id sid tid token lemma pos cord-272015-1anph6qi 1 1 key key JJ cord-272015-1anph6qi 1 2 : : : cord-272015-1anph6qi 1 3 cord-272015 cord-272015 JJ cord-272015-1anph6qi 1 4 - - HYPH cord-272015-1anph6qi 1 5 1anph6qi 1anph6qi CD cord-272015-1anph6qi 1 6 authors author NNS cord-272015-1anph6qi 1 7 : : : cord-272015-1anph6qi 1 8 Dauby Dauby NNP cord-272015-1anph6qi 1 9 , , , cord-272015-1anph6qi 1 10 Nicolas Nicolas NNP cord-272015-1anph6qi 1 11 ; ; : cord-272015-1anph6qi 1 12 Bottieau Bottieau NNP cord-272015-1anph6qi 1 13 , , , cord-272015-1anph6qi 1 14 Emmanuel Emmanuel NNP cord-272015-1anph6qi 2 1 title title NN cord-272015-1anph6qi 2 2 : : : cord-272015-1anph6qi 2 3 The the DT cord-272015-1anph6qi 2 4 unfinished unfinished JJ cord-272015-1anph6qi 2 5 story story NN cord-272015-1anph6qi 2 6 of of IN cord-272015-1anph6qi 2 7 hydroxychloroquine hydroxychloroquine NNP cord-272015-1anph6qi 2 8 in in IN cord-272015-1anph6qi 2 9 COVID-19 COVID-19 NNP cord-272015-1anph6qi 2 10 : : : cord-272015-1anph6qi 2 11 the the DT cord-272015-1anph6qi 2 12 right right JJ cord-272015-1anph6qi 2 13 anti anti JJ cord-272015-1anph6qi 2 14 - - JJ cord-272015-1anph6qi 2 15 inflammatory inflammatory JJ cord-272015-1anph6qi 2 16 dose dose NN cord-272015-1anph6qi 2 17 at at IN cord-272015-1anph6qi 2 18 the the DT cord-272015-1anph6qi 2 19 right right JJ cord-272015-1anph6qi 2 20 moment moment NN cord-272015-1anph6qi 2 21 ? ? . cord-272015-1anph6qi 3 1 date date NN cord-272015-1anph6qi 3 2 : : : cord-272015-1anph6qi 3 3 2020 2020 CD cord-272015-1anph6qi 3 4 - - SYM cord-272015-1anph6qi 3 5 10 10 CD cord-272015-1anph6qi 3 6 - - SYM cord-272015-1anph6qi 3 7 17 17 CD cord-272015-1anph6qi 3 8 journal journal NN cord-272015-1anph6qi 3 9 : : : cord-272015-1anph6qi 4 1 Int Int NNP cord-272015-1anph6qi 4 2 J J NNP cord-272015-1anph6qi 4 3 Infect infect VB cord-272015-1anph6qi 4 4 Dis Dis NNP cord-272015-1anph6qi 4 5 DOI doi NN cord-272015-1anph6qi 4 6 : : : cord-272015-1anph6qi 4 7 10.1016/ 10.1016/ CD cord-272015-1anph6qi 5 1 j.ijid.2020.10.032 j.ijid.2020.10.032 NNP cord-272015-1anph6qi 5 2 sha sha XX cord-272015-1anph6qi 5 3 : : : cord-272015-1anph6qi 6 1 6b33212fc439d64a833e518385e4999e28ab3138 6b33212fc439d64a833e518385e4999e28ab3138 CD cord-272015-1anph6qi 6 2 doc_id doc_id CD cord-272015-1anph6qi 7 1 : : : cord-272015-1anph6qi 7 2 272015 272015 CD cord-272015-1anph6qi 7 3 cord_uid cord_uid NNS cord-272015-1anph6qi 7 4 : : : cord-272015-1anph6qi 8 1 1anph6qi 1anph6qi CD cord-272015-1anph6qi 9 1 nan nan NNP cord-272015-1anph6qi 9 2 Dear Dear NNP cord-272015-1anph6qi 9 3 Editor Editor NNP cord-272015-1anph6qi 9 4 , , , cord-272015-1anph6qi 9 5 Uncontrolled uncontrolled JJ cord-272015-1anph6qi 9 6 inflammation inflammation NN cord-272015-1anph6qi 9 7 , , , cord-272015-1anph6qi 9 8 partly partly RB cord-272015-1anph6qi 9 9 related relate VBN cord-272015-1anph6qi 9 10 to to IN cord-272015-1anph6qi 9 11 activated activate VBN cord-272015-1anph6qi 9 12 macrophages macrophage NNS cord-272015-1anph6qi 9 13 , , , cord-272015-1anph6qi 9 14 is be VBZ cord-272015-1anph6qi 9 15 widely widely RB cord-272015-1anph6qi 9 16 recognized recognize VBN cord-272015-1anph6qi 9 17 as as IN cord-272015-1anph6qi 9 18 an an DT cord-272015-1anph6qi 9 19 independent independent JJ cord-272015-1anph6qi 9 20 cause cause NN cord-272015-1anph6qi 9 21 of of IN cord-272015-1anph6qi 9 22 clinical clinical JJ cord-272015-1anph6qi 9 23 deterioration deterioration NN cord-272015-1anph6qi 9 24 and and CC cord-272015-1anph6qi 9 25 mortality mortality NN cord-272015-1anph6qi 9 26 in in IN cord-272015-1anph6qi 9 27 hospitalised hospitalise VBN cord-272015-1anph6qi 9 28 patients patient NNS cord-272015-1anph6qi 9 29 ( ( -LRB- cord-272015-1anph6qi 9 30 Webb Webb NNP cord-272015-1anph6qi 9 31 et et NNP cord-272015-1anph6qi 9 32 al al NNP cord-272015-1anph6qi 9 33 . . NNP cord-272015-1anph6qi 9 34 ; ; : cord-272015-1anph6qi 10 1 Del Del NNP cord-272015-1anph6qi 10 2 Valle Valle NNP cord-272015-1anph6qi 10 3 et et NNP cord-272015-1anph6qi 10 4 al al NNP cord-272015-1anph6qi 10 5 . . NNP cord-272015-1anph6qi 10 6 2020 2020 CD cord-272015-1anph6qi 10 7 ) ) -RRB- cord-272015-1anph6qi 10 8 . . . cord-272015-1anph6qi 11 1 Following follow VBG cord-272015-1anph6qi 11 2 the the DT cord-272015-1anph6qi 11 3 results result NNS cord-272015-1anph6qi 11 4 of of IN cord-272015-1anph6qi 11 5 the the DT cord-272015-1anph6qi 11 6 RECOVERY recovery NN cord-272015-1anph6qi 11 7 trial trial NN cord-272015-1anph6qi 11 8 and and CC cord-272015-1anph6qi 11 9 of of IN cord-272015-1anph6qi 11 10 an an DT cord-272015-1anph6qi 11 11 additional additional JJ cord-272015-1anph6qi 11 12 meta meta JJ cord-272015-1anph6qi 11 13 - - HYPH cord-272015-1anph6qi 11 14 analysis analysis NN cord-272015-1anph6qi 11 15 , , , cord-272015-1anph6qi 11 16 corticosteroids corticosteroid NNS cord-272015-1anph6qi 11 17 are be VBP cord-272015-1anph6qi 11 18 now now RB cord-272015-1anph6qi 11 19 recommended recommend VBN cord-272015-1anph6qi 11 20 as as IN cord-272015-1anph6qi 11 21 a a DT cord-272015-1anph6qi 11 22 standard standard NN cord-272015-1anph6qi 11 23 of of IN cord-272015-1anph6qi 11 24 care care NN cord-272015-1anph6qi 11 25 for for IN cord-272015-1anph6qi 11 26 hospitalized hospitalize VBN cord-272015-1anph6qi 11 27 patients patient NNS cord-272015-1anph6qi 11 28 with with IN cord-272015-1anph6qi 11 29 severe severe JJ cord-272015-1anph6qi 11 30 and and CC cord-272015-1anph6qi 11 31 critical critical JJ cord-272015-1anph6qi 11 32 COVID-19 covid-19 NN cord-272015-1anph6qi 11 33 ( ( -LRB- cord-272015-1anph6qi 11 34 WHO who WP cord-272015-1anph6qi 11 35 2020 2020 CD cord-272015-1anph6qi 11 36 ) ) -RRB- cord-272015-1anph6qi 11 37 . . . cord-272015-1anph6qi 12 1 Importantly importantly RB cord-272015-1anph6qi 12 2 , , , cord-272015-1anph6qi 12 3 the the DT cord-272015-1anph6qi 12 4 benefit