id sid tid token lemma pos cord-273505-pcsw3vmx 1 1 key key JJ cord-273505-pcsw3vmx 2 1 : : : cord-273505-pcsw3vmx 2 2 cord-273505-pcsw3vmx cord-273505-pcsw3vmx NN cord-273505-pcsw3vmx 2 3 authors author NNS cord-273505-pcsw3vmx 2 4 : : : cord-273505-pcsw3vmx 2 5 Liu Liu NNP cord-273505-pcsw3vmx 2 6 , , , cord-273505-pcsw3vmx 2 7 Xiaosheng Xiaosheng NNP cord-273505-pcsw3vmx 2 8 ; ; : cord-273505-pcsw3vmx 2 9 Cao Cao NNP cord-273505-pcsw3vmx 2 10 , , , cord-273505-pcsw3vmx 2 11 Wei Wei NNP cord-273505-pcsw3vmx 2 12 ; ; : cord-273505-pcsw3vmx 2 13 Li Li NNP cord-273505-pcsw3vmx 2 14 , , , cord-273505-pcsw3vmx 3 1 Taisheng Taisheng NNP cord-273505-pcsw3vmx 3 2 title title NN cord-273505-pcsw3vmx 3 3 : : : cord-273505-pcsw3vmx 3 4 High high JJ cord-273505-pcsw3vmx 3 5 - - HYPH cord-273505-pcsw3vmx 3 6 Dose dose NN cord-273505-pcsw3vmx 3 7 Intravenous Intravenous NNP cord-273505-pcsw3vmx 3 8 Immunoglobulins Immunoglobulins NNP cord-273505-pcsw3vmx 3 9 in in IN cord-273505-pcsw3vmx 3 10 the the DT cord-273505-pcsw3vmx 3 11 Treatment Treatment NNP cord-273505-pcsw3vmx 3 12 of of IN cord-273505-pcsw3vmx 3 13 Severe severe JJ cord-273505-pcsw3vmx 3 14 Acute acute JJ cord-273505-pcsw3vmx 3 15 Viral viral JJ cord-273505-pcsw3vmx 3 16 Pneumonia pneumonia NN cord-273505-pcsw3vmx 3 17 : : : cord-273505-pcsw3vmx 4 1 The the DT cord-273505-pcsw3vmx 4 2 Known Known NNP cord-273505-pcsw3vmx 4 3 Mechanisms Mechanisms NNPS cord-273505-pcsw3vmx 4 4 and and CC cord-273505-pcsw3vmx 4 5 Clinical clinical JJ cord-273505-pcsw3vmx 4 6 Effects effect NNS cord-273505-pcsw3vmx 4 7 date date NN cord-273505-pcsw3vmx 4 8 : : : cord-273505-pcsw3vmx 4 9 2020 2020 CD cord-273505-pcsw3vmx 4 10 - - HYPH cord-273505-pcsw3vmx 4 11 07 07 CD cord-273505-pcsw3vmx 4 12 - - SYM cord-273505-pcsw3vmx 4 13 14 14 CD cord-273505-pcsw3vmx 4 14 journal journal NN cord-273505-pcsw3vmx 4 15 : : : cord-273505-pcsw3vmx 5 1 Front Front NNP cord-273505-pcsw3vmx 5 2 Immunol Immunol NNP cord-273505-pcsw3vmx 5 3 DOI doi NN cord-273505-pcsw3vmx 5 4 : : : cord-273505-pcsw3vmx 6 1 10.3389/ 10.3389/ CD cord-273505-pcsw3vmx 7 1 fimmu.2020.01660 fimmu.2020.01660 CD cord-273505-pcsw3vmx 7 2 sha sha NNP cord-273505-pcsw3vmx 7 3 : : : cord-273505-pcsw3vmx 8 1 19a425b10c474b22402d5668b661bf76a4406aee 19a425b10c474b22402d5668b661bf76a4406aee CD cord-273505-pcsw3vmx 8 2 doc_id doc_id CD cord-273505-pcsw3vmx 8 3 : : : cord-273505-pcsw3vmx 8 4 273505 273505 CD cord-273505-pcsw3vmx 8 5 cord_uid cord_uid NNS cord-273505-pcsw3vmx 8 6 : : : cord-273505-pcsw3vmx 9 1 pcsw3vmx pcsw3vmx NN cord-273505-pcsw3vmx 10 1 The the DT cord-273505-pcsw3vmx 10 2 current current JJ cord-273505-pcsw3vmx 10 3 outbreak outbreak NN cord-273505-pcsw3vmx 10 4 of of IN cord-273505-pcsw3vmx 10 5 viral viral JJ cord-273505-pcsw3vmx 10 6 pneumonia pneumonia NN cord-273505-pcsw3vmx 10 7 , , , cord-273505-pcsw3vmx 10 8 caused cause VBN cord-273505-pcsw3vmx 10 9 by by IN cord-273505-pcsw3vmx 10 10 novel novel JJ cord-273505-pcsw3vmx 10 11 coronavirus coronavirus NN cord-273505-pcsw3vmx 10 12 SARS SARS NNP cord-273505-pcsw3vmx 10 13 - - HYPH cord-273505-pcsw3vmx 10 14 CoV-2 CoV-2 NNP cord-273505-pcsw3vmx 10 15 , , , cord-273505-pcsw3vmx 10 16 is be VBZ cord-273505-pcsw3vmx 10 17 the the DT cord-273505-pcsw3vmx 10 18 focus focus NN cord-273505-pcsw3vmx 10 19 of of IN cord-273505-pcsw3vmx 10 20 worldwide worldwide JJ cord-273505-pcsw3vmx 10 21 attention attention NN cord-273505-pcsw3vmx 10 22 . . . cord-273505-pcsw3vmx 11 1 The the DT cord-273505-pcsw3vmx 11 2 WHO who WP cord-273505-pcsw3vmx 11 3 declared declare VBD cord-273505-pcsw3vmx 11 4 the the DT cord-273505-pcsw3vmx 11 5 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 11 6 outbreak outbreak NN cord-273505-pcsw3vmx 11 7 a a DT cord-273505-pcsw3vmx 11 8 pandemic pandemic NN cord-273505-pcsw3vmx 11 9 event event NN cord-273505-pcsw3vmx 11 10 on on IN cord-273505-pcsw3vmx 11 11 Mar Mar NNP cord-273505-pcsw3vmx 11 12 12 12 CD cord-273505-pcsw3vmx 11 13 , , , cord-273505-pcsw3vmx 11 14 2020 2020 CD cord-273505-pcsw3vmx 11 15 , , , cord-273505-pcsw3vmx 11 16 and and CC cord-273505-pcsw3vmx 11 17 the the DT cord-273505-pcsw3vmx 11 18 number number NN cord-273505-pcsw3vmx 11 19 of of IN cord-273505-pcsw3vmx 11 20 confirmed confirm VBN cord-273505-pcsw3vmx 11 21 cases case NNS cord-273505-pcsw3vmx 11 22 is be VBZ cord-273505-pcsw3vmx 11 23 still still RB cord-273505-pcsw3vmx 11 24 on on IN cord-273505-pcsw3vmx 11 25 the the DT cord-273505-pcsw3vmx 11 26 rise rise NN cord-273505-pcsw3vmx 11 27 worldwide worldwide RB cord-273505-pcsw3vmx 11 28 . . . cord-273505-pcsw3vmx 12 1 While while IN cord-273505-pcsw3vmx 12 2 most most RBS cord-273505-pcsw3vmx 12 3 infected infected JJ cord-273505-pcsw3vmx 12 4 individuals individual NNS cord-273505-pcsw3vmx 12 5 only only RB cord-273505-pcsw3vmx 12 6 experience experience VBP cord-273505-pcsw3vmx 12 7 mild mild JJ cord-273505-pcsw3vmx 12 8 symptoms symptom NNS cord-273505-pcsw3vmx 12 9 or or CC cord-273505-pcsw3vmx 12 10 may may MD cord-273505-pcsw3vmx 12 11 even even RB cord-273505-pcsw3vmx 12 12 be be VB cord-273505-pcsw3vmx 12 13 asymptomatic asymptomatic JJ cord-273505-pcsw3vmx 12 14 , , , cord-273505-pcsw3vmx 12 15 some some DT cord-273505-pcsw3vmx 12 16 patients patient NNS cord-273505-pcsw3vmx 12 17 rapidly rapidly RB cord-273505-pcsw3vmx 12 18 progress progress VBP cord-273505-pcsw3vmx 12 19 to to IN cord-273505-pcsw3vmx 12 20 severe severe JJ cord-273505-pcsw3vmx 12 21 acute acute JJ cord-273505-pcsw3vmx 12 22 respiratory respiratory JJ cord-273505-pcsw3vmx 12 23 failure failure NN cord-273505-pcsw3vmx 12 24 with with IN cord-273505-pcsw3vmx 12 25 substantial substantial JJ cord-273505-pcsw3vmx 12 26 mortality mortality NN cord-273505-pcsw3vmx 12 27 , , , cord-273505-pcsw3vmx 12 28 making make VBG cord-273505-pcsw3vmx 12 29 it -PRON- PRP cord-273505-pcsw3vmx 12 30 imperative imperative JJ cord-273505-pcsw3vmx 12 31 to to TO cord-273505-pcsw3vmx 12 32 develop develop VB cord-273505-pcsw3vmx 12 33 an an DT cord-273505-pcsw3vmx 12 34 efficient efficient JJ cord-273505-pcsw3vmx 12 35 treatment treatment NN cord-273505-pcsw3vmx 12 36 for for IN cord-273505-pcsw3vmx 12 37 severe severe JJ cord-273505-pcsw3vmx 12 38 SARS SARS NNP cord-273505-pcsw3vmx 12 39 - - HYPH cord-273505-pcsw3vmx 12 40 CoV-2 CoV-2 NNP cord-273505-pcsw3vmx 12 41 pneumonia pneumonia NN cord-273505-pcsw3vmx 12 42 alongside alongside IN cord-273505-pcsw3vmx 12 43 supportive supportive JJ cord-273505-pcsw3vmx 12 44 care care NN cord-273505-pcsw3vmx 12 45 . . . cord-273505-pcsw3vmx 13 1 So so RB cord-273505-pcsw3vmx 13 2 far far RB cord-273505-pcsw3vmx 13 3 , , , cord-273505-pcsw3vmx 13 4 the the DT cord-273505-pcsw3vmx 13 5 optimal optimal JJ cord-273505-pcsw3vmx 13 6 treatment treatment NN cord-273505-pcsw3vmx 13 7 strategy strategy NN cord-273505-pcsw3vmx 13 8 for for IN cord-273505-pcsw3vmx 13 9 severe severe JJ cord-273505-pcsw3vmx 13 10 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 13 11 remains remain VBZ cord-273505-pcsw3vmx 13 12 unknown unknown JJ cord-273505-pcsw3vmx 13 13 . . . cord-273505-pcsw3vmx 14 1 Intravenous intravenous JJ cord-273505-pcsw3vmx 14 2 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 14 3 ( ( -LRB- cord-273505-pcsw3vmx 14 4 IVIg IVIg NNP cord-273505-pcsw3vmx 14 5 ) ) -RRB- cord-273505-pcsw3vmx 14 6 is be VBZ cord-273505-pcsw3vmx 14 7 a a DT cord-273505-pcsw3vmx 14 8 blood blood NN cord-273505-pcsw3vmx 14 9 product product NN cord-273505-pcsw3vmx 14 10 pooled pool VBN cord-273505-pcsw3vmx 14 11 from from IN cord-273505-pcsw3vmx 14 12 healthy healthy JJ cord-273505-pcsw3vmx 14 13 donors donor NNS cord-273505-pcsw3vmx 14 14 with with IN cord-273505-pcsw3vmx 14 15 high high JJ cord-273505-pcsw3vmx 14 16 concentrations concentration NNS cord-273505-pcsw3vmx 14 17 of of IN cord-273505-pcsw3vmx 14 18 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 14 19 G G NNP cord-273505-pcsw3vmx 14 20 ( ( -LRB- cord-273505-pcsw3vmx 14 21 IgG IgG NNP cord-273505-pcsw3vmx 14 22 ) ) -RRB- cord-273505-pcsw3vmx 14 23 and and CC cord-273505-pcsw3vmx 14 24 has have VBZ cord-273505-pcsw3vmx 14 25 been be VBN cord-273505-pcsw3vmx 14 26 used use VBN cord-273505-pcsw3vmx 14 27 in in IN cord-273505-pcsw3vmx 14 28 patients patient NNS cord-273505-pcsw3vmx 14 29 with with IN cord-273505-pcsw3vmx 14 30 autoimmune autoimmune JJ cord-273505-pcsw3vmx 14 31 and and CC cord-273505-pcsw3vmx 14 32 inflammatory inflammatory JJ cord-273505-pcsw3vmx 14 33 diseases disease NNS cord-273505-pcsw3vmx 14 34 for for IN cord-273505-pcsw3vmx 14 35 more more JJR cord-273505-pcsw3vmx 14 36 than than IN cord-273505-pcsw3vmx 14 37 30 30 CD cord-273505-pcsw3vmx 14 38 years year NNS cord-273505-pcsw3vmx 14 39 . . . cord-273505-pcsw3vmx 15 1 In in IN cord-273505-pcsw3vmx 15 2 this this DT cord-273505-pcsw3vmx 15 3 review review NN cord-273505-pcsw3vmx 15 4 , , , cord-273505-pcsw3vmx 15 5 we -PRON- PRP cord-273505-pcsw3vmx 15 6 aim aim VBP cord-273505-pcsw3vmx 15 7 to to TO cord-273505-pcsw3vmx 15 8 highlight highlight VB cord-273505-pcsw3vmx 15 9 the the DT cord-273505-pcsw3vmx 15 10 known know VBN cord-273505-pcsw3vmx 15 11 mechanisms mechanism NNS cord-273505-pcsw3vmx 15 12 of of IN cord-273505-pcsw3vmx 15 13 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 15 14 effects effect NNS cord-273505-pcsw3vmx 15 15 of of IN cord-273505-pcsw3vmx 15 16 high high JJ cord-273505-pcsw3vmx 15 17 - - HYPH cord-273505-pcsw3vmx 15 18 dose dose NN cord-273505-pcsw3vmx 15 19 IVIg ivig NN cord-273505-pcsw3vmx 15 20 therapy therapy NN cord-273505-pcsw3vmx 15 21 , , , cord-273505-pcsw3vmx 15 22 the the DT cord-273505-pcsw3vmx 15 23 immunopathological immunopathological JJ cord-273505-pcsw3vmx 15 24 hypothesis hypothesis NN cord-273505-pcsw3vmx 15 25 of of IN cord-273505-pcsw3vmx 15 26 viral viral JJ cord-273505-pcsw3vmx 15 27 pneumonia pneumonia NN cord-273505-pcsw3vmx 15 28 , , , cord-273505-pcsw3vmx 15 29 and and CC cord-273505-pcsw3vmx 15 30 the the DT cord-273505-pcsw3vmx 15 31 clinical clinical JJ cord-273505-pcsw3vmx 15 32 evidence evidence NN cord-273505-pcsw3vmx 15 33 of of IN cord-273505-pcsw3vmx 15 34 IVIg ivig JJ cord-273505-pcsw3vmx 15 35 therapy therapy NN cord-273505-pcsw3vmx 15 36 in in IN cord-273505-pcsw3vmx 15 37 viral viral JJ cord-273505-pcsw3vmx 15 38 pneumonia pneumonia NN cord-273505-pcsw3vmx 15 39 . . . cord-273505-pcsw3vmx 16 1 We -PRON- PRP cord-273505-pcsw3vmx 16 2 then then RB cord-273505-pcsw3vmx 16 3 make make VBP cord-273505-pcsw3vmx 16 4 cautious cautious JJ cord-273505-pcsw3vmx 16 5 therapeutic therapeutic JJ cord-273505-pcsw3vmx 16 6 inferences inference NNS cord-273505-pcsw3vmx 16 7 about about IN cord-273505-pcsw3vmx 16 8 high high JJ cord-273505-pcsw3vmx 16 9 - - HYPH cord-273505-pcsw3vmx 16 10 dose dose NN cord-273505-pcsw3vmx 16 11 IVIg ivig NN cord-273505-pcsw3vmx 16 12 therapy therapy NN cord-273505-pcsw3vmx 16 13 in in IN cord-273505-pcsw3vmx 16 14 treating treat VBG cord-273505-pcsw3vmx 16 15 severe severe JJ cord-273505-pcsw3vmx 16 16 COVID-19 covid-19 NN cord-273505-pcsw3vmx 16 17 . . . cord-273505-pcsw3vmx 17 1 These these DT cord-273505-pcsw3vmx 17 2 inferences inference NNS cord-273505-pcsw3vmx 17 3 may may MD cord-273505-pcsw3vmx 17 4 provide provide VB cord-273505-pcsw3vmx 17 5 relevant relevant JJ cord-273505-pcsw3vmx 17 6 and and CC cord-273505-pcsw3vmx 17 7 useful useful JJ cord-273505-pcsw3vmx 17 8 insights insight NNS cord-273505-pcsw3vmx 17 9 in in IN cord-273505-pcsw3vmx 17 10 order order NN cord-273505-pcsw3vmx 17 11 to to TO cord-273505-pcsw3vmx 17 12 aid aid VB cord-273505-pcsw3vmx 17 13 treatment treatment NN cord-273505-pcsw3vmx 17 14 for for IN cord-273505-pcsw3vmx 17 15 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 17 16 . . . cord-273505-pcsw3vmx 18 1 Recently recently RB cord-273505-pcsw3vmx 18 2 , , , cord-273505-pcsw3vmx 18 3 the the DT cord-273505-pcsw3vmx 18 4 outbreak outbreak NN cord-273505-pcsw3vmx 18 5 of of IN cord-273505-pcsw3vmx 18 6 a a DT cord-273505-pcsw3vmx 18 7 febrile febrile JJ cord-273505-pcsw3vmx 18 8 respiratory respiratory JJ cord-273505-pcsw3vmx 18 9 disease disease NN cord-273505-pcsw3vmx 18 10 caused cause VBN cord-273505-pcsw3vmx 18 11 by by IN cord-273505-pcsw3vmx 18 12 a a DT cord-273505-pcsw3vmx 18 13 novel novel JJ cord-273505-pcsw3vmx 18 14 beta beta NN cord-273505-pcsw3vmx 18 15 - - HYPH cord-273505-pcsw3vmx 18 16 coronavirus coronavirus NN cord-273505-pcsw3vmx 18 17 , , , cord-273505-pcsw3vmx 18 18 designated designate VBN cord-273505-pcsw3vmx 18 19 SARS SARS NNP cord-273505-pcsw3vmx 18 20 - - HYPH cord-273505-pcsw3vmx 18 21 CoV-2 CoV-2 NNP cord-273505-pcsw3vmx 18 22 , , , cord-273505-pcsw3vmx 18 23 has have VBZ cord-273505-pcsw3vmx 18 24 become become VBN cord-273505-pcsw3vmx 18 25 the the DT cord-273505-pcsw3vmx 18 26 focus focus NN cord-273505-pcsw3vmx 18 27 of of IN cord-273505-pcsw3vmx 18 28 worldwide worldwide JJ cord-273505-pcsw3vmx 18 29 attention attention NN cord-273505-pcsw3vmx 18 30 . . . cord-273505-pcsw3vmx 19 1 The the DT cord-273505-pcsw3vmx 19 2 event event NN cord-273505-pcsw3vmx 19 3 was be VBD cord-273505-pcsw3vmx 19 4 declared declare VBN cord-273505-pcsw3vmx 19 5 a a DT cord-273505-pcsw3vmx 19 6 Pandemic pandemic NN cord-273505-pcsw3vmx 19 7 by by IN cord-273505-pcsw3vmx 19 8 the the DT cord-273505-pcsw3vmx 19 9 WHO WHO NNP cord-273505-pcsw3vmx 19 10 on on IN cord-273505-pcsw3vmx 19 11 Mar Mar NNP cord-273505-pcsw3vmx 19 12 12 12 CD cord-273505-pcsw3vmx 19 13 , , , cord-273505-pcsw3vmx 19 14 2020 2020 CD cord-273505-pcsw3vmx 19 15 , , , cord-273505-pcsw3vmx 19 16 and and CC cord-273505-pcsw3vmx 19 17 the the DT cord-273505-pcsw3vmx 19 18 number number NN cord-273505-pcsw3vmx 19 19 of of IN cord-273505-pcsw3vmx 19 20 confirmed confirm VBN cord-273505-pcsw3vmx 19 21 cases case NNS cord-273505-pcsw3vmx 19 22 is be VBZ cord-273505-pcsw3vmx 19 23 still still RB cord-273505-pcsw3vmx 19 24 climbing climb VBG cord-273505-pcsw3vmx 19 25 worldwide worldwide RB cord-273505-pcsw3vmx 19 26 . . . cord-273505-pcsw3vmx 20 1 Typical typical JJ cord-273505-pcsw3vmx 20 2 clinical clinical JJ cord-273505-pcsw3vmx 20 3 features feature NNS cord-273505-pcsw3vmx 20 4 of of IN cord-273505-pcsw3vmx 20 5 COVID-19 covid-19 DT cord-273505-pcsw3vmx 20 6 include include VBP cord-273505-pcsw3vmx 20 7 fever fever NN cord-273505-pcsw3vmx 20 8 , , , cord-273505-pcsw3vmx 20 9 respiratory respiratory JJ cord-273505-pcsw3vmx 20 10 symptoms symptom NNS cord-273505-pcsw3vmx 20 11 such such JJ cord-273505-pcsw3vmx 20 12 as as IN cord-273505-pcsw3vmx 20 13 dry dry JJ cord-273505-pcsw3vmx 20 14 cough cough NN cord-273505-pcsw3vmx 20 15 and and CC cord-273505-pcsw3vmx 20 16 shortness shortness NN cord-273505-pcsw3vmx 20 17 of of IN cord-273505-pcsw3vmx 20 18 breath breath NN cord-273505-pcsw3vmx 20 19 , , , cord-273505-pcsw3vmx 20 20 and and CC cord-273505-pcsw3vmx 20 21 fatigue fatigue NN cord-273505-pcsw3vmx 20 22 ( ( -LRB- cord-273505-pcsw3vmx 20 23 1 1 CD cord-273505-pcsw3vmx 20 24 ) ) -RRB- cord-273505-pcsw3vmx 20 25 . . . cord-273505-pcsw3vmx 21 1 While while IN cord-273505-pcsw3vmx 21 2 the the DT cord-273505-pcsw3vmx 21 3 majority majority NN cord-273505-pcsw3vmx 21 4 of of IN cord-273505-pcsw3vmx 21 5 infected infected JJ cord-273505-pcsw3vmx 21 6 individuals individual NNS cord-273505-pcsw3vmx 21 7 experience experience VBP cord-273505-pcsw3vmx 21 8 only only RB cord-273505-pcsw3vmx 21 9 mild mild JJ cord-273505-pcsw3vmx 21 10 symptoms symptom NNS cord-273505-pcsw3vmx 21 11 or or CC cord-273505-pcsw3vmx 21 12 may may MD cord-273505-pcsw3vmx 21 13 even even RB cord-273505-pcsw3vmx 21 14 be be VB cord-273505-pcsw3vmx 21 15 asymptomatic asymptomatic JJ cord-273505-pcsw3vmx 21 16 , , , cord-273505-pcsw3vmx 21 17 about about RB cord-273505-pcsw3vmx 21 18 10 10 CD cord-273505-pcsw3vmx 21 19 to to TO cord-273505-pcsw3vmx 21 20 20 20 CD cord-273505-pcsw3vmx 21 21 % % NN cord-273505-pcsw3vmx 21 22 of of IN cord-273505-pcsw3vmx 21 23 patients patient NNS cord-273505-pcsw3vmx 21 24 rapidly rapidly RB cord-273505-pcsw3vmx 21 25 progress progress VBP cord-273505-pcsw3vmx 21 26 to to IN cord-273505-pcsw3vmx 21 27 severe severe JJ cord-273505-pcsw3vmx 21 28 conditions condition NNS cord-273505-pcsw3vmx 21 29 with with IN cord-273505-pcsw3vmx 21 30 acute acute JJ cord-273505-pcsw3vmx 21 31 respiratory respiratory JJ cord-273505-pcsw3vmx 21 32 distress distress NN cord-273505-pcsw3vmx 21 33 syndrome syndrome NN cord-273505-pcsw3vmx 21 34 ( ( -LRB- cord-273505-pcsw3vmx 21 35 ARDS ARDS NNP cord-273505-pcsw3vmx 21 36 ) ) -RRB- cord-273505-pcsw3vmx 21 37 , , , cord-273505-pcsw3vmx 21 38 which which WDT cord-273505-pcsw3vmx 21 39 can can MD cord-273505-pcsw3vmx 21 40 result result VB cord-273505-pcsw3vmx 21 41 in in IN cord-273505-pcsw3vmx 21 42 shock shock NN cord-273505-pcsw3vmx 21 43 , , , cord-273505-pcsw3vmx 21 44 sepsis sepsis NN cord-273505-pcsw3vmx 21 45 , , , cord-273505-pcsw3vmx 21 46 and and CC cord-273505-pcsw3vmx 21 47 multiple multiple JJ cord-273505-pcsw3vmx 21 48 organ organ NN cord-273505-pcsw3vmx 21 49 dysfunction dysfunction NN cord-273505-pcsw3vmx 21 50 ( ( -LRB- cord-273505-pcsw3vmx 21 51 1 1 CD cord-273505-pcsw3vmx 21 52 , , , cord-273505-pcsw3vmx 21 53 2 2 CD cord-273505-pcsw3vmx 21 54 ) ) -RRB- cord-273505-pcsw3vmx 21 55 . . . cord-273505-pcsw3vmx 22 1 In in IN cord-273505-pcsw3vmx 22 2 addition addition NN cord-273505-pcsw3vmx 22 3 to to IN cord-273505-pcsw3vmx 22 4 supportive supportive JJ cord-273505-pcsw3vmx 22 5 treatment treatment NN cord-273505-pcsw3vmx 22 6 , , , cord-273505-pcsw3vmx 22 7 several several JJ cord-273505-pcsw3vmx 22 8 therapeutic therapeutic JJ cord-273505-pcsw3vmx 22 9 approaches approach NNS cord-273505-pcsw3vmx 22 10 have have VBP cord-273505-pcsw3vmx 22 11 been be VBN cord-273505-pcsw3vmx 22 12 proposed propose VBN cord-273505-pcsw3vmx 22 13 , , , cord-273505-pcsw3vmx 22 14 such such JJ cord-273505-pcsw3vmx 22 15 as as IN cord-273505-pcsw3vmx 22 16 antiviral antiviral JJ cord-273505-pcsw3vmx 22 17 therapy therapy NN cord-273505-pcsw3vmx 22 18 , , , cord-273505-pcsw3vmx 22 19 immunomodulators immunomodulator NNS cord-273505-pcsw3vmx 22 20 , , , cord-273505-pcsw3vmx 22 21 blood blood NN cord-273505-pcsw3vmx 22 22 products product NNS cord-273505-pcsw3vmx 22 23 , , , cord-273505-pcsw3vmx 22 24 and and CC cord-273505-pcsw3vmx 22 25 traditional traditional JJ cord-273505-pcsw3vmx 22 26 Chinese chinese JJ cord-273505-pcsw3vmx 22 27 medicine medicine NN cord-273505-pcsw3vmx 22 28 ( ( -LRB- cord-273505-pcsw3vmx 22 29 TCM TCM NNP cord-273505-pcsw3vmx 22 30 ) ) -RRB- cord-273505-pcsw3vmx 22 31 ( ( -LRB- cord-273505-pcsw3vmx 22 32 3 3 CD cord-273505-pcsw3vmx 22 33 , , , cord-273505-pcsw3vmx 22 34 4 4 CD cord-273505-pcsw3vmx 22 35 ) ) -RRB- cord-273505-pcsw3vmx 22 36 . . . cord-273505-pcsw3vmx 23 1 However however RB cord-273505-pcsw3vmx 23 2 , , , cord-273505-pcsw3vmx 23 3 the the DT cord-273505-pcsw3vmx 23 4 optimal optimal JJ cord-273505-pcsw3vmx 23 5 treatment treatment NN cord-273505-pcsw3vmx 23 6 strategy strategy NN cord-273505-pcsw3vmx 23 7 for for IN cord-273505-pcsw3vmx 23 8 severe severe JJ cord-273505-pcsw3vmx 23 9 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 23 10 remains remain NNS cord-273505-pcsw3vmx 23 11 debated debate VBN cord-273505-pcsw3vmx 23 12 ( ( -LRB- cord-273505-pcsw3vmx 23 13 5 5 LS cord-273505-pcsw3vmx 23 14 ) ) -RRB- cord-273505-pcsw3vmx 23 15 ( ( -LRB- cord-273505-pcsw3vmx 23 16 6 6 LS cord-273505-pcsw3vmx 23 17 ) ) -RRB- cord-273505-pcsw3vmx 23 18 ( ( -LRB- cord-273505-pcsw3vmx 23 19 7 7 LS cord-273505-pcsw3vmx 23 20 ) ) -RRB- cord-273505-pcsw3vmx 23 21 ( ( -LRB- cord-273505-pcsw3vmx 23 22 8) 8) NNP cord-273505-pcsw3vmx 23 23 ( ( -LRB- cord-273505-pcsw3vmx 23 24 9 9 CD cord-273505-pcsw3vmx 23 25 ) ) -RRB- cord-273505-pcsw3vmx 23 26 ( ( -LRB- cord-273505-pcsw3vmx 23 27 10 10 CD cord-273505-pcsw3vmx 23 28 ) ) -RRB- cord-273505-pcsw3vmx 23 29 ( ( -LRB- cord-273505-pcsw3vmx 23 30 11 11 CD cord-273505-pcsw3vmx 23 31 ) ) -RRB- cord-273505-pcsw3vmx 23 32 . . . cord-273505-pcsw3vmx 24 1 To to IN cord-273505-pcsw3vmx 24 2 date date NN cord-273505-pcsw3vmx 24 3 , , , cord-273505-pcsw3vmx 24 4 it -PRON- PRP cord-273505-pcsw3vmx 24 5 remains remain VBZ cord-273505-pcsw3vmx 24 6 an an DT cord-273505-pcsw3vmx 24 7 urgent urgent JJ cord-273505-pcsw3vmx 24 8 requirement requirement NN cord-273505-pcsw3vmx 24 9 to to TO cord-273505-pcsw3vmx 24 10 identify identify VB cord-273505-pcsw3vmx 24 11 the the DT cord-273505-pcsw3vmx 24 12 most most RBS cord-273505-pcsw3vmx 24 13 effective effective JJ cord-273505-pcsw3vmx 24 14 treatment treatment NN cord-273505-pcsw3vmx 24 15 for for IN cord-273505-pcsw3vmx 24 16 severe severe JJ cord-273505-pcsw3vmx 24 17 and and CC cord-273505-pcsw3vmx 24 18 critically critically RB cord-273505-pcsw3vmx 24 19 ill ill RB cord-273505-pcsw3vmx 24 20 COVID-19 covid-19 CD cord-273505-pcsw3vmx 24 21 patients patient NNS cord-273505-pcsw3vmx 24 22 , , , cord-273505-pcsw3vmx 24 23 but but CC cord-273505-pcsw3vmx 24 24 a a DT cord-273505-pcsw3vmx 24 25 conclusion conclusion NN cord-273505-pcsw3vmx 24 26 has have VBZ cord-273505-pcsw3vmx 24 27 not not RB cord-273505-pcsw3vmx 24 28 yet yet RB cord-273505-pcsw3vmx 24 29 been be VBN cord-273505-pcsw3vmx 24 30 drawn draw VBN cord-273505-pcsw3vmx 24 31 . . . cord-273505-pcsw3vmx 25 1 The the DT cord-273505-pcsw3vmx 25 2 severity severity NN cord-273505-pcsw3vmx 25 3 of of IN cord-273505-pcsw3vmx 25 4 respiratory respiratory JJ cord-273505-pcsw3vmx 25 5 viral viral JJ cord-273505-pcsw3vmx 25 6 infections infection NNS cord-273505-pcsw3vmx 25 7 depends depend VBZ cord-273505-pcsw3vmx 25 8 on on IN cord-273505-pcsw3vmx 25 9 a a DT cord-273505-pcsw3vmx 25 10 fine fine JJ cord-273505-pcsw3vmx 25 11 balance balance NN cord-273505-pcsw3vmx 25 12 between between IN cord-273505-pcsw3vmx 25 13 the the DT cord-273505-pcsw3vmx 25 14 virulence virulence NN cord-273505-pcsw3vmx 25 15 of of IN cord-273505-pcsw3vmx 25 16 the the DT cord-273505-pcsw3vmx 25 17 pathogen pathogen NN cord-273505-pcsw3vmx 25 18 and and CC cord-273505-pcsw3vmx 25 19 the the DT cord-273505-pcsw3vmx 25 20 inflammatory inflammatory JJ cord-273505-pcsw3vmx 25 21 response response NN cord-273505-pcsw3vmx 25 22 of of IN cord-273505-pcsw3vmx 25 23 the the DT cord-273505-pcsw3vmx 25 24 host host NN cord-273505-pcsw3vmx 25 25 's 's POS cord-273505-pcsw3vmx 25 26 immune immune JJ cord-273505-pcsw3vmx 25 27 system system NN cord-273505-pcsw3vmx 25 28 ( ( -LRB- cord-273505-pcsw3vmx 25 29 12 12 CD cord-273505-pcsw3vmx 25 30 ) ) -RRB- cord-273505-pcsw3vmx 25 31 . . . cord-273505-pcsw3vmx 26 1 Although although IN cord-273505-pcsw3vmx 26 2 an an DT cord-273505-pcsw3vmx 26 3 effective effective JJ cord-273505-pcsw3vmx 26 4 immune immune JJ cord-273505-pcsw3vmx 26 5 response response NN cord-273505-pcsw3vmx 26 6 is be VBZ cord-273505-pcsw3vmx 26 7 essential essential JJ cord-273505-pcsw3vmx 26 8 to to TO cord-273505-pcsw3vmx 26 9 eliminate eliminate VB cord-273505-pcsw3vmx 26 10 viral viral JJ cord-273505-pcsw3vmx 26 11 pathogens pathogen NNS cord-273505-pcsw3vmx 26 12 , , , cord-273505-pcsw3vmx 26 13 clinical clinical JJ cord-273505-pcsw3vmx 26 14 observations observation NNS cord-273505-pcsw3vmx 26 15 and and CC cord-273505-pcsw3vmx 26 16 experimental experimental JJ cord-273505-pcsw3vmx 26 17 data datum NNS cord-273505-pcsw3vmx 26 18 indicate indicate VBP cord-273505-pcsw3vmx 26 19 that that IN cord-273505-pcsw3vmx 26 20 an an DT cord-273505-pcsw3vmx 26 21 excessive excessive JJ cord-273505-pcsw3vmx 26 22 host host NN cord-273505-pcsw3vmx 26 23 immune immune JJ cord-273505-pcsw3vmx 26 24 responserather responserather RBR cord-273505-pcsw3vmx 26 25 than than IN cord-273505-pcsw3vmx 26 26 direct direct JJ cord-273505-pcsw3vmx 26 27 viral viral JJ cord-273505-pcsw3vmx 26 28 damage damage NN cord-273505-pcsw3vmx 26 29 - - : cord-273505-pcsw3vmx 26 30 primarily primarily RB cord-273505-pcsw3vmx 26 31 account account NN cord-273505-pcsw3vmx 26 32 for for IN cord-273505-pcsw3vmx 26 33 the the DT cord-273505-pcsw3vmx 26 34 pathological pathological JJ cord-273505-pcsw3vmx 26 35 injury injury NN cord-273505-pcsw3vmx 26 36 and and CC cord-273505-pcsw3vmx 26 37 clinical clinical JJ cord-273505-pcsw3vmx 26 38 deterioration deterioration NN cord-273505-pcsw3vmx 26 39 of of IN cord-273505-pcsw3vmx 26 40 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 26 41 ( ( -LRB- cord-273505-pcsw3vmx 26 42 12 12 CD cord-273505-pcsw3vmx 26 43 ) ) -RRB- cord-273505-pcsw3vmx 26 44 . . . cord-273505-pcsw3vmx 27 1 Inflammatory inflammatory JJ cord-273505-pcsw3vmx 27 2 cytokine cytokine NN cord-273505-pcsw3vmx 27 3 storms storm NNS cord-273505-pcsw3vmx 27 4 and and CC cord-273505-pcsw3vmx 27 5 lymphopenia lymphopenia NNP cord-273505-pcsw3vmx 27 6 are be VBP cord-273505-pcsw3vmx 27 7 the the DT cord-273505-pcsw3vmx 27 8 signature signature NN cord-273505-pcsw3vmx 27 9 features feature NNS cord-273505-pcsw3vmx 27 10 of of IN cord-273505-pcsw3vmx 27 11 patients patient NNS cord-273505-pcsw3vmx 27 12 with with IN cord-273505-pcsw3vmx 27 13 severe severe JJ cord-273505-pcsw3vmx 27 14 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 27 15 , , , cord-273505-pcsw3vmx 27 16 indicating indicate VBG cord-273505-pcsw3vmx 27 17 an an DT cord-273505-pcsw3vmx 27 18 intense intense JJ cord-273505-pcsw3vmx 27 19 systemic systemic JJ cord-273505-pcsw3vmx 27 20 inflammatory inflammatory JJ cord-273505-pcsw3vmx 27 21 response response NN cord-273505-pcsw3vmx 27 22 during during IN cord-273505-pcsw3vmx 27 23 SARS SARS NNP cord-273505-pcsw3vmx 27 24 - - HYPH cord-273505-pcsw3vmx 27 25 CoV-2 CoV-2 NNP cord-273505-pcsw3vmx 27 26 infection infection NN cord-273505-pcsw3vmx 27 27 ( ( -LRB- cord-273505-pcsw3vmx 27 28 13 13 CD cord-273505-pcsw3vmx 27 29 ) ) -RRB- cord-273505-pcsw3vmx 27 30 . . . cord-273505-pcsw3vmx 28 1 Specific specific JJ cord-273505-pcsw3vmx 28 2 adjuvant adjuvant JJ cord-273505-pcsw3vmx 28 3 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 28 4 treatments treatment NNS cord-273505-pcsw3vmx 28 5 have have VBP cord-273505-pcsw3vmx 28 6 been be VBN cord-273505-pcsw3vmx 28 7 considered consider VBN cord-273505-pcsw3vmx 28 8 for for IN cord-273505-pcsw3vmx 28 9 severe severe JJ cord-273505-pcsw3vmx 28 10 viral viral JJ cord-273505-pcsw3vmx 28 11 infections infection NNS cord-273505-pcsw3vmx 28 12 , , , cord-273505-pcsw3vmx 28 13 but but CC cord-273505-pcsw3vmx 28 14 some some DT cord-273505-pcsw3vmx 28 15 of of IN cord-273505-pcsw3vmx 28 16 these these DT cord-273505-pcsw3vmx 28 17 were be VBD cord-273505-pcsw3vmx 28 18 associated associate VBN cord-273505-pcsw3vmx 28 19 with with IN cord-273505-pcsw3vmx 28 20 a a DT cord-273505-pcsw3vmx 28 21 worse bad JJR cord-273505-pcsw3vmx 28 22 prognosis prognosis NN cord-273505-pcsw3vmx 28 23 . . . cord-273505-pcsw3vmx 29 1 Therefore therefore RB cord-273505-pcsw3vmx 29 2 , , , cord-273505-pcsw3vmx 29 3 it -PRON- PRP cord-273505-pcsw3vmx 29 4 is be VBZ cord-273505-pcsw3vmx 29 5 vital vital JJ cord-273505-pcsw3vmx 29 6 to to TO cord-273505-pcsw3vmx 29 7 select select VB cord-273505-pcsw3vmx 29 8 appropriate appropriate JJ cord-273505-pcsw3vmx 29 9 immunomodulators immunomodulator NNS cord-273505-pcsw3vmx 29 10 in in IN cord-273505-pcsw3vmx 29 11 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 29 12 patients patient NNS cord-273505-pcsw3vmx 29 13 and and CC cord-273505-pcsw3vmx 29 14 to to TO cord-273505-pcsw3vmx 29 15 carefully carefully RB cord-273505-pcsw3vmx 29 16 assess assess VB cord-273505-pcsw3vmx 29 17 their -PRON- PRP$ cord-273505-pcsw3vmx 29 18 benefits benefit NNS cord-273505-pcsw3vmx 29 19 and and CC cord-273505-pcsw3vmx 29 20 risks risk NNS cord-273505-pcsw3vmx 29 21 ( ( -LRB- cord-273505-pcsw3vmx 29 22 14 14 CD cord-273505-pcsw3vmx 29 23 , , , cord-273505-pcsw3vmx 29 24 15 15 CD cord-273505-pcsw3vmx 29 25 ) ) -RRB- cord-273505-pcsw3vmx 29 26 . . . cord-273505-pcsw3vmx 30 1 Based base VBN cord-273505-pcsw3vmx 30 2 on on IN cord-273505-pcsw3vmx 30 3 the the DT cord-273505-pcsw3vmx 30 4 previous previous JJ cord-273505-pcsw3vmx 30 5 clinical clinical JJ cord-273505-pcsw3vmx 30 6 experience experience NN cord-273505-pcsw3vmx 30 7 in in IN cord-273505-pcsw3vmx 30 8 China China NNP cord-273505-pcsw3vmx 30 9 , , , cord-273505-pcsw3vmx 30 10 it -PRON- PRP cord-273505-pcsw3vmx 30 11 was be VBD cord-273505-pcsw3vmx 30 12 proposed propose VBN cord-273505-pcsw3vmx 30 13 that that IN cord-273505-pcsw3vmx 30 14 early early JJ cord-273505-pcsw3vmx 30 15 initiation initiation NN cord-273505-pcsw3vmx 30 16 of of IN cord-273505-pcsw3vmx 30 17 high high JJ cord-273505-pcsw3vmx 30 18 - - HYPH cord-273505-pcsw3vmx 30 19 dose dose NN cord-273505-pcsw3vmx 30 20 intravenous intravenous JJ cord-273505-pcsw3vmx 30 21 immunoglobulins immunoglobulin NNS cord-273505-pcsw3vmx 30 22 ( ( -LRB- cord-273505-pcsw3vmx 30 23 IVIg ivig ADD cord-273505-pcsw3vmx 30 24 ) ) -RRB- cord-273505-pcsw3vmx 30 25 and and CC cord-273505-pcsw3vmx 30 26 low low JJ cord-273505-pcsw3vmx 30 27 - - HYPH cord-273505-pcsw3vmx 30 28 molecular molecular JJ cord-273505-pcsw3vmx 30 29 - - HYPH cord-273505-pcsw3vmx 30 30 weight weight NN cord-273505-pcsw3vmx 30 31 heparin heparin NN cord-273505-pcsw3vmx 30 32 might may MD cord-273505-pcsw3vmx 30 33 be be VB cord-273505-pcsw3vmx 30 34 effective effective JJ cord-273505-pcsw3vmx 30 35 in in IN cord-273505-pcsw3vmx 30 36 improving improve VBG cord-273505-pcsw3vmx 30 37 the the DT cord-273505-pcsw3vmx 30 38 prognosis prognosis NN cord-273505-pcsw3vmx 30 39 of of IN cord-273505-pcsw3vmx 30 40 severe severe JJ cord-273505-pcsw3vmx 30 41 and and CC cord-273505-pcsw3vmx 30 42 critically critically RB cord-273505-pcsw3vmx 30 43 ill ill RB cord-273505-pcsw3vmx 30 44 COVID-19 covid-19 CD cord-273505-pcsw3vmx 30 45 patients patient NNS cord-273505-pcsw3vmx 30 46 ( ( -LRB- cord-273505-pcsw3vmx 30 47 16 16 CD cord-273505-pcsw3vmx 30 48 , , , cord-273505-pcsw3vmx 30 49 17 17 CD cord-273505-pcsw3vmx 30 50 ) ) -RRB- cord-273505-pcsw3vmx 30 51 . . . cord-273505-pcsw3vmx 31 1 The the DT cord-273505-pcsw3vmx 31 2 national national JJ cord-273505-pcsw3vmx 31 3 diagnosis diagnosis NN cord-273505-pcsw3vmx 31 4 and and CC cord-273505-pcsw3vmx 31 5 treatment treatment NN cord-273505-pcsw3vmx 31 6 protocol protocol NN cord-273505-pcsw3vmx 31 7 for for IN cord-273505-pcsw3vmx 31 8 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 32 1 ( ( -LRB- cord-273505-pcsw3vmx 32 2 Trial Trial NNP cord-273505-pcsw3vmx 32 3 Version Version NNP cord-273505-pcsw3vmx 32 4 7 7 CD cord-273505-pcsw3vmx 32 5 ) ) -RRB- cord-273505-pcsw3vmx 32 6 and and CC cord-273505-pcsw3vmx 32 7 recommendations recommendation NNS cord-273505-pcsw3vmx 32 8 from from IN cord-273505-pcsw3vmx 32 9 the the DT cord-273505-pcsw3vmx 32 10 Peking Peking NNP cord-273505-pcsw3vmx 32 11 Union Union NNP cord-273505-pcsw3vmx 32 12 Medical Medical NNP cord-273505-pcsw3vmx 32 13 College College NNP cord-273505-pcsw3vmx 32 14 Hospital Hospital NNP cord-273505-pcsw3vmx 33 1 recommend recommend VB cord-273505-pcsw3vmx 33 2 appropriate appropriate JJ cord-273505-pcsw3vmx 33 3 application application NN cord-273505-pcsw3vmx 33 4 of of IN cord-273505-pcsw3vmx 33 5 IVIg ivig JJ cord-273505-pcsw3vmx 33 6 therapy therapy NN cord-273505-pcsw3vmx 33 7 in in IN cord-273505-pcsw3vmx 33 8 severe severe JJ cord-273505-pcsw3vmx 33 9 and and CC cord-273505-pcsw3vmx 33 10 critical critical JJ cord-273505-pcsw3vmx 33 11 COVID-19 covid-19 CD cord-273505-pcsw3vmx 33 12 cases case NNS cord-273505-pcsw3vmx 33 13 ( ( -LRB- cord-273505-pcsw3vmx 33 14 4 4 CD cord-273505-pcsw3vmx 33 15 , , , cord-273505-pcsw3vmx 33 16 18 18 CD cord-273505-pcsw3vmx 33 17 ) ) -RRB- cord-273505-pcsw3vmx 33 18 . . . cord-273505-pcsw3vmx 34 1 However however RB cord-273505-pcsw3vmx 34 2 , , , cord-273505-pcsw3vmx 34 3 the the DT cord-273505-pcsw3vmx 34 4 specific specific JJ cord-273505-pcsw3vmx 34 5 molecular molecular JJ cord-273505-pcsw3vmx 34 6 mechanisms mechanism NNS cord-273505-pcsw3vmx 34 7 and and CC cord-273505-pcsw3vmx 34 8 clinical clinical JJ cord-273505-pcsw3vmx 34 9 effectiveness effectiveness NN cord-273505-pcsw3vmx 34 10 of of IN cord-273505-pcsw3vmx 34 11 IVIg ivig JJ cord-273505-pcsw3vmx 34 12 treatment treatment NN cord-273505-pcsw3vmx 34 13 remain remain VBP cord-273505-pcsw3vmx 34 14 unclear unclear JJ cord-273505-pcsw3vmx 34 15 . . . cord-273505-pcsw3vmx 35 1 Here here RB cord-273505-pcsw3vmx 35 2 , , , cord-273505-pcsw3vmx 35 3 we -PRON- PRP cord-273505-pcsw3vmx 35 4 review review VBP cord-273505-pcsw3vmx 35 5 the the DT cord-273505-pcsw3vmx 35 6 current current JJ cord-273505-pcsw3vmx 35 7 knowledge knowledge NN cord-273505-pcsw3vmx 35 8 of of IN cord-273505-pcsw3vmx 35 9 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 35 10 mechanisms mechanism NNS cord-273505-pcsw3vmx 35 11 of of IN cord-273505-pcsw3vmx 35 12 high high JJ cord-273505-pcsw3vmx 35 13 - - HYPH cord-273505-pcsw3vmx 35 14 dose dose NN cord-273505-pcsw3vmx 35 15 IVIg ivig NN cord-273505-pcsw3vmx 35 16 and and CC cord-273505-pcsw3vmx 35 17 discuss discuss VB cord-273505-pcsw3vmx 35 18 its -PRON- PRP$ cord-273505-pcsw3vmx 35 19 potential potential JJ cord-273505-pcsw3vmx 35 20 role role NN cord-273505-pcsw3vmx 35 21 in in IN cord-273505-pcsw3vmx 35 22 treating treat VBG cord-273505-pcsw3vmx 35 23 severe severe JJ cord-273505-pcsw3vmx 35 24 viral viral JJ cord-273505-pcsw3vmx 35 25 infection infection NN cord-273505-pcsw3vmx 35 26 . . . cord-273505-pcsw3vmx 36 1 Moreover moreover RB cord-273505-pcsw3vmx 36 2 , , , cord-273505-pcsw3vmx 36 3 we -PRON- PRP cord-273505-pcsw3vmx 36 4 summarize summarize VBP cord-273505-pcsw3vmx 36 5 the the DT cord-273505-pcsw3vmx 36 6 clinical clinical JJ cord-273505-pcsw3vmx 36 7 efficacy efficacy NN cord-273505-pcsw3vmx 36 8 of of IN cord-273505-pcsw3vmx 36 9 IVIg ivig JJ cord-273505-pcsw3vmx 36 10 therapy therapy NN cord-273505-pcsw3vmx 36 11 in in IN cord-273505-pcsw3vmx 36 12 treating treat VBG cord-273505-pcsw3vmx 36 13 severe severe JJ cord-273505-pcsw3vmx 36 14 viral viral JJ cord-273505-pcsw3vmx 36 15 pneumonias pneumonia NNS cord-273505-pcsw3vmx 36 16 such such JJ cord-273505-pcsw3vmx 36 17 as as IN cord-273505-pcsw3vmx 36 18 that that DT cord-273505-pcsw3vmx 36 19 caused cause VBN cord-273505-pcsw3vmx 36 20 by by IN cord-273505-pcsw3vmx 36 21 SARS SARS NNP cord-273505-pcsw3vmx 36 22 , , , cord-273505-pcsw3vmx 36 23 MERS MERS NNP cord-273505-pcsw3vmx 36 24 , , , cord-273505-pcsw3vmx 36 25 influenza influenza NN cord-273505-pcsw3vmx 36 26 , , , cord-273505-pcsw3vmx 36 27 and and CC cord-273505-pcsw3vmx 36 28 RSV RSV NNP cord-273505-pcsw3vmx 36 29 disease disease NN cord-273505-pcsw3vmx 36 30 , , , cord-273505-pcsw3vmx 36 31 and and CC cord-273505-pcsw3vmx 36 32 its -PRON- PRP$ cord-273505-pcsw3vmx 36 33 current current JJ cord-273505-pcsw3vmx 36 34 application application NN cord-273505-pcsw3vmx 36 35 in in IN cord-273505-pcsw3vmx 36 36 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 36 37 . . . cord-273505-pcsw3vmx 37 1 A a DT cord-273505-pcsw3vmx 37 2 thorough thorough JJ cord-273505-pcsw3vmx 37 3 understanding understanding NN cord-273505-pcsw3vmx 37 4 of of IN cord-273505-pcsw3vmx 37 5 the the DT cord-273505-pcsw3vmx 37 6 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 37 7 mechanisms mechanism NNS cord-273505-pcsw3vmx 37 8 of of IN cord-273505-pcsw3vmx 37 9 IVIg ivig NN cord-273505-pcsw3vmx 37 10 therapy therapy NN cord-273505-pcsw3vmx 37 11 is be VBZ cord-273505-pcsw3vmx 37 12 crucial crucial JJ cord-273505-pcsw3vmx 37 13 for for IN cord-273505-pcsw3vmx 37 14 the the DT cord-273505-pcsw3vmx 37 15 timing timing NN cord-273505-pcsw3vmx 37 16 and and CC cord-273505-pcsw3vmx 37 17 dosing dosing NN cord-273505-pcsw3vmx 37 18 of of IN cord-273505-pcsw3vmx 37 19 early early JJ cord-273505-pcsw3vmx 37 20 intervention intervention NN cord-273505-pcsw3vmx 37 21 and and CC cord-273505-pcsw3vmx 37 22 may may MD cord-273505-pcsw3vmx 37 23 provide provide VB cord-273505-pcsw3vmx 37 24 much much RB cord-273505-pcsw3vmx 37 25 - - HYPH cord-273505-pcsw3vmx 37 26 needed need VBN cord-273505-pcsw3vmx 37 27 insights insight NNS cord-273505-pcsw3vmx 37 28 into into IN cord-273505-pcsw3vmx 37 29 the the DT cord-273505-pcsw3vmx 37 30 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 37 31 treatment treatment NN cord-273505-pcsw3vmx 37 32 of of IN cord-273505-pcsw3vmx 37 33 severe severe JJ cord-273505-pcsw3vmx 37 34 and and CC cord-273505-pcsw3vmx 37 35 critically critically RB cord-273505-pcsw3vmx 37 36 ill ill RB cord-273505-pcsw3vmx 37 37 COVID-19 covid-19 CD cord-273505-pcsw3vmx 37 38 patients patient NNS cord-273505-pcsw3vmx 37 39 . . . cord-273505-pcsw3vmx 38 1 IVIg IVIg NNP cord-273505-pcsw3vmx 38 2 is be VBZ cord-273505-pcsw3vmx 38 3 a a DT cord-273505-pcsw3vmx 38 4 blood blood NN cord-273505-pcsw3vmx 38 5 preparation preparation NN cord-273505-pcsw3vmx 38 6 isolated isolate VBN cord-273505-pcsw3vmx 38 7 and and CC cord-273505-pcsw3vmx 38 8 concentrated concentrate VBN cord-273505-pcsw3vmx 38 9 from from IN cord-273505-pcsw3vmx 38 10 healthy healthy JJ cord-273505-pcsw3vmx 38 11 donors donor NNS cord-273505-pcsw3vmx 38 12 consisting consist VBG cord-273505-pcsw3vmx 38 13 of of IN cord-273505-pcsw3vmx 38 14 over over IN cord-273505-pcsw3vmx 38 15 95 95 CD cord-273505-pcsw3vmx 38 16 % % NN cord-273505-pcsw3vmx 38 17 of of IN cord-273505-pcsw3vmx 38 18 IgG igg NN cord-273505-pcsw3vmx 38 19 and and CC cord-273505-pcsw3vmx 38 20 trace trace NN cord-273505-pcsw3vmx 38 21 amounts amount NNS cord-273505-pcsw3vmx 38 22 of of IN cord-273505-pcsw3vmx 38 23 IgA IgA NNP cord-273505-pcsw3vmx 38 24 or or CC cord-273505-pcsw3vmx 38 25 IgM. IgM. NNP cord-273505-pcsw3vmx 38 26 IVIg IVIg NNP cord-273505-pcsw3vmx 38 27 has have VBZ cord-273505-pcsw3vmx 38 28 been be VBN cord-273505-pcsw3vmx 38 29 used use VBN cord-273505-pcsw3vmx 38 30 in in IN cord-273505-pcsw3vmx 38 31 clinical clinical JJ cord-273505-pcsw3vmx 38 32 practice practice NN cord-273505-pcsw3vmx 38 33 for for IN cord-273505-pcsw3vmx 38 34 many many JJ cord-273505-pcsw3vmx 38 35 years year NNS cord-273505-pcsw3vmx 38 36 . . . cord-273505-pcsw3vmx 39 1 Different different JJ cord-273505-pcsw3vmx 39 2 doses dose NNS cord-273505-pcsw3vmx 39 3 of of IN cord-273505-pcsw3vmx 39 4 IVIg IVIg NNS cord-273505-pcsw3vmx 39 5 serve serve VBP cord-273505-pcsw3vmx 39 6 diverse diverse JJ cord-273505-pcsw3vmx 39 7 medical medical JJ cord-273505-pcsw3vmx 39 8 indications indication NNS cord-273505-pcsw3vmx 39 9 , , , cord-273505-pcsw3vmx 39 10 and and CC cord-273505-pcsw3vmx 39 11 the the DT cord-273505-pcsw3vmx 39 12 clinical clinical JJ cord-273505-pcsw3vmx 39 13 efficacy efficacy NN cord-273505-pcsw3vmx 39 14 of of IN cord-273505-pcsw3vmx 39 15 IVIg IVIg NNP cord-273505-pcsw3vmx 39 16 differs differ VBZ cord-273505-pcsw3vmx 39 17 with with IN cord-273505-pcsw3vmx 39 18 dosage dosage NN cord-273505-pcsw3vmx 39 19 ( ( -LRB- cord-273505-pcsw3vmx 39 20 19 19 CD cord-273505-pcsw3vmx 39 21 ) ) -RRB- cord-273505-pcsw3vmx 39 22 . . . cord-273505-pcsw3vmx 40 1 At at IN cord-273505-pcsw3vmx 40 2 low low JJ cord-273505-pcsw3vmx 40 3 and and CC cord-273505-pcsw3vmx 40 4 moderate moderate JJ cord-273505-pcsw3vmx 40 5 doses dose NNS cord-273505-pcsw3vmx 40 6 , , , cord-273505-pcsw3vmx 40 7 IVIg IVIg NNP cord-273505-pcsw3vmx 40 8 can can MD cord-273505-pcsw3vmx 40 9 be be VB cord-273505-pcsw3vmx 40 10 administered administer VBN cord-273505-pcsw3vmx 40 11 as as IN cord-273505-pcsw3vmx 40 12 substitutional substitutional JJ cord-273505-pcsw3vmx 40 13 therapy therapy NN cord-273505-pcsw3vmx 40 14 for for IN cord-273505-pcsw3vmx 40 15 primary primary JJ cord-273505-pcsw3vmx 40 16 or or CC cord-273505-pcsw3vmx 40 17 acquired acquire VBN cord-273505-pcsw3vmx 40 18 immunodeficiencies immunodeficiency NNS cord-273505-pcsw3vmx 40 19 in in IN cord-273505-pcsw3vmx 40 20 order order NN cord-273505-pcsw3vmx 40 21 to to TO cord-273505-pcsw3vmx 40 22 improve improve VB cord-273505-pcsw3vmx 40 23 plasma plasma NN cord-273505-pcsw3vmx 40 24 IgG igg NN cord-273505-pcsw3vmx 40 25 concentrations concentration NNS cord-273505-pcsw3vmx 40 26 and and CC cord-273505-pcsw3vmx 40 27 provide provide VB cord-273505-pcsw3vmx 40 28 passive passive JJ cord-273505-pcsw3vmx 40 29 immunity immunity NN cord-273505-pcsw3vmx 40 30 that that WDT cord-273505-pcsw3vmx 40 31 allows allow VBZ cord-273505-pcsw3vmx 40 32 for for IN cord-273505-pcsw3vmx 40 33 immediate immediate JJ cord-273505-pcsw3vmx 40 34 protection protection NN cord-273505-pcsw3vmx 40 35 against against IN cord-273505-pcsw3vmx 40 36 microbes microbe NNS cord-273505-pcsw3vmx 40 37 in in IN cord-273505-pcsw3vmx 40 38 immunodeficient immunodeficient JJ cord-273505-pcsw3vmx 40 39 patients patient NNS cord-273505-pcsw3vmx 40 40 . . . cord-273505-pcsw3vmx 41 1 In in IN cord-273505-pcsw3vmx 41 2 vitro vitro FW cord-273505-pcsw3vmx 41 3 and and CC cord-273505-pcsw3vmx 41 4 preclinical preclinical JJ cord-273505-pcsw3vmx 41 5 experiments experiment NNS cord-273505-pcsw3vmx 41 6 confirmed confirm VBD cord-273505-pcsw3vmx 41 7 that that IN cord-273505-pcsw3vmx 41 8 IVIg IVIg NNP cord-273505-pcsw3vmx 41 9 contains contain VBZ cord-273505-pcsw3vmx 41 10 multivalent multivalent JJ cord-273505-pcsw3vmx 41 11 pathogen pathogen NN cord-273505-pcsw3vmx 41 12 - - HYPH cord-273505-pcsw3vmx 41 13 specific specific JJ cord-273505-pcsw3vmx 41 14 neutralizing neutralize VBG cord-273505-pcsw3vmx 41 15 IgG igg NN cord-273505-pcsw3vmx 41 16 antibodies antibody NNS cord-273505-pcsw3vmx 41 17 against against IN cord-273505-pcsw3vmx 41 18 common common JJ cord-273505-pcsw3vmx 41 19 opportunistic opportunistic JJ cord-273505-pcsw3vmx 41 20 pathogens pathogen NNS cord-273505-pcsw3vmx 41 21 and and CC cord-273505-pcsw3vmx 41 22 toxins toxin NNS cord-273505-pcsw3vmx 41 23 ( ( -LRB- cord-273505-pcsw3vmx 41 24 e.g. e.g. RB cord-273505-pcsw3vmx 41 25 , , , cord-273505-pcsw3vmx 41 26 Enterococcus Enterococcus NNP cord-273505-pcsw3vmx 41 27 spp spp NNS cord-273505-pcsw3vmx 41 28 . . . cord-273505-pcsw3vmx 42 1 , , , cord-273505-pcsw3vmx 42 2 Haemophilus haemophilus JJ cord-273505-pcsw3vmx 42 3 influenzae influenzae NN cord-273505-pcsw3vmx 42 4 type type NN cord-273505-pcsw3vmx 42 5 b b NN cord-273505-pcsw3vmx 42 6 , , , cord-273505-pcsw3vmx 42 7 Streptococcus streptococcus NN cord-273505-pcsw3vmx 42 8 pyogenes pyogene NNS cord-273505-pcsw3vmx 42 9 , , , cord-273505-pcsw3vmx 42 10 Staphylococcus Staphylococcus NNP cord-273505-pcsw3vmx 42 11 aureus aureus NN cord-273505-pcsw3vmx 42 12 , , , cord-273505-pcsw3vmx 42 13 cytomegalovirus cytomegalovirus NN cord-273505-pcsw3vmx 42 14 , , , cord-273505-pcsw3vmx 42 15 and and CC cord-273505-pcsw3vmx 42 16 Shiga Shiga NNP cord-273505-pcsw3vmx 42 17 toxins toxin NNS cord-273505-pcsw3vmx 42 18 ) ) -RRB- cord-273505-pcsw3vmx 42 19 ( ( -LRB- cord-273505-pcsw3vmx 42 20 21 21 CD cord-273505-pcsw3vmx 42 21 ) ) -RRB- cord-273505-pcsw3vmx 42 22 ( ( -LRB- cord-273505-pcsw3vmx 42 23 22 22 CD cord-273505-pcsw3vmx 42 24 ) ) -RRB- cord-273505-pcsw3vmx 42 25 ( ( -LRB- cord-273505-pcsw3vmx 42 26 23 23 CD cord-273505-pcsw3vmx 42 27 ) ) -RRB- cord-273505-pcsw3vmx 42 28 ( ( -LRB- cord-273505-pcsw3vmx 42 29 24 24 CD cord-273505-pcsw3vmx 42 30 ) ) -RRB- cord-273505-pcsw3vmx 42 31 ( ( -LRB- cord-273505-pcsw3vmx 42 32 25 25 CD cord-273505-pcsw3vmx 42 33 ) ) -RRB- cord-273505-pcsw3vmx 42 34 ( ( -LRB- cord-273505-pcsw3vmx 42 35 26 26 CD cord-273505-pcsw3vmx 42 36 ) ) -RRB- cord-273505-pcsw3vmx 42 37 . . . cord-273505-pcsw3vmx 43 1 Variance variance NN cord-273505-pcsw3vmx 43 2 in in IN cord-273505-pcsw3vmx 43 3 pathogen pathogen NN cord-273505-pcsw3vmx 43 4 - - HYPH cord-273505-pcsw3vmx 43 5 specific specific JJ cord-273505-pcsw3vmx 43 6 antibody antibody NN cord-273505-pcsw3vmx 43 7 titer titer NN cord-273505-pcsw3vmx 43 8 and and CC cord-273505-pcsw3vmx 43 9 neutralizing neutralize VBG cord-273505-pcsw3vmx 43 10 activity activity NN cord-273505-pcsw3vmx 43 11 is be VBZ cord-273505-pcsw3vmx 43 12 usually usually RB cord-273505-pcsw3vmx 43 13 observed observe VBN cord-273505-pcsw3vmx 43 14 among among IN cord-273505-pcsw3vmx 43 15 various various JJ cord-273505-pcsw3vmx 43 16 IVIg ivig NN cord-273505-pcsw3vmx 43 17 preparations preparation NNS cord-273505-pcsw3vmx 43 18 , , , cord-273505-pcsw3vmx 43 19 and and CC cord-273505-pcsw3vmx 43 20 is be VBZ cord-273505-pcsw3vmx 43 21 most most RBS cord-273505-pcsw3vmx 43 22 likely likely JJ cord-273505-pcsw3vmx 43 23 due due IN cord-273505-pcsw3vmx 43 24 to to IN cord-273505-pcsw3vmx 43 25 differences difference NNS cord-273505-pcsw3vmx 43 26 in in IN cord-273505-pcsw3vmx 43 27 the the DT cord-273505-pcsw3vmx 43 28 geographical geographical JJ cord-273505-pcsw3vmx 43 29 regions region NNS cord-273505-pcsw3vmx 43 30 where where WRB cord-273505-pcsw3vmx 43 31 plasma plasma NN cord-273505-pcsw3vmx 43 32 samples sample NNS cord-273505-pcsw3vmx 43 33 were be VBD cord-273505-pcsw3vmx 43 34 collected collect VBN cord-273505-pcsw3vmx 43 35 , , , cord-273505-pcsw3vmx 43 36 reflecting reflect VBG cord-273505-pcsw3vmx 43 37 differences difference NNS cord-273505-pcsw3vmx 43 38 in in IN cord-273505-pcsw3vmx 43 39 pathogen pathogen NN cord-273505-pcsw3vmx 43 40 exposure exposure NN cord-273505-pcsw3vmx 43 41 ( ( -LRB- cord-273505-pcsw3vmx 43 42 27 27 CD cord-273505-pcsw3vmx 43 43 - - SYM cord-273505-pcsw3vmx 43 44 29 29 CD cord-273505-pcsw3vmx 43 45 ) ) -RRB- cord-273505-pcsw3vmx 43 46 . . . cord-273505-pcsw3vmx 44 1 In in IN cord-273505-pcsw3vmx 44 2 addition addition NN cord-273505-pcsw3vmx 44 3 to to IN cord-273505-pcsw3vmx 44 4 microbial microbial JJ cord-273505-pcsw3vmx 44 5 binding binding NN cord-273505-pcsw3vmx 44 6 , , , cord-273505-pcsw3vmx 44 7 a a DT cord-273505-pcsw3vmx 44 8 wide wide JJ cord-273505-pcsw3vmx 44 9 range range NN cord-273505-pcsw3vmx 44 10 of of IN cord-273505-pcsw3vmx 44 11 endogenous endogenous JJ cord-273505-pcsw3vmx 44 12 antigen antigen NN cord-273505-pcsw3vmx 44 13 - - HYPH cord-273505-pcsw3vmx 44 14 specific specific JJ cord-273505-pcsw3vmx 44 15 IgG igg NN cord-273505-pcsw3vmx 44 16 are be VBP cord-273505-pcsw3vmx 44 17 also also RB cord-273505-pcsw3vmx 44 18 present present JJ cord-273505-pcsw3vmx 44 19 in in IN cord-273505-pcsw3vmx 44 20 IVIg ivig JJ cord-273505-pcsw3vmx 44 21 preparations preparation NNS cord-273505-pcsw3vmx 44 22 . . . cord-273505-pcsw3vmx 45 1 These these DT cord-273505-pcsw3vmx 45 2 endogenous endogenous JJ cord-273505-pcsw3vmx 45 3 antigens antigen NNS cord-273505-pcsw3vmx 45 4 may may MD cord-273505-pcsw3vmx 45 5 include include VB cord-273505-pcsw3vmx 45 6 : : : cord-273505-pcsw3vmx 45 7 inflammatory inflammatory JJ cord-273505-pcsw3vmx 45 8 cytokines cytokine NNS cord-273505-pcsw3vmx 45 9 ( ( -LRB- cord-273505-pcsw3vmx 45 10 e.g. e.g. RB cord-273505-pcsw3vmx 45 11 , , , cord-273505-pcsw3vmx 45 12 IL-1α IL-1α NNP cord-273505-pcsw3vmx 45 13 , , , cord-273505-pcsw3vmx 45 14 IFN IFN NNP cord-273505-pcsw3vmx 45 15 - - HYPH cord-273505-pcsw3vmx 45 16 α2a α2a NNP cord-273505-pcsw3vmx 45 17 , , , cord-273505-pcsw3vmx 45 18 and and CC cord-273505-pcsw3vmx 45 19 GM GM NNP cord-273505-pcsw3vmx 45 20 - - HYPH cord-273505-pcsw3vmx 45 21 CSF CSF NNP cord-273505-pcsw3vmx 45 22 ) ) -RRB- cord-273505-pcsw3vmx 45 23 , , , cord-273505-pcsw3vmx 45 24 chemokines chemokine NNS cord-273505-pcsw3vmx 45 25 ( ( -LRB- cord-273505-pcsw3vmx 45 26 e.g. e.g. RB cord-273505-pcsw3vmx 45 27 , , , cord-273505-pcsw3vmx 45 28 CCR5 CCR5 NNP cord-273505-pcsw3vmx 45 29 ) ) -RRB- cord-273505-pcsw3vmx 45 30 , , , cord-273505-pcsw3vmx 45 31 apoptosis apoptosis NN cord-273505-pcsw3vmx 45 32 - - HYPH cord-273505-pcsw3vmx 45 33 related relate VBN cord-273505-pcsw3vmx 45 34 molecules molecule NNS cord-273505-pcsw3vmx 45 35 ( ( -LRB- cord-273505-pcsw3vmx 45 36 e.g. e.g. RB cord-273505-pcsw3vmx 45 37 , , , cord-273505-pcsw3vmx 45 38 Siglec-8 Siglec-8 NNP cord-273505-pcsw3vmx 45 39 , , , cord-273505-pcsw3vmx 45 40 Siglec-9 Siglec-9 NNP cord-273505-pcsw3vmx 45 41 , , , cord-273505-pcsw3vmx 45 42 CD95 CD95 NNP cord-273505-pcsw3vmx 45 43 / / SYM cord-273505-pcsw3vmx 45 44 Fas Fas NNP cord-273505-pcsw3vmx 45 45 , , , cord-273505-pcsw3vmx 45 46 BAFF BAFF NNP cord-273505-pcsw3vmx 45 47 , , , cord-273505-pcsw3vmx 45 48 and and CC cord-273505-pcsw3vmx 45 49 APRIL APRIL NNP cord-273505-pcsw3vmx 45 50 ) ) -RRB- cord-273505-pcsw3vmx 45 51 , , , cord-273505-pcsw3vmx 45 52 complement complement NN cord-273505-pcsw3vmx 45 53 fragments fragment NNS cord-273505-pcsw3vmx 45 54 ( ( -LRB- cord-273505-pcsw3vmx 45 55 C3a c3a NN cord-273505-pcsw3vmx 45 56 and and CC cord-273505-pcsw3vmx 45 57 C5a C5a NNS cord-273505-pcsw3vmx 45 58 ) ) -RRB- cord-273505-pcsw3vmx 45 59 , , , cord-273505-pcsw3vmx 45 60 and and CC cord-273505-pcsw3vmx 45 61 anti anti JJ cord-273505-pcsw3vmx 45 62 - - JJ cord-273505-pcsw3vmx 45 63 idiotypic idiotypic JJ cord-273505-pcsw3vmx 45 64 antibodies antibody NNS cord-273505-pcsw3vmx 45 65 ( ( -LRB- cord-273505-pcsw3vmx 45 66 e.g. e.g. RB cord-273505-pcsw3vmx 45 67 , , , cord-273505-pcsw3vmx 45 68 anti anti JJ cord-273505-pcsw3vmx 45 69 - - JJ cord-273505-pcsw3vmx 45 70 amyloid amyloid JJ cord-273505-pcsw3vmx 45 71 β β NNP cord-273505-pcsw3vmx 45 72 antibodies antibody NNS cord-273505-pcsw3vmx 45 73 and and CC cord-273505-pcsw3vmx 45 74 anti anti JJ cord-273505-pcsw3vmx 45 75 - - JJ cord-273505-pcsw3vmx 45 76 coagulation coagulation JJ cord-273505-pcsw3vmx 45 77 factor factor NN cord-273505-pcsw3vmx 45 78 VIII VIII NNP cord-273505-pcsw3vmx 45 79 antibodies antibody NNS cord-273505-pcsw3vmx 45 80 ) ) -RRB- cord-273505-pcsw3vmx 45 81 ( ( -LRB- cord-273505-pcsw3vmx 45 82 30 30 CD cord-273505-pcsw3vmx 45 83 - - SYM cord-273505-pcsw3vmx 45 84 41 41 CD cord-273505-pcsw3vmx 45 85 ) ) -RRB- cord-273505-pcsw3vmx 45 86 . . . cord-273505-pcsw3vmx 46 1 F(ab f(ab NN cord-273505-pcsw3vmx 46 2 ) ) -RRB- cord-273505-pcsw3vmx 46 3 ′ ′ CD cord-273505-pcsw3vmx 46 4 2mediated 2mediated CD cord-273505-pcsw3vmx 46 5 neutralization neutralization NN cord-273505-pcsw3vmx 46 6 of of IN cord-273505-pcsw3vmx 46 7 inflammatory inflammatory JJ cord-273505-pcsw3vmx 46 8 cytokines cytokine NNS cord-273505-pcsw3vmx 46 9 , , , cord-273505-pcsw3vmx 46 10 chemokines chemokine NNS cord-273505-pcsw3vmx 46 11 , , , cord-273505-pcsw3vmx 46 12 and and CC cord-273505-pcsw3vmx 46 13 complement complement VB cord-273505-pcsw3vmx 46 14 fragments fragment NNS cord-273505-pcsw3vmx 46 15 , , , cord-273505-pcsw3vmx 46 16 along along IN cord-273505-pcsw3vmx 46 17 with with IN cord-273505-pcsw3vmx 46 18 regulation regulation NN cord-273505-pcsw3vmx 46 19 of of IN cord-273505-pcsw3vmx 46 20 immune immune JJ cord-273505-pcsw3vmx 46 21 cell cell NN cord-273505-pcsw3vmx 46 22 apoptosis apoptosis NN cord-273505-pcsw3vmx 46 23 might may MD cord-273505-pcsw3vmx 46 24 contribute contribute VB cord-273505-pcsw3vmx 46 25 to to IN cord-273505-pcsw3vmx 46 26 the the DT cord-273505-pcsw3vmx 46 27 conversion conversion NN cord-273505-pcsw3vmx 46 28 of of IN cord-273505-pcsw3vmx 46 29 proinflammatory proinflammatory JJ cord-273505-pcsw3vmx 46 30 to to IN cord-273505-pcsw3vmx 46 31 anti anti JJ cord-273505-pcsw3vmx 46 32 - - JJ cord-273505-pcsw3vmx 46 33 inflammatory inflammatory JJ cord-273505-pcsw3vmx 46 34 conditions condition NNS cord-273505-pcsw3vmx 46 35 . . . cord-273505-pcsw3vmx 47 1 Meanwhile meanwhile RB cord-273505-pcsw3vmx 47 2 , , , cord-273505-pcsw3vmx 47 3 a a DT cord-273505-pcsw3vmx 47 4 possible possible JJ cord-273505-pcsw3vmx 47 5 explanation explanation NN cord-273505-pcsw3vmx 47 6 for for IN cord-273505-pcsw3vmx 47 7 the the DT cord-273505-pcsw3vmx 47 8 fact fact NN cord-273505-pcsw3vmx 47 9 that that IN cord-273505-pcsw3vmx 47 10 only only RB cord-273505-pcsw3vmx 47 11 high high JJ cord-273505-pcsw3vmx 47 12 - - HYPH cord-273505-pcsw3vmx 47 13 dose dose NN cord-273505-pcsw3vmx 47 14 IVIg ivig NN cord-273505-pcsw3vmx 47 15 can can MD cord-273505-pcsw3vmx 47 16 exert exert VB cord-273505-pcsw3vmx 47 17 anti anti JJ cord-273505-pcsw3vmx 47 18 - - JJ cord-273505-pcsw3vmx 47 19 inflammatory inflammatory JJ cord-273505-pcsw3vmx 47 20 effects effect NNS cord-273505-pcsw3vmx 47 21 is be VBZ cord-273505-pcsw3vmx 47 22 that that IN cord-273505-pcsw3vmx 47 23 a a DT cord-273505-pcsw3vmx 47 24 sufficient sufficient JJ cord-273505-pcsw3vmx 47 25 amount amount NN cord-273505-pcsw3vmx 47 26 of of IN cord-273505-pcsw3vmx 47 27 antigen antigen NN cord-273505-pcsw3vmx 47 28 - - HYPH cord-273505-pcsw3vmx 47 29 specific specific JJ cord-273505-pcsw3vmx 47 30 IgG igg NN cord-273505-pcsw3vmx 47 31 is be VBZ cord-273505-pcsw3vmx 47 32 required require VBN cord-273505-pcsw3vmx 47 33 to to TO cord-273505-pcsw3vmx 47 34 achieve achieve VB cord-273505-pcsw3vmx 47 35 therapeutic therapeutic JJ cord-273505-pcsw3vmx 47 36 activity activity NN cord-273505-pcsw3vmx 47 37 . . . cord-273505-pcsw3vmx 48 1 However however RB cord-273505-pcsw3vmx 48 2 , , , cord-273505-pcsw3vmx 48 3 as as IN cord-273505-pcsw3vmx 48 4 previous previous JJ cord-273505-pcsw3vmx 48 5 research research NN cord-273505-pcsw3vmx 48 6 revealed reveal VBD cord-273505-pcsw3vmx 48 7 that that IN cord-273505-pcsw3vmx 48 8 preparations preparation NNS cord-273505-pcsw3vmx 48 9 with with IN cord-273505-pcsw3vmx 48 10 purified purify VBN cord-273505-pcsw3vmx 48 11 Fc Fc NNP cord-273505-pcsw3vmx 48 12 fragments fragment NNS cord-273505-pcsw3vmx 48 13 of of IN cord-273505-pcsw3vmx 48 14 IgG IgG NNP cord-273505-pcsw3vmx 48 15 had have VBD cord-273505-pcsw3vmx 48 16 an an DT cord-273505-pcsw3vmx 48 17 undamped undamped JJ cord-273505-pcsw3vmx 48 18 effect effect NN cord-273505-pcsw3vmx 48 19 compared compare VBN cord-273505-pcsw3vmx 48 20 with with IN cord-273505-pcsw3vmx 48 21 intact intact JJ cord-273505-pcsw3vmx 48 22 IgG igg NN cord-273505-pcsw3vmx 48 23 for for IN cord-273505-pcsw3vmx 48 24 some some DT cord-273505-pcsw3vmx 48 25 indications indication NNS cord-273505-pcsw3vmx 48 26 , , , cord-273505-pcsw3vmx 48 27 F(ab f(ab NN cord-273505-pcsw3vmx 48 28 ) ) -RRB- cord-273505-pcsw3vmx 49 1 ′ ′ CD cord-273505-pcsw3vmx 49 2 2 2 CD cord-273505-pcsw3vmx 49 3 -mediated -mediated JJ cord-273505-pcsw3vmx 49 4 mechanisms mechanism NNS cord-273505-pcsw3vmx 49 5 alone alone RB cord-273505-pcsw3vmx 49 6 may may MD cord-273505-pcsw3vmx 49 7 not not RB cord-273505-pcsw3vmx 49 8 be be VB cord-273505-pcsw3vmx 49 9 sufficient sufficient JJ cord-273505-pcsw3vmx 49 10 for for IN cord-273505-pcsw3vmx 49 11 the the DT cord-273505-pcsw3vmx 49 12 extensive extensive JJ cord-273505-pcsw3vmx 49 13 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 49 14 effects effect NNS cord-273505-pcsw3vmx 49 15 of of IN cord-273505-pcsw3vmx 49 16 high high JJ cord-273505-pcsw3vmx 49 17 - - HYPH cord-273505-pcsw3vmx 49 18 dose dose NN cord-273505-pcsw3vmx 49 19 IVIg ivig NN cord-273505-pcsw3vmx 49 20 therapy therapy NN cord-273505-pcsw3vmx 49 21 ( ( -LRB- cord-273505-pcsw3vmx 49 22 42 42 CD cord-273505-pcsw3vmx 49 23 - - SYM cord-273505-pcsw3vmx 49 24 44 44 CD cord-273505-pcsw3vmx 49 25 ) ) -RRB- cord-273505-pcsw3vmx 49 26 . . . cord-273505-pcsw3vmx 50 1 Therefore therefore RB cord-273505-pcsw3vmx 50 2 , , , cord-273505-pcsw3vmx 50 3 Fc Fc NNP cord-273505-pcsw3vmx 50 4 - - HYPH cord-273505-pcsw3vmx 50 5 mediated mediate VBN cord-273505-pcsw3vmx 50 6 mechanisms mechanism NNS cord-273505-pcsw3vmx 50 7 may may MD cord-273505-pcsw3vmx 50 8 play play VB cord-273505-pcsw3vmx 50 9 a a DT cord-273505-pcsw3vmx 50 10 decisive decisive JJ cord-273505-pcsw3vmx 50 11 role role NN cord-273505-pcsw3vmx 50 12 in in IN cord-273505-pcsw3vmx 50 13 these these DT cord-273505-pcsw3vmx 50 14 processes process NNS cord-273505-pcsw3vmx 50 15 . . . cord-273505-pcsw3vmx 51 1 The the DT cord-273505-pcsw3vmx 51 2 Fc Fc NNP cord-273505-pcsw3vmx 51 3 fragment fragment NN cord-273505-pcsw3vmx 51 4 of of IN cord-273505-pcsw3vmx 51 5 IgG IgG NNP cord-273505-pcsw3vmx 51 6 is be VBZ cord-273505-pcsw3vmx 51 7 responsible responsible JJ cord-273505-pcsw3vmx 51 8 for for IN cord-273505-pcsw3vmx 51 9 binding bind VBG cord-273505-pcsw3vmx 51 10 to to IN cord-273505-pcsw3vmx 51 11 Fc Fc NNP cord-273505-pcsw3vmx 51 12 receptors receptor NNS cord-273505-pcsw3vmx 51 13 ( ( -LRB- cord-273505-pcsw3vmx 51 14 FcRs FcRs NNP cord-273505-pcsw3vmx 51 15 ) ) -RRB- cord-273505-pcsw3vmx 51 16 and and CC cord-273505-pcsw3vmx 51 17 complement complement NN cord-273505-pcsw3vmx 51 18 ( ( -LRB- cord-273505-pcsw3vmx 51 19 e.g. e.g. RB cord-273505-pcsw3vmx 51 20 , , , cord-273505-pcsw3vmx 51 21 C1q C1q NNP cord-273505-pcsw3vmx 51 22 , , , cord-273505-pcsw3vmx 51 23 C3b C3b NNP cord-273505-pcsw3vmx 51 24 , , , cord-273505-pcsw3vmx 51 25 and and CC cord-273505-pcsw3vmx 51 26 C4b c4b NN cord-273505-pcsw3vmx 51 27 ) ) -RRB- cord-273505-pcsw3vmx 51 28 . . . cord-273505-pcsw3vmx 52 1 IgG IgG NNP cord-273505-pcsw3vmx 52 2 - - HYPH cord-273505-pcsw3vmx 52 3 specific specific JJ cord-273505-pcsw3vmx 52 4 Fc Fc NNP cord-273505-pcsw3vmx 52 5 receptors receptor NNS cord-273505-pcsw3vmx 52 6 ( ( -LRB- cord-273505-pcsw3vmx 52 7 FcγRs FcγRs NNP cord-273505-pcsw3vmx 52 8 ) ) -RRB- cord-273505-pcsw3vmx 52 9 belong belong VBP cord-273505-pcsw3vmx 52 10 to to IN cord-273505-pcsw3vmx 52 11 type type NN cord-273505-pcsw3vmx 52 12 I -PRON- PRP cord-273505-pcsw3vmx 52 13 FcRs FcRs NNP cord-273505-pcsw3vmx 52 14 and and CC cord-273505-pcsw3vmx 52 15 are be VBP cord-273505-pcsw3vmx 52 16 classified classify VBN cord-273505-pcsw3vmx 52 17 into into IN cord-273505-pcsw3vmx 52 18 activating activate VBG cord-273505-pcsw3vmx 52 19 FcγRs FcγRs NNP cord-273505-pcsw3vmx 52 20 ( ( -LRB- cord-273505-pcsw3vmx 52 21 FcγRI FcγRI NNP cord-273505-pcsw3vmx 52 22 , , , cord-273505-pcsw3vmx 52 23 FcγRIIA FcγRIIA NNP cord-273505-pcsw3vmx 52 24 , , , cord-273505-pcsw3vmx 52 25 FcγRIIC FcγRIIC NNP cord-273505-pcsw3vmx 52 26 , , , cord-273505-pcsw3vmx 52 27 FcγRIIIA FcγRIIIA NNP cord-273505-pcsw3vmx 52 28 , , , cord-273505-pcsw3vmx 52 29 and and CC cord-273505-pcsw3vmx 52 30 FcγRIIIB FcγRIIIB NNP cord-273505-pcsw3vmx 52 31 ) ) -RRB- cord-273505-pcsw3vmx 52 32 and and CC cord-273505-pcsw3vmx 52 33 an an DT cord-273505-pcsw3vmx 52 34 inhibitory inhibitory JJ cord-273505-pcsw3vmx 52 35 FcγR fcγr NN cord-273505-pcsw3vmx 52 36 ( ( -LRB- cord-273505-pcsw3vmx 52 37 FcγRIIB FcγRIIB NNP cord-273505-pcsw3vmx 52 38 ) ) -RRB- cord-273505-pcsw3vmx 52 39 , , , cord-273505-pcsw3vmx 52 40 depending depend VBG cord-273505-pcsw3vmx 52 41 on on IN cord-273505-pcsw3vmx 52 42 their -PRON- PRP$ cord-273505-pcsw3vmx 52 43 intracellular intracellular JJ cord-273505-pcsw3vmx 52 44 motif motif NN cord-273505-pcsw3vmx 52 45 and and CC cord-273505-pcsw3vmx 52 46 the the DT cord-273505-pcsw3vmx 52 47 function function NN cord-273505-pcsw3vmx 52 48 they -PRON- PRP cord-273505-pcsw3vmx 52 49 mediate mediate VBP cord-273505-pcsw3vmx 52 50 . . . cord-273505-pcsw3vmx 53 1 Type Type NNP cord-273505-pcsw3vmx 53 2 II II NNP cord-273505-pcsw3vmx 53 3 FcRs FcRs NNP cord-273505-pcsw3vmx 53 4 , , , cord-273505-pcsw3vmx 53 5 including include VBG cord-273505-pcsw3vmx 53 6 C c NN cord-273505-pcsw3vmx 53 7 - - HYPH cord-273505-pcsw3vmx 53 8 type type NN cord-273505-pcsw3vmx 53 9 lectins lectin NNS cord-273505-pcsw3vmx 53 10 ( ( -LRB- cord-273505-pcsw3vmx 53 11 DC DC NNP cord-273505-pcsw3vmx 53 12 - - HYPH cord-273505-pcsw3vmx 53 13 SIGN SIGN NNP cord-273505-pcsw3vmx 53 14 , , , cord-273505-pcsw3vmx 53 15 DCIR DCIR NNP cord-273505-pcsw3vmx 53 16 ) ) -RRB- cord-273505-pcsw3vmx 54 1 , , , cord-273505-pcsw3vmx 54 2 type type NN cord-273505-pcsw3vmx 54 3 I -PRON- PRP cord-273505-pcsw3vmx 54 4 lectins lectin NNS cord-273505-pcsw3vmx 54 5 ( ( -LRB- cord-273505-pcsw3vmx 54 6 CD22 CD22 NNP cord-273505-pcsw3vmx 54 7 ) ) -RRB- cord-273505-pcsw3vmx 54 8 , , , cord-273505-pcsw3vmx 54 9 and and CC cord-273505-pcsw3vmx 54 10 non non JJ cord-273505-pcsw3vmx 54 11 - - JJ cord-273505-pcsw3vmx 54 12 classical classical JJ cord-273505-pcsw3vmx 54 13 FcRs FcRs NNP cord-273505-pcsw3vmx 54 14 , , , cord-273505-pcsw3vmx 54 15 such such JJ cord-273505-pcsw3vmx 54 16 as as IN cord-273505-pcsw3vmx 54 17 FcRn FcRn NNP cord-273505-pcsw3vmx 54 18 and and CC cord-273505-pcsw3vmx 54 19 FCRL FCRL NNP cord-273505-pcsw3vmx 54 20 , , , cord-273505-pcsw3vmx 54 21 also also RB cord-273505-pcsw3vmx 54 22 act act VBP cord-273505-pcsw3vmx 54 23 as as IN cord-273505-pcsw3vmx 54 24 effector effector JJ cord-273505-pcsw3vmx 54 25 targets target NNS cord-273505-pcsw3vmx 54 26 of of IN cord-273505-pcsw3vmx 54 27 IVIg IVIg NNP cord-273505-pcsw3vmx 54 28 ( ( -LRB- cord-273505-pcsw3vmx 54 29 Figure figure NN cord-273505-pcsw3vmx 54 30 2 2 CD cord-273505-pcsw3vmx 54 31 ) ) -RRB- cord-273505-pcsw3vmx 54 32 . . . cord-273505-pcsw3vmx 55 1 The the DT cord-273505-pcsw3vmx 55 2 Fc Fc NNP cord-273505-pcsw3vmx 55 3 - - HYPH cord-273505-pcsw3vmx 55 4 mediated mediate VBN cord-273505-pcsw3vmx 55 5 mechanisms mechanism NNS cord-273505-pcsw3vmx 55 6 of of IN cord-273505-pcsw3vmx 55 7 high high JJ cord-273505-pcsw3vmx 55 8 - - HYPH cord-273505-pcsw3vmx 55 9 dose dose NN cord-273505-pcsw3vmx 55 10 IVIg ivig NN cord-273505-pcsw3vmx 55 11 therapy therapy NN cord-273505-pcsw3vmx 55 12 include include VBP cord-273505-pcsw3vmx 55 13 saturation saturation NN cord-273505-pcsw3vmx 55 14 of of IN cord-273505-pcsw3vmx 55 15 activating activate VBG cord-273505-pcsw3vmx 55 16 FcγRs FcγRs NNP cord-273505-pcsw3vmx 55 17 and and CC cord-273505-pcsw3vmx 55 18 FcRn FcRn NNP cord-273505-pcsw3vmx 55 19 , , , cord-273505-pcsw3vmx 55 20 upregulation upregulation NN cord-273505-pcsw3vmx 55 21 of of IN cord-273505-pcsw3vmx 55 22 the the DT cord-273505-pcsw3vmx 55 23 inhibitory inhibitory JJ cord-273505-pcsw3vmx 55 24 FcγRIIB fcγriib NN cord-273505-pcsw3vmx 55 25 , , , cord-273505-pcsw3vmx 55 26 and and CC cord-273505-pcsw3vmx 55 27 scavenging scavenging NN cord-273505-pcsw3vmx 55 28 of of IN cord-273505-pcsw3vmx 55 29 complement complement NN cord-273505-pcsw3vmx 55 30 molecules molecule NNS cord-273505-pcsw3vmx 55 31 . . . cord-273505-pcsw3vmx 56 1 Given give VBN cord-273505-pcsw3vmx 56 2 the the DT cord-273505-pcsw3vmx 56 3 central central JJ cord-273505-pcsw3vmx 56 4 role role NN cord-273505-pcsw3vmx 56 5 of of IN cord-273505-pcsw3vmx 56 6 activating activate VBG cord-273505-pcsw3vmx 56 7 FcγRs fcγr NNS cord-273505-pcsw3vmx 56 8 in in IN cord-273505-pcsw3vmx 56 9 mediating mediate VBG cord-273505-pcsw3vmx 56 10 excessive excessive JJ cord-273505-pcsw3vmx 56 11 antibody antibody NN cord-273505-pcsw3vmx 56 12 - - HYPH cord-273505-pcsw3vmx 56 13 dependent dependent JJ cord-273505-pcsw3vmx 56 14 effector effector NN cord-273505-pcsw3vmx 56 15 functions function NNS cord-273505-pcsw3vmx 56 16 , , , cord-273505-pcsw3vmx 56 17 a a DT cord-273505-pcsw3vmx 56 18 possible possible JJ cord-273505-pcsw3vmx 56 19 explanation explanation NN cord-273505-pcsw3vmx 56 20 of of IN cord-273505-pcsw3vmx 56 21 the the DT cord-273505-pcsw3vmx 56 22 potential potential JJ cord-273505-pcsw3vmx 56 23 anti anti JJ cord-273505-pcsw3vmx 56 24 - - JJ cord-273505-pcsw3vmx 56 25 inflammatory inflammatory JJ cord-273505-pcsw3vmx 56 26 function function NN cord-273505-pcsw3vmx 56 27 of of IN cord-273505-pcsw3vmx 56 28 high high JJ cord-273505-pcsw3vmx 56 29 - - HYPH cord-273505-pcsw3vmx 56 30 dose dose NN cord-273505-pcsw3vmx 56 31 IVIg ivig NN cord-273505-pcsw3vmx 56 32 lies lie VBZ cord-273505-pcsw3vmx 56 33 in in IN cord-273505-pcsw3vmx 56 34 that that IN cord-273505-pcsw3vmx 56 35 it -PRON- PRP cord-273505-pcsw3vmx 56 36 significantly significantly RB cord-273505-pcsw3vmx 56 37 raises raise VBZ cord-273505-pcsw3vmx 56 38 the the DT cord-273505-pcsw3vmx 56 39 concentration concentration NN cord-273505-pcsw3vmx 56 40 of of IN cord-273505-pcsw3vmx 56 41 IgG igg NN cord-273505-pcsw3vmx 56 42 above above IN cord-273505-pcsw3vmx 56 43 the the DT cord-273505-pcsw3vmx 56 44 normal normal JJ cord-273505-pcsw3vmx 56 45 plasma plasma NN cord-273505-pcsw3vmx 56 46 levels level NNS cord-273505-pcsw3vmx 56 47 and and CC cord-273505-pcsw3vmx 56 48 contributes contribute VBZ cord-273505-pcsw3vmx 56 49 to to IN cord-273505-pcsw3vmx 56 50 a a DT cord-273505-pcsw3vmx 56 51 functional functional JJ cord-273505-pcsw3vmx 56 52 blockade blockade NN cord-273505-pcsw3vmx 56 53 of of IN cord-273505-pcsw3vmx 56 54 FcγRs FcγRs NNP cord-273505-pcsw3vmx 56 55 , , , cord-273505-pcsw3vmx 56 56 limiting limit VBG cord-273505-pcsw3vmx 56 57 access access NN cord-273505-pcsw3vmx 56 58 of of IN cord-273505-pcsw3vmx 56 59 immune immune JJ cord-273505-pcsw3vmx 56 60 complexes complex NNS cord-273505-pcsw3vmx 56 61 to to IN cord-273505-pcsw3vmx 56 62 these these DT cord-273505-pcsw3vmx 56 63 activating activate VBG cord-273505-pcsw3vmx 56 64 receptors receptor NNS cord-273505-pcsw3vmx 56 65 . . . cord-273505-pcsw3vmx 57 1 Moreover moreover RB cord-273505-pcsw3vmx 57 2 , , , cord-273505-pcsw3vmx 57 3 IgG igg NN cord-273505-pcsw3vmx 57 4 from from IN cord-273505-pcsw3vmx 57 5 IVIg ivig JJ cord-273505-pcsw3vmx 57 6 preparations preparation NNS cord-273505-pcsw3vmx 57 7 has have VBZ cord-273505-pcsw3vmx 57 8 been be VBN cord-273505-pcsw3vmx 57 9 proven prove VBN cord-273505-pcsw3vmx 57 10 to to TO cord-273505-pcsw3vmx 57 11 be be VB cord-273505-pcsw3vmx 57 12 active active JJ cord-273505-pcsw3vmx 57 13 through through IN cord-273505-pcsw3vmx 57 14 inhibitory inhibitory JJ cord-273505-pcsw3vmx 57 15 ITAMi ITAMi NNS cord-273505-pcsw3vmx 57 16 signaling signal VBG cord-273505-pcsw3vmx 57 17 in in IN cord-273505-pcsw3vmx 57 18 immune immune JJ cord-273505-pcsw3vmx 57 19 regulation regulation NN cord-273505-pcsw3vmx 57 20 ( ( -LRB- cord-273505-pcsw3vmx 57 21 45 45 CD cord-273505-pcsw3vmx 57 22 ) ) -RRB- cord-273505-pcsw3vmx 57 23 . . . cord-273505-pcsw3vmx 58 1 The the DT cord-273505-pcsw3vmx 58 2 role role NN cord-273505-pcsw3vmx 58 3 of of IN cord-273505-pcsw3vmx 58 4 dimeric dimeric JJ cord-273505-pcsw3vmx 58 5 IgG igg NN cord-273505-pcsw3vmx 58 6 in in IN cord-273505-pcsw3vmx 58 7 IVIg IVIg NNP cord-273505-pcsw3vmx 58 8 preparations preparation NNS cord-273505-pcsw3vmx 58 9 is be VBZ cord-273505-pcsw3vmx 58 10 emphasized emphasize VBN cord-273505-pcsw3vmx 58 11 by by IN cord-273505-pcsw3vmx 58 12 an an DT cord-273505-pcsw3vmx 58 13 enhanced enhanced JJ cord-273505-pcsw3vmx 58 14 understanding understanding NN cord-273505-pcsw3vmx 58 15 of of IN cord-273505-pcsw3vmx 58 16 the the DT cord-273505-pcsw3vmx 58 17 optimal optimal JJ cord-273505-pcsw3vmx 58 18 IgG igg NN cord-273505-pcsw3vmx 58 19 form form NN cord-273505-pcsw3vmx 58 20 to to TO cord-273505-pcsw3vmx 58 21 interact interact VB cord-273505-pcsw3vmx 58 22 with with IN cord-273505-pcsw3vmx 58 23 activating activate VBG cord-273505-pcsw3vmx 58 24 FcγRs FcγRs NNP cord-273505-pcsw3vmx 58 25 . . . cord-273505-pcsw3vmx 59 1 In in IN cord-273505-pcsw3vmx 59 2 physiological physiological JJ cord-273505-pcsw3vmx 59 3 conditions condition NNS cord-273505-pcsw3vmx 59 4 , , , cord-273505-pcsw3vmx 59 5 monomeric monomeric JJ cord-273505-pcsw3vmx 59 6 IgG1 igg1 NN cord-273505-pcsw3vmx 59 7 is be VBZ cord-273505-pcsw3vmx 59 8 more more RBR cord-273505-pcsw3vmx 59 9 likely likely JJ cord-273505-pcsw3vmx 59 10 to to TO cord-273505-pcsw3vmx 59 11 bind bind VB cord-273505-pcsw3vmx 59 12 FcγRI FcγRI NNP cord-273505-pcsw3vmx 59 13 with with IN cord-273505-pcsw3vmx 59 14 high high JJ cord-273505-pcsw3vmx 59 15 affinity affinity NN cord-273505-pcsw3vmx 59 16 rather rather RB cord-273505-pcsw3vmx 59 17 than than IN cord-273505-pcsw3vmx 59 18 to to IN cord-273505-pcsw3vmx 59 19 other other JJ cord-273505-pcsw3vmx 59 20 FcγRs fcγrs XX cord-273505-pcsw3vmx 59 21 with with IN cord-273505-pcsw3vmx 59 22 low low JJ cord-273505-pcsw3vmx 59 23 affinity affinity NN cord-273505-pcsw3vmx 59 24 ( ( -LRB- cord-273505-pcsw3vmx 59 25 46 46 CD cord-273505-pcsw3vmx 59 26 ) ) -RRB- cord-273505-pcsw3vmx 59 27 . . . cord-273505-pcsw3vmx 60 1 Although although IN cord-273505-pcsw3vmx 60 2 monomeric monomeric JJ cord-273505-pcsw3vmx 60 3 IgG igg NN cord-273505-pcsw3vmx 60 4 at at IN cord-273505-pcsw3vmx 60 5 therapeutic therapeutic JJ cord-273505-pcsw3vmx 60 6 levels level NNS cord-273505-pcsw3vmx 60 7 are be VBP