id sid tid token lemma pos cord-255908-gcttlpxm 1 1 key key NN cord-255908-gcttlpxm 1 2 : : : cord-255908-gcttlpxm 1 3 cord-255908-gcttlpxm cord-255908-gcttlpxm NNP cord-255908-gcttlpxm 2 1 authors author NNS cord-255908-gcttlpxm 2 2 : : : cord-255908-gcttlpxm 2 3 Kiprov Kiprov NNP cord-255908-gcttlpxm 2 4 , , , cord-255908-gcttlpxm 2 5 Dobri Dobri NNP cord-255908-gcttlpxm 2 6 ; ; : cord-255908-gcttlpxm 2 7 Conboy Conboy NNP cord-255908-gcttlpxm 2 8 , , , cord-255908-gcttlpxm 2 9 Michael Michael NNP cord-255908-gcttlpxm 2 10 J. J. NNP cord-255908-gcttlpxm 2 11 ; ; : cord-255908-gcttlpxm 2 12 Conboy Conboy NNP cord-255908-gcttlpxm 2 13 , , , cord-255908-gcttlpxm 2 14 Irina Irina NNP cord-255908-gcttlpxm 2 15 M. M. NNP cord-255908-gcttlpxm 2 16 title title NN cord-255908-gcttlpxm 2 17 : : : cord-255908-gcttlpxm 2 18 Immunomodulation Immunomodulation NNP cord-255908-gcttlpxm 2 19 for for IN cord-255908-gcttlpxm 2 20 the the DT cord-255908-gcttlpxm 2 21 Management Management NNP cord-255908-gcttlpxm 2 22 of of IN cord-255908-gcttlpxm 2 23 Corona Corona NNP cord-255908-gcttlpxm 2 24 Virus Virus NNP cord-255908-gcttlpxm 2 25 Disease Disease NNP cord-255908-gcttlpxm 2 26 ( ( -LRB- cord-255908-gcttlpxm 2 27 COVID-19 COVID-19 NNP cord-255908-gcttlpxm 2 28 ) ) -RRB- cord-255908-gcttlpxm 2 29 date date NN cord-255908-gcttlpxm 2 30 : : : cord-255908-gcttlpxm 2 31 2020 2020 CD cord-255908-gcttlpxm 2 32 - - HYPH cord-255908-gcttlpxm 2 33 06 06 CD cord-255908-gcttlpxm 2 34 - - SYM cord-255908-gcttlpxm 2 35 27 27 CD cord-255908-gcttlpxm 2 36 journal journal NN cord-255908-gcttlpxm 2 37 : : : cord-255908-gcttlpxm 3 1 Transfus Transfus NNP cord-255908-gcttlpxm 3 2 Apher Apher NNP cord-255908-gcttlpxm 3 3 Sci Sci NNP cord-255908-gcttlpxm 3 4 DOI DOI NNP cord-255908-gcttlpxm 3 5 : : : cord-255908-gcttlpxm 3 6 10.1016 10.1016 CD cord-255908-gcttlpxm 3 7 / / SYM cord-255908-gcttlpxm 3 8 j.transci.2020.102856 j.transci.2020.102856 NNP cord-255908-gcttlpxm 3 9 sha sha NNP cord-255908-gcttlpxm 3 10 : : : cord-255908-gcttlpxm 3 11 760ba0aa8afa7b51cbfa60bb1b7eef1ecea3546f 760ba0aa8afa7b51cbfa60bb1b7eef1ecea3546f NNP cord-255908-gcttlpxm 3 12 doc_id doc_id NNPS cord-255908-gcttlpxm 3 13 : : : cord-255908-gcttlpxm 3 14 255908 255908 CD cord-255908-gcttlpxm 3 15 cord_uid cord_uid NNS cord-255908-gcttlpxm 3 16 : : : cord-255908-gcttlpxm 4 1 gcttlpxm gcttlpxm NNP cord-255908-gcttlpxm 4 2 nan nan NNP cord-255908-gcttlpxm 5 1 This this DT cord-255908-gcttlpxm 5 2 is be VBZ cord-255908-gcttlpxm 5 3 a a DT cord-255908-gcttlpxm 5 4 PDF PDF NNP cord-255908-gcttlpxm 5 5 file file NN cord-255908-gcttlpxm 5 6 of of IN cord-255908-gcttlpxm 5 7 an an DT cord-255908-gcttlpxm 5 8 article article NN cord-255908-gcttlpxm 5 9 that that WDT cord-255908-gcttlpxm 5 10 has have VBZ cord-255908-gcttlpxm 5 11 undergone undergo VBN cord-255908-gcttlpxm 5 12 enhancements enhancement NNS cord-255908-gcttlpxm 5 13 after after IN cord-255908-gcttlpxm 5 14 acceptance acceptance NN cord-255908-gcttlpxm 5 15 , , , cord-255908-gcttlpxm 5 16 such such JJ cord-255908-gcttlpxm 5 17 as as IN cord-255908-gcttlpxm 5 18 the the DT cord-255908-gcttlpxm 5 19 addition addition NN cord-255908-gcttlpxm 5 20 of of IN cord-255908-gcttlpxm 5 21 a a DT cord-255908-gcttlpxm 5 22 cover cover NN cord-255908-gcttlpxm 5 23 page page NN cord-255908-gcttlpxm 5 24 and and CC cord-255908-gcttlpxm 5 25 metadata metadata NN cord-255908-gcttlpxm 5 26 , , , cord-255908-gcttlpxm 