benefit NN cord-272015-1anph6qi 12 5 of of IN cord-272015-1anph6qi 12 6 this this DT cord-272015-1anph6qi 12 7 anti anti JJ cord-272015-1anph6qi 12 8 - - JJ cord-272015-1anph6qi 12 9 inflammatory inflammatory JJ cord-272015-1anph6qi 12 10 intervention intervention NN cord-272015-1anph6qi 12 11 has have VBZ cord-272015-1anph6qi 12 12 been be VBN cord-272015-1anph6qi 12 13 observed observe VBN cord-272015-1anph6qi 12 14 with with IN cord-272015-1anph6qi 12 15 a a DT cord-272015-1anph6qi 12 16 low low JJ cord-272015-1anph6qi 12 17 dose dose NN cord-272015-1anph6qi 12 18 of of IN cord-272015-1anph6qi 12 19 dexamethasone dexamethasone NN cord-272015-1anph6qi 12 20 , , , cord-272015-1anph6qi 12 21 while while IN cord-272015-1anph6qi 12 22 observational observational JJ cord-272015-1anph6qi 12 23 studies study NNS cord-272015-1anph6qi 12 24 using use VBG cord-272015-1anph6qi 12 25 higher high JJR cord-272015-1anph6qi 12 26 dosage dosage NN cord-272015-1anph6qi 12 27 of of IN cord-272015-1anph6qi 12 28 corticosteroids corticosteroid NNS cord-272015-1anph6qi 12 29 have have VBP cord-272015-1anph6qi 12 30 not not RB cord-272015-1anph6qi 12 31 reported report VBN cord-272015-1anph6qi 12 32 any any DT cord-272015-1anph6qi 12 33 favourable favourable JJ cord-272015-1anph6qi 12 34 effect effect NN cord-272015-1anph6qi 12 35 on on IN cord-272015-1anph6qi 12 36 mortality mortality NN cord-272015-1anph6qi 12 37 ( ( -LRB- cord-272015-1anph6qi 12 38 Hasan Hasan NNP cord-272015-1anph6qi 12 39 et et NNP cord-272015-1anph6qi 12 40 al al NNP cord-272015-1anph6qi 12 41 . . NNP cord-272015-1anph6qi 12 42 2020 2020 CD cord-272015-1anph6qi 12 43 ) ) -RRB- cord-272015-1anph6qi 12 44 . . . cord-272015-1anph6qi 13 1 The the DT cord-272015-1anph6qi 13 2 observation observation NN cord-272015-1anph6qi 13 3 by by IN cord-272015-1anph6qi 13 4 Lammers Lammers NNP cord-272015-1anph6qi 13 5 et et NNP cord-272015-1anph6qi 13 6 al al NNP cord-272015-1anph6qi 13 7 ( ( -LRB- cord-272015-1anph6qi 13 8 Lammers Lammers NNP cord-272015-1anph6qi 13 9 et et NNP cord-272015-1anph6qi 13 10 al al NNP cord-272015-1anph6qi 13 11 . . . cord-272015-1anph6qi 13 12 ) ) -RRB- cord-272015-1anph6qi 14 1 that that DT cord-272015-1anph6qi 14 2 early early JJ cord-272015-1anph6qi 14 3 HCQ HCQ NNP cord-272015-1anph6qi 14 4 treatment treatment NN cord-272015-1anph6qi 14 5 after after IN cord-272015-1anph6qi 14 6 admission admission NN cord-272015-1anph6qi 14 7 at at IN cord-272015-1anph6qi 14 8 low low JJ cord-272015-1anph6qi 14 9 dosage dosage NN cord-272015-1anph6qi 14 10 ( ( -LRB- cord-272015-1anph6qi 14 11 2400 2400 CD cord-272015-1anph6qi 14 12 mg mg NN cord-272015-1anph6qi 14 13 in in IN cord-272015-1anph6qi 14 14 total total NN cord-272015-1anph6qi 14 15 ) ) -RRB- cord-272015-1anph6qi 14 16 is be VBZ cord-272015-1anph6qi 14 17 associated associate VBN cord-272015-1anph6qi 14 18 with with IN cord-272015-1anph6qi 14 19 lower low JJR cord-272015-1anph6qi 14 20 risk risk NN cord-272015-1anph6qi 14 21 of of IN cord-272015-1anph6qi 14 22 admission admission NN cord-272015-1anph6qi 14 23 in in IN cord-272015-1anph6qi 14 24 intensive intensive JJ cord-272015-1anph6qi 14 25 care care NN cord-272015-1anph6qi 14 26 unit unit NN cord-272015-1anph6qi 14 27 coincides coincide VBZ cord-272015-1anph6qi 14 28 with with IN cord-272015-1anph6qi 14 29 large large JJ cord-272015-1anph6qi 14 30 observational observational JJ cord-272015-1anph6qi 14 31 studies study NNS cord-272015-1anph6qi 14 32 showing show VBG cord-272015-1anph6qi 14 33 a a DT cord-272015-1anph6qi 14 34 lower low JJR cord-272015-1anph6qi 14 35 mortality mortality NN cord-272015-1anph6qi 14 36 rate rate NN cord-272015-1anph6qi 14 37 in in IN cord-272015-1anph6qi 14 38 patients patient NNS cord-272015-1anph6qi 14 39 exposed expose VBN cord-272015-1anph6qi 14 40 to to IN cord-272015-1anph6qi 14 41 HCQ hcq NN cord-272015-1anph6qi 14 42 therapy therapy NN cord-272015-1anph6qi 14 43 compared compare VBN cord-272015-1anph6qi 14 44 to to IN cord-272015-1anph6qi 14 45 no no DT cord-272015-1anph6qi 14 46 or or CC cord-272015-1anph6qi 14 47 other other JJ cord-272015-1anph6qi 14 48 treatment treatment NN cord-272015-1anph6qi 14 49 . . . cord-272015-1anph6qi 15 1 Of of IN cord-272015-1anph6qi 15 2 note note VB cord-272015-1anph6qi 15 3 , , , cord-272015-1anph6qi 15 4 in in IN cord-272015-1anph6qi 15 5 all all PDT cord-272015-1anph6qi 15 6 these these DT cord-272015-1anph6qi 15 7 studies study NNS cord-272015-1anph6qi 15 8 and and CC cord-272015-1anph6qi 15 9 in in IN cord-272015-1anph6qi 15 10 contrast contrast NN cord-272015-1anph6qi 15 11 to to IN cord-272015-1anph6qi 15 12 the the DT cord-272015-1anph6qi 15 13 RECOVERY recovery NN cord-272015-1anph6qi 15 14 trial trial NN cord-272015-1anph6qi 15 15 , , , cord-272015-1anph6qi 15 16 low low JJ cord-272015-1anph6qi 15 17 doses dose NNS cord-272015-1anph6qi 15 18 of of IN cord-272015-1anph6qi 15 19 HCQ HCQ NNP cord-272015-1anph6qi 15 20 ( ( -LRB- cord-272015-1anph6qi 15 21 < < NNP cord-272015-1anph6qi 15 22 2.5 2.5 CD cord-272015-1anph6qi 15 23 gr gr NNP cord-272015-1anph6qi 15 24 . . NNP cord-272015-1anph6qi 15 25 in in IN cord-272015-1anph6qi 15 26 total total NN cord-272015-1anph6qi 15 27 ) ) -RRB- cord-272015-1anph6qi 15 28 were be VBD cord-272015-1anph6qi 15 29 used use VBN cord-272015-1anph6qi 15 30 , , , cord-272015-1anph6qi 15 31 often often RB cord-272015-1anph6qi 15 32 soon soon RB cord-272015-1anph6qi 15 33 after after IN cord-272015-1anph6qi 15 34 admission admission NN cord-272015-1anph6qi 15 35 ( ( -LRB- cord-272015-1anph6qi 15 36 Arshad Arshad NNP cord-272015-1anph6qi 15 37 et et NNP cord-272015-1anph6qi 15 38 al al NNP cord-272015-1anph6qi 15 39 . . . cord-272015-1anph6qi 15 40 2020 2020 CD cord-272015-1anph6qi 15 41 ; ; : cord-272015-1anph6qi 15 42 Ayerbe Ayerbe NNP cord-272015-1anph6qi 15 43 et et NNP cord-272015-1anph6qi 15 44 al