cord-273505-pcsw3vmx 60 8 able able JJ cord-273505-pcsw3vmx 60 9 to to TO cord-273505-pcsw3vmx 60 10 saturate saturate VB cord-273505-pcsw3vmx 60 11 lowaffinity lowaffinity NN cord-273505-pcsw3vmx 60 12 FcγR fcγr NN cord-273505-pcsw3vmx 60 13 in in IN cord-273505-pcsw3vmx 60 14 a a DT cord-273505-pcsw3vmx 60 15 dose dose NN cord-273505-pcsw3vmx 60 16 - - HYPH cord-273505-pcsw3vmx 60 17 dependent dependent JJ cord-273505-pcsw3vmx 60 18 manner manner NN cord-273505-pcsw3vmx 60 19 , , , cord-273505-pcsw3vmx 60 20 it -PRON- PRP cord-273505-pcsw3vmx 60 21 has have VBZ cord-273505-pcsw3vmx 60 22 been be VBN cord-273505-pcsw3vmx 60 23 suggested suggest VBN cord-273505-pcsw3vmx 60 24 that that IN cord-273505-pcsw3vmx 60 25 the the DT cord-273505-pcsw3vmx 60 26 small small JJ cord-273505-pcsw3vmx 60 27 amounts amount NNS cord-273505-pcsw3vmx 60 28 of of IN cord-273505-pcsw3vmx 60 29 dimeric dimeric JJ cord-273505-pcsw3vmx 60 30 IgG igg NN cord-273505-pcsw3vmx 60 31 bind bind VBP cord-273505-pcsw3vmx 60 32 with with IN cord-273505-pcsw3vmx 60 33 higher high JJR cord-273505-pcsw3vmx 60 34 avidity avidity NN cord-273505-pcsw3vmx 60 35 to to IN cord-273505-pcsw3vmx 60 36 FcγRs FcγRs NNP cord-273505-pcsw3vmx 60 37 , , , cord-273505-pcsw3vmx 60 38 and and CC cord-273505-pcsw3vmx 60 39 therefore therefore RB cord-273505-pcsw3vmx 60 40 constitute constitute VBP cord-273505-pcsw3vmx 60 41 the the DT cord-273505-pcsw3vmx 60 42 main main JJ cord-273505-pcsw3vmx 60 43 active active JJ cord-273505-pcsw3vmx 60 44 component component NN cord-273505-pcsw3vmx 60 45 of of IN cord-273505-pcsw3vmx 60 46 IVIg IVIg NNP cord-273505-pcsw3vmx 60 47 mediating mediate VBG cord-273505-pcsw3vmx 60 48 FcγR fcγr JJ cord-273505-pcsw3vmx 60 49 blockade blockade NN cord-273505-pcsw3vmx 60 50 , , , cord-273505-pcsw3vmx 60 51 explaining explain VBG cord-273505-pcsw3vmx 60 52 the the DT cord-273505-pcsw3vmx 60 53 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 60 54 function function NN cord-273505-pcsw3vmx 60 55 of of IN cord-273505-pcsw3vmx 60 56 high high JJ cord-273505-pcsw3vmx 60 57 - - HYPH cord-273505-pcsw3vmx 60 58 dose dose NN cord-273505-pcsw3vmx 60 59 IVIg ivig NN cord-273505-pcsw3vmx 60 60 in in IN cord-273505-pcsw3vmx 60 61 ITP ITP NNP cord-273505-pcsw3vmx 60 62 , , , cord-273505-pcsw3vmx 60 63 GBS GBS NNP cord-273505-pcsw3vmx 60 64 , , , cord-273505-pcsw3vmx 60 65 and and CC cord-273505-pcsw3vmx 60 66 CIDP CIDP NNP cord-273505-pcsw3vmx 60 67 patients patient NNS cord-273505-pcsw3vmx 60 68 ( ( -LRB- cord-273505-pcsw3vmx 60 69 47 47 CD cord-273505-pcsw3vmx 60 70 - - SYM cord-273505-pcsw3vmx 60 71 51 51 CD cord-273505-pcsw3vmx 60 72 ) ) -RRB- cord-273505-pcsw3vmx 60 73 . . . cord-273505-pcsw3vmx 61 1 Endogenous endogenous JJ cord-273505-pcsw3vmx 61 2 pathogenic pathogenic JJ cord-273505-pcsw3vmx 61 3 autoantibodies autoantibody NNS cord-273505-pcsw3vmx 61 4 , , , cord-273505-pcsw3vmx 61 5 mainly mainly RB cord-273505-pcsw3vmx 61 6 IgG IgG NNP cord-273505-pcsw3vmx 61 7 , , , cord-273505-pcsw3vmx 61 8 play play VB cord-273505-pcsw3vmx 61 9 a a DT cord-273505-pcsw3vmx 61 10 predominant predominant JJ cord-273505-pcsw3vmx 61 11 role role NN cord-273505-pcsw3vmx 61 12 in in IN cord-273505-pcsw3vmx 61 13 the the DT cord-273505-pcsw3vmx 61 14 immunopathogenesis immunopathogenesis NN cord-273505-pcsw3vmx 61 15 of of IN cord-273505-pcsw3vmx 61 16 many many JJ cord-273505-pcsw3vmx 61 17 autoimmune autoimmune JJ cord-273505-pcsw3vmx 61 18 and and CC cord-273505-pcsw3vmx 61 19 infectious infectious JJ cord-273505-pcsw3vmx 61 20 diseases disease NNS cord-273505-pcsw3vmx 61 21 . . . cord-273505-pcsw3vmx 62 1 A a DT cord-273505-pcsw3vmx 62 2 hallmark hallmark JJ cord-273505-pcsw3vmx 62 3 characteristic characteristic NN cord-273505-pcsw3vmx 62 4 of of IN cord-273505-pcsw3vmx 62 5 long long JJ cord-273505-pcsw3vmx 62 6 serum serum NN cord-273505-pcsw3vmx 62 7 half half JJ cord-273505-pcsw3vmx 62 8 - - HYPH cord-273505-pcsw3vmx 62 9 life life NN cord-273505-pcsw3vmx 62 10 of of IN cord-273505-pcsw3vmx 62 11 endogenous endogenous JJ cord-273505-pcsw3vmx 62 12 pathogenic pathogenic JJ cord-273505-pcsw3vmx 62 13 IgG igg NN cord-273505-pcsw3vmx 62 14 is be VBZ cord-273505-pcsw3vmx 62 15 mainly mainly RB cord-273505-pcsw3vmx 62 16 due due JJ cord-273505-pcsw3vmx 62 17 to to IN cord-273505-pcsw3vmx 62 18 FcRn FcRn NNP cord-273505-pcsw3vmx 62 19 . . . cord-273505-pcsw3vmx 63 1 FcRn FcRn NNP cord-273505-pcsw3vmx 63 2 is be VBZ cord-273505-pcsw3vmx 63 3 a a DT cord-273505-pcsw3vmx 63 4 non non JJ cord-273505-pcsw3vmx 63 5 - - JJ cord-273505-pcsw3vmx 63 6 classical classical JJ cord-273505-pcsw3vmx 63 7 FcR fcr NN cord-273505-pcsw3vmx 63 8 that that WDT cord-273505-pcsw3vmx 63 9 can can MD cord-273505-pcsw3vmx 63 10 interact interact VB cord-273505-pcsw3vmx 63 11 with with IN cord-273505-pcsw3vmx 63 12 IgG IgG NNP cord-273505-pcsw3vmx 63 13 in in IN cord-273505-pcsw3vmx 63 14 a a DT cord-273505-pcsw3vmx 63 15 pH ph JJ cord-273505-pcsw3vmx 63 16 - - HYPH cord-273505-pcsw3vmx 63 17 dependent dependent JJ cord-273505-pcsw3vmx 63 18 manner manner NN cord-273505-pcsw3vmx 63 19 , , , cord-273505-pcsw3vmx 63 20 which which WDT cord-273505-pcsw3vmx 63 21 is be VBZ cord-273505-pcsw3vmx 63 22 sufficient sufficient JJ cord-273505-pcsw3vmx 63 23 in in IN cord-273505-pcsw3vmx 63 24 rescuing rescue VBG cord-273505-pcsw3vmx 63 25 IgG igg NN cord-273505-pcsw3vmx 63 26 from from IN cord-273505-pcsw3vmx 63 27 lysosomal lysosomal JJ cord-273505-pcsw3vmx 63 28 degradation degradation NN cord-273505-pcsw3vmx 63 29 and and CC cord-273505-pcsw3vmx 63 30 recycling recycle VBG cord-273505-pcsw3vmx 63 31 it -PRON- PRP cord-273505-pcsw3vmx 63 32 to to IN cord-273505-pcsw3vmx 63 33 the the DT cord-273505-pcsw3vmx 63 34 cell cell NN cord-273505-pcsw3vmx 63 35 surface surface NN cord-273505-pcsw3vmx 63 36 ( ( -LRB- cord-273505-pcsw3vmx 63 37 52 52 CD cord-273505-pcsw3vmx 63 38 , , , cord-273505-pcsw3vmx 63 39 53 53 CD cord-273505-pcsw3vmx 63 40 ) ) -RRB- cord-273505-pcsw3vmx 63 41 . . . cord-273505-pcsw3vmx 64 1 High high JJ cord-273505-pcsw3vmx 64 2 - - HYPH cord-273505-pcsw3vmx 64 3 dose dose NN cord-273505-pcsw3vmx 64 4 IVIg ivig NN cord-273505-pcsw3vmx 64 5 therapy therapy NN cord-273505-pcsw3vmx 64 6 leads lead VBZ cord-273505-pcsw3vmx 64 7 to to IN cord-273505-pcsw3vmx 64 8 an an DT cord-273505-pcsw3vmx 64 9 increased increase VBN cord-273505-pcsw3vmx 64 10 clearance clearance NN cord-273505-pcsw3vmx 64 11 rate rate NN cord-273505-pcsw3vmx 64 12 of of IN cord-273505-pcsw3vmx 64 13 monoclonal monoclonal JJ cord-273505-pcsw3vmx 64 14 antibodies antibody NNS cord-273505-pcsw3vmx 64 15 and and CC cord-273505-pcsw3vmx 64 16 pathogenic pathogenic JJ cord-273505-pcsw3vmx 64 17 IgG igg NN cord-273505-pcsw3vmx 64 18 in in IN cord-273505-pcsw3vmx 64 19 different different JJ cord-273505-pcsw3vmx 64 20 mouse mouse NN cord-273505-pcsw3vmx 64 21 models model NNS cord-273505-pcsw3vmx 64 22 , , , cord-273505-pcsw3vmx 64 23 whereas whereas IN cord-273505-pcsw3vmx 64 24 this this DT cord-273505-pcsw3vmx 64 25 effect effect NN cord-273505-pcsw3vmx 64 26 is be VBZ cord-273505-pcsw3vmx 64 27 not not RB cord-273505-pcsw3vmx 64 28 observed observe VBN cord-273505-pcsw3vmx 64 29 in in IN cord-273505-pcsw3vmx 64 30 FcRn FcRn NNP cord-273505-pcsw3vmx 64 31 deficient deficient JJ cord-273505-pcsw3vmx 64 32 models model NNS cord-273505-pcsw3vmx 64 33 , , , cord-273505-pcsw3vmx 64 34 indicating indicate VBG cord-273505-pcsw3vmx 64 35 that that IN cord-273505-pcsw3vmx 64 36 FcRn FcRn NNP cord-273505-pcsw3vmx 64 37 is be VBZ cord-273505-pcsw3vmx 64 38 involved involve VBN cord-273505-pcsw3vmx 64 39 in in IN cord-273505-pcsw3vmx 64 40 therapeutic therapeutic JJ cord-273505-pcsw3vmx 64 41 effects effect NNS cord-273505-pcsw3vmx 64 42 of of IN cord-273505-pcsw3vmx 64 43 IVIg ivig NN cord-273505-pcsw3vmx 64 44 therapy therapy NN cord-273505-pcsw3vmx 64 45 ( ( -LRB- cord-273505-pcsw3vmx 64 46 54 54 CD cord-273505-pcsw3vmx 64 47 , , , cord-273505-pcsw3vmx 64 48 55 55 CD cord-273505-pcsw3vmx 64 49 ) ) -RRB- cord-273505-pcsw3vmx 64 50 . . . cord-273505-pcsw3vmx 65 1 Influences influence NNS cord-273505-pcsw3vmx 65 2 of of IN cord-273505-pcsw3vmx 65 3 FcRn FcRn NNP cord-273505-pcsw3vmx 65 4 gene gene NN cord-273505-pcsw3vmx 65 5 polymorphisms polymorphism NNS cord-273505-pcsw3vmx 65 6 on on IN cord-273505-pcsw3vmx 65 7 different different JJ cord-273505-pcsw3vmx 65 8 IgG IgG NNP cord-273505-pcsw3vmx 65 9 kinetics kinetic NNS cord-273505-pcsw3vmx 65 10 and and CC cord-273505-pcsw3vmx 65 11 therapeutic therapeutic JJ cord-273505-pcsw3vmx 65 12 effects effect NNS cord-273505-pcsw3vmx 65 13 of of IN cord-273505-pcsw3vmx 65 14 IVIg ivig NN cord-273505-pcsw3vmx 65 15 among among IN cord-273505-pcsw3vmx 65 16 patients patient NNS cord-273505-pcsw3vmx 65 17 have have VBP cord-273505-pcsw3vmx 65 18 been be VBN cord-273505-pcsw3vmx 65 19 observed observe VBN cord-273505-pcsw3vmx 65 20 ( ( -LRB- cord-273505-pcsw3vmx 65 21 56 56 CD cord-273505-pcsw3vmx 65 22 ) ) -RRB- cord-273505-pcsw3vmx 65 23 ( ( -LRB- cord-273505-pcsw3vmx 65 24 57 57 CD cord-273505-pcsw3vmx 65 25 ) ) -RRB- cord-273505-pcsw3vmx 65 26 ( ( -LRB- cord-273505-pcsw3vmx 65 27 58 58 CD cord-273505-pcsw3vmx 65 28 ) ) -RRB- cord-273505-pcsw3vmx 65 29 . . . cord-273505-pcsw3vmx 66 1 Pharmacokinetic pharmacokinetic JJ cord-273505-pcsw3vmx 66 2 models model NNS cord-273505-pcsw3vmx 66 3 predicted predict VBD cord-273505-pcsw3vmx 66 4 that that IN cord-273505-pcsw3vmx 66 5 the the DT cord-273505-pcsw3vmx 66 6 therapeutic therapeutic JJ cord-273505-pcsw3vmx 66 7 effects effect NNS cord-273505-pcsw3vmx 66 8 of of IN cord-273505-pcsw3vmx 66 9 IVIg ivig NN cord-273505-pcsw3vmx 66 10 relate relate VBP cord-273505-pcsw3vmx 66 11 to to IN cord-273505-pcsw3vmx 66 12 total total JJ cord-273505-pcsw3vmx 66 13 serum serum NN cord-273505-pcsw3vmx 66 14 IgG igg NN cord-273505-pcsw3vmx 66 15 concentration concentration NN cord-273505-pcsw3vmx 66 16 and and CC cord-273505-pcsw3vmx 66 17 FcRn FcRn NNP cord-273505-pcsw3vmx 66 18 - - HYPH cord-273505-pcsw3vmx 66 19 binding bind VBG cord-273505-pcsw3vmx 66 20 capacity capacity NN cord-273505-pcsw3vmx 66 21 ( ( -LRB- cord-273505-pcsw3vmx 66 22 59 59 CD cord-273505-pcsw3vmx 66 23 ) ) -RRB- cord-273505-pcsw3vmx 66 24 . . . cord-273505-pcsw3vmx 67 1 The the DT cord-273505-pcsw3vmx 67 2 substantial substantial JJ cord-273505-pcsw3vmx 67 3 increase increase NN cord-273505-pcsw3vmx 67 4 in in IN cord-273505-pcsw3vmx 67 5 IgG igg NN cord-273505-pcsw3vmx 67 6 concentration concentration NN cord-273505-pcsw3vmx 67 7 may may MD cord-273505-pcsw3vmx 67 8 saturate saturate VB cord-273505-pcsw3vmx 67 9 FcRn FcRn NNP cord-273505-pcsw3vmx 67 10 and and CC cord-273505-pcsw3vmx 67 11 reduce reduce VB cord-273505-pcsw3vmx 67 12 the the DT cord-273505-pcsw3vmx 67 13 half half JJ cord-273505-pcsw3vmx 67 14 - - HYPH cord-273505-pcsw3vmx 67 15 life life NN cord-273505-pcsw3vmx 67 16 of of IN cord-273505-pcsw3vmx 67 17 pathogenic pathogenic JJ cord-273505-pcsw3vmx 67 18 antibodies antibody NNS cord-273505-pcsw3vmx 67 19 , , , cord-273505-pcsw3vmx 67 20 contributing contribute VBG cord-273505-pcsw3vmx 67 21 to to IN cord-273505-pcsw3vmx 67 22 the the DT cord-273505-pcsw3vmx 67 23 anti anti JJ cord-273505-pcsw3vmx 67 24 - - JJ cord-273505-pcsw3vmx 67 25 inflammatory inflammatory JJ cord-273505-pcsw3vmx 67 26 mechanism mechanism NN cord-273505-pcsw3vmx 67 27 of of IN cord-273505-pcsw3vmx 67 28 high high JJ cord-273505-pcsw3vmx 67 29 - - HYPH cord-273505-pcsw3vmx 67 30 dose dose NN cord-273505-pcsw3vmx 67 31 IVIg ivig NN cord-273505-pcsw3vmx 67 32 . . . cord-273505-pcsw3vmx 68 1 A a DT cord-273505-pcsw3vmx 68 2 balance balance NN cord-273505-pcsw3vmx 68 3 between between IN cord-273505-pcsw3vmx 68 4 activating activate VBG cord-273505-pcsw3vmx 68 5 and and CC cord-273505-pcsw3vmx 68 6 inhibitory inhibitory JJ cord-273505-pcsw3vmx 68 7 FcγRs FcγRs NNP cord-273505-pcsw3vmx 68 8 is be VBZ cord-273505-pcsw3vmx 68 9 critical critical JJ cord-273505-pcsw3vmx 68 10 for for IN cord-273505-pcsw3vmx 68 11 a a DT cord-273505-pcsw3vmx 68 12 well well RB cord-273505-pcsw3vmx 68 13 - - HYPH cord-273505-pcsw3vmx 68 14 regulated regulate VBN cord-273505-pcsw3vmx 68 15 immune immune JJ cord-273505-pcsw3vmx 68 16 response response NN cord-273505-pcsw3vmx 68 17 , , , cord-273505-pcsw3vmx 68 18 and and CC cord-273505-pcsw3vmx 68 19 a a DT cord-273505-pcsw3vmx 68 20 disbalance disbalance NN cord-273505-pcsw3vmx 68 21 markedly markedly RB cord-273505-pcsw3vmx 68 22 influences influence VBZ cord-273505-pcsw3vmx 68 23 immunopathology immunopathology NN cord-273505-pcsw3vmx 68 24 in in IN cord-273505-pcsw3vmx 68 25 autoimmune autoimmune JJ cord-273505-pcsw3vmx 68 26 and and CC cord-273505-pcsw3vmx 68 27 infectious infectious JJ cord-273505-pcsw3vmx 68 28 diseases disease NNS cord-273505-pcsw3vmx 68 29 . . . cord-273505-pcsw3vmx 69 1 FcγRIIB FcγRIIB NNP cord-273505-pcsw3vmx 69 2 is be VBZ cord-273505-pcsw3vmx 69 3 the the DT cord-273505-pcsw3vmx 69 4 only only JJ cord-273505-pcsw3vmx 69 5 ITIM ITIM NNP cord-273505-pcsw3vmx 69 6 - - HYPH cord-273505-pcsw3vmx 69 7 containing contain VBG cord-273505-pcsw3vmx 69 8 FcγR fcγr NN cord-273505-pcsw3vmx 69 9 and and CC cord-273505-pcsw3vmx 69 10 negatively negatively RB cord-273505-pcsw3vmx 69 11 regulates regulate VBZ cord-273505-pcsw3vmx 69 12 many many JJ cord-273505-pcsw3vmx 69 13 aspects aspect NNS cord-273505-pcsw3vmx 69 14 of of IN cord-273505-pcsw3vmx 69 15 immune immune JJ cord-273505-pcsw3vmx 69 16 and and CC cord-273505-pcsw3vmx 69 17 inflammatory inflammatory JJ cord-273505-pcsw3vmx 69 18 responses response NNS cord-273505-pcsw3vmx 69 19 . . . cord-273505-pcsw3vmx 70 1 After after IN cord-273505-pcsw3vmx 70 2 efficient efficient JJ cord-273505-pcsw3vmx 70 3 high high JJ cord-273505-pcsw3vmx 70 4 - - HYPH cord-273505-pcsw3vmx 70 5 dose dose NN cord-273505-pcsw3vmx 70 6 IVIg ivig NN cord-273505-pcsw3vmx 70 7 therapy therapy NN cord-273505-pcsw3vmx 70 8 , , , cord-273505-pcsw3vmx 70 9 an an DT cord-273505-pcsw3vmx 70 10 upregulation upregulation NN cord-273505-pcsw3vmx 70 11 of of IN cord-273505-pcsw3vmx 70 12 FcγRIIB fcγriib NN cord-273505-pcsw3vmx 70 13 on on IN cord-273505-pcsw3vmx 70 14 immune immune JJ cord-273505-pcsw3vmx 70 15 cells cell NNS cord-273505-pcsw3vmx 70 16 is be VBZ cord-273505-pcsw3vmx 70 17 considered consider VBN cord-273505-pcsw3vmx 70 18 to to TO cord-273505-pcsw3vmx 70 19 contribute contribute VB cord-273505-pcsw3vmx 70 20 to to IN cord-273505-pcsw3vmx 70 21 the the DT cord-273505-pcsw3vmx 70 22 anti anti JJ cord-273505-pcsw3vmx 70 23 - - JJ cord-273505-pcsw3vmx 70 24 inflammatory inflammatory JJ cord-273505-pcsw3vmx 70 25 process process NN cord-273505-pcsw3vmx 70 26 ( ( -LRB- cord-273505-pcsw3vmx 70 27 43 43 CD cord-273505-pcsw3vmx 70 28 , , , cord-273505-pcsw3vmx 70 29 60 60 CD cord-273505-pcsw3vmx 70 30 , , , cord-273505-pcsw3vmx 70 31 61 61 CD cord-273505-pcsw3vmx 70 32 ) ) -RRB- cord-273505-pcsw3vmx 70 33 . . . cord-273505-pcsw3vmx 71 1 However however RB cord-273505-pcsw3vmx 71 2 , , , cord-273505-pcsw3vmx 71 3 evidence evidence NN cord-273505-pcsw3vmx 71 4 of of IN cord-273505-pcsw3vmx 71 5 underlying underlie VBG cord-273505-pcsw3vmx 71 6 molecular molecular JJ cord-273505-pcsw3vmx 71 7 mechanisms mechanism NNS cord-273505-pcsw3vmx 71 8 remains remain VBZ cord-273505-pcsw3vmx 71 9 sparse sparse JJ cord-273505-pcsw3vmx 71 10 and and CC cord-273505-pcsw3vmx 71 11 this this DT cord-273505-pcsw3vmx 71 12 mechanism mechanism NN cord-273505-pcsw3vmx 71 13 of of IN cord-273505-pcsw3vmx 71 14 therapeutic therapeutic JJ cord-273505-pcsw3vmx 71 15 action action NN cord-273505-pcsw3vmx 71 16 is be VBZ cord-273505-pcsw3vmx 71 17 therefore therefore RB cord-273505-pcsw3vmx 71 18 controversial controversial JJ cord-273505-pcsw3vmx 71 19 . . . cord-273505-pcsw3vmx 72 1 In in IN cord-273505-pcsw3vmx 72 2 the the DT cord-273505-pcsw3vmx 72 3 last last JJ cord-273505-pcsw3vmx 72 4 decade decade NN cord-273505-pcsw3vmx 72 5 , , , cord-273505-pcsw3vmx 72 6 a a DT cord-273505-pcsw3vmx 72 7 prevailing prevail VBG cord-273505-pcsw3vmx 72 8 theory theory NN cord-273505-pcsw3vmx 72 9 from from IN cord-273505-pcsw3vmx 72 10 murine murine JJ cord-273505-pcsw3vmx 72 11 studies study NNS cord-273505-pcsw3vmx 72 12 argued argue VBD cord-273505-pcsw3vmx 72 13 that that IN cord-273505-pcsw3vmx 72 14 a a DT cord-273505-pcsw3vmx 72 15 minor minor JJ cord-273505-pcsw3vmx 72 16 portion portion NN cord-273505-pcsw3vmx 72 17 of of IN cord-273505-pcsw3vmx 72 18 IgG igg NN cord-273505-pcsw3vmx 72 19 , , , cord-273505-pcsw3vmx 72 20 with with IN cord-273505-pcsw3vmx 72 21 specific specific JJ cord-273505-pcsw3vmx 72 22 sialylation sialylation NN cord-273505-pcsw3vmx 72 23 of of IN cord-273505-pcsw3vmx 72 24 the the DT cord-273505-pcsw3vmx 72 25 Asn297-linked Asn297-linked NNP cord-273505-pcsw3vmx 72 26 glycan glycan NN cord-273505-pcsw3vmx 72 27 structure structure NN cord-273505-pcsw3vmx 72 28 on on IN cord-273505-pcsw3vmx 72 29 the the DT cord-273505-pcsw3vmx 72 30 Fc Fc NNP cord-273505-pcsw3vmx 72 31 fragment fragment NN cord-273505-pcsw3vmx 72 32 , , , cord-273505-pcsw3vmx 72 33 is be VBZ cord-273505-pcsw3vmx 72 34 essential essential JJ cord-273505-pcsw3vmx 72 35 for for IN cord-273505-pcsw3vmx 72 36 anti anti JJ cord-273505-pcsw3vmx 72 37 - - JJ cord-273505-pcsw3vmx 72 38 inflammatory inflammatory JJ cord-273505-pcsw3vmx 72 39 activities activity NNS cord-273505-pcsw3vmx 72 40 of of IN cord-273505-pcsw3vmx 72 41 IVIg ivig NN cord-273505-pcsw3vmx 72 42 via via IN cord-273505-pcsw3vmx 72 43 direct direct JJ cord-273505-pcsw3vmx 72 44 interaction interaction NN cord-273505-pcsw3vmx 72 45 with with IN cord-273505-pcsw3vmx 72 46 myeloid myeloid JJ cord-273505-pcsw3vmx 72 47 regulatory regulatory JJ cord-273505-pcsw3vmx 72 48 cells cell NNS cord-273505-pcsw3vmx 72 49 expressing express VBG cord-273505-pcsw3vmx 72 50 SIGN sign NN cord-273505-pcsw3vmx 72 51 - - HYPH cord-273505-pcsw3vmx 72 52 R1 r1 NN cord-273505-pcsw3vmx 72 53 ( ( -LRB- cord-273505-pcsw3vmx 72 54 mice mouse NNS cord-273505-pcsw3vmx 72 55 ) ) -RRB- cord-273505-pcsw3vmx 72 56 or or CC cord-273505-pcsw3vmx 72 57 DC DC NNP cord-273505-pcsw3vmx 72 58 - - HYPH cord-273505-pcsw3vmx 72 59 SIGN sign NN cord-273505-pcsw3vmx 72 60 ( ( -LRB- cord-273505-pcsw3vmx 72 61 human human NN cord-273505-pcsw3vmx 72 62 ) ) -RRB- cord-273505-pcsw3vmx 72 63 ( ( -LRB- cord-273505-pcsw3vmx 72 64 44 44 CD cord-273505-pcsw3vmx 72 65 , , , cord-273505-pcsw3vmx 72 66 62 62 CD cord-273505-pcsw3vmx 72 67 , , , cord-273505-pcsw3vmx 72 68 63 63 CD cord-273505-pcsw3vmx 72 69 ) ) -RRB- cord-273505-pcsw3vmx 72 70 . . . cord-273505-pcsw3vmx 73 1 Subsequent subsequent JJ cord-273505-pcsw3vmx 73 2 research research NN cord-273505-pcsw3vmx 73 3 revealed reveal VBD cord-273505-pcsw3vmx 73 4 that that IN cord-273505-pcsw3vmx 73 5 administration administration NN cord-273505-pcsw3vmx 73 6 of of IN cord-273505-pcsw3vmx 73 7 sialylated sialylated NNP cord-273505-pcsw3vmx 73 8 IgG IgG NNP cord-273505-pcsw3vmx 73 9 resulted result VBD cord-273505-pcsw3vmx 73 10 in in IN cord-273505-pcsw3vmx 73 11 the the DT cord-273505-pcsw3vmx 73 12 production production NN cord-273505-pcsw3vmx 73 13 of of IN cord-273505-pcsw3vmx 73 14 IL-33 IL-33 NNP cord-273505-pcsw3vmx 73 15 from from IN cord-273505-pcsw3vmx 73 16 hDC hDC NNP cord-273505-pcsw3vmx 73 17 - - HYPH cord-273505-pcsw3vmx 73 18 SIGN sign NN cord-273505-pcsw3vmx 73 19 + + CC cord-273505-pcsw3vmx 73 20 macrophages macrophage NNS cord-273505-pcsw3vmx 73 21 or or CC cord-273505-pcsw3vmx 73 22 dendritic dendritic JJ cord-273505-pcsw3vmx 73 23 cells cell NNS cord-273505-pcsw3vmx 73 24 and and CC cord-273505-pcsw3vmx 73 25 ensuing ensue VBG cord-273505-pcsw3vmx 73 26 expansion expansion NN cord-273505-pcsw3vmx 73 27 of of IN cord-273505-pcsw3vmx 73 28 IL-4-producing il-4-produce VBG cord-273505-pcsw3vmx 73 29 basophils basophil NNS cord-273505-pcsw3vmx 73 30 , , , cord-273505-pcsw3vmx 73 31 and and CC cord-273505-pcsw3vmx 73 32 these these DT cord-273505-pcsw3vmx 73 33 cytokines cytokine NNS cord-273505-pcsw3vmx 73 34 led lead VBD cord-273505-pcsw3vmx 73 35 to to IN cord-273505-pcsw3vmx 73 36 FcγRIIB FcγRIIB NNP cord-273505-pcsw3vmx 73 37 expression expression NN cord-273505-pcsw3vmx 73 38 on on IN cord-273505-pcsw3vmx 73 39 effector effector NN cord-273505-pcsw3vmx 73 40 cells cell NNS cord-273505-pcsw3vmx 73 41 ( ( -LRB- cord-273505-pcsw3vmx 73 42 64 64 CD cord-273505-pcsw3vmx 73 43 , , , cord-273505-pcsw3vmx 73 44 65 65 CD cord-273505-pcsw3vmx 73 45 ) ) -RRB- cord-273505-pcsw3vmx 73 46 . . . cord-273505-pcsw3vmx 74 1 However however RB cord-273505-pcsw3vmx 74 2 , , , cord-273505-pcsw3vmx 74 3 other other JJ cord-273505-pcsw3vmx 74 4 studies study NNS cord-273505-pcsw3vmx 74 5 have have VBP cord-273505-pcsw3vmx 74 6 challenged challenge VBN cord-273505-pcsw3vmx 74 7 this this DT cord-273505-pcsw3vmx 74 8 hypothesis hypothesis NN cord-273505-pcsw3vmx 74 9 . . . cord-273505-pcsw3vmx 75 1 The the DT cord-273505-pcsw3vmx 75 2 evidence evidence NN cord-273505-pcsw3vmx 75 3 of of IN cord-273505-pcsw3vmx 75 4 a a DT cord-273505-pcsw3vmx 75 5 direct direct JJ cord-273505-pcsw3vmx 75 6 interaction interaction NN cord-273505-pcsw3vmx 75 7 between between IN cord-273505-pcsw3vmx 75 8 sialylated sialylated JJ cord-273505-pcsw3vmx 75 9 IgG IgG NNP cord-273505-pcsw3vmx 75 10 and and CC cord-273505-pcsw3vmx 75 11 DC DC NNP cord-273505-pcsw3vmx 75 12 - - HYPH cord-273505-pcsw3vmx 75 13 SIGN SIGN NNP cord-273505-pcsw3vmx 75 14 is be VBZ cord-273505-pcsw3vmx 75 15 not not RB cord-273505-pcsw3vmx 75 16 fully fully RB cord-273505-pcsw3vmx 75 17 supported support VBN cord-273505-pcsw3vmx 75 18 in in IN cord-273505-pcsw3vmx 75 19 the the DT cord-273505-pcsw3vmx 75 20 literature literature NN cord-273505-pcsw3vmx 75 21 ( ( -LRB- cord-273505-pcsw3vmx 75 22 66 66 CD cord-273505-pcsw3vmx 75 23 , , , cord-273505-pcsw3vmx 75 24 67 67 CD cord-273505-pcsw3vmx 75 25 ) ) -RRB- cord-273505-pcsw3vmx 75 26 . . . cord-273505-pcsw3vmx 76 1 Moreover moreover RB cord-273505-pcsw3vmx 76 2 , , , cord-273505-pcsw3vmx 76 3 there there EX cord-273505-pcsw3vmx 76 4 is be VBZ cord-273505-pcsw3vmx 76 5 conflicting conflict VBG cord-273505-pcsw3vmx 76 6 evidence evidence NN cord-273505-pcsw3vmx 76 7 suggesting suggest VBG cord-273505-pcsw3vmx 76 8 that that IN cord-273505-pcsw3vmx 76 9 the the DT cord-273505-pcsw3vmx 76 10 sialylated sialylated JJ cord-273505-pcsw3vmx 76 11 Fc Fc NNP cord-273505-pcsw3vmx 76 12 fragment fragment NN cord-273505-pcsw3vmx 76 13 of of IN cord-273505-pcsw3vmx 76 14 IgG IgG NNP cord-273505-pcsw3vmx 76 15 is be VBZ cord-273505-pcsw3vmx 76 16 dispensable dispensable JJ cord-273505-pcsw3vmx 76 17 for for IN cord-273505-pcsw3vmx 76 18 the the DT cord-273505-pcsw3vmx 76 19 anti anti JJ cord-273505-pcsw3vmx 76 20 - - JJ cord-273505-pcsw3vmx 76 21 inflammatory inflammatory JJ cord-273505-pcsw3vmx 76 22 mechanisms mechanism NNS cord-273505-pcsw3vmx 76 23 of of IN cord-273505-pcsw3vmx 76 24 high high JJ cord-273505-pcsw3vmx 76 25 - - HYPH cord-273505-pcsw3vmx 76 26 dose dose NN cord-273505-pcsw3vmx 76 27 IVIg IVIg NNS cord-273505-pcsw3vmx 76 28 ( ( -LRB- cord-273505-pcsw3vmx 76 29 68 68 CD cord-273505-pcsw3vmx 76 30 ) ) -RRB- cord-273505-pcsw3vmx 76 31 ( ( -LRB- cord-273505-pcsw3vmx 76 32 69 69 CD cord-273505-pcsw3vmx 76 33 ) ) -RRB- cord-273505-pcsw3vmx 76 34 ( ( -LRB- cord-273505-pcsw3vmx 76 35 70 70 CD cord-273505-pcsw3vmx 76 36 ) ) -RRB- cord-273505-pcsw3vmx 76 37 ( ( -LRB- cord-273505-pcsw3vmx 76 38 71 71 CD cord-273505-pcsw3vmx 76 39 ) ) -RRB- cord-273505-pcsw3vmx 76 40 ( ( -LRB- cord-273505-pcsw3vmx 76 41 72 72 CD cord-273505-pcsw3vmx 76 42 ) ) -RRB- cord-273505-pcsw3vmx 76 43 . . . cord-273505-pcsw3vmx 77 1 It -PRON- PRP cord-273505-pcsw3vmx 77 2 should should MD cord-273505-pcsw3vmx 77 3 be be VB cord-273505-pcsw3vmx 77 4 noted note VBN cord-273505-pcsw3vmx 77 5 that that IN cord-273505-pcsw3vmx 77 6 all all DT cord-273505-pcsw3vmx 77 7 evidence evidence NN cord-273505-pcsw3vmx 77 8 of of IN cord-273505-pcsw3vmx 77 9 this this DT cord-273505-pcsw3vmx 77 10 hypothesis hypothesis NN cord-273505-pcsw3vmx 77 11 derives derive VBZ cord-273505-pcsw3vmx 77 12 from from IN cord-273505-pcsw3vmx 77 13 murine murine JJ cord-273505-pcsw3vmx 77 14 studies study NNS cord-273505-pcsw3vmx 77 15 , , , cord-273505-pcsw3vmx 77 16 which which WDT cord-273505-pcsw3vmx 77 17 might may MD cord-273505-pcsw3vmx 77 18 not not RB cord-273505-pcsw3vmx 77 19 be be VB cord-273505-pcsw3vmx 77 20 readily readily RB cord-273505-pcsw3vmx 77 21 translated translate VBN cord-273505-pcsw3vmx 77 22 to to IN cord-273505-pcsw3vmx 77 23 human human JJ cord-273505-pcsw3vmx 77 24 conditions condition NNS cord-273505-pcsw3vmx 77 25 . . . cord-273505-pcsw3vmx 78 1 These these DT cord-273505-pcsw3vmx 78 2 controversial controversial JJ cord-273505-pcsw3vmx 78 3 results result NNS cord-273505-pcsw3vmx 78 4 warrant warrant VBP cord-273505-pcsw3vmx 78 5 further further JJ cord-273505-pcsw3vmx 78 6 research research NN cord-273505-pcsw3vmx 78 7 to to TO cord-273505-pcsw3vmx 78 8 address address VB cord-273505-pcsw3vmx 78 9 the the DT cord-273505-pcsw3vmx 78 10 mechanisms mechanism NNS cord-273505-pcsw3vmx 78 11 and and CC cord-273505-pcsw3vmx 78 12 molecular molecular JJ cord-273505-pcsw3vmx 78 13 basis basis NN cord-273505-pcsw3vmx 78 14 of of IN cord-273505-pcsw3vmx 78 15 high high JJ cord-273505-pcsw3vmx 78 16 - - HYPH cord-273505-pcsw3vmx 78 17 dose dose NN cord-273505-pcsw3vmx 78 18 IVIg ivig JJ cord-273505-pcsw3vmx 78 19 upregulation upregulation NN cord-273505-pcsw3vmx 78 20 of of IN cord-273505-pcsw3vmx 78 21 the the DT cord-273505-pcsw3vmx 78 22 inhibitory inhibitory JJ cord-273505-pcsw3vmx 78 23 FcγRIIB fcγriib NN cord-273505-pcsw3vmx 78 24 . . . cord-273505-pcsw3vmx 79 1 The the DT cord-273505-pcsw3vmx 79 2 complement complement NN cord-273505-pcsw3vmx 79 3 system system NN cord-273505-pcsw3vmx 79 4 is be VBZ cord-273505-pcsw3vmx 79 5 activated activate VBN cord-273505-pcsw3vmx 79 6 through through IN cord-273505-pcsw3vmx 79 7 three three CD cord-273505-pcsw3vmx 79 8 pathways pathway NNS cord-273505-pcsw3vmx 79 9 , , , cord-273505-pcsw3vmx 79 10 namely namely RB cord-273505-pcsw3vmx 79 11 the the DT cord-273505-pcsw3vmx 79 12 classical classical JJ cord-273505-pcsw3vmx 79 13 pathway pathway NN cord-273505-pcsw3vmx 79 14 , , , cord-273505-pcsw3vmx 79 15 the the DT cord-273505-pcsw3vmx 79 16 lectin lectin NN cord-273505-pcsw3vmx 79 17 pathway pathway NN cord-273505-pcsw3vmx 79 18 , , , cord-273505-pcsw3vmx 79 19 and and CC cord-273505-pcsw3vmx 79 20 the the DT cord-273505-pcsw3vmx 79 21 alternative alternative JJ cord-273505-pcsw3vmx 79 22 pathway pathway NN cord-273505-pcsw3vmx 79 23 . . . cord-273505-pcsw3vmx 80 1 Besides besides IN cord-273505-pcsw3vmx 80 2 the the DT cord-273505-pcsw3vmx 80 3 F(ab f(ab NN cord-273505-pcsw3vmx 80 4 ) ) -RRB- cord-273505-pcsw3vmx 80 5 ′ ′ CD cord-273505-pcsw3vmx 80 6 2 2 CD cord-273505-pcsw3vmx 80 7 -mediated -mediated JJ cord-273505-pcsw3vmx 80 8 neutralization neutralization NN cord-273505-pcsw3vmx 80 9 of of IN cord-273505-pcsw3vmx 80 10 complement complement JJ cord-273505-pcsw3vmx 80 11 C3a C3a NNS cord-273505-pcsw3vmx 80 12 and and CC cord-273505-pcsw3vmx 80 13 C5a C5a NNS cord-273505-pcsw3vmx 80 14 , , , cord-273505-pcsw3vmx 80 15 the the DT cord-273505-pcsw3vmx 80 16 interaction interaction NN cord-273505-pcsw3vmx 80 17 between between IN cord-273505-pcsw3vmx 80 18 the the DT cord-273505-pcsw3vmx 80 19 Fc Fc NNP cord-273505-pcsw3vmx 80 20 fragment fragment NN cord-273505-pcsw3vmx 80 21 and and CC cord-273505-pcsw3vmx 80 22 complement complement VB cord-273505-pcsw3vmx 80 23 C1q C1q NNP cord-273505-pcsw3vmx 80 24 , , , cord-273505-pcsw3vmx 80 25 C3b C3b NNP cord-273505-pcsw3vmx 80 26 , , , cord-273505-pcsw3vmx 80 27 and and CC cord-273505-pcsw3vmx 80 28 C4b c4b NN cord-273505-pcsw3vmx 80 29 in in IN cord-273505-pcsw3vmx 80 30 a a DT cord-273505-pcsw3vmx 80 31 dosedependent dosedependent NN cord-273505-pcsw3vmx 80 32 manner manner NN cord-273505-pcsw3vmx 80 33 , , , cord-273505-pcsw3vmx 80 34 contributes contribute VBZ cord-273505-pcsw3vmx 80 35 to to IN cord-273505-pcsw3vmx 80 36 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 80 37 effects effect NNS cord-273505-pcsw3vmx 80 38 of of IN cord-273505-pcsw3vmx 80 39 IVIg ivig NN cord-273505-pcsw3vmx 80 40 on on IN cord-273505-pcsw3vmx 80 41 the the DT cord-273505-pcsw3vmx 80 42 classical classical JJ cord-273505-pcsw3vmx 80 43 complement complement NN cord-273505-pcsw3vmx 80 44 pathway pathway NN cord-273505-pcsw3vmx 80 45 ( ( -LRB- cord-273505-pcsw3vmx 80 46 73 73 CD cord-273505-pcsw3vmx 80 47 ) ) -RRB- cord-273505-pcsw3vmx 80 48 ( ( -LRB- cord-273505-pcsw3vmx 80 49 74 74 CD cord-273505-pcsw3vmx 80 50 ) ) -RRB- cord-273505-pcsw3vmx 80 51 ( ( -LRB- cord-273505-pcsw3vmx 80 52 75 75 CD cord-273505-pcsw3vmx 80 53 ) ) -RRB- cord-273505-pcsw3vmx 80 54 . . . cord-273505-pcsw3vmx 81 1 The the DT cord-273505-pcsw3vmx 81 2 binding binding NN cord-273505-pcsw3vmx 81 3 site site NN cord-273505-pcsw3vmx 81 4 of of IN cord-273505-pcsw3vmx 81 5 C3b c3b NN cord-273505-pcsw3vmx 81 6 / / SYM cord-273505-pcsw3vmx 81 7 C4b c4b NN cord-273505-pcsw3vmx 81 8 is be VBZ cord-273505-pcsw3vmx 81 9 located locate VBN cord-273505-pcsw3vmx 81 10 on on IN cord-273505-pcsw3vmx 81 11 the the DT cord-273505-pcsw3vmx 81 12 residues residue NNS cord-273505-pcsw3vmx 81 13 381 381 CD cord-273505-pcsw3vmx 81 14 - - SYM cord-273505-pcsw3vmx 81 15 390 390 CD cord-273505-pcsw3vmx 81 16 of of IN cord-273505-pcsw3vmx 81 17 the the DT cord-273505-pcsw3vmx 81 18 CH3 CH3 NNP cord-273505-pcsw3vmx 81 19 domain domain NN cord-273505-pcsw3vmx 81 20 of of IN cord-273505-pcsw3vmx 81 21 the the DT cord-273505-pcsw3vmx 81 22 IgG IgG NNP cord-273505-pcsw3vmx 81 23 Fc Fc NNP cord-273505-pcsw3vmx 81 24 fragment fragment NN cord-273505-pcsw3vmx 81 25 , , , cord-273505-pcsw3vmx 81 26 while while IN cord-273505-pcsw3vmx 81 27 the the DT cord-273505-pcsw3vmx 81 28 residues residue NNS cord-273505-pcsw3vmx 81 29 318 318 CD cord-273505-pcsw3vmx 81 30 - - SYM cord-273505-pcsw3vmx 81 31 322 322 CD cord-273505-pcsw3vmx 81 32 of of IN cord-273505-pcsw3vmx 81 33 the the DT cord-273505-pcsw3vmx 81 34 CH2 CH2 NNP cord-273505-pcsw3vmx 81 35 domain domain NN cord-273505-pcsw3vmx 81 36 are be VBP cord-273505-pcsw3vmx 81 37 responsible responsible JJ cord-273505-pcsw3vmx 81 38 for for IN cord-273505-pcsw3vmx 81 39 the the DT cord-273505-pcsw3vmx 81 40 binding binding NN cord-273505-pcsw3vmx 81 41 of of IN cord-273505-pcsw3vmx 81 42 C1q C1q NNP cord-273505-pcsw3vmx 81 43 ( ( -LRB- cord-273505-pcsw3vmx 81 44 76 76 CD cord-273505-pcsw3vmx 81 45 , , , cord-273505-pcsw3vmx 81 46 77 77 CD cord-273505-pcsw3vmx 81 47 ) ) -RRB- cord-273505-pcsw3vmx 81 48 . . . cord-273505-pcsw3vmx 82 1 The the DT cord-273505-pcsw3vmx 82 2 binding bind VBG cord-273505-pcsw3vmx 82 3 domains domain NNS cord-273505-pcsw3vmx 82 4 may may MD cord-273505-pcsw3vmx 82 5 react react VB cord-273505-pcsw3vmx 82 6 with with IN cord-273505-pcsw3vmx 82 7 different different JJ cord-273505-pcsw3vmx 82 8 N n CD cord-273505-pcsw3vmx 82 9 - - HYPH cord-273505-pcsw3vmx 82 10 glycan glycan NN cord-273505-pcsw3vmx 82 11 sialylation sialylation NN cord-273505-pcsw3vmx 82 12 patterns pattern NNS cord-273505-pcsw3vmx 82 13 on on IN cord-273505-pcsw3vmx 82 14 the the DT cord-273505-pcsw3vmx 82 15 IgG IgG NNP cord-273505-pcsw3vmx 82 16 structure structure NN cord-273505-pcsw3vmx 82 17 and and CC cord-273505-pcsw3vmx 82 18 result result VB cord-273505-pcsw3vmx 82 19 in in IN cord-273505-pcsw3vmx 82 20 distinct distinct JJ cord-273505-pcsw3vmx 82 21 anti anti JJ cord-273505-pcsw3vmx 82 22 - - JJ cord-273505-pcsw3vmx 82 23 inflammatory inflammatory JJ cord-273505-pcsw3vmx 82 24 effects effect NNS cord-273505-pcsw3vmx 82 25 through through IN cord-273505-pcsw3vmx 82 26 the the DT cord-273505-pcsw3vmx 82 27 complement complement NN cord-273505-pcsw3vmx 82 28 pathway pathway NN cord-273505-pcsw3vmx 82 29 ( ( -LRB- cord-273505-pcsw3vmx 82 30 78 78 CD cord-273505-pcsw3vmx 82 31 ) ) -RRB- cord-273505-pcsw3vmx 82 32 . . . cord-273505-pcsw3vmx 83 1 As as IN cord-273505-pcsw3vmx 83 2 an an DT cord-273505-pcsw3vmx 83 3 extremely extremely RB cord-273505-pcsw3vmx 83 4 complex complex JJ cord-273505-pcsw3vmx 83 5 preparation preparation NN cord-273505-pcsw3vmx 83 6 , , , cord-273505-pcsw3vmx 83 7 IVIg IVIg NNP cord-273505-pcsw3vmx 83 8 contains contain VBZ cord-273505-pcsw3vmx 83 9 a a DT cord-273505-pcsw3vmx 83 10 large large JJ cord-273505-pcsw3vmx 83 11 number number NN cord-273505-pcsw3vmx 83 12 of of IN cord-273505-pcsw3vmx 83 13 bioactive bioactive JJ cord-273505-pcsw3vmx 83 14 moieties moiety NNS cord-273505-pcsw3vmx 83 15 , , , cord-273505-pcsw3vmx 83 16 and and CC cord-273505-pcsw3vmx 83 17 the the DT cord-273505-pcsw3vmx 83 18 entirety entirety NN cord-273505-pcsw3vmx 83 19 of of IN cord-273505-pcsw3vmx 83 20 effects effect NNS cord-273505-pcsw3vmx 83 21 from from IN cord-273505-pcsw3vmx 83 22 IVIg IVIg NNP cord-273505-pcsw3vmx 83 23 is be VBZ cord-273505-pcsw3vmx 83 24 therefore therefore RB cord-273505-pcsw3vmx 83 25 not not RB cord-273505-pcsw3vmx 83 26 fully fully RB cord-273505-pcsw3vmx 83 27 understood understand VBN cord-273505-pcsw3vmx 83 28 yet yet RB cord-273505-pcsw3vmx 83 29 . . . cord-273505-pcsw3vmx 84 1 The the DT cord-273505-pcsw3vmx 84 2 proposed propose VBN cord-273505-pcsw3vmx 84 3 antigen antigen NN cord-273505-pcsw3vmx 84 4 - - HYPH cord-273505-pcsw3vmx 84 5 specific specific JJ cord-273505-pcsw3vmx 84 6 F(ab f(ab NN cord-273505-pcsw3vmx 84 7 ) ) -RRB- cord-273505-pcsw3vmx 84 8 ′ ′ CD cord-273505-pcsw3vmx 84 9 2 2 CD cord-273505-pcsw3vmx 84 10 -mediated -mediated JJ cord-273505-pcsw3vmx 84 11 mechanisms mechanism NNS cord-273505-pcsw3vmx 84 12 and and CC cord-273505-pcsw3vmx 84 13 unspecific unspecific JJ cord-273505-pcsw3vmx 84 14 Fc Fc NNP cord-273505-pcsw3vmx 84 15 - - HYPH cord-273505-pcsw3vmx 84 16 mediated mediate VBN cord-273505-pcsw3vmx 84 17 mechanisms mechanism NNS cord-273505-pcsw3vmx 84 18 are be VBP cord-273505-pcsw3vmx 84 19 not not RB cord-273505-pcsw3vmx 84 20 mutually mutually RB cord-273505-pcsw3vmx 84 21 exclusive exclusive JJ cord-273505-pcsw3vmx 84 22 , , , cord-273505-pcsw3vmx 84 23 but but CC cord-273505-pcsw3vmx 84 24 is be VBZ cord-273505-pcsw3vmx 84 25 more more RBR cord-273505-pcsw3vmx 84 26 likely likely JJ cord-273505-pcsw3vmx 84 27 to to TO cord-273505-pcsw3vmx 84 28 regulate regulate VB cord-273505-pcsw3vmx 84 29 the the DT cord-273505-pcsw3vmx 84 30 immune immune JJ cord-273505-pcsw3vmx 84 31 system system NN cord-273505-pcsw3vmx 84 32 in in IN cord-273505-pcsw3vmx 84 33 synergy synergy NN cord-273505-pcsw3vmx 84 34 , , , cord-273505-pcsw3vmx 84 35 giving give VBG cord-273505-pcsw3vmx 84 36 rise rise NN cord-273505-pcsw3vmx 84 37 to to IN cord-273505-pcsw3vmx 84 38 the the DT cord-273505-pcsw3vmx 84 39 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 84 40 effects effect NNS cord-273505-pcsw3vmx 84 41 of of IN cord-273505-pcsw3vmx 84 42 high high JJ cord-273505-pcsw3vmx 84 43 - - HYPH cord-273505-pcsw3vmx 84 44 dose dose NN cord-273505-pcsw3vmx 84 45 IVIg ivig NN cord-273505-pcsw3vmx 84 46 in in IN cord-273505-pcsw3vmx 84 47 specific specific JJ cord-273505-pcsw3vmx 84 48 clinical clinical JJ cord-273505-pcsw3vmx 84 49 settings setting NNS cord-273505-pcsw3vmx 84 50 . . . cord-273505-pcsw3vmx 85 1 Although although IN cord-273505-pcsw3vmx 85 2 an an DT cord-273505-pcsw3vmx 85 3 active active JJ cord-273505-pcsw3vmx 85 4 immune immune JJ cord-273505-pcsw3vmx 85 5 response response NN cord-273505-pcsw3vmx 85 6 is be VBZ cord-273505-pcsw3vmx 85 7 essential essential JJ cord-273505-pcsw3vmx 85 8 for for IN cord-273505-pcsw3vmx 85 9 pathogen pathogen NN cord-273505-pcsw3vmx 85 10 elimination elimination NN cord-273505-pcsw3vmx 85 11 in in IN cord-273505-pcsw3vmx 85 12 acute acute JJ cord-273505-pcsw3vmx 85 13 respiratory respiratory JJ cord-273505-pcsw3vmx 85 14 viral viral JJ cord-273505-pcsw3vmx 85 15 infections infection NNS cord-273505-pcsw3vmx 85 16 , , , cord-273505-pcsw3vmx 85 17 excessive excessive JJ cord-273505-pcsw3vmx 85 18 defensive defensive JJ cord-273505-pcsw3vmx 85 19 reactions reaction NNS cord-273505-pcsw3vmx 85 20 might may MD cord-273505-pcsw3vmx 85 21 wreak wreak VB cord-273505-pcsw3vmx 85 22 havoc havoc NN cord-273505-pcsw3vmx 85 23 on on IN cord-273505-pcsw3vmx 85 24 healthy healthy JJ cord-273505-pcsw3vmx 85 25 cells cell NNS cord-273505-pcsw3vmx 85 26 and and CC cord-273505-pcsw3vmx 85 27 tissues tissue NNS cord-273505-pcsw3vmx 85 28 . . . cord-273505-pcsw3vmx 86 1 Complications complication NNS cord-273505-pcsw3vmx 86 2 or or CC cord-273505-pcsw3vmx 86 3 mortality mortality NN cord-273505-pcsw3vmx 86 4 of of IN cord-273505-pcsw3vmx 86 5 respiratory respiratory JJ cord-273505-pcsw3vmx 86 6 viral viral JJ cord-273505-pcsw3vmx 86 7 infections infection NNS cord-273505-pcsw3vmx 86 8 are be VBP cord-273505-pcsw3vmx 86 9 often often RB cord-273505-pcsw3vmx 86 10 associated associate VBN cord-273505-pcsw3vmx 86 11 with with IN cord-273505-pcsw3vmx 86 12 excessive excessive JJ cord-273505-pcsw3vmx 86 13 production production NN cord-273505-pcsw3vmx 86 14 of of IN cord-273505-pcsw3vmx 86 15 proinflammatory proinflammatory JJ cord-273505-pcsw3vmx 86 16 cytokines cytokine NNS cord-273505-pcsw3vmx 86 17 and and CC cord-273505-pcsw3vmx 86 18 ensuing ensue VBG cord-273505-pcsw3vmx 86 19 multiple multiple JJ cord-273505-pcsw3vmx 86 20 organ organ NN cord-273505-pcsw3vmx 86 21 dysfunction dysfunction NN cord-273505-pcsw3vmx 86 22 . . . cord-273505-pcsw3vmx 87 1 Although although IN cord-273505-pcsw3vmx 87 2 the the DT cord-273505-pcsw3vmx 87 3 immunopathogenesis immunopathogenesis NN cord-273505-pcsw3vmx 87 4 of of IN cord-273505-pcsw3vmx 87 5 SARS SARS NNP cord-273505-pcsw3vmx 87 6 - - HYPH cord-273505-pcsw3vmx 87 7 CoV-2 CoV-2 NNP cord-273505-pcsw3vmx 87 8 has have VBZ cord-273505-pcsw3vmx 87 9 not not RB cord-273505-pcsw3vmx 87 10 yet yet RB cord-273505-pcsw3vmx 87 11 been be VBN cord-273505-pcsw3vmx 87 12 fully fully RB cord-273505-pcsw3vmx 87 13 described describe VBN cord-273505-pcsw3vmx 87 14 , , , cord-273505-pcsw3vmx 87 15 the the DT cord-273505-pcsw3vmx 87 16 histopathological histopathological JJ cord-273505-pcsw3vmx 87 17 evidence evidence NN cord-273505-pcsw3vmx 87 18 strongly strongly RB cord-273505-pcsw3vmx 87 19 suggests suggest VBZ cord-273505-pcsw3vmx 87 20 a a DT cord-273505-pcsw3vmx 87 21 critical critical JJ cord-273505-pcsw3vmx 87 22 role role NN cord-273505-pcsw3vmx 87 23 of of IN cord-273505-pcsw3vmx 87 24 an an DT cord-273505-pcsw3vmx 87 25 excessive excessive JJ cord-273505-pcsw3vmx 87 26 immune immune JJ cord-273505-pcsw3vmx 87 27 response response NN cord-273505-pcsw3vmx 87 28 in in IN cord-273505-pcsw3vmx 87 29 mediating mediate VBG cord-273505-pcsw3vmx 87 30 extensive extensive JJ cord-273505-pcsw3vmx 87 31 damage damage NN cord-273505-pcsw3vmx 87 32 of of IN cord-273505-pcsw3vmx 87 33 the the DT cord-273505-pcsw3vmx 87 34 lung lung NN cord-273505-pcsw3vmx 87 35 and and CC cord-273505-pcsw3vmx 87 36 other other JJ cord-273505-pcsw3vmx 87 37 organs organ NNS cord-273505-pcsw3vmx 87 38 , , , cord-273505-pcsw3vmx 87 39 similar similar JJ cord-273505-pcsw3vmx 87 40 to to IN cord-273505-pcsw3vmx 87 41 previous previous JJ cord-273505-pcsw3vmx 87 42 observations observation NNS cord-273505-pcsw3vmx 87 43 in in IN cord-273505-pcsw3vmx 87 44 SARS SARS NNP cord-273505-pcsw3vmx 87 45 , , , cord-273505-pcsw3vmx 87 46 MERS MERS NNP cord-273505-pcsw3vmx 87 47 , , , cord-273505-pcsw3vmx 87 48 influenza influenza NN cord-273505-pcsw3vmx 87 49 , , , cord-273505-pcsw3vmx 87 50 and and CC cord-273505-pcsw3vmx 87 51 RSV RSV NNP cord-273505-pcsw3vmx 87 52 disease disease NN cord-273505-pcsw3vmx 87 53 , , , cord-273505-pcsw3vmx 87 54 where where WRB cord-273505-pcsw3vmx 87 55 hyper hyper JJ cord-273505-pcsw3vmx 87 56 - - JJ cord-273505-pcsw3vmx 87 57 inflammatory inflammatory JJ cord-273505-pcsw3vmx 87 58 responses response NNS cord-273505-pcsw3vmx 87 59 have have VBP cord-273505-pcsw3vmx 87 60 been be VBN cord-273505-pcsw3vmx 87 61 shown show VBN cord-273505-pcsw3vmx 87 62 to to TO cord-273505-pcsw3vmx 87 63 be be VB cord-273505-pcsw3vmx 87 64 involved involve VBN cord-273505-pcsw3vmx 87 65 in in IN cord-273505-pcsw3vmx 87 66 the the DT cord-273505-pcsw3vmx 87 67 lung lung NN cord-273505-pcsw3vmx 87 68 pathology pathology NN cord-273505-pcsw3vmx 87 69 . . . cord-273505-pcsw3vmx 88 1 In in IN cord-273505-pcsw3vmx 88 2 this this DT cord-273505-pcsw3vmx 88 3 section section NN cord-273505-pcsw3vmx 88 4 , , , cord-273505-pcsw3vmx 88 5 we -PRON- PRP cord-273505-pcsw3vmx 88 6 review review VBP cord-273505-pcsw3vmx 88 7 how how WRB cord-273505-pcsw3vmx 88 8 a a DT cord-273505-pcsw3vmx 88 9 dysfunctional dysfunctional JJ cord-273505-pcsw3vmx 88 10 immune immune JJ cord-273505-pcsw3vmx 88 11 response response NN cord-273505-pcsw3vmx 88 12 may may MD cord-273505-pcsw3vmx 88 13 cause cause VB cord-273505-pcsw3vmx 88 14 immunopathology immunopathology NN cord-273505-pcsw3vmx 88 15 in in IN cord-273505-pcsw3vmx 88 16 severe severe JJ cord-273505-pcsw3vmx 88 17 viral viral JJ cord-273505-pcsw3vmx 88 18 pneumonia pneumonia NN cord-273505-pcsw3vmx 88 19 , , , cord-273505-pcsw3vmx 88 20 resulting result VBG cord-273505-pcsw3vmx 88 21 in in IN cord-273505-pcsw3vmx 88 22 the the DT cord-273505-pcsw3vmx 88 23 current current JJ cord-273505-pcsw3vmx 88 24 understanding understanding NN cord-273505-pcsw3vmx 88 25 of of IN cord-273505-pcsw3vmx 88 26 IVIg ivig JJ cord-273505-pcsw3vmx 88 27 therapy therapy NN cord-273505-pcsw3vmx 88 28 in in IN cord-273505-pcsw3vmx 88 29 modulating modulate VBG cord-273505-pcsw3vmx 88 30 the the DT cord-273505-pcsw3vmx 88 31 hyperinflammatory hyperinflammatory JJ cord-273505-pcsw3vmx 88 32 conditions condition NNS cord-273505-pcsw3vmx 88 33 . . . cord-273505-pcsw3vmx 89 1 The the DT cord-273505-pcsw3vmx 89 2 cytokine cytokine NN cord-273505-pcsw3vmx 89 3 storm storm NN cord-273505-pcsw3vmx 89 4 syndrome syndrome NN cord-273505-pcsw3vmx 89 5 is be VBZ cord-273505-pcsw3vmx 89 6 a a DT cord-273505-pcsw3vmx 89 7 form form NN cord-273505-pcsw3vmx 89 8 of of IN cord-273505-pcsw3vmx 89 9 systemic systemic JJ cord-273505-pcsw3vmx 89 10 inflammatory inflammatory JJ cord-273505-pcsw3vmx 89 11 response response NN cord-273505-pcsw3vmx 89 12 common common JJ cord-273505-pcsw3vmx 89 13 to to IN cord-273505-pcsw3vmx 89 14 severe severe JJ cord-273505-pcsw3vmx 89 15 acute acute JJ cord-273505-pcsw3vmx 89 16 viral viral JJ cord-273505-pcsw3vmx 89 17 pneumonias pneumonia NNS cord-273505-pcsw3vmx 89 18 , , , cord-273505-pcsw3vmx 89 19 and and CC cord-273505-pcsw3vmx 89 20 its -PRON- PRP$ cord-273505-pcsw3vmx 89 21 presence presence NN cord-273505-pcsw3vmx 89 22 has have VBZ cord-273505-pcsw3vmx 89 23 also also RB cord-273505-pcsw3vmx 89 24 been be VBN cord-273505-pcsw3vmx 89 25 suggested suggest VBN cord-273505-pcsw3vmx 89 26 in in IN cord-273505-pcsw3vmx 89 27 severe severe JJ cord-273505-pcsw3vmx 89 28 cases case NNS cord-273505-pcsw3vmx 89 29 of of IN cord-273505-pcsw3vmx 89 30 COVID-19 covid-19 NN cord-273505-pcsw3vmx 89 31 . . . cord-273505-pcsw3vmx 90 1 There there EX cord-273505-pcsw3vmx 90 2 is be VBZ cord-273505-pcsw3vmx 90 3 a a DT cord-273505-pcsw3vmx 90 4 correlation correlation NN cord-273505-pcsw3vmx 90 5 between between IN cord-273505-pcsw3vmx 90 6 severity severity NN cord-273505-pcsw3vmx 90 7 of of IN cord-273505-pcsw3vmx 90 8 the the DT cord-273505-pcsw3vmx 90 9 cytokine cytokine NN cord-273505-pcsw3vmx 90 10 storm storm NN cord-273505-pcsw3vmx 90 11 and and CC cord-273505-pcsw3vmx 90 12 prognosis prognosis NN cord-273505-pcsw3vmx 90 13 of of IN cord-273505-pcsw3vmx 90 14 severe severe JJ cord-273505-pcsw3vmx 90 15 illnesses illness NNS cord-273505-pcsw3vmx 90 16 ( ( -LRB- cord-273505-pcsw3vmx 90 17 13 13 CD cord-273505-pcsw3vmx 90 18 ) ) -RRB- cord-273505-pcsw3vmx 90 19 . . . cord-273505-pcsw3vmx 91 1 At at IN cord-273505-pcsw3vmx 91 2 the the DT cord-273505-pcsw3vmx 91 3 initiation initiation NN cord-273505-pcsw3vmx 91 4 of of IN cord-273505-pcsw3vmx 91 5 infection infection NN cord-273505-pcsw3vmx 91 6 , , , cord-273505-pcsw3vmx 91 7 the the DT cord-273505-pcsw3vmx 91 8 host host NN cord-273505-pcsw3vmx 91 9 cells cell NNS cord-273505-pcsw3vmx 91 10 detect detect VBP cord-273505-pcsw3vmx 91 11 viruses virus NNS cord-273505-pcsw3vmx 91 12 through through IN cord-273505-pcsw3vmx 91 13 pattern pattern NN cord-273505-pcsw3vmx 91 14 recognition recognition NN cord-273505-pcsw3vmx 91 15 receptors receptor NNS cord-273505-pcsw3vmx 91 16 ( ( -LRB- cord-273505-pcsw3vmx 91 17 PRRs PRRs NNP cord-273505-pcsw3vmx 91 18 ) ) -RRB- cord-273505-pcsw3vmx 91 19 , , , cord-273505-pcsw3vmx 91 20 which which WDT cord-273505-pcsw3vmx 91 21 in in IN cord-273505-pcsw3vmx 91 22 turn turn NN cord-273505-pcsw3vmx 91 23 triggers trigger VBZ cord-273505-pcsw3vmx 91 24 an an DT cord-273505-pcsw3vmx 91 25 interferon interferon NN cord-273505-pcsw3vmx 91 26 ( ( -LRB- cord-273505-pcsw3vmx 91 27 IFN IFN NNP cord-273505-pcsw3vmx 91 28 ) ) -RRB- cord-273505-pcsw3vmx 91 29 response response NN cord-273505-pcsw3vmx 91 30 and and CC cord-273505-pcsw3vmx 91 31 produces produce VBZ cord-273505-pcsw3vmx 91 32 other other JJ cord-273505-pcsw3vmx 91 33 pro pro JJ cord-273505-pcsw3vmx 91 34 - - JJ cord-273505-pcsw3vmx 91 35 inflammatory inflammatory JJ cord-273505-pcsw3vmx 91 36 mediators mediator NNS cord-273505-pcsw3vmx 91 37 such such JJ cord-273505-pcsw3vmx 91 38 as as IN cord-273505-pcsw3vmx 91 39 cytokines cytokine NNS cord-273505-pcsw3vmx 91 40 and and CC cord-273505-pcsw3vmx 91 41 chemokines chemokine NNS cord-273505-pcsw3vmx 91 42 , , , cord-273505-pcsw3vmx 91 43 informing inform VBG cord-273505-pcsw3vmx 91 44 both both DT cord-273505-pcsw3vmx 91 45 innate innate JJ cord-273505-pcsw3vmx 91 46 and and CC cord-273505-pcsw3vmx 91 47 adaptive adaptive JJ cord-273505-pcsw3vmx 91 48 immune immune JJ cord-273505-pcsw3vmx 91 49 system system NN cord-273505-pcsw3vmx 91 50 to to TO cord-273505-pcsw3vmx 91 51 respond respond VB cord-273505-pcsw3vmx 91 52 appropriately appropriately RB cord-273505-pcsw3vmx 91 53 to to IN cord-273505-pcsw3vmx 91 54 infectious infectious JJ cord-273505-pcsw3vmx 91 55 pathogens pathogen NNS cord-273505-pcsw3vmx 91 56 . . . cord-273505-pcsw3vmx 92 1 A a DT cord-273505-pcsw3vmx 92 2 physiological physiological JJ cord-273505-pcsw3vmx 92 3 cytokine cytokine NN cord-273505-pcsw3vmx 92 4 and and CC cord-273505-pcsw3vmx 92 5 chemokine chemokine NN cord-273505-pcsw3vmx 92 6 response response NN cord-273505-pcsw3vmx 92 7 induced induce VBN cord-273505-pcsw3vmx 92 8 by by IN cord-273505-pcsw3vmx 92 9 viruses virus NNS cord-273505-pcsw3vmx 92 10 is be VBZ cord-273505-pcsw3vmx 92 11 a a DT cord-273505-pcsw3vmx 92 12 sprawling sprawl VBG cord-273505-pcsw3vmx 92 13 network network NN cord-273505-pcsw3vmx 92 14 , , , cord-273505-pcsw3vmx 92 15 which which WDT cord-273505-pcsw3vmx 92 16 involves involve VBZ cord-273505-pcsw3vmx 92 17 endothelial endothelial JJ cord-273505-pcsw3vmx 92 18 cells cell NNS cord-273505-pcsw3vmx 92 19 , , , cord-273505-pcsw3vmx 92 20 mononuclear mononuclear JJ cord-273505-pcsw3vmx 92 21 macrophages macrophage NNS cord-273505-pcsw3vmx 92 22 , , , cord-273505-pcsw3vmx 92 23 dendritic dendritic JJ cord-273505-pcsw3vmx 92 24 cells cell NNS cord-273505-pcsw3vmx 92 25 , , , cord-273505-pcsw3vmx 92 26 natural natural JJ cord-273505-pcsw3vmx 92 27 killer killer NN cord-273505-pcsw3vmx 92 28 cells cell NNS cord-273505-pcsw3vmx 92 29 , , , cord-273505-pcsw3vmx 92 30 and and CC cord-273505-pcsw3vmx 92 31 lymphocytes lymphocyte NNS cord-273505-pcsw3vmx 92 32 , , , cord-273505-pcsw3vmx 92 33 contributing contribute VBG cord-273505-pcsw3vmx 92 34 to to IN cord-273505-pcsw3vmx 92 35 pathogen pathogen NN cord-273505-pcsw3vmx 92 36 clearance clearance NN cord-273505-pcsw3vmx 92 37 and and CC cord-273505-pcsw3vmx 92 38 immune immune JJ cord-273505-pcsw3vmx 92 39 protection protection NN cord-273505-pcsw3vmx 92 40 . . . cord-273505-pcsw3vmx 93 1 However however RB cord-273505-pcsw3vmx 93 2 , , , cord-273505-pcsw3vmx 93 3 an an DT cord-273505-pcsw3vmx 93 4 uncontrolled uncontrolled JJ cord-273505-pcsw3vmx 93 5 positive positive JJ cord-273505-pcsw3vmx 93 6 feedback feedback NN cord-273505-pcsw3vmx 93 7 involving involve VBG cord-273505-pcsw3vmx 93 8 all all PDT cord-273505-pcsw3vmx 93 9 the the DT cord-273505-pcsw3vmx 93 10 relevant relevant JJ cord-273505-pcsw3vmx 93 11 players player NNS cord-273505-pcsw3vmx 93 12 leads lead VBZ cord-273505-pcsw3vmx 93 13 to to IN cord-273505-pcsw3vmx 93 14 pathogenic pathogenic JJ cord-273505-pcsw3vmx 93 15 hyperinflammation hyperinflammation NN cord-273505-pcsw3vmx 93 16 and and CC cord-273505-pcsw3vmx 93 17 can can MD cord-273505-pcsw3vmx 93 18 cause cause VB cord-273505-pcsw3vmx 93 19 extensive extensive JJ cord-273505-pcsw3vmx 93 20 damage damage NN cord-273505-pcsw3vmx 93 21 to to IN cord-273505-pcsw3vmx 93 22 tissues tissue NNS cord-273505-pcsw3vmx 93 23 . . . cord-273505-pcsw3vmx 94 1 Endothelial endothelial JJ cord-273505-pcsw3vmx 94 2 cells cell NNS cord-273505-pcsw3vmx 94 3 can can MD cord-273505-pcsw3vmx 94 4 secrete secrete VB cord-273505-pcsw3vmx 94 5 inflammatory inflammatory JJ cord-273505-pcsw3vmx 94 6 mediators mediator NNS cord-273505-pcsw3vmx 94 7 , , , cord-273505-pcsw3vmx 94 8 including include VBG cord-273505-pcsw3vmx 94 9 cytokines cytokine NNS cord-273505-pcsw3vmx 94 10 , , , cord-273505-pcsw3vmx 94 11 chemokines chemokine NNS cord-273505-pcsw3vmx 94 12 , , , cord-273505-pcsw3vmx 94 13 histamine histamine NN cord-273505-pcsw3vmx 94 14 , , , cord-273505-pcsw3vmx 94 15 matrix matrix NN cord-273505-pcsw3vmx 94 16 metalloproteinases metalloproteinase NNS cord-273505-pcsw3vmx 94 17 , , , cord-273505-pcsw3vmx 94 18 and and CC cord-273505-pcsw3vmx 94 19 adhesion adhesion NN cord-273505-pcsw3vmx 94 20 molecules molecule NNS cord-273505-pcsw3vmx 94 21 , , , cord-273505-pcsw3vmx 94 22 which which WDT cord-273505-pcsw3vmx 94 23 can can MD cord-273505-pcsw3vmx 94 24 lead lead VB cord-273505-pcsw3vmx 94 25 to to IN cord-273505-pcsw3vmx 94 26 inflammatory inflammatory JJ cord-273505-pcsw3vmx 94 27 cell cell NN cord-273505-pcsw3vmx 94 28 infiltration infiltration NN cord-273505-pcsw3vmx 94 29 and and CC cord-273505-pcsw3vmx 94 30 tissue tissue NN cord-273505-pcsw3vmx 94 31 damage damage NN cord-273505-pcsw3vmx 94 32 , , , cord-273505-pcsw3vmx 94 33 and and CC cord-273505-pcsw3vmx 94 34 plays play VBZ cord-273505-pcsw3vmx 94 35 an an DT cord-273505-pcsw3vmx 94 36 essential essential JJ cord-273505-pcsw3vmx 94 37 role role NN cord-273505-pcsw3vmx 94 38 in in IN cord-273505-pcsw3vmx 94 39 inflammation inflammation NN cord-273505-pcsw3vmx 94 40 , , , cord-273505-pcsw3vmx 94 41 hemostasis hemostasis NN cord-273505-pcsw3vmx 94 42 , , , cord-273505-pcsw3vmx 94 43 and and CC cord-273505-pcsw3vmx 94 44 angiogenesis angiogenesis NN cord-273505-pcsw3vmx 94 45 . . . cord-273505-pcsw3vmx 95 1 SARS SARS NNP cord-273505-pcsw3vmx 95 2 - - HYPH cord-273505-pcsw3vmx 95 3 CoV-2 CoV-2 NNP cord-273505-pcsw3vmx 95 4 infects infect VBZ cord-273505-pcsw3vmx 95 5 host host NN cord-273505-pcsw3vmx 95 6 cells cell NNS cord-273505-pcsw3vmx 95 7 using use VBG cord-273505-pcsw3vmx 95 8 the the DT cord-273505-pcsw3vmx 95 9 ACE2 ACE2 NNP cord-273505-pcsw3vmx 95 10 receptor receptor NN cord-273505-pcsw3vmx 95 11 , , , cord-273505-pcsw3vmx 95 12 which which WDT cord-273505-pcsw3vmx 95 13 is be VBZ cord-273505-pcsw3vmx 95 14 widely widely RB cord-273505-pcsw3vmx 95 15 expressed express VBN cord-273505-pcsw3vmx 95 16 on on IN cord-273505-pcsw3vmx 95 17 endothelial endothelial JJ cord-273505-pcsw3vmx 95 18 cells cell NNS cord-273505-pcsw3vmx 95 19 . . . cord-273505-pcsw3vmx 96 1 Endothelial endothelial JJ cord-273505-pcsw3vmx 96 2 cell cell NN cord-273505-pcsw3vmx 96 3 infection infection NN cord-273505-pcsw3vmx 96 4 and and CC cord-273505-pcsw3vmx 96 5 endotheliosis endotheliosis NN cord-273505-pcsw3vmx 96 6 have have VBP cord-273505-pcsw3vmx 96 7 been be VBN cord-273505-pcsw3vmx 96 8 observed observe VBN cord-273505-pcsw3vmx 96 9 in in IN cord-273505-pcsw3vmx 96 10 some some DT cord-273505-pcsw3vmx 96 11 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 96 12 patients patient NNS cord-273505-pcsw3vmx 96 13 ( ( -LRB- cord-273505-pcsw3vmx 96 14 79 79 CD cord-273505-pcsw3vmx 96 15 ) ) -RRB- cord-273505-pcsw3vmx 96 16 . . . cord-273505-pcsw3vmx 97 1 Direct direct JJ cord-273505-pcsw3vmx 97 2 viral viral JJ cord-273505-pcsw3vmx 97 3 infection infection NN cord-273505-pcsw3vmx 97 4 of of IN cord-273505-pcsw3vmx 97 5 the the DT cord-273505-pcsw3vmx 97 6 endothelium endothelium NN cord-273505-pcsw3vmx 97 7 may may MD cord-273505-pcsw3vmx 97 8 result result VB cord-273505-pcsw3vmx 97 9 in in IN cord-273505-pcsw3vmx 97 10 extensive extensive JJ cord-273505-pcsw3vmx 97 11 endothelial endothelial JJ cord-273505-pcsw3vmx 97 12 dysfunction dysfunction NN cord-273505-pcsw3vmx 97 13 and and CC cord-273505-pcsw3vmx 97 14 disseminated disseminate VBN cord-273505-pcsw3vmx 97 15 intravascular intravascular JJ cord-273505-pcsw3vmx 97 16 coagulation coagulation NN cord-273505-pcsw3vmx 97 17 ( ( -LRB- cord-273505-pcsw3vmx 97 18 17 17 CD cord-273505-pcsw3vmx 97 19 , , , cord-273505-pcsw3vmx 97 20 79 79 CD cord-273505-pcsw3vmx 97 21 ) ) -RRB- cord-273505-pcsw3vmx 97 22 . . . cord-273505-pcsw3vmx 98 1 In in IN cord-273505-pcsw3vmx 98 2 addition addition NN cord-273505-pcsw3vmx 98 3 , , , cord-273505-pcsw3vmx 98 4 abnormal abnormal JJ cord-273505-pcsw3vmx 98 5 levels level NNS cord-273505-pcsw3vmx 98 6 of of IN cord-273505-pcsw3vmx 98 7 complement complement JJ cord-273505-pcsw3vmx 98 8 factors factor NNS cord-273505-pcsw3vmx 98 9 and and CC cord-273505-pcsw3vmx 98 10 the the DT cord-273505-pcsw3vmx 98 11 deposition deposition NN cord-273505-pcsw3vmx 98 12 of of IN cord-273505-pcsw3vmx 98 13 terminal terminal JJ cord-273505-pcsw3vmx 98 14 complement complement NN cord-273505-pcsw3vmx 98 15 complex complex NN cord-273505-pcsw3vmx 98 16 also also RB cord-273505-pcsw3vmx 98 17 suggested suggest VBD cord-273505-pcsw3vmx 98 18 that that IN cord-273505-pcsw3vmx 98 19 the the DT cord-273505-pcsw3vmx 98 20 activation activation NN cord-273505-pcsw3vmx 98 21 of of IN cord-273505-pcsw3vmx 98 22 complement complement JJ cord-273505-pcsw3vmx 98 23 pathways pathway NNS cord-273505-pcsw3vmx 98 24 may may MD cord-273505-pcsw3vmx 98 25 contribute contribute VB cord-273505-pcsw3vmx 98 26 to to IN cord-273505-pcsw3vmx 98 27 endothelial endothelial JJ cord-273505-pcsw3vmx 98 28 damage damage NN cord-273505-pcsw3vmx 98 29 and and CC cord-273505-pcsw3vmx 98 30 the the DT cord-273505-pcsw3vmx 98 31 associated associate VBN cord-273505-pcsw3vmx 98 32 pro pro JJ cord-273505-pcsw3vmx 98 33 - - JJ cord-273505-pcsw3vmx 98 34 coagulant coagulant JJ cord-273505-pcsw3vmx 98 35 state state NN cord-273505-pcsw3vmx 98 36 in in IN cord-273505-pcsw3vmx 98 37 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 98 38 ( ( -LRB- cord-273505-pcsw3vmx 98 39 80 80 CD cord-273505-pcsw3vmx 98 40 , , , cord-273505-pcsw3vmx 98 41 81 81 CD cord-273505-pcsw3vmx 98 42 ) ) -RRB- cord-273505-pcsw3vmx 98 43 . . . cord-273505-pcsw3vmx 99 1 Although although IN cord-273505-pcsw3vmx 99 2 vasculitis vasculitis NN cord-273505-pcsw3vmx 99 3 and and CC cord-273505-pcsw3vmx 99 4 autoantibodies autoantibody NNS cord-273505-pcsw3vmx 99 5 against against IN cord-273505-pcsw3vmx 99 6 endothelial endothelial JJ cord-273505-pcsw3vmx 99 7 cells cell NNS cord-273505-pcsw3vmx 99 8 have have VBP cord-273505-pcsw3vmx 99 9 been be VBN cord-273505-pcsw3vmx 99 10 reported report VBN cord-273505-pcsw3vmx 99 11 and and CC cord-273505-pcsw3vmx 99 12 detected detect VBN cord-273505-pcsw3vmx 99 13 in in IN cord-273505-pcsw3vmx 99 14 SARS SARS NNP cord-273505-pcsw3vmx 99 15 patients patient NNS cord-273505-pcsw3vmx 99 16 , , , cord-273505-pcsw3vmx 99 17 direct direct JJ cord-273505-pcsw3vmx 99 18 endothelial endothelial JJ cord-273505-pcsw3vmx 99 19 cell cell NN cord-273505-pcsw3vmx 99 20 infection infection NN cord-273505-pcsw3vmx 99 21 has have VBZ cord-273505-pcsw3vmx 99 22 n't not RB cord-273505-pcsw3vmx 99 23 been be VBN cord-273505-pcsw3vmx 99 24 demonstrated demonstrate VBN cord-273505-pcsw3vmx 99 25 yet yet RB cord-273505-pcsw3vmx 100 1 ( ( -LRB- cord-273505-pcsw3vmx 100 2 82 82 CD cord-273505-pcsw3vmx 100 3 ) ) -RRB- cord-273505-pcsw3vmx 101 1 ( ( -LRB- cord-273505-pcsw3vmx 101 2 83 83 CD cord-273505-pcsw3vmx 101 3 ) ) -RRB- cord-273505-pcsw3vmx 102 1 ( ( -LRB- cord-273505-pcsw3vmx 102 2 84 84 CD cord-273505-pcsw3vmx 102 3 ) ) -RRB- cord-273505-pcsw3vmx 102 4 . . . cord-273505-pcsw3vmx 103 1 These these DT cord-273505-pcsw3vmx 103 2 differences difference NNS cord-273505-pcsw3vmx 103 3 in in IN cord-273505-pcsw3vmx 103 4 endothelial endothelial JJ cord-273505-pcsw3vmx 103 5 infections infection NNS cord-273505-pcsw3vmx 103 6 may may MD cord-273505-pcsw3vmx 103 7 contribute contribute VB cord-273505-pcsw3vmx 103 8 to to IN cord-273505-pcsw3vmx 103 9 the the DT cord-273505-pcsw3vmx 103 10 different different JJ cord-273505-pcsw3vmx 103 11 immunopathology immunopathology NN cord-273505-pcsw3vmx 103 12 between between IN cord-273505-pcsw3vmx 103 13 SARS SARS NNP cord-273505-pcsw3vmx 103 14 - - HYPH cord-273505-pcsw3vmx 103 15 CoV-1 CoV-1 NNP cord-273505-pcsw3vmx 103 16 and and CC cord-273505-pcsw3vmx 103 17 SARS SARS NNP cord-273505-pcsw3vmx 103 18 - - HYPH cord-273505-pcsw3vmx 103 19 CoV-2 CoV-2 NNP cord-273505-pcsw3vmx 103 20 . . . cord-273505-pcsw3vmx 104 1 In in IN cord-273505-pcsw3vmx 104 2 influenza influenza NN cord-273505-pcsw3vmx 104 3 , , , cord-273505-pcsw3vmx 104 4 the the DT cord-273505-pcsw3vmx 104 5 central central JJ cord-273505-pcsw3vmx 104 6 role role NN cord-273505-pcsw3vmx 104 7 of of IN cord-273505-pcsw3vmx 104 8 the the DT cord-273505-pcsw3vmx 104 9 pulmonary pulmonary JJ cord-273505-pcsw3vmx 104 10 endothelium endothelium NN cord-273505-pcsw3vmx 104 11 for for IN cord-273505-pcsw3vmx 104 12 the the DT cord-273505-pcsw3vmx 104 13 regulation regulation NN cord-273505-pcsw3vmx 104 14 of of IN cord-273505-pcsw3vmx 104 15 innate innate JJ cord-273505-pcsw3vmx 104 16 immune immune JJ cord-273505-pcsw3vmx 104 17 cell cell NN cord-273505-pcsw3vmx 104 18 recruitment recruitment NN cord-273505-pcsw3vmx 104 19 into into IN cord-273505-pcsw3vmx 104 20 the the DT cord-273505-pcsw3vmx 104 21 lungs lung NNS cord-273505-pcsw3vmx 104 22 , , , cord-273505-pcsw3vmx 104 23 along along IN cord-273505-pcsw3vmx 104 24 with with IN cord-273505-pcsw3vmx 104 25 the the DT cord-273505-pcsw3vmx 104 26 production production NN cord-273505-pcsw3vmx 104 27 of of IN cord-273505-pcsw3vmx 104 28 excessive excessive JJ cord-273505-pcsw3vmx 104 29 pro pro JJ cord-273505-pcsw3vmx 104 30 - - JJ cord-273505-pcsw3vmx 104 31 inflammatory inflammatory JJ cord-273505-pcsw3vmx 104 32 cytokines cytokine NNS cord-273505-pcsw3vmx 104 33 and and CC cord-273505-pcsw3vmx 104 34 chemokines chemokine NNS cord-273505-pcsw3vmx 104 35 , , , cord-273505-pcsw3vmx 104 36 has have VBZ cord-273505-pcsw3vmx 104 37 been be VBN cord-273505-pcsw3vmx 104 38 demonstrated demonstrate VBN cord-273505-pcsw3vmx 104 39 ( ( -LRB- cord-273505-pcsw3vmx 104 40 85 85 CD cord-273505-pcsw3vmx 104 41 ) ) -RRB- cord-273505-pcsw3vmx 104 42 ( ( -LRB- cord-273505-pcsw3vmx 104 43 86 86 CD cord-273505-pcsw3vmx 104 44 ) ) -RRB- cord-273505-pcsw3vmx 104 45 ( ( -LRB- cord-273505-pcsw3vmx 104 46 87 87 CD cord-273505-pcsw3vmx 104 47 ) ) -RRB- cord-273505-pcsw3vmx 104 48 . . . cord-273505-pcsw3vmx 105 1 The the DT cord-273505-pcsw3vmx 105 2 anti anti JJ cord-273505-pcsw3vmx 105 3 - - JJ cord-273505-pcsw3vmx 105 4 inflammatory inflammatory JJ cord-273505-pcsw3vmx 105 5 effect effect NN cord-273505-pcsw3vmx 105 6 of of IN cord-273505-pcsw3vmx 105 7 high high JJ cord-273505-pcsw3vmx 105 8 - - HYPH cord-273505-pcsw3vmx 105 9 dose dose NN cord-273505-pcsw3vmx 105 10 IVIg ivig NN cord-273505-pcsw3vmx 105 11 on on IN cord-273505-pcsw3vmx 105 12 endothelial endothelial JJ cord-273505-pcsw3vmx 105 13 cells cell NNS cord-273505-pcsw3vmx 105 14 is be VBZ cord-273505-pcsw3vmx 105 15 mainly mainly RB cord-273505-pcsw3vmx 105 16 inferred infer VBN cord-273505-pcsw3vmx 105 17 from from IN cord-273505-pcsw3vmx 105 18 in in IN cord-273505-pcsw3vmx 105 19 vitro vitro FW cord-273505-pcsw3vmx 105 20 observations observation NNS cord-273505-pcsw3vmx 105 21 . . . cord-273505-pcsw3vmx 106 1 High high JJ cord-273505-pcsw3vmx 106 2 - - HYPH cord-273505-pcsw3vmx 106 3 dose dose NN cord-273505-pcsw3vmx 106 4 IgG igg NN cord-273505-pcsw3vmx 106 5 has have VBZ cord-273505-pcsw3vmx 106 6 been be VBN cord-273505-pcsw3vmx 106 7 shown show VBN cord-273505-pcsw3vmx 106 8 to to IN cord-273505-pcsw3vmx 106 9 specifically specifically RB cord-273505-pcsw3vmx 106 10 and and CC cord-273505-pcsw3vmx 106 11 completely completely RB cord-273505-pcsw3vmx 106 12 inhibit inhibit VB cord-273505-pcsw3vmx 106 13 TNF TNF NNP cord-273505-pcsw3vmx 106 14 - - HYPH cord-273505-pcsw3vmx 106 15 αinduced αinduce VBN cord-273505-pcsw3vmx 106 16 secretion secretion NN cord-273505-pcsw3vmx 106 17 of of IN cord-273505-pcsw3vmx 106 18 pro pro JJ cord-273505-pcsw3vmx 106 19 - - JJ cord-273505-pcsw3vmx 106 20 inflammatory inflammatory JJ cord-273505-pcsw3vmx 106 21 cytokines cytokine NNS cord-273505-pcsw3vmx 106 22 ( ( -LRB- cord-273505-pcsw3vmx 106 23 e.g. e.g. RB cord-273505-pcsw3vmx 106 24 , , , cord-273505-pcsw3vmx 106 25 IL-6 IL-6 NNP cord-273505-pcsw3vmx 106 26 , , , cord-273505-pcsw3vmx 106 27 G G NNP cord-273505-pcsw3vmx 106 28 - - HYPH cord-273505-pcsw3vmx 106 29 CSF CSF NNP cord-273505-pcsw3vmx 106 30 , , , cord-273505-pcsw3vmx 106 31 and and CC cord-273505-pcsw3vmx 106 32 IL-1β IL-1β NNP cord-273505-pcsw3vmx 106 33 ) ) -RRB- cord-273505-pcsw3vmx 106 34 and and CC cord-273505-pcsw3vmx 106 35 production production NN cord-273505-pcsw3vmx 106 36 of of IN cord-273505-pcsw3vmx 106 37 E e NN cord-273505-pcsw3vmx 106 38 - - NN cord-273505-pcsw3vmx 106 39 selectin selectin NNP cord-273505-pcsw3vmx 106 40 in in IN cord-273505-pcsw3vmx 106 41 cultured cultured JJ cord-273505-pcsw3vmx 106 42 human human JJ cord-273505-pcsw3vmx 106 43 coronary coronary JJ cord-273505-pcsw3vmx 106 44 artery artery NN cord-273505-pcsw3vmx 106 45 endothelial endothelial JJ cord-273505-pcsw3vmx 106 46 cells cell NNS cord-273505-pcsw3vmx 106 47 ( ( -LRB- cord-273505-pcsw3vmx 106 48 88 88 CD cord-273505-pcsw3vmx 106 49 , , , cord-273505-pcsw3vmx 106 50 89 89 CD cord-273505-pcsw3vmx 106 51 ) ) -RRB- cord-273505-pcsw3vmx 106 52 . . . cord-273505-pcsw3vmx 107 1 These these DT cord-273505-pcsw3vmx 107 2 effects effect NNS cord-273505-pcsw3vmx 107 3 may may MD cord-273505-pcsw3vmx 107 4 predominantly predominantly RB cord-273505-pcsw3vmx 107 5 be be VB cord-273505-pcsw3vmx 107 6 mediated mediate VBN cord-273505-pcsw3vmx 107 7 by by IN cord-273505-pcsw3vmx 107 8 F(ab f(ab NN cord-273505-pcsw3vmx 107 9 ) ) -RRB- cord-273505-pcsw3vmx 107 10 ′ ′ CD cord-273505-pcsw3vmx 107 11 2 2 CD cord-273505-pcsw3vmx 107 12 -mediated -mediated JJ cord-273505-pcsw3vmx 107 13 mechanisms mechanism NNS cord-273505-pcsw3vmx 107 14 ( ( -LRB- cord-273505-pcsw3vmx 107 15 88 88 CD cord-273505-pcsw3vmx 107 16 , , , cord-273505-pcsw3vmx 107 17 89 89 CD cord-273505-pcsw3vmx 107 18 ) ) -RRB- cord-273505-pcsw3vmx 107 19 . . . cord-273505-pcsw3vmx 108 1 The the DT cord-273505-pcsw3vmx 108 2 expression expression NN cord-273505-pcsw3vmx 108 3 of of IN cord-273505-pcsw3vmx 108 4 endothelial endothelial JJ cord-273505-pcsw3vmx 108 5 adhesion adhesion NN cord-273505-pcsw3vmx 108 6 molecules molecule NNS cord-273505-pcsw3vmx 108 7 is be VBZ cord-273505-pcsw3vmx 108 8 also also RB cord-273505-pcsw3vmx 108 9 reduced reduce VBN cord-273505-pcsw3vmx 108 10 by by IN cord-273505-pcsw3vmx 108 11 co co NN cord-273505-pcsw3vmx 108 12 - - JJ cord-273505-pcsw3vmx 108 13 culturing culture VBG cord-273505-pcsw3vmx 108 14 endothelial endothelial JJ cord-273505-pcsw3vmx 108 15 cells cell NNS cord-273505-pcsw3vmx 108 16 with with IN cord-273505-pcsw3vmx 108 17 an an DT cord-273505-pcsw3vmx 108 18 IVIg ivig JJ cord-273505-pcsw3vmx 108 19 preparation preparation NN cord-273505-pcsw3vmx 108 20 ( ( -LRB- cord-273505-pcsw3vmx 108 21 90 90 CD cord-273505-pcsw3vmx 108 22 ) ) -RRB- cord-273505-pcsw3vmx 108 23 . . . cord-273505-pcsw3vmx 109 1 Additionally additionally RB cord-273505-pcsw3vmx 109 2 , , , cord-273505-pcsw3vmx 109 3 the the DT cord-273505-pcsw3vmx 109 4 inhibitory inhibitory JJ cord-273505-pcsw3vmx 109 5 effects effect NNS cord-273505-pcsw3vmx 109 6 of of IN cord-273505-pcsw3vmx 109 7 the the DT cord-273505-pcsw3vmx 109 8 classical classical JJ cord-273505-pcsw3vmx 109 9 complement complement NN cord-273505-pcsw3vmx 109 10 pathway pathway NN cord-273505-pcsw3vmx 109 11 by by IN cord-273505-pcsw3vmx 109 12 high high JJ cord-273505-pcsw3vmx 109 13 - - HYPH cord-273505-pcsw3vmx 109 14 dose dose NN cord-273505-pcsw3vmx 109 15 IVIg ivig NN cord-273505-pcsw3vmx 109 16 may may MD cord-273505-pcsw3vmx 109 17 offer offer VB cord-273505-pcsw3vmx 109 18 a a DT cord-273505-pcsw3vmx 109 19 potential potential JJ cord-273505-pcsw3vmx 109 20 protective protective JJ cord-273505-pcsw3vmx 109 21 effect effect NN cord-273505-pcsw3vmx 109 22 on on IN cord-273505-pcsw3vmx 109 23 virus virus NN cord-273505-pcsw3vmx 109 24 - - HYPH cord-273505-pcsw3vmx 109 25 induced induce VBN cord-273505-pcsw3vmx 109 26 endothelial endothelial JJ cord-273505-pcsw3vmx 109 27 damage damage NN cord-273505-pcsw3vmx 109 28 . . . cord-273505-pcsw3vmx 110 1 Dendritic dendritic JJ cord-273505-pcsw3vmx 110 2 cells cell NNS cord-273505-pcsw3vmx 110 3 ( ( -LRB- cord-273505-pcsw3vmx 110 4 DCs DCs NNP cord-273505-pcsw3vmx 110 5 ) ) -RRB- cord-273505-pcsw3vmx 110 6 are be VBP cord-273505-pcsw3vmx 110 7 antigen antigen NN cord-273505-pcsw3vmx 110 8 - - HYPH cord-273505-pcsw3vmx 110 9 presenting present VBG cord-273505-pcsw3vmx 110 10 cells cell NNS cord-273505-pcsw3vmx 110 11 of of IN cord-273505-pcsw3vmx 110 12 the the DT cord-273505-pcsw3vmx 110 13 innate innate JJ cord-273505-pcsw3vmx 110 14 immune immune JJ cord-273505-pcsw3vmx 110 15 system system NN cord-273505-pcsw3vmx 110 16 . . . cord-273505-pcsw3vmx 111 1 Plasmacytoid Plasmacytoid NNP cord-273505-pcsw3vmx 111 2 dendritic dendritic JJ cord-273505-pcsw3vmx 111 3 cells cell NNS cord-273505-pcsw3vmx 111 4 ( ( -LRB- cord-273505-pcsw3vmx 111 5 pDCs pDCs NNP cord-273505-pcsw3vmx 111 6 ) ) -RRB- cord-273505-pcsw3vmx 111 7 are be VBP cord-273505-pcsw3vmx 111 8 unique unique JJ cord-273505-pcsw3vmx 111 9 sentinel sentinel JJ cord-273505-pcsw3vmx 111 10 cells cell NNS cord-273505-pcsw3vmx 111 11 that that WDT cord-273505-pcsw3vmx 111 12 can can MD cord-273505-pcsw3vmx 111 13 recognize recognize VB cord-273505-pcsw3vmx 111 14 a a DT cord-273505-pcsw3vmx 111 15 virus virus NN cord-273505-pcsw3vmx 111 16 through through IN cord-273505-pcsw3vmx 111 17 PRRs prr NNS cord-273505-pcsw3vmx 111 18 , , , cord-273505-pcsw3vmx 111 19 and and CC cord-273505-pcsw3vmx 111 20 enhance enhance VB cord-273505-pcsw3vmx 111 21 the the DT cord-273505-pcsw3vmx 111 22 secretion secretion NN cord-273505-pcsw3vmx 111 23 of of IN cord-273505-pcsw3vmx 111 24 IFN IFN NNP cord-273505-pcsw3vmx 111 25 ( ( -LRB- cord-273505-pcsw3vmx 111 26 91 91 CD cord-273505-pcsw3vmx 111 27 , , , cord-273505-pcsw3vmx 111 28 92 92 CD cord-273505-pcsw3vmx 111 29 ) ) -RRB- cord-273505-pcsw3vmx 111 30 . . . cord-273505-pcsw3vmx 112 1 Data datum NNS cord-273505-pcsw3vmx 112 2 from from IN cord-273505-pcsw3vmx 112 3 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 112 4 patients patient NNS cord-273505-pcsw3vmx 112 5 and and CC cord-273505-pcsw3vmx 112 6 a a DT cord-273505-pcsw3vmx 112 7 ferret ferret JJ cord-273505-pcsw3vmx 112 8 model model NN cord-273505-pcsw3vmx 112 9 reveal reveal VB cord-273505-pcsw3vmx 112 10 low low JJ cord-273505-pcsw3vmx 112 11 levels level NNS cord-273505-pcsw3vmx 112 12 of of IN cord-273505-pcsw3vmx 