id sid tid token lemma pos cord-258230-s4ty52kb 1 1 key key JJ cord-258230-s4ty52kb 1 2 : : : cord-258230-s4ty52kb 1 3 cord-258230-s4ty52 cord-258230-s4ty52 JJ cord-258230-s4ty52kb 1 4 kb kb NNP cord-258230-s4ty52kb 1 5 authors author NNS cord-258230-s4ty52kb 1 6 : : : cord-258230-s4ty52kb 1 7 Grover Grover NNP cord-258230-s4ty52kb 1 8 , , , cord-258230-s4ty52kb 1 9 Abhinav Abhinav NNP cord-258230-s4ty52kb 1 10 ; ; : cord-258230-s4ty52kb 1 11 Oberoi Oberoi NNP cord-258230-s4ty52kb 1 12 , , , cord-258230-s4ty52kb 1 13 Mansi Mansi NNP cord-258230-s4ty52kb 1 14 title title NN cord-258230-s4ty52kb 1 15 : : : cord-258230-s4ty52kb 2 1 A a DT cord-258230-s4ty52kb 2 2 systematic systematic JJ cord-258230-s4ty52kb 2 3 review review NN cord-258230-s4ty52kb 2 4 and and CC cord-258230-s4ty52kb 2 5 meta meta NNP cord-258230-s4ty52kb 2 6 - - HYPH cord-258230-s4ty52kb 2 7 analysis analysis NN cord-258230-s4ty52kb 2 8 to to TO cord-258230-s4ty52kb 2 9 evaluate evaluate VB cord-258230-s4ty52kb 2 10 the the DT cord-258230-s4ty52kb 2 11 clinical clinical JJ cord-258230-s4ty52kb 2 12 outcomes outcome NNS cord-258230-s4ty52kb 2 13 in in IN cord-258230-s4ty52kb 2 14 COVID-19 covid-19 JJ cord-258230-s4ty52kb 2 15 patients patient NNS cord-258230-s4ty52kb 2 16 on on IN cord-258230-s4ty52kb 2 17 angiotensin angiotensin NN cord-258230-s4ty52kb 2 18 - - HYPH cord-258230-s4ty52kb 2 19 converting convert VBG cord-258230-s4ty52kb 2 20 enzyme enzyme NN cord-258230-s4ty52kb 2 21 inhibitors inhibitor NNS cord-258230-s4ty52kb 2 22 or or CC cord-258230-s4ty52kb 2 23 angiotensin angiotensin NN cord-258230-s4ty52kb 2 24 receptor receptor NN cord-258230-s4ty52kb 2 25 blockers blocker NNS cord-258230-s4ty52kb 2 26 date date NN cord-258230-s4ty52kb 2 27 : : : cord-258230-s4ty52kb 2 28 2020 2020 CD cord-258230-s4ty52kb 2 29 - - HYPH cord-258230-s4ty52kb 2 30 06 06 CD cord-258230-s4ty52kb 2 31 - - SYM cord-258230-s4ty52kb 2 32 15 15 CD cord-258230-s4ty52kb 2 33 journal journal NN cord-258230-s4ty52kb 2 34 : : : cord-258230-s4ty52kb 3 1 Eur Eur NNP cord-258230-s4ty52kb 3 2 Heart Heart NNP cord-258230-s4ty52kb 3 3 J J NNP cord-258230-s4ty52kb 3 4 Cardiovasc Cardiovasc NNP cord-258230-s4ty52kb 3 5 Pharmacother Pharmacother NNP cord-258230-s4ty52kb 3 6 DOI DOI NNP cord-258230-s4ty52kb 3 7 : : : cord-258230-s4ty52kb 4 1 10.1093 10.1093 CD cord-258230-s4ty52kb 4 2 / / SYM cord-258230-s4ty52kb 4 3 ehjcvp ehjcvp NNP cord-258230-s4ty52kb 4 4 / / SYM cord-258230-s4ty52kb 4 5 pvaa064 pvaa064 NNP cord-258230-s4ty52kb 4 6 sha sha NNP cord-258230-s4ty52kb 4 7 : : : cord-258230-s4ty52kb 4 8 596cabaca1105d86b0f878ce55763541f10ec469 596cabaca1105d86b0f878ce55763541f10ec469 CD cord-258230-s4ty52kb 4 9 doc_id doc_id CD cord-258230-s4ty52kb 4 10 : : : cord-258230-s4ty52kb 4 11 258230 258230 CD cord-258230-s4ty52kb 4 12 cord_uid cord_uid NNS cord-258230-s4ty52kb 4 13 : : : cord-258230-s4ty52kb 5 1 s4ty52 s4ty52 NNP cord-258230-s4ty52kb 6 1 kb kb NNP cord-258230-s4ty52kb 6 2 INTRODUCTION INTRODUCTION NNP cord-258230-s4ty52kb 6 3 : : : cord-258230-s4ty52kb 7 1 Angiotensin angiotensin NN cord-258230-s4ty52kb 7 2 - - HYPH cord-258230-s4ty52kb 7 3 converting convert VBG cord-258230-s4ty52kb 7 4 enzyme enzyme NN cord-258230-s4ty52kb 7 5 inhibitors inhibitor NNS cord-258230-s4ty52kb 7 6 ( ( -LRB- cord-258230-s4ty52kb 7 7 ACEIs acei NNS cord-258230-s4ty52kb 7 8 ) ) -RRB- cord-258230-s4ty52kb 7 9 and and CC cord-258230-s4ty52kb 7 10 angiotensin angiotensin NN cord-258230-s4ty52kb 7 11 receptor receptor NN cord-258230-s4ty52kb 7 12 blockers blocker NNS cord-258230-s4ty52kb 7 13 ( ( -LRB- cord-258230-s4ty52kb 7 14 ARBs arb NNS cord-258230-s4ty52kb 7 15 ) ) -RRB- cord-258230-s4ty52kb 7 16 share share VBP cord-258230-s4ty52kb 7 17 their -PRON- PRP$ cord-258230-s4ty52kb 7 18 target target NN cord-258230-s4ty52kb 7 19 receptor receptor NN cord-258230-s4ty52kb 7 20 site site NN cord-258230-s4ty52kb 7 21 with with IN cord-258230-s4ty52kb 7 22 the the DT cord-258230-s4ty52kb 7 23 SARS SARS NNP cord-258230-s4ty52kb 7 24 - - HYPH cord-258230-s4ty52kb 7 25 CoV-2 CoV-2 NNP cord-258230-s4ty52kb 7 26 virus virus NN cord-258230-s4ty52kb 7 27 , , , cord-258230-s4ty52kb 7 28 that that WDT cord-258230-s4ty52kb 7 29 may may MD cord-258230-s4ty52kb 7 30 cause cause VB cord-258230-s4ty52kb 7 31 ACE2 ACE2 NNP cord-258230-s4ty52kb 7 32 receptor receptor NN cord-258230-s4ty52kb 7 33 up up IN cord-258230-s4ty52kb 7 34 - - HYPH cord-258230-s4ty52kb 7 35 regulation regulation NN cord-258230-s4ty52kb 7 36 which which WDT cord-258230-s4ty52kb 7 37 raised raise VBD cord-258230-s4ty52kb 7 38 concerns concern NNS cord-258230-s4ty52kb 7 39 regarding regard VBG cord-258230-s4ty52kb 7 40 ACEI ACEI NNP cord-258230-s4ty52kb 7 41 and and CC cord-258230-s4ty52kb 7 42 ARB ARB NNP cord-258230-s4ty52kb 7 43 use use NN cord-258230-s4ty52kb 7 44 in in IN cord-258230-s4ty52kb 7 45 COVID-19 covid-19 JJ cord-258230-s4ty52kb 7 46 patients patient NNS cord-258230-s4ty52kb 7 47 . . . cord-258230-s4ty52kb 8 1 However however RB cord-258230-s4ty52kb 8 2 , , , cord-258230-s4ty52kb 8 3 many many JJ cord-258230-s4ty52kb 8 4 medical medical JJ cord-258230-s4ty52kb 8 5 professional professional JJ cord-258230-s4ty52kb 8 6 societies society NNS cord-258230-s4ty52kb 8 7 recommended recommend VBD cord-258230-s4ty52kb 8 8 their -PRON- PRP$ cord-258230-s4ty52kb 8 9 continued continue VBN cord-258230-s4ty52kb 8 10 use use NN cord-258230-s4ty52kb 8 11 given give VBN cord-258230-s4ty52kb 8 12 the the DT cord-258230-s4ty52kb 8 13 paucity paucity NN cord-258230-s4ty52kb 8 14 of of IN cord-258230-s4ty52kb 8 15 clinical clinical JJ cord-258230-s4ty52kb 8 16 evidence evidence NN cord-258230-s4ty52kb 8 17 , , , cord-258230-s4ty52kb 8 18 but but CC cord-258230-s4ty52kb 8 19 there there EX cord-258230-s4ty52kb 8 20 is be VBZ cord-258230-s4ty52kb 8 21 a a DT cord-258230-s4ty52kb 8 22 need need NN cord-258230-s4ty52kb 8 23 for for IN cord-258230-s4ty52kb 8 24 an an DT cord-258230-s4ty52kb 8 25 updated update VBN cord-258230-s4ty52kb 8 26 systematic systematic JJ cord-258230-s4ty52kb 8 27 review review NN cord-258230-s4ty52kb 8 28 and and CC cord-258230-s4ty52kb 8 29 meta meta NNP cord-258230-s4ty52kb 8 30 - - HYPH cord-258230-s4ty52kb 8 31 analysis analysis NN cord-258230-s4ty52kb 8 32 of of IN cord-258230-s4ty52kb 8 33 the the DT cord-258230-s4ty52kb 8 34 latest late JJS cord-258230-s4ty52kb 8 35 clinical clinical JJ cord-258230-s4ty52kb 8 36 studies study NNS cord-258230-s4ty52kb 8 37 . . . cord-258230-s4ty52kb 9 1 METHODS method NNS cord-258230-s4ty52kb 9 2 AND and CC cord-258230-s4ty52kb 9 3 RESULTS result NNS cord-258230-s4ty52kb 9 4 : : : cord-258230-s4ty52kb 10 1 A a DT cord-258230-s4ty52kb 10 2 search search NN cord-258230-s4ty52kb 10 3 was be VBD cord-258230-s4ty52kb 10 4 conducted conduct VBN cord-258230-s4ty52kb 10 5 on on IN cord-258230-s4ty52kb 10 6 PubMed PubMed NNP cord-258230-s4ty52kb 10 7 , , , cord-258230-s4ty52kb 10 8 Google Google NNP cord-258230-s4ty52kb 10 9 Scholar Scholar NNP cord-258230-s4ty52kb 10 10 , , , cord-258230-s4ty52kb 10 11 EMBASE EMBASE NNP cord-258230-s4ty52kb 10 12 , , , cord-258230-s4ty52kb 10 13 and and CC cord-258230-s4ty52kb 10 14 various various JJ cord-258230-s4ty52kb 10 15 preprint preprint NN cord-258230-s4ty52kb 10 16 servers server NNS cord-258230-s4ty52kb 10 17 for for IN cord-258230-s4ty52kb 10 18 studies study NNS cord-258230-s4ty52kb 10 19 comparing compare VBG cord-258230-s4ty52kb 10 20 clinical clinical JJ cord-258230-s4ty52kb 10 21 outcomes outcome NNS cord-258230-s4ty52kb 10 22 and and CC cord-258230-s4ty52kb 10 23 mortality mortality NN cord-258230-s4ty52kb 10 24 in in IN cord-258230-s4ty52kb 10 25 COVID-19 covid-19 JJ cord-258230-s4ty52kb 10 26 patients patient NNS cord-258230-s4ty52kb 10 27 on on IN cord-258230-s4ty52kb 10 28 ACEIs acei NNS cord-258230-s4ty52kb 10 29 and/or and/or CC cord-258230-s4ty52kb 10 30 ARBs arb NNS cord-258230-s4ty52kb 10 31 , , , cord-258230-s4ty52kb 10 32 and and CC cord-258230-s4ty52kb 10 33 a a DT cord-258230-s4ty52kb 10 34 meta meta JJ cord-258230-s4ty52kb 10 35 - - HYPH cord-258230-s4ty52kb 10 36 analysis analysis NN cord-258230-s4ty52kb 10 37 was be VBD cord-258230-s4ty52kb 10 38 performed perform VBN cord-258230-s4ty52kb 10 39 . . . cord-258230-s4ty52kb 11 1 A a DT cord-258230-s4ty52kb 11 2 total total NN cord-258230-s4ty52kb 11 3 of of IN cord-258230-s4ty52kb 11 4 16 16 CD cord-258230-s4ty52kb 11 5 studies study NNS cord-258230-s4ty52kb 11 6 were be VBD cord-258230-s4ty52kb 11 7 included include VBN cord-258230-s4ty52kb 11 8 for for IN cord-258230-s4ty52kb 11 9 the the DT cord-258230-s4ty52kb 11 10 review review NN cord-258230-s4ty52kb 11 11 and and CC cord-258230-s4ty52kb 11 12 meta meta NNP cord-258230-s4ty52kb 11 13 - - HYPH cord-258230-s4ty52kb 11 14 analysis analysis NN cord-258230-s4ty52kb 11 15 . . . cord-258230-s4ty52kb 12 1 There there EX cord-258230-s4ty52kb 12 2 were be VBD cord-258230-s4ty52kb 12 3 conflicting conflict VBG cord-258230-s4ty52kb 12 4 findings finding NNS cord-258230-s4ty52kb 12 5 reported report VBN cord-258230-s4ty52kb 12 6 in in IN cord-258230-s4ty52kb 12 7 the the DT cord-258230-s4ty52kb 12 8 rates rate NNS cord-258230-s4ty52kb 12 9 of of IN cord-258230-s4ty52kb 12 10 severity severity NN cord-258230-s4ty52kb 12 11 and and CC cord-258230-s4ty52kb 12 12 mortality mortality NN cord-258230-s4ty52kb 12 13 in in IN cord-258230-s4ty52kb 12 14 several several JJ cord-258230-s4ty52kb 12 15 studies study NNS cord-258230-s4ty52kb 12 16 . . . cord-258230-s4ty52kb 13 1 In in IN cord-258230-s4ty52kb 13 2 a a DT cord-258230-s4ty52kb 13 3 pooled pool VBN cord-258230-s4ty52kb 13 4 analysis analysis NN cord-258230-s4ty52kb 13 5 of of IN cord-258230-s4ty52kb 13 6 four four CD cord-258230-s4ty52kb 13 7 studies study NNS cord-258230-s4ty52kb 13 8 , , , cord-258230-s4ty52kb 13 9 there there EX cord-258230-s4ty52kb 13 10 was be VBD cord-258230-s4ty52kb 13 11 a a DT cord-258230-s4ty52kb 13 12 statistically statistically RB cord-258230-s4ty52kb 13 13 non non JJ cord-258230-s4ty52kb 13 14 - - JJ cord-258230-s4ty52kb 13 15 significant significant JJ cord-258230-s4ty52kb 13 16 association association NN cord-258230-s4ty52kb 13 17 of of IN cord-258230-s4ty52kb 13 18 ACEI ACEI NNP cord-258230-s4ty52kb 13 19 / / SYM cord-258230-s4ty52kb 13 20 ARB ARB NNP cord-258230-s4ty52kb 13 21 use use NN cord-258230-s4ty52kb 13 22 with with IN cord-258230-s4ty52kb 13 23 lower low JJR cord-258230-s4ty52kb 13 24 odds odd NNS cord-258230-s4ty52kb 13 25 of of IN cord-258230-s4ty52kb 13 26 developing develop VBG cord-258230-s4ty52kb 13 27 severe severe JJ cord-258230-s4ty52kb 13 28 disease disease NN cord-258230-s4ty52kb 13 29 vs. vs. FW cord-258230-s4ty52kb 13 30 non non NNS cord-258230-s4ty52kb 13 31 - - NNS cord-258230-s4ty52kb 13 32 users user NNS cord-258230-s4ty52kb 13 33 [ [ -LRB- cord-258230-s4ty52kb 13 34 odds odd NNS cord-258230-s4ty52kb 13 35 ratio ratio NN cord-258230-s4ty52kb 13 36 ( ( -LRB- cord-258230-s4ty52kb 13 37 OR OR NNP cord-258230-s4ty52kb 13 38 ) ) -RRB- cord-258230-s4ty52kb 13 39 = = SYM cord-258230-s4ty52kb 13 40 0.81 0.81 CD cord-258230-s4ty52kb 13 41 , , , cord-258230-s4ty52kb 13 42 95 95 CD cord-258230-s4ty52kb 13 43 % % NN cord-258230-s4ty52kb 13 44 confidence confidence NN cord-258230-s4ty52kb 13 45 interval interval NN cord-258230-s4ty52kb 13 46 ( ( -LRB- cord-258230-s4ty52kb 13 47 CI ci NN cord-258230-s4ty52kb 13 48 ) ) -RRB- cord-258230-s4ty52kb 13 49 : : : cord-258230-s4ty52kb 13 50 0.41–1.58 0.41–1.58 NNP cord-258230-s4ty52kb 13 51 , , , cord-258230-s4ty52kb 13 52 I(2)=50.52 I(2)=50.52 NNP cord-258230-s4ty52kb 13 53 , , , cord-258230-s4ty52kb 13 54 P p NN cord-258230-s4ty52kb 13 55 - - HYPH cord-258230-s4ty52kb 13 56 value value NN cord-258230-s4ty52kb 13 57 = = SYM cord-258230-s4ty52kb 13 58 0.53 0.53 CD cord-258230-s4ty52kb 13 59 ) ) -RRB- cord-258230-s4ty52kb 13 60 . . . cord-258230-s4ty52kb 14 1 In in IN cord-258230-s4ty52kb 14 2 a a DT cord-258230-s4ty52kb 14 3 pooled pool VBN cord-258230-s4ty52kb 14 4 analysis analysis NN cord-258230-s4ty52kb 14 5 of of IN cord-258230-s4ty52kb 14 6 six six CD cord-258230-s4ty52kb 14 7 studies study NNS cord-258230-s4ty52kb 14 8 , , , cord-258230-s4ty52kb 14 9 there there EX cord-258230-s4ty52kb 14 10 was be VBD cord-258230-s4ty52kb 14 11 a a DT cord-258230-s4ty52kb 14 12 statistically statistically RB cord-258230-s4ty52kb 14 13 non non JJ cord-258230-s4ty52kb 14 14 - - JJ cord-258230-s4ty52kb 14 15 significant significant JJ cord-258230-s4ty52kb 14 16 association association NN cord-258230-s4ty52kb 14 17 of of IN cord-258230-s4ty52kb 14 18 ACEI ACEI NNP cord-258230-s4ty52kb 14 19 / / SYM cord-258230-s4ty52kb 14 20 ARB ARB NNP cord-258230-s4ty52kb 14 21 use use NN cord-258230-s4ty52kb 14 22 with with IN cord-258230-s4ty52kb 14 23 lower low JJR cord-258230-s4ty52kb 14 24 odds odd NNS cord-258230-s4ty52kb 14 25 of of IN cord-258230-s4ty52kb 14 26 mortality mortality NN cord-258230-s4ty52kb 14 27 as as IN cord-258230-s4ty52kb 14 28 compared compare VBN cord-258230-s4ty52kb 14 29 with with IN cord-258230-s4ty52kb 14 30 non non NNS cord-258230-s4ty52kb 14 31 - - NNS cord-258230-s4ty52kb 14 32 users user NNS cord-258230-s4ty52kb 14 33 ( ( -LRB- cord-258230-s4ty52kb 14 34 OR or CC cord-258230-s4ty52kb 14 35 = = SYM cord-258230-s4ty52kb 14 36 0.86 0.86 CD cord-258230-s4ty52kb 14 37 , , , cord-258230-s4ty52kb 14 38 95 95 CD cord-258230-s4ty52kb 14 39 % % NN cord-258230-s4ty52kb 14 40 CI ci NN cord-258230-s4ty52kb 14 41 = = SYM cord-258230-s4ty52kb 14 42 0.53–1.41 0.53–1.41 NNP cord-258230-s4ty52kb 14 43 , , , cord-258230-s4ty52kb 14 44 I(2 I(2 NNP cord-258230-s4ty52kb 14 45 ) ) -RRB- cord-258230-s4ty52kb 14 46 = = NFP cord-258230-s4ty52kb 15 1 79.12 79.12 CD cord-258230-s4ty52kb 15 2 , , , cord-258230-s4ty52kb 15 3 P p NN cord-258230-s4ty52kb 15 4 - - HYPH cord-258230-s4ty52kb 15 5 value value NN cord-258230-s4ty52kb 15 6 = = SYM cord-258230-s4ty52kb 15 7 0.55 0.55 CD cord-258230-s4ty52kb 15 8 ) ) -RRB- cord-258230-s4ty52kb 15 9 . . . cord-258230-s4ty52kb 16 1 CONCLUSION conclusion NN cord-258230-s4ty52kb 16 2 : : : cord-258230-s4ty52kb 17 1 It -PRON- PRP cord-258230-s4ty52kb 17 2 is be VBZ cord-258230-s4ty52kb 17 3 concluded conclude VBN cord-258230-s4ty52kb 17 4 that that IN cord-258230-s4ty52kb 17 5 ACEIs acei NNS cord-258230-s4ty52kb 17 6 and and CC cord-258230-s4ty52kb 17 7 ARBs arb NNS cord-258230-s4ty52kb 17 8 should should MD cord-258230-s4ty52kb 17 9 be be VB cord-258230-s4ty52kb 17 10 continued continue VBN cord-258230-s4ty52kb 17 11 in in IN cord-258230-s4ty52kb 17 12 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 17 13 patients patient NNS cord-258230-s4ty52kb 17 14 , , , cord-258230-s4ty52kb 17 15 reinforcing reinforce VBG cord-258230-s4ty52kb 17 16 the the DT cord-258230-s4ty52kb 17 17 recommendations recommendation NNS cord-258230-s4ty52kb 17 18 made make VBN cord-258230-s4ty52kb 17 19 by by IN cord-258230-s4ty52kb 17 20 several several JJ cord-258230-s4ty52kb 17 21 medical medical JJ cord-258230-s4ty52kb 17 22 societies society NNS cord-258230-s4ty52kb 17 23 . . . cord-258230-s4ty52kb 18 1 Additionally additionally RB cord-258230-s4ty52kb 18 2 , , , cord-258230-s4ty52kb 18 3 the the DT cord-258230-s4ty52kb 18 4 individual individual JJ cord-258230-s4ty52kb 18 5 patient patient NN cord-258230-s4ty52kb 18 6 factors factor NNS cord-258230-s4ty52kb 18 7 such such JJ cord-258230-s4ty52kb 18 8 as as IN cord-258230-s4ty52kb 18 9 ACE2 ACE2 NNP cord-258230-s4ty52kb 18 10 polymorphisms polymorphism NNS cord-258230-s4ty52kb 18 11 which which WDT cord-258230-s4ty52kb 18 12 might may MD cord-258230-s4ty52kb 18 13 confer confer VB cord-258230-s4ty52kb 18 14 higher high JJR cord-258230-s4ty52kb 18 15 risk risk NN cord-258230-s4ty52kb 18 16 of of IN cord-258230-s4ty52kb 18 17 adverse adverse JJ cord-258230-s4ty52kb 18 18 outcomes outcome NNS cord-258230-s4ty52kb 18 19 need need VBP cord-258230-s4ty52kb 18 20 to to TO cord-258230-s4ty52kb 