id sid tid token lemma pos cord-263267-oj7rmy8m 1 1 key key NN cord-263267-oj7rmy8m 1 2 : : : cord-263267-oj7rmy8m 2 1 cord-263267-oj7rmy8 cord-263267-oj7rmy8 NNP cord-263267-oj7rmy8m 2 2 m m NNP cord-263267-oj7rmy8m 2 3 authors author NNS cord-263267-oj7rmy8m 2 4 : : : cord-263267-oj7rmy8m 2 5 Taccone Taccone NNP cord-263267-oj7rmy8m 2 6 , , , cord-263267-oj7rmy8m 2 7 Fabio Fabio NNP cord-263267-oj7rmy8m 2 8 S S NNP cord-263267-oj7rmy8m 2 9 ; ; : cord-263267-oj7rmy8m 2 10 Gorham Gorham NNP cord-263267-oj7rmy8m 2 11 , , , cord-263267-oj7rmy8m 2 12 Julie Julie NNP cord-263267-oj7rmy8m 2 13 ; ; : cord-263267-oj7rmy8m 2 14 Vincent Vincent NNP cord-263267-oj7rmy8m 2 15 , , , cord-263267-oj7rmy8m 2 16 Jean Jean NNP cord-263267-oj7rmy8m 2 17 - - HYPH cord-263267-oj7rmy8m 2 18 Louis Louis NNP cord-263267-oj7rmy8m 2 19 title title NN cord-263267-oj7rmy8m 2 20 : : : cord-263267-oj7rmy8m 2 21 Hydroxychloroquine Hydroxychloroquine NNP cord-263267-oj7rmy8m 2 22 in in IN cord-263267-oj7rmy8m 2 23 the the DT cord-263267-oj7rmy8m 2 24 management management NN cord-263267-oj7rmy8m 2 25 of of IN cord-263267-oj7rmy8m 2 26 critically critically RB cord-263267-oj7rmy8m 2 27 ill ill JJ cord-263267-oj7rmy8m 2 28 patients patient NNS cord-263267-oj7rmy8m 2 29 with with IN cord-263267-oj7rmy8m 2 30 COVID-19 covid-19 VB cord-263267-oj7rmy8m 2 31 : : : cord-263267-oj7rmy8m 2 32 the the DT cord-263267-oj7rmy8m 2 33 need need NN cord-263267-oj7rmy8m 2 34 for for IN cord-263267-oj7rmy8m 2 35 an an DT cord-263267-oj7rmy8m 2 36 evidence evidence NN cord-263267-oj7rmy8m 2 37 base base NN cord-263267-oj7rmy8m 2 38 date date NN cord-263267-oj7rmy8m 2 39 : : : cord-263267-oj7rmy8m 2 40 2020 2020 CD cord-263267-oj7rmy8m 2 41 - - HYPH cord-263267-oj7rmy8m 2 42 04 04 CD cord-263267-oj7rmy8m 2 43 - - SYM cord-263267-oj7rmy8m 2 44 15 15 CD cord-263267-oj7rmy8m 2 45 journal journal NN cord-263267-oj7rmy8m 2 46 : : : cord-263267-oj7rmy8m 2 47 Lancet Lancet NNP cord-263267-oj7rmy8m 2 48 Respir Respir NNP cord-263267-oj7rmy8m 2 49 Med Med NNP cord-263267-oj7rmy8m 2 50 DOI doi NN cord-263267-oj7rmy8m 2 51 : : : cord-263267-oj7rmy8m 2 52 10.1016 10.1016 CD cord-263267-oj7rmy8m 2 53 / / SYM cord-263267-oj7rmy8m 2 54 s2213 s2213 NN cord-263267-oj7rmy8m 2 55 - - HYPH cord-263267-oj7rmy8m 2 56 2600(20)30172 2600(20)30172 CD cord-263267-oj7rmy8m 2 57 - - HYPH cord-263267-oj7rmy8m 2 58 7 7 CD cord-263267-oj7rmy8m 2 59 sha sha NN cord-263267-oj7rmy8m 2 60 : : : cord-263267-oj7rmy8m 3 1 cfef8928ebc57961e1a604a099878dc839434688 cfef8928ebc57961e1a604a099878dc839434688 NNP cord-263267-oj7rmy8m 3 2 doc_id doc_id CD cord-263267-oj7rmy8m 3 3 : : : cord-263267-oj7rmy8m 3 4 263267 263267 CD cord-263267-oj7rmy8m 3 5 cord_uid cord_uid NNS cord-263267-oj7rmy8m 3 6 : : : cord-263267-oj7rmy8m 4 1 oj7rmy8 oj7rmy8 NNP cord-263267-oj7rmy8m 5 1 m m NNP cord-263267-oj7rmy8m 5 2 nan nan NNP cord-263267-oj7rmy8m 6 1 With with IN cord-263267-oj7rmy8m 6 2 the the DT cord-263267-oj7rmy8m 6 3 rapid rapid JJ cord-263267-oj7rmy8m 6 4 spread spread NN cord-263267-oj7rmy8m 6 5 of of IN cord-263267-oj7rmy8m 6 6 the the DT cord-263267-oj7rmy8m 6 7 novel novel JJ cord-263267-oj7rmy8m 6 8 severe severe JJ cord-263267-oj7rmy8m 6 9 acute acute JJ cord-263267-oj7rmy8m 6 10 respiratory respiratory JJ cord-263267-oj7rmy8m 6 11 syndrome syndrome NN cord-263267-oj7rmy8m 6 12 coronavirus coronavirus NN cord-263267-oj7rmy8m 6 13 2 2 CD cord-263267-oj7rmy8m 6 14 ( ( -LRB- cord-263267-oj7rmy8m 6 15 SARS SARS NNP cord-263267-oj7rmy8m 6 16 - - HYPH cord-263267-oj7rmy8m 6 17 CoV-2 CoV-2 NNP cord-263267-oj7rmy8m 6 18 ) ) -RRB- cord-263267-oj7rmy8m 6 19 , , , cord-263267-oj7rmy8m 6 20 critical critical JJ cord-263267-oj7rmy8m 6 21 care care NN cord-263267-oj7rmy8m 6 22 physicians physician NNS cord-263267-oj7rmy8m 6 23 are be VBP cord-263267-oj7rmy8m 6 24 seeing see VBG cord-263267-oj7rmy8m 6 25 increasing increase VBG cord-263267-oj7rmy8m 6 26 numbers number NNS cord-263267-oj7rmy8m 6 27 of of IN cord-263267-oj7rmy8m 6 28 patients patient NNS cord-263267-oj7rmy8m 6 29 with with IN cord-263267-oj7rmy8m 6 30 acute acute JJ cord-263267-oj7rmy8m 6 31 respiratory respiratory JJ cord-263267-oj7rmy8m 6 32 failure failure NN cord-263267-oj7rmy8m 6 33 secondary secondary JJ cord-263267-oj7rmy8m 6 34 to to IN cord-263267-oj7rmy8m 6 35 coronavirus coronavirus NN cord-263267-oj7rmy8m 6 36 disease disease NN cord-263267-oj7rmy8m 6 37 2019 2019 CD cord-263267-oj7rmy8m 6 38 ( ( -LRB- cord-263267-oj7rmy8m 6 39 COVID-19 COVID-19 NNP cord-263267-oj7rmy8m 6 40 ) ) -RRB- cord-263267-oj7rmy8m 6 41 and and CC cord-263267-oj7rmy8m 6 42 reporting report VBG cord-263267-oj7rmy8m 6 43 mortality mortality NN cord-263267-oj7rmy8m 6 44 rates rate NNS cord-263267-oj7rmy8m 6 45 of of IN cord-263267-oj7rmy8m 6 46 40 40 CD cord-263267-oj7rmy8m 6 47 - - SYM cord-263267-oj7rmy8m 6 48 65 65 CD cord-263267-oj7rmy8m 6 49 % % NN cord-263267-oj7rmy8m 6 50 for for IN cord-263267-oj7rmy8m 6 51 those those DT cord-263267-oj7rmy8m 6 52 requiring require VBG cord-263267-oj7rmy8m 6 53 mechanical mechanical JJ cord-263267-oj7rmy8m 6 54 ventilation ventilation NN cord-263267-oj7rmy8m 6 55 1 1 CD cord-263267-oj7rmy8m 6 56 -strikingly -strikingly RB cord-263267-oj7rmy8m 6 57 higher high JJR cord-263267-oj7rmy8m 6 58 than than IN cord-263267-oj7rmy8m 6 59 the the DT cord-263267-oj7rmy8m 6 60 mortality mortality NN cord-263267-oj7rmy8m 6 61 rates rate NNS cord-263267-oj7rmy8m 6 62 reported report VBN cord-263267-oj7rmy8m 6 63 for for IN cord-263267-oj7rmy8m 6 64 the the DT cord-263267-oj7rmy8m 6 65 more more RBR cord-263267-oj7rmy8m 6 66 typical typical JJ cord-263267-oj7rmy8m 6 67 acute acute JJ cord-263267-oj7rmy8m 6 68 respiratory respiratory JJ cord-263267-oj7rmy8m 6 69 distress distress NN cord-263267-oj7rmy8m 6 70 syndrome syndrome NN cord-263267-oj7rmy8m 6 71 associated associate VBN cord-263267-oj7rmy8m 6 72 with with IN cord-263267-oj7rmy8m 6 73 other other JJ cord-263267-oj7rmy8m 6 74 diseases disease NNS cord-263267-oj7rmy8m 6 75 . . . cord-263267-oj7rmy8m 7 1 2 2 LS cord-263267-oj7rmy8m 8 1 The the DT cord-263267-oj7rmy8m 8 2 focus focus NN cord-263267-oj7rmy8m 8 3 of of IN cord-263267-oj7rmy8m 8 4 therapeutic therapeutic JJ cord-263267-oj7rmy8m 8 5 intervention intervention NN cord-263267-oj7rmy8m 8 6 has have VBZ cord-263267-oj7rmy8m 8 7 therefore therefore RB cord-263267-oj7rmy8m 8 8 been be VBN cord-263267-oj7rmy8m 8 9 not not RB cord-263267-oj7rmy8m 8 10 only only RB cord-263267-oj7rmy8m 8 11 to to TO cord-263267-oj7rmy8m 8 12 reverse reverse VB cord-263267-oj7rmy8m 8 13 hypoxaemia hypoxaemia NN cord-263267-oj7rmy8m 8 14 and and CC cord-263267-oj7rmy8m 8 15 provide provide VB cord-263267-oj7rmy8m 8 16 adequate adequate JJ cord-263267-oj7rmy8m 8 17 organ organ NN cord-263267-oj7rmy8m 8 18 support support NN cord-263267-oj7rmy8m 8 19 , , , cord-263267-oj7rmy8m 8 20 but but CC cord-263267-oj7rmy8m 8 21 also also RB cord-263267-oj7rmy8m 8 22 to to TO cord-263267-oj7rmy8m 