id sid tid token lemma pos cord-266948-n7sltd1b 1 1 key key JJ cord-266948-n7sltd1b 2 1 : : : cord-266948-n7sltd1b 2 2 cord-266948-n7sltd1b cord-266948-n7sltd1b NNP cord-266948-n7sltd1b 2 3 authors author NNS cord-266948-n7sltd1b 2 4 : : : cord-266948-n7sltd1b 2 5 Ahamed Ahamed NNP cord-266948-n7sltd1b 2 6 , , , cord-266948-n7sltd1b 2 7 Jasimuddin Jasimuddin NNP cord-266948-n7sltd1b 2 8 title title NN cord-266948-n7sltd1b 2 9 : : : cord-266948-n7sltd1b 3 1 Severe severe JJ cord-266948-n7sltd1b 3 2 aortic aortic JJ cord-266948-n7sltd1b 3 3 stenosis stenosis NN cord-266948-n7sltd1b 3 4 patient patient NN cord-266948-n7sltd1b 3 5 risk risk NN cord-266948-n7sltd1b 3 6 during during IN cord-266948-n7sltd1b 3 7 the the DT cord-266948-n7sltd1b 3 8 COVID-19 COVID-19 NNP cord-266948-n7sltd1b 3 9 pandemic pandemic NN cord-266948-n7sltd1b 3 10 date date NN cord-266948-n7sltd1b 3 11 : : : cord-266948-n7sltd1b 3 12 2020 2020 CD cord-266948-n7sltd1b 3 13 - - HYPH cord-266948-n7sltd1b 3 14 09 09 CD cord-266948-n7sltd1b 3 15 - - SYM cord-266948-n7sltd1b 3 16 14 14 CD cord-266948-n7sltd1b 3 17 journal journal NN cord-266948-n7sltd1b 3 18 : : : cord-266948-n7sltd1b 4 1 Open open JJ cord-266948-n7sltd1b 4 2 Heart heart NN cord-266948-n7sltd1b 4 3 DOI doi NN cord-266948-n7sltd1b 4 4 : : : cord-266948-n7sltd1b 5 1 10.1136 10.1136 CD cord-266948-n7sltd1b 5 2 / / SYM cord-266948-n7sltd1b 5 3 openhrt-2020 openhrt-2020 NN cord-266948-n7sltd1b 5 4 - - HYPH cord-266948-n7sltd1b 5 5 001355 001355 CD cord-266948-n7sltd1b 5 6 sha sha NNP cord-266948-n7sltd1b 5 7 : : : cord-266948-n7sltd1b 5 8 bcfb88f6e5fa21c64d32c6b0a9960e5d58e5b240 bcfb88f6e5fa21c64d32c6b0a9960e5d58e5b240 ADD cord-266948-n7sltd1b 5 9 doc_id doc_id CD cord-266948-n7sltd1b 5 10 : : : cord-266948-n7sltd1b 5 11 266948 266948 CD cord-266948-n7sltd1b 5 12 cord_uid cord_uid NNS cord-266948-n7sltd1b 5 13 : : : cord-266948-n7sltd1b 6 1 n7sltd1b n7sltd1b NNP cord-266948-n7sltd1b 7 1 nan nan NNP cord-266948-n7sltd1b 7 2 SARS SARS NNP cord-266948-n7sltd1b 7 3 - - HYPH cord-266948-n7sltd1b 7 4 CoV-2 CoV-2 NNP cord-266948-n7sltd1b 7 5 infection infection NN cord-266948-n7sltd1b 7 6 can can MD cord-266948-n7sltd1b 7 7 be be VB cord-266948-n7sltd1b 7 8 an an DT cord-266948-n7sltd1b 7 9 additional additional JJ cord-266948-n7sltd1b 7 10 and and CC cord-266948-n7sltd1b 7 11 very very RB cord-266948-n7sltd1b 7 12 dangerous dangerous JJ cord-266948-n7sltd1b 7 13 comorbidity comorbidity NN cord-266948-n7sltd1b 7 14 . . . cord-266948-n7sltd1b 8 1 Therefore therefore RB cord-266948-n7sltd1b 8 2 , , , cord-266948-n7sltd1b 8 3 I -PRON- PRP cord-266948-n7sltd1b 8 4 suggest suggest VBP cord-266948-n7sltd1b 8 5 that that IN cord-266948-n7sltd1b 8 6 the the DT cord-266948-n7sltd1b 8 7 following follow VBG cord-266948-n7sltd1b 8 8 points point NNS cord-266948-n7sltd1b 8 9 should should MD cord-266948-n7sltd1b 8 10 be be VB cord-266948-n7sltd1b 8 11 considered consider VBN cord-266948-n7sltd1b 8 12 : : : cord-266948-n7sltd1b 9 1 1 1 LS cord-266948-n7sltd1b 9 2 . . . cord-266948-n7sltd1b 10 1 Low low JJ cord-266948-n7sltd1b 10 2 - - HYPH cord-266948-n7sltd1b 10 3 risk risk NN cord-266948-n7sltd1b 10 4 , , , cord-266948-n7sltd1b 10 5 asymptomatic asymptomatic JJ cord-266948-n7sltd1b 10 6 patients patient NNS cord-266948-n7sltd1b 10 7 who who WP cord-266948-n7sltd1b 10 8 can can MD cord-266948-n7sltd1b 10 9 delay delay VB cord-266948-n7sltd1b 10 10 their -PRON- PRP$ cord-266948-n7sltd1b 10 11 procedures procedure NNS cord-266948-n7sltd1b 10 12 must must MD cord-266948-n7sltd1b 10 13 stringently stringently RB cord-266948-n7sltd1b 10 14 avoid avoid VB cord-266948-n7sltd1b 10 15 infection infection NN cord-266948-n7sltd1b 10 16 , , , cord-266948-n7sltd1b 10 17 for for IN cord-266948-n7sltd1b 10 18 instance instance NN cord-266948-n7sltd1b 10 19 by by IN cord-266948-n7sltd1b 10 20 following follow VBG cord-266948-n7sltd1b 10 21 guidelines guideline NNS cord-266948-n7sltd1b 10 22 for for IN cord-266948-n7sltd1b 10 23 hygiene hygiene NN cord-266948-n7sltd1b 10 24 and and CC cord-266948-n7sltd1b 10 25 wearing wear VBG cord-266948-n7sltd1b 10 26 masks mask NNS cord-266948-n7sltd1b 10 27 , , , cord-266948-n7sltd1b 10 28 and and CC cord-266948-n7sltd1b 10 29 should should MD cord-266948-n7sltd1b 10 30 continue continue VB cord-266948-n7sltd1b 10 31 to to TO cord-266948-n7sltd1b 10 32 maintain maintain VB cord-266948-n7sltd1b 10 33 strength strength NN cord-266948-n7sltd1b 10 34 and and CC cord-266948-n7sltd1b 10 35 endurance endurance NN cord-266948-n7sltd1b 10 36 as as RB cord-266948-n7sltd1b 10 37 much much RB cord-266948-n7sltd1b 10 38 as as IN cord-266948-n7sltd1b 10 39 possible possible JJ cord-266948-n7sltd1b 10 40 by by IN cord-266948-n7sltd1b 10 41 routine routine JJ cord-266948-n7sltd1b 10 42 exercise exercise NN cord-266948-n7sltd1b 10 43 . . . cord-266948-n7sltd1b 11 1 should should MD cord-266948-n7sltd1b 11 2 discuss discuss VB cord-266948-n7sltd1b 11 3 the the DT cord-266948-n7sltd1b 11 4 potential potential JJ cord-266948-n7sltd1b 11 5 benefits benefit NNS cord-266948-n7sltd1b 11 6 and and CC cord-266948-n7sltd1b 11 7 risks risk NNS cord-266948-n7sltd1b 11 8 , , , cord-266948-n7sltd1b 11 9 including include VBG cord-266948-n7sltd1b 11 10 the the DT cord-266948-n7sltd1b 11 11 new new JJ cord-266948-n7sltd1b 11 12 risk risk NN cord-266948-n7sltd1b 11 13 of of IN cord-266948-n7sltd1b 11 14 comorbidities comorbiditie NNS cord-266948-n7sltd1b 11 15 with with IN cord-266948-n7sltd1b 11 16 COVID-19 COVID-19 NNP cord-266948-n7sltd1b 11 17 that that WDT cord-266948-n7sltd1b 11 18 can can MD cord-266948-n7sltd1b 11 19 be be VB cord-266948-n7sltd1b 11 20 life life NN cord-266948-n7sltd1b 11 21 threatening threaten VBG cord-266948-n7sltd1b 11 22 , , , cord-266948-n7sltd1b 11 23 of of IN cord-266948-n7sltd1b 11 24 hospitalisation hospitalisation NN cord-266948-n7sltd1b 11 25 with with IN cord-266948-n7sltd1b 11 26 their -PRON- PRP$ cord-266948-n7sltd1b 11 27 cardiologists cardiologist NNS cord-266948-n7sltd1b 11 28 . . . cord-266948-n7sltd1b 12 1 Therefore therefore RB cord-266948-n7sltd1b 12 2 , , , cord-266948-n7sltd1b 12 3 physicians physician NNS cord-266948-n7sltd1b 12 4 should should MD cord-266948-n7sltd1b 12 5 have have VB cord-266948-n7sltd1b 12 6 all all DT cord-266948-n7sltd1b 12 7 pertinent pertinent JJ cord-266948-n7sltd1b 12 8 information information NN cord-266948-n7sltd1b 12 9 to to TO cord-266948-n7sltd1b 12 10 identify identify VB cord-266948-n7sltd1b 12 11 the the DT cord-266948-n7sltd1b 12 12 appropriate appropriate JJ cord-266948-n7sltd1b 12 13 procedure procedure NN cord-266948-n7sltd1b 12 14 , , , cord-266948-n7sltd1b 12 15 considering consider VBG cord-266948-n7sltd1b 12 16 both both CC cord-266948-n7sltd1b 12 17 AVR AVR NNP cord-266948-n7sltd1b 12 18 and and CC cord-266948-n7sltd1b 12 19 TAVR TAVR NNP cord-266948-n7sltd1b 12 20 approaches approach NNS cord-266948-n7sltd1b 12 21 . . . cord-266948-n7sltd1b 13 1 The the DT cord-266948-n7sltd1b 13 2 patient patient JJ cord-266948-n7sltd1b 13 3 risk risk NN cord-266948-n7sltd1b 13 4 assessment assessment NN cord-266948-n7sltd1b 13 5 typically typically RB cord-266948-n7sltd1b 13 6 includes include VBZ cord-266948-n7sltd1b 13 7 patient patient JJ cord-266948-n7sltd1b 13 8 age age NN cord-266948-n7sltd1b 13 9 and and CC cord-266948-n7sltd1b 13 10 surgical surgical JJ cord-266948-n7sltd1b 13 11 risk risk NN cord-266948-n7sltd1b 13 12 ; ; : cord-266948-n7sltd1b 13 13 however however RB cord-266948-n7sltd1b 13 14 , , , cord-266948-n7sltd1b 13 15 given give VBN cord-266948-n7sltd1b 13 16 the the DT cord-266948-n7sltd1b 13 17 increased increase VBN cord-266948-n7sltd1b 13 18 general general JJ cord-266948-n7sltd1b 13 19 risk risk NN cord-266948-n7sltd1b 13 20 of of IN cord-266948-n7sltd1b 13 21 the the DT cord-266948-n7sltd1b 13 22 procedure