al NNP cord-272015-1anph6qi 15 45 . . NNP cord-272015-1anph6qi 15 46 2020 2020 CD cord-272015-1anph6qi 15 47 ; ; : cord-272015-1anph6qi 15 48 Catteau Catteau NNP cord-272015-1anph6qi 15 49 et et NNP cord-272015-1anph6qi 15 50 al al NNP cord-272015-1anph6qi 15 51 . . NNP cord-272015-1anph6qi 15 52 2020 2020 CD cord-272015-1anph6qi 15 53 ; ; . cord-272015-1anph6qi 16 1 COVID-19 covid-19 JJ cord-272015-1anph6qi 16 2 RISK RISK NNP cord-272015-1anph6qi 16 3 and and CC cord-272015-1anph6qi 16 4 Treatments Treatments NNP cord-272015-1anph6qi 16 5 ( ( -LRB- cord-272015-1anph6qi 16 6 CORIST CORIST NNP cord-272015-1anph6qi 16 7 ) ) -RRB- cord-272015-1anph6qi 16 8 Collaboration collaboration NN cord-272015-1anph6qi 16 9 2020 2020 CD cord-272015-1anph6qi 16 10 ) ) -RRB- cord-272015-1anph6qi 16 11 . . . cord-272015-1anph6qi 17 1 Another another DT cord-272015-1anph6qi 17 2 recent recent JJ cord-272015-1anph6qi 17 3 large large JJ cord-272015-1anph6qi 17 4 cohort cohort NN cord-272015-1anph6qi 17 5 study study NN cord-272015-1anph6qi 17 6 of of IN cord-272015-1anph6qi 17 7 patients patient NNS cord-272015-1anph6qi 17 8 on on IN cord-272015-1anph6qi 17 9 low low JJ cord-272015-1anph6qi 17 10 - - HYPH cord-272015-1anph6qi 17 11 dose dose NN cord-272015-1anph6qi 17 12 HCQ HCQ NNP cord-272015-1anph6qi 17 13 for for IN cord-272015-1anph6qi 17 14 inflammatory inflammatory JJ cord-272015-1anph6qi 17 15 disorders disorder NNS cord-272015-1anph6qi 17 16 reported report VBD cord-272015-1anph6qi 17 17 an an DT cord-272015-1anph6qi 17 18 association association NN cord-272015-1anph6qi 17 19 between between IN cord-272015-1anph6qi 17 20 chronic chronic JJ cord-272015-1anph6qi 17 21 HCQ HCQ NNP cord-272015-1anph6qi 17 22 use use NN cord-272015-1anph6qi 17 23 and and CC cord-272015-1anph6qi 17 24 reduced reduce VBN cord-272015-1anph6qi 17 25 mortality mortality NN cord-272015-1anph6qi 17 26 following follow VBG cord-272015-1anph6qi 17 27 SARS SARS NNP cord-272015-1anph6qi 17 28 - - HYPH cord-272015-1anph6qi 17 29 CoV-2 CoV-2 NNP cord-272015-1anph6qi 17 30 infection infection NN cord-272015-1anph6qi 18 1 ( ( -LRB- cord-272015-1anph6qi 18 2 Gentry Gentry NNP cord-272015-1anph6qi 18 3 et et NNP cord-272015-1anph6qi 18 4 al al NNP cord-272015-1anph6qi 18 5 . . NNP cord-272015-1anph6qi 18 6 2020 2020 CD cord-272015-1anph6qi 18 7 ) ) -RRB- cord-272015-1anph6qi 18 8 . . . cord-272015-1anph6qi 19 1 As as IN cord-272015-1anph6qi 19 2 highlighted highlight VBN cord-272015-1anph6qi 19 3 by by IN cord-272015-1anph6qi 19 4 the the DT cord-272015-1anph6qi 19 5 findings finding NNS cord-272015-1anph6qi 19 6 of of IN cord-272015-1anph6qi 19 7 Lammers Lammers NNP cord-272015-1anph6qi 19 8 et et NNP cord-272015-1anph6qi 19 9 al al NNP cord-272015-1anph6qi 19 10 , , , cord-272015-1anph6qi 19 11 the the DT cord-272015-1anph6qi 19 12 timing timing NN cord-272015-1anph6qi 19 13 of of IN cord-272015-1anph6qi 19 14 HCQ HCQ NNP cord-272015-1anph6qi 19 15 therapy therapy NN cord-272015-1anph6qi 19 16 ( ( -LRB- cord-272015-1anph6qi 19 17 administration administration NN cord-272015-1anph6qi 19 18 within within IN cord-272015-1anph6qi 19 19 1 1 CD cord-272015-1anph6qi 19 20 day day NN cord-272015-1anph6qi 19 21 of of IN cord-272015-1anph6qi 19 22 admission admission NN cord-272015-1anph6qi 19 23 ) ) -RRB- cord-272015-1anph6qi 19 24 could could MD cord-272015-1anph6qi 19 25 explain explain VB cord-272015-1anph6qi 19 26 discrepancies discrepancy NNS cord-272015-1anph6qi 19 27 between between IN cord-272015-1anph6qi 19 28 different different JJ cord-272015-1anph6qi 19 29 studies study NNS cord-272015-1anph6qi 19 30 . . . cord-272015-1anph6qi 20 1 In in IN cord-272015-1anph6qi 20 2 the the DT cord-272015-1anph6qi 20 3 RECOVERY recovery NN cord-272015-1anph6qi 20 4 trial trial NN cord-272015-1anph6qi 20 5 , , , cord-272015-1anph6qi 20 6 the the DT cord-272015-1anph6qi 20 7 median median JJ cord-272015-1anph6qi 20 8 time time NN cord-272015-1anph6qi 20 9 between between IN cord-272015-1anph6qi 20 10 symptoms symptom NNS cord-272015-1anph6qi 20 11 onset onset NN cord-272015-1anph6qi 20 12 and and CC cord-272015-1anph6qi 20 13 randomization randomization NN cord-272015-1anph6qi 20 14 was be VBD cord-272015-1anph6qi 20 15 9 9 CD cord-272015-1anph6qi 20 16 days day NNS cord-272015-1anph6qi 21 1 J J NNP cord-272015-1anph6qi 21 2 o o NN cord-272015-1anph6qi 21 3 u u NN cord-272015-1anph6qi 21 4 r r NN cord-272015-1anph6qi 21 5 n n NN cord-272015-1anph6qi 21 6 a a DT cord-272015-1anph6qi 21 7 l l NN cord-272015-1anph6qi 21 8 P p NN cord-272015-1anph6qi 21 9 r r NN cord-272015-1anph6qi 21 10 e e NN cord-272015-1anph6qi 21 11 -p -p NN cord-272015-1anph6qi 22 1 r r NNP cord-272015-1anph6qi 22 2 o o NN cord-272015-1anph6qi 22 3 o o NN cord-272015-1anph6qi 22 4 f f NN cord-272015-1anph6qi 22 5 and and CC cord-272015-1anph6qi 22 6 a a DT cord-272015-1anph6qi 22 7 substantial substantial JJ cord-272015-1anph6qi 22 8 proportion proportion NN cord-272015-1anph6qi 22 9 of of IN cord-272015-1anph6qi 22 10 patients patient NNS cord-272015-1anph6qi 22 11 ( ( -LRB- cord-272015-1anph6qi 22 12 16.7 16.7 CD cord-272015-1anph6qi 22 13 % % NN cord-272015-1anph6qi 22 14 ) ) -RRB- cord-272015-1anph6qi 22 15 was be VBD cord-272015-1anph6qi 22 16 already already RB cord-272015-1anph6qi 22 17 on on IN cord-272015-1anph6qi 22 18 mechanical mechanical JJ cord-272015-1anph6qi 22 19 ventilation ventilation NN cord-272015-1anph6qi 22 20 at at IN cord-272015-1anph6qi 22 21 randomization(The randomization(The NNP cord-272015-1anph6qi 22 22 RECOVERY RECOVERY NNP cord-272015-1anph6qi 22 23 Collaborative Collaborative NNP cord-272015-1anph6qi 22 24 Group Group NNP cord-272015-1anph6qi 22 25 2020 2020 CD cord-272015-1anph6qi 22 26 ) ) -RRB- cord-272015-1anph6qi 22 27 . . . cord-272015-1anph6qi 23 1 HCQ HCQ NNP cord-272015-1anph6qi 23 2 has have VBZ cord-272015-1anph6qi 23 3 been