8 23 decrease decrease VB cord-263267-oj7rmy8m 8 24 viral viral JJ cord-263267-oj7rmy8m 8 25 load load NN cord-263267-oj7rmy8m 8 26 and and CC cord-263267-oj7rmy8m 8 27 thus thus RB cord-263267-oj7rmy8m 8 28 limit limit VB cord-263267-oj7rmy8m 8 29 disease disease NN cord-263267-oj7rmy8m 8 30 severity severity NN cord-263267-oj7rmy8m 8 31 . . . cord-263267-oj7rmy8m 9 1 In in IN cord-263267-oj7rmy8m 9 2 addition addition NN cord-263267-oj7rmy8m 9 3 to to IN cord-263267-oj7rmy8m 9 4 several several JJ cord-263267-oj7rmy8m 9 5 antiviral antiviral JJ cord-263267-oj7rmy8m 9 6 agents agent NNS cord-263267-oj7rmy8m 9 7 , , , cord-263267-oj7rmy8m 9 8 antimalarial antimalarial JJ cord-263267-oj7rmy8m 9 9 drugs drug NNS cord-263267-oj7rmy8m 9 10 have have VBP cord-263267-oj7rmy8m 9 11 been be VBN cord-263267-oj7rmy8m 9 12 proposed propose VBN cord-263267-oj7rmy8m 9 13 as as IN cord-263267-oj7rmy8m 9 14 treatments treatment NNS cord-263267-oj7rmy8m 9 15 that that WDT cord-263267-oj7rmy8m 9 16 could could MD cord-263267-oj7rmy8m 9 17 reduce reduce VB cord-263267-oj7rmy8m 9 18 transmission transmission NN cord-263267-oj7rmy8m 9 19 of of IN cord-263267-oj7rmy8m 9 20 the the DT cord-263267-oj7rmy8m 9 21 virus virus NN cord-263267-oj7rmy8m 9 22 . . . cord-263267-oj7rmy8m 10 1 In in IN cord-263267-oj7rmy8m 10 2 - - HYPH cord-263267-oj7rmy8m 10 3 vitro vitro FW cord-263267-oj7rmy8m 10 4 studies study NNS cord-263267-oj7rmy8m 10 5 have have VBP cord-263267-oj7rmy8m 10 6 shown show VBN cord-263267-oj7rmy8m 10 7 that that IN cord-263267-oj7rmy8m 10 8 chloroquine chloroquine NN cord-263267-oj7rmy8m 10 9 and and CC cord-263267-oj7rmy8m 10 10 hydroxychloroquine hydroxychloroquine NN cord-263267-oj7rmy8m 10 11 can can MD cord-263267-oj7rmy8m 10 12 both both CC cord-263267-oj7rmy8m 10 13 inhibit inhibit VB cord-263267-oj7rmy8m 10 14 SARS SARS NNP cord-263267-oj7rmy8m 10 15 - - HYPH cord-263267-oj7rmy8m 10 16 CoV-2 CoV-2 NNP cord-263267-oj7rmy8m 10 17 transmission transmission NN cord-263267-oj7rmy8m 10 18 , , , cord-263267-oj7rmy8m 10 19 3 3 CD cord-263267-oj7rmy8m 10 20 - - SYM cord-263267-oj7rmy8m 10 21 5 5 CD cord-263267-oj7rmy8m 10 22 through through IN cord-263267-oj7rmy8m 10 23 alkalinisation alkalinisation NN cord-263267-oj7rmy8m 10 24 of of IN cord-263267-oj7rmy8m 10 25 the the DT cord-263267-oj7rmy8m 10 26 intracellular intracellular JJ cord-263267-oj7rmy8m 10 27 phagolysosome phagolysosome NN cord-263267-oj7rmy8m 10 28 , , , cord-263267-oj7rmy8m 10 29 which which WDT cord-263267-oj7rmy8m 10 30 prevents prevent VBZ cord-263267-oj7rmy8m 10 31 virion virion NN cord-263267-oj7rmy8m 10 32 fusion fusion NN cord-263267-oj7rmy8m 10 33 and and CC cord-263267-oj7rmy8m 10 34 uncoating uncoating NN cord-263267-oj7rmy8m 10 35 and and CC cord-263267-oj7rmy8m 10 36 , , , cord-263267-oj7rmy8m 10 37 therefore therefore RB cord-263267-oj7rmy8m 10 38 , , , cord-263267-oj7rmy8m 10 39 viral viral JJ cord-263267-oj7rmy8m 10 40 spread spread NN cord-263267-oj7rmy8m 10 41 . . . cord-263267-oj7rmy8m 11 1 Early early JJ cord-263267-oj7rmy8m 11 2 results result NNS cord-263267-oj7rmy8m 11 3 from from IN cord-263267-oj7rmy8m 11 4 clinical clinical JJ cord-263267-oj7rmy8m 11 5 studies study NNS cord-263267-oj7rmy8m 11 6 conducted conduct VBN cord-263267-oj7rmy8m 11 7 in in IN cord-263267-oj7rmy8m 11 8 China China NNP cord-263267-oj7rmy8m 11 9 suggest suggest VBP cord-263267-oj7rmy8m 11 10 that that IN cord-263267-oj7rmy8m 11 11 chloroquine chloroquine NN cord-263267-oj7rmy8m 11 12 use use NN cord-263267-oj7rmy8m 11 13 might may MD cord-263267-oj7rmy8m 11 14 have have VB cord-263267-oj7rmy8m 11 15 been be VBN cord-263267-oj7rmy8m 11 16 associated associate VBN cord-263267-oj7rmy8m 11 17 with with IN cord-263267-oj7rmy8m 11 18 reduced reduce VBN cord-263267-oj7rmy8m 11 19 fever fever NN cord-263267-oj7rmy8m 11 20 , , , cord-263267-oj7rmy8m 11 21 increased increase VBN cord-263267-oj7rmy8m 11 22 resolution resolution NN cord-263267-oj7rmy8m 11 23 of of IN cord-263267-oj7rmy8m 11 24 lung lung NN cord-263267-oj7rmy8m 11 25 lesions lesion NNS cord-263267-oj7rmy8m 11 26 on on IN cord-263267-oj7rmy8m 11 27 CT CT NNP cord-263267-oj7rmy8m 11 28 , , , cord-263267-oj7rmy8m 11 29 and and CC cord-263267-oj7rmy8m 11 30 delayed delay VBN cord-263267-oj7rmy8m 11 31 disease disease NN cord-263267-oj7rmy8m 11 32 progression progression NN cord-263267-oj7rmy8m 11 33 . . . cord-263267-oj7rmy8m 12 1 6,7 6,7 CD cord-263267-oj7rmy8m 12 2 Results result NNS cord-263267-oj7rmy8m 12 3 of of IN cord-263267-oj7rmy8m 12 4 two two CD cord-263267-oj7rmy8m 12 5 French french JJ cord-263267-oj7rmy8m 12 6 studies study NNS cord-263267-oj7rmy8m 12 7 suggested suggest VBD cord-263267-oj7rmy8m 12 8 that that IN cord-263267-oj7rmy8m 12 9 hydroxychloroquine hydroxychloroquine NNP cord-263267-oj7rmy8m 12 10 could could MD cord-263267-oj7rmy8m 12 11 reduce reduce VB cord-263267-oj7rmy8m 12 12 the the DT cord-263267-oj7rmy8m 12 13 viral viral JJ cord-263267-oj7rmy8m 12 14 load load NN cord-263267-oj7rmy8m 12 15 in in IN cord-263267-oj7rmy8m 12 16 patients patient NNS cord-263267-oj7rmy8m 12 17 with with IN cord-263267-oj7rmy8m 12 18 COVID-19 COVID-19 NNP cord-263267-oj7rmy8m 12 19 in in IN cord-263267-oj7rmy8m 12 20 particular particular JJ cord-263267-oj7rmy8m 12 21 , , , cord-263267-oj7rmy8m 12 22 if if IN cord-263267-oj7rmy8m 12 23 combined combine VBN cord-263267-oj7rmy8m 12 24 with with IN cord-263267-oj7rmy8m 12 25 azithromycin azithromycin NNP cord-263267-oj7rmy8m 12 26 8,9 8,9 CD cord-263267-oj7rmy8m 12 27 ( ( -LRB- cord-263267-oj7rmy8m 12 28 table table NN cord-263267-oj7rmy8m 12 29 ) ) -RRB- cord-263267-oj7rmy8m 12 30 . . . cord-263267-oj7rmy8m 13 1 On on IN cord-263267-oj7rmy8m 13 2 the the DT cord-263267-oj7rmy8m 13 3 basis basis NN cord-263267-oj7rmy8m 13 4 of of IN cord-263267-oj7rmy8m 13 5 these these DT cord-263267-oj7rmy8m 13 6 preliminary preliminary JJ cord-263267-oj7rmy8m 13 7 findings finding NNS cord-263267-oj7rmy8m 13 8 , , , cord-263267-oj7rmy8m 13 9 chloroquine chloroquine NN cord-263267-oj7rmy8m 13 10 and and CC cord-263267-oj7rmy8m 13 11 hydroxychloroquine hydroxychloroquine NN cord-263267-oj7rmy8m 13 12 have have VBP cord-263267-oj7rmy8m 13 13 been be VBN cord-263267-oj7rmy8m 13 14 prescribed prescribe VBN cord-263267-oj7rmy8m 13 15 to to IN cord-263267-oj7rmy8m 13 16 patients patient NNS cord-263267-oj7rmy8m 13 17 to to TO cord-263267-oj7rmy8m 13 18 reduce reduce VB cord-263267-oj7rmy8m 13 19 the the DT cord-263267-oj7rmy8m 13 20 length length NN cord-263267-oj7rmy8m 13 21 of of IN cord-263267-oj7rmy8m 13 22 hospital hospital NN cord-263267-oj7rmy8m 13 23 stay stay NN cord-263267-oj7rmy8m 13 24 and and CC cord-263267-oj7rmy8m 13 25 improve improve VB cord-263267-oj7rmy8m 13 26 the the DT cord-263267-oj7rmy8m 13 27 evolution evolution NN cord-263267-oj7rmy8m 13 28 of of IN cord-263267-oj7rmy8m 13 29 COVID-19-related covid-19-related JJ cord-263267-oj7rmy8m 13 30 pneumonia pneumonia NN