5 27 and and CC cord-255908-gcttlpxm 5 28 formatting format VBG cord-255908-gcttlpxm 5 29 for for IN cord-255908-gcttlpxm 5 30 readability readability NN cord-255908-gcttlpxm 5 31 , , , cord-255908-gcttlpxm 5 32 but but CC cord-255908-gcttlpxm 5 33 it -PRON- PRP cord-255908-gcttlpxm 5 34 is be VBZ cord-255908-gcttlpxm 5 35 not not RB cord-255908-gcttlpxm 5 36 yet yet RB cord-255908-gcttlpxm 5 37 the the DT cord-255908-gcttlpxm 5 38 definitive definitive JJ cord-255908-gcttlpxm 5 39 version version NN cord-255908-gcttlpxm 5 40 of of IN cord-255908-gcttlpxm 5 41 record record NN cord-255908-gcttlpxm 5 42 . . . cord-255908-gcttlpxm 6 1 This this DT cord-255908-gcttlpxm 6 2 version version NN cord-255908-gcttlpxm 6 3 will will MD cord-255908-gcttlpxm 6 4 undergo undergo VB cord-255908-gcttlpxm 6 5 additional additional JJ cord-255908-gcttlpxm 6 6 copyediting copyediting NN cord-255908-gcttlpxm 6 7 , , , cord-255908-gcttlpxm 6 8 typesetting typesetting NN cord-255908-gcttlpxm 6 9 and and CC cord-255908-gcttlpxm 6 10 review review NN cord-255908-gcttlpxm 6 11 before before IN cord-255908-gcttlpxm 6 12 it -PRON- PRP cord-255908-gcttlpxm 6 13 is be VBZ cord-255908-gcttlpxm 6 14 published publish VBN cord-255908-gcttlpxm 6 15 in in IN cord-255908-gcttlpxm 6 16 its -PRON- PRP$ cord-255908-gcttlpxm 6 17 final final JJ cord-255908-gcttlpxm 6 18 form form NN cord-255908-gcttlpxm 6 19 , , , cord-255908-gcttlpxm 6 20 but but CC cord-255908-gcttlpxm 6 21 we -PRON- PRP cord-255908-gcttlpxm 6 22 are be VBP cord-255908-gcttlpxm 6 23 providing provide VBG cord-255908-gcttlpxm 6 24 this this DT cord-255908-gcttlpxm 6 25 version version NN cord-255908-gcttlpxm 6 26 to to TO cord-255908-gcttlpxm 6 27 give give VB cord-255908-gcttlpxm 6 28 early early JJ cord-255908-gcttlpxm 6 29 visibility visibility NN cord-255908-gcttlpxm 6 30 of of IN cord-255908-gcttlpxm 6 31 the the DT cord-255908-gcttlpxm 6 32 article article NN cord-255908-gcttlpxm 6 33 . . . cord-255908-gcttlpxm 7 1 Please please UH cord-255908-gcttlpxm 7 2 note note VB cord-255908-gcttlpxm 7 3 that that IN cord-255908-gcttlpxm 7 4 , , , cord-255908-gcttlpxm 7 5 during during IN cord-255908-gcttlpxm 7 6 the the DT cord-255908-gcttlpxm 7 7 production production NN cord-255908-gcttlpxm 7 8 process process NN cord-255908-gcttlpxm 7 9 , , , cord-255908-gcttlpxm 7 10 errors error NNS cord-255908-gcttlpxm 7 11 may may MD cord-255908-gcttlpxm 7 12 be be VB cord-255908-gcttlpxm 7 13 discovered discover VBN cord-255908-gcttlpxm 7 14 which which WDT cord-255908-gcttlpxm 7 15 could could MD cord-255908-gcttlpxm 7 16 affect affect VB cord-255908-gcttlpxm 7 17 the the DT cord-255908-gcttlpxm 7 18 content content NN cord-255908-gcttlpxm 7 19 , , , cord-255908-gcttlpxm 7 20 and and CC cord-255908-gcttlpxm 7 21 all all DT cord-255908-gcttlpxm 7 22 legal legal JJ cord-255908-gcttlpxm 7 23 disclaimers disclaimer NNS cord-255908-gcttlpxm 7 24 that that WDT cord-255908-gcttlpxm 7 25 apply apply VBP cord-255908-gcttlpxm 7 26 to to IN cord-255908-gcttlpxm 7 27 the the DT cord-255908-gcttlpxm 7 28 journal journal NN cord-255908-gcttlpxm 7 29 pertain pertain VB cord-255908-gcttlpxm 7 30 . . . cord-255908-gcttlpxm 8 1 Dobri Dobri NNP cord-255908-gcttlpxm 8 2 D. D. NNP cord-255908-gcttlpxm 8 3 Kiprov Kiprov NNP cord-255908-gcttlpxm 9 1 Currently currently RB cord-255908-gcttlpxm 9 2 there there EX cord-255908-gcttlpxm 9 3 is be VBZ cord-255908-gcttlpxm 9 4 no no DT