id sid tid token lemma pos cord-257258-hu9oxea1 1 1 key key JJ cord-257258-hu9oxea1 2 1 : : : cord-257258-hu9oxea1 2 2 cord-257258-hu9oxea1 cord-257258-hu9oxea1 NNP cord-257258-hu9oxea1 2 3 authors author NNS cord-257258-hu9oxea1 2 4 : : : cord-257258-hu9oxea1 2 5 Chabner Chabner NNP cord-257258-hu9oxea1 2 6 , , , cord-257258-hu9oxea1 2 7 Bruce Bruce NNP cord-257258-hu9oxea1 2 8 A. a. NN cord-257258-hu9oxea1 2 9 title title NN cord-257258-hu9oxea1 2 10 : : : cord-257258-hu9oxea1 2 11 Taking take VBG cord-257258-hu9oxea1 2 12 the the DT cord-257258-hu9oxea1 2 13 Longer long JJR cord-257258-hu9oxea1 2 14 View view NN cord-257258-hu9oxea1 2 15 of of IN cord-257258-hu9oxea1 2 16 COVID‐19 COVID‐19 NNP cord-257258-hu9oxea1 2 17 date date NN cord-257258-hu9oxea1 2 18 : : : cord-257258-hu9oxea1 2 19 2020 2020 CD cord-257258-hu9oxea1 2 20 - - HYPH cord-257258-hu9oxea1 2 21 04 04 CD cord-257258-hu9oxea1 2 22 - - HYPH cord-257258-hu9oxea1 2 23 27 27 CD cord-257258-hu9oxea1 2 24 journal journal NN cord-257258-hu9oxea1 2 25 : : : cord-257258-hu9oxea1 3 1 Oncologist oncologist NN cord-257258-hu9oxea1 3 2 DOI doi NN cord-257258-hu9oxea1 3 3 : : : cord-257258-hu9oxea1 4 1 10.1634 10.1634 CD cord-257258-hu9oxea1 4 2 / / SYM cord-257258-hu9oxea1 4 3 theoncologist.2020 theoncologist.2020 NN cord-257258-hu9oxea1 4 4 - - HYPH cord-257258-hu9oxea1 4 5 0313 0313 CD cord-257258-hu9oxea1 4 6 sha sha NNP cord-257258-hu9oxea1 4 7 : : : cord-257258-hu9oxea1 5 1 9fb9d3ab604fb41ae5e3d83c1e5566d272a55acd 9fb9d3ab604fb41ae5e3d83c1e5566d272a55acd LS cord-257258-hu9oxea1 5 2 doc_id doc_id CD cord-257258-hu9oxea1 5 3 : : : cord-257258-hu9oxea1 6 1 257258 257258 CD cord-257258-hu9oxea1 6 2 cord_uid cord_uid NNS cord-257258-hu9oxea1 6 3 : : : cord-257258-hu9oxea1 6 4 hu9oxea1 hu9oxea1 NNP cord-257258-hu9oxea1 7 1 What what WP cord-257258-hu9oxea1 7 2 are be VBP cord-257258-hu9oxea1 7 3 the the DT cord-257258-hu9oxea1 7 4 prospects prospect NNS cord-257258-hu9oxea1 7 5 for for IN cord-257258-hu9oxea1 7 6 dealing deal VBG cord-257258-hu9oxea1 7 7 with with IN cord-257258-hu9oxea1 7 8 COVID‐19 COVID‐19 NNP cord-257258-hu9oxea1 7 9 more more RBR cord-257258-hu9oxea1 7 10 effectively effectively RB cord-257258-hu9oxea1 7 11 in in IN cord-257258-hu9oxea1 7 12 the the DT cord-257258-hu9oxea1 7 13 future future NN cord-257258-hu9oxea1 7 14 ? ? . cord-257258-hu9oxea1 8 1 This this DT cord-257258-hu9oxea1 8 2 editorial editorial NN cord-257258-hu9oxea1 8 3 addresses address VBZ cord-257258-hu9oxea1 8 4 the the DT cord-257258-hu9oxea1 8 5 question question NN cord-257258-hu9oxea1 8 6 from from IN cord-257258-hu9oxea1 8 7 the the DT cord-257258-hu9oxea1 8 8 perspective perspective NN cord-257258-hu9oxea1 8 9 of of IN cord-257258-hu9oxea1 8 10 long‐term long‐term NNP cord-257258-hu9oxea1 8 11 control control NN cord-257258-hu9oxea1 8 12 of of IN cord-257258-hu9oxea1 8 13 coronavirus coronavirus NN cord-257258-hu9oxea1 8 14 infection infection NN cord-257258-hu9oxea1 8 15 . . . cord-257258-hu9oxea1 9 1 The the DT cord-257258-hu9oxea1 9 2 U.S. U.S. NNP cord-257258-hu9oxea1 9 3 health health NN cord-257258-hu9oxea1 9 4 system system NN cord-257258-hu9oxea1 9 5 and and CC cord-257258-hu9oxea1 9 6 governmental governmental JJ cord-257258-hu9oxea1 9 7 structures structure NNS cord-257258-hu9oxea1 9 8 are be VBP cord-257258-hu9oxea1 9 9 stressed stress VBN cord-257258-hu9oxea1 9 10 to to IN cord-257258-hu9oxea1 9 11 their -PRON- PRP$ cord-257258-hu9oxea1 9 12 limit limit NN cord-257258-hu9oxea1 9 13 , , , cord-257258-hu9oxea1 9 14 trying try VBG cord-257258-hu9oxea1 9 15 to to TO cord-257258-hu9oxea1 9 16 cope cope VB cord-257258-hu9oxea1 9 17 with with IN cord-257258-hu9oxea1 9 18 the the DT cord-257258-hu9oxea1 9 19 devastating devastating JJ cord-257258-hu9oxea1 9 20 effects effect NNS cord-257258-hu9oxea1 9 21 of of IN cord-257258-hu9oxea1 9 22 COVID-19 covid-19 NN cord-257258-hu9oxea1 9 23 on on IN cord-257258-hu9oxea1 9 24 patients patient NNS cord-257258-hu9oxea1 9 25 , , , cord-257258-hu9oxea1 9 26 on on IN cord-257258-hu9oxea1 9 27 our -PRON- PRP$ cord-257258-hu9oxea1 9 28 community community NN cord-257258-hu9oxea1 9 29 and and CC cord-257258-hu9oxea1 9 30 family family NN cord-257258-hu9oxea1 9 31 relationships relationship NNS cord-257258-hu9oxea1 9 32 , , , cord-257258-hu9oxea1 9 33 and and CC cord-257258-hu9oxea1 9 34 on on IN cord-257258-hu9oxea1 9 35 our -PRON- PRP$ cord-257258-hu9oxea1 9 36 national national JJ cord-257258-hu9oxea1 9 37 economy economy NN cord-257258-hu9oxea1 9 38 . . . cord-257258-hu9oxea1 10 1 In in IN cord-257258-hu9oxea1 10 2 the the DT cord-257258-hu9oxea1 10 3 absence absence NN cord-257258-hu9oxea1 10 4 of of IN cord-257258-hu9oxea1 10 5 a a DT cord-257258-hu9oxea1 10 6 vaccine vaccine NN cord-257258-hu9oxea1 10 7 or or CC cord-257258-hu9oxea1 10 8 effective effective JJ cord-257258-hu9oxea1 10 9 antivirals antiviral NNS cord-257258-hu9oxea1 10 10 , , , cord-257258-hu9oxea1 10 11 social social JJ cord-257258-hu9oxea1 10 12 distancing distancing NN cord-257258-hu9oxea1 10 13 is be VBZ cord-257258-hu9oxea1 10 14 currently currently RB cord-257258-hu9oxea1 10 15 the the DT cord-257258-hu9oxea1 10 16 primary primary JJ cord-257258-hu9oxea1 10 17 public public JJ cord-257258-hu9oxea1 10 18 health health NN cord-257258-hu9oxea1 10 19 strategy strategy NN cord-257258-hu9oxea1 10 20 for for IN cord-257258-hu9oxea1 10 21 containing contain VBG cord-257258-hu9oxea1 10 22 the the DT cord-257258-hu9oxea1 10 23 epidemic epidemic NN cord-257258-hu9oxea1 10 24 and and CC cord-257258-hu9oxea1 10 25 has have VBZ cord-257258-hu9oxea1 10 26 been be VBN cord-257258-hu9oxea1 10 27 successful successful JJ cord-257258-hu9oxea1 10 28 in in IN cord-257258-hu9oxea1 10 29 South South NNP cord-257258-hu9oxea1 10 30 Korea Korea NNP cord-257258-hu9oxea1 10 31 and and CC cord-257258-hu9oxea1 10 32 China China NNP cord-257258-hu9oxea1 10 33 , , , cord-257258-hu9oxea1 10 34 where where WRB cord-257258-hu9oxea1 10 35 it -PRON- PRP cord-257258-hu9oxea1 10 36 was be VBD cord-257258-hu9oxea1 10 37 stringently stringently RB cord-257258-hu9oxea1 10 38 employed employ VBN cord-257258-hu9oxea1 10 39 . . . cord-257258-hu9oxea1 11 1 In in IN cord-257258-hu9oxea1 11 2 the the DT cord-257258-hu9oxea1 11 3 U.S. U.S. NNP cord-257258-hu9oxea1 11 4 , , , cord-257258-hu9oxea1 11 5 it -PRON- PRP cord-257258-hu9oxea1 11 6 has have VBZ cord-257258-hu9oxea1 11 7 been be VBN cord-257258-hu9oxea1 11 8 applied apply VBN cord-257258-hu9oxea1 11 9 too too RB cord-257258-hu9oxea1 11 10 late late RB cord-257258-hu9oxea1 11 11 and and CC cord-257258-hu9oxea1 11 12 in in IN cord-257258-hu9oxea1 11 13 patchwork patchwork JJ cord-257258-hu9oxea1 11 14 fashion fashion NN cord-257258-hu9oxea1 11 15 on on IN cord-257258-hu9oxea1 11 16 a a DT cord-257258-hu9oxea1 11 17 national national JJ cord-257258-hu9oxea1 11 18 level level NN cord-257258-hu9oxea1 11 19 , , , cord-257258-hu9oxea1 11 20 allowing allow VBG cord-257258-hu9oxea1 11 21 the the DT cord-257258-hu9oxea1 11 22 virus virus NN cord-257258-hu9oxea1 11 23 to to TO cord-257258-hu9oxea1 11 24 spread spread VB cord-257258-hu9oxea1 11 25 broadly broadly RB cord-257258-hu9oxea1 11 26 . . . cord-257258-hu9oxea1 12 1 Home home NN cord-257258-hu9oxea1 12 2 isolation isolation NN cord-257258-hu9oxea1 12 3 and and CC cord-257258-hu9oxea1 12 4 social social JJ cord-257258-hu9oxea1 12 5 distancing distancing NN cord-257258-hu9oxea1 12 6 measures measure NNS cord-257258-hu9oxea1 12 7 inevitably inevitably RB cord-257258-hu9oxea1 12 8 impede impede VBP cord-257258-hu9oxea1 12 9 our -PRON- PRP$ cord-257258-hu9oxea1 12 10 ability ability NN cord-257258-hu9oxea1 12 11 as as IN cord-257258-hu9oxea1 12 12 physicians physician NNS cord-257258-hu9oxea1 12 13 to to TO cord-257258-hu9oxea1 12 14 care care VB cord-257258-hu9oxea1 12 15 for for IN cord-257258-hu9oxea1 12 16 patients patient NNS cord-257258-hu9oxea1 12 17 with with IN cord-257258-hu9oxea1 12 18 non non JJ cord-257258-hu9oxea1 12 19 - - JJ cord-257258-hu9oxea1 12 20 COVID-19 covid-19 JJ cord-257258-hu9oxea1 12 21 illness illness NN cord-257258-hu9oxea1 12 22 . . . cord-257258-hu9oxea1 13 1 There there EX cord-257258-hu9oxea1 13 2 is be VBZ cord-257258-hu9oxea1 13 3 a a DT cord-257258-hu9oxea1 13 4 very very RB cord-257258-hu9oxea1 13 5 real real JJ cord-257258-hu9oxea1 13 6 prospect prospect NN cord-257258-hu9oxea1 13 7 of of IN cord-257258-hu9oxea1 13 8 COVID-19 covid-19 JJ cord-257258-hu9oxea1 13 9 recurring recur VBG cord-257258-hu9oxea1 13 10 in in IN cord-257258-hu9oxea1 13 11 epidemic epidemic NN cord-257258-hu9oxea1 13 12 scale scale NN cord-257258-hu9oxea1 13 13 among among IN cord-257258-hu9oxea1 13 14 those those DT cord-257258-hu9oxea1 13 15 not not RB cord-257258-hu9oxea1 13 16 immune immune JJ cord-257258-hu9oxea1 13 17 to to IN cord-257258-hu9oxea1 13 18 the the DT cord-257258-hu9oxea1 13 19 virus virus NN cord-257258-hu9oxea1 13 20 . . . cord-257258-hu9oxea1 14 1 What what WP cord-257258-hu9oxea1 14 2 are be VBP cord-257258-hu9oxea1 14 3 the the DT cord-257258-hu9oxea1 14 4 prospects prospect NNS cord-257258-hu9oxea1 14 5 for for IN cord-257258-hu9oxea1 14 6 dealing deal VBG cord-257258-hu9oxea1 14 7 with with IN cord-257258-hu9oxea1 14 8 this this DT cord-257258-hu9oxea1 14 9 virus virus NN cord-257258-hu9oxea1 14 10 more more RBR cord-257258-hu9oxea1 14 11 effectively effectively RB cord-257258-hu9oxea1 14 12 in in IN cord-257258-hu9oxea1 14 13 the the DT cord-257258-hu9oxea1 14 14 future future NN cord-257258-hu9oxea1 14 15 ? ? . cord-257258-hu9oxea1 15 1 We -PRON- PRP cord-257258-hu9oxea1 15 2 will will MD cord-257258-hu9oxea1 15 3 need need VB cord-257258-hu9oxea1 15 4 a a DT cord-257258-hu9oxea1 15 5 more more RBR cord-257258-hu9oxea1 15 6 timely timely JJ cord-257258-hu9oxea1 15 7 and and CC cord-257258-hu9oxea1 15 8 comprehensive comprehensive JJ cord-257258-hu9oxea1 15 9 response response NN cord-257258-hu9oxea1 15 10 by by IN cord-257258-hu9oxea1 15 11 the the DT cord-257258-hu9oxea1 15 12 federal federal JJ cord-257258-hu9oxea1 15 13 government government NN cord-257258-hu9oxea1 15 14 , , , cord-257258-hu9oxea1 15 15 rather rather RB cord-257258-hu9oxea1 15 16 than than IN cord-257258-hu9oxea1 15 17 the the DT cord-257258-hu9oxea1 15 18 weeks week NNS cord-257258-hu9oxea1 15 19 of of IN cord-257258-hu9oxea1 15 20 denial denial NN cord-257258-hu9oxea1 15 21 , , , cord-257258-hu9oxea1 15 22 delay delay NN cord-257258-hu9oxea1 15 23 , , , cord-257258-hu9oxea1 15 24 and and CC cord-257258-hu9oxea1 15 25 incompetence incompetence NN cord-257258-hu9oxea1 15 26 in in IN cord-257258-hu9oxea1 15 27 developing develop VBG cord-257258-hu9oxea1 15 28 tests test NNS cord-257258-hu9oxea1 15 29 and and CC cord-257258-hu9oxea1 15 30 enacting enact VBG cord-257258-hu9oxea1 15 31 public public JJ cord-257258-hu9oxea1 15 32 health health NN cord-257258-hu9oxea1 15 33 measures measure NNS cord-257258-hu9oxea1 15 34 . . . cord-257258-hu9oxea1 