id sid tid token lemma pos cord-263258-qpzaehg0 1 1 key key JJ cord-263258-qpzaehg0 1 2 : : : cord-263258-qpzaehg0 1 3 cord-263258-qpzaehg0 cord-263258-qpzaehg0 NN cord-263258-qpzaehg0 1 4 authors author NNS cord-263258-qpzaehg0 1 5 : : : cord-263258-qpzaehg0 1 6 Montastruc Montastruc NNP cord-263258-qpzaehg0 1 7 , , , cord-263258-qpzaehg0 1 8 François François NNP cord-263258-qpzaehg0 1 9 ; ; : cord-263258-qpzaehg0 1 10 Thuriot Thuriot NNP cord-263258-qpzaehg0 1 11 , , , cord-263258-qpzaehg0 1 12 Samuel Samuel NNP cord-263258-qpzaehg0 1 13 ; ; : cord-263258-qpzaehg0 1 14 Durrieu Durrieu NNP cord-263258-qpzaehg0 1 15 , , , cord-263258-qpzaehg0 1 16 Geneviève Geneviève NNP cord-263258-qpzaehg0 1 17 title title NN cord-263258-qpzaehg0 1 18 : : : cord-263258-qpzaehg0 1 19 Hepatic hepatic JJ cord-263258-qpzaehg0 1 20 disorders disorder NNS cord-263258-qpzaehg0 1 21 with with IN cord-263258-qpzaehg0 1 22 the the DT cord-263258-qpzaehg0 1 23 use use NN cord-263258-qpzaehg0 1 24 of of IN cord-263258-qpzaehg0 1 25 remdesivir remdesivir NNP cord-263258-qpzaehg0 1 26 for for IN cord-263258-qpzaehg0 1 27 coronavirus coronavirus NNP cord-263258-qpzaehg0 1 28 2019 2019 CD cord-263258-qpzaehg0 1 29 ( ( -LRB- cord-263258-qpzaehg0 1 30 COVID-19 COVID-19 NNP cord-263258-qpzaehg0 1 31 ) ) -RRB- cord-263258-qpzaehg0 1 32 date date NN cord-263258-qpzaehg0 1 33 : : : cord-263258-qpzaehg0 1 34 2020 2020 CD cord-263258-qpzaehg0 1 35 - - HYPH cord-263258-qpzaehg0 1 36 07 07 CD cord-263258-qpzaehg0 1 37 - - HYPH cord-263258-qpzaehg0 1 38 25 25 CD cord-263258-qpzaehg0 1 39 journal journal NN cord-263258-qpzaehg0 1 40 : : : cord-263258-qpzaehg0 2 1 Clin Clin NNP cord-263258-qpzaehg0 2 2 Gastroenterol Gastroenterol NNP cord-263258-qpzaehg0 2 3 Hepatol Hepatol NNP cord-263258-qpzaehg0 2 4 DOI DOI NNP cord-263258-qpzaehg0 2 5 : : : cord-263258-qpzaehg0 2 6 10.1016 10.1016 CD cord-263258-qpzaehg0 2 7 / / SYM cord-263258-qpzaehg0 2 8 j.cgh.2020.07.050 j.cgh.2020.07.050 NNP cord-263258-qpzaehg0 2 9 sha sha NNP cord-263258-qpzaehg0 2 10 : : : cord-263258-qpzaehg0 2 11 65c63d665f492ae622524d5c9d74c5eb69ed588f 65c63d665f492ae622524d5c9d74c5eb69ed588f NNP cord-263258-qpzaehg0 2 12 doc_id doc_id CD cord-263258-qpzaehg0 2 13 : : : cord-263258-qpzaehg0 2 14 263258 263258 CD cord-263258-qpzaehg0 2 15 cord_uid cord_uid NNS cord-263258-qpzaehg0 2 16 : : : cord-263258-qpzaehg0 3 1 qpzaehg0 qpzaehg0 NN cord-263258-qpzaehg0 4 1 nan nan NNP cord-263258-qpzaehg0 4 2 Remdesivir Remdesivir NNP cord-263258-qpzaehg0 4 3 is be VBZ cord-263258-qpzaehg0 4 4 a a DT cord-263258-qpzaehg0 4 5 nucleotide nucleotide JJ cord-263258-qpzaehg0 4 6 analog analog NN cord-263258-qpzaehg0 4 7 prodrug prodrug NN cord-263258-qpzaehg0 4 8 with with IN cord-263258-qpzaehg0 4 9 antiviral antiviral JJ cord-263258-qpzaehg0 4 10 activity activity NN cord-263258-qpzaehg0 4 11 against against IN cord-263258-qpzaehg0 4 12 a a DT cord-263258-qpzaehg0 4 13 broad broad JJ cord-263258-qpzaehg0 4 14 spectrum spectrum NN cord-263258-qpzaehg0 4 15 of of IN cord-263258-qpzaehg0 4 16 human human JJ cord-263258-qpzaehg0 4 17 coronavirus coronavirus NN cord-263258-qpzaehg0 4 18 in in IN cord-263258-qpzaehg0 4 19 cell cell NN cord-263258-qpzaehg0 4 20 cultures culture NNS cord-263258-qpzaehg0 4 21 and and CC cord-263258-qpzaehg0 4 22 mouse mouse NN cord-263258-qpzaehg0 4 23 models model NNS cord-263258-qpzaehg0 4 24 including include VBG cord-263258-qpzaehg0 4 25 SARS SARS NNP cord-263258-qpzaehg0 4 26 - - HYPH cord-263258-qpzaehg0 4 27 CoV-2 CoV-2 NNP cord-263258-qpzaehg0 4 28 . . . cord-263258-qpzaehg0 5 1 Recently recently RB cord-263258-qpzaehg0 5 2 , , , cord-263258-qpzaehg0 5 3 the the DT cord-263258-qpzaehg0 5 4 Food Food NNP cord-263258-qpzaehg0 5 5 and and CC cord-263258-qpzaehg0 5 6 Drug Drug NNP cord-263258-qpzaehg0 5 7 Agency Agency NNP cord-263258-qpzaehg0 5 8 ( ( -LRB- cord-263258-qpzaehg0 5 9 FDA FDA NNP cord-263258-qpzaehg0 5 10 ) ) -RRB- cord-263258-qpzaehg0 5 11 and and CC cord-263258-qpzaehg0 5 12 the the DT cord-263258-qpzaehg0 5 13 European European NNP cord-263258-qpzaehg0 5 14 Medicines Medicines NNPS cord-263258-qpzaehg0 5 15 Agency Agency NNP cord-263258-qpzaehg0 5 16 ( ( -LRB- cord-263258-qpzaehg0 5 17 EMA EMA NNP cord-263258-qpzaehg0 5 18 ) ) -RRB- cord-263258-qpzaehg0 5 19 recommended recommend VBD cord-263258-qpzaehg0 5 20 remdesivir remdesivir NNP cord-263258-qpzaehg0 5 21 for for IN cord-263258-qpzaehg0 5 22 the the DT cord-263258-qpzaehg0 5 23 treatment treatment NN cord-263258-qpzaehg0 5 24 of of IN cord-263258-qpzaehg0 5 25 patients patient NNS cord-263258-qpzaehg0 5 26 hospitalized hospitalize VBN cord-263258-qpzaehg0 5 27 with with IN cord-263258-qpzaehg0 5 28 severe severe JJ cord-263258-qpzaehg0 5 29 COVID-19 covid-19 JJ cord-263258-qpzaehg0 5 30 infection infection NN cord-263258-qpzaehg0 5 31 . . . cord-263258-qpzaehg0 6 1 1 1 CD cord-263258-qpzaehg0 6 2 , , , cord-263258-qpzaehg0 6 3 2 2 CD cord-263258-qpzaehg0 7 1 In in IN cord-263258-qpzaehg0 7 2 the the DT cord-263258-qpzaehg0 7 3 remdesivir remdesivir NNP cord-263258-qpzaehg0 7 4 clinical clinical JJ cord-263258-qpzaehg0 7 5 development development NNP cord-263258-qpzaehg0 7 6 program program NN cord-263258-qpzaehg0 7 7 , , , cord-263258-qpzaehg0 7 8 some some DT cord-263258-qpzaehg0 7 9 cases case NNS cord-263258-qpzaehg0 7 10 have have VBP cord-263258-qpzaehg0 7 11 raised raise VBN cord-263258-qpzaehg0 7 12 concerns concern NNS cord-263258-qpzaehg0 7 13 regarding regard VBG cord-263258-qpzaehg0 7 