cord-263267-oj7rmy8m 13 31 . . . cord-263267-oj7rmy8m 14 1 Nevertheless nevertheless RB cord-263267-oj7rmy8m 14 2 , , , cord-263267-oj7rmy8m 14 3 the the DT cord-263267-oj7rmy8m 14 4 recently recently RB cord-263267-oj7rmy8m 14 5 published publish VBN cord-263267-oj7rmy8m 14 6 Surviving Surviving NNP cord-263267-oj7rmy8m 14 7 Sepsis Sepsis NNP cord-263267-oj7rmy8m 14 8 Campaign Campaign NNP cord-263267-oj7rmy8m 14 9 guidelines guideline NNS cord-263267-oj7rmy8m 14 10 on on IN cord-263267-oj7rmy8m 14 11 the the DT cord-263267-oj7rmy8m 14 12 management management NN cord-263267-oj7rmy8m 14 13 of of IN cord-263267-oj7rmy8m 14 14 critically critically RB cord-263267-oj7rmy8m 14 15 ill ill JJ cord-263267-oj7rmy8m 14 16 patients patient NNS cord-263267-oj7rmy8m 14 17 with with IN cord-263267-oj7rmy8m 14 18 COVID-19 COVID-19 NNP cord-263267-oj7rmy8m 14 19 concluded conclude VBD cord-263267-oj7rmy8m 14 20 that that IN cord-263267-oj7rmy8m 14 21 there there EX cord-263267-oj7rmy8m 14 22 was be VBD cord-263267-oj7rmy8m 14 23 insufficient insufficient JJ cord-263267-oj7rmy8m 14 24 evidence evidence NN cord-263267-oj7rmy8m 14 25 to to TO cord-263267-oj7rmy8m 14 26 offer offer VB cord-263267-oj7rmy8m 14 27 any any DT cord-263267-oj7rmy8m 14 28 recommendation recommendation NN cord-263267-oj7rmy8m 14 29 on on IN cord-263267-oj7rmy8m 14 30 the the DT cord-263267-oj7rmy8m 14 31 routine routine JJ cord-263267-oj7rmy8m 14 32 use use NN cord-263267-oj7rmy8m 14 33 of of IN cord-263267-oj7rmy8m 14 34 these these DT cord-263267-oj7rmy8m 14 35 drugs drug NNS cord-263267-oj7rmy8m 14 36 in in IN cord-263267-oj7rmy8m 14 37 patients patient NNS cord-263267-oj7rmy8m 14 38 admitted admit VBN cord-263267-oj7rmy8m 14 39 to to IN cord-263267-oj7rmy8m 14 40 the the DT cord-263267-oj7rmy8m 14 41 intensive intensive JJ cord-263267-oj7rmy8m 14 42 care care NN cord-263267-oj7rmy8m 14 43 unit unit NN cord-263267-oj7rmy8m 14 44 ( ( -LRB- cord-263267-oj7rmy8m 14 45 ICU ICU NNP cord-263267-oj7rmy8m 14 46 ) ) -RRB- cord-263267-oj7rmy8m 14 47 . . . cord-263267-oj7rmy8m 15 1 10 10 CD cord-263267-oj7rmy8m 15 2 How how WRB cord-263267-oj7rmy8m 15 3 can can MD cord-263267-oj7rmy8m 15 4 we -PRON- PRP cord-263267-oj7rmy8m 15 5 explain explain VB cord-263267-oj7rmy8m 15 6 these these DT cord-263267-oj7rmy8m 15 7 discrepancies discrepancy NNS cord-263267-oj7rmy8m 15 8 and and CC cord-263267-oj7rmy8m 15 9 how how WRB cord-263267-oj7rmy8m 15 10 should should MD cord-263267-oj7rmy8m 15 11 antimalarial antimalarial JJ cord-263267-oj7rmy8m 15 12 drugs drug NNS cord-263267-oj7rmy8m 15 13 be be VB cord-263267-oj7rmy8m 15 14 used use VBN cord-263267-oj7rmy8m 15 15 in in IN cord-263267-oj7rmy8m 15 16 the the DT cord-263267-oj7rmy8m 15 17 clinical clinical JJ cord-263267-oj7rmy8m 15 18 management management NN cord-263267-oj7rmy8m 15 19 of of IN cord-263267-oj7rmy8m 15 20 patients patient NNS cord-263267-oj7rmy8m 15 21 in in IN cord-263267-oj7rmy8m 15 22 the the DT cord-263267-oj7rmy8m 15 23 ICU ICU NNP cord-263267-oj7rmy8m 15 24 with with IN cord-263267-oj7rmy8m 15 25 severe severe JJ cord-263267-oj7rmy8m 15 26 COVID-19 covid-19 NN cord-263267-oj7rmy8m 15 27 ? ? . cord-263267-oj7rmy8m 16 1 First first RB cord-263267-oj7rmy8m 16 2 , , , cord-263267-oj7rmy8m 16 3 hydroxychloroquine hydroxychloroquine NNP cord-263267-oj7rmy8m 16 4 is be VBZ cord-263267-oj7rmy8m 16 5 not not RB cord-263267-oj7rmy8m 16 6 expensive expensive JJ cord-263267-oj7rmy8m 16 7 , , , cord-263267-oj7rmy8m 16 8 is be VBZ cord-263267-oj7rmy8m 16 9 readily readily RB cord-263267-oj7rmy8m 16 10 available available JJ cord-263267-oj7rmy8m 16 11 , , , cord-263267-oj7rmy8m 16 12 and and CC cord-263267-oj7rmy8m 16 13 seems seem VBZ cord-263267-oj7rmy8m 16 14 to to TO cord-263267-oj7rmy8m 16 15 be be VB cord-263267-oj7rmy8m 16 16 safe safe JJ cord-263267-oj7rmy8m 16 17 . . . cord-263267-oj7rmy8m 17 1 However however RB cord-263267-oj7rmy8m 17 2 , , , cord-263267-oj7rmy8m 17 3 clinical clinical JJ cord-263267-oj7rmy8m 17 4 observations observation NNS cord-263267-oj7rmy8m 17 5 of of IN cord-263267-oj7rmy8m 17 6 the the DT cord-263267-oj7rmy8m 17 7 effects effect NNS cord-263267-oj7rmy8m 17 8 of of IN cord-263267-oj7rmy8m 17 9 this this DT cord-263267-oj7rmy8m 17 10 drug drug NN cord-263267-oj7rmy8m 17 11 in in IN cord-263267-oj7rmy8m 17 12 patients patient NNS cord-263267-oj7rmy8m 17 13 with with IN cord-263267-oj7rmy8m 17 14 COVID-19 COVID-19 NNP cord-263267-oj7rmy8m 17 15 have have VBP cord-263267-oj7rmy8m 17 16 not not RB cord-263267-oj7rmy8m 17 17 included include VBN cord-263267-oj7rmy8m 17 18 critically critically RB cord-263267-oj7rmy8m 17 19 ill ill JJ cord-263267-oj7rmy8m 17 20 patients patient NNS cord-263267-oj7rmy8m 17 21 who who WP cord-263267-oj7rmy8m 17 22 are be VBP cord-263267-oj7rmy8m 17 23 receiving receive VBG cord-263267-oj7rmy8m 17 24 several several JJ cord-263267-oj7rmy8m 17 25 other other JJ cord-263267-oj7rmy8m 17 26 medications medication NNS cord-263267-oj7rmy8m 17 27 and and CC cord-263267-oj7rmy8m 17 28 have have VBP cord-263267-oj7rmy8m 17 29 organ organ NN cord-263267-oj7rmy8m 17 30 failure failure NN cord-263267-oj7rmy8m 17 31 , , , cord-263267-oj7rmy8m 17 32 such such JJ cord-263267-oj7rmy8m 17 33 as as IN cord-263267-oj7rmy8m 17 34 hepatic hepatic JJ cord-263267-oj7rmy8m 17 35 or or CC cord-263267-oj7rmy8m 17 36 renal renal JJ cord-263267-oj7rmy8m 17 37 dysfunction dysfunction NN cord-263267-oj7rmy8m 17 38 , , , cord-263267-oj7rmy8m 17 39 which which WDT cord-263267-oj7rmy8m 17 40 might may MD cord-263267-oj7rmy8m 17 41 influence influence VB cord-263267-oj7rmy8m 17 42 drug drug NN cord-263267-oj7rmy8m 17 43 metabolism metabolism NN cord-263267-oj7rmy8m 17 44 and and CC cord-263267-oj7rmy8m 17 45 potentially potentially RB cord-263267-oj7rmy8m 17 46 increase increase VB cord-263267-oj7rmy8m 17 47 the the DT cord-263267-oj7rmy8m 17 48 risk risk NN cord-263267-oj7rmy8m 17 49 of of IN cord-263267-oj7rmy8m 17 50 adverse adverse JJ cord-263267-oj7rmy8m 17 51 events event NNS cord-263267-oj7rmy8m 17 52 . . . cord-263267-oj7rmy8m 18 1 Second second JJ cord-263267-oj7rmy8m 18 2 , , , cord-263267-oj7rmy8m 18 3 clinical clinical JJ cord-263267-oj7rmy8m 18 4 data datum NNS cord-263267-oj7rmy8m 18 5 on on IN cord-263267-oj7rmy8m 18 6 hydroxychloroquine hydroxychloroquine NNP cord-263267-oj7rmy8m 18 7 are be VBP cord-263267-oj7rmy8m 18 8 far far RB cord-263267-oj7rmy8m 18 9 from from IN cord-263267-oj7rmy8m 18 10 convincing convince VBG cord-263267-oj7rmy8m 18 11 . . . cord-263267-oj7rmy8m 19 1 The the DT cord-263267-oj7rmy8m 19 2 first first JJ cord-263267-oj7rmy8m 19 3 study study NN cord-263267-oj7rmy8m 19 4 reported report VBN cord-263267-oj7rmy8m 19 5 by by IN cord-263267-oj7rmy8m 19 6 Philippe Philippe NNP cord-263267-oj7rmy8m 19 7 Gautret Gautret NNP cord-263267-oj7rmy8m 19 8 and and CC cord-263267-oj7rmy8m 19 9 colleagues colleague NNS cord-263267-oj7rmy8m 19 10 , , , cord-263267-oj7rmy8m 19 11 8 8 CD