cord-255908-gcttlpxm 9 5 vaccine vaccine NN cord-255908-gcttlpxm 9 6 for for IN cord-255908-gcttlpxm 9 7 prophylaxis prophylaxis NN cord-255908-gcttlpxm 9 8 nor nor CC cord-255908-gcttlpxm 9 9 proven prove VBN cord-255908-gcttlpxm 9 10 treatment treatment NN cord-255908-gcttlpxm 9 11 for for IN cord-255908-gcttlpxm 9 12 COVID-19 COVID-19 NNP cord-255908-gcttlpxm 9 13 . . . cord-255908-gcttlpxm 10 1 Immune immune JJ cord-255908-gcttlpxm 10 2 or or CC cord-255908-gcttlpxm 10 3 convalescent convalescent JJ cord-255908-gcttlpxm 10 4 plasma plasma NN cord-255908-gcttlpxm 10 5 collected collect VBN cord-255908-gcttlpxm 10 6 from from IN cord-255908-gcttlpxm 10 7 people people NNS cord-255908-gcttlpxm 10 8 who who WP cord-255908-gcttlpxm 10 9 have have VBP cord-255908-gcttlpxm 10 10 fully fully RB cord-255908-gcttlpxm 10 11 recovered recover VBN cord-255908-gcttlpxm 10 12 from from IN cord-255908-gcttlpxm 10 13 infection infection NN cord-255908-gcttlpxm 10 14 contains contain VBZ cord-255908-gcttlpxm 10 15 antibodies antibody NNS cord-255908-gcttlpxm 10 16 against against IN cord-255908-gcttlpxm 10 17 the the DT cord-255908-gcttlpxm 10 18 infectious infectious JJ cord-255908-gcttlpxm 10 19 agent agent NN cord-255908-gcttlpxm 10 20 . . . cord-255908-gcttlpxm 11 1 Convalescent convalescent JJ cord-255908-gcttlpxm 11 2 plasma plasma NN cord-255908-gcttlpxm 11 3 provides provide VBZ cord-255908-gcttlpxm 11 4 passive passive JJ cord-255908-gcttlpxm 11 5 immunity immunity NN cord-255908-gcttlpxm 11 6 and and CC cord-255908-gcttlpxm 11 7 has have VBZ cord-255908-gcttlpxm 11 8 been be VBN cord-255908-gcttlpxm 11 9 used use VBN cord-255908-gcttlpxm 11 10 for for IN cord-255908-gcttlpxm 11 11 the the DT cord-255908-gcttlpxm 11 12 prophylaxis prophylaxis NN cord-255908-gcttlpxm 11 13 and and CC cord-255908-gcttlpxm 11 14 treatment treatment NN cord-255908-gcttlpxm 11 15 of of IN cord-255908-gcttlpxm 11 16 a a DT cord-255908-gcttlpxm 11 17 number number NN cord-255908-gcttlpxm 11 18 of of IN cord-255908-gcttlpxm 11 19 infectious infectious JJ cord-255908-gcttlpxm 11 20 diseases disease NNS cord-255908-gcttlpxm 11 21 , , , cord-255908-gcttlpxm 11 22 including include VBG cord-255908-gcttlpxm 11 23 recent recent JJ cord-255908-gcttlpxm 11 24 epidemics epidemic NNS cord-255908-gcttlpxm 11 25 with with IN cord-255908-gcttlpxm 11 26 SARS SARS NNP cord-255908-gcttlpxm 11 27 - - HYPH cord-255908-gcttlpxm 11 28 Cov-1 Cov-1 NNP cord-255908-gcttlpxm 11 29 , , , cord-255908-gcttlpxm 11 30 Ebola Ebola NNP cord-255908-gcttlpxm 11 31 and and CC cord-255908-gcttlpxm 11 32 Middle middle JJ cord-255908-gcttlpxm 11 33 Eastern eastern JJ cord-255908-gcttlpxm 11 34 Respiratory Respiratory NNP cord-255908-gcttlpxm 11 35 Syndrome Syndrome NNP cord-255908-gcttlpxm 11 36 ( ( -LRB- cord-255908-gcttlpxm 11 37 MERS MERS NNP cord-255908-gcttlpxm 11 38 ) ) -RRB- cord-255908-gcttlpxm 11 39 . . . cord-255908-gcttlpxm 12 1 1 1 CD cord-255908-gcttlpxm 12 2 Small small JJ cord-255908-gcttlpxm 12 3 studies study NNS cord-255908-gcttlpxm 12 4 from from IN cord-255908-gcttlpxm 12 5 China China NNP cord-255908-gcttlpxm 12 6 have have VBP cord-255908-gcttlpxm 12 7 demonstrated demonstrate VBN cord-255908-gcttlpxm 12 8 that that DT cord-255908-gcttlpxm 12 9 infusion infusion NN cord-255908-gcttlpxm 12 10 of of IN cord-255908-gcttlpxm 12 11 convalescent convalescent JJ cord-255908-gcttlpxm 12 12 plasma plasma NN cord-255908-gcttlpxm 12 13 from