vujx538o 191 15 calculated calculate VBN cord-274141-vujx538o 191 16 as as IN cord-274141-vujx538o 191 17 CC CC NNP cord-274141-vujx538o 191 18 50 50 CD cord-274141-vujx538o 191 19 /EC /EC . cord-274141-vujx538o 192 1 50 50 CD cord-274141-vujx538o 192 2 at at IN cord-274141-vujx538o 192 3 48 48 CD cord-274141-vujx538o 192 4 h h NN cord-274141-vujx538o 192 5 was be VBD cord-274141-vujx538o 192 6 > > XX cord-274141-vujx538o 192 7 4 4 CD cord-274141-vujx538o 192 8 to to TO cord-274141-vujx538o 192 9 8 8 CD cord-274141-vujx538o 192 10 . . . cord-274141-vujx538o 193 1 Camellia camellia NN cord-274141-vujx538o 193 2 sinensis sinensis NN cord-274141-vujx538o 193 3 ( ( -LRB- cord-274141-vujx538o 193 4 L. L. NNP cord-274141-vujx538o 193 5 ) ) -RRB- cord-274141-vujx538o 193 6 Kuntze Kuntze NNP cord-274141-vujx538o 193 7 ( ( -LRB- cord-274141-vujx538o 193 8 black black JJ cord-274141-vujx538o 193 9 tea tea NN cord-274141-vujx538o 193 10 ) ) -RRB- cord-274141-vujx538o 194 1 polyphenol polyphenol NNP cord-274141-vujx538o 194 2 epigallocatechin epigallocatechin NNP cord-274141-vujx538o 194 3 gallate gallate NNP cord-274141-vujx538o 195 1 ( ( -LRB- cord-274141-vujx538o 195 2 EGCG EGCG NNP cord-274141-vujx538o 195 3 ) ) -RRB- cord-274141-vujx538o 195 4 inhibited inhibit VBN cord-274141-vujx538o 195 5 bovine bovine JJ cord-274141-vujx538o 195 6 coronavirus coronavirus NN cord-274141-vujx538o 195 7 propagation propagation NN cord-274141-vujx538o 196 1 ; ; : cord-274141-vujx538o 196 2 EGCG EGCG NNP cord-274141-vujx538o 196 3 interfered interfere VBD cord-274141-vujx538o 196 4 with with IN cord-274141-vujx538o 196 5 the the DT cord-274141-vujx538o 196 6 adsorption adsorption NN cord-274141-vujx538o 196 7 of of IN cord-274141-vujx538o 196 8 bovine bovine JJ cord-274141-vujx538o 196 9 coronavirus coronavirus NN cord-274141-vujx538o 196 10 to to IN cord-274141-vujx538o 196 11 Madin Madin NNP cord-274141-vujx538o 196 12 - - HYPH cord-274141-vujx538o 196 13 Darby Darby NNP cord-274141-vujx538o 196 14 bovine bovine JJ cord-274141-vujx538o 196 15 kidney kidney NN cord-274141-vujx538o 196 16 cells cell NNS cord-274141-vujx538o 197 1 ( ( -LRB- cord-274141-vujx538o 197 2 Bansal Bansal NNP cord-274141-vujx538o 197 3 et et NNP cord-274141-vujx538o 197 4 al al NNP cord-274141-vujx538o 197 5 . . NNP cord-274141-vujx538o 197 6 2013 2013 CD cord-274141-vujx538o 197 7 ) ) -RRB- cord-274141-vujx538o 197 8 . . . cord-274141-vujx538o 198 1 Although although IN cord-274141-vujx538o 198 2 Sanguisorba Sanguisorba NNP cord-274141-vujx538o 198 3 officinalis officinalis NN cord-274141-vujx538o 198 4 L. L. NNP cord-274141-vujx538o 198 5 extract extract NN cord-274141-vujx538o 198 6 inhibits inhibit VBZ cord-274141-vujx538o 198 7 HIV-1 HIV-1 NNP cord-274141-vujx538o 198 8 infection infection NN cord-274141-vujx538o 198 9 by by IN cord-274141-vujx538o 198 10 binding bind VBG cord-274141-vujx538o 198 11 to to IN cord-274141-vujx538o 198 12 the the DT cord-274141-vujx538o 198 13 viral viral JJ cord-274141-vujx538o 198 14 envelope envelope NN cord-274141-vujx538o 198 15 and and CC cord-274141-vujx538o 198 16 blocking block VBG cord-274141-vujx538o 198 17 entry entry NN cord-274141-vujx538o 198 18 of of IN cord-274141-vujx538o 198 19 the the DT cord-274141-vujx538o 198 20 virus virus NN cord-274141-vujx538o 198 21 , , , cord-274141-vujx538o 198 22 it -PRON- PRP cord-274141-vujx538o 198 23 did do VBD cord-274141-vujx538o 198 24 not not RB cord-274141-vujx538o 198 25 inhibit inhibit VB cord-274141-vujx538o 198 26 SARS SARS NNP cord-274141-vujx538o 198 27 - - HYPH cord-274141-vujx538o 198 28 CoV CoV NNP cord-274141-vujx538o 198 29 entry entry NN cord-274141-vujx538o 199 1 ( ( -LRB- cord-274141-vujx538o 199 2 Liang Liang NNP cord-274141-vujx538o 199 3 et et NNP cord-274141-vujx538o 199 4 al al NNP cord-274141-vujx538o 199 5 . . NNP cord-274141-vujx538o 199 6 2013 2013 CD cord-274141-vujx538o 199 7 ) ) -RRB- cord-274141-vujx538o 199 8 . . . cord-274141-vujx538o 200 1 In in IN cord-274141-vujx538o 200 2 oriental oriental JJ cord-274141-vujx538o 200 3 herbal herbal JJ cord-274141-vujx538o 200 4 medicine medicine NN cord-274141-vujx538o 200 5 , , , cord-274141-vujx538o 200 6 the the DT cord-274141-vujx538o 200 7 bark bark NN cord-274141-vujx538o 200 8 of of IN cord-274141-vujx538o 200 9 cinnamon cinnamon NN cord-274141-vujx538o 200 10 plant plant NN cord-274141-vujx538o 200 11 Cinnamomum Cinnamomum NNP cord-274141-vujx538o 200 12 cassia cassia NN cord-274141-vujx538o 201 1 ( ( -LRB- cord-274141-vujx538o 201 2 L. L. NNP cord-274141-vujx538o 201 3 ) ) -RRB- cord-274141-vujx538o 201 4 J. J. NNP cord-274141-vujx538o 201 5 Presl Presl NNP cord-274141-vujx538o 201 6 has have VBZ cord-274141-vujx538o 201 7 been be VBN cord-274141-vujx538o 201 8 used use VBN cord-274141-vujx538o 201 9 as as IN cord-274141-vujx538o 201 10 a a DT cord-274141-vujx538o 201 11 spice spice NN cord-274141-vujx538o 201 12 , , , cord-274141-vujx538o 201 13 infusion infusion NN cord-274141-vujx538o 201 14 , , , cord-274141-vujx538o 201 15 and and CC cord-274141-vujx538o 201 16 prime prime JJ cord-274141-vujx538o 201 17 component component NN cord-274141-vujx538o 201 18 of of IN cord-274141-vujx538o 201 19 herbal herbal JJ cord-274141-vujx538o 201 20 remedies remedy NNS cord-274141-vujx538o 201 21 for for IN cord-274141-vujx538o 201 22 common common JJ cord-274141-vujx538o 201 23 cold cold JJ cord-274141-vujx538o 201 24 , , , cord-274141-vujx538o 201 25 gastrointestinal gastrointestinal JJ cord-274141-vujx538o 201 26 infections infection NNS cord-274141-vujx538o 201 27 , , , cord-274141-vujx538o 201 28 cancer cancer NN cord-274141-vujx538o 201 29 , , , cord-274141-vujx538o 201 30 chronic chronic JJ cord-274141-vujx538o 201 31 cardiovascular cardiovascular JJ cord-274141-vujx538o 201 32 disease disease NN cord-274141-vujx538o 201 33 , , , cord-274141-vujx538o 201 34 and and CC cord-274141-vujx538o 201 35 gynecological gynecological JJ cord-274141-vujx538o 201 36 disorders disorder NNS cord-274141-vujx538o 201 37 . . . cord-274141-vujx538o 202 1 Zhuang Zhuang NNP cord-274141-vujx538o 202 2 et et NNP cord-274141-vujx538o 202 3 al al NNP cord-274141-vujx538o 202 4 . . . cord-274141-vujx538o 203 1 ( ( -LRB- cord-274141-vujx538o 203 2 2009 2009 CD cord-274141-vujx538o 203 3 ) ) -RRB- cord-274141-vujx538o 203 4 found find VBD cord-274141-vujx538o 203 5 that that IN cord-274141-vujx538o 203 6 cinnamon cinnamon NN cord-274141-vujx538o 203 7 bark bark NN cord-274141-vujx538o 203 8 extract extract NN cord-274141-vujx538o 203 9 has have VBZ cord-274141-vujx538o 203 10 anti anti JJ cord-274141-vujx538o 203 11 - - JJ cord-274141-vujx538o 203 12 RNA rna JJ cord-274141-vujx538o 203 13 viral viral JJ cord-274141-vujx538o 203 14 effects effect NNS cord-274141-vujx538o 203 15 . . . cord-274141-vujx538o 204 1 The the DT cord-274141-vujx538o 204 2 cinnamon cinnamon NN cord-274141-vujx538o 204 3 extract extract NN cord-274141-vujx538o 204 4 inhibited inhibit VBD cord-274141-vujx538o 204 5 wild wild JJ cord-274141-vujx538o 204 6 - - HYPH cord-274141-vujx538o 204 7 type type NN cord-274141-vujx538o 204 8 SARS SARS NNP cord-274141-vujx538o 204 9 - - HYPH cord-274141-vujx538o 204 10 CoV cov NN cord-274141-vujx538o 204 11 infection infection NN cord-274141-vujx538o 204 12 in in IN cord-274141-vujx538o 204 13 vitro vitro FW cord-274141-vujx538o 204 14 with with IN cord-274141-vujx538o 204 15 an an DT cord-274141-vujx538o 204 16 IC IC NNP cord-274141-vujx538o 204 17 50 50 CD cord-274141-vujx538o 204 18 of of IN cord-274141-vujx538o 204 19 43 43 CD cord-274141-vujx538o 204 20 μM μm CD cord-274141-vujx538o 204 21 ; ; : cord-274141-vujx538o 204 22 and and CC cord-274141-vujx538o 204 23 the the DT cord-274141-vujx538o 204 24 proposed propose VBN cord-274141-vujx538o 204 25 mechanism mechanism NN cord-274141-vujx538o 204 26 of of IN cord-274141-vujx538o 204 27 action action NN cord-274141-vujx538o 204 28 for for IN cord-274141-vujx538o 204 29 cinnamon cinnamon NN cord-274141-vujx538o 204 30 bark bark NN cord-274141-vujx538o 204 31 extract extract NN cord-274141-vujx538o 204 32 was be VBD cord-274141-vujx538o 204 33 blocking block VBG cord-274141-vujx538o 204 34 cell cell NN cord-274141-vujx538o 204 35 entry entry NN cord-274141-vujx538o 204 36 via via IN cord-274141-vujx538o 204 37 endocytosis endocytosis NN cord-274141-vujx538o 204 38 ( ( -LRB- cord-274141-vujx538o 204 39 Polansky Polansky NNP cord-274141-vujx538o 204 40 and and CC cord-274141-vujx538o 204 41 Lori Lori NNP cord-274141-vujx538o 204 42 2020 2020 CD cord-274141-vujx538o 204 43 ) ) -RRB- cord-274141-vujx538o 204 44 . . . cord-274141-vujx538o 205 1 Whereas whereas IN cord-274141-vujx538o 205 2 the the DT cord-274141-vujx538o 205 3 antiviral antiviral JJ cord-274141-vujx538o 205 4 , , , cord-274141-vujx538o 205 5 anti anti JJ cord-274141-vujx538o 205 6 - - JJ cord-274141-vujx538o 205 7 bacterial bacterial JJ cord-274141-vujx538o 205 8 , , , cord-274141-vujx538o 205 9 and and CC cord-274141-vujx538o 205 10 anti anti JJ cord-274141-vujx538o 205 11 - - JJ cord-274141-vujx538o 205 12 cancer cancer JJ cord-274141-vujx538o 205 13 effects effect NNS cord-274141-vujx538o 205 14 were be VBD cord-274141-vujx538o 205 15 attributable attributable JJ cord-274141-vujx538o 205 16 to to IN cord-274141-vujx538o 205 17 essential essential JJ cord-274141-vujx538o 205 18 oils oil NNS cord-274141-vujx538o 205 19 such such JJ cord-274141-vujx538o 205 20 as as IN cord-274141-vujx538o 205 21 cinnamaldehyde cinnamaldehyde NNP cord-274141-vujx538o 205 22 ( ( -LRB- cord-274141-vujx538o 205 23 11 11 CD cord-274141-vujx538o 205 24 ) ) -RRB- cord-274141-vujx538o 205 25 , , , cord-274141-vujx538o 205 26 the the DT cord-274141-vujx538o 205 27 anti anti JJ cord-274141-vujx538o 205 28 - - JJ cord-274141-vujx538o 205 29 inflammatory inflammatory JJ cord-274141-vujx538o 205 30 actions action NNS cord-274141-vujx538o 205 31 of of IN cord-274141-vujx538o 205 32 cinnamon cinnamon NN cord-274141-vujx538o 205 33 water water NN cord-274141-vujx538o 205 34 extract extract NN cord-274141-vujx538o 205 35 were be VBD cord-274141-vujx538o 205 36 due due JJ cord-274141-vujx538o 205 37 to to IN cord-274141-vujx538o 205 38 the the DT cord-274141-vujx538o 205 39 presence presence NN cord-274141-vujx538o 205 40 of of IN cord-274141-vujx538o 205 41 polyphenols polyphenol NNS cord-274141-vujx538o 205 42 such such JJ cord-274141-vujx538o 205 43 as as IN cord-274141-vujx538o 205 44 flavonoids flavonoid NNS cord-274141-vujx538o 205 45 and and CC cord-274141-vujx538o 205 46 tannins tannin NNS cord-274141-vujx538o 205 47 . . . cord-274141-vujx538o 206 1 Molecular molecular JJ cord-274141-vujx538o 206 2 docking docking NN cord-274141-vujx538o 206 3 studies study NNS cord-274141-vujx538o 206 4 show show VBP cord-274141-vujx538o 206 5 that that IN cord-274141-vujx538o 206 6 11 11 CD cord-274141-vujx538o 206 7 may may MD cord-274141-vujx538o 206 8 block block VB cord-274141-vujx538o 206 9 the the DT cord-274141-vujx538o 206 10 attachment attachment NN cord-274141-vujx538o 206 11 of of IN cord-274141-vujx538o 206 12 SARC SARC NNP cord-274141-vujx538o 206 13 - - HYPH cord-274141-vujx538o 206 14 CoV-2 CoV-2 NNP cord-274141-vujx538o 206 15 , , , cord-274141-vujx538o 206 16 though though IN cord-274141-vujx538o 206 17 detailed detail VBN cord-274141-vujx538o 206 18 in in IN cord-274141-vujx538o 206 19 vitro vitro FW cord-274141-vujx538o 206 20 and and CC cord-274141-vujx538o 206 21 in in IN cord-274141-vujx538o 206 22 vivo vivo NNP cord-274141-vujx538o 206 23 studies study NNS cord-274141-vujx538o 206 24 are be VBP cord-274141-vujx538o 206 25 required require VBN cord-274141-vujx538o 206 26 to to TO cord-274141-vujx538o 206 27 confirm confirm VB cord-274141-vujx538o 206 28 its -PRON- PRP$ cord-274141-vujx538o 206 29 efficacy efficacy NN cord-274141-vujx538o 206 30 ( ( -LRB- cord-274141-vujx538o 206 31 Asif Asif NNP cord-274141-vujx538o 206 32 et et NNP cord-274141-vujx538o 206 33 al al NNP cord-274141-vujx538o 206 34 . . NNP cord-274141-vujx538o 206 35 2020 2020 CD cord-274141-vujx538o 206 36 ) ) -RRB- cord-274141-vujx538o 206 37 . . . cord-274141-vujx538o 207 1 Compound compound NN cord-274141-vujx538o 207 2 11 11 CD cord-274141-vujx538o 207 3 had have VBD cord-274141-vujx538o 207 4 the the DT cord-274141-vujx538o 207 5 lowest low JJS cord-274141-vujx538o 207 6 electronegativity electronegativity NN cord-274141-vujx538o 207 7 value value NN cord-274141-vujx538o 207 8 among among IN cord-274141-vujx538o 207 9 the the DT cord-274141-vujx538o 207 10 phytochemicals phytochemical NNS cord-274141-vujx538o 207 11 with with IN cord-274141-vujx538o 207 12 a a DT cord-274141-vujx538o 207 13 score score NN cord-274141-vujx538o 207 14 of of IN cord-274141-vujx538o 207 15 − − CD cord-274141-vujx538o 207 16 4.34 4.34 CD cord-274141-vujx538o 207 17 ; ; : cord-274141-vujx538o 207 18 binding bind VBG cord-274141-vujx538o 207 19 affinity affinity NN cord-274141-vujx538o 207 20 in in IN cord-274141-vujx538o 207 21 kilocalorie kilocalorie NN cord-274141-vujx538o 207 22 per per IN cord-274141-vujx538o 207 23 mole mole NN cord-274141-vujx538o 207 24 was be VBD cord-274141-vujx538o 207 25 − − NN cord-274141-vujx538o 207 26 5 5 CD cord-274141-vujx538o 208 1 ( ( -LRB- cord-274141-vujx538o 208 2 Asif Asif NNP cord-274141-vujx538o 208 3 et et NNP cord-274141-vujx538o 208 4 al al NNP cord-274141-vujx538o 208 5 . . . cord-274141-vujx538o 208 6 2020 2020 CD cord-274141-vujx538o 209 1 ; ; : cord-274141-vujx538o 209 2 Kulkarni Kulkarni NNP cord-274141-vujx538o 209 3 et et NNP cord-274141-vujx538o 209 4 al al NNP cord-274141-vujx538o 209 5 . . NNP cord-274141-vujx538o 209 6 2020 2020 CD cord-274141-vujx538o 209 7 ) ) -RRB- cord-274141-vujx538o 209 8 . . . cord-274141-vujx538o 210 1 Stilbene stilbene JJ cord-274141-vujx538o 210 2 derivatives derivative NNS cord-274141-vujx538o 210 3 displayed display VBD cord-274141-vujx538o 210 4 antiviral antiviral JJ cord-274141-vujx538o 210 5 activities activity NNS cord-274141-vujx538o 210 6 against against IN cord-274141-vujx538o 210 7 SARS SARS NNP cord-274141-vujx538o 210 8 - - HYPH cord-274141-vujx538o 210 9 CoV CoV NNP cord-274141-vujx538o 210 10 ) ) -RRB- cord-274141-vujx538o 210 11 . . . cord-274141-vujx538o 211 1 The the DT cord-274141-vujx538o 211 2 stilbenoid stilbenoid NNP cord-274141-vujx538o 211 3 resveratrol resveratrol NN cord-274141-vujx538o 211 4 ( ( -LRB- cord-274141-vujx538o 211 5 12 12 CD cord-274141-vujx538o 211 6 ) ) -RRB- cord-274141-vujx538o 211 7 exists exist VBZ cord-274141-vujx538o 211 8 widely widely RB cord-274141-vujx538o 211 9 in in IN cord-274141-vujx538o 211 10 different different JJ cord-274141-vujx538o 211 11 plants plant NNS cord-274141-vujx538o 211 12 including include VBG cord-274141-vujx538o 211 13 grape grape NN cord-274141-vujx538o 211 14 Vitis vitis NN cord-274141-vujx538o 211 15 vinifera vinifera NN cord-274141-vujx538o 211 16 L. L. NNP cord-274141-vujx538o 211 17 , , , cord-274141-vujx538o 211 18 Polygonum Polygonum NNP cord-274141-vujx538o 211 19 cuspidatum cuspidatum NN cord-274141-vujx538o 211 20 , , , cord-274141-vujx538o 211 21 and and CC cord-274141-vujx538o 211 22 cranberry cranberry NNP cord-274141-vujx538o 211 23 Vaccinium Vaccinium NNP cord-274141-vujx538o 211 24 macrocarpon macrocarpon NNP cord-274141-vujx538o 211 25 Aiton Aiton NNP cord-274141-vujx538o 212 1 ( ( -LRB- cord-274141-vujx538o 212 2 Lin Lin NNP cord-274141-vujx538o 212 3 et et NNP cord-274141-vujx538o 212 4 al al NNP cord-274141-vujx538o 212 5 . . . cord-274141-vujx538o 212 6 2017 2017 CD cord-274141-vujx538o 212 7 ) ) -RRB- cord-274141-vujx538o 212 8 . . . cord-274141-vujx538o 213 1 Resveratrol resveratrol NN cord-274141-vujx538o 213 2 inhibits inhibit VBZ cord-274141-vujx538o 213 3 various various JJ cord-274141-vujx538o 213 4 viral viral JJ cord-274141-vujx538o 213 5 infections infection NNS cord-274141-vujx538o 213 6 , , , cord-274141-vujx538o 213 7 including include VBG cord-274141-vujx538o 213 8 the the DT cord-274141-vujx538o 213 9 inhibition inhibition NN cord-274141-vujx538o 213 10 of of IN cord-274141-vujx538o 213 11 HIV HIV NNP cord-274141-vujx538o 213 12 and and CC cord-274141-vujx538o 213 13 SARS SARS NNP cord-274141-vujx538o 213 14 - - HYPH cord-274141-vujx538o 213 15 CoV CoV NNP cord-274141-vujx538o 213 16 replication replication NN cord-274141-vujx538o 213 17 . . . cord-274141-vujx538o 214 1 Compound compound NN cord-274141-vujx538o 214 2 12 12 CD cord-274141-vujx538o 214 3 was be VBD cord-274141-vujx538o 214 4 a a DT cord-274141-vujx538o 214 5 potent potent JJ cord-274141-vujx538o 214 6 in in IN cord-274141-vujx538o 214 7 vitro vitro FW cord-274141-vujx538o 214 8 inhibitor inhibitor NN cord-274141-vujx538o 214 9 of of IN cord-274141-vujx538o 214 10 SARS SARS NNP cord-274141-vujx538o 214 11 - - HYPH cord-274141-vujx538o 214 12 CoV CoV NNP cord-274141-vujx538o 214 13 ( ( -LRB- cord-274141-vujx538o 214 14 at at IN cord-274141-vujx538o 214 15 ≤ ≤ NNP cord-274141-vujx538o 214 16 0.5 0.5 CD cord-274141-vujx538o 214 17 mg mg NNP cord-274141-vujx538o 214 18 / / SYM cord-274141-vujx538o 214 19 ml ml NNP cord-274141-vujx538o 214 20 ) ) -RRB- cord-274141-vujx538o 214 21 and and CC cord-274141-vujx538o 214 22 MERS MERS NNP cord-274141-vujx538o 214 23 - - HYPH cord-274141-vujx538o 214 24 CoV CoV NNP cord-274141-vujx538o 214 25 , , , cord-274141-vujx538o 214 26 at at IN cord-274141-vujx538o 214 27 ≤ ≤ NNP cord-274141-vujx538o 214 28 62.5 62.5 CD cord-274141-vujx538o 214 29 μM μM NNP cord-274141-vujx538o 214 30 within within IN cord-274141-vujx538o 214 31 24 24 CD cord-274141-vujx538o 214 32 h h NN cord-274141-vujx538o 214 33 of of IN cord-274141-vujx538o 214 34 infection infection NN cord-274141-vujx538o 214 35 Lin Lin NNP cord-274141-vujx538o 214 36 et et NNP cord-274141-vujx538o 214 37 al al NNP cord-274141-vujx538o 214 38 . . . cord-274141-vujx538o 214 39 2017 2017 CD cord-274141-vujx538o 214 40 ) ) -RRB- cord-274141-vujx538o 214 41 . . . cord-274141-vujx538o 215 1 It -PRON- PRP cord-274141-vujx538o 215 2 was be VBD cord-274141-vujx538o 215 3 predicted predict VBN cord-274141-vujx538o 215 4 that that IN cord-274141-vujx538o 215 5 resveratrol resveratrol NN cord-274141-vujx538o 215 6 ( ( -LRB- cord-274141-vujx538o 215 7 12 12 CD cord-274141-vujx538o 215 8 ) ) -RRB- cord-274141-vujx538o 215 9 could could MD cord-274141-vujx538o 215 10 be be VB cord-274141-vujx538o 215 11 a a DT cord-274141-vujx538o 215 12 potential potential JJ cord-274141-vujx538o 215 13 agent agent NN cord-274141-vujx538o 215 14 against against IN cord-274141-vujx538o 215 15 new new JJ cord-274141-vujx538o 215 16 HCoVs hcovs CD cord-274141-vujx538o 215 17 in in IN cord-274141-vujx538o 215 18 the the DT cord-274141-vujx538o 215 19 near near JJ cord-274141-vujx538o 215 20 future future NN cord-274141-vujx538o 216 1 ( ( -LRB- cord-274141-vujx538o 216 2 Lin Lin NNP cord-274141-vujx538o 216 3 et et NNP cord-274141-vujx538o 216 4 al al NNP cord-274141-vujx538o 216 5 . . . cord-274141-vujx538o 216 6 2017 2017 CD cord-274141-vujx538o 216 7 ) ) -RRB- cord-274141-vujx538o 216 8 . . . cord-274141-vujx538o 217 1 Polysaccharides polysaccharide NNS cord-274141-vujx538o 217 2 isolated isolate VBN cord-274141-vujx538o 217 3 from from IN cord-274141-vujx538o 217 4 TCM TCM NNP cord-274141-vujx538o 217 5 herb herb NN cord-274141-vujx538o 217 6 Astragalus Astragalus NNP cord-274141-vujx538o 217 7 mongholicus mongholicus NNP cord-274141-vujx538o 217 8 Bunge Bunge NNP cord-274141-vujx538o 217 9 have have VBP cord-274141-vujx538o 217 10 been be VBN cord-274141-vujx538o 217 11 widely widely RB cord-274141-vujx538o 217 12 used use VBN cord-274141-vujx538o 217 13 to to TO cord-274141-vujx538o 217 14 boost boost VB cord-274141-vujx538o 217 15 immunity immunity NN cord-274141-vujx538o 217 16 against against IN cord-274141-vujx538o 217 17 viruses virus NNS cord-274141-vujx538o 217 18 . . . cord-274141-vujx538o 218 1 A a DT cord-274141-vujx538o 218 2 study study NN cord-274141-vujx538o 218 3 by by IN cord-274141-vujx538o 218 4 Zhang Zhang NNP cord-274141-vujx538o 218 5 et et NNP cord-274141-vujx538o 218 6 al al NNP cord-274141-vujx538o 218 7 . . . cord-274141-vujx538o 219 1 ( ( -LRB- cord-274141-vujx538o 219 2 2018 2018 CD cord-274141-vujx538o 219 3 ) ) -RRB- cord-274141-vujx538o 219 4 showed show VBD cord-274141-vujx538o 219 5 that that IN cord-274141-vujx538o 219 6 supplementation supplementation NN cord-274141-vujx538o 219 7 with with IN cord-274141-vujx538o 219 8 A. a. NN cord-274141-vujx538o 219 9 mongholicus mongholicus NN cord-274141-vujx538o 219 10 polysaccharides polysaccharide NNS cord-274141-vujx538o 219 11 can can MD cord-274141-vujx538o 219 12 inhibit inhibit VB cord-274141-vujx538o 219 13 the the DT cord-274141-vujx538o 219 14 replication replication NN cord-274141-vujx538o 219 15 of of IN cord-274141-vujx538o 219 16 avian avian JJ cord-274141-vujx538o 219 17 coronaviruses coronaviruse NNS cord-274141-vujx538o 219 18 . . . cord-274141-vujx538o 220 1 Extracts extract NNS cord-274141-vujx538o 220 2 of of IN cord-274141-vujx538o 220 3 Acanthopanax Acanthopanax NNP cord-274141-vujx538o 220 4 gracilistylus gracilistylus NNP cord-274141-vujx538o 220 5 var var NN cord-274141-vujx538o 220 6 . . . cord-274141-vujx538o 220 7 trifoliolatus trifoliolatus NNP cord-274141-vujx538o 220 8 C.B. C.B. NNP cord-274141-vujx538o 220 9 Shang Shang NNP cord-274141-vujx538o 220 10 , , , cord-274141-vujx538o 220 11 the the DT cord-274141-vujx538o 220 12 root root NN cord-274141-vujx538o 220 13 of of IN cord-274141-vujx538o 220 14 Sophora Sophora NNP cord-274141-vujx538o 220 15 flavescens flavescens NNP cord-274141-vujx538o 220 16 Aiton Aiton NNP cord-274141-vujx538o 220 17 , , , cord-274141-vujx538o 220 18 and and CC cord-274141-vujx538o 220 19 the the DT cord-274141-vujx538o 220 20 dried dry VBN cord-274141-vujx538o 220 21 root root NN cord-274141-vujx538o 220 22 of of IN cord-274141-vujx538o 220 23 Sanguisorba Sanguisorba NNP cord-274141-vujx538o 220 24 officinalis officinalis NN cord-274141-vujx538o 220 25 and and CC cord-274141-vujx538o 220 26 Torilis Torilis NNP cord-274141-vujx538o 220 27 elata elata FW cord-274141-vujx538o 220 28 Spreng Spreng NNP cord-274141-vujx538o 220 29 . . . cord-274141-vujx538o 221 1 reduced reduce VBN cord-274141-vujx538o 221 2 the the DT cord-274141-vujx538o 221 3 in in FW cord-274141-vujx538o 221 4 vitro vitro FW cord-274141-vujx538o 221 5 replication replication NN cord-274141-vujx538o 221 6 of of IN cord-274141-vujx538o 221 7 SARS SARS NNP cord-274141-vujx538o 221 8 - - HYPH cord-274141-vujx538o 221 9 CoV CoV NNP cord-274141-vujx538o 221 10 more more RBR cord-274141-vujx538o 221 11 potently potently RB cord-274141-vujx538o 221 12 than than IN cord-274141-vujx538o 221 13 the the DT cord-274141-vujx538o 221 14 ribavirin ribavirin NNP cord-274141-vujx538o 221 15 drug drug NN cord-274141-vujx538o 221 16 control control NN cord-274141-vujx538o 221 17 ( ( -LRB- cord-274141-vujx538o 221 18 Kim Kim NNP cord-274141-vujx538o 221 19 et et NNP cord-274141-vujx538o 221 20 al al NNP cord-274141-vujx538o 221 21 . . NNP cord-274141-vujx538o 221 22 2010 2010 CD cord-274141-vujx538o 221 23 ) ) -RRB- cord-274141-vujx538o 221 24 . . . cord-274141-vujx538o 222 1 Cimicifuga Cimicifuga NNP cord-274141-vujx538o 222 2 racemosa racemosa NN cord-274141-vujx538o 222 3 ( ( -LRB- cord-274141-vujx538o 222 4 L. L. NNP cord-274141-vujx538o 222 5 ) ) -RRB- cord-274141-vujx538o 222 6 Nutt Nutt NNP cord-274141-vujx538o 222 7 . . NNP cord-274141-vujx538o 222 8 , , , cord-274141-vujx538o 223 1 Melia Melia NNP cord-274141-vujx538o 223 2 azedarach azedarach NNP cord-274141-vujx538o 223 3 L. L. NNP cord-274141-vujx538o 223 4 , , , cord-274141-vujx538o 223 5 Coptis Coptis NNP cord-274141-vujx538o 223 6 chinensis chinensis NN cord-274141-vujx538o 223 7 Franch Franch NNP cord-274141-vujx538o 223 8 . . . cord-274141-vujx538o 224 1 , , , cord-274141-vujx538o 224 2 Phellodendron Phellodendron NNP cord-274141-vujx538o 224 3 chinense chinense NN cord-274141-vujx538o 224 4 C.K.Schneid C.K.Schneid NNP cord-274141-vujx538o 224 5 . . . cord-274141-vujx538o 225 1 , , , cord-274141-vujx538o 226 1 and and CC cord-274141-vujx538o 226 2 Sophora Sophora NNP cord-274141-vujx538o 226 3 tonkinensis tonkinensis NN cord-274141-vujx538o 226 4 var var NN cord-274141-vujx538o 226 5 . . . cord-274141-vujx538o 226 6 polyphylla polyphylla NNP cord-274141-vujx538o 226 7 X.C.Huang X.C.Huang NNP cord-274141-vujx538o 226 8 & & CC cord-274141-vujx538o 226 9 Z.C.Zhou Z.C.Zhou NNP cord-274141-vujx538o 226 10 decreased decrease VBD cord-274141-vujx538o 226 11 mouse mouse NN cord-274141-vujx538o 226 12 hepatitis hepatitis NN cord-274141-vujx538o 226 13 virus virus NN cord-274141-vujx538o 226 14 A59 A59 NNP cord-274141-vujx538o 226 15 ( ( -LRB- cord-274141-vujx538o 226 16 MHV MHV NNP cord-274141-vujx538o 226 17 - - HYPH cord-274141-vujx538o 226 18 A59 A59 NNP cord-274141-vujx538o 226 19 ) ) -RRB- cord-274141-vujx538o 226 20 production production NN cord-274141-vujx538o 226 21 and and CC cord-274141-vujx538o 226 22 intracellular intracellular JJ cord-274141-vujx538o 226 23 viral viral JJ cord-274141-vujx538o 226 24 RNA rna NN cord-274141-vujx538o 226 25 and and CC cord-274141-vujx538o 226 26 protein protein NN cord-274141-vujx538o 226 27 expression expression NN cord-274141-vujx538o 226 28 with with IN cord-274141-vujx538o 226 29 EC EC NNP cord-274141-vujx538o 226 30 50 50 CD cord-274141-vujx538o 226 31 values value NNS cord-274141-vujx538o 226 32 ranging range VBG cord-274141-vujx538o 226 33 from from IN cord-274141-vujx538o 226 34 2 2 CD cord-274141-vujx538o 226 35 to to IN cord-274141-vujx538o 226 36 27.5 27.5 CD cord-274141-vujx538o 226 37 μg μg NNP cord-274141-vujx538o 226 38 / / SYM cord-274141-vujx538o 226 39 ml ml NNP cord-274141-vujx538o 226 40 ( ( -LRB- cord-274141-vujx538o 226 41 Kim Kim NNP cord-274141-vujx538o 226 42 et et NNP cord-274141-vujx538o 226 43 al al NNP cord-274141-vujx538o 226 44 . . NNP cord-274141-vujx538o 226 45 2008 2008 CD cord-274141-vujx538o 226 46 ) ) -RRB- cord-274141-vujx538o 226 47 . . . cord-274141-vujx538o 227 1 Cimicifuga Cimicifuga NNP cord-274141-vujx538o 227 2 racemosa racemosa NN cord-274141-vujx538o 227 3 , , , cord-274141-vujx538o 227 4 M. M. NNP cord-274141-vujx538o 227 5 azedarach azedarach NNP cord-274141-vujx538o 227 6 , , , cord-274141-vujx538o 227 7 C. C. NNP cord-274141-vujx538o 227 8 chinensis chinensis NN cord-274141-vujx538o 227 9 , , , cord-274141-vujx538o 227 10 P. P. NNP cord-274141-vujx538o 227 11 chinense chinense NN cord-274141-vujx538o 227 12 , , , cord-274141-vujx538o 227 13 and and CC cord-274141-vujx538o 227 14 S. S. NNP cord-274141-vujx538o 227 15 tonkinensis tonkinensis NN cord-274141-vujx538o 227 16 were be VBD cord-274141-vujx538o 227 17 good good JJ cord-274141-vujx538o 227 18 candidates candidate NNS cord-274141-vujx538o 227 19 for for IN cord-274141-vujx538o 227 20 the the DT cord-274141-vujx538o 227 21 treatment treatment NN cord-274141-vujx538o 227 22 of of IN cord-274141-vujx538o 227 23 coronaviral coronaviral JJ cord-274141-vujx538o 227 24 infections infection NNS cord-274141-vujx538o 227 25 in in IN cord-274141-vujx538o 227 26 both both DT cord-274141-vujx538o 227 27 humans human NNS cord-274141-vujx538o 227 28 and and CC cord-274141-vujx538o 227 29 animals animal NNS cord-274141-vujx538o 228 1 ( ( -LRB- cord-274141-vujx538o 228 2 Kim Kim NNP cord-274141-vujx538o 228 3 et et NNP cord-274141-vujx538o 228 4 al al NNP cord-274141-vujx538o 228 5 . . NNP cord-274141-vujx538o 228 6 2008 2008 CD cord-274141-vujx538o 228 7 ) ) -RRB- cord-274141-vujx538o 228 8 . . . cord-274141-vujx538o 229 1 The the DT cord-274141-vujx538o 229 2 underlying underlying JJ cord-274141-vujx538o 229 3 antiviral antiviral JJ cord-274141-vujx538o 229 4 mechanism mechanism NN cord-274141-vujx538o 229 5 was be VBD cord-274141-vujx538o 229 6 most most RBS cord-274141-vujx538o 229 7 likely likely JJ cord-274141-vujx538o 229 8 due due IN cord-274141-vujx538o 229 9 to to IN cord-274141-vujx538o 229 10 the the DT cord-274141-vujx538o 229 11 inhibition inhibition NN cord-274141-vujx538o 229 12 of of IN cord-274141-vujx538o 229 13 RNA RNA NNP cord-274141-vujx538o 229 14 - - HYPH cord-274141-vujx538o 229 15 dependent dependent JJ cord-274141-vujx538o 229 16 RNA RNA NNP cord-274141-vujx538o 229 17 polymerase polymerase NN cord-274141-vujx538o 229 18 or or CC cord-274141-vujx538o 229 19 proteases protease NNS cord-274141-vujx538o 229 20 that that WDT cord-274141-vujx538o 229 21 are be VBP cord-274141-vujx538o 229 22 crucial crucial JJ cord-274141-vujx538o 229 23 for for IN cord-274141-vujx538o 229 24 coronavirus coronavirus NN cord-274141-vujx538o 229 25 RNA RNA NNP cord-274141-vujx538o 229 26 replication replication NN cord-274141-vujx538o 229 27 . . . cord-274141-vujx538o 230 1 Melia Melia NNP cord-274141-vujx538o 230 2 azedarach azedarach RB cord-274141-vujx538o 230 3 and and CC cord-274141-vujx538o 230 4 C. C. NNP cord-274141-vujx538o 230 5 chinensis chinensis NN cord-274141-vujx538o 230 6 may may MD cord-274141-vujx538o 230 7 also also RB cord-274141-vujx538o 230 8 affect affect VB cord-274141-vujx538o 230 9 virus virus NN cord-274141-vujx538o 230 10 assembly assembly NN cord-274141-vujx538o 230 11 or or CC cord-274141-vujx538o 230 12 release release NN cord-274141-vujx538o 230 13 . . . cord-274141-vujx538o 231 1 Silvestrol Silvestrol NNP cord-274141-vujx538o 231 2 ( ( -LRB- cord-274141-vujx538o 231 3 13 13 CD cord-274141-vujx538o 231 4 ) ) -RRB- cord-274141-vujx538o 231 5 , , , cord-274141-vujx538o 231 6 a a DT cord-274141-vujx538o 231 7 natural natural JJ cord-274141-vujx538o 231 8 cyclopenta[b]benzofuran cyclopenta[b]benzofuran NNP cord-274141-vujx538o 231 9 , , , cord-274141-vujx538o 231 10 isolated isolate VBN cord-274141-vujx538o 231 11 from from IN cord-274141-vujx538o 231 12 the the DT cord-274141-vujx538o 231 13 fruits fruit NNS cord-274141-vujx538o 231 14 and and CC cord-274141-vujx538o 231 15 twigs twig NNS cord-274141-vujx538o 231 16 of of IN cord-274141-vujx538o 231 17 Aglaia Aglaia NNP cord-274141-vujx538o 231 18 foveolata foveolata NNP cord-274141-vujx538o 231 19 Pannell Pannell NNP cord-274141-vujx538o 231 20 , , , cord-274141-vujx538o 231 21 at at IN cord-274141-vujx538o 231 22 0.6 0.6 CD cord-274141-vujx538o 231 23 - - SYM cord-274141-vujx538o 231 24 2 2 CD cord-274141-vujx538o 231 25 μM μm CD cord-274141-vujx538o 231 26 , , , cord-274141-vujx538o 231 27 inhibited inhibited JJ cord-274141-vujx538o 231 28 cap cap NN cord-274141-vujx538o 231 29 - - HYPH cord-274141-vujx538o 231 30 dependent dependent JJ cord-274141-vujx538o 231 31 viral viral JJ cord-274141-vujx538o 231 32 mRNA mrna NN cord-274141-vujx538o 231 33 translation translation NN cord-274141-vujx538o 231 34 of of IN cord-274141-vujx538o 231 35 HCoV-229E HCoV-229E NNP cord-274141-vujx538o 231 36 with with IN cord-274141-vujx538o 231 37 an an DT cord-274141-vujx538o 231 38 IC IC NNP cord-274141-vujx538o 231 39 50 50 CD cord-274141-vujx538o 231 40 of of IN cord-274141-vujx538o 231 41 40 40 CD cord-274141-vujx538o 231 42 nM nm NN cord-274141-vujx538o 232 1 ( ( -LRB- cord-274141-vujx538o 232 2 Müller Müller NNP cord-274141-vujx538o 232 3 et et NNP cord-274141-vujx538o 232 4 al al NNP cord-274141-vujx538o 232 5 . . . cord-274141-vujx538o 232 6 2018 2018 CD cord-274141-vujx538o 232 7 ) ) -RRB- cord-274141-vujx538o 232 8 . . . cord-274141-vujx538o 233 1 Ouabain Ouabain NNP cord-274141-vujx538o 233 2 ( ( -LRB- cord-274141-vujx538o 233 3 14 14 CD cord-274141-vujx538o 233 4 ) ) -RRB- cord-274141-vujx538o 233 5 , , , cord-274141-vujx538o 233 6 also also RB cord-274141-vujx538o 233 7 known know VBN cord-274141-vujx538o 233 8 as as IN cord-274141-vujx538o 233 9 g g NN cord-274141-vujx538o 233 10 - - HYPH cord-274141-vujx538o 233 11 strophanthin strophanthin NNP cord-274141-vujx538o 233 12 , , , cord-274141-vujx538o 233 13 is be VBZ cord-274141-vujx538o 233 14 a a DT cord-274141-vujx538o 233 15 toxic toxic JJ cord-274141-vujx538o 233 16 cardiac cardiac JJ cord-274141-vujx538o 233 17 glycoside glycoside NN cord-274141-vujx538o 233 18 that that WDT cord-274141-vujx538o 233 19 was be VBD cord-274141-vujx538o 233 20 traditionally traditionally RB cord-274141-vujx538o 233 21 used use VBN cord-274141-vujx538o 233 22 as as IN cord-274141-vujx538o 233 23 an an DT cord-274141-vujx538o 233 24 arrow arrow NN cord-274141-vujx538o 233 25 poison poison NN cord-274141-vujx538o 233 26 for for IN cord-274141-vujx538o 233 27 both both DT cord-274141-vujx538o 233 28 hunting hunting NN cord-274141-vujx538o 233 29 and and CC cord-274141-vujx538o 233 30 warfare warfare NN cord-274141-vujx538o 233 31 in in IN cord-274141-vujx538o 233 32 eastern eastern JJ cord-274141-vujx538o 233 33 Africa Africa NNP cord-274141-vujx538o 233 34 . . . cord-274141-vujx538o 234 1 However however RB cord-274141-vujx538o 234 2 , , , cord-274141-vujx538o 234 3 this this DT cord-274141-vujx538o 234 4 substance substance NN cord-274141-vujx538o 234 5 , , , cord-274141-vujx538o 234 6 in in IN cord-274141-vujx538o 234 7 lower low JJR cord-274141-vujx538o 234 8 doses dose NNS cord-274141-vujx538o 234 9 , , , cord-274141-vujx538o 234 10 can can MD cord-274141-vujx538o 234 11 be be VB cord-274141-vujx538o 234 12 used use VBN cord-274141-vujx538o 234 13 medically medically RB cord-274141-vujx538o 234 14 to to TO cord-274141-vujx538o 234 15 treat treat VB cord-274141-vujx538o 234 16 hypotension hypotension NN cord-274141-vujx538o 234 17 and and CC cord-274141-vujx538o 234 18 some some DT cord-274141-vujx538o 234 19 arrhythmias arrhythmia NNS cord-274141-vujx538o 234 20 . . . cord-274141-vujx538o 235 1 In in IN cord-274141-vujx538o 235 2 addition addition NN cord-274141-vujx538o 235 3 , , , cord-274141-vujx538o 235 4 ouabain ouabain NNP cord-274141-vujx538o 235 5 diminishes diminish VBZ cord-274141-vujx538o 235 6 SARS SARS NNP cord-274141-vujx538o 235 7 - - HYPH cord-274141-vujx538o 235 8 CoV cov NN cord-274141-vujx538o 235 9 titers titer NNS cord-274141-vujx538o 235 10 and and CC cord-274141-vujx538o 235 11 the the DT cord-274141-vujx538o 235 12 number number NN cord-274141-vujx538o 235 13 of of IN cord-274141-vujx538o 235 14 SARS SARS NNP cord-274141-vujx538o 235 15 - - HYPH cord-274141-vujx538o 235 16 CoV CoV NNP cord-274141-vujx538o 235 17 RNA RNA NNP cord-274141-vujx538o 235 18 copies copy NNS cord-274141-vujx538o 235 19 at at IN cord-274141-vujx538o 235 20 0 0 CD cord-274141-vujx538o 235 21 - - SYM cord-274141-vujx538o 235 22 3000 3000 CD cord-274141-vujx538o 235 23 nM nm NN cord-274141-vujx538o 235 24 ( ( -LRB- cord-274141-vujx538o 235 25 Yang Yang NNP cord-274141-vujx538o 235 26 et et NNP cord-274141-vujx538o 235 27 al al NNP cord-274141-vujx538o 235 28 . . . cord-274141-vujx538o 235 29 2018 2018 CD cord-274141-vujx538o 235 30 ) ) -RRB- cord-274141-vujx538o 235 31 . . . cord-274141-vujx538o 236 1 Wu Wu NNP cord-274141-vujx538o 236 2 et et NNP cord-274141-vujx538o 236 3 al al NNP cord-274141-vujx538o 236 4 . . . cord-274141-vujx538o 237 1 ( ( -LRB- cord-274141-vujx538o 237 2 2020 2020 CD cord-274141-vujx538o 237 3 ) ) -RRB- cord-274141-vujx538o 237 4 described describe VBD cord-274141-vujx538o 237 5 drug drug NN cord-274141-vujx538o 237 6 names name NNS cord-274141-vujx538o 237 7 , , , cord-274141-vujx538o 237 8 chemical chemical JJ cord-274141-vujx538o 237 9 structures structure NNS cord-274141-vujx538o 237 10 , , , cord-274141-vujx538o 237 11 pharmacological pharmacological JJ cord-274141-vujx538o 237 12 functions function NNS cord-274141-vujx538o 237 13 , , , cord-274141-vujx538o 237 14 and and CC cord-274141-vujx538o 237 15 sources source NNS cord-274141-vujx538o 237 16 of of IN cord-274141-vujx538o 237 17 20 20 CD cord-274141-vujx538o 237 18 potential potential JJ cord-274141-vujx538o 237 19 RdRp RdRp NNP cord-274141-vujx538o 237 20 inhibitors inhibitor NNS cord-274141-vujx538o 237 21 from from IN cord-274141-vujx538o 237 22 an an DT cord-274141-vujx538o 237 23 in in IN cord-274141-vujx538o 237 24 - - HYPH cord-274141-vujx538o 237 25 house house NN cord-274141-vujx538o 237 26 natural natural JJ cord-274141-vujx538o 237 27 product product NN cord-274141-vujx538o 237 28 database database NN cord-274141-vujx538o 237 29 . . . cord-274141-vujx538o 238 1 Their -PRON- PRP$ cord-274141-vujx538o 238 2 results result NNS cord-274141-vujx538o 238 3 were be VBD cord-274141-vujx538o 238 4 based base VBN cord-274141-vujx538o 238 5 on on IN cord-274141-vujx538o 238 6 computer computer NN cord-274141-vujx538o 238 7 virtual virtual JJ cord-274141-vujx538o 238 8 screening screening NN cord-274141-vujx538o 238 9 because because IN cord-274141-vujx538o 238 10 no no DT cord-274141-vujx538o 238 11 in in IN cord-274141-vujx538o 238 12 vitro vitro FW cord-274141-vujx538o 238 13 and and CC cord-274141-vujx538o 238 14 in in IN cord-274141-vujx538o 238 15 vivo vivo NN cord-274141-vujx538o 238 16 experiments experiment NNS cord-274141-vujx538o 238 17 were be VBD cord-274141-vujx538o 238 18 conducted conduct VBN cord-274141-vujx538o 238 19 . . . cord-274141-vujx538o 239 1 Andrographolide Andrographolide NNP cord-274141-vujx538o 239 2 has have VBZ cord-274141-vujx538o 239 3 been be VBN cord-274141-vujx538o 239 4 studied study VBN cord-274141-vujx538o 239 5 for for IN cord-274141-vujx538o 239 6 its -PRON- PRP$ cord-274141-vujx538o 239 7 effects effect NNS cord-274141-vujx538o 239 8 on on IN cord-274141-vujx538o 239 9 cell cell NN cord-274141-vujx538o 239 10 signaling signaling NN cord-274141-vujx538o 239 11 , , , cord-274141-vujx538o 239 12 immunomodulation immunomodulation NN cord-274141-vujx538o 239 13 , , , cord-274141-vujx538o 239 14 and and CC cord-274141-vujx538o 239 15 stroke stroke NN cord-274141-vujx538o 239 16 . . . cord-274141-vujx538o 240 1 Using use VBG cord-274141-vujx538o 240 2 computational computational JJ cord-274141-vujx538o 240 3 approaches approach NNS cord-274141-vujx538o 240 4 , , , cord-274141-vujx538o 240 5 Enmozhi Enmozhi NNP cord-274141-vujx538o 240 6 et et NNP cord-274141-vujx538o 240 7 al al NNP cord-274141-vujx538o 240 8 . . . cord-274141-vujx538o 241 1 ( ( -LRB- cord-274141-vujx538o 241 2 2020 2020 CD cord-274141-vujx538o 241 3 ) ) -RRB- cord-274141-vujx538o 241 4 showed show VBD cord-274141-vujx538o 241 5 that that IN cord-274141-vujx538o 241 6 andrographolide andrographolide NN cord-274141-vujx538o 241 7 ( ( -LRB- cord-274141-vujx538o 241 8 15 15 CD cord-274141-vujx538o 241 9 ) ) -RRB- cord-274141-vujx538o 241 10 , , , cord-274141-vujx538o 241 11 an an DT cord-274141-vujx538o 241 12 extremelly extremelly RB cord-274141-vujx538o 241 13 bitter bitter JJ cord-274141-vujx538o 241 14 labdane labdane NN cord-274141-vujx538o 241 15 diterpenoid diterpenoid NNP cord-274141-vujx538o 241 16 isolated isolate VBN cord-274141-vujx538o 241 17 from from IN cord-274141-vujx538o 241 18 Andrographis Andrographis NNP cord-274141-vujx538o 241 19 paniculata paniculata NN cord-274141-vujx538o 241 20 ( ( -LRB- cord-274141-vujx538o 241 21 Burm.f Burm.f NNP cord-274141-vujx538o 241 22 . . . cord-274141-vujx538o 241 23 ) ) -RRB- cord-274141-vujx538o 242 1 Wall Wall NNP cord-274141-vujx538o 242 2 . . . cord-274141-vujx538o 243 1 ex ex NNP cord-274141-vujx538o 243 2 Nees Nees NNP cord-274141-vujx538o 243 3 , , , cord-274141-vujx538o 243 4 docked dock VBN cord-274141-vujx538o 243 5 successfully successfully RB cord-274141-vujx538o 243 6 in in IN cord-274141-vujx538o 243 7 the the DT cord-274141-vujx538o 243 8 binding binding NN cord-274141-vujx538o 243 9 site site NN cord-274141-vujx538o 243 10 of of IN cord-274141-vujx538o 243 11 SARS SARS NNP cord-274141-vujx538o 243 12 - - HYPH cord-274141-vujx538o 243 13 CoV-2 CoV-2 NNP cord-274141-vujx538o 243 14 M M NNP cord-274141-vujx538o 243 15 pro pro JJ cord-274141-vujx538o 243 16 . . . cord-274141-vujx538o 244 1 The the DT cord-274141-vujx538o 244 2 molecule molecule NN cord-274141-vujx538o 244 3 obeys obey VBZ cord-274141-vujx538o 244 4 Lipinski Lipinski NNP cord-274141-vujx538o 244 5 's 's POS cord-274141-vujx538o 244 6 rule rule NN cord-274141-vujx538o 244 7 making make VBG cord-274141-vujx538o 244 8 it -PRON- PRP cord-274141-vujx538o 244 9 a a DT cord-274141-vujx538o 244 10 promising promising JJ cord-274141-vujx538o 244 11 compound compound NN cord-274141-vujx538o 244 12 to to TO cord-274141-vujx538o 244 13 treat treat VB cord-274141-vujx538o 245 1 COVID-19 covid-19 VB cord-274141-vujx538o 245 2 ( ( -LRB- cord-274141-vujx538o 245 3 Enmozhi Enmozhi NNP cord-274141-vujx538o 245 4 et et NNP cord-274141-vujx538o 245 5 al al NNP cord-274141-vujx538o 245 6 . . NNP cord-274141-vujx538o 245 7 2020 2020 CD cord-274141-vujx538o 245 8 ) ) -RRB- cord-274141-vujx538o 245 9 . . . cord-274141-vujx538o 246 1 Omacetaxine Omacetaxine NNP cord-274141-vujx538o 246 2 mepesuccinate mepesuccinate NNP cord-274141-vujx538o 246 3 ( ( -LRB- cord-274141-vujx538o 246 4 trade trade NN cord-274141-vujx538o 246 5 names name NNS cord-274141-vujx538o 246 6 Synribo Synribo NNP cord-274141-vujx538o 246 7 ) ) -RRB- cord-274141-vujx538o 246 8 , , , cord-274141-vujx538o 246 9 formerly formerly RB cord-274141-vujx538o 246 10 named name VBN cord-274141-vujx538o 246 11 as as IN cord-274141-vujx538o 246 12 homoharringtonine homoharringtonine NNP cord-274141-vujx538o 246 13 ( ( -LRB- cord-274141-vujx538o 246 14 16 16 CD cord-274141-vujx538o 246 15 ) ) -RRB- cord-274141-vujx538o 246 16 , , , cord-274141-vujx538o 246 17 is be VBZ cord-274141-vujx538o 246 18 a a DT cord-274141-vujx538o 246 19 plant plant NN cord-274141-vujx538o 246 20 alkaloid alkaloid NN cord-274141-vujx538o 246 21 derived derive VBN cord-274141-vujx538o 246 22 from from IN cord-274141-vujx538o 246 23 Cephalotaxus Cephalotaxus NNP cord-274141-vujx538o 246 24 fortunei fortunei NNP cord-274141-vujx538o 246 25 Hook Hook NNP cord-274141-vujx538o 246 26 that that WDT cord-274141-vujx538o 246 27 was be VBD cord-274141-vujx538o 246 28 approved approve VBN cord-274141-vujx538o 246 29 by by IN cord-274141-vujx538o 246 30 the the DT cord-274141-vujx538o 246 31 US US NNP cord-274141-vujx538o 246 32 FDA FDA NNP cord-274141-vujx538o 246 33 in in IN cord-274141-vujx538o 246 34 October October NNP cord-274141-vujx538o 246 35 2012 2012 CD cord-274141-vujx538o 246 36 for for IN cord-274141-vujx538o 246 37 the the DT cord-274141-vujx538o 246 38 treatment treatment NN cord-274141-vujx538o 246 39 of of IN cord-274141-vujx538o 246 40 chronic chronic JJ cord-274141-vujx538o 246 41 myeloid myeloid NN cord-274141-vujx538o 246 42 leukemia leukemia NN cord-274141-vujx538o 246 43 in in IN cord-274141-vujx538o 246 44 adults adult NNS cord-274141-vujx538o 246 45 . . . cord-274141-vujx538o 247 1 Homoharringtonine Homoharringtonine NNP cord-274141-vujx538o 247 2 has have VBZ cord-274141-vujx538o 247 3 been be VBN cord-274141-vujx538o 247 4 reported report VBN cord-274141-vujx538o 247 5 to to TO cord-274141-vujx538o 247 6 exhibit exhibit VB cord-274141-vujx538o 247 7 potent potent JJ cord-274141-vujx538o 247 8 inhibitory inhibitory JJ cord-274141-vujx538o 247 9 activity activity NN cord-274141-vujx538o 247 10 against against IN cord-274141-vujx538o 247 11 coronaviruses coronaviruse NNS cord-274141-vujx538o 247 12 , , , cord-274141-vujx538o 247 13 namely namely RB cord-274141-vujx538o 247 14 porcine porcine JJ cord-274141-vujx538o 247 15 epidemic epidemic NN cord-274141-vujx538o 247 16 diarrhea diarrhea NN cord-274141-vujx538o 247 17 virus virus NN cord-274141-vujx538o 247 18 , , , cord-274141-vujx538o 247 19 murine murine JJ cord-274141-vujx538o 247 20 hepatitis hepatitis NN cord-274141-vujx538o 247 21 virus virus NN cord-274141-vujx538o 247 22 ( ( -LRB- cord-274141-vujx538o 247 23 Dong Dong NNP cord-274141-vujx538o 247 24 et et FW cord-274141-vujx538o 247 25 al al NNP cord-274141-vujx538o 247 26 . . . cord-274141-vujx538o 247 27 2018 2018 CD cord-274141-vujx538o 248 1 ; ; : cord-274141-vujx538o 248 2 Andersen Andersen NNP cord-274141-vujx538o 248 3 et et NNP cord-274141-vujx538o 248 4 al al NNP cord-274141-vujx538o 248 5 . . . cord-274141-vujx538o 248 6 2019 2019 CD cord-274141-vujx538o 248 7 ) ) -RRB- cord-274141-vujx538o 248 8 , , , cord-274141-vujx538o 248 9 and and CC cord-274141-vujx538o 248 10 SARS SARS NNP cord-274141-vujx538o 248 11 - - HYPH cord-274141-vujx538o 248 12 CoV-2 CoV-2 NNP cord-274141-vujx538o 248 13 with with IN cord-274141-vujx538o 248 14 EC EC NNP cord-274141-vujx538o 248 15 50 50 CD cord-274141-vujx538o 248 16 at at IN cord-274141-vujx538o 248 17 2.10 2.10 CD cord-274141-vujx538o 249 1 μM μM NNP cord-274141-vujx538o 250 1 ( ( -LRB- cord-274141-vujx538o 250 2 Choy Choy NNP cord-274141-vujx538o 250 3 et et FW cord-274141-vujx538o 250 4 al al NNP cord-274141-vujx538o 250 5 . . NNP cord-274141-vujx538o 250 6 2020 2020 CD cord-274141-vujx538o 250 7 ) ) -RRB- cord-274141-vujx538o 250 8 . . . cord-274141-vujx538o 251 1 Tylophorine Tylophorine NNP cord-274141-vujx538o 251 2 ( ( -LRB- cord-274141-vujx538o 251 3 17 17 CD cord-274141-vujx538o 251 4 ) ) -RRB- cord-274141-vujx538o 251 5 , , , cord-274141-vujx538o 251 6 a a DT cord-274141-vujx538o 251 7 phenanthraindolizidine phenanthraindolizidine NN cord-274141-vujx538o 251 8 alkaloid alkaloid NN cord-274141-vujx538o 251 9 , , , cord-274141-vujx538o 251 10 has have VBZ cord-274141-vujx538o 251 11 anti anti JJ cord-274141-vujx538o 251 12 - - JJ cord-274141-vujx538o 251 13 HCoV hcov JJ cord-274141-vujx538o 251 14 activity activity NN cord-274141-vujx538o 251 15 in in IN cord-274141-vujx538o 251 16 the the DT cord-274141-vujx538o 251 17 nanomolar nanomolar NNP cord-274141-vujx538o 251 18 concentrations concentration NNS cord-274141-vujx538o 251 19 , , , cord-274141-vujx538o 251 20 up up IN cord-274141-vujx538o 251 21 to to IN cord-274141-vujx538o 251 22 1000 1000 CD cord-274141-vujx538o 251 23 nM nm NN cord-274141-vujx538o 251 24 . . . cord-274141-vujx538o 252 1 Tylophorine Tylophorine NNP cord-274141-vujx538o 252 2 derivatives derivative NNS cord-274141-vujx538o 252 3 , , , cord-274141-vujx538o 252 4 including include VBG cord-274141-vujx538o 252 5 naturally naturally RB cord-274141-vujx538o 252 6 occurring occur VBG cord-274141-vujx538o 252 7 and and CC cord-274141-vujx538o 252 8 synthetic synthetic JJ cord-274141-vujx538o 252 9 phenanthroindolizidines phenanthroindolizidine NNS cord-274141-vujx538o 252 10 and and CC cord-274141-vujx538o 252 11 phenanthroquinolizidines phenanthroquinolizidine NNS cord-274141-vujx538o 252 12 , , , cord-274141-vujx538o 252 13 have have VBP cord-274141-vujx538o 252 14 been be VBN cord-274141-vujx538o 252 15 identified identify VBN cord-274141-vujx538o 252 16 as as RB cord-274141-vujx538o 252 17 potent potent JJ cord-274141-vujx538o 252 18 in in IN cord-274141-vujx538o 252 19 vitro vitro FW cord-274141-vujx538o 252 20 inhibitors inhibitor NNS cord-274141-vujx538o 252 21 of of IN cord-274141-vujx538o 252 22 enteropathogenic enteropathogenic JJ cord-274141-vujx538o 252 23 coronavirus coronavirus NN cord-274141-vujx538o 252 24 transmissible transmissible JJ cord-274141-vujx538o 252 25 gastroenteritis gastroenteritis NN cord-274141-vujx538o 252 26 virus virus NN cord-274141-vujx538o 252 27 ( ( -LRB- cord-274141-vujx538o 252 28 TGEV TGEV NNP cord-274141-vujx538o 252 29 ) ) -RRB- cord-274141-vujx538o 252 30 . . . cord-274141-vujx538o 253 1 This this DT cord-274141-vujx538o 253 2 class class NN cord-274141-vujx538o 253 3 of of IN cord-274141-vujx538o 253 4 potent potent JJ cord-274141-vujx538o 253 5 compounds compound NNS cord-274141-vujx538o 253 6 showed show VBD cord-274141-vujx538o 253 7 EC EC NNP cord-274141-vujx538o 253 8 50 50 CD cord-274141-vujx538o 253 9 values value NNS cord-274141-vujx538o 253 10 ranging range VBG cord-274141-vujx538o 253 11 from from IN cord-274141-vujx538o 253 12 8 8 CD cord-274141-vujx538o 253 13 to to IN cord-274141-vujx538o 253 14 1468 1468 CD cord-274141-vujx538o 253 15 nM nm NN cord-274141-vujx538o 253 16 as as IN cord-274141-vujx538o 253 17 determined determine VBN cord-274141-vujx538o 253 18 by by IN cord-274141-vujx538o 253 19 immunofluorescent immunofluorescent JJ cord-274141-vujx538o 253 20 assay assay NN cord-274141-vujx538o 253 21 of of IN cord-274141-vujx538o 253 22 the the DT cord-274141-vujx538o 253 23 expression expression NN cord-274141-vujx538o 253 24 of of IN cord-274141-vujx538o 253 25 TGEV TGEV NNP cord-274141-vujx538o 253 26 spike spike NN cord-274141-vujx538o 253 27 and and CC cord-274141-vujx538o 253 28 nucleocapsid nucleocapsid NN cord-274141-vujx538o 253 29 proteins protein NNS cord-274141-vujx538o 253 30 and and CC cord-274141-vujx538o 253 31 by by IN cord-274141-vujx538o 253 32 real real JJ cord-274141-vujx538o 253 33 - - HYPH cord-274141-vujx538o 253 34 time time NN cord-274141-vujx538o 253 35 qRT qRT NNP cord-274141-vujx538o 253 36 - - HYPH cord-274141-vujx538o 253 37 PCR PCR NNP cord-274141-vujx538o 253 38 analysis analysis NN cord-274141-vujx538o 253 39 of of IN cord-274141-vujx538o 253 40 viral viral JJ cord-274141-vujx538o 253 41 yields yield NNS cord-274141-vujx538o 253 42 . . . cord-274141-vujx538o 254 1 Tylophorine Tylophorine NNP cord-274141-vujx538o 254 2 compounds compound NNS cord-274141-vujx538o 254 3 could could MD cord-274141-vujx538o 254 4 be be VB cord-274141-vujx538o 254 5 novel novel JJ cord-274141-vujx538o 254 6 leads lead NNS cord-274141-vujx538o 254 7 for for IN cord-274141-vujx538o 254 8 further further JJ cord-274141-vujx538o 254 9 drug drug NN cord-274141-vujx538o 254 10 development development NN cord-274141-vujx538o 254 11 on on IN cord-274141-vujx538o 254 12 their -PRON- PRP$ cord-274141-vujx538o 254 13 own own JJ cord-274141-vujx538o 254 14 or or CC cord-274141-vujx538o 254 15 as as IN cord-274141-vujx538o 254 16 templates template NNS cord-274141-vujx538o 254 17 for for IN cord-274141-vujx538o 254 18 drug drug NN cord-274141-vujx538o 254 19 design