id sid tid token lemma pos cord-265799-qda5awuc 1 1 key key JJ cord-265799-qda5awuc 2 1 : : : cord-265799-qda5awuc 2 2 cord-265799-qda5awuc cord-265799-qda5awuc JJ cord-265799-qda5awuc 2 3 authors author NNS cord-265799-qda5awuc 2 4 : : : cord-265799-qda5awuc 2 5 Carothers Carothers NNP cord-265799-qda5awuc 2 6 , , , cord-265799-qda5awuc 2 7 Chancey Chancey NNP cord-265799-qda5awuc 2 8 ; ; : cord-265799-qda5awuc 2 9 Birrer Birrer NNP cord-265799-qda5awuc 2 10 , , , cord-265799-qda5awuc 2 11 Kara Kara NNP cord-265799-qda5awuc 2 12 ; ; : cord-265799-qda5awuc 2 13 Vo Vo NNP cord-265799-qda5awuc 2 14 , , , cord-265799-qda5awuc 2 15 Mai Mai NNP cord-265799-qda5awuc 2 16 title title NN cord-265799-qda5awuc 2 17 : : : cord-265799-qda5awuc 2 18 Acetylcysteine acetylcysteine NN cord-265799-qda5awuc 2 19 for for IN cord-265799-qda5awuc 2 20 the the DT cord-265799-qda5awuc 2 21 Treatment Treatment NNP cord-265799-qda5awuc 2 22 of of IN cord-265799-qda5awuc 2 23 Suspected suspect VBN cord-265799-qda5awuc 2 24 Remdesivir‐Associated remdesivir‐associate VBN cord-265799-qda5awuc 2 25 Acute Acute NNP cord-265799-qda5awuc 2 26 Liver Liver NNP cord-265799-qda5awuc 2 27 Failure failure NN cord-265799-qda5awuc 2 28 in in IN cord-265799-qda5awuc 2 29 COVID‐19 covid‐19 NN cord-265799-qda5awuc 2 30 : : : cord-265799-qda5awuc 2 31 A a DT cord-265799-qda5awuc 2 32 Case Case NNP cord-265799-qda5awuc 2 33 Series Series NNP cord-265799-qda5awuc 2 34 date date NN cord-265799-qda5awuc 2 35 : : : cord-265799-qda5awuc 2 36 2020 2020 CD cord-265799-qda5awuc 2 37 - - SYM cord-265799-qda5awuc 2 38 10 10 CD cord-265799-qda5awuc 2 39 - - SYM cord-265799-qda5awuc 2 40 02 02 CD cord-265799-qda5awuc 2 41 journal journal NN cord-265799-qda5awuc 2 42 : : : cord-265799-qda5awuc 3 1 Pharmacotherapy Pharmacotherapy NNP cord-265799-qda5awuc 3 2 DOI DOI NNP cord-265799-qda5awuc 3 3 : : : cord-265799-qda5awuc 4 1 10.1002 10.1002 CD cord-265799-qda5awuc 4 2 / / SYM cord-265799-qda5awuc 4 3 phar.2464 phar.2464 NNP cord-265799-qda5awuc 4 4 sha sha NNP cord-265799-qda5awuc 4 5 : : : cord-265799-qda5awuc 5 1 ecafc1c8a346dc88a20612edcc48a34e200723ac ecafc1c8a346dc88a20612edcc48a34e200723ac NNP cord-265799-qda5awuc 5 2 doc_id doc_id CD cord-265799-qda5awuc 6 1 : : : cord-265799-qda5awuc 6 2 265799 265799 CD cord-265799-qda5awuc 6 3 cord_uid cord_uid NNS cord-265799-qda5awuc 6 4 : : : cord-265799-qda5awuc 7 1 qda5awuc qda5awuc NNP cord-265799-qda5awuc 7 2 Remdesivir Remdesivir NNP cord-265799-qda5awuc 7 3 is be VBZ cord-265799-qda5awuc 7 4 a a DT cord-265799-qda5awuc 7 5 direct‐acting direct‐acte VBG cord-265799-qda5awuc 7 6 nucleoside nucleoside NN cord-265799-qda5awuc 7 7 RNA RNA NNP cord-265799-qda5awuc 7 8 polymerase polymerase NN cord-265799-qda5awuc 7 9 inhibitor inhibitor NN cord-265799-qda5awuc 7 10 with with IN cord-265799-qda5awuc 7 11 activity activity NN cord-265799-qda5awuc 7 12 against against IN cord-265799-qda5awuc 7 13 the the DT cord-265799-qda5awuc 7 14 novel novel JJ cord-265799-qda5awuc 7 15 SARS‐CoV‐2 SARS‐CoV‐2 NNP cord-265799-qda5awuc 7 16 virus virus NN cord-265799-qda5awuc 7 17 used use VBN cord-265799-qda5awuc 7 18 in in IN cord-265799-qda5awuc 7 19 the the DT cord-265799-qda5awuc 7 20 treatment treatment NN cord-265799-qda5awuc 7 21 of of IN cord-265799-qda5awuc 7 22 COVID‐19 COVID‐19 NNP cord-265799-qda5awuc 7 23 pneumonia pneumonia NN cord-265799-qda5awuc 7 24 . . . cord-265799-qda5awuc 8 1 Here here RB cord-265799-qda5awuc 8 2 we -PRON- PRP cord-265799-qda5awuc 8 3 present present VBP cord-265799-qda5awuc 8 4 two two CD cord-265799-qda5awuc 8 5 cases case NNS cord-265799-qda5awuc 8 6 of of IN cord-265799-qda5awuc 8 7 suspected suspect VBN cord-265799-qda5awuc 8 8 remdesivir‐associated remdesivir‐associated JJ cord-265799-qda5awuc 8 9 acute acute JJ cord-265799-qda5awuc 8 10 liver liver NN cord-265799-qda5awuc 8 11 failure failure NN cord-265799-qda5awuc 8 12 ( ( -LRB- cord-265799-qda5awuc 8 13 ALF ALF NNP cord-265799-qda5awuc 8 14 ) ) -RRB- cord-265799-qda5awuc 8 15 in in IN cord-265799-qda5awuc 8 16 which which WDT cord-265799-qda5awuc 8 17 the the DT cord-265799-qda5awuc 8 18 liver liver NN cord-265799-qda5awuc 8 19 failure failure NN cord-265799-qda5awuc 8 20 improved improve VBD cord-265799-qda5awuc 8 21 following follow VBG cord-265799-qda5awuc 8 22 continuous continuous JJ cord-265799-qda5awuc 8 23 infusion infusion NN cord-265799-qda5awuc 8 24 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 8 25 and and CC cord-265799-qda5awuc 8 26 withdrawal withdrawal NN cord-265799-qda5awuc 8 27 of of IN cord-265799-qda5awuc 8 28 remdesivir remdesivir NNP cord-265799-qda5awuc 8 29 . . . cord-265799-qda5awuc 9 1 Both both DT cord-265799-qda5awuc 9 2 patients patient NNS cord-265799-qda5awuc 9 3 had have VBD cord-265799-qda5awuc 9 4 significant significant JJ cord-265799-qda5awuc 9 5 increases increase NNS cord-265799-qda5awuc 9 6 in in IN cord-265799-qda5awuc 9 7 transaminases transaminase NNS cord-265799-qda5awuc 9 8 between between IN cord-265799-qda5awuc 9 9 day day NN cord-265799-qda5awuc 9 10 3 3 CD cord-265799-qda5awuc 9 11 and and CC cord-265799-qda5awuc 9 12 day day NN cord-265799-qda5awuc 9 13 10 10 CD cord-265799-qda5awuc 9 14 of of IN cord-265799-qda5awuc 9 15 remdesivir remdesivir NNP cord-265799-qda5awuc 9 16 therapy therapy NN cord-265799-qda5awuc 9 17 accompanied accompany VBN cord-265799-qda5awuc 9 18 by by IN cord-265799-qda5awuc 9 19 coagulopathy coagulopathy NN cord-265799-qda5awuc 9 20 and and CC cord-265799-qda5awuc 9 21 encephalopathy encephalopathy NN cord-265799-qda5awuc 9 22 . . . cord-265799-qda5awuc 10 1 After after IN cord-265799-qda5awuc 10 2 initiation initiation NN cord-265799-qda5awuc 10 3 of of IN cord-265799-qda5awuc 10 4 continuous continuous JJ cord-265799-qda5awuc 10 5 infusion infusion NN cord-265799-qda5awuc 10 6 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 10 7 , , , cord-265799-qda5awuc 10 8 the the DT cord-265799-qda5awuc 10 9 transaminases transaminase NNS cord-265799-qda5awuc 10 10 of of IN cord-265799-qda5awuc 10 11 both both DT cord-265799-qda5awuc 10 12 patients patient NNS cord-265799-qda5awuc 10 13 rapidly rapidly RB cord-265799-qda5awuc 10 14 improved improve VBD cord-265799-qda5awuc 10 15 . . . cord-265799-qda5awuc 11 1 Ultimately ultimately RB cord-265799-qda5awuc 11 2 one one CD cord-265799-qda5awuc 11 3 patient patient NN cord-265799-qda5awuc 11 4 fully fully RB cord-265799-qda5awuc 11 5 recovered recover VBD cord-265799-qda5awuc 11 6 while while IN cord-265799-qda5awuc 11 7 the the DT cord-265799-qda5awuc 11 8 other other JJ cord-265799-qda5awuc 11 9 died die VBD cord-265799-qda5awuc 11 10 of of IN cord-265799-qda5awuc 11 11 suspected suspect VBN cord-265799-qda5awuc 11 12 septic septic JJ cord-265799-qda5awuc 11 13 shock shock NN cord-265799-qda5awuc 11 14 . . . cord-265799-qda5awuc 12 1 Due due IN cord-265799-qda5awuc 12 2 to to IN cord-265799-qda5awuc 12 3 its -PRON- PRP$ cord-265799-qda5awuc 12 4 novel novel JJ cord-265799-qda5awuc 12 5 nature nature NN cord-265799-qda5awuc 12 6 and and CC cord-265799-qda5awuc 12 7 only only RB cord-265799-qda5awuc 12 8 recent recent JJ cord-265799-qda5awuc 12 9 widespread widespread JJ cord-265799-qda5awuc 12 10 use use NN cord-265799-qda5awuc 12 11 , , , cord-265799-qda5awuc 12 12 there there EX cord-265799-qda5awuc 12 13 is be VBZ cord-265799-qda5awuc 12 14 very very RB cord-265799-qda5awuc 12 15 little little JJ cord-265799-qda5awuc 12 16 data datum NNS cord-265799-qda5awuc 12 17 on on IN cord-265799-qda5awuc 12 18 the the DT cord-265799-qda5awuc 12 19 risk risk NN cord-265799-qda5awuc 12 20 of of IN cord-265799-qda5awuc 12 21 ALF ALF NNP cord-265799-qda5awuc 12 22 from from IN cord-265799-qda5awuc 12 23 remdesivir remdesivir NNP cord-265799-qda5awuc 12 24 . . . cord-265799-qda5awuc 13 1 Additionally additionally RB cord-265799-qda5awuc 13 2 , , , cord-265799-qda5awuc 13 3 the the DT cord-265799-qda5awuc 13 4 data datum NNS cord-265799-qda5awuc 13 5 for for IN cord-265799-qda5awuc 13 6 the the DT cord-265799-qda5awuc 13 7 use use NN cord-265799-qda5awuc 13 8 of of IN cord-265799-qda5awuc 13 9 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 13 10 to to TO cord-265799-qda5awuc 13 11 manage manage VB cord-265799-qda5awuc 13 12 non‐acetaminophen‐induced non‐acetaminophen‐induced NNP cord-265799-qda5awuc 13 13 ALF ALF NNP cord-265799-qda5awuc 13 14 is be VBZ cord-265799-qda5awuc 13 15 limited limit VBN cord-265799-qda5awuc 13 16 . . . cord-265799-qda5awuc 14 1 It -PRON- PRP cord-265799-qda5awuc 14 2 is be VBZ cord-265799-qda5awuc 14 3 important important JJ cord-265799-qda5awuc 14 4 to to TO cord-265799-qda5awuc 14 5 consider consider VB cord-265799-qda5awuc 14 6 the the DT cord-265799-qda5awuc 14 7 risk risk NN cord-265799-qda5awuc 14 8 of of IN cord-265799-qda5awuc 14 9 remdesivir‐associated remdesivir‐associated JJ cord-265799-qda5awuc 14 10 ALF ALF NNP cord-265799-qda5awuc 14 11 when when WRB cord-265799-qda5awuc 14 12 weighing weigh VBG cord-265799-qda5awuc 14 13 the the DT cord-265799-qda5awuc 14 14 risk risk NN cord-265799-qda5awuc 14 15 vs. vs. IN cord-265799-qda5awuc 14 16 benefits benefit NNS cord-265799-qda5awuc 14 17 of of IN cord-265799-qda5awuc 14 18 use use NN cord-265799-qda5awuc 14 19 , , , cord-265799-qda5awuc 14 20 and and CC cord-265799-qda5awuc 14 21 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 14 22 may may MD cord-265799-qda5awuc 14 23 have have VB cord-265799-qda5awuc 14 24 a a DT cord-265799-qda5awuc 14 25 role role NN cord-265799-qda5awuc 14 26 in in IN cord-265799-qda5awuc 14 27 its -PRON- PRP$ cord-265799-qda5awuc 14 28 management management NN cord-265799-qda5awuc 14 29 . . . cord-265799-qda5awuc 15 1 has have VBZ cord-265799-qda5awuc 15 2 been be VBN cord-265799-qda5awuc 15 3 made make VBN cord-265799-qda5awuc 15 4 available available JJ cord-265799-qda5awuc 15 5 for for IN cord-265799-qda5awuc 15 6 clinical clinical JJ cord-265799-qda5awuc 15 7 use use NN cord-265799-qda5awuc 15 8 through through IN cord-265799-qda5awuc 15 9 an an DT cord-265799-qda5awuc 15 10 Emergency Emergency NNP cord-265799-qda5awuc 15 11 Use Use NNP cord-265799-qda5awuc 15 12 Authorization Authorization NNP cord-265799-qda5awuc 15 13 ( ( -LRB- cord-265799-qda5awuc 15 14 EUA EUA NNP cord-265799-qda5awuc 15 15 ) ) -RRB- cord-265799-qda5awuc 15 16 program program NN cord-265799-qda5awuc 15 17 through through IN cord-265799-qda5awuc 15 18 the the DT cord-265799-qda5awuc 15 19 FDA FDA NNP cord-265799-qda5awuc 15 20 . . . cord-265799-qda5awuc 16 1 In in IN cord-265799-qda5awuc 16 2 both both DT cord-265799-qda5awuc 16 3 pre pre JJ cord-265799-qda5awuc 16 4 - - JJ cord-265799-qda5awuc 16 5 clinical clinical JJ cord-265799-qda5awuc 16 6 and and CC cord-265799-qda5awuc 16 7 clinical clinical JJ cord-265799-qda5awuc 16 8 studies study NNS cord-265799-qda5awuc 16 9 , , , cord-265799-qda5awuc 16 10 non non JJ cord-265799-qda5awuc 16 11 - - JJ cord-265799-qda5awuc 16 12 serious serious JJ cord-265799-qda5awuc 16 13 elevations elevation NNS cord-265799-qda5awuc 16 14 of of IN cord-265799-qda5awuc 16 15 both both DT cord-265799-qda5awuc 16 16 aspartate aspartate NN cord-265799-qda5awuc 16 17 transaminase transaminase FW cord-265799-qda5awuc 16 18 ( ( -LRB- cord-265799-qda5awuc 16 19 AST AST NNP cord-265799-qda5awuc 16 20 ) ) -RRB- cord-265799-qda5awuc 16 21 and and CC cord-265799-qda5awuc 16 22 alanine alanine NN cord-265799-qda5awuc 16 23 transaminase transaminase FW cord-265799-qda5awuc 16 24 ( ( -LRB- cord-265799-qda5awuc 16 25 ALT ALT NNP cord-265799-qda5awuc 16 26 ) ) -RRB- cord-265799-qda5awuc 16 27 were be VBD cord-265799-qda5awuc 16 28 noted note VBN cord-265799-qda5awuc 16 29 , , , cord-265799-qda5awuc 16 30 and and CC cord-265799-qda5awuc 16 31 the the DT cord-265799-qda5awuc 16 32 EUA EUA NNP cord-265799-qda5awuc 16 33 fact fact NN cord-265799-qda5awuc 16 34 sheet sheet NN cord-265799-qda5awuc 16 35 also also RB cord-265799-qda5awuc 16 36 reports report VBZ cord-265799-qda5awuc 16 37 that that IN cord-265799-qda5awuc 16 38 there there EX cord-265799-qda5awuc 16 39 have have VBP cord-265799-qda5awuc 16 40 been be VBN cord-265799-qda5awuc 16 41 several several JJ cord-265799-qda5awuc 16 42 cases case NNS cord-265799-qda5awuc 16 43 of of IN cord-265799-qda5awuc 16 44 severe severe JJ cord-265799-qda5awuc 16 45 liver liver NN cord-265799-qda5awuc 16 46 - - HYPH cord-265799-qda5awuc 16 47 related relate VBN cord-265799-qda5awuc 16 48 laboratory laboratory NN cord-265799-qda5awuc 16 49 abnormalities abnormality NNS cord-265799-qda5awuc 16 50 . . . cord-265799-qda5awuc 17 1 7 7 CD cord-265799-qda5awuc 18 1 The the DT cord-265799-qda5awuc 18 2 EUA EUA NNP cord-265799-qda5awuc 18 3 program program NN cord-265799-qda5awuc 18 4 includes include VBZ cord-265799-qda5awuc 18 5 monitoring monitoring NN cord-265799-qda5awuc 18 6 of of IN cord-265799-qda5awuc 18 7 both both CC cord-265799-qda5awuc 18 8 AST AST NNP cord-265799-qda5awuc 18 9 and and CC cord-265799-qda5awuc 18 10 ALT ALT NNP cord-265799-qda5awuc 18 11 as as IN cord-265799-qda5awuc 18 12 a a DT cord-265799-qda5awuc 18 13 requirement requirement NN cord-265799-qda5awuc 18 14 for for IN cord-265799-qda5awuc 18 15 use use NN cord-265799-qda5awuc 18 16 in in IN cord-265799-qda5awuc 18 17 patients patient NNS cord-265799-qda5awuc 18 18 , , , cord-265799-qda5awuc 18 19 with with IN cord-265799-qda5awuc 18 20 a a DT cord-265799-qda5awuc 18 21 focus focus NN cord-265799-qda5awuc 18 22 on on IN cord-265799-qda5awuc 18 23 ALT ALT NNP cord-265799-qda5awuc 18 24 . . . cord-265799-qda5awuc 19 1 We -PRON- PRP cord-265799-qda5awuc 19 2 report report VBP cord-265799-qda5awuc 19 3 two two CD cord-265799-qda5awuc 19 4 cases case NNS cord-265799-qda5awuc 19 5 of of IN cord-265799-qda5awuc 19 6 suspected suspect VBN cord-265799-qda5awuc 19 7 remdesivirassociated remdesivirassociated JJ cord-265799-qda5awuc 19 8 acute acute JJ cord-265799-qda5awuc 19 9 liver liver NN cord-265799-qda5awuc 19 10 failure failure NN cord-265799-qda5awuc 19 11 ( ( -LRB- cord-265799-qda5awuc 19 12 ALF ALF NNP cord-265799-qda5awuc 19 13 ) ) -RRB- cord-265799-qda5awuc 19 14 in in IN cord-265799-qda5awuc 19 15 patients patient NNS cord-265799-qda5awuc 19 16 with with IN cord-265799-qda5awuc 19 17 COVID-19 COVID-19 NNP cord-265799-qda5awuc 19 18 in in IN cord-265799-qda5awuc 19 19 which which WDT cord-265799-qda5awuc 19 20 the the DT cord-265799-qda5awuc 19 21 liver liver NN cord-265799-qda5awuc 19 22 failure failure NN cord-265799-qda5awuc 19 23 improved improve VBN cord-265799-qda5awuc 19 24 with with IN cord-265799-qda5awuc 19 25 the the DT cord-265799-qda5awuc 19 26 addition addition NN cord-265799-qda5awuc 19 27 of of IN cord-265799-qda5awuc 19 28 continuous continuous JJ cord-265799-qda5awuc 19 29 infusion infusion NN cord-265799-qda5awuc 19 30 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 19 31 and and CC cord-265799-qda5awuc 19 32 discontinuation discontinuation NN cord-265799-qda5awuc 19 33 of of IN cord-265799-qda5awuc 19 34 potentially potentially RB cord-265799-qda5awuc 19 35 hepatotoxic hepatotoxic JJ cord-265799-qda5awuc 19 36 medications medication NNS cord-265799-qda5awuc 19 37 . . . cord-265799-qda5awuc 20 1 Case case NN cord-265799-qda5awuc 20 2 # # NN cord-265799-qda5awuc 20 3 1 1 CD cord-265799-qda5awuc 20 4 : : : cord-265799-qda5awuc 20 5 A a DT cord-265799-qda5awuc 20 6 68-year 68-year JJ cord-265799-qda5awuc 20 7 - - HYPH cord-265799-qda5awuc 20 8 old old JJ cord-265799-qda5awuc 20 9 female female NN cord-265799-qda5awuc 20 10 with with IN cord-265799-qda5awuc 20 11 a a DT cord-265799-qda5awuc 20 12 history history NN cord-265799-qda5awuc 20 13 of of IN cord-265799-qda5awuc 20 14 hypertension hypertension NN cord-265799-qda5awuc 20 15 , , , cord-265799-qda5awuc 20 16 diabetes diabetes NN cord-265799-qda5awuc 20 17 mellitus mellitus NN cord-265799-qda5awuc 20 18 , , , cord-265799-qda5awuc 20 19 hyperlipidemia hyperlipidemia NN cord-265799-qda5awuc 20 20 , , , cord-265799-qda5awuc 20 21 and and CC cord-265799-qda5awuc 20 22 coronary coronary JJ cord-265799-qda5awuc 20 23 artery artery NN cord-265799-qda5awuc 20 24 disease disease NN cord-265799-qda5awuc 20 25 ( ( -LRB- cord-265799-qda5awuc 20 26 CAD CAD NNP cord-265799-qda5awuc 20 27 ) ) -RRB- cord-265799-qda5awuc 20 28 presented present VBD cord-265799-qda5awuc 20 29 to to IN cord-265799-qda5awuc 20 30 an an DT cord-265799-qda5awuc 20 31 outside outside JJ cord-265799-qda5awuc 20 32 hospital hospital NN cord-265799-qda5awuc 20 33 with with IN cord-265799-qda5awuc 20 34 a a DT cord-265799-qda5awuc 20 35 chief chief JJ cord-265799-qda5awuc 20 36 complaint complaint NN cord-265799-qda5awuc 20 37 of of IN cord-265799-qda5awuc 20 38 increasing increase VBG cord-265799-qda5awuc 20 39 shortness shortness NN cord-265799-qda5awuc 20 40 of of IN cord-265799-qda5awuc 20 41 breath breath NN cord-265799-qda5awuc 20 42 and and CC cord-265799-qda5awuc 20 43 tightness tightness NN cord-265799-qda5awuc 20 44 across across IN cord-265799-qda5awuc 20 45 her -PRON- PRP$ cord-265799-qda5awuc 20 46 chest chest NN cord-265799-qda5awuc 20 47 . . . cord-265799-qda5awuc 21 1 On on IN cord-265799-qda5awuc 21 2 admission admission NN cord-265799-qda5awuc 21 3 she -PRON- PRP cord-265799-qda5awuc 21 4 was be VBD cord-265799-qda5awuc 21 5 found find VBN cord-265799-qda5awuc 21 6 to to TO cord-265799-qda5awuc 21 7 have have VB cord-265799-qda5awuc 21 8 an an DT cord-265799-qda5awuc 21 9 oxygen oxygen NN cord-265799-qda5awuc 21 10 saturation saturation NN cord-265799-qda5awuc 21 11 in in IN cord-265799-qda5awuc 21 12 the the DT cord-265799-qda5awuc 21 13 70s 70 NNS cord-265799-qda5awuc 21 14 and and CC cord-265799-qda5awuc 21 15 a a DT cord-265799-qda5awuc 21 16 systolic systolic JJ cord-265799-qda5awuc 21 17 blood blood NN cord-265799-qda5awuc 21 18 pressure pressure NN cord-265799-qda5awuc 21 19 > > XX cord-265799-qda5awuc 21 20 200 200 CD cord-265799-qda5awuc 21 21 mmHg mmHg NNS cord-265799-qda5awuc 21 22 , , , cord-265799-qda5awuc 21 23 both both DT cord-265799-qda5awuc 21 24 treated treat VBN cord-265799-qda5awuc 21 25 with with IN cord-265799-qda5awuc 21 26 bilevel bilevel JJ cord-265799-qda5awuc 21 27 positive positive JJ cord-265799-qda5awuc 21 28 airway airway NN cord-265799-qda5awuc 21 29 pressure pressure NN cord-265799-qda5awuc 21 30 ventilation ventilation NN cord-265799-qda5awuc 21 31 ( ( -LRB- cord-265799-qda5awuc 21 32 BiPAP BiPAP NNP cord-265799-qda5awuc 21 33 ) ) -RRB- cord-265799-qda5awuc 21 34 and and CC cord-265799-qda5awuc 21 35 a a DT cord-265799-qda5awuc 21 36 nitroglycerin nitroglycerin NN cord-265799-qda5awuc 21 37 continuous continuous JJ cord-265799-qda5awuc 21 38 infusion infusion NN cord-265799-qda5awuc 21 39 , , , cord-265799-qda5awuc 