procedure NN cord-266948-n7sltd1b 13 23 and and CC cord-266948-n7sltd1b 13 24 that that IN cord-266948-n7sltd1b 13 25 SARS SARS NNP cord-266948-n7sltd1b 13 26 - - HYPH cord-266948-n7sltd1b 13 27 CoV-2 CoV-2 NNP cord-266948-n7sltd1b 13 28 infection infection NN cord-266948-n7sltd1b 13 29 can can MD cord-266948-n7sltd1b 13 30 be be VB cord-266948-n7sltd1b 13 31 an an DT cord-266948-n7sltd1b 13 32 additional additional JJ cord-266948-n7sltd1b 13 33 and and CC cord-266948-n7sltd1b 13 34 very very RB cord-266948-n7sltd1b 13 35 dangerous dangerous JJ cord-266948-n7sltd1b 13 36 comorbidity comorbidity NN cord-266948-n7sltd1b 13 37 , , , cord-266948-n7sltd1b 13 38 suggesting suggest VBG cord-266948-n7sltd1b 13 39 the the DT cord-266948-n7sltd1b 13 40 less less RBR cord-266948-n7sltd1b 13 41 invasive invasive JJ cord-266948-n7sltd1b 13 42 TAVR TAVR NNP cord-266948-n7sltd1b 13 43 should should MD cord-266948-n7sltd1b 13 44 be be VB cord-266948-n7sltd1b 13 45 considered consider VBN cord-266948-n7sltd1b 13 46 . . . cord-266948-n7sltd1b 14 1 3 3 LS cord-266948-n7sltd1b 14 2 . . . cord-266948-n7sltd1b 15 1 COVID-19 COVID-19 NNP cord-266948-n7sltd1b 15 2 may may MD cord-266948-n7sltd1b 15 3 predispose predispose VB cord-266948-n7sltd1b 15 4 some some DT cord-266948-n7sltd1b 15 5 patients patient NNS cord-266948-n7sltd1b 15 6 to to IN cord-266948-n7sltd1b 15 7 thrombosis thrombosis NN cord-266948-n7sltd1b 15 8 , , , cord-266948-n7sltd1b 15 9 and and CC cord-266948-n7sltd1b 15 10 there there EX cord-266948-n7sltd1b 15 11 are be VBP cord-266948-n7sltd1b 15 12 instances instance NNS cord-266948-n7sltd1b 15 13 in in IN cord-266948-n7sltd1b 15 14 which which WDT cord-266948-n7sltd1b 15 15 standard standard JJ cord-266948-n7sltd1b 15 16 heparin heparin NN cord-266948-n7sltd1b 15 17 - - HYPH cord-266948-n7sltd1b 15 18 based base VBN cord-266948-n7sltd1b 15 19 anticoagulants anticoagulant NNS cord-266948-n7sltd1b 15 20 , , , cord-266948-n7sltd1b 15 21 even even RB cord-266948-n7sltd1b 15 22 at at IN cord-266948-n7sltd1b 15 23 full full JJ cord-266948-n7sltd1b 15 24 dosage dosage NN cord-266948-n7sltd1b 15 25 , , , cord-266948-n7sltd1b 15 26 are be VBP cord-266948-n7sltd1b 15 27 ineffective ineffective JJ cord-266948-n7sltd1b 15 28 in in IN cord-266948-n7sltd1b 15 29 preventing prevent VBG cord-266948-n7sltd1b 15 30 ongoing ongoing JJ cord-266948-n7sltd1b 15 31 thrombosis thrombosis NN cord-266948-n7sltd1b 15 32 . . . cord-266948-n7sltd1b 16 1 5 5 LS cord-266948-n7sltd1b 17 1 AS as IN cord-266948-n7sltd1b 17 2 patients patient NNS cord-266948-n7sltd1b 17 3 therefore therefore RB cord-266948-n7sltd1b 17 4 may may MD cord-266948-n7sltd1b 17 5 have have VB cord-266948-n7sltd1b 17 6 increased increase VBN cord-266948-n7sltd1b 17 7 risk risk NN cord-266948-n7sltd1b 17 8 for for IN cord-266948-n7sltd1b 17 9 developing develop VBG cord-266948-n7sltd1b 17 10 thromboembolic thromboembolic JJ cord-266948-n7sltd1b 17 11 complications complication NNS cord-266948-n7sltd1b 17 12 during during IN cord-266948-n7sltd1b 17 13 the the DT cord-266948-n7sltd1b 17 14 valve valve NN cord-266948-n7sltd1b 17 15 replacement replacement NN cord-266948-n7sltd1b 17 16 procedure procedure NN cord-266948-n7sltd1b 17 17 or or CC cord-266948-n7sltd1b 17 18 during during IN cord-266948-n7sltd1b 17 19 subsequent subsequent JJ cord-266948-n7sltd1b 17 20 hospitalisation hospitalisation NN cord-266948-n7sltd1b 17 21 and and CC cord-266948-n7sltd1b 17 22 recovery recovery NN cord-266948-n7sltd1b 17 23 if if IN cord-266948-n7sltd1b 17 24 they -PRON- PRP cord-266948-n7sltd1b 17 25 are be VBP cord-266948-n7sltd1b 17 26 infected infect VBN cord-266948-n7sltd1b 17 27 with with IN cord-266948-n7sltd1b 17 28 SARS SARS NNP cord-266948-n7sltd1b 17 29 - - HYPH cord-266948-n7sltd1b 17 30 CoV-2 CoV-2 NNP cord-266948-n7sltd1b 17 31 . . . cord-266948-n7sltd1b 18 1 Although although IN cord-266948-n7sltd1b 18 2 most most JJS cord-266948-n7sltd1b 18 3 patients patient NNS cord-266948-n7sltd1b 18 4 with with IN cord-266948-n7sltd1b 18 5 severe severe JJ cord-266948-n7sltd1b 18 6 COVID-19 covid-19 NN cord-266948-n7sltd1b 18 7 who who WP cord-266948-n7sltd1b 18 8 develop develop VBP cord-266948-n7sltd1b 18 9 thrombosis thrombosis NN cord-266948-n7sltd1b 18 10 develop develop VBP cord-266948-n7sltd1b 18 11 venous venous JJ cord-266948-n7sltd1b 18 12 thrombosis thrombosis NN cord-266948-n7sltd1b 18 13 , , , cord-266948-n7sltd1b 18 14 some some DT cord-266948-n7sltd1b 18 15 also also RB cord-266948-n7sltd1b 18 16 develop develop VBP cord-266948-n7sltd1b 18 17 arterial arterial JJ cord-266948-n7sltd1b 18 18 thrombosis thrombosis NN cord-266948-n7sltd1b 18 19 . . . cord-266948-n7sltd1b 19 1 In in IN cord-266948-n7sltd1b 19 2 fact fact NN cord-266948-n7sltd1b 19 3 , , , cord-266948-n7sltd1b 19 4 a a DT cord-266948-n7sltd1b 19 5 recent recent JJ cord-266948-n7sltd1b 19 6 study study NN cord-266948-n7sltd1b 19 7 showed show VBD cord-266948-n7sltd1b 19 8 that that IN cord-266948-n7sltd1b 19 9 a a DT cord-266948-n7sltd1b 19 10 prosthetic prosthetic JJ cord-266948-n7sltd1b 19 11 aortic aortic JJ cord-266948-n7sltd1b 19 12 graft graft NN cord-266948-n7sltd1b 19 13 thrombosis thrombosis NN cord-266948-n7sltd1b 19 14 patient patient NN cord-266948-n7sltd1b 19 15 died die VBD cord-266948-n7sltd1b 19 16 from from IN cord-266948-n7sltd1b 19 17 COVID-19 COVID-19 NNP cord-266948-n7sltd1b 19 18 and and CC cord-266948-n7sltd1b 19 19 that that IN cord-266948-n7sltd1b 19 20 anticoagulant anticoagulant NN cord-266948-n7sltd1b 19 21 and and CC cord-266948-n7sltd1b 19 22 thrombectomy thrombectomy NN cord-266948-n7sltd1b 19 23 procedure procedure NN cord-266948-n7sltd1b 19 24 were be VBD cord-266948-n7sltd1b 19 25 unsuccessful unsuccessful JJ cord-266948-n7sltd1b 19 26 . . . cord-266948-n7sltd1b 20 1 6 6 CD cord-266948-n7sltd1b 21 1 Therefore therefore RB cord-266948-n7sltd1b 21 2 , , , cord-266948-n7sltd1b 21 3 the the DT cord-266948-n7sltd1b 21 4 risk risk NN cord-266948-n7sltd1b 21 5 of of IN cord-266948-n7sltd1b 21 6 prosthetic prosthetic JJ cord-266948-n7sltd1b 21 7 valve valve NN cord-266948-n7sltd1b 21 8 implantation implantation NN cord-266948-n7sltd1b 21 9 should should MD cord-266948-n7sltd1b 21 10 be be VB cord-266948-n7sltd1b 21 11 seriously seriously RB cord-266948-n7sltd1b 21 12 considered consider VBN cord-266948-n7sltd1b 21 13 . . . cord-266948-n7sltd1b 22 1 If if IN cord-266948-n7sltd1b 22 2 this this DT cord-266948-n7sltd1b 22 3 pro pro JJ cord-266948-n7sltd1b 22 4 - - JJ cord-266948-n7sltd1b 22 5 cedure cedure JJ cord-266948-n7sltd1b 22 6 is be VBZ cord-266948-n7sltd1b 22 7 deemed deem VBN cord-266948-n7sltd1b 22 8 necessary necessary JJ cord-266948-n7sltd1b 22 9 , , , cord-266948-n7sltd1b 22 10 then then RB cord-266948-n7sltd1b 22 11 thrombus thrombus NN cord-266948-n7sltd1b 22 12 formation formation NN cord-266948-n7sltd1b 22 13 must must MD cord-266948-n7sltd1b 22 14 be be VB cord-266948-n7sltd1b 22 15 carefully carefully RB cord-266948-n7sltd1b 22 16 monitored monitor VBN cord-266948-n7sltd1b 22 17 . . . cord-266948-n7sltd1b 23 1 4 4 LS cord-266948-n7sltd1b 23 2 . . . cord-266948-n7sltd1b 24 1 Although although IN cord-266948-n7sltd1b 24 2 not not RB cord-266948-n7sltd1b 24 3 approved approve VBN cord-266948-n7sltd1b 24 4 for for IN cord-266948-n7sltd1b 24 5 treating treat VBG cord-266948-n7sltd1b 24 6 COVID-19 covid-19 JJ cord-266948-n7sltd1b 24 7 , , , cord-266948-n7sltd1b 24 8 antiviral antiviral JJ cord-266948-n7sltd1b 24 9 drugs drug NNS cord-266948-n7sltd1b 24 10 ( ( -LRB- cord-266948-n7sltd1b 24 11 eg eg IN cord-266948-n7sltd1b 24 12 , , , cord-266948-n7sltd1b 24 13 ritonavir ritonavir NNP cord-266948-n7sltd1b 24 14 / / SYM cord-266948-n7sltd1b 24 15 lopinavir lopinavir NNS cord-266948-n7sltd1b 24 16 ) ) -RRB- cord-266948-n7sltd1b 24 17 and and CC cord-266948-n7sltd1b 24 18 the the