18 21 be be VB cord-258230-s4ty52kb 18 22 evaluated evaluate VBN cord-258230-s4ty52kb 18 23 further further RB cord-258230-s4ty52kb 18 24 . . . cord-258230-s4ty52kb 19 1 Severe severe JJ cord-258230-s4ty52kb 19 2 acute acute JJ cord-258230-s4ty52kb 19 3 respiratory respiratory JJ cord-258230-s4ty52kb 19 4 syndrome syndrome NN cord-258230-s4ty52kb 19 5 coronavirus coronavirus NN cord-258230-s4ty52kb 19 6 2 2 CD cord-258230-s4ty52kb 20 1 ( ( -LRB- cord-258230-s4ty52kb 20 2 SARS SARS NNP cord-258230-s4ty52kb 20 3 - - HYPH cord-258230-s4ty52kb 20 4 COV2 COV2 NNP cord-258230-s4ty52kb 20 5 ) ) -RRB- cord-258230-s4ty52kb 20 6 causes cause VBZ cord-258230-s4ty52kb 20 7 coronavirus coronavirus NN cord-258230-s4ty52kb 20 8 disease disease NN cord-258230-s4ty52kb 20 9 ( ( -LRB- cord-258230-s4ty52kb 20 10 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 20 11 ) ) -RRB- cord-258230-s4ty52kb 20 12 , , , cord-258230-s4ty52kb 20 13 a a DT cord-258230-s4ty52kb 20 14 potentially potentially RB cord-258230-s4ty52kb 20 15 fatal fatal JJ cord-258230-s4ty52kb 20 16 disease disease NN cord-258230-s4ty52kb 20 17 that that WDT cord-258230-s4ty52kb 20 18 is be VBZ cord-258230-s4ty52kb 20 19 of of IN cord-258230-s4ty52kb 20 20 immense immense JJ cord-258230-s4ty52kb 20 21 global global JJ cord-258230-s4ty52kb 20 22 public public JJ cord-258230-s4ty52kb 20 23 health health NN cord-258230-s4ty52kb 20 24 concern concern NN cord-258230-s4ty52kb 20 25 . . . cord-258230-s4ty52kb 21 1 The the DT cord-258230-s4ty52kb 21 2 initial initial JJ cord-258230-s4ty52kb 21 3 cases case NNS cord-258230-s4ty52kb 21 4 were be VBD cord-258230-s4ty52kb 21 5 reported report VBN cord-258230-s4ty52kb 21 6 in in IN cord-258230-s4ty52kb 21 7 December December NNP cord-258230-s4ty52kb 21 8 2019 2019 CD cord-258230-s4ty52kb 21 9 in in IN cord-258230-s4ty52kb 21 10 Wuhan Wuhan NNP cord-258230-s4ty52kb 21 11 , , , cord-258230-s4ty52kb 21 12 China China NNP cord-258230-s4ty52kb 21 13 . . . cord-258230-s4ty52kb 22 1 1 1 LS cord-258230-s4ty52kb 23 1 Since since IN cord-258230-s4ty52kb 23 2 then then RB cord-258230-s4ty52kb 23 3 , , , cord-258230-s4ty52kb 23 4 there there EX cord-258230-s4ty52kb 23 5 have have VBP cord-258230-s4ty52kb 23 6 been be VBN cord-258230-s4ty52kb 23 7 3 3 CD cord-258230-s4ty52kb 23 8 041 041 CD cord-258230-s4ty52kb 23 9 764 764 CD cord-258230-s4ty52kb 23 10 confirmed confirm VBD cord-258230-s4ty52kb 24 1 COVID-19 covid-19 JJ cord-258230-s4ty52kb 24 2 patients patient NNS cord-258230-s4ty52kb 24 3 in in IN cord-258230-s4ty52kb 24 4 the the DT cord-258230-s4ty52kb 24 5 world world NN cord-258230-s4ty52kb 24 6 as as IN cord-258230-s4ty52kb 24 7 of of IN cord-258230-s4ty52kb 24 8 27 27 CD cord-258230-s4ty52kb 24 9 April April NNP cord-258230-s4ty52kb 24 10 2020 2020 CD cord-258230-s4ty52kb 24 11 , , , cord-258230-s4ty52kb 24 12 with with IN cord-258230-s4ty52kb 24 13 a a DT cord-258230-s4ty52kb 24 14 total total NN cord-258230-s4ty52kb 24 15 of of IN cord-258230-s4ty52kb 24 16 211 211 CD cord-258230-s4ty52kb 24 17 167 167 CD cord-258230-s4ty52kb 24 18 deaths death NNS cord-258230-s4ty52kb 24 19 . . . cord-258230-s4ty52kb 25 1 The the DT cord-258230-s4ty52kb 25 2 USA USA NNP cord-258230-s4ty52kb 25 3 has have VBZ cord-258230-s4ty52kb 25 4 the the DT cord-258230-s4ty52kb 25 5 greatest great JJS cord-258230-s4ty52kb 25 6 number number NN cord-258230-s4ty52kb 25 7 ( ( -LRB- cord-258230-s4ty52kb 25 8 988 988 CD cord-258230-s4ty52kb 25 9 189 189 CD cord-258230-s4ty52kb 25 10 ) ) -RRB- cord-258230-s4ty52kb 25 11 of of IN cord-258230-s4ty52kb 25 12 confirmed confirm VBN cord-258230-s4ty52kb 25 13 cases case NNS cord-258230-s4ty52kb 25 14 , , , cord-258230-s4ty52kb 25 15 with with IN cord-258230-s4ty52kb 25 16 a a DT cord-258230-s4ty52kb 25 17 total total NN cord-258230-s4ty52kb 25 18 of of IN cord-258230-s4ty52kb 25 19 56 56 CD cord-258230-s4ty52kb 25 20 259 259 CD cord-258230-s4ty52kb 25 21 deaths death NNS cord-258230-s4ty52kb 25 22 . . . cord-258230-s4ty52kb 26 1 Most Most JJS cord-258230-s4ty52kb 26 2 cases case NNS cord-258230-s4ty52kb 26 3 were be VBD cord-258230-s4ty52kb 26 4 diagnosed diagnose VBN cord-258230-s4ty52kb 26 5 in in IN cord-258230-s4ty52kb 26 6 New New NNP cord-258230-s4ty52kb 26 7 York York NNP cord-258230-s4ty52kb 26 8 ( ( -LRB- cord-258230-s4ty52kb 26 9 291 291 CD cord-258230-s4ty52kb 26 10 996 996 CD cord-258230-s4ty52kb 26 11 ) ) -RRB- cord-258230-s4ty52kb 26 12 , , , cord-258230-s4ty52kb 26 13 with with IN cord-258230-s4ty52kb 26 14 a a DT cord-258230-s4ty52kb 26 15 total total NN cord-258230-s4ty52kb 26 16 of of IN cord-258230-s4ty52kb 26 17 22 22 CD cord-258230-s4ty52kb 26 18 668 668 CD cord-258230-s4ty52kb 26 19 deaths death NNS cord-258230-s4ty52kb 26 20 . . . cord-258230-s4ty52kb 27 1 2 2 LS cord-258230-s4ty52kb 28 1 Several several JJ cord-258230-s4ty52kb 28 2 studies study NNS cord-258230-s4ty52kb 28 3 , , , cord-258230-s4ty52kb 28 4 including include VBG cord-258230-s4ty52kb 28 5 a a DT cord-258230-s4ty52kb 28 6 recent recent JJ cord-258230-s4ty52kb 28 7 meta meta JJ cord-258230-s4ty52kb 28 8 - - HYPH cord-258230-s4ty52kb 28 9 analysis analysis NN cord-258230-s4ty52kb 28 10 , , , cord-258230-s4ty52kb 28 11 have have VBP cord-258230-s4ty52kb 28 12 reported report VBN cord-258230-s4ty52kb 28 13 that that IN cord-258230-s4ty52kb 28 14 co co NN cord-258230-s4ty52kb 28 15 - - JJ cord-258230-s4ty52kb 28 16 existing existing JJ cord-258230-s4ty52kb 28 17 conditions condition NNS cord-258230-s4ty52kb 28 18 , , , cord-258230-s4ty52kb 28 19 including include VBG cord-258230-s4ty52kb 28 20 hypertension hypertension NN cord-258230-s4ty52kb 28 21 , , , cord-258230-s4ty52kb 28 22 cardiac cardiac JJ cord-258230-s4ty52kb 28 23 diseases disease NNS cord-258230-s4ty52kb 28 24 , , , cord-258230-s4ty52kb 28 25 cerebrovascular cerebrovascular JJ cord-258230-s4ty52kb 28 26 diseases disease NNS cord-258230-s4ty52kb 28 27 , , , cord-258230-s4ty52kb 28 28 and and CC cord-258230-s4ty52kb 28 29 diabetes diabetes NN cord-258230-s4ty52kb 28 30 , , , cord-258230-s4ty52kb 28 31 were be VBD cord-258230-s4ty52kb 28 32 common common JJ cord-258230-s4ty52kb 28 33 among among IN cord-258230-s4ty52kb 28 34 patients patient NNS cord-258230-s4ty52kb 28 35 with with IN cord-258230-s4ty52kb 28 36 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 28 37 who who WP cord-258230-s4ty52kb 28 38 had have VBD cord-258230-s4ty52kb 28 39 severe severe JJ cord-258230-s4ty52kb 28 40 illness illness NN cord-258230-s4ty52kb 28 41 , , , cord-258230-s4ty52kb 28 42 were be VBD cord-258230-s4ty52kb 28 43 admitted admit VBN cord-258230-s4ty52kb 28 44 to to IN cord-258230-s4ty52kb 28 45 the the DT cord-258230-s4ty52kb 28 46 intensive intensive JJ cord-258230-s4ty52kb 28 47 care care NN cord-258230-s4ty52kb 28 48 unit unit NN cord-258230-s4ty52kb 28 49 ( ( -LRB- cord-258230-s4ty52kb 28 50 ICU ICU NNP cord-258230-s4ty52kb 28 51 ) ) -RRB- cord-258230-s4ty52kb 28 52 , , , cord-258230-s4ty52kb 28 53 received receive VBD cord-258230-s4ty52kb 28 54 mechanical mechanical JJ cord-258230-s4ty52kb 28 55 ventilation ventilation NN cord-258230-s4ty52kb 28 56 , , , cord-258230-s4ty52kb 28 57 or or CC cord-258230-s4ty52kb 28 58 died die VBD cord-258230-s4ty52kb 28 59 than than IN cord-258230-s4ty52kb 28 60 among among IN cord-258230-s4ty52kb 28 61 patients patient NNS cord-258230-s4ty52kb 28 62 who who WP cord-258230-s4ty52kb 28 63 had have VBD cord-258230-s4ty52kb 28 64 mild mild JJ cord-258230-s4ty52kb 28 65 illness illness NN cord-258230-s4ty52kb 28 66 . . . cord-258230-s4ty52kb 29 1 3 3 CD cord-258230-s4ty52kb 29 2 , , , cord-258230-s4ty52kb 29 3 4 4 CD cord-258230-s4ty52kb 29 4 Notably notably RB cord-258230-s4ty52kb 29 5 , , , cord-258230-s4ty52kb 29 6 of of IN cord-258230-s4ty52kb 29 7 the the DT cord-258230-s4ty52kb 29 8 most most RBS cord-258230-s4ty52kb 29 9 frequent frequent JJ cord-258230-s4ty52kb 29 10 comorbidities comorbiditie NNS cord-258230-s4ty52kb 29 11 reported report VBN cord-258230-s4ty52kb 29 12 in in IN cord-258230-s4ty52kb 29 13 these these DT cord-258230-s4ty52kb 29 14 studies study NNS cord-258230-s4ty52kb 29 15 of of IN cord-258230-s4ty52kb 29 16 patients patient NNS cord-258230-s4ty52kb 29 17 with with IN cord-258230-s4ty52kb 29 18 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 29 19 , , , cord-258230-s4ty52kb 29 20 hypertension hypertension NN cord-258230-s4ty52kb 29 21 in in IN cord-258230-s4ty52kb 29 22 particular particular JJ cord-258230-s4ty52kb 29 23 is be VBZ cord-258230-s4ty52kb 29 24 often often RB cord-258230-s4ty52kb 29 25 treated treat VBN cord-258230-s4ty52kb 29 26 with with IN cord-258230-s4ty52kb 29 27 angiotensin angiotensin NN cord-258230-s4ty52kb 29 28 - - HYPH cord-258230-s4ty52kb 29 29 converting convert VBG cord-258230-s4ty52kb 29 30 enzyme enzyme NN cord-258230-s4ty52kb 29 31 inhibitors inhibitor NNS cord-258230-s4ty52kb 29 32 ( ( -LRB- cord-258230-s4ty52kb 29 33 ACEIs acei NNS cord-258230-s4ty52kb 29 34 ) ) -RRB- cord-258230-s4ty52kb 29 35 and and CC cord-258230-s4ty52kb 29 36 angiotensin angiotensin NN cord-258230-s4ty52kb 29 37 receptor receptor NN cord-258230-s4ty52kb 29 38 blockers blocker NNS cord-258230-s4ty52kb 29 39 ( ( -LRB- cord-258230-s4ty52kb 29 40 ARBs arb NNS cord-258230-s4ty52kb 29 41 ) ) -RRB- cord-258230-s4ty52kb 29 42 . . . cord-258230-s4ty52kb 30 1 5 5 LS cord-258230-s4ty52kb 31 1 This this DT cord-258230-s4ty52kb 31 2 could could MD cord-258230-s4ty52kb 31 3 theoretically theoretically RB cord-258230-s4ty52kb 31 4 result result VB cord-258230-s4ty52kb 31 5 in in IN cord-258230-s4ty52kb 31 6 an an DT cord-258230-s4ty52kb 31 7 up up JJ cord-258230-s4ty52kb 31 8 - - HYPH cord-258230-s4ty52kb 31 9 regulation regulation NN cord-258230-s4ty52kb 31 10 of of IN cord-258230-s4ty52kb 31 11 ACE2 ACE2 NNP cord-258230-s4ty52kb 31 12 , , , cord-258230-s4ty52kb 31 13 which which WDT cord-258230-s4ty52kb 31 14 is be VBZ cord-258230-s4ty52kb 31 15 an an DT cord-258230-s4ty52kb 31 16 active active JJ cord-258230-s4ty52kb 31 17 binding binding NN cord-258230-s4ty52kb 31 18 target target NN cord-258230-s4ty52kb 31 19 for for IN cord-258230-s4ty52kb 31 20 SARS SARS NNP cord-258230-s4ty52kb 31 21 - - HYPH cord-258230-s4ty52kb 31 22 CoV-2 CoV-2 NNP cord-258230-s4ty52kb 31 23 virus virus NN cord-258230-s4ty52kb 31 24 , , , cord-258230-s4ty52kb 31 25 6 6 CD cord-258230-s4ty52kb 31 26 in in IN cord-258230-s4ty52kb 31 27 the the DT cord-258230-s4ty52kb 31 28 epithelial epithelial JJ cord-258230-s4ty52kb 31 29 cells cell NNS cord-258230-s4ty52kb 31 30 of of IN cord-258230-s4ty52kb 31 31 the the DT cord-258230-s4ty52kb 31 32 lung lung NN cord-258230-s4ty52kb 31 33 , , , cord-258230-s4ty52kb 31 34 intestine intestine NN cord-258230-s4ty52kb 31 35 , , , cord-258230-s4ty52kb 31 36 kidney kidney NN cord-258230-s4ty52kb 31 37 , , , cord-258230-s4ty52kb 31 38 and and CC cord-258230-s4ty52kb 31 39 blood blood NN cord-258230-s4ty52kb 31 40 vessels vessel NNS cord-258230-s4ty52kb 31 41 . . . cord-258230-s4ty52kb 32 1 Although although IN cord-258230-s4ty52kb 32 2 this this DT cord-258230-s4ty52kb 32 3 raised raise VBN cord-258230-s4ty52kb 32 4 concerns concern NNS cord-258230-s4ty52kb 32 5 regarding regard VBG cord-258230-s4ty52kb 32 6 the the DT cord-258230-s4ty52kb 32 7 use use NN cord-258230-s4ty52kb 32 8 of of IN cord-258230-s4ty52kb 32 9 these these DT cord-258230-s4ty52kb 32 10 drugs drug NNS cord-258230-s4ty52kb 32 11 in in IN cord-258230-s4ty52kb 32 12 COVID-19 covid-19 CD cord-258230-s4ty52kb 32 13 patients patient NNS cord-258230-s4ty52kb 32 14 , , , cord-258230-s4ty52kb 32 15 several several JJ cord-258230-s4ty52kb 32 16 animal animal NN cord-258230-s4ty52kb 32 17 studies study NNS cord-258230-s4ty52kb 32 18 presented present VBD cord-258230-s4ty52kb 32 19 conflicting conflicting JJ cord-258230-s4ty52kb 32 20 findings finding NNS cord-258230-s4ty52kb 32 21 regarding regard VBG cord-258230-s4ty52kb 32 22 increased increase VBN cord-258230-s4ty52kb 32 23 ACE2 ACE2 NNP cord-258230-s4ty52kb 32 24 expression expression NN cord-258230-s4ty52kb 32 25 due due IN cord-258230-s4ty52kb 32 26 to to IN cord-258230-s4ty52kb 32 27 ACEIs acei NNS cord-258230-s4ty52kb 32 28 and and CC cord-258230-s4ty52kb 32 29 ARBs arb NNS cord-258230-s4ty52kb 32 30 , , , cord-258230-s4ty52kb 32 31 and and CC cord-258230-s4ty52kb 32 32 previous previous JJ cord-258230-s4ty52kb 32 33 human human JJ cord-258230-s4ty52kb 32 34 studies study NNS cord-258230-s4ty52kb 32 35 suggested suggest VBD cord-258230-s4ty52kb 32 36 that that IN cord-258230-s4ty52kb 32 37 administration administration NN cord-258230-s4ty52kb 32 38 of of IN cord-258230-s4ty52kb 32 39 an an DT cord-258230-s4ty52kb 32 40 ACEI ACEI NNP cord-258230-s4ty52kb 32 41 / / SYM cord-258230-s4ty52kb 32 42 ARB ARB NNP cord-258230-s4ty52kb 32 43 does do VBZ cord-258230-s4ty52kb 32 44 not not RB cord-258230-s4ty52kb 32 45 increase increase VB cord-258230-s4ty52kb 32 46 ACE2 ACE2 NNP cord-258230-s4ty52kb 32 47 expression expression NN cord-258230-s4ty52kb 32 48 . . . cord-258230-s4ty52kb 33 1 7 7 CD cord-258230-s4ty52kb 34 1 In in IN cord-258230-s4ty52kb 34 2 light light NN cord-258230-s4ty52kb 34 3 of of IN cord-258230-s4ty52kb 34 4 these these DT cord-258230-s4ty52kb 34 5 findings finding NNS cord-258230-s4ty52kb 34 6 and and CC cord-258230-s4ty52kb 34 7 a a DT cord-258230-s4ty52kb 34 8 paucity paucity NN cord-258230-s4ty52kb 34 9 of of IN cord-258230-s4ty52kb 34 10 clinical clinical JJ cord-258230-s4ty52kb 34 11 outcome outcome NN cord-258230-s4ty52kb 34 12 studies study NNS cord-258230-s4ty52kb 34 13 , , , cord-258230-s4ty52kb 34 14 many many JJ cord-258230-s4ty52kb 34 15 professional professional JJ cord-258230-s4ty52kb 34 16 cardiovascular cardiovascular NN cord-258230-s4ty52kb 34 17 and and CC cord-258230-s4ty52kb 34 18 hypertension hypertension NN cord-258230-s4ty52kb 34 19 societies society NNS cord-258230-s4ty52kb 34 20 including include VBG cord-258230-s4ty52kb 34 21 the the DT cord-258230-s4ty52kb 34 22 European European NNP cord-258230-s4ty52kb 34 23 Society Society NNP cord-258230-s4ty52kb 34 24 of of IN cord-258230-s4ty52kb 34 25 Cardiology Cardiology NNP cord-258230-s4ty52kb 34 26 , , , cord-258230-s4ty52kb 34 27 Italian Italian NNP cord-258230-s4ty52kb 34 28 Society Society NNP cord-258230-s4ty52kb 34 29 of of IN cord-258230-s4ty52kb 34 30 Pharmacology Pharmacology NNP cord-258230-s4ty52kb 34 31 , , , cord-258230-s4ty52kb 34 32 International International NNP cord-258230-s4ty52kb 34 33 Society Society NNP cord-258230-s4ty52kb 34 34 of of IN cord-258230-s4ty52kb 34 35 Hypertension Hypertension NNP cord-258230-s4ty52kb 34 36 ( ( -LRB- cord-258230-s4ty52kb 34 37 ISH ISH NNP cord-258230-s4ty52kb 34 38 ) ) -RRB- cord-258230-s4ty52kb 34 39 , , , cord-258230-s4ty52kb 34 40 European European NNP cord-258230-s4ty52kb 34 41 Society Society NNP cord-258230-s4ty52kb 34 42 of of IN cord-258230-s4ty52kb 34 43 Hypertension Hypertension NNP cord-258230-s4ty52kb 34 44 , , , cord-258230-s4ty52kb 34 45 Joint Joint NNP cord-258230-s4ty52kb 34 46 American American NNP cord-258230-s4ty52kb 34 47 Heart Heart NNP cord-258230-s4ty52kb 34 48 Association Association NNP cord-258230-s4ty52kb 34 49 / / SYM cord-258230-s4ty52kb 34 50 American American NNP cord-258230-s4ty52kb 34 51 College College NNP cord-258230-s4ty52kb 34 52 of of IN cord-258230-s4ty52kb 34 53 Cardiology/ Cardiology/ NNP cord-258230-s4ty52kb 34 54 American American NNP cord-258230-s4ty52kb 34 55 Heart Heart NNP cord-258230-s4ty52kb 34 56 Failure Failure NNP cord-258230-s4ty52kb 34 57 Association Association NNP cord-258230-s4ty52kb 34 58 , , , cord-258230-s4ty52kb 34 59 and and CC cord-258230-s4ty52kb 34 60 others other NNS cord-258230-s4ty52kb 34 61 recommended recommend VBD cord-258230-s4ty52kb 34 62 the the DT cord-258230-s4ty52kb 34 63 continued continue VBN cord-258230-s4ty52kb 34 64 use use NN cord-258230-s4ty52kb 34 65 of of IN cord-258230-s4ty52kb 34 66 ACEIs acei NNS