112 13 IFN IFN NNP cord-273505-pcsw3vmx 112 14 with with IN cord-273505-pcsw3vmx 112 15 contrastingly contrastingly RB cord-273505-pcsw3vmx 112 16 high high JJ cord-273505-pcsw3vmx 112 17 levels level NNS cord-273505-pcsw3vmx 112 18 of of IN cord-273505-pcsw3vmx 112 19 IL-6 IL-6 NNP cord-273505-pcsw3vmx 112 20 and and CC cord-273505-pcsw3vmx 112 21 a a DT cord-273505-pcsw3vmx 112 22 strong strong JJ cord-273505-pcsw3vmx 112 23 chemokine chemokine NN cord-273505-pcsw3vmx 112 24 response response NN cord-273505-pcsw3vmx 112 25 , , , cord-273505-pcsw3vmx 112 26 suggesting suggest VBG cord-273505-pcsw3vmx 112 27 a a DT cord-273505-pcsw3vmx 112 28 similar similar JJ cord-273505-pcsw3vmx 112 29 hyper hyper JJ cord-273505-pcsw3vmx 112 30 - - JJ cord-273505-pcsw3vmx 112 31 inflammatory inflammatory JJ cord-273505-pcsw3vmx 112 32 response response NN cord-273505-pcsw3vmx 112 33 pattern pattern NN cord-273505-pcsw3vmx 112 34 to to IN cord-273505-pcsw3vmx 112 35 SARS SARS NNP cord-273505-pcsw3vmx 112 36 and and CC cord-273505-pcsw3vmx 112 37 MERS MERS NNP cord-273505-pcsw3vmx 112 38 ( ( -LRB- cord-273505-pcsw3vmx 112 39 93 93 CD cord-273505-pcsw3vmx 112 40 ) ) -RRB- cord-273505-pcsw3vmx 112 41 . . . cord-273505-pcsw3vmx 113 1 Several several JJ cord-273505-pcsw3vmx 113 2 SARS SARS NNP cord-273505-pcsw3vmx 113 3 - - HYPH cord-273505-pcsw3vmx 113 4 CoV CoV NNP cord-273505-pcsw3vmx 113 5 and and CC cord-273505-pcsw3vmx 113 6 MERS MERS NNP cord-273505-pcsw3vmx 113 7 - - HYPH cord-273505-pcsw3vmx 113 8 CoV cov NN cord-273505-pcsw3vmx 113 9 proteins protein NNS cord-273505-pcsw3vmx 113 10 have have VBP cord-273505-pcsw3vmx 113 11 been be VBN cord-273505-pcsw3vmx 113 12 shown show VBN cord-273505-pcsw3vmx 113 13 to to TO cord-273505-pcsw3vmx 113 14 antagonize antagonize VB cord-273505-pcsw3vmx 113 15 the the DT cord-273505-pcsw3vmx 113 16 IFN IFN NNP cord-273505-pcsw3vmx 113 17 response response NN cord-273505-pcsw3vmx 113 18 in in IN cord-273505-pcsw3vmx 113 19 order order NN cord-273505-pcsw3vmx 113 20 to to TO cord-273505-pcsw3vmx 113 21 reach reach VB cord-273505-pcsw3vmx 113 22 high high JJ cord-273505-pcsw3vmx 113 23 viral viral JJ cord-273505-pcsw3vmx 113 24 titers titer NNS cord-273505-pcsw3vmx 113 25 after after IN cord-273505-pcsw3vmx 113 26 early early JJ cord-273505-pcsw3vmx 113 27 infection infection NN cord-273505-pcsw3vmx 113 28 ( ( -LRB- cord-273505-pcsw3vmx 113 29 94 94 CD cord-273505-pcsw3vmx 113 30 ) ) -RRB- cord-273505-pcsw3vmx 113 31 ( ( -LRB- cord-273505-pcsw3vmx 113 32 95 95 CD cord-273505-pcsw3vmx 113 33 ) ) -RRB- cord-273505-pcsw3vmx 114 1 ( ( -LRB- cord-273505-pcsw3vmx 114 2 96 96 CD cord-273505-pcsw3vmx 114 3 ) ) -RRB- cord-273505-pcsw3vmx 114 4 ( ( -LRB- cord-273505-pcsw3vmx 114 5 97 97 CD cord-273505-pcsw3vmx 114 6 ) ) -RRB- cord-273505-pcsw3vmx 114 7 ( ( -LRB- cord-273505-pcsw3vmx 114 8 98 98 CD cord-273505-pcsw3vmx 114 9 ) ) -RRB- cord-273505-pcsw3vmx 114 10 . . . cord-273505-pcsw3vmx 115 1 Delayed delayed JJ cord-273505-pcsw3vmx 115 2 and and CC cord-273505-pcsw3vmx 115 3 massive massive JJ cord-273505-pcsw3vmx 115 4 IFN IFN NNP cord-273505-pcsw3vmx 115 5 signaling signaling NN cord-273505-pcsw3vmx 115 6 is be VBZ cord-273505-pcsw3vmx 115 7 suggested suggest VBN cord-273505-pcsw3vmx 115 8 to to TO cord-273505-pcsw3vmx 115 9 further further RB cord-273505-pcsw3vmx 115 10 orchestrate orchestrate VB cord-273505-pcsw3vmx 115 11 extensive extensive JJ cord-273505-pcsw3vmx 115 12 inflammatory inflammatory JJ cord-273505-pcsw3vmx 115 13 monocyte monocyte JJ cord-273505-pcsw3vmx 115 14 - - HYPH cord-273505-pcsw3vmx 115 15 macrophage macrophage NN cord-273505-pcsw3vmx 115 16 responses response NNS cord-273505-pcsw3vmx 115 17 and and CC cord-273505-pcsw3vmx 115 18 induce induce VB cord-273505-pcsw3vmx 115 19 T T NNP cord-273505-pcsw3vmx 115 20 cell cell NN cord-273505-pcsw3vmx 115 21 apoptosis apoptosis NN cord-273505-pcsw3vmx 115 22 , , , cord-273505-pcsw3vmx 115 23 resulting result VBG cord-273505-pcsw3vmx 115 24 in in IN cord-273505-pcsw3vmx 115 25 a a DT cord-273505-pcsw3vmx 115 26 dysfunctional dysfunctional JJ cord-273505-pcsw3vmx 115 27 immune immune JJ cord-273505-pcsw3vmx 115 28 response response NN cord-273505-pcsw3vmx 115 29 and and CC cord-273505-pcsw3vmx 115 30 cytokine cytokine NN cord-273505-pcsw3vmx 115 31 storm storm NN cord-273505-pcsw3vmx 115 32 during during IN cord-273505-pcsw3vmx 115 33 SARS SARS NNP cord-273505-pcsw3vmx 115 34 - - HYPH cord-273505-pcsw3vmx 115 35 CoV CoV NNP cord-273505-pcsw3vmx 115 36 and and CC cord-273505-pcsw3vmx 115 37 MERS MERS NNP cord-273505-pcsw3vmx 115 38 - - HYPH cord-273505-pcsw3vmx 115 39 CoV CoV NNP cord-273505-pcsw3vmx 115 40 infection infection NN cord-273505-pcsw3vmx 115 41 ( ( -LRB- cord-273505-pcsw3vmx 115 42 99 99 CD cord-273505-pcsw3vmx 115 43 ) ) -RRB- cord-273505-pcsw3vmx 115 44 ( ( -LRB- cord-273505-pcsw3vmx 115 45 100 100 CD cord-273505-pcsw3vmx 115 46 ) ) -RRB- cord-273505-pcsw3vmx 115 47 ( ( -LRB- cord-273505-pcsw3vmx 115 48 101 101 CD cord-273505-pcsw3vmx 115 49 ) ) -RRB- cord-273505-pcsw3vmx 115 50 . . . cord-273505-pcsw3vmx 116 1 The the DT cord-273505-pcsw3vmx 116 2 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 116 3 effects effect NNS cord-273505-pcsw3vmx 116 4 of of IN cord-273505-pcsw3vmx 116 5 IVIg ivig NN cord-273505-pcsw3vmx 116 6 on on IN cord-273505-pcsw3vmx 116 7 DCs dc NNS cord-273505-pcsw3vmx 116 8 differ differ VBP cord-273505-pcsw3vmx 116 9 depending depend VBG cord-273505-pcsw3vmx 116 10 on on IN cord-273505-pcsw3vmx 116 11 dosage dosage NN cord-273505-pcsw3vmx 116 12 . . . cord-273505-pcsw3vmx 117 1 IVIg IVIg NNP cord-273505-pcsw3vmx 117 2 accelerates accelerate VBZ cord-273505-pcsw3vmx 117 3 maturation maturation NN cord-273505-pcsw3vmx 117 4 at at IN cord-273505-pcsw3vmx 117 5 physiological physiological JJ cord-273505-pcsw3vmx 117 6 doses dose NNS cord-273505-pcsw3vmx 117 7 , , , cord-273505-pcsw3vmx 117 8 but but CC cord-273505-pcsw3vmx 117 9 inhibits inhibit VBZ cord-273505-pcsw3vmx 117 10 the the DT cord-273505-pcsw3vmx 117 11 maturation maturation NN cord-273505-pcsw3vmx 117 12 , , , cord-273505-pcsw3vmx 117 13 activation activation NN cord-273505-pcsw3vmx 117 14 , , , cord-273505-pcsw3vmx 117 15 and and CC cord-273505-pcsw3vmx 117 16 function function VB cord-273505-pcsw3vmx 117 17 at at IN cord-273505-pcsw3vmx 117 18 therapeutic therapeutic JJ cord-273505-pcsw3vmx 117 19 doses dose NNS cord-273505-pcsw3vmx 117 20 ( ( -LRB- cord-273505-pcsw3vmx 117 21 102 102 CD cord-273505-pcsw3vmx 117 22 ) ) -RRB- cord-273505-pcsw3vmx 117 23 . . . cord-273505-pcsw3vmx 118 1 High high JJ cord-273505-pcsw3vmx 118 2 - - HYPH cord-273505-pcsw3vmx 118 3 doses dose NNS cord-273505-pcsw3vmx 118 4 IVIg ivig VBP cord-273505-pcsw3vmx 118 5 treated treat VBD cord-273505-pcsw3vmx 118 6 immature immature JJ cord-273505-pcsw3vmx 118 7 DCs dc NNS cord-273505-pcsw3vmx 118 8 secrete secrete JJ cord-273505-pcsw3vmx 118 9 increased increase VBN cord-273505-pcsw3vmx 118 10 levels level NNS cord-273505-pcsw3vmx 118 11 of of IN cord-273505-pcsw3vmx 118 12 anti anti JJ cord-273505-pcsw3vmx 118 13 - - JJ cord-273505-pcsw3vmx 118 14 inflammatory inflammatory JJ cord-273505-pcsw3vmx 118 15 cytokines cytokine NNS cord-273505-pcsw3vmx 118 16 , , , cord-273505-pcsw3vmx 118 17 and and CC cord-273505-pcsw3vmx 118 18 decreased decrease VBD cord-273505-pcsw3vmx 118 19 levels level NNS cord-273505-pcsw3vmx 118 20 of of IN cord-273505-pcsw3vmx 118 21 pro pro JJ cord-273505-pcsw3vmx 118 22 - - JJ cord-273505-pcsw3vmx 118 23 inflammatory inflammatory JJ cord-273505-pcsw3vmx 118 24 cytokines cytokine NNS cord-273505-pcsw3vmx 118 25 ( ( -LRB- cord-273505-pcsw3vmx 118 26 103 103 CD cord-273505-pcsw3vmx 118 27 ) ) -RRB- cord-273505-pcsw3vmx 118 28 . . . cord-273505-pcsw3vmx 119 1 C c NN cord-273505-pcsw3vmx 119 2 - - HYPH cord-273505-pcsw3vmx 119 3 type type NN cord-273505-pcsw3vmx 119 4 lectins lectin NNS cord-273505-pcsw3vmx 119 5 expressed express VBN cord-273505-pcsw3vmx 119 6 on on IN cord-273505-pcsw3vmx 119 7 DCs dc NNS cord-273505-pcsw3vmx 119 8 are be VBP cord-273505-pcsw3vmx 119 9 considered consider VBN cord-273505-pcsw3vmx 119 10 as as IN cord-273505-pcsw3vmx 119 11 possible possible JJ cord-273505-pcsw3vmx 119 12 effector effector NN cord-273505-pcsw3vmx 119 13 targets target NNS cord-273505-pcsw3vmx 119 14 of of IN cord-273505-pcsw3vmx 119 15 IVIg ivig JJ cord-273505-pcsw3vmx 119 16 preparations preparation NNS cord-273505-pcsw3vmx 119 17 , , , cord-273505-pcsw3vmx 119 18 however however RB cord-273505-pcsw3vmx 119 19 , , , cord-273505-pcsw3vmx 119 20 the the DT cord-273505-pcsw3vmx 119 21 exact exact JJ cord-273505-pcsw3vmx 119 22 mechanism mechanism NN cord-273505-pcsw3vmx 119 23 of of IN cord-273505-pcsw3vmx 119 24 action action NN cord-273505-pcsw3vmx 119 25 of of IN cord-273505-pcsw3vmx 119 26 IVIg IVIg NNP cord-273505-pcsw3vmx 119 27 on on IN cord-273505-pcsw3vmx 119 28 DCs DCs NNP cord-273505-pcsw3vmx 119 29 remains remain VBZ cord-273505-pcsw3vmx 119 30 controversial controversial JJ cord-273505-pcsw3vmx 119 31 . . . cord-273505-pcsw3vmx 120 1 As as IN cord-273505-pcsw3vmx 120 2 stated state VBN cord-273505-pcsw3vmx 120 3 , , , cord-273505-pcsw3vmx 120 4 interactions interaction NNS cord-273505-pcsw3vmx 120 5 between between IN cord-273505-pcsw3vmx 120 6 Fc Fc NNP cord-273505-pcsw3vmx 120 7 - - HYPH cord-273505-pcsw3vmx 120 8 sialylated sialylate VBN cord-273505-pcsw3vmx 120 9 IgG IgG NNP cord-273505-pcsw3vmx 120 10 and and CC cord-273505-pcsw3vmx 120 11 DC DC NNP cord-273505-pcsw3vmx 120 12 - - HYPH cord-273505-pcsw3vmx 120 13 SIGN SIGN NNP cord-273505-pcsw3vmx 120 14 failed fail VBD cord-273505-pcsw3vmx 120 15 to to TO cord-273505-pcsw3vmx 120 16 reproduce reproduce VB cord-273505-pcsw3vmx 120 17 in in IN cord-273505-pcsw3vmx 120 18 human human JJ cord-273505-pcsw3vmx 120 19 cells cell NNS cord-273505-pcsw3vmx 120 20 , , , cord-273505-pcsw3vmx 120 21 and and CC cord-273505-pcsw3vmx 120 22 the the DT cord-273505-pcsw3vmx 120 23 expression expression NN cord-273505-pcsw3vmx 120 24 of of IN cord-273505-pcsw3vmx 120 25 FcγRIIB FcγRIIB NNP cord-273505-pcsw3vmx 120 26 remains remain VBZ cord-273505-pcsw3vmx 120 27 stable stable JJ cord-273505-pcsw3vmx 120 28 on on IN cord-273505-pcsw3vmx 120 29 DCs dc NNS cord-273505-pcsw3vmx 120 30 after after IN cord-273505-pcsw3vmx 120 31 IVIg IVIg NNP cord-273505-pcsw3vmx 120 32 treatment treatment NN cord-273505-pcsw3vmx 120 33 ( ( -LRB- cord-273505-pcsw3vmx 120 34 104 104 CD cord-273505-pcsw3vmx 120 35 ) ) -RRB- cord-273505-pcsw3vmx 120 36 . . . cord-273505-pcsw3vmx 121 1 Another another DT cord-273505-pcsw3vmx 121 2 C c NN cord-273505-pcsw3vmx 121 3 - - HYPH cord-273505-pcsw3vmx 121 4 type type NN cord-273505-pcsw3vmx 121 5 lectin lectin NN cord-273505-pcsw3vmx 121 6 , , , cord-273505-pcsw3vmx 121 7 DRIC DRIC NNP cord-273505-pcsw3vmx 121 8 , , , cord-273505-pcsw3vmx 121 9 has have VBZ cord-273505-pcsw3vmx 121 10 also also RB cord-273505-pcsw3vmx 121 11 been be VBN cord-273505-pcsw3vmx 121 12 identified identify VBN cord-273505-pcsw3vmx 121 13 to to TO cord-273505-pcsw3vmx 121 14 bind bind VB cord-273505-pcsw3vmx 121 15 to to IN cord-273505-pcsw3vmx 121 16 Fc Fc NNP cord-273505-pcsw3vmx 121 17 - - HYPH cord-273505-pcsw3vmx 121 18 sialylated sialylate VBN cord-273505-pcsw3vmx 121 19 IgG igg NN cord-273505-pcsw3vmx 121 20 and and CC cord-273505-pcsw3vmx 121 21 further further RB cord-273505-pcsw3vmx 121 22 mediates mediate VBZ cord-273505-pcsw3vmx 121 23 the the DT cord-273505-pcsw3vmx 121 24 induction induction NN cord-273505-pcsw3vmx 121 25 of of IN cord-273505-pcsw3vmx 121 26 Treg Treg NNP cord-273505-pcsw3vmx 121 27 cells cell NNS cord-273505-pcsw3vmx 121 28 in in IN cord-273505-pcsw3vmx 121 29 a a DT cord-273505-pcsw3vmx 121 30 mouse mouse NN cord-273505-pcsw3vmx 121 31 model model NN cord-273505-pcsw3vmx 121 32 ( ( -LRB- cord-273505-pcsw3vmx 121 33 105 105 CD cord-273505-pcsw3vmx 121 34 ) ) -RRB- cord-273505-pcsw3vmx 121 35 . . . cord-273505-pcsw3vmx 122 1 Additionally additionally RB cord-273505-pcsw3vmx 122 2 , , , cord-273505-pcsw3vmx 122 3 an an DT cord-273505-pcsw3vmx 122 4 increased increase VBN cord-273505-pcsw3vmx 122 5 accumulation accumulation NN cord-273505-pcsw3vmx 122 6 of of IN cord-273505-pcsw3vmx 122 7 lipids lipid NNS cord-273505-pcsw3vmx 122 8 and and CC cord-273505-pcsw3vmx 122 9 decreased decrease VBD cord-273505-pcsw3vmx 122 10 expression expression NN cord-273505-pcsw3vmx 122 11 of of IN cord-273505-pcsw3vmx 122 12 MHC MHC NNP cord-273505-pcsw3vmx 122 13 - - HYPH cord-273505-pcsw3vmx 122 14 II II NNP cord-273505-pcsw3vmx 122 15 , , , cord-273505-pcsw3vmx 122 16 CD40 CD40 NNP cord-273505-pcsw3vmx 122 17 , , , cord-273505-pcsw3vmx 122 18 CD80 CD80 NNP cord-273505-pcsw3vmx 122 19 / / SYM cord-273505-pcsw3vmx 122 20 CD86 CD86 NNP cord-273505-pcsw3vmx 122 21 , , , cord-273505-pcsw3vmx 122 22 and and CC cord-273505-pcsw3vmx 122 23 IFN IFN NNP cord-273505-pcsw3vmx 122 24 - - HYPH cord-273505-pcsw3vmx 122 25 γR2 γR2 NNP cord-273505-pcsw3vmx 122 26 on on IN cord-273505-pcsw3vmx 122 27 DCs dc NNS cord-273505-pcsw3vmx 122 28 upon upon IN cord-273505-pcsw3vmx 122 29 high high JJ cord-273505-pcsw3vmx 122 30 - - HYPH cord-273505-pcsw3vmx 122 31 doses dose NNS cord-273505-pcsw3vmx 122 32 IVIg ivig NN cord-273505-pcsw3vmx 122 33 treatment treatment NN cord-273505-pcsw3vmx 122 34 might may MD cord-273505-pcsw3vmx 122 35 suppress suppress VB cord-273505-pcsw3vmx 122 36 antigen antigen NN cord-273505-pcsw3vmx 122 37 presentation presentation NN cord-273505-pcsw3vmx 122 38 and and CC cord-273505-pcsw3vmx 122 39 allogeneic allogeneic IN cord-273505-pcsw3vmx 122 40 T t NN cord-273505-pcsw3vmx 122 41 - - HYPH cord-273505-pcsw3vmx 122 42 cell cell NN cord-273505-pcsw3vmx 122 43 stimulatory stimulatory JJ cord-273505-pcsw3vmx 122 44 capacity capacity NN cord-273505-pcsw3vmx 122 45 , , , cord-273505-pcsw3vmx 122 46 contributing contribute VBG cord-273505-pcsw3vmx 122 47 to to IN cord-273505-pcsw3vmx 122 48 a a DT cord-273505-pcsw3vmx 122 49 negative negative JJ cord-273505-pcsw3vmx 122 50 regulation regulation NN cord-273505-pcsw3vmx 122 51 of of IN cord-273505-pcsw3vmx 122 52 the the DT cord-273505-pcsw3vmx 122 53 immune immune JJ cord-273505-pcsw3vmx 122 54 response response NN cord-273505-pcsw3vmx 122 55 ( ( -LRB- cord-273505-pcsw3vmx 122 56 104 104 CD cord-273505-pcsw3vmx 122 57 , , , cord-273505-pcsw3vmx 122 58 106 106 CD cord-273505-pcsw3vmx 122 59 , , , cord-273505-pcsw3vmx 122 60 107 107 CD cord-273505-pcsw3vmx 122 61 ) ) -RRB- cord-273505-pcsw3vmx 122 62 . . . cord-273505-pcsw3vmx 123 1 Whether whether IN cord-273505-pcsw3vmx 123 2 infiltrating infiltrate VBG cord-273505-pcsw3vmx 123 3 inflammatory inflammatory JJ cord-273505-pcsw3vmx 123 4 monocyte monocyte NN cord-273505-pcsw3vmx 123 5 - - HYPH cord-273505-pcsw3vmx 123 6 macrophages macrophage NNS cord-273505-pcsw3vmx 123 7 ( ( -LRB- cord-273505-pcsw3vmx 123 8 IMM IMM NNP cord-273505-pcsw3vmx 123 9 ) ) -RRB- cord-273505-pcsw3vmx 123 10 are be VBP cord-273505-pcsw3vmx 123 11 beneficial beneficial JJ cord-273505-pcsw3vmx 123 12 or or CC cord-273505-pcsw3vmx 123 13 deleterious deleterious JJ cord-273505-pcsw3vmx 123 14 after after IN cord-273505-pcsw3vmx 123 15 a a DT cord-273505-pcsw3vmx 123 16 viral viral JJ cord-273505-pcsw3vmx 123 17 infection infection NN cord-273505-pcsw3vmx 123 18 is be VBZ cord-273505-pcsw3vmx 123 19 mainly mainly RB cord-273505-pcsw3vmx 123 20 dependent dependent JJ cord-273505-pcsw3vmx 123 21 on on IN cord-273505-pcsw3vmx 123 22 their -PRON- PRP$ cord-273505-pcsw3vmx 123 23 ability ability NN cord-273505-pcsw3vmx 123 24 to to TO cord-273505-pcsw3vmx 123 25 secrete secrete VB cord-273505-pcsw3vmx 123 26 inflammatory inflammatory JJ cord-273505-pcsw3vmx 123 27 cytokines cytokine NNS cord-273505-pcsw3vmx 123 28 and and CC cord-273505-pcsw3vmx 123 29 chemokines chemokine NNS cord-273505-pcsw3vmx 123 30 . . . cord-273505-pcsw3vmx 124 1 A a DT cord-273505-pcsw3vmx 124 2 dysregulated dysregulated JJ cord-273505-pcsw3vmx 124 3 cytokine cytokine NN cord-273505-pcsw3vmx 124 4 response response NN cord-273505-pcsw3vmx 124 5 can can MD cord-273505-pcsw3vmx 124 6 also also RB cord-273505-pcsw3vmx 124 7 promote promote VB cord-273505-pcsw3vmx 124 8 excessive excessive JJ cord-273505-pcsw3vmx 124 9 activation activation NN cord-273505-pcsw3vmx 124 10 of of IN cord-273505-pcsw3vmx 124 11 IMM IMM NNP cord-273505-pcsw3vmx 124 12 , , , cord-273505-pcsw3vmx 124 13 leading lead VBG cord-273505-pcsw3vmx 124 14 to to IN cord-273505-pcsw3vmx 124 15 immunopathological immunopathological JJ cord-273505-pcsw3vmx 124 16 effects effect NNS cord-273505-pcsw3vmx 124 17 on on IN cord-273505-pcsw3vmx 124 18 healthy healthy JJ cord-273505-pcsw3vmx 124 19 tissues tissue NNS cord-273505-pcsw3vmx 124 20 . . . cord-273505-pcsw3vmx 125 1 Macrophage macrophage NN cord-273505-pcsw3vmx 125 2 activation activation NN cord-273505-pcsw3vmx 125 3 syndrome syndrome NN cord-273505-pcsw3vmx 125 4 ( ( -LRB- cord-273505-pcsw3vmx 125 5 MAS MAS NNP cord-273505-pcsw3vmx 125 6 ) ) -RRB- cord-273505-pcsw3vmx 125 7 was be VBD cord-273505-pcsw3vmx 125 8 reported report VBN cord-273505-pcsw3vmx 125 9 in in IN cord-273505-pcsw3vmx 125 10 several several JJ cord-273505-pcsw3vmx 125 11 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 125 12 patients patient NNS cord-273505-pcsw3vmx 125 13 with with IN cord-273505-pcsw3vmx 125 14 severe severe JJ cord-273505-pcsw3vmx 125 15 respiratory respiratory JJ cord-273505-pcsw3vmx 125 16 failure failure NN cord-273505-pcsw3vmx 125 17 , , , cord-273505-pcsw3vmx 125 18 and and CC cord-273505-pcsw3vmx 125 19 the the DT cord-273505-pcsw3vmx 125 20 production production NN cord-273505-pcsw3vmx 125 21 of of IN cord-273505-pcsw3vmx 125 22 associated associated JJ cord-273505-pcsw3vmx 125 23 pro pro JJ cord-273505-pcsw3vmx 125 24 - - JJ cord-273505-pcsw3vmx 125 25 inflammatory inflammatory JJ cord-273505-pcsw3vmx 125 26 cytokines cytokine NNS cord-273505-pcsw3vmx 125 27 ( ( -LRB- cord-273505-pcsw3vmx 125 28 IL-6 IL-6 NNP cord-273505-pcsw3vmx 125 29 and and CC cord-273505-pcsw3vmx 125 30 TNFα TNFα NNP cord-273505-pcsw3vmx 125 31 ) ) -RRB- cord-273505-pcsw3vmx 125 32 might may MD cord-273505-pcsw3vmx 125 33 contribute contribute VB cord-273505-pcsw3vmx 125 34 to to IN cord-273505-pcsw3vmx 125 35 hyper hyper JJ cord-273505-pcsw3vmx 125 36 - - JJ cord-273505-pcsw3vmx 125 37 inflammatory inflammatory JJ cord-273505-pcsw3vmx 125 38 conditions condition NNS cord-273505-pcsw3vmx 125 39 ( ( -LRB- cord-273505-pcsw3vmx 125 40 108 108 CD cord-273505-pcsw3vmx 125 41 ) ) -RRB- cord-273505-pcsw3vmx 125 42 . . . cord-273505-pcsw3vmx 126 1 It -PRON- PRP cord-273505-pcsw3vmx 126 2 was be VBD cord-273505-pcsw3vmx 126 3 also also RB cord-273505-pcsw3vmx 126 4 detected detect VBN cord-273505-pcsw3vmx 126 5 that that IN cord-273505-pcsw3vmx 126 6 SARS SARS NNP cord-273505-pcsw3vmx 126 7 - - HYPH cord-273505-pcsw3vmx 126 8 CoV-2 CoV-2 NNP cord-273505-pcsw3vmx 126 9 infects infect VBZ cord-273505-pcsw3vmx 126 10 macrophages macrophage NNS cord-273505-pcsw3vmx 126 11 and and CC cord-273505-pcsw3vmx 126 12 triggers trigger VBZ cord-273505-pcsw3vmx 126 13 secretion secretion NN cord-273505-pcsw3vmx 126 14 of of IN cord-273505-pcsw3vmx 126 15 IL-6 IL-6 NNP cord-273505-pcsw3vmx 126 16 , , , cord-273505-pcsw3vmx 126 17 which which WDT cord-273505-pcsw3vmx 126 18 might may MD cord-273505-pcsw3vmx 126 19 contribute contribute VB cord-273505-pcsw3vmx 126 20 to to IN cord-273505-pcsw3vmx 126 21 lymphocyte lymphocyte NN cord-273505-pcsw3vmx 126 22 apoptosis apoptosis NN cord-273505-pcsw3vmx 126 23 , , , cord-273505-pcsw3vmx 126 24 suggesting suggest VBG cord-273505-pcsw3vmx 126 25 an an DT cord-273505-pcsw3vmx 126 26 excessive excessive JJ cord-273505-pcsw3vmx 126 27 infiltration infiltration NN cord-273505-pcsw3vmx 126 28 and and CC cord-273505-pcsw3vmx 126 29 intense intense JJ cord-273505-pcsw3vmx 126 30 pro pro JJ cord-273505-pcsw3vmx 126 31 - - JJ cord-273505-pcsw3vmx 126 32 inflammatory inflammatory JJ cord-273505-pcsw3vmx 126 33 activity activity NN cord-273505-pcsw3vmx 126 34 of of IN cord-273505-pcsw3vmx 126 35 IMM IMM NNP cord-273505-pcsw3vmx 126 36 in in IN cord-273505-pcsw3vmx 126 37 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 126 38 patients patient NNS cord-273505-pcsw3vmx 126 39 ( ( -LRB- cord-273505-pcsw3vmx 126 40 109 109 CD cord-273505-pcsw3vmx 126 41 ) ) -RRB- cord-273505-pcsw3vmx 126 42 . . . cord-273505-pcsw3vmx 127 1 Increased increase VBN cord-273505-pcsw3vmx 127 2 pathogenic pathogenic JJ cord-273505-pcsw3vmx 127 3 IMM IMM NNP cord-273505-pcsw3vmx 127 4 influx influx NN cord-273505-pcsw3vmx 127 5 has have VBZ cord-273505-pcsw3vmx 127 6 been be VBN cord-273505-pcsw3vmx 127 7 consistently consistently RB cord-273505-pcsw3vmx 127 8 observed observe VBN cord-273505-pcsw3vmx 127 9 in in IN cord-273505-pcsw3vmx 127 10 severe severe JJ cord-273505-pcsw3vmx 127 11 or or CC cord-273505-pcsw3vmx 127 12 lethal lethal JJ cord-273505-pcsw3vmx 127 13 SARS SARS NNP cord-273505-pcsw3vmx 127 14 patients patient NNS cord-273505-pcsw3vmx 127 15 , , , cord-273505-pcsw3vmx 127 16 along along IN cord-273505-pcsw3vmx 127 17 with with IN cord-273505-pcsw3vmx 127 18 mice mouse NNS cord-273505-pcsw3vmx 127 19 and and CC cord-273505-pcsw3vmx 127 20 Chinese chinese JJ cord-273505-pcsw3vmx 127 21 rhesus rhesu NNS cord-273505-pcsw3vmx 127 22 macaque macaque NN cord-273505-pcsw3vmx 127 23 models model NNS cord-273505-pcsw3vmx 127 24 ( ( -LRB- cord-273505-pcsw3vmx 127 25 101 101 CD cord-273505-pcsw3vmx 127 26 , , , cord-273505-pcsw3vmx 127 27 110 110 CD cord-273505-pcsw3vmx 127 28 ) ) -RRB- cord-273505-pcsw3vmx 127 29 . . . cord-273505-pcsw3vmx 128 1 The the DT cord-273505-pcsw3vmx 128 2 activation activation NN cord-273505-pcsw3vmx 128 3 of of IN cord-273505-pcsw3vmx 128 4 macrophages macrophage NNS cord-273505-pcsw3vmx 128 5 by by IN cord-273505-pcsw3vmx 128 6 SARS SARS NNP cord-273505-pcsw3vmx 128 7 - - HYPH cord-273505-pcsw3vmx 128 8 CoV CoV NNP cord-273505-pcsw3vmx 128 9 occurs occur VBZ cord-273505-pcsw3vmx 128 10 by by IN cord-273505-pcsw3vmx 128 11 TLR2 TLR2 NNP cord-273505-pcsw3vmx 128 12 ligand ligand NN cord-273505-pcsw3vmx 128 13 recognition recognition NN cord-273505-pcsw3vmx 128 14 , , , cord-273505-pcsw3vmx 128 15 subsequent subsequent JJ cord-273505-pcsw3vmx 128 16 activation activation NN cord-273505-pcsw3vmx 128 17 of of IN cord-273505-pcsw3vmx 128 18 the the DT cord-273505-pcsw3vmx 128 19 NF nf NN cord-273505-pcsw3vmx 128 20 - - HYPH cord-273505-pcsw3vmx 128 21 κB κB NNP cord-273505-pcsw3vmx 128 22 pathway pathway NN cord-273505-pcsw3vmx 128 23 and and CC cord-273505-pcsw3vmx 128 24 secretion secretion NN cord-273505-pcsw3vmx 128 25 of of IN cord-273505-pcsw3vmx 128 26 cytokines cytokine NNS cord-273505-pcsw3vmx 128 27 , , , cord-273505-pcsw3vmx 128 28 contributing contribute VBG cord-273505-pcsw3vmx 128 29 to to IN cord-273505-pcsw3vmx 128 30 the the DT cord-273505-pcsw3vmx 128 31 immunopathology immunopathology NN cord-273505-pcsw3vmx 128 32 of of IN cord-273505-pcsw3vmx 128 33 SARS SARS NNP cord-273505-pcsw3vmx 128 34 ( ( -LRB- cord-273505-pcsw3vmx 128 35 111 111 CD cord-273505-pcsw3vmx 128 36 ) ) -RRB- cord-273505-pcsw3vmx 128 37 ( ( -LRB- cord-273505-pcsw3vmx 128 38 112 112 CD cord-273505-pcsw3vmx 128 39 ) ) -RRB- cord-273505-pcsw3vmx 128 40 ( ( -LRB- cord-273505-pcsw3vmx 128 41 113 113 CD cord-273505-pcsw3vmx 128 42 ) ) -RRB- cord-273505-pcsw3vmx 128 43 . . . cord-273505-pcsw3vmx 129 1 High high JJ cord-273505-pcsw3vmx 129 2 - - HYPH cord-273505-pcsw3vmx 129 3 dose dose NN cord-273505-pcsw3vmx 129 4 IVIg ivig NN cord-273505-pcsw3vmx 129 5 therapy therapy NN cord-273505-pcsw3vmx 129 6 is be VBZ cord-273505-pcsw3vmx 129 7 widely widely RB cord-273505-pcsw3vmx 129 8 used use VBN cord-273505-pcsw3vmx 129 9 for for IN cord-273505-pcsw3vmx 129 10 treatment treatment NN cord-273505-pcsw3vmx 129 11 of of IN cord-273505-pcsw3vmx 129 12 patients patient NNS cord-273505-pcsw3vmx 129 13 with with IN cord-273505-pcsw3vmx 129 14 autoimmune autoimmune JJ cord-273505-pcsw3vmx 129 15 diseases disease NNS cord-273505-pcsw3vmx 129 16 complicated complicate VBN cord-273505-pcsw3vmx 129 17 by by IN cord-273505-pcsw3vmx 129 18 MAS MAS NNP cord-273505-pcsw3vmx 129 19 ( ( -LRB- cord-273505-pcsw3vmx 129 20 114 114 CD cord-273505-pcsw3vmx 129 21 ) ) -RRB- cord-273505-pcsw3vmx 129 22 ( ( -LRB- cord-273505-pcsw3vmx 129 23 115 115 CD cord-273505-pcsw3vmx 129 24 ) ) -RRB- cord-273505-pcsw3vmx 129 25 ( ( -LRB- cord-273505-pcsw3vmx 129 26 116 116 CD cord-273505-pcsw3vmx 129 27 ) ) -RRB- cord-273505-pcsw3vmx 129 28 ( ( -LRB- cord-273505-pcsw3vmx 129 29 117 117 CD cord-273505-pcsw3vmx 129 30 ) ) -RRB- cord-273505-pcsw3vmx 129 31 ( ( -LRB- cord-273505-pcsw3vmx 129 32 118 118 CD cord-273505-pcsw3vmx 129 33 ) ) -RRB- cord-273505-pcsw3vmx 129 34 . . . cord-273505-pcsw3vmx 130 1 For for IN cord-273505-pcsw3vmx 130 2 inhibitory inhibitory JJ cord-273505-pcsw3vmx 130 3 effects effect NNS cord-273505-pcsw3vmx 130 4 of of IN cord-273505-pcsw3vmx 130 5 IVIgs IVIgs NNP cord-273505-pcsw3vmx 130 6 , , , cord-273505-pcsw3vmx 130 7 functionally functionally RB cord-273505-pcsw3vmx 130 8 activating activate VBG cord-273505-pcsw3vmx 130 9 FcγRs FcγRs NNP cord-273505-pcsw3vmx 130 10 are be VBP cord-273505-pcsw3vmx 130 11 required require VBN cord-273505-pcsw3vmx 130 12 to to TO cord-273505-pcsw3vmx 130 13 acquire acquire VB cord-273505-pcsw3vmx 130 14 a a DT cord-273505-pcsw3vmx 130 15 cross cross JJ cord-273505-pcsw3vmx 130 16 - - JJ cord-273505-pcsw3vmx 130 17 tolerant tolerant JJ cord-273505-pcsw3vmx 130 18 state state NN cord-273505-pcsw3vmx 130 19 of of IN cord-273505-pcsw3vmx 130 20 mouse mouse NN cord-273505-pcsw3vmx 130 21 macrophages macrophage NNS cord-273505-pcsw3vmx 130 22 ( ( -LRB- cord-273505-pcsw3vmx 130 23 119 119 CD cord-273505-pcsw3vmx 130 24 ) ) -RRB- cord-273505-pcsw3vmx 130 25 . . . cord-273505-pcsw3vmx 131 1 In in IN cord-273505-pcsw3vmx 131 2 vitro vitro FW cord-273505-pcsw3vmx 131 3 , , , cord-273505-pcsw3vmx 131 4 IVIg IVIg NNP cord-273505-pcsw3vmx 131 5 inhibits inhibit VBZ cord-273505-pcsw3vmx 131 6 the the DT cord-273505-pcsw3vmx 131 7 production production NN cord-273505-pcsw3vmx 131 8 of of IN cord-273505-pcsw3vmx 131 9 pro pro JJ cord-273505-pcsw3vmx 131 10 - - JJ cord-273505-pcsw3vmx 131 11 inflammatory inflammatory JJ cord-273505-pcsw3vmx 131 12 cytokines cytokine NNS cord-273505-pcsw3vmx 131 13 by by IN cord-273505-pcsw3vmx 131 14 M1 M1 NNP cord-273505-pcsw3vmx 131 15 macrophages macrophage NNS cord-273505-pcsw3vmx 131 16 and and CC cord-273505-pcsw3vmx 131 17 triggers trigger VBZ cord-273505-pcsw3vmx 131 18 macrophage macrophage NN cord-273505-pcsw3vmx 131 19 polarization polarization NN cord-273505-pcsw3vmx 131 20 via via IN cord-273505-pcsw3vmx 131 21 FcγRIIImediated fcγriiimediated JJ cord-273505-pcsw3vmx 131 22 mechanisms mechanism NNS cord-273505-pcsw3vmx 131 23 ( ( -LRB- cord-273505-pcsw3vmx 131 24 120 120 CD cord-273505-pcsw3vmx 131 25 ) ) -RRB- cord-273505-pcsw3vmx 131 26 . . . cord-273505-pcsw3vmx 132 1 IVIg IVIg NNP cord-273505-pcsw3vmx 132 2 limits limit VBZ cord-273505-pcsw3vmx 132 3 the the DT cord-273505-pcsw3vmx 132 4 differentiation differentiation NN cord-273505-pcsw3vmx 132 5 of of IN cord-273505-pcsw3vmx 132 6 macrophages macrophage NNS cord-273505-pcsw3vmx 132 7 through through IN cord-273505-pcsw3vmx 132 8 inhibition inhibition NN cord-273505-pcsw3vmx 132 9 of of IN cord-273505-pcsw3vmx 132 10 GM GM NNP cord-273505-pcsw3vmx 132 11 - - HYPH cord-273505-pcsw3vmx 132 12 CSF csf NN cord-273505-pcsw3vmx 132 13 - - HYPH cord-273505-pcsw3vmx 132 14 driven drive VBN cord-273505-pcsw3vmx 132 15 STAT5 stat5 NN cord-273505-pcsw3vmx 132 16 activation activation NN cord-273505-pcsw3vmx 132 17 by by IN cord-273505-pcsw3vmx 132 18 FcγR fcγr JJ cord-273505-pcsw3vmx 132 19 - - HYPH cord-273505-pcsw3vmx 132 20 dependent dependent JJ cord-273505-pcsw3vmx 132 21 mechanisms mechanism NNS cord-273505-pcsw3vmx 132 22 ( ( -LRB- cord-273505-pcsw3vmx 132 23 119 119 CD cord-273505-pcsw3vmx 132 24 ) ) -RRB- cord-273505-pcsw3vmx 132 25 . . . cord-273505-pcsw3vmx 133 1 An an DT cord-273505-pcsw3vmx 133 2 increased increase VBN cord-273505-pcsw3vmx 133 3 production production NN cord-273505-pcsw3vmx 133 4 of of IN cord-273505-pcsw3vmx 133 5 anti anti JJ cord-273505-pcsw3vmx 133 6 - - JJ cord-273505-pcsw3vmx 133 7 inflammatory inflammatory JJ cord-273505-pcsw3vmx 133 8 cytokines cytokine NNS cord-273505-pcsw3vmx 133 9 of of IN cord-273505-pcsw3vmx 133 10 LPS LPS NNP cord-273505-pcsw3vmx 133 11 - - HYPH cord-273505-pcsw3vmx 133 12 stimulated stimulate VBN cord-273505-pcsw3vmx 133 13 monocytes monocyte NNS cord-273505-pcsw3vmx 133 14 ( ( -LRB- cord-273505-pcsw3vmx 133 15 especially especially RB cord-273505-pcsw3vmx 133 16 IL-10 IL-10 NNP cord-273505-pcsw3vmx 133 17 ) ) -RRB- cord-273505-pcsw3vmx 133 18 is be VBZ cord-273505-pcsw3vmx 133 19 further further RB cord-273505-pcsw3vmx 133 20 enhanced enhance VBN cord-273505-pcsw3vmx 133 21 by by IN cord-273505-pcsw3vmx 133 22 IVIg IVIg VBN cord-273505-pcsw3vmx 133 23 through through IN cord-273505-pcsw3vmx 133 24 phosphorylation phosphorylation NN cord-273505-pcsw3vmx 133 25 of of IN cord-273505-pcsw3vmx 133 26 ERK1 ERK1 NNP cord-273505-pcsw3vmx 133 27 / / SYM cord-273505-pcsw3vmx 133 28 ERK2 ERK2 NNP cord-273505-pcsw3vmx 133 29 and and CC cord-273505-pcsw3vmx 133 30 P38 P38 NNP cord-273505-pcsw3vmx 133 31 / / SYM cord-273505-pcsw3vmx 133 32 MAPK MAPK NNP cord-273505-pcsw3vmx 133 33 via via IN cord-273505-pcsw3vmx 133 34 FcγRIIA fcγriia NN cord-273505-pcsw3vmx 133 35 - - HYPH cord-273505-pcsw3vmx 133 36 mediated mediate VBN cord-273505-pcsw3vmx 133 37 mechanisms mechanism NNS cord-273505-pcsw3vmx 133 38 ( ( -LRB- cord-273505-pcsw3vmx 133 39 121 121 CD cord-273505-pcsw3vmx 133 40 ) ) -RRB- cord-273505-pcsw3vmx 133 41 . . . cord-273505-pcsw3vmx 134 1 Neutrophils neutrophil NNS cord-273505-pcsw3vmx 134 2 are be VBP cord-273505-pcsw3vmx 134 3 the the DT cord-273505-pcsw3vmx 134 4 most most RBS cord-273505-pcsw3vmx 134 5 abundant abundant JJ cord-273505-pcsw3vmx 134 6 type type NN cord-273505-pcsw3vmx 134 7 of of IN cord-273505-pcsw3vmx 134 8 granulocytes granulocyte NNS cord-273505-pcsw3vmx 134 9 in in IN cord-273505-pcsw3vmx 134 10 peripheral peripheral JJ cord-273505-pcsw3vmx 134 11 blood blood NN cord-273505-pcsw3vmx 134 12 and and CC cord-273505-pcsw3vmx 134 13 constitute constitute VB cord-273505-pcsw3vmx 134 14 an an DT cord-273505-pcsw3vmx 134 15 essential essential JJ cord-273505-pcsw3vmx 134 16 part part NN cord-273505-pcsw3vmx 134 17 of of IN cord-273505-pcsw3vmx 134 18 innate innate JJ cord-273505-pcsw3vmx 134 19 immunity immunity NN cord-273505-pcsw3vmx 134 20 . . . cord-273505-pcsw3vmx 135 1 The the DT cord-273505-pcsw3vmx 135 2 release release NN cord-273505-pcsw3vmx 135 3 of of IN cord-273505-pcsw3vmx 135 4 cytokines cytokine NNS cord-273505-pcsw3vmx 135 5 , , , cord-273505-pcsw3vmx 135 6 nitric nitric NN cord-273505-pcsw3vmx 135 7 oxide oxide NN cord-273505-pcsw3vmx 135 8 , , , cord-273505-pcsw3vmx 135 9 reactive reactive JJ cord-273505-pcsw3vmx 135 10 oxygen oxygen NN cord-273505-pcsw3vmx 135 11 species specie NNS cord-273505-pcsw3vmx 135 12 ( ( -LRB- cord-273505-pcsw3vmx 135 13 ROS ROS NNP cord-273505-pcsw3vmx 135 14 ) ) -RRB- cord-273505-pcsw3vmx 135 15 , , , cord-273505-pcsw3vmx 135 16 and and CC cord-273505-pcsw3vmx 135 17 neutrophil neutrophil NN cord-273505-pcsw3vmx 135 18 extracellular extracellular JJ cord-273505-pcsw3vmx 135 19 traps trap NNS cord-273505-pcsw3vmx 135 20 ( ( -LRB- cord-273505-pcsw3vmx 135 21 NET net NN cord-273505-pcsw3vmx 135 22 ) ) -RRB- cord-273505-pcsw3vmx 135 23 by by IN cord-273505-pcsw3vmx 135 24 neutrophils neutrophil NNS cord-273505-pcsw3vmx 135 25 can can MD cord-273505-pcsw3vmx 135 26 help help VB cord-273505-pcsw3vmx 135 27 to to TO cord-273505-pcsw3vmx 135 28 neutralize neutralize VB cord-273505-pcsw3vmx 135 29 pathogens pathogen NNS cord-273505-pcsw3vmx 135 30 . . . cord-273505-pcsw3vmx 136 1 Paradoxically paradoxically RB cord-273505-pcsw3vmx 136 2 , , , cord-273505-pcsw3vmx 136 3 however however RB cord-273505-pcsw3vmx 136 4 , , , cord-273505-pcsw3vmx 136 5 neutrophil neutrophil NN cord-273505-pcsw3vmx 136 6 reactivity reactivity NN cord-273505-pcsw3vmx 136 7 can can MD cord-273505-pcsw3vmx 136 8 also also RB cord-273505-pcsw3vmx 136 9 enhance enhance VB cord-273505-pcsw3vmx 136 10 tissue tissue NN cord-273505-pcsw3vmx 136 11 damage damage NN cord-273505-pcsw3vmx 136 12 in in IN cord-273505-pcsw3vmx 136 13 hyper hyper JJ cord-273505-pcsw3vmx 136 14 - - JJ cord-273505-pcsw3vmx 136 15 inflammatory inflammatory JJ cord-273505-pcsw3vmx 136 16 conditions condition NNS cord-273505-pcsw3vmx 136 17 such such JJ cord-273505-pcsw3vmx 136 18 as as IN cord-273505-pcsw3vmx 136 19 severe severe JJ cord-273505-pcsw3vmx 136 20 virus virus NN cord-273505-pcsw3vmx 136 21 infection infection NN cord-273505-pcsw3vmx 136 22 . . . cord-273505-pcsw3vmx 137 1 Excessive excessive JJ cord-273505-pcsw3vmx 137 2 neutrophils neutrophil NNS cord-273505-pcsw3vmx 137 3 and and CC cord-273505-pcsw3vmx 137 4 NET net NN cord-273505-pcsw3vmx 137 5 production production NN cord-273505-pcsw3vmx 137 6 are be VBP cord-273505-pcsw3vmx 137 7 considered consider VBN cord-273505-pcsw3vmx 137 8 a a DT cord-273505-pcsw3vmx 137 9 potential potential JJ cord-273505-pcsw3vmx 137 10 predictor predictor NN cord-273505-pcsw3vmx 137 11 of of IN cord-273505-pcsw3vmx 137 12 prognosis prognosis NN cord-273505-pcsw3vmx 137 13 in in IN cord-273505-pcsw3vmx 137 14 influenza influenza NN cord-273505-pcsw3vmx 137 15 ( ( -LRB- cord-273505-pcsw3vmx 137 16 122 122 CD cord-273505-pcsw3vmx 137 17 , , , cord-273505-pcsw3vmx 137 18 123 123 CD cord-273505-pcsw3vmx 137 19 ) ) -RRB- cord-273505-pcsw3vmx 137 20 . . . cord-273505-pcsw3vmx 138 1 Similarly similarly RB cord-273505-pcsw3vmx 138 2 , , , cord-273505-pcsw3vmx 138 3 it -PRON- PRP cord-273505-pcsw3vmx 138 4 has have VBZ cord-273505-pcsw3vmx 138 5 been be VBN cord-273505-pcsw3vmx 138 6 considered consider VBN cord-273505-pcsw3vmx 138 7 that that IN cord-273505-pcsw3vmx 138 8 neutrophils neutrophil NNS cord-273505-pcsw3vmx 138 9 in in IN cord-273505-pcsw3vmx 138 10 SARS SARS NNP cord-273505-pcsw3vmx 138 11 - - HYPH cord-273505-pcsw3vmx 138 12 CoV-2 CoV-2 NNP cord-273505-pcsw3vmx 138 13 may may MD cord-273505-pcsw3vmx 138 14 induce induce VB cord-273505-pcsw3vmx 138 15 NETs net NNS cord-273505-pcsw3vmx 138 16 and and CC cord-273505-pcsw3vmx 138 17 contribute contribute VB cord-273505-pcsw3vmx 138 18 to to IN cord-273505-pcsw3vmx 138 19 organ organ NN cord-273505-pcsw3vmx 138 20 damage damage NN cord-273505-pcsw3vmx 138 21 ( ( -LRB- cord-273505-pcsw3vmx 138 22 124 124 CD cord-273505-pcsw3vmx 138 23 , , , cord-273505-pcsw3vmx 138 24 125 125 CD cord-273505-pcsw3vmx 138 25 ) ) -RRB- cord-273505-pcsw3vmx 138 26 . . . cord-273505-pcsw3vmx 139 1 High high JJ cord-273505-pcsw3vmx 139 2 levels level NNS cord-273505-pcsw3vmx 139 3 of of IN cord-273505-pcsw3vmx 139 4 NET net JJ cord-273505-pcsw3vmx 139 5 biomarkers biomarker NNS cord-273505-pcsw3vmx 139 6 ( ( -LRB- cord-273505-pcsw3vmx 139 7 e.g. e.g. RB cord-273505-pcsw3vmx 139 8 , , , cord-273505-pcsw3vmx 139 9 cell cell NN cord-273505-pcsw3vmx 139 10 - - HYPH cord-273505-pcsw3vmx 139 11 free free JJ cord-273505-pcsw3vmx 139 12 DNA dna NN cord-273505-pcsw3vmx 139 13 , , , cord-273505-pcsw3vmx 139 14 myeloperoxidase myeloperoxidase NN cord-273505-pcsw3vmx 139 15 - - HYPH cord-273505-pcsw3vmx 139 16 DNA dna NN cord-273505-pcsw3vmx 139 17 , , , cord-273505-pcsw3vmx 139 18 and and CC cord-273505-pcsw3vmx 139 19 citrullinated citrullinate VBD cord-273505-pcsw3vmx 139 20 histone histone NN cord-273505-pcsw3vmx 139 21 H3 H3 NNP cord-273505-pcsw3vmx 139 22 ) ) -RRB- cord-273505-pcsw3vmx 139 23 are be VBP cord-273505-pcsw3vmx 139 24 detected detect VBN cord-273505-pcsw3vmx 139 25 in in IN cord-273505-pcsw3vmx 139 26 severe severe JJ cord-273505-pcsw3vmx 139 27 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 139 28 patients patient NNS cord-273505-pcsw3vmx 139 29 and and CC cord-273505-pcsw3vmx 139 30 may may MD cord-273505-pcsw3vmx 139 31 contribute contribute VB cord-273505-pcsw3vmx 139 32 to to IN cord-273505-pcsw3vmx 139 33 cytokine cytokine JJ cord-273505-pcsw3vmx 139 34 storm storm NN cord-273505-pcsw3vmx 139 35 and and CC cord-273505-pcsw3vmx 139 36 respiratory respiratory JJ cord-273505-pcsw3vmx 139 37 failure failure NN cord-273505-pcsw3vmx 139 38 ( ( -LRB- cord-273505-pcsw3vmx 139 39 125 125 CD cord-273505-pcsw3vmx 139 40 ) ) -RRB- cord-273505-pcsw3vmx 139 41 . . . cord-273505-pcsw3vmx 140 1 Both both DT cord-273505-pcsw3vmx 140 2 Fc Fc NNP cord-273505-pcsw3vmx 140 3 and and CC cord-273505-pcsw3vmx 140 4 F(ab f(ab NN cord-273505-pcsw3vmx 140 5 ) ) -RRB- cord-273505-pcsw3vmx 141 1 ′ ′ CD cord-273505-pcsw3vmx 141 2 2 2 CD cord-273505-pcsw3vmx 141 3 fragments fragment NNS cord-273505-pcsw3vmx 141 4 account account VBP cord-273505-pcsw3vmx 141 5 for for IN cord-273505-pcsw3vmx 141 6 the the DT cord-273505-pcsw3vmx 141 7 antiinflammatory antiinflammatory JJ cord-273505-pcsw3vmx 141 8 activity activity NN cord-273505-pcsw3vmx 141 9 on on IN cord-273505-pcsw3vmx 141 10 neutrophils neutrophil NNS cord-273505-pcsw3vmx 141 11 . . . cord-273505-pcsw3vmx 142 1 In in IN cord-273505-pcsw3vmx 142 2 patients patient NNS cord-273505-pcsw3vmx 142 3 with with IN cord-273505-pcsw3vmx 142 4 Kawasaki Kawasaki NNP cord-273505-pcsw3vmx 142 5 disease disease NN cord-273505-pcsw3vmx 142 6 , , , cord-273505-pcsw3vmx 142 7 IVIg ivig JJ cord-273505-pcsw3vmx 142 8 therapy therapy NN cord-273505-pcsw3vmx 142 9 reduces reduce VBZ cord-273505-pcsw3vmx 142 10 the the DT cord-273505-pcsw3vmx 142 11 activation activation NN cord-273505-pcsw3vmx 142 12 and and CC cord-273505-pcsw3vmx 142 13 nitric nitric NN cord-273505-pcsw3vmx 142 14 oxide oxide NN cord-273505-pcsw3vmx 142 15 production production NN cord-273505-pcsw3vmx 142 16 of of IN cord-273505-pcsw3vmx 142 17 neutrophils neutrophil NNS cord-273505-pcsw3vmx 142 18 ( ( -LRB- cord-273505-pcsw3vmx 142 19 126 126 CD cord-273505-pcsw3vmx 142 20 ) ) -RRB- cord-273505-pcsw3vmx 142 21 . . . cord-273505-pcsw3vmx 143 1 In in IN cord-273505-pcsw3vmx 143 2 vivo vivo NNP cord-273505-pcsw3vmx 143 3 studies study NNS cord-273505-pcsw3vmx 143 4 revealed reveal VBD cord-273505-pcsw3vmx 143 5 that that IN cord-273505-pcsw3vmx 143 6 IVIg IVIg NNP cord-273505-pcsw3vmx 143 7 inhibits inhibit VBZ cord-273505-pcsw3vmx 143 8 neutrophil neutrophil NN cord-273505-pcsw3vmx 143 9 recruitment recruitment NN cord-273505-pcsw3vmx 143 10 and and CC cord-273505-pcsw3vmx 143 11 activation activation NN cord-273505-pcsw3vmx 143 12 through through IN cord-273505-pcsw3vmx 143 13 the the DT cord-273505-pcsw3vmx 143 14 activation activation NN cord-273505-pcsw3vmx 143 15 of of IN cord-273505-pcsw3vmx 143 16 SHP-1 SHP-1 NNP cord-273505-pcsw3vmx 143 17 via via IN cord-273505-pcsw3vmx 143 18 FcγRIII fcγriii NN cord-273505-pcsw3vmx 143 19 - - HYPH cord-273505-pcsw3vmx 143 20 mediated mediate VBN cord-273505-pcsw3vmx 143 21 mechanisms mechanism NNS cord-273505-pcsw3vmx 143 22 ( ( -LRB- cord-273505-pcsw3vmx 143 23 127 127 CD cord-273505-pcsw3vmx 143 24 ) ) -RRB- cord-273505-pcsw3vmx 143 25 . . . cord-273505-pcsw3vmx 144 1 Furthermore furthermore RB cord-273505-pcsw3vmx 144 2 , , , cord-273505-pcsw3vmx 144 3 IVIg IVIg NNP cord-273505-pcsw3vmx 144 4 contains contain VBZ cord-273505-pcsw3vmx 144 5 anti anti JJ cord-273505-pcsw3vmx 144 6 - - JJ cord-273505-pcsw3vmx 144 7 Siglec Siglec NNP cord-273505-pcsw3vmx 144 8 autoantibodies autoantibody NNS cord-273505-pcsw3vmx 144 9 that that WDT cord-273505-pcsw3vmx 144 10 can can MD cord-273505-pcsw3vmx 144 11 regulate regulate VB cord-273505-pcsw3vmx 144 12 neutrophil neutrophil NN cord-273505-pcsw3vmx 144 13 apoptosis apoptosis NN cord-273505-pcsw3vmx 144 14 in in IN cord-273505-pcsw3vmx 144 15 a a DT cord-273505-pcsw3vmx 144 16 dose dose NN cord-273505-pcsw3vmx 144 17 - - HYPH cord-273505-pcsw3vmx 144 18 dependent dependent JJ cord-273505-pcsw3vmx 144 19 cytotoxic cytotoxic JJ cord-273505-pcsw3vmx 144 20 manner manner NN cord-273505-pcsw3vmx 144 21 via via IN cord-273505-pcsw3vmx 144 22 F(ab f(ab NN cord-273505-pcsw3vmx 144 23 ) ) -RRB- cord-273505-pcsw3vmx 144 24 ′ ′ CD cord-273505-pcsw3vmx 144 25 2 2 CD cord-273505-pcsw3vmx 144 26 -mediated -mediated JJ cord-273505-pcsw3vmx 144 27 mechanisms mechanism NNS cord-273505-pcsw3vmx 144 28 ( ( -LRB- cord-273505-pcsw3vmx 144 29 33 33 CD cord-273505-pcsw3vmx 144 30 , , , cord-273505-pcsw3vmx 144 31 128 128 CD cord-273505-pcsw3vmx 144 32 , , , cord-273505-pcsw3vmx 144 33 129 129 CD cord-273505-pcsw3vmx 144 34 ) ) -RRB- cord-273505-pcsw3vmx 144 35 . . . cord-273505-pcsw3vmx 145 1 Interestingly interestingly RB cord-273505-pcsw3vmx 145 2 , , , cord-273505-pcsw3vmx 145 3 high high JJ cord-273505-pcsw3vmx 145 4 - - HYPH cord-273505-pcsw3vmx 145 5 dose dose NN cord-273505-pcsw3vmx 145 6 sulfo sulfo NN cord-273505-pcsw3vmx 145 7 - - HYPH cord-273505-pcsw3vmx 145 8 IVIg ivig JJ cord-273505-pcsw3vmx 145 9 preparations preparation NNS cord-273505-pcsw3vmx 145 10 significantly significantly RB cord-273505-pcsw3vmx 145 11 reduce reduce VBP cord-273505-pcsw3vmx 145 12 NET net NN cord-273505-pcsw3vmx 145 13 formation formation NN cord-273505-pcsw3vmx 145 14 in in IN cord-273505-pcsw3vmx 145 15 vitro vitro FW cord-273505-pcsw3vmx 145 16 as as RB cord-273505-pcsw3vmx 145 17 well well RB cord-273505-pcsw3vmx 145 18 as as IN cord-273505-pcsw3vmx 145 19 in in IN cord-273505-pcsw3vmx 145 20 rat rat NN cord-273505-pcsw3vmx 145 21 models model NNS cord-273505-pcsw3vmx 145 22 ( ( -LRB- cord-273505-pcsw3vmx 145 23 130 130 CD cord-273505-pcsw3vmx 145 24 ) ) -RRB- cord-273505-pcsw3vmx 145 25 . . . cord-273505-pcsw3vmx 146 1 Natural natural JJ cord-273505-pcsw3vmx 146 2 killer killer NN cord-273505-pcsw3vmx 146 3 ( ( -LRB- cord-273505-pcsw3vmx 146 4 NK NK NNP cord-273505-pcsw3vmx 146 5 ) ) -RRB- cord-273505-pcsw3vmx 146 6 cells cell NNS cord-273505-pcsw3vmx 146 7 are be VBP cord-273505-pcsw3vmx 146 8 innate innate JJ cord-273505-pcsw3vmx 146 9 lymphocytes lymphocyte NNS cord-273505-pcsw3vmx 146 10 that that WDT cord-273505-pcsw3vmx 146 11 play play VBP cord-273505-pcsw3vmx 146 12 an an DT cord-273505-pcsw3vmx 146 13 essential essential JJ cord-273505-pcsw3vmx 146 14 role role NN cord-273505-pcsw3vmx 146 15 in in IN cord-273505-pcsw3vmx 146 16 the the DT cord-273505-pcsw3vmx 146 17 control control NN cord-273505-pcsw3vmx 146 18 of of IN cord-273505-pcsw3vmx 146 19 respiratory respiratory JJ cord-273505-pcsw3vmx 146 20 viral viral JJ cord-273505-pcsw3vmx 146 21 infections infection NNS cord-273505-pcsw3vmx 146 22 . . . cord-273505-pcsw3vmx 147 1 Within within IN cord-273505-pcsw3vmx 147 2 days day NNS cord-273505-pcsw3vmx 147 3 after after IN cord-273505-pcsw3vmx 147 4 a a DT cord-273505-pcsw3vmx 147 5 respiratory respiratory JJ cord-273505-pcsw3vmx 147 6 viral viral JJ cord-273505-pcsw3vmx 147 7 infection infection NN cord-273505-pcsw3vmx 147 8 , , , cord-273505-pcsw3vmx 147 9 NK NK NNP cord-273505-pcsw3vmx 147 10 cells cell NNS cord-273505-pcsw3vmx 147 11 are be VBP cord-273505-pcsw3vmx 147 12 activated activate VBN cord-273505-pcsw3vmx 147 13 , , , cord-273505-pcsw3vmx 147 14 recruited recruit VBN cord-273505-pcsw3vmx 147 15 to to IN cord-273505-pcsw3vmx 147 16 the the DT cord-273505-pcsw3vmx 147 17 lung lung NN cord-273505-pcsw3vmx 147 18 , , , cord-273505-pcsw3vmx 147 19 and and CC cord-273505-pcsw3vmx 147 20 act act VB cord-273505-pcsw3vmx 147 21 as as IN cord-273505-pcsw3vmx 147 22 effector effector NN cord-273505-pcsw3vmx 147 23 cells cell NNS cord-273505-pcsw3vmx 147 24 in in IN cord-273505-pcsw3vmx 147 25 a a DT cord-273505-pcsw3vmx 147 26 classical classical JJ cord-273505-pcsw3vmx 147 27 FcγR fcγr NN cord-273505-pcsw3vmx 147 28 - - HYPH cord-273505-pcsw3vmx 147 29 mediated mediate VBN cord-273505-pcsw3vmx 147 30 function function NN cord-273505-pcsw3vmx 147 31 , , , cord-273505-pcsw3vmx 147 32 namely namely RB cord-273505-pcsw3vmx 147 33 antibody antibody NN cord-273505-pcsw3vmx 147 34 - - HYPH cord-273505-pcsw3vmx 147 35 dependent dependent JJ cord-273505-pcsw3vmx 147 36 cytotoxicity cytotoxicity NN cord-273505-pcsw3vmx 147 37 ( ( -LRB- cord-273505-pcsw3vmx 147 38 ADCC ADCC NNP cord-273505-pcsw3vmx 147 39 ) ) -RRB- cord-273505-pcsw3vmx 147 40 . . . cord-273505-pcsw3vmx 148 1 However however RB cord-273505-pcsw3vmx 148 2 , , , cord-273505-pcsw3vmx 148 3 a a DT cord-273505-pcsw3vmx 148 4 dysfunction dysfunction NN cord-273505-pcsw3vmx 148 5 of of IN cord-273505-pcsw3vmx 148 6 NK NK NNP cord-273505-pcsw3vmx 148 7 cells cell NNS cord-273505-pcsw3vmx 148 8 may may MD cord-273505-pcsw3vmx 148 9 also also RB cord-273505-pcsw3vmx 148 10 be be VB cord-273505-pcsw3vmx 148 11 responsible responsible JJ cord-273505-pcsw3vmx 148 12 for for IN cord-273505-pcsw3vmx 148 13 immunopathogenesis immunopathogenesis NN cord-273505-pcsw3vmx 148 14 during during IN cord-273505-pcsw3vmx 148 15 infection infection NN cord-273505-pcsw3vmx 148 16 . . . cord-273505-pcsw3vmx 149 1 Increased increase VBN cord-273505-pcsw3vmx 149 2 inhibitory inhibitory JJ cord-273505-pcsw3vmx 149 3 receptor receptor NN cord-273505-pcsw3vmx 149 4 NKG2A nkg2a CD cord-273505-pcsw3vmx 149 5 expression expression NN cord-273505-pcsw3vmx 149 6 on on IN cord-273505-pcsw3vmx 149 7 NK NK NNP cord-273505-pcsw3vmx 149 8 cells cell NNS cord-273505-pcsw3vmx 149 9 and and CC cord-273505-pcsw3vmx 149 10 reduced reduce VBN cord-273505-pcsw3vmx 149 11 production production NN cord-273505-pcsw3vmx 149 12 of of IN cord-273505-pcsw3vmx 149 13 CD107a CD107a NNP cord-273505-pcsw3vmx 149 14 , , , cord-273505-pcsw3vmx 149 15 IFN IFN NNP cord-273505-pcsw3vmx 149 16 - - HYPH cord-273505-pcsw3vmx 149 17 γ γ NNP cord-273505-pcsw3vmx 149 18 , , , cord-273505-pcsw3vmx 149 19 IL-2 IL-2 NNP cord-273505-pcsw3vmx 149 20 , , , cord-273505-pcsw3vmx 149 21 and and CC cord-273505-pcsw3vmx 149 22 TNF TNF NNP cord-273505-pcsw3vmx 149 23 - - HYPH cord-273505-pcsw3vmx 149 24 α α NNP cord-273505-pcsw3vmx 149 25 , , , cord-273505-pcsw3vmx 149 26 indicate indicate VBP cord-273505-pcsw3vmx 149 27 a a DT cord-273505-pcsw3vmx 149 28 functional functional JJ cord-273505-pcsw3vmx 149 29 exhaustion exhaustion NN cord-273505-pcsw3vmx 149 30 of of IN cord-273505-pcsw3vmx 149 31 NK NK NNP cord-273505-pcsw3vmx 149 32 cells cell NNS cord-273505-pcsw3vmx 149 33 during during IN cord-273505-pcsw3vmx 149 34 SARS SARS NNP cord-273505-pcsw3vmx 149 35 - - HYPH cord-273505-pcsw3vmx 149 36 CoV-2 CoV-2 NNP cord-273505-pcsw3vmx 149 37 infection infection NN cord-273505-pcsw3vmx 149 38 , , , cord-273505-pcsw3vmx 149 39 similar similar JJ cord-273505-pcsw3vmx 149 40 to to IN cord-273505-pcsw3vmx 149 41 that that DT cord-273505-pcsw3vmx 149 42 observed observe VBN cord-273505-pcsw3vmx 149 43 in in IN cord-273505-pcsw3vmx 149 44 SARS SARS NNP cord-273505-pcsw3vmx 149 45 ( ( -LRB- cord-273505-pcsw3vmx 149 46 131 131 CD cord-273505-pcsw3vmx 149 47 ) ) -RRB- cord-273505-pcsw3vmx 149 48 . . . cord-273505-pcsw3vmx 150 1 In in IN cord-273505-pcsw3vmx 150 2 patients patient NNS cord-273505-pcsw3vmx 150 3 with with IN cord-273505-pcsw3vmx 150 4 severe severe JJ cord-273505-pcsw3vmx 150 5 SARS SARS NNP cord-273505-pcsw3vmx 150 6 , , , cord-273505-pcsw3vmx 150 7 the the DT cord-273505-pcsw3vmx 150 8 number number NN cord-273505-pcsw3vmx 150 9 of of IN cord-273505-pcsw3vmx 150 10 NK NK NNP cord-273505-pcsw3vmx 150 11 cells cell NNS cord-273505-pcsw3vmx 150 12 and and CC cord-273505-pcsw3vmx 150 13 levels level NNS cord-273505-pcsw3vmx 150 14 of of IN cord-273505-pcsw3vmx 150 15 the the DT cord-273505-pcsw3vmx 150 16 functional functional JJ cord-273505-pcsw3vmx 150 17 NK nk NN cord-273505-pcsw3vmx 150 18 - - HYPH cord-273505-pcsw3vmx 150 19 marker marker NN cord-273505-pcsw3vmx 150 20 KIR2DL3 KIR2DL3 NNP cord-273505-pcsw3vmx 150 21 were be VBD cord-273505-pcsw3vmx 150 22 significantly significantly RB cord-273505-pcsw3vmx 150 23 lower low JJR cord-273505-pcsw3vmx 150 24 than than IN cord-273505-pcsw3vmx 150 25 in in IN cord-273505-pcsw3vmx 150 26 patients patient NNS cord-273505-pcsw3vmx 150 27 with with IN cord-273505-pcsw3vmx 150 28 mild mild JJ cord-273505-pcsw3vmx 150 29 SARS SARS NNP cord-273505-pcsw3vmx 150 30 , , , cord-273505-pcsw3vmx 150 31 mycoplasma mycoplasma NN cord-273505-pcsw3vmx 150 32 pneumonia pneumonia NN cord-273505-pcsw3vmx 150 33 , , , cord-273505-pcsw3vmx 150 34 or or CC cord-273505-pcsw3vmx 150 35 healthy healthy JJ cord-273505-pcsw3vmx 150 36 controls control NNS cord-273505-pcsw3vmx 150 37 , , , cord-273505-pcsw3vmx 150 38 manifesting manifest VBG cord-273505-pcsw3vmx 150 39 a a DT cord-273505-pcsw3vmx 150 40 correlation correlation NN cord-273505-pcsw3vmx 150 41 between between IN cord-273505-pcsw3vmx 150 42 the the DT cord-273505-pcsw3vmx 150 43 severity severity NN cord-273505-pcsw3vmx 150 44 of of IN cord-273505-pcsw3vmx 150 45 SARS SARS NNP cord-273505-pcsw3vmx 150 46 and and CC cord-273505-pcsw3vmx 150 47 the the DT cord-273505-pcsw3vmx 150 48 number number NN cord-273505-pcsw3vmx 150 49 and and CC cord-273505-pcsw3vmx 150 50 function function NN cord-273505-pcsw3vmx 150 51 of of IN cord-273505-pcsw3vmx 150 52 NK NK NNP cord-273505-pcsw3vmx 150 53 cells cell NNS cord-273505-pcsw3vmx 150 54 ( ( -LRB- cord-273505-pcsw3vmx 150 55 132 132 CD cord-273505-pcsw3vmx 150 56 ) ) -RRB- cord-273505-pcsw3vmx 150 57 . . . cord-273505-pcsw3vmx 151 1 During during IN cord-273505-pcsw3vmx 151 2 influenza influenza NN cord-273505-pcsw3vmx 151 3 virus virus NN cord-273505-pcsw3vmx 151 4 and and CC cord-273505-pcsw3vmx 151 5 RSV RSV NNP cord-273505-pcsw3vmx 151 6 infection infection NN cord-273505-pcsw3vmx 151 7 , , , cord-273505-pcsw3vmx 151 8 virus virus NN cord-273505-pcsw3vmx 151 9 - - HYPH cord-273505-pcsw3vmx 151 10 induced induce VBN cord-273505-pcsw3vmx 151 11 apoptosis apoptosis NN cord-273505-pcsw3vmx 151 12 or or CC cord-273505-pcsw3vmx 151 13 modulation modulation NN cord-273505-pcsw3vmx 151 14 of of IN cord-273505-pcsw3vmx 151 15 NK NK NNP cord-273505-pcsw3vmx 151 16 cell cell NN cord-273505-pcsw3vmx 151 17 cytotoxicity cytotoxicity NN cord-273505-pcsw3vmx 151 18 has have VBZ cord-273505-pcsw3vmx 151 19 also also RB cord-273505-pcsw3vmx 151 20 been be VBN cord-273505-pcsw3vmx 151 21 proposed propose VBN cord-273505-pcsw3vmx 151 22 to to TO cord-273505-pcsw3vmx 151 23 serve serve VB cord-273505-pcsw3vmx 151 24 as as IN cord-273505-pcsw3vmx 151 25 a a DT cord-273505-pcsw3vmx 151 26 viral viral JJ cord-273505-pcsw3vmx 151 27 evasion evasion NN cord-273505-pcsw3vmx 151 28 strategy strategy NN cord-273505-pcsw3vmx 151 29 , , , cord-273505-pcsw3vmx 151 30 and and CC cord-273505-pcsw3vmx 151 31 eventually eventually RB cord-273505-pcsw3vmx 151 32 skew skew VB cord-273505-pcsw3vmx 151 33 the the DT cord-273505-pcsw3vmx 151 34 inflammatory inflammatory JJ cord-273505-pcsw3vmx 151 35 profile profile NN cord-273505-pcsw3vmx 151 36 of of IN cord-273505-pcsw3vmx 151 37 the the DT cord-273505-pcsw3vmx 151 38 immune immune JJ cord-273505-pcsw3vmx 151 39 system system NN cord-273505-pcsw3vmx 151 40 ( ( -LRB- cord-273505-pcsw3vmx 151 41 133 133 CD cord-273505-pcsw3vmx 151 42 , , , cord-273505-pcsw3vmx 151 43 134 134 CD cord-273505-pcsw3vmx 151 44 ) ) -RRB- cord-273505-pcsw3vmx 151 45 . . . cord-273505-pcsw3vmx 152 1 After after IN cord-273505-pcsw3vmx 152 2 high high JJ cord-273505-pcsw3vmx 152 3 - - HYPH cord-273505-pcsw3vmx 152 4 dose dose NN cord-273505-pcsw3vmx 152 5 IVIg ivig NN cord-273505-pcsw3vmx 152 6 therapy therapy NN cord-273505-pcsw3vmx 152 7 , , , cord-273505-pcsw3vmx 152 8 a a DT cord-273505-pcsw3vmx 152 9 reduction reduction NN cord-273505-pcsw3vmx 152 10 in in IN cord-273505-pcsw3vmx 152 11 number number NN cord-273505-pcsw3vmx 152 12 and and CC cord-273505-pcsw3vmx 152 13 cytotoxic cytotoxic JJ cord-273505-pcsw3vmx 152 14 activity activity NN cord-273505-pcsw3vmx 152 15 of of IN cord-273505-pcsw3vmx 152 16 NK NK NNP cord-273505-pcsw3vmx 152 17 cells cell NNS cord-273505-pcsw3vmx 152 18 is be VBZ cord-273505-pcsw3vmx 152 19 observed observe VBN cord-273505-pcsw3vmx 152 20 in in IN cord-273505-pcsw3vmx 152 21 patients patient NNS cord-273505-pcsw3vmx 152 22 with with IN cord-273505-pcsw3vmx 152 23 autoimmune autoimmune JJ cord-273505-pcsw3vmx 152 24 diseases disease NNS cord-273505-pcsw3vmx 152 25 ( ( -LRB- cord-273505-pcsw3vmx 152 26 135 135 CD cord-273505-pcsw3vmx 152 27 ) ) -RRB- cord-273505-pcsw3vmx 152 28 ( ( -LRB- cord-273505-pcsw3vmx 152 29 136 136 CD cord-273505-pcsw3vmx 152 30 ) ) -RRB- cord-273505-pcsw3vmx 152 31 ( ( -LRB- cord-273505-pcsw3vmx 152 32 137 137 CD cord-273505-pcsw3vmx 152 33 ) ) -RRB- cord-273505-pcsw3vmx 152 34 . . . cord-273505-pcsw3vmx 153 1 The the DT cord-273505-pcsw3vmx 153 2 dose dose NN cord-273505-pcsw3vmx 153 3 - - HYPH cord-273505-pcsw3vmx 153 4 dependent dependent JJ cord-273505-pcsw3vmx 153 5 FcγRIII fcγriii NN cord-273505-pcsw3vmx 153 6 blockade blockade NN cord-273505-pcsw3vmx 153 7 and and CC cord-273505-pcsw3vmx 153 8 circulating circulate VBG cord-273505-pcsw3vmx 153 9 NK NK NNP cord-273505-pcsw3vmx 153 10 cells cell NNS cord-273505-pcsw3vmx 153 11 decline decline NN cord-273505-pcsw3vmx 153 12 occurred occur VBD cord-273505-pcsw3vmx 153 13 following follow VBG cord-273505-pcsw3vmx 153 14 IVIg ivig JJ cord-273505-pcsw3vmx 153 15 treatment treatment NN cord-273505-pcsw3vmx 153 16 , , , cord-273505-pcsw3vmx 153 17 suggesting suggest VBG cord-273505-pcsw3vmx 153 18 that that IN cord-273505-pcsw3vmx 153 19 inhibition inhibition NN cord-273505-pcsw3vmx 153 20 of of IN cord-273505-pcsw3vmx 153 21 NK NK NNP cord-273505-pcsw3vmx 153 22 cells cell NNS cord-273505-pcsw3vmx 153 23 by by IN cord-273505-pcsw3vmx 153 24 highdose highdose NN cord-273505-pcsw3vmx 153 25 IVIg IVIg NNP cord-273505-pcsw3vmx 153 26 is be VBZ cord-273505-pcsw3vmx 153 27 associated associate VBN cord-273505-pcsw3vmx 153 28 with with IN cord-273505-pcsw3vmx 153 29 the the DT cord-273505-pcsw3vmx 153 30 saturation saturation NN cord-273505-pcsw3vmx 153 31 of of IN cord-273505-pcsw3vmx 153 32 activating activate VBG cord-273505-pcsw3vmx 153 33 FcγRs FcγRs NNP cord-273505-pcsw3vmx 153 34 ( ( -LRB- cord-273505-pcsw3vmx 153 35 135 135 CD cord-273505-pcsw3vmx 153 36 ) ) -RRB- cord-273505-pcsw3vmx 153 37 . . . cord-273505-pcsw3vmx 154 1 The the DT cord-273505-pcsw3vmx 154 2 inhibitory inhibitory JJ cord-273505-pcsw3vmx 154 3 effects effect NNS cord-273505-pcsw3vmx 154 4 of of IN cord-273505-pcsw3vmx 154 5 IVIg ivig JJ cord-273505-pcsw3vmx 154 6 therapy therapy NN cord-273505-pcsw3vmx 154 7 on on IN cord-273505-pcsw3vmx 154 8 NK NK NNP cord-273505-pcsw3vmx 154 9 cells cell NNS cord-273505-pcsw3vmx 154 10 may may MD cord-273505-pcsw3vmx 154 11 , , , cord-273505-pcsw3vmx 154 12 however however RB cord-273505-pcsw3vmx 154 13 , , , cord-273505-pcsw3vmx 154 14 not not RB cord-273505-pcsw3vmx 154 15 impair impair VB cord-273505-pcsw3vmx 154 16 its -PRON- PRP$ cord-273505-pcsw3vmx 154 17 functions function NNS cord-273505-pcsw3vmx 154 18 for for IN cord-273505-pcsw3vmx 154 19 controlling control VBG cord-273505-pcsw3vmx 154 20 viral viral JJ cord-273505-pcsw3vmx 154 21 infections infection NNS cord-273505-pcsw3vmx 154 22 and and CC cord-273505-pcsw3vmx 154 23 malignancies malignancy NNS cord-273505-pcsw3vmx 154 24 ( ( -LRB- cord-273505-pcsw3vmx 154 25 138 138 CD cord-273505-pcsw3vmx 154 26 ) ) -RRB- cord-273505-pcsw3vmx 154 27 . . . cord-273505-pcsw3vmx 155 1 Cytokines cytokine NNS cord-273505-pcsw3vmx 155 2 secreted secrete VBN cord-273505-pcsw3vmx 155 3 by by IN cord-273505-pcsw3vmx 155 4 different different JJ cord-273505-pcsw3vmx 155 5 subclasses subclass NNS cord-273505-pcsw3vmx 155 6 of of IN cord-273505-pcsw3vmx 155 7 CD4 CD4 NNP cord-273505-pcsw3vmx 155 8 + + CC cord-273505-pcsw3vmx 155 9 T T NNP cord-273505-pcsw3vmx 155 10 cells cell NNS cord-273505-pcsw3vmx 155 11 trigger trigger VBP cord-273505-pcsw3vmx 155 12 the the DT cord-273505-pcsw3vmx 155 13 immune immune JJ cord-273505-pcsw3vmx 155 14 response response NN cord-273505-pcsw3vmx 155 15 to to IN cord-273505-pcsw3vmx 155 16 pathogens pathogen NNS cord-273505-pcsw3vmx 155 17 and and CC cord-273505-pcsw3vmx 155 18 maintain maintain VB cord-273505-pcsw3vmx 155 19 immune immune JJ cord-273505-pcsw3vmx 155 20 homeostasis homeostasis NN cord-273505-pcsw3vmx 155 21 . . . cord-273505-pcsw3vmx 156 1 However however RB cord-273505-pcsw3vmx 156 2 , , , cord-273505-pcsw3vmx 156 3 an an DT cord-273505-pcsw3vmx 156 4 imbalance imbalance NN cord-273505-pcsw3vmx 156 5 of of IN cord-273505-pcsw3vmx 156 6 Th1 th1 NN cord-273505-pcsw3vmx 156 7 , , , cord-273505-pcsw3vmx 156 8 Th2 Th2 NNP cord-273505-pcsw3vmx 156 9 , , , cord-273505-pcsw3vmx 156 10 Th17 Th17 NNP cord-273505-pcsw3vmx 156 11 , , , cord-273505-pcsw3vmx 156 12 and and CC cord-273505-pcsw3vmx 156 13 Treg Treg NNP cord-273505-pcsw3vmx 156 14 subclasses subclass NNS cord-273505-pcsw3vmx 156 15 is be VBZ cord-273505-pcsw3vmx 156 16 associated associate VBN cord-273505-pcsw3vmx 156 17 with with IN cord-273505-pcsw3vmx 156 18 dysfunctional dysfunctional JJ cord-273505-pcsw3vmx 156 19 cytokine cytokine JJ cord-273505-pcsw3vmx 156 20 responses response NNS cord-273505-pcsw3vmx 156 21 during during IN cord-273505-pcsw3vmx 156 22 severe severe JJ cord-273505-pcsw3vmx 156 23 viral viral JJ cord-273505-pcsw3vmx 156 24 infections infection NNS cord-273505-pcsw3vmx 156 25 . . . cord-273505-pcsw3vmx 157 1 The the DT cord-273505-pcsw3vmx 157 2 profiles profile NNS cord-273505-pcsw3vmx 157 3 of of IN cord-273505-pcsw3vmx 157 4 serum serum NN cord-273505-pcsw3vmx 157 5 cytokines cytokine NNS cord-273505-pcsw3vmx 157 6 revealed reveal VBD cord-273505-pcsw3vmx 157 7 an an DT cord-273505-pcsw3vmx 157 8 increased increase VBN cord-273505-pcsw3vmx 157 9 concentration concentration NN cord-273505-pcsw3vmx 157 10 of of IN cord-273505-pcsw3vmx 157 11 Th17 Th17 NNP cord-273505-pcsw3vmx 157 12 cells cell NNS cord-273505-pcsw3vmx 157 13 in in IN cord-273505-pcsw3vmx 157 14 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 157 15 patients patient NNS cord-273505-pcsw3vmx 157 16 ( ( -LRB- cord-273505-pcsw3vmx 157 17 139 139 CD cord-273505-pcsw3vmx 157 18 , , , cord-273505-pcsw3vmx 157 19 140 140 CD cord-273505-pcsw3vmx 157 20 ) ) -RRB- cord-273505-pcsw3vmx 157 21 . . . cord-273505-pcsw3vmx 158 1 In in IN cord-273505-pcsw3vmx 158 2 severe severe JJ cord-273505-pcsw3vmx 158 3 SARS SARS NNP cord-273505-pcsw3vmx 158 4 patients patient NNS cord-273505-pcsw3vmx 158 5 , , , cord-273505-pcsw3vmx 158 6 the the DT cord-273505-pcsw3vmx 158 7 activation activation NN cord-273505-pcsw3vmx 158 8 of of IN cord-273505-pcsw3vmx 158 9 Th1-related Th1-related NNP cord-273505-pcsw3vmx 158 10 cytokines cytokine NNS cord-273505-pcsw3vmx 158 11 and and CC cord-273505-pcsw3vmx 158 12 chemokines chemokine NNS cord-273505-pcsw3vmx 158 13 ( ( -LRB- cord-273505-pcsw3vmx 158 14 e.g. e.g. RB cord-273505-pcsw3vmx 158 15 , , , cord-273505-pcsw3vmx 158 16 IL-1 IL-1 NNP cord-273505-pcsw3vmx 158 17 , , , cord-273505-pcsw3vmx 158 18 IL-6 IL-6 NNP cord-273505-pcsw3vmx 158 19 , , , cord-273505-pcsw3vmx 158 20 IL-12 IL-12 NNP cord-273505-pcsw3vmx 158 21 ) ) -RRB- cord-273505-pcsw3vmx 158 22 was be VBD cord-273505-pcsw3vmx 158 23 involved involve VBN cord-273505-pcsw3vmx 158 24 in in IN cord-273505-pcsw3vmx 158 25 hyperinflammatory hyperinflammatory JJ cord-273505-pcsw3vmx 158 26 conditions condition NNS cord-273505-pcsw3vmx 158 27 ( ( -LRB- cord-273505-pcsw3vmx 158 28 141 141 CD cord-273505-pcsw3vmx 158 29 ) ) -RRB- cord-273505-pcsw3vmx 158 30 . . . cord-273505-pcsw3vmx 159 1 Furthermore furthermore RB cord-273505-pcsw3vmx 159 2 , , , cord-273505-pcsw3vmx 159 3 in in IN cord-273505-pcsw3vmx 159 4 MERS MERS NNP cord-273505-pcsw3vmx 159 5 patients patient NNS cord-273505-pcsw3vmx 159 6 , , , cord-273505-pcsw3vmx 159 7 the the DT cord-273505-pcsw3vmx 159 8 significantly significantly RB cord-273505-pcsw3vmx 159 9 increased increase VBN cord-273505-pcsw3vmx 159 10 release release NN cord-273505-pcsw3vmx 159 11 of of IN cord-273505-pcsw3vmx 159 12 pro pro JJ cord-273505-pcsw3vmx 159 13 - - JJ cord-273505-pcsw3vmx 159 14 inflammatory inflammatory JJ cord-273505-pcsw3vmx 159 15 cytokines cytokine NNS cord-273505-pcsw3vmx 159 16 from from IN cord-273505-pcsw3vmx 159 17 Th1 th1 NN cord-273505-pcsw3vmx 159 18 and and CC cord-273505-pcsw3vmx 159 19 Th17 Th17 NNP cord-273505-pcsw3vmx 159 20 during during IN cord-273505-pcsw3vmx 159 21 the the DT cord-273505-pcsw3vmx 159 22 acute acute JJ cord-273505-pcsw3vmx 159 23 phase phase NN cord-273505-pcsw3vmx 159 24 was be VBD cord-273505-pcsw3vmx 159 25 considered consider VBN cord-273505-pcsw3vmx 159 26 to to TO cord-273505-pcsw3vmx 159 27 be be VB cord-273505-pcsw3vmx 159 28 at at IN cord-273505-pcsw3vmx 159 29 least least JJS cord-273505-pcsw3vmx 159 30 partly partly RB cord-273505-pcsw3vmx 159 31 responsible responsible JJ cord-273505-pcsw3vmx 159 32 for for IN cord-273505-pcsw3vmx 159 33 the the DT cord-273505-pcsw3vmx 159 34 immunopathology immunopathology NN cord-273505-pcsw3vmx 159 35 ( ( -LRB- cord-273505-pcsw3vmx 159 36 142 142 CD cord-273505-pcsw3vmx 159 37 ) ) -RRB- cord-273505-pcsw3vmx 159 38 . . . cord-273505-pcsw3vmx 160 1 Early early JJ cord-273505-pcsw3vmx 160 2 abundant abundant JJ cord-273505-pcsw3vmx 160 3 secretion secretion NN cord-273505-pcsw3vmx 160 4 of of IN cord-273505-pcsw3vmx 160 5 Th1-and th1-and NN cord-273505-pcsw3vmx 160 6 Th17-related Th17-related NNP cord-273505-pcsw3vmx 160 7 cytokines cytokine NNS cord-273505-pcsw3vmx 160 8 ( ( -LRB- cord-273505-pcsw3vmx 160 9 e.g. e.g. RB cord-273505-pcsw3vmx 160 10 , , , cord-273505-pcsw3vmx 160 11 IL-6 IL-6 NNP cord-273505-pcsw3vmx 160 12 and and CC cord-273505-pcsw3vmx 160 13 IL-17 IL-17 NNP cord-273505-pcsw3vmx 160 14 ) ) -RRB- cord-273505-pcsw3vmx 160 15 has have VBZ cord-273505-pcsw3vmx 160 16 furthermore furthermore RB cord-273505-pcsw3vmx 160 17 been be VBN cord-273505-pcsw3vmx 160 18 associated associate VBN cord-273505-pcsw3vmx 160 19 with with IN cord-273505-pcsw3vmx 160 20 complicated complicated JJ cord-273505-pcsw3vmx 160 21 infections infection NNS cord-273505-pcsw3vmx 160 22 and and CC cord-273505-pcsw3vmx 160 23 mortality mortality NN cord-273505-pcsw3vmx 160 24 in in IN cord-273505-pcsw3vmx 160 25 severe severe JJ cord-273505-pcsw3vmx 160 26 influenza influenza NN cord-273505-pcsw3vmx 160 27 patients patient NNS cord-273505-pcsw3vmx 160 28 ( ( -LRB- cord-273505-pcsw3vmx 160 29 143 143 CD cord-273505-pcsw3vmx 160 30 , , , cord-273505-pcsw3vmx 160 31 144 144 CD cord-273505-pcsw3vmx 160 32 ) ) -RRB- cord-273505-pcsw3vmx 160 33 . . . cord-273505-pcsw3vmx 161 1 In in IN cord-273505-pcsw3vmx 161 2 addition addition NN cord-273505-pcsw3vmx 161 3 to to IN cord-273505-pcsw3vmx 161 4 mediating mediate VBG cord-273505-pcsw3vmx 161 5 expansion expansion NN cord-273505-pcsw3vmx 161 6 of of IN cord-273505-pcsw3vmx 161 7 Tregs Tregs NNP cord-273505-pcsw3vmx 161 8 , , , cord-273505-pcsw3vmx 161 9 which which WDT cord-273505-pcsw3vmx 161 10 profoundly profoundly RB cord-273505-pcsw3vmx 161 11 impacts impact VBZ cord-273505-pcsw3vmx 161 12 immune immune JJ cord-273505-pcsw3vmx 161 13 cascades cascade NNS cord-273505-pcsw3vmx 161 14 , , , cord-273505-pcsw3vmx 161 15 high high JJ cord-273505-pcsw3vmx 161 16 - - HYPH cord-273505-pcsw3vmx 161 17 dose dose NN cord-273505-pcsw3vmx 161 18 IVIg ivig NN cord-273505-pcsw3vmx 161 19 has have VBZ cord-273505-pcsw3vmx 161 20 also also RB cord-273505-pcsw3vmx 161 21 been be VBN cord-273505-pcsw3vmx 161 22 shown show VBN cord-273505-pcsw3vmx 161 23 to to TO cord-273505-pcsw3vmx 161 24 inhibit inhibit VB cord-273505-pcsw3vmx 161 25 the the DT cord-273505-pcsw3vmx 161 26 activation activation NN cord-273505-pcsw3vmx 161 27 and and CC cord-273505-pcsw3vmx 161 28 subsequent subsequent JJ cord-273505-pcsw3vmx 161 29 production production NN cord-273505-pcsw3vmx 161 30 of of IN cord-273505-pcsw3vmx 161 31 cytokines cytokine NNS cord-273505-pcsw3vmx 161 32 by by IN cord-273505-pcsw3vmx 161 33 Th1 th1 NN cord-273505-pcsw3vmx 161 34 and and CC cord-273505-pcsw3vmx 161 35 Th17 Th17 NNP cord-273505-pcsw3vmx 161 36 cells cell NNS cord-273505-pcsw3vmx 161 37 in in IN cord-273505-pcsw3vmx 161 38 several several JJ cord-273505-pcsw3vmx 161 39 clinical clinical JJ cord-273505-pcsw3vmx 161 40 studies study NNS cord-273505-pcsw3vmx 161 41 and and CC cord-273505-pcsw3vmx 161 42 in in IN cord-273505-pcsw3vmx 161 43 vitro vitro FW cord-273505-pcsw3vmx 161 44 experiments experiment NNS cord-273505-pcsw3vmx 161 45 ( ( -LRB- cord-273505-pcsw3vmx 161 46 145 145 CD cord-273505-pcsw3vmx 161 47 ) ) -RRB- cord-273505-pcsw3vmx 161 48 ( ( -LRB- cord-273505-pcsw3vmx 161 49 146 146 CD cord-273505-pcsw3vmx 161 50 ) ) -RRB- cord-273505-pcsw3vmx 161 51 ( ( -LRB- cord-273505-pcsw3vmx 161 52 147 147 CD cord-273505-pcsw3vmx 161 53 ) ) -RRB- cord-273505-pcsw3vmx 161 54 ( ( -LRB- cord-273505-pcsw3vmx 161 55 148 148 CD cord-273505-pcsw3vmx 161 56 ) ) -RRB- cord-273505-pcsw3vmx 161 57 ( ( -LRB- cord-273505-pcsw3vmx 161 58 149 149 CD cord-273505-pcsw3vmx 161 59 ) ) -RRB- cord-273505-pcsw3vmx 162 1 ( ( -LRB- cord-273505-pcsw3vmx 162 2 150 150 CD cord-273505-pcsw3vmx 162 3 ) ) -RRB- cord-273505-pcsw3vmx 162 4 ( ( -LRB- cord-273505-pcsw3vmx 162 5 151 151 CD cord-273505-pcsw3vmx 162 6 ) ) -RRB- cord-273505-pcsw3vmx 162 7 ( ( -LRB- cord-273505-pcsw3vmx 162 8 152 152 CD cord-273505-pcsw3vmx 162 9 ) ) -RRB- cord-273505-pcsw3vmx 162 10 ( ( -LRB- cord-273505-pcsw3vmx 162 11 153 153 CD cord-273505-pcsw3vmx 162 12 ) ) -RRB- cord-273505-pcsw3vmx 162 13 ( ( -LRB- cord-273505-pcsw3vmx 162 14 154 154 CD cord-273505-pcsw3vmx 162 15 ) ) -RRB- cord-273505-pcsw3vmx 162 16 ( ( -LRB- cord-273505-pcsw3vmx 162 17 155 155 CD cord-273505-pcsw3vmx 162 18 ) ) -RRB- cord-273505-pcsw3vmx 162 19 ( ( -LRB- cord-273505-pcsw3vmx 162 20 156 156 CD cord-273505-pcsw3vmx 162 21 ) ) -RRB- cord-273505-pcsw3vmx 162 22 ( ( -LRB- cord-273505-pcsw3vmx 162 23 157 157 CD cord-273505-pcsw3vmx 162 24 ) ) -RRB- cord-273505-pcsw3vmx 162 25 ( ( -LRB- cord-273505-pcsw3vmx 162 26 158 158 CD cord-273505-pcsw3vmx 162 27 ) ) -RRB- cord-273505-pcsw3vmx 162 28 . . . cord-273505-pcsw3vmx 163 1 Moreover moreover RB cord-273505-pcsw3vmx 163 2 , , , cord-273505-pcsw3vmx 163 3 F(ab f(ab NN cord-273505-pcsw3vmx 163 4 ) ) -RRB- cord-273505-pcsw3vmx 163 5 ′ ′ CD cord-273505-pcsw3vmx 163 6 2 2 CD cord-273505-pcsw3vmx 163 7 fragments fragment NNS cord-273505-pcsw3vmx 163 8 , , , cord-273505-pcsw3vmx 163 9 rather rather RB cord-273505-pcsw3vmx 163 10 than than IN cord-273505-pcsw3vmx 163 11 Fc Fc NNP cord-273505-pcsw3vmx 163 12 fragments fragment NNS cord-273505-pcsw3vmx 163 13 , , , cord-273505-pcsw3vmx 163 14 have have VBP cord-273505-pcsw3vmx 163 15 been be VBN cord-273505-pcsw3vmx 163 16 shown show VBN cord-273505-pcsw3vmx 163 17 to to TO cord-273505-pcsw3vmx 163 18 retain retain VB cord-273505-pcsw3vmx 163 19 the the DT cord-273505-pcsw3vmx 163 20 function function NN cord-273505-pcsw3vmx 163 21 of of IN cord-273505-pcsw3vmx 163 22 intact intact JJ cord-273505-pcsw3vmx 163 23 antibodies antibody NNS cord-273505-pcsw3vmx 163 24 in in IN cord-273505-pcsw3vmx 163 25 inhibiting inhibit VBG cord-273505-pcsw3vmx 163 26 Th1 th1 CD cord-273505-pcsw3vmx 163 27 and and CC cord-273505-pcsw3vmx 163 28 Th17 Th17 NNP cord-273505-pcsw3vmx 163 29 ( ( -LRB- cord-273505-pcsw3vmx 163 30 158 158 CD cord-273505-pcsw3vmx 163 31 ) ) -RRB- cord-273505-pcsw3vmx 163 32 . . . cord-273505-pcsw3vmx 164 1 It -PRON- PRP cord-273505-pcsw3vmx 164 2 has have VBZ cord-273505-pcsw3vmx 164 3 been be VBN cord-273505-pcsw3vmx 164 4 proposed propose VBN cord-273505-pcsw3vmx 164 5 that that IN cord-273505-pcsw3vmx 164 6 IVIg ivig PRP cord-273505-pcsw3vmx 164 7 may may MD cord-273505-pcsw3vmx 164 8 neutralize neutralize VB cord-273505-pcsw3vmx 164 9 sphingosine-1-phosphate sphingosine-1-phosphate NNP cord-273505-pcsw3vmx 164 10 ( ( -LRB- cord-273505-pcsw3vmx 164 11 S1P s1p NN cord-273505-pcsw3vmx 164 12 ) ) -RRB- cord-273505-pcsw3vmx 