DT cord-266948-n7sltd1b 24 19 potential potential JJ cord-266948-n7sltd1b 24 20 antiviral antiviral JJ cord-266948-n7sltd1b 24 21 drug drug NN cord-266948-n7sltd1b 24 22 hydroxychloroquine hydroxychloroquine NNP cord-266948-n7sltd1b 24 23 are be VBP cord-266948-n7sltd1b 24 24 in in IN cord-266948-n7sltd1b 24 25 clinical clinical JJ cord-266948-n7sltd1b 24 26 trials trial NNS cord-266948-n7sltd1b 24 27 and and CC cord-266948-n7sltd1b 24 28 being be VBG cord-266948-n7sltd1b 24 29 used use VBN cord-266948-n7sltd1b 24 30 empirically empirically RB cord-266948-n7sltd1b 24 31 to to TO cord-266948-n7sltd1b 24 32 treat treat VB cord-266948-n7sltd1b 24 33 patients patient NNS cord-266948-n7sltd1b 24 34 with with IN cord-266948-n7sltd1b 24 35 COVID-19 COVID-19 NNP cord-266948-n7sltd1b 24 36 . . . cord-266948-n7sltd1b 25 1 The the DT cord-266948-n7sltd1b 25 2 use use NN cord-266948-n7sltd1b 25 3 of of IN cord-266948-n7sltd1b 25 4 ritonavir ritonavir NNS cord-266948-n7sltd1b 25 5 / / SYM cord-266948-n7sltd1b 25 6 lopinavir lopinavir NNS cord-266948-n7sltd1b 25 7 and and CC cord-266948-n7sltd1b 25 8 hydroxychloroquine hydroxychloroquine NNP cord-266948-n7sltd1b 25 9 are be VBP cord-266948-n7sltd1b 25 10 associated associate VBN cord-266948-n7sltd1b 25 11 with with IN cord-266948-n7sltd1b 25 12 cardiovascular cardiovascular JJ cord-266948-n7sltd1b 25 13 disease disease NN cord-266948-n7sltd1b 25 14 . . . cord-266948-n7sltd1b 26 1 The the DT cord-266948-n7sltd1b 26 2 antiviral antiviral JJ cord-266948-n7sltd1b 26 3 drug drug NN cord-266948-n7sltd1b 26 4 remdesivir remdesivir NNP cord-266948-n7sltd1b 26 5 has have VBZ cord-266948-n7sltd1b 26 6 shown show VBN cord-266948-n7sltd1b 26 7 some some DT cord-266948-n7sltd1b 26 8 initial initial JJ cord-266948-n7sltd1b 26 9 promise promise NN cord-266948-n7sltd1b 26 10 in in IN cord-266948-n7sltd1b 26 11 treating treat VBG cord-266948-n7sltd1b 26 12 COVID-19 covid-19 NN cord-266948-n7sltd1b 26 13 and and CC cord-266948-n7sltd1b 26 14 has have VBZ cord-266948-n7sltd1b 26 15 received receive VBN cord-266948-n7sltd1b 26 16 Emergency Emergency NNP cord-266948-n7sltd1b 26 17 Use Use NNP cord-266948-n7sltd1b 26 18 Authorization Authorization NNP cord-266948-n7sltd1b 26 19 from from IN cord-266948-n7sltd1b 26 20 the the DT cord-266948-n7sltd1b 26 21 US US NNP cord-266948-n7sltd1b 26 22 Food Food NNP cord-266948-n7sltd1b 26 23 and and CC cord-266948-n7sltd1b 26 24 Drug Drug NNP cord-266948-n7sltd1b 26 25 Agency Agency NNP cord-266948-n7sltd1b 26 26 to to TO cord-266948-n7sltd1b 26 27 treat treat VB cord-266948-n7sltd1b 26 28 patients patient NNS cord-266948-n7sltd1b 26 29 hospitalised hospitalise VBN cord-266948-n7sltd1b 26 30 with with IN cord-266948-n7sltd1b 26 31 severe severe JJ cord-266948-n7sltd1b 26 32 COVID-19 covid-19 NN cord-266948-n7sltd1b 26 33 . . . cord-266948-n7sltd1b 27 1 There there EX cord-266948-n7sltd1b 27 2 are be VBP cord-266948-n7sltd1b 27 3 no no DT cord-266948-n7sltd1b 27 4 reports report NNS cord-266948-n7sltd1b 27 5 to to IN cord-266948-n7sltd1b 27 6 date date NN cord-266948-n7sltd1b 27 7 assessing assess VBG cord-266948-n7sltd1b 27 8 the the DT cord-266948-n7sltd1b 27 9 effect effect NN cord-266948-n7sltd1b 27 10 of of IN cord-266948-n7sltd1b 27 11 remdesivir remdesivir NNP cord-266948-n7sltd1b 27 12 on on IN cord-266948-n7sltd1b 27 13 thrombosis thrombosis NN cord-266948-n7sltd1b 27 14 or or CC cord-266948-n7sltd1b 27 15 cardiovascular cardiovascular JJ cord-266948-n7sltd1b 27 16 disease disease NN cord-266948-n7sltd1b 27 17 , , , cord-266948-n7sltd1b 27 18 including include VBG cord-266948-n7sltd1b 27 19 AS as IN cord-266948-n7sltd1b 27 20 . . . cord-266948-n7sltd1b 28 1 However however RB cord-266948-n7sltd1b 28 2 , , , cord-266948-n7sltd1b 28 3 the the DT cord-266948-n7sltd1b 28 4 effects effect NNS cord-266948-n7sltd1b 28 5 of of IN cord-266948-n7sltd1b 28 6 these these DT cord-266948-n7sltd1b 28 7 drugs drug NNS cord-266948-n7sltd1b 28 8 on on IN cord-266948-n7sltd1b 28 9 valvular valvular JJ cord-266948-n7sltd1b 28 10 disease disease NN cord-266948-n7sltd1b 28 11 , , , cord-266948-n7sltd1b 28 12 thrombosis thrombosis NN cord-266948-n7sltd1b 28 13 and and CC cord-266948-n7sltd1b 28 14 other other JJ cord-266948-n7sltd1b 28 15 cardiovascular cardiovascular JJ cord-266948-n7sltd1b 28 16 disease disease NN cord-266948-n7sltd1b 28 17 can can MD cord-266948-n7sltd1b 28 18 not not RB cord-266948-n7sltd1b 28 19 be be VB cord-266948-n7sltd1b 28 20 ruled rule VBN cord-266948-n7sltd1b 28 21 out out RP cord-266948-n7sltd1b 28 22 . . . cord-266948-n7sltd1b 29 1 5 5 LS cord-266948-n7sltd1b 29 2 . . . cord-266948-n7sltd1b 30 1 Clearly clearly RB cord-266948-n7sltd1b 30 2 , , , cord-266948-n7sltd1b 30 3 patients patient NNS cord-266948-n7sltd1b 30 4 with with IN cord-266948-n7sltd1b 30 5 COVID-19 COVID-19 NNP cord-266948-n7sltd1b 30 6 are be VBP cord-266948-n7sltd1b 30 7 highly highly RB cord-266948-n7sltd1b 30 8 prothrombotic prothrombotic JJ cord-266948-n7sltd1b 30 9 with with IN cord-266948-n7sltd1b 30 10 unknown unknown JJ cord-266948-n7sltd1b 30 11 aetiology aetiology NN cord-266948-n7sltd1b 30 12 . . . cord-266948-n7sltd1b 31 1 D d NN cord-266948-n7sltd1b 31 2 - - HYPH cord-266948-n7sltd1b 31 3 dimer dimer NN cord-266948-n7sltd1b 31 4 is be VBZ cord-266948-n7sltd1b 31 5 markedly markedly RB cord-266948-n7sltd1b 31 6 elevated elevate VBN cord-266948-n7sltd1b 31 7 in in IN cord-266948-n7sltd1b 31 8 many many JJ cord-266948-n7sltd1b 31 9 patients patient NNS cord-266948-n7sltd1b 31 10 , , , cord-266948-n7sltd1b 31 11 and and CC cord-266948-n7sltd1b 31 12 meta meta NNP cord-266948-n7sltd1b 31 13 - - HYPH cord-266948-n7sltd1b 31 14 analysis analysis NNP cord-266948-n7sltd1b 31 15 revealed reveal VBD cord-266948-n7sltd1b 31 16 its -PRON- PRP$ cord-266948-n7sltd1b 31 17 association association NN cord-266948-n7sltd1b 31 18 with with IN cord-266948-n7sltd1b 31 19 disease disease NN cord-266948-n7sltd1b 31 20 severity severity NN cord-266948-n7sltd1b 31 21 and and CC cord-266948-n7sltd1b 31 22 mortality mortality NN cord-266948-n7sltd1b 31 23 . . . cord-266948-n7sltd1b 32 1 7 7 CD cord-266948-n7sltd1b 33 1 Therefore therefore RB cord-266948-n7sltd1b 33 2 , , , cord-266948-n7sltd1b 33 3 it -PRON- PRP cord-266948-n7sltd1b 33 4 is be VBZ cord-266948-n7sltd1b 33 5 critical critical JJ cord-266948-n7sltd1b 33 6 to to TO cord-266948-n7sltd1b 33 7 determine determine VB cord-266948-n7sltd1b 33 8 which which WDT cord-266948-n7sltd1b 33 9 anticoagulant anticoagulant NN cord-266948-n7sltd1b 33 10 should should MD cord-266948-n7sltd1b 33 11 be be VB cord-266948-n7sltd1b 33 12 used use VBN cord-266948-n7sltd1b 33 13 in in IN cord-266948-n7sltd1b 33 14 addition addition NN cord-266948-n7sltd1b 33 15 to to IN cord-266948-n7sltd1b 33 16 the the DT cord-266948-n7sltd1b 33 17 normal normal JJ cord-266948-n7sltd1b 33 18 prophylaxis prophylaxis NN cord-266948-n7sltd1b 33 19 regimens regimen NNS cord-266948-n7sltd1b 33 20 , , , cord-266948-n7sltd1b 33 21 since since IN cord-266948-n7sltd1b 33 22 these these DT cord-266948-n7sltd1b 33 23 are be VBP cord-266948-n7sltd1b 33 24 not not RB cord-266948-n7sltd1b 33 25 very very RB cord-266948-n7sltd1b 33 26 effective effective JJ cord-266948-n7sltd1b 33 27 in in IN cord-266948-n7sltd1b 33 28 patients patient NNS cord-266948-n7sltd1b 33 29 with with IN cord-266948-n7sltd1b 33 30 COVID-19 COVID-19 NNP cord-266948-n7sltd1b 33 31 . . . cord-266948-n7sltd1b 34 1 Recent recent JJ cord-266948-n7sltd1b 34 2 data datum NNS cord-266948-n7sltd1b 34 3 from from IN cord-266948-n7sltd1b 34 4 our -PRON- PRP$ cord-266948-n7sltd1b 34 5 group group NN cord-266948-n7sltd1b 34 6 , , , cord-266948-n7sltd1b 34 7 showed show VBD cord-266948-n7sltd1b 34 8 a a DT cord-266948-n7sltd1b 34 9 superior superior JJ cord-266948-n7sltd1b 34 10 effect effect NN cord-266948-n7sltd1b 