14 a a DT cord-263258-qpzaehg0 7 15 potential potential JJ cord-263258-qpzaehg0 7 16 hepato hepato JJ cord-263258-qpzaehg0 7 17 - - HYPH cord-263258-qpzaehg0 7 18 biliary biliary JJ cord-263258-qpzaehg0 7 19 disorders disorder NNS cord-263258-qpzaehg0 7 20 associated associate VBN cord-263258-qpzaehg0 7 21 with with IN cord-263258-qpzaehg0 7 22 remdesivir remdesivir NNP cord-263258-qpzaehg0 7 23 , , , cord-263258-qpzaehg0 7 24 including include VBG cord-263258-qpzaehg0 7 25 in in IN cord-263258-qpzaehg0 7 26 healthy healthy JJ cord-263258-qpzaehg0 7 27 volunteers volunteer NNS cord-263258-qpzaehg0 7 28 and and CC cord-263258-qpzaehg0 7 29 patients patient NNS cord-263258-qpzaehg0 7 30 with with IN cord-263258-qpzaehg0 7 31 COVID-19 COVID-19 NNP cord-263258-qpzaehg0 7 32 . . . cord-263258-qpzaehg0 7 33 3 3 CD cord-263258-qpzaehg0 8 1 In in IN cord-263258-qpzaehg0 8 2 cohort cohort NN cord-263258-qpzaehg0 8 3 studies study NNS cord-263258-qpzaehg0 8 4 of of IN cord-263258-qpzaehg0 8 5 patients patient NNS cord-263258-qpzaehg0 8 6 hospitalized hospitalize VBN cord-263258-qpzaehg0 8 7 for for IN cord-263258-qpzaehg0 8 8 severe severe JJ cord-263258-qpzaehg0 8 9 COVID-19 covid-19 NN cord-263258-qpzaehg0 8 10 who who WP cord-263258-qpzaehg0 8 11 were be VBD cord-263258-qpzaehg0 8 12 treated treat VBN cord-263258-qpzaehg0 8 13 with with IN cord-263258-qpzaehg0 8 14 compassionate compassionate JJ cord-263258-qpzaehg0 8 15 - - HYPH cord-263258-qpzaehg0 8 16 use use NN cord-263258-qpzaehg0 8 17 remdesivir remdesivir NNS cord-263258-qpzaehg0 8 18 , , , cord-263258-qpzaehg0 8 19 hepatic hepatic JJ cord-263258-qpzaehg0 8 20 enzyme enzyme NN cord-263258-qpzaehg0 8 21 elevated elevate VBN cord-263258-qpzaehg0 8 22 were be VBD cord-263258-qpzaehg0 8 23 the the DT cord-263258-qpzaehg0 8 24 most most RBS cord-263258-qpzaehg0 8 25 frequent frequent JJ cord-263258-qpzaehg0 8 26 adverse adverse JJ cord-263258-qpzaehg0 8 27 drug drug NN cord-263258-qpzaehg0 8 28 reaction reaction NN cord-263258-qpzaehg0 8 29 reported report VBD cord-263258-qpzaehg0 8 30 . . . cord-263258-qpzaehg0 9 1 4 4 LS cord-263258-qpzaehg0 9 2 , , , cord-263258-qpzaehg0 9 3 5 5 CD cord-263258-qpzaehg0 10 1 In in IN cord-263258-qpzaehg0 10 2 the the DT cord-263258-qpzaehg0 10 3 first first JJ cord-263258-qpzaehg0 10 4 randomized randomized JJ cord-263258-qpzaehg0 10 5 , , , cord-263258-qpzaehg0 10 6 double double JJ cord-263258-qpzaehg0 10 7 - - HYPH cord-263258-qpzaehg0 10 8 blind blind JJ cord-263258-qpzaehg0 10 9 , , , cord-263258-qpzaehg0 10 10 placebo placebo NN cord-263258-qpzaehg0 10 11 - - HYPH cord-263258-qpzaehg0 10 12 controlled control VBN cord-263258-qpzaehg0 10 13 clinical clinical JJ cord-263258-qpzaehg0 10 14 trial trial NN cord-263258-qpzaehg0 10 15 assessing assess VBG cord-263258-qpzaehg0 10 16 the the DT cord-263258-qpzaehg0 10 17 effect effect NN cord-263258-qpzaehg0 10 18 of of IN cord-263258-qpzaehg0 10 19 intravenous intravenous JJ cord-263258-qpzaehg0 10 20 remdesivir remdesivir NNS cord-263258-qpzaehg0 10 21 in in IN cord-263258-qpzaehg0 10 22 adults adult NNS cord-263258-qpzaehg0 10 23 admitted admit VBN cord-263258-qpzaehg0 10 24 to to IN cord-263258-qpzaehg0 10 25 hospital hospital NN cord-263258-qpzaehg0 10 26 with with IN cord-263258-qpzaehg0 10 27 severe severe JJ cord-263258-qpzaehg0 10 28 COVID-19 covid-19 NN cord-263258-qpzaehg0 11 1 ( ( -LRB- cord-263258-qpzaehg0 11 2 n= n= NNP cord-263258-qpzaehg0 11 3 237 237 CD cord-263258-qpzaehg0 11 4 ) ) -RRB- cord-263258-qpzaehg0 12 1 a a DT cord-263258-qpzaehg0 12 2 higher high JJR cord-263258-qpzaehg0 12 3 proportion proportion NN cord-263258-qpzaehg0 12 4 of of IN cord-263258-qpzaehg0 12 5 remdesivir remdesivir JJ cord-263258-qpzaehg0 12 6 recipients recipient NNS cord-263258-qpzaehg0 12 7 than than IN cord-263258-qpzaehg0 12 8 placebo placebo NN cord-263258-qpzaehg0 12 9 recipients recipient NNS cord-263258-qpzaehg0 12 10 had have VBD cord-263258-qpzaehg0 12 11 dosing dose VBG cord-263258-qpzaehg0 12 12 prematurely prematurely RB cord-263258-qpzaehg0 12 13 stopped stop VBN cord-263258-qpzaehg0 12 14 by by IN cord-263258-qpzaehg0 12 15 the the DT cord-263258-qpzaehg0 12 16 investigators investigator NNS cord-263258-qpzaehg0 12 17 because because IN cord-263258-qpzaehg0 12 18 of of IN cord-263258-qpzaehg0 12 19 adverse adverse JJ cord-263258-qpzaehg0 12 20 events event NNS cord-263258-qpzaehg0 12 21 including include VBG cord-263258-qpzaehg0 12 22 aminotransferase aminotransferase NN cord-263258-qpzaehg0 12 23 or or CC cord-263258-qpzaehg0 12 24 bilirubin bilirubin NN cord-263258-qpzaehg0 12 25 increases increase NNS cord-263258-qpzaehg0 12 26 ( ( -LRB- cord-263258-qpzaehg0 12 27 3 3 CD cord-263258-qpzaehg0 12 28 versus versus IN cord-263258-qpzaehg0 12 29 0 0 CD cord-263258-qpzaehg0 12 30 ) ) -RRB- cord-263258-qpzaehg0 12 31 . . . cord-263258-qpzaehg0 13 1 6 6 CD cord-263258-qpzaehg0 14 1 Although although IN cord-263258-qpzaehg0 14 2 there there EX cord-263258-qpzaehg0 14 3 is be VBZ cord-263258-qpzaehg0 14 4 no no DT cord-263258-qpzaehg0 14 5 signal signal NN cord-263258-qpzaehg0 14 6 from from IN cord-263258-qpzaehg0 14 7 the the DT cord-263258-qpzaehg0 14 8 available available JJ cord-263258-qpzaehg0 14 9 data datum NNS cord-263258-qpzaehg0 14 10 of of IN cord-263258-qpzaehg0 14 11 severe severe JJ cord-263258-qpzaehg0 14 12 hepatotoxicity hepatotoxicity NN cord-263258-qpzaehg0 14 13 or or CC cord-263258-qpzaehg0 14 14 Drug drug NN cord-263258-qpzaehg0 14 15 - - HYPH