id sid tid token lemma pos cord-028034-pjotppso 1 1 key key NNP cord-028034-pjotppso 1 2 : : : cord-028034-pjotppso 1 3 cord-028034-pjotppso cord-028034-pjotppso NNP cord-028034-pjotppso 2 1 authors author NNS cord-028034-pjotppso 2 2 : : : cord-028034-pjotppso 2 3 Kang Kang NNP cord-028034-pjotppso 2 4 , , , cord-028034-pjotppso 2 5 Jian‐Sheng Jian‐Sheng NNP cord-028034-pjotppso 2 6 title title NN cord-028034-pjotppso 2 7 : : : cord-028034-pjotppso 2 8 Vitamin vitamin NN cord-028034-pjotppso 2 9 intervention intervention NN cord-028034-pjotppso 2 10 for for IN cord-028034-pjotppso 2 11 cytokine cytokine NN cord-028034-pjotppso 2 12 storm storm NN cord-028034-pjotppso 2 13 in in IN cord-028034-pjotppso 2 14 the the DT cord-028034-pjotppso 2 15 patients patient NNS cord-028034-pjotppso 2 16 with with IN cord-028034-pjotppso 2 17 coronavirus coronavirus NN cord-028034-pjotppso 2 18 disease disease NN cord-028034-pjotppso 2 19 2019 2019 CD cord-028034-pjotppso 2 20 date date NN cord-028034-pjotppso 2 21 : : : cord-028034-pjotppso 2 22 2020 2020 CD cord-028034-pjotppso 2 23 - - HYPH cord-028034-pjotppso 2 24 06 06 CD cord-028034-pjotppso 2 25 - - SYM cord-028034-pjotppso 2 26 19 19 CD cord-028034-pjotppso 2 27 journal journal NN cord-028034-pjotppso 2 28 : : : cord-028034-pjotppso 3 1 nan nan NNP cord-028034-pjotppso 3 2 DOI DOI NNP cord-028034-pjotppso 3 3 : : : cord-028034-pjotppso 3 4 10.1002 10.1002 CD cord-028034-pjotppso 3 5 / / SYM cord-028034-pjotppso 3 6 mco2.7 mco2.7 NN cord-028034-pjotppso 4 1 sha sha NNP cord-028034-pjotppso 4 2 : : : cord-028034-pjotppso 4 3 7ba2864cb445162644d5141e74665cdb3054b976 7ba2864cb445162644d5141e74665cdb3054b976 NNP cord-028034-pjotppso 4 4 doc_id doc_id NNP cord-028034-pjotppso 4 5 : : : cord-028034-pjotppso 4 6 28034 28034 CD cord-028034-pjotppso 5 1 cord_uid cord_uid NNS cord-028034-pjotppso 5 2 : : : cord-028034-pjotppso 5 3 pjotppso pjotppso NNP cord-028034-pjotppso 5 4 nan nan NNP cord-028034-pjotppso 6 1 The the DT cord-028034-pjotppso 6 2 coronavirus coronavirus NN cord-028034-pjotppso 6 3 disease disease NN cord-028034-pjotppso 6 4 2019 2019 CD cord-028034-pjotppso 6 5 ( ( -LRB- cord-028034-pjotppso 6 6 COVID-19 COVID-19 NNP cord-028034-pjotppso 6 7 ) ) -RRB- cord-028034-pjotppso 6 8 caused cause VBN cord-028034-pjotppso 6 9 by by IN cord-028034-pjotppso 6 10 severe severe JJ cord-028034-pjotppso 6 11 acute acute JJ cord-028034-pjotppso 6 12 respiratory respiratory JJ cord-028034-pjotppso 6 13 syndrome syndrome NN cord-028034-pjotppso 6 14 coronavirus coronavirus NN cord-028034-pjotppso 6 15 2 2 CD cord-028034-pjotppso 7 1 ( ( -LRB- cord-028034-pjotppso 7 2 SARS SARS NNP cord-028034-pjotppso 7 3 - - HYPH cord-028034-pjotppso 7 4 CoV-2 CoV-2 NNP cord-028034-pjotppso 7 5 ) ) -RRB- cord-028034-pjotppso 7 6 is be VBZ cord-028034-pjotppso 7 7 an an DT cord-028034-pjotppso 7 8 ongoing ongoing JJ cord-028034-pjotppso 7 9 pandemic pandemic NN cord-028034-pjotppso 7 10 . . . cord-028034-pjotppso 8 1 According accord VBG cord-028034-pjotppso 8 2 to to IN cord-028034-pjotppso 8 3 the the DT cord-028034-pjotppso 8 4 data datum NNS cord-028034-pjotppso 8 5 on on IN cord-028034-pjotppso 8 6 18 18 CD cord-028034-pjotppso 8 7 April April NNP cord-028034-pjotppso 8 8 2020 2020 CD cord-028034-pjotppso 8 9 , , , cord-028034-pjotppso 8 10 there there EX cord-028034-pjotppso 8 11 were be VBD cord-028034-pjotppso 8 12 more more JJR cord-028034-pjotppso 8 13 than than IN cord-028034-pjotppso 8 14 2 2 CD cord-028034-pjotppso 8 15 million million CD cord-028034-pjotppso 8 16 people people NNS cord-028034-pjotppso 8 17 infected infect VBN cord-028034-pjotppso 8 18 by by IN cord-028034-pjotppso 8 19 SARS SARS NNP cord-028034-pjotppso 8 20 - - HYPH cord-028034-pjotppso 8 21 CoV-2 CoV-2 NNP cord-028034-pjotppso 8 22 in in IN cord-028034-pjotppso 8 23 211 211 CD cord-028034-pjotppso 8 24 countries country NNS cord-028034-pjotppso 8 25 and and CC cord-028034-pjotppso 8 26 regions region NNS cord-028034-pjotppso 8 27 , , , cord-028034-pjotppso 8 28 and and CC cord-028034-pjotppso 9 1 the the DT cord-028034-pjotppso 9 2 mortality mortality NN cord-028034-pjotppso 9 3 rate rate NN cord-028034-pjotppso 9 4 of of IN cord-028034-pjotppso 9 5 COVID-19 COVID-19 NNP cord-028034-pjotppso 9 6 is be VBZ cord-028034-pjotppso 9 7 about about RB cord-028034-pjotppso 9 8 6.95 6.95 CD cord-028034-pjotppso 9 9 % % NN cord-028034-pjotppso 9 10 ( ( -LRB- cord-028034-pjotppso 9 11 153 153 CD cord-028034-pjotppso 9 12 406 406 CD cord-028034-pjotppso 9 13 deaths death NNS cord-028034-pjotppso 9 14 out out IN cord-028034-pjotppso 9 15 of of IN cord-028034-pjotppso 9 16 2 2 CD cord-028034-pjotppso 9 17 205 205 CD cord-028034-pjotppso 9 18 733 733 CD cord-028034-pjotppso 9 19 cases case NNS cord-028034-pjotppso 9 20 ) ) -RRB- cord-028034-pjotppso 9 21 . . . cord-028034-pjotppso 10 1 Two two CD cord-028034-pjotppso 10 2 recent recent JJ cord-028034-pjotppso 10 3 clinical clinical JJ cord-028034-pjotppso 10 4 summaries summary NNS cord-028034-pjotppso 10 5 of of IN cord-028034-pjotppso 10 6 patients patient NNS cord-028034-pjotppso 10 7 with with IN cord-028034-pjotppso 10 8 COVID-19 COVID-19 NNP cord-028034-pjotppso 10 9 reported report VBD cord-028034-pjotppso 10 10 that that IN cord-028034-pjotppso 10 11 cytokine cytokine NN cord-028034-pjotppso 10 12 storm storm NN cord-028034-pjotppso 10 13 was be VBD cord-028034-pjotppso 10 14 associated associate VBN cord-028034-pjotppso 10 15 with with IN cord-028034-pjotppso 10 16 the the DT cord-028034-pjotppso 10 17 severity severity NN cord-028034-pjotppso 10 18 and and CC cord-028034-pjotppso 10 19 death death NN cord-028034-pjotppso 10 20 of of IN cord-028034-pjotppso 10 21 patients patient NNS cord-028034-pjotppso 10 22 with with IN cord-028034-pjotppso 10 23 COVID-19 COVID-19 NNP cord-028034-pjotppso 10 24 . . NNP cord-028034-pjotppso 10 25 1 1 CD cord-028034-pjotppso 10 26 , , , cord-028034-pjotppso 10 27 2 2 CD cord-028034-pjotppso 10 28 Consequently consequently RB cord-028034-pjotppso 10 29 , , , cord-028034-pjotppso 10 30 it -PRON- PRP