be VBN cord-272015-1anph6qi 23 4 used use VBN cord-272015-1anph6qi 23 5 as as IN cord-272015-1anph6qi 23 6 anti anti JJ cord-272015-1anph6qi 23 7 - - JJ cord-272015-1anph6qi 23 8 inflammatory inflammatory JJ cord-272015-1anph6qi 23 9 drug drug NN cord-272015-1anph6qi 23 10 for for IN cord-272015-1anph6qi 23 11 decades decade NNS cord-272015-1anph6qi 23 12 as as IN cord-272015-1anph6qi 23 13 therapy therapy NN cord-272015-1anph6qi 23 14 of of IN cord-272015-1anph6qi 23 15 inflammatory inflammatory JJ cord-272015-1anph6qi 23 16 disorders disorder NNS cord-272015-1anph6qi 23 17 and and CC cord-272015-1anph6qi 23 18 its -PRON- PRP$ cord-272015-1anph6qi 23 19 impact impact NN cord-272015-1anph6qi 23 20 on on IN cord-272015-1anph6qi 23 21 inflammatory inflammatory JJ cord-272015-1anph6qi 23 22 responses response NNS cord-272015-1anph6qi 23 23 is be VBZ cord-272015-1anph6qi 23 24 well well RB cord-272015-1anph6qi 23 25 documented document VBN cord-272015-1anph6qi 23 26 . . . cord-272015-1anph6qi 24 1 HCQ HCQ NNP cord-272015-1anph6qi 24 2 inhibits inhibit VBZ cord-272015-1anph6qi 24 3 the the DT cord-272015-1anph6qi 24 4 production production NN cord-272015-1anph6qi 24 5 of of IN cord-272015-1anph6qi 24 6 the the DT cord-272015-1anph6qi 24 7 pro pro JJ cord-272015-1anph6qi 24 8 - - JJ cord-272015-1anph6qi 24 9 inflammatory inflammatory JJ cord-272015-1anph6qi 24 10 cytokines cytokine NNS cord-272015-1anph6qi 24 11 interleukin interleukin NN cord-272015-1anph6qi 24 12 ( ( -LRB- cord-272015-1anph6qi 24 13 IL)-6 IL)-6 NNP cord-272015-1anph6qi 24 14 , , , cord-272015-1anph6qi 24 15 TNF TNF NNP cord-272015-1anph6qi 24 16 - - HYPH cord-272015-1anph6qi 24 17 α α NNP cord-272015-1anph6qi 24 18 and and CC cord-272015-1anph6qi 24 19 IL-1-β il-1-β IN cord-272015-1anph6qi 24 20 by by IN cord-272015-1anph6qi 24 21 activated activate VBN cord-272015-1anph6qi 24 22 macrophages macrophage NNS cord-272015-1anph6qi 24 23 ( ( -LRB- cord-272015-1anph6qi 24 24 Sperber Sperber NNP cord-272015-1anph6qi 24 25 et et NNP cord-272015-1anph6qi 24 26 al al NNP cord-272015-1anph6qi 24 27 . . . cord-272015-1anph6qi 24 28 1993 1993 CD cord-272015-1anph6qi 25 1 ; ; : cord-272015-1anph6qi 25 2 Jang Jang NNP cord-272015-1anph6qi 25 3 et et FW cord-272015-1anph6qi 25 4 al al NNP cord-272015-1anph6qi 25 5 . . . cord-272015-1anph6qi 25 6 2006 2006 CD cord-272015-1anph6qi 25 7 ) ) -RRB- cord-272015-1anph6qi 25 8 , , , cord-272015-1anph6qi 25 9 which which WDT cord-272015-1anph6qi 25 10 are be VBP cord-272015-1anph6qi 25 11 notoriously notoriously RB cord-272015-1anph6qi 25 12 associated associate VBN cord-272015-1anph6qi 25 13 with with IN cord-272015-1anph6qi 25 14 COVID-19 covid-19 JJ cord-272015-1anph6qi 25 15 severity severity NN cord-272015-1anph6qi 25 16 ( ( -LRB- cord-272015-1anph6qi 25 17 Webb Webb NNP cord-272015-1anph6qi 25 18 et et NNP cord-272015-1anph6qi 25 19 al al NNP cord-272015-1anph6qi 25 20 . . NNP cord-272015-1anph6qi 25 21 ; ; : cord-272015-1anph6qi 26 1 Del Del NNP cord-272015-1anph6qi 26 2 Valle Valle NNP cord-272015-1anph6qi 26 3 et et NNP cord-272015-1anph6qi 26 4 al al NNP cord-272015-1anph6qi 26 5 . . NNP cord-272015-1anph6qi 26 6 2020 2020 CD cord-272015-1anph6qi 26 7 ) ) -RRB- cord-272015-1anph6qi 26 8 and and CC cord-272015-1anph6qi 26 9 also also RB cord-272015-1anph6qi 26 10 the the DT cord-272015-1anph6qi 26 11 production production NN cord-272015-1anph6qi 26 12 of of IN cord-272015-1anph6qi 26 13 chemotactic chemotactic JJ cord-272015-1anph6qi 26 14 cytokines cytokine NNS cord-272015-1anph6qi 26 15 involved involve VBN cord-272015-1anph6qi 26 16 in in IN cord-272015-1anph6qi 26 17 the the DT cord-272015-1anph6qi 26 18 recruitment recruitment NN cord-272015-1anph6qi 26 19 of of IN cord-272015-1anph6qi 26 20 pro pro JJ cord-272015-1anph6qi 26 21 - - JJ cord-272015-1anph6qi 26 22 inflammatory inflammatory JJ cord-272015-1anph6qi 26 23 cells cell NNS cord-272015-1anph6qi 26 24 in in IN cord-272015-1anph6qi 26 25 the the DT cord-272015-1anph6qi 26 26 lungs(Grassin lungs(Grassin NNP cord-272015-1anph6qi 26 27 - - HYPH cord-272015-1anph6qi 26 28 Delyle Delyle NNP cord-272015-1anph6qi 26 29 et et FW cord-272015-1anph6qi 26 30 al al NNP cord-272015-1anph6qi 26 31 . . NNP cord-272015-1anph6qi 26 32 2020 2020 CD cord-272015-1anph6qi 26 33 ) ) -RRB- cord-272015-1anph6qi 26 34 . . . cord-272015-1anph6qi 27 1 In in IN cord-272015-1anph6qi 27 2 line line NN cord-272015-1anph6qi 27 3 with with IN cord-272015-1anph6qi 27 4 this this DT cord-272015-1anph6qi 27 5 , , , cord-272015-1anph6qi 27 6 an an DT cord-272015-1anph6qi 27 7 Italian italian JJ cord-272015-1anph6qi 27 8 study study NN cord-272015-1anph6qi 27 9 suggests suggest VBZ cord-272015-1anph6qi 27 10 that that IN cord-272015-1anph6qi 27 11 the the DT cord-272015-1anph6qi 27 12 benefit benefit NN cord-272015-1anph6qi 27 13 of of IN cord-272015-1anph6qi 27 14 HCQ HCQ NNP cord-272015-1anph6qi 27 15 was be VBD cord-272015-1anph6qi 27 16 restricted restrict VBN cord-272015-1anph6qi 27 17 to to IN cord-272015-1anph6qi 27 18 patients patient NNS cord-272015-1anph6qi 27 19 with with IN cord-272015-1anph6qi 27 20 elevated elevated JJ cord-272015-1anph6qi 27 21 C c NN cord-272015-1anph6qi 27 22 - - HYPH cord-272015-1anph6qi 27 23 reactive reactive JJ cord-272015-1anph6qi 27 24 protein protein NN cord-272015-1anph6qi 27 25 levels(COVID-19 levels(covid-19 JJ cord-272015-1anph6qi 27 26 RISK risk NN cord-272015-1anph6qi 27 27 and and CC cord-272015-1anph6qi 27 28 Treatments Treatments NNP cord-272015-1anph6qi 27 29 ( ( -LRB- cord-272015-1anph6qi 27 30 CORIST CORIST NNP cord-272015-1anph6qi 27 31 ) ) -RRB- cord-272015-1anph6qi 27 32 Collaboration collaboration NN cord-272015-1anph6qi 27 33 2020 2020 CD cord-272015-1anph6qi 27 34 ) ) -RRB- cord-272015-1anph6qi 27 35 . . . cord-272015-1anph6qi 28 1 Thrombotic thrombotic JJ cord-272015-1anph6qi 28 2 events event