cord-263267-oj7rmy8m 19 12 which which WDT cord-263267-oj7rmy8m 19 13 indicated indicate VBD cord-263267-oj7rmy8m 19 14 that that IN cord-263267-oj7rmy8m 19 15 hydroxychloroquine hydroxychloroquine NN cord-263267-oj7rmy8m 19 16 might may MD cord-263267-oj7rmy8m 19 17 be be VB cord-263267-oj7rmy8m 19 18 effective effective JJ cord-263267-oj7rmy8m 19 19 , , , cord-263267-oj7rmy8m 19 20 had have VBD cord-263267-oj7rmy8m 19 21 several several JJ cord-263267-oj7rmy8m 19 22 limitations limitation NNS cord-263267-oj7rmy8m 19 23 : : : cord-263267-oj7rmy8m 19 24 a a DT cord-263267-oj7rmy8m 19 25 small small JJ cord-263267-oj7rmy8m 19 26 cohort cohort NN cord-263267-oj7rmy8m 19 27 of of IN cord-263267-oj7rmy8m 19 28 patients patient NNS cord-263267-oj7rmy8m 19 29 , , , cord-263267-oj7rmy8m 19 30 with with IN cord-263267-oj7rmy8m 19 31 only only RB cord-263267-oj7rmy8m 19 32 20 20 CD cord-263267-oj7rmy8m 19 33 participants participant NNS cord-263267-oj7rmy8m 19 34 who who WP cord-263267-oj7rmy8m 19 35 received receive VBD cord-263267-oj7rmy8m 19 36 hydroxychloroquine hydroxychloroquine NNP cord-263267-oj7rmy8m 19 37 ( ( -LRB- cord-263267-oj7rmy8m 19 38 six six CD cord-263267-oj7rmy8m 19 39 of of IN cord-263267-oj7rmy8m 19 40 whom whom WP cord-263267-oj7rmy8m 19 41 received receive VBD cord-263267-oj7rmy8m 19 42 azithromycin azithromycin NNP cord-263267-oj7rmy8m 19 43 ) ) -RRB- cord-263267-oj7rmy8m 19 44 and and CC cord-263267-oj7rmy8m 19 45 16 16 CD cord-263267-oj7rmy8m 19 46 controls control NNS cord-263267-oj7rmy8m 19 47 included include VBN cord-263267-oj7rmy8m 19 48 in in IN cord-263267-oj7rmy8m 19 49 the the DT cord-263267-oj7rmy8m 19 50 final final JJ cord-263267-oj7rmy8m 19 51 analysis analysis NN cord-263267-oj7rmy8m 19 52 ; ; : cord-263267-oj7rmy8m 19 53 a a DT cord-263267-oj7rmy8m 19 54 very very RB cord-263267-oj7rmy8m 19 55 short short JJ cord-263267-oj7rmy8m 19 56 observation observation NN cord-263267-oj7rmy8m 19 57 period period NN cord-263267-oj7rmy8m 19 58 ( ( -LRB- cord-263267-oj7rmy8m 19 59 6 6 CD cord-263267-oj7rmy8m 19 60 days day NNS cord-263267-oj7rmy8m 19 61 ) ) -RRB- cord-263267-oj7rmy8m 19 62 ; ; : cord-263267-oj7rmy8m 19 63 absence absence NN cord-263267-oj7rmy8m 19 64 of of IN cord-263267-oj7rmy8m 19 65 randomisation randomisation NN cord-263267-oj7rmy8m 19 66 , , , cord-263267-oj7rmy8m 19 67 raising raise VBG cord-263267-oj7rmy8m 19 68 concerns concern NNS cord-263267-oj7rmy8m 19 69 about about IN cord-263267-oj7rmy8m 19 70 selection selection NN cord-263267-oj7rmy8m 19 71 bias bias NN cord-263267-oj7rmy8m 19 72 and and CC cord-263267-oj7rmy8m 19 73 imbalance imbalance NN cord-263267-oj7rmy8m 19 74 of of IN cord-263267-oj7rmy8m 19 75 baseline baseline JJ cord-263267-oj7rmy8m 19 76 characteristics characteristic NNS cord-263267-oj7rmy8m 19 77 in in IN cord-263267-oj7rmy8m 19 78 the the DT cord-263267-oj7rmy8m 19 79 intervention intervention NN cord-263267-oj7rmy8m 19 80 and and CC cord-263267-oj7rmy8m 19 81 control control NN cord-263267-oj7rmy8m 19 82 groups group NNS cord-263267-oj7rmy8m 19 83 ; ; : cord-263267-oj7rmy8m 19 84 and and CC cord-263267-oj7rmy8m 19 85 no no DT cord-263267-oj7rmy8m 19 86 report report NN cord-263267-oj7rmy8m 19 87 of of IN cord-263267-oj7rmy8m 19 88 effects effect NNS cord-263267-oj7rmy8m 19 89 on on IN cord-263267-oj7rmy8m 19 90 clinical clinical JJ cord-263267-oj7rmy8m 19 91 evolution evolution NN cord-263267-oj7rmy8m 19 92 ( ( -LRB- cord-263267-oj7rmy8m 19 93 6 6 CD cord-263267-oj7rmy8m 19 94 [ [ -LRB- cord-263267-oj7rmy8m 19 95 17 17 CD cord-263267-oj7rmy8m 19 96 % % NN cord-263267-oj7rmy8m 19 97 ] ] -RRB- cord-263267-oj7rmy8m 19 98 patients patient NNS cord-263267-oj7rmy8m 19 99 were be VBD cord-263267-oj7rmy8m 19 100 asymptomatic asymptomatic JJ cord-263267-oj7rmy8m 19 101 and and CC cord-263267-oj7rmy8m 19 102 only only RB cord-263267-oj7rmy8m 19 103 8 8 CD cord-263267-oj7rmy8m 19 104 [ [ -LRB- cord-263267-oj7rmy8m 19 105 22 22 CD cord-263267-oj7rmy8m 19 106 % % NN cord-263267-oj7rmy8m 19 107 ] ] -RRB- cord-263267-oj7rmy8m 19 108 had have VBD cord-263267-oj7rmy8m 19 109 pneumonia pneumonia NN cord-263267-oj7rmy8m 19 110 ) ) -RRB- cord-263267-oj7rmy8m 19 111 . . . cord-263267-oj7rmy8m 20 1 The the DT cord-263267-oj7rmy8m 20 2 second second JJ cord-263267-oj7rmy8m 20 3 French french JJ cord-263267-oj7rmy8m 20 4 study study NN cord-263267-oj7rmy8m 20 5 , , , cord-263267-oj7rmy8m 20 6 although although IN cord-263267-oj7rmy8m 20 7 larger large JJR cord-263267-oj7rmy8m 20 8 , , , cord-263267-oj7rmy8m 20 9 had have VBD cord-263267-oj7rmy8m 20 10 no no DT cord-263267-oj7rmy8m 20 11 control control NN cord-263267-oj7rmy8m 20 12 arm arm NN cord-263267-oj7rmy8m 20 13 . . . cord-263267-oj7rmy8m 21 1 9 9 CD cord-263267-oj7rmy8m 22 1 Moreover moreover RB cord-263267-oj7rmy8m 22 2 , , , cord-263267-oj7rmy8m 22 3 the the DT cord-263267-oj7rmy8m 22 4 inclusion inclusion NN cord-263267-oj7rmy8m 22 5 and and CC cord-263267-oj7rmy8m 22 6 exclusion exclusion NN cord-263267-oj7rmy8m 22 7 criteria criterion NNS cord-263267-oj7rmy8m 22 8 were be VBD cord-263267-oj7rmy8m 22 9 poorly poorly RB cord-263267-oj7rmy8m 22 10 described describe VBN cord-263267-oj7rmy8m 22 11 , , , cord-263267-oj7rmy8m 22 12 most most JJS cord-263267-oj7rmy8m 22 13 patients patient NNS cord-263267-oj7rmy8m 22 14 ( ( -LRB- cord-263267-oj7rmy8m 22 15 69 69 CD cord-263267-oj7rmy8m 22 16 of of IN cord-263267-oj7rmy8m 22 17 75 75 CD cord-263267-oj7rmy8m 22 18 [ [ -LRB- cord-263267-oj7rmy8m 22 19 92 92 CD cord-263267-oj7rmy8m 22 20 % % NN cord-263267-oj7rmy8m 22 21 ] ] -RRB- cord-263267-oj7rmy8m 22 22 ) ) -RRB- cord-263267-oj7rmy8m 22 23 had have VBD cord-263267-oj7rmy8m 22 24 a a DT cord-263267-oj7rmy8m 22 25 low low JJ cord-263267-oj7rmy8m 22 26 National National NNP cord-263267-oj7rmy8m 22 27 Early Early NNP cord-263267-oj7rmy8m 22 28 Warning Warning NNP cord-263267-oj7rmy8m 22 29 Score Score NNP cord-263267-oj7rmy8m 22 30 , , , cord-263267-oj7rmy8m 22 31 and and CC cord-263267-oj7rmy8m 22 32 the the DT cord-263267-oj7rmy8m 22 33 overall overall JJ cord-263267-oj7rmy8m 22 34 clinical clinical JJ cord-263267-oj7rmy8m 22 35 outcome outcome NN cord-263267-oj7rmy8m 22 36 was be VBD cord-263267-oj7rmy8m 22 37 similar similar JJ cord-263267-oj7rmy8m 22 38 to to IN cord-263267-oj7rmy8m 23 1 that that DT cord-263267-oj7rmy8m 23 2 reported report VBD cord-263267-oj7rmy8m 23 3 for for IN cord-263267-oj7rmy8m 23 4 untreated untreated JJ cord-263267-oj7rmy8m 23 5 patients patient NNS cord-263267-oj7rmy8m 23 6 with with IN cord-263267-oj7rmy8m 23 7 COVID-19 COVID-19 NNP cord-263267-oj7rmy8m 23 8 . . . cord-263267-oj7rmy8m 23 9 11 11 CD cord-263267-oj7rmy8m 24 1 The the DT cord-263267-oj7rmy8m 24 2 combination combination NN cord-263267-oj7rmy8m 24 3 of of IN cord-263267-oj7rmy8m 24 4 hydroxychloroquine hydroxychloroquine NN cord-263267-oj7rmy8m 24 5 and and CC cord-263267-oj7rmy8m 24 6 azithromycin azithromycin NNP cord-263267-oj7rmy8m 24 7 was be VBD