cord-028034-pjotppso 10 31 was be VBD cord-028034-pjotppso 10 32 urgent urgent JJ cord-028034-pjotppso 10 33 to to TO cord-028034-pjotppso 10 34 seek seek VB cord-028034-pjotppso 10 35 effective effective JJ cord-028034-pjotppso 10 36 prevention prevention NN cord-028034-pjotppso 10 37 and and CC cord-028034-pjotppso 10 38 treatments treatment NNS cord-028034-pjotppso 10 39 for for IN cord-028034-pjotppso 10 40 the the DT cord-028034-pjotppso 10 41 cytokine cytokine NN cord-028034-pjotppso 10 42 storm storm NN cord-028034-pjotppso 10 43 in in IN cord-028034-pjotppso 10 44 COVID-19 covid-19 JJ cord-028034-pjotppso 10 45 patients patient NNS cord-028034-pjotppso 10 46 , , , cord-028034-pjotppso 10 47 especially especially RB cord-028034-pjotppso 10 48 those those DT cord-028034-pjotppso 10 49 under under IN cord-028034-pjotppso 10 50 intensive intensive JJ cord-028034-pjotppso 10 51 care care NN cord-028034-pjotppso 10 52 unit unit NN cord-028034-pjotppso 10 53 ( ( -LRB- cord-028034-pjotppso 10 54 ICU ICU NNP cord-028034-pjotppso 10 55 ) ) -RRB- cord-028034-pjotppso 10 56 . . . cord-028034-pjotppso 11 1 The the DT cord-028034-pjotppso 11 2 clinical clinical JJ cord-028034-pjotppso 11 3 features feature NNS cord-028034-pjotppso 11 4 of of IN cord-028034-pjotppso 11 5 138 138 CD cord-028034-pjotppso 11 6 patients patient NNS cord-028034-pjotppso 11 7 with with IN cord-028034-pjotppso 11 8 COVID-19 COVID-19 NNP cord-028034-pjotppso 11 9 revealed reveal VBD cord-028034-pjotppso 11 10 that that IN cord-028034-pjotppso 11 11 the the DT cord-028034-pjotppso 11 12 number number NN cord-028034-pjotppso 11 13 of of IN cord-028034-pjotppso 11 14 lymphocytes lymphocyte NNS cord-028034-pjotppso 11 15 decreased decrease VBD cord-028034-pjotppso 11 16 , , , cord-028034-pjotppso 11 17 the the DT cord-028034-pjotppso 11 18 number number NN cord-028034-pjotppso 11 19 of of IN cord-028034-pjotppso 11 20 monocytes monocyte NNS cord-028034-pjotppso 11 21 unchanged unchanged JJ cord-028034-pjotppso 11 22 , , , cord-028034-pjotppso 11 23 and and CC cord-028034-pjotppso 11 24 the the DT cord-028034-pjotppso 11 25 number number NN cord-028034-pjotppso 11 26 of of IN cord-028034-pjotppso 11 27 neutrophil neutrophil NN cord-028034-pjotppso 11 28 significantly significantly RB cord-028034-pjotppso 11 29 increased increase VBN cord-028034-pjotppso 11 30 , , , cord-028034-pjotppso 11 31 which which WDT cord-028034-pjotppso 11 32 might may MD cord-028034-pjotppso 11 33 account account VB cord-028034-pjotppso 11 34 for for IN cord-028034-pjotppso 11 35 the the DT cord-028034-pjotppso 11 36 cytokine cytokine NN cord-028034-pjotppso 11 37 storm storm NN cord-028034-pjotppso 11 38 . . . cord-028034-pjotppso 12 1 2 2 LS cord-028034-pjotppso 13 1 In in IN cord-028034-pjotppso 13 2 addition addition NN cord-028034-pjotppso 13 3 , , , cord-028034-pjotppso 13 4 Guan Guan NNP cord-028034-pjotppso 13 5 et et NNP cord-028034-pjotppso 13 6 al al NNP cord-028034-pjotppso 13 7 reported report VBD cord-028034-pjotppso 13 8 that that IN cord-028034-pjotppso 13 9 lymphocytopenia lymphocytopenia NNP cord-028034-pjotppso 13 10 was be VBD cord-028034-pjotppso 13 11 present present JJ cord-028034-pjotppso 13 12 in in IN cord-028034-pjotppso 13 13 83.2 83.2 CD cord-028034-pjotppso 13 14 % % NN cord-028034-pjotppso 13 15 of of IN cord-028034-pjotppso 13 16 1099 1099 CD cord-028034-pjotppso 13 17 patients patient NNS cord-028034-pjotppso 13 18 with with IN cord-028034-pjotppso 13 19 COVID-19 covid-19 CD cord-028034-pjotppso 13 20 from from IN cord-028034-pjotppso 13 21 552 552 CD cord-028034-pjotppso 13 22 hospitals hospital NNS cord-028034-pjotppso 13 23 in in IN cord-028034-pjotppso 13 24 China China NNP cord-028034-pjotppso 13 25 . . . cord-028034-pjotppso 14 1 3 3 LS cord-028034-pjotppso 15 1 Tan Tan NNP cord-028034-pjotppso 15 2 et et FW cord-028034-pjotppso 15 3 al al NNP cord-028034-pjotppso 15 4 also also RB cord-028034-pjotppso 15 5 reported report VBD cord-028034-pjotppso 15 6 that that IN cord-028034-pjotppso 15 7 lymphopenia lymphopenia NNP cord-028034-pjotppso 15 8 predicted predict VBD cord-028034-pjotppso 15 9 the the DT cord-028034-pjotppso 15 10 severity severity NN cord-028034-pjotppso 15 11 of of IN cord-028034-pjotppso 15 12 COVID-19 COVID-19 NNP cord-028034-pjotppso 15 13 . . . cord-028034-pjotppso 16 1 4 4 LS cord-028034-pjotppso 16 2 Overall overall RB cord-028034-pjotppso 16 3 , , , cord-028034-pjotppso 16 4 these these DT cord-028034-pjotppso 16 5 reports report NNS cord-028034-pjotppso 16 6 suggested suggest VBD cord-028034-pjotppso 16 7 that that IN cord-028034-pjotppso 16 8 neutrophils neutrophil NNS cord-028034-pjotppso 16 9 rather rather RB cord-028034-pjotppso 16 10 than than IN cord-028034-pjotppso 16 11 lymphocytes lymphocyte NNS cord-028034-pjotppso 16 12 might may MD cord-028034-pjotppso 16 13 result result VB cord-028034-pjotppso 16 14 in in IN cord-028034-pjotppso 16 15 cytokine cytokine NN cord-028034-pjotppso 16 16 storm storm NN cord-028034-pjotppso 16 17 . . . cord-028034-pjotppso 17 1 [ [ -LRB- cord-028034-pjotppso 17 2 1 1 CD cord-028034-pjotppso 17 3 ] ] -RRB- cord-028034-pjotppso 17 4 [ [ -LRB- cord-028034-pjotppso 17 5 2 2 CD cord-028034-pjotppso 17 6 ] ] -RRB- cord-028034-pjotppso 17 7 [ [ -LRB- cord-028034-pjotppso 17 8 3 3 CD cord-028034-pjotppso 17 9 ] ] -RRB- cord-028034-pjotppso 17 10 [ [ -LRB- cord-028034-pjotppso 17 11 4 4 CD cord-028034-pjotppso 17 12 ] ] -RRB- cord-028034-pjotppso 18 1 Normally normally RB cord-028034-pjotppso 18 2 , , , cord-028034-pjotppso 18 3 neutrophil neutrophil NN cord-028034-pjotppso 18 4 underwent undergo VBD cord-028034-pjotppso 18 5 apoptosis apoptosis NN cord-028034-pjotppso 18 6 after after IN cord-028034-pjotppso 18 7 its -PRON- PRP$ cord-028034-pjotppso 18 8 activation activation NN cord-028034-pjotppso 18 9 . . . cord-028034-pjotppso 19 1 5 5 LS cord-028034-pjotppso 20 1 The the DT cord-028034-pjotppso 20 2 failure failure NN cord-028034-pjotppso 20 3 of of IN cord-028034-pjotppso 20 4 neutrophil neutrophil NN cord-028034-pjotppso 20 5 