from IN cord-255908-gcttlpxm 12 14 people people NNS cord-255908-gcttlpxm 12 15 who who WP cord-255908-gcttlpxm 12 16 have have VBP cord-255908-gcttlpxm 12 17 recovered recover VBN cord-255908-gcttlpxm 12 18 from from IN cord-255908-gcttlpxm 12 19 COVID-19 COVID-19 NNP cord-255908-gcttlpxm 12 20 is be VBZ cord-255908-gcttlpxm 12 21 safe safe JJ cord-255908-gcttlpxm 12 22 and and CC cord-255908-gcttlpxm 12 23 results result NNS cord-255908-gcttlpxm 12 24 in in IN cord-255908-gcttlpxm 12 25 reduction reduction NN cord-255908-gcttlpxm 12 26 of of IN cord-255908-gcttlpxm 12 27 viral viral JJ cord-255908-gcttlpxm 12 28 load load NN cord-255908-gcttlpxm 12 29 and and CC cord-255908-gcttlpxm 12 30 improved improve VBN cord-255908-gcttlpxm 12 31 clinical clinical JJ cord-255908-gcttlpxm 12 32 outcome outcome NN cord-255908-gcttlpxm 12 33 . . . cord-255908-gcttlpxm 13 1 This this DT cord-255908-gcttlpxm 13 2 prompted prompt VBD cord-255908-gcttlpxm 13 3 the the DT cord-255908-gcttlpxm 13 4 FDA FDA NNP cord-255908-gcttlpxm 13 5 to to TO cord-255908-gcttlpxm 13 6 allow allow VB cord-255908-gcttlpxm 13 7 the the DT cord-255908-gcttlpxm 13 8 use use NN cord-255908-gcttlpxm 13 9 of of IN cord-255908-gcttlpxm 13 10 convalescent convalescent JJ cord-255908-gcttlpxm 13 11 plasma plasma NN cord-255908-gcttlpxm 13 12 in in IN cord-255908-gcttlpxm 13 13 patients patient NNS cord-255908-gcttlpxm 13 14 with with IN cord-255908-gcttlpxm 13 15 COVID-19 COVID-19 NNP cord-255908-gcttlpxm 13 16 . . NNP cord-255908-gcttlpxm 13 17 1 1 CD cord-255908-gcttlpxm 14 1 The the DT cord-255908-gcttlpxm 14 2 proposed propose VBN cord-255908-gcttlpxm 14 3 infusion infusion NN cord-255908-gcttlpxm 14 4 dose dose NN cord-255908-gcttlpxm 14 5 is be VBZ cord-255908-gcttlpxm 14 6 200 200 CD cord-255908-gcttlpxm 14 7 ml ml NNS cord-255908-gcttlpxm 14 8 of of IN cord-255908-gcttlpxm 14 9 plasma plasma NN cord-255908-gcttlpxm 14 10 . . . cord-255908-gcttlpxm 15 1 However however RB cord-255908-gcttlpxm 15 2 , , , cord-255908-gcttlpxm 15 3 this this DT cord-255908-gcttlpxm 15 4 is be VBZ cord-255908-gcttlpxm 15 5 based base VBN cord-255908-gcttlpxm 15 6 on on IN cord-255908-gcttlpxm 15 7 the the DT cord-255908-gcttlpxm 15 8 Chinese chinese JJ cord-255908-gcttlpxm 15 9 experience experience NN cord-255908-gcttlpxm 15 10 alone alone RB cord-255908-gcttlpxm 15 11 and and CC cord-255908-gcttlpxm 15 12 deserves deserve VBZ cord-255908-gcttlpxm 15 13 further further JJ cord-255908-gcttlpxm 15 14 study study NN cord-255908-gcttlpxm 15 15 . . . cord-255908-gcttlpxm 16 1 Older old JJR cord-255908-gcttlpxm 16 2 adults adult NNS cord-255908-gcttlpxm 16 3 and and CC cord-255908-gcttlpxm 16 4 people people NNS cord-255908-gcttlpxm 16 5 with with IN cord-255908-gcttlpxm 16 6 severe severe JJ cord-255908-gcttlpxm 16 7 underlying underlying JJ cord-255908-gcttlpxm 16 8 conditions condition NNS cord-255908-gcttlpxm 16 9 are be VBP cord-255908-gcttlpxm 16 10 at at IN cord-255908-gcttlpxm 16 11 higher high JJR cord-255908-gcttlpxm 16 12 risk risk NN cord-255908-gcttlpxm 16 13 for for IN cord-255908-gcttlpxm 16 14 developing develop VBG cord-255908-gcttlpxm 16 15 more more RBR cord-255908-gcttlpxm 16 16 serious serious JJ cord-255908-gcttlpxm 16 17 complications complication NNS cord-255908-gcttlpxm 16 18 from from IN cord-255908-gcttlpxm 16 19 COVID-19 covid-19 NN cord-255908-gcttlpxm 16 20 and and CC cord-255908-gcttlpxm 16 21 account account VB