164 13 receptors receptor NNS cord-273505-pcsw3vmx 164 14 on on IN cord-273505-pcsw3vmx 164 15 the the DT cord-273505-pcsw3vmx 164 16 CD4 CD4 NNP cord-273505-pcsw3vmx 164 17 + + CC cord-273505-pcsw3vmx 164 18 T T NNP cord-273505-pcsw3vmx 164 19 cell cell NN cord-273505-pcsw3vmx 164 20 and and CC cord-273505-pcsw3vmx 164 21 downregulate downregulate VB cord-273505-pcsw3vmx 164 22 the the DT cord-273505-pcsw3vmx 164 23 S1P1-mTOR S1P1-mTOR NNP cord-273505-pcsw3vmx 164 24 signaling signal VBG cord-273505-pcsw3vmx 164 25 axis axis NN cord-273505-pcsw3vmx 164 26 , , , cord-273505-pcsw3vmx 164 27 thereby thereby RB cord-273505-pcsw3vmx 164 28 inhibiting inhibit VBG cord-273505-pcsw3vmx 164 29 the the DT cord-273505-pcsw3vmx 164 30 differentiation differentiation NN cord-273505-pcsw3vmx 164 31 and and CC cord-273505-pcsw3vmx 164 32 infiltration infiltration NN cord-273505-pcsw3vmx 164 33 of of IN cord-273505-pcsw3vmx 164 34 Th1 th1 NN cord-273505-pcsw3vmx 164 35 and and CC cord-273505-pcsw3vmx 164 36 Th17 Th17 NNP cord-273505-pcsw3vmx 164 37 cells cell NNS cord-273505-pcsw3vmx 164 38 while while IN cord-273505-pcsw3vmx 164 39 favoring favor VBG cord-273505-pcsw3vmx 164 40 Treg Treg NNP cord-273505-pcsw3vmx 164 41 cells cell NNS cord-273505-pcsw3vmx 164 42 ( ( -LRB- cord-273505-pcsw3vmx 164 43 158 158 CD cord-273505-pcsw3vmx 164 44 ) ) -RRB- cord-273505-pcsw3vmx 164 45 . . . cord-273505-pcsw3vmx 165 1 Interestingly interestingly RB cord-273505-pcsw3vmx 165 2 , , , cord-273505-pcsw3vmx 165 3 monomeric monomeric JJ cord-273505-pcsw3vmx 165 4 IgA IgA NNP cord-273505-pcsw3vmx 165 5 ( ( -LRB- cord-273505-pcsw3vmx 165 6 mIgA mIgA NNP cord-273505-pcsw3vmx 165 7 ) ) -RRB- cord-273505-pcsw3vmx 165 8 isolated isolate VBN cord-273505-pcsw3vmx 165 9 from from IN cord-273505-pcsw3vmx 165 10 a a DT cord-273505-pcsw3vmx 165 11 IVIg ivig JJ cord-273505-pcsw3vmx 165 12 preparation preparation NN cord-273505-pcsw3vmx 165 13 has have VBZ cord-273505-pcsw3vmx 165 14 been be VBN cord-273505-pcsw3vmx 165 15 revealed reveal VBN cord-273505-pcsw3vmx 165 16 to to TO cord-273505-pcsw3vmx 165 17 interfere interfere VB cord-273505-pcsw3vmx 165 18 with with IN cord-273505-pcsw3vmx 165 19 the the DT cord-273505-pcsw3vmx 165 20 STAT3 STAT3 NNP cord-273505-pcsw3vmx 165 21 via via IN cord-273505-pcsw3vmx 165 22 its -PRON- PRP$ cord-273505-pcsw3vmx 165 23 F(ab f(ab NN cord-273505-pcsw3vmx 165 24 ) ) -RRB- cord-273505-pcsw3vmx 165 25 ′ ′ CD cord-273505-pcsw3vmx 165 26 2 2 CD cord-273505-pcsw3vmx 165 27 fragments fragment NNS cord-273505-pcsw3vmx 165 28 and and CC cord-273505-pcsw3vmx 165 29 inhibits inhibit VBZ cord-273505-pcsw3vmx 165 30 the the DT cord-273505-pcsw3vmx 165 31 differentiation differentiation NN cord-273505-pcsw3vmx 165 32 and and CC cord-273505-pcsw3vmx 165 33 expansion expansion NN cord-273505-pcsw3vmx 165 34 of of IN cord-273505-pcsw3vmx 165 35 Th17 Th17 NNP cord-273505-pcsw3vmx 165 36 cells cell NNS cord-273505-pcsw3vmx 165 37 ( ( -LRB- cord-273505-pcsw3vmx 165 38 159 159 CD cord-273505-pcsw3vmx 165 39 ) ) -RRB- cord-273505-pcsw3vmx 165 40 . . . cord-273505-pcsw3vmx 166 1 It -PRON- PRP cord-273505-pcsw3vmx 166 2 is be VBZ cord-273505-pcsw3vmx 166 3 noted note VBN cord-273505-pcsw3vmx 166 4 that that IN cord-273505-pcsw3vmx 166 5 the the DT cord-273505-pcsw3vmx 166 6 proposed propose VBN cord-273505-pcsw3vmx 166 7 mechanism mechanism NN cord-273505-pcsw3vmx 166 8 of of IN cord-273505-pcsw3vmx 166 9 functional functional JJ cord-273505-pcsw3vmx 166 10 T T NNP cord-273505-pcsw3vmx 166 11 cell cell NN cord-273505-pcsw3vmx 166 12 - - HYPH cord-273505-pcsw3vmx 166 13 modulation modulation NN cord-273505-pcsw3vmx 166 14 by by IN cord-273505-pcsw3vmx 166 15 IVIg IVIg NNP cord-273505-pcsw3vmx 166 16 also also RB cord-273505-pcsw3vmx 166 17 includes include VBZ cord-273505-pcsw3vmx 166 18 DC DC NNP cord-273505-pcsw3vmx 166 19 - - HYPH cord-273505-pcsw3vmx 166 20 mediated mediate VBN cord-273505-pcsw3vmx 166 21 effects effect NNS cord-273505-pcsw3vmx 166 22 ; ; : cord-273505-pcsw3vmx 166 23 IVIg ivig NN cord-273505-pcsw3vmx 166 24 - - HYPH cord-273505-pcsw3vmx 166 25 primed prime VBN cord-273505-pcsw3vmx 166 26 DCs dc NNS cord-273505-pcsw3vmx 166 27 can can MD cord-273505-pcsw3vmx 166 28 steer steer VB cord-273505-pcsw3vmx 166 29 non non JJ cord-273505-pcsw3vmx 166 30 - - JJ cord-273505-pcsw3vmx 166 31 Treg treg JJ cord-273505-pcsw3vmx 166 32 cell cell NN cord-273505-pcsw3vmx 166 33 precursors precursor NNS cord-273505-pcsw3vmx 166 34 toward toward IN cord-273505-pcsw3vmx 166 35 a a DT cord-273505-pcsw3vmx 166 36 Treg Treg NNP cord-273505-pcsw3vmx 166 37 differentiation differentiation NN cord-273505-pcsw3vmx 166 38 , , , cord-273505-pcsw3vmx 166 39 and and CC cord-273505-pcsw3vmx 166 40 C c NN cord-273505-pcsw3vmx 166 41 - - HYPH cord-273505-pcsw3vmx 166 42 type type NN cord-273505-pcsw3vmx 166 43 lectins lectin NNS cord-273505-pcsw3vmx 166 44 expressed express VBN cord-273505-pcsw3vmx 166 45 on on IN cord-273505-pcsw3vmx 166 46 DC DC NNP cord-273505-pcsw3vmx 166 47 cells cell NNS cord-273505-pcsw3vmx 166 48 may may MD cord-273505-pcsw3vmx 166 49 be be VB cord-273505-pcsw3vmx 166 50 critical critical JJ cord-273505-pcsw3vmx 166 51 in in IN cord-273505-pcsw3vmx 166 52 this this DT cord-273505-pcsw3vmx 166 53 process process NN cord-273505-pcsw3vmx 166 54 ( ( -LRB- cord-273505-pcsw3vmx 166 55 105 105 CD cord-273505-pcsw3vmx 166 56 , , , cord-273505-pcsw3vmx 166 57 ( ( -LRB- cord-273505-pcsw3vmx 166 58 160 160 CD cord-273505-pcsw3vmx 166 59 ) ) -RRB- cord-273505-pcsw3vmx 166 60 ( ( -LRB- cord-273505-pcsw3vmx 166 61 161 161 CD cord-273505-pcsw3vmx 166 62 ) ) -RRB- cord-273505-pcsw3vmx 166 63 ( ( -LRB- cord-273505-pcsw3vmx 166 64 162 162 CD cord-273505-pcsw3vmx 166 65 ) ) -RRB- cord-273505-pcsw3vmx 166 66 . . . cord-273505-pcsw3vmx 167 1 Novel Novel NNP cord-273505-pcsw3vmx 167 2 Treg Treg NNP cord-273505-pcsw3vmx 167 3 epitope epitope NN cord-273505-pcsw3vmx 167 4 peptides peptide NNS cord-273505-pcsw3vmx 167 5 ( ( -LRB- cord-273505-pcsw3vmx 167 6 Tregitopes Tregitopes NNP cord-273505-pcsw3vmx 167 7 ) ) -RRB- cord-273505-pcsw3vmx 167 8 on on IN cord-273505-pcsw3vmx 167 9 IgG IgG NNP cord-273505-pcsw3vmx 167 10 provide provide VBP cord-273505-pcsw3vmx 167 11 a a DT cord-273505-pcsw3vmx 167 12 further further JJ cord-273505-pcsw3vmx 167 13 explanation explanation NN cord-273505-pcsw3vmx 167 14 of of IN cord-273505-pcsw3vmx 167 15 the the DT cord-273505-pcsw3vmx 167 16 regulatory regulatory JJ cord-273505-pcsw3vmx 167 17 effects effect NNS cord-273505-pcsw3vmx 167 18 of of IN cord-273505-pcsw3vmx 167 19 IVIg ivig NN cord-273505-pcsw3vmx 167 20 on on IN cord-273505-pcsw3vmx 167 21 Treg Treg NNP cord-273505-pcsw3vmx 167 22 cells cell NNS cord-273505-pcsw3vmx 167 23 via via IN cord-273505-pcsw3vmx 167 24 DC DC NNP cord-273505-pcsw3vmx 167 25 - - HYPH cord-273505-pcsw3vmx 167 26 mediated mediate VBN cord-273505-pcsw3vmx 167 27 internalization internalization NN cord-273505-pcsw3vmx 167 28 of of IN cord-273505-pcsw3vmx 167 29 IVIg IVIg NNP cord-273505-pcsw3vmx 167 30 ( ( -LRB- cord-273505-pcsw3vmx 167 31 163 163 CD cord-273505-pcsw3vmx 167 32 ) ) -RRB- cord-273505-pcsw3vmx 167 33 . . . cord-273505-pcsw3vmx 168 1 Tregitopes tregitope NNS cord-273505-pcsw3vmx 168 2 are be VBP cord-273505-pcsw3vmx 168 3 natural natural JJ cord-273505-pcsw3vmx 168 4 T T NNP cord-273505-pcsw3vmx 168 5 cell cell NN cord-273505-pcsw3vmx 168 6 epitopes epitope NNS cord-273505-pcsw3vmx 168 7 of of IN cord-273505-pcsw3vmx 168 8 IgG IgG NNP cord-273505-pcsw3vmx 168 9 , , , cord-273505-pcsw3vmx 168 10 and and CC cord-273505-pcsw3vmx 168 11 the the DT cord-273505-pcsw3vmx 168 12 presentation presentation NN cord-273505-pcsw3vmx 168 13 of of IN cord-273505-pcsw3vmx 168 14 Tregitopes Tregitopes NNP cord-273505-pcsw3vmx 168 15 on on IN cord-273505-pcsw3vmx 168 16 DCs dc NNS cord-273505-pcsw3vmx 168 17 in in IN cord-273505-pcsw3vmx 168 18 the the DT cord-273505-pcsw3vmx 168 19 context context NN cord-273505-pcsw3vmx 168 20 of of IN cord-273505-pcsw3vmx 168 21 MHC MHC NNP cord-273505-pcsw3vmx 168 22 - - HYPH cord-273505-pcsw3vmx 168 23 II II NNP cord-273505-pcsw3vmx 168 24 can can MD cord-273505-pcsw3vmx 168 25 lead lead VB cord-273505-pcsw3vmx 168 26 to to IN cord-273505-pcsw3vmx 168 27 the the DT cord-273505-pcsw3vmx 168 28 activation activation NN cord-273505-pcsw3vmx 168 29 and and CC cord-273505-pcsw3vmx 168 30 expansion expansion NN cord-273505-pcsw3vmx 168 31 of of IN cord-273505-pcsw3vmx 168 32 Treg Treg NNP cord-273505-pcsw3vmx 168 33 cells cell NNS cord-273505-pcsw3vmx 168 34 , , , cord-273505-pcsw3vmx 168 35 reinforcing reinforce VBG cord-273505-pcsw3vmx 168 36 the the DT cord-273505-pcsw3vmx 168 37 immunoregulatory immunoregulatory JJ cord-273505-pcsw3vmx 168 38 effects effect NNS cord-273505-pcsw3vmx 168 39 on on IN cord-273505-pcsw3vmx 168 40 other other JJ cord-273505-pcsw3vmx 168 41 conventional conventional JJ cord-273505-pcsw3vmx 168 42 T t NN cord-273505-pcsw3vmx 168 43 cells cell NNS cord-273505-pcsw3vmx 168 44 ( ( -LRB- cord-273505-pcsw3vmx 168 45 164 164 CD cord-273505-pcsw3vmx 168 46 , , , cord-273505-pcsw3vmx 168 47 165 165 CD cord-273505-pcsw3vmx 168 48 ) ) -RRB- cord-273505-pcsw3vmx 168 49 . . . cord-273505-pcsw3vmx 169 1 CD8 CD8 NNP cord-273505-pcsw3vmx 169 2 + + CC cord-273505-pcsw3vmx 169 3 T T NNP cord-273505-pcsw3vmx 169 4 cells cell NNS cord-273505-pcsw3vmx 169 5 contribute contribute VBP cord-273505-pcsw3vmx 169 6 to to IN cord-273505-pcsw3vmx 169 7 pathogen pathogen NN cord-273505-pcsw3vmx 169 8 clearance clearance NN cord-273505-pcsw3vmx 169 9 and and CC cord-273505-pcsw3vmx 169 10 immune immune JJ cord-273505-pcsw3vmx 169 11 protection protection NN cord-273505-pcsw3vmx 169 12 . . . cord-273505-pcsw3vmx 170 1 However however RB cord-273505-pcsw3vmx 170 2 , , , cord-273505-pcsw3vmx 170 3 cytokines cytokine NNS cord-273505-pcsw3vmx 170 4 and and CC cord-273505-pcsw3vmx 170 5 cytotoxic cytotoxic JJ cord-273505-pcsw3vmx 170 6 granules granule NNS cord-273505-pcsw3vmx 170 7 produced produce VBN cord-273505-pcsw3vmx 170 8 by by IN cord-273505-pcsw3vmx 170 9 activated activate VBN cord-273505-pcsw3vmx 170 10 CD8 CD8 NNP cord-273505-pcsw3vmx 170 11 + + CC cord-273505-pcsw3vmx 170 12 T T NNP cord-273505-pcsw3vmx 170 13 cells cell NNS cord-273505-pcsw3vmx 170 14 may may MD cord-273505-pcsw3vmx 170 15 exaggerate exaggerate VB cord-273505-pcsw3vmx 170 16 cytokine cytokine JJ cord-273505-pcsw3vmx 170 17 storms storm NNS cord-273505-pcsw3vmx 170 18 and and CC cord-273505-pcsw3vmx 170 19 are be VBP cord-273505-pcsw3vmx 170 20 partially partially RB cord-273505-pcsw3vmx 170 21 implicated implicate VBN cord-273505-pcsw3vmx 170 22 in in IN cord-273505-pcsw3vmx 170 23 the the DT cord-273505-pcsw3vmx 170 24 immunopathology immunopathology NN cord-273505-pcsw3vmx 170 25 during during IN cord-273505-pcsw3vmx 170 26 respiratory respiratory JJ cord-273505-pcsw3vmx 170 27 viral viral JJ cord-273505-pcsw3vmx 170 28 infections infection NNS cord-273505-pcsw3vmx 170 29 ( ( -LRB- cord-273505-pcsw3vmx 170 30 166 166 CD cord-273505-pcsw3vmx 170 31 , , , cord-273505-pcsw3vmx 170 32 167 167 CD cord-273505-pcsw3vmx 170 33 ) ) -RRB- cord-273505-pcsw3vmx 170 34 . . . cord-273505-pcsw3vmx 171 1 Both both DT cord-273505-pcsw3vmx 171 2 a a DT cord-273505-pcsw3vmx 171 3 substantial substantial JJ cord-273505-pcsw3vmx 171 4 reduction reduction NN cord-273505-pcsw3vmx 171 5 of of IN cord-273505-pcsw3vmx 171 6 CD8 CD8 NNP cord-273505-pcsw3vmx 171 7 + + CC cord-273505-pcsw3vmx 171 8 T T NNP cord-273505-pcsw3vmx 171 9 cell cell NN cord-273505-pcsw3vmx 171 10 counts count VBZ cord-273505-pcsw3vmx 171 11 in in IN cord-273505-pcsw3vmx 171 12 peripheral peripheral JJ cord-273505-pcsw3vmx 171 13 blood blood NN cord-273505-pcsw3vmx 171 14 , , , cord-273505-pcsw3vmx 171 15 and and CC cord-273505-pcsw3vmx 171 16 hyperactivation hyperactivation VB cord-273505-pcsw3vmx 171 17 with with IN cord-273505-pcsw3vmx 171 18 extensive extensive JJ cord-273505-pcsw3vmx 171 19 expression expression NN cord-273505-pcsw3vmx 171 20 of of IN cord-273505-pcsw3vmx 171 21 surface surface NN cord-273505-pcsw3vmx 171 22 activation activation NN cord-273505-pcsw3vmx 171 23 markers marker NNS cord-273505-pcsw3vmx 171 24 ( ( -LRB- cord-273505-pcsw3vmx 171 25 HLA HLA NNP cord-273505-pcsw3vmx 171 26 - - HYPH cord-273505-pcsw3vmx 171 27 DR DR NNP cord-273505-pcsw3vmx 171 28 and and CC cord-273505-pcsw3vmx 171 29 CD38 CD38 NNP cord-273505-pcsw3vmx 171 30 ) ) -RRB- cord-273505-pcsw3vmx 171 31 and and CC cord-273505-pcsw3vmx 171 32 cytotoxic cytotoxic JJ cord-273505-pcsw3vmx 171 33 granules granule NNS cord-273505-pcsw3vmx 171 34 in in IN cord-273505-pcsw3vmx 171 35 CD8 CD8 NNP cord-273505-pcsw3vmx 171 36 + + CC cord-273505-pcsw3vmx 171 37 T T NNP cord-273505-pcsw3vmx 171 38 cells cell NNS cord-273505-pcsw3vmx 171 39 are be VBP cord-273505-pcsw3vmx 171 40 commonly commonly RB cord-273505-pcsw3vmx 171 41 observed observe VBN cord-273505-pcsw3vmx 171 42 in in IN cord-273505-pcsw3vmx 171 43 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 171 44 patients patient NNS cord-273505-pcsw3vmx 171 45 ( ( -LRB- cord-273505-pcsw3vmx 171 46 139 139 CD cord-273505-pcsw3vmx 171 47 , , , cord-273505-pcsw3vmx 171 48 168 168 CD cord-273505-pcsw3vmx 171 49 ) ) -RRB- cord-273505-pcsw3vmx 171 50 . . . cord-273505-pcsw3vmx 172 1 An an DT cord-273505-pcsw3vmx 172 2 accompanying accompany VBG cord-273505-pcsw3vmx 172 3 functional functional JJ cord-273505-pcsw3vmx 172 4 exhaustion exhaustion NN cord-273505-pcsw3vmx 172 5 of of IN cord-273505-pcsw3vmx 172 6 CD8 CD8 NNP cord-273505-pcsw3vmx 172 7 + + CC cord-273505-pcsw3vmx 173 1 T t NN cord-273505-pcsw3vmx 173 2 cells cell NNS cord-273505-pcsw3vmx 173 3 is be VBZ cord-273505-pcsw3vmx 173 4 furthermore furthermore RB cord-273505-pcsw3vmx 173 5 detected detect VBN cord-273505-pcsw3vmx 173 6 in in IN cord-273505-pcsw3vmx 173 7 severe severe JJ cord-273505-pcsw3vmx 173 8 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 173 9 patients patient NNS cord-273505-pcsw3vmx 173 10 ( ( -LRB- cord-273505-pcsw3vmx 173 11 131 131 CD cord-273505-pcsw3vmx 173 12 ) ) -RRB- cord-273505-pcsw3vmx 173 13 . . . cord-273505-pcsw3vmx 174 1 Unlike unlike IN cord-273505-pcsw3vmx 174 2 influenza influenza NN cord-273505-pcsw3vmx 174 3 or or CC cord-273505-pcsw3vmx 174 4 RSV RSV NNP cord-273505-pcsw3vmx 174 5 , , , cord-273505-pcsw3vmx 174 6 the the DT cord-273505-pcsw3vmx 174 7 impaired impaired JJ cord-273505-pcsw3vmx 174 8 function function NN cord-273505-pcsw3vmx 174 9 of of IN cord-273505-pcsw3vmx 174 10 CD8 CD8 NNP cord-273505-pcsw3vmx 174 11 + + CC cord-273505-pcsw3vmx 174 12 T T NNP cord-273505-pcsw3vmx 174 13 cells cell NNS cord-273505-pcsw3vmx 174 14 during during IN cord-273505-pcsw3vmx 174 15 SARS SARS NNP cord-273505-pcsw3vmx 174 16 - - HYPH cord-273505-pcsw3vmx 174 17 CoV-2 CoV-2 NNP cord-273505-pcsw3vmx 174 18 infection infection NN cord-273505-pcsw3vmx 174 19 suggests suggest VBZ cord-273505-pcsw3vmx 174 20 that that IN cord-273505-pcsw3vmx 174 21 these these DT cord-273505-pcsw3vmx 174 22 cells cell NNS cord-273505-pcsw3vmx 174 23 may may MD cord-273505-pcsw3vmx 174 24 not not RB cord-273505-pcsw3vmx 174 25 be be VB cord-273505-pcsw3vmx 174 26 major major JJ cord-273505-pcsw3vmx 174 27 contributors contributor NNS cord-273505-pcsw3vmx 174 28 to to IN cord-273505-pcsw3vmx 174 29 the the DT cord-273505-pcsw3vmx 174 30 cytokine cytokine NN cord-273505-pcsw3vmx 174 31 storm storm NN cord-273505-pcsw3vmx 174 32 in in IN cord-273505-pcsw3vmx 174 33 severe severe JJ cord-273505-pcsw3vmx 174 34 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 174 35 patients patient NNS cord-273505-pcsw3vmx 174 36 ( ( -LRB- cord-273505-pcsw3vmx 174 37 166 166 CD cord-273505-pcsw3vmx 174 38 , , , cord-273505-pcsw3vmx 174 39 167 167 CD cord-273505-pcsw3vmx 174 40 , , , cord-273505-pcsw3vmx 174 41 169 169 CD cord-273505-pcsw3vmx 174 42 ) ) -RRB- cord-273505-pcsw3vmx 174 43 . . . cord-273505-pcsw3vmx 175 1 However however RB cord-273505-pcsw3vmx 175 2 , , , cord-273505-pcsw3vmx 175 3 overactivation overactivation NN cord-273505-pcsw3vmx 175 4 and and CC cord-273505-pcsw3vmx 175 5 subsequent subsequent JJ cord-273505-pcsw3vmx 175 6 functional functional JJ cord-273505-pcsw3vmx 175 7 exhaustion exhaustion NN cord-273505-pcsw3vmx 175 8 of of IN cord-273505-pcsw3vmx 175 9 CD8 CD8 NNP cord-273505-pcsw3vmx 175 10 + + CC cord-273505-pcsw3vmx 175 11 T T NNP cord-273505-pcsw3vmx 175 12 cells cell NNS cord-273505-pcsw3vmx 175 13 may may MD cord-273505-pcsw3vmx 175 14 correlate correlate VB cord-273505-pcsw3vmx 175 15 with with IN cord-273505-pcsw3vmx 175 16 disease disease NN cord-273505-pcsw3vmx 175 17 progression progression NN cord-273505-pcsw3vmx 175 18 ( ( -LRB- cord-273505-pcsw3vmx 175 19 131 131 CD cord-273505-pcsw3vmx 175 20 ) ) -RRB- cord-273505-pcsw3vmx 175 21 . . . cord-273505-pcsw3vmx 176 1 After after IN cord-273505-pcsw3vmx 176 2 effective effective JJ cord-273505-pcsw3vmx 176 3 high high JJ cord-273505-pcsw3vmx 176 4 - - HYPH cord-273505-pcsw3vmx 176 5 dose dose NN cord-273505-pcsw3vmx 176 6 IVIg ivig NN cord-273505-pcsw3vmx 176 7 therapy therapy NN cord-273505-pcsw3vmx 176 8 , , , cord-273505-pcsw3vmx 176 9 the the DT cord-273505-pcsw3vmx 176 10 expression expression NN cord-273505-pcsw3vmx 176 11 of of IN cord-273505-pcsw3vmx 176 12 HLA HLA NNP cord-273505-pcsw3vmx 176 13 - - HYPH cord-273505-pcsw3vmx 176 14 DR DR NNP cord-273505-pcsw3vmx 176 15 and and CC cord-273505-pcsw3vmx 176 16 the the DT cord-273505-pcsw3vmx 176 17 proportion proportion NN cord-273505-pcsw3vmx 176 18 of of IN cord-273505-pcsw3vmx 176 19 extensive extensive JJ cord-273505-pcsw3vmx 176 20 highly highly RB cord-273505-pcsw3vmx 176 21 activated activate VBN cord-273505-pcsw3vmx 176 22 Vβ Vβ NNP cord-273505-pcsw3vmx 176 23 elements element NNS cord-273505-pcsw3vmx 176 24 of of IN cord-273505-pcsw3vmx 176 25 CD8 CD8 NNP cord-273505-pcsw3vmx 176 26 + + CC cord-273505-pcsw3vmx 176 27 T T NNP cord-273505-pcsw3vmx 176 28 cells cell NNS cord-273505-pcsw3vmx 176 29 decrease decrease VBP cord-273505-pcsw3vmx 176 30 in in IN cord-273505-pcsw3vmx 176 31 patients patient NNS cord-273505-pcsw3vmx 176 32 with with IN cord-273505-pcsw3vmx 176 33 autoimmune autoimmune JJ cord-273505-pcsw3vmx 176 34 diseases disease NNS cord-273505-pcsw3vmx 176 35 ( ( -LRB- cord-273505-pcsw3vmx 176 36 170 170 CD cord-273505-pcsw3vmx 176 37 , , , cord-273505-pcsw3vmx 176 38 171 171 CD cord-273505-pcsw3vmx 176 39 ) ) -RRB- cord-273505-pcsw3vmx 176 40 . . . cord-273505-pcsw3vmx 177 1 In in IN cord-273505-pcsw3vmx 177 2 vitro vitro FW cord-273505-pcsw3vmx 177 3 and and CC cord-273505-pcsw3vmx 177 4 animal animal NN cord-273505-pcsw3vmx 177 5 model model NN cord-273505-pcsw3vmx 177 6 studies study NNS cord-273505-pcsw3vmx 177 7 report report VBP cord-273505-pcsw3vmx 177 8 similar similar JJ cord-273505-pcsw3vmx 177 9 inhibitory inhibitory JJ cord-273505-pcsw3vmx 177 10 effects effect NNS cord-273505-pcsw3vmx 177 11 ( ( -LRB- cord-273505-pcsw3vmx 177 12 172 172 CD cord-273505-pcsw3vmx 177 13 , , , cord-273505-pcsw3vmx 177 14 173 173 CD cord-273505-pcsw3vmx 177 15 ) ) -RRB- cord-273505-pcsw3vmx 177 16 . . . cord-273505-pcsw3vmx 178 1 As as IN cord-273505-pcsw3vmx 178 2 no no DT cord-273505-pcsw3vmx 178 3 FcγRs FcγRs NNP cord-273505-pcsw3vmx 178 4 are be VBP cord-273505-pcsw3vmx 178 5 expressed express VBN cord-273505-pcsw3vmx 178 6 on on IN cord-273505-pcsw3vmx 178 7 T T NNP cord-273505-pcsw3vmx 178 8 cells cell NNS cord-273505-pcsw3vmx 178 9 , , , cord-273505-pcsw3vmx 178 10 the the DT cord-273505-pcsw3vmx 178 11 modulation modulation NN cord-273505-pcsw3vmx 178 12 of of IN cord-273505-pcsw3vmx 178 13 IVIg ivig NN cord-273505-pcsw3vmx 178 14 on on IN cord-273505-pcsw3vmx 178 15 CD8 CD8 NNP cord-273505-pcsw3vmx 178 16 + + CC cord-273505-pcsw3vmx 178 17 T T NNP cord-273505-pcsw3vmx 178 18 cells cell NNS cord-273505-pcsw3vmx 178 19 may may MD cord-273505-pcsw3vmx 178 20 largely largely RB cord-273505-pcsw3vmx 178 21 depend depend VB cord-273505-pcsw3vmx 178 22 on on IN cord-273505-pcsw3vmx 178 23 specific specific JJ cord-273505-pcsw3vmx 178 24 antibodies antibody NNS cord-273505-pcsw3vmx 178 25 present present JJ cord-273505-pcsw3vmx 178 26 in in IN cord-273505-pcsw3vmx 178 27 the the DT cord-273505-pcsw3vmx 178 28 IVIg ivig JJ cord-273505-pcsw3vmx 178 29 preparation preparation NN cord-273505-pcsw3vmx 178 30 , , , cord-273505-pcsw3vmx 178 31 which which WDT cord-273505-pcsw3vmx 178 32 directly directly RB cord-273505-pcsw3vmx 178 33 bind bind VBP cord-273505-pcsw3vmx 178 34 to to IN cord-273505-pcsw3vmx 178 35 T t NN cord-273505-pcsw3vmx 178 36 cells cell NNS cord-273505-pcsw3vmx 178 37 , , , cord-273505-pcsw3vmx 178 38 or or CC cord-273505-pcsw3vmx 178 39 through through IN cord-273505-pcsw3vmx 178 40 interactions interaction NNS cord-273505-pcsw3vmx 178 41 between between IN cord-273505-pcsw3vmx 178 42 APC APC NNP cord-273505-pcsw3vmx 178 43 and and CC cord-273505-pcsw3vmx 178 44 TCR TCR NNP cord-273505-pcsw3vmx 178 45 signaling signal VBG cord-273505-pcsw3vmx 178 46 ( ( -LRB- cord-273505-pcsw3vmx 178 47 174 174 CD cord-273505-pcsw3vmx 178 48 ) ) -RRB- cord-273505-pcsw3vmx 178 49 . . . cord-273505-pcsw3vmx 179 1 For for IN cord-273505-pcsw3vmx 179 2 example example NN cord-273505-pcsw3vmx 179 3 , , , cord-273505-pcsw3vmx 179 4 it -PRON- PRP cord-273505-pcsw3vmx 179 5 has have VBZ cord-273505-pcsw3vmx 179 6 been be VBN cord-273505-pcsw3vmx 179 7 shown show VBN cord-273505-pcsw3vmx 179 8 that that IN cord-273505-pcsw3vmx 179 9 the the DT cord-273505-pcsw3vmx 179 10 anti anti JJ cord-273505-pcsw3vmx 179 11 - - JJ cord-273505-pcsw3vmx 179 12 B07.75 b07.75 JJ cord-273505-pcsw3vmx 179 13 - - HYPH cord-273505-pcsw3vmx 179 14 84 84 CD cord-273505-pcsw3vmx 179 15 peptide peptide NN cord-273505-pcsw3vmx 179 16 antibodies antibody NNS cord-273505-pcsw3vmx 179 17 in in IN cord-273505-pcsw3vmx 179 18 IVIg IVIg NNP cord-273505-pcsw3vmx 179 19 may may MD cord-273505-pcsw3vmx 179 20 be be VB cord-273505-pcsw3vmx 179 21 able able JJ cord-273505-pcsw3vmx 179 22 to to TO cord-273505-pcsw3vmx 179 23 inhibit inhibit VB cord-273505-pcsw3vmx 179 24 HLA HLA NNP cord-273505-pcsw3vmx 179 25 class class NN cord-273505-pcsw3vmx 179 26 I i NN cord-273505-pcsw3vmx 179 27 - - HYPH cord-273505-pcsw3vmx 179 28 restricted restrict VBN cord-273505-pcsw3vmx 179 29 cytotoxicity cytotoxicity NN cord-273505-pcsw3vmx 179 30 of of IN cord-273505-pcsw3vmx 179 31 CD8 CD8 NNP cord-273505-pcsw3vmx 179 32 + + CC cord-273505-pcsw3vmx 179 33 T T NNP cord-273505-pcsw3vmx 179 34 cells cell NNS cord-273505-pcsw3vmx 179 35 via via IN cord-273505-pcsw3vmx 179 36 their -PRON- PRP$ cord-273505-pcsw3vmx 179 37 F(ab f(ab NN cord-273505-pcsw3vmx 179 38 ) ) -RRB- cord-273505-pcsw3vmx 179 39 ′ ′ CD cord-273505-pcsw3vmx 179 40 2 2 CD cord-273505-pcsw3vmx 179 41 fragment fragment NN cord-273505-pcsw3vmx 179 42 ( ( -LRB- cord-273505-pcsw3vmx 179 43 175 175 CD cord-273505-pcsw3vmx 179 44 ) ) -RRB- cord-273505-pcsw3vmx 179 45 . . . cord-273505-pcsw3vmx 180 1 Apart apart RB cord-273505-pcsw3vmx 180 2 from from IN cord-273505-pcsw3vmx 180 3 that that DT cord-273505-pcsw3vmx 180 4 , , , cord-273505-pcsw3vmx 180 5 a a DT cord-273505-pcsw3vmx 180 6 saturation saturation NN cord-273505-pcsw3vmx 180 7 of of IN cord-273505-pcsw3vmx 180 8 activating activate VBG cord-273505-pcsw3vmx 180 9 FcγRs FcγRs NNP cord-273505-pcsw3vmx 180 10 on on IN cord-273505-pcsw3vmx 180 11 APC APC NNP cord-273505-pcsw3vmx 180 12 results result NNS cord-273505-pcsw3vmx 180 13 in in IN cord-273505-pcsw3vmx 180 14 reduced reduce VBN cord-273505-pcsw3vmx 180 15 immune immune JJ cord-273505-pcsw3vmx 180 16 complex complex JJ cord-273505-pcsw3vmx 180 17 internalization internalization NN cord-273505-pcsw3vmx 180 18 and and CC cord-273505-pcsw3vmx 180 19 presentation presentation NN cord-273505-pcsw3vmx 180 20 , , , cord-273505-pcsw3vmx 180 21 further further RB cord-273505-pcsw3vmx 180 22 contributing contribute VBG cord-273505-pcsw3vmx 180 23 to to IN cord-273505-pcsw3vmx 180 24 the the DT cord-273505-pcsw3vmx 180 25 inhibitory inhibitory JJ cord-273505-pcsw3vmx 180 26 effects effect NNS cord-273505-pcsw3vmx 180 27 of of IN cord-273505-pcsw3vmx 180 28 high high JJ cord-273505-pcsw3vmx 180 29 - - HYPH cord-273505-pcsw3vmx 180 30 dose dose NN cord-273505-pcsw3vmx 180 31 IVIg ivig NN cord-273505-pcsw3vmx 180 32 on on IN cord-273505-pcsw3vmx 180 33 CD8 CD8 NNP cord-273505-pcsw3vmx 180 34 + + CC cord-273505-pcsw3vmx 180 35 T T NNP cord-273505-pcsw3vmx 180 36 cells cell NNS cord-273505-pcsw3vmx 180 37 ( ( -LRB- cord-273505-pcsw3vmx 180 38 172 172 CD cord-273505-pcsw3vmx 180 39 , , , cord-273505-pcsw3vmx 180 40 173 173 CD cord-273505-pcsw3vmx 180 41 ) ) -RRB- cord-273505-pcsw3vmx 180 42 . . . cord-273505-pcsw3vmx 181 1 With with IN cord-273505-pcsw3vmx 181 2 assistance assistance NN cord-273505-pcsw3vmx 181 3 from from IN cord-273505-pcsw3vmx 181 4 helper helper NN cord-273505-pcsw3vmx 181 5 T T NNP cord-273505-pcsw3vmx 181 6 cells cell NNS cord-273505-pcsw3vmx 181 7 and and CC cord-273505-pcsw3vmx 181 8 stimulation stimulation NN cord-273505-pcsw3vmx 181 9 from from IN cord-273505-pcsw3vmx 181 10 cytokines cytokine NNS cord-273505-pcsw3vmx 181 11 , , , cord-273505-pcsw3vmx 181 12 B b NN cord-273505-pcsw3vmx 181 13 cells cell NNS cord-273505-pcsw3vmx 181 14 are be VBP cord-273505-pcsw3vmx 181 15 activated activate VBN cord-273505-pcsw3vmx 181 16 and and CC cord-273505-pcsw3vmx 181 17 differentiated differentiate VBN cord-273505-pcsw3vmx 181 18 into into IN cord-273505-pcsw3vmx 181 19 plasma plasma NN cord-273505-pcsw3vmx 181 20 cells cell NNS cord-273505-pcsw3vmx 181 21 to to TO cord-273505-pcsw3vmx 181 22 produce produce VB cord-273505-pcsw3vmx 181 23 antibodies antibody NNS cord-273505-pcsw3vmx 181 24 and and CC cord-273505-pcsw3vmx 181 25 contribute contribute VB cord-273505-pcsw3vmx 181 26 to to IN cord-273505-pcsw3vmx 181 27 humoral humoral JJ cord-273505-pcsw3vmx 181 28 immunity immunity NN cord-273505-pcsw3vmx 181 29 ( ( -LRB- cord-273505-pcsw3vmx 181 30 169 169 CD cord-273505-pcsw3vmx 181 31 , , , cord-273505-pcsw3vmx 181 32 176 176 CD cord-273505-pcsw3vmx 181 33 ) ) -RRB- cord-273505-pcsw3vmx 181 34 . . . cord-273505-pcsw3vmx 182 1 Apart apart RB cord-273505-pcsw3vmx 182 2 from from IN cord-273505-pcsw3vmx 182 3 the the DT cord-273505-pcsw3vmx 182 4 generation generation NN cord-273505-pcsw3vmx 182 5 of of IN cord-273505-pcsw3vmx 182 6 antibodies antibody NNS cord-273505-pcsw3vmx 182 7 , , , cord-273505-pcsw3vmx 182 8 IL-6 IL-6 NNP cord-273505-pcsw3vmx 182 9 produced produce VBN cord-273505-pcsw3vmx 182 10 by by IN cord-273505-pcsw3vmx 182 11 activated activate VBN cord-273505-pcsw3vmx 182 12 B B NNP cord-273505-pcsw3vmx 182 13 cells cell NNS cord-273505-pcsw3vmx 182 14 is be VBZ cord-273505-pcsw3vmx 182 15 also also RB cord-273505-pcsw3vmx 182 16 considered consider VBN cord-273505-pcsw3vmx 182 17 as as IN cord-273505-pcsw3vmx 182 18 a a DT cord-273505-pcsw3vmx 182 19 possible possible JJ cord-273505-pcsw3vmx 182 20 booster booster NN cord-273505-pcsw3vmx 182 21 of of IN cord-273505-pcsw3vmx 182 22 the the DT cord-273505-pcsw3vmx 182 23 cytokine cytokine NN cord-273505-pcsw3vmx 182 24 storm storm NN cord-273505-pcsw3vmx 182 25 and and CC cord-273505-pcsw3vmx 182 26 immunopathology immunopathology NN cord-273505-pcsw3vmx 182 27 in in IN cord-273505-pcsw3vmx 182 28 autoimmune autoimmune JJ cord-273505-pcsw3vmx 182 29 disease disease NN cord-273505-pcsw3vmx 182 30 ( ( -LRB- cord-273505-pcsw3vmx 182 31 177 177 CD cord-273505-pcsw3vmx 182 32 , , , cord-273505-pcsw3vmx 182 33 178 178 CD cord-273505-pcsw3vmx 182 34 ) ) -RRB- cord-273505-pcsw3vmx 182 35 . . . cord-273505-pcsw3vmx 183 1 The the DT cord-273505-pcsw3vmx 183 2 rapid rapid JJ cord-273505-pcsw3vmx 183 3 reduction reduction NN cord-273505-pcsw3vmx 183 4 of of IN cord-273505-pcsw3vmx 183 5 peripheral peripheral JJ cord-273505-pcsw3vmx 183 6 B b NN cord-273505-pcsw3vmx 183 7 cells cell NNS cord-273505-pcsw3vmx 183 8 is be VBZ cord-273505-pcsw3vmx 183 9 also also RB cord-273505-pcsw3vmx 183 10 a a DT cord-273505-pcsw3vmx 183 11 significant significant JJ cord-273505-pcsw3vmx 183 12 characteristic characteristic NN cord-273505-pcsw3vmx 183 13 of of IN cord-273505-pcsw3vmx 183 14 severe severe JJ cord-273505-pcsw3vmx 183 15 COIVD-19 coivd-19 JJ cord-273505-pcsw3vmx 183 16 patients patient NNS cord-273505-pcsw3vmx 183 17 , , , cord-273505-pcsw3vmx 183 18 yet yet CC cord-273505-pcsw3vmx 183 19 the the DT cord-273505-pcsw3vmx 183 20 exact exact JJ cord-273505-pcsw3vmx 183 21 mechanisms mechanism NNS cord-273505-pcsw3vmx 183 22 underlying underlie VBG cord-273505-pcsw3vmx 184 1 this this DT cord-273505-pcsw3vmx 184 2 accelerated accelerated JJ cord-273505-pcsw3vmx 184 3 lymphocyte lymphocyte NN cord-273505-pcsw3vmx 184 4 loss loss NN cord-273505-pcsw3vmx 184 5 remain remain VBP cord-273505-pcsw3vmx 184 6 unclear unclear JJ cord-273505-pcsw3vmx 184 7 ( ( -LRB- cord-273505-pcsw3vmx 184 8 17 17 CD cord-273505-pcsw3vmx 184 9 , , , cord-273505-pcsw3vmx 184 10 179 179 CD cord-273505-pcsw3vmx 184 11 ) ) -RRB- cord-273505-pcsw3vmx 184 12 . . . cord-273505-pcsw3vmx 185 1 Although although IN cord-273505-pcsw3vmx 185 2 there there EX cord-273505-pcsw3vmx 185 3 is be VBZ cord-273505-pcsw3vmx 185 4 so so RB cord-273505-pcsw3vmx 185 5 far far RB cord-273505-pcsw3vmx 185 6 no no DT cord-273505-pcsw3vmx 185 7 reliable reliable JJ cord-273505-pcsw3vmx 185 8 evidence evidence NN cord-273505-pcsw3vmx 185 9 correlating correlate VBG cord-273505-pcsw3vmx 185 10 an an DT cord-273505-pcsw3vmx 185 11 overactivation overactivation NN cord-273505-pcsw3vmx 185 12 of of IN cord-273505-pcsw3vmx 185 13 B b NN cord-273505-pcsw3vmx 185 14 cells cell NNS cord-273505-pcsw3vmx 185 15 with with IN cord-273505-pcsw3vmx 185 16 the the DT cord-273505-pcsw3vmx 185 17 development development NN cord-273505-pcsw3vmx 185 18 of of IN cord-273505-pcsw3vmx 185 19 cytokine cytokine JJ cord-273505-pcsw3vmx 185 20 storms storm NNS cord-273505-pcsw3vmx 185 21 during during IN cord-273505-pcsw3vmx 185 22 respiratory respiratory JJ cord-273505-pcsw3vmx 185 23 viral viral JJ cord-273505-pcsw3vmx 185 24 infections infection NNS cord-273505-pcsw3vmx 185 25 , , , cord-273505-pcsw3vmx 185 26 the the DT cord-273505-pcsw3vmx 185 27 production production NN cord-273505-pcsw3vmx 185 28 of of IN cord-273505-pcsw3vmx 185 29 pro pro JJ cord-273505-pcsw3vmx 185 30 - - JJ cord-273505-pcsw3vmx 185 31 inflammatory inflammatory JJ cord-273505-pcsw3vmx 185 32 cytokines cytokine NNS cord-273505-pcsw3vmx 185 33 by by IN cord-273505-pcsw3vmx 185 34 B b NN cord-273505-pcsw3vmx 185 35 cells cell NNS cord-273505-pcsw3vmx 185 36 has have VBZ cord-273505-pcsw3vmx 185 37 been be VBN cord-273505-pcsw3vmx 185 38 proposed propose VBN cord-273505-pcsw3vmx 185 39 to to TO cord-273505-pcsw3vmx 185 40 play play VB cord-273505-pcsw3vmx 185 41 a a DT cord-273505-pcsw3vmx 185 42 key key JJ cord-273505-pcsw3vmx 185 43 role role NN cord-273505-pcsw3vmx 185 44 in in IN cord-273505-pcsw3vmx 185 45 the the DT cord-273505-pcsw3vmx 185 46 cytokine cytokine NN cord-273505-pcsw3vmx 185 47 cascade cascade NN cord-273505-pcsw3vmx 185 48 in in IN cord-273505-pcsw3vmx 185 49 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 185 50 ( ( -LRB- cord-273505-pcsw3vmx 185 51 180 180 CD cord-273505-pcsw3vmx 185 52 ) ) -RRB- cord-273505-pcsw3vmx 185 53 ( ( -LRB- cord-273505-pcsw3vmx 185 54 181 181 CD cord-273505-pcsw3vmx 185 55 ) ) -RRB- cord-273505-pcsw3vmx 185 56 ( ( -LRB- cord-273505-pcsw3vmx 185 57 182 182 CD cord-273505-pcsw3vmx 185 58 ) ) -RRB- cord-273505-pcsw3vmx 185 59 . . . cord-273505-pcsw3vmx 186 1 Effects effect NNS cord-273505-pcsw3vmx 186 2 of of IN cord-273505-pcsw3vmx 186 3 IVIg ivig NN cord-273505-pcsw3vmx 186 4 on on IN cord-273505-pcsw3vmx 186 5 B b NN cord-273505-pcsw3vmx 186 6 cells cell NNS cord-273505-pcsw3vmx 186 7 vary vary VBP cord-273505-pcsw3vmx 186 8 with with IN cord-273505-pcsw3vmx 186 9 the the DT cord-273505-pcsw3vmx 186 10 dosage dosage NN cord-273505-pcsw3vmx 186 11 : : : cord-273505-pcsw3vmx 186 12 at at IN cord-273505-pcsw3vmx 186 13 low low JJ cord-273505-pcsw3vmx 186 14 doses dose NNS cord-273505-pcsw3vmx 186 15 , , , cord-273505-pcsw3vmx 186 16 IVIg IVIg NNP cord-273505-pcsw3vmx 186 17 induces induce VBZ cord-273505-pcsw3vmx 186 18 proliferation proliferation NN cord-273505-pcsw3vmx 186 19 of of IN cord-273505-pcsw3vmx 186 20 B b NN cord-273505-pcsw3vmx 186 21 cells cell NNS cord-273505-pcsw3vmx 186 22 and and CC cord-273505-pcsw3vmx 186 23 the the DT cord-273505-pcsw3vmx 186 24 production production NN cord-273505-pcsw3vmx 186 25 of of IN cord-273505-pcsw3vmx 186 26 antibodies antibody NNS cord-273505-pcsw3vmx 186 27 ( ( -LRB- cord-273505-pcsw3vmx 186 28 183 183 CD cord-273505-pcsw3vmx 186 29 , , , cord-273505-pcsw3vmx 186 30 184 184 CD cord-273505-pcsw3vmx 186 31 ) ) -RRB- cord-273505-pcsw3vmx 186 32 . . . cord-273505-pcsw3vmx 187 1 On on IN cord-273505-pcsw3vmx 187 2 the the DT cord-273505-pcsw3vmx 187 3 contrary contrary JJ cord-273505-pcsw3vmx 187 4 , , , cord-273505-pcsw3vmx 187 5 high high JJ cord-273505-pcsw3vmx 187 6 - - HYPH cord-273505-pcsw3vmx 187 7 dose dose NN cord-273505-pcsw3vmx 187 8 IVIg ivig NN cord-273505-pcsw3vmx 187 9 inhibits inhibit VBZ cord-273505-pcsw3vmx 187 10 the the DT cord-273505-pcsw3vmx 187 11 activation activation NN cord-273505-pcsw3vmx 187 12 of of IN cord-273505-pcsw3vmx 187 13 B b NN cord-273505-pcsw3vmx 187 14 cells cell NNS cord-273505-pcsw3vmx 187 15 via via IN cord-273505-pcsw3vmx 187 16 both both DT cord-273505-pcsw3vmx 187 17 F(ab f(ab NN cord-273505-pcsw3vmx 187 18 ) ) -RRB- cord-273505-pcsw3vmx 187 19 ′ ′ CD cord-273505-pcsw3vmx 187 20 2 2 CD cord-273505-pcsw3vmx 187 21 -mediated -mediated JJ cord-273505-pcsw3vmx 187 22 mechanisms mechanism NNS cord-273505-pcsw3vmx 187 23 ( ( -LRB- cord-273505-pcsw3vmx 187 24 e.g. e.g. RB cord-273505-pcsw3vmx 187 25 , , , cord-273505-pcsw3vmx 187 26 neutralizing neutralize VBG cord-273505-pcsw3vmx 187 27 APRIL APRIL NNP cord-273505-pcsw3vmx 187 28 , , , cord-273505-pcsw3vmx 187 29 BAFF BAFF NNP cord-273505-pcsw3vmx 187 30 , , , cord-273505-pcsw3vmx 187 31 and and CC cord-273505-pcsw3vmx 187 32 Fas Fas NNP cord-273505-pcsw3vmx 187 33 ) ) -RRB- cord-273505-pcsw3vmx 187 34 and and CC cord-273505-pcsw3vmx 187 35 Fc Fc NNP cord-273505-pcsw3vmx 187 36 - - HYPH cord-273505-pcsw3vmx 187 37 mediated mediate VBN cord-273505-pcsw3vmx 187 38 mechanisms mechanism NNS cord-273505-pcsw3vmx 187 39 acting act VBG cord-273505-pcsw3vmx 187 40 on on IN cord-273505-pcsw3vmx 187 41 inhibitory inhibitory JJ cord-273505-pcsw3vmx 187 42 FcRs FcRs NNP cord-273505-pcsw3vmx 187 43 ( ( -LRB- cord-273505-pcsw3vmx 187 44 e.g. e.g. RB cord-273505-pcsw3vmx 187 45 , , , cord-273505-pcsw3vmx 187 46 FcγRIIB FcγRIIB NNP cord-273505-pcsw3vmx 187 47 and and CC cord-273505-pcsw3vmx 187 48 CD22 CD22 NNP cord-273505-pcsw3vmx 187 49 ) ) -RRB- cord-273505-pcsw3vmx 187 50 , , , cord-273505-pcsw3vmx 187 51 as as RB cord-273505-pcsw3vmx 187 52 well well RB cord-273505-pcsw3vmx 187 53 as as IN cord-273505-pcsw3vmx 187 54 the the DT cord-273505-pcsw3vmx 187 55 TLR-9 TLR-9 NNP cord-273505-pcsw3vmx 187 56 signaling signal VBG cord-273505-pcsw3vmx 187 57 cascade cascade NN cord-273505-pcsw3vmx 187 58 . . . cord-273505-pcsw3vmx 188 1 FcγRIIB FcγRIIB NNP cord-273505-pcsw3vmx 188 2 is be VBZ cord-273505-pcsw3vmx 188 3 the the DT cord-273505-pcsw3vmx 188 4 only only JJ cord-273505-pcsw3vmx 188 5 classical classical JJ cord-273505-pcsw3vmx 188 6 FcγR FcγR NNP cord-273505-pcsw3vmx 188 7 expressed express VBN cord-273505-pcsw3vmx 188 8 on on IN cord-273505-pcsw3vmx 188 9 B b NN cord-273505-pcsw3vmx 188 10 cells cell NNS cord-273505-pcsw3vmx 188 11 , , , cord-273505-pcsw3vmx 188 12 and and CC cord-273505-pcsw3vmx 188 13 its -PRON- PRP$ cord-273505-pcsw3vmx 188 14 elevated elevated JJ cord-273505-pcsw3vmx 188 15 expression expression NN cord-273505-pcsw3vmx 188 16 levels level NNS cord-273505-pcsw3vmx 188 17 after after IN cord-273505-pcsw3vmx 188 18 effective effective JJ cord-273505-pcsw3vmx 188 19 high high JJ cord-273505-pcsw3vmx 188 20 - - HYPH cord-273505-pcsw3vmx 188 21 dose dose NN cord-273505-pcsw3vmx 188 22 IVIg ivig NN cord-273505-pcsw3vmx 188 23 therapy therapy NN cord-273505-pcsw3vmx 188 24 may may MD cord-273505-pcsw3vmx 188 25 be be VB cord-273505-pcsw3vmx 188 26 involved involve VBN cord-273505-pcsw3vmx 188 27 in in IN cord-273505-pcsw3vmx 188 28 inhibitory inhibitory JJ cord-273505-pcsw3vmx 188 29 effects effect NNS cord-273505-pcsw3vmx 188 30 of of IN cord-273505-pcsw3vmx 188 31 IVIg ivig NN cord-273505-pcsw3vmx 188 32 on on IN cord-273505-pcsw3vmx 188 33 B b NN cord-273505-pcsw3vmx 188 34 cells cell NNS cord-273505-pcsw3vmx 188 35 ( ( -LRB- cord-273505-pcsw3vmx 188 36 61 61 CD cord-273505-pcsw3vmx 188 37 , , , cord-273505-pcsw3vmx 188 38 185 185 CD cord-273505-pcsw3vmx 188 39 , , , cord-273505-pcsw3vmx 188 40 186 186 CD cord-273505-pcsw3vmx 188 41 ) ) -RRB- cord-273505-pcsw3vmx 188 42 . . . cord-273505-pcsw3vmx 189 1 However however RB cord-273505-pcsw3vmx 189 2 , , , cord-273505-pcsw3vmx 189 3 IVIg ivig NN cord-273505-pcsw3vmx 189 4 - - HYPH cord-273505-pcsw3vmx 189 5 induced induce VBN cord-273505-pcsw3vmx 189 6 upregulation upregulation NN cord-273505-pcsw3vmx 189 7 of of IN cord-273505-pcsw3vmx 189 8 FcγRIIB fcγriib NN cord-273505-pcsw3vmx 189 9 in in IN cord-273505-pcsw3vmx 189 10 B b NN cord-273505-pcsw3vmx 189 11 cells cell NNS cord-273505-pcsw3vmx 189 12 is be VBZ cord-273505-pcsw3vmx 189 13 independent independent JJ cord-273505-pcsw3vmx 189 14 of of IN cord-273505-pcsw3vmx 189 15 classical classical JJ cord-273505-pcsw3vmx 189 16 FcγRIIB FcγRIIB NNP cord-273505-pcsw3vmx 189 17 signaling signal VBG cord-273505-pcsw3vmx 189 18 intermediates intermediate NNS cord-273505-pcsw3vmx 189 19 , , , cord-273505-pcsw3vmx 189 20 suggesting suggest VBG cord-273505-pcsw3vmx 189 21 that that IN cord-273505-pcsw3vmx 189 22 it -PRON- PRP cord-273505-pcsw3vmx 189 23 is be VBZ cord-273505-pcsw3vmx 189 24 likely likely RB cord-273505-pcsw3vmx 189 25 a a DT cord-273505-pcsw3vmx 189 26 consequence consequence NN cord-273505-pcsw3vmx 189 27 rather rather RB cord-273505-pcsw3vmx 189 28 than than IN cord-273505-pcsw3vmx 189 29 a a DT cord-273505-pcsw3vmx 189 30 cause cause NN cord-273505-pcsw3vmx 189 31 of of IN cord-273505-pcsw3vmx 189 32 high high JJ cord-273505-pcsw3vmx 189 33 - - HYPH cord-273505-pcsw3vmx 189 34 dose dose NN cord-273505-pcsw3vmx 189 35 IVIg ivig NN cord-273505-pcsw3vmx 189 36 therapy therapy NN cord-273505-pcsw3vmx 189 37 ( ( -LRB- cord-273505-pcsw3vmx 189 38 187 187 CD cord-273505-pcsw3vmx 189 39 , , , cord-273505-pcsw3vmx 189 40 188 188 CD cord-273505-pcsw3vmx 189 41 ) ) -RRB- cord-273505-pcsw3vmx 189 42 . . . cord-273505-pcsw3vmx 190 1 It -PRON- PRP cord-273505-pcsw3vmx 190 2 has have VBZ cord-273505-pcsw3vmx 190 3 been be VBN cord-273505-pcsw3vmx 190 4 proposed propose VBN cord-273505-pcsw3vmx 190 5 that that IN cord-273505-pcsw3vmx 190 6 sialylated sialylated JJ cord-273505-pcsw3vmx 190 7 IgG IgG NNP cord-273505-pcsw3vmx 190 8 binds bind VBZ cord-273505-pcsw3vmx 190 9 to to IN cord-273505-pcsw3vmx 190 10 DC DC NNP cord-273505-pcsw3vmx 190 11 - - HYPH cord-273505-pcsw3vmx 190 12 SIGN SIGN NNP cord-273505-pcsw3vmx 190 13 in in IN cord-273505-pcsw3vmx 190 14 addition addition NN cord-273505-pcsw3vmx 190 15 to to IN cord-273505-pcsw3vmx 190 16 CD23 CD23 NNP cord-273505-pcsw3vmx 190 17 , , , cord-273505-pcsw3vmx 190 18 a a DT cord-273505-pcsw3vmx 190 19 C c NN cord-273505-pcsw3vmx 190 20 - - HYPH cord-273505-pcsw3vmx 190 21 type type NN cord-273505-pcsw3vmx 190 22 lectin lectin NN cord-273505-pcsw3vmx 190 23 which which WDT cord-273505-pcsw3vmx 190 24 is be VBZ cord-273505-pcsw3vmx 190 25 also also RB cord-273505-pcsw3vmx 190 26 a a DT cord-273505-pcsw3vmx 190 27 known know VBN cord-273505-pcsw3vmx 190 28 low low JJ cord-273505-pcsw3vmx 190 29 - - HYPH cord-273505-pcsw3vmx 190 30 affinity affinity NN cord-273505-pcsw3vmx 190 31 IgE IgE NNP cord-273505-pcsw3vmx 190 32 receptor receptor NN cord-273505-pcsw3vmx 190 33 characteristically characteristically RB cord-273505-pcsw3vmx 190 34 expressed express VBN cord-273505-pcsw3vmx 190 35 on on IN cord-273505-pcsw3vmx 190 36 B b NN cord-273505-pcsw3vmx 190 37 cells cell NNS cord-273505-pcsw3vmx 190 38 , , , cord-273505-pcsw3vmx 190 39 inducing induce VBG cord-273505-pcsw3vmx 190 40 the the DT cord-273505-pcsw3vmx 190 41 suppression suppression NN cord-273505-pcsw3vmx 190 42 of of IN cord-273505-pcsw3vmx 190 43 B b NN cord-273505-pcsw3vmx 190 44 cells cell NNS cord-273505-pcsw3vmx 190 45 ( ( -LRB- cord-273505-pcsw3vmx 190 46 189 189 CD cord-273505-pcsw3vmx 190 47 ) ) -RRB- cord-273505-pcsw3vmx 190 48 . . . cord-273505-pcsw3vmx 191 1 However however RB cord-273505-pcsw3vmx 191 2 , , , cord-273505-pcsw3vmx 191 3 there there EX cord-273505-pcsw3vmx 191 4 has have VBZ cord-273505-pcsw3vmx 191 5 been be VBN cord-273505-pcsw3vmx 191 6 disagreement disagreement NN cord-273505-pcsw3vmx 191 7 as as IN cord-273505-pcsw3vmx 191 8 to to IN cord-273505-pcsw3vmx 191 9 whether whether IN cord-273505-pcsw3vmx 191 10 there there EX cord-273505-pcsw3vmx 191 11 is be VBZ cord-273505-pcsw3vmx 191 12 a a DT cord-273505-pcsw3vmx 191 13 direct direct JJ cord-273505-pcsw3vmx 191 14 interaction interaction NN cord-273505-pcsw3vmx 191 15 between between IN cord-273505-pcsw3vmx 191 16 IgG IgG NNP cord-273505-pcsw3vmx 191 17 and and CC cord-273505-pcsw3vmx 191 18 DC DC NNP cord-273505-pcsw3vmx 191 19 - - HYPH cord-273505-pcsw3vmx 191 20 SIGN SIGN NNP cord-273505-pcsw3vmx 191 21 / / SYM cord-273505-pcsw3vmx 191 22 CD23 CD23 NNP cord-273505-pcsw3vmx 191 23 ( ( -LRB- cord-273505-pcsw3vmx 191 24 67 67 CD cord-273505-pcsw3vmx 191 25 , , , cord-273505-pcsw3vmx 191 26 190 190 CD cord-273505-pcsw3vmx 191 27 ) ) -RRB- cord-273505-pcsw3vmx 191 28 . . . cord-273505-pcsw3vmx 192 1 A a DT cord-273505-pcsw3vmx 192 2 further further RB cord-273505-pcsw3vmx 192 3 proposed propose VBN cord-273505-pcsw3vmx 192 4 mechanism mechanism NN cord-273505-pcsw3vmx 192 5 of of IN cord-273505-pcsw3vmx 192 6 action action NN cord-273505-pcsw3vmx 192 7 of of IN cord-273505-pcsw3vmx 192 8 high high JJ cord-273505-pcsw3vmx 192 9 - - HYPH cord-273505-pcsw3vmx 192 10 dose dose NN cord-273505-pcsw3vmx 192 11 IVIg ivig NN cord-273505-pcsw3vmx 192 12 is be VBZ cord-273505-pcsw3vmx 192 13 the the DT cord-273505-pcsw3vmx 192 14 interaction interaction NN cord-273505-pcsw3vmx 192 15 between between IN cord-273505-pcsw3vmx 192 16 the the DT cord-273505-pcsw3vmx 192 17 sialylated sialylated JJ cord-273505-pcsw3vmx 192 18 Fc Fc NNP cord-273505-pcsw3vmx 192 19 fragment fragment NN cord-273505-pcsw3vmx 192 20 of of IN cord-273505-pcsw3vmx 192 21 IgG igg NN cord-273505-pcsw3vmx 192 22 and and CC cord-273505-pcsw3vmx 192 23 CD22 CD22 NNP cord-273505-pcsw3vmx 192 24 , , , cord-273505-pcsw3vmx 192 25 an an DT cord-273505-pcsw3vmx 192 26 I i NN cord-273505-pcsw3vmx 192 27 - - HYPH cord-273505-pcsw3vmx 192 28 type type NN cord-273505-pcsw3vmx 192 29 lectin lectin NN cord-273505-pcsw3vmx 192 30 expressed express VBN cord-273505-pcsw3vmx 192 31 on on IN cord-273505-pcsw3vmx 192 32 B b NN cord-273505-pcsw3vmx 192 33 cells cell NNS cord-273505-pcsw3vmx 192 34 , , , cord-273505-pcsw3vmx 192 35 which which WDT cord-273505-pcsw3vmx 192 36 results result VBZ cord-273505-pcsw3vmx 192 37 in in IN cord-273505-pcsw3vmx 192 38 the the DT cord-273505-pcsw3vmx 192 39 activation activation NN cord-273505-pcsw3vmx 192 40 of of IN cord-273505-pcsw3vmx 192 41 the the DT cord-273505-pcsw3vmx 192 42 ITIM ITIM NNP cord-273505-pcsw3vmx 192 43 signaling signal VBG cord-273505-pcsw3vmx 192 44 cascade cascade NN cord-273505-pcsw3vmx 192 45 , , , cord-273505-pcsw3vmx 192 46 subsequently subsequently RB cord-273505-pcsw3vmx 192 47 promoting promote VBG cord-273505-pcsw3vmx 192 48 B b NN cord-273505-pcsw3vmx 192 49 cell cell NN cord-273505-pcsw3vmx 192 50 apoptosis apoptosis NN cord-273505-pcsw3vmx 192 51 ( ( -LRB- cord-273505-pcsw3vmx 192 52 183 183 CD cord-273505-pcsw3vmx 192 53 , , , cord-273505-pcsw3vmx 192 54 191 191 CD cord-273505-pcsw3vmx 192 55 , , , cord-273505-pcsw3vmx 192 56 192 192 CD cord-273505-pcsw3vmx 192 57 ) ) -RRB- cord-273505-pcsw3vmx 192 58 . . . cord-273505-pcsw3vmx 193 1 Except except IN cord-273505-pcsw3vmx 193 2 for for IN cord-273505-pcsw3vmx 193 3 FcRs FcRs NNP cord-273505-pcsw3vmx 193 4 , , , cord-273505-pcsw3vmx 193 5 the the DT cord-273505-pcsw3vmx 193 6 TLR-9 TLR-9 NNP cord-273505-pcsw3vmx 193 7 signaling signal VBG cord-273505-pcsw3vmx 193 8 cascade cascade NN cord-273505-pcsw3vmx 193 9 may may MD cord-273505-pcsw3vmx 193 10 also also RB cord-273505-pcsw3vmx 193 11 be be VB cord-273505-pcsw3vmx 193 12 involved involve VBN cord-273505-pcsw3vmx 193 13 in in IN cord-273505-pcsw3vmx 193 14 inhibitory inhibitory JJ cord-273505-pcsw3vmx 193 15 effects effect NNS cord-273505-pcsw3vmx 193 16 . . . cord-273505-pcsw3vmx 194 1 IVIg IVIg NNP cord-273505-pcsw3vmx 194 2 could could MD cord-273505-pcsw3vmx 194 3 mimic mimic VB cord-273505-pcsw3vmx 194 4 the the DT cord-273505-pcsw3vmx 194 5 effects effect NNS cord-273505-pcsw3vmx 194 6 of of IN cord-273505-pcsw3vmx 194 7 MyD88 myd88 JJ cord-273505-pcsw3vmx 194 8 inhibitors inhibitor NNS cord-273505-pcsw3vmx 194 9 and and CC cord-273505-pcsw3vmx 194 10 result result VB cord-273505-pcsw3vmx 194 11 in in IN cord-273505-pcsw3vmx 194 12 the the DT cord-273505-pcsw3vmx 194 13 suppression suppression NN cord-273505-pcsw3vmx 194 14 of of IN cord-273505-pcsw3vmx 194 15 the the DT cord-273505-pcsw3vmx 194 16 TLR TLR NNP cord-273505-pcsw3vmx 194 17 - - HYPH cord-273505-pcsw3vmx 194 18 induced induce VBN cord-273505-pcsw3vmx 194 19 NF nf NN cord-273505-pcsw3vmx 194 20 - - HYPH cord-273505-pcsw3vmx 194 21 κB κB NNP cord-273505-pcsw3vmx 194 22 signaling signal VBG cord-273505-pcsw3vmx 194 23 pathway pathway NN cord-273505-pcsw3vmx 194 24 and and CC cord-273505-pcsw3vmx 194 25 downstream downstream JJ cord-273505-pcsw3vmx 194 26 production production NN cord-273505-pcsw3vmx 194 27 of of IN cord-273505-pcsw3vmx 194 28 cytokines cytokine NNS cord-273505-pcsw3vmx 194 29 ( ( -LRB- cord-273505-pcsw3vmx 194 30 193 193 CD cord-273505-pcsw3vmx 194 31 , , , cord-273505-pcsw3vmx 194 32 194 194 CD cord-273505-pcsw3vmx 194 33 ) ) -RRB- cord-273505-pcsw3vmx 194 34 . . . cord-273505-pcsw3vmx 195 1 A a DT cord-273505-pcsw3vmx 195 2 " " `` cord-273505-pcsw3vmx 195 3 paradoxical paradoxical JJ cord-273505-pcsw3vmx 195 4 " " '' cord-273505-pcsw3vmx 195 5 phenomenon phenomenon NN cord-273505-pcsw3vmx 195 6 has have VBZ cord-273505-pcsw3vmx 195 7 been be VBN cord-273505-pcsw3vmx 195 8 observed observe VBN cord-273505-pcsw3vmx 195 9 , , , cord-273505-pcsw3vmx 195 10 where where WRB cord-273505-pcsw3vmx 195 11 large large JJ cord-273505-pcsw3vmx 195 12 amounts amount NNS cord-273505-pcsw3vmx 195 13 of of IN cord-273505-pcsw3vmx 195 14 immature immature JJ cord-273505-pcsw3vmx 195 15 plasma plasma NN cord-273505-pcsw3vmx 195 16 cells cell NNS cord-273505-pcsw3vmx 195 17 were be VBD cord-273505-pcsw3vmx 195 18 mobilized mobilize VBN cord-273505-pcsw3vmx 195 19 after after IN cord-273505-pcsw3vmx 195 20 high high JJ cord-273505-pcsw3vmx 195 21 - - HYPH cord-273505-pcsw3vmx 195 22 dose dose NN cord-273505-pcsw3vmx 195 23 IVIg ivig NN cord-273505-pcsw3vmx 195 24 therapy therapy NN cord-273505-pcsw3vmx 195 25 in in IN cord-273505-pcsw3vmx 195 26 patients patient NNS cord-273505-pcsw3vmx 195 27 with with IN cord-273505-pcsw3vmx 195 28 autoimmune autoimmune JJ cord-273505-pcsw3vmx 195 29 diseases disease NNS cord-273505-pcsw3vmx 195 30 , , , cord-273505-pcsw3vmx 195 31 suggesting suggest VBG cord-273505-pcsw3vmx 195 32 de de IN cord-273505-pcsw3vmx 195 33 novo novo NNP cord-273505-pcsw3vmx 195 34 B B NNP cord-273505-pcsw3vmx 195 35 cell cell NN cord-273505-pcsw3vmx 195 36 activation activation NN cord-273505-pcsw3vmx 195 37 . . . cord-273505-pcsw3vmx 196 1 This this DT cord-273505-pcsw3vmx 196 2 is be VBZ cord-273505-pcsw3vmx 196 3 consistent consistent JJ cord-273505-pcsw3vmx 196 4 with with IN cord-273505-pcsw3vmx 196 5 the the DT cord-273505-pcsw3vmx 196 6 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 196 7 functions function NNS cord-273505-pcsw3vmx 196 8 of of IN cord-273505-pcsw3vmx 196 9 IVIg IVIg NNP cord-273505-pcsw3vmx 196 10 at at IN cord-273505-pcsw3vmx 196 11 low low JJ cord-273505-pcsw3vmx 196 12 doses dose NNS cord-273505-pcsw3vmx 196 13 ( ( -LRB- cord-273505-pcsw3vmx 196 14 184 184 CD cord-273505-pcsw3vmx 196 15 , , , cord-273505-pcsw3vmx 196 16 195 195 CD cord-273505-pcsw3vmx 196 17 , , , cord-273505-pcsw3vmx 196 18 196 196 CD cord-273505-pcsw3vmx 196 19 ) ) -RRB- cord-273505-pcsw3vmx 196 20 . . . cord-273505-pcsw3vmx 197 1 Although although IN cord-273505-pcsw3vmx 197 2 the the DT cord-273505-pcsw3vmx 197 3 potential potential JJ cord-273505-pcsw3vmx 197 4 roles role NNS cord-273505-pcsw3vmx 197 5 of of IN cord-273505-pcsw3vmx 197 6 plasma plasma NN cord-273505-pcsw3vmx 197 7 blasts blast NNS cord-273505-pcsw3vmx 197 8 under under IN cord-273505-pcsw3vmx 197 9 different different JJ cord-273505-pcsw3vmx 197 10 disease disease NN cord-273505-pcsw3vmx 197 11 conditions condition NNS cord-273505-pcsw3vmx 197 12 remain remain VBP cord-273505-pcsw3vmx 197 13 unclear unclear JJ cord-273505-pcsw3vmx 197 14 , , , cord-273505-pcsw3vmx 197 15 this this DT cord-273505-pcsw3vmx 197 16 phenomenon phenomenon NN cord-273505-pcsw3vmx 197 17 highlights highlight VBZ cord-273505-pcsw3vmx 197 18 binary binary JJ cord-273505-pcsw3vmx 197 19 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 197 20 effects effect NNS cord-273505-pcsw3vmx 197 21 of of IN cord-273505-pcsw3vmx 197 22 high high JJ cord-273505-pcsw3vmx 197 23 - - HYPH cord-273505-pcsw3vmx 197 24 dose dose NN cord-273505-pcsw3vmx 197 25 IVIg ivig NN cord-273505-pcsw3vmx 197 26 to to IN cord-273505-pcsw3vmx 197 27 humoral humoral JJ cord-273505-pcsw3vmx 197 28 immunity immunity NN cord-273505-pcsw3vmx 197 29 . . . cord-273505-pcsw3vmx 198 1 To to TO cord-273505-pcsw3vmx 198 2 summarize summarize VB cord-273505-pcsw3vmx 198 3 , , , cord-273505-pcsw3vmx 198 4 the the DT cord-273505-pcsw3vmx 198 5 cytokine cytokine NN cord-273505-pcsw3vmx 198 6 storm storm NN cord-273505-pcsw3vmx 198 7 observed observe VBD cord-273505-pcsw3vmx 198 8 during during IN cord-273505-pcsw3vmx 198 9 severe severe JJ cord-273505-pcsw3vmx 198 10 viral viral JJ cord-273505-pcsw3vmx 198 11 infection infection NN cord-273505-pcsw3vmx 198 12 is be VBZ cord-273505-pcsw3vmx 198 13 associated associate VBN cord-273505-pcsw3vmx 198 14 with with IN cord-273505-pcsw3vmx 198 15 various various JJ cord-273505-pcsw3vmx 198 16 immune immune JJ cord-273505-pcsw3vmx 198 17 dysfunctions dysfunction NNS cord-273505-pcsw3vmx 198 18 . . . cord-273505-pcsw3vmx 199 1 Several several JJ cord-273505-pcsw3vmx 199 2 therapeutic therapeutic JJ cord-273505-pcsw3vmx 199 3 interventions intervention NNS cord-273505-pcsw3vmx 199 4 targeting target VBG cord-273505-pcsw3vmx 199 5 the the DT cord-273505-pcsw3vmx 199 6 host host NN cord-273505-pcsw3vmx 199 7 immune immune JJ cord-273505-pcsw3vmx 199 8 response response NN cord-273505-pcsw3vmx 199 9 have have VBP cord-273505-pcsw3vmx 199 10 been be VBN cord-273505-pcsw3vmx 199 11 attempted attempt VBN cord-273505-pcsw3vmx 199 12 . . . cord-273505-pcsw3vmx 200 1 Although although IN cord-273505-pcsw3vmx 200 2 the the DT cord-273505-pcsw3vmx 200 3 proposed propose VBN cord-273505-pcsw3vmx 200 4 mechanisms mechanism NNS cord-273505-pcsw3vmx 200 5 of of IN cord-273505-pcsw3vmx 200 6 high high JJ cord-273505-pcsw3vmx 200 7 - - HYPH cord-273505-pcsw3vmx 200 8 dose dose NN cord-273505-pcsw3vmx 200 9 IVIg ivig NN cord-273505-pcsw3vmx 200 10 on on IN cord-273505-pcsw3vmx 200 11 the the DT cord-273505-pcsw3vmx 200 12 modulation modulation NN cord-273505-pcsw3vmx 200 13 immune immune JJ cord-273505-pcsw3vmx 200 14 cells cell NNS cord-273505-pcsw3vmx 200 15 and and CC cord-273505-pcsw3vmx 200 16 cytokine cytokine NN cord-273505-pcsw3vmx 200 17 cascades cascade NNS cord-273505-pcsw3vmx 200 18 are be VBP cord-273505-pcsw3vmx 200 19 mainly mainly RB cord-273505-pcsw3vmx 200 20 derived derive VBN cord-273505-pcsw3vmx 200 21 from from IN cord-273505-pcsw3vmx 200 22 research research NN cord-273505-pcsw3vmx 200 23 into into IN cord-273505-pcsw3vmx 200 24 autoimmune autoimmune JJ cord-273505-pcsw3vmx 200 25 diseases disease NNS cord-273505-pcsw3vmx 200 26 , , , cord-273505-pcsw3vmx 200 27 its -PRON- PRP$ cord-273505-pcsw3vmx 200 28 use use NN cord-273505-pcsw3vmx 200 29 in in IN cord-273505-pcsw3vmx 200 30 reversing reverse VBG cord-273505-pcsw3vmx 200 31 a a DT cord-273505-pcsw3vmx 200 32 cytokine cytokine NN cord-273505-pcsw3vmx 200 33 storm storm NN cord-273505-pcsw3vmx 200 34 , , , cord-273505-pcsw3vmx 200 35 in in IN cord-273505-pcsw3vmx 200 36 addition addition NN cord-273505-pcsw3vmx 200 37 to to IN cord-273505-pcsw3vmx 200 38 providing provide VBG cord-273505-pcsw3vmx 200 39 passive passive JJ cord-273505-pcsw3vmx 200 40 immunity immunity NN cord-273505-pcsw3vmx 200 41 during during IN cord-273505-pcsw3vmx 200 42 severe severe JJ cord-273505-pcsw3vmx 200 43 viral viral JJ cord-273505-pcsw3vmx 200 44 infection infection NN cord-273505-pcsw3vmx 200 45 , , , cord-273505-pcsw3vmx 200 46 is be VBZ cord-273505-pcsw3vmx 200 47 supported support VBN cord-273505-pcsw3vmx 200 48 by by IN cord-273505-pcsw3vmx 200 49 recent recent JJ cord-273505-pcsw3vmx 200 50 evidence evidence NN cord-273505-pcsw3vmx 200 51 . . . cord-273505-pcsw3vmx 201 1 The the DT cord-273505-pcsw3vmx 201 2 humoral humoral JJ cord-273505-pcsw3vmx 201 3 immune immune JJ cord-273505-pcsw3vmx 201 4 response response NN cord-273505-pcsw3vmx 201 5 to to IN cord-273505-pcsw3vmx 201 6 invading invade VBG cord-273505-pcsw3vmx 201 7 pathogens pathogen NNS cord-273505-pcsw3vmx 201 8 by by IN cord-273505-pcsw3vmx 201 9 producing produce VBG cord-273505-pcsw3vmx 201 10 neutralizing neutralize VBG cord-273505-pcsw3vmx 201 11 antibodies antibody NNS cord-273505-pcsw3vmx 201 12 is be VBZ cord-273505-pcsw3vmx 201 13 crucial crucial JJ cord-273505-pcsw3vmx 201 14 in in IN cord-273505-pcsw3vmx 201 15 the the DT cord-273505-pcsw3vmx 201 16 host host NN cord-273505-pcsw3vmx 201 17 adaptive adaptive JJ cord-273505-pcsw3vmx 201 18 immune immune JJ cord-273505-pcsw3vmx 201 19 system system NN cord-273505-pcsw3vmx 201 20 . . . cord-273505-pcsw3vmx 202 1 Paradoxically paradoxically RB cord-273505-pcsw3vmx 202 2 , , , cord-273505-pcsw3vmx 202 3 antibodies antibody NNS cord-273505-pcsw3vmx 202 4 may may MD cord-273505-pcsw3vmx 202 5 provide provide VB cord-273505-pcsw3vmx 202 6 an an DT cord-273505-pcsw3vmx 202 7 attractive attractive JJ cord-273505-pcsw3vmx 202 8 means mean NNS cord-273505-pcsw3vmx 202 9 for for IN cord-273505-pcsw3vmx 202 10 a a DT cord-273505-pcsw3vmx 202 11 variety variety NN cord-273505-pcsw3vmx 202 12 of of IN cord-273505-pcsw3vmx 202 13 viruses virus NNS cord-273505-pcsw3vmx 202 14 to to TO cord-273505-pcsw3vmx 202 15 enhance enhance VB cord-273505-pcsw3vmx 202 16 viral viral JJ cord-273505-pcsw3vmx 202 17 entry entry NN cord-273505-pcsw3vmx 202 18 and and CC cord-273505-pcsw3vmx 202 19 replication replication NN cord-273505-pcsw3vmx 202 20 in in IN cord-273505-pcsw3vmx 202 21 some some DT cord-273505-pcsw3vmx 202 22 cell cell NN cord-273505-pcsw3vmx 202 23 types type NNS cord-273505-pcsw3vmx 202 24 under under IN cord-273505-pcsw3vmx 202 25 certain certain JJ cord-273505-pcsw3vmx 202 26 conditions condition NNS cord-273505-pcsw3vmx 202 27 . . . cord-273505-pcsw3vmx 203 1 The the DT cord-273505-pcsw3vmx 203 2 unique unique JJ cord-273505-pcsw3vmx 203 3 phenomenon phenomenon NN cord-273505-pcsw3vmx 203 4 that that IN cord-273505-pcsw3vmx 203 5 preexisting preexist VBG cord-273505-pcsw3vmx 203 6 poor poor JJ cord-273505-pcsw3vmx 203 7 neutralizing neutralize VBG cord-273505-pcsw3vmx 203 8 antibodies antibody NNS cord-273505-pcsw3vmx 203 9 facilitate facilitate VBP cord-273505-pcsw3vmx 203 10 viral viral JJ cord-273505-pcsw3vmx 203 11 access access NN cord-273505-pcsw3vmx 203 12 to to IN cord-273505-pcsw3vmx 203 13 FcγRs FcγRs NNP cord-273505-pcsw3vmx 203 14 and and CC cord-273505-pcsw3vmx 203 15 lead lead VB cord-273505-pcsw3vmx 203 16 to to IN cord-273505-pcsw3vmx 203 17 enhanced enhance VBN cord-273505-pcsw3vmx 203 18 infection infection NN cord-273505-pcsw3vmx 203 19 or or CC cord-273505-pcsw3vmx 203 20 immunopathology immunopathology NN cord-273505-pcsw3vmx 203 21 is be VBZ cord-273505-pcsw3vmx 203 22 also also RB cord-273505-pcsw3vmx 203 23 referred refer VBN cord-273505-pcsw3vmx 203 24 to to IN cord-273505-pcsw3vmx 203 25 as as IN cord-273505-pcsw3vmx 203 26 antibodydependent antibodydependent NN cord-273505-pcsw3vmx 203 27 enhancement enhancement NN cord-273505-pcsw3vmx 203 28 ( ( -LRB- cord-273505-pcsw3vmx 203 29 ADE ADE NNP cord-273505-pcsw3vmx 203 30 ) ) -RRB- cord-273505-pcsw3vmx 203 31 . . . cord-273505-pcsw3vmx 204 1 ADE ADE NNP cord-273505-pcsw3vmx 204 2 has have VBZ cord-273505-pcsw3vmx 204 3 been be VBN cord-273505-pcsw3vmx 204 4 implicated implicate VBN cord-273505-pcsw3vmx 204 5 widely widely RB cord-273505-pcsw3vmx 204 6 in in IN cord-273505-pcsw3vmx 204 7 flavivirus flavivirus JJ cord-273505-pcsw3vmx 204 8 infections infection NNS cord-273505-pcsw3vmx 204 9 , , , cord-273505-pcsw3vmx 204 10 such such JJ cord-273505-pcsw3vmx 204 11 as as IN cord-273505-pcsw3vmx 204 12 WNV WNV NNP cord-273505-pcsw3vmx 204 13 and and CC cord-273505-pcsw3vmx 204 14 DENV DENV NNP cord-273505-pcsw3vmx 204 15 , , , cord-273505-pcsw3vmx 204 16 and and CC cord-273505-pcsw3vmx 204 17 highdose highdose NN cord-273505-pcsw3vmx 204 18 IVIg IVIg NNP cord-273505-pcsw3vmx 204 19 is be VBZ cord-273505-pcsw3vmx 204 20 commonly commonly RB cord-273505-pcsw3vmx 204 21 used use VBN cord-273505-pcsw3vmx 204 22 in in IN cord-273505-pcsw3vmx 204 23 treating treat VBG cord-273505-pcsw3vmx 204 24 WNV WNV NNP cord-273505-pcsw3vmx 204 25 encephalitis encephalitis RB cord-273505-pcsw3vmx 204 26 with with IN cord-273505-pcsw3vmx 204 27 satisfactory satisfactory JJ cord-273505-pcsw3vmx 204 28 effect effect NN cord-273505-pcsw3vmx 204 29 . . . cord-273505-pcsw3vmx 205 1 However however RB cord-273505-pcsw3vmx 205 2 , , , cord-273505-pcsw3vmx 205 3 little little JJ cord-273505-pcsw3vmx 205 4 is be VBZ cord-273505-pcsw3vmx 205 5 known know VBN cord-273505-pcsw3vmx 205 6 about about IN cord-273505-pcsw3vmx 205 7 ADE ADE NNP cord-273505-pcsw3vmx 205 8 in in IN cord-273505-pcsw3vmx 205 9 respiratory respiratory JJ cord-273505-pcsw3vmx 205 10 virus virus NN cord-273505-pcsw3vmx 205 11 infection infection NN cord-273505-pcsw3vmx 205 12 ( ( -LRB- cord-273505-pcsw3vmx 205 13 197 197 CD cord-273505-pcsw3vmx 205 14 ) ) -RRB- cord-273505-pcsw3vmx 205 15 ( ( -LRB- cord-273505-pcsw3vmx 205 16 198 198 CD cord-273505-pcsw3vmx 205 17 ) ) -RRB- cord-273505-pcsw3vmx 205 18 ( ( -LRB- cord-273505-pcsw3vmx 205 19 199 199 CD cord-273505-pcsw3vmx 205 20 ) ) -RRB- cord-273505-pcsw3vmx 205 21 . . . cord-273505-pcsw3vmx 206 1 ADE ADE NNP cord-273505-pcsw3vmx 206 2 is be VBZ cord-273505-pcsw3vmx 206 3 currently currently RB cord-273505-pcsw3vmx 206 4 being be VBG cord-273505-pcsw3vmx 206 5 considered consider VBN cord-273505-pcsw3vmx 206 6 as as IN cord-273505-pcsw3vmx 206 7 a a DT cord-273505-pcsw3vmx 206 8 potential potential JJ cord-273505-pcsw3vmx 206 9 contributor contributor NN cord-273505-pcsw3vmx 206 10 to to IN cord-273505-pcsw3vmx 206 11 the the DT cord-273505-pcsw3vmx 206 12 immunopathology immunopathology NN cord-273505-pcsw3vmx 206 13 of of IN cord-273505-pcsw3vmx 206 14 SARS SARS NNP cord-273505-pcsw3vmx 206 15 . . . cord-273505-pcsw3vmx 207 1 People People NNS cord-273505-pcsw3vmx 207 2 who who WP cord-273505-pcsw3vmx 207 3 succumbed succumb VBD cord-273505-pcsw3vmx 207 4 to to IN cord-273505-pcsw3vmx 207 5 SARS SARS NNP cord-273505-pcsw3vmx 207 6 had have VBD cord-273505-pcsw3vmx 207 7 significantly significantly RB cord-273505-pcsw3vmx 207 8 higher high JJR cord-273505-pcsw3vmx 207 9 S S NNP cord-273505-pcsw3vmx 207 10 glycoprotein glycoprotein NN cord-273505-pcsw3vmx 207 11 - - HYPH cord-273505-pcsw3vmx 207 12 specific specific JJ cord-273505-pcsw3vmx 207 13 neutralizing neutralize VBG cord-273505-pcsw3vmx 207 14 antibodies antibody NNS cord-273505-pcsw3vmx 207 15 in in IN cord-273505-pcsw3vmx 207 16 serum serum NN cord-273505-pcsw3vmx 207 17 during during IN cord-273505-pcsw3vmx 207 18 the the DT cord-273505-pcsw3vmx 207 19 early early JJ cord-273505-pcsw3vmx 207 20 stage stage NN cord-273505-pcsw3vmx 207 21 of of IN cord-273505-pcsw3vmx 207 22 infection infection NN cord-273505-pcsw3vmx 207 23 , , , cord-273505-pcsw3vmx 207 24 indicating indicate VBG cord-273505-pcsw3vmx 207 25 the the DT cord-273505-pcsw3vmx 207 26 possible possible JJ cord-273505-pcsw3vmx 207 27 presence presence NN cord-273505-pcsw3vmx 207 28 of of IN cord-273505-pcsw3vmx 207 29 ADE ADE NNP cord-273505-pcsw3vmx 207 30 ( ( -LRB- cord-273505-pcsw3vmx 207 31 200 200 CD cord-273505-pcsw3vmx 207 32 ) ) -RRB- cord-273505-pcsw3vmx 207 33 . . . cord-273505-pcsw3vmx 208 1 Similarly similarly RB cord-273505-pcsw3vmx 208 2 , , , cord-273505-pcsw3vmx 208 3 recent recent JJ cord-273505-pcsw3vmx 208 4 results result NNS cord-273505-pcsw3vmx 208 5 in in IN cord-273505-pcsw3vmx 208 6 SARS SARS NNP cord-273505-pcsw3vmx 208 7 - - HYPH cord-273505-pcsw3vmx 208 8 CoV CoV NNP cord-273505-pcsw3vmx 208 9 - - HYPH cord-273505-pcsw3vmx 208 10 infected infect VBN cord-273505-pcsw3vmx 208 11 Chinese chinese JJ cord-273505-pcsw3vmx 208 12 rhesus rhesu NNS cord-273505-pcsw3vmx 208 13 macaques macaque NNS cord-273505-pcsw3vmx 208 14 consistently consistently RB cord-273505-pcsw3vmx 208 15 showed show VBD cord-273505-pcsw3vmx 208 16 that that IN cord-273505-pcsw3vmx 208 17 anti anti JJ cord-273505-pcsw3vmx 208 18 - - JJ cord-273505-pcsw3vmx 208 19 spike spike JJ cord-273505-pcsw3vmx 208 20 IgG igg NN cord-273505-pcsw3vmx 208 21 significantly significantly RB cord-273505-pcsw3vmx 208 22 amplified amplify VBD cord-273505-pcsw3vmx 208 23 pro pro JJ cord-273505-pcsw3vmx 208 24 - - JJ cord-273505-pcsw3vmx 208 25 inflammatory inflammatory JJ cord-273505-pcsw3vmx 208 26 cytokine cytokine NN cord-273505-pcsw3vmx 208 27 production production NN cord-273505-pcsw3vmx 208 28 in in IN cord-273505-pcsw3vmx 208 29 activated activate VBN cord-273505-pcsw3vmx 208 30 macrophages macrophage NNS cord-273505-pcsw3vmx 208 31 and and CC cord-273505-pcsw3vmx 208 32 enhanced enhanced JJ cord-273505-pcsw3vmx 208 33 pulmonary pulmonary JJ cord-273505-pcsw3vmx 208 34 pathology pathology NN cord-273505-pcsw3vmx 208 35 . . . cord-273505-pcsw3vmx 209 1 These these DT cord-273505-pcsw3vmx 209 2 effects effect NNS cord-273505-pcsw3vmx 209 3 could could MD cord-273505-pcsw3vmx 209 4 be be VB cord-273505-pcsw3vmx 209 5 reduced reduce VBN cord-273505-pcsw3vmx 209 6 by by IN cord-273505-pcsw3vmx 209 7 the the DT cord-273505-pcsw3vmx 209 8 FcγRII FcγRII NNP cord-273505-pcsw3vmx 209 9 blocking block VBG cord-273505-pcsw3vmx 209 10 antibody antibody NN cord-273505-pcsw3vmx 209 11 ( ( -LRB- cord-273505-pcsw3vmx 209 12 110 110 CD cord-273505-pcsw3vmx 209 13 ) ) -RRB- cord-273505-pcsw3vmx 209 14 . . . cord-273505-pcsw3vmx 210 1 Similarly similarly RB cord-273505-pcsw3vmx 210 2 , , , cord-273505-pcsw3vmx 210 3 it -PRON- PRP cord-273505-pcsw3vmx 210 4 has have VBZ cord-273505-pcsw3vmx 210 5 been be VBN cord-273505-pcsw3vmx 210 6 shown show VBN cord-273505-pcsw3vmx 210 7 that that IN cord-273505-pcsw3vmx 210 8 infection infection NN cord-273505-pcsw3vmx 210 9 of of IN cord-273505-pcsw3vmx 210 10 macrophages macrophage NNS cord-273505-pcsw3vmx 210 11 is be VBZ cord-273505-pcsw3vmx 210 12 enhanced enhance VBN cord-273505-pcsw3vmx 210 13 by by IN cord-273505-pcsw3vmx 210 14 anti anti JJ cord-273505-pcsw3vmx 210 15 - - JJ cord-273505-pcsw3vmx 210 16 SARS SARS NNP cord-273505-pcsw3vmx 210 17 - - HYPH cord-273505-pcsw3vmx 210 18 CoV CoV NNP cord-273505-pcsw3vmx 210 19 spike spike NN cord-273505-pcsw3vmx 210 20 immune immune JJ cord-273505-pcsw3vmx 210 21 serum serum NN cord-273505-pcsw3vmx 210 22 but but CC cord-273505-pcsw3vmx 210 23 eliminated eliminate VBN cord-273505-pcsw3vmx 210 24 by by IN cord-273505-pcsw3vmx 210 25 the the DT cord-273505-pcsw3vmx 210 26 FcγRII FcγRII NNP cord-273505-pcsw3vmx 210 27 antibody antibody NN cord-273505-pcsw3vmx 210 28 , , , cord-273505-pcsw3vmx 210 29 suggesting suggest VBG cord-273505-pcsw3vmx 210 30 an an DT cord-273505-pcsw3vmx 210 31 FcγRII fcγrii JJ cord-273505-pcsw3vmx 210 32 - - HYPH cord-273505-pcsw3vmx 210 33 dependent dependent JJ cord-273505-pcsw3vmx 210 34 ADE ade NN cord-273505-pcsw3vmx 210 35 of of IN cord-273505-pcsw3vmx 210 36 SARS SARS NNP cord-273505-pcsw3vmx 210 37 - - HYPH cord-273505-pcsw3vmx 210 38 CoV CoV NNP cord-273505-pcsw3vmx 210 39 ( ( -LRB- cord-273505-pcsw3vmx 210 40 201 201 CD cord-273505-pcsw3vmx 210 41 ) ) -RRB- cord-273505-pcsw3vmx 210 42 . . . cord-273505-pcsw3vmx 211 1 Molecular molecular JJ cord-273505-pcsw3vmx 211 2 signaling signal VBG cord-273505-pcsw3vmx 211 3 analyses analysis NNS cord-273505-pcsw3vmx 211 4 investigating investigate VBG cord-273505-pcsw3vmx 211 5 FcγRIImediated fcγriimediated JJ cord-273505-pcsw3vmx 211 6 infection infection NN cord-273505-pcsw3vmx 211 7 by by IN cord-273505-pcsw3vmx 211 8 SARS SARS NNP cord-273505-pcsw3vmx 211 9 - - HYPH cord-273505-pcsw3vmx 211 10 CoV CoV NNP cord-273505-pcsw3vmx 212 1 revealed reveal VBD cord-273505-pcsw3vmx 212 2 that that IN cord-273505-pcsw3vmx 212 3 an an DT cord-273505-pcsw3vmx 212 4 intact intact JJ cord-273505-pcsw3vmx 212 5 cytosolic cytosolic JJ cord-273505-pcsw3vmx 212 6 domain domain NN cord-273505-pcsw3vmx 212 7 of of IN cord-273505-pcsw3vmx 212 8 FcγR FcγR NNP cord-273505-pcsw3vmx 212 9 was be VBD cord-273505-pcsw3vmx 212 10 required require VBN cord-273505-pcsw3vmx 212 11 , , , cord-273505-pcsw3vmx 212 12 and and CC cord-273505-pcsw3vmx 212 13 FcγRIIA FcγRIIA NNP cord-273505-pcsw3vmx 212 14 was be VBD cord-273505-pcsw3vmx 212 15 more more RBR cord-273505-pcsw3vmx 212 16 prone prone JJ cord-273505-pcsw3vmx 212 17 to to IN cord-273505-pcsw3vmx 212 18 ADE ADE NNP cord-273505-pcsw3vmx 212 19 than than IN cord-273505-pcsw3vmx 212 20 FcγRIIB FcγRIIB NNP cord-273505-pcsw3vmx 212 21 ( ( -LRB- cord-273505-pcsw3vmx 212 22 202 202 CD cord-273505-pcsw3vmx 212 23 ) ) -RRB- cord-273505-pcsw3vmx 212 24 . . . cord-273505-pcsw3vmx 213 1 Although although IN cord-273505-pcsw3vmx 213 2 in in IN cord-273505-pcsw3vmx 213 3 vivo vivo NN cord-273505-pcsw3vmx 213 4 evidence evidence NN cord-273505-pcsw3vmx 213 5 of of IN cord-273505-pcsw3vmx 213 6 ADE ADE NNP cord-273505-pcsw3vmx 213 7 in in IN cord-273505-pcsw3vmx 213 8 MERS MERS NNP cord-273505-pcsw3vmx 213 9 is be VBZ cord-273505-pcsw3vmx 213 10 lacking lack VBG cord-273505-pcsw3vmx 213 11 , , , cord-273505-pcsw3vmx 213 12 it -PRON- PRP cord-273505-pcsw3vmx 213 13 has have VBZ cord-273505-pcsw3vmx 213 14 been be VBN cord-273505-pcsw3vmx 213 15 shown show VBN cord-273505-pcsw3vmx 213 16 that that IN cord-273505-pcsw3vmx 213 17 MERS MERS NNP cord-273505-pcsw3vmx 213 18 - - HYPH cord-273505-pcsw3vmx 213 19 CoV cov NN cord-273505-pcsw3vmx 213 20 infections infection NNS cord-273505-pcsw3vmx 213 21 depended depend VBD cord-273505-pcsw3vmx 213 22 on on IN cord-273505-pcsw3vmx 213 23 monoclonal monoclonal JJ cord-273505-pcsw3vmx 213 24 antibody antibody NN cord-273505-pcsw3vmx 213 25 ( ( -LRB- cord-273505-pcsw3vmx 213 26 MAb MAb NNS cord-273505-pcsw3vmx 213 27 ) ) -RRB- cord-273505-pcsw3vmx 213 28 concentration concentration NN cord-273505-pcsw3vmx 213 29 , , , cord-273505-pcsw3vmx 213 30 binding bind VBG cord-273505-pcsw3vmx 213 31 affinity affinity NN cord-273505-pcsw3vmx 213 32 of of IN cord-273505-pcsw3vmx 213 33 MAb MAb NNS cord-273505-pcsw3vmx 213 34 for for IN cord-273505-pcsw3vmx 213 35 the the DT cord-273505-pcsw3vmx 213 36 viral viral JJ cord-273505-pcsw3vmx 213 37 receptor receptor NN cord-273505-pcsw3vmx 213 38 