34 11 of of IN cord-266948-n7sltd1b 34 12 the the DT cord-266948-n7sltd1b 34 13 direct direct JJ cord-266948-n7sltd1b 34 14 thrombin thrombin JJ cord-266948-n7sltd1b 34 15 inhibitor inhibitor NN cord-266948-n7sltd1b 34 16 , , , cord-266948-n7sltd1b 34 17 argatroban argatroban VBN cord-266948-n7sltd1b 34 18 in in IN cord-266948-n7sltd1b 34 19 reducing reduce VBG cord-266948-n7sltd1b 34 20 circuit circuit NN cord-266948-n7sltd1b 34 21 thrombosis thrombosis NN cord-266948-n7sltd1b 34 22 and and CC cord-266948-n7sltd1b 34 23 D d NN cord-266948-n7sltd1b 34 24 - - HYPH cord-266948-n7sltd1b 34 25 dimer dimer NN cord-266948-n7sltd1b 34 26 , , , cord-266948-n7sltd1b 34 27 whereas whereas IN cord-266948-n7sltd1b 34 28 therapeutic therapeutic JJ cord-266948-n7sltd1b 34 29 dosage dosage NN cord-266948-n7sltd1b 34 30 of of IN cord-266948-n7sltd1b 34 31 heparin heparin NN cord-266948-n7sltd1b 34 32 failed fail VBD cord-266948-n7sltd1b 34 33 to to TO cord-266948-n7sltd1b 34 34 prevent prevent VB cord-266948-n7sltd1b 34 35 thrombosis thrombosis NN cord-266948-n7sltd1b 34 36 . . . cord-266948-n7sltd1b 35 1 5 5 LS cord-266948-n7sltd1b 36 1 Therefore therefore RB cord-266948-n7sltd1b 36 2 , , , cord-266948-n7sltd1b 36 3 direct direct JJ cord-266948-n7sltd1b 36 4 thrombin thrombin NN cord-266948-n7sltd1b 36 5 inhibitors inhibitor NNS cord-266948-n7sltd1b 36 6 should should MD cord-266948-n7sltd1b 36 7 be be VB cord-266948-n7sltd1b 36 8 considered consider VBN cord-266948-n7sltd1b 36 9 for for IN cord-266948-n7sltd1b 36 10 AS as IN cord-266948-n7sltd1b 36 11 patients patient NNS cord-266948-n7sltd1b 36 12 who who WP cord-266948-n7sltd1b 36 13 test test VBP cord-266948-n7sltd1b 36 14 positive positive JJ cord-266948-n7sltd1b 36 15 for for IN cord-266948-n7sltd1b 36 16 SARS SARS NNP cord-266948-n7sltd1b 36 17 - - HYPH cord-266948-n7sltd1b 36 18 CoV-2 CoV-2 NNP cord-266948-n7sltd1b 36 19 , , , cord-266948-n7sltd1b 36 20 since since IN cord-266948-n7sltd1b 36 21 both both DT cord-266948-n7sltd1b 36 22 COVID-19 covid-19 VBP cord-266948-n7sltd1b 36 23 and and CC cord-266948-n7sltd1b 36 24 AS as IN cord-266948-n7sltd1b 36 25 procedure procedure NN cord-266948-n7sltd1b 36 26 can can MD cord-266948-n7sltd1b 36 27 increase increase VB cord-266948-n7sltd1b 36 28 the the DT cord-266948-n7sltd1b 36 29 risk risk NN cord-266948-n7sltd1b 36 30 of of IN cord-266948-n7sltd1b 36 31 thrombosis thrombosis NN cord-266948-n7sltd1b 36 32 . . . cord-266948-n7sltd1b 37 1 6 6 LS cord-266948-n7sltd1b 37 2 . . . cord-266948-n7sltd1b 38 1 If if IN cord-266948-n7sltd1b 38 2 AS as IN cord-266948-n7sltd1b 38 3 patients patient NNS cord-266948-n7sltd1b 38 4 have have VBP cord-266948-n7sltd1b 38 5 COVID-19 covid-19 CD cord-266948-n7sltd1b 38 6 and and CC cord-266948-n7sltd1b 38 7 shortness shortness NN cord-266948-n7sltd1b 38 8 of of IN cord-266948-n7sltd1b 38 9 breath breath NN cord-266948-n7sltd1b 38 10 , , , cord-266948-n7sltd1b 38 11 the the DT cord-266948-n7sltd1b 38 12 risk risk NN cord-266948-n7sltd1b 38 13 of of IN cord-266948-n7sltd1b 38 14 morbidities morbidity NNS cord-266948-n7sltd1b 38 15 is be VBZ cord-266948-n7sltd1b 38 16 increased increase VBN cord-266948-n7sltd1b 38 17 , , , cord-266948-n7sltd1b 38 18 as as IN cord-266948-n7sltd1b 38 19 shortness shortness NN cord-266948-n7sltd1b 38 20 of of IN cord-266948-n7sltd1b 38 21 breath breath NN cord-266948-n7sltd1b 38 22 can can MD cord-266948-n7sltd1b 38 23 be be VB cord-266948-n7sltd1b 38 24 caused cause VBN cord-266948-n7sltd1b 38 25 by by IN cord-266948-n7sltd1b 38 26 either either DT cord-266948-n7sltd1b 38 27 COVID-19 COVID-19 NNP cord-266948-n7sltd1b 38 28 or or CC cord-266948-n7sltd1b 38 29 AS AS NNP cord-266948-n7sltd1b 38 30 . . . cord-266948-n7sltd1b 39 1 Under under IN cord-266948-n7sltd1b 39 2 such such JJ cord-266948-n7sltd1b 39 3 circumstance circumstance NN cord-266948-n7sltd1b 39 4 , , , cord-266948-n7sltd1b 39 5 echocardiography echocardiography NN cord-266948-n7sltd1b 39 6 is be VBZ cord-266948-n7sltd1b 39 7 important important JJ cord-266948-n7sltd1b 39 8 for for IN cord-266948-n7sltd1b 39 9 accurate accurate JJ cord-266948-n7sltd1b 39 10 diagnosis diagnosis NN cord-266948-n7sltd1b 39 11 of of IN cord-266948-n7sltd1b 39 12 the the DT cord-266948-n7sltd1b 39 13 status status NN cord-266948-n7sltd1b 39 14 of of IN cord-266948-n7sltd1b 39 15 the the DT cord-266948-n7sltd1b 39 16 patient patient NN cord-266948-n7sltd1b 39 17 's 's POS cord-266948-n7sltd1b 39 18 AS AS NNP cord-266948-n7sltd1b 39 19 . . . cord-266948-n7sltd1b 40 1 If if IN cord-266948-n7sltd1b 40 2 the the DT cord-266948-n7sltd1b 40 3 shortness shortness NN cord-266948-n7sltd1b 40 4 of of IN cord-266948-n7sltd1b 40 5 breath breath NN cord-266948-n7sltd1b 40 6 is be VBZ cord-266948-n7sltd1b 40 7 not not RB cord-266948-n7sltd1b 40 8 caused cause VBN cord-266948-n7sltd1b 40 9 by by IN cord-266948-n7sltd1b 40 10 AS AS NNP cord-266948-n7sltd1b 40 11 , , , cord-266948-n7sltd1b 40 12 markers marker NNS cord-266948-n7sltd1b 40 13 for for IN cord-266948-n7sltd1b 40 14 COVID-19 covid-19 CD cord-266948-n7sltd1b 40 15 , , , cord-266948-n7sltd1b 40 16 such such JJ cord-266948-n7sltd1b 40 17 as as IN cord-266948-n7sltd1b 40 18 interleukin-6 interleukin-6 NNP cord-266948-n7sltd1b 40 19 , , , cord-266948-n7sltd1b 40 20 D d NN cord-266948-n7sltd1b 40 21 - - HYPH cord-266948-n7sltd1b 40 22 dimer dimer NN cord-266948-n7sltd1b 40 23 and and CC cord-266948-n7sltd1b 40 24 complement complement VB cord-266948-n7sltd1b 40 25 proteins protein NNS cord-266948-n7sltd1b 40 26 and and CC cord-266948-n7sltd1b 40 27 white white JJ cord-266948-n7sltd1b 40 28 cell cell NN cord-266948-n7sltd1b 40 29 counts count NNS cord-266948-n7sltd1b 40 30 , , , cord-266948-n7sltd1b 40 31 and and CC cord-266948-n7sltd1b 40 32 acute acute JJ cord-266948-n7sltd1b 40 33 white white JJ cord-266948-n7sltd1b 40 34 cell cell NN cord-266948-n7sltd1b 40 35 counts count NNS cord-266948-n7sltd1b 40 36 should should MD cord-266948-n7sltd1b 40 37 be be VB cord-266948-n7sltd1b 40 38 examined examine VBN cord-266948-n7sltd1b 40 39 , , , cord-266948-n7sltd1b 40 40 as as IN cord-266948-n7sltd1b 40 41 these these DT cord-266948-n7sltd1b 40 42 levels level NNS cord-266948-n7sltd1b 40 43 should should MD cord-266948-n7sltd1b 40 44 not not RB cord-266948-n7sltd1b 40 45 rise rise VB cord-266948-n7sltd1b 40 46 in in IN cord-266948-n7sltd1b 40 47 stable stable JJ cord-266948-n7sltd1b 40 48 AS as IN cord-266948-n7sltd1b 40 49 patients patient NNS cord-266948-n7sltd1b 40 50 . . . cord-266948-n7sltd1b 41 1 If if IN cord-266948-n7sltd1b 41 2 , , , cord-266948-n7sltd1b 41 3 however however RB cord-266948-n7sltd1b 41 4 , , , cord-266948-n7sltd1b 41 5 the the DT cord-266948-n7sltd1b 41 6 respiratory respiratory JJ cord-266948-n7sltd1b 41 7 symptom symptom NN cord-266948-n7sltd1b 41 8 is be VBZ cord-266948-n7sltd1b 41 9 the the DT cord-266948-n7sltd1b 41 10 result result NN cord-266948-n7sltd1b 41 11 of of IN cord-266948-n7sltd1b 41 12 AS AS NNP cord-266948-n7sltd1b 41 13 , , , cord-266948-n7sltd1b 41 14 which which WDT cord-266948-n7sltd1b 41 15 can can MD cord-266948-n7sltd1b 41 16 be be VB cord-266948-n7sltd1b 41 17 fatal fatal JJ cord-266948-n7sltd1b 41 18 in in IN cord-266948-n7sltd1b 41 19 itself -PRON- PRP cord-266948-n7sltd1b 41 20 , , , cord-266948-n7sltd1b 41 21 TAVR TAVR NNP cord-266948-n7sltd1b 41 22 may may MD cord-266948-n7sltd1b 41 23 be be VB cord-266948-n7sltd1b 41 24 a a DT cord-266948-n7sltd1b 41 25 better well JJR cord-266948-n7sltd1b 41 26 option option NN cord-266948-n7sltd1b 41 27 than than IN cord-266948-n7sltd1b 41 28 AVR AVR NNP cord-266948-n7sltd1b 41 29 considering consider VBG cord-266948-n7sltd1b 41 30 the the DT cord-266948-n7sltd1b 41 31 very very RB cord-266948-n7sltd1b 41 32 high high JJ cord-266948-n7sltd1b 41 33 - - HYPH cord-266948-n7sltd1b 41 34 risk risk NN cord-266948-n7sltd1b 41 35 status status NN cord-266948-n7sltd1b 41 36 of of IN cord-266948-n7sltd1b 41 37 patients patient NNS cord-266948-n7sltd1b 41 38 with with IN cord-266948-n7sltd1b 41 39 COVID-19 covid-19 JJ cord-266948-n7sltd1b 41 40 comorbidities comorbiditie NNS cord-266948-n7sltd1b 41 41 . . . cord-266948-n7sltd1b 42 1 Concurrent concurrent JJ cord-266948-n7sltd1b 42 2 monitoring monitoring NN cord-266948-n7sltd1b 42 3 of of IN cord-266948-n7sltd1b 42 4 the the DT cord-266948-n7sltd1b 42 5 status status NN cord-266948-n7sltd1b 42 6 of of IN cord-266948-n7sltd1b 42 7 AS as IN cord-266948-n7sltd1b 42 8 by by IN cord-266948-n7sltd1b 42 9 echocardiography echocardiography NN cord-266948-n7sltd1b 42 10 will will MD cord-266948-n7sltd1b 42 11 avoid avoid VB cord-266948-n7sltd1b 42 12 the the DT cord-266948-n7sltd1b 42 13 complicating complicate VBG cord-266948-n7sltd1b 42 14 comorbidity comorbidity NN cord-266948-n7sltd1b 42 15 of of IN cord-266948-n7sltd1b 42 16 thrombosis thrombosis NN cord-266948-n7sltd1b 42 17 , , , cord-266948-n7sltd1b 42 18 for for IN cord-266948-n7sltd1b 42 19 which which WDT cord-266948-n7sltd1b 42 20 there there EX cord-266948-n7sltd1b 42 21 are be VBP cord-266948-n7sltd1b 42 22 currently currently RB cord-266948-n7sltd1b 42 23 no no DT cord-266948-n7sltd1b 42 24 clear clear JJ cord-266948-n7sltd1b 42 25 treatment treatment NN cord-266948-n7sltd1b 42 26 guidelines guideline NNS cord-266948-n7sltd1b 42 27 for for IN cord-266948-n7sltd1b 42 28 patients patient NNS cord-266948-n7sltd1b 42 29 with with IN cord-266948-n7sltd1b 42 30 COVID-19 COVID-19 NNP cord-266948-n7sltd1b 42 31 . . NNP cord-266948-n7sltd1b 42 32 7 7 CD cord-266948-n7sltd1b 42 33 . . . cord-266948-n7sltd1b 43 1 SARS SARS NNP cord-266948-n7sltd1b 43 2 - - HYPH cord-266948-n7sltd1b 43 3 CoV-2 CoV-2 NNP cord-266948-n7sltd1b 43 4 enters enter VBZ cord-266948-n7sltd1b 43 5 human human JJ cord-266948-n7sltd1b 43 6 cells cell NNS cord-266948-n7sltd1b 43 7 by by IN cord-266948-n7sltd1b 43 8 binding bind VBG cord-266948-n7sltd1b 43 9 of of IN cord-266948-n7sltd1b 43 10 the the DT cord-266948-n7sltd1b 43 11 viral viral JJ cord-266948-n7sltd1b 43 12 spike spike NN cord-266948-n7sltd1b 43 13 protein protein NN cord-266948-n7sltd1b 43 14 to to IN cord-266948-n7sltd1b 43 15 the the DT cord-266948-n7sltd1b 43 16 membrane membrane NN cord-266948-n7sltd1b 43 17 - - HYPH cord-266948-n7sltd1b 43 18 bound bind VBN cord-266948-n7sltd1b 43 19 form form NN cord-266948-n7sltd1b 43 20 of of IN cord-266948-n7sltd1b 43 21 the the DT cord-266948-n7sltd1b 43 22 aminopeptidase aminopeptidase NN cord-266948-n7sltd1b 43 23 ACE2 ACE2 NNP cord-266948-n7sltd1b 43 24 on on IN cord-266948-n7sltd1b 43 25 cells cell NNS cord-266948-n7sltd1b 43 26 . . . cord-266948-n7sltd1b 44 1 ACE2 ACE2 NNP cord-266948-n7sltd1b 44 2 plays play VBZ cord-266948-n7sltd1b 44 3 an an DT cord-266948-n7sltd1b 44 4 important important JJ cord-266948-n7sltd1b 44 5 regulatory regulatory JJ cord-266948-n7sltd1b 44 6 role role NN cord-266948-n7sltd1b 44 7 in in IN cord-266948-n7sltd1b 44 8 the the DT cord-266948-n7sltd1b 44 9 renin renin NN cord-266948-n7sltd1b 44 10 - - HYPH cord-266948-n7sltd1b 44 11 angiotensin angiotensin NN cord-266948-n7sltd1b 44 12 system system NN cord-266948-n7sltd1b 44 13 , , , cord-266948-n7sltd1b 44 14 which which WDT cord-266948-n7sltd1b 44 15 regulates regulate VBZ cord-266948-n7sltd1b 44 16 normal normal JJ cord-266948-n7sltd1b 44 17 and and CC cord-266948-n7sltd1b 44 18 pathological pathological JJ cord-266948-n7sltd1b 44 19 vascular vascular JJ cord-266948-n7sltd1b 44 20 tone tone NN cord-266948-n7sltd1b 44 21 and and CC cord-266948-n7sltd1b 44 22 blood blood NN cord-266948-n7sltd1b 44 23 pressure pressure NN cord-266948-n7sltd1b 44 24 . . . cord-266948-n7sltd1b 45 1 Various various JJ cord-266948-n7sltd1b 45 2 types type NNS cord-266948-n7sltd1b 45 3 of of IN cord-266948-n7sltd1b 45 4 medications medication NNS cord-266948-n7sltd1b 45 5 that that WDT cord-266948-n7sltd1b 45 6 inhibit inhibit VBP cord-266948-n7sltd1b 45 7 this this DT cord-266948-n7sltd1b 45 8 system system NN cord-266948-n7sltd1b 45 9 are be VBP cord-266948-n7sltd1b 45 10 used use VBN cord-266948-n7sltd1b 45 11 to to TO cord-266948-n7sltd1b 45 12 treat treat VB cord-266948-n7sltd1b 45 13 patients patient NNS cord-266948-n7sltd1b 45 14 suffering suffer VBG cord-266948-n7sltd1b 45 15 from from IN cord-266948-n7sltd1b 45 16 cardiovascular cardiovascular JJ cord-266948-n7sltd1b 45 17 disease disease NN cord-266948-n7sltd1b 45 18 , , , cord-266948-n7sltd1b 45 19 including include VBG cord-266948-n7sltd1b 45 20 those those DT cord-266948-n7sltd1b 45 21 with with IN cord-266948-n7sltd1b 45 22 AS AS NNP cord-266948-n7sltd1b 45 23 , , , cord-266948-n7sltd1b 45 24 although although IN cord-266948-n7sltd1b 45 25 none none NN cord-266948-n7sltd1b 45 26 successful successful JJ cord-266948-n7sltd1b 45 27 in in IN cord-266948-n7sltd1b 45 28 clinical clinical JJ cord-266948-n7sltd1b 45 29 trial trial NN cord-266948-n7sltd1b 45 30 for for IN cord-266948-n7sltd1b 45 31 AS AS NNP cord-266948-n7sltd1b 45 32 . . . cord-266948-n7sltd1b 46 1 Studies study NNS cord-266948-n7sltd1b 46 2 in in IN cord-266948-n7sltd1b 46 3 animals animal NNS cord-266948-n7sltd1b 46 4 have have VBP cord-266948-n7sltd1b 46 5 suggested suggest VBN cord-266948-n7sltd1b 46 6 that that IN cord-266948-n7sltd1b 46 7 inhibitors inhibitor NNS cord-266948-n7sltd1b 46 8 of of IN cord-266948-n7sltd1b 46 9 this this DT cord-266948-n7sltd1b 46 10 system system NN cord-266948-n7sltd1b 46 11 can can MD cord-266948-n7sltd1b 46 12 upregulate upregulate VB cord-266948-n7sltd1b 46 13 ACE2 ACE2 NNP cord-266948-n7sltd1b 46 14 expression expression NN cord-266948-n7sltd1b 46 15 , , , cord-266948-n7sltd1b 46 16 which which WDT cord-266948-n7sltd1b 46 17 led lead VBD cord-266948-n7sltd1b 46 18 some some DT cord-266948-n7sltd1b 46 19 investigators investigator NNS cord-266948-n7sltd1b 46 20 to to TO cord-266948-n7sltd1b 46 21 postulate postulate VB cord-266948-n7sltd1b 46 22 that that IN cord-266948-n7sltd1b 46 23 patients patient NNS cord-266948-n7sltd1b 46 24 receiving receive VBG cord-266948-n7sltd1b 46 25 those those DT cord-266948-n7sltd1b 46 26 inhibitors inhibitor NNS cord-266948-n7sltd1b 46 27 may may MD cord-266948-n7sltd1b 46 28 be be VB cord-266948-n7sltd1b 46 29 at at IN cord-266948-n7sltd1b 46 30 high high JJ cord-266948-n7sltd1b 46 31 risk risk NN cord-266948-n7sltd1b 46 32 of of IN cord-266948-n7sltd1b 46 33 contracting contract VBG cord-266948-n7sltd1b 46 34 a a DT cord-266948-n7sltd1b 46 35 SARS SARS NNP cord-266948-n7sltd1b 46 36 - - HYPH cord-266948-n7sltd1b 46 37 CoV-2 CoV-2 NNP cord-266948-n7sltd1b 46 38 infection infection NN cord-266948-n7sltd1b 46 39 , , , cord-266948-n7sltd1b 46 40 which which WDT cord-266948-n7sltd1b 46 41 needs need VBZ cord-266948-n7sltd1b 46 42 to to TO cord-266948-n7sltd1b 46 43 be be VB cord-266948-n7sltd1b 46 44 validated validate VBN cord-266948-n7sltd1b 46 45 experimentally experimentally RB cord-266948-n7sltd1b 46 46 . . . cord-266948-n7sltd1b 47 1 8 8 CD cord-266948-n7sltd1b 48 1 Therefore therefore RB cord-266948-n7sltd1b 48 2 , , , cord-266948-n7sltd1b 48 3 it -PRON- PRP cord-266948-n7sltd1b 48 4 is be VBZ cord-266948-n7sltd1b 48 5 critical critical JJ cord-266948-n7sltd1b 48 6 to to TO cord-266948-n7sltd1b 48 7 carefully carefully RB cord-266948-n7sltd1b 48 8 assess assess VB cord-266948-n7sltd1b 48 9 and and CC cord-266948-n7sltd1b 48 10 differentiate differentiate VB cord-266948-n7sltd1b 48 11 symptoms symptom NNS cord-266948-n7sltd1b 48 12 in in IN cord-266948-n7sltd1b 48 13 acute acute JJ cord-266948-n7sltd1b 48 14 AS as IN cord-266948-n7sltd1b 48 15 versus versus IN cord-266948-n7sltd1b 48 16 COVID-19 covid-19 CD cord-266948-n7sltd1b 48 17 cases case NNS cord-266948-n7sltd1b 48 18 