id sid tid token lemma pos cord-253196-et1ekgdl 1 1 key key JJ cord-253196-et1ekgdl 1 2 : : : cord-253196-et1ekgdl 1 3 cord-253196-et1ekgdl cord-253196-et1ekgdl CD cord-253196-et1ekgdl 1 4 authors author NNS cord-253196-et1ekgdl 1 5 : : : cord-253196-et1ekgdl 1 6 Yazdany Yazdany NNP cord-253196-et1ekgdl 1 7 , , , cord-253196-et1ekgdl 1 8 Jinoos Jinoos NNP cord-253196-et1ekgdl 1 9 ; ; : cord-253196-et1ekgdl 1 10 Kim Kim NNP cord-253196-et1ekgdl 1 11 , , , cord-253196-et1ekgdl 1 12 Alfred Alfred NNP cord-253196-et1ekgdl 1 13 H.J. H.J. NNP cord-253196-et1ekgdl 1 14 title title NN cord-253196-et1ekgdl 1 15 : : : cord-253196-et1ekgdl 1 16 Use Use NNP cord-253196-et1ekgdl 1 17 of of IN cord-253196-et1ekgdl 1 18 Hydroxychloroquine Hydroxychloroquine NNP cord-253196-et1ekgdl 1 19 and and CC cord-253196-et1ekgdl 1 20 Chloroquine Chloroquine NNP cord-253196-et1ekgdl 1 21 During during IN cord-253196-et1ekgdl 1 22 the the DT cord-253196-et1ekgdl 1 23 COVID-19 COVID-19 NNP cord-253196-et1ekgdl 1 24 Pandemic Pandemic NNP cord-253196-et1ekgdl 1 25 : : : cord-253196-et1ekgdl 2 1 What what WP cord-253196-et1ekgdl 2 2 Every every DT cord-253196-et1ekgdl 2 3 Clinician clinician NN cord-253196-et1ekgdl 2 4 Should Should MD cord-253196-et1ekgdl 2 5 Know know VB cord-253196-et1ekgdl 2 6 date date NN cord-253196-et1ekgdl 3 1 : : : cord-253196-et1ekgdl 3 2 2020 2020 CD cord-253196-et1ekgdl 3 3 - - HYPH cord-253196-et1ekgdl 3 4 03 03 CD cord-253196-et1ekgdl 3 5 - - HYPH cord-253196-et1ekgdl 3 6 31 31 CD cord-253196-et1ekgdl 3 7 journal journal NN cord-253196-et1ekgdl 3 8 : : : cord-253196-et1ekgdl 4 1 Ann Ann NNP cord-253196-et1ekgdl 4 2 Intern Intern NNP cord-253196-et1ekgdl 4 3 Med Med NNP cord-253196-et1ekgdl 4 4 DOI DOI NNP cord-253196-et1ekgdl 4 5 : : : cord-253196-et1ekgdl 5 1 10.7326 10.7326 CD cord-253196-et1ekgdl 5 2 / / SYM cord-253196-et1ekgdl 5 3 m20 m20 CD cord-253196-et1ekgdl 5 4 - - SYM cord-253196-et1ekgdl 5 5 1334 1334 CD cord-253196-et1ekgdl 5 6 sha sha NN cord-253196-et1ekgdl 5 7 : : : cord-253196-et1ekgdl 5 8 a6f941a2724e5e6c3d00f3fbc570182f1a8188f4 a6f941a2724e5e6c3d00f3fbc570182f1a8188f4 NNP cord-253196-et1ekgdl 5 9 doc_id doc_id CD cord-253196-et1ekgdl 5 10 : : : cord-253196-et1ekgdl 5 11 253196 253196 CD cord-253196-et1ekgdl 5 12 cord_uid cord_uid NNS cord-253196-et1ekgdl 5 13 : : : cord-253196-et1ekgdl 6 1 et1ekgdl et1ekgdl . cord-253196-et1ekgdl 7 1 Two two CD cord-253196-et1ekgdl 7 2 medications medication NNS cord-253196-et1ekgdl 7 3 often often RB cord-253196-et1ekgdl 7 4 used use VBN cord-253196-et1ekgdl 7 5 for for IN cord-253196-et1ekgdl 7 6 treatment treatment NN cord-253196-et1ekgdl 7 7 of of IN cord-253196-et1ekgdl 7 8 immune immune NN cord-253196-et1ekgdl 7 9 - - HYPH cord-253196-et1ekgdl 7 10 mediated mediate VBN cord-253196-et1ekgdl 7 11 conditions condition NNS cord-253196-et1ekgdl 7 12 , , , cord-253196-et1ekgdl 7 13 hydroxychloroquine hydroxychloroquine NN cord-253196-et1ekgdl 7 14 and and CC cord-253196-et1ekgdl 7 15 chloroquine chloroquine NNP cord-253196-et1ekgdl 7 16 , , , cord-253196-et1ekgdl 7 17 have have VBP cord-253196-et1ekgdl 7 18 recently recently RB cord-253196-et1ekgdl 7 19 attracted attract VBN cord-253196-et1ekgdl 7 20 widespread widespread JJ cord-253196-et1ekgdl 7 21 interest interest NN cord-253196-et1ekgdl 7 22 as as IN cord-253196-et1ekgdl 7 23 potential potential JJ cord-253196-et1ekgdl 7 24 therapies therapy NNS cord-253196-et1ekgdl 7 25 for for IN cord-253196-et1ekgdl 7 26 coronavirus coronavirus NN cord-253196-et1ekgdl 7 27 disease disease NN cord-253196-et1ekgdl 7 28 2019 2019 CD cord-253196-et1ekgdl 7 29 . . . cord-253196-et1ekgdl 8 1 The the DT cord-253196-et1ekgdl 8 2 authors author NNS cord-253196-et1ekgdl 8 3 of of IN cord-253196-et1ekgdl 8 4 this this DT cord-253196-et1ekgdl 8 5 commentary commentary NN cord-253196-et1ekgdl 8 6 provide provide VBP cord-253196-et1ekgdl 8 7 guidance guidance NN cord-253196-et1ekgdl 8 8 for for IN cord-253196-et1ekgdl 8 9 clinical clinical JJ cord-253196-et1ekgdl 8 10 decision decision NN cord-253196-et1ekgdl 8 11 making make VBG cord-253196-et1ekgdl 8 12 for for IN cord-253196-et1ekgdl 8 13 patients patient NNS cord-253196-et1ekgdl 8 14 with with IN cord-253196-et1ekgdl 8 15 coronavirus coronavirus NN cord-253196-et1ekgdl 8 16 disease disease NN cord-253196-et1ekgdl 8 17 2019 2019 CD cord-253196-et1ekgdl 8 18 as as RB cord-253196-et1ekgdl 8 19 well well RB cord-253196-et1ekgdl 8 20 as as IN cord-253196-et1ekgdl 8 21 for for IN cord-253196-et1ekgdl 8 22 patients patient NNS cord-253196-et1ekgdl 8 23 with with IN cord-253196-et1ekgdl 8 24 rheumatologic rheumatologic JJ cord-253196-et1ekgdl 8 25 conditions condition NNS cord-253196-et1ekgdl 8 26 , , , cord-253196-et1ekgdl 8 27 such such JJ cord-253196-et1ekgdl 8 28 as as IN cord-253196-et1ekgdl 8 29 systemic systemic JJ cord-253196-et1ekgdl 8 30 lupus lupus NN cord-253196-et1ekgdl 8 31 erythematosus erythematosus NN cord-253196-et1ekgdl 8 32 and and CC cord-253196-et1ekgdl 8 33 rheumatoid rheumatoid NN cord-253196-et1ekgdl 8 34 arthritis arthritis NN cord-253196-et1ekgdl 9 1 I -PRON- PRP cord-253196-et1ekgdl 9 2 n n VBP cord-253196-et1ekgdl 9 3 the the DT cord-253196-et1ekgdl 9 4 desperate desperate JJ cord-253196-et1ekgdl 9 5 search search NN cord-253196-et1ekgdl 9 6 to to TO cord-253196-et1ekgdl 9 7 find find VB cord-253196-et1ekgdl 9 8 effective effective JJ cord-253196-et1ekgdl 9 9 treatments treatment NNS cord-253196-et1ekgdl 9 10 for for IN cord-253196-et1ekgdl 9 11 coronavirus coronavirus NN cord-253196-et1ekgdl 9 12 disease disease NN cord-253196-et1ekgdl 9 13 2019 2019 CD cord-253196-et1ekgdl 9 14 ( ( -LRB- cord-253196-et1ekgdl 9 15 COVID-19 COVID-19 NNP cord-253196-et1ekgdl 9 16 ) ) -RRB- cord-253196-et1ekgdl 9 17 , , . cord-253196-et1ekgdl 10 1 2 2 CD cord-253196-et1ekgdl 10 2 generic generic JJ cord-253196-et1ekgdl 10 3 drugs drug NNS cord-253196-et1ekgdl 10 4 , , , cord-253196-et1ekgdl 10 5 used use VBN cord-253196-et1ekgdl 10 6 largely largely RB cord-253196-et1ekgdl 10 7 by by IN cord-253196-et1ekgdl 10 8 rheumatologists rheumatologist NNS cord-253196-et1ekgdl 10 9 and and CC cord-253196-et1ekgdl 10 10 dermatologists dermatologist NNS cord-253196-et1ekgdl 10 11 to to TO cord-253196-et1ekgdl 10 12 treat treat VB cord-253196-et1ekgdl 10 13 immune immune NN cord-253196-et1ekgdl 10 14 - - HYPH cord-253196-et1ekgdl 10 15 mediated mediate VBN cord-253196-et1ekgdl 10 16 diseases disease NNS cord-253196-et1ekgdl 10 17 , , , cord-253196-et1ekgdl 10 18 have have VBP cord-253196-et1ekgdl 10 19 entered enter VBN cord-253196-et1ekgdl 10 20 the the DT cord-253196-et1ekgdl 10 21 spotlight spotlight NN cord-253196-et1ekgdl 10 22 . . . cord-253196-et1ekgdl 11 1 The the DT cord-253196-et1ekgdl 11 2 antimalarials antimalarial NNS cord-253196-et1ekgdl 11 3 hydroxychloroquine hydroxychloroquine NN cord-253196-et1ekgdl 11 4 ( ( -LRB- cord-253196-et1ekgdl 11 5 HCQ HCQ NNP cord-253196-et1ekgdl 11 6 ) ) -RRB- cord-253196-et1ekgdl 11 7 and and CC cord-253196-et1ekgdl 11 8 chloroquine chloroquine NN cord-253196-et1ekgdl 11 9 ( ( -LRB- cord-253196-et1ekgdl 11 10 CQ CQ NNP cord-253196-et1ekgdl 11 11 ) ) -RRB- cord-253196-et1ekgdl 11 12 have have VBP cord-253196-et1ekgdl 11 13 demonstrated demonstrate VBN cord-253196-et1ekgdl 11 14 antiviral antiviral JJ cord-253196-et1ekgdl 11 15 activity activity NN cord-253196-et1ekgdl 11 16 against against IN cord-253196-et1ekgdl 11 17 severe severe JJ cord-253196-et1ekgdl 11 18 acute acute JJ cord-253196-et1ekgdl 11 19 respiratory respiratory JJ cord-253196-et1ekgdl 11 20 syndromecoronavirus syndromecoronavirus NNP cord-253196-et1ekgdl 11 21 2 2 CD cord-253196-et1ekgdl 12 1 ( ( -LRB- cord-253196-et1ekgdl 12 2 SARS SARS NNP cord-253196-et1ekgdl 12 3 - - HYPH cord-253196-et1ekgdl 12 4 CoV-2 CoV-2 NNP cord-253196-et1ekgdl 12 5 ) ) -RRB- cord-253196-et1ekgdl 12 6 in in IN cord-253196-et1ekgdl 12 7 vitro vitro FW cord-253196-et1ekgdl 12 8 and and CC cord-253196-et1ekgdl 12 9 in in IN cord-253196-et1ekgdl 12 10 small small JJ cord-253196-et1ekgdl 