apoptosis apoptosis NN cord-028034-pjotppso 20 6 might may MD cord-028034-pjotppso 20 7 lead lead VB cord-028034-pjotppso 20 8 to to IN cord-028034-pjotppso 20 9 the the DT cord-028034-pjotppso 20 10 accumulation accumulation NN cord-028034-pjotppso 20 11 of of IN cord-028034-pjotppso 20 12 neutrophil neutrophil NN cord-028034-pjotppso 20 13 and and CC cord-028034-pjotppso 20 14 increase increase VB cord-028034-pjotppso 20 15 the the DT cord-028034-pjotppso 20 16 chance chance NN cord-028034-pjotppso 20 17 of of IN cord-028034-pjotppso 20 18 necrosis necrosis NN cord-028034-pjotppso 20 19 , , , cord-028034-pjotppso 20 20 which which WDT cord-028034-pjotppso 20 21 could could MD cord-028034-pjotppso 20 22 release release VB cord-028034-pjotppso 20 23 the the DT cord-028034-pjotppso 20 24 toxic toxic JJ cord-028034-pjotppso 20 25 intracellular intracellular JJ cord-028034-pjotppso 20 26 components component NNS cord-028034-pjotppso 20 27 and and CC cord-028034-pjotppso 20 28 overactivate overactivate VBP cord-028034-pjotppso 20 29 the the DT cord-028034-pjotppso 20 30 immune immune JJ cord-028034-pjotppso 20 31 system system NN cord-028034-pjotppso 20 32 . . . cord-028034-pjotppso 21 1 5 5 LS cord-028034-pjotppso 22 1 Interestingly interestingly RB cord-028034-pjotppso 22 2 , , , cord-028034-pjotppso 22 3 administration administration NN cord-028034-pjotppso 22 4 of of IN cord-028034-pjotppso 22 5 vitamin vitamin NN cord-028034-pjotppso 22 6 C C NNP cord-028034-pjotppso 22 7 ( ( -LRB- cord-028034-pjotppso 22 8 Vc Vc NNP cord-028034-pjotppso 22 9 ) ) -RRB- cord-028034-pjotppso 22 10 could could MD cord-028034-pjotppso 22 11 decrease decrease VB cord-028034-pjotppso 22 12 the the DT cord-028034-pjotppso 22 13 number number NN cord-028034-pjotppso 22 14 of of IN cord-028034-pjotppso 22 15 neutrophil neutrophil NN cord-028034-pjotppso 22 16 in in IN cord-028034-pjotppso 22 17 septic septic JJ cord-028034-pjotppso 22 18 animals animal NNS cord-028034-pjotppso 22 19 , , , cord-028034-pjotppso 22 20 and and CC cord-028034-pjotppso 22 21 Vc vc NN cord-028034-pjotppso 22 22 - - HYPH cord-028034-pjotppso 22 23 deficient deficient JJ cord-028034-pjotppso 22 24 neutrophils neutrophil NNS cord-028034-pjotppso 22 25 were be VBD cord-028034-pjotppso 22 26 not not RB cord-028034-pjotppso 22 27 efficiently efficiently RB cord-028034-pjotppso 22 28 removed remove VBN cord-028034-pjotppso 22 29 by by IN cord-028034-pjotppso 22 30 macrophages macrophage NNS cord-028034-pjotppso 22 31 . . . cord-028034-pjotppso 23 1 5 5 LS cord-028034-pjotppso 24 1 In in IN cord-028034-pjotppso 24 2 addition addition NN cord-028034-pjotppso 24 3 , , , cord-028034-pjotppso 24 4 because because IN cord-028034-pjotppso 24 5 the the DT cord-028034-pjotppso 24 6 caspase caspase NN cord-028034-pjotppso 24 7 - - HYPH cord-028034-pjotppso 24 8 dependent dependent JJ cord-028034-pjotppso 24 9 apoptosis apoptosis NN cord-028034-pjotppso 24 10 was be VBD cord-028034-pjotppso 24 11 oxidant oxidant JJ cord-028034-pjotppso 24 12 sensitive sensitive JJ cord-028034-pjotppso 24 13 , , , cord-028034-pjotppso 24 14 Vc Vc NNP cord-028034-pjotppso 24 15 was be VBD cord-028034-pjotppso 24 16 expected expect VBN cord-028034-pjotppso 24 17 to to TO cord-028034-pjotppso 24 18 escort escort VB cord-028034-pjotppso 24 19 the the DT cord-028034-pjotppso 24 20 apoptotic apoptotic JJ cord-028034-pjotppso 24 21 process process NN cord-028034-pjotppso 24 22 and and CC cord-028034-pjotppso 24 23 avoid avoid VB cord-028034-pjotppso 24 24 inflammatory inflammatory JJ cord-028034-pjotppso 24 25 necrosis necrosis NN cord-028034-pjotppso 24 26 following follow VBG cord-028034-pjotppso 24 27 the the DT cord-028034-pjotppso 24 28 activation activation NN cord-028034-pjotppso 24 29 of of IN cord-028034-pjotppso 24 30 neutrophil neutrophil NN cord-028034-pjotppso 24 31 . . . cord-028034-pjotppso 25 1 5 5 LS cord-028034-pjotppso 26 1 Moreover moreover RB cord-028034-pjotppso 26 2 , , , cord-028034-pjotppso 26 3 neutrophils neutrophil NNS cord-028034-pjotppso 26 4 need need VBP cord-028034-pjotppso 26 5 millimolar millimolar JJ cord-028034-pjotppso 26 6 concentrations concentration NNS cord-028034-pjotppso 26 7 of of IN cord-028034-pjotppso 26 8 intracellular intracellular JJ cord-028034-pjotppso 26 9 Vc Vc NNP cord-028034-pjotppso 26 10 for for IN cord-028034-pjotppso 26 11 their -PRON- PRP$ cord-028034-pjotppso 26 12 pathogen pathogen NN cord-028034-pjotppso 26 13 - - HYPH cord-028034-pjotppso 26 14 eradicating eradicate VBG cord-028034-pjotppso 26 15 functions function NNS cord-028034-pjotppso 26 16 and and CC cord-028034-pjotppso 26 17 motility motility NN cord-028034-pjotppso 26 18 . . . cord-028034-pjotppso 27 1 5 5 LS cord-028034-pjotppso 28 1 Consequently consequently RB cord-028034-pjotppso 28 2 , , , cord-028034-pjotppso 28 3 the the DT cord-028034-pjotppso 28 4 oral oral JJ cord-028034-pjotppso 28 5 administration administration NN cord-028034-pjotppso 28 6 of of IN cord-028034-pjotppso 28 7 sufficient sufficient JJ cord-028034-pjotppso 28 8 Vc Vc NNP cord-028034-pjotppso 28 9 might may MD cord-028034-pjotppso 28 10 be be VB cord-028034-pjotppso 28 11 sufficient sufficient JJ cord-028034-pjotppso 28 12 to to TO cord-028034-pjotppso 28 13 ameliorate ameliorate VB cord-028034-pjotppso 28 14 the the DT cord-028034-pjotppso 28 15 cytokine cytokine NN cord-028034-pjotppso 28 16 storm storm NN cord-028034-pjotppso 28 17 caused cause VBN cord-028034-pjotppso 28 18 by by IN cord-028034-pjotppso 28 19 neutrophils neutrophil NNS cord-028034-pjotppso 28 20 . . . cord-028034-pjotppso 29 1 Interestingly interestingly RB cord-028034-pjotppso 29 2 , , , cord-028034-pjotppso 29 3 a a DT cord-028034-pjotppso 29 4 clinical clinical JJ cord-028034-pjotppso 29 5 trial trial NN cord-028034-pjotppso 29 6 of of IN cord-028034-pjotppso 29 7 high high JJ cord-028034-pjotppso 29 8 - - HYPH cord-028034-pjotppso 29 9 dose dose NN cord-028034-pjotppso 29 10 Vc Vc NNP cord-028034-pjotppso 29 11 infusion infusion NN cord-028034-pjotppso 29 12 for for IN cord-028034-pjotppso 