cord-263267-oj7rmy8m 24 8 associated associate VBN cord-263267-oj7rmy8m 24 9 with with IN cord-263267-oj7rmy8m 24 10 reduced reduce VBN cord-263267-oj7rmy8m 24 11 viral viral JJ cord-263267-oj7rmy8m 24 12 load load NN cord-263267-oj7rmy8m 24 13 ( ( -LRB- cord-263267-oj7rmy8m 24 14 83 83 CD cord-263267-oj7rmy8m 24 15 % % NN cord-263267-oj7rmy8m 24 16 and and CC cord-263267-oj7rmy8m 24 17 93 93 CD cord-263267-oj7rmy8m 24 18 % % NN cord-263267-oj7rmy8m 24 19 tested test VBD cord-263267-oj7rmy8m 24 20 negative negative JJ cord-263267-oj7rmy8m 24 21 on on IN cord-263267-oj7rmy8m 24 22 days day NNS cord-263267-oj7rmy8m 24 23 7 7 CD cord-263267-oj7rmy8m 24 24 and and CC cord-263267-oj7rmy8m 24 25 8 8 CD cord-263267-oj7rmy8m 24 26 , , , cord-263267-oj7rmy8m 24 27 respectively respectively RB cord-263267-oj7rmy8m 24 28 ) ) -RRB- cord-263267-oj7rmy8m 24 29 , , , cord-263267-oj7rmy8m 24 30 but but CC cord-263267-oj7rmy8m 24 31 no no DT cord-263267-oj7rmy8m 24 32 other other JJ cord-263267-oj7rmy8m 24 33 clinically clinically RB cord-263267-oj7rmy8m 24 34 relevant relevant JJ cord-263267-oj7rmy8m 24 35 outcomes outcome NNS cord-263267-oj7rmy8m 24 36 were be VBD cord-263267-oj7rmy8m 24 37 reported report VBN cord-263267-oj7rmy8m 24 38 . . . cord-263267-oj7rmy8m 25 1 In in IN cord-263267-oj7rmy8m 25 2 a a DT cord-263267-oj7rmy8m 25 3 trial trial NN cord-263267-oj7rmy8m 25 4 in in IN cord-263267-oj7rmy8m 25 5 30 30 CD cord-263267-oj7rmy8m 25 6 patients patient NNS cord-263267-oj7rmy8m 25 7 with with IN cord-263267-oj7rmy8m 25 8 COVID-19 COVID-19 NNP cord-263267-oj7rmy8m 25 9 , , , cord-263267-oj7rmy8m 25 10 Jun Jun NNP cord-263267-oj7rmy8m 25 11 Chen Chen NNP cord-263267-oj7rmy8m 25 12 and and CC cord-263267-oj7rmy8m 25 13 colleagues colleague NNS cord-263267-oj7rmy8m 25 14 found find VBD cord-263267-oj7rmy8m 25 15 no no DT cord-263267-oj7rmy8m 25 16 significant significant JJ cord-263267-oj7rmy8m 25 17 difference difference NN cord-263267-oj7rmy8m 25 18 in in IN cord-263267-oj7rmy8m 25 19 nasopharyngeal nasopharyngeal JJ cord-263267-oj7rmy8m 25 20 viral viral JJ cord-263267-oj7rmy8m 25 21 carriage carriage NN cord-263267-oj7rmy8m 25 22 on on IN cord-263267-oj7rmy8m 25 23 day day NN cord-263267-oj7rmy8m 25 24 7 7 CD cord-263267-oj7rmy8m 25 25 when when WRB cord-263267-oj7rmy8m 25 26 hydroxychloroquine hydroxychloroquine NNP cord-263267-oj7rmy8m 25 27 was be VBD cord-263267-oj7rmy8m 25 28 compared compare VBN cord-263267-oj7rmy8m 25 29 with with IN cord-263267-oj7rmy8m 25 30 local local JJ cord-263267-oj7rmy8m 25 31 standard standard NN cord-263267-oj7rmy8m 25 32 of of IN cord-263267-oj7rmy8m 25 33 care care NN cord-263267-oj7rmy8m 25 34 ; ; : cord-263267-oj7rmy8m 25 35 however however RB cord-263267-oj7rmy8m 25 36 , , , cord-263267-oj7rmy8m 25 37 concomitant concomitant JJ cord-263267-oj7rmy8m 25 38 antivirals antiviral NNS cord-263267-oj7rmy8m 25 39 were be VBD cord-263267-oj7rmy8m 25 40 given give VBN cord-263267-oj7rmy8m 25 41 , , , cord-263267-oj7rmy8m 25 42 which which WDT cord-263267-oj7rmy8m 25 43 might may MD cord-263267-oj7rmy8m 25 44 have have VB cord-263267-oj7rmy8m 25 45 served serve VBN cord-263267-oj7rmy8m 25 46 as as IN cord-263267-oj7rmy8m 25 47 confounders confounder NNS cord-263267-oj7rmy8m 25 48 when when WRB cord-263267-oj7rmy8m 25 49 interpreting interpret VBG cord-263267-oj7rmy8m 25 50 the the DT cord-263267-oj7rmy8m 25 51 results result NNS cord-263267-oj7rmy8m 25 52 of of IN cord-263267-oj7rmy8m 25 53 this this DT cord-263267-oj7rmy8m 25 54 study study NN cord-263267-oj7rmy8m 25 55 . . . cord-263267-oj7rmy8m 26 1 12 12 CD cord-263267-oj7rmy8m 27 1 In in IN cord-263267-oj7rmy8m 27 2 a a DT cord-263267-oj7rmy8m 27 3 second second JJ cord-263267-oj7rmy8m 27 4 Chinese chinese JJ cord-263267-oj7rmy8m 27 5 trial trial NN cord-263267-oj7rmy8m 27 6 in in IN cord-263267-oj7rmy8m 27 7 62 62 CD cord-263267-oj7rmy8m 27 8 patients patient NNS cord-263267-oj7rmy8m 27 9 , , , cord-263267-oj7rmy8m 27 10 Zhaowei Zhaowei NNP cord-263267-oj7rmy8m 27 11 Chen Chen NNP cord-263267-oj7rmy8m 27 12 and and CC cord-263267-oj7rmy8m 27 13 colleagues colleague NNS cord-263267-oj7rmy8m 27 14 showed show VBD cord-263267-oj7rmy8m 27 15 that that IN cord-263267-oj7rmy8m 27 16 hydroxychloroquine hydroxychloroquine NN cord-263267-oj7rmy8m 27 17 treatment treatment NN cord-263267-oj7rmy8m 27 18 was be VBD cord-263267-oj7rmy8m 27 19 associated associate VBN cord-263267-oj7rmy8m 27 20 with with IN cord-263267-oj7rmy8m 27 21 a a DT cord-263267-oj7rmy8m 27 22 shorter short JJR cord-263267-oj7rmy8m 27 23 time time NN cord-263267-oj7rmy8m 27 24 to to IN cord-263267-oj7rmy8m 27 25 clinical clinical JJ cord-263267-oj7rmy8m 27 26 recovery recovery NN cord-263267-oj7rmy8m 27 27 ( ( -LRB- cord-263267-oj7rmy8m 27 28 temperature temperature NN cord-263267-oj7rmy8m 27 29 and and CC cord-263267-oj7rmy8m 27 30 cough cough NN cord-263267-oj7rmy8m 27 31 ) ) -RRB- cord-263267-oj7rmy8m 27 32 than than IN cord-263267-oj7rmy8m 27 33 placebo placebo NN cord-263267-oj7rmy8m 27 34 ; ; : cord-263267-oj7rmy8m 27 35 13 13 CD cord-263267-oj7rmy8m 27 36 the the DT cord-263267-oj7rmy8m 27 37 participants participant NNS cord-263267-oj7rmy8m 27 38 had have VBD cord-263267-oj7rmy8m 27 39 mild mild JJ cord-263267-oj7rmy8m 27 40 disease disease NN cord-263267-oj7rmy8m 27 41 ( ( -LRB- cord-263267-oj7rmy8m 27 42 SaO SaO NNP cord-263267-oj7rmy8m 28 1 2 2 LS cord-263267-oj7rmy8m 28 2 /SpO /SpO . cord-263267-oj7rmy8m 29 1 2 2 LS cord-263267-oj7rmy8m 29 2 > > SYM cord-263267-oj7rmy8m 29 3 93 93 CD cord-263267-oj7rmy8m 29 4 % % NN cord-263267-oj7rmy8m 29 5 or or CC cord-263267-oj7rmy8m 29 6 PaO pao NN cord-263267-oj7rmy8m 29 7 2 2 CD cord-263267-oj7rmy8m 30 1 /FiO /FiO NFP cord-263267-oj7rmy8m 30 2 2 2 CD cord-263267-oj7rmy8m 30 3 > > XX cord-263267-oj7rmy8m 30 4 300 300 CD cord-263267-oj7rmy8m 30 5 ) ) -RRB- cord-263267-oj7rmy8m 31 1 and and CC cord-263267-oj7rmy8m 31 2 it -PRON- PRP cord-263267-oj7rmy8m 31 3 is be VBZ cord-263267-oj7rmy8m 31 4 not not RB cord-263267-oj7rmy8m 31 5 possible possible JJ cord-263267-oj7rmy8m 31 6 to to TO cord-263267-oj7rmy8m 31 7 extrapolate extrapolate VB cord-263267-oj7rmy8m 31 8 these these DT cord-263267-oj7rmy8m 31 9 results result NNS cord-263267-oj7rmy8m 31 10 to to TO cord-263267-oj7rmy8m 31 11 critically critically RB cord-263267-oj7rmy8m 31 12 ill ill VB cord-263267-oj7rmy8m 31 13 patients patient NNS cord-263267-oj7rmy8m 31 14 . . . cord-263267-oj7rmy8m 32 1 A a DT cord-263267-oj7rmy8m 32 2 study study NN cord-263267-oj7rmy8m 32 3 of of IN cord-263267-oj7rmy8m 32 4 11 11 CD cord-263267-oj7rmy8m 32 5 patients patient NNS cord-263267-oj7rmy8m 32 6 with with IN cord-263267-oj7rmy8m 32 7 COVID-19 covid-19 JJ cord-263267-oj7rmy8m 32 8 reported reported JJ cord-263267-oj7rmy8m 32 9 persistence persistence NN cord-263267-oj7rmy8m 32 10 of of IN cord-263267-oj7rmy8m 32 11 SARS SARS NNP cord-263267-oj7rmy8m 32 12 - - HYPH cord-263267-oj7rmy8m 32 13 CoV-2 CoV-2 NNP