cord-263258-qpzaehg0 14 16 Induced Induced NNP cord-263258-qpzaehg0 14 17 Liver Liver NNP cord-263258-qpzaehg0 14 18 Injury injury NN cord-263258-qpzaehg0 14 19 ( ( -LRB- cord-263258-qpzaehg0 14 20 DILI DILI NNP cord-263258-qpzaehg0 14 21 ) ) -RRB- cord-263258-qpzaehg0 14 22 in in IN cord-263258-qpzaehg0 14 23 clinical clinical JJ cord-263258-qpzaehg0 14 24 trials trial NNS cord-263258-qpzaehg0 14 25 , , , cord-263258-qpzaehg0 14 26 the the DT cord-263258-qpzaehg0 14 27 number number NN cord-263258-qpzaehg0 14 28 of of IN cord-263258-qpzaehg0 14 29 patients patient NNS cord-263258-qpzaehg0 14 30 exposed expose VBN cord-263258-qpzaehg0 14 31 to to IN cord-263258-qpzaehg0 14 32 remdesivir remdesivir NNP cord-263258-qpzaehg0 14 33 was be VBD cord-263258-qpzaehg0 14 34 too too RB cord-263258-qpzaehg0 14 35 limited limited JJ cord-263258-qpzaehg0 14 36 . . . cord-263258-qpzaehg0 15 1 Therefore therefore RB cord-263258-qpzaehg0 15 2 , , , cord-263258-qpzaehg0 15 3 there there EX cord-263258-qpzaehg0 15 4 is be VBZ cord-263258-qpzaehg0 15 5 an an DT cord-263258-qpzaehg0 15 6 urgent urgent JJ cord-263258-qpzaehg0 15 7 need need NN cord-263258-qpzaehg0 15 8 to to TO cord-263258-qpzaehg0 15 9 investigate investigate VB cord-263258-qpzaehg0 15 10 the the DT cord-263258-qpzaehg0 15 11 hepatic hepatic JJ cord-263258-qpzaehg0 15 12 safety safety NN cord-263258-qpzaehg0 15 13 profile profile NN cord-263258-qpzaehg0 15 14 associated associate VBN cord-263258-qpzaehg0 15 15 with with IN cord-263258-qpzaehg0 15 16 remdesivir remdesivir NNP cord-263258-qpzaehg0 15 17 in in IN cord-263258-qpzaehg0 15 18 COVID-19 COVID-19 NNP cord-263258-qpzaehg0 15 19 patients patient NNS cord-263258-qpzaehg0 15 20 . . . cord-263258-qpzaehg0 16 1 Here here RB cord-263258-qpzaehg0 16 2 , , , cord-263258-qpzaehg0 16 3 we -PRON- PRP cord-263258-qpzaehg0 16 4 performed perform VBD cord-263258-qpzaehg0 16 5 a a DT cord-263258-qpzaehg0 16 6 pharmacovigilance pharmacovigilance NN cord-263258-qpzaehg0 16 7 analysis analysis NN cord-263258-qpzaehg0 16 8 of of IN cord-263258-qpzaehg0 16 9 VigiBase VigiBase NNP cord-263258-qpzaehg0 16 10 , , , cord-263258-qpzaehg0 16 11 the the DT cord-263258-qpzaehg0 16 12 World World NNP cord-263258-qpzaehg0 16 13 Health Health NNP cord-263258-qpzaehg0 16 14 Organization Organization NNP cord-263258-qpzaehg0 16 15 's 's POS cord-263258-qpzaehg0 16 16 individual individual JJ cord-263258-qpzaehg0 16 17 case case NN cord-263258-qpzaehg0 16 18 safety safety NN cord-263258-qpzaehg0 16 19 reports report NNS cord-263258-qpzaehg0 16 20 database database NN cord-263258-qpzaehg0 16 21 , , , cord-263258-qpzaehg0 16 22 to to TO cord-263258-qpzaehg0 16 23 describe describe VB cord-263258-qpzaehg0 16 24 hepatic hepatic JJ cord-263258-qpzaehg0 16 25 impairment impairment NN cord-263258-qpzaehg0 16 26 reports report NNS cord-263258-qpzaehg0 16 27 with with IN cord-263258-qpzaehg0 16 28 remdesivir remdesivir NNP cord-263258-qpzaehg0 16 29 . . . cord-263258-qpzaehg0 17 1 7 7 CD cord-263258-qpzaehg0 17 2 VigiBase VigiBase NNP cord-263258-qpzaehg0 17 3 contains contain VBZ cord-263258-qpzaehg0 17 4 more more JJR cord-263258-qpzaehg0 17 5 than than IN cord-263258-qpzaehg0 17 6 22 22 CD cord-263258-qpzaehg0 17 7 million million CD cord-263258-qpzaehg0 17 8 spontaneous spontaneous JJ cord-263258-qpzaehg0 17 9 generated generate VBD cord-263258-qpzaehg0 17 10 adverse adverse JJ cord-263258-qpzaehg0 17 11 drug drug NN cord-263258-qpzaehg0 17 12 reactions reaction NNS cord-263258-qpzaehg0 17 13 , , , cord-263258-qpzaehg0 17 14 from from IN cord-263258-qpzaehg0 17 15 136 136 CD cord-263258-qpzaehg0 17 16 countries country NNS cord-263258-qpzaehg0 17 17 , , , cord-263258-qpzaehg0 17 18 covering cover VBG cord-263258-qpzaehg0 17 19 more more JJR cord-263258-qpzaehg0 17 20 than than IN cord-263258-qpzaehg0 17 21 90 90 CD cord-263258-qpzaehg0 17 22 % % NN cord-263258-qpzaehg0 17 23 of of IN cord-263258-qpzaehg0 17 24 the the DT cord-263258-qpzaehg0 17 25 world world NN cord-263258-qpzaehg0 17 26 's 's POS cord-263258-qpzaehg0 17 27 population population NN cord-263258-qpzaehg0 17 28 . . . cord-263258-qpzaehg0 18 1 VigiBase VigiBase NNP cord-263258-qpzaehg0 18 2 includes include VBZ cord-263258-qpzaehg0 18 3 information information NN cord-263258-qpzaehg0 18 4 on on IN cord-263258-qpzaehg0 18 5 patient patient JJ cord-263258-qpzaehg0 18 6 , , , cord-263258-qpzaehg0 18 7 medical medical JJ cord-263258-qpzaehg0 18 8 history history NN cord-263258-qpzaehg0 18 9 , , , cord-263258-qpzaehg0 18 10 country country NN cord-263258-qpzaehg0 18 11 , , , cord-263258-qpzaehg0 18 12 drugs drug NNS cord-263258-qpzaehg0 18 13 taken take VBN cord-263258-qpzaehg0 18 14 with with IN cord-263258-qpzaehg0 18 15 their -PRON- PRP$ cord-263258-qpzaehg0 18 16 initiation initiation NN cord-263258-qpzaehg0 18 17 and and CC cord-263258-qpzaehg0 18 18 stop stop VB cord-263258-qpzaehg0 18 19 date date NN cord-263258-qpzaehg0 18 20 . . . cord-263258-qpzaehg0 19 1 We -PRON- PRP cord-263258-qpzaehg0 19 2 considered consider VBD cord-263258-qpzaehg0 19 3 only only RB cord-263258-qpzaehg0 19 4 reports report NNS cord-263258-qpzaehg0 19 5 of of IN cord-263258-qpzaehg0 19 6 patients patient NNS cord-263258-qpzaehg0 19 7 with with IN cord-263258-qpzaehg0 19 8 COVID-19 COVID-19 NNP cord-263258-qpzaehg0 19 9 registered register VBN cord-263258-qpzaehg0 19 10 up up RP cord-263258-qpzaehg0 19 11 to to IN cord-263258-qpzaehg0 19 12 the the DT cord-263258-qpzaehg0 19 13 15 15 CD cord-263258-qpzaehg0 