id sid tid token lemma pos cord-270528-3rsv3jlh 1 1 key key JJ cord-270528-3rsv3jlh 1 2 : : : cord-270528-3rsv3jlh 1 3 cord-270528- cord-270528- NN cord-270528-3rsv3jlh 2 1 3rsv3jlh 3rsv3jlh CD cord-270528-3rsv3jlh 2 2 authors author NNS cord-270528-3rsv3jlh 2 3 : : : cord-270528-3rsv3jlh 2 4 Yazdanpanah Yazdanpanah NNP cord-270528-3rsv3jlh 2 5 , , , cord-270528-3rsv3jlh 2 6 Fereshteh Fereshteh NNP cord-270528-3rsv3jlh 2 7 ; ; : cord-270528-3rsv3jlh 2 8 Hamblin Hamblin NNP cord-270528-3rsv3jlh 2 9 , , , cord-270528-3rsv3jlh 2 10 Michael Michael NNP cord-270528-3rsv3jlh 2 11 R. R. NNP cord-270528-3rsv3jlh 2 12 ; ; : cord-270528-3rsv3jlh 2 13 Rezaei Rezaei NNP cord-270528-3rsv3jlh 2 14 , , , cord-270528-3rsv3jlh 2 15 Nima Nima NNP cord-270528-3rsv3jlh 2 16 title title NN cord-270528-3rsv3jlh 2 17 : : : cord-270528-3rsv3jlh 2 18 The the DT cord-270528-3rsv3jlh 2 19 immune immune JJ cord-270528-3rsv3jlh 2 20 system system NN cord-270528-3rsv3jlh 2 21 and and CC cord-270528-3rsv3jlh 2 22 COVID-19 covid-19 NN cord-270528-3rsv3jlh 2 23 : : : cord-270528-3rsv3jlh 2 24 Friend friend NN cord-270528-3rsv3jlh 2 25 or or CC cord-270528-3rsv3jlh 2 26 foe foe NN cord-270528-3rsv3jlh 2 27 ? ? . cord-270528-3rsv3jlh 3 1 date date NN cord-270528-3rsv3jlh 3 2 : : : cord-270528-3rsv3jlh 3 3 2020 2020 CD cord-270528-3rsv3jlh 3 4 - - HYPH cord-270528-3rsv3jlh 3 5 06 06 CD cord-270528-3rsv3jlh 3 6 - - SYM cord-270528-3rsv3jlh 3 7 02 02 CD cord-270528-3rsv3jlh 3 8 journal journal NN cord-270528-3rsv3jlh 3 9 : : : cord-270528-3rsv3jlh 4 1 Life life NN cord-270528-3rsv3jlh 5 1 Sci Sci NNP cord-270528-3rsv3jlh 5 2 DOI DOI NNP cord-270528-3rsv3jlh 5 3 : : : cord-270528-3rsv3jlh 6 1 10.1016 10.1016 CD cord-270528-3rsv3jlh 6 2 / / SYM cord-270528-3rsv3jlh 6 3 j.lfs.2020.117900 j.lfs.2020.117900 NNP cord-270528-3rsv3jlh 6 4 sha sha NNP cord-270528-3rsv3jlh 6 5 : : : cord-270528-3rsv3jlh 6 6 7262604ab9f43f58f89578c77e9252c66caefafe 7262604ab9f43f58f89578c77e9252c66caefafe CD cord-270528-3rsv3jlh 6 7 doc_id doc_id CD cord-270528-3rsv3jlh 6 8 : : : cord-270528-3rsv3jlh 6 9 270528 270528 CD cord-270528-3rsv3jlh 6 10 cord_uid cord_uid NNS cord-270528-3rsv3jlh 6 11 : : : cord-270528-3rsv3jlh 7 1 3rsv3jlh 3rsv3jlh CD cord-270528-3rsv3jlh 7 2 AIM aim VBP cord-270528-3rsv3jlh 7 3 : : : cord-270528-3rsv3jlh 7 4 Coronavirus Coronavirus NNP cord-270528-3rsv3jlh 7 5 disease disease NN cord-270528-3rsv3jlh 7 6 2019 2019 CD cord-270528-3rsv3jlh 8 1 ( ( -LRB- cord-270528-3rsv3jlh 8 2 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 8 3 ) ) -RRB- cord-270528-3rsv3jlh 8 4 is be VBZ cord-270528-3rsv3jlh 8 5 a a DT cord-270528-3rsv3jlh 8 6 novel novel NN cord-270528-3rsv3jlh 8 7 highly highly RB cord-270528-3rsv3jlh 8 8 contagious contagious JJ cord-270528-3rsv3jlh 8 9 infection infection NN cord-270528-3rsv3jlh 8 10 caused cause VBN cord-270528-3rsv3jlh 8 11 by by IN cord-270528-3rsv3jlh 8 12 SARS SARS NNP cord-270528-3rsv3jlh 8 13 - - HYPH cord-270528-3rsv3jlh 8 14 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 8 15 , , , cord-270528-3rsv3jlh 8 16 which which WDT cord-270528-3rsv3jlh 8 17 has have VBZ cord-270528-3rsv3jlh 8 18 been be VBN cord-270528-3rsv3jlh 8 19 became become VBN cord-270528-3rsv3jlh 8 20 a a DT cord-270528-3rsv3jlh 8 21 global global JJ cord-270528-3rsv3jlh 8 22 public public JJ cord-270528-3rsv3jlh 8 23 health health NN cord-270528-3rsv3jlh 8 24 challenge challenge NN cord-270528-3rsv3jlh 8 25 . . . cord-270528-3rsv3jlh 9 1 The the DT cord-270528-3rsv3jlh 9 2 pathogenesis pathogenesis NN cord-270528-3rsv3jlh 9 3 of of IN cord-270528-3rsv3jlh 9 4 this this DT cord-270528-3rsv3jlh 9 5 virus virus NN cord-270528-3rsv3jlh 9 6 is be VBZ cord-270528-3rsv3jlh 9 7 not not RB cord-270528-3rsv3jlh 9 8 yet yet RB cord-270528-3rsv3jlh 9 9 clearly clearly RB cord-270528-3rsv3jlh 9 10 understood understand VBN cord-270528-3rsv3jlh 9 11 , , , cord-270528-3rsv3jlh 9 12 but but CC cord-270528-3rsv3jlh 9 13 there there EX cord-270528-3rsv3jlh 9 14 is be VBZ cord-270528-3rsv3jlh 9 15 evidence evidence NN cord-270528-3rsv3jlh 9 16 of of IN cord-270528-3rsv3jlh 9 17 a a DT cord-270528-3rsv3jlh 9 18 hyper hyper JJ cord-270528-3rsv3jlh 9 19 - - JJ cord-270528-3rsv3jlh 9 20 inflammatory inflammatory JJ cord-270528-3rsv3jlh 9 21 immune immune JJ cord-270528-3rsv3jlh 9 22 response response NN cord-270528-3rsv3jlh 9 23 in in IN cord-270528-3rsv3jlh 9 24 critically critically RB cord-270528-3rsv3jlh 9 25 ill ill JJ cord-270528-3rsv3jlh 9 26 patients patient NNS cord-270528-3rsv3jlh 9 27 , , , cord-270528-3rsv3jlh 9 28 which which WDT cord-270528-3rsv3jlh 9 29 leads lead VBZ cord-270528-3rsv3jlh 9 30 to to IN cord-270528-3rsv3jlh 9 31 acute acute JJ cord-270528-3rsv3jlh 9 32 respiratory respiratory JJ cord-270528-3rsv3jlh 9 33 distress distress NN cord-270528-3rsv3jlh 9 34 syndrome syndrome NN cord-270528-3rsv3jlh 9 35 ( ( -LRB- cord-270528-3rsv3jlh 9 36 ARDS ARDS NNP cord-270528-3rsv3jlh 9 37 ) ) -RRB- cord-270528-3rsv3jlh 9 38 and and CC cord-270528-3rsv3jlh 9 39 multi multi JJ cord-270528-3rsv3jlh 9 40 - - JJ cord-270528-3rsv3jlh 9 41 organ organ JJ cord-270528-3rsv3jlh 9 42 failure failure NN cord-270528-3rsv3jlh 9 43 . . . cord-270528-3rsv3jlh 10 1 MATERIAL material NN cord-270528-3rsv3jlh 10 2 AND and CC cord-270528-3rsv3jlh 10 3 METHODS method NNS cord-270528-3rsv3jlh 10 4 : : : cord-270528-3rsv3jlh 11 1 A a DT cord-270528-3rsv3jlh 11 2 literature literature NN cord-270528-3rsv3jlh 11 3 review review NN cord-270528-3rsv3jlh 11 4 was be VBD cord-270528-3rsv3jlh 11 5 performed perform VBN cord-270528-3rsv3jlh 11 6 to to TO cord-270528-3rsv3jlh 11 7 identify identify VB cord-270528-3rsv3jlh 11 8 relevant relevant JJ cord-270528-3rsv3jlh 11 9 articles article NNS cord-270528-3rsv3jlh 11 10 on on IN cord-270528-3rsv3jlh 11 11 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 11 12 published publish VBN cord-270528-3rsv3jlh 11 13 up up RP cord-270528-3rsv3jlh 11 14 to to IN cord-270528-3rsv3jlh 11 15 April April NNP cord-270528-3rsv3jlh 11 16 30 30 CD cord-270528-3rsv3jlh 11 17 , , , cord-270528-3rsv3jlh 11 18 2020 2020 CD cord-270528-3rsv3jlh 11 19 . . . cord-270528-3rsv3jlh 12 1 The the DT cord-270528-3rsv3jlh 12 2 search search NN cord-270528-3rsv3jlh 12 3 resulted result VBD cord-270528-3rsv3jlh 12 4 in in IN cord-270528-3rsv3jlh 12 5 361 361 CD cord-270528-3rsv3jlh 12 6 total total JJ cord-270528-3rsv3jlh 12 7 articles article NNS cord-270528-3rsv3jlh 12 8 . . . cord-270528-3rsv3jlh 13 1 After after IN cord-270528-3rsv3jlh 13 2 reviewing review VBG cord-270528-3rsv3jlh 13 3 the the DT cord-270528-3rsv3jlh 13 4 titles title NNS cord-270528-3rsv3jlh 13 5 and and CC cord-270528-3rsv3jlh 13 6 abstracts abstract NNS cord-270528-3rsv3jlh 13 7 for for IN cord-270528-3rsv3jlh 13 8 inclusion inclusion NN cord-270528-3rsv3jlh 13 9 , , , cord-270528-3rsv3jlh 13 10 some some DT cord-270528-3rsv3jlh 13 11 irrelevant irrelevant JJ cord-270528-3rsv3jlh 13 12 papers paper NNS cord-270528-3rsv3jlh 13 13 were be VBD cord-270528-3rsv3jlh 13 14 excluded exclude VBN cord-270528-3rsv3jlh 13 15 . . . cord-270528-3rsv3jlh 14 1 Additional additional JJ cord-270528-3rsv3jlh 14 2 relevant relevant JJ cord-270528-3rsv3jlh 14 3 articles article NNS cord-270528-3rsv3jlh 14 4 were be VBD cord-270528-3rsv3jlh 14 5 identified identify VBN cord-270528-3rsv3jlh 14 6 from from IN cord-270528-3rsv3jlh 14 7 a a DT cord-270528-3rsv3jlh 14 8 review review NN cord-270528-3rsv3jlh 14 9 of of IN cord-270528-3rsv3jlh 14 10 citations citation NNS cord-270528-3rsv3jlh 14 11 referenced reference VBN cord-270528-3rsv3jlh 14 12 . . . cord-270528-3rsv3jlh 15 1 KEY KEY NNP cord-270528-3rsv3jlh 15 2 FINDINGS FINDINGS NNP cord-270528-3rsv3jlh 15 3 : : : cord-270528-3rsv3jlh 16 1 SARS SARS NNP cord-270528-3rsv3jlh 16 2 - - HYPH cord-270528-3rsv3jlh 16 3 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 16 4 , , , cord-270528-3rsv3jlh 16 5 directly directly RB cord-270528-3rsv3jlh 16 6 and and CC cord-270528-3rsv3jlh 16 7 indirectly indirectly RB cord-270528-3rsv3jlh 16 8 , , , cord-270528-3rsv3jlh 16 9 affects affect VBZ cord-270528-3rsv3jlh 16 10 the the DT cord-270528-3rsv3jlh 16 11 immune immune JJ cord-270528-3rsv3jlh 16 12 system system NN cord-270528-3rsv3jlh 16 13 and and CC cord-270528-3rsv3jlh 16 14 avoids avoid VBZ cord-270528-3rsv3jlh 16 15 being be VBG cord-270528-3rsv3jlh 16 16 eliminated eliminate VBN cord-270528-3rsv3jlh 16 17 in in IN cord-270528-3rsv3jlh 16 18 early early JJ cord-270528-3rsv3jlh 16 19 stages stage NNS cord-270528-3rsv3jlh 16 20 . . . cord-270528-3rsv3jlh 17 1 On on IN cord-270528-3rsv3jlh 17 2 the the DT cord-270528-3rsv3jlh 17 3 other other JJ cord-270528-3rsv3jlh 17 4 hand hand NN cord-270528-3rsv3jlh 17 5 , , , cord-270528-3rsv3jlh 17 6 the the DT cord-270528-3rsv3jlh 17 7 secretion secretion NN cord-270528-3rsv3jlh 17 8 of of IN cord-270528-3rsv3jlh 17 9 inflammatory inflammatory JJ cord-270528-3rsv3jlh 17 10 cytokines cytokine NNS cord-270528-3rsv3jlh 17 11 creates create VBZ cord-270528-3rsv3jlh 17 12 critical critical JJ cord-270528-3rsv3jlh 17 13 conditions condition NNS cord-270528-3rsv3jlh 17 14 that that WDT cord-270528-3rsv3jlh 17 15 lead lead VBP cord-270528-3rsv3jlh 17 16 to to IN cord-270528-3rsv3jlh 17 17 multi multi JJ cord-270528-3rsv3jlh 17 18 - - JJ cord-270528-3rsv3jlh 17 19 organ organ JJ cord-270528-3rsv3jlh 17 20 failure failure NN cord-270528-3rsv3jlh 17 21 . . . cord-270528-3rsv3jlh 18 1 SIGNIFICANCE significance NN cord-270528-3rsv3jlh 18 2 : : : cord-270528-3rsv3jlh 19 1 The the DT cord-270528-3rsv3jlh 19 2 immune immune JJ cord-270528-3rsv3jlh 19 3 system system NN cord-270528-3rsv3jlh 19 4 which which WDT cord-270528-3rsv3jlh 19 5 is be VBZ cord-270528-3rsv3jlh 19 6 affected affect VBN cord-270528-3rsv3jlh 19 7 by by IN cord-270528-3rsv3jlh 19 8 the the DT cord-270528-3rsv3jlh 19 9 virus virus NN cord-270528-3rsv3jlh 19 10 tries try VBZ cord-270528-3rsv3jlh 19 11 to to TO cord-270528-3rsv3jlh 19 12 respond respond VB cord-270528-3rsv3jlh 19 13 via via IN cord-270528-3rsv3jlh 19 14 a a DT cord-270528-3rsv3jlh 19 15 cytokine cytokine NN cord-270528-3rsv3jlh 19 16 storm storm NN cord-270528-3rsv3jlh 19 17 and and CC cord-270528-3rsv3jlh 19 18 hyperinflammation hyperinflammation NN cord-270528-3rsv3jlh 19 19 , , , cord-270528-3rsv3jlh 19 20 which which WDT cord-270528-3rsv3jlh 19 21 itself -PRON- PRP cord-270528-3rsv3jlh 19 22 leads lead VBZ cord-270528-3rsv3jlh 19 23 to to IN cord-270528-3rsv3jlh 19 24 further further JJ cord-270528-3rsv3jlh 19 25 multi multi JJ cord-270528-3rsv3jlh 19 26 - - JJ cord-270528-3rsv3jlh 19 27 organ organ JJ cord-270528-3rsv3jlh 19 28 damage damage NN cord-270528-3rsv3jlh 19 29 and and CC cord-270528-3rsv3jlh 19 30 even even RB cord-270528-3rsv3jlh 19 31 death death NN cord-270528-3rsv3jlh 19 32 . . . cord-270528-3rsv3jlh 20 1 Severe severe JJ cord-270528-3rsv3jlh 20 2 acute acute JJ cord-270528-3rsv3jlh 20 3 respiratory respiratory JJ cord-270528-3rsv3jlh 20 4 syndrome syndrome NN cord-270528-3rsv3jlh 20 5 coronavirus coronavirus NN cord-270528-3rsv3jlh 20 6 2 2 CD cord-270528-3rsv3jlh 21 1 ( ( -LRB- cord-270528-3rsv3jlh 21 2 SARS SARS NNP cord-270528-3rsv3jlh 21 3 - - HYPH cord-270528-3rsv3jlh 21 4 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 21 5 ) ) -RRB- cord-270528-3rsv3jlh 21 6 causes cause VBZ cord-270528-3rsv3jlh 21 7 the the DT cord-270528-3rsv3jlh 21 8 coronavirus coronavirus NN cord-270528-3rsv3jlh 21 9 disease disease NN cord-270528-3rsv3jlh 21 10 2019 2019 CD cord-270528-3rsv3jlh 21 11 ( ( -LRB- cord-270528-3rsv3jlh 21 12 COVID- COVID- NNP cord-270528-3rsv3jlh 21 13 19 19 CD cord-270528-3rsv3jlh 21 14 ) ) -RRB- cord-270528-3rsv3jlh 21 15 , , , cord-270528-3rsv3jlh 21 16 and and CC cord-270528-3rsv3jlh 21 17 has have VBZ cord-270528-3rsv3jlh 21 18 affected affect VBN cord-270528-3rsv3jlh 21 19 people people NNS cord-270528-3rsv3jlh 21 20 's 's POS cord-270528-3rsv3jlh 21 21 lives life NNS cord-270528-3rsv3jlh 21 22 globally globally RB cord-270528-3rsv3jlh 21 23 , , , cord-270528-3rsv3jlh 21 24 since since IN cord-270528-3rsv3jlh 21 25 first first RB cord-270528-3rsv3jlh 21 26 observed observe VBD cord-270528-3rsv3jlh 21 27 in in IN cord-270528-3rsv3jlh 21 28 Wuhan Wuhan NNP cord-270528-3rsv3jlh 21 29 , , , cord-270528-3rsv3jlh 21 30 China China NNP cord-270528-3rsv3jlh 21 31 in in IN cord-270528-3rsv3jlh 21 32 the the DT cord-270528-3rsv3jlh 21 33 last last JJ cord-270528-3rsv3jlh 21 34 days day NNS cord-270528-3rsv3jlh 21 35 of of IN cord-270528-3rsv3jlh 21 36 2019 2019 CD cord-270528-3rsv3jlh 21 37 ( ( -LRB- cord-270528-3rsv3jlh 21 38 1 1 CD cord-270528-3rsv3jlh 21 39 , , , cord-270528-3rsv3jlh 21 40 2 2 CD cord-270528-3rsv3jlh 21 41 ) ) -RRB- cord-270528-3rsv3jlh 21 42 . . . cord-270528-3rsv3jlh 22 1 The the DT cord-270528-3rsv3jlh 22 2 main main JJ cord-270528-3rsv3jlh 22 3 route route NN cord-270528-3rsv3jlh 22 4 of of IN cord-270528-3rsv3jlh 22 5 virus virus NN cord-270528-3rsv3jlh 22 6 entry entry NN cord-270528-3rsv3jlh 22 7 and and CC cord-270528-3rsv3jlh 22 8 transmission transmission NN cord-270528-3rsv3jlh 22 9 is be VBZ cord-270528-3rsv3jlh 22 10 respiratory respiratory JJ cord-270528-3rsv3jlh 22 11 droplets droplet NNS cord-270528-3rsv3jlh 22 12 that that WDT cord-270528-3rsv3jlh 22 13 are be VBP cord-270528-3rsv3jlh 22 14 expelled expel VBN cord-270528-3rsv3jlh 22 15 and and CC cord-270528-3rsv3jlh 22 16 absorbed absorb VBN cord-270528-3rsv3jlh 22 17 by by IN cord-270528-3rsv3jlh 22 18 the the DT cord-270528-3rsv3jlh 22 19 mucous mucous JJ cord-270528-3rsv3jlh 22 20 membranes membrane NNS cord-270528-3rsv3jlh 22 21 , , , cord-270528-3rsv3jlh 22 22 especially especially RB cord-270528-3rsv3jlh 22 23 the the DT cord-270528-3rsv3jlh 22 24 nasal nasal NN cord-270528-3rsv3jlh 22 25 and and CC cord-270528-3rsv3jlh 22 26 larynx larynx NN cord-270528-3rsv3jlh 22 27 mucosa mucosa JJ cord-270528-3rsv3jlh 22 28 . . . cord-270528-3rsv3jlh 23 1 COVID-19 covid-19 JJ cord-270528-3rsv3jlh 23 2 spreads spread NNS cord-270528-3rsv3jlh 23 3 readily readily RB cord-270528-3rsv3jlh 23 4 via via IN cord-270528-3rsv3jlh 23 5 person person NN cord-270528-3rsv3jlh 23 6 - - HYPH cord-270528-3rsv3jlh 23 7 to to IN cord-270528-3rsv3jlh 23 8 - - HYPH cord-270528-3rsv3jlh 23 9 person person NN cord-270528-3rsv3jlh 23 10 contact contact NN cord-270528-3rsv3jlh 23 11 ( ( -LRB- cord-270528-3rsv3jlh 23 12 3 3 CD cord-270528-3rsv3jlh 23 13 ) ) -RRB- cord-270528-3rsv3jlh 23 14 . . . cord-270528-3rsv3jlh 24 1 The the DT cord-270528-3rsv3jlh 24 2 clinical clinical JJ cord-270528-3rsv3jlh 24 3 spectrum spectrum NN cord-270528-3rsv3jlh 24 4 of of IN cord-270528-3rsv3jlh 24 5 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 24 6 varies vary VBZ cord-270528-3rsv3jlh 24 7 from from IN cord-270528-3rsv3jlh 24 8 an an DT cord-270528-3rsv3jlh 24 9 asymptomatic asymptomatic JJ cord-270528-3rsv3jlh 24 10 form form NN cord-270528-3rsv3jlh 24 11 to to IN cord-270528-3rsv3jlh 24 12 severe severe JJ cord-270528-3rsv3jlh 24 13 respiratory respiratory JJ cord-270528-3rsv3jlh 24 14 failure failure NN cord-270528-3rsv3jlh 24 15 ( ( -LRB- cord-270528-3rsv3jlh 24 16 SRF SRF NNP cord-270528-3rsv3jlh 24 17 ) ) -RRB- cord-270528-3rsv3jlh 24 18 that that WDT cord-270528-3rsv3jlh 24 19 necessitates necessitate VBZ cord-270528-3rsv3jlh 24 20 mechanical mechanical JJ cord-270528-3rsv3jlh 24 21 ventilation ventilation NN cord-270528-3rsv3jlh 24 22 and and CC cord-270528-3rsv3jlh 24 23 support support NN cord-270528-3rsv3jlh 24 24 in in IN cord-270528-3rsv3jlh 24 25 an an DT cord-270528-3rsv3jlh 24 26 intensive intensive JJ cord-270528-3rsv3jlh 24 27 care care NN cord-270528-3rsv3jlh 24 28 unit unit NN cord-270528-3rsv3jlh 24 29 ( ( -LRB- cord-270528-3rsv3jlh 24 30 ICU ICU NNP cord-270528-3rsv3jlh 24 31 ) ) -RRB- cord-270528-3rsv3jlh 24 32 and and CC cord-270528-3rsv3jlh 24 33 can can MD cord-270528-3rsv3jlh 24 34 lead lead VB cord-270528-3rsv3jlh 24 35 to to IN cord-270528-3rsv3jlh 24 36 multi multi JJ cord-270528-3rsv3jlh 24 37 - - JJ cord-270528-3rsv3jlh 24 38 organ organ JJ cord-270528-3rsv3jlh 24 39 failure failure NN cord-270528-3rsv3jlh 24 40 . . . cord-270528-3rsv3jlh 25 1 Pneumonia pneumonia NN cord-270528-3rsv3jlh 25 2 is be VBZ cord-270528-3rsv3jlh 25 3 the the DT cord-270528-3rsv3jlh 25 4 most most RBS cord-270528-3rsv3jlh 25 5 frequent frequent JJ cord-270528-3rsv3jlh 25 6 serious serious JJ cord-270528-3rsv3jlh 25 7 manifestation manifestation NN cord-270528-3rsv3jlh 25 8 of of IN cord-270528-3rsv3jlh 25 9 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 25 10 , , , cord-270528-3rsv3jlh 25 11 characterized characterize VBN cord-270528-3rsv3jlh 25 12 primarily primarily RB cord-270528-3rsv3jlh 25 13 by by IN cord-270528-3rsv3jlh 25 14 fever fever NN cord-270528-3rsv3jlh 25 15 , , , cord-270528-3rsv3jlh 25 16 dry dry JJ cord-270528-3rsv3jlh 25 17 cough cough NN cord-270528-3rsv3jlh 25 18 , , , cord-270528-3rsv3jlh 25 19 and and CC cord-270528-3rsv3jlh 25 20 dyspnea dyspnea NN cord-270528-3rsv3jlh 25 21 . . . cord-270528-3rsv3jlh 26 1 Other other JJ cord-270528-3rsv3jlh 26 2 less less JJR cord-270528-3rsv3jlh 26 3 common common JJ cord-270528-3rsv3jlh 26 4 symptoms symptom NNS cord-270528-3rsv3jlh 26 5 are be VBP cord-270528-3rsv3jlh 26 6 headaches headache NNS cord-270528-3rsv3jlh 26 7 , , , cord-270528-3rsv3jlh 26 8 sore sore JJ cord-270528-3rsv3jlh 26 9 throat throat NN cord-270528-3rsv3jlh 26 10 , , , cord-270528-3rsv3jlh 26 11 and and CC cord-270528-3rsv3jlh 26 12 rhinorrhea rhinorrhea NNP cord-270528-3rsv3jlh 26 13 . . . cord-270528-3rsv3jlh 27 1 In in IN cord-270528-3rsv3jlh 27 2 addition addition NN cord-270528-3rsv3jlh 27 3 to to IN cord-270528-3rsv3jlh 27 4 respiratory respiratory JJ cord-270528-3rsv3jlh 27 5 symptoms symptom NNS cord-270528-3rsv3jlh 27 6 , , , cord-270528-3rsv3jlh 27 7 gastrointestinal gastrointestinal JJ cord-270528-3rsv3jlh 27 8 symptoms symptom NNS cord-270528-3rsv3jlh 27 9 , , , cord-270528-3rsv3jlh 27 10 myalgia myalgia NN cord-270528-3rsv3jlh 27 11 , , , cord-270528-3rsv3jlh 27 12 skin skin NN cord-270528-3rsv3jlh 27 13 rashes rash NNS cord-270528-3rsv3jlh 27 14 , , , cord-270528-3rsv3jlh 27 15 and and CC cord-270528-3rsv3jlh 27 16 neurological neurological JJ cord-270528-3rsv3jlh 27 17 involvement involvement NN cord-270528-3rsv3jlh 27 18 have have VBP cord-270528-3rsv3jlh 27 19 also also RB cord-270528-3rsv3jlh 27 20 been be VBN cord-270528-3rsv3jlh 27 21 reported report VBN cord-270528-3rsv3jlh 27 22 ( ( -LRB- cord-270528-3rsv3jlh 27 23 1 1 CD cord-270528-3rsv3jlh 27 24 , , , cord-270528-3rsv3jlh 27 25 3 3 CD cord-270528-3rsv3jlh 27 26 - - SYM cord-270528-3rsv3jlh 27 27 6 6 CD cord-270528-3rsv3jlh 27 28 ) ) -RRB- cord-270528-3rsv3jlh 27 29 . . . cord-270528-3rsv3jlh 28 1 SARS SARS NNP cord-270528-3rsv3jlh 28 2 - - HYPH cord-270528-3rsv3jlh 28 3 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 28 4 belongs belong VBZ cord-270528-3rsv3jlh 28 5 to to IN cord-270528-3rsv3jlh 28 6 the the DT cord-270528-3rsv3jlh 28 7 coronavirus coronavirus NN cord-270528-3rsv3jlh 28 8 family family NN cord-270528-3rsv3jlh 28 9 , , , cord-270528-3rsv3jlh 28 10 members member NNS cord-270528-3rsv3jlh 28 11 of of IN cord-270528-3rsv3jlh 28 12 which which WDT cord-270528-3rsv3jlh 28 13 have have VBP cord-270528-3rsv3jlh 28 14 caused cause VBN cord-270528-3rsv3jlh 28 15 two two CD cord-270528-3rsv3jlh 28 16 previous previous JJ cord-270528-3rsv3jlh 28 17 epidemics epidemic NNS cord-270528-3rsv3jlh 28 18 at at IN cord-270528-3rsv3jlh 28 19 the the DT