cord-263267-oj7rmy8m 32 14 in in IN cord-263267-oj7rmy8m 32 15 the the DT cord-263267-oj7rmy8m 32 16 nasopharyngeal nasopharyngeal JJ cord-263267-oj7rmy8m 32 17 swab swab NN cord-263267-oj7rmy8m 32 18 in in IN cord-263267-oj7rmy8m 32 19 8 8 CD cord-263267-oj7rmy8m 32 20 of of IN cord-263267-oj7rmy8m 32 21 10 10 CD cord-263267-oj7rmy8m 32 22 patients patient NNS cord-263267-oj7rmy8m 32 23 receiving receive VBG cord-263267-oj7rmy8m 32 24 hydroxychloroquine hydroxychloroquine NN cord-263267-oj7rmy8m 32 25 . . . cord-263267-oj7rmy8m 33 1 14 14 CD cord-263267-oj7rmy8m 33 2 Third Third NNP cord-263267-oj7rmy8m 33 3 , , , cord-263267-oj7rmy8m 33 4 whether whether IN cord-263267-oj7rmy8m 33 5 viral viral JJ cord-263267-oj7rmy8m 33 6 load load NN cord-263267-oj7rmy8m 33 7 is be VBZ cord-263267-oj7rmy8m 33 8 important important JJ cord-263267-oj7rmy8m 33 9 in in IN cord-263267-oj7rmy8m 33 10 critically critically RB cord-263267-oj7rmy8m 33 11 ill ill JJ cord-263267-oj7rmy8m 33 12 COVID-19 covid-19 CD cord-263267-oj7rmy8m 33 13 patients patient NNS cord-263267-oj7rmy8m 33 14 or or CC cord-263267-oj7rmy8m 33 15 whether whether IN cord-263267-oj7rmy8m 33 16 progressive progressive JJ cord-263267-oj7rmy8m 33 17 lung lung NN cord-263267-oj7rmy8m 33 18 involvement involvement NN cord-263267-oj7rmy8m 33 19 is be VBZ cord-263267-oj7rmy8m 33 20 related relate VBN cord-263267-oj7rmy8m 33 21 to to IN cord-263267-oj7rmy8m 33 22 an an DT cord-263267-oj7rmy8m 33 23 overwhelming overwhelming JJ cord-263267-oj7rmy8m 33 24 inflammatory inflammatory JJ cord-263267-oj7rmy8m 33 25 response response NN cord-263267-oj7rmy8m 33 26 , , , cord-263267-oj7rmy8m 33 27 unrelated unrelated JJ cord-263267-oj7rmy8m 33 28 to to IN cord-263267-oj7rmy8m 33 29 the the DT cord-263267-oj7rmy8m 33 30 virus virus NN cord-263267-oj7rmy8m 33 31 , , , cord-263267-oj7rmy8m 33 32 remains remain VBZ cord-263267-oj7rmy8m 33 33 to to TO cord-263267-oj7rmy8m 33 34 be be VB cord-263267-oj7rmy8m 33 35 clarified clarify VBN cord-263267-oj7rmy8m 33 36 . . . cord-263267-oj7rmy8m 34 1 An an DT cord-263267-oj7rmy8m 34 2 observational observational JJ cord-263267-oj7rmy8m 34 3 study study NN cord-263267-oj7rmy8m 34 4 found find VBD cord-263267-oj7rmy8m 34 5 that that IN cord-263267-oj7rmy8m 34 6 high high JJ cord-263267-oj7rmy8m 34 7 viral viral JJ cord-263267-oj7rmy8m 34 8 load load NN cord-263267-oj7rmy8m 34 9 was be VBD cord-263267-oj7rmy8m 34 10 associated associate VBN cord-263267-oj7rmy8m 34 11 with with IN cord-263267-oj7rmy8m 34 12 disease disease NN cord-263267-oj7rmy8m 34 13 severity severity NN cord-263267-oj7rmy8m 34 14 ; ; : cord-263267-oj7rmy8m 34 15 13 13 CD cord-263267-oj7rmy8m 34 16 however however RB cord-263267-oj7rmy8m 34 17 , , , cord-263267-oj7rmy8m 34 18 the the DT cord-263267-oj7rmy8m 34 19 influence influence NN cord-263267-oj7rmy8m 34 20 of of IN cord-263267-oj7rmy8m 34 21 antiviral antiviral JJ cord-263267-oj7rmy8m 34 22 strategies strategy NNS cord-263267-oj7rmy8m 34 23 in in IN cord-263267-oj7rmy8m 34 24 such such JJ cord-263267-oj7rmy8m 34 25 advanced advanced JJ cord-263267-oj7rmy8m 34 26 forms form NNS cord-263267-oj7rmy8m 34 27 of of IN cord-263267-oj7rmy8m 34 28 the the DT cord-263267-oj7rmy8m 34 29 disease disease NN cord-263267-oj7rmy8m 34 30 remains remain VBZ cord-263267-oj7rmy8m 34 31 unproven unproven JJ cord-263267-oj7rmy8m 34 32 . . . cord-263267-oj7rmy8m 35 1 Fourth fourth RB cord-263267-oj7rmy8m 35 2 , , , cord-263267-oj7rmy8m 35 3 the the DT cord-263267-oj7rmy8m 35 4 search search NN cord-263267-oj7rmy8m 35 5 for for IN cord-263267-oj7rmy8m 35 6 effective effective JJ cord-263267-oj7rmy8m 35 7 new new JJ cord-263267-oj7rmy8m 35 8 drugs drug NNS cord-263267-oj7rmy8m 35 9 requires require VBZ cord-263267-oj7rmy8m 35 10 appropriate appropriate JJ cord-263267-oj7rmy8m 35 11 and and CC cord-263267-oj7rmy8m 35 12 valid valid JJ cord-263267-oj7rmy8m 35 13 trials trial NNS cord-263267-oj7rmy8m 35 14 - - HYPH cord-263267-oj7rmy8m 35 15 ie ie JJ cord-263267-oj7rmy8m 35 16 , , , cord-263267-oj7rmy8m 35 17 prospective prospective JJ cord-263267-oj7rmy8m 35 18 , , , cord-263267-oj7rmy8m 35 19 randomised randomised JJ cord-263267-oj7rmy8m 35 20 , , , cord-263267-oj7rmy8m 35 21 placebo placebo NN cord-263267-oj7rmy8m 35 22 - - HYPH cord-263267-oj7rmy8m 35 23 controlled control VBN cord-263267-oj7rmy8m 35 24 clinical clinical JJ cord-263267-oj7rmy8m 35 25 studies study NNS cord-263267-oj7rmy8m 35 26 . . . cord-263267-oj7rmy8m 36 1 Although although IN cord-263267-oj7rmy8m 36 2 many many JJ cord-263267-oj7rmy8m 36 3 drugs drug NNS cord-263267-oj7rmy8m 36 4 have have VBP cord-263267-oj7rmy8m 36 5 in in IN cord-263267-oj7rmy8m 36 6 - - HYPH cord-263267-oj7rmy8m 36 7 vitro vitro FW cord-263267-oj7rmy8m 36 8 activity activity NN cord-263267-oj7rmy8m 36 9 against against IN cord-263267-oj7rmy8m 36 10 the the DT cord-263267-oj7rmy8m 36 11 virus virus NN cord-263267-oj7rmy8m 36 12 , , , cord-263267-oj7rmy8m 36 13 the the DT cord-263267-oj7rmy8m 36 14 proposal proposal NN cord-263267-oj7rmy8m 36 15 that that IN cord-263267-oj7rmy8m 36 16 such such JJ cord-263267-oj7rmy8m 36 17 drugs drug NNS cord-263267-oj7rmy8m 36 18 might may MD cord-263267-oj7rmy8m 36 19 provide provide VB cord-263267-oj7rmy8m 36 20 more more JJR cord-263267-oj7rmy8m 36 21 benefit benefit NN cord-263267-oj7rmy8m 36 22 than than IN cord-263267-oj7rmy8m 36 23 harm harm NN cord-263267-oj7rmy8m 36 24 is be VBZ cord-263267-oj7rmy8m 36 25 inappropriate inappropriate JJ cord-263267-oj7rmy8m 36 26 in in IN cord-263267-oj7rmy8m 36 27 the the DT cord-263267-oj7rmy8m 36 28 face face NN cord-263267-oj7rmy8m 36 29 of of IN cord-263267-oj7rmy8m 36 30 no no DT cord-263267-oj7rmy8m 36 31 clinical clinical JJ cord-263267-oj7rmy8m 36 32 evidence evidence NN cord-263267-oj7rmy8m 36 33 supporting support VBG cord-263267-oj7rmy8m 36 34 efficacy efficacy NN cord-263267-oj7rmy8m 36 35 and and CC cord-263267-oj7rmy8m 36 36 safety safety NN cord-263267-oj7rmy8m 36 37 in in IN cord-263267-oj7rmy8m 36 38 patients patient NNS cord-263267-oj7rmy8m 36 39 with with IN cord-263267-oj7rmy8m 36 40 COVID-19 COVID-19 NNP cord-263267-oj7rmy8m 36 41 . . . cord-263267-oj7rmy8m 37 1 International International NNP cord-263267-oj7rmy8m 37 2 multicentre multicentre NNP cord-263267-oj7rmy8m 37 3 studies study NNS cord-263267-oj7rmy8m 37 4 , , , cord-263267-oj7rmy8m 37 5 such such JJ cord-263267-oj7rmy8m 37 6 as as IN cord-263267-oj7rmy8m 37 7 the the DT cord-263267-oj7rmy8m 37 8 Discovery Discovery NNP cord-263267-oj7rmy8m 37 9 study study NN cord-263267-oj7rmy8m 37 10 ( ( -LRB- cord-263267-oj7rmy8m 37 11 NCT04315948 NCT04315948 NNP cord-263267-oj7rmy8m 37 12 ) ) -RRB- cord-263267-oj7rmy8m 37 13 and and CC cord-263267-oj7rmy8m 37 14 the the DT cord-263267-oj7rmy8m 37 15 Solidarity Solidarity NNP cord-263267-oj7rmy8m 37 16 study study NN cord-263267-oj7rmy8m 37 17 ( ( -LRB- cord-263267-oj7rmy8m 37 18 EudraCT EudraCT NNP cord-263267-oj7rmy8m 37 19 Number Number