21 40 respectively respectively RB cord-265799-qda5awuc 21 41 . . . cord-265799-qda5awuc 22 1 The the DT cord-265799-qda5awuc 22 2 patient patient NN cord-265799-qda5awuc 22 3 also also RB cord-265799-qda5awuc 22 4 reported report VBD cord-265799-qda5awuc 22 5 chills chill NNS cord-265799-qda5awuc 22 6 , , , cord-265799-qda5awuc 22 7 fatigue fatigue NN cord-265799-qda5awuc 22 8 , , , cord-265799-qda5awuc 22 9 and and CC cord-265799-qda5awuc 22 10 body body NN cord-265799-qda5awuc 22 11 aches ache NNS cord-265799-qda5awuc 22 12 for for IN cord-265799-qda5awuc 22 13 the the DT cord-265799-qda5awuc 22 14 past past JJ cord-265799-qda5awuc 22 15 few few JJ cord-265799-qda5awuc 22 16 days day NNS cord-265799-qda5awuc 22 17 but but CC cord-265799-qda5awuc 22 18 with with IN cord-265799-qda5awuc 22 19 no no DT cord-265799-qda5awuc 22 20 sick sick JJ cord-265799-qda5awuc 22 21 contacts contact NNS cord-265799-qda5awuc 22 22 or or CC cord-265799-qda5awuc 22 23 known know VBN cord-265799-qda5awuc 22 24 COVID-19 covid-19 JJ cord-265799-qda5awuc 22 25 exposure exposure NN cord-265799-qda5awuc 22 26 . . . cord-265799-qda5awuc 23 1 A a DT cord-265799-qda5awuc 23 2 chest chest NN cord-265799-qda5awuc 23 3 Xray Xray NNP cord-265799-qda5awuc 23 4 was be VBD cord-265799-qda5awuc 23 5 performed perform VBN cord-265799-qda5awuc 23 6 that that WDT cord-265799-qda5awuc 23 7 found find VBD cord-265799-qda5awuc 23 8 bilateral bilateral JJ cord-265799-qda5awuc 23 9 , , , cord-265799-qda5awuc 23 10 diffuse diffuse JJ cord-265799-qda5awuc 23 11 interstitial interstitial JJ cord-265799-qda5awuc 23 12 infiltrates infiltrate VBZ cord-265799-qda5awuc 23 13 consistent consistent JJ cord-265799-qda5awuc 23 14 with with IN cord-265799-qda5awuc 23 15 COVID-19 COVID-19 NNP cord-265799-qda5awuc 23 16 pneumonia pneumonia NN cord-265799-qda5awuc 23 17 , , , cord-265799-qda5awuc 23 18 but but CC cord-265799-qda5awuc 23 19 the the DT cord-265799-qda5awuc 23 20 COVID-19 covid-19 JJ cord-265799-qda5awuc 23 21 reverse reverse JJ cord-265799-qda5awuc 23 22 transcription transcription NN cord-265799-qda5awuc 23 23 polymerase polymerase NN cord-265799-qda5awuc 23 24 chain chain NN cord-265799-qda5awuc 23 25 reaction reaction NN cord-265799-qda5awuc 23 26 ( ( -LRB- cord-265799-qda5awuc 23 27 RT RT NNP cord-265799-qda5awuc 23 28 - - HYPH cord-265799-qda5awuc 23 29 PCR PCR NNP cord-265799-qda5awuc 23 30 ) ) -RRB- cord-265799-qda5awuc 23 31 performed perform VBN cord-265799-qda5awuc 23 32 on on IN cord-265799-qda5awuc 23 33 the the DT cord-265799-qda5awuc 23 34 day day NN cord-265799-qda5awuc 23 35 of of IN cord-265799-qda5awuc 23 36 admission admission NN cord-265799-qda5awuc 23 37 was be VBD cord-265799-qda5awuc 23 38 negative negative JJ cord-265799-qda5awuc 23 39 . . . cord-265799-qda5awuc 24 1 An an DT cord-265799-qda5awuc 24 2 initial initial JJ cord-265799-qda5awuc 24 3 troponin troponin NN cord-265799-qda5awuc 24 4 was be VBD cord-265799-qda5awuc 24 5 collected collect VBN cord-265799-qda5awuc 24 6 at at IN cord-265799-qda5awuc 24 7 a a DT cord-265799-qda5awuc 24 8 level level NN cord-265799-qda5awuc 24 9 of of IN cord-265799-qda5awuc 24 10 0.2 0.2 CD cord-265799-qda5awuc 24 11 ng ng NN cord-265799-qda5awuc 24 12 / / SYM cord-265799-qda5awuc 24 13 mL ml NN cord-265799-qda5awuc 24 14 that that WDT cord-265799-qda5awuc 24 15 increased increase VBD cord-265799-qda5awuc 24 16 to to IN cord-265799-qda5awuc 24 17 1.35 1.35 CD cord-265799-qda5awuc 24 18 ng ng NN cord-265799-qda5awuc 24 19 / / SYM cord-265799-qda5awuc 24 20 mL ml NN cord-265799-qda5awuc 24 21 over over IN cord-265799-qda5awuc 24 22 the the DT cord-265799-qda5awuc 24 23 course course NN cord-265799-qda5awuc 24 24 of of IN cord-265799-qda5awuc 24 25 24 24 CD cord-265799-qda5awuc 24 26 hours hour NNS cord-265799-qda5awuc 24 27 , , , cord-265799-qda5awuc 24 28 thought think VBD cord-265799-qda5awuc 24 29 to to TO cord-265799-qda5awuc 24 30 be be VB cord-265799-qda5awuc 24 31 a a DT cord-265799-qda5awuc 24 32 type type NN cord-265799-qda5awuc 24 33 II II NNP cord-265799-qda5awuc 24 34 non non JJ cord-265799-qda5awuc 24 35 - - JJ cord-265799-qda5awuc 24 36 ST st JJ cord-265799-qda5awuc 24 37 - - HYPH cord-265799-qda5awuc 24 38 elevation elevation NNP cord-265799-qda5awuc 24 39 myocardial myocardial JJ cord-265799-qda5awuc 24 40 infarction infarction NN cord-265799-qda5awuc 24 41 due due IN cord-265799-qda5awuc 24 42 to to IN cord-265799-qda5awuc 24 43 demand demand VB cord-265799-qda5awuc 24 44 ischemia ischemia NN cord-265799-qda5awuc 24 45 . . . cord-265799-qda5awuc 25 1 On on IN cord-265799-qda5awuc 25 2 day day NN cord-265799-qda5awuc 25 3 4 4 CD cord-265799-qda5awuc 25 4 of of IN cord-265799-qda5awuc 25 5 admission admission NN cord-265799-qda5awuc 25 6 , , , cord-265799-qda5awuc 25 7 the the DT cord-265799-qda5awuc 25 8 patient patient NN cord-265799-qda5awuc 25 9 was be VBD cord-265799-qda5awuc 25 10 taken take VBN cord-265799-qda5awuc 25 11 for for IN cord-265799-qda5awuc 25 12 cardiac cardiac JJ cord-265799-qda5awuc 25 13 catheterization catheterization NN cord-265799-qda5awuc 25 14 and and CC cord-265799-qda5awuc 25 15 was be VBD cord-265799-qda5awuc 25 16 found find VBN cord-265799-qda5awuc 25 17 to to TO cord-265799-qda5awuc 25 18 have have VB cord-265799-qda5awuc 25 19 severe severe JJ cord-265799-qda5awuc 25 20 multivessel multivessel JJ cord-265799-qda5awuc 25 21 coronary coronary JJ cord-265799-qda5awuc 25 22 artery artery NN cord-265799-qda5awuc 25 23 disease disease NN cord-265799-qda5awuc 25 24 ( ( -LRB- cord-265799-qda5awuc 25 25 CAD CAD NNP cord-265799-qda5awuc 25 26 ) ) -RRB- cord-265799-qda5awuc 25 27 , , , cord-265799-qda5awuc 25 28 and and CC cord-265799-qda5awuc 25 29 the the DT cord-265799-qda5awuc 25 30 patient patient NN cord-265799-qda5awuc 25 31 was be VBD cord-265799-qda5awuc 25 32 transferred transfer VBN cord-265799-qda5awuc 25 33 to to IN cord-265799-qda5awuc 25 34 our -PRON- PRP$ cord-265799-qda5awuc 25 35 hospital hospital NN cord-265799-qda5awuc 25 36 for for IN cord-265799-qda5awuc 25 37 coronary coronary JJ cord-265799-qda5awuc 25 38 artery artery NN cord-265799-qda5awuc 25 39 bypass bypass NN cord-265799-qda5awuc 25 40 grafting grafting NN cord-265799-qda5awuc 25 41 ( ( -LRB- cord-265799-qda5awuc 25 42 CABG CABG NNP cord-265799-qda5awuc 25 43 ) ) -RRB- cord-265799-qda5awuc 25 44 . . . cord-265799-qda5awuc 26 1 By by IN cord-265799-qda5awuc 26 2 day day NN cord-265799-qda5awuc 26 3 4 4 CD cord-265799-qda5awuc 26 4 , , , cord-265799-qda5awuc 26 5 the the DT cord-265799-qda5awuc 26 6 patient patient NN cord-265799-qda5awuc 26 7 had have VBD cord-265799-qda5awuc 26 8 been be VBN cord-265799-qda5awuc 26 9 completely completely RB cord-265799-qda5awuc 26 10 weaned wean VBN cord-265799-qda5awuc 26 11 from from IN cord-265799-qda5awuc 26 12 supplemental supplemental JJ cord-265799-qda5awuc 26 13 oxygen oxygen NN cord-265799-qda5awuc 26 14 . . . cord-265799-qda5awuc 27 1 On on IN cord-265799-qda5awuc 27 2 hospital hospital NN cord-265799-qda5awuc 27 3 day day NN cord-265799-qda5awuc 27 4 6 6 CD cord-265799-qda5awuc 27 5 , , , cord-265799-qda5awuc 27 6 the the DT cord-265799-qda5awuc 27 7 patient patient NN cord-265799-qda5awuc 27 8 was be VBD cord-265799-qda5awuc 27 9 taken take VBN cord-265799-qda5awuc 27 10 to to IN cord-265799-qda5awuc 27 11 the the DT cord-265799-qda5awuc 27 12 operating operating NN cord-265799-qda5awuc 27 13 room room NN cord-265799-qda5awuc 27 14 for for IN cord-265799-qda5awuc 27 15 a a DT cord-265799-qda5awuc 27 16 planned plan VBN cord-265799-qda5awuc 27 17 CABG CABG NNP cord-265799-qda5awuc 27 18 . . . cord-265799-qda5awuc 28 1 Another another DT cord-265799-qda5awuc 28 2 COVID-19 COVID-19 NNP cord-265799-qda5awuc 28 3 RT RT NNP cord-265799-qda5awuc 28 4 - - HYPH cord-265799-qda5awuc 28 5 PCR PCR NNP cord-265799-qda5awuc 28 6 was be VBD cord-265799-qda5awuc 28 7 sent send VBN cord-265799-qda5awuc 28 8 prior prior RB cord-265799-qda5awuc 28 9 to to IN cord-265799-qda5awuc 28 10 the the DT cord-265799-qda5awuc 28 11 OR OR NNP cord-265799-qda5awuc 28 12 and and CC cord-265799-qda5awuc 28 13 was be VBD cord-265799-qda5awuc 28 14 subsequently subsequently RB cord-265799-qda5awuc 28 15 reported report VBN cord-265799-qda5awuc 28 16 as as IN cord-265799-qda5awuc 28 17 positive positive JJ cord-265799-qda5awuc 28 18 after after IN cord-265799-qda5awuc 28 19 induction induction NN cord-265799-qda5awuc 28 20 of of IN cord-265799-qda5awuc 28 21 anesthesia anesthesia NN cord-265799-qda5awuc 28 22 . . . cord-265799-qda5awuc 29 1 It -PRON- PRP cord-265799-qda5awuc 29 2 was be VBD cord-265799-qda5awuc 29 3 determined determine VBN cord-265799-qda5awuc 29 4 that that IN cord-265799-qda5awuc 29 5 the the DT cord-265799-qda5awuc 29 6 patient patient NN cord-265799-qda5awuc 29 7 's 's POS cord-265799-qda5awuc 29 8 CAD CAD NNP cord-265799-qda5awuc 29 9 was be VBD cord-265799-qda5awuc 29 10 critical critical JJ cord-265799-qda5awuc 29 11 enough enough RB cord-265799-qda5awuc 29 12 to to TO cord-265799-qda5awuc 29 13 proceed proceed VB cord-265799-qda5awuc 29 14 with with IN cord-265799-qda5awuc 29 15 the the DT cord-265799-qda5awuc 29 16 revascularization revascularization NN cord-265799-qda5awuc 29 17 , , , cord-265799-qda5awuc 29 18 and and CC cord-265799-qda5awuc 29 19 the the DT cord-265799-qda5awuc 29 20 patient patient NN cord-265799-qda5awuc 29 21 underwent undergo VBD cord-265799-qda5awuc 29 22 a a DT cord-265799-qda5awuc 29 23 successful successful JJ cord-265799-qda5awuc 29 24 4-vessel 4-vessel CD cord-265799-qda5awuc 29 25 CABG CABG NNP cord-265799-qda5awuc 29 26 . . . cord-265799-qda5awuc 30 1 After after IN cord-265799-qda5awuc 30 2 the the DT cord-265799-qda5awuc 30 3 operation operation NN cord-265799-qda5awuc 30 4 , , , cord-265799-qda5awuc 30 5 the the DT cord-265799-qda5awuc 30 6 patient patient NN cord-265799-qda5awuc 30 7 was be VBD cord-265799-qda5awuc 30 8 admitted admit VBN cord-265799-qda5awuc 30 9 to to IN cord-265799-qda5awuc 30 10 the the DT cord-265799-qda5awuc 30 11 COVID-19 COVID-19 NNP cord-265799-qda5awuc 30 12 intensive intensive JJ cord-265799-qda5awuc 30 13 care care NN cord-265799-qda5awuc 30 14 unit unit NN cord-265799-qda5awuc 30 15 ( ( -LRB- cord-265799-qda5awuc 30 16 ICU ICU NNP cord-265799-qda5awuc 30 17 ) ) -RRB- cord-265799-qda5awuc 30 18 where where WRB cord-265799-qda5awuc 30 19 she -PRON- PRP cord-265799-qda5awuc 30 20 was be VBD cord-265799-qda5awuc 30 21 extubated extubate VBN cord-265799-qda5awuc 30 22 to to IN cord-265799-qda5awuc 30 23 4 4 CD cord-265799-qda5awuc 30 24 liters liter NNS cord-265799-qda5awuc 30 25 nasal nasal NN cord-265799-qda5awuc 30 26 cannula cannula NN cord-265799-qda5awuc 30 27 without without IN cord-265799-qda5awuc 30 28 incident incident NN cord-265799-qda5awuc 30 29 on on IN cord-265799-qda5awuc 30 30 day day NN cord-265799-qda5awuc 30 31 7 7 CD cord-265799-qda5awuc 30 32 ( ( -LRB- cord-265799-qda5awuc 30 33 postoperative postoperative JJ cord-265799-qda5awuc 30 34 day day NN cord-265799-qda5awuc 30 35 1 1 CD cord-265799-qda5awuc 30 36 ) ) -RRB- cord-265799-qda5awuc 30 37 . . . cord-265799-qda5awuc 31 1 The the DT cord-265799-qda5awuc 31 2 patient patient NN cord-265799-qda5awuc 31 3 's 's POS cord-265799-qda5awuc 31 4 oxygen oxygen NN cord-265799-qda5awuc 31 5 requirements requirement NNS cord-265799-qda5awuc 31 6 increased increase VBN cord-265799-qda5awuc 31 7 by by IN cord-265799-qda5awuc 31 8 day day NN cord-265799-qda5awuc 31 9 8 8 CD cord-265799-qda5awuc 31 10 to to TO cord-265799-qda5awuc 31 11 8 8 CD cord-265799-qda5awuc 31 12 liters liter NNS cord-265799-qda5awuc 31 13 nasal nasal NN cord-265799-qda5awuc 31 14 cannula cannula NN cord-265799-qda5awuc 31 15 and and CC cord-265799-qda5awuc 31 16 she -PRON- PRP cord-265799-qda5awuc 31 17 developed develop VBD cord-265799-qda5awuc 31 18 a a DT cord-265799-qda5awuc 31 19 new new JJ cord-265799-qda5awuc 31 20 cough cough NN cord-265799-qda5awuc 31 21 and and CC cord-265799-qda5awuc 31 22 worsening worsen VBG cord-265799-qda5awuc 31 23 infiltrates infiltrate NNS cord-265799-qda5awuc 31 24 on on IN cord-265799-qda5awuc 31 25 chest chest NN cord-265799-qda5awuc 31 26 Xray Xray NNP cord-265799-qda5awuc 31 27 . . . cord-265799-qda5awuc 32 1 A a DT cord-265799-qda5awuc 32 2 loading loading NN cord-265799-qda5awuc 32 3 dose dose NN cord-265799-qda5awuc 32 4 of of IN cord-265799-qda5awuc 32 5 remdesivir remdesivir NNP cord-265799-qda5awuc 32 6 200 200 CD cord-265799-qda5awuc 32 7 mg mg NNP cord-265799-qda5awuc 32 8 intravenous intravenous JJ cord-265799-qda5awuc 32 9 ( ( -LRB- cord-265799-qda5awuc 32 10 IV IV NNP cord-265799-qda5awuc 32 11 ) ) -RRB- cord-265799-qda5awuc 32 12 was be VBD cord-265799-qda5awuc 32 13 administered administer VBN cord-265799-qda5awuc 32 14 the the DT cord-265799-qda5awuc 32 15 same same JJ cord-265799-qda5awuc 32 16 day day NN cord-265799-qda5awuc 32 17 due due JJ cord-265799-qda5awuc 32 18 to to IN cord-265799-qda5awuc 32 19 worsening worsen VBG cord-265799-qda5awuc 32 20 COVID-19 covid-19 JJ cord-265799-qda5awuc 32 21 pneumonia pneumonia NN cord-265799-qda5awuc 32 22 , , , cord-265799-qda5awuc 32 23 and and CC cord-265799-qda5awuc 32 24 a a DT cord-265799-qda5awuc 32 25 maintenance maintenance NN cord-265799-qda5awuc 32 26 of of IN cord-265799-qda5awuc 32 27 remdesivir remdesivir NNP cord-265799-qda5awuc 32 28 100 100 CD cord-265799-qda5awuc 32 29 mg mg NNP cord-265799-qda5awuc 32 30 Accepted Accepted NNP cord-265799-qda5awuc 32 31 Article Article NNP cord-265799-qda5awuc 32 32 IV IV NNP cord-265799-qda5awuc 33 1 every every DT cord-265799-qda5awuc 33 2 24 24 CD cord-265799-qda5awuc 33 3 hours hour NNS cord-265799-qda5awuc 33 4 was be VBD cord-265799-qda5awuc 33 5 started start VBN cord-265799-qda5awuc 33 6 on on IN cord-265799-qda5awuc 33 7 day day NN cord-265799-qda5awuc 33 8 9 9 CD cord-265799-qda5awuc 33 9 for for IN cord-265799-qda5awuc 33 10 a a DT cord-265799-qda5awuc 33 11 planned planned JJ cord-265799-qda5awuc 33 12 total total NN cord-265799-qda5awuc 33 13 of of IN cord-265799-qda5awuc 33 14 5 5 CD cord-265799-qda5awuc 33 15 days day NNS cord-265799-qda5awuc 33 16 of of IN cord-265799-qda5awuc 33 17 therapy therapy NN cord-265799-qda5awuc 33 18 . . . cord-265799-qda5awuc 34 1 Prior prior RB cord-265799-qda5awuc 34 2 to to IN cord-265799-qda5awuc 34 3 remdesivir remdesivir NNP cord-265799-qda5awuc 34 4 administration administration NNP cord-265799-qda5awuc 34 5 , , , cord-265799-qda5awuc 34 6 the the DT cord-265799-qda5awuc 34 7 patient patient NN cord-265799-qda5awuc 34 8 's 's POS cord-265799-qda5awuc 34 9 liver liver NN cord-265799-qda5awuc 34 10 function function NN cord-265799-qda5awuc 34 11 enzymes enzyme NNS cord-265799-qda5awuc 34 12 were be VBD cord-265799-qda5awuc 34 13 within within IN cord-265799-qda5awuc 34 14 normal normal JJ cord-265799-qda5awuc 34 15 limits limit NNS cord-265799-qda5awuc 34 16 . . . cord-265799-qda5awuc 35 1 On on IN cord-265799-qda5awuc 35 2 day day NN cord-265799-qda5awuc 35 3 10 10 CD cord-265799-qda5awuc 35 4 , , , cord-265799-qda5awuc 35 5 the the DT cord-265799-qda5awuc 35 6 patient patient NN cord-265799-qda5awuc 35 7 was be VBD cord-265799-qda5awuc 35 8 transferred transfer VBN cord-265799-qda5awuc 35 9 to to IN cord-265799-qda5awuc 35 10 the the DT cord-265799-qda5awuc 35 11 ICU ICU NNP cord-265799-qda5awuc 35 12 for for IN cord-265799-qda5awuc 35 13 increasing increase VBG cord-265799-qda5awuc 35 14 oxygen oxygen NN cord-265799-qda5awuc 35 15 demands demand NNS cord-265799-qda5awuc 35 16 and and CC cord-265799-qda5awuc 35 17 an an DT cord-265799-qda5awuc 35 18 amiodarone amiodarone NN cord-265799-qda5awuc 35 19 infusion infusion NN cord-265799-qda5awuc 35 20 was be VBD cord-265799-qda5awuc 35 21 initiated initiate VBN cord-265799-qda5awuc 35 22 for for IN cord-265799-qda5awuc 35 23 newonset newonset NNP cord-265799-qda5awuc 35 24 , , , cord-265799-qda5awuc 35 25 post post JJ cord-265799-qda5awuc 35 26 - - JJ cord-265799-qda5awuc 35 27 operative operative JJ cord-265799-qda5awuc 35 28 atrial atrial JJ cord-265799-qda5awuc 35 29 fibrillation fibrillation NN cord-265799-qda5awuc 35 30 . . . cord-265799-qda5awuc 36 1 The the DT cord-265799-qda5awuc 36 2 amiodarone amiodarone NN cord-265799-qda5awuc 36 3 was be VBD cord-265799-qda5awuc 36 4 initiated initiate VBN cord-265799-qda5awuc 36 5 with with IN cord-265799-qda5awuc 36 6 a a DT cord-265799-qda5awuc 36 7 150 150 CD cord-265799-qda5awuc 36 8 mg mg NNP cord-265799-qda5awuc 36 9 IV IV NNP cord-265799-qda5awuc 36 10 loading loading NN cord-265799-qda5awuc 36 11 dose dose NN cord-265799-qda5awuc 36 12 over over IN cord-265799-qda5awuc 36 13 10 10 CD cord-265799-qda5awuc 36 14 minutes minute NNS cord-265799-qda5awuc 36 15 , , , cord-265799-qda5awuc 36 16 and and CC cord-265799-qda5awuc 36 17 the the DT cord-265799-qda5awuc 36 18 continuous continuous JJ cord-265799-qda5awuc 36 19 infusion infusion NN cord-265799-qda5awuc 36 20 ( ( -LRB- cord-265799-qda5awuc 36 21 450 450 CD cord-265799-qda5awuc 36 22 mg/250 mg/250 JJ cord-265799-qda5awuc 36 23 mL mL NNP cord-265799-qda5awuc 36 24 ) ) -RRB- cord-265799-qda5awuc 36 25 was be VBD cord-265799-qda5awuc 36 26 started start VBN cord-265799-qda5awuc 36 27 at at IN cord-265799-qda5awuc 36 28 1 1 CD cord-265799-qda5awuc 36 29 mg mg NNP cord-265799-qda5awuc 36 30 / / SYM cord-265799-qda5awuc 36 31 min min NN cord-265799-qda5awuc 36 32 for for IN cord-265799-qda5awuc 36 33 6 6 CD cord-265799-qda5awuc 36 34 hours hour NNS cord-265799-qda5awuc 36 35 followed follow VBN cord-265799-qda5awuc 36 36 by by IN cord-265799-qda5awuc 36 37 0.5 0.5 CD cord-265799-qda5awuc 36 38 mg mg NNP cord-265799-qda5awuc 36 39 / / SYM cord-265799-qda5awuc 36 40 min min NN cord-265799-qda5awuc 36 41 . . . cord-265799-qda5awuc 37 1 By by IN cord-265799-qda5awuc 37 2 day day NN cord-265799-qda5awuc 37 3 10 10 CD cord-265799-qda5awuc 37 4 , , , cord-265799-qda5awuc 37 5 the the DT cord-265799-qda5awuc 37 6 patient patient NN cord-265799-qda5awuc 37 7 was be VBD cord-265799-qda5awuc 37 8 requiring require VBG cord-265799-qda5awuc 37 9 humidified humidify VBN cord-265799-qda5awuc 37 10 , , , cord-265799-qda5awuc 37 11 high high JJ cord-265799-qda5awuc 37 12 flow flow NN cord-265799-qda5awuc 37 13 nasal nasal NN cord-265799-qda5awuc 37 14 cannula cannula NN cord-265799-qda5awuc 37 15 at at IN cord-265799-qda5awuc 37 16 60 60 CD cord-265799-qda5awuc 37 17 liters liter NNS cord-265799-qda5awuc 37 18 / / SYM cord-265799-qda5awuc 37 19 minute minute NN cord-265799-qda5awuc 37 20 at at IN cord-265799-qda5awuc 37 21 100 100 CD cord-265799-qda5awuc 37 22 % % NN cord-265799-qda5awuc 37 23 By by IN cord-265799-qda5awuc 37 24 the the DT cord-265799-qda5awuc 37 25 end end NN