cord-255908-gcttlpxm 16 22 for for IN cord-255908-gcttlpxm 16 23 the the DT cord-255908-gcttlpxm 16 24 majority majority NN cord-255908-gcttlpxm 16 25 of of IN cord-255908-gcttlpxm 16 26 the the DT cord-255908-gcttlpxm 16 27 deaths death NNS cord-255908-gcttlpxm 16 28 . . . cord-255908-gcttlpxm 17 1 Systemic systemic JJ cord-255908-gcttlpxm 17 2 chronic chronic JJ cord-255908-gcttlpxm 17 3 inflammation inflammation NN cord-255908-gcttlpxm 17 4 is be VBZ cord-255908-gcttlpxm 17 5 believed believe VBN cord-255908-gcttlpxm 17 6 to to TO cord-255908-gcttlpxm 17 7 be be VB cord-255908-gcttlpxm 17 8 the the DT cord-255908-gcttlpxm 17 9 major major JJ cord-255908-gcttlpxm 17 10 cause cause NN cord-255908-gcttlpxm 17 11 of of IN cord-255908-gcttlpxm 17 12 immunosenescence immunosenescence NN cord-255908-gcttlpxm 17 13 . . . cord-255908-gcttlpxm 18 1 A a DT cord-255908-gcttlpxm 18 2 prominent prominent JJ cord-255908-gcttlpxm 18 3 feature feature NN cord-255908-gcttlpxm 18 4 of of IN cord-255908-gcttlpxm 18 5 the the DT cord-255908-gcttlpxm 18 6 aging age VBG cord-255908-gcttlpxm 18 7 phenotype phenotype NN cord-255908-gcttlpxm 18 8 is be VBZ cord-255908-gcttlpxm 18 9 increased increase VBN cord-255908-gcttlpxm 18 10 secretion secretion NN cord-255908-gcttlpxm 18 11 of of IN cord-255908-gcttlpxm 18 12 proinflammatory proinflammatory JJ cord-255908-gcttlpxm 18 13 cytokines cytokine NNS cord-255908-gcttlpxm 18 14 which which WDT cord-255908-gcttlpxm 18 15 may may MD cord-255908-gcttlpxm 18 16 contribute contribute VB cord-255908-gcttlpxm 18 17 to to IN cord-255908-gcttlpxm 18 18 the the DT cord-255908-gcttlpxm 18 19 cytokine cytokine NN cord-255908-gcttlpxm 18 20 storm storm NN cord-255908-gcttlpxm 18 21 seen see VBN cord-255908-gcttlpxm 18 22 in in IN cord-255908-gcttlpxm 18 23 COVID-19 COVID-19 NNP cord-255908-gcttlpxm 18 24 . . . cord-255908-gcttlpxm 19 1 Older old JJR cord-255908-gcttlpxm 19 2 adults adult NNS cord-255908-gcttlpxm 19 3 experience experience VBP cord-255908-gcttlpxm 19 4 down down IN cord-255908-gcttlpxm 19 5 regulation regulation NN cord-255908-gcttlpxm 19 6 of of IN cord-255908-gcttlpxm 19 7 the the DT cord-255908-gcttlpxm 19 8 immune immune JJ cord-255908-gcttlpxm 19 9 response response NN cord-255908-gcttlpxm 19 10 that that WDT cord-255908-gcttlpxm 19 11 leads lead VBZ cord-255908-gcttlpxm 19 12 to to IN cord-255908-gcttlpxm 19 13 an an DT cord-255908-gcttlpxm 19 14 increased increase VBN cord-255908-gcttlpxm 19 15 susceptibility susceptibility NN cord-255908-gcttlpxm 19 16 to to IN cord-255908-gcttlpxm 19 17 viral viral JJ cord-255908-gcttlpxm 19 18 infections infection NNS cord-255908-gcttlpxm 19 19 and and CC cord-255908-gcttlpxm 19 20 weakened weaken VBN cord-255908-gcttlpxm 19 21 response response NN cord-255908-gcttlpxm 19 22 to to IN cord-255908-gcttlpxm 19 23 vaccines vaccine NNS cord-255908-gcttlpxm 19 24 . . . cord-255908-gcttlpxm 20 1 Collateral collateral JJ cord-255908-gcttlpxm 20 2 damage damage NN cord-255908-gcttlpxm 20 3 from from IN cord-255908-gcttlpxm 20 4 chronic chronic JJ cord-255908-gcttlpxm 20 5 inflammation inflammation NN cord-255908-gcttlpxm 20 6 is be VBZ cord-255908-gcttlpxm 20 7 oxidative oxidative JJ cord-255908-gcttlpxm 20 8 stress stress NN cord-255908-gcttlpxm 20 9 . . . cord-255908-gcttlpxm 21 1 2 2 LS cord-255908-gcttlpxm 21 2 Experimental experimental JJ cord-255908-gcttlpxm 21 3 studies study NNS cord-255908-gcttlpxm 21 4 in in IN