16 1 We -PRON- PRP cord-257258-hu9oxea1 16 2 will will MD cord-257258-hu9oxea1 16 3 need need VB cord-257258-hu9oxea1 16 4 international international JJ cord-257258-hu9oxea1 16 5 cooperation cooperation NN cord-257258-hu9oxea1 16 6 in in IN cord-257258-hu9oxea1 16 7 sharing share VBG cord-257258-hu9oxea1 16 8 information information NN cord-257258-hu9oxea1 16 9 , , , cord-257258-hu9oxea1 16 10 testing testing NN cord-257258-hu9oxea1 16 11 and and CC cord-257258-hu9oxea1 16 12 mitigation mitigation NN cord-257258-hu9oxea1 16 13 strategies strategy NNS cord-257258-hu9oxea1 16 14 , , , cord-257258-hu9oxea1 16 15 and and CC cord-257258-hu9oxea1 16 16 medical medical JJ cord-257258-hu9oxea1 16 17 resources resource NNS cord-257258-hu9oxea1 16 18 , , , cord-257258-hu9oxea1 16 19 which which WDT cord-257258-hu9oxea1 16 20 are be VBP cord-257258-hu9oxea1 16 21 produced produce VBN cord-257258-hu9oxea1 16 22 and and CC cord-257258-hu9oxea1 16 23 sold sell VBN cord-257258-hu9oxea1 16 24 on on IN cord-257258-hu9oxea1 16 25 the the DT cord-257258-hu9oxea1 16 26 international international JJ cord-257258-hu9oxea1 16 27 market market NN cord-257258-hu9oxea1 16 28 . . . cord-257258-hu9oxea1 17 1 And and CC cord-257258-hu9oxea1 17 2 we -PRON- PRP cord-257258-hu9oxea1 17 3 will will MD cord-257258-hu9oxea1 17 4 need need VB cord-257258-hu9oxea1 17 5 drugs drug NNS cord-257258-hu9oxea1 17 6 and and CC cord-257258-hu9oxea1 17 7 vaccines vaccine NNS cord-257258-hu9oxea1 17 8 . . . cord-257258-hu9oxea1 18 1 The the DT cord-257258-hu9oxea1 18 2 first first JJ cord-257258-hu9oxea1 18 3 thought thought NN cord-257258-hu9oxea1 18 4 in in IN cord-257258-hu9oxea1 18 5 preventing prevent VBG cord-257258-hu9oxea1 18 6 a a DT cord-257258-hu9oxea1 18 7 recurrence recurrence NN cord-257258-hu9oxea1 18 8 of of IN cord-257258-hu9oxea1 18 9 COVID-19 covid-19 NN cord-257258-hu9oxea1 18 10 is be VBZ cord-257258-hu9oxea1 18 11 to to TO cord-257258-hu9oxea1 18 12 develop develop VB cord-257258-hu9oxea1 18 13 , , , cord-257258-hu9oxea1 18 14 test test VB cord-257258-hu9oxea1 18 15 , , , cord-257258-hu9oxea1 18 16 and and CC cord-257258-hu9oxea1 18 17 broadly broadly RB cord-257258-hu9oxea1 18 18 administer administer VB cord-257258-hu9oxea1 18 19 an an DT cord-257258-hu9oxea1 18 20 effective effective JJ cord-257258-hu9oxea1 18 21 vaccine vaccine NN cord-257258-hu9oxea1 18 22 [ [ -LRB- cord-257258-hu9oxea1 18 23 1 1 CD cord-257258-hu9oxea1 18 24 ] ] -RRB- cord-257258-hu9oxea1 18 25 . . . cord-257258-hu9oxea1 19 1 The the DT cord-257258-hu9oxea1 19 2 process process NN cord-257258-hu9oxea1 19 3 of of IN cord-257258-hu9oxea1 19 4 vaccine vaccine NN cord-257258-hu9oxea1 19 5 development development NN cord-257258-hu9oxea1 19 6 will will MD cord-257258-hu9oxea1 19 7 require require VB cord-257258-hu9oxea1 19 8 large large JJ cord-257258-hu9oxea1 19 9 - - HYPH cord-257258-hu9oxea1 19 10 scale scale NN cord-257258-hu9oxea1 19 11 testing testing NN cord-257258-hu9oxea1 19 12 in in IN cord-257258-hu9oxea1 19 13 virus virus NN cord-257258-hu9oxea1 19 14 - - HYPH cord-257258-hu9oxea1 19 15 naïve naïve JJ cord-257258-hu9oxea1 19 16 populations population NNS cord-257258-hu9oxea1 19 17 , , , cord-257258-hu9oxea1 19 18 will will MD cord-257258-hu9oxea1 19 19 likely likely RB cord-257258-hu9oxea1 19 20 take take VB cord-257258-hu9oxea1 19 21 more more JJR cord-257258-hu9oxea1 19 22 than than IN cord-257258-hu9oxea1 19 23 one one CD cord-257258-hu9oxea1 19 24 year year NN cord-257258-hu9oxea1 19 25 , , , cord-257258-hu9oxea1 19 26 and and CC cord-257258-hu9oxea1 19 27 will will MD cord-257258-hu9oxea1 19 28 require require VB cord-257258-hu9oxea1 19 29 worldwide worldwide JJ cord-257258-hu9oxea1 19 30 cooperation cooperation NN cord-257258-hu9oxea1 19 31 [ [ -LRB- cord-257258-hu9oxea1 19 32 2 2 CD cord-257258-hu9oxea1 19 33 ] ] -RRB- cord-257258-hu9oxea1 19 34 . . . cord-257258-hu9oxea1 20 1 It -PRON- PRP cord-257258-hu9oxea1 20 2 is be VBZ cord-257258-hu9oxea1 20 3 not not RB cord-257258-hu9oxea1 20 4 sufficient sufficient JJ cord-257258-hu9oxea1 20 5 to to TO cord-257258-hu9oxea1 20 6 stop stop VB cord-257258-hu9oxea1 20 7 an an DT cord-257258-hu9oxea1 20 8 epidemic epidemic NN cord-257258-hu9oxea1 20 9 in in IN cord-257258-hu9oxea1 20 10 one one CD cord-257258-hu9oxea1 20 11 country country NN cord-257258-hu9oxea1 20 12 , , , cord-257258-hu9oxea1 20 13 given give VBN cord-257258-hu9oxea1 20 14 the the DT cord-257258-hu9oxea1 20 15 level level NN cord-257258-hu9oxea1 20 16 of of IN cord-257258-hu9oxea1 20 17 international international JJ cord-257258-hu9oxea1 20 18 travel travel NN cord-257258-hu9oxea1 20 19 and and CC cord-257258-hu9oxea1 20 20 commerce commerce NN cord-257258-hu9oxea1 20 21 . . . cord-257258-hu9oxea1 21 1 That that DT cord-257258-hu9oxea1 21 2 cooperation cooperation NN cord-257258-hu9oxea1 21 3 must must MD cord-257258-hu9oxea1 21 4 include include VB cord-257258-hu9oxea1 21 5 China China NNP cord-257258-hu9oxea1 21 6 , , , cord-257258-hu9oxea1 21 7 which which WDT cord-257258-hu9oxea1 21 8 has have VBZ cord-257258-hu9oxea1 21 9 been be VBN cord-257258-hu9oxea1 21 10 the the DT cord-257258-hu9oxea1 21 11 source source NN cord-257258-hu9oxea1 21 12 of of IN cord-257258-hu9oxea1 21 13 several several JJ cord-257258-hu9oxea1 21 14 coronavirus coronavirus NN cord-257258-hu9oxea1 21 15 outbreaks outbreak NNS cord-257258-hu9oxea1 21 16 and and CC cord-257258-hu9oxea1 21 17 which which WDT cord-257258-hu9oxea1 21 18 has have VBZ cord-257258-hu9oxea1 21 19 the the DT cord-257258-hu9oxea1 21 20 ability ability NN cord-257258-hu9oxea1 21 21 to to TO cord-257258-hu9oxea1 21 22 develop develop VB cord-257258-hu9oxea1 21 23 and and CC cord-257258-hu9oxea1 21 24 produce produce VB cord-257258-hu9oxea1 21 25 vaccines vaccine NNS cord-257258-hu9oxea1 21 26 on on IN cord-257258-hu9oxea1 21 27 a a DT cord-257258-hu9oxea1 21 28 massive massive JJ cord-257258-hu9oxea1 21 29 scale scale NN cord-257258-hu9oxea1 21 30 . . . cord-257258-hu9oxea1 22 1 We -PRON- PRP cord-257258-hu9oxea1 22 2 realized realize VBD cord-257258-hu9oxea1 22 3 as as IN cord-257258-hu9oxea1 22 4 a a DT cord-257258-hu9oxea1 22 5 result result NN cord-257258-hu9oxea1 22 6 of of IN cord-257258-hu9oxea1 22 7 our -PRON- PRP$ cord-257258-hu9oxea1 22 8 current current JJ cord-257258-hu9oxea1 22 9 experience experience NN cord-257258-hu9oxea1 22 10 that that IN cord-257258-hu9oxea1 22 11 China China NNP cord-257258-hu9oxea1 22 12 is be VBZ cord-257258-hu9oxea1 22 13 currently currently RB cord-257258-hu9oxea1 22 14 the the DT cord-257258-hu9oxea1 22 15 major major JJ cord-257258-hu9oxea1 22 16 producer producer NN cord-257258-hu9oxea1 22 17 of of IN cord-257258-hu9oxea1 22 18 the the DT cord-257258-hu9oxea1 22 19 world world NN cord-257258-hu9oxea1 22 20 's 's POS cord-257258-hu9oxea1 22 21 medical medical JJ cord-257258-hu9oxea1 22 22 equipment equipment NN cord-257258-hu9oxea1 22 23 , , , cord-257258-hu9oxea1 22 24 including include VBG cord-257258-hu9oxea1 22 25 masks mask NNS cord-257258-hu9oxea1 22 26 , , , cord-257258-hu9oxea1 22 27 protective protective JJ cord-257258-hu9oxea1 22 28 gowns gown NNS cord-257258-hu9oxea1 22 29 , , , cord-257258-hu9oxea1 22 30 and and CC cord-257258-hu9oxea1 22 31 ventilators ventilator NNS cord-257258-hu9oxea1 22 32 , , , cord-257258-hu9oxea1 22 33 as as RB cord-257258-hu9oxea1 22 34 well well RB cord-257258-hu9oxea1 22 35 as as IN cord-257258-hu9oxea1 22 36 the the DT cord-257258-hu9oxea1 22 37 chemical chemical JJ cord-257258-hu9oxea1 22 38 ingredients ingredient NNS cord-257258-hu9oxea1 22 39 in in IN cord-257258-hu9oxea1 22 40 most most JJS cord-257258-hu9oxea1 22 41 of of IN cord-257258-hu9oxea1 22 42 our -PRON- PRP$ cord-257258-hu9oxea1 22 43 medications medication NNS cord-257258-hu9oxea1 22 44 . . . cord-257258-hu9oxea1 23 1 A a DT cord-257258-hu9oxea1 23 2 collaborative collaborative JJ cord-257258-hu9oxea1 23 3 relationship relationship NN cord-257258-hu9oxea1 23 4 with with IN cord-257258-hu9oxea1 23 5 health health NN cord-257258-hu9oxea1 23 6 authorities authority NNS cord-257258-hu9oxea1 23 7 in in IN cord-257258-hu9oxea1 23 8 China China NNP cord-257258-hu9oxea1 23 9 will will MD cord-257258-hu9oxea1 23 10 be be VB cord-257258-hu9oxea1 23 11 crucial crucial JJ cord-257258-hu9oxea1 23 12 to to IN cord-257258-hu9oxea1 23 13 our -PRON- PRP$ cord-257258-hu9oxea1 23 14 ability ability NN cord-257258-hu9oxea1 23 15 to to TO cord-257258-hu9oxea1 23 16 cope cope VB cord-257258-hu9oxea1 23 17 with with IN cord-257258-hu9oxea1 23 18 future future JJ cord-257258-hu9oxea1 23 19 epidemics epidemic NNS cord-257258-hu9oxea1 23 20 . . . cord-257258-hu9oxea1 24 1 Regarding regard VBG cord-257258-hu9oxea1 24 2 the the DT cord-257258-hu9oxea1 24 3 chances chance NNS cord-257258-hu9oxea1 24 4 of of IN cord-257258-hu9oxea1 24 5 creating create VBG cord-257258-hu9oxea1 24 6 an an DT cord-257258-hu9oxea1 24 7 effective effective JJ cord-257258-hu9oxea1 24 8 vaccine vaccine NN cord-257258-hu9oxea1 24 9 against against IN cord-257258-hu9oxea1 24 10 SARS SARS NNP cord-257258-hu9oxea1 24 11 - - HYPH cord-257258-hu9oxea1 24 12 CoV-2 CoV-2 NNP cord-257258-hu9oxea1 24 13 infection infection NN cord-257258-hu9oxea1 24 14 , , , cord-257258-hu9oxea1 24 15 in in IN cord-257258-hu9oxea1 24 16 the the DT cord-257258-hu9oxea1 24 17 U.S. U.S. NNP cord-257258-hu9oxea1 24 18 the the DT cord-257258-hu9oxea1 24 19 Biomedical Biomedical NNP cord-257258-hu9oxea1 24 20 Advanced Advanced NNP cord-257258-hu9oxea1 24 21 Research Research NNP cord-257258-hu9oxea1 24 22 and and CC cord-257258-hu9oxea1 24 23 Development Development NNP cord-257258-hu9oxea1 24 24 Authority Authority NNP cord-257258-hu9oxea1 24 25 ( ( -LRB- cord-257258-hu9oxea1 24 26 BARDA BARDA NNP cord-257258-hu9oxea1 24 27 ) ) -RRB- cord-257258-hu9oxea1 24 28 of of IN cord-257258-hu9oxea1 24 29 the the DT cord-257258-hu9oxea1 24 30 Department Department NNP cord-257258-hu9oxea1 24 31 of of IN cord-257258-hu9oxea1 24 32 Health Health NNP cord-257258-hu9oxea1 24 33 and and CC cord-257258-hu9oxea1 24 34 Human Human NNP cord-257258-hu9oxea1 24 35 Services Services NNPS cord-257258-hu9oxea1 24 36 is be VBZ cord-257258-hu9oxea1 24 37 devoting devote VBG cord-257258-hu9oxea1 24 38 significant significant JJ cord-257258-hu9oxea1 24 39 support support NN cord-257258-hu9oxea1 24 40 for for IN cord-257258-hu9oxea1 24 41 two two CD cord-257258-hu9oxea1 24 42 currently currently RB cord-257258-hu9oxea1 24 43 approved approve VBN cord-257258-hu9oxea1 24 44 trials trial NNS cord-257258-hu9oxea1 24 45 : : : cord-257258-hu9oxea1 24 46 a a DT cord-257258-hu9oxea1 24 47 lipid lipid NN cord-257258-hu9oxea1 24 48 nanoparticle nanoparticle NN cord-257258-hu9oxea1 24 49 vaccine vaccine NN cord-257258-hu9oxea1 24 50 that that WDT cord-257258-hu9oxea1 24 51 contains contain VBZ cord-257258-hu9oxea1 24 52 mRNAs mRNAs NNPS cord-257258-hu9oxea1 24 53 directing direct VBG cord-257258-hu9oxea1 24 54 