cord-270528-3rsv3jlh 28 20 beginning beginning NN cord-270528-3rsv3jlh 28 21 of of IN cord-270528-3rsv3jlh 28 22 the the DT cord-270528-3rsv3jlh 28 23 21st 21st JJ cord-270528-3rsv3jlh 28 24 century century NN cord-270528-3rsv3jlh 28 25 ; ; : cord-270528-3rsv3jlh 28 26 one one CD cord-270528-3rsv3jlh 28 27 named name VBN cord-270528-3rsv3jlh 28 28 SARS SARS NNP cord-270528-3rsv3jlh 28 29 - - HYPH cord-270528-3rsv3jlh 28 30 CoV CoV NNP cord-270528-3rsv3jlh 28 31 and and CC cord-270528-3rsv3jlh 28 32 the the DT cord-270528-3rsv3jlh 28 33 other other JJ cord-270528-3rsv3jlh 28 34 Middle Middle NNP cord-270528-3rsv3jlh 28 35 East East NNP cord-270528-3rsv3jlh 28 36 Respiratory Respiratory NNP cord-270528-3rsv3jlh 28 37 Syndrome Syndrome NNP cord-270528-3rsv3jlh 28 38 ( ( -LRB- cord-270528-3rsv3jlh 28 39 MERS MERS NNP cord-270528-3rsv3jlh 28 40 ) ) -RRB- cord-270528-3rsv3jlh 28 41 . . . cord-270528-3rsv3jlh 29 1 Coronaviruses coronaviruse NNS cord-270528-3rsv3jlh 29 2 are be VBP cord-270528-3rsv3jlh 29 3 large large JJ cord-270528-3rsv3jlh 29 4 enveloped envelop VBN cord-270528-3rsv3jlh 29 5 viruses virus NNS cord-270528-3rsv3jlh 29 6 with with IN cord-270528-3rsv3jlh 29 7 a a DT cord-270528-3rsv3jlh 29 8 positive positive JJ cord-270528-3rsv3jlh 29 9 sense sense NN cord-270528-3rsv3jlh 29 10 RNA RNA NNP cord-270528-3rsv3jlh 29 11 genome genome NN cord-270528-3rsv3jlh 29 12 . . . cord-270528-3rsv3jlh 30 1 The the DT cord-270528-3rsv3jlh 30 2 lipid lipid NN cord-270528-3rsv3jlh 30 3 bilayer bilayer NN cord-270528-3rsv3jlh 30 4 envelope envelope NN cord-270528-3rsv3jlh 30 5 of of IN cord-270528-3rsv3jlh 30 6 the the DT cord-270528-3rsv3jlh 30 7 virus virus NN cord-270528-3rsv3jlh 30 8 contains contain VBZ cord-270528-3rsv3jlh 30 9 several several JJ cord-270528-3rsv3jlh 30 10 proteins protein NNS cord-270528-3rsv3jlh 30 11 with with IN cord-270528-3rsv3jlh 30 12 different different JJ cord-270528-3rsv3jlh 30 13 tasks task NNS cord-270528-3rsv3jlh 30 14 . . . cord-270528-3rsv3jlh 31 1 The the DT cord-270528-3rsv3jlh 31 2 spike spike NN cord-270528-3rsv3jlh 31 3 or or CC cord-270528-3rsv3jlh 31 4 S s NN cord-270528-3rsv3jlh 31 5 glycoprotein glycoprotein NN cord-270528-3rsv3jlh 31 6 , , , cord-270528-3rsv3jlh 31 7 has have VBZ cord-270528-3rsv3jlh 31 8 two two CD cord-270528-3rsv3jlh 31 9 domains domain NNS cord-270528-3rsv3jlh 31 10 of of IN cord-270528-3rsv3jlh 31 11 S1 s1 NN cord-270528-3rsv3jlh 31 12 and and CC cord-270528-3rsv3jlh 31 13 S2 S2 NNP cord-270528-3rsv3jlh 31 14 , , , cord-270528-3rsv3jlh 31 15 is be VBZ cord-270528-3rsv3jlh 31 16 responsible responsible JJ cord-270528-3rsv3jlh 31 17 for for IN cord-270528-3rsv3jlh 31 18 invasion invasion NN cord-270528-3rsv3jlh 31 19 , , , cord-270528-3rsv3jlh 31 20 attachment attachment NN cord-270528-3rsv3jlh 31 21 , , , cord-270528-3rsv3jlh 31 22 and and CC cord-270528-3rsv3jlh 31 23 entry entry NN cord-270528-3rsv3jlh 31 24 into into IN cord-270528-3rsv3jlh 31 25 human human JJ cord-270528-3rsv3jlh 31 26 cells cell NNS cord-270528-3rsv3jlh 31 27 . . . cord-270528-3rsv3jlh 32 1 The the DT cord-270528-3rsv3jlh 32 2 receptor receptor NN cord-270528-3rsv3jlh 32 3 - - HYPH cord-270528-3rsv3jlh 32 4 binding bind VBG cord-270528-3rsv3jlh 32 5 domain domain NN cord-270528-3rsv3jlh 32 6 ( ( -LRB- cord-270528-3rsv3jlh 32 7 RBD RBD NNP cord-270528-3rsv3jlh 32 8 ) ) -RRB- cord-270528-3rsv3jlh 32 9 in in IN cord-270528-3rsv3jlh 32 10 S1 S1 NNP cord-270528-3rsv3jlh 32 11 interacts interact VBZ cord-270528-3rsv3jlh 32 12 with with IN cord-270528-3rsv3jlh 32 13 angiotensin angiotensin NN cord-270528-3rsv3jlh 32 14 - - HYPH cord-270528-3rsv3jlh 32 15 converting convert VBG cord-270528-3rsv3jlh 32 16 enzyme enzyme NN cord-270528-3rsv3jlh 32 17 2 2 CD cord-270528-3rsv3jlh 32 18 ( ( -LRB- cord-270528-3rsv3jlh 32 19 ACE2 ACE2 NNP cord-270528-3rsv3jlh 32 20 ) ) -RRB- cord-270528-3rsv3jlh 32 21 on on IN cord-270528-3rsv3jlh 32 22 the the DT cord-270528-3rsv3jlh 32 23 human human JJ cord-270528-3rsv3jlh 32 24 host host NN cord-270528-3rsv3jlh 32 25 cell cell NN cord-270528-3rsv3jlh 32 26 surface surface NN cord-270528-3rsv3jlh 32 27 , , , cord-270528-3rsv3jlh 32 28 which which WDT cord-270528-3rsv3jlh 32 29 is be VBZ cord-270528-3rsv3jlh 32 30 J J NNP cord-270528-3rsv3jlh 32 31 o o NNP cord-270528-3rsv3jlh 32 32 u u NN cord-270528-3rsv3jlh 32 33 r r NN cord-270528-3rsv3jlh 32 34 n n NN cord-270528-3rsv3jlh 32 35 a a DT cord-270528-3rsv3jlh 32 36 l l NN cord-270528-3rsv3jlh 32 37 P p NN cord-270528-3rsv3jlh 32 38 r r NN cord-270528-3rsv3jlh 32 39 e e NN cord-270528-3rsv3jlh 32 40 -p -p NN cord-270528-3rsv3jlh 33 1 r r NN cord-270528-3rsv3jlh 33 2 o o NN cord-270528-3rsv3jlh 33 3 o o NN cord-270528-3rsv3jlh 33 4 f f NN cord-270528-3rsv3jlh 33 5 4 4 CD cord-270528-3rsv3jlh 33 6 a a DT cord-270528-3rsv3jlh 33 7 similar similar JJ cord-270528-3rsv3jlh 33 8 entry entry NN cord-270528-3rsv3jlh 33 9 mechanism mechanism NN cord-270528-3rsv3jlh 33 10 to to IN cord-270528-3rsv3jlh 33 11 SARS SARS NNP cord-270528-3rsv3jlh 33 12 - - HYPH cord-270528-3rsv3jlh 33 13 CoV CoV NNP cord-270528-3rsv3jlh 34 1 ; ; : cord-270528-3rsv3jlh 34 2 however however RB cord-270528-3rsv3jlh 34 3 , , , cord-270528-3rsv3jlh 34 4 the the DT cord-270528-3rsv3jlh 34 5 S2 S2 NNP cord-270528-3rsv3jlh 34 6 domain domain NN cord-270528-3rsv3jlh 34 7 is be VBZ cord-270528-3rsv3jlh 34 8 responsible responsible JJ cord-270528-3rsv3jlh 34 9 for for IN cord-270528-3rsv3jlh 34 10 virus virus NN cord-270528-3rsv3jlh 34 11 - - HYPH cord-270528-3rsv3jlh 34 12 cell cell NN cord-270528-3rsv3jlh 34 13 membrane membrane NN cord-270528-3rsv3jlh 34 14 fusion fusion NN cord-270528-3rsv3jlh 34 15 and and CC cord-270528-3rsv3jlh 34 16 viral viral JJ cord-270528-3rsv3jlh 34 17 entry entry NN cord-270528-3rsv3jlh 34 18 with with IN cord-270528-3rsv3jlh 34 19 higher high JJR cord-270528-3rsv3jlh 34 20 affinity affinity NN cord-270528-3rsv3jlh 34 21 ( ( -LRB- cord-270528-3rsv3jlh 34 22 7 7 CD cord-270528-3rsv3jlh 34 23 ) ) -RRB- cord-270528-3rsv3jlh 34 24 . . . cord-270528-3rsv3jlh 35 1 Higher high JJR cord-270528-3rsv3jlh 35 2 expression expression NN cord-270528-3rsv3jlh 35 3 of of IN cord-270528-3rsv3jlh 35 4 the the DT cord-270528-3rsv3jlh 35 5 ACE2 ACE2 NNP cord-270528-3rsv3jlh 35 6 receptor receptor NN cord-270528-3rsv3jlh 35 7 in in IN cord-270528-3rsv3jlh 35 8 adults adult NNS cord-270528-3rsv3jlh 35 9 compared compare VBN cord-270528-3rsv3jlh 35 10 to to IN cord-270528-3rsv3jlh 35 11 children child NNS cord-270528-3rsv3jlh 35 12 may may MD cord-270528-3rsv3jlh 35 13 be be VB cord-270528-3rsv3jlh 35 14 a a DT cord-270528-3rsv3jlh 35 15 reason reason NN cord-270528-3rsv3jlh 35 16 for for IN cord-270528-3rsv3jlh 35 17 the the DT cord-270528-3rsv3jlh 35 18 higher high JJR cord-270528-3rsv3jlh 35 19 infection infection NN cord-270528-3rsv3jlh 35 20 rate rate NN cord-270528-3rsv3jlh 35 21 seen see VBN cord-270528-3rsv3jlh 35 22 in in IN cord-270528-3rsv3jlh 35 23 adults adult NNS cord-270528-3rsv3jlh 35 24 ( ( -LRB- cord-270528-3rsv3jlh 35 25 8 8 CD cord-270528-3rsv3jlh 35 26 , , , cord-270528-3rsv3jlh 35 27 9 9 CD cord-270528-3rsv3jlh 35 28 ) ) -RRB- cord-270528-3rsv3jlh 35 29 . . . cord-270528-3rsv3jlh 36 1 Another another DT cord-270528-3rsv3jlh 36 2 noteworthy noteworthy JJ cord-270528-3rsv3jlh 36 3 point point NN cord-270528-3rsv3jlh 36 4 is be VBZ cord-270528-3rsv3jlh 36 5 the the DT cord-270528-3rsv3jlh 36 6 increased increased JJ cord-270528-3rsv3jlh 36 7 level level NN cord-270528-3rsv3jlh 36 8 of of IN cord-270528-3rsv3jlh 36 9 enzymes enzyme NNS cord-270528-3rsv3jlh 36 10 in in IN cord-270528-3rsv3jlh 36 11 the the DT cord-270528-3rsv3jlh 36 12 liver liver NN cord-270528-3rsv3jlh 36 13 , , , cord-270528-3rsv3jlh 36 14 heart heart NN cord-270528-3rsv3jlh 36 15 , , , cord-270528-3rsv3jlh 36 16 and and CC cord-270528-3rsv3jlh 36 17 kidneys kidney NNS cord-270528-3rsv3jlh 36 18 in in IN cord-270528-3rsv3jlh 36 19 COVID-19 covid-19 JJ cord-270528-3rsv3jlh 36 20 patients patient NNS cord-270528-3rsv3jlh 36 21 with with IN cord-270528-3rsv3jlh 36 22 pneumonia pneumonia NN cord-270528-3rsv3jlh 36 23 , , , cord-270528-3rsv3jlh 36 24 which which WDT cord-270528-3rsv3jlh 36 25 is be VBZ cord-270528-3rsv3jlh 36 26 consistent consistent JJ cord-270528-3rsv3jlh 36 27 with with IN cord-270528-3rsv3jlh 36 28 the the DT cord-270528-3rsv3jlh 36 29 tissue tissue NN cord-270528-3rsv3jlh 36 30 expression expression NN cord-270528-3rsv3jlh 36 31 profile profile NN cord-270528-3rsv3jlh 36 32 of of IN cord-270528-3rsv3jlh 36 33 the the DT cord-270528-3rsv3jlh 36 34 ACE2 ACE2 NNP cord-270528-3rsv3jlh 36 35 receptor receptor NN cord-270528-3rsv3jlh 36 36 ( ( -LRB- cord-270528-3rsv3jlh 36 37 10 10 CD cord-270528-3rsv3jlh 36 38 ) ) -RRB- cord-270528-3rsv3jlh 36 39 ; ; : cord-270528-3rsv3jlh 36 40 this this DT cord-270528-3rsv3jlh 36 41 could could MD cord-270528-3rsv3jlh 36 42 also also RB cord-270528-3rsv3jlh 36 43 explain explain VB cord-270528-3rsv3jlh 36 44 the the DT cord-270528-3rsv3jlh 36 45 occurrence occurrence NN cord-270528-3rsv3jlh 36 46 of of IN cord-270528-3rsv3jlh 36 47 multi multi JJ cord-270528-3rsv3jlh 36 48 - - JJ cord-270528-3rsv3jlh 36 49 organ organ JJ cord-270528-3rsv3jlh 36 50 failure failure NN cord-270528-3rsv3jlh 36 51 in in IN cord-270528-3rsv3jlh 36 52 some some DT cord-270528-3rsv3jlh 36 53 patients patient NNS cord-270528-3rsv3jlh 36 54 ( ( -LRB- cord-270528-3rsv3jlh 36 55 11 11 CD cord-270528-3rsv3jlh 36 56 ) ) -RRB- cord-270528-3rsv3jlh 36 57 . . . cord-270528-3rsv3jlh 37 1 Since since IN cord-270528-3rsv3jlh 37 2 both both DT cord-270528-3rsv3jlh 37 3 SARS SARS NNP cord-270528-3rsv3jlh 37 4 - - HYPH cord-270528-3rsv3jlh 37 5 CoV CoV NNP cord-270528-3rsv3jlh 37 6 and and CC cord-270528-3rsv3jlh 37 7 SARS SARS NNP cord-270528-3rsv3jlh 37 8 - - HYPH cord-270528-3rsv3jlh 37 9 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 37 10 have have VBP cord-270528-3rsv3jlh 37 11 the the DT cord-270528-3rsv3jlh 37 12 same same JJ cord-270528-3rsv3jlh 37 13 cell cell NN cord-270528-3rsv3jlh 37 14 entry entry NN cord-270528-3rsv3jlh 37 15 mechanism mechanism NN cord-270528-3rsv3jlh 37 16 , , , cord-270528-3rsv3jlh 37 17 the the DT cord-270528-3rsv3jlh 37 18 pathogenesis pathogenesis NN cord-270528-3rsv3jlh 37 19 of of IN cord-270528-3rsv3jlh 37 20 both both DT cord-270528-3rsv3jlh 37 21 viruses virus NNS cord-270528-3rsv3jlh 37 22 could could MD cord-270528-3rsv3jlh 37 23 be be VB cord-270528-3rsv3jlh 37 24 the the DT cord-270528-3rsv3jlh 37 25 same same JJ cord-270528-3rsv3jlh 37 26 , , , cord-270528-3rsv3jlh 37 27 or or CC cord-270528-3rsv3jlh 37 28 at at IN cord-270528-3rsv3jlh 37 29 least least JJS cord-270528-3rsv3jlh 37 30 very very RB cord-270528-3rsv3jlh 37 31 similar similar JJ cord-270528-3rsv3jlh 37 32 ( ( -LRB- cord-270528-3rsv3jlh 37 33 12 12 CD cord-270528-3rsv3jlh 37 34 ) ) -RRB- cord-270528-3rsv3jlh 37 35 . . . cord-270528-3rsv3jlh 38 1 ACE2 ACE2 NNP cord-270528-3rsv3jlh 38 2 is be VBZ cord-270528-3rsv3jlh 38 3 the the DT cord-270528-3rsv3jlh 38 4 common common JJ cord-270528-3rsv3jlh 38 5 factor factor NN cord-270528-3rsv3jlh 38 6 that that WDT cord-270528-3rsv3jlh 38 7 binds bind VBZ cord-270528-3rsv3jlh 38 8 to to IN cord-270528-3rsv3jlh 38 9 the the DT cord-270528-3rsv3jlh 38 10 superficial superficial JJ cord-270528-3rsv3jlh 38 11 S S NNP cord-270528-3rsv3jlh 38 12 glycoprotein glycoprotein NN cord-270528-3rsv3jlh 38 13 on on IN cord-270528-3rsv3jlh 38 14 the the DT cord-270528-3rsv3jlh 38 15 envelope envelope NN cord-270528-3rsv3jlh 38 16 of of IN cord-270528-3rsv3jlh 38 17 the the DT cord-270528-3rsv3jlh 38 18 virus virus NN cord-270528-3rsv3jlh 38 19 . . . cord-270528-3rsv3jlh 39 1 It -PRON- PRP cord-270528-3rsv3jlh 39 2 seems seem VBZ cord-270528-3rsv3jlh 39 3 that that IN cord-270528-3rsv3jlh 39 4 this this DT cord-270528-3rsv3jlh 39 5 binding binding NN cord-270528-3rsv3jlh 39 6 is be VBZ cord-270528-3rsv3jlh 39 7 sensed sense VBN cord-270528-3rsv3jlh 39 8 ( ( -LRB- cord-270528-3rsv3jlh 39 9 essentially essentially RB cord-270528-3rsv3jlh 39 10 ) ) -RRB- cord-270528-3rsv3jlh 39 11 by by IN cord-270528-3rsv3jlh 39 12 Toll toll NN cord-270528-3rsv3jlh 39 13 - - HYPH cord-270528-3rsv3jlh 39 14 like like IN cord-270528-3rsv3jlh 39 15 receptor-7 receptor-7 NNP cord-270528-3rsv3jlh 39 16 ( ( -LRB- cord-270528-3rsv3jlh 39 17 TLR-7 TLR-7 NNP cord-270528-3rsv3jlh 39 18 ) ) -RRB- cord-270528-3rsv3jlh 39 19 , , , cord-270528-3rsv3jlh 39 20 which which WDT cord-270528-3rsv3jlh 39 21 is be VBZ cord-270528-3rsv3jlh 39 22 present present JJ cord-270528-3rsv3jlh 39 23 in in IN cord-270528-3rsv3jlh 39 24 endosomes endosome NNS cord-270528-3rsv3jlh 39 25 , , , cord-270528-3rsv3jlh 39 26 and and CC cord-270528-3rsv3jlh 39 27 which which WDT cord-270528-3rsv3jlh 39 28 then then RB cord-270528-3rsv3jlh 39 29 leads lead VBZ cord-270528-3rsv3jlh 39 30 to to IN cord-270528-3rsv3jlh 39 31 the the DT cord-270528-3rsv3jlh 39 32 secretion secretion NN cord-270528-3rsv3jlh 39 33 of of IN cord-270528-3rsv3jlh 39 34 inflammatory inflammatory JJ cord-270528-3rsv3jlh 39 35 cytokines cytokine NNS cord-270528-3rsv3jlh 39 36 ( ( -LRB- cord-270528-3rsv3jlh 39 37 13 13 CD cord-270528-3rsv3jlh 39 38 , , , cord-270528-3rsv3jlh 39 39 14 14 CD cord-270528-3rsv3jlh 39 40 ) ) -RRB- cord-270528-3rsv3jlh 39 41 . . . cord-270528-3rsv3jlh 40 1 ACE2 ACE2 NNP cord-270528-3rsv3jlh 40 2 is be VBZ cord-270528-3rsv3jlh 40 3 highly highly RB cord-270528-3rsv3jlh 40 4 expressed express VBN cord-270528-3rsv3jlh 40 5 in in IN cord-270528-3rsv3jlh 40 6 some some DT cord-270528-3rsv3jlh 40 7 organs organ NNS cord-270528-3rsv3jlh 40 8 , , , cord-270528-3rsv3jlh 40 9 like like IN cord-270528-3rsv3jlh 40 10 lung lung NN cord-270528-3rsv3jlh 40 11 epithelial epithelial JJ cord-270528-3rsv3jlh 40 12 cells cell NNS cord-270528-3rsv3jlh 40 13 , , , cord-270528-3rsv3jlh 40 14 especially especially RB cord-270528-3rsv3jlh 40 15 type type NN cord-270528-3rsv3jlh 40 16 II II NNP cord-270528-3rsv3jlh 40 17 pneumocytes pneumocyte NNS cord-270528-3rsv3jlh 40 18 , , , cord-270528-3rsv3jlh 40 19 and and CC cord-270528-3rsv3jlh 40 20 in in IN cord-270528-3rsv3jlh 40 21 cells cell NNS cord-270528-3rsv3jlh 40 22 of of IN cord-270528-3rsv3jlh 40 23 the the DT cord-270528-3rsv3jlh 40 24 heart heart NN cord-270528-3rsv3jlh 40 25 , , , cord-270528-3rsv3jlh 40 26 kidneys kidney NNS cord-270528-3rsv3jlh 40 27 , , , cord-270528-3rsv3jlh 40 28 gastrointestinal gastrointestinal JJ cord-270528-3rsv3jlh 40 29 tract tract NN cord-270528-3rsv3jlh 40 30 , , , cord-270528-3rsv3jlh 40 31 liver liver NN cord-270528-3rsv3jlh 40 32 , , , cord-270528-3rsv3jlh 40 33 and and CC cord-270528-3rsv3jlh 40 34 bladder bladder NN cord-270528-3rsv3jlh 40 35 ( ( -LRB- cord-270528-3rsv3jlh 40 36 15 15 CD cord-270528-3rsv3jlh 40 37 , , , cord-270528-3rsv3jlh 40 38 16 16 CD cord-270528-3rsv3jlh 40 39 ) ) -RRB- cord-270528-3rsv3jlh 40 40 . . . cord-270528-3rsv3jlh 41 1 Therefore therefore RB cord-270528-3rsv3jlh 41 2 these these DT cord-270528-3rsv3jlh 41 3 organs organ NNS cord-270528-3rsv3jlh 41 4 constitute constitute VBP cord-270528-3rsv3jlh 41 5 the the DT cord-270528-3rsv3jlh 41 6 main main JJ cord-270528-3rsv3jlh 41 7 target target NN cord-270528-3rsv3jlh 41 8 for for IN cord-270528-3rsv3jlh 41 9 the the DT cord-270528-3rsv3jlh 41 10 virus virus NN cord-270528-3rsv3jlh 41 11 . . . cord-270528-3rsv3jlh 42 1 Following follow VBG cord-270528-3rsv3jlh 42 2 entry entry NN cord-270528-3rsv3jlh 42 3 of of IN cord-270528-3rsv3jlh 42 4 SARS SARS NNP cord-270528-3rsv3jlh 42 5 - - HYPH cord-270528-3rsv3jlh 42 6 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 42 7 into into IN cord-270528-3rsv3jlh 42 8 the the DT cord-270528-3rsv3jlh 42 9 cell cell NN cord-270528-3rsv3jlh 42 10 , , , cord-270528-3rsv3jlh 42 11 the the DT cord-270528-3rsv3jlh 42 12 viral viral JJ cord-270528-3rsv3jlh 42 13 RNA RNA NNP cord-270528-3rsv3jlh 42 14 genome genome NN cord-270528-3rsv3jlh 42 15 is be VBZ cord-270528-3rsv3jlh 42 16 transferred transfer VBN cord-270528-3rsv3jlh 42 17 from from IN cord-270528-3rsv3jlh 42 18 the the DT cord-270528-3rsv3jlh 42 19 envelope envelope NN cord-270528-3rsv3jlh 42 20 into into IN cord-270528-3rsv3jlh 42 21 the the DT cord-270528-3rsv3jlh 42 22 cytoplasm cytoplasm NN cord-270528-3rsv3jlh 42 23 and and CC cord-270528-3rsv3jlh 42 24 the the DT cord-270528-3rsv3jlh 42 25 translation translation NN cord-270528-3rsv3jlh 42 26 process process NN cord-270528-3rsv3jlh 42 27 begins begin VBZ cord-270528-3rsv3jlh 42 28 . . . cord-270528-3rsv3jlh 43 1 After after IN cord-270528-3rsv3jlh 43 2 replication replication NN cord-270528-3rsv3jlh 43 3 of of IN cord-270528-3rsv3jlh 43 4 the the DT cord-270528-3rsv3jlh 43 5 RNA RNA NNP cord-270528-3rsv3jlh 43 6 new new JJ cord-270528-3rsv3jlh 43 7 viral viral JJ cord-270528-3rsv3jlh 43 8 particles particle NNS cord-270528-3rsv3jlh 43 9 are be VBP cord-270528-3rsv3jlh 43 10 formed form VBN cord-270528-3rsv3jlh 43 11 , , , cord-270528-3rsv3jlh 43 12 by by IN cord-270528-3rsv3jlh 43 13 incorporating incorporate VBG cord-270528-3rsv3jlh 43 14 part part NN cord-270528-3rsv3jlh 43 15 of of IN cord-270528-3rsv3jlh 43 16 the the DT cord-270528-3rsv3jlh 43 17 host host NN cord-270528-3rsv3jlh 43 18 cell cell NN cord-270528-3rsv3jlh 43 19 membrane membrane NN cord-270528-3rsv3jlh 43 20 in in IN cord-270528-3rsv3jlh 43 21 the the DT cord-270528-3rsv3jlh 43 22 new new JJ cord-270528-3rsv3jlh 43 23 viral viral JJ cord-270528-3rsv3jlh 43 24 envelope envelope NN cord-270528-3rsv3jlh 43 25 . . . cord-270528-3rsv3jlh 44 1 Although although IN cord-270528-3rsv3jlh 44 2 , , , cord-270528-3rsv3jlh 44 3 SARS SARS NNP cord-270528-3rsv3jlh 44 4 - - HYPH cord-270528-3rsv3jlh 44 5 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 44 6 buds bud NNS cord-270528-3rsv3jlh 44 7 from from IN cord-270528-3rsv3jlh 44 8 the the DT cord-270528-3rsv3jlh 44 9 infected infected JJ cord-270528-3rsv3jlh 44 10 cell cell NN cord-270528-3rsv3jlh 44 11 , , , cord-270528-3rsv3jlh 44 12 it -PRON- PRP cord-270528-3rsv3jlh 44 13 does do VBZ cord-270528-3rsv3jlh 44 14 not not RB cord-270528-3rsv3jlh 44 15 lyse lyse VB cord-270528-3rsv3jlh 44 16 it -PRON- PRP cord-270528-3rsv3jlh 44 17 directly directly RB cord-270528-3rsv3jlh 44 18 ( ( -LRB- cord-270528-3rsv3jlh 44 19 17 17 CD cord-270528-3rsv3jlh 44 20 ) ) -RRB- cord-270528-3rsv3jlh 44 21 . . . cord-270528-3rsv3jlh 45 1 Infected infected JJ cord-270528-3rsv3jlh 45 2 lung lung NN cord-270528-3rsv3jlh 45 3 epithelial epithelial NN cord-270528-3rsv3jlh 45 4 cells cell NNS cord-270528-3rsv3jlh 45 5 produce produce VBP cord-270528-3rsv3jlh 45 6 interleukin interleukin NN cord-270528-3rsv3jlh 45 7 ( ( -LRB- cord-270528-3rsv3jlh 45 8 IL)-8 IL)-8 NNP cord-270528-3rsv3jlh 45 9 which which WDT cord-270528-3rsv3jlh 45 10 acts act VBZ cord-270528-3rsv3jlh 45 11 as as IN cord-270528-3rsv3jlh 45 12 a a DT cord-270528-3rsv3jlh 45 13 chemoattractant chemoattractant NN cord-270528-3rsv3jlh 45 14 for for IN cord-270528-3rsv3jlh 45 15 neutrophils neutrophil NNS cord-270528-3rsv3jlh 45 16 and and CC cord-270528-3rsv3jlh 45 17 T t NN cord-270528-3rsv3jlh 45 18 lymphocytes lymphocyte NNS cord-270528-3rsv3jlh 45 19 ( ( -LRB- cord-270528-3rsv3jlh 45 20 18 18 CD cord-270528-3rsv3jlh 45 21 ) ) -RRB- cord-270528-3rsv3jlh 45 22 . . . cord-270528-3rsv3jlh 46 1 The the DT cord-270528-3rsv3jlh 46 2 innate innate JJ cord-270528-3rsv3jlh 46 3 immune immune JJ cord-270528-3rsv3jlh 46 4 response response NN cord-270528-3rsv3jlh 46 5 is be VBZ cord-270528-3rsv3jlh 46 