design NN cord-274141-vujx538o 254 20 . . . cord-274141-vujx538o 255 1 Tylophorine Tylophorine NNP cord-274141-vujx538o 255 2 and and CC cord-274141-vujx538o 255 3 related relate VBN cord-274141-vujx538o 255 4 alkaloids alkaloid NNS cord-274141-vujx538o 255 5 , , , cord-274141-vujx538o 255 6 isolated isolate VBN cord-274141-vujx538o 255 7 from from IN cord-274141-vujx538o 255 8 Tylophora Tylophora NNP cord-274141-vujx538o 255 9 indica indica NN cord-274141-vujx538o 255 10 Merr Merr NNP cord-274141-vujx538o 255 11 . . NNP cord-274141-vujx538o 255 12 , , , cord-274141-vujx538o 255 13 inhibit inhibit VB cord-274141-vujx538o 255 14 TGEV TGEV NNP cord-274141-vujx538o 255 15 replication replication NN cord-274141-vujx538o 255 16 for for IN cord-274141-vujx538o 255 17 anti anti JJ cord-274141-vujx538o 255 18 - - JJ cord-274141-vujx538o 255 19 coronavirus coronavirus JJ cord-274141-vujx538o 255 20 activity activity NN cord-274141-vujx538o 255 21 and and CC cord-274141-vujx538o 255 22 suppress suppress VB cord-274141-vujx538o 255 23 nitric nitric NN cord-274141-vujx538o 255 24 oxide oxide NN cord-274141-vujx538o 255 25 production production NN cord-274141-vujx538o 255 26 in in IN cord-274141-vujx538o 255 27 RAW264.7 RAW264.7 NNP cord-274141-vujx538o 255 28 cells cell NNS cord-274141-vujx538o 255 29 , , , cord-274141-vujx538o 255 30 a a DT cord-274141-vujx538o 255 31 measure measure NN cord-274141-vujx538o 255 32 of of IN cord-274141-vujx538o 255 33 antiinflammation antiinflammation NN cord-274141-vujx538o 256 1 ( ( -LRB- cord-274141-vujx538o 256 2 Lee Lee NNP cord-274141-vujx538o 256 3 et et NNP cord-274141-vujx538o 256 4 al al NNP cord-274141-vujx538o 256 5 . . NNP cord-274141-vujx538o 256 6 , , , cord-274141-vujx538o 256 7 2012a 2012a CD cord-274141-vujx538o 256 8 , , , cord-274141-vujx538o 256 9 b b LS cord-274141-vujx538o 256 10 ) ) -RRB- cord-274141-vujx538o 256 11 . . . cord-274141-vujx538o 257 1 Additionally additionally RB cord-274141-vujx538o 257 2 , , , cord-274141-vujx538o 257 3 a a DT cord-274141-vujx538o 257 4 pharmacokinetic pharmacokinetic JJ cord-274141-vujx538o 257 5 study study NN cord-274141-vujx538o 257 6 demonstrated demonstrate VBD cord-274141-vujx538o 257 7 high high JJ cord-274141-vujx538o 257 8 and and CC cord-274141-vujx538o 257 9 comparable comparable JJ cord-274141-vujx538o 257 10 oral oral JJ cord-274141-vujx538o 257 11 bioavailabilities bioavailabilitie NNS cord-274141-vujx538o 257 12 of of IN cord-274141-vujx538o 257 13 tylophorine tylophorine NN cord-274141-vujx538o 257 14 ( ( -LRB- cord-274141-vujx538o 257 15 65.7 65.7 CD cord-274141-vujx538o 257 16 % % NN cord-274141-vujx538o 257 17 ) ) -RRB- cord-274141-vujx538o 257 18 in in IN cord-274141-vujx538o 257 19 rats rat NNS cord-274141-vujx538o 257 20 ( ( -LRB- cord-274141-vujx538o 257 21 Lee Lee NNP cord-274141-vujx538o 257 22 et et NNP cord-274141-vujx538o 257 23 al al NNP cord-274141-vujx538o 257 24 . . NNP cord-274141-vujx538o 257 25 , , , cord-274141-vujx538o 257 26 2012a 2012a CD cord-274141-vujx538o 257 27 , , , cord-274141-vujx538o 257 28 b b LS cord-274141-vujx538o 257 29 ) ) -RRB- cord-274141-vujx538o 257 30 . . . cord-274141-vujx538o 258 1 The the DT cord-274141-vujx538o 258 2 chymotrypsin chymotrypsin NN cord-274141-vujx538o 258 3 - - HYPH cord-274141-vujx538o 258 4 like like JJ cord-274141-vujx538o 258 5 protease protease NN cord-274141-vujx538o 258 6 ( ( -LRB- cord-274141-vujx538o 258 7 3CL 3CL NNP cord-274141-vujx538o 258 8 pro pro JJ cord-274141-vujx538o 258 9 ) ) -RRB- cord-274141-vujx538o 258 10 is be VBZ cord-274141-vujx538o 258 11 vital vital JJ cord-274141-vujx538o 258 12 for for IN cord-274141-vujx538o 258 13 SARs SARs NNP cord-274141-vujx538o 258 14 - - HYPH cord-274141-vujx538o 258 15 CoV cov NN cord-274141-vujx538o 258 16 replication replication NN cord-274141-vujx538o 258 17 and and CC cord-274141-vujx538o 258 18 is be VBZ cord-274141-vujx538o 258 19 therefore therefore RB cord-274141-vujx538o 258 20 a a DT cord-274141-vujx538o 258 21 promising promising JJ cord-274141-vujx538o 258 22 drug drug NN cord-274141-vujx538o 258 23 target target NN cord-274141-vujx538o 258 24 . . . cord-274141-vujx538o 259 1 The the DT cord-274141-vujx538o 259 2 active active JJ cord-274141-vujx538o 259 3 site site NN cord-274141-vujx538o 259 4 of of IN cord-274141-vujx538o 259 5 SARS SARS NNP cord-274141-vujx538o 259 6 - - HYPH cord-274141-vujx538o 259 7 CoV CoV NNP cord-274141-vujx538o 259 8 3CL 3CL NNP cord-274141-vujx538o 259 9 pro pro NNP cord-274141-vujx538o 259 10 has have VBZ cord-274141-vujx538o 259 11 a a DT cord-274141-vujx538o 259 12 catalytic catalytic JJ cord-274141-vujx538o 259 13 dyad dyad NN cord-274141-vujx538o 259 14 with with IN cord-274141-vujx538o 259 15 the the DT cord-274141-vujx538o 259 16 sulfur sulfur NN cord-274141-vujx538o 259 17 of of IN cord-274141-vujx538o 259 18 Cys145 cys145 CD cord-274141-vujx538o 259 19 as as IN cord-274141-vujx538o 259 20 a a DT cord-274141-vujx538o 259 21 nucleophile nucleophile NN cord-274141-vujx538o 259 22 and and CC cord-274141-vujx538o 259 23 the the DT cord-274141-vujx538o 259 24 imidazole imidazole JJ cord-274141-vujx538o 259 25 ring ring NN cord-274141-vujx538o 259 26 of of IN cord-274141-vujx538o 259 27 His41 His41 NNP cord-274141-vujx538o 259 28 as as IN cord-274141-vujx538o 259 29 a a DT cord-274141-vujx538o 259 30 general general JJ cord-274141-vujx538o 259 31 base base NN cord-274141-vujx538o 260 1 ( ( -LRB- cord-274141-vujx538o 260 2 Ryu Ryu NNP cord-274141-vujx538o 260 3 et et FW cord-274141-vujx538o 260 4 al al NNP cord-274141-vujx538o 260 5 . . NNP cord-274141-vujx538o 260 6 2010a 2010a CD cord-274141-vujx538o 260 7 ) ) -RRB- cord-274141-vujx538o 260 8 . . . cord-274141-vujx538o 261 1 Also also RB cord-274141-vujx538o 261 2 called call VBN cord-274141-vujx538o 261 3 main main JJ cord-274141-vujx538o 261 4 protease protease NN cord-274141-vujx538o 261 5 ( ( -LRB- cord-274141-vujx538o 261 6 M M NNP cord-274141-vujx538o 261 7 pro pro FW cord-274141-vujx538o 261 8 ) ) -RRB- cord-274141-vujx538o 261 9 , , , cord-274141-vujx538o 261 10 the the DT cord-274141-vujx538o 261 11 3CL 3cl CD cord-274141-vujx538o 261 12 pro pro NN cord-274141-vujx538o 261 13 of of IN cord-274141-vujx538o 261 14 SARS SARS NNP cord-274141-vujx538o 261 15 - - HYPH cord-274141-vujx538o 261 16 CoV CoV NNP cord-274141-vujx538o 261 17 mediates mediate VBZ cord-274141-vujx538o 261 18 the the DT cord-274141-vujx538o 261 19 proteolytic proteolytic JJ cord-274141-vujx538o 261 20 processing processing NN cord-274141-vujx538o 261 21 of of IN cord-274141-vujx538o 261 22 replicase replicase NN cord-274141-vujx538o 261 23 polypeptides polypeptide NNS cord-274141-vujx538o 261 24 1a 1a CD cord-274141-vujx538o 261 25 and and CC cord-274141-vujx538o 261 26 1ab 1ab CD cord-274141-vujx538o 261 27 into into IN cord-274141-vujx538o 261 28 functional functional JJ cord-274141-vujx538o 261 29 proteins protein NNS cord-274141-vujx538o 261 30 ; ; : cord-274141-vujx538o 261 31 thus thus RB cord-274141-vujx538o 261 32 , , , cord-274141-vujx538o 261 33 it -PRON- PRP cord-274141-vujx538o 261 34 is be VBZ cord-274141-vujx538o 261 35 an an DT cord-274141-vujx538o 261 36 important important JJ cord-274141-vujx538o 261 37 target target NN cord-274141-vujx538o 261 38 for for IN cord-274141-vujx538o 261 39 drug drug NN cord-274141-vujx538o 261 40 development development NN cord-274141-vujx538o 261 41 . . . cord-274141-vujx538o 262 1 Curcumin curcumin NN cord-274141-vujx538o 262 2 inhibits inhibit VBZ cord-274141-vujx538o 262 3 SARS SARS NNP cord-274141-vujx538o 262 4 - - HYPH cord-274141-vujx538o 262 5 CoV CoV NNP cord-274141-vujx538o 262 6 3CL 3CL NNP cord-274141-vujx538o 262 7 pro pro JJ cord-274141-vujx538o 262 8 ( ( -LRB- cord-274141-vujx538o 262 9 IC IC NNP cord-274141-vujx538o 262 10 50 50 CD cord-274141-vujx538o 262 11 value value NN cord-274141-vujx538o 262 12 of of IN cord-274141-vujx538o 262 13 23.5 23.5 CD cord-274141-vujx538o 262 14 μM μm NN cord-274141-vujx538o 262 15 ) ) -RRB- cord-274141-vujx538o 263 1 ( ( -LRB- cord-274141-vujx538o 263 2 Ryu Ryu NNP cord-274141-vujx538o 263 3 et et FW cord-274141-vujx538o 263 4 al al NNP cord-274141-vujx538o 263 5 . . NNP cord-274141-vujx538o 263 6 2010a 2010a CD cord-274141-vujx538o 263 7 ) ) -RRB- cord-274141-vujx538o 263 8 . . . cord-274141-vujx538o 264 1 The the DT cord-274141-vujx538o 264 2 extracts extract NNS cord-274141-vujx538o 264 3 of of IN cord-274141-vujx538o 264 4 Cibotium Cibotium NNP cord-274141-vujx538o 264 5 barometz barometz NN cord-274141-vujx538o 264 6 ( ( -LRB- cord-274141-vujx538o 264 7 L. L. NNP cord-274141-vujx538o 264 8 ) ) -RRB- cord-274141-vujx538o 264 9 J.Sm J.Sm NNP cord-274141-vujx538o 264 10 . . . cord-274141-vujx538o 264 11 and and CC cord-274141-vujx538o 264 12 Dioscorea Dioscorea NNP cord-274141-vujx538o 264 13 batatas batatas FW cord-274141-vujx538o 264 14 Decne Decne NNP cord-274141-vujx538o 264 15 . . . cord-274141-vujx538o 265 1 also also RB cord-274141-vujx538o 265 2 inhibited inhibit VBN cord-274141-vujx538o 265 3 SARS SARS NNP cord-274141-vujx538o 265 4 - - HYPH cord-274141-vujx538o 265 5 CoV CoV NNP cord-274141-vujx538o 265 6 3CL 3CL NNP cord-274141-vujx538o 265 7 pro pro JJ cord-274141-vujx538o 265 8 activity activity NN cord-274141-vujx538o 265 9 with with IN cord-274141-vujx538o 265 10 IC IC NNP cord-274141-vujx538o 265 11 50 50 CD cord-274141-vujx538o 265 12 values value NNS cord-274141-vujx538o 265 13 of of IN cord-274141-vujx538o 265 14 39 39 CD cord-274141-vujx538o 265 15 μg μg NN cord-274141-vujx538o 265 16 / / SYM cord-274141-vujx538o 265 17 ml ml NN cord-274141-vujx538o 265 18 and and CC cord-274141-vujx538o 265 19 44 44 CD cord-274141-vujx538o 265 20 μg μg NNP cord-274141-vujx538o 265 21 / / SYM cord-274141-vujx538o 265 22 ml ml NNS cord-274141-vujx538o 265 23 , , , cord-274141-vujx538o 265 24 respectively respectively RB cord-274141-vujx538o 266 1 ( ( -LRB- cord-274141-vujx538o 266 2 Cuong Cuong NNP cord-274141-vujx538o 266 3 et et NNP cord-274141-vujx538o 266 4 al al NNP cord-274141-vujx538o 266 5 . . . cord-274141-vujx538o 266 6 2009 2009 CD cord-274141-vujx538o 267 1 ; ; : cord-274141-vujx538o 267 2 Wen Wen NNP cord-274141-vujx538o 267 3 et et NNP cord-274141-vujx538o 267 4 al al NNP cord-274141-vujx538o 267 5 . . NNP cord-274141-vujx538o 267 6 2011 2011 CD cord-274141-vujx538o 267 7 ) ) -RRB- cord-274141-vujx538o 267 8 . . . cord-274141-vujx538o 268 1 Tannic tannic JJ cord-274141-vujx538o 268 2 acid acid NN cord-274141-vujx538o 268 3 , , , cord-274141-vujx538o 268 4 3-isotheaflavin-3-gallate 3-isotheaflavin-3-gallate CD cord-274141-vujx538o 268 5 , , , cord-274141-vujx538o 268 6 and and CC cord-274141-vujx538o 268 7 theaflavin-3,3′digallate theaflavin-3,3′digallate NNP cord-274141-vujx538o 268 8 , , , cord-274141-vujx538o 268 9 three three CD cord-274141-vujx538o 268 10 phenolic phenolic JJ cord-274141-vujx538o 268 11 compounds compound NNS cord-274141-vujx538o 268 12 from from IN cord-274141-vujx538o 268 13 black black JJ cord-274141-vujx538o 268 14 tea tea NN cord-274141-vujx538o 268 15 , , , cord-274141-vujx538o 268 16 inhibit inhibit VB cord-274141-vujx538o 268 17 SARS SARS NNP cord-274141-vujx538o 268 18 - - HYPH cord-274141-vujx538o 268 19 CoV CoV NNP cord-274141-vujx538o 268 20 3CL 3CL NNP cord-274141-vujx538o 268 21 pro pro JJ cord-274141-vujx538o 268 22 with with IN cord-274141-vujx538o 268 23 IC IC NNP cord-274141-vujx538o 268 24 50 50 CD cord-274141-vujx538o 268 25 values value NNS cord-274141-vujx538o 268 26 of of IN cord-274141-vujx538o 268 27 3 3 CD cord-274141-vujx538o 268 28 , , , cord-274141-vujx538o 268 29 7 7 CD cord-274141-vujx538o 268 30 , , , cord-274141-vujx538o 268 31 and and CC cord-274141-vujx538o 268 32 9.5 9.5 CD cord-274141-vujx538o 268 33 μM μm CD cord-274141-vujx538o 268 34 , , , cord-274141-vujx538o 268 35 respectively respectively RB cord-274141-vujx538o 268 36 . . . cord-274141-vujx538o 269 1 Isatis Isatis NNP cord-274141-vujx538o 269 2 indigotica indigotica NN cord-274141-vujx538o 269 3 Fortune Fortune NNP cord-274141-vujx538o 269 4 root root NN cord-274141-vujx538o 269 5 extracts extract NNS cord-274141-vujx538o 269 6 were be VBD cord-274141-vujx538o 269 7 frequently frequently RB cord-274141-vujx538o 269 8 used use VBN cord-274141-vujx538o 269 9 as as IN cord-274141-vujx538o 269 10 a a DT cord-274141-vujx538o 269 11 remedy remedy NN cord-274141-vujx538o 269 12 during during IN cord-274141-vujx538o 269 13 the the DT cord-274141-vujx538o 269 14 2002/2003 2002/2003 CD cord-274141-vujx538o 269 15 SARS SARS NNP cord-274141-vujx538o 269 16 outbreak outbreak NN cord-274141-vujx538o 269 17 in in IN cord-274141-vujx538o 269 18 China China NNP cord-274141-vujx538o 269 19 . . . cord-274141-vujx538o 270 1 A a DT cord-274141-vujx538o 270 2 water water NN cord-274141-vujx538o 270 3 extract extract NN cord-274141-vujx538o 270 4 of of IN cord-274141-vujx538o 270 5 I. I. NNP cord-274141-vujx538o 270 6 indigotica indigotica NNP cord-274141-vujx538o 270 7 had have VBD cord-274141-vujx538o 270 8 anti anti JJ cord-274141-vujx538o 270 9 - - JJ cord-274141-vujx538o 270 10 SARS SARS NNP cord-274141-vujx538o 270 11 - - HYPH cord-274141-vujx538o 270 12 CoV CoV NNP cord-274141-vujx538o 270 13 3CL 3CL NNP cord-274141-vujx538o 270 14 pro pro JJ cord-274141-vujx538o 270 15 activity activity NN cord-274141-vujx538o 270 16 . . . cord-274141-vujx538o 271 1 The the DT cord-274141-vujx538o 271 2 root root NN cord-274141-vujx538o 271 3 extract extract NN cord-274141-vujx538o 271 4 of of IN cord-274141-vujx538o 271 5 I. I. NNP cord-274141-vujx538o 271 6 indigotica indigotica NNP cord-274141-vujx538o 271 7 contains contain VBZ cord-274141-vujx538o 271 8 indigo indigo NNP cord-274141-vujx538o 271 9 , , , cord-274141-vujx538o 271 10 indirubin indirubin NNP cord-274141-vujx538o 271 11 , , , cord-274141-vujx538o 271 12 indican indican NNP cord-274141-vujx538o 271 13 ( ( -LRB- cord-274141-vujx538o 271 14 indoxyl indoxyl NNP cord-274141-vujx538o 271 15 - - HYPH cord-274141-vujx538o 271 16 β β NN cord-274141-vujx538o 271 17 - - HYPH cord-274141-vujx538o 271 18 D d NN cord-274141-vujx538o 271 19 - - HYPH cord-274141-vujx538o 271 20 glucoside glucoside NN cord-274141-vujx538o 271 21 ) ) -RRB- cord-274141-vujx538o 271 22 , , , cord-274141-vujx538o 271 23 β β NN cord-274141-vujx538o 271 24 - - HYPH cord-274141-vujx538o 271 25 sitosterol sitosterol NNP cord-274141-vujx538o 271 26 , , , cord-274141-vujx538o 271 27 γ γ NN cord-274141-vujx538o 271 28 - - HYPH cord-274141-vujx538o 271 29 sitosterol sitosterol NNP cord-274141-vujx538o 271 30 , , , cord-274141-vujx538o 271 31 and and CC cord-274141-vujx538o 271 32 sinigrin sinigrin NNP cord-274141-vujx538o 271 33 ( ( -LRB- cord-274141-vujx538o 271 34 18 18 CD cord-274141-vujx538o 271 35 ) ) -RRB- cord-274141-vujx538o 271 36 . . . cord-274141-vujx538o 272 1 The the DT cord-274141-vujx538o 272 2 IC IC NNP cord-274141-vujx538o 272 3 50 50 CD cord-274141-vujx538o 272 4 in in IN cord-274141-vujx538o 272 5 the the DT cord-274141-vujx538o 272 6 cell cell NN cord-274141-vujx538o 272 7 - - HYPH cord-274141-vujx538o 272 8 free free JJ cord-274141-vujx538o 272 9 assays assay NNS cord-274141-vujx538o 272 10 was be VBD cord-274141-vujx538o 272 11 115 115 CD cord-274141-vujx538o 272 12 μM μM VBG cord-274141-vujx538o 272 13 for for IN cord-274141-vujx538o 272 14 β β NN cord-274141-vujx538o 272 15 - - HYPH cord-274141-vujx538o 272 16 sitosterol sitosterol NNP cord-274141-vujx538o 272 17 , , , cord-274141-vujx538o 272 18 121 121 CD cord-274141-vujx538o 272 19 μM μm NN cord-274141-vujx538o 272 20 for for IN cord-274141-vujx538o 272 21 sinigrin sinigrin NNP cord-274141-vujx538o 272 22 , , , cord-274141-vujx538o 272 23 and and CC cord-274141-vujx538o 272 24 300 300 CD cord-274141-vujx538o 272 25 μM μm NN cord-274141-vujx538o 272 26 for for IN cord-274141-vujx538o 272 27 indigo indigo NN cord-274141-vujx538o 272 28 . . . cord-274141-vujx538o 273 1 The the DT cord-274141-vujx538o 273 2 cell cell NN cord-274141-vujx538o 273 3 - - HYPH cord-274141-vujx538o 273 4 based base VBN cord-274141-vujx538o 273 5 assay assay NN cord-274141-vujx538o 273 6 indicated indicate VBD cord-274141-vujx538o 273 7 that that IN cord-274141-vujx538o 273 8 the the DT cord-274141-vujx538o 273 9 antioxidant antioxidant JJ cord-274141-vujx538o 273 10 sinigrin sinigrin NNS cord-274141-vujx538o 273 11 ( ( -LRB- cord-274141-vujx538o 273 12 IC IC NNP cord-274141-vujx538o 273 13 50 50 CD cord-274141-vujx538o 273 14 217 217 CD cord-274141-vujx538o 273 15 μM μm CD cord-274141-vujx538o 273 16 ) ) -RRB- cord-274141-vujx538o 273 17 was be VBD cord-274141-vujx538o 273 18 more more RBR cord-274141-vujx538o 273 19 efficient efficient JJ cord-274141-vujx538o 273 20 in in IN cord-274141-vujx538o 273 21 blocking block VBG cord-274141-vujx538o 273 22 the the DT cord-274141-vujx538o 273 23 cleavage cleavage NN cord-274141-vujx538o 273 24 processing processing NN cord-274141-vujx538o 273 25 of of IN cord-274141-vujx538o 273 26 the the DT cord-274141-vujx538o 273 27 3CL 3cl CD cord-274141-vujx538o 273 28 pro pro NNP cord-274141-vujx538o 273 29 than than IN cord-274141-vujx538o 273 30 indigo indigo NNP cord-274141-vujx538o 273 31 ( ( -LRB- cord-274141-vujx538o 273 32 IC IC NNP cord-274141-vujx538o 273 33 50 50 CD cord-274141-vujx538o 273 34 752 752 CD cord-274141-vujx538o 273 35 μM μM NNP cord-274141-vujx538o 273 36 ) ) -RRB- cord-274141-vujx538o 273 37 and and CC cord-274141-vujx538o 273 38 β β NN cord-274141-vujx538o 273 39 - - HYPH cord-274141-vujx538o 273 40 sitosterol sitosterol NNP cord-274141-vujx538o 274 1 ( ( -LRB- cord-274141-vujx538o 274 2 IC IC NNP cord-274141-vujx538o 274 3 50 50 CD cord-274141-vujx538o 274 4 1210 1210 CD cord-274141-vujx538o 274 5 μM μM NNP cord-274141-vujx538o 274 6 ) ) -RRB- cord-274141-vujx538o 274 7 . . . cord-274141-vujx538o 275 1 Compound Compound NNP cord-274141-vujx538o 275 2 18 18 CD cord-274141-vujx538o 275 3 is be VBZ cord-274141-vujx538o 275 4 a a DT cord-274141-vujx538o 275 5 glucosinolatetype glucosinolatetype NN cord-274141-vujx538o 275 6 compound compound NN cord-274141-vujx538o 275 7 also also RB cord-274141-vujx538o 275 8 found find VBD cord-274141-vujx538o 275 9 in in IN cord-274141-vujx538o 275 10 some some DT cord-274141-vujx538o 275 11 plants plant NNS cord-274141-vujx538o 275 12 of of IN cord-274141-vujx538o 275 13 the the DT cord-274141-vujx538o 275 14 family family NN cord-274141-vujx538o 275 15 Brassicaceae Brassicaceae NNP cord-274141-vujx538o 275 16 such such PDT cord-274141-vujx538o 275 17 a a DT cord-274141-vujx538o 275 18 Brussels Brussels NNP cord-274141-vujx538o 275 19 sprouts sprout NNS cord-274141-vujx538o 275 20 , , , cord-274141-vujx538o 275 21 broccoli broccoli NN cord-274141-vujx538o 275 22 , , , cord-274141-vujx538o 275 23 and and CC cord-274141-vujx538o 275 24 the the DT cord-274141-vujx538o 275 25 seeds seed NNS cord-274141-vujx538o 275 26 of of IN cord-274141-vujx538o 275 27 black black JJ cord-274141-vujx538o 275 28 mustard mustard NN cord-274141-vujx538o 276 1 ( ( -LRB- cord-274141-vujx538o 276 2 Brassica Brassica NNP cord-274141-vujx538o 276 3 nigra nigra NN cord-274141-vujx538o 276 4 ( ( -LRB- cord-274141-vujx538o 276 5 L. L. NNP cord-274141-vujx538o 276 6 ) ) -RRB- cord-274141-vujx538o 276 7 Andrz Andrz NNP cord-274141-vujx538o 276 8 . . . cord-274141-vujx538o 277 1 Echinaforce Echinaforce NNP cord-274141-vujx538o 277 2 ® ® VBP cord-274141-vujx538o 277 3 is be VBZ cord-274141-vujx538o 277 4 a a DT cord-274141-vujx538o 277 5 standardized standardized JJ cord-274141-vujx538o 277 6 preparation preparation NN cord-274141-vujx538o 277 7 extracted extract VBN cord-274141-vujx538o 277 8 from from IN cord-274141-vujx538o 277 9 freshly freshly RB cord-274141-vujx538o 277 10 harvested harvest VBN cord-274141-vujx538o 277 11 herb herb NN cord-274141-vujx538o 277 12 ( ( -LRB- cord-274141-vujx538o 277 13 herba herba NNP cord-274141-vujx538o 277 14 tintura tintura NNP cord-274141-vujx538o 277 15 2580 2580 CD cord-274141-vujx538o 277 16 mg/125 mg/125 NNP cord-274141-vujx538o 277 17 drops drop VBZ cord-274141-vujx538o 277 18 ) ) -RRB- cord-274141-vujx538o 277 19 and and CC cord-274141-vujx538o 277 20 roots root NNS cord-274141-vujx538o 277 21 ( ( -LRB- cord-274141-vujx538o 277 22 radix radix NNP cord-274141-vujx538o 277 23 tintura tintura NNP cord-274141-vujx538o 277 24 135 135 CD cord-274141-vujx538o 277 25 mg/125 mg/125 NN cord-274141-vujx538o 277 26 drops drop NNS cord-274141-vujx538o 277 27 ) ) -RRB- cord-274141-vujx538o 277 28 of of IN cord-274141-vujx538o 277 29 Echinacea Echinacea NNP cord-274141-vujx538o 277 30 purpurea purpurea NN cord-274141-vujx538o 277 31 ( ( -LRB- cord-274141-vujx538o 277 32 L. L. NNP cord-274141-vujx538o 277 33 ) ) -RRB- cord-274141-vujx538o 277 34 Moench Moench NNP cord-274141-vujx538o 277 35 plants plant NNS cord-274141-vujx538o 277 36 ( ( -LRB- cord-274141-vujx538o 277 37 purple purple JJ cord-274141-vujx538o 277 38 coneflower coneflower NNP cord-274141-vujx538o 277 39 ) ) -RRB- cord-274141-vujx538o 277 40 with with IN cord-274141-vujx538o 277 41 a a DT cord-274141-vujx538o 277 42 65 65 CD cord-274141-vujx538o 277 43 % % NN cord-274141-vujx538o 277 44 alcoholic alcoholic JJ cord-274141-vujx538o 277 45 solution solution NN cord-274141-vujx538o 277 46 ( ( -LRB- cord-274141-vujx538o 277 47 Schapowal Schapowal NNP cord-274141-vujx538o 277 48 2020 2020 CD cord-274141-vujx538o 277 49 ) ) -RRB- cord-274141-vujx538o 277 50 . . . cord-274141-vujx538o 278 1 Echinaforce Echinaforce NNP cord-274141-vujx538o 278 2 ® ® VBP cord-274141-vujx538o 278 3 reduces reduce VBZ cord-274141-vujx538o 278 4 the the DT cord-274141-vujx538o 278 5 infectivity infectivity NN cord-274141-vujx538o 278 6 of of IN cord-274141-vujx538o 278 7 HCoV-229E HCoV-229E NNP cord-274141-vujx538o 278 8 in in IN cord-274141-vujx538o 278 9 a a DT cord-274141-vujx538o 278 10 dose dose NN cord-274141-vujx538o 278 11 - - HYPH cord-274141-vujx538o 278 12 dependent dependent JJ cord-274141-vujx538o 278 13 manner manner NN cord-274141-vujx538o 278 14 . . . cord-274141-vujx538o 279 1 It -PRON- PRP cord-274141-vujx538o 279 2 inhibits inhibit VBZ cord-274141-vujx538o 279 3 HCoV-229E HCoV-229E NNP cord-274141-vujx538o 279 4 infection infection NN cord-274141-vujx538o 279 5 of of IN cord-274141-vujx538o 279 6 respiratory respiratory JJ cord-274141-vujx538o 279 7 epithelial epithelial JJ cord-274141-vujx538o 279 8 cells cell NNS cord-274141-vujx538o 279 9 ( ( -LRB- cord-274141-vujx538o 279 10 Schapowal Schapowal NNP cord-274141-vujx538o 279 11 2020 2020 CD cord-274141-vujx538o 279 12 ) ) -RRB- cord-274141-vujx538o 279 13 . . . cord-274141-vujx538o 280 1 HCoV-229E HCoV-229E NNP cord-274141-vujx538o 280 2 was be VBD cord-274141-vujx538o 280 3 irreversibly irreversibly RB cord-274141-vujx538o 280 4 inactivated inactivate VBN cord-274141-vujx538o 280 5 when when WRB cord-274141-vujx538o 280 6 exposed expose VBN cord-274141-vujx538o 280 7 to to IN cord-274141-vujx538o 281 1 Echinaforce echinaforce NN cord-274141-vujx538o 281 2 ® ® . cord-274141-vujx538o 281 3 ( ( -LRB- cord-274141-vujx538o 281 4 IC IC NNP cord-274141-vujx538o 281 5 50 50 CD cord-274141-vujx538o 281 6 of of IN cord-274141-vujx538o 281 7 3.2 3.2 CD cord-274141-vujx538o 281 8 μg μg NNP cord-274141-vujx538o 281 9 / / SYM cord-274141-vujx538o 281 10 ml ml NN cord-274141-vujx538o 281 11 ) ) -RRB- cord-274141-vujx538o 281 12 ( ( -LRB- cord-274141-vujx538o 281 13 Schapowal Schapowal NNP cord-274141-vujx538o 281 14 2020 2020 CD cord-274141-vujx538o 281 15 ) ) -RRB- cord-274141-vujx538o 281 16 . . . cord-274141-vujx538o 282 1 Echinaforce Echinaforce NNP cord-274141-vujx538o 282 2 ® ® RB cord-274141-vujx538o 282 3 showed show VBD cord-274141-vujx538o 282 4 a a DT cord-274141-vujx538o 282 5 dosedependent dosedependent NN cord-274141-vujx538o 282 6 reduction reduction NN cord-274141-vujx538o 282 7 of of IN cord-274141-vujx538o 282 8 HCoV HCoV NNP cord-274141-vujx538o 282 9 229E 229e CD cord-274141-vujx538o 282 10 infectivity infectivity NN cord-274141-vujx538o 282 11 with with IN cord-274141-vujx538o 282 12 an an DT cord-274141-vujx538o 282 13 IC IC NNP cord-274141-vujx538o 282 14 50 50 CD cord-274141-vujx538o 282 15 = = SYM cord-274141-vujx538o 282 16 9 9 CD cord-274141-vujx538o 282 17 ± ± NNP cord-274141-vujx538o 282 18 3 3 CD cord-274141-vujx538o 282 19 μg μg NNP cord-274141-vujx538o 282 20 / / SYM cord-274141-vujx538o 282 21 ml ml NN cord-274141-vujx538o 282 22 ( ( -LRB- cord-274141-vujx538o 282 23 Engler Engler NNP cord-274141-vujx538o 282 24 et et NNP cord-274141-vujx538o 282 25 al al NNP cord-274141-vujx538o 282 26 . . . cord-274141-vujx538o 282 27 2017 2017 CD cord-274141-vujx538o 282 28 ) ) -RRB- cord-274141-vujx538o 282 29 . . . cord-274141-vujx538o 283 1 Complete complete JJ cord-274141-vujx538o 283 2 neutralization neutralization NN cord-274141-vujx538o 283 3 was be VBD cord-274141-vujx538o 283 4 achieved achieve VBN cord-274141-vujx538o 283 5 with with IN cord-274141-vujx538o 283 6 50 50 CD cord-274141-vujx538o 283 7 μg μg NNS cord-274141-vujx538o 283 8 / / SYM cord-274141-vujx538o 283 9 ml ml NN cord-274141-vujx538o 283 10 ( ( -LRB- cord-274141-vujx538o 283 11 Engler Engler NNP cord-274141-vujx538o 283 12 et et NNP cord-274141-vujx538o 283 13 al al NNP cord-274141-vujx538o 283 14 . . . cord-274141-vujx538o 283 15 2017 2017 CD cord-274141-vujx538o 283 16 ) ) -RRB- cord-274141-vujx538o 283 17 . . . cord-274141-vujx538o 284 1 Similar similar JJ cord-274141-vujx538o 284 2 inhibition inhibition NN cord-274141-vujx538o 284 3 was be VBD cord-274141-vujx538o 284 4 observed observe VBN cord-274141-vujx538o 284 5 for for IN cord-274141-vujx538o 284 6 MERS MERS NNP cord-274141-vujx538o 284 7 - - HYPH cord-274141-vujx538o 284 8 CoV CoV NNP cord-274141-vujx538o 284 9 when when WRB cord-274141-vujx538o 284 10 10 10 CD cord-274141-vujx538o 284 11 μg μg NN cord-274141-vujx538o 284 12 / / SYM cord-274141-vujx538o 284 13 ml ml NN cord-274141-vujx538o 284 14 of of IN cord-274141-vujx538o 284 15 Echinaforce Echinaforce NNP cord-274141-vujx538o 285 1 ® ® , cord-274141-vujx538o 285 2 reduced reduce VBN cord-274141-vujx538o 285 3 infectivity infectivity NN cord-274141-vujx538o 285 4 by by IN cord-274141-vujx538o 285 5 99.9 99.9 CD cord-274141-vujx538o 285 6 % % NN cord-274141-vujx538o 285 7 and and CC cord-274141-vujx538o 285 8 50 50 CD cord-274141-vujx538o 285 9 μg μg NNS cord-274141-vujx538o 285 10 / / SYM cord-274141-vujx538o 285 11 ml ml NN cord-274141-vujx538o 285 12 of of IN cord-274141-vujx538o 285 13 Echinaforce Echinaforce NNP cord-274141-vujx538o 286 1 fully fully RB cord-274141-vujx538o 286 2 blocked block VBN cord-274141-vujx538o 286 3 infectivity infectivity NN cord-274141-vujx538o 286 4 ( ( -LRB- cord-274141-vujx538o 286 5 Engler Engler NNP cord-274141-vujx538o 286 6 et et NNP cord-274141-vujx538o 286 7 al al NNP cord-274141-vujx538o 286 8 . . . cord-274141-vujx538o 286 9 2017 2017 CD cord-274141-vujx538o 286 10 ) ) -RRB- cord-274141-vujx538o 286 11 . . . cord-274141-vujx538o 287 1 Extracts extract NNS cord-274141-vujx538o 287 2 of of IN cord-274141-vujx538o 287 3 Echinacea Echinacea NNP cord-274141-vujx538o 287 4 purpurea purpurea NN cord-274141-vujx538o 287 5 have have VBP cord-274141-vujx538o 287 6 been be VBN cord-274141-vujx538o 287 7 used use VBN cord-274141-vujx538o 287 8 traditionally traditionally RB cord-274141-vujx538o 287 9 in in IN cord-274141-vujx538o 287 10 North North NNP cord-274141-vujx538o 287 11 America America NNP cord-274141-vujx538o 287 12 for for IN cord-274141-vujx538o 287 13 the the DT cord-274141-vujx538o 287 14 treatment treatment NN cord-274141-vujx538o 287 15 of of IN cord-274141-vujx538o 287 16 various various JJ cord-274141-vujx538o 287 17 infections infection NNS cord-274141-vujx538o 287 18 and and CC cord-274141-vujx538o 287 19 wounds wound NNS cord-274141-vujx538o 287 20 , , , cord-274141-vujx538o 287 21 and and CC cord-274141-vujx538o 287 22 they -PRON- PRP cord-274141-vujx538o 287 23 have have VBP cord-274141-vujx538o 287 24 become become VBN cord-274141-vujx538o 287 25 very very RB cord-274141-vujx538o 287 26 popular popular JJ cord-274141-vujx538o 287 27 herbal herbal JJ cord-274141-vujx538o 287 28 medicines medicine NNS cord-274141-vujx538o 287 29 globally globally RB cord-274141-vujx538o 287 30 ( ( -LRB- cord-274141-vujx538o 287 31 Hudson Hudson NNP cord-274141-vujx538o 287 32 2012 2012 CD cord-274141-vujx538o 287 33 ) ) -RRB- cord-274141-vujx538o 287 34 . . . cord-274141-vujx538o 288 1 Rondanelli Rondanelli NNP cord-274141-vujx538o 288 2 et et NNP cord-274141-vujx538o 288 3 al al NNP cord-274141-vujx538o 288 4 . . . cord-274141-vujx538o 289 1 ( ( -LRB- cord-274141-vujx538o 289 2 2018 2018 CD cord-274141-vujx538o 289 3 ) ) -RRB- cord-274141-vujx538o 289 4 found find VBD cord-274141-vujx538o 289 5 that that IN cord-274141-vujx538o 289 6 a a DT cord-274141-vujx538o 289 7 combination combination NN cord-274141-vujx538o 289 8 of of IN cord-274141-vujx538o 289 9 E. E. NNP cord-274141-vujx538o 289 10 purpurea purpurea NN cord-274141-vujx538o 289 11 , , , cord-274141-vujx538o 289 12 vitamin vitamin NN cord-274141-vujx538o 289 13 D d NN cord-274141-vujx538o 289 14 , , , cord-274141-vujx538o 289 15 vitamin vitamin NN cord-274141-vujx538o 289 16 C c NN cord-274141-vujx538o 289 17 , , , cord-274141-vujx538o 289 18 and and CC cord-274141-vujx538o 289 19 zinc zinc NN cord-274141-vujx538o 289 20 was be VBD cord-274141-vujx538o 289 21 useful useful JJ cord-274141-vujx538o 289 22 in in IN cord-274141-vujx538o 289 23 the the DT cord-274141-vujx538o 289 24 treatment treatment NN cord-274141-vujx538o 289 25 of of IN cord-274141-vujx538o 289 26 the the DT cord-274141-vujx538o 289 27 common common JJ cord-274141-vujx538o 289 28 cold cold NN cord-274141-vujx538o 289 29 . . . cord-274141-vujx538o 290 1 Vitamin vitamin NN cord-274141-vujx538o 290 2 D d NN cord-274141-vujx538o 290 3 supplementation supplementation NN cord-274141-vujx538o 290 4 also also RB cord-274141-vujx538o 290 5 lessens lessen VBZ cord-274141-vujx538o 290 6 the the DT cord-274141-vujx538o 290 7 risk risk NN cord-274141-vujx538o 290 8 of of IN cord-274141-vujx538o 290 9 COVID-19 covid-19 JJ cord-274141-vujx538o 290 10 infection infection NN cord-274141-vujx538o 290 11 and and CC cord-274141-vujx538o 290 12 deaths death NNS cord-274141-vujx538o 290 13 ( ( -LRB- cord-274141-vujx538o 290 14 Grant Grant NNP cord-274141-vujx538o 290 15 et et NNP cord-274141-vujx538o 290 16 al al NNP cord-274141-vujx538o 290 17 . . NNP cord-274141-vujx538o 290 18 2020 2020 CD cord-274141-vujx538o 290 19 ) ) -RRB- cord-274141-vujx538o 290 20 . . . cord-274141-vujx538o 291 1 Echinacea echinacea NN cord-274141-vujx538o 291 2 angustifolia angustifolia NN cord-274141-vujx538o 291 3 DC DC NNP cord-274141-vujx538o 291 4 . . . cord-274141-vujx538o 292 1 , , , cord-274141-vujx538o 292 2 Echinacea echinacea NN cord-274141-vujx538o 292 3 pallida pallida NNS cord-274141-vujx538o 292 4 ( ( -LRB- cord-274141-vujx538o 292 5 Nutt Nutt NNP cord-274141-vujx538o 292 6 . . . cord-274141-vujx538o 292 7 ) ) -RRB- cord-274141-vujx538o 293 1 Nutt Nutt NNP cord-274141-vujx538o 293 2 . . NNP cord-274141-vujx538o 293 3 , , , cord-274141-vujx538o 293 4 and and CC cord-274141-vujx538o 293 5 Echinacea Echinacea NNP cord-274141-vujx538o 293 6 purpurea purpurea NN cord-274141-vujx538o 293 7 are be VBP cord-274141-vujx538o 293 8 the the DT cord-274141-vujx538o 293 9 most most RBS cord-274141-vujx538o 293 10 common common JJ cord-274141-vujx538o 293 11 Echinacea Echinacea NNP cord-274141-vujx538o 293 12 Moench Moench NNP cord-274141-vujx538o 293 13 species specie NNS cord-274141-vujx538o 293 14 recognized recognize VBN cord-274141-vujx538o 293 15 for for IN cord-274141-vujx538o 293 16 treating treat VBG cord-274141-vujx538o 293 17 common common JJ cord-274141-vujx538o 293 18 cold cold NN cord-274141-vujx538o 293 19 and and CC cord-274141-vujx538o 293 20 SARS SARS NNP cord-274141-vujx538o 293 21 ( ( -LRB- cord-274141-vujx538o 293 22 Hudson Hudson NNP cord-274141-vujx538o 293 23 2012 2012 CD cord-274141-vujx538o 293 24 ) ) -RRB- cord-274141-vujx538o 293 25 . . . cord-274141-vujx538o 294 1 Coronavirus Coronavirus NNP cord-274141-vujx538o 294 2 infection infection NN cord-274141-vujx538o 294 3 in in IN cord-274141-vujx538o 294 4 humans human NNS cord-274141-vujx538o 294 5 is be VBZ cord-274141-vujx538o 294 6 characterized characterize VBN cord-274141-vujx538o 294 7 by by IN cord-274141-vujx538o 294 8 uncontrolled uncontrolled JJ cord-274141-vujx538o 294 9 replication replication NN cord-274141-vujx538o 294 10 of of IN cord-274141-vujx538o 294 11 the the DT cord-274141-vujx538o 294 12 virus virus NN cord-274141-vujx538o 294 13 and and CC cord-274141-vujx538o 294 14 a a DT cord-274141-vujx538o 294 15 prominent prominent JJ cord-274141-vujx538o 294 16 proinflammatory proinflammatory JJ cord-274141-vujx538o 294 17 response response NN cord-274141-vujx538o 294 18 ( ( -LRB- cord-274141-vujx538o 294 19 Wong Wong NNP cord-274141-vujx538o 294 20 and and CC cord-274141-vujx538o 294 21 Yuen Yuen NNP cord-274141-vujx538o 294 22 2008 2008 CD cord-274141-vujx538o 294 23 ) ) -RRB- cord-274141-vujx538o 294 24 . . . cord-274141-vujx538o 295 1 Still still RB cord-274141-vujx538o 295 2 , , , cord-274141-vujx538o 295 3 in in IN cord-274141-vujx538o 295 4 the the DT cord-274141-vujx538o 295 5 management management NN cord-274141-vujx538o 295 6 of of IN cord-274141-vujx538o 295 7 coronavirus coronavirus NN cord-274141-vujx538o 295 8 disease disease NN cord-274141-vujx538o 295 9 , , , cord-274141-vujx538o 295 10 the the DT cord-274141-vujx538o 295 11 role role NN cord-274141-vujx538o 295 12 of of IN cord-274141-vujx538o 295 13 immunomodulators immunomodulator NNS cord-274141-vujx538o 295 14 to to TO cord-274141-vujx538o 295 15 decrease decrease VB cord-274141-vujx538o 295 16 excessive excessive JJ cord-274141-vujx538o 295 17 inflammation inflammation NN cord-274141-vujx538o 295 18 remains remain VBZ cord-274141-vujx538o 295 19 elusive elusive JJ cord-274141-vujx538o 296 1 ( ( -LRB- cord-274141-vujx538o 296 2 Wong Wong NNP cord-274141-vujx538o 296 3 and and CC cord-274141-vujx538o 296 4 Yuen Yuen NNP cord-274141-vujx538o 296 5 2008 2008 CD cord-274141-vujx538o 296 6 ) ) -RRB- cord-274141-vujx538o 296 7 . . . cord-274141-vujx538o 297 1 The the DT cord-274141-vujx538o 297 2 immunomodulatory immunomodulatory JJ cord-274141-vujx538o 297 3 compounds compound VBZ cord-274141-vujx538o 297 4 tomentins tomentin VBZ cord-274141-vujx538o 297 5 A A NNP cord-274141-vujx538o 297 6 - - HYPH cord-274141-vujx538o 297 7 E e NN cord-274141-vujx538o 297 8 ( ( -LRB- cord-274141-vujx538o 297 9 19 19 CD cord-274141-vujx538o 297 10 - - SYM cord-274141-vujx538o 297 11 23 23 CD cord-274141-vujx538o 297 12 ) ) -RRB- cord-274141-vujx538o 297 13 , , , cord-274141-vujx538o 297 14 geranylated geranylated JJ cord-274141-vujx538o 297 15 flavonoids flavonoid NNS cord-274141-vujx538o 297 16 , , , cord-274141-vujx538o 297 17 isolated isolate VBN cord-274141-vujx538o 297 18 from from IN cord-274141-vujx538o 297 19 Paulownia Paulownia NNP cord-274141-vujx538o 297 20 tomentosa tomentosa VBN cord-274141-vujx538o 297 21 ( ( -LRB- cord-274141-vujx538o 297 22 Thunb Thunb NNP cord-274141-vujx538o 297 23 . . . cord-274141-vujx538o 297 24 ) ) -RRB- cord-274141-vujx538o 298 1 Steud Steud NNP cord-274141-vujx538o 298 2 . . . cord-274141-vujx538o 299 1 lower lower VB cord-274141-vujx538o 299 2 the the DT cord-274141-vujx538o 299 3 concentration concentration NN cord-274141-vujx538o 299 4 of of IN cord-274141-vujx538o 299 5 pro pro JJ cord-274141-vujx538o 299 6 - - JJ cord-274141-vujx538o 299 7 inflammatory inflammatory JJ cord-274141-vujx538o 299 8 cytokines cytokine NNS cord-274141-vujx538o 299 9 interleukin-1β interleukin-1β NNP cord-274141-vujx538o 299 10 and and CC cord-274141-vujx538o 299 11 tumor tumor NN cord-274141-vujx538o 299 12 necrosis necrosis NN cord-274141-vujx538o 299 13 factor factor NN cord-274141-vujx538o 299 14 alpha alpha NN cord-274141-vujx538o 299 15 . . . cord-274141-vujx538o 300 1 These these DT cord-274141-vujx538o 300 2 tomentins tomentin NNS cord-274141-vujx538o 300 3 could could MD cord-274141-vujx538o 300 4 be be VB cord-274141-vujx538o 300 5 useful useful JJ cord-274141-vujx538o 300 6 in in IN cord-274141-vujx538o 300 7 allaying allay VBG cord-274141-vujx538o 300 8 the the DT cord-274141-vujx538o 300 9 multisystem multisystem JJ cord-274141-vujx538o 300 10 inflammatory inflammatory JJ cord-274141-vujx538o 300 11 syndrome syndrome NN cord-274141-vujx538o 300 12 , , , cord-274141-vujx538o 300 13 also also RB cord-274141-vujx538o 300 14 known know VBN cord-274141-vujx538o 300 15 as as IN cord-274141-vujx538o 300 16 the the DT cord-274141-vujx538o 300 17 cytokine cytokine NN cord-274141-vujx538o 300 18 storm storm NN cord-274141-vujx538o 300 19 , , , cord-274141-vujx538o 300 20 seen see VBN cord-274141-vujx538o 300 21 in in IN cord-274141-vujx538o 300 22 many many JJ cord-274141-vujx538o 300 23 COVID-19 covid-19 JJ cord-274141-vujx538o 300 24 patients patient NNS cord-274141-vujx538o 300 25 . . . cord-274141-vujx538o 301 1 A a DT cord-274141-vujx538o 302 1 n n CC cord-274141-vujx538o 302 2 t t NNP cord-274141-vujx538o 303 1 i i PRP cord-274141-vujx538o 304 1 -i -i NNP cord-274141-vujx538o 304 2 n n CC cord-274141-vujx538o 304 3 f f NNP cord-274141-vujx538o 304 4 l l NNP cord-274141-vujx538o 304 5 a a NNP cord-274141-vujx538o 304 6 m m NNP cord-274141-vujx538o 304 7 m m NN cord-274141-vujx538o 304 8 a a DT cord-274141-vujx538o 304 9 t t NN cord-274141-vujx538o 304 10 o o NN cord-274141-vujx538o 304 11 r r NN cord-274141-vujx538o 304 12 y y NNP cord-274141-vujx538o 304 13 a a NNP cord-274141-vujx538o 304 14 n n NNP cord-274141-vujx538o 304 15 d d NNP cord-274141-vujx538o 304 16 a a NNP cord-274141-vujx538o 304 17 n n NN cord-274141-vujx538o 304 18 t t NN cord-274141-vujx538o 304 19 i i NN cord-274141-vujx538o 304 20 n n NN cord-274141-vujx538o 304 21 e e NN cord-274141-vujx538o 304 22 o o NN cord-274141-vujx538o 304 23 p p NN cord-274141-vujx538o 304 24 l l NN cord-274141-vujx538o 304 25 a a NN cord-274141-vujx538o 304 26 s s NN cord-274141-vujx538o 304 27 t t NN cord-274141-vujx538o 305 1 i i PRP cord-274141-vujx538o 306 1 c c NNP cord-274141-vujx538o 306 2 bisbenzylisoquinoline bisbenzylisoquinoline NNP cord-274141-vujx538o 306 3 alkaloids alkaloid NNS cord-274141-vujx538o 306 4 isolated isolate VBN cord-274141-vujx538o 306 5 from from IN cord-274141-vujx538o 306 6 Stephania Stephania NNP cord-274141-vujx538o 306 7 tetrandra tetrandra NNP cord-274141-vujx538o 306 8 S.Moore S.Moore NNP cord-274141-vujx538o 306 9 , , , cord-274141-vujx538o 306 10 namely namely RB cord-274141-vujx538o 306 11 cepharanthine cepharanthine NNP cord-274141-vujx538o 306 12 ( ( -LRB- cord-274141-vujx538o 306 13 24 24 CD cord-274141-vujx538o 306 14 ) ) -RRB- cord-274141-vujx538o 306 15 , , , cord-274141-vujx538o 306 16 fangchinoline fangchinoline NN cord-274141-vujx538o 306 17 , , , cord-274141-vujx538o 306 18 and and CC cord-274141-vujx538o 306 19 tetrandrine tetrandrine NNP cord-274141-vujx538o 306 20 , , , cord-274141-vujx538o 306 21 acted act VBD cord-274141-vujx538o 306 22 as as IN cord-274141-vujx538o 306 23 immunomodulators immunomodulator NNS cord-274141-vujx538o 306 24 and and CC cord-274141-vujx538o 306 25 inhibited inhibit VBD cord-274141-vujx538o 306 26 the the DT cord-274141-vujx538o 306 27 expression expression NN cord-274141-vujx538o 306 28 of of IN cord-274141-vujx538o 306 29 HCoV HCoV NNP cord-274141-vujx538o 306 30 - - HYPH cord-274141-vujx538o 306 31 OC43 OC43 NNP cord-274141-vujx538o 306 32 spike spike NN cord-274141-vujx538o 306 33 and and CC cord-274141-vujx538o 306 34 nucleocapsid nucleocapsid NN cord-274141-vujx538o 306 35 proteins protein NNS cord-274141-vujx538o 306 36 ( ( -LRB- cord-274141-vujx538o 306 37 Kim Kim NNP cord-274141-vujx538o 306 38 et et NNP cord-274141-vujx538o 306 39 al al NNP cord-274141-vujx538o 306 40 . . . cord-274141-vujx538o 306 41 2019 2019 CD cord-274141-vujx538o 306 42 ) ) -RRB- cord-274141-vujx538o 306 43 . . . cord-274141-vujx538o 307 1 After after IN cord-274141-vujx538o 307 2 the the DT cord-274141-vujx538o 307 3 cells cell NNS cord-274141-vujx538o 307 4 were be VBD cord-274141-vujx538o 307 5 infected infect VBN cord-274141-vujx538o 307 6 with with IN cord-274141-vujx538o 307 7 HCoV HCoV NNP cord-274141-vujx538o 307 8 - - HYPH cord-274141-vujx538o 307 9 OC43 OC43 NNP cord-274141-vujx538o 307 10 , , , cord-274141-vujx538o 307 11 each each DT cord-274141-vujx538o 307 12 compound compound NN cord-274141-vujx538o 307 13 ( ( -LRB- cord-274141-vujx538o 307 14 5 5 CD cord-274141-vujx538o 307 15 μM μM NNP cord-274141-vujx538o 307 16 ) ) -RRB- cord-274141-vujx538o 307 17 was be VBD cord-274141-vujx538o 307 18 added add VBN cord-274141-vujx538o 307 19 to to IN cord-274141-vujx538o 307 20 the the DT cord-274141-vujx538o 307 21 wells well NNS cord-274141-vujx538o 307 22 , , , cord-274141-vujx538o 307 23 and and CC cord-274141-vujx538o 307 24 cytokine cytokine NN cord-274141-vujx538o 307 25 mRNA mrna NN cord-274141-vujx538o 307 26 was be VBD cord-274141-vujx538o 307 27 qantified qantified JJ cord-274141-vujx538o 307 28 by by IN cord-274141-vujx538o 307 29 real real JJ cord-274141-vujx538o 307 30 - - HYPH cord-274141-vujx538o 307 31 time time NN cord-274141-vujx538o 307 32 qRT qRT NNP cord-274141-vujx538o 307 33 - - HYPH cord-274141-vujx538o 307 34 PCR PCR NNP cord-274141-vujx538o 307 35 . . . cord-274141-vujx538o 308 1 Compound compound NN cord-274141-vujx538o 308 2 treatment treatment NN cord-274141-vujx538o 308 3 following follow VBG cord-274141-vujx538o 308 4 virus virus NN cord-274141-vujx538o 308 5 infection infection NN cord-274141-vujx538o 308 6 reduced reduce VBD cord-274141-vujx538o 308 7 the the DT cord-274141-vujx538o 308 8 mRNA mrna NN cord-274141-vujx538o 308 9 expression expression NN cord-274141-vujx538o 308 10 levels level NNS cord-274141-vujx538o 308 11 of of IN cord-274141-vujx538o 308 12 IFN IFN NNP cord-274141-vujx538o 308 13 - - HYPH cord-274141-vujx538o 308 14 α1 α1 NNP cord-274141-vujx538o 308 15 by by IN cord-274141-vujx538o 308 16 almost almost RB cord-274141-vujx538o 308 17 20-fold 20-fold CD cord-274141-vujx538o 308 18 at at IN cord-274141-vujx538o 308 19 4 4 CD cord-274141-vujx538o 308 20 days day NNS cord-274141-vujx538o 308 21 post post NN cord-274141-vujx538o 308 22 infection infection NN cord-274141-vujx538o 308 23 , , , cord-274141-vujx538o 308 24 and and CC cord-274141-vujx538o 308 25 about about RB cord-274141-vujx538o 308 26 100-fold 100-fold CD cord-274141-vujx538o 308 27 reduction reduction NN cord-274141-vujx538o 308 28 for for IN cord-274141-vujx538o 308 29 IFN IFN NNP cord-274141-vujx538o 308 30 - - HYPH cord-274141-vujx538o 308 31 β1 β1 NNP cord-274141-vujx538o 308 32 at at IN cord-274141-vujx538o 308 33 3 3 CD cord-274141-vujx538o 308 34 days day NNS cord-274141-vujx538o 308 35 post post NN cord-274141-vujx538o 308 36 infection infection NN cord-274141-vujx538o 308 37 ( ( -LRB- cord-274141-vujx538o 308 38 Kim Kim NNP cord-274141-vujx538o 308 39 et et NNP cord-274141-vujx538o 308 40 al al NNP cord-274141-vujx538o 308 41 . . . cord-274141-vujx538o 308 42 2019 2019 CD cord-274141-vujx538o 308 43 ) ) -RRB- cord-274141-vujx538o 308 44 . . . cord-274141-vujx538o 309 1 According accord VBG cord-274141-vujx538o 309 2 to to IN cord-274141-vujx538o 309 3 Islam Islam NNP cord-274141-vujx538o 309 4 et et NNP cord-274141-vujx538o 309 5 al al NNP cord-274141-vujx538o 309 6 . . . cord-274141-vujx538o 310 1 ( ( -LRB- cord-274141-vujx538o 310 2 2020 2020 CD cord-274141-vujx538o 310 3 ) ) -RRB- cord-274141-vujx538o 310 4 , , , cord-274141-vujx538o 310 5 natural natural JJ cord-274141-vujx538o 310 6 products product NNS cord-274141-vujx538o 310 7 with with IN cord-274141-vujx538o 310 8 anticoronavirus anticoronavirus NN cord-274141-vujx538o 310 9 activity activity NN cord-274141-vujx538o 310 10 are be VBP cord-274141-vujx538o 310 11 major major JJ cord-274141-vujx538o 310 12 constituents constituent NNS cord-274141-vujx538o 310 13 of of IN cord-274141-vujx538o 310 14 common common JJ cord-274141-vujx538o 310 15 dietary dietary JJ cord-274141-vujx538o 310 16 supplements supplement NNS cord-274141-vujx538o 310 17 and and CC cord-274141-vujx538o 310 18 can can MD cord-274141-vujx538o 310 19 therefore therefore RB cord-274141-vujx538o 310 20 be be VB cord-274141-vujx538o 310 21 used use VBN cord-274141-vujx538o 310 22 to to TO cord-274141-vujx538o 310 23 improve improve VB cord-274141-vujx538o 310 24 the the DT cord-274141-vujx538o 310 25 immunity immunity NN cord-274141-vujx538o 310 26 of of IN cord-274141-vujx538o 310 27 the the DT cord-274141-vujx538o 310 28 general general JJ cord-274141-vujx538o 310 29 population population NN cord-274141-vujx538o 310 30 in in IN cord-274141-vujx538o 310 31 pandemics pandemic NNS cord-274141-vujx538o 310 32 such such JJ cord-274141-vujx538o 310 33 as as IN cord-274141-vujx538o 310 34 COVID-19 COVID-19 NNP cord-274141-vujx538o 310 35 . . . cord-274141-vujx538o 311 1 According accord VBG cord-274141-vujx538o 311 2 to to IN cord-274141-vujx538o 311 3 Kwon Kwon NNP cord-274141-vujx538o 311 4 et et NNP cord-274141-vujx538o 311 5 al al NNP cord-274141-vujx538o 311 6 . . . cord-274141-vujx538o 312 1 ( ( -LRB- cord-274141-vujx538o 312 2 2013 2013 CD cord-274141-vujx538o 312 3 ) ) -RRB- cord-274141-vujx538o 312 4 , , , cord-274141-vujx538o 312 5 five five CD cord-274141-vujx538o 312 6 phlorotannins phlorotannin NNS cord-274141-vujx538o 312 7 of of IN cord-274141-vujx538o 312 8 the the DT cord-274141-vujx538o 312 9 edible edible JJ cord-274141-vujx538o 312 10 brown brown JJ cord-274141-vujx538o 312 11 algae algae NN cord-274141-vujx538o 312 12 Ecklonia Ecklonia NNP cord-274141-vujx538o 312 13 cava cava NN cord-274141-vujx538o 312 14 Kjellman Kjellman NNP cord-274141-vujx538o 312 15 competitively competitively RB cord-274141-vujx538o 312 16 inhibit inhibit VBP cord-274141-vujx538o 312 17 the the DT cord-274141-vujx538o 312 18 binding binding NN cord-274141-vujx538o 312 19 of of IN cord-274141-vujx538o 312 20 SARS SARS NNP cord-274141-vujx538o 312 21 - - HYPH cord-274141-vujx538o 312 22 CoV CoV NNP cord-274141-vujx538o 312 23 spike spike NN cord-274141-vujx538o 312 24 protein protein NN cord-274141-vujx538o 312 25 to to IN cord-274141-vujx538o 312 26 sialic sialic JJ cord-274141-vujx538o 312 27 acids acid NNS cord-274141-vujx538o 312 28 at at IN cord-274141-vujx538o 312 29 a a DT cord-274141-vujx538o 312 30 concentration concentration NN cord-274141-vujx538o 312 31 of of IN cord-274141-vujx538o 312 32 less less JJR cord-274141-vujx538o 312 33 than than IN cord-274141-vujx538o 312 34 36.6 36.6 CD cord-274141-vujx538o 313 1 μM. μM. NNP cord-274141-vujx538o 313 2 Two two CD cord-274141-vujx538o 313 3 phlorotannins phlorotannin NNS cord-274141-vujx538o 313 4 caused cause VBD cord-274141-vujx538o 313 5 the the DT cord-274141-vujx538o 313 6 inhibition inhibition NN cord-274141-vujx538o 313 7 of of IN cord-274141-vujx538o 313 8 SARS SARS NNP cord-274141-vujx538o 313 9 - - HYPH cord-274141-vujx538o 313 10 CoV CoV NNP cord-274141-vujx538o 313 11 RNA RNA NNP cord-274141-vujx538o 313 12 and and CC cord-274141-vujx538o 313 13 SARS SARS NNP cord-274141-vujx538o 313 14 - - HYPH cord-274141-vujx538o 313 15 CoV CoV NNP cord-274141-vujx538o 313 16 protein protein NN cord-274141-vujx538o 313 17 synthesis synthesis NN cord-274141-vujx538o 313 18 in in IN cord-274141-vujx538o 313 19 late late JJ cord-274141-vujx538o 313 20 stages stage NNS cord-274141-vujx538o 313 21 , , , cord-274141-vujx538o 313 22 with with IN cord-274141-vujx538o 313 23 IC IC NNP cord-274141-vujx538o 313 24 50 50 CD cord-274141-vujx538o 313 25 values value NNS cord-274141-vujx538o 313 26 of of IN cord-274141-vujx538o 313 27 12.2 12.2 CD cord-274141-vujx538o 313 28 ± ± CD cord-274141-vujx538o 313 29 2.8 2.8 CD cord-274141-vujx538o 313 30 and and CC cord-274141-vujx538o 313 31 14.6 14.6 CD cord-274141-vujx538o 313 32 ± ± CD cord-274141-vujx538o 313 33 1.3 1.3 CD cord-274141-vujx538o 313 34 μM μm CD cord-274141-vujx538o 313 35 , , , cord-274141-vujx538o 313 36 respectively respectively RB cord-274141-vujx538o 313 37 . . . cord-274141-vujx538o 314 1 The the DT cord-274141-vujx538o 314 2 results result NNS cord-274141-vujx538o 314 3 suggest suggest VBP cord-274141-vujx538o 314 4 that that IN cord-274141-vujx538o 314 5 compounds compound NNS cord-274141-vujx538o 314 6 isolated isolate VBN cord-274141-vujx538o 314 7 from from IN cord-274141-vujx538o 314 8 E. E. NNP cord-274141-vujx538o 314 9 cava cava NNP cord-274141-vujx538o 314 10 have have VBP cord-274141-vujx538o 314 11 strong strong JJ cord-274141-vujx538o 314 12 antiviral antiviral JJ cord-274141-vujx538o 314 13 activity activity NN cord-274141-vujx538o 314 14 and and CC cord-274141-vujx538o 314 15 may may MD cord-274141-vujx538o 314 16 be be VB cord-274141-vujx538o 314 17 developed develop VBN cord-274141-vujx538o 314 18 into into IN cord-274141-vujx538o 314 19 natural natural JJ cord-274141-vujx538o 314 20 therapeutic therapeutic JJ cord-274141-vujx538o 314 21 drugs drug NNS cord-274141-vujx538o 314 22 against against IN cord-274141-vujx538o 314 23 SARS SARS NNP cord-274141-vujx538o 314 24 - - HYPH cord-274141-vujx538o 314 25 CoV CoV NNP cord-274141-vujx538o 314 26 infection infection NN cord-274141-vujx538o 314 27 . . . cord-274141-vujx538o 315 1 A a DT cord-274141-vujx538o 315 2 commercially commercially RB cord-274141-vujx538o 315 3 available available JJ cord-274141-vujx538o 315 4 E. E. NNP cord-274141-vujx538o 315 5 cava cava NN cord-274141-vujx538o 315 6 extract extract NN cord-274141-vujx538o 315 7 , , , cord-274141-vujx538o 315 8 Seapolynol Seapolynol NNP cord-274141-vujx538o 315 