DPP4 DPP4 NNP cord-273505-pcsw3vmx 213 39 , , , cord-273505-pcsw3vmx 213 40 and and CC cord-273505-pcsw3vmx 213 41 tissue tissue NN cord-273505-pcsw3vmx 213 42 expressions expression NNS cord-273505-pcsw3vmx 213 43 of of IN cord-273505-pcsw3vmx 213 44 DPP4 DPP4 NNP cord-273505-pcsw3vmx 213 45 and and CC cord-273505-pcsw3vmx 213 46 FcγR FcγR NNP cord-273505-pcsw3vmx 213 47 , , , cord-273505-pcsw3vmx 213 48 providing provide VBG cord-273505-pcsw3vmx 213 49 a a DT cord-273505-pcsw3vmx 213 50 molecular molecular JJ cord-273505-pcsw3vmx 213 51 basis basis NN cord-273505-pcsw3vmx 213 52 of of IN cord-273505-pcsw3vmx 213 53 ADE ADE NNP cord-273505-pcsw3vmx 213 54 in in IN cord-273505-pcsw3vmx 213 55 MERS MERS NNP cord-273505-pcsw3vmx 213 56 - - HYPH cord-273505-pcsw3vmx 213 57 CoV CoV NNP cord-273505-pcsw3vmx 213 58 ( ( -LRB- cord-273505-pcsw3vmx 213 59 203 203 CD cord-273505-pcsw3vmx 213 60 ) ) -RRB- cord-273505-pcsw3vmx 213 61 . . . cord-273505-pcsw3vmx 214 1 Likewise likewise RB cord-273505-pcsw3vmx 214 2 , , , cord-273505-pcsw3vmx 214 3 the the DT cord-273505-pcsw3vmx 214 4 presence presence NN cord-273505-pcsw3vmx 214 5 of of IN cord-273505-pcsw3vmx 214 6 sub sub NN cord-273505-pcsw3vmx 214 7 - - JJ cord-273505-pcsw3vmx 214 8 neutralizing neutralize VBG cord-273505-pcsw3vmx 214 9 titers titer NNS cord-273505-pcsw3vmx 214 10 of of IN cord-273505-pcsw3vmx 214 11 antibodies antibody NNS cord-273505-pcsw3vmx 214 12 is be VBZ cord-273505-pcsw3vmx 214 13 also also RB cord-273505-pcsw3vmx 214 14 a a DT cord-273505-pcsw3vmx 214 15 contributing contribute VBG cord-273505-pcsw3vmx 214 16 factor factor NN cord-273505-pcsw3vmx 214 17 to to IN cord-273505-pcsw3vmx 214 18 the the DT cord-273505-pcsw3vmx 214 19 unfavorable unfavorable JJ cord-273505-pcsw3vmx 214 20 outcome outcome NN cord-273505-pcsw3vmx 214 21 in in IN cord-273505-pcsw3vmx 214 22 influenza influenza NN cord-273505-pcsw3vmx 214 23 infection infection NN cord-273505-pcsw3vmx 214 24 . . . cord-273505-pcsw3vmx 215 1 Prophylactic prophylactic JJ cord-273505-pcsw3vmx 215 2 treatment treatment NN cord-273505-pcsw3vmx 215 3 with with IN cord-273505-pcsw3vmx 215 4 monoclonal monoclonal JJ cord-273505-pcsw3vmx 215 5 antibodies antibody NNS cord-273505-pcsw3vmx 215 6 at at IN cord-273505-pcsw3vmx 215 7 a a DT cord-273505-pcsw3vmx 215 8 low low JJ cord-273505-pcsw3vmx 215 9 dose dose NN cord-273505-pcsw3vmx 215 10 following follow VBG cord-273505-pcsw3vmx 215 11 the the DT cord-273505-pcsw3vmx 215 12 H3N2 H3N2 NNP cord-273505-pcsw3vmx 215 13 virus virus NN cord-273505-pcsw3vmx 215 14 challenge challenge NN cord-273505-pcsw3vmx 215 15 in in IN cord-273505-pcsw3vmx 215 16 mice mouse NNS cord-273505-pcsw3vmx 215 17 has have VBZ cord-273505-pcsw3vmx 215 18 shown show VBN cord-273505-pcsw3vmx 215 19 enhanced enhance VBN cord-273505-pcsw3vmx 215 20 cellular cellular JJ cord-273505-pcsw3vmx 215 21 infiltration infiltration NN cord-273505-pcsw3vmx 215 22 and and CC cord-273505-pcsw3vmx 215 23 lung lung NN cord-273505-pcsw3vmx 215 24 pathology pathology NN cord-273505-pcsw3vmx 215 25 compared compare VBN cord-273505-pcsw3vmx 215 26 to to IN cord-273505-pcsw3vmx 215 27 the the DT cord-273505-pcsw3vmx 215 28 control control NN cord-273505-pcsw3vmx 215 29 group group NN cord-273505-pcsw3vmx 215 30 ( ( -LRB- cord-273505-pcsw3vmx 215 31 204 204 CD cord-273505-pcsw3vmx 215 32 ) ) -RRB- cord-273505-pcsw3vmx 215 33 . . . cord-273505-pcsw3vmx 216 1 In in IN cord-273505-pcsw3vmx 216 2 contrast contrast NN cord-273505-pcsw3vmx 216 3 , , , cord-273505-pcsw3vmx 216 4 a a DT cord-273505-pcsw3vmx 216 5 high high JJ cord-273505-pcsw3vmx 216 6 dose dose NN cord-273505-pcsw3vmx 216 7 prophylaxis prophylaxis NN cord-273505-pcsw3vmx 216 8 showed show VBD cord-273505-pcsw3vmx 216 9 protective protective JJ cord-273505-pcsw3vmx 216 10 effects effect NNS cord-273505-pcsw3vmx 216 11 ( ( -LRB- cord-273505-pcsw3vmx 216 12 204 204 CD cord-273505-pcsw3vmx 216 13 ) ) -RRB- cord-273505-pcsw3vmx 216 14 . . . cord-273505-pcsw3vmx 217 1 Vaccinating vaccinate VBG cord-273505-pcsw3vmx 217 2 pigs pig NNS cord-273505-pcsw3vmx 217 3 against against IN cord-273505-pcsw3vmx 217 4 H1N2 H1N2 NNP cord-273505-pcsw3vmx 217 5 resulted result VBD cord-273505-pcsw3vmx 217 6 in in IN cord-273505-pcsw3vmx 217 7 the the DT cord-273505-pcsw3vmx 217 8 generation generation NN cord-273505-pcsw3vmx 217 9 of of IN cord-273505-pcsw3vmx 217 10 cross cross JJ cord-273505-pcsw3vmx 217 11 - - JJ cord-273505-pcsw3vmx 217 12 reactive reactive JJ cord-273505-pcsw3vmx 217 13 anti anti JJ cord-273505-pcsw3vmx 217 14 - - NNP cord-273505-pcsw3vmx 217 15 pH1N1 pH1N1 NNP cord-273505-pcsw3vmx 217 16 HA2 HA2 NNP cord-273505-pcsw3vmx 217 17 antibodies antibody NNS cord-273505-pcsw3vmx 217 18 , , , cord-273505-pcsw3vmx 217 19 which which WDT cord-273505-pcsw3vmx 217 20 exhibited exhibit VBD cord-273505-pcsw3vmx 217 21 poor poor JJ cord-273505-pcsw3vmx 217 22 neutralizing neutralize VBG cord-273505-pcsw3vmx 217 23 ability ability NN cord-273505-pcsw3vmx 217 24 to to IN cord-273505-pcsw3vmx 217 25 the the DT cord-273505-pcsw3vmx 217 26 HA1 HA1 NNP cord-273505-pcsw3vmx 217 27 domain domain NN cord-273505-pcsw3vmx 217 28 and and CC cord-273505-pcsw3vmx 217 29 enhanced enhance VBD cord-273505-pcsw3vmx 217 30 pH1N1 pH1N1 NNP cord-273505-pcsw3vmx 217 31 infection infection NN cord-273505-pcsw3vmx 217 32 and and CC cord-273505-pcsw3vmx 217 33 lung lung NN cord-273505-pcsw3vmx 217 34 pathology pathology NN cord-273505-pcsw3vmx 217 35 ( ( -LRB- cord-273505-pcsw3vmx 217 36 205 205 CD cord-273505-pcsw3vmx 217 37 ) ) -RRB- cord-273505-pcsw3vmx 217 38 . . . cord-273505-pcsw3vmx 218 1 Besides besides IN cord-273505-pcsw3vmx 218 2 influenza influenza NN cord-273505-pcsw3vmx 218 3 and and CC cord-273505-pcsw3vmx 218 4 potentially potentially RB cord-273505-pcsw3vmx 218 5 MERS MERS NNPS cord-273505-pcsw3vmx 218 6 , , , cord-273505-pcsw3vmx 218 7 the the DT cord-273505-pcsw3vmx 218 8 ADE ADE NNP cord-273505-pcsw3vmx 218 9 phenomenon phenomenon NN cord-273505-pcsw3vmx 218 10 has have VBZ cord-273505-pcsw3vmx 218 11 also also RB cord-273505-pcsw3vmx 218 12 been be VBN cord-273505-pcsw3vmx 218 13 observed observe VBN cord-273505-pcsw3vmx 218 14 in in IN cord-273505-pcsw3vmx 218 15 RSV RSV NNP cord-273505-pcsw3vmx 218 16 infection infection NN cord-273505-pcsw3vmx 218 17 ( ( -LRB- cord-273505-pcsw3vmx 218 18 206 206 CD cord-273505-pcsw3vmx 218 19 ) ) -RRB- cord-273505-pcsw3vmx 218 20 . . . cord-273505-pcsw3vmx 219 1 It -PRON- PRP cord-273505-pcsw3vmx 219 2 has have VBZ cord-273505-pcsw3vmx 219 3 been be VBN cord-273505-pcsw3vmx 219 4 shown show VBN cord-273505-pcsw3vmx 219 5 that that IN cord-273505-pcsw3vmx 219 6 RSV RSV NNP cord-273505-pcsw3vmx 219 7 infections infection NNS cord-273505-pcsw3vmx 219 8 are be VBP cord-273505-pcsw3vmx 219 9 significantly significantly RB cord-273505-pcsw3vmx 219 10 enhanced enhance VBN cord-273505-pcsw3vmx 219 11 in in IN cord-273505-pcsw3vmx 219 12 NK NK NNP cord-273505-pcsw3vmx 219 13 cells cell NNS cord-273505-pcsw3vmx 219 14 previously previously RB cord-273505-pcsw3vmx 219 15 incubated incubate VBN cord-273505-pcsw3vmx 219 16 with with IN cord-273505-pcsw3vmx 219 17 sub sub NN cord-273505-pcsw3vmx 219 18 - - JJ cord-273505-pcsw3vmx 219 19 neutralizing neutralize VBG cord-273505-pcsw3vmx 219 20 titers titer NNS cord-273505-pcsw3vmx 219 21 of of IN cord-273505-pcsw3vmx 219 22 RSV RSV NNP cord-273505-pcsw3vmx 219 23 - - HYPH cord-273505-pcsw3vmx 219 24 specific specific JJ cord-273505-pcsw3vmx 219 25 antibodies antibody NNS cord-273505-pcsw3vmx 219 26 in in IN cord-273505-pcsw3vmx 219 27 vitro vitro FW cord-273505-pcsw3vmx 219 28 , , , cord-273505-pcsw3vmx 219 29 promoting promote VBG cord-273505-pcsw3vmx 219 30 IFN IFN NNP cord-273505-pcsw3vmx 219 31 - - HYPH cord-273505-pcsw3vmx 219 32 γ γ NN cord-273505-pcsw3vmx 219 33 production production NN cord-273505-pcsw3vmx 219 34 of of IN cord-273505-pcsw3vmx 219 35 NK NK NNP cord-273505-pcsw3vmx 219 36 cells cell NNS cord-273505-pcsw3vmx 219 37 ( ( -LRB- cord-273505-pcsw3vmx 219 38 207 207 CD cord-273505-pcsw3vmx 219 39 ) ) -RRB- cord-273505-pcsw3vmx 219 40 . . . cord-273505-pcsw3vmx 220 1 It -PRON- PRP cord-273505-pcsw3vmx 220 2 remains remain VBZ cord-273505-pcsw3vmx 220 3 unclear unclear JJ cord-273505-pcsw3vmx 220 4 whether whether IN cord-273505-pcsw3vmx 220 5 such such JJ cord-273505-pcsw3vmx 220 6 in in IN cord-273505-pcsw3vmx 220 7 vitro vitro FW cord-273505-pcsw3vmx 220 8 enhancement enhancement NN cord-273505-pcsw3vmx 220 9 of of IN cord-273505-pcsw3vmx 220 10 RSV RSV NNP cord-273505-pcsw3vmx 220 11 infection infection NN cord-273505-pcsw3vmx 220 12 has have VBZ cord-273505-pcsw3vmx 220 13 a a DT cord-273505-pcsw3vmx 220 14 correlation correlation NN cord-273505-pcsw3vmx 220 15 with with IN cord-273505-pcsw3vmx 220 16 in in IN cord-273505-pcsw3vmx 220 17 vivo vivo NN cord-273505-pcsw3vmx 220 18 disease disease NN cord-273505-pcsw3vmx 220 19 . . . cord-273505-pcsw3vmx 221 1 Nevertheless nevertheless RB cord-273505-pcsw3vmx 221 2 , , , cord-273505-pcsw3vmx 221 3 the the DT cord-273505-pcsw3vmx 221 4 Fc Fc NNP cord-273505-pcsw3vmx 221 5 - - HYPH cord-273505-pcsw3vmx 221 6 mediated mediate VBN cord-273505-pcsw3vmx 221 7 antibody antibody NN cord-273505-pcsw3vmx 221 8 effector effector NN cord-273505-pcsw3vmx 221 9 functions function NNS cord-273505-pcsw3vmx 221 10 are be VBP cord-273505-pcsw3vmx 221 11 believed believe VBN cord-273505-pcsw3vmx 221 12 to to TO cord-273505-pcsw3vmx 221 13 participate participate VB cord-273505-pcsw3vmx 221 14 in in IN cord-273505-pcsw3vmx 221 15 the the DT cord-273505-pcsw3vmx 221 16 antibody antibody NN cord-273505-pcsw3vmx 221 17 - - HYPH cord-273505-pcsw3vmx 221 18 dependent dependent JJ cord-273505-pcsw3vmx 221 19 enhancement enhancement NN cord-273505-pcsw3vmx 221 20 of of IN cord-273505-pcsw3vmx 221 21 RSV RSV NNP cord-273505-pcsw3vmx 221 22 disease disease NN cord-273505-pcsw3vmx 221 23 ( ( -LRB- cord-273505-pcsw3vmx 221 24 206 206 CD cord-273505-pcsw3vmx 221 25 , , , cord-273505-pcsw3vmx 221 26 208 208 CD cord-273505-pcsw3vmx 221 27 ) ) -RRB- cord-273505-pcsw3vmx 221 28 . . . cord-273505-pcsw3vmx 222 1 To to IN cord-273505-pcsw3vmx 222 2 date date NN cord-273505-pcsw3vmx 222 3 , , , cord-273505-pcsw3vmx 222 4 the the DT cord-273505-pcsw3vmx 222 5 exact exact JJ cord-273505-pcsw3vmx 222 6 role role NN cord-273505-pcsw3vmx 222 7 of of IN cord-273505-pcsw3vmx 222 8 ADE ADE NNP cord-273505-pcsw3vmx 222 9 in in IN cord-273505-pcsw3vmx 222 10 SARS SARS NNP cord-273505-pcsw3vmx 222 11 - - HYPH cord-273505-pcsw3vmx 222 12 CoV-2 CoV-2 NNP cord-273505-pcsw3vmx 222 13 infection infection NN cord-273505-pcsw3vmx 222 14 remains remain VBZ cord-273505-pcsw3vmx 222 15 unclear unclear JJ cord-273505-pcsw3vmx 222 16 . . . cord-273505-pcsw3vmx 223 1 Regarding regard VBG cord-273505-pcsw3vmx 223 2 concerns concern NNS cord-273505-pcsw3vmx 223 3 that that IN cord-273505-pcsw3vmx 223 4 reappearance reappearance NN cord-273505-pcsw3vmx 223 5 of of IN cord-273505-pcsw3vmx 223 6 cross cross JJ cord-273505-pcsw3vmx 223 7 - - JJ cord-273505-pcsw3vmx 223 8 reactive reactive JJ cord-273505-pcsw3vmx 223 9 antibodies antibody NNS cord-273505-pcsw3vmx 223 10 from from IN cord-273505-pcsw3vmx 223 11 other other JJ cord-273505-pcsw3vmx 223 12 serotypes serotype NNS cord-273505-pcsw3vmx 223 13 of of IN cord-273505-pcsw3vmx 223 14 coronavirus coronavirus NN cord-273505-pcsw3vmx 223 15 may may MD cord-273505-pcsw3vmx 223 16 enhance enhance VB cord-273505-pcsw3vmx 223 17 the the DT cord-273505-pcsw3vmx 223 18 current current JJ cord-273505-pcsw3vmx 223 19 infection infection NN cord-273505-pcsw3vmx 223 20 , , , cord-273505-pcsw3vmx 223 21 the the DT cord-273505-pcsw3vmx 223 22 risk risk NN cord-273505-pcsw3vmx 223 23 of of IN cord-273505-pcsw3vmx 223 24 ADE ADE NNP cord-273505-pcsw3vmx 223 25 needs need VBZ cord-273505-pcsw3vmx 223 26 to to TO cord-273505-pcsw3vmx 223 27 be be VB cord-273505-pcsw3vmx 223 28 clarified clarify VBN cord-273505-pcsw3vmx 223 29 when when WRB cord-273505-pcsw3vmx 223 30 treating treat VBG cord-273505-pcsw3vmx 223 31 COVID-19 COVID-19 JJR cord-273505-pcsw3vmx 223 32 patients patient NNS cord-273505-pcsw3vmx 223 33 ( ( -LRB- cord-273505-pcsw3vmx 223 34 203 203 CD cord-273505-pcsw3vmx 223 35 , , , cord-273505-pcsw3vmx 223 36 209 209 CD cord-273505-pcsw3vmx 223 37 ) ) -RRB- cord-273505-pcsw3vmx 223 38 . . . cord-273505-pcsw3vmx 224 1 As as IN cord-273505-pcsw3vmx 224 2 described describe VBN cord-273505-pcsw3vmx 224 3 above above RB cord-273505-pcsw3vmx 224 4 , , , cord-273505-pcsw3vmx 224 5 the the DT cord-273505-pcsw3vmx 224 6 occurrence occurrence NN cord-273505-pcsw3vmx 224 7 of of IN cord-273505-pcsw3vmx 224 8 ADE ADE NNP cord-273505-pcsw3vmx 224 9 requires require VBZ cord-273505-pcsw3vmx 224 10 binding binding NN cord-273505-pcsw3vmx 224 11 of of IN cord-273505-pcsw3vmx 224 12 the the DT cord-273505-pcsw3vmx 224 13 virion virion NN cord-273505-pcsw3vmx 224 14 to to IN cord-273505-pcsw3vmx 224 15 antibodies antibody NNS cord-273505-pcsw3vmx 224 16 at at IN cord-273505-pcsw3vmx 224 17 a a DT cord-273505-pcsw3vmx 224 18 sub sub NN cord-273505-pcsw3vmx 224 19 - - JJ cord-273505-pcsw3vmx 224 20 neutralizing neutralize VBG cord-273505-pcsw3vmx 224 21 concentration concentration NN cord-273505-pcsw3vmx 224 22 and and CC cord-273505-pcsw3vmx 224 23 subsequent subsequent JJ cord-273505-pcsw3vmx 224 24 uptake uptake NN cord-273505-pcsw3vmx 224 25 by by IN cord-273505-pcsw3vmx 224 26 FcγR fcγr NN cord-273505-pcsw3vmx 224 27 - - HYPH cord-273505-pcsw3vmx 224 28 bearing bear VBG cord-273505-pcsw3vmx 224 29 cells cell NNS cord-273505-pcsw3vmx 224 30 ( ( -LRB- cord-273505-pcsw3vmx 224 31 210 210 CD cord-273505-pcsw3vmx 224 32 ) ) -RRB- cord-273505-pcsw3vmx 224 33 . . . cord-273505-pcsw3vmx 225 1 To to TO cord-273505-pcsw3vmx 225 2 inhibit inhibit VB cord-273505-pcsw3vmx 225 3 potential potential JJ cord-273505-pcsw3vmx 225 4 phenomenon phenomenon NN cord-273505-pcsw3vmx 225 5 of of IN cord-273505-pcsw3vmx 225 6 ADE ADE NNP cord-273505-pcsw3vmx 225 7 in in IN cord-273505-pcsw3vmx 225 8 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 225 9 , , , cord-273505-pcsw3vmx 225 10 high high JJ cord-273505-pcsw3vmx 225 11 - - HYPH cord-273505-pcsw3vmx 225 12 dose dose NN cord-273505-pcsw3vmx 225 13 IVIg ivig NN cord-273505-pcsw3vmx 225 14 therapy therapy NN cord-273505-pcsw3vmx 225 15 is be VBZ cord-273505-pcsw3vmx 225 16 therefore therefore RB cord-273505-pcsw3vmx 225 17 proposed propose VBN cord-273505-pcsw3vmx 225 18 ( ( -LRB- cord-273505-pcsw3vmx 225 19 211 211 CD cord-273505-pcsw3vmx 225 20 ) ) -RRB- cord-273505-pcsw3vmx 225 21 . . . cord-273505-pcsw3vmx 226 1 First first RB cord-273505-pcsw3vmx 226 2 , , , cord-273505-pcsw3vmx 226 3 it -PRON- PRP cord-273505-pcsw3vmx 226 4 is be VBZ cord-273505-pcsw3vmx 226 5 unlikely unlikely JJ cord-273505-pcsw3vmx 226 6 to to TO cord-273505-pcsw3vmx 226 7 have have VB cord-273505-pcsw3vmx 226 8 preexisting preexisting JJ cord-273505-pcsw3vmx 226 9 anti anti JJ cord-273505-pcsw3vmx 226 10 - - JJ cord-273505-pcsw3vmx 226 11 SARS SARS NNP cord-273505-pcsw3vmx 226 12 - - HYPH cord-273505-pcsw3vmx 226 13 CoV-2 CoV-2 NNP cord-273505-pcsw3vmx 226 14 antibodies antibody NNS cord-273505-pcsw3vmx 226 15 in in IN cord-273505-pcsw3vmx 226 16 IVIg ivig JJ cord-273505-pcsw3vmx 226 17 preparations preparation NNS cord-273505-pcsw3vmx 226 18 early early RB cord-273505-pcsw3vmx 226 19 in in IN cord-273505-pcsw3vmx 226 20 the the DT cord-273505-pcsw3vmx 226 21 novel novel JJ cord-273505-pcsw3vmx 226 22 epidemic epidemic NN cord-273505-pcsw3vmx 226 23 . . . cord-273505-pcsw3vmx 227 1 Additionally additionally RB cord-273505-pcsw3vmx 227 2 , , , cord-273505-pcsw3vmx 227 3 a a DT cord-273505-pcsw3vmx 227 4 high high JJ cord-273505-pcsw3vmx 227 5 concentration concentration NN cord-273505-pcsw3vmx 227 6 of of IN cord-273505-pcsw3vmx 227 7 non non JJ cord-273505-pcsw3vmx 227 8 - - JJ cord-273505-pcsw3vmx 227 9 neutralizing neutralize VBG cord-273505-pcsw3vmx 227 10 antibodies antibody NNS cord-273505-pcsw3vmx 227 11 , , , cord-273505-pcsw3vmx 227 12 rather rather RB cord-273505-pcsw3vmx 227 13 than than IN cord-273505-pcsw3vmx 227 14 a a DT cord-273505-pcsw3vmx 227 15 regular regular JJ cord-273505-pcsw3vmx 227 16 or or CC cord-273505-pcsw3vmx 227 17 diluted diluted JJ cord-273505-pcsw3vmx 227 18 dose dose NN cord-273505-pcsw3vmx 227 19 , , , cord-273505-pcsw3vmx 227 20 would would MD cord-273505-pcsw3vmx 227 21 integrally integrally RB cord-273505-pcsw3vmx 227 22 saturate saturate VB cord-273505-pcsw3vmx 227 23 activating activate VBG cord-273505-pcsw3vmx 227 24 FcγRs FcγRs NNP cord-273505-pcsw3vmx 227 25 and and CC cord-273505-pcsw3vmx 227 26 FcRn FcRn NNP cord-273505-pcsw3vmx 227 27 , , , cord-273505-pcsw3vmx 227 28 which which WDT cord-273505-pcsw3vmx 227 29 is be VBZ cord-273505-pcsw3vmx 227 30 beneficial beneficial JJ cord-273505-pcsw3vmx 227 31 to to TO cord-273505-pcsw3vmx 227 32 limit limit VB cord-273505-pcsw3vmx 227 33 access access NN cord-273505-pcsw3vmx 227 34 of of IN cord-273505-pcsw3vmx 227 35 immune immune JJ cord-273505-pcsw3vmx 227 36 complexes complex NNS cord-273505-pcsw3vmx 227 37 and and CC cord-273505-pcsw3vmx 227 38 enhance enhance VB cord-273505-pcsw3vmx 227 39 clearance clearance NN cord-273505-pcsw3vmx 227 40 of of IN cord-273505-pcsw3vmx 227 41 inimical inimical JJ cord-273505-pcsw3vmx 227 42 antibodies antibody NNS cord-273505-pcsw3vmx 227 43 , , , cord-273505-pcsw3vmx 227 44 to to TO cord-273505-pcsw3vmx 227 45 ultimately ultimately RB cord-273505-pcsw3vmx 227 46 provide provide VB cord-273505-pcsw3vmx 227 47 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 227 48 effects effect NNS cord-273505-pcsw3vmx 227 49 in in IN cord-273505-pcsw3vmx 227 50 severe severe JJ cord-273505-pcsw3vmx 227 51 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 227 52 patients patient NNS cord-273505-pcsw3vmx 227 53 ( ( -LRB- cord-273505-pcsw3vmx 227 54 211 211 CD cord-273505-pcsw3vmx 227 55 , , , cord-273505-pcsw3vmx 227 56 212 212 CD cord-273505-pcsw3vmx 227 57 ) ) -RRB- cord-273505-pcsw3vmx 227 58 . . . cord-273505-pcsw3vmx 228 1 Based base VBN cord-273505-pcsw3vmx 228 2 on on IN cord-273505-pcsw3vmx 228 3 its -PRON- PRP$ cord-273505-pcsw3vmx 228 4 efficacy efficacy NN cord-273505-pcsw3vmx 228 5 and and CC cord-273505-pcsw3vmx 228 6 supporting support VBG cord-273505-pcsw3vmx 228 7 mechanisms mechanism NNS cord-273505-pcsw3vmx 228 8 in in IN cord-273505-pcsw3vmx 228 9 modulating modulate VBG cord-273505-pcsw3vmx 228 10 the the DT cord-273505-pcsw3vmx 228 11 inflammatory inflammatory JJ cord-273505-pcsw3vmx 228 12 response response NN cord-273505-pcsw3vmx 228 13 and and CC cord-273505-pcsw3vmx 228 14 improving improve VBG cord-273505-pcsw3vmx 228 15 serum serum NN cord-273505-pcsw3vmx 228 16 IgG igg NN cord-273505-pcsw3vmx 228 17 levels level NNS cord-273505-pcsw3vmx 228 18 , , , cord-273505-pcsw3vmx 228 19 high high JJ cord-273505-pcsw3vmx 228 20 - - HYPH cord-273505-pcsw3vmx 228 21 dose dose NN cord-273505-pcsw3vmx 228 22 IVIg ivig NN cord-273505-pcsw3vmx 228 23 therapy therapy NN cord-273505-pcsw3vmx 228 24 is be VBZ cord-273505-pcsw3vmx 228 25 considered consider VBN cord-273505-pcsw3vmx 228 26 for for IN cord-273505-pcsw3vmx 228 27 treatment treatment NN cord-273505-pcsw3vmx 228 28 of of IN cord-273505-pcsw3vmx 228 29 several several JJ cord-273505-pcsw3vmx 228 30 severe severe JJ cord-273505-pcsw3vmx 228 31 viral viral JJ cord-273505-pcsw3vmx 228 32 infections infection NNS cord-273505-pcsw3vmx 228 33 . . . cord-273505-pcsw3vmx 229 1 Potential potential JJ cord-273505-pcsw3vmx 229 2 protective protective JJ cord-273505-pcsw3vmx 229 3 effects effect NNS cord-273505-pcsw3vmx 229 4 of of IN cord-273505-pcsw3vmx 229 5 IVIg ivig JJ cord-273505-pcsw3vmx 229 6 preparations preparation NNS cord-273505-pcsw3vmx 229 7 were be VBD cord-273505-pcsw3vmx 229 8 previously previously RB cord-273505-pcsw3vmx 229 9 shown show VBN cord-273505-pcsw3vmx 229 10 in in IN cord-273505-pcsw3vmx 229 11 influenza influenza NN cord-273505-pcsw3vmx 229 12 - - HYPH cord-273505-pcsw3vmx 229 13 and and CC cord-273505-pcsw3vmx 229 14 RSVinfected rsvinfected JJ cord-273505-pcsw3vmx 229 15 animal animal NN cord-273505-pcsw3vmx 229 16 models model NNS cord-273505-pcsw3vmx 229 17 ( ( -LRB- cord-273505-pcsw3vmx 229 18 213 213 CD cord-273505-pcsw3vmx 229 19 ) ) -RRB- cord-273505-pcsw3vmx 229 20 ( ( -LRB- cord-273505-pcsw3vmx 229 21 214 214 CD cord-273505-pcsw3vmx 229 22 ) ) -RRB- cord-273505-pcsw3vmx 229 23 ( ( -LRB- cord-273505-pcsw3vmx 229 24 215 215 CD cord-273505-pcsw3vmx 229 25 ) ) -RRB- cord-273505-pcsw3vmx 229 26 ( ( -LRB- cord-273505-pcsw3vmx 229 27 216 216 CD cord-273505-pcsw3vmx 229 28 ) ) -RRB- cord-273505-pcsw3vmx 229 29 ( ( -LRB- cord-273505-pcsw3vmx 229 30 217 217 CD cord-273505-pcsw3vmx 229 31 ) ) -RRB- cord-273505-pcsw3vmx 229 32 ( ( -LRB- cord-273505-pcsw3vmx 229 33 218 218 CD cord-273505-pcsw3vmx 229 34 ) ) -RRB- cord-273505-pcsw3vmx 229 35 . . . cord-273505-pcsw3vmx 230 1 In in IN cord-273505-pcsw3vmx 230 2 this this DT cord-273505-pcsw3vmx 230 3 section section NN cord-273505-pcsw3vmx 230 4 , , , cord-273505-pcsw3vmx 230 5 we -PRON- PRP cord-273505-pcsw3vmx 230 6 review review VBP cord-273505-pcsw3vmx 230 7 the the DT cord-273505-pcsw3vmx 230 8 previous previous JJ cord-273505-pcsw3vmx 230 9 clinical clinical JJ cord-273505-pcsw3vmx 230 10 application application NN cord-273505-pcsw3vmx 230 11 of of IN cord-273505-pcsw3vmx 230 12 high high JJ cord-273505-pcsw3vmx 230 13 - - HYPH cord-273505-pcsw3vmx 230 14 dose dose NN cord-273505-pcsw3vmx 230 15 IVIg ivig NN cord-273505-pcsw3vmx 230 16 therapy therapy NN cord-273505-pcsw3vmx 230 17 in in IN cord-273505-pcsw3vmx 230 18 treating treat VBG cord-273505-pcsw3vmx 230 19 viral viral JJ cord-273505-pcsw3vmx 230 20 pneumonia pneumonia NN cord-273505-pcsw3vmx 230 21 such such JJ cord-273505-pcsw3vmx 230 22 as as IN cord-273505-pcsw3vmx 230 23 SARS SARS NNP cord-273505-pcsw3vmx 230 24 , , , cord-273505-pcsw3vmx 230 25 MERS MERS NNP cord-273505-pcsw3vmx 230 26 , , , cord-273505-pcsw3vmx 230 27 influenza influenza NN cord-273505-pcsw3vmx 230 28 and and CC cord-273505-pcsw3vmx 230 29 RSV RSV NNP cord-273505-pcsw3vmx 230 30 disease disease NN cord-273505-pcsw3vmx 230 31 , , , cord-273505-pcsw3vmx 230 32 as as RB cord-273505-pcsw3vmx 230 33 well well RB cord-273505-pcsw3vmx 230 34 as as IN cord-273505-pcsw3vmx 230 35 its -PRON- PRP$ cord-273505-pcsw3vmx 230 36 current current JJ cord-273505-pcsw3vmx 230 37 application application NN cord-273505-pcsw3vmx 230 38 in in IN cord-273505-pcsw3vmx 230 39 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 230 40 ( ( -LRB- cord-273505-pcsw3vmx 230 41 Table Table NNP cord-273505-pcsw3vmx 230 42 2 2 CD cord-273505-pcsw3vmx 230 43 ) ) -RRB- cord-273505-pcsw3vmx 230 44 . . . cord-273505-pcsw3vmx 231 1 During during IN cord-273505-pcsw3vmx 231 2 the the DT cord-273505-pcsw3vmx 231 3 global global JJ cord-273505-pcsw3vmx 231 4 outbreak outbreak NN cord-273505-pcsw3vmx 231 5 of of IN cord-273505-pcsw3vmx 231 6 SARS SARS NNP cord-273505-pcsw3vmx 231 7 in in IN cord-273505-pcsw3vmx 231 8 2003 2003 CD cord-273505-pcsw3vmx 231 9 caused cause VBN cord-273505-pcsw3vmx 231 10 by by IN cord-273505-pcsw3vmx 231 11 SARS SARS NNP cord-273505-pcsw3vmx 231 12 - - HYPH cord-273505-pcsw3vmx 231 13 CoV CoV NNP cord-273505-pcsw3vmx 231 14 , , , cord-273505-pcsw3vmx 231 15 different different JJ cord-273505-pcsw3vmx 231 16 therapeutic therapeutic JJ cord-273505-pcsw3vmx 231 17 modalities modality NNS cord-273505-pcsw3vmx 231 18 ( ( -LRB- cord-273505-pcsw3vmx 231 19 e.g. e.g. RB cord-273505-pcsw3vmx 231 20 , , , cord-273505-pcsw3vmx 231 21 α α NN cord-273505-pcsw3vmx 231 22 - - HYPH cord-273505-pcsw3vmx 231 23 interferon interferon NN cord-273505-pcsw3vmx 231 24 , , , cord-273505-pcsw3vmx 232 1 ribavirin ribavirin RB cord-273505-pcsw3vmx 232 2 , , , cord-273505-pcsw3vmx 232 3 LPV LPV NNP cord-273505-pcsw3vmx 232 4 / / SYM cord-273505-pcsw3vmx 232 5 r r NN cord-273505-pcsw3vmx 232 6 , , , cord-273505-pcsw3vmx 232 7 corticosteroids corticosteroid NNS cord-273505-pcsw3vmx 232 8 , , , cord-273505-pcsw3vmx 232 9 convalescent convalescent JJ cord-273505-pcsw3vmx 232 10 plasma plasma NN cord-273505-pcsw3vmx 232 11 , , , cord-273505-pcsw3vmx 232 12 and and CC cord-273505-pcsw3vmx 232 13 IVIg ivig ADD cord-273505-pcsw3vmx 232 14 ) ) -RRB- cord-273505-pcsw3vmx 232 15 were be VBD cord-273505-pcsw3vmx 232 16 empirically empirically RB cord-273505-pcsw3vmx 232 17 used use VBN cord-273505-pcsw3vmx 232 18 ( ( -LRB- cord-273505-pcsw3vmx 232 19 233 233 CD cord-273505-pcsw3vmx 232 20 ) ) -RRB- cord-273505-pcsw3vmx 232 21 . . . cord-273505-pcsw3vmx 233 1 Although although IN cord-273505-pcsw3vmx 233 2 strong strong JJ cord-273505-pcsw3vmx 233 3 evidence evidence NN cord-273505-pcsw3vmx 233 4 recommending recommend VBG cord-273505-pcsw3vmx 233 5 the the DT cord-273505-pcsw3vmx 233 6 administration administration NN cord-273505-pcsw3vmx 233 7 of of IN cord-273505-pcsw3vmx 233 8 IVIg IVIg NNP cord-273505-pcsw3vmx 233 9 therapy therapy NN cord-273505-pcsw3vmx 233 10 is be VBZ cord-273505-pcsw3vmx 233 11 lacking lack VBG cord-273505-pcsw3vmx 233 12 and and CC cord-273505-pcsw3vmx 233 13 a a DT cord-273505-pcsw3vmx 233 14 previous previous JJ cord-273505-pcsw3vmx 233 15 systemic systemic JJ cord-273505-pcsw3vmx 233 16 review review NN cord-273505-pcsw3vmx 233 17 concluded conclude VBD cord-273505-pcsw3vmx 233 18 that that IN cord-273505-pcsw3vmx 233 19 the the DT cord-273505-pcsw3vmx 233 20 evidence evidence NN cord-273505-pcsw3vmx 233 21 for for IN cord-273505-pcsw3vmx 233 22 efficacy efficacy NN cord-273505-pcsw3vmx 233 23 of of IN cord-273505-pcsw3vmx 233 24 improving improve VBG cord-273505-pcsw3vmx 233 25 prognosis prognosis NN cord-273505-pcsw3vmx 233 26 with with IN cord-273505-pcsw3vmx 233 27 IVIg IVIg NNP cord-273505-pcsw3vmx 233 28 therapy therapy NN cord-273505-pcsw3vmx 233 29 remained remain VBD cord-273505-pcsw3vmx 233 30 inconclusive inconclusive JJ cord-273505-pcsw3vmx 233 31 , , , cord-273505-pcsw3vmx 233 32 some some DT cord-273505-pcsw3vmx 233 33 studies study NNS cord-273505-pcsw3vmx 233 34 commented comment VBD cord-273505-pcsw3vmx 233 35 that that IN cord-273505-pcsw3vmx 233 36 patients patient NNS cord-273505-pcsw3vmx 233 37 seemed seem VBD cord-273505-pcsw3vmx 233 38 to to TO cord-273505-pcsw3vmx 233 39 improve improve VB cord-273505-pcsw3vmx 233 40 upon upon IN cord-273505-pcsw3vmx 233 41 IVIg ivig JJ cord-273505-pcsw3vmx 233 42 treatment treatment NN cord-273505-pcsw3vmx 233 43 ( ( -LRB- cord-273505-pcsw3vmx 233 44 233 233 CD cord-273505-pcsw3vmx 233 45 , , , cord-273505-pcsw3vmx 233 46 234 234 CD cord-273505-pcsw3vmx 233 47 ) ) -RRB- cord-273505-pcsw3vmx 233 48 . . . cord-273505-pcsw3vmx 234 1 In in IN cord-273505-pcsw3vmx 234 2 a a DT cord-273505-pcsw3vmx 234 3 randomized randomized JJ cord-273505-pcsw3vmx 234 4 controlled control VBN cord-273505-pcsw3vmx 234 5 trial trial NN cord-273505-pcsw3vmx 234 6 , , , cord-273505-pcsw3vmx 234 7 IVIg IVIg NNP cord-273505-pcsw3vmx 234 8 therapy therapy NN cord-273505-pcsw3vmx 234 9 efficiently efficiently RB cord-273505-pcsw3vmx 234 10 improved improve VBD cord-273505-pcsw3vmx 234 11 the the DT cord-273505-pcsw3vmx 234 12 serum serum NN cord-273505-pcsw3vmx 234 13 IgG igg NN cord-273505-pcsw3vmx 234 14 concentration concentration NN cord-273505-pcsw3vmx 234 15 of of IN cord-273505-pcsw3vmx 234 16 severe severe JJ cord-273505-pcsw3vmx 234 17 SARS SARS NNP cord-273505-pcsw3vmx 234 18 patients patient NNS cord-273505-pcsw3vmx 234 19 compared compare VBN cord-273505-pcsw3vmx 234 20 to to IN cord-273505-pcsw3vmx 234 21 the the DT cord-273505-pcsw3vmx 234 22 control control NN cord-273505-pcsw3vmx 234 23 group group NN cord-273505-pcsw3vmx 234 24 ( ( -LRB- cord-273505-pcsw3vmx 234 25 222 222 CD cord-273505-pcsw3vmx 234 26 ) ) -RRB- cord-273505-pcsw3vmx 234 27 . . . cord-273505-pcsw3vmx 235 1 However however RB cord-273505-pcsw3vmx 235 2 , , , cord-273505-pcsw3vmx 235 3 possibly possibly RB cord-273505-pcsw3vmx 235 4 due due IN cord-273505-pcsw3vmx 235 5 to to IN cord-273505-pcsw3vmx 235 6 the the DT cord-273505-pcsw3vmx 235 7 inadequately inadequately RB cord-273505-pcsw3vmx 235 8 controlled control VBN cord-273505-pcsw3vmx 235 9 dosage dosage NN cord-273505-pcsw3vmx 235 10 of of IN cord-273505-pcsw3vmx 235 11 glucocorticoids glucocorticoid NNS cord-273505-pcsw3vmx 235 12 and and CC cord-273505-pcsw3vmx 235 13 IVIg ivig JJ cord-273505-pcsw3vmx 235 14 therapy therapy NN cord-273505-pcsw3vmx 235 15 , , , cord-273505-pcsw3vmx 235 16 which which WDT cord-273505-pcsw3vmx 235 17 were be VBD cord-273505-pcsw3vmx 235 18 given give VBN cord-273505-pcsw3vmx 235 19 at at IN cord-273505-pcsw3vmx 235 20 the the DT cord-273505-pcsw3vmx 235 21 discretion discretion NN cord-273505-pcsw3vmx 235 22 of of IN cord-273505-pcsw3vmx 235 23 clinicians clinician NNS cord-273505-pcsw3vmx 235 24 , , , cord-273505-pcsw3vmx 235 25 there there EX cord-273505-pcsw3vmx 235 26 were be VBD cord-273505-pcsw3vmx 235 27 no no DT cord-273505-pcsw3vmx 235 28 significant significant JJ cord-273505-pcsw3vmx 235 29 differences difference NNS cord-273505-pcsw3vmx 235 30 in in IN cord-273505-pcsw3vmx 235 31 the the DT cord-273505-pcsw3vmx 235 32 fatality fatality NN cord-273505-pcsw3vmx 235 33 rates rate NNS cord-273505-pcsw3vmx 235 34 and and CC cord-273505-pcsw3vmx 235 35 the the DT cord-273505-pcsw3vmx 235 36 rates rate NNS cord-273505-pcsw3vmx 235 37 of of IN cord-273505-pcsw3vmx 235 38 nosocomial nosocomial JJ cord-273505-pcsw3vmx 235 39 infection infection NN cord-273505-pcsw3vmx 235 40 of of IN cord-273505-pcsw3vmx 235 41 severe severe JJ cord-273505-pcsw3vmx 235 42 SARS SARS NNP cord-273505-pcsw3vmx 235 43 patients patient NNS cord-273505-pcsw3vmx 235 44 between between IN cord-273505-pcsw3vmx 235 45 the the DT cord-273505-pcsw3vmx 235 46 IVIg IVIg NNP cord-273505-pcsw3vmx 235 47 group group NN cord-273505-pcsw3vmx 235 48 and and CC cord-273505-pcsw3vmx 235 49 the the DT cord-273505-pcsw3vmx 235 50 control control NN cord-273505-pcsw3vmx 235 51 group group NN cord-273505-pcsw3vmx 235 52 ( ( -LRB- cord-273505-pcsw3vmx 235 53 222 222 CD cord-273505-pcsw3vmx 235 54 ) ) -RRB- cord-273505-pcsw3vmx 235 55 . . . cord-273505-pcsw3vmx 236 1 Apart apart RB cord-273505-pcsw3vmx 236 2 from from IN cord-273505-pcsw3vmx 236 3 hypogammaglobulinemia hypogammaglobulinemia NN cord-273505-pcsw3vmx 236 4 , , , cord-273505-pcsw3vmx 236 5 two two CD cord-273505-pcsw3vmx 236 6 further further JJ cord-273505-pcsw3vmx 236 7 common common JJ cord-273505-pcsw3vmx 236 8 features feature NNS cord-273505-pcsw3vmx 236 9 of of IN cord-273505-pcsw3vmx 236 10 severe severe JJ cord-273505-pcsw3vmx 236 11 SARS SARS NNP cord-273505-pcsw3vmx 236 12 are be VBP cord-273505-pcsw3vmx 236 13 leukopenia leukopenia NN cord-273505-pcsw3vmx 236 14 and and CC cord-273505-pcsw3vmx 236 15 thrombocytopenia thrombocytopenia NN cord-273505-pcsw3vmx 236 16 , , , cord-273505-pcsw3vmx 236 17 and and CC cord-273505-pcsw3vmx 236 18 these these DT cord-273505-pcsw3vmx 236 19 features feature NNS cord-273505-pcsw3vmx 236 20 seemed seem VBD cord-273505-pcsw3vmx 236 21 to to TO cord-273505-pcsw3vmx 236 22 improve improve VB cord-273505-pcsw3vmx 236 23 in in IN cord-273505-pcsw3vmx 236 24 SARS SARS NNP cord-273505-pcsw3vmx 236 25 patients patient NNS cord-273505-pcsw3vmx 236 26 upon upon IN cord-273505-pcsw3vmx 236 27 IVIg IVIg NNP cord-273505-pcsw3vmx 236 28 therapy therapy NN cord-273505-pcsw3vmx 236 29 ( ( -LRB- cord-273505-pcsw3vmx 236 30 223 223 CD cord-273505-pcsw3vmx 236 31 , , , cord-273505-pcsw3vmx 236 32 234 234 CD cord-273505-pcsw3vmx 236 33 ) ) -RRB- cord-273505-pcsw3vmx 236 34 . . . cord-273505-pcsw3vmx 237 1 The the DT cord-273505-pcsw3vmx 237 2 peripheral peripheral JJ cord-273505-pcsw3vmx 237 3 WBC WBC NNP cord-273505-pcsw3vmx 237 4 and and CC cord-273505-pcsw3vmx 237 5 platelet platelet NN cord-273505-pcsw3vmx 237 6 count count NN cord-273505-pcsw3vmx 237 7 of of IN cord-273505-pcsw3vmx 237 8 severe severe JJ cord-273505-pcsw3vmx 237 9 SARS SARS NNP cord-273505-pcsw3vmx 237 10 patients patient NNS cord-273505-pcsw3vmx 237 11 significantly significantly RB cord-273505-pcsw3vmx 237 12 increased increase VBD cord-273505-pcsw3vmx 237 13 after after IN cord-273505-pcsw3vmx 237 14 receiving receive VBG cord-273505-pcsw3vmx 237 15 IVIg ivig JJ cord-273505-pcsw3vmx 237 16 therapy therapy NN cord-273505-pcsw3vmx 237 17 without without IN cord-273505-pcsw3vmx 237 18 steroids steroid NNS cord-273505-pcsw3vmx 237 19 , , , cord-273505-pcsw3vmx 237 20 suggesting suggest VBG cord-273505-pcsw3vmx 237 21 a a DT cord-273505-pcsw3vmx 237 22 potential potential JJ cord-273505-pcsw3vmx 237 23 role role NN cord-273505-pcsw3vmx 237 24 of of IN cord-273505-pcsw3vmx 237 25 IVIg IVIg NNP cord-273505-pcsw3vmx 237 26 in in IN cord-273505-pcsw3vmx 237 27 controlling control VBG cord-273505-pcsw3vmx 237 28 leukopenia leukopenia NN cord-273505-pcsw3vmx 237 29 and and CC cord-273505-pcsw3vmx 237 30 thrombocytopenia thrombocytopenia NN cord-273505-pcsw3vmx 237 31 in in IN cord-273505-pcsw3vmx 237 32 SARS SARS NNP cord-273505-pcsw3vmx 237 33 patients patient NNS cord-273505-pcsw3vmx 237 34 ( ( -LRB- cord-273505-pcsw3vmx 237 35 224 224 CD cord-273505-pcsw3vmx 237 36 ) ) -RRB- cord-273505-pcsw3vmx 237 37 . . . cord-273505-pcsw3vmx 238 1 Furthermore furthermore RB cord-273505-pcsw3vmx 238 2 , , , cord-273505-pcsw3vmx 238 3 significant significant JJ cord-273505-pcsw3vmx 238 4 clinical clinical JJ cord-273505-pcsw3vmx 238 5 improvement improvement NN cord-273505-pcsw3vmx 238 6 in in IN cord-273505-pcsw3vmx 238 7 pediatric pediatric JJ cord-273505-pcsw3vmx 238 8 SARS SARS NNP cord-273505-pcsw3vmx 238 9 patients patient NNS cord-273505-pcsw3vmx 238 10 was be VBD cord-273505-pcsw3vmx 238 11 noted note VBN cord-273505-pcsw3vmx 238 12 after after IN cord-273505-pcsw3vmx 238 13 IVIg IVIg NNP cord-273505-pcsw3vmx 238 14 therapy therapy NN cord-273505-pcsw3vmx 238 15 ( ( -LRB- cord-273505-pcsw3vmx 238 16 224 224 CD cord-273505-pcsw3vmx 238 17 ) ) -RRB- cord-273505-pcsw3vmx 238 18 . . . cord-273505-pcsw3vmx 239 1 A a DT cord-273505-pcsw3vmx 239 2 declining decline VBG cord-273505-pcsw3vmx 239 3 WBC WBC NNP cord-273505-pcsw3vmx 239 4 significantly significantly RB cord-273505-pcsw3vmx 239 5 recovered recover VBD cord-273505-pcsw3vmx 239 6 after after IN cord-273505-pcsw3vmx 239 7 IVIg ivig NN cord-273505-pcsw3vmx 239 8 therapy therapy NN cord-273505-pcsw3vmx 239 9 , , , cord-273505-pcsw3vmx 239 10 and and CC cord-273505-pcsw3vmx 239 11 the the DT cord-273505-pcsw3vmx 239 12 temperature temperature NN cord-273505-pcsw3vmx 239 13 of of IN cord-273505-pcsw3vmx 239 14 most most JJS cord-273505-pcsw3vmx 239 15 patients patient NNS cord-273505-pcsw3vmx 239 16 normalized normalize VBN cord-273505-pcsw3vmx 239 17 within within IN cord-273505-pcsw3vmx 239 18 3 3 CD cord-273505-pcsw3vmx 239 19 days day NNS cord-273505-pcsw3vmx 239 20 . . . cord-273505-pcsw3vmx 240 1 Compared compare VBN cord-273505-pcsw3vmx 240 2 to to IN cord-273505-pcsw3vmx 240 3 the the DT cord-273505-pcsw3vmx 240 4 historical historical JJ cord-273505-pcsw3vmx 240 5 controlled control VBN cord-273505-pcsw3vmx 240 6 group group NN cord-273505-pcsw3vmx 240 7 , , , cord-273505-pcsw3vmx 240 8 a a DT cord-273505-pcsw3vmx 240 9 significantly significantly RB cord-273505-pcsw3vmx 240 10 shorter short JJR cord-273505-pcsw3vmx 240 11 time time NN cord-273505-pcsw3vmx 240 12 of of IN cord-273505-pcsw3vmx 240 13 chest chest NN cord-273505-pcsw3vmx 240 14 radiographic radiographic JJ cord-273505-pcsw3vmx 240 15 absorption absorption NN cord-273505-pcsw3vmx 240 16 in in IN cord-273505-pcsw3vmx 240 17 these these DT cord-273505-pcsw3vmx 240 18 patients patient NNS cord-273505-pcsw3vmx 240 19 was be VBD cord-273505-pcsw3vmx 240 20 observed observe VBN cord-273505-pcsw3vmx 240 21 and and CC cord-273505-pcsw3vmx 240 22 indicated indicate VBD cord-273505-pcsw3vmx 240 23 the the DT cord-273505-pcsw3vmx 240 24 potential potential JJ cord-273505-pcsw3vmx 240 25 efficacy efficacy NN cord-273505-pcsw3vmx 240 26 of of IN cord-273505-pcsw3vmx 240 27 IVIg IVIg NNP cord-273505-pcsw3vmx 240 28 in in IN cord-273505-pcsw3vmx 240 29 clinical clinical JJ cord-273505-pcsw3vmx 240 30 improvement improvement NN cord-273505-pcsw3vmx 240 31 and and CC cord-273505-pcsw3vmx 240 32 absorption absorption NN cord-273505-pcsw3vmx 240 33 of of IN cord-273505-pcsw3vmx 240 34 lung lung NN cord-273505-pcsw3vmx 240 35 lesions lesion NNS cord-273505-pcsw3vmx 240 36 . . . cord-273505-pcsw3vmx 241 1 Interestingly interestingly RB cord-273505-pcsw3vmx 241 2 , , , cord-273505-pcsw3vmx 241 3 an an DT cord-273505-pcsw3vmx 241 4 IgM igm NN cord-273505-pcsw3vmx 241 5 - - HYPH cord-273505-pcsw3vmx 241 6 enriched enrich VBN cord-273505-pcsw3vmx 241 7 IVIg ivig NN cord-273505-pcsw3vmx 241 8 preparation preparation NN cord-273505-pcsw3vmx 241 9 also also RB cord-273505-pcsw3vmx 241 10 showed show VBD cord-273505-pcsw3vmx 241 11 significant significant JJ cord-273505-pcsw3vmx 241 12 beneficial beneficial JJ cord-273505-pcsw3vmx 241 13 effects effect NNS cord-273505-pcsw3vmx 241 14 in in IN cord-273505-pcsw3vmx 241 15 deteriorating deteriorate VBG cord-273505-pcsw3vmx 241 16 SARS SARS NNP cord-273505-pcsw3vmx 241 17 patients patient NNS cord-273505-pcsw3vmx 241 18 who who WP cord-273505-pcsw3vmx 241 19 failed fail VBD cord-273505-pcsw3vmx 241 20 corticosteroid corticosteroid NN cord-273505-pcsw3vmx 241 21 and and CC cord-273505-pcsw3vmx 241 22 ribavirin ribavirin NN cord-273505-pcsw3vmx 241 23 treatment treatment NN cord-273505-pcsw3vmx 241 24 ( ( -LRB- cord-273505-pcsw3vmx 241 25 225 225 CD cord-273505-pcsw3vmx 241 26 ) ) -RRB- cord-273505-pcsw3vmx 241 27 . . . cord-273505-pcsw3vmx 242 1 A a DT cord-273505-pcsw3vmx 242 2 significant significant JJ cord-273505-pcsw3vmx 242 3 improvement improvement NN cord-273505-pcsw3vmx 242 4 regarding regard VBG cord-273505-pcsw3vmx 242 5 the the DT cord-273505-pcsw3vmx 242 6 oxygen oxygen NN cord-273505-pcsw3vmx 242 7 requirements requirement NNS cord-273505-pcsw3vmx 242 8 and and CC cord-273505-pcsw3vmx 242 9 radiographic radiographic JJ cord-273505-pcsw3vmx 242 10 scores score NNS cord-273505-pcsw3vmx 242 11 were be VBD cord-273505-pcsw3vmx 242 12 observed observe VBN cord-273505-pcsw3vmx 242 13 after after IN cord-273505-pcsw3vmx 242 14 pentaglobin pentaglobin NNP cord-273505-pcsw3vmx 242 15 therapy therapy NN cord-273505-pcsw3vmx 242 16 , , , cord-273505-pcsw3vmx 242 17 and and CC cord-273505-pcsw3vmx 242 18 most most JJS cord-273505-pcsw3vmx 242 19 patients patient NNS cord-273505-pcsw3vmx 242 20 recovered recover VBD cord-273505-pcsw3vmx 242 21 . . . cord-273505-pcsw3vmx 243 1 It -PRON- PRP cord-273505-pcsw3vmx 243 2 has have VBZ cord-273505-pcsw3vmx 243 3 been be VBN cord-273505-pcsw3vmx 243 4 proposed propose VBN cord-273505-pcsw3vmx 243 5 that that IN cord-273505-pcsw3vmx 243 6 abnormal abnormal JJ cord-273505-pcsw3vmx 243 7 cytokine cytokine NN cord-273505-pcsw3vmx 243 8 levels level NNS cord-273505-pcsw3vmx 243 9 ( ( -LRB- cord-273505-pcsw3vmx 243 10 e.g. e.g. RB cord-273505-pcsw3vmx 243 11 , , , cord-273505-pcsw3vmx 243 12 IL-6 IL-6 NNP cord-273505-pcsw3vmx 243 13 and and CC cord-273505-pcsw3vmx 243 14 TNF TNF NNP cord-273505-pcsw3vmx 243 15 - - HYPH cord-273505-pcsw3vmx 243 16 α α NNP cord-273505-pcsw3vmx 243 17 ) ) -RRB- cord-273505-pcsw3vmx 243 18 are be VBP cord-273505-pcsw3vmx 243 19 correlated correlate VBN cord-273505-pcsw3vmx 243 20 with with IN cord-273505-pcsw3vmx 243 21 poor poor JJ cord-273505-pcsw3vmx 243 22 prognosis prognosis NN cord-273505-pcsw3vmx 243 23 in in IN cord-273505-pcsw3vmx 243 24 SARS SARS NNP cord-273505-pcsw3vmx 243 25 patients patient NNS cord-273505-pcsw3vmx 243 26 , , , cord-273505-pcsw3vmx 243 27 and and CC cord-273505-pcsw3vmx 243 28 that that IN cord-273505-pcsw3vmx 243 29 the the DT cord-273505-pcsw3vmx 243 30 inhibitory inhibitory JJ cord-273505-pcsw3vmx 243 31 effects effect NNS cord-273505-pcsw3vmx 243 32 of of IN cord-273505-pcsw3vmx 243 33 pentaglobin pentaglobin NN cord-273505-pcsw3vmx 243 34 on on IN cord-273505-pcsw3vmx 243 35 cytokine cytokine NN cord-273505-pcsw3vmx 243 36 release release NN cord-273505-pcsw3vmx 243 37 might may MD cord-273505-pcsw3vmx 243 38 represent represent VB cord-273505-pcsw3vmx 243 39 an an DT cord-273505-pcsw3vmx 243 40 essential essential JJ cord-273505-pcsw3vmx 243 41 mechanism mechanism NN cord-273505-pcsw3vmx 243 42 of of IN cord-273505-pcsw3vmx 243 43 action action NN cord-273505-pcsw3vmx 243 44 in in IN cord-273505-pcsw3vmx 243 45 the the DT cord-273505-pcsw3vmx 243 46 treatment treatment NN cord-273505-pcsw3vmx 243 47 of of IN cord-273505-pcsw3vmx 243 48 SARS SARS NNP cord-273505-pcsw3vmx 243 49 ( ( -LRB- cord-273505-pcsw3vmx 243 50 225 225 CD cord-273505-pcsw3vmx 243 51 , , , cord-273505-pcsw3vmx 243 52 235 235 CD cord-273505-pcsw3vmx 243 53 ) ) -RRB- cord-273505-pcsw3vmx 243 54 . . . cord-273505-pcsw3vmx 244 1 MERS MERS NNP cord-273505-pcsw3vmx 244 2 is be VBZ cord-273505-pcsw3vmx 244 3 a a DT cord-273505-pcsw3vmx 244 4 highly highly RB cord-273505-pcsw3vmx 244 5 fatal fatal JJ cord-273505-pcsw3vmx 244 6 respiratory respiratory JJ cord-273505-pcsw3vmx 244 7 disease disease NN cord-273505-pcsw3vmx 244 8 caused cause VBN cord-273505-pcsw3vmx 244 9 by by IN cord-273505-pcsw3vmx 244 10 MERS MERS NNP cord-273505-pcsw3vmx 244 11 - - HYPH cord-273505-pcsw3vmx 244 12 CoV CoV NNP cord-273505-pcsw3vmx 244 13 , , , cord-273505-pcsw3vmx 244 14 with with IN cord-273505-pcsw3vmx 244 15 two two CD cord-273505-pcsw3vmx 244 16 major major JJ cord-273505-pcsw3vmx 244 17 historic historic JJ cord-273505-pcsw3vmx 244 18 outbreaks outbreak NNS cord-273505-pcsw3vmx 244 19 in in IN cord-273505-pcsw3vmx 244 20 2012 2012 CD cord-273505-pcsw3vmx 244 21 and and CC cord-273505-pcsw3vmx 244 22 2015 2015 CD cord-273505-pcsw3vmx 244 23 . . . cord-273505-pcsw3vmx 245 1 The the DT cord-273505-pcsw3vmx 245 2 rapid rapid JJ cord-273505-pcsw3vmx 245 3 deterioration deterioration NN cord-273505-pcsw3vmx 245 4 of of IN cord-273505-pcsw3vmx 245 5 health health NN cord-273505-pcsw3vmx 245 6 in in IN cord-273505-pcsw3vmx 245 7 a a DT cord-273505-pcsw3vmx 245 8 large large JJ cord-273505-pcsw3vmx 245 9 number number NN cord-273505-pcsw3vmx 245 10 of of IN cord-273505-pcsw3vmx 245 11 patients patient NNS cord-273505-pcsw3vmx 245 12 made make VBD cord-273505-pcsw3vmx 245 13 it -PRON- PRP cord-273505-pcsw3vmx 245 14 unrealistic unrealistic JJ cord-273505-pcsw3vmx 245 15 and and CC cord-273505-pcsw3vmx 245 16 unethical unethical JJ cord-273505-pcsw3vmx 245 17 to to TO cord-273505-pcsw3vmx 245 18 perform perform VB cord-273505-pcsw3vmx 245 19 randomized randomize VBN cord-273505-pcsw3vmx 245 20 controlled control VBN cord-273505-pcsw3vmx 245 21 treatment treatment NN cord-273505-pcsw3vmx 245 22 trials trial NNS cord-273505-pcsw3vmx 245 23 . . . cord-273505-pcsw3vmx 246 1 Therefore therefore RB cord-273505-pcsw3vmx 246 2 , , , cord-273505-pcsw3vmx 246 3 the the DT cord-273505-pcsw3vmx 246 4 current current JJ cord-273505-pcsw3vmx 246 5 availability availability NN cord-273505-pcsw3vmx 246 6 of of IN cord-273505-pcsw3vmx 246 7 strong strong JJ cord-273505-pcsw3vmx 246 8 evidence evidence NN cord-273505-pcsw3vmx 246 9 is be VBZ cord-273505-pcsw3vmx 246 10 minimal minimal JJ cord-273505-pcsw3vmx 246 11 , , , cord-273505-pcsw3vmx 246 12 and and CC cord-273505-pcsw3vmx 246 13 only only RB cord-273505-pcsw3vmx 246 14 a a DT cord-273505-pcsw3vmx 246 15 few few JJ cord-273505-pcsw3vmx 246 16 case case NN cord-273505-pcsw3vmx 246 17 series series NN cord-273505-pcsw3vmx 246 18 reported report VBD cord-273505-pcsw3vmx 246 19 administration administration NN cord-273505-pcsw3vmx 246 20 of of IN cord-273505-pcsw3vmx 246 21 IVIg IVIg NNP cord-273505-pcsw3vmx 246 22 late late RB cord-273505-pcsw3vmx 246 23 in in IN cord-273505-pcsw3vmx 246 24 the the DT cord-273505-pcsw3vmx 246 25 course course NN cord-273505-pcsw3vmx 246 26 of of IN cord-273505-pcsw3vmx 246 27 MERS MERS NNPS cord-273505-pcsw3vmx 246 28 . . . cord-273505-pcsw3vmx 247 1 These these DT cord-273505-pcsw3vmx 247 2 studies study NNS cord-273505-pcsw3vmx 247 3 discussed discuss VBD cord-273505-pcsw3vmx 247 4 the the DT cord-273505-pcsw3vmx 247 5 possible possible JJ cord-273505-pcsw3vmx 247 6 efficacy efficacy NN cord-273505-pcsw3vmx 247 7 of of IN cord-273505-pcsw3vmx 247 8 IVIg IVIg NNP cord-273505-pcsw3vmx 247 9 in in IN cord-273505-pcsw3vmx 247 10 reversing reverse VBG cord-273505-pcsw3vmx 247 11 severe severe JJ cord-273505-pcsw3vmx 247 12 thrombocytopenia thrombocytopenia NN cord-273505-pcsw3vmx 247 13 through through IN cord-273505-pcsw3vmx 247 14 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 247 15 mechanisms mechanism NNS cord-273505-pcsw3vmx 247 16 ( ( -LRB- cord-273505-pcsw3vmx 247 17 226 226 CD cord-273505-pcsw3vmx 247 18 , , , cord-273505-pcsw3vmx 247 19 236 236 CD cord-273505-pcsw3vmx 247 20 ) ) -RRB- cord-273505-pcsw3vmx 247 21 . . . cord-273505-pcsw3vmx 248 1 Although although IN cord-273505-pcsw3vmx 248 2 influenza influenza NN cord-273505-pcsw3vmx 248 3 has have VBZ cord-273505-pcsw3vmx 248 4 been be VBN cord-273505-pcsw3vmx 248 5 around around RB cord-273505-pcsw3vmx 248 6 for for IN cord-273505-pcsw3vmx 248 7 centuries century NNS cord-273505-pcsw3vmx 248 8 , , , cord-273505-pcsw3vmx 248 9 severe severe JJ cord-273505-pcsw3vmx 248 10 influenza influenza NN cord-273505-pcsw3vmx 248 11 remains remain VBZ cord-273505-pcsw3vmx 248 12 a a DT cord-273505-pcsw3vmx 248 13 health health NN cord-273505-pcsw3vmx 248 14 challenge challenge NN cord-273505-pcsw3vmx 248 15 for for IN cord-273505-pcsw3vmx 248 16 humans human NNS cord-273505-pcsw3vmx 248 17 . . . cord-273505-pcsw3vmx 249 1 The the DT cord-273505-pcsw3vmx 249 2 complications complication NNS cord-273505-pcsw3vmx 249 3 or or CC cord-273505-pcsw3vmx 249 4 deaths death NNS cord-273505-pcsw3vmx 249 5 are be VBP cord-273505-pcsw3vmx 249 6 usually usually RB cord-273505-pcsw3vmx 249 7 associated associate VBN cord-273505-pcsw3vmx 249 8 with with IN cord-273505-pcsw3vmx 249 9 the the DT cord-273505-pcsw3vmx 249 10 extensive extensive JJ cord-273505-pcsw3vmx 249 11 induction induction NN cord-273505-pcsw3vmx 249 12 of of IN cord-273505-pcsw3vmx 249 13 pro pro JJ cord-273505-pcsw3vmx 249 14 - - JJ cord-273505-pcsw3vmx 249 15 inflammatory inflammatory JJ cord-273505-pcsw3vmx 249 16 cytokines cytokine NNS cord-273505-pcsw3vmx 249 17 in in IN cord-273505-pcsw3vmx 249 18 severely severely RB cord-273505-pcsw3vmx 249 19 affected affect VBN cord-273505-pcsw3vmx 249 20 influenza influenza NN cord-273505-pcsw3vmx 249 21 patients patient NNS cord-273505-pcsw3vmx 249 22 ( ( -LRB- cord-273505-pcsw3vmx 249 23 166 166 CD cord-273505-pcsw3vmx 249 24 ) ) -RRB- cord-273505-pcsw3vmx 249 25 . . . cord-273505-pcsw3vmx 250 1 Immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 250 2 strategies strategy NNS cord-273505-pcsw3vmx 250 3 or or CC cord-273505-pcsw3vmx 250 4 treatments treatment NNS cord-273505-pcsw3vmx 250 5 , , , cord-273505-pcsw3vmx 250 6 including include VBG cord-273505-pcsw3vmx 250 7 amongst amongst IN cord-273505-pcsw3vmx 250 8 others other NNS cord-273505-pcsw3vmx 250 9 corticosteroids corticosteroid NNS cord-273505-pcsw3vmx 250 10 , , , cord-273505-pcsw3vmx 250 11 PPARs ppar NNS cord-273505-pcsw3vmx 250 12 agonists agonist NNS cord-273505-pcsw3vmx 250 13 , , , cord-273505-pcsw3vmx 250 14 S1P1 S1P1 NNP cord-273505-pcsw3vmx 250 15 receptor receptor NN cord-273505-pcsw3vmx 250 16 1 1 CD cord-273505-pcsw3vmx 250 17 agonists agonist NNS cord-273505-pcsw3vmx 250 18 , , , cord-273505-pcsw3vmx 250 19 antioxidants antioxidant NNS cord-273505-pcsw3vmx 250 20 , , , cord-273505-pcsw3vmx 250 21 and and CC cord-273505-pcsw3vmx 250 22 IVIg IVIg NNP cord-273505-pcsw3vmx 250 23 _SP cord-273505-pcsw3vmx 250 24 Frontiers Frontiers NNP cord-273505-pcsw3vmx 250 25 in in IN cord-273505-pcsw3vmx 250 26 Immunology Immunology NNP cord-273505-pcsw3vmx 250 27 | | NNP cord-273505-pcsw3vmx 250 28 www.frontiersin.org www.frontiersin.org IN cord-273505-pcsw3vmx 250 29 ARDS ARDS NNP cord-273505-pcsw3vmx 250 30 , , , cord-273505-pcsw3vmx 250 31 acute acute JJ cord-273505-pcsw3vmx 250 32 respiratory respiratory JJ cord-273505-pcsw3vmx 250 33 distress distress NN cord-273505-pcsw3vmx 250 34 syndrome syndrome NN cord-273505-pcsw3vmx 250 35 ; ; : cord-273505-pcsw3vmx 250 36 N.D. North Dakota NNP cord-273505-pcsw3vmx 250 37 , , , cord-273505-pcsw3vmx 250 38 no no DT cord-273505-pcsw3vmx 250 39 data data NN cord-273505-pcsw3vmx 250 40 ; ; : cord-273505-pcsw3vmx 250 41 SPO SPO NNP cord-273505-pcsw3vmx 250 42 2 2 CD cord-273505-pcsw3vmx 250 43 , , , cord-273505-pcsw3vmx 250 44 surplus surplus JJ cord-273505-pcsw3vmx 250 45 pulse pulse NN cord-273505-pcsw3vmx 250 46 O o NN cord-273505-pcsw3vmx 250 47 2 2 CD cord-273505-pcsw3vmx 250 48 ; ; : cord-273505-pcsw3vmx 250 49 CRP CRP NNP cord-273505-pcsw3vmx 250 50 , , , cord-273505-pcsw3vmx 250 51 C c NN cord-273505-pcsw3vmx 250 52 - - HYPH cord-273505-pcsw3vmx 250 53 reaction reaction NN cord-273505-pcsw3vmx 250 54 protein protein NN cord-273505-pcsw3vmx 250 55 ; ; : cord-273505-pcsw3vmx 250 56 APACHE APACHE NNP cord-273505-pcsw3vmx 250 57 II II NNP cord-273505-pcsw3vmx 250 58 , , , cord-273505-pcsw3vmx 250 59 acute acute JJ cord-273505-pcsw3vmx 250 60 physiology physiology NN cord-273505-pcsw3vmx 250 61 and and CC cord-273505-pcsw3vmx 250 62 chronic chronic JJ cord-273505-pcsw3vmx 250 63 health health NN cord-273505-pcsw3vmx 250 64 evaluation evaluation NN cord-273505-pcsw3vmx 250 65 score score NN cord-273505-pcsw3vmx 250 66 ; ; : cord-273505-pcsw3vmx 250 67 URTI URTI NNP cord-273505-pcsw3vmx 250 68 , , , cord-273505-pcsw3vmx 250 69 upper upper JJ cord-273505-pcsw3vmx 250 70 respiratory respiratory JJ cord-273505-pcsw3vmx 250 71 tract tract NN cord-273505-pcsw3vmx 250 72 infection infection NN cord-273505-pcsw3vmx 250 73 ; ; : cord-273505-pcsw3vmx 250 74 LRTI LRTI NNS cord-273505-pcsw3vmx 250 75 , , , cord-273505-pcsw3vmx 250 76 lower low JJR cord-273505-pcsw3vmx 250 77 respiratory respiratory JJ cord-273505-pcsw3vmx 250 78 tract tract NN cord-273505-pcsw3vmx 250 79 infection infection NN cord-273505-pcsw3vmx 250 80 . . . cord-273505-pcsw3vmx 251 1 * * NFP cord-273505-pcsw3vmx 251 2 All all DT cord-273505-pcsw3vmx 251 3 patients patient NNS cord-273505-pcsw3vmx 251 4 were be VBD cord-273505-pcsw3vmx 251 5 treated treat VBN cord-273505-pcsw3vmx 251 6 with with IN cord-273505-pcsw3vmx 251 7 Arbidol Arbidol NNP cord-273505-pcsw3vmx 251 8 . . . cord-273505-pcsw3vmx 252 1 † † NN cord-273505-pcsw3vmx 252 2 95 95 CD cord-273505-pcsw3vmx 252 3 % % NN cord-273505-pcsw3vmx 252 4 patients patient NNS cord-273505-pcsw3vmx 252 5 were be VBD cord-273505-pcsw3vmx 252 6 treated treat VBN cord-273505-pcsw3vmx 252 7 with with IN cord-273505-pcsw3vmx 252 8 Ribavirin Ribavirin NNP cord-273505-pcsw3vmx 252 9 , , , cord-273505-pcsw3vmx 252 10 26 26 CD cord-273505-pcsw3vmx 252 11 % % NN cord-273505-pcsw3vmx 252 12 with with IN cord-273505-pcsw3vmx 252 13 Oseltamivir Oseltamivir NNP cord-273505-pcsw3vmx 252 14 , , , cord-273505-pcsw3vmx 252 15 and and CC cord-273505-pcsw3vmx 252 16 16 16 CD cord-273505-pcsw3vmx 252 17 % % NN cord-273505-pcsw3vmx 252 18 with with IN cord-273505-pcsw3vmx 252 19 Arbidol Arbidol NNP cord-273505-pcsw3vmx 252 20 . . . cord-273505-pcsw3vmx 253 1 ‡ ‡ NN cord-273505-pcsw3vmx 253 2 80 80 CD cord-273505-pcsw3vmx 253 3 % % NN cord-273505-pcsw3vmx 253 4 patients patient NNS cord-273505-pcsw3vmx 253 5 were be VBD cord-273505-pcsw3vmx 253 6 treated treat VBN cord-273505-pcsw3vmx 253 7 with with IN cord-273505-pcsw3vmx 253 8 Lopinavir Lopinavir NNP cord-273505-pcsw3vmx 253 9 / / SYM cord-273505-pcsw3vmx 253 10 ritonavir ritonavir NNS cord-273505-pcsw3vmx 253 11 , , , cord-273505-pcsw3vmx 253 12 60 60 CD cord-273505-pcsw3vmx 253 13 % % NN cord-273505-pcsw3vmx 253 14 with with IN cord-273505-pcsw3vmx 253 15 interferon interferon NN cord-273505-pcsw3vmx 253 16 , , , cord-273505-pcsw3vmx 253 17 and and CC cord-273505-pcsw3vmx 253 18 30 30 CD cord-273505-pcsw3vmx 253 19 % % NN cord-273505-pcsw3vmx 253 20 with with IN cord-273505-pcsw3vmx 253 21 Arbidol Arbidol NNP cord-273505-pcsw3vmx 253 22 . . . cord-273505-pcsw3vmx 254 1 § § . cord-273505-pcsw3vmx 255 1 Patients patient NNS cord-273505-pcsw3vmx 255 2 1 1 CD cord-273505-pcsw3vmx 255 3 were be VBD cord-273505-pcsw3vmx 255 4 treated treat VBN cord-273505-pcsw3vmx 255 5 with with IN cord-273505-pcsw3vmx 255 6 Oseltamivir Oseltamivir NNP cord-273505-pcsw3vmx 255 7 , , , cord-273505-pcsw3vmx 255 8 and and CC cord-273505-pcsw3vmx 255 9 Patients Patients NNP cord-273505-pcsw3vmx 255 10 3 3 CD cord-273505-pcsw3vmx 255 11 with with IN cord-273505-pcsw3vmx 255 12 steroids steroid NNS cord-273505-pcsw3vmx 255 13 and and CC cord-273505-pcsw3vmx 255 14 Lopinavir Lopinavir NNP cord-273505-pcsw3vmx 255 15 / / SYM cord-273505-pcsw3vmx 255 16 ritonavir ritonavir NNS cord-273505-pcsw3vmx 255 17 . . . cord-273505-pcsw3vmx 256 1 ¶ ¶ NFP cord-273505-pcsw3vmx 257 1 Patients patient NNS cord-273505-pcsw3vmx 257 2 received receive VBD cord-273505-pcsw3vmx 257 3 IVIg IVIg NNS cord-273505-pcsw3vmx 257 4 at at IN cord-273505-pcsw3vmx 257 5 2.5 2.5 CD cord-273505-pcsw3vmx 257 6 - - SYM cord-273505-pcsw3vmx 257 7 10 10 CD cord-273505-pcsw3vmx 257 8 g g NN cord-273505-pcsw3vmx 257 9 / / SYM cord-273505-pcsw3vmx 257 10 d d NN cord-273505-pcsw3vmx 257 11 for for IN cord-273505-pcsw3vmx 257 12 2 2 CD cord-273505-pcsw3vmx 257 13 - - SYM cord-273505-pcsw3vmx 257 14 13 13 CD cord-273505-pcsw3vmx 257 15 d d NN cord-273505-pcsw3vmx 257 16 , , , cord-273505-pcsw3vmx 257 17 average average JJ cord-273505-pcsw3vmx 257 18 to to IN cord-273505-pcsw3vmx 257 19 5 5 CD cord-273505-pcsw3vmx 257 20 g g NN cord-273505-pcsw3vmx 257 21 / / SYM cord-273505-pcsw3vmx 257 22 d d NN cord-273505-pcsw3vmx 257 23 for for IN cord-273505-pcsw3vmx 257 24 5 5 CD cord-273505-pcsw3vmx 257 25 d. d. NNP cord-273505-pcsw3vmx 258 1 These these DT cord-273505-pcsw3vmx 258 2 patients patient NNS cord-273505-pcsw3vmx 258 3 were be VBD cord-273505-pcsw3vmx 258 4 treated treat VBN cord-273505-pcsw3vmx 258 5 with with IN cord-273505-pcsw3vmx 258 6 Ribavirin Ribavirin NNP cord-273505-pcsw3vmx 258 7 . . . cord-273505-pcsw3vmx 259 1 * * NFP cord-273505-pcsw3vmx 260 1 * * NFP cord-273505-pcsw3vmx 260 2 All all DT cord-273505-pcsw3vmx 260 3 patients patient NNS cord-273505-pcsw3vmx 260 4 were be VBD cord-273505-pcsw3vmx 260 5 treated treat VBN cord-273505-pcsw3vmx 260 6 with with IN cord-273505-pcsw3vmx 260 7 Oseltamivir Oseltamivir NNP cord-273505-pcsw3vmx 260 8 , , , cord-273505-pcsw3vmx 260 9 and and CC cord-273505-pcsw3vmx 260 10 8.8 8.8 CD cord-273505-pcsw3vmx 260 11 % % NN cord-273505-pcsw3vmx 260 12 with with IN cord-273505-pcsw3vmx 260 13 zanamivir zanamivir NNP cord-273505-pcsw3vmx 260 14 . . . cord-273505-pcsw3vmx 261 1 † † UH cord-273505-pcsw3vmx 261 2 † † NN cord-273505-pcsw3vmx 262 1 All all DT cord-273505-pcsw3vmx 262 2 patients patient NNS cord-273505-pcsw3vmx 262 3 were be VBD cord-273505-pcsw3vmx 262 4 treated treat VBN cord-273505-pcsw3vmx 262 5 with with IN cord-273505-pcsw3vmx 262 6 Oseltamivir Oseltamivir NNP cord-273505-pcsw3vmx 262 7 . . . cord-273505-pcsw3vmx 263 1 Frontiers frontier NNS cord-273505-pcsw3vmx 263 2 in in IN cord-273505-pcsw3vmx 263 3 Immunology Immunology NNP cord-273505-pcsw3vmx 263 4 | | NNP cord-273505-pcsw3vmx 263 5 www.frontiersin.org www.frontiersin.org NN cord-273505-pcsw3vmx 263 6 therapy therapy NN cord-273505-pcsw3vmx 263 7 , , , cord-273505-pcsw3vmx 263 8 have have VBP cord-273505-pcsw3vmx 263 9 been be VBN cord-273505-pcsw3vmx 263 10 widely widely RB cord-273505-pcsw3vmx 263 11 considered consider VBN cord-273505-pcsw3vmx 263 12 as as IN cord-273505-pcsw3vmx 263 13 adjunctive adjunctive JJ cord-273505-pcsw3vmx 263 14 treatments treatment NNS cord-273505-pcsw3vmx 263 15 for for IN cord-273505-pcsw3vmx 263 16 cytokine cytokine JJ cord-273505-pcsw3vmx 263 17 storms storm NNS cord-273505-pcsw3vmx 263 18 in in IN cord-273505-pcsw3vmx 263 19 influenza influenza NN cord-273505-pcsw3vmx 263 20 ( ( -LRB- cord-273505-pcsw3vmx 263 21 237 237 CD cord-273505-pcsw3vmx 263 22 ) ) -RRB- cord-273505-pcsw3vmx 263 23 . . . cord-273505-pcsw3vmx 264 1 In in IN cord-273505-pcsw3vmx 264 2 a a DT cord-273505-pcsw3vmx 264 3 previous previous JJ cord-273505-pcsw3vmx 264 4 randomized randomized JJ cord-273505-pcsw3vmx 264 5 controlled control VBN cord-273505-pcsw3vmx 264 6 trial trial NN cord-273505-pcsw3vmx 264 7 , , , cord-273505-pcsw3vmx 264 8 patients patient NNS cord-273505-pcsw3vmx 264 9 infected infect VBN cord-273505-pcsw3vmx 264 10 with with IN cord-273505-pcsw3vmx 264 11 the the DT cord-273505-pcsw3vmx 264 12 severe severe JJ cord-273505-pcsw3vmx 264 13 2009 2009 CD cord-273505-pcsw3vmx 264 14 pandemic pandemic NN cord-273505-pcsw3vmx 264 15 influenza influenza NN cord-273505-pcsw3vmx 264 16 A A NNP cord-273505-pcsw3vmx 264 17 ( ( -LRB- cord-273505-pcsw3vmx 264 18 H1N1 H1N1 NNP cord-273505-pcsw3vmx 264 19 ) ) -RRB- cord-273505-pcsw3vmx 264 20 were be VBD cord-273505-pcsw3vmx 264 21 randomized randomize VBN cord-273505-pcsw3vmx 264 22 to to TO cord-273505-pcsw3vmx 264 23 receive receive VB cord-273505-pcsw3vmx 264 24 0.4 0.4 CD cord-273505-pcsw3vmx 264 25 g g NN cord-273505-pcsw3vmx 264 26 / / SYM cord-273505-pcsw3vmx 264 27 kg kg NN cord-273505-pcsw3vmx 264 28 for for IN cord-273505-pcsw3vmx 264 29 one one CD cord-273505-pcsw3vmx 264 30 dose dose NN cord-273505-pcsw3vmx 264 31 of of IN cord-273505-pcsw3vmx 264 32 Flu Flu NNP cord-273505-pcsw3vmx 264 33 - - HYPH cord-273505-pcsw3vmx 264 34 IVIg IVIg NNP cord-273505-pcsw3vmx 264 35 ( ( -LRB- cord-273505-pcsw3vmx 264 36 antiinfluenza antiinfluenza NNP cord-273505-pcsw3vmx 264 37 hyperimmune hyperimmune NNP cord-273505-pcsw3vmx 264 38 intravenous intravenous JJ cord-273505-pcsw3vmx 264 39 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 264 40 with with IN cord-273505-pcsw3vmx 264 41 high high JJ cord-273505-pcsw3vmx 264 42 HAI HAI NNP cord-273505-pcsw3vmx 264 43 antibodies antibody NNS cord-273505-pcsw3vmx 264 44 level level NN cord-273505-pcsw3vmx 264 45 ) ) -RRB- cord-273505-pcsw3vmx 264 46 or or CC cord-273505-pcsw3vmx 264 47 IVIg ivig NN cord-273505-pcsw3vmx 264 48 therapy therapy NN cord-273505-pcsw3vmx 264 49 ( ( -LRB- cord-273505-pcsw3vmx 264 50 227 227 CD cord-273505-pcsw3vmx 264 51 ) ) -RRB- cord-273505-pcsw3vmx 264 52 . . . cord-273505-pcsw3vmx 265 1 Patients patient NNS cord-273505-pcsw3vmx 265 2 who who WP cord-273505-pcsw3vmx 265 3 received receive VBD cord-273505-pcsw3vmx 265 4 Flu Flu NNP cord-273505-pcsw3vmx 265 5 - - HYPH cord-273505-pcsw3vmx 265 6 IVIg IVIg NNP cord-273505-pcsw3vmx 265 7 showed show VBD cord-273505-pcsw3vmx 265 8 a a DT cord-273505-pcsw3vmx 265 9 greater great JJR cord-273505-pcsw3vmx 265 10 rate rate NN cord-273505-pcsw3vmx 265 11 of of IN cord-273505-pcsw3vmx 265 12 viral viral JJ cord-273505-pcsw3vmx 265 13 load load NN cord-273505-pcsw3vmx 265 14 reduction reduction NN cord-273505-pcsw3vmx 265 15 than than IN cord-273505-pcsw3vmx 265 16 the the DT cord-273505-pcsw3vmx 265 17 IVIg IVIg NNP cord-273505-pcsw3vmx 265 18 group group NN cord-273505-pcsw3vmx 265 19 . . . cord-273505-pcsw3vmx 266 1 However however RB cord-273505-pcsw3vmx 266 2 , , , cord-273505-pcsw3vmx 266 3 there there EX cord-273505-pcsw3vmx 266 4 was be VBD cord-273505-pcsw3vmx 266 5 no no DT cord-273505-pcsw3vmx 266 6 significant significant JJ cord-273505-pcsw3vmx 266 7 difference difference NN cord-273505-pcsw3vmx 266 8 in in IN cord-273505-pcsw3vmx 266 9 the the DT cord-273505-pcsw3vmx 266 10 cytokine cytokine NN cord-273505-pcsw3vmx 266 11 profiles profile NNS cord-273505-pcsw3vmx 266 12 ( ( -LRB- cord-273505-pcsw3vmx 266 13 e.g. e.g. RB cord-273505-pcsw3vmx 266 14 , , , cord-273505-pcsw3vmx 266 15 IFN IFN NNP cord-273505-pcsw3vmx 266 16 - - HYPH cord-273505-pcsw3vmx 266 17 α2 α2 NNP cord-273505-pcsw3vmx 266 18 , , , cord-273505-pcsw3vmx 266 19 IL-1α IL-1α NNP cord-273505-pcsw3vmx 266 20 , , , cord-273505-pcsw3vmx 266 21 IL-6 IL-6 NNP cord-273505-pcsw3vmx 266 22 , , , cord-273505-pcsw3vmx 266 23 IL-10 IL-10 NNP cord-273505-pcsw3vmx 266 24 , , , cord-273505-pcsw3vmx 266 25 IL-15 IL-15 NNP cord-273505-pcsw3vmx 266 26 , , , cord-273505-pcsw3vmx 266 27 IL-1ra IL-1ra NNP cord-273505-pcsw3vmx 266 28 , , , cord-273505-pcsw3vmx 266 29 MCP-1 MCP-1 NNP cord-273505-pcsw3vmx 266 30 , , , cord-273505-pcsw3vmx 266 31 MIP-1α MIP-1α NNP cord-273505-pcsw3vmx 266 32 , , , cord-273505-pcsw3vmx 266 33 GM GM NNP cord-273505-pcsw3vmx 266 34 - - HYPH cord-273505-pcsw3vmx 266 35 CSF CSF NNP cord-273505-pcsw3vmx 266 36 , , , cord-273505-pcsw3vmx 266 37 TNF TNF NNP cord-273505-pcsw3vmx 266 38 - - HYPH cord-273505-pcsw3vmx 266 39 α α NNP cord-273505-pcsw3vmx 266 40 ) ) -RRB- cord-273505-pcsw3vmx 266 41 between between IN cord-273505-pcsw3vmx 266 42 the the DT cord-273505-pcsw3vmx 266 43 IVIg IVIg NNP cord-273505-pcsw3vmx 266 44 and and CC cord-273505-pcsw3vmx 266 45 Flu Flu NNP cord-273505-pcsw3vmx 266 46 - - HYPH cord-273505-pcsw3vmx 266 47 IVIg IVIg NNP cord-273505-pcsw3vmx 266 48 group group NN cord-273505-pcsw3vmx 266 49 on on IN cord-273505-pcsw3vmx 266 50 day day NN cord-273505-pcsw3vmx 266 51 5 5 CD cord-273505-pcsw3vmx 266 52 . . . cord-273505-pcsw3vmx 267 1 Subgroup subgroup NN cord-273505-pcsw3vmx 267 2 multivariate multivariate JJ cord-273505-pcsw3vmx 267 3 analysis analysis NN cord-273505-pcsw3vmx 267 4 of of IN cord-273505-pcsw3vmx 267 5 patients patient NNS cord-273505-pcsw3vmx 267 6 receiving receive VBG cord-273505-pcsw3vmx 267 7 treatment treatment NN cord-273505-pcsw3vmx 267 8 within within IN cord-273505-pcsw3vmx 267 9 5 5 CD cord-273505-pcsw3vmx 267 10 days day NNS cord-273505-pcsw3vmx 267 11 of of IN cord-273505-pcsw3vmx 267 12 symptom symptom NN cord-273505-pcsw3vmx 267 13 onset onset NN cord-273505-pcsw3vmx 267 14 revealed reveal VBD cord-273505-pcsw3vmx 267 15 that that IN cord-273505-pcsw3vmx 267 16 Flu Flu NNP cord-273505-pcsw3vmx 267 17 - - HYPH cord-273505-pcsw3vmx 267 18 IVIg IVIg NNP cord-273505-pcsw3vmx 267 19 therapy therapy NN cord-273505-pcsw3vmx 267 20 , , , cord-273505-pcsw3vmx 267 21 rather rather RB cord-273505-pcsw3vmx 267 22 than than IN cord-273505-pcsw3vmx 267 23 IVIg ivig NN cord-273505-pcsw3vmx 267 24 therapy therapy NN cord-273505-pcsw3vmx 267 25 , , , cord-273505-pcsw3vmx 267 26 was be VBD cord-273505-pcsw3vmx 267 27 the the DT cord-273505-pcsw3vmx 267 28 only only JJ cord-273505-pcsw3vmx 267 29 factor factor NN cord-273505-pcsw3vmx 267 30 that that WDT cord-273505-pcsw3vmx 267 31 independently independently RB cord-273505-pcsw3vmx 267 32 reduced reduce VBN cord-273505-pcsw3vmx 267 33 mortality mortality NN cord-273505-pcsw3vmx 267 34 . . . cord-273505-pcsw3vmx 268 1 In in IN cord-273505-pcsw3vmx 268 2 contrast contrast NN cord-273505-pcsw3vmx 268 3 , , , cord-273505-pcsw3vmx 268 4 other other JJ cord-273505-pcsw3vmx 268 5 RCTs rct NNS cord-273505-pcsw3vmx 268 6 using use VBG cord-273505-pcsw3vmx 268 7 IVIg ivig JJ cord-273505-pcsw3vmx 268 8 treatment treatment NN cord-273505-pcsw3vmx 268 9 at at IN cord-273505-pcsw3vmx 268 10 high high JJ cord-273505-pcsw3vmx 268 11 doses dose NNS cord-273505-pcsw3vmx 268 12 have have VBP cord-273505-pcsw3vmx 268 13 shown show VBN cord-273505-pcsw3vmx 268 14 improved improve VBN cord-273505-pcsw3vmx 268 15 survival survival NN cord-273505-pcsw3vmx 268 16 . . . cord-273505-pcsw3vmx 269 1 In in IN cord-273505-pcsw3vmx 269 2 two two CD cord-273505-pcsw3vmx 269 3 similar similar JJ cord-273505-pcsw3vmx 269 4 studies study NNS cord-273505-pcsw3vmx 269 5 , , , cord-273505-pcsw3vmx 269 6 pediatric pediatric JJ cord-273505-pcsw3vmx 269 7 patients patient NNS cord-273505-pcsw3vmx 269 8 with with IN cord-273505-pcsw3vmx 269 9 the the DT cord-273505-pcsw3vmx 269 10 severe severe JJ cord-273505-pcsw3vmx 269 11 2009 2009 CD cord-273505-pcsw3vmx 269 12 pandemic pandemic NN cord-273505-pcsw3vmx 269 13 influenza influenza NN cord-273505-pcsw3vmx 269 14 A A NNP cord-273505-pcsw3vmx 269 15 ( ( -LRB- cord-273505-pcsw3vmx 269 16 H1N1 H1N1 NNP cord-273505-pcsw3vmx 269 17 ) ) -RRB- cord-273505-pcsw3vmx 269 18 were be VBD cord-273505-pcsw3vmx 269 19 randomized randomize VBN cord-273505-pcsw3vmx 269 20 to to TO cord-273505-pcsw3vmx 269 21 receive receive VB cord-273505-pcsw3vmx 269 22 standard standard JJ cord-273505-pcsw3vmx 269 23 care care NN cord-273505-pcsw3vmx 269 24 or or CC cord-273505-pcsw3vmx 269 25 standard standard JJ cord-273505-pcsw3vmx 269 26 care care NN cord-273505-pcsw3vmx 269 27 plus plus CC cord-273505-pcsw3vmx 269 28 1 1 CD cord-273505-pcsw3vmx 269 29 g g NN cord-273505-pcsw3vmx 269 30 / / SYM cord-273505-pcsw3vmx 269 31 kg kg NNP cord-273505-pcsw3vmx 269 32 / / SYM cord-273505-pcsw3vmx 269 33 d d DT cord-273505-pcsw3vmx 269 34 high high JJ cord-273505-pcsw3vmx 269 35 - - HYPH cord-273505-pcsw3vmx 269 36 dose dose NN cord-273505-pcsw3vmx 269 37 IVIg ivig NN cord-273505-pcsw3vmx 269 38 for for IN cord-273505-pcsw3vmx 269 39 2 2 CD cord-273505-pcsw3vmx 269 40 days day NNS cord-273505-pcsw3vmx 269 41 ( ( -LRB- cord-273505-pcsw3vmx 269 42 228 228 CD cord-273505-pcsw3vmx 269 43 , , , cord-273505-pcsw3vmx 269 44 229 229 CD cord-273505-pcsw3vmx 269 45 ) ) -RRB- cord-273505-pcsw3vmx 269 46 . . . cord-273505-pcsw3vmx 270 1 Significant significant JJ cord-273505-pcsw3vmx 270 2 clinical clinical JJ cord-273505-pcsw3vmx 270 3 improvement improvement NN cord-273505-pcsw3vmx 270 4 with with IN cord-273505-pcsw3vmx 270 5 regards regard NNS cord-273505-pcsw3vmx 270 6 to to IN cord-273505-pcsw3vmx 270 7 temperature temperature NN cord-273505-pcsw3vmx 270 8 normalization normalization NN cord-273505-pcsw3vmx 270 9 , , , cord-273505-pcsw3vmx 270 10 reduction reduction NN cord-273505-pcsw3vmx 270 11 of of IN cord-273505-pcsw3vmx 270 12 cough cough NN cord-273505-pcsw3vmx 270 13 , , , cord-273505-pcsw3vmx 270 14 rhinorrhea rhinorrhea NNP cord-273505-pcsw3vmx 270 15 , , , cord-273505-pcsw3vmx 270 16 tachypnea tachypnea NNP cord-273505-pcsw3vmx 270 17 , , , cord-273505-pcsw3vmx 270 18 respiratory respiratory JJ cord-273505-pcsw3vmx 270 19 sounds sound NNS cord-273505-pcsw3vmx 270 20 ( ( -LRB- cord-273505-pcsw3vmx 270 21 namely namely RB cord-273505-pcsw3vmx 270 22 wheeze wheeze NN cord-273505-pcsw3vmx 270 23 or or CC cord-273505-pcsw3vmx 270 24 rhonchi rhonchi NNP cord-273505-pcsw3vmx 270 25 ) ) -RRB- cord-273505-pcsw3vmx 270 26 , , , cord-273505-pcsw3vmx 270 27 and and CC cord-273505-pcsw3vmx 270 28 chest chest NN cord-273505-pcsw3vmx 270 29 radiographic radiographic JJ cord-273505-pcsw3vmx 270 30 lesions lesion NNS cord-273505-pcsw3vmx 270 31 were be VBD cord-273505-pcsw3vmx 270 32 observed observe VBN cord-273505-pcsw3vmx 270 33 in in IN cord-273505-pcsw3vmx 270 34 the the DT cord-273505-pcsw3vmx 270 35 IVIg ivig JJ cord-273505-pcsw3vmx 270 36 group group NN cord-273505-pcsw3vmx 270 37 compared compare VBN cord-273505-pcsw3vmx 270 38 to to IN cord-273505-pcsw3vmx 270 39 the the DT cord-273505-pcsw3vmx 270 40 control control NN cord-273505-pcsw3vmx 270 41 group group NN cord-273505-pcsw3vmx 270 42 , , , cord-273505-pcsw3vmx 270 43 revealing reveal VBG cord-273505-pcsw3vmx 270 44 a a DT cord-273505-pcsw3vmx 270 45 possible possible JJ cord-273505-pcsw3vmx 270 46 clinical clinical JJ cord-273505-pcsw3vmx 270 47 benefit benefit NN cord-273505-pcsw3vmx 270 48 of of IN cord-273505-pcsw3vmx 270 49 high high JJ cord-273505-pcsw3vmx 270 50 - - HYPH cord-273505-pcsw3vmx 270 51 dose dose NN cord-273505-pcsw3vmx 270 52 IVIg ivig NN cord-273505-pcsw3vmx 270 53 therapy therapy NN cord-273505-pcsw3vmx 270 54 for for IN cord-273505-pcsw3vmx 270 55 the the DT cord-273505-pcsw3vmx 270 56 improvement improvement NN cord-273505-pcsw3vmx 270 57 of of IN cord-273505-pcsw3vmx 270 58 clinical clinical JJ cord-273505-pcsw3vmx 270 59 symptoms symptom NNS cord-273505-pcsw3vmx 270 60 in in IN cord-273505-pcsw3vmx 270 61 pediatric pediatric JJ cord-273505-pcsw3vmx 270 