the the DT cord-257258-hu9oxea1 24 55 synthesis synthesis NN cord-257258-hu9oxea1 24 56 of of IN cord-257258-hu9oxea1 24 57 the the DT cord-257258-hu9oxea1 24 58 SARS SARS NNP cord-257258-hu9oxea1 24 59 - - HYPH cord-257258-hu9oxea1 24 60 CoV-2 CoV-2 NNP cord-257258-hu9oxea1 24 61 spike spike NN cord-257258-hu9oxea1 24 62 protein protein NN cord-257258-hu9oxea1 24 63 ( ( -LRB- cord-257258-hu9oxea1 24 64 Moderna Moderna NNP cord-257258-hu9oxea1 24 65 ) ) -RRB- cord-257258-hu9oxea1 24 66 and and CC cord-257258-hu9oxea1 24 67 an an DT cord-257258-hu9oxea1 24 68 adenovirus adenovirus NN cord-257258-hu9oxea1 24 69 construct construct NN cord-257258-hu9oxea1 24 70 of of IN cord-257258-hu9oxea1 24 71 virus virus NN cord-257258-hu9oxea1 24 72 material material NN cord-257258-hu9oxea1 24 73 co co NN cord-257258-hu9oxea1 24 74 - - VBN cord-257258-hu9oxea1 24 75 supported support VBN cord-257258-hu9oxea1 24 76 by by IN cord-257258-hu9oxea1 24 77 Johnson Johnson NNP cord-257258-hu9oxea1 24 78 & & CC cord-257258-hu9oxea1 24 79 Johnson Johnson NNP cord-257258-hu9oxea1 24 80 [ [ -LRB- cord-257258-hu9oxea1 24 81 1 1 CD cord-257258-hu9oxea1 24 82 ] ] -RRB- cord-257258-hu9oxea1 24 83 . . . cord-257258-hu9oxea1 25 1 The the DT cord-257258-hu9oxea1 25 2 Wellcome Wellcome NNP cord-257258-hu9oxea1 25 3 Trust Trust NNP cord-257258-hu9oxea1 25 4 and and CC cord-257258-hu9oxea1 25 5 Gates Gates NNP cord-257258-hu9oxea1 25 6 Foundation Foundation NNP cord-257258-hu9oxea1 25 7 have have VBP cord-257258-hu9oxea1 25 8 implemented implement VBN cord-257258-hu9oxea1 25 9 an an DT cord-257258-hu9oxea1 25 10 international international JJ cord-257258-hu9oxea1 25 11 effort effort NN cord-257258-hu9oxea1 25 12 , , , cord-257258-hu9oxea1 25 13 the the DT cord-257258-hu9oxea1 25 14 Coalition Coalition NNP cord-257258-hu9oxea1 25 15 for for IN cord-257258-hu9oxea1 25 16 Epidemic Epidemic NNP cord-257258-hu9oxea1 25 17 Preparedness Preparedness NNP cord-257258-hu9oxea1 25 18 Innovation Innovation NNP cord-257258-hu9oxea1 25 19 ( ( -LRB- cord-257258-hu9oxea1 25 20 CEPI CEPI NNP cord-257258-hu9oxea1 25 21 ) ) -RRB- cord-257258-hu9oxea1 25 22 , , , cord-257258-hu9oxea1 25 23 to to TO cord-257258-hu9oxea1 25 24 select select VB cord-257258-hu9oxea1 25 25 and and CC cord-257258-hu9oxea1 25 26 promote promote VB cord-257258-hu9oxea1 25 27 the the DT cord-257258-hu9oxea1 25 28 development development NN cord-257258-hu9oxea1 25 29 of of IN cord-257258-hu9oxea1 25 30 three three CD cord-257258-hu9oxea1 25 31 promising promising JJ cord-257258-hu9oxea1 25 32 vaccines vaccine NNS cord-257258-hu9oxea1 25 33 , , , cord-257258-hu9oxea1 25 34 with with IN cord-257258-hu9oxea1 25 35 the the DT cord-257258-hu9oxea1 25 36 intent intent NN cord-257258-hu9oxea1 25 37 to to TO cord-257258-hu9oxea1 25 38 achieve achieve VB cord-257258-hu9oxea1 25 39 worldwide worldwide JJ cord-257258-hu9oxea1 25 40 distribution distribution NN cord-257258-hu9oxea1 25 41 of of IN cord-257258-hu9oxea1 25 42 an an DT cord-257258-hu9oxea1 25 43 effective effective JJ cord-257258-hu9oxea1 25 44 agent agent NN cord-257258-hu9oxea1 25 45 in in IN cord-257258-hu9oxea1 25 46 the the DT cord-257258-hu9oxea1 25 47 next next JJ cord-257258-hu9oxea1 25 48 year year NN cord-257258-hu9oxea1 25 49 [ [ -LRB- cord-257258-hu9oxea1 25 50 3 3 CD cord-257258-hu9oxea1 25 51 ] ] -RRB- cord-257258-hu9oxea1 25 52 . . . cord-257258-hu9oxea1 26 1 Multiple multiple JJ cord-257258-hu9oxea1 26 2 other other JJ cord-257258-hu9oxea1 26 3 approaches approach NNS cord-257258-hu9oxea1 26 4 to to IN cord-257258-hu9oxea1 26 5 vaccine vaccine NN cord-257258-hu9oxea1 26 6 development development NN cord-257258-hu9oxea1 26 7 are be VBP cord-257258-hu9oxea1 26 8 in in IN cord-257258-hu9oxea1 26 9 play play NN cord-257258-hu9oxea1 26 10 , , , cord-257258-hu9oxea1 26 11 including include VBG cord-257258-hu9oxea1 26 12 the the DT cord-257258-hu9oxea1 26 13 use use NN cord-257258-hu9oxea1 26 14 of of IN cord-257258-hu9oxea1 26 15 DNA DNA NNP cord-257258-hu9oxea1 26 16 and and CC cord-257258-hu9oxea1 26 17 mRNA mrna NN cord-257258-hu9oxea1 26 18 vectors vector NNS cord-257258-hu9oxea1 26 19 , , , cord-257258-hu9oxea1 26 20 as as RB cord-257258-hu9oxea1 26 21 well well RB cord-257258-hu9oxea1 26 22 as as IN cord-257258-hu9oxea1 26 23 viral viral JJ cord-257258-hu9oxea1 26 24 proteins protein NNS cord-257258-hu9oxea1 26 25 and and CC cord-257258-hu9oxea1 26 26 peptide peptide NN cord-257258-hu9oxea1 26 27 epitopes epitope NNS cord-257258-hu9oxea1 26 28 , , , cord-257258-hu9oxea1 26 29 delivered deliver VBN cord-257258-hu9oxea1 26 30 in in IN cord-257258-hu9oxea1 26 31 different different JJ cord-257258-hu9oxea1 26 32 formulations formulation NNS cord-257258-hu9oxea1 26 33 and and CC cord-257258-hu9oxea1 26 34 with with IN cord-257258-hu9oxea1 26 35 different different JJ cord-257258-hu9oxea1 26 36 adjuvants adjuvant NNS cord-257258-hu9oxea1 26 37 . . . cord-257258-hu9oxea1 27 1 Proving prove VBG cord-257258-hu9oxea1 27 2 efficacy efficacy NN cord-257258-hu9oxea1 27 3 and and CC cord-257258-hu9oxea1 27 4 safety safety NN cord-257258-hu9oxea1 27 5 in in IN cord-257258-hu9oxea1 27 6 large large JJ cord-257258-hu9oxea1 27 7 - - HYPH cord-257258-hu9oxea1 27 8 scale scale NN cord-257258-hu9oxea1 27 9 randomized randomized JJ cord-257258-hu9oxea1 27 10 trials trial NNS cord-257258-hu9oxea1 27 11 is be VBZ cord-257258-hu9oxea1 27 12 the the DT cord-257258-hu9oxea1 27 13 critical critical JJ cord-257258-hu9oxea1 27 14 step step NN cord-257258-hu9oxea1 27 15 that that WDT cord-257258-hu9oxea1 27 16 determines determine VBZ cord-257258-hu9oxea1 27 17 failure failure NN cord-257258-hu9oxea1 27 18 or or CC cord-257258-hu9oxea1 27 19 success success NN cord-257258-hu9oxea1 27 20 , , , cord-257258-hu9oxea1 27 21 and and CC cord-257258-hu9oxea1 27 22 all all DT cord-257258-hu9oxea1 27 23 of of IN cord-257258-hu9oxea1 27 24 this this DT cord-257258-hu9oxea1 27 25 will will MD cord-257258-hu9oxea1 27 26 take take VB cord-257258-hu9oxea1 27 27 many many JJ cord-257258-hu9oxea1 27 28 months month NNS cord-257258-hu9oxea1 27 29 , , , cord-257258-hu9oxea1 27 30 if if IN cord-257258-hu9oxea1 27 31 not not RB cord-257258-hu9oxea1 27 32 1 1 CD cord-257258-hu9oxea1 27 33 - - SYM cord-257258-hu9oxea1 27 34 2 2 CD cord-257258-hu9oxea1 27 35 years year NNS cord-257258-hu9oxea1 27 36 . . . cord-257258-hu9oxea1 28 1 While while IN cord-257258-hu9oxea1 28 2 vaccine vaccine NN cord-257258-hu9oxea1 28 3 development development NN cord-257258-hu9oxea1 28 4 has have VBZ cord-257258-hu9oxea1 28 5 an an DT cord-257258-hu9oxea1 28 6 obvious obvious JJ cord-257258-hu9oxea1 28 7 high high JJ cord-257258-hu9oxea1 28 8 priority priority NN cord-257258-hu9oxea1 28 9 , , , cord-257258-hu9oxea1 28 10 much much JJ cord-257258-hu9oxea1 28 11 attention attention NN cord-257258-hu9oxea1 28 12 has have VBZ cord-257258-hu9oxea1 28 13 also also RB cord-257258-hu9oxea1 28 14 been be VBN cord-257258-hu9oxea1 28 15 given give VBN cord-257258-hu9oxea1 28 16 in in IN cord-257258-hu9oxea1 28 17 the the DT cord-257258-hu9oxea1 28 18 press press NN cord-257258-hu9oxea1 28 19 and and CC cord-257258-hu9oxea1 28 20 in in IN cord-257258-hu9oxea1 28 21 discussions discussion NNS cord-257258-hu9oxea1 28 22 of of IN cord-257258-hu9oxea1 28 23 the the DT cord-257258-hu9oxea1 28 24 White White NNP cord-257258-hu9oxea1 28 25 House House NNP cord-257258-hu9oxea1 28 26 Task Task NNP cord-257258-hu9oxea1 28 27 Force Force NNP cord-257258-hu9oxea1 28 28 to to IN cord-257258-hu9oxea1 28 29 the the DT cord-257258-hu9oxea1 28 30 development development NN cord-257258-hu9oxea1 28 31 of of IN cord-257258-hu9oxea1 28 32 effective effective JJ cord-257258-hu9oxea1 28 33 antiviral antiviral JJ cord-257258-hu9oxea1 28 34 drugs drug NNS cord-257258-hu9oxea1 28 35 . . . cord-257258-hu9oxea1 29 1 Drugs drug NNS cord-257258-hu9oxea1 29 2 may may MD cord-257258-hu9oxea1 29 3 have have VB cord-257258-hu9oxea1 29 4 a a DT cord-257258-hu9oxea1 29 5 greater great JJR cord-257258-hu9oxea1 29 6 chance chance NN cord-257258-hu9oxea1 29 7 of of IN cord-257258-hu9oxea1 29 8 early early JJ cord-257258-hu9oxea1 29 9 success success NN cord-257258-hu9oxea1 29 10 . . . cord-257258-hu9oxea1 30 1 Thus thus RB cord-257258-hu9oxea1 30 2 far far RB cord-257258-hu9oxea1 30 3 , , , cord-257258-hu9oxea1 30 4 the the DT cord-257258-hu9oxea1 30 5 public public JJ cord-257258-hu9oxea1 30 6 discourse discourse NN cord-257258-hu9oxea1 30 7 has have VBZ cord-257258-hu9oxea1 30 8 generated generate VBN cord-257258-hu9oxea1 30 9 significant significant JJ cord-257258-hu9oxea1 30 10 confusion confusion NN cord-257258-hu9oxea1 30 11 and and CC cord-257258-hu9oxea1 30 12 misconception misconception NN cord-257258-hu9oxea1 30 13 . . . cord-257258-hu9oxea1 31 1 The the DT cord-257258-hu9oxea1 31 2 President President NNP cord-257258-hu9oxea1 31 3 has have VBZ cord-257258-hu9oxea1 31 4 touted tout VBN cord-257258-hu9oxea1 31 5 the the DT cord-257258-hu9oxea1 31 6 benefits benefit NNS cord-257258-hu9oxea1 31 7 of of IN cord-257258-hu9oxea1 31 8 hydroxychloroquine hydroxychloroquine NN cord-257258-hu9oxea1 31 9 ( ( -LRB- cord-257258-hu9oxea1 31 10 HQ HQ NNP cord-257258-hu9oxea1 31 11 ) ) -RRB- cord-257258-hu9oxea1 31 12 and and CC cord-257258-hu9oxea1 31 13 advocated advocate VBD cord-257258-hu9oxea1 31 14 its -PRON- PRP$ cord-257258-hu9oxea1 31 15 off off JJ cord-257258-hu9oxea1 31 16 - - HYPH cord-257258-hu9oxea1 31 17 label label NN cord-257258-hu9oxea1 31 18 use use NN cord-257258-hu9oxea1 31 19 , , , cord-257258-hu9oxea1 31 20 and and CC cord-257258-hu9oxea1 31 21 the the DT cord-257258-hu9oxea1 31 22 FDA FDA NNP cord-257258-hu9oxea1 31 23 has have VBZ cord-257258-hu9oxea1 31 24 surprisingly surprisingly RB cord-257258-hu9oxea1 31 25 endorsed endorse VBN cord-257258-hu9oxea1 31 26 his -PRON- PRP$ cord-257258-hu9oxea1 31 27 position position NN cord-257258-hu9oxea1 31 28 by by IN cord-257258-hu9oxea1 31 29 granting grant VBG cord-257258-hu9oxea1 31 30 an an DT cord-257258-hu9oxea1 31 31 emergency emergency NN cord-257258-hu9oxea1 31 32 approval approval NN cord-257258-hu9oxea1 31 33 for for IN cord-257258-hu9oxea1 31 34 COVID-19 covid-19 JJ cord-257258-hu9oxea1 31 35 patients patient NNS cord-257258-hu9oxea1 31 36 . . . cord-257258-hu9oxea1 32 1 The the DT cord-257258-hu9oxea1 32 2 laboratory laboratory NN cord-257258-hu9oxea1 32 3 evidence evidence NN cord-257258-hu9oxea1 32 4 that that IN cord-257258-hu9oxea1 32 5 HQ HQ NNP cord-257258-hu9oxea1 32 6 has have VBZ cord-257258-hu9oxea1 32 7 antiviral antiviral JJ cord-257258-hu9oxea1 32 8 effects effect NNS cord-257258-hu9oxea1 32 9 is be VBZ cord-257258-hu9oxea1 32 10 minimal minimal JJ cord-257258-hu9oxea1 32 11 . . . cord-257258-hu9oxea1 33 1 It -PRON- PRP cord-257258-hu9oxea1 33 2 suppresses suppress VBZ cord-257258-hu9oxea1 33 3 viral viral JJ cord-257258-hu9oxea1 33 4 replication replication NN cord-257258-hu9oxea1 33 5 only only RB cord-257258-hu9oxea1 