NNS cord-272015-1anph6qi 28 3 are be VBP cord-272015-1anph6qi 28 4 another another DT cord-272015-1anph6qi 28 5 well well RB cord-272015-1anph6qi 28 6 recognized recognize VBN cord-272015-1anph6qi 28 7 complication complication NN cord-272015-1anph6qi 28 8 of of IN cord-272015-1anph6qi 28 9 severe severe JJ cord-272015-1anph6qi 28 10 COVID-19 covid-19 NN cord-272015-1anph6qi 28 11 ( ( -LRB- cord-272015-1anph6qi 28 12 Llitjos Llitjos NNP cord-272015-1anph6qi 28 13 et et NNP cord-272015-1anph6qi 28 14 al al NNP cord-272015-1anph6qi 28 15 . . NNP cord-272015-1anph6qi 28 16 2020 2020 CD cord-272015-1anph6qi 28 17 ) ) -RRB- cord-272015-1anph6qi 29 1 and and CC cord-272015-1anph6qi 29 2 the the DT cord-272015-1anph6qi 29 3 presence presence NN cord-272015-1anph6qi 29 4 of of IN cord-272015-1anph6qi 29 5 lupus lupus NN cord-272015-1anph6qi 29 6 anticoagulant anticoagulant NN cord-272015-1anph6qi 29 7 has have VBZ cord-272015-1anph6qi 29 8 been be VBN cord-272015-1anph6qi 29 9 reported report VBN cord-272015-1anph6qi 29 10 in in IN cord-272015-1anph6qi 29 11 hospitalised hospitalise VBN cord-272015-1anph6qi 29 12 COVID-19 COVID-19 NNP cord-272015-1anph6qi 29 13 ( ( -LRB- cord-272015-1anph6qi 29 14 Bowles Bowles NNP cord-272015-1anph6qi 29 15 et et NNP cord-272015-1anph6qi 29 16 al al NNP cord-272015-1anph6qi 29 17 . . NNP cord-272015-1anph6qi 29 18 2020 2020 CD cord-272015-1anph6qi 29 19 ) ) -RRB- cord-272015-1anph6qi 29 20 . . . cord-272015-1anph6qi 30 1 HCQ hcq NN cord-272015-1anph6qi 30 2 therapy therapy NN cord-272015-1anph6qi 30 3 has have VBZ cord-272015-1anph6qi 30 4 been be VBN cord-272015-1anph6qi 30 5 associated associate VBN cord-272015-1anph6qi 30 6 with with IN cord-272015-1anph6qi 30 7 a a DT cord-272015-1anph6qi 30 8 decrease decrease NN cord-272015-1anph6qi 30 9 of of IN cord-272015-1anph6qi 30 10 lupus lupus NN cord-272015-1anph6qi 30 11 anticoagulant anticoagulant JJ cord-272015-1anph6qi 30 12 levels level NNS cord-272015-1anph6qi 30 13 as as RB cord-272015-1anph6qi 30 14 well well RB cord-272015-1anph6qi 30 15 as as IN cord-272015-1anph6qi 30 16 of of IN cord-272015-1anph6qi 30 17 platelet platelet NN cord-272015-1anph6qi 30 18 activation activation NN cord-272015-1anph6qi 30 19 and and CC cord-272015-1anph6qi 30 20 thrombotic thrombotic JJ cord-272015-1anph6qi 30 21 events event NNS cord-272015-1anph6qi 30 22 in in IN cord-272015-1anph6qi 30 23 lupus lupus NN cord-272015-1anph6qi 30 24 patients patient NNS cord-272015-1anph6qi 30 25 ( ( -LRB- cord-272015-1anph6qi 30 26 Broder Broder NNP cord-272015-1anph6qi 30 27 and and CC cord-272015-1anph6qi 30 28 Putterman Putterman NNP cord-272015-1anph6qi 30 29 2013 2013 CD cord-272015-1anph6qi 30 30 ) ) -RRB- cord-272015-1anph6qi 30 31 . . . cord-272015-1anph6qi 31 1 Interestingly interestingly RB cord-272015-1anph6qi 31 2 , , , cord-272015-1anph6qi 31 3 B b NN cord-272015-1anph6qi 31 4 cell cell NN cord-272015-1anph6qi 31 5 abnormalities abnormality NNS cord-272015-1anph6qi 31 6 similar similar JJ cord-272015-1anph6qi 31 7 to to IN cord-272015-1anph6qi 31 8 those those DT cord-272015-1anph6qi 31 9 reported report VBN cord-272015-1anph6qi 31 10 in in IN cord-272015-1anph6qi 31 11 autoimmune autoimmune JJ cord-272015-1anph6qi 31 12 disease disease NN cord-272015-1anph6qi 31 13 such such JJ cord-272015-1anph6qi 31 14 as as IN cord-272015-1anph6qi 31 15 active active JJ cord-272015-1anph6qi 31 16 lupus lupus NN cord-272015-1anph6qi 31 17 were be VBD cord-272015-1anph6qi 31 18 reported report VBN cord-272015-1anph6qi 31 19 in in IN cord-272015-1anph6qi 31 20 patients patient NNS cord-272015-1anph6qi 31 21 with with IN cord-272015-1anph6qi 31 22 severe severe JJ cord-272015-1anph6qi 31 23 COVID-19 COVID-19 NNP cord-272015-1anph6qi 31 24 ( ( -LRB- cord-272015-1anph6qi 31 25 Woodruff Woodruff NNP cord-272015-1anph6qi 31 26 et et NNP cord-272015-1anph6qi 31 27 al al NNP cord-272015-1anph6qi 31 28 . . NNP cord-272015-1anph6qi 31 29 2020 2020 CD cord-272015-1anph6qi 31 30 ) ) -RRB- cord-272015-1anph6qi 31 31 . . . cord-272015-1anph6qi 32 1 HCQ HCQ NNP cord-272015-1anph6qi 32 2 has have VBZ cord-272015-1anph6qi 32 3 no no DT cord-272015-1anph6qi 32 4 antiviral antiviral JJ cord-272015-1anph6qi 32 5 activity activity NN cord-272015-1anph6qi 32 6 in in IN cord-272015-1anph6qi 32 7 vivo vivo NN cord-272015-1anph6qi 32 8 against against IN cord-272015-1anph6qi 32 9 SARS SARS NNP cord-272015-1anph6qi 32 10 - - HYPH cord-272015-1anph6qi 32 11 CoV-2 CoV-2 NNP cord-272015-1anph6qi 32 12 as as IN cord-272015-1anph6qi 32 13 shown show VBN cord-272015-1anph6qi 32 14 in in IN cord-272015-1anph6qi 32 15 pre pre JJ cord-272015-1anph6qi 32 16 - - JJ cord-272015-1anph6qi 32 17 clinical clinical JJ cord-272015-1anph6qi 32 18 models model NNS cord-272015-1anph6qi 32 19 such such JJ cord-272015-1anph6qi 32 20 as as IN cord-272015-1anph6qi 32 21 Syrian syrian JJ cord-272015-1anph6qi 32 22 hamsters hamster NNS cord-272015-1anph6qi 32 23 , , , cord-272015-1anph6qi 32 24 non non JJ cord-272015-1anph6qi 32 25 - - JJ cord-272015-1anph6qi 32 26 human human JJ cord-272015-1anph6qi 32 27 primates primate NNS cord-272015-1anph6qi 32 28 and and CC cord-272015-1anph6qi 32 29 human human JJ cord-272015-1anph6qi 32 30 lung lung NN cord-272015-1anph6qi 32 31 cells cell NNS cord-272015-1anph6qi 32 32 , , , cord-272015-1anph6qi 32 33 and and CC cord-272015-1anph6qi 32 34 should should MD cord-272015-1anph6qi 32 35 therefore therefore RB cord-272015-1anph6qi 32 36 not not RB cord-272015-1anph6qi 32 37 be be VB cord-272015-1anph6qi 32 38 used use VBN cord-272015-1anph6qi 32 39 as as IN cord-272015-1anph6qi 32 40 antiviral antiviral JJ cord-272015-1anph6qi 32 41 therapy therapy NN cord-272015-1anph6qi 32 42 in in IN cord-272015-1anph6qi 32 43 COVID-19 COVID-19 NNP cord-272015-1anph6qi 32 44 ( ( -LRB- cord-272015-1anph6qi 32 45 Maisonnasse Maisonnasse NNP cord-272015-1anph6qi 