29 13 COVID-19 COVID-19 NNP cord-028034-pjotppso 29 14 This this DT cord-028034-pjotppso 29 15 is be VBZ cord-028034-pjotppso 29 16 an an DT cord-028034-pjotppso 29 17 open open JJ cord-028034-pjotppso 29 18 access access NN cord-028034-pjotppso 29 19 article article NN cord-028034-pjotppso 29 20 under under IN cord-028034-pjotppso 29 21 the the DT cord-028034-pjotppso 29 22 terms term NNS cord-028034-pjotppso 29 23 of of IN cord-028034-pjotppso 29 24 the the DT cord-028034-pjotppso 29 25 Creative Creative NNP cord-028034-pjotppso 29 26 Commons Commons NNP cord-028034-pjotppso 29 27 Attribution Attribution NNP cord-028034-pjotppso 29 28 License License NNP cord-028034-pjotppso 29 29 , , , cord-028034-pjotppso 29 30 which which WDT cord-028034-pjotppso 29 31 permits permit VBZ cord-028034-pjotppso 29 32 use use NN cord-028034-pjotppso 29 33 , , , cord-028034-pjotppso 29 34 distribution distribution NN cord-028034-pjotppso 29 35 and and CC cord-028034-pjotppso 29 36 reproduction reproduction NN cord-028034-pjotppso 29 37 in in IN cord-028034-pjotppso 29 38 any any DT cord-028034-pjotppso 29 39 medium medium NN cord-028034-pjotppso 29 40 , , , cord-028034-pjotppso 29 41 provided provide VBD cord-028034-pjotppso 29 42 the the DT cord-028034-pjotppso 29 43 original original JJ cord-028034-pjotppso 29 44 work work NN cord-028034-pjotppso 29 45 is be VBZ cord-028034-pjotppso 29 46 properly properly RB cord-028034-pjotppso 29 47 cited cite VBN cord-028034-pjotppso 29 48 . . . cord-028034-pjotppso 30 1 was be VBD cord-028034-pjotppso 30 2 registered register VBN cord-028034-pjotppso 31 1 ( ( -LRB- cord-028034-pjotppso 31 2 ClinicalTrials ClinicalTrials NNP cord-028034-pjotppso 31 3 : : : cord-028034-pjotppso 31 4 NCT04264533 NCT04264533 NNPS cord-028034-pjotppso 31 5 ) ) -RRB- cord-028034-pjotppso 31 6 on on IN cord-028034-pjotppso 31 7 11 11 CD cord-028034-pjotppso 31 8 February February NNP cord-028034-pjotppso 31 9 2020 2020 CD cord-028034-pjotppso 31 10 . . . cord-028034-pjotppso 32 1 Th17 Th17 NNP cord-028034-pjotppso 32 2 , , , cord-028034-pjotppso 32 3 an an DT cord-028034-pjotppso 32 4 interleukin-17 interleukin-17 NN cord-028034-pjotppso 32 5 ( ( -LRB- cord-028034-pjotppso 32 6 IL-17 IL-17 NNP cord-028034-pjotppso 32 7 ) ) -RRB- cord-028034-pjotppso 32 8 secreting secrete VBG cord-028034-pjotppso 32 9 CD4 CD4 NNP cord-028034-pjotppso 32 10 + + CC cord-028034-pjotppso 32 11 T t NN cord-028034-pjotppso 32 12 cell cell NN cord-028034-pjotppso 32 13 , , , cord-028034-pjotppso 32 14 has have VBZ cord-028034-pjotppso 32 15 a a DT cord-028034-pjotppso 32 16 unique unique JJ cord-028034-pjotppso 32 17 link link NN cord-028034-pjotppso 32 18 to to TO cord-028034-pjotppso 32 19 augment augment VB cord-028034-pjotppso 32 20 and and CC cord-028034-pjotppso 32 21 coordinate coordinate VB cord-028034-pjotppso 32 22 the the DT cord-028034-pjotppso 32 23 functions function NNS cord-028034-pjotppso 32 24 of of IN cord-028034-pjotppso 32 25 neutrophils neutrophil NNS cord-028034-pjotppso 32 26 . . . cord-028034-pjotppso 33 1 6 6 CD cord-028034-pjotppso 33 2 Th17 th17 NN cord-028034-pjotppso 33 3 was be VBD cord-028034-pjotppso 33 4 significantly significantly RB cord-028034-pjotppso 33 5 increased increase VBN cord-028034-pjotppso 33 6 in in IN cord-028034-pjotppso 33 7 the the DT cord-028034-pjotppso 33 8 ICU ICU NNP cord-028034-pjotppso 33 9 patients patient NNS cord-028034-pjotppso 33 10 with with IN cord-028034-pjotppso 33 11 COVID-19 COVID-19 NNP cord-028034-pjotppso 33 12 . . . cord-028034-pjotppso 34 1 1 1 LS cord-028034-pjotppso 34 2 IL-6 IL-6 NNP cord-028034-pjotppso 34 3 is be VBZ cord-028034-pjotppso 34 4 one one CD cord-028034-pjotppso 34 5 of of IN cord-028034-pjotppso 34 6 critical critical JJ cord-028034-pjotppso 34 7 factors factor NNS cord-028034-pjotppso 34 8 for for IN cord-028034-pjotppso 34 9 the the DT cord-028034-pjotppso 34 10 differentiation differentiation NN cord-028034-pjotppso 34 11 and and CC cord-028034-pjotppso 34 12 development development NN cord-028034-pjotppso 34 13 of of IN cord-028034-pjotppso 34 14 Th17 Th17 NNP cord-028034-pjotppso 34 15 cell cell NN cord-028034-pjotppso 34 16 . . . cord-028034-pjotppso 35 1 6 6 CD cord-028034-pjotppso 36 1 Tocilizumab Tocilizumab NNP cord-028034-pjotppso 36 2 could could MD cord-028034-pjotppso 36 3 bind bind VB cord-028034-pjotppso 36 4 and and CC cord-028034-pjotppso 36 5 block block VB cord-028034-pjotppso 36 6 the the DT cord-028034-pjotppso 36 7 effects effect NNS cord-028034-pjotppso 36 8 of of IN cord-028034-pjotppso 36 9 IL-6 IL-6 NNP cord-028034-pjotppso 36 10 and and CC cord-028034-pjotppso 36 11 might may MD cord-028034-pjotppso 36 12 have have VB cord-028034-pjotppso 36 13 a a DT cord-028034-pjotppso 36 14 potential potential JJ cord-028034-pjotppso 36 15 effect effect NN cord-028034-pjotppso 36 16 for for IN cord-028034-pjotppso 36 17 COVID-19 COVID-19 NNP cord-028034-pjotppso 36 18 treatment treatment NN cord-028034-pjotppso 36 19 , , , cord-028034-pjotppso 36 20 so so IN cord-028034-pjotppso 36 21 that that IN cord-028034-pjotppso 36 22 a a DT cord-028034-pjotppso 36 23 clinical clinical JJ cord-028034-pjotppso 36 24 trial trial NN cord-028034-pjotppso 36 25 was be VBD cord-028034-pjotppso 36 26 also also RB cord-028034-pjotppso 36 27 registered register VBN cord-028034-pjotppso 36 28 ( ( -LRB- cord-028034-pjotppso 36 29 ChiCTR2000029765 ChiCTR2000029765 VBN cord-028034-pjotppso 36 30 ) ) -RRB- cord-028034-pjotppso 36 31 on on IN cord-028034-pjotppso 36 32 13 13 CD cord-028034-pjotppso 36 33 February February NNP cord-028034-pjotppso 36 34 2020 2020 CD cord-028034-pjotppso 36 35 . . . cord-028034-pjotppso 37 1 Importantly importantly RB cord-028034-pjotppso 37 2 , , , cord-028034-pjotppso 37 3 1 1 CD cord-028034-pjotppso 37 4 - - SYM cord-028034-pjotppso 37 5 10 10 CD cord-028034-pjotppso 37 6 nM nm CD cord-028034-pjotppso 37 7 of of IN cord-028034-pjotppso 37 8 vitamin vitamin NN cord-028034-pjotppso 37 9 D d NN cord-028034-pjotppso 37 10 ( ( -LRB- cord-028034-pjotppso 37 11 Vd Vd NNP cord-028034-pjotppso 