6 J J NNP cord-270528-3rsv3jlh 46 7 o o NNP cord-270528-3rsv3jlh 46 8 u u NN cord-270528-3rsv3jlh 46 9 r r NN cord-270528-3rsv3jlh 46 10 n n NN cord-270528-3rsv3jlh 46 11 a a DT cord-270528-3rsv3jlh 46 12 l l NN cord-270528-3rsv3jlh 46 13 P p NN cord-270528-3rsv3jlh 46 14 r r NN cord-270528-3rsv3jlh 46 15 e e NN cord-270528-3rsv3jlh 46 16 -p -p NN cord-270528-3rsv3jlh 46 17 r r NN cord-270528-3rsv3jlh 47 1 o o UH cord-270528-3rsv3jlh 47 2 o o NN cord-270528-3rsv3jlh 47 3 f f NN cord-270528-3rsv3jlh 47 4 5 5 CD cord-270528-3rsv3jlh 47 5 initially initially RB cord-270528-3rsv3jlh 47 6 triggered trigger VBN cord-270528-3rsv3jlh 47 7 by by IN cord-270528-3rsv3jlh 47 8 lung lung NN cord-270528-3rsv3jlh 47 9 epithelial epithelial JJ cord-270528-3rsv3jlh 47 10 cells cell NNS cord-270528-3rsv3jlh 47 11 , , , cord-270528-3rsv3jlh 47 12 alveolar alveolar JJ cord-270528-3rsv3jlh 47 13 macrophages macrophage NNS cord-270528-3rsv3jlh 47 14 and and CC cord-270528-3rsv3jlh 47 15 neutrophils neutrophil NNS cord-270528-3rsv3jlh 47 16 . . . cord-270528-3rsv3jlh 48 1 In in IN cord-270528-3rsv3jlh 48 2 the the DT cord-270528-3rsv3jlh 48 3 next next JJ cord-270528-3rsv3jlh 48 4 stage stage NN cord-270528-3rsv3jlh 48 5 , , , cord-270528-3rsv3jlh 48 6 adaptive adaptive JJ cord-270528-3rsv3jlh 48 7 immune immune JJ cord-270528-3rsv3jlh 48 8 responses response NNS cord-270528-3rsv3jlh 48 9 are be VBP cord-270528-3rsv3jlh 48 10 triggered trigger VBN cord-270528-3rsv3jlh 48 11 involving involve VBG cord-270528-3rsv3jlh 48 12 T t NN cord-270528-3rsv3jlh 48 13 and and CC cord-270528-3rsv3jlh 48 14 B b NN cord-270528-3rsv3jlh 48 15 lymphocytes lymphocyte NNS cord-270528-3rsv3jlh 48 16 to to TO cord-270528-3rsv3jlh 48 17 complete complete VB cord-270528-3rsv3jlh 48 18 the the DT cord-270528-3rsv3jlh 48 19 complete complete JJ cord-270528-3rsv3jlh 48 20 immune immune JJ cord-270528-3rsv3jlh 48 21 response response NN cord-270528-3rsv3jlh 48 22 ( ( -LRB- cord-270528-3rsv3jlh 48 23 19 19 CD cord-270528-3rsv3jlh 48 24 ) ) -RRB- cord-270528-3rsv3jlh 48 25 . . . cord-270528-3rsv3jlh 49 1 Virus virus NN cord-270528-3rsv3jlh 49 2 particles particle NNS cord-270528-3rsv3jlh 49 3 containing contain VBG cord-270528-3rsv3jlh 49 4 single single RB cord-270528-3rsv3jlh 49 5 - - HYPH cord-270528-3rsv3jlh 49 6 stranded stranded JJ cord-270528-3rsv3jlh 49 7 ssRNA ssrna NN cord-270528-3rsv3jlh 49 8 , , , cord-270528-3rsv3jlh 49 9 act act VB cord-270528-3rsv3jlh 49 10 as as IN cord-270528-3rsv3jlh 49 11 pathogen pathogen NN cord-270528-3rsv3jlh 49 12 - - HYPH cord-270528-3rsv3jlh 49 13 associated associate VBN cord-270528-3rsv3jlh 49 14 molecular molecular JJ cord-270528-3rsv3jlh 49 15 patterns pattern NNS cord-270528-3rsv3jlh 49 16 ( ( -LRB- cord-270528-3rsv3jlh 49 17 PAMPs PAMPs NNP cord-270528-3rsv3jlh 49 18 ) ) -RRB- cord-270528-3rsv3jlh 49 19 , , , cord-270528-3rsv3jlh 49 20 and and CC cord-270528-3rsv3jlh 49 21 provoke provoke VB cord-270528-3rsv3jlh 49 22 a a DT cord-270528-3rsv3jlh 49 23 strong strong JJ cord-270528-3rsv3jlh 49 24 innate innate JJ cord-270528-3rsv3jlh 49 25 immune immune JJ cord-270528-3rsv3jlh 49 26 response response NN cord-270528-3rsv3jlh 49 27 after after IN cord-270528-3rsv3jlh 49 28 recognition recognition NN cord-270528-3rsv3jlh 49 29 by by IN cord-270528-3rsv3jlh 49 30 Toll Toll NNP cord-270528-3rsv3jlh 49 31 - - HYPH cord-270528-3rsv3jlh 49 32 like like JJ cord-270528-3rsv3jlh 49 33 receptor receptor NN cord-270528-3rsv3jlh 49 34 7 7 CD cord-270528-3rsv3jlh 49 35 ( ( -LRB- cord-270528-3rsv3jlh 49 36 TLR7 TLR7 NNP cord-270528-3rsv3jlh 49 37 ) ) -RRB- cord-270528-3rsv3jlh 49 38 , , , cord-270528-3rsv3jlh 49 39 which which WDT cord-270528-3rsv3jlh 49 40 is be VBZ cord-270528-3rsv3jlh 49 41 expressed express VBN cord-270528-3rsv3jlh 49 42 on on IN cord-270528-3rsv3jlh 49 43 monocytemacrophages monocytemacrophage NNS cord-270528-3rsv3jlh 49 44 and and CC cord-270528-3rsv3jlh 49 45 dendritic dendritic JJ cord-270528-3rsv3jlh 49 46 cells cell NNS cord-270528-3rsv3jlh 49 47 ( ( -LRB- cord-270528-3rsv3jlh 49 48 DC DC NNP cord-270528-3rsv3jlh 49 49 ) ) -RRB- cord-270528-3rsv3jlh 49 50 . . . cord-270528-3rsv3jlh 50 1 TLR7 TLR7 NNP cord-270528-3rsv3jlh 50 2 can can MD cord-270528-3rsv3jlh 50 3 activate activate VB cord-270528-3rsv3jlh 50 4 several several JJ cord-270528-3rsv3jlh 50 5 signaling signal VBG cord-270528-3rsv3jlh 50 6 pathways pathway NNS cord-270528-3rsv3jlh 50 7 and and CC cord-270528-3rsv3jlh 50 8 transcription transcription NN cord-270528-3rsv3jlh 50 9 factors factor NNS cord-270528-3rsv3jlh 50 10 , , , cord-270528-3rsv3jlh 50 11 such such JJ cord-270528-3rsv3jlh 50 12 as as IN cord-270528-3rsv3jlh 50 13 Janus Janus NNP cord-270528-3rsv3jlh 50 14 kinase kinase NN cord-270528-3rsv3jlh 50 15 transducers transducer NNS cord-270528-3rsv3jlh 50 16 ( ( -LRB- cord-270528-3rsv3jlh 50 17 JAK JAK NNP cord-270528-3rsv3jlh 50 18 / / SYM cord-270528-3rsv3jlh 50 19 STAT STAT NNP cord-270528-3rsv3jlh 50 20 ) ) -RRB- cord-270528-3rsv3jlh 50 21 , , , cord-270528-3rsv3jlh 50 22 nuclear nuclear JJ cord-270528-3rsv3jlh 50 23 factor factor NN cord-270528-3rsv3jlh 51 1 κB κB NNP cord-270528-3rsv3jlh 52 1 ( ( -LRB- cord-270528-3rsv3jlh 52 2 NF nf NN cord-270528-3rsv3jlh 52 3 - - HYPH cord-270528-3rsv3jlh 52 4 κB κB NNP cord-270528-3rsv3jlh 52 5 ) ) -RRB- cord-270528-3rsv3jlh 52 6 , , , cord-270528-3rsv3jlh 52 7 activator activator NN cord-270528-3rsv3jlh 52 8 protein protein NN cord-270528-3rsv3jlh 52 9 1 1 CD cord-270528-3rsv3jlh 52 10 ( ( -LRB- cord-270528-3rsv3jlh 52 11 AP-1 AP-1 NNP cord-270528-3rsv3jlh 52 12 ) ) -RRB- cord-270528-3rsv3jlh 52 13 , , , cord-270528-3rsv3jlh 52 14 interferon interferon NN cord-270528-3rsv3jlh 52 15 response response NN cord-270528-3rsv3jlh 52 16 factor factor NN cord-270528-3rsv3jlh 52 17 3 3 CD cord-270528-3rsv3jlh 52 18 ( ( -LRB- cord-270528-3rsv3jlh 52 19 IRF3 IRF3 NNP cord-270528-3rsv3jlh 52 20 ) ) -RRB- cord-270528-3rsv3jlh 52 21 , , , cord-270528-3rsv3jlh 52 22 and and CC cord-270528-3rsv3jlh 52 23 IRF7 IRF7 NNP cord-270528-3rsv3jlh 52 24 . . . cord-270528-3rsv3jlh 53 1 This this DT cord-270528-3rsv3jlh 53 2 signaling signal VBG cord-270528-3rsv3jlh 53 3 cascade cascade NN cord-270528-3rsv3jlh 53 4 leads lead NNS cord-270528-3rsv3jlh 53 5 to to IN cord-270528-3rsv3jlh 53 6 increased increase VBN cord-270528-3rsv3jlh 53 7 secretion secretion NN cord-270528-3rsv3jlh 53 8 of of IN cord-270528-3rsv3jlh 53 9 pro pro JJ cord-270528-3rsv3jlh 53 10 - - JJ cord-270528-3rsv3jlh 53 11 inflammatory inflammatory JJ cord-270528-3rsv3jlh 53 12 cytokines cytokine NNS cord-270528-3rsv3jlh 53 13 , , , cord-270528-3rsv3jlh 53 14 like like IN cord-270528-3rsv3jlh 53 15 IL-1 IL-1 NNP cord-270528-3rsv3jlh 53 16 , , , cord-270528-3rsv3jlh 53 17 IL-6 IL-6 NNP cord-270528-3rsv3jlh 53 18 , , , cord-270528-3rsv3jlh 53 19 monocyte monocyte NNP cord-270528-3rsv3jlh 53 20 chemo chemo NN cord-270528-3rsv3jlh 53 21 attractant attractant NN cord-270528-3rsv3jlh 53 22 protein-1 protein-1 NNP cord-270528-3rsv3jlh 53 23 ( ( -LRB- cord-270528-3rsv3jlh 53 24 MCP-1 MCP-1 NNP cord-270528-3rsv3jlh 53 25 ) ) -RRB- cord-270528-3rsv3jlh 53 26 , , , cord-270528-3rsv3jlh 53 27 MIP-1A MIP-1A NNP cord-270528-3rsv3jlh 53 28 , , , cord-270528-3rsv3jlh 53 29 tumor tumor NN cord-270528-3rsv3jlh 53 30 necrosis necrosis NN cord-270528-3rsv3jlh 53 31 factor factor NN cord-270528-3rsv3jlh 53 32 α α NNP cord-270528-3rsv3jlh 53 33 ( ( -LRB- cord-270528-3rsv3jlh 53 34 TNF TNF NNP cord-270528-3rsv3jlh 53 35 - - HYPH cord-270528-3rsv3jlh 53 36 α α NNP cord-270528-3rsv3jlh 53 37 ) ) -RRB- cord-270528-3rsv3jlh 53 38 and and CC cord-270528-3rsv3jlh 53 39 ultimately ultimately RB cord-270528-3rsv3jlh 53 40 interferon interferon NN cord-270528-3rsv3jlh 53 41 1 1 CD cord-270528-3rsv3jlh 53 42 ( ( -LRB- cord-270528-3rsv3jlh 53 43 IFN1 IFN1 NNP cord-270528-3rsv3jlh 53 44 ) ) -RRB- cord-270528-3rsv3jlh 53 45 ( ( -LRB- cord-270528-3rsv3jlh 53 46 20 20 CD cord-270528-3rsv3jlh 53 47 ) ) -RRB- cord-270528-3rsv3jlh 53 48 . . . cord-270528-3rsv3jlh 54 1 Furthermore furthermore RB cord-270528-3rsv3jlh 54 2 , , , cord-270528-3rsv3jlh 54 3 neutrophils neutrophil NNS cord-270528-3rsv3jlh 54 4 are be VBP cord-270528-3rsv3jlh 54 5 rapidly rapidly RB cord-270528-3rsv3jlh 54 6 recruited recruit VBN cord-270528-3rsv3jlh 54 7 to to IN cord-270528-3rsv3jlh 54 8 sites site NNS cord-270528-3rsv3jlh 54 9 of of IN cord-270528-3rsv3jlh 54 10 infection infection NN cord-270528-3rsv3jlh 54 11 , , , cord-270528-3rsv3jlh 54 12 where where WRB cord-270528-3rsv3jlh 54 13 they -PRON- PRP cord-270528-3rsv3jlh 54 14 kill kill VBP cord-270528-3rsv3jlh 54 15 viruses virus NNS cord-270528-3rsv3jlh 54 16 by by IN cord-270528-3rsv3jlh 54 17 an an DT cord-270528-3rsv3jlh 54 18 oxidative oxidative JJ cord-270528-3rsv3jlh 54 19 burst burst NN cord-270528-3rsv3jlh 54 20 , , , cord-270528-3rsv3jlh 54 21 defensin defensin NN cord-270528-3rsv3jlh 54 22 secretion secretion NN cord-270528-3rsv3jlh 54 23 , , , cord-270528-3rsv3jlh 54 24 and and CC cord-270528-3rsv3jlh 54 25 neutrophil neutrophil NN cord-270528-3rsv3jlh 54 26 extracellular extracellular JJ cord-270528-3rsv3jlh 54 27 traps trap NNS cord-270528-3rsv3jlh 54 28 ( ( -LRB- cord-270528-3rsv3jlh 54 29 NETs nets NN cord-270528-3rsv3jlh 54 30 ) ) -RRB- cord-270528-3rsv3jlh 54 31 ( ( -LRB- cord-270528-3rsv3jlh 54 32 21 21 CD cord-270528-3rsv3jlh 54 33 ) ) -RRB- cord-270528-3rsv3jlh 54 34 . . . cord-270528-3rsv3jlh 55 1 Along along IN cord-270528-3rsv3jlh 55 2 with with IN cord-270528-3rsv3jlh 55 3 these these DT cord-270528-3rsv3jlh 55 4 events event NNS cord-270528-3rsv3jlh 55 5 , , , cord-270528-3rsv3jlh 55 6 antigen antigen NN cord-270528-3rsv3jlh 55 7 presentation presentation NN cord-270528-3rsv3jlh 55 8 subsequently subsequently RB cord-270528-3rsv3jlh 55 9 stimulates stimulate VBZ cord-270528-3rsv3jlh 55 10 the the DT cord-270528-3rsv3jlh 55 11 body body NN cord-270528-3rsv3jlh 55 12 's 's POS cord-270528-3rsv3jlh 55 13 specific specific JJ cord-270528-3rsv3jlh 55 14 adaptive adaptive JJ cord-270528-3rsv3jlh 55 15 immunity immunity NN cord-270528-3rsv3jlh 55 16 ( ( -LRB- cord-270528-3rsv3jlh 55 17 both both DT cord-270528-3rsv3jlh 55 18 humoral humoral JJ cord-270528-3rsv3jlh 55 19 and and CC cord-270528-3rsv3jlh 55 20 cellular cellular JJ cord-270528-3rsv3jlh 55 21 immunity immunity NN cord-270528-3rsv3jlh 55 22 ) ) -RRB- cord-270528-3rsv3jlh 55 23 which which WDT cord-270528-3rsv3jlh 55 24 culminates culminate VBZ cord-270528-3rsv3jlh 55 25 in in IN cord-270528-3rsv3jlh 55 26 approximately approximately RB cord-270528-3rsv3jlh 55 27 7 7 CD cord-270528-3rsv3jlh 55 28 - - SYM cord-270528-3rsv3jlh 55 29 14 14 CD cord-270528-3rsv3jlh 55 30 days day NNS cord-270528-3rsv3jlh 55 31 after after IN cord-270528-3rsv3jlh 55 32 infection infection NN cord-270528-3rsv3jlh 55 33 . . . cord-270528-3rsv3jlh 56 1 Following follow VBG cord-270528-3rsv3jlh 56 2 the the DT cord-270528-3rsv3jlh 56 3 representation representation NN cord-270528-3rsv3jlh 56 4 of of IN cord-270528-3rsv3jlh 56 5 antigens antigen NNS cord-270528-3rsv3jlh 56 6 by by IN cord-270528-3rsv3jlh 56 7 APCs apc NNS cord-270528-3rsv3jlh 56 8 to to IN cord-270528-3rsv3jlh 56 9 the the DT cord-270528-3rsv3jlh 56 10 CD4 CD4 NNP cord-270528-3rsv3jlh 56 11 + + CC cord-270528-3rsv3jlh 56 12 and and CC cord-270528-3rsv3jlh 56 13 CD8 CD8 NNP cord-270528-3rsv3jlh 56 14 + + CC cord-270528-3rsv3jlh 56 15 T T NNP cord-270528-3rsv3jlh 56 16 - - HYPH cord-270528-3rsv3jlh 56 17 cells cell NNS cord-270528-3rsv3jlh 56 18 , , , cord-270528-3rsv3jlh 56 19 pro pro JJ cord-270528-3rsv3jlh 56 20 - - JJ cord-270528-3rsv3jlh 56 21 inflammatory inflammatory JJ cord-270528-3rsv3jlh 56 22 cytokines cytokine NNS cord-270528-3rsv3jlh 56 23 are be VBP cord-270528-3rsv3jlh 56 24 produced produce VBN cord-270528-3rsv3jlh 56 25 via via IN cord-270528-3rsv3jlh 56 26 the the DT cord-270528-3rsv3jlh 56 27 NF nf NN cord-270528-3rsv3jlh 56 28 - - HYPH cord-270528-3rsv3jlh 56 29 κB κB NNP cord-270528-3rsv3jlh 56 30 signaling signal VBG cord-270528-3rsv3jlh 56 31 pathway pathway NN cord-270528-3rsv3jlh 56 32 . . . cord-270528-3rsv3jlh 57 1 Activated activate VBN cord-270528-3rsv3jlh 57 2 B B NNP cord-270528-3rsv3jlh 57 3 cells cell NNS cord-270528-3rsv3jlh 57 4 secrete secrete VBP cord-270528-3rsv3jlh 57 5 virus virus NN cord-270528-3rsv3jlh 57 6 - - HYPH cord-270528-3rsv3jlh 57 7 specific specific JJ cord-270528-3rsv3jlh 57 8 antibodies antibody NNS cord-270528-3rsv3jlh 57 9 , , , cord-270528-3rsv3jlh 57 10 while while IN cord-270528-3rsv3jlh 57 11 antigen antigen NN cord-270528-3rsv3jlh 57 12 - - HYPH cord-270528-3rsv3jlh 57 13 specific specific JJ cord-270528-3rsv3jlh 57 14 T t NN cord-270528-3rsv3jlh 57 15 cytotoxic cytotoxic JJ cord-270528-3rsv3jlh 57 16 cells cell NNS cord-270528-3rsv3jlh 57 17 kill kill VBP cord-270528-3rsv3jlh 57 18 virus virus NN cord-270528-3rsv3jlh 57 19 - - HYPH cord-270528-3rsv3jlh 57 20 infected infect VBN cord-270528-3rsv3jlh 57 21 cells cell NNS cord-270528-3rsv3jlh 57 22 ( ( -LRB- cord-270528-3rsv3jlh 57 23 17 17 CD cord-270528-3rsv3jlh 57 24 , , , cord-270528-3rsv3jlh 57 25 22 22 CD cord-270528-3rsv3jlh 57 26 ) ) -RRB- cord-270528-3rsv3jlh 57 27 . . . cord-270528-3rsv3jlh 58 1 Additionally additionally RB cord-270528-3rsv3jlh 58 2 , , , cord-270528-3rsv3jlh 58 3 Th17 th17 NN cord-270528-3rsv3jlh 58 4 cells cell NNS cord-270528-3rsv3jlh 58 5 , , , cord-270528-3rsv3jlh 58 6 neutrophils neutrophil NNS cord-270528-3rsv3jlh 58 7 , , , cord-270528-3rsv3jlh 58 8 and and CC cord-270528-3rsv3jlh 58 9 granulocytes granulocyte NNS cord-270528-3rsv3jlh 58 10 secrete secrete VBP cord-270528-3rsv3jlh 58 11 IL-17 IL-17 NNP cord-270528-3rsv3jlh 58 12 , , , cord-270528-3rsv3jlh 58 13 which which WDT cord-270528-3rsv3jlh 58 14 in in IN cord-270528-3rsv3jlh 58 15 turn turn NN cord-270528-3rsv3jlh 58 16 stimulates stimulate VBZ cord-270528-3rsv3jlh 58 17 production production NN cord-270528-3rsv3jlh 58 18 of of IN cord-270528-3rsv3jlh 58 19 IL-1 IL-1 NNP cord-270528-3rsv3jlh 58 20 , , , cord-270528-3rsv3jlh 58 21 IL-6 IL-6 NNP cord-270528-3rsv3jlh 58 22 , , , cord-270528-3rsv3jlh 58 23 IL-8 IL-8 NNP cord-270528-3rsv3jlh 58 24 , , , cord-270528-3rsv3jlh 58 25 MCP-1 MCP-1 NNP cord-270528-3rsv3jlh 58 26 , , , cord-270528-3rsv3jlh 58 27 Gro Gro NNP cord-270528-3rsv3jlh 58 28 - - HYPH cord-270528-3rsv3jlh 58 29 a a NNP cord-270528-3rsv3jlh 58 30 , , , cord-270528-3rsv3jlh 58 31 G G NNP cord-270528-3rsv3jlh 58 32 - - HYPH cord-270528-3rsv3jlh 58 33 CSF CSF NNP cord-270528-3rsv3jlh 58 34 , , , cord-270528-3rsv3jlh 58 35 GM GM NNP cord-270528-3rsv3jlh 58 36 - - HYPH cord-270528-3rsv3jlh 58 37 CSF CSF NNP cord-270528-3rsv3jlh 58 38 , , , cord-270528-3rsv3jlh 58 39 TNF TNF NNP cord-270528-3rsv3jlh 58 40 - - HYPH cord-270528-3rsv3jlh 58 41 α α NNP cord-270528-3rsv3jlh 58 42 , , , cord-270528-3rsv3jlh 58 43 and and CC cord-270528-3rsv3jlh 58 44 PGE2 PGE2 NNP cord-270528-3rsv3jlh 58 45 . . . cord-270528-3rsv3jlh 59 1 All all PDT cord-270528-3rsv3jlh 59 2 these these DT cord-270528-3rsv3jlh 59 3 mediators mediator NNS cord-270528-3rsv3jlh 59 4 can can MD cord-270528-3rsv3jlh 59 5 increase increase VB cord-270528-3rsv3jlh 59 6 the the DT cord-270528-3rsv3jlh 59 7 recruitment recruitment NN cord-270528-3rsv3jlh 59 8 of of IN cord-270528-3rsv3jlh 59 9 neutrophils neutrophil NNS cord-270528-3rsv3jlh 59 10 , , , cord-270528-3rsv3jlh 59 11 monocytes monocyte NNS cord-270528-3rsv3jlh 59 12 , , , cord-270528-3rsv3jlh 59 13 and and CC cord-270528-3rsv3jlh 59 14 other other JJ cord-270528-3rsv3jlh 59 15 immune immune JJ cord-270528-3rsv3jlh 59 16 cells cell NNS cord-270528-3rsv3jlh 59 17 . . . cord-270528-3rsv3jlh 60 1 Besides besides RB cord-270528-3rsv3jlh 60 2 , , , cord-270528-3rsv3jlh 60 3 it -PRON- PRP cord-270528-3rsv3jlh 60 4 has have VBZ cord-270528-3rsv3jlh 60 5 been be VBN cord-270528-3rsv3jlh 60 6 reported report VBN cord-270528-3rsv3jlh 60 7 that that IN cord-270528-3rsv3jlh 60 8 IL-17 IL-17 NNP cord-270528-3rsv3jlh 60 9 expression expression NN cord-270528-3rsv3jlh 60 10 is be VBZ cord-270528-3rsv3jlh 60 11 correlated correlate VBN cord-270528-3rsv3jlh 60 12 with with IN cord-270528-3rsv3jlh 60 13 several several JJ cord-270528-3rsv3jlh 60 14 inflammatory inflammatory JJ cord-270528-3rsv3jlh 60 15 J J NNP cord-270528-3rsv3jlh 60 16 o o NN cord-270528-3rsv3jlh 60 17 u u NN cord-270528-3rsv3jlh 60 18 r r NN cord-270528-3rsv3jlh 60 19 n n NN cord-270528-3rsv3jlh 60 20 a a DT cord-270528-3rsv3jlh 60 21 l l NN cord-270528-3rsv3jlh 60 22 P p NN cord-270528-3rsv3jlh 60 23 r r NN cord-270528-3rsv3jlh 60 24 e e NN cord-270528-3rsv3jlh 60 25 -p -p NN cord-270528-3rsv3jlh 60 26 r r NN cord-270528-3rsv3jlh 60 27 o o NN cord-270528-3rsv3jlh 60 28 o o NN cord-270528-3rsv3jlh 60 29 f f NN cord-270528-3rsv3jlh 60 30 6 6 CD cord-270528-3rsv3jlh 60 31 respiratory respiratory JJ cord-270528-3rsv3jlh 60 32 diseases disease NNS cord-270528-3rsv3jlh 60 33 ( ( -LRB- cord-270528-3rsv3jlh 60 34 23 23 CD cord-270528-3rsv3jlh 60 35 ) ) -RRB- cord-270528-3rsv3jlh 60 36 . . . cord-270528-3rsv3jlh 61 1 All all PDT cord-270528-3rsv3jlh 61 2 these these DT cord-270528-3rsv3jlh 61 3 immune immune VBP cord-270528-3rsv3jlh 61 4 signaling signal VBG cord-270528-3rsv3jlh 61 5 pathways pathway NNS cord-270528-3rsv3jlh 61 6 are be VBP cord-270528-3rsv3jlh 61 7 designed design VBN cord-270528-3rsv3jlh 61 8 to to TO cord-270528-3rsv3jlh 61 9 create create VB cord-270528-3rsv3jlh 61 10 an an DT cord-270528-3rsv3jlh 61 11 inflammatory inflammatory JJ cord-270528-3rsv3jlh 61 12 environment environment NN cord-270528-3rsv3jlh 61 13 with with IN cord-270528-3rsv3jlh 61 14 the the DT cord-270528-3rsv3jlh 61 15 goal goal NN cord-270528-3rsv3jlh 61 16 of of IN cord-270528-3rsv3jlh 61 17 eradicating eradicate VBG cord-270528-3rsv3jlh 61 18 SARS SARS NNP cord-270528-3rsv3jlh 61 19 - - HYPH cord-270528-3rsv3jlh 61 20 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 61 21 . . . cord-270528-3rsv3jlh 62 1 The the DT cord-270528-3rsv3jlh 62 2 pathology pathology NN cord-270528-3rsv3jlh 62 3 of of IN cord-270528-3rsv3jlh 62 4 SARS SARS NNP cord-270528-3rsv3jlh 62 5 - - HYPH cord-270528-3rsv3jlh 62 6 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 62 7 is be VBZ cord-270528-3rsv3jlh 62 8 not not RB cord-270528-3rsv3jlh 62 9 yet yet RB cord-270528-3rsv3jlh 62 10 completely completely RB cord-270528-3rsv3jlh 62 11 understood understand VBN cord-270528-3rsv3jlh 62 12 ; ; : cord-270528-3rsv3jlh 62 13 most most JJS cord-270528-3rsv3jlh 62 14 of of IN cord-270528-3rsv3jlh 62 15 our -PRON- PRP$ cord-270528-3rsv3jlh 62 16 knowledge knowledge NN cord-270528-3rsv3jlh 62 17 has have VBZ cord-270528-3rsv3jlh 62 18 been be VBN cord-270528-3rsv3jlh 62 19 based base VBN cord-270528-3rsv3jlh 62 20 on on IN cord-270528-3rsv3jlh 62 21 research research NN cord-270528-3rsv3jlh 62 22 into into IN cord-270528-3rsv3jlh 62 23 SARS SARS NNP cord-270528-3rsv3jlh 62 24 - - HYPH cord-270528-3rsv3jlh 62 25 CoV CoV NNP cord-270528-3rsv3jlh 62 26 and and CC cord-270528-3rsv3jlh 62 27 MERS MERS NNP cord-270528-3rsv3jlh 62 28 , , , cord-270528-3rsv3jlh 62 29 which which WDT cord-270528-3rsv3jlh 62 30 previously previously RB cord-270528-3rsv3jlh 62 31 caused cause VBD cord-270528-3rsv3jlh 62 32 epidemics epidemic NNS cord-270528-3rsv3jlh 62 33 of of IN cord-270528-3rsv3jlh 62 34 acute acute JJ cord-270528-3rsv3jlh 62 35 respiratory respiratory JJ cord-270528-3rsv3jlh 62 36 syndromes syndrome NNS cord-270528-3rsv3jlh 62 37 . . . cord-270528-3rsv3jlh 63 1 In in IN