cord-258230-s4ty52kb 34 67 / / SYM cord-258230-s4ty52kb 34 68 ARBs arb NNS cord-258230-s4ty52kb 34 69 in in IN cord-258230-s4ty52kb 34 70 COVID-19 covid-19 CD cord-258230-s4ty52kb 34 71 patients patient NNS cord-258230-s4ty52kb 34 72 . . . cord-258230-s4ty52kb 35 1 [ [ -LRB- cord-258230-s4ty52kb 35 2 8 8 CD cord-258230-s4ty52kb 35 3 ] ] -RRB- cord-258230-s4ty52kb 35 4 [ [ -LRB- cord-258230-s4ty52kb 35 5 9 9 CD cord-258230-s4ty52kb 35 6 ] ] -RRB- cord-258230-s4ty52kb 35 7 [ [ -LRB- cord-258230-s4ty52kb 35 8 10 10 CD cord-258230-s4ty52kb 35 9 ] ] -RRB- cord-258230-s4ty52kb 35 10 [ [ -LRB- cord-258230-s4ty52kb 35 11 11 11 CD cord-258230-s4ty52kb 35 12 ] ] -RRB- cord-258230-s4ty52kb 36 1 [ [ -LRB- cord-258230-s4ty52kb 36 2 12 12 CD cord-258230-s4ty52kb 36 3 ] ] -RRB- cord-258230-s4ty52kb 37 1 However however RB cord-258230-s4ty52kb 37 2 , , , cord-258230-s4ty52kb 37 3 since since IN cord-258230-s4ty52kb 37 4 the the DT cord-258230-s4ty52kb 37 5 conception conception NN cord-258230-s4ty52kb 37 6 of of IN cord-258230-s4ty52kb 37 7 these these DT cord-258230-s4ty52kb 37 8 recommendations recommendation NNS cord-258230-s4ty52kb 37 9 , , , cord-258230-s4ty52kb 37 10 several several JJ cord-258230-s4ty52kb 37 11 clinical clinical JJ cord-258230-s4ty52kb 37 12 studies study NNS cord-258230-s4ty52kb 37 13 have have VBP cord-258230-s4ty52kb 37 14 been be VBN cord-258230-s4ty52kb 37 15 conducted conduct VBN cord-258230-s4ty52kb 37 16 which which WDT cord-258230-s4ty52kb 37 17 evaluated evaluate VBD cord-258230-s4ty52kb 37 18 the the DT cord-258230-s4ty52kb 37 19 association association NN cord-258230-s4ty52kb 37 20 of of IN cord-258230-s4ty52kb 37 21 ACEIs acei NNS cord-258230-s4ty52kb 37 22 and and CC cord-258230-s4ty52kb 37 23 ARBs arb NNS cord-258230-s4ty52kb 37 24 with with IN cord-258230-s4ty52kb 37 25 clinical clinical JJ cord-258230-s4ty52kb 37 26 severity severity NN cord-258230-s4ty52kb 37 27 and and CC cord-258230-s4ty52kb 37 28 mortality mortality NN cord-258230-s4ty52kb 37 29 outcomes outcome NNS cord-258230-s4ty52kb 37 30 in in IN cord-258230-s4ty52kb 37 31 COVID-19 covid-19 JJ cord-258230-s4ty52kb 37 32 patients patient NNS cord-258230-s4ty52kb 37 33 . . . cord-258230-s4ty52kb 38 1 Therefore therefore RB cord-258230-s4ty52kb 38 2 , , , cord-258230-s4ty52kb 38 3 the the DT cord-258230-s4ty52kb 38 4 medical medical JJ cord-258230-s4ty52kb 38 5 literature literature NN cord-258230-s4ty52kb 38 6 was be VBD cord-258230-s4ty52kb 38 7 systematically systematically RB cord-258230-s4ty52kb 38 8 reviewed review VBN cord-258230-s4ty52kb 38 9 , , , cord-258230-s4ty52kb 38 10 and and CC cord-258230-s4ty52kb 38 11 a a DT cord-258230-s4ty52kb 38 12 meta meta JJ cord-258230-s4ty52kb 38 13 - - HYPH cord-258230-s4ty52kb 38 14 analysis analysis NN cord-258230-s4ty52kb 38 15 was be VBD cord-258230-s4ty52kb 38 16 performed perform VBN cord-258230-s4ty52kb 38 17 of of IN cord-258230-s4ty52kb 38 18 the the DT cord-258230-s4ty52kb 38 19 current current JJ cord-258230-s4ty52kb 38 20 clinical clinical JJ cord-258230-s4ty52kb 38 21 studies study NNS cord-258230-s4ty52kb 38 22 evaluating evaluate VBG cord-258230-s4ty52kb 38 23 the the DT cord-258230-s4ty52kb 38 24 safety safety NN cord-258230-s4ty52kb 38 25 and and CC cord-258230-s4ty52kb 38 26 efficacy efficacy NN cord-258230-s4ty52kb 38 27 of of IN cord-258230-s4ty52kb 38 28 ACEs ace NNS cord-258230-s4ty52kb 38 29 and and CC cord-258230-s4ty52kb 38 30 ARBs arb NNS cord-258230-s4ty52kb 38 31 in in IN cord-258230-s4ty52kb 38 32 COVID-19 covid-19 CD cord-258230-s4ty52kb 38 33 patients patient NNS cord-258230-s4ty52kb 38 34 . . . cord-258230-s4ty52kb 39 1 A a DT cord-258230-s4ty52kb 39 2 literature literature NN cord-258230-s4ty52kb 39 3 search search NN cord-258230-s4ty52kb 39 4 was be VBD cord-258230-s4ty52kb 39 5 conducted conduct VBN cord-258230-s4ty52kb 39 6 on on IN cord-258230-s4ty52kb 39 7 the the DT cord-258230-s4ty52kb 39 8 PubMed PubMed NNP cord-258230-s4ty52kb 39 9 / / SYM cord-258230-s4ty52kb 39 10 MEDLINE MEDLINE NNP cord-258230-s4ty52kb 39 11 database database NN cord-258230-s4ty52kb 39 12 using use VBG cord-258230-s4ty52kb 39 13 keywords keyword NNS cord-258230-s4ty52kb 39 14 , , , cord-258230-s4ty52kb 39 15 i.e. i.e. FW cord-258230-s4ty52kb 39 16 ' ' '' cord-258230-s4ty52kb 39 17 ACE ace NN cord-258230-s4ty52kb 39 18 inhibitors inhibitor NNS cord-258230-s4ty52kb 39 19 AND and CC cord-258230-s4ty52kb 39 20 COVID COVID NNP cord-258230-s4ty52kb 39 21 ' ' '' cord-258230-s4ty52kb 39 22 and and CC cord-258230-s4ty52kb 39 23 ' ' `` cord-258230-s4ty52kb 39 24 ARB ARB NNP cord-258230-s4ty52kb 39 25 AND and CC cord-258230-s4ty52kb 39 26 COVID COVID NNP cord-258230-s4ty52kb 39 27 ' ' '' cord-258230-s4ty52kb 39 28 . . . cord-258230-s4ty52kb 40 1 We -PRON- PRP cord-258230-s4ty52kb 40 2 applied apply VBD cord-258230-s4ty52kb 40 3 search search NN cord-258230-s4ty52kb 40 4 filters filter NNS cord-258230-s4ty52kb 40 5 to to TO cord-258230-s4ty52kb 40 6 include include VB cord-258230-s4ty52kb 40 7 humans human NNS cord-258230-s4ty52kb 40 8 and and CC cord-258230-s4ty52kb 40 9 English english JJ cord-258230-s4ty52kb 40 10 language language NN cord-258230-s4ty52kb 40 11 studies study NNS cord-258230-s4ty52kb 40 12 published publish VBN cord-258230-s4ty52kb 40 13 up up RP cord-258230-s4ty52kb 40 14 to to IN cord-258230-s4ty52kb 40 15 1 1 CD cord-258230-s4ty52kb 40 16 May May NNP cord-258230-s4ty52kb 40 17 2020 2020 CD cord-258230-s4ty52kb 40 18 . . . cord-258230-s4ty52kb 41 1 Additional additional JJ cord-258230-s4ty52kb 41 2 papers paper NNS cord-258230-s4ty52kb 41 3 of of IN cord-258230-s4ty52kb 41 4 possible possible JJ cord-258230-s4ty52kb 41 5 interest interest NN cord-258230-s4ty52kb 41 6 were be VBD cord-258230-s4ty52kb 41 7 identified identify VBN cord-258230-s4ty52kb 41 8 by by IN cord-258230-s4ty52kb 41 9 examining examine VBG cord-258230-s4ty52kb 41 10 references reference NNS cord-258230-s4ty52kb 41 11 of of IN cord-258230-s4ty52kb 41 12 pertinent pertinent JJ cord-258230-s4ty52kb 41 13 review review NN cord-258230-s4ty52kb 41 14 articles article NNS cord-258230-s4ty52kb 41 15 and and CC cord-258230-s4ty52kb 41 16 searching search VBG cord-258230-s4ty52kb 41 17 Google Google NNP cord-258230-s4ty52kb 41 18 Scholar scholar NN cord-258230-s4ty52kb 41 19 and and CC cord-258230-s4ty52kb 41 20 preprint preprint NN cord-258230-s4ty52kb 41 21 servers server NNS cord-258230-s4ty52kb 41 22 such such JJ cord-258230-s4ty52kb 41 23 as as IN cord-258230-s4ty52kb 41 24 MedRxiv MedRxiv NNP cord-258230-s4ty52kb 41 25 and and CC cord-258230-s4ty52kb 41 26 BioRxiv BioRxiv NNP cord-258230-s4ty52kb 41 27 . . . cord-258230-s4ty52kb 42 1 We -PRON- PRP cord-258230-s4ty52kb 42 2 included include VBD cord-258230-s4ty52kb 42 3 studies study NNS cord-258230-s4ty52kb 42 4 which which WDT cord-258230-s4ty52kb 42 5 evaluated evaluate VBD cord-258230-s4ty52kb 42 6 clinical clinical JJ cord-258230-s4ty52kb 42 7 severity severity NN cord-258230-s4ty52kb 42 8 and and CC cord-258230-s4ty52kb 42 9 mortality mortality NN cord-258230-s4ty52kb 42 10 outcomes outcome NNS cord-258230-s4ty52kb 42 11 for for IN cord-258230-s4ty52kb 42 12 patients patient NNS cord-258230-s4ty52kb 42 13 with with IN cord-258230-s4ty52kb 42 14 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 42 15 on on IN cord-258230-s4ty52kb 42 16 an an DT cord-258230-s4ty52kb 42 17 ACEI ACEI NNP cord-258230-s4ty52kb 42 18 , , , cord-258230-s4ty52kb 42 19 an an DT cord-258230-s4ty52kb 42 20 ARB arb NN cord-258230-s4ty52kb 42 21 , , , cord-258230-s4ty52kb 42 22 or or CC cord-258230-s4ty52kb 42 23 both both DT cord-258230-s4ty52kb 42 24 . . . cord-258230-s4ty52kb 43 1 We -PRON- PRP cord-258230-s4ty52kb 43 2 excluded exclude VBD cord-258230-s4ty52kb 43 3 those those DT cord-258230-s4ty52kb 43 4 studies study NNS cord-258230-s4ty52kb 43 5 which which WDT cord-258230-s4ty52kb 43 6 were be VBD cord-258230-s4ty52kb 43 7 in in IN cord-258230-s4ty52kb 43 8 vitro vitro FW cord-258230-s4ty52kb 43 9 or or CC cord-258230-s4ty52kb 43 10 conducted conduct VBN cord-258230-s4ty52kb 43 11 in in IN cord-258230-s4ty52kb 43 12 animal animal NN cord-258230-s4ty52kb 43 13 models model NNS cord-258230-s4ty52kb 43 14 , , , cord-258230-s4ty52kb 43 15 as as RB cord-258230-s4ty52kb 43 16 well well RB cord-258230-s4ty52kb 43 17 as as IN cord-258230-s4ty52kb 43 18 those those DT cord-258230-s4ty52kb 43 19 human human JJ cord-258230-s4ty52kb 43 20 studies study NNS cord-258230-s4ty52kb 43 21 which which WDT cord-258230-s4ty52kb 43 22 evaluated evaluate VBD cord-258230-s4ty52kb 43 23 only only RB cord-258230-s4ty52kb 43 24 ACE ace NN cord-258230-s4ty52kb 43 25 expression expression NN cord-258230-s4ty52kb 43 26 levels level NNS cord-258230-s4ty52kb 43 27 ( ( -LRB- cord-258230-s4ty52kb 43 28 Figure figure NN cord-258230-s4ty52kb 43 29 1 1 CD cord-258230-s4ty52kb 43 30 ) ) -RRB- cord-258230-s4ty52kb 43 31 . . . cord-258230-s4ty52kb 44 1 Information information NN cord-258230-s4ty52kb 44 2 on on IN cord-258230-s4ty52kb 44 3 the the DT cord-258230-s4ty52kb 44 4 demographics demographic NNS cord-258230-s4ty52kb 44 5 , , , cord-258230-s4ty52kb 44 6 comorbidities comorbiditie NNS cord-258230-s4ty52kb 44 7 , , , cord-258230-s4ty52kb 44 8 and and CC cord-258230-s4ty52kb 44 9 pharmacotherapy pharmacotherapy NN cord-258230-s4ty52kb 44 10 with with IN cord-258230-s4ty52kb 44 11 ACEIs acei NNS cord-258230-s4ty52kb 44 12 , , , cord-258230-s4ty52kb 44 13 ARBs arb NNS cord-258230-s4ty52kb 44 14 , , , cord-258230-s4ty52kb 44 15 and and CC cord-258230-s4ty52kb 44 16 other other JJ cord-258230-s4ty52kb 44 17 drugs drug NNS cord-258230-s4ty52kb 44 18 , , , cord-258230-s4ty52kb 44 19 clinical clinical JJ cord-258230-s4ty52kb 44 20 severity severity NN cord-258230-s4ty52kb 44 21 outcomes outcome NNS cord-258230-s4ty52kb 44 22 , , , cord-258230-s4ty52kb 44 23 and and CC cord-258230-s4ty52kb 44 24 mortality mortality NN cord-258230-s4ty52kb 44 25 was be VBD cord-258230-s4ty52kb 44 26 extracted extract VBN cord-258230-s4ty52kb 44 27 . . . cord-258230-s4ty52kb 45 1 The the DT cord-258230-s4ty52kb 45 2 meta meta JJ cord-258230-s4ty52kb 45 3 - - HYPH cord-258230-s4ty52kb 45 4 analysis analysis NN cord-258230-s4ty52kb 45 5 for for IN cord-258230-s4ty52kb 45 6 severity severity NN cord-258230-s4ty52kb 45 7 and and CC cord-258230-s4ty52kb 45 8 mortality mortality NN cord-258230-s4ty52kb 45 9 was be VBD cord-258230-s4ty52kb 45 10 conducted conduct VBN cord-258230-s4ty52kb 45 11 for for IN cord-258230-s4ty52kb 45 12 four four CD cord-258230-s4ty52kb 45 13 and and CC cord-258230-s4ty52kb 45 14 six six CD cord-258230-s4ty52kb 45 15 peer peer NN cord-258230-s4ty52kb 45 16 - - HYPH cord-258230-s4ty52kb 45 17 reviewed review VBN cord-258230-s4ty52kb 45 18 studies study NNS cord-258230-s4ty52kb 45 19 , , , cord-258230-s4ty52kb 45 20 respectively respectively RB cord-258230-s4ty52kb 45 21 , , , cord-258230-s4ty52kb 45 22 using use VBG cord-258230-s4ty52kb 45 23 the the DT cord-258230-s4ty52kb 45 24 comprehensive comprehensive JJ cord-258230-s4ty52kb 45 25 metaanalysis metaanalysis NN cord-258230-s4ty52kb 45 26 ( ( -LRB- cord-258230-s4ty52kb 45 27 CMA CMA NNP cord-258230-s4ty52kb 45 28 ) ) -RRB- cord-258230-s4ty52kb 45 29 software software NN cord-258230-s4ty52kb 45 30 version version NN cord-258230-s4ty52kb 45 31 3 3 CD cord-258230-s4ty52kb 45 32 ( ( -LRB- cord-258230-s4ty52kb 45 33 Biostat Biostat NNP cord-258230-s4ty52kb 45 34 Inc. Inc. NNP cord-258230-s4ty52kb 45 35 , , , cord-258230-s4ty52kb 45 36 Englewood Englewood NNP cord-258230-s4ty52kb 45 37 , , , cord-258230-s4ty52kb 45 38 NJ NJ NNP cord-258230-s4ty52kb 45 39 , , , cord-258230-s4ty52kb 45 40 USA USA NNP cord-258230-s4ty52kb 45 41 ) ) -RRB- cord-258230-s4ty52kb 45 42 . . . cord-258230-s4ty52kb 46 1 The the DT cord-258230-s4ty52kb 46 2 studies study NNS cord-258230-s4ty52kb 46 3 were be VBD cord-258230-s4ty52kb 46 4 assessed assess VBN cord-258230-s4ty52kb 46 5 for for IN cord-258230-s4ty52kb 46 6 methodological methodological JJ cord-258230-s4ty52kb 46 7 quality quality NN cord-258230-s4ty52kb 46 8 based base VBN cord-258230-s4ty52kb 46 9 on on IN cord-258230-s4ty52kb 46 10 the the DT cord-258230-s4ty52kb 46 11 Newcastle Newcastle NNP cord-258230-s4ty52kb 46 12 - - HYPH cord-258230-s4ty52kb 46 13 Ottawa Ottawa NNP cord-258230-s4ty52kb 46 14 Scale Scale NNP cord-258230-s4ty52kb 46 15 ( ( -LRB- cord-258230-s4ty52kb 46 16 NOS NOS NNP cord-258230-s4ty52kb 46 17 ) ) -RRB- cord-258230-s4ty52kb 46 18 . . . cord-258230-s4ty52kb 47 1 13 13 CD cord-258230-s4ty52kb 48 1 The the DT cord-258230-s4ty52kb 48 2 NOS NOS NNP cord-258230-s4ty52kb 48 3 has have VBZ cord-258230-s4ty52kb 48 4 eight eight CD cord-258230-s4ty52kb 48 5 criteria criterion NNS cord-258230-s4ty52kb 48 6 and and CC cord-258230-s4ty52kb 48 7 generates generate VBZ cord-258230-s4ty52kb 48 8 scores score NNS cord-258230-s4ty52kb 48 9 ranging range VBG cord-258230-s4ty52kb 48 10 from from IN cord-258230-s4ty52kb 48 11 0 0 CD cord-258230-s4ty52kb 48 12 ( ( -LRB- cord-258230-s4ty52kb 48 13 high high JJ cord-258230-s4ty52kb 48 14 risk risk NN cord-258230-s4ty52kb 48 15 of of IN cord-258230-s4ty52kb 48 16 bias bias NN cord-258230-s4ty52kb 48 17 ) ) -RRB- cord-258230-s4ty52kb 48 18 to to IN cord-258230-s4ty52kb 48 19 9 9 CD cord-258230-s4ty52kb 48 20 ( ( -LRB- cord-258230-s4ty52kb 48 21 low low JJ cord-258230-s4ty52kb 48 22 risk risk NN cord-258230-s4ty52kb 48 23 of of IN cord-258230-s4ty52kb 48 24 bias bias NN cord-258230-s4ty52kb 48 25 ) ) -RRB- cord-258230-s4ty52kb 48 26 . . . cord-258230-s4ty52kb 49 1 Studies study NNS cord-258230-s4ty52kb 49 2 with with IN cord-258230-s4ty52kb 49 3 NOS NOS NNP cord-258230-s4ty52kb 49 4 scores score NNS cord-258230-s4ty52kb 49 5 of of IN cord-258230-s4ty52kb 49 6 > > SYM cord-258230-s4ty52kb 49 7 7 7 CD cord-258230-s4ty52kb 49 8 were be VBD cord-258230-s4ty52kb 49 9 regarded regard VBN cord-258230-s4ty52kb 49 10 as as IN cord-258230-s4ty52kb 49 11 high high JJ cord-258230-s4ty52kb 49 12 quality quality NN cord-258230-s4ty52kb 49 13 . . . cord-258230-s4ty52kb 50 1 Heterogeneity heterogeneity NN cord-258230-s4ty52kb 50 2 was be VBD cord-258230-s4ty52kb 50 3 assessed assess VBN cord-258230-s4ty52kb 50 4 using use VBG cord-258230-s4ty52kb 50 5 the the DT cord-258230-s4ty52kb 50 6 Higgin Higgin NNP cord-258230-s4ty52kb 50 7 's 's POS cord-258230-s4ty52kb 50 8 I i NN cord-258230-s4ty52kb 50 9 2 2 CD cord-258230-s4ty52kb 50 10 test test NN cord-258230-s4ty52kb 50 11 , , , cord-258230-s4ty52kb 50 12 and and CC cord-258230-s4ty52kb 50 13 the the DT cord-258230-s4ty52kb 50 14 choice choice NN cord-258230-s4ty52kb 50 15 of of IN cord-258230-s4ty52kb 50 16 fixed fixed JJ cord-258230-s4ty52kb 50 17 or or CC cord-258230-s4ty52kb 50 18 random random JJ cord-258230-s4ty52kb 50 19 effects effect NNS cord-258230-s4ty52kb 50 20 model model NN cord-258230-s4ty52kb 50 21 was be VBD cord-258230-s4ty52kb 50 22 made make VBN cord-258230-s4ty52kb 50 23 based base VBN cord-258230-s4ty52kb 50 24 on on IN cord-258230-s4ty52kb 50 25 the the DT cord-258230-s4ty52kb 50 26 calculated calculate VBN cord-258230-s4ty52kb 50 27 heterogeneity heterogeneity NN cord-258230-s4ty52kb 50 28 . . . cord-258230-s4ty52kb 51 1 The the DT cord-258230-s4ty52kb 51 2 publication publication NN cord-258230-s4ty52kb 51 3 bias bias NN cord-258230-s4ty52kb 51 4 was be VBD cord-258230-s4ty52kb 51 5 reported report VBN cord-258230-s4ty52kb 51 6 by by IN cord-258230-s4ty52kb 51 7 using use VBG cord-258230-s4ty52kb 51 8 funnel funnel NN cord-258230-s4ty52kb 51 9 plots plot NNS cord-258230-s4ty52kb 51 10 . . . cord-258230-s4ty52kb 52 1 We -PRON- PRP cord-258230-s4ty52kb 52 2 reported report VBD cord-258230-s4ty52kb 52 3 the the DT cord-258230-s4ty52kb 52 4 findings finding NNS cord-258230-s4ty52kb 52 5 based base VBN cord-258230-s4ty52kb 52 6 on on IN cord-258230-s4ty52kb 52 7 both both CC cord-258230-s4ty52kb 52 8 a a DT cord-258230-s4ty52kb 52 9 fixed fixed JJ cord-258230-s4ty52kb 52 10 and and CC cord-258230-s4ty52kb 52 11 random random JJ cord-258230-s4ty52kb 52 12 effects effect NNS cord-258230-s4ty52kb 52 13 model model NN cord-258230-s4ty52kb 52 14 derived derive VBN cord-258230-s4ty52kb 52 15 from from IN cord-258230-s4ty52kb 52 16 the the DT cord-258230-s4ty52kb 52 17 heterogeneity heterogeneity NN cord-258230-s4ty52kb 52 18 of of IN cord-258230-s4ty52kb 52 19 the the DT cord-258230-s4ty52kb 52 20 studies study NNS cord-258230-s4ty52kb 52 21 . . . cord-258230-s4ty52kb 53 1 A a DT cord-258230-s4ty52kb 53 2 total total NN cord-258230-s4ty52kb 53 3 of of IN cord-258230-s4ty52kb 53 4 276 276 CD cord-258230-s4ty52kb 53 5 articles article NNS cord-258230-s4ty52kb 53 6 were be VBD cord-258230-s4ty52kb 53 7 found find VBN cord-258230-s4ty52kb 53 8 in in IN cord-258230-s4ty52kb 53 9 the the DT cord-258230-s4ty52kb 53 10 search search NN cord-258230-s4ty52kb 53 11 . . . cord-258230-s4ty52kb 54 1 Based base VBN cord-258230-s4ty52kb 54 2 on on IN cord-258230-s4ty52kb 54 3 the the DT cord-258230-s4ty52kb 54 4 screening screening NN cord-258230-s4ty52kb 54 5 of of IN cord-258230-s4ty52kb 54 6 titles title NNS cord-258230-s4ty52kb 54 7 of of IN cord-258230-s4ty52kb 54 8 the the DT cord-258230-s4ty52kb 54 9 articles article NNS cord-258230-s4ty52kb 54 10 , , , cord-258230-s4ty52kb 54 11 178 178 CD cord-258230-s4ty52kb 54 12 were be VBD cord-258230-s4ty52kb 54 13 excluded exclude VBN cord-258230-s4ty52kb 54 14 as as IN cord-258230-s4ty52kb 54 15 they -PRON- PRP cord-258230-s4ty52kb 54 16 did do VBD cord-258230-s4ty52kb 54 17 not not RB cord-258230-s4ty52kb 54 18 meet meet VB cord-258230-s4ty52kb 54 19 the the DT cord-258230-s4ty52kb 54 20 inclusion inclusion NN cord-258230-s4ty52kb 54 21 criteria criterion NNS cord-258230-s4ty52kb 54 22 . . . cord-258230-s4ty52kb 55 1 Further further RB cord-258230-s4ty52kb 55 2 , , , cord-258230-s4ty52kb 55 3 abstracts abstract NNS cord-258230-s4ty52kb 55 4 of of IN cord-258230-s4ty52kb 55 5 98 98 CD cord-258230-s4ty52kb 55 6 articles article NNS cord-258230-s4ty52kb 55 7 were be VBD cord-258230-s4ty52kb 55 8 read read VBN cord-258230-s4ty52kb 55 9 and and CC cord-258230-s4ty52kb 55 10 , , , cord-258230-s4ty52kb 55 11 subsequently subsequently RB cord-258230-s4ty52kb 55 12 , , , cord-258230-s4ty52kb 55 13 the the DT cord-258230-s4ty52kb 55 14 full full JJ cord-258230-s4ty52kb 55 15 text text NN cord-258230-s4ty52kb 55 16 of of IN cord-258230-s4ty52kb 55 17 41 41 CD cord-258230-s4ty52kb 55 18 articles article NNS cord-258230-s4ty52kb 55 19 were be VBD cord-258230-s4ty52kb 55 20 reviewed review VBN cord-258230-s4ty52kb 55 21 . . . cord-258230-s4ty52kb 56 1 Of of IN cord-258230-s4ty52kb 56 2 these these DT cord-258230-s4ty52kb 56 3 , , , cord-258230-s4ty52kb 56 4 16 16 CD cord-258230-s4ty52kb 56 5 articles article NNS cord-258230-s4ty52kb 56 6 were be VBD cord-258230-s4ty52kb 56 7 shortlisted shortlist VBN cord-258230-s4ty52kb 56 8 which which WDT cord-258230-s4ty52kb 56 9 compared compare VBD cord-258230-s4ty52kb 56 10 the the DT cord-258230-s4ty52kb 56 11 clinical clinical JJ cord-258230-s4ty52kb 56 12 and/or and/or CC cord-258230-s4ty52kb 56 13 mortality mortality NN cord-258230-s4ty52kb 56 14 outcomes outcome NNS cord-258230-s4ty52kb 56 15 of of IN cord-258230-s4ty52kb 56 16 COVID-19 covid-19 JJ cord-258230-s4ty52kb 56 17 patients patient NNS cord-258230-s4ty52kb 56 18 on on IN cord-258230-s4ty52kb 56 19 an an DT cord-258230-s4ty52kb 56 20 ACEI ACEI NNP cord-258230-s4ty52kb 56 21 or or CC cord-258230-s4ty52kb 56 22 ARB ARB NNP cord-258230-s4ty52kb 56 23 with with IN cord-258230-s4ty52kb 56 24 nonusers nonuser NNS cord-258230-s4ty52kb 56 25 . . . cord-258230-s4ty52kb 57 1 [ [ -LRB- cord-258230-s4ty52kb 57 2 14 14 CD cord-258230-s4ty52kb 57 3 ] ] -RRB- cord-258230-s4ty52kb 57 4 [ [ -LRB- cord-258230-s4ty52kb 57 5 15 15 CD cord-258230-s4ty52kb 57 6 ] ] -RRB- cord-258230-s4ty52kb 57 7 [ [ -LRB- cord-258230-s4ty52kb 57 8 16 16 CD cord-258230-s4ty52kb 57 9 ] ] -RRB- cord-258230-s4ty52kb 57 10 [ [ -LRB- cord-258230-s4ty52kb 57 11 17 17 CD cord-258230-s4ty52kb 57 12 ] ] -RRB- cord-258230-s4ty52kb 57 13 [ [ -LRB- cord-258230-s4ty52kb 57 14 18 18 CD cord-258230-s4ty52kb 57 15 ] ] -RRB- cord-258230-s4ty52kb 57 16 [ [ -LRB- cord-258230-s4ty52kb 57 17 19 19 CD cord-258230-s4ty52kb 57 18 ] ] -RRB- cord-258230-s4ty52kb 58 1 [ [ -LRB- cord-258230-s4ty52kb 58 2 20 20 CD cord-258230-s4ty52kb 58 3 ] ] -RRB- cord-258230-s4ty52kb 58 4 [ [ -LRB- cord-258230-s4ty52kb 58 5 21 21 CD cord-258230-s4ty52kb 58 6 ] ] -RRB- cord-258230-s4ty52kb 59 1 [ [ -LRB- cord-258230-s4ty52kb 59 2 22 22 CD cord-258230-s4ty52kb 59 3 ] ] -RRB- cord-258230-s4ty52kb 59 4 [ [ -LRB- cord-258230-s4ty52kb 59 5 23 23 CD cord-258230-s4ty52kb 59 6 ] ] -RRB- cord-258230-s4ty52kb 60 1 [ [ -LRB- cord-258230-s4ty52kb 60 2 24 24 CD cord-258230-s4ty52kb 60 3 ] ] -RRB- cord-258230-s4ty52kb 60 4 [ [ -LRB- cord-258230-s4ty52kb 60 5 25 25 CD cord-258230-s4ty52kb 60 6 ] ] -RRB- cord-258230-s4ty52kb 60 7 [ [ -LRB- cord-258230-s4ty52kb 60 8 26 26 CD cord-258230-s4ty52kb 60 9 ] ] -RRB- cord-258230-s4ty52kb 60 10 [ [ -LRB- cord-258230-s4ty52kb 60 11 27 27 CD cord-258230-s4ty52kb 60 12 ] ] -RRB- cord-258230-s4ty52kb 61 1 [ [ -LRB- cord-258230-s4ty52kb 61 2 28 28 CD cord-258230-s4ty52kb 61 3 ] ] -RRB- cord-258230-s4ty52kb 62 1 [ [ -LRB- cord-258230-s4ty52kb 62 2 29 29 CD cord-258230-s4ty52kb 62 3 ] ] -RRB- cord-258230-s4ty52kb 63 1 Finally finally RB cord-258230-s4ty52kb 63 2 , , , cord-258230-s4ty52kb 63 3 these these DT cord-258230-s4ty52kb 63 4 16 16 CD cord-258230-s4ty52kb 63 5 studies study NNS cord-258230-s4ty52kb 63 6 were be VBD cord-258230-s4ty52kb 63 7 included include VBN cord-258230-s4ty52kb 63 8 for for IN cord-258230-s4ty52kb 63 9 review review NN cord-258230-s4ty52kb 63 10 and and CC cord-258230-s4ty52kb 63 11 , , , cord-258230-s4ty52kb 63 12 out out IN cord-258230-s4ty52kb 63 13 of of IN cord-258230-s4ty52kb 63 14 these these DT cord-258230-s4ty52kb 63 15 , , , cord-258230-s4ty52kb 63 16 six six CD cord-258230-s4ty52kb 63 17 and and CC cord-258230-s4ty52kb 63 18 four four CD cord-258230-s4ty52kb 63 19 studies study NNS cord-258230-s4ty52kb 63 20 were be VBD cord-258230-s4ty52kb 63 21 included include VBN cord-258230-s4ty52kb 63 22 in in IN cord-258230-s4ty52kb 63 23 the the DT cord-258230-s4ty52kb 63 24 meta meta NNP cord-258230-s4ty52kb 63 25 - - HYPH cord-258230-s4ty52kb 63 26 analysis analysis NN cord-258230-s4ty52kb 63 27 of of IN cord-258230-s4ty52kb 63 28 mortality mortality NN cord-258230-s4ty52kb 63 29 and and CC cord-258230-s4ty52kb 63 30 severity severity NN cord-258230-s4ty52kb 63 31 outcomes outcome NNS cord-258230-s4ty52kb 63 32 in in IN cord-258230-s4ty52kb 63 33 COVID-19 covid-19 JJ cord-258230-s4ty52kb 63 34 patients patient NNS cord-258230-s4ty52kb 63 35 on on IN cord-258230-s4ty52kb 63 36 an an DT cord-258230-s4ty52kb 63 37 ACEI/ ACEI/ NNP cord-258230-s4ty52kb 63 38 ARB ARB NNP cord-258230-s4ty52kb 63 39 , , , cord-258230-s4ty52kb 63 40 respectively respectively RB cord-258230-s4ty52kb 63 41 ( ( -LRB- cord-258230-s4ty52kb 63 42 Table table NN cord-258230-s4ty52kb 63 43 1 1 CD cord-258230-s4ty52kb 63 44 ) ) -RRB- cord-258230-s4ty52kb 63 45 . . . cord-258230-s4ty52kb 64 1 14 14 CD cord-258230-s4ty52kb 64 2 , , , cord-258230-s4ty52kb 64 3 20 20 CD cord-258230-s4ty52kb 64 4 , , , cord-258230-s4ty52kb 64 5 [ [ -LRB- cord-258230-s4ty52kb 64 6 22 22 CD cord-258230-s4ty52kb 64 7 ] ] -RRB- cord-258230-s4ty52kb 64 8 [ [ -LRB- cord-258230-s4ty52kb 64 9 23 23 CD cord-258230-s4ty52kb 64 10 ] ] -RRB- cord-258230-s4ty52kb 64 11 [ [ -LRB- cord-258230-s4ty52kb 64 12 24 24 CD cord-258230-s4ty52kb 64 13 ] ] -RRB- cord-258230-s4ty52kb 64 14 27 27 CD cord-258230-s4ty52kb 64 15 ( ( -LRB- cord-258230-s4ty52kb 64 16 Table table NN cord-258230-s4ty52kb 64 17 2 2 CD cord-258230-s4ty52kb 64 18 ) ) -RRB- cord-258230-s4ty52kb 64 19 Table table NN cord-258230-s4ty52kb 64 20 2 2 CD cord-258230-s4ty52kb 64 21 ) ) -RRB- cord-258230-s4ty52kb 64 22 . . . cord-258230-s4ty52kb 65 1 In in IN cord-258230-s4ty52kb 65 2 a a DT cord-258230-s4ty52kb 65 3 pooled pool VBN cord-258230-s4ty52kb 65 4 analysis analysis NN cord-258230-s4ty52kb 65 5 of of IN cord-258230-s4ty52kb 65 6 four four CD cord-258230-s4ty52kb 65 7 peer peer NN cord-258230-s4ty52kb 65 8 - - HYPH cord-258230-s4ty52kb 65 9 reviewed review VBN cord-258230-s4ty52kb 65 10 studies study NNS cord-258230-s4ty52kb 65 11 , , , cord-258230-s4ty52kb 65 12 there there EX cord-258230-s4ty52kb 65 13 was be VBD cord-258230-s4ty52kb 65 14 a a DT cord-258230-s4ty52kb 65 15 statistically statistically RB cord-258230-s4ty52kb 65 16 non non JJ cord-258230-s4ty52kb 65 17 - - JJ cord-258230-s4ty52kb 65 18 significant significant JJ cord-258230-s4ty52kb 65 19 association association NN cord-258230-s4ty52kb 65 20 of of IN cord-258230-s4ty52kb 65 21 an an DT cord-258230-s4ty52kb 65 22 ACEI ACEI NNP cord-258230-s4ty52kb 65 23 / / SYM cord-258230-s4ty52kb 65 24 ARB ARB NNP cord-258230-s4ty52kb 65 25 with with IN cord-258230-s4ty52kb 65 26 lower low JJR cord-258230-s4ty52kb 65 27 odds odd NNS cord-258230-s4ty52kb 65 28 of of IN cord-258230-s4ty52kb 65 29 developing develop VBG cord-258230-s4ty52kb 65 30 severe severe JJ cord-258230-s4ty52kb 65 31 disease disease NN cord-258230-s4ty52kb 65 32 vs. vs. FW cord-258230-s4ty52kb 65 33 non non NNS cord-258230-s4ty52kb 65 34 - - NNS cord-258230-s4ty52kb 65 35 users user NNS cord-258230-s4ty52kb 65 36 ( ( -LRB- cord-258230-s4ty52kb 65 37 OR or CC cord-258230-s4ty52kb 65 38 = = SYM cord-258230-s4ty52kb 65 39 0.81 0.81 CD cord-258230-s4ty52kb 65 40 , , , cord-258230-s4ty52kb 65 41 95 95 CD cord-258230-s4ty52kb 65 42 % % NN cord-258230-s4ty52kb 65 43 CI CI NNP cord-258230-s4ty52kb 65 44 0.41 0.41 CD cord-258230-s4ty52kb 65 45 - - SYM cord-258230-s4ty52kb 65 46 1.58 1.58 CD cord-258230-s4ty52kb 65 47 , , , cord-258230-s4ty52kb 65 48 I i NN cord-258230-s4ty52kb 65 49 2 2 CD cord-258230-s4ty52kb 65 50 = = SYM cord-258230-s4ty52kb 65 51 50.52 50.52 CD cord-258230-s4ty52kb 65 52 , , , cord-258230-s4ty52kb 65 53 P p NN cord-258230-s4ty52kb 65 54 - - HYPH cord-258230-s4ty52kb 65 55 value value NN cord-258230-s4ty52kb 65 56 = = SYM cord-258230-s4ty52kb 65 57 0.53 0.53 CD cord-258230-s4ty52kb 65 58 ) ) -RRB- cord-258230-s4ty52kb 66 1 ( ( -LRB- cord-258230-s4ty52kb 66 2 Figures figure NNS cord-258230-s4ty52kb 66 3 2 2 CD cord-258230-s4ty52kb 66 4 and and CC cord-258230-s4ty52kb 66 5 3 3 CD cord-258230-s4ty52kb 66 6 ) ) -RRB- cord-258230-s4ty52kb 66 7 . . . cord-258230-s4ty52kb 67 1 Similarly similarly RB cord-258230-s4ty52kb 67 2 , , , cord-258230-s4ty52kb 67 3 Reynolds Reynolds NNP cord-258230-s4ty52kb 67 4 et et NNP cord-258230-s4ty52kb 67 5 al al NNP cord-258230-s4ty52kb 67 6 . . . cord-258230-s4ty52kb 68 1 found find VBD cord-258230-s4ty52kb 68 2 a a DT cord-258230-s4ty52kb 68 3 slightly slightly RB cord-258230-s4ty52kb 68 4 lower low JJR cord-258230-s4ty52kb 68 5 rate rate NN cord-258230-s4ty52kb 68 6 of of IN cord-258230-s4ty52kb 68 7 severe severe JJ cord-258230-s4ty52kb 68 8 outcomes outcome NNS cord-258230-s4ty52kb 68 9 which which WDT cord-258230-s4ty52kb 68 10 included include VBD cord-258230-s4ty52kb 68 11 admission admission NN cord-258230-s4ty52kb 68 12 to to IN cord-258230-s4ty52kb 68 13 the the DT cord-258230-s4ty52kb 68 14 ICU ICU NNP cord-258230-s4ty52kb 68 15 , , , cord-258230-s4ty52kb 68 16 the the DT cord-258230-s4ty52kb 68 17 use use NN cord-258230-s4ty52kb 68 18 of of IN cord-258230-s4ty52kb 68 19 non non JJ cord-258230-s4ty52kb 68 20 - - JJ cord-258230-s4ty52kb 68 21 invasive invasive JJ cord-258230-s4ty52kb 68 22 or or CC cord-258230-s4ty52kb 68 23 invasive invasive JJ cord-258230-s4ty52kb 68 24 mechanical mechanical JJ cord-258230-s4ty52kb 68 25 ventilation ventilation NN cord-258230-s4ty52kb 68 26 , , , cord-258230-s4ty52kb 68 27 or or CC cord-258230-s4ty52kb 68 28 death death NN cord-258230-s4ty52kb 68 29 in in IN cord-258230-s4ty52kb 68 30 patients patient NNS cord-258230-s4ty52kb 68 31 on on IN cord-258230-s4ty52kb 68 32 an an DT cord-258230-s4ty52kb 68 33 ACEI ACEI NNP cord-258230-s4ty52kb 68 34 / / SYM cord-258230-s4ty52kb 68 35 ARB arb NN cord-258230-s4ty52kb 68 36 ( ( -LRB- cord-258230-s4ty52kb 68 37 24.8 24.8 CD cord-258230-s4ty52kb 68 38 % % NN cord-258230-s4ty52kb 68 39 ) ) -RRB- cord-258230-s4ty52kb 68 40 vs. vs. FW cord-258230-s4ty52kb 68 41 no no DT cord-258230-s4ty52kb 68 42 ACEI ACEI NNP cord-258230-s4ty52kb 68 43 / / SYM cord-258230-s4ty52kb 68 44 ARB ARB NNP cord-258230-s4ty52kb 68 45 ( ( -LRB- cord-258230-s4ty52kb 68 46 24.9 24.9 CD cord-258230-s4ty52kb 68 47 % % NN cord-258230-s4ty52kb 68 48 ) ) -RRB- cord-258230-s4ty52kb 68 49 14 14 CD cord-258230-s4ty52kb 68 50 , , , cord-258230-s4ty52kb 68 51 15 15 CD cord-258230-s4ty52kb 68 52 , , , cord-258230-s4ty52kb 68 53 [ [ -LRB- cord-258230-s4ty52kb 68 54 17 17 CD cord-258230-s4ty52kb 68 55 ] ] -RRB- cord-258230-s4ty52kb 68 56 [ [ -LRB- cord-258230-s4ty52kb 68 57 18 18 CD cord-258230-s4ty52kb 68 58 ] ] -RRB- cord-258230-s4ty52kb 68 59 [ [ -LRB- cord-258230-s4ty52kb 68 60 19 19 CD cord-258230-s4ty52kb 68 61 ] ] -RRB- cord-258230-s4ty52kb 68 62 21 21 CD cord-258230-s4ty52kb 68 63 , , , cord-258230-s4ty52kb 68 64 22 22 CD cord-258230-s4ty52kb 68 65 , , , cord-258230-s4ty52kb 68 66 [ [ -LRB- cord-258230-s4ty52kb 68 67 25 25 CD cord-258230-s4ty52kb 68 68 ] ] -RRB- cord-258230-s4ty52kb 68 69 [ [ -LRB- cord-258230-s4ty52kb 68 70 26 26 CD cord-258230-s4ty52kb 68 71 ] ] -RRB- cord-258230-s4ty52kb 68 72 [ [ -LRB- cord-258230-s4ty52kb 68 73 27 27 CD cord-258230-s4ty52kb 68 74 ] ] -RRB- cord-258230-s4ty52kb 68 75 [ [ -LRB- cord-258230-s4ty52kb 68 76 28 28 CD cord-258230-s4ty52kb 68 77 ] ] -RRB- cord-258230-s4ty52kb 68 78 [ [ -LRB- cord-258230-s4ty52kb 68 79 29 29 CD cord-258230-s4ty52kb 68 80 ] ] -RRB- cord-258230-s4ty52kb 69 1 ( ( -LRB- cord-258230-s4ty52kb 69 2 Table table NN cord-258230-s4ty52kb 69 3 2 2 CD cord-258230-s4ty52kb 69 4 ) ) -RRB- cord-258230-s4ty52kb 69 5 . . . cord-258230-s4ty52kb 70 1 On on IN cord-258230-s4ty52kb 70 2 the the DT cord-258230-s4ty52kb 70 3 contrary contrary NN cord-258230-s4ty52kb 70 4 , , , cord-258230-s4ty52kb 70 5 Guo Guo NNP cord-258230-s4ty52kb 70 6 Table Table NNP cord-258230-s4ty52kb 70 7 2 2 CD cord-258230-s4ty52kb 70 8 ) ) -RRB- cord-258230-s4ty52kb 70 9 . . . cord-258230-s4ty52kb 71 1 In in IN cord-258230-s4ty52kb 71 2 a a DT cord-258230-s4ty52kb 71 3 pooled pool VBN cord-258230-s4ty52kb 71 4 analysis analysis NN cord-258230-s4ty52kb 71 5 of of IN cord-258230-s4ty52kb 71 6 six six CD cord-258230-s4ty52kb 71 7 peer peer NN cord-258230-s4ty52kb 71 8 - - HYPH cord-258230-s4ty52kb 71 9 reviewed review VBN cord-258230-s4ty52kb 71 10 studies study NNS cord-258230-s4ty52kb 71 11 , , , cord-258230-s4ty52kb 71 12 there there EX cord-258230-s4ty52kb 71 13 was be VBD cord-258230-s4ty52kb 71 14 a a DT cord-258230-s4ty52kb 71 15 statistically statistically RB cord-258230-s4ty52kb 71 16 non non JJ cord-258230-s4ty52kb 71 17 - - JJ cord-258230-s4ty52kb 71 18 significant significant JJ cord-258230-s4ty52kb 71 19 association association NN cord-258230-s4ty52kb 71 20 of of IN cord-258230-s4ty52kb 71 21 ACEIs acei NNS cord-258230-s4ty52kb 71 22 / / SYM cord-258230-s4ty52kb 71 23 ARBs arb NNS cord-258230-s4ty52kb 71 24 with with IN cord-258230-s4ty52kb 71 25 lower low JJR cord-258230-s4ty52kb 71 26 odds odd NNS cord-258230-s4ty52kb 71 27 of of IN cord-258230-s4ty52kb 71 28 mortality mortality NN cord-258230-s4ty52kb 71 29 as as IN cord-258230-s4ty52kb 71 30 compared compare VBN cord-258230-s4ty52kb 71 31 with with IN cord-258230-s4ty52kb 71 32 non non NNS cord-258230-s4ty52kb 71 33 - - NNS cord-258230-s4ty52kb 71 34 users user NNS cord-258230-s4ty52kb 71 35 ( ( -LRB- cord-258230-s4ty52kb 71 36 OR or CC cord-258230-s4ty52kb 71 37 = = SYM cord-258230-s4ty52kb 71 38 0.86 0.86 CD cord-258230-s4ty52kb 71 39 , , , cord-258230-s4ty52kb 71 40 95 95 CD cord-258230-s4ty52kb 71 41 % % NN