cord-265799-qda5awuc 37 26 of of IN cord-265799-qda5awuc 37 27 the the DT cord-265799-qda5awuc 37 28 21-hour 21-hour JJ cord-265799-qda5awuc 37 29 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 37 30 protocol protocol NN cord-265799-qda5awuc 37 31 , , , cord-265799-qda5awuc 37 32 the the DT cord-265799-qda5awuc 37 33 patient patient NN cord-265799-qda5awuc 37 34 's 's POS cord-265799-qda5awuc 37 35 AST AST NNP cord-265799-qda5awuc 37 36 and and CC cord-265799-qda5awuc 37 37 ALT ALT NNP cord-265799-qda5awuc 37 38 had have VBD cord-265799-qda5awuc 37 39 decreased decrease VBN cord-265799-qda5awuc 37 40 to to IN cord-265799-qda5awuc 37 41 1348 1348 CD cord-265799-qda5awuc 37 42 and and CC cord-265799-qda5awuc 37 43 1861 1861 CD cord-265799-qda5awuc 37 44 units unit NNS cord-265799-qda5awuc 37 45 / / SYM cord-265799-qda5awuc 37 46 L L NNP cord-265799-qda5awuc 37 47 , , , cord-265799-qda5awuc 37 48 respectively respectively RB cord-265799-qda5awuc 37 49 . . . cord-265799-qda5awuc 38 1 By by IN cord-265799-qda5awuc 38 2 day day NN cord-265799-qda5awuc 38 3 14 14 CD cord-265799-qda5awuc 38 4 , , , cord-265799-qda5awuc 38 5 the the DT cord-265799-qda5awuc 38 6 AST AST NNP cord-265799-qda5awuc 38 7 and and CC cord-265799-qda5awuc 38 8 ALT ALT NNP cord-265799-qda5awuc 38 9 had have VBD cord-265799-qda5awuc 38 10 decreased decrease VBN cord-265799-qda5awuc 38 11 to to IN cord-265799-qda5awuc 38 12 235 235 CD cord-265799-qda5awuc 38 13 and and CC cord-265799-qda5awuc 38 14 966 966 CD cord-265799-qda5awuc 38 15 units unit NNS cord-265799-qda5awuc 38 16 / / SYM cord-265799-qda5awuc 38 17 L L NNP cord-265799-qda5awuc 38 18 , , , cord-265799-qda5awuc 38 19 respectively respectively RB cord-265799-qda5awuc 38 20 , , , cord-265799-qda5awuc 38 21 along along IN cord-265799-qda5awuc 38 22 with with IN cord-265799-qda5awuc 38 23 a a DT cord-265799-qda5awuc 38 24 total total JJ cord-265799-qda5awuc 38 25 bilirubin bilirubin NN cord-265799-qda5awuc 38 26 of of IN cord-265799-qda5awuc 38 27 2.1 2.1 CD cord-265799-qda5awuc 38 28 mg mg NNP cord-265799-qda5awuc 38 29 / / SYM cord-265799-qda5awuc 38 30 dL dl NN cord-265799-qda5awuc 38 31 and and CC cord-265799-qda5awuc 38 32 an an DT cord-265799-qda5awuc 38 33 ammonia ammonia NN cord-265799-qda5awuc 38 34 of of IN cord-265799-qda5awuc 38 35 69 69 CD cord-265799-qda5awuc 38 36 umol umol JJ cord-265799-qda5awuc 38 37 / / SYM cord-265799-qda5awuc 38 38 L. L. NNP cord-265799-qda5awuc 39 1 Over over IN cord-265799-qda5awuc 39 2 the the DT cord-265799-qda5awuc 39 3 course course NN cord-265799-qda5awuc 39 4 of of IN cord-265799-qda5awuc 39 5 the the DT cord-265799-qda5awuc 39 6 rest rest NN cord-265799-qda5awuc 39 7 of of IN cord-265799-qda5awuc 39 8 her -PRON- PRP$ cord-265799-qda5awuc 39 9 hospital hospital NN cord-265799-qda5awuc 39 10 stay stay NN cord-265799-qda5awuc 39 11 , , , cord-265799-qda5awuc 39 12 the the DT cord-265799-qda5awuc 39 13 patient patient NN cord-265799-qda5awuc 39 14 's 's POS cord-265799-qda5awuc 39 15 oxygen oxygen NN cord-265799-qda5awuc 39 16 requirements requirement NNS cord-265799-qda5awuc 39 17 improved improve VBN cord-265799-qda5awuc 39 18 until until IN cord-265799-qda5awuc 39 19 she -PRON- PRP cord-265799-qda5awuc 39 20 was be VBD cord-265799-qda5awuc 39 21 weaned wean VBN cord-265799-qda5awuc 39 22 to to TO cord-265799-qda5awuc 39 23 room room NN cord-265799-qda5awuc 39 24 air air NN cord-265799-qda5awuc 39 25 on on IN cord-265799-qda5awuc 39 26 day day NN cord-265799-qda5awuc 39 27 20 20 CD cord-265799-qda5awuc 39 28 and and CC cord-265799-qda5awuc 39 29 her -PRON- PRP$ cord-265799-qda5awuc 39 30 LFTs lft NNS cord-265799-qda5awuc 39 31 , , , cord-265799-qda5awuc 39 32 total total JJ cord-265799-qda5awuc 39 33 bilirubin bilirubin NN cord-265799-qda5awuc 39 34 , , , cord-265799-qda5awuc 39 35 and and CC cord-265799-qda5awuc 39 36 INR INR NNP cord-265799-qda5awuc 39 37 returned return VBD cord-265799-qda5awuc 39 38 to to IN cord-265799-qda5awuc 39 39 within within IN cord-265799-qda5awuc 39 40 normal normal JJ cord-265799-qda5awuc 39 41 limits limit NNS cord-265799-qda5awuc 39 42 by by IN cord-265799-qda5awuc 39 43 day day NN cord-265799-qda5awuc 39 44 24 24 CD cord-265799-qda5awuc 39 45 of of IN cord-265799-qda5awuc 39 46 hospitalization hospitalization NN cord-265799-qda5awuc 39 47 . . . cord-265799-qda5awuc 40 1 The the DT cord-265799-qda5awuc 40 2 patient patient NN cord-265799-qda5awuc 40 3 was be VBD cord-265799-qda5awuc 40 4 then then RB cord-265799-qda5awuc 40 5 discharged discharge VBN cord-265799-qda5awuc 40 6 to to IN cord-265799-qda5awuc 40 7 home home NN cord-265799-qda5awuc 40 8 with with IN cord-265799-qda5awuc 40 9 home home NN cord-265799-qda5awuc 40 10 health health NN cord-265799-qda5awuc 40 11 . . . cord-265799-qda5awuc 41 1 Case case NN cord-265799-qda5awuc 41 2 # # $ cord-265799-qda5awuc 41 3 2 2 CD cord-265799-qda5awuc 41 4 : : : cord-265799-qda5awuc 42 1 An an DT cord-265799-qda5awuc 42 2 80-year 80-year JJ cord-265799-qda5awuc 42 3 - - HYPH cord-265799-qda5awuc 42 4 old old JJ cord-265799-qda5awuc 42 5 female female NN cord-265799-qda5awuc 42 6 with with IN cord-265799-qda5awuc 42 7 a a DT cord-265799-qda5awuc 42 8 history history NN cord-265799-qda5awuc 42 9 of of IN cord-265799-qda5awuc 42 10 hypertension hypertension NN cord-265799-qda5awuc 42 11 , , , cord-265799-qda5awuc 42 12 diabetes diabetes NN cord-265799-qda5awuc 42 13 mellitus mellitus NN cord-265799-qda5awuc 42 14 , , , cord-265799-qda5awuc 42 15 and and CC cord-265799-qda5awuc 42 16 hyperlipidemia hyperlipidemia NN cord-265799-qda5awuc 42 17 presented present VBN cord-265799-qda5awuc 42 18 to to IN cord-265799-qda5awuc 42 19 the the DT cord-265799-qda5awuc 42 20 emergency emergency NN cord-265799-qda5awuc 42 21 department department NN cord-265799-qda5awuc 42 22 with with IN cord-265799-qda5awuc 42 23 low low JJ cord-265799-qda5awuc 42 24 back back JJ cord-265799-qda5awuc 42 25 pain pain NN cord-265799-qda5awuc 42 26 , , , cord-265799-qda5awuc 42 27 fatigue fatigue NN cord-265799-qda5awuc 42 28 , , , cord-265799-qda5awuc 42 29 shortness shortness NN cord-265799-qda5awuc 42 30 of of IN cord-265799-qda5awuc 42 31 breath breath NN cord-265799-qda5awuc 42 32 , , , cord-265799-qda5awuc 42 33 and and CC cord-265799-qda5awuc 42 34 difficulty difficulty NN cord-265799-qda5awuc 42 35 with with IN cord-265799-qda5awuc 42 36 urination urination NN cord-265799-qda5awuc 42 37 . . . cord-265799-qda5awuc 43 1 She -PRON- PRP cord-265799-qda5awuc 43 2 endorsed endorse VBD cord-265799-qda5awuc 43 3 fever fever NN cord-265799-qda5awuc 43 4 and and CC cord-265799-qda5awuc 43 5 chills chill NNS cord-265799-qda5awuc 43 6 but but CC cord-265799-qda5awuc 43 7 no no DT cord-265799-qda5awuc 43 8 sick sick JJ cord-265799-qda5awuc 43 9 contacts contact NNS cord-265799-qda5awuc 43 10 or or CC cord-265799-qda5awuc 43 11 recent recent JJ cord-265799-qda5awuc 43 12 travel travel NN cord-265799-qda5awuc 43 13 . . . cord-265799-qda5awuc 44 1 Five five CD cord-265799-qda5awuc 44 2 days day NNS cord-265799-qda5awuc 44 3 previously previously RB cord-265799-qda5awuc 44 4 , , , cord-265799-qda5awuc 44 5 the the DT cord-265799-qda5awuc 44 6 patient patient NN cord-265799-qda5awuc 44 7 had have VBD cord-265799-qda5awuc 44 8 been be VBN cord-265799-qda5awuc 44 9 admitted admit VBN cord-265799-qda5awuc 44 10 to to IN cord-265799-qda5awuc 44 11 our -PRON- PRP$ cord-265799-qda5awuc 44 12 institution institution NN cord-265799-qda5awuc 44 13 for for IN cord-265799-qda5awuc 44 14 atypical atypical JJ cord-265799-qda5awuc 44 15 chest chest NN cord-265799-qda5awuc 44 16 pain pain NN cord-265799-qda5awuc 44 17 and and CC cord-265799-qda5awuc 44 18 was be VBD cord-265799-qda5awuc 44 19 found find VBN cord-265799-qda5awuc 44 20 to to TO cord-265799-qda5awuc 44 21 have have VB cord-265799-qda5awuc 44 22 COVID-19 COVID-19 NNP cord-265799-qda5awuc 44 23 pneumonia pneumonia NN cord-265799-qda5awuc 44 24 confirmed confirm VBN cord-265799-qda5awuc 44 25 by by IN cord-265799-qda5awuc 44 26 RT RT NNP cord-265799-qda5awuc 44 27 - - HYPH cord-265799-qda5awuc 44 28 PCR PCR NNP cord-265799-qda5awuc 44 29 , , , cord-265799-qda5awuc 44 30 and and CC cord-265799-qda5awuc 44 31 the the DT cord-265799-qda5awuc 44 32 patient patient NN cord-265799-qda5awuc 44 33 was be VBD cord-265799-qda5awuc 44 34 subsequently subsequently RB cord-265799-qda5awuc 44 35 discharged discharge VBN cord-265799-qda5awuc 44 36 the the DT cord-265799-qda5awuc 44 37 next next JJ cord-265799-qda5awuc 44 38 day day NN cord-265799-qda5awuc 44 39 . . . cord-265799-qda5awuc 45 1 Upon upon IN cord-265799-qda5awuc 45 2 this this DT cord-265799-qda5awuc 45 3 current current JJ cord-265799-qda5awuc 45 4 admission admission NN cord-265799-qda5awuc 45 5 , , , cord-265799-qda5awuc 45 6 the the DT cord-265799-qda5awuc 45 7 patient patient NN cord-265799-qda5awuc 45 8 's 's POS cord-265799-qda5awuc 45 9 chest chest NN cord-265799-qda5awuc 45 10 Xray Xray NNP cord-265799-qda5awuc 45 11 showed show VBD cord-265799-qda5awuc 45 12 persistent persistent JJ cord-265799-qda5awuc 45 13 bibasilar bibasilar NNP cord-265799-qda5awuc 45 14 and and CC cord-265799-qda5awuc 45 15 left leave VBD cord-265799-qda5awuc 45 16 perihilar perihilar NNP cord-265799-qda5awuc 45 17 infiltrates infiltrate VBZ cord-265799-qda5awuc 45 18 . . . cord-265799-qda5awuc 46 1 She -PRON- PRP cord-265799-qda5awuc 46 2 was be VBD cord-265799-qda5awuc 46 3 found find VBN cord-265799-qda5awuc 46 4 to to TO cord-265799-qda5awuc 46 5 have have VB cord-265799-qda5awuc 46 6 an an DT cord-265799-qda5awuc 46 7 oxygen oxygen NN cord-265799-qda5awuc 46 8 saturation saturation NN cord-265799-qda5awuc 46 9 of of IN cord-265799-qda5awuc 46 10 82 82 CD cord-265799-qda5awuc 46 11 % % NN cord-265799-qda5awuc 46 12 on on IN cord-265799-qda5awuc 46 13 room room NN cord-265799-qda5awuc 46 14 air air NN cord-265799-qda5awuc 46 15 , , , cord-265799-qda5awuc 46 16 initiated initiate VBN cord-265799-qda5awuc 46 17 on on IN cord-265799-qda5awuc 46 18 supplemental supplemental JJ cord-265799-qda5awuc 46 19 oxygen oxygen NN cord-265799-qda5awuc 46 20 of of IN cord-265799-qda5awuc 46 21 15 15 CD cord-265799-qda5awuc 46 22 L l NN cord-265799-qda5awuc 46 23 / / SYM cord-265799-qda5awuc 46 24 minute minute NN cord-265799-qda5awuc 46 25 , , , cord-265799-qda5awuc 46 26 admitted admit VBN cord-265799-qda5awuc 46 27 to to IN cord-265799-qda5awuc 46 28 a a DT cord-265799-qda5awuc 46 29 step step NN cord-265799-qda5awuc 46 30 - - HYPH cord-265799-qda5awuc 46 31 down down RP cord-265799-qda5awuc 46 32 COVID covid JJ cord-265799-qda5awuc 46 33 unit unit NN cord-265799-qda5awuc 46 34 , , , cord-265799-qda5awuc 46 35 and and CC cord-265799-qda5awuc 46 36 started start VBD cord-265799-qda5awuc 46 37 on on IN cord-265799-qda5awuc 46 38 dexamethasone dexamethasone NNP cord-265799-qda5awuc 46 39 6 6 CD cord-265799-qda5awuc 46 40 mg mg NNS cord-265799-qda5awuc 46 41 orally orally RB cord-265799-qda5awuc 46 42 every every DT cord-265799-qda5awuc 46 43 day day NN cord-265799-qda5awuc 46 44 . . . cord-265799-qda5awuc 47 1 By by IN cord-265799-qda5awuc 47 2 day day NN cord-265799-qda5awuc 47 3 on on IN cord-265799-qda5awuc 47 4 remdesivir remdesivir NNP cord-265799-qda5awuc 47 5 , , , cord-265799-qda5awuc 47 6 with with IN cord-265799-qda5awuc 47 7 a a DT cord-265799-qda5awuc 47 8 200 200 CD cord-265799-qda5awuc 47 9 mg mg NNP cord-265799-qda5awuc 47 10 IV IV NNP cord-265799-qda5awuc 47 11 loading loading NN cord-265799-qda5awuc 47 12 dose dose NN cord-265799-qda5awuc 47 13 and and CC cord-265799-qda5awuc 47 14 100 100 CD cord-265799-qda5awuc 47 15 mg mg NNP cord-265799-qda5awuc 47 16 IV IV NNP cord-265799-qda5awuc 47 17 daily daily RB cord-265799-qda5awuc 47 18 for for IN cord-265799-qda5awuc 47 19 the the DT cord-265799-qda5awuc 47 20 next next JJ cord-265799-qda5awuc 47 21 4 4 CD cord-265799-qda5awuc 47 22 days day NNS cord-265799-qda5awuc 47 23 ( ( -LRB- cord-265799-qda5awuc 47 24 finishing finish VBG cord-265799-qda5awuc 47 25 on on IN cord-265799-qda5awuc 47 26 hospital hospital NN cord-265799-qda5awuc 47 27 day day NN cord-265799-qda5awuc 47 28 9 9 CD cord-265799-qda5awuc 47 29 ) ) -RRB- cord-265799-qda5awuc 47 30 . . . cord-265799-qda5awuc 48 1 She -PRON- PRP cord-265799-qda5awuc 48 2 was be VBD cord-265799-qda5awuc 48 3 also also RB cord-265799-qda5awuc 48 4 consented consent VBN cord-265799-qda5awuc 48 5 for for IN cord-265799-qda5awuc 48 6 convalescent convalescent JJ cord-265799-qda5awuc 48 7 plasma plasma NN cord-265799-qda5awuc 48 8 , , , cord-265799-qda5awuc 48 9 which which WDT cord-265799-qda5awuc 48 10 was be VBD cord-265799-qda5awuc 48 11 administered administer VBN cord-265799-qda5awuc 48 12 on on IN cord-265799-qda5awuc 48 13 day day NN cord-265799-qda5awuc 48 14 7 7 CD cord-265799-qda5awuc 48 15 . . . cord-265799-qda5awuc 49 1 While while IN cord-265799-qda5awuc 49 2 receiving receive VBG cord-265799-qda5awuc 49 3 remdesivir remdesivir NNP cord-265799-qda5awuc 49 4 , , , cord-265799-qda5awuc 49 5 her -PRON- PRP$ cord-265799-qda5awuc 49 6 transaminases transaminase NNS cord-265799-qda5awuc 49 7 remained remain VBD cord-265799-qda5awuc 49 8 stable stable JJ cord-265799-qda5awuc 49 9 and and CC cord-265799-qda5awuc 49 10 within within IN cord-265799-qda5awuc 49 11 normal normal JJ cord-265799-qda5awuc 49 12 limits limit NNS cord-265799-qda5awuc 49 13 , , , cord-265799-qda5awuc 49 14 however however RB cord-265799-qda5awuc 49 15 , , , cord-265799-qda5awuc 49 16 starting start VBG cord-265799-qda5awuc 49 17 on on IN cord-265799-qda5awuc 49 18 day day NN cord-265799-qda5awuc 49 19 5 5 CD cord-265799-qda5awuc 49 20 of of IN cord-265799-qda5awuc 49 21 remdesivir remdesivir NNP cord-265799-qda5awuc 49 22 therapy therapy NN cord-265799-qda5awuc 49 23 , , , cord-265799-qda5awuc 49 24 her -PRON- PRP$ cord-265799-qda5awuc 49 25 alkaline alkaline JJ cord-265799-qda5awuc 49 26 phosphatase phosphatase NN cord-265799-qda5awuc 49 27 began begin VBD cord-265799-qda5awuc 49 28 trending trend VBG cord-265799-qda5awuc 49 29 up up RP cord-265799-qda5awuc 49 30 ( ( -LRB- cord-265799-qda5awuc 49 31 but but CC cord-265799-qda5awuc 49 32 remaining remain VBG cord-265799-qda5awuc 49 33 within within IN cord-265799-qda5awuc 49 34 normal normal JJ cord-265799-qda5awuc 49 35 limits limit NNS cord-265799-qda5awuc 49 36 during during IN cord-265799-qda5awuc 49 37 therapy therapy NN cord-265799-qda5awuc 49 38 ) ) -RRB- cord-265799-qda5awuc 49 39 as as RB cord-265799-qda5awuc 49 40 well well RB cord-265799-qda5awuc 49 41 as as IN cord-265799-qda5awuc 49 42 her -PRON- PRP$ cord-265799-qda5awuc 49 43 total total JJ cord-265799-qda5awuc 49 44 bilirubin bilirubin NN cord-265799-qda5awuc 49 45 . . . cord-265799-qda5awuc 50 1 On on IN cord-265799-qda5awuc 50 2 day day NN cord-265799-qda5awuc 50 3 11 11 CD cord-265799-qda5awuc 50 4 , , , cord-265799-qda5awuc 50 5 the the DT cord-265799-qda5awuc 50 6 patient patient NN cord-265799-qda5awuc 50 7 's 's POS cord-265799-qda5awuc 50 8 oxygen oxygen NN cord-265799-qda5awuc 50 9 requirements requirement NNS cord-265799-qda5awuc 50 10 continued continue VBD cord-265799-qda5awuc 50 11 to to TO cord-265799-qda5awuc 50 12 escalate escalate VB cord-265799-qda5awuc 50 13 , , , cord-265799-qda5awuc 50 14 and and CC cord-265799-qda5awuc 50 15 she -PRON- PRP cord-265799-qda5awuc 50 16 was be VBD cord-265799-qda5awuc 50 17 admitted admit VBN cord-265799-qda5awuc 50 18 to to IN cord-265799-qda5awuc 50 19 the the DT cord-265799-qda5awuc 50 20 ICU ICU NNP cord-265799-qda5awuc 50 21 where where WRB cord-265799-qda5awuc 50 22 she -PRON- PRP cord-265799-qda5awuc 50 23 was be VBD cord-265799-qda5awuc 50 24 placed place VBN cord-265799-qda5awuc 50 25 on on IN cord-265799-qda5awuc 50 26 BiPAP BiPAP NNP cord-265799-qda5awuc 50 27 to to TO cord-265799-qda5awuc 50 28 maintain maintain VB cord-265799-qda5awuc 50 29 her -PRON- PRP$ cord-265799-qda5awuc 50 30 oxygen oxygen NN cord-265799-qda5awuc 50 31 saturation saturation NN cord-265799-qda5awuc 50 32 . . . cord-265799-qda5awuc 51 1 She -PRON- PRP cord-265799-qda5awuc 51 2 also also RB cord-265799-qda5awuc 51 3 required require VBD cord-265799-qda5awuc 51 4 norepinephrine norepinephrine NN cord-265799-qda5awuc 51 5 and and CC cord-265799-qda5awuc 51 6 vasopressin vasopressin NN cord-265799-qda5awuc 51 7 continuous continuous JJ cord-265799-qda5awuc 51 8 infusions infusion NNS cord-265799-qda5awuc 51 9 due due JJ cord-265799-qda5awuc 51 10 to to IN cord-265799-qda5awuc 51 11 suspected suspect VBN cord-265799-qda5awuc 51 12 distributive distributive JJ cord-265799-qda5awuc 51 13 / / SYM cord-265799-qda5awuc 51 14 septic septic JJ cord-265799-qda5awuc 51 15 shock shock NN cord-265799-qda5awuc 51 16 ( ( -LRB- cord-265799-qda5awuc 51 17 increasing increase VBG cord-265799-qda5awuc 51 18 to to IN cord-265799-qda5awuc 51 19 a a DT cord-265799-qda5awuc 51 20 maximum maximum JJ cord-265799-qda5awuc 51 21 norepinephrine norepinephrine NN cord-265799-qda5awuc 51 22 dose dose NN cord-265799-qda5awuc 51 23 of of IN cord-265799-qda5awuc 51 24 0.8 0.8 CD cord-265799-qda5awuc 51 25 mcg mcg NN cord-265799-qda5awuc 51 26 / / SYM cord-265799-qda5awuc 51 27 kg kg NNP cord-265799-qda5awuc 51 28 / / SYM cord-265799-qda5awuc 51 29 min min NN cord-265799-qda5awuc 51 30 for for IN cord-265799-qda5awuc 51 31 around around RB cord-265799-qda5awuc 51 32 1 1 CD cord-265799-qda5awuc 51 33 hour hour NN cord-265799-qda5awuc 51 34 on on IN cord-265799-qda5awuc 51 35 day day NN cord-265799-qda5awuc 51 36 13 13 CD cord-265799-qda5awuc 51 37 and and CC cord-265799-qda5awuc 51 38 then then RB cord-265799-qda5awuc 51 39 steadily steadily RB cord-265799-qda5awuc 51 40 weaned wean VBD cord-265799-qda5awuc 51 41 to to IN cord-265799-qda5awuc 51 42 < < XX cord-265799-qda5awuc 51 43 0.2 0.2 CD cord-265799-qda5awuc 51 44 mcg mcg NNS cord-265799-qda5awuc 51 45 / / SYM cord-265799-qda5awuc 51 46 kg kg NNP cord-265799-qda5awuc 51 47 / / SYM cord-265799-qda5awuc 51 48 hr hr NN cord-265799-qda5awuc 51 49 within within IN cord-265799-qda5awuc 51 50 24 24 CD cord-265799-qda5awuc 51 51 hours hour NNS cord-265799-qda5awuc 51 52 ) ) -RRB- cord-265799-qda5awuc 51 53 . . . cord-265799-qda5awuc 52 1 On on IN cord-265799-qda5awuc 52 2 day day NN cord-265799-qda5awuc 52 3 12 12 CD cord-265799-qda5awuc 52 4 the the DT cord-265799-qda5awuc 52 5 patient patient NN cord-265799-qda5awuc 52 6 was be VBD cord-265799-qda5awuc 52 7 given give VBN cord-265799-qda5awuc 52 8 tocilizumab tocilizumab NNP cord-265799-qda5awuc 52 9 640 640 CD cord-265799-qda5awuc 52 10 mg mg NN cord-265799-qda5awuc 52 11 ( ( -LRB- cord-265799-qda5awuc 52 12 settings setting NNS cord-265799-qda5awuc 52 13 were be VBD cord-265799-qda5awuc 52 14 able able JJ cord-265799-qda5awuc 52 