12 11 , , , cord-253196-et1ekgdl 12 12 poorly poorly RB cord-253196-et1ekgdl 12 13 controlled control VBN cord-253196-et1ekgdl 12 14 or or CC cord-253196-et1ekgdl 12 15 uncontrolled uncontrolled JJ cord-253196-et1ekgdl 12 16 clinical clinical JJ cord-253196-et1ekgdl 12 17 studies study NNS cord-253196-et1ekgdl 12 18 ( ( -LRB- cord-253196-et1ekgdl 12 19 1 1 CD cord-253196-et1ekgdl 12 20 ) ) -RRB- cord-253196-et1ekgdl 13 1 ( ( -LRB- cord-253196-et1ekgdl 13 2 2 2 LS cord-253196-et1ekgdl 13 3 ) ) -RRB- cord-253196-et1ekgdl 13 4 ( ( -LRB- cord-253196-et1ekgdl 13 5 3 3 CD cord-253196-et1ekgdl 13 6 ) ) -RRB- cord-253196-et1ekgdl 13 7 . . . cord-253196-et1ekgdl 14 1 Normally normally RB cord-253196-et1ekgdl 14 2 , , , cord-253196-et1ekgdl 14 3 such such JJ cord-253196-et1ekgdl 14 4 research research NN cord-253196-et1ekgdl 14 5 would would MD cord-253196-et1ekgdl 14 6 be be VB cord-253196-et1ekgdl 14 7 deemed deem VBN cord-253196-et1ekgdl 14 8 hypothesisgenerating hypothesisgenerating NN cord-253196-et1ekgdl 14 9 at at IN cord-253196-et1ekgdl 14 10 best good JJS cord-253196-et1ekgdl 14 11 . . . cord-253196-et1ekgdl 15 1 A a DT cord-253196-et1ekgdl 15 2 tweet tweet NN cord-253196-et1ekgdl 15 3 by by IN cord-253196-et1ekgdl 15 4 President President NNP cord-253196-et1ekgdl 15 5 Trump Trump NNP cord-253196-et1ekgdl 15 6 on on IN cord-253196-et1ekgdl 15 7 21 21 CD cord-253196-et1ekgdl 15 8 March March NNP cord-253196-et1ekgdl 15 9 2020 2020 CD cord-253196-et1ekgdl 15 10 claiming claim VBG cord-253196-et1ekgdl 15 11 that that IN cord-253196-et1ekgdl 15 12 the the DT cord-253196-et1ekgdl 15 13 combination combination NN cord-253196-et1ekgdl 15 14 of of IN cord-253196-et1ekgdl 15 15 HCQ HCQ NNP cord-253196-et1ekgdl 15 16 and and CC cord-253196-et1ekgdl 15 17 azithromycin azithromycin NNP cord-253196-et1ekgdl 15 18 " " '' cord-253196-et1ekgdl 15 19 ha[s ha[s ADD cord-253196-et1ekgdl 15 20 ] ] -RRB- cord-253196-et1ekgdl 16 1 a a DT cord-253196-et1ekgdl 16 2 real real JJ cord-253196-et1ekgdl 16 3 chance chance NN cord-253196-et1ekgdl 16 4 to to TO cord-253196-et1ekgdl 16 5 be be VB cord-253196-et1ekgdl 16 6 one one CD cord-253196-et1ekgdl 16 7 of of IN cord-253196-et1ekgdl 16 8 the the DT cord-253196-et1ekgdl 16 9 biggest big JJS cord-253196-et1ekgdl 16 10 game game NN cord-253196-et1ekgdl 16 11 changers changer NNS cord-253196-et1ekgdl 16 12 in in IN cord-253196-et1ekgdl 16 13 the the DT cord-253196-et1ekgdl 16 14 history history NN cord-253196-et1ekgdl 16 15 of of IN cord-253196-et1ekgdl 16 16 medicine medicine NN cord-253196-et1ekgdl 16 17 " " '' cord-253196-et1ekgdl 16 18 accelerated accelerate VBD cord-253196-et1ekgdl 16 19 a a DT cord-253196-et1ekgdl 16 20 worldwide worldwide JJ cord-253196-et1ekgdl 16 21 run run NN cord-253196-et1ekgdl 16 22 on on IN cord-253196-et1ekgdl 16 23 the the DT cord-253196-et1ekgdl 16 24 drugs drug NNS cord-253196-et1ekgdl 16 25 , , , cord-253196-et1ekgdl 16 26 with with IN cord-253196-et1ekgdl 16 27 pharmacies pharmacy NNS cord-253196-et1ekgdl 16 28 reporting report VBG cord-253196-et1ekgdl 16 29 shortages shortage NNS cord-253196-et1ekgdl 16 30 within within IN cord-253196-et1ekgdl 16 31 24 24 CD cord-253196-et1ekgdl 16 32 hours hour NNS cord-253196-et1ekgdl 16 33 . . . cord-253196-et1ekgdl 17 1 Here here RB cord-253196-et1ekgdl 17 2 , , , cord-253196-et1ekgdl 17 3 we -PRON- PRP cord-253196-et1ekgdl 17 4 try try VBP cord-253196-et1ekgdl 17 5 to to TO cord-253196-et1ekgdl 17 6 provide provide VB cord-253196-et1ekgdl 17 7 guidance guidance NN cord-253196-et1ekgdl 17 8 regarding regard VBG cord-253196-et1ekgdl 17 9 clinical clinical JJ cord-253196-et1ekgdl 17 10 decision decision NN cord-253196-et1ekgdl 17 11 making make VBG cord-253196-et1ekgdl 17 12 both both DT cord-253196-et1ekgdl 17 13 for for IN cord-253196-et1ekgdl 17 14 patients patient NNS cord-253196-et1ekgdl 17 15 with with IN cord-253196-et1ekgdl 17 16 COVID-19 COVID-19 NNP cord-253196-et1ekgdl 17 17 and and CC cord-253196-et1ekgdl 17 18 those those DT cord-253196-et1ekgdl 17 19 with with IN cord-253196-et1ekgdl 17 20 immune immune NN cord-253196-et1ekgdl 17 21 - - HYPH cord-253196-et1ekgdl 17 22 mediated mediate VBN cord-253196-et1ekgdl 17 23 conditions condition NNS cord-253196-et1ekgdl 17 24 , , , cord-253196-et1ekgdl 17 25 such such JJ cord-253196-et1ekgdl 17 26 as as IN cord-253196-et1ekgdl 17 27 systemic systemic JJ cord-253196-et1ekgdl 17 28 lupus lupus NN cord-253196-et1ekgdl 17 29 erythematosus erythematosus NN cord-253196-et1ekgdl 17 30 ( ( -LRB- cord-253196-et1ekgdl 17 31 SLE SLE NNP cord-253196-et1ekgdl 17 32 ) ) -RRB- cord-253196-et1ekgdl 17 33 and and CC cord-253196-et1ekgdl 17 34 rheumatoid rheumatoid NN cord-253196-et1ekgdl 17 35 arthritis arthritis NN cord-253196-et1ekgdl 17 36 ( ( -LRB- cord-253196-et1ekgdl 17 37 RA RA NNP cord-253196-et1ekgdl 17 38 ) ) -RRB- cord-253196-et1ekgdl 17 39 , , , cord-253196-et1ekgdl 17 40 and and CC cord-253196-et1ekgdl 17 41 strategies strategy NNS cord-253196-et1ekgdl 17 42 to to TO cord-253196-et1ekgdl 17 43 mitigate mitigate VB cord-253196-et1ekgdl 17 44 further further JJ cord-253196-et1ekgdl 17 45 harm harm NN cord-253196-et1ekgdl 17 46 to to IN cord-253196-et1ekgdl 17 47 these these DT cord-253196-et1ekgdl 17 48 patients patient NNS cord-253196-et1ekgdl 17 49 . . . cord-253196-et1ekgdl 18 1 Data datum NNS cord-253196-et1ekgdl 18 2 to to TO cord-253196-et1ekgdl 18 3 support support VB cord-253196-et1ekgdl 18 4 the the DT cord-253196-et1ekgdl 18 5 use use NN cord-253196-et1ekgdl 18 6 of of IN cord-253196-et1ekgdl 18 7 HCQ HCQ NNP cord-253196-et1ekgdl 18 8 and and CC cord-253196-et1ekgdl 18 9 CQ CQ NNP cord-253196-et1ekgdl 18 10 for for IN cord-253196-et1ekgdl 18 11 COVID-19 COVID-19 NNP cord-253196-et1ekgdl 18 12 are be VBP cord-253196-et1ekgdl 18 13 limited limited JJ cord-253196-et1ekgdl 18 14 and and CC cord-253196-et1ekgdl 18 15 inconclusive inconclusive JJ cord-253196-et1ekgdl 18 16 . . . cord-253196-et1ekgdl 19 1 The the DT cord-253196-et1ekgdl 19 2 drugs drug NNS cord-253196-et1ekgdl 19 3 have have VBP cord-253196-et1ekgdl 19 4 some some DT cord-253196-et1ekgdl 19 5 in in IN cord-253196-et1ekgdl 19 6 vitro vitro FW cord-253196-et1ekgdl 19 7 activity activity NN cord-253196-et1ekgdl 19 8 against against IN cord-253196-et1ekgdl 19 9 several several JJ cord-253196-et1ekgdl 19 10 viruses virus NNS cord-253196-et1ekgdl 19 11 , , , cord-253196-et1ekgdl 19 12 including include VBG cord-253196-et1ekgdl 19 13 coronaviruses coronaviruse NNS cord-253196-et1ekgdl 19 14 and and CC cord-253196-et1ekgdl 19 15 influenza influenza NN cord-253196-et1ekgdl 19 16 , , , cord-253196-et1ekgdl 19 17 but but CC cord-253196-et1ekgdl 19 18 previous previous JJ cord-253196-et1ekgdl 19 19 randomized randomized JJ cord-253196-et1ekgdl 19 20 trials trial NNS cord-253196-et1ekgdl 19 21 in in IN cord-253196-et1ekgdl 19 22 patients patient NNS cord-253196-et1ekgdl 19 23 with with IN cord-253196-et1ekgdl 19 24 influenza influenza NN cord-253196-et1ekgdl 19 25 have have VBP cord-253196-et1ekgdl 19 26 been be VBN cord-253196-et1ekgdl 19 27 negative negative JJ cord-253196-et1ekgdl 19 28 ( ( -LRB- cord-253196-et1ekgdl 19 29 4 4 CD cord-253196-et1ekgdl 19 30 , , , cord-253196-et1ekgdl 19 31 5 5 CD cord-253196-et1ekgdl 19 32 ) ) -RRB- cord-253196-et1ekgdl 19 33 . . . cord-253196-et1ekgdl 20 1 In in IN cord-253196-et1ekgdl 20 2 COVID-19 COVID-19 NNP cord-253196-et1ekgdl 20 3 , , , cord-253196-et1ekgdl 20 4 one one CD cord-253196-et1ekgdl 20 5 small small JJ cord-253196-et1ekgdl 20 6 nonrandomized nonrandomize VBN cord-253196-et1ekgdl 20 7 study study NN cord-253196-et1ekgdl 20 8 from from IN cord-253196-et1ekgdl 20 9 France France NNP cord-253196-et1ekgdl 20 10 ( ( -LRB- cord-253196-et1ekgdl 20 11 3 3 CD cord-253196-et1ekgdl 20 12 ) ) -RRB- cord-253196-et1ekgdl 20 13 ( ( -LRB- cord-253196-et1ekgdl 20 14 discussed discuss VBN cord-253196-et1ekgdl 20 15 elsewhere elsewhere RB cord-253196-et1ekgdl 20 16 in in IN cord-253196-et1ekgdl 20 17 Annals Annals NNP cord-253196-et1ekgdl 20 18 of of IN