wherein wherein VBZ cord-266948-n7sltd1b 48 19 comorbidities comorbiditie NNS cord-266948-n7sltd1b 48 20 and and CC cord-266948-n7sltd1b 48 21 risk risk NN cord-266948-n7sltd1b 48 22 always always RB cord-266948-n7sltd1b 48 23 rise rise VBP cord-266948-n7sltd1b 48 24 . . . cord-266948-n7sltd1b 49 1 If if IN cord-266948-n7sltd1b 49 2 the the DT cord-266948-n7sltd1b 49 3 AS AS NNP cord-266948-n7sltd1b 49 4 patient patient NN cord-266948-n7sltd1b 49 5 can can MD cord-266948-n7sltd1b 49 6 not not RB cord-266948-n7sltd1b 49 7 delay delay VB cord-266948-n7sltd1b 49 8 life life NN cord-266948-n7sltd1b 49 9 - - HYPH cord-266948-n7sltd1b 49 10 saving save VBG cord-266948-n7sltd1b 49 11 procedures procedure NNS cord-266948-n7sltd1b 49 12 and and CC cord-266948-n7sltd1b 49 13 are be VBP cord-266948-n7sltd1b 49 14 taking take VBG cord-266948-n7sltd1b 49 15 the the DT cord-266948-n7sltd1b 49 16 ACE ACE NNP cord-266948-n7sltd1b 49 17 inhibitors inhibitor NNS cord-266948-n7sltd1b 49 18 , , , cord-266948-n7sltd1b 49 19 which which WDT cord-266948-n7sltd1b 49 20 can can MD cord-266948-n7sltd1b 49 21 be be VB cord-266948-n7sltd1b 49 22 discontinued discontinue VBN cord-266948-n7sltd1b 49 23 but but CC cord-266948-n7sltd1b 49 24 , , , cord-266948-n7sltd1b 49 25 as as IN cord-266948-n7sltd1b 49 26 discussed discuss VBN cord-266948-n7sltd1b 49 27 above above RB cord-266948-n7sltd1b 49 28 , , , cord-266948-n7sltd1b 49 29 other other JJ cord-266948-n7sltd1b 49 30 challenges challenge NNS cord-266948-n7sltd1b 49 31 , , , cord-266948-n7sltd1b 49 32 such such JJ cord-266948-n7sltd1b 49 33 as as IN cord-266948-n7sltd1b 49 34 management management NN cord-266948-n7sltd1b 49 35 of of IN cord-266948-n7sltd1b 49 36 thrombosis thrombosis NN cord-266948-n7sltd1b 49 37 , , , cord-266948-n7sltd1b 49 38 also also RB cord-266948-n7sltd1b 49 39 need need VBP cord-266948-n7sltd1b 49 40 careful careful JJ cord-266948-n7sltd1b 49 41 consideration consideration NN cord-266948-n7sltd1b 49 42 . . . cord-266948-n7sltd1b 50 1 The the DT cord-266948-n7sltd1b 50 2 disease disease NN cord-266948-n7sltd1b 50 3 - - HYPH cord-266948-n7sltd1b 50 4 causing cause VBG cord-266948-n7sltd1b 50 5 mechanisms mechanism NNS cord-266948-n7sltd1b 50 6 of of IN cord-266948-n7sltd1b 50 7 both both DT cord-266948-n7sltd1b 50 8 AS AS NNP cord-266948-n7sltd1b 50 9 and and CC cord-266948-n7sltd1b 50 10 COVID-19 COVID-19 NNP cord-266948-n7sltd1b 50 11 are be VBP cord-266948-n7sltd1b 50 12 not not RB cord-266948-n7sltd1b 50 13 well well RB cord-266948-n7sltd1b 50 14 known known JJ cord-266948-n7sltd1b 50 15 . . . cord-266948-n7sltd1b 51 1 Both both DT cord-266948-n7sltd1b 51 2 are be VBP cord-266948-n7sltd1b 51 3 associated associate VBN cord-266948-n7sltd1b 51 4 with with IN cord-266948-n7sltd1b 51 5 high high JJ cord-266948-n7sltd1b 51 6 - - HYPH cord-266948-n7sltd1b 51 7 risk risk NN cord-266948-n7sltd1b 51 8 underlying underlying JJ cord-266948-n7sltd1b 51 9 conditions condition NNS cord-266948-n7sltd1b 51 10 , , , cord-266948-n7sltd1b 51 11 including include VBG cord-266948-n7sltd1b 51 12 age age NN cord-266948-n7sltd1b 51 13 , , , cord-266948-n7sltd1b 51 14 obesity obesity NN cord-266948-n7sltd1b 51 15 , , , cord-266948-n7sltd1b 51 16 diabetes diabetes NN cord-266948-n7sltd1b 51 17 , , , cord-266948-n7sltd1b 51 18 hypertension hypertension NN cord-266948-n7sltd1b 51 19 and and CC cord-266948-n7sltd1b 51 20 male male JJ cord-266948-n7sltd1b 51 21 gender gender NN cord-266948-n7sltd1b 51 22 , , , cord-266948-n7sltd1b 51 23 which which WDT cord-266948-n7sltd1b 51 24 increases increase VBZ cord-266948-n7sltd1b 51 25 the the DT cord-266948-n7sltd1b 51 26 complexity complexity NN cord-266948-n7sltd1b 51 27 of of IN cord-266948-n7sltd1b 51 28 comorbidities comorbiditie NNS cord-266948-n7sltd1b 51 29 and and CC cord-266948-n7sltd1b 51 30 decision decision NN cord-266948-n7sltd1b 51 31 making making NN cord-266948-n7sltd1b 51 32 , , , cord-266948-n7sltd1b 51 33 especially especially RB cord-266948-n7sltd1b 51 34 in in IN cord-266948-n7sltd1b 51 35 the the DT cord-266948-n7sltd1b 51 36 ICU ICU NNP cord-266948-n7sltd1b 51 37 setting set VBG cord-266948-n7sltd1b 51 38 when when WRB cord-266948-n7sltd1b 51 39 patients patient NNS cord-266948-n7sltd1b 51 40 are be VBP cord-266948-n7sltd1b 51 41 on on IN cord-266948-n7sltd1b 51 42 ventilators ventilator NNS cord-266948-n7sltd1b 51 43 and and CC cord-266948-n7sltd1b 51 44 oral oral JJ cord-266948-n7sltd1b 51 45 treatments treatment NNS cord-266948-n7sltd1b 51 46 are be VBP cord-266948-n7sltd1b 51 47 not not RB cord-266948-n7sltd1b 51 48 an an DT cord-266948-n7sltd1b 51 49 option option NN cord-266948-n7sltd1b 51 50 . . . cord-266948-n7sltd1b 52 1 Thus thus RB cord-266948-n7sltd1b 52 2 , , , cord-266948-n7sltd1b 52 3 understanding understand VBG cord-266948-n7sltd1b 52 4 the the DT cord-266948-n7sltd1b 52 5 mechanisms mechanism NNS cord-266948-n7sltd1b 52 6 of of IN cord-266948-n7sltd1b 52 7 these these DT cord-266948-n7sltd1b 52 8 two two CD cord-266948-n7sltd1b 52 9 diseases disease NNS cord-266948-n7sltd1b 52 10 is be VBZ cord-266948-n7sltd1b 52 11 required require VBN cord-266948-n7sltd1b 52 12 to to TO cord-266948-n7sltd1b 52 13 improve improve VB cord-266948-n7sltd1b 52 14 treatments treatment NNS cord-266948-n7sltd1b 52 15 of of IN cord-266948-n7sltd1b 52 16 these these DT cord-266948-n7sltd1b 52 17 diseases disease NNS cord-266948-n7sltd1b 52 18 separately separately RB cord-266948-n7sltd1b 52 19 as as RB cord-266948-n7sltd1b 52 20 well well RB cord-266948-n7sltd1b 52 21 as as IN cord-266948-n7sltd1b 52 22 when when WRB cord-266948-n7sltd1b 52 23 they -PRON- PRP cord-266948-n7sltd1b 52 24 occur occur VBP cord-266948-n7sltd1b 52 25 together together RB cord-266948-n7sltd1b 52 26 . . . cord-266948-n7sltd1b 53 1 Because because IN cord-266948-n7sltd1b 53 2 it -PRON- PRP cord-266948-n7sltd1b 53 3 is be VBZ cord-266948-n7sltd1b 53 4 almost almost RB cord-266948-n7sltd1b 53 5 impossible impossible JJ cord-266948-n7sltd1b 53 6 to to TO cord-266948-n7sltd1b 53 7 test test VB cord-266948-n7sltd1b 53 8 the the DT cord-266948-n7sltd1b 53 9 mechanism mechanism NN cord-266948-n7sltd1b 53 10 of of IN cord-266948-n7sltd1b 53 11 AS AS NNP cord-266948-n7sltd1b 53 12 or or CC cord-266948-n7sltd1b 53 13 COVID-19 covid-19 VB cord-266948-n7sltd1b 53 14 in in IN cord-266948-n7sltd1b 53 15 humans human NNS cord-266948-n7sltd1b 53 16 , , , cord-266948-n7sltd1b 53 17 other other JJ cord-266948-n7sltd1b 53 18 than than IN cord-266948-n7sltd1b 53 19 correlative correlative JJ cord-266948-n7sltd1b 53 20 studies study NNS cord-266948-n7sltd1b 53 21 , , , cord-266948-n7sltd1b 53 22 animal animal NN cord-266948-n7sltd1b 53 23 studies study NNS cord-266948-n7sltd1b 53 24 are be VBP cord-266948-n7sltd1b 53 25 needed need VBN cord-266948-n7sltd1b 53 26 . . . cord-266948-n7sltd1b 54 1 We -PRON- PRP cord-266948-n7sltd1b 54 2 have have VBP cord-266948-n7sltd1b 54 3 established establish VBN cord-266948-n7sltd1b 54 4 a a DT cord-266948-n7sltd1b 54 5 new new JJ cord-266948-n7sltd1b 54 6 robust robust JJ cord-266948-n7sltd1b 54 7 mouse mouse NN cord-266948-n7sltd1b 54 8 model model NN cord-266948-n7sltd1b 54 9 of of IN cord-266948-n7sltd1b 54 10 AS as IN cord-266948-n7sltd1b 54 11 that that WDT cord-266948-n7sltd1b 54 12 simulates simulate VBZ cord-266948-n7sltd1b 54 13 AS as IN cord-266948-n7sltd1b 54 14 in in IN cord-266948-n7sltd1b 54 15 human human NN cord-266948-n7sltd1b 54 16 and and CC cord-266948-n7sltd1b 54 17 identified identify VBD cord-266948-n7sltd1b 54 18 platelet platelet NN cord-266948-n7sltd1b 54 19 transforming transform VBG cord-266948-n7sltd1b 54 20 growth growth NN cord-266948-n7sltd1b 54 21 factor factor NN cord-266948-n7sltd1b 54 22 beta-1 beta-1 JJ cord-266948-n7sltd1b 54 23 as as IN cord-266948-n7sltd1b 54 24 a a DT cord-266948-n7sltd1b 54 25 major