62 patients patient NNS cord-273505-pcsw3vmx 270 63 with with IN cord-273505-pcsw3vmx 270 64 severe severe JJ cord-273505-pcsw3vmx 270 65 influenza influenza NN cord-273505-pcsw3vmx 271 1 A a DT cord-273505-pcsw3vmx 271 2 H1N1 H1N1 NNP cord-273505-pcsw3vmx 271 3 ( ( -LRB- cord-273505-pcsw3vmx 271 4 228 228 CD cord-273505-pcsw3vmx 271 5 , , , cord-273505-pcsw3vmx 271 6 229 229 CD cord-273505-pcsw3vmx 271 7 ) ) -RRB- cord-273505-pcsw3vmx 271 8 . . . cord-273505-pcsw3vmx 272 1 RSV RSV NNP cord-273505-pcsw3vmx 272 2 is be VBZ cord-273505-pcsw3vmx 272 3 a a DT cord-273505-pcsw3vmx 272 4 major major JJ cord-273505-pcsw3vmx 272 5 respiratory respiratory JJ cord-273505-pcsw3vmx 272 6 pathogen pathogen NN cord-273505-pcsw3vmx 272 7 that that WDT cord-273505-pcsw3vmx 272 8 causes cause VBZ cord-273505-pcsw3vmx 272 9 extensive extensive JJ cord-273505-pcsw3vmx 272 10 respiratory respiratory JJ cord-273505-pcsw3vmx 272 11 symptoms symptom NNS cord-273505-pcsw3vmx 272 12 , , , cord-273505-pcsw3vmx 272 13 including include VBG cord-273505-pcsw3vmx 272 14 both both CC cord-273505-pcsw3vmx 272 15 upper upper JJ cord-273505-pcsw3vmx 272 16 and and CC cord-273505-pcsw3vmx 272 17 severe severe JJ cord-273505-pcsw3vmx 272 18 lower low JJR cord-273505-pcsw3vmx 272 19 respiratory respiratory JJ cord-273505-pcsw3vmx 272 20 tract tract NN cord-273505-pcsw3vmx 272 21 infection infection NN cord-273505-pcsw3vmx 272 22 ( ( -LRB- cord-273505-pcsw3vmx 272 23 URTI URTI NNP cord-273505-pcsw3vmx 272 24 / / SYM cord-273505-pcsw3vmx 272 25 LRTI LRTI NNP cord-273505-pcsw3vmx 272 26 ) ) -RRB- cord-273505-pcsw3vmx 272 27 in in IN cord-273505-pcsw3vmx 272 28 infants infant NNS cord-273505-pcsw3vmx 272 29 , , , cord-273505-pcsw3vmx 272 30 the the DT cord-273505-pcsw3vmx 272 31 elderly elderly JJ cord-273505-pcsw3vmx 272 32 , , , cord-273505-pcsw3vmx 272 33 and and CC cord-273505-pcsw3vmx 272 34 immunocompromised immunocompromised JJ cord-273505-pcsw3vmx 272 35 individuals individual NNS cord-273505-pcsw3vmx 272 36 ( ( -LRB- cord-273505-pcsw3vmx 272 37 238 238 CD cord-273505-pcsw3vmx 272 38 ) ) -RRB- cord-273505-pcsw3vmx 272 39 . . . cord-273505-pcsw3vmx 273 1 Available available JJ cord-273505-pcsw3vmx 273 2 therapies therapy NNS cord-273505-pcsw3vmx 273 3 are be VBP cord-273505-pcsw3vmx 273 4 limited limit VBN cord-273505-pcsw3vmx 273 5 to to IN cord-273505-pcsw3vmx 273 6 RBV RBV NNP cord-273505-pcsw3vmx 273 7 , , , cord-273505-pcsw3vmx 273 8 IVIg IVIg NNP cord-273505-pcsw3vmx 273 9 , , , cord-273505-pcsw3vmx 273 10 and and CC cord-273505-pcsw3vmx 273 11 palivizumab palivizumab NNS cord-273505-pcsw3vmx 273 12 , , , cord-273505-pcsw3vmx 273 13 but but CC cord-273505-pcsw3vmx 273 14 the the DT cord-273505-pcsw3vmx 273 15 use use NN cord-273505-pcsw3vmx 273 16 of of IN cord-273505-pcsw3vmx 273 17 IVIg ivig NN cord-273505-pcsw3vmx 273 18 for for IN cord-273505-pcsw3vmx 273 19 treatment treatment NN cord-273505-pcsw3vmx 273 20 of of IN cord-273505-pcsw3vmx 273 21 RSV RSV NNP cord-273505-pcsw3vmx 273 22 infections infection NNS cord-273505-pcsw3vmx 273 23 remains remain VBZ cord-273505-pcsw3vmx 273 24 controversial controversial JJ cord-273505-pcsw3vmx 273 25 ( ( -LRB- cord-273505-pcsw3vmx 273 26 239 239 CD cord-273505-pcsw3vmx 273 27 ) ) -RRB- cord-273505-pcsw3vmx 273 28 . . . cord-273505-pcsw3vmx 274 1 A a DT cord-273505-pcsw3vmx 274 2 study study NN cord-273505-pcsw3vmx 274 3 showed show VBD cord-273505-pcsw3vmx 274 4 that that IN cord-273505-pcsw3vmx 274 5 hypogammaglobulinemia hypogammaglobulinemia NN cord-273505-pcsw3vmx 274 6 was be VBD cord-273505-pcsw3vmx 274 7 a a DT cord-273505-pcsw3vmx 274 8 significant significant JJ cord-273505-pcsw3vmx 274 9 risk risk NN cord-273505-pcsw3vmx 274 10 factor factor NN cord-273505-pcsw3vmx 274 11 for for IN cord-273505-pcsw3vmx 274 12 fatal fatal JJ cord-273505-pcsw3vmx 274 13 outcomes outcome NNS cord-273505-pcsw3vmx 274 14 of of IN cord-273505-pcsw3vmx 274 15 RSV RSV NNP cord-273505-pcsw3vmx 274 16 infections infection NNS cord-273505-pcsw3vmx 274 17 in in IN cord-273505-pcsw3vmx 274 18 a a DT cord-273505-pcsw3vmx 274 19 hematology hematology NN cord-273505-pcsw3vmx 274 20 and and CC cord-273505-pcsw3vmx 274 21 transplant transplant NN cord-273505-pcsw3vmx 274 22 unit unit NN cord-273505-pcsw3vmx 274 23 , , , cord-273505-pcsw3vmx 274 24 and and CC cord-273505-pcsw3vmx 274 25 treatment treatment NN cord-273505-pcsw3vmx 274 26 with with IN cord-273505-pcsw3vmx 274 27 IVIg IVIg NNP cord-273505-pcsw3vmx 274 28 at at IN cord-273505-pcsw3vmx 274 29 regular regular JJ cord-273505-pcsw3vmx 274 30 doses dose NNS cord-273505-pcsw3vmx 274 31 was be VBD cord-273505-pcsw3vmx 274 32 unable unable JJ cord-273505-pcsw3vmx 274 33 to to TO cord-273505-pcsw3vmx 274 34 reverse reverse VB cord-273505-pcsw3vmx 274 35 the the DT cord-273505-pcsw3vmx 274 36 poor poor JJ cord-273505-pcsw3vmx 274 37 prognosis prognosis NN cord-273505-pcsw3vmx 274 38 ( ( -LRB- cord-273505-pcsw3vmx 274 39 230 230 CD cord-273505-pcsw3vmx 274 40 ) ) -RRB- cord-273505-pcsw3vmx 274 41 . . . cord-273505-pcsw3vmx 275 1 By by IN cord-273505-pcsw3vmx 275 2 contrast contrast NN cord-273505-pcsw3vmx 275 3 , , , cord-273505-pcsw3vmx 275 4 oral oral JJ cord-273505-pcsw3vmx 275 5 RBV RBV NNP cord-273505-pcsw3vmx 275 6 in in IN cord-273505-pcsw3vmx 275 7 combination combination NN cord-273505-pcsw3vmx 275 8 with with IN cord-273505-pcsw3vmx 275 9 high high JJ cord-273505-pcsw3vmx 275 10 - - HYPH cord-273505-pcsw3vmx 275 11 dose dose NN cord-273505-pcsw3vmx 275 12 IVIg ivig NN cord-273505-pcsw3vmx 275 13 therapy therapy NN cord-273505-pcsw3vmx 275 14 ( ( -LRB- cord-273505-pcsw3vmx 275 15 rather rather RB cord-273505-pcsw3vmx 275 16 than than IN cord-273505-pcsw3vmx 275 17 lower low JJR cord-273505-pcsw3vmx 275 18 doses dose NNS cord-273505-pcsw3vmx 275 19 ) ) -RRB- cord-273505-pcsw3vmx 275 20 , , , cord-273505-pcsw3vmx 275 21 have have VBP cord-273505-pcsw3vmx 275 22 been be VBN cord-273505-pcsw3vmx 275 23 potentially potentially RB cord-273505-pcsw3vmx 275 24 attributed attribute VBN cord-273505-pcsw3vmx 275 25 to to IN cord-273505-pcsw3vmx 275 26 the the DT cord-273505-pcsw3vmx 275 27 improvement improvement NN cord-273505-pcsw3vmx 275 28 of of IN cord-273505-pcsw3vmx 275 29 survival survival NN cord-273505-pcsw3vmx 275 30 in in IN cord-273505-pcsw3vmx 275 31 RSV RSV NNP cord-273505-pcsw3vmx 275 32 - - HYPH cord-273505-pcsw3vmx 275 33 infected infect VBN cord-273505-pcsw3vmx 275 34 allogeneic allogeneic NN cord-273505-pcsw3vmx 275 35 hematopoietic hematopoietic JJ cord-273505-pcsw3vmx 275 36 stem stem NN cord-273505-pcsw3vmx 275 37 cell cell NN cord-273505-pcsw3vmx 275 38 transplanted transplant VBN cord-273505-pcsw3vmx 275 39 ( ( -LRB- cord-273505-pcsw3vmx 275 40 HSCT HSCT NNP cord-273505-pcsw3vmx 275 41 ) ) -RRB- cord-273505-pcsw3vmx 275 42 patients patient NNS cord-273505-pcsw3vmx 275 43 ( ( -LRB- cord-273505-pcsw3vmx 275 44 231 231 CD cord-273505-pcsw3vmx 275 45 ) ) -RRB- cord-273505-pcsw3vmx 275 46 . . . cord-273505-pcsw3vmx 276 1 The the DT cord-273505-pcsw3vmx 276 2 dosage dosage NN cord-273505-pcsw3vmx 276 3 of of IN cord-273505-pcsw3vmx 276 4 IVIg IVIg NNP cord-273505-pcsw3vmx 276 5 might may MD cord-273505-pcsw3vmx 276 6 be be VB cord-273505-pcsw3vmx 276 7 the the DT cord-273505-pcsw3vmx 276 8 critical critical JJ cord-273505-pcsw3vmx 276 9 factor factor NN cord-273505-pcsw3vmx 276 10 for for IN cord-273505-pcsw3vmx 276 11 efficacy efficacy NN cord-273505-pcsw3vmx 276 12 of of IN cord-273505-pcsw3vmx 276 13 therapy therapy NN cord-273505-pcsw3vmx 276 14 , , , cord-273505-pcsw3vmx 276 15 since since IN cord-273505-pcsw3vmx 276 16 the the DT cord-273505-pcsw3vmx 276 17 combination combination NN cord-273505-pcsw3vmx 276 18 of of IN cord-273505-pcsw3vmx 276 19 high high JJ cord-273505-pcsw3vmx 276 20 - - HYPH cord-273505-pcsw3vmx 276 21 dose dose NN cord-273505-pcsw3vmx 276 22 IVIg ivig NN cord-273505-pcsw3vmx 276 23 and and CC cord-273505-pcsw3vmx 276 24 aerosolized aerosolize VBN cord-273505-pcsw3vmx 276 25 RBV RBV NNP cord-273505-pcsw3vmx 276 26 therapy therapy NN cord-273505-pcsw3vmx 276 27 has have VBZ cord-273505-pcsw3vmx 276 28 also also RB cord-273505-pcsw3vmx 276 29 been be VBN cord-273505-pcsw3vmx 276 30 shown show VBN cord-273505-pcsw3vmx 276 31 to to TO cord-273505-pcsw3vmx 276 32 be be VB cord-273505-pcsw3vmx 276 33 a a DT cord-273505-pcsw3vmx 276 34 safe safe JJ cord-273505-pcsw3vmx 276 35 and and CC cord-273505-pcsw3vmx 276 36 promising promising JJ cord-273505-pcsw3vmx 276 37 approach approach NN cord-273505-pcsw3vmx 276 38 to to TO cord-273505-pcsw3vmx 276 39 prevent prevent VB cord-273505-pcsw3vmx 276 40 progression progression NN cord-273505-pcsw3vmx 276 41 of of IN cord-273505-pcsw3vmx 276 42 RSV RSV NNP cord-273505-pcsw3vmx 276 43 infections infection NNS cord-273505-pcsw3vmx 276 44 immunocompromised immunocompromise VBN cord-273505-pcsw3vmx 276 45 patients patient NNS cord-273505-pcsw3vmx 276 46 ( ( -LRB- cord-273505-pcsw3vmx 276 47 232 232 CD cord-273505-pcsw3vmx 276 48 ) ) -RRB- cord-273505-pcsw3vmx 276 49 . . . cord-273505-pcsw3vmx 277 1 Several several JJ cord-273505-pcsw3vmx 277 2 published publish VBN cord-273505-pcsw3vmx 277 3 studies study NNS cord-273505-pcsw3vmx 277 4 suggest suggest VBP cord-273505-pcsw3vmx 277 5 that that IN cord-273505-pcsw3vmx 277 6 a a DT cord-273505-pcsw3vmx 277 7 combined combine VBN cord-273505-pcsw3vmx 277 8 therapy therapy NN cord-273505-pcsw3vmx 277 9 of of IN cord-273505-pcsw3vmx 277 10 RBV RBV NNP cord-273505-pcsw3vmx 277 11 and and CC cord-273505-pcsw3vmx 277 12 IVIg IVIg NNP cord-273505-pcsw3vmx 277 13 improves improve VBZ cord-273505-pcsw3vmx 277 14 the the DT cord-273505-pcsw3vmx 277 15 outcome outcome NN cord-273505-pcsw3vmx 277 16 of of IN cord-273505-pcsw3vmx 277 17 HSCT HSCT NNP cord-273505-pcsw3vmx 277 18 and and CC cord-273505-pcsw3vmx 277 19 leukemia leukemia NN cord-273505-pcsw3vmx 277 20 patients patient NNS cord-273505-pcsw3vmx 277 21 with with IN cord-273505-pcsw3vmx 277 22 RSV RSV NNP cord-273505-pcsw3vmx 277 23 - - HYPH cord-273505-pcsw3vmx 277 24 URTI URTI NNP cord-273505-pcsw3vmx 277 25 , , , cord-273505-pcsw3vmx 277 26 and and CC cord-273505-pcsw3vmx 277 27 additional additional JJ cord-273505-pcsw3vmx 277 28 recommendations recommendation NNS cord-273505-pcsw3vmx 277 29 are be VBP cord-273505-pcsw3vmx 277 30 given give VBN cord-273505-pcsw3vmx 277 31 for for IN cord-273505-pcsw3vmx 277 32 high high JJ cord-273505-pcsw3vmx 277 33 - - HYPH cord-273505-pcsw3vmx 277 34 risk risk NN cord-273505-pcsw3vmx 277 35 patients patient NNS cord-273505-pcsw3vmx 277 36 with with IN cord-273505-pcsw3vmx 277 37 RSV RSV NNP cord-273505-pcsw3vmx 277 38 - - HYPH cord-273505-pcsw3vmx 277 39 LRTI LRTI NNP cord-273505-pcsw3vmx 277 40 ( ( -LRB- cord-273505-pcsw3vmx 277 41 240 240 CD cord-273505-pcsw3vmx 277 42 ) ) -RRB- cord-273505-pcsw3vmx 277 43 ( ( -LRB- cord-273505-pcsw3vmx 277 44 241 241 CD cord-273505-pcsw3vmx 277 45 ) ) -RRB- cord-273505-pcsw3vmx 277 46 ( ( -LRB- cord-273505-pcsw3vmx 277 47 242 242 CD cord-273505-pcsw3vmx 277 48 ) ) -RRB- cord-273505-pcsw3vmx 277 49 . . . cord-273505-pcsw3vmx 278 1 However however RB cord-273505-pcsw3vmx 278 2 , , , cord-273505-pcsw3vmx 278 3 it -PRON- PRP cord-273505-pcsw3vmx 278 4 is be VBZ cord-273505-pcsw3vmx 278 5 noted note VBN cord-273505-pcsw3vmx 278 6 that that IN cord-273505-pcsw3vmx 278 7 most most JJS cord-273505-pcsw3vmx 278 8 studies study NNS cord-273505-pcsw3vmx 278 9 on on IN cord-273505-pcsw3vmx 278 10 IVIg ivig JJ cord-273505-pcsw3vmx 278 11 efficacy efficacy NN cord-273505-pcsw3vmx 278 12 are be VBP cord-273505-pcsw3vmx 278 13 limited limit VBN cord-273505-pcsw3vmx 278 14 to to IN cord-273505-pcsw3vmx 278 15 pediatric pediatric JJ cord-273505-pcsw3vmx 278 16 or or CC cord-273505-pcsw3vmx 278 17 HSCT HSCT NNP cord-273505-pcsw3vmx 278 18 patients patient NNS cord-273505-pcsw3vmx 278 19 , , , cord-273505-pcsw3vmx 278 20 which which WDT cord-273505-pcsw3vmx 278 21 may may MD cord-273505-pcsw3vmx 278 22 not not RB cord-273505-pcsw3vmx 278 23 explicitly explicitly RB cord-273505-pcsw3vmx 278 24 be be VB cord-273505-pcsw3vmx 278 25 recommended recommend VBN cord-273505-pcsw3vmx 278 26 in in IN cord-273505-pcsw3vmx 278 27 all all DT cord-273505-pcsw3vmx 278 28 situations situation NNS cord-273505-pcsw3vmx 278 29 ( ( -LRB- cord-273505-pcsw3vmx 278 30 243 243 CD cord-273505-pcsw3vmx 278 31 ) ) -RRB- cord-273505-pcsw3vmx 278 32 . . . cord-273505-pcsw3vmx 279 1 In in IN cord-273505-pcsw3vmx 279 2 summary summary NN cord-273505-pcsw3vmx 279 3 , , , cord-273505-pcsw3vmx 279 4 IVIg ivig JJ cord-273505-pcsw3vmx 279 5 therapy therapy NN cord-273505-pcsw3vmx 279 6 exhibits exhibit VBZ cord-273505-pcsw3vmx 279 7 different different JJ cord-273505-pcsw3vmx 279 8 levels level NNS cord-273505-pcsw3vmx 279 9 of of IN cord-273505-pcsw3vmx 279 10 potential potential JJ cord-273505-pcsw3vmx 279 11 clinical clinical JJ cord-273505-pcsw3vmx 279 12 benefits benefit NNS cord-273505-pcsw3vmx 279 13 in in IN cord-273505-pcsw3vmx 279 14 SARS SARS NNP cord-273505-pcsw3vmx 279 15 , , , cord-273505-pcsw3vmx 279 16 MERS MERS NNP cord-273505-pcsw3vmx 279 17 , , , cord-273505-pcsw3vmx 279 18 influenza influenza NN cord-273505-pcsw3vmx 279 19 , , , cord-273505-pcsw3vmx 279 20 and and CC cord-273505-pcsw3vmx 279 21 RSV RSV NNP cord-273505-pcsw3vmx 279 22 infections infection NNS cord-273505-pcsw3vmx 279 23 , , , cord-273505-pcsw3vmx 279 24 though though IN cord-273505-pcsw3vmx 279 25 currently currently RB cord-273505-pcsw3vmx 279 26 there there EX cord-273505-pcsw3vmx 279 27 is be VBZ cord-273505-pcsw3vmx 279 28 no no DT cord-273505-pcsw3vmx 279 29 high high JJ cord-273505-pcsw3vmx 279 30 - - HYPH cord-273505-pcsw3vmx 279 31 level level NN cord-273505-pcsw3vmx 279 32 evidence evidence NN cord-273505-pcsw3vmx 279 33 to to TO cord-273505-pcsw3vmx 279 34 support support VB cord-273505-pcsw3vmx 279 35 IVIg ivig VB cord-273505-pcsw3vmx 279 36 use use NN cord-273505-pcsw3vmx 279 37 in in IN cord-273505-pcsw3vmx 279 38 these these DT cord-273505-pcsw3vmx 279 39 infections infection NNS cord-273505-pcsw3vmx 279 40 . . . cord-273505-pcsw3vmx 280 1 Of of IN cord-273505-pcsw3vmx 280 2 note note NN cord-273505-pcsw3vmx 280 3 , , , cord-273505-pcsw3vmx 280 4 the the DT cord-273505-pcsw3vmx 280 5 presented present VBN cord-273505-pcsw3vmx 280 6 results result NNS cord-273505-pcsw3vmx 280 7 are be VBP cord-273505-pcsw3vmx 280 8 partly partly RB cord-273505-pcsw3vmx 280 9 limited limited JJ cord-273505-pcsw3vmx 280 10 to to IN cord-273505-pcsw3vmx 280 11 pediatric pediatric JJ cord-273505-pcsw3vmx 280 12 and and CC cord-273505-pcsw3vmx 280 13 immunocompromised immunocompromised JJ cord-273505-pcsw3vmx 280 14 patients patient NNS cord-273505-pcsw3vmx 280 15 , , , cord-273505-pcsw3vmx 280 16 and and CC cord-273505-pcsw3vmx 280 17 the the DT cord-273505-pcsw3vmx 280 18 clinical clinical JJ cord-273505-pcsw3vmx 280 19 benefits benefit NNS cord-273505-pcsw3vmx 280 20 of of IN cord-273505-pcsw3vmx 280 21 IVIg ivig JJ cord-273505-pcsw3vmx 280 22 therapy therapy NN cord-273505-pcsw3vmx 280 23 may may MD cord-273505-pcsw3vmx 280 24 vary vary VB cord-273505-pcsw3vmx 280 25 in in IN cord-273505-pcsw3vmx 280 26 different different JJ cord-273505-pcsw3vmx 280 27 patient patient NN cord-273505-pcsw3vmx 280 28 populations population NNS cord-273505-pcsw3vmx 280 29 ( ( -LRB- cord-273505-pcsw3vmx 280 30 e.g. e.g. RB cord-273505-pcsw3vmx 280 31 , , , cord-273505-pcsw3vmx 280 32 infants infant NNS cord-273505-pcsw3vmx 280 33 , , , cord-273505-pcsw3vmx 280 34 the the DT cord-273505-pcsw3vmx 280 35 elderly elderly JJ cord-273505-pcsw3vmx 280 36 , , , cord-273505-pcsw3vmx 280 37 and and CC cord-273505-pcsw3vmx 280 38 immunocompromised immunocompromised JJ cord-273505-pcsw3vmx 280 39 individuals individual NNS cord-273505-pcsw3vmx 280 40 ) ) -RRB- cord-273505-pcsw3vmx 280 41 . . . cord-273505-pcsw3vmx 281 1 It -PRON- PRP cord-273505-pcsw3vmx 281 2 is be VBZ cord-273505-pcsw3vmx 281 3 also also RB cord-273505-pcsw3vmx 281 4 noteworthy noteworthy JJ cord-273505-pcsw3vmx 281 5 that that IN cord-273505-pcsw3vmx 281 6 most most JJS cord-273505-pcsw3vmx 281 7 studies study NNS cord-273505-pcsw3vmx 281 8 for for IN cord-273505-pcsw3vmx 281 9 these these DT cord-273505-pcsw3vmx 281 10 viral viral JJ cord-273505-pcsw3vmx 281 11 infections infection NNS cord-273505-pcsw3vmx 281 12 show show VBP cord-273505-pcsw3vmx 281 13 possible possible JJ cord-273505-pcsw3vmx 281 14 benefits benefit NNS cord-273505-pcsw3vmx 281 15 from from IN cord-273505-pcsw3vmx 281 16 IVIg ivig JJ cord-273505-pcsw3vmx 281 17 therapy therapy NN cord-273505-pcsw3vmx 281 18 at at IN cord-273505-pcsw3vmx 281 19 higher high JJR cord-273505-pcsw3vmx 281 20 doses dose NNS cord-273505-pcsw3vmx 281 21 , , , cord-273505-pcsw3vmx 281 22 which which WDT cord-273505-pcsw3vmx 281 23 indicates indicate VBZ cord-273505-pcsw3vmx 281 24 that that IN cord-273505-pcsw3vmx 281 25 a a DT cord-273505-pcsw3vmx 281 26 high high JJ cord-273505-pcsw3vmx 281 27 dosage dosage NN cord-273505-pcsw3vmx 281 28 might may MD cord-273505-pcsw3vmx 281 29 be be VB cord-273505-pcsw3vmx 281 30 key key JJ cord-273505-pcsw3vmx 281 31 for for IN cord-273505-pcsw3vmx 281 32 clinical clinical JJ cord-273505-pcsw3vmx 281 33 efficacy efficacy NN cord-273505-pcsw3vmx 281 34 . . . cord-273505-pcsw3vmx 282 1 Considering consider VBG cord-273505-pcsw3vmx 282 2 the the DT cord-273505-pcsw3vmx 282 3 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 282 4 effects effect NNS cord-273505-pcsw3vmx 282 5 of of IN cord-273505-pcsw3vmx 282 6 highdose highdose NN cord-273505-pcsw3vmx 282 7 IVIg IVIg NNP cord-273505-pcsw3vmx 282 8 on on IN cord-273505-pcsw3vmx 282 9 the the DT cord-273505-pcsw3vmx 282 10 excessive excessive JJ cord-273505-pcsw3vmx 282 11 immune immune JJ cord-273505-pcsw3vmx 282 12 cascade cascade NN cord-273505-pcsw3vmx 282 13 , , , cord-273505-pcsw3vmx 282 14 high high JJ cord-273505-pcsw3vmx 282 15 - - HYPH cord-273505-pcsw3vmx 282 16 dose dose NN cord-273505-pcsw3vmx 282 17 IVIg ivig NN cord-273505-pcsw3vmx 282 18 therapy therapy NN cord-273505-pcsw3vmx 282 19 , , , cord-273505-pcsw3vmx 282 20 as as IN cord-273505-pcsw3vmx 282 21 stated state VBN cord-273505-pcsw3vmx 282 22 above above RB cord-273505-pcsw3vmx 282 23 , , , cord-273505-pcsw3vmx 282 24 may may MD cord-273505-pcsw3vmx 282 25 be be VB cord-273505-pcsw3vmx 282 26 considered consider VBN cord-273505-pcsw3vmx 282 27 a a DT cord-273505-pcsw3vmx 282 28 potential potential JJ cord-273505-pcsw3vmx 282 29 adjunctive adjunctive JJ cord-273505-pcsw3vmx 282 30 treatment treatment NN cord-273505-pcsw3vmx 282 31 for for IN cord-273505-pcsw3vmx 282 32 severe severe JJ cord-273505-pcsw3vmx 282 33 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 282 34 patients patient NNS cord-273505-pcsw3vmx 282 35 . . . cord-273505-pcsw3vmx 283 1 The the DT cord-273505-pcsw3vmx 283 2 national national JJ cord-273505-pcsw3vmx 283 3 diagnosis diagnosis NN cord-273505-pcsw3vmx 283 4 and and CC cord-273505-pcsw3vmx 283 5 treatment treatment NN cord-273505-pcsw3vmx 283 6 protocol protocol NN cord-273505-pcsw3vmx 283 7 for for IN cord-273505-pcsw3vmx 283 8 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 284 1 ( ( -LRB- cord-273505-pcsw3vmx 284 2 Trial Trial NNP cord-273505-pcsw3vmx 284 3 Version Version NNP cord-273505-pcsw3vmx 284 4 7 7 CD cord-273505-pcsw3vmx 284 5 ) ) -RRB- cord-273505-pcsw3vmx 284 6 and and CC cord-273505-pcsw3vmx 284 7 recommendations recommendation NNS cord-273505-pcsw3vmx 284 8 from from IN cord-273505-pcsw3vmx 284 9 the the DT cord-273505-pcsw3vmx 284 10 Peking Peking NNP cord-273505-pcsw3vmx 284 11 Union Union NNP cord-273505-pcsw3vmx 284 12 Medical Medical NNP cord-273505-pcsw3vmx 284 13 College College NNP cord-273505-pcsw3vmx 284 14 Hospital Hospital NNP cord-273505-pcsw3vmx 284 15 have have VBP cord-273505-pcsw3vmx 284 16 suggested suggest VBN cord-273505-pcsw3vmx 284 17 the the DT cord-273505-pcsw3vmx 284 18 application application NN cord-273505-pcsw3vmx 284 19 of of IN cord-273505-pcsw3vmx 284 20 IVIg ivig JJ cord-273505-pcsw3vmx 284 21 therapy therapy NN cord-273505-pcsw3vmx 284 22 in in IN cord-273505-pcsw3vmx 284 23 severe severe JJ cord-273505-pcsw3vmx 284 24 and and CC cord-273505-pcsw3vmx 284 25 critically critically RB cord-273505-pcsw3vmx 284 26 ill ill RB cord-273505-pcsw3vmx 284 27 COVID-19 covid-19 CD cord-273505-pcsw3vmx 284 28 patients patient NNS cord-273505-pcsw3vmx 284 29 ( ( -LRB- cord-273505-pcsw3vmx 284 30 4 4 CD cord-273505-pcsw3vmx 284 31 , , , cord-273505-pcsw3vmx 284 32 18 18 CD cord-273505-pcsw3vmx 284 33 ) ) -RRB- cord-273505-pcsw3vmx 284 34 . . . cord-273505-pcsw3vmx 285 1 Several several JJ cord-273505-pcsw3vmx 285 2 observational observational JJ cord-273505-pcsw3vmx 285 3 and and CC cord-273505-pcsw3vmx 285 4 interventional interventional JJ cord-273505-pcsw3vmx 285 5 studies study NNS cord-273505-pcsw3vmx 285 6 were be VBD cord-273505-pcsw3vmx 285 7 conducted conduct VBN cord-273505-pcsw3vmx 285 8 to to TO cord-273505-pcsw3vmx 285 9 evaluate evaluate VB cord-273505-pcsw3vmx 285 10 the the DT cord-273505-pcsw3vmx 285 11 efficacy efficacy NN cord-273505-pcsw3vmx 285 12 of of IN cord-273505-pcsw3vmx 285 13 IVIg IVIg NNP cord-273505-pcsw3vmx 285 14 . . . cord-273505-pcsw3vmx 286 1 A a DT cord-273505-pcsw3vmx 286 2 retrospective retrospective JJ cord-273505-pcsw3vmx 286 3 study study NN cord-273505-pcsw3vmx 286 4 ( ( -LRB- cord-273505-pcsw3vmx 286 5 n n NN cord-273505-pcsw3vmx 286 6 = = SYM cord-273505-pcsw3vmx 286 7 58 58 CD cord-273505-pcsw3vmx 286 8 ) ) -RRB- cord-273505-pcsw3vmx 286 9 in in IN cord-273505-pcsw3vmx 286 10 China China NNP cord-273505-pcsw3vmx 286 11 included include VBD cord-273505-pcsw3vmx 286 12 severe severe JJ cord-273505-pcsw3vmx 286 13 and and CC cord-273505-pcsw3vmx 286 14 critical critical JJ cord-273505-pcsw3vmx 286 15 ill ill RB cord-273505-pcsw3vmx 287 1 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 287 2 patients patient NNS cord-273505-pcsw3vmx 287 3 that that WDT cord-273505-pcsw3vmx 287 4 were be VBD cord-273505-pcsw3vmx 287 5 administered administer VBN cord-273505-pcsw3vmx 287 6 IVIg ivig JJ cord-273505-pcsw3vmx 287 7 therapy therapy NN cord-273505-pcsw3vmx 287 8 after after IN cord-273505-pcsw3vmx 287 9 admission admission NN cord-273505-pcsw3vmx 287 10 ( ( -LRB- cord-273505-pcsw3vmx 287 11 219 219 CD cord-273505-pcsw3vmx 287 12 ) ) -RRB- cord-273505-pcsw3vmx 287 13 . . . cord-273505-pcsw3vmx 288 1 IVIg IVIg NNP cord-273505-pcsw3vmx 288 2 therapy therapy NN cord-273505-pcsw3vmx 288 3 was be VBD cord-273505-pcsw3vmx 288 4 given give VBN cord-273505-pcsw3vmx 288 5 at at IN cord-273505-pcsw3vmx 288 6 20 20 CD cord-273505-pcsw3vmx 288 7 g g NN cord-273505-pcsw3vmx 288 8 daily daily NN cord-273505-pcsw3vmx 288 9 , , , cord-273505-pcsw3vmx 288 10 and and CC cord-273505-pcsw3vmx 288 11 23 23 CD cord-273505-pcsw3vmx 288 12 of of IN cord-273505-pcsw3vmx 288 13 58 58 CD cord-273505-pcsw3vmx 288 14 ( ( -LRB- cord-273505-pcsw3vmx 288 15 39.6 39.6 CD cord-273505-pcsw3vmx 288 16 % % NN cord-273505-pcsw3vmx 288 17 ) ) -RRB- cord-273505-pcsw3vmx 288 18 patients patient NNS cord-273505-pcsw3vmx 288 19 died die VBD cord-273505-pcsw3vmx 288 20 within within IN cord-273505-pcsw3vmx 288 21 28 28 CD cord-273505-pcsw3vmx 288 22 days day NNS cord-273505-pcsw3vmx 288 23 . . . cord-273505-pcsw3vmx 289 1 For for IN cord-273505-pcsw3vmx 289 2 retrospective retrospective JJ cord-273505-pcsw3vmx 289 3 analysis analysis NN cord-273505-pcsw3vmx 289 4 , , , cord-273505-pcsw3vmx 289 5 patients patient NNS cord-273505-pcsw3vmx 289 6 were be VBD cord-273505-pcsw3vmx 289 7 split split VBN cord-273505-pcsw3vmx 289 8 into into IN cord-273505-pcsw3vmx 289 9 two two CD cord-273505-pcsw3vmx 289 10 groups group NNS cord-273505-pcsw3vmx 289 11 , , , cord-273505-pcsw3vmx 289 12 based base VBN cord-273505-pcsw3vmx 289 13 on on IN cord-273505-pcsw3vmx 289 14 whether whether IN cord-273505-pcsw3vmx 289 15 they -PRON- PRP cord-273505-pcsw3vmx 289 16 received receive VBD cord-273505-pcsw3vmx 289 17 IVIg IVIg NNP cord-273505-pcsw3vmx 289 18 administration administration NN cord-273505-pcsw3vmx 289 19 within within IN cord-273505-pcsw3vmx 289 20 or or CC cord-273505-pcsw3vmx 289 21 after after IN cord-273505-pcsw3vmx 289 22 48 48 CD cord-273505-pcsw3vmx 289 23 h h NN cord-273505-pcsw3vmx 289 24 of of IN cord-273505-pcsw3vmx 289 25 admission admission NN cord-273505-pcsw3vmx 289 26 to to IN cord-273505-pcsw3vmx 289 27 the the DT cord-273505-pcsw3vmx 289 28 intensive intensive JJ cord-273505-pcsw3vmx 289 29 care care NN cord-273505-pcsw3vmx 289 30 unit unit NN cord-273505-pcsw3vmx 289 31 ( ( -LRB- cord-273505-pcsw3vmx 289 32 ICU ICU NNP cord-273505-pcsw3vmx 289 33 ) ) -RRB- cord-273505-pcsw3vmx 289 34 . . . cord-273505-pcsw3vmx 290 1 The the DT cord-273505-pcsw3vmx 290 2 results result NNS cord-273505-pcsw3vmx 290 3 showed show VBD cord-273505-pcsw3vmx 290 4 that that IN cord-273505-pcsw3vmx 290 5 application application NN cord-273505-pcsw3vmx 290 6 of of IN cord-273505-pcsw3vmx 290 7 IVIg IVIg NNP cord-273505-pcsw3vmx 290 8 within within IN cord-273505-pcsw3vmx 290 9 48 48 CD cord-273505-pcsw3vmx 290 10 h h NN cord-273505-pcsw3vmx 290 11 of of IN cord-273505-pcsw3vmx 290 12 admission admission NN cord-273505-pcsw3vmx 290 13 to to IN cord-273505-pcsw3vmx 290 14 ICU ICU NNP cord-273505-pcsw3vmx 290 15 reduced reduce VBD cord-273505-pcsw3vmx 290 16 the the DT cord-273505-pcsw3vmx 290 17 use use NN cord-273505-pcsw3vmx 290 18 of of IN cord-273505-pcsw3vmx 290 19 mechanical mechanical JJ cord-273505-pcsw3vmx 290 20 ventilation ventilation NN cord-273505-pcsw3vmx 290 21 , , , cord-273505-pcsw3vmx 290 22 shortened shorten VBN cord-273505-pcsw3vmx 290 23 duration duration NN cord-273505-pcsw3vmx 290 24 of of IN cord-273505-pcsw3vmx 290 25 ICU ICU NNP cord-273505-pcsw3vmx 290 26 and and CC cord-273505-pcsw3vmx 290 27 hospital hospital NN cord-273505-pcsw3vmx 290 28 stay stay NN cord-273505-pcsw3vmx 290 29 , , , cord-273505-pcsw3vmx 290 30 and and CC cord-273505-pcsw3vmx 290 31 improved improve VBN cord-273505-pcsw3vmx 290 32 28-day 28-day CD cord-273505-pcsw3vmx 290 33 survival survival NN cord-273505-pcsw3vmx 290 34 ( ( -LRB- cord-273505-pcsw3vmx 290 35 219 219 CD cord-273505-pcsw3vmx 290 36 ) ) -RRB- cord-273505-pcsw3vmx 290 37 . . . cord-273505-pcsw3vmx 291 1 The the DT cord-273505-pcsw3vmx 291 2 28-day 28-day CD cord-273505-pcsw3vmx 291 3 mortality mortality NN cord-273505-pcsw3vmx 291 4 of of IN cord-273505-pcsw3vmx 291 5 the the DT cord-273505-pcsw3vmx 291 6 two two CD cord-273505-pcsw3vmx 291 7 groups group NNS cord-273505-pcsw3vmx 291 8 ( ( -LRB- cord-273505-pcsw3vmx 291 9 IVIg ivig VBP cord-273505-pcsw3vmx 291 10 within within IN cord-273505-pcsw3vmx 291 11 or or CC cord-273505-pcsw3vmx 291 12 after after IN cord-273505-pcsw3vmx 291 13 48 48 CD cord-273505-pcsw3vmx 291 14 h h NN cord-273505-pcsw3vmx 291 15 ) ) -RRB- cord-273505-pcsw3vmx 291 16 was be VBD cord-273505-pcsw3vmx 291 17 23.3 23.3 CD cord-273505-pcsw3vmx 291 18 % % NN cord-273505-pcsw3vmx 291 19 ( ( -LRB- cord-273505-pcsw3vmx 291 20 within within IN cord-273505-pcsw3vmx 291 21 48 48 CD cord-273505-pcsw3vmx 291 22 h h NN cord-273505-pcsw3vmx 291 23 ) ) -RRB- cord-273505-pcsw3vmx 291 24 and and CC cord-273505-pcsw3vmx 291 25 57.1 57.1 CD cord-273505-pcsw3vmx 291 26 % % NN cord-273505-pcsw3vmx 291 27 ( ( -LRB- cord-273505-pcsw3vmx 291 28 after after IN cord-273505-pcsw3vmx 291 29 48 48 CD cord-273505-pcsw3vmx 291 30 h h NN cord-273505-pcsw3vmx 291 31 ) ) -RRB- cord-273505-pcsw3vmx 291 32 , , , cord-273505-pcsw3vmx 291 33 indicating indicate VBG cord-273505-pcsw3vmx 291 34 that that IN cord-273505-pcsw3vmx 291 35 early early JJ cord-273505-pcsw3vmx 291 36 initiation initiation NN cord-273505-pcsw3vmx 291 37 of of IN cord-273505-pcsw3vmx 291 38 high high JJ cord-273505-pcsw3vmx 291 39 - - HYPH cord-273505-pcsw3vmx 291 40 dose dose NN cord-273505-pcsw3vmx 291 41 IVIg ivig NN cord-273505-pcsw3vmx 291 42 therapy therapy NN cord-273505-pcsw3vmx 291 43 may may MD cord-273505-pcsw3vmx 291 44 be be VB cord-273505-pcsw3vmx 291 45 beneficial beneficial JJ cord-273505-pcsw3vmx 291 46 in in IN cord-273505-pcsw3vmx 291 47 severe severe JJ cord-273505-pcsw3vmx 291 48 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 291 49 patients patient NNS cord-273505-pcsw3vmx 291 50 . . . cord-273505-pcsw3vmx 292 1 On on IN cord-273505-pcsw3vmx 292 2 the the DT cord-273505-pcsw3vmx 292 3 contrary contrary NN cord-273505-pcsw3vmx 292 4 , , , cord-273505-pcsw3vmx 292 5 there there EX cord-273505-pcsw3vmx 292 6 were be VBD cord-273505-pcsw3vmx 292 7 no no DT cord-273505-pcsw3vmx 292 8 significant significant JJ cord-273505-pcsw3vmx 292 9 effects effect NNS cord-273505-pcsw3vmx 292 10 of of IN cord-273505-pcsw3vmx 292 11 IVIg ivig JJ cord-273505-pcsw3vmx 292 12 therapy therapy NN cord-273505-pcsw3vmx 292 13 on on IN cord-273505-pcsw3vmx 292 14 the the DT cord-273505-pcsw3vmx 292 15 survival survival NN cord-273505-pcsw3vmx 292 16 of of IN cord-273505-pcsw3vmx 292 17 severe severe JJ cord-273505-pcsw3vmx 292 18 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 292 19 patients patient NNS cord-273505-pcsw3vmx 292 20 who who WP cord-273505-pcsw3vmx 292 21 developed develop VBD cord-273505-pcsw3vmx 292 22 ARDS ARDS NNP cord-273505-pcsw3vmx 292 23 in in IN cord-273505-pcsw3vmx 292 24 another another DT cord-273505-pcsw3vmx 292 25 study study NN cord-273505-pcsw3vmx 292 26 ; ; : cord-273505-pcsw3vmx 292 27 here here RB cord-273505-pcsw3vmx 292 28 , , , cord-273505-pcsw3vmx 292 29 the the DT cord-273505-pcsw3vmx 292 30 insufficient insufficient JJ cord-273505-pcsw3vmx 292 31 effects effect NNS cord-273505-pcsw3vmx 292 32 of of IN cord-273505-pcsw3vmx 292 33 IVIg ivig JJ cord-273505-pcsw3vmx 292 34 therapy therapy NN cord-273505-pcsw3vmx 292 35 may may MD cord-273505-pcsw3vmx 292 36 potentially potentially RB cord-273505-pcsw3vmx 292 37 be be VB cord-273505-pcsw3vmx 292 38 a a DT cord-273505-pcsw3vmx 292 39 result result NN cord-273505-pcsw3vmx 292 40 of of IN cord-273505-pcsw3vmx 292 41 timing timing NN cord-273505-pcsw3vmx 292 42 and and CC cord-273505-pcsw3vmx 292 43 dosage dosage NN cord-273505-pcsw3vmx 292 44 of of IN cord-273505-pcsw3vmx 292 45 IVIg IVIg NNP cord-273505-pcsw3vmx 292 46 administration administration NNP cord-273505-pcsw3vmx 292 47 ( ( -LRB- cord-273505-pcsw3vmx 292 48 220 220 CD cord-273505-pcsw3vmx 292 49 ) ) -RRB- cord-273505-pcsw3vmx 292 50 . . . cord-273505-pcsw3vmx 293 1 In in IN cord-273505-pcsw3vmx 293 2 another another DT cord-273505-pcsw3vmx 293 3 study study NN cord-273505-pcsw3vmx 293 4 , , , cord-273505-pcsw3vmx 293 5 a a DT cord-273505-pcsw3vmx 293 6 combination combination NN cord-273505-pcsw3vmx 293 7 therapy therapy NN cord-273505-pcsw3vmx 293 8 of of IN cord-273505-pcsw3vmx 293 9 a a DT cord-273505-pcsw3vmx 293 10 high high JJ cord-273505-pcsw3vmx 293 11 dose dose NN cord-273505-pcsw3vmx 293 12 of of IN cord-273505-pcsw3vmx 293 13 IVIg IVIg NNP cord-273505-pcsw3vmx 293 14 ( ( -LRB- cord-273505-pcsw3vmx 293 15 20 20 CD cord-273505-pcsw3vmx 293 16 g g NN cord-273505-pcsw3vmx 293 17 / / SYM cord-273505-pcsw3vmx 293 18 d d NN cord-273505-pcsw3vmx 293 19 ) ) -RRB- cord-273505-pcsw3vmx 293 20 and and CC cord-273505-pcsw3vmx 293 21 corticosteroid corticosteroid NNP cord-273505-pcsw3vmx 293 22 ( ( -LRB- cord-273505-pcsw3vmx 293 23 160 160 CD cord-273505-pcsw3vmx 293 24 mg mg NNP cord-273505-pcsw3vmx 293 25 / / SYM cord-273505-pcsw3vmx 293 26 d d NN cord-273505-pcsw3vmx 293 27 ) ) -RRB- cord-273505-pcsw3vmx 293 28 succeeded succeed VBD cord-273505-pcsw3vmx 293 29 in in IN cord-273505-pcsw3vmx 293 30 reversing reverse VBG cord-273505-pcsw3vmx 293 31 the the DT cord-273505-pcsw3vmx 293 32 deteriorating deteriorate VBG cord-273505-pcsw3vmx 293 33 condition condition NN cord-273505-pcsw3vmx 293 34 of of IN cord-273505-pcsw3vmx 293 35 severe severe JJ cord-273505-pcsw3vmx 293 36 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 293 37 patients patient NNS cord-273505-pcsw3vmx 293 38 who who WP cord-273505-pcsw3vmx 293 39 had have VBD cord-273505-pcsw3vmx 293 40 previously previously RB cord-273505-pcsw3vmx 293 41 failed fail VBN cord-273505-pcsw3vmx 293 42 low low JJ cord-273505-pcsw3vmx 293 43 - - HYPH cord-273505-pcsw3vmx 293 44 dose dose NN cord-273505-pcsw3vmx 293 45 IVIg IVIg NNS cord-273505-pcsw3vmx 293 46 ( ( -LRB- cord-273505-pcsw3vmx 293 47 10 10 CD cord-273505-pcsw3vmx 293 48 g g NN cord-273505-pcsw3vmx 293 49 / / SYM cord-273505-pcsw3vmx 293 50 d d NN cord-273505-pcsw3vmx 293 51 ) ) -RRB- cord-273505-pcsw3vmx 293 52 and and CC cord-273505-pcsw3vmx 293 53 corticosteroid corticosteroid NN cord-273505-pcsw3vmx 293 54 treatment treatment NN cord-273505-pcsw3vmx 293 55 ( ( -LRB- cord-273505-pcsw3vmx 293 56 221 221 CD cord-273505-pcsw3vmx 293 57 ) ) -RRB- cord-273505-pcsw3vmx 293 58 . . . cord-273505-pcsw3vmx 294 1 However however RB cord-273505-pcsw3vmx 294 2 , , , cord-273505-pcsw3vmx 294 3 as as IN cord-273505-pcsw3vmx 294 4 this this DT cord-273505-pcsw3vmx 294 5 study study NN cord-273505-pcsw3vmx 294 6 investigated investigate VBD cord-273505-pcsw3vmx 294 7 a a DT cord-273505-pcsw3vmx 294 8 combined combine VBN cord-273505-pcsw3vmx 294 9 therapy therapy NN cord-273505-pcsw3vmx 294 10 , , , cord-273505-pcsw3vmx 294 11 it -PRON- PRP cord-273505-pcsw3vmx 294 12 is be VBZ cord-273505-pcsw3vmx 294 13 not not RB cord-273505-pcsw3vmx 294 14 possible possible JJ cord-273505-pcsw3vmx 294 15 to to TO cord-273505-pcsw3vmx 294 16 estimate estimate VB cord-273505-pcsw3vmx 294 17 the the DT cord-273505-pcsw3vmx 294 18 exact exact JJ cord-273505-pcsw3vmx 294 19 effect effect NN cord-273505-pcsw3vmx 294 20 of of IN cord-273505-pcsw3vmx 294 21 high high JJ cord-273505-pcsw3vmx 294 22 IVIg ivig JJ cord-273505-pcsw3vmx 294 23 doses dose NNS cord-273505-pcsw3vmx 294 24 in in IN cord-273505-pcsw3vmx 294 25 this this DT cord-273505-pcsw3vmx 294 26 group group NN cord-273505-pcsw3vmx 294 27 of of IN cord-273505-pcsw3vmx 294 28 patients patient NNS cord-273505-pcsw3vmx 294 29 . . . cord-273505-pcsw3vmx 295 1 The the DT cord-273505-pcsw3vmx 295 2 administration administration NN cord-273505-pcsw3vmx 295 3 of of IN cord-273505-pcsw3vmx 295 4 IVIg IVIg NNP cord-273505-pcsw3vmx 295 5 therapy therapy NN cord-273505-pcsw3vmx 295 6 ( ( -LRB- cord-273505-pcsw3vmx 295 7 25 25 CD cord-273505-pcsw3vmx 295 8 g g NN cord-273505-pcsw3vmx 295 9 / / SYM cord-273505-pcsw3vmx 295 10 d d NN cord-273505-pcsw3vmx 295 11 for for IN cord-273505-pcsw3vmx 295 12 5 5 CD cord-273505-pcsw3vmx 295 13 days day NNS cord-273505-pcsw3vmx 295 14 ) ) -RRB- cord-273505-pcsw3vmx 295 15 at at IN cord-273505-pcsw3vmx 295 16 the the DT cord-273505-pcsw3vmx 295 17 time time NN cord-273505-pcsw3vmx 295 18 of of IN cord-273505-pcsw3vmx 295 19 initiation initiation NN cord-273505-pcsw3vmx 295 20 of of IN cord-273505-pcsw3vmx 295 21 respiratory respiratory JJ cord-273505-pcsw3vmx 295 22 distress distress NN cord-273505-pcsw3vmx 295 23 of of IN cord-273505-pcsw3vmx 295 24 severe severe JJ cord-273505-pcsw3vmx 295 25 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 295 26 patients patient NNS cord-273505-pcsw3vmx 295 27 may may MD cord-273505-pcsw3vmx 295 28 improve improve VB cord-273505-pcsw3vmx 295 29 the the DT cord-273505-pcsw3vmx 295 30 prognosis prognosis NN cord-273505-pcsw3vmx 295 31 ( ( -LRB- cord-273505-pcsw3vmx 295 32 16 16 CD cord-273505-pcsw3vmx 295 33 ) ) -RRB- cord-273505-pcsw3vmx 295 34 . . . cord-273505-pcsw3vmx 296 1 It -PRON- PRP cord-273505-pcsw3vmx 296 2 is be VBZ cord-273505-pcsw3vmx 296 3 noted note VBN cord-273505-pcsw3vmx 296 4 that that IN cord-273505-pcsw3vmx 296 5 only only RB cord-273505-pcsw3vmx 296 6 one one CD cord-273505-pcsw3vmx 296 7 of of IN cord-273505-pcsw3vmx 296 8 three three CD cord-273505-pcsw3vmx 296 9 patients patient NNS cord-273505-pcsw3vmx 296 10 received receive VBD cord-273505-pcsw3vmx 296 11 corticosteroids corticosteroid NNS cord-273505-pcsw3vmx 296 12 , , , cord-273505-pcsw3vmx 296 13 and and CC cord-273505-pcsw3vmx 296 14 these these DT cord-273505-pcsw3vmx 296 15 observations observation NNS cord-273505-pcsw3vmx 296 16 suggest suggest VBP cord-273505-pcsw3vmx 296 17 that that IN cord-273505-pcsw3vmx 296 18 high high JJ cord-273505-pcsw3vmx 296 19 - - HYPH cord-273505-pcsw3vmx 296 20 dose dose NN cord-273505-pcsw3vmx 296 21 IVIg ivig NN cord-273505-pcsw3vmx 296 22 therapy therapy NN cord-273505-pcsw3vmx 296 23 may may MD cord-273505-pcsw3vmx 296 24 be be VB cord-273505-pcsw3vmx 296 25 the the DT cord-273505-pcsw3vmx 296 26 main main JJ cord-273505-pcsw3vmx 296 27 contributor contributor NN cord-273505-pcsw3vmx 296 28 to to IN cord-273505-pcsw3vmx 296 29 successful successful JJ cord-273505-pcsw3vmx 296 30 recovery recovery NN cord-273505-pcsw3vmx 296 31 from from IN cord-273505-pcsw3vmx 296 32 deteriorating deteriorate VBG cord-273505-pcsw3vmx 296 33 conditions condition NNS cord-273505-pcsw3vmx 296 34 . . . cord-273505-pcsw3vmx 297 1 However however RB cord-273505-pcsw3vmx 297 2 , , , cord-273505-pcsw3vmx 297 3 more more RBR cord-273505-pcsw3vmx 297 4 controlled control VBN cord-273505-pcsw3vmx 297 5 trials trial NNS cord-273505-pcsw3vmx 297 6 of of IN cord-273505-pcsw3vmx 297 7 IVIg IVIg NNP cord-273505-pcsw3vmx 297 8 therapy therapy NN cord-273505-pcsw3vmx 297 9 are be VBP cord-273505-pcsw3vmx 297 10 needed need VBN cord-273505-pcsw3vmx 297 11 to to TO cord-273505-pcsw3vmx 297 12 provide provide VB cord-273505-pcsw3vmx 297 13 strong strong JJ cord-273505-pcsw3vmx 297 14 evidence evidence NN cord-273505-pcsw3vmx 297 15 for for IN cord-273505-pcsw3vmx 297 16 its -PRON- PRP$ cord-273505-pcsw3vmx 297 17 beneficial beneficial JJ cord-273505-pcsw3vmx 297 18 effects effect NNS cord-273505-pcsw3vmx 297 19 in in IN cord-273505-pcsw3vmx 297 20 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 297 21 . . . cord-273505-pcsw3vmx 298 1 Based base VBN cord-273505-pcsw3vmx 298 2 on on IN cord-273505-pcsw3vmx 298 3 these these DT cord-273505-pcsw3vmx 298 4 clinical clinical JJ cord-273505-pcsw3vmx 298 5 observations observation NNS cord-273505-pcsw3vmx 298 6 , , , cord-273505-pcsw3vmx 298 7 the the DT cord-273505-pcsw3vmx 298 8 administration administration NN cord-273505-pcsw3vmx 298 9 of of IN cord-273505-pcsw3vmx 298 10 high high JJ cord-273505-pcsw3vmx 298 11 - - HYPH cord-273505-pcsw3vmx 298 12 dose dose NN cord-273505-pcsw3vmx 298 13 IVIg ivig NN cord-273505-pcsw3vmx 298 14 therapy therapy NN cord-273505-pcsw3vmx 298 15 at at IN cord-273505-pcsw3vmx 298 16 the the DT cord-273505-pcsw3vmx 298 17 appropriate appropriate JJ cord-273505-pcsw3vmx 298 18 point point NN cord-273505-pcsw3vmx 298 19 may may MD cord-273505-pcsw3vmx 298 20 be be VB cord-273505-pcsw3vmx 298 21 able able JJ cord-273505-pcsw3vmx 298 22 to to TO cord-273505-pcsw3vmx 298 23 prevent prevent VB cord-273505-pcsw3vmx 298 24 disease disease NN cord-273505-pcsw3vmx 298 25 progression progression NN cord-273505-pcsw3vmx 298 26 and and CC cord-273505-pcsw3vmx 298 27 improve improve VB cord-273505-pcsw3vmx 298 28 the the DT cord-273505-pcsw3vmx 298 29 prognosis prognosis NN cord-273505-pcsw3vmx 298 30 of of IN cord-273505-pcsw3vmx 298 31 patients patient NNS cord-273505-pcsw3vmx 298 32 with with IN cord-273505-pcsw3vmx 298 33 severe severe JJ cord-273505-pcsw3vmx 298 34 COVID-19 covid-19 NN cord-273505-pcsw3vmx 298 35 . . . cord-273505-pcsw3vmx 299 1 Currently currently RB cord-273505-pcsw3vmx 299 2 ongoing ongoing JJ cord-273505-pcsw3vmx 299 3 randomized randomized JJ cord-273505-pcsw3vmx 299 4 controlled control VBN cord-273505-pcsw3vmx 299 5 trials trial NNS cord-273505-pcsw3vmx 299 6 of of IN cord-273505-pcsw3vmx 299 7 high high JJ cord-273505-pcsw3vmx 299 8 - - HYPH cord-273505-pcsw3vmx 299 9 dose dose NN cord-273505-pcsw3vmx 299 10 IVIg ivig NN cord-273505-pcsw3vmx 299 11 therapy therapy NN cord-273505-pcsw3vmx 299 12 in in IN cord-273505-pcsw3vmx 299 13 severe severe JJ cord-273505-pcsw3vmx 299 14 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 299 15 patients patient NNS cord-273505-pcsw3vmx 299 16 are be VBP cord-273505-pcsw3vmx 299 17 evaluating evaluate VBG cord-273505-pcsw3vmx 299 18 the the DT cord-273505-pcsw3vmx 299 19 benefit benefit NN cord-273505-pcsw3vmx 299 20 of of IN cord-273505-pcsw3vmx 299 21 IVIg IVIg NNS cord-273505-pcsw3vmx 299 22 compared compare VBN cord-273505-pcsw3vmx 299 23 to to IN cord-273505-pcsw3vmx 299 24 standard standard JJ cord-273505-pcsw3vmx 299 25 care care NN cord-273505-pcsw3vmx 299 26 ( ( -LRB- cord-273505-pcsw3vmx 299 27 NCT04261426 NCT04261426 NNP cord-273505-pcsw3vmx 299 28 and and CC cord-273505-pcsw3vmx 299 29 NCT04350580 NCT04350580 NNP cord-273505-pcsw3vmx 299 30 ) ) -RRB- cord-273505-pcsw3vmx 299 31 and and CC cord-273505-pcsw3vmx 299 32 will will MD cord-273505-pcsw3vmx 299 33 be be VB cord-273505-pcsw3vmx 299 34 able able JJ cord-273505-pcsw3vmx 299 35 to to TO cord-273505-pcsw3vmx 299 36 further further RB cord-273505-pcsw3vmx 299 37 provide provide VB cord-273505-pcsw3vmx 299 38 more more JJR cord-273505-pcsw3vmx 299 39 information information NN cord-273505-pcsw3vmx 299 40 about about IN cord-273505-pcsw3vmx 299 41 the the DT cord-273505-pcsw3vmx 299 42 clinical clinical JJ cord-273505-pcsw3vmx 299 43 effects effect NNS cord-273505-pcsw3vmx 299 44 of of IN cord-273505-pcsw3vmx 299 45 IVIg ivig JJ cord-273505-pcsw3vmx 299 46 therapy therapy NN cord-273505-pcsw3vmx 299 47 in in IN cord-273505-pcsw3vmx 299 48 COVID- covid- NN cord-273505-pcsw3vmx 299 49 19 19 CD cord-273505-pcsw3vmx 299 50 . . . cord-273505-pcsw3vmx 300 1 Although although IN cord-273505-pcsw3vmx 300 2 a a DT cord-273505-pcsw3vmx 300 3 large large JJ cord-273505-pcsw3vmx 300 4 number number NN cord-273505-pcsw3vmx 300 5 of of IN cord-273505-pcsw3vmx 300 6 clinical clinical JJ cord-273505-pcsw3vmx 300 7 trials trial NNS cord-273505-pcsw3vmx 300 8 have have VBP cord-273505-pcsw3vmx 300 9 demonstrated demonstrate VBN cord-273505-pcsw3vmx 300 10 that that IN cord-273505-pcsw3vmx 300 11 IVIg ivig NN cord-273505-pcsw3vmx 300 12 therapy therapy NN cord-273505-pcsw3vmx 300 13 is be VBZ cord-273505-pcsw3vmx 300 14 well well RB cord-273505-pcsw3vmx 300 15 - - HYPH cord-273505-pcsw3vmx 300 16 tolerated tolerate VBN cord-273505-pcsw3vmx 300 17 , , , cord-273505-pcsw3vmx 300 18 various various JJ cord-273505-pcsw3vmx 300 19 side side NN cord-273505-pcsw3vmx 300 20 effects effect NNS cord-273505-pcsw3vmx 300 21 have have VBP cord-273505-pcsw3vmx 300 22 been be VBN cord-273505-pcsw3vmx 300 23 reported report VBN cord-273505-pcsw3vmx 300 24 ( ( -LRB- cord-273505-pcsw3vmx 300 25 244 244 CD cord-273505-pcsw3vmx 300 26 ) ) -RRB- cord-273505-pcsw3vmx 300 27 . . . cord-273505-pcsw3vmx 301 1 The the DT cord-273505-pcsw3vmx 301 2 majority majority NN cord-273505-pcsw3vmx 301 3 of of IN cord-273505-pcsw3vmx 301 4 these these DT cord-273505-pcsw3vmx 301 5 effects effect NNS cord-273505-pcsw3vmx 301 6 are be VBP cord-273505-pcsw3vmx 301 7 mild mild JJ cord-273505-pcsw3vmx 301 8 and and CC cord-273505-pcsw3vmx 301 9 transient transient JJ cord-273505-pcsw3vmx 301 10 , , , cord-273505-pcsw3vmx 301 11 yet yet CC cord-273505-pcsw3vmx 301 12 clinicians clinician NNS cord-273505-pcsw3vmx 301 13 need need VBP cord-273505-pcsw3vmx 301 14 to to TO cord-273505-pcsw3vmx 301 15 be be VB cord-273505-pcsw3vmx 301 16 vigilant vigilant JJ cord-273505-pcsw3vmx 301 17 about about IN cord-273505-pcsw3vmx 301 18 rare rare JJ cord-273505-pcsw3vmx 301 19 but but CC cord-273505-pcsw3vmx 301 20 serious serious JJ cord-273505-pcsw3vmx 301 21 adverse adverse JJ cord-273505-pcsw3vmx 301 22 effects effect NNS cord-273505-pcsw3vmx 301 23 such such JJ cord-273505-pcsw3vmx 301 24 as as IN cord-273505-pcsw3vmx 301 25 aseptic aseptic JJ cord-273505-pcsw3vmx 301 26 meningitis meningitis NN cord-273505-pcsw3vmx 301 27 , , , cord-273505-pcsw3vmx 301 28 renal renal JJ cord-273505-pcsw3vmx 301 29 impairment impairment NN cord-273505-pcsw3vmx 301 30 , , , cord-273505-pcsw3vmx 301 31 thrombosis thrombosis NN cord-273505-pcsw3vmx 301 32 , , , cord-273505-pcsw3vmx 301 33 and and CC cord-273505-pcsw3vmx 301 34 hemolytic hemolytic JJ cord-273505-pcsw3vmx 301 35 anemia anemia NN cord-273505-pcsw3vmx 301 36 ( ( -LRB- cord-273505-pcsw3vmx 301 37 244 244 CD cord-273505-pcsw3vmx 301 38 ) ) -RRB- cord-273505-pcsw3vmx 301 39 . . . cord-273505-pcsw3vmx 302 1 It -PRON- PRP cord-273505-pcsw3vmx 302 2 is be VBZ cord-273505-pcsw3vmx 302 3 noted note VBN cord-273505-pcsw3vmx 302 4 that that IN cord-273505-pcsw3vmx 302 5 thrombosis thrombosis NN cord-273505-pcsw3vmx 302 6 is be VBZ cord-273505-pcsw3vmx 302 7 common common JJ cord-273505-pcsw3vmx 302 8 in in IN cord-273505-pcsw3vmx 302 9 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 302 10 , , , cord-273505-pcsw3vmx 302 11 and and CC cord-273505-pcsw3vmx 302 12 whether whether IN cord-273505-pcsw3vmx 302 13 highdose highdose NN cord-273505-pcsw3vmx 302 14 IVIg ivig NN cord-273505-pcsw3vmx 302 15 therapy therapy NN cord-273505-pcsw3vmx 302 16 would would MD cord-273505-pcsw3vmx 302 17 further far RBR cord-273505-pcsw3vmx 302 18 increase increase VB cord-273505-pcsw3vmx 302 19 the the DT cord-273505-pcsw3vmx 302 20 risk risk NN cord-273505-pcsw3vmx 302 21 of of IN cord-273505-pcsw3vmx 302 22 thrombosis thrombosis NN cord-273505-pcsw3vmx 302 23 remains remain VBZ cord-273505-pcsw3vmx 302 24 unclear unclear JJ cord-273505-pcsw3vmx 302 25 ( ( -LRB- cord-273505-pcsw3vmx 302 26 17 17 CD cord-273505-pcsw3vmx 302 27 , , , cord-273505-pcsw3vmx 302 28 245 245 CD cord-273505-pcsw3vmx 302 29 ) ) -RRB- cord-273505-pcsw3vmx 302 30 . . . cord-273505-pcsw3vmx 303 1 However however RB cord-273505-pcsw3vmx 303 2 , , , cord-273505-pcsw3vmx 303 3 the the DT cord-273505-pcsw3vmx 303 4 combined combined JJ cord-273505-pcsw3vmx 303 5 treatment treatment NN cord-273505-pcsw3vmx 303 6 of of IN cord-273505-pcsw3vmx 303 7 low low JJ cord-273505-pcsw3vmx 303 8 molecular molecular JJ cord-273505-pcsw3vmx 303 9 weight weight NN cord-273505-pcsw3vmx 303 10 heparin heparin NN cord-273505-pcsw3vmx 303 11 and and CC cord-273505-pcsw3vmx 303 12 high high JJ cord-273505-pcsw3vmx 303 13 - - HYPH cord-273505-pcsw3vmx 303 14 dose dose NN cord-273505-pcsw3vmx 303 15 IVIg ivig NN cord-273505-pcsw3vmx 303 16 therapy therapy NN cord-273505-pcsw3vmx 303 17 at at IN cord-273505-pcsw3vmx 303 18 0.3 0.3 CD cord-273505-pcsw3vmx 303 19 - - SYM cord-273505-pcsw3vmx 303 20 0.5 0.5 CD cord-273505-pcsw3vmx 303 21 g g NN cord-273505-pcsw3vmx 303 22 / / SYM cord-273505-pcsw3vmx 303 23 kg kg NN cord-273505-pcsw3vmx 303 24 / / SYM cord-273505-pcsw3vmx 303 25 d d NN cord-273505-pcsw3vmx 303 26 for for IN cord-273505-pcsw3vmx 303 27 5 5 CD cord-273505-pcsw3vmx 303 28 days day NNS cord-273505-pcsw3vmx 303 29 in in IN cord-273505-pcsw3vmx 303 30 the the DT cord-273505-pcsw3vmx 303 31 early early JJ cord-273505-pcsw3vmx 303 32 phase phase NN cord-273505-pcsw3vmx 303 33 has have VBZ cord-273505-pcsw3vmx 303 34 been be VBN cord-273505-pcsw3vmx 303 35 suggested suggest VBN cord-273505-pcsw3vmx 303 36 to to TO cord-273505-pcsw3vmx 303 37 have have VB cord-273505-pcsw3vmx 303 38 proper proper JJ cord-273505-pcsw3vmx 303 39 efficacy efficacy NN cord-273505-pcsw3vmx 303 40 in in IN cord-273505-pcsw3vmx 303 41 treating treat VBG cord-273505-pcsw3vmx 303 42 severe severe JJ cord-273505-pcsw3vmx 303 43 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 303 44 patients patient NNS cord-273505-pcsw3vmx 303 45 ( ( -LRB- cord-273505-pcsw3vmx 303 46 17 17 CD cord-273505-pcsw3vmx 303 47 ) ) -RRB- cord-273505-pcsw3vmx 303 48 . . . cord-273505-pcsw3vmx 304 1 The the DT cord-273505-pcsw3vmx 304 2 IVIg ivig JJ cord-273505-pcsw3vmx 304 3 preparation preparation NN cord-273505-pcsw3vmx 304 4 is be VBZ cord-273505-pcsw3vmx 304 5 a a DT cord-273505-pcsw3vmx 304 6 widely widely RB cord-273505-pcsw3vmx 304 7 used use VBN cord-273505-pcsw3vmx 304 8 pooled pool VBN cord-273505-pcsw3vmx 304 9 human human JJ cord-273505-pcsw3vmx 304 10 blood blood NN cord-273505-pcsw3vmx 304 11 product product NN cord-273505-pcsw3vmx 304 12 that that WDT cord-273505-pcsw3vmx 304 13 can can MD cord-273505-pcsw3vmx 304 14 provide provide VB cord-273505-pcsw3vmx 304 15 passive passive JJ cord-273505-pcsw3vmx 304 16 immunity immunity NN cord-273505-pcsw3vmx 304 17 and and CC cord-273505-pcsw3vmx 304 18 modulate modulate VB cord-273505-pcsw3vmx 304 19 the the DT cord-273505-pcsw3vmx 304 20 immune immune JJ cord-273505-pcsw3vmx 304 21 functions function NNS cord-273505-pcsw3vmx 304 22 . . . cord-273505-pcsw3vmx 305 1 Although although IN cord-273505-pcsw3vmx 305 2 , , , cord-273505-pcsw3vmx 305 3 for for IN cord-273505-pcsw3vmx 305 4 COIVD-19 COIVD-19 VBG cord-273505-pcsw3vmx 305 5 the the DT cord-273505-pcsw3vmx 305 6 pathogenspecific pathogenspecific NN cord-273505-pcsw3vmx 305 7 effects effect NNS cord-273505-pcsw3vmx 305 8 of of IN cord-273505-pcsw3vmx 305 9 IVIg IVIg NNS cord-273505-pcsw3vmx 305 10 are be VBP cord-273505-pcsw3vmx 305 11 not not RB cord-273505-pcsw3vmx 305 12 relevant relevant JJ cord-273505-pcsw3vmx 305 13 yet yet RB cord-273505-pcsw3vmx 305 14 , , , cord-273505-pcsw3vmx 305 15 since since IN cord-273505-pcsw3vmx 305 16 available available JJ cord-273505-pcsw3vmx 305 17 preparations preparation NNS cord-273505-pcsw3vmx 305 18 were be VBD cord-273505-pcsw3vmx 305 19 collected collect VBN cord-273505-pcsw3vmx 305 20 from from IN cord-273505-pcsw3vmx 305 21 healthy healthy JJ cord-273505-pcsw3vmx 305 22 donors donor NNS cord-273505-pcsw3vmx 305 23 without without IN cord-273505-pcsw3vmx 305 24 preexisting preexist VBG cord-273505-pcsw3vmx 305 25 immunity immunity NN cord-273505-pcsw3vmx 305 26 early early RB cord-273505-pcsw3vmx 305 27 before before IN cord-273505-pcsw3vmx 305 28 the the DT cord-273505-pcsw3vmx 305 29 pandemic pandemic NN cord-273505-pcsw3vmx 305 30 began begin VBD cord-273505-pcsw3vmx 305 31 . . . cord-273505-pcsw3vmx 306 1 The the DT cord-273505-pcsw3vmx 306 2 anti anti JJ cord-273505-pcsw3vmx 306 3 - - JJ cord-273505-pcsw3vmx 306 4 inflammatory inflammatory JJ cord-273505-pcsw3vmx 306 5 and and CC cord-273505-pcsw3vmx 306 6 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 306 7 effects effect NNS cord-273505-pcsw3vmx 306 8 on on IN cord-273505-pcsw3vmx 306 9 the the DT cord-273505-pcsw3vmx 306 10 various various JJ cord-273505-pcsw3vmx 306 11 immune immune JJ cord-273505-pcsw3vmx 306 12 cells cell NNS cord-273505-pcsw3vmx 306 13 of of IN cord-273505-pcsw3vmx 306 14 high high JJ cord-273505-pcsw3vmx 306 15 - - HYPH cord-273505-pcsw3vmx 306 16 dose dose NN cord-273505-pcsw3vmx 306 17 IVIg ivig NN cord-273505-pcsw3vmx 306 18 may may MD cord-273505-pcsw3vmx 306 19 account account VB cord-273505-pcsw3vmx 306 20 for for IN cord-273505-pcsw3vmx 306 21 its -PRON- PRP$ cord-273505-pcsw3vmx 306 22 clinical clinical JJ cord-273505-pcsw3vmx 306 23 benefits benefit NNS cord-273505-pcsw3vmx 306 24 . . . cord-273505-pcsw3vmx 307 1 Based base VBN cord-273505-pcsw3vmx 307 2 on on IN cord-273505-pcsw3vmx 307 3 these these DT cord-273505-pcsw3vmx 307 4 potential potential JJ cord-273505-pcsw3vmx 307 5 supportive supportive JJ cord-273505-pcsw3vmx 307 6 F(ab f(ab NN cord-273505-pcsw3vmx 307 7 ) ) -RRB- cord-273505-pcsw3vmx 307 8 ′ ′ CD cord-273505-pcsw3vmx 307 9 2 2 CD cord-273505-pcsw3vmx 307 10 and and CC cord-273505-pcsw3vmx 307 11 Fc Fc NNP cord-273505-pcsw3vmx 307 12 mediated mediate VBD cord-273505-pcsw3vmx 307 13 mechanisms mechanism NNS cord-273505-pcsw3vmx 307 14 and and CC cord-273505-pcsw3vmx 307 15 the the DT cord-273505-pcsw3vmx 307 16 known know VBN cord-273505-pcsw3vmx 307 17 clinical clinical JJ cord-273505-pcsw3vmx 307 18 effects effect NNS cord-273505-pcsw3vmx 307 19 in in IN cord-273505-pcsw3vmx 307 20 treating treat VBG cord-273505-pcsw3vmx 307 21 severe severe JJ cord-273505-pcsw3vmx 307 22 virus virus NN cord-273505-pcsw3vmx 307 23 pneumonia pneumonia NN cord-273505-pcsw3vmx 307 24 such such JJ cord-273505-pcsw3vmx 307 25 as as IN cord-273505-pcsw3vmx 307 26 SARS SARS NNP cord-273505-pcsw3vmx 307 27 , , , cord-273505-pcsw3vmx 307 28 MERS MERS NNP cord-273505-pcsw3vmx 307 29 , , , cord-273505-pcsw3vmx 307 30 influenza influenza NN cord-273505-pcsw3vmx 307 31 , , , cord-273505-pcsw3vmx 307 32 and and CC cord-273505-pcsw3vmx 307 33 RSV RSV NNP cord-273505-pcsw3vmx 307 34 disease disease NN cord-273505-pcsw3vmx 307 35 , , . cord-273505-pcsw3vmx 308 1 the the DT cord-273505-pcsw3vmx 308 2 early early JJ cord-273505-pcsw3vmx 308 3 application application NN cord-273505-pcsw3vmx 308 4 of of IN cord-273505-pcsw3vmx 308 5 high high JJ cord-273505-pcsw3vmx 308 6 - - HYPH cord-273505-pcsw3vmx 308 7 dose dose NN cord-273505-pcsw3vmx 308 8 IVIg ivig NN cord-273505-pcsw3vmx 308 9 therapy therapy NN cord-273505-pcsw3vmx 308 10 may may MD cord-273505-pcsw3vmx 308 11 be be VB cord-273505-pcsw3vmx 308 12 considered consider VBN cord-273505-pcsw3vmx 308 13 in in IN cord-273505-pcsw3vmx 308 14 the the DT cord-273505-pcsw3vmx 308 15 management management NN cord-273505-pcsw3vmx 308 16 of of IN cord-273505-pcsw3vmx 308 17 severe severe JJ cord-273505-pcsw3vmx 308 18 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 308 19 patients patient NNS cord-273505-pcsw3vmx 308 20 . . . cord-273505-pcsw3vmx 309 1 Currently currently RB cord-273505-pcsw3vmx 309 2 , , , cord-273505-pcsw3vmx 309 3 limited limited JJ cord-273505-pcsw3vmx 309 4 clinical clinical JJ cord-273505-pcsw3vmx 309 5 practice practice NN cord-273505-pcsw3vmx 309 6 of of IN cord-273505-pcsw3vmx 309 7 high high JJ cord-273505-pcsw3vmx 309 8 - - HYPH cord-273505-pcsw3vmx 309 9 dose dose NN cord-273505-pcsw3vmx 309 10 IVIg ivig NN cord-273505-pcsw3vmx 309 11 in in IN cord-273505-pcsw3vmx 309 12 treating treat VBG cord-273505-pcsw3vmx 309 13 SARS SARS NNP cord-273505-pcsw3vmx 309 14 - - HYPH cord-273505-pcsw3vmx 309 15 CoV-2 CoV-2 NNP cord-273505-pcsw3vmx 309 16 infection infection NN cord-273505-pcsw3vmx 309 17 has have VBZ cord-273505-pcsw3vmx 309 18 been be VBN cord-273505-pcsw3vmx 309 19 reported report VBN cord-273505-pcsw3vmx 309 20 to to TO cord-273505-pcsw3vmx 309 21 show show VB cord-273505-pcsw3vmx 309 22 potential potential JJ cord-273505-pcsw3vmx 309 23 clinical clinical JJ cord-273505-pcsw3vmx 309 24 benefits benefit NNS cord-273505-pcsw3vmx 309 25 . . . cord-273505-pcsw3vmx 310 1 Still still RB cord-273505-pcsw3vmx 310 2 , , , cord-273505-pcsw3vmx 310 3 more more JJR cord-273505-pcsw3vmx 310 4 research research NN cord-273505-pcsw3vmx 310 5 is be VBZ cord-273505-pcsw3vmx 310 6 needed need VBN cord-273505-pcsw3vmx 310 7 but but CC cord-273505-pcsw3vmx 310 8 these these DT cord-273505-pcsw3vmx 310 9 inferences inference NNS cord-273505-pcsw3vmx 310 10 may may MD cord-273505-pcsw3vmx 310 11 provide provide VB cord-273505-pcsw3vmx 310 12 relevant relevant JJ cord-273505-pcsw3vmx 310 13 and and CC cord-273505-pcsw3vmx 310 14 useful useful JJ cord-273505-pcsw3vmx 310 15 insights insight NNS cord-273505-pcsw3vmx 310 16 and and CC cord-273505-pcsw3vmx 310 17 help help NN cord-273505-pcsw3vmx 310 18 in in IN cord-273505-pcsw3vmx 310 19 confronting confront VBG cord-273505-pcsw3vmx 310 20 the the DT cord-273505-pcsw3vmx 310 21 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 310 22 epidemic epidemic NN cord-273505-pcsw3vmx 310 23 . . . cord-273505-pcsw3vmx 311 1 XL XL NNP cord-273505-pcsw3vmx 311 2 conceived conceive VBD cord-273505-pcsw3vmx 311 3 and and CC cord-273505-pcsw3vmx 311 4 wrote write VBD cord-273505-pcsw3vmx 311 5 the the DT cord-273505-pcsw3vmx 311 6 manuscript manuscript NN cord-273505-pcsw3vmx 311 7 and and CC cord-273505-pcsw3vmx 311 8 prepared prepared JJ cord-273505-pcsw3vmx 311 9 figures figure NNS cord-273505-pcsw3vmx 311 10 . . . cord-273505-pcsw3vmx 312 1 WC WC NNP cord-273505-pcsw3vmx 312 2 and and CC cord-273505-pcsw3vmx 312 3 TL TL NNP cord-273505-pcsw3vmx 312 4 contributed contribute VBD cord-273505-pcsw3vmx 312 5 to to IN cord-273505-pcsw3vmx 312 6 the the DT cord-273505-pcsw3vmx 312 7 modification modification NN cord-273505-pcsw3vmx 312 8 and and CC cord-273505-pcsw3vmx 312 9 revision revision NN cord-273505-pcsw3vmx 312 10 of of IN cord-273505-pcsw3vmx 312 11 the the DT cord-273505-pcsw3vmx 312 12 manuscript manuscript NN cord-273505-pcsw3vmx 312 13 . . . cord-273505-pcsw3vmx 313 1 All all DT cord-273505-pcsw3vmx 313 2 authors author NNS cord-273505-pcsw3vmx 313 3 contributed contribute VBD cord-273505-pcsw3vmx 313 4 to to IN cord-273505-pcsw3vmx 313 5 the the DT cord-273505-pcsw3vmx 313 6 article article NN cord-273505-pcsw3vmx 313 7 and and CC cord-273505-pcsw3vmx 313 8 approved approve VBD cord-273505-pcsw3vmx 313 9 the the DT cord-273505-pcsw3vmx 313 10 submitted submit VBN cord-273505-pcsw3vmx 313 11 version version NN cord-273505-pcsw3vmx 313 12 . . . cord-273505-pcsw3vmx 313 13 _SP cord-273505-pcsw3vmx 314 1 Available available JJ cord-273505-pcsw3vmx 314 2 oline oline NN cord-273505-pcsw3vmx 314 3 at at IN cord-273505-pcsw3vmx 314 4 Clinical clinical JJ cord-273505-pcsw3vmx 314 5 features feature NNS cord-273505-pcsw3vmx 314 6 of of IN cord-273505-pcsw3vmx 314 7 patients patient NNS cord-273505-pcsw3vmx 314 8 infected infect VBN cord-273505-pcsw3vmx 314 9 with with IN cord-273505-pcsw3vmx 314 10 2019 2019 CD cord-273505-pcsw3vmx 314 11 novel novel JJ cord-273505-pcsw3vmx 314 12 coronavirus coronavirus NN cord-273505-pcsw3vmx 314 13 in in IN cord-273505-pcsw3vmx 314 14 Wuhan Wuhan NNP cord-273505-pcsw3vmx 314 15 Current current JJ cord-273505-pcsw3vmx 314 16 drugs drug NNS cord-273505-pcsw3vmx 314 17 with with IN cord-273505-pcsw3vmx 314 18 potential potential NN cord-273505-pcsw3vmx 314 19 for for IN cord-273505-pcsw3vmx 314 20 treatment treatment NN cord-273505-pcsw3vmx 314 21 of of IN cord-273505-pcsw3vmx 314 22 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 314 23 : : : cord-273505-pcsw3vmx 314 24 a a DT cord-273505-pcsw3vmx 314 25 literature literature NN cord-273505-pcsw3vmx 314 26 review review NN cord-273505-pcsw3vmx 314 27 Diagnosis Diagnosis NNP cord-273505-pcsw3vmx 314 28 and and CC cord-273505-pcsw3vmx 314 29 Treatment Treatment NNP cord-273505-pcsw3vmx 314 30 of of IN cord-273505-pcsw3vmx 314 31 Pneumonia Pneumonia NNP cord-273505-pcsw3vmx 314 32 Infected infect VBN cord-273505-pcsw3vmx 314 33 by by IN cord-273505-pcsw3vmx 314 34 Novel Novel NNP cord-273505-pcsw3vmx 314 35 Coronavirus Coronavirus NNP cord-273505-pcsw3vmx 315 1 ( ( -LRB- cord-273505-pcsw3vmx 315 2 Trial Trial NNP cord-273505-pcsw3vmx 315 3 Version Version NNP cord-273505-pcsw3vmx 315 4 Clinical clinical JJ cord-273505-pcsw3vmx 315 5 evidence evidence NN cord-273505-pcsw3vmx 315 6 does do VBZ cord-273505-pcsw3vmx 315 7 not not RB cord-273505-pcsw3vmx 315 8 support support VB cord-273505-pcsw3vmx 315 9 corticosteroid corticosteroid NN cord-273505-pcsw3vmx 315 10 treatment treatment NN cord-273505-pcsw3vmx 315 11 for for IN cord-273505-pcsw3vmx 315 12 2019-nCoV 2019-ncov CD cord-273505-pcsw3vmx 315 13 lung lung NN cord-273505-pcsw3vmx 315 14 injury injury NN cord-273505-pcsw3vmx 316 1 Corticosteroid Corticosteroid NNP cord-273505-pcsw3vmx 316 2 guidance guidance NN cord-273505-pcsw3vmx 316 3 for for IN cord-273505-pcsw3vmx 316 4 pregnancy pregnancy NN cord-273505-pcsw3vmx 316 5 during during IN cord-273505-pcsw3vmx 316 6 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 316 7 pandemic pandemic NN cord-273505-pcsw3vmx 316 8 Remdesivir Remdesivir NNP cord-273505-pcsw3vmx 316 9 in in IN cord-273505-pcsw3vmx 316 10 adults adult NNS cord-273505-pcsw3vmx 316 11 with with IN cord-273505-pcsw3vmx 316 12 severe severe JJ cord-273505-pcsw3vmx 316 13 COVID-19 covid-19 NN cord-273505-pcsw3vmx 316 14 : : : cord-273505-pcsw3vmx 316 15 a a DT cord-273505-pcsw3vmx 316 16 randomised randomised JJ cord-273505-pcsw3vmx 316 17 , , , cord-273505-pcsw3vmx 316 18 double double JJ cord-273505-pcsw3vmx 316 19 - - HYPH cord-273505-pcsw3vmx 316 20 blind blind JJ cord-273505-pcsw3vmx 316 21 , , , cord-273505-pcsw3vmx 316 22 placebo placebo NN cord-273505-pcsw3vmx 316 23 - - HYPH cord-273505-pcsw3vmx 316 24 controlled control VBN cord-273505-pcsw3vmx 316 25 , , , cord-273505-pcsw3vmx 316 26 multicentre multicentre NNP cord-273505-pcsw3vmx 316 27 trial trial NN cord-273505-pcsw3vmx 316 28 Outcomes Outcomes NNPS cord-273505-pcsw3vmx 316 29 of of IN cord-273505-pcsw3vmx 316 30 hydroxychloroquine hydroxychloroquine NN cord-273505-pcsw3vmx 316 31 usage usage NN cord-273505-pcsw3vmx 316 32 in in IN cord-273505-pcsw3vmx 316 33 United United NNP cord-273505-pcsw3vmx 316 34 States States NNP cord-273505-pcsw3vmx 316 35 veterans veteran NNS cord-273505-pcsw3vmx 316 36 hospitalized hospitalize VBN cord-273505-pcsw3vmx 316 37 with with IN cord-273505-pcsw3vmx 316 38 Covid19 Covid19 NNP cord-273505-pcsw3vmx 316 39 Hydroxychloroquine Hydroxychloroquine NNP cord-273505-pcsw3vmx 316 40 in in IN cord-273505-pcsw3vmx 316 41 patients patient NNS cord-273505-pcsw3vmx 316 42 with with IN cord-273505-pcsw3vmx 316 43 mainly mainly RB cord-273505-pcsw3vmx 316 44 mild mild JJ cord-273505-pcsw3vmx 316 45 to to IN cord-273505-pcsw3vmx 316 46 moderate moderate JJ cord-273505-pcsw3vmx 316 47 coronavirus coronavirus NN cord-273505-pcsw3vmx 316 48 disease disease NN cord-273505-pcsw3vmx 316 49 2019 2019 CD cord-273505-pcsw3vmx 316 50 : : : cord-273505-pcsw3vmx 316 51 open open JJ cord-273505-pcsw3vmx 316 52 label label NN cord-273505-pcsw3vmx 316 53 , , , cord-273505-pcsw3vmx 316 54 randomised randomised JJ cord-273505-pcsw3vmx 316 55 controlled control VBN cord-273505-pcsw3vmx 316 56 trial trial NN cord-273505-pcsw3vmx 316 57 Favipiravir Favipiravir NNP cord-273505-pcsw3vmx 316 58 versus versus IN cord-273505-pcsw3vmx 316 59 arbidol arbidol NN cord-273505-pcsw3vmx 316 60 for for IN cord-273505-pcsw3vmx 316 61 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 316 62 : : : cord-273505-pcsw3vmx 316 63 a a DT cord-273505-pcsw3vmx 316 64 randomized randomized JJ cord-273505-pcsw3vmx 316 65 clinical clinical JJ cord-273505-pcsw3vmx 316 66 trial trial NN cord-273505-pcsw3vmx 316 67 . . . cord-273505-pcsw3vmx 317 1 medRxiv medRxiv NNS cord-273505-pcsw3vmx 317 2 A a DT cord-273505-pcsw3vmx 317 3 trial trial NN cord-273505-pcsw3vmx 317 4 of of IN cord-273505-pcsw3vmx 317 5 lopinavirritonavir lopinavirritonavir NNS cord-273505-pcsw3vmx 317 6 in in IN cord-273505-pcsw3vmx 317 7 adults adult NNS cord-273505-pcsw3vmx 317 8 hospitalized hospitalize VBN cord-273505-pcsw3vmx 317 9 with with IN cord-273505-pcsw3vmx 317 10 severe severe JJ cord-273505-pcsw3vmx 317 11 Covid-19 covid-19 NN cord-273505-pcsw3vmx 317 12 The the DT cord-273505-pcsw3vmx 317 13 host host NN cord-273505-pcsw3vmx 317 14 immune immune JJ cord-273505-pcsw3vmx 317 15 response response NN cord-273505-pcsw3vmx 317 16 in in IN cord-273505-pcsw3vmx 317 17 respiratory respiratory JJ cord-273505-pcsw3vmx 317 18 virus virus NN cord-273505-pcsw3vmx 317 19 infection infection NN cord-273505-pcsw3vmx 317 20 : : : cord-273505-pcsw3vmx 317 21 balancing balance VBG cord-273505-pcsw3vmx 317 22 virus virus NN cord-273505-pcsw3vmx 317 23 clearance clearance NN cord-273505-pcsw3vmx 317 24 and and CC cord-273505-pcsw3vmx 317 25 immunopathology immunopathology NN cord-273505-pcsw3vmx 317 26 In in IN cord-273505-pcsw3vmx 317 27 the the DT cord-273505-pcsw3vmx 317 28 eye eye NN cord-273505-pcsw3vmx 317 29 of of IN cord-273505-pcsw3vmx 317 30 the the DT cord-273505-pcsw3vmx 317 31 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 317 32 cytokine cytokine NN cord-273505-pcsw3vmx 317 33 storm storm NN cord-273505-pcsw3vmx 318 1 The the DT cord-273505-pcsw3vmx 318 2 use use NN cord-273505-pcsw3vmx 318 3 of of IN cord-273505-pcsw3vmx 318 4 antiinflammatory antiinflammatory JJ cord-273505-pcsw3vmx 318 5 drugs drug NNS cord-273505-pcsw3vmx 318 6 in in IN cord-273505-pcsw3vmx 318 7 the the DT cord-273505-pcsw3vmx 318 8 treatment treatment NN cord-273505-pcsw3vmx 318 9 of of IN cord-273505-pcsw3vmx 318 10 people people NNS cord-273505-pcsw3vmx 318 11 with with IN cord-273505-pcsw3vmx 318 12 severe severe JJ cord-273505-pcsw3vmx 318 13 coronavirus coronavirus NN cord-273505-pcsw3vmx 318 14 disease disease NN cord-273505-pcsw3vmx 318 15 2019 2019 CD cord-273505-pcsw3vmx 318 16 ( ( -LRB- cord-273505-pcsw3vmx 318 17 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 318 18 ) ) -RRB- cord-273505-pcsw3vmx 318 19 : : : cord-273505-pcsw3vmx 318 20 The the DT cord-273505-pcsw3vmx 318 21 Perspectives perspective NNS cord-273505-pcsw3vmx 318 22 of of IN cord-273505-pcsw3vmx 318 23 clinical clinical JJ cord-273505-pcsw3vmx 318 24 immunologists immunologist NNS cord-273505-pcsw3vmx 318 25 from from IN cord-273505-pcsw3vmx 318 26 China China NNP cord-273505-pcsw3vmx 319 1 The the DT cord-273505-pcsw3vmx 319 2 role role NN cord-273505-pcsw3vmx 319 3 of of IN cord-273505-pcsw3vmx 319 4 adjuvant adjuvant JJ cord-273505-pcsw3vmx 319 5 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 319 6 agents agent NNS cord-273505-pcsw3vmx 319 7 for for IN cord-273505-pcsw3vmx 319 8 treatment treatment NN cord-273505-pcsw3vmx 319 9 of of IN cord-273505-pcsw3vmx 319 10 severe severe JJ cord-273505-pcsw3vmx 319 11 influenza influenza NN cord-273505-pcsw3vmx 319 12 High high JJ cord-273505-pcsw3vmx 319 13 - - HYPH cord-273505-pcsw3vmx 319 14 dose dose NN cord-273505-pcsw3vmx 319 15 intravenous intravenous JJ cord-273505-pcsw3vmx 319 16 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 319 17 as as IN cord-273505-pcsw3vmx 319 18 a a DT cord-273505-pcsw3vmx 319 19 therapeutic therapeutic JJ cord-273505-pcsw3vmx 319 20 option option NN cord-273505-pcsw3vmx 319 21 for for IN cord-273505-pcsw3vmx 319 22 deteriorating deteriorate VBG cord-273505-pcsw3vmx 319 23 patients patient NNS cord-273505-pcsw3vmx 319 24 with with IN cord-273505-pcsw3vmx 319 25 Coronavirus Coronavirus NNP cord-273505-pcsw3vmx 319 26 Disease Disease NNP cord-273505-pcsw3vmx 319 27 Hypothesis Hypothesis NNP cord-273505-pcsw3vmx 319 28 for for IN cord-273505-pcsw3vmx 319 29 potential potential JJ cord-273505-pcsw3vmx 319 30 pathogenesis pathogenesis NN cord-273505-pcsw3vmx 319 31 of of IN cord-273505-pcsw3vmx 319 32 SARS SARS NNP cord-273505-pcsw3vmx 319 33 - - HYPH cord-273505-pcsw3vmx 319 34 CoV-2 CoV-2 NNP cord-273505-pcsw3vmx 319 35 infection infection NN cord-273505-pcsw3vmx 319 36 - - : cord-273505-pcsw3vmx 319 37 a a DT cord-273505-pcsw3vmx 319 38 review review NN cord-273505-pcsw3vmx 319 39 of of IN cord-273505-pcsw3vmx 319 40 immune immune JJ cord-273505-pcsw3vmx 319 41 changes change NNS cord-273505-pcsw3vmx 319 42 in in IN cord-273505-pcsw3vmx 319 43 patients patient NNS cord-273505-pcsw3vmx 319 44 with with IN cord-273505-pcsw3vmx 319 45 viral viral JJ cord-273505-pcsw3vmx 319 46 pneumonia pneumonia NN cord-273505-pcsw3vmx 319 47 Diagnosis diagnosis NN cord-273505-pcsw3vmx 319 48 and and CC cord-273505-pcsw3vmx 319 49 clinical clinical JJ cord-273505-pcsw3vmx 319 50 management management NN cord-273505-pcsw3vmx 319 51 of of IN cord-273505-pcsw3vmx 319 52 severe severe JJ cord-273505-pcsw3vmx 319 53 acute acute JJ cord-273505-pcsw3vmx 319 54 respiratory respiratory JJ cord-273505-pcsw3vmx 319 55 syndrome syndrome NN cord-273505-pcsw3vmx 319 56 Coronavirus Coronavirus NNP cord-273505-pcsw3vmx 319 57 2 2 CD cord-273505-pcsw3vmx 320 1 ( ( -LRB- cord-273505-pcsw3vmx 320 2 SARS SARS NNP cord-273505-pcsw3vmx 320 3 - - HYPH cord-273505-pcsw3vmx 320 4 CoV-2 CoV-2 NNP cord-273505-pcsw3vmx 320 5 ) ) -RRB- cord-273505-pcsw3vmx 320 6 infection infection NN cord-273505-pcsw3vmx 320 7 : : : cord-273505-pcsw3vmx 321 1 an an DT cord-273505-pcsw3vmx 321 2 operational operational JJ cord-273505-pcsw3vmx 321 3 recommendation recommendation NN cord-273505-pcsw3vmx 321 4 of of IN cord-273505-pcsw3vmx 321 5 Peking Peking NNP cord-273505-pcsw3vmx 321 6 Union Union NNP cord-273505-pcsw3vmx 321 7 Medical Medical NNP cord-273505-pcsw3vmx 321 8 College College NNP cord-273505-pcsw3vmx 321 9 Hospital Hospital NNP cord-273505-pcsw3vmx 321 10 Is be VBZ cord-273505-pcsw3vmx 321 11 dosing dosing NN cord-273505-pcsw3vmx 321 12 of of