cord-270528-3rsv3jlh 63 2 this this DT cord-270528-3rsv3jlh 63 3 short short JJ cord-270528-3rsv3jlh 63 4 duration duration NN cord-270528-3rsv3jlh 63 5 of of IN cord-270528-3rsv3jlh 63 6 the the DT cord-270528-3rsv3jlh 63 7 present present JJ cord-270528-3rsv3jlh 63 8 pandemic pandemic NN cord-270528-3rsv3jlh 63 9 , , , cord-270528-3rsv3jlh 63 10 studies study NNS cord-270528-3rsv3jlh 63 11 have have VBP cord-270528-3rsv3jlh 63 12 shown show VBN cord-270528-3rsv3jlh 63 13 that that IN cord-270528-3rsv3jlh 63 14 SARS SARS NNP cord-270528-3rsv3jlh 63 15 - - HYPH cord-270528-3rsv3jlh 63 16 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 63 17 has have VBZ cord-270528-3rsv3jlh 63 18 several several JJ cord-270528-3rsv3jlh 63 19 defense defense NN cord-270528-3rsv3jlh 63 20 mechanisms mechanism NNS cord-270528-3rsv3jlh 63 21 , , , cord-270528-3rsv3jlh 63 22 which which WDT cord-270528-3rsv3jlh 63 23 makes make VBZ cord-270528-3rsv3jlh 63 24 its -PRON- PRP$ cord-270528-3rsv3jlh 63 25 eradication eradication NN cord-270528-3rsv3jlh 63 26 more more RBR cord-270528-3rsv3jlh 63 27 difficult difficult JJ cord-270528-3rsv3jlh 63 28 . . . cord-270528-3rsv3jlh 64 1 The the DT cord-270528-3rsv3jlh 64 2 ( ( -LRB- cord-270528-3rsv3jlh 64 3 7 7 CD cord-270528-3rsv3jlh 64 4 , , , cord-270528-3rsv3jlh 64 5 20 20 CD cord-270528-3rsv3jlh 64 6 , , , cord-270528-3rsv3jlh 64 7 24 24 CD cord-270528-3rsv3jlh 64 8 , , , cord-270528-3rsv3jlh 64 9 25 25 CD cord-270528-3rsv3jlh 64 10 ) ) -RRB- cord-270528-3rsv3jlh 64 11 . . . cord-270528-3rsv3jlh 65 1 Another another DT cord-270528-3rsv3jlh 65 2 important important JJ cord-270528-3rsv3jlh 65 3 observation observation NN cord-270528-3rsv3jlh 65 4 is be VBZ cord-270528-3rsv3jlh 65 5 the the DT cord-270528-3rsv3jlh 65 6 strong strong JJ cord-270528-3rsv3jlh 65 7 correlation correlation NN cord-270528-3rsv3jlh 65 8 between between IN cord-270528-3rsv3jlh 65 9 inflammatory inflammatory JJ cord-270528-3rsv3jlh 65 10 markers marker NNS cord-270528-3rsv3jlh 65 11 , , , cord-270528-3rsv3jlh 65 12 including include VBG cord-270528-3rsv3jlh 65 13 ESR ESR NNP cord-270528-3rsv3jlh 65 14 , , , cord-270528-3rsv3jlh 65 15 CRP CRP NNP cord-270528-3rsv3jlh 65 16 and and CC cord-270528-3rsv3jlh 65 17 IL-6 IL-6 NNP cord-270528-3rsv3jlh 65 18 , , , cord-270528-3rsv3jlh 65 19 and and CC cord-270528-3rsv3jlh 65 20 the the DT cord-270528-3rsv3jlh 65 21 relevant relevant JJ cord-270528-3rsv3jlh 65 22 subset subset NN cord-270528-3rsv3jlh 65 23 of of IN cord-270528-3rsv3jlh 65 24 lymphocytes lymphocyte NNS cord-270528-3rsv3jlh 65 25 ( ( -LRB- cord-270528-3rsv3jlh 65 26 26 26 CD cord-270528-3rsv3jlh 65 27 ) ) -RRB- cord-270528-3rsv3jlh 65 28 . . . cord-270528-3rsv3jlh 66 1 Overall overall RB cord-270528-3rsv3jlh 66 2 , , , cord-270528-3rsv3jlh 66 3 general general JJ cord-270528-3rsv3jlh 66 4 lymphopenia lymphopenia NNP cord-270528-3rsv3jlh 66 5 is be VBZ cord-270528-3rsv3jlh 66 6 seen see VBN cord-270528-3rsv3jlh 66 7 in in IN cord-270528-3rsv3jlh 66 8 COVID-19 covid-19 JJ cord-270528-3rsv3jlh 66 9 patients patient NNS cord-270528-3rsv3jlh 66 10 , , , cord-270528-3rsv3jlh 66 11 especially especially RB cord-270528-3rsv3jlh 66 12 in in IN cord-270528-3rsv3jlh 66 13 severe severe JJ cord-270528-3rsv3jlh 66 14 cases case NNS cord-270528-3rsv3jlh 66 15 ( ( -LRB- cord-270528-3rsv3jlh 66 16 27 27 CD cord-270528-3rsv3jlh 66 17 , , , cord-270528-3rsv3jlh 66 18 28 28 CD cord-270528-3rsv3jlh 66 19 ) ) -RRB- cord-270528-3rsv3jlh 66 20 . . . cord-270528-3rsv3jlh 67 1 Similar similar JJ cord-270528-3rsv3jlh 67 2 to to IN cord-270528-3rsv3jlh 67 3 all all DT cord-270528-3rsv3jlh 67 4 infectious infectious JJ cord-270528-3rsv3jlh 67 5 diseases disease NNS cord-270528-3rsv3jlh 67 6 , , , cord-270528-3rsv3jlh 67 7 the the DT cord-270528-3rsv3jlh 67 8 immune immune JJ cord-270528-3rsv3jlh 67 9 system system NN cord-270528-3rsv3jlh 67 10 plays play VBZ cord-270528-3rsv3jlh 67 11 an an DT cord-270528-3rsv3jlh 67 12 essential essential JJ cord-270528-3rsv3jlh 67 13 role role NN cord-270528-3rsv3jlh 67 14 in in IN cord-270528-3rsv3jlh 67 15 virus virus NN cord-270528-3rsv3jlh 67 16 suppression suppression NN cord-270528-3rsv3jlh 67 17 . . . cord-270528-3rsv3jlh 68 1 Therefore therefore RB cord-270528-3rsv3jlh 68 2 , , , cord-270528-3rsv3jlh 68 3 it -PRON- PRP cord-270528-3rsv3jlh 68 4 can can MD cord-270528-3rsv3jlh 68 5 be be VB cord-270528-3rsv3jlh 68 6 assumed assume VBN cord-270528-3rsv3jlh 68 7 that that IN cord-270528-3rsv3jlh 68 8 suppression suppression NN cord-270528-3rsv3jlh 68 9 of of IN cord-270528-3rsv3jlh 68 10 the the DT cord-270528-3rsv3jlh 68 11 immune immune JJ cord-270528-3rsv3jlh 68 12 defense defense NN cord-270528-3rsv3jlh 68 13 system system NN cord-270528-3rsv3jlh 68 14 will will MD cord-270528-3rsv3jlh 68 15 make make VB cord-270528-3rsv3jlh 68 16 the the DT cord-270528-3rsv3jlh 68 17 situation situation NN cord-270528-3rsv3jlh 68 18 worse bad JJR cord-270528-3rsv3jlh 68 19 , , , cord-270528-3rsv3jlh 68 20 but but CC cord-270528-3rsv3jlh 68 21 it -PRON- PRP cord-270528-3rsv3jlh 68 22 is be VBZ cord-270528-3rsv3jlh 68 23 not not RB cord-270528-3rsv3jlh 68 24 as as RB cord-270528-3rsv3jlh 68 25 simple simple JJ cord-270528-3rsv3jlh 68 26 as as IN cord-270528-3rsv3jlh 68 27 it -PRON- PRP cord-270528-3rsv3jlh 68 28 sounds sound VBZ cord-270528-3rsv3jlh 68 29 ( ( -LRB- cord-270528-3rsv3jlh 68 30 29 29 CD cord-270528-3rsv3jlh 68 31 ) ) -RRB- cord-270528-3rsv3jlh 68 32 . . . cord-270528-3rsv3jlh 69 1 There there EX cord-270528-3rsv3jlh 69 2 has have VBZ cord-270528-3rsv3jlh 69 3 not not RB cord-270528-3rsv3jlh 69 4 yet yet RB cord-270528-3rsv3jlh 69 5 been be VBN cord-270528-3rsv3jlh 69 6 enough enough JJ cord-270528-3rsv3jlh 69 7 scientific scientific JJ cord-270528-3rsv3jlh 69 8 evidence evidence NN cord-270528-3rsv3jlh 69 9 to to TO cord-270528-3rsv3jlh 69 10 generally generally RB cord-270528-3rsv3jlh 69 11 employ employ VB cord-270528-3rsv3jlh 69 12 immunosuppressive immunosuppressive JJ cord-270528-3rsv3jlh 69 13 drugs drug NNS cord-270528-3rsv3jlh 69 14 in in IN cord-270528-3rsv3jlh 69 15 autoimmune autoimmune JJ cord-270528-3rsv3jlh 69 16 diseases disease NNS cord-270528-3rsv3jlh 69 17 like like IN cord-270528-3rsv3jlh 69 18 rheumatoid rheumatoid NN cord-270528-3rsv3jlh 69 19 arthritis arthritis NN cord-270528-3rsv3jlh 69 20 ( ( -LRB- cord-270528-3rsv3jlh 69 21 RA RA NNP cord-270528-3rsv3jlh 69 22 ) ) -RRB- cord-270528-3rsv3jlh 69 23 ( ( -LRB- cord-270528-3rsv3jlh 69 24 30 30 CD cord-270528-3rsv3jlh 69 25 , , , cord-270528-3rsv3jlh 69 26 31 31 CD cord-270528-3rsv3jlh 69 27 ) ) -RRB- cord-270528-3rsv3jlh 69 28 . . . cord-270528-3rsv3jlh 70 1 On on IN cord-270528-3rsv3jlh 70 2 the the DT cord-270528-3rsv3jlh 70 3 other other JJ cord-270528-3rsv3jlh 70 4 hand hand NN cord-270528-3rsv3jlh 70 5 , , , cord-270528-3rsv3jlh 70 6 the the DT cord-270528-3rsv3jlh 70 7 hyper hyper JJ cord-270528-3rsv3jlh 70 8 - - JJ cord-270528-3rsv3jlh 70 9 inflammatory inflammatory JJ cord-270528-3rsv3jlh 70 10 and and CC cord-270528-3rsv3jlh 70 11 cytokine cytokine NN cord-270528-3rsv3jlh 70 12 release release NN cord-270528-3rsv3jlh 70 13 syndrome syndrome NN cord-270528-3rsv3jlh 70 14 ( ( -LRB- cord-270528-3rsv3jlh 70 15 CRS CRS NNP cord-270528-3rsv3jlh 70 16 ) ) -RRB- cord-270528-3rsv3jlh 70 17 typical typical JJ cord-270528-3rsv3jlh 70 18 of of IN cord-270528-3rsv3jlh 70 19 COVID-19 covid-19 JJ cord-270528-3rsv3jlh 70 20 causes cause NNS cord-270528-3rsv3jlh 70 21 tissue tissue NN cord-270528-3rsv3jlh 70 22 damage damage NN cord-270528-3rsv3jlh 70 23 to to IN cord-270528-3rsv3jlh 70 24 the the DT cord-270528-3rsv3jlh 70 25 lung lung NN cord-270528-3rsv3jlh 70 26 epithelium epithelium NN cord-270528-3rsv3jlh 70 27 and and CC cord-270528-3rsv3jlh 70 28 ARDS ARDS NNP cord-270528-3rsv3jlh 70 29 ( ( -LRB- cord-270528-3rsv3jlh 70 30 32 32 CD cord-270528-3rsv3jlh 70 31 ) ) -RRB- cord-270528-3rsv3jlh 70 32 ; ; : cord-270528-3rsv3jlh 70 33 therefore therefore RB cord-270528-3rsv3jlh 70 34 , , , cord-270528-3rsv3jlh 70 35 immunosuppressive immunosuppressive JJ cord-270528-3rsv3jlh 70 36 drugs drug NNS cord-270528-3rsv3jlh 70 37 may may MD cord-270528-3rsv3jlh 70 38 be be VB cord-270528-3rsv3jlh 70 39 useful useful JJ cord-270528-3rsv3jlh 70 40 as as IN cord-270528-3rsv3jlh 70 41 there there EX cord-270528-3rsv3jlh 70 42 is be VBZ cord-270528-3rsv3jlh 70 43 some some DT cord-270528-3rsv3jlh 70 44 evidence evidence NN cord-270528-3rsv3jlh 70 45 that that IN cord-270528-3rsv3jlh 70 46 an an DT cord-270528-3rsv3jlh 70 47 anti anti JJ cord-270528-3rsv3jlh 70 48 - - JJ cord-270528-3rsv3jlh 70 49 IL-6 il-6 JJ cord-270528-3rsv3jlh 70 50 approach approach NN cord-270528-3rsv3jlh 70 51 is be VBZ cord-270528-3rsv3jlh 70 52 effective effective JJ cord-270528-3rsv3jlh 70 53 in in IN cord-270528-3rsv3jlh 70 54 critically critically RB cord-270528-3rsv3jlh 70 55 ill ill JJ cord-270528-3rsv3jlh 70 56 patients patient NNS cord-270528-3rsv3jlh 70 57 in in IN cord-270528-3rsv3jlh 70 58 the the DT cord-270528-3rsv3jlh 70 59 ICU ICU NNP cord-270528-3rsv3jlh 70 60 ( ( -LRB- cord-270528-3rsv3jlh 70 61 33 33 CD cord-270528-3rsv3jlh 70 62 ) ) -RRB- cord-270528-3rsv3jlh 70 63 . . . cord-270528-3rsv3jlh 71 1 Another another DT cord-270528-3rsv3jlh 71 2 high high JJ cord-270528-3rsv3jlh 71 3 - - HYPH cord-270528-3rsv3jlh 71 4 risk risk NN cord-270528-3rsv3jlh 71 5 group group NN cord-270528-3rsv3jlh 71 6 for for IN cord-270528-3rsv3jlh 71 7 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 71 8 is be VBZ cord-270528-3rsv3jlh 71 9 cancer cancer NN cord-270528-3rsv3jlh 71 10 patients patient NNS cord-270528-3rsv3jlh 71 11 , , , cord-270528-3rsv3jlh 71 12 who who WP cord-270528-3rsv3jlh 71 13 are be VBP cord-270528-3rsv3jlh 71 14 administered administer VBN cord-270528-3rsv3jlh 71 15 cytotoxic cytotoxic JJ cord-270528-3rsv3jlh 71 16 drugs drug NNS cord-270528-3rsv3jlh 71 17 . . . cord-270528-3rsv3jlh 72 1 Although although IN cord-270528-3rsv3jlh 72 2 their -PRON- PRP$ cord-270528-3rsv3jlh 72 3 immune immune JJ cord-270528-3rsv3jlh 72 4 function function NN cord-270528-3rsv3jlh 72 5 may may MD cord-270528-3rsv3jlh 72 6 be be VB cord-270528-3rsv3jlh 72 7 at at IN cord-270528-3rsv3jlh 72 8 an an DT cord-270528-3rsv3jlh 72 9 acceptable acceptable JJ cord-270528-3rsv3jlh 72 10 level level NN cord-270528-3rsv3jlh 72 11 , , , cord-270528-3rsv3jlh 72 12 some some DT cord-270528-3rsv3jlh 72 13 cytotoxic cytotoxic JJ cord-270528-3rsv3jlh 72 14 drugs drug NNS cord-270528-3rsv3jlh 72 15 such such JJ cord-270528-3rsv3jlh 72 16 as as IN cord-270528-3rsv3jlh 72 17 6-MP 6-mp CD cord-270528-3rsv3jlh 72 18 used use VBN cord-270528-3rsv3jlh 72 19 in in IN cord-270528-3rsv3jlh 72 20 chemotherapy chemotherapy NN cord-270528-3rsv3jlh 72 21 , , , cord-270528-3rsv3jlh 72 22 have have VBP cord-270528-3rsv3jlh 72 23 shown show VBN cord-270528-3rsv3jlh 72 24 destructive destructive JJ cord-270528-3rsv3jlh 72 25 effects effect NNS cord-270528-3rsv3jlh 72 26 on on IN cord-270528-3rsv3jlh 72 27 virus virus NN cord-270528-3rsv3jlh 72 28 replication replication NN cord-270528-3rsv3jlh 72 29 in in IN cord-270528-3rsv3jlh 72 30 vitro vitro FW cord-270528-3rsv3jlh 72 31 ( ( -LRB- cord-270528-3rsv3jlh 72 32 31 31 CD cord-270528-3rsv3jlh 72 33 ) ) -RRB- cord-270528-3rsv3jlh 72 34 . . . cord-270528-3rsv3jlh 73 1 On on IN cord-270528-3rsv3jlh 73 2 the the DT cord-270528-3rsv3jlh 73 3 other other JJ cord-270528-3rsv3jlh 73 4 hand hand NN cord-270528-3rsv3jlh 73 5 , , , cord-270528-3rsv3jlh 73 6 the the DT cord-270528-3rsv3jlh 73 7 high high JJ cord-270528-3rsv3jlh 73 8 number number NN cord-270528-3rsv3jlh 73 9 of of IN cord-270528-3rsv3jlh 73 10 critically critically RB cord-270528-3rsv3jlh 73 11 ill ill JJ cord-270528-3rsv3jlh 73 12 patients patient NNS cord-270528-3rsv3jlh 73 13 and and CC cord-270528-3rsv3jlh 73 14 increased increase VBN cord-270528-3rsv3jlh 73 15 mortality mortality NN cord-270528-3rsv3jlh 73 16 in in IN cord-270528-3rsv3jlh 73 17 patients patient NNS cord-270528-3rsv3jlh 73 18 with with IN cord-270528-3rsv3jlh 73 19 underlying underlie VBG cord-270528-3rsv3jlh 73 20 diseases disease NNS cord-270528-3rsv3jlh 73 21 ( ( -LRB- cord-270528-3rsv3jlh 73 22 such such JJ cord-270528-3rsv3jlh 73 23 as as IN cord-270528-3rsv3jlh 73 24 hypertension hypertension NN cord-270528-3rsv3jlh 73 25 and and CC cord-270528-3rsv3jlh 73 26 diabetes diabetes NN cord-270528-3rsv3jlh 73 27 ) ) -RRB- cord-270528-3rsv3jlh 73 28 has have VBZ cord-270528-3rsv3jlh 73 29 been be VBN cord-270528-3rsv3jlh 73 30 proven prove VBN cord-270528-3rsv3jlh 73 31 ( ( -LRB- cord-270528-3rsv3jlh 73 32 34 34 CD cord-270528-3rsv3jlh 73 33 ) ) -RRB- cord-270528-3rsv3jlh 73 34 . . . cord-270528-3rsv3jlh 74 1 Diabetes diabetes NN cord-270528-3rsv3jlh 74 2 mellitus mellitus NN cord-270528-3rsv3jlh 74 3 type type NN cord-270528-3rsv3jlh 74 4 II II NNP cord-270528-3rsv3jlh 74 5 can can MD cord-270528-3rsv3jlh 74 6 include include VB cord-270528-3rsv3jlh 74 7 a a DT cord-270528-3rsv3jlh 74 8 hyperinflammatory hyperinflammatory JJ cord-270528-3rsv3jlh 74 9 state state NN cord-270528-3rsv3jlh 74 10 with with IN cord-270528-3rsv3jlh 74 11 a a DT cord-270528-3rsv3jlh 74 12 low low JJ cord-270528-3rsv3jlh 74 13 - - HYPH cord-270528-3rsv3jlh 74 14 grade grade NN cord-270528-3rsv3jlh 74 15 inflammatory inflammatory JJ cord-270528-3rsv3jlh 74 16 activity activity NN cord-270528-3rsv3jlh 74 17 that that WDT cord-270528-3rsv3jlh 74 18 causes cause VBZ cord-270528-3rsv3jlh 74 19 long long JJ cord-270528-3rsv3jlh 74 20 - - HYPH cord-270528-3rsv3jlh 74 21 term term NN cord-270528-3rsv3jlh 74 22 immune immune JJ cord-270528-3rsv3jlh 74 23 system system NN cord-270528-3rsv3jlh 74 24 stimulation stimulation NN cord-270528-3rsv3jlh 74 25 ( ( -LRB- cord-270528-3rsv3jlh 74 26 35 35 CD cord-270528-3rsv3jlh 74 27 ) ) -RRB- cord-270528-3rsv3jlh 74 28 , , , cord-270528-3rsv3jlh 74 29 along along IN cord-270528-3rsv3jlh 74 30 with with IN cord-270528-3rsv3jlh 74 31 adipose adipose JJ cord-270528-3rsv3jlh 74 32 tissue tissue NN cord-270528-3rsv3jlh 74 33 side side NN cord-270528-3rsv3jlh 74 34 effects effect NNS cord-270528-3rsv3jlh 74 35 J J NNP cord-270528-3rsv3jlh 74 36 o o NN cord-270528-3rsv3jlh 74 37 u u NN cord-270528-3rsv3jlh 74 38 r r NN cord-270528-3rsv3jlh 74 39 n n NN cord-270528-3rsv3jlh 74 40 a a DT cord-270528-3rsv3jlh 74 41 l l NN cord-270528-3rsv3jlh 74 42 P p NN cord-270528-3rsv3jlh 74 43 r r NN cord-270528-3rsv3jlh 74 44 e e NN cord-270528-3rsv3jlh 74 45 -p -p NN cord-270528-3rsv3jlh 75 1 r r NN cord-270528-3rsv3jlh 75 2 o o NN cord-270528-3rsv3jlh 75 3 o o NN cord-270528-3rsv3jlh 75 4 f f NN cord-270528-3rsv3jlh 75 5 8 8 CD cord-270528-3rsv3jlh 75 6 on on IN cord-270528-3rsv3jlh 75 7 the the DT cord-270528-3rsv3jlh 75 8 immune immune JJ cord-270528-3rsv3jlh 75 9 system system NN cord-270528-3rsv3jlh 75 10 , , , cord-270528-3rsv3jlh 75 11 which which WDT cord-270528-3rsv3jlh 75 12 ultimately ultimately RB cord-270528-3rsv3jlh 75 13 drives drive VBZ cord-270528-3rsv3jlh 75 14 an an DT cord-270528-3rsv3jlh 75 15 immune immune JJ cord-270528-3rsv3jlh 75 16 imbalance imbalance NN cord-270528-3rsv3jlh 75 17 ( ( -LRB- cord-270528-3rsv3jlh 75 18 36 36 CD cord-270528-3rsv3jlh 75 19 ) ) -RRB- cord-270528-3rsv3jlh 75 20 . . . cord-270528-3rsv3jlh 76 1 Also also RB cord-270528-3rsv3jlh 76 2 , , , cord-270528-3rsv3jlh 76 3 due due IN cord-270528-3rsv3jlh 76 4 to to IN cord-270528-3rsv3jlh 76 5 the the DT cord-270528-3rsv3jlh 76 6 overexpression overexpression NN cord-270528-3rsv3jlh 76 7 of of IN cord-270528-3rsv3jlh 76 8 ACE2 ACE2 NNP cord-270528-3rsv3jlh 76 9 in in IN cord-270528-3rsv3jlh 76 10 islet islet NN cord-270528-3rsv3jlh 76 11 cells cell NNS cord-270528-3rsv3jlh 76 12 of of IN cord-270528-3rsv3jlh 76 13 the the DT cord-270528-3rsv3jlh 76 14 pancreas pancrea NNS cord-270528-3rsv3jlh 76 15 , , , cord-270528-3rsv3jlh 76 16 SARS SARS NNP cord-270528-3rsv3jlh 76 17 - - HYPH cord-270528-3rsv3jlh 76 18 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 76 19 may may MD cord-270528-3rsv3jlh 76 20 be be VB cord-270528-3rsv3jlh 76 21 a a DT cord-270528-3rsv3jlh 76 22 diabetogenic diabetogenic NNP cord-270528-3rsv3jlh 76 23 virus virus NN cord-270528-3rsv3jlh 76 24 that that WDT cord-270528-3rsv3jlh 76 25 causes cause VBZ cord-270528-3rsv3jlh 76 26 severe severe JJ cord-270528-3rsv3jlh 76 27 instability instability NN cord-270528-3rsv3jlh 76 28 in in IN cord-270528-3rsv3jlh 76 29 the the DT cord-270528-3rsv3jlh 76 30 blood blood NN cord-270528-3rsv3jlh 76 31 glucose glucose NN cord-270528-3rsv3jlh 76 32 levels level NNS cord-270528-3rsv3jlh 76 33 of of IN cord-270528-3rsv3jlh 76 34 diabetes diabetes NN cord-270528-3rsv3jlh 76 35 patients patient NNS cord-270528-3rsv3jlh 76 36 , , , cord-270528-3rsv3jlh 76 37 which which WDT cord-270528-3rsv3jlh 76 38 worsens worsen VBZ cord-270528-3rsv3jlh 76 39 the the DT cord-270528-3rsv3jlh 76 40 inflammatory inflammatory JJ cord-270528-3rsv3jlh 76 41 imbalance imbalance NN cord-270528-3rsv3jlh 76 42 ( ( -LRB- cord-270528-3rsv3jlh 76 43 37 37 CD cord-270528-3rsv3jlh 76 44 ) ) -RRB- cord-270528-3rsv3jlh 76 45 . . . cord-270528-3rsv3jlh 77 1 As as IN cord-270528-3rsv3jlh 77 2 a a DT cord-270528-3rsv3jlh 77 3 consequence consequence NN cord-270528-3rsv3jlh 77 4 , , , cord-270528-3rsv3jlh 77 5 the the DT cord-270528-3rsv3jlh 77 6 condition condition NN cord-270528-3rsv3jlh 77 7 of of IN cord-270528-3rsv3jlh 77 8 diabetic diabetic JJ cord-270528-3rsv3jlh 77 9 patients patient NNS cord-270528-3rsv3jlh 77 10 can can MD cord-270528-3rsv3jlh 77 11 be be VB cord-270528-3rsv3jlh 77 12 worsened worsen VBN cord-270528-3rsv3jlh 77 13 after after IN cord-270528-3rsv3jlh 77 14 COVID-19 covid-19 JJ cord-270528-3rsv3jlh 77 15 infection infection NN cord-270528-3rsv3jlh 77 16 , , , cord-270528-3rsv3jlh 77 17 as as IN cord-270528-3rsv3jlh 77 18 evidenced evidence VBN cord-270528-3rsv3jlh 77 19 by by IN cord-270528-3rsv3jlh 77 20 the the DT cord-270528-3rsv3jlh 77 21 higher high JJR cord-270528-3rsv3jlh 77 22 levels level NNS cord-270528-3rsv3jlh 77 23 of of IN cord-270528-3rsv3jlh 77 24 multiple multiple JJ cord-270528-3rsv3jlh 77 25 enzymes enzyme NNS cord-270528-3rsv3jlh 77 26 and and CC cord-270528-3rsv3jlh 77 27 inflammatory inflammatory JJ cord-270528-3rsv3jlh 77 28 cytokines cytokine NNS cord-270528-3rsv3jlh 77 29 compared compare VBN cord-270528-3rsv3jlh 77 30 to to IN cord-270528-3rsv3jlh 77 31 nondiabetic nondiabetic JJ cord-270528-3rsv3jlh 77 32 individuals individual NNS cord-270528-3rsv3jlh 77 33 with with IN cord-270528-3rsv3jlh 77 34 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 77 35 pneumonia pneumonia NN cord-270528-3rsv3jlh 77 36 ( ( -LRB- cord-270528-3rsv3jlh 77 37 38 38 CD cord-270528-3rsv3jlh 77 38 ) ) -RRB- cord-270528-3rsv3jlh 77 39 . . . cord-270528-3rsv3jlh 78 1 CD147 CD147 NNP cord-270528-3rsv3jlh 78 2 , , , cord-270528-3rsv3jlh 78 3 also also RB cord-270528-3rsv3jlh 78 4 known know VBN cord-270528-3rsv3jlh 78 5 as as IN cord-270528-3rsv3jlh 78 6 Basigin Basigin NNP cord-270528-3rsv3jlh 78 7 or or CC cord-270528-3rsv3jlh 78 8 extracellular extracellular JJ cord-270528-3rsv3jlh 78 9 matrix matrix NN cord-270528-3rsv3jlh 78 10 metalloproteinase metalloproteinase NN cord-270528-3rsv3jlh 78 11 inducer inducer NN cord-270528-3rsv3jlh 78 12 ( ( -LRB- cord-270528-3rsv3jlh 78 13 EMMPRIN EMMPRIN NNP cord-270528-3rsv3jlh 78 14 ) ) -RRB- cord-270528-3rsv3jlh 78 15 , , , cord-270528-3rsv3jlh 78 16 is be VBZ cord-270528-3rsv3jlh 78 17 also also RB cord-270528-3rsv3jlh 78 