major JJ cord-266948-n7sltd1b 54 26 driver driver NN cord-266948-n7sltd1b 54 27 of of IN cord-266948-n7sltd1b 54 28 AS as JJ cord-266948-n7sltd1b 54 29 progression progression NN cord-266948-n7sltd1b 54 30 . . . cord-266948-n7sltd1b 55 1 9 9 CD cord-266948-n7sltd1b 56 1 The the DT cord-266948-n7sltd1b 56 2 new new JJ cord-266948-n7sltd1b 56 3 SARS SARS NNP cord-266948-n7sltd1b 56 4 - - HYPH cord-266948-n7sltd1b 56 5 CoV-2 CoV-2 NNP cord-266948-n7sltd1b 56 6 animal animal NN cord-266948-n7sltd1b 56 7 models model NNS cord-266948-n7sltd1b 56 8 10 10 CD cord-266948-n7sltd1b 56 9 can can MD cord-266948-n7sltd1b 56 10 be be VB cord-266948-n7sltd1b 56 11 adapted adapt VBN cord-266948-n7sltd1b 56 12 to to IN cord-266948-n7sltd1b 56 13 comorbid comorbid VB cord-266948-n7sltd1b 56 14 disease disease NN cord-266948-n7sltd1b 56 15 models model NNS cord-266948-n7sltd1b 56 16 , , , cord-266948-n7sltd1b 56 17 such such JJ cord-266948-n7sltd1b 56 18 as as IN cord-266948-n7sltd1b 56 19 AS AS NNP cord-266948-n7sltd1b 56 20 , , , cord-266948-n7sltd1b 56 21 to to TO cord-266948-n7sltd1b 56 22 facilitate facilitate VB cord-266948-n7sltd1b 56 23 the the DT cord-266948-n7sltd1b 56 24 identification identification NN cord-266948-n7sltd1b 56 25 of of IN cord-266948-n7sltd1b 56 26 underlying underlie VBG cord-266948-n7sltd1b 56 27 mechanisms mechanism NNS cord-266948-n7sltd1b 56 28 . . . cord-266948-n7sltd1b 57 1 These these DT cord-266948-n7sltd1b 57 2 models model NNS cord-266948-n7sltd1b 57 3 will will MD cord-266948-n7sltd1b 57 4 potentially potentially RB cord-266948-n7sltd1b 57 5 inform inform VB cord-266948-n7sltd1b 57 6 the the DT cord-266948-n7sltd1b 57 7 development development NN cord-266948-n7sltd1b 57 8 of of IN cord-266948-n7sltd1b 57 9 therapies therapy NNS cord-266948-n7sltd1b 57 10 for for IN cord-266948-n7sltd1b 57 11 AS AS NNP cord-266948-n7sltd1b 57 12 and and CC cord-266948-n7sltd1b 57 13 COVID-19 COVID-19 NNP cord-266948-n7sltd1b 57 14 . . . cord-266948-n7sltd1b 58 1 Finally finally RB cord-266948-n7sltd1b 58 2 , , , cord-266948-n7sltd1b 58 3 COVID-19 COVID-19 NNP cord-266948-n7sltd1b 58 4 may may MD cord-266948-n7sltd1b 58 5 pose pose VB cord-266948-n7sltd1b 58 6 an an DT cord-266948-n7sltd1b 58 7 additional additional JJ cord-266948-n7sltd1b 58 8 risk risk NN cord-266948-n7sltd1b 58 9 for for IN cord-266948-n7sltd1b 58 10 other other JJ cord-266948-n7sltd1b 58 11 life life NN cord-266948-n7sltd1b 58 12 - - HYPH cord-266948-n7sltd1b 58 13 saving save VBG cord-266948-n7sltd1b 58 14 procedures procedure NNS cord-266948-n7sltd1b 58 15 where where WRB cord-266948-n7sltd1b 58 16 thromboembolic thromboembolic JJ cord-266948-n7sltd1b 58 17 events event NNS cord-266948-n7sltd1b 58 18 are be VBP cord-266948-n7sltd1b 58 19 common common JJ cord-266948-n7sltd1b 58 20 , , , cord-266948-n7sltd1b 58 21 such such JJ cord-266948-n7sltd1b 58 22 as as IN cord-266948-n7sltd1b 58 23 cardiac cardiac JJ cord-266948-n7sltd1b 58 24 catheterization catheterization NN cord-266948-n7sltd1b 58 25 , , , cord-266948-n7sltd1b 58 26 implantation implantation NN cord-266948-n7sltd1b 58 27 of of IN cord-266948-n7sltd1b 58 28 permanent permanent JJ cord-266948-n7sltd1b 58 29 pacemaker pacemaker NN cord-266948-n7sltd1b 58 30 and and CC cord-266948-n7sltd1b 58 31 left leave VBN cord-266948-n7sltd1b 58 32 ventricular ventricular JJ cord-266948-n7sltd1b 58 33 assist assist VB cord-266948-n7sltd1b 58 34 device device NN cord-266948-n7sltd1b 58 35 in in IN cord-266948-n7sltd1b 58 36 heart heart NN cord-266948-n7sltd1b 58 37 failure failure NN cord-266948-n7sltd1b 58 38 patients patient NNS cord-266948-n7sltd1b 58 39 or or CC cord-266948-n7sltd1b 58 40 thrombus thrombus NN cord-266948-n7sltd1b 58 41 removal removal NN cord-266948-n7sltd1b 58 42 in in IN cord-266948-n7sltd1b 58 43 stroke stroke NN cord-266948-n7sltd1b 58 44 patients patient NNS cord-266948-n7sltd1b 58 45 . . . cord-266948-n7sltd1b 59 1 Thus thus RB cord-266948-n7sltd1b 59 2 , , , cord-266948-n7sltd1b 59 3 caution caution NN cord-266948-n7sltd1b 59 4 should should MD cord-266948-n7sltd1b 59 5 be be VB cord-266948-n7sltd1b 59 6 taken take VBN cord-266948-n7sltd1b 59 7 if if IN cord-266948-n7sltd1b 59 8 these these DT cord-266948-n7sltd1b 59 9 procedures procedure NNS cord-266948-n7sltd1b 59 10 are be VBP cord-266948-n7sltd1b 59 11 deemed deem VBN cord-266948-n7sltd1b 59 12 necessary necessary JJ cord-266948-n7sltd1b 59 13 ; ; : cord-266948-n7sltd1b 59 14 in in IN cord-266948-n7sltd1b 59 15 particular particular JJ cord-266948-n7sltd1b 59 16 , , , cord-266948-n7sltd1b 59 17 thrombosis thrombosis NN cord-266948-n7sltd1b 59 18 and and CC cord-266948-n7sltd1b 59 19 the the DT cord-266948-n7sltd1b 59 20 effects effect NNS cord-266948-n7sltd1b 59 21 of of IN cord-266948-n7sltd1b 59 22 anticoagulants anticoagulant NNS cord-266948-n7sltd1b 59 23 on on IN cord-266948-n7sltd1b 59 24 bleeding bleeding NN cord-266948-n7sltd1b 59 25 must must MD cord-266948-n7sltd1b 59 26 be be VB cord-266948-n7sltd1b 59 27 carefully carefully RB cord-266948-n7sltd1b 59 28 monitored monitor VBN cord-266948-n7sltd1b 59 29 . . . cord-266948-n7sltd1b 60 1 Transcatheter Transcatheter NNP cord-266948-n7sltd1b 60 2 versus versus IN cord-266948-n7sltd1b 60 3 surgical surgical JJ cord-266948-n7sltd1b 60 4 aortic aortic JJ cord-266948-n7sltd1b 60 5 - - HYPH cord-266948-n7sltd1b 60 6 valve valve NN cord-266948-n7sltd1b 60 7 replacement replacement NN cord-266948-n7sltd1b 60 8 in in IN cord-266948-n7sltd1b 60 9 high high JJ cord-266948-n7sltd1b 60 10 - - HYPH cord-266948-n7sltd1b 60 11 risk risk NN cord-266948-n7sltd1b 60 12 patients patient NNS cord-266948-n7sltd1b 60 13 Complement complement VB cord-266948-n7sltd1b 60 14 associated associate VBD cord-266948-n7sltd1b 60 15 microvascular microvascular JJ cord-266948-n7sltd1b 60 16 injury injury NN cord-266948-n7sltd1b 60 17 and and CC cord-266948-n7sltd1b 60 18 thrombosis thrombosis NN cord-266948-n7sltd1b 60 19 in in IN cord-266948-n7sltd1b 60 20 the the DT cord-266948-n7sltd1b 60 21 pathogenesis pathogenesis NN cord-266948-n7sltd1b 60 22 of of IN cord-266948-n7sltd1b 60 23 severe severe JJ cord-266948-n7sltd1b 60 24 COVID-19 covid-19 JJ cord-266948-n7sltd1b 60 25 infection infection NN cord-266948-n7sltd1b 60 26 : : : cord-266948-n7sltd1b 61 1 a a DT cord-266948-n7sltd1b 61 2 report report NN cord-266948-n7sltd1b 61 3 of of IN cord-266948-n7sltd1b 61 4 five five CD cord-266948-n7sltd1b 61 5 cases case NNS cord-266948-n7sltd1b 61 6 COVID-19 covid-19 VBP cord-266948-n7sltd1b 61 7 and and CC cord-266948-n7sltd1b 61 8 its -PRON- PRP$ cord-266948-n7sltd1b 61 9 implications implication NNS cord-266948-n7sltd1b 61 10 for for IN cord-266948-n7sltd1b 61 11 thrombosis thrombosis NN cord-266948-n7sltd1b 61 12 and and CC cord-266948-n7sltd1b 61 13 anticoagulation anticoagulation NN cord-266948-n7sltd1b 61 14 How how WRB cord-266948-n7sltd1b 61 15 to to TO cord-266948-n7sltd1b 61 16 handle handle VB cord-266948-n7sltd1b 61 17 elective elective JJ cord-266948-n7sltd1b 61 18 surgeries surgery NNS cord-266948-n7sltd1b 61 19 and and CC cord-266948-n7sltd1b 61 20 procedures procedure NNS cord-266948-n7sltd1b 61 21 during during IN cord-266948-n7sltd1b 61 22 the the DT cord-266948-n7sltd1b 61 23 COVID-19 COVID-19 NNP cord-266948-n7sltd1b 61 24 pandemic pandemic NN cord-266948-n7sltd1b 61 25 . . . cord-266948-n7sltd1b 62 1 The the DT cord-266948-n7sltd1b 62 2 National National NNP cord-266948-n7sltd1b 62 3 Law Law NNP cord-266948-n7sltd1b 62 4 Review Review NNP cord-266948-n7sltd1b 62 5 Circuit Circuit NNP cord-266948-n7sltd1b 62 6 thrombosis thrombosis NN cord-266948-n7sltd1b 62 7 reversed reverse VBD cord-266948-n7sltd1b 62 8 and and CC cord-266948-n7sltd1b 62 9 markers marker NNS cord-266948-n7sltd1b 62 10 of of IN cord-266948-n7sltd1b 62 11 a a DT cord-266948-n7sltd1b 62 12 hypercoagulable