cord-258230-s4ty52kb 72 1 CI CI NNP cord-258230-s4ty52kb 72 2 = = NFP cord-258230-s4ty52kb 73 1 0.53 0.53 CD cord-258230-s4ty52kb 73 2 - - HYPH cord-258230-s4ty52kb 73 3 1.41 1.41 CD cord-258230-s4ty52kb 73 4 , , , cord-258230-s4ty52kb 73 5 I i NN cord-258230-s4ty52kb 73 6 2 2 CD cord-258230-s4ty52kb 73 7 = = SYM cord-258230-s4ty52kb 73 8 79.12 79.12 CD cord-258230-s4ty52kb 73 9 , , , cord-258230-s4ty52kb 73 10 P p NN cord-258230-s4ty52kb 73 11 - - HYPH cord-258230-s4ty52kb 73 12 value value NN cord-258230-s4ty52kb 73 13 = = SYM cord-258230-s4ty52kb 73 14 0.55 0.55 CD cord-258230-s4ty52kb 73 15 ) ) -RRB- cord-258230-s4ty52kb 74 1 ( ( -LRB- cord-258230-s4ty52kb 74 2 Figures figure NNS cord-258230-s4ty52kb 74 3 4 4 CD cord-258230-s4ty52kb 74 4 and and CC cord-258230-s4ty52kb 74 5 5 5 CD cord-258230-s4ty52kb 74 6 ) ) -RRB- cord-258230-s4ty52kb 75 1 The the DT cord-258230-s4ty52kb 75 2 sensitivity sensitivity NN cord-258230-s4ty52kb 75 3 of of IN cord-258230-s4ty52kb 75 4 the the DT cord-258230-s4ty52kb 75 5 pooled pool VBN cord-258230-s4ty52kb 75 6 results result NNS cord-258230-s4ty52kb 75 7 of of IN cord-258230-s4ty52kb 75 8 clinical clinical JJ cord-258230-s4ty52kb 75 9 severity severity NN cord-258230-s4ty52kb 75 10 and and CC cord-258230-s4ty52kb 75 11 mortality mortality NN cord-258230-s4ty52kb 75 12 outcomes outcome NNS cord-258230-s4ty52kb 75 13 to to IN cord-258230-s4ty52kb 75 14 the the DT cord-258230-s4ty52kb 75 15 removal removal NN cord-258230-s4ty52kb 75 16 of of IN cord-258230-s4ty52kb 75 17 each each DT cord-258230-s4ty52kb 75 18 study study NN cord-258230-s4ty52kb 75 19 is be VBZ cord-258230-s4ty52kb 75 20 reported report VBN cord-258230-s4ty52kb 75 21 in in IN cord-258230-s4ty52kb 75 22 Supplementary supplementary JJ cord-258230-s4ty52kb 75 23 material material NN cord-258230-s4ty52kb 75 24 online online RB cord-258230-s4ty52kb 75 25 , , , cord-258230-s4ty52kb 75 26 Figures figure VBZ cord-258230-s4ty52kb 75 27 S1-S4 S1-S4 NNP cord-258230-s4ty52kb 75 28 . . . cord-258230-s4ty52kb 76 1 Despite despite IN cord-258230-s4ty52kb 76 2 the the DT cord-258230-s4ty52kb 76 3 worldwide worldwide JJ cord-258230-s4ty52kb 76 4 implementation implementation NN cord-258230-s4ty52kb 76 5 of of IN cord-258230-s4ty52kb 76 6 public public JJ cord-258230-s4ty52kb 76 7 health health NN cord-258230-s4ty52kb 76 8 measures measure NNS cord-258230-s4ty52kb 76 9 such such JJ cord-258230-s4ty52kb 76 10 as as IN cord-258230-s4ty52kb 76 11 social social JJ cord-258230-s4ty52kb 76 12 distancing distancing NN cord-258230-s4ty52kb 76 13 , , , cord-258230-s4ty52kb 76 14 contact contact NN cord-258230-s4ty52kb 76 15 tracing tracing NN cord-258230-s4ty52kb 76 16 , , , cord-258230-s4ty52kb 76 17 and and CC cord-258230-s4ty52kb 76 18 mass mass JJ cord-258230-s4ty52kb 76 19 testing testing NN cord-258230-s4ty52kb 76 20 to to TO cord-258230-s4ty52kb 76 21 aid aid VB cord-258230-s4ty52kb 76 22 in in IN cord-258230-s4ty52kb 76 23 the the DT cord-258230-s4ty52kb 76 24 control control NN cord-258230-s4ty52kb 76 25 of of IN cord-258230-s4ty52kb 76 26 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 76 27 , , , cord-258230-s4ty52kb 76 28 the the DT cord-258230-s4ty52kb 76 29 global global JJ cord-258230-s4ty52kb 76 30 cases case NNS cord-258230-s4ty52kb 76 31 have have VBP cord-258230-s4ty52kb 76 32 risen rise VBN cord-258230-s4ty52kb 76 33 to to IN cord-258230-s4ty52kb 76 34 > > XX cord-258230-s4ty52kb 76 35 3 3 CD cord-258230-s4ty52kb 76 36 million million CD cord-258230-s4ty52kb 76 37 , , , cord-258230-s4ty52kb 76 38 and and CC cord-258230-s4ty52kb 76 39 > > XX cord-258230-s4ty52kb 76 40 200 200 CD cord-258230-s4ty52kb 76 41 000 000 CD cord-258230-s4ty52kb 76 42 patients patient NNS cord-258230-s4ty52kb 76 43 had have VBD cord-258230-s4ty52kb 76 44 lost lose VBN cord-258230-s4ty52kb 76 45 their -PRON- PRP$ cord-258230-s4ty52kb 76 46 lives life NNS cord-258230-s4ty52kb 76 47 by by IN cord-258230-s4ty52kb 76 48 27 27 CD cord-258230-s4ty52kb 76 49 April April NNP cord-258230-s4ty52kb 76 50 2020 2020 CD cord-258230-s4ty52kb 76 51 , , , cord-258230-s4ty52kb 76 52 2,31 2,31 CD cord-258230-s4ty52kb 76 53 which which WDT cord-258230-s4ty52kb 76 54 further further RB cord-258230-s4ty52kb 76 55 requires require VBZ cord-258230-s4ty52kb 76 56 attention attention NN cord-258230-s4ty52kb 76 57 . . . cord-258230-s4ty52kb 77 1 Several several JJ cord-258230-s4ty52kb 77 2 studies study NNS cord-258230-s4ty52kb 77 3 have have VBP cord-258230-s4ty52kb 77 4 reported report VBN cord-258230-s4ty52kb 77 5 increased increase VBN cord-258230-s4ty52kb 77 6 rates rate NNS cord-258230-s4ty52kb 77 7 of of IN cord-258230-s4ty52kb 77 8 COVID-19-associated covid-19-associated JJ cord-258230-s4ty52kb 77 9 mortality mortality NN cord-258230-s4ty52kb 77 10 in in IN cord-258230-s4ty52kb 77 11 patients patient NNS cord-258230-s4ty52kb 77 12 with with IN cord-258230-s4ty52kb 77 13 significant significant JJ cord-258230-s4ty52kb 77 14 comorbidities comorbiditie NNS cord-258230-s4ty52kb 77 15 such such JJ cord-258230-s4ty52kb 77 16 as as IN cord-258230-s4ty52kb 77 17 hypertension hypertension NN cord-258230-s4ty52kb 77 18 , , , cord-258230-s4ty52kb 77 19 cardiovascular cardiovascular JJ cord-258230-s4ty52kb 77 20 disease disease NN cord-258230-s4ty52kb 77 21 , , , cord-258230-s4ty52kb 77 22 chronic chronic JJ cord-258230-s4ty52kb 77 23 kidney kidney NN cord-258230-s4ty52kb 77 24 disease disease NN cord-258230-s4ty52kb 77 25 , , , cord-258230-s4ty52kb 77 26 or or CC cord-258230-s4ty52kb 77 27 heart heart NN cord-258230-s4ty52kb 77 28 failure failure NN cord-258230-s4ty52kb 77 29 . . . cord-258230-s4ty52kb 78 1 3 3 CD cord-258230-s4ty52kb 78 2 , , , cord-258230-s4ty52kb 78 3 4 4 CD cord-258230-s4ty52kb 79 1 Although although IN cord-258230-s4ty52kb 79 2 ACEIs acei NNS cord-258230-s4ty52kb 79 3 and and CC cord-258230-s4ty52kb 79 4 ARBs arb NNS cord-258230-s4ty52kb 79 5 are be VBP cord-258230-s4ty52kb 79 6 commonly commonly RB cord-258230-s4ty52kb 79 7 prescribed prescribe VBN cord-258230-s4ty52kb 79 8 to to TO cord-258230-s4ty52kb 79 9 treat treat VB cord-258230-s4ty52kb 79 10 some some DT cord-258230-s4ty52kb 79 11 of of IN cord-258230-s4ty52kb 79 12 these these DT cord-258230-s4ty52kb 79 13 comorbidities comorbiditie NNS cord-258230-s4ty52kb 79 14 , , , cord-258230-s4ty52kb 79 15 the the DT cord-258230-s4ty52kb 79 16 fact fact NN cord-258230-s4ty52kb 79 17 that that IN cord-258230-s4ty52kb 79 18 the the DT cord-258230-s4ty52kb 79 19 ACE2 ACE2 NNP cord-258230-s4ty52kb 79 20 receptor receptor NN cord-258230-s4ty52kb 79 21 is be VBZ cord-258230-s4ty52kb 79 22 the the DT cord-258230-s4ty52kb 79 23 main main JJ cord-258230-s4ty52kb 79 24 binding binding NN cord-258230-s4ty52kb 79 25 site site NN cord-258230-s4ty52kb 79 26 for for IN cord-258230-s4ty52kb 79 27 entry entry NN cord-258230-s4ty52kb 79 28 of of IN cord-258230-s4ty52kb 79 29 SARS SARS NNP cord-258230-s4ty52kb 79 30 - - HYPH cord-258230-s4ty52kb 79 31 CoV-2 CoV-2 NNP cord-258230-s4ty52kb 79 32 caused cause VBD cord-258230-s4ty52kb 79 33 concerns concern NNS cord-258230-s4ty52kb 79 34 regarding regard VBG cord-258230-s4ty52kb 79 35 the the DT cord-258230-s4ty52kb 79 36 use use NN cord-258230-s4ty52kb 79 37 of of IN cord-258230-s4ty52kb 79 38 ACEIs acei NNS cord-258230-s4ty52kb 79 39 and and CC cord-258230-s4ty52kb 79 40 ARBs arb NNS cord-258230-s4ty52kb 79 41 in in IN cord-258230-s4ty52kb 79 42 such such JJ cord-258230-s4ty52kb 79 43 patients patient NNS cord-258230-s4ty52kb 79 44 . . . cord-258230-s4ty52kb 80 1 5 5 LS cord-258230-s4ty52kb 81 1 , , , cord-258230-s4ty52kb 81 2 32 32 CD cord-258230-s4ty52kb 81 3 Several several JJ cord-258230-s4ty52kb 81 4 evidence evidence NN cord-258230-s4ty52kb 81 5 - - HYPH cord-258230-s4ty52kb 81 6 based base VBN cord-258230-s4ty52kb 81 7 consensus consensus NN cord-258230-s4ty52kb 81 8 and and CC cord-258230-s4ty52kb 81 9 position position NN cord-258230-s4ty52kb 81 10 statements statement NNS cord-258230-s4ty52kb 81 11 were be VBD cord-258230-s4ty52kb 81 12 formulated formulate VBN cord-258230-s4ty52kb 81 13 by by IN cord-258230-s4ty52kb 81 14 various various JJ cord-258230-s4ty52kb 81 15 cardiovascular cardiovascular NN cord-258230-s4ty52kb 81 16 and and CC cord-258230-s4ty52kb 81 17 hypertension hypertension NN cord-258230-s4ty52kb 81 18 societies society NNS cord-258230-s4ty52kb 81 19 which which WDT cord-258230-s4ty52kb 81 20 recommended recommend VBD cord-258230-s4ty52kb 81 21 continued continued JJ cord-258230-s4ty52kb 81 22 use use NN cord-258230-s4ty52kb 81 23 of of IN cord-258230-s4ty52kb 81 24 ACEIs acei NNS cord-258230-s4ty52kb 81 25 and and CC cord-258230-s4ty52kb 81 26 ARBs arb NNS cord-258230-s4ty52kb 81 27 in in IN cord-258230-s4ty52kb 81 28 COVID-19 covid-19 CD cord-258230-s4ty52kb 81 29 patients patient NNS cord-258230-s4ty52kb 81 30 , , , cord-258230-s4ty52kb 81 31 citing cite VBG cord-258230-s4ty52kb 81 32 the the DT cord-258230-s4ty52kb 81 33 lack lack NN cord-258230-s4ty52kb 81 34 of of IN cord-258230-s4ty52kb 81 35 any any DT cord-258230-s4ty52kb 81 36 contrary contrary JJ cord-258230-s4ty52kb 81 37 clinical clinical JJ cord-258230-s4ty52kb 81 38 evidence evidence NN cord-258230-s4ty52kb 81 39 . . . cord-258230-s4ty52kb 82 1 [ [ -LRB- cord-258230-s4ty52kb 82 2 8 8 CD cord-258230-s4ty52kb 82 3 ] ] -RRB- cord-258230-s4ty52kb 82 4 [ [ -LRB- cord-258230-s4ty52kb 82 5 9 9 CD cord-258230-s4ty52kb 82 6 ] ] -RRB- cord-258230-s4ty52kb 82 7 [ [ -LRB- cord-258230-s4ty52kb 82 8 10 10 CD cord-258230-s4ty52kb 82 9 ] ] -RRB- cord-258230-s4ty52kb 82 10 [ [ -LRB- cord-258230-s4ty52kb 82 11 11 11 CD cord-258230-s4ty52kb 82 12 ] ] -RRB- cord-258230-s4ty52kb 83 1 [ [ -LRB- cord-258230-s4ty52kb 83 2 12 12 CD cord-258230-s4ty52kb 83 3 ] ] -RRB- cord-258230-s4ty52kb 84 1 Since since IN cord-258230-s4ty52kb 84 2 then then RB cord-258230-s4ty52kb 84 3 , , , cord-258230-s4ty52kb 84 4 however however RB cord-258230-s4ty52kb 84 5 , , , cord-258230-s4ty52kb 84 6 several several JJ cord-258230-s4ty52kb 84 7 clinical clinical JJ cord-258230-s4ty52kb 84 8 studies study NNS cord-258230-s4ty52kb 84 9 have have VBP cord-258230-s4ty52kb 84 10 evaluated evaluate VBN cord-258230-s4ty52kb 84 11 the the DT cord-258230-s4ty52kb 84 12 association association NN cord-258230-s4ty52kb 84 13 of of IN cord-258230-s4ty52kb 84 14 ACEIs ACEIs NNPS cord-258230-s4ty52kb 84 15 and and CC cord-258230-s4ty52kb 84 16 ARBs arb NNS cord-258230-s4ty52kb 84 17 in in IN cord-258230-s4ty52kb 84 18 COVID-19 covid-19 CD cord-258230-s4ty52kb 84 19 patients patient NNS cord-258230-s4ty52kb 84 20 and and CC cord-258230-s4ty52kb 84 21 comorbidities comorbiditie NNS cord-258230-s4ty52kb 84 22 . . . cord-258230-s4ty52kb 85 1 It -PRON- PRP cord-258230-s4ty52kb 85 2 is be VBZ cord-258230-s4ty52kb 85 3 imperative imperative JJ cord-258230-s4ty52kb 85 4 to to TO cord-258230-s4ty52kb 85 5 accurately accurately RB cord-258230-s4ty52kb 85 6 predict predict VB cord-258230-s4ty52kb 85 7 clinical clinical JJ cord-258230-s4ty52kb 85 8 outcomes outcome NNS cord-258230-s4ty52kb 85 9 of of IN cord-258230-s4ty52kb 85 10 COVID-19 covid-19 JJ cord-258230-s4ty52kb 85 11 patients patient NNS cord-258230-s4ty52kb 85 12 , , , cord-258230-s4ty52kb 85 13 especially especially RB cord-258230-s4ty52kb 85 14 those those DT cord-258230-s4ty52kb 85 15 with with IN cord-258230-s4ty52kb 85 16 comorbidities comorbiditie NNS cord-258230-s4ty52kb 85 17 and and CC cord-258230-s4ty52kb 85 18 taking take VBG cord-258230-s4ty52kb 85 19 an an DT cord-258230-s4ty52kb 85 20 ACEI ACEI NNP cord-258230-s4ty52kb 85 21 or or CC cord-258230-s4ty52kb 85 22 ARB ARB NNP cord-258230-s4ty52kb 85 23 , , , cord-258230-s4ty52kb 85 24 to to TO cord-258230-s4ty52kb 85 25 decide decide VB cord-258230-s4ty52kb 85 26 whether whether IN cord-258230-s4ty52kb 85 27 to to TO cord-258230-s4ty52kb 85 28 continue continue VB cord-258230-s4ty52kb 85 29 or or CC cord-258230-s4ty52kb 85 30 switch switch VB cord-258230-s4ty52kb 85 31 to to IN cord-258230-s4ty52kb 85 32 another another DT cord-258230-s4ty52kb 85 33 medication medication NN cord-258230-s4ty52kb 85 34 . . . cord-258230-s4ty52kb 86 1 However however RB cord-258230-s4ty52kb 86 2 , , , cord-258230-s4ty52kb 86 3 there there EX cord-258230-s4ty52kb 86 4 were be VBD cord-258230-s4ty52kb 86 5 conflicting conflict VBG cord-258230-s4ty52kb 86 6 findings finding NNS cord-258230-s4ty52kb 86 7 reported report VBN cord-258230-s4ty52kb 86 8 in in IN cord-258230-s4ty52kb 86 9 several several JJ cord-258230-s4ty52kb 86 10 studies study NNS cord-258230-s4ty52kb 86 11 , , , cord-258230-s4ty52kb 86 12 as as IN cord-258230-s4ty52kb 86 13 Meng Meng NNP cord-258230-s4ty52kb 86 14 ( ( -LRB- cord-258230-s4ty52kb 86 15 Figures figure NNS cord-258230-s4ty52kb 86 16 2 2 CD cord-258230-s4ty52kb 86 17 and and CC cord-258230-s4ty52kb 86 18 3 3 CD cord-258230-s4ty52kb 86 19 ) ) -RRB- cord-258230-s4ty52kb 86 20 . . . cord-258230-s4ty52kb 87 1 ACEI ACEI NNP cord-258230-s4ty52kb 87 2 and and CC cord-258230-s4ty52kb 87 3 ARB ARB NNP cord-258230-s4ty52kb 87 4 use use NN cord-258230-s4ty52kb 87 5 in in IN cord-258230-s4ty52kb 87 6 COVID-19 covid-19 JJ cord-258230-s4ty52kb 87 7 patients patient NNS cord-258230-s4ty52kb 87 8 mortality mortality NN cord-258230-s4ty52kb 87 9 outcomes outcome NNS cord-258230-s4ty52kb 87 10 , , , cord-258230-s4ty52kb 87 11 strengthening strengthen VBG cord-258230-s4ty52kb 87 12 their -PRON- PRP$ cord-258230-s4ty52kb 87 13 conclusions conclusion NNS cord-258230-s4ty52kb 87 14 regarding regard VBG cord-258230-s4ty52kb 87 15 safety safety NN cord-258230-s4ty52kb 87 16 of of IN cord-258230-s4ty52kb 87 17 ACEI ACEI NNP cord-258230-s4ty52kb 87 18 / / SYM cord-258230-s4ty52kb 87 19 ARB ARB NNP cord-258230-s4ty52kb 87 20 use use NN cord-258230-s4ty52kb 87 21 ; ; : cord-258230-s4ty52kb 87 22 however however RB cord-258230-s4ty52kb 87 23 , , , cord-258230-s4ty52kb 87 24 a a DT cord-258230-s4ty52kb 87 25 large large JJ cord-258230-s4ty52kb 87 26 sample sample NN cord-258230-s4ty52kb 87 27 size size NN cord-258230-s4ty52kb 87 28 study study NN cord-258230-s4ty52kb 87 29 conducted conduct VBN cord-258230-s4ty52kb 87 30 in in IN cord-258230-s4ty52kb 87 31 New New NNP cord-258230-s4ty52kb 87 32 York York NNP cord-258230-s4ty52kb 87 33 in in IN cord-258230-s4ty52kb 87 34 > > XX cord-258230-s4ty52kb 87 35 1000 1000 CD cord-258230-s4ty52kb 87 36 COVID-19 covid-19 CD cord-258230-s4ty52kb 87 37 patients patient NNS cord-258230-s4ty52kb 87 38 by by IN cord-258230-s4ty52kb 87 39 Richardson Richardson NNP cord-258230-s4ty52kb 87 40 et et NNP cord-258230-s4ty52kb 87 41 al al NNP cord-258230-s4ty52kb 87 42 . . . cord-258230-s4ty52kb 88 1 raised raise VBN cord-258230-s4ty52kb 88 2 concerns concern NNS cord-258230-s4ty52kb 88 3 of of IN cord-258230-s4ty52kb 88 4 worse bad JJR cord-258230-s4ty52kb 88 5 mortality mortality NN cord-258230-s4ty52kb 88 6 outcomes outcome NNS cord-258230-s4ty52kb 88 7 with with IN cord-258230-s4ty52kb 88 8 ACEI ACEI NNP cord-258230-s4ty52kb 88 9 / / SYM cord-258230-s4ty52kb 88 10 ARB ARB NNP cord-258230-s4ty52kb 88 11 use use NN cord-258230-s4ty52kb 88 12 and and CC cord-258230-s4ty52kb 88 13 can can MD cord-258230-s4ty52kb 88 14 not not RB cord-258230-s4ty52kb 88 15 be be VB cord-258230-s4ty52kb 88 16 overlooked overlook VBN cord-258230-s4ty52kb 88 17 . . . cord-258230-s4ty52kb 89 1 15 15 CD cord-258230-s4ty52kb 89 2 , , , cord-258230-s4ty52kb 89 3 21 21 CD cord-258230-s4ty52kb 90 1 In in IN cord-258230-s4ty52kb 90 2 a a DT cord-258230-s4ty52kb 90 3 pooled pool VBN cord-258230-s4ty52kb 90 4 analysis analysis NN cord-258230-s4ty52kb 90 5 of of IN cord-258230-s4ty52kb 90 6 six six CD cord-258230-s4ty52kb 90 7 peer peer NN cord-258230-s4ty52kb 90 8 - - HYPH cord-258230-s4ty52kb 90 9 reviewed review VBN cord-258230-s4ty52kb 90 10 studies study NNS cord-258230-s4ty52kb 90 11 , , , cord-258230-s4ty52kb 90 12 there there EX cord-258230-s4ty52kb 90 13 was be VBD cord-258230-s4ty52kb 