NNP cord-263267-oj7rmy8m 37 20 2020 2020 CD cord-263267-oj7rmy8m 37 21 - - HYPH cord-263267-oj7rmy8m 37 22 000982 000982 CD cord-263267-oj7rmy8m 37 23 - - SYM cord-263267-oj7rmy8m 37 24 18 18 CD cord-263267-oj7rmy8m 37 25 ) ) -RRB- cord-263267-oj7rmy8m 37 26 , , , cord-263267-oj7rmy8m 37 27 will will MD cord-263267-oj7rmy8m 37 28 randomise randomise VB cord-263267-oj7rmy8m 37 29 patients patient NNS cord-263267-oj7rmy8m 37 30 with with IN cord-263267-oj7rmy8m 37 31 COVID-19 COVID-19 NNP cord-263267-oj7rmy8m 37 32 to to TO cord-263267-oj7rmy8m 37 33 receive receive VB cord-263267-oj7rmy8m 37 34 different different JJ cord-263267-oj7rmy8m 37 35 antiviral antiviral JJ cord-263267-oj7rmy8m 37 36 drugs drug NNS cord-263267-oj7rmy8m 37 37 , , , cord-263267-oj7rmy8m 37 38 including include VBG cord-263267-oj7rmy8m 37 39 hydroxychloroquine hydroxychloroquine NN cord-263267-oj7rmy8m 37 40 , , , cord-263267-oj7rmy8m 37 41 in in IN cord-263267-oj7rmy8m 37 42 an an DT cord-263267-oj7rmy8m 37 43 adaptive adaptive JJ cord-263267-oj7rmy8m 37 44 study study NN cord-263267-oj7rmy8m 37 45 design design NN cord-263267-oj7rmy8m 37 46 . . . cord-263267-oj7rmy8m 38 1 These these DT cord-263267-oj7rmy8m 38 2 initiatives initiative NNS cord-263267-oj7rmy8m 38 3 will will MD cord-263267-oj7rmy8m 38 4 provide provide VB cord-263267-oj7rmy8m 38 5 important important JJ cord-263267-oj7rmy8m 38 6 data datum NNS cord-263267-oj7rmy8m 38 7 to to TO cord-263267-oj7rmy8m 38 8 guide guide VB cord-263267-oj7rmy8m 38 9 the the DT cord-263267-oj7rmy8m 38 10 management management NN cord-263267-oj7rmy8m 38 11 of of IN cord-263267-oj7rmy8m 38 12 patients patient NNS cord-263267-oj7rmy8m 38 13 with with IN cord-263267-oj7rmy8m 38 14 COVID-19 covid-19 VB cord-263267-oj7rmy8m 38 15 and and CC cord-263267-oj7rmy8m 38 16 help help VB cord-263267-oj7rmy8m 38 17 to to TO cord-263267-oj7rmy8m 38 18 improve improve VB cord-263267-oj7rmy8m 38 19 understanding understanding NN cord-263267-oj7rmy8m 38 20 of of IN cord-263267-oj7rmy8m 38 21 the the DT cord-263267-oj7rmy8m 38 22 effects effect NNS cord-263267-oj7rmy8m 38 23 of of IN cord-263267-oj7rmy8m 38 24 antiviral antiviral JJ cord-263267-oj7rmy8m 38 25 therapies therapy NNS cord-263267-oj7rmy8m 38 26 in in IN cord-263267-oj7rmy8m 38 27 critically critically RB cord-263267-oj7rmy8m 38 28 ill ill JJ cord-263267-oj7rmy8m 38 29 patients patient NNS cord-263267-oj7rmy8m 38 30 . . . cord-263267-oj7rmy8m 39 1 Whether whether IN cord-263267-oj7rmy8m 39 2 antimalarial antimalarial JJ cord-263267-oj7rmy8m 39 3 drugs drug NNS cord-263267-oj7rmy8m 39 4 could could MD cord-263267-oj7rmy8m 39 5 be be VB cord-263267-oj7rmy8m 39 6 effective effective JJ cord-263267-oj7rmy8m 39 7 in in IN cord-263267-oj7rmy8m 39 8 changing change VBG cord-263267-oj7rmy8m 39 9 the the DT cord-263267-oj7rmy8m 39 10 disease disease NN cord-263267-oj7rmy8m 39 11 course course NN cord-263267-oj7rmy8m 39 12 in in IN cord-263267-oj7rmy8m 39 13 patients patient NNS cord-263267-oj7rmy8m 39 14 with with IN cord-263267-oj7rmy8m 39 15 severe severe JJ cord-263267-oj7rmy8m 39 16 COVID-19-in COVID-19-in NNP cord-263267-oj7rmy8m 39 17 particular particular JJ cord-263267-oj7rmy8m 39 18 , , , cord-263267-oj7rmy8m 39 19 in in IN cord-263267-oj7rmy8m 39 20 cases case NNS cord-263267-oj7rmy8m 39 21 requiring require VBG cord-263267-oj7rmy8m 39 22 ICU ICU NNP cord-263267-oj7rmy8m 39 23 admission admission NN cord-263267-oj7rmy8m 39 24 - - HYPH cord-263267-oj7rmy8m 39 25 remains remain VBZ cord-263267-oj7rmy8m 39 26 unknown unknown JJ cord-263267-oj7rmy8m 39 27 . . . cord-263267-oj7rmy8m 40 1 Moreover moreover RB cord-263267-oj7rmy8m 40 2 , , , cord-263267-oj7rmy8m 40 3 for for IN cord-263267-oj7rmy8m 40 4 patients patient NNS cord-263267-oj7rmy8m 40 5 receiving receive VBG cord-263267-oj7rmy8m 40 6 antimalarial antimalarial JJ cord-263267-oj7rmy8m 40 7 drugs drug NNS cord-263267-oj7rmy8m 40 8 who who WP cord-263267-oj7rmy8m 40 9 then then RB cord-263267-oj7rmy8m 40 10 require require VBP cord-263267-oj7rmy8m 40 11 ICU ICU NNP cord-263267-oj7rmy8m 40 12 admission admission NN cord-263267-oj7rmy8m 40 13 , , , cord-263267-oj7rmy8m 40 14 it -PRON- PRP cord-263267-oj7rmy8m 40 15 is be VBZ cord-263267-oj7rmy8m 40 16 not not RB cord-263267-oj7rmy8m 40 17 known know VBN cord-263267-oj7rmy8m 40 18 whether whether IN cord-263267-oj7rmy8m 40 19 the the DT cord-263267-oj7rmy8m 40 20 drug drug NN cord-263267-oj7rmy8m 40 21 should should MD cord-263267-oj7rmy8m 40 22 be be VB cord-263267-oj7rmy8m 40 23 continued continue VBN cord-263267-oj7rmy8m 40 24 or or CC cord-263267-oj7rmy8m 40 25 considered consider VBN cord-263267-oj7rmy8m 40 26 clinically clinically RB cord-263267-oj7rmy8m 40 27 ineffective ineffective JJ cord-263267-oj7rmy8m 40 28 and and CC cord-263267-oj7rmy8m 40 29 stopped stop VBD cord-263267-oj7rmy8m 40 30 . . . cord-263267-oj7rmy8m 41 1 Assessing assess VBG cord-263267-oj7rmy8m 41 2 viral viral JJ cord-263267-oj7rmy8m 41 3 load load NN cord-263267-oj7rmy8m 41 4 , , , cord-263267-oj7rmy8m 41 5 either either CC cord-263267-oj7rmy8m 41 6 on on IN cord-263267-oj7rmy8m 41 7 a a DT cord-263267-oj7rmy8m 41 8 nasopharyngeal nasopharyngeal JJ cord-263267-oj7rmy8m 41 9 swab swab NN cord-263267-oj7rmy8m 41 10 or or CC cord-263267-oj7rmy8m 41 11 in in IN cord-263267-oj7rmy8m 41 12 bronchoalveolar bronchoalveolar NNP cord-263267-oj7rmy8m 41 13 lavage lavage NN cord-263267-oj7rmy8m 41 14 fluid fluid NN cord-263267-oj7rmy8m 41 15 , , , cord-263267-oj7rmy8m 41 16 might may MD cord-263267-oj7rmy8m 41 17 be be VB cord-263267-oj7rmy8m 41 18 of of IN cord-263267-oj7rmy8m 41 19 use use NN cord-263267-oj7rmy8m 41 20 in in IN cord-263267-oj7rmy8m 41 21 understanding understanding NN cord-263267-oj7rmy8m 41 22 whether whether IN cord-263267-oj7rmy8m 41 23 targeting target VBG cord-263267-oj7rmy8m 41 24 viral viral JJ cord-263267-oj7rmy8m 41 25 replication replication NN cord-263267-oj7rmy8m 41 26 , , , cord-263267-oj7rmy8m 41 27 rather rather RB cord-263267-oj7rmy8m 41 28 than than IN cord-263267-oj7rmy8m 41 29 other other JJ cord-263267-oj7rmy8m 41 30 injurious injurious JJ cord-263267-oj7rmy8m 41 31 lung lung NN cord-263267-oj7rmy8m 41 32 pathways pathway NNS cord-263267-oj7rmy8m 41 33 , , , cord-263267-oj7rmy8m 41 34 is be VBZ cord-263267-oj7rmy8m 41 35 a a DT cord-263267-oj7rmy8m 41 36 reasonable reasonable JJ cord-263267-oj7rmy8m 41 37 therapeutic therapeutic JJ cord-263267-oj7rmy8m 41 38 strategy strategy NN cord-263267-oj7rmy8m 41 39 . . . cord-263267-oj7rmy8m 42 1 Future future JJ cord-263267-oj7rmy8m 42 2 studies study NNS cord-263267-oj7rmy8m 42 3 should should MD cord-263267-oj7rmy8m 42 4 aim aim VB cord-263267-oj7rmy8m 42 5 to to TO cord-263267-oj7rmy8m 42 6 clarify clarify VB cord-263267-oj7rmy8m 42 7 the the DT cord-263267-oj7rmy8m 42 8 precise precise JJ cord-263267-oj7rmy8m 42 9 role role NN cord-263267-oj7rmy8m 42 10 , , , cord-263267-oj7rmy8m 42 11 if if IN cord-263267-oj7rmy8m 42 12 