cord-253196-et1ekgdl 20 19 Internal Internal NNP cord-253196-et1ekgdl 20 20 Medicine Medicine NNP cord-253196-et1ekgdl 20 21 [ [ -LRB- cord-253196-et1ekgdl 20 22 6 6 CD cord-253196-et1ekgdl 20 23 ] ] -RRB- cord-253196-et1ekgdl 20 24 ) ) -RRB- cord-253196-et1ekgdl 20 25 demonstrated demonstrate VBD cord-253196-et1ekgdl 20 26 benefit benefit NN cord-253196-et1ekgdl 20 27 but but CC cord-253196-et1ekgdl 20 28 had have VBD cord-253196-et1ekgdl 20 29 serious serious JJ cord-253196-et1ekgdl 20 30 methodological methodological JJ cord-253196-et1ekgdl 20 31 flaws flaw NNS cord-253196-et1ekgdl 20 32 , , , cord-253196-et1ekgdl 20 33 and and CC cord-253196-et1ekgdl 20 34 a a DT cord-253196-et1ekgdl 20 35 follow follow VB cord-253196-et1ekgdl 20 36 - - HYPH cord-253196-et1ekgdl 20 37 up up NN cord-253196-et1ekgdl 20 38 study study NN cord-253196-et1ekgdl 20 39 still still RB cord-253196-et1ekgdl 20 40 lacked lack VBD cord-253196-et1ekgdl 20 41 a a DT cord-253196-et1ekgdl 20 42 control control NN cord-253196-et1ekgdl 20 43 group group NN cord-253196-et1ekgdl 20 44 . . . cord-253196-et1ekgdl 21 1 Yet yet RB cord-253196-et1ekgdl 21 2 , , , cord-253196-et1ekgdl 21 3 another another DT cord-253196-et1ekgdl 21 4 very very RB cord-253196-et1ekgdl 21 5 small small JJ cord-253196-et1ekgdl 21 6 , , , cord-253196-et1ekgdl 21 7 randomized randomized JJ cord-253196-et1ekgdl 21 8 study study NN cord-253196-et1ekgdl 21 9 from from IN cord-253196-et1ekgdl 21 10 China China NNP cord-253196-et1ekgdl 21 11 in in IN cord-253196-et1ekgdl 21 12 patients patient NNS cord-253196-et1ekgdl 21 13 with with IN cord-253196-et1ekgdl 21 14 mild mild JJ cord-253196-et1ekgdl 21 15 to to TO cord-253196-et1ekgdl 21 16 moderate moderate JJ cord-253196-et1ekgdl 21 17 COVID-19 COVID-19 NNP cord-253196-et1ekgdl 21 18 found find VBD cord-253196-et1ekgdl 21 19 no no DT cord-253196-et1ekgdl 21 20 difference difference NN cord-253196-et1ekgdl 21 21 in in IN cord-253196-et1ekgdl 21 22 recovery recovery NN cord-253196-et1ekgdl 21 23 rates rate NNS cord-253196-et1ekgdl 21 24 ( ( -LRB- cord-253196-et1ekgdl 21 25 7 7 CD cord-253196-et1ekgdl 21 26 ) ) -RRB- cord-253196-et1ekgdl 21 27 . . . cord-253196-et1ekgdl 22 1 Sadly sadly RB cord-253196-et1ekgdl 22 2 , , , cord-253196-et1ekgdl 22 3 reports report NNS cord-253196-et1ekgdl 22 4 of of IN cord-253196-et1ekgdl 22 5 adverse adverse JJ cord-253196-et1ekgdl 22 6 events event NNS cord-253196-et1ekgdl 22 7 have have VBP cord-253196-et1ekgdl 22 8 increased increase VBN cord-253196-et1ekgdl 22 9 , , , cord-253196-et1ekgdl 22 10 with with IN cord-253196-et1ekgdl 22 11 several several JJ cord-253196-et1ekgdl 22 12 countries country NNS cord-253196-et1ekgdl 22 13 reporting report VBG cord-253196-et1ekgdl 22 14 poisonings poisoning NNS cord-253196-et1ekgdl 22 15 and and CC cord-253196-et1ekgdl 22 16 at at IN cord-253196-et1ekgdl 22 17 least least JJS cord-253196-et1ekgdl 22 18 1 1 CD cord-253196-et1ekgdl 22 19 death death NN cord-253196-et1ekgdl 22 20 reported report VBN cord-253196-et1ekgdl 22 21 in in IN cord-253196-et1ekgdl 22 22 a a DT cord-253196-et1ekgdl 22 23 patient patient NN cord-253196-et1ekgdl 22 24 who who WP cord-253196-et1ekgdl 22 25 drank drank VBP cord-253196-et1ekgdl 22 26 fish fish NN cord-253196-et1ekgdl 22 27 tank tank NN cord-253196-et1ekgdl 22 28 cleaner cleaner NN cord-253196-et1ekgdl 22 29 because because IN cord-253196-et1ekgdl 22 30 of of IN cord-253196-et1ekgdl 22 31 its -PRON- PRP$ cord-253196-et1ekgdl 22 32 CQ CQ NNP cord-253196-et1ekgdl 22 33 content content NN cord-253196-et1ekgdl 22 34 . . . cord-253196-et1ekgdl 23 1 Antimalarial antimalarial JJ cord-253196-et1ekgdl 23 2 drugs drug NNS cord-253196-et1ekgdl 23 3 can can MD cord-253196-et1ekgdl 23 4 cause cause VB cord-253196-et1ekgdl 23 5 ventricular ventricular JJ cord-253196-et1ekgdl 23 6 arrhythmias arrhythmias RB cord-253196-et1ekgdl 23 7 , , , cord-253196-et1ekgdl 23 8 QT qt NN cord-253196-et1ekgdl 23 9 prolongation prolongation NN cord-253196-et1ekgdl 23 10 , , , cord-253196-et1ekgdl 23 11 and and CC cord-253196-et1ekgdl 23 12 other other JJ cord-253196-et1ekgdl 23 13 cardiac cardiac JJ cord-253196-et1ekgdl 23 14 toxicity toxicity NN cord-253196-et1ekgdl 23 15 , , , cord-253196-et1ekgdl 23 16 which which WDT cord-253196-et1ekgdl 23 17 may may MD cord-253196-et1ekgdl 23 18 pose pose VB cord-253196-et1ekgdl 23 19 particular particular JJ cord-253196-et1ekgdl 23 20 risk risk NN cord-253196-et1ekgdl 23 21 to to TO cord-253196-et1ekgdl 23 22 critically critically RB cord-253196-et1ekgdl 23 23 ill ill JJ cord-253196-et1ekgdl 23 24 persons person NNS cord-253196-et1ekgdl 23 25 . . . cord-253196-et1ekgdl 24 1 Given give VBN cord-253196-et1ekgdl 24 2 these these DT cord-253196-et1ekgdl 24 3 serious serious JJ cord-253196-et1ekgdl 24 4 potential potential JJ cord-253196-et1ekgdl 24 5 adverse adverse JJ cord-253196-et1ekgdl 24 6 effects effect NNS cord-253196-et1ekgdl 24 7 , , , cord-253196-et1ekgdl 24 8 the the DT cord-253196-et1ekgdl 24 9 hasty hasty JJ cord-253196-et1ekgdl 24 10 and and CC cord-253196-et1ekgdl 24 11 inappropriate inappropriate JJ cord-253196-et1ekgdl 24 12 interpretation interpretation NN cord-253196-et1ekgdl 24 13 of of IN cord-253196-et1ekgdl 24 14 the the DT cord-253196-et1ekgdl 24 15 literature literature NN cord-253196-et1ekgdl 24 16 by by IN cord-253196-et1ekgdl 24 17 public public JJ cord-253196-et1ekgdl 24 18 leaders leader NNS cord-253196-et1ekgdl 24 19 has have VBZ cord-253196-et1ekgdl 24 20 potential potential NN cord-253196-et1ekgdl 24 21 to to TO cord-253196-et1ekgdl 24 22 do do VB cord-253196-et1ekgdl 24 23 serious serious JJ cord-253196-et1ekgdl 24 24 harm harm NN cord-253196-et1ekgdl 24 25 . . . cord-253196-et1ekgdl 25 1 At at IN cord-253196-et1ekgdl 25 2 this this DT cord-253196-et1ekgdl 25 3 time time NN cord-253196-et1ekgdl 25 4 of of IN cord-253196-et1ekgdl 25 5 crisis crisis NN cord-253196-et1ekgdl 25 6 , , , cord-253196-et1ekgdl 25 7 it -PRON- PRP cord-253196-et1ekgdl 25 8 is be VBZ cord-253196-et1ekgdl 25 9 our -PRON- PRP$ cord-253196-et1ekgdl 25 10 ethical ethical JJ cord-253196-et1ekgdl 25 11 obligation obligation NN cord-253196-et1ekgdl 25 12 as as IN cord-253196-et1ekgdl 25 13 physicians physician NNS cord-253196-et1ekgdl 25 14 and and CC cord-253196-et1ekgdl 25 15 researchers researcher NNS cord-253196-et1ekgdl 25 16 to to TO cord-253196-et1ekgdl 25 17 organize organize VB cord-253196-et1ekgdl 25 18 and and CC cord-253196-et1ekgdl 25 19 refer refer VB cord-253196-et1ekgdl 25 20 patients patient NNS cord-253196-et1ekgdl 25 21 to to IN cord-253196-et1ekgdl 25 22 expedited expedite VBN cord-253196-et1ekgdl 25 23 , , , cord-253196-et1ekgdl 25 24 well well RB cord-253196-et1ekgdl 25 25 - - HYPH cord-253196-et1ekgdl 25 26 performed perform VBN cord-253196-et1ekgdl 25 27 randomized randomized JJ cord-253196-et1ekgdl 25 28 trials trial NNS cord-253196-et1ekgdl 25 29 that that WDT cord-253196-et1ekgdl 25 30 can can MD cord-253196-et1ekgdl 25 31 clarify clarify VB cord-253196-et1ekgdl 25 32 if if IN cord-253196-et1ekgdl 25 33 , , , cord-253196-et1ekgdl 25 34 when when WRB cord-253196-et1ekgdl 25 35 , , , cord-253196-et1ekgdl 25 36 and and CC cord-253196-et1ekgdl 25 37 for for IN cord-253196-et1ekgdl 25 38 whom whom WP cord-253196-et1ekgdl 25 39 antimalarial antimalarial JJ cord-253196-et1ekgdl 25 40 medications medication NNS cord-253196-et1ekgdl 25 41 are be VBP cord-253196-et1ekgdl 25 42 helpful helpful JJ cord-253196-et1ekgdl 25 43 in in IN cord-253196-et1ekgdl 25 44 COVID-19 COVID-19 NNP cord-253196-et1ekgdl 25 45 . . . cord-253196-et1ekgdl 26 1 As as IN cord-253196-et1ekgdl 26 2 of of IN cord-253196-et1ekgdl 26 3 this this DT cord-253196-et1ekgdl 26 4 writing writing NN cord-253196-et1ekgdl 26 5 , , , cord-253196-et1ekgdl 26 6 10 10 CD cord-253196-et1ekgdl 26 7 such such JJ cord-253196-et1ekgdl 26 8 trials trial NNS cord-253196-et1ekgdl 26 9 are be VBP cord-253196-et1ekgdl 26 10 under under IN cord-253196-et1ekgdl 26 11 way way NN cord-253196-et1ekgdl 26 12 , , , cord-253196-et1ekgdl 26 13 and and CC