hypercoagulable JJ cord-266948-n7sltd1b 62 13 state state NN cord-266948-n7sltd1b 62 14 decreased decrease VBN cord-266948-n7sltd1b 62 15 by by IN cord-266948-n7sltd1b 62 16 direct direct JJ cord-266948-n7sltd1b 62 17 thrombin thrombin NN cord-266948-n7sltd1b 62 18 inhibition inhibition NN cord-266948-n7sltd1b 62 19 in in IN cord-266948-n7sltd1b 62 20 COVID-19 COVID-19 NNP cord-266948-n7sltd1b 62 21 Acute acute JJ cord-266948-n7sltd1b 62 22 thrombosis thrombosis NN cord-266948-n7sltd1b 62 23 of of IN cord-266948-n7sltd1b 62 24 an an DT cord-266948-n7sltd1b 62 25 aortic aortic JJ cord-266948-n7sltd1b 62 26 prosthetic prosthetic JJ cord-266948-n7sltd1b 62 27 graft graft NN cord-266948-n7sltd1b 62 28 in in IN cord-266948-n7sltd1b 62 29 a a DT cord-266948-n7sltd1b 62 30 patient patient NN cord-266948-n7sltd1b 62 31 with with IN cord-266948-n7sltd1b 62 32 severe severe JJ cord-266948-n7sltd1b 62 33 COVID-19-Related covid-19-related JJ cord-266948-n7sltd1b 62 34 pneumonia pneumonia NN cord-266948-n7sltd1b 63 1 Elevated elevated JJ cord-266948-n7sltd1b 63 2 D d NN cord-266948-n7sltd1b 63 3 - - HYPH cord-266948-n7sltd1b 63 4 dimer dimer NN cord-266948-n7sltd1b 63 5 levels level NNS cord-266948-n7sltd1b 63 6 are be VBP cord-266948-n7sltd1b 63 7 associated associate VBN cord-266948-n7sltd1b 63 8 with with IN cord-266948-n7sltd1b 63 9 increased increase VBN cord-266948-n7sltd1b 63 10 risk risk NN cord-266948-n7sltd1b 63 11 of of IN cord-266948-n7sltd1b 63 12 mortality mortality NN cord-266948-n7sltd1b 63 13 in in IN cord-266948-n7sltd1b 63 14 COVID-19 COVID-19 NNP cord-266948-n7sltd1b 63 15 : : : cord-266948-n7sltd1b 63 16 a a DT cord-266948-n7sltd1b 63 17 systematic systematic JJ cord-266948-n7sltd1b 63 18 review review NN cord-266948-n7sltd1b 63 19 and and CC cord-266948-n7sltd1b 63 20 meta meta NNP cord-266948-n7sltd1b 63 21 - - HYPH cord-266948-n7sltd1b 63 22 analysis analysis NN cord-266948-n7sltd1b 63 23 Inhibitors Inhibitors NNPS cord-266948-n7sltd1b 63 24 of of IN cord-266948-n7sltd1b 63 25 the the DT cord-266948-n7sltd1b 63 26 reninangiotensin reninangiotensin JJ cord-266948-n7sltd1b 63 27 - - HYPH cord-266948-n7sltd1b 63 28 aldosterone aldosterone NN cord-266948-n7sltd1b 63 29 system system NN cord-266948-n7sltd1b 63 30 and and CC cord-266948-n7sltd1b 63 31 Covid-19 Covid-19 NNP cord-266948-n7sltd1b 63 32 Inactivation Inactivation NNP cord-266948-n7sltd1b 63 33 of of IN cord-266948-n7sltd1b 63 34 plateletderived plateletderived JJ cord-266948-n7sltd1b 63 35 TGF TGF NNP cord-266948-n7sltd1b 63 36 - - HYPH cord-266948-n7sltd1b 63 37 β1 β1 NNP cord-266948-n7sltd1b 63 38 attenuates attenuate VBZ cord-266948-n7sltd1b 63 39 aortic aortic JJ cord-266948-n7sltd1b 63 40 stenosis stenosis NN cord-266948-n7sltd1b 63 41 progression progression NN cord-266948-n7sltd1b 63 42 in in IN cord-266948-n7sltd1b 63 43 a a DT cord-266948-n7sltd1b 63 44 robust robust JJ cord-266948-n7sltd1b 63 45 murine murine JJ cord-266948-n7sltd1b 63 46 model model NN cord-266948-n7sltd1b 64 1 The the DT cord-266948-n7sltd1b 64 2 pathogenicity pathogenicity NN cord-266948-n7sltd1b 64 3 of of IN cord-266948-n7sltd1b 64 4 SARS SARS NNP cord-266948-n7sltd1b 64 5 - - HYPH cord-266948-n7sltd1b 64 6 CoV-2 CoV-2 NNP cord-266948-n7sltd1b 64 7 in in IN cord-266948-n7sltd1b 64 8 hACE2 hace2 NN cord-266948-n7sltd1b 64 9 transgenic transgenic JJ cord-266948-n7sltd1b 64 10 mice mouse NNS cord-266948-n7sltd1b 65 1 Acknowledgements acknowledgement NNS cord-266948-n7sltd1b 66 1 The the DT cord-266948-n7sltd1b 66 2 authors author NNS cord-266948-n7sltd1b 66 3 would would MD cord-266948-n7sltd1b 66 4 like like VB cord-266948-n7sltd1b 66 5 to to TO cord-266948-n7sltd1b 66 6 thank thank VB cord-266948-n7sltd1b 66 7 Life Life NNP cord-266948-n7sltd1b 66 8 Science Science NNP cord-266948-n7sltd1b 66 9 Editors Editors NNPS cord-266948-n7sltd1b 66 10 and and CC cord-266948-n7sltd1b 66 11 M M NNP cord-266948-n7sltd1b 66 12 K K NNP cord-266948-n7sltd1b 66 13 Occhipinti Occhipinti NNP cord-266948-n7sltd1b 66 14 for for IN cord-266948-n7sltd1b 66 15 editing edit VBG cord-266948-n7sltd1b 66 16 the the DT cord-266948-n7sltd1b 66 17 manuscript manuscript NN cord-266948-n7sltd1b 66 18 and and CC cord-266948-n7sltd1b 66 19 Dr Dr NNP cord-266948-n7sltd1b 66 20 J J NNP cord-266948-n7sltd1b 66 21 Laurence Laurence NNP cord-266948-n7sltd1b 66 22 , , , cord-266948-n7sltd1b 66 23 MD MD NNP cord-266948-n7sltd1b 66 24 , , , cord-266948-n7sltd1b 66 25 for for IN cord-266948-n7sltd1b 66 26 his -PRON- PRP$ cord-266948-n7sltd1b 66 27 critical critical JJ cord-266948-n7sltd1b 66 28 comments comment NNS cord-266948-n7sltd1b 66 29 . . . cord-266948-n7sltd1b 67 1 Contributors contributor NNS cord-266948-n7sltd1b 67 2 JA JA NNP cord-266948-n7sltd1b 67 3 conceive conceive VBP cord-266948-n7sltd1b 67 4 the the DT cord-266948-n7sltd1b 67 5 idea idea NN cord-266948-n7sltd1b 67 6 and and CC cord-266948-n7sltd1b 67 7 wrote write VBD cord-266948-n7sltd1b 67 8 the the DT cord-266948-n7sltd1b 67 9 manuscript manuscript NN cord-266948-n7sltd1b 67 10 . . . cord-266948-n7sltd1b 68 1 Funding funding NN cord-266948-n7sltd1b 69 1 The the DT cord-266948-n7sltd1b 69 2 work work NN cord-266948-n7sltd1b 69 3 of of IN cord-266948-n7sltd1b 69 4 the the DT cord-266948-n7sltd1b 69 5 author author NN cord-266948-n7sltd1b 69 6 herein herein RB cord-266948-n7sltd1b 69 7 is be VBZ cord-266948-n7sltd1b 69 8 supported support VBN cord-266948-n7sltd1b 69 9 by by IN cord-266948-n7sltd1b 69 10 NHLBI NHLBI NNP cord-266948-n7sltd1b 69 11 grant grant NN cord-266948-n7sltd1b 69 12 # # NN cord-266948-n7sltd1b 69 13 HL123605 hl123605 NN cord-266948-n7sltd1b 69 14 and and CC cord-266948-n7sltd1b 69 15 HL148123 hl148123 NN cord-266948-n7sltd1b 69 16 ( ( -LRB- cord-266948-n7sltd1b 69 17 JA JA NNP cord-266948-n7sltd1b 69 18 ) ) -RRB- cord-266948-n7sltd1b 69 19 and and CC cord-266948-n7sltd1b 70 1 the the DT cord-266948-n7sltd1b 70 2 laboratory laboratory NN cord-266948-n7sltd1b 70 3 of of IN cord-266948-n7sltd1b 70 4 JA JA NNP cord-266948-n7sltd1b 70 5 was be VBD cord-266948-n7sltd1b 70 6 supported support VBN cord-266948-n7sltd1b 70 7 by by IN cord-266948-n7sltd1b 70 8 GM114731 GM114731 NNP cord-266948-n7sltd1b 70 9 , , , cord-266948-n7sltd1b 70 10 CA213987 CA213987 NNP cord-266948-n7sltd1b 70 11 , , , cord-266948-n7sltd1b 70 12 OCASCR OCASCR NNP cord-266948-n7sltd1b 70 13 and and CC cord-266948-n7sltd1b 70 14 PHF PHF NNP cord-266948-n7sltd1b 70 15 grants grant NNS cord-266948-n7sltd1b 70 16 . . . cord-266948-n7sltd1b 71 1 Ahamed Ahamed NNP cord-266948-n7sltd1b 71 2 J. J. NNP cord-266948-n7sltd1b 71 3 Open Open NNP cord-266948-n7sltd1b 71 4 Heart Heart NNP cord-266948-n7sltd1b 72 1 2020;7 2020;7 LS cord-266948-n7sltd1b 72 2 : : : cord-266948-n7sltd1b 73 1 e001355 e001355 NNP cord-266948-n7sltd1b 73 2 . . . cord-266948-n7sltd1b 74 1 doi:10.1136 doi:10.1136 NNP cord-266948-n7sltd1b 74 2 / / SYM cord-266948-n7sltd1b 74 3 openhrt-2020 openhrt-2020 NN cord-266948-n7sltd1b 74 4 - - HYPH cord-266948-n7sltd1b 74 5 001355 001355 CD cord-266948-n7sltd1b 75 1 Viewpoint viewpoint NN cord-266948-n7sltd1b 75 2 ORCID ORCID NNP cord-266948-n7sltd1b 75 3 iD iD NNP cord-266948-n7sltd1b 76 1 Jasimuddin Jasimuddin NNP cord-266948-n7sltd1b 76 2 Ahamed Ahamed NNP cord-266948-n7sltd1b 76 3 http:// http:// NN cord-266948-n7sltd1b 76 4 orcid orcid JJ cord-266948-n7sltd1b 76 5 . . . cord-266948-n7sltd1b 77 1 org/ org/ NNP cord-266948-n7sltd1b 77 2 0000 0000 CD cord-266948-n7sltd1b 77 3 - - HYPH cord-266948-n7sltd1b 77 4 0001 0001 CD cord-266948-n7sltd1b 78 1 -6455 -6455 : cord-266948-n7sltd1b 78 2 - - JJ cord-266948-n7sltd1b 78 3 0296 0296 CD cord-266948-n7sltd1b 79 1 Competing compete VBG cord-266948-n7sltd1b 79 2 interests interest NNS cord-266948-n7sltd1b 79 3 None None NNP cord-266948-n7sltd1b 79 4 declared declare VBD cord-266948-n7sltd1b 79 5 . . .