9 ™ ™ NN cord-274141-vujx538o 315 10 , , , cord-274141-vujx538o 315 11 was be VBD cord-274141-vujx538o 315 12 approved approve VBN cord-274141-vujx538o 315 13 as as IN cord-274141-vujx538o 315 14 a a DT cord-274141-vujx538o 315 15 new new JJ cord-274141-vujx538o 315 16 dietary dietary JJ cord-274141-vujx538o 315 17 ingredient ingredient NN cord-274141-vujx538o 315 18 ( ( -LRB- cord-274141-vujx538o 315 19 NDI NDI NNP cord-274141-vujx538o 315 20 ) ) -RRB- cord-274141-vujx538o 315 21 by by IN cord-274141-vujx538o 315 22 the the DT cord-274141-vujx538o 315 23 US US NNP cord-274141-vujx538o 315 24 Food Food NNP cord-274141-vujx538o 315 25 and and CC cord-274141-vujx538o 315 26 Drug Drug NNP cord-274141-vujx538o 315 27 Administration Administration NNP cord-274141-vujx538o 315 28 in in IN cord-274141-vujx538o 315 29 2008 2008 CD cord-274141-vujx538o 315 30 ( ( -LRB- cord-274141-vujx538o 315 31 FDA-1995-S-0039 FDA-1995-S-0039 NNP cord-274141-vujx538o 315 32 - - HYPH cord-274141-vujx538o 315 33 0176 0176 CD cord-274141-vujx538o 315 34 ) ) -RRB- cord-274141-vujx538o 316 1 ( ( -LRB- cord-274141-vujx538o 316 2 Lee Lee NNP cord-274141-vujx538o 316 3 et et NNP cord-274141-vujx538o 316 4 al al NNP cord-274141-vujx538o 316 5 . . NNP cord-274141-vujx538o 316 6 , , , cord-274141-vujx538o 316 7 2012a 2012a CD cord-274141-vujx538o 316 8 , , , cord-274141-vujx538o 316 9 b b LS cord-274141-vujx538o 316 10 ) ) -RRB- cord-274141-vujx538o 316 11 . . . cord-274141-vujx538o 317 1 An an DT cord-274141-vujx538o 317 2 ethanol ethanol NN cord-274141-vujx538o 317 3 extract extract NN cord-274141-vujx538o 317 4 of of IN cord-274141-vujx538o 317 5 the the DT cord-274141-vujx538o 317 6 edible edible JJ cord-274141-vujx538o 317 7 brown brown JJ cord-274141-vujx538o 317 8 algae algae NN cord-274141-vujx538o 317 9 Ecklonia Ecklonia NNP cord-274141-vujx538o 317 10 cava cava NN cord-274141-vujx538o 317 11 , , , cord-274141-vujx538o 317 12 Laminariaceae Laminariaceae NNP cord-274141-vujx538o 317 13 , , , cord-274141-vujx538o 317 14 contained contain VBD cord-274141-vujx538o 317 15 eight eight CD cord-274141-vujx538o 317 16 phlorotannins phlorotannin NNS cord-274141-vujx538o 317 17 that that WDT cord-274141-vujx538o 317 18 exhibited exhibit VBD cord-274141-vujx538o 317 19 a a DT cord-274141-vujx538o 317 20 dose dose NN cord-274141-vujx538o 317 21 - - HYPH cord-274141-vujx538o 317 22 dependent dependent JJ cord-274141-vujx538o 317 23 ( ( -LRB- cord-274141-vujx538o 317 24 competitive competitive JJ cord-274141-vujx538o 317 25 ) ) -RRB- cord-274141-vujx538o 317 26 inhibitory inhibitory JJ cord-274141-vujx538o 317 27 effect effect NN cord-274141-vujx538o 317 28 on on IN cord-274141-vujx538o 317 29 SARS SARS NNP cord-274141-vujx538o 317 30 - - HYPH cord-274141-vujx538o 317 31 CoV CoV NNP cord-274141-vujx538o 317 32 3CL 3CL NNP cord-274141-vujx538o 317 33 pro pro JJ cord-274141-vujx538o 317 34 with with IN cord-274141-vujx538o 317 35 IC IC NNP cord-274141-vujx538o 317 36 50 50 CD cord-274141-vujx538o 317 37 values value NNS cord-274141-vujx538o 317 38 ranging range VBG cord-274141-vujx538o 317 39 from from IN cord-274141-vujx538o 317 40 2.7 2.7 CD cord-274141-vujx538o 317 41 to to IN cord-274141-vujx538o 317 42 164.7 164.7 CD cord-274141-vujx538o 317 43 μM μm NN cord-274141-vujx538o 317 44 . . . cord-274141-vujx538o 318 1 Dieckol Dieckol NNP cord-274141-vujx538o 318 2 showed show VBD cord-274141-vujx538o 318 3 the the DT cord-274141-vujx538o 318 4 most most RBS cord-274141-vujx538o 318 5 potent potent JJ cord-274141-vujx538o 318 6 SARS SARS NNP cord-274141-vujx538o 318 7 - - HYPH cord-274141-vujx538o 318 8 CoV CoV NNP cord-274141-vujx538o 318 9 3CL 3CL NNP cord-274141-vujx538o 318 10 pro pro JJ cord-274141-vujx538o 318 11 trans trans NNP cord-274141-vujx538o 318 12 / / SYM cord-274141-vujx538o 318 13 cis cis NNP cord-274141-vujx538o 318 14 - - HYPH cord-274141-vujx538o 318 15 cleavage cleavage JJ cord-274141-vujx538o 318 16 inhibitory inhibitory JJ cord-274141-vujx538o 318 17 effects effect NNS cord-274141-vujx538o 318 18 . . . cord-274141-vujx538o 319 1 Isolated isolate VBN cord-274141-vujx538o 319 2 from from IN cord-274141-vujx538o 319 3 the the DT cord-274141-vujx538o 319 4 marine marine JJ cord-274141-vujx538o 319 5 alga alga NN cord-274141-vujx538o 319 6 Halimeda Halimeda NNP cord-274141-vujx538o 319 7 tuna tuna NN cord-274141-vujx538o 319 8 ( ( -LRB- cord-274141-vujx538o 319 9 J.Ellis J.Ellis NNP cord-274141-vujx538o 319 10 & & CC cord-274141-vujx538o 319 11 Solander Solander NNP cord-274141-vujx538o 319 12 ) ) -RRB- cord-274141-vujx538o 319 13 J.V.Lamouroux J.V.Lamouroux NNP cord-274141-vujx538o 319 14 , , , cord-274141-vujx538o 319 15 halitunal halitunal NNP cord-274141-vujx538o 319 16 is be VBZ cord-274141-vujx538o 319 17 a a DT cord-274141-vujx538o 319 18 novel novel NN cord-274141-vujx538o 319 19 diterpene diterpene IN cord-274141-vujx538o 319 20 aldehyde aldehyde NN cord-274141-vujx538o 319 21 with with IN cord-274141-vujx538o 319 22 a a DT cord-274141-vujx538o 319 23 unique unique JJ cord-274141-vujx538o 319 24 cyclopentadieno[c]pyran cyclopentadieno[c]pyran JJ cord-274141-vujx538o 319 25 ring ring NN cord-274141-vujx538o 319 26 system system NN cord-274141-vujx538o 319 27 . . . cord-274141-vujx538o 320 1 Halitunal Halitunal NNP cord-274141-vujx538o 320 2 displayed display VBD cord-274141-vujx538o 320 3 antiviral antiviral JJ cord-274141-vujx538o 320 4 activity activity NN cord-274141-vujx538o 320 5 against against IN cord-274141-vujx538o 320 6 murine murine JJ cord-274141-vujx538o 320 7 coronavirus coronavirus NN cord-274141-vujx538o 320 8 A59 a59 NN cord-274141-vujx538o 321 1 in in IN cord-274141-vujx538o 321 2 vitro vitro FW cord-274141-vujx538o 322 1 ( ( -LRB- cord-274141-vujx538o 322 2 Gustafson Gustafson NNP cord-274141-vujx538o 322 3 et et NNP cord-274141-vujx538o 322 4 al al NNP cord-274141-vujx538o 322 5 . . . cord-274141-vujx538o 322 6 2004 2004 CD cord-274141-vujx538o 322 7 ) ) -RRB- cord-274141-vujx538o 322 8 . . . cord-274141-vujx538o 323 1 Dercitin Dercitin NNP cord-274141-vujx538o 323 2 , , , cord-274141-vujx538o 323 3 an an DT cord-274141-vujx538o 323 4 acridine acridine NN cord-274141-vujx538o 323 5 alkaloid alkaloid NN cord-274141-vujx538o 323 6 isolated isolate VBN cord-274141-vujx538o 323 7 from from IN cord-274141-vujx538o 323 8 a a DT cord-274141-vujx538o 323 9 marine marine JJ cord-274141-vujx538o 323 10 sponge sponge NN cord-274141-vujx538o 323 11 in in IN cord-274141-vujx538o 323 12 the the DT cord-274141-vujx538o 323 13 genus genus NN cord-274141-vujx538o 323 14 Dercitus Dercitus NNP cord-274141-vujx538o 323 15 Gray Gray NNP cord-274141-vujx538o 323 16 , , , cord-274141-vujx538o 323 17 inhibited inhibit VBD cord-274141-vujx538o 323 18 the the DT cord-274141-vujx538o 323 19 coronavirus coronavirus NN cord-274141-vujx538o 323 20 A59 A59 NNP cord-274141-vujx538o 323 21 strain strain NN cord-274141-vujx538o 323 22 ( ( -LRB- cord-274141-vujx538o 323 23 EC EC NNP cord-274141-vujx538o 323 24 50 50 CD cord-274141-vujx538o 323 25 1.8 1.8 CD cord-274141-vujx538o 323 26 μM μm CD cord-274141-vujx538o 323 27 ) ) -RRB- cord-274141-vujx538o 323 28 . . . cord-274141-vujx538o 324 1 Mycalamides mycalamide NNS cord-274141-vujx538o 324 2 A A NNP cord-274141-vujx538o 324 3 and and CC cord-274141-vujx538o 324 4 B b NN cord-274141-vujx538o 324 5 , , , cord-274141-vujx538o 324 6 protein protein NN cord-274141-vujx538o 324 7 synthesis synthesis NN cord-274141-vujx538o 324 8 inhibitors inhibitor NNS cord-274141-vujx538o 324 9 and and CC cord-274141-vujx538o 324 10 antiviral antiviral JJ cord-274141-vujx538o 324 11 compounds compound NNS cord-274141-vujx538o 324 12 isolated isolate VBN cord-274141-vujx538o 324 13 from from IN cord-274141-vujx538o 324 14 a a DT cord-274141-vujx538o 324 15 sponge sponge NN cord-274141-vujx538o 324 16 Mycale Mycale NNP cord-274141-vujx538o 324 17 incrustans incrustans NNPS cord-274141-vujx538o 324 18 Burton Burton NNP cord-274141-vujx538o 324 19 , , , cord-274141-vujx538o 324 20 also also RB cord-274141-vujx538o 324 21 inhibited inhibit VBD cord-274141-vujx538o 324 22 coronavirus coronavirus NN cord-274141-vujx538o 324 23 A59 A59 NNP cord-274141-vujx538o 324 24 ( ( -LRB- cord-274141-vujx538o 324 25 Laport Laport NNP cord-274141-vujx538o 324 26 et et NNP cord-274141-vujx538o 324 27 al al NNP cord-274141-vujx538o 324 28 . . NNP cord-274141-vujx538o 324 29 2009 2009 CD cord-274141-vujx538o 324 30 ) ) -RRB- cord-274141-vujx538o 324 31 . . . cord-274141-vujx538o 325 1 In in IN cord-274141-vujx538o 325 2 vivo vivo NN cord-274141-vujx538o 325 3 activity activity NN cord-274141-vujx538o 325 4 against against IN cord-274141-vujx538o 325 5 coronavirus coronavirus NN cord-274141-vujx538o 325 6 A59 A59 NNP cord-274141-vujx538o 325 7 was be VBD cord-274141-vujx538o 325 8 observed observe VBN cord-274141-vujx538o 325 9 in in IN cord-274141-vujx538o 325 10 mice mouse NNS cord-274141-vujx538o 325 11 treated treat VBN cord-274141-vujx538o 325 12 with with IN cord-274141-vujx538o 325 13 a a DT cord-274141-vujx538o 325 14 2 2 CD cord-274141-vujx538o 325 15 % % NN cord-274141-vujx538o 325 16 mycalamide mycalamide NN cord-274141-vujx538o 325 17 mixture mixture NN cord-274141-vujx538o 325 18 at at IN cord-274141-vujx538o 325 19 a a DT cord-274141-vujx538o 325 20 dosage dosage NN cord-274141-vujx538o 325 21 of of IN cord-274141-vujx538o 325 22 0.2 0.2 CD cord-274141-vujx538o 325 23 μg μg NNS cord-274141-vujx538o 325 24 / / SYM cord-274141-vujx538o 325 25 kg kg NNP cord-274141-vujx538o 325 26 daily daily RB cord-274141-vujx538o 325 27 with with IN cord-274141-vujx538o 325 28 100 100 CD cord-274141-vujx538o 325 29 % % NN cord-274141-vujx538o 325 30 survival survival NN cord-274141-vujx538o 325 31 over over IN cord-274141-vujx538o 325 32 a a DT cord-274141-vujx538o 325 33 2-week 2-week CD cord-274141-vujx538o 325 34 period period NN cord-274141-vujx538o 325 35 ( ( -LRB- cord-274141-vujx538o 325 36 Gallimore Gallimore NNP cord-274141-vujx538o 325 37 2017 2017 CD cord-274141-vujx538o 325 38 ) ) -RRB- cord-274141-vujx538o 325 39 . . . cord-274141-vujx538o 326 1 Triterpenes Triterpenes NNP cord-274141-vujx538o 326 2 ( ( -LRB- cord-274141-vujx538o 326 3 thyrsiferol thyrsiferol NNP cord-274141-vujx538o 326 4 , , , cord-274141-vujx538o 326 5 thyrsiferol thyrsiferol JJ cord-274141-vujx538o 326 6 acetate acetate NN cord-274141-vujx538o 326 7 , , , cord-274141-vujx538o 326 8 venustatriol venustatriol NNP cord-274141-vujx538o 326 9 ) ) -RRB- cord-274141-vujx538o 326 10 isolated isolate VBN cord-274141-vujx538o 326 11 from from IN cord-274141-vujx538o 326 12 the the DT cord-274141-vujx538o 326 13 red red JJ cord-274141-vujx538o 326 14 alga alga NN cord-274141-vujx538o 326 15 Laurencia Laurencia NNP cord-274141-vujx538o 326 16 venusta venusta . cord-274141-vujx538o 326 17 Yamada Yamada NNP cord-274141-vujx538o 326 18 inhibit inhibit VB cord-274141-vujx538o 326 19 coronaviruses coronaviruse NNS cord-274141-vujx538o 326 20 , , , cord-274141-vujx538o 326 21 and and CC cord-274141-vujx538o 326 22 orthosterol orthosterol NNP cord-274141-vujx538o 326 23 disodium disodium NN cord-274141-vujx538o 326 24 sulfates sulfate NNS cord-274141-vujx538o 326 25 from from IN cord-274141-vujx538o 326 26 the the DT cord-274141-vujx538o 326 27 sponge sponge NN cord-274141-vujx538o 327 1 Petrosia Petrosia NNP cord-274141-vujx538o 327 2 weinbergi weinbergi NNP cord-274141-vujx538o 327 3 Van Van NNP cord-274141-vujx538o 327 4 Soest Soest NNP cord-274141-vujx538o 327 5 inhibit inhibit VBP cord-274141-vujx538o 327 6 coronavirus coronavirus NN cord-274141-vujx538o 327 7 A59 A59 NNP cord-274141-vujx538o 327 8 ( ( -LRB- cord-274141-vujx538o 327 9 El El NNP cord-274141-vujx538o 327 10 Sayed Sayed NNP cord-274141-vujx538o 327 11 2000 2000 CD cord-274141-vujx538o 327 12 ) ) -RRB- cord-274141-vujx538o 327 13 . . . cord-274141-vujx538o 328 1 Spirulina Spirulina NNP cord-274141-vujx538o 328 2 platensis platensis NN cord-274141-vujx538o 328 3 ( ( -LRB- cord-274141-vujx538o 328 4 Gomont Gomont NNP cord-274141-vujx538o 328 5 ) ) -RRB- cord-274141-vujx538o 328 6 Geitler Geitler NNP cord-274141-vujx538o 328 7 is be VBZ cord-274141-vujx538o 328 8 a a DT cord-274141-vujx538o 328 9 microscopic microscopic JJ cord-274141-vujx538o 328 10 filamentous filamentous JJ cord-274141-vujx538o 328 11 alga alga NN cord-274141-vujx538o 328 12 rich rich JJ cord-274141-vujx538o 328 13 in in IN cord-274141-vujx538o 328 14 proteins protein NNS cord-274141-vujx538o 328 15 , , , cord-274141-vujx538o 328 16 vitamins vitamin NNS cord-274141-vujx538o 328 17 , , , cord-274141-vujx538o 328 18 essential essential JJ cord-274141-vujx538o 328 19 amino amino NN cord-274141-vujx538o 328 20 acids acid NNS cord-274141-vujx538o 328 21 , , , cord-274141-vujx538o 328 22 minerals mineral NNS cord-274141-vujx538o 328 23 , , , cord-274141-vujx538o 328 24 and and CC cord-274141-vujx538o 328 25 essential essential JJ cord-274141-vujx538o 328 26 fatty fatty JJ cord-274141-vujx538o 328 27 acids acid NNS cord-274141-vujx538o 328 28 like like IN cord-274141-vujx538o 328 29 γ γ NN cord-274141-vujx538o 328 30 - - HYPH cord-274141-vujx538o 328 31 linolenic linolenic JJ cord-274141-vujx538o 328 32 acid acid NN cord-274141-vujx538o 328 33 . . . cord-274141-vujx538o 329 1 It -PRON- PRP cord-274141-vujx538o 329 2 is be VBZ cord-274141-vujx538o 329 3 produced produce VBN cord-274141-vujx538o 329 4 commercially commercially RB cord-274141-vujx538o 329 5 and and CC cord-274141-vujx538o 329 6 sold sell VBN cord-274141-vujx538o 329 7 as as IN cord-274141-vujx538o 329 8 a a DT cord-274141-vujx538o 329 9 food food NN cord-274141-vujx538o 329 10 supplement supplement NN cord-274141-vujx538o 329 11 in in IN cord-274141-vujx538o 329 12 health health NN cord-274141-vujx538o 329 13 food food NN cord-274141-vujx538o 329 14 stores store NNS cord-274141-vujx538o 329 15 around around IN cord-274141-vujx538o 329 16 the the DT cord-274141-vujx538o 329 17 world world NN cord-274141-vujx538o 329 18 . . . cord-274141-vujx538o 330 1 Spirulina Spirulina NNP cord-274141-vujx538o 330 2 platensis platensis NNP cord-274141-vujx538o 330 3 ( ( -LRB- cord-274141-vujx538o 330 4 15 15 CD cord-274141-vujx538o 330 5 g g NN cord-274141-vujx538o 330 6 ) ) -RRB- cord-274141-vujx538o 330 7 enhances enhance VBZ cord-274141-vujx538o 330 8 the the DT cord-274141-vujx538o 330 9 immune immune JJ cord-274141-vujx538o 330 10 status status NN cord-274141-vujx538o 330 11 and and CC cord-274141-vujx538o 330 12 inflammatory inflammatory JJ cord-274141-vujx538o 330 13 and and CC cord-274141-vujx538o 330 14 oxidative oxidative JJ cord-274141-vujx538o 330 15 markers marker NNS cord-274141-vujx538o 330 16 of of IN cord-274141-vujx538o 330 17 COVID-19 covid-19 JJ cord-274141-vujx538o 330 18 patients patient NNS cord-274141-vujx538o 330 19 ( ( -LRB- cord-274141-vujx538o 330 20 McCarty McCarty NNP cord-274141-vujx538o 330 21 and and CC cord-274141-vujx538o 330 22 DiNicolantonio DiNicolantonio NNP cord-274141-vujx538o 330 23 2020 2020 CD cord-274141-vujx538o 330 24 ) ) -RRB- cord-274141-vujx538o 330 25 . . . cord-274141-vujx538o 331 1 China China NNP cord-274141-vujx538o 331 2 Xiao Xiao NNP cord-274141-vujx538o 331 3 et et NNP cord-274141-vujx538o 331 4 al al NNP cord-274141-vujx538o 331 5 . . . cord-274141-vujx538o 332 1 ( ( -LRB- cord-274141-vujx538o 332 2 2003 2003 CD cord-274141-vujx538o 332 3 ) ) -RRB- cord-274141-vujx538o 332 4 provided provide VBD cord-274141-vujx538o 332 5 leading lead VBG cord-274141-vujx538o 332 6 insights insight NNS cord-274141-vujx538o 332 7 into into IN cord-274141-vujx538o 332 8 the the DT cord-274141-vujx538o 332 9 use use NN cord-274141-vujx538o 332 10 of of IN cord-274141-vujx538o 332 11 fourteen fourteen CD cord-274141-vujx538o 332 12 Chinese chinese JJ cord-274141-vujx538o 332 13 herbal herbal JJ cord-274141-vujx538o 332 14 medicines medicine NNS cord-274141-vujx538o 332 15 in in IN cord-274141-vujx538o 332 16 the the DT cord-274141-vujx538o 332 17 prevention prevention NN cord-274141-vujx538o 332 18 and and CC cord-274141-vujx538o 332 19 treatment treatment NN cord-274141-vujx538o 332 20 of of IN cord-274141-vujx538o 332 21 SARS SARS NNP cord-274141-vujx538o 332 22 . . . cord-274141-vujx538o 333 1 TCM TCM NNP cord-274141-vujx538o 333 2 played play VBD cord-274141-vujx538o 333 3 an an DT cord-274141-vujx538o 333 4 important important JJ cord-274141-vujx538o 333 5 role role NN cord-274141-vujx538o 333 6 in in IN cord-274141-vujx538o 333 7 the the DT cord-274141-vujx538o 333 8 fight fight NN cord-274141-vujx538o 333 9 against against IN cord-274141-vujx538o 333 10 SARS SARS NNP cord-274141-vujx538o 333 11 and and CC cord-274141-vujx538o 333 12 it -PRON- PRP cord-274141-vujx538o 333 13 was be VBD cord-274141-vujx538o 333 14 reported report VBN cord-274141-vujx538o 333 15 by by IN cord-274141-vujx538o 333 16 practitioners practitioner NNS cord-274141-vujx538o 333 17 to to TO cord-274141-vujx538o 333 18 be be VB cord-274141-vujx538o 333 19 very very RB cord-274141-vujx538o 333 20 effective effective JJ cord-274141-vujx538o 334 1 ( ( -LRB- cord-274141-vujx538o 334 2 Lau Lau NNP cord-274141-vujx538o 334 3 et et NNP cord-274141-vujx538o 334 4 al al NNP cord-274141-vujx538o 334 5 . . NNP cord-274141-vujx538o 334 6 2005 2005 CD cord-274141-vujx538o 334 7 ) ) -RRB- cord-274141-vujx538o 334 8 . . . cord-274141-vujx538o 335 1 The the DT cord-274141-vujx538o 335 2 State State NNP cord-274141-vujx538o 335 3 Administration Administration NNP cord-274141-vujx538o 335 4 of of IN cord-274141-vujx538o 335 5 TCM TCM NNP cord-274141-vujx538o 335 6 of of IN cord-274141-vujx538o 335 7 the the DT cord-274141-vujx538o 335 8 People People NNPS cord-274141-vujx538o 335 9 's 's POS cord-274141-vujx538o 335 10 Republic Republic NNP cord-274141-vujx538o 335 11 of of IN cord-274141-vujx538o 335 12 China China NNP cord-274141-vujx538o 335 13 formed form VBD cord-274141-vujx538o 335 14 a a DT cord-274141-vujx538o 335 15 panel panel NN cord-274141-vujx538o 335 16 of of IN cord-274141-vujx538o 335 17 TCM TCM NNP cord-274141-vujx538o 335 18 specialists specialist NNS cord-274141-vujx538o 335 19 to to TO cord-274141-vujx538o 335 20 draw draw VB cord-274141-vujx538o 335 21 up up RP cord-274141-vujx538o 335 22 a a DT cord-274141-vujx538o 335 23 technical technical JJ cord-274141-vujx538o 335 24 scheme scheme NN cord-274141-vujx538o 335 25 for for IN cord-274141-vujx538o 335 26 the the DT cord-274141-vujx538o 335 27 prevention prevention NN cord-274141-vujx538o 335 28 and and CC cord-274141-vujx538o 335 29 treatment treatment NN cord-274141-vujx538o 335 30 of of IN cord-274141-vujx538o 335 31 SARS SARS NNP cord-274141-vujx538o 335 32 - - HYPH cord-274141-vujx538o 335 33 CoV CoV NNP cord-274141-vujx538o 335 34 using use VBG cord-274141-vujx538o 335 35 TCM TCM NNP cord-274141-vujx538o 335 36 . . . cord-274141-vujx538o 336 1 Scutellaria Scutellaria NNP cord-274141-vujx538o 336 2 baicalensis baicalensis NNP cord-274141-vujx538o 336 3 is be VBZ cord-274141-vujx538o 336 4 one one CD cord-274141-vujx538o 336 5 of of IN cord-274141-vujx538o 336 6 the the DT cord-274141-vujx538o 336 7 most most RBS cord-274141-vujx538o 336 8 widely widely RB cord-274141-vujx538o 336 9 used use VBN cord-274141-vujx538o 336 10 TCMs tcm NNS cord-274141-vujx538o 336 11 and and CC cord-274141-vujx538o 336 12 its -PRON- PRP$ cord-274141-vujx538o 336 13 roots root NNS cord-274141-vujx538o 336 14 are be VBP cord-274141-vujx538o 336 15 used use VBN cord-274141-vujx538o 336 16 to to TO cord-274141-vujx538o 336 17 treat treat VB cord-274141-vujx538o 336 18 inflammation inflammation NN cord-274141-vujx538o 336 19 , , , cord-274141-vujx538o 336 20 cancer cancer NN cord-274141-vujx538o 336 21 , , , cord-274141-vujx538o 336 22 and and CC cord-274141-vujx538o 336 23 viral viral JJ cord-274141-vujx538o 336 24 and and CC cord-274141-vujx538o 336 25 bacterial bacterial JJ cord-274141-vujx538o 336 26 infections infection NNS cord-274141-vujx538o 336 27 . . . cord-274141-vujx538o 337 1 Baicalin Baicalin NNP cord-274141-vujx538o 337 2 , , , cord-274141-vujx538o 337 3 baicalein baicalein NNP cord-274141-vujx538o 337 4 , , , cord-274141-vujx538o 337 5 wogonin wogonin NNP cord-274141-vujx538o 337 6 , , , cord-274141-vujx538o 337 7 and and CC cord-274141-vujx538o 337 8 oroxylin oroxylin NNP cord-274141-vujx538o 338 1 A a DT cord-274141-vujx538o 338 2 are be VBP cord-274141-vujx538o 338 3 the the DT cord-274141-vujx538o 338 4 main main JJ cord-274141-vujx538o 338 5 active active JJ cord-274141-vujx538o 338 6 components component NNS cord-274141-vujx538o 338 7 in in IN cord-274141-vujx538o 338 8 S. S. NNP cord-274141-vujx538o 338 9 baicalensis baicalensis NN cord-274141-vujx538o 338 10 . . . cord-274141-vujx538o 339 1 The the DT cord-274141-vujx538o 339 2 most most RBS cord-274141-vujx538o 339 3 abundant abundant JJ cord-274141-vujx538o 339 4 active active JJ cord-274141-vujx538o 339 5 compound compound NN cord-274141-vujx538o 339 6 , , , cord-274141-vujx538o 339 7 baicalin baicalin NNP cord-274141-vujx538o 339 8 , , , cord-274141-vujx538o 339 9 exhibits exhibit VBZ cord-274141-vujx538o 339 10 anti anti JJ cord-274141-vujx538o 339 11 - - JJ cord-274141-vujx538o 339 12 SARS SARS NNP cord-274141-vujx538o 339 13 - - HYPH cord-274141-vujx538o 339 14 CoV CoV NNP cord-274141-vujx538o 339 15 properties property NNS cord-274141-vujx538o 339 16 . . . cord-274141-vujx538o 340 1 Yeh Yeh NNP cord-274141-vujx538o 340 2 et et NNP cord-274141-vujx538o 340 3 al al NNP cord-274141-vujx538o 340 4 . . . cord-274141-vujx538o 341 1 ( ( -LRB- cord-274141-vujx538o 341 2 2013 2013 CD cord-274141-vujx538o 341 3 ) ) -RRB- cord-274141-vujx538o 341 4 affirmed affirm VBD cord-274141-vujx538o 341 5 that that IN cord-274141-vujx538o 341 6 licorice licorice NN cord-274141-vujx538o 341 7 ( ( -LRB- cord-274141-vujx538o 341 8 Glycyrrhiza Glycyrrhiza NNP cord-274141-vujx538o 341 9 uralensis uralensis NN cord-274141-vujx538o 341 10 Fisch Fisch NNP cord-274141-vujx538o 341 11 . . . cord-274141-vujx538o 342 1 ex ex NNP cord-274141-vujx538o 342 2 DC DC NNP cord-274141-vujx538o 342 3 . . . cord-274141-vujx538o 342 4 ) ) -RRB- cord-274141-vujx538o 342 5 is be VBZ cord-274141-vujx538o 342 6 a a DT cord-274141-vujx538o 342 7 common common JJ cord-274141-vujx538o 342 8 ingredient ingredient NN cord-274141-vujx538o 342 9 in in IN cord-274141-vujx538o 342 10 prescriptions prescription NNS cord-274141-vujx538o 342 11 of of IN cord-274141-vujx538o 342 12 TCM TCM NNP cord-274141-vujx538o 342 13 . . . cord-274141-vujx538o 343 1 Licorice licorice NN cord-274141-vujx538o 343 2 has have VBZ cord-274141-vujx538o 343 3 antiviral antiviral JJ cord-274141-vujx538o 343 4 activity activity NN cord-274141-vujx538o 343 5 against against IN cord-274141-vujx538o 343 6 various various JJ cord-274141-vujx538o 343 7 DNA DNA NNP cord-274141-vujx538o 343 8 and and CC cord-274141-vujx538o 343 9 RNA RNA NNP cord-274141-vujx538o 343 10 viruses virus NNS cord-274141-vujx538o 343 11 including include VBG cord-274141-vujx538o 343 12 HIV HIV NNP cord-274141-vujx538o 343 13 and and CC cord-274141-vujx538o 343 14 SARS SARS NNP cord-274141-vujx538o 343 15 - - HYPH cord-274141-vujx538o 343 16 CoV. CoV. NNP cord-274141-vujx538o 344 1 Chinese chinese JJ cord-274141-vujx538o 344 2 multi multi JJ cord-274141-vujx538o 344 3 - - JJ cord-274141-vujx538o 344 4 plant plant JJ cord-274141-vujx538o 344 5 remedy remedy NN cord-274141-vujx538o 344 6 consisting consist VBG cord-274141-vujx538o 344 7 of of IN cord-274141-vujx538o 344 8 Houttuynia Houttuynia NNP cord-274141-vujx538o 344 9 cordata cordata NN cord-274141-vujx538o 344 10 Thunb Thunb NNP cord-274141-vujx538o 344 11 . . . cord-274141-vujx538o 345 1 , , , cord-274141-vujx538o 345 2 Chrysanthemum Chrysanthemum NNP cord-274141-vujx538o 345 3 morifolium morifolium NN cord-274141-vujx538o 345 4 Ramat Ramat NNP cord-274141-vujx538o 345 5 . . . cord-274141-vujx538o 346 1 , , , cord-274141-vujx538o 346 2 Artemisia Artemisia NNP cord-274141-vujx538o 346 3 scoparia scoparia NNP cord-274141-vujx538o 346 4 Waldst Waldst NNP cord-274141-vujx538o 346 5 . . . cord-274141-vujx538o 346 6 & & CC cord-274141-vujx538o 346 7 Kit Kit NNP cord-274141-vujx538o 346 8 . . . cord-274141-vujx538o 347 1 , , , cord-274141-vujx538o 347 2 Eupatorium Eupatorium NNP cord-274141-vujx538o 347 3 fortunei fortunei NNP cord-274141-vujx538o 347 4 Turcz Turcz NNP cord-274141-vujx538o 347 5 . . . cord-274141-vujx538o 347 6 , , , cord-274141-vujx538o 347 7 and and CC cord-274141-vujx538o 347 8 Amomum Amomum NNP cord-274141-vujx538o 347 9 tsao tsao NNP cord-274141-vujx538o 347 10 - - HYPH cord-274141-vujx538o 347 11 ko ko NNP cord-274141-vujx538o 347 12 Crevost Crevost NNP cord-274141-vujx538o 347 13 & & CC cord-274141-vujx538o 347 14 Lemarié Lemarié NNP cord-274141-vujx538o 347 15 was be VBD cord-274141-vujx538o 347 16 effective effective JJ cord-274141-vujx538o 347 17 in in IN cord-274141-vujx538o 347 18 the the DT cord-274141-vujx538o 347 19 prevention prevention NN cord-274141-vujx538o 347 20 and and CC cord-274141-vujx538o 347 21 treatment treatment NN cord-274141-vujx538o 347 22 of of IN cord-274141-vujx538o 347 23 SARS SARS NNP cord-274141-vujx538o 347 24 - - HYPH cord-274141-vujx538o 347 25 CoV CoV NNP cord-274141-vujx538o 347 26 ( ( -LRB- cord-274141-vujx538o 347 27 Zhang Zhang NNP cord-274141-vujx538o 347 28 and and CC cord-274141-vujx538o 347 29 Chen Chen NNP cord-274141-vujx538o 347 30 2008 2008 CD cord-274141-vujx538o 347 31 ) ) -RRB- cord-274141-vujx538o 347 32 . . . cord-274141-vujx538o 348 1 Extracts extract NNS cord-274141-vujx538o 348 2 of of IN cord-274141-vujx538o 348 3 Lonicera Lonicera NNP cord-274141-vujx538o 348 4 japonica japonica NN cord-274141-vujx538o 348 5 are be VBP cord-274141-vujx538o 348 6 a a DT cord-274141-vujx538o 348 7 common common JJ cord-274141-vujx538o 348 8 TCM TCM NNP cord-274141-vujx538o 348 9 used use VBN cord-274141-vujx538o 348 10 to to TO cord-274141-vujx538o 348 11 treat treat VB cord-274141-vujx538o 348 12 SARS SARS NNP cord-274141-vujx538o 348 13 - - HYPH cord-274141-vujx538o 348 14 CoV CoV NNP cord-274141-vujx538o 348 15 ( ( -LRB- cord-274141-vujx538o 348 16 Wang Wang NNP cord-274141-vujx538o 348 17 et et NNP cord-274141-vujx538o 348 18 al al NNP cord-274141-vujx538o 348 19 . . NNP cord-274141-vujx538o 348 20 2014 2014 CD cord-274141-vujx538o 348 21 ) ) -RRB- cord-274141-vujx538o 348 22 . . . cord-274141-vujx538o 349 1 To to TO cord-274141-vujx538o 349 2 control control VB cord-274141-vujx538o 349 3 SARS SARS NNP cord-274141-vujx538o 349 4 - - HYPH cord-274141-vujx538o 349 5 CoV CoV NNP cord-274141-vujx538o 349 6 in in IN cord-274141-vujx538o 349 7 2003 2003 CD cord-274141-vujx538o 349 8 , , , cord-274141-vujx538o 349 9 L. L. NNP cord-274141-vujx538o 349 10 japonica japonica NNP cord-274141-vujx538o 349 11 was be VBD cord-274141-vujx538o 349 12 widely widely RB cord-274141-vujx538o 349 13 used use VBN cord-274141-vujx538o 349 14 in in IN cord-274141-vujx538o 349 15 prescriptions prescription NNS cord-274141-vujx538o 349 16 publicly publicly RB cord-274141-vujx538o 349 17 published publish VBN cord-274141-vujx538o 349 18 by by IN cord-274141-vujx538o 349 19 the the DT cord-274141-vujx538o 349 20 State State NNP cord-274141-vujx538o 349 21 Administration Administration NNP cord-274141-vujx538o 349 22 of of IN cord-274141-vujx538o 349 23 TCM TCM NNP cord-274141-vujx538o 349 24 . . . cord-274141-vujx538o 350 1 Panax Panax NNP cord-274141-vujx538o 350 2 ginseng ginseng NN cord-274141-vujx538o 350 3 C.A.Mey C.A.Mey NNP cord-274141-vujx538o 350 4 . . . cord-274141-vujx538o 350 5 , , , cord-274141-vujx538o 350 6 commonly commonly RB cord-274141-vujx538o 350 7 known know VBN cord-274141-vujx538o 350 8 as as IN cord-274141-vujx538o 350 9 ginseng ginseng NN cord-274141-vujx538o 350 10 , , , cord-274141-vujx538o 350 11 is be VBZ cord-274141-vujx538o 350 12 a a DT cord-274141-vujx538o 350 13 known know VBN cord-274141-vujx538o 350 14 natural natural JJ cord-274141-vujx538o 350 15 antiviral antiviral JJ cord-274141-vujx538o 350 16 agent agent NN cord-274141-vujx538o 350 17 with with IN cord-274141-vujx538o 350 18 protective protective JJ cord-274141-vujx538o 350 19 effects effect NNS cord-274141-vujx538o 350 20 against against IN cord-274141-vujx538o 350 21 SARS SARS NNP cord-274141-vujx538o 350 22 - - HYPH cord-274141-vujx538o 350 23 CoV CoV NNP cord-274141-vujx538o 350 24 ( ( -LRB- cord-274141-vujx538o 350 25 I -PRON- PRP cord-274141-vujx538o 350 26 m be VBP cord-274141-vujx538o 350 27 et et NNP cord-274141-vujx538o 350 28 al al NNP cord-274141-vujx538o 350 29 . . . cord-274141-vujx538o 350 30 2016 2016 CD cord-274141-vujx538o 350 31 ) ) -RRB- cord-274141-vujx538o 350 32 . . . cord-274141-vujx538o 351 1 Extracts extract NNS cord-274141-vujx538o 351 2 of of IN cord-274141-vujx538o 351 3 T. t. NN cord-274141-vujx538o 351 4 sinensis sinensis NN cord-274141-vujx538o 351 5 inhibit inhibit VBP cord-274141-vujx538o 351 6 SARS SARS NNP cord-274141-vujx538o 351 7 - - HYPH cord-274141-vujx538o 351 8 CoV CoV NNP cord-274141-vujx538o 351 9 replication replication NN cord-274141-vujx538o 351 10 Wu Wu NNP cord-274141-vujx538o 351 11 et et NNP cord-274141-vujx538o 351 12 al al NNP cord-274141-vujx538o 351 13 . . NNP cord-274141-vujx538o 351 14 2014 2014 CD cord-274141-vujx538o 351 15 ) ) -RRB- cord-274141-vujx538o 351 16 . . . cord-274141-vujx538o 352 1 Extracts extract NNS cord-274141-vujx538o 352 2 of of IN cord-274141-vujx538o 352 3 plants plant NNS cord-274141-vujx538o 352 4 Lycoris Lycoris NNP cord-274141-vujx538o 352 5 radiata radiata NN cord-274141-vujx538o 352 6 Miq Miq NNP cord-274141-vujx538o 352 7 . . NNP cord-274141-vujx538o 352 8 , , , cord-274141-vujx538o 352 9 Artemisia Artemisia NNP cord-274141-vujx538o 352 10 annua annua NN cord-274141-vujx538o 352 11 L. L. NNP cord-274141-vujx538o 352 12 , , , cord-274141-vujx538o 352 13 Pyrrosia Pyrrosia NNP cord-274141-vujx538o 352 14 lingua lingua NN cord-274141-vujx538o 352 15 ( ( -LRB- cord-274141-vujx538o 352 16 Thunb Thunb NNP cord-274141-vujx538o 352 17 . . . cord-274141-vujx538o 352 18 ) ) -RRB- cord-274141-vujx538o 353 1 Farw Farw NNP cord-274141-vujx538o 353 2 . . . cord-274141-vujx538o 354 1 , , , cord-274141-vujx538o 354 2 and and CC cord-274141-vujx538o 354 3 Lindera Lindera NNP cord-274141-vujx538o 354 4 aggregata aggregata NN cord-274141-vujx538o 354 5 ( ( -LRB- cord-274141-vujx538o 354 6 Sims Sims NNP cord-274141-vujx538o 354 7 ) ) -RRB- cord-274141-vujx538o 354 8 Kosterm Kosterm NNP cord-274141-vujx538o 354 9 . . . cord-274141-vujx538o 354 10 displayed display VBD cord-274141-vujx538o 354 11 anti anti JJ cord-274141-vujx538o 354 12 - - JJ cord-274141-vujx538o 354 13 SARS SARS NNP cord-274141-vujx538o 354 14 - - HYPH cord-274141-vujx538o 354 15 CoV CoV NNP cord-274141-vujx538o 354 16 actions action NNS cord-274141-vujx538o 354 17 with with IN cord-274141-vujx538o 354 18 EC EC NNP cord-274141-vujx538o 354 19 50 50 CD cord-274141-vujx538o 354 20 values value NNS cord-274141-vujx538o 354 21 of of IN cord-274141-vujx538o 354 22 2.4 2.4 CD cord-274141-vujx538o 354 23 ± ± NNP cord-274141-vujx538o 354 24 0.2 0.2 CD cord-274141-vujx538o 354 25 , , , cord-274141-vujx538o 354 26 34.5 34.5 CD cord-274141-vujx538o 354 27 ± ± CD cord-274141-vujx538o 354 28 2.6 2.6 CD cord-274141-vujx538o 354 29 , , , cord-274141-vujx538o 354 30 43.2 43.2 CD cord-274141-vujx538o 354 31 ± ± CD cord-274141-vujx538o 354 32 14.1 14.1 CD cord-274141-vujx538o 354 33 , , , cord-274141-vujx538o 354 34 and and CC cord-274141-vujx538o 354 35 88.2 88.2 CD cord-274141-vujx538o 354 36 ± ± CD cord-274141-vujx538o 354 37 7.7 7.7 CD cord-274141-vujx538o 354 38 μg μg NNP cord-274141-vujx538o 354 39 / / SYM cord-274141-vujx538o 354 40 ml ml NNS cord-274141-vujx538o 354 41 , , , cord-274141-vujx538o 354 42 respectively respectively RB cord-274141-vujx538o 355 1 ( ( -LRB- cord-274141-vujx538o 355 2 Li Li NNP cord-274141-vujx538o 355 3 et et NNP cord-274141-vujx538o 355 4 al al NNP cord-274141-vujx538o 355 5 . . NNP cord-274141-vujx538o 355 6 2005 2005 CD cord-274141-vujx538o 355 7 ) ) -RRB- cord-274141-vujx538o 355 8 . . . cord-274141-vujx538o 356 1 An an DT cord-274141-vujx538o 356 2 ethanol ethanol NN cord-274141-vujx538o 356 3 stem stem NN cord-274141-vujx538o 356 4 cortex cortex NN cord-274141-vujx538o 356 5 extract extract NN cord-274141-vujx538o 356 6 of of IN cord-274141-vujx538o 356 7 L. L. NNP cord-274141-vujx538o 356 8 radiata radiata NN cord-274141-vujx538o 356 9 was be VBD cord-274141-vujx538o 356 10 very very RB cord-274141-vujx538o 356 11 potent potent JJ cord-274141-vujx538o 356 12 against against IN cord-274141-vujx538o 356 13 SARS SARS NNP cord-274141-vujx538o 356 14 - - HYPH cord-274141-vujx538o 356 15 CoV CoV NNP cord-274141-vujx538o 356 16 ( ( -LRB- cord-274141-vujx538o 356 17 EC EC NNP cord-274141-vujx538o 356 18 50 50 CD cord-274141-vujx538o 356 19 of of IN cord-274141-vujx538o 356 20 2.1 2.1 CD cord-274141-vujx538o 356 21 ± ± CD cord-274141-vujx538o 356 22 0.2 0.2 CD cord-274141-vujx538o 356 23 nm nm NN cord-274141-vujx538o 356 24 against against IN cord-274141-vujx538o 356 25 the the DT cord-274141-vujx538o 356 26 BJ-006 BJ-006 NNP cord-274141-vujx538o 356 27 viral viral JJ cord-274141-vujx538o 356 28 strain strain NN cord-274141-vujx538o 356 29 ) ) -RRB- cord-274141-vujx538o 357 1 ( ( -LRB- cord-274141-vujx538o 357 2 Li Li NNP cord-274141-vujx538o 357 3 et et NNP cord-274141-vujx538o 357 4 al al NNP cord-274141-vujx538o 357 5 . . NNP cord-274141-vujx538o 357 6 2005 2005 CD cord-274141-vujx538o 357 7 ) ) -RRB- cord-274141-vujx538o 357 8 . . . cord-274141-vujx538o 358 1 The the DT cord-274141-vujx538o 358 2 active active JJ cord-274141-vujx538o 358 3 compound compound NN cord-274141-vujx538o 358 4 lycorine lycorine NN cord-274141-vujx538o 358 5 was be VBD cord-274141-vujx538o 358 6 identified identify VBN cord-274141-vujx538o 358 7 as as IN cord-274141-vujx538o 358 8 the the DT cord-274141-vujx538o 358 9 anti anti JJ cord-274141-vujx538o 358 10 - - JJ cord-274141-vujx538o 358 11 SARS SARS NNP cord-274141-vujx538o 358 12 - - HYPH cord-274141-vujx538o 358 13 CoV CoV NNP cord-274141-vujx538o 358 14 component component NN cord-274141-vujx538o 358 15 ( ( -LRB- cord-274141-vujx538o 358 16 EC EC NNP cord-274141-vujx538o 358 17 50 50 CD cord-274141-vujx538o 358 18 value value NN cord-274141-vujx538o 358 19 of of IN cord-274141-vujx538o 358 20 15.7 15.7 CD cord-274141-vujx538o 358 21 ± ± CD cord-274141-vujx538o 358 22 1.2 1.2 CD cord-274141-vujx538o 358 23 nM nm NN cord-274141-vujx538o 358 24 ) ) -RRB- cord-274141-vujx538o 358 25 . . . cord-274141-vujx538o 359 1 Lycorine Lycorine NNP cord-274141-vujx538o 359 2 shows show VBZ cord-274141-vujx538o 359 3 moderate moderate JJ cord-274141-vujx538o 359 4 to to IN cord-274141-vujx538o 359 5 potent potent JJ cord-274141-vujx538o 359 6 antiviral antiviral JJ cord-274141-vujx538o 359 7 activity activity NN cord-274141-vujx538o 359 8 and and CC cord-274141-vujx538o 359 9 reduces reduce VBZ cord-274141-vujx538o 359 10 viral viral JJ cord-274141-vujx538o 359 11 titers titer NNS cord-274141-vujx538o 359 12 of of IN cord-274141-vujx538o 359 13 SARS SARS NNP cord-274141-vujx538o 359 14 - - HYPH cord-274141-vujx538o 359 15 CoV CoV NNP cord-274141-vujx538o 359 16 ( ( -LRB- cord-274141-vujx538o 359 17 Roy Roy NNP cord-274141-vujx538o 359 18 et et NNP cord-274141-vujx538o 359 19 al al NNP cord-274141-vujx538o 359 20 . . . cord-274141-vujx538o 359 21 2018 2018 CD cord-274141-vujx538o 359 22 ) ) -RRB- cord-274141-vujx538o 359 23 . . . cord-274141-vujx538o 360 1 Jinchai Jinchai NNP cord-274141-vujx538o 360 2 is be VBZ cord-274141-vujx538o 360 3 a a DT cord-274141-vujx538o 360 4 widely widely RB cord-274141-vujx538o 360 5 used use VBN cord-274141-vujx538o 360 6 TCM TCM NNP cord-274141-vujx538o 360 7 that that WDT cord-274141-vujx538o 360 8 deters deter VBZ cord-274141-vujx538o 360 9 SARS SARS NNP cord-274141-vujx538o 360 10 - - HYPH cord-274141-vujx538o 360 11 CoV CoV NNP cord-274141-vujx538o 360 12 entry entry NN cord-274141-vujx538o 360 13 , , , cord-274141-vujx538o 360 14 replication replication NN cord-274141-vujx538o 360 15 , , , cord-274141-vujx538o 360 16 and and CC cord-274141-vujx538o 360 17 lung lung NN cord-274141-vujx538o 360 18 inflammation inflammation NN cord-274141-vujx538o 360 19 induced induce VBN cord-274141-vujx538o 360 20 by by IN cord-274141-vujx538o 360 21 viral viral JJ cord-274141-vujx538o 360 22 infection infection NN cord-274141-vujx538o 360 23 ( ( -LRB- cord-274141-vujx538o 360 24 Zhong Zhong NNP cord-274141-vujx538o 360 25 et et FW cord-274141-vujx538o 360 26 al al NNP cord-274141-vujx538o 360 27 . . NNP cord-274141-vujx538o 360 28 2013 2013 CD cord-274141-vujx538o 360 29 ) ) -RRB- cord-274141-vujx538o 360 30 . . . cord-274141-vujx538o 361 1 Roots root NNS cord-274141-vujx538o 361 2 and and CC cord-274141-vujx538o 361 3 rhizomes rhizome NNS cord-274141-vujx538o 361 4 of of IN cord-274141-vujx538o 361 5 Glycyrrhiza Glycyrrhiza NNP cord-274141-vujx538o 361 6 glabra glabra NNP cord-274141-vujx538o 361 7 , , , cord-274141-vujx538o 361 8 a a DT cord-274141-vujx538o 361 9 natural natural JJ cord-274141-vujx538o 361 10 sweetener sweetener NN cord-274141-vujx538o 361 11 that that WDT cord-274141-vujx538o 361 12 contains contain VBZ cord-274141-vujx538o 361 13 glycyrrhizin glycyrrhizin NNS cord-274141-vujx538o 361 14 , , , cord-274141-vujx538o 361 15 inhibit inhibit VBP cord-274141-vujx538o 361 16 virus virus NN cord-274141-vujx538o 361 17 growth growth NN cord-274141-vujx538o 361 18 and and CC cord-274141-vujx538o 361 19 inactivate inactivate VBP cord-274141-vujx538o 361 20 virus virus NN cord-274141-vujx538o 361 21 particles particle NNS cord-274141-vujx538o 361 22 . . . cord-274141-vujx538o 362 1 Glycyrrhizic glycyrrhizic JJ cord-274141-vujx538o 362 2 acid acid NN cord-274141-vujx538o 362 3 , , , cord-274141-vujx538o 362 4 a a DT cord-274141-vujx538o 362 5 major major JJ cord-274141-vujx538o 362 6 triterpene triterpene JJ cord-274141-vujx538o 362 7 glycoside glycoside NN cord-274141-vujx538o 362 8 isolated isolate VBN cord-274141-vujx538o 362 9 from from IN cord-274141-vujx538o 362 10 Glycyrrhiza Glycyrrhiza NNP cord-274141-vujx538o 362 11 species specie NNS cord-274141-vujx538o 362 12 , , , cord-274141-vujx538o 362 13 has have VBZ cord-274141-vujx538o 362 14 activity activity NN cord-274141-vujx538o 362 15 against against IN cord-274141-vujx538o 362 16 several several JJ cord-274141-vujx538o 362 17 enveloped envelop VBN cord-274141-vujx538o 362 18 viruses virus NNS cord-274141-vujx538o 362 19 including include VBG cord-274141-vujx538o 362 20 SARS SARS NNP cord-274141-vujx538o 362 21 - - HYPH cord-274141-vujx538o 362 22 CoV CoV NNP cord-274141-vujx538o 362 23 and and CC cord-274141-vujx538o 362 24 HIV HIV NNP cord-274141-vujx538o 362 25 . . . cord-274141-vujx538o 363 1 Diammonium Diammonium NNP cord-274141-vujx538o 363 2 glycyrrhizinate glycyrrhizinate NN cord-274141-vujx538o 363 3 , , , cord-274141-vujx538o 363 4 extracted extract VBN cord-274141-vujx538o 363 5 and and CC cord-274141-vujx538o 363 6 purified purify VBN cord-274141-vujx538o 363 7 from from IN cord-274141-vujx538o 363 8 G. G. NNP cord-274141-vujx538o 363 9 uralensis uralensis NN cord-274141-vujx538o 363 10 , , , cord-274141-vujx538o 363 11 inhibited inhibited JJ cord-274141-vujx538o 363 12 SARS SARS NNP cord-274141-vujx538o 363 13 - - HYPH cord-274141-vujx538o 363 14 CoVs CoVs NNP cord-274141-vujx538o 363 15 . . . cord-274141-vujx538o 364 1 Ho Ho NNP cord-274141-vujx538o 364 2 et et FW cord-274141-vujx538o 364 3 al al NNP cord-274141-vujx538o 364 4 . . . cord-274141-vujx538o 365 1 ( ( -LRB- cord-274141-vujx538o 365 2 2007 2007 CD cord-274141-vujx538o 365 3 ) ) -RRB- cord-274141-vujx538o 365 4 found find VBD cord-274141-vujx538o 365 5 that that IN cord-274141-vujx538o 365 6 two two CD cord-274141-vujx538o 365 7 widely widely RB cord-274141-vujx538o 365 8 used use VBN cord-274141-vujx538o 365 9 TCM TCM NNP cord-274141-vujx538o 365 10 plants plant NNS cord-274141-vujx538o 365 11 in in IN cord-274141-vujx538o 365 12 the the DT cord-274141-vujx538o 365 13 family family NN cord-274141-vujx538o 366 1 Polygonaceae Polygonaceae NNP cord-274141-vujx538o 366 2 inhibited inhibit VBD cord-274141-vujx538o 366 3 the the DT cord-274141-vujx538o 366 4 interaction interaction NN cord-274141-vujx538o 366 5 of of IN cord-274141-vujx538o 366 6 SARS SARS NNP cord-274141-vujx538o 366 7 - - HYPH cord-274141-vujx538o 366 8 CoV CoV NNP cord-274141-vujx538o 366 9 spike spike NN cord-274141-vujx538o 366 10 protein protein NN cord-274141-vujx538o 366 11 and and CC cord-274141-vujx538o 366 12 ACE2 ACE2 NNP cord-274141-vujx538o 366 13 ; ; : cord-274141-vujx538o 366 14 the the DT cord-274141-vujx538o 366 15 IC IC NNP cord-274141-vujx538o 366 16 50 50 CD cord-274141-vujx538o 366 17 values value NNS cord-274141-vujx538o 366 18 for for IN cord-274141-vujx538o 366 19 extracts extract NNS cord-274141-vujx538o 366 20 of of IN cord-274141-vujx538o 366 21 the the DT cord-274141-vujx538o 366 22 root root NN cord-274141-vujx538o 366 23 tubers tuber NNS cord-274141-vujx538o 366 24 of of IN cord-274141-vujx538o 366 25 Rheum Rheum NNP cord-274141-vujx538o 366 26 officinale officinale NN cord-274141-vujx538o 366 27 Baill Baill NNP cord-274141-vujx538o 366 28 . . . cord-274141-vujx538o 367 1 and and CC cord-274141-vujx538o 367 2 the the DT cord-274141-vujx538o 367 3 root root NN cord-274141-vujx538o 367 4 tubers tuber NNS cord-274141-vujx538o 367 5 / / SYM cord-274141-vujx538o 367 6 vines vine NNS cord-274141-vujx538o 367 7 of of IN cord-274141-vujx538o 367 8 Polygonum Polygonum NNP cord-274141-vujx538o 367 9 multiflorum multiflorum NNP cord-274141-vujx538o 367 10 ranged range VBD cord-274141-vujx538o 367 11 from from IN cord-274141-vujx538o 367 12 1 1 CD cord-274141-vujx538o 367 13 to to IN cord-274141-vujx538o 367 14 10 10 CD cord-274141-vujx538o 367 15 μ μ NN cord-274141-vujx538o 367 16 / / CC cord-274141-vujx538o 367 17 ml ml NN cord-274141-vujx538o 368 1 ( ( -LRB- cord-274141-vujx538o 368 2 Ho Ho NNP cord-274141-vujx538o 368 3 et et FW cord-274141-vujx538o 368 4 al al NNP cord-274141-vujx538o 368 5 . . NNP cord-274141-vujx538o 368 6 2007 2007 CD cord-274141-vujx538o 368 7 ) ) -RRB- cord-274141-vujx538o 368 8 . . . cord-274141-vujx538o 369 1 Chen Chen NNP cord-274141-vujx538o 369 2 et et NNP cord-274141-vujx538o 369 3 al al NNP cord-274141-vujx538o 369 4 . . . cord-274141-vujx538o 370 1 ( ( -LRB- cord-274141-vujx538o 370 2 2020 2020 CD cord-274141-vujx538o 370 3 ) ) -RRB- cord-274141-vujx538o 370 4 stated state VBD cord-274141-vujx538o 370 5 that that IN cord-274141-vujx538o 370 6 the the DT cord-274141-vujx538o 370 7 mortality mortality NN cord-274141-vujx538o 370 8 of of IN cord-274141-vujx538o 370 9 COVID-19 covid-19 JJ cord-274141-vujx538o 370 10 patients patient NNS cord-274141-vujx538o 370 11 in in IN cord-274141-vujx538o 370 12 China China NNP cord-274141-vujx538o 370 13 was be VBD cord-274141-vujx538o 370 14 markedly markedly RB cord-274141-vujx538o 370 15 reduced reduce VBN cord-274141-vujx538o 370 16 because because IN cord-274141-vujx538o 370 17 of of IN cord-274141-vujx538o 370 18 effective effective JJ cord-274141-vujx538o 370 19 combination combination NN cord-274141-vujx538o 370 20 therapy therapy NN cord-274141-vujx538o 370 21 of of IN cord-274141-vujx538o 370 22 TCM TCM NNP cord-274141-vujx538o 370 23 and and CC cord-274141-vujx538o 370 24 Western western JJ cord-274141-vujx538o 370 25 medicines medicine NNS cord-274141-vujx538o 370 26 . . . cord-274141-vujx538o 371 1 At at RB cord-274141-vujx538o 371 2 least least RBS cord-274141-vujx538o 371 3 20 20 CD cord-274141-vujx538o 371 4 patent patent NN cord-274141-vujx538o 371 5 TCMs tcm NNS cord-274141-vujx538o 371 6 were be VBD cord-274141-vujx538o 371 7 recommended recommend VBN cord-274141-vujx538o 371 8 by by IN cord-274141-vujx538o 371 9 government government NN cord-274141-vujx538o 371 10 guidelines guideline NNS cord-274141-vujx538o 371 11 in in IN cord-274141-vujx538o 371 12 the the DT cord-274141-vujx538o 371 13 treatment treatment NN cord-274141-vujx538o 371 14 of of IN cord-274141-vujx538o 371 15 COVID-19 covid-19 JJ cord-274141-vujx538o 371 16 patients patient NNS cord-274141-vujx538o 371 17 in in IN cord-274141-vujx538o 371 18 China China NNP cord-274141-vujx538o 371 19 . . . cord-274141-vujx538o 372 1 Several several JJ cord-274141-vujx538o 372 2 TCM TCM NNP cord-274141-vujx538o 372 3 plant plant NN cord-274141-vujx538o 372 4 formulae formula NNS cord-274141-vujx538o 372 5 for for IN cord-274141-vujx538o 372 6 treating treat VBG cord-274141-vujx538o 372 7 SARS SARS NNP cord-274141-vujx538o 372 8 - - HYPH cord-274141-vujx538o 372 9 CoV CoV NNP cord-274141-vujx538o 372 10 and and CC cord-274141-vujx538o 372 11 COVID-19 COVID-19 NNP cord-274141-vujx538o 372 12 were be VBD cord-274141-vujx538o 372 13 reported report VBN cord-274141-vujx538o 372 14 by by IN cord-274141-vujx538o 372 15 Yang Yang NNP cord-274141-vujx538o 372 16 et et NNP cord-274141-vujx538o 372 17 al al NNP cord-274141-vujx538o 372 18 . . . cord-274141-vujx538o 373 1 ( ( -LRB- cord-274141-vujx538o 373 2 2020 2020 CD cord-274141-vujx538o 373 3 ) ) -RRB- cord-274141-vujx538o 373 4 . . . cord-274141-vujx538o 374 1 In in IN cord-274141-vujx538o 374 2 Lebanon Lebanon NNP cord-274141-vujx538o 374 3 , , , cord-274141-vujx538o 374 4 the the DT cord-274141-vujx538o 374 5 oil oil NN cord-274141-vujx538o 374 6 of of IN cord-274141-vujx538o 374 7 Laurus Laurus NNP cord-274141-vujx538o 374 8 nobilis nobilis NN cord-274141-vujx538o 374 9 Cav Cav NNP cord-274141-vujx538o 374 10 . . NNP cord-274141-vujx538o 374 11 exerted exert VBD cord-274141-vujx538o 374 12 remarkable remarkable JJ cord-274141-vujx538o 374 13 activity activity NN cord-274141-vujx538o 374 14 against against IN cord-274141-vujx538o 374 15 SARS SARS NNP cord-274141-vujx538o 374 16 - - HYPH cord-274141-vujx538o 374 17 CoV CoV NNP cord-274141-vujx538o 374 18 with with IN cord-274141-vujx538o 374 19 an an DT cord-274141-vujx538o 374 20 IC IC NNP cord-274141-vujx538o 374 21 50 50 CD cord-274141-vujx538o 374 22 value value NN cord-274141-vujx538o 374 23 of of IN cord-274141-vujx538o 374 24 120 120 CD cord-274141-vujx538o 374 25 μg μg NNS cord-274141-vujx538o 374 26 / / SYM cord-274141-vujx538o 374 27 ml ml NN cord-274141-vujx538o 374 28 and and CC cord-274141-vujx538o 374 29 a a DT cord-274141-vujx538o 374 30 selectivity selectivity NN cord-274141-vujx538o 374 31 index index NN cord-274141-vujx538o 374 32 of of IN cord-274141-vujx538o 374 33 4.16 4.16 CD cord-274141-vujx538o 375 1 ( ( -LRB- cord-274141-vujx538o 375 2 Loizzo Loizzo NNP cord-274141-vujx538o 375 3 et et FW cord-274141-vujx538o 375 4 al al NNP cord-274141-vujx538o 375 5 . . NNP cord-274141-vujx538o 375 6 2008 2008 CD cord-274141-vujx538o 375 7 ) ) -RRB- cord-274141-vujx538o 375 8 . . . cord-274141-vujx538o 376 1 An an DT cord-274141-vujx538o 376 2 ornamental ornamental JJ cord-274141-vujx538o 376 3 tree tree NN cord-274141-vujx538o 376 4 and and CC cord-274141-vujx538o 376 5 a a DT cord-274141-vujx538o 376 6 member member NN cord-274141-vujx538o 376 7 of of IN cord-274141-vujx538o 376 8 the the DT cord-274141-vujx538o 376 9 Cupressaceae Cupressaceae NNP cord-274141-vujx538o 376 10 family family NN cord-274141-vujx538o 376 11 , , , cord-274141-vujx538o 376 12 Cupressus Cupressus NNP cord-274141-vujx538o 376 13 sempervirens sempervirens NNP cord-274141-vujx538o 376 14 L. L. NNP cord-274141-vujx538o 376 15 contains contain VBZ cord-274141-vujx538o 376 16 flavonoid flavonoid NN cord-274141-vujx538o 376 17 derivatives derivative NNS cord-274141-vujx538o 376 18 , , , cord-274141-vujx538o 376 19 dit dit NNP cord-274141-vujx538o 376 20 e e NN cord-274141-vujx538o 376 21 r r NN cord-274141-vujx538o 376 22 p p NN cord-274141-vujx538o 376 23 e e NN cord-274141-vujx538o 376 24 n n NN cord-274141-vujx538o 376 25 e e NNP cord-274141-vujx538o 376 26 s s NNP cord-274141-vujx538o 376 27 , , , cord-274141-vujx538o 376 28 c c NNP cord-274141-vujx538o 376 29 a a DT cord-274141-vujx538o 377 1 t t NNP cord-274141-vujx538o 377 2 e e NNP cord-274141-vujx538o 377 3 c c NN cord-274141-vujx538o 377 4 h h NNP cord-274141-vujx538o 377 5 i i NNP cord-274141-vujx538o 377 6 n n NNP cord-274141-vujx538o 377 7 s s NNP cord-274141-vujx538o 377 8 a a NNP cord-274141-vujx538o 377 9 n n NN cord-274141-vujx538o 377 10 d d NN cord-274141-vujx538o 377 11 f f NNP cord-274141-vujx538o 377 12 l l NNP cord-274141-vujx538o 377 13 a a NN cord-274141-vujx538o 377 14 v v NN cord-274141-vujx538o 377 15 o o NN cord-274141-vujx538o 377 16 n n NN cord-274141-vujx538o 378 1 o o UH cord-274141-vujx538o 378 2 l l NN cord-274141-vujx538o 379 1 i i PRP cord-274141-vujx538o 380 1 c c NNP cord-274141-vujx538o 380 2 o o NN cord-274141-vujx538o 380 3 l l NN cord-274141-vujx538o 380 4 i i NN cord-274141-vujx538o 380 5 g g NN cord-274141-vujx538o 380 6 o o NN cord-274141-vujx538o 380 7 m m NN cord-274141-vujx538o 380 8 e e NN cord-274141-vujx538o 380 9 r r NNP cord-274141-vujx538o 380 10 s s NNP cord-274141-vujx538o 380 11 , , , cord-274141-vujx538o 380 12 proanthocyanidins proanthocyanidins NNP cord-274141-vujx538o 380 13 , , , cord-274141-vujx538o 380 14 phenolic phenolic JJ cord-274141-vujx538o 380 15 acids acid NNS cord-274141-vujx538o 380 16 , , , cord-274141-vujx538o 380 17 fatty fatty JJ cord-274141-vujx538o 380 18 acids acid NNS cord-274141-vujx538o 380 19 , , , cord-274141-vujx538o 380 20 and and CC cord-274141-vujx538o 380 21 essential essential JJ cord-274141-vujx538o 380 22 oils oil NNS cord-274141-vujx538o 380 23 ( ( -LRB- cord-274141-vujx538o 380 24 Orhan Orhan NNP cord-274141-vujx538o 380 25 and and CC cord-274141-vujx538o 380 26 Tumen Tumen NNP cord-274141-vujx538o 