90 14 a a DT cord-258230-s4ty52kb 90 15 statistically statistically RB cord-258230-s4ty52kb 90 16 non non JJ cord-258230-s4ty52kb 90 17 - - JJ cord-258230-s4ty52kb 90 18 significant significant JJ cord-258230-s4ty52kb 90 19 association association NN cord-258230-s4ty52kb 90 20 of of IN cord-258230-s4ty52kb 90 21 ACEI/ ACEI/ NNP cord-258230-s4ty52kb 90 22 ARB ARB NNP cord-258230-s4ty52kb 90 23 use use NN cord-258230-s4ty52kb 90 24 with with IN cord-258230-s4ty52kb 90 25 lower low JJR cord-258230-s4ty52kb 90 26 odds odd NNS cord-258230-s4ty52kb 90 27 of of IN cord-258230-s4ty52kb 90 28 mortality mortality NN cord-258230-s4ty52kb 90 29 as as IN cord-258230-s4ty52kb 90 30 compared compare VBN cord-258230-s4ty52kb 90 31 with with IN cord-258230-s4ty52kb 90 32 non non NNS cord-258230-s4ty52kb 90 33 - - NNS cord-258230-s4ty52kb 90 34 users user NNS cord-258230-s4ty52kb 90 35 ( ( -LRB- cord-258230-s4ty52kb 90 36 OR or CC cord-258230-s4ty52kb 90 37 = = SYM cord-258230-s4ty52kb 90 38 0.86 0.86 CD cord-258230-s4ty52kb 90 39 , , , cord-258230-s4ty52kb 90 40 95 95 CD cord-258230-s4ty52kb 90 41 % % NN cord-258230-s4ty52kb 91 1 CI CI NNP cord-258230-s4ty52kb 91 2 = = NFP cord-258230-s4ty52kb 92 1 0.53 0.53 CD cord-258230-s4ty52kb 92 2 - - HYPH cord-258230-s4ty52kb 92 3 1.41 1.41 CD cord-258230-s4ty52kb 92 4 , , , cord-258230-s4ty52kb 92 5 I i NN cord-258230-s4ty52kb 92 6 2 2 CD cord-258230-s4ty52kb 92 7 = = SYM cord-258230-s4ty52kb 92 8 79.12 79.12 CD cord-258230-s4ty52kb 92 9 , , , cord-258230-s4ty52kb 92 10 P p NN cord-258230-s4ty52kb 92 11 - - HYPH cord-258230-s4ty52kb 92 12 value value NN cord-258230-s4ty52kb 92 13 = = SYM cord-258230-s4ty52kb 92 14 0.55 0.55 CD cord-258230-s4ty52kb 92 15 ) ) -RRB- cord-258230-s4ty52kb 93 1 ( ( -LRB- cord-258230-s4ty52kb 93 2 Figures figure NNS cord-258230-s4ty52kb 93 3 4 4 CD cord-258230-s4ty52kb 93 4 _SP cord-258230-s4ty52kb 93 5 and and CC cord-258230-s4ty52kb 93 6 5 5 CD cord-258230-s4ty52kb 93 7 ) ) -RRB- cord-258230-s4ty52kb 93 8 . . . cord-258230-s4ty52kb 94 1 Several several JJ cord-258230-s4ty52kb 94 2 hypotheses hypothesis NNS cord-258230-s4ty52kb 94 3 have have VBP cord-258230-s4ty52kb 94 4 been be VBN cord-258230-s4ty52kb 94 5 put put VBN cord-258230-s4ty52kb 94 6 forward forward RB cord-258230-s4ty52kb 94 7 explaining explain VBG cord-258230-s4ty52kb 94 8 the the DT cord-258230-s4ty52kb 94 9 positive positive JJ cord-258230-s4ty52kb 94 10 and and CC cord-258230-s4ty52kb 94 11 negative negative JJ cord-258230-s4ty52kb 94 12 aspects aspect NNS cord-258230-s4ty52kb 94 13 of of IN cord-258230-s4ty52kb 94 14 ACEI ACEI NNP cord-258230-s4ty52kb 94 15 / / SYM cord-258230-s4ty52kb 94 16 ARB ARB NNP cord-258230-s4ty52kb 94 17 administration administration NN cord-258230-s4ty52kb 94 18 in in IN cord-258230-s4ty52kb 94 19 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 94 20 patients patient NNS cord-258230-s4ty52kb 94 21 . . . cord-258230-s4ty52kb 95 1 Positive positive JJ cord-258230-s4ty52kb 95 2 effects effect NNS cord-258230-s4ty52kb 95 3 include include VBP cord-258230-s4ty52kb 95 4 ACE2 ACE2 NNP cord-258230-s4ty52kb 95 5 receptor receptor NN cord-258230-s4ty52kb 95 6 blockade blockade NN cord-258230-s4ty52kb 95 7 , , , cord-258230-s4ty52kb 95 8 disabling disable VBG cord-258230-s4ty52kb 95 9 viral viral JJ cord-258230-s4ty52kb 95 10 entry entry NN cord-258230-s4ty52kb 95 11 into into IN cord-258230-s4ty52kb 95 12 the the DT cord-258230-s4ty52kb 95 13 heart heart NN cord-258230-s4ty52kb 95 14 and and CC cord-258230-s4ty52kb 95 15 lungs lung NNS cord-258230-s4ty52kb 95 16 , , , cord-258230-s4ty52kb 95 17 and and CC cord-258230-s4ty52kb 95 18 an an DT cord-258230-s4ty52kb 95 19 overall overall JJ cord-258230-s4ty52kb 95 20 decrease decrease NN cord-258230-s4ty52kb 95 21 in in IN cord-258230-s4ty52kb 95 22 inflammation inflammation NN cord-258230-s4ty52kb 95 23 secondary secondary JJ cord-258230-s4ty52kb 95 24 to to IN cord-258230-s4ty52kb 95 25 ACEIs acei NNS cord-258230-s4ty52kb 95 26 / / SYM cord-258230-s4ty52kb 95 27 ARBs arb NNS cord-258230-s4ty52kb 95 28 , , , cord-258230-s4ty52kb 95 29 suggesting suggest VBG cord-258230-s4ty52kb 95 30 that that IN cord-258230-s4ty52kb 95 31 the the DT cord-258230-s4ty52kb 95 32 use use NN cord-258230-s4ty52kb 95 33 of of IN cord-258230-s4ty52kb 95 34 an an DT cord-258230-s4ty52kb 95 35 ACEI ACEI NNP cord-258230-s4ty52kb 95 36 might may MD cord-258230-s4ty52kb 95 37 be be VB cord-258230-s4ty52kb 95 38 protective protective JJ cord-258230-s4ty52kb 95 39 against against IN cord-258230-s4ty52kb 95 40 respiratory respiratory JJ cord-258230-s4ty52kb 95 41 complications complication NNS cord-258230-s4ty52kb 95 42 . . . cord-258230-s4ty52kb 96 1 Negative negative JJ cord-258230-s4ty52kb 96 2 effects effect NNS cord-258230-s4ty52kb 96 3 include include VBP cord-258230-s4ty52kb 96 4 a a DT cord-258230-s4ty52kb 96 5 possible possible JJ cord-258230-s4ty52kb 96 6 retrograde retrograde JJ cord-258230-s4ty52kb 96 7 feedback feedback NN cord-258230-s4ty52kb 96 8 mechanism mechanism NN cord-258230-s4ty52kb 96 9 , , , cord-258230-s4ty52kb 96 10 by by IN cord-258230-s4ty52kb 96 11 which which WDT cord-258230-s4ty52kb 96 12 ACE2 ACE2 NNP cord-258230-s4ty52kb 96 13 receptors receptor NNS cord-258230-s4ty52kb 96 14 are be VBP cord-258230-s4ty52kb 96 15 up up RB cord-258230-s4ty52kb 96 16 - - HYPH cord-258230-s4ty52kb 96 17 regulated regulate VBN cord-258230-s4ty52kb 96 18 , , , cord-258230-s4ty52kb 96 19 which which WDT cord-258230-s4ty52kb 96 20 may may MD cord-258230-s4ty52kb 96 21 lead lead VB cord-258230-s4ty52kb 96 22 to to IN cord-258230-s4ty52kb 96 23 severe severe JJ cord-258230-s4ty52kb 96 24 pneumonia pneumonia NN cord-258230-s4ty52kb 96 25 , , , cord-258230-s4ty52kb 96 26 increasing increase VBG cord-258230-s4ty52kb 96 27 the the DT cord-258230-s4ty52kb 96 28 risk risk NN cord-258230-s4ty52kb 96 29 of of IN cord-258230-s4ty52kb 96 30 severe severe JJ cord-258230-s4ty52kb 96 31 outcomes outcome NNS cord-258230-s4ty52kb 96 32 and and CC cord-258230-s4ty52kb 96 33 mortality mortality NN cord-258230-s4ty52kb 96 34 . . . cord-258230-s4ty52kb 97 1 33 33 CD cord-258230-s4ty52kb 97 2 Individuals individual NNS cord-258230-s4ty52kb 97 3 with with IN cord-258230-s4ty52kb 97 4 ACE2 ACE2 NNP cord-258230-s4ty52kb 97 5 polymorphisms polymorphism NNS cord-258230-s4ty52kb 97 6 have have VBP cord-258230-s4ty52kb 97 7 an an DT cord-258230-s4ty52kb 97 8 increased increase VBN cord-258230-s4ty52kb 97 9 genetic genetic JJ cord-258230-s4ty52kb 97 10 predisposition predisposition NN cord-258230-s4ty52kb 97 11 for for IN cord-258230-s4ty52kb 97 12 an an DT cord-258230-s4ty52kb 97 13 increased increase VBN cord-258230-s4ty52kb 97 14 risk risk NN cord-258230-s4ty52kb 97 15 of of IN cord-258230-s4ty52kb 97 16 SARS SARS NNP cord-258230-s4ty52kb 97 17 - - HYPH cord-258230-s4ty52kb 97 18 CoV-2 CoV-2 NNP cord-258230-s4ty52kb 97 19 infection infection NN cord-258230-s4ty52kb 97 20 and and CC cord-258230-s4ty52kb 97 21 may may MD cord-258230-s4ty52kb 97 22 have have VB cord-258230-s4ty52kb 97 23 harmful harmful JJ cord-258230-s4ty52kb 97 24 effects effect NNS cord-258230-s4ty52kb 97 25 of of IN cord-258230-s4ty52kb 97 26 ACEIs acei NNS cord-258230-s4ty52kb 97 27 / / SYM cord-258230-s4ty52kb 97 28 ARBs arb NNS cord-258230-s4ty52kb 97 29 . . . cord-258230-s4ty52kb 98 1 34 34 CD cord-258230-s4ty52kb 99 1 This this DT cord-258230-s4ty52kb 99 2 aspect aspect NN cord-258230-s4ty52kb 99 3 is be VBZ cord-258230-s4ty52kb 99 4 worth worth JJ cord-258230-s4ty52kb 99 5 considering consider VBG cord-258230-s4ty52kb 99 6 and and CC cord-258230-s4ty52kb 99 7 needs need VBZ cord-258230-s4ty52kb 99 8 to to TO cord-258230-s4ty52kb 99 9 be be VB cord-258230-s4ty52kb 99 10 evaluated evaluate VBN cord-258230-s4ty52kb 99 11 in in IN cord-258230-s4ty52kb 99 12 future future JJ cord-258230-s4ty52kb 99 13 studies study NNS cord-258230-s4ty52kb 99 14 . . . cord-258230-s4ty52kb 100 1 To to IN cord-258230-s4ty52kb 100 2 the the DT cord-258230-s4ty52kb 100 3 best good JJS cord-258230-s4ty52kb 100 4 of of IN cord-258230-s4ty52kb 100 5 our -PRON- PRP$ cord-258230-s4ty52kb 100 6 knowledge knowledge NN cord-258230-s4ty52kb 100 7 , , , cord-258230-s4ty52kb 100 8 this this DT cord-258230-s4ty52kb 100 9 systematic systematic JJ cord-258230-s4ty52kb 100 10 review review NN cord-258230-s4ty52kb 100 11 is be VBZ cord-258230-s4ty52kb 100 12 a a DT cord-258230-s4ty52kb 100 13 comprehensive comprehensive JJ cord-258230-s4ty52kb 100 14 exploration exploration NN cord-258230-s4ty52kb 100 15 and and CC cord-258230-s4ty52kb 100 16 analysis analysis NN cord-258230-s4ty52kb 100 17 of of IN cord-258230-s4ty52kb 100 18 existing exist VBG cord-258230-s4ty52kb 100 19 literature literature NN cord-258230-s4ty52kb 100 20 in in IN cord-258230-s4ty52kb 100 21 this this DT cord-258230-s4ty52kb 100 22 topic topic NN cord-258230-s4ty52kb 100 23 to to IN cord-258230-s4ty52kb 100 24 date date NN cord-258230-s4ty52kb 100 25 . . . cord-258230-s4ty52kb 101 1 Our -PRON- PRP$ cord-258230-s4ty52kb 101 2 review review NN cord-258230-s4ty52kb 101 3 has have VBZ cord-258230-s4ty52kb 101 4 limitations limitation NNS cord-258230-s4ty52kb 101 5 in in IN cord-258230-s4ty52kb 101 6 its -PRON- PRP$ cord-258230-s4ty52kb 101 7 rigour rigour NN cord-258230-s4ty52kb 101 8 due due IN cord-258230-s4ty52kb 101 9 to to IN cord-258230-s4ty52kb 101 10 the the DT cord-258230-s4ty52kb 101 11 scarce scarce JJ cord-258230-s4ty52kb 101 12 existing exist VBG cord-258230-s4ty52kb 101 13 data datum NNS cord-258230-s4ty52kb 101 14 and and CC cord-258230-s4ty52kb 101 15 diverse diverse JJ cord-258230-s4ty52kb 101 16 study study NN cord-258230-s4ty52kb 101 17 types type NNS cord-258230-s4ty52kb 101 18 available available JJ cord-258230-s4ty52kb 101 19 . . . cord-258230-s4ty52kb 102 1 The the DT cord-258230-s4ty52kb 102 2 rapidly rapidly RB cord-258230-s4ty52kb 102 3 emerging emerge VBG cord-258230-s4ty52kb 102 4 knowledge knowledge NN cord-258230-s4ty52kb 102 5 base base NN cord-258230-s4ty52kb 102 6 of of IN cord-258230-s4ty52kb 102 7 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 102 8 presents present VBZ cord-258230-s4ty52kb 102 9 the the DT cord-258230-s4ty52kb 102 10 possibility possibility NN cord-258230-s4ty52kb 102 11 that that IN cord-258230-s4ty52kb 102 12 a a DT cord-258230-s4ty52kb 102 13 few few JJ cord-258230-s4ty52kb 102 14 studies study NNS cord-258230-s4ty52kb 102 15 ( ( -LRB- cord-258230-s4ty52kb 102 16 particularly particularly RB cord-258230-s4ty52kb 102 17 unpublished unpublished JJ cord-258230-s4ty52kb 102 18 / / SYM cord-258230-s4ty52kb 102 19 under under IN cord-258230-s4ty52kb 102 20 peer peer NN cord-258230-s4ty52kb 102 21 review review NN cord-258230-s4ty52kb 102 22 ) ) -RRB- cord-258230-s4ty52kb 102 23 remain remain VBP cord-258230-s4ty52kb 102 24 uncaptured uncaptured JJ cord-258230-s4ty52kb 102 25 . . . cord-258230-s4ty52kb 103 1 However however RB cord-258230-s4ty52kb 103 2 , , , cord-258230-s4ty52kb 103 3 we -PRON- PRP cord-258230-s4ty52kb 103 4 have have VBP cord-258230-s4ty52kb 103 5 tried try VBN cord-258230-s4ty52kb 103 6 our -PRON- PRP$ cord-258230-s4ty52kb 103 7 best good JJS cord-258230-s4ty52kb 103 8 to to TO cord-258230-s4ty52kb 103 9 mitigate mitigate VB cord-258230-s4ty52kb 103 10 this this DT cord-258230-s4ty52kb 103 11 by by IN cord-258230-s4ty52kb 103 12 allowing allow VBG cord-258230-s4ty52kb 103 13 broad broad JJ cord-258230-s4ty52kb 103 14 search search NN cord-258230-s4ty52kb 103 15 terms term NNS cord-258230-s4ty52kb 103 16 and and CC cord-258230-s4ty52kb 103 17 by by IN cord-258230-s4ty52kb 103 18 including include VBG cord-258230-s4ty52kb 103 19 many many JJ cord-258230-s4ty52kb 103 20 databases database NNS cord-258230-s4ty52kb 103 21 and and CC cord-258230-s4ty52kb 103 22 repositories repository NNS cord-258230-s4ty52kb 103 23 . . . cord-258230-s4ty52kb 104 1 We -PRON- PRP cord-258230-s4ty52kb 104 2 have have VBP cord-258230-s4ty52kb 104 3 also also RB cord-258230-s4ty52kb 104 4 tried try VBN cord-258230-s4ty52kb 104 5 to to TO cord-258230-s4ty52kb 104 6 comprehensively comprehensively RB cord-258230-s4ty52kb 104 7 review review VB cord-258230-s4ty52kb 104 8 and and CC cord-258230-s4ty52kb 104 9 analyse analyse VB cord-258230-s4ty52kb 104 10 the the DT cord-258230-s4ty52kb 104 11 existing exist VBG cord-258230-s4ty52kb 104 12 data datum NNS cord-258230-s4ty52kb 104 13 . . . cord-258230-s4ty52kb 105 1 Considering consider VBG cord-258230-s4ty52kb 105 2 the the DT cord-258230-s4ty52kb 105 3 inconsistent inconsistent JJ cord-258230-s4ty52kb 105 4 clinical clinical JJ cord-258230-s4ty52kb 105 5 studies study NNS cord-258230-s4ty52kb 105 6 and and CC cord-258230-s4ty52kb 105 7 conflicting conflict VBG cord-258230-s4ty52kb 105 8 hypotheses hypothesis NNS cord-258230-s4ty52kb 105 9 , , , cord-258230-s4ty52kb 105 10 it -PRON- PRP cord-258230-s4ty52kb 105 11 is be VBZ cord-258230-s4ty52kb 105 12 essential essential JJ cord-258230-s4ty52kb 105 13 to to TO cord-258230-s4ty52kb 105 14 evaluate evaluate VB cord-258230-s4ty52kb 105 15 the the DT cord-258230-s4ty52kb 105 16 clinical clinical JJ cord-258230-s4ty52kb 105 17 outcomes outcome NNS cord-258230-s4ty52kb 105 18 in in IN cord-258230-s4ty52kb 105 19 COVID-19 covid-19 JJ cord-258230-s4ty52kb 105 20 patients patient NNS cord-258230-s4ty52kb 105 21 on on IN cord-258230-s4ty52kb 105 22 ACEIs acei NNS cord-258230-s4ty52kb 105 23 / / SYM cord-258230-s4ty52kb 105 24 ARBs arb NNS cord-258230-s4ty52kb 105 25 in in IN cord-258230-s4ty52kb 105 26 future future JJ cord-258230-s4ty52kb 105 27 large large JJ cord-258230-s4ty52kb 105 28 studies study NNS cord-258230-s4ty52kb 105 29 , , , cord-258230-s4ty52kb 105 30 particularly particularly RB cord-258230-s4ty52kb 105 31 randomized randomize VBN cord-258230-s4ty52kb 105 32 controlled control VBN cord-258230-s4ty52kb 105 33 trials trial NNS cord-258230-s4ty52kb 105 34 , , , cord-258230-s4ty52kb 105 35 and and CC cord-258230-s4ty52kb 105 36 additionally additionally RB cord-258230-s4ty52kb 105 37 evaluate evaluate VB cord-258230-s4ty52kb 105 38 the the DT cord-258230-s4ty52kb 105 39 association association NN cord-258230-s4ty52kb 105 40 of of IN cord-258230-s4ty52kb 105 41 clinical clinical JJ cord-258230-s4ty52kb 105 42 outcomes outcome NNS cord-258230-s4ty52kb 105 43 with with IN cord-258230-s4ty52kb 105 44 ACE2 ACE2 NNP cord-258230-s4ty52kb 105 45 polymorphisms polymorphism NNS cord-258230-s4ty52kb 105 46 . . . cord-258230-s4ty52kb 106 1 Based base VBN cord-258230-s4ty52kb 106 2 on on IN cord-258230-s4ty52kb 106 3 this this DT cord-258230-s4ty52kb 106 4 , , , cord-258230-s4ty52kb 106 5 there there EX cord-258230-s4ty52kb 106 6 are be VBP cord-258230-s4ty52kb 106 7 ongoing ongoing JJ cord-258230-s4ty52kb 106 8 trials trial NNS cord-258230-s4ty52kb 106 9 studying study VBG cord-258230-s4ty52kb 106 10 the the DT cord-258230-s4ty52kb 106 11 effect effect NN cord-258230-s4ty52kb 106 12 of of IN cord-258230-s4ty52kb 106 13 losartan losartan NNP cord-258230-s4ty52kb 106 14 ( ( -LRB- cord-258230-s4ty52kb 106 15 an an DT cord-258230-s4ty52kb 106 16 ARB ARB NNP cord-258230-s4ty52kb 106 17 ) ) -RRB- cord-258230-s4ty52kb 106 18 in in IN cord-258230-s4ty52kb 106 19 patients patient NNS cord-258230-s4ty52kb 106 20 with with IN cord-258230-s4ty52kb 106 21 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 106 22 in in IN cord-258230-s4ty52kb 106 23 outpatient outpatient NN cord-258230-s4ty52kb 106 24 and and CC cord-258230-s4ty52kb 106 25 inpatient inpatient JJ cord-258230-s4ty52kb 106 26 settings setting NNS cord-258230-s4ty52kb 106 27 ( ( -LRB- cord-258230-s4ty52kb 106 28 NCT04311177 NCT04311177 NNP cord-258230-s4ty52kb 106 29 and and CC cord-258230-s4ty52kb 106 30 NCT04312009 NCT04312009 NNP cord-258230-s4ty52kb 106 31 ) ) -RRB- cord-258230-s4ty52kb 106 32 . . . cord-258230-s4ty52kb 107 1 35 35 CD cord-258230-s4ty52kb 107 2 , , , cord-258230-s4ty52kb 107 3 36 