37 12 ) ) -RRB- cord-028034-pjotppso 37 13 via via IN cord-028034-pjotppso 37 14 vitamin vitamin NN cord-028034-pjotppso 37 15 D d NN cord-028034-pjotppso 37 16 receptor receptor NN cord-028034-pjotppso 37 17 ( ( -LRB- cord-028034-pjotppso 37 18 VDR VDR NNP cord-028034-pjotppso 37 19 ) ) -RRB- cord-028034-pjotppso 37 20 could could MD cord-028034-pjotppso 37 21 efficiently efficiently RB cord-028034-pjotppso 37 22 suppress suppress VB cord-028034-pjotppso 37 23 the the DT cord-028034-pjotppso 37 24 cytokine cytokine NN cord-028034-pjotppso 37 25 production production NN cord-028034-pjotppso 37 26 of of IN cord-028034-pjotppso 37 27 Th17 Th17 NNP cord-028034-pjotppso 37 28 by by IN cord-028034-pjotppso 37 29 inducing induce VBG cord-028034-pjotppso 37 30 the the DT cord-028034-pjotppso 37 31 expression expression NN cord-028034-pjotppso 37 32 of of IN cord-028034-pjotppso 37 33 C C NNP cord-028034-pjotppso 37 34 / / SYM cord-028034-pjotppso 37 35 EBP ebp NN cord-028034-pjotppso 37 36 homologous homologous JJ cord-028034-pjotppso 37 37 protein protein NN cord-028034-pjotppso 37 38 ( ( -LRB- cord-028034-pjotppso 37 39 CHOP CHOP NNP cord-028034-pjotppso 37 40 ) ) -RRB- cord-028034-pjotppso 37 41 . . . cord-028034-pjotppso 38 1 7 7 CD cord-028034-pjotppso 39 1 Together together RB cord-028034-pjotppso 39 2 , , , cord-028034-pjotppso 39 3 the the DT cord-028034-pjotppso 39 4 simultaneous simultaneous JJ cord-028034-pjotppso 39 5 administration administration NN cord-028034-pjotppso 39 6 of of IN cord-028034-pjotppso 39 7 sufficient sufficient JJ cord-028034-pjotppso 39 8 Vc Vc NNP cord-028034-pjotppso 39 9 and and CC cord-028034-pjotppso 39 10 Vd Vd NNP cord-028034-pjotppso 39 11 might may MD cord-028034-pjotppso 39 12 ameliorate ameliorate VB cord-028034-pjotppso 39 13 the the DT cord-028034-pjotppso 39 14 neutrophil neutrophil NN cord-028034-pjotppso 39 15 - - HYPH cord-028034-pjotppso 39 16 related relate VBN cord-028034-pjotppso 39 17 cytokine cytokine NN cord-028034-pjotppso 39 18 storm storm NN cord-028034-pjotppso 39 19 in in IN cord-028034-pjotppso 39 20 the the DT cord-028034-pjotppso 39 21 patients patient NNS cord-028034-pjotppso 39 22 with with IN cord-028034-pjotppso 39 23 COVID-19 COVID-19 NNP cord-028034-pjotppso 39 24 , , , cord-028034-pjotppso 39 25 especially especially RB cord-028034-pjotppso 39 26 those those DT cord-028034-pjotppso 39 27 under under IN cord-028034-pjotppso 39 28 ICU ICU NNP cord-028034-pjotppso 39 29 ( ( -LRB- cord-028034-pjotppso 39 30 Figure figure NN cord-028034-pjotppso 39 31 1 1 CD cord-028034-pjotppso 39 32 ) ) -RRB- cord-028034-pjotppso 39 33 . . . cord-028034-pjotppso 40 1 Recommended recommend VBN cord-028034-pjotppso 40 2 dietary dietary JJ cord-028034-pjotppso 40 3 allowances allowance NNS cord-028034-pjotppso 40 4 ( ( -LRB- cord-028034-pjotppso 40 5 RDAs rda NNS cord-028034-pjotppso 40 6 ) ) -RRB- cord-028034-pjotppso 40 7 for for IN cord-028034-pjotppso 40 8 Vd Vd NNP cord-028034-pjotppso 40 9 are be VBP cord-028034-pjotppso 40 10 as as IN cord-028034-pjotppso 40 11 follows follow VBZ cord-028034-pjotppso 40 12 : : : cord-028034-pjotppso 41 1 800 800 CD cord-028034-pjotppso 41 2 IU IU NNP cord-028034-pjotppso 41 3 for for IN cord-028034-pjotppso 41 4 a a DT cord-028034-pjotppso 41 5 level level NN cord-028034-pjotppso 41 6 of of IN cord-028034-pjotppso 41 7 20 20 CD cord-028034-pjotppso 41 8 ng ng NN cord-028034-pjotppso 41 9 / / SYM cord-028034-pjotppso 41 10 mL ml NN cord-028034-pjotppso 41 11 ( ( -LRB- cord-028034-pjotppso 41 12 50 50 CD cord-028034-pjotppso 41 13 nM nm NN cord-028034-pjotppso 41 14 ) ) -RRB- cord-028034-pjotppso 41 15 and and CC cord-028034-pjotppso 41 16 1600 1600 CD cord-028034-pjotppso 41 17 IU IU NNP cord-028034-pjotppso 41 18 for for IN cord-028034-pjotppso 41 19 a a DT cord-028034-pjotppso 41 20 level level NN cord-028034-pjotppso 41 21 of of IN cord-028034-pjotppso 41 22 30 30 CD cord-028034-pjotppso 41 23 ng ng NN cord-028034-pjotppso 41 24 / / SYM cord-028034-pjotppso 41 25 mL ml NN cord-028034-pjotppso 41 26 ( ( -LRB- cord-028034-pjotppso 41 27 75 75 CD cord-028034-pjotppso 41 28 nM nm NN cord-028034-pjotppso 41 29 ) ) -RRB- cord-028034-pjotppso 41 30 . . . cord-028034-pjotppso 42 1 8 8 CD cord-028034-pjotppso 43 1 These these DT cord-028034-pjotppso 43 2 nanomolar nanomolar JJ cord-028034-pjotppso 43 3 concentrations concentration NNS cord-028034-pjotppso 43 4 of of IN cord-028034-pjotppso 43 5 Vd Vd NNP cord-028034-pjotppso 43 6 should should MD cord-028034-pjotppso 43 7 sufficiently sufficiently RB cord-028034-pjotppso 43 8 induce induce VB cord-028034-pjotppso 43 9 CHOP chop NN cord-028034-pjotppso 43 10 expression expression NN cord-028034-pjotppso 43 11 via via IN cord-028034-pjotppso 43 12 VDR VDR NNP cord-028034-pjotppso 43 13 to to TO cord-028034-pjotppso 43 14 inhibit inhibit VB cord-028034-pjotppso 43 15 the the DT cord-028034-pjotppso 43 16 cytokine cytokine NN cord-028034-pjotppso 43 17 production production NN cord-028034-pjotppso 43 18 of of IN cord-028034-pjotppso 43 19 Th17 Th17 NNP cord-028034-pjotppso 44 1 and and CC cord-028034-pjotppso 44 2 the the DT cord-028034-pjotppso 44 3 Th17-related Th17-related NNP cord-028034-pjotppso 44 4 augmentation augmentation NN cord-028034-pjotppso 44 5 of of IN cord-028034-pjotppso 44 6 neutrophils neutrophil NNS cord-028034-pjotppso 44 7 . . . cord-028034-pjotppso 45 1 7 7 CD cord-028034-pjotppso 46 1 Based base VBN cord-028034-pjotppso 46 2 on on IN cord-028034-pjotppso 46 3 the the DT cord-028034-pjotppso 46 4 many many JJ cord-028034-pjotppso 46 5 mechanisms mechanism NNS cord-028034-pjotppso 46 6 of of IN cord-028034-pjotppso 46 7 Vd Vd NNP cord-028034-pjotppso 46 8 reducing reduce VBG cord-028034-pjotppso 46 9 the the DT cord-028034-pjotppso 46 10 risk risk NN cord-028034-pjotppso 46 11 of of IN cord-028034-pjotppso 46 12 viral viral JJ cord-028034-pjotppso 46 13 infections infection NNS cord-028034-pjotppso 46 14 , , , cord-028034-pjotppso 46 15 Grant Grant NNP cord-028034-pjotppso 46 16 et et NNP cord-028034-pjotppso 46 17 al