19 14 th th CD cord-263258-qpzaehg0 19 15 of of IN cord-263258-qpzaehg0 19 16 June June NNP cord-263258-qpzaehg0 19 17 2020 2020 CD cord-263258-qpzaehg0 19 18 . . . cord-263258-qpzaehg0 20 1 Disproportionality Disproportionality NNP cord-263258-qpzaehg0 20 2 analysis analysis NN cord-263258-qpzaehg0 20 3 was be VBD cord-263258-qpzaehg0 20 4 performed perform VBN cord-263258-qpzaehg0 20 5 to to TO cord-263258-qpzaehg0 20 6 assess assess VB cord-263258-qpzaehg0 20 7 a a DT cord-263258-qpzaehg0 20 8 potential potential JJ cord-263258-qpzaehg0 20 9 increased increase VBN cord-263258-qpzaehg0 20 10 risk risk NN cord-263258-qpzaehg0 20 11 of of IN cord-263258-qpzaehg0 20 12 reporting report VBG cord-263258-qpzaehg0 20 13 hepatic hepatic JJ cord-263258-qpzaehg0 20 14 disorders disorder NNS cord-263258-qpzaehg0 20 15 with with IN cord-263258-qpzaehg0 20 16 remdesivir remdesivir NNS cord-263258-qpzaehg0 20 17 compared compare VBN cord-263258-qpzaehg0 20 18 to to IN cord-263258-qpzaehg0 20 19 drugs drug NNS cord-263258-qpzaehg0 20 20 prescribed prescribe VBN cord-263258-qpzaehg0 20 21 in in IN cord-263258-qpzaehg0 20 22 COVID-19 COVID-19 NNP cord-263258-qpzaehg0 20 23 patients patient NNS cord-263258-qpzaehg0 20 24 . . . cord-263258-qpzaehg0 21 1 8 8 CD cord-263258-qpzaehg0 22 1 The the DT cord-263258-qpzaehg0 22 2 risk risk NN cord-263258-qpzaehg0 22 3 of of IN cord-263258-qpzaehg0 22 4 hepatic hepatic JJ cord-263258-qpzaehg0 22 5 disorders disorder NNS cord-263258-qpzaehg0 22 6 was be VBD cord-263258-qpzaehg0 22 7 calculated calculate VBN cord-263258-qpzaehg0 22 8 using use VBG cord-263258-qpzaehg0 22 9 the the DT cord-263258-qpzaehg0 22 10 Reporting Reporting NNP cord-263258-qpzaehg0 22 11 Odds Odds NNPS cord-263258-qpzaehg0 22 12 Ratios Ratios NNP cord-263258-qpzaehg0 22 13 ( ( -LRB- cord-263258-qpzaehg0 22 14 ROR ROR NNP cord-263258-qpzaehg0 22 15 ) ) -RRB- cord-263258-qpzaehg0 22 16 with with IN cord-263258-qpzaehg0 22 17 their -PRON- PRP$ cord-263258-qpzaehg0 22 18 95 95 CD cord-263258-qpzaehg0 22 19 % % NN cord-263258-qpzaehg0 22 20 confidence confidence NN cord-263258-qpzaehg0 22 21 interval interval NN cord-263258-qpzaehg0 22 22 ( ( -LRB- cord-263258-qpzaehg0 22 23 CI CI NNP cord-263258-qpzaehg0 22 24 ) ) -RRB- cord-263258-qpzaehg0 22 25 , , , cord-263258-qpzaehg0 22 26 a a DT cord-263258-qpzaehg0 22 27 ratio ratio NN cord-263258-qpzaehg0 22 28 similar similar JJ cord-263258-qpzaehg0 22 29 in in IN cord-263258-qpzaehg0 22 30 concept concept NN cord-263258-qpzaehg0 22 31 to to IN cord-263258-qpzaehg0 22 32 the the DT cord-263258-qpzaehg0 22 33 Odds Odds NNPS cord-263258-qpzaehg0 22 34 Ratio Ratio NNP cord-263258-qpzaehg0 22 35 in in IN cord-263258-qpzaehg0 22 36 case case NN cord-263258-qpzaehg0 22 37 - - HYPH cord-263258-qpzaehg0 22 38 control control NN cord-263258-qpzaehg0 22 39 studies study NNS cord-263258-qpzaehg0 22 40 .. .. . cord-263258-qpzaehg0 23 1 To to TO cord-263258-qpzaehg0 23 2 minimize minimize VB cord-263258-qpzaehg0 23 3 the the DT cord-263258-qpzaehg0 23 4 potential potential NN cord-263258-qpzaehg0 23 5 of of IN cord-263258-qpzaehg0 23 6 confounding confound VBG cord-263258-qpzaehg0 23 7 by by IN cord-263258-qpzaehg0 23 8 disease disease NN cord-263258-qpzaehg0 23 9 severity severity NN cord-263258-qpzaehg0 23 10 ( ( -LRB- cord-263258-qpzaehg0 23 11 hepatic hepatic JJ cord-263258-qpzaehg0 23 12 disorders disorder NNS cord-263258-qpzaehg0 23 13 could could MD cord-263258-qpzaehg0 23 14 be be VB cord-263258-qpzaehg0 23 15 associated associate VBN cord-263258-qpzaehg0 23 16 with with IN cord-263258-qpzaehg0 23 17 the the DT cord-263258-qpzaehg0 23 18 severity severity NN cord-263258-qpzaehg0 23 19 of of IN cord-263258-qpzaehg0 23 20 COVID-19 covid-19 JJ cord-263258-qpzaehg0 23 21 infection infection NN cord-263258-qpzaehg0 23 22 ) ) -RRB- cord-263258-qpzaehg0 23 23 , , , cord-263258-qpzaehg0 23 24 we -PRON- PRP cord-263258-qpzaehg0 23 25 repeated repeat VBD cord-263258-qpzaehg0 23 26 the the DT cord-263258-qpzaehg0 23 27 primary primary JJ cord-263258-qpzaehg0 23 28 analysis analysis NN cord-263258-qpzaehg0 23 29 considering consider VBG cord-263258-qpzaehg0 23 30 only only RB cord-263258-qpzaehg0 23 31 users user NNS cord-263258-qpzaehg0 23 32 of of IN cord-263258-qpzaehg0 23 33 tocilizumab tocilizumab NNP cord-263258-qpzaehg0 23 34 , , , cord-263258-qpzaehg0 23 35 a a DT cord-263258-qpzaehg0 23 36 drug drug NN cord-263258-qpzaehg0 23 37 recommended recommend VBN cord-263258-qpzaehg0 23 38 in in IN cord-263258-qpzaehg0 23 39 severe severe JJ cord-263258-qpzaehg0 23 40 COVID-19 covid-19 JJ cord-263258-qpzaehg0 23 41 cases case NNS cord-263258-qpzaehg0 23 42 . . . cord-263258-qpzaehg0 24 1 We -PRON- PRP cord-263258-qpzaehg0 24 2 found find VBD cord-263258-qpzaehg0 24 3 387 387 CD cord-263258-qpzaehg0 24 4 reports report NNS cord-263258-qpzaehg0 24 5 with with IN cord-263258-qpzaehg0 24 6 remdesivir remdesivir NNP cord-263258-qpzaehg0 24 7 registered register VBN cord-263258-qpzaehg0 24 8 in in IN cord-263258-qpzaehg0 24 9 VigiBase VigiBase NNP cord-263258-qpzaehg0 24 10 , , , cord-263258-qpzaehg0 24 11 and and CC cord-263258-qpzaehg0 24 12 among among IN cord-263258-qpzaehg0 24 13 them -PRON- PRP cord-263258-qpzaehg0 24 14 130 130 CD cord-263258-qpzaehg0 24 15 hepatic hepatic JJ cord-263258-qpzaehg0 24 16 adverse adverse JJ cord-263258-qpzaehg0 24 17 effects effect NNS cord-263258-qpzaehg0 24 18 were be VBD cord-263258-qpzaehg0 24 19 reported report VBN cord-263258-qpzaehg0 24 20 ( ( -LRB- cord-263258-qpzaehg0 24 21 34 34 CD cord-263258-qpzaehg0 24 22 % % NN cord-263258-qpzaehg0 24 23 ) ) -RRB- cord-263258-qpzaehg0 24 24 . . . cord-263258-qpzaehg0 25 1 Reports report NNS cord-263258-qpzaehg0 25 2 originated originate VBD cord-263258-qpzaehg0 25 3 from from IN cord-263258-qpzaehg0 25 4 US US NNP cord-263258-qpzaehg0 25 5 ( ( -LRB- cord-263258-qpzaehg0 25 6 87 87 CD cord-263258-qpzaehg0 25 7 ) ) -RRB- cord-263258-qpzaehg0 25 8 and and CC cord-263258-qpzaehg0 25 9 Europe Europe NNP cord-263258-qpzaehg0 25 10 ( ( -LRB- cord-263258-qpzaehg0 25 11 43 43 CD cord-263258-qpzaehg0 25 12 ) ) -RRB- cord-263258-qpzaehg0 25 13 , , , cord-263258-qpzaehg0 25 14 involving involve VBG cord-263258-qpzaehg0 25 15 mostly mostly RB cord-263258-qpzaehg0 25 16 men man NNS cord-263258-qpzaehg0 25 17 ( ( -LRB- cord-263258-qpzaehg0 25 18 81 81 CD cord-263258-qpzaehg0 25 19 , , , cord-263258-qpzaehg0 25 20 62 62 CD cord-263258-qpzaehg0 25 21 % % NN cord-263258-qpzaehg0 25 22 ) ) -RRB- cord-263258-qpzaehg0 25 23 , , , cord-263258-qpzaehg0 25 24 with with IN cord-263258-qpzaehg0 25 25 a a DT cord-263258-qpzaehg0 25 26 mean mean JJ cord-263258-qpzaehg0 25 27 age age NN cord-263258-qpzaehg0 25 28 of of IN cord-263258-qpzaehg0 25 29 54·9 54·9 CD cord-263258-qpzaehg0 25 30 years year NNS cord-263258-qpzaehg0 25 31 ( ( -LRB- cord-263258-qpzaehg0 25 32 min min NNP cord-263258-qpzaehg0 25 33 2 2 CD cord-263258-qpzaehg0 25 34 , , , cord-263258-qpzaehg0 25 35 max max NNP cord-263258-qpzaehg0 25 36 92 92 CD cord-263258-qpzaehg0 25 37 ) ) -RRB- cord-263258-qpzaehg0 25 38 . . . cord-263258-qpzaehg0 26 1 Treatment treatment NN cord-263258-qpzaehg0 26 2 duration duration NN cord-263258-qpzaehg0 26 3 with with IN cord-263258-qpzaehg0 26 4 remdesivir remdesivir NNP cord-263258-qpzaehg0 26 5 varied vary VBN cord-263258-qpzaehg0 26 6 between between IN cord-263258-qpzaehg0 26 7 1 1 CD cord-263258-qpzaehg0 26 8 day day NN cord-263258-qpzaehg0 26 9 ( ( -LRB- cord-263258-qpzaehg0 26 10 15 15 CD cord-263258-qpzaehg0 26 11 discontinuations discontinuation NNS cord-263258-qpzaehg0 26 12 for for IN cord-263258-qpzaehg0 26 13 serious serious JJ cord-263258-qpzaehg0 26 14 adverse adverse JJ cord-263258-qpzaehg0 26 15 effects effect NNS cord-263258-qpzaehg0 26 16 ) ) -RRB- cord-263258-qpzaehg0 26 17 and and CC cord-263258-qpzaehg0 26 18 11 11 CD cord-263258-qpzaehg0 26 19 days day NNS cord-263258-qpzaehg0 26 20 , , , cord-263258-qpzaehg0 26 21 with with IN cord-263258-qpzaehg0 26 22 a a DT cord-263258-qpzaehg0 26 23 mean mean JJ cord-263258-qpzaehg0 26 24 duration duration NN cord-263258-qpzaehg0 26 25 of of IN cord-263258-qpzaehg0 26 26 3.8 3.8 CD cord-263258-qpzaehg0 26 27 days day NNS cord-263258-qpzaehg0 26 28 . . . cord-263258-qpzaehg0 27 1 In in IN cord-263258-qpzaehg0 27 2 the the DT cord-263258-qpzaehg0 27 3 majority majority NN cord-263258-qpzaehg0 27 4 of of IN cord-263258-qpzaehg0 27 5 cases case NNS cord-263258-qpzaehg0 27 6 ( ( -LRB- cord-263258-qpzaehg0 27 7 122 122 CD cord-263258-qpzaehg0 27 8 , , , cord-263258-qpzaehg0 27 9 94 94 CD cord-263258-qpzaehg0 27 10 % % NN cord-263258-qpzaehg0 27 11 ) ) -RRB- cord-263258-qpzaehg0 27 12 , , , cord-263258-qpzaehg0 27 13 remdesivir remdesivir NNP cord-263258-qpzaehg0 27 14 was be VBD cord-263258-qpzaehg0 27 15 the the DT cord-263258-qpzaehg0 27 16 sole sole JJ cord-263258-qpzaehg0 27 17 suspected suspect VBN cord-263258-qpzaehg0 27 18 drug drug NN cord-263258-qpzaehg0 27 19 . . . cord-263258-qpzaehg0 28 1 Most Most JJS cord-263258-qpzaehg0 28 2 of of IN cord-263258-qpzaehg0 28 3 cases case NNS cord-263258-qpzaehg0 28 4 were be VBD cord-263258-qpzaehg0 28 5 serious serious JJ cord-263258-qpzaehg0 28 6 ( ( -LRB- cord-263258-qpzaehg0 28 7 94 94 CD cord-263258-qpzaehg0 28 8 , , , cord-263258-qpzaehg0 28 9 72 72 CD cord-263258-qpzaehg0 28 10 % % NN cord-263258-qpzaehg0 28 11 ) ) -RRB- cord-263258-qpzaehg0 28 12 ( ( -LRB- cord-263258-qpzaehg0 28 13 i.e. i.e. FW cord-263258-qpzaehg0 28 14 resulting result VBG cord-263258-qpzaehg0 28 15 in in IN cord-263258-qpzaehg0 28 16 hospitalization hospitalization NN cord-263258-qpzaehg0 28 17 or or CC cord-263258-qpzaehg0 28 18 prolongation prolongation NN cord-263258-qpzaehg0 28 19 of of IN cord-263258-qpzaehg0 28 20 hospital hospital NN cord-263258-qpzaehg0 28 21 stay stay NN cord-263258-qpzaehg0 28 22 ) ) -RRB- cord-263258-qpzaehg0 28 23 . . . cord-263258-qpzaehg0 29 1 The the DT cord-263258-qpzaehg0 29 2 mean mean JJ cord-263258-qpzaehg0 29 3 time time NN cord-263258-qpzaehg0 29 4 to to IN cord-263258-qpzaehg0 29 5 onset onset VB cord-263258-qpzaehg0 29 6 hepatic hepatic JJ cord-263258-qpzaehg0 29 7 disorders disorder NNS cord-263258-qpzaehg0 29 8 was be VBD cord-263258-qpzaehg0 29 9 5.4 5.4 CD cord-263258-qpzaehg0 29 10 days day NNS cord-263258-qpzaehg0 29 11 . . . cord-263258-qpzaehg0 30 1 Hepatic hepatic JJ cord-263258-qpzaehg0 30 2 enzymes enzyme NNS cord-263258-qpzaehg0 30 3 increased increase VBD cord-263258-qpzaehg0 30 4 were be VBD cord-263258-qpzaehg0 30 5 the the DT cord-263258-qpzaehg0 30 6 most most RBS cord-263258-qpzaehg0 30 7 frequent frequent JJ cord-263258-qpzaehg0 30 8 adverse adverse JJ cord-263258-qpzaehg0 30 9 drug drug NN cord-263258-qpzaehg0 30 10 reactions reaction NNS cord-263258-qpzaehg0 30 11 reported report VBN cord-263258-qpzaehg0 30 12 ( ( -LRB- cord-263258-qpzaehg0 30 13 114 114 CD cord-263258-qpzaehg0 30 14 , , , cord-263258-qpzaehg0 30 15 88 88 CD cord-263258-qpzaehg0 30 16 % % NN cord-263258-qpzaehg0 30 17 ) ) -RRB- cord-263258-qpzaehg0 30 18 involving involve VBG cord-263258-qpzaehg0 30 19 the the DT cord-263258-qpzaehg0 30 20 liver liver NN cord-263258-qpzaehg0 30 21 transaminases transaminase NNS cord-263258-qpzaehg0 30 22 ( ( -LRB- cord-263258-qpzaehg0 30 23 aspartate aspartate NN cord-263258-qpzaehg0 30 24 transaminase transaminase NN cord-263258-qpzaehg0 30 25 and and CC cord-263258-qpzaehg0 30 26 alanine alanine NN cord-263258-qpzaehg0 30 27 transaminase transaminase FW cord-263258-qpzaehg0 30 28 ) ) -RRB- cord-263258-qpzaehg0 30 29 in in IN cord-263258-qpzaehg0 30 30 79 79 CD cord-263258-qpzaehg0 30 31 cases case NNS cord-263258-qpzaehg0 30 32 ( ( -LRB- cord-263258-qpzaehg0 30 33 61 61 CD cord-263258-qpzaehg0 30 34 % % NN cord-263258-qpzaehg0 30 35 ) ) -RRB- cord-263258-qpzaehg0 30 36 and and CC cord-263258-qpzaehg0 30 37 bilirubin bilirubin NN cord-263258-qpzaehg0 30 38 in in IN cord-263258-qpzaehg0 30 39 4 4 CD cord-263258-qpzaehg0 30 40 cases case NNS cord-263258-qpzaehg0 30 41 ( ( -LRB- cord-263258-qpzaehg0 30 42 3 3 CD cord-263258-qpzaehg0 30 43 % % NN cord-263258-qpzaehg0 30 44 ) ) -RRB- cord-263258-qpzaehg0 30 45 . . . cord-263258-qpzaehg0 31 1 Other other JJ cord-263258-qpzaehg0 31 2 cases case NNS cord-263258-qpzaehg0 31 3 were be VBD cord-263258-qpzaehg0 31 4 reported report VBN cord-263258-qpzaehg0 31 5 as as IN cord-263258-qpzaehg0 31 6 hepatic hepatic JJ cord-263258-qpzaehg0 31 7 failure failure NN cord-263258-qpzaehg0 31 8 or or CC cord-263258-qpzaehg0 31 9 hepatitis hepatitis NN cord-263258-qpzaehg0 31 10 . . . cord-263258-qpzaehg0 32 1 Compared compare VBN cord-263258-qpzaehg0 32 2 with with IN cord-263258-qpzaehg0 32 3 hydroxychloroquine hydroxychloroquine NNP cord-263258-qpzaehg0 32 4 , , , cord-263258-qpzaehg0 32 5 lopinavir lopinavir NNP cord-263258-qpzaehg0 32 6 / / SYM cord-263258-qpzaehg0 32 7 ritonavir ritonavir NNP cord-263258-qpzaehg0 32 8 or or CC cord-263258-qpzaehg0 32 9 tocilizumab tocilizumab NNP cord-263258-qpzaehg0 32 10 , , , cord-263258-qpzaehg0 32 11 the the DT cord-263258-qpzaehg0 32 12 use use NN cord-263258-qpzaehg0 32 13 of of IN cord-263258-qpzaehg0 32 14 remdesivir remdesivir NNP cord-263258-qpzaehg0 32 15 was be VBD cord-263258-qpzaehg0 32 16 associated associate VBN cord-263258-qpzaehg0 32 17 with with IN cord-263258-qpzaehg0 32 18 an an DT cord-263258-qpzaehg0 32 19 increased increase VBN cord-263258-qpzaehg0 32 20 risk risk NN cord-263258-qpzaehg0 32 21 of of IN cord-263258-qpzaehg0 32 22 reporting report VBG cord-263258-qpzaehg0 32 23 hepatic hepatic JJ cord-263258-qpzaehg0 32 24 disorders disorder NNS cord-263258-qpzaehg0 32 25 ( ( -LRB- cord-263258-qpzaehg0 32 26 ROR ROR NNP cord-263258-qpzaehg0 32 27 1.94 1.94 CD cord-263258-qpzaehg0 32 28 ; ; : cord-263258-qpzaehg0 32 29 95 95 CD cord-263258-qpzaehg0 32 30 % % NN cord-263258-qpzaehg0 32 31 7 7 CD cord-263258-qpzaehg0 32 32 Abbreviations abbreviation NNS cord-263258-qpzaehg0 32 33 : : : cord-263258-qpzaehg0 32 34 CI CI NNP cord-263258-qpzaehg0 32 35 , , , cord-263258-qpzaehg0 32 36 confidence confidence NN cord-263258-qpzaehg0 32 37 interval interval NN cord-263258-qpzaehg0 32 38 ; ; : cord-263258-qpzaehg0 32 39 COVID-19 COVID-19 NNP cord-263258-qpzaehg0 32 40 , , , cord-263258-qpzaehg0 32 41 coronavirus coronavirus NN cord-263258-qpzaehg0 32 42 disease disease NN cord-263258-qpzaehg0 32 43 2019 2019 CD cord-263258-qpzaehg0 32 44 ; ; : cord-263258-qpzaehg0 32 45 ROR ROR NNP cord-263258-qpzaehg0 32 46 , , , cord-263258-qpzaehg0 32 47 reporting report VBG cord-263258-qpzaehg0 32 48 odds odd NNS cord-263258-qpzaehg0 32 49 ratio ratio NN cord-263258-qpzaehg0 32 50 . . . cord-263258-qpzaehg0 33 1 a a DT cord-263258-qpzaehg0 33 2 We -PRON- PRP cord-263258-qpzaehg0 33 3 used use VBD cord-263258-qpzaehg0 33 4 the the DT cord-263258-qpzaehg0 33 5 case case NN cord-263258-qpzaehg0 33 6 non non JJ cord-263258-qpzaehg0 33 7 - - JJ cord-263258-qpzaehg0 33 8 case case JJ cord-263258-qpzaehg0 33 9 method method NN cord-263258-qpzaehg0 33 10 which which WDT cord-263258-qpzaehg0 33 11 is be VBZ cord-263258-qpzaehg0 33 12 similar similar JJ cord-263258-qpzaehg0 33 13 to to IN cord-263258-qpzaehg0 33 14 case case NN cord-263258-qpzaehg0 33 15 - - HYPH cord-263258-qpzaehg0 33 16 control control NN cord-263258-qpzaehg0 33 17 studies study NNS cord-263258-qpzaehg0 33 18 but but CC cord-263258-qpzaehg0 33 19 adapted adapt VBN cord-263258-qpzaehg0 33 20 for for IN cord-263258-qpzaehg0 33 21 pharmacovigilance pharmacovigilance NN cord-263258-qpzaehg0 33 22 studies study NNS cord-263258-qpzaehg0 33 23 . . . cord-263258-qpzaehg0 34 1 We -PRON- PRP cord-263258-qpzaehg0 34 2 used use VBD cord-263258-qpzaehg0 34 3 reporting report VBG cord-263258-qpzaehg0 34 4 odds odd NNS cord-263258-qpzaehg0 34 5 ratios ratio NNS cord-263258-qpzaehg0 34 6 ( ( -LRB- cord-263258-qpzaehg0 34 7 ROR ROR NNP cord-263258-qpzaehg0 34 8 ) ) -RRB- cord-263258-qpzaehg0 34 9 and and CC cord-263258-qpzaehg0 34 10 their -PRON- PRP$ cord-263258-qpzaehg0 34 11 95 95 CD cord-263258-qpzaehg0 34 12 % % NN cord-263258-qpzaehg0 34 13 confidence confidence NN cord-263258-qpzaehg0 34 14 interval interval NN cord-263258-qpzaehg0 34 15 ( ( -LRB- cord-263258-qpzaehg0 34 16 95 95 CD cord-263258-qpzaehg0 34 17 % % NN cord-263258-qpzaehg0 34 18 CI CI NNP cord-263258-qpzaehg0 34 19 ) ) -RRB- cord-263258-qpzaehg0 34 20 to to TO cord-263258-qpzaehg0 34 21 calculate calculate VB cord-263258-qpzaehg0 34 22 disproportionality disproportionality NN cord-263258-qpzaehg0 34 23 . . . cord-263258-qpzaehg0 35 1 ROR ROR NNP cord-263258-qpzaehg0 35 2 is be VBZ cord-263258-qpzaehg0 35 3 a a DT cord-263258-qpzaehg0 35 4 ratio ratio NN cord-263258-qpzaehg0 35 5 similar similar JJ cord-263258-qpzaehg0 35 6 in in IN cord-263258-qpzaehg0 35 7 concept concept NN cord-263258-qpzaehg0 35 8 to to IN cord-263258-qpzaehg0 35 9 the the DT cord-263258-qpzaehg0 35 10 odds odd NNS cord-263258-qpzaehg0 35 11 ratio ratio NN cord-263258-qpzaehg0 35 12 in in IN cord-263258-qpzaehg0 35 13 case case NN cord-263258-qpzaehg0 35 14 - - HYPH cord-263258-qpzaehg0 35 15 control control NN cord-263258-qpzaehg0 35 16 studies study NNS cord-263258-qpzaehg0 35 17 and and CC cord-263258-qpzaehg0 35 18 corresponds correspond VBZ cord-263258-qpzaehg0 35 19 to to IN cord-263258-qpzaehg0 35 20 the the DT cord-263258-qpzaehg0 35 21 exposure exposure NN cord-263258-qpzaehg0 35 22 odds odd NNS cord-263258-qpzaehg0 35 23 among among IN cord-263258-qpzaehg0 35 24 reported report VBN cord-263258-qpzaehg0 35 25 cases case NNS cord-263258-qpzaehg0 35 26 of of IN cord-263258-qpzaehg0 35 27 hepatic hepatic JJ cord-263258-qpzaehg0 35 28 disorders disorder NNS cord-263258-qpzaehg0 35 29 over over IN cord-263258-qpzaehg0 35 30 the the DT cord-263258-qpzaehg0 35 31 exposure exposure NN cord-263258-qpzaehg0 35 32 odds odd NNS cord-263258-qpzaehg0 35 33 among among IN cord-263258-qpzaehg0 35 34 reported report VBN cord-263258-qpzaehg0 35 35 non non JJ cord-263258-qpzaehg0 35 36 - - NN cord-263258-qpzaehg0 35 37 case case NN cord-263258-qpzaehg0 35 38 b b NN cord-263258-qpzaehg0 35 39 Cases case NNS cord-263258-qpzaehg0 36 1 were be VBD cord-263258-qpzaehg0 36 2 individual individual JJ cord-263258-qpzaehg0 36 3 case case NN cord-263258-qpzaehg0 36 4 safety safety NN cord-263258-qpzaehg0 36 5 reports report NNS cord-263258-qpzaehg0 36 6 containing contain VBG cord-263258-qpzaehg0 36 7 any any DT cord-263258-qpzaehg0 36 8 terms term NNS cord-263258-qpzaehg0 36 9 including include VBG cord-263258-qpzaehg0 36 10 the the DT cord-263258-qpzaehg0 36 11 terminology terminology NN cord-263258-qpzaehg0 36 12 " " `` cord-263258-qpzaehg0 36 13 Hepatobiliary Hepatobiliary NNP cord-263258-qpzaehg0 36 14 disorders disorder NNS cord-263258-qpzaehg0 36 15 " " '' cord-263258-qpzaehg0 36 16 in in IN cord-263258-qpzaehg0 36 17 the the DT cord-263258-qpzaehg0 36 18 System System NNP cord-263258-qpzaehg0 36 19 Organ Organ NNP cord-263258-qpzaehg0 36 20 Class Class NNP cord-263258-qpzaehg0 36 21 ( ( -LRB- cord-263258-qpzaehg0 36 22 SOC SOC NNP cord-263258-qpzaehg0 36 23 ) ) -RRB- cord-263258-qpzaehg0 36 24 view view NN cord-263258-qpzaehg0 36 25 found find VBN cord-263258-qpzaehg0 36 26 in in IN cord-263258-qpzaehg0 36 27 MedDRA MedDRA NNP cord-263258-qpzaehg0 36 28 dictionary dictionary NNP cord-263258-qpzaehg0 36 29 https://www.meddra.org/ https://www.meddra.org/ NNP cord-263258-qpzaehg0 36 30 . . . cord-263258-qpzaehg0 37 1 c c LS cord-263258-qpzaehg0 37 2 Non Non NNS cord-263258-qpzaehg0 37 3 - - NNS cord-263258-qpzaehg0 37 4 cases case NNS cord-263258-qpzaehg0 37 5 were be VBD cord-263258-qpzaehg0 37 6 individual individual JJ cord-263258-qpzaehg0 37 7 case case NN cord-263258-qpzaehg0 37 8 safety safety NN cord-263258-qpzaehg0 37 9 reports report NNS cord-263258-qpzaehg0 37 10 containing contain VBG cord-263258-qpzaehg0 37 11 all all DT cord-263258-qpzaehg0 37 12 other other JJ cord-263258-qpzaehg0 37 13 adverse adverse JJ cord-263258-qpzaehg0 37 14 events event NNS cord-263258-qpzaehg0 37 15 reported report VBD cord-263258-qpzaehg0 37 16 linked link VBN cord-263258-qpzaehg0 37 17 with with IN cord-263258-qpzaehg0 37 18 the the DT cord-263258-qpzaehg0 37 19 respective respective JJ cord-263258-qpzaehg0 37 20 drug drug NN cord-263258-qpzaehg0 37 21 . . . cord-263258-qpzaehg0 38 1 d d NNP cord-263258-qpzaehg0 38 2 hydroxychloroquine hydroxychloroquine NNP cord-263258-qpzaehg0 38 3 , , , cord-263258-qpzaehg0 38 4 tocilizumab tocilizumab NNP cord-263258-qpzaehg0 38 5 , , , cord-263258-qpzaehg0 38 6 lopinavir lopinavir NNP cord-263258-qpzaehg0 38 7 / / SYM cord-263258-qpzaehg0 38 8 ritonavir ritonavir NNP cord-263258-qpzaehg0 38 9 prescribed prescribe VBN cord-263258-qpzaehg0 38 10 for for IN cord-263258-qpzaehg0 38 11 COVID-19 COVID-19 NNP cord-263258-qpzaehg0 38 12 patients patient NNS cord-263258-qpzaehg0 38 13 _SP cord-263258-qpzaehg0 39 1 COVID-19 covid-19 LS cord-263258-qpzaehg0 39 2 ) ) -RRB- cord-263258-qpzaehg0 39 3 Update update NN cord-263258-qpzaehg0 39 4 : : : cord-263258-qpzaehg0 40 1 FDA FDA NNP cord-263258-qpzaehg0 40 2 Issues Issues NNPS cord-263258-qpzaehg0 40 3 Emergency Emergency NNP cord-263258-qpzaehg0 40 4 Use Use NNP cord-263258-qpzaehg0 40 5 Authorization Authorization NNP cord-263258-qpzaehg0 40 6 for for IN cord-263258-qpzaehg0 40 7 Potential Potential NNP cord-263258-qpzaehg0 40 8 COVID-19 COVID-19 NNP cord-263258-qpzaehg0 40 9 Treatment Treatment NNP cord-263258-qpzaehg0 40 10 First First NNP cord-263258-qpzaehg0 41 1 COVID-19 covid-19 JJ cord-263258-qpzaehg0 41 2 treatment treatment NN cord-263258-qpzaehg0 41 3 recommended recommend VBN cord-263258-qpzaehg0 41 4 for for IN cord-263258-qpzaehg0 41 5 EU EU NNP cord-263258-qpzaehg0 41 6 authorisation authorisation NN cord-263258-qpzaehg0 41 7 Remdesivir Remdesivir NNP cord-263258-qpzaehg0 41 8 for for IN cord-263258-qpzaehg0 41 9 5 5 CD cord-263258-qpzaehg0 41 10 or or CC cord-263258-qpzaehg0 41 11 10 10 CD cord-263258-qpzaehg0 41 12 Days day NNS cord-263258-qpzaehg0 41 13 in in IN