15 to to TO cord-265799-qda5awuc 52 16 be be VB cord-265799-qda5awuc 52 17 weaned wean VBN cord-265799-qda5awuc 52 18 down down RP cord-265799-qda5awuc 52 19 from from IN cord-265799-qda5awuc 52 20 an an DT cord-265799-qda5awuc 52 21 FiO2 FiO2 NNS cord-265799-qda5awuc 52 22 of of IN cord-265799-qda5awuc 52 23 100 100 CD cord-265799-qda5awuc 52 24 % % NN cord-265799-qda5awuc 52 25 to to TO cord-265799-qda5awuc 52 26 60 60 CD cord-265799-qda5awuc 52 27 % % NN cord-265799-qda5awuc 52 28 , , , cord-265799-qda5awuc 52 29 however however RB cord-265799-qda5awuc 52 30 , , , cord-265799-qda5awuc 52 31 during during IN cord-265799-qda5awuc 52 32 this this DT cord-265799-qda5awuc 52 33 time time NN cord-265799-qda5awuc 52 34 she -PRON- PRP cord-265799-qda5awuc 52 35 continue continue VBP cord-265799-qda5awuc 52 36 to to TO cord-265799-qda5awuc 52 37 require require VB cord-265799-qda5awuc 52 38 vasopressors vasopressor NNS cord-265799-qda5awuc 52 39 for for IN cord-265799-qda5awuc 52 40 distributive distributive JJ cord-265799-qda5awuc 52 41 shock shock NN cord-265799-qda5awuc 52 42 and and CC cord-265799-qda5awuc 52 43 went go VBD cord-265799-qda5awuc 52 44 into into IN cord-265799-qda5awuc 52 45 atrial atrial JJ cord-265799-qda5awuc 52 46 fibrillation fibrillation NN cord-265799-qda5awuc 52 47 with with IN cord-265799-qda5awuc 52 48 rapid rapid JJ cord-265799-qda5awuc 52 49 ventricular ventricular JJ cord-265799-qda5awuc 52 50 rate rate NN cord-265799-qda5awuc 52 51 . . . cord-265799-qda5awuc 53 1 On on IN cord-265799-qda5awuc 53 2 day day NN cord-265799-qda5awuc 53 3 17 17 CD cord-265799-qda5awuc 53 4 , , , cord-265799-qda5awuc 53 5 the the DT cord-265799-qda5awuc 53 6 patient patient NN cord-265799-qda5awuc 53 7 became become VBD cord-265799-qda5awuc 53 8 more more RBR cord-265799-qda5awuc 53 9 hypotensive hypotensive JJ cord-265799-qda5awuc 53 10 requiring require VBG cord-265799-qda5awuc 53 11 reinitiation reinitiation NN cord-265799-qda5awuc 53 12 of of IN cord-265799-qda5awuc 53 13 a a DT cord-265799-qda5awuc 53 14 vasopressin vasopressin NN cord-265799-qda5awuc 53 15 infusion infusion NN cord-265799-qda5awuc 53 16 , , , cord-265799-qda5awuc 53 17 and and CC cord-265799-qda5awuc 53 18 her -PRON- PRP$ cord-265799-qda5awuc 53 19 arterial arterial JJ cord-265799-qda5awuc 53 20 blood blood NN cord-265799-qda5awuc 53 21 gas gas NN cord-265799-qda5awuc 53 22 showed show VBD cord-265799-qda5awuc 53 23 a a DT cord-265799-qda5awuc 53 24 severe severe JJ cord-265799-qda5awuc 53 25 metabolic metabolic JJ cord-265799-qda5awuc 53 26 acidosis acidosis NN cord-265799-qda5awuc 53 27 . . . cord-265799-qda5awuc 54 1 Her -PRON- PRP$ cord-265799-qda5awuc 54 2 ventilatory ventilatory NN cord-265799-qda5awuc 54 3 settings setting NNS cord-265799-qda5awuc 54 4 escalated escalate VBD cord-265799-qda5awuc 54 5 back back RB cord-265799-qda5awuc 54 6 up up IN cord-265799-qda5awuc 54 7 to to IN cord-265799-qda5awuc 54 8 requiring require VBG cord-265799-qda5awuc 54 9 100 100 CD cord-265799-qda5awuc 54 10 % % NN cord-265799-qda5awuc 54 11 FiO2 FiO2 NNS cord-265799-qda5awuc 54 12 , , , cord-265799-qda5awuc 54 13 and and CC cord-265799-qda5awuc 54 14 she -PRON- PRP cord-265799-qda5awuc 54 15 was be VBD cord-265799-qda5awuc 54 16 found find VBN cord-265799-qda5awuc 54 17 to to TO cord-265799-qda5awuc 54 18 be be VB cord-265799-qda5awuc 54 19 hypoglycemic hypoglycemic JJ cord-265799-qda5awuc 54 20 . . . cord-265799-qda5awuc 55 1 Despite despite IN cord-265799-qda5awuc 55 2 our -PRON- PRP$ cord-265799-qda5awuc 55 3 efforts effort NNS cord-265799-qda5awuc 55 4 , , , cord-265799-qda5awuc 55 5 the the DT cord-265799-qda5awuc 55 6 patient patient NN cord-265799-qda5awuc 55 7 went go VBD cord-265799-qda5awuc 55 8 into into IN cord-265799-qda5awuc 55 9 cardiac cardiac JJ cord-265799-qda5awuc 55 10 arrest arrest NN cord-265799-qda5awuc 55 11 on on IN cord-265799-qda5awuc 55 12 the the DT cord-265799-qda5awuc 55 13 evening evening NN cord-265799-qda5awuc 55 14 of of IN cord-265799-qda5awuc 55 15 day day NN cord-265799-qda5awuc 55 16 17 17 CD cord-265799-qda5awuc 55 17 and and CC cord-265799-qda5awuc 55 18 expired expire VBD cord-265799-qda5awuc 55 19 . . . cord-265799-qda5awuc 56 1 It -PRON- PRP cord-265799-qda5awuc 56 2 has have VBZ cord-265799-qda5awuc 56 3 been be VBN cord-265799-qda5awuc 56 4 reported report VBN cord-265799-qda5awuc 56 5 that that IN cord-265799-qda5awuc 56 6 infection infection NN cord-265799-qda5awuc 56 7 with with IN cord-265799-qda5awuc 56 8 SARS SARS NNP cord-265799-qda5awuc 56 9 - - HYPH cord-265799-qda5awuc 56 10 CoV-2 CoV-2 NNP cord-265799-qda5awuc 56 11 is be VBZ cord-265799-qda5awuc 56 12 associated associate VBN cord-265799-qda5awuc 56 13 with with IN cord-265799-qda5awuc 56 14 elevations elevation NNS cord-265799-qda5awuc 56 15 in in IN cord-265799-qda5awuc 56 16 transaminases transaminase NNS cord-265799-qda5awuc 56 17 , , , cord-265799-qda5awuc 56 18 similar similar JJ cord-265799-qda5awuc 56 19 to to IN cord-265799-qda5awuc 56 20 what what WP cord-265799-qda5awuc 56 21 has have VBZ cord-265799-qda5awuc 56 22 been be VBN cord-265799-qda5awuc 56 23 seen see VBN cord-265799-qda5awuc 56 24 in in IN cord-265799-qda5awuc 56 25 the the DT cord-265799-qda5awuc 56 26 original original JJ cord-265799-qda5awuc 56 27 SARS SARS NNP cord-265799-qda5awuc 56 28 - - HYPH cord-265799-qda5awuc 56 29 CoV CoV NNP cord-265799-qda5awuc 56 30 and and CC cord-265799-qda5awuc 56 31 Middle Middle NNP cord-265799-qda5awuc 56 32 East East NNP cord-265799-qda5awuc 56 33 respiratory respiratory JJ cord-265799-qda5awuc 56 34 syndrome syndrome NN cord-265799-qda5awuc 56 35 coronavirus coronavirus NN cord-265799-qda5awuc 56 36 ( ( -LRB- cord-265799-qda5awuc 56 37 MERS MERS NNP cord-265799-qda5awuc 56 38 - - HYPH cord-265799-qda5awuc 56 39 CoV CoV NNP cord-265799-qda5awuc 56 40 ) ) -RRB- cord-265799-qda5awuc 56 41 infections infection NNS cord-265799-qda5awuc 56 42 . . . cord-265799-qda5awuc 57 1 8 8 CD cord-265799-qda5awuc 57 2 , , , cord-265799-qda5awuc 57 3 9 9 CD cord-265799-qda5awuc 57 4 In in IN cord-265799-qda5awuc 57 5 most most JJS cord-265799-qda5awuc 57 6 reports report NNS cord-265799-qda5awuc 57 7 , , , cord-265799-qda5awuc 57 8 however however RB cord-265799-qda5awuc 57 9 , , , cord-265799-qda5awuc 57 10 transaminases transaminase NNS cord-265799-qda5awuc 57 11 have have VBP cord-265799-qda5awuc 57 12 only only RB cord-265799-qda5awuc 57 13 been be VBN cord-265799-qda5awuc 57 14 moderately moderately RB cord-265799-qda5awuc 57 15 elevated elevate VBN cord-265799-qda5awuc 57 16 ( ( -LRB- cord-265799-qda5awuc 57 17 5 5 CD cord-265799-qda5awuc 57 18 - - SYM cord-265799-qda5awuc 57 19 10 10 CD cord-265799-qda5awuc 57 20 times time NNS cord-265799-qda5awuc 57 21 the the DT cord-265799-qda5awuc 57 22 This this DT cord-265799-qda5awuc 57 23 article article NN cord-265799-qda5awuc 57 24 is be VBZ cord-265799-qda5awuc 57 25 protected protect VBN cord-265799-qda5awuc 57 26 by by IN cord-265799-qda5awuc 57 27 copyright copyright NN cord-265799-qda5awuc 57 28 . . . cord-265799-qda5awuc 58 1 All all DT cord-265799-qda5awuc 58 2 rights right NNS cord-265799-qda5awuc 58 3 reserved reserve VBD cord-265799-qda5awuc 58 4 upper upper JJ cord-265799-qda5awuc 58 5 limit limit NN cord-265799-qda5awuc 58 6 of of IN cord-265799-qda5awuc 58 7 normal normal JJ cord-265799-qda5awuc 58 8 ) ) -RRB- cord-265799-qda5awuc 58 9 , , , cord-265799-qda5awuc 58 10 suggesting suggest VBG cord-265799-qda5awuc 58 11 liver liver NN cord-265799-qda5awuc 58 12 injury injury NN cord-265799-qda5awuc 58 13 instead instead RB cord-265799-qda5awuc 58 14 of of IN cord-265799-qda5awuc 58 15 ALF ALF NNP cord-265799-qda5awuc 58 16 . . . cord-265799-qda5awuc 59 1 While while IN cord-265799-qda5awuc 59 2 it -PRON- PRP cord-265799-qda5awuc 59 3 appears appear VBZ cord-265799-qda5awuc 59 4 that that IN cord-265799-qda5awuc 59 5 SARS SARS NNP cord-265799-qda5awuc 59 6 - - HYPH cord-265799-qda5awuc 59 7 CoV-2 CoV-2 NNP cord-265799-qda5awuc 59 8 has have VBZ cord-265799-qda5awuc 59 9 some some DT cord-265799-qda5awuc 59 10 properties property NNS cord-265799-qda5awuc 59 11 that that WDT cord-265799-qda5awuc 59 12 can can MD cord-265799-qda5awuc 59 13 affect affect VB cord-265799-qda5awuc 59 14 the the DT cord-265799-qda5awuc 59 15 liver liver NN cord-265799-qda5awuc 59 16 and and CC cord-265799-qda5awuc 59 17 hepatic hepatic JJ cord-265799-qda5awuc 59 18 function function NN cord-265799-qda5awuc 59 19 , , , cord-265799-qda5awuc 59 20 it -PRON- PRP cord-265799-qda5awuc 59 21 is be VBZ cord-265799-qda5awuc 59 22 also also RB cord-265799-qda5awuc 59 23 important important JJ cord-265799-qda5awuc 59 24 to to TO cord-265799-qda5awuc 59 25 examine examine VB cord-265799-qda5awuc 59 26 if if IN cord-265799-qda5awuc 59 27 the the DT cord-265799-qda5awuc 59 28 therapies therapy NNS cord-265799-qda5awuc 59 29 currently currently RB cord-265799-qda5awuc 59 30 being be VBG cord-265799-qda5awuc 59 31 used use VBN cord-265799-qda5awuc 59 32 for for IN cord-265799-qda5awuc 59 33 the the DT cord-265799-qda5awuc 59 34 treatment treatment NN cord-265799-qda5awuc 59 35 of of IN cord-265799-qda5awuc 59 36 COVID-19 COVID-19 NNP cord-265799-qda5awuc 59 37 may may MD cord-265799-qda5awuc 59 38 also also RB cord-265799-qda5awuc 59 39 cause cause VB cord-265799-qda5awuc 59 40 liver liver NN cord-265799-qda5awuc 59 41 dysfunction dysfunction NN cord-265799-qda5awuc 59 42 either either CC cord-265799-qda5awuc 59 43 independently independently RB cord-265799-qda5awuc 59 44 or or CC cord-265799-qda5awuc 59 45 in in IN cord-265799-qda5awuc 59 46 conjunction conjunction NN cord-265799-qda5awuc 59 47 with with IN cord-265799-qda5awuc 59 48 the the DT cord-265799-qda5awuc 59 49 natural natural JJ cord-265799-qda5awuc 59 50 course course NN cord-265799-qda5awuc 59 51 of of IN cord-265799-qda5awuc 59 52 the the DT cord-265799-qda5awuc 59 53 virus virus NN cord-265799-qda5awuc 59 54 . . . cord-265799-qda5awuc 60 1 Remdesivir Remdesivir NNP cord-265799-qda5awuc 60 2 is be VBZ cord-265799-qda5awuc 60 3 a a DT cord-265799-qda5awuc 60 4 novel novel JJ cord-265799-qda5awuc 60 5 direct direct JJ cord-265799-qda5awuc 60 6 - - HYPH cord-265799-qda5awuc 60 7 acting act VBG cord-265799-qda5awuc 60 8 nucleoside nucleoside NN cord-265799-qda5awuc 60 9 RNA RNA NNP cord-265799-qda5awuc 60 10 polymerase polymerase NN cord-265799-qda5awuc 60 11 inhibitor inhibitor NN cord-265799-qda5awuc 60 12 with with IN cord-265799-qda5awuc 60 13 activity activity NN cord-265799-qda5awuc 60 14 against against IN cord-265799-qda5awuc 60 15 the the DT cord-265799-qda5awuc 60 16 novel novel JJ cord-265799-qda5awuc 60 17 SARS SARS NNP cord-265799-qda5awuc 60 18 - - HYPH cord-265799-qda5awuc 60 19 CoV-2 CoV-2 NNP cord-265799-qda5awuc 60 20 virus virus NN cord-265799-qda5awuc 60 21 used use VBN cord-265799-qda5awuc 60 22 in in IN cord-265799-qda5awuc 60 23 the the DT cord-265799-qda5awuc 60 24 treatment treatment NN cord-265799-qda5awuc 60 25 of of IN cord-265799-qda5awuc 60 26 COVID-19 COVID-19 NNP cord-265799-qda5awuc 60 27 pneumonia pneumonia NN cord-265799-qda5awuc 60 28 . . . cord-265799-qda5awuc 61 1 In in IN cord-265799-qda5awuc 61 2 Phase phase NN cord-265799-qda5awuc 61 3 1 1 CD cord-265799-qda5awuc 61 4 clinical clinical JJ cord-265799-qda5awuc 61 5 trials trial NNS cord-265799-qda5awuc 61 6 in in IN cord-265799-qda5awuc 61 7 healthy healthy JJ cord-265799-qda5awuc 61 8 volunteers volunteer NNS cord-265799-qda5awuc 61 9 , , , cord-265799-qda5awuc 61 10 grade grade NN cord-265799-qda5awuc 61 11 1 1 CD cord-265799-qda5awuc 61 12 and and CC cord-265799-qda5awuc 61 13 2 2 CD cord-265799-qda5awuc 61 14 transaminase transaminase NN cord-265799-qda5awuc 61 15 elevations elevation NNS cord-265799-qda5awuc 61 16 were be VBD cord-265799-qda5awuc 61 17 observed observe VBN cord-265799-qda5awuc 61 18 which which WDT cord-265799-qda5awuc 61 19 resolved resolve VBN cord-265799-qda5awuc 61 20 after after IN cord-265799-qda5awuc 61 21 discontinuation discontinuation NN cord-265799-qda5awuc 61 22 . . . cord-265799-qda5awuc 62 1 7 7 CD cord-265799-qda5awuc 63 1 In in IN cord-265799-qda5awuc 63 2 a a DT cord-265799-qda5awuc 63 3 randomized randomized JJ cord-265799-qda5awuc 63 4 , , , cord-265799-qda5awuc 63 5 double double JJ cord-265799-qda5awuc 63 6 - - HYPH cord-265799-qda5awuc 63 7 blind blind JJ cord-265799-qda5awuc 63 8 , , , cord-265799-qda5awuc 63 9 placebo placebo NN cord-265799-qda5awuc 63 10 - - HYPH cord-265799-qda5awuc 63 11 controlled control VBN cord-265799-qda5awuc 63 12 trial trial NN cord-265799-qda5awuc 63 13 of of IN cord-265799-qda5awuc 63 14 1063 1063 CD cord-265799-qda5awuc 63 15 hospitalized hospitalize VBN cord-265799-qda5awuc 63 16 patients patient NNS cord-265799-qda5awuc 63 17 with with IN cord-265799-qda5awuc 63 18 COVID-19 COVID-19 NNP cord-265799-qda5awuc 63 19 , , , cord-265799-qda5awuc 63 20 there there EX cord-265799-qda5awuc 63 21 was be VBD cord-265799-qda5awuc 63 22 no no DT cord-265799-qda5awuc 63 23 difference difference NN cord-265799-qda5awuc 63 24 in in IN cord-265799-qda5awuc 63 25 the the DT cord-265799-qda5awuc 63 26 incidence incidence NN cord-265799-qda5awuc 63 27 of of IN cord-265799-qda5awuc 63 28 grade grade NN cord-265799-qda5awuc 63 29 ≥3 ≥3 IN cord-265799-qda5awuc 63 30 non non JJ cord-265799-qda5awuc 63 31 - - JJ cord-265799-qda5awuc 63 32 serious serious JJ cord-265799-qda5awuc 63 33 elevations elevation NNS cord-265799-qda5awuc 63 34 of of IN cord-265799-qda5awuc 63 35 AST ast NN cord-265799-qda5awuc 63 36 , , , cord-265799-qda5awuc 63 37 ALT ALT NNP cord-265799-qda5awuc 63 38 , , , cord-265799-qda5awuc 63 39 or or CC cord-265799-qda5awuc 63 40 both both DT cord-265799-qda5awuc 63 41 between between IN cord-265799-qda5awuc 63 42 remdesivir remdesivir NNS cord-265799-qda5awuc 63 43 and and CC cord-265799-qda5awuc 63 44 placebo placebo NN cord-265799-qda5awuc 63 45 ( ( -LRB- cord-265799-qda5awuc 63 46 4.1 4.1 CD cord-265799-qda5awuc 63 47 % % NN cord-265799-qda5awuc 63 48 versus versus IN cord-265799-qda5awuc 63 49 5.9 5.9 CD cord-265799-qda5awuc 63 50 % % NN cord-265799-qda5awuc 63 51 ) ) -RRB- cord-265799-qda5awuc 63 52 . . . cord-265799-qda5awuc 64 1 6 6 CD cord-265799-qda5awuc 64 2 Finally finally RB cord-265799-qda5awuc 64 3 , , , cord-265799-qda5awuc 64 4 in in IN cord-265799-qda5awuc 64 5 a a DT cord-265799-qda5awuc 64 6 randomized randomized JJ cord-265799-qda5awuc 64 7 open open JJ cord-265799-qda5awuc 64 8 - - HYPH cord-265799-qda5awuc 64 9 label label NN cord-265799-qda5awuc 64 10 study study NN cord-265799-qda5awuc 64 11 of of IN cord-265799-qda5awuc 64 12 remdesivir remdesivir NNP cord-265799-qda5awuc 64 13 5 5 CD cord-265799-qda5awuc 64 14 days day NNS cord-265799-qda5awuc 64 15 vs. vs. CC cord-265799-qda5awuc 64 16 10 10 CD cord-265799-qda5awuc 64 17 days day NNS cord-265799-qda5awuc 64 18 for for IN cord-265799-qda5awuc 64 19 the the DT cord-265799-qda5awuc 64 20 treatment treatment NN cord-265799-qda5awuc 64 21 of of IN cord-265799-qda5awuc 64 22 hospitalized hospitalize VBN cord-265799-qda5awuc 64 23 patients patient NNS cord-265799-qda5awuc 64 24 with with IN cord-265799-qda5awuc 64 25 COVID-19 COVID-19 NNP cord-265799-qda5awuc 64 26 , , , cord-265799-qda5awuc 64 27 the the DT cord-265799-qda5awuc 64 28 incidence incidence NN cord-265799-qda5awuc 64 29 of of IN cord-265799-qda5awuc 64 30 grade grade NN cord-265799-qda5awuc 64 31 3 3 CD cord-265799-qda5awuc 64 32 or or CC cord-265799-qda5awuc 64 33 4 4 CD cord-265799-qda5awuc 64 34 elevations elevation NNS cord-265799-qda5awuc 64 35 of of IN cord-265799-qda5awuc 64 36 AST AST NNP cord-265799-qda5awuc 64 37 or or CC cord-265799-qda5awuc 64 38 ALT alt NN cord-265799-qda5awuc 64 39 ranged range VBD cord-265799-qda5awuc 64 40 between between IN cord-265799-qda5awuc 64 41 2 2 CD cord-265799-qda5awuc 64 42 - - SYM cord-265799-qda5awuc 64 43 6 6 CD cord-265799-qda5awuc 64 44 % % NN cord-265799-qda5awuc 64 45 . . . cord-265799-qda5awuc 65 1 10 10 CD cord-265799-qda5awuc 66 1 The the DT cord-265799-qda5awuc 66 2 EUA EUA NNP cord-265799-qda5awuc 66 3 fact fact NN cord-265799-qda5awuc 66 4 sheet sheet NN cord-265799-qda5awuc 66 5 provided provide VBN cord-265799-qda5awuc 66 6 by by IN cord-265799-qda5awuc 66 7 the the DT cord-265799-qda5awuc 66 8 manufacturer manufacturer NN cord-265799-qda5awuc 66 9 states state VBZ cord-265799-qda5awuc 66 10 that that IN cord-265799-qda5awuc 66 11 in in IN cord-265799-qda5awuc 66 12 the the DT cord-265799-qda5awuc 66 13 original original JJ cord-265799-qda5awuc 66 14 compassionate compassionate JJ cord-265799-qda5awuc 66 15 use use NN cord-265799-qda5awuc 66 16 program program NN cord-265799-qda5awuc 66 17 of of IN cord-265799-qda5awuc 66 18 remdesivir remdesivir NNP cord-265799-qda5awuc 66 19 in in IN cord-265799-qda5awuc 66 20 patients patient NNS cord-265799-qda5awuc 66 21 with with IN cord-265799-qda5awuc 66 22 severe severe JJ cord-265799-qda5awuc 66 23 or or CC cord-265799-qda5awuc 66 24 critical critical JJ cord-265799-qda5awuc 66 25 illness illness NN cord-265799-qda5awuc 66 26 with with IN cord-265799-qda5awuc 66 27 COVID-19 COVID-19 NNP cord-265799-qda5awuc 66 28 , , , cord-265799-qda5awuc 66 29 liver liver NN cord-265799-qda5awuc 66 30 function function NN cord-265799-qda5awuc 66 31 test test NN cord-265799-qda5awuc 66 32 abnormalities abnormality NNS cord-265799-qda5awuc 66 33 were be VBD cord-265799-qda5awuc 66 34 reported report VBN cord-265799-qda5awuc 66 35 in in IN cord-265799-qda5awuc 66 36 12 12 CD cord-265799-qda5awuc 66 37 % % NN cord-265799-qda5awuc 66 38 of of IN cord-265799-qda5awuc 66 39 patients patient NNS cord-265799-qda5awuc 66 40 with with IN cord-265799-qda5awuc 66 41 a a DT cord-265799-qda5awuc 66 42 time time NN cord-265799-qda5awuc 66 43 to to TO cord-265799-qda5awuc 66 44 onset onset NN cord-265799-qda5awuc 66 45 from from IN cord-265799-qda5awuc 66 46 first first JJ cord-265799-qda5awuc 66 47 dose dose NN cord-265799-qda5awuc 66 48 ranging range VBG cord-265799-qda5awuc 66 49 from from IN cord-265799-qda5awuc 66 50 1 1 CD cord-265799-qda5awuc 66 51 - - SYM cord-265799-qda5awuc 66 52 16 16 CD cord-265799-qda5awuc 66 53 days day NNS cord-265799-qda5awuc 66 54 . . . cord-265799-qda5awuc 67 1 This this DT cord-265799-qda5awuc 67 2 included include VBD cord-265799-qda5awuc 67 3 cases case NNS cord-265799-qda5awuc 67 4 of of IN cord-265799-qda5awuc 67 5 serious serious JJ cord-265799-qda5awuc 67 6 liver liver NN cord-265799-qda5awuc 67 7 - - HYPH cord-265799-qda5awuc 67 8 related relate VBN cord-265799-qda5awuc 67 9 laboratory laboratory NN cord-265799-qda5awuc 67 10 abnormalities abnormality NNS cord-265799-qda5awuc 67 11 . . . cord-265799-qda5awuc 68 1 7 7 CD cord-265799-qda5awuc 