33 6 at at IN cord-257258-hu9oxea1 33 7 very very RB cord-257258-hu9oxea1 33 8 high high JJ cord-257258-hu9oxea1 33 9 , , , cord-257258-hu9oxea1 33 10 nonpharmacological nonpharmacological JJ cord-257258-hu9oxea1 33 11 drug drug NN cord-257258-hu9oxea1 33 12 concentrations concentration NNS cord-257258-hu9oxea1 33 13 [ [ -LRB- cord-257258-hu9oxea1 33 14 4 4 CD cord-257258-hu9oxea1 33 15 ] ] -RRB- cord-257258-hu9oxea1 33 16 . . . cord-257258-hu9oxea1 34 1 The the DT cord-257258-hu9oxea1 34 2 clinical clinical JJ cord-257258-hu9oxea1 34 3 evidence evidence NN cord-257258-hu9oxea1 34 4 for for IN cord-257258-hu9oxea1 34 5 HQ HQ NNP cord-257258-hu9oxea1 34 6 efficacy efficacy NN cord-257258-hu9oxea1 34 7 comes come VBZ cord-257258-hu9oxea1 34 8 from from IN cord-257258-hu9oxea1 34 9 several several JJ cord-257258-hu9oxea1 34 10 conflicting conflict VBG cord-257258-hu9oxea1 34 11 reports report NNS cord-257258-hu9oxea1 34 12 from from IN cord-257258-hu9oxea1 34 13 China China NNP cord-257258-hu9oxea1 34 14 and and CC cord-257258-hu9oxea1 34 15 an an DT cord-257258-hu9oxea1 34 16 article article NN cord-257258-hu9oxea1 34 17 in in IN cord-257258-hu9oxea1 34 18 the the DT cord-257258-hu9oxea1 34 19 International International NNP cord-257258-hu9oxea1 34 20 Journal Journal NNP cord-257258-hu9oxea1 34 21 of of IN cord-257258-hu9oxea1 34 22 Antimicrobial Antimicrobial NNP cord-257258-hu9oxea1 34 23 Agents Agents NNPS cord-257258-hu9oxea1 34 24 [ [ -LRB- cord-257258-hu9oxea1 34 25 5 5 CD cord-257258-hu9oxea1 34 26 ] ] -RRB- cord-257258-hu9oxea1 34 27 , , , cord-257258-hu9oxea1 34 28 describing describe VBG cord-257258-hu9oxea1 34 29 a a DT cord-257258-hu9oxea1 34 30 poorly poorly RB cord-257258-hu9oxea1 34 31 performed perform VBN cord-257258-hu9oxea1 34 32 , , , cord-257258-hu9oxea1 34 33 uncontrolled uncontrolled JJ cord-257258-hu9oxea1 34 34 French french JJ cord-257258-hu9oxea1 34 35 study study NN cord-257258-hu9oxea1 34 36 , , , cord-257258-hu9oxea1 34 37 which which WDT cord-257258-hu9oxea1 34 38 has have VBZ cord-257258-hu9oxea1 34 39 been be VBN cord-257258-hu9oxea1 34 40 sharply sharply RB cord-257258-hu9oxea1 34 41 criticized criticize VBN cord-257258-hu9oxea1 34 42 by by IN cord-257258-hu9oxea1 34 43 the the DT cord-257258-hu9oxea1 34 44 journal journal NN cord-257258-hu9oxea1 34 45 sponsor sponsor NN cord-257258-hu9oxea1 34 46 , , , cord-257258-hu9oxea1 34 47 the the DT cord-257258-hu9oxea1 34 48 International International NNP cord-257258-hu9oxea1 34 49 Society Society NNP cord-257258-hu9oxea1 34 50 of of IN cord-257258-hu9oxea1 34 51 Antimicrobial Antimicrobial NNP cord-257258-hu9oxea1 34 52 Chemotherapy Chemotherapy NNP cord-257258-hu9oxea1 34 53 [ [ -LRB- cord-257258-hu9oxea1 34 54 5 5 CD cord-257258-hu9oxea1 34 55 ] ] -RRB- cord-257258-hu9oxea1 34 56 . . . cord-257258-hu9oxea1 35 1 The the DT cord-257258-hu9oxea1 35 2 President President NNP cord-257258-hu9oxea1 35 3 's 's POS cord-257258-hu9oxea1 35 4 endorsement endorsement NN cord-257258-hu9oxea1 35 5 of of IN cord-257258-hu9oxea1 35 6 hydroxychloroquine hydroxychloroquine NNP cord-257258-hu9oxea1 35 7 has have VBZ cord-257258-hu9oxea1 35 8 raised raise VBN cord-257258-hu9oxea1 35 9 concern concern NN cord-257258-hu9oxea1 35 10 among among IN cord-257258-hu9oxea1 35 11 scientists scientist NNS cord-257258-hu9oxea1 35 12 and and CC cord-257258-hu9oxea1 35 13 clinicians clinician NNS cord-257258-hu9oxea1 35 14 at at IN cord-257258-hu9oxea1 35 15 many many JJ cord-257258-hu9oxea1 35 16 levels level NNS cord-257258-hu9oxea1 35 17 , , , cord-257258-hu9oxea1 35 18 not not RB cord-257258-hu9oxea1 35 19 simply simply RB cord-257258-hu9oxea1 35 20 because because IN cord-257258-hu9oxea1 35 21 of of IN cord-257258-hu9oxea1 35 22 the the DT cord-257258-hu9oxea1 35 23 lack lack NN cord-257258-hu9oxea1 35 24 of of IN cord-257258-hu9oxea1 35 25 convincing convincing JJ cord-257258-hu9oxea1 35 26 data datum NNS cord-257258-hu9oxea1 35 27 to to TO cord-257258-hu9oxea1 35 28 support support VB cord-257258-hu9oxea1 35 29 its -PRON- PRP$ cord-257258-hu9oxea1 35 30 general general JJ cord-257258-hu9oxea1 35 31 use use NN cord-257258-hu9oxea1 35 32 against against IN cord-257258-hu9oxea1 35 33 COVID-19 COVID-19 NNP cord-257258-hu9oxea1 35 34 . . . cord-257258-hu9oxea1 36 1 The the DT cord-257258-hu9oxea1 36 2 wide wide RB cord-257258-hu9oxea1 36 3 - - HYPH cord-257258-hu9oxea1 36 4 ranging range VBG cord-257258-hu9oxea1 36 5 and and CC cord-257258-hu9oxea1 36 6 unsupervised unsupervised JJ cord-257258-hu9oxea1 36 7 deployment deployment NN cord-257258-hu9oxea1 36 8 of of IN cord-257258-hu9oxea1 36 9 this this DT cord-257258-hu9oxea1 36 10 medication medication NN cord-257258-hu9oxea1 36 11 will will MD cord-257258-hu9oxea1 36 12 undoubtedly undoubtedly RB cord-257258-hu9oxea1 36 13 affect affect VB cord-257258-hu9oxea1 36 14 the the DT cord-257258-hu9oxea1 36 15 ability ability NN cord-257258-hu9oxea1 36 16 of of IN cord-257258-hu9oxea1 36 17 serious serious JJ cord-257258-hu9oxea1 36 18 researchers researcher NNS cord-257258-hu9oxea1 36 19 to to TO cord-257258-hu9oxea1 36 20 recruit recruit VB cord-257258-hu9oxea1 36 21 patients patient NNS cord-257258-hu9oxea1 36 22 to to IN cord-257258-hu9oxea1 36 23 randomized randomized JJ cord-257258-hu9oxea1 36 24 trials trial NNS cord-257258-hu9oxea1 36 25 of of IN cord-257258-hu9oxea1 36 26 this this DT cord-257258-hu9oxea1 36 27 drug drug NN cord-257258-hu9oxea1 36 28 and and CC cord-257258-hu9oxea1 36 29 to to IN cord-257258-hu9oxea1 36 30 trials trial NNS cord-257258-hu9oxea1 36 31 of of IN cord-257258-hu9oxea1 36 32 other other JJ cord-257258-hu9oxea1 36 33 more more RBR cord-257258-hu9oxea1 36 34 promising promising JJ cord-257258-hu9oxea1 36 35 agents agent NNS cord-257258-hu9oxea1 36 36 . . . cord-257258-hu9oxea1 37 1 Despite despite IN cord-257258-hu9oxea1 37 2 the the DT cord-257258-hu9oxea1 37 3 assertion assertion NN cord-257258-hu9oxea1 37 4 , , , cord-257258-hu9oxea1 37 5 " " `` cord-257258-hu9oxea1 37 6 What what WP cord-257258-hu9oxea1 37 7 have have VBP cord-257258-hu9oxea1 37 8 you -PRON- PRP cord-257258-hu9oxea1 37 9 got get VBN cord-257258-hu9oxea1 37 10 to to TO cord-257258-hu9oxea1 37 11 lose lose VB cord-257258-hu9oxea1 37 12 ! ! . cord-257258-hu9oxea1 37 13 " " '' cord-257258-hu9oxea1 37 14 , , , cord-257258-hu9oxea1 37 15 there there EX cord-257258-hu9oxea1 37 16 are be VBP cord-257258-hu9oxea1 37 17 serious serious JJ cord-257258-hu9oxea1 37 18 risks risk NNS cord-257258-hu9oxea1 37 19 with with IN cord-257258-hu9oxea1 37 20 introducing introduce VBG cord-257258-hu9oxea1 37 21 any any DT cord-257258-hu9oxea1 37 22 new new JJ cord-257258-hu9oxea1 37 23 medication medication NN cord-257258-hu9oxea1 37 24 , , , cord-257258-hu9oxea1 37 25 particularly particularly RB cord-257258-hu9oxea1 37 26 in in IN cord-257258-hu9oxea1 37 27 severely severely RB cord-257258-hu9oxea1 37 28 ill ill JJ cord-257258-hu9oxea1 37 29 people people NNS cord-257258-hu9oxea1 37 30 . . . cord-257258-hu9oxea1 38 1 Hydroxychloroquine Hydroxychloroquine NNP cord-257258-hu9oxea1 38 2 is be VBZ cord-257258-hu9oxea1 38 3 not not RB cord-257258-hu9oxea1 38 4 an an DT cord-257258-hu9oxea1 38 5 innocuous innocuous JJ cord-257258-hu9oxea1 38 6 agent agent NN cord-257258-hu9oxea1 38 7 . . . cord-257258-hu9oxea1 39 1 It -PRON- PRP cord-257258-hu9oxea1 39 2 causes cause VBZ cord-257258-hu9oxea1 39 3 retinal retinal JJ cord-257258-hu9oxea1 39 4 degeneration degeneration NN cord-257258-hu9oxea1 39 5 , , , cord-257258-hu9oxea1 39 6 myopathy myopathy NN cord-257258-hu9oxea1 39 7 , , , cord-257258-hu9oxea1 39 8 QT qt NN cord-257258-hu9oxea1 39 9 interval interval NN cord-257258-hu9oxea1 39 10 elongation elongation NN cord-257258-hu9oxea1 39 11 , , , cord-257258-hu9oxea1 39 12 and and CC cord-257258-hu9oxea1 39 13 rarely rarely RB cord-257258-hu9oxea1 39 14 , , , cord-257258-hu9oxea1 39 15 ventricular ventricular JJ cord-257258-hu9oxea1 39 16 arrhythmias arrhythmias RB cord-257258-hu9oxea1 39 17 . . . cord-257258-hu9oxea1 40 1 It -PRON- PRP cord-257258-hu9oxea1 40 2 is be VBZ cord-257258-hu9oxea1 40 3 metabolized metabolize VBN cord-257258-hu9oxea1 40 4 by by IN cord-257258-hu9oxea1 40 5 hepatic hepatic JJ cord-257258-hu9oxea1 40 6 P450 p450 JJ cord-257258-hu9oxea1 40 7 enzymes enzyme NNS cord-257258-hu9oxea1 40 8 and and CC cord-257258-hu9oxea1 40 9 thus thus RB cord-257258-hu9oxea1 40 10 is be VBZ cord-257258-hu9oxea1 40 11 capable capable JJ cord-257258-hu9oxea1 40 12 of of IN cord-257258-hu9oxea1 40 13 significant significant JJ cord-257258-hu9oxea1 40 14 interaction interaction NN cord-257258-hu9oxea1 40 15 with with IN cord-257258-hu9oxea1 40 16 antibiotics antibiotic NNS cord-257258-hu9oxea1 40 17 , , , cord-257258-hu9oxea1 40 18 sedatives sedative NNS cord-257258-hu9oxea1 40 19 , , , cord-257258-hu9oxea1 40 20 and and CC cord-257258-hu9oxea1 40 21 other other JJ cord-257258-hu9oxea1 40 22 medications medication NNS cord-257258-hu9oxea1 40 23 commonly commonly RB cord-257258-hu9oxea1 40 24 used use VBN cord-257258-hu9oxea1 40 25 in in IN cord-257258-hu9oxea1 40 26 the the DT cord-257258-hu9oxea1 40 27 treatment treatment NN cord-257258-hu9oxea1 40 28 of of IN cord-257258-hu9oxea1 40 29 COVID-19 covid-19 JJ cord-257258-hu9oxea1 40 30 patients patient NNS cord-257258-hu9oxea1 40 31 . . . cord-257258-hu9oxea1 41 1 In in IN cord-257258-hu9oxea1 41 2 patients patient NNS cord-257258-hu9oxea1 41 3 with with IN cord-257258-hu9oxea1 41 4 hepatic hepatic JJ cord-257258-hu9oxea1 41 5 failure failure NN cord-257258-hu9oxea1 41 6 , , , cord-257258-hu9oxea1 41 7 which which WDT cord-257258-hu9oxea1 41 8 occurs occur VBZ cord-257258-hu9oxea1 41 9 with with IN cord-257258-hu9oxea1 41 10 multi multi JJ cord-257258-hu9oxea1 41 11 - - JJ cord-257258-hu9oxea1 41 12 organ organ JJ cord-257258-hu9oxea1 41 13 failure failure NN cord-257258-hu9oxea1 41 14 in in IN cord-257258-hu9oxea1 41 15 acute acute JJ cord-257258-hu9oxea1 41 16 respiratory respiratory JJ cord-257258-hu9oxea1 41 17 distress distress NN cord-257258-hu9oxea1 41 18 syndrome syndrome NN cord-257258-hu9oxea1 41 19 associated associate VBN cord-257258-hu9oxea1 41 20 with with IN cord-257258-hu9oxea1 41 21 COVID-19 COVID-19 NNP cord-257258-hu9oxea1 41 22 , , , cord-257258-hu9oxea1 41 23 the the DT cord-257258-hu9oxea1 41 24 clearance clearance NN cord-257258-hu9oxea1 41 25 of of IN cord-257258-hu9oxea1 41 26 hydroxychloroquine hydroxychloroquine NN cord-257258-hu9oxea1 41 27 is be VBZ cord-257258-hu9oxea1 41 28 delayed delay VBN cord-257258-hu9oxea1 41 29 , , , cord-257258-hu9oxea1 41 30 increasing increase VBG cord-257258-hu9oxea1 41 31 the the DT cord-257258-hu9oxea1 41 32 risk risk NN cord-257258-hu9oxea1 41 33 of of IN cord-257258-hu9oxea1 41 34 cardiac cardiac JJ cord-257258-hu9oxea1 41 35 arrhythmias arrhythmia NNS cord-257258-hu9oxea1 41 36 . . . cord-257258-hu9oxea1 42 1 Its -PRON- PRP$ cord-257258-hu9oxea1 42 2 general general JJ cord-257258-hu9oxea1 42 3 use use NN cord-257258-hu9oxea1 42 4 in in IN cord-257258-hu9oxea1 42 5 severely severely RB cord-257258-hu9oxea1 42 6 ill ill JJ cord-257258-hu9oxea1 42 7 COVID-19 covid-19 CD cord-257258-hu9oxea1 42 8 patients patient NNS cord-257258-hu9oxea1 42 9 , , , cord-257258-hu9oxea1 42 10 outside outside RB cord-257258-hu9oxea1 42 11 of of IN cord-257258-hu9oxea1 42 12 a a DT cord-257258-hu9oxea1 42 13 research research NN cord-257258-hu9oxea1 42 14 setting setting NN cord-257258-hu9oxea1 42 15 , , , cord-257258-hu9oxea1 42 16 carries carry VBZ cord-257258-hu9oxea1 42 17 the the DT cord-257258-hu9oxea1 42 18 risk risk NN cord-257258-hu9oxea1 42 19 of of IN cord-257258-hu9oxea1 42 20 unexpected unexpected JJ cord-257258-hu9oxea1 42 21 and and CC cord-257258-hu9oxea1 42 22 potentially potentially RB cord-257258-hu9oxea1 42 23 lethal lethal JJ cord-257258-hu9oxea1 42 24 side side NN cord-257258-hu9oxea1 42 25 effects effect NNS cord-257258-hu9oxea1 42 26 , , , cord-257258-hu9oxea1 42 27 while while IN cord-257258-hu9oxea1 42 28 learning learn VBG cord-257258-hu9oxea1 42 29 very very RB cord-257258-hu9oxea1 42 30 little little RB cord-257258-hu9oxea1 42 31 in in IN cord-257258-hu9oxea1 42 32 the the DT cord-257258-hu9oxea1 42 33 process process NN cord-257258-hu9oxea1 42 34 . . . cord-257258-hu9oxea1 43 1 Among among IN cord-257258-hu9oxea1 43 2 the the DT cord-257258-hu9oxea1 43 3 many many JJ cord-257258-hu9oxea1 43 4 ongoing ongoing JJ cord-257258-hu9oxea1 43 5 anti anti JJ cord-257258-hu9oxea1 43 6 - - JJ cord-257258-hu9oxea1 43 7 SARS SARS NNP cord-257258-hu9oxea1 43 8 - - HYPH cord-257258-hu9oxea1 43 9 CoV-2 CoV-2 NNP cord-257258-hu9oxea1 43 10 trials trial NNS cord-257258-hu9oxea1 43 11 , , , cord-257258-hu9oxea1 43 12 two two CD cord-257258-hu9oxea1 43 13 anti anti JJ cord-257258-hu9oxea1 43 14 - - NNS cord-257258-hu9oxea1 43 15 virals viral NNS cord-257258-hu9oxea1 43 16 developed develop VBN cord-257258-hu9oxea1 43 17 initially initially RB cord-257258-hu9oxea1 43 18 against against IN cord-257258-hu9oxea1 43 19 earlier early JJR cord-257258-hu9oxea1 43 20 outbreaks outbreak NNS cord-257258-hu9oxea1 43 21 have have VBP cord-257258-hu9oxea1 43 22 resurfaced resurface VBN cord-257258-hu9oxea1 43 23 [ [ -LRB- cord-257258-hu9oxea1 43 24 6 6 CD cord-257258-hu9oxea1 43 25 ] ] -RRB- cord-257258-hu9oxea1 43 26 . . . cord-257258-hu9oxea1 44 1 Remdesivir Remdesivir NNP cord-257258-hu9oxea1 44 2 ( ( -LRB- cord-257258-hu9oxea1 44 3 Gilead Gilead NNP cord-257258-hu9oxea1 44 4 ) ) -RRB- cord-257258-hu9oxea1 44 5 , , , cord-257258-hu9oxea1 44 6 a a DT cord-257258-hu9oxea1 44 7 reverse reverse JJ cord-257258-hu9oxea1 44 8 transcriptase transcriptase NN cord-257258-hu9oxea1 44 9 ( ( -LRB- cord-257258-hu9oxea1 44 10 RT RT NNP cord-257258-hu9oxea1 44 11 ) ) -RRB- cord-257258-hu9oxea1 44 12 inhibitor inhibitor NN cord-257258-hu9oxea1 44 13 designed design VBN cord-257258-hu9oxea1 44 14 originally originally RB cord-257258-hu9oxea1 44 15 against against IN cord-257258-hu9oxea1 44 16 SARS SARS NNP cord-257258-hu9oxea1 44 17 RT RT NNP cord-257258-hu9oxea1 44 18 , , , cord-257258-hu9oxea1 44 19 has have VBZ cord-257258-hu9oxea1 44 20 in in IN cord-257258-hu9oxea1 44 21 vitro vitro FW cord-257258-hu9oxea1 44 22 activity activity NN cord-257258-hu9oxea1 44 23 against against IN cord-257258-hu9oxea1 44 24 SARS SARS NNP cord-257258-hu9oxea1 44 25 - - HYPH cord-257258-hu9oxea1 44 26 CoV-2 CoV-2 NNP cord-257258-hu9oxea1 44 27 and and CC cord-257258-hu9oxea1 44 28 is be VBZ cord-257258-hu9oxea1 44 29 currently currently RB cord-257258-hu9oxea1 44 30 undergoing undergo VBG cord-257258-hu9oxea1 44 31 trials trial NNS cord-257258-hu9oxea1 44 32 in in IN cord-257258-hu9oxea1 44 33 multiple multiple JJ cord-257258-hu9oxea1 44 34 U.S. U.S. NNP cord-257258-hu9oxea1 44 35 centers center NNS cord-257258-hu9oxea1 44 36 and and CC cord-257258-hu9oxea1 44 37 abroad abroad RB cord-257258-hu9oxea1 44 38 . . . cord-257258-hu9oxea1 45 1 In in IN cord-257258-hu9oxea1 45 2 a a DT cord-257258-hu9oxea1 45 3 preliminary preliminary JJ cord-257258-hu9oxea1 45 4 report report NN cord-257258-hu9oxea1 45 5 of of IN cord-257258-hu9oxea1 45 6 53 53 CD cord-257258-hu9oxea1 45 7 patients patient NNS cord-257258-hu9oxea1 45 8 in in IN cord-257258-hu9oxea1 45 9 a a DT cord-257258-hu9oxea1 45 10 multi multi JJ cord-257258-hu9oxea1 45 11 - - JJ cord-257258-hu9oxea1 45 12 institutional institutional JJ cord-257258-hu9oxea1 45 13 compassionate compassionate JJ cord-257258-hu9oxea1 45 14 use use NN cord-257258-hu9oxea1 45 15 cohort cohort NN cord-257258-hu9oxea1 45 16 , , , cord-257258-hu9oxea1 45 17 including include VBG cord-257258-hu9oxea1 45 18 a a DT cord-257258-hu9oxea1 45 19 spectrum spectrum NN cord-257258-hu9oxea1 45 20 of of IN cord-257258-hu9oxea1 45 21 illness illness NN cord-257258-hu9oxea1 45 22 severity severity NN cord-257258-hu9oxea1 45 23 , , , cord-257258-hu9oxea1 45 24 68 68 CD cord-257258-hu9oxea1 45 25 % % NN cord-257258-hu9oxea1 45 26 had have VBD cord-257258-hu9oxea1 45 27 improvement improvement NN cord-257258-hu9oxea1 45 28 in in IN cord-257258-hu9oxea1 45 29 oxygenation oxygenation NN cord-257258-hu9oxea1 45 30 ; ; : cord-257258-hu9oxea1 45 31 however however RB cord-257258-hu9oxea1 45 32 , , , cord-257258-hu9oxea1 45 33 the the DT cord-257258-hu9oxea1 45 34 study study NN cord-257258-hu9oxea1 45 35 lacked lack VBD cord-257258-hu9oxea1 45 36 a a DT cord-257258-hu9oxea1 45 37 control control NN cord-257258-hu9oxea1 45 38 group group NN cord-257258-hu9oxea1 45 39 , , , cord-257258-hu9oxea1 45 40 so so CC cord-257258-hu9oxea1 45 41 the the DT cord-257258-hu9oxea1 45 42 benefit benefit NN cord-257258-hu9oxea1 45 43 is be VBZ cord-257258-hu9oxea1 45 44 difficult difficult JJ cord-257258-hu9oxea1 45 45 to to TO cord-257258-hu9oxea1 45 46 assess assess VB cord-257258-hu9oxea1 45 47 [ [ -LRB- cord-257258-hu9oxea1 45 48 7 7 CD cord-257258-hu9oxea1 45 49 ] ] -RRB- cord-257258-hu9oxea1 45 50 . . . cord-257258-hu9oxea1 46 1 Favipiravir Favipiravir NNP cord-257258-hu9oxea1 46 2 ( ( -LRB- cord-257258-hu9oxea1 46 3 Fujifilm Fujifilm NNP cord-257258-hu9oxea1 46 4 ) ) -RRB- cord-257258-hu9oxea1 46 5 , , , cord-257258-hu9oxea1 46 6 another another DT cord-257258-hu9oxea1 46 7 viral viral JJ cord-257258-hu9oxea1 46 8 replication replication NN cord-257258-hu9oxea1 46 9 inhibitor inhibitor NN cord-257258-hu9oxea1 46 10 designed design VBN cord-257258-hu9oxea1 46 11 for for IN cord-257258-hu9oxea1 46 12 treatment treatment NN cord-257258-hu9oxea1 46 13 of of IN cord-257258-hu9oxea1 46 14 influenza influenza NN cord-257258-hu9oxea1 46 15 , , , cord-257258-hu9oxea1 46 16 is be VBZ cord-257258-hu9oxea1 46 17 also also RB cord-257258-hu9oxea1 46 18 undergoing undergo VBG cord-257258-hu9oxea1 46 19 randomized randomized JJ cord-257258-hu9oxea1 46 20 trials trial NNS cord-257258-hu9oxea1 46 21 in in IN cord-257258-hu9oxea1 46 22 the the DT cord-257258-hu9oxea1 46 23 U.S. U.S. NNP cord-257258-hu9oxea1 46 24 and and CC cord-257258-hu9oxea1 46 25 abroad abroad RB cord-257258-hu9oxea1 46 26 . . . cord-257258-hu9oxea1 47 1 Selinexor Selinexor NNP cord-257258-hu9oxea1 47 2 , , , cord-257258-hu9oxea1 47 3 a a DT cord-257258-hu9oxea1 47 4 candidate candidate NN cord-257258-hu9oxea1 47 5 anti anti JJ cord-257258-hu9oxea1 47 6 - - JJ cord-257258-hu9oxea1 47 7 cancer cancer JJ cord-257258-hu9oxea1 47 8 drug drug NN cord-257258-hu9oxea1 47 9 that that WDT cord-257258-hu9oxea1 47 10 inhibits inhibit VBZ cord-257258-hu9oxea1 47 11 nuclear nuclear JJ cord-257258-hu9oxea1 47 12 export export NN cord-257258-hu9oxea1 47 13 of of IN cord-257258-hu9oxea1 47 14 viral viral JJ cord-257258-hu9oxea1 47 15 proteins protein NNS cord-257258-hu9oxea1 47 16 , , , cord-257258-hu9oxea1 47 17 is be VBZ cord-257258-hu9oxea1 47 18 also also RB cord-257258-hu9oxea1 47 19 the the DT cord-257258-hu9oxea1 47 20 subject subject NN cord-257258-hu9oxea1 47 21 of of IN cord-257258-hu9oxea1 47 22 expanded expand VBN cord-257258-hu9oxea1 47 23 studies study NNS cord-257258-hu9oxea1 47 24 against against IN cord-257258-hu9oxea1 47 25 COVID-19 COVID-19 NNP cord-257258-hu9oxea1 47 26 . . . cord-257258-hu9oxea1 48 1 Efforts effort NNS cord-257258-hu9oxea1 48 2 to to TO cord-257258-hu9oxea1 48 3 discover discover VB cord-257258-hu9oxea1 48 4 drugs drug NNS cord-257258-hu9oxea1 48 5 for for IN cord-257258-hu9oxea1 48 6 SARS SARS NNP cord-257258-hu9oxea1 48 7 - - HYPH cord-257258-hu9oxea1 48 8 CoV-2 CoV-2 NNP cord-257258-hu9oxea1 48 9 infection infection NN cord-257258-hu9oxea1 48 10 will will MD cord-257258-hu9oxea1 48 11 likely likely RB cord-257258-hu9oxea1 48 12 identify identify VB cord-257258-hu9oxea1 48 13 more more RBR cord-257258-hu9oxea1 48 14 effective effective JJ cord-257258-hu9oxea1 48 15 and and CC cord-257258-hu9oxea1 48 16 specifically specifically RB cord-257258-hu9oxea1 48 17 - - HYPH cord-257258-hu9oxea1 48 18 targeted target VBN cord-257258-hu9oxea1 48 19 compounds compound NNS cord-257258-hu9oxea1 48 20 [ [ -LRB- cord-257258-hu9oxea1 48 21 6 6 CD cord-257258-hu9oxea1 48 22 ] ] -RRB- cord-257258-hu9oxea1 48 23 . . . cord-257258-hu9oxea1 49 1 In in IN cord-257258-hu9oxea1 49 2 recent recent JJ cord-257258-hu9oxea1 49 3 years year NNS cord-257258-hu9oxea1 49 4 the the DT cord-257258-hu9oxea1 49 5 pharmaceutical pharmaceutical NN cord-257258-hu9oxea1 49 6 industry industry NN cord-257258-hu9oxea1 49 7 has have VBZ cord-257258-hu9oxea1 49 8 had have VBN cord-257258-hu9oxea1 49 9 remarkable remarkable JJ cord-257258-hu9oxea1 49 10 success success NN cord-257258-hu9oxea1 49 11 developing develop VBG cord-257258-hu9oxea1 49 12 antivirals antiviral NNS cord-257258-hu9oxea1 49 13 against against IN cord-257258-hu9oxea1 49 14 HIV HIV NNP cord-257258-hu9oxea1 49 15 - - HYPH cord-257258-hu9oxea1 49 16 AIDS AIDS NNP cord-257258-hu9oxea1 49 17 , , , cord-257258-hu9oxea1 49 18 hepatitis hepatitis NN cord-257258-hu9oxea1 49 19 B B NNP cord-257258-hu9oxea1 49 20 and and CC cord-257258-hu9oxea1 49 21 C C NNP cord-257258-hu9oxea1 49 22 , , , cord-257258-hu9oxea1 49 23 and and CC cord-257258-hu9oxea1 49 24 herpes herpes NN cord-257258-hu9oxea1 49 25 viruses virus NNS cord-257258-hu9oxea1 49 26 . . . cord-257258-hu9oxea1 50 1 There there EX cord-257258-hu9oxea1 50 2 are be VBP cord-257258-hu9oxea1 50 3 obvious obvious JJ cord-257258-hu9oxea1 50 4 SARS SARS NNP cord-257258-hu9oxea1 50 5 - - HYPH cord-257258-hu9oxea1 50 6 CoV-2 CoV-2 NNP cord-257258-hu9oxea1 50 7 targets target NNS cord-257258-hu9oxea1 50 8 : : : cord-257258-hu9oxea1 50 9 the the DT cord-257258-hu9oxea1 50 10 viral viral JJ cord-257258-hu9oxea1 50 11 reverse reverse NN cord-257258-hu9oxea1 50 12 transcriptase transcriptase NN cord-257258-hu9oxea1 50 13 necessary necessary JJ cord-257258-hu9oxea1 50 14 for for IN cord-257258-hu9oxea1 50 15 replication replication NN cord-257258-hu9oxea1 50 16 , , , cord-257258-hu9oxea1 50 17 a a DT cord-257258-hu9oxea1 50 18 protease protease NN cord-257258-hu9oxea1 