380 27 2015 2015 CD cord-274141-vujx538o 380 28 ) ) -RRB- cord-274141-vujx538o 380 29 . . . cord-274141-vujx538o 381 1 The the DT cord-274141-vujx538o 381 2 essential essential JJ cord-274141-vujx538o 381 3 oil oil NN cord-274141-vujx538o 381 4 of of IN cord-274141-vujx538o 381 5 C. C. NNP cord-274141-vujx538o 381 6 sempervirens sempervirens NNP cord-274141-vujx538o 381 7 had have VBD cord-274141-vujx538o 381 8 a a DT cord-274141-vujx538o 381 9 mild mild JJ cord-274141-vujx538o 381 10 inhibitory inhibitory JJ cord-274141-vujx538o 381 11 outcome outcome NN cord-274141-vujx538o 381 12 on on IN cord-274141-vujx538o 381 13 SARS SARS NNP cord-274141-vujx538o 381 14 - - HYPH cord-274141-vujx538o 381 15 CoV CoV NNP cord-274141-vujx538o 381 16 activity activity NN cord-274141-vujx538o 381 17 ( ( -LRB- cord-274141-vujx538o 381 18 700 700 CD cord-274141-vujx538o 381 19 ± ± CD cord-274141-vujx538o 381 20 2.3 2.3 CD cord-274141-vujx538o 381 21 μg μg NNP cord-274141-vujx538o 381 22 / / SYM cord-274141-vujx538o 381 23 ml ml NN cord-274141-vujx538o 381 24 ) ) -RRB- cord-274141-vujx538o 382 1 ( ( -LRB- cord-274141-vujx538o 382 2 Orhan Orhan NNP cord-274141-vujx538o 382 3 and and CC cord-274141-vujx538o 382 4 Tumen Tumen NNP cord-274141-vujx538o 382 5 2015 2015 CD cord-274141-vujx538o 382 6 ; ; : cord-274141-vujx538o 382 7 Loizzo Loizzo NNP cord-274141-vujx538o 382 8 et et NNP cord-274141-vujx538o 382 9 al al NNP cord-274141-vujx538o 382 10 . . NNP cord-274141-vujx538o 382 11 2008 2008 CD cord-274141-vujx538o 382 12 ) ) -RRB- cord-274141-vujx538o 382 13 . . . cord-274141-vujx538o 383 1 Volatile volatile JJ cord-274141-vujx538o 383 2 oils oil NNS cord-274141-vujx538o 383 3 are be VBP cord-274141-vujx538o 383 4 potential potential JJ cord-274141-vujx538o 383 5 agents agent NNS cord-274141-vujx538o 383 6 for for IN cord-274141-vujx538o 383 7 treatment treatment NN cord-274141-vujx538o 383 8 of of IN cord-274141-vujx538o 383 9 SARS SARS NNP cord-274141-vujx538o 383 10 - - HYPH cord-274141-vujx538o 383 11 CoV CoV NNP cord-274141-vujx538o 383 12 ( ( -LRB- cord-274141-vujx538o 383 13 Pasdaran Pasdaran NNP cord-274141-vujx538o 383 14 et et NNP cord-274141-vujx538o 383 15 al al NNP cord-274141-vujx538o 383 16 . . . cord-274141-vujx538o 383 17 2016 2016 CD cord-274141-vujx538o 383 18 ) ) -RRB- cord-274141-vujx538o 383 19 . . . cord-274141-vujx538o 384 1 An an DT cord-274141-vujx538o 384 2 ethanolic ethanolic JJ cord-274141-vujx538o 384 3 extract extract NN cord-274141-vujx538o 384 4 of of IN cord-274141-vujx538o 384 5 Thymus Thymus NNP cord-274141-vujx538o 384 6 vulgaris vulgaris NN cord-274141-vujx538o 384 7 Sm Sm NNP cord-274141-vujx538o 384 8 . . . cord-274141-vujx538o 385 1 found find VBN cord-274141-vujx538o 385 2 in in IN cord-274141-vujx538o 385 3 Lebanon Lebanon NNP cord-274141-vujx538o 385 4 inhibits inhibit VBZ cord-274141-vujx538o 385 5 SARS SARS NNP cord-274141-vujx538o 385 6 - - HYPH cord-274141-vujx538o 385 7 CoV CoV NNP cord-274141-vujx538o 385 8 ( ( -LRB- cord-274141-vujx538o 385 9 Bekut Bekut NNP cord-274141-vujx538o 385 10 et et NNP cord-274141-vujx538o 385 11 al al NNP cord-274141-vujx538o 385 12 . . . cord-274141-vujx538o 385 13 2018 2018 CD cord-274141-vujx538o 385 14 ) ) -RRB- cord-274141-vujx538o 385 15 . . . cord-274141-vujx538o 386 1 Lebanese lebanese JJ cord-274141-vujx538o 386 2 essential essential JJ cord-274141-vujx538o 386 3 oils oil NNS cord-274141-vujx538o 386 4 have have VBP cord-274141-vujx538o 386 5 also also RB cord-274141-vujx538o 386 6 been be VBN cord-274141-vujx538o 386 7 evaluated evaluate VBN cord-274141-vujx538o 386 8 for for IN cord-274141-vujx538o 386 9 their -PRON- PRP$ cord-274141-vujx538o 386 10 inhibitory inhibitory JJ cord-274141-vujx538o 386 11 activity activity NN cord-274141-vujx538o 386 12 against against IN cord-274141-vujx538o 386 13 SARS SARS NNP cord-274141-vujx538o 386 14 - - HYPH cord-274141-vujx538o 386 15 CoV cov NN cord-274141-vujx538o 386 16 replication replication NN cord-274141-vujx538o 386 17 in in IN cord-274141-vujx538o 386 18 vitro vitro FW cord-274141-vujx538o 386 19 by by IN cord-274141-vujx538o 386 20 visually visually RB cord-274141-vujx538o 386 21 scoring score VBG cord-274141-vujx538o 386 22 the the DT cord-274141-vujx538o 386 23 virus virus NN cord-274141-vujx538o 386 24 - - HYPH cord-274141-vujx538o 386 25 induced induce VBN cord-274141-vujx538o 386 26 cytopathogenic cytopathogenic JJ cord-274141-vujx538o 386 27 effect effect NN cord-274141-vujx538o 386 28 post post NN cord-274141-vujx538o 386 29 infection infection NN cord-274141-vujx538o 386 30 . . . cord-274141-vujx538o 387 1 The the DT cord-274141-vujx538o 387 2 papain papain NN cord-274141-vujx538o 387 3 - - HYPH cord-274141-vujx538o 387 4 like like JJ cord-274141-vujx538o 387 5 protease protease NN cord-274141-vujx538o 387 6 ( ( -LRB- cord-274141-vujx538o 387 7 PL pl NN cord-274141-vujx538o 387 8 pro pro NN cord-274141-vujx538o 387 9 ) ) -RRB- cord-274141-vujx538o 387 10 encoded encode VBN cord-274141-vujx538o 387 11 by by IN cord-274141-vujx538o 387 12 SARS SARS NNP cord-274141-vujx538o 387 13 - - HYPH cord-274141-vujx538o 387 14 CoV CoV NNP cord-274141-vujx538o 387 15 cleaves cleave VBZ cord-274141-vujx538o 387 16 the the DT cord-274141-vujx538o 387 17 viral viral JJ cord-274141-vujx538o 387 18 replicase replicase NNP cord-274141-vujx538o 387 19 polyprotein polyprotein NNP cord-274141-vujx538o 387 20 . . . cord-274141-vujx538o 388 1 Since since IN cord-274141-vujx538o 388 2 this this DT cord-274141-vujx538o 388 3 enzymatic enzymatic JJ cord-274141-vujx538o 388 4 activity activity NN cord-274141-vujx538o 388 5 is be VBZ cord-274141-vujx538o 388 6 important important JJ cord-274141-vujx538o 388 7 for for IN cord-274141-vujx538o 388 8 viral viral JJ cord-274141-vujx538o 388 9 infection infection NN cord-274141-vujx538o 388 10 , , , cord-274141-vujx538o 388 11 PL pl NN cord-274141-vujx538o 388 12 pro pro NNP cord-274141-vujx538o 388 13 is be VBZ cord-274141-vujx538o 388 14 a a DT cord-274141-vujx538o 388 15 target target NN cord-274141-vujx538o 388 16 of of IN cord-274141-vujx538o 388 17 interest interest NN cord-274141-vujx538o 388 18 in in IN cord-274141-vujx538o 388 19 the the DT cord-274141-vujx538o 388 20 development development NN cord-274141-vujx538o 388 21 of of IN cord-274141-vujx538o 388 22 antiviral antiviral JJ cord-274141-vujx538o 388 23 therapies therapy NNS cord-274141-vujx538o 388 24 . . . cord-274141-vujx538o 389 1 Nine nine CD cord-274141-vujx538o 389 2 diarylheptanoids diarylheptanoid NNS cord-274141-vujx538o 389 3 from from IN cord-274141-vujx538o 389 4 the the DT cord-274141-vujx538o 389 5 bark bark NN cord-274141-vujx538o 389 6 of of IN cord-274141-vujx538o 389 7 Alnus Alnus NNP cord-274141-vujx538o 389 8 japonica japonica NN cord-274141-vujx538o 389 9 ( ( -LRB- cord-274141-vujx538o 389 10 Thunb Thunb NNP cord-274141-vujx538o 389 11 . . . cord-274141-vujx538o 389 12 ) ) -RRB- cord-274141-vujx538o 390 1 Steud Steud NNP cord-274141-vujx538o 390 2 . . . cord-274141-vujx538o 390 3 were be VBD cord-274141-vujx538o 390 4 evaluated evaluate VBN cord-274141-vujx538o 390 5 for for IN cord-274141-vujx538o 390 6 their -PRON- PRP$ cord-274141-vujx538o 390 7 inhibitory inhibitory JJ cord-274141-vujx538o 390 8 activities activity NNS cord-274141-vujx538o 390 9 against against IN cord-274141-vujx538o 390 10 SARS SARS NNP cord-274141-vujx538o 390 11 - - HYPH cord-274141-vujx538o 390 12 CoV CoV NNP cord-274141-vujx538o 390 13 PL pl NN cord-274141-vujx538o 390 14 pro pro NNP cord-274141-vujx538o 390 15 . . . cord-274141-vujx538o 391 1 Hirsutenone Hirsutenone NNP cord-274141-vujx538o 391 2 was be VBD cord-274141-vujx538o 391 3 found find VBN cord-274141-vujx538o 391 4 to to TO cord-274141-vujx538o 391 5 be be VB cord-274141-vujx538o 391 6 the the DT cord-274141-vujx538o 391 7 most most RBS cord-274141-vujx538o 391 8 potent potent JJ cord-274141-vujx538o 391 9 inhibitor inhibitor NN cord-274141-vujx538o 391 10 of of IN cord-274141-vujx538o 391 11 SARS SARS NNP cord-274141-vujx538o 391 12 - - HYPH cord-274141-vujx538o 391 13 CoV CoV NNP cord-274141-vujx538o 391 14 PL pl NN cord-274141-vujx538o 391 15 pro pro JJ cord-274141-vujx538o 391 16 ( ( -LRB- cord-274141-vujx538o 391 17 IC IC NNP cord-274141-vujx538o 391 18 50 50 CD cord-274141-vujx538o 391 19 of of IN cord-274141-vujx538o 391 20 4.1 4.1 CD cord-274141-vujx538o 391 21 ± ± CD cord-274141-vujx538o 391 22 0.3 0.3 CD cord-274141-vujx538o 391 23 μM μM NNP cord-274141-vujx538o 391 24 ) ) -RRB- cord-274141-vujx538o 391 25 . . . cord-274141-vujx538o 392 1 Seven seven CD cord-274141-vujx538o 392 2 tanshinones tanshinone NNS cord-274141-vujx538o 392 3 isolated isolate VBN cord-274141-vujx538o 392 4 from from IN cord-274141-vujx538o 392 5 Salvia Salvia NNP cord-274141-vujx538o 392 6 miltiorrhiza miltiorrhiza NNP cord-274141-vujx538o 392 7 Bunge Bunge NNP cord-274141-vujx538o 392 8 . . . cord-274141-vujx538o 393 1 were be VBD cord-274141-vujx538o 393 2 selective selective JJ cord-274141-vujx538o 393 3 inhibitors inhibitor NNS cord-274141-vujx538o 393 4 of of IN cord-274141-vujx538o 393 5 SARS SARS NNP cord-274141-vujx538o 393 6 - - HYPH cord-274141-vujx538o 393 7 CoV CoV NNP cord-274141-vujx538o 393 8 3CL 3CL NNP cord-274141-vujx538o 393 9 Pro Pro NNP cord-274141-vujx538o 393 10 and and CC cord-274141-vujx538o 393 11 PL PL NNP cord-274141-vujx538o 393 12 Pro pro JJ cord-274141-vujx538o 393 13 viral viral JJ cord-274141-vujx538o 393 14 cysteine cysteine NN cord-274141-vujx538o 393 15 proteases protease NNS cord-274141-vujx538o 393 16 with with IN cord-274141-vujx538o 393 17 IC IC NNP cord-274141-vujx538o 393 18 50 50 CD cord-274141-vujx538o 393 19 values value NNS cord-274141-vujx538o 393 20 from from IN cord-274141-vujx538o 393 21 0.8 0.8 CD cord-274141-vujx538o 393 22 to to IN cord-274141-vujx538o 393 23 30 30 CD cord-274141-vujx538o 394 1 μM μM NNP cord-274141-vujx538o 395 1 ( ( -LRB- cord-274141-vujx538o 395 2 Park Park NNP cord-274141-vujx538o 395 3 et et FW cord-274141-vujx538o 395 4 al al NNP cord-274141-vujx538o 395 5 . . NNP cord-274141-vujx538o 395 6 2012b 2012b CD cord-274141-vujx538o 395 7 ) ) -RRB- cord-274141-vujx538o 395 8 . . . cord-274141-vujx538o 396 1 Cryptotanshinone Cryptotanshinone NNP cord-274141-vujx538o 396 2 was be VBD cord-274141-vujx538o 396 3 the the DT cord-274141-vujx538o 396 4 most most RBS cord-274141-vujx538o 396 5 potent potent JJ cord-274141-vujx538o 396 6 inhibitor inhibitor NN cord-274141-vujx538o 396 7 of of IN cord-274141-vujx538o 396 8 SARS SARS NNP cord-274141-vujx538o 396 9 - - HYPH cord-274141-vujx538o 396 10 CoV CoV NNP cord-274141-vujx538o 396 11 PL PL NNP cord-274141-vujx538o 396 12 Pro Pro NNP cord-274141-vujx538o 396 13 . . . cord-274141-vujx538o 397 1 Cho Cho NNP cord-274141-vujx538o 397 2 et et FW cord-274141-vujx538o 397 3 al al NNP cord-274141-vujx538o 397 4 . . . cord-274141-vujx538o 398 1 ( ( -LRB- cord-274141-vujx538o 398 2 2013 2013 CD cord-274141-vujx538o 398 3 ) ) -RRB- cord-274141-vujx538o 398 4 obtained obtain VBD cord-274141-vujx538o 398 5 12 12 CD cord-274141-vujx538o 398 6 flavonoids flavonoid NNS cord-274141-vujx538o 398 7 from from IN cord-274141-vujx538o 398 8 the the DT cord-274141-vujx538o 398 9 fruits fruit NNS cord-274141-vujx538o 398 10 of of IN cord-274141-vujx538o 398 11 Paulownia Paulownia NNP cord-274141-vujx538o 398 12 tomentosa tomentosa NN cord-274141-vujx538o 398 13 that that WDT cord-274141-vujx538o 398 14 function function NN cord-274141-vujx538o 398 15 as as IN cord-274141-vujx538o 398 16 SARS SARS NNP cord-274141-vujx538o 398 17 - - HYPH cord-274141-vujx538o 398 18 CoV CoV NNP cord-274141-vujx538o 398 19 PL PL NNP cord-274141-vujx538o 398 20 Pro Pro NNP cord-274141-vujx538o 398 21 inhibitors inhibitor NNS cord-274141-vujx538o 398 22 . . . cord-274141-vujx538o 399 1 These these DT cord-274141-vujx538o 399 2 flavonoids flavonoid NNS cord-274141-vujx538o 399 3 resulted result VBD cord-274141-vujx538o 399 4 in in IN cord-274141-vujx538o 399 5 significant significant JJ cord-274141-vujx538o 399 6 inhibition inhibition NN cord-274141-vujx538o 399 7 of of IN cord-274141-vujx538o 399 8 SARS SARS NNP cord-274141-vujx538o 399 9 - - HYPH cord-274141-vujx538o 399 10 CoV CoV NNP cord-274141-vujx538o 399 11 PL PL NNP cord-274141-vujx538o 399 12 pro pro JJ cord-274141-vujx538o 399 13 in in IN cord-274141-vujx538o 399 14 a a DT cord-274141-vujx538o 399 15 dose dose NN cord-274141-vujx538o 399 16 - - HYPH cord-274141-vujx538o 399 17 dependent dependent JJ cord-274141-vujx538o 399 18 manner manner NN cord-274141-vujx538o 399 19 . . . cord-274141-vujx538o 400 1 Tomentin Tomentin NNP cord-274141-vujx538o 400 2 E E NNS cord-274141-vujx538o 400 3 exhibited exhibit VBD cord-274141-vujx538o 400 4 the the DT cord-274141-vujx538o 400 5 highest high JJS cord-274141-vujx538o 400 6 inhibitory inhibitory JJ cord-274141-vujx538o 400 7 effect effect NN cord-274141-vujx538o 400 8 with with IN cord-274141-vujx538o 400 9 an an DT cord-274141-vujx538o 400 10 IC IC NNP cord-274141-vujx538o 400 11 50 50 CD cord-274141-vujx538o 400 12 of of IN cord-274141-vujx538o 400 13 5 5 CD cord-274141-vujx538o 400 14 ± ± CD cord-274141-vujx538o 400 15 0.06 0.06 CD cord-274141-vujx538o 400 16 μM μM NNP cord-274141-vujx538o 400 17 . . . cord-274141-vujx538o 401 1 Tomentin Tomentin NNP cord-274141-vujx538o 401 2 isolated isolate VBN cord-274141-vujx538o 401 3 from from IN cord-274141-vujx538o 401 4 Sphaeralcea Sphaeralcea NNP cord-274141-vujx538o 401 5 angustifolia angustifolia NNP cord-274141-vujx538o 401 6 ( ( -LRB- cord-274141-vujx538o 401 7 Cav Cav NNP cord-274141-vujx538o 401 8 . . . cord-274141-vujx538o 401 9 ) ) -RRB- cord-274141-vujx538o 402 1 G.Don G.Don NNP cord-274141-vujx538o 402 2 inhibited inhibit VBD cord-274141-vujx538o 402 3 PL PL NNP cord-274141-vujx538o 402 4 Pro Pro NNP cord-274141-vujx538o 402 5 with with IN cord-274141-vujx538o 402 6 IC IC NNP cord-274141-vujx538o 402 7 50 50 CD cord-274141-vujx538o 402 8 values value NNS cord-274141-vujx538o 402 9 ranging range VBG cord-274141-vujx538o 402 10 from from IN cord-274141-vujx538o 402 11 5 5 CD cord-274141-vujx538o 402 12 to to IN cord-274141-vujx538o 402 13 14.4 14.4 CD cord-274141-vujx538o 402 14 μM. μm. NN cord-274141-vujx538o 402 15 Singapore Singapore NNP cord-274141-vujx538o 402 16 Chiow Chiow NNP cord-274141-vujx538o 402 17 et et NNP cord-274141-vujx538o 402 18 al al NNP cord-274141-vujx538o 402 19 . . . cord-274141-vujx538o 403 1 ( ( -LRB- cord-274141-vujx538o 403 2 2016 2016 CD cord-274141-vujx538o 403 3 ) ) -RRB- cord-274141-vujx538o 403 4 conducted conduct VBN cord-274141-vujx538o 403 5 in in IN cord-274141-vujx538o 403 6 vitro vitro FW cord-274141-vujx538o 403 7 virus virus NN cord-274141-vujx538o 403 8 neutralization neutralization NN cord-274141-vujx538o 403 9 assays assay NNS cord-274141-vujx538o 403 10 where where WRB cord-274141-vujx538o 403 11 an an DT cord-274141-vujx538o 403 12 ethyl ethyl NN cord-274141-vujx538o 403 13 acetate acetate NN cord-274141-vujx538o 403 14 ( ( -LRB- cord-274141-vujx538o 403 15 EA EA NNP cord-274141-vujx538o 403 16 ) ) -RRB- cord-274141-vujx538o 403 17 fraction fraction NN cord-274141-vujx538o 403 18 of of IN cord-274141-vujx538o 403 19 Houttuynia Houttuynia NNP cord-274141-vujx538o 403 20 cordata cordata NN cord-274141-vujx538o 403 21 and and CC cord-274141-vujx538o 403 22 three three CD cord-274141-vujx538o 403 23 of of IN cord-274141-vujx538o 403 24 its -PRON- PRP$ cord-274141-vujx538o 403 25 constituent constituent JJ cord-274141-vujx538o 403 26 flavonoids flavonoid NNS cord-274141-vujx538o 403 27 were be VBD cord-274141-vujx538o 403 28 tested test VBN cord-274141-vujx538o 403 29 on on IN cord-274141-vujx538o 403 30 murine murine JJ cord-274141-vujx538o 403 31 coronavirus coronavirus NN cord-274141-vujx538o 403 32 . . . cord-274141-vujx538o 404 1 With with IN cord-274141-vujx538o 404 2 no no DT cord-274141-vujx538o 404 3 cytotoxicity cytotoxicity NN cord-274141-vujx538o 404 4 , , , cord-274141-vujx538o 404 5 the the DT cord-274141-vujx538o 404 6 EA EA NNP cord-274141-vujx538o 404 7 fraction fraction NN cord-274141-vujx538o 404 8 of of IN cord-274141-vujx538o 404 9 H. H. NNP cord-274141-vujx538o 404 10 cordata cordata NN cord-274141-vujx538o 404 11 , , , cord-274141-vujx538o 404 12 added add VBN cord-274141-vujx538o 404 13 before before IN cord-274141-vujx538o 404 14 the the DT cord-274141-vujx538o 404 15 viral viral JJ cord-274141-vujx538o 404 16 adsorption adsorption NN cord-274141-vujx538o 404 17 stage stage NN cord-274141-vujx538o 404 18 , , , cord-274141-vujx538o 404 19 inhibited inhibit VBN cord-274141-vujx538o 404 20 murine murine JJ cord-274141-vujx538o 404 21 coronavirus coronavirus NN cord-274141-vujx538o 404 22 ( ( -LRB- cord-274141-vujx538o 404 23 IC IC NNP cord-274141-vujx538o 404 24 50 50 CD cord-274141-vujx538o 404 25 0.98 0.98 CD cord-274141-vujx538o 404 26 μg μg NNS cord-274141-vujx538o 404 27 / / SYM cord-274141-vujx538o 404 28 ml ml NN cord-274141-vujx538o 404 29 ) ) -RRB- cord-274141-vujx538o 405 1 ( ( -LRB- cord-274141-vujx538o 405 2 Chiow Chiow NNP cord-274141-vujx538o 405 3 et et NNP cord-274141-vujx538o 405 4 al al NNP cord-274141-vujx538o 405 5 . . . cord-274141-vujx538o 405 6 2016 2016 CD cord-274141-vujx538o 405 7 ) ) -RRB- cord-274141-vujx538o 405 8 . . . cord-274141-vujx538o 406 1 The the DT cord-274141-vujx538o 406 2 flavonoid flavonoid NN cord-274141-vujx538o 406 3 quercetin quercetin NN cord-274141-vujx538o 406 4 weakly weakly RB cord-274141-vujx538o 406 5 inhibited inhibit VBD cord-274141-vujx538o 406 6 murine murine JJ cord-274141-vujx538o 406 7 coronavirus coronavirus NN cord-274141-vujx538o 406 8 with with IN cord-274141-vujx538o 406 9 a a DT cord-274141-vujx538o 406 10 minimum minimum JJ cord-274141-vujx538o 406 11 inhibitory inhibitory JJ cord-274141-vujx538o 406 12 concentration concentration NN cord-274141-vujx538o 406 13 of of IN cord-274141-vujx538o 406 14 125 125 CD cord-274141-vujx538o 406 15 μg μg NN cord-274141-vujx538o 406 16 / / SYM cord-274141-vujx538o 406 17 ml ml NN cord-274141-vujx538o 406 18 , , , cord-274141-vujx538o 406 19 cytotoxicity cytotoxicity NN cord-274141-vujx538o 406 20 CC cc NN cord-274141-vujx538o 406 21 50 50 CD cord-274141-vujx538o 406 22 value value NN cord-274141-vujx538o 406 23 of of IN cord-274141-vujx538o 406 24 116.50 116.50 CD cord-274141-vujx538o 406 25 μg μg NNP cord-274141-vujx538o 406 26 / / SYM cord-274141-vujx538o 406 27 ml ml NN cord-274141-vujx538o 406 28 , , , cord-274141-vujx538o 406 29 and and CC cord-274141-vujx538o 406 30 selectivity selectivity NN cord-274141-vujx538o 406 31 index index NN cord-274141-vujx538o 406 32 of of IN cord-274141-vujx538o 406 33 0.93 0.93 CD cord-274141-vujx538o 406 34 . . . cord-274141-vujx538o 407 1 The the DT cord-274141-vujx538o 407 2 EA EA NNP cord-274141-vujx538o 407 3 fraction fraction NN cord-274141-vujx538o 407 4 and and CC cord-274141-vujx538o 407 5 quercetin quercetin NN cord-274141-vujx538o 407 6 yielded yield VBD cord-274141-vujx538o 407 7 a a DT cord-274141-vujx538o 407 8 long long RB cord-274141-vujx538o 407 9 - - HYPH cord-274141-vujx538o 407 10 lasting last VBG cord-274141-vujx538o 407 11 anti anti JJ cord-274141-vujx538o 407 12 - - JJ cord-274141-vujx538o 407 13 murine murine JJ cord-274141-vujx538o 407 14 coronavirus coronavirus NN cord-274141-vujx538o 407 15 effect effect NN cord-274141-vujx538o 407 16 of of IN cord-274141-vujx538o 407 17 up up IN cord-274141-vujx538o 407 18 to to TO cord-274141-vujx538o 407 19 6 6 CD cord-274141-vujx538o 407 20 days day NNS cord-274141-vujx538o 407 21 . . . cord-274141-vujx538o 408 1 Overall overall RB cord-274141-vujx538o 408 2 , , , cord-274141-vujx538o 408 3 this this DT cord-274141-vujx538o 408 4 study study NN cord-274141-vujx538o 408 5 demonstrated demonstrate VBD cord-274141-vujx538o 408 6 that that IN cord-274141-vujx538o 408 7 the the DT cord-274141-vujx538o 408 8 EA EA NNP cord-274141-vujx538o 408 9 fraction fraction NN cord-274141-vujx538o 408 10 of of IN cord-274141-vujx538o 408 11 H. H. NNP cord-274141-vujx538o 408 12 cordata cordata NN cord-274141-vujx538o 408 13 and and CC cord-274141-vujx538o 408 14 its -PRON- PRP$ cord-274141-vujx538o 408 15 flavonoid flavonoid NN cord-274141-vujx538o 408 16 component component NN cord-274141-vujx538o 408 17 , , , cord-274141-vujx538o 408 18 quercetin quercetin NN cord-274141-vujx538o 408 19 , , , cord-274141-vujx538o 408 20 neutralizes neutralize VBZ cord-274141-vujx538o 408 21 murine murine JJ cord-274141-vujx538o 408 22 coronavirus coronavirus NN cord-274141-vujx538o 408 23 in in IN cord-274141-vujx538o 408 24 vitro vitro FW cord-274141-vujx538o 408 25 ( ( -LRB- cord-274141-vujx538o 408 26 Chiow Chiow NNP cord-274141-vujx538o 408 27 et et NNP cord-274141-vujx538o 408 28 al al NNP cord-274141-vujx538o 408 29 . . . cord-274141-vujx538o 408 30 2016 2016 CD cord-274141-vujx538o 408 31 ) ) -RRB- cord-274141-vujx538o 408 32 . . . cord-274141-vujx538o 409 1 The the DT cord-274141-vujx538o 409 2 EPs ep NNS cord-274141-vujx538o 409 3 ® ® VBP cord-274141-vujx538o 409 4 7630 7630 CD cord-274141-vujx538o 409 5 liquid liquid JJ cord-274141-vujx538o 409 6 herbal herbal JJ cord-274141-vujx538o 409 7 drug drug NN cord-274141-vujx538o 409 8 Umckaloabo Umckaloabo NNP cord-274141-vujx538o 409 9 ® ® NNP cord-274141-vujx538o 409 10 , , , cord-274141-vujx538o 409 11 a a DT cord-274141-vujx538o 409 12 100 100 CD cord-274141-vujx538o 409 13 μg μg NN cord-274141-vujx538o 409 14 / / SYM cord-274141-vujx538o 409 15 ml ml NN cord-274141-vujx538o 409 16 extract extract NN cord-274141-vujx538o 409 17 of of IN cord-274141-vujx538o 409 18 Pelargonium Pelargonium NNP cord-274141-vujx538o 409 19 sidoides sidoide NNS cord-274141-vujx538o 409 20 DC DC NNP cord-274141-vujx538o 409 21 . . NNP cord-274141-vujx538o 409 22 , , , cord-274141-vujx538o 409 23 exerts exert VBZ cord-274141-vujx538o 409 24 antiinfluenza antiinfluenza NNP cord-274141-vujx538o 409 25 virus virus NN cord-274141-vujx538o 409 26 activity activity NN cord-274141-vujx538o 409 27 in in IN cord-274141-vujx538o 409 28 vitro vitro FW cord-274141-vujx538o 409 29 and and CC cord-274141-vujx538o 409 30 in in IN cord-274141-vujx538o 409 31 vivo vivo NN cord-274141-vujx538o 410 1 ( ( -LRB- cord-274141-vujx538o 410 2 Theisen Theisen NNP cord-274141-vujx538o 410 3 and and CC cord-274141-vujx538o 410 4 Muller Muller NNP cord-274141-vujx538o 410 5 2012 2012 CD cord-274141-vujx538o 410 6 ) ) -RRB- cord-274141-vujx538o 410 7 . . . cord-274141-vujx538o 411 1 Discovered discover VBN cord-274141-vujx538o 411 2 in in IN cord-274141-vujx538o 411 3 South South NNP cord-274141-vujx538o 411 4 Africa Africa NNP cord-274141-vujx538o 411 5 , , , cord-274141-vujx538o 411 6 Umckaloabo Umckaloabo NNP cord-274141-vujx538o 411 7 , , , cord-274141-vujx538o 411 8 a a DT cord-274141-vujx538o 411 9 decoction decoction NN cord-274141-vujx538o 411 10 of of IN cord-274141-vujx538o 411 11 the the DT cord-274141-vujx538o 411 12 roots root NNS cord-274141-vujx538o 411 13 of of IN cord-274141-vujx538o 411 14 Pelargonium Pelargonium NNP cord-274141-vujx538o 411 15 sidoides sidoide NNS cord-274141-vujx538o 411 16 , , , cord-274141-vujx538o 411 17 was be VBD cord-274141-vujx538o 411 18 originally originally RB cord-274141-vujx538o 411 19 used use VBN cord-274141-vujx538o 411 20 by by IN cord-274141-vujx538o 411 21 Zulu Zulu NNP cord-274141-vujx538o 411 22 traditional traditional JJ cord-274141-vujx538o 411 23 healers healer NNS cord-274141-vujx538o 411 24 as as IN cord-274141-vujx538o 411 25 a a DT cord-274141-vujx538o 411 26 remedy remedy NN cord-274141-vujx538o 411 27 for for IN cord-274141-vujx538o 411 28 acute acute JJ cord-274141-vujx538o 411 29 bronchitis bronchitis NN cord-274141-vujx538o 411 30 . . . cord-274141-vujx538o 412 1 Umckaloabo Umckaloabo NNP cord-274141-vujx538o 412 2 ® ® VBP cord-274141-vujx538o 412 3 is be VBZ cord-274141-vujx538o 412 4 known know VBN cord-274141-vujx538o 412 5 to to TO cord-274141-vujx538o 412 6 inhibit inhibit VB cord-274141-vujx538o 412 7 the the DT cord-274141-vujx538o 412 8 entry entry NN cord-274141-vujx538o 412 9 and and CC cord-274141-vujx538o 412 10 replication replication NN cord-274141-vujx538o 412 11 of of IN cord-274141-vujx538o 412 12 HCoV-229E HCoV-229E NNP cord-274141-vujx538o 412 13 ( ( -LRB- cord-274141-vujx538o 412 14 Michaelis Michaelis NNP cord-274141-vujx538o 412 15 et et NNP cord-274141-vujx538o 412 16 al al NNP cord-274141-vujx538o 412 17 . . NNP cord-274141-vujx538o 412 18 2011 2011 CD cord-274141-vujx538o 412 19 ) ) -RRB- cord-274141-vujx538o 412 20 . . . cord-274141-vujx538o 413 1 It -PRON- PRP cord-274141-vujx538o 413 2 is be VBZ cord-274141-vujx538o 413 3 a a DT cord-274141-vujx538o 413 4 common common JJ cord-274141-vujx538o 413 5 medication medication NN cord-274141-vujx538o 413 6 for for IN cord-274141-vujx538o 413 7 acute acute JJ cord-274141-vujx538o 413 8 bronchitis bronchitis NN cord-274141-vujx538o 413 9 in in IN cord-274141-vujx538o 413 10 South South NNP cord-274141-vujx538o 413 11 Africa Africa NNP cord-274141-vujx538o 413 12 and and CC cord-274141-vujx538o 413 13 Germany Germany NNP cord-274141-vujx538o 413 14 . . . cord-274141-vujx538o 414 1 Although although IN cord-274141-vujx538o 414 2 uncontrolled uncontrolled JJ cord-274141-vujx538o 414 3 human human JJ cord-274141-vujx538o 414 4 trials trial NNS cord-274141-vujx538o 414 5 for for IN cord-274141-vujx538o 414 6 SARS SARS NNP cord-274141-vujx538o 414 7 - - HYPH cord-274141-vujx538o 414 8 CoV CoV NNP cord-274141-vujx538o 414 9 anti anti NNP cord-274141-vujx538o 414 10 - - NNP cord-274141-vujx538o 414 11 infectives infective NNS cord-274141-vujx538o 414 12 have have VBP cord-274141-vujx538o 414 13 been be VBN cord-274141-vujx538o 414 14 reported report VBN cord-274141-vujx538o 414 15 , , , cord-274141-vujx538o 414 16 no no DT cord-274141-vujx538o 414 17 randomized randomized JJ cord-274141-vujx538o 414 18 controlled control VBN cord-274141-vujx538o 414 19 trials trial NNS cord-274141-vujx538o 414 20 with with IN cord-274141-vujx538o 414 21 a a DT cord-274141-vujx538o 414 22 specific specific JJ cord-274141-vujx538o 414 23 anti anti JJ cord-274141-vujx538o 414 24 - - JJ cord-274141-vujx538o 414 25 coronavirus coronavirus JJ cord-274141-vujx538o 414 26 agent agent NN cord-274141-vujx538o 414 27 had have VBD cord-274141-vujx538o 414 28 been be VBN cord-274141-vujx538o 414 29 conducted conduct VBN cord-274141-vujx538o 414 30 with with IN cord-274141-vujx538o 414 31 respect respect NN cord-274141-vujx538o 414 32 to to IN cord-274141-vujx538o 414 33 therapy therapy NN cord-274141-vujx538o 414 34 or or CC cord-274141-vujx538o 414 35 prophylaxis prophylaxis NN cord-274141-vujx538o 414 36 ( ( -LRB- cord-274141-vujx538o 414 37 Wong Wong NNP cord-274141-vujx538o 414 38 and and CC cord-274141-vujx538o 414 39 Yuen Yuen NNP cord-274141-vujx538o 414 40 2008 2008 CD cord-274141-vujx538o 414 41 ) ) -RRB- cord-274141-vujx538o 414 42 . . . cord-274141-vujx538o 415 1 There there EX cord-274141-vujx538o 415 2 had have VBD cord-274141-vujx538o 415 3 not not RB cord-274141-vujx538o 415 4 been be VBN cord-274141-vujx538o 415 5 any any DT cord-274141-vujx538o 415 6 clinical clinical JJ cord-274141-vujx538o 415 7 trials trial NNS cord-274141-vujx538o 415 8 for for IN cord-274141-vujx538o 415 9 drugs drug NNS cord-274141-vujx538o 415 10 of of IN cord-274141-vujx538o 415 11 infections infection NNS cord-274141-vujx538o 415 12 caused cause VBN cord-274141-vujx538o 415 13 by by IN cord-274141-vujx538o 415 14 HCoV HCoV NNP cord-274141-vujx538o 415 15 - - HYPH cord-274141-vujx538o 415 16 OC43 OC43 NNP cord-274141-vujx538o 415 17 , , , cord-274141-vujx538o 415 18 HCoV-229E HCoV-229E NNP cord-274141-vujx538o 415 19 , , , cord-274141-vujx538o 415 20 HCoV HCoV NNP cord-274141-vujx538o 415 21 - - HYPH cord-274141-vujx538o 415 22 NL63 NL63 NNP cord-274141-vujx538o 415 23 , , , cord-274141-vujx538o 415 24 and and CC cord-274141-vujx538o 415 25 HCoV HCoV NNP cord-274141-vujx538o 415 26 - - HYPH cord-274141-vujx538o 415 27 HKU1 HKU1 NNP cord-274141-vujx538o 415 28 ( ( -LRB- cord-274141-vujx538o 415 29 Wong Wong NNP cord-274141-vujx538o 415 30 and and CC cord-274141-vujx538o 415 31 Yuen Yuen NNP cord-274141-vujx538o 415 32 , , , cord-274141-vujx538o 415 33 2008 2008 CD cord-274141-vujx538o 415 34 ) ) -RRB- cord-274141-vujx538o 415 35 . . . cord-274141-vujx538o 416 1 urged urge VBD cord-274141-vujx538o 416 2 that that IN cord-274141-vujx538o 416 3 randomized randomized JJ cord-274141-vujx538o 416 4 placebo placebo NN cord-274141-vujx538o 416 5 control control NN cord-274141-vujx538o 416 6 trials trial NNS cord-274141-vujx538o 416 7 should should MD cord-274141-vujx538o 416 8 assess assess VB cord-274141-vujx538o 416 9 the the DT cord-274141-vujx538o 416 10 efficacy efficacy NN cord-274141-vujx538o 416 11 of of IN cord-274141-vujx538o 416 12 intravenous intravenous JJ cord-274141-vujx538o 416 13 baicalin baicalin NN cord-274141-vujx538o 416 14 ( ( -LRB- cord-274141-vujx538o 416 15 10 10 CD cord-274141-vujx538o 416 16 ) ) -RRB- cord-274141-vujx538o 416 17 for for IN cord-274141-vujx538o 416 18 the the DT cord-274141-vujx538o 416 19 treatment treatment NN cord-274141-vujx538o 416 20 of of IN cord-274141-vujx538o 416 21 SARS SARS NNP cord-274141-vujx538o 416 22 especially especially RB cord-274141-vujx538o 416 23 in in IN cord-274141-vujx538o 416 24 developing develop VBG cord-274141-vujx538o 416 25 countries country NNS cord-274141-vujx538o 416 26 where where WRB cord-274141-vujx538o 416 27 such such JJ cord-274141-vujx538o 416 28 formulations formulation NNS cord-274141-vujx538o 416 29 were be VBD cord-274141-vujx538o 416 30 available available JJ cord-274141-vujx538o 416 31 and and CC cord-274141-vujx538o 416 32 affordable affordable JJ cord-274141-vujx538o 416 33 . . . cord-274141-vujx538o 417 1 In in IN cord-274141-vujx538o 417 2 a a DT cord-274141-vujx538o 417 3 randomized randomized JJ cord-274141-vujx538o 417 4 double double JJ cord-274141-vujx538o 417 5 - - HYPH cord-274141-vujx538o 417 6 blinded blinded JJ cord-274141-vujx538o 417 7 placebo placebo NN cord-274141-vujx538o 417 8 controlled control VBN cord-274141-vujx538o 417 9 trial trial NN cord-274141-vujx538o 417 10 , , , cord-274141-vujx538o 417 11 quercetin quercetin JJ cord-274141-vujx538o 417 12 supplementation supplementation NN cord-274141-vujx538o 417 13 in in IN cord-274141-vujx538o 417 14 doses dose NNS cord-274141-vujx538o 417 15 of of IN cord-274141-vujx538o 417 16 500 500 CD cord-274141-vujx538o 417 17 and and CC cord-274141-vujx538o 417 18 1000 1000 CD cord-274141-vujx538o 417 19 mg mg NNP cord-274141-vujx538o 417 20 / / SYM cord-274141-vujx538o 417 21 day day NN cord-274141-vujx538o 417 22 for for IN cord-274141-vujx538o 417 23 12 12 CD cord-274141-vujx538o 417 24 weeks week NNS cord-274141-vujx538o 417 25 significantly significantly RB cord-274141-vujx538o 417 26 increased increase VBD cord-274141-vujx538o 417 27 plasma plasma NN cord-274141-vujx538o 417 28 quercetin quercetin NN cord-274141-vujx538o 417 29 levels level NNS cord-274141-vujx538o 417 30 with with IN cord-274141-vujx538o 417 31 no no DT cord-274141-vujx538o 417 32 reported report VBN cord-274141-vujx538o 417 33 side side NN cord-274141-vujx538o 417 34 effects effect NNS cord-274141-vujx538o 417 35 , , , cord-274141-vujx538o 417 36 but but CC cord-274141-vujx538o 417 37 neither neither CC cord-274141-vujx538o 417 38 decreased decrease VBD cord-274141-vujx538o 417 39 total total JJ cord-274141-vujx538o 417 40 number number NN cord-274141-vujx538o 417 41 of of IN cord-274141-vujx538o 417 42 upper upper JJ cord-274141-vujx538o 417 43 respiratory respiratory JJ cord-274141-vujx538o 417 44 tract tract NN cord-274141-vujx538o 417 45 infection infection NN cord-274141-vujx538o 418 1 sick sick JJ cord-274141-vujx538o 418 2 days day NNS cord-274141-vujx538o 418 3 nor nor CC cord-274141-vujx538o 418 4 reduced reduce VBN cord-274141-vujx538o 418 5 symptomatology symptomatology NN cord-274141-vujx538o 418 6 in in IN cord-274141-vujx538o 418 7 all all DT cord-274141-vujx538o 418 8 subjects subject NNS cord-274141-vujx538o 418 9 ( ( -LRB- cord-274141-vujx538o 418 10 Heinz Heinz NNP cord-274141-vujx538o 418 11 et et NNP cord-274141-vujx538o 418 12 al al NNP cord-274141-vujx538o 418 13 . . NNP cord-274141-vujx538o 418 14 2010 2010 CD cord-274141-vujx538o 418 15 ) ) -RRB- cord-274141-vujx538o 418 16 . . . cord-274141-vujx538o 419 1 Liu Liu NNP cord-274141-vujx538o 419 2 et et NNP cord-274141-vujx538o 419 3 al al NNP cord-274141-vujx538o 419 4 . . . cord-274141-vujx538o 420 1 ( ( -LRB- cord-274141-vujx538o 420 2 2012 2012 CD cord-274141-vujx538o 420 3 ) ) -RRB- cord-274141-vujx538o 420 4 reviewed review VBD cord-274141-vujx538o 420 5 12 12 CD cord-274141-vujx538o 420 6 randomized randomize VBN cord-274141-vujx538o 420 7 controlled control VBN cord-274141-vujx538o 420 8 trials trial NNS cord-274141-vujx538o 420 9 and and CC cord-274141-vujx538o 420 10 one one CD cord-274141-vujx538o 420 11 quasirandomized quasirandomized NN cord-274141-vujx538o 420 12 controlled control VBN cord-274141-vujx538o 420 13 trial trial NN cord-274141-vujx538o 420 14 where where WRB cord-274141-vujx538o 420 15 12 12 CD cord-274141-vujx538o 420 16 herbal herbal JJ cord-274141-vujx538o 420 17 remedies remedy NNS cord-274141-vujx538o 420 18 were be VBD cord-274141-vujx538o 420 19 administered administer VBN cord-274141-vujx538o 420 20 on on IN cord-274141-vujx538o 420 21 640 640 CD cord-274141-vujx538o 420 22 SARS SARS NNP cord-274141-vujx538o 420 23 patients patient NNS cord-274141-vujx538o 420 24 . . . cord-274141-vujx538o 421 1 Case case NN cord-274141-vujx538o 421 2 reports report NNS cord-274141-vujx538o 421 3 , , , cord-274141-vujx538o 421 4 case case NN cord-274141-vujx538o 421 5 series series NN cord-274141-vujx538o 421 6 , , , cord-274141-vujx538o 421 7 controlled control VBN cord-274141-vujx538o 421 8 observational observational JJ cord-274141-vujx538o 421 9 studies study NNS cord-274141-vujx538o 421 10 , , , cord-274141-vujx538o 421 11 and and CC cord-274141-vujx538o 421 12 randomized randomized JJ cord-274141-vujx538o 421 13 clinical clinical JJ cord-274141-vujx538o 421 14 trials trial NNS cord-274141-vujx538o 421 15 provided provide VBD cord-274141-vujx538o 421 16 compelling compelling JJ cord-274141-vujx538o 421 17 data datum NNS cord-274141-vujx538o 421 18 that that IN cord-274141-vujx538o 421 19 TCM TCM NNP cord-274141-vujx538o 421 20 had have VBD cord-274141-vujx538o 421 21 beneficial beneficial JJ cord-274141-vujx538o 421 22 effects effect NNS cord-274141-vujx538o 421 23 in in IN cord-274141-vujx538o 421 24 the the DT cord-274141-vujx538o 421 25 treatment treatment NN cord-274141-vujx538o 421 26 or or CC cord-274141-vujx538o 421 27 prevention prevention NN cord-274141-vujx538o 421 28 of of IN cord-274141-vujx538o 421 29 SARS SARS NNP cord-274141-vujx538o 422 1 ( ( -LRB- cord-274141-vujx538o 422 2 Lau Lau NNP cord-274141-vujx538o 422 3 et et NNP cord-274141-vujx538o 422 4 al al NNP cord-274141-vujx538o 422 5 . . NNP cord-274141-vujx538o 422 6 2005 2005 CD cord-274141-vujx538o 422 7 ) ) -RRB- cord-274141-vujx538o 422 8 . . . cord-274141-vujx538o 423 1 For for IN cord-274141-vujx538o 423 2 example example NN cord-274141-vujx538o 423 3 , , , cord-274141-vujx538o 423 4 the the DT cord-274141-vujx538o 423 5 rate rate NN cord-274141-vujx538o 423 6 of of IN cord-274141-vujx538o 423 7 fatality fatality NN cord-274141-vujx538o 423 8 in in IN cord-274141-vujx538o 423 9 Hong Hong NNP cord-274141-vujx538o 423 10 Kong Kong NNP cord-274141-vujx538o 423 11 and and CC cord-274141-vujx538o 423 12 Singapore Singapore NNP cord-274141-vujx538o 423 13 was be VBD cord-274141-vujx538o 423 14 approximately approximately RB cord-274141-vujx538o 423 15 18 18 CD cord-274141-vujx538o 423 16 % % NN cord-274141-vujx538o 423 17 , , , cord-274141-vujx538o 423 18 while while IN cord-274141-vujx538o 423 19 the the DT cord-274141-vujx538o 423 20 rate rate NN cord-274141-vujx538o 423 21 for for IN cord-274141-vujx538o 423 22 Beijing Beijing NNP cord-274141-vujx538o 423 23 was be VBD cord-274141-vujx538o 423 24 initially initially RB cord-274141-vujx538o 423 25 more more JJR cord-274141-vujx538o 423 26 than than IN cord-274141-vujx538o 423 27 52 52 CD cord-274141-vujx538o 423 28 % % NN cord-274141-vujx538o 423 29 until until IN cord-274141-vujx538o 423 30 the the DT cord-274141-vujx538o 423 31 5th 5th JJ cord-274141-vujx538o 423 32 May May NNP cord-274141-vujx538o 423 33 2003 2003 CD cord-274141-vujx538o 423 34 when when WRB cord-274141-vujx538o 423 35 it -PRON- PRP cord-274141-vujx538o 423 36 decreased decrease VBD cord-274141-vujx538o 423 37 to to IN cord-274141-vujx538o 423 38 4 4 CD cord-274141-vujx538o 423 39 % % NN cord-274141-vujx538o 423 40 , , , cord-274141-vujx538o 423 41 and and CC cord-274141-vujx538o 423 42 then then RB cord-274141-vujx538o 423 43 to to IN cord-274141-vujx538o 423 44 1 1 CD cord-274141-vujx538o 423 45 % % NN cord-274141-vujx538o 423 46 after after IN cord-274141-vujx538o 423 47 20th 20th JJ cord-274141-vujx538o 423 48 May May NNP cord-274141-vujx538o 423 49 2003 2003 CD cord-274141-vujx538o 423 50 . . . cord-274141-vujx538o 424 1 The the DT cord-274141-vujx538o 424 2 dramatic dramatic JJ cord-274141-vujx538o 424 3 reduction reduction NN cord-274141-vujx538o 424 4 in in IN cord-274141-vujx538o 424 5 fatality fatality NN cord-274141-vujx538o 424 6 in in IN cord-274141-vujx538o 424 7 Beijing Beijing NNP cord-274141-vujx538o 424 8 was be VBD cord-274141-vujx538o 424 9 associated associate VBN cord-274141-vujx538o 424 10 with with IN cord-274141-vujx538o 424 11 the the DT cord-274141-vujx538o 424 12 use use NN cord-274141-vujx538o 424 13 of of IN cord-274141-vujx538o 424 14 TCM TCM NNP cord-274141-vujx538o 424 15 as as IN cord-274141-vujx538o 424 16 a a DT cord-274141-vujx538o 424 17 supplement supplement NN cord-274141-vujx538o 424 18 to to IN cord-274141-vujx538o 424 19 conventional conventional JJ cord-274141-vujx538o 424 20 therapy therapy NN cord-274141-vujx538o 424 21 ( ( -LRB- cord-274141-vujx538o 424 22 Chen Chen NNP cord-274141-vujx538o 424 23 and and CC cord-274141-vujx538o 424 24 Nakamura Nakamura NNP cord-274141-vujx538o 424 25 2004 2004 CD cord-274141-vujx538o 424 26 ) ) -RRB- cord-274141-vujx538o 424 27 . . . cord-274141-vujx538o 425 1 Lau Lau NNP cord-274141-vujx538o 425 2 et et NNP cord-274141-vujx538o 425 3 al al NNP cord-274141-vujx538o 425 4 . . . cord-274141-vujx538o 426 1 ( ( -LRB- cord-274141-vujx538o 426 2 2005 2005 CD cord-274141-vujx538o 426 3 ) ) -RRB- cord-274141-vujx538o 426 4 reported report VBD cord-274141-vujx538o 426 5 that that IN cord-274141-vujx538o 426 6 during during IN cord-274141-vujx538o 426 7 the the DT cord-274141-vujx538o 426 8 SARS SARS NNP cord-274141-vujx538o 426 9 outbreak outbreak NN cord-274141-vujx538o 426 10 of of IN cord-274141-vujx538o 426 11 2002/2003 2002/2003 CD cord-274141-vujx538o 426 12 , , , cord-274141-vujx538o 426 13 1063 1063 CD cord-274141-vujx538o 426 14 volunteers volunteer NNS cord-274141-vujx538o 426 15 including include VBG cord-274141-vujx538o 426 16 926 926 CD cord-274141-vujx538o 426 17 hospital hospital NN cord-274141-vujx538o 426 18 workers worker NNS cord-274141-vujx538o 426 19 and and CC cord-274141-vujx538o 426 20 37 37 CD cord-274141-vujx538o 426 21 laboratory laboratory NN cord-274141-vujx538o 426 22 technicians technician NNS cord-274141-vujx538o 426 23 working work VBG cord-274141-vujx538o 426 24 in in IN cord-274141-vujx538o 426 25 high high JJ cord-274141-vujx538o 426 26 - - HYPH cord-274141-vujx538o 426 27 risk risk NN cord-274141-vujx538o 426 28 virus virus NN cord-274141-vujx538o 426 29 laboratories laboratory NNS cord-274141-vujx538o 426 30 used use VBD cord-274141-vujx538o 426 31 TCM TCM NNP cord-274141-vujx538o 426 32 , , , cord-274141-vujx538o 426 33 namely namely RB cord-274141-vujx538o 426 34 Sang sing VBD cord-274141-vujx538o 426 35 Ju Ju NNP cord-274141-vujx538o 426 36 Yin Yin NNP cord-274141-vujx538o 426 37 plus plus CC cord-274141-vujx538o 426 38 Yu Yu NNP cord-274141-vujx538o 426 39 Ping Ping NNP cord-274141-vujx538o 426 40 Feng Feng NNP cord-274141-vujx538o 426 41 San San NNP cord-274141-vujx538o 426 42 . . . cord-274141-vujx538o 427 1 Compared compare VBN cord-274141-vujx538o 427 2 with with IN cord-274141-vujx538o 427 3 the the DT cord-274141-vujx538o 427 4 0.4 0.4 CD cord-274141-vujx538o 427 5 % % NN cord-274141-vujx538o 427 6 of of IN cord-274141-vujx538o 427 7 infection infection NN cord-274141-vujx538o 427 8 in in IN cord-274141-vujx538o 427 9 the the DT cord-274141-vujx538o 427 10 placebo placebo NN cord-274141-vujx538o 427 11 group group NN cord-274141-vujx538o 427 12 , , , cord-274141-vujx538o 427 13 none none NN cord-274141-vujx538o 427 14 of of IN cord-274141-vujx538o 427 15 the the DT cord-274141-vujx538o 427 16 TCM TCM NNP cord-274141-vujx538o 427 17 users user NNS cord-274141-vujx538o 427 18 was be VBD cord-274141-vujx538o 427 19 infected infect VBN cord-274141-vujx538o 427 20 . . . cord-274141-vujx538o 428 1 In in IN cord-274141-vujx538o 428 2 a a DT cord-274141-vujx538o 428 3 controlled control VBN cord-274141-vujx538o 428 4 clinical clinical JJ cord-274141-vujx538o 428 5 study study NN cord-274141-vujx538o 428 6 , , , cord-274141-vujx538o 428 7 Hsu Hsu NNP cord-274141-vujx538o 428 8 et et NNP cord-274141-vujx538o 428 9 al al NNP cord-274141-vujx538o 428 10 . . . cord-274141-vujx538o 429 1 ( ( -LRB- cord-274141-vujx538o 429 2 2006b 2006b CD cord-274141-vujx538o 429 3 ) ) -RRB- cord-274141-vujx538o 429 4 reported report VBD cord-274141-vujx538o 429 5 that that IN cord-274141-vujx538o 429 6 supplementary supplementary JJ cord-274141-vujx538o 429 7 treatment treatment NN cord-274141-vujx538o 429 8 with with IN cord-274141-vujx538o 429 9 TCM TCM NNP cord-274141-vujx538o 429 10 resulted result VBD cord-274141-vujx538o 429 11 in in IN cord-274141-vujx538o 429 12 marked marked JJ cord-274141-vujx538o 429 13 relief relief NN cord-274141-vujx538o 429 14 of of IN cord-274141-vujx538o 429 15 symptoms symptom NNS cord-274141-vujx538o 429 16 and and CC cord-274141-vujx538o 429 17 truncated truncate VBD cord-274141-vujx538o 429 18 the the DT cord-274141-vujx538o 429 19 disease disease NN cord-274141-vujx538o 429 20 course course NN cord-274141-vujx538o 429 21 . . . cord-274141-vujx538o 430 1 The the DT cord-274141-vujx538o 430 2 clinical clinical JJ cord-274141-vujx538o 430 3 benefits benefit NNS cord-274141-vujx538o 430 4 of of IN cord-274141-vujx538o 430 5 TCM TCM NNP cord-274141-vujx538o 430 6 were be VBD cord-274141-vujx538o 430 7 supported support VBN cord-274141-vujx538o 430 8 by by IN cord-274141-vujx538o 430 9 laboratory laboratory NN cord-274141-vujx538o 430 10 studies study NNS cord-274141-vujx538o 430 11 especially especially RB cord-274141-vujx538o 430 12 for for IN cord-274141-vujx538o 430 13 the the DT cord-274141-vujx538o 430 14 use use NN cord-274141-vujx538o 430 15 of of IN cord-274141-vujx538o 430 16 glycyrrhizin glycyrrhizin NNP cord-274141-vujx538o 430 17 ( ( -LRB- cord-274141-vujx538o 430 18 5 5 CD cord-274141-vujx538o 430 19 ) ) -RRB- cord-274141-vujx538o 430 20 , , , cord-274141-vujx538o 430 21 baicalin baicalin NNP cord-274141-vujx538o 430 22 ( ( -LRB- cord-274141-vujx538o 430 23 10 10 CD cord-274141-vujx538o 430 24 ) ) -RRB- cord-274141-vujx538o 430 25 , , , cord-274141-vujx538o 430 26 and and CC cord-274141-vujx538o 430 27 MOL376 MOL376 NNP cord-274141-vujx538o 430 28 , , , cord-274141-vujx538o 430 29 an an DT cord-274141-vujx538o 430 30 inhibitor inhibitor NN cord-274141-vujx538o 430 31 of of IN cord-274141-vujx538o 430 32 cathepsin cathepsin NN cord-274141-vujx538o 430 33 L l NN cord-274141-vujx538o 430 34 that that WDT cord-274141-vujx538o 430 35 could could MD cord-274141-vujx538o 430 36 become become VB cord-274141-vujx538o 430 37 a a DT cord-274141-vujx538o 430 38 lead lead JJ cord-274141-vujx538o 430 39 compound compound NN cord-274141-vujx538o 430 40 for for IN cord-274141-vujx538o 430 41 SARS SARS NNP cord-274141-vujx538o 430 42 therapy therapy NN cord-274141-vujx538o 430 43 . . . cord-274141-vujx538o 431 1 After after IN cord-274141-vujx538o 431 2 a a DT cord-274141-vujx538o 431 3 review review NN cord-274141-vujx538o 431 4 of of IN cord-274141-vujx538o 431 5 eight eight CD cord-274141-vujx538o 431 6 randomized randomized JJ cord-274141-vujx538o 431 7 controlled control VBN cord-274141-vujx538o 431 8 trials trial NNS cord-274141-vujx538o 431 9 , , , cord-274141-vujx538o 431 10 Liu Liu NNP cord-274141-vujx538o 431 11 et et NNP cord-274141-vujx538o 431 12 al al NNP cord-274141-vujx538o 431 13 . . . cord-274141-vujx538o 432 1 ( ( -LRB- cord-274141-vujx538o 432 2 2004 2004 CD cord-274141-vujx538o 432 3 ) ) -RRB- cord-274141-vujx538o 432 4 resolved resolve VBD cord-274141-vujx538o 432 5 that that IN cord-274141-vujx538o 432 6 a a DT cord-274141-vujx538o 432 7 combination combination NN cord-274141-vujx538o 432 8 of of IN cord-274141-vujx538o 432 9 TCM TCM NNP cord-274141-vujx538o 432 10 with with IN cord-274141-vujx538o 432 11 conventional conventional JJ cord-274141-vujx538o 432 12 medicine medicine NN cord-274141-vujx538o 432 13 had have VBD cord-274141-vujx538o 432 14 beneficial beneficial JJ cord-274141-vujx538o 432 15 effects effect NNS cord-274141-vujx538o 432 16 such such JJ cord-274141-vujx538o 432 17 as as IN cord-274141-vujx538o 432 18 decrease decrease NN cord-274141-vujx538o 432 19 of of IN cord-274141-vujx538o 432 20 mortality mortality NN cord-274141-vujx538o 432 21 , , , cord-274141-vujx538o 432 22 relief relief NN cord-274141-vujx538o 432 23 of of IN cord-274141-vujx538o 432 24 symptoms symptom NNS cord-274141-vujx538o 432 25 , , , cord-274141-vujx538o 432 26 and and CC cord-274141-vujx538o 432 27 control control NN cord-274141-vujx538o 432 28 of of IN cord-274141-vujx538o 432 29 fungal fungal JJ cord-274141-vujx538o 432 30 infections infection NNS cord-274141-vujx538o 432 31 in in IN cord-274141-vujx538o 432 32 patients patient NNS cord-274141-vujx538o 432 33 with with IN cord-274141-vujx538o 432 34 SARS SARS NNP cord-274141-vujx538o 432 35 . . . cord-274141-vujx538o 433 1 However however RB cord-274141-vujx538o 433 2 , , , cord-274141-vujx538o 433 3 the the DT cord-274141-vujx538o 433 4 trial trial NN cord-274141-vujx538o 433 5 evidence evidence NN cord-274141-vujx538o 433 6 was be VBD cord-274141-vujx538o 433 7 not not RB cord-274141-vujx538o 433 8 sufficient sufficient JJ cord-274141-vujx538o 433 9 enough enough RB cord-274141-vujx538o 433 10 due due IN cord-274141-vujx538o 433 11 to to IN cord-274141-vujx538o 433 12 the the DT cord-274141-vujx538o 433 13 lack lack NN cord-274141-vujx538o 433 14 of of IN cord-274141-vujx538o 433 15 methodological methodological JJ cord-274141-vujx538o 433 16 rigour rigour NN cord-274141-vujx538o 433 17 . . . cord-274141-vujx538o 434 1 In in IN cord-274141-vujx538o 434 2 a a DT cord-274141-vujx538o 434 3 review review NN cord-274141-vujx538o 434 4 of of IN cord-274141-vujx538o 434 5 90 90 CD cord-274141-vujx538o 434 6 peer peer NN cord-274141-vujx538o 434 7 - - HYPH cord-274141-vujx538o 434 8 reviewed review VBN cord-274141-vujx538o 434 9 Chinese chinese JJ cord-274141-vujx538o 434 10 publications publication NNS cord-274141-vujx538o 434 11 after after IN cord-274141-vujx538o 434 12 the the DT cord-274141-vujx538o 434 13 SARS SARS NNP cord-274141-vujx538o 434 14 epidemic epidemic NN cord-274141-vujx538o 434 15 of of IN cord-274141-vujx538o 434 16 2002 2002 CD cord-274141-vujx538o 434 17 , , , cord-274141-vujx538o 434 18 Leung Leung NNP cord-274141-vujx538o 434 19 ( ( -LRB- cord-274141-vujx538o 434 20 2007 2007 CD cord-274141-vujx538o 434 21 concluded conclude VBD cord-274141-vujx538o 434 22 that that IN cord-274141-vujx538o 434 23 TCM TCM NNP cord-274141-vujx538o 434 24 used use VBN cord-274141-vujx538o 434 25 together together RB cord-274141-vujx538o 434 26 with with IN cord-274141-vujx538o 434 27 conventional conventional JJ cord-274141-vujx538o 434 28 treatment treatment NN cord-274141-vujx538o 434 29 had have VBD cord-274141-vujx538o 434 30 positive positive JJ cord-274141-vujx538o 434 31 effects effect NNS cord-274141-vujx538o 434 32 including include VBG cord-274141-vujx538o 434 33 better well JJR cord-274141-vujx538o 434 34 control control NN cord-274141-vujx538o 434 35 of of IN cord-274141-vujx538o 434 36 fever fever NN cord-274141-vujx538o 434 37 and and CC cord-274141-vujx538o 434 38 quicker quick JJR cord-274141-vujx538o 434 39 amelioration amelioration NN cord-274141-vujx538o 434 40 of of IN cord-274141-vujx538o 434 41 chest chest NN cord-274141-vujx538o 434 42 infection infection NN cord-274141-vujx538o 434 43 . . . cord-274141-vujx538o 435 1 Wu Wu NNP cord-274141-vujx538o 435 2 et et NNP cord-274141-vujx538o 435 3 al al NNP cord-274141-vujx538o 435 4 . . . cord-274141-vujx538o 436 1 ( ( -LRB- cord-274141-vujx538o 436 2 2008 2008 CD cord-274141-vujx538o 436 3 ) ) -RRB- cord-274141-vujx538o 436 4 urged urge VBD cord-274141-vujx538o 436 5 a a DT cord-274141-vujx538o 436 6 rerun rerun NN cord-274141-vujx538o 436 7 of of IN cord-274141-vujx538o 436 8 clinical clinical JJ cord-274141-vujx538o 436 9 trials trial NNS cord-274141-vujx538o 436 10 involving involve VBG cord-274141-vujx538o 436 11 TCM TCM NNP cord-274141-vujx538o 436 12 for for IN cord-274141-vujx538o 436 13 the the DT cord-274141-vujx538o 436 14 treatment treatment NN cord-274141-vujx538o 436 15 of of IN cord-274141-vujx538o 436 16 SARS SARS NNP cord-274141-vujx538o 436 17 because because IN cord-274141-vujx538o 436 18 the the DT cord-274141-vujx538o 436 19 validity validity NN cord-274141-vujx538o 436 20 of of IN cord-274141-vujx538o 436 21 results result NNS cord-274141-vujx538o 436 22 was be VBD cord-274141-vujx538o 436 