68 2 Outside outside RB cord-265799-qda5awuc 68 3 of of IN cord-265799-qda5awuc 68 4 experiences experience NNS cord-265799-qda5awuc 68 5 discussed discuss VBN cord-265799-qda5awuc 68 6 in in IN cord-265799-qda5awuc 68 7 the the DT cord-265799-qda5awuc 68 8 EUA EUA NNP cord-265799-qda5awuc 68 9 fact fact NN cord-265799-qda5awuc 68 10 sheet sheet NN cord-265799-qda5awuc 68 11 , , , cord-265799-qda5awuc 68 12 very very RB cord-265799-qda5awuc 68 13 little little JJ cord-265799-qda5awuc 68 14 has have VBZ cord-265799-qda5awuc 68 15 been be VBN cord-265799-qda5awuc 68 16 published publish VBN cord-265799-qda5awuc 68 17 regarding regard VBG cord-265799-qda5awuc 68 18 the the DT cord-265799-qda5awuc 68 19 risk risk NN cord-265799-qda5awuc 68 20 of of IN cord-265799-qda5awuc 68 21 ALF ALF NNP cord-265799-qda5awuc 68 22 from from IN cord-265799-qda5awuc 68 23 remdesivir remdesivir NNP cord-265799-qda5awuc 68 24 . . . cord-265799-qda5awuc 69 1 One one CD cord-265799-qda5awuc 69 2 published publish VBN cord-265799-qda5awuc 69 3 case case NN cord-265799-qda5awuc 69 4 report report NN cord-265799-qda5awuc 69 5 by by IN cord-265799-qda5awuc 69 6 Leegwater Leegwater NNP cord-265799-qda5awuc 69 7 discusses discuss VBZ cord-265799-qda5awuc 69 8 a a DT cord-265799-qda5awuc 69 9 case case NN cord-265799-qda5awuc 69 10 of of IN cord-265799-qda5awuc 69 11 acute acute JJ cord-265799-qda5awuc 69 12 liver liver NN cord-265799-qda5awuc 69 13 failure failure NN cord-265799-qda5awuc 69 14 5 5 CD cord-265799-qda5awuc 69 15 days day NNS cord-265799-qda5awuc 69 16 after after IN cord-265799-qda5awuc 69 17 initiation initiation NN cord-265799-qda5awuc 69 18 of of IN cord-265799-qda5awuc 69 19 remdesivir remdesivir NNP cord-265799-qda5awuc 69 20 in in IN cord-265799-qda5awuc 69 21 a a DT cord-265799-qda5awuc 69 22 patient patient NN cord-265799-qda5awuc 69 23 with with IN cord-265799-qda5awuc 69 24 severe severe JJ cord-265799-qda5awuc 69 25 COVID-19 covid-19 JJ cord-265799-qda5awuc 69 26 pneumonia pneumonia NN cord-265799-qda5awuc 69 27 . . . cord-265799-qda5awuc 70 1 11 11 CD cord-265799-qda5awuc 71 1 In in IN cord-265799-qda5awuc 71 2 that that DT cord-265799-qda5awuc 71 3 case case NN cord-265799-qda5awuc 71 4 , , , cord-265799-qda5awuc 71 5 a a DT cord-265799-qda5awuc 71 6 dramatic dramatic JJ cord-265799-qda5awuc 71 7 increase increase NN cord-265799-qda5awuc 71 8 in in IN cord-265799-qda5awuc 71 9 the the DT cord-265799-qda5awuc 71 10 AST AST NNP cord-265799-qda5awuc 71 11 and and CC cord-265799-qda5awuc 71 12 ALT ALT NNP cord-265799-qda5awuc 71 13 to to IN cord-265799-qda5awuc 71 14 1305 1305 CD cord-265799-qda5awuc 71 15 units unit NNS cord-265799-qda5awuc 71 16 / / SYM cord-265799-qda5awuc 71 17 L l NN cord-265799-qda5awuc 71 18 and and CC cord-265799-qda5awuc 71 19 1461 1461 CD cord-265799-qda5awuc 71 20 units unit NNS cord-265799-qda5awuc 71 21 / / SYM cord-265799-qda5awuc 71 22 L l NN cord-265799-qda5awuc 71 23 ( ( -LRB- cord-265799-qda5awuc 71 24 respectively respectively RB cord-265799-qda5awuc 71 25 ) ) -RRB- cord-265799-qda5awuc 71 26 were be VBD cord-265799-qda5awuc 71 27 noted note VBN cord-265799-qda5awuc 71 28 on on IN cord-265799-qda5awuc 71 29 day day NN cord-265799-qda5awuc 71 30 5 5 CD cord-265799-qda5awuc 71 31 of of IN cord-265799-qda5awuc 71 32 remdesivir remdesivir NNP cord-265799-qda5awuc 71 33 therapy therapy NN cord-265799-qda5awuc 71 34 . . . cord-265799-qda5awuc 72 1 The the DT cord-265799-qda5awuc 72 2 authors author NNS cord-265799-qda5awuc 72 3 also also RB cord-265799-qda5awuc 72 4 noted note VBD cord-265799-qda5awuc 72 5 that that IN cord-265799-qda5awuc 72 6 amiodarone amiodarone NN cord-265799-qda5awuc 72 7 was be VBD cord-265799-qda5awuc 72 8 initiated initiate VBN cord-265799-qda5awuc 72 9 on on IN cord-265799-qda5awuc 72 10 day day NN cord-265799-qda5awuc 72 11 2 2 CD cord-265799-qda5awuc 72 12 of of IN cord-265799-qda5awuc 72 13 remdesivir remdesivir NNP cord-265799-qda5awuc 72 14 therapy therapy NN cord-265799-qda5awuc 72 15 and and CC cord-265799-qda5awuc 72 16 postulated postulate VBD cord-265799-qda5awuc 72 17 that that IN cord-265799-qda5awuc 72 18 amiodarone amiodarone NN cord-265799-qda5awuc 72 19 - - HYPH cord-265799-qda5awuc 72 20 induced induce VBN cord-265799-qda5awuc 72 21 inhibition inhibition NN cord-265799-qda5awuc 72 22 of of IN cord-265799-qda5awuc 72 23 P p NN cord-265799-qda5awuc 72 24 - - HYPH cord-265799-qda5awuc 72 25 glycoprotein glycoprotein NN cord-265799-qda5awuc 72 26 efflux efflux NN cord-265799-qda5awuc 72 27 transporters transporter NNS cord-265799-qda5awuc 72 28 ( ( -LRB- cord-265799-qda5awuc 72 29 of of IN cord-265799-qda5awuc 72 30 which which WDT cord-265799-qda5awuc 72 31 remdesivir remdesivir NNP cord-265799-qda5awuc 72 32 is be VBZ cord-265799-qda5awuc 72 33 a a DT cord-265799-qda5awuc 72 34 known know VBN cord-265799-qda5awuc 72 35 substrate substrate NN cord-265799-qda5awuc 72 36 in in IN cord-265799-qda5awuc 72 37 vitro vitro FW cord-265799-qda5awuc 72 38 ) ) -RRB- cord-265799-qda5awuc 72 39 reduces reduce VBZ cord-265799-qda5awuc 72 40 efflux efflux NN cord-265799-qda5awuc 72 41 of of IN cord-265799-qda5awuc 72 42 remdesivir remdesivir NNP cord-265799-qda5awuc 72 43 from from IN cord-265799-qda5awuc 72 44 hepatocytes hepatocyte NNS cord-265799-qda5awuc 72 45 , , , cord-265799-qda5awuc 72 46 increasing increase VBG cord-265799-qda5awuc 72 47 remdesivir remdesivir NNP cord-265799-qda5awuc 72 48 to to IN cord-265799-qda5awuc 72 49 toxic toxic JJ cord-265799-qda5awuc 72 50 concentrations concentration NNS cord-265799-qda5awuc 72 51 . . . cord-265799-qda5awuc 73 1 This this DT cord-265799-qda5awuc 73 2 is be VBZ cord-265799-qda5awuc 73 3 only only RB cord-265799-qda5awuc 73 4 theoretical theoretical JJ cord-265799-qda5awuc 73 5 , , , cord-265799-qda5awuc 73 6 as as IN cord-265799-qda5awuc 73 7 remdesivir remdesivir NNP cord-265799-qda5awuc 73 8 is be VBZ cord-265799-qda5awuc 73 9 listed list VBN cord-265799-qda5awuc 73 10 as as IN cord-265799-qda5awuc 73 11 only only RB cord-265799-qda5awuc 73 12 a a DT cord-265799-qda5awuc 73 13 minor minor JJ cord-265799-qda5awuc 73 14 substrate substrate NN cord-265799-qda5awuc 73 15 of of IN cord-265799-qda5awuc 73 16 P p NN cord-265799-qda5awuc 73 17 - - HYPH cord-265799-qda5awuc 73 18 glycoprotein glycoprotein NN cord-265799-qda5awuc 73 19 efflux efflux NN cord-265799-qda5awuc 73 20 transporters transporter NNS cord-265799-qda5awuc 73 21 and and CC cord-265799-qda5awuc 73 22 has have VBZ cord-265799-qda5awuc 73 23 a a DT cord-265799-qda5awuc 73 24 relatively relatively RB cord-265799-qda5awuc 73 25 short short JJ cord-265799-qda5awuc 73 26 half half JJ cord-265799-qda5awuc 73 27 - - HYPH cord-265799-qda5awuc 73 28 life life NN cord-265799-qda5awuc 73 29 before before IN cord-265799-qda5awuc 73 30 being be VBG cord-265799-qda5awuc 73 31 converted convert VBN cord-265799-qda5awuc 73 32 to to IN cord-265799-qda5awuc 73 33 active active JJ cord-265799-qda5awuc 73 34 metabolites metabolite NNS cord-265799-qda5awuc 73 35 . . . cord-265799-qda5awuc 74 1 12 12 CD cord-265799-qda5awuc 75 1 In in IN cord-265799-qda5awuc 75 2 the the DT cord-265799-qda5awuc 75 3 two two CD cord-265799-qda5awuc 75 4 cases case NNS cord-265799-qda5awuc 75 5 we -PRON- PRP cord-265799-qda5awuc 75 6 present present VBP cord-265799-qda5awuc 75 7 , , , cord-265799-qda5awuc 75 8 the the DT cord-265799-qda5awuc 75 9 time time NN cord-265799-qda5awuc 75 10 course course NN cord-265799-qda5awuc 75 11 of of IN cord-265799-qda5awuc 75 12 COVID-19 covid-19 JJ cord-265799-qda5awuc 75 13 infection infection NN cord-265799-qda5awuc 75 14 , , , cord-265799-qda5awuc 75 15 remdesivir remdesivir NNP cord-265799-qda5awuc 75 16 administration administration NN cord-265799-qda5awuc 75 17 , , , cord-265799-qda5awuc 75 18 and and CC cord-265799-qda5awuc 75 19 liver liver NN cord-265799-qda5awuc 75 20 function function NN cord-265799-qda5awuc 75 21 abnormalities abnormality NNS cord-265799-qda5awuc 75 22 appears appear VBZ cord-265799-qda5awuc 75 23 to to TO cord-265799-qda5awuc 75 24 point point VB cord-265799-qda5awuc 75 25 to to IN cord-265799-qda5awuc 75 26 remdesivir remdesivir NNP cord-265799-qda5awuc 75 27 as as IN cord-265799-qda5awuc 75 28 a a DT cord-265799-qda5awuc 75 29 possible possible JJ cord-265799-qda5awuc 75 30 contributing contribute VBG cord-265799-qda5awuc 75 31 cause cause NN cord-265799-qda5awuc 75 32 of of IN cord-265799-qda5awuc 75 33 ALF ALF NNP cord-265799-qda5awuc 75 34 . . . cord-265799-qda5awuc 76 1 When when WRB cord-265799-qda5awuc 76 2 utilizing utilize VBG cord-265799-qda5awuc 76 3 the the DT cord-265799-qda5awuc 76 4 Naranjo Naranjo NNP cord-265799-qda5awuc 76 5 algorithm algorithm NN cord-265799-qda5awuc 76 6 to to TO cord-265799-qda5awuc 76 7 determine determine VB cord-265799-qda5awuc 76 8 the the DT cord-265799-qda5awuc 76 9 possibility possibility NN cord-265799-qda5awuc 76 10 of of IN cord-265799-qda5awuc 76 11 a a DT cord-265799-qda5awuc 76 12 drug drug NN cord-265799-qda5awuc 76 13 - - HYPH cord-265799-qda5awuc 76 14 induced induce VBN cord-265799-qda5awuc 76 15 effect effect NN cord-265799-qda5awuc 76 16 , , , cord-265799-qda5awuc 76 17 both both DT cord-265799-qda5awuc 76 18 cases case NNS cord-265799-qda5awuc 76 19 scored score VBD cord-265799-qda5awuc 76 20 as as IN cord-265799-qda5awuc 76 21 a a DT cord-265799-qda5awuc 76 22 " " `` cord-265799-qda5awuc 76 23 probable probable JJ cord-265799-qda5awuc 76 24 " " '' cord-265799-qda5awuc 76 25 adverse adverse JJ cord-265799-qda5awuc 76 26 drug drug NN cord-265799-qda5awuc 76 27 reaction reaction NN cord-265799-qda5awuc 76 28 with with IN cord-265799-qda5awuc 76 29 a a DT cord-265799-qda5awuc 76 30 score score NN cord-265799-qda5awuc 76 31 of of IN cord-265799-qda5awuc 76 32 6 6 CD cord-265799-qda5awuc 76 33 each each DT cord-265799-qda5awuc 76 34 . . . cord-265799-qda5awuc 76 35 13 13 CD cord-265799-qda5awuc 77 1 In in IN cord-265799-qda5awuc 77 2 the the DT cord-265799-qda5awuc 77 3 first first JJ cord-265799-qda5awuc 77 4 case case NN cord-265799-qda5awuc 77 5 presented present VBN cord-265799-qda5awuc 77 6 , , , cord-265799-qda5awuc 77 7 ALF ALF NNP cord-265799-qda5awuc 77 8 was be VBD cord-265799-qda5awuc 77 9 noted note VBN cord-265799-qda5awuc 77 10 on on IN cord-265799-qda5awuc 77 11 day day NN cord-265799-qda5awuc 77 12 3 3 CD cord-265799-qda5awuc 77 13 of of IN cord-265799-qda5awuc 77 14 remdesivir remdesivir NNP cord-265799-qda5awuc 77 15 therapy therapy NN cord-265799-qda5awuc 77 16 . . . cord-265799-qda5awuc 78 1 Though though IN cord-265799-qda5awuc 78 2 amiodarone amiodarone NN cord-265799-qda5awuc 78 3 can can MD cord-265799-qda5awuc 78 4 rarely rarely RB cord-265799-qda5awuc 78 5 cause cause VB cord-265799-qda5awuc 78 6 ALF ALF NNP cord-265799-qda5awuc 78 7 , , , cord-265799-qda5awuc 78 8 it -PRON- PRP cord-265799-qda5awuc 78 9 is be VBZ cord-265799-qda5awuc 78 10 unlikely unlikely JJ cord-265799-qda5awuc 78 11 to to TO cord-265799-qda5awuc 78 12 be be VB cord-265799-qda5awuc 78 13 the the DT cord-265799-qda5awuc 78 14 cause cause NN cord-265799-qda5awuc 78 15 in in IN cord-265799-qda5awuc 78 16 this this DT cord-265799-qda5awuc 78 17 case case NN cord-265799-qda5awuc 78 18 as as IN cord-265799-qda5awuc 78 19 the the DT cord-265799-qda5awuc 78 20 This this DT cord-265799-qda5awuc 78 21 article article NN cord-265799-qda5awuc 78 22 is be VBZ cord-265799-qda5awuc 78 23 protected protect VBN cord-265799-qda5awuc 78 24 by by IN cord-265799-qda5awuc 78 25 copyright copyright NN cord-265799-qda5awuc 78 26 . . . cord-265799-qda5awuc 79 1 All all DT cord-265799-qda5awuc 79 2 rights right NNS cord-265799-qda5awuc 79 3 reserved reserve VBN cord-265799-qda5awuc 79 4 ALT ALT NNP cord-265799-qda5awuc 79 5 was be VBD cord-265799-qda5awuc 79 6 already already RB cord-265799-qda5awuc 79 7 beginning begin VBG cord-265799-qda5awuc 79 8 to to TO cord-265799-qda5awuc 79 9 trend trend VB cord-265799-qda5awuc 79 10 upward upward RB cord-265799-qda5awuc 79 11 on on IN cord-265799-qda5awuc 79 12 the the DT cord-265799-qda5awuc 79 13 day day NN cord-265799-qda5awuc 79 14 amiodarone amiodarone NN cord-265799-qda5awuc 79 15 was be VBD cord-265799-qda5awuc 79 16 initiated initiate VBN cord-265799-qda5awuc 79 17 . . . cord-265799-qda5awuc 80 1 Also also RB cord-265799-qda5awuc 80 2 , , , cord-265799-qda5awuc 80 3 the the DT cord-265799-qda5awuc 80 4 ALT ALT NNP cord-265799-qda5awuc 80 5 began begin VBD cord-265799-qda5awuc 80 6 to to TO cord-265799-qda5awuc 80 7 resolve resolve VB cord-265799-qda5awuc 80 8 very very RB cord-265799-qda5awuc 80 9 rapidly rapidly RB cord-265799-qda5awuc 80 10 with with IN cord-265799-qda5awuc 80 11 discontinuation discontinuation NN cord-265799-qda5awuc 80 12 of of IN cord-265799-qda5awuc 80 13 remdesivir remdesivir NNS cord-265799-qda5awuc 80 14 and and CC cord-265799-qda5awuc 80 15 amiodarone amiodarone NN cord-265799-qda5awuc 80 16 and and CC cord-265799-qda5awuc 80 17 initiation initiation NN cord-265799-qda5awuc 80 18 of of IN cord-265799-qda5awuc 80 19 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 80 20 ; ; : cord-265799-qda5awuc 80 21 as as IN cord-265799-qda5awuc 80 22 amiodarone amiodarone NN cord-265799-qda5awuc 80 23 has have VBZ cord-265799-qda5awuc 80 24 a a DT cord-265799-qda5awuc 80 25 half half JJ cord-265799-qda5awuc 80 26 - - HYPH cord-265799-qda5awuc 80 27 life life NN cord-265799-qda5awuc 80 28 of of IN cord-265799-qda5awuc 80 29 9 9 CD cord-265799-qda5awuc 80 30 - - SYM cord-265799-qda5awuc 80 31 142 142 CD cord-265799-qda5awuc 80 32 days day NNS cord-265799-qda5awuc 80 33 ( ( -LRB- cord-265799-qda5awuc 80 34 depending depend VBG cord-265799-qda5awuc 80 35 on on IN cord-265799-qda5awuc 80 36 formulation formulation NN cord-265799-qda5awuc 80 37 and and CC cord-265799-qda5awuc 80 38 duration duration NN cord-265799-qda5awuc 80 39 of of IN cord-265799-qda5awuc 80 40 therapy therapy NN cord-265799-qda5awuc 80 41 ) ) -RRB- cord-265799-qda5awuc 80 42 , , , cord-265799-qda5awuc 80 43 if if IN cord-265799-qda5awuc 80 44 amiodarone amiodarone NN cord-265799-qda5awuc 80 45 was be VBD cord-265799-qda5awuc 80 46 the the DT cord-265799-qda5awuc 80 47 cause cause NN cord-265799-qda5awuc 80 48 of of IN cord-265799-qda5awuc 80 49 the the DT cord-265799-qda5awuc 80 50 ALF ALF NNP cord-265799-qda5awuc 80 51 , , , cord-265799-qda5awuc 80 52 it -PRON- PRP cord-265799-qda5awuc 80 53 is be VBZ cord-265799-qda5awuc 80 54 not not RB cord-265799-qda5awuc 80 55 expected expect VBN cord-265799-qda5awuc 80 56 that that IN cord-265799-qda5awuc 80 57 discontinuation discontinuation NN cord-265799-qda5awuc 80 58 would would MD cord-265799-qda5awuc 80 59 lead lead VB cord-265799-qda5awuc 80 60 to to IN cord-265799-qda5awuc 80 61 such such JJ cord-265799-qda5awuc 80 62 rapid rapid JJ cord-265799-qda5awuc 80 63 resolution resolution NN cord-265799-qda5awuc 80 64 . . . cord-265799-qda5awuc 81 1 14 14 CD cord-265799-qda5awuc 82 1 In in IN cord-265799-qda5awuc 82 2 the the DT cord-265799-qda5awuc 82 3 second second JJ cord-265799-qda5awuc 82 4 case case NN cord-265799-qda5awuc 82 5 , , , cord-265799-qda5awuc 82 6 the the DT cord-265799-qda5awuc 82 7 sudden sudden JJ cord-265799-qda5awuc 82 8 increase increase NN cord-265799-qda5awuc 82 9 in in IN cord-265799-qda5awuc 82 10 transaminases transaminase NNS cord-265799-qda5awuc 82 11 was be VBD cord-265799-qda5awuc 82 12 5 5 CD cord-265799-qda5awuc 82 13 days day NNS cord-265799-qda5awuc 82 14 after after IN cord-265799-qda5awuc 82 15 completing complete VBG cord-265799-qda5awuc 82 16 remdesivir remdesivir NNP cord-265799-qda5awuc 82 17 but but CC cord-265799-qda5awuc 82 18 still still RB cord-265799-qda5awuc 82 19 within within IN cord-265799-qda5awuc 82 20 the the DT cord-265799-qda5awuc 82 21 time time NN cord-265799-qda5awuc 82 22 range range NN cord-265799-qda5awuc 82 23 described describe VBN cord-265799-qda5awuc 82 24 in in IN cord-265799-qda5awuc 82 25 the the DT cord-265799-qda5awuc 82 26 EUA EUA NNP cord-265799-qda5awuc 82 27 fact fact NN cord-265799-qda5awuc 82 28 sheet sheet NN cord-265799-qda5awuc 82 29 . . . cord-265799-qda5awuc 83 1 The the DT cord-265799-qda5awuc 83 2 patient patient NN cord-265799-qda5awuc 83 3 did do VBD cord-265799-qda5awuc 83 4 experience experience NN cord-265799-qda5awuc 83 5 severe severe JJ cord-265799-qda5awuc 83 6 distributive distributive JJ cord-265799-qda5awuc 83 7 shock shock NN cord-265799-qda5awuc 83 8 the the DT cord-265799-qda5awuc 83 9 day day NN cord-265799-qda5awuc 83 10 before before IN cord-265799-qda5awuc 83 11 evidence evidence NN cord-265799-qda5awuc 83 12 of of IN cord-265799-qda5awuc 83 13 overt overt JJ cord-265799-qda5awuc 83 14 liver liver NN cord-265799-qda5awuc 83 15 failure failure NN cord-265799-qda5awuc 83 16 , , , cord-265799-qda5awuc 83 17 requiring require VBG cord-265799-qda5awuc 83 18 high high JJ cord-265799-qda5awuc 83 19 dose dose NN cord-265799-qda5awuc 83 20 vasopressors vasopressor NNS cord-265799-qda5awuc 83 21 for for IN cord-265799-qda5awuc 83 22 a a DT cord-265799-qda5awuc 83 23 short short JJ cord-265799-qda5awuc 83 24 time time NN cord-265799-qda5awuc 83 25 . . . cord-265799-qda5awuc 84 1 Hepatic hepatic JJ cord-265799-qda5awuc 84 2 ischemia ischemia NN cord-265799-qda5awuc 84 3 from from IN cord-265799-qda5awuc 84 4 distributive distributive JJ cord-265799-qda5awuc 84 5 shock shock NN cord-265799-qda5awuc 84 6 could could MD cord-265799-qda5awuc 84 7 have have VB cord-265799-qda5awuc 84 8 been be VBN cord-265799-qda5awuc 84 9 a a DT cord-265799-qda5awuc 84 10 contributing contribute VBG cord-265799-qda5awuc 84 11 factor factor NN cord-265799-qda5awuc 84 12 in in IN cord-265799-qda5awuc 84 13 development development NN cord-265799-qda5awuc 84 14 of of IN cord-265799-qda5awuc 84 15 ALF ALF NNP cord-265799-qda5awuc 84 16 , , , cord-265799-qda5awuc 84 17 but but CC cord-265799-qda5awuc 84 18 increasing increase VBG cord-265799-qda5awuc 84 19 markers marker NNS cord-265799-qda5awuc 84 20 of of IN cord-265799-qda5awuc 84 21 liver liver NN cord-265799-qda5awuc 84 22 injury injury NN cord-265799-qda5awuc 84 23 ( ( -LRB- cord-265799-qda5awuc 84 24 increasing increase VBG cord-265799-qda5awuc 84 25 alkaline alkaline JJ cord-265799-qda5awuc 84 26 phosphatase phosphatase NN cord-265799-qda5awuc 84 27 several several JJ cord-265799-qda5awuc 84 28 days day NNS cord-265799-qda5awuc 84 29 before before IN cord-265799-qda5awuc 84 30 vasopressor vasopressor NN cord-265799-qda5awuc 84 31 initiation initiation NN cord-265799-qda5awuc 84 32 ) ) -RRB- cord-265799-qda5awuc 84 33 prior prior RB cord-265799-qda5awuc 84 34 to to IN cord-265799-qda5awuc 84 35 the the DT cord-265799-qda5awuc 84 36 patient patient NN cord-265799-qda5awuc 