cord-255908-gcttlpxm 21 5 rodents rodent NNS cord-255908-gcttlpxm 21 6 using use VBG cord-255908-gcttlpxm 21 7 parabiosis parabiosis NN cord-255908-gcttlpxm 21 8 and and CC cord-255908-gcttlpxm 21 9 blood blood NN cord-255908-gcttlpxm 21 10 exchange exchange NN cord-255908-gcttlpxm 21 11 models model NNS cord-255908-gcttlpxm 21 12 have have VBP cord-255908-gcttlpxm 21 13 demonstrated demonstrate VBN cord-255908-gcttlpxm 21 14 that that IN cord-255908-gcttlpxm 21 15 the the DT cord-255908-gcttlpxm 21 16 removal removal NN cord-255908-gcttlpxm 21 17 of of IN cord-255908-gcttlpxm 21 18 proinflammatory proinflammatory JJ cord-255908-gcttlpxm 21 19 substances substance NNS cord-255908-gcttlpxm 21 20 from from IN cord-255908-gcttlpxm 21 21 the the DT cord-255908-gcttlpxm 21 22 circulation circulation NN cord-255908-gcttlpxm 21 23 of of IN cord-255908-gcttlpxm 21 24 old old JJ cord-255908-gcttlpxm 21 25 mice mouse NNS cord-255908-gcttlpxm 21 26 leads lead VBZ cord-255908-gcttlpxm 21 27 to to IN cord-255908-gcttlpxm 21 28 a a DT cord-255908-gcttlpxm 21 29 rapid rapid JJ cord-255908-gcttlpxm 21 30 and and CC cord-255908-gcttlpxm 21 31 robust robust JJ cord-255908-gcttlpxm 21 32 rejuvenation rejuvenation NN cord-255908-gcttlpxm 21 33 of of IN cord-255908-gcttlpxm 21 34 multiple multiple JJ cord-255908-gcttlpxm 21 35 organs organ NNS cord-255908-gcttlpxm 21 36 . . . cord-255908-gcttlpxm 22 1 3 3 LS cord-255908-gcttlpxm 23 1 Since since IN cord-255908-gcttlpxm 23 2 parabiosis parabiosis NN cord-255908-gcttlpxm 23 3 is be VBZ cord-255908-gcttlpxm 23 4 not not RB cord-255908-gcttlpxm 23 5 possible possible JJ cord-255908-gcttlpxm 23 6 in in IN cord-255908-gcttlpxm 23 7 humans human NNS cord-255908-gcttlpxm 23 8 , , , cord-255908-gcttlpxm 23 9 therapeutic therapeutic JJ cord-255908-gcttlpxm 23 10 plasma plasma NN cord-255908-gcttlpxm 23 11 exchange exchange NN cord-255908-gcttlpxm 23 12 , , , cord-255908-gcttlpxm 23 13 ( ( -LRB- cord-255908-gcttlpxm 23 14 TPE TPE NNP cord-255908-gcttlpxm 23 15 ) ) -RRB- cord-255908-gcttlpxm 23 16 has have VBZ cord-255908-gcttlpxm 23 17 been be VBN cord-255908-gcttlpxm 23 18 proposed propose VBN cord-255908-gcttlpxm 23 19 as as IN cord-255908-gcttlpxm 23 20 an an DT cord-255908-gcttlpxm 23 21 alternative alternative NN cord-255908-gcttlpxm 23 22 because because IN cord-255908-gcttlpxm 23 23 it -PRON- PRP cord-255908-gcttlpxm 23 24 has have VBZ cord-255908-gcttlpxm 23 25 a a DT cord-255908-gcttlpxm 23 26 multifaceted multifacete VBN cord-255908-gcttlpxm 23 27 immunomodulatory immunomodulatory JJ cord-255908-gcttlpxm 23 28 effect effect NN cord-255908-gcttlpxm 23 29 . . . cord-255908-gcttlpxm 24 1 4 4 LS cord-255908-gcttlpxm 25 1 TPE TPE NNP cord-255908-gcttlpxm 25 2 has have VBZ cord-255908-gcttlpxm 25 3 been be VBN cord-255908-gcttlpxm 25 4 shown show VBN cord-255908-gcttlpxm 25 5 in in IN cord-255908-gcttlpxm 25 6 randomized randomized JJ cord-255908-gcttlpxm 25 7 and and CC cord-255908-gcttlpxm 25 8 nonrandomized nonrandomized JJ cord-255908-gcttlpxm 25 9 clinical clinical JJ cord-255908-gcttlpxm 25 10 trials trial NNS cord-255908-gcttlpxm 25 11 to to TO cord-255908-gcttlpxm 25 12 have have VB cord-255908-gcttlpxm 25 13 a a DT cord-255908-gcttlpxm 25 14 beneficial beneficial JJ cord-255908-gcttlpxm 25 15 effect effect NN cord-255908-gcttlpxm 25 16 in in IN cord-255908-gcttlpxm 25 17 sepsis sepsis NN cord-255908-gcttlpxm 25 18 associated associate VBN cord-255908-gcttlpxm 