23 jeopardized jeopardize VBN cord-274141-vujx538o 436 24 by by IN cord-274141-vujx538o 436 25 questionable questionable JJ cord-274141-vujx538o 436 26 trial trial NN cord-274141-vujx538o 436 27 designs design NNS cord-274141-vujx538o 436 28 and and CC cord-274141-vujx538o 436 29 experimental experimental JJ cord-274141-vujx538o 436 30 biases bias NNS cord-274141-vujx538o 436 31 . . . cord-274141-vujx538o 437 1 TCM TCM NNP cord-274141-vujx538o 437 2 should should MD cord-274141-vujx538o 437 3 be be VB cord-274141-vujx538o 437 4 evaluated evaluate VBN cord-274141-vujx538o 437 5 in in IN cord-274141-vujx538o 437 6 carefully carefully RB cord-274141-vujx538o 437 7 designed design VBN cord-274141-vujx538o 437 8 clinical clinical JJ cord-274141-vujx538o 437 9 trials trial NNS cord-274141-vujx538o 437 10 , , , cord-274141-vujx538o 437 11 either either CC cord-274141-vujx538o 437 12 used use VBN cord-274141-vujx538o 437 13 alone alone RB cord-274141-vujx538o 437 14 or or CC cord-274141-vujx538o 437 15 integrated integrate VBN cord-274141-vujx538o 437 16 with with IN cord-274141-vujx538o 437 17 Western western JJ cord-274141-vujx538o 437 18 medicine medicine NN cord-274141-vujx538o 437 19 , , , cord-274141-vujx538o 437 20 to to TO cord-274141-vujx538o 437 21 cover cover VB cord-274141-vujx538o 437 22 the the DT cord-274141-vujx538o 437 23 prevention prevention NN cord-274141-vujx538o 437 24 and and CC cord-274141-vujx538o 437 25 treatment treatment NN cord-274141-vujx538o 437 26 of of IN cord-274141-vujx538o 437 27 patients patient NNS cord-274141-vujx538o 437 28 suffering suffer VBG cord-274141-vujx538o 437 29 from from IN cord-274141-vujx538o 437 30 COVID-19 COVID-19 NNP cord-274141-vujx538o 437 31 pneumonia pneumonia NN cord-274141-vujx538o 437 32 ( ( -LRB- cord-274141-vujx538o 437 33 Ling Ling NNP cord-274141-vujx538o 437 34 2020 2020 CD cord-274141-vujx538o 437 35 ) ) -RRB- cord-274141-vujx538o 437 36 . . . cord-274141-vujx538o 438 1 By by IN cord-274141-vujx538o 438 2 mid mid NNP cord-274141-vujx538o 438 3 - - NNP cord-274141-vujx538o 438 4 March March NNP cord-274141-vujx538o 438 5 2020 2020 CD cord-274141-vujx538o 438 6 , , , cord-274141-vujx538o 438 7 at at IN cord-274141-vujx538o 438 8 least least RBS cord-274141-vujx538o 438 9 14 14 CD cord-274141-vujx538o 438 10 TCM TCM NNP cord-274141-vujx538o 438 11 clinical clinical JJ cord-274141-vujx538o 438 12 trials trial NNS cord-274141-vujx538o 438 13 with with IN cord-274141-vujx538o 438 14 a a DT cord-274141-vujx538o 438 15 total total NN cord-274141-vujx538o 438 16 of of IN cord-274141-vujx538o 438 17 2714 2714 CD cord-274141-vujx538o 438 18 patients patient NNS cord-274141-vujx538o 438 19 were be VBD cord-274141-vujx538o 438 20 ongoing ongoing JJ cord-274141-vujx538o 438 21 for for IN cord-274141-vujx538o 438 22 the the DT cord-274141-vujx538o 438 23 treatment treatment NN cord-274141-vujx538o 438 24 of of IN cord-274141-vujx538o 438 25 SARS SARS NNP cord-274141-vujx538o 438 26 - - HYPH cord-274141-vujx538o 438 27 CoV-2 CoV-2 NNP cord-274141-vujx538o 438 28 infection infection NN cord-274141-vujx538o 438 29 . . . cord-274141-vujx538o 439 1 Chinese chinese JJ cord-274141-vujx538o 439 2 treatment treatment NN cord-274141-vujx538o 439 3 data datum NNS cord-274141-vujx538o 439 4 showed show VBD cord-274141-vujx538o 439 5 that that IN cord-274141-vujx538o 439 6 patented patent VBN cord-274141-vujx538o 439 7 TCM TCM NNP cord-274141-vujx538o 439 8 had have VBD cord-274141-vujx538o 439 9 good good JJ cord-274141-vujx538o 439 10 therapeutic therapeutic JJ cord-274141-vujx538o 439 11 efficacy efficacy NN cord-274141-vujx538o 439 12 in in IN cord-274141-vujx538o 439 13 the the DT cord-274141-vujx538o 439 14 treatment treatment NN cord-274141-vujx538o 439 15 of of IN cord-274141-vujx538o 439 16 COVID-19 COVID-19 NNP cord-274141-vujx538o 439 17 , , , cord-274141-vujx538o 439 18 with with IN cord-274141-vujx538o 439 19 minimal minimal JJ cord-274141-vujx538o 439 20 adverse adverse JJ cord-274141-vujx538o 439 21 reactions reaction NNS cord-274141-vujx538o 439 22 ( ( -LRB- cord-274141-vujx538o 439 23 Zhuang Zhuang NNP cord-274141-vujx538o 439 24 et et NNP cord-274141-vujx538o 439 25 al al NNP cord-274141-vujx538o 439 26 . . NNP cord-274141-vujx538o 439 27 2020 2020 CD cord-274141-vujx538o 439 28 ) ) -RRB- cord-274141-vujx538o 439 29 . . . cord-274141-vujx538o 440 1 Empirical empirical JJ cord-274141-vujx538o 440 2 data datum NNS cord-274141-vujx538o 440 3 on on IN cord-274141-vujx538o 440 4 SARS SARS NNP cord-274141-vujx538o 440 5 - - HYPH cord-274141-vujx538o 440 6 CoV cov NN cord-274141-vujx538o 440 7 treatments treatment NNS cord-274141-vujx538o 440 8 are be VBP cord-274141-vujx538o 440 9 scarce scarce JJ cord-274141-vujx538o 440 10 ( ( -LRB- cord-274141-vujx538o 440 11 Wong Wong NNP cord-274141-vujx538o 440 12 and and CC cord-274141-vujx538o 440 13 Yuen Yuen NNP cord-274141-vujx538o 440 14 2008 2008 CD cord-274141-vujx538o 440 15 ) ) -RRB- cord-274141-vujx538o 440 16 , , , cord-274141-vujx538o 440 17 and and CC cord-274141-vujx538o 440 18 the the DT cord-274141-vujx538o 440 19 majority majority NN cord-274141-vujx538o 440 20 of of IN cord-274141-vujx538o 440 21 viral viral JJ cord-274141-vujx538o 440 22 diseases disease NNS cord-274141-vujx538o 440 23 do do VBP cord-274141-vujx538o 440 24 not not RB cord-274141-vujx538o 440 25 have have VB cord-274141-vujx538o 440 26 targeted target VBN cord-274141-vujx538o 440 27 drugs drug NNS cord-274141-vujx538o 440 28 or or CC cord-274141-vujx538o 440 29 vaccines vaccine NNS cord-274141-vujx538o 440 30 ( ( -LRB- cord-274141-vujx538o 440 31 Mahapatra Mahapatra NNP cord-274141-vujx538o 440 32 et et NNP cord-274141-vujx538o 440 33 al al NNP cord-274141-vujx538o 440 34 . . . cord-274141-vujx538o 440 35 2019 2019 CD cord-274141-vujx538o 440 36 ) ) -RRB- cord-274141-vujx538o 440 37 . . . cord-274141-vujx538o 441 1 Although although IN cord-274141-vujx538o 441 2 the the DT cord-274141-vujx538o 441 3 ongoing ongoing JJ cord-274141-vujx538o 441 4 SARS SARS NNP cord-274141-vujx538o 441 5 - - HYPH cord-274141-vujx538o 441 6 CoV-2 CoV-2 NNP cord-274141-vujx538o 441 7 global global JJ cord-274141-vujx538o 441 8 pandemic pandemic NN cord-274141-vujx538o 441 9 should should MD cord-274141-vujx538o 441 10 remind remind VB cord-274141-vujx538o 441 11 scientists scientist NNS cord-274141-vujx538o 441 12 that that IN cord-274141-vujx538o 441 13 current current JJ cord-274141-vujx538o 441 14 options option NNS cord-274141-vujx538o 441 15 for for IN cord-274141-vujx538o 441 16 treating treat VBG cord-274141-vujx538o 441 17 life life NN cord-274141-vujx538o 441 18 - - HYPH cord-274141-vujx538o 441 19 threatening threaten VBG cord-274141-vujx538o 441 20 zoonotic zoonotic JJ cord-274141-vujx538o 441 21 coronavirus coronavirus NN cord-274141-vujx538o 441 22 infections infection NNS cord-274141-vujx538o 441 23 are be VBP cord-274141-vujx538o 441 24 very very RB cord-274141-vujx538o 441 25 limited limited JJ cord-274141-vujx538o 441 26 , , , cord-274141-vujx538o 441 27 medicinal medicinal JJ cord-274141-vujx538o 441 28 plants plant NNS cord-274141-vujx538o 441 29 offer offer VBP cord-274141-vujx538o 441 30 a a DT cord-274141-vujx538o 441 31 strong strong JJ cord-274141-vujx538o 441 32 pipeline pipeline NN cord-274141-vujx538o 441 33 for for IN cord-274141-vujx538o 441 34 the the DT cord-274141-vujx538o 441 35 discovery discovery NN cord-274141-vujx538o 441 36 of of IN cord-274141-vujx538o 441 37 novel novel JJ cord-274141-vujx538o 441 38 lead lead NN cord-274141-vujx538o 441 39 compounds compound NNS cord-274141-vujx538o 441 40 that that WDT cord-274141-vujx538o 441 41 can can MD cord-274141-vujx538o 441 42 be be VB cord-274141-vujx538o 441 43 converted convert VBN cord-274141-vujx538o 441 44 into into IN cord-274141-vujx538o 441 45 new new JJ cord-274141-vujx538o 441 46 drugs drug NNS cord-274141-vujx538o 441 47 to to TO cord-274141-vujx538o 441 48 treat treat VB cord-274141-vujx538o 441 49 COVID-19 COVID-19 NNP cord-274141-vujx538o 441 50 . . . cord-274141-vujx538o 442 1 Medicinal medicinal JJ cord-274141-vujx538o 442 2 plants plant NNS cord-274141-vujx538o 442 3 hold hold VBP cord-274141-vujx538o 442 4 great great JJ cord-274141-vujx538o 442 5 promise promise NN cord-274141-vujx538o 442 6 for for IN cord-274141-vujx538o 442 7 drug drug NN cord-274141-vujx538o 442 8 development development NN cord-274141-vujx538o 442 9 against against IN cord-274141-vujx538o 442 10 SARS SARS NNP cord-274141-vujx538o 442 11 - - HYPH cord-274141-vujx538o 442 12 CoV-2 CoV-2 NNP cord-274141-vujx538o 442 13 , , , cord-274141-vujx538o 442 14 but but CC cord-274141-vujx538o 442 15 there there EX cord-274141-vujx538o 442 16 is be VBZ cord-274141-vujx538o 442 17 paucity paucity NN cord-274141-vujx538o 442 18 of of IN cord-274141-vujx538o 442 19 research research NN cord-274141-vujx538o 442 20 on on IN cord-274141-vujx538o 442 21 the the DT cord-274141-vujx538o 442 22 development development NN cord-274141-vujx538o 442 23 of of IN cord-274141-vujx538o 442 24 anti anti JJ cord-274141-vujx538o 442 25 - - JJ cord-274141-vujx538o 442 26 SARS SARS NNP cord-274141-vujx538o 442 27 - - HYPH cord-274141-vujx538o 442 28 CoV-2 CoV-2 NNP cord-274141-vujx538o 442 29 drugs drug NNS cord-274141-vujx538o 442 30 from from IN cord-274141-vujx538o 442 31 natural natural JJ cord-274141-vujx538o 442 32 products product NNS cord-274141-vujx538o 442 33 . . . cord-274141-vujx538o 443 1 In in IN cord-274141-vujx538o 443 2 addition addition NN cord-274141-vujx538o 443 3 , , , cord-274141-vujx538o 443 4 most most JJS cord-274141-vujx538o 443 5 of of IN cord-274141-vujx538o 443 6 the the DT cord-274141-vujx538o 443 7 data datum NNS cord-274141-vujx538o 443 8 on on IN cord-274141-vujx538o 443 9 natural natural JJ cord-274141-vujx538o 443 10 products product NNS cord-274141-vujx538o 443 11 with with IN cord-274141-vujx538o 443 12 activity activity NN cord-274141-vujx538o 443 13 against against IN cord-274141-vujx538o 443 14 HCoVs HCoVs NNP cord-274141-vujx538o 443 15 are be VBP cord-274141-vujx538o 443 16 from from IN cord-274141-vujx538o 443 17 non non JJ cord-274141-vujx538o 443 18 - - JJ cord-274141-vujx538o 443 19 clinical clinical JJ cord-274141-vujx538o 443 20 and and CC cord-274141-vujx538o 443 21 pre pre JJ cord-274141-vujx538o 443 22 - - JJ cord-274141-vujx538o 443 23 clinical clinical JJ cord-274141-vujx538o 443 24 studies study NNS cord-274141-vujx538o 443 25 . . . cord-274141-vujx538o 444 1 Potential potential JJ cord-274141-vujx538o 444 2 anti anti JJ cord-274141-vujx538o 444 3 - - JJ cord-274141-vujx538o 444 4 coronavirus coronavirus JJ cord-274141-vujx538o 444 5 therapies therapy NNS cord-274141-vujx538o 444 6 can can MD cord-274141-vujx538o 444 7 be be VB cord-274141-vujx538o 444 8 divided divide VBN cord-274141-vujx538o 444 9 into into IN cord-274141-vujx538o 444 10 two two CD cord-274141-vujx538o 444 11 categories category NNS cord-274141-vujx538o 444 12 depending depend VBG cord-274141-vujx538o 444 13 on on IN cord-274141-vujx538o 444 14 their -PRON- PRP$ cord-274141-vujx538o 444 15 target target NN cord-274141-vujx538o 444 16 : : : cord-274141-vujx538o 444 17 those those DT cord-274141-vujx538o 444 18 that that WDT cord-274141-vujx538o 444 19 act act VBP cord-274141-vujx538o 444 20 on on IN cord-274141-vujx538o 444 21 the the DT cord-274141-vujx538o 444 22 human human JJ cord-274141-vujx538o 444 23 immune immune JJ cord-274141-vujx538o 444 24 system system NN cord-274141-vujx538o 444 25 or or CC cord-274141-vujx538o 444 26 human human JJ cord-274141-vujx538o 444 27 cells cell NNS cord-274141-vujx538o 444 28 , , , cord-274141-vujx538o 444 29 and and CC cord-274141-vujx538o 444 30 those those DT cord-274141-vujx538o 444 31 that that WDT cord-274141-vujx538o 444 32 interfere interfere VBP cord-274141-vujx538o 444 33 with with IN cord-274141-vujx538o 444 34 the the DT cord-274141-vujx538o 444 35 coronavirus coronavirus NN cord-274141-vujx538o 444 36 itself -PRON- PRP cord-274141-vujx538o 444 37 . . . cord-274141-vujx538o 445 1 The the DT cord-274141-vujx538o 445 2 unmet unmet JJ cord-274141-vujx538o 445 3 need need NN cord-274141-vujx538o 445 4 for for IN cord-274141-vujx538o 445 5 pharmacologically pharmacologically RB cord-274141-vujx538o 445 6 potent potent JJ cord-274141-vujx538o 445 7 and and CC cord-274141-vujx538o 445 8 safe safe JJ cord-274141-vujx538o 445 9 antivirals antiviral NNS cord-274141-vujx538o 445 10 ought ought MD cord-274141-vujx538o 445 11 to to TO cord-274141-vujx538o 445 12 be be VB cord-274141-vujx538o 445 13 fulfilled fulfil VBN cord-274141-vujx538o 445 14 by by IN cord-274141-vujx538o 445 15 thinking think VBG cord-274141-vujx538o 445 16 out out IN cord-274141-vujx538o 445 17 of of IN cord-274141-vujx538o 445 18 the the DT cord-274141-vujx538o 445 19 box box NN cord-274141-vujx538o 445 20 and and CC cord-274141-vujx538o 445 21 indigenous indigenous JJ cord-274141-vujx538o 445 22 knowledge knowledge NN cord-274141-vujx538o 445 23 of of IN cord-274141-vujx538o 445 24 medicinal medicinal JJ cord-274141-vujx538o 445 25 plants plant NNS cord-274141-vujx538o 445 26 may may MD cord-274141-vujx538o 445 27 be be VB cord-274141-vujx538o 445 28 a a DT cord-274141-vujx538o 445 29 masterstroke masterstroke NN cord-274141-vujx538o 445 30 against against IN cord-274141-vujx538o 445 31 deadly deadly JJ cord-274141-vujx538o 445 32 infectious infectious JJ cord-274141-vujx538o 445 33 diseases disease NNS cord-274141-vujx538o 445 34 such such JJ cord-274141-vujx538o 445 35 as as IN cord-274141-vujx538o 445 36 COVID-19 COVID-19 NNP cord-274141-vujx538o 445 37 ( ( -LRB- cord-274141-vujx538o 445 38 Mahapatra Mahapatra NNP cord-274141-vujx538o 445 39 et et NNP cord-274141-vujx538o 445 40 al al NNP cord-274141-vujx538o 445 41 . . . cord-274141-vujx538o 445 42 2019 2019 CD cord-274141-vujx538o 445 43 ) ) -RRB- cord-274141-vujx538o 445 44 . . . cord-274141-vujx538o 446 1 Vellingiri Vellingiri NNP cord-274141-vujx538o 446 2 et et NNP cord-274141-vujx538o 446 3 al al NNP cord-274141-vujx538o 446 4 . . . cord-274141-vujx538o 447 1 ( ( -LRB- cord-274141-vujx538o 447 2 2020 2020 CD cord-274141-vujx538o 447 3 ) ) -RRB- cord-274141-vujx538o 447 4 postulated postulate VBD cord-274141-vujx538o 447 5 that that IN cord-274141-vujx538o 447 6 medicinal medicinal JJ cord-274141-vujx538o 447 7 plants plant NNS cord-274141-vujx538o 447 8 are be VBP cord-274141-vujx538o 447 9 potential potential JJ cord-274141-vujx538o 447 10 sources source NNS cord-274141-vujx538o 447 11 of of IN cord-274141-vujx538o 447 12 drugs drug NNS cord-274141-vujx538o 447 13 for for IN cord-274141-vujx538o 447 14 the the DT cord-274141-vujx538o 447 15 treatment treatment NN cord-274141-vujx538o 447 16 of of IN cord-274141-vujx538o 447 17 COVID-19 COVID-19 NNP cord-274141-vujx538o 447 18 . . . cord-274141-vujx538o 448 1 Ling Ling NNP cord-274141-vujx538o 448 2 ( ( -LRB- cord-274141-vujx538o 448 3 2020 2020 CD cord-274141-vujx538o 448 4 ) ) -RRB- cord-274141-vujx538o 448 5 also also RB cord-274141-vujx538o 448 6 submitted submit VBD cord-274141-vujx538o 448 7 that that IN cord-274141-vujx538o 448 8 traditional traditional JJ cord-274141-vujx538o 448 9 plant plant NN cord-274141-vujx538o 448 10 medicines medicine NNS cord-274141-vujx538o 448 11 are be VBP cord-274141-vujx538o 448 12 a a DT cord-274141-vujx538o 448 13 good good JJ cord-274141-vujx538o 448 14 source source NN cord-274141-vujx538o 448 15 of of IN cord-274141-vujx538o 448 16 natural natural JJ cord-274141-vujx538o 448 17 compounds compound NNS cord-274141-vujx538o 448 18 for for IN cord-274141-vujx538o 448 19 the the DT cord-274141-vujx538o 448 20 discovery discovery NN cord-274141-vujx538o 448 21 and and CC cord-274141-vujx538o 448 22 development development NN cord-274141-vujx538o 448 23 of of IN cord-274141-vujx538o 448 24 drugs drug NNS cord-274141-vujx538o 448 25 against against IN cord-274141-vujx538o 448 26 SARS SARS NNP cord-274141-vujx538o 448 27 - - HYPH cord-274141-vujx538o 448 28 CoV-2 CoV-2 NNP cord-274141-vujx538o 448 29 . . . cord-274141-vujx538o 449 1 So so RB cord-274141-vujx538o 449 2 , , , cord-274141-vujx538o 449 3 the the DT cord-274141-vujx538o 449 4 mortality mortality NN cord-274141-vujx538o 449 5 of of IN cord-274141-vujx538o 449 6 COVID-19 covid-19 JJ cord-274141-vujx538o 449 7 patients patient NNS cord-274141-vujx538o 449 8 in in IN cord-274141-vujx538o 449 9 China China NNP cord-274141-vujx538o 449 10 was be VBD cord-274141-vujx538o 449 11 limited limit VBN cord-274141-vujx538o 449 12 by by IN cord-274141-vujx538o 449 13 the the DT cord-274141-vujx538o 449 14 use use NN cord-274141-vujx538o 449 15 of of IN cord-274141-vujx538o 449 16 TCM TCM NNP cord-274141-vujx538o 449 17 . . . cord-274141-vujx538o 450 1 As as IN cord-274141-vujx538o 450 2 the the DT cord-274141-vujx538o 450 3 growing grow VBG cord-274141-vujx538o 450 4 COVID-19 covid-19 JJ cord-274141-vujx538o 450 5 global global JJ cord-274141-vujx538o 450 6 pandemic pandemic NN cord-274141-vujx538o 450 7 reformats reformat VBZ cord-274141-vujx538o 450 8 the the DT cord-274141-vujx538o 450 9 classical classical JJ cord-274141-vujx538o 450 10 norms norm NNS cord-274141-vujx538o 450 11 of of IN cord-274141-vujx538o 450 12 pharmaceutical pharmaceutical JJ cord-274141-vujx538o 450 13 and and CC cord-274141-vujx538o 450 14 clinical clinical JJ cord-274141-vujx538o 450 15 interventions intervention NNS cord-274141-vujx538o 450 16 , , , cord-274141-vujx538o 450 17 this this DT cord-274141-vujx538o 450 18 review review NN cord-274141-vujx538o 450 19 is be VBZ cord-274141-vujx538o 450 20 a a DT cord-274141-vujx538o 450 21 poignant poignant JJ cord-274141-vujx538o 450 22 reminder reminder NN cord-274141-vujx538o 450 23 that that IN cord-274141-vujx538o 450 24 repurposing repurposing NN cord-274141-vujx538o 450 25 of of IN cord-274141-vujx538o 450 26 current current JJ cord-274141-vujx538o 450 27 medicinal medicinal JJ cord-274141-vujx538o 450 28 plants plant NNS cord-274141-vujx538o 450 29 and and CC cord-274141-vujx538o 450 30 other other JJ cord-274141-vujx538o 450 31 natural natural JJ cord-274141-vujx538o 450 32 products product NNS cord-274141-vujx538o 450 33 to to TO cord-274141-vujx538o 450 34 treat treat VB cord-274141-vujx538o 450 35 COVID-19 COVID-19 NNP cord-274141-vujx538o 450 36 should should MD cord-274141-vujx538o 450 37 become become VB cord-274141-vujx538o 450 38 part part NN cord-274141-vujx538o 450 39 of of IN cord-274141-vujx538o 450 40 our -PRON- PRP$ cord-274141-vujx538o 450 41 new new JJ cord-274141-vujx538o 450 42 vernacular vernacular JJ cord-274141-vujx538o 450 43 health health NN cord-274141-vujx538o 450 44 system system NN cord-274141-vujx538o 450 45 . . . cord-274141-vujx538o 451 1 Comparative comparative JJ cord-274141-vujx538o 451 2 genomics genomic NNS cord-274141-vujx538o 451 3 lends lend VBZ cord-274141-vujx538o 451 4 credence credence NN cord-274141-vujx538o 451 5 to to IN cord-274141-vujx538o 451 6 the the DT cord-274141-vujx538o 451 7 repurposing repurposing NN cord-274141-vujx538o 451 8 of of IN cord-274141-vujx538o 451 9 current current JJ cord-274141-vujx538o 451 10 anti anti JJ cord-274141-vujx538o 451 11 - - JJ cord-274141-vujx538o 451 12 SARS sars JJ cord-274141-vujx538o 451 13 natural natural JJ cord-274141-vujx538o 451 14 products product NNS cord-274141-vujx538o 451 15 for for IN cord-274141-vujx538o 451 16 the the DT cord-274141-vujx538o 451 17 treatment treatment NN cord-274141-vujx538o 451 18 of of IN cord-274141-vujx538o 451 19 COVID-19 COVID-19 NNP cord-274141-vujx538o 451 20 . . . cord-274141-vujx538o 452 1 This this DT cord-274141-vujx538o 452 2 is be VBZ cord-274141-vujx538o 452 3 because because IN cord-274141-vujx538o 452 4 the the DT cord-274141-vujx538o 452 5 genome genome NN cord-274141-vujx538o 452 6 sequence sequence NN cord-274141-vujx538o 452 7 of of IN cord-274141-vujx538o 452 8 SARS SARS NNP cord-274141-vujx538o 452 9 - - HYPH cord-274141-vujx538o 452 10 CoV CoV NNP cord-274141-vujx538o 452 11 is be VBZ cord-274141-vujx538o 452 12 very very RB cord-274141-vujx538o 452 13 similar similar JJ cord-274141-vujx538o 452 14 to to IN cord-274141-vujx538o 452 15 that that DT cord-274141-vujx538o 452 16 of of IN cord-274141-vujx538o 452 17 SARS SARS NNP cord-274141-vujx538o 452 18 - - HYPH cord-274141-vujx538o 452 19 CoV-2 CoV-2 NNP cord-274141-vujx538o 453 1 ( ( -LRB- cord-274141-vujx538o 453 2 Tahir Tahir NNP cord-274141-vujx538o 453 3 ul ul NN cord-274141-vujx538o 453 4 Qamar Qamar NNP cord-274141-vujx538o 453 5 et et NNP cord-274141-vujx538o 453 6 al al NNP cord-274141-vujx538o 453 7 . . NNP cord-274141-vujx538o 453 8 2020 2020 CD cord-274141-vujx538o 453 9 ) ) -RRB- cord-274141-vujx538o 453 10 . . . cord-274141-vujx538o 454 1 Phylogenetic phylogenetic JJ cord-274141-vujx538o 454 2 analysis analysis NN cord-274141-vujx538o 454 3 of of IN cord-274141-vujx538o 454 4 whole whole JJ cord-274141-vujx538o 454 5 genomes genome NNS cord-274141-vujx538o 454 6 reveals reveal VBZ cord-274141-vujx538o 454 7 that that IN cord-274141-vujx538o 454 8 SARS SARS NNP cord-274141-vujx538o 454 9 - - HYPH cord-274141-vujx538o 454 10 CoV-2 CoV-2 NNP cord-274141-vujx538o 454 11 shares share NNS cord-274141-vujx538o 454 12 79.7 79.7 CD cord-274141-vujx538o 454 13 % % NN cord-274141-vujx538o 454 14 nucleotide nucleotide JJ cord-274141-vujx538o 454 15 sequence sequence NN cord-274141-vujx538o 454 16 identity identity NN cord-274141-vujx538o 454 17 with with IN cord-274141-vujx538o 454 18 SARS SARS NNP cord-274141-vujx538o 454 19 - - HYPH cord-274141-vujx538o 454 20 CoV CoV NNP cord-274141-vujx538o 454 21 Zhou Zhou NNP cord-274141-vujx538o 454 22 et et NNP cord-274141-vujx538o 454 23 al al NNP cord-274141-vujx538o 454 24 . . NNP cord-274141-vujx538o 454 25 , , , cord-274141-vujx538o 454 26 2020a 2020a CD cord-274141-vujx538o 454 27 , , , cord-274141-vujx538o 454 28 b b LS cord-274141-vujx538o 454 29 ) ) -RRB- cord-274141-vujx538o 454 30 . . . cord-274141-vujx538o 455 1 Compared compare VBN cord-274141-vujx538o 455 2 with with IN cord-274141-vujx538o 455 3 SARS SARS NNP cord-274141-vujx538o 455 4 - - HYPH cord-274141-vujx538o 455 5 CoV CoV NNP cord-274141-vujx538o 455 6 , , , cord-274141-vujx538o 455 7 the the DT cord-274141-vujx538o 455 8 envelope envelope NN cord-274141-vujx538o 455 9 and and CC cord-274141-vujx538o 455 10 nucleocapsid nucleocapsid NN cord-274141-vujx538o 455 11 proteins protein NNS cord-274141-vujx538o 455 12 of of IN cord-274141-vujx538o 455 13 SARS SARS NNP cord-274141-vujx538o 455 14 - - HYPH cord-274141-vujx538o 455 15 CoV-2 CoV-2 NNP cord-274141-vujx538o 455 16 share share NN cord-274141-vujx538o 455 17 sequence sequence NN cord-274141-vujx538o 455 18 identities identity NNS cord-274141-vujx538o 455 19 of of IN cord-274141-vujx538o 455 20 96 96 CD cord-274141-vujx538o 455 21 % % NN cord-274141-vujx538o 455 22 and and CC cord-274141-vujx538o 455 23 89.6 89.6 CD cord-274141-vujx538o 455 24 % % NN cord-274141-vujx538o 455 25 , , , cord-274141-vujx538o 455 26 respectively respectively RB cord-274141-vujx538o 455 27 ( ( -LRB- cord-274141-vujx538o 455 28 Zhou Zhou NNP cord-274141-vujx538o 455 29 et et NNP cord-274141-vujx538o 455 30 al al NNP cord-274141-vujx538o 455 31 . . NNP cord-274141-vujx538o 455 32 , , , cord-274141-vujx538o 455 33 2020a 2020a CD cord-274141-vujx538o 455 34 , , , cord-274141-vujx538o 455 35 b b LS cord-274141-vujx538o 455 36 ) ) -RRB- cord-274141-vujx538o 455 37 . . . cord-274141-vujx538o 456 1 The the DT cord-274141-vujx538o 456 2 virion virion NN cord-274141-vujx538o 456 3 of of IN cord-274141-vujx538o 456 4 SARS SARS NNP cord-274141-vujx538o 456 5 - - HYPH cord-274141-vujx538o 456 6 CoV-2 CoV-2 NNP cord-274141-vujx538o 456 7 consists consist VBZ cord-274141-vujx538o 456 8 of of IN cord-274141-vujx538o 456 9 a a DT cord-274141-vujx538o 456 10 similar similar JJ cord-274141-vujx538o 456 11 structure structure NN cord-274141-vujx538o 456 12 as as IN cord-274141-vujx538o 456 13 SARS SARS NNP cord-274141-vujx538o 456 14 - - HYPH cord-274141-vujx538o 456 15 CoV CoV NNP cord-274141-vujx538o 456 16 and and CC cord-274141-vujx538o 456 17 MERS MERS NNP cord-274141-vujx538o 457 1 -CoV. -cov. ADD cord-274141-vujx538o 458 1 Like like IN cord-274141-vujx538o 458 2 SARS SARS NNP cord-274141-vujx538o 458 3 - - HYPH cord-274141-vujx538o 458 4 CoV CoV NNP cord-274141-vujx538o 458 5 , , , cord-274141-vujx538o 458 6 SARS SARS NNP cord-274141-vujx538o 458 7 - - HYPH cord-274141-vujx538o 458 8 CoV-2 CoV-2 NNP cord-274141-vujx538o 458 9 also also RB cord-274141-vujx538o 458 10 uses use VBZ cord-274141-vujx538o 458 11 ACE2 ACE2 NNP cord-274141-vujx538o 458 12 as as IN cord-274141-vujx538o 458 13 its -PRON- PRP$ cord-274141-vujx538o 458 14 cellular cellular JJ cord-274141-vujx538o 458 15 receptor receptor NN cord-274141-vujx538o 458 16 to to TO cord-274141-vujx538o 458 17 enter enter VB cord-274141-vujx538o 458 18 host host NN cord-274141-vujx538o 458 19 cells cell NNS cord-274141-vujx538o 458 20 ( ( -LRB- cord-274141-vujx538o 458 21 Zhou Zhou NNP cord-274141-vujx538o 458 22 et et NNP cord-274141-vujx538o 458 23 al al NNP cord-274141-vujx538o 458 24 . . NNP cord-274141-vujx538o 458 25 , , , cord-274141-vujx538o 458 26 2020a 2020a CD cord-274141-vujx538o 458 27 , , , cord-274141-vujx538o 458 28 b b LS cord-274141-vujx538o 458 29 ) ) -RRB- cord-274141-vujx538o 458 30 . . . cord-274141-vujx538o 459 1 The the DT cord-274141-vujx538o 459 2 chymotrypsin chymotrypsin NN cord-274141-vujx538o 459 3 - - HYPH cord-274141-vujx538o 459 4 like like JJ cord-274141-vujx538o 459 5 protease protease NN cord-274141-vujx538o 459 6 ( ( -LRB- cord-274141-vujx538o 459 7 3CL 3CL NNP cord-274141-vujx538o 459 8 pro pro JJ cord-274141-vujx538o 459 9 ) ) -RRB- cord-274141-vujx538o 459 10 of of IN cord-274141-vujx538o 459 11 SARS SARS NNP cord-274141-vujx538o 459 12 - - HYPH cord-274141-vujx538o 459 13 CoV CoV NNP cord-274141-vujx538o 459 14 is be VBZ cord-274141-vujx538o 459 15 conserved conserve VBN cord-274141-vujx538o 459 16 and and CC cord-274141-vujx538o 459 17 shares share NNS cord-274141-vujx538o 459 18 99.02 99.02 CD cord-274141-vujx538o 459 19 % % NN cord-274141-vujx538o 459 20 sequence sequence NN cord-274141-vujx538o 459 21 identity identity NN cord-274141-vujx538o 459 22 with with IN cord-274141-vujx538o 459 23 SARS SARS NNP cord-274141-vujx538o 459 24 - - HYPH cord-274141-vujx538o 459 25 CoV-2 CoV-2 NNP cord-274141-vujx538o 459 26 3CL 3cl CD cord-274141-vujx538o 459 27 pro pro JJ cord-274141-vujx538o 459 28 ( ( -LRB- cord-274141-vujx538o 459 29 Tahir Tahir NNP cord-274141-vujx538o 459 30 ul ul NN cord-274141-vujx538o 459 31 Qamar Qamar NNP cord-274141-vujx538o 459 32 et et NNP cord-274141-vujx538o 459 33 al al NNP cord-274141-vujx538o 459 34 . . NNP cord-274141-vujx538o 459 35 2020 2020 CD cord-274141-vujx538o 459 36 ) ) -RRB- cord-274141-vujx538o 459 37 . . . cord-274141-vujx538o 460 1 These these DT cord-274141-vujx538o 460 2 comparative comparative JJ cord-274141-vujx538o 460 3 genomic genomic JJ cord-274141-vujx538o 460 4 similarities similarity NNS cord-274141-vujx538o 460 5 signify signify VBP cord-274141-vujx538o 460 6 one one CD cord-274141-vujx538o 460 7 epic epic JJ cord-274141-vujx538o 460 8 biomedical biomedical JJ cord-274141-vujx538o 460 9 prospect prospect NN cord-274141-vujx538o 460 10 : : : cord-274141-vujx538o 460 11 if if IN cord-274141-vujx538o 460 12 medicinal medicinal JJ cord-274141-vujx538o 460 13 plants plant NNS cord-274141-vujx538o 460 14 used use VBN cord-274141-vujx538o 460 15 against against IN cord-274141-vujx538o 460 16 SARS SARS NNP cord-274141-vujx538o 460 17 - - HYPH cord-274141-vujx538o 460 18 CoV CoV NNP cord-274141-vujx538o 460 19 and and CC cord-274141-vujx538o 460 20 MERS MERS NNP cord-274141-vujx538o 460 21 - - HYPH cord-274141-vujx538o 460 22 CoV CoV NNP cord-274141-vujx538o 460 23 are be VBP cord-274141-vujx538o 460 24 carefully carefully RB cord-274141-vujx538o 460 25 repurposed repurpose VBN cord-274141-vujx538o 460 26 , , , cord-274141-vujx538o 460 27 they -PRON- PRP cord-274141-vujx538o 460 28 could could MD cord-274141-vujx538o 460 29 be be VB cord-274141-vujx538o 460 30 effective effective JJ cord-274141-vujx538o 460 31 against against IN cord-274141-vujx538o 460 32 SARS SARS NNP cord-274141-vujx538o 460 33 - - HYPH cord-274141-vujx538o 460 34 CoV-2 CoV-2 NNP cord-274141-vujx538o 460 35 . . . cord-274141-vujx538o 461 1 In in IN cord-274141-vujx538o 461 2 this this DT cord-274141-vujx538o 461 3 new new JJ cord-274141-vujx538o 461 4 normality normality NN cord-274141-vujx538o 461 5 , , , cord-274141-vujx538o 461 6 natural natural JJ cord-274141-vujx538o 461 7 products product NNS cord-274141-vujx538o 461 8 should should MD cord-274141-vujx538o 461 9 become become VB cord-274141-vujx538o 461 10 part part NN cord-274141-vujx538o 461 11 of of IN cord-274141-vujx538o 461 12 the the DT cord-274141-vujx538o 461 13 COVID-19 COVID-19 NNP cord-274141-vujx538o 461 14 survival survival NN cord-274141-vujx538o 461 15 kit kit NN cord-274141-vujx538o 461 16 . . . cord-274141-vujx538o 462 1 In in IN cord-274141-vujx538o 462 2 the the DT cord-274141-vujx538o 462 3 absence absence NN cord-274141-vujx538o 462 4 of of IN cord-274141-vujx538o 462 5 an an DT cord-274141-vujx538o 462 6 effective effective JJ cord-274141-vujx538o 462 7 and and CC cord-274141-vujx538o 462 8 safe safe JJ cord-274141-vujx538o 462 9 drug drug NN cord-274141-vujx538o 462 10 that that WDT cord-274141-vujx538o 462 11 inhibits inhibit VBZ cord-274141-vujx538o 462 12 SARS SARS NNP cord-274141-vujx538o 462 13 - - HYPH cord-274141-vujx538o 462 14 CoV-2 CoV-2 NNP cord-274141-vujx538o 462 15 , , , cord-274141-vujx538o 462 16 the the DT cord-274141-vujx538o 462 17 use use NN cord-274141-vujx538o 462 18 of of IN cord-274141-vujx538o 462 19 antimalarial antimalarial JJ cord-274141-vujx538o 462 20 plants plant NNS cord-274141-vujx538o 462 21 and and CC cord-274141-vujx538o 462 22 synthetic synthetic JJ cord-274141-vujx538o 462 23 drugs drug NNS cord-274141-vujx538o 462 24 has have VBZ cord-274141-vujx538o 462 25 gained gain VBN cord-274141-vujx538o 462 26 traction traction NN cord-274141-vujx538o 462 27 in in IN cord-274141-vujx538o 462 28 the the DT cord-274141-vujx538o 462 29 treatment treatment NN cord-274141-vujx538o 462 30 of of IN cord-274141-vujx538o 462 31 COVID-19 COVID-19 NNP cord-274141-vujx538o 462 32 . . . cord-274141-vujx538o 463 1 The the DT cord-274141-vujx538o 463 2 notion notion NN cord-274141-vujx538o 463 3 that that IN cord-274141-vujx538o 463 4 antimalarial antimalarial JJ cord-274141-vujx538o 463 5 plants plant NNS cord-274141-vujx538o 463 6 in in IN cord-274141-vujx538o 463 7 the the DT cord-274141-vujx538o 463 8 genus genus NN cord-274141-vujx538o 463 9 Artemisia Artemisia NNP cord-274141-vujx538o 463 10 L. L. NNP cord-274141-vujx538o 463 11 can can MD cord-274141-vujx538o 463 12 be be VB cord-274141-vujx538o 463 13 repurposed repurpose VBN cord-274141-vujx538o 463 14 to to TO cord-274141-vujx538o 463 15 prevent prevent VB cord-274141-vujx538o 463 16 and and CC cord-274141-vujx538o 463 17 treat treat VB cord-274141-vujx538o 463 18 COVID-19 COVID-19 NNP cord-274141-vujx538o 463 19 has have VBZ cord-274141-vujx538o 463 20 often often RB cord-274141-vujx538o 463 21 been be VBN cord-274141-vujx538o 463 22 associated associate VBN cord-274141-vujx538o 463 23 with with IN cord-274141-vujx538o 463 24 experimental experimental JJ cord-274141-vujx538o 463 25 data datum NNS cord-274141-vujx538o 463 26 that that IN cord-274141-vujx538o 463 27 chloroquine chloroquine NN cord-274141-vujx538o 463 28 inhibits inhibit VBZ cord-274141-vujx538o 463 29 the the DT cord-274141-vujx538o 463 30 replication replication NN cord-274141-vujx538o 463 31 of of IN cord-274141-vujx538o 463 32 viruses virus NNS cord-274141-vujx538o 463 33 . . . cord-274141-vujx538o 464 1 Chloroquine Chloroquine NNP cord-274141-vujx538o 464 2 inhibits inhibit VBZ cord-274141-vujx538o 464 3 chikungunya chikungunya NN cord-274141-vujx538o 464 4 virus virus NN cord-274141-vujx538o 464 5 replication replication NN cord-274141-vujx538o 464 6 in in IN cord-274141-vujx538o 464 7 Vero Vero NNP cord-274141-vujx538o 464 8 A A NNP cord-274141-vujx538o 464 9 cells cell NNS cord-274141-vujx538o 464 10 ( ( -LRB- cord-274141-vujx538o 464 11 IC IC NNP cord-274141-vujx538o 464 12 50 50 CD cord-274141-vujx538o 464 13 7 7 CD cord-274141-vujx538o 465 1 μM μM NNP cord-274141-vujx538o 465 2 , , , cord-274141-vujx538o 465 3 IC IC NNP cord-274141-vujx538o 465 4 90 90 CD cord-274141-vujx538o 465 5 15 15 CD cord-274141-vujx538o 466 1 μM μM NNP cord-274141-vujx538o 466 2 , , , cord-274141-vujx538o 466 3 selectivity selectivity NN cord-274141-vujx538o 466 4 index index NN cord-274141-vujx538o 466 5 = = SYM cord-274141-vujx538o 466 6 37.14 37.14 CD cord-274141-vujx538o 466 7 ) ) -RRB- cord-274141-vujx538o 466 8 in in IN cord-274141-vujx538o 466 9 a a DT cord-274141-vujx538o 466 10 dose dose NN cord-274141-vujx538o 466 11 - - HYPH cord-274141-vujx538o 466 12 dependent dependent JJ cord-274141-vujx538o 466 13 manner manner NN cord-274141-vujx538o 466 14 . . . cord-274141-vujx538o 467 1 Chloroquine Chloroquine NNP cord-274141-vujx538o 467 2 , , , cord-274141-vujx538o 467 3 whose whose WP$ cord-274141-vujx538o 467 4 chemical chemical NN cord-274141-vujx538o 467 5 structure structure NN cord-274141-vujx538o 467 6 mimics mimic VBZ cord-274141-vujx538o 467 7 nucleoside nucleoside JJ cord-274141-vujx538o 467 8 analogues analogue NNS cord-274141-vujx538o 467 9 , , , cord-274141-vujx538o 467 10 has have VBZ cord-274141-vujx538o 467 11 in in IN cord-274141-vujx538o 467 12 vitro vitro FW cord-274141-vujx538o 467 13 activity activity NN cord-274141-vujx538o 467 14 against against IN cord-274141-vujx538o 467 15 SARS SARS NNP cord-274141-vujx538o 467 16 - - HYPH cord-274141-vujx538o 467 17 CoV CoV NNP cord-274141-vujx538o 467 18 and and CC cord-274141-vujx538o 467 19 SARS SARS NNP cord-274141-vujx538o 467 20 - - HYPH cord-274141-vujx538o 467 21 CoV-2 CoV-2 NNP cord-274141-vujx538o 467 22 ) ) -RRB- cord-274141-vujx538o 467 23 . . . cord-274141-vujx538o 468 1 An an DT cord-274141-vujx538o 468 2 antimalarial antimalarial JJ cord-274141-vujx538o 468 3 drug drug NN cord-274141-vujx538o 468 4 known know VBN cord-274141-vujx538o 468 5 since since IN cord-274141-vujx538o 468 6 1934 1934 CD cord-274141-vujx538o 468 7 , , , cord-274141-vujx538o 468 8 chloroquine chloroquine NN cord-274141-vujx538o 468 9 blocks block VBZ cord-274141-vujx538o 468 10 HIV-1 HIV-1 NNP cord-274141-vujx538o 468 11 and and CC cord-274141-vujx538o 468 12 HCoVs HCoVs NNP cord-274141-vujx538o 468 13 at at IN cord-274141-vujx538o 468 14 a a DT cord-274141-vujx538o 468 15 very very RB cord-274141-vujx538o 468 16 early early JJ cord-274141-vujx538o 468 17 stage stage NN cord-274141-vujx538o 468 18 ; ; : cord-274141-vujx538o 468 19 it -PRON- PRP cord-274141-vujx538o 468 20 also also RB cord-274141-vujx538o 468 21 inhibits inhibit VBZ cord-274141-vujx538o 468 22 the the DT cord-274141-vujx538o 468 23 replication replication NN cord-274141-vujx538o 468 24 of of IN cord-274141-vujx538o 468 25 MERS MERS NNP cord-274141-vujx538o 468 26 - - HYPH cord-274141-vujx538o 468 27 CoV CoV NNP cord-274141-vujx538o 468 28 in in IN cord-274141-vujx538o 468 29 a a DT cord-274141-vujx538o 468 30 dose dose NN cord-274141-vujx538o 468 31 - - HYPH cord-274141-vujx538o 468 32 dependent dependent JJ cord-274141-vujx538o 468 33 mode mode NN cord-274141-vujx538o 468 34 ( ( -LRB- cord-274141-vujx538o 468 35 EC EC NNP cord-274141-vujx538o 468 36 50 50 CD cord-274141-vujx538o 468 37 of of IN cord-274141-vujx538o 468 38 3 3 CD cord-274141-vujx538o 468 39 μM μm CD cord-274141-vujx538o 468 40 ) ) -RRB- cord-274141-vujx538o 469 1 ( ( -LRB- cord-274141-vujx538o 469 2 de de FW cord-274141-vujx538o 469 3 Wilde Wilde NNP cord-274141-vujx538o 469 4 et et NNP cord-274141-vujx538o 469 5 al al NNP cord-274141-vujx538o 469 6 . . NNP cord-274141-vujx538o 469 7 2014 2014 CD cord-274141-vujx538o 469 8 ) ) -RRB- cord-274141-vujx538o 469 9 . . . cord-274141-vujx538o 470 1 Chloroquine Chloroquine NNP cord-274141-vujx538o 470 2 exerts exert VBZ cord-274141-vujx538o 470 3 antiviral antiviral JJ cord-274141-vujx538o 470 4 as as RB cord-274141-vujx538o 470 5 well well RB cord-274141-vujx538o 470 6 as as IN cord-274141-vujx538o 470 7 immunomodulatory immunomodulatory JJ cord-274141-vujx538o 470 8 properties property NNS cord-274141-vujx538o 470 9 . . . cord-274141-vujx538o 471 1 Chloroquine Chloroquine NNP cord-274141-vujx538o 471 2 ( ( -LRB- cord-274141-vujx538o 471 3 EC EC NNP cord-274141-vujx538o 471 4 50 50 CD cord-274141-vujx538o 471 5 of of IN cord-274141-vujx538o 472 1 1.13 1.13 CD cord-274141-vujx538o 472 2 μM μm NN cord-274141-vujx538o 472 3 against against IN cord-274141-vujx538o 472 4 SARS SARS NNP cord-274141-vujx538o 472 5 - - HYPH cord-274141-vujx538o 472 6 CoV-2 CoV-2 NNP cord-274141-vujx538o 473 1 ) ) -RRB- cord-274141-vujx538o 473 2 blocks block VBZ cord-274141-vujx538o 473 3 viral viral JJ cord-274141-vujx538o 473 4 infection infection NN cord-274141-vujx538o 473 5 by by IN cord-274141-vujx538o 473 6 increasing increase VBG cord-274141-vujx538o 473 7 the the DT cord-274141-vujx538o 473 8 endosomal endosomal NNP cord-274141-vujx538o 474 1 pH pH NNP cord-274141-vujx538o 474 2 required require VBN cord-274141-vujx538o 474 3 for for IN cord-274141-vujx538o 474 4 viral viral JJ cord-274141-vujx538o 474 5 fusion fusion NN cord-274141-vujx538o 475 1 ( ( -LRB- cord-274141-vujx538o 475 2 Vellingiri Vellingiri NNP cord-274141-vujx538o 475 3 et et NNP cord-274141-vujx538o 475 4 al al NNP cord-274141-vujx538o 475 5 . . NNP cord-274141-vujx538o 475 6 2020 2020 CD cord-274141-vujx538o 475 7 ) ) -RRB- cord-274141-vujx538o 475 8 . . . cord-274141-vujx538o 476 1 A a DT cord-274141-vujx538o 476 2 9-aminoquinoline 9-aminoquinoline CD cord-274141-vujx538o 476 3 , , , cord-274141-vujx538o 476 4 chloroquine chloroquine NN cord-274141-vujx538o 476 5 inhibits inhibit VBZ cord-274141-vujx538o 476 6 SARS SARS NNP cord-274141-vujx538o 476 7 - - HYPH cord-274141-vujx538o 476 8 CoV cov NN cord-274141-vujx538o 476 9 replication replication NN cord-274141-vujx538o 476 10 and and CC cord-274141-vujx538o 476 11 downregulates downregulate VBZ cord-274141-vujx538o 476 12 IFN IFN NNP cord-274141-vujx538o 476 13 - - HYPH cord-274141-vujx538o 476 14 γ γ NNP cord-274141-vujx538o 476 15 and and CC cord-274141-vujx538o 476 16 TNF TNF NNP cord-274141-vujx538o 476 17 - - HYPH cord-274141-vujx538o 476 18 α α NN cord-274141-vujx538o 476 19 production production NN cord-274141-vujx538o 476 20 in in IN cord-274141-vujx538o 476 21 mice mouse NNS cord-274141-vujx538o 477 1 ( ( -LRB- cord-274141-vujx538o 477 2 Prinsloo Prinsloo NNP cord-274141-vujx538o 477 3 et et NNP cord-274141-vujx538o 477 4 al al NNP cord-274141-vujx538o 477 5 . . . cord-274141-vujx538o 477 6 2018 2018 CD cord-274141-vujx538o 477 7 ) ) -RRB- cord-274141-vujx538o 477 8 . . . cord-274141-vujx538o 478 1 In in IN cord-274141-vujx538o 478 2 the the DT cord-274141-vujx538o 478 3 first first JJ cord-274141-vujx538o 478 4 half half NN cord-274141-vujx538o 478 5 of of IN cord-274141-vujx538o 478 6 2020 2020 CD cord-274141-vujx538o 478 7 , , , cord-274141-vujx538o 478 8 clinical clinical JJ cord-274141-vujx538o 478 9 t t NN cord-274141-vujx538o 478 10 r r NN cord-274141-vujx538o 478 11 i i PRP cord-274141-vujx538o 478 12 a a DT cord-274141-vujx538o 478 13 l l NN cord-274141-vujx538o 478 14 s s NN cord-274141-vujx538o 478 15 ( ( -LRB- cord-274141-vujx538o 478 16 N N NNP cord-274141-vujx538o 478 17 C c NN cord-274141-vujx538o 478 18 T t NN cord-274141-vujx538o 478 19 0 0 CD cord-274141-vujx538o 478 20 4 4 CD cord-274141-vujx538o 478 21 2 2 CD cord-274141-vujx538o 478 22 6 6 CD cord-274141-vujx538o 478 23 1 1 CD cord-274141-vujx538o 478 24 5 5 CD cord-274141-vujx538o 478 25 1 1 CD cord-274141-vujx538o 478 26 7 7 CD cord-274141-vujx538o 478 27 a a DT cord-274141-vujx538o 478 28 n n NN cord-274141-vujx538o 478 29 d d NN cord-274141-vujx538o 478 30 N n NN cord-274141-vujx538o 478 31 C c NN cord-274141-vujx538o 478 32 T t NN cord-274141-vujx538o 478 33 0 0 CD cord-274141-vujx538o 478 34 4 4 CD cord-274141-vujx538o 478 35 3 3 CD cord-274141-vujx538o 478 36 0 0 CD cord-274141-vujx538o 478 37 7 7 CD cord-274141-vujx538o 478 38 6 6 CD cord-274141-vujx538o 478 39 9 9 CD cord-274141-vujx538o 478 40 3 3 CD cord-274141-vujx538o 478 41 ) ) -RRB- cord-274141-vujx538o 478 42 o o NN cord-274141-vujx538o 478 43 f f NNP cord-274141-vujx538o 478 44 hydroxychloroquine hydroxychloroquine NN cord-274141-vujx538o 478 45 treatment treatment NN cord-274141-vujx538o 478 46 for for IN cord-274141-vujx538o 478 47 COVID-19 COVID-19 NNP cord-274141-vujx538o 478 48 were be VBD cord-274141-vujx538o 478 49 underway underway JJ cord-274141-vujx538o 478 50 in in IN cord-274141-vujx538o 478 51 China China NNP cord-274141-vujx538o 479 1 ( ( -LRB- cord-274141-vujx538o 479 2 Wang Wang NNP cord-274141-vujx538o 479 3 et et NNP cord-274141-vujx538o 479 4 al al NNP cord-274141-vujx538o 479 5 . . NNP cord-274141-vujx538o 479 6 2020b 2020b CD cord-274141-vujx538o 479 7 ) ) -RRB- cord-274141-vujx538o 479 8 . . . cord-274141-vujx538o 480 1 The the DT cord-274141-vujx538o 480 2 World World NNP cord-274141-vujx538o 480 3 Health Health NNP cord-274141-vujx538o 480 4 Organization Organization NNP cord-274141-vujx538o 480 5 announced announce VBD cord-274141-vujx538o 480 6 it -PRON- PRP cord-274141-vujx538o 480 7 would would MD cord-274141-vujx538o 480 8 resume resume VB cord-274141-vujx538o 480 9 its -PRON- PRP$ cord-274141-vujx538o 480 10 halted halt VBN cord-274141-vujx538o 480 11 randomized randomize VBN cord-274141-vujx538o 480 12 controlled control VBN cord-274141-vujx538o 480 13 trials trial NNS cord-274141-vujx538o 480 14 to to TO cord-274141-vujx538o 480 15 find find VB cord-274141-vujx538o 480 16 out out RP cord-274141-vujx538o 480 17 whether whether IN cord-274141-vujx538o 480 18 hydroxychloroquine hydroxychloroquine NNP cord-274141-vujx538o 480 19 was be VBD cord-274141-vujx538o 480 20 able able JJ cord-274141-vujx538o 480 21 to to TO cord-274141-vujx538o 480 22 prevent prevent VB cord-274141-vujx538o 480 23 COVID-19 COVID-19 NNP cord-274141-vujx538o 480 24 . . . cord-274141-vujx538o 481 1 This this DT cord-274141-vujx538o 481 2 was be VBD cord-274141-vujx538o 481 3 after after IN cord-274141-vujx538o 481 4 the the DT cord-274141-vujx538o 481 5 Lancet Lancet NNP cord-274141-vujx538o 481 6 on on IN cord-274141-vujx538o 481 7 4 4 CD cord-274141-vujx538o 481 8 June June NNP cord-274141-vujx538o 481 9 2020 2020 CD cord-274141-vujx538o 481 10 , , , cord-274141-vujx538o 481 11 due due IN cord-274141-vujx538o 481 12 to to IN cord-274141-vujx538o 481 13 concerns concern NNS cord-274141-vujx538o 481 14 with with IN cord-274141-vujx538o 481 15 respect respect NN cord-274141-vujx538o 481 16 to to IN cord-274141-vujx538o 481 17 the the DT cord-274141-vujx538o 481 18 veracity veracity NN cord-274141-vujx538o 481 19 of of IN cord-274141-vujx538o 481 20 the the DT cord-274141-vujx538o 481 21 data datum NNS cord-274141-vujx538o 481 22 and and CC cord-274141-vujx538o 481 23 analyses analysis NNS cord-274141-vujx538o 481 24 , , , cord-274141-vujx538o 481 25 retracted retract VBD cord-274141-vujx538o 481 26 an an DT cord-274141-vujx538o 481 27 influential influential JJ cord-274141-vujx538o 481 28 article article NN cord-274141-vujx538o 481 29 which which WDT cord-274141-vujx538o 481 30 had have VBD cord-274141-vujx538o 481 31 earlier early RBR cord-274141-vujx538o 481 32 reported report VBN cord-274141-vujx538o 481 33 that that IN cord-274141-vujx538o 481 34 hydroxychloroquine hydroxychloroquine NN cord-274141-vujx538o 481 35 increased increase VBD cord-274141-vujx538o 481 36 the the DT cord-274141-vujx538o 481 37 mortality mortality NN cord-274141-vujx538o 481 38 of of IN cord-274141-vujx538o 481 39 COVID-19 covid-19 JJ cord-274141-vujx538o 481 40 patients patient NNS cord-274141-vujx538o 481 41 . . . cord-274141-vujx538o 482 1 On on IN cord-274141-vujx538o 482 2 15 15 CD cord-274141-vujx538o 482 3 June June NNP cord-274141-vujx538o 482 4 2020 2020 CD cord-274141-vujx538o 482 5 , , , cord-274141-vujx538o 482 6 the the DT cord-274141-vujx538o 482 7 US US NNP cord-274141-vujx538o 482 8 Food Food NNP cord-274141-vujx538o 482 9 and and CC cord-274141-vujx538o 482 10 Drug Drug NNP cord-274141-vujx538o 482 11 Administration Administration NNP cord-274141-vujx538o 482 12 revoked revoke VBD cord-274141-vujx538o 482 13 the the DT cord-274141-vujx538o 482 14 emergence emergence NN cord-274141-vujx538o 482 15 use use NN cord-274141-vujx538o 482 16 of of IN cord-274141-vujx538o 482 17 hydroxychloroquine hydroxychloroquine NN cord-274141-vujx538o 482 18 to to TO cord-274141-vujx538o 482 19 treat treat VB cord-274141-vujx538o 482 20 COVID-19 covid-19 JJ cord-274141-vujx538o 482 21 patients patient NNS cord-274141-vujx538o 482 22 after after IN cord-274141-vujx538o 482 23 reports report NNS cord-274141-vujx538o 482 24 that that IN cord-274141-vujx538o 482 25 the the DT cord-274141-vujx538o 482 26 drug drug NN cord-274141-vujx538o 482 27 increases increase VBZ cord-274141-vujx538o 482 28 the the DT cord-274141-vujx538o 482 29 risk risk NN cord-274141-vujx538o 482 30 of of IN cord-274141-vujx538o 482 31 cardiovascular cardiovascular JJ cord-274141-vujx538o 482 32 side side NN cord-274141-vujx538o 482 33 effects effect NNS cord-274141-vujx538o 482 34 including include VBG cord-274141-vujx538o 482 35 cardiomyopathy cardiomyopathy NN cord-274141-vujx538o 482 36 and and CC cord-274141-vujx538o 482 37 cardiac cardiac JJ cord-274141-vujx538o 482 38 arrest arrest NN cord-274141-vujx538o 482 39 . . . cord-274141-vujx538o 483 1 Taken take VBN cord-274141-vujx538o 483 2 together together RB cord-274141-vujx538o 483 3 , , , cord-274141-vujx538o 483 4 these these DT cord-274141-vujx538o 483 5 developments development NNS cord-274141-vujx538o 483 6 signify signify VBP cord-274141-vujx538o 483 7 that that IN cord-274141-vujx538o 483 8 many many JJ cord-274141-vujx538o 483 9 countries country NNS cord-274141-vujx538o 483 10 should should MD cord-274141-vujx538o 483 11 carefully carefully RB cord-274141-vujx538o 483 12 evaluate evaluate VB cord-274141-vujx538o 483 13 the the DT cord-274141-vujx538o 483 14 efficacy efficacy NN cord-274141-vujx538o 483 15 and and CC cord-274141-vujx538o 483 16 safety safety NN cord-274141-vujx538o 483 17 of of IN cord-274141-vujx538o 483 18 natural natural JJ cord-274141-vujx538o 483 19 antimalarial antimalarial JJ cord-274141-vujx538o 483 20 agents agent NNS cord-274141-vujx538o 483 21 for for IN cord-274141-vujx538o 483 22 the the DT cord-274141-vujx538o 483 23 possible possible JJ cord-274141-vujx538o 483 24 treatment treatment NN cord-274141-vujx538o 483 25 of of IN cord-274141-vujx538o 483 26 COVID-19 COVID-19 NNP cord-274141-vujx538o 483 27 . . . cord-274141-vujx538o 484 1 Rich rich JJ cord-274141-vujx538o 484 2 in in IN cord-274141-vujx538o 484 3 flavonoids flavonoid NNS cord-274141-vujx538o 484 4 such such JJ cord-274141-vujx538o 484 5 as as IN cord-274141-vujx538o 484 6 acacetin acacetin NNP cord-274141-vujx538o 484 7 , , , cord-274141-vujx538o 484 8 genkwanin genkwanin NNP cord-274141-vujx538o 484 9 , , , cord-274141-vujx538o 484 10 and and CC cord-274141-vujx538o 484 11 7-methoxyacacetin 7-methoxyacacetin CD cord-274141-vujx538o 484 12 , , , cord-274141-vujx538o 484 13 leaf leaf NN cord-274141-vujx538o 484 14 extracts extract NNS cord-274141-vujx538o 484 15 of of IN cord-274141-vujx538o 484 16 Artemisia Artemisia NNP cord-274141-vujx538o 484 17 afra afra NNP cord-274141-vujx538o 484 18 Jacq Jacq NNP cord-274141-vujx538o 484 19 . . . cord-274141-vujx538o 485 1 , , , cord-274141-vujx538o 485 2 a a DT cord-274141-vujx538o 485 3 common common JJ cord-274141-vujx538o 485 4 antimalarial antimalarial JJ cord-274141-vujx538o 485 5 remedy remedy NN cord-274141-vujx538o 485 6 in in IN cord-274141-vujx538o 485 7 Kenya Kenya NNP cord-274141-vujx538o 485 8 , , , cord-274141-vujx538o 485 9 Rwanda Rwanda NNP cord-274141-vujx538o 485 10 , , , cord-274141-vujx538o 485 11 and and CC cord-274141-vujx538o 485 12 Zambia Zambia NNP cord-274141-vujx538o 485 13 ( ( -LRB- cord-274141-vujx538o 485 14 Chinsembu Chinsembu NNP cord-274141-vujx538o 485 15 2015 2015 CD cord-274141-vujx538o 485 16 ) ) -RRB- cord-274141-vujx538o 485 17 , , , cord-274141-vujx538o 485 18 should should MD cord-274141-vujx538o 485 19 be be VB cord-274141-vujx538o 485 20 carefully carefully RB cord-274141-vujx538o 485 21 evaluated evaluate VBN cord-274141-vujx538o 485 22 in in IN cord-274141-vujx538o 485 23 COVID-19 COVID-19 NNP cord-274141-vujx538o 485 24 patients patient NNS cord-274141-vujx538o 485 25 . . . cord-274141-vujx538o 486 1 The the DT cord-274141-vujx538o 486 2 need need NN cord-274141-vujx538o 486 3 for for IN cord-274141-vujx538o 486 4 medicinal medicinal JJ cord-274141-vujx538o 486 5 plants plant NNS cord-274141-vujx538o 486 6 and and CC cord-274141-vujx538o 486 7 other other JJ cord-274141-vujx538o 486 8 natural natural JJ cord-274141-vujx538o 486 9 products product NNS cord-274141-vujx538o 486 10 to to TO cord-274141-vujx538o 486 11 treat treat VB cord-274141-vujx538o 486 12 COVID-19 COVID-19 NNP cord-274141-vujx538o 486 13 patients patient NNS cord-274141-vujx538o 486 14 is be VBZ cord-274141-vujx538o 486 15 urgent urgent JJ cord-274141-vujx538o 486 16 especially especially RB cord-274141-vujx538o 486 17 in in IN cord-274141-vujx538o 486 18 Africa Africa NNP cord-274141-vujx538o 486 19 where where WRB cord-274141-vujx538o 486 20 health health NN cord-274141-vujx538o 486 21 systems system NNS cord-274141-vujx538o 486 22 grapple grapple VBP cord-274141-vujx538o 