50 19 TMPRSS2 TMPRSS2 NNP cord-257258-hu9oxea1 50 20 required require VBN cord-257258-hu9oxea1 50 21 to to TO cord-257258-hu9oxea1 50 22 cleave cleave VB cord-257258-hu9oxea1 50 23 the the DT cord-257258-hu9oxea1 50 24 spike spike NN cord-257258-hu9oxea1 50 25 protein protein NN cord-257258-hu9oxea1 50 26 that that WDT cord-257258-hu9oxea1 50 27 provides provide VBZ cord-257258-hu9oxea1 50 28 viral viral JJ cord-257258-hu9oxea1 50 29 entry entry NN cord-257258-hu9oxea1 50 30 [ [ -LRB- cord-257258-hu9oxea1 50 31 8 8 CD cord-257258-hu9oxea1 50 32 ] ] -RRB- cord-257258-hu9oxea1 50 33 , , , cord-257258-hu9oxea1 50 34 the the DT cord-257258-hu9oxea1 50 35 ACE2 ACE2 NNP cord-257258-hu9oxea1 50 36 receptor receptor NN cord-257258-hu9oxea1 50 37 on on IN cord-257258-hu9oxea1 50 38 lung lung NN cord-257258-hu9oxea1 50 39 epithelium epithelium NN cord-257258-hu9oxea1 50 40 that that WDT cord-257258-hu9oxea1 50 41 interacts interact VBZ cord-257258-hu9oxea1 50 42 with with IN cord-257258-hu9oxea1 50 43 spike spike NN cord-257258-hu9oxea1 50 44 , , , cord-257258-hu9oxea1 50 45 and and CC cord-257258-hu9oxea1 50 46 small small JJ cord-257258-hu9oxea1 50 47 molecules molecule NNS cord-257258-hu9oxea1 50 48 that that WDT cord-257258-hu9oxea1 50 49 inhibit inhibit VBP cord-257258-hu9oxea1 50 50 ACE2 ACE2 NNP cord-257258-hu9oxea1 50 51 . . . cord-257258-hu9oxea1 51 1 It -PRON- PRP cord-257258-hu9oxea1 51 2 is be VBZ cord-257258-hu9oxea1 51 3 possible possible JJ cord-257258-hu9oxea1 51 4 , , , cord-257258-hu9oxea1 51 5 although although IN cord-257258-hu9oxea1 51 6 unproven unproven JJ cord-257258-hu9oxea1 51 7 , , , cord-257258-hu9oxea1 51 8 that that IN cord-257258-hu9oxea1 51 9 common common JJ cord-257258-hu9oxea1 51 10 ACE2 ACE2 NNP cord-257258-hu9oxea1 51 11 receptor receptor NN cord-257258-hu9oxea1 51 12 inhibitors inhibitor NNS cord-257258-hu9oxea1 51 13 now now RB cord-257258-hu9oxea1 51 14 used use VBN cord-257258-hu9oxea1 51 15 as as IN cord-257258-hu9oxea1 51 16 anti anti JJ cord-257258-hu9oxea1 51 17 - - JJ cord-257258-hu9oxea1 51 18 hypertensives hypertensives NNP cord-257258-hu9oxea1 51 19 would would MD cord-257258-hu9oxea1 51 20 block block VB cord-257258-hu9oxea1 51 21 viral viral JJ cord-257258-hu9oxea1 51 22 entry entry NN cord-257258-hu9oxea1 51 23 and and CC cord-257258-hu9oxea1 51 24 mitigate mitigate VB cord-257258-hu9oxea1 51 25 infection infection NN cord-257258-hu9oxea1 51 26 . . . cord-257258-hu9oxea1 52 1 Single single JJ cord-257258-hu9oxea1 52 2 agent agent NN cord-257258-hu9oxea1 52 3 antiviral antiviral JJ cord-257258-hu9oxea1 52 4 therapy therapy NN cord-257258-hu9oxea1 52 5 may may MD cord-257258-hu9oxea1 52 6 not not RB cord-257258-hu9oxea1 52 7 be be VB cord-257258-hu9oxea1 52 8 sufficient sufficient JJ cord-257258-hu9oxea1 52 9 . . . cord-257258-hu9oxea1 53 1 Antivirals antiviral NNS cord-257258-hu9oxea1 53 2 in in IN cord-257258-hu9oxea1 53 3 combination combination NN cord-257258-hu9oxea1 53 4 ( ( -LRB- cord-257258-hu9oxea1 53 5 as as IN cord-257258-hu9oxea1 53 6 they -PRON- PRP cord-257258-hu9oxea1 53 7 are be VBP cord-257258-hu9oxea1 53 8 now now RB cord-257258-hu9oxea1 53 9 used use VBN cord-257258-hu9oxea1 53 10 against against IN cord-257258-hu9oxea1 53 11 HIV HIV NNP cord-257258-hu9oxea1 53 12 and and CC cord-257258-hu9oxea1 53 13 hepatitis hepatitis NN cord-257258-hu9oxea1 53 14 infection infection NN cord-257258-hu9oxea1 53 15 ) ) -RRB- cord-257258-hu9oxea1 53 16 could could MD cord-257258-hu9oxea1 53 17 be be VB cord-257258-hu9oxea1 53 18 invaluable invaluable JJ cord-257258-hu9oxea1 53 19 in in IN cord-257258-hu9oxea1 53 20 prophylaxis prophylaxis NN cord-257258-hu9oxea1 53 21 against against IN cord-257258-hu9oxea1 53 22 infection infection NN cord-257258-hu9oxea1 53 23 and and CC cord-257258-hu9oxea1 53 24 in in IN cord-257258-hu9oxea1 53 25 treating treat VBG cord-257258-hu9oxea1 53 26 infection infection NN cord-257258-hu9oxea1 53 27 before before IN cord-257258-hu9oxea1 53 28 it -PRON- PRP cord-257258-hu9oxea1 53 29 becomes become VBZ cord-257258-hu9oxea1 53 30 life life NN cord-257258-hu9oxea1 53 31 - - HYPH cord-257258-hu9oxea1 53 32 threatening threaten VBG cord-257258-hu9oxea1 53 33 . . . cord-257258-hu9oxea1 54 1 A a DT cord-257258-hu9oxea1 54 2 recent recent JJ cord-257258-hu9oxea1 54 3 article article NN cord-257258-hu9oxea1 54 4 in in IN cord-257258-hu9oxea1 54 5 Science Science NNP cord-257258-hu9oxea1 54 6 [ [ -LRB- cord-257258-hu9oxea1 54 7 9 9 CD cord-257258-hu9oxea1 54 8 ] ] -RRB- cord-257258-hu9oxea1 54 9 describes describe VBZ cord-257258-hu9oxea1 54 10 the the DT cord-257258-hu9oxea1 54 11 relatively relatively RB cord-257258-hu9oxea1 54 12 potent potent JJ cord-257258-hu9oxea1 54 13 antiviral antiviral JJ cord-257258-hu9oxea1 54 14 activity activity NN cord-257258-hu9oxea1 54 15 of of IN cord-257258-hu9oxea1 54 16 berta berta NNP cord-257258-hu9oxea1 54 17 - - HYPH cord-257258-hu9oxea1 54 18 D D NNP cord-257258-hu9oxea1 54 19 - - HYPH cord-257258-hu9oxea1 54 20 N4 N4 NNP cord-257258-hu9oxea1 54 21 hydroxycytidine hydroxycytidine NN cord-257258-hu9oxea1 54 22 against against IN cord-257258-hu9oxea1 54 23 SARS SARS NNP cord-257258-hu9oxea1 54 24 - - HYPH cord-257258-hu9oxea1 54 25 CoV-2 CoV-2 NNP cord-257258-hu9oxea1 54 26 in in IN cord-257258-hu9oxea1 54 27 human human JJ cord-257258-hu9oxea1 54 28 epithelial epithelial JJ cord-257258-hu9oxea1 54 29 airway airway NN cord-257258-hu9oxea1 54 30 cultures culture NNS cord-257258-hu9oxea1 54 31 . . . cord-257258-hu9oxea1 55 1 In in IN cord-257258-hu9oxea1 55 2 vivo vivo NNP cord-257258-hu9oxea1 55 3 studies study NNS cord-257258-hu9oxea1 55 4 against against IN cord-257258-hu9oxea1 55 5 the the DT cord-257258-hu9oxea1 55 6 MERS MERS NNP cord-257258-hu9oxea1 55 7 and and CC cord-257258-hu9oxea1 55 8 SARS SARS NNP cord-257258-hu9oxea1 55 9 viruses virus NNS cord-257258-hu9oxea1 55 10 ( ( -LRB- cord-257258-hu9oxea1 55 11 but but CC cord-257258-hu9oxea1 55 12 not not RB cord-257258-hu9oxea1 55 13 against against IN cord-257258-hu9oxea1 55 14 SARS SARS NNP cord-257258-hu9oxea1 55 15 - - HYPH cord-257258-hu9oxea1 55 16 CoV-2 CoV-2 NNP cord-257258-hu9oxea1 55 17 ) ) -RRB- cord-257258-hu9oxea1 55 18 showed show VBD cord-257258-hu9oxea1 55 19 partial partial JJ cord-257258-hu9oxea1 55 20 protection protection NN cord-257258-hu9oxea1 55 21 against against IN cord-257258-hu9oxea1 55 22 lung lung NN cord-257258-hu9oxea1 55 23 injury injury NN cord-257258-hu9oxea1 55 24 , , , cord-257258-hu9oxea1 55 25 but but CC cord-257258-hu9oxea1 55 26 the the DT cord-257258-hu9oxea1 55 27 effect effect NN cord-257258-hu9oxea1 55 28 was be VBD cord-257258-hu9oxea1 55 29 dependent dependent JJ cord-257258-hu9oxea1 55 30 on on IN cord-257258-hu9oxea1 55 31 early early JJ cord-257258-hu9oxea1 55 32 drug drug NN cord-257258-hu9oxea1 55 33 administration administration NN cord-257258-hu9oxea1 55 34 after after IN cord-257258-hu9oxea1 55 35 inoculation inoculation NN cord-257258-hu9oxea1 55 36 of of IN cord-257258-hu9oxea1 55 37 the the DT cord-257258-hu9oxea1 55 38 virus virus NN cord-257258-hu9oxea1 55 39 . . . cord-257258-hu9oxea1 56 1 The the DT cord-257258-hu9oxea1 56 2 study study NN cord-257258-hu9oxea1 56 3 lacks lack VBZ cord-257258-hu9oxea1 56 4 pharmacokinetic pharmacokinetic JJ cord-257258-hu9oxea1 56 5 data datum NNS cord-257258-hu9oxea1 56 6 to to TO cord-257258-hu9oxea1 56 7 assure assure VB cord-257258-hu9oxea1 56 8 that that IN cord-257258-hu9oxea1 56 9 the the DT cord-257258-hu9oxea1 56 10 drug drug NN cord-257258-hu9oxea1 56 11 reaches reach VBZ cord-257258-hu9oxea1 56 12 and and CC cord-257258-hu9oxea1 56 13 maintains maintain VBZ cord-257258-hu9oxea1 56 14 significant significant JJ cord-257258-hu9oxea1 56 15 antiviral antiviral JJ cord-257258-hu9oxea1 56 16 concentrations concentration NNS cord-257258-hu9oxea1 56 17 in in IN cord-257258-hu9oxea1 56 18 mice mouse NNS cord-257258-hu9oxea1 56 19 . . . cord-257258-hu9oxea1 57 1 Notably notably RB cord-257258-hu9oxea1 57 2 , , , cord-257258-hu9oxea1 57 3 the the DT cord-257258-hu9oxea1 57 4 research research NN cord-257258-hu9oxea1 57 5 lacks lack VBZ cord-257258-hu9oxea1 57 6 a a DT cord-257258-hu9oxea1 57 7 suitable suitable JJ cord-257258-hu9oxea1 57 8 animal animal NN cord-257258-hu9oxea1 57 9 model model NN cord-257258-hu9oxea1 57 10 for for IN cord-257258-hu9oxea1 57 11 SARS SARS NNP cord-257258-hu9oxea1 57 12 - - HYPH cord-257258-hu9oxea1 57 13 CoV-2 CoV-2 NNP cord-257258-hu9oxea1 57 14 antiviral antiviral JJ cord-257258-hu9oxea1 57 15 testing testing NN cord-257258-hu9oxea1 57 16 , , , cord-257258-hu9oxea1 57 17 but but CC cord-257258-hu9oxea1 57 18 testing test VBG cord-257258-hu9oxea1 57 19 against against IN cord-257258-hu9oxea1 57 20 monkey monkey NN cord-257258-hu9oxea1 57 21 models model NNS cord-257258-hu9oxea1 57 22 may may MD cord-257258-hu9oxea1 57 23 be be VB cord-257258-hu9oxea1 57 24 possible possible JJ cord-257258-hu9oxea1 57 25 in in IN cord-257258-hu9oxea1 57 26 the the DT cord-257258-hu9oxea1 57 27 near near JJ cord-257258-hu9oxea1 57 28 future future NN cord-257258-hu9oxea1 58 1 An an DT cord-257258-hu9oxea1 58 2 additional additional JJ cord-257258-hu9oxea1 58 3 intriguing intriguing JJ cord-257258-hu9oxea1 58 4 therapeutic therapeutic JJ cord-257258-hu9oxea1 58 5 possibility possibility NN cord-257258-hu9oxea1 58 6 will will MD cord-257258-hu9oxea1 58 7 be be VB cord-257258-hu9oxea1 58 8 to to TO cord-257258-hu9oxea1 58 9 suppress suppress VB cord-257258-hu9oxea1 58 10 the the DT cord-257258-hu9oxea1 58 11 cytokine cytokine NN cord-257258-hu9oxea1 58 12 storm storm NN cord-257258-hu9oxea1 58 13 that that WDT cord-257258-hu9oxea1 58 14 results result VBZ cord-257258-hu9oxea1 58 15 from from IN cord-257258-hu9oxea1 58 16 the the DT cord-257258-hu9oxea1 58 17 host host NN cord-257258-hu9oxea1 58 18 inflammatory inflammatory JJ cord-257258-hu9oxea1 58 19 response response NN cord-257258-hu9oxea1 58 20 to to IN cord-257258-hu9oxea1 58 21 the the DT cord-257258-hu9oxea1 58 22 virus virus NN cord-257258-hu9oxea1 58 23 . . . cord-257258-hu9oxea1 59 1 The the DT cord-257258-hu9oxea1 59 2 release release NN cord-257258-hu9oxea1 59 3 of of IN cord-257258-hu9oxea1 59 4 cytokines cytokine NNS cord-257258-hu9oxea1 59 5 appears appear VBZ cord-257258-hu9oxea1 59 6 to to TO cord-257258-hu9oxea1 59 7 play play VB cord-257258-hu9oxea1 59 8 a a DT cord-257258-hu9oxea1 59 9 central central JJ cord-257258-hu9oxea1 59 10 role role NN cord-257258-hu9oxea1 59 11 in in IN cord-257258-hu9oxea1 59 12 pulmonary pulmonary JJ cord-257258-hu9oxea1 59 13 edema edema NN cord-257258-hu9oxea1 59 14 , , , cord-257258-hu9oxea1 59 15 inflammation inflammation NN cord-257258-hu9oxea1 59 16 , , , cord-257258-hu9oxea1 59 17 and and CC cord-257258-hu9oxea1 59 18 respiratory respiratory JJ cord-257258-hu9oxea1 59 19 failure failure NN cord-257258-hu9oxea1 59 20 associated associate VBN cord-257258-hu9oxea1 59 21 with with IN