cord-253196-et1ekgdl 26 14 information information NN cord-253196-et1ekgdl 26 15 should should MD cord-253196-et1ekgdl 26 16 be be VB cord-253196-et1ekgdl 26 17 forthcoming forthcoming JJ cord-253196-et1ekgdl 26 18 within within IN cord-253196-et1ekgdl 26 19 weeks week NNS cord-253196-et1ekgdl 26 20 . . . cord-253196-et1ekgdl 27 1 Whereas whereas IN cord-253196-et1ekgdl 27 2 the the DT cord-253196-et1ekgdl 27 3 evidence evidence NN cord-253196-et1ekgdl 27 4 supporting support VBG cord-253196-et1ekgdl 27 5 the the DT cord-253196-et1ekgdl 27 6 use use NN cord-253196-et1ekgdl 27 7 of of IN cord-253196-et1ekgdl 27 8 antimalarial antimalarial JJ cord-253196-et1ekgdl 27 9 medications medication NNS cord-253196-et1ekgdl 27 10 for for IN cord-253196-et1ekgdl 27 11 COVID-19 COVID-19 NNP cord-253196-et1ekgdl 27 12 is be VBZ cord-253196-et1ekgdl 27 13 equivocal equivocal JJ cord-253196-et1ekgdl 27 14 , , , cord-253196-et1ekgdl 27 15 the the DT cord-253196-et1ekgdl 27 16 evidence evidence NN cord-253196-et1ekgdl 27 17 for for IN cord-253196-et1ekgdl 27 18 the the DT cord-253196-et1ekgdl 27 19 use use NN cord-253196-et1ekgdl 27 20 of of IN cord-253196-et1ekgdl 27 21 these these DT cord-253196-et1ekgdl 27 22 drugs drug NNS cord-253196-et1ekgdl 27 23 to to TO cord-253196-et1ekgdl 27 24 treat treat VB cord-253196-et1ekgdl 27 25 immune immune NN cord-253196-et1ekgdl 27 26 - - HYPH cord-253196-et1ekgdl 27 27 mediated mediate VBN cord-253196-et1ekgdl 27 28 diseases disease NNS cord-253196-et1ekgdl 27 29 is be VBZ cord-253196-et1ekgdl 27 30 not not RB cord-253196-et1ekgdl 27 31 . . . cord-253196-et1ekgdl 28 1 For for IN cord-253196-et1ekgdl 28 2 example example NN cord-253196-et1ekgdl 28 3 , , , cord-253196-et1ekgdl 28 4 HCQ HCQ NNP cord-253196-et1ekgdl 28 5 is be VBZ cord-253196-et1ekgdl 28 6 a a DT cord-253196-et1ekgdl 28 7 cornerstone cornerstone NN cord-253196-et1ekgdl 28 8 of of IN cord-253196-et1ekgdl 28 9 therapy therapy NN cord-253196-et1ekgdl 28 10 for for IN cord-253196-et1ekgdl 28 11 SLE SLE NNP cord-253196-et1ekgdl 28 12 . . . cord-253196-et1ekgdl 29 1 Hydroxychloroquine Hydroxychloroquine NNP cord-253196-et1ekgdl 29 2 can can MD cord-253196-et1ekgdl 29 3 effectively effectively RB cord-253196-et1ekgdl 29 4 treat treat VB cord-253196-et1ekgdl 29 5 disease disease NN cord-253196-et1ekgdl 29 6 manifestations manifestation NNS cord-253196-et1ekgdl 29 7 , , , cord-253196-et1ekgdl 29 8 such such JJ cord-253196-et1ekgdl 29 9 as as IN cord-253196-et1ekgdl 29 10 joint joint JJ cord-253196-et1ekgdl 29 11 pain pain NN cord-253196-et1ekgdl 29 12 and and CC cord-253196-et1ekgdl 29 13 rashes rash NNS cord-253196-et1ekgdl 29 14 ; ; : cord-253196-et1ekgdl 29 15 reduce reduce VB cord-253196-et1ekgdl 29 16 thrombotic thrombotic JJ cord-253196-et1ekgdl 29 17 events event NNS cord-253196-et1ekgdl 29 18 ; ; : cord-253196-et1ekgdl 29 19 and and CC cord-253196-et1ekgdl 29 20 prolong prolong VB cord-253196-et1ekgdl 29 21 survival survival NN cord-253196-et1ekgdl 29 22 . . . cord-253196-et1ekgdl 30 1 Of of IN cord-253196-et1ekgdl 30 2 note note VB cord-253196-et1ekgdl 30 3 , , , cord-253196-et1ekgdl 30 4 landmark landmark VB cord-253196-et1ekgdl 30 5 clinical clinical JJ cord-253196-et1ekgdl 30 6 trials trial NNS cord-253196-et1ekgdl 30 7 have have VBP cord-253196-et1ekgdl 30 8 demonstrated demonstrate VBN cord-253196-et1ekgdl 30 9 that that IN cord-253196-et1ekgdl 30 10 the the DT cord-253196-et1ekgdl 30 11 withdrawal withdrawal NN cord-253196-et1ekgdl 30 12 of of IN cord-253196-et1ekgdl 30 13 HCQ HCQ NNP cord-253196-et1ekgdl 30 14 can can MD cord-253196-et1ekgdl 30 15 lead lead VB cord-253196-et1ekgdl 30 16 to to IN cord-253196-et1ekgdl 30 17 flares flare NNS cord-253196-et1ekgdl 30 18 of of IN cord-253196-et1ekgdl 30 19 disease disease NN cord-253196-et1ekgdl 30 20 , , , cord-253196-et1ekgdl 30 21 including include VBG cord-253196-et1ekgdl 30 22 life life NN cord-253196-et1ekgdl 30 23 - - HYPH cord-253196-et1ekgdl 30 24 threatening threaten VBG cord-253196-et1ekgdl 30 25 manifestations manifestation NNS cord-253196-et1ekgdl 30 26 , , , cord-253196-et1ekgdl 30 27 such such JJ cord-253196-et1ekgdl 30 28 as as IN cord-253196-et1ekgdl 30 29 lupus lupus NN cord-253196-et1ekgdl 30 30 nephritis nephritis NN cord-253196-et1ekgdl 30 31 ( ( -LRB- cord-253196-et1ekgdl 30 32 8) 8) NNP cord-253196-et1ekgdl 30 33 . . . cord-253196-et1ekgdl 31 1 The the DT cord-253196-et1ekgdl 31 2 current current JJ cord-253196-et1ekgdl 31 3 shortages shortage NNS cord-253196-et1ekgdl 31 4 of of IN cord-253196-et1ekgdl 31 5 HCQ HCQ NNP cord-253196-et1ekgdl 31 6 have have VBP cord-253196-et1ekgdl 31 7 therefore therefore RB cord-253196-et1ekgdl 31 8 alarmed alarm VBN cord-253196-et1ekgdl 31 9 rheumatologists rheumatologist NNS cord-253196-et1ekgdl 31 10 and and CC cord-253196-et1ekgdl 31 11 patients patient NNS cord-253196-et1ekgdl 31 12 . . . cord-253196-et1ekgdl 32 1 Offices office NNS cord-253196-et1ekgdl 32 2 across across IN cord-253196-et1ekgdl 32 3 the the DT cord-253196-et1ekgdl 32 4 country country NN cord-253196-et1ekgdl 32 5 report report VBP cord-253196-et1ekgdl 32 6 fielding fielding NN cord-253196-et1ekgdl 32 7 calls call NNS cord-253196-et1ekgdl 32 8 from from IN cord-253196-et1ekgdl 32 9 concerned concerned JJ cord-253196-et1ekgdl 32 10 patients patient NNS cord-253196-et1ekgdl 32 11 who who WP cord-253196-et1ekgdl 32 12 are be VBP cord-253196-et1ekgdl 32 13 having have VBG cord-253196-et1ekgdl 32 14 difficulty difficulty NN cord-253196-et1ekgdl 32 15 obtaining obtain VBG cord-253196-et1ekgdl 32 16 their -PRON- PRP$ cord-253196-et1ekgdl 32 17 medication medication NN cord-253196-et1ekgdl 32 18 . . . cord-253196-et1ekgdl 33 1 Given give VBN cord-253196-et1ekgdl 33 2 the the DT cord-253196-et1ekgdl 33 3 likelihood likelihood NN cord-253196-et1ekgdl 33 4 that that IN cord-253196-et1ekgdl 33 5 shortages shortage NNS cord-253196-et1ekgdl 33 6 will will MD cord-253196-et1ekgdl 33 7 continue continue VB cord-253196-et1ekgdl 33 8 in in IN cord-253196-et1ekgdl 33 9 the the DT cord-253196-et1ekgdl 33 10 near near JJ cord-253196-et1ekgdl 33 11 term term NN cord-253196-et1ekgdl 33 12 , , , cord-253196-et1ekgdl 33 13 we -PRON- PRP cord-253196-et1ekgdl 33 14 propose propose VBP cord-253196-et1ekgdl 33 15 that that IN cord-253196-et1ekgdl 33 16 manufacturers manufacturer NNS cord-253196-et1ekgdl 33 17 , , , cord-253196-et1ekgdl 33 18 clinicians clinician NNS cord-253196-et1ekgdl 33 19 , , , cord-253196-et1ekgdl 33 20 pharmacies pharmacy NNS cord-253196-et1ekgdl 33 21 , , , cord-253196-et1ekgdl 33 22 health health NN cord-253196-et1ekgdl 33 23 systems system NNS cord-253196-et1ekgdl 33 24 , , , cord-253196-et1ekgdl 33 25 and and CC cord-253196-et1ekgdl 33 26 governmental governmental JJ cord-253196-et1ekgdl 33 27 health health NN cord-253196-et1ekgdl 33 28 agencies agency NNS cord-253196-et1ekgdl 33 29 continue continue VBP cord-253196-et1ekgdl 33 30 to to TO cord-253196-et1ekgdl 33 31 coordinate coordinate VB cord-253196-et1ekgdl 33 32 an an DT cord-253196-et1ekgdl 33 33 aggressive aggressive JJ cord-253196-et1ekgdl 33 34 response response NN cord-253196-et1ekgdl 33 35 to to TO cord-253196-et1ekgdl 33 36 ensure ensure VB cord-253196-et1ekgdl 33 37 that that IN cord-253196-et1ekgdl 33 38 antimalarial antimalarial JJ cord-253196-et1ekgdl 33 39 drug drug NN cord-253196-et1ekgdl 33 40 use use NN cord-253196-et1ekgdl 33 41 is be VBZ cord-253196-et1ekgdl 33 42 appropriately appropriately RB cord-253196-et1ekgdl 33 43 managed manage VBN cord-253196-et1ekgdl 33 44 during during IN cord-253196-et1ekgdl 33 45 the the DT cord-253196-et1ekgdl 33 46 COVID-19 COVID-19 NNP cord-253196-et1ekgdl 33 47 pandemic pandemic NN cord-253196-et1ekgdl 33 48 . . . cord-253196-et1ekgdl 34 1 First first RB cord-253196-et1ekgdl 34 2 , , , cord-253196-et1ekgdl 34 3 it -PRON- PRP cord-253196-et1ekgdl 34 4 is be VBZ cord-253196-et1ekgdl 34 5 important important JJ cord-253196-et1ekgdl 34 6 to to TO cord-253196-et1ekgdl 34 7 prioritize prioritize VB cord-253196-et1ekgdl 34 8 available