any any DT cord-263267-oj7rmy8m 42 13 , , , cord-263267-oj7rmy8m 42 14 of of IN cord-263267-oj7rmy8m 42 15 chloroquine chloroquine NN cord-263267-oj7rmy8m 42 16 and and CC cord-263267-oj7rmy8m 42 17 hydroxychloroquine hydroxychloroquine NN cord-263267-oj7rmy8m 42 18 in in IN cord-263267-oj7rmy8m 42 19 critically critically RB cord-263267-oj7rmy8m 42 20 ill ill JJ cord-263267-oj7rmy8m 42 21 patients patient NNS cord-263267-oj7rmy8m 42 22 with with IN cord-263267-oj7rmy8m 42 23 COVID-19 COVID-19 NNP cord-263267-oj7rmy8m 42 24 . . . cord-263267-oj7rmy8m 43 1 We -PRON- PRP cord-263267-oj7rmy8m 43 2 declare declare VBP cord-263267-oj7rmy8m 43 3 no no DT cord-263267-oj7rmy8m 43 4 competing compete VBG cord-263267-oj7rmy8m 43 5 interests interest NNS cord-263267-oj7rmy8m 43 6 . . . cord-263267-oj7rmy8m 43 7 _SP cord-263267-oj7rmy8m 44 1 A a DT cord-263267-oj7rmy8m 44 2 systematic systematic JJ cord-263267-oj7rmy8m 44 3 review review NN cord-263267-oj7rmy8m 44 4 on on IN cord-263267-oj7rmy8m 44 5 the the DT cord-263267-oj7rmy8m 44 6 efficacy efficacy NN cord-263267-oj7rmy8m 44 7 and and CC cord-263267-oj7rmy8m 44 8 safety safety NN cord-263267-oj7rmy8m 44 9 of of IN cord-263267-oj7rmy8m 44 10 chloroquine chloroquine NN cord-263267-oj7rmy8m 44 11 for for IN cord-263267-oj7rmy8m 44 12 the the DT cord-263267-oj7rmy8m 44 13 treatment treatment NN cord-263267-oj7rmy8m 44 14 of of IN cord-263267-oj7rmy8m 44 15 COVID-19 COVID-19 NNP cord-263267-oj7rmy8m 44 16 Hydroxychloroquine Hydroxychloroquine NNP cord-263267-oj7rmy8m 44 17 and and CC cord-263267-oj7rmy8m 44 18 azithromycin azithromycin NNP cord-263267-oj7rmy8m 44 19 as as IN cord-263267-oj7rmy8m 44 20 a a DT cord-263267-oj7rmy8m 44 21 treatment treatment NN cord-263267-oj7rmy8m 44 22 of of IN cord-263267-oj7rmy8m 44 23 COVID-19 covid-19 NN cord-263267-oj7rmy8m 44 24 : : : cord-263267-oj7rmy8m 44 25 results result NNS cord-263267-oj7rmy8m 44 26 of of IN cord-263267-oj7rmy8m 44 27 an an DT cord-263267-oj7rmy8m 44 28 open open JJ cord-263267-oj7rmy8m 44 29 - - HYPH cord-263267-oj7rmy8m 44 30 label label NN cord-263267-oj7rmy8m 44 31 non non JJ cord-263267-oj7rmy8m 44 32 - - JJ cord-263267-oj7rmy8m 44 33 randomized randomized JJ cord-263267-oj7rmy8m 44 34 clinical clinical JJ cord-263267-oj7rmy8m 44 35 trial trial NN cord-263267-oj7rmy8m 44 36 Clinical clinical JJ cord-263267-oj7rmy8m 44 37 and and CC cord-263267-oj7rmy8m 44 38 microbiological microbiological JJ cord-263267-oj7rmy8m 44 39 effect effect NN cord-263267-oj7rmy8m 44 40 of of IN cord-263267-oj7rmy8m 44 41 a a DT cord-263267-oj7rmy8m 44 42 combination combination NN cord-263267-oj7rmy8m 44 43 of of IN cord-263267-oj7rmy8m 44 44 hydroxychloroquine hydroxychloroquine NN cord-263267-oj7rmy8m 44 45 and and CC cord-263267-oj7rmy8m 44 46 azithromycin azithromycin NNP cord-263267-oj7rmy8m 44 47 in in IN cord-263267-oj7rmy8m 44 48 80 80 CD cord-263267-oj7rmy8m 44 49 COVID-19 covid-19 JJ cord-263267-oj7rmy8m 44 50 patients patient NNS cord-263267-oj7rmy8m 44 51 with with IN cord-263267-oj7rmy8m 44 52 at at RB cord-263267-oj7rmy8m 44 53 least least JJS cord-263267-oj7rmy8m 44 54 a a DT cord-263267-oj7rmy8m 44 55 six six CD cord-263267-oj7rmy8m 44 56 - - HYPH cord-263267-oj7rmy8m 44 57 day day NN cord-263267-oj7rmy8m 44 58 follow follow VB cord-263267-oj7rmy8m 44 59 up up RP cord-263267-oj7rmy8m 44 60 : : : cord-263267-oj7rmy8m 44 61 an an DT cord-263267-oj7rmy8m 44 62 observational observational JJ cord-263267-oj7rmy8m 44 63 study study NN cord-263267-oj7rmy8m 44 64 Surviving Surviving NNP cord-263267-oj7rmy8m 44 65 Sepsis Sepsis NNP cord-263267-oj7rmy8m 44 66 Campaign Campaign NNP cord-263267-oj7rmy8m 44 67 : : : cord-263267-oj7rmy8m 44 68 guidelines guideline NNS cord-263267-oj7rmy8m 44 69 on on IN cord-263267-oj7rmy8m 44 70 the the DT cord-263267-oj7rmy8m 44 71 management management NN cord-263267-oj7rmy8m 44 72 of of IN cord-263267-oj7rmy8m 44 73 critically critically RB cord-263267-oj7rmy8m 44 74 ill ill JJ cord-263267-oj7rmy8m 44 75 adults adult NNS cord-263267-oj7rmy8m 44 76 with with IN cord-263267-oj7rmy8m 44 77 Coronavirus Coronavirus NNP cord-263267-oj7rmy8m 44 78 Disease Disease NNP cord-263267-oj7rmy8m 44 79 2019 2019 CD cord-263267-oj7rmy8m 45 1 ( ( -LRB- cord-263267-oj7rmy8m 45 2 COVID-19 covid-19 VB cord-263267-oj7rmy8m 45 3 ) ) -RRB- cord-263267-oj7rmy8m 45 4 Clinical clinical JJ cord-263267-oj7rmy8m 45 5 characteristics characteristic NNS cord-263267-oj7rmy8m 45 6 of of IN cord-263267-oj7rmy8m 45 7 coronavirus coronavirus NN cord-263267-oj7rmy8m 45 8 disease disease NN cord-263267-oj7rmy8m 45 9 2019 2019 CD cord-263267-oj7rmy8m 45 10 in in IN cord-263267-oj7rmy8m 45 11 China China NNP cord-263267-oj7rmy8m 46 1 A a DT cord-263267-oj7rmy8m 46 2 pilot pilot NN cord-263267-oj7rmy8m 46 3 study study NN cord-263267-oj7rmy8m 46 4 of of IN cord-263267-oj7rmy8m 46 5 hydroxychloroquine hydroxychloroquine NNP cord-263267-oj7rmy8m 46 6 in in IN cord-263267-oj7rmy8m 46 7 treatment treatment NN cord-263267-oj7rmy8m 46 8 of of IN cord-263267-oj7rmy8m 46 9 patients patient NNS cord-263267-oj7rmy8m 46 10 with with IN cord-263267-oj7rmy8m 46 11 common common JJ cord-263267-oj7rmy8m 46 12 coronavirus coronavirus NN cord-263267-oj7rmy8m 46 13 disease-19 disease-19 , cord-263267-oj7rmy8m 46 14 ( ( -LRB- cord-263267-oj7rmy8m 46 15 COVID-19 COVID-19 NNP cord-263267-oj7rmy8m 46 16 ) ) -RRB- cord-263267-oj7rmy8m 46 17 Efficacy Efficacy NNP cord-263267-oj7rmy8m 46 18 of of IN cord-263267-oj7rmy8m 46 19 hydroxychloroquine hydroxychloroquine NN cord-263267-oj7rmy8m 46 20 in in IN cord-263267-oj7rmy8m 46 21 patients patient NNS cord-263267-oj7rmy8m 46 22 with with IN cord-263267-oj7rmy8m 46 23 COVID-19 covid-19 NN cord-263267-oj7rmy8m 46 24 : : : cord-263267-oj7rmy8m 46 25 results result NNS cord-263267-oj7rmy8m 46 26 of of IN cord-263267-oj7rmy8m 46 27 a a DT cord-263267-oj7rmy8m 46 28 randomized randomized JJ cord-263267-oj7rmy8m 46 29 clinical clinical JJ cord-263267-oj7rmy8m 46 30 trial trial NN cord-263267-oj7rmy8m 47 1 No no DT cord-263267-oj7rmy8m 47 2 evidence evidence NN cord-263267-oj7rmy8m 47 3 of of IN cord-263267-oj7rmy8m 47 4 rapid rapid JJ cord-263267-oj7rmy8m 47 5 antiviral antiviral JJ cord-263267-oj7rmy8m 47 6 clearance clearance NN cord-263267-oj7rmy8m 47 7 or or CC cord-263267-oj7rmy8m 47 8 clinical clinical JJ cord-263267-oj7rmy8m 47 9 benefit benefit NN cord-263267-oj7rmy8m 47 10 with with IN cord-263267-oj7rmy8m 47 11 the the DT cord-263267-oj7rmy8m 47 12 combination combination NN cord-263267-oj7rmy8m 47 13 of of IN cord-263267-oj7rmy8m 47 14 hydroxychloroquine hydroxychloroquine NN cord-263267-oj7rmy8m 47 15 and and CC cord-263267-oj7rmy8m 47 16 azithromycin azithromycin NNP cord-263267-oj7rmy8m 47 17 in in IN cord-263267-oj7rmy8m 47 18 patients patient NNS cord-263267-oj7rmy8m 47 19 with with IN cord-263267-oj7rmy8m 47 20 severe severe JJ cord-263267-oj7rmy8m 47 21 COVID-19 covid-19 CD cord-263267-oj7rmy8m 47 22 infection infection NN