84 37 experiencing experience VBG cord-265799-qda5awuc 84 38 shock shock NN cord-265799-qda5awuc 84 39 along along IN cord-265799-qda5awuc 84 40 with with IN cord-265799-qda5awuc 84 41 the the DT cord-265799-qda5awuc 84 42 timing timing NN cord-265799-qda5awuc 84 43 of of IN cord-265799-qda5awuc 84 44 the the DT cord-265799-qda5awuc 84 45 recent recent JJ cord-265799-qda5awuc 84 46 remdesivir remdesivir JJ cord-265799-qda5awuc 84 47 exposure exposure NN cord-265799-qda5awuc 85 1 indicates indicate VBZ cord-265799-qda5awuc 85 2 that that IN cord-265799-qda5awuc 85 3 there there EX cord-265799-qda5awuc 85 4 is be VBZ cord-265799-qda5awuc 85 5 a a DT cord-265799-qda5awuc 85 6 possibility possibility NN cord-265799-qda5awuc 85 7 of of IN cord-265799-qda5awuc 85 8 remdesivir remdesivir NNP cord-265799-qda5awuc 85 9 also also RB cord-265799-qda5awuc 85 10 contributing contribute VBG cord-265799-qda5awuc 85 11 to to IN cord-265799-qda5awuc 85 12 ALF ALF NNP cord-265799-qda5awuc 85 13 . . . cord-265799-qda5awuc 86 1 The the DT cord-265799-qda5awuc 86 2 patient patient NN cord-265799-qda5awuc 86 3 also also RB cord-265799-qda5awuc 86 4 received receive VBD cord-265799-qda5awuc 86 5 tocilizumab tocilizumab NNP cord-265799-qda5awuc 86 6 two two CD cord-265799-qda5awuc 86 7 days day NNS cord-265799-qda5awuc 86 8 prior prior RB cord-265799-qda5awuc 86 9 to to IN cord-265799-qda5awuc 86 10 experiencing experience VBG cord-265799-qda5awuc 86 11 ALF ALF NNP cord-265799-qda5awuc 86 12 . . . cord-265799-qda5awuc 87 1 Tocilizumab Tocilizumab NNP cord-265799-qda5awuc 87 2 has have VBZ cord-265799-qda5awuc 87 3 been be VBN cord-265799-qda5awuc 87 4 associated associate VBN cord-265799-qda5awuc 87 5 with with IN cord-265799-qda5awuc 87 6 mild mild JJ cord-265799-qda5awuc 87 7 transaminitis transaminitis NN cord-265799-qda5awuc 87 8 ( ( -LRB- cord-265799-qda5awuc 87 9 AST AST NNP cord-265799-qda5awuc 87 10 / / SYM cord-265799-qda5awuc 87 11 ALT ALT NNP cord-265799-qda5awuc 87 12 1 1 CD cord-265799-qda5awuc 87 13 - - SYM cord-265799-qda5awuc 87 14 5 5 CD cord-265799-qda5awuc 87 15 times time NNS cord-265799-qda5awuc 87 16 the the DT cord-265799-qda5awuc 87 17 upper upper JJ cord-265799-qda5awuc 87 18 limit limit NN cord-265799-qda5awuc 87 19 of of IN cord-265799-qda5awuc 87 20 normal normal JJ cord-265799-qda5awuc 87 21 ) ) -RRB- cord-265799-qda5awuc 87 22 in in IN cord-265799-qda5awuc 87 23 acute acute JJ cord-265799-qda5awuc 87 24 use use NN cord-265799-qda5awuc 87 25 that that WDT cord-265799-qda5awuc 87 26 tends tend VBZ cord-265799-qda5awuc 87 27 to to TO cord-265799-qda5awuc 87 28 resolve resolve VB cord-265799-qda5awuc 87 29 quickly quickly RB cord-265799-qda5awuc 87 30 , , , cord-265799-qda5awuc 87 31 and and CC cord-265799-qda5awuc 87 32 there there EX cord-265799-qda5awuc 87 33 have have VBP cord-265799-qda5awuc 87 34 been be VBN cord-265799-qda5awuc 87 35 cases case NNS cord-265799-qda5awuc 87 36 of of IN cord-265799-qda5awuc 87 37 severe severe JJ cord-265799-qda5awuc 87 38 liver liver NN cord-265799-qda5awuc 87 39 injury injury NN cord-265799-qda5awuc 87 40 linked link VBN cord-265799-qda5awuc 87 41 to to IN cord-265799-qda5awuc 87 42 tocilizumab tocilizumab NNP cord-265799-qda5awuc 87 43 use use NN cord-265799-qda5awuc 87 44 . . . cord-265799-qda5awuc 88 1 15 15 CD cord-265799-qda5awuc 89 1 In in IN cord-265799-qda5awuc 89 2 these these DT cord-265799-qda5awuc 89 3 cases case NNS cord-265799-qda5awuc 89 4 , , , cord-265799-qda5awuc 89 5 however however RB cord-265799-qda5awuc 89 6 , , , cord-265799-qda5awuc 89 7 severe severe JJ cord-265799-qda5awuc 89 8 liver liver NN cord-265799-qda5awuc 89 9 injury injury NN cord-265799-qda5awuc 89 10 was be VBD cord-265799-qda5awuc 89 11 usually usually RB cord-265799-qda5awuc 89 12 associated associate VBN cord-265799-qda5awuc 89 13 with with IN cord-265799-qda5awuc 89 14 several several JJ cord-265799-qda5awuc 89 15 months month NNS cord-265799-qda5awuc 89 16 of of IN cord-265799-qda5awuc 89 17 tocilizumab tocilizumab NN cord-265799-qda5awuc 89 18 therapy therapy NN cord-265799-qda5awuc 89 19 , , , cord-265799-qda5awuc 89 20 where where WRB cord-265799-qda5awuc 89 21 our -PRON- PRP$ cord-265799-qda5awuc 89 22 patient patient NN cord-265799-qda5awuc 89 23 only only RB cord-265799-qda5awuc 89 24 received receive VBD cord-265799-qda5awuc 89 25 a a DT cord-265799-qda5awuc 89 26 single single JJ cord-265799-qda5awuc 89 27 dose dose NN cord-265799-qda5awuc 89 28 prior prior RB cord-265799-qda5awuc 89 29 to to IN cord-265799-qda5awuc 89 30 ALF ALF NNP cord-265799-qda5awuc 89 31 . . . cord-265799-qda5awuc 90 1 Drug drug NN cord-265799-qda5awuc 90 2 - - HYPH cord-265799-qda5awuc 90 3 induced induce VBN cord-265799-qda5awuc 90 4 liver liver NN cord-265799-qda5awuc 90 5 injury injury NN cord-265799-qda5awuc 90 6 ( ( -LRB- cord-265799-qda5awuc 90 7 DILI DILI NNP cord-265799-qda5awuc 90 8 ) ) -RRB- cord-265799-qda5awuc 90 9 is be VBZ cord-265799-qda5awuc 90 10 a a DT cord-265799-qda5awuc 90 11 serious serious JJ cord-265799-qda5awuc 90 12 adverse adverse JJ cord-265799-qda5awuc 90 13 effect effect NN cord-265799-qda5awuc 90 14 of of IN cord-265799-qda5awuc 90 15 medications medication NNS cord-265799-qda5awuc 90 16 that that WDT cord-265799-qda5awuc 90 17 can can MD cord-265799-qda5awuc 90 18 range range VB cord-265799-qda5awuc 90 19 in in IN cord-265799-qda5awuc 90 20 presentation presentation NN cord-265799-qda5awuc 90 21 from from IN cord-265799-qda5awuc 90 22 mild mild JJ cord-265799-qda5awuc 90 23 transaminitis transaminitis NN cord-265799-qda5awuc 90 24 to to IN cord-265799-qda5awuc 90 25 fulminant fulminant JJ cord-265799-qda5awuc 90 26 liver liver NN cord-265799-qda5awuc 90 27 failure failure NN cord-265799-qda5awuc 90 28 and and CC cord-265799-qda5awuc 90 29 represents represent VBZ cord-265799-qda5awuc 90 30 one one CD cord-265799-qda5awuc 90 31 of of IN cord-265799-qda5awuc 90 32 the the DT cord-265799-qda5awuc 90 33 most most RBS cord-265799-qda5awuc 90 34 common common JJ cord-265799-qda5awuc 90 35 causes cause NNS cord-265799-qda5awuc 90 36 of of IN cord-265799-qda5awuc 90 37 acute acute JJ cord-265799-qda5awuc 90 38 liver liver NN cord-265799-qda5awuc 90 39 failure failure NN cord-265799-qda5awuc 90 40 . . . cord-265799-qda5awuc 91 1 16 16 CD cord-265799-qda5awuc 92 1 Acetaminophen acetaminophen NN cord-265799-qda5awuc 92 2 is be VBZ cord-265799-qda5awuc 92 3 the the DT cord-265799-qda5awuc 92 4 leading leading JJ cord-265799-qda5awuc 92 5 cause cause NN cord-265799-qda5awuc 92 6 of of IN cord-265799-qda5awuc 92 7 ALF ALF NNP cord-265799-qda5awuc 92 8 in in IN cord-265799-qda5awuc 92 9 the the DT cord-265799-qda5awuc 92 10 United United NNP cord-265799-qda5awuc 92 11 States States NNP cord-265799-qda5awuc 92 12 and and CC cord-265799-qda5awuc 92 13 Europe Europe NNP cord-265799-qda5awuc 92 14 , , , cord-265799-qda5awuc 92 15 though though IN cord-265799-qda5awuc 92 16 there there EX cord-265799-qda5awuc 92 17 are be VBP cord-265799-qda5awuc 92 18 many many JJ cord-265799-qda5awuc 92 19 other other JJ cord-265799-qda5awuc 92 20 medications medication NNS cord-265799-qda5awuc 92 21 associated associate VBN cord-265799-qda5awuc 92 22 with with IN cord-265799-qda5awuc 92 23 DILI DILI NNP cord-265799-qda5awuc 92 24 and and CC cord-265799-qda5awuc 92 25 ALF ALF NNP cord-265799-qda5awuc 92 26 . . . cord-265799-qda5awuc 93 1 Acetylcysteine Acetylcysteine NNP cord-265799-qda5awuc 93 2 is be VBZ cord-265799-qda5awuc 93 3 the the DT cord-265799-qda5awuc 93 4 antidote antidote NN cord-265799-qda5awuc 93 5 for for IN cord-265799-qda5awuc 93 6 acetaminophen acetaminophen NN cord-265799-qda5awuc 93 7 toxicity toxicity NN cord-265799-qda5awuc 93 8 , , , cord-265799-qda5awuc 93 9 and and CC cord-265799-qda5awuc 93 10 though though IN cord-265799-qda5awuc 93 11 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 93 12 is be VBZ cord-265799-qda5awuc 93 13 only only RB cord-265799-qda5awuc 93 14 indicated indicate VBN cord-265799-qda5awuc 93 15 for for IN cord-265799-qda5awuc 93 16 treatment treatment NN cord-265799-qda5awuc 93 17 of of IN cord-265799-qda5awuc 93 18 acetaminophen acetaminophen NN cord-265799-qda5awuc 93 19 - - HYPH cord-265799-qda5awuc 93 20 induced induce VBN cord-265799-qda5awuc 93 21 liver liver NN cord-265799-qda5awuc 93 22 failure failure NN cord-265799-qda5awuc 93 23 , , , cord-265799-qda5awuc 93 24 some some DT cord-265799-qda5awuc 93 25 guidelines guideline NNS cord-265799-qda5awuc 93 26 recommend recommend VBP cord-265799-qda5awuc 93 27 the the DT cord-265799-qda5awuc 93 28 use use NN cord-265799-qda5awuc 93 29 of of IN cord-265799-qda5awuc 93 30 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 93 31 in in IN cord-265799-qda5awuc 93 32 non non JJ cord-265799-qda5awuc 93 33 - - JJ cord-265799-qda5awuc 93 34 acetaminophen acetaminophen JJ cord-265799-qda5awuc 93 35 - - HYPH cord-265799-qda5awuc 93 36 induced induce VBN cord-265799-qda5awuc 93 37 ALF ALF NNP cord-265799-qda5awuc 93 38 ( ( -LRB- cord-265799-qda5awuc 93 39 NAI NAI NNP cord-265799-qda5awuc 93 40 - - HYPH cord-265799-qda5awuc 93 41 ALF ALF NNP cord-265799-qda5awuc 93 42 ) ) -RRB- cord-265799-qda5awuc 93 43 while while IN cord-265799-qda5awuc 93 44 others other NNS cord-265799-qda5awuc 93 45 recommend recommend VBP cord-265799-qda5awuc 93 46 its -PRON- PRP$ cord-265799-qda5awuc 93 47 use use NN cord-265799-qda5awuc 93 48 only only RB cord-265799-qda5awuc 93 49 in in IN cord-265799-qda5awuc 93 50 the the DT cord-265799-qda5awuc 93 51 context context NN cord-265799-qda5awuc 93 52 of of IN cord-265799-qda5awuc 93 53 clinical clinical JJ cord-265799-qda5awuc 93 54 trials trial NNS cord-265799-qda5awuc 93 55 . . . cord-265799-qda5awuc 94 1 [ [ -LRB- cord-265799-qda5awuc 94 2 16 16 CD cord-265799-qda5awuc 94 3 ] ] -RRB- cord-265799-qda5awuc 94 4 [ [ -LRB- cord-265799-qda5awuc 94 5 17 17 CD cord-265799-qda5awuc 94 6 ] ] -RRB- cord-265799-qda5awuc 94 7 [ [ -LRB- cord-265799-qda5awuc 94 8 18 18 CD cord-265799-qda5awuc 94 9 ] ] -RRB- cord-265799-qda5awuc 95 1 Though though IN cord-265799-qda5awuc 95 2 there there EX cord-265799-qda5awuc 95 3 are be VBP cord-265799-qda5awuc 95 4 different different JJ cord-265799-qda5awuc 95 5 etiologies etiology NNS cord-265799-qda5awuc 95 6 of of IN cord-265799-qda5awuc 95 7 ALF ALF NNP cord-265799-qda5awuc 95 8 , , , cord-265799-qda5awuc 95 9 the the DT cord-265799-qda5awuc 95 10 loss loss NN cord-265799-qda5awuc 95 11 of of IN cord-265799-qda5awuc 95 12 hepatocellular hepatocellular JJ cord-265799-qda5awuc 95 13 function function NN cord-265799-qda5awuc 95 14 commonly commonly RB cord-265799-qda5awuc 95 15 leads lead VBZ cord-265799-qda5awuc 95 16 to to IN cord-265799-qda5awuc 95 17 multisystem multisystem JJ cord-265799-qda5awuc 95 18 organ organ NN cord-265799-qda5awuc 95 19 failure failure NN cord-265799-qda5awuc 95 20 if if IN cord-265799-qda5awuc 95 21 not not RB cord-265799-qda5awuc 95 22 addressed address VBN cord-265799-qda5awuc 95 23 . . . cord-265799-qda5awuc 96 1 While while IN cord-265799-qda5awuc 96 2 treatment treatment NN cord-265799-qda5awuc 96 3 of of IN cord-265799-qda5awuc 96 4 DILI DILI NNP cord-265799-qda5awuc 96 5 revolves revolve VBZ cord-265799-qda5awuc 96 6 around around RB cord-265799-qda5awuc 96 7 stopping stop VBG cord-265799-qda5awuc 96 8 the the DT cord-265799-qda5awuc 96 9 offending offend VBG cord-265799-qda5awuc 96 10 agent agent NN cord-265799-qda5awuc 96 11 , , , cord-265799-qda5awuc 96 12 other other JJ cord-265799-qda5awuc 96 13 supportive supportive JJ cord-265799-qda5awuc 96 14 measures measure NNS cord-265799-qda5awuc 96 15 are be VBP cord-265799-qda5awuc 96 16 often often RB cord-265799-qda5awuc 96 17 needed need VBN cord-265799-qda5awuc 96 18 , , , cord-265799-qda5awuc 96 19 including include VBG cord-265799-qda5awuc 96 20 administration administration NN cord-265799-qda5awuc 96 21 of of IN cord-265799-qda5awuc 96 22 an an DT cord-265799-qda5awuc 96 23 antidote antidote NN cord-265799-qda5awuc 96 24 if if IN cord-265799-qda5awuc 96 25 available available JJ cord-265799-qda5awuc 96 26 , , , cord-265799-qda5awuc 96 27 achieving achieve VBG cord-265799-qda5awuc 96 28 hemodynamic hemodynamic JJ cord-265799-qda5awuc 96 29 stability stability NN cord-265799-qda5awuc 96 30 , , , cord-265799-qda5awuc 96 31 reversing reverse VBG cord-265799-qda5awuc 96 32 coagulopathies coagulopathie NNS cord-265799-qda5awuc 96 33 , , , cord-265799-qda5awuc 96 34 treating treat VBG cord-265799-qda5awuc 96 35 encephalopathies encephalopathy NNS cord-265799-qda5awuc 96 36 , , , cord-265799-qda5awuc 96 37 and and CC cord-265799-qda5awuc 96 38 consideration consideration NN cord-265799-qda5awuc 96 39 of of IN cord-265799-qda5awuc 96 40 liver liver NN cord-265799-qda5awuc 96 41 transplantation transplantation NN cord-265799-qda5awuc 96 42 . . . cord-265799-qda5awuc 97 1 19 19 CD cord-265799-qda5awuc 98 1 While while IN cord-265799-qda5awuc 98 2 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 98 3 acts act VBZ cord-265799-qda5awuc 98 4 as as IN cord-265799-qda5awuc 98 5 a a DT cord-265799-qda5awuc 98 6 glutathione glutathione NN cord-265799-qda5awuc 98 7 precursor precursor NN cord-265799-qda5awuc 98 8 in in IN cord-265799-qda5awuc 98 9 acetaminophen acetaminophen NN cord-265799-qda5awuc 98 10 toxicity toxicity NN cord-265799-qda5awuc 98 11 , , , cord-265799-qda5awuc 98 12 its -PRON- PRP$ cord-265799-qda5awuc 98 13 mechanism mechanism NN cord-265799-qda5awuc 98 14 of of IN cord-265799-qda5awuc 98 15 action action NN cord-265799-qda5awuc 98 16 in in IN cord-265799-qda5awuc 98 17 NAI NAI NNP cord-265799-qda5awuc 98 18 - - HYPH cord-265799-qda5awuc 98 19 ALF ALF NNP cord-265799-qda5awuc 98 20 is be VBZ cord-265799-qda5awuc 98 21 not not RB cord-265799-qda5awuc 98 22 as as RB cord-265799-qda5awuc 98 23 clear clear JJ cord-265799-qda5awuc 98 24 , , , cord-265799-qda5awuc 98 25 though though IN cord-265799-qda5awuc 98 26 it -PRON- PRP cord-265799-qda5awuc 98 27 is be VBZ cord-265799-qda5awuc 98 28 hypothesized hypothesize VBN cord-265799-qda5awuc 98 29 that that IN cord-265799-qda5awuc 98 30 acetylcysteine acetylcysteine NNP cord-265799-qda5awuc 98 31 's 's POS cord-265799-qda5awuc 98 32 antioxidant antioxidant NN cord-265799-qda5awuc 98 33 and and CC cord-265799-qda5awuc 98 34 vasodilatory vasodilatory NN cord-265799-qda5awuc 98 35 properties property NNS cord-265799-qda5awuc 98 36 may may MD cord-265799-qda5awuc 98 37 provide provide VB cord-265799-qda5awuc 98 38 some some DT cord-265799-qda5awuc 98 39 benefit benefit NN cord-265799-qda5awuc 98 40 . . . cord-265799-qda5awuc 99 1 19 19 CD cord-265799-qda5awuc 100 1 This this DT cord-265799-qda5awuc 100 2 article article NN cord-265799-qda5awuc 100 3 is be VBZ cord-265799-qda5awuc 100 4 protected protect VBN cord-265799-qda5awuc 100 5 by by IN cord-265799-qda5awuc 100 6 copyright copyright NN cord-265799-qda5awuc 100 7 . . . cord-265799-qda5awuc 101 1 All all DT cord-265799-qda5awuc 101 2 rights right NNS cord-265799-qda5awuc 101 3 reserved reserve VBD cord-265799-qda5awuc 101 4 Acetylcysteine acetylcysteine NN cord-265799-qda5awuc 101 5 use use NN cord-265799-qda5awuc 101 6 in in IN cord-265799-qda5awuc 101 7 NAI NAI NNP cord-265799-qda5awuc 101 8 - - HYPH cord-265799-qda5awuc 101 9 ALF ALF NNP cord-265799-qda5awuc 101 10 is be VBZ cord-265799-qda5awuc 101 11 controversial controversial JJ cord-265799-qda5awuc 101 12 due due IN cord-265799-qda5awuc 101 13 to to IN cord-265799-qda5awuc 101 14 the the DT cord-265799-qda5awuc 101 15 lack lack NN cord-265799-qda5awuc 101 16 of of IN cord-265799-qda5awuc 101 17 data datum NNS cord-265799-qda5awuc 101 18 conclusively conclusively RB cord-265799-qda5awuc 101 19 showing show VBG cord-265799-qda5awuc 101 20 benefits benefit NNS cord-265799-qda5awuc 101 21 . . . cord-265799-qda5awuc 102 1 Initial initial JJ cord-265799-qda5awuc 102 2 trials trial NNS cord-265799-qda5awuc 102 3 assessing assess VBG cord-265799-qda5awuc 102 4 the the DT cord-265799-qda5awuc 102 5 use use NN cord-265799-qda5awuc 102 6 of of IN cord-265799-qda5awuc 102 7 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 102 8 in in IN cord-265799-qda5awuc 102 9 NAI NAI NNP cord-265799-qda5awuc 102 10 - - HYPH cord-265799-qda5awuc 102 11 ALF ALF NNP cord-265799-qda5awuc 102 12 in in IN cord-265799-qda5awuc 102 13 adults adult NNS cord-265799-qda5awuc 102 14 found find VBD cord-265799-qda5awuc 102 15 conflicting conflict VBG cord-265799-qda5awuc 102 16 results result NNS cord-265799-qda5awuc 102 17 . . . cord-265799-qda5awuc 103 1 A a DT cord-265799-qda5awuc 103 2 prospective prospective NN cord-265799-qda5awuc 103 3 , , , cord-265799-qda5awuc 103 4 randomized randomized JJ cord-265799-qda5awuc 103 5 , , , cord-265799-qda5awuc 103 6 double double JJ cord-265799-qda5awuc 103 7 - - HYPH cord-265799-qda5awuc 103 8 blind blind JJ cord-265799-qda5awuc 103 9 trial trial NN cord-265799-qda5awuc 103 10 by by IN cord-265799-qda5awuc 103 11 Lee Lee NNP cord-265799-qda5awuc 103 12 et et NNP cord-265799-qda5awuc 103 13 al al NNP cord-265799-qda5awuc 103 14 . . . cord-265799-qda5awuc 104 1 found find VBD cord-265799-qda5awuc 104 2 higher high JJR cord-265799-qda5awuc 104 3 transplant transplant NN cord-265799-qda5awuc 104 4 - - HYPH cord-265799-qda5awuc 104 5 free free JJ cord-265799-qda5awuc 104 6 survival survival NN cord-265799-qda5awuc 104 7 only only RB cord-265799-qda5awuc 104 8 in in IN cord-265799-qda5awuc 104 9 patients patient NNS cord-265799-qda5awuc 104 10 with with IN cord-265799-qda5awuc 104 11 coma coma NN cord-265799-qda5awuc 104 12 grades grade NNS cord-265799-qda5awuc 104 13 I I NNP cord-265799-qda5awuc 104 14 - - HYPH cord-265799-qda5awuc 104 15 II II NNP cord-265799-qda5awuc 104 16 ( ( -LRB- cord-265799-qda5awuc 104 17 representing represent VBG cord-265799-qda5awuc 104 18 earlier early JJR cord-265799-qda5awuc 104 19 stage stage NN cord-265799-qda5awuc 104 20 liver liver NN cord-265799-qda5awuc 104 21 failure failure NN cord-265799-qda5awuc 104 22 ) ) -RRB- cord-265799-qda5awuc 104 23 treated treat VBN cord-265799-qda5awuc 104 24 with with IN cord-265799-qda5awuc 104 25 intravenous intravenous JJ cord-265799-qda5awuc 104 26 ( ( -LRB- cord-265799-qda5awuc 104 27 IV IV NNP cord-265799-qda5awuc 104 28 ) ) -RRB- cord-265799-qda5awuc 104 29 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 104 30 compared compare VBN cord-265799-qda5awuc 104 31 with with IN cord-265799-qda5awuc 104 32 placebo placebo NN cord-265799-qda5awuc 104 33 . . . cord-265799-qda5awuc 105 1 20 20 CD cord-265799-qda5awuc 106 1 This this DT cord-265799-qda5awuc 106 2 contrasts contrast VBZ cord-265799-qda5awuc 106 3 with with IN cord-265799-qda5awuc 106 4 a a DT cord-265799-qda5awuc 106 5 study study NN