available JJ cord-253196-et1ekgdl 34 9 supply supply NN cord-253196-et1ekgdl 34 10 for for IN cord-253196-et1ekgdl 34 11 clinical clinical JJ cord-253196-et1ekgdl 34 12 trials trial NNS cord-253196-et1ekgdl 34 13 evaluating evaluate VBG cord-253196-et1ekgdl 34 14 important important JJ cord-253196-et1ekgdl 34 15 questions question NNS cord-253196-et1ekgdl 34 16 , , , cord-253196-et1ekgdl 34 17 such such JJ cord-253196-et1ekgdl 34 18 as as IN cord-253196-et1ekgdl 34 19 dosing dosing NN cord-253196-et1ekgdl 34 20 , , , cord-253196-et1ekgdl 34 21 prophylaxis prophylaxis NN cord-253196-et1ekgdl 34 22 , , , cord-253196-et1ekgdl 34 23 and and CC cord-253196-et1ekgdl 34 24 treatment treatment NN cord-253196-et1ekgdl 34 25 in in IN cord-253196-et1ekgdl 34 26 COVID-19 COVID-19 NNP cord-253196-et1ekgdl 34 27 . . . cord-253196-et1ekgdl 35 1 Second second JJ cord-253196-et1ekgdl 35 2 , , , cord-253196-et1ekgdl 35 3 treatment treatment NN cord-253196-et1ekgdl 35 4 interruptions interruption NNS cord-253196-et1ekgdl 35 5 for for IN cord-253196-et1ekgdl 35 6 those those DT cord-253196-et1ekgdl 35 7 with with IN cord-253196-et1ekgdl 35 8 SLE SLE NNP cord-253196-et1ekgdl 35 9 and and CC cord-253196-et1ekgdl 35 10 other other JJ cord-253196-et1ekgdl 35 11 rheumatic rheumatic JJ cord-253196-et1ekgdl 35 12 diseases disease NNS cord-253196-et1ekgdl 35 13 must must MD cord-253196-et1ekgdl 35 14 be be VB cord-253196-et1ekgdl 35 15 prevented prevent VBN cord-253196-et1ekgdl 35 16 , , , cord-253196-et1ekgdl 35 17 because because IN cord-253196-et1ekgdl 35 18 lapses lapse NNS cord-253196-et1ekgdl 35 19 in in IN cord-253196-et1ekgdl 35 20 therapy therapy NN cord-253196-et1ekgdl 35 21 can can MD cord-253196-et1ekgdl 35 22 result result VB cord-253196-et1ekgdl 35 23 in in IN cord-253196-et1ekgdl 35 24 disease disease NN cord-253196-et1ekgdl 35 25 flares flare NNS cord-253196-et1ekgdl 35 26 and and CC cord-253196-et1ekgdl 35 27 strain strain VBP cord-253196-et1ekgdl 35 28 already already RB cord-253196-et1ekgdl 35 29 stretched stretch VBN cord-253196-et1ekgdl 35 30 health health NN cord-253196-et1ekgdl 35 31 care care NN cord-253196-et1ekgdl 35 32 resources resource NNS cord-253196-et1ekgdl 35 33 . . . cord-253196-et1ekgdl 36 1 Third third JJ cord-253196-et1ekgdl 36 2 , , , cord-253196-et1ekgdl 36 3 stakeholders stakeholder NNS cord-253196-et1ekgdl 36 4 should should MD cord-253196-et1ekgdl 36 5 work work VB cord-253196-et1ekgdl 36 6 together together RB cord-253196-et1ekgdl 36 7 to to TO cord-253196-et1ekgdl 36 8 see see VB cord-253196-et1ekgdl 36 9 whether whether IN cord-253196-et1ekgdl 36 10 dispensation dispensation NN cord-253196-et1ekgdl 36 11 of of IN cord-253196-et1ekgdl 36 12 remaining remain VBG cord-253196-et1ekgdl 36 13 supply supply NN cord-253196-et1ekgdl 36 14 to to IN cord-253196-et1ekgdl 36 15 patients patient NNS cord-253196-et1ekgdl 36 16 with with IN cord-253196-et1ekgdl 36 17 COVID-19 covid-19 JJ cord-253196-et1ekgdl 36 18 makes make VBZ cord-253196-et1ekgdl 36 19 sense sense NN cord-253196-et1ekgdl 36 20 as as IN cord-253196-et1ekgdl 36 21 evidence evidence NN cord-253196-et1ekgdl 36 22 rapidly rapidly RB cord-253196-et1ekgdl 36 23 changes change VBZ cord-253196-et1ekgdl 36 24 . . . cord-253196-et1ekgdl 37 1 Fourth fourth JJ cord-253196-et1ekgdl 37 2 , , , cord-253196-et1ekgdl 37 3 clear clear JJ cord-253196-et1ekgdl 37 4 messages message NNS cord-253196-et1ekgdl 37 5 that that WDT cord-253196-et1ekgdl 37 6 reflect reflect VBP cord-253196-et1ekgdl 37 7 the the DT cord-253196-et1ekgdl 37 8 proper proper JJ cord-253196-et1ekgdl 37 9 interpretations interpretation NNS cord-253196-et1ekgdl 37 10 of of IN cord-253196-et1ekgdl 37 11 available available JJ cord-253196-et1ekgdl 37 12 data datum NNS cord-253196-et1ekgdl 37 13 must must MD cord-253196-et1ekgdl 37 14 be be VB cord-253196-et1ekgdl 37 15 disseminated disseminate VBN cord-253196-et1ekgdl 37 16 with with IN cord-253196-et1ekgdl 37 17 high high JJ cord-253196-et1ekgdl 37 18 frequency frequency NN cord-253196-et1ekgdl 37 19 to to TO cord-253196-et1ekgdl 37 20 counteract counteract VB cord-253196-et1ekgdl 37 21 misinformation misinformation NN cord-253196-et1ekgdl 37 22 , , , cord-253196-et1ekgdl 37 23 including include VBG cord-253196-et1ekgdl 37 24 misleading misleading JJ cord-253196-et1ekgdl 37 25 statements statement NNS cord-253196-et1ekgdl 37 26 or or CC cord-253196-et1ekgdl 37 27 articles article NNS cord-253196-et1ekgdl 37 28 with with IN cord-253196-et1ekgdl 37 29 " " `` cord-253196-et1ekgdl 37 30 clickbait clickbait JJ cord-253196-et1ekgdl 37 31 " " '' cord-253196-et1ekgdl 37 32 material material NN cord-253196-et1ekgdl 37 33 . . . cord-253196-et1ekgdl 38 1 Finally finally RB cord-253196-et1ekgdl 38 2 , , , cord-253196-et1ekgdl 38 3 safeguards safeguard NNS cord-253196-et1ekgdl 38 4 should should MD cord-253196-et1ekgdl 38 5 be be VB cord-253196-et1ekgdl 38 6 put put VBN cord-253196-et1ekgdl 38 7 into into IN cord-253196-et1ekgdl 38 8 place place NN cord-253196-et1ekgdl 38 9 to to TO cord-253196-et1ekgdl 38 10 discourage discourage VB cord-253196-et1ekgdl 38 11 overutilization overutilization NN cord-253196-et1ekgdl 38 12 by by IN cord-253196-et1ekgdl 38 13 health health NN cord-253196-et1ekgdl 38 14 professionals professional NNS cord-253196-et1ekgdl 38 15 who who WP cord-253196-et1ekgdl 38 16 are be VBP cord-253196-et1ekgdl 38 17 depleting deplete VBG cord-253196-et1ekgdl 38 18 supply supply NN cord-253196-et1ekgdl 38 19 by by IN cord-253196-et1ekgdl 38 20 prescribing prescribe VBG cord-253196-et1ekgdl 38 21 antimalarials antimalarial NNS cord-253196-et1ekgdl 38 22 for for IN cord-253196-et1ekgdl 38 23 preexposure preexposure NN cord-253196-et1ekgdl 38 24 prophylaxis prophylaxis NN cord-253196-et1ekgdl 38 25 . . . cord-253196-et1ekgdl 39 1 Hoarding hoarding NN cord-253196-et1ekgdl 39 2 by by IN cord-253196-et1ekgdl 39 3 health health NN cord-253196-et1ekgdl 39 4 professionals professional NNS cord-253196-et1ekgdl 39 5 for for IN cord-253196-et1ekgdl 39 6 themselves -PRON- PRP cord-253196-et1ekgdl 39 7 and and CC cord-253196-et1ekgdl 39 8 their -PRON- PRP$ cord-253196-et1ekgdl 39 9 friends friend NNS cord-253196-et1ekgdl 39 10 or or CC cord-253196-et1ekgdl 39 11 family family NN cord-253196-et1ekgdl 39 12 is be VBZ cord-253196-et1ekgdl 39 13 already already RB cord-253196-et1ekgdl 39 14 occurring occur VBG cord-253196-et1ekgdl 39 15 , , , cord-253196-et1ekgdl 39 16 but but CC cord-253196-et1ekgdl 39 17 state state NN cord-253196-et1ekgdl 39 18 governments government NNS cord-253196-et1ekgdl 39 19 and and CC cord-253196-et1ekgdl 39 20 pharmacy pharmacy NN cord-253196-et1ekgdl 39 21 boards board NNS cord-253196-et1ekgdl 39 22 have have VBP cord-253196-et1ekgdl 39 23 started start VBN cord-253196-et1ekgdl 39 24 to to TO cord-253196-et1ekgdl 39 25 institute institute VB cord-253196-et1ekgdl 39 26 strict strict JJ cord-253196-et1ekgdl 39 27 utilization utilization NN cord-253196-et1ekgdl 39 28 policies policy NNS cord-253196-et1ekgdl 39 29 to to TO cord-253196-et1ekgdl 39 30 prevent prevent VB cord-253196-et1ekgdl 39 31 further further JJ cord-253196-et1ekgdl 39 32 HCQ hcq NN cord-253196-et1ekgdl 39 33 overutilization overutilization NN cord-253196-et1ekgdl 39 34 . . . cord-253196-et1ekgdl 40 1 Meanwhile meanwhile RB cord-253196-et1ekgdl 40 2 , , , cord-253196-et1ekgdl 40 3 multiple multiple JJ cord-253196-et1ekgdl 40 4 manufacturers manufacturer NNS cord-253196-et1ekgdl 40 5 have have VBP cord-253196-et1ekgdl 40 6 already already RB cord-253196-et1ekgdl 40 7 made make VBN cord-253196-et1ekgdl 40 8 critical critical JJ cord-253196-et1ekgdl 40 9 commitments commitment NNS cord-253196-et1ekgdl 40 10 to to TO cord-253196-et1ekgdl 40 11 initiate initiate VB cord-253196-et1ekgdl 40 12 or or CC cord-253196-et1ekgdl 40 13 increase increase VB cord-253196-et1ekgdl 40 14 production production NN cord-253196-et1ekgdl 40 15 of of IN cord-253196-et1ekgdl 40 16 HCQ HCQ NNP cord-253196-et1ekgdl 40 17 . . . cord-253196-et1ekgdl 41 1 What what WDT cord-253196-et1ekgdl 