cord-257258-hu9oxea1 59 22 COVID-19 COVID-19 NNP cord-257258-hu9oxea1 59 23 [ [ -LRB- cord-257258-hu9oxea1 59 24 10 10 CD cord-257258-hu9oxea1 59 25 ] ] -RRB- cord-257258-hu9oxea1 59 26 . . . cord-257258-hu9oxea1 60 1 Although although IN cord-257258-hu9oxea1 60 2 evidence evidence NN cord-257258-hu9oxea1 60 3 is be VBZ cord-257258-hu9oxea1 60 4 preliminary preliminary JJ cord-257258-hu9oxea1 60 5 , , , cord-257258-hu9oxea1 60 6 IL-6 IL-6 NNP cord-257258-hu9oxea1 60 7 may may MD cord-257258-hu9oxea1 60 8 be be VB cord-257258-hu9oxea1 60 9 a a DT cord-257258-hu9oxea1 60 10 key key JJ cord-257258-hu9oxea1 60 11 component component NN cord-257258-hu9oxea1 60 12 of of IN cord-257258-hu9oxea1 60 13 the the DT cord-257258-hu9oxea1 60 14 cytokine cytokine NN cord-257258-hu9oxea1 60 15 storm storm NN cord-257258-hu9oxea1 60 16 : : : cord-257258-hu9oxea1 60 17 anecdotal anecdotal JJ cord-257258-hu9oxea1 60 18 observations observation NNS cord-257258-hu9oxea1 60 19 of of IN cord-257258-hu9oxea1 60 20 beneficial beneficial JJ cord-257258-hu9oxea1 60 21 responses response NNS cord-257258-hu9oxea1 60 22 in in IN cord-257258-hu9oxea1 60 23 patients patient NNS cord-257258-hu9oxea1 60 24 treated treat VBN cord-257258-hu9oxea1 60 25 with with IN cord-257258-hu9oxea1 60 26 anti anti JJ cord-257258-hu9oxea1 60 27 - - JJ cord-257258-hu9oxea1 60 28 IL-6 il-6 JJ cord-257258-hu9oxea1 60 29 receptor receptor NN cord-257258-hu9oxea1 60 30 antibodies antibody NNS cord-257258-hu9oxea1 60 31 support support VBP cord-257258-hu9oxea1 60 32 this this DT cord-257258-hu9oxea1 60 33 notion notion NN cord-257258-hu9oxea1 60 34 . . . cord-257258-hu9oxea1 61 1 Two two CD cord-257258-hu9oxea1 61 2 IL-6 IL-6 NNP cord-257258-hu9oxea1 61 3 antibodies antibody NNS cord-257258-hu9oxea1 61 4 ( ( -LRB- cord-257258-hu9oxea1 61 5 tocilizumab tocilizumab NNP cord-257258-hu9oxea1 61 6 from from IN cord-257258-hu9oxea1 61 7 Hoffman Hoffman NNP cord-257258-hu9oxea1 61 8 - - HYPH cord-257258-hu9oxea1 61 9 La La NNP cord-257258-hu9oxea1 61 10 Roche Roche NNP cord-257258-hu9oxea1 61 11 and and CC cord-257258-hu9oxea1 61 12 sarilumab sarilumab NN cord-257258-hu9oxea1 61 13 from from IN cord-257258-hu9oxea1 61 14 Sanofi Sanofi NNP cord-257258-hu9oxea1 61 15 ) ) -RRB- cord-257258-hu9oxea1 61 16 are be VBP cord-257258-hu9oxea1 61 17 currently currently RB cord-257258-hu9oxea1 61 18 approved approve VBN cord-257258-hu9oxea1 61 19 for for IN cord-257258-hu9oxea1 61 20 rheumatoid rheumatoid NN cord-257258-hu9oxea1 61 21 arthritis arthritis NN cord-257258-hu9oxea1 61 22 and and CC cord-257258-hu9oxea1 61 23 have have VBP cord-257258-hu9oxea1 61 24 anecdotal anecdotal JJ cord-257258-hu9oxea1 61 25 efficacy efficacy NN cord-257258-hu9oxea1 61 26 in in IN cord-257258-hu9oxea1 61 27 treating treat VBG cord-257258-hu9oxea1 61 28 side side NN cord-257258-hu9oxea1 61 29 effects effect NNS cord-257258-hu9oxea1 61 30 of of IN cord-257258-hu9oxea1 61 31 cancer cancer NN cord-257258-hu9oxea1 61 32 immunotherapy immunotherapy NN cord-257258-hu9oxea1 61 33 . . . cord-257258-hu9oxea1 62 1 Multiple multiple JJ cord-257258-hu9oxea1 62 2 trials trial NNS cord-257258-hu9oxea1 62 3 of of IN cord-257258-hu9oxea1 62 4 anti anti JJ cord-257258-hu9oxea1 62 5 - - JJ cord-257258-hu9oxea1 62 6 IL-6 il-6 JJ cord-257258-hu9oxea1 62 7 receptor receptor NN cord-257258-hu9oxea1 62 8 antibody antibody NN cord-257258-hu9oxea1 62 9 in in IN cord-257258-hu9oxea1 62 10 ventilator ventilator NN cord-257258-hu9oxea1 62 11 - - HYPH cord-257258-hu9oxea1 62 12 dependent dependent JJ cord-257258-hu9oxea1 62 13 COVID-19 covid-19 JJ cord-257258-hu9oxea1 62 14 infection infection NN cord-257258-hu9oxea1 62 15 are be VBP cord-257258-hu9oxea1 62 16 under under IN cord-257258-hu9oxea1 62 17 way way NN cord-257258-hu9oxea1 62 18 . . . cord-257258-hu9oxea1 63 1 An an DT cord-257258-hu9oxea1 63 2 inhibitor inhibitor NN cord-257258-hu9oxea1 63 3 of of IN cord-257258-hu9oxea1 63 4 the the DT cord-257258-hu9oxea1 63 5 JAK2-STAT jak2-stat NN cord-257258-hu9oxea1 63 6 pathway pathway NN cord-257258-hu9oxea1 63 7 ( ( -LRB- cord-257258-hu9oxea1 63 8 ruxolitinib ruxolitinib NNP cord-257258-hu9oxea1 63 9 , , , cord-257258-hu9oxea1 63 10 Novartis Novartis NNP cord-257258-hu9oxea1 63 11 ) ) -RRB- cord-257258-hu9oxea1 63 12 , , , cord-257258-hu9oxea1 63 13 currently currently RB cord-257258-hu9oxea1 63 14 used use VBN cord-257258-hu9oxea1 63 15 against against IN cord-257258-hu9oxea1 63 16 myelofibrosis myelofibrosis NNP cord-257258-hu9oxea1 63 17 , , , cord-257258-hu9oxea1 63 18 also also RB cord-257258-hu9oxea1 63 19 blocks block VBZ cord-257258-hu9oxea1 63 20 cytokine cytokine NN cord-257258-hu9oxea1 63 21 production production NN cord-257258-hu9oxea1 63 22 and and CC cord-257258-hu9oxea1 63 23 will will MD cord-257258-hu9oxea1 63 24 be be VB cord-257258-hu9oxea1 63 25 tested test VBN cord-257258-hu9oxea1 63 26 . . . cord-257258-hu9oxea1 64 1 A a DT cord-257258-hu9oxea1 64 2 more more RBR cord-257258-hu9oxea1 64 3 detailed detailed JJ cord-257258-hu9oxea1 64 4 understanding understanding NN cord-257258-hu9oxea1 64 5 of of IN cord-257258-hu9oxea1 64 6 the the DT cord-257258-hu9oxea1 64 7 role role NN cord-257258-hu9oxea1 64 8 of of IN cord-257258-hu9oxea1 64 9 cytokines cytokine NNS cord-257258-hu9oxea1 64 10 in in IN cord-257258-hu9oxea1 64 11 lung lung NN cord-257258-hu9oxea1 64 12 injury injury NN cord-257258-hu9oxea1 64 13 would would MD cord-257258-hu9oxea1 64 14 be be VB cord-257258-hu9oxea1 64 15 invaluable invaluable JJ cord-257258-hu9oxea1 64 16 , , , cord-257258-hu9oxea1 64 17 and and CC cord-257258-hu9oxea1 64 18 additional additional JJ cord-257258-hu9oxea1 64 19 immune immune JJ cord-257258-hu9oxea1 64 20 system system NN cord-257258-hu9oxea1 64 21 targets target NNS cord-257258-hu9oxea1 64 22 will will MD cord-257258-hu9oxea1 64 23 likely likely RB cord-257258-hu9oxea1 64 24 emerge emerge VB cord-257258-hu9oxea1 64 25 from from IN cord-257258-hu9oxea1 64 26 this this DT cord-257258-hu9oxea1 64 27 research research NN cord-257258-hu9oxea1 64 28 . . . cord-257258-hu9oxea1 65 1 Finally finally RB cord-257258-hu9oxea1 65 2 , , , cord-257258-hu9oxea1 65 3 there there EX cord-257258-hu9oxea1 65 4 is be VBZ cord-257258-hu9oxea1 65 5 promise promise NN cord-257258-hu9oxea1 65 6 in in IN cord-257258-hu9oxea1 65 7 the the DT cord-257258-hu9oxea1 65 8 use use NN cord-257258-hu9oxea1 65 9 of of IN cord-257258-hu9oxea1 65 10 hyperimmune hyperimmune NNP cord-257258-hu9oxea1 65 11 serum serum NN cord-257258-hu9oxea1 65 12 as as IN cord-257258-hu9oxea1 65 13 passive passive JJ cord-257258-hu9oxea1 65 14 treatment treatment NN cord-257258-hu9oxea1 65 15 of of IN cord-257258-hu9oxea1 65 16 desperately desperately RB cord-257258-hu9oxea1 65 17 ill ill JJ cord-257258-hu9oxea1 65 18 patients patient NNS cord-257258-hu9oxea1 65 19 . . . cord-257258-hu9oxea1 66 1 Very very RB cord-257258-hu9oxea1 66 2 limited limited JJ cord-257258-hu9oxea1 66 3 experience experience NN cord-257258-hu9oxea1 66 4 , , , cord-257258-hu9oxea1 66 5 anecdotal anecdotal JJ cord-257258-hu9oxea1 66 6 at at IN cord-257258-hu9oxea1 66 7 best good JJS cord-257258-hu9oxea1 66 8 , , , cord-257258-hu9oxea1 66 9 suggests suggest VBZ cord-257258-hu9oxea1 66 10 that that IN cord-257258-hu9oxea1 66 11 antibodies antibody NNS cord-257258-hu9oxea1 66 12 can can MD cord-257258-hu9oxea1 66 13 mitigate mitigate VB cord-257258-hu9oxea1 66 14 infection infection NN cord-257258-hu9oxea1 66 15 in in IN cord-257258-hu9oxea1 66 16 these these DT cord-257258-hu9oxea1 66 17 patients patient NNS cord-257258-hu9oxea1 66 18 [ [ -LRB- cord-257258-hu9oxea1 66 19 11 11 CD cord-257258-hu9oxea1 66 20 ] ] -RRB- cord-257258-hu9oxea1 66 21 . . . cord-257258-hu9oxea1 67 1 Companies company NNS cord-257258-hu9oxea1 67 2 are be VBP cord-257258-hu9oxea1 67 3 investigating investigate VBG cord-257258-hu9oxea1 67 4 the the DT cord-257258-hu9oxea1 67 5 development development NN cord-257258-hu9oxea1 67 6 of of IN cord-257258-hu9oxea1 67 7 antiviral antiviral JJ cord-257258-hu9oxea1 67 8 monoclonal monoclonal JJ cord-257258-hu9oxea1 67 9 antibodies antibody NNS cord-257258-hu9oxea1 67 10 for for IN cord-257258-hu9oxea1 67 11 this this DT cord-257258-hu9oxea1 67 12 purpose purpose NN cord-257258-hu9oxea1 67 13 , , , cord-257258-hu9oxea1 67 14 and and CC cord-257258-hu9oxea1 67 15 convalescent convalescent JJ cord-257258-hu9oxea1 67 16 sera sera NNP cord-257258-hu9oxea1 67 17 are be VBP cord-257258-hu9oxea1 67 18 also also RB cord-257258-hu9oxea1 67 19 being be VBG cord-257258-hu9oxea1 67 20 tested test VBN cord-257258-hu9oxea1 67 21 . . . cord-257258-hu9oxea1 68 1 In in IN cord-257258-hu9oxea1 68 2 conclusion conclusion NN cord-257258-hu9oxea1 68 3 , , , cord-257258-hu9oxea1 68 4 from from IN cord-257258-hu9oxea1 68 5 the the DT cord-257258-hu9oxea1 68 6 perspective perspective NN cord-257258-hu9oxea1 68 7 of of IN cord-257258-hu9oxea1 68 8 long long JJ cord-257258-hu9oxea1 68 9 - - HYPH cord-257258-hu9oxea1 68 10 term term NN cord-257258-hu9oxea1 68 11 control control NN cord-257258-hu9oxea1 68 12 of of IN cord-257258-hu9oxea1 68 13 coronavirus coronavirus NN cord-257258-hu9oxea1 68 14 infection infection NN cord-257258-hu9oxea1 68 15 , , , cord-257258-hu9oxea1 68 16 both both DT cord-257258-hu9oxea1 68 17 vaccines vaccine NNS cord-257258-hu9oxea1 68 18 and and CC cord-257258-hu9oxea1 68 19 antivirals antiviral NNS cord-257258-hu9oxea1 68 20 will will MD cord-257258-hu9oxea1 68 21 be be VB cord-257258-hu9oxea1 68 22 necessary necessary JJ cord-257258-hu9oxea1 68 23 to to TO cord-257258-hu9oxea1 68 24 avoid avoid VB cord-257258-hu9oxea1 68 25 the the DT cord-257258-hu9oxea1 68 26 death death NN cord-257258-hu9oxea1 68 27 and and CC cord-257258-hu9oxea1 68 28 destruction destruction NN cord-257258-hu9oxea1 68 29 imposed impose VBN cord-257258-hu9oxea1 68 30 by by IN cord-257258-hu9oxea1 68 31 the the DT cord-257258-hu9oxea1 68 32 current current JJ cord-257258-hu9oxea1 68 33 epidemic epidemic NN cord-257258-hu9oxea1 68 34 . . . cord-257258-hu9oxea1 69 1 Vastly vastly RB cord-257258-hu9oxea1 69 2 improved improve VBN cord-257258-hu9oxea1 69 3 preparedness preparedness NN cord-257258-hu9oxea1 69 4 , , , cord-257258-hu9oxea1 69 5 early early JJ cord-257258-hu9oxea1 69 6 deployment deployment NN cord-257258-hu9oxea1 69 7 of of IN cord-257258-hu9oxea1 69 8 viral viral JJ cord-257258-hu9oxea1 69 9 testing testing NN cord-257258-hu9oxea1 69 10 , , , cord-257258-hu9oxea1 69 11 and and CC cord-257258-hu9oxea1 69 12 quarantine quarantine NN cord-257258-hu9oxea1 69 13 of of IN cord-257258-hu9oxea1 69 14 infected infected JJ cord-257258-hu9oxea1 69 15 individuals individual NNS cord-257258-hu9oxea1 69 16 will will MD cord-257258-hu9oxea1 69 17 help help VB cord-257258-hu9oxea1 69 18 limit limit VB cord-257258-hu9oxea1 69 19 the the DT cord-257258-hu9oxea1 69 20 spread spread NN cord-257258-hu9oxea1 69 21 of of IN cord-257258-hu9oxea1 69 22 the the DT cord-257258-hu9oxea1 69 23 