25 19 with with IN cord-255908-gcttlpxm 25 20 severe severe JJ cord-255908-gcttlpxm 25 21 inflammatory inflammatory JJ cord-255908-gcttlpxm 25 22 response response NN cord-255908-gcttlpxm 25 23 syndrome syndrome NN cord-255908-gcttlpxm 25 24 ( ( -LRB- cord-255908-gcttlpxm 25 25 SIRS SIRS NNP cord-255908-gcttlpxm 25 26 ) ) -RRB- cord-255908-gcttlpxm 25 27 . . . cord-255908-gcttlpxm 26 1 5 5 LS cord-255908-gcttlpxm 27 1 And and CC cord-255908-gcttlpxm 27 2 recently recently RB cord-255908-gcttlpxm 27 3 , , , cord-255908-gcttlpxm 27 4 TPE TPE NNP cord-255908-gcttlpxm 27 5 has have VBZ cord-255908-gcttlpxm 27 6 been be VBN cord-255908-gcttlpxm 27 7 successfully successfully RB cord-255908-gcttlpxm 27 8 used use VBN cord-255908-gcttlpxm 27 9 in in IN cord-255908-gcttlpxm 27 10 the the DT cord-255908-gcttlpxm 27 11 treatment treatment NN cord-255908-gcttlpxm 27 12 of of IN cord-255908-gcttlpxm 27 13 severe severe JJ cord-255908-gcttlpxm 27 14 cytokine cytokine NN cord-255908-gcttlpxm 27 15 release release NN cord-255908-gcttlpxm 27 16 syndrome syndrome NN cord-255908-gcttlpxm 27 17 after after IN cord-255908-gcttlpxm 27 18 Chimera Chimera NNP cord-255908-gcttlpxm 27 19 Antigen Antigen NNP cord-255908-gcttlpxm 27 20 Receptor Receptor NNP cord-255908-gcttlpxm 27 21 T T NNP cord-255908-gcttlpxm 27 22 cell cell NN cord-255908-gcttlpxm 27 23 ( ( -LRB- cord-255908-gcttlpxm 27 24 CAR CAR NNP cord-255908-gcttlpxm 27 25 - - HYPH cord-255908-gcttlpxm 27 26 T t NN cord-255908-gcttlpxm 27 27 ) ) -RRB- cord-255908-gcttlpxm 27 28 infusion infusion NN cord-255908-gcttlpxm 27 29 . . . cord-255908-gcttlpxm 28 1 TPE TPE NNP cord-255908-gcttlpxm 28 2 with with IN cord-255908-gcttlpxm 28 3 5 5 CD cord-255908-gcttlpxm 28 4 % % NN cord-255908-gcttlpxm 28 5 albumin albumin NN cord-255908-gcttlpxm 28 6 replacement replacement NN cord-255908-gcttlpxm 28 7 also also RB cord-255908-gcttlpxm 28 8 provides provide VBZ cord-255908-gcttlpxm 28 9 a a DT cord-255908-gcttlpxm 28 10 significant significant JJ cord-255908-gcttlpxm 28 11 antioxidant antioxidant NN cord-255908-gcttlpxm 28 12 boost boost NN cord-255908-gcttlpxm 28 13 . . . cord-255908-gcttlpxm 29 1 5 5 LS cord-255908-gcttlpxm 30 1 We -PRON- PRP cord-255908-gcttlpxm 30 2 believe believe VBP cord-255908-gcttlpxm 30 3 that that IN cord-255908-gcttlpxm 30 4 TPE TPE NNP cord-255908-gcttlpxm 30 5 with with IN cord-255908-gcttlpxm 30 6 a a DT cord-255908-gcttlpxm 30 7 combination combination NN cord-255908-gcttlpxm 30 8 of of IN cord-255908-gcttlpxm 30 9 5 5 CD cord-255908-gcttlpxm 30 10 % % NN cord-255908-gcttlpxm 30 11 albumin albumin NN cord-255908-gcttlpxm 30 12 and and CC cord-255908-gcttlpxm 30 13 convalescent convalescent JJ cord-255908-gcttlpxm 30 14 plasma plasma NN cord-255908-gcttlpxm 30 15 replacement replacement NN cord-255908-gcttlpxm 30 16 at at IN cord-255908-gcttlpxm 30 17 the the DT cord-255908-gcttlpxm 30 18 end end NN cord-255908-gcttlpxm 30 19 of of IN cord-255908-gcttlpxm 30 20 the the DT cord-255908-gcttlpxm 30 21 procedure procedure NN cord-255908-gcttlpxm 30 22 can can MD cord-255908-gcttlpxm 30 23 be be VB cord-255908-gcttlpxm 30 24 a a DT cord-255908-gcttlpxm 30 25 valuable valuable JJ cord-255908-gcttlpxm 30 26 treatment treatment NN cord-255908-gcttlpxm 30 27 option option NN cord-255908-gcttlpxm 30 28 for for IN cord-255908-gcttlpxm 30 29 COVID-19 covid-19 JJ cord-255908-gcttlpxm 30 30 patients patient NNS cord-255908-gcttlpxm 30 31 and