41 2 advice advice NN cord-253196-et1ekgdl 41 3 should should MD cord-253196-et1ekgdl 41 4 clinicians clinician NNS cord-253196-et1ekgdl 41 5 give give VB cord-253196-et1ekgdl 41 6 to to IN cord-253196-et1ekgdl 41 7 patients patient NNS cord-253196-et1ekgdl 41 8 with with IN cord-253196-et1ekgdl 41 9 SLE SLE NNP cord-253196-et1ekgdl 41 10 or or CC cord-253196-et1ekgdl 41 11 RA RA NNP cord-253196-et1ekgdl 41 12 who who WP cord-253196-et1ekgdl 41 13 have have VBP cord-253196-et1ekgdl 41 14 difficulty difficulty NN cord-253196-et1ekgdl 41 15 securing secure VBG cord-253196-et1ekgdl 41 16 HCQ HCQ NNP cord-253196-et1ekgdl 41 17 ? ? . cord-253196-et1ekgdl 42 1 The the DT cord-253196-et1ekgdl 42 2 pharmacokinetics pharmacokinetic NNS cord-253196-et1ekgdl 42 3 of of IN cord-253196-et1ekgdl 42 4 HCQ HCQ NNP cord-253196-et1ekgdl 42 5 are be VBP cord-253196-et1ekgdl 42 6 an an DT cord-253196-et1ekgdl 42 7 important important JJ cord-253196-et1ekgdl 42 8 consideration consideration NN cord-253196-et1ekgdl 42 9 in in IN cord-253196-et1ekgdl 42 10 answering answer VBG cord-253196-et1ekgdl 42 11 this this DT cord-253196-et1ekgdl 42 12 question question NN cord-253196-et1ekgdl 42 13 . . . cord-253196-et1ekgdl 43 1 With with IN cord-253196-et1ekgdl 43 2 long long JJ cord-253196-et1ekgdl 43 3 - - HYPH cord-253196-et1ekgdl 43 4 term term NN cord-253196-et1ekgdl 43 5 use use NN cord-253196-et1ekgdl 43 6 of of IN cord-253196-et1ekgdl 43 7 HCQ HCQ NNP cord-253196-et1ekgdl 43 8 , , , cord-253196-et1ekgdl 43 9 peak peak NN cord-253196-et1ekgdl 43 10 plasma plasma NN cord-253196-et1ekgdl 43 11 levels level NNS cord-253196-et1ekgdl 43 12 occur occur VBP cord-253196-et1ekgdl 43 13 3 3 CD cord-253196-et1ekgdl 43 14 to to TO cord-253196-et1ekgdl 43 15 4 4 CD cord-253196-et1ekgdl 43 16 hours hour NNS cord-253196-et1ekgdl 43 17 after after IN cord-253196-et1ekgdl 43 18 each each DT cord-253196-et1ekgdl 43 19 dose dose NN cord-253196-et1ekgdl 43 20 , , , cord-253196-et1ekgdl 43 21 with with IN cord-253196-et1ekgdl 43 22 a a DT cord-253196-et1ekgdl 43 23 terminal terminal JJ cord-253196-et1ekgdl 43 24 half half JJ cord-253196-et1ekgdl 43 25 - - HYPH cord-253196-et1ekgdl 43 26 life life NN cord-253196-et1ekgdl 43 27 of of IN cord-253196-et1ekgdl 43 28 40 40 CD cord-253196-et1ekgdl 43 29 to to TO cord-253196-et1ekgdl 43 30 50 50 CD cord-253196-et1ekgdl 43 31 days day NNS cord-253196-et1ekgdl 43 32 ( ( -LRB- cord-253196-et1ekgdl 43 33 9 9 CD cord-253196-et1ekgdl 43 34 ) ) -RRB- cord-253196-et1ekgdl 43 35 . . . cord-253196-et1ekgdl 44 1 The the DT cord-253196-et1ekgdl 44 2 long long JJ cord-253196-et1ekgdl 44 3 half half JJ cord-253196-et1ekgdl 44 4 - - HYPH cord-253196-et1ekgdl 44 5 life life NN cord-253196-et1ekgdl 44 6 means mean VBZ cord-253196-et1ekgdl 44 7 that that IN cord-253196-et1ekgdl 44 8 brief brief JJ cord-253196-et1ekgdl 44 9 gaps gap NNS cord-253196-et1ekgdl 44 10 in in IN cord-253196-et1ekgdl 44 11 therapy therapy NN cord-253196-et1ekgdl 44 12 , , , cord-253196-et1ekgdl 44 13 on on IN cord-253196-et1ekgdl 44 14 the the DT cord-253196-et1ekgdl 44 15 order order NN cord-253196-et1ekgdl 44 16 of of IN cord-253196-et1ekgdl 44 17 1 1 CD cord-253196-et1ekgdl 44 18 to to IN cord-253196-et1ekgdl 44 19 2 2 CD cord-253196-et1ekgdl 44 20 weeks week NNS cord-253196-et1ekgdl 44 21 , , , cord-253196-et1ekgdl 44 22 are be VBP cord-253196-et1ekgdl 44 23 less less RBR cord-253196-et1ekgdl 44 24 concerning concern VBG cord-253196-et1ekgdl 44 25 . . . cord-253196-et1ekgdl 45 1 However however RB cord-253196-et1ekgdl 45 2 , , , cord-253196-et1ekgdl 45 3 longer long JJR cord-253196-et1ekgdl 45 4 treatment treatment NN cord-253196-et1ekgdl 45 5 lapses lapse NNS cord-253196-et1ekgdl 45 6 put put VBP cord-253196-et1ekgdl 45 7 patients patient NNS cord-253196-et1ekgdl 45 8 at at IN cord-253196-et1ekgdl 45 9 risk risk NN cord-253196-et1ekgdl 45 10 for for IN cord-253196-et1ekgdl 45 11 disease disease NN cord-253196-et1ekgdl 45 12 exacerbations exacerbation NNS cord-253196-et1ekgdl 45 13 , , , cord-253196-et1ekgdl 45 14 given give VBN cord-253196-et1ekgdl 45 15 studies study NNS cord-253196-et1ekgdl 45 16 showing show VBG cord-253196-et1ekgdl 45 17 that that IN cord-253196-et1ekgdl 45 18 lower low JJR cord-253196-et1ekgdl 45 19 plasma plasma NN cord-253196-et1ekgdl 45 20 con con NN cord-253196-et1ekgdl 45 21 - - : cord-253196-et1ekgdl 45 22 This this DT cord-253196-et1ekgdl 45 23 article article NN cord-253196-et1ekgdl 45 24 was be VBD cord-253196-et1ekgdl 45 25 published publish VBN cord-253196-et1ekgdl 45 26 at at IN cord-253196-et1ekgdl 45 27 Annals.org Annals.org NNP cord-253196-et1ekgdl 45 28 on on IN cord-253196-et1ekgdl 45 29 31 31 CD cord-253196-et1ekgdl 45 30 March March NNP cord-253196-et1ekgdl 45 31 2020 2020 CD cord-253196-et1ekgdl 45 32 . . . cord-253196-et1ekgdl 46 1 centrations centrations NNP cord-253196-et1ekgdl 46 2 of of IN cord-253196-et1ekgdl 46 3 HCQ HCQ NNP cord-253196-et1ekgdl 46 4 correlate correlate VBP cord-253196-et1ekgdl 46 5 with with IN cord-253196-et1ekgdl 46 6 more more JJR cord-253196-et1ekgdl 46 7 SLE SLE NNP cord-253196-et1ekgdl 46 8 disease disease NN cord-253196-et1ekgdl 46 9 activity activity NN cord-253196-et1ekgdl 46 10 ( ( -LRB- cord-253196-et1ekgdl 46 11 10 10 CD cord-253196-et1ekgdl 46 12 ) ) -RRB- cord-253196-et1ekgdl 46 13 . . . cord-253196-et1ekgdl 47 1 In in IN cord-253196-et1ekgdl 47 2 addition addition NN cord-253196-et1ekgdl 47 3 , , , cord-253196-et1ekgdl 47 4 in in IN cord-253196-et1ekgdl 47 5 a a DT cord-253196-et1ekgdl 47 6 well well RB cord-253196-et1ekgdl 47 7 - - HYPH cord-253196-et1ekgdl 47 8 designed design VBN cord-253196-et1ekgdl 47 9 clinical clinical JJ cord-253196-et1ekgdl 47 10 trial trial NN cord-253196-et1ekgdl 47 11 , , , cord-253196-et1ekgdl 47 12 a a DT cord-253196-et1ekgdl 47 13 higher high JJR cord-253196-et1ekgdl 47 14 incidence incidence NN cord-253196-et1ekgdl 47 15 of of IN cord-253196-et1ekgdl 47 16 SLE SLE NNP cord-253196-et1ekgdl 47 17 flares flare NNS cord-253196-et1ekgdl 47 18 was be VBD cord-253196-et1ekgdl 47 19 seen see VBN cord-253196-et1ekgdl 47 20 as as RB cord-253196-et1ekgdl 47 21 soon soon RB cord-253196-et1ekgdl 47 22 as as IN cord-253196-et1ekgdl 47 23 2 2 CD cord-253196-et1ekgdl 47 24 weeks week NNS cord-253196-et1ekgdl 47 25 after after IN cord-253196-et1ekgdl 47 26 the the DT cord-253196-et1ekgdl 47 27 drug drug NN cord-253196-et1ekgdl 47 28 was be VBD cord-253196-et1ekgdl 47 29 stopped stop VBN cord-253196-et1ekgdl 47 30 ( ( -LRB- cord-253196-et1ekgdl 47 31 8) 8) NNP cord-253196-et1ekgdl 47 32 . . . cord-253196-et1ekgdl 48 1 Patients patient NNS cord-253196-et1ekgdl 48 2 may may MD cord-253196-et1ekgdl 48 3 also also RB cord-253196-et1ekgdl 48 4 wonder wonder VB cord-253196-et1ekgdl 48 5 whether whether IN cord-253196-et1ekgdl 48 6 rationing ration VBG cord-253196-et1ekgdl 48 7 their -PRON- PRP$ cord-253196-et1ekgdl 48 8 supply supply NN cord-253196-et1ekgdl 48 9 by by IN cord-253196-et1ekgdl 48 10 halving halve VBG cord-253196-et1ekgdl 48 11 their -PRON- PRP$ cord-253196-et1ekgdl 48 12 current current JJ cord-253196-et1ekgdl 48 13 dose dose NN cord-253196-et1ekgdl 48 14 is be VBZ cord-253196-et1ekgdl 48 15 a a DT cord-253196-et1ekgdl 48 16 good good JJ cord-253196-et1ekgdl 48 17 approach approach NN cord-253196-et1ekgdl 48 18 . . . cord-253196-et1ekgdl 49 1 Studies study NNS cord-253196-et1ekgdl 49 2 show show VBP cord-253196-et1ekgdl 49 3 significant significant JJ cord-253196-et1ekgdl 49 4 heterogeneity heterogeneity NN cord-253196-et1ekgdl 49 5 in in IN cord-253196-et1ekgdl 49 6 plasma plasma NN cord-253196-et1ekgdl 49 7 concentrations concentration NNS cord-253196-et1ekgdl 49 8 of of IN cord-253196-et1ekgdl 49 9 HCQ HCQ NNP cord-253196-et1ekgdl 49 10 , , , cord-253196-et1ekgdl 49 11 even even RB cord-253196-et1ekgdl 49 12 when when WRB cord-253196-et1ekgdl 49 13 standard standard JJ cord-253196-et1ekgdl 49 14 doses dose NNS cord-253196-et1ekgdl 49 15 of of IN cord-253196-et1ekgdl 49 16 approximately approximately RB cord-253196-et1ekgdl 