IN cord-273505-pcsw3vmx 321 13 therapeutic therapeutic JJ cord-273505-pcsw3vmx 321 14 immunoglobulins immunoglobulin NNS cord-273505-pcsw3vmx 321 15 optimal optimal JJ cord-273505-pcsw3vmx 321 16 ? ? . cord-273505-pcsw3vmx 322 1 A a DT cord-273505-pcsw3vmx 322 2 review review NN cord-273505-pcsw3vmx 322 3 of of IN cord-273505-pcsw3vmx 322 4 a a DT cord-273505-pcsw3vmx 322 5 three three CD cord-273505-pcsw3vmx 322 6 - - HYPH cord-273505-pcsw3vmx 322 7 decade decade NN cord-273505-pcsw3vmx 322 8 long long JJ cord-273505-pcsw3vmx 322 9 debate debate NN cord-273505-pcsw3vmx 322 10 in in IN cord-273505-pcsw3vmx 322 11 europe europe NNP cord-273505-pcsw3vmx 322 12 Evidence evidence NN cord-273505-pcsw3vmx 322 13 for for IN cord-273505-pcsw3vmx 322 14 the the DT cord-273505-pcsw3vmx 322 15 use use NN cord-273505-pcsw3vmx 322 16 of of IN cord-273505-pcsw3vmx 322 17 intravenous intravenous JJ cord-273505-pcsw3vmx 322 18 immunoglobulins immunoglobulin NNS cord-273505-pcsw3vmx 322 19 - - : cord-273505-pcsw3vmx 322 20 a a DT cord-273505-pcsw3vmx 322 21 review review NN cord-273505-pcsw3vmx 322 22 of of IN cord-273505-pcsw3vmx 322 23 the the DT cord-273505-pcsw3vmx 322 24 literature literature NN cord-273505-pcsw3vmx 322 25 Identification identification NN cord-273505-pcsw3vmx 322 26 of of IN cord-273505-pcsw3vmx 322 27 the the DT cord-273505-pcsw3vmx 322 28 Streptococcus Streptococcus NNP cord-273505-pcsw3vmx 322 29 pyogenes pyogene NNS cord-273505-pcsw3vmx 322 30 surface surface NN cord-273505-pcsw3vmx 322 31 antigens antigen NNS cord-273505-pcsw3vmx 322 32 skin skin NN cord-273505-pcsw3vmx 322 33 blistering blister VBG cord-273505-pcsw3vmx 322 34 diseases disease NNS cord-273505-pcsw3vmx 322 35 Influence influence NN cord-273505-pcsw3vmx 322 36 of of IN cord-273505-pcsw3vmx 322 37 FCRN FCRN NNP cord-273505-pcsw3vmx 322 38 expression expression NN cord-273505-pcsw3vmx 322 39 on on IN cord-273505-pcsw3vmx 322 40 lung lung NN cord-273505-pcsw3vmx 322 41 decline decline NN cord-273505-pcsw3vmx 322 42 and and CC cord-273505-pcsw3vmx 322 43 intravenous intravenous JJ cord-273505-pcsw3vmx 322 44 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 322 45 catabolism catabolism NN cord-273505-pcsw3vmx 322 46 in in IN cord-273505-pcsw3vmx 322 47 common common JJ cord-273505-pcsw3vmx 322 48 variable variable JJ cord-273505-pcsw3vmx 322 49 immunodeficiency immunodeficiency NN cord-273505-pcsw3vmx 322 50 patients patient NNS cord-273505-pcsw3vmx 322 51 Efficiency Efficiency NNP cord-273505-pcsw3vmx 322 52 of of IN cord-273505-pcsw3vmx 322 53 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 322 54 G g NN cord-273505-pcsw3vmx 322 55 replacement replacement NN cord-273505-pcsw3vmx 322 56 therapy therapy NN cord-273505-pcsw3vmx 322 57 in in IN cord-273505-pcsw3vmx 322 58 common common JJ cord-273505-pcsw3vmx 322 59 variable variable JJ cord-273505-pcsw3vmx 322 60 immunodeficiency immunodeficiency NN cord-273505-pcsw3vmx 322 61 : : : cord-273505-pcsw3vmx 322 62 correlations correlation NNS cord-273505-pcsw3vmx 322 63 with with IN cord-273505-pcsw3vmx 322 64 clinical clinical JJ cord-273505-pcsw3vmx 322 65 phenotype phenotype NN cord-273505-pcsw3vmx 322 66 and and CC cord-273505-pcsw3vmx 322 67 polymorphism polymorphism NN cord-273505-pcsw3vmx 322 68 of of IN cord-273505-pcsw3vmx 322 69 the the DT cord-273505-pcsw3vmx 322 70 neonatal neonatal JJ cord-273505-pcsw3vmx 322 71 Fc Fc NNP cord-273505-pcsw3vmx 322 72 receptor receptor NN cord-273505-pcsw3vmx 322 73 Pharmacokinetic Pharmacokinetic NNP cord-273505-pcsw3vmx 322 74 models model NNS cord-273505-pcsw3vmx 322 75 for for IN cord-273505-pcsw3vmx 322 76 FcRn FcRn NNP cord-273505-pcsw3vmx 322 77 - - HYPH cord-273505-pcsw3vmx 322 78 mediated mediate VBN cord-273505-pcsw3vmx 322 79 IgG igg NN cord-273505-pcsw3vmx 322 80 disposition disposition NN cord-273505-pcsw3vmx 322 81 Augmented augment VBN cord-273505-pcsw3vmx 322 82 humoral humoral JJ cord-273505-pcsw3vmx 322 83 and and CC cord-273505-pcsw3vmx 322 84 anaphylactic anaphylactic JJ cord-273505-pcsw3vmx 322 85 responses response NNS cord-273505-pcsw3vmx 322 86 in in IN cord-273505-pcsw3vmx 322 87 Fc Fc NNP cord-273505-pcsw3vmx 322 88 gamma gamma NN cord-273505-pcsw3vmx 322 89 RII rii NN cord-273505-pcsw3vmx 322 90 - - HYPH cord-273505-pcsw3vmx 322 91 deficient deficient JJ cord-273505-pcsw3vmx 322 92 mice mouse NNS cord-273505-pcsw3vmx 323 1 Impaired impaired JJ cord-273505-pcsw3vmx 323 2 inhibitory inhibitory JJ cord-273505-pcsw3vmx 323 3 Fcgamma Fcgamma NNP cord-273505-pcsw3vmx 323 4 receptor receptor NN cord-273505-pcsw3vmx 323 5 IIB IIB NNP cord-273505-pcsw3vmx 323 6 expression expression NN cord-273505-pcsw3vmx 323 7 on on IN cord-273505-pcsw3vmx 323 8 B b NN cord-273505-pcsw3vmx 323 9 cells cell NNS cord-273505-pcsw3vmx 323 10 in in IN cord-273505-pcsw3vmx 323 11 chronic chronic JJ cord-273505-pcsw3vmx 323 12 inflammatory inflammatory JJ cord-273505-pcsw3vmx 323 13 demyelinating demyelinating NN cord-273505-pcsw3vmx 323 14 polyneuropathy polyneuropathy NN cord-273505-pcsw3vmx 323 15 Recapitulation recapitulation NN cord-273505-pcsw3vmx 323 16 of of IN cord-273505-pcsw3vmx 323 17 IVIG IVIG NNP cord-273505-pcsw3vmx 323 18 anti anti JJ cord-273505-pcsw3vmx 323 19 - - JJ cord-273505-pcsw3vmx 323 20 inflammatory inflammatory JJ cord-273505-pcsw3vmx 323 21 activity activity NN cord-273505-pcsw3vmx 323 22 with with IN cord-273505-pcsw3vmx 323 23 a a DT cord-273505-pcsw3vmx 323 24 recombinant recombinant JJ cord-273505-pcsw3vmx 323 25 IgG igg NN cord-273505-pcsw3vmx 323 26 Fc Fc NNP cord-273505-pcsw3vmx 323 27 Identification Identification NNP cord-273505-pcsw3vmx 323 28 of of IN cord-273505-pcsw3vmx 323 29 a a DT cord-273505-pcsw3vmx 323 30 receptor receptor NN cord-273505-pcsw3vmx 323 31 required require VBN cord-273505-pcsw3vmx 323 32 for for IN cord-273505-pcsw3vmx 323 33 the the DT cord-273505-pcsw3vmx 323 34 anti anti JJ cord-273505-pcsw3vmx 323 35 - - JJ cord-273505-pcsw3vmx 323 36 inflammatory inflammatory JJ cord-273505-pcsw3vmx 323 37 activity activity NN cord-273505-pcsw3vmx 323 38 of of IN cord-273505-pcsw3vmx 323 39 IVIG IVIG NNP cord-273505-pcsw3vmx 323 40 Intravenous Intravenous NNP cord-273505-pcsw3vmx 323 41 gammaglobulin gammaglobulin NN cord-273505-pcsw3vmx 323 42 suppresses suppress VBZ cord-273505-pcsw3vmx 323 43 inflammation inflammation NN cord-273505-pcsw3vmx 323 44 through through IN cord-273505-pcsw3vmx 323 45 a a DT cord-273505-pcsw3vmx 323 46 novel novel JJ cord-273505-pcsw3vmx 323 47 T(H)2 t(h)2 NN cord-273505-pcsw3vmx 323 48 pathway pathway NN cord-273505-pcsw3vmx 323 49 Intravenous Intravenous NNP cord-273505-pcsw3vmx 323 50 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 323 51 therapy therapy NN cord-273505-pcsw3vmx 323 52 : : : cord-273505-pcsw3vmx 323 53 how how WRB cord-273505-pcsw3vmx 323 54 does do VBZ cord-273505-pcsw3vmx 323 55 IgG IgG NNP cord-273505-pcsw3vmx 323 56 modulate modulate VB cord-273505-pcsw3vmx 323 57 the the DT cord-273505-pcsw3vmx 323 58 immune immune JJ cord-273505-pcsw3vmx 323 59 system system NN cord-273505-pcsw3vmx 323 60 ? ? . cord-273505-pcsw3vmx 324 1 Dissecting dissect VBG cord-273505-pcsw3vmx 324 2 the the DT cord-273505-pcsw3vmx 324 3 molecular molecular JJ cord-273505-pcsw3vmx 324 4 mechanism mechanism NN cord-273505-pcsw3vmx 324 5 of of IN cord-273505-pcsw3vmx 324 6 IVIg IVIg NNP cord-273505-pcsw3vmx 324 7 therapy therapy NN cord-273505-pcsw3vmx 324 8 : : : cord-273505-pcsw3vmx 324 9 the the DT cord-273505-pcsw3vmx 324 10 interaction interaction NN cord-273505-pcsw3vmx 324 11 between between IN cord-273505-pcsw3vmx 324 12 serum serum NN cord-273505-pcsw3vmx 324 13 IgG IgG NNP cord-273505-pcsw3vmx 324 14 and and CC cord-273505-pcsw3vmx 324 15 DC DC NNP cord-273505-pcsw3vmx 324 16 - - HYPH cord-273505-pcsw3vmx 324 17 SIGN SIGN NNP cord-273505-pcsw3vmx 324 18 is be VBZ cord-273505-pcsw3vmx 324 19 independent independent JJ cord-273505-pcsw3vmx 324 20 of of IN cord-273505-pcsw3vmx 324 21 antibody antibody NN cord-273505-pcsw3vmx 324 22 glycoform glycoform NNP cord-273505-pcsw3vmx 324 23 or or CC cord-273505-pcsw3vmx 324 24 Fc Fc NNP cord-273505-pcsw3vmx 324 25 domain domain NN cord-273505-pcsw3vmx 324 26 Human Human NNP cord-273505-pcsw3vmx 324 27 DC DC NNP cord-273505-pcsw3vmx 324 28 - - HYPH cord-273505-pcsw3vmx 324 29 SIGN sign NN cord-273505-pcsw3vmx 325 1 and and CC cord-273505-pcsw3vmx 325 2 CD23 CD23 NNP cord-273505-pcsw3vmx 325 3 do do VBP cord-273505-pcsw3vmx 325 4 not not RB cord-273505-pcsw3vmx 325 5 interact interact VB cord-273505-pcsw3vmx 325 6 with with IN cord-273505-pcsw3vmx 325 7 human human JJ cord-273505-pcsw3vmx 325 8 DC DC NNP cord-273505-pcsw3vmx 325 9 - - HYPH cord-273505-pcsw3vmx 325 10 SIGN SIGN NNP cord-273505-pcsw3vmx 325 11 and and CC cord-273505-pcsw3vmx 325 12 alpha2,6-sialylated alpha2,6-sialylated JJ cord-273505-pcsw3vmx 325 13 IgG igg NN cord-273505-pcsw3vmx 325 14 Fc Fc NNP cord-273505-pcsw3vmx 325 15 interaction interaction NN cord-273505-pcsw3vmx 326 1 is be VBZ cord-273505-pcsw3vmx 326 2 dispensable dispensable JJ cord-273505-pcsw3vmx 326 3 for for IN cord-273505-pcsw3vmx 326 4 the the DT cord-273505-pcsw3vmx 326 5 anti anti JJ cord-273505-pcsw3vmx 326 6 - - JJ cord-273505-pcsw3vmx 326 7 inflammatory inflammatory JJ cord-273505-pcsw3vmx 326 8 activity activity NN cord-273505-pcsw3vmx 326 9 of of IN cord-273505-pcsw3vmx 326 10 IVIg IVIg NNP cord-273505-pcsw3vmx 326 11 on on IN cord-273505-pcsw3vmx 326 12 human human JJ cord-273505-pcsw3vmx 326 13 dendritic dendritic JJ cord-273505-pcsw3vmx 326 14 cells cell NNS cord-273505-pcsw3vmx 326 15 Analysis Analysis NNP cord-273505-pcsw3vmx 326 16 and and CC cord-273505-pcsw3vmx 326 17 functional functional JJ cord-273505-pcsw3vmx 326 18 consequences consequence NNS cord-273505-pcsw3vmx 326 19 of of IN cord-273505-pcsw3vmx 326 20 increased increase VBN cord-273505-pcsw3vmx 326 21 Fab fab JJ cord-273505-pcsw3vmx 326 22 - - HYPH cord-273505-pcsw3vmx 326 23 sialylation sialylation NN cord-273505-pcsw3vmx 326 24 of of IN cord-273505-pcsw3vmx 326 25 intravenous intravenous JJ cord-273505-pcsw3vmx 326 26 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 326 27 ( ( -LRB- cord-273505-pcsw3vmx 326 28 IVIG IVIG NNP cord-273505-pcsw3vmx 326 29 ) ) -RRB- cord-273505-pcsw3vmx 326 30 after after IN cord-273505-pcsw3vmx 326 31 lectin lectin NN cord-273505-pcsw3vmx 326 32 fractionation fractionation NN cord-273505-pcsw3vmx 326 33 Therapeutic therapeutic JJ cord-273505-pcsw3vmx 326 34 effect effect NN cord-273505-pcsw3vmx 326 35 of of IN cord-273505-pcsw3vmx 326 36 IVIG IVIG NNP cord-273505-pcsw3vmx 326 37 on on IN cord-273505-pcsw3vmx 326 38 inflammatory inflammatory JJ cord-273505-pcsw3vmx 326 39 arthritis arthritis NN cord-273505-pcsw3vmx 326 40 in in IN cord-273505-pcsw3vmx 326 41 mice mice NN cord-273505-pcsw3vmx 326 42 is be VBZ cord-273505-pcsw3vmx 326 43 dependent dependent JJ cord-273505-pcsw3vmx 326 44 on on IN cord-273505-pcsw3vmx 326 45 the the DT cord-273505-pcsw3vmx 326 46 Fc Fc NNP cord-273505-pcsw3vmx 326 47 portion portion NN cord-273505-pcsw3vmx 326 48 and and CC cord-273505-pcsw3vmx 326 49 independent independent JJ cord-273505-pcsw3vmx 326 50 of of IN cord-273505-pcsw3vmx 326 51 sialylation sialylation NN cord-273505-pcsw3vmx 326 52 or or CC cord-273505-pcsw3vmx 327 1 basophils basophils NNP cord-273505-pcsw3vmx 327 2 Inhibition Inhibition NNP cord-273505-pcsw3vmx 327 3 of of IN cord-273505-pcsw3vmx 327 4 FcgammaR FcgammaR NNP cord-273505-pcsw3vmx 327 5 - - HYPH cord-273505-pcsw3vmx 327 6 mediated mediate VBN cord-273505-pcsw3vmx 327 7 phagocytosis phagocytosis NN cord-273505-pcsw3vmx 327 8 by by IN cord-273505-pcsw3vmx 327 9 IVIg IVIg NNP cord-273505-pcsw3vmx 327 10 is be VBZ cord-273505-pcsw3vmx 327 11 independent independent JJ cord-273505-pcsw3vmx 327 12 of of IN cord-273505-pcsw3vmx 327 13 IgG IgG NNP cord-273505-pcsw3vmx 327 14 - - HYPH cord-273505-pcsw3vmx 327 15 Fc Fc NNP cord-273505-pcsw3vmx 327 16 sialylation sialylation NN cord-273505-pcsw3vmx 327 17 and and CC cord-273505-pcsw3vmx 328 1 FcgammaRIIb fcgammariib RB cord-273505-pcsw3vmx 328 2 in in IN cord-273505-pcsw3vmx 328 3 human human JJ cord-273505-pcsw3vmx 328 4 macrophages macrophage NNS cord-273505-pcsw3vmx 328 5 Sialylation sialylation NN cord-273505-pcsw3vmx 328 6 - - HYPH cord-273505-pcsw3vmx 328 7 independent independent JJ cord-273505-pcsw3vmx 328 8 mechanism mechanism NN cord-273505-pcsw3vmx 328 9 involved involve VBN cord-273505-pcsw3vmx 328 10 in in IN cord-273505-pcsw3vmx 328 11 the the DT cord-273505-pcsw3vmx 328 12 amelioration amelioration NN cord-273505-pcsw3vmx 328 13 of of IN cord-273505-pcsw3vmx 328 14 murine murine JJ cord-273505-pcsw3vmx 328 15 immune immune JJ cord-273505-pcsw3vmx 328 16 thrombocytopenia thrombocytopenia NN cord-273505-pcsw3vmx 328 17 using use VBG cord-273505-pcsw3vmx 328 18 intravenous intravenous JJ cord-273505-pcsw3vmx 328 19 gammaglobulin gammaglobulin NNP cord-273505-pcsw3vmx 328 20 High high JJ cord-273505-pcsw3vmx 328 21 - - HYPH cord-273505-pcsw3vmx 328 22 dose dose NN cord-273505-pcsw3vmx 328 23 intravenous intravenous JJ cord-273505-pcsw3vmx 328 24 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 328 25 exerts exert VBZ cord-273505-pcsw3vmx 328 26 its -PRON- PRP$ cord-273505-pcsw3vmx 328 27 beneficial beneficial JJ cord-273505-pcsw3vmx 328 28 effect effect NN cord-273505-pcsw3vmx 328 29 in in IN cord-273505-pcsw3vmx 328 30 patients patient NNS cord-273505-pcsw3vmx 328 31 with with IN cord-273505-pcsw3vmx 328 32 dermatomyositis dermatomyositis NN cord-273505-pcsw3vmx 328 33 by by IN cord-273505-pcsw3vmx 328 34 blocking block VBG cord-273505-pcsw3vmx 328 35 endomysial endomysial JJ cord-273505-pcsw3vmx 328 36 deposition deposition NN cord-273505-pcsw3vmx 328 37 of of IN cord-273505-pcsw3vmx 328 38 activated activate VBN cord-273505-pcsw3vmx 328 39 complement complement NN cord-273505-pcsw3vmx 328 40 fragments fragment NNS cord-273505-pcsw3vmx 328 41 Intravenously intravenously RB cord-273505-pcsw3vmx 328 42 applied apply VBD cord-273505-pcsw3vmx 328 43 IgG igg NN cord-273505-pcsw3vmx 328 44 stimulates stimulate VBZ cord-273505-pcsw3vmx 328 45 complement complement JJ cord-273505-pcsw3vmx 328 46 attenuation attenuation NN cord-273505-pcsw3vmx 328 47 in in IN cord-273505-pcsw3vmx 328 48 a a DT cord-273505-pcsw3vmx 328 49 complement complement NN cord-273505-pcsw3vmx 328 50 - - HYPH cord-273505-pcsw3vmx 328 51 dependent dependent JJ cord-273505-pcsw3vmx 328 52 autoimmune autoimmune JJ cord-273505-pcsw3vmx 328 53 disease disease NN cord-273505-pcsw3vmx 328 54 at at IN cord-273505-pcsw3vmx 328 55 the the DT cord-273505-pcsw3vmx 328 56 amplifying amplify VBG cord-273505-pcsw3vmx 328 57 C3 c3 NN cord-273505-pcsw3vmx 328 58 convertase convertase NN cord-273505-pcsw3vmx 328 59 level level NN cord-273505-pcsw3vmx 328 60 Intravenous Intravenous NNP cord-273505-pcsw3vmx 328 61 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 328 62 ( ( -LRB- cord-273505-pcsw3vmx 328 63 IVIG IVIG NNP cord-273505-pcsw3vmx 328 64 ) ) -RRB- cord-273505-pcsw3vmx 328 65 protects protect VBZ cord-273505-pcsw3vmx 328 66 the the DT cord-273505-pcsw3vmx 328 67 brain brain NN cord-273505-pcsw3vmx 328 68 against against IN cord-273505-pcsw3vmx 328 69 experimental experimental JJ cord-273505-pcsw3vmx 328 70 stroke stroke NN cord-273505-pcsw3vmx 328 71 by by IN cord-273505-pcsw3vmx 328 72 preventing prevent VBG cord-273505-pcsw3vmx 328 73 complement complement NN cord-273505-pcsw3vmx 328 74 - - HYPH cord-273505-pcsw3vmx 328 75 mediated mediate VBN cord-273505-pcsw3vmx 328 76 neuronal neuronal JJ cord-273505-pcsw3vmx 328 77 cell cell NN cord-273505-pcsw3vmx 328 78 death death NN cord-273505-pcsw3vmx 328 79 Immunoglobulin Immunoglobulin NNP cord-273505-pcsw3vmx 328 80 in in IN cord-273505-pcsw3vmx 328 81 the the DT cord-273505-pcsw3vmx 328 82 control control NN cord-273505-pcsw3vmx 328 83 of of IN cord-273505-pcsw3vmx 328 84 complement complement JJ cord-273505-pcsw3vmx 328 85 action action NN cord-273505-pcsw3vmx 329 1 The the DT cord-273505-pcsw3vmx 329 2 binding binding NN cord-273505-pcsw3vmx 329 3 site site NN cord-273505-pcsw3vmx 329 4 for for IN cord-273505-pcsw3vmx 329 5 C1q C1q NNP cord-273505-pcsw3vmx 329 6 on on IN cord-273505-pcsw3vmx 329 7 IgG IgG NNP cord-273505-pcsw3vmx 329 8 Fc Fc NNP cord-273505-pcsw3vmx 329 9 - - HYPH cord-273505-pcsw3vmx 329 10 Galactosylation Galactosylation NNP cord-273505-pcsw3vmx 329 11 of of IN cord-273505-pcsw3vmx 329 12 human human JJ cord-273505-pcsw3vmx 329 13 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 329 14 gamma gamma NNP cord-273505-pcsw3vmx 329 15 isotypes isotypes NNP cord-273505-pcsw3vmx 329 16 improves improve VBZ cord-273505-pcsw3vmx 329 17 C1q C1q NNP cord-273505-pcsw3vmx 329 18 binding binding NN cord-273505-pcsw3vmx 329 19 and and CC cord-273505-pcsw3vmx 329 20 enhances enhance VBZ cord-273505-pcsw3vmx 329 21 complement complement NN cord-273505-pcsw3vmx 329 22 - - HYPH cord-273505-pcsw3vmx 329 23 dependent dependent JJ cord-273505-pcsw3vmx 329 24 cytotoxicity cytotoxicity NN cord-273505-pcsw3vmx 329 25 Endothelial endothelial JJ cord-273505-pcsw3vmx 329 26 cell cell NN cord-273505-pcsw3vmx 329 27 infection infection NN cord-273505-pcsw3vmx 329 28 and and CC cord-273505-pcsw3vmx 329 29 endotheliitis endotheliitis NN cord-273505-pcsw3vmx 329 30 in in IN cord-273505-pcsw3vmx 329 31 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 329 32 Complement Complement NNP cord-273505-pcsw3vmx 329 33 associated associate VBD cord-273505-pcsw3vmx 329 34 microvascular microvascular JJ cord-273505-pcsw3vmx 329 35 injury injury NN cord-273505-pcsw3vmx 329 36 and and CC cord-273505-pcsw3vmx 329 37 thrombosis thrombosis NN cord-273505-pcsw3vmx 329 38 in in IN cord-273505-pcsw3vmx 329 39 the the DT cord-273505-pcsw3vmx 329 40 pathogenesis pathogenesis NN cord-273505-pcsw3vmx 329 41 of of IN cord-273505-pcsw3vmx 329 42 severe severe JJ cord-273505-pcsw3vmx 329 43 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 329 44 infection infection NN cord-273505-pcsw3vmx 329 45 : : : cord-273505-pcsw3vmx 329 46 a a DT cord-273505-pcsw3vmx 329 47 report report NN cord-273505-pcsw3vmx 329 48 of of IN cord-273505-pcsw3vmx 329 49 five five CD cord-273505-pcsw3vmx 329 50 cases case NNS cord-273505-pcsw3vmx 330 1 The the DT cord-273505-pcsw3vmx 330 2 clinical clinical JJ cord-273505-pcsw3vmx 330 3 pathology pathology NN cord-273505-pcsw3vmx 330 4 of of IN cord-273505-pcsw3vmx 330 5 severe severe JJ cord-273505-pcsw3vmx 330 6 acute acute JJ cord-273505-pcsw3vmx 330 7 respiratory respiratory JJ cord-273505-pcsw3vmx 330 8 syndrome syndrome NN cord-273505-pcsw3vmx 330 9 ( ( -LRB- cord-273505-pcsw3vmx 330 10 SARS SARS NNP cord-273505-pcsw3vmx 330 11 ) ) -RRB- cord-273505-pcsw3vmx 330 12 : : : cord-273505-pcsw3vmx 330 13 a a DT cord-273505-pcsw3vmx 330 14 report report NN cord-273505-pcsw3vmx 330 15 from from IN cord-273505-pcsw3vmx 330 16 China China NNP cord-273505-pcsw3vmx 330 17 Exploring explore VBG cord-273505-pcsw3vmx 330 18 the the DT cord-273505-pcsw3vmx 330 19 pathogenesis pathogenesis NN cord-273505-pcsw3vmx 330 20 of of IN cord-273505-pcsw3vmx 330 21 severe severe JJ cord-273505-pcsw3vmx 330 22 acute acute JJ cord-273505-pcsw3vmx 330 23 respiratory respiratory JJ cord-273505-pcsw3vmx 330 24 syndrome syndrome NN cord-273505-pcsw3vmx 330 25 ( ( -LRB- cord-273505-pcsw3vmx 330 26 SARS SARS NNP cord-273505-pcsw3vmx 330 27 ) ) -RRB- cord-273505-pcsw3vmx 330 28 : : : cord-273505-pcsw3vmx 330 29 the the DT cord-273505-pcsw3vmx 330 30 tissue tissue NN cord-273505-pcsw3vmx 330 31 distribution distribution NN cord-273505-pcsw3vmx 330 32 of of IN cord-273505-pcsw3vmx 330 33 the the DT cord-273505-pcsw3vmx 330 34 coronavirus coronavirus NN cord-273505-pcsw3vmx 330 35 ( ( -LRB- cord-273505-pcsw3vmx 330 36 SARS SARS NNP cord-273505-pcsw3vmx 330 37 - - HYPH cord-273505-pcsw3vmx 330 38 CoV CoV NNP cord-273505-pcsw3vmx 330 39 ) ) -RRB- cord-273505-pcsw3vmx 330 40 and and CC cord-273505-pcsw3vmx 330 41 its -PRON- PRP$ cord-273505-pcsw3vmx 330 42 putative putative JJ cord-273505-pcsw3vmx 330 43 receptor receptor NN cord-273505-pcsw3vmx 330 44 , , , cord-273505-pcsw3vmx 330 45 angiotensin angiotensin NN cord-273505-pcsw3vmx 330 46 - - HYPH cord-273505-pcsw3vmx 330 47 converting convert VBG cord-273505-pcsw3vmx 330 48 enzyme enzyme NN cord-273505-pcsw3vmx 330 49 2 2 CD cord-273505-pcsw3vmx 331 1 ( ( -LRB- cord-273505-pcsw3vmx 331 2 ACE2 ACE2 NNP cord-273505-pcsw3vmx 331 3 ) ) -RRB- cord-273505-pcsw3vmx 331 4 Autoantibodies Autoantibodies NNP cord-273505-pcsw3vmx 331 5 against against IN cord-273505-pcsw3vmx 331 6 human human JJ cord-273505-pcsw3vmx 331 7 epithelial epithelial JJ cord-273505-pcsw3vmx 331 8 cells cell NNS cord-273505-pcsw3vmx 331 9 and and CC cord-273505-pcsw3vmx 331 10 endothelial endothelial JJ cord-273505-pcsw3vmx 331 11 cells cell NNS cord-273505-pcsw3vmx 331 12 after after IN cord-273505-pcsw3vmx 331 13 severe severe JJ cord-273505-pcsw3vmx 331 14 acute acute JJ cord-273505-pcsw3vmx 331 15 respiratory respiratory JJ cord-273505-pcsw3vmx 331 16 syndrome syndrome NN cord-273505-pcsw3vmx 331 17 ( ( -LRB- cord-273505-pcsw3vmx 331 18 SARS)-associated sars)-associated CD cord-273505-pcsw3vmx 331 19 coronavirus coronavirus NN cord-273505-pcsw3vmx 331 20 infection infection NN cord-273505-pcsw3vmx 331 21 Endothelial endothelial JJ cord-273505-pcsw3vmx 331 22 cells cell NNS cord-273505-pcsw3vmx 331 23 are be VBP cord-273505-pcsw3vmx 331 24 central central JJ cord-273505-pcsw3vmx 331 25 orchestrators orchestrator NNS cord-273505-pcsw3vmx 331 26 of of IN cord-273505-pcsw3vmx 331 27 cytokine cytokine NN cord-273505-pcsw3vmx 331 28 amplification amplification NN cord-273505-pcsw3vmx 331 29 during during IN cord-273505-pcsw3vmx 331 30 influenza influenza NN cord-273505-pcsw3vmx 331 31 virus virus NN cord-273505-pcsw3vmx 331 32 infection infection NN cord-273505-pcsw3vmx 331 33 Influenza Influenza NNP cord-273505-pcsw3vmx 331 34 viruscytokine viruscytokine NN cord-273505-pcsw3vmx 331 35 - - HYPH cord-273505-pcsw3vmx 331 36 protease protease NN cord-273505-pcsw3vmx 331 37 cycle cycle NN cord-273505-pcsw3vmx 331 38 in in IN cord-273505-pcsw3vmx 331 39 the the DT cord-273505-pcsw3vmx 331 40 pathogenesis pathogenesis NN cord-273505-pcsw3vmx 331 41 of of IN cord-273505-pcsw3vmx 331 42 vascular vascular JJ cord-273505-pcsw3vmx 331 43 hyperpermeability hyperpermeability NN cord-273505-pcsw3vmx 331 44 in in IN cord-273505-pcsw3vmx 331 45 severe severe JJ cord-273505-pcsw3vmx 331 46 influenza influenza NN cord-273505-pcsw3vmx 331 47 Influenza Influenza NNP cord-273505-pcsw3vmx 331 48 virus virus NN cord-273505-pcsw3vmx 331 49 and and CC cord-273505-pcsw3vmx 331 50 endothelial endothelial JJ cord-273505-pcsw3vmx 331 51 cells cell NNS cord-273505-pcsw3vmx 331 52 : : : cord-273505-pcsw3vmx 331 53 a a DT cord-273505-pcsw3vmx 331 54 species species NN cord-273505-pcsw3vmx 331 55 specific specific JJ cord-273505-pcsw3vmx 331 56 relationship relationship NN cord-273505-pcsw3vmx 331 57 Anti anti JJ cord-273505-pcsw3vmx 331 58 - - JJ cord-273505-pcsw3vmx 331 59 inflammatory inflammatory JJ cord-273505-pcsw3vmx 331 60 effects effect NNS cord-273505-pcsw3vmx 331 61 of of IN cord-273505-pcsw3vmx 331 62 high high JJ cord-273505-pcsw3vmx 331 63 - - HYPH cord-273505-pcsw3vmx 331 64 dose dose NN cord-273505-pcsw3vmx 331 65 IgG igg NN cord-273505-pcsw3vmx 331 66 on on IN cord-273505-pcsw3vmx 331 67 TNF TNF NNP cord-273505-pcsw3vmx 331 68 - - HYPH cord-273505-pcsw3vmx 331 69 alpha alpha NN cord-273505-pcsw3vmx 331 70 - - HYPH cord-273505-pcsw3vmx 331 71 activated activate VBN cord-273505-pcsw3vmx 331 72 human human JJ cord-273505-pcsw3vmx 331 73 coronary coronary JJ cord-273505-pcsw3vmx 331 74 artery artery NN cord-273505-pcsw3vmx 331 75 endothelial endothelial JJ cord-273505-pcsw3vmx 331 76 cells cell NNS cord-273505-pcsw3vmx 332 1 Anti anti JJ cord-273505-pcsw3vmx 332 2 - - JJ cord-273505-pcsw3vmx 332 3 inflammatory inflammatory JJ cord-273505-pcsw3vmx 332 4 effect effect NN cord-273505-pcsw3vmx 332 5 of of IN cord-273505-pcsw3vmx 332 6 intravenous intravenous JJ cord-273505-pcsw3vmx 332 7 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 332 8 in in IN cord-273505-pcsw3vmx 332 9 comparison comparison NN cord-273505-pcsw3vmx 332 10 with with IN cord-273505-pcsw3vmx 332 11 dexamethasone dexamethasone NN cord-273505-pcsw3vmx 332 12 in in IN cord-273505-pcsw3vmx 332 13 vitro vitro FW cord-273505-pcsw3vmx 332 14 : : : cord-273505-pcsw3vmx 332 15 implication implication NN cord-273505-pcsw3vmx 332 16 for for IN cord-273505-pcsw3vmx 332 17 treatment treatment NN cord-273505-pcsw3vmx 332 18 of of IN cord-273505-pcsw3vmx 332 19 Kawasaki Kawasaki NNP cord-273505-pcsw3vmx 332 20 disease disease NN cord-273505-pcsw3vmx 332 21 Effect Effect NNP cord-273505-pcsw3vmx 332 22 of of IN cord-273505-pcsw3vmx 332 23 maternal maternal JJ cord-273505-pcsw3vmx 332 24 anti anti NNP cord-273505-pcsw3vmx 332 25 - - NNP cord-273505-pcsw3vmx 332 26 HPA-1a HPA-1a NNP cord-273505-pcsw3vmx 332 27 antibodies antibody NNS cord-273505-pcsw3vmx 332 28 and and CC cord-273505-pcsw3vmx 332 29 polyclonal polyclonal JJ cord-273505-pcsw3vmx 332 30 IVIG ivig NN cord-273505-pcsw3vmx 332 31 on on IN cord-273505-pcsw3vmx 332 32 the the DT cord-273505-pcsw3vmx 332 33 activation activation NN cord-273505-pcsw3vmx 332 34 status status NN cord-273505-pcsw3vmx 332 35 of of IN cord-273505-pcsw3vmx 332 36 vascular vascular JJ cord-273505-pcsw3vmx 332 37 endothelial endothelial JJ cord-273505-pcsw3vmx 332 38 cells cell NNS cord-273505-pcsw3vmx 333 1 IRF-7 IRF-7 NNP cord-273505-pcsw3vmx 333 2 is be VBZ cord-273505-pcsw3vmx 333 3 the the DT cord-273505-pcsw3vmx 333 4 master master NN cord-273505-pcsw3vmx 333 5 regulator regulator NN cord-273505-pcsw3vmx 333 6 of of IN cord-273505-pcsw3vmx 333 7 type- type- NNP cord-273505-pcsw3vmx 334 1 I -PRON- PRP cord-273505-pcsw3vmx 334 2 interferon interferon NN cord-273505-pcsw3vmx 334 3 - - HYPH cord-273505-pcsw3vmx 334 4 dependent dependent JJ cord-273505-pcsw3vmx 334 5 immune immune JJ cord-273505-pcsw3vmx 334 6 responses response NNS cord-273505-pcsw3vmx 335 1 Spatiotemporal spatiotemporal JJ cord-273505-pcsw3vmx 335 2 regulation regulation NN cord-273505-pcsw3vmx 335 3 of of IN cord-273505-pcsw3vmx 335 4 MyD88-IRF-7 MyD88-IRF-7 NNS cord-273505-pcsw3vmx 335 5 signalling signal VBG cord-273505-pcsw3vmx 335 6 for for IN cord-273505-pcsw3vmx 335 7 robust robust JJ cord-273505-pcsw3vmx 335 8 type type NN cord-273505-pcsw3vmx 335 9 - - : cord-273505-pcsw3vmx 335 10 I i NN cord-273505-pcsw3vmx 336 1 interferon interferon NNP cord-273505-pcsw3vmx 336 2 induction induction NN cord-273505-pcsw3vmx 336 3 Imbalanced imbalanced JJ cord-273505-pcsw3vmx 336 4 host host NN cord-273505-pcsw3vmx 336 5 response response NN cord-273505-pcsw3vmx 336 6 to to IN cord-273505-pcsw3vmx 336 7 SARS SARS NNP cord-273505-pcsw3vmx 336 8 - - HYPH cord-273505-pcsw3vmx 336 9 CoV-2 CoV-2 NNP cord-273505-pcsw3vmx 336 10 drives drive VBZ cord-273505-pcsw3vmx 336 11 development development NN cord-273505-pcsw3vmx 336 12 of of IN cord-273505-pcsw3vmx 336 13 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 336 14 Severe severe JJ cord-273505-pcsw3vmx 336 15 acute acute JJ cord-273505-pcsw3vmx 336 16 respiratory respiratory JJ cord-273505-pcsw3vmx 336 17 syndrome syndrome NN cord-273505-pcsw3vmx 336 18 coronavirus coronavirus NN cord-273505-pcsw3vmx 336 19 ORF6 ORF6 NNP cord-273505-pcsw3vmx 337 1 antagonizes antagonize VBZ cord-273505-pcsw3vmx 337 2 STAT1 stat1 NN cord-273505-pcsw3vmx 337 3 function function NN cord-273505-pcsw3vmx 337 4 by by IN cord-273505-pcsw3vmx 337 5 sequestering sequester VBG cord-273505-pcsw3vmx 337 6 nuclear nuclear JJ cord-273505-pcsw3vmx 337 7 import import NN cord-273505-pcsw3vmx 337 8 factors factor NNS cord-273505-pcsw3vmx 337 9 on on IN cord-273505-pcsw3vmx 337 10 the the DT cord-273505-pcsw3vmx 337 11 rough rough JJ cord-273505-pcsw3vmx 337 12 endoplasmic endoplasmic NN cord-273505-pcsw3vmx 337 13 reticulum/ reticulum/ NN cord-273505-pcsw3vmx 338 1 Golgi Golgi NNP cord-273505-pcsw3vmx 338 2 membrane membrane NN cord-273505-pcsw3vmx 338 3 Severe severe JJ cord-273505-pcsw3vmx 338 4 acute acute JJ cord-273505-pcsw3vmx 338 5 respiratory respiratory JJ cord-273505-pcsw3vmx 338 6 syndrome syndrome NN cord-273505-pcsw3vmx 338 7 coronavirus coronavirus NN cord-273505-pcsw3vmx 338 8 nsp1 nsp1 CD cord-273505-pcsw3vmx 338 9 suppresses suppress VBZ cord-273505-pcsw3vmx 338 10 host host NN cord-273505-pcsw3vmx 338 11 gene gene NN cord-273505-pcsw3vmx 338 12 expression expression NN cord-273505-pcsw3vmx 338 13 , , , cord-273505-pcsw3vmx 338 14 including include VBG cord-273505-pcsw3vmx 338 15 that that DT cord-273505-pcsw3vmx 338 16 of of IN cord-273505-pcsw3vmx 338 17 type type NN cord-273505-pcsw3vmx 339 1 I -PRON- PRP cord-273505-pcsw3vmx 339 2 interferon interferon RB cord-273505-pcsw3vmx 340 1 , , , cord-273505-pcsw3vmx 340 2 in in IN cord-273505-pcsw3vmx 340 3 infected infected JJ cord-273505-pcsw3vmx 340 4 cells cell NNS cord-273505-pcsw3vmx 340 5 Coronavirus Coronavirus NNP cord-273505-pcsw3vmx 341 1 papain papain NN cord-273505-pcsw3vmx 341 2 - - HYPH cord-273505-pcsw3vmx 341 3 like like JJ cord-273505-pcsw3vmx 341 4 proteases protease NNS cord-273505-pcsw3vmx 341 5 negatively negatively RB cord-273505-pcsw3vmx 341 6 regulate regulate VBP cord-273505-pcsw3vmx 341 7 antiviral antiviral JJ cord-273505-pcsw3vmx 341 8 innate innate JJ cord-273505-pcsw3vmx 341 9 immune immune JJ cord-273505-pcsw3vmx 341 10 response response NN cord-273505-pcsw3vmx 341 11 through through IN cord-273505-pcsw3vmx 341 12 disruption disruption NN cord-273505-pcsw3vmx 341 13 of of IN cord-273505-pcsw3vmx 341 14 STING sting NN cord-273505-pcsw3vmx 341 15 - - HYPH cord-273505-pcsw3vmx 341 16 mediated mediate VBN cord-273505-pcsw3vmx 341 17 signaling signal VBG cord-273505-pcsw3vmx 341 18 Severe severe JJ cord-273505-pcsw3vmx 341 19 acute acute JJ cord-273505-pcsw3vmx 341 20 respiratory respiratory JJ cord-273505-pcsw3vmx 341 21 syndrome syndrome NN cord-273505-pcsw3vmx 341 22 coronavirus coronavirus NN cord-273505-pcsw3vmx 341 23 open open JJ cord-273505-pcsw3vmx 341 24 reading reading NN cord-273505-pcsw3vmx 341 25 frame frame NN cord-273505-pcsw3vmx 341 26 ( ( -LRB- cord-273505-pcsw3vmx 341 27 ORF ORF NNP cord-273505-pcsw3vmx 341 28 ) ) -RRB- cord-273505-pcsw3vmx 341 29 3b 3b NNP cord-273505-pcsw3vmx 341 30 , , , cord-273505-pcsw3vmx 341 31 ORF ORF NNP cord-273505-pcsw3vmx 341 32 6 6 CD cord-273505-pcsw3vmx 341 33 , , , cord-273505-pcsw3vmx 341 34 and and CC cord-273505-pcsw3vmx 341 35 nucleocapsid nucleocapsid NN cord-273505-pcsw3vmx 341 36 proteins protein NNS cord-273505-pcsw3vmx 341 37 function function VBP cord-273505-pcsw3vmx 341 38 as as IN cord-273505-pcsw3vmx 341 39 interferon interferon NN cord-273505-pcsw3vmx 341 40 antagonists antagonist NNS cord-273505-pcsw3vmx 341 41 MERS MERS NNP cord-273505-pcsw3vmx 341 42 - - HYPH cord-273505-pcsw3vmx 341 43 CoV CoV NNP cord-273505-pcsw3vmx 341 44 accessory accessory NN cord-273505-pcsw3vmx 341 45 ORFs orfs NN cord-273505-pcsw3vmx 341 46 play play VBP cord-273505-pcsw3vmx 341 47 key key JJ cord-273505-pcsw3vmx 341 48 role role NN cord-273505-pcsw3vmx 341 49 for for IN cord-273505-pcsw3vmx 341 50 infection infection NN cord-273505-pcsw3vmx 341 51 and and CC cord-273505-pcsw3vmx 341 52 pathogenesis pathogenesis NN cord-273505-pcsw3vmx 341 53 High high JJ cord-273505-pcsw3vmx 341 54 secretion secretion NN cord-273505-pcsw3vmx 341 55 of of IN cord-273505-pcsw3vmx 341 56 interferons interferon NNS cord-273505-pcsw3vmx 341 57 by by IN cord-273505-pcsw3vmx 341 58 human human JJ cord-273505-pcsw3vmx 341 59 plasmacytoid plasmacytoid NN cord-273505-pcsw3vmx 341 60 dendritic dendritic JJ cord-273505-pcsw3vmx 341 61 cells cell NNS cord-273505-pcsw3vmx 341 62 upon upon IN cord-273505-pcsw3vmx 341 63 recognition recognition NN cord-273505-pcsw3vmx 341 64 of of IN cord-273505-pcsw3vmx 341 65 Middle Middle NNP cord-273505-pcsw3vmx 341 66 East East NNP cord-273505-pcsw3vmx 341 67 respiratory respiratory JJ cord-273505-pcsw3vmx 341 68 syndrome syndrome NN cord-273505-pcsw3vmx 341 69 coronavirus coronavirus NN cord-273505-pcsw3vmx 341 70 Control Control NNP cord-273505-pcsw3vmx 341 71 of of IN cord-273505-pcsw3vmx 341 72 coronavirus coronavirus NN cord-273505-pcsw3vmx 341 73 infection infection NN cord-273505-pcsw3vmx 341 74 through through IN cord-273505-pcsw3vmx 341 75 plasmacytoid plasmacytoid JJ cord-273505-pcsw3vmx 341 76 dendritic dendritic JJ cord-273505-pcsw3vmx 341 77 - - HYPH cord-273505-pcsw3vmx 341 78 cell cell NN cord-273505-pcsw3vmx 341 79 - - HYPH cord-273505-pcsw3vmx 341 80 derived derive VBN cord-273505-pcsw3vmx 341 81 type type NN cord-273505-pcsw3vmx 342 1 I -PRON- PRP cord-273505-pcsw3vmx 342 2 interferon interferon VBD cord-273505-pcsw3vmx 342 3 Dysregulated Dysregulated NNP cord-273505-pcsw3vmx 342 4 type type NN cord-273505-pcsw3vmx 343 1 I -PRON- PRP cord-273505-pcsw3vmx 343 2 interferon interferon VBD cord-273505-pcsw3vmx 343 3 and and CC cord-273505-pcsw3vmx 343 4 inflammatory inflammatory JJ cord-273505-pcsw3vmx 343 5 monocyte monocyte JJ cord-273505-pcsw3vmx 343 6 - - HYPH cord-273505-pcsw3vmx 343 7 macrophage macrophage NN cord-273505-pcsw3vmx 343 8 responses response NNS cord-273505-pcsw3vmx 343 9 cause cause VBP cord-273505-pcsw3vmx 343 10 lethal lethal JJ cord-273505-pcsw3vmx 343 11 pneumonia pneumonia NN cord-273505-pcsw3vmx 343 12 in in IN cord-273505-pcsw3vmx 343 13 SARS SARS NNP cord-273505-pcsw3vmx 343 14 - - HYPH cord-273505-pcsw3vmx 343 15 CoV CoV NNP cord-273505-pcsw3vmx 343 16 - - HYPH cord-273505-pcsw3vmx 343 17 infected infect VBN cord-273505-pcsw3vmx 343 18 mice mouse NNS cord-273505-pcsw3vmx 344 1 Dose dose NN cord-273505-pcsw3vmx 344 2 - - HYPH cord-273505-pcsw3vmx 344 3 related relate VBN cord-273505-pcsw3vmx 344 4 regulatory regulatory JJ cord-273505-pcsw3vmx 344 5 effect effect NN cord-273505-pcsw3vmx 344 6 of of IN cord-273505-pcsw3vmx 344 7 intravenous intravenous JJ cord-273505-pcsw3vmx 344 8 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 344 9 on on IN cord-273505-pcsw3vmx 344 10 dendritic dendritic JJ cord-273505-pcsw3vmx 344 11 cells cell NNS cord-273505-pcsw3vmx 344 12 - - HYPH cord-273505-pcsw3vmx 344 13 mediated mediate VBN cord-273505-pcsw3vmx 344 14 immune immune JJ cord-273505-pcsw3vmx 344 15 response response NN cord-273505-pcsw3vmx 344 16 Inhibition inhibition NN cord-273505-pcsw3vmx 344 17 of of IN cord-273505-pcsw3vmx 344 18 maturation maturation NN cord-273505-pcsw3vmx 344 19 and and CC cord-273505-pcsw3vmx 344 20 function function NN cord-273505-pcsw3vmx 344 21 of of IN cord-273505-pcsw3vmx 344 22 dendritic dendritic JJ cord-273505-pcsw3vmx 344 23 cells cell NNS cord-273505-pcsw3vmx 344 24 by by IN cord-273505-pcsw3vmx 344 25 intravenous intravenous JJ cord-273505-pcsw3vmx 344 26 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 344 27 Intravenous Intravenous NNP cord-273505-pcsw3vmx 344 28 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 344 29 treatment treatment NN cord-273505-pcsw3vmx 344 30 in in IN cord-273505-pcsw3vmx 344 31 humans human NNS cord-273505-pcsw3vmx 344 32 suppresses suppress VBZ cord-273505-pcsw3vmx 344 33 dendritic dendritic JJ cord-273505-pcsw3vmx 344 34 cell cell NN cord-273505-pcsw3vmx 344 35 function function NN cord-273505-pcsw3vmx 344 36 via via IN cord-273505-pcsw3vmx 344 37 stimulation stimulation NN cord-273505-pcsw3vmx 344 38 of of IN cord-273505-pcsw3vmx 344 39 IL-4 IL-4 NNP cord-273505-pcsw3vmx 344 40 and and CC cord-273505-pcsw3vmx 344 41 IL-13 IL-13 NNP cord-273505-pcsw3vmx 344 42 production production NN cord-273505-pcsw3vmx 344 43 Dendritic dendritic JJ cord-273505-pcsw3vmx 344 44 cell cell NN cord-273505-pcsw3vmx 344 45 immunoreceptor immunoreceptor NN cord-273505-pcsw3vmx 344 46 : : : cord-273505-pcsw3vmx 345 1 a a DT cord-273505-pcsw3vmx 345 2 novel novel JJ cord-273505-pcsw3vmx 345 3 receptor receptor NN cord-273505-pcsw3vmx 345 4 for for IN cord-273505-pcsw3vmx 345 5 intravenous intravenous JJ cord-273505-pcsw3vmx 345 6 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 345 7 mediates mediate VBZ cord-273505-pcsw3vmx 345 8 induction induction NN cord-273505-pcsw3vmx 345 9 of of IN cord-273505-pcsw3vmx 345 10 regulatory regulatory JJ cord-273505-pcsw3vmx 345 11 T t NN cord-273505-pcsw3vmx 345 12 cells cell NNS cord-273505-pcsw3vmx 345 13 Effect effect NN cord-273505-pcsw3vmx 345 14 of of IN cord-273505-pcsw3vmx 345 15 IVIg IVIg NNP cord-273505-pcsw3vmx 345 16 on on IN cord-273505-pcsw3vmx 345 17 human human JJ cord-273505-pcsw3vmx 345 18 dendritic dendritic JJ cord-273505-pcsw3vmx 345 19 cell cell NN cord-273505-pcsw3vmx 345 20 - - HYPH cord-273505-pcsw3vmx 345 21 mediated mediate VBN cord-273505-pcsw3vmx 345 22 antigen antigen NN cord-273505-pcsw3vmx 345 23 uptake uptake NN cord-273505-pcsw3vmx 345 24 and and CC cord-273505-pcsw3vmx 345 25 presentation presentation NN cord-273505-pcsw3vmx 345 26 : : : cord-273505-pcsw3vmx 345 27 role role NN cord-273505-pcsw3vmx 345 28 of of IN cord-273505-pcsw3vmx 345 29 lipid lipid NN cord-273505-pcsw3vmx 345 30 accumulation accumulation NN cord-273505-pcsw3vmx 345 31 Superior Superior NNP cord-273505-pcsw3vmx 345 32 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 345 33 effects effect NNS cord-273505-pcsw3vmx 345 34 of of IN cord-273505-pcsw3vmx 345 35 intravenous intravenous JJ cord-273505-pcsw3vmx 345 36 immunoglobulins immunoglobulin NNS cord-273505-pcsw3vmx 345 37 on on IN cord-273505-pcsw3vmx 345 38 human human JJ cord-273505-pcsw3vmx 345 39 T t NN cord-273505-pcsw3vmx 345 40 - - HYPH cord-273505-pcsw3vmx 345 41 cells cell NNS cord-273505-pcsw3vmx 345 42 and and CC cord-273505-pcsw3vmx 345 43 dendritic dendritic JJ cord-273505-pcsw3vmx 345 44 cells cell NNS cord-273505-pcsw3vmx 345 45 : : : cord-273505-pcsw3vmx 345 46 comparison comparison NN cord-273505-pcsw3vmx 345 47 to to IN cord-273505-pcsw3vmx 345 48 calcineurin calcineurin NN cord-273505-pcsw3vmx 345 49 inhibitors inhibitor NNS cord-273505-pcsw3vmx 345 50 Complex complex JJ cord-273505-pcsw3vmx 345 51 immune immune JJ cord-273505-pcsw3vmx 345 52 dysregulation dysregulation NN cord-273505-pcsw3vmx 345 53 in in IN cord-273505-pcsw3vmx 345 54 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 345 55 patients patient NNS cord-273505-pcsw3vmx 345 56 with with IN cord-273505-pcsw3vmx 345 57 severe severe JJ cord-273505-pcsw3vmx 345 58 respiratory respiratory JJ cord-273505-pcsw3vmx 345 59 failure failure NN cord-273505-pcsw3vmx 346 1 The the DT cord-273505-pcsw3vmx 346 2 novel novel JJ cord-273505-pcsw3vmx 346 3 severe severe JJ cord-273505-pcsw3vmx 346 4 acute acute JJ cord-273505-pcsw3vmx 346 5 respiratory respiratory JJ cord-273505-pcsw3vmx 346 6 syndrome syndrome NN cord-273505-pcsw3vmx 346 7 Coronavirus Coronavirus NNP cord-273505-pcsw3vmx 346 8 2 2 CD cord-273505-pcsw3vmx 347 1 ( ( -LRB- cord-273505-pcsw3vmx 347 2 SARS SARS NNP cord-273505-pcsw3vmx 347 3 - - HYPH cord-273505-pcsw3vmx 347 4 CoV-2 CoV-2 NNP cord-273505-pcsw3vmx 347 5 ) ) -RRB- cord-273505-pcsw3vmx 347 6 directly directly RB cord-273505-pcsw3vmx 347 7 decimates decimate VBZ cord-273505-pcsw3vmx 347 8 human human JJ cord-273505-pcsw3vmx 347 9 spleens spleen NNS cord-273505-pcsw3vmx 347 10 and and CC cord-273505-pcsw3vmx 347 11 lymph lymph NN cord-273505-pcsw3vmx 347 12 nodes node NNS cord-273505-pcsw3vmx 347 13 . . . cord-273505-pcsw3vmx 348 1 medRxiv medRxiv NNP cord-273505-pcsw3vmx 348 2 Antispike Antispike NNP cord-273505-pcsw3vmx 348 3 IgG igg NN cord-273505-pcsw3vmx 348 4 causes cause VBZ cord-273505-pcsw3vmx 348 5 severe severe JJ cord-273505-pcsw3vmx 348 6 acute acute JJ cord-273505-pcsw3vmx 348 7 lung lung NN cord-273505-pcsw3vmx 348 8 injury injury NN cord-273505-pcsw3vmx 348 9 by by IN cord-273505-pcsw3vmx 348 10 skewing skew VBG cord-273505-pcsw3vmx 348 11 macrophage macrophage NN cord-273505-pcsw3vmx 348 12 responses response NNS cord-273505-pcsw3vmx 348 13 during during IN cord-273505-pcsw3vmx 348 14 acute acute JJ cord-273505-pcsw3vmx 348 15 SARS SARS NNP cord-273505-pcsw3vmx 348 16 - - HYPH cord-273505-pcsw3vmx 348 17 CoV CoV NNP cord-273505-pcsw3vmx 348 18 infection infection NN cord-273505-pcsw3vmx 348 19 Cytokine cytokine NN cord-273505-pcsw3vmx 348 20 responses response NNS cord-273505-pcsw3vmx 348 21 in in IN cord-273505-pcsw3vmx 348 22 severe severe JJ cord-273505-pcsw3vmx 348 23 acute acute JJ cord-273505-pcsw3vmx 348 24 respiratory respiratory JJ cord-273505-pcsw3vmx 348 25 syndrome syndrome NN cord-273505-pcsw3vmx 348 26 coronavirus coronavirus NN cord-273505-pcsw3vmx 348 27 - - HYPH cord-273505-pcsw3vmx 348 28 infected infect VBN cord-273505-pcsw3vmx 348 29 macrophages macrophage NNS cord-273505-pcsw3vmx 348 30 in in IN cord-273505-pcsw3vmx 348 31 vitro vitro FW cord-273505-pcsw3vmx 348 32 : : : cord-273505-pcsw3vmx 348 33 possible possible JJ cord-273505-pcsw3vmx 348 34 relevance relevance NN cord-273505-pcsw3vmx 348 35 to to TO cord-273505-pcsw3vmx 348 36 pathogenesis pathogenesis VB cord-273505-pcsw3vmx 348 37 Up up RP cord-273505-pcsw3vmx 348 38 - - HYPH cord-273505-pcsw3vmx 348 39 regulation regulation NN cord-273505-pcsw3vmx 348 40 of of IN cord-273505-pcsw3vmx 348 41 IL-6 IL-6 NNP cord-273505-pcsw3vmx 348 42 and and CC cord-273505-pcsw3vmx 348 43 TNF TNF NNP cord-273505-pcsw3vmx 348 44 - - HYPH cord-273505-pcsw3vmx 348 45 alpha alpha NN cord-273505-pcsw3vmx 348 46 induced induce VBN cord-273505-pcsw3vmx 348 47 by by IN cord-273505-pcsw3vmx 348 48 SARS SARS NNP cord-273505-pcsw3vmx 348 49 - - HYPH cord-273505-pcsw3vmx 348 50 coronavirus coronavirus NN cord-273505-pcsw3vmx 348 51 spike spike NN cord-273505-pcsw3vmx 348 52 protein protein NN cord-273505-pcsw3vmx 348 53 in in IN cord-273505-pcsw3vmx 348 54 murine murine JJ cord-273505-pcsw3vmx 348 55 macrophages macrophage NNS cord-273505-pcsw3vmx 348 56 via via IN cord-273505-pcsw3vmx 349 1 NF NF NNP cord-273505-pcsw3vmx 349 2 - - HYPH cord-273505-pcsw3vmx 349 3 kappaB kappaB NNP cord-273505-pcsw3vmx 349 4 pathway pathway NN cord-273505-pcsw3vmx 349 5 SARS SARS NNP cord-273505-pcsw3vmx 349 6 coronavirus coronavirus NN cord-273505-pcsw3vmx 349 7 spike spike NN cord-273505-pcsw3vmx 349 8 protein protein NN cord-273505-pcsw3vmx 349 9 - - HYPH cord-273505-pcsw3vmx 349 10 induced induce VBN cord-273505-pcsw3vmx 349 11 innate innate JJ cord-273505-pcsw3vmx 349 12 immune immune JJ cord-273505-pcsw3vmx 349 13 response response NN cord-273505-pcsw3vmx 349 14 occurs occur VBZ cord-273505-pcsw3vmx 349 15 via via IN cord-273505-pcsw3vmx 349 16 activation activation NN cord-273505-pcsw3vmx 349 17 of of IN cord-273505-pcsw3vmx 349 18 the the DT cord-273505-pcsw3vmx 349 19 NF NF NNP cord-273505-pcsw3vmx 349 20 - - HYPH cord-273505-pcsw3vmx 349 21 kappaB kappaB NNP cord-273505-pcsw3vmx 349 22 pathway pathway NN cord-273505-pcsw3vmx 349 23 in in IN cord-273505-pcsw3vmx 349 24 human human JJ cord-273505-pcsw3vmx 349 25 monocyte monocyte NNP cord-273505-pcsw3vmx 349 26 macrophages macrophage NNS cord-273505-pcsw3vmx 349 27 in in IN cord-273505-pcsw3vmx 349 28 vitro vitro FW cord-273505-pcsw3vmx 349 29 Monocyte Monocyte NNP cord-273505-pcsw3vmx 349 30 - - HYPH cord-273505-pcsw3vmx 349 31 macrophage macrophage NN cord-273505-pcsw3vmx 349 32 system system NN cord-273505-pcsw3vmx 349 33 as as IN cord-273505-pcsw3vmx 349 34 targets target NNS cord-273505-pcsw3vmx 349 35 for for IN cord-273505-pcsw3vmx 349 36 immunomodulation immunomodulation NN cord-273505-pcsw3vmx 349 37 by by IN cord-273505-pcsw3vmx 349 38 intravenous intravenous JJ cord-273505-pcsw3vmx 349 39 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 349 40 Macrophage Macrophage NNP cord-273505-pcsw3vmx 349 41 activation activation NN cord-273505-pcsw3vmx 349 42 syndrome syndrome NN cord-273505-pcsw3vmx 349 43 in in IN cord-273505-pcsw3vmx 349 44 systemic systemic JJ cord-273505-pcsw3vmx 349 45 lupus lupus NN cord-273505-pcsw3vmx 349 46 erythematosus erythematosus NN cord-273505-pcsw3vmx 349 47 : : : cord-273505-pcsw3vmx 349 48 a a DT cord-273505-pcsw3vmx 349 49 multicenter multicenter NN cord-273505-pcsw3vmx 349 50 , , , cord-273505-pcsw3vmx 349 51 case case NN cord-273505-pcsw3vmx 349 52 - - HYPH cord-273505-pcsw3vmx 349 53 control control NN cord-273505-pcsw3vmx 349 54 study study NN cord-273505-pcsw3vmx 349 55 in in IN cord-273505-pcsw3vmx 349 56 China China NNP cord-273505-pcsw3vmx 349 57 Clinical clinical JJ cord-273505-pcsw3vmx 349 58 characteristics characteristic NNS cord-273505-pcsw3vmx 349 59 and and CC cord-273505-pcsw3vmx 349 60 treatment treatment NN cord-273505-pcsw3vmx 349 61 outcomes outcome NNS cord-273505-pcsw3vmx 349 62 of of IN cord-273505-pcsw3vmx 349 63 macrophage macrophage NN cord-273505-pcsw3vmx 349 64 activation activation NN cord-273505-pcsw3vmx 349 65 syndrome syndrome NN cord-273505-pcsw3vmx 349 66 in in IN cord-273505-pcsw3vmx 349 67 adults adult NNS cord-273505-pcsw3vmx 349 68 : : : cord-273505-pcsw3vmx 349 69 a a DT cord-273505-pcsw3vmx 349 70 case case NN cord-273505-pcsw3vmx 349 71 series series NN cord-273505-pcsw3vmx 349 72 of of IN cord-273505-pcsw3vmx 349 73 67 67 CD cord-273505-pcsw3vmx 349 74 patients patient NNS cord-273505-pcsw3vmx 349 75 Beijing Beijing NNP cord-273505-pcsw3vmx 349 76 Da Da NNP cord-273505-pcsw3vmx 349 77 Xue Xue NNP cord-273505-pcsw3vmx 349 78 Xue Xue NNP cord-273505-pcsw3vmx 349 79 Bao Bao NNP cord-273505-pcsw3vmx 349 80 Yi Yi NNP cord-273505-pcsw3vmx 349 81 Xue Xue NNP cord-273505-pcsw3vmx 350 1 Ban Ban NNP cord-273505-pcsw3vmx 350 2 Kawasaki Kawasaki NNP cord-273505-pcsw3vmx 350 3 disease disease NN cord-273505-pcsw3vmx 350 4 complicated complicate VBN cord-273505-pcsw3vmx 350 5 with with IN cord-273505-pcsw3vmx 350 6 macrophage macrophage NN cord-273505-pcsw3vmx 350 7 activation activation NN cord-273505-pcsw3vmx 350 8 syndrome syndrome NN cord-273505-pcsw3vmx 350 9 : : : cord-273505-pcsw3vmx 350 10 case case NN cord-273505-pcsw3vmx 350 11 reports report NNS cord-273505-pcsw3vmx 350 12 and and CC cord-273505-pcsw3vmx 350 13 literature literature NN cord-273505-pcsw3vmx 350 14 review review NN cord-273505-pcsw3vmx 350 15 Macrophage Macrophage NNP cord-273505-pcsw3vmx 350 16 activation activation NN cord-273505-pcsw3vmx 350 17 syndrome syndrome NN cord-273505-pcsw3vmx 350 18 IVIg ivig VBP cord-273505-pcsw3vmx 350 19 promote promote VBP cord-273505-pcsw3vmx 350 20 cross cross NN cord-273505-pcsw3vmx 350 21 - - NN cord-273505-pcsw3vmx 350 22 tolerance tolerance NN cord-273505-pcsw3vmx 350 23 against against IN cord-273505-pcsw3vmx 350 24 inflammatory inflammatory JJ cord-273505-pcsw3vmx 350 25 stimuli stimulus NNS cord-273505-pcsw3vmx 350 26 in in IN cord-273505-pcsw3vmx 350 27 vitro vitro FW cord-273505-pcsw3vmx 350 28 and and CC cord-273505-pcsw3vmx 350 29 in in IN cord-273505-pcsw3vmx 350 30 vivo vivo NN cord-273505-pcsw3vmx 351 1 Intravenous intravenous JJ cord-273505-pcsw3vmx 351 2 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 351 3 promotes promote VBZ cord-273505-pcsw3vmx 351 4 antitumor antitumor JJ cord-273505-pcsw3vmx 351 5 responses response NNS cord-273505-pcsw3vmx 351 6 by by IN cord-273505-pcsw3vmx 351 7 modulating modulate VBG cord-273505-pcsw3vmx 351 8 macrophage macrophage NN cord-273505-pcsw3vmx 351 9 polarization polarization NN cord-273505-pcsw3vmx 351 10 IVIg ivig NN cord-273505-pcsw3vmx 351 11 and and CC cord-273505-pcsw3vmx 351 12 LPS LPS NNP cord-273505-pcsw3vmx 351 13 co co NN cord-273505-pcsw3vmx 351 14 - - NN cord-273505-pcsw3vmx 351 15 stimulation stimulation NN cord-273505-pcsw3vmx 351 16 induces induce VBZ cord-273505-pcsw3vmx 352 1 IL-10 IL-10 NNP cord-273505-pcsw3vmx 352 2 production production NN cord-273505-pcsw3vmx 352 3 by by IN cord-273505-pcsw3vmx 352 4 human human JJ cord-273505-pcsw3vmx 352 5 monocytes monocyte NNS cord-273505-pcsw3vmx 352 6 , , , cord-273505-pcsw3vmx 352 7 which which WDT cord-273505-pcsw3vmx 352 8 is be VBZ cord-273505-pcsw3vmx 352 9 compromised compromise VBN cord-273505-pcsw3vmx 352 10 by by IN cord-273505-pcsw3vmx 352 11 an an DT cord-273505-pcsw3vmx 352 12 FcgammaRIIA FcgammaRIIA NNP cord-273505-pcsw3vmx 352 13 disease disease NN cord-273505-pcsw3vmx 352 14 - - HYPH cord-273505-pcsw3vmx 352 15 associated associate VBN cord-273505-pcsw3vmx 352 16 gene gene NN cord-273505-pcsw3vmx 352 17 variant variant NN cord-273505-pcsw3vmx 352 18 Excessive excessive JJ cord-273505-pcsw3vmx 352 19 neutrophils neutrophil NNS cord-273505-pcsw3vmx 352 20 and and CC cord-273505-pcsw3vmx 352 21 neutrophil neutrophil NN cord-273505-pcsw3vmx 352 22 extracellular extracellular JJ cord-273505-pcsw3vmx 352 23 traps trap NNS cord-273505-pcsw3vmx 352 24 contribute contribute VBP cord-273505-pcsw3vmx 352 25 to to IN cord-273505-pcsw3vmx 352 26 acute acute JJ cord-273505-pcsw3vmx 352 27 lung lung NN cord-273505-pcsw3vmx 352 28 injury injury NN cord-273505-pcsw3vmx 352 29 of of IN cord-273505-pcsw3vmx 352 30 influenza influenza NN cord-273505-pcsw3vmx 352 31 pneumonitis pneumonitis NN cord-273505-pcsw3vmx 352 32 High high JJ cord-273505-pcsw3vmx 352 33 level level NN cord-273505-pcsw3vmx 352 34 of of IN cord-273505-pcsw3vmx 352 35 neutrophil neutrophil NN cord-273505-pcsw3vmx 352 36 extracellular extracellular JJ cord-273505-pcsw3vmx 352 37 traps trap NNS cord-273505-pcsw3vmx 352 38 correlates correlate VBZ cord-273505-pcsw3vmx 352 39 with with IN cord-273505-pcsw3vmx 352 40 poor poor JJ cord-273505-pcsw3vmx 352 41 prognosis prognosis NN cord-273505-pcsw3vmx 352 42 of of IN cord-273505-pcsw3vmx 352 43 severe severe JJ cord-273505-pcsw3vmx 352 44 influenza influenza NN cord-273505-pcsw3vmx 352 45 a a DT cord-273505-pcsw3vmx 352 46 infection infection NN cord-273505-pcsw3vmx 352 47 Targeting target VBG cord-273505-pcsw3vmx 352 48 potential potential JJ cord-273505-pcsw3vmx 352 49 drivers driver NNS cord-273505-pcsw3vmx 352 50 of of IN cord-273505-pcsw3vmx 352 51 COVID-19 covid-19 NN cord-273505-pcsw3vmx 352 52 : : : cord-273505-pcsw3vmx 352 53 neutrophil neutrophil NN cord-273505-pcsw3vmx 352 54 extracellular extracellular JJ cord-273505-pcsw3vmx 352 55 traps trap NNS cord-273505-pcsw3vmx 353 1 Neutrophil Neutrophil NNP cord-273505-pcsw3vmx 353 2 extracellular extracellular JJ cord-273505-pcsw3vmx 353 3 traps trap NNS cord-273505-pcsw3vmx 353 4 in in IN cord-273505-pcsw3vmx 353 5 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 353 6 Decreased decrease VBN cord-273505-pcsw3vmx 353 7 nitric nitric JJ cord-273505-pcsw3vmx 353 8 oxide oxide NN cord-273505-pcsw3vmx 353 9 production production NN cord-273505-pcsw3vmx 353 10 after after IN cord-273505-pcsw3vmx 353 11 intravenous intravenous JJ cord-273505-pcsw3vmx 353 12 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 353 13 treatment treatment NN cord-273505-pcsw3vmx 353 14 in in IN cord-273505-pcsw3vmx 353 15 patients patient NNS cord-273505-pcsw3vmx 353 16 with with IN cord-273505-pcsw3vmx 353 17 Kawasaki Kawasaki NNP cord-273505-pcsw3vmx 353 18 disease disease NN cord-273505-pcsw3vmx 353 19 Intravenous intravenous JJ cord-273505-pcsw3vmx 353 20 immunoglobulins immunoglobulin NNS cord-273505-pcsw3vmx 353 21 modulate modulate VBP cord-273505-pcsw3vmx 353 22 neutrophil neutrophil NN cord-273505-pcsw3vmx 353 23 activation activation NN cord-273505-pcsw3vmx 353 24 and and CC cord-273505-pcsw3vmx 353 25 vascular vascular JJ cord-273505-pcsw3vmx 353 26 injury injury NN cord-273505-pcsw3vmx 353 27 through through IN cord-273505-pcsw3vmx 353 28 FcγRIII fcγriii NN cord-273505-pcsw3vmx 353 29 and and CC cord-273505-pcsw3vmx 353 30 SHP-1 SHP-1 NNP cord-273505-pcsw3vmx 353 31 IVIG IVIG NNP cord-273505-pcsw3vmx 353 32 regulates regulate VBZ cord-273505-pcsw3vmx 353 33 the the DT cord-273505-pcsw3vmx 353 34 survival survival NN cord-273505-pcsw3vmx 353 35 of of IN cord-273505-pcsw3vmx 353 36 human human NN cord-273505-pcsw3vmx 353 37 but but CC cord-273505-pcsw3vmx 353 38 not not RB cord-273505-pcsw3vmx 353 39 mouse mouse NN cord-273505-pcsw3vmx 353 40 neutrophils neutrophil NNS cord-273505-pcsw3vmx 353 41 . . . cord-273505-pcsw3vmx 354 1 Sci Sci NNP cord-273505-pcsw3vmx 354 2 Rep Rep NNP cord-273505-pcsw3vmx 354 3 Granulocyte Granulocyte NNP cord-273505-pcsw3vmx 354 4 death death NN cord-273505-pcsw3vmx 354 5 mediated mediate VBN cord-273505-pcsw3vmx 354 6 by by IN cord-273505-pcsw3vmx 354 7 specific specific JJ cord-273505-pcsw3vmx 354 8 antibodies antibody NNS cord-273505-pcsw3vmx 354 9 in in IN cord-273505-pcsw3vmx 354 10 intravenous intravenous JJ cord-273505-pcsw3vmx 354 11 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 354 12 ( ( -LRB- cord-273505-pcsw3vmx 354 13 IVIG IVIG NNP cord-273505-pcsw3vmx 354 14 ) ) -RRB- cord-273505-pcsw3vmx 355 1 Pharmaceutical pharmaceutical JJ cord-273505-pcsw3vmx 355 2 immunoglobulins immunoglobulin NNS cord-273505-pcsw3vmx 355 3 reduce reduce VBP cord-273505-pcsw3vmx 355 4 neutrophil neutrophil NN cord-273505-pcsw3vmx 355 5 extracellular extracellular JJ cord-273505-pcsw3vmx 355 6 trap trap NN cord-273505-pcsw3vmx 355 7 formation formation NN cord-273505-pcsw3vmx 355 8 and and CC cord-273505-pcsw3vmx 355 9 ameliorate ameliorate VB cord-273505-pcsw3vmx 355 10 the the DT cord-273505-pcsw3vmx 355 11 development development NN cord-273505-pcsw3vmx 355 12 of of IN cord-273505-pcsw3vmx 355 13 MPO MPO NNP cord-273505-pcsw3vmx 355 14 - - HYPH cord-273505-pcsw3vmx 355 15 ANCA ANCA NNP cord-273505-pcsw3vmx 355 16 - - HYPH cord-273505-pcsw3vmx 355 17 associated associate VBN cord-273505-pcsw3vmx 355 18 vasculitis vasculitis NN cord-273505-pcsw3vmx 355 19 Functional functional JJ cord-273505-pcsw3vmx 355 20 exhaustion exhaustion NN cord-273505-pcsw3vmx 355 21 of of IN cord-273505-pcsw3vmx 355 22 antiviral antiviral JJ cord-273505-pcsw3vmx 355 23 lymphocytes lymphocyte NNS cord-273505-pcsw3vmx 355 24 in in IN cord-273505-pcsw3vmx 355 25 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 355 26 patients patient NNS cord-273505-pcsw3vmx 355 27 National National NNP cord-273505-pcsw3vmx 355 28 Research Research NNP cord-273505-pcsw3vmx 355 29 Project Project NNP cord-273505-pcsw3vmx 355 30 for for IN cord-273505-pcsw3vmx 355 31 SARS SARS NNP cord-273505-pcsw3vmx 355 32 BG BG NNP cord-273505-pcsw3vmx 355 33 . . . cord-273505-pcsw3vmx 356 1 The the DT cord-273505-pcsw3vmx 356 2 involvement involvement NN cord-273505-pcsw3vmx 356 3 of of IN cord-273505-pcsw3vmx 356 4 natural natural JJ cord-273505-pcsw3vmx 356 5 killer killer NN cord-273505-pcsw3vmx 356 6 cells cell NNS cord-273505-pcsw3vmx 356 7 in in IN cord-273505-pcsw3vmx 356 8 the the DT cord-273505-pcsw3vmx 356 9 pathogenesis pathogenesis NN cord-273505-pcsw3vmx 356 10 of of IN cord-273505-pcsw3vmx 356 11 severe severe JJ cord-273505-pcsw3vmx 356 12 acute acute JJ cord-273505-pcsw3vmx 356 13 respiratory respiratory JJ cord-273505-pcsw3vmx 356 14 syndrome syndrome NN cord-273505-pcsw3vmx 356 15 Viral viral JJ cord-273505-pcsw3vmx 356 16 infection infection NN cord-273505-pcsw3vmx 356 17 of of IN cord-273505-pcsw3vmx 356 18 human human JJ cord-273505-pcsw3vmx 356 19 natural natural JJ cord-273505-pcsw3vmx 356 20 killer killer NN cord-273505-pcsw3vmx 356 21 cells cell NNS cord-273505-pcsw3vmx 356 22 Influenza Influenza NNP cord-273505-pcsw3vmx 356 23 virus virus NN cord-273505-pcsw3vmx 356 24 directly directly RB cord-273505-pcsw3vmx 356 25 infects infect VBZ cord-273505-pcsw3vmx 356 26 human human JJ cord-273505-pcsw3vmx 356 27 natural natural JJ cord-273505-pcsw3vmx 356 28 killer killer NN cord-273505-pcsw3vmx 356 29 cells cell NNS cord-273505-pcsw3vmx 356 30 and and CC cord-273505-pcsw3vmx 356 31 induces induce VBZ cord-273505-pcsw3vmx 357 1 cell cell NN cord-273505-pcsw3vmx 357 2 apoptosis apoptosis NN cord-273505-pcsw3vmx 358 1 The the DT cord-273505-pcsw3vmx 358 2 effect effect NN cord-273505-pcsw3vmx 358 3 of of IN cord-273505-pcsw3vmx 358 4 IgG igg NN cord-273505-pcsw3vmx 358 5 levels level NNS cord-273505-pcsw3vmx 358 6 on on IN cord-273505-pcsw3vmx 358 7 the the DT cord-273505-pcsw3vmx 358 8 number number NN cord-273505-pcsw3vmx 358 9 of of IN cord-273505-pcsw3vmx 358 10 natural natural JJ cord-273505-pcsw3vmx 358 11 killer killer NN cord-273505-pcsw3vmx 358 12 cells cell NNS cord-273505-pcsw3vmx 358 13 and and CC cord-273505-pcsw3vmx 358 14 their -PRON- PRP$ cord-273505-pcsw3vmx 358 15 Fc Fc NNP cord-273505-pcsw3vmx 358 16 receptors receptor NNS cord-273505-pcsw3vmx 358 17 in in IN cord-273505-pcsw3vmx 358 18 chronic chronic JJ cord-273505-pcsw3vmx 358 19 inflammatory inflammatory JJ cord-273505-pcsw3vmx 358 20 demyelinating demyelinating NN cord-273505-pcsw3vmx 358 21 polyradiculoneuropathy polyradiculoneuropathy NNP cord-273505-pcsw3vmx 358 22 NK NK NNP cord-273505-pcsw3vmx 358 23 cell cell NN cord-273505-pcsw3vmx 358 24 compartment compartment NN cord-273505-pcsw3vmx 358 25 in in IN cord-273505-pcsw3vmx 358 26 the the DT cord-273505-pcsw3vmx 358 27 peripheral peripheral JJ cord-273505-pcsw3vmx 358 28 blood blood NN cord-273505-pcsw3vmx 358 29 and and CC cord-273505-pcsw3vmx 358 30 spleen spleen NNS cord-273505-pcsw3vmx 358 31 in in IN cord-273505-pcsw3vmx 358 32 adult adult NN cord-273505-pcsw3vmx 358 33 patients patient NNS cord-273505-pcsw3vmx 358 34 with with IN cord-273505-pcsw3vmx 358 35 primary primary JJ cord-273505-pcsw3vmx 358 36 immune immune JJ cord-273505-pcsw3vmx 358 37 thrombocytopenia thrombocytopenia NN cord-273505-pcsw3vmx 358 38 NK NK NNP cord-273505-pcsw3vmx 358 39 cell cell NN cord-273505-pcsw3vmx 358 40 frequency frequency NN cord-273505-pcsw3vmx 358 41 and and CC cord-273505-pcsw3vmx 358 42 cytotoxicity cytotoxicity NN cord-273505-pcsw3vmx 358 43 in in IN cord-273505-pcsw3vmx 358 44 correlation correlation NN cord-273505-pcsw3vmx 358 45 to to IN cord-273505-pcsw3vmx 358 46 pregnancy pregnancy NN cord-273505-pcsw3vmx 358 47 outcome outcome NN cord-273505-pcsw3vmx 358 48 and and CC cord-273505-pcsw3vmx 358 49 response response NN cord-273505-pcsw3vmx 358 50 to to IN cord-273505-pcsw3vmx 358 51 IVIG IVIG NNP cord-273505-pcsw3vmx 358 52 therapy therapy NN cord-273505-pcsw3vmx 358 53 among among IN cord-273505-pcsw3vmx 358 54 women woman NNS cord-273505-pcsw3vmx 358 55 with with IN cord-273505-pcsw3vmx 358 56 recurrent recurrent JJ cord-273505-pcsw3vmx 358 57 pregnancy pregnancy NN cord-273505-pcsw3vmx 358 58 loss loss NN cord-273505-pcsw3vmx 358 59 Effect effect NN cord-273505-pcsw3vmx 358 60 of of IN cord-273505-pcsw3vmx 358 61 intravenous intravenous JJ cord-273505-pcsw3vmx 358 62 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 358 63 G g NN cord-273505-pcsw3vmx 358 64 therapy therapy NN cord-273505-pcsw3vmx 358 65 on on IN cord-273505-pcsw3vmx 358 66 natural natural JJ cord-273505-pcsw3vmx 358 67 killer killer NN cord-273505-pcsw3vmx 358 68 cell cell NN cord-273505-pcsw3vmx 358 69 function function NN cord-273505-pcsw3vmx 358 70 related relate VBN cord-273505-pcsw3vmx 358 71 to to IN cord-273505-pcsw3vmx 358 72 Fc Fc NNP cord-273505-pcsw3vmx 358 73 gamma gamma NN cord-273505-pcsw3vmx 358 74 receptor receptor NN cord-273505-pcsw3vmx 358 75 gene gene NN cord-273505-pcsw3vmx 358 76 expression expression NN cord-273505-pcsw3vmx 358 77 Pathological pathological JJ cord-273505-pcsw3vmx 358 78 findings finding NNS cord-273505-pcsw3vmx 358 79 of of IN cord-273505-pcsw3vmx 358 80 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 358 81 associated associate VBN cord-273505-pcsw3vmx 358 82 with with IN cord-273505-pcsw3vmx 358 83 acute acute JJ cord-273505-pcsw3vmx 358 84 respiratory respiratory JJ cord-273505-pcsw3vmx 358 85 distress distress NN cord-273505-pcsw3vmx 358 86 syndrome syndrome NN cord-273505-pcsw3vmx 359 1 TH17 TH17 NNP cord-273505-pcsw3vmx 359 2 responses response NNS cord-273505-pcsw3vmx 359 3 in in IN cord-273505-pcsw3vmx 359 4 cytokine cytokine NN cord-273505-pcsw3vmx 359 5 storm storm NN cord-273505-pcsw3vmx 359 6 of of IN cord-273505-pcsw3vmx 359 7 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 359 8 : : : cord-273505-pcsw3vmx 359 9 an an DT cord-273505-pcsw3vmx 359 10 emerging emerge VBG cord-273505-pcsw3vmx 359 11 target target NN cord-273505-pcsw3vmx 359 12 of of IN cord-273505-pcsw3vmx 359 13 JAK2 JAK2 NNP cord-273505-pcsw3vmx 359 14 inhibitor inhibitor NN cord-273505-pcsw3vmx 359 15 Fedratinib Fedratinib NNP cord-273505-pcsw3vmx 359 16 Plasma Plasma NNP cord-273505-pcsw3vmx 359 17 inflammatory inflammatory JJ cord-273505-pcsw3vmx 359 18 cytokines cytokine NNS cord-273505-pcsw3vmx 359 19 and and CC cord-273505-pcsw3vmx 359 20 chemokines chemokine NNS cord-273505-pcsw3vmx 359 21 in in IN cord-273505-pcsw3vmx 359 22 severe severe JJ cord-273505-pcsw3vmx 359 23 acute acute JJ cord-273505-pcsw3vmx 359 24 respiratory respiratory JJ cord-273505-pcsw3vmx 359 25 syndrome syndrome NN cord-273505-pcsw3vmx 359 26 MERS MERS NNP cord-273505-pcsw3vmx 359 27 - - HYPH cord-273505-pcsw3vmx 359 28 CoV cov NN cord-273505-pcsw3vmx 359 29 infection infection NN cord-273505-pcsw3vmx 359 30 in in IN cord-273505-pcsw3vmx 359 31 humans human NNS cord-273505-pcsw3vmx 359 32 is be VBZ cord-273505-pcsw3vmx 359 33 associated associate VBN cord-273505-pcsw3vmx 359 34 with with IN cord-273505-pcsw3vmx 359 35 a a DT cord-273505-pcsw3vmx 359 36 proinflammatory proinflammatory JJ cord-273505-pcsw3vmx 359 37 Th1 th1 NN cord-273505-pcsw3vmx 359 38 and and CC cord-273505-pcsw3vmx 359 39 Th17 Th17 NNP cord-273505-pcsw3vmx 359 40 cytokine cytokine NN cord-273505-pcsw3vmx 359 41 profile profile NN cord-273505-pcsw3vmx 359 42 Severe severe JJ cord-273505-pcsw3vmx 359 43 influenza influenza NN cord-273505-pcsw3vmx 359 44 : : : cord-273505-pcsw3vmx 359 45 overview overview VB cord-273505-pcsw3vmx 359 46 in in IN cord-273505-pcsw3vmx 359 47 critically critically RB cord-273505-pcsw3vmx 359 48 ill ill JJ cord-273505-pcsw3vmx 359 49 patients patient NNS cord-273505-pcsw3vmx 359 50 Th1 Th1 NNP cord-273505-pcsw3vmx 359 51 and and CC cord-273505-pcsw3vmx 359 52 Th17 Th17 NNP cord-273505-pcsw3vmx 359 53 hypercytokinemia hypercytokinemia NNP cord-273505-pcsw3vmx 359 54 as as IN cord-273505-pcsw3vmx 359 55 early early JJ cord-273505-pcsw3vmx 359 56 host host NN cord-273505-pcsw3vmx 359 57 response response NN cord-273505-pcsw3vmx 359 58 signature signature NN cord-273505-pcsw3vmx 359 59 in in IN cord-273505-pcsw3vmx 359 60 severe severe JJ cord-273505-pcsw3vmx 359 61 pandemic pandemic NN cord-273505-pcsw3vmx 359 62 influenza influenza NN cord-273505-pcsw3vmx 359 63 Elevated elevate VBN cord-273505-pcsw3vmx 359 64 Th1 Th1 NNP cord-273505-pcsw3vmx 359 65 / / SYM cord-273505-pcsw3vmx 359 66 Th2 th2 CD cord-273505-pcsw3vmx 359 67 cell cell NN cord-273505-pcsw3vmx 359 68 ratios ratio NNS cord-273505-pcsw3vmx 359 69 in in IN cord-273505-pcsw3vmx 359 70 a a DT cord-273505-pcsw3vmx 359 71 pregnant pregnant JJ cord-273505-pcsw3vmx 359 72 woman woman NN cord-273505-pcsw3vmx 359 73 with with IN cord-273505-pcsw3vmx 359 74 a a DT cord-273505-pcsw3vmx 359 75 history history NN cord-273505-pcsw3vmx 359 76 of of IN cord-273505-pcsw3vmx 359 77 RSA RSA NNP cord-273505-pcsw3vmx 359 78 , , , cord-273505-pcsw3vmx 359 79 secondary secondary JJ cord-273505-pcsw3vmx 359 80 Sjogren Sjogren NNP cord-273505-pcsw3vmx 359 81 's 's POS cord-273505-pcsw3vmx 359 82 syndrome syndrome NN cord-273505-pcsw3vmx 359 83 and and CC cord-273505-pcsw3vmx 359 84 rheumatoid rheumatoid NN cord-273505-pcsw3vmx 359 85 arthritis arthritis NN cord-273505-pcsw3vmx 359 86 complicated complicate VBN cord-273505-pcsw3vmx 359 87 with with IN cord-273505-pcsw3vmx 359 88 one one CD cord-273505-pcsw3vmx 359 89 fetal fetal JJ cord-273505-pcsw3vmx 359 90 demise demise NN cord-273505-pcsw3vmx 359 91 of of IN cord-273505-pcsw3vmx 359 92 twin twin JJ cord-273505-pcsw3vmx 359 93 pregnancy pregnancy NN cord-273505-pcsw3vmx 359 94 Evaluation Evaluation NNP cord-273505-pcsw3vmx 359 95 of of IN cord-273505-pcsw3vmx 359 96 intravenous intravenous JJ cord-273505-pcsw3vmx 359 97 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 359 98 resistance resistance NN cord-273505-pcsw3vmx 359 99 and and CC cord-273505-pcsw3vmx 359 100 coronary coronary JJ cord-273505-pcsw3vmx 359 101 artery artery NN cord-273505-pcsw3vmx 359 102 lesions lesion NNS cord-273505-pcsw3vmx 359 103 in in IN cord-273505-pcsw3vmx 359 104 relation relation NN cord-273505-pcsw3vmx 359 105 to to IN cord-273505-pcsw3vmx 359 106 Th1 th1 CD cord-273505-pcsw3vmx 359 107 / / SYM cord-273505-pcsw3vmx 359 108 Th2 th2 CD cord-273505-pcsw3vmx 359 109 cytokine cytokine NN cord-273505-pcsw3vmx 359 110 profiles profile NNS cord-273505-pcsw3vmx 359 111 in in IN cord-273505-pcsw3vmx 359 112 patients patient NNS cord-273505-pcsw3vmx 359 113 with with IN cord-273505-pcsw3vmx 359 114 Kawasaki Kawasaki NNP cord-273505-pcsw3vmx 359 115 disease disease NN cord-273505-pcsw3vmx 359 116 Effect effect NN cord-273505-pcsw3vmx 359 117 of of IN cord-273505-pcsw3vmx 359 118 intravenous intravenous JJ cord-273505-pcsw3vmx 359 119 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 359 120 treatment treatment NN cord-273505-pcsw3vmx 359 121 on on IN cord-273505-pcsw3vmx 359 122 the the DT cord-273505-pcsw3vmx 359 123 Th1 th1 CD cord-273505-pcsw3vmx 359 124 / / SYM cord-273505-pcsw3vmx 359 125 Th2 th2 CD cord-273505-pcsw3vmx 359 126 balance balance NN cord-273505-pcsw3vmx 359 127 in in IN cord-273505-pcsw3vmx 359 128 women woman NNS cord-273505-pcsw3vmx 359 129 with with IN cord-273505-pcsw3vmx 359 130 recurrent recurrent JJ cord-273505-pcsw3vmx 359 131 spontaneous spontaneous JJ cord-273505-pcsw3vmx 359 132 abortions abortion NNS cord-273505-pcsw3vmx 359 133 Expression expression NN cord-273505-pcsw3vmx 359 134 patterns pattern NNS cord-273505-pcsw3vmx 359 135 of of IN cord-273505-pcsw3vmx 359 136 Th1 th1 NN cord-273505-pcsw3vmx 359 137 and and CC cord-273505-pcsw3vmx 359 138 Th2 th2 CD cord-273505-pcsw3vmx 359 139 cytokine cytokine NN cord-273505-pcsw3vmx 359 140 genes gene NNS cord-273505-pcsw3vmx 359 141 in in IN cord-273505-pcsw3vmx 359 142 childhood childhood NN cord-273505-pcsw3vmx 359 143 idiopathic idiopathic JJ cord-273505-pcsw3vmx 359 144 thrombocytopenic thrombocytopenic JJ cord-273505-pcsw3vmx 359 145 purpura purpura NN cord-273505-pcsw3vmx 359 146 ( ( -LRB- cord-273505-pcsw3vmx 359 147 ITP ITP NNP cord-273505-pcsw3vmx 359 148 ) ) -RRB- cord-273505-pcsw3vmx 359 149 at at IN cord-273505-pcsw3vmx 359 150 presentation presentation NN cord-273505-pcsw3vmx 359 151 and and CC cord-273505-pcsw3vmx 359 152 their -PRON- PRP$ cord-273505-pcsw3vmx 359 153 modulation modulation NN cord-273505-pcsw3vmx 359 154 by by IN cord-273505-pcsw3vmx 359 155 intravenous intravenous JJ cord-273505-pcsw3vmx 359 156 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 359 157 G g NN cord-273505-pcsw3vmx 359 158 ( ( -LRB- cord-273505-pcsw3vmx 359 159 IVIg IVIg NNP cord-273505-pcsw3vmx 359 160 ) ) -RRB- cord-273505-pcsw3vmx 359 161 treatment treatment NN cord-273505-pcsw3vmx 359 162 : : : cord-273505-pcsw3vmx 360 1 their -PRON- PRP$ cord-273505-pcsw3vmx 360 2 role role NN cord-273505-pcsw3vmx 360 3 in in IN cord-273505-pcsw3vmx 360 4 prognosis prognosis NN cord-273505-pcsw3vmx 360 5 Effect effect NN cord-273505-pcsw3vmx 360 6 of of IN cord-273505-pcsw3vmx 360 7 Intravenous Intravenous NNP cord-273505-pcsw3vmx 360 8 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 360 9 on on IN cord-273505-pcsw3vmx 360 10 Th1 th1 CD cord-273505-pcsw3vmx 360 11 and and CC cord-273505-pcsw3vmx 360 12 Th2 Th2 NNP cord-273505-pcsw3vmx 360 13 lymphocytes lymphocyte NNS cord-273505-pcsw3vmx 360 14 and and CC cord-273505-pcsw3vmx 360 15 improvement improvement NN cord-273505-pcsw3vmx 360 16 of of IN cord-273505-pcsw3vmx 360 17 pregnancy pregnancy NN cord-273505-pcsw3vmx 360 18 outcome outcome NN cord-273505-pcsw3vmx 360 19 in in IN cord-273505-pcsw3vmx 360 20 recurrent recurrent JJ cord-273505-pcsw3vmx 360 21 pregnancy pregnancy NN cord-273505-pcsw3vmx 360 22 loss loss NN cord-273505-pcsw3vmx 360 23 ( ( -LRB- cord-273505-pcsw3vmx 360 24 RPL rpl NN cord-273505-pcsw3vmx 360 25 ) ) -RRB- cord-273505-pcsw3vmx 361 1 Intravenous intravenous JJ cord-273505-pcsw3vmx 