486 23 with with IN cord-274141-vujx538o 486 24 high high JJ cord-274141-vujx538o 486 25 caseloads caseload NNS cord-274141-vujx538o 486 26 of of IN cord-274141-vujx538o 486 27 HIV HIV NNP cord-274141-vujx538o 486 28 / / SYM cord-274141-vujx538o 486 29 AIDS AIDS NNP cord-274141-vujx538o 486 30 and and CC cord-274141-vujx538o 486 31 malaria malaria NN cord-274141-vujx538o 486 32 in in IN cord-274141-vujx538o 486 33 addition addition NN cord-274141-vujx538o 486 34 to to IN cord-274141-vujx538o 486 35 being be VBG cord-274141-vujx538o 486 36 heavily heavily RB cord-274141-vujx538o 486 37 underresourced underresourced JJ cord-274141-vujx538o 486 38 in in IN cord-274141-vujx538o 486 39 terms term NNS cord-274141-vujx538o 486 40 of of IN cord-274141-vujx538o 486 41 funding funding NN cord-274141-vujx538o 486 42 and and CC cord-274141-vujx538o 486 43 staff staff NN cord-274141-vujx538o 486 44 . . . cord-274141-vujx538o 487 1 Overall overall RB cord-274141-vujx538o 487 2 , , , cord-274141-vujx538o 487 3 plants plant NNS cord-274141-vujx538o 487 4 with with IN cord-274141-vujx538o 487 5 antiplasmodial antiplasmodial JJ cord-274141-vujx538o 487 6 ( ( -LRB- cord-274141-vujx538o 487 7 Chinsembu Chinsembu NNP cord-274141-vujx538o 487 8 2015 2015 CD cord-274141-vujx538o 487 9 ) ) -RRB- cord-274141-vujx538o 487 10 , , , cord-274141-vujx538o 487 11 anti anti JJ cord-274141-vujx538o 487 12 - - JJ cord-274141-vujx538o 487 13 tuberculosis tuberculosis JJ cord-274141-vujx538o 487 14 ( ( -LRB- cord-274141-vujx538o 487 15 Chinsembu Chinsembu NNP cord-274141-vujx538o 487 16 2016b 2016b CD cord-274141-vujx538o 487 17 ) ) -RRB- cord-274141-vujx538o 487 18 , , , cord-274141-vujx538o 487 19 and and CC cord-274141-vujx538o 487 20 anti anti JJ cord-274141-vujx538o 487 21 - - JJ cord-274141-vujx538o 487 22 HIV hiv JJ cord-274141-vujx538o 487 23 replication replication NN cord-274141-vujx538o 487 24 ( ( -LRB- cord-274141-vujx538o 487 25 Chinsembu Chinsembu NNP cord-274141-vujx538o 487 26 2019 2019 CD cord-274141-vujx538o 487 27 ) ) -RRB- cord-274141-vujx538o 487 28 activities activity NNS cord-274141-vujx538o 487 29 may may MD cord-274141-vujx538o 487 30 present present VB cord-274141-vujx538o 487 31 good good JJ cord-274141-vujx538o 487 32 prospects prospect NNS cord-274141-vujx538o 487 33 for for IN cord-274141-vujx538o 487 34 the the DT cord-274141-vujx538o 487 35 discovery discovery NN cord-274141-vujx538o 487 36 of of IN cord-274141-vujx538o 487 37 new new JJ cord-274141-vujx538o 487 38 active active JJ cord-274141-vujx538o 487 39 compounds compound NNS cord-274141-vujx538o 487 40 with with IN cord-274141-vujx538o 487 41 anti anti JJ cord-274141-vujx538o 487 42 - - JJ cord-274141-vujx538o 487 43 SARS SARS NNP cord-274141-vujx538o 487 44 - - HYPH cord-274141-vujx538o 487 45 CoV-2 CoV-2 NNP cord-274141-vujx538o 487 46 action action NN cord-274141-vujx538o 487 47 . . . cord-274141-vujx538o 488 1 Pechuel Pechuel NNP cord-274141-vujx538o 488 2 - - HYPH cord-274141-vujx538o 488 3 loeschea loeschea NNP cord-274141-vujx538o 488 4 leubnitziae leubnitziae NNP cord-274141-vujx538o 488 5 O. O. NNP cord-274141-vujx538o 488 6 Hoffm Hoffm NNP cord-274141-vujx538o 488 7 . . . cord-274141-vujx538o 489 1 ( ( -LRB- cord-274141-vujx538o 489 2 Asteraceae Asteraceae NNP cord-274141-vujx538o 489 3 ) ) -RRB- cord-274141-vujx538o 489 4 , , , cord-274141-vujx538o 489 5 an an DT cord-274141-vujx538o 489 6 indigenous indigenous JJ cord-274141-vujx538o 489 7 plant plant NN cord-274141-vujx538o 489 8 used use VBN cord-274141-vujx538o 489 9 to to TO cord-274141-vujx538o 489 10 " " `` cord-274141-vujx538o 489 11 steam steam VB cord-274141-vujx538o 489 12 " " '' cord-274141-vujx538o 489 13 patients patient NNS cord-274141-vujx538o 489 14 suffering suffer VBG cord-274141-vujx538o 489 15 from from IN cord-274141-vujx538o 489 16 pneumonia pneumonia NN cord-274141-vujx538o 489 17 and and CC cord-274141-vujx538o 489 18 coughs cough NNS cord-274141-vujx538o 489 19 in in IN cord-274141-vujx538o 489 20 Namibia Namibia NNP cord-274141-vujx538o 489 21 Mofolo Mofolo NNP cord-274141-vujx538o 489 22 et et NNP cord-274141-vujx538o 489 23 al al NNP cord-274141-vujx538o 489 24 . . NNP cord-274141-vujx538o 489 25 2020 2020 CD cord-274141-vujx538o 489 26 ) ) -RRB- cord-274141-vujx538o 489 27 , , , cord-274141-vujx538o 489 28 should should MD cord-274141-vujx538o 489 29 also also RB cord-274141-vujx538o 489 30 be be VB cord-274141-vujx538o 489 31 evaluated evaluate VBN cord-274141-vujx538o 489 32 for for IN cord-274141-vujx538o 489 33 anti anti JJ cord-274141-vujx538o 489 34 - - JJ cord-274141-vujx538o 489 35 COVID-19 covid-19 JJ cord-274141-vujx538o 489 36 function function NN cord-274141-vujx538o 489 37 . . . cord-274141-vujx538o 490 1 High high JJ cord-274141-vujx538o 490 2 - - HYPH cord-274141-vujx538o 490 3 throughput throughput NN cord-274141-vujx538o 490 4 screening screening NN cord-274141-vujx538o 490 5 of of IN cord-274141-vujx538o 490 6 these these DT cord-274141-vujx538o 490 7 plants plant NNS cord-274141-vujx538o 490 8 should should MD cord-274141-vujx538o 490 9 be be VB cord-274141-vujx538o 490 10 conducted conduct VBN cord-274141-vujx538o 490 11 , , , cord-274141-vujx538o 490 12 and and CC cord-274141-vujx538o 490 13 computational computational JJ cord-274141-vujx538o 490 14 techniques technique NNS cord-274141-vujx538o 490 15 can can MD cord-274141-vujx538o 490 16 quicken quicken VB cord-274141-vujx538o 490 17 the the DT cord-274141-vujx538o 490 18 process process NN cord-274141-vujx538o 490 19 . . . cord-274141-vujx538o 491 1 Moreover moreover RB cord-274141-vujx538o 491 2 , , , cord-274141-vujx538o 491 3 plant plant NN cord-274141-vujx538o 491 4 active active JJ cord-274141-vujx538o 491 5 compounds compound NNS cord-274141-vujx538o 491 6 should should MD cord-274141-vujx538o 491 7 be be VB cord-274141-vujx538o 491 8 subjected subject VBN cord-274141-vujx538o 491 9 to to IN cord-274141-vujx538o 491 10 absorption absorption NN cord-274141-vujx538o 491 11 , , , cord-274141-vujx538o 491 12 distribution distribution NN cord-274141-vujx538o 491 13 , , , cord-274141-vujx538o 491 14 metabolism metabolism NN cord-274141-vujx538o 491 15 , , , cord-274141-vujx538o 491 16 and and CC cord-274141-vujx538o 491 17 excretion excretion NN cord-274141-vujx538o 491 18 ( ( -LRB- cord-274141-vujx538o 491 19 ADME ADME NNP cord-274141-vujx538o 491 20 ) ) -RRB- cord-274141-vujx538o 491 21 evaluation evaluation NN cord-274141-vujx538o 491 22 to to TO cord-274141-vujx538o 491 23 verify verify VB cord-274141-vujx538o 491 24 that that IN cord-274141-vujx538o 491 25 oral oral JJ cord-274141-vujx538o 491 26 administration administration NN cord-274141-vujx538o 491 27 would would MD cord-274141-vujx538o 491 28 be be VB cord-274141-vujx538o 491 29 effective effective JJ cord-274141-vujx538o 491 30 ) ) -RRB- cord-274141-vujx538o 491 31 . . . cord-274141-vujx538o 492 1 Analysis analysis NN cord-274141-vujx538o 492 2 of of IN cord-274141-vujx538o 492 3 structure structure NN cord-274141-vujx538o 492 4 - - HYPH cord-274141-vujx538o 492 5 activity activity NN cord-274141-vujx538o 492 6 relationships relationship NNS cord-274141-vujx538o 492 7 may may MD cord-274141-vujx538o 492 8 be be VB cord-274141-vujx538o 492 9 helpful helpful JJ cord-274141-vujx538o 492 10 in in IN cord-274141-vujx538o 492 11 understanding understand VBG cord-274141-vujx538o 492 12 the the DT cord-274141-vujx538o 492 13 mechanisms mechanism NNS cord-274141-vujx538o 492 14 of of IN cord-274141-vujx538o 492 15 certain certain JJ cord-274141-vujx538o 492 16 active active JJ cord-274141-vujx538o 492 17 compounds compound NNS cord-274141-vujx538o 492 18 such such JJ cord-274141-vujx538o 492 19 as as IN cord-274141-vujx538o 492 20 myricetin myricetin NNP cord-274141-vujx538o 492 21 ( ( -LRB- cord-274141-vujx538o 492 22 5 5 CD cord-274141-vujx538o 492 23 ) ) -RRB- cord-274141-vujx538o 492 24 , , , cord-274141-vujx538o 492 25 baicalein baicalein NNP cord-274141-vujx538o 492 26 ( ( -LRB- cord-274141-vujx538o 492 27 6 6 CD cord-274141-vujx538o 492 28 ) ) -RRB- cord-274141-vujx538o 492 29 , , , cord-274141-vujx538o 492 30 and and CC cord-274141-vujx538o 492 31 quercetin quercetin NN cord-274141-vujx538o 492 32 . . . cord-274141-vujx538o 493 1 Further further JJ cord-274141-vujx538o 493 2 studies study NNS cord-274141-vujx538o 493 3 including include VBG cord-274141-vujx538o 493 4 in in IN cord-274141-vujx538o 493 5 silico silico NN cord-274141-vujx538o 493 6 molecular molecular JJ cord-274141-vujx538o 493 7 docking docking NN cord-274141-vujx538o 493 8 simulations simulation NNS cord-274141-vujx538o 493 9 should should MD cord-274141-vujx538o 493 10 be be VB cord-274141-vujx538o 493 11 done do VBN cord-274141-vujx538o 493 12 to to TO cord-274141-vujx538o 493 13 investigate investigate VB cord-274141-vujx538o 493 14 the the DT cord-274141-vujx538o 493 15 binding bind VBG cord-274141-vujx538o 493 16 affinities affinity NNS cord-274141-vujx538o 493 17 of of IN cord-274141-vujx538o 493 18 plant plant NN cord-274141-vujx538o 493 19 active active JJ cord-274141-vujx538o 493 20 compounds compound NNS cord-274141-vujx538o 493 21 to to IN cord-274141-vujx538o 493 22 SARS SARS NNP cord-274141-vujx538o 493 23 - - HYPH cord-274141-vujx538o 493 24 CoV-2 CoV-2 NNP cord-274141-vujx538o 493 25 . . . cord-274141-vujx538o 494 1 A a DT cord-274141-vujx538o 494 2 docking docking NN cord-274141-vujx538o 494 3 analysis analysis NN cord-274141-vujx538o 494 4 can can MD cord-274141-vujx538o 494 5 test test VB cord-274141-vujx538o 494 6 whether whether IN cord-274141-vujx538o 494 7 the the DT cord-274141-vujx538o 494 8 active active JJ cord-274141-vujx538o 494 9 compound compound NN cord-274141-vujx538o 494 10 has have VBZ cord-274141-vujx538o 494 11 the the DT cord-274141-vujx538o 494 12 potential potential NN cord-274141-vujx538o 494 13 to to TO cord-274141-vujx538o 494 14 directly directly RB cord-274141-vujx538o 494 15 interact interact VB cord-274141-vujx538o 494 16 with with IN cord-274141-vujx538o 494 17 SARS SARS NNP cord-274141-vujx538o 494 18 - - HYPH cord-274141-vujx538o 494 19 CoV-2 CoV-2 NNP cord-274141-vujx538o 494 20 proteins protein NNS cord-274141-vujx538o 494 21 ) ) -RRB- cord-274141-vujx538o 494 22 . . . cord-274141-vujx538o 495 1 Application application NN cord-274141-vujx538o 495 2 of of IN cord-274141-vujx538o 495 3 structure structure NN cord-274141-vujx538o 495 4 - - HYPH cord-274141-vujx538o 495 5 based base VBN cord-274141-vujx538o 495 6 drug drug NN cord-274141-vujx538o 495 7 design design NN cord-274141-vujx538o 495 8 strategies strategy NNS cord-274141-vujx538o 495 9 may may MD cord-274141-vujx538o 495 10 aid aid VB cord-274141-vujx538o 495 11 in in IN cord-274141-vujx538o 495 12 the the DT cord-274141-vujx538o 495 13 development development NN cord-274141-vujx538o 495 14 of of IN cord-274141-vujx538o 495 15 novel novel JJ cord-274141-vujx538o 495 16 SARS SARS NNP cord-274141-vujx538o 495 17 - - HYPH cord-274141-vujx538o 495 18 CoV-2 CoV-2 NNP cord-274141-vujx538o 495 19 inhibitors inhibitor NNS cord-274141-vujx538o 495 20 from from IN cord-274141-vujx538o 495 21 natural natural JJ cord-274141-vujx538o 495 22 compounds compound NNS cord-274141-vujx538o 495 23 . . . cord-274141-vujx538o 496 1 To to TO cord-274141-vujx538o 496 2 predict predict VB cord-274141-vujx538o 496 3 the the DT cord-274141-vujx538o 496 4 general general JJ cord-274141-vujx538o 496 5 in in IN cord-274141-vujx538o 496 6 vivo vivo NN cord-274141-vujx538o 496 7 effects effect NNS cord-274141-vujx538o 496 8 of of IN cord-274141-vujx538o 496 9 the the DT cord-274141-vujx538o 496 10 natural natural JJ cord-274141-vujx538o 496 11 compounds compound NNS cord-274141-vujx538o 496 12 , , , cord-274141-vujx538o 496 13 network network NN cord-274141-vujx538o 496 14 pharmacology pharmacology NN cord-274141-vujx538o 496 15 analysis analysis NN cord-274141-vujx538o 496 16 can can MD cord-274141-vujx538o 496 17 be be VB cord-274141-vujx538o 496 18 carried carry VBN cord-274141-vujx538o 496 19 out out RP cord-274141-vujx538o 496 20 . . . cord-274141-vujx538o 497 1 Only only RB cord-274141-vujx538o 497 2 0.0004 0.0004 CD cord-274141-vujx538o 497 3 % % NN cord-274141-vujx538o 497 4 plant plant NN cord-274141-vujx538o 497 5 samples sample NNS cord-274141-vujx538o 497 6 may may MD cord-274141-vujx538o 497 7 directly directly RB cord-274141-vujx538o 497 8 lead lead VB cord-274141-vujx538o 497 9 to to IN cord-274141-vujx538o 497 10 a a DT cord-274141-vujx538o 497 11 commercial commercial JJ cord-274141-vujx538o 497 12 drug drug NN cord-274141-vujx538o 497 13 ( ( -LRB- cord-274141-vujx538o 497 14 Chinsembu Chinsembu NNP cord-274141-vujx538o 497 15 2016a 2016a CD cord-274141-vujx538o 497 16 ) ) -RRB- cord-274141-vujx538o 497 17 . . . cord-274141-vujx538o 498 1 Thus thus RB cord-274141-vujx538o 498 2 , , , cord-274141-vujx538o 498 3 there there EX cord-274141-vujx538o 498 4 are be VBP cord-274141-vujx538o 498 5 few few JJ cord-274141-vujx538o 498 6 plantderived plantderived JJ cord-274141-vujx538o 498 7 anti anti JJ cord-274141-vujx538o 498 8 - - JJ cord-274141-vujx538o 498 9 SARS SARS NNP cord-274141-vujx538o 498 10 agents agent NNS cord-274141-vujx538o 498 11 in in IN cord-274141-vujx538o 498 12 clinical clinical JJ cord-274141-vujx538o 498 13 trials trial NNS cord-274141-vujx538o 498 14 . . . cord-274141-vujx538o 499 1 From from IN cord-274141-vujx538o 499 2 2012 2012 CD cord-274141-vujx538o 499 3 to to IN cord-274141-vujx538o 499 4 2017 2017 CD cord-274141-vujx538o 499 5 , , , cord-274141-vujx538o 499 6 only only RB cord-274141-vujx538o 499 7 twelve twelve CD cord-274141-vujx538o 499 8 new new JJ cord-274141-vujx538o 499 9 antivirals antiviral NNS cord-274141-vujx538o 499 10 were be VBD cord-274141-vujx538o 499 11 approved approve VBN cord-274141-vujx538o 499 12 by by IN cord-274141-vujx538o 499 13 the the DT cord-274141-vujx538o 499 14 US US NNP cord-274141-vujx538o 499 15 Food Food NNP cord-274141-vujx538o 499 16 and and CC cord-274141-vujx538o 499 17 Drug Drug NNP cord-274141-vujx538o 499 18 Administration Administration NNP cord-274141-vujx538o 499 19 ; ; : cord-274141-vujx538o 499 20 eight eight CD cord-274141-vujx538o 499 21 were be VBD cord-274141-vujx538o 499 22 for for IN cord-274141-vujx538o 499 23 the the DT cord-274141-vujx538o 499 24 treatment treatment NN cord-274141-vujx538o 499 25 of of IN cord-274141-vujx538o 499 26 pathologies pathology NNS cord-274141-vujx538o 499 27 related relate VBN cord-274141-vujx538o 499 28 to to IN cord-274141-vujx538o 499 29 hepatitis hepatitis NN cord-274141-vujx538o 499 30 C C NNP cord-274141-vujx538o 499 31 virus virus NN cord-274141-vujx538o 499 32 and and CC cord-274141-vujx538o 499 33 two two CD cord-274141-vujx538o 499 34 were be VBD cord-274141-vujx538o 499 35 combinations combination NNS cord-274141-vujx538o 499 36 of of IN cord-274141-vujx538o 499 37 anti anti JJ cord-274141-vujx538o 499 38 - - JJ cord-274141-vujx538o 499 39 HIV hiv JJ cord-274141-vujx538o 499 40 drugs drug NNS cord-274141-vujx538o 500 1 ( ( -LRB- cord-274141-vujx538o 500 2 Mercorelli Mercorelli NNP cord-274141-vujx538o 500 3 et et NNP cord-274141-vujx538o 500 4 al al NNP cord-274141-vujx538o 500 5 . . . cord-274141-vujx538o 500 6 2018 2018 CD cord-274141-vujx538o 500 7 ) ) -RRB- cord-274141-vujx538o 500 8 . . . cord-274141-vujx538o 501 1 Since since IN cord-274141-vujx538o 501 2 less less JJR cord-274141-vujx538o 501 3 than than IN cord-274141-vujx538o 501 4 15 15 CD cord-274141-vujx538o 501 5 % % NN cord-274141-vujx538o 501 6 of of IN cord-274141-vujx538o 501 7 plant plant NN cord-274141-vujx538o 501 8 diversity diversity NN cord-274141-vujx538o 501 9 has have VBZ cord-274141-vujx538o 501 10 been be VBN cord-274141-vujx538o 501 11 explored explore VBN cord-274141-vujx538o 501 12 for for IN cord-274141-vujx538o 501 13 pharmaceutical pharmaceutical JJ cord-274141-vujx538o 501 14 purposes purpose NNS cord-274141-vujx538o 501 15 ( ( -LRB- cord-274141-vujx538o 501 16 Chinsembu Chinsembu NNP cord-274141-vujx538o 501 17 , , , cord-274141-vujx538o 501 18 2016a 2016a CD cord-274141-vujx538o 501 19 ) ) -RRB- cord-274141-vujx538o 501 20 , , , cord-274141-vujx538o 501 21 the the DT cord-274141-vujx538o 501 22 transition transition NN cord-274141-vujx538o 501 23 from from IN cord-274141-vujx538o 501 24 natural natural JJ cord-274141-vujx538o 501 25 product product NN cord-274141-vujx538o 501 26 to to IN cord-274141-vujx538o 501 27 anti anti JJ cord-274141-vujx538o 501 28 - - JJ cord-274141-vujx538o 501 29 SARS SARS NNP cord-274141-vujx538o 501 30 - - HYPH cord-274141-vujx538o 501 31 CoV-2 CoV-2 NNP cord-274141-vujx538o 501 32 drug drug NN cord-274141-vujx538o 501 33 prototypes prototype NNS cord-274141-vujx538o 501 34 is be VBZ cord-274141-vujx538o 501 35 a a DT cord-274141-vujx538o 501 36 daunting daunting JJ cord-274141-vujx538o 501 37 reality reality NN cord-274141-vujx538o 501 38 as as RB cord-274141-vujx538o 501 39 much much RB cord-274141-vujx538o 501 40 as as IN cord-274141-vujx538o 501 41 it -PRON- PRP cord-274141-vujx538o 501 42 is be VBZ cord-274141-vujx538o 501 43 a a DT cord-274141-vujx538o 501 44 beautiful beautiful JJ cord-274141-vujx538o 501 45 prospect prospect NN cord-274141-vujx538o 501 46 . . . cord-274141-vujx538o 502 1 This this DT cord-274141-vujx538o 502 2 review review NN cord-274141-vujx538o 502 3 shows show VBZ cord-274141-vujx538o 502 4 that that IN cord-274141-vujx538o 502 5 plants plant NNS cord-274141-vujx538o 502 6 , , , cord-274141-vujx538o 502 7 fungi fungus NNS cord-274141-vujx538o 502 8 , , , cord-274141-vujx538o 502 9 and and CC cord-274141-vujx538o 502 10 marine marine JJ cord-274141-vujx538o 502 11 organisms organism NNS cord-274141-vujx538o 502 12 have have VBP cord-274141-vujx538o 502 13 anti anti JJ cord-274141-vujx538o 502 14 - - JJ cord-274141-vujx538o 502 15 SARS SARS NNP cord-274141-vujx538o 502 16 - - HYPH cord-274141-vujx538o 502 17 CoV CoV NNP cord-274141-vujx538o 502 18 properties property NNS cord-274141-vujx538o 502 19 . . . cord-274141-vujx538o 503 1 Many many JJ cord-274141-vujx538o 503 2 of of IN cord-274141-vujx538o 503 3 these these DT cord-274141-vujx538o 503 4 plants plant NNS cord-274141-vujx538o 503 5 , , , cord-274141-vujx538o 503 6 fungi fungus NNS cord-274141-vujx538o 503 7 , , , cord-274141-vujx538o 503 8 and and CC cord-274141-vujx538o 503 9 marine marine JJ cord-274141-vujx538o 503 10 organisms organism NNS cord-274141-vujx538o 503 11 have have VBP cord-274141-vujx538o 503 12 other other JJ cord-274141-vujx538o 503 13 pharmacological pharmacological JJ cord-274141-vujx538o 503 14 benefits benefit NNS cord-274141-vujx538o 503 15 because because IN cord-274141-vujx538o 503 16 structural structural JJ cord-274141-vujx538o 503 17 diversity diversity NN cord-274141-vujx538o 503 18 and and CC cord-274141-vujx538o 503 19 adaptation adaptation NN cord-274141-vujx538o 503 20 to to IN cord-274141-vujx538o 503 21 various various JJ cord-274141-vujx538o 503 22 environmental environmental JJ cord-274141-vujx538o 503 23 conditions condition NNS cord-274141-vujx538o 503 24 induce induce VBP cord-274141-vujx538o 503 25 them -PRON- PRP cord-274141-vujx538o 503 26 to to TO cord-274141-vujx538o 503 27 synthesize synthesize VB cord-274141-vujx538o 503 28 defensive defensive JJ cord-274141-vujx538o 503 29 compounds compound NNS cord-274141-vujx538o 503 30 with with IN cord-274141-vujx538o 503 31 assorted assorted JJ cord-274141-vujx538o 503 32 biological biological JJ cord-274141-vujx538o 503 33 activities activity NNS cord-274141-vujx538o 504 1 ( ( -LRB- cord-274141-vujx538o 504 2 Prinsloo Prinsloo NNP cord-274141-vujx538o 504 3 et et NNP cord-274141-vujx538o 504 4 al al NNP cord-274141-vujx538o 504 5 . . . cord-274141-vujx538o 504 6 2018 2018 CD cord-274141-vujx538o 504 7 ) ) -RRB- cord-274141-vujx538o 504 8 . . . cord-274141-vujx538o 505 1 Corollary corollary JJ cord-274141-vujx538o 505 2 , , , cord-274141-vujx538o 505 3 diverse diverse JJ cord-274141-vujx538o 505 4 plant plant NN cord-274141-vujx538o 505 5 secondary secondary JJ cord-274141-vujx538o 505 6 metabolites metabolite NNS cord-274141-vujx538o 505 7 are be VBP cord-274141-vujx538o 505 8 an an DT cord-274141-vujx538o 505 9 important important JJ cord-274141-vujx538o 505 10 library library NN cord-274141-vujx538o 505 11 of of IN cord-274141-vujx538o 505 12 novel novel JJ cord-274141-vujx538o 505 13 lead lead NN cord-274141-vujx538o 505 14 compounds compound NNS cord-274141-vujx538o 505 15 that that WDT cord-274141-vujx538o 505 16 may may MD cord-274141-vujx538o 505 17 be be VB cord-274141-vujx538o 505 18 functional functional JJ cord-274141-vujx538o 505 19 against against IN cord-274141-vujx538o 505 20 SARS SARS NNP cord-274141-vujx538o 505 21 - - HYPH cord-274141-vujx538o 505 22 CoV-2 CoV-2 NNP cord-274141-vujx538o 505 23 . . . cord-274141-vujx538o 506 1 Bio Bio NNP cord-274141-vujx538o 506 2 - - HYPH cord-274141-vujx538o 506 3 assay assay NN cord-274141-vujx538o 506 4 - - HYPH cord-274141-vujx538o 506 5 guided guide VBN cord-274141-vujx538o 506 6 fractionation fractionation NN cord-274141-vujx538o 506 7 of of IN cord-274141-vujx538o 506 8 medicinal medicinal JJ cord-274141-vujx538o 506 9 plant plant NN cord-274141-vujx538o 506 10 extracts extract NNS cord-274141-vujx538o 506 11 may may MD cord-274141-vujx538o 506 12 provide provide VB cord-274141-vujx538o 506 13 a a DT cord-274141-vujx538o 506 14 quicker quick JJR cord-274141-vujx538o 506 15 pipeline pipeline NN cord-274141-vujx538o 506 16 for for IN cord-274141-vujx538o 506 17 the the DT cord-274141-vujx538o 506 18 discovery discovery NN cord-274141-vujx538o 506 19 of of IN cord-274141-vujx538o 506 20 novel novel JJ cord-274141-vujx538o 506 21 compounds compound NNS cord-274141-vujx538o 506 22 against against IN cord-274141-vujx538o 506 23 SARS SARS NNP cord-274141-vujx538o 506 24 - - HYPH cord-274141-vujx538o 506 25 CoV-2 CoV-2 NNP cord-274141-vujx538o 506 26 . . . cord-274141-vujx538o 507 1 An an DT cord-274141-vujx538o 507 2 examination examination NN cord-274141-vujx538o 507 3 of of IN cord-274141-vujx538o 507 4 the the DT cord-274141-vujx538o 507 5 research research NN cord-274141-vujx538o 507 6 publications publication NNS cord-274141-vujx538o 507 7 on on IN cord-274141-vujx538o 507 8 anti anti JJ cord-274141-vujx538o 507 9 - - JJ cord-274141-vujx538o 507 10 SARS sars JJ cord-274141-vujx538o 507 11 natural natural JJ cord-274141-vujx538o 507 12 products product NNS cord-274141-vujx538o 507 13 cited cite VBN cord-274141-vujx538o 507 14 in in IN cord-274141-vujx538o 507 15 this this DT cord-274141-vujx538o 507 16 review review NN cord-274141-vujx538o 507 17 shows show VBZ cord-274141-vujx538o 507 18 that that IN cord-274141-vujx538o 507 19 about about RB cord-274141-vujx538o 507 20 8 8 CD cord-274141-vujx538o 507 21 out out IN cord-274141-vujx538o 507 22 of of IN cord-274141-vujx538o 507 23 10 10 CD cord-274141-vujx538o 507 24 are be VBP cord-274141-vujx538o 507 25 authored author VBN cord-274141-vujx538o 507 26 by by IN cord-274141-vujx538o 507 27 the the DT cord-274141-vujx538o 507 28 Chinese Chinese NNPS cord-274141-vujx538o 507 29 . . . cord-274141-vujx538o 508 1 Since since IN cord-274141-vujx538o 508 2 the the DT cord-274141-vujx538o 508 3 Chinese Chinese NNPS cord-274141-vujx538o 508 4 represent represent VBP cord-274141-vujx538o 508 5 about about RB cord-274141-vujx538o 508 6 80 80 CD cord-274141-vujx538o 508 7 % % NN cord-274141-vujx538o 508 8 of of IN cord-274141-vujx538o 508 9 all all DT cord-274141-vujx538o 508 10 research research NN cord-274141-vujx538o 508 11 efforts effort NNS cord-274141-vujx538o 508 12 and and CC cord-274141-vujx538o 508 13 publications publication NNS cord-274141-vujx538o 508 14 on on IN cord-274141-vujx538o 508 15 anti anti JJ cord-274141-vujx538o 508 16 - - JJ cord-274141-vujx538o 508 17 SARS sars JJ cord-274141-vujx538o 508 18 natural natural JJ cord-274141-vujx538o 508 19 products product NNS cord-274141-vujx538o 508 20 , , , cord-274141-vujx538o 508 21 there there EX cord-274141-vujx538o 508 22 is be VBZ cord-274141-vujx538o 508 23 80 80 CD cord-274141-vujx538o 508 24 % % NN cord-274141-vujx538o 508 25 chance chance NN cord-274141-vujx538o 508 26 that that IN cord-274141-vujx538o 508 27 the the DT cord-274141-vujx538o 508 28 next next JJ cord-274141-vujx538o 508 29 big big JJ cord-274141-vujx538o 508 30 discovery discovery NN cord-274141-vujx538o 508 31 of of IN cord-274141-vujx538o 508 32 novel novel JJ cord-274141-vujx538o 508 33 natural natural JJ cord-274141-vujx538o 508 34 products product NNS cord-274141-vujx538o 508 35 to to TO cord-274141-vujx538o 508 36 treat treat VB cord-274141-vujx538o 508 37 COVID-19 COVID-19 NNP cord-274141-vujx538o 508 38 will will MD cord-274141-vujx538o 508 39 be be VB cord-274141-vujx538o 508 40 from from IN cord-274141-vujx538o 508 41 TCM TCM NNP cord-274141-vujx538o 508 42 . . . cord-274141-vujx538o 509 1 China China NNP cord-274141-vujx538o 509 2 is be VBZ cord-274141-vujx538o 509 3 the the DT cord-274141-vujx538o 509 4 world world NN cord-274141-vujx538o 509 5 leader leader NN cord-274141-vujx538o 509 6 in in IN cord-274141-vujx538o 509 7 research research NN cord-274141-vujx538o 509 8 and and CC cord-274141-vujx538o 509 9 development development NN cord-274141-vujx538o 509 10 for for IN cord-274141-vujx538o 509 11 innovative innovative JJ cord-274141-vujx538o 509 12 anti anti JJ cord-274141-vujx538o 509 13 - - JJ cord-274141-vujx538o 509 14 SARS SARS NNP cord-274141-vujx538o 509 15 agents agent NNS cord-274141-vujx538o 509 16 from from IN cord-274141-vujx538o 509 17 natural natural JJ cord-274141-vujx538o 509 18 products product NNS cord-274141-vujx538o 509 19 . . . cord-274141-vujx538o 510 1 By by IN cord-274141-vujx538o 510 2 all all DT cord-274141-vujx538o 510 3 intents intent NNS cord-274141-vujx538o 510 4 and and CC cord-274141-vujx538o 510 5 purposes purpose NNS cord-274141-vujx538o 510 6 , , , cord-274141-vujx538o 510 7 the the DT cord-274141-vujx538o 510 8 first first JJ cord-274141-vujx538o 510 9 wellresearched wellresearched JJ cord-274141-vujx538o 510 10 and and CC cord-274141-vujx538o 510 11 clinically clinically RB cord-274141-vujx538o 510 12 proven prove VBN cord-274141-vujx538o 510 13 herbal herbal JJ cord-274141-vujx538o 510 14 remedy remedy NN cord-274141-vujx538o 510 15 for for IN cord-274141-vujx538o 510 16 COVID-19 COVID-19 NNP cord-274141-vujx538o 510 17 will will MD cord-274141-vujx538o 510 18 most most RBS cord-274141-vujx538o 510 19 likely likely RB cord-274141-vujx538o 510 20 be be VB cord-274141-vujx538o 510 21 discovered discover VBN cord-274141-vujx538o 510 22 and and CC cord-274141-vujx538o 510 23 developed develop VBN cord-274141-vujx538o 510 24 in in IN cord-274141-vujx538o 510 25 China China NNP cord-274141-vujx538o 510 26 . . . cord-274141-vujx538o 511 1 The the DT cord-274141-vujx538o 511 2 most most RBS cord-274141-vujx538o 511 3 notable notable JJ cord-274141-vujx538o 511 4 gap gap NN cord-274141-vujx538o 511 5 identified identify VBN cord-274141-vujx538o 511 6 in in IN cord-274141-vujx538o 511 7 the the DT cord-274141-vujx538o 511 8 current current JJ cord-274141-vujx538o 511 9 literature literature NN cord-274141-vujx538o 511 10 is be VBZ cord-274141-vujx538o 511 11 that that IN cord-274141-vujx538o 511 12 many many JJ cord-274141-vujx538o 511 13 countries country NNS cord-274141-vujx538o 511 14 in in IN cord-274141-vujx538o 511 15 Africa Africa NNP cord-274141-vujx538o 511 16 , , , cord-274141-vujx538o 511 17 Asia Asia NNP cord-274141-vujx538o 511 18 ( ( -LRB- cord-274141-vujx538o 511 19 except except IN cord-274141-vujx538o 511 20 China China NNP cord-274141-vujx538o 511 21 ) ) -RRB- cord-274141-vujx538o 511 22 , , , cord-274141-vujx538o 511 23 Australia/ Australia/ NNP cord-274141-vujx538o 511 24 Oceania Oceania NNP cord-274141-vujx538o 511 25 , , , cord-274141-vujx538o 511 26 Europe Europe NNP cord-274141-vujx538o 511 27 , , , cord-274141-vujx538o 511 28 North North NNP cord-274141-vujx538o 511 29 America America NNP cord-274141-vujx538o 511 30 , , , cord-274141-vujx538o 511 31 and and CC cord-274141-vujx538o 511 32 South South NNP cord-274141-vujx538o 511 33 America America NNP cord-274141-vujx538o 511 34 lag lag VBP cord-274141-vujx538o 511 35 behind behind RB cord-274141-vujx538o 511 36 in in IN cord-274141-vujx538o 511 37 terms term NNS cord-274141-vujx538o 511 38 of of IN cord-274141-vujx538o 511 39 research research NN cord-274141-vujx538o 511 40 efforts effort NNS cord-274141-vujx538o 511 41 on on IN cord-274141-vujx538o 511 42 anti anti JJ cord-274141-vujx538o 511 43 - - JJ cord-274141-vujx538o 511 44 coronavirus coronavirus JJ cord-274141-vujx538o 511 45 remedies remedy NNS cord-274141-vujx538o 511 46 from from IN cord-274141-vujx538o 511 47 medicinal medicinal JJ cord-274141-vujx538o 511 48 plants plant NNS cord-274141-vujx538o 511 49 and and CC cord-274141-vujx538o 511 50 other other JJ cord-274141-vujx538o 511 51 natural natural JJ cord-274141-vujx538o 511 52 products product NNS cord-274141-vujx538o 511 53 . . . cord-274141-vujx538o 512 1 In in IN cord-274141-vujx538o 512 2 many many JJ cord-274141-vujx538o 512 3 countries country NNS cord-274141-vujx538o 512 4 all all RB cord-274141-vujx538o 512 5 over over IN cord-274141-vujx538o 512 6 the the DT cord-274141-vujx538o 512 7 world world NN cord-274141-vujx538o 512 8 , , , cord-274141-vujx538o 512 9 there there EX cord-274141-vujx538o 512 10 is be VBZ cord-274141-vujx538o 512 11 need need NN cord-274141-vujx538o 512 12 to to TO cord-274141-vujx538o 512 13 conduct conduct VB cord-274141-vujx538o 512 14 detailed detailed JJ cord-274141-vujx538o 512 15 ethnobotanical ethnobotanical JJ cord-274141-vujx538o 512 16 studies study NNS cord-274141-vujx538o 512 17 to to TO cord-274141-vujx538o 512 18 establish establish VB cord-274141-vujx538o 512 19 putative putative JJ cord-274141-vujx538o 512 20 anti anti JJ cord-274141-vujx538o 512 21 - - JJ cord-274141-vujx538o 512 22 SARS SARS NNP cord-274141-vujx538o 512 23 - - HYPH cord-274141-vujx538o 512 24 CoV-2 CoV-2 NNP cord-274141-vujx538o 512 25 medicinal medicinal JJ cord-274141-vujx538o 512 26 plants plant NNS cord-274141-vujx538o 512 27 and and CC cord-274141-vujx538o 512 28 their -PRON- PRP$ cord-274141-vujx538o 512 29 active active JJ cord-274141-vujx538o 512 30 compounds compound NNS cord-274141-vujx538o 512 31 . . . cord-274141-vujx538o 513 1 The the DT cord-274141-vujx538o 513 2 search search NN cord-274141-vujx538o 513 3 for for IN cord-274141-vujx538o 513 4 new new JJ cord-274141-vujx538o 513 5 anti anti JJ cord-274141-vujx538o 513 6 - - JJ cord-274141-vujx538o 513 7 SARS SARS NNP cord-274141-vujx538o 513 8 - - HYPH cord-274141-vujx538o 513 9 CoV-2 CoV-2 NNP cord-274141-vujx538o 513 10 agents agent NNS cord-274141-vujx538o 513 11 should should MD cord-274141-vujx538o 513 12 be be VB cord-274141-vujx538o 513 13 rigorously rigorously RB cord-274141-vujx538o 513 14 extended extend VBN cord-274141-vujx538o 513 15 to to IN cord-274141-vujx538o 513 16 marine marine JJ cord-274141-vujx538o 513 17 organisms organism NNS cord-274141-vujx538o 513 18 . . . cord-274141-vujx538o 514 1 This this DT cord-274141-vujx538o 514 2 review review NN cord-274141-vujx538o 514 3 shows show VBZ cord-274141-vujx538o 514 4 that that IN cord-274141-vujx538o 514 5 there there EX cord-274141-vujx538o 514 6 is be VBZ cord-274141-vujx538o 514 7 a a DT cord-274141-vujx538o 514 8 dearth dearth NN cord-274141-vujx538o 514 9 of of IN cord-274141-vujx538o 514 10 experimental experimental JJ cord-274141-vujx538o 514 11 data datum NNS cord-274141-vujx538o 514 12 on on IN cord-274141-vujx538o 514 13 posology posology NN cord-274141-vujx538o 514 14 and and CC cord-274141-vujx538o 514 15 cytotoxicity cytotoxicity NN cord-274141-vujx538o 514 16 of of IN cord-274141-vujx538o 514 17 plant plant NN cord-274141-vujx538o 514 18 extracts extract NNS cord-274141-vujx538o 514 19 and and CC cord-274141-vujx538o 514 20 active active JJ cord-274141-vujx538o 514 21 compounds compound NNS cord-274141-vujx538o 514 22 with with IN cord-274141-vujx538o 514 23 in in FW cord-274141-vujx538o 514 24 vitro vitro FW cord-274141-vujx538o 514 25 activity activity NN cord-274141-vujx538o 514 26 against against IN cord-274141-vujx538o 514 27 SARS SARS NNP cord-274141-vujx538o 514 28 - - HYPH cord-274141-vujx538o 514 29 CoV-2 CoV-2 NNP cord-274141-vujx538o 514 30 . . . cord-274141-vujx538o 515 1 More More JJR cord-274141-vujx538o 515 2 studies study NNS cord-274141-vujx538o 515 3 on on IN cord-274141-vujx538o 515 4 pan pan NN cord-274141-vujx538o 515 5 - - JJ cord-274141-vujx538o 515 6 assay assay NN cord-274141-vujx538o 515 7 interference interference NN cord-274141-vujx538o 515 8 compounds compound NNS cord-274141-vujx538o 515 9 ( ( -LRB- cord-274141-vujx538o 515 10 PAINS pain NNS cord-274141-vujx538o 515 11 ) ) -RRB- cord-274141-vujx538o 515 12 and and CC cord-274141-vujx538o 515 13 SARS SARS NNP cord-274141-vujx538o 515 14 - - HYPH cord-274141-vujx538o 515 15 CoV-2 CoV-2 NNP cord-274141-vujx538o 515 16 immunomodulatory immunomodulatory JJ cord-274141-vujx538o 515 17 agents agent NNS cord-274141-vujx538o 515 18 from from IN cord-274141-vujx538o 515 19 plants plant NNS cord-274141-vujx538o 515 20 and and CC cord-274141-vujx538o 515 21 other other JJ cord-274141-vujx538o 515 22 natural natural JJ cord-274141-vujx538o 515 23 products product NNS cord-274141-vujx538o 515 24 should should MD cord-274141-vujx538o 515 25 be be VB cord-274141-vujx538o 515 26 conducted conduct VBN cord-274141-vujx538o 515 27 . . . cord-274141-vujx538o 516 1 There there EX cord-274141-vujx538o 516 2 is be VBZ cord-274141-vujx538o 516 3 also also RB cord-274141-vujx538o 516 4 lack lack NN cord-274141-vujx538o 516 5 of of IN cord-274141-vujx538o 516 6 pharmacological pharmacological JJ cord-274141-vujx538o 516 7 and and CC cord-274141-vujx538o 516 8 rigorous rigorous JJ cord-274141-vujx538o 516 9 human human JJ cord-274141-vujx538o 516 10 clinical clinical JJ cord-274141-vujx538o 516 11 trial trial NN cord-274141-vujx538o 516 12 data datum NNS cord-274141-vujx538o 516 13 in in IN cord-274141-vujx538o 516 14 relation relation NN cord-274141-vujx538o 516 15 to to IN cord-274141-vujx538o 516 16 natural natural JJ cord-274141-vujx538o 516 17 products product NNS cord-274141-vujx538o 516 18 for for IN cord-274141-vujx538o 516 19 treating treat VBG cord-274141-vujx538o 516 20 COVID-19 covid-19 NN cord-274141-vujx538o 516 21 . . . cord-274141-vujx538o 517 1 The the DT cord-274141-vujx538o 517 2 world world NN cord-274141-vujx538o 517 3 is be VBZ cord-274141-vujx538o 517 4 in in IN cord-274141-vujx538o 517 5 the the DT cord-274141-vujx538o 517 6 middle middle NN cord-274141-vujx538o 517 7 of of IN cord-274141-vujx538o 517 8 a a DT cord-274141-vujx538o 517 9 COVID-19 covid-19 CD cord-274141-vujx538o 517 10 pandemic pandemic NN cord-274141-vujx538o 517 11 . . . cord-274141-vujx538o 518 1 Although although IN cord-274141-vujx538o 518 2 the the DT cord-274141-vujx538o 518 3 deadly deadly JJ cord-274141-vujx538o 518 4 threat threat NN cord-274141-vujx538o 518 5 posed pose VBN cord-274141-vujx538o 518 6 by by IN cord-274141-vujx538o 518 7 the the DT cord-274141-vujx538o 518 8 current current JJ cord-274141-vujx538o 518 9 COVID-19 COVID-19 NNP cord-274141-vujx538o 518 10 pandemic pandemic NN cord-274141-vujx538o 518 11 requires require VBZ cord-274141-vujx538o 518 12 the the DT cord-274141-vujx538o 518 13 development development NN cord-274141-vujx538o 518 14 of of IN cord-274141-vujx538o 518 15 new new JJ cord-274141-vujx538o 518 16 therapeutic therapeutic JJ cord-274141-vujx538o 518 17 agents agent NNS cord-274141-vujx538o 518 18 , , , cord-274141-vujx538o 518 19 there there EX cord-274141-vujx538o 518 20 are be VBP cord-274141-vujx538o 518 21 currently currently RB cord-274141-vujx538o 518 22 no no DT cord-274141-vujx538o 518 23 efficacious efficacious JJ cord-274141-vujx538o 518 24 and and CC cord-274141-vujx538o 518 25 safe safe JJ cord-274141-vujx538o 518 26 vaccines vaccine NNS cord-274141-vujx538o 518 27 or or CC cord-274141-vujx538o 518 28 drugs drug NNS cord-274141-vujx538o 518 29 to to TO cord-274141-vujx538o 518 30 prevent prevent VB cord-274141-vujx538o 518 31 or or CC cord-274141-vujx538o 518 32 treat treat VB cord-274141-vujx538o 518 33 this this DT cord-274141-vujx538o 518 34 highly highly RB cord-274141-vujx538o 518 35 infectious infectious JJ cord-274141-vujx538o 518 36 disease disease NN cord-274141-vujx538o 518 37 . . . cord-274141-vujx538o 519 1 Even even RB cord-274141-vujx538o 519 2 in in IN cord-274141-vujx538o 519 3 developed develop VBN cord-274141-vujx538o 519 4 nations nation NNS cord-274141-vujx538o 519 5 , , , cord-274141-vujx538o 519 6 blockbuster blockbuster JJ cord-274141-vujx538o 519 7 vaccines vaccine NNS cord-274141-vujx538o 519 8 or or CC cord-274141-vujx538o 519 9 drugs drug NNS cord-274141-vujx538o 519 10 have have VBP cord-274141-vujx538o 519 11 not not RB cord-274141-vujx538o 519 12 yet yet RB cord-274141-vujx538o 519 13 been be VBN cord-274141-vujx538o 519 14 developed develop VBN cord-274141-vujx538o 519 15 or or CC cord-274141-vujx538o 519 16 approved approve VBN cord-274141-vujx538o 519 17 for for IN cord-274141-vujx538o 519 18 the the DT cord-274141-vujx538o 519 19 prevention prevention NN cord-274141-vujx538o 519 20 and and CC cord-274141-vujx538o 519 21 treatment treatment NN cord-274141-vujx538o 519 22 of of IN cord-274141-vujx538o 519 23 COVID-19 COVID-19 NNP cord-274141-vujx538o 519 24 . . . cord-274141-vujx538o 520 1 Only only RB cord-274141-vujx538o 520 2 one one CD cord-274141-vujx538o 520 3 synthetic synthetic JJ cord-274141-vujx538o 520 4 drug drug NN cord-274141-vujx538o 520 5 ( ( -LRB- cord-274141-vujx538o 520 6 remdesivir remdesivir NNP cord-274141-vujx538o 520 7 ) ) -RRB- cord-274141-vujx538o 520 8 has have VBZ cord-274141-vujx538o 520 9 been be VBN cord-274141-vujx538o 520 10 approved approve VBN cord-274141-vujx538o 520 11 for for IN cord-274141-vujx538o 520 12 emergency emergency NN cord-274141-vujx538o 520 13 use use NN cord-274141-vujx538o 520 14 in in IN cord-274141-vujx538o 520 15 the the DT cord-274141-vujx538o 520 16 USA USA NNP cord-274141-vujx538o 520 17 . . . cord-274141-vujx538o 521 1 Compared compare VBN cord-274141-vujx538o 521 2 with with IN cord-274141-vujx538o 521 3 placebo placebo NN cord-274141-vujx538o 521 4 , , , cord-274141-vujx538o 521 5 remdesivir remdesivir NNP cord-274141-vujx538o 521 6 did do VBD cord-274141-vujx538o 521 7 not not RB cord-274141-vujx538o 521 8 significantly significantly RB cord-274141-vujx538o 521 9 reduce reduce VB cord-274141-vujx538o 521 10 the the DT cord-274141-vujx538o 521 11 mortality mortality NN cord-274141-vujx538o 521 12 of of IN cord-274141-vujx538o 521 13 COVID-19 covid-19 JJ cord-274141-vujx538o 521 14 patients patient NNS cord-274141-vujx538o 521 15 in in IN cord-274141-vujx538o 521 16 clinical clinical JJ cord-274141-vujx538o 521 17 trials trial NNS cord-274141-vujx538o 521 18 . . . cord-274141-vujx538o 522 1 Against against IN cord-274141-vujx538o 522 2 this this DT cord-274141-vujx538o 522 3 backdrop backdrop NN cord-274141-vujx538o 522 4 , , , cord-274141-vujx538o 522 5 this this DT cord-274141-vujx538o 522 6 review review NN cord-274141-vujx538o 522 7 provides provide VBZ cord-274141-vujx538o 522 8 a a DT cord-274141-vujx538o 522 9 modest modest JJ cord-274141-vujx538o 522 10 but but CC cord-274141-vujx538o 522 11 insightful insightful JJ cord-274141-vujx538o 522 12 snapshot snapshot NN cord-274141-vujx538o 522 13 of of IN cord-274141-vujx538o 522 14 medicinal medicinal JJ cord-274141-vujx538o 522 15 plants plant NNS cord-274141-vujx538o 522 16 , , , cord-274141-vujx538o 522 17 fungi fungus NNS cord-274141-vujx538o 522 18 , , , cord-274141-vujx538o 522 19 and and CC cord-274141-vujx538o 522 20 marine marine JJ cord-274141-vujx538o 522 21 organisms organism NNS cord-274141-vujx538o 522 22 that that WDT cord-274141-vujx538o 522 23 contain contain VBP cord-274141-vujx538o 522 24 putative putative JJ cord-274141-vujx538o 522 25 active active JJ cord-274141-vujx538o 522 26 compounds compound NNS cord-274141-vujx538o 522 27 that that WDT cord-274141-vujx538o 522 28 inhibit inhibit VBP cord-274141-vujx538o 522 29 SARS SARS NNP cord-274141-vujx538o 522 30 - - HYPH cord-274141-vujx538o 522 31 CoV-2 CoV-2 NNP cord-274141-vujx538o 522 32 . . . cord-274141-vujx538o 523 1 Data datum NNS cord-274141-vujx538o 523 2 in in IN cord-274141-vujx538o 523 3 this this DT cord-274141-vujx538o 523 4 review review NN cord-274141-vujx538o 523 5 show show NN cord-274141-vujx538o 523 6 two two CD cord-274141-vujx538o 523 7 recurring recur VBG cord-274141-vujx538o 523 8 motifs motif NNS cord-274141-vujx538o 523 9 . . . cord-274141-vujx538o 524 1 The the DT cord-274141-vujx538o 524 2 first first JJ cord-274141-vujx538o 524 3 one one NN cord-274141-vujx538o 524 4 is be VBZ cord-274141-vujx538o 524 5 that that IN cord-274141-vujx538o 524 6 the the DT cord-274141-vujx538o 524 7 search search NN cord-274141-vujx538o 524 8 for for IN cord-274141-vujx538o 524 9 herbal herbal JJ cord-274141-vujx538o 524 10 remedies remedy NNS cord-274141-vujx538o 524 11 against against IN cord-274141-vujx538o 524 12 COVID-19 COVID-19 NNP cord-274141-vujx538o 524 13 is be VBZ cord-274141-vujx538o 524 14 more more RBR cord-274141-vujx538o 524 15 intense intense JJ cord-274141-vujx538o 524 16 in in IN cord-274141-vujx538o 524 17 China China NNP cord-274141-vujx538o 524 18 than than IN cord-274141-vujx538o 524 19 in in IN cord-274141-vujx538o 524 20 any any DT cord-274141-vujx538o 524 21 other other JJ cord-274141-vujx538o 524 22 part part NN cord-274141-vujx538o 524 23 of of IN cord-274141-vujx538o 524 24 the the DT cord-274141-vujx538o 524 25 world world NN cord-274141-vujx538o 524 26 . . . cord-274141-vujx538o 525 1 The the DT cord-274141-vujx538o 525 2 second second JJ cord-274141-vujx538o 525 3 is be VBZ cord-274141-vujx538o 525 4 that that IN cord-274141-vujx538o 525 5 most most JJS cord-274141-vujx538o 525 6 putative putative JJ cord-274141-vujx538o 525 7 anti anti JJ cord-274141-vujx538o 525 8 - - JJ cord-274141-vujx538o 525 9 SARS SARS NNP cord-274141-vujx538o 525 10 - - HYPH cord-274141-vujx538o 525 11 CoV-2 CoV-2 NNP cord-274141-vujx538o 525 12 remedies remedy NNS cord-274141-vujx538o 525 13 contain contain VBP cord-274141-vujx538o 525 14 active active JJ cord-274141-vujx538o 525 15 compounds compound NNS cord-274141-vujx538o 525 16 that that WDT cord-274141-vujx538o 525 17 inhibit inhibit VBP cord-274141-vujx538o 525 18 HCoVs hcovs CD cord-274141-vujx538o 525 19 at at IN cord-274141-vujx538o 525 20 the the DT cord-274141-vujx538o 525 21 cellular cellular JJ cord-274141-vujx538o 525 22 and and CC cord-274141-vujx538o 525 23 molecular molecular JJ cord-274141-vujx538o 525 24 levels level NNS cord-274141-vujx538o 525 25 . . . cord-274141-vujx538o 526 1 Since since IN cord-274141-vujx538o 526 2 structure structure NN cord-274141-vujx538o 526 3 dictates dictate VBZ cord-274141-vujx538o 526 4 function function VBP cord-274141-vujx538o 526 5 , , , cord-274141-vujx538o 526 6 many many JJ cord-274141-vujx538o 526 7 of of IN cord-274141-vujx538o 526 8 these these DT cord-274141-vujx538o 526 9 compounds compound NNS cord-274141-vujx538o 526 10 inhibit inhibit VBP cord-274141-vujx538o 526 11 SARS SARS NNP cord-274141-vujx538o 526 12 - - HYPH cord-274141-vujx538o 526 13 CoV cov NN cord-274141-vujx538o 526 14 replication replication NN cord-274141-vujx538o 526 15 because because IN cord-274141-vujx538o 526 16 their -PRON- PRP$ cord-274141-vujx538o 526 17 chemical chemical NN cord-274141-vujx538o 526 18 structures structure NNS cord-274141-vujx538o 526 19 mimic mimic VBP cord-274141-vujx538o 526 20 nucleoside nucleoside JJ cord-274141-vujx538o 526 21 analogues analogue NNS cord-274141-vujx538o 526 22 . . . cord-274141-vujx538o 527 1 While while IN cord-274141-vujx538o 527 2 many many JJ cord-274141-vujx538o 527 3 of of IN cord-274141-vujx538o 527 4 the the DT cord-274141-vujx538o 527 5 natural natural JJ cord-274141-vujx538o 527 6 products product NNS cord-274141-vujx538o 527 7 possess possess VBP cord-274141-vujx538o 527 8 anti anti JJ cord-274141-vujx538o 527 9 - - JJ cord-274141-vujx538o 527 10 SARS SARS NNP cord-274141-vujx538o 527 11 - - HYPH cord-274141-vujx538o 527 12 CoV CoV NNP cord-274141-vujx538o 527 13 properties property NNS cord-274141-vujx538o 527 14 , , , cord-274141-vujx538o 527 15 their -PRON- PRP$ cord-274141-vujx538o 527 16 extracts extract NNS cord-274141-vujx538o 527 17 and and CC cord-274141-vujx538o 527 18 active active JJ cord-274141-vujx538o 527 19 compounds compound NNS cord-274141-vujx538o 527 20 should should MD cord-274141-vujx538o 527 21 be be VB cord-274141-vujx538o 527 22 evaluated evaluate VBN cord-274141-vujx538o 527 23 for for IN cord-274141-vujx538o 527 24 human human JJ cord-274141-vujx538o 527 25 cytotoxicity cytotoxicity NN cord-274141-vujx538o 527 26 and and CC cord-274141-vujx538o 527 27 dosage dosage NN cord-274141-vujx538o 527 28 . . . cord-274141-vujx538o 528 1 Putative putative JJ cord-274141-vujx538o 528 2 anti anti JJ cord-274141-vujx538o 528 3 - - JJ cord-274141-vujx538o 528 4 SARS SARS NNP cord-274141-vujx538o 528 5 - - HYPH cord-274141-vujx538o 528 6 CoV-2 CoV-2 NNP cord-274141-vujx538o 528 7 extracts extract NNS cord-274141-vujx538o 528 8 and and CC cord-274141-vujx538o 528 9 active active JJ cord-274141-vujx538o 528 10 compounds compound NNS cord-274141-vujx538o 528 11 should should MD cord-274141-vujx538o 528 12 be be VB cord-274141-vujx538o 528 13 rigorously rigorously RB cord-274141-vujx538o 528 14 tested test VBN cord-274141-vujx538o 528 15 in in IN cord-274141-vujx538o 528 16 animal animal NN cord-274141-vujx538o 528 17 and and CC cord-274141-vujx538o 528 18 randomized randomized JJ cord-274141-vujx538o 528 19 placebo placebo NN cord-274141-vujx538o 528 20 clinical clinical JJ cord-274141-vujx538o 528 21 trials trial NNS cord-274141-vujx538o 528 22 . . . cord-274141-vujx538o 529 1 Due due IN cord-274141-vujx538o 529 2 to to IN cord-274141-vujx538o 529 3 the the DT cord-274141-vujx538o 529 4 current current JJ cord-274141-vujx538o 529 5 lack lack NN cord-274141-vujx538o 529 6 of of IN cord-274141-vujx538o 529 7 effective effective JJ cord-274141-vujx538o 529 8 and and CC cord-274141-vujx538o 529 9 safe safe JJ cord-274141-vujx538o 529 10 drugs drug NNS cord-274141-vujx538o 529 11 , , , cord-274141-vujx538o 529 12 natural natural JJ cord-274141-vujx538o 529 13 products product NNS cord-274141-vujx538o 529 14 presented present VBN cord-274141-vujx538o 529 15 in in IN cord-274141-vujx538o 529 16 this this DT cord-274141-vujx538o 529 17 review review NN cord-274141-vujx538o 529 18 may may MD cord-274141-vujx538o 529 19 form form VB cord-274141-vujx538o 529 20 part part NN cord-274141-vujx538o 529 21 of of IN cord-274141-vujx538o 529 22 the the DT cord-274141-vujx538o 529 23 health health NN cord-274141-vujx538o 529 24 beliefs belief NNS cord-274141-vujx538o 529 25 , , , cord-274141-vujx538o 529 26 self self NN cord-274141-vujx538o 529 27 - - HYPH cord-274141-vujx538o 529 28 medication medication NN cord-274141-vujx538o 529 29 choices choice NNS cord-274141-vujx538o 529 30 , , , cord-274141-vujx538o 529 31 and and CC cord-274141-vujx538o 529 32 selfefficacy selfefficacy NN cord-274141-vujx538o 529 33 practices practice NNS cord-274141-vujx538o 529 34 that that IN cord-274141-vujx538o 529 35 people people NNS cord-274141-vujx538o 529 36 may may MD cord-274141-vujx538o 529 37 use use VB cord-274141-vujx538o 529 38 to to TO cord-274141-vujx538o 529 39 manage manage VB cord-274141-vujx538o 529 40 COVID-19 COVID-19 NNP cord-274141-vujx538o 529 41 . . . cord-274141-vujx538o 530 1 Natural natural JJ cord-274141-vujx538o 530 2 products product NNS cord-274141-vujx538o 530 3 presented present VBN cord-274141-vujx538o 530 4 in in IN cord-274141-vujx538o 530 5 this this DT cord-274141-vujx538o 530 6 paper paper NN cord-274141-vujx538o 530 7 form form NN cord-274141-vujx538o 530 8 a a DT cord-274141-vujx538o 530 9 repertoire repertoire NN cord-274141-vujx538o 530 10 of of IN cord-274141-vujx538o 530 11 promising promising JJ cord-274141-vujx538o 530 12 leads lead NNS cord-274141-vujx538o 530 13 that that WDT cord-274141-vujx538o 530 14 may may MD cord-274141-vujx538o 530 15 be be VB cord-274141-vujx538o 530 16 repurposed repurpose VBN cord-274141-vujx538o 530 17 into into IN cord-274141-vujx538o 530 18 novel novel JJ cord-274141-vujx538o 530 19 drugs drug NNS cord-274141-vujx538o 530 20 , , , cord-274141-vujx538o 530 21 nutraceuticals nutraceutical NNS cord-274141-vujx538o 530 22 , , , cord-274141-vujx538o 530 23 and and CC cord-274141-vujx538o 530 24 supplements supplement NNS cord-274141-vujx538o 530 25 for for IN cord-274141-vujx538o 530 26 COVID-19 COVID-19 NNP cord-274141-vujx538o 530 27 . . . cord-274141-vujx538o 531 1 If if IN cord-274141-vujx538o 531 2 there there EX cord-274141-vujx538o 531 3 is be VBZ cord-274141-vujx538o 531 4 a a DT cord-274141-vujx538o 531 5 long long JJ cord-274141-vujx538o 531 6 - - HYPH cord-274141-vujx538o 531 7 term term NN cord-274141-vujx538o 531 8 remedy remedy NN cord-274141-vujx538o 531 9 for for IN cord-274141-vujx538o 531 10 COVID-19 COVID-19 NNP cord-274141-vujx538o 531 11 , , , cord-274141-vujx538o 531 12 it -PRON- PRP cord-274141-vujx538o 531 13 must must MD cord-274141-vujx538o 531 14 lie lie VB cord-274141-vujx538o 531 15 in in IN cord-274141-vujx538o 531 16 Mother Mother NNP cord-274141-vujx538o 531 17 Nature Nature NNP cord-274141-vujx538o 531 18 's 's POS cord-274141-vujx538o 531 19 pharmacy pharmacy NN cord-274141-vujx538o 531 20 of of IN cord-274141-vujx538o 531 21 SARS SARS NNP cord-274141-vujx538o 