49 17 5 5 CD cord-253196-et1ekgdl 49 18 mg mg NNP cord-253196-et1ekgdl 49 19 / / SYM cord-253196-et1ekgdl 49 20 kg kg NNS cord-253196-et1ekgdl 49 21 are be VBP cord-253196-et1ekgdl 49 22 used use VBN cord-253196-et1ekgdl 49 23 ( ( -LRB- cord-253196-et1ekgdl 49 24 9 9 CD cord-253196-et1ekgdl 49 25 ) ) -RRB- cord-253196-et1ekgdl 49 26 . . . cord-253196-et1ekgdl 50 1 Therefore therefore RB cord-253196-et1ekgdl 50 2 , , , cord-253196-et1ekgdl 50 3 some some DT cord-253196-et1ekgdl 50 4 patients patient NNS cord-253196-et1ekgdl 50 5 may may MD cord-253196-et1ekgdl 50 6 do do VB cord-253196-et1ekgdl 50 7 better well RBR cord-253196-et1ekgdl 50 8 than than IN cord-253196-et1ekgdl 50 9 others other NNS cord-253196-et1ekgdl 50 10 with with IN cord-253196-et1ekgdl 50 11 this this DT cord-253196-et1ekgdl 50 12 approach approach NN cord-253196-et1ekgdl 50 13 . . . cord-253196-et1ekgdl 51 1 The the DT cord-253196-et1ekgdl 51 2 looming loom VBG cord-253196-et1ekgdl 51 3 public public JJ cord-253196-et1ekgdl 51 4 health health NN cord-253196-et1ekgdl 51 5 crisis crisis NN cord-253196-et1ekgdl 51 6 for for IN cord-253196-et1ekgdl 51 7 people people NNS cord-253196-et1ekgdl 51 8 with with IN cord-253196-et1ekgdl 51 9 rheumatic rheumatic JJ cord-253196-et1ekgdl 51 10 diseases disease NNS cord-253196-et1ekgdl 51 11 who who WP cord-253196-et1ekgdl 51 12 will will MD cord-253196-et1ekgdl 51 13 be be VB cord-253196-et1ekgdl 51 14 unable unable JJ cord-253196-et1ekgdl 51 15 to to TO cord-253196-et1ekgdl 51 16 obtain obtain VB cord-253196-et1ekgdl 51 17 HCQ HCQ NNP cord-253196-et1ekgdl 51 18 is be VBZ cord-253196-et1ekgdl 51 19 the the DT cord-253196-et1ekgdl 51 20 result result NN cord-253196-et1ekgdl 51 21 of of IN cord-253196-et1ekgdl 51 22 a a DT cord-253196-et1ekgdl 51 23 perfect perfect JJ cord-253196-et1ekgdl 51 24 storm storm NN cord-253196-et1ekgdl 51 25 of of IN cord-253196-et1ekgdl 51 26 fear fear NN cord-253196-et1ekgdl 51 27 and and CC cord-253196-et1ekgdl 51 28 dissemination dissemination NN cord-253196-et1ekgdl 51 29 of of IN cord-253196-et1ekgdl 51 30 overpromised overpromise VBN cord-253196-et1ekgdl 51 31 data datum NNS cord-253196-et1ekgdl 51 32 . . . cord-253196-et1ekgdl 52 1 However however RB cord-253196-et1ekgdl 52 2 , , , cord-253196-et1ekgdl 52 3 there there EX cord-253196-et1ekgdl 52 4 is be VBZ cord-253196-et1ekgdl 52 5 still still RB cord-253196-et1ekgdl 52 6 time time NN cord-253196-et1ekgdl 52 7 to to TO cord-253196-et1ekgdl 52 8 mitigate mitigate VB cord-253196-et1ekgdl 52 9 the the DT cord-253196-et1ekgdl 52 10 damage damage NN cord-253196-et1ekgdl 52 11 . . . cord-253196-et1ekgdl 53 1 Physicians physician NNS cord-253196-et1ekgdl 53 2 should should MD cord-253196-et1ekgdl 53 3 educate educate VB cord-253196-et1ekgdl 53 4 themselves -PRON- PRP cord-253196-et1ekgdl 53 5 about about IN cord-253196-et1ekgdl 53 6 the the DT cord-253196-et1ekgdl 53 7 strength strength NN cord-253196-et1ekgdl 53 8 of of IN cord-253196-et1ekgdl 53 9 available available JJ cord-253196-et1ekgdl 53 10 data datum NNS cord-253196-et1ekgdl 53 11 regarding regard VBG cord-253196-et1ekgdl 53 12 HCQ HCQ NNP cord-253196-et1ekgdl 53 13 and and CC cord-253196-et1ekgdl 53 14 CQ CQ NNP cord-253196-et1ekgdl 53 15 in in IN cord-253196-et1ekgdl 53 16 treating treat VBG cord-253196-et1ekgdl 53 17 COVID-19 covid-19 NN cord-253196-et1ekgdl 53 18 . . . cord-253196-et1ekgdl 54 1 They -PRON- PRP cord-253196-et1ekgdl 54 2 should should MD cord-253196-et1ekgdl 54 3 avoid avoid VB cord-253196-et1ekgdl 54 4 misuse misuse NN cord-253196-et1ekgdl 54 5 of of IN cord-253196-et1ekgdl 54 6 HCQ HCQ NNP cord-253196-et1ekgdl 54 7 and and CC cord-253196-et1ekgdl 54 8 CQ CQ NNP cord-253196-et1ekgdl 54 9 for for IN cord-253196-et1ekgdl 54 10 the the DT cord-253196-et1ekgdl 54 11 prophylaxis prophylaxis NN cord-253196-et1ekgdl 54 12 of of IN cord-253196-et1ekgdl 54 13 COVID-19 COVID-19 NNP cord-253196-et1ekgdl 54 14 , , , cord-253196-et1ekgdl 54 15 because because IN cord-253196-et1ekgdl 54 16 there there EX cord-253196-et1ekgdl 54 17 are be VBP cord-253196-et1ekgdl 54 18 absolutely absolutely RB cord-253196-et1ekgdl 54 19 no no DT cord-253196-et1ekgdl 54 20 data data NN cord-253196-et1ekgdl 54 21 to to TO cord-253196-et1ekgdl 54 22 support support VB cord-253196-et1ekgdl 54 23 this this DT cord-253196-et1ekgdl 54 24 . . . cord-253196-et1ekgdl 55 1 Public public JJ cord-253196-et1ekgdl 55 2 figures figure NNS cord-253196-et1ekgdl 55 3 should should MD cord-253196-et1ekgdl 55 4 refrain refrain VB cord-253196-et1ekgdl 55 5 from from IN cord-253196-et1ekgdl 55 6 promoting promote VBG cord-253196-et1ekgdl 55 7 unproven unproven JJ cord-253196-et1ekgdl 55 8 therapies therapy NNS cord-253196-et1ekgdl 55 9 to to IN cord-253196-et1ekgdl 55 10 the the DT cord-253196-et1ekgdl 55 11 public public NN cord-253196-et1ekgdl 55 12 , , , cord-253196-et1ekgdl 55 13 and and CC cord-253196-et1ekgdl 55 14 instead instead RB cord-253196-et1ekgdl 55 15 provide provide VB cord-253196-et1ekgdl 55 16 clear clear JJ cord-253196-et1ekgdl 55 17 messages message NNS cord-253196-et1ekgdl 55 18 around around IN cord-253196-et1ekgdl 55 19 the the DT cord-253196-et1ekgdl 55 20 uncertainties uncertainty NNS cord-253196-et1ekgdl 55 21 we -PRON- PRP cord-253196-et1ekgdl 55 22 face face VBP cord-253196-et1ekgdl 55 23 in in IN cord-253196-et1ekgdl 55 24 testing testing NN cord-253196-et1ekgdl 55 25 and and CC cord-253196-et1ekgdl 55 26 using use VBG cord-253196-et1ekgdl 55 27 experimental experimental JJ cord-253196-et1ekgdl 55 28 treatments treatment NNS cord-253196-et1ekgdl 55 29 during during IN cord-253196-et1ekgdl 55 30 the the DT cord-253196-et1ekgdl 55 31 current current JJ cord-253196-et1ekgdl 55 32 pandemic pandemic NN cord-253196-et1ekgdl 55 33 , , , cord-253196-et1ekgdl 55 34 including include VBG cord-253196-et1ekgdl 55 35 the the DT cord-253196-et1ekgdl 55 36 risk risk NN cord-253196-et1ekgdl 55 37 for for IN cord-253196-et1ekgdl 55 38 serious serious JJ cord-253196-et1ekgdl 55 39 adverse adverse JJ cord-253196-et1ekgdl 55 40 events event NNS cord-253196-et1ekgdl 55 41 . . . cord-253196-et1ekgdl 56 1 Well well RB cord-253196-et1ekgdl 56 2 - - HYPH cord-253196-et1ekgdl 56 3 done do VBN cord-253196-et1ekgdl 56 4 , , , cord-253196-et1ekgdl 56 5 randomized randomized JJ cord-253196-et1ekgdl 56 6 clinical clinical JJ cord-253196-et1ekgdl 56 7 trials trial NNS cord-253196-et1ekgdl 56 8 should should MD cord-253196-et1ekgdl 56 9 be be VB cord-253196-et1ekgdl 56 10 performed perform VBN cord-253196-et1ekgdl 56 11 urgently urgently RB cord-253196-et1ekgdl 56 12 to to TO cord-253196-et1ekgdl 56 13 test test VB cord-253196-et1ekgdl 56 14 potential potential JJ cord-253196-et1ekgdl 56 15 therapies therapy NNS cord-253196-et1ekgdl 56 16 , , , cord-253196-et1ekgdl 56 17 including include VBG cord-253196-et1ekgdl 56 18 HCQ HCQ NNP cord-253196-et1ekgdl 56 19 . . . cord-253196-et1ekgdl 57 1 In in IN cord-253196-et1ekgdl 57 2 the the DT cord-253196-et1ekgdl 57 3 meantime meantime NN cord-253196-et1ekgdl 57 4 , , , cord-253196-et1ekgdl 57 5 physicians physician NNS cord-253196-et1ekgdl 57 6 should should MD cord-253196-et1ekgdl 57 7 remember remember VB cord-253196-et1ekgdl 57 8 that that IN cord-253196-et1ekgdl 57 9 first first RB cord-253196-et1ekgdl 57 10 , , , cord-253196-et1ekgdl 57 11 we -PRON- PRP cord-253196-et1ekgdl 57 12 must must MD cord-253196-et1ekgdl 57 13 do do VB cord-253196-et1ekgdl 57 14 no no DT cord-253196-et1ekgdl 57 15 harm harm NN cord-253196-et1ekgdl 57 16 to to IN cord-253196-et1ekgdl 57 17 the the DT cord-253196-et1ekgdl 57 18 patients patient NNS cord-253196-et1ekgdl 57 19 with with IN cord-253196-et1ekgdl 57 20 rheumatic rheumatic JJ cord-253196-et1ekgdl 57 21 disease disease NN cord-253196-et1ekgdl 57 22 for for IN cord-253196-et1ekgdl 57 23 whom whom WP cord-253196-et1ekgdl 57 24 high high JJ cord-253196-et1ekgdl 57 25 - - HYPH cord-253196-et1ekgdl 57 26 quality quality NN cord-253196-et1ekgdl 57 27 evidence evidence NN cord-253196-et1ekgdl 57 28 shows