32 46 et et FW cord-272015-1anph6qi 32 47 al al NNP cord-272015-1anph6qi 32 48 . . NNP cord-272015-1anph6qi 32 49 2020 2020 CD cord-272015-1anph6qi 32 50 ) ) -RRB- cord-272015-1anph6qi 32 51 . . . cord-272015-1anph6qi 33 1 However however RB cord-272015-1anph6qi 33 2 , , , cord-272015-1anph6qi 33 3 to to TO cord-272015-1anph6qi 33 4 further further RB cord-272015-1anph6qi 33 5 understand understand VB cord-272015-1anph6qi 33 6 the the DT cord-272015-1anph6qi 33 7 positive positive JJ cord-272015-1anph6qi 33 8 effects effect NNS cord-272015-1anph6qi 33 9 observed observe VBN cord-272015-1anph6qi 33 10 in in IN cord-272015-1anph6qi 33 11 large large JJ cord-272015-1anph6qi 33 12 observational observational JJ cord-272015-1anph6qi 33 13 studies study NNS cord-272015-1anph6qi 33 14 that that WDT cord-272015-1anph6qi 33 15 used use VBD cord-272015-1anph6qi 33 16 HCQ HCQ NNP cord-272015-1anph6qi 33 17 offlabel offlabel NN cord-272015-1anph6qi 33 18 in in IN cord-272015-1anph6qi 33 19 the the DT cord-272015-1anph6qi 33 20 early early JJ cord-272015-1anph6qi 33 21 months month NNS cord-272015-1anph6qi 33 22 of of IN cord-272015-1anph6qi 33 23 the the DT cord-272015-1anph6qi 33 24 pandemic pandemic NN cord-272015-1anph6qi 33 25 , , , cord-272015-1anph6qi 33 26 the the DT cord-272015-1anph6qi 33 27 hypothesis hypothesis NN cord-272015-1anph6qi 33 28 of of IN cord-272015-1anph6qi 33 29 an an DT cord-272015-1anph6qi 33 30 anti anti JJ cord-272015-1anph6qi 33 31 - - JJ cord-272015-1anph6qi 33 32 inflammatory inflammatory JJ cord-272015-1anph6qi 33 33 action action NN cord-272015-1anph6qi 33 34 J J NNP cord-272015-1anph6qi 33 35 o o NN cord-272015-1anph6qi 33 36 u u NN cord-272015-1anph6qi 33 37 r r NN cord-272015-1anph6qi 33 38 n n NN cord-272015-1anph6qi 33 39 a a DT cord-272015-1anph6qi 33 40 l l NN cord-272015-1anph6qi 33 41 P p NN cord-272015-1anph6qi 33 42 r r NN cord-272015-1anph6qi 33 43 e e NN cord-272015-1anph6qi 33 44 -p -p NN cord-272015-1anph6qi 33 45 r r NN cord-272015-1anph6qi 33 46 o o NN cord-272015-1anph6qi 33 47 o o NN cord-272015-1anph6qi 33 48 f f NN cord-272015-1anph6qi 33 49 4 4 CD cord-272015-1anph6qi 33 50 should should MD cord-272015-1anph6qi 33 51 not not RB cord-272015-1anph6qi 33 52 be be VB cord-272015-1anph6qi 33 53 discarded discard VBN cord-272015-1anph6qi 33 54 . . . cord-272015-1anph6qi 34 1 We -PRON- PRP cord-272015-1anph6qi 34 2 suggest suggest VBP cord-272015-1anph6qi 34 3 that that IN cord-272015-1anph6qi 34 4 ongoing ongoing JJ cord-272015-1anph6qi 34 5 trials trial NNS cord-272015-1anph6qi 34 6 evaluating evaluate VBG cord-272015-1anph6qi 34 7 HCQ HCQ NNP cord-272015-1anph6qi 34 8 specifically specifically RB cord-272015-1anph6qi 34 9 look look VB cord-272015-1anph6qi 34 10 at at IN cord-272015-1anph6qi 34 11 its -PRON- PRP$ cord-272015-1anph6qi 34 12 effect effect NN cord-272015-1anph6qi 34 13 on on IN cord-272015-1anph6qi 34 14 inflammatory inflammatory JJ cord-272015-1anph6qi 34 15 parameters parameter NNS cord-272015-1anph6qi 34 16 with with IN cord-272015-1anph6qi 34 17 add add VB cord-272015-1anph6qi 34 18 - - HYPH cord-272015-1anph6qi 34 19 on on RP cord-272015-1anph6qi 34 20 studies study NNS cord-272015-1anph6qi 34 21 if if IN cord-272015-1anph6qi 34 22 necessary necessary JJ cord-272015-1anph6qi 34 23 . . . cord-272015-1anph6qi 35 1 In in IN cord-272015-1anph6qi 35 2 the the DT cord-272015-1anph6qi 35 3 same same JJ cord-272015-1anph6qi 35 4 line line NN cord-272015-1anph6qi 35 5 , , , cord-272015-1anph6qi 35 6 ongoing ongoing JJ cord-272015-1anph6qi 35 7 trials trial NNS cord-272015-1anph6qi 35 8 are be VBP cord-272015-1anph6qi 35 9 investigating investigate VBG cord-272015-1anph6qi 35 10 colchicine colchicine NNP cord-272015-1anph6qi 35 11 to to TO cord-272015-1anph6qi 35 12 prevent prevent VB cord-272015-1anph6qi 35 13 hospitalisation hospitalisation NN cord-272015-1anph6qi 35 14 in in IN cord-272015-1anph6qi 35 15 SARS SARS NNP cord-272015-1anph6qi 35 16 - - HYPH cord-272015-1anph6qi 35 17 CoV-2 CoV-2 NNP cord-272015-1anph6qi 35 18 infected infected JJ cord-272015-1anph6qi 35 19 subjects subject NNS cord-272015-1anph6qi 35 20 , , , cord-272015-1anph6qi 35 21 and and CC cord-272015-1anph6qi 35 22 the the DT cord-272015-1anph6qi 35 23 rationale rationale NN cord-272015-1anph6qi 35 24 is be VBZ cord-272015-1anph6qi 35 25 based base VBN cord-272015-1anph6qi 35 26 on on IN cord-272015-1anph6qi 35 27 anti anti JJ cord-272015-1anph6qi 35 28 - - JJ cord-272015-1anph6qi 35 29 inflammatory inflammatory JJ cord-272015-1anph6qi 35 30 properties property NNS cord-272015-1anph6qi 35 31 , , , cord-272015-1anph6qi 35 32 that that WDT cord-272015-1anph6qi 35 33 are be VBP cord-272015-1anph6qi 35 34 partly partly RB cord-272015-1anph6qi 35 35 shared share VBN cord-272015-1anph6qi 35 36 _SP cord-272015-1anph6qi 35 37 Treatment Treatment NNP cord-272015-1anph6qi 35 38 with with IN cord-272015-1anph6qi 35 39 hydroxychloroquine hydroxychloroquine NN cord-272015-1anph6qi 35 40 , , , cord-272015-1anph6qi 35 41 azithromycin azithromycin NNP cord-272015-1anph6qi 35 42 , , , cord-272015-1anph6qi 35 43 and and CC cord-272015-1anph6qi 35 44 combination combination NN cord-272015-1anph6qi 35 45 in in IN cord-272015-1anph6qi 35 46 patients patient NNS cord-272015-1anph6qi 35 47 hospitalized hospitalize VBN cord-272015-1anph6qi 35 48 with with IN cord-272015-1anph6qi 35 49 COVID-19 COVID-19 NNP cord-272015-1anph6qi 35 50 The the DT cord-272015-1anph6qi 35 51 association association NN cord-272015-1anph6qi 35 52 of of IN cord-272015-1anph6qi 35 53 treatment treatment NN cord-272015-1anph6qi 35 54 with with IN cord-272015-1anph6qi 35 55 hydroxychloroquine hydroxychloroquine NN cord-272015-1anph6qi 35 56 and and CC cord-272015-1anph6qi 35 57 hospital hospital NN cord-272015-1anph6qi 35 58 mortality mortality NN cord-272015-1anph6qi 35 59 in in IN cord-272015-1anph6qi 