531 22 - - HYPH cord-274141-vujx538o 531 23 CoV-2 CoV-2 NNP cord-274141-vujx538o 531 24 inhibitors inhibitor NNS cord-274141-vujx538o 531 25 and and CC cord-274141-vujx538o 531 26 immunomodulators immunomodulator NNS cord-274141-vujx538o 531 27 from from IN cord-274141-vujx538o 531 28 plants plant NNS cord-274141-vujx538o 531 29 , , , cord-274141-vujx538o 531 30 fungi fungus NNS cord-274141-vujx538o 531 31 , , , cord-274141-vujx538o 531 32 and and CC cord-274141-vujx538o 531 33 marine marine JJ cord-274141-vujx538o 531 34 organisms organism NNS cord-274141-vujx538o 531 35 . . . cord-274141-vujx538o 532 1 Discovery discovery NN cord-274141-vujx538o 532 2 and and CC cord-274141-vujx538o 532 3 development development NN cord-274141-vujx538o 532 4 of of IN cord-274141-vujx538o 532 5 safe safe JJ cord-274141-vujx538o 532 6 - - HYPH cord-274141-vujx538o 532 7 in in IN cord-274141-vujx538o 532 8 - - HYPH cord-274141-vujx538o 532 9 man man NN cord-274141-vujx538o 532 10 broad broad JJ cord-274141-vujx538o 532 11 - - HYPH cord-274141-vujx538o 532 12 spectrum spectrum NN cord-274141-vujx538o 532 13 antiviral antiviral JJ cord-274141-vujx538o 532 14 agents agent NNS cord-274141-vujx538o 532 15 Novel Novel NNP cord-274141-vujx538o 532 16 antiviral antiviral JJ cord-274141-vujx538o 532 17 activities activity NNS cord-274141-vujx538o 532 18 of of IN cord-274141-vujx538o 532 19 obatoclax obatoclax NNP cord-274141-vujx538o 532 20 , , , cord-274141-vujx538o 532 21 emetine emetine NNP cord-274141-vujx538o 532 22 , , , cord-274141-vujx538o 532 23 niclosamide niclosamide NNP cord-274141-vujx538o 532 24 , , , cord-274141-vujx538o 532 25 brequinar brequinar NNP cord-274141-vujx538o 532 26 , , , cord-274141-vujx538o 532 27 and and CC cord-274141-vujx538o 532 28 homoharringtonine homoharringtonine NNP cord-274141-vujx538o 532 29 Al Al NNP cord-274141-vujx538o 532 30 Zarzour Zarzour NNP cord-274141-vujx538o 532 31 R r NN cord-274141-vujx538o 532 32 ( ( -LRB- cord-274141-vujx538o 532 33 2020 2020 CD cord-274141-vujx538o 532 34 ) ) -RRB- cord-274141-vujx538o 533 1 COVID-19 covid-19 VB cord-274141-vujx538o 533 2 and and CC cord-274141-vujx538o 533 3 therapy therapy NN cord-274141-vujx538o 533 4 with with IN cord-274141-vujx538o 533 5 essential essential JJ cord-274141-vujx538o 533 6 oils oil NNS cord-274141-vujx538o 533 7 having have VBG cord-274141-vujx538o 533 8 antiviral antiviral JJ cord-274141-vujx538o 533 9 Glycyrrhizic Glycyrrhizic NNP cord-274141-vujx538o 533 10 acid acid NN cord-274141-vujx538o 533 11 derivatives derivative NNS cord-274141-vujx538o 533 12 as as IN cord-274141-vujx538o 533 13 influenza influenza NN cord-274141-vujx538o 533 14 A A NNP cord-274141-vujx538o 533 15 / / SYM cord-274141-vujx538o 533 16 H1N1 H1N1 NNP cord-274141-vujx538o 533 17 virus virus NN cord-274141-vujx538o 533 18 inhibitors inhibitors VBP cord-274141-vujx538o 533 19 Tea Tea NNP cord-274141-vujx538o 533 20 : : : cord-274141-vujx538o 534 1 a a DT cord-274141-vujx538o 534 2 native native JJ cord-274141-vujx538o 534 3 source source NN cord-274141-vujx538o 534 4 of of IN cord-274141-vujx538o 534 5 antimicrobial antimicrobial JJ cord-274141-vujx538o 534 6 agents agent NNS cord-274141-vujx538o 534 7 Potential potential JJ cord-274141-vujx538o 534 8 of of IN cord-274141-vujx538o 534 9 selected select VBN cord-274141-vujx538o 534 10 Lamiaceae Lamiaceae NNP cord-274141-vujx538o 534 11 plants plant NNS cord-274141-vujx538o 534 12 in in IN cord-274141-vujx538o 534 13 anti anti JJ cord-274141-vujx538o 534 14 ( ( -LRB- cord-274141-vujx538o 534 15 retro retro JJ cord-274141-vujx538o 534 16 ) ) -RRB- cord-274141-vujx538o 534 17 viral viral JJ cord-274141-vujx538o 534 18 therapy therapy NN cord-274141-vujx538o 534 19 Anti anti JJ cord-274141-vujx538o 534 20 - - JJ cord-274141-vujx538o 534 21 human human JJ cord-274141-vujx538o 534 22 coronavirus coronavirus NN cord-274141-vujx538o 534 23 ( ( -LRB- cord-274141-vujx538o 534 24 anti anti JJ cord-274141-vujx538o 534 25 - - JJ cord-274141-vujx538o 534 26 HCoV hcov JJ cord-274141-vujx538o 534 27 ) ) -RRB- cord-274141-vujx538o 534 28 triterpenoids triterpenoid NNS cord-274141-vujx538o 534 29 from from IN cord-274141-vujx538o 534 30 the the DT cord-274141-vujx538o 534 31 leaves leave NNS cord-274141-vujx538o 534 32 of of IN cord-274141-vujx538o 534 33 Euphorbia Euphorbia NNP cord-274141-vujx538o 534 34 neriifolia neriifolia NN cord-274141-vujx538o 534 35 Toona Toona NNP cord-274141-vujx538o 534 36 sinensis sinensis NN cord-274141-vujx538o 534 37 Roem Roem NNP cord-274141-vujx538o 534 38 tender tender NN cord-274141-vujx538o 534 39 leaf leaf NN cord-274141-vujx538o 534 40 extract extract NN cord-274141-vujx538o 534 41 inhibits inhibit VBZ cord-274141-vujx538o 534 42 SARS SARS NNP cord-274141-vujx538o 534 43 coronavirus coronavirus NN cord-274141-vujx538o 534 44 replication replication NN cord-274141-vujx538o 534 45 Inhibition inhibition NN cord-274141-vujx538o 534 46 of of IN cord-274141-vujx538o 534 47 SARS SARS NNP cord-274141-vujx538o 534 48 - - HYPH cord-274141-vujx538o 534 49 CoV CoV NNP cord-274141-vujx538o 534 50 3C 3C NNP cord-274141-vujx538o 534 51 - - HYPH cord-274141-vujx538o 534 52 like like JJ cord-274141-vujx538o 534 53 protease protease NN cord-274141-vujx538o 534 54 activity activity NN cord-274141-vujx538o 534 55 by by IN cord-274141-vujx538o 534 56 theaflavin-3,3′-digallate theaflavin-3,3′-digallate NNP cord-274141-vujx538o 535 1 ( ( -LRB- cord-274141-vujx538o 535 2 TF3 TF3 NNP cord-274141-vujx538o 535 3 ) ) -RRB- cord-274141-vujx538o 535 4 . . . cord-274141-vujx538o 536 1 Evid Evid NNP cord-274141-vujx538o 536 2 Based base VBN cord-274141-vujx538o 537 1 In in IN cord-274141-vujx538o 537 2 vitro vitro FW cord-274141-vujx538o 537 3 susceptibility susceptibility NN cord-274141-vujx538o 537 4 of of IN cord-274141-vujx538o 537 5 10 10 CD cord-274141-vujx538o 537 6 clinical clinical JJ cord-274141-vujx538o 537 7 isolates isolate NNS cord-274141-vujx538o 537 8 of of IN cord-274141-vujx538o 537 9 SARS SARS NNP cord-274141-vujx538o 537 10 coronavirus coronavirus NN cord-274141-vujx538o 537 11 to to IN cord-274141-vujx538o 537 12 selected select VBN cord-274141-vujx538o 537 13 antiviral antiviral JJ cord-274141-vujx538o 537 14 compounds compound NNS cord-274141-vujx538o 538 1 Binding bind VBG cord-274141-vujx538o 538 2 interaction interaction NN cord-274141-vujx538o 538 3 of of IN cord-274141-vujx538o 538 4 quercetin-3-βgalactoside quercetin-3-βgalactoside NN cord-274141-vujx538o 538 5 and and CC cord-274141-vujx538o 538 6 its -PRON- PRP$ cord-274141-vujx538o 538 7 synthetic synthetic JJ cord-274141-vujx538o 538 8 derivatives derivative NNS cord-274141-vujx538o 538 9 with with IN cord-274141-vujx538o 538 10 SARS SARS NNP cord-274141-vujx538o 538 11 - - HYPH cord-274141-vujx538o 538 12 CoV CoV NNP cord-274141-vujx538o 538 13 3CL 3CL NNP cord-274141-vujx538o 538 14 pro pro JJ cord-274141-vujx538o 538 15 : : : cord-274141-vujx538o 538 16 structure structure NN cord-274141-vujx538o 538 17 - - HYPH cord-274141-vujx538o 538 18 activity activity NN cord-274141-vujx538o 538 19 relationship relationship NN cord-274141-vujx538o 538 20 studies study NNS cord-274141-vujx538o 538 21 reveal reveal VBP cord-274141-vujx538o 538 22 salient salient JJ cord-274141-vujx538o 538 23 pharmacophore pharmacophore NN cord-274141-vujx538o 538 24 features feature VBZ cord-274141-vujx538o 538 25 A a DT cord-274141-vujx538o 538 26 report report NN cord-274141-vujx538o 538 27 of of IN cord-274141-vujx538o 538 28 clinical clinical JJ cord-274141-vujx538o 538 29 diagnosis diagnosis NN cord-274141-vujx538o 538 30 and and CC cord-274141-vujx538o 538 31 treatment treatment NN cord-274141-vujx538o 538 32 of of IN cord-274141-vujx538o 538 33 nine nine CD cord-274141-vujx538o 538 34 cases case NNS cord-274141-vujx538o 538 35 of of IN cord-274141-vujx538o 538 36 coronavirus coronavirus NN cord-274141-vujx538o 538 37 disease disease NN cord-274141-vujx538o 538 38 2019 2019 CD cord-274141-vujx538o 538 39 Statistical statistical JJ cord-274141-vujx538o 538 40 evidence evidence NN cord-274141-vujx538o 538 41 for for IN cord-274141-vujx538o 538 42 the the DT cord-274141-vujx538o 538 43 usefulness usefulness NN cord-274141-vujx538o 538 44 of of IN cord-274141-vujx538o 538 45 Chinese chinese JJ cord-274141-vujx538o 538 46 medicine medicine NN cord-274141-vujx538o 538 47 in in IN cord-274141-vujx538o 538 48 the the DT cord-274141-vujx538o 538 49 treatment treatment NN cord-274141-vujx538o 538 50 of of IN cord-274141-vujx538o 538 51 SARS SARS NNP cord-274141-vujx538o 538 52 Antiviral Antiviral NNP cord-274141-vujx538o 538 53 effects effect NNS cord-274141-vujx538o 538 54 of of IN cord-274141-vujx538o 538 55 saikosaponins saikosaponin NNS cord-274141-vujx538o 538 56 on on IN cord-274141-vujx538o 538 57 human human JJ cord-274141-vujx538o 538 58 coronavirus coronavirus NN cord-274141-vujx538o 538 59 229E 229e CD cord-274141-vujx538o 538 60 in in IN cord-274141-vujx538o 538 61 vitro vitro FW cord-274141-vujx538o 538 62 Plants plant NNS cord-274141-vujx538o 538 63 as as IN cord-274141-vujx538o 538 64 antimalarial antimalarial JJ cord-274141-vujx538o 538 65 agents agent NNS cord-274141-vujx538o 538 66 in in IN cord-274141-vujx538o 538 67 Sub Sub NNP cord-274141-vujx538o 538 68 - - HYPH cord-274141-vujx538o 538 69 Saharan Saharan NNP cord-274141-vujx538o 538 70 Africa Africa NNP cord-274141-vujx538o 538 71 Green Green NNP cord-274141-vujx538o 538 72 Medicines Medicines NNPS cord-274141-vujx538o 538 73 : : : cord-274141-vujx538o 538 74 pharmacy pharmacy NN cord-274141-vujx538o 538 75 of of IN cord-274141-vujx538o 538 76 natural natural JJ cord-274141-vujx538o 538 77 products product NNS cord-274141-vujx538o 538 78 for for IN cord-274141-vujx538o 538 79 HIV HIV NNP cord-274141-vujx538o 538 80 and and CC cord-274141-vujx538o 538 81 five five CD cord-274141-vujx538o 538 82 AIDS AIDS NNP cord-274141-vujx538o 538 83 - - HYPH cord-274141-vujx538o 538 84 related relate VBN cord-274141-vujx538o 538 85 infections infection NNS cord-274141-vujx538o 538 86 Chemical chemical JJ cord-274141-vujx538o 538 87 diversity diversity NN cord-274141-vujx538o 538 88 and and CC cord-274141-vujx538o 538 89 activity activity NN cord-274141-vujx538o 538 90 profiles profile NNS cord-274141-vujx538o 538 91 of of IN cord-274141-vujx538o 538 92 HIV-1 HIV-1 NNP cord-274141-vujx538o 538 93 reverse reverse VBP cord-274141-vujx538o 538 94 transcriptase transcriptase NN cord-274141-vujx538o 538 95 inhibitors inhibitor NNS cord-274141-vujx538o 538 96 from from IN cord-274141-vujx538o 538 97 plants plant NNS cord-274141-vujx538o 538 98 Evaluation Evaluation NNP cord-274141-vujx538o 538 99 of of IN cord-274141-vujx538o 538 100 antiviral antiviral JJ cord-274141-vujx538o 538 101 activities activity NNS cord-274141-vujx538o 538 102 of of IN cord-274141-vujx538o 538 103 Houttuynia Houttuynia NNP cord-274141-vujx538o 538 104 cordata cordata NN cord-274141-vujx538o 538 105 Thunb Thunb NNP cord-274141-vujx538o 538 106 . . . cord-274141-vujx538o 539 1 extract extract VB cord-274141-vujx538o 539 2 , , , cord-274141-vujx538o 539 3 quercetin quercetin NN cord-274141-vujx538o 539 4 , , , cord-274141-vujx538o 539 5 quercetrin quercetrin NNP cord-274141-vujx538o 539 6 and and CC cord-274141-vujx538o 539 7 cinanserin cinanserin NNP cord-274141-vujx538o 539 8 on on IN cord-274141-vujx538o 539 9 murine murine JJ cord-274141-vujx538o 539 10 coronavirus coronavirus NN cord-274141-vujx538o 539 11 and and CC cord-274141-vujx538o 539 12 dengue dengue NN cord-274141-vujx538o 539 13 virus virus NN cord-274141-vujx538o 539 14 infection infection NN cord-274141-vujx538o 539 15 Geranylated geranylate VBD cord-274141-vujx538o 539 16 flavonoids flavonoid NNS cord-274141-vujx538o 539 17 displaying display VBG cord-274141-vujx538o 539 18 SARS SARS NNP cord-274141-vujx538o 539 19 - - HYPH cord-274141-vujx538o 539 20 CoV CoV NNP cord-274141-vujx538o 539 21 papain papain NN cord-274141-vujx538o 539 22 - - HYPH cord-274141-vujx538o 539 23 like like JJ cord-274141-vujx538o 539 24 protease protease NN cord-274141-vujx538o 539 25 inhibition inhibition NN cord-274141-vujx538o 539 26 from from IN cord-274141-vujx538o 539 27 the the DT cord-274141-vujx538o 539 28 fruits fruit NNS cord-274141-vujx538o 539 29 of of IN cord-274141-vujx538o 539 30 Paulownia Paulownia NNP cord-274141-vujx538o 539 31 tomentosa tomentosa VBN cord-274141-vujx538o 539 32 Antiviral antiviral JJ cord-274141-vujx538o 539 33 activity activity NN cord-274141-vujx538o 539 34 of of IN cord-274141-vujx538o 539 35 quercetin quercetin NN cord-274141-vujx538o 539 36 7-rhamnoside 7-rhamnoside CD cord-274141-vujx538o 539 37 against against IN cord-274141-vujx538o 539 38 porcine porcine JJ cord-274141-vujx538o 539 39 epidemic epidemic NN cord-274141-vujx538o 539 40 diarrhea diarrhea NN cord-274141-vujx538o 539 41 virus virus NN cord-274141-vujx538o 539 42 Remdesivir Remdesivir NNP cord-274141-vujx538o 539 43 , , , cord-274141-vujx538o 539 44 lopinavir lopinavir NNS cord-274141-vujx538o 539 45 , , , cord-274141-vujx538o 539 46 emetine emetine NNP cord-274141-vujx538o 539 47 , , , cord-274141-vujx538o 539 48 and and CC cord-274141-vujx538o 539 49 homoharringtonine homoharringtonine NN cord-274141-vujx538o 539 50 inhibit inhibit VB cord-274141-vujx538o 539 51 SARS SARS NNP cord-274141-vujx538o 539 52 - - HYPH cord-274141-vujx538o 539 53 CoV-2 CoV-2 NNP cord-274141-vujx538o 539 54 replication replication NN cord-274141-vujx538o 539 55 in in IN cord-274141-vujx538o 539 56 vitro vitro FW cord-274141-vujx538o 539 57 Glycyrrhizin Glycyrrhizin NNP cord-274141-vujx538o 539 58 , , , cord-274141-vujx538o 539 59 an an DT cord-274141-vujx538o 539 60 active active JJ cord-274141-vujx538o 539 61 component component NN cord-274141-vujx538o 539 62 of of IN cord-274141-vujx538o 539 63 liquorice liquorice NN cord-274141-vujx538o 539 64 roots root NNS cord-274141-vujx538o 539 65 , , , cord-274141-vujx538o 539 66 and and CC cord-274141-vujx538o 539 67 replication replication NN cord-274141-vujx538o 539 68 of of IN cord-274141-vujx538o 539 69 SARS SARS NNP cord-274141-vujx538o 539 70 - - HYPH cord-274141-vujx538o 539 71 associated associate VBN cord-274141-vujx538o 539 72 coronavirus coronavirus NN cord-274141-vujx538o 539 73 Inhibitors Inhibitors NNP cord-274141-vujx538o 539 74 of of IN cord-274141-vujx538o 539 75 osteoclast osteoclast JJ cord-274141-vujx538o 539 76 formation formation NN cord-274141-vujx538o 539 77 from from IN cord-274141-vujx538o 539 78 rhizomes rhizome NNS cord-274141-vujx538o 539 79 of of IN cord-274141-vujx538o 539 80 Cibotium Cibotium NNP cord-274141-vujx538o 539 81 barometz barometz NN cord-274141-vujx538o 540 1 Recent recent JJ cord-274141-vujx538o 540 2 highlights highlight NNS cord-274141-vujx538o 540 3 in in IN cord-274141-vujx538o 540 4 the the DT cord-274141-vujx538o 540 5 development development NN cord-274141-vujx538o 540 6 of of IN cord-274141-vujx538o 540 7 new new JJ cord-274141-vujx538o 540 8 antiviral antiviral JJ cord-274141-vujx538o 540 9 drugs drug NNS cord-274141-vujx538o 540 10 Screening screen VBG cord-274141-vujx538o 540 11 of of IN cord-274141-vujx538o 540 12 an an DT cord-274141-vujx538o 540 13 FDA FDA NNP cord-274141-vujx538o 540 14 - - HYPH cord-274141-vujx538o 540 15 approved approve VBN cord-274141-vujx538o 540 16 compound compound NN cord-274141-vujx538o 540 17 library library NN cord-274141-vujx538o 540 18 identifies identify VBZ cord-274141-vujx538o 540 19 four four CD cord-274141-vujx538o 540 20 small small JJ cord-274141-vujx538o 540 21 - - HYPH cord-274141-vujx538o 540 22 molecule molecule NN cord-274141-vujx538o 540 23 inhibitors inhibitor NNS cord-274141-vujx538o 540 24 of of IN cord-274141-vujx538o 540 25 Middle Middle NNP cord-274141-vujx538o 540 26 East East NNP cord-274141-vujx538o 540 27 respiratory respiratory JJ cord-274141-vujx538o 540 28 syndrome syndrome NN cord-274141-vujx538o 540 29 coronavirus coronavirus NN cord-274141-vujx538o 540 30 replication replication NN cord-274141-vujx538o 540 31 in in IN cord-274141-vujx538o 540 32 cell cell NN cord-274141-vujx538o 540 33 culture culture NN cord-274141-vujx538o 541 1 The the DT cord-274141-vujx538o 541 2 natural natural JJ cord-274141-vujx538o 541 3 compound compound NN cord-274141-vujx538o 541 4 homoharringtonine homoharringtonine NN cord-274141-vujx538o 541 5 presents present VBZ cord-274141-vujx538o 541 6 broad broad JJ cord-274141-vujx538o 541 7 antiviral antiviral JJ cord-274141-vujx538o 541 8 activity activity NN cord-274141-vujx538o 541 9 in in IN cord-274141-vujx538o 541 10 vitro vitro FW cord-274141-vujx538o 541 11 and and CC cord-274141-vujx538o 541 12 in in IN cord-274141-vujx538o 541 13 vivo vivo NNP cord-274141-vujx538o 541 14 Emodin Emodin NNP cord-274141-vujx538o 541 15 : : : cord-274141-vujx538o 541 16 a a DT cord-274141-vujx538o 541 17 review review NN cord-274141-vujx538o 541 18 of of IN cord-274141-vujx538o 541 19 its -PRON- PRP$ cord-274141-vujx538o 541 20 pharmacology pharmacology NN cord-274141-vujx538o 541 21 , , , cord-274141-vujx538o 541 22 toxicity toxicity NN cord-274141-vujx538o 541 23 and and CC cord-274141-vujx538o 541 24 pharmacokinetics pharmacokinetic NNS cord-274141-vujx538o 541 25 Natural natural JJ cord-274141-vujx538o 541 26 products product NNS cord-274141-vujx538o 541 27 as as IN cord-274141-vujx538o 541 28 antiviral antiviral JJ cord-274141-vujx538o 541 29 agents agent NNS cord-274141-vujx538o 541 30 Anti Anti NNP cord-274141-vujx538o 541 31 - - NNP cord-274141-vujx538o 541 32 HCV HCV NNP cord-274141-vujx538o 541 33 , , , cord-274141-vujx538o 541 34 nucleotide nucleotide JJ cord-274141-vujx538o 541 35 inhibitors inhibitor NNS cord-274141-vujx538o 541 36 , , , cord-274141-vujx538o 541 37 repurposing repurpose VBG cord-274141-vujx538o 541 38 against against IN cord-274141-vujx538o 541 39 COVID-19 COVID-19 NNP cord-274141-vujx538o 541 40 Neutralizing neutralize VBG cord-274141-vujx538o 541 41 activity activity NN cord-274141-vujx538o 541 42 of of IN cord-274141-vujx538o 541 43 Echinacea Echinacea NNP cord-274141-vujx538o 541 44 purpurea purpurea NN cord-274141-vujx538o 541 45 on on IN cord-274141-vujx538o 541 46 coronaviruses coronaviruse NNS cord-274141-vujx538o 541 47 including include VBG cord-274141-vujx538o 541 48 highly highly RB cord-274141-vujx538o 541 49 pathogenic pathogenic JJ cord-274141-vujx538o 542 1 Middle middle JJ cord-274141-vujx538o 542 2 - - HYPH cord-274141-vujx538o 542 3 East East NNP cord-274141-vujx538o 542 4 - - HYPH cord-274141-vujx538o 542 5 Respiratory Respiratory NNP cord-274141-vujx538o 542 6 Syndrome Syndrome NNP cord-274141-vujx538o 542 7 Virus virus NN cord-274141-vujx538o 542 8 ( ( -LRB- cord-274141-vujx538o 542 9 MERS MERS NNP cord-274141-vujx538o 542 10 - - HYPH cord-274141-vujx538o 542 11 CoV CoV NNP cord-274141-vujx538o 542 12 ) ) -RRB- cord-274141-vujx538o 543 1 Andrographolide Andrographolide NNP cord-274141-vujx538o 543 2 as as IN cord-274141-vujx538o 543 3 a a DT cord-274141-vujx538o 543 4 potential potential JJ cord-274141-vujx538o 543 5 inhibitor inhibitor NN cord-274141-vujx538o 543 6 of of IN cord-274141-vujx538o 543 7 SARS SARS NNP cord-274141-vujx538o 543 8 - - HYPH cord-274141-vujx538o 543 9 CoV-2 CoV-2 NNP cord-274141-vujx538o 543 10 main main JJ cord-274141-vujx538o 543 11 protease protease NN cord-274141-vujx538o 543 12 : : : cord-274141-vujx538o 543 13 an an DT cord-274141-vujx538o 543 14 in in IN cord-274141-vujx538o 543 15 silico silico NN cord-274141-vujx538o 543 16 approach approach NN cord-274141-vujx538o 543 17 Systematic systematic JJ cord-274141-vujx538o 543 18 review review NN cord-274141-vujx538o 543 19 of of IN cord-274141-vujx538o 543 20 the the DT cord-274141-vujx538o 543 21 efficacy efficacy NN cord-274141-vujx538o 543 22 and and CC cord-274141-vujx538o 543 23 safety safety NN cord-274141-vujx538o 543 24 of of IN cord-274141-vujx538o 543 25 antiretroviral antiretroviral JJ cord-274141-vujx538o 543 26 drugs drug NNS cord-274141-vujx538o 543 27 against against IN cord-274141-vujx538o 543 28 SARS SARS NNP cord-274141-vujx538o 543 29 , , , cord-274141-vujx538o 543 30 MERS MERS NNP cord-274141-vujx538o 543 31 , , , cord-274141-vujx538o 543 32 or or CC cord-274141-vujx538o 543 33 COVID-19 COVID-19 NNP cord-274141-vujx538o 543 34 : : : cord-274141-vujx538o 543 35 initial initial JJ cord-274141-vujx538o 543 36 assessment assessment NN cord-274141-vujx538o 544 1 Molecular molecular JJ cord-274141-vujx538o 544 2 evolution evolution NN cord-274141-vujx538o 544 3 of of IN cord-274141-vujx538o 544 4 human human JJ cord-274141-vujx538o 544 5 coronavirus coronavirus NN cord-274141-vujx538o 544 6 genomes genome NNS cord-274141-vujx538o 544 7 Marine marine JJ cord-274141-vujx538o 544 8 metabolites metabolite NNS cord-274141-vujx538o 544 9 : : : cord-274141-vujx538o 544 10 oceans ocean NNS cord-274141-vujx538o 544 11 of of IN cord-274141-vujx538o 544 12 opportunity opportunity NN cord-274141-vujx538o 544 13 Evidence evidence NN cord-274141-vujx538o 544 14 that that IN cord-274141-vujx538o 544 15 vitamin vitamin NN cord-274141-vujx538o 544 16 D d NN cord-274141-vujx538o 544 17 supplementation supplementation NN cord-274141-vujx538o 544 18 could could MD cord-274141-vujx538o 544 19 reduce reduce VB cord-274141-vujx538o 544 20 risk risk NN cord-274141-vujx538o 544 21 of of IN cord-274141-vujx538o 544 22 influenza influenza NN cord-274141-vujx538o 544 23 and and CC cord-274141-vujx538o 544 24 COVID-19 covid-19 JJ cord-274141-vujx538o 544 25 infections infection NNS cord-274141-vujx538o 544 26 and and CC cord-274141-vujx538o 544 27 deaths death NNS cord-274141-vujx538o 544 28 Antiviral antiviral JJ cord-274141-vujx538o 544 29 marine marine JJ cord-274141-vujx538o 544 30 natural natural JJ cord-274141-vujx538o 544 31 products product NNS cord-274141-vujx538o 545 1 Quercetin quercetin JJ cord-274141-vujx538o 545 2 supplementation supplementation NN cord-274141-vujx538o 545 3 and and CC cord-274141-vujx538o 545 4 upper upper JJ cord-274141-vujx538o 545 5 respiratory respiratory JJ cord-274141-vujx538o 545 6 tract tract NN cord-274141-vujx538o 545 7 infection infection NN cord-274141-vujx538o 545 8 : : : cord-274141-vujx538o 545 9 a a DT cord-274141-vujx538o 545 10 randomized randomized JJ cord-274141-vujx538o 545 11 community community NN cord-274141-vujx538o 545 12 clinical clinical JJ cord-274141-vujx538o 545 13 trial trial NN cord-274141-vujx538o 545 14 Emodin Emodin NNP cord-274141-vujx538o 545 15 blocks block VBZ cord-274141-vujx538o 545 16 the the DT cord-274141-vujx538o 545 17 SARS SARS NNP cord-274141-vujx538o 545 18 coronavirus coronavirus NN cord-274141-vujx538o 545 19 spike spike NN cord-274141-vujx538o 545 20 protein protein NN cord-274141-vujx538o 545 21 and and CC cord-274141-vujx538o 545 22 angiotensin angiotensin NN cord-274141-vujx538o 545 23 - - HYPH cord-274141-vujx538o 545 24 converting convert VBG cord-274141-vujx538o 545 25 enzyme enzyme NN cord-274141-vujx538o 545 26 2 2 CD cord-274141-vujx538o 545 27 interaction interaction NN cord-274141-vujx538o 545 28 2-Substituted 2-substituted CD cord-274141-vujx538o 545 29 benzoxazinone benzoxazinone CD cord-274141-vujx538o 545 30 analogues analogue NNS cord-274141-vujx538o 545 31 as as IN cord-274141-vujx538o 545 32 antihuman antihuman JJ cord-274141-vujx538o 545 33 coronavirus coronavirus NN cord-274141-vujx538o 545 34 ( ( -LRB- cord-274141-vujx538o 545 35 anti anti JJ cord-274141-vujx538o 545 36 - - JJ cord-274141-vujx538o 545 37 HCoV hcov JJ cord-274141-vujx538o 545 38 ) ) -RRB- cord-274141-vujx538o 545 39 and and CC cord-274141-vujx538o 545 40 ICAM-1 icam-1 JJ cord-274141-vujx538o 545 41 expression expression NN cord-274141-vujx538o 545 42 inhibition inhibition NN cord-274141-vujx538o 545 43 agents agent NNS cord-274141-vujx538o 546 1 Can Can MD cord-274141-vujx538o 546 2 herbal herbal JJ cord-274141-vujx538o 546 3 medicine medicine NN cord-274141-vujx538o 546 4 assist assist VB cord-274141-vujx538o 546 5 against against IN cord-274141-vujx538o 546 6 avian avian JJ cord-274141-vujx538o 546 7 flu flu NN cord-274141-vujx538o 546 8 ? ? . cord-274141-vujx538o 547 1 Learning learn VBG cord-274141-vujx538o 547 2 from from IN cord-274141-vujx538o 547 3 the the DT cord-274141-vujx538o 547 4 experience experience NN cord-274141-vujx538o 547 5 of of IN cord-274141-vujx538o 547 6 using use VBG cord-274141-vujx538o 547 7 supplementary supplementary JJ cord-274141-vujx538o 547 8 treatment treatment NN cord-274141-vujx538o 547 9 with with IN cord-274141-vujx538o 547 10 Chinese chinese JJ cord-274141-vujx538o 547 11 medicine medicine NN cord-274141-vujx538o 547 12 on on IN cord-274141-vujx538o 547 13 SARS SARS NNP cord-274141-vujx538o 547 14 or or CC cord-274141-vujx538o 547 15 SARS SARS NNP cord-274141-vujx538o 547 16 - - HYPH cord-274141-vujx538o 547 17 like like JJ cord-274141-vujx538o 547 18 infectious infectious JJ cord-274141-vujx538o 547 19 disease disease NN cord-274141-vujx538o 547 20 in in IN cord-274141-vujx538o 547 21 2003 2003 CD cord-274141-vujx538o 548 1 The the DT cord-274141-vujx538o 548 2 lesson lesson NN cord-274141-vujx538o 548 3 of of IN cord-274141-vujx538o 548 4 supplementary supplementary JJ cord-274141-vujx538o 548 5 treatment treatment NN cord-274141-vujx538o 548 6 with with IN cord-274141-vujx538o 548 7 Chinese chinese JJ cord-274141-vujx538o 548 8 medicine medicine NN cord-274141-vujx538o 548 9 on on IN cord-274141-vujx538o 548 10 severe severe JJ cord-274141-vujx538o 548 11 laboratory laboratory NN cord-274141-vujx538o 548 12 - - HYPH cord-274141-vujx538o 548 13 confirmed confirm VBN cord-274141-vujx538o 548 14 SARS SARS NNP cord-274141-vujx538o 548 15 patients patient NNS cord-274141-vujx538o 548 16 SARS SARS NNP cord-274141-vujx538o 548 17 coronavirus coronavirus NN cord-274141-vujx538o 548 18 , , , cord-274141-vujx538o 548 19 but but CC cord-274141-vujx538o 548 20 not not RB cord-274141-vujx538o 548 21 human human JJ cord-274141-vujx538o 548 22 coronavirus coronavirus NN cord-274141-vujx538o 549 1 NL63 NL63 NNP cord-274141-vujx538o 549 2 , , , cord-274141-vujx538o 549 3 utilizes utilize VBZ cord-274141-vujx538o 549 4 cathepsin cathepsin NN cord-274141-vujx538o 549 5 L l NN cord-274141-vujx538o 549 6 to to TO cord-274141-vujx538o 549 7 infect infect VB cord-274141-vujx538o 549 8 ACE2-expressing ace2-expressing NN cord-274141-vujx538o 549 9 cells cell NNS cord-274141-vujx538o 549 10 Applications application NNS cord-274141-vujx538o 549 11 of of IN cord-274141-vujx538o 549 12 the the DT cord-274141-vujx538o 549 13 phytomedicine phytomedicine NN cord-274141-vujx538o 549 14 Echinacea Echinacea NNP cord-274141-vujx538o 549 15 purpurea purpurea NN cord-274141-vujx538o 549 16 ( ( -LRB- cord-274141-vujx538o 549 17 purple purple JJ cord-274141-vujx538o 549 18 coneflower coneflower NNP cord-274141-vujx538o 549 19 ) ) -RRB- cord-274141-vujx538o 549 20 in in IN cord-274141-vujx538o 549 21 infectious infectious JJ cord-274141-vujx538o 549 22 diseases disease NNS cord-274141-vujx538o 549 23 Inhibitory inhibitory JJ cord-274141-vujx538o 549 24 activities activity NNS cord-274141-vujx538o 549 25 of of IN cord-274141-vujx538o 549 26 Cassia Cassia NNP cord-274141-vujx538o 549 27 tora tora NNP cord-274141-vujx538o 549 28 and and CC cord-274141-vujx538o 549 29 its -PRON- PRP$ cord-274141-vujx538o 549 30 anthraquinone anthraquinone NN cord-274141-vujx538o 549 31 constituents constituent NNS cord-274141-vujx538o 549 32 on on IN cord-274141-vujx538o 549 33 angiotensin angiotensin NN cord-274141-vujx538o 549 34 - - HYPH cord-274141-vujx538o 549 35 converting convert VBG cord-274141-vujx538o 549 36 enzyme enzyme NN cord-274141-vujx538o 549 37 Ginseng Ginseng NNP cord-274141-vujx538o 549 38 , , , cord-274141-vujx538o 549 39 the the DT cord-274141-vujx538o 549 40 natural natural JJ cord-274141-vujx538o 549 41 effectual effectual JJ cord-274141-vujx538o 549 42 antiviral antiviral JJ cord-274141-vujx538o 549 43 : : : cord-274141-vujx538o 549 44 protective protective JJ cord-274141-vujx538o 549 45 effects effect NNS cord-274141-vujx538o 549 46 of of IN cord-274141-vujx538o 549 47 Korean korean JJ cord-274141-vujx538o 549 48 red red JJ cord-274141-vujx538o 549 49 ginseng ginseng NN cord-274141-vujx538o 549 50 against against IN cord-274141-vujx538o 549 51 viral viral JJ cord-274141-vujx538o 549 52 infection infection NN cord-274141-vujx538o 549 53 Natural natural JJ cord-274141-vujx538o 549 54 products product NNS cord-274141-vujx538o 549 55 and and CC cord-274141-vujx538o 549 56 their -PRON- PRP$ cord-274141-vujx538o 549 57 derivatives derivative NNS cord-274141-vujx538o 549 58 against against IN cord-274141-vujx538o 549 59 coronavirus coronavirus NN cord-274141-vujx538o 549 60 : : : cord-274141-vujx538o 549 61 a a DT cord-274141-vujx538o 549 62 review review NN cord-274141-vujx538o 549 63 of of IN cord-274141-vujx538o 549 64 the the DT cord-274141-vujx538o 549 65 non non JJ cord-274141-vujx538o 549 66 - - JJ cord-274141-vujx538o 549 67 clinical clinical JJ cord-274141-vujx538o 549 68 and and CC cord-274141-vujx538o 549 69 pre pre JJ cord-274141-vujx538o 549 70 - - JJ cord-274141-vujx538o 549 71 clinical clinical JJ cord-274141-vujx538o 549 72 data datum NNS cord-274141-vujx538o 549 73 cytotoxicity cytotoxicity NN cord-274141-vujx538o 549 74 and and CC cord-274141-vujx538o 549 75 active active JJ cord-274141-vujx538o 549 76 compound compound NN cord-274141-vujx538o 549 77 of of IN cord-274141-vujx538o 549 78 Pechuel Pechuel NNP cord-274141-vujx538o 549 79 - - HYPH cord-274141-vujx538o 549 80 loeschea loeschea NNP cord-274141-vujx538o 549 81 leubnitziae leubnitziae NNP cord-274141-vujx538o 549 82 O. O. NNP cord-274141-vujx538o 549 83 Hoffm Hoffm NNP cord-274141-vujx538o 549 84 . . . cord-274141-vujx538o 550 1 ( ( -LRB- cord-274141-vujx538o 550 2 Asteraceae Asteraceae NNP cord-274141-vujx538o 550 3 ) ) -RRB- cord-274141-vujx538o 550 4 of of IN cord-274141-vujx538o 550 5 Namibia Namibia NNP cord-274141-vujx538o 550 6 Development Development NNP cord-274141-vujx538o 550 7 of of IN cord-274141-vujx538o 550 8 chemical chemical JJ cord-274141-vujx538o 550 9 inhibitors inhibitor NNS cord-274141-vujx538o 550 10 of of IN cord-274141-vujx538o 550 11 the the DT cord-274141-vujx538o 550 12 SARS SARS NNP cord-274141-vujx538o 550 13 coronavirus coronavirus NN cord-274141-vujx538o 550 14 : : : cord-274141-vujx538o 550 15 viral viral JJ cord-274141-vujx538o 550 16 helicase helicase NN cord-274141-vujx538o 550 17 as as IN cord-274141-vujx538o 550 18 a a DT cord-274141-vujx538o 550 19 potential potential JJ cord-274141-vujx538o 550 20 target target NN cord-274141-vujx538o 550 21 Plant plant NN cord-274141-vujx538o 550 22 lectins lectin NNS cord-274141-vujx538o 550 23 are be VBP cord-274141-vujx538o 550 24 potent potent JJ cord-274141-vujx538o 550 25 inhibitors inhibitor NNS cord-274141-vujx538o 550 26 of of IN cord-274141-vujx538o 550 27 coronaviruses coronaviruse NNS cord-274141-vujx538o 550 28 by by IN cord-274141-vujx538o 550 29 interfering interfere VBG cord-274141-vujx538o 550 30 with with IN cord-274141-vujx538o 550 31 two two CD cord-274141-vujx538o 550 32 targets target NNS cord-274141-vujx538o 550 33 in in IN cord-274141-vujx538o 550 34 the the DT cord-274141-vujx538o 550 35 viral viral JJ cord-274141-vujx538o 550 36 replication replication NN cord-274141-vujx538o 550 37 cycle cycle NN cord-274141-vujx538o 550 38 Natural Natural NNP cord-274141-vujx538o 550 39 bis bis NNP cord-274141-vujx538o 550 40 - - HYPH cord-274141-vujx538o 550 41 benzylisoquinoline benzylisoquinoline JJ cord-274141-vujx538o 550 42 alkaloids alkaloid NNS cord-274141-vujx538o 550 43 - - HYPH cord-274141-vujx538o 550 44 tetrandrine tetrandrine NN cord-274141-vujx538o 550 45 , , , cord-274141-vujx538o 550 46 fangchinoline fangchinoline NN cord-274141-vujx538o 550 47 , , , cord-274141-vujx538o 550 48 and and CC cord-274141-vujx538o 550 49 cepharanthine cepharanthine NN cord-274141-vujx538o 550 50 , , , cord-274141-vujx538o 550 51 inhibit inhibit VBP cord-274141-vujx538o 550 52 human human JJ cord-274141-vujx538o 550 53 coronavirus coronavirus NN cord-274141-vujx538o 550 54 OC43 OC43 NNP cord-274141-vujx538o 550 55 infection infection NN cord-274141-vujx538o 550 56 of of IN cord-274141-vujx538o 550 57 MRC-5 MRC-5 NNP cord-274141-vujx538o 550 58 human human JJ cord-274141-vujx538o 550 59 lung lung NN cord-274141-vujx538o 550 60 cells cell NNS cord-274141-vujx538o 550 61 Medicinal medicinal JJ cord-274141-vujx538o 550 62 herbal herbal JJ cord-274141-vujx538o 550 63 extracts extract NNS cord-274141-vujx538o 550 64 of of IN cord-274141-vujx538o 550 65 Sophorae Sophorae NNP cord-274141-vujx538o 550 66 radix radix NN cord-274141-vujx538o 550 67 , , , cord-274141-vujx538o 550 68 Acanthopanacis Acanthopanacis NNP cord-274141-vujx538o 550 69 cortex cortex NN cord-274141-vujx538o 550 70 , , , cord-274141-vujx538o 550 71 Sanguisorbae Sanguisorbae NNP cord-274141-vujx538o 550 72 radix radix NN cord-274141-vujx538o 550 73 and and CC cord-274141-vujx538o 550 74 Torilis Torilis NNP cord-274141-vujx538o 550 75 fructus fructus NNP cord-274141-vujx538o 551 1 inhibit inhibit VB cord-274141-vujx538o 551 2 coronavirus coronavirus NN cord-274141-vujx538o 551 3 replication replication NN cord-274141-vujx538o 552 1 in in IN cord-274141-vujx538o 552 2 vitro vitro FW cord-274141-vujx538o 553 1 In in IN cord-274141-vujx538o 553 2 vitro vitro FW cord-274141-vujx538o 553 3 inhibition inhibition NN cord-274141-vujx538o 553 4 of of IN cord-274141-vujx538o 553 5 coronavirus coronavirus NN cord-274141-vujx538o 553 6 replications replication NNS cord-274141-vujx538o 553 7 by by IN cord-274141-vujx538o 553 8 the the DT cord-274141-vujx538o 553 9 traditionally traditionally RB cord-274141-vujx538o 553 10 used use VBN cord-274141-vujx538o 553 11 medicinal medicinal JJ cord-274141-vujx538o 553 12 herbal herbal JJ cord-274141-vujx538o 553 13 extracts extract NNS cord-274141-vujx538o 553 14 , , , cord-274141-vujx538o 553 15 Cimicifuga Cimicifuga NNP cord-274141-vujx538o 553 16 rhizoma rhizoma NN cord-274141-vujx538o 553 17 , , , cord-274141-vujx538o 553 18 Meliae Meliae NNP cord-274141-vujx538o 553 19 cortex cortex NN cord-274141-vujx538o 553 20 , , , cord-274141-vujx538o 553 21 Coptidis Coptidis NNP cord-274141-vujx538o 553 22 rhizoma rhizoma NN cord-274141-vujx538o 553 23 , , , cord-274141-vujx538o 553 24 and and CC cord-274141-vujx538o 553 25 Phellodendron Phellodendron NNP cord-274141-vujx538o 553 26 cortex cortex NN cord-274141-vujx538o 553 27 Antiviral antiviral JJ cord-274141-vujx538o 553 28 escin escin VBZ cord-274141-vujx538o 553 29 derivatives derivative NNS cord-274141-vujx538o 553 30 from from IN cord-274141-vujx538o 553 31 the the DT cord-274141-vujx538o 553 32 seeds seed NNS cord-274141-vujx538o 553 33 of of IN cord-274141-vujx538o 553 34 Aesculus Aesculus NNP cord-274141-vujx538o 553 35 turbinata turbinata NN cord-274141-vujx538o 553 36 Blume Blume NNP cord-274141-vujx538o 553 37 ( ( -LRB- cord-274141-vujx538o 553 38 Japanese japanese JJ cord-274141-vujx538o 553 39 horse horse NN cord-274141-vujx538o 553 40 chestnut chestnut NN cord-274141-vujx538o 553 41 ) ) -RRB- cord-274141-vujx538o 554 1 Middle Middle NNP cord-274141-vujx538o 554 2 East East NNP cord-274141-vujx538o 554 3 respiratory respiratory JJ cord-274141-vujx538o 554 4 syndrome syndrome NN cord-274141-vujx538o 554 5 coronavirus coronavirus NN cord-274141-vujx538o 554 6 ( ( -LRB- cord-274141-vujx538o 554 7 MERS MERS NNP cord-274141-vujx538o 554 8 - - HYPH cord-274141-vujx538o 554 9 CoV CoV NNP cord-274141-vujx538o 554 10 ) ) -RRB- cord-274141-vujx538o 554 11 outbreak outbreak NN cord-274141-vujx538o 554 12 in in IN cord-274141-vujx538o 554 13 South South NNP cord-274141-vujx538o 554 14 Korea Korea NNP cord-274141-vujx538o 554 15 , , , cord-274141-vujx538o 554 16 2015 2015 CD cord-274141-vujx538o 554 17 : : : cord-274141-vujx538o 554 18 epidemiology epidemiology NN cord-274141-vujx538o 554 19 , , , cord-274141-vujx538o 554 20 characteristics characteristic NNS cord-274141-vujx538o 554 21 and and CC cord-274141-vujx538o 554 22 public public JJ cord-274141-vujx538o 554 23 health health NN cord-274141-vujx538o 554 24 implications implication NNS cord-274141-vujx538o 554 25 A a DT cord-274141-vujx538o 554 26 crucial crucial JJ cord-274141-vujx538o 554 27 role role NN cord-274141-vujx538o 554 28 of of IN cord-274141-vujx538o 554 29 angiotensin angiotensin NN cord-274141-vujx538o 554 30 converting convert VBG cord-274141-vujx538o 554 31 enzyme enzyme NN cord-274141-vujx538o 554 32 2 2 CD cord-274141-vujx538o 554 33 ( ( -LRB- cord-274141-vujx538o 554 34 ACE2 ACE2 NNP cord-274141-vujx538o 554 35 ) ) -RRB- cord-274141-vujx538o 554 36 in in IN cord-274141-vujx538o 554 37 SARS SARS NNP cord-274141-vujx538o 554 38 coronavirus coronavirus NN cord-274141-vujx538o 554 39 - - HYPH cord-274141-vujx538o 554 40 induced induce VBN cord-274141-vujx538o 554 41 lung lung NN cord-274141-vujx538o 554 42 injury injury NN cord-274141-vujx538o 554 43 Computational computational JJ cord-274141-vujx538o 554 44 evaluation evaluation NN cord-274141-vujx538o 554 45 of of IN cord-274141-vujx538o 554 46 major major JJ cord-274141-vujx538o 554 47 components component NNS cord-274141-vujx538o 554 48 from from IN cord-274141-vujx538o 554 49 plant plant NN cord-274141-vujx538o 554 50 essential essential JJ cord-274141-vujx538o 554 51 oils oil NNS cord-274141-vujx538o 554 52 as as IN cord-274141-vujx538o 554 53 potent potent JJ cord-274141-vujx538o 554 54 inhibitors inhibitor NNS cord-274141-vujx538o 554 55 of of IN cord-274141-vujx538o 554 56 SARS SARS NNP cord-274141-vujx538o 554 57 - - HYPH cord-274141-vujx538o 554 58 CoV-2 CoV-2 NNP cord-274141-vujx538o 554 59 spike spike NN cord-274141-vujx538o 554 60 protein protein NN cord-274141-vujx538o 554 61 Inhibition inhibition NN cord-274141-vujx538o 554 62 of of IN cord-274141-vujx538o 554 63 severe severe JJ cord-274141-vujx538o 554 64 acute acute JJ cord-274141-vujx538o 554 65 respiratory respiratory JJ cord-274141-vujx538o 554 66 syndrome syndrome NN cord-274141-vujx538o 554 67 coronavirus coronavirus NN cord-274141-vujx538o 554 68 replication replication NN cord-274141-vujx538o 554 69 in in IN cord-274141-vujx538o 554 70 a a DT cord-274141-vujx538o 554 71 lethal lethal JJ cord-274141-vujx538o 554 72 SARS SARS NNP cord-274141-vujx538o 554 73 - - HYPH cord-274141-vujx538o 554 74 CoV CoV NNP cord-274141-vujx538o 554 75 BALB BALB NNP cord-274141-vujx538o 554 76 / / SYM cord-274141-vujx538o 554 77 c c NNP cord-274141-vujx538o 554 78 mouse mouse NN cord-274141-vujx538o 554 79 model model NN cord-274141-vujx538o 554 80 by by IN cord-274141-vujx538o 554 81 stinging stinging JJ cord-274141-vujx538o 554 82 nettle nettle NN cord-274141-vujx538o 554 83 lectin lectin NN cord-274141-vujx538o 554 84 , , , cord-274141-vujx538o 554 85 Urtica Urtica NNP cord-274141-vujx538o 554 86 dioica dioica NNP cord-274141-vujx538o 554 87 agglutinin agglutinin NN cord-274141-vujx538o 555 1 In in IN cord-274141-vujx538o 555 2 vitro vitro FW cord-274141-vujx538o 555 3 antiviral antiviral JJ cord-274141-vujx538o 555 4 activity activity NN cord-274141-vujx538o 555 5 of of IN cord-274141-vujx538o 555 6 phlorotannins phlorotannin NNS cord-274141-vujx538o 555 7 isolated isolate VBN cord-274141-vujx538o 555 8 from from IN cord-274141-vujx538o 555 9 Ecklonia Ecklonia NNP cord-274141-vujx538o 555 10 cava cava NN cord-274141-vujx538o 555 11 against against IN cord-274141-vujx538o 555 12 porcine porcine JJ cord-274141-vujx538o 555 13 epidemic epidemic NN cord-274141-vujx538o 555 14 diarrhea diarrhea NN cord-274141-vujx538o 555 15 coronavirus coronavirus NN cord-274141-vujx538o 555 16 infection infection NN cord-274141-vujx538o 555 17 and and CC cord-274141-vujx538o 555 18 hemagglutination hemagglutination NN cord-274141-vujx538o 555 19 Marine Marine NNP cord-274141-vujx538o 555 20 sponges sponge NNS cord-274141-vujx538o 555 21 : : : cord-274141-vujx538o 555 22 potential potential JJ cord-274141-vujx538o 555 23 sources source NNS cord-274141-vujx538o 555 24 of of IN cord-274141-vujx538o 555 25 new new JJ cord-274141-vujx538o 555 26 antimicrobial antimicrobial JJ cord-274141-vujx538o 555 27 drugs drug NNS cord-274141-vujx538o 555 28 Using use VBG cord-274141-vujx538o 555 29 herbal herbal JJ cord-274141-vujx538o 555 30 medicine medicine NN cord-274141-vujx538o 555 31 as as IN cord-274141-vujx538o 555 32 a a DT cord-274141-vujx538o 555 33 means means NN cord-274141-vujx538o 555 34 of of IN cord-274141-vujx538o 555 35 prevention prevention NN cord-274141-vujx538o 555 36 experience experience NN cord-274141-vujx538o 555 37 during during IN cord-274141-vujx538o 555 38 the the DT cord-274141-vujx538o 555 39 SARS SARS NNP cord-274141-vujx538o 555 40 crisis crisis NN cord-274141-vujx538o 555 41 Griffithsin Griffithsin NNP cord-274141-vujx538o 555 42 , , , cord-274141-vujx538o 555 43 a a DT cord-274141-vujx538o 555 44 highly highly RB cord-274141-vujx538o 555 45 potent potent JJ cord-274141-vujx538o 555 46 broad broad JJ cord-274141-vujx538o 555 47 - - HYPH cord-274141-vujx538o 555 48 spectrum spectrum NN cord-274141-vujx538o 555 49 antiviral antiviral JJ cord-274141-vujx538o 555 50 lectin lectin NN cord-274141-vujx538o 555 51 from from IN cord-274141-vujx538o 555 52 red red JJ cord-274141-vujx538o 555 53 algae algae NN cord-274141-vujx538o 555 54 : : : cord-274141-vujx538o 555 55 from from IN cord-274141-vujx538o 555 56 discovery discovery NN cord-274141-vujx538o 555 57 to to IN cord-274141-vujx538o 555 58 clinical clinical JJ cord-274141-vujx538o 555 59 application application NN cord-274141-vujx538o 555 60 Effects effect NNS cord-274141-vujx538o 555 61 of of IN cord-274141-vujx538o 555 62 Ecklonia Ecklonia NNP cord-274141-vujx538o 555 63 cava cava NN cord-274141-vujx538o 555 64 polyphenol polyphenol NN cord-274141-vujx538o 555 65 in in IN cord-274141-vujx538o 555 66 individuals individual NNS cord-274141-vujx538o 555 67 with with IN cord-274141-vujx538o 555 68 hypercholesterolemia hypercholesterolemia NN cord-274141-vujx538o 555 69 : : : cord-274141-vujx538o 555 70 a a DT cord-274141-vujx538o 555 71 pilot pilot NN cord-274141-vujx538o 555 72 study study NN cord-274141-vujx538o 555 73 Synthesis Synthesis NNP cord-274141-vujx538o 555 74 and and CC cord-274141-vujx538o 555 75 biological biological JJ cord-274141-vujx538o 555 76 evaluation evaluation NN cord-274141-vujx538o 555 77 of of IN cord-274141-vujx538o 555 78 tylophorinederived tylophorinederived NNP cord-274141-vujx538o 555 79 dibenzoquinolines dibenzoquinoline NNS cord-274141-vujx538o 555 80 as as IN cord-274141-vujx538o 555 81 orally orally RB cord-274141-vujx538o 555 82 active active JJ cord-274141-vujx538o 555 83 agents agent NNS cord-274141-vujx538o 555 84 : : : cord-274141-vujx538o 555 85 exploration exploration NN cord-274141-vujx538o 555 86 of of IN cord-274141-vujx538o 555 87 the the DT cord-274141-vujx538o 555 88 role role NN cord-274141-vujx538o 555 89 of of IN cord-274141-vujx538o 555 90 tylophorine tylophorine NN cord-274141-vujx538o 555 91 e e NNP cord-274141-vujx538o 555 92 ring ring NN cord-274141-vujx538o 555 93 on on IN cord-274141-vujx538o 555 94 biological biological JJ cord-274141-vujx538o 555 95 activity activity NN cord-274141-vujx538o 556 1 The the DT cord-274141-vujx538o 556 2 efficacy efficacy NN cord-274141-vujx538o 556 3 of of IN cord-274141-vujx538o 556 4 Chinese chinese JJ cord-274141-vujx538o 556 5 medicine medicine NN cord-274141-vujx538o 556 6 for for IN cord-274141-vujx538o 556 7 SARS SARS NNP cord-274141-vujx538o 556 8 : : : cord-274141-vujx538o 556 9 a a DT cord-274141-vujx538o 556 10 review review NN cord-274141-vujx538o 556 11 of of IN cord-274141-vujx538o 556 12 Chinese chinese JJ cord-274141-vujx538o 556 13 publications publication NNS cord-274141-vujx538o 556 14 after after IN cord-274141-vujx538o 556 15 the the DT cord-274141-vujx538o 556 16 crisis crisis NN cord-274141-vujx538o 556 17 Synthesis Synthesis NNP cord-274141-vujx538o 556 18 of of IN cord-274141-vujx538o 556 19 stilbene stilbene JJ cord-274141-vujx538o 556 20 derivatives derivative NNS cord-274141-vujx538o 556 21 with with IN cord-274141-vujx538o 556 22 inhibition inhibition NN cord-274141-vujx538o 556 23 of of IN cord-274141-vujx538o 556 24 SARS SARS NNP cord-274141-vujx538o 556 25 coronavirus coronavirus NN cord-274141-vujx538o 556 26 replication replication NN cord-274141-vujx538o 556 27 Coronavirus Coronavirus NNP cord-274141-vujx538o 556 28 infections infection NNS cord-274141-vujx538o 556 29 and and CC cord-274141-vujx538o 556 30 immune immune JJ cord-274141-vujx538o 556 31 responses response NNS cord-274141-vujx538o 556 32 Identification identification NN cord-274141-vujx538o 556 33 of of IN cord-274141-vujx538o 556 34 natural natural JJ cord-274141-vujx538o 556 35 compounds compound NNS cord-274141-vujx538o 556 36 with with IN cord-274141-vujx538o 556 37 antiviral antiviral JJ cord-274141-vujx538o 556 38 activities activity NNS cord-274141-vujx538o 556 39 against against IN cord-274141-vujx538o 556 40 SARS SARS NNP cord-274141-vujx538o 556 41 - - HYPH cord-274141-vujx538o 556 42 associated associate VBN cord-274141-vujx538o 556 43 coronavirus coronavirus NN cord-274141-vujx538o 556 44 Extracts extract NNS cord-274141-vujx538o 556 45 of of IN cord-274141-vujx538o 556 46 the the DT cord-274141-vujx538o 556 47 medicinal medicinal JJ cord-274141-vujx538o 556 48 herb herb NN cord-274141-vujx538o 556 49 Sanguisorba Sanguisorba NNP cord-274141-vujx538o 556 50 officinalis officinali NNS cord-274141-vujx538o 556 51 inhibit inhibit VBP cord-274141-vujx538o 556 52 the the DT cord-274141-vujx538o 556 53 entry entry NN cord-274141-vujx538o 556 54 of of IN cord-274141-vujx538o 556 55 human human JJ cord-274141-vujx538o 556 56 immunodeficiency immunodeficiency NN cord-274141-vujx538o 556 57 virus-1 virus-1 NNP cord-274141-vujx538o 556 58 Anti Anti NNP cord-274141-vujx538o 556 59 - - NNP cord-274141-vujx538o 556 60 SARS SARS NNP cord-274141-vujx538o 556 61 coronavirus coronavirus NN cord-274141-vujx538o 556 62 3C 3c NN cord-274141-vujx538o 556 63 - - HYPH cord-274141-vujx538o 556 64 like like JJ cord-274141-vujx538o 556 65 protease protease NN cord-274141-vujx538o 556 66 effects effect NNS cord-274141-vujx538o 556 67 of of IN cord-274141-vujx538o 556 68 Isatis Isatis NNP cord-274141-vujx538o 556 69 indigotica indigotica NN cord-274141-vujx538o 556 70 root root NN cord-274141-vujx538o 556 71 and and CC cord-274141-vujx538o 556 72 plant plant NN cord-274141-vujx538o 556 73 - - HYPH cord-274141-vujx538o 556 74 derived derive VBN cord-274141-vujx538o 556 75 phenolic phenolic JJ cord-274141-vujx538o 556 76 compounds compound NNS cord-274141-vujx538o 557 1 Effective effective JJ cord-274141-vujx538o 557 2 inhibition inhibition NN cord-274141-vujx538o 557 3 of of IN cord-274141-vujx538o 557 4 MERS MERS NNP cord-274141-vujx538o 557 5 - - HYPH cord-274141-vujx538o 557 6 CoV cov NN cord-274141-vujx538o 557 7 infection infection NN cord-274141-vujx538o 557 8 by by IN cord-274141-vujx538o 557 9 resveratrol resveratrol NN cord-274141-vujx538o 557 10 Traditional traditional JJ cord-274141-vujx538o 557 11 Chinese chinese JJ cord-274141-vujx538o 557 12 medicine medicine NN cord-274141-vujx538o 557 13 is be VBZ cord-274141-vujx538o 557 14 a a DT cord-274141-vujx538o 557 15 resource resource NN cord-274141-vujx538o 557 16 for for IN cord-274141-vujx538o 557 17 drug drug NN cord-274141-vujx538o 557 18 discovery discovery NN cord-274141-vujx538o 557 19 against against IN cord-274141-vujx538o 557 20 2019 2019 CD cord-274141-vujx538o 557 21 novel novel JJ cord-274141-vujx538o 557 22 coronavirus coronavirus NN cord-274141-vujx538o 557 23 ( ( -LRB- cord-274141-vujx538o 557 24 SARS SARS NNP cord-274141-vujx538o 557 25 - - HYPH cord-274141-vujx538o 557 26 CoV-2 CoV-2 NNP cord-274141-vujx538o 557 27 ) ) -RRB- cord-274141-vujx538o 558 1 Chinese chinese JJ cord-274141-vujx538o 558 2 herbal herbal JJ cord-274141-vujx538o 558 3 medicine medicine NN cord-274141-vujx538o 558 4 for for IN cord-274141-vujx538o 558 5 severe severe JJ cord-274141-vujx538o 558 6 acute acute JJ cord-274141-vujx538o 558 7 respiratory respiratory JJ cord-274141-vujx538o 558 8 syndrome syndrome NN cord-274141-vujx538o 558 9 : : : cord-274141-vujx538o 558 10 a a DT cord-274141-vujx538o 558 11 systematic systematic JJ cord-274141-vujx538o 558 12 review review NN cord-274141-vujx538o 558 13 and and CC cord-274141-vujx538o 558 14 metaanalysis metaanalysis NN cord-274141-vujx538o 558 15 Chinese chinese JJ cord-274141-vujx538o 558 16 herbs herb NNS cord-274141-vujx538o 558 17 combined combine VBN cord-274141-vujx538o 558 18 with with IN cord-274141-vujx538o 558 19 Western western JJ cord-274141-vujx538o 558 20 medicine medicine NN cord-274141-vujx538o 558 21 for for IN cord-274141-vujx538o 558 22 severe severe JJ cord-274141-vujx538o 558 23 acute acute JJ cord-274141-vujx538o 558 24 respiratory respiratory JJ cord-274141-vujx538o 558 25 syndrome syndrome NN cord-274141-vujx538o 558 26 ( ( -LRB- cord-274141-vujx538o 558 27 SARS SARS NNP cord-274141-vujx538o 558 28 ) ) -RRB- cord-274141-vujx538o 559 1 The the DT cord-274141-vujx538o 559 2 roles role NNS cord-274141-vujx538o 559 3 of of IN cord-274141-vujx538o 559 4 direct direct JJ cord-274141-vujx538o 559 5 recognition recognition NN cord-274141-vujx538o 559 6 by by IN cord-274141-vujx538o 559 7 animal animal NN cord-274141-vujx538o 559 8 lectins lectin NNS cord-274141-vujx538o 559 9 in in IN cord-274141-vujx538o 559 10 antiviral antiviral JJ cord-274141-vujx538o 559 11 immunity immunity NN cord-274141-vujx538o 559 12 and and CC cord-274141-vujx538o 559 13 viral viral JJ cord-274141-vujx538o 559 14 pathogenesis pathogenesis