next next JJ cord-257258-hu9oxea1 69 24 wave wave NN cord-257258-hu9oxea1 69 25 of of IN cord-257258-hu9oxea1 69 26 coronavirus coronavirus NN cord-257258-hu9oxea1 69 27 infection infection NN cord-257258-hu9oxea1 69 28 . . . cord-257258-hu9oxea1 70 1 However however RB cord-257258-hu9oxea1 70 2 , , , cord-257258-hu9oxea1 70 3 vaccine vaccine NN cord-257258-hu9oxea1 70 4 development development NN cord-257258-hu9oxea1 70 5 and and CC cord-257258-hu9oxea1 70 6 its -PRON- PRP$ cord-257258-hu9oxea1 70 7 worldwide worldwide JJ cord-257258-hu9oxea1 70 8 implementation implementation NN cord-257258-hu9oxea1 70 9 , , , cord-257258-hu9oxea1 70 10 coupled couple VBN cord-257258-hu9oxea1 70 11 with with IN cord-257258-hu9oxea1 70 12 effective effective JJ cord-257258-hu9oxea1 70 13 antiviral antiviral JJ cord-257258-hu9oxea1 70 14 treatment treatment NN cord-257258-hu9oxea1 70 15 , , , cord-257258-hu9oxea1 70 16 will will MD cord-257258-hu9oxea1 70 17 be be VB cord-257258-hu9oxea1 70 18 required require VBN cord-257258-hu9oxea1 70 19 to to TO cord-257258-hu9oxea1 70 20 control control VB cord-257258-hu9oxea1 70 21 COVID-19 covid-19 VB cord-257258-hu9oxea1 70 22 and and CC cord-257258-hu9oxea1 70 23 prevent prevent VB cord-257258-hu9oxea1 70 24 another another DT cord-257258-hu9oxea1 70 25 pandemic pandemic NN cord-257258-hu9oxea1 70 26 . . . cord-257258-hu9oxea1 71 1 In in IN cord-257258-hu9oxea1 71 2 order order NN cord-257258-hu9oxea1 71 3 to to TO cord-257258-hu9oxea1 71 4 be be VB cord-257258-hu9oxea1 71 5 ready ready JJ cord-257258-hu9oxea1 71 6 for for IN cord-257258-hu9oxea1 71 7 the the DT cord-257258-hu9oxea1 71 8 next next JJ cord-257258-hu9oxea1 71 9 iteration iteration NN cord-257258-hu9oxea1 71 10 of of IN cord-257258-hu9oxea1 71 11 COVID-19 COVID-19 NNP cord-257258-hu9oxea1 71 12 , , , cord-257258-hu9oxea1 71 13 the the DT cord-257258-hu9oxea1 71 14 worldwide worldwide JJ cord-257258-hu9oxea1 71 15 medical medical JJ cord-257258-hu9oxea1 71 16 community community NN cord-257258-hu9oxea1 71 17 will will MD cord-257258-hu9oxea1 71 18 need need VB cord-257258-hu9oxea1 71 19 to to TO cord-257258-hu9oxea1 71 20 cooperate cooperate VB cord-257258-hu9oxea1 71 21 in in IN cord-257258-hu9oxea1 71 22 conducting conduct VBG cord-257258-hu9oxea1 71 23 extensive extensive JJ cord-257258-hu9oxea1 71 24 clinical clinical JJ cord-257258-hu9oxea1 71 25 trials trial NNS cord-257258-hu9oxea1 71 26 of of IN cord-257258-hu9oxea1 71 27 vaccines vaccine NNS cord-257258-hu9oxea1 71 28 , , , cord-257258-hu9oxea1 71 29 antivirals antiviral NNS cord-257258-hu9oxea1 71 30 , , , cord-257258-hu9oxea1 71 31 and and CC cord-257258-hu9oxea1 71 32 immune immune JJ cord-257258-hu9oxea1 71 33 therapies therapy NNS cord-257258-hu9oxea1 71 34 on on IN cord-257258-hu9oxea1 71 35 an an DT cord-257258-hu9oxea1 71 36 accelerated accelerated JJ cord-257258-hu9oxea1 71 37 time time NN cord-257258-hu9oxea1 71 38 scale scale NN cord-257258-hu9oxea1 71 39 . . . cord-257258-hu9oxea1 72 1 Sadly sadly RB cord-257258-hu9oxea1 72 2 , , , cord-257258-hu9oxea1 72 3 but but CC cord-257258-hu9oxea1 72 4 necessarily necessarily RB cord-257258-hu9oxea1 72 5 , , , cord-257258-hu9oxea1 72 6 this this DT cord-257258-hu9oxea1 72 7 worldwide worldwide JJ cord-257258-hu9oxea1 72 8 effort effort NN cord-257258-hu9oxea1 72 9 will will MD cord-257258-hu9oxea1 72 10 divert divert VB cord-257258-hu9oxea1 72 11 resources resource NNS cord-257258-hu9oxea1 72 12 from from IN cord-257258-hu9oxea1 72 13 other other JJ cord-257258-hu9oxea1 72 14 areas area NNS cord-257258-hu9oxea1 72 15 of of IN cord-257258-hu9oxea1 72 16 medical medical JJ cord-257258-hu9oxea1 72 17 research research NN cord-257258-hu9oxea1 72 18 , , , cord-257258-hu9oxea1 72 19 including include VBG cord-257258-hu9oxea1 72 20 cancer cancer NN cord-257258-hu9oxea1 72 21 research research NN cord-257258-hu9oxea1 72 22 , , , cord-257258-hu9oxea1 72 23 for for IN cord-257258-hu9oxea1 72 24 the the DT cord-257258-hu9oxea1 72 25 foreseeable foreseeable JJ cord-257258-hu9oxea1 72 26 future future NN cord-257258-hu9oxea1 72 27 , , , cord-257258-hu9oxea1 72 28 but but CC cord-257258-hu9oxea1 72 29 we -PRON- PRP cord-257258-hu9oxea1 72 30 have have VBP cord-257258-hu9oxea1 72 31 no no DT cord-257258-hu9oxea1 72 32 choice choice NN cord-257258-hu9oxea1 72 33 . . . cord-257258-hu9oxea1 73 1 COVID-19 covid-19 JJ cord-257258-hu9oxea1 73 2 vaccine vaccine NN cord-257258-hu9oxea1 73 3 frontrunners frontrunner NNS cord-257258-hu9oxea1 73 4 . . . cord-257258-hu9oxea1 74 1 The the DT cord-257258-hu9oxea1 74 2 Scientist Scientist NNP cord-257258-hu9oxea1 74 3 Developing develop VBG cord-257258-hu9oxea1 74 4 COVID-19 COVID-19 , cord-257258-hu9oxea1 74 5 vaccines vaccine NNS cord-257258-hu9oxea1 74 6 at at IN cord-257258-hu9oxea1 74 7 pandemic pandemic NN cord-257258-hu9oxea1 74 8 speed speed NN cord-257258-hu9oxea1 74 9 World World NNP cord-257258-hu9oxea1 74 10 Health Health NNP cord-257258-hu9oxea1 74 11 Organization Organization NNP cord-257258-hu9oxea1 74 12 . . . cord-257258-hu9oxea1 75 1 Draft draft NN cord-257258-hu9oxea1 75 2 landscape landscape NN cord-257258-hu9oxea1 75 3 of of IN cord-257258-hu9oxea1 75 4 COVID-19 covid-19 JJ cord-257258-hu9oxea1 75 5 candidate candidate NN cord-257258-hu9oxea1 75 6 vaccines vaccine NNS cord-257258-hu9oxea1 75 7 Hydroxychloroquine Hydroxychloroquine NNP cord-257258-hu9oxea1 75 8 and and CC cord-257258-hu9oxea1 75 9 azithromycin azithromycin NNP cord-257258-hu9oxea1 75 10 as as IN cord-257258-hu9oxea1 75 11 a a DT cord-257258-hu9oxea1 75 12 treatment treatment NN cord-257258-hu9oxea1 75 13 of of IN cord-257258-hu9oxea1 75 14 COVID-19 covid-19 NN cord-257258-hu9oxea1 75 15 : : : cord-257258-hu9oxea1 75 16 Results result NNS cord-257258-hu9oxea1 75 17 of of IN cord-257258-hu9oxea1 75 18 an an DT cord-257258-hu9oxea1 75 19 open open JJ cord-257258-hu9oxea1 75 20 - - HYPH cord-257258-hu9oxea1 75 21 label label NN cord-257258-hu9oxea1 75 22 non non JJ cord-257258-hu9oxea1 75 23 - - JJ cord-257258-hu9oxea1 75 24 randomized randomized JJ cord-257258-hu9oxea1 75 25 clinical clinical JJ cord-257258-hu9oxea1 75 26 trial trial NN cord-257258-hu9oxea1 75 27 International International NNP cord-257258-hu9oxea1 75 28 Society Society NNP cord-257258-hu9oxea1 75 29 of of IN cord-257258-hu9oxea1 75 30 Antimicrobial Antimicrobial NNP cord-257258-hu9oxea1 75 31 Chemotherapy Chemotherapy NNP cord-257258-hu9oxea1 75 32 Statement Statement NNP cord-257258-hu9oxea1 75 33 on on IN cord-257258-hu9oxea1 75 34 IJAA IJAA NNP cord-257258-hu9oxea1 75 35 paper paper NN cord-257258-hu9oxea1 75 36 World World NNP cord-257258-hu9oxea1 75 37 Health Health NNP cord-257258-hu9oxea1 75 38 Organization Organization NNP cord-257258-hu9oxea1 75 39 . . . cord-257258-hu9oxea1 76 1 R R NNP cord-257258-hu9oxea1 76 2 & & CC cord-257258-hu9oxea1 76 3 D D NNP cord-257258-hu9oxea1 76 4 blueprint blueprint NN cord-257258-hu9oxea1 76 5 : : : cord-257258-hu9oxea1 77 1 Informal informal JJ cord-257258-hu9oxea1 77 2 consultation consultation NN cord-257258-hu9oxea1 77 3 on on IN cord-257258-hu9oxea1 77 4 prioritization prioritization NN cord-257258-hu9oxea1 77 5 of of IN cord-257258-hu9oxea1 77 6 candidate candidate NN cord-257258-hu9oxea1 77 7 therapeutic therapeutic JJ cord-257258-hu9oxea1 77 8 agents agent NNS cord-257258-hu9oxea1 77 9 for for IN cord-257258-hu9oxea1 77 10 use use NN cord-257258-hu9oxea1 77 11 in in IN cord-257258-hu9oxea1 77 12 novel novel JJ cord-257258-hu9oxea1 77 13 coronavirus coronavirus NN cord-257258-hu9oxea1 77 14 2019 2019 CD cord-257258-hu9oxea1 77 15 infection infection NN cord-257258-hu9oxea1 77 16 Compassionate compassionate JJ cord-257258-hu9oxea1 77 17 use use NN cord-257258-hu9oxea1 77 18 of of IN cord-257258-hu9oxea1 77 19 remdesivir remdesivir NNS cord-257258-hu9oxea1 77 20 for for IN cord-257258-hu9oxea1 77 21 patients patient NNS cord-257258-hu9oxea1 77 22 with with IN cord-257258-hu9oxea1 77 23 severe severe JJ cord-257258-hu9oxea1 77 24 COVID-19 COVID-19 NNP cord-257258-hu9oxea1 77 25 Hydroxychloroquine Hydroxychloroquine NNP cord-257258-hu9oxea1 77 26 , , , cord-257258-hu9oxea1 77 27 a a DT cord-257258-hu9oxea1 77 28 less less RBR cord-257258-hu9oxea1 77 29 toxic toxic JJ cord-257258-hu9oxea1 77 30 derivative derivative NN cord-257258-hu9oxea1 77 31 of of IN cord-257258-hu9oxea1 77 32 chloroquine chloroquine NN cord-257258-hu9oxea1 77 33 , , , cord-257258-hu9oxea1 77 34 is be VBZ cord-257258-hu9oxea1 77 35 effective effective JJ cord-257258-hu9oxea1 77 36 in in IN cord-257258-hu9oxea1 77 37 inhibiting inhibit VBG cord-257258-hu9oxea1 77 38 SARS SARS NNP cord-257258-hu9oxea1 77 39 - - HYPH cord-257258-hu9oxea1 77 40 CoV-2 CoV-2 NNP cord-257258-hu9oxea1 77 41 infection infection NN cord-257258-hu9oxea1 77 42 in in IN cord-257258-hu9oxea1 77 43 vitro vitro FW cord-257258-hu9oxea1 78 1 An an DT cord-257258-hu9oxea1 78 2 orally orally RB cord-257258-hu9oxea1 78 3 bioavailable bioavailable JJ cord-257258-hu9oxea1 78 4 broad broad JJ cord-257258-hu9oxea1 78 5 spectrum spectrum NN cord-257258-hu9oxea1 78 6 antiviral antiviral NN cord-257258-hu9oxea1 78 7 inhibits inhibit VBZ cord-257258-hu9oxea1 78 8 SARS SARS NNP cord-257258-hu9oxea1 78 9 - - HYPH cord-257258-hu9oxea1 78 10 CoV-2 CoV-2 NNP cord-257258-hu9oxea1 78 11 in in IN cord-257258-hu9oxea1 78 12 human human JJ cord-257258-hu9oxea1 78 13 airway airway NN cord-257258-hu9oxea1 78 14 epithelial epithelial JJ cord-257258-hu9oxea1 78 15 cell cell NN cord-257258-hu9oxea1 78 16 cultures culture NNS cord-257258-hu9oxea1 78 17 and and CC cord-257258-hu9oxea1 78 18 multiple multiple JJ cord-257258-hu9oxea1 78 19 coronaviruses coronaviruse NNS cord-257258-hu9oxea1 78 20 in in IN cord-257258-hu9oxea1 78 21 mice mouse NNS cord-257258-hu9oxea1 79 1 Are be VBP cord-257258-hu9oxea1 79 2 IL-6 IL-6 NNP cord-257258-hu9oxea1 79 3 inhibitors inhibitor NNS cord-257258-hu9oxea1 79 4 one one CD cord-257258-hu9oxea1 79 5 key key NN cord-257258-hu9oxea1 79 6 to to IN cord-257258-hu9oxea1 79 7 COVID-19 covid-19 VB cord-257258-hu9oxea1 79 8 ? ? . cord-257258-hu9oxea1 80 1 EUSA EUSA NNP cord-257258-hu9oxea1 80 2 Pharma Pharma NNP cord-257258-hu9oxea1 80 3 joins join VBZ cord-257258-hu9oxea1 80 4 Sanofi Sanofi NNP cord-257258-hu9oxea1 80 5 , , , cord-257258-hu9oxea1 80 6 Regeneron Regeneron NNP cord-257258-hu9oxea1 80 7 in in IN cord-257258-hu9oxea1 80 8 rolling roll VBG cord-257258-hu9oxea1 80 9 out out RP cord-257258-hu9oxea1 80 10 trials trial NNS cord-257258-hu9oxea1 80 11 Treatment Treatment NNP cord-257258-hu9oxea1 80 12 of of IN cord-257258-hu9oxea1 80 13 5 5 CD cord-257258-hu9oxea1 80 14 critically critically RB cord-257258-hu9oxea1 80 15 ill ill JJ cord-257258-hu9oxea1 80 16 patients patient NNS cord-257258-hu9oxea1 80 17 with with IN cord-257258-hu9oxea1 80 18 COVID-19 COVID-19 NNP cord-257258-hu9oxea1 80 19 with with IN cord-257258-hu9oxea1 80 20 convalescent convalescent JJ cord-257258-hu9oxea1 80 21 plasma plasma NN