36 CD cord-258230-s4ty52kb 107 4 Conclusion conclusion NN cord-258230-s4ty52kb 108 1 It -PRON- PRP cord-258230-s4ty52kb 108 2 is be VBZ cord-258230-s4ty52kb 108 3 concluded conclude VBN cord-258230-s4ty52kb 108 4 that that IN cord-258230-s4ty52kb 108 5 ACEIs acei NNS cord-258230-s4ty52kb 108 6 and and CC cord-258230-s4ty52kb 108 7 ARBs arb NNS cord-258230-s4ty52kb 108 8 should should MD cord-258230-s4ty52kb 108 9 be be VB cord-258230-s4ty52kb 108 10 continued continue VBN cord-258230-s4ty52kb 108 11 in in IN cord-258230-s4ty52kb 108 12 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 108 13 patients patient NNS cord-258230-s4ty52kb 108 14 , , , cord-258230-s4ty52kb 108 15 reinforcing reinforce VBG cord-258230-s4ty52kb 108 16 the the DT cord-258230-s4ty52kb 108 17 recommendations recommendation NNS cord-258230-s4ty52kb 108 18 made make VBN cord-258230-s4ty52kb 108 19 by by IN cord-258230-s4ty52kb 108 20 several several JJ cord-258230-s4ty52kb 108 21 medical medical JJ cord-258230-s4ty52kb 108 22 societies society NNS cord-258230-s4ty52kb 108 23 . . . cord-258230-s4ty52kb 109 1 Additionally additionally RB cord-258230-s4ty52kb 109 2 , , , cord-258230-s4ty52kb 109 3 the the DT cord-258230-s4ty52kb 109 4 individual individual JJ cord-258230-s4ty52kb 109 5 patient patient NN cord-258230-s4ty52kb 109 6 factors factor NNS cord-258230-s4ty52kb 109 7 such such JJ cord-258230-s4ty52kb 109 8 as as IN cord-258230-s4ty52kb 109 9 ACE2 ACE2 NNP cord-258230-s4ty52kb 109 10 polymorphisms polymorphism NNS cord-258230-s4ty52kb 109 11 which which WDT cord-258230-s4ty52kb 109 12 might may MD cord-258230-s4ty52kb 109 13 confer confer VB cord-258230-s4ty52kb 109 14 higher high JJR cord-258230-s4ty52kb 109 15 risk risk NN cord-258230-s4ty52kb 109 16 of of IN cord-258230-s4ty52kb 109 17 adverse adverse JJ cord-258230-s4ty52kb 109 18 outcomes outcome NNS cord-258230-s4ty52kb 109 19 need need VBP cord-258230-s4ty52kb 109 20 to to TO cord-258230-s4ty52kb 109 21 be be VB cord-258230-s4ty52kb 109 22 evaluated evaluate VBN cord-258230-s4ty52kb 109 23 further further RB cord-258230-s4ty52kb 109 24 . . . cord-258230-s4ty52kb 110 1 A.G. A.G. NNP cord-258230-s4ty52kb 110 2 : : : cord-258230-s4ty52kb 110 3 conception conception NN cord-258230-s4ty52kb 110 4 and and CC cord-258230-s4ty52kb 110 5 design design NN cord-258230-s4ty52kb 110 6 , , , cord-258230-s4ty52kb 110 7 data datum NNS cord-258230-s4ty52kb 110 8 acquisition acquisition NN cord-258230-s4ty52kb 110 9 and and CC cord-258230-s4ty52kb 110 10 analysis analysis NN cord-258230-s4ty52kb 110 11 , , , cord-258230-s4ty52kb 110 12 drafting draft VBG cord-258230-s4ty52kb 110 13 the the DT cord-258230-s4ty52kb 110 14 manuscript manuscript NN cord-258230-s4ty52kb 110 15 , , , cord-258230-s4ty52kb 110 16 and and CC cord-258230-s4ty52kb 110 17 final final JJ cord-258230-s4ty52kb 110 18 approval approval NN cord-258230-s4ty52kb 110 19 of of IN cord-258230-s4ty52kb 110 20 the the DT cord-258230-s4ty52kb 110 21 manuscript manuscript NN cord-258230-s4ty52kb 110 22 . . . cord-258230-s4ty52kb 111 1 M.O. M.O. NNP cord-258230-s4ty52kb 111 2 : : : cord-258230-s4ty52kb 111 3 data datum NNS cord-258230-s4ty52kb 111 4 acquisition acquisition NN cord-258230-s4ty52kb 111 5 , , , cord-258230-s4ty52kb 111 6 drafting draft VBG cord-258230-s4ty52kb 111 7 and and CC cord-258230-s4ty52kb 111 8 final final JJ cord-258230-s4ty52kb 111 9 approval approval NN cord-258230-s4ty52kb 111 10 of of IN cord-258230-s4ty52kb 111 11 the the DT cord-258230-s4ty52kb 111 12 manuscript manuscript NN cord-258230-s4ty52kb 111 13 . . . cord-258230-s4ty52kb 112 1 Supplementary supplementary JJ cord-258230-s4ty52kb 112 2 material material NN cord-258230-s4ty52kb 112 3 is be VBZ cord-258230-s4ty52kb 112 4 available available JJ cord-258230-s4ty52kb 112 5 at at IN cord-258230-s4ty52kb 112 6 European European NNP cord-258230-s4ty52kb 112 7 Heart Heart NNP cord-258230-s4ty52kb 112 8 Journal Journal NNP cord-258230-s4ty52kb 112 9 -Cardiovascular -Cardiovascular . cord-258230-s4ty52kb 113 1 Pharmacotherapy Pharmacotherapy NNP cord-258230-s4ty52kb 113 2 online online RB cord-258230-s4ty52kb 113 3 . . . cord-258230-s4ty52kb 114 1 Outbreak outbreak NN cord-258230-s4ty52kb 114 2 of of IN cord-258230-s4ty52kb 114 3 a a DT cord-258230-s4ty52kb 114 4 novel novel JJ cord-258230-s4ty52kb 114 5 coronavirus coronavirus NN cord-258230-s4ty52kb 114 6 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 114 7 Map Map NNP cord-258230-s4ty52kb 114 8 -Johns -johns WDT cord-258230-s4ty52kb 114 9 Hopkins Hopkins NNP cord-258230-s4ty52kb 114 10 Coronavirus Coronavirus NNP cord-258230-s4ty52kb 114 11 Resource Resource NNP cord-258230-s4ty52kb 114 12 Cente Cente NNP cord-258230-s4ty52kb 114 13 Prevalence prevalence NN cord-258230-s4ty52kb 114 14 and and CC cord-258230-s4ty52kb 114 15 impact impact NN cord-258230-s4ty52kb 114 16 of of IN cord-258230-s4ty52kb 114 17 cardiovascular cardiovascular JJ cord-258230-s4ty52kb 114 18 metabolic metabolic JJ cord-258230-s4ty52kb 114 19 diseases disease NNS cord-258230-s4ty52kb 114 20 on on IN cord-258230-s4ty52kb 114 21 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 114 22 in in IN cord-258230-s4ty52kb 114 23 China China NNP cord-258230-s4ty52kb 115 1 Renin renin NN cord-258230-s4ty52kb 115 2 - - HYPH cord-258230-s4ty52kb 115 3 angiotensin angiotensin NN cord-258230-s4ty52kb 115 4 - - HYPH cord-258230-s4ty52kb 115 5 aldosterone aldosterone NN cord-258230-s4ty52kb 115 6 system system NN cord-258230-s4ty52kb 115 7 inhibitors inhibitor NNS cord-258230-s4ty52kb 115 8 in in IN cord-258230-s4ty52kb 115 9 patients patient NNS cord-258230-s4ty52kb 115 10 with with IN cord-258230-s4ty52kb 115 11 Covid-19 Covid-19 NNP cord-258230-s4ty52kb 115 12 Ambiguities Ambiguities NNPS cord-258230-s4ty52kb 115 13 in in IN cord-258230-s4ty52kb 115 14 the the DT cord-258230-s4ty52kb 115 15 guidelines guideline NNS cord-258230-s4ty52kb 115 16 for for IN cord-258230-s4ty52kb 115 17 the the DT cord-258230-s4ty52kb 115 18 management management NN cord-258230-s4ty52kb 115 19 of of IN cord-258230-s4ty52kb 115 20 arterial arterial JJ cord-258230-s4ty52kb 115 21 hypertension hypertension NN cord-258230-s4ty52kb 115 22 : : : cord-258230-s4ty52kb 116 1 Indian indian JJ cord-258230-s4ty52kb 116 2 perspective perspective NN cord-258230-s4ty52kb 116 3 with with IN cord-258230-s4ty52kb 116 4 a a DT cord-258230-s4ty52kb 116 5 call call NN cord-258230-s4ty52kb 116 6 for for IN cord-258230-s4ty52kb 116 7 global global JJ cord-258230-s4ty52kb 116 8 harmonization harmonization NN cord-258230-s4ty52kb 116 9 Receptor Receptor NNP cord-258230-s4ty52kb 116 10 recognition recognition NN cord-258230-s4ty52kb 116 11 by by IN cord-258230-s4ty52kb 116 12 the the DT cord-258230-s4ty52kb 116 13 novel novel JJ cord-258230-s4ty52kb 116 14 coronavirus coronavirus NN cord-258230-s4ty52kb 116 15 from from IN cord-258230-s4ty52kb 116 16 Wuhan Wuhan NNP cord-258230-s4ty52kb 116 17 : : : cord-258230-s4ty52kb 116 18 an an DT cord-258230-s4ty52kb 116 19 analysis analysis NN cord-258230-s4ty52kb 116 20 based base VBN cord-258230-s4ty52kb 116 21 on on IN cord-258230-s4ty52kb 116 22 decade decade NN cord-258230-s4ty52kb 116 23 - - HYPH cord-258230-s4ty52kb 116 24 long long JJ cord-258230-s4ty52kb 116 25 structural structural JJ cord-258230-s4ty52kb 116 26 studies study NNS cord-258230-s4ty52kb 116 27 of of IN cord-258230-s4ty52kb 116 28 SARS SARS NNP cord-258230-s4ty52kb 116 29 coronavirus coronavirus NN cord-258230-s4ty52kb 116 30 Risks risk NNS cord-258230-s4ty52kb 116 31 of of IN cord-258230-s4ty52kb 116 32 ACE ace NN cord-258230-s4ty52kb 116 33 inhibitor inhibitor NN cord-258230-s4ty52kb 116 34 and and CC cord-258230-s4ty52kb 116 35 ARB ARB NNP cord-258230-s4ty52kb 116 36 usage usage NN cord-258230-s4ty52kb 116 37 in in IN cord-258230-s4ty52kb 116 38 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 116 39 : : : cord-258230-s4ty52kb 116 40 evaluating evaluate VBG cord-258230-s4ty52kb 116 41 the the DT cord-258230-s4ty52kb 116 42 evidence evidence NN cord-258230-s4ty52kb 116 43 Position Position NNP cord-258230-s4ty52kb 116 44 Statement Statement NNP cord-258230-s4ty52kb 116 45 of of IN cord-258230-s4ty52kb 116 46 the the DT cord-258230-s4ty52kb 116 47 ESC ESC NNP cord-258230-s4ty52kb 116 48 Council Council NNP cord-258230-s4ty52kb 116 49 on on IN cord-258230-s4ty52kb 116 50 Hypertension Hypertension NNP cord-258230-s4ty52kb 116 51 on on IN cord-258230-s4ty52kb 116 52 ACE ACE NNP cord-258230-s4ty52kb 116 53 - - HYPH cord-258230-s4ty52kb 116 54 Inhibitors Inhibitors NNP cord-258230-s4ty52kb 116 55 and and CC cord-258230-s4ty52kb 116 56 Angiotensin Angiotensin NNP cord-258230-s4ty52kb 116 57 Receptor Receptor NNP cord-258230-s4ty52kb 116 58 Blockers Blockers NNP cord-258230-s4ty52kb 117 1 Should Should MD cord-258230-s4ty52kb 117 2 patients patient NNS cord-258230-s4ty52kb 117 3 receiving receive VBG cord-258230-s4ty52kb 117 4 ACE ace NN cord-258230-s4ty52kb 117 5 inhibitors inhibitor NNS cord-258230-s4ty52kb 117 6 or or CC cord-258230-s4ty52kb 117 7 angiotensin angiotensin NN cord-258230-s4ty52kb 117 8 receptor receptor NN cord-258230-s4ty52kb 117 9 blockers blocker NNS cord-258230-s4ty52kb 117 10 be be VB cord-258230-s4ty52kb 117 11 switched switch VBN cord-258230-s4ty52kb 117 12 to to IN cord-258230-s4ty52kb 117 13 other other JJ cord-258230-s4ty52kb 117 14 antihypertensive antihypertensive JJ cord-258230-s4ty52kb 117 15 drugs drug NNS cord-258230-s4ty52kb 117 16 to to TO cord-258230-s4ty52kb 117 17 prevent prevent VB cord-258230-s4ty52kb 117 18 or or CC cord-258230-s4ty52kb 117 19 improve improve VB cord-258230-s4ty52kb 117 20 prognosis prognosis NN cord-258230-s4ty52kb 117 21 of of IN cord-258230-s4ty52kb 117 22 novel novel JJ cord-258230-s4ty52kb 117 23 coronavirus coronavirus NN cord-258230-s4ty52kb 117 24 disease disease NN cord-258230-s4ty52kb 117 25 2019 2019 CD cord-258230-s4ty52kb 117 26 ( ( -LRB- cord-258230-s4ty52kb 117 27 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 117 28 ) ) -RRB- cord-258230-s4ty52kb 117 29 ? ? . cord-258230-s4ty52kb 118 1 The the DT cord-258230-s4ty52kb 118 2 International International NNP cord-258230-s4ty52kb 118 3 Society Society NNP cord-258230-s4ty52kb 118 4 of of IN cord-258230-s4ty52kb 118 5 Hypertension Hypertension NNP cord-258230-s4ty52kb 118 6 . . . cord-258230-s4ty52kb 119 1 A a DT cord-258230-s4ty52kb 119 2 statement statement NN cord-258230-s4ty52kb 119 3 from from IN cord-258230-s4ty52kb 119 4 the the DT cord-258230-s4ty52kb 119 5 International International NNP cord-258230-s4ty52kb 119 6 Society Society NNP cord-258230-s4ty52kb 119 7 of of IN cord-258230-s4ty52kb 119 8 Hypertension Hypertension NNP cord-258230-s4ty52kb 119 9 on on IN cord-258230-s4ty52kb 119 10 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 119 11 HFSA HFSA NNP cord-258230-s4ty52kb 119 12 / / SYM cord-258230-s4ty52kb 119 13 ACC ACC NNP cord-258230-s4ty52kb 120 1 /AHA /AHA , cord-258230-s4ty52kb 120 2 Statement statement NN cord-258230-s4ty52kb 121 1 Addresses address NNS cord-258230-s4ty52kb 121 2 Concerns concern NNS cord-258230-s4ty52kb 121 3 Re re IN cord-258230-s4ty52kb 121 4 : : : cord-258230-s4ty52kb 121 5 Using use VBG cord-258230-s4ty52kb 121 6 RAAS RAAS NNP cord-258230-s4ty52kb 121 7 Antagonists Antagonists NNPS cord-258230-s4ty52kb 121 8 in in IN cord-258230-s4ty52kb 121 9 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 121 10 -American -American NNP cord-258230-s4ty52kb 121 11 College College NNP cord-258230-s4ty52kb 121 12 of of IN cord-258230-s4ty52kb 121 13 Cardiology Cardiology NNP cord-258230-s4ty52kb 122 1 The the DT cord-258230-s4ty52kb 122 2 Newcastle Newcastle NNP cord-258230-s4ty52kb 122 3 - - HYPH cord-258230-s4ty52kb 122 4 Ottawa Ottawa NNP cord-258230-s4ty52kb 122 5 Scale Scale NNP cord-258230-s4ty52kb 122 6 ( ( -LRB- cord-258230-s4ty52kb 122 7 NOS NOS NNP cord-258230-s4ty52kb 122 8 ) ) -RRB- cord-258230-s4ty52kb 122 9 for for IN cord-258230-s4ty52kb 122 10 assessing assess VBG cord-258230-s4ty52kb 122 11 the the DT cord-258230-s4ty52kb 122 12 quality quality NN cord-258230-s4ty52kb 122 13 of of IN cord-258230-s4ty52kb 122 14 nonrandomised nonrandomise VBN cord-258230-s4ty52kb 122 15 studies study NNS cord-258230-s4ty52kb 122 16 in in IN cord-258230-s4ty52kb 122 17 meta meta NNP cord-258230-s4ty52kb 122 18 - - HYPH cord-258230-s4ty52kb 122 19 analyses analysis NNS cord-258230-s4ty52kb 123 1 Renin renin NN cord-258230-s4ty52kb 123 2 - - HYPH cord-258230-s4ty52kb 123 3 angiotensin angiotensin NN cord-258230-s4ty52kb 123 4 system system NN cord-258230-s4ty52kb 123 5 inhibitors inhibitor NNS cord-258230-s4ty52kb 123 6 improve improve VBP cord-258230-s4ty52kb 123 7 the the DT cord-258230-s4ty52kb 123 8 clinical clinical JJ cord-258230-s4ty52kb 123 9 outcomes outcome NNS cord-258230-s4ty52kb 123 10 of of IN cord-258230-s4ty52kb 123 11 COVID-19 covid-19 JJ cord-258230-s4ty52kb 123 12 patients patient NNS cord-258230-s4ty52kb 123 13 with with IN cord-258230-s4ty52kb 123 14 hypertension hypertension NN cord-258230-s4ty52kb 124 1 Presenting present VBG cord-258230-s4ty52kb 124 2 characteristics characteristic NNS cord-258230-s4ty52kb 124 3 , , , cord-258230-s4ty52kb 124 4 comorbidities comorbiditie NNS cord-258230-s4ty52kb 124 5 , , , cord-258230-s4ty52kb 124 6 and and CC cord-258230-s4ty52kb 124 7 outcomes outcome NNS cord-258230-s4ty52kb 124 8 among among IN cord-258230-s4ty52kb 124 9 5700 5700 CD cord-258230-s4ty52kb 124 10 patients patient NNS cord-258230-s4ty52kb 124 11 hospitalized hospitalize VBN cord-258230-s4ty52kb 124 12 with with IN cord-258230-s4ty52kb 124 13 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 124 14 in in IN cord-258230-s4ty52kb 124 15 the the DT cord-258230-s4ty52kb 124 16 New New NNP cord-258230-s4ty52kb 124 17 York York NNP cord-258230-s4ty52kb 124 18 City City NNP cord-258230-s4ty52kb 124 19 area area NN cord-258230-s4ty52kb 124 20 Role role NN cord-258230-s4ty52kb 124 21 of of IN cord-258230-s4ty52kb 124 22 drugs drug NNS cord-258230-s4ty52kb 124 23 affecting affect VBG cord-258230-s4ty52kb 124 24 the the DT cord-258230-s4ty52kb 124 25 renin renin NN cord-258230-s4ty52kb 124 26 - - HYPH cord-258230-s4ty52kb 124 27 angiotensin angiotensin NN cord-258230-s4ty52kb 124 28 - - HYPH cord-258230-s4ty52kb 124 29 aldosterone aldosterone NN cord-258230-s4ty52kb 124 30 system system NN cord-258230-s4ty52kb 124 31 on on IN cord-258230-s4ty52kb 124 32 susceptibility susceptibility NN cord-258230-s4ty52kb 124 33 and and CC cord-258230-s4ty52kb 124 34 severity severity NN cord-258230-s4ty52kb 124 35 of of IN cord-258230-s4ty52kb 124 36 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 124 37 : : : cord-258230-s4ty52kb 124 38 a a DT cord-258230-s4ty52kb 124 39 large large JJ cord-258230-s4ty52kb 124 40 case case NN cord-258230-s4ty52kb 124 41 - - HYPH cord-258230-s4ty52kb 124 42 control control NN cord-258230-s4ty52kb 124 43 study study NN cord-258230-s4ty52kb 124 44 from from IN cord-258230-s4ty52kb 124 45 Zheijang Zheijang NNP cord-258230-s4ty52kb 124 46 Province Province NNP cord-258230-s4ty52kb 124 47 , , , cord-258230-s4ty52kb 124 48 China China NNP cord-258230-s4ty52kb 124 49 Renin Renin NNP cord-258230-s4ty52kb 124 50 - - HYPH cord-258230-s4ty52kb 124 51 angiotensin angiotensin NN cord-258230-s4ty52kb 124 52 - - HYPH cord-258230-s4ty52kb 124 53 aldosterone aldosterone NN cord-258230-s4ty52kb 124 54 system system NN cord-258230-s4ty52kb 124 55 blockers blocker NNS cord-258230-s4ty52kb 124 56 and and CC cord-258230-s4ty52kb 124 57 the the DT cord-258230-s4ty52kb 124 58 risk risk NN cord-258230-s4ty52kb 124 59 of of IN cord-258230-s4ty52kb 124 60 Covid-19 Covid-19 NNP cord-258230-s4ty52kb 124 61 Cardiovascular Cardiovascular NNP cord-258230-s4ty52kb 124 62 disease disease NN cord-258230-s4ty52kb 124 63 , , , cord-258230-s4ty52kb 124 64 drug drug NN cord-258230-s4ty52kb 124 65 therapy therapy NN cord-258230-s4ty52kb 124 