al NNP cord-028034-pjotppso 46 18 recommended recommend VBD cord-028034-pjotppso 46 19 that that IN cord-028034-pjotppso 46 20 a a DT cord-028034-pjotppso 46 21 daily daily JJ cord-028034-pjotppso 46 22 dose dose NN cord-028034-pjotppso 46 23 ( ( -LRB- cord-028034-pjotppso 46 24 10 10 CD cord-028034-pjotppso 46 25 000 000 CD cord-028034-pjotppso 46 26 IU IU NNP cord-028034-pjotppso 46 27 ) ) -RRB- cord-028034-pjotppso 46 28 of of IN cord-028034-pjotppso 46 29 Vd Vd NNP cord-028034-pjotppso 46 30 should should MD cord-028034-pjotppso 46 31 be be VB cord-028034-pjotppso 46 32 taken take VBN cord-028034-pjotppso 46 33 to to TO cord-028034-pjotppso 46 34 achieve achieve VB cord-028034-pjotppso 46 35 an an DT cord-028034-pjotppso 46 36 optimal optimal JJ cord-028034-pjotppso 46 37 level level NN cord-028034-pjotppso 46 38 of of IN cord-028034-pjotppso 46 39 40 40 CD cord-028034-pjotppso 46 40 - - SYM cord-028034-pjotppso 46 41 60 60 CD cord-028034-pjotppso 46 42 ng ng NN cord-028034-pjotppso 46 43 / / SYM cord-028034-pjotppso 46 44 mL ml NN cord-028034-pjotppso 46 45 ( ( -LRB- cord-028034-pjotppso 46 46 100 100 CD cord-028034-pjotppso 46 47 - - SYM cord-028034-pjotppso 46 48 150 150 CD cord-028034-pjotppso 46 49 nM nM NNP cord-028034-pjotppso 46 50 ) ) -RRB- cord-028034-pjotppso 46 51 , , , cord-028034-pjotppso 46 52 and and CC cord-028034-pjotppso 46 53 claimed claim VBD cord-028034-pjotppso 46 54 without without IN cord-028034-pjotppso 46 55 adverse adverse JJ cord-028034-pjotppso 46 56 effects effect NNS cord-028034-pjotppso 46 57 . . . cord-028034-pjotppso 47 1 9 9 CD cord-028034-pjotppso 48 1 However however RB cord-028034-pjotppso 48 2 , , , cord-028034-pjotppso 48 3 a a DT cord-028034-pjotppso 48 4 recent recent JJ cord-028034-pjotppso 48 5 preprint preprint NN cord-028034-pjotppso 48 6 of of IN cord-028034-pjotppso 48 7 medRxiv medRxiv NNS cord-028034-pjotppso 48 8 about about IN cord-028034-pjotppso 48 9 Vd Vd NNP cord-028034-pjotppso 48 10 suppressing suppress VBG cord-028034-pjotppso 48 11 cytokine cytokine JJ cord-028034-pjotppso 48 12 storm storm NN cord-028034-pjotppso 48 13 in in IN cord-028034-pjotppso 49 1 COVID-19 covid-19 JJ cord-028034-pjotppso 49 2 patients patient NNS cord-028034-pjotppso 49 3 was be VBD cord-028034-pjotppso 49 4 withdrawn withdraw VBN cord-028034-pjotppso 49 5 by by IN cord-028034-pjotppso 49 6 the the DT cord-028034-pjotppso 49 7 authors author NNS cord-028034-pjotppso 49 8 because because IN cord-028034-pjotppso 49 9 they -PRON- PRP cord-028034-pjotppso 49 10 noticed notice VBD cord-028034-pjotppso 49 11 the the DT cord-028034-pjotppso 49 12 idiosyncrasy idiosyncrasy NN cord-028034-pjotppso 49 13 of of IN cord-028034-pjotppso 49 14 Vd Vd NNP cord-028034-pjotppso 49 15 across across IN cord-028034-pjotppso 49 16 different different JJ cord-028034-pjotppso 49 17 countries country NNS cord-028034-pjotppso 49 18 . . . cord-028034-pjotppso 50 1 10 10 CD cord-028034-pjotppso 51 1 In in IN cord-028034-pjotppso 51 2 general general JJ cord-028034-pjotppso 51 3 , , , cord-028034-pjotppso 51 4 as as IN cord-028034-pjotppso 51 5 for for IN cord-028034-pjotppso 51 6 the the DT cord-028034-pjotppso 51 7 prevention prevention NN cord-028034-pjotppso 51 8 or or CC cord-028034-pjotppso 51 9 treatments treatment NNS cord-028034-pjotppso 51 10 of of IN cord-028034-pjotppso 51 11 the the DT cord-028034-pjotppso 51 12 neutrophil neutrophil NN cord-028034-pjotppso 51 13 - - HYPH cord-028034-pjotppso 51 14 related relate VBN cord-028034-pjotppso 51 15 cytokine cytokine NN cord-028034-pjotppso 51 16 storm storm NN cord-028034-pjotppso 51 17 , , , cord-028034-pjotppso 51 18 to to TO cord-028034-pjotppso 51 19 meet meet VB cord-028034-pjotppso 51 20 the the DT cord-028034-pjotppso 51 21 requirements requirement NNS cord-028034-pjotppso 51 22 of of IN cord-028034-pjotppso 51 23 50 50 CD cord-028034-pjotppso 51 24 % % NN cord-028034-pjotppso 51 25 of of IN cord-028034-pjotppso 51 26 the the DT cord-028034-pjotppso 51 27 population population NN cord-028034-pjotppso 51 28 , , , cord-028034-pjotppso 51 29 a a DT cord-028034-pjotppso 51 30 400 400 CD cord-028034-pjotppso 51 31 - - SYM cord-028034-pjotppso 51 32 600 600 CD cord-028034-pjotppso 51 33 IU IU NNP cord-028034-pjotppso 51 34 daily daily JJ cord-028034-pjotppso 51 35 dose dose NN cord-028034-pjotppso 51 36 of of IN cord-028034-pjotppso 51 37 Vd Vd NNP cord-028034-pjotppso 51 38 should should MD cord-028034-pjotppso 51 39 be be VB cord-028034-pjotppso 51 40 safe safe JJ cord-028034-pjotppso 51 41 and and CC cord-028034-pjotppso 51 42 sufficient sufficient JJ cord-028034-pjotppso 51 43 , , , cord-028034-pjotppso 51 44 whereas whereas IN cord-028034-pjotppso 51 45 the the DT cord-028034-pjotppso 51 46 RDA RDA NNP cord-028034-pjotppso 51 47 of of IN cord-028034-pjotppso 51 48 Vd Vd NNP cord-028034-pjotppso 51 49 ( ( -LRB- cord-028034-pjotppso 51 50 800 800 CD cord-028034-pjotppso 51 51 - - CD cord-028034-pjotppso 51 52 1600 1600 CD cord-028034-pjotppso 51 53 IU IU NNP cord-028034-pjotppso 51 54 daily daily RB cord-028034-pjotppso 51 55 ) ) -RRB- cord-028034-pjotppso 51 56 could could MD cord-028034-pjotppso 51 57 meet meet VB cord-028034-pjotppso 51 58 the the DT cord-028034-pjotppso 51 59 needs need NNS cord-028034-pjotppso 51 60 of of IN cord-028034-pjotppso 51 61 97.5 97.5 CD cord-028034-pjotppso 51 62 % % NN cord-028034-pjotppso 51 63 of of IN cord-028034-pjotppso 51 64 individuals individual NNS cord-028034-pjotppso 51 65 . . . cord-028034-pjotppso 52 1 8 8 CD cord-028034-pjotppso 53 1 Considering consider VBG cord-028034-pjotppso 53 2 that that IN cord-028034-pjotppso 53 3 Vc Vc NNP cord-028034-pjotppso 53 4 could could MD cord-028034-pjotppso 53 5 hinder hinder VB cord-028034-pjotppso 53 6 the the DT cord-028034-pjotppso 53 7 function function NN cord-028034-pjotppso 53 8 of of IN cord-028034-pjotppso 53 9 interferon interferon NN cord-028034-pjotppso 53 10 - - HYPH cord-028034-pjotppso 53 11 gamma gamma NN cord-028034-pjotppso 53 12 11 11 CD cord-028034-pjotppso 53 13 and and CC cord-028034-pjotppso 53 