18 recognized recognize VBN cord-270528-3rsv3jlh 78 19 as as IN cord-270528-3rsv3jlh 78 20 a a DT cord-270528-3rsv3jlh 78 21 red red JJ cord-270528-3rsv3jlh 78 22 blood blood NN cord-270528-3rsv3jlh 78 23 cell cell NN cord-270528-3rsv3jlh 78 24 ( ( -LRB- cord-270528-3rsv3jlh 78 25 RBC RBC NNP cord-270528-3rsv3jlh 78 26 ) ) -RRB- cord-270528-3rsv3jlh 78 27 receptor receptor NN cord-270528-3rsv3jlh 78 28 for for IN cord-270528-3rsv3jlh 78 29 the the DT cord-270528-3rsv3jlh 78 30 parasite parasite NN cord-270528-3rsv3jlh 78 31 that that WDT cord-270528-3rsv3jlh 78 32 causes cause VBZ cord-270528-3rsv3jlh 78 33 malaria malaria NN cord-270528-3rsv3jlh 78 34 in in IN cord-270528-3rsv3jlh 78 35 humans human NNS cord-270528-3rsv3jlh 78 36 , , , cord-270528-3rsv3jlh 78 37 and and CC cord-270528-3rsv3jlh 78 38 is be VBZ cord-270528-3rsv3jlh 78 39 a a DT cord-270528-3rsv3jlh 78 40 transmembrane transmembrane NN cord-270528-3rsv3jlh 78 41 protein protein NN cord-270528-3rsv3jlh 78 42 of of IN cord-270528-3rsv3jlh 78 43 the the DT cord-270528-3rsv3jlh 78 44 immunoglobulin immunoglobulin NN cord-270528-3rsv3jlh 78 45 family family NN cord-270528-3rsv3jlh 78 46 . . . cord-270528-3rsv3jlh 79 1 Its -PRON- PRP$ cord-270528-3rsv3jlh 79 2 expression expression NN cord-270528-3rsv3jlh 79 3 is be VBZ cord-270528-3rsv3jlh 79 4 induced induce VBN cord-270528-3rsv3jlh 79 5 in in IN cord-270528-3rsv3jlh 79 6 several several JJ cord-270528-3rsv3jlh 79 7 conditions condition NNS cord-270528-3rsv3jlh 79 8 such such JJ cord-270528-3rsv3jlh 79 9 as as IN cord-270528-3rsv3jlh 79 10 asthma asthma NN cord-270528-3rsv3jlh 79 11 , , , cord-270528-3rsv3jlh 79 12 cancer cancer NN cord-270528-3rsv3jlh 79 13 stem stem NN cord-270528-3rsv3jlh 79 14 cells cell NNS cord-270528-3rsv3jlh 79 15 , , , cord-270528-3rsv3jlh 79 16 high high JJ cord-270528-3rsv3jlh 79 17 glucose glucose NN cord-270528-3rsv3jlh 79 18 concentration concentration NN cord-270528-3rsv3jlh 79 19 in in IN cord-270528-3rsv3jlh 79 20 monocytes monocyte NNS cord-270528-3rsv3jlh 79 21 , , , cord-270528-3rsv3jlh 79 22 and and CC cord-270528-3rsv3jlh 79 23 inflammatory inflammatory JJ cord-270528-3rsv3jlh 79 24 processes process NNS cord-270528-3rsv3jlh 79 25 ( ( -LRB- cord-270528-3rsv3jlh 79 26 39 39 CD cord-270528-3rsv3jlh 79 27 ) ) -RRB- cord-270528-3rsv3jlh 79 28 . . . cord-270528-3rsv3jlh 80 1 Wang Wang NNP cord-270528-3rsv3jlh 80 2 et et NNP cord-270528-3rsv3jlh 80 3 al al NNP cord-270528-3rsv3jlh 80 4 . . . cord-270528-3rsv3jlh 81 1 recently recently RB cord-270528-3rsv3jlh 81 2 demonstrated demonstrate VBD cord-270528-3rsv3jlh 81 3 that that IN cord-270528-3rsv3jlh 81 4 the the DT cord-270528-3rsv3jlh 81 5 SARS SARS NNP cord-270528-3rsv3jlh 81 6 - - HYPH cord-270528-3rsv3jlh 81 7 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 81 8 SP SP NNP cord-270528-3rsv3jlh 81 9 also also RB cord-270528-3rsv3jlh 81 10 binds bind VBZ cord-270528-3rsv3jlh 81 11 to to IN cord-270528-3rsv3jlh 81 12 CD147 CD147 NNP cord-270528-3rsv3jlh 81 13 ( ( -LRB- cord-270528-3rsv3jlh 81 14 40 40 CD cord-270528-3rsv3jlh 81 15 ) ) -RRB- cord-270528-3rsv3jlh 81 16 ; ; : cord-270528-3rsv3jlh 81 17 so so CC cord-270528-3rsv3jlh 81 18 , , , cord-270528-3rsv3jlh 81 19 the the DT cord-270528-3rsv3jlh 81 20 immune immune JJ cord-270528-3rsv3jlh 81 21 system system NN cord-270528-3rsv3jlh 81 22 itself -PRON- PRP cord-270528-3rsv3jlh 81 23 could could MD cord-270528-3rsv3jlh 81 24 be be VB cord-270528-3rsv3jlh 81 25 an an DT cord-270528-3rsv3jlh 81 26 entryway entryway NN cord-270528-3rsv3jlh 81 27 for for IN cord-270528-3rsv3jlh 81 28 SARS SARS NNP cord-270528-3rsv3jlh 81 29 - - HYPH cord-270528-3rsv3jlh 81 30 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 81 31 . . . cord-270528-3rsv3jlh 82 1 ( ( -LRB- cord-270528-3rsv3jlh 82 2 27 27 CD cord-270528-3rsv3jlh 82 3 , , , cord-270528-3rsv3jlh 82 4 46 46 CD cord-270528-3rsv3jlh 82 5 ) ) -RRB- cord-270528-3rsv3jlh 82 6 . . . cord-270528-3rsv3jlh 83 1 Although although IN cord-270528-3rsv3jlh 83 2 the the DT cord-270528-3rsv3jlh 83 3 typical typical JJ cord-270528-3rsv3jlh 83 4 MAS MAS NNP cord-270528-3rsv3jlh 83 5 / / SYM cord-270528-3rsv3jlh 83 6 sHLH shlh JJ cord-270528-3rsv3jlh 83 7 pathology pathology NN cord-270528-3rsv3jlh 83 8 that that WDT cord-270528-3rsv3jlh 83 9 occurs occur VBZ cord-270528-3rsv3jlh 83 10 in in IN cord-270528-3rsv3jlh 83 11 immunocompetent immunocompetent JJ cord-270528-3rsv3jlh 83 12 patients patient NNS cord-270528-3rsv3jlh 83 13 , , , cord-270528-3rsv3jlh 83 14 may may MD cord-270528-3rsv3jlh 83 15 also also RB cord-270528-3rsv3jlh 83 16 be be VB cord-270528-3rsv3jlh 83 17 seen see VBN cord-270528-3rsv3jlh 83 18 in in IN cord-270528-3rsv3jlh 83 19 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 83 20 , , , cord-270528-3rsv3jlh 83 21 but but CC cord-270528-3rsv3jlh 83 22 the the DT cord-270528-3rsv3jlh 83 23 differentiation differentiation NN cord-270528-3rsv3jlh 83 24 between between IN cord-270528-3rsv3jlh 83 25 these these DT cord-270528-3rsv3jlh 83 26 two two CD cord-270528-3rsv3jlh 83 27 patterns pattern NNS cord-270528-3rsv3jlh 83 28 is be VBZ cord-270528-3rsv3jlh 83 29 difficult difficult JJ cord-270528-3rsv3jlh 83 30 . . . cord-270528-3rsv3jlh 84 1 Although although IN cord-270528-3rsv3jlh 84 2 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 84 3 has have VBZ cord-270528-3rsv3jlh 84 4 numerous numerous JJ cord-270528-3rsv3jlh 84 5 manifestations manifestation NNS cord-270528-3rsv3jlh 84 6 , , , cord-270528-3rsv3jlh 84 7 lung lung NN cord-270528-3rsv3jlh 84 8 injury injury NN cord-270528-3rsv3jlh 84 9 and and CC cord-270528-3rsv3jlh 84 10 severe severe JJ cord-270528-3rsv3jlh 84 11 respiratory respiratory JJ cord-270528-3rsv3jlh 84 12 failure failure NN cord-270528-3rsv3jlh 84 13 ( ( -LRB- cord-270528-3rsv3jlh 84 14 SRF SRF NNP cord-270528-3rsv3jlh 84 15 ) ) -RRB- cord-270528-3rsv3jlh 84 16 are be VBP cord-270528-3rsv3jlh 84 17 more more RBR cord-270528-3rsv3jlh 84 18 common common JJ cord-270528-3rsv3jlh 84 19 than than IN cord-270528-3rsv3jlh 84 20 others other NNS cord-270528-3rsv3jlh 84 21 . . . cord-270528-3rsv3jlh 85 1 The the DT cord-270528-3rsv3jlh 85 2 cornerstone cornerstone NN cord-270528-3rsv3jlh 85 3 of of IN cord-270528-3rsv3jlh 85 4 this this DT cord-270528-3rsv3jlh 85 5 condition condition NN cord-270528-3rsv3jlh 85 6 is be VBZ cord-270528-3rsv3jlh 85 7 MAS MAS NNP cord-270528-3rsv3jlh 85 8 / / SYM cord-270528-3rsv3jlh 85 9 sHLH shlh JJ cord-270528-3rsv3jlh 85 10 or or CC cord-270528-3rsv3jlh 85 11 immune immune JJ cord-270528-3rsv3jlh 85 12 dysregulation dysregulation NN cord-270528-3rsv3jlh 85 13 . . . cord-270528-3rsv3jlh 86 1 Alveolar alveolar NN cord-270528-3rsv3jlh 86 2 macrophages macrophage NNS cord-270528-3rsv3jlh 86 3 secret secret JJ cord-270528-3rsv3jlh 86 4 IL-6 IL-6 NNP cord-270528-3rsv3jlh 86 5 that that WDT cord-270528-3rsv3jlh 86 6 cause cause VBP cord-270528-3rsv3jlh 86 7 overproduction overproduction NN cord-270528-3rsv3jlh 86 8 of of IN cord-270528-3rsv3jlh 86 9 pro pro JJ cord-270528-3rsv3jlh 86 10 - - JJ cord-270528-3rsv3jlh 86 11 inflammatory inflammatory JJ cord-270528-3rsv3jlh 86 12 cytokines cytokine NNS cord-270528-3rsv3jlh 86 13 by by IN cord-270528-3rsv3jlh 86 14 monocytes monocyte NNS cord-270528-3rsv3jlh 86 15 , , , cord-270528-3rsv3jlh 86 16 and and CC cord-270528-3rsv3jlh 86 17 dysregulation dysregulation NN cord-270528-3rsv3jlh 86 18 of of IN cord-270528-3rsv3jlh 86 19 lymphocytes lymphocyte NNS cord-270528-3rsv3jlh 86 20 , , , cord-270528-3rsv3jlh 86 21 characterized characterize VBN cord-270528-3rsv3jlh 86 22 by by IN cord-270528-3rsv3jlh 86 23 CD4 CD4 NNP cord-270528-3rsv3jlh 86 24 lymphopenia lymphopenia NNP cord-270528-3rsv3jlh 86 25 and and CC cord-270528-3rsv3jlh 86 26 subsequently subsequently RB cord-270528-3rsv3jlh 86 27 B b NN cord-270528-3rsv3jlh 86 28 cell cell NN cord-270528-3rsv3jlh 86 29 lymphopenia lymphopenia NNP cord-270528-3rsv3jlh 86 30 . . . cord-270528-3rsv3jlh 87 1 In in IN cord-270528-3rsv3jlh 87 2 parallel parallel NN cord-270528-3rsv3jlh 87 3 , , , cord-270528-3rsv3jlh 87 4 the the DT cord-270528-3rsv3jlh 87 5 absolute absolute JJ cord-270528-3rsv3jlh 87 6 natural natural JJ cord-270528-3rsv3jlh 87 7 killer killer NN cord-270528-3rsv3jlh 87 8 ( ( -LRB- cord-270528-3rsv3jlh 87 9 NK NK NNP cord-270528-3rsv3jlh 87 10 ) ) -RRB- cord-270528-3rsv3jlh 87 11 cell cell NN cord-270528-3rsv3jlh 87 12 count count NN cord-270528-3rsv3jlh 87 13 is be VBZ cord-270528-3rsv3jlh 87 14 depleted deplete VBN cord-270528-3rsv3jlh 87 15 , , , cord-270528-3rsv3jlh 87 16 probably probably RB cord-270528-3rsv3jlh 87 17 as as IN cord-270528-3rsv3jlh 87 18 a a DT cord-270528-3rsv3jlh 87 19 result result NN cord-270528-3rsv3jlh 87 20 of of IN cord-270528-3rsv3jlh 87 21 the the DT cord-270528-3rsv3jlh 87 22 rapidly rapidly RB cord-270528-3rsv3jlh 87 23 multiplying multiply VBG cord-270528-3rsv3jlh 87 24 virus virus NN cord-270528-3rsv3jlh 87 25 . . . cord-270528-3rsv3jlh 88 1 Moreover moreover RB cord-270528-3rsv3jlh 88 2 , , , cord-270528-3rsv3jlh 88 3 IL-6 IL-6 NNP cord-270528-3rsv3jlh 88 4 decreases decrease VBZ cord-270528-3rsv3jlh 88 5 the the DT cord-270528-3rsv3jlh 88 6 expression expression NN cord-270528-3rsv3jlh 88 7 of of IN cord-270528-3rsv3jlh 88 8 HLA HLA NNP cord-270528-3rsv3jlh 88 9 - - HYPH cord-270528-3rsv3jlh 88 10 DR DR NNP cord-270528-3rsv3jlh 88 11 on on IN cord-270528-3rsv3jlh 88 12 the the DT cord-270528-3rsv3jlh 88 13 membrane membrane NN cord-270528-3rsv3jlh 88 14 and and CC cord-270528-3rsv3jlh 88 15 production production NN cord-270528-3rsv3jlh 88 16 of of IN cord-270528-3rsv3jlh 88 17 IFN IFN NNP cord-270528-3rsv3jlh 88 18 - - HYPH cord-270528-3rsv3jlh 88 19 Ƴ Ƴ NNP cord-270528-3rsv3jlh 88 20 by by IN cord-270528-3rsv3jlh 88 21 CD4 CD4 NNP cord-270528-3rsv3jlh 88 22 cells cell NNS cord-270528-3rsv3jlh 88 23 ( ( -LRB- cord-270528-3rsv3jlh 88 24 4 4 CD cord-270528-3rsv3jlh 88 25 ) ) -RRB- cord-270528-3rsv3jlh 88 26 . . . cord-270528-3rsv3jlh 89 1 In in IN cord-270528-3rsv3jlh 89 2 conclusion conclusion NN cord-270528-3rsv3jlh 89 3 , , , cord-270528-3rsv3jlh 89 4 it -PRON- PRP cord-270528-3rsv3jlh 89 5 seems seem VBZ cord-270528-3rsv3jlh 89 6 that that IN cord-270528-3rsv3jlh 89 7 innate innate JJ cord-270528-3rsv3jlh 89 8 immunity immunity NN cord-270528-3rsv3jlh 89 9 , , , cord-270528-3rsv3jlh 89 10 characterized characterize VBN cord-270528-3rsv3jlh 89 11 by by IN cord-270528-3rsv3jlh 89 12 neutrophils neutrophil NNS cord-270528-3rsv3jlh 89 13 and and CC cord-270528-3rsv3jlh 89 14 proinflammatory proinflammatory JJ cord-270528-3rsv3jlh 89 15 cytokines cytokine NNS cord-270528-3rsv3jlh 89 16 in in IN cord-270528-3rsv3jlh 89 17 the the DT cord-270528-3rsv3jlh 89 18 format format NN cord-270528-3rsv3jlh 89 19 of of IN cord-270528-3rsv3jlh 89 20 the the DT cord-270528-3rsv3jlh 89 21 cytokine cytokine NN cord-270528-3rsv3jlh 89 22 storm storm NN cord-270528-3rsv3jlh 89 23 , , , cord-270528-3rsv3jlh 89 24 is be VBZ cord-270528-3rsv3jlh 89 25 trying try VBG cord-270528-3rsv3jlh 89 26 to to TO cord-270528-3rsv3jlh 89 27 limit limit VB cord-270528-3rsv3jlh 89 28 the the DT cord-270528-3rsv3jlh 89 29 infection infection NN cord-270528-3rsv3jlh 89 30 and and CC cord-270528-3rsv3jlh 89 31 overcome overcome VB cord-270528-3rsv3jlh 89 32 the the DT cord-270528-3rsv3jlh 89 33 virus virus NN cord-270528-3rsv3jlh 89 34 ; ; : cord-270528-3rsv3jlh 89 35 however however RB cord-270528-3rsv3jlh 89 36 , , , cord-270528-3rsv3jlh 89 37 it -PRON- PRP cord-270528-3rsv3jlh 89 38 leads lead VBZ cord-270528-3rsv3jlh 89 39 to to IN cord-270528-3rsv3jlh 89 40 an an DT cord-270528-3rsv3jlh 89 41 excessive excessive JJ cord-270528-3rsv3jlh 89 42 inflammatory inflammatory JJ cord-270528-3rsv3jlh 89 43 response response NN cord-270528-3rsv3jlh 89 44 rather rather RB cord-270528-3rsv3jlh 89 45 than than IN cord-270528-3rsv3jlh 89 46 harming harm VBG cord-270528-3rsv3jlh 89 47 the the DT cord-270528-3rsv3jlh 89 48 virus virus NN cord-270528-3rsv3jlh 89 49 . . . cord-270528-3rsv3jlh 90 1 This this DT cord-270528-3rsv3jlh 90 2 causes cause VBZ cord-270528-3rsv3jlh 90 3 lung lung NN cord-270528-3rsv3jlh 90 4 injury injury NN cord-270528-3rsv3jlh 90 5 with with IN cord-270528-3rsv3jlh 90 6 tissue tissue NN cord-270528-3rsv3jlh 90 7 damage damage NN cord-270528-3rsv3jlh 90 8 and and CC cord-270528-3rsv3jlh 90 9 life life NN cord-270528-3rsv3jlh 90 10 - - HYPH cord-270528-3rsv3jlh 90 11 threatening threaten VBG cord-270528-3rsv3jlh 90 12 edema edema NN cord-270528-3rsv3jlh 90 13 , , , cord-270528-3rsv3jlh 90 14 enriched enrich VBN cord-270528-3rsv3jlh 90 15 with with IN cord-270528-3rsv3jlh 90 16 mucins mucin NNS cord-270528-3rsv3jlh 90 17 and and CC cord-270528-3rsv3jlh 90 18 fibrin fibrin NN cord-270528-3rsv3jlh 90 19 , , , cord-270528-3rsv3jlh 90 20 that that WDT cord-270528-3rsv3jlh 90 21 unfortunately unfortunately RB cord-270528-3rsv3jlh 90 22 causes cause VBZ cord-270528-3rsv3jlh 90 23 SRF SRF NNP cord-270528-3rsv3jlh 90 24 and and CC cord-270528-3rsv3jlh 90 25 death death NN cord-270528-3rsv3jlh 90 26 in in IN cord-270528-3rsv3jlh 90 27 severely severely RB cord-270528-3rsv3jlh 90 28 affected affect VBN cord-270528-3rsv3jlh 90 29 patients patient NNS cord-270528-3rsv3jlh 90 30 ( ( -LRB- cord-270528-3rsv3jlh 90 31 22 22 CD cord-270528-3rsv3jlh 90 32 ) ) -RRB- cord-270528-3rsv3jlh 90 33 . . . cord-270528-3rsv3jlh 91 1 It -PRON- PRP cord-270528-3rsv3jlh 91 2 seems seem VBZ cord-270528-3rsv3jlh 91 3 that that IN cord-270528-3rsv3jlh 91 4 lymphopenia lymphopenia NNP cord-270528-3rsv3jlh 91 5 , , , cord-270528-3rsv3jlh 91 6 hyper hyper JJ cord-270528-3rsv3jlh 91 7 - - JJ cord-270528-3rsv3jlh 91 8 inflammatory inflammatory JJ cord-270528-3rsv3jlh 91 9 state state NN cord-270528-3rsv3jlh 91 10 , , , cord-270528-3rsv3jlh 91 11 and and CC cord-270528-3rsv3jlh 91 12 cytokines cytokine NNS cord-270528-3rsv3jlh 91 13 all all DT cord-270528-3rsv3jlh 91 14 play play VBP cord-270528-3rsv3jlh 91 15 a a DT cord-270528-3rsv3jlh 91 16 role role NN cord-270528-3rsv3jlh 91 17 in in IN cord-270528-3rsv3jlh 91 18 the the DT cord-270528-3rsv3jlh 91 19 pathology pathology NN cord-270528-3rsv3jlh 91 20 of of IN cord-270528-3rsv3jlh 91 21 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 91 22 ; ; : cord-270528-3rsv3jlh 91 23 hence hence RB cord-270528-3rsv3jlh 91 24 the the DT cord-270528-3rsv3jlh 91 25 hypothesis hypothesis NN cord-270528-3rsv3jlh 91 26 was be VBD cord-270528-3rsv3jlh 91 27 proposed propose VBN cord-270528-3rsv3jlh 91 28 that that IN cord-270528-3rsv3jlh 91 29 immunomodulatory immunomodulatory JJ cord-270528-3rsv3jlh 91 30 drugs drug NNS cord-270528-3rsv3jlh 91 31 may may MD cord-270528-3rsv3jlh 91 32 be be VB cord-270528-3rsv3jlh 91 33 beneficial beneficial JJ cord-270528-3rsv3jlh 91 34 to to TO cord-270528-3rsv3jlh 91 35 reverse reverse VB cord-270528-3rsv3jlh 91 36 the the DT cord-270528-3rsv3jlh 91 37 condition condition NN cord-270528-3rsv3jlh 91 38 and and CC cord-270528-3rsv3jlh 91 39 treat treat VB cord-270528-3rsv3jlh 91 40 the the DT cord-270528-3rsv3jlh 91 41 disease disease NN cord-270528-3rsv3jlh 91 42 ( ( -LRB- cord-270528-3rsv3jlh 91 43 47 47 CD cord-270528-3rsv3jlh 91 44 ) ) -RRB- cord-270528-3rsv3jlh 91 45 . . . cord-270528-3rsv3jlh 92 1 Seroconversion seroconversion NN cord-270528-3rsv3jlh 92 2 and and CC cord-270528-3rsv3jlh 92 3 antibody antibody NN cord-270528-3rsv3jlh 92 4 production production NN cord-270528-3rsv3jlh 92 5 occurs occur VBZ cord-270528-3rsv3jlh 92 6 by by IN cord-270528-3rsv3jlh 92 7 the the DT cord-270528-3rsv3jlh 92 8 first first JJ cord-270528-3rsv3jlh 92 9 two two CD cord-270528-3rsv3jlh 92 10 weeks week NNS cord-270528-3rsv3jlh 92 11 after after IN cord-270528-3rsv3jlh 92 12 infection infection NN cord-270528-3rsv3jlh 92 13 ( ( -LRB- cord-270528-3rsv3jlh 92 14 48 48 CD cord-270528-3rsv3jlh 92 15 ) ) -RRB- cord-270528-3rsv3jlh 92 16 . . . cord-270528-3rsv3jlh 93 1 Like like IN cord-270528-3rsv3jlh 93 2 other other JJ cord-270528-3rsv3jlh 93 3 infections infection NNS cord-270528-3rsv3jlh 93 4 , , , cord-270528-3rsv3jlh 93 5 specific specific JJ cord-270528-3rsv3jlh 93 6 IgM IgM NNP cord-270528-3rsv3jlh 93 7 is be VBZ cord-270528-3rsv3jlh 93 8 the the DT cord-270528-3rsv3jlh 93 9 first first JJ cord-270528-3rsv3jlh 93 10 defense defense NN cord-270528-3rsv3jlh 93 11 to to TO cord-270528-3rsv3jlh 93 12 appear appear VB cord-270528-3rsv3jlh 93 13 , , , cord-270528-3rsv3jlh 93 14 and and CC cord-270528-3rsv3jlh 93 15 disappears disappear VBZ cord-270528-3rsv3jlh 93 16 after after IN cord-270528-3rsv3jlh 93 17 a a DT cord-270528-3rsv3jlh 93 18 short short JJ cord-270528-3rsv3jlh 93 19 time time NN cord-270528-3rsv3jlh 93 20 , , , cord-270528-3rsv3jlh 93 21 but but CC cord-270528-3rsv3jlh 93 22 specific specific JJ cord-270528-3rsv3jlh 93 23 IgG igg NN cord-270528-3rsv3jlh 93 24 remains remain VBZ cord-270528-3rsv3jlh 93 25 a a DT cord-270528-3rsv3jlh 93 26 long long JJ cord-270528-3rsv3jlh 93 27 - - HYPH cord-270528-3rsv3jlh 93 28 term term NN cord-270528-3rsv3jlh 93 29 defense defense NN cord-270528-3rsv3jlh 93 30 against against IN cord-270528-3rsv3jlh 93 31 the the DT cord-270528-3rsv3jlh 93 32 virus virus NN cord-270528-3rsv3jlh 93 33 . . . cord-270528-3rsv3jlh 94 1 Therefore therefore RB cord-270528-3rsv3jlh 94 2 , , , cord-270528-3rsv3jlh 94 3 neutralizing neutralize VBG cord-270528-3rsv3jlh 94 4 IgGs IgGs NNP cord-270528-3rsv3jlh 94 5 play play VBP cord-270528-3rsv3jlh 94 6 a a DT cord-270528-3rsv3jlh 94 7 major major JJ cord-270528-3rsv3jlh 94 8 role role NN cord-270528-3rsv3jlh 94 9 in in IN cord-270528-3rsv3jlh 94 10 the the DT cord-270528-3rsv3jlh 94 11 patient patient NN cord-270528-3rsv3jlh 94 12 recovery recovery NN cord-270528-3rsv3jlh 94 13 and and CC cord-270528-3rsv3jlh 94 14 control control NN cord-270528-3rsv3jlh 94 15 of of IN cord-270528-3rsv3jlh 94 16 infection infection NN cord-270528-3rsv3jlh 94 17 . . . cord-270528-3rsv3jlh 95 1 IgGs IgGs NNP cord-270528-3rsv3jlh 95 2 reach reach VBP cord-270528-3rsv3jlh 95 3 their -PRON- PRP$ cord-270528-3rsv3jlh 95 4 peak peak NN cord-270528-3rsv3jlh 95 5 in in IN cord-270528-3rsv3jlh 95 6 the the DT cord-270528-3rsv3jlh 95 7 serum serum NN cord-270528-3rsv3jlh 95 8 during during IN cord-270528-3rsv3jlh 95 9 the the DT cord-270528-3rsv3jlh 95 10 convalescent convalescent JJ cord-270528-3rsv3jlh 95 11 phase phase NN cord-270528-3rsv3jlh 95 12 , , , cord-270528-3rsv3jlh 95 13 and and CC cord-270528-3rsv3jlh 95 14 tend tend VBP cord-270528-3rsv3jlh 95 15 to to TO cord-270528-3rsv3jlh 95 16 wane wane VB cord-270528-3rsv3jlh 95 17 after after IN cord-270528-3rsv3jlh 95 18 recovery recovery NN cord-270528-3rsv3jlh 95 19 , , , cord-270528-3rsv3jlh 95 20 but but CC cord-270528-3rsv3jlh 95 21 memory memory NN cord-270528-3rsv3jlh 95 22 B b NN cord-270528-3rsv3jlh 95 23 cells cell NNS cord-270528-3rsv3jlh 95 24 could could MD cord-270528-3rsv3jlh 95 25 still still RB cord-270528-3rsv3jlh 95 26 survive survive VB cord-270528-3rsv3jlh 95 27 to to TO cord-270528-3rsv3jlh 95 28 offer offer VB cord-270528-3rsv3jlh 95 29 long long JJ cord-270528-3rsv3jlh 95 30 - - HYPH cord-270528-3rsv3jlh 95 31 term term NN cord-270528-3rsv3jlh 95 32 protection protection NN cord-270528-3rsv3jlh 95 33 ( ( -LRB- cord-270528-3rsv3jlh 95 34 22 22 CD cord-270528-3rsv3jlh 95 35 , , , cord-270528-3rsv3jlh 95 36 49 49 CD cord-270528-3rsv3jlh 95 37 ) ) -RRB- cord-270528-3rsv3jlh 95 38 . . . cord-270528-3rsv3jlh 96 1 There there EX cord-270528-3rsv3jlh 96 2 is be VBZ cord-270528-3rsv3jlh 96 3 a a DT cord-270528-3rsv3jlh 96 4 global global JJ cord-270528-3rsv3jlh 96 5 effort effort NN cord-270528-3rsv3jlh 96 6 to to TO cord-270528-3rsv3jlh 96 7 find find VB cord-270528-3rsv3jlh 96 8 an an DT cord-270528-3rsv3jlh 96 9 effective effective JJ cord-270528-3rsv3jlh 96 10 treatment treatment NN cord-270528-3rsv3jlh 96 11 for for IN cord-270528-3rsv3jlh 96 12 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 96 13 . . . cord-270528-3rsv3jlh 97 1 Although although IN cord-270528-3rsv3jlh 97 2 the the DT cord-270528-3rsv3jlh 97 3 benefits benefit NNS cord-270528-3rsv3jlh 97 4 of of IN cord-270528-3rsv3jlh 97 5 some some DT cord-270528-3rsv3jlh 97 6 available available JJ cord-270528-3rsv3jlh 97 7 drugs drug NNS cord-270528-3rsv3jlh 97 8 have have VBP cord-270528-3rsv3jlh 97 9 been be VBN cord-270528-3rsv3jlh 97 10 proven prove VBN cord-270528-3rsv3jlh 97 11 , , , cord-270528-3rsv3jlh 97 12 they -PRON- PRP cord-270528-3rsv3jlh 97 13 are be VBP cord-270528-3rsv3jlh 97 14 not not RB cord-270528-3rsv3jlh 97 15 yet yet RB cord-270528-3rsv3jlh 97 16 a a DT cord-270528-3rsv3jlh 97 17 certain certain JJ cord-270528-3rsv3jlh 97 18 specific specific JJ cord-270528-3rsv3jlh 97 19 cure cure NN cord-270528-3rsv3jlh 97 20 for for IN cord-270528-3rsv3jlh 97 21 the the DT cord-270528-3rsv3jlh 97 22 disease disease NN cord-270528-3rsv3jlh 97 23 , , , cord-270528-3rsv3jlh 97 24 and and CC cord-270528-3rsv3jlh 97 25 controversies controversy NNS cord-270528-3rsv3jlh 97 26 remain remain VBP cord-270528-3rsv3jlh 97 27 ( ( -LRB- cord-270528-3rsv3jlh 97 28 50 50 CD cord-270528-3rsv3jlh 97 29 ) ) -RRB- cord-270528-3rsv3jlh 97 30 . . . cord-270528-3rsv3jlh 98 1 According accord VBG cord-270528-3rsv3jlh 98 2 to to IN cord-270528-3rsv3jlh 98 3 previous previous JJ cord-270528-3rsv3jlh 98 4 experience experience NN cord-270528-3rsv3jlh 98 5 with with IN cord-270528-3rsv3jlh 98 6 other other JJ cord-270528-3rsv3jlh 98 7 coronavirus coronavirus NN cord-270528-3rsv3jlh 98 8 family family NN cord-270528-3rsv3jlh 98 9 members member NNS cord-270528-3rsv3jlh 98 10 , , , cord-270528-3rsv3jlh 98 11 convalescent convalescent JJ cord-270528-3rsv3jlh 98 12 plasma plasma NN cord-270528-3rsv3jlh 98 13 therapy therapy NN cord-270528-3rsv3jlh 98 14 has have VBZ cord-270528-3rsv3jlh 98 15 been be VBN cord-270528-3rsv3jlh 98 16 tested test VBN cord-270528-3rsv3jlh 98 17 on on IN cord-270528-3rsv3jlh 98 18 some some DT cord-270528-3rsv3jlh 98 19 critically critically RB cord-270528-3rsv3jlh 98 20 ill ill JJ cord-270528-3rsv3jlh 98 21 patients patient NNS cord-270528-3rsv3jlh 98 22 , , , cord-270528-3rsv3jlh 98 23 with with IN cord-270528-3rsv3jlh 98 24 _SP cord-270528-3rsv3jlh 98 25 The the DT cord-270528-3rsv3jlh 98 26 worldwide worldwide JJ cord-270528-3rsv3jlh 98 27 economy economy NN cord-270528-3rsv3jlh 98 28 , , , cord-270528-3rsv3jlh 98 29 culture culture NN cord-270528-3rsv3jlh 98 30 , , , cord-270528-3rsv3jlh 98 31 transport transport NN cord-270528-3rsv3jlh 98 32 , , , cord-270528-3rsv3jlh 98 33 sport sport NN cord-270528-3rsv3jlh 98 34 , , , cord-270528-3rsv3jlh 98 35 interpersonal interpersonal JJ cord-270528-3rsv3jlh 98 36 relationships relationship NNS cord-270528-3rsv3jlh 98 37 , , , cord-270528-3rsv3jlh 98 38 education education NN cord-270528-3rsv3jlh 98 39 and and CC cord-270528-3rsv3jlh 98 40 each each DT cord-270528-3rsv3jlh 98 41 individual individual NN cord-270528-3rsv3jlh 98 42 's 's POS cord-270528-3rsv3jlh 98 43 lifestyle lifestyle NN cord-270528-3rsv3jlh 98 44 have have VBP cord-270528-3rsv3jlh 98 45 been be VBN cord-270528-3rsv3jlh 98 46 influenced influence VBN cord-270528-3rsv3jlh 98 47 by by IN cord-270528-3rsv3jlh 98 48 the the DT cord-270528-3rsv3jlh 98 49 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 98 50 pandemic pandemic NN cord-270528-3rsv3jlh 98 51 ( ( -LRB- cord-270528-3rsv3jlh 98 52 57 57 CD cord-270528-3rsv3jlh 98 53 ) ) -RRB- cord-270528-3rsv3jlh 98 54 . . . cord-270528-3rsv3jlh 99 1 However however RB cord-270528-3rsv3jlh 99 2 , , , cord-270528-3rsv3jlh 99 3 the the DT cord-270528-3rsv3jlh 99 4 lethality lethality NN cord-270528-3rsv3jlh 99 5 of of IN cord-270528-3rsv3jlh 99 6 this this DT cord-270528-3rsv3jlh 99 7 virus virus NN cord-270528-3rsv3jlh 99 8 is be VBZ cord-270528-3rsv3jlh 99 9 much much RB cord-270528-3rsv3jlh 99 10 lower low JJR cord-270528-3rsv3jlh 99 11 than than IN cord-270528-3rsv3jlh 99 12 found find VBN cord-270528-3rsv3jlh 99 13 in in IN cord-270528-3rsv3jlh 99 14 previous previous JJ cord-270528-3rsv3jlh 99 15 pandemics pandemic NNS cord-270528-3rsv3jlh 99 16 . . . cord-270528-3rsv3jlh 100 1 What what WP cord-270528-3rsv3jlh 100 2 makes make VBZ cord-270528-3rsv3jlh 100 3 COVID-19 covid-19 VB cord-270528-3rsv3jlh 100 4 so so RB cord-270528-3rsv3jlh 100 5 significant significant JJ cord-270528-3rsv3jlh 100 6 and and CC cord-270528-3rsv3jlh 100 7 dangerous dangerous JJ cord-270528-3rsv3jlh 100 8 , , , cord-270528-3rsv3jlh 100 9 is be VBZ cord-270528-3rsv3jlh 100 10 the the DT cord-270528-3rsv3jlh 100 11 rapid rapid JJ cord-270528-3rsv3jlh 100 12 acceleration acceleration NN cord-270528-3rsv3jlh 100 13 of of IN cord-270528-3rsv3jlh 100 14 the the DT cord-270528-3rsv3jlh 100 15 virus virus NN cord-270528-3rsv3jlh 100 16 transmission transmission NN cord-270528-3rsv3jlh 100 17 . . . cord-270528-3rsv3jlh 101 1 Despite despite IN cord-270528-3rsv3jlh 101 2 all all DT cord-270528-3rsv3jlh 101 3 efforts effort NNS cord-270528-3rsv3jlh 101 4 to to TO cord-270528-3rsv3jlh 101 5 control control VB cord-270528-3rsv3jlh 101 6 and and CC cord-270528-3rsv3jlh 101 7 treat treat VB cord-270528-3rsv3jlh 101 8 this this DT cord-270528-3rsv3jlh 101 9 disease disease NN cord-270528-3rsv3jlh 101 10 , , , cord-270528-3rsv3jlh 101 11 public public JJ cord-270528-3rsv3jlh 101 12 quarantine quarantine NN cord-270528-3rsv3jlh 101 13 and and CC cord-270528-3rsv3jlh 101 14 lockdown lockdown NN cord-270528-3rsv3jlh 101 15 measures measure NNS cord-270528-3rsv3jlh 101 16 can can MD cord-270528-3rsv3jlh 101 17 not not RB cord-270528-3rsv3jlh 101 18 be be VB cord-270528-3rsv3jlh 101 19 implemented implement VBN cord-270528-3rsv3jlh 101 20 for for IN cord-270528-3rsv3jlh 101 21 ever ever RB cord-270528-3rsv3jlh 101 22 , , , cord-270528-3rsv3jlh 101 23 and and CC cord-270528-3rsv3jlh 101 24 all all DT cord-270528-3rsv3jlh 101 25 tested test VBN cord-270528-3rsv3jlh 101 26 treatment treatment NN cord-270528-3rsv3jlh 101 27 methods method NNS cord-270528-3rsv3jlh 101 28 have have VBP cord-270528-3rsv3jlh 101 29 not not RB cord-270528-3rsv3jlh 101 30 been be VBN cord-270528-3rsv3jlh 101 31 sufficiently sufficiently RB cord-270528-3rsv3jlh 101 32 effective effective JJ cord-270528-3rsv3jlh 101 33 . . . cord-270528-3rsv3jlh 102 1 Therefore therefore RB cord-270528-3rsv3jlh 102 2 , , , cord-270528-3rsv3jlh 102 3 along along IN cord-270528-3rsv3jlh 102 4 with with IN cord-270528-3rsv3jlh 102 5 trying try VBG cord-270528-3rsv3jlh 102 6 to to TO cord-270528-3rsv3jlh 102 7 find find VB cord-270528-3rsv3jlh 102 8 more more RBR cord-270528-3rsv3jlh 102 9 effective effective JJ cord-270528-3rsv3jlh 102 10 specific specific JJ cord-270528-3rsv3jlh 102 11 drugs drug NNS cord-270528-3rsv3jlh 102 12 , , , cord-270528-3rsv3jlh 102 13 the the DT cord-270528-3rsv3jlh 102 14 effort effort NN cord-270528-3rsv3jlh 102 15 to to TO cord-270528-3rsv3jlh 102 16 find find VB cord-270528-3rsv3jlh 102 17 a a DT cord-270528-3rsv3jlh 102 18 vaccine vaccine NN cord-270528-3rsv3jlh 102 19 should should MD cord-270528-3rsv3jlh 102 20 be be VB cord-270528-3rsv3jlh 102 21 redoubled redouble VBN cord-270528-3rsv3jlh 102 22 in in IN cord-270528-3rsv3jlh 102 23 order order NN cord-270528-3rsv3jlh 102 24 to to TO cord-270528-3rsv3jlh 102 25 gain gain VB cord-270528-3rsv3jlh 102 26 herd herd NN cord-270528-3rsv3jlh 102 27 immunity immunity NN cord-270528-3rsv3jlh 102 28 and and CC cord-270528-3rsv3jlh 102 29 allow allow VB cord-270528-3rsv3jlh 102 30 the the DT cord-270528-3rsv3jlh 102 31 world world NN cord-270528-3rsv3jlh 102 32 to to TO cord-270528-3rsv3jlh 102 33 return return VB cord-270528-3rsv3jlh 102 34 to to IN cord-270528-3rsv3jlh 102 35 normal normal JJ cord-270528-3rsv3jlh 102 36 life life NN cord-270528-3rsv3jlh 102 37 and and CC cord-270528-3rsv3jlh 102 38 resume resume VB cord-270528-3rsv3jlh 102 39 its -PRON- PRP$ cord-270528-3rsv3jlh 102 40 routine routine NN cord-270528-3rsv3jlh 102 41 . . . cord-270528-3rsv3jlh 103 1 Because because IN cord-270528-3rsv3jlh 103 2 the the DT cord-270528-3rsv3jlh 103 3 process process NN cord-270528-3rsv3jlh 103 4 of of IN cord-270528-3rsv3jlh 103 5 vaccine vaccine NN cord-270528-3rsv3jlh 103 6 preparation preparation NN cord-270528-3rsv3jlh 103 7 and and CC cord-270528-3rsv3jlh 103 8 testing testing NN cord-270528-3rsv3jlh 103 9 is be VBZ cord-270528-3rsv3jlh 103 10 J J NNP cord-270528-3rsv3jlh 104 1 o o UH cord-270528-3rsv3jlh 105 1 u u NNP cord-270528-3rsv3jlh 105 2 r r NNP cord-270528-3rsv3jlh 105 3 n n NN cord-270528-3rsv3jlh 105 4 a a DT cord-270528-3rsv3jlh 105 5 l l NN cord-270528-3rsv3jlh 105 6 P p NN cord-270528-3rsv3jlh 105 7 r r NN cord-270528-3rsv3jlh 105 8 e e NN cord-270528-3rsv3jlh 106 1 -p -p : cord-270528-3rsv3jlh 107 1 r r NN cord-270528-3rsv3jlh 107 2 o o NN cord-270528-3rsv3jlh 107 3 o o NN cord-270528-3rsv3jlh 107 4 f f NN cord-270528-3rsv3jlh 107 5 13 13 CD cord-270528-3rsv3jlh 107 6 complicated complicated JJ cord-270528-3rsv3jlh 107 7 and and CC cord-270528-3rsv3jlh 107 8 lengthy lengthy JJ cord-270528-3rsv3jlh 107 9 , , , cord-270528-3rsv3jlh 107 10 validating validate VBG cord-270528-3rsv3jlh 107 11 and and CC cord-270528-3rsv3jlh 107 12 marketing marketing NN cord-270528-3rsv3jlh 107 13 vaccines vaccine NNS cord-270528-3rsv3jlh 107 14 can can MD cord-270528-3rsv3jlh 107 15 be be VB cord-270528-3rsv3jlh 107 16 tedious tedious JJ cord-270528-3rsv3jlh 107 17 , , , cord-270528-3rsv3jlh 107 18 but but CC cord-270528-3rsv3jlh 107 19 given give VBN cord-270528-3rsv3jlh 107 20 the the DT cord-270528-3rsv3jlh 107 21 body body NN cord-270528-3rsv3jlh 107 22 of of IN cord-270528-3rsv3jlh 107 23 work work NN cord-270528-3rsv3jlh 107 24 by by IN cord-270528-3rsv3jlh 107 25 various various JJ cord-270528-3rsv3jlh 107 26 research research NN cord-270528-3rsv3jlh 107 27 groups group NNS cord-270528-3rsv3jlh 107 28 , , , cord-270528-3rsv3jlh 107 29 there there EX cord-270528-3rsv3jlh 107 30 is be VBZ cord-270528-3rsv3jlh 107 31 a a DT cord-270528-3rsv3jlh 107 32 clear clear JJ cord-270528-3rsv3jlh 107 33 prospect prospect NN cord-270528-3rsv3jlh 107 34 of of IN cord-270528-3rsv3jlh 107 35 achieving achieve VBG cord-270528-3rsv3jlh 107 36 this this DT cord-270528-3rsv3jlh 107 37 goal goal NN cord-270528-3rsv3jlh 107 38 sooner soon RBR cord-270528-3rsv3jlh 107 39 rather rather RB cord-270528-3rsv3jlh 107 40 than than IN cord-270528-3rsv3jlh 107 41 later later RB cord-270528-3rsv3jlh 107 42 ( ( -LRB- cord-270528-3rsv3jlh 107 43 20 20 CD cord-270528-3rsv3jlh 107 44 , , , cord-270528-3rsv3jlh 107 45 58 58 CD cord-270528-3rsv3jlh 107 46 , , , cord-270528-3rsv3jlh 107 47 59 59 CD cord-270528-3rsv3jlh 107 48 ) ) -RRB- cord-270528-3rsv3jlh 107 49 . . . cord-270528-3rsv3jlh 108 1 The the DT cord-270528-3rsv3jlh 108 2 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 108 3 pandemic pandemic NN cord-270528-3rsv3jlh 108 4 is be VBZ cord-270528-3rsv3jlh 108 5 an an DT cord-270528-3rsv3jlh 108 6 ongoing ongoing JJ cord-270528-3rsv3jlh 108 7 issue issue NN cord-270528-3rsv3jlh 108 8 that that WDT cord-270528-3rsv3jlh 108 9 affects affect VBZ cord-270528-3rsv3jlh 108 10 the the DT cord-270528-3rsv3jlh 108 11 lives life NNS cord-270528-3rsv3jlh 108 12 of of IN cord-270528-3rsv3jlh 108 13 most most JJS cord-270528-3rsv3jlh 108 14 people people NNS cord-270528-3rsv3jlh 108 15 around around IN cord-270528-3rsv3jlh 108 16 the the DT cord-270528-3rsv3jlh 108 17 world world NN cord-270528-3rsv3jlh 108 18 . . . cord-270528-3rsv3jlh 109 1 Most Most JJS cord-270528-3rsv3jlh 109 2 countries country NNS cord-270528-3rsv3jlh 109 3 are be VBP cord-270528-3rsv3jlh 109 4 now now RB cord-270528-3rsv3jlh 109 5 semi semi JJ cord-270528-3rsv3jlh 109 6 - - JJ cord-270528-3rsv3jlh 109 7 closed closed JJ cord-270528-3rsv3jlh 109 8 , , , cord-270528-3rsv3jlh 109 9 strict strict JJ cord-270528-3rsv3jlh 109 10 travel travel NN cord-270528-3rsv3jlh 109 11 regulations regulation NNS cord-270528-3rsv3jlh 109 12 have have VBP cord-270528-3rsv3jlh 109 13 been be VBN cord-270528-3rsv3jlh 109 14 enacted enact VBN cord-270528-3rsv3jlh 109 15 , , , cord-270528-3rsv3jlh 109 16 international international JJ cord-270528-3rsv3jlh 109 17 relations relation NNS cord-270528-3rsv3jlh 109 18 have have VBP cord-270528-3rsv3jlh 109 19 been be VBN cord-270528-3rsv3jlh 109 20 affected affect VBN cord-270528-3rsv3jlh 109 21 , , , cord-270528-3rsv3jlh 109 22 and and CC cord-270528-3rsv3jlh 109 23 humans human NNS cord-270528-3rsv3jlh 109 24 are be VBP cord-270528-3rsv3jlh 109 25 experiencing experience VBG cord-270528-3rsv3jlh 109 26 an an DT cord-270528-3rsv3jlh 109 27 unprecedented unprecedented JJ cord-270528-3rsv3jlh 109 28 regime regime NN cord-270528-3rsv3jlh 109 29 , , , cord-270528-3rsv3jlh 109 30 which which WDT cord-270528-3rsv3jlh 109 31 has have VBZ cord-270528-3rsv3jlh 109 32 changed change VBN cord-270528-3rsv3jlh 109 33 ordinary ordinary JJ cord-270528-3rsv3jlh 109 34 life life NN cord-270528-3rsv3jlh 109 35 ( ( -LRB- cord-270528-3rsv3jlh 109 36 60 60 CD cord-270528-3rsv3jlh 109 37 ) ) -RRB- cord-270528-3rsv3jlh 109 38 . . . cord-270528-3rsv3jlh 110 1 Therefore therefore RB cord-270528-3rsv3jlh 110 2 , , , cord-270528-3rsv3jlh 110 3 it -PRON- PRP cord-270528-3rsv3jlh 110 4 is be VBZ cord-270528-3rsv3jlh 110 5 of of IN cord-270528-3rsv3jlh 110 6 the the DT cord-270528-3rsv3jlh 110 7 utmost utmost JJ cord-270528-3rsv3jlh 110 8 importance importance NN cord-270528-3rsv3jlh 110 9 to to TO cord-270528-3rsv3jlh 110 10 understand understand VB cord-270528-3rsv3jlh 110 11 the the DT cord-270528-3rsv3jlh 110 12 pathophysiology pathophysiology NN cord-270528-3rsv3jlh 110 13 of of IN cord-270528-3rsv3jlh 110 14 disease disease NN cord-270528-3rsv3jlh 110 15 and and CC cord-270528-3rsv3jlh 110 16 how how WRB cord-270528-3rsv3jlh 110 17 the the DT cord-270528-3rsv3jlh 110 18 immune immune JJ cord-270528-3rsv3jlh 110 19 response response NN cord-270528-3rsv3jlh 110 20 to to IN cord-270528-3rsv3jlh 110 21 the the DT cord-270528-3rsv3jlh 110 22 pathogen pathogen NN cord-270528-3rsv3jlh 110 23 affects affect VBZ cord-270528-3rsv3jlh 110 24 the the DT cord-270528-3rsv3jlh 110 25 disease disease NN cord-270528-3rsv3jlh 110 26 . . . cord-270528-3rsv3jlh 111 1 Although although IN cord-270528-3rsv3jlh 111 2 the the DT cord-270528-3rsv3jlh 111 3 immune immune JJ cord-270528-3rsv3jlh 111 4 system system NN cord-270528-3rsv3jlh 111 5 plays play VBZ cord-270528-3rsv3jlh 111 6 an an DT cord-270528-3rsv3jlh 111 7 important important JJ cord-270528-3rsv3jlh 111 8 role role NN cord-270528-3rsv3jlh 111 9 in in IN cord-270528-3rsv3jlh 111 10 fighting fight VBG cord-270528-3rsv3jlh 111 11 COVID-19 covid-19 CD cord-270528-3rsv3jlh 111 12 , , , cord-270528-3rsv3jlh 111 13 paradoxically paradoxically RB cord-270528-3rsv3jlh 111 14 it -PRON- PRP cord-270528-3rsv3jlh 111 15 could could MD cord-270528-3rsv3jlh 111 16 also also RB cord-270528-3rsv3jlh 111 17 be be VB cord-270528-3rsv3jlh 111 18 harmful harmful JJ cord-270528-3rsv3jlh 111 19 . . . cord-270528-3rsv3jlh 112 1 Most most RBS cord-270528-3rsv3jlh 112 2 critically critically RB cord-270528-3rsv3jlh 112 3 ill ill VBP cord-270528-3rsv3jlh 112 4 patients patient NNS cord-270528-3rsv3jlh 112 5 in in IN cord-270528-3rsv3jlh 112 6 ICU ICU NNP cord-270528-3rsv3jlh 112 7 , , , cord-270528-3rsv3jlh 112 8 that that WDT cord-270528-3rsv3jlh 112 9 develop develop VBP cord-270528-3rsv3jlh 112 10 ARDS ARDS NNP cord-270528-3rsv3jlh 112 11 , , , cord-270528-3rsv3jlh 112 12 have have VBP cord-270528-3rsv3jlh 112 13 high high JJ cord-270528-3rsv3jlh 112 14 levels level NNS cord-270528-3rsv3jlh 112 15 of of IN cord-270528-3rsv3jlh 112 16 inflammatory inflammatory JJ cord-270528-3rsv3jlh 112 17 cytokines cytokine NNS cord-270528-3rsv3jlh 112 18 in in IN cord-270528-3rsv3jlh 112 19 their -PRON- PRP$ cord-270528-3rsv3jlh 112 20 circulation circulation NN cord-270528-3rsv3jlh 112 21 , , , cord-270528-3rsv3jlh 112 22 known know VBN cord-270528-3rsv3jlh 112 23 as as IN cord-270528-3rsv3jlh 112 24 CRS CRS NNP cord-270528-3rsv3jlh 112 25 . . . cord-270528-3rsv3jlh 113 1 Considering consider VBG cord-270528-3rsv3jlh 113 2 all all PDT cord-270528-3rsv3jlh 113 3 the the DT cord-270528-3rsv3jlh 113 4 reported report VBN cord-270528-3rsv3jlh 113 5 data datum NNS cord-270528-3rsv3jlh 113 6 from from IN cord-270528-3rsv3jlh 113 7 observations observation NNS cord-270528-3rsv3jlh 113 8 and and CC cord-270528-3rsv3jlh 113 9 measurements measurement NNS cord-270528-3rsv3jlh 113 10 , , , cord-270528-3rsv3jlh 113 11 it -PRON- PRP cord-270528-3rsv3jlh 113 12 seems seem VBZ cord-270528-3rsv3jlh 113 13 that that IN cord-270528-3rsv3jlh 113 14 when when WRB cord-270528-3rsv3jlh 113 15 the the DT cord-270528-3rsv3jlh 113 16 immune immune JJ cord-270528-3rsv3jlh 113 17 system system NN cord-270528-3rsv3jlh 113 18 is be VBZ cord-270528-3rsv3jlh 113 19 severely severely RB cord-270528-3rsv3jlh 113 20 damaged damage VBN cord-270528-3rsv3jlh 113 21 and and CC cord-270528-3rsv3jlh 113 22 becomes become VBZ cord-270528-3rsv3jlh 113 23 inefficient inefficient JJ cord-270528-3rsv3jlh 113 24 by by IN cord-270528-3rsv3jlh 113 25 lymphopenia lymphopenia NNP cord-270528-3rsv3jlh 113 26 and and CC cord-270528-3rsv3jlh 113 27 Tex Tex NNP cord-270528-3rsv3jlh 113 28 , , , cord-270528-3rsv3jlh 113 29 it -PRON- PRP cord-270528-3rsv3jlh 113 30 tries try VBZ cord-270528-3rsv3jlh 113 31 to to TO cord-270528-3rsv3jlh 113 32 compensate compensate VB cord-270528-3rsv3jlh 113 33 by by IN cord-270528-3rsv3jlh 113 34 triggering trigger VBG cord-270528-3rsv3jlh 113 35 the the DT cord-270528-3rsv3jlh 113 36 CRS CRS NNP cord-270528-3rsv3jlh 113 37 , , , cord-270528-3rsv3jlh 113 38 which which WDT cord-270528-3rsv3jlh 113 39 could could MD cord-270528-3rsv3jlh 113 40 potentially potentially RB cord-270528-3rsv3jlh 113 41 lead lead VB cord-270528-3rsv3jlh 113 42 to to IN cord-270528-3rsv3jlh 113 43 complications complication NNS cord-270528-3rsv3jlh 113 44 like like IN cord-270528-3rsv3jlh 113 45 ARDS ARDS NNP cord-270528-3rsv3jlh 113 46 and and CC cord-270528-3rsv3jlh 113 47 multi multi JJ cord-270528-3rsv3jlh 113 48 - - JJ cord-270528-3rsv3jlh 113 49 organ organ JJ cord-270528-3rsv3jlh 113 50 failure failure NN cord-270528-3rsv3jlh 113 51 . . . cord-270528-3rsv3jlh 114 1 It -PRON- PRP cord-270528-3rsv3jlh 114 2 is be VBZ cord-270528-3rsv3jlh 114 3 necessary necessary JJ cord-270528-3rsv3jlh 114 4 to to TO cord-270528-3rsv3jlh 114 5 find find VB cord-270528-3rsv3jlh 114 6 efficient efficient JJ cord-270528-3rsv3jlh 114 7 drugs drug NNS cord-270528-3rsv3jlh 114 8 and and CC cord-270528-3rsv3jlh 114 9 vaccines vaccine NNS cord-270528-3rsv3jlh 114 10 to to TO cord-270528-3rsv3jlh 114 11 return return VB cord-270528-3rsv3jlh 114 12 to to IN cord-270528-3rsv3jlh 114 13 the the DT cord-270528-3rsv3jlh 114 14 normal normal JJ cord-270528-3rsv3jlh 114 15 situation situation NN cord-270528-3rsv3jlh 114 16 and and CC cord-270528-3rsv3jlh 114 17 reduce reduce VB cord-270528-3rsv3jlh 114 18 the the DT cord-270528-3rsv3jlh 114 19 mortality