cord-263258-qpzaehg0 41 14 Patients patient NNS cord-263258-qpzaehg0 41 15 with with IN cord-263258-qpzaehg0 41 16 Severe severe JJ cord-263258-qpzaehg0 41 17 Covid-19 covid-19 JJ cord-263258-qpzaehg0 41 18 Compassionate compassionate JJ cord-263258-qpzaehg0 41 19 remdesivir remdesivir JJ cord-263258-qpzaehg0 41 20 treatment treatment NN cord-263258-qpzaehg0 41 21 of of IN cord-263258-qpzaehg0 41 22 severe severe JJ cord-263258-qpzaehg0 41 23 Covid-19 covid-19 JJ cord-263258-qpzaehg0 41 24 pneumonia pneumonia NN cord-263258-qpzaehg0 41 25 in in IN cord-263258-qpzaehg0 41 26 intensive intensive JJ cord-263258-qpzaehg0 41 27 care care NN cord-263258-qpzaehg0 41 28 unit unit NN cord-263258-qpzaehg0 41 29 ( ( -LRB- cord-263258-qpzaehg0 41 30 ICU ICU NNP cord-263258-qpzaehg0 41 31 ) ) -RRB- cord-263258-qpzaehg0 41 32 and and CC cord-263258-qpzaehg0 41 33 Non Non NNP cord-263258-qpzaehg0 41 34 - - JJ cord-263258-qpzaehg0 41 35 ICU icu JJ cord-263258-qpzaehg0 41 36 patients patient NNS cord-263258-qpzaehg0 41 37 : : : cord-263258-qpzaehg0 41 38 Clinical clinical JJ cord-263258-qpzaehg0 41 39 outcome outcome NN cord-263258-qpzaehg0 41 40 and and CC cord-263258-qpzaehg0 41 41 differences difference NNS cord-263258-qpzaehg0 41 42 in in IN cord-263258-qpzaehg0 41 43 post post JJ cord-263258-qpzaehg0 41 44 - - JJ cord-263258-qpzaehg0 41 45 treatment treatment JJ cord-263258-qpzaehg0 41 46 hospitalisation hospitalisation NN cord-263258-qpzaehg0 41 47 status status NN cord-263258-qpzaehg0 41 48 Compassionate compassionate JJ cord-263258-qpzaehg0 41 49 Use Use NNP cord-263258-qpzaehg0 41 50 of of IN cord-263258-qpzaehg0 41 51 Remdesivir Remdesivir NNP cord-263258-qpzaehg0 41 52 for for IN cord-263258-qpzaehg0 41 53 Patients patient NNS cord-263258-qpzaehg0 41 54 with with IN cord-263258-qpzaehg0 41 55 Severe Severe NNP cord-263258-qpzaehg0 41 56 Covid-19 Covid-19 NNP cord-263258-qpzaehg0 41 57 Remdesivir Remdesivir NNP cord-263258-qpzaehg0 41 58 in in IN cord-263258-qpzaehg0 41 59 adults adult NNS cord-263258-qpzaehg0 41 60 with with IN cord-263258-qpzaehg0 41 61 severe severe JJ cord-263258-qpzaehg0 41 62 COVID-19 covid-19 NN cord-263258-qpzaehg0 41 63 : : : cord-263258-qpzaehg0 41 64 a a DT cord-263258-qpzaehg0 41 65 randomised randomised JJ cord-263258-qpzaehg0 41 66 , , , cord-263258-qpzaehg0 41 67 double double JJ cord-263258-qpzaehg0 41 68 - - HYPH cord-263258-qpzaehg0 41 69 blind blind JJ cord-263258-qpzaehg0 41 70 , , , cord-263258-qpzaehg0 41 71 placebo placebo NN cord-263258-qpzaehg0 41 72 - - HYPH cord-263258-qpzaehg0 41 73 controlled control VBN cord-263258-qpzaehg0 41 74 , , , cord-263258-qpzaehg0 41 75 multicentre multicentre NNP cord-263258-qpzaehg0 41 76 trial trial NN cord-263258-qpzaehg0 41 77 the the DT cord-263258-qpzaehg0 41 78 WHO WHO NNP cord-263258-qpzaehg0 41 79 Global Global NNP cord-263258-qpzaehg0 41 80 ICSR ICSR NNP cord-263258-qpzaehg0 41 81 Database Database NNP cord-263258-qpzaehg0 41 82 System system NN cord-263258-qpzaehg0 41 83 : : : cord-263258-qpzaehg0 41 84 Basic basic JJ cord-263258-qpzaehg0 41 85 Facts fact NNS cord-263258-qpzaehg0 41 86 Case case NN cord-263258-qpzaehg0 41 87 - - HYPH cord-263258-qpzaehg0 41 88 non non JJ cord-263258-qpzaehg0 41 89 - - JJ cord-263258-qpzaehg0 41 90 case case JJ cord-263258-qpzaehg0 41 91 studies study NNS cord-263258-qpzaehg0 41 92 : : : cord-263258-qpzaehg0 41 93 Principle principle NN cord-263258-qpzaehg0 41 94 , , , cord-263258-qpzaehg0 41 95 methods method NNS cord-263258-qpzaehg0 41 96 , , , cord-263258-qpzaehg0 41 97 bias bias NN cord-263258-qpzaehg0 41 98 and and CC cord-263258-qpzaehg0 41 99 interpretation interpretation NN cord-263258-qpzaehg0 42 1 The the DT cord-263258-qpzaehg0 42 2 authors author NNS cord-263258-qpzaehg0 42 3 acknowledge acknowledge VBP cord-263258-qpzaehg0 42 4 the the DT cord-263258-qpzaehg0 42 5 Uppsala Uppsala NNP cord-263258-qpzaehg0 42 6 Monitoring Monitoring NNP cord-263258-qpzaehg0 42 7 Centre Centre NNP cord-263258-qpzaehg0 42 8 ( ( -LRB- cord-263258-qpzaehg0 42 9 UMC UMC NNP cord-263258-qpzaehg0 42 10 ) ) -RRB- cord-263258-qpzaehg0 42 11 who who WP cord-263258-qpzaehg0 42 12 provided provide VBD cord-263258-qpzaehg0 42 13 and and CC cord-263258-qpzaehg0 42 14 gave give VBD cord-263258-qpzaehg0 42 15 permission permission NN cord-263258-qpzaehg0 42 16 to to TO cord-263258-qpzaehg0 42 17 use use VB cord-263258-qpzaehg0 42 18 the the DT cord-263258-qpzaehg0 42 19 data datum NNS cord-263258-qpzaehg0 42 20 analyzed analyze VBN cord-263258-qpzaehg0 42 21 in in IN cord-263258-qpzaehg0 42 22 the the DT cord-263258-qpzaehg0 42 23 present present JJ cord-263258-qpzaehg0 42 24 study study NN cord-263258-qpzaehg0 42 25 . . . cord-263258-qpzaehg0 43 1 Access access NN cord-263258-qpzaehg0 43 2 to to IN cord-263258-qpzaehg0 43 3 the the DT cord-263258-qpzaehg0 43 4 World World NNP cord-263258-qpzaehg0 43 5 Health Health NNP cord-263258-qpzaehg0 43 6 Organization Organization NNP cord-263258-qpzaehg0 43 7 global global JJ cord-263258-qpzaehg0 43 8 individual individual JJ cord-263258-qpzaehg0 43 9 case case NN cord-263258-qpzaehg0 43 10 safety safety NN cord-263258-qpzaehg0 43 11 report report NN cord-263258-qpzaehg0 43 12 database database NN cord-263258-qpzaehg0 43 13 , , , cord-263258-qpzaehg0 43 14 VigiBase VigiBase NNP cord-263258-qpzaehg0 43 15 ® ® NNP cord-263258-qpzaehg0 43 16 , , , cord-263258-qpzaehg0 43 17 is be VBZ cord-263258-qpzaehg0 43 18 available available JJ cord-263258-qpzaehg0 43 19 without without IN