14 that that DT cord-028034-pjotppso 53 15 leukocytes leukocyte NNS cord-028034-pjotppso 53 16 including include VBG cord-028034-pjotppso 53 17 neutrophils neutrophil NNS cord-028034-pjotppso 53 18 and and CC cord-028034-pjotppso 53 19 monocytes monocyte NNS cord-028034-pjotppso 53 20 accumulate accumulate VBP cord-028034-pjotppso 53 21 maximal maximal JJ cord-028034-pjotppso 53 22 Vc Vc NNP cord-028034-pjotppso 53 23 concentrations concentration NNS cord-028034-pjotppso 53 24 at at IN cord-028034-pjotppso 53 25 MedComm MedComm NNP cord-028034-pjotppso 53 26 . . . cord-028034-pjotppso 54 1 2020;1:81 2020;1:81 CD cord-028034-pjotppso 54 2 - - SYM cord-028034-pjotppso 54 3 83 83 CD cord-028034-pjotppso 54 4 . . . cord-028034-pjotppso 55 1 wileyonlinelibrary.com/journal/mco2 wileyonlinelibrary.com/journal/mco2 JJ cord-028034-pjotppso 56 1 81 81 CD cord-028034-pjotppso 57 1 F F NNP cord-028034-pjotppso 57 2 I i NN cord-028034-pjotppso 57 3 G g NN cord-028034-pjotppso 58 1 U u NN cord-028034-pjotppso 58 2 R r NN cord-028034-pjotppso 58 3 E e NN cord-028034-pjotppso 58 4 1 1 CD cord-028034-pjotppso 58 5 Vitamin vitamin NN cord-028034-pjotppso 58 6 Intervention intervention NN cord-028034-pjotppso 58 7 for for IN cord-028034-pjotppso 58 8 neutrophil neutrophil NN cord-028034-pjotppso 58 9 - - HYPH cord-028034-pjotppso 58 10 related relate VBN cord-028034-pjotppso 58 11 cytokine cytokine NN cord-028034-pjotppso 58 12 storm storm NN cord-028034-pjotppso 58 13 . . . cord-028034-pjotppso 59 1 Neutrophil Neutrophil NNP cord-028034-pjotppso 59 2 - - HYPH cord-028034-pjotppso 59 3 related relate VBN cord-028034-pjotppso 59 4 cytokine cytokine NN cord-028034-pjotppso 59 5 storm storm NN cord-028034-pjotppso 59 6 was be VBD cord-028034-pjotppso 59 7 reported report VBN cord-028034-pjotppso 59 8 to to TO cord-028034-pjotppso 59 9 be be VB cord-028034-pjotppso 59 10 associated associate VBN cord-028034-pjotppso 59 11 with with IN cord-028034-pjotppso 59 12 the the DT cord-028034-pjotppso 59 13 severity severity NN cord-028034-pjotppso 59 14 and and CC cord-028034-pjotppso 59 15 death death NN cord-028034-pjotppso 59 16 of of IN cord-028034-pjotppso 59 17 patients patient NNS cord-028034-pjotppso 59 18 with with IN cord-028034-pjotppso 59 19 COVID-19 COVID-19 NNP cord-028034-pjotppso 59 20 . . . cord-028034-pjotppso 60 1 Th17 Th17 NNP cord-028034-pjotppso 60 2 , , , cord-028034-pjotppso 60 3 an an DT cord-028034-pjotppso 60 4 IL-17 IL-17 NNP cord-028034-pjotppso 60 5 secreting secrete VBG cord-028034-pjotppso 60 6 CD4 CD4 NNP cord-028034-pjotppso 60 7 + + CC cord-028034-pjotppso 60 8 T t NN cord-028034-pjotppso 60 9 cell cell NN cord-028034-pjotppso 60 10 , , , cord-028034-pjotppso 60 11 has have VBZ cord-028034-pjotppso 60 12 a a DT cord-028034-pjotppso 60 13 unique unique JJ cord-028034-pjotppso 60 14 link link NN cord-028034-pjotppso 60 15 to to TO cord-028034-pjotppso 60 16 augment augment VB cord-028034-pjotppso 60 17 the the DT cord-028034-pjotppso 60 18 function function NN cord-028034-pjotppso 60 19 of of IN cord-028034-pjotppso 60 20 neutrophil neutrophil NN cord-028034-pjotppso 60 21 . . . cord-028034-pjotppso 61 1 Vitamin vitamin NN cord-028034-pjotppso 61 2 D d NN cord-028034-pjotppso 61 3 via via IN cord-028034-pjotppso 61 4 vitamin vitamin NN cord-028034-pjotppso 61 5 D d NN cord-028034-pjotppso 61 6 receptor receptor NN cord-028034-pjotppso 61 7 ( ( -LRB- cord-028034-pjotppso 61 8 VDR VDR NNP cord-028034-pjotppso 61 9 ) ) -RRB- cord-028034-pjotppso 61 10 could could MD cord-028034-pjotppso 61 11 efficiently efficiently RB cord-028034-pjotppso 61 12 suppress suppress VB cord-028034-pjotppso 61 13 the the DT cord-028034-pjotppso 61 14 cytokine cytokine NN cord-028034-pjotppso 61 15 production production NN cord-028034-pjotppso 61 16 of of IN cord-028034-pjotppso 61 17 Th17 Th17 NNP cord-028034-pjotppso 61 18 . . . cord-028034-pjotppso 62 1 Vitamin vitamin NN cord-028034-pjotppso 62 2 C c NN cord-028034-pjotppso 62 3 could could MD cord-028034-pjotppso 62 4 decrease decrease VB cord-028034-pjotppso 62 5 the the DT cord-028034-pjotppso 62 6 number number NN cord-028034-pjotppso 62 7 of of IN cord-028034-pjotppso 62 8 neutrophils neutrophil NNS cord-028034-pjotppso 62 9 , , , cord-028034-pjotppso 62 10 escort escort VB cord-028034-pjotppso 62 11 the the DT cord-028034-pjotppso 62 12 apoptotic apoptotic JJ cord-028034-pjotppso 62 13 process process NN cord-028034-pjotppso 62 14 , , , cord-028034-pjotppso 62 15 and and CC cord-028034-pjotppso 62 16 avoid avoid VB cord-028034-pjotppso 62 17 inflammatory inflammatory JJ cord-028034-pjotppso 62 18 necrosis necrosis NN cord-028034-pjotppso 62 19 following follow VBG cord-028034-pjotppso 62 20 the the DT cord-028034-pjotppso 62 21 activation activation NN cord-028034-pjotppso 62 22 of of IN cord-028034-pjotppso 62 23 neutrophil neutrophil NN cord-028034-pjotppso 62 24 dietary dietary JJ cord-028034-pjotppso 62 25 intakes intake NNS cord-028034-pjotppso 62 26 of of IN cord-028034-pjotppso 62 27 ∼100 ∼100 NNP cord-028034-pjotppso 62 28 mg mg NNP cord-028034-pjotppso 62 29 / / SYM cord-028034-pjotppso 62 30 day day NN cord-028034-pjotppso 62 31 , , , cord-028034-pjotppso 62 32 5 5 CD cord-028034-pjotppso 62 33 it -PRON- PRP cord-028034-pjotppso 62 34 is be VBZ cord-028034-pjotppso 62 35 important important JJ cord-028034-pjotppso 62 36 to to TO cord-028034-pjotppso 62 37 use use VB cord-028034-pjotppso 62 38 safe safe JJ cord-028034-pjotppso 62 39 dose dose NN cord-028034-pjotppso 62 40 for for IN cord-028034-pjotppso 62 41 the the DT cord-028034-pjotppso 62 42 intervention intervention NN cord-028034-pjotppso 62 43 of of IN cord-028034-pjotppso 62 44 neutrophil neutrophil NN cord-028034-pjotppso 62 45 - - HYPH cord-028034-pjotppso 62 46 related relate VBN cord-028034-pjotppso 62 47 cytokine cytokine NN cord-028034-pjotppso 62 48 storm storm NN cord-028034-pjotppso 62 49 and and CC cord-028034-pjotppso 62 50 avoid avoid VB cord-028034-pjotppso 62 51 slowing slow VBG cord-028034-pjotppso 62 52 the the DT cord-028034-pjotppso 62 53 clearance