NN cord-274141-vujx538o 559 15 Phytochemical Phytochemical NNP cord-274141-vujx538o 559 16 analysis analysis NN cord-274141-vujx538o 559 17 and and CC cord-274141-vujx538o 559 18 in in IN cord-274141-vujx538o 559 19 vitro vitro FW cord-274141-vujx538o 559 20 antiviral antiviral JJ cord-274141-vujx538o 559 21 activities activity NNS cord-274141-vujx538o 559 22 of of IN cord-274141-vujx538o 559 23 the the DT cord-274141-vujx538o 559 24 essential essential JJ cord-274141-vujx538o 559 25 oils oil NNS cord-274141-vujx538o 559 26 of of IN cord-274141-vujx538o 559 27 seven seven CD cord-274141-vujx538o 559 28 Lebanon Lebanon NNP cord-274141-vujx538o 559 29 species specie NNS cord-274141-vujx538o 559 30 Genomic genomic JJ cord-274141-vujx538o 559 31 characterisation characterisation NN cord-274141-vujx538o 559 32 and and CC cord-274141-vujx538o 559 33 epidemiology epidemiology NN cord-274141-vujx538o 559 34 of of IN cord-274141-vujx538o 559 35 2019 2019 CD cord-274141-vujx538o 559 36 novel novel JJ cord-274141-vujx538o 559 37 coronavirus coronavirus NN cord-274141-vujx538o 559 38 : : : cord-274141-vujx538o 559 39 implications implication NNS cord-274141-vujx538o 559 40 for for IN cord-274141-vujx538o 559 41 virus virus NN cord-274141-vujx538o 559 42 origins origin NNS cord-274141-vujx538o 559 43 and and CC cord-274141-vujx538o 559 44 receptor receptor NN cord-274141-vujx538o 559 45 binding bind VBG cord-274141-vujx538o 559 46 Ethnomedicinal ethnomedicinal JJ cord-274141-vujx538o 559 47 wisdom wisdom NN cord-274141-vujx538o 559 48 : : : cord-274141-vujx538o 559 49 an an DT cord-274141-vujx538o 559 50 approach approach NN cord-274141-vujx538o 559 51 for for IN cord-274141-vujx538o 559 52 antiviral antiviral JJ cord-274141-vujx538o 559 53 drug drug NN cord-274141-vujx538o 559 54 development development NN cord-274141-vujx538o 559 55 Nutraceuticals Nutraceuticals NNPS cord-274141-vujx538o 559 56 have have VBP cord-274141-vujx538o 559 57 potential potential NN cord-274141-vujx538o 559 58 for for IN cord-274141-vujx538o 559 59 boosting boost VBG cord-274141-vujx538o 559 60 the the DT cord-274141-vujx538o 559 61 type type NN cord-274141-vujx538o 559 62 1 1 CD cord-274141-vujx538o 559 63 interferon interferon NN cord-274141-vujx538o 559 64 response response NN cord-274141-vujx538o 559 65 to to IN cord-274141-vujx538o 559 66 RNA RNA NNP cord-274141-vujx538o 559 67 viruses virus NNS cord-274141-vujx538o 559 68 including include VBG cord-274141-vujx538o 559 69 influenza influenza NN cord-274141-vujx538o 559 70 and and CC cord-274141-vujx538o 559 71 coronavirus coronavirus NN cord-274141-vujx538o 559 72 Drug drug NN cord-274141-vujx538o 559 73 repurposing repurpose VBG cord-274141-vujx538o 559 74 for for IN cord-274141-vujx538o 559 75 viral viral JJ cord-274141-vujx538o 559 76 infectious infectious JJ cord-274141-vujx538o 559 77 diseases disease NNS cord-274141-vujx538o 559 78 : : : cord-274141-vujx538o 559 79 how how WRB cord-274141-vujx538o 559 80 far far RB cord-274141-vujx538o 559 81 are be VBP cord-274141-vujx538o 559 82 we -PRON- PRP cord-274141-vujx538o 559 83 ? ? . cord-274141-vujx538o 560 1 Investigation investigation NN cord-274141-vujx538o 560 2 of of IN cord-274141-vujx538o 560 3 the the DT cord-274141-vujx538o 560 4 influence influence NN cord-274141-vujx538o 560 5 of of IN cord-274141-vujx538o 560 6 EPs ep NNS cord-274141-vujx538o 561 1 ® ® LS cord-274141-vujx538o 561 2 7630 7630 CD cord-274141-vujx538o 561 3 , , , cord-274141-vujx538o 561 4 a a DT cord-274141-vujx538o 561 5 herbal herbal JJ cord-274141-vujx538o 561 6 drug drug NN cord-274141-vujx538o 561 7 preparation preparation NN cord-274141-vujx538o 561 8 from from IN cord-274141-vujx538o 561 9 Pelargonium Pelargonium NNP cord-274141-vujx538o 561 10 sidoides sidoide NNS cord-274141-vujx538o 561 11 , , , cord-274141-vujx538o 561 12 on on IN cord-274141-vujx538o 561 13 replication replication NN cord-274141-vujx538o 561 14 of of IN cord-274141-vujx538o 561 15 a a DT cord-274141-vujx538o 561 16 broad broad JJ cord-274141-vujx538o 561 17 panel panel NN cord-274141-vujx538o 561 18 of of IN cord-274141-vujx538o 561 19 respiratory respiratory JJ cord-274141-vujx538o 561 20 viruses virus NNS cord-274141-vujx538o 561 21 Antiviral antiviral JJ cord-274141-vujx538o 561 22 lectins lectin NNS cord-274141-vujx538o 561 23 : : : cord-274141-vujx538o 561 24 selective selective JJ cord-274141-vujx538o 561 25 inhibitors inhibitor NNS cord-274141-vujx538o 561 26 of of IN cord-274141-vujx538o 561 27 viral viral JJ cord-274141-vujx538o 561 28 entry entry NN cord-274141-vujx538o 561 29 Green green JJ cord-274141-vujx538o 561 30 synthesis synthesis NN cord-274141-vujx538o 561 31 of of IN cord-274141-vujx538o 561 32 silver silver NN cord-274141-vujx538o 561 33 nanoparticles nanoparticle NNS cord-274141-vujx538o 561 34 from from IN cord-274141-vujx538o 561 35 extracts extract NNS cord-274141-vujx538o 561 36 of of IN cord-274141-vujx538o 561 37 Pechuelloeschea Pechuelloeschea NNP cord-274141-vujx538o 561 38 leubnitziae leubnitziae NN cord-274141-vujx538o 561 39 : : : cord-274141-vujx538o 561 40 their -PRON- PRP$ cord-274141-vujx538o 561 41 anti anti JJ cord-274141-vujx538o 561 42 - - JJ cord-274141-vujx538o 561 43 proliferative proliferative JJ cord-274141-vujx538o 561 44 activity activity NN cord-274141-vujx538o 561 45 against against IN cord-274141-vujx538o 561 46 the the DT cord-274141-vujx538o 561 47 U87 U87 NNP cord-274141-vujx538o 561 48 cell cell NN cord-274141-vujx538o 561 49 line line NN cord-274141-vujx538o 561 50 Angiotensin Angiotensin NNP cord-274141-vujx538o 561 51 converting convert VBG cord-274141-vujx538o 561 52 enzyme enzyme NN cord-274141-vujx538o 561 53 - - HYPH cord-274141-vujx538o 561 54 inhibitory inhibitory JJ cord-274141-vujx538o 561 55 triterpens triterpen NNS cord-274141-vujx538o 561 56 from from IN cord-274141-vujx538o 561 57 Ganoderma Ganoderma NNP cord-274141-vujx538o 561 58 lucidum lucidum NN cord-274141-vujx538o 561 59 Broad Broad NNP cord-274141-vujx538o 561 60 - - HYPH cord-274141-vujx538o 561 61 spectrum spectrum NN cord-274141-vujx538o 561 62 antiviral antiviral JJ cord-274141-vujx538o 561 63 activity activity NN cord-274141-vujx538o 561 64 of of IN cord-274141-vujx538o 561 65 the the DT cord-274141-vujx538o 561 66 eIF4A eif4a CD cord-274141-vujx538o 561 67 inhibitor inhibitor NN cord-274141-vujx538o 561 68 silvestrol silvestrol NNP cord-274141-vujx538o 561 69 against against IN cord-274141-vujx538o 561 70 corona corona NN cord-274141-vujx538o 561 71 - - HYPH cord-274141-vujx538o 561 72 and and CC cord-274141-vujx538o 561 73 picornaviruses picornaviruse VBZ cord-274141-vujx538o 561 74 Potential Potential NNP cord-274141-vujx538o 561 75 of of IN cord-274141-vujx538o 561 76 flavonoid flavonoid NN cord-274141-vujx538o 561 77 - - HYPH cord-274141-vujx538o 561 78 inspired inspire VBN cord-274141-vujx538o 561 79 phytomedicines phytomedicine NNS cord-274141-vujx538o 561 80 against against IN cord-274141-vujx538o 561 81 COVID-19 COVID-19 NNP cord-274141-vujx538o 561 82 Potential Potential NNP cord-274141-vujx538o 561 83 of of IN cord-274141-vujx538o 561 84 Cupressus Cupressus NNP cord-274141-vujx538o 561 85 sempervirens sempervirens NN cord-274141-vujx538o 561 86 ( ( -LRB- cord-274141-vujx538o 561 87 Mediterranean Mediterranean NNP cord-274141-vujx538o 561 88 cypress cypress NNP cord-274141-vujx538o 561 89 ) ) -RRB- cord-274141-vujx538o 561 90 in in IN cord-274141-vujx538o 561 91 health health NN cord-274141-vujx538o 561 92 Diarylheptanoids Diarylheptanoids NNP cord-274141-vujx538o 561 93 from from IN cord-274141-vujx538o 561 94 Alnus Alnus NNP cord-274141-vujx538o 561 95 japonica japonica NN cord-274141-vujx538o 561 96 inhibit inhibit VBP cord-274141-vujx538o 561 97 papain papain NN cord-274141-vujx538o 561 98 - - HYPH cord-274141-vujx538o 561 99 like like JJ cord-274141-vujx538o 561 100 protease protease NN cord-274141-vujx538o 561 101 of of IN cord-274141-vujx538o 561 102 severe severe JJ cord-274141-vujx538o 561 103 acute acute JJ cord-274141-vujx538o 561 104 respiratory respiratory JJ cord-274141-vujx538o 561 105 syndrome syndrome NN cord-274141-vujx538o 561 106 coronavirus coronavirus NN cord-274141-vujx538o 561 107 Tanshinones Tanshinones NNP cord-274141-vujx538o 561 108 as as IN cord-274141-vujx538o 561 109 selective selective JJ cord-274141-vujx538o 561 110 and and CC cord-274141-vujx538o 561 111 slow slow RB cord-274141-vujx538o 561 112 - - HYPH cord-274141-vujx538o 561 113 binding bind VBG cord-274141-vujx538o 561 114 inhibitors inhibitor NNS cord-274141-vujx538o 561 115 for for IN cord-274141-vujx538o 561 116 SARS SARS NNP cord-274141-vujx538o 561 117 - - HYPH cord-274141-vujx538o 561 118 CoV CoV NNP cord-274141-vujx538o 561 119 cysteine cysteine NN cord-274141-vujx538o 561 120 proteases protease NNS cord-274141-vujx538o 561 121 Dieckol Dieckol NNP cord-274141-vujx538o 561 122 , , , cord-274141-vujx538o 561 123 a a DT cord-274141-vujx538o 561 124 SARS SARS NNP cord-274141-vujx538o 561 125 - - HYPH cord-274141-vujx538o 561 126 CoV CoV NNP cord-274141-vujx538o 561 127 3CL 3CL NNP cord-274141-vujx538o 561 128 pro pro JJ cord-274141-vujx538o 561 129 inhibitor inhibitor NN cord-274141-vujx538o 561 130 , , , cord-274141-vujx538o 561 131 isolated isolate VBN cord-274141-vujx538o 561 132 from from IN cord-274141-vujx538o 561 133 the the DT cord-274141-vujx538o 561 134 edible edible JJ cord-274141-vujx538o 561 135 brown brown JJ cord-274141-vujx538o 561 136 algae algae NN cord-274141-vujx538o 561 137 Ecklonia Ecklonia NNP cord-274141-vujx538o 561 138 cava cava NN cord-274141-vujx538o 561 139 Volatile volatile JJ cord-274141-vujx538o 561 140 oils oil NNS cord-274141-vujx538o 561 141 : : : cord-274141-vujx538o 561 142 potential potential JJ cord-274141-vujx538o 561 143 agents agent NNS cord-274141-vujx538o 561 144 for for IN cord-274141-vujx538o 561 145 the the DT cord-274141-vujx538o 561 146 treatment treatment NN cord-274141-vujx538o 561 147 of of IN cord-274141-vujx538o 561 148 respiratory respiratory JJ cord-274141-vujx538o 561 149 infections infection NNS cord-274141-vujx538o 562 1 Recent recent JJ cord-274141-vujx538o 562 2 discovery discovery NN cord-274141-vujx538o 562 3 and and CC cord-274141-vujx538o 562 4 development development NN cord-274141-vujx538o 562 5 of of IN cord-274141-vujx538o 562 6 inhibitors inhibitor NNS cord-274141-vujx538o 562 7 targeting target VBG cord-274141-vujx538o 562 8 coronaviruses coronaviruse NNS cord-274141-vujx538o 562 9 Coronavirus Coronavirus NNP cord-274141-vujx538o 562 10 ( ( -LRB- cord-274141-vujx538o 562 11 COVID-19 COVID-19 NNP cord-274141-vujx538o 562 12 ) ) -RRB- cord-274141-vujx538o 562 13 , , , cord-274141-vujx538o 562 14 first first JJ cord-274141-vujx538o 562 15 indication indication NN cord-274141-vujx538o 562 16 of of IN cord-274141-vujx538o 562 17 efficacy efficacy NN cord-274141-vujx538o 562 18 of of IN cord-274141-vujx538o 562 19 gene gene NN cord-274141-vujx538o 562 20 - - HYPH cord-274141-vujx538o 562 21 eden eden NNP cord-274141-vujx538o 562 22 - - HYPH cord-274141-vujx538o 562 23 VIR VIR NNP cord-274141-vujx538o 562 24 / / SYM cord-274141-vujx538o 562 25 novirin novirin NN cord-274141-vujx538o 562 26 in in IN cord-274141-vujx538o 562 27 SARS SARS NNP cord-274141-vujx538o 562 28 - - HYPH cord-274141-vujx538o 562 29 CoV-2 CoV-2 NNP cord-274141-vujx538o 562 30 infections infection NNS cord-274141-vujx538o 562 31 Anti anti JJ cord-274141-vujx538o 562 32 - - JJ cord-274141-vujx538o 562 33 HIV hiv JJ cord-274141-vujx538o 562 34 activity activity NN cord-274141-vujx538o 562 35 of of IN cord-274141-vujx538o 562 36 southern southern JJ cord-274141-vujx538o 562 37 African african JJ cord-274141-vujx538o 562 38 plants plant NNS cord-274141-vujx538o 562 39 : : : cord-274141-vujx538o 562 40 current current JJ cord-274141-vujx538o 562 41 developments development NNS cord-274141-vujx538o 562 42 , , , cord-274141-vujx538o 562 43 phytochemistry phytochemistry NN cord-274141-vujx538o 562 44 and and CC cord-274141-vujx538o 562 45 future future JJ cord-274141-vujx538o 562 46 research research NN cord-274141-vujx538o 562 47 Medicinal medicinal JJ cord-274141-vujx538o 562 48 plants plant NNS cord-274141-vujx538o 562 49 of of IN cord-274141-vujx538o 562 50 the the DT cord-274141-vujx538o 562 51 genus genus JJ cord-274141-vujx538o 562 52 Betula Betula NNP cord-274141-vujx538o 562 53 - - HYPH cord-274141-vujx538o 562 54 traditional traditional JJ cord-274141-vujx538o 562 55 uses use NNS cord-274141-vujx538o 562 56 and and CC cord-274141-vujx538o 562 57 a a DT cord-274141-vujx538o 562 58 phytochemical phytochemical JJ cord-274141-vujx538o 562 59 - - HYPH cord-274141-vujx538o 562 60 pharmacological pharmacological JJ cord-274141-vujx538o 562 61 review review NN cord-274141-vujx538o 562 62 COVID-19 COVID-19 NNP cord-274141-vujx538o 562 63 and and CC cord-274141-vujx538o 562 64 Italy Italy NNP cord-274141-vujx538o 562 65 : : : cord-274141-vujx538o 563 1 what what WP cord-274141-vujx538o 563 2 next next JJ cord-274141-vujx538o 563 3 ? ? . cord-274141-vujx538o 564 1 Self self NN cord-274141-vujx538o 564 2 - - HYPH cord-274141-vujx538o 564 3 care care NN cord-274141-vujx538o 564 4 for for IN cord-274141-vujx538o 564 5 common common JJ cord-274141-vujx538o 564 6 colds cold NNS cord-274141-vujx538o 564 7 : : : cord-274141-vujx538o 564 8 the the DT cord-274141-vujx538o 564 9 pivotal pivotal JJ cord-274141-vujx538o 564 10 role role NN cord-274141-vujx538o 564 11 of of IN cord-274141-vujx538o 564 12 vitamin vitamin NN cord-274141-vujx538o 564 13 D d NN cord-274141-vujx538o 564 14 , , , cord-274141-vujx538o 564 15 vitamin vitamin NN cord-274141-vujx538o 564 16 C c NN cord-274141-vujx538o 564 17 , , , cord-274141-vujx538o 564 18 zinc zinc NN cord-274141-vujx538o 564 19 , , , cord-274141-vujx538o 564 20 and and CC cord-274141-vujx538o 564 21 Echinacea Echinacea NNP cord-274141-vujx538o 564 22 in in IN cord-274141-vujx538o 564 23 three three CD cord-274141-vujx538o 564 24 main main JJ cord-274141-vujx538o 564 25 immune immune JJ cord-274141-vujx538o 564 26 interactive interactive JJ cord-274141-vujx538o 564 27 clusters cluster NNS cord-274141-vujx538o 564 28 ( ( -LRB- cord-274141-vujx538o 564 29 physical physical JJ cord-274141-vujx538o 564 30 barriers barrier NNS cord-274141-vujx538o 564 31 , , , cord-274141-vujx538o 564 32 innate innate JJ cord-274141-vujx538o 564 33 and and CC cord-274141-vujx538o 564 34 adaptive adaptive JJ cord-274141-vujx538o 564 35 immunity immunity NN cord-274141-vujx538o 564 36 ) ) -RRB- cord-274141-vujx538o 564 37 involved involve VBN cord-274141-vujx538o 564 38 during during IN cord-274141-vujx538o 564 39 an an DT cord-274141-vujx538o 564 40 episode episode NN cord-274141-vujx538o 564 41 of of IN cord-274141-vujx538o 564 42 common common JJ cord-274141-vujx538o 564 43 colds cold NNS cord-274141-vujx538o 564 44 - - : cord-274141-vujx538o 564 45 practical practical JJ cord-274141-vujx538o 564 46 advice advice NN cord-274141-vujx538o 564 47 on on IN cord-274141-vujx538o 564 48 dosages dosage NNS cord-274141-vujx538o 564 49 and and CC cord-274141-vujx538o 564 50 on on IN cord-274141-vujx538o 564 51 the the DT cord-274141-vujx538o 564 52 time time NN cord-274141-vujx538o 564 53 to to TO cord-274141-vujx538o 564 54 take take VB cord-274141-vujx538o 564 55 these these DT cord-274141-vujx538o 564 56 nutrients nutrient NNS cord-274141-vujx538o 564 57 / / SYM cord-274141-vujx538o 564 58 botanicals botanical NNS cord-274141-vujx538o 564 59 in in IN cord-274141-vujx538o 564 60 order order NN cord-274141-vujx538o 564 61 to to TO cord-274141-vujx538o 564 62 prevent prevent VB cord-274141-vujx538o 564 63 or or CC cord-274141-vujx538o 564 64 treat treat VB cord-274141-vujx538o 564 65 common common JJ cord-274141-vujx538o 564 66 colds cold NNS cord-274141-vujx538o 565 1 Lycorine Lycorine NNP cord-274141-vujx538o 565 2 : : : cord-274141-vujx538o 565 3 a a DT cord-274141-vujx538o 565 4 prospective prospective JJ cord-274141-vujx538o 565 5 natural natural JJ cord-274141-vujx538o 565 6 lead lead NN cord-274141-vujx538o 565 7 for for IN cord-274141-vujx538o 565 8 anticancer anticancer JJ cord-274141-vujx538o 565 9 drug drug NN cord-274141-vujx538o 565 10 discovery discovery NN cord-274141-vujx538o 566 1 Biflavonoids Biflavonoids NNP cord-274141-vujx538o 566 2 from from IN cord-274141-vujx538o 566 3 Torreya Torreya NNP cord-274141-vujx538o 566 4 nucifera nucifera JJ cord-274141-vujx538o 566 5 displaying display VBG cord-274141-vujx538o 566 6 SARS SARS NNP cord-274141-vujx538o 566 7 - - HYPH cord-274141-vujx538o 566 8 CoV CoV NNP cord-274141-vujx538o 566 9 3CL 3CL NNP cord-274141-vujx538o 566 10 pro pro JJ cord-274141-vujx538o 566 11 inhibition inhibition NN cord-274141-vujx538o 566 12 SARS SARS NNP cord-274141-vujx538o 566 13 - - HYPH cord-274141-vujx538o 566 14 CoV CoV NNP cord-274141-vujx538o 566 15 3CL 3CL NNP cord-274141-vujx538o 566 16 pro pro JJ cord-274141-vujx538o 566 17 inhibitory inhibitory JJ cord-274141-vujx538o 566 18 effects effect NNS cord-274141-vujx538o 566 19 of of IN cord-274141-vujx538o 566 20 quinone quinone NN cord-274141-vujx538o 566 21 - - HYPH cord-274141-vujx538o 566 22 methide methide JJ cord-274141-vujx538o 566 23 triterpenes triterpene NNS cord-274141-vujx538o 566 24 from from IN cord-274141-vujx538o 566 25 Tripterygium Tripterygium NNP cord-274141-vujx538o 566 26 regelii regelii NNP cord-274141-vujx538o 567 1 Aesculus Aesculus NNP cord-274141-vujx538o 567 2 hippocastanum hippocastanum NNP cord-274141-vujx538o 567 3 L. L. NNP cord-274141-vujx538o 567 4 seed seed NN cord-274141-vujx538o 567 5 extract extract NN cord-274141-vujx538o 567 6 shows show VBZ cord-274141-vujx538o 567 7 virucidal virucidal JJ cord-274141-vujx538o 567 8 and and CC cord-274141-vujx538o 567 9 antiviral antiviral JJ cord-274141-vujx538o 567 10 activities activity NNS cord-274141-vujx538o 567 11 against against IN cord-274141-vujx538o 567 12 respiratory respiratory JJ cord-274141-vujx538o 567 13 syncytial syncytial JJ cord-274141-vujx538o 567 14 virus virus NN cord-274141-vujx538o 567 15 ( ( -LRB- cord-274141-vujx538o 567 16 RSV RSV NNP cord-274141-vujx538o 567 17 ) ) -RRB- cord-274141-vujx538o 567 18 and and CC cord-274141-vujx538o 567 19 reduces reduce VBZ cord-274141-vujx538o 567 20 lung lung NN cord-274141-vujx538o 567 21 inflammation inflammation NN cord-274141-vujx538o 567 22 in in IN cord-274141-vujx538o 567 23 vivo vivo FW cord-274141-vujx538o 567 24 Use Use NNP cord-274141-vujx538o 567 25 of of IN cord-274141-vujx538o 567 26 Echinaforce Echinaforce NNP cord-274141-vujx538o 567 27 to to TO cord-274141-vujx538o 567 28 prevent prevent VB cord-274141-vujx538o 567 29 coronavirus coronavirus NN cord-274141-vujx538o 567 30 infections infection NNS cord-274141-vujx538o 567 31 Myricetin Myricetin NNP cord-274141-vujx538o 567 32 : : : cord-274141-vujx538o 567 33 a a DT cord-274141-vujx538o 567 34 dietary dietary JJ cord-274141-vujx538o 567 35 molecule molecule NN cord-274141-vujx538o 567 36 with with IN cord-274141-vujx538o 567 37 diverse diverse JJ cord-274141-vujx538o 567 38 biological biological JJ cord-274141-vujx538o 567 39 activities activity NNS cord-274141-vujx538o 568 1 Triterpenoids triterpenoid NNS cord-274141-vujx538o 568 2 manipulate manipulate VBP cord-274141-vujx538o 568 3 a a DT cord-274141-vujx538o 568 4 broad broad JJ cord-274141-vujx538o 568 5 range range NN cord-274141-vujx538o 568 6 of of IN cord-274141-vujx538o 568 7 virushost virushost NN cord-274141-vujx538o 568 8 fusion fusion NN cord-274141-vujx538o 568 9 via via IN cord-274141-vujx538o 568 10 wrapping wrap VBG cord-274141-vujx538o 568 11 the the DT cord-274141-vujx538o 568 12 HR2 HR2 NNP cord-274141-vujx538o 568 13 domain domain NN cord-274141-vujx538o 568 14 prevalent prevalent JJ cord-274141-vujx538o 568 15 in in IN cord-274141-vujx538o 568 16 viral viral JJ cord-274141-vujx538o 568 17 envelopes envelope NNS cord-274141-vujx538o 569 1 Different different JJ cord-274141-vujx538o 569 2 host host NN cord-274141-vujx538o 569 3 cell cell NN cord-274141-vujx538o 569 4 proteases protease NNS cord-274141-vujx538o 569 5 activate activate VBP cord-274141-vujx538o 569 6 the the DT cord-274141-vujx538o 569 7 SARS SARS NNP cord-274141-vujx538o 569 8 - - HYPH cord-274141-vujx538o 569 9 coronavirus coronavirus NN cord-274141-vujx538o 569 10 spikeprotein spikeprotein NN cord-274141-vujx538o 569 11 for for IN cord-274141-vujx538o 569 12 cell cell NN cord-274141-vujx538o 569 13 - - HYPH cord-274141-vujx538o 569 14 cell cell NN cord-274141-vujx538o 569 15 and and CC cord-274141-vujx538o 569 16 virus virus NN cord-274141-vujx538o 569 17 - - HYPH cord-274141-vujx538o 569 18 cell cell NN cord-274141-vujx538o 569 19 fusion fusion NN cord-274141-vujx538o 569 20 Inhibitors Inhibitors NNPS cord-274141-vujx538o 569 21 of of IN cord-274141-vujx538o 569 22 cathepsin cathepsin NN cord-274141-vujx538o 570 1 L l NN cord-274141-vujx538o 570 2 prevent prevent VBP cord-274141-vujx538o 570 3 severe severe JJ cord-274141-vujx538o 570 4 acute acute JJ cord-274141-vujx538o 570 5 respiratory respiratory JJ cord-274141-vujx538o 570 6 syndrome syndrome NN cord-274141-vujx538o 570 7 coronavirus coronavirus NN cord-274141-vujx538o 570 8 entry entry NN cord-274141-vujx538o 570 9 Structural structural JJ cord-274141-vujx538o 570 10 basis basis NN cord-274141-vujx538o 570 11 of of IN cord-274141-vujx538o 570 12 SARS SARS NNP cord-274141-vujx538o 570 13 - - HYPH cord-274141-vujx538o 570 14 CoV-2 CoV-2 NNP cord-274141-vujx538o 570 15 3CL 3cl CD cord-274141-vujx538o 570 16 pro pro JJ cord-274141-vujx538o 570 17 and and CC cord-274141-vujx538o 570 18 anti anti JJ cord-274141-vujx538o 570 19 - - JJ cord-274141-vujx538o 570 20 COVID-19 covid-19 JJ cord-274141-vujx538o 570 21 drug drug NN cord-274141-vujx538o 570 22 discovery discovery NN cord-274141-vujx538o 570 23 from from IN cord-274141-vujx538o 570 24 medicinal medicinal JJ cord-274141-vujx538o 570 25 plants plant NNS cord-274141-vujx538o 570 26 EPs EPs . cord-274141-vujx538o 571 1 ® ® LS cord-274141-vujx538o 571 2 7630 7630 CD cord-274141-vujx538o 572 1 ( ( -LRB- cord-274141-vujx538o 572 2 Umckaloabo Umckaloabo NNP cord-274141-vujx538o 572 3 ® ® POS cord-274141-vujx538o 572 4 ) ) -RRB- cord-274141-vujx538o 572 5 , , , cord-274141-vujx538o 572 6 an an DT cord-274141-vujx538o 572 7 extract extract NN cord-274141-vujx538o 572 8 from from IN cord-274141-vujx538o 572 9 Pelargonium Pelargonium NNP cord-274141-vujx538o 572 10 sidoides sidoide NNS cord-274141-vujx538o 572 11 roots root NNS cord-274141-vujx538o 572 12 , , , cord-274141-vujx538o 572 13 exerts exert VBZ cord-274141-vujx538o 572 14 anti anti JJ cord-274141-vujx538o 572 15 - - JJ cord-274141-vujx538o 572 16 influenza influenza JJ cord-274141-vujx538o 572 17 virus virus NN cord-274141-vujx538o 572 18 activity activity NN cord-274141-vujx538o 572 19 in in IN cord-274141-vujx538o 572 20 vitro vitro FW cord-274141-vujx538o 572 21 and and CC cord-274141-vujx538o 572 22 in in IN cord-274141-vujx538o 572 23 vivo vivo NN cord-274141-vujx538o 573 1 COVID-19 covid-19 VB cord-274141-vujx538o 573 2 : : : cord-274141-vujx538o 573 3 a a DT cord-274141-vujx538o 573 4 promising promising JJ cord-274141-vujx538o 573 5 cure cure NN cord-274141-vujx538o 573 6 for for IN cord-274141-vujx538o 573 7 the the DT cord-274141-vujx538o 573 8 global global JJ cord-274141-vujx538o 573 9 panic panic NN cord-274141-vujx538o 573 10 Receptor Receptor NNP cord-274141-vujx538o 573 11 recognition recognition NN cord-274141-vujx538o 573 12 by by IN cord-274141-vujx538o 573 13 the the DT cord-274141-vujx538o 573 14 novel novel JJ cord-274141-vujx538o 573 15 coronavirus coronavirus NN cord-274141-vujx538o 573 16 from from IN cord-274141-vujx538o 573 17 Wuhan Wuhan NNP cord-274141-vujx538o 573 18 : : : cord-274141-vujx538o 573 19 an an DT cord-274141-vujx538o 573 20 analysis analysis NN cord-274141-vujx538o 573 21 based base VBN cord-274141-vujx538o 573 22 on on IN cord-274141-vujx538o 573 23 decadelong decadelong JJ cord-274141-vujx538o 573 24 structural structural JJ cord-274141-vujx538o 573 25 studies study NNS cord-274141-vujx538o 573 26 of of IN cord-274141-vujx538o 573 27 SARS SARS NNP cord-274141-vujx538o 573 28 coronavirus coronavirus NN cord-274141-vujx538o 573 29 Glycyrrhizic Glycyrrhizic NNP cord-274141-vujx538o 573 30 acid acid NN cord-274141-vujx538o 573 31 as as IN cord-274141-vujx538o 573 32 the the DT cord-274141-vujx538o 573 33 antiviral antiviral JJ cord-274141-vujx538o 573 34 component component NN cord-274141-vujx538o 573 35 of of IN cord-274141-vujx538o 573 36 Glycyrrhiza Glycyrrhiza NNP cord-274141-vujx538o 573 37 uralensis uralensis NN cord-274141-vujx538o 573 38 Fisch Fisch NNP cord-274141-vujx538o 573 39 . . . cord-274141-vujx538o 574 1 against against IN cord-274141-vujx538o 574 2 coxsackievirus coxsackievirus NNP cord-274141-vujx538o 574 3 A16 A16 NNP cord-274141-vujx538o 574 4 and and CC cord-274141-vujx538o 574 5 enterovirus enterovirus NN cord-274141-vujx538o 574 6 71 71 CD cord-274141-vujx538o 574 7 of of IN cord-274141-vujx538o 574 8 hand hand NN cord-274141-vujx538o 574 9 foot foot NN cord-274141-vujx538o 574 10 and and CC cord-274141-vujx538o 574 11 mouth mouth NN cord-274141-vujx538o 574 12 disease disease NN cord-274141-vujx538o 574 13 Discovery Discovery NNP cord-274141-vujx538o 574 14 of of IN cord-274141-vujx538o 574 15 unsymmetrical unsymmetrical JJ cord-274141-vujx538o 574 16 aromatic aromatic JJ cord-274141-vujx538o 574 17 disulfides disulfide NNS cord-274141-vujx538o 574 18 as as IN cord-274141-vujx538o 574 19 novel novel JJ cord-274141-vujx538o 574 20 inhibitors inhibitor NNS cord-274141-vujx538o 574 21 of of IN cord-274141-vujx538o 574 22 SARS SARS NNP cord-274141-vujx538o 574 23 - - HYPH cord-274141-vujx538o 574 24 CoV CoV NNP cord-274141-vujx538o 574 25 main main JJ cord-274141-vujx538o 574 26 protease protease NN cord-274141-vujx538o 574 27 : : : cord-274141-vujx538o 574 28 chemical chemical NN cord-274141-vujx538o 574 29 synthesis synthesis NN cord-274141-vujx538o 574 30 , , , cord-274141-vujx538o 574 31 biological biological JJ cord-274141-vujx538o 574 32 evaluation evaluation NN cord-274141-vujx538o 574 33 , , , cord-274141-vujx538o 574 34 molecular molecular JJ cord-274141-vujx538o 574 35 docking docking NN cord-274141-vujx538o 574 36 and and CC cord-274141-vujx538o 574 37 3D 3d NN cord-274141-vujx538o 574 38 - - HYPH cord-274141-vujx538o 574 39 QSAR QSAR NNP cord-274141-vujx538o 575 1 study study NN cord-274141-vujx538o 575 2 Remdesivir Remdesivir NNP cord-274141-vujx538o 575 3 and and CC cord-274141-vujx538o 575 4 chloroquine chloroquine NN cord-274141-vujx538o 575 5 effectively effectively RB cord-274141-vujx538o 575 6 inhibit inhibit VBP cord-274141-vujx538o 575 7 the the DT cord-274141-vujx538o 575 8 recently recently RB cord-274141-vujx538o 575 9 emerged emerge VBN cord-274141-vujx538o 575 10 novel novel JJ cord-274141-vujx538o 575 11 coronavirus coronavirus NN cord-274141-vujx538o 575 12 ( ( -LRB- cord-274141-vujx538o 575 13 2019-nCoV 2019-ncov CD cord-274141-vujx538o 575 14 ) ) -RRB- cord-274141-vujx538o 575 15 in in IN cord-274141-vujx538o 575 16 vitro vitro FW cord-274141-vujx538o 575 17 Subunit Subunit NNP cord-274141-vujx538o 575 18 vaccines vaccine NNS cord-274141-vujx538o 575 19 against against IN cord-274141-vujx538o 575 20 emerging emerge VBG cord-274141-vujx538o 575 21 pathogenic pathogenic JJ cord-274141-vujx538o 575 22 human human JJ cord-274141-vujx538o 575 23 coronaviruses coronaviruse NNS cord-274141-vujx538o 576 1 A a DT cord-274141-vujx538o 576 2 comparative comparative JJ cord-274141-vujx538o 576 3 study study NN cord-274141-vujx538o 576 4 of of IN cord-274141-vujx538o 576 5 Lonicera Lonicera NNP cord-274141-vujx538o 576 6 japonica japonica NN cord-274141-vujx538o 576 7 with with IN cord-274141-vujx538o 576 8 related relate VBN cord-274141-vujx538o 576 9 species specie NNS cord-274141-vujx538o 576 10 : : : cord-274141-vujx538o 576 11 morphological morphological JJ cord-274141-vujx538o 576 12 characteristics characteristic NNS cord-274141-vujx538o 576 13 , , , cord-274141-vujx538o 576 14 ITS its PRP$ cord-274141-vujx538o 576 15 sequences sequence NNS cord-274141-vujx538o 576 16 and and CC cord-274141-vujx538o 576 17 active active JJ cord-274141-vujx538o 576 18 compounds compound NNS cord-274141-vujx538o 577 1 Specific specific JJ cord-274141-vujx538o 577 2 plant plant NN cord-274141-vujx538o 577 3 terpenoids terpenoid NNS cord-274141-vujx538o 577 4 and and CC cord-274141-vujx538o 577 5 lignoids lignoid NNS cord-274141-vujx538o 577 6 possess possess VBP cord-274141-vujx538o 577 7 potent potent JJ cord-274141-vujx538o 577 8 antiviral antiviral JJ cord-274141-vujx538o 577 9 activities activity NNS cord-274141-vujx538o 577 10 against against IN cord-274141-vujx538o 577 11 severe severe JJ cord-274141-vujx538o 577 12 acute acute JJ cord-274141-vujx538o 577 13 respiratory respiratory JJ cord-274141-vujx538o 577 14 syndrome syndrome NN cord-274141-vujx538o 577 15 coronavirus coronavirus NN cord-274141-vujx538o 577 16 Traditional traditional JJ cord-274141-vujx538o 577 17 Chinese chinese JJ cord-274141-vujx538o 577 18 medicine medicine NN cord-274141-vujx538o 577 19 herbal herbal JJ cord-274141-vujx538o 577 20 extracts extract NNS cord-274141-vujx538o 577 21 of of IN cord-274141-vujx538o 577 22 Cibotium Cibotium NNP cord-274141-vujx538o 577 23 barometz barometz NN cord-274141-vujx538o 577 24 , , , cord-274141-vujx538o 577 25 Gentiana Gentiana NNP cord-274141-vujx538o 577 26 scabra scabra NN cord-274141-vujx538o 577 27 , , , cord-274141-vujx538o 577 28 Dioscorea Dioscorea NNP cord-274141-vujx538o 577 29 batatas batatas NN cord-274141-vujx538o 577 30 , , , cord-274141-vujx538o 577 31 Cassia Cassia NNP cord-274141-vujx538o 577 32 tora tora NNP cord-274141-vujx538o 577 33 , , , cord-274141-vujx538o 577 34 and and CC cord-274141-vujx538o 578 1 Taxillus Taxillus NNP cord-274141-vujx538o 578 2 chinensis chinensis NN cord-274141-vujx538o 578 3 inhibit inhibit VBP cord-274141-vujx538o 578 4 SARS SARS NNP cord-274141-vujx538o 578 5 - - HYPH cord-274141-vujx538o 578 6 CoV CoV NNP cord-274141-vujx538o 578 7 replication replication NN cord-274141-vujx538o 579 1 The the DT cord-274141-vujx538o 579 2 management management NN cord-274141-vujx538o 579 3 of of IN cord-274141-vujx538o 579 4 coronavirus coronavirus NN cord-274141-vujx538o 579 5 infections infection NNS cord-274141-vujx538o 579 6 with with IN cord-274141-vujx538o 579 7 particular particular JJ cord-274141-vujx538o 579 8 reference reference NN cord-274141-vujx538o 579 9 to to IN cord-274141-vujx538o 579 10 SARS SARS NNP cord-274141-vujx538o 579 11 Analysis Analysis NNP cord-274141-vujx538o 579 12 of of IN cord-274141-vujx538o 579 13 therapeutic therapeutic JJ cord-274141-vujx538o 579 14 targets target NNS cord-274141-vujx538o 579 15 for for IN cord-274141-vujx538o 579 16 SARS SARS NNP cord-274141-vujx538o 579 17 - - HYPH cord-274141-vujx538o 579 18 CoV-2 CoV-2 NNP cord-274141-vujx538o 579 19 and and CC cord-274141-vujx538o 579 20 discovery discovery NN cord-274141-vujx538o 579 21 of of IN cord-274141-vujx538o 579 22 potential potential JJ cord-274141-vujx538o 579 23 drugs drug NNS cord-274141-vujx538o 579 24 by by IN cord-274141-vujx538o 579 25 computational computational JJ cord-274141-vujx538o 579 26 methods method NNS cord-274141-vujx538o 579 27 Chemical Chemical NNP cord-274141-vujx538o 579 28 composition composition NN cord-274141-vujx538o 579 29 , , , cord-274141-vujx538o 579 30 antimicrobial antimicrobial JJ cord-274141-vujx538o 579 31 activity activity NN cord-274141-vujx538o 579 32 against against IN cord-274141-vujx538o 579 33 Staphylococcus Staphylococcus NNP cord-274141-vujx538o 579 34 aureus aureus NN cord-274141-vujx538o 579 35 and and CC cord-274141-vujx538o 579 36 a a DT cord-274141-vujx538o 579 37 pro pro JJ cord-274141-vujx538o 579 38 - - JJ cord-274141-vujx538o 579 39 apoptotic apoptotic JJ cord-274141-vujx538o 579 40 effect effect NN cord-274141-vujx538o 579 41 in in IN cord-274141-vujx538o 579 42 SGC-7901 SGC-7901 NNP cord-274141-vujx538o 579 43 of of IN cord-274141-vujx538o 579 44 the the DT cord-274141-vujx538o 579 45 essential essential JJ cord-274141-vujx538o 579 46 oil oil NN cord-274141-vujx538o 579 47 from from IN cord-274141-vujx538o 579 48 Toona Toona NNP cord-274141-vujx538o 579 49 sinensis sinensis NN cord-274141-vujx538o 579 50 ( ( -LRB- cord-274141-vujx538o 579 51 A. A. NNP cord-274141-vujx538o 579 52 Juss Juss NNP cord-274141-vujx538o 579 53 . . . cord-274141-vujx538o 579 54 ) ) -RRB- cord-274141-vujx538o 580 1 Roem Roem NNP cord-274141-vujx538o 580 2 . . . cord-274141-vujx538o 580 3 leaves leave VBZ cord-274141-vujx538o 580 4 Traditional traditional JJ cord-274141-vujx538o 580 5 Chinese chinese JJ cord-274141-vujx538o 580 6 medicine medicine NN cord-274141-vujx538o 580 7 in in IN cord-274141-vujx538o 580 8 the the DT cord-274141-vujx538o 580 9 treatment treatment NN cord-274141-vujx538o 580 10 of of IN cord-274141-vujx538o 580 11 acute acute JJ cord-274141-vujx538o 580 12 respiratory respiratory JJ cord-274141-vujx538o 580 13 tract tract NN cord-274141-vujx538o 580 14 infections infection NNS cord-274141-vujx538o 581 1 The the DT cord-274141-vujx538o 581 2 cardenolide cardenolide NN cord-274141-vujx538o 581 3 ouabain ouabain NN cord-274141-vujx538o 581 4 suppresses suppress VBZ cord-274141-vujx538o 581 5 coronaviral coronaviral JJ cord-274141-vujx538o 581 6 replication replication NN cord-274141-vujx538o 581 7 via via IN cord-274141-vujx538o 581 8 augmenting augment VBG cord-274141-vujx538o 581 9 a a DT cord-274141-vujx538o 581 10 Na+/ na+/ JJ cord-274141-vujx538o 581 11 K+-ATPase k+-atpase NN cord-274141-vujx538o 581 12 - - HYPH cord-274141-vujx538o 581 13 dependent dependent JJ cord-274141-vujx538o 581 14 PI3K_PDK1 PI3K_PDK1 NNP cord-274141-vujx538o 581 15 axis axis NN cord-274141-vujx538o 581 16 signaling signal VBG cord-274141-vujx538o 581 17 Traditional traditional JJ cord-274141-vujx538o 581 18 Chinese chinese JJ cord-274141-vujx538o 581 19 medicine medicine NN cord-274141-vujx538o 581 20 in in IN cord-274141-vujx538o 581 21 the the DT cord-274141-vujx538o 581 22 treatment treatment NN cord-274141-vujx538o 581 23 of of IN cord-274141-vujx538o 581 24 patients patient NNS cord-274141-vujx538o 581 25 infected infect VBN cord-274141-vujx538o 581 26 with with IN cord-274141-vujx538o 581 27 2019-new 2019-new CD cord-274141-vujx538o 581 28 coronavirus coronavirus NN cord-274141-vujx538o 581 29 ( ( -LRB- cord-274141-vujx538o 581 30 SARS SARS NNP cord-274141-vujx538o 581 31 - - HYPH cord-274141-vujx538o 581 32 CoV-2 CoV-2 NNP cord-274141-vujx538o 581 33 ) ) -RRB- cord-274141-vujx538o 581 34 : : : cord-274141-vujx538o 582 1 a a DT cord-274141-vujx538o 582 2 review review NN cord-274141-vujx538o 582 3 and and CC cord-274141-vujx538o 582 4 perspective perspective NN cord-274141-vujx538o 582 5 Water water NN cord-274141-vujx538o 582 6 extract extract NN cord-274141-vujx538o 582 7 of of IN cord-274141-vujx538o 582 8 licorice licorice NN cord-274141-vujx538o 582 9 had have VBD cord-274141-vujx538o 582 10 anti anti JJ cord-274141-vujx538o 582 11 - - JJ cord-274141-vujx538o 582 12 viral viral JJ cord-274141-vujx538o 582 13 activity activity NN cord-274141-vujx538o 582 14 against against IN cord-274141-vujx538o 582 15 human human JJ cord-274141-vujx538o 582 16 respiratory respiratory JJ cord-274141-vujx538o 582 17 syncytial syncytial JJ cord-274141-vujx538o 582 18 virus virus NN cord-274141-vujx538o 582 19 in in IN cord-274141-vujx538o 582 20 human human JJ cord-274141-vujx538o 582 21 respiratory respiratory JJ cord-274141-vujx538o 582 22 tract tract NN cord-274141-vujx538o 582 23 cell cell NN cord-274141-vujx538o 582 24 lines line NNS cord-274141-vujx538o 582 25 Identification Identification NNP cord-274141-vujx538o 582 26 of of IN cord-274141-vujx538o 582 27 myricetin myricetin NNP cord-274141-vujx538o 582 28 and and CC cord-274141-vujx538o 582 29 scutellarein scutellarein NNP cord-274141-vujx538o 582 30 as as IN cord-274141-vujx538o 582 31 novel novel JJ cord-274141-vujx538o 582 32 chemical chemical NN cord-274141-vujx538o 582 33 inhibitors inhibitor NNS cord-274141-vujx538o 582 34 of of IN cord-274141-vujx538o 582 35 the the DT cord-274141-vujx538o 582 36 SARS SARS NNP cord-274141-vujx538o 582 37 coronavirus coronavirus NN cord-274141-vujx538o 582 38 helicase helicase NN cord-274141-vujx538o 582 39 , , , cord-274141-vujx538o 582 40 nsP13 nsP13 NNP cord-274141-vujx538o 583 1 In in IN cord-274141-vujx538o 583 2 silico silico NN cord-274141-vujx538o 583 3 screening screening NN cord-274141-vujx538o 583 4 of of IN cord-274141-vujx538o 583 5 Chinese chinese JJ cord-274141-vujx538o 583 6 herbal herbal JJ cord-274141-vujx538o 583 7 medicines medicine NNS cord-274141-vujx538o 583 8 with with IN cord-274141-vujx538o 583 9 the the DT cord-274141-vujx538o 583 10 potential potential NN cord-274141-vujx538o 583 11 to to TO cord-274141-vujx538o 583 12 directly directly RB cord-274141-vujx538o 583 13 inhibit inhibit VB cord-274141-vujx538o 583 14 2019 2019 CD cord-274141-vujx538o 583 15 novel novel NN cord-274141-vujx538o 583 16 coronavirus coronavirus NN cord-274141-vujx538o 583 17 Association Association NNP cord-274141-vujx538o 583 18 between between IN cord-274141-vujx538o 583 19 mannose mannose NN cord-274141-vujx538o 583 20 - - HYPH cord-274141-vujx538o 583 21 binding bind VBG cord-274141-vujx538o 583 22 lectin lectin NN cord-274141-vujx538o 583 23 gene gene NN cord-274141-vujx538o 583 24 polymorphisms polymorphism NNS cord-274141-vujx538o 583 25 and and CC cord-274141-vujx538o 583 26 susceptibility susceptibility NN cord-274141-vujx538o 583 27 to to IN cord-274141-vujx538o 583 28 severe severe JJ cord-274141-vujx538o 583 29 acute acute JJ cord-274141-vujx538o 583 30 respiratory respiratory JJ cord-274141-vujx538o 583 31 syndrome syndrome NN cord-274141-vujx538o 583 32 coronavirus coronavirus NN cord-274141-vujx538o 583 33 infection infection NN cord-274141-vujx538o 583 34 Astragalus astragalus NN cord-274141-vujx538o 583 35 polysaccharides polysaccharide NNS cord-274141-vujx538o 583 36 inhibit inhibit VBP cord-274141-vujx538o 583 37 avian avian JJ cord-274141-vujx538o 583 38 infectious infectious JJ cord-274141-vujx538o 583 39 bronchitis bronchitis NN cord-274141-vujx538o 583 40 virus virus NN cord-274141-vujx538o 583 41 infection infection NN cord-274141-vujx538o 583 42 by by IN cord-274141-vujx538o 583 43 regulating regulate VBG cord-274141-vujx538o 583 44 viral viral JJ cord-274141-vujx538o 583 45 replication replication NN cord-274141-vujx538o 583 46 Anticomplementary Anticomplementary NNP cord-274141-vujx538o 583 47 principles principle NNS cord-274141-vujx538o 583 48 of of IN cord-274141-vujx538o 583 49 a a DT cord-274141-vujx538o 583 50 Chinese chinese JJ cord-274141-vujx538o 583 51 multiherb multiherb NN cord-274141-vujx538o 583 52 remedy remedy NN cord-274141-vujx538o 583 53 for for IN cord-274141-vujx538o 583 54 the the DT cord-274141-vujx538o 583 55 treatment treatment NN cord-274141-vujx538o 583 56 and and CC cord-274141-vujx538o 583 57 prevention prevention NN cord-274141-vujx538o 583 58 of of IN cord-274141-vujx538o 583 59 SARS SARS NNP cord-274141-vujx538o 583 60 Characterization Characterization NNP cord-274141-vujx538o 583 61 of of IN cord-274141-vujx538o 583 62 the the DT cord-274141-vujx538o 583 63 inhibitory inhibitory JJ cord-274141-vujx538o 583 64 effect effect NN cord-274141-vujx538o 583 65 of of IN cord-274141-vujx538o 583 66 an an DT cord-274141-vujx538o 583 67 extract extract NN cord-274141-vujx538o 583 68 of of IN cord-274141-vujx538o 583 69 Prunella Prunella NNP cord-274141-vujx538o 583 70 vulgaris vulgaris NN cord-274141-vujx538o 583 71 on on IN cord-274141-vujx538o 583 72 Ebola Ebola NNP cord-274141-vujx538o 583 73 virus virus NN cord-274141-vujx538o 583 74 glycoprotein glycoprotein NN cord-274141-vujx538o 583 75 ( ( -LRB- cord-274141-vujx538o 583 76 GP)-mediated gp)-mediated CD cord-274141-vujx538o 583 77 virus virus NN cord-274141-vujx538o 583 78 entry entry NN cord-274141-vujx538o 583 79 and and CC cord-274141-vujx538o 583 80 infection infection NN cord-274141-vujx538o 583 81 Complete complete JJ cord-274141-vujx538o 583 82 genomic genomic JJ cord-274141-vujx538o 583 83 sequences sequence NNS cord-274141-vujx538o 583 84 , , , cord-274141-vujx538o 583 85 a a DT cord-274141-vujx538o 583 86 key key JJ cord-274141-vujx538o 583 87 residue residue NN cord-274141-vujx538o 583 88 in in IN cord-274141-vujx538o 583 89 the the DT cord-274141-vujx538o 583 90 spike spike NN cord-274141-vujx538o 583 91 protein protein NN cord-274141-vujx538o 583 92 and and CC cord-274141-vujx538o 583 93 deletions deletion NNS cord-274141-vujx538o 583 94 in in IN cord-274141-vujx538o 583 95 nonstructural nonstructural JJ cord-274141-vujx538o 583 96 protein protein NN cord-274141-vujx538o 583 97 3b 3b CD cord-274141-vujx538o 583 98 of of IN cord-274141-vujx538o 583 99 US US NNP cord-274141-vujx538o 583 100 strains strain NNS cord-274141-vujx538o 583 101 of of IN cord-274141-vujx538o 583 102 the the DT cord-274141-vujx538o 583 103 virulent virulent JJ cord-274141-vujx538o 583 104 and and CC cord-274141-vujx538o 583 105 attenuated attenuated JJ cord-274141-vujx538o 583 106 coronaviruses coronaviruse NNS cord-274141-vujx538o 583 107 , , , cord-274141-vujx538o 583 108 transmissible transmissible JJ cord-274141-vujx538o 583 109 gastroenteritis gastroenteritis NN cord-274141-vujx538o 583 110 virus virus NN cord-274141-vujx538o 583 111 and and CC cord-274141-vujx538o 583 112 porcine porcine JJ cord-274141-vujx538o 583 113 respiratory respiratory JJ cord-274141-vujx538o 583 114 coronavirus coronavirus NN cord-274141-vujx538o 583 115 Antiviral antiviral JJ cord-274141-vujx538o 583 116 activity activity NN cord-274141-vujx538o 583 117 of of IN cord-274141-vujx538o 583 118 Jinchai Jinchai NNP cord-274141-vujx538o 583 119 capsule capsule NN cord-274141-vujx538o 583 120 against against IN cord-274141-vujx538o 583 121 influenza influenza NN cord-274141-vujx538o 583 122 virus virus NN cord-274141-vujx538o 583 123 Glycopeptide Glycopeptide NNP cord-274141-vujx538o 583 124 antibiotics antibiotic NNS cord-274141-vujx538o 583 125 potently potently RB cord-274141-vujx538o 583 126 inhibit inhibit VBP cord-274141-vujx538o 583 127 cathepsin cathepsin NN cord-274141-vujx538o 583 128 L l NN cord-274141-vujx538o 583 129 in in IN cord-274141-vujx538o 583 130 the the DT cord-274141-vujx538o 583 131 late late JJ cord-274141-vujx538o 583 132 endosome endosome NN cord-274141-vujx538o 583 133 / / SYM cord-274141-vujx538o 583 134 lysosome lysosome NN cord-274141-vujx538o 583 135 and and CC cord-274141-vujx538o 583 136 block block VB cord-274141-vujx538o 583 137 the the DT cord-274141-vujx538o 583 138 entry entry NN cord-274141-vujx538o 583 139 of of IN cord-274141-vujx538o 583 140 Ebola Ebola NNP cord-274141-vujx538o 583 141 virus virus NN cord-274141-vujx538o 583 142 , , , cord-274141-vujx538o 583 143 Middle Middle NNP cord-274141-vujx538o 583 144 East East NNP cord-274141-vujx538o 583 145 respiratory respiratory JJ cord-274141-vujx538o 583 146 syndrome syndrome NN cord-274141-vujx538o 583 147 coronavirus coronavirus NN cord-274141-vujx538o 583 148 ( ( -LRB- cord-274141-vujx538o 583 149 MERS MERS NNP cord-274141-vujx538o 583 150 - - HYPH cord-274141-vujx538o 583 151 CoV CoV NNP cord-274141-vujx538o 583 152 ) ) -RRB- cord-274141-vujx538o 583 153 , , , cord-274141-vujx538o 583 154 and and CC cord-274141-vujx538o 583 155 severe severe JJ cord-274141-vujx538o 583 156 acute acute JJ cord-274141-vujx538o 583 157 respiratory respiratory JJ cord-274141-vujx538o 583 158 syndrome syndrome NN cord-274141-vujx538o 583 159 coronavirus coronavirus NN cord-274141-vujx538o 583 160 ( ( -LRB- cord-274141-vujx538o 583 161 SARS SARS NNP cord-274141-vujx538o 583 162 - - HYPH cord-274141-vujx538o 583 163 CoV CoV NNP cord-274141-vujx538o 583 164 ) ) -RRB- cord-274141-vujx538o 584 1 A a DT cord-274141-vujx538o 584 2 pneumonia pneumonia NN cord-274141-vujx538o 584 3 outbreak outbreak NN cord-274141-vujx538o 584 4 associated associate VBN cord-274141-vujx538o 584 5 with with IN cord-274141-vujx538o 584 6 a a DT cord-274141-vujx538o 584 7 new new JJ cord-274141-vujx538o 584 8 coronavirus coronavirus NN cord-274141-vujx538o 584 9 of of IN cord-274141-vujx538o 584 10 probable probable JJ cord-274141-vujx538o 584 11 bat bat NN cord-274141-vujx538o 584 12 origin origin NN cord-274141-vujx538o 584 13 Inhibitors Inhibitors NNP cord-274141-vujx538o 584 14 of of IN cord-274141-vujx538o 584 15 SARS SARS NNP cord-274141-vujx538o 584 16 - - HYPH cord-274141-vujx538o 584 17 CoV CoV NNP cord-274141-vujx538o 584 18 entry entry NN cord-274141-vujx538o 584 19 - - HYPH cord-274141-vujx538o 584 20 identification identification NN cord-274141-vujx538o 584 21 using use VBG cord-274141-vujx538o 584 22 an an DT cord-274141-vujx538o 584 23 internally internally RB cord-274141-vujx538o 584 24 - - HYPH cord-274141-vujx538o 584 25 controlled control VBN cord-274141-vujx538o 584 26 dual dual JJ cord-274141-vujx538o 584 27 envelope envelope NN cord-274141-vujx538o 584 28 pseudovirion pseudovirion NN cord-274141-vujx538o 584 29 assay assay NN cord-274141-vujx538o 584 30 Networkbased Networkbased NNP cord-274141-vujx538o 584 31 drug drug NN cord-274141-vujx538o 584 32 repurposing repurpose VBG cord-274141-vujx538o 584 33 for for IN cord-274141-vujx538o 584 34 novel novel JJ cord-274141-vujx538o 584 35 coronavirus coronavirus NN cord-274141-vujx538o 584 36 2019-nCoV 2019-ncov CD cord-274141-vujx538o 584 37 / / SYM cord-274141-vujx538o 584 38 SARS SARS NNP cord-274141-vujx538o 584 39 - - HYPH cord-274141-vujx538o 584 40 CoV-2 CoV-2 NNP cord-274141-vujx538o 585 1 A a DT cord-274141-vujx538o 585 2 single single JJ cord-274141-vujx538o 585 3 asparagine asparagine NN cord-274141-vujx538o 585 4 - - HYPH cord-274141-vujx538o 585 5 linked link VBN cord-274141-vujx538o 585 6 glycosylation glycosylation NN cord-274141-vujx538o 585 7 site site NN cord-274141-vujx538o 585 8 of of IN cord-274141-vujx538o 585 9 the the DT cord-274141-vujx538o 585 10 severe severe JJ cord-274141-vujx538o 585 11 acute acute JJ cord-274141-vujx538o 585 12 respiratory respiratory JJ cord-274141-vujx538o 585 13 syndrome syndrome NN cord-274141-vujx538o 585 14 coronavirus coronavirus NN cord-274141-vujx538o 585 15 spike spike NN cord-274141-vujx538o 585 16 glycoprotein glycoprotein NN cord-274141-vujx538o 585 17 facilitates facilitate VBZ cord-274141-vujx538o 585 18 inhibition inhibition NN cord-274141-vujx538o 585 19 by by IN cord-274141-vujx538o 585 20 mannose mannose NN cord-274141-vujx538o 585 21 - - HYPH cord-274141-vujx538o 585 22 binding bind VBG cord-274141-vujx538o 585 23 lectin lectin NN cord-274141-vujx538o 585 24 through through IN cord-274141-vujx538o 585 25 multiple multiple JJ cord-274141-vujx538o 585 26 mechanisms mechanism NNS cord-274141-vujx538o 585 27 Chinese chinese JJ cord-274141-vujx538o 585 28 patent patent NN cord-274141-vujx538o 585 29 medicines medicine NNS cord-274141-vujx538o 585 30 in in IN cord-274141-vujx538o 585 31 the the DT cord-274141-vujx538o 585 32 treatment treatment NN cord-274141-vujx538o 585 33 of of IN cord-274141-vujx538o 585 34 coronavirus coronavirus NN cord-274141-vujx538o 585 35 disease disease NN cord-274141-vujx538o 585 36 2019 2019 CD cord-274141-vujx538o 585 37 ( ( -LRB- cord-274141-vujx538o 585 38 COVID-19 COVID-19 NNP cord-274141-vujx538o 585 39 ) ) -RRB- cord-274141-vujx538o 585 40 in in IN cord-274141-vujx538o 586 1 China China NNP cord-274141-vujx538o 586 2 Procyanidins Procyanidins NNP cord-274141-vujx538o 586 3 and and CC cord-274141-vujx538o 586 4 butanol butanol NN cord-274141-vujx538o 586 5 extract extract NN cord-274141-vujx538o 586 6 of of IN cord-274141-vujx538o 586 7 cinnamomi cinnamomi NNP cord-274141-vujx538o 586 8 cortex cortex NNP cord-274141-vujx538o 586 9 inhibit inhibit VBP cord-274141-vujx538o 586 10 SARS SARS NNP cord-274141-vujx538o 586 11 - - HYPH cord-274141-vujx538o 586 12 CoV cov NN cord-274141-vujx538o 586 13 infection infection NN cord-274141-vujx538o 586 14 Acknowledgments acknowledgment NNS cord-274141-vujx538o 587 1 The the DT cord-274141-vujx538o 587 2 author author NN cord-274141-vujx538o 587 3 is be VBZ cord-274141-vujx538o 587 4 grateful grateful JJ cord-274141-vujx538o 587 5 to to IN cord-274141-vujx538o 587 6 the the DT cord-274141-vujx538o 587 7 anonymous anonymous JJ cord-274141-vujx538o 587 8 reviewers reviewer NNS cord-274141-vujx538o 587 9 and and CC cord-274141-vujx538o 587 10 to to IN cord-274141-vujx538o 587 11 Professor Professor NNP cord-274141-vujx538o 587 12 Rogelio Rogelio NNP cord-274141-vujx538o 587 13 Pereda Pereda NNP cord-274141-vujx538o 587 14 - - HYPH cord-274141-vujx538o 587 15 Miranda Miranda NNP cord-274141-vujx538o 587 16 , , , cord-274141-vujx538o 587 17 Editor editor NN cord-274141-vujx538o 587 18 - - HYPH cord-274141-vujx538o 587 19 in in IN cord-274141-vujx538o 587 20 - - HYPH cord-274141-vujx538o 587 21 Chief chief NN cord-274141-vujx538o 587 22 of of IN cord-274141-vujx538o 587 23 Revista Revista NNP cord-274141-vujx538o 587 24 Brasileira Brasileira NNP cord-274141-vujx538o 587 25 de de NNP cord-274141-vujx538o 587 26 Farmacognosia Farmacognosia NNP cord-274141-vujx538o 587 27 , , , cord-274141-vujx538o 587 28 for for IN cord-274141-vujx538o 587 29 their -PRON- PRP$ cord-274141-vujx538o 587 30 help help NN cord-274141-vujx538o 587 31 in in IN cord-274141-vujx538o 587 32 improving improve VBG cord-274141-vujx538o 587 33 the the DT cord-274141-vujx538o 587 34 original original JJ cord-274141-vujx538o 587 35 manuscript manuscript NN cord-274141-vujx538o 587 36 . . .