mortality NN cord-270528-3rsv3jlh 114 20 rate rate NN cord-270528-3rsv3jlh 114 21 . . . cord-270528-3rsv3jlh 115 1 J J NNP cord-270528-3rsv3jlh 115 2 o o NN cord-270528-3rsv3jlh 115 3 u u NN cord-270528-3rsv3jlh 115 4 r r NN cord-270528-3rsv3jlh 115 5 n n NN cord-270528-3rsv3jlh 115 6 a a DT cord-270528-3rsv3jlh 115 7 l l NN cord-270528-3rsv3jlh 115 8 P p NN cord-270528-3rsv3jlh 115 9 r r NN cord-270528-3rsv3jlh 115 10 e e NN cord-270528-3rsv3jlh 116 1 -p -p : cord-270528-3rsv3jlh 117 1 r r NN cord-270528-3rsv3jlh 117 2 o o NN cord-270528-3rsv3jlh 117 3 o o NN cord-270528-3rsv3jlh 117 4 f f NN cord-270528-3rsv3jlh 117 5 Clinical clinical JJ cord-270528-3rsv3jlh 117 6 features feature NNS cord-270528-3rsv3jlh 117 7 of of IN cord-270528-3rsv3jlh 117 8 patients patient NNS cord-270528-3rsv3jlh 117 9 infected infect VBN cord-270528-3rsv3jlh 117 10 with with IN cord-270528-3rsv3jlh 117 11 2019 2019 CD cord-270528-3rsv3jlh 117 12 novel novel JJ cord-270528-3rsv3jlh 117 13 coronavirus coronavirus NN cord-270528-3rsv3jlh 117 14 in in IN cord-270528-3rsv3jlh 117 15 Wuhan Wuhan NNP cord-270528-3rsv3jlh 117 16 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 117 17 : : : cord-270528-3rsv3jlh 117 18 Developing develop VBG cord-270528-3rsv3jlh 117 19 from from IN cord-270528-3rsv3jlh 117 20 an an DT cord-270528-3rsv3jlh 117 21 outbreak outbreak NN cord-270528-3rsv3jlh 117 22 to to IN cord-270528-3rsv3jlh 117 23 a a DT cord-270528-3rsv3jlh 117 24 pandemic pandemic NN cord-270528-3rsv3jlh 117 25 Cutaneous cutaneous JJ cord-270528-3rsv3jlh 117 26 manifestations manifestation NNS cord-270528-3rsv3jlh 117 27 of of IN cord-270528-3rsv3jlh 117 28 the the DT cord-270528-3rsv3jlh 117 29 Coronavirus Coronavirus NNP cord-270528-3rsv3jlh 117 30 Disease Disease NNP cord-270528-3rsv3jlh 117 31 2019 2019 CD cord-270528-3rsv3jlh 117 32 ( ( -LRB- cord-270528-3rsv3jlh 117 33 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 117 34 ) ) -RRB- cord-270528-3rsv3jlh 117 35 : : : cord-270528-3rsv3jlh 117 36 a a DT cord-270528-3rsv3jlh 117 37 brief brief JJ cord-270528-3rsv3jlh 117 38 review review NN cord-270528-3rsv3jlh 117 39 Complex Complex NNP cord-270528-3rsv3jlh 117 40 Immune Immune NNP cord-270528-3rsv3jlh 117 41 Dysregulation Dysregulation NNP cord-270528-3rsv3jlh 117 42 in in IN cord-270528-3rsv3jlh 117 43 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 117 44 Patients Patients NNPS cord-270528-3rsv3jlh 117 45 with with IN cord-270528-3rsv3jlh 117 46 Severe severe JJ cord-270528-3rsv3jlh 117 47 Respiratory respiratory JJ cord-270528-3rsv3jlh 117 48 Failure failure NN cord-270528-3rsv3jlh 117 49 Coronavirus Coronavirus NNP cord-270528-3rsv3jlh 117 50 Diseases Diseases NNPS cord-270528-3rsv3jlh 117 51 ( ( -LRB- cord-270528-3rsv3jlh 117 52 COVID-19 covid-19 VB cord-270528-3rsv3jlh 117 53 ) ) -RRB- cord-270528-3rsv3jlh 117 54 Current current JJ cord-270528-3rsv3jlh 117 55 Status Status NNP cord-270528-3rsv3jlh 117 56 and and CC cord-270528-3rsv3jlh 117 57 Future Future NNP cord-270528-3rsv3jlh 117 58 Perspectives perspective NNS cord-270528-3rsv3jlh 117 59 : : : cord-270528-3rsv3jlh 118 1 A a DT cord-270528-3rsv3jlh 118 2 Narrative Narrative NNP cord-270528-3rsv3jlh 118 3 Review Review NNP cord-270528-3rsv3jlh 118 4 Central central JJ cord-270528-3rsv3jlh 118 5 nervous nervous JJ cord-270528-3rsv3jlh 118 6 system system NN cord-270528-3rsv3jlh 118 7 involvement involvement NN cord-270528-3rsv3jlh 118 8 in in IN cord-270528-3rsv3jlh 118 9 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 118 10 . . . cord-270528-3rsv3jlh 119 1 Archives archive NNS cord-270528-3rsv3jlh 119 2 of of IN cord-270528-3rsv3jlh 119 3 Medical Medical NNP cord-270528-3rsv3jlh 119 4 Research Research NNP cord-270528-3rsv3jlh 119 5 Serological Serological NNP cord-270528-3rsv3jlh 119 6 Assays Assays NNPS cord-270528-3rsv3jlh 119 7 for for IN cord-270528-3rsv3jlh 119 8 SARS SARS NNP cord-270528-3rsv3jlh 119 9 - - HYPH cord-270528-3rsv3jlh 119 10 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 119 11 Infectious Infectious NNP cord-270528-3rsv3jlh 119 12 Disease Disease NNP cord-270528-3rsv3jlh 119 13 : : : cord-270528-3rsv3jlh 119 14 Benefits benefit NNS cord-270528-3rsv3jlh 119 15 , , , cord-270528-3rsv3jlh 119 16 Limitations Limitations NNPS cord-270528-3rsv3jlh 119 17 and and CC cord-270528-3rsv3jlh 119 18 Perspectives Perspectives NNPS cord-270528-3rsv3jlh 119 19 ACE2 ACE2 NNP cord-270528-3rsv3jlh 119 20 receptor receptor NN cord-270528-3rsv3jlh 119 21 expression expression NN cord-270528-3rsv3jlh 119 22 and and CC cord-270528-3rsv3jlh 119 23 severe severe JJ cord-270528-3rsv3jlh 119 24 acute acute JJ cord-270528-3rsv3jlh 119 25 respiratory respiratory JJ cord-270528-3rsv3jlh 119 26 syndrome syndrome NN cord-270528-3rsv3jlh 119 27 coronavirus coronavirus NN cord-270528-3rsv3jlh 119 28 infection infection NN cord-270528-3rsv3jlh 119 29 depend depend VBP cord-270528-3rsv3jlh 119 30 on on IN cord-270528-3rsv3jlh 119 31 differentiation differentiation NN cord-270528-3rsv3jlh 119 32 of of IN cord-270528-3rsv3jlh 119 33 human human JJ cord-270528-3rsv3jlh 119 34 airway airway NN cord-270528-3rsv3jlh 119 35 epithelia epithelium NNS cord-270528-3rsv3jlh 119 36 COVID-19 covid-19 VBP cord-270528-3rsv3jlh 119 37 affects affect VBZ cord-270528-3rsv3jlh 119 38 healthy healthy JJ cord-270528-3rsv3jlh 119 39 pediatricians pediatrician NNS cord-270528-3rsv3jlh 119 40 more more RBR cord-270528-3rsv3jlh 119 41 than than IN cord-270528-3rsv3jlh 119 42 pediatric pediatric JJ cord-270528-3rsv3jlh 119 43 patients patient NNS cord-270528-3rsv3jlh 120 1 A a DT cord-270528-3rsv3jlh 120 2 human human JJ cord-270528-3rsv3jlh 120 3 homolog homolog NN cord-270528-3rsv3jlh 120 4 of of IN cord-270528-3rsv3jlh 120 5 angiotensinconverting angiotensinconverte VBG cord-270528-3rsv3jlh 120 6 enzyme enzyme NN cord-270528-3rsv3jlh 120 7 . . . cord-270528-3rsv3jlh 121 1 Cloning clone VBG cord-270528-3rsv3jlh 121 2 and and CC cord-270528-3rsv3jlh 121 3 functional functional JJ cord-270528-3rsv3jlh 121 4 expression expression NN cord-270528-3rsv3jlh 121 5 as as IN cord-270528-3rsv3jlh 121 6 a a DT cord-270528-3rsv3jlh 121 7 captopril captopril NN cord-270528-3rsv3jlh 121 8 - - HYPH cord-270528-3rsv3jlh 121 9 insensitive insensitive JJ cord-270528-3rsv3jlh 121 10 carboxypeptidase carboxypeptidase NN cord-270528-3rsv3jlh 121 11 Epidemiological epidemiological JJ cord-270528-3rsv3jlh 121 12 and and CC cord-270528-3rsv3jlh 121 13 clinical clinical JJ cord-270528-3rsv3jlh 121 14 characteristics characteristic NNS cord-270528-3rsv3jlh 121 15 of of IN cord-270528-3rsv3jlh 121 16 99 99 CD cord-270528-3rsv3jlh 121 17 cases case NNS cord-270528-3rsv3jlh 121 18 of of IN cord-270528-3rsv3jlh 121 19 2019 2019 CD cord-270528-3rsv3jlh 121 20 novel novel JJ cord-270528-3rsv3jlh 121 21 coronavirus coronavirus NN cord-270528-3rsv3jlh 121 22 pneumonia pneumonia NN cord-270528-3rsv3jlh 121 23 in in IN cord-270528-3rsv3jlh 121 24 Wuhan Wuhan NNP cord-270528-3rsv3jlh 121 25 , , , cord-270528-3rsv3jlh 121 26 China China NNP cord-270528-3rsv3jlh 121 27 : : : cord-270528-3rsv3jlh 121 28 a a DT cord-270528-3rsv3jlh 121 29 descriptive descriptive JJ cord-270528-3rsv3jlh 121 30 study study NN cord-270528-3rsv3jlh 121 31 Immune immune NN cord-270528-3rsv3jlh 121 32 - - HYPH cord-270528-3rsv3jlh 121 33 epidemiological epidemiological JJ cord-270528-3rsv3jlh 121 34 parameters parameter NNS cord-270528-3rsv3jlh 121 35 of of IN cord-270528-3rsv3jlh 121 36 the the DT cord-270528-3rsv3jlh 121 37 novel novel JJ cord-270528-3rsv3jlh 121 38 coronavirus coronavirus NN cord-270528-3rsv3jlh 121 39 -a -a : cord-270528-3rsv3jlh 121 40 perspective perspective NN cord-270528-3rsv3jlh 122 1 A a DT cord-270528-3rsv3jlh 122 2 Current current JJ cord-270528-3rsv3jlh 122 3 Emerging emerge VBG cord-270528-3rsv3jlh 122 4 Respiratory respiratory JJ cord-270528-3rsv3jlh 122 5 Infection infection NN cord-270528-3rsv3jlh 122 6 : : : cord-270528-3rsv3jlh 122 7 Epidemiological epidemiological JJ cord-270528-3rsv3jlh 122 8 and and CC cord-270528-3rsv3jlh 122 9 Clinical Clinical NNP cord-270528-3rsv3jlh 122 10 Characteristics Characteristics NNPS cord-270528-3rsv3jlh 122 11 , , , cord-270528-3rsv3jlh 122 12 Diagnosis Diagnosis NNP cord-270528-3rsv3jlh 122 13 and and CC cord-270528-3rsv3jlh 122 14 Treatments Treatments NNPS cord-270528-3rsv3jlh 122 15 of of IN cord-270528-3rsv3jlh 122 16 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 122 17 The the DT cord-270528-3rsv3jlh 122 18 Lancet Lancet NNP cord-270528-3rsv3jlh 122 19 A a DT cord-270528-3rsv3jlh 122 20 tug tug NN cord-270528-3rsv3jlh 122 21 - - HYPH cord-270528-3rsv3jlh 122 22 of of IN cord-270528-3rsv3jlh 122 23 - - HYPH cord-270528-3rsv3jlh 122 24 war war NN cord-270528-3rsv3jlh 122 25 between between IN cord-270528-3rsv3jlh 122 26 severe severe JJ cord-270528-3rsv3jlh 122 27 acute acute JJ cord-270528-3rsv3jlh 122 28 respiratory respiratory JJ cord-270528-3rsv3jlh 122 29 syndrome syndrome NN cord-270528-3rsv3jlh 122 30 coronavirus coronavirus NN cord-270528-3rsv3jlh 122 31 2 2 CD cord-270528-3rsv3jlh 122 32 and and CC cord-270528-3rsv3jlh 122 33 host host NN cord-270528-3rsv3jlh 122 34 antiviral antiviral JJ cord-270528-3rsv3jlh 122 35 defence defence NN cord-270528-3rsv3jlh 122 36 : : : cord-270528-3rsv3jlh 122 37 lessons lesson NNS cord-270528-3rsv3jlh 122 38 from from IN cord-270528-3rsv3jlh 122 39 other other JJ cord-270528-3rsv3jlh 122 40 pathogenic pathogenic JJ cord-270528-3rsv3jlh 122 41 viruses virus NNS cord-270528-3rsv3jlh 122 42 Tissue tissue NN cord-270528-3rsv3jlh 122 43 distribution distribution NN cord-270528-3rsv3jlh 122 44 of of IN cord-270528-3rsv3jlh 122 45 ACE2 ACE2 NNP cord-270528-3rsv3jlh 122 46 protein protein NN cord-270528-3rsv3jlh 122 47 , , , cord-270528-3rsv3jlh 122 48 the the DT cord-270528-3rsv3jlh 122 49 functional functional JJ cord-270528-3rsv3jlh 122 50 receptor receptor NN cord-270528-3rsv3jlh 122 51 for for IN cord-270528-3rsv3jlh 122 52 SARS SARS NNP cord-270528-3rsv3jlh 122 53 coronavirus coronavirus NN cord-270528-3rsv3jlh 122 54 . . . cord-270528-3rsv3jlh 123 1 A a DT cord-270528-3rsv3jlh 123 2 first first JJ cord-270528-3rsv3jlh 123 3 step step NN cord-270528-3rsv3jlh 123 4 in in IN cord-270528-3rsv3jlh 123 5 understanding understand VBG cord-270528-3rsv3jlh 123 6 SARS SARS NNP cord-270528-3rsv3jlh 123 7 pathogenesis pathogenesis NN cord-270528-3rsv3jlh 123 8 Assessing assess VBG cord-270528-3rsv3jlh 123 9 ACE2 ACE2 NNP cord-270528-3rsv3jlh 123 10 expression expression NN cord-270528-3rsv3jlh 123 11 patterns pattern NNS cord-270528-3rsv3jlh 123 12 in in IN cord-270528-3rsv3jlh 123 13 lung lung NN cord-270528-3rsv3jlh 123 14 tissues tissue NNS cord-270528-3rsv3jlh 123 15 in in IN cord-270528-3rsv3jlh 123 16 the the DT cord-270528-3rsv3jlh 123 17 pathogenesis pathogenesis NN cord-270528-3rsv3jlh 123 18 of of IN cord-270528-3rsv3jlh 123 19 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 123 20 Molecular Molecular NNP cord-270528-3rsv3jlh 123 21 immune immune JJ cord-270528-3rsv3jlh 123 22 pathogenesis pathogenesis NN cord-270528-3rsv3jlh 123 23 and and CC cord-270528-3rsv3jlh 123 24 diagnosis diagnosis NN cord-270528-3rsv3jlh 123 25 of of IN cord-270528-3rsv3jlh 123 26 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 123 27 Vascular Vascular NNP cord-270528-3rsv3jlh 123 28 pharmacology pharmacology NN cord-270528-3rsv3jlh 123 29 of of IN cord-270528-3rsv3jlh 123 30 acute acute JJ cord-270528-3rsv3jlh 123 31 lung lung NN cord-270528-3rsv3jlh 123 32 injury injury NN cord-270528-3rsv3jlh 123 33 and and CC cord-270528-3rsv3jlh 124 1 acute acute JJ cord-270528-3rsv3jlh 124 2 respiratory respiratory JJ cord-270528-3rsv3jlh 124 3 distress distress NN cord-270528-3rsv3jlh 124 4 syndrome syndrome NN cord-270528-3rsv3jlh 124 5 Immune immune JJ cord-270528-3rsv3jlh 124 6 responses response NNS cord-270528-3rsv3jlh 124 7 and and CC cord-270528-3rsv3jlh 124 8 pathogenesis pathogenesis NN cord-270528-3rsv3jlh 124 9 of of IN cord-270528-3rsv3jlh 124 10 SARS SARS NNP cord-270528-3rsv3jlh 124 11 - - : cord-270528-3rsv3jlh 124 12 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 124 13 during during IN cord-270528-3rsv3jlh 124 14 an an DT cord-270528-3rsv3jlh 124 15 outbreak outbreak NN cord-270528-3rsv3jlh 124 16 in in IN cord-270528-3rsv3jlh 124 17 Iran Iran NNP cord-270528-3rsv3jlh 124 18 : : : cord-270528-3rsv3jlh 124 19 Comparison comparison NN cord-270528-3rsv3jlh 124 20 with with IN cord-270528-3rsv3jlh 124 21 SARS SARS NNP cord-270528-3rsv3jlh 124 22 and and CC cord-270528-3rsv3jlh 124 23 MERS MERS NNP cord-270528-3rsv3jlh 124 24 . . . cord-270528-3rsv3jlh 125 1 Reviews review NNS cord-270528-3rsv3jlh 125 2 in in IN cord-270528-3rsv3jlh 125 3 Medical Medical NNP cord-270528-3rsv3jlh 125 4 Virology Virology NNP cord-270528-3rsv3jlh 125 5 Immune Immune NNP cord-270528-3rsv3jlh 125 6 responses response NNS cord-270528-3rsv3jlh 125 7 in in IN cord-270528-3rsv3jlh 125 8 COVID-19 covid-19 JJ cord-270528-3rsv3jlh 125 9 and and CC cord-270528-3rsv3jlh 125 10 potential potential JJ cord-270528-3rsv3jlh 125 11 vaccines vaccine NNS cord-270528-3rsv3jlh 125 12 : : : cord-270528-3rsv3jlh 126 1 Lessons lesson NNS cord-270528-3rsv3jlh 126 2 learned learn VBN cord-270528-3rsv3jlh 126 3 from from IN cord-270528-3rsv3jlh 126 4 SARS SARS NNP cord-270528-3rsv3jlh 126 5 and and CC cord-270528-3rsv3jlh 126 6 MERS MERS NNP cord-270528-3rsv3jlh 126 7 epidemic epidemic NN cord-270528-3rsv3jlh 126 8 Targeting target VBG cord-270528-3rsv3jlh 126 9 potential potential JJ cord-270528-3rsv3jlh 126 10 drivers driver NNS cord-270528-3rsv3jlh 126 11 of of IN cord-270528-3rsv3jlh 126 12 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 126 13 : : : cord-270528-3rsv3jlh 126 14 Neutrophil Neutrophil NNP cord-270528-3rsv3jlh 126 15 extracellular extracellular JJ cord-270528-3rsv3jlh 126 16 traps trap NNS cord-270528-3rsv3jlh 127 1 Coronavirus Coronavirus NNP cord-270528-3rsv3jlh 127 2 infections infection NNS cord-270528-3rsv3jlh 127 3 and and CC cord-270528-3rsv3jlh 127 4 immune immune JJ cord-270528-3rsv3jlh 127 5 responses response NNS cord-270528-3rsv3jlh 127 6 Could Could MD cord-270528-3rsv3jlh 127 7 IL-17 IL-17 NNP cord-270528-3rsv3jlh 127 8 represent represent VB cord-270528-3rsv3jlh 127 9 a a DT cord-270528-3rsv3jlh 127 10 new new JJ cord-270528-3rsv3jlh 127 11 therapeutic therapeutic JJ cord-270528-3rsv3jlh 127 12 target target NN cord-270528-3rsv3jlh 127 13 for for IN cord-270528-3rsv3jlh 127 14 the the DT cord-270528-3rsv3jlh 127 15 treatment treatment NN cord-270528-3rsv3jlh 127 16 and/or and/or CC cord-270528-3rsv3jlh 127 17 management management NN cord-270528-3rsv3jlh 127 18 of of IN cord-270528-3rsv3jlh 127 19 COVID-19-related covid-19-related JJ cord-270528-3rsv3jlh 127 20 respiratory respiratory JJ cord-270528-3rsv3jlh 127 21 syndrome syndrome NN cord-270528-3rsv3jlh 127 22 ? ? . cord-270528-3rsv3jlh 128 1 CoViD-19 CoViD-19 NNP cord-270528-3rsv3jlh 128 2 Immunopathology Immunopathology NNP cord-270528-3rsv3jlh 128 3 & & CC cord-270528-3rsv3jlh 128 4 Immunotherapy Immunotherapy NNP cord-270528-3rsv3jlh 128 5 Reduction Reduction NNP cord-270528-3rsv3jlh 128 6 and and CC cord-270528-3rsv3jlh 128 7 Functional functional JJ cord-270528-3rsv3jlh 128 8 Exhaustion exhaustion NN cord-270528-3rsv3jlh 128 9 of of IN cord-270528-3rsv3jlh 128 10 T T NNP cord-270528-3rsv3jlh 128 11 Cells cell NNS cord-270528-3rsv3jlh 128 12 in in IN cord-270528-3rsv3jlh 128 13 Patients patient NNS cord-270528-3rsv3jlh 128 14 with with IN cord-270528-3rsv3jlh 128 15 Coronavirus Coronavirus NNP cord-270528-3rsv3jlh 128 16 Disease Disease NNP cord-270528-3rsv3jlh 129 1 The the DT cord-270528-3rsv3jlh 129 2 cytokine cytokine NN cord-270528-3rsv3jlh 129 3 release release NN cord-270528-3rsv3jlh 129 4 syndrome syndrome NN cord-270528-3rsv3jlh 129 5 ( ( -LRB- cord-270528-3rsv3jlh 129 6 CRS CRS NNP cord-270528-3rsv3jlh 129 7 ) ) -RRB- cord-270528-3rsv3jlh 129 8 of of IN cord-270528-3rsv3jlh 129 9 severe severe JJ cord-270528-3rsv3jlh 129 10 COVID-19 covid-19 NN cord-270528-3rsv3jlh 129 11 and and CC cord-270528-3rsv3jlh 129 12 Interleukin-6 Interleukin-6 NNP cord-270528-3rsv3jlh 130 1 receptor receptor NN cord-270528-3rsv3jlh 130 2 ( ( -LRB- cord-270528-3rsv3jlh 130 3 IL-6R IL-6R NNP cord-270528-3rsv3jlh 130 4 ) ) -RRB- cord-270528-3rsv3jlh 130 5 antagonist antagonist NN cord-270528-3rsv3jlh 131 1 Tocilizumab Tocilizumab NNP cord-270528-3rsv3jlh 131 2 may may MD cord-270528-3rsv3jlh 131 3 be be VB cord-270528-3rsv3jlh 131 4 the the DT cord-270528-3rsv3jlh 131 5 key key NN cord-270528-3rsv3jlh 131 6 to to TO cord-270528-3rsv3jlh 131 7 reduce reduce VB cord-270528-3rsv3jlh 131 8 the the DT cord-270528-3rsv3jlh 131 9 mortality mortality NN cord-270528-3rsv3jlh 131 10 Hypothesis hypothesis NN cord-270528-3rsv3jlh 131 11 for for IN cord-270528-3rsv3jlh 131 12 potential potential JJ cord-270528-3rsv3jlh 131 13 pathogenesis pathogenesis NN cord-270528-3rsv3jlh 131 14 of of IN cord-270528-3rsv3jlh 131 15 SARS SARS NNP cord-270528-3rsv3jlh 131 16 - - HYPH cord-270528-3rsv3jlh 131 17 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 131 18 infection infection NN cord-270528-3rsv3jlh 131 19 - - : cord-270528-3rsv3jlh 131 20 a a DT cord-270528-3rsv3jlh 131 21 review review NN cord-270528-3rsv3jlh 131 22 of of IN cord-270528-3rsv3jlh 131 23 immune immune JJ cord-270528-3rsv3jlh 131 24 changes change NNS cord-270528-3rsv3jlh 131 25 in in IN cord-270528-3rsv3jlh 131 26 patients patient NNS cord-270528-3rsv3jlh 131 27 with with IN cord-270528-3rsv3jlh 131 28 viral viral JJ cord-270528-3rsv3jlh 131 29 pneumonia pneumonia NN cord-270528-3rsv3jlh 131 30 Lymphopenia Lymphopenia NNP cord-270528-3rsv3jlh 131 31 in in IN cord-270528-3rsv3jlh 131 32 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 131 33 : : : cord-270528-3rsv3jlh 131 34 therapeutic therapeutic JJ cord-270528-3rsv3jlh 131 35 opportunities opportunity NNS cord-270528-3rsv3jlh 132 1 Cell cell NN cord-270528-3rsv3jlh 132 2 Biol Biol NNP cord-270528-3rsv3jlh 132 3 Int Int NNP cord-270528-3rsv3jlh 132 4 Benign Benign NNP cord-270528-3rsv3jlh 132 5 COVID-19 covid-19 NN cord-270528-3rsv3jlh 132 6 in in IN cord-270528-3rsv3jlh 132 7 an an DT cord-270528-3rsv3jlh 132 8 immunocompromised immunocompromised JJ cord-270528-3rsv3jlh 132 9 cancer cancer NN cord-270528-3rsv3jlh 132 10 patientthe patientthe NN cord-270528-3rsv3jlh 132 11 case case NN cord-270528-3rsv3jlh 132 12 of of IN cord-270528-3rsv3jlh 132 13 a a DT cord-270528-3rsv3jlh 132 14 married married JJ cord-270528-3rsv3jlh 132 15 couple couple NN cord-270528-3rsv3jlh 132 16 Rheumatic rheumatic JJ cord-270528-3rsv3jlh 132 17 disease disease NN cord-270528-3rsv3jlh 132 18 and and CC cord-270528-3rsv3jlh 132 19 COVID-19 covid-19 NN cord-270528-3rsv3jlh 132 20 : : : cord-270528-3rsv3jlh 132 21 initial initial JJ cord-270528-3rsv3jlh 132 22 data datum NNS cord-270528-3rsv3jlh 132 23 from from IN cord-270528-3rsv3jlh 132 24 the the DT cord-270528-3rsv3jlh 132 25 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 132 26 Global Global NNP cord-270528-3rsv3jlh 132 27 Rheumatology Rheumatology NNP cord-270528-3rsv3jlh 132 28 Alliance Alliance NNP cord-270528-3rsv3jlh 132 29 provider provider NN cord-270528-3rsv3jlh 132 30 registries registry NNS cord-270528-3rsv3jlh 132 31 . . . cord-270528-3rsv3jlh 133 1 The the DT cord-270528-3rsv3jlh 133 2 Lancet Lancet NNP cord-270528-3rsv3jlh 133 3 Rheumatology Rheumatology NNP cord-270528-3rsv3jlh 133 4 