cord-265799-qda5awuc 106 6 by by IN cord-265799-qda5awuc 106 7 Mumtaz Mumtaz NNP cord-265799-qda5awuc 106 8 et et NNP cord-265799-qda5awuc 106 9 al al NNP cord-265799-qda5awuc 106 10 . . . cord-265799-qda5awuc 107 1 who who WP cord-265799-qda5awuc 107 2 conducted conduct VBD cord-265799-qda5awuc 107 3 a a DT cord-265799-qda5awuc 107 4 prospective prospective JJ cord-265799-qda5awuc 107 5 trial trial NN cord-265799-qda5awuc 107 6 assessing assess VBG cord-265799-qda5awuc 107 7 an an DT cord-265799-qda5awuc 107 8 oral oral JJ cord-265799-qda5awuc 107 9 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 107 10 protocol protocol NN cord-265799-qda5awuc 107 11 compared compare VBN cord-265799-qda5awuc 107 12 with with IN cord-265799-qda5awuc 107 13 a a DT cord-265799-qda5awuc 107 14 historical historical JJ cord-265799-qda5awuc 107 15 control control NN cord-265799-qda5awuc 107 16 group group NN cord-265799-qda5awuc 107 17 . . . cord-265799-qda5awuc 108 1 While while IN cord-265799-qda5awuc 108 2 the the DT cord-265799-qda5awuc 108 3 primary primary JJ cord-265799-qda5awuc 108 4 cause cause NN cord-265799-qda5awuc 108 5 of of IN cord-265799-qda5awuc 108 6 ALF ALF NNP cord-265799-qda5awuc 108 7 in in IN cord-265799-qda5awuc 108 8 this this DT cord-265799-qda5awuc 108 9 trial trial NN cord-265799-qda5awuc 108 10 was be VBD cord-265799-qda5awuc 108 11 acute acute JJ cord-265799-qda5awuc 108 12 hepatitis hepatitis NN cord-265799-qda5awuc 108 13 , , , cord-265799-qda5awuc 108 14 the the DT cord-265799-qda5awuc 108 15 authors author NNS cord-265799-qda5awuc 108 16 found find VBD cord-265799-qda5awuc 108 17 that that IN cord-265799-qda5awuc 108 18 not not RB cord-265799-qda5awuc 108 19 using use VBG cord-265799-qda5awuc 108 20 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 108 21 was be VBD cord-265799-qda5awuc 108 22 an an DT cord-265799-qda5awuc 108 23 independent independent JJ cord-265799-qda5awuc 108 24 predictor predictor NN cord-265799-qda5awuc 108 25 of of IN cord-265799-qda5awuc 108 26 mortality mortality NN cord-265799-qda5awuc 108 27 while while IN cord-265799-qda5awuc 108 28 also also RB cord-265799-qda5awuc 108 29 reporting report VBG cord-265799-qda5awuc 108 30 no no DT cord-265799-qda5awuc 108 31 significant significant JJ cord-265799-qda5awuc 108 32 adverse adverse JJ cord-265799-qda5awuc 108 33 effects effect NNS cord-265799-qda5awuc 108 34 from from IN cord-265799-qda5awuc 108 35 its -PRON- PRP$ cord-265799-qda5awuc 108 36 use use NN cord-265799-qda5awuc 108 37 . . . cord-265799-qda5awuc 109 1 21 21 CD cord-265799-qda5awuc 110 1 Subsequent subsequent JJ cord-265799-qda5awuc 110 2 trials trial NNS cord-265799-qda5awuc 110 3 in in IN cord-265799-qda5awuc 110 4 adults adult NNS cord-265799-qda5awuc 110 5 with with IN cord-265799-qda5awuc 110 6 NAI NAI NNP cord-265799-qda5awuc 110 7 - - HYPH cord-265799-qda5awuc 110 8 ALF ALF NNP cord-265799-qda5awuc 110 9 have have VBP cord-265799-qda5awuc 110 10 continued continue VBN cord-265799-qda5awuc 110 11 to to TO cord-265799-qda5awuc 110 12 support support VB cord-265799-qda5awuc 110 13 the the DT cord-265799-qda5awuc 110 14 hypothesis hypothesis NN cord-265799-qda5awuc 110 15 of of IN cord-265799-qda5awuc 110 16 benefit benefit NN cord-265799-qda5awuc 110 17 from from IN cord-265799-qda5awuc 110 18 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 110 19 , , , cord-265799-qda5awuc 110 20 though though IN cord-265799-qda5awuc 110 21 they -PRON- PRP cord-265799-qda5awuc 110 22 have have VBP cord-265799-qda5awuc 110 23 been be VBN cord-265799-qda5awuc 110 24 retrospective retrospective JJ cord-265799-qda5awuc 110 25 or or CC cord-265799-qda5awuc 110 26 small small JJ cord-265799-qda5awuc 110 27 . . . cord-265799-qda5awuc 111 1 Darweesh Darweesh NNP cord-265799-qda5awuc 111 2 at at IN cord-265799-qda5awuc 111 3 al al NNP cord-265799-qda5awuc 111 4 . . NNP cord-265799-qda5awuc 111 5 conducted conduct VBD cord-265799-qda5awuc 111 6 a a DT cord-265799-qda5awuc 111 7 prospective prospective JJ cord-265799-qda5awuc 111 8 observational observational JJ cord-265799-qda5awuc 111 9 trial trial NN cord-265799-qda5awuc 111 10 with with IN cord-265799-qda5awuc 111 11 historical historical JJ cord-265799-qda5awuc 111 12 control control NN cord-265799-qda5awuc 111 13 of of IN cord-265799-qda5awuc 111 14 adults adult NNS cord-265799-qda5awuc 111 15 admitted admit VBN cord-265799-qda5awuc 111 16 with with IN cord-265799-qda5awuc 111 17 NAI NAI NNP cord-265799-qda5awuc 111 18 - - HYPH cord-265799-qda5awuc 111 19 ALF ALF NNP cord-265799-qda5awuc 111 20 . . . cord-265799-qda5awuc 112 1 They -PRON- PRP cord-265799-qda5awuc 112 2 found find VBD cord-265799-qda5awuc 112 3 that that IN cord-265799-qda5awuc 112 4 patients patient NNS cord-265799-qda5awuc 112 5 given give VBN cord-265799-qda5awuc 112 6 IV IV NNP cord-265799-qda5awuc 112 7 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 112 8 on on IN cord-265799-qda5awuc 112 9 admission admission NN cord-265799-qda5awuc 112 10 had have VBD cord-265799-qda5awuc 112 11 a a DT cord-265799-qda5awuc 112 12 significant significant JJ cord-265799-qda5awuc 112 13 improvement improvement NN cord-265799-qda5awuc 112 14 in in IN cord-265799-qda5awuc 112 15 transplant transplant NN cord-265799-qda5awuc 112 16 - - HYPH cord-265799-qda5awuc 112 17 free free JJ cord-265799-qda5awuc 112 18 survival survival NN cord-265799-qda5awuc 112 19 ( ( -LRB- cord-265799-qda5awuc 112 20 96.4 96.4 CD cord-265799-qda5awuc 112 21 % % NN cord-265799-qda5awuc 112 22 vs. vs. CC cord-265799-qda5awuc 112 23 23.3 23.3 CD cord-265799-qda5awuc 112 24 % % NN cord-265799-qda5awuc 112 25 in in IN cord-265799-qda5awuc 112 26 the the DT cord-265799-qda5awuc 112 27 placebo placebo NN cord-265799-qda5awuc 112 28 group group NN cord-265799-qda5awuc 112 29 ) ) -RRB- cord-265799-qda5awuc 112 30 along along IN cord-265799-qda5awuc 112 31 with with IN cord-265799-qda5awuc 112 32 reduction reduction NN cord-265799-qda5awuc 112 33 in in IN cord-265799-qda5awuc 112 34 hospital hospital NN cord-265799-qda5awuc 112 35 length length NN cord-265799-qda5awuc 112 36 of of IN cord-265799-qda5awuc 112 37 stay stay NN cord-265799-qda5awuc 112 38 , , , cord-265799-qda5awuc 112 39 bleeding bleed VBG cord-265799-qda5awuc 112 40 , , , cord-265799-qda5awuc 112 41 and and CC cord-265799-qda5awuc 112 42 encephalopathy encephalopathy NN cord-265799-qda5awuc 112 43 in in IN cord-265799-qda5awuc 112 44 the the DT cord-265799-qda5awuc 112 45 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 112 46 group group NN cord-265799-qda5awuc 112 47 . . . cord-265799-qda5awuc 113 1 22 22 CD cord-265799-qda5awuc 114 1 These these DT cord-265799-qda5awuc 114 2 results result NNS cord-265799-qda5awuc 114 3 show show VBP cord-265799-qda5awuc 114 4 a a DT cord-265799-qda5awuc 114 5 much much RB cord-265799-qda5awuc 114 6 more more RBR cord-265799-qda5awuc 114 7 significant significant JJ cord-265799-qda5awuc 114 8 benefit benefit NN cord-265799-qda5awuc 114 9 than than IN cord-265799-qda5awuc 114 10 previously previously RB cord-265799-qda5awuc 114 11 seen see VBN cord-265799-qda5awuc 114 12 , , , cord-265799-qda5awuc 114 13 though though IN cord-265799-qda5awuc 114 14 this this DT cord-265799-qda5awuc 114 15 could could MD cord-265799-qda5awuc 114 16 be be VB cord-265799-qda5awuc 114 17 due due JJ cord-265799-qda5awuc 114 18 to to IN cord-265799-qda5awuc 114 19 the the DT cord-265799-qda5awuc 114 20 small small JJ cord-265799-qda5awuc 114 21 , , , cord-265799-qda5awuc 114 22 observational observational JJ cord-265799-qda5awuc 114 23 nature nature NN cord-265799-qda5awuc 114 24 of of IN cord-265799-qda5awuc 114 25 the the DT cord-265799-qda5awuc 114 26 trial trial NN cord-265799-qda5awuc 114 27 . . . cord-265799-qda5awuc 115 1 Finally finally RB cord-265799-qda5awuc 115 2 , , , cord-265799-qda5awuc 115 3 Nabi Nabi NNP cord-265799-qda5awuc 115 4 et et NNP cord-265799-qda5awuc 115 5 al al NNP cord-265799-qda5awuc 115 6 . . NNP cord-265799-qda5awuc 115 7 conducted conduct VBD cord-265799-qda5awuc 115 8 a a DT cord-265799-qda5awuc 115 9 prospective prospective NN cord-265799-qda5awuc 115 10 , , , cord-265799-qda5awuc 115 11 randomized randomized JJ cord-265799-qda5awuc 115 12 trial trial NN cord-265799-qda5awuc 115 13 comparing compare VBG cord-265799-qda5awuc 115 14 IV IV NNP cord-265799-qda5awuc 115 15 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 115 16 to to IN cord-265799-qda5awuc 115 17 placebo placebo NN cord-265799-qda5awuc 115 18 for for IN cord-265799-qda5awuc 115 19 treatment treatment NN cord-265799-qda5awuc 115 20 of of IN cord-265799-qda5awuc 115 21 NAI NAI NNP cord-265799-qda5awuc 115 22 - - HYPH cord-265799-qda5awuc 115 23 ALF ALF NNP cord-265799-qda5awuc 115 24 . . . cord-265799-qda5awuc 116 1 The the DT cord-265799-qda5awuc 116 2 authors author NNS cord-265799-qda5awuc 116 3 found find VBD cord-265799-qda5awuc 116 4 that that IN cord-265799-qda5awuc 116 5 the the DT cord-265799-qda5awuc 116 6 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 116 7 group group NN cord-265799-qda5awuc 116 8 had have VBD cord-265799-qda5awuc 116 9 significantly significantly RB cord-265799-qda5awuc 116 10 lower low JJR cord-265799-qda5awuc 116 11 mortality mortality NN cord-265799-qda5awuc 116 12 and and CC cord-265799-qda5awuc 116 13 hospital hospital NN cord-265799-qda5awuc 116 14 length length NN cord-265799-qda5awuc 116 15 of of IN cord-265799-qda5awuc 116 16 stay stay NN cord-265799-qda5awuc 116 17 compared compare VBN cord-265799-qda5awuc 116 18 to to IN cord-265799-qda5awuc 116 19 the the DT cord-265799-qda5awuc 116 20 placebo placebo NN cord-265799-qda5awuc 116 21 group group NN cord-265799-qda5awuc 116 22 and and CC cord-265799-qda5awuc 116 23 that that IN cord-265799-qda5awuc 116 24 not not RB cord-265799-qda5awuc 116 25 using use VBG cord-265799-qda5awuc 116 26 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 116 27 was be VBD cord-265799-qda5awuc 116 28 an an DT cord-265799-qda5awuc 116 29 independent independent JJ cord-265799-qda5awuc 116 30 risk risk NN cord-265799-qda5awuc 116 31 factor factor NN cord-265799-qda5awuc 116 32 for for IN cord-265799-qda5awuc 116 33 death death NN cord-265799-qda5awuc 116 34 . . . cord-265799-qda5awuc 117 1 23 23 CD cord-265799-qda5awuc 118 1 It -PRON- PRP cord-265799-qda5awuc 118 2 is be VBZ cord-265799-qda5awuc 118 3 important important JJ cord-265799-qda5awuc 118 4 to to TO cord-265799-qda5awuc 118 5 note note VB cord-265799-qda5awuc 118 6 that that IN cord-265799-qda5awuc 118 7 suspected suspect VBN cord-265799-qda5awuc 118 8 DILI DILI NNP cord-265799-qda5awuc 118 9 only only RB cord-265799-qda5awuc 118 10 accounted account VBD cord-265799-qda5awuc 118 11 for for IN cord-265799-qda5awuc 118 12 anywhere anywhere RB cord-265799-qda5awuc 118 13 from from IN cord-265799-qda5awuc 118 14 6 6 CD cord-265799-qda5awuc 118 15 - - SYM cord-265799-qda5awuc 118 16 40 40 CD cord-265799-qda5awuc 118 17 % % NN cord-265799-qda5awuc 118 18 of of IN cord-265799-qda5awuc 118 19 NAI NAI NNP cord-265799-qda5awuc 118 20 - - HYPH cord-265799-qda5awuc 118 21 ALF ALF NNP cord-265799-qda5awuc 118 22 cases case NNS cord-265799-qda5awuc 118 23 in in IN cord-265799-qda5awuc 118 24 the the DT cord-265799-qda5awuc 118 25 different different JJ cord-265799-qda5awuc 118 26 studies study NNS cord-265799-qda5awuc 118 27 , , , cord-265799-qda5awuc 118 28 indicating indicate VBG cord-265799-qda5awuc 118 29 the the DT cord-265799-qda5awuc 118 30 difficulty difficulty NN cord-265799-qda5awuc 118 31 in in IN cord-265799-qda5awuc 118 32 applying apply VBG cord-265799-qda5awuc 118 33 the the DT cord-265799-qda5awuc 118 34 limited limited JJ cord-265799-qda5awuc 118 35 literature literature NN cord-265799-qda5awuc 118 36 to to IN cord-265799-qda5awuc 118 37 a a DT cord-265799-qda5awuc 118 38 case case NN cord-265799-qda5awuc 118 39 of of IN cord-265799-qda5awuc 118 40 suspected suspect VBN cord-265799-qda5awuc 118 41 ALF ALF NNP cord-265799-qda5awuc 118 42 from from IN cord-265799-qda5awuc 118 43 a a DT cord-265799-qda5awuc 118 44 novel novel NN cord-265799-qda5awuc 118 45 , , , cord-265799-qda5awuc 118 46 unapproved unapproved JJ cord-265799-qda5awuc 118 47 medication medication NN cord-265799-qda5awuc 118 48 used use VBN cord-265799-qda5awuc 118 49 in in IN cord-265799-qda5awuc 118 50 an an DT cord-265799-qda5awuc 118 51 emergency emergency NN cord-265799-qda5awuc 118 52 setting setting NN cord-265799-qda5awuc 118 53 . . . cord-265799-qda5awuc 119 1 To to IN cord-265799-qda5awuc 119 2 date date NN cord-265799-qda5awuc 119 3 , , , cord-265799-qda5awuc 119 4 it -PRON- PRP cord-265799-qda5awuc 119 5 remains remain VBZ cord-265799-qda5awuc 119 6 unclear unclear JJ cord-265799-qda5awuc 119 7 what what WP cord-265799-qda5awuc 119 8 the the DT cord-265799-qda5awuc 119 9 true true JJ cord-265799-qda5awuc 119 10 risk risk NN cord-265799-qda5awuc 119 11 and and CC cord-265799-qda5awuc 119 12 prevalence prevalence NN cord-265799-qda5awuc 119 13 of of IN cord-265799-qda5awuc 119 14 ALF ALF NNP cord-265799-qda5awuc 119 15 from from IN cord-265799-qda5awuc 119 16 remdesivir remdesivir NNP cord-265799-qda5awuc 119 17 use use NN cord-265799-qda5awuc 119 18 is be VBZ cord-265799-qda5awuc 119 19 in in IN cord-265799-qda5awuc 119 20 the the DT cord-265799-qda5awuc 119 21 setting setting NN cord-265799-qda5awuc 119 22 of of IN cord-265799-qda5awuc 119 23 COVID-19 covid-19 NN cord-265799-qda5awuc 119 24 . . . cord-265799-qda5awuc 120 1 Remdesivir Remdesivir NNP cord-265799-qda5awuc 120 2 has have VBZ cord-265799-qda5awuc 120 3 been be VBN cord-265799-qda5awuc 120 4 studied study VBN cord-265799-qda5awuc 120 5 in in IN cord-265799-qda5awuc 120 6 humans human NNS cord-265799-qda5awuc 120 7 previously previously RB cord-265799-qda5awuc 120 8 for for IN cord-265799-qda5awuc 120 9 the the DT cord-265799-qda5awuc 120 10 treatment treatment NN cord-265799-qda5awuc 120 11 of of IN cord-265799-qda5awuc 120 12 the the DT cord-265799-qda5awuc 120 13 Ebola Ebola NNP cord-265799-qda5awuc 120 14 virus virus NN cord-265799-qda5awuc 120 15 , , , cord-265799-qda5awuc 120 16 but but CC cord-265799-qda5awuc 120 17 it -PRON- PRP cord-265799-qda5awuc 120 18 has have VBZ cord-265799-qda5awuc 120 19 only only RB cord-265799-qda5awuc 120 20 been be VBN cord-265799-qda5awuc 120 21 widely widely RB cord-265799-qda5awuc 120 22 available available JJ cord-265799-qda5awuc 120 23 for for IN cord-265799-qda5awuc 120 24 clinical clinical JJ cord-265799-qda5awuc 120 25 use use NN cord-265799-qda5awuc 120 26 during during IN cord-265799-qda5awuc 120 27 the the DT cord-265799-qda5awuc 120 28 SARS SARS NNP cord-265799-qda5awuc 120 29 - - HYPH cord-265799-qda5awuc 120 30 CoV-2 CoV-2 NNP cord-265799-qda5awuc 120 31 pandemic pandemic NN cord-265799-qda5awuc 120 32 . . . cord-265799-qda5awuc 121 1 While while IN cord-265799-qda5awuc 121 2 remdesivir remdesivir NNP cord-265799-qda5awuc 121 3 has have VBZ cord-265799-qda5awuc 121 4 been be VBN cord-265799-qda5awuc 121 5 shown show VBN cord-265799-qda5awuc 121 6 to to TO cord-265799-qda5awuc 121 7 be be VB cord-265799-qda5awuc 121 8 relatively relatively RB cord-265799-qda5awuc 121 9 safe safe JJ cord-265799-qda5awuc 121 10 in in IN cord-265799-qda5awuc 121 11 the the DT cord-265799-qda5awuc 121 12 context context NN cord-265799-qda5awuc 121 13 of of IN cord-265799-qda5awuc 121 14 limited limited JJ cord-265799-qda5awuc 121 15 use use NN cord-265799-qda5awuc 121 16 , , , cord-265799-qda5awuc 121 17 there there EX cord-265799-qda5awuc 121 18 is be VBZ cord-265799-qda5awuc 121 19 a a DT cord-265799-qda5awuc 121 20 possibility possibility NN cord-265799-qda5awuc 121 21 that that IN cord-265799-qda5awuc 121 22 widespread widespread JJ cord-265799-qda5awuc 121 23 use use NN cord-265799-qda5awuc 121 24 will will MD cord-265799-qda5awuc 121 25 reveal reveal VB cord-265799-qda5awuc 121 26 new new JJ cord-265799-qda5awuc 121 27 safety safety NN cord-265799-qda5awuc 121 28 concerns concern NNS cord-265799-qda5awuc 121 29 that that WDT cord-265799-qda5awuc 121 30 must must MD cord-265799-qda5awuc 121 31 be be VB cord-265799-qda5awuc 121 32 accounted account VBN cord-265799-qda5awuc 121 33 for for IN cord-265799-qda5awuc 121 34 when when WRB cord-265799-qda5awuc 121 35 weighing weigh VBG cord-265799-qda5awuc 121 36 the the DT cord-265799-qda5awuc 121 37 risks risk NNS cord-265799-qda5awuc 121 38 vs. vs. IN cord-265799-qda5awuc 121 39 benefits benefit NNS cord-265799-qda5awuc 121 40 of of IN cord-265799-qda5awuc 121 41 use use NN cord-265799-qda5awuc 121 42 . . . cord-265799-qda5awuc 122 1 The the DT cord-265799-qda5awuc 122 2 incidence incidence NN cord-265799-qda5awuc 122 3 of of IN cord-265799-qda5awuc 122 4 transaminitis transaminitis NN cord-265799-qda5awuc 122 5 seen see VBN cord-265799-qda5awuc 122 6 in in IN cord-265799-qda5awuc 122 7 previous previous JJ cord-265799-qda5awuc 122 8 clinical clinical JJ cord-265799-qda5awuc 122 9 trials trial NNS cord-265799-qda5awuc 122 10 of of IN cord-265799-qda5awuc 122 11 remdesivir remdesivir NNP cord-265799-qda5awuc 122 12 suggests suggest VBZ cord-265799-qda5awuc 122 13 there there EX cord-265799-qda5awuc 122 14 is be VBZ cord-265799-qda5awuc 122 15 a a DT cord-265799-qda5awuc 122 16 possibility possibility NN cord-265799-qda5awuc 122 17 of of IN cord-265799-qda5awuc 122 18 unexpected unexpected JJ cord-265799-qda5awuc 122 19 ALF ALF NNP cord-265799-qda5awuc 122 20 . . . cord-265799-qda5awuc 123 1 While while IN cord-265799-qda5awuc 123 2 there there EX cord-265799-qda5awuc 123 3 is be VBZ cord-265799-qda5awuc 123 4 very very RB cord-265799-qda5awuc 123 5 limited limited JJ cord-265799-qda5awuc 123 6 evidence evidence NN cord-265799-qda5awuc 123 7 supporting support VBG cord-265799-qda5awuc 123 8 the the DT cord-265799-qda5awuc 123 9 use use NN cord-265799-qda5awuc 123 10 of of IN cord-265799-qda5awuc 123 11 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 123 12 for for IN cord-265799-qda5awuc 123 13 NAI NAI NNP cord-265799-qda5awuc 123 14 - - HYPH cord-265799-qda5awuc 123 15 ALF ALF NNP cord-265799-qda5awuc 123 16 ( ( -LRB- cord-265799-qda5awuc 123 17 and and CC cord-265799-qda5awuc 123 18 there there EX cord-265799-qda5awuc 123 19 is be VBZ cord-265799-qda5awuc 123 20 no no DT cord-265799-qda5awuc 123 21 data data NN cord-265799-qda5awuc 123 22 on on IN cord-265799-qda5awuc 123 23 its -PRON- PRP$ cord-265799-qda5awuc 123 24 use use NN cord-265799-qda5awuc 123 25 in in IN cord-265799-qda5awuc 123 26 remdesivir remdesivir NNP cord-265799-qda5awuc 123 27 - - HYPH cord-265799-qda5awuc 123 28 associated associate VBN cord-265799-qda5awuc 123 29 ALF ALF NNP cord-265799-qda5awuc 123 30 ) ) -RRB- cord-265799-qda5awuc 123 31 , , , cord-265799-qda5awuc 