show VBZ cord-253196-et1ekgdl 57 29 that that IN cord-253196-et1ekgdl 57 30 HCQ HCQ NNP cord-253196-et1ekgdl 57 31 improves improve VBZ cord-253196-et1ekgdl 57 32 health health NN cord-253196-et1ekgdl 57 33 . . . cord-253196-et1ekgdl 57 34 _SP cord-253196-et1ekgdl 58 1 Hydroxychloroquine Hydroxychloroquine NNP cord-253196-et1ekgdl 58 2 , , , cord-253196-et1ekgdl 58 3 a a DT cord-253196-et1ekgdl 58 4 less less RBR cord-253196-et1ekgdl 58 5 toxic toxic JJ cord-253196-et1ekgdl 58 6 derivative derivative NN cord-253196-et1ekgdl 58 7 of of IN cord-253196-et1ekgdl 58 8 chloroquine chloroquine NN cord-253196-et1ekgdl 58 9 , , , cord-253196-et1ekgdl 58 10 is be VBZ cord-253196-et1ekgdl 58 11 effective effective JJ cord-253196-et1ekgdl 58 12 in in IN cord-253196-et1ekgdl 58 13 inhibiting inhibit VBG cord-253196-et1ekgdl 58 14 SARS SARS NNP cord-253196-et1ekgdl 58 15 - - HYPH cord-253196-et1ekgdl 58 16 CoV-2 CoV-2 NNP cord-253196-et1ekgdl 58 17 infection infection NN cord-253196-et1ekgdl 59 1 in in IN cord-253196-et1ekgdl 59 2 vitro vitro FW cord-253196-et1ekgdl 60 1 In in IN cord-253196-et1ekgdl 60 2 vitro vitro FW cord-253196-et1ekgdl 60 3 antiviral antiviral JJ cord-253196-et1ekgdl 60 4 activity activity NN cord-253196-et1ekgdl 60 5 and and CC cord-253196-et1ekgdl 60 6 projection projection NN cord-253196-et1ekgdl 60 7 of of IN cord-253196-et1ekgdl 60 8 optimized optimize VBN cord-253196-et1ekgdl 60 9 dosing dosing NN cord-253196-et1ekgdl 60 10 design design NN cord-253196-et1ekgdl 60 11 of of IN cord-253196-et1ekgdl 60 12 hydroxychloroquine hydroxychloroquine NN cord-253196-et1ekgdl 60 13 for for IN cord-253196-et1ekgdl 60 14 the the DT cord-253196-et1ekgdl 60 15 treatment treatment NN cord-253196-et1ekgdl 60 16 of of IN cord-253196-et1ekgdl 60 17 severe severe JJ cord-253196-et1ekgdl 60 18 acute acute JJ cord-253196-et1ekgdl 60 19 respiratory respiratory JJ cord-253196-et1ekgdl 60 20 syndrome syndrome NN cord-253196-et1ekgdl 60 21 coronavirus coronavirus NN cord-253196-et1ekgdl 60 22 Hydroxychloroquine Hydroxychloroquine NNP cord-253196-et1ekgdl 60 23 and and CC cord-253196-et1ekgdl 60 24 azithromycin azithromycin NNP cord-253196-et1ekgdl 60 25 as as IN cord-253196-et1ekgdl 60 26 a a DT cord-253196-et1ekgdl 60 27 treatment treatment NN cord-253196-et1ekgdl 60 28 of of IN cord-253196-et1ekgdl 60 29 COVID-19 covid-19 NN cord-253196-et1ekgdl 60 30 : : : cord-253196-et1ekgdl 60 31 results result NNS cord-253196-et1ekgdl 60 32 of of IN cord-253196-et1ekgdl 60 33 an an DT cord-253196-et1ekgdl 60 34 open open JJ cord-253196-et1ekgdl 60 35 - - HYPH cord-253196-et1ekgdl 60 36 label label NN cord-253196-et1ekgdl 60 37 nonrandomized nonrandomize VBN cord-253196-et1ekgdl 60 38 clinical clinical JJ cord-253196-et1ekgdl 60 39 trial trial NN cord-253196-et1ekgdl 60 40 Chloroquine Chloroquine NNP cord-253196-et1ekgdl 60 41 for for IN cord-253196-et1ekgdl 60 42 influenza influenza NN cord-253196-et1ekgdl 60 43 prevention prevention NN cord-253196-et1ekgdl 60 44 : : : cord-253196-et1ekgdl 60 45 a a DT cord-253196-et1ekgdl 60 46 randomised randomised JJ cord-253196-et1ekgdl 60 47 , , , cord-253196-et1ekgdl 60 48 double double JJ cord-253196-et1ekgdl 60 49 - - HYPH cord-253196-et1ekgdl 60 50 blind blind JJ cord-253196-et1ekgdl 60 51 , , , cord-253196-et1ekgdl 60 52 placebo placebo NN cord-253196-et1ekgdl 60 53 controlled control VBN cord-253196-et1ekgdl 60 54 trial trial NN cord-253196-et1ekgdl 60 55 In in IN cord-253196-et1ekgdl 60 56 vitro vitro FW cord-253196-et1ekgdl 60 57 inhibition inhibition NN cord-253196-et1ekgdl 60 58 of of IN cord-253196-et1ekgdl 60 59 human human JJ cord-253196-et1ekgdl 60 60 influenza influenza NN cord-253196-et1ekgdl 60 61 A a DT cord-253196-et1ekgdl 60 62 virus virus NN cord-253196-et1ekgdl 60 63 replication replication NN cord-253196-et1ekgdl 60 64 by by IN cord-253196-et1ekgdl 60 65 chloroquine chloroquine NNP cord-253196-et1ekgdl 60 66 COVID-19 COVID-19 NNP cord-253196-et1ekgdl 60 67 Global Global NNP cord-253196-et1ekgdl 60 68 Rheumatology Rheumatology NNP cord-253196-et1ekgdl 60 69 Alliance Alliance NNP cord-253196-et1ekgdl 60 70 . . . cord-253196-et1ekgdl 61 1 A a DT cord-253196-et1ekgdl 61 2 rush rush NN cord-253196-et1ekgdl 61 3 to to IN cord-253196-et1ekgdl 61 4 judgment judgment NN cord-253196-et1ekgdl 61 5 ? ? . cord-253196-et1ekgdl 62 1 Rapid rapid JJ cord-253196-et1ekgdl 62 2 reporting reporting NN cord-253196-et1ekgdl 62 3 and and CC cord-253196-et1ekgdl 62 4 dissemination dissemination NN cord-253196-et1ekgdl 62 5 of of IN cord-253196-et1ekgdl 62 6 results result NNS cord-253196-et1ekgdl 62 7 and and CC cord-253196-et1ekgdl 62 8 its -PRON- PRP$ cord-253196-et1ekgdl 62 9 consequences consequence NNS cord-253196-et1ekgdl 62 10 regarding regard VBG cord-253196-et1ekgdl 62 11 the the DT cord-253196-et1ekgdl 62 12 use use NN cord-253196-et1ekgdl 62 13 of of IN cord-253196-et1ekgdl 62 14 hydroxychloroquine hydroxychloroquine NN cord-253196-et1ekgdl 62 15 for for IN cord-253196-et1ekgdl 62 16 COVID-19 COVID-19 NNP cord-253196-et1ekgdl 62 17 A a DT cord-253196-et1ekgdl 62 18 pilot pilot NN cord-253196-et1ekgdl 62 19 study study NN cord-253196-et1ekgdl 62 20 of of IN cord-253196-et1ekgdl 62 21 hydroxychloroquine hydroxychloroquine NNP cord-253196-et1ekgdl 62 22 in in IN cord-253196-et1ekgdl 62 23 treatment treatment NN cord-253196-et1ekgdl 62 24 of of IN cord-253196-et1ekgdl 62 25 patients patient NNS cord-253196-et1ekgdl 62 26 with with IN cord-253196-et1ekgdl 62 27 common common JJ cord-253196-et1ekgdl 62 28 coronavirus coronavirus NN cord-253196-et1ekgdl 62 29 disease-19 disease-19 , cord-253196-et1ekgdl 62 30 ( ( -LRB- cord-253196-et1ekgdl 62 31 COVID-19 COVID-19 NNP cord-253196-et1ekgdl 62 32 ) ) -RRB- cord-253196-et1ekgdl 62 33 A a DT cord-253196-et1ekgdl 62 34 randomized randomized JJ cord-253196-et1ekgdl 62 35 study study NN cord-253196-et1ekgdl 62 36 of of IN cord-253196-et1ekgdl 62 37 the the DT cord-253196-et1ekgdl 62 38 effect effect NN cord-253196-et1ekgdl 62 39 of of IN cord-253196-et1ekgdl 62 40 withdrawing withdraw VBG cord-253196-et1ekgdl 62 41 hydroxychloroquine hydroxychloroquine NN cord-253196-et1ekgdl 62 42 sulfate sulfate NN cord-253196-et1ekgdl 62 43 in in IN cord-253196-et1ekgdl 62 44 systemic systemic JJ cord-253196-et1ekgdl 62 45 lupus lupus NN cord-253196-et1ekgdl 62 46 erythematosus erythematosus NN cord-253196-et1ekgdl 62 47 Mechanisms Mechanisms NNPS cord-253196-et1ekgdl 62 48 of of IN cord-253196-et1ekgdl 62 49 action action NN cord-253196-et1ekgdl 62 50 of of IN cord-253196-et1ekgdl 62 51 hydroxychloroquine hydroxychloroquine NNP cord-253196-et1ekgdl 62 52 and and CC cord-253196-et1ekgdl 62 53 chloroquine chloroquine NN cord-253196-et1ekgdl 62 54 : : : cord-253196-et1ekgdl 62 55 implications implication NNS cord-253196-et1ekgdl 62 56 for for IN cord-253196-et1ekgdl 62 57 rheumatology rheumatology NN cord-253196-et1ekgdl 62 58 Low low JJ cord-253196-et1ekgdl 62 59 blood blood NN cord-253196-et1ekgdl 62 60 concentration concentration NN cord-253196-et1ekgdl 62 61 of of IN cord-253196-et1ekgdl 62 62 hydroxychloroquine hydroxychloroquine NN cord-253196-et1ekgdl 62 63 is be VBZ cord-253196-et1ekgdl 62 64 a a DT cord-253196-et1ekgdl 62 65 marker marker NN cord-253196-et1ekgdl 62 66 for for IN cord-253196-et1ekgdl 62 67 and and CC cord-253196-et1ekgdl 62 68 predictor predictor NN cord-253196-et1ekgdl 62 69 of of IN cord-253196-et1ekgdl 62 70 disease disease NN cord-253196-et1ekgdl 62 71 exacerbations exacerbation NNS cord-253196-et1ekgdl 62 72 in in IN cord-253196-et1ekgdl 62 73 patients patient NNS cord-253196-et1ekgdl 62 74 with with IN cord-253196-et1ekgdl 62 75 systemic systemic JJ cord-253196-et1ekgdl 62 76 lupus lupus NN cord-253196-et1ekgdl 62 77 erythematosus erythematosus NN cord-253196-et1ekgdl 63 1 The the DT cord-253196-et1ekgdl 63 2 authors author NNS cord-253196-et1ekgdl 63 3 thank thank VBP cord-253196-et1ekgdl 63 4 the the DT cord-253196-et1ekgdl 63 5 members member NNS cord-253196-et1ekgdl 63 6 of of IN cord-253196-et1ekgdl 63 7 the the DT