35 60 COVID-19 COVID-19 NNP cord-272015-1anph6qi 35 61 patients patient NNS cord-272015-1anph6qi 35 62 Hydroxychloroquine Hydroxychloroquine NNP cord-272015-1anph6qi 35 63 : : : cord-272015-1anph6qi 35 64 from from IN cord-272015-1anph6qi 35 65 malaria malaria NN cord-272015-1anph6qi 35 66 to to IN cord-272015-1anph6qi 35 67 autoimmunity autoimmunity NN cord-272015-1anph6qi 35 68 Lupus Lupus NNP cord-272015-1anph6qi 35 69 Anticoagulant Anticoagulant NNP cord-272015-1anph6qi 35 70 and and CC cord-272015-1anph6qi 35 71 Abnormal abnormal JJ cord-272015-1anph6qi 35 72 Coagulation coagulation NN cord-272015-1anph6qi 35 73 Tests test NNS cord-272015-1anph6qi 35 74 in in IN cord-272015-1anph6qi 35 75 Patients patient NNS cord-272015-1anph6qi 35 76 with with IN cord-272015-1anph6qi 35 77 Covid-19 Covid-19 NNP cord-272015-1anph6qi 35 78 Hydroxychloroquine Hydroxychloroquine NNP cord-272015-1anph6qi 35 79 Use Use NNP cord-272015-1anph6qi 36 1 Is be VBZ cord-272015-1anph6qi 36 2 Associated associate VBN cord-272015-1anph6qi 36 3 with with IN cord-272015-1anph6qi 36 4 Lower low JJR cord-272015-1anph6qi 36 5 Odds odd NNS cord-272015-1anph6qi 36 6 of of IN cord-272015-1anph6qi 36 7 Persistently persistently RB cord-272015-1anph6qi 36 8 Positive Positive NNP cord-272015-1anph6qi 36 9 Antiphospholipid Antiphospholipid NNP cord-272015-1anph6qi 36 10 Antibodies Antibodies NNPS cord-272015-1anph6qi 36 11 and/or and/or CC cord-272015-1anph6qi 36 12 Lupus Lupus NNP cord-272015-1anph6qi 36 13 Anticoagulant Anticoagulant NNP cord-272015-1anph6qi 36 14 in in IN cord-272015-1anph6qi 36 15 Systemic Systemic NNP cord-272015-1anph6qi 36 16 Lupus Lupus NNP cord-272015-1anph6qi 36 17 Erythematosus Erythematosus NNP cord-272015-1anph6qi 36 18 Low low JJ cord-272015-1anph6qi 36 19 - - HYPH cord-272015-1anph6qi 36 20 dose dose NN cord-272015-1anph6qi 36 21 hydroxychloroquine hydroxychloroquine NN cord-272015-1anph6qi 36 22 therapy therapy NN cord-272015-1anph6qi 36 23 and and CC cord-272015-1anph6qi 36 24 mortality mortality NN cord-272015-1anph6qi 36 25 in in IN cord-272015-1anph6qi 36 26 hospitalised hospitalise VBN cord-272015-1anph6qi 36 27 patients patient NNS cord-272015-1anph6qi 36 28 with with IN cord-272015-1anph6qi 36 29 COVID-19 COVID-19 NNP cord-272015-1anph6qi 36 30 : : : cord-272015-1anph6qi 36 31 a a DT cord-272015-1anph6qi 36 32 nationwide nationwide JJ cord-272015-1anph6qi 36 33 observational observational JJ cord-272015-1anph6qi 36 34 study study NN cord-272015-1anph6qi 36 35 of of IN cord-272015-1anph6qi 36 36 8075 8075 CD cord-272015-1anph6qi 36 37 participants participant NNS cord-272015-1anph6qi 36 38 Use Use NNP cord-272015-1anph6qi 36 39 of of IN cord-272015-1anph6qi 36 40 hydroxychloroquine hydroxychloroquine NN cord-272015-1anph6qi 36 41 in in IN cord-272015-1anph6qi 36 42 hospitalised hospitalise VBN cord-272015-1anph6qi 36 43 COVID-19 COVID-19 NNP cord-272015-1anph6qi 36 44 patients patient NNS cord-272015-1anph6qi 36 45 is be VBZ cord-272015-1anph6qi 36 46 associated associate VBN cord-272015-1anph6qi 36 47 with with IN cord-272015-1anph6qi 36 48 reduced reduce VBN cord-272015-1anph6qi 36 49 mortality mortality NN cord-272015-1anph6qi 36 50 : : : cord-272015-1anph6qi 36 51 Findings finding NNS cord-272015-1anph6qi 36 52 from from IN cord-272015-1anph6qi 36 53 the the DT cord-272015-1anph6qi 36 54 observational observational JJ cord-272015-1anph6qi 36 55 multicentre multicentre NN cord-272015-1anph6qi 37 1 Italian italian JJ cord-272015-1anph6qi 37 2 CORIST CORIST NNP cord-272015-1anph6qi 37 3 study study NN cord-272015-1anph6qi 38 1 An an DT cord-272015-1anph6qi 38 2 inflammatory inflammatory JJ cord-272015-1anph6qi 38 3 cytokine cytokine NN cord-272015-1anph6qi 38 4 signature signature NN cord-272015-1anph6qi 38 5 predicts predict VBZ cord-272015-1anph6qi 38 6 COVID-19 covid-19 JJ cord-272015-1anph6qi 38 7 severity severity NN cord-272015-1anph6qi 38 8 and and CC cord-272015-1anph6qi 38 9 survival survival NN cord-272015-1anph6qi 38 10 Longterm Longterm NNP cord-272015-1anph6qi 38 11 hydroxychloroquine hydroxychloroquine NN cord-272015-1anph6qi 38 12 use use NN cord-272015-1anph6qi 38 13 in in IN cord-272015-1anph6qi 38 14 patients patient NNS cord-272015-1anph6qi 38 15 with with IN cord-272015-1anph6qi 38 16 rheumatic rheumatic JJ cord-272015-1anph6qi 38 17 conditions condition NNS cord-272015-1anph6qi 38 18 and and CC cord-272015-1anph6qi 38 19 development development NN cord-272015-1anph6qi 38 20 of of IN cord-272015-1anph6qi 38 21 SARS SARS NNP cord-272015-1anph6qi 38 22 - - HYPH cord-272015-1anph6qi 38 23 CoV-2 CoV-2 NNP cord-272015-1anph6qi 38 24 infection infection NN cord-272015-1anph6qi 38 25 : : : cord-272015-1anph6qi 38 26 a a DT cord-272015-1anph6qi 38 27 retrospective retrospective JJ cord-272015-1anph6qi 38 28 cohort cohort NN cord-272015-1anph6qi 38 29 study study NN cord-272015-1anph6qi 39 1 Chloroquine Chloroquine NNP cord-272015-1anph6qi 39 2 inhibits inhibit VBZ cord-272015-1anph6qi 39 3 the the DT cord-272015-1anph6qi 39 4 release release NN cord-272015-1anph6qi 39 5 of of IN cord-272015-1anph6qi 39 6 inflammatory inflammatory JJ cord-272015-1anph6qi 39 7 cytokines cytokine NNS cord-272015-1anph6qi 39 8 by by IN cord-272015-1anph6qi 39 9 human human JJ cord-272015-1anph6qi 39 10 lung lung NN cord-272015-1anph6qi 39 11 explants explant NNS cord-272015-1anph6qi 39 12 Mortality Mortality NNP cord-272015-1anph6qi 39 13 in in IN cord-272015-1anph6qi 39 14 COVID-19 covid-19 JJ cord-272015-1anph6qi 39 15 patients patient NNS cord-272015-1anph6qi 39 16 with with IN cord-272015-1anph6qi 39 17 acute acute JJ cord-272015-1anph6qi 39 18 respiratory respiratory JJ cord-272015-1anph6qi 39 19 distress distress NN cord-272015-1anph6qi 39 20 syndrome syndrome NN cord-272015-1anph6qi 39 21 and and CC cord-272015-1anph6qi 39 22 corticosteroids corticosteroid NNS cord-272015-1anph6qi 