Associations Associations NNPS cord-270528-3rsv3jlh 133 5 between between IN cord-270528-3rsv3jlh 133 6 immunesuppressive immunesuppressive NN cord-270528-3rsv3jlh 133 7 and and CC cord-270528-3rsv3jlh 133 8 stimulating stimulate VBG cord-270528-3rsv3jlh 133 9 drugs drug NNS cord-270528-3rsv3jlh 133 10 and and CC cord-270528-3rsv3jlh 133 11 novel novel JJ cord-270528-3rsv3jlh 133 12 COVID-19-a COVID-19-a NNP cord-270528-3rsv3jlh 133 13 systematic systematic JJ cord-270528-3rsv3jlh 133 14 review review NN cord-270528-3rsv3jlh 133 15 of of IN cord-270528-3rsv3jlh 133 16 current current JJ cord-270528-3rsv3jlh 133 17 evidence evidence NN cord-270528-3rsv3jlh 134 1 On on IN cord-270528-3rsv3jlh 134 2 the the DT cord-270528-3rsv3jlh 134 3 alert alert NN cord-270528-3rsv3jlh 134 4 for for IN cord-270528-3rsv3jlh 134 5 cytokine cytokine JJ cord-270528-3rsv3jlh 134 6 storm storm NN cord-270528-3rsv3jlh 134 7 : : : cord-270528-3rsv3jlh 134 8 Immunopathology immunopathology NN cord-270528-3rsv3jlh 134 9 in in IN cord-270528-3rsv3jlh 134 10 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 134 11 . . . cord-270528-3rsv3jlh 135 1 Arthritis Arthritis NNP cord-270528-3rsv3jlh 135 2 & & CC cord-270528-3rsv3jlh 135 3 Rheumatology Rheumatology NNP cord-270528-3rsv3jlh 136 1 Can Can MD cord-270528-3rsv3jlh 136 2 we -PRON- PRP cord-270528-3rsv3jlh 136 3 use use VB cord-270528-3rsv3jlh 136 4 interleukin-6 interleukin-6 NNP cord-270528-3rsv3jlh 136 5 ( ( -LRB- cord-270528-3rsv3jlh 136 6 IL-6 IL-6 NNP cord-270528-3rsv3jlh 136 7 ) ) -RRB- cord-270528-3rsv3jlh 136 8 blockade blockade NN cord-270528-3rsv3jlh 136 9 for for IN cord-270528-3rsv3jlh 136 10 coronavirus coronavirus NN cord-270528-3rsv3jlh 136 11 disease disease NN cord-270528-3rsv3jlh 136 12 2019 2019 CD cord-270528-3rsv3jlh 136 13 ( ( -LRB- cord-270528-3rsv3jlh 136 14 COVID-19)-induced covid-19)-induce VBN cord-270528-3rsv3jlh 136 15 cytokine cytokine NN cord-270528-3rsv3jlh 136 16 release release NN cord-270528-3rsv3jlh 136 17 syndrome syndrome NN cord-270528-3rsv3jlh 136 18 ( ( -LRB- cord-270528-3rsv3jlh 136 19 CRS CRS NNP cord-270528-3rsv3jlh 136 20 ) ) -RRB- cord-270528-3rsv3jlh 136 21 ? ? . cord-270528-3rsv3jlh 137 1 Comorbid Comorbid NNP cord-270528-3rsv3jlh 137 2 Chronic Chronic NNP cord-270528-3rsv3jlh 137 3 Diseases Diseases NNPS cord-270528-3rsv3jlh 137 4 and and CC cord-270528-3rsv3jlh 137 5 Acute acute JJ cord-270528-3rsv3jlh 137 6 Organ Organ NNP cord-270528-3rsv3jlh 137 7 Injuries Injuries NNPS cord-270528-3rsv3jlh 137 8 Are be VBP cord-270528-3rsv3jlh 137 9 Strongly strongly RB cord-270528-3rsv3jlh 137 10 Correlated correlate VBN cord-270528-3rsv3jlh 137 11 with with IN cord-270528-3rsv3jlh 137 12 Disease Disease NNP cord-270528-3rsv3jlh 137 13 Severity Severity NNP cord-270528-3rsv3jlh 137 14 and and CC cord-270528-3rsv3jlh 137 15 Mortality mortality NN cord-270528-3rsv3jlh 137 16 among among IN cord-270528-3rsv3jlh 137 17 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 137 18 Patients patient NNS cord-270528-3rsv3jlh 137 19 : : : cord-270528-3rsv3jlh 138 1 A a DT cord-270528-3rsv3jlh 138 2 Systemic Systemic NNP cord-270528-3rsv3jlh 138 3 Review Review NNP cord-270528-3rsv3jlh 138 4 and and CC cord-270528-3rsv3jlh 138 5 Meta Meta NNP cord-270528-3rsv3jlh 138 6 - - HYPH cord-270528-3rsv3jlh 138 7 Analysis Analysis NNP cord-270528-3rsv3jlh 138 8 Cells cell NNS cord-270528-3rsv3jlh 138 9 of of IN cord-270528-3rsv3jlh 138 10 innate innate JJ cord-270528-3rsv3jlh 138 11 and and CC cord-270528-3rsv3jlh 138 12 adaptive adaptive JJ cord-270528-3rsv3jlh 138 13 immunity immunity NN cord-270528-3rsv3jlh 138 14 in in IN cord-270528-3rsv3jlh 138 15 type type NN cord-270528-3rsv3jlh 138 16 2 2 CD cord-270528-3rsv3jlh 138 17 diabetes diabete NNS cord-270528-3rsv3jlh 138 18 and and CC cord-270528-3rsv3jlh 138 19 obesity obesity NN cord-270528-3rsv3jlh 138 20 Tissue tissue NN cord-270528-3rsv3jlh 138 21 resident resident NN cord-270528-3rsv3jlh 138 22 macrophages macrophage NNS cord-270528-3rsv3jlh 138 23 : : : cord-270528-3rsv3jlh 138 24 Key key JJ cord-270528-3rsv3jlh 138 25 players player NNS cord-270528-3rsv3jlh 138 26 in in IN cord-270528-3rsv3jlh 138 27 the the DT cord-270528-3rsv3jlh 138 28 pathogenesis pathogenesis NN cord-270528-3rsv3jlh 138 29 of of IN cord-270528-3rsv3jlh 138 30 type type NN cord-270528-3rsv3jlh 138 31 2 2 CD cord-270528-3rsv3jlh 138 32 diabetes diabete NNS cord-270528-3rsv3jlh 138 33 and and CC cord-270528-3rsv3jlh 138 34 its -PRON- PRP$ cord-270528-3rsv3jlh 138 35 complications complication NNS cord-270528-3rsv3jlh 138 36 Binding Binding NNP cord-270528-3rsv3jlh 138 37 of of IN cord-270528-3rsv3jlh 138 38 SARS SARS NNP cord-270528-3rsv3jlh 138 39 coronavirus coronavirus NN cord-270528-3rsv3jlh 138 40 to to IN cord-270528-3rsv3jlh 138 41 its -PRON- PRP$ cord-270528-3rsv3jlh 138 42 receptor receptor NN cord-270528-3rsv3jlh 138 43 damages damage NNS cord-270528-3rsv3jlh 138 44 islets islet NNS cord-270528-3rsv3jlh 138 45 and and CC cord-270528-3rsv3jlh 138 46 causes cause VBZ cord-270528-3rsv3jlh 138 47 acute acute JJ cord-270528-3rsv3jlh 138 48 diabetes diabetes NN cord-270528-3rsv3jlh 138 49 Diabetes diabetes NN cord-270528-3rsv3jlh 138 50 is be VBZ cord-270528-3rsv3jlh 138 51 a a DT cord-270528-3rsv3jlh 138 52 risk risk NN cord-270528-3rsv3jlh 138 53 factor factor NN cord-270528-3rsv3jlh 138 54 for for IN cord-270528-3rsv3jlh 138 55 the the DT cord-270528-3rsv3jlh 138 56 progression progression NN cord-270528-3rsv3jlh 138 57 and and CC cord-270528-3rsv3jlh 138 58 prognosis prognosis NN cord-270528-3rsv3jlh 138 59 of of IN cord-270528-3rsv3jlh 138 60 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 138 61 CD147 CD147 NNP cord-270528-3rsv3jlh 138 62 as as IN cord-270528-3rsv3jlh 138 63 a a DT cord-270528-3rsv3jlh 138 64 Target Target NNP cord-270528-3rsv3jlh 138 65 for for IN cord-270528-3rsv3jlh 138 66 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 138 67 Treatment Treatment NNP cord-270528-3rsv3jlh 138 68 : : : cord-270528-3rsv3jlh 138 69 Suggested suggest VBN cord-270528-3rsv3jlh 138 70 Effects effect NNS cord-270528-3rsv3jlh 138 71 of of IN cord-270528-3rsv3jlh 138 72 Azithromycin Azithromycin NNP cord-270528-3rsv3jlh 138 73 and and CC cord-270528-3rsv3jlh 138 74 Stem Stem NNP cord-270528-3rsv3jlh 138 75 Cell cell NN cord-270528-3rsv3jlh 139 1 Engagement Engagement NNP cord-270528-3rsv3jlh 139 2 SARS SARS NNP cord-270528-3rsv3jlh 139 3 - - HYPH cord-270528-3rsv3jlh 139 4 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 139 5 invades invade VBZ cord-270528-3rsv3jlh 139 6 host host NN cord-270528-3rsv3jlh 139 7 cells cell NNS cord-270528-3rsv3jlh 139 8 via via IN cord-270528-3rsv3jlh 139 9 a a DT cord-270528-3rsv3jlh 139 10 novel novel JJ cord-270528-3rsv3jlh 139 11 route route NN cord-270528-3rsv3jlh 139 12 : : : cord-270528-3rsv3jlh 139 13 CD147-spike cd147-spike JJ cord-270528-3rsv3jlh 139 14 protein protein NN cord-270528-3rsv3jlh 139 15 Relationships relationship NNS cord-270528-3rsv3jlh 139 16 among among IN cord-270528-3rsv3jlh 139 17 lymphocyte lymphocyte NN cord-270528-3rsv3jlh 139 18 subsets subset NNS cord-270528-3rsv3jlh 139 19 , , , cord-270528-3rsv3jlh 139 20 cytokines cytokine NNS cord-270528-3rsv3jlh 139 21 , , , cord-270528-3rsv3jlh 139 22 and and CC cord-270528-3rsv3jlh 139 23 the the DT cord-270528-3rsv3jlh 139 24 pulmonary pulmonary JJ cord-270528-3rsv3jlh 139 25 inflammation inflammation NN cord-270528-3rsv3jlh 139 26 index index NN cord-270528-3rsv3jlh 139 27 in in IN cord-270528-3rsv3jlh 139 28 coronavirus coronavirus NN cord-270528-3rsv3jlh 139 29 ( ( -LRB- cord-270528-3rsv3jlh 139 30 COVID-19 covid-19 VB cord-270528-3rsv3jlh 139 31 ) ) -RRB- cord-270528-3rsv3jlh 139 32 infected infect VBN cord-270528-3rsv3jlh 139 33 patients patient NNS cord-270528-3rsv3jlh 139 34 Longitudinal longitudinal JJ cord-270528-3rsv3jlh 139 35 characteristics characteristic NNS cord-270528-3rsv3jlh 139 36 of of IN cord-270528-3rsv3jlh 139 37 lymphocyte lymphocyte NN cord-270528-3rsv3jlh 139 38 responses response NNS cord-270528-3rsv3jlh 139 39 and and CC cord-270528-3rsv3jlh 139 40 cytokine cytokine NN cord-270528-3rsv3jlh 139 41 profiles profile NNS cord-270528-3rsv3jlh 139 42 in in IN cord-270528-3rsv3jlh 139 43 the the DT cord-270528-3rsv3jlh 139 44 peripheral peripheral JJ cord-270528-3rsv3jlh 139 45 blood blood NN cord-270528-3rsv3jlh 139 46 of of IN cord-270528-3rsv3jlh 139 47 SARS SARS NNP cord-270528-3rsv3jlh 139 48 - - HYPH cord-270528-3rsv3jlh 139 49 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 139 50 infected infect VBN cord-270528-3rsv3jlh 139 51 patients patient NNS cord-270528-3rsv3jlh 139 52 COVID-19 covid-19 VBP cord-270528-3rsv3jlh 139 53 , , , cord-270528-3rsv3jlh 139 54 immune immune JJ cord-270528-3rsv3jlh 139 55 system system NN cord-270528-3rsv3jlh 139 56 response response NN cord-270528-3rsv3jlh 139 57 , , , cord-270528-3rsv3jlh 139 58 hyperinflammation hyperinflammation NN cord-270528-3rsv3jlh 139 59 and and CC cord-270528-3rsv3jlh 139 60 repurposing repurpose VBG cord-270528-3rsv3jlh 139 61 antirheumatic antirheumatic JJ cord-270528-3rsv3jlh 139 62 drugs drug NNS cord-270528-3rsv3jlh 140 1 TH17 TH17 NNP cord-270528-3rsv3jlh 140 2 responses response NNS cord-270528-3rsv3jlh 140 3 in in IN cord-270528-3rsv3jlh 140 4 cytokine cytokine NN cord-270528-3rsv3jlh 140 5 storm storm NN cord-270528-3rsv3jlh 140 6 of of IN cord-270528-3rsv3jlh 140 7 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 140 8 : : : cord-270528-3rsv3jlh 140 9 An an DT cord-270528-3rsv3jlh 140 10 emerging emerge VBG cord-270528-3rsv3jlh 140 11 target target NN cord-270528-3rsv3jlh 140 12 of of IN cord-270528-3rsv3jlh 140 13 JAK2 JAK2 NNP cord-270528-3rsv3jlh 140 14 inhibitor inhibitor NN cord-270528-3rsv3jlh 140 15 Fedratinib Fedratinib NNP cord-270528-3rsv3jlh 140 16 Risk Risk NNP cord-270528-3rsv3jlh 140 17 factors factor NNS cord-270528-3rsv3jlh 140 18 for for IN cord-270528-3rsv3jlh 140 19 severity severity NN cord-270528-3rsv3jlh 140 20 and and CC cord-270528-3rsv3jlh 140 21 mortality mortality NN cord-270528-3rsv3jlh 140 22 in in IN cord-270528-3rsv3jlh 140 23 adult adult NN cord-270528-3rsv3jlh 140 24 COVID-19 covid-19 JJ cord-270528-3rsv3jlh 140 25 inpatients inpatient NNS cord-270528-3rsv3jlh 140 26 in in IN cord-270528-3rsv3jlh 140 27 Wuhan Wuhan NNP cord-270528-3rsv3jlh 141 1 The the DT cord-270528-3rsv3jlh 141 2 Role role NN cord-270528-3rsv3jlh 141 3 of of IN cord-270528-3rsv3jlh 141 4 Cytokines Cytokines NNPS cord-270528-3rsv3jlh 141 5 including include VBG cord-270528-3rsv3jlh 141 6 Interleukin-6 Interleukin-6 NNP cord-270528-3rsv3jlh 141 7 in in IN cord-270528-3rsv3jlh 141 8 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 141 9 induced induce VBN cord-270528-3rsv3jlh 141 10 Pneumonia Pneumonia NNP cord-270528-3rsv3jlh 141 11 and and CC cord-270528-3rsv3jlh 141 12 Macrophage Macrophage NNP cord-270528-3rsv3jlh 141 13 Activation Activation NNP cord-270528-3rsv3jlh 141 14 Syndrome Syndrome NNP cord-270528-3rsv3jlh 141 15 - - HYPH cord-270528-3rsv3jlh 141 16 Like like JJ cord-270528-3rsv3jlh 141 17 Disease Disease NNP cord-270528-3rsv3jlh 142 1 Towards towards IN cord-270528-3rsv3jlh 142 2 treatment treatment NN cord-270528-3rsv3jlh 142 3 planning planning NN cord-270528-3rsv3jlh 142 4 of of IN cord-270528-3rsv3jlh 142 5 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 142 6 : : : cord-270528-3rsv3jlh 142 7 Rationale rationale NN cord-270528-3rsv3jlh 142 8 and and CC cord-270528-3rsv3jlh 142 9 hypothesis hypothesis NN cord-270528-3rsv3jlh 142 10 for for IN cord-270528-3rsv3jlh 142 11 the the DT cord-270528-3rsv3jlh 142 12 use use NN cord-270528-3rsv3jlh 142 13 of of IN cord-270528-3rsv3jlh 142 14 multiple multiple JJ cord-270528-3rsv3jlh 142 15 immunosuppressive immunosuppressive JJ cord-270528-3rsv3jlh 142 16 agents agent NNS cord-270528-3rsv3jlh 142 17 : : : cord-270528-3rsv3jlh 142 18 Anti Anti NNS cord-270528-3rsv3jlh 142 19 - - NNS cord-270528-3rsv3jlh 142 20 antibodies antibody NNS cord-270528-3rsv3jlh 142 21 , , , cord-270528-3rsv3jlh 142 22 immunoglobulins immunoglobulin NNS cord-270528-3rsv3jlh 142 23 , , , cord-270528-3rsv3jlh 142 24 and and CC cord-270528-3rsv3jlh 142 25 corticosteroids corticosteroid NNS cord-270528-3rsv3jlh 142 26 Seroconversion Seroconversion NNP cord-270528-3rsv3jlh 142 27 in in IN cord-270528-3rsv3jlh 142 28 Humans human NNS cord-270528-3rsv3jlh 142 29 : : : cord-270528-3rsv3jlh 142 30 A a DT cord-270528-3rsv3jlh 142 31 Detailed Detailed NNP cord-270528-3rsv3jlh 142 32 Protocol Protocol NNP cord-270528-3rsv3jlh 142 33 for for IN cord-270528-3rsv3jlh 142 34 a a DT cord-270528-3rsv3jlh 142 35 Serological Serological NNP cord-270528-3rsv3jlh 142 36 Assay Assay NNP cord-270528-3rsv3jlh 142 37 , , , cord-270528-3rsv3jlh 142 38 Antigen Antigen NNP cord-270528-3rsv3jlh 142 39 Production Production NNP cord-270528-3rsv3jlh 142 40 , , , cord-270528-3rsv3jlh 142 41 and and CC cord-270528-3rsv3jlh 142 42 Test test NN cord-270528-3rsv3jlh 142 43 Setup Setup NNP cord-270528-3rsv3jlh 142 44 Potent potent JJ cord-270528-3rsv3jlh 142 45 human human JJ cord-270528-3rsv3jlh 142 46 neutralizing neutralize VBG cord-270528-3rsv3jlh 142 47 antibodies antibody NNS cord-270528-3rsv3jlh 142 48 elicited elicit VBN cord-270528-3rsv3jlh 142 49 by by IN cord-270528-3rsv3jlh 142 50 SARS SARS NNP cord-270528-3rsv3jlh 142 51 - - HYPH cord-270528-3rsv3jlh 142 52 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 142 53 infection infection NN cord-270528-3rsv3jlh 143 1 bioRxiv biorxiv RB cord-270528-3rsv3jlh 144 1 Current current JJ cord-270528-3rsv3jlh 144 2 Drugs drug NNS cord-270528-3rsv3jlh 144 3 with with IN cord-270528-3rsv3jlh 144 4 Potential potential NN cord-270528-3rsv3jlh 144 5 for for IN cord-270528-3rsv3jlh 144 6 Treatment Treatment NNP cord-270528-3rsv3jlh 144 7 of of IN cord-270528-3rsv3jlh 144 8 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 144 9 : : : cord-270528-3rsv3jlh 144 10 A a DT cord-270528-3rsv3jlh 144 11 Literature Literature NNP cord-270528-3rsv3jlh 144 12 Review Review NNP cord-270528-3rsv3jlh 144 13 Deployment Deployment NNP cord-270528-3rsv3jlh 144 14 of of IN cord-270528-3rsv3jlh 144 15 convalescent convalescent JJ cord-270528-3rsv3jlh 144 16 plasma plasma NN cord-270528-3rsv3jlh 144 17 for for IN cord-270528-3rsv3jlh 144 18 the the DT cord-270528-3rsv3jlh 144 19 prevention prevention NN cord-270528-3rsv3jlh 144 20 and and CC cord-270528-3rsv3jlh 144 21 treatment treatment NN cord-270528-3rsv3jlh 144 22 of of IN cord-270528-3rsv3jlh 144 23 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 145 1 Could Could MD cord-270528-3rsv3jlh 146 1 Intravenous intravenous JJ cord-270528-3rsv3jlh 146 2 Immunoglobulin immunoglobulin NN cord-270528-3rsv3jlh 146 3 Collected collect VBN cord-270528-3rsv3jlh 146 4 from from IN cord-270528-3rsv3jlh 146 5 Recovered recover VBN cord-270528-3rsv3jlh 146 6 Coronavirus Coronavirus NNP cord-270528-3rsv3jlh 146 7 Patients Patients NNPS cord-270528-3rsv3jlh 146 8 Protect protect VBP cord-270528-3rsv3jlh 146 9 against against IN cord-270528-3rsv3jlh 146 10 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 146 11 and and CC cord-270528-3rsv3jlh 146 12 Strengthen strengthen VB cord-270528-3rsv3jlh 146 13 the the DT cord-270528-3rsv3jlh 146 14 Immune Immune NNP cord-270528-3rsv3jlh 146 15 System System NNP cord-270528-3rsv3jlh 146 16 of of IN cord-270528-3rsv3jlh 146 17 New New NNP cord-270528-3rsv3jlh 146 18 Patients patient NNS cord-270528-3rsv3jlh 146 19 ? ? . cord-270528-3rsv3jlh 147 1 Convalescent Convalescent NNP cord-270528-3rsv3jlh 147 2 Plasma Plasma NNP cord-270528-3rsv3jlh 148 1 to to TO cord-270528-3rsv3jlh 148 2 Treat Treat NNP cord-270528-3rsv3jlh 148 3 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 148 4 Convalescent Convalescent NNP cord-270528-3rsv3jlh 148 5 plasma plasma NN cord-270528-3rsv3jlh 148 6 : : : cord-270528-3rsv3jlh 149 1 A a DT cord-270528-3rsv3jlh 149 2 possible possible JJ cord-270528-3rsv3jlh 149 3 treatment treatment NN cord-270528-3rsv3jlh 149 4 of of IN cord-270528-3rsv3jlh 149 5 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 149 6 in in IN cord-270528-3rsv3jlh 149 7 India India NNP cord-270528-3rsv3jlh 149 8 Treatment Treatment NNP cord-270528-3rsv3jlh 149 9 with with IN cord-270528-3rsv3jlh 149 10 convalescent convalescent JJ cord-270528-3rsv3jlh 149 11 plasma plasma NN cord-270528-3rsv3jlh 149 12 for for IN cord-270528-3rsv3jlh 149 13 COVID-19 covid-19 JJ cord-270528-3rsv3jlh 149 14 patients patient NNS cord-270528-3rsv3jlh 149 15 in in IN cord-270528-3rsv3jlh 149 16 Wuhan Wuhan NNP cord-270528-3rsv3jlh 149 17 A a DT cord-270528-3rsv3jlh 149 18 human human JJ cord-270528-3rsv3jlh 149 19 monoclonal monoclonal JJ cord-270528-3rsv3jlh 149 20 antibody antibody NN cord-270528-3rsv3jlh 149 21 blocking block VBG cord-270528-3rsv3jlh 149 22 SARS SARS NNP cord-270528-3rsv3jlh 149 23 - - HYPH cord-270528-3rsv3jlh 149 24 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 149 25 infection infection NN cord-270528-3rsv3jlh 150 1 Borderless borderless JJ cord-270528-3rsv3jlh 150 2 collaboration collaboration NN cord-270528-3rsv3jlh 150 3 is be VBZ cord-270528-3rsv3jlh 150 4 needed need VBN cord-270528-3rsv3jlh 150 5 for for IN cord-270528-3rsv3jlh 150 6 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 150 7 ; ; : cord-270528-3rsv3jlh 150 8 a a DT cord-270528-3rsv3jlh 150 9 disease disease NN cord-270528-3rsv3jlh 150 10 that that WDT cord-270528-3rsv3jlh 150 11 knows know VBZ cord-270528-3rsv3jlh 150 12 no no DT cord-270528-3rsv3jlh 150 13 borders border NNS cord-270528-3rsv3jlh 150 14 Can Can MD cord-270528-3rsv3jlh 150 15 an an DT cord-270528-3rsv3jlh 150 16 effective effective JJ cord-270528-3rsv3jlh 150 17 SARS SARS NNP cord-270528-3rsv3jlh 150 18 - - HYPH cord-270528-3rsv3jlh 150 19 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 150 20 vaccine vaccine NN cord-270528-3rsv3jlh 150 21 be be VB cord-270528-3rsv3jlh 150 22 developed develop VBN cord-270528-3rsv3jlh 150 23 for for IN cord-270528-3rsv3jlh 150 24 the the DT cord-270528-3rsv3jlh 150 25 older old JJR cord-270528-3rsv3jlh 150 26 population population NN cord-270528-3rsv3jlh 150 27 ? ? . cord-270528-3rsv3jlh 151 1 Progress Progress NNP cord-270528-3rsv3jlh 151 2 and and CC cord-270528-3rsv3jlh 151 3 Prospects Prospects NNPS cord-270528-3rsv3jlh 151 4 on on IN cord-270528-3rsv3jlh 151 5 Vaccine Vaccine NNP cord-270528-3rsv3jlh 151 6 Development Development NNP cord-270528-3rsv3jlh 151 7 against against IN cord-270528-3rsv3jlh 151 8 SARS SARS NNP cord-270528-3rsv3jlh 151 9 - - HYPH cord-270528-3rsv3jlh 151 10 CoV-2 CoV-2 NNP cord-270528-3rsv3jlh 151 11 . . . cord-270528-3rsv3jlh 152 1 Vaccines vaccine NNS cord-270528-3rsv3jlh 152 2 All all DT cord-270528-3rsv3jlh 152 3 together together RB cord-270528-3rsv3jlh 152 4 to to TO cord-270528-3rsv3jlh 152 5 Fight fight VB cord-270528-3rsv3jlh 152 6 Novel Novel NNP cord-270528-3rsv3jlh 152 7 Coronavirus Coronavirus NNP cord-270528-3rsv3jlh 152 8 Disease Disease NNP cord-270528-3rsv3jlh 152 9 ( ( -LRB- cord-270528-3rsv3jlh 152 10 COVID-19 COVID-19 NNP cord-270528-3rsv3jlh 152 11 ) ) -RRB- cord-270528-3rsv3jlh 153 1 The the DT cord-270528-3rsv3jlh 153 2 American American NNP cord-270528-3rsv3jlh 153 3 Journal Journal NNP cord-270528-3rsv3jlh 153 4 of of IN cord-270528-3rsv3jlh 153 5 Tropical Tropical NNP cord-270528-3rsv3jlh 153 6 Medicine Medicine NNP cord-270528-3rsv3jlh 153 7 and and CC cord-270528-3rsv3jlh 153 8 Hygiene Hygiene NNP