361 2 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 361 3 G g NN cord-273505-pcsw3vmx 361 4 treatment treatment NN cord-273505-pcsw3vmx 361 5 increases increase VBZ cord-273505-pcsw3vmx 361 6 live live VBP cord-273505-pcsw3vmx 361 7 birth birth NN cord-273505-pcsw3vmx 361 8 rate rate NN cord-273505-pcsw3vmx 361 9 in in IN cord-273505-pcsw3vmx 361 10 women woman NNS cord-273505-pcsw3vmx 361 11 with with IN cord-273505-pcsw3vmx 361 12 recurrent recurrent JJ cord-273505-pcsw3vmx 361 13 miscarriage miscarriage NN cord-273505-pcsw3vmx 361 14 and and CC cord-273505-pcsw3vmx 361 15 modulates modulate VBZ cord-273505-pcsw3vmx 361 16 regulatory regulatory JJ cord-273505-pcsw3vmx 361 17 and and CC cord-273505-pcsw3vmx 361 18 exhausted exhausted JJ cord-273505-pcsw3vmx 361 19 regulatory regulatory JJ cord-273505-pcsw3vmx 361 20 T t NN cord-273505-pcsw3vmx 361 21 cells cell NNS cord-273505-pcsw3vmx 361 22 frequency frequency NN cord-273505-pcsw3vmx 361 23 and and CC cord-273505-pcsw3vmx 361 24 function function VB cord-273505-pcsw3vmx 361 25 Modulatory modulatory JJ cord-273505-pcsw3vmx 361 26 effect effect NN cord-273505-pcsw3vmx 361 27 of of IN cord-273505-pcsw3vmx 361 28 intravenous intravenous JJ cord-273505-pcsw3vmx 361 29 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 361 30 on on IN cord-273505-pcsw3vmx 361 31 Th17 Th17 NNP cord-273505-pcsw3vmx 361 32 / / SYM cord-273505-pcsw3vmx 361 33 Treg Treg NNP cord-273505-pcsw3vmx 361 34 cell cell NN cord-273505-pcsw3vmx 361 35 balance balance NN cord-273505-pcsw3vmx 361 36 in in IN cord-273505-pcsw3vmx 361 37 women woman NNS cord-273505-pcsw3vmx 361 38 with with IN cord-273505-pcsw3vmx 362 1 unexplained unexplained JJ cord-273505-pcsw3vmx 362 2 recurrent recurrent JJ cord-273505-pcsw3vmx 362 3 spontaneous spontaneous JJ cord-273505-pcsw3vmx 362 4 abortion abortion NN cord-273505-pcsw3vmx 362 5 Intravenous Intravenous NNP cord-273505-pcsw3vmx 362 6 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 362 7 ( ( -LRB- cord-273505-pcsw3vmx 362 8 IVIG IVIG NNP cord-273505-pcsw3vmx 362 9 ) ) -RRB- cord-273505-pcsw3vmx 362 10 treatment treatment NN cord-273505-pcsw3vmx 362 11 modulates modulate VBZ cord-273505-pcsw3vmx 362 12 peripheral peripheral JJ cord-273505-pcsw3vmx 362 13 blood blood NN cord-273505-pcsw3vmx 362 14 Th17 Th17 NNP cord-273505-pcsw3vmx 362 15 and and CC cord-273505-pcsw3vmx 362 16 regulatory regulatory JJ cord-273505-pcsw3vmx 362 17 T t NN cord-273505-pcsw3vmx 362 18 cells cell NNS cord-273505-pcsw3vmx 362 19 in in IN cord-273505-pcsw3vmx 362 20 recurrent recurrent JJ cord-273505-pcsw3vmx 362 21 miscarriage miscarriage NN cord-273505-pcsw3vmx 362 22 patients patient NNS cord-273505-pcsw3vmx 362 23 : : : cord-273505-pcsw3vmx 362 24 non non JJ cord-273505-pcsw3vmx 362 25 randomized randomized JJ cord-273505-pcsw3vmx 362 26 , , , cord-273505-pcsw3vmx 362 27 open open JJ cord-273505-pcsw3vmx 362 28 - - HYPH cord-273505-pcsw3vmx 362 29 label label NN cord-273505-pcsw3vmx 362 30 clinical clinical JJ cord-273505-pcsw3vmx 362 31 trial trial NN cord-273505-pcsw3vmx 362 32 Regulatory Regulatory NNP cord-273505-pcsw3vmx 362 33 T T NNP cord-273505-pcsw3vmx 362 34 cells cell NNS cord-273505-pcsw3vmx 362 35 improve improve VBP cord-273505-pcsw3vmx 362 36 pregnancy pregnancy NN cord-273505-pcsw3vmx 362 37 rate rate NN cord-273505-pcsw3vmx 362 38 in in IN cord-273505-pcsw3vmx 362 39 RIF RIF NNP cord-273505-pcsw3vmx 362 40 patients patient NNS cord-273505-pcsw3vmx 362 41 after after IN cord-273505-pcsw3vmx 362 42 additional additional JJ cord-273505-pcsw3vmx 362 43 IVIG IVIG NNP cord-273505-pcsw3vmx 362 44 treatment treatment NN cord-273505-pcsw3vmx 362 45 Th17-and Th17-and NNP cord-273505-pcsw3vmx 362 46 Treg Treg NNP cord-273505-pcsw3vmx 362 47 - - HYPH cord-273505-pcsw3vmx 362 48 related relate VBN cord-273505-pcsw3vmx 362 49 cytokine cytokine NN cord-273505-pcsw3vmx 362 50 and and CC cord-273505-pcsw3vmx 362 51 mRNA mrna NN cord-273505-pcsw3vmx 362 52 expression expression NN cord-273505-pcsw3vmx 362 53 are be VBP cord-273505-pcsw3vmx 362 54 associated associate VBN cord-273505-pcsw3vmx 362 55 with with IN cord-273505-pcsw3vmx 362 56 acute acute JJ cord-273505-pcsw3vmx 362 57 and and CC cord-273505-pcsw3vmx 362 58 resolving resolve VBG cord-273505-pcsw3vmx 362 59 Kawasaki Kawasaki NNP cord-273505-pcsw3vmx 362 60 disease disease NN cord-273505-pcsw3vmx 363 1 Intravenous intravenous JJ cord-273505-pcsw3vmx 363 2 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 363 3 exerts exert VBZ cord-273505-pcsw3vmx 363 4 reciprocal reciprocal JJ cord-273505-pcsw3vmx 363 5 regulation regulation NN cord-273505-pcsw3vmx 363 6 of of IN cord-273505-pcsw3vmx 363 7 Th1 th1 CD cord-273505-pcsw3vmx 363 8 / / SYM cord-273505-pcsw3vmx 363 9 Th17 th17 CD cord-273505-pcsw3vmx 363 10 cells cell NNS cord-273505-pcsw3vmx 363 11 and and CC cord-273505-pcsw3vmx 363 12 regulatory regulatory JJ cord-273505-pcsw3vmx 363 13 T t NN cord-273505-pcsw3vmx 363 14 cells cell NNS cord-273505-pcsw3vmx 363 15 in in IN cord-273505-pcsw3vmx 363 16 Guillain Guillain NNP cord-273505-pcsw3vmx 363 17 - - HYPH cord-273505-pcsw3vmx 363 18 Barre Barre NNP cord-273505-pcsw3vmx 363 19 syndrome syndrome NN cord-273505-pcsw3vmx 363 20 patients patient VBZ cord-273505-pcsw3vmx 363 21 High high JJ cord-273505-pcsw3vmx 363 22 - - HYPH cord-273505-pcsw3vmx 363 23 dose dose NN cord-273505-pcsw3vmx 363 24 intravenous intravenous JJ cord-273505-pcsw3vmx 363 25 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 363 26 therapy therapy NN cord-273505-pcsw3vmx 363 27 for for IN cord-273505-pcsw3vmx 363 28 eosinophilic eosinophilic JJ cord-273505-pcsw3vmx 363 29 granulomatosis granulomatosis NN cord-273505-pcsw3vmx 363 30 with with IN cord-273505-pcsw3vmx 363 31 polyangiitis polyangiitis NNP cord-273505-pcsw3vmx 363 32 Sialylation Sialylation NNP cord-273505-pcsw3vmx 363 33 may may MD cord-273505-pcsw3vmx 363 34 be be VB cord-273505-pcsw3vmx 363 35 dispensable dispensable JJ cord-273505-pcsw3vmx 363 36 for for IN cord-273505-pcsw3vmx 363 37 reciprocal reciprocal JJ cord-273505-pcsw3vmx 363 38 modulation modulation NN cord-273505-pcsw3vmx 363 39 of of IN cord-273505-pcsw3vmx 363 40 helper helper NN cord-273505-pcsw3vmx 363 41 T t NN cord-273505-pcsw3vmx 363 42 cells cell NNS cord-273505-pcsw3vmx 363 43 by by IN cord-273505-pcsw3vmx 363 44 intravenous intravenous JJ cord-273505-pcsw3vmx 363 45 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 363 46 Intravenous Intravenous NNP cord-273505-pcsw3vmx 363 47 gammaglobulin gammaglobulin NNP cord-273505-pcsw3vmx 363 48 inhibits inhibit VBZ cord-273505-pcsw3vmx 363 49 encephalitogenic encephalitogenic NNP cord-273505-pcsw3vmx 363 50 potential potential NN cord-273505-pcsw3vmx 363 51 of of IN cord-273505-pcsw3vmx 363 52 pathogenic pathogenic JJ cord-273505-pcsw3vmx 363 53 T t NN cord-273505-pcsw3vmx 363 54 cells cell NNS cord-273505-pcsw3vmx 363 55 and and CC cord-273505-pcsw3vmx 363 56 interferes interfere VBZ cord-273505-pcsw3vmx 363 57 with with IN cord-273505-pcsw3vmx 363 58 their -PRON- PRP$ cord-273505-pcsw3vmx 363 59 trafficking trafficking NN cord-273505-pcsw3vmx 363 60 to to IN cord-273505-pcsw3vmx 363 61 the the DT cord-273505-pcsw3vmx 363 62 central central JJ cord-273505-pcsw3vmx 363 63 nervous nervous JJ cord-273505-pcsw3vmx 363 64 system system NN cord-273505-pcsw3vmx 363 65 , , , cord-273505-pcsw3vmx 363 66 implicating implicate VBG cord-273505-pcsw3vmx 363 67 sphingosine-1 sphingosine-1 NNP cord-273505-pcsw3vmx 363 68 phosphate phosphate NN cord-273505-pcsw3vmx 363 69 receptor receptor NN cord-273505-pcsw3vmx 363 70 1-mammalian 1-mammalian CD cord-273505-pcsw3vmx 363 71 target target NN cord-273505-pcsw3vmx 363 72 of of IN cord-273505-pcsw3vmx 363 73 rapamycin rapamycin NN cord-273505-pcsw3vmx 363 74 axis axis NN cord-273505-pcsw3vmx 363 75 Monomeric Monomeric NNP cord-273505-pcsw3vmx 363 76 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 363 77 a a DT cord-273505-pcsw3vmx 363 78 from from IN cord-273505-pcsw3vmx 363 79 plasma plasma NN cord-273505-pcsw3vmx 363 80 inhibits inhibit VBZ cord-273505-pcsw3vmx 363 81 human human JJ cord-273505-pcsw3vmx 363 82 th17 th17 NN cord-273505-pcsw3vmx 363 83 responses response NNS cord-273505-pcsw3vmx 363 84 in in IN cord-273505-pcsw3vmx 363 85 vitro vitro FW cord-273505-pcsw3vmx 363 86 independent independent JJ cord-273505-pcsw3vmx 363 87 of of IN cord-273505-pcsw3vmx 363 88 FcalphaRI FcalphaRI NNP cord-273505-pcsw3vmx 363 89 and and CC cord-273505-pcsw3vmx 363 90 DC DC NNP cord-273505-pcsw3vmx 363 91 - - HYPH cord-273505-pcsw3vmx 363 92 SIGN SIGN NNP cord-273505-pcsw3vmx 363 93 . . . cord-273505-pcsw3vmx 364 1 Front Front NNP cord-273505-pcsw3vmx 364 2 Immunol Immunol NNP cord-273505-pcsw3vmx 364 3 Intravenous Intravenous NNP cord-273505-pcsw3vmx 364 4 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 364 5 attenuates attenuate VBZ cord-273505-pcsw3vmx 364 6 airway airway JJ cord-273505-pcsw3vmx 364 7 inflammation inflammation NN cord-273505-pcsw3vmx 364 8 through through IN cord-273505-pcsw3vmx 364 9 induction induction NN cord-273505-pcsw3vmx 364 10 of of IN cord-273505-pcsw3vmx 364 11 forkhead forkhead NNP cord-273505-pcsw3vmx 364 12 box box NNP cord-273505-pcsw3vmx 364 13 protein protein NNP cord-273505-pcsw3vmx 364 14 3-positive 3-positive CD cord-273505-pcsw3vmx 364 15 regulatory regulatory JJ cord-273505-pcsw3vmx 364 16 T t NN cord-273505-pcsw3vmx 364 17 cells cell NNS cord-273505-pcsw3vmx 365 1 Intravenous intravenous JJ cord-273505-pcsw3vmx 365 2 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 365 3 expands expand VBZ cord-273505-pcsw3vmx 365 4 regulatory regulatory JJ cord-273505-pcsw3vmx 365 5 T t NN cord-273505-pcsw3vmx 365 6 cells cell NNS cord-273505-pcsw3vmx 365 7 via via IN cord-273505-pcsw3vmx 365 8 induction induction NN cord-273505-pcsw3vmx 365 9 of of IN cord-273505-pcsw3vmx 365 10 cyclooxygenase-2-dependent cyclooxygenase-2-dependent NNP cord-273505-pcsw3vmx 365 11 prostaglandin prostaglandin NN cord-273505-pcsw3vmx 365 12 E2 E2 NNP cord-273505-pcsw3vmx 365 13 in in IN cord-273505-pcsw3vmx 365 14 human human JJ cord-273505-pcsw3vmx 365 15 dendritic dendritic JJ cord-273505-pcsw3vmx 365 16 cells cell NNS cord-273505-pcsw3vmx 366 1 Contrasting contrast VBG cord-273505-pcsw3vmx 366 2 mechanisms mechanism NNS cord-273505-pcsw3vmx 366 3 of of IN cord-273505-pcsw3vmx 366 4 interferon interferon NN cord-273505-pcsw3vmx 366 5 - - HYPH cord-273505-pcsw3vmx 366 6 alpha alpha NN cord-273505-pcsw3vmx 366 7 inhibition inhibition NN cord-273505-pcsw3vmx 366 8 by by IN cord-273505-pcsw3vmx 366 9 intravenous intravenous JJ cord-273505-pcsw3vmx 366 10 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 366 11 after after IN cord-273505-pcsw3vmx 366 12 induction induction NN cord-273505-pcsw3vmx 366 13 by by IN cord-273505-pcsw3vmx 366 14 immune immune JJ cord-273505-pcsw3vmx 366 15 complexes complex NNS cord-273505-pcsw3vmx 366 16 versus versus IN cord-273505-pcsw3vmx 366 17 Toll toll NN cord-273505-pcsw3vmx 366 18 - - HYPH cord-273505-pcsw3vmx 366 19 like like JJ cord-273505-pcsw3vmx 366 20 receptor receptor NN cord-273505-pcsw3vmx 366 21 agonists agonist NNS cord-273505-pcsw3vmx 367 1 Tregitope Tregitope NNP cord-273505-pcsw3vmx 367 2 update update NN cord-273505-pcsw3vmx 367 3 : : : cord-273505-pcsw3vmx 367 4 mechanism mechanism NN cord-273505-pcsw3vmx 367 5 of of IN cord-273505-pcsw3vmx 367 6 action action NN cord-273505-pcsw3vmx 367 7 parallels parallel NNS cord-273505-pcsw3vmx 367 8 IVIg ivig VBP cord-273505-pcsw3vmx 367 9 Mechanisms Mechanisms NNPS cord-273505-pcsw3vmx 367 10 of of IN cord-273505-pcsw3vmx 367 11 immune immune JJ cord-273505-pcsw3vmx 367 12 regulation regulation NN cord-273505-pcsw3vmx 367 13 by by IN cord-273505-pcsw3vmx 367 14 IVIG IVIG NNP cord-273505-pcsw3vmx 367 15 Tregitope Tregitope NNP cord-273505-pcsw3vmx 367 16 peptides peptide NNS cord-273505-pcsw3vmx 367 17 : : : cord-273505-pcsw3vmx 367 18 the the DT cord-273505-pcsw3vmx 367 19 active active JJ cord-273505-pcsw3vmx 367 20 pharmaceutical pharmaceutical JJ cord-273505-pcsw3vmx 367 21 ingredient ingredient NN cord-273505-pcsw3vmx 367 22 of of IN cord-273505-pcsw3vmx 367 23 IVIG IVIG NNP cord-273505-pcsw3vmx 367 24 ? ? . cord-273505-pcsw3vmx 368 1 New new JJ cord-273505-pcsw3vmx 368 2 fronts front NNS cord-273505-pcsw3vmx 368 3 emerge emerge VBP cord-273505-pcsw3vmx 368 4 in in IN cord-273505-pcsw3vmx 368 5 the the DT cord-273505-pcsw3vmx 368 6 influenza influenza NN cord-273505-pcsw3vmx 368 7 cytokine cytokine NN cord-273505-pcsw3vmx 368 8 storm storm NN cord-273505-pcsw3vmx 368 9 Animal Animal NNP cord-273505-pcsw3vmx 368 10 model model NN cord-273505-pcsw3vmx 368 11 of of IN cord-273505-pcsw3vmx 368 12 respiratory respiratory JJ cord-273505-pcsw3vmx 368 13 syncytial syncytial JJ cord-273505-pcsw3vmx 368 14 virus virus NN cord-273505-pcsw3vmx 368 15 : : : cord-273505-pcsw3vmx 368 16 CD8 CD8 NNP cord-273505-pcsw3vmx 368 17 + + CC cord-273505-pcsw3vmx 368 18 T T NNP cord-273505-pcsw3vmx 368 19 cells cell NNS cord-273505-pcsw3vmx 368 20 cause cause VBP cord-273505-pcsw3vmx 368 21 a a DT cord-273505-pcsw3vmx 368 22 cytokine cytokine NN cord-273505-pcsw3vmx 368 23 storm storm NN cord-273505-pcsw3vmx 368 24 that that WDT cord-273505-pcsw3vmx 368 25 is be VBZ cord-273505-pcsw3vmx 368 26 chemically chemically RB cord-273505-pcsw3vmx 368 27 tractable tractable JJ cord-273505-pcsw3vmx 368 28 by by IN cord-273505-pcsw3vmx 368 29 sphingosine-1-phosphate sphingosine-1-phosphate NNP cord-273505-pcsw3vmx 368 30 1 1 CD cord-273505-pcsw3vmx 368 31 receptor receptor NN cord-273505-pcsw3vmx 368 32 agonist agonist NN cord-273505-pcsw3vmx 368 33 therapy therapy NN cord-273505-pcsw3vmx 368 34 Increased increase VBN cord-273505-pcsw3vmx 368 35 expression expression NN cord-273505-pcsw3vmx 368 36 of of IN cord-273505-pcsw3vmx 368 37 CD8 CD8 NNP cord-273505-pcsw3vmx 368 38 marker marker NN cord-273505-pcsw3vmx 368 39 on on IN cord-273505-pcsw3vmx 368 40 T T NNP cord-273505-pcsw3vmx 368 41 - - HYPH cord-273505-pcsw3vmx 368 42 cells cell NNS cord-273505-pcsw3vmx 368 43 in in IN cord-273505-pcsw3vmx 368 44 COVID-19 covid-19 CD cord-273505-pcsw3vmx 368 45 patients patient NNS cord-273505-pcsw3vmx 369 1 The the DT cord-273505-pcsw3vmx 369 2 cytokine cytokine NN cord-273505-pcsw3vmx 369 3 release release NN cord-273505-pcsw3vmx 369 4 syndrome syndrome NN cord-273505-pcsw3vmx 369 5 ( ( -LRB- cord-273505-pcsw3vmx 369 6 CRS CRS NNP cord-273505-pcsw3vmx 369 7 ) ) -RRB- cord-273505-pcsw3vmx 369 8 of of IN cord-273505-pcsw3vmx 369 9 severe severe JJ cord-273505-pcsw3vmx 369 10 COVID-19 covid-19 NN cord-273505-pcsw3vmx 369 11 and and CC cord-273505-pcsw3vmx 369 12 Interleukin-6 Interleukin-6 NNP cord-273505-pcsw3vmx 370 1 receptor receptor NN cord-273505-pcsw3vmx 370 2 ( ( -LRB- cord-273505-pcsw3vmx 370 3 IL-6R IL-6R NNP cord-273505-pcsw3vmx 370 4 ) ) -RRB- cord-273505-pcsw3vmx 370 5 antagonist antagonist NN cord-273505-pcsw3vmx 371 1 Tocilizumab Tocilizumab NNP cord-273505-pcsw3vmx 371 2 may may MD cord-273505-pcsw3vmx 371 3 be be VB cord-273505-pcsw3vmx 371 4 the the DT cord-273505-pcsw3vmx 371 5 key key NN cord-273505-pcsw3vmx 371 6 to to TO cord-273505-pcsw3vmx 371 7 reduce reduce VB cord-273505-pcsw3vmx 371 8 the the DT cord-273505-pcsw3vmx 371 9 mortality mortality NN cord-273505-pcsw3vmx 372 1 Intravenous intravenous JJ cord-273505-pcsw3vmx 372 2 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 372 3 treatment treatment NN cord-273505-pcsw3vmx 372 4 responsiveness responsiveness NN cord-273505-pcsw3vmx 372 5 depends depend VBZ cord-273505-pcsw3vmx 372 6 on on IN cord-273505-pcsw3vmx 372 7 the the DT cord-273505-pcsw3vmx 372 8 degree degree NN cord-273505-pcsw3vmx 372 9 of of IN cord-273505-pcsw3vmx 372 10 CD8 CD8 NNP cord-273505-pcsw3vmx 372 11 + + CC cord-273505-pcsw3vmx 372 12 T T NNP cord-273505-pcsw3vmx 372 13 cell cell NN cord-273505-pcsw3vmx 372 14 activation activation NN cord-273505-pcsw3vmx 372 15 in in IN cord-273505-pcsw3vmx 372 16 Kawasaki Kawasaki NNP cord-273505-pcsw3vmx 372 17 disease disease NN cord-273505-pcsw3vmx 372 18 Recovery Recovery NNP cord-273505-pcsw3vmx 372 19 of of IN cord-273505-pcsw3vmx 372 20 the the DT cord-273505-pcsw3vmx 372 21 T t NN cord-273505-pcsw3vmx 372 22 - - HYPH cord-273505-pcsw3vmx 372 23 cell cell NN cord-273505-pcsw3vmx 372 24 repertoire repertoire NN cord-273505-pcsw3vmx 372 25 in in IN cord-273505-pcsw3vmx 372 26 CIDP CIDP NNP cord-273505-pcsw3vmx 372 27 by by IN cord-273505-pcsw3vmx 372 28 IV IV NNP cord-273505-pcsw3vmx 372 29 immunoglobulins immunoglobulin NNS cord-273505-pcsw3vmx 372 30 Intravenous intravenous JJ cord-273505-pcsw3vmx 372 31 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 372 32 ( ( -LRB- cord-273505-pcsw3vmx 372 33 IVIg ivig ADD cord-273505-pcsw3vmx 372 34 ) ) -RRB- cord-273505-pcsw3vmx 372 35 inhibits inhibit VBZ cord-273505-pcsw3vmx 372 36 CD8 CD8 NNP cord-273505-pcsw3vmx 372 37 cytotoxic cytotoxic JJ cord-273505-pcsw3vmx 372 38 T T NNP cord-273505-pcsw3vmx 372 39 - - HYPH cord-273505-pcsw3vmx 372 40 cell cell NN cord-273505-pcsw3vmx 372 41 activation activation NN cord-273505-pcsw3vmx 373 1 Intravenous intravenous JJ cord-273505-pcsw3vmx 373 2 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 373 3 modulates modulate VBZ cord-273505-pcsw3vmx 373 4 the the DT cord-273505-pcsw3vmx 373 5 expansion expansion NN cord-273505-pcsw3vmx 373 6 and and CC cord-273505-pcsw3vmx 373 7 cytotoxicity cytotoxicity NN cord-273505-pcsw3vmx 373 8 of of IN cord-273505-pcsw3vmx 373 9 CD8 CD8 NNP cord-273505-pcsw3vmx 373 10 + + CC cord-273505-pcsw3vmx 373 11 T T NNP cord-273505-pcsw3vmx 373 12 cells cell NNS cord-273505-pcsw3vmx 374 1 Exogenous exogenous JJ cord-273505-pcsw3vmx 374 2 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 374 3 downregulates downregulate VBZ cord-273505-pcsw3vmx 374 4 T t NN cord-273505-pcsw3vmx 374 5 - - HYPH cord-273505-pcsw3vmx 374 6 cell cell NN cord-273505-pcsw3vmx 374 7 receptor receptor NN cord-273505-pcsw3vmx 374 8 signaling signal VBG cord-273505-pcsw3vmx 374 9 and and CC cord-273505-pcsw3vmx 374 10 cytokine cytokine NN cord-273505-pcsw3vmx 374 11 production production NN cord-273505-pcsw3vmx 374 12 Antibodies antibody NNS cord-273505-pcsw3vmx 374 13 to to IN cord-273505-pcsw3vmx 374 14 a a DT cord-273505-pcsw3vmx 374 15 conserved conserved JJ cord-273505-pcsw3vmx 374 16 region region NN cord-273505-pcsw3vmx 374 17 of of IN cord-273505-pcsw3vmx 374 18 HLA HLA NNP cord-273505-pcsw3vmx 374 19 class class NN cord-273505-pcsw3vmx 374 20 I -PRON- PRP cord-273505-pcsw3vmx 374 21 molecules molecule NNS cord-273505-pcsw3vmx 374 22 , , , cord-273505-pcsw3vmx 374 23 capable capable JJ cord-273505-pcsw3vmx 374 24 of of IN cord-273505-pcsw3vmx 374 25 modulating modulate VBG cord-273505-pcsw3vmx 374 26 CD8 CD8 NNP cord-273505-pcsw3vmx 374 27 T T NNP cord-273505-pcsw3vmx 374 28 cell cell NN cord-273505-pcsw3vmx 374 29 - - HYPH cord-273505-pcsw3vmx 374 30 mediated mediate VBN cord-273505-pcsw3vmx 374 31 function function NN cord-273505-pcsw3vmx 374 32 , , , cord-273505-pcsw3vmx 374 33 are be VBP cord-273505-pcsw3vmx 374 34 present present JJ cord-273505-pcsw3vmx 374 35 in in IN cord-273505-pcsw3vmx 374 36 pooled pool VBN cord-273505-pcsw3vmx 374 37 normal normal JJ cord-273505-pcsw3vmx 374 38 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 374 39 for for IN cord-273505-pcsw3vmx 374 40 therapeutic therapeutic JJ cord-273505-pcsw3vmx 374 41 use use NN cord-273505-pcsw3vmx 374 42 IL-6 IL-6 NNP cord-273505-pcsw3vmx 374 43 in in IN cord-273505-pcsw3vmx 374 44 inflammation inflammation NN cord-273505-pcsw3vmx 374 45 , , , cord-273505-pcsw3vmx 374 46 immunity immunity NN cord-273505-pcsw3vmx 374 47 , , , cord-273505-pcsw3vmx 374 48 and and CC cord-273505-pcsw3vmx 374 49 disease disease NN cord-273505-pcsw3vmx 374 50 Relationships relationship NNS cord-273505-pcsw3vmx 374 51 between between IN cord-273505-pcsw3vmx 374 52 B b NN cord-273505-pcsw3vmx 374 53 cell cell NN cord-273505-pcsw3vmx 374 54 cytokine cytokine NN cord-273505-pcsw3vmx 374 55 production production NN cord-273505-pcsw3vmx 374 56 in in IN cord-273505-pcsw3vmx 374 57 secondary secondary JJ cord-273505-pcsw3vmx 374 58 lymphoid lymphoid JJ cord-273505-pcsw3vmx 374 59 follicles follicle NNS cord-273505-pcsw3vmx 374 60 and and CC cord-273505-pcsw3vmx 374 61 apoptosis apoptosis NN cord-273505-pcsw3vmx 374 62 of of IN cord-273505-pcsw3vmx 374 63 germinal germinal JJ cord-273505-pcsw3vmx 374 64 center center NN cord-273505-pcsw3vmx 374 65 B B NNP cord-273505-pcsw3vmx 374 66 lymphocytes lymphocyte NNS cord-273505-pcsw3vmx 374 67 B b NN cord-273505-pcsw3vmx 374 68 cell cell NN cord-273505-pcsw3vmx 374 69 - - HYPH cord-273505-pcsw3vmx 374 70 derived derive VBN cord-273505-pcsw3vmx 374 71 IL-6 IL-6 NNP cord-273505-pcsw3vmx 374 72 initiates initiate VBZ cord-273505-pcsw3vmx 374 73 spontaneous spontaneous JJ cord-273505-pcsw3vmx 374 74 germinal germinal JJ cord-273505-pcsw3vmx 374 75 center center NN cord-273505-pcsw3vmx 374 76 formation formation NN cord-273505-pcsw3vmx 374 77 during during IN cord-273505-pcsw3vmx 374 78 systemic systemic JJ cord-273505-pcsw3vmx 374 79 autoimmunity autoimmunity IN cord-273505-pcsw3vmx 374 80 Dysregulation Dysregulation NNP cord-273505-pcsw3vmx 374 81 of of IN cord-273505-pcsw3vmx 374 82 immune immune JJ cord-273505-pcsw3vmx 374 83 response response NN cord-273505-pcsw3vmx 374 84 in in IN cord-273505-pcsw3vmx 374 85 patients patient NNS cord-273505-pcsw3vmx 374 86 with with IN cord-273505-pcsw3vmx 374 87 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 374 88 in in IN cord-273505-pcsw3vmx 374 89 Wuhan Wuhan NNP cord-273505-pcsw3vmx 374 90 , , , cord-273505-pcsw3vmx 374 91 China China NNP cord-273505-pcsw3vmx 374 92 Immune Immune NNP cord-273505-pcsw3vmx 374 93 cell cell NN cord-273505-pcsw3vmx 374 94 profiling profiling NN cord-273505-pcsw3vmx 374 95 of of IN cord-273505-pcsw3vmx 374 96 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 374 97 patients patient NNS cord-273505-pcsw3vmx 374 98 in in IN cord-273505-pcsw3vmx 374 99 the the DT cord-273505-pcsw3vmx 374 100 recovery recovery NN cord-273505-pcsw3vmx 374 101 stage stage NN cord-273505-pcsw3vmx 374 102 by by IN cord-273505-pcsw3vmx 374 103 singlecell singlecell NNP cord-273505-pcsw3vmx 374 104 sequencing sequencing NN cord-273505-pcsw3vmx 374 105 . . . cord-273505-pcsw3vmx 375 1 medRxiv medRxiv NNS cord-273505-pcsw3vmx 376 1 A a DT cord-273505-pcsw3vmx 376 2 possible possible JJ cord-273505-pcsw3vmx 376 3 role role NN cord-273505-pcsw3vmx 376 4 for for IN cord-273505-pcsw3vmx 376 5 B b NN cord-273505-pcsw3vmx 376 6 cells cell NNS cord-273505-pcsw3vmx 376 7 in in IN cord-273505-pcsw3vmx 376 8 COVID-19 covid-19 NN cord-273505-pcsw3vmx 376 9 ? ? . cord-273505-pcsw3vmx 377 1 Lesson lesson NN cord-273505-pcsw3vmx 377 2 from from IN cord-273505-pcsw3vmx 377 3 patients patient NNS cord-273505-pcsw3vmx 377 4 with with IN cord-273505-pcsw3vmx 377 5 agammaglobulinemia agammaglobulinemia NN cord-273505-pcsw3vmx 377 6 Two two CD cord-273505-pcsw3vmx 377 7 X x NN cord-273505-pcsw3vmx 377 8 - - HYPH cord-273505-pcsw3vmx 377 9 linked link VBN cord-273505-pcsw3vmx 377 10 agammaglobulinemia agammaglobulinemia NN cord-273505-pcsw3vmx 377 11 patients patient NNS cord-273505-pcsw3vmx 377 12 develop develop VBP cord-273505-pcsw3vmx 377 13 pneumonia pneumonia NN cord-273505-pcsw3vmx 377 14 as as IN cord-273505-pcsw3vmx 377 15 COVID-19 covid-19 JJ cord-273505-pcsw3vmx 377 16 manifestation manifestation NN cord-273505-pcsw3vmx 377 17 but but CC cord-273505-pcsw3vmx 377 18 recover recover VB cord-273505-pcsw3vmx 377 19 Review review NN cord-273505-pcsw3vmx 377 20 : : : cord-273505-pcsw3vmx 378 1 intravenous intravenous JJ cord-273505-pcsw3vmx 378 2 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 378 3 and and CC cord-273505-pcsw3vmx 378 4 B b NN cord-273505-pcsw3vmx 378 5 cells cell NNS cord-273505-pcsw3vmx 378 6 : : : cord-273505-pcsw3vmx 378 7 when when WRB cord-273505-pcsw3vmx 378 8 the the DT cord-273505-pcsw3vmx 378 9 product product NN cord-273505-pcsw3vmx 378 10 regulates regulate VBZ cord-273505-pcsw3vmx 378 11 the the DT cord-273505-pcsw3vmx 378 12 producer producer NN cord-273505-pcsw3vmx 378 13 Intravenous Intravenous NNP cord-273505-pcsw3vmx 378 14 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 378 15 induces induce VBZ cord-273505-pcsw3vmx 378 16 proliferation proliferation NN cord-273505-pcsw3vmx 378 17 and and CC cord-273505-pcsw3vmx 378 18 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 378 19 synthesis synthesis NN cord-273505-pcsw3vmx 378 20 from from IN cord-273505-pcsw3vmx 378 21 B b NN cord-273505-pcsw3vmx 378 22 cells cell NNS cord-273505-pcsw3vmx 378 23 of of IN cord-273505-pcsw3vmx 378 24 patients patient NNS cord-273505-pcsw3vmx 378 25 with with IN cord-273505-pcsw3vmx 378 26 common common JJ cord-273505-pcsw3vmx 378 27 variable variable JJ cord-273505-pcsw3vmx 378 28 immunodeficiency immunodeficiency NN cord-273505-pcsw3vmx 378 29 : : : cord-273505-pcsw3vmx 378 30 a a DT cord-273505-pcsw3vmx 378 31 mechanism mechanism NN cord-273505-pcsw3vmx 378 32 underlying underlie VBG cord-273505-pcsw3vmx 378 33 the the DT cord-273505-pcsw3vmx 378 34 beneficial beneficial JJ cord-273505-pcsw3vmx 378 35 effect effect NN cord-273505-pcsw3vmx 378 36 of of IN cord-273505-pcsw3vmx 378 37 IVIg ivig NN cord-273505-pcsw3vmx 378 38 in in IN cord-273505-pcsw3vmx 378 39 primary primary JJ cord-273505-pcsw3vmx 378 40 immunodeficiencies immunodeficiency NNS cord-273505-pcsw3vmx 379 1 Intravenous intravenous JJ cord-273505-pcsw3vmx 379 2 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 379 3 up up RB cord-273505-pcsw3vmx 379 4 - - HYPH cord-273505-pcsw3vmx 379 5 regulates regulate VBZ cord-273505-pcsw3vmx 379 6 the the DT cord-273505-pcsw3vmx 379 7 expression expression NN cord-273505-pcsw3vmx 379 8 of of IN cord-273505-pcsw3vmx 379 9 the the DT cord-273505-pcsw3vmx 379 10 inhibitory inhibitory JJ cord-273505-pcsw3vmx 379 11 FcgammaIIB FcgammaIIB NNP cord-273505-pcsw3vmx 379 12 receptor receptor NN cord-273505-pcsw3vmx 379 13 on on IN cord-273505-pcsw3vmx 379 14 B b NN cord-273505-pcsw3vmx 379 15 cells cell NNS cord-273505-pcsw3vmx 380 1 FcgammaRIIb fcgammariib JJ cord-273505-pcsw3vmx 380 2 expression expression NN cord-273505-pcsw3vmx 380 3 on on IN cord-273505-pcsw3vmx 380 4 B b NN cord-273505-pcsw3vmx 380 5 cells cell NNS cord-273505-pcsw3vmx 380 6 is be VBZ cord-273505-pcsw3vmx 380 7 associated associate VBN cord-273505-pcsw3vmx 380 8 with with IN cord-273505-pcsw3vmx 380 9 treatment treatment NN cord-273505-pcsw3vmx 380 10 efficacy efficacy NN cord-273505-pcsw3vmx 380 11 for for IN cord-273505-pcsw3vmx 380 12 acute acute JJ cord-273505-pcsw3vmx 380 13 rejection rejection NN cord-273505-pcsw3vmx 380 14 after after IN cord-273505-pcsw3vmx 380 15 kidney kidney NN cord-273505-pcsw3vmx 380 16 transplantation transplantation NN cord-273505-pcsw3vmx 380 17 IVIg ivig NN cord-273505-pcsw3vmx 380 18 - - HYPH cord-273505-pcsw3vmx 380 19 mediated mediate VBN cord-273505-pcsw3vmx 380 20 amelioration amelioration NN cord-273505-pcsw3vmx 380 21 of of IN cord-273505-pcsw3vmx 380 22 murine murine JJ cord-273505-pcsw3vmx 380 23 ITP ITP NNP cord-273505-pcsw3vmx 380 24 via via IN cord-273505-pcsw3vmx 380 25 FcgammaRIIB FcgammaRIIB NNP cord-273505-pcsw3vmx 380 26 is be VBZ cord-273505-pcsw3vmx 380 27 independent independent JJ cord-273505-pcsw3vmx 380 28 of of IN cord-273505-pcsw3vmx 380 29 SHIP1 SHIP1 NNP cord-273505-pcsw3vmx 380 30 , , , cord-273505-pcsw3vmx 380 31 SHP-1 SHP-1 NNP cord-273505-pcsw3vmx 380 32 , , , cord-273505-pcsw3vmx 380 33 and and CC cord-273505-pcsw3vmx 381 1 Btk btk NN cord-273505-pcsw3vmx 381 2 activity activity NN cord-273505-pcsw3vmx 381 3 Suppression suppression NN cord-273505-pcsw3vmx 381 4 of of IN cord-273505-pcsw3vmx 381 5 IL-4-and IL-4-and NNP cord-273505-pcsw3vmx 381 6 CD40-induced CD40-induced NNP cord-273505-pcsw3vmx 381 7 B b NN cord-273505-pcsw3vmx 381 8 - - HYPH cord-273505-pcsw3vmx 381 9 lymphocyte lymphocyte NN cord-273505-pcsw3vmx 381 10 activation activation NN cord-273505-pcsw3vmx 381 11 by by IN cord-273505-pcsw3vmx 381 12 intravenous intravenous JJ cord-273505-pcsw3vmx 381 13 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 381 14 is be VBZ cord-273505-pcsw3vmx 381 15 not not RB cord-273505-pcsw3vmx 381 16 mediated mediate VBN cord-273505-pcsw3vmx 381 17 through through IN cord-273505-pcsw3vmx 381 18 the the DT cord-273505-pcsw3vmx 381 19 inhibitory inhibitory JJ cord-273505-pcsw3vmx 381 20 IgG igg NN cord-273505-pcsw3vmx 381 21 receptor receptor NN cord-273505-pcsw3vmx 381 22 FcgammaRIIb FcgammaRIIb NNP cord-273505-pcsw3vmx 381 23 General General NNP cord-273505-pcsw3vmx 381 24 mechanism mechanism NN cord-273505-pcsw3vmx 381 25 for for IN cord-273505-pcsw3vmx 381 26 modulating modulate VBG cord-273505-pcsw3vmx 381 27 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 381 28 effector effector NN cord-273505-pcsw3vmx 381 29 function function NN cord-273505-pcsw3vmx 381 30 Crystal Crystal NNP cord-273505-pcsw3vmx 381 31 structure structure NN cord-273505-pcsw3vmx 381 32 of of IN cord-273505-pcsw3vmx 381 33 sialylated sialylated JJ cord-273505-pcsw3vmx 381 34 IgG IgG NNP cord-273505-pcsw3vmx 381 35 Fc Fc NNP cord-273505-pcsw3vmx 381 36 : : : cord-273505-pcsw3vmx 381 37 implications implication NNS cord-273505-pcsw3vmx 381 38 for for IN cord-273505-pcsw3vmx 381 39 the the DT cord-273505-pcsw3vmx 381 40 mechanism mechanism NN cord-273505-pcsw3vmx 381 41 of of IN cord-273505-pcsw3vmx 381 42 intravenous intravenous JJ cord-273505-pcsw3vmx 381 43 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 381 44 therapy therapy NN cord-273505-pcsw3vmx 381 45 IVIg IVIg NNP cord-273505-pcsw3vmx 381 46 modulates modulate VBZ cord-273505-pcsw3vmx 381 47 BCR BCR NNP cord-273505-pcsw3vmx 381 48 signaling signal VBG cord-273505-pcsw3vmx 381 49 through through IN cord-273505-pcsw3vmx 381 50 CD22 CD22 NNP cord-273505-pcsw3vmx 381 51 and and CC cord-273505-pcsw3vmx 381 52 promotes promote VBZ cord-273505-pcsw3vmx 381 53 apoptosis apoptosis NN cord-273505-pcsw3vmx 381 54 in in IN cord-273505-pcsw3vmx 381 55 mature mature JJ cord-273505-pcsw3vmx 381 56 human human JJ cord-273505-pcsw3vmx 381 57 B b NN cord-273505-pcsw3vmx 381 58 lymphocytes lymphocyte NNS cord-273505-pcsw3vmx 382 1 Sialic Sialic NNP cord-273505-pcsw3vmx 382 2 acid acid NN cord-273505-pcsw3vmx 382 3 - - HYPH cord-273505-pcsw3vmx 382 4 IVIg ivig JJ cord-273505-pcsw3vmx 382 5 targeting target VBG cord-273505-pcsw3vmx 382 6 CD22 CD22 NNP cord-273505-pcsw3vmx 382 7 IVIg ivig NN cord-273505-pcsw3vmx 382 8 attenuates attenuate VBZ cord-273505-pcsw3vmx 382 9 TLR-9 TLR-9 NNP cord-273505-pcsw3vmx 382 10 activation activation NN cord-273505-pcsw3vmx 382 11 in in IN cord-273505-pcsw3vmx 382 12 B b NN cord-273505-pcsw3vmx 382 13 cells cell NNS cord-273505-pcsw3vmx 382 14 from from IN cord-273505-pcsw3vmx 382 15 SLE SLE NNP cord-273505-pcsw3vmx 382 16 patients patient NNS cord-273505-pcsw3vmx 383 1 TLR9 tlr9 JJ cord-273505-pcsw3vmx 383 2 responses response NNS cord-273505-pcsw3vmx 383 3 of of IN cord-273505-pcsw3vmx 383 4 B b NN cord-273505-pcsw3vmx 383 5 cells cell NNS cord-273505-pcsw3vmx 383 6 are be VBP cord-273505-pcsw3vmx 383 7 repressed repress VBN cord-273505-pcsw3vmx 383 8 by by IN cord-273505-pcsw3vmx 383 9 intravenous intravenous JJ cord-273505-pcsw3vmx 383 10 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 383 11 through through IN cord-273505-pcsw3vmx 383 12 the the DT cord-273505-pcsw3vmx 383 13 recruitment recruitment NN cord-273505-pcsw3vmx 383 14 of of IN cord-273505-pcsw3vmx 383 15 phosphatase phosphatase NN cord-273505-pcsw3vmx 383 16 Prominent Prominent NNP cord-273505-pcsw3vmx 383 17 plasmacytosis plasmacytosis NN cord-273505-pcsw3vmx 383 18 following follow VBG cord-273505-pcsw3vmx 383 19 intravenous intravenous JJ cord-273505-pcsw3vmx 383 20 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 383 21 correlates correlate VBZ cord-273505-pcsw3vmx 383 22 with with IN cord-273505-pcsw3vmx 383 23 clinical clinical JJ cord-273505-pcsw3vmx 383 24 improvement improvement NN cord-273505-pcsw3vmx 383 25 in in IN cord-273505-pcsw3vmx 383 26 Guillain Guillain NNP cord-273505-pcsw3vmx 383 27 - - HYPH cord-273505-pcsw3vmx 383 28 Barré Barré NNP cord-273505-pcsw3vmx 383 29 syndrome syndrome NN cord-273505-pcsw3vmx 383 30 IVIg ivig NN cord-273505-pcsw3vmx 383 31 - - HYPH cord-273505-pcsw3vmx 383 32 induced induce VBN cord-273505-pcsw3vmx 383 33 plasmablasts plasmablast NNS cord-273505-pcsw3vmx 383 34 in in IN cord-273505-pcsw3vmx 383 35 patients patient NNS cord-273505-pcsw3vmx 383 36 with with IN cord-273505-pcsw3vmx 383 37 Guillain Guillain NNP cord-273505-pcsw3vmx 383 38 - - HYPH cord-273505-pcsw3vmx 383 39 Barre Barre NNP cord-273505-pcsw3vmx 383 40 syndrome syndrome NN cord-273505-pcsw3vmx 383 41 Modulation modulation NN cord-273505-pcsw3vmx 383 42 of of IN cord-273505-pcsw3vmx 383 43 dengue dengue NN cord-273505-pcsw3vmx 383 44 / / SYM cord-273505-pcsw3vmx 383 45 zika zika NNP cord-273505-pcsw3vmx 383 46 virus virus NN cord-273505-pcsw3vmx 383 47 pathogenicity pathogenicity NN cord-273505-pcsw3vmx 383 48 by by IN cord-273505-pcsw3vmx 383 49 antibody antibody NN cord-273505-pcsw3vmx 383 50 - - HYPH cord-273505-pcsw3vmx 383 51 dependent dependent JJ cord-273505-pcsw3vmx 383 52 enhancement enhancement NN cord-273505-pcsw3vmx 383 53 and and CC cord-273505-pcsw3vmx 383 54 strategies strategy NNS cord-273505-pcsw3vmx 383 55 to to TO cord-273505-pcsw3vmx 383 56 protect protect VB cord-273505-pcsw3vmx 383 57 against against IN cord-273505-pcsw3vmx 383 58 enhancement enhancement NN cord-273505-pcsw3vmx 383 59 in in IN cord-273505-pcsw3vmx 383 60 zika zika NNP cord-273505-pcsw3vmx 383 61 virus virus NN cord-273505-pcsw3vmx 383 62 infection infection NN cord-273505-pcsw3vmx 383 63 Ross Ross NNP cord-273505-pcsw3vmx 383 64 River River NNP cord-273505-pcsw3vmx 383 65 virus virus NN cord-273505-pcsw3vmx 383 66 : : : cord-273505-pcsw3vmx 383 67 molecular molecular JJ cord-273505-pcsw3vmx 383 68 and and CC cord-273505-pcsw3vmx 383 69 cellular cellular JJ cord-273505-pcsw3vmx 383 70 aspects aspect NNS cord-273505-pcsw3vmx 383 71 of of IN cord-273505-pcsw3vmx 383 72 disease disease NN cord-273505-pcsw3vmx 383 73 pathogenesis pathogenesis NN cord-273505-pcsw3vmx 383 74 Fc Fc NNP cord-273505-pcsw3vmx 383 75 receptors receptor NNS cord-273505-pcsw3vmx 383 76 in in IN cord-273505-pcsw3vmx 383 77 antibody antibody NN cord-273505-pcsw3vmx 383 78 - - HYPH cord-273505-pcsw3vmx 383 79 dependent dependent JJ cord-273505-pcsw3vmx 383 80 enhancement enhancement NN cord-273505-pcsw3vmx 383 81 of of IN cord-273505-pcsw3vmx 383 82 viral viral JJ cord-273505-pcsw3vmx 383 83 infections infection NNS cord-273505-pcsw3vmx 383 84 Antibody Antibody NNP cord-273505-pcsw3vmx 383 85 responses response NNS cord-273505-pcsw3vmx 383 86 against against IN cord-273505-pcsw3vmx 383 87 SARS SARS NNP cord-273505-pcsw3vmx 383 88 coronavirus coronavirus NN cord-273505-pcsw3vmx 383 89 are be VBP cord-273505-pcsw3vmx 383 90 correlated correlate VBN cord-273505-pcsw3vmx 383 91 with with IN cord-273505-pcsw3vmx 383 92 disease disease NN cord-273505-pcsw3vmx 383 93 outcome outcome NN cord-273505-pcsw3vmx 383 94 of of IN cord-273505-pcsw3vmx 383 95 infected infected JJ cord-273505-pcsw3vmx 383 96 individuals individual NNS cord-273505-pcsw3vmx 383 97 Mechanism Mechanism NNP cord-273505-pcsw3vmx 383 98 of of IN cord-273505-pcsw3vmx 383 99 antibody antibody NN cord-273505-pcsw3vmx 383 100 - - HYPH cord-273505-pcsw3vmx 383 101 dependent dependent JJ cord-273505-pcsw3vmx 383 102 enhancement enhancement NN cord-273505-pcsw3vmx 383 103 in in IN cord-273505-pcsw3vmx 383 104 severe severe JJ cord-273505-pcsw3vmx 383 105 acute acute JJ cord-273505-pcsw3vmx 383 106 respiratory respiratory JJ cord-273505-pcsw3vmx 383 107 syndrome syndrome NN cord-273505-pcsw3vmx 383 108 coronavirus coronavirus NN cord-273505-pcsw3vmx 383 109 infection infection NN cord-273505-pcsw3vmx 383 110 ( ( -LRB- cord-273505-pcsw3vmx 383 111 dissertation dissertation NN cord-273505-pcsw3vmx 383 112 ) ) -RRB- cord-273505-pcsw3vmx 383 113 . . . cord-273505-pcsw3vmx 384 1 The the DT cord-273505-pcsw3vmx 384 2 University University NNP cord-273505-pcsw3vmx 384 3 of of IN cord-273505-pcsw3vmx 384 4 Hong Hong NNP cord-273505-pcsw3vmx 384 5 Kong Kong NNP cord-273505-pcsw3vmx 384 6 Antibodydependent Antibodydependent NNP cord-273505-pcsw3vmx 384 7 infection infection NN cord-273505-pcsw3vmx 384 8 of of IN cord-273505-pcsw3vmx 384 9 human human JJ cord-273505-pcsw3vmx 384 10 macrophages macrophage NNS cord-273505-pcsw3vmx 384 11 by by IN cord-273505-pcsw3vmx 384 12 severe severe JJ cord-273505-pcsw3vmx 384 13 acute acute JJ cord-273505-pcsw3vmx 384 14 respiratory respiratory JJ cord-273505-pcsw3vmx 384 15 syndrome syndrome NN cord-273505-pcsw3vmx 384 16 coronavirus coronavirus NN cord-273505-pcsw3vmx 384 17 Molecular molecular JJ cord-273505-pcsw3vmx 384 18 mechanism mechanism NN cord-273505-pcsw3vmx 384 19 for for IN cord-273505-pcsw3vmx 384 20 antibody antibody NN cord-273505-pcsw3vmx 384 21 - - HYPH cord-273505-pcsw3vmx 384 22 dependent dependent JJ cord-273505-pcsw3vmx 384 23 enhancement enhancement NN cord-273505-pcsw3vmx 384 24 of of IN cord-273505-pcsw3vmx 384 25 coronavirus coronavirus NN cord-273505-pcsw3vmx 384 26 entry entry NN cord-273505-pcsw3vmx 384 27 Antibody antibody NN cord-273505-pcsw3vmx 384 28 - - HYPH cord-273505-pcsw3vmx 384 29 dependent dependent JJ cord-273505-pcsw3vmx 384 30 enhancement enhancement NN cord-273505-pcsw3vmx 384 31 of of IN cord-273505-pcsw3vmx 384 32 influenza influenza NN cord-273505-pcsw3vmx 384 33 disease disease NN cord-273505-pcsw3vmx 384 34 promoted promote VBN cord-273505-pcsw3vmx 384 35 by by IN cord-273505-pcsw3vmx 384 36 increase increase NN cord-273505-pcsw3vmx 384 37 in in IN cord-273505-pcsw3vmx 384 38 hemagglutinin hemagglutinin NN cord-273505-pcsw3vmx 384 39 stem stem NN cord-273505-pcsw3vmx 384 40 flexibility flexibility NN cord-273505-pcsw3vmx 384 41 and and CC cord-273505-pcsw3vmx 385 1 virus virus NN cord-273505-pcsw3vmx 385 2 fusion fusion NN cord-273505-pcsw3vmx 385 3 kinetics kinetics NNP cord-273505-pcsw3vmx 385 4 Vaccine Vaccine NNP cord-273505-pcsw3vmx 385 5 - - HYPH cord-273505-pcsw3vmx 385 6 induced induce VBN cord-273505-pcsw3vmx 385 7 anti anti NNP cord-273505-pcsw3vmx 385 8 - - JJ cord-273505-pcsw3vmx 385 9 HA2 ha2 JJ cord-273505-pcsw3vmx 385 10 antibodies antibody NNS cord-273505-pcsw3vmx 385 11 promote promote VBP cord-273505-pcsw3vmx 385 12 virus virus NN cord-273505-pcsw3vmx 385 13 fusion fusion NN cord-273505-pcsw3vmx 385 14 and and CC cord-273505-pcsw3vmx 385 15 enhance enhance VB cord-273505-pcsw3vmx 385 16 influenza influenza NN cord-273505-pcsw3vmx 385 17 virus virus NN cord-273505-pcsw3vmx 385 18 respiratory respiratory JJ cord-273505-pcsw3vmx 385 19 disease disease NN cord-273505-pcsw3vmx 385 20 Fc Fc NNP cord-273505-pcsw3vmx 385 21 - - HYPH cord-273505-pcsw3vmx 385 22 Mediated mediate VBN cord-273505-pcsw3vmx 385 23 antibody antibody NN cord-273505-pcsw3vmx 385 24 effector effector NN cord-273505-pcsw3vmx 385 25 functions function NNS cord-273505-pcsw3vmx 385 26 during during IN cord-273505-pcsw3vmx 385 27 respiratory respiratory JJ cord-273505-pcsw3vmx 385 28 syncytial syncytial JJ cord-273505-pcsw3vmx 385 29 virus virus NN cord-273505-pcsw3vmx 385 30 infection infection NN cord-273505-pcsw3vmx 385 31 and and CC cord-273505-pcsw3vmx 385 32 disease disease NN cord-273505-pcsw3vmx 385 33 Respiratory respiratory JJ cord-273505-pcsw3vmx 385 34 syncytial syncytial JJ cord-273505-pcsw3vmx 385 35 virus virus NN cord-273505-pcsw3vmx 385 36 infects infect VBZ cord-273505-pcsw3vmx 385 37 primary primary JJ cord-273505-pcsw3vmx 385 38 neonatal neonatal NN cord-273505-pcsw3vmx 385 39 and and CC cord-273505-pcsw3vmx 385 40 adult adult NN cord-273505-pcsw3vmx 385 41 natural natural JJ cord-273505-pcsw3vmx 385 42 killer killer NN cord-273505-pcsw3vmx 385 43 cells cell NNS cord-273505-pcsw3vmx 385 44 and and CC cord-273505-pcsw3vmx 385 45 affects affect VBZ cord-273505-pcsw3vmx 385 46 their -PRON- PRP$ cord-273505-pcsw3vmx 385 47 antiviral antiviral JJ cord-273505-pcsw3vmx 385 48 effector effector NN cord-273505-pcsw3vmx 385 49 function function NN cord-273505-pcsw3vmx 386 1 In in IN cord-273505-pcsw3vmx 386 2 vitro vitro FW cord-273505-pcsw3vmx 386 3 enhancement enhancement NN cord-273505-pcsw3vmx 386 4 of of IN cord-273505-pcsw3vmx 386 5 respiratory respiratory JJ cord-273505-pcsw3vmx 386 6 syncytial syncytial JJ cord-273505-pcsw3vmx 386 7 virus virus NN cord-273505-pcsw3vmx 386 8 infection infection NN cord-273505-pcsw3vmx 386 9 by by IN cord-273505-pcsw3vmx 386 10 maternal maternal JJ cord-273505-pcsw3vmx 386 11 antibodies antibody NNS cord-273505-pcsw3vmx 386 12 does do VBZ cord-273505-pcsw3vmx 386 13 not not RB cord-273505-pcsw3vmx 386 14 explain explain VB cord-273505-pcsw3vmx 386 15 disease disease NN cord-273505-pcsw3vmx 386 16 severity severity NN cord-273505-pcsw3vmx 386 17 in in IN cord-273505-pcsw3vmx 386 18 infants infant NNS cord-273505-pcsw3vmx 387 1 The the DT cord-273505-pcsw3vmx 387 2 potential potential JJ cord-273505-pcsw3vmx 387 3 danger danger NN cord-273505-pcsw3vmx 387 4 of of IN cord-273505-pcsw3vmx 387 5 suboptimal suboptimal JJ cord-273505-pcsw3vmx 387 6 antibody antibody NN cord-273505-pcsw3vmx 387 7 responses response NNS cord-273505-pcsw3vmx 387 8 in in IN cord-273505-pcsw3vmx 387 9 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 387 10 Viral Viral NNP cord-273505-pcsw3vmx 387 11 - - HYPH cord-273505-pcsw3vmx 387 12 induced induce VBN cord-273505-pcsw3vmx 387 13 enhanced enhanced JJ cord-273505-pcsw3vmx 387 14 disease disease NN cord-273505-pcsw3vmx 387 15 illness illness NN cord-273505-pcsw3vmx 388 1 Understanding understand VBG cord-273505-pcsw3vmx 388 2 SARS SARS NNP cord-273505-pcsw3vmx 388 3 - - HYPH cord-273505-pcsw3vmx 388 4 CoV-2-mediated cov-2-mediate VBN cord-273505-pcsw3vmx 388 5 inflammatory inflammatory JJ cord-273505-pcsw3vmx 388 6 responses response NNS cord-273505-pcsw3vmx 388 7 : : : cord-273505-pcsw3vmx 388 8 from from IN cord-273505-pcsw3vmx 388 9 mechanisms mechanism NNS cord-273505-pcsw3vmx 388 10 to to IN cord-273505-pcsw3vmx 388 11 potential potential JJ cord-273505-pcsw3vmx 388 12 therapeutic therapeutic JJ cord-273505-pcsw3vmx 388 13 tools tool NNS cord-273505-pcsw3vmx 388 14 Impact impact NN cord-273505-pcsw3vmx 388 15 of of IN cord-273505-pcsw3vmx 388 16 immune immune JJ cord-273505-pcsw3vmx 388 17 enhancement enhancement NN cord-273505-pcsw3vmx 388 18 on on IN cord-273505-pcsw3vmx 388 19 Covid-19 covid-19 JJ cord-273505-pcsw3vmx 388 20 polyclonal polyclonal JJ cord-273505-pcsw3vmx 388 21 hyperimmune hyperimmune NNP cord-273505-pcsw3vmx 388 22 globulin globulin NNP cord-273505-pcsw3vmx 388 23 therapy therapy NN cord-273505-pcsw3vmx 388 24 and and CC cord-273505-pcsw3vmx 388 25 vaccine vaccine NN cord-273505-pcsw3vmx 388 26 development development NN cord-273505-pcsw3vmx 388 27 Effective effective JJ cord-273505-pcsw3vmx 388 28 prophylaxis prophylaxis NN cord-273505-pcsw3vmx 388 29 of of IN cord-273505-pcsw3vmx 388 30 influenza influenza NN cord-273505-pcsw3vmx 388 31 A a DT cord-273505-pcsw3vmx 388 32 virus virus NN cord-273505-pcsw3vmx 388 33 pneumonia pneumonia NN cord-273505-pcsw3vmx 388 34 in in IN cord-273505-pcsw3vmx 388 35 mice mouse NNS cord-273505-pcsw3vmx 388 36 by by IN cord-273505-pcsw3vmx 388 37 topical topical JJ cord-273505-pcsw3vmx 388 38 passive passive JJ cord-273505-pcsw3vmx 388 39 immunotherapy immunotherapy NN cord-273505-pcsw3vmx 388 40 with with IN cord-273505-pcsw3vmx 388 41 polyvalent polyvalent JJ cord-273505-pcsw3vmx 388 42 human human JJ cord-273505-pcsw3vmx 388 43 immunoglobulins immunoglobulin NNS cord-273505-pcsw3vmx 388 44 or or CC cord-273505-pcsw3vmx 389 1 F(ab')2 f(ab')2 CD cord-273505-pcsw3vmx 389 2 fragments fragment NNS cord-273505-pcsw3vmx 390 1 Intravenous intravenous JJ cord-273505-pcsw3vmx 390 2 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 390 3 protects protect VBZ cord-273505-pcsw3vmx 390 4 against against IN cord-273505-pcsw3vmx 390 5 severe severe JJ cord-273505-pcsw3vmx 390 6 pandemic pandemic NN cord-273505-pcsw3vmx 390 7 influenza influenza NN cord-273505-pcsw3vmx 390 8 infection infection NN cord-273505-pcsw3vmx 391 1 Topically topically RB cord-273505-pcsw3vmx 391 2 administered administer VBN cord-273505-pcsw3vmx 391 3 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 391 4 reduces reduce VBZ cord-273505-pcsw3vmx 391 5 pulmonary pulmonary JJ cord-273505-pcsw3vmx 391 6 respiratory respiratory JJ cord-273505-pcsw3vmx 391 7 syncytial syncytial JJ cord-273505-pcsw3vmx 391 8 virus virus NN cord-273505-pcsw3vmx 391 9 shedding shed VBG cord-273505-pcsw3vmx 391 10 in in IN cord-273505-pcsw3vmx 391 11 owl owl NN cord-273505-pcsw3vmx 391 12 monkeys monkeys NNP cord-273505-pcsw3vmx 391 13 Studies Studies NNPS cord-273505-pcsw3vmx 391 14 of of IN cord-273505-pcsw3vmx 391 15 passive passive JJ cord-273505-pcsw3vmx 391 16 immunotherapy immunotherapy NN cord-273505-pcsw3vmx 391 17 for for IN cord-273505-pcsw3vmx 391 18 infections infection NNS cord-273505-pcsw3vmx 391 19 of of IN cord-273505-pcsw3vmx 391 20 respiratory respiratory JJ cord-273505-pcsw3vmx 391 21 syncytial syncytial JJ cord-273505-pcsw3vmx 391 22 virus virus NN cord-273505-pcsw3vmx 391 23 in in IN cord-273505-pcsw3vmx 391 24 the the DT cord-273505-pcsw3vmx 391 25 respiratory respiratory JJ cord-273505-pcsw3vmx 391 26 tract tract NN cord-273505-pcsw3vmx 391 27 of of IN cord-273505-pcsw3vmx 391 28 a a DT cord-273505-pcsw3vmx 391 29 primate primate JJ cord-273505-pcsw3vmx 391 30 model model NN cord-273505-pcsw3vmx 391 31 Effectiveness Effectiveness NNP cord-273505-pcsw3vmx 391 32 of of IN cord-273505-pcsw3vmx 391 33 topically topically RB cord-273505-pcsw3vmx 391 34 administered administer VBN cord-273505-pcsw3vmx 391 35 neutralizing neutralize VBG cord-273505-pcsw3vmx 391 36 antibodies antibody NNS cord-273505-pcsw3vmx 391 37 in in IN cord-273505-pcsw3vmx 391 38 experimental experimental JJ cord-273505-pcsw3vmx 391 39 immunotherapy immunotherapy NN cord-273505-pcsw3vmx 391 40 of of IN cord-273505-pcsw3vmx 391 41 respiratory respiratory JJ cord-273505-pcsw3vmx 391 42 syncytial syncytial JJ cord-273505-pcsw3vmx 391 43 virus virus NN cord-273505-pcsw3vmx 391 44 infection infection NN cord-273505-pcsw3vmx 391 45 in in IN cord-273505-pcsw3vmx 391 46 cotton cotton NN cord-273505-pcsw3vmx 391 47 rats rat NNS cord-273505-pcsw3vmx 392 1 Effect effect NN cord-273505-pcsw3vmx 392 2 of of IN cord-273505-pcsw3vmx 392 3 regular regular JJ cord-273505-pcsw3vmx 392 4 intravenous intravenous JJ cord-273505-pcsw3vmx 392 5 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 392 6 therapy therapy NN cord-273505-pcsw3vmx 392 7 on on IN cord-273505-pcsw3vmx 392 8 prognosis prognosis NN cord-273505-pcsw3vmx 392 9 of of IN cord-273505-pcsw3vmx 392 10 severe severe JJ cord-273505-pcsw3vmx 392 11 pneumonia pneumonia NN cord-273505-pcsw3vmx 392 12 in in IN cord-273505-pcsw3vmx 392 13 patients patient NNS cord-273505-pcsw3vmx 392 14 with with IN cord-273505-pcsw3vmx 392 15 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 392 16 Clinical clinical JJ cord-273505-pcsw3vmx 392 17 features feature NNS cord-273505-pcsw3vmx 392 18 and and CC cord-273505-pcsw3vmx 392 19 progression progression NN cord-273505-pcsw3vmx 392 20 of of IN cord-273505-pcsw3vmx 392 21 acute acute JJ cord-273505-pcsw3vmx 392 22 respiratory respiratory JJ cord-273505-pcsw3vmx 392 23 distress distress NN cord-273505-pcsw3vmx 392 24 syndrome syndrome NN cord-273505-pcsw3vmx 392 25 in in IN cord-273505-pcsw3vmx 392 26 coronavirus coronavirus NN cord-273505-pcsw3vmx 392 27 disease disease NN cord-273505-pcsw3vmx 392 28 2019 2019 CD cord-273505-pcsw3vmx 392 29 . . . cord-273505-pcsw3vmx 393 1 medRxiv medRxiv NNP cord-273505-pcsw3vmx 393 2 Shortterm shortterm JJ cord-273505-pcsw3vmx 393 3 moderate moderate JJ cord-273505-pcsw3vmx 393 4 - - HYPH cord-273505-pcsw3vmx 393 5 dose dose NN cord-273505-pcsw3vmx 393 6 corticosteroid corticosteroid NN cord-273505-pcsw3vmx 393 7 plus plus CC cord-273505-pcsw3vmx 393 8 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 393 9 effectively effectively RB cord-273505-pcsw3vmx 393 10 reverses reverse VBZ cord-273505-pcsw3vmx 393 11 COVID-19 COVID-19 JJR cord-273505-pcsw3vmx 393 12 patients patient NNS cord-273505-pcsw3vmx 393 13 who who WP cord-273505-pcsw3vmx 393 14 have have VBP cord-273505-pcsw3vmx 393 15 failed fail VBN cord-273505-pcsw3vmx 393 16 low low JJ cord-273505-pcsw3vmx 393 17 - - HYPH cord-273505-pcsw3vmx 393 18 dose dose NN cord-273505-pcsw3vmx 393 19 therapy therapy NN cord-273505-pcsw3vmx 393 20 Clinical clinical JJ cord-273505-pcsw3vmx 393 21 manifestations manifestation NNS cord-273505-pcsw3vmx 393 22 , , , cord-273505-pcsw3vmx 393 23 laboratory laboratory NN cord-273505-pcsw3vmx 393 24 findings finding NNS cord-273505-pcsw3vmx 393 25 , , , cord-273505-pcsw3vmx 393 26 and and CC cord-273505-pcsw3vmx 393 27 treatment treatment NN cord-273505-pcsw3vmx 393 28 outcomes outcome NNS cord-273505-pcsw3vmx 393 29 of of IN cord-273505-pcsw3vmx 393 30 SARS SARS NNP cord-273505-pcsw3vmx 393 31 patients patient NNS cord-273505-pcsw3vmx 393 32 Pentaglobin Pentaglobin NNP cord-273505-pcsw3vmx 393 33 in in IN cord-273505-pcsw3vmx 393 34 steroid steroid JJ cord-273505-pcsw3vmx 393 35 - - HYPH cord-273505-pcsw3vmx 393 36 resistant resistant JJ cord-273505-pcsw3vmx 393 37 severe severe JJ cord-273505-pcsw3vmx 393 38 acute acute JJ cord-273505-pcsw3vmx 393 39 respiratory respiratory JJ cord-273505-pcsw3vmx 393 40 syndrome syndrome NN cord-273505-pcsw3vmx 393 41 Clinical clinical JJ cord-273505-pcsw3vmx 393 42 and and CC cord-273505-pcsw3vmx 393 43 laboratory laboratory NN cord-273505-pcsw3vmx 393 44 findings finding NNS cord-273505-pcsw3vmx 393 45 of of IN cord-273505-pcsw3vmx 393 46 the the DT cord-273505-pcsw3vmx 393 47 first first JJ cord-273505-pcsw3vmx 393 48 imported import VBN cord-273505-pcsw3vmx 393 49 case case NN cord-273505-pcsw3vmx 393 50 of of IN cord-273505-pcsw3vmx 393 51 Middle Middle NNP cord-273505-pcsw3vmx 393 52 East East NNP cord-273505-pcsw3vmx 393 53 respiratory respiratory JJ cord-273505-pcsw3vmx 393 54 syndrome syndrome NN cord-273505-pcsw3vmx 393 55 coronavirus coronavirus NN cord-273505-pcsw3vmx 393 56 to to IN cord-273505-pcsw3vmx 393 57 the the DT cord-273505-pcsw3vmx 393 58 United United NNP cord-273505-pcsw3vmx 393 59 States States NNP cord-273505-pcsw3vmx 393 60 Hyperimmune Hyperimmune NNP cord-273505-pcsw3vmx 393 61 IV IV NNP cord-273505-pcsw3vmx 393 62 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 393 63 treatment treatment NN cord-273505-pcsw3vmx 393 64 : : : cord-273505-pcsw3vmx 393 65 a a DT cord-273505-pcsw3vmx 393 66 multicenter multicenter JJ cord-273505-pcsw3vmx 393 67 double double JJ cord-273505-pcsw3vmx 393 68 - - HYPH cord-273505-pcsw3vmx 393 69 blind blind JJ cord-273505-pcsw3vmx 393 70 randomized randomize VBN cord-273505-pcsw3vmx 393 71 controlled control VBN cord-273505-pcsw3vmx 393 72 trial trial NN cord-273505-pcsw3vmx 393 73 for for IN cord-273505-pcsw3vmx 393 74 patients patient NNS cord-273505-pcsw3vmx 393 75 with with IN cord-273505-pcsw3vmx 393 76 severe severe JJ cord-273505-pcsw3vmx 393 77 2009 2009 CD cord-273505-pcsw3vmx 393 78 influenza influenza NN cord-273505-pcsw3vmx 393 79 A(H1N1 a(h1n1 NN cord-273505-pcsw3vmx 393 80 ) ) -RRB- cord-273505-pcsw3vmx 393 81 infection infection NN cord-273505-pcsw3vmx 393 82 High high JJ cord-273505-pcsw3vmx 393 83 - - HYPH cord-273505-pcsw3vmx 393 84 dose dose NN cord-273505-pcsw3vmx 393 85 intravenous intravenous JJ cord-273505-pcsw3vmx 393 86 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 393 87 for for IN cord-273505-pcsw3vmx 393 88 children child NNS cord-273505-pcsw3vmx 393 89 with with IN cord-273505-pcsw3vmx 393 90 severe severe JJ cord-273505-pcsw3vmx 393 91 H1N1 H1N1 NNP cord-273505-pcsw3vmx 393 92 influenza influenza NN cord-273505-pcsw3vmx 393 93 infection infection NN cord-273505-pcsw3vmx 393 94 Risk risk NN cord-273505-pcsw3vmx 393 95 factors factor NNS cord-273505-pcsw3vmx 393 96 and and CC cord-273505-pcsw3vmx 393 97 containment containment NN cord-273505-pcsw3vmx 393 98 of of IN cord-273505-pcsw3vmx 393 99 respiratory respiratory JJ cord-273505-pcsw3vmx 393 100 syncytial syncytial JJ cord-273505-pcsw3vmx 393 101 virus virus NN cord-273505-pcsw3vmx 393 102 outbreak outbreak NN cord-273505-pcsw3vmx 393 103 in in IN cord-273505-pcsw3vmx 393 104 a a DT cord-273505-pcsw3vmx 393 105 hematology hematology NN cord-273505-pcsw3vmx 393 106 and and CC cord-273505-pcsw3vmx 393 107 transplant transplant NN cord-273505-pcsw3vmx 393 108 unit unit NN cord-273505-pcsw3vmx 393 109 Treatment treatment NN cord-273505-pcsw3vmx 393 110 stratification stratification NN cord-273505-pcsw3vmx 393 111 of of IN cord-273505-pcsw3vmx 393 112 respiratory respiratory JJ cord-273505-pcsw3vmx 393 113 syncytial syncytial JJ cord-273505-pcsw3vmx 393 114 virus virus NN cord-273505-pcsw3vmx 393 115 infection infection NN cord-273505-pcsw3vmx 393 116 in in IN cord-273505-pcsw3vmx 393 117 allogeneic allogeneic NN cord-273505-pcsw3vmx 393 118 stem stem NN cord-273505-pcsw3vmx 393 119 cell cell NN cord-273505-pcsw3vmx 393 120 transplantation transplantation NN cord-273505-pcsw3vmx 393 121 Respiratory respiratory JJ cord-273505-pcsw3vmx 393 122 syncytial syncytial JJ cord-273505-pcsw3vmx 393 123 virus virus NN cord-273505-pcsw3vmx 393 124 upper upper JJ cord-273505-pcsw3vmx 393 125 respiratory respiratory JJ cord-273505-pcsw3vmx 393 126 tract tract NN cord-273505-pcsw3vmx 393 127 illnesses illness NNS cord-273505-pcsw3vmx 393 128 in in IN cord-273505-pcsw3vmx 393 129 adult adult NN cord-273505-pcsw3vmx 393 130 blood blood NN cord-273505-pcsw3vmx 393 131 and and CC cord-273505-pcsw3vmx 393 132 marrow marrow NN cord-273505-pcsw3vmx 393 133 transplant transplant NN cord-273505-pcsw3vmx 393 134 recipients recipient NNS cord-273505-pcsw3vmx 393 135 : : : cord-273505-pcsw3vmx 393 136 combination combination NN cord-273505-pcsw3vmx 393 137 therapy therapy NN cord-273505-pcsw3vmx 393 138 with with IN cord-273505-pcsw3vmx 393 139 aerosolized aerosolized JJ cord-273505-pcsw3vmx 393 140 ribavirin ribavirin NN cord-273505-pcsw3vmx 393 141 and and CC cord-273505-pcsw3vmx 393 142 intravenous intravenous JJ cord-273505-pcsw3vmx 393 143 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 393 144 Treatment treatment NN cord-273505-pcsw3vmx 393 145 of of IN cord-273505-pcsw3vmx 393 146 severe severe JJ cord-273505-pcsw3vmx 393 147 acute acute JJ cord-273505-pcsw3vmx 393 148 respiratory respiratory JJ cord-273505-pcsw3vmx 393 149 syndrome syndrome NN cord-273505-pcsw3vmx 393 150 SARS SARS NNP cord-273505-pcsw3vmx 393 151 : : : cord-273505-pcsw3vmx 393 152 systematic systematic JJ cord-273505-pcsw3vmx 393 153 review review NN cord-273505-pcsw3vmx 393 154 of of IN cord-273505-pcsw3vmx 393 155 treatment treatment NN cord-273505-pcsw3vmx 393 156 effects effect NNS cord-273505-pcsw3vmx 393 157 Effects effect NNS cord-273505-pcsw3vmx 393 158 of of IN cord-273505-pcsw3vmx 393 159 pentoxifyllin pentoxifyllin NN cord-273505-pcsw3vmx 393 160 and and CC cord-273505-pcsw3vmx 393 161 pentaglobinO pentaglobinO NNP cord-273505-pcsw3vmx 393 162 on on IN cord-273505-pcsw3vmx 393 163 TNF TNF NNP cord-273505-pcsw3vmx 393 164 and and CC cord-273505-pcsw3vmx 393 165 IL-6 IL-6 NNP cord-273505-pcsw3vmx 393 166 production production NN cord-273505-pcsw3vmx 393 167 in in IN cord-273505-pcsw3vmx 393 168 septic septic JJ cord-273505-pcsw3vmx 393 169 patients patient NNS cord-273505-pcsw3vmx 394 1 Clinical clinical JJ cord-273505-pcsw3vmx 394 2 course course NN cord-273505-pcsw3vmx 394 3 and and CC cord-273505-pcsw3vmx 394 4 outcomes outcome NNS cord-273505-pcsw3vmx 394 5 of of IN cord-273505-pcsw3vmx 394 6 critically critically RB cord-273505-pcsw3vmx 394 7 ill ill JJ cord-273505-pcsw3vmx 394 8 patients patient NNS cord-273505-pcsw3vmx 394 9 with with IN cord-273505-pcsw3vmx 394 10 Middle Middle NNP cord-273505-pcsw3vmx 394 11 East East NNP cord-273505-pcsw3vmx 394 12 respiratory respiratory JJ cord-273505-pcsw3vmx 394 13 syndrome syndrome NN cord-273505-pcsw3vmx 394 14 coronavirus coronavirus NN cord-273505-pcsw3vmx 394 15 infection infection NN cord-273505-pcsw3vmx 395 1 The the DT cord-273505-pcsw3vmx 395 2 cytokine cytokine NN cord-273505-pcsw3vmx 395 3 storm storm NN cord-273505-pcsw3vmx 395 4 of of IN cord-273505-pcsw3vmx 395 5 severe severe JJ cord-273505-pcsw3vmx 395 6 influenza influenza NN cord-273505-pcsw3vmx 395 7 and and CC cord-273505-pcsw3vmx 395 8 development development NN cord-273505-pcsw3vmx 395 9 of of IN cord-273505-pcsw3vmx 395 10 immunomodulatory immunomodulatory JJ cord-273505-pcsw3vmx 395 11 therapy therapy NN cord-273505-pcsw3vmx 395 12 Respiratory respiratory JJ cord-273505-pcsw3vmx 395 13 syncytial syncytial JJ cord-273505-pcsw3vmx 395 14 virus virus NN cord-273505-pcsw3vmx 395 15 : : : cord-273505-pcsw3vmx 395 16 prospects prospect NNS cord-273505-pcsw3vmx 395 17 for for IN cord-273505-pcsw3vmx 395 18 new new JJ cord-273505-pcsw3vmx 395 19 and and CC cord-273505-pcsw3vmx 395 20 emerging emerge VBG cord-273505-pcsw3vmx 395 21 therapeutics therapeutic NNS cord-273505-pcsw3vmx 395 22 Management Management NNP cord-273505-pcsw3vmx 395 23 of of IN cord-273505-pcsw3vmx 395 24 RSV RSV NNP cord-273505-pcsw3vmx 395 25 infections infection NNS cord-273505-pcsw3vmx 395 26 in in IN cord-273505-pcsw3vmx 395 27 adult adult NN cord-273505-pcsw3vmx 395 28 recipients recipient NNS cord-273505-pcsw3vmx 395 29 of of IN cord-273505-pcsw3vmx 395 30 hematopoietic hematopoietic JJ cord-273505-pcsw3vmx 395 31 stem stem NN cord-273505-pcsw3vmx 395 32 cell cell NN cord-273505-pcsw3vmx 395 33 transplantation transplantation NN cord-273505-pcsw3vmx 395 34 Impact impact NN cord-273505-pcsw3vmx 395 35 of of IN cord-273505-pcsw3vmx 395 36 aerosolized aerosolize VBN cord-273505-pcsw3vmx 395 37 ribavirin ribavirin NN cord-273505-pcsw3vmx 395 38 on on IN cord-273505-pcsw3vmx 395 39 mortality mortality NN cord-273505-pcsw3vmx 395 40 in in IN cord-273505-pcsw3vmx 395 41 280 280 CD cord-273505-pcsw3vmx 395 42 allogeneic allogeneic IN cord-273505-pcsw3vmx 395 43 haematopoietic haematopoietic JJ cord-273505-pcsw3vmx 395 44 stem stem NN cord-273505-pcsw3vmx 395 45 cell cell NN cord-273505-pcsw3vmx 395 46 transplant transplant NN cord-273505-pcsw3vmx 395 47 recipients recipient NNS cord-273505-pcsw3vmx 395 48 with with IN cord-273505-pcsw3vmx 395 49 respiratory respiratory JJ cord-273505-pcsw3vmx 395 50 syncytial syncytial JJ cord-273505-pcsw3vmx 395 51 virus virus NN cord-273505-pcsw3vmx 395 52 infections infection NNS cord-273505-pcsw3vmx 395 53 ECIL-4 ECIL-4 NNP cord-273505-pcsw3vmx 395 54 ) ) -RRB- cord-273505-pcsw3vmx 395 55 : : : cord-273505-pcsw3vmx 395 56 guidelines guideline NNS cord-273505-pcsw3vmx 395 57 for for IN cord-273505-pcsw3vmx 395 58 diagnosis diagnosis NN cord-273505-pcsw3vmx 395 59 and and CC cord-273505-pcsw3vmx 395 60 treatment treatment NN cord-273505-pcsw3vmx 395 61 of of IN cord-273505-pcsw3vmx 395 62 human human JJ cord-273505-pcsw3vmx 395 63 respiratory respiratory JJ cord-273505-pcsw3vmx 395 64 syncytial syncytial JJ cord-273505-pcsw3vmx 395 65 virus virus NN cord-273505-pcsw3vmx 395 66 , , , cord-273505-pcsw3vmx 395 67 parainfluenza parainfluenza NNP cord-273505-pcsw3vmx 395 68 virus virus NNP cord-273505-pcsw3vmx 395 69 , , , cord-273505-pcsw3vmx 395 70 metapneumovirus metapneumovirus NNP cord-273505-pcsw3vmx 395 71 , , , cord-273505-pcsw3vmx 395 72 rhinovirus rhinovirus NN cord-273505-pcsw3vmx 395 73 , , , cord-273505-pcsw3vmx 395 74 and and CC cord-273505-pcsw3vmx 395 75 coronavirus coronavirus NN cord-273505-pcsw3vmx 395 76 Effective effective JJ cord-273505-pcsw3vmx 395 77 use use NN cord-273505-pcsw3vmx 395 78 of of IN cord-273505-pcsw3vmx 395 79 oral oral JJ cord-273505-pcsw3vmx 395 80 ribavirin ribavirin NN cord-273505-pcsw3vmx 395 81 for for IN cord-273505-pcsw3vmx 395 82 respiratory respiratory JJ cord-273505-pcsw3vmx 395 83 syncytial syncytial JJ cord-273505-pcsw3vmx 395 84 viral viral JJ cord-273505-pcsw3vmx 395 85 infections infection NNS cord-273505-pcsw3vmx 395 86 in in IN cord-273505-pcsw3vmx 395 87 allogeneic allogeneic JJ cord-273505-pcsw3vmx 395 88 haematopoietic haematopoietic JJ cord-273505-pcsw3vmx 395 89 stem stem NN cord-273505-pcsw3vmx 395 90 cell cell NN cord-273505-pcsw3vmx 395 91 transplant transplant NN cord-273505-pcsw3vmx 395 92 recipients recipient NNS cord-273505-pcsw3vmx 395 93 Community Community NNP cord-273505-pcsw3vmx 395 94 acquired acquire VBD cord-273505-pcsw3vmx 395 95 respiratory respiratory JJ cord-273505-pcsw3vmx 395 96 virus virus NN cord-273505-pcsw3vmx 395 97 infections infection NNS cord-273505-pcsw3vmx 395 98 in in IN cord-273505-pcsw3vmx 395 99 cancer cancer NN cord-273505-pcsw3vmx 395 100 patients patient NNS cord-273505-pcsw3vmx 395 101 - - : cord-273505-pcsw3vmx 395 102 Guideline Guideline NNP cord-273505-pcsw3vmx 395 103 on on IN cord-273505-pcsw3vmx 395 104 diagnosis diagnosis NN cord-273505-pcsw3vmx 395 105 and and CC cord-273505-pcsw3vmx 395 106 management management NN cord-273505-pcsw3vmx 395 107 by by IN cord-273505-pcsw3vmx 395 108 the the DT cord-273505-pcsw3vmx 395 109 Infectious Infectious NNP cord-273505-pcsw3vmx 395 110 Diseases Diseases NNPS cord-273505-pcsw3vmx 395 111 Working Working NNP cord-273505-pcsw3vmx 395 112 Party Party NNP cord-273505-pcsw3vmx 395 113 of of IN cord-273505-pcsw3vmx 395 114 the the DT cord-273505-pcsw3vmx 395 115 German German NNP cord-273505-pcsw3vmx 395 116 Society Society NNP cord-273505-pcsw3vmx 395 117 for for IN cord-273505-pcsw3vmx 395 118 haematology haematology NNP cord-273505-pcsw3vmx 395 119 and and CC cord-273505-pcsw3vmx 395 120 Medical Medical NNP cord-273505-pcsw3vmx 395 121 Oncology Oncology NNP cord-273505-pcsw3vmx 395 122 Adverse adverse JJ cord-273505-pcsw3vmx 395 123 effects effect NNS cord-273505-pcsw3vmx 395 124 of of IN cord-273505-pcsw3vmx 395 125 immunoglobulin immunoglobulin NN cord-273505-pcsw3vmx 395 126 therapy therapy NN cord-273505-pcsw3vmx 395 127 COVID-19 COVID-19 NNP cord-273505-pcsw3vmx 395 128 and and CC cord-273505-pcsw3vmx 395 129 thrombotic thrombotic JJ cord-273505-pcsw3vmx 395 130 or or CC cord-273505-pcsw3vmx 395 131 thromboembolic thromboembolic JJ cord-273505-pcsw3vmx 395 132 disease disease NN cord-273505-pcsw3vmx 395 133 : : : cord-273505-pcsw3vmx 395 134 implications implication NNS cord-273505-pcsw3vmx 395 135 for for IN cord-273505-pcsw3vmx 395 136 prevention prevention NN cord-273505-pcsw3vmx 395 137 , , , cord-273505-pcsw3vmx 395 138 antithrombotic antithrombotic JJ cord-273505-pcsw3vmx 395 139 therapy therapy NN cord-273505-pcsw3vmx 395 140 , , , cord-273505-pcsw3vmx 395 141 and and CC cord-273505-pcsw3vmx 395 142 follow follow NN cord-273505-pcsw3vmx 395 143 - - HYPH cord-273505-pcsw3vmx 395 144 up up NN cord-273505-pcsw3vmx 396 1 The the DT cord-273505-pcsw3vmx 396 2 authors author NNS cord-273505-pcsw3vmx 396 3 declare declare VBP cord-273505-pcsw3vmx 396 4 that that IN cord-273505-pcsw3vmx 396 5 the the DT cord-273505-pcsw3vmx 396 6 research research NN cord-273505-pcsw3vmx 396 7 was be VBD cord-273505-pcsw3vmx 396 8 conducted conduct VBN cord-273505-pcsw3vmx 396 9 in in IN cord-273505-pcsw3vmx 396 10 the the DT cord-273505-pcsw3vmx 396 11 absence absence NN cord-273505-pcsw3vmx 396 12 of of IN cord-273505-pcsw3vmx 396 13 any any DT cord-273505-pcsw3vmx 396 14 commercial commercial JJ cord-273505-pcsw3vmx 396 15 or or CC cord-273505-pcsw3vmx 396 16 financial financial JJ cord-273505-pcsw3vmx 396 17 relationships relationship NNS cord-273505-pcsw3vmx 396 18 that that WDT cord-273505-pcsw3vmx 396 19 could could MD cord-273505-pcsw3vmx 396 20 be be VB cord-273505-pcsw3vmx 396 21 construed construe VBN cord-273505-pcsw3vmx 396 22 as as IN cord-273505-pcsw3vmx 396 23 a a DT cord-273505-pcsw3vmx 396 24 potential potential JJ cord-273505-pcsw3vmx 396 25 conflict conflict NN cord-273505-pcsw3vmx 396 26 of of IN cord-273505-pcsw3vmx 396 27 interest interest NN cord-273505-pcsw3vmx 396 28 . . . cord-273505-pcsw3vmx 397 1 Copyright copyright NN cord-273505-pcsw3vmx 397 2 © © NNP cord-273505-pcsw3vmx 397 3 2020 2020 CD cord-273505-pcsw3vmx 397 4 Liu Liu NNP cord-273505-pcsw3vmx 397 5 , , , cord-273505-pcsw3vmx 397 6 Cao Cao NNP cord-273505-pcsw3vmx 397 7 and and CC cord-273505-pcsw3vmx 397 8 Li Li NNP cord-273505-pcsw3vmx 397 9 . . . cord-273505-pcsw3vmx 398 1 This this DT cord-273505-pcsw3vmx 398 2 is be VBZ cord-273505-pcsw3vmx 398 3 an an DT cord-273505-pcsw3vmx 398 4 open open JJ cord-273505-pcsw3vmx 398 5 - - HYPH cord-273505-pcsw3vmx 398 6 access access NN cord-273505-pcsw3vmx 398 7 article article NN cord-273505-pcsw3vmx 398 8 distributed distribute VBN cord-273505-pcsw3vmx 398 9 under under IN cord-273505-pcsw3vmx 398 10 the the DT cord-273505-pcsw3vmx 398 11 terms term NNS cord-273505-pcsw3vmx 398 12 of of IN cord-273505-pcsw3vmx 398 13 the the DT cord-273505-pcsw3vmx 398 14 Creative Creative NNP cord-273505-pcsw3vmx 398 15 Commons Commons NNP cord-273505-pcsw3vmx 398 16 Attribution Attribution NNP cord-273505-pcsw3vmx 398 17 License License NNP cord-273505-pcsw3vmx 398 18 ( ( -LRB- cord-273505-pcsw3vmx 398 19 CC CC NNP cord-273505-pcsw3vmx 398 20 BY BY NNP cord-273505-pcsw3vmx 398 21 ) ) -RRB- cord-273505-pcsw3vmx 398 22 . . . cord-273505-pcsw3vmx 399 1 The the DT cord-273505-pcsw3vmx 399 2 use use NN cord-273505-pcsw3vmx 399 3 , , , cord-273505-pcsw3vmx 399 4 distribution distribution NN cord-273505-pcsw3vmx 399 5 or or CC cord-273505-pcsw3vmx 399 6 reproduction reproduction NN cord-273505-pcsw3vmx 399 7 in in IN cord-273505-pcsw3vmx 399 8 other other JJ cord-273505-pcsw3vmx 399 9 forums forum NNS cord-273505-pcsw3vmx 399 10 is be VBZ cord-273505-pcsw3vmx 399 11 permitted permit VBN cord-273505-pcsw3vmx 399 12 , , , cord-273505-pcsw3vmx 399 13 provided provide VBD cord-273505-pcsw3vmx 399 14 the the DT cord-273505-pcsw3vmx 399 15 original original JJ cord-273505-pcsw3vmx 399 16 author(s author(s NNP cord-273505-pcsw3vmx 399 17 ) ) -RRB- cord-273505-pcsw3vmx 399 18 and and CC cord-273505-pcsw3vmx 399 19 the the DT cord-273505-pcsw3vmx 399 20 copyright copyright NN cord-273505-pcsw3vmx 399 21 owner(s owner(s NNP cord-273505-pcsw3vmx 399 22 ) ) -RRB- cord-273505-pcsw3vmx 399 23 are be VBP cord-273505-pcsw3vmx 399 24 credited credit VBN cord-273505-pcsw3vmx 399 25 and and CC cord-273505-pcsw3vmx 399 26 that that IN cord-273505-pcsw3vmx 399 27 the the DT cord-273505-pcsw3vmx 399 28 original original JJ cord-273505-pcsw3vmx 399 29 publication publication NN cord-273505-pcsw3vmx 399 30 in in IN cord-273505-pcsw3vmx 399 31 this this DT cord-273505-pcsw3vmx 399 32 journal journal NN cord-273505-pcsw3vmx 399 33 is be VBZ cord-273505-pcsw3vmx 399 34 cited cite VBN cord-273505-pcsw3vmx 399 35 , , , cord-273505-pcsw3vmx 399 36 in in IN cord-273505-pcsw3vmx 399 37 accordance accordance NN cord-273505-pcsw3vmx 399 38 with with IN cord-273505-pcsw3vmx 399 39 accepted accepted JJ cord-273505-pcsw3vmx 399 40 academic academic JJ cord-273505-pcsw3vmx 399 41 practice practice NN cord-273505-pcsw3vmx 399 42 . . . cord-273505-pcsw3vmx 400 1 No no DT cord-273505-pcsw3vmx 400 2 use use NN cord-273505-pcsw3vmx 400 3 , , , cord-273505-pcsw3vmx 400 4 distribution distribution NN cord-273505-pcsw3vmx 400 5 or or CC cord-273505-pcsw3vmx 400 6 reproduction reproduction NN cord-273505-pcsw3vmx 400 7 is be VBZ cord-273505-pcsw3vmx 400 8 permitted permit VBN cord-273505-pcsw3vmx 400 9 which which WDT cord-273505-pcsw3vmx 400 10 does do VBZ cord-273505-pcsw3vmx 400 11 not not RB cord-273505-pcsw3vmx 400 12 comply comply VB cord-273505-pcsw3vmx 400 13 with with IN cord-273505-pcsw3vmx 400 14 these these DT cord-273505-pcsw3vmx 400 15 terms term NNS cord-273505-pcsw3vmx 400 16 . . .