39 23 use use VBP cord-272015-1anph6qi 39 24 : : : cord-272015-1anph6qi 39 25 a a DT cord-272015-1anph6qi 39 26 systematic systematic JJ cord-272015-1anph6qi 39 27 review review NN cord-272015-1anph6qi 39 28 and and CC cord-272015-1anph6qi 39 29 meta meta NNP cord-272015-1anph6qi 39 30 - - HYPH cord-272015-1anph6qi 39 31 analysis analysis NN cord-272015-1anph6qi 40 1 Chloroquine Chloroquine NNP cord-272015-1anph6qi 40 2 inhibits inhibit VBZ cord-272015-1anph6qi 40 3 production production NN cord-272015-1anph6qi 40 4 of of IN cord-272015-1anph6qi 40 5 TNF TNF NNP cord-272015-1anph6qi 40 6 - - HYPH cord-272015-1anph6qi 40 7 α α NNP cord-272015-1anph6qi 40 8 , , , cord-272015-1anph6qi 40 9 IL-1β IL-1β NNP cord-272015-1anph6qi 40 10 and and CC cord-272015-1anph6qi 40 11 IL-6 IL-6 NNP cord-272015-1anph6qi 40 12 from from IN cord-272015-1anph6qi 41 1 lipopolysaccharide lipopolysaccharide NN cord-272015-1anph6qi 41 2 - - HYPH cord-272015-1anph6qi 41 3 stimulated stimulate VBN cord-272015-1anph6qi 41 4 human human JJ cord-272015-1anph6qi 41 5 monocytes monocyte NNS cord-272015-1anph6qi 41 6 / / SYM cord-272015-1anph6qi 41 7 macrophages macrophage NNS cord-272015-1anph6qi 41 8 by by IN cord-272015-1anph6qi 41 9 different different JJ cord-272015-1anph6qi 41 10 modes mode NNS cord-272015-1anph6qi 41 11 Early Early NNP cord-272015-1anph6qi 41 12 Hydroxychloroquine Hydroxychloroquine NNP cord-272015-1anph6qi 41 13 but but CC cord-272015-1anph6qi 41 14 not not RB cord-272015-1anph6qi 41 15 Chloroquine Chloroquine NNP cord-272015-1anph6qi 41 16 use use NN cord-272015-1anph6qi 41 17 reduces reduce VBZ cord-272015-1anph6qi 41 18 ICU ICU NNP cord-272015-1anph6qi 41 19 admission admission NN cord-272015-1anph6qi 41 20 in in IN cord-272015-1anph6qi 41 21 COVID-19 COVID-19 NNP cord-272015-1anph6qi 41 22 patients patient NNS cord-272015-1anph6qi 41 23 High high JJ cord-272015-1anph6qi 41 24 incidence incidence NN cord-272015-1anph6qi 41 25 of of IN cord-272015-1anph6qi 41 26 venous venous JJ cord-272015-1anph6qi 41 27 thromboembolic thromboembolic JJ cord-272015-1anph6qi 41 28 events event NNS cord-272015-1anph6qi 41 29 in in IN cord-272015-1anph6qi 41 30 anticoagulated anticoagulated JJ cord-272015-1anph6qi 41 31 severe severe JJ cord-272015-1anph6qi 41 32 COVID-19 COVID-19 NNP cord-272015-1anph6qi 41 33 patients patient NNS cord-272015-1anph6qi 41 34 Hydroxychloroquine Hydroxychloroquine NNP cord-272015-1anph6qi 41 35 use use VB cord-272015-1anph6qi 41 36 against against IN cord-272015-1anph6qi 41 37 SARS SARS NNP cord-272015-1anph6qi 41 38 - - HYPH cord-272015-1anph6qi 41 39 CoV-2 CoV-2 NNP cord-272015-1anph6qi 41 40 infection infection NN cord-272015-1anph6qi 41 41 in in IN cord-272015-1anph6qi 41 42 non non JJ cord-272015-1anph6qi 41 43 - - JJ cord-272015-1anph6qi 41 44 human human JJ cord-272015-1anph6qi 41 45 primates primate NNS cord-272015-1anph6qi 41 46 Colchicine Colchicine NNP cord-272015-1anph6qi 41 47 as as IN cord-272015-1anph6qi 41 48 a a DT cord-272015-1anph6qi 41 49 possible possible JJ cord-272015-1anph6qi 41 50 therapeutic therapeutic JJ cord-272015-1anph6qi 41 51 option option NN cord-272015-1anph6qi 41 52 in in IN cord-272015-1anph6qi 41 53 COVID-19 COVID-19 NNP cord-272015-1anph6qi 41 54 infection infection NN cord-272015-1anph6qi 41 55 Selective selective JJ cord-272015-1anph6qi 41 56 regulation regulation NN cord-272015-1anph6qi 41 57 of of IN cord-272015-1anph6qi 41 58 cytokine cytokine JJ cord-272015-1anph6qi 41 59 secretion secretion NN cord-272015-1anph6qi 41 60 by by IN cord-272015-1anph6qi 41 61 hydroxychloroquine hydroxychloroquine NN cord-272015-1anph6qi 41 62 : : : cord-272015-1anph6qi 41 63 inhibition inhibition NN cord-272015-1anph6qi 41 64 of of IN cord-272015-1anph6qi 41 65 interleukin interleukin NN cord-272015-1anph6qi 41 66 1 1 CD cord-272015-1anph6qi 41 67 alpha alpha NN cord-272015-1anph6qi 41 68 ( ( -LRB- cord-272015-1anph6qi 41 69 IL-1-alpha IL-1-alpha '' cord-272015-1anph6qi 41 70 ) ) -RRB- cord-272015-1anph6qi 41 71 and and CC cord-272015-1anph6qi 41 72 IL-6 IL-6 NNP cord-272015-1anph6qi 41 73 in in IN cord-272015-1anph6qi 41 74 human human JJ cord-272015-1anph6qi 41 75 monocytes monocyte NNS cord-272015-1anph6qi 41 76 and and CC cord-272015-1anph6qi 41 77 T t NN cord-272015-1anph6qi 41 78 cells cell NNS cord-272015-1anph6qi 41 79 Effect effect NN cord-272015-1anph6qi 41 80 of of IN cord-272015-1anph6qi 41 81 Hydroxychloroquine Hydroxychloroquine NNP cord-272015-1anph6qi 41 82 in in IN cord-272015-1anph6qi 41 83 Hospitalized Hospitalized NNP cord-272015-1anph6qi 41 84 Patients Patients NNP cord-272015-1anph6qi 41 85 with with IN cord-272015-1anph6qi 41 86 Covid-19 Covid-19 NNP cord-272015-1anph6qi 41 87 Clinical clinical JJ cord-272015-1anph6qi 41 88 criteria criterion NNS cord-272015-1anph6qi 41 89 for for IN cord-272015-1anph6qi 41 90 COVID-19-associated COVID-19-associated NNP cord-272015-1anph6qi 41 91 hyperinflammatory hyperinflammatory NNP cord-272015-1anph6qi 41 92 syndrome syndrome NN cord-272015-1anph6qi 41 93 : : : cord-272015-1anph6qi 41 94 a a DT cord-272015-1anph6qi 41 95 cohort cohort NN cord-272015-1anph6qi 41 96 study study NN cord-272015-1anph6qi 41 97 World World NNP cord-272015-1anph6qi 41 98 Health Health NNP cord-272015-1anph6qi 41 99 Organization Organization NNP cord-272015-1anph6qi 41 100 Extrafollicular Extrafollicular NNP cord-272015-1anph6qi 41 101 B B NNP cord-272015-1anph6qi 41 102 cell cell NN cord-272015-1anph6qi 41 103 responses response NNS cord-272015-1anph6qi 41 104 correlate correlate VBP cord-272015-1anph6qi 41 105 with with IN cord-272015-1anph6qi 41 106 neutralizing neutralize VBG cord-272015-1anph6qi 41 107 antibodies antibody NNS cord-272015-1anph6qi 41 108 and and CC cord-272015-1anph6qi 41 109 morbidity morbidity NN cord-272015-1anph6qi 41 110 in in IN cord-272015-1anph6qi 41 111 COVID-19 COVID-19 NNP