and CC cord-255908-gcttlpxm 30 32 warrants warrant VBZ cord-255908-gcttlpxm 30 33 a a DT cord-255908-gcttlpxm 30 34 comparison comparison NN cord-255908-gcttlpxm 30 35 trial trial NN cord-255908-gcttlpxm 30 36 with with IN cord-255908-gcttlpxm 30 37 simple simple JJ cord-255908-gcttlpxm 30 38 convalescent convalescent JJ cord-255908-gcttlpxm 30 39 plasma plasma NN cord-255908-gcttlpxm 30 40 infusion infusion NN cord-255908-gcttlpxm 30 41 . . . cord-255908-gcttlpxm 31 1 Deployment deployment NN cord-255908-gcttlpxm 31 2 of of IN cord-255908-gcttlpxm 31 3 convalescent convalescent JJ cord-255908-gcttlpxm 31 4 plasma plasma NN cord-255908-gcttlpxm 31 5 for for IN cord-255908-gcttlpxm 31 6 the the DT cord-255908-gcttlpxm 31 7 prevention prevention NN cord-255908-gcttlpxm 31 8 and and CC cord-255908-gcttlpxm 31 9 treatment treatment NN cord-255908-gcttlpxm 31 10 of of IN cord-255908-gcttlpxm 31 11 COVID-19 COVID-19 NNP cord-255908-gcttlpxm 31 12 Covid-19 Covid-19 NNP cord-255908-gcttlpxm 31 13 and and CC cord-255908-gcttlpxm 31 14 Immunity Immunity NNP cord-255908-gcttlpxm 31 15 in in IN cord-255908-gcttlpxm 31 16 Aging age VBG cord-255908-gcttlpxm 31 17 Populations population NNS cord-255908-gcttlpxm 31 18 -A -A . cord-255908-gcttlpxm 32 1 New New NNP cord-255908-gcttlpxm 32 2 Research Research NNP cord-255908-gcttlpxm 32 3 Agenda Agenda NNP cord-255908-gcttlpxm 33 1 A a DT cord-255908-gcttlpxm 33 2 single single JJ cord-255908-gcttlpxm 33 3 heterochronic heterochronic NNP cord-255908-gcttlpxm 33 4 blood blood NN cord-255908-gcttlpxm 33 5 exchange exchange NNP cord-255908-gcttlpxm 33 6 reveals reveal VBZ cord-255908-gcttlpxm 33 7 rapid rapid JJ cord-255908-gcttlpxm 33 8 inhibition inhibition NN cord-255908-gcttlpxm 33 9 of of IN cord-255908-gcttlpxm 33 10 multiple multiple JJ cord-255908-gcttlpxm 33 11 tissues tissue NNS cord-255908-gcttlpxm 33 12 by by IN cord-255908-gcttlpxm 33 13 old old JJ cord-255908-gcttlpxm 33 14 blood blood NN cord-255908-gcttlpxm 33 15 Intermittent Intermittent NNP cord-255908-gcttlpxm 33 16 Heterochronic Heterochronic NNP cord-255908-gcttlpxm 33 17 Plasma Plasma NNP cord-255908-gcttlpxm 33 18 Exchange Exchange NNP cord-255908-gcttlpxm 33 19 as as IN cord-255908-gcttlpxm 33 20 a a DT cord-255908-gcttlpxm 33 21 Modality modality NN cord-255908-gcttlpxm 33 22 for for IN cord-255908-gcttlpxm 33 23 Delaying delay VBG cord-255908-gcttlpxm 33 24 Cellular cellular JJ cord-255908-gcttlpxm 33 25 Senescence senescence NN cord-255908-gcttlpxm 33 26 -A -A . cord-255908-gcttlpxm 34 1 Hypothesis hypothesis NN cord-255908-gcttlpxm 35 1 A a DT cord-255908-gcttlpxm 35 2 novel novel JJ cord-255908-gcttlpxm 35 3 treatment treatment NN cord-255908-gcttlpxm 35 4 approach approach NN cord-255908-gcttlpxm 35 5 to to IN cord-255908-gcttlpxm 35 6 the the DT cord-255908-gcttlpxm 35 7 novel novel JJ cord-255908-gcttlpxm 35 8 coronavirus coronavirus NN cord-255908-gcttlpxm 35 9 : : : cord-255908-gcttlpxm 35 10 an an DT cord-255908-gcttlpxm 35 11 argument argument NN cord-255908-gcttlpxm 35 12 for for IN cord-255908-gcttlpxm 35 13 the the DT cord-255908-gcttlpxm 35 14 use use NN cord-255908-gcttlpxm 35 15 of of IN cord-255908-gcttlpxm 35 16 therapeutic therapeutic JJ cord-255908-gcttlpxm 35 17 plasma plasma NN cord-255908-gcttlpxm 35 18 exchange exchange NN cord-255908-gcttlpxm 35 19 for for IN cord-255908-gcttlpxm 35 20 fulminant fulminant JJ cord-255908-gcttlpxm 35 21 COVID-19 COVID-19 NNP