123 32 both both DT cord-265799-qda5awuc 123 33 of of IN cord-265799-qda5awuc 123 34 these these DT cord-265799-qda5awuc 123 35 cases case NNS cord-265799-qda5awuc 123 36 of of IN cord-265799-qda5awuc 123 37 remdesivir remdesivir NNP cord-265799-qda5awuc 123 38 - - HYPH cord-265799-qda5awuc 123 39 associated associate VBN cord-265799-qda5awuc 123 40 acute acute JJ cord-265799-qda5awuc 123 41 , , , cord-265799-qda5awuc 123 42 fulminant fulminant JJ cord-265799-qda5awuc 123 43 ALF ALF NNP cord-265799-qda5awuc 123 44 showed show VBD cord-265799-qda5awuc 123 45 improvement improvement NN cord-265799-qda5awuc 123 46 in in IN cord-265799-qda5awuc 123 47 ALF ALF NNP cord-265799-qda5awuc 123 48 with with IN cord-265799-qda5awuc 123 49 its -PRON- PRP$ cord-265799-qda5awuc 123 50 use use NN cord-265799-qda5awuc 123 51 in in IN cord-265799-qda5awuc 123 52 conjunction conjunction NN cord-265799-qda5awuc 123 53 with with IN cord-265799-qda5awuc 123 54 discontinuation discontinuation NN cord-265799-qda5awuc 123 55 of of IN cord-265799-qda5awuc 123 56 potentially potentially RB cord-265799-qda5awuc 123 57 hepatotoxic hepatotoxic JJ cord-265799-qda5awuc 123 58 medications medication NNS cord-265799-qda5awuc 123 59 without without IN cord-265799-qda5awuc 123 60 any any DT cord-265799-qda5awuc 123 61 experiencing experience VBG cord-265799-qda5awuc 123 62 any any DT cord-265799-qda5awuc 123 63 adverse adverse JJ cord-265799-qda5awuc 123 64 effects effect NNS cord-265799-qda5awuc 123 65 . . . cord-265799-qda5awuc 123 66 _SP cord-265799-qda5awuc 124 1 Characteristics characteristic NNS cord-265799-qda5awuc 124 2 of of IN cord-265799-qda5awuc 124 3 and and CC cord-265799-qda5awuc 124 4 important important JJ cord-265799-qda5awuc 124 5 lessons lesson NNS cord-265799-qda5awuc 124 6 from from IN cord-265799-qda5awuc 124 7 the the DT cord-265799-qda5awuc 124 8 coronavirus coronavirus NN cord-265799-qda5awuc 124 9 disease disease NN cord-265799-qda5awuc 124 10 2019 2019 CD cord-265799-qda5awuc 124 11 ( ( -LRB- cord-265799-qda5awuc 124 12 COVID-19 COVID-19 NNP cord-265799-qda5awuc 124 13 ) ) -RRB- cord-265799-qda5awuc 124 14 outbreak outbreak NN cord-265799-qda5awuc 124 15 in in IN cord-265799-qda5awuc 124 16 China China NNP cord-265799-qda5awuc 124 17 Centers Centers NNPS cord-265799-qda5awuc 124 18 for for IN cord-265799-qda5awuc 124 19 Disease Disease NNP cord-265799-qda5awuc 124 20 Control Control NNP cord-265799-qda5awuc 124 21 and and CC cord-265799-qda5awuc 124 22 Prevention Prevention NNP cord-265799-qda5awuc 124 23 . . . cord-265799-qda5awuc 125 1 Cases case NNS cord-265799-qda5awuc 125 2 in in IN cord-265799-qda5awuc 125 3 the the DT cord-265799-qda5awuc 125 4 U.S. U.S. NNP cord-265799-qda5awuc 125 5 Updated update VBN cord-265799-qda5awuc 125 6 Infectious Infectious NNP cord-265799-qda5awuc 125 7 Diseases Diseases NNPS cord-265799-qda5awuc 125 8 Society Society NNP cord-265799-qda5awuc 125 9 of of IN cord-265799-qda5awuc 125 10 America America NNP cord-265799-qda5awuc 125 11 Guidelines Guidelines NNPS cord-265799-qda5awuc 125 12 on on IN cord-265799-qda5awuc 125 13 the the DT cord-265799-qda5awuc 125 14 Treatment Treatment NNP cord-265799-qda5awuc 125 15 and and CC cord-265799-qda5awuc 125 16 Management Management NNP cord-265799-qda5awuc 125 17 of of IN cord-265799-qda5awuc 125 18 Patients Patients NNPS cord-265799-qda5awuc 125 19 with with IN cord-265799-qda5awuc 125 20 COVID-19 COVID-19 NNP cord-265799-qda5awuc 125 21 COVID-19 COVID-19 NNP cord-265799-qda5awuc 125 22 ) ) -RRB- cord-265799-qda5awuc 125 23 Treatment Treatment NNP cord-265799-qda5awuc 125 24 Guidelines Guidelines NNPS cord-265799-qda5awuc 125 25 . . . cord-265799-qda5awuc 126 1 National National NNP cord-265799-qda5awuc 126 2 Institutes Institutes NNPS cord-265799-qda5awuc 126 3 of of IN cord-265799-qda5awuc 126 4 Health Health NNP cord-265799-qda5awuc 126 5 Accessed access VBN cord-265799-qda5awuc 127 1 9/11/2020 9/11/2020 CD cord-265799-qda5awuc 127 2 Remdesivir Remdesivir NNP cord-265799-qda5awuc 127 3 and and CC cord-265799-qda5awuc 127 4 chloroquine chloroquine NN cord-265799-qda5awuc 127 5 effectively effectively RB cord-265799-qda5awuc 127 6 inhibit inhibit VBP cord-265799-qda5awuc 127 7 the the DT cord-265799-qda5awuc 127 8 recently recently RB cord-265799-qda5awuc 127 9 emerged emerge VBN cord-265799-qda5awuc 127 10 novel novel JJ cord-265799-qda5awuc 127 11 coronavirus coronavirus NN cord-265799-qda5awuc 127 12 ( ( -LRB- cord-265799-qda5awuc 127 13 2019-nCOV 2019-nCOV NNP cord-265799-qda5awuc 127 14 ) ) -RRB- cord-265799-qda5awuc 127 15 in in IN cord-265799-qda5awuc 127 16 vitro vitro FW cord-265799-qda5awuc 127 17 Remdesivir Remdesivir NNP cord-265799-qda5awuc 127 18 for for IN cord-265799-qda5awuc 127 19 the the DT cord-265799-qda5awuc 127 20 Treatment Treatment NNP cord-265799-qda5awuc 127 21 of of IN cord-265799-qda5awuc 127 22 Covid-19 Covid-19 NNP cord-265799-qda5awuc 127 23 -Preliminary -Preliminary NNP cord-265799-qda5awuc 127 24 Report Report NNP cord-265799-qda5awuc 127 25 Gilead Gilead NNP cord-265799-qda5awuc 127 26 Sciences Sciences NNPS cord-265799-qda5awuc 127 27 , , , cord-265799-qda5awuc 128 1 Inc. Inc. NNP cord-265799-qda5awuc 128 2 Fact Fact NNP cord-265799-qda5awuc 128 3 sheet sheet NN cord-265799-qda5awuc 128 4 for for IN cord-265799-qda5awuc 128 5 health health NN cord-265799-qda5awuc 128 6 care care NN cord-265799-qda5awuc 128 7 providers provider NNS cord-265799-qda5awuc 128 8 Emergency Emergency NNP cord-265799-qda5awuc 128 9 Use Use NNP cord-265799-qda5awuc 128 10 Authorization Authorization NNP cord-265799-qda5awuc 128 11 ( ( -LRB- cord-265799-qda5awuc 128 12 EUA EUA NNP cord-265799-qda5awuc 128 13 ) ) -RRB- cord-265799-qda5awuc 128 14 of of IN cord-265799-qda5awuc 128 15 Veklury Veklury NNP cord-265799-qda5awuc 128 16 ® ® . cord-265799-qda5awuc 128 17 ( ( -LRB- cord-265799-qda5awuc 128 18 remdesivir remdesivir NNP cord-265799-qda5awuc 128 19 ) ) -RRB- cord-265799-qda5awuc 129 1 Liver liver NN cord-265799-qda5awuc 129 2 injury injury NN cord-265799-qda5awuc 129 3 during during IN cord-265799-qda5awuc 129 4 highly highly RB cord-265799-qda5awuc 129 5 pathogenic pathogenic JJ cord-265799-qda5awuc 129 6 human human JJ cord-265799-qda5awuc 129 7 coronavirus coronavirus NN cord-265799-qda5awuc 129 8 infections infection NNS cord-265799-qda5awuc 129 9 Epidemiological epidemiological JJ cord-265799-qda5awuc 129 10 and and CC cord-265799-qda5awuc 129 11 clinical clinical JJ cord-265799-qda5awuc 129 12 characteristics characteristic NNS cord-265799-qda5awuc 129 13 of of IN cord-265799-qda5awuc 129 14 99 99 CD cord-265799-qda5awuc 129 15 cases case NNS cord-265799-qda5awuc 129 16 of of IN cord-265799-qda5awuc 129 17 2019 2019 CD cord-265799-qda5awuc 129 18 novel novel JJ cord-265799-qda5awuc 129 19 coronavirus coronavirus NN cord-265799-qda5awuc 129 20 pneumonia pneumonia NN cord-265799-qda5awuc 129 21 in in IN cord-265799-qda5awuc 129 22 Wuhan Wuhan NNP cord-265799-qda5awuc 129 23 , , , cord-265799-qda5awuc 129 24 China China NNP cord-265799-qda5awuc 129 25 : : : cord-265799-qda5awuc 130 1 a a DT cord-265799-qda5awuc 130 2 descriptive descriptive JJ cord-265799-qda5awuc 130 3 study study NN cord-265799-qda5awuc 130 4 Remdesivir Remdesivir NNP cord-265799-qda5awuc 130 5 for for IN cord-265799-qda5awuc 130 6 5 5 CD cord-265799-qda5awuc 130 7 or or CC cord-265799-qda5awuc 130 8 10 10 CD cord-265799-qda5awuc 130 9 Days day NNS cord-265799-qda5awuc 130 10 in in IN cord-265799-qda5awuc 130 11 Patients patient NNS cord-265799-qda5awuc 130 12 with with IN cord-265799-qda5awuc 130 13 Severe severe JJ cord-265799-qda5awuc 130 14 Covid-19 Covid-19 NNP cord-265799-qda5awuc 130 15 Drug Drug NNP cord-265799-qda5awuc 130 16 - - HYPH cord-265799-qda5awuc 130 17 induced induce VBN cord-265799-qda5awuc 130 18 liver liver NN cord-265799-qda5awuc 130 19 injury injury NN cord-265799-qda5awuc 130 20 in in IN cord-265799-qda5awuc 130 21 a a DT cord-265799-qda5awuc 130 22 COVID-19 covid-19 JJ cord-265799-qda5awuc 130 23 patient patient NN cord-265799-qda5awuc 130 24 : : : cord-265799-qda5awuc 130 25 potential potential JJ cord-265799-qda5awuc 130 26 interaction interaction NN cord-265799-qda5awuc 130 27 of of IN cord-265799-qda5awuc 130 28 remdesivir remdesivir NNP cord-265799-qda5awuc 130 29 with with IN cord-265799-qda5awuc 130 30 P p NN cord-265799-qda5awuc 130 31 - - HYPH cord-265799-qda5awuc 130 32 glycoprotein glycoprotein NN cord-265799-qda5awuc 130 33 inhibitors inhibitor NNS cord-265799-qda5awuc 131 1 A a DT cord-265799-qda5awuc 131 2 method method NN cord-265799-qda5awuc 131 3 for for IN cord-265799-qda5awuc 131 4 estimated estimate VBN cord-265799-qda5awuc 131 5 the the DT cord-265799-qda5awuc 131 6 probability probability NN cord-265799-qda5awuc 131 7 of of IN cord-265799-qda5awuc 131 8 adverse adverse JJ cord-265799-qda5awuc 131 9 drug drug NN cord-265799-qda5awuc 131 10 reactions reaction NNS cord-265799-qda5awuc 131 11 Wolters Wolters NNP cord-265799-qda5awuc 131 12 Kluwer Kluwer NNP cord-265799-qda5awuc 131 13 Health Health NNP cord-265799-qda5awuc 131 14 LiverTox LiverTox NNP cord-265799-qda5awuc 131 15 : : : cord-265799-qda5awuc 132 1 Clinical clinical JJ cord-265799-qda5awuc 132 2 and and CC cord-265799-qda5awuc 132 3 Research Research NNP cord-265799-qda5awuc 132 4 Information Information NNP cord-265799-qda5awuc 132 5 on on IN cord-265799-qda5awuc 132 6 Drug Drug NNP cord-265799-qda5awuc 132 7 - - HYPH cord-265799-qda5awuc 132 8 Induced Induced NNP cord-265799-qda5awuc 132 9 Liver Liver NNP cord-265799-qda5awuc 132 10 Injury Injury NNP cord-265799-qda5awuc 132 11 National National NNP cord-265799-qda5awuc 132 12 Institute Institute NNP cord-265799-qda5awuc 132 13 of of IN cord-265799-qda5awuc 132 14 Diabetes Diabetes NNP cord-265799-qda5awuc 132 15 and and CC cord-265799-qda5awuc 132 16 Digestive digestive JJ cord-265799-qda5awuc 132 17 and and CC cord-265799-qda5awuc 132 18 Kidney Kidney NNP cord-265799-qda5awuc 132 19 Diseases Diseases NNPS cord-265799-qda5awuc 132 20 ; ; : cord-265799-qda5awuc 132 21 2012- 2012- NNP cord-265799-qda5awuc 132 22 . . . cord-265799-qda5awuc 133 1 Tocilizumab tocilizumab JJ cord-265799-qda5awuc 133 2 AASLD AASLD NNP cord-265799-qda5awuc 133 3 Position Position NNP cord-265799-qda5awuc 133 4 Paper Paper NNP cord-265799-qda5awuc 133 5 : : : cord-265799-qda5awuc 134 1 The the DT cord-265799-qda5awuc 134 2 Management Management NNP cord-265799-qda5awuc 134 3 of of IN cord-265799-qda5awuc 134 4 Acute Acute NNP cord-265799-qda5awuc 134 5 Liver Liver NNP cord-265799-qda5awuc 134 6 Failure failure NN cord-265799-qda5awuc 134 7 : : : cord-265799-qda5awuc 134 8 Update update VB cord-265799-qda5awuc 134 9 European European NNP cord-265799-qda5awuc 134 10 Association Association NNP cord-265799-qda5awuc 134 11 for for IN cord-265799-qda5awuc 134 12 the the DT cord-265799-qda5awuc 134 13 Study Study NNP cord-265799-qda5awuc 134 14 of of IN cord-265799-qda5awuc 134 15 the the DT cord-265799-qda5awuc 134 16 Liver liver NN cord-265799-qda5awuc 134 17 . . . cord-265799-qda5awuc 135 1 EASL EASL NNP cord-265799-qda5awuc 135 2 Clinical Clinical NNP cord-265799-qda5awuc 135 3 Practical Practical NNP cord-265799-qda5awuc 135 4 Guidelines Guidelines NNPS cord-265799-qda5awuc 135 5 on on IN cord-265799-qda5awuc 135 6 the the DT cord-265799-qda5awuc 135 7 management management NN cord-265799-qda5awuc 135 8 of of IN cord-265799-qda5awuc 135 9 acute acute JJ cord-265799-qda5awuc 135 10 ( ( -LRB- cord-265799-qda5awuc 135 11 fulminant fulminant JJ cord-265799-qda5awuc 135 12 ) ) -RRB- cord-265799-qda5awuc 135 13 liver liver NN cord-265799-qda5awuc 135 14 failure failure NN cord-265799-qda5awuc 135 15 American American NNP cord-265799-qda5awuc 135 16 Gastroenterological Gastroenterological NNP cord-265799-qda5awuc 135 17 Association Association NNP cord-265799-qda5awuc 135 18 Institute Institute NNP cord-265799-qda5awuc 135 19 Guidelines Guidelines NNPS cord-265799-qda5awuc 135 20 for for IN cord-265799-qda5awuc 135 21 the the DT cord-265799-qda5awuc 135 22 Diagnosis Diagnosis NNP cord-265799-qda5awuc 135 23 and and CC cord-265799-qda5awuc 135 24 Management Management NNP cord-265799-qda5awuc 135 25 of of IN cord-265799-qda5awuc 135 26 Acute Acute NNP cord-265799-qda5awuc 135 27 Liver Liver NNP cord-265799-qda5awuc 135 28 Failure failure NN cord-265799-qda5awuc 135 29 Use use NN cord-265799-qda5awuc 135 30 of of IN cord-265799-qda5awuc 135 31 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 135 32 for for IN cord-265799-qda5awuc 135 33 non non JJ cord-265799-qda5awuc 135 34 - - JJ cord-265799-qda5awuc 135 35 acetaminophen acetaminophen JJ cord-265799-qda5awuc 135 36 - - HYPH cord-265799-qda5awuc 135 37 induced induce VBN cord-265799-qda5awuc 135 38 acute acute JJ cord-265799-qda5awuc 135 39 liver liver NN cord-265799-qda5awuc 135 40 failure failure NN cord-265799-qda5awuc 136 1 Intravenous Intravenous NNP cord-265799-qda5awuc 136 2 N n NN cord-265799-qda5awuc 136 3 - - HYPH cord-265799-qda5awuc 136 4 Acetylcysteine Acetylcysteine NNP cord-265799-qda5awuc 136 5 Improves improve VBZ cord-265799-qda5awuc 136 6 Transplant Transplant NNP cord-265799-qda5awuc 136 7 - - HYPH cord-265799-qda5awuc 136 8 Free Free NNP cord-265799-qda5awuc 136 9 Survival Survival NNP cord-265799-qda5awuc 136 10 in in IN cord-265799-qda5awuc 136 11 Early early JJ cord-265799-qda5awuc 136 12 Stage stage NN cord-265799-qda5awuc 136 13 Non Non NNP cord-265799-qda5awuc 136 14 - - JJ cord-265799-qda5awuc 136 15 Acetaminophen acetaminophen JJ cord-265799-qda5awuc 136 16 Acute acute JJ cord-265799-qda5awuc 136 17 Liver Liver NNP cord-265799-qda5awuc 136 18 Failure failure NN cord-265799-qda5awuc 136 19 Role role NN cord-265799-qda5awuc 136 20 of of IN cord-265799-qda5awuc 136 21 N n NN cord-265799-qda5awuc 136 22 - - HYPH cord-265799-qda5awuc 136 23 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 136 24 in in IN cord-265799-qda5awuc 136 25 adults adult NNS cord-265799-qda5awuc 136 26 with with IN cord-265799-qda5awuc 136 27 non non JJ cord-265799-qda5awuc 136 28 - - JJ cord-265799-qda5awuc 136 29 acetaminopheninduced acetaminopheninduced JJ cord-265799-qda5awuc 136 30 acute acute JJ cord-265799-qda5awuc 136 31 liver liver NN cord-265799-qda5awuc 136 32 failure failure NN cord-265799-qda5awuc 136 33 in in IN cord-265799-qda5awuc 136 34 a a DT cord-265799-qda5awuc 136 35 center center NN cord-265799-qda5awuc 136 36 without without IN cord-265799-qda5awuc 136 37 the the DT cord-265799-qda5awuc 136 38 facility facility NN cord-265799-qda5awuc 136 39 of of IN cord-265799-qda5awuc 136 40 liver liver NN cord-265799-qda5awuc 136 41 transplantation transplantation NN cord-265799-qda5awuc 136 42 Effect Effect NNP cord-265799-qda5awuc 136 43 of of IN cord-265799-qda5awuc 136 44 N N NNP cord-265799-qda5awuc 136 45 - - HYPH cord-265799-qda5awuc 136 46 Acetylcysteine Acetylcysteine NNP cord-265799-qda5awuc 136 47 on on IN cord-265799-qda5awuc 136 48 Mortality mortality NN cord-265799-qda5awuc 136 49 and and CC cord-265799-qda5awuc 136 50 Liver Liver NNP cord-265799-qda5awuc 136 51 Transplantation transplantation NN cord-265799-qda5awuc 136 52 Rate rate NN cord-265799-qda5awuc 136 53 in in IN cord-265799-qda5awuc 136 54 Non non JJ cord-265799-qda5awuc 136 55 - - JJ cord-265799-qda5awuc 136 56 Acetaminophen acetaminophen JJ cord-265799-qda5awuc 136 57 - - HYPH cord-265799-qda5awuc 136 58 Induced induce VBN cord-265799-qda5awuc 136 59 Acute Acute NNP cord-265799-qda5awuc 136 60 Liver Liver NNP cord-265799-qda5awuc 136 61 Failure failure NN cord-265799-qda5awuc 136 62 : : : cord-265799-qda5awuc 136 63 A a DT cord-265799-qda5awuc 136 64 Multicenter Multicenter NNP cord-265799-qda5awuc 136 65 Study Study NNP cord-265799-qda5awuc 137 1 The the DT cord-265799-qda5awuc 137 2 use use NN cord-265799-qda5awuc 137 3 of of IN cord-265799-qda5awuc 137 4 the the DT cord-265799-qda5awuc 137 5 novel novel JJ cord-265799-qda5awuc 137 6 antiviral antiviral JJ cord-265799-qda5awuc 137 7 remdesivir remdesivir NNS cord-265799-qda5awuc 137 8 in in IN cord-265799-qda5awuc 137 9 the the DT cord-265799-qda5awuc 137 10 treatment treatment NN cord-265799-qda5awuc 137 11 of of IN cord-265799-qda5awuc 137 12 COVID-19 COVID-19 NNP cord-265799-qda5awuc 137 13 pneumonia pneumonia NN cord-265799-qda5awuc 137 14 may may MD cord-265799-qda5awuc 137 15 put put VB cord-265799-qda5awuc 137 16 patients patient NNS cord-265799-qda5awuc 137 17 at at IN cord-265799-qda5awuc 137 18 risk risk NN cord-265799-qda5awuc 137 19 of of IN cord-265799-qda5awuc 137 20 drug drug NN cord-265799-qda5awuc 137 21 - - HYPH cord-265799-qda5awuc 137 22 associated associate VBN cord-265799-qda5awuc 137 23 acute acute JJ cord-265799-qda5awuc 137 24 liver liver NN cord-265799-qda5awuc 137 25 failure failure NN cord-265799-qda5awuc 137 26 . . . cord-265799-qda5awuc 138 1 In in IN cord-265799-qda5awuc 138 2 the the DT cord-265799-qda5awuc 138 3 two two CD cord-265799-qda5awuc 138 4 cases case NNS cord-265799-qda5awuc 138 5 presented present VBN cord-265799-qda5awuc 138 6 , , , cord-265799-qda5awuc 138 7 the the DT cord-265799-qda5awuc 138 8 liver liver NN cord-265799-qda5awuc 138 9 failure failure NN cord-265799-qda5awuc 138 10 experienced experience VBD cord-265799-qda5awuc 138 11 improved improve VBD cord-265799-qda5awuc 138 12 with with IN cord-265799-qda5awuc 138 13 the the DT cord-265799-qda5awuc 138 14 administration administration NN cord-265799-qda5awuc 138 15 of of IN cord-265799-qda5awuc 138 16 acetylcysteine acetylcysteine NNP cord-265799-qda5awuc 138 17 and and CC cord-265799-qda5awuc 138 18 discontinuation discontinuation NN cord-265799-qda5awuc 138 19 of of IN cord-265799-qda5awuc 138 20 potentially potentially RB cord-265799-qda5awuc 138 21 hepatotoxic hepatotoxic JJ cord-265799-qda5awuc 138 22 medications medication NNS cord-265799-qda5awuc 138 23 . . . cord-265799-qda5awuc 139 1 More More JJR cord-265799-qda5awuc 139 2 data datum NNS cord-265799-qda5awuc 139 3 on on IN cord-265799-qda5awuc 139 4 the the DT cord-265799-qda5awuc 139 5 risk risk NN cord-265799-qda5awuc 139 6 of of IN cord-265799-qda5awuc 139 7 remdesivir remdesivir NNP cord-265799-qda5awuc 139 8 - - HYPH cord-265799-qda5awuc 139 9 associated associate VBN cord-265799-qda5awuc 139 10 acute acute JJ cord-265799-qda5awuc 139 11 liver liver NN cord-265799-qda5awuc 139 12 failure failure NN cord-265799-qda5awuc 139 13 and and CC cord-265799-qda5awuc 139 14 its -PRON- PRP$ cord-265799-qda5awuc 139 15 management management NN cord-265799-qda5awuc 139 16 with with IN cord-265799-qda5awuc 139 17 acetylcysteine acetylcysteine NN cord-265799-qda5awuc 139 18 is be VBZ cord-265799-qda5awuc 139 19 needed need VBN cord-265799-qda5awuc 139 20 . . .