66 , , , cord-258230-s4ty52kb 124 67 and and CC cord-258230-s4ty52kb 124 68 mortality mortality NN cord-258230-s4ty52kb 124 69 in in IN cord-258230-s4ty52kb 124 70 Covid-19 Covid-19 NNP cord-258230-s4ty52kb 124 71 Renin Renin NNP cord-258230-s4ty52kb 124 72 - - HYPH cord-258230-s4ty52kb 124 73 angiotensin angiotensin NN cord-258230-s4ty52kb 124 74 - - HYPH cord-258230-s4ty52kb 124 75 aldosterone aldosterone NN cord-258230-s4ty52kb 124 76 system system NN cord-258230-s4ty52kb 124 77 inhibitors inhibitor NNS cord-258230-s4ty52kb 124 78 and and CC cord-258230-s4ty52kb 124 79 risk risk NN cord-258230-s4ty52kb 124 80 of of IN cord-258230-s4ty52kb 124 81 Covid-19 Covid-19 NNP cord-258230-s4ty52kb 124 82 Amouyel Amouyel NNP cord-258230-s4ty52kb 124 83 P P NNP cord-258230-s4ty52kb 124 84 , , , cord-258230-s4ty52kb 124 85 on on IN cord-258230-s4ty52kb 124 86 behalf behalf NN cord-258230-s4ty52kb 124 87 of of IN cord-258230-s4ty52kb 124 88 the the DT cord-258230-s4ty52kb 124 89 Lille Lille NNP cord-258230-s4ty52kb 124 90 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 124 91 study study NN cord-258230-s4ty52kb 124 92 group group NN cord-258230-s4ty52kb 124 93 . . . cord-258230-s4ty52kb 125 1 ACE ACE NNP cord-258230-s4ty52kb 125 2 inhibitors inhibitor NNS cord-258230-s4ty52kb 125 3 , , , cord-258230-s4ty52kb 125 4 AT1 at1 NN cord-258230-s4ty52kb 125 5 receptor receptor NN cord-258230-s4ty52kb 125 6 blockers blocker NNS cord-258230-s4ty52kb 125 7 and and CC cord-258230-s4ty52kb 125 8 COVID-19 covid-19 VB cord-258230-s4ty52kb 125 9 : : : cord-258230-s4ty52kb 125 10 clinical clinical JJ cord-258230-s4ty52kb 125 11 epidemiology epidemiology NN cord-258230-s4ty52kb 125 12 evidences evidence NNS cord-258230-s4ty52kb 125 13 for for IN cord-258230-s4ty52kb 125 14 a a DT cord-258230-s4ty52kb 125 15 continuation continuation NN cord-258230-s4ty52kb 125 16 of of IN cord-258230-s4ty52kb 125 17 treatments treatment NNS cord-258230-s4ty52kb 125 18 . . . cord-258230-s4ty52kb 126 1 The the DT cord-258230-s4ty52kb 126 2 ACER ACER NNP cord-258230-s4ty52kb 126 3 - - HYPH cord-258230-s4ty52kb 126 4 COVID COVID NNP cord-258230-s4ty52kb 126 5 study study NN cord-258230-s4ty52kb 126 6 Association Association NNP cord-258230-s4ty52kb 126 7 of of IN cord-258230-s4ty52kb 126 8 inpatient inpatient JJ cord-258230-s4ty52kb 126 9 use use NN cord-258230-s4ty52kb 126 10 of of IN cord-258230-s4ty52kb 126 11 angiotensin angiotensin NN cord-258230-s4ty52kb 126 12 converting convert VBG cord-258230-s4ty52kb 126 13 enzyme enzyme NN cord-258230-s4ty52kb 126 14 inhibitors inhibitor NNS cord-258230-s4ty52kb 126 15 and and CC cord-258230-s4ty52kb 126 16 angiotensin angiotensin NN cord-258230-s4ty52kb 126 17 II ii CD cord-258230-s4ty52kb 126 18 receptor receptor NN cord-258230-s4ty52kb 126 19 blockers blocker NNS cord-258230-s4ty52kb 126 20 with with IN cord-258230-s4ty52kb 126 21 mortality mortality NN cord-258230-s4ty52kb 126 22 among among IN cord-258230-s4ty52kb 126 23 patients patient NNS cord-258230-s4ty52kb 126 24 with with IN cord-258230-s4ty52kb 126 25 hypertension hypertension NN cord-258230-s4ty52kb 126 26 hospitalized hospitalize VBN cord-258230-s4ty52kb 126 27 with with IN cord-258230-s4ty52kb 126 28 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 126 29 Association Association NNP cord-258230-s4ty52kb 126 30 of of IN cord-258230-s4ty52kb 126 31 renin renin NN cord-258230-s4ty52kb 126 32 - - HYPH cord-258230-s4ty52kb 126 33 angiotensin angiotensin NN cord-258230-s4ty52kb 126 34 system system NN cord-258230-s4ty52kb 126 35 inhibitors inhibitor NNS cord-258230-s4ty52kb 126 36 with with IN cord-258230-s4ty52kb 126 37 severity severity NN cord-258230-s4ty52kb 126 38 or or CC cord-258230-s4ty52kb 126 39 risk risk NN cord-258230-s4ty52kb 126 40 of of IN cord-258230-s4ty52kb 126 41 death death NN cord-258230-s4ty52kb 126 42 in in IN cord-258230-s4ty52kb 126 43 patients patient NNS cord-258230-s4ty52kb 126 44 with with IN cord-258230-s4ty52kb 126 45 hypertension hypertension NN cord-258230-s4ty52kb 126 46 hospitalized hospitalize VBN cord-258230-s4ty52kb 126 47 for for IN cord-258230-s4ty52kb 126 48 coronavirus coronavirus NN cord-258230-s4ty52kb 126 49 disease disease NN cord-258230-s4ty52kb 126 50 2019 2019 CD cord-258230-s4ty52kb 126 51 ( ( -LRB- cord-258230-s4ty52kb 126 52 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 126 53 ) ) -RRB- cord-258230-s4ty52kb 126 54 infection infection NN cord-258230-s4ty52kb 126 55 in in IN cord-258230-s4ty52kb 126 56 Wuhan Wuhan NNP cord-258230-s4ty52kb 126 57 , , , cord-258230-s4ty52kb 126 58 China China NNP cord-258230-s4ty52kb 126 59 Anti Anti NNP cord-258230-s4ty52kb 126 60 - - JJ cord-258230-s4ty52kb 126 61 hypertensive hypertensive JJ cord-258230-s4ty52kb 126 62 angiotensin angiotensin NN cord-258230-s4ty52kb 126 63 II II NNP cord-258230-s4ty52kb 126 64 receptor receptor NN cord-258230-s4ty52kb 126 65 blockers blocker NNS cord-258230-s4ty52kb 126 66 associated associate VBN cord-258230-s4ty52kb 126 67 to to IN cord-258230-s4ty52kb 126 68 mitigation mitigation NN cord-258230-s4ty52kb 126 69 of of IN cord-258230-s4ty52kb 126 70 disease disease NN cord-258230-s4ty52kb 126 71 severity severity NN cord-258230-s4ty52kb 126 72 in in IN cord-258230-s4ty52kb 126 73 elderly elderly JJ cord-258230-s4ty52kb 126 74 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 126 75 patients patient NNS cord-258230-s4ty52kb 126 76 COVID-19 covid-19 VBP cord-258230-s4ty52kb 126 77 with with IN cord-258230-s4ty52kb 126 78 different different JJ cord-258230-s4ty52kb 126 79 severity severity NN cord-258230-s4ty52kb 126 80 : : : cord-258230-s4ty52kb 126 81 a a DT cord-258230-s4ty52kb 126 82 multi multi JJ cord-258230-s4ty52kb 126 83 - - JJ cord-258230-s4ty52kb 126 84 center center JJ cord-258230-s4ty52kb 126 85 study study NN cord-258230-s4ty52kb 126 86 of of IN cord-258230-s4ty52kb 126 87 clinical clinical JJ cord-258230-s4ty52kb 126 88 features feature NNS cord-258230-s4ty52kb 126 89 . . . cord-258230-s4ty52kb 127 1 COVID-19 covid-19 VB cord-258230-s4ty52kb 127 2 with with IN cord-258230-s4ty52kb 127 3 different different JJ cord-258230-s4ty52kb 127 4 severity severity NN cord-258230-s4ty52kb 127 5 : : : cord-258230-s4ty52kb 127 6 a a DT cord-258230-s4ty52kb 127 7 multi multi JJ cord-258230-s4ty52kb 127 8 - - JJ cord-258230-s4ty52kb 127 9 center center JJ cord-258230-s4ty52kb 127 10 study study NN cord-258230-s4ty52kb 127 11 of of IN cord-258230-s4ty52kb 127 12 clinical clinical JJ cord-258230-s4ty52kb 127 13 features feature VBZ cord-258230-s4ty52kb 127 14 Cardiovascular cardiovascular JJ cord-258230-s4ty52kb 127 15 implications implication NNS cord-258230-s4ty52kb 127 16 of of IN cord-258230-s4ty52kb 127 17 fatal fatal JJ cord-258230-s4ty52kb 127 18 outcomes outcome NNS cord-258230-s4ty52kb 127 19 of of IN cord-258230-s4ty52kb 127 20 patients patient NNS cord-258230-s4ty52kb 127 21 with with IN cord-258230-s4ty52kb 127 22 coronavirus coronavirus NN cord-258230-s4ty52kb 127 23 disease disease NN cord-258230-s4ty52kb 127 24 2019 2019 CD cord-258230-s4ty52kb 127 25 ( ( -LRB- cord-258230-s4ty52kb 127 26 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 127 27 ) ) -RRB- cord-258230-s4ty52kb 127 28 Treatment treatment NN cord-258230-s4ty52kb 127 29 with with IN cord-258230-s4ty52kb 127 30 ACE ace NN cord-258230-s4ty52kb 127 31 - - HYPH cord-258230-s4ty52kb 127 32 inhibitors inhibitor NNS cord-258230-s4ty52kb 127 33 is be VBZ cord-258230-s4ty52kb 127 34 associated associate VBN cord-258230-s4ty52kb 127 35 with with IN cord-258230-s4ty52kb 127 36 less less RBR cord-258230-s4ty52kb 127 37 severe severe JJ cord-258230-s4ty52kb 127 38 disease disease NN cord-258230-s4ty52kb 127 39 with with IN cord-258230-s4ty52kb 127 40 SARS SARS NNP cord-258230-s4ty52kb 127 41 - - HYPH cord-258230-s4ty52kb 127 42 Covid-19 Covid-19 NNP cord-258230-s4ty52kb 127 43 infection infection NN cord-258230-s4ty52kb 127 44 in in IN cord-258230-s4ty52kb 127 45 a a DT cord-258230-s4ty52kb 127 46 multi multi JJ cord-258230-s4ty52kb 127 47 - - JJ cord-258230-s4ty52kb 127 48 site site NN cord-258230-s4ty52kb 127 49 UK UK NNP cord-258230-s4ty52kb 127 50 acute acute NN cord-258230-s4ty52kb 127 51 Hospital Hospital NNP cord-258230-s4ty52kb 127 52 Trust Trust NNP cord-258230-s4ty52kb 127 53 Effects effect NNS cord-258230-s4ty52kb 127 54 of of IN cord-258230-s4ty52kb 127 55 ARBs arb NNS cord-258230-s4ty52kb 127 56 and and CC cord-258230-s4ty52kb 127 57 ACEIs acei NNS cord-258230-s4ty52kb 127 58 on on IN cord-258230-s4ty52kb 127 59 virus virus NN cord-258230-s4ty52kb 127 60 infection infection NN cord-258230-s4ty52kb 127 61 , , , cord-258230-s4ty52kb 127 62 inflammatory inflammatory JJ cord-258230-s4ty52kb 127 63 status status NN cord-258230-s4ty52kb 127 64 and and CC cord-258230-s4ty52kb 127 65 clinical clinical JJ cord-258230-s4ty52kb 127 66 outcomes outcome NNS cord-258230-s4ty52kb 127 67 in in IN cord-258230-s4ty52kb 127 68 COVID-19 covid-19 JJ cord-258230-s4ty52kb 127 69 patients patient NNS cord-258230-s4ty52kb 127 70 with with IN cord-258230-s4ty52kb 127 71 hypertension hypertension NN cord-258230-s4ty52kb 127 72 : : : cord-258230-s4ty52kb 127 73 a a DT cord-258230-s4ty52kb 127 74 single single JJ cord-258230-s4ty52kb 127 75 center center NN cord-258230-s4ty52kb 127 76 retrospective retrospective JJ cord-258230-s4ty52kb 127 77 study study NN cord-258230-s4ty52kb 127 78 Hypertension hypertension NN cord-258230-s4ty52kb 127 79 in in IN cord-258230-s4ty52kb 127 80 patients patient NNS cord-258230-s4ty52kb 127 81 hospitalized hospitalize VBN cord-258230-s4ty52kb 127 82 with with IN cord-258230-s4ty52kb 127 83 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 127 84 in in IN cord-258230-s4ty52kb 127 85 Wuhan Wuhan NNP cord-258230-s4ty52kb 127 86 , , , cord-258230-s4ty52kb 127 87 China China NNP cord-258230-s4ty52kb 127 88 : : : cord-258230-s4ty52kb 127 89 a a DT cord-258230-s4ty52kb 127 90 singlecenter singlecenter JJ cord-258230-s4ty52kb 127 91 retrospective retrospective JJ cord-258230-s4ty52kb 127 92 observational observational JJ cord-258230-s4ty52kb 127 93 study study NN cord-258230-s4ty52kb 127 94 Hypertension hypertension NN cord-258230-s4ty52kb 127 95 and and CC cord-258230-s4ty52kb 127 96 renin renin NN cord-258230-s4ty52kb 127 97 - - HYPH cord-258230-s4ty52kb 127 98 angiotensin angiotensin NN cord-258230-s4ty52kb 127 99 - - HYPH cord-258230-s4ty52kb 127 100 aldosterone aldosterone NN cord-258230-s4ty52kb 127 101 system system NN cord-258230-s4ty52kb 127 102 inhibitors inhibitor NNS cord-258230-s4ty52kb 127 103 in in IN cord-258230-s4ty52kb 127 104 patients patient NNS cord-258230-s4ty52kb 127 105 with with IN cord-258230-s4ty52kb 127 106 Covid-19 Covid-19 NNP cord-258230-s4ty52kb 127 107 Chinese Chinese NNP cord-258230-s4ty52kb 127 108 Clinical Clinical NNP cord-258230-s4ty52kb 127 109 Guidance Guidance NNP cord-258230-s4ty52kb 127 110 for for IN cord-258230-s4ty52kb 127 111 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 127 112 Pneumonia Pneumonia NNP cord-258230-s4ty52kb 127 113 Diagnosis Diagnosis NNP cord-258230-s4ty52kb 127 114 and and CC cord-258230-s4ty52kb 127 115 Treatment Treatment NNP cord-258230-s4ty52kb 127 116 Evaluating evaluate VBG cord-258230-s4ty52kb 127 117 the the DT cord-258230-s4ty52kb 127 118 effectiveness effectiveness NN cord-258230-s4ty52kb 127 119 of of IN cord-258230-s4ty52kb 127 120 social social JJ cord-258230-s4ty52kb 127 121 distancing distance VBG cord-258230-s4ty52kb 127 122 interventions intervention NNS cord-258230-s4ty52kb 127 123 to to TO cord-258230-s4ty52kb 127 124 delay delay VB cord-258230-s4ty52kb 127 125 or or CC cord-258230-s4ty52kb 127 126 flatten flatten VB cord-258230-s4ty52kb 127 127 the the DT cord-258230-s4ty52kb 127 128 epidemic epidemic NN cord-258230-s4ty52kb 127 129 curve curve NN cord-258230-s4ty52kb 127 130 of of IN cord-258230-s4ty52kb 127 131 coronavirus coronavirus NN cord-258230-s4ty52kb 127 132 disease disease NN cord-258230-s4ty52kb 128 1 Pö pö NN cord-258230-s4ty52kb 128 2 hlmann hlmann NN cord-258230-s4ty52kb 128 3 S. S. NNP cord-258230-s4ty52kb 128 4 SARS SARS NNP cord-258230-s4ty52kb 128 5 - - HYPH cord-258230-s4ty52kb 128 6 CoV-2 CoV-2 NNP cord-258230-s4ty52kb 128 7 cell cell NN cord-258230-s4ty52kb 128 8 entry entry NN cord-258230-s4ty52kb 128 9 depends depend VBZ cord-258230-s4ty52kb 128 10 on on IN cord-258230-s4ty52kb 128 11 ACE2 ACE2 NNP cord-258230-s4ty52kb 128 12 and and CC cord-258230-s4ty52kb 128 13 TMPRSS2 TMPRSS2 NNP cord-258230-s4ty52kb 128 14 and and CC cord-258230-s4ty52kb 128 15 is be VBZ cord-258230-s4ty52kb 128 16 blocked block VBN cord-258230-s4ty52kb 128 17 by by IN cord-258230-s4ty52kb 128 18 a a DT cord-258230-s4ty52kb 128 19 clinically clinically RB cord-258230-s4ty52kb 128 20 proven prove VBN cord-258230-s4ty52kb 128 21 protease protease NN cord-258230-s4ty52kb 128 22 inhibitor inhibitor NN cord-258230-s4ty52kb 128 23 Outcomes outcome NNS cord-258230-s4ty52kb 128 24 in in IN cord-258230-s4ty52kb 128 25 patients patient NNS cord-258230-s4ty52kb 128 26 with with IN cord-258230-s4ty52kb 128 27 COVID-19 covid-19 JJ cord-258230-s4ty52kb 128 28 infection infection NN cord-258230-s4ty52kb 128 29 taking take VBG cord-258230-s4ty52kb 128 30 ACEI ACEI NNP cord-258230-s4ty52kb 128 31 / / SYM cord-258230-s4ty52kb 128 32 ARB ARB NNP cord-258230-s4ty52kb 129 1 Are be VBP cord-258230-s4ty52kb 129 2 patients patient NNS cord-258230-s4ty52kb 129 3 with with IN cord-258230-s4ty52kb 129 4 hypertension hypertension NN cord-258230-s4ty52kb 129 5 and and CC cord-258230-s4ty52kb 129 6 diabetes diabetes NN cord-258230-s4ty52kb 129 7 mellitus mellitus NN cord-258230-s4ty52kb 129 8 at at IN cord-258230-s4ty52kb 129 9 increased increase VBN cord-258230-s4ty52kb 129 10 risk risk NN cord-258230-s4ty52kb 129 11 for for IN cord-258230-s4ty52kb 129 12 COVID-19 covid-19 JJ cord-258230-s4ty52kb 129 13 infection infection NN cord-258230-s4ty52kb 129 14 ? ? . cord-258230-s4ty52kb 130 1 Losartan Losartan NNP cord-258230-s4ty52kb 130 2 for for IN cord-258230-s4ty52kb 130 3 Patients patient NNS cord-258230-s4ty52kb 130 4 With with IN cord-258230-s4ty52kb 131 1 COVID-19 covid-19 VB cord-258230-s4ty52kb 132 1 Not not RB cord-258230-s4ty52kb 132 2 Requiring require VBG cord-258230-s4ty52kb 132 3 Hospitalization hospitalization NN cord-258230-s4ty52kb 133 1 -Full -Full . cord-258230-s4ty52kb 134 1 Text Text NNP cord-258230-s4ty52kb 134 2 View View NNP cord-258230-s4ty52kb 135 1 -ClinicalTrials -ClinicalTrials . cord-258230-s4ty52kb 136 1 Losartan Losartan NNP cord-258230-s4ty52kb 136 2 for for IN cord-258230-s4ty52kb 136 3 Patients patient NNS cord-258230-s4ty52kb 136 4 With with IN cord-258230-s4ty52kb 136 5 COVID-19 COVID-19 NNP cord-258230-s4ty52kb 137 1 Requiring require VBG cord-258230-s4ty52kb 137 2 Hospitalization hospitalization NN cord-258230-s4ty52kb 138 1 -Full -Full . cord-258230-s4ty52kb 139 1 Text Text NNP cord-258230-s4ty52kb 139 2 View View NNP cord-258230-s4ty52kb 140 1 -ClinicalTrials -ClinicalTrials . cord-258230-s4ty52kb 141 1 Data datum NNS cord-258230-s4ty52kb 141 2 availability availability NN cord-258230-s4ty52kb 141 3 statement statement NN cord-258230-s4ty52kb 141 4 : : : cord-258230-s4ty52kb 142 1 The the DT cord-258230-s4ty52kb 142 2 data datum NNS cord-258230-s4ty52kb 142 3 underlying underlie VBG cord-258230-s4ty52kb 142 4 this this DT cord-258230-s4ty52kb 142 5 article article NN cord-258230-s4ty52kb 142 6 are be VBP cord-258230-s4ty52kb 142 7 available available JJ cord-258230-s4ty52kb 142 8 in in IN cord-258230-s4ty52kb 142 9 the the DT cord-258230-s4ty52kb 142 10 article article NN cord-258230-s4ty52kb 142 11 and and CC cord-258230-s4ty52kb 142 12 in in IN cord-258230-s4ty52kb 142 13 its -PRON- PRP$ cord-258230-s4ty52kb 142 14 online online JJ cord-258230-s4ty52kb 142 15 Supplementary supplementary JJ cord-258230-s4ty52kb 142 16 material material NN cord-258230-s4ty52kb 142 17 . . .