clearance NN cord-028034-pjotppso 62 54 of of IN cord-028034-pjotppso 62 55 viruses virus NNS cord-028034-pjotppso 62 56 by by IN cord-028034-pjotppso 62 57 immune immune JJ cord-028034-pjotppso 62 58 response response NN cord-028034-pjotppso 62 59 . . . cord-028034-pjotppso 63 1 RDA RDA NNP cord-028034-pjotppso 63 2 for for IN cord-028034-pjotppso 63 3 Vc Vc NNP cord-028034-pjotppso 63 4 is be VBZ cord-028034-pjotppso 63 5 about about RB cord-028034-pjotppso 63 6 90 90 CD cord-028034-pjotppso 63 7 mg mg NNP cord-028034-pjotppso 63 8 daily daily RB cord-028034-pjotppso 63 9 , , , cord-028034-pjotppso 63 10 interestingly interestingly RB cord-028034-pjotppso 63 11 , , , cord-028034-pjotppso 63 12 which which WDT cord-028034-pjotppso 63 13 was be VBD cord-028034-pjotppso 63 14 selected select VBN cord-028034-pjotppso 63 15 at at IN cord-028034-pjotppso 63 16 80 80 CD cord-028034-pjotppso 63 17 % % NN cord-028034-pjotppso 63 18 saturation saturation NN cord-028034-pjotppso 63 19 of of IN cord-028034-pjotppso 63 20 neutrophils neutrophil NNS cord-028034-pjotppso 63 21 . . . cord-028034-pjotppso 64 1 12 12 CD cord-028034-pjotppso 64 2 Levin Levin NNP cord-028034-pjotppso 64 3 et et NNP cord-028034-pjotppso 64 4 al al NNP cord-028034-pjotppso 64 5 suggested suggest VBD cord-028034-pjotppso 64 6 that that IN cord-028034-pjotppso 64 7 the the DT cord-028034-pjotppso 64 8 safe safe JJ cord-028034-pjotppso 64 9 dose dose NN cord-028034-pjotppso 64 10 of of IN cord-028034-pjotppso 64 11 Vc Vc NNP cord-028034-pjotppso 64 12 was be VBD cord-028034-pjotppso 64 13 less less JJR cord-028034-pjotppso 64 14 than than IN cord-028034-pjotppso 64 15 1000 1000 CD cord-028034-pjotppso 64 16 mg mg NNP cord-028034-pjotppso 64 17 daily daily RB cord-028034-pjotppso 64 18 . . . cord-028034-pjotppso 65 1 13 13 CD cord-028034-pjotppso 66 1 Wang Wang NNP cord-028034-pjotppso 66 2 et et NNP cord-028034-pjotppso 66 3 al al NNP cord-028034-pjotppso 66 4 recently recently RB cord-028034-pjotppso 66 5 suggested suggest VBD cord-028034-pjotppso 66 6 that that IN cord-028034-pjotppso 66 7 Vc Vc NNP cord-028034-pjotppso 66 8 and and CC cord-028034-pjotppso 66 9 Vitamin vitamin NN cord-028034-pjotppso 66 10 E e NN cord-028034-pjotppso 66 11 ( ( -LRB- cord-028034-pjotppso 66 12 Ve Ve NNP cord-028034-pjotppso 66 13 ) ) -RRB- cord-028034-pjotppso 66 14 might may MD cord-028034-pjotppso 66 15 ameliorate ameliorate VB cord-028034-pjotppso 66 16 cardiac cardiac JJ cord-028034-pjotppso 66 17 injuries injury NNS cord-028034-pjotppso 66 18 of of IN cord-028034-pjotppso 66 19 COVID-19 covid-19 JJ cord-028034-pjotppso 66 20 patients patient NNS cord-028034-pjotppso 66 21 as as IN cord-028034-pjotppso 66 22 an an DT cord-028034-pjotppso 66 23 antioxidant antioxidant NN cord-028034-pjotppso 66 24 . . . cord-028034-pjotppso 66 25 14 14 CD cord-028034-pjotppso 67 1 Compared compare VBN cord-028034-pjotppso 67 2 to to IN cord-028034-pjotppso 67 3 other other JJ cord-028034-pjotppso 67 4 antioxidants antioxidant NNS cord-028034-pjotppso 67 5 and and CC cord-028034-pjotppso 67 6 water water NN cord-028034-pjotppso 67 7 - - HYPH cord-028034-pjotppso 67 8 insoluble insoluble JJ cord-028034-pjotppso 67 9 Ve Ve NNP cord-028034-pjotppso 67 10 , , , cord-028034-pjotppso 67 11 Vc Vc NNP cord-028034-pjotppso 67 12 and and CC cord-028034-pjotppso 67 13 Vd Vd NNP cord-028034-pjotppso 67 14 are be VBP cord-028034-pjotppso 67 15 preferred prefer VBN cord-028034-pjotppso 67 16 natural natural JJ cord-028034-pjotppso 67 17 substrates substrate NNS cord-028034-pjotppso 67 18 15 15 CD cord-028034-pjotppso 67 19 and and CC cord-028034-pjotppso 67 20 modulators modulator NNS cord-028034-pjotppso 67 21 of of IN cord-028034-pjotppso 67 22 neutrophil neutrophil NN cord-028034-pjotppso 67 23 function function NN cord-028034-pjotppso 67 24 and and CC cord-028034-pjotppso 67 25 fate fate NN cord-028034-pjotppso 67 26 . . . cord-028034-pjotppso 68 1 In in IN cord-028034-pjotppso 68 2 brief brief NN cord-028034-pjotppso 68 3 , , , cord-028034-pjotppso 68 4 an an DT cord-028034-pjotppso 68 5 oral oral JJ cord-028034-pjotppso 68 6 daily daily JJ cord-028034-pjotppso 68 7 dose dose NN cord-028034-pjotppso 68 8 of of IN cord-028034-pjotppso 68 9 Vc Vc NNP cord-028034-pjotppso 68 10 between between IN cord-028034-pjotppso 68 11 90 90 CD cord-028034-pjotppso 68 12 and and CC cord-028034-pjotppso 68 13 1000 1000 CD cord-028034-pjotppso 68 14 mg mg PRP cord-028034-pjotppso 68 15 might may MD cord-028034-pjotppso 68 16 avoid avoid VB cord-028034-pjotppso 68 17 inhibiting inhibit VBG cord-028034-pjotppso 68 18 innate innate JJ cord-028034-pjotppso 68 19 immunity immunity NN cord-028034-pjotppso 68 20 and and CC cord-028034-pjotppso 68 21 safeguard safeguard VB cord-028034-pjotppso 68 22 the the DT cord-028034-pjotppso 68 23 homeostasis homeostasis NN cord-028034-pjotppso 68 24 of of IN cord-028034-pjotppso 68 25 neutrophils neutrophil NNS cord-028034-pjotppso 68 26 . . . cord-028034-pjotppso 69 1 On on IN cord-028034-pjotppso 69 2 the the DT cord-028034-pjotppso 69 3 other other JJ cord-028034-pjotppso 69 4 hand hand NN cord-028034-pjotppso 69 5 , , , cord-028034-pjotppso 69 6 Cheng Cheng NNP cord-028034-pjotppso 69 7 discussed discuss VBD cord-028034-pjotppso 69 8 that that IN cord-028034-pjotppso 69 9 Vc Vc NNP cord-028034-pjotppso 69 10 up up IN cord-028034-pjotppso 69 11 to to TO cord-028034-pjotppso 69 12 1.5 1.5 CD cord-028034-pjotppso 69 13 g g NN cord-028034-pjotppso 69 14 / / SYM cord-028034-pjotppso 69 15 kg kg NN cord-028034-pjotppso 69 16 body body NN cord-028034-pjotppso 69 17 weight weight NN cord-028034-pjotppso 69 18 might may MD cord-028034-pjotppso 69 19 be be VB cord-028034-pjotppso 69 20 safe safe JJ cord-028034-pjotppso 69 21 and and CC cord-028034-pjotppso 69 22 without without IN cord-028034-pjotppso 69 23 major major JJ cord-028034-pjotppso 69 24 adverse adverse JJ cord-028034-pjotppso 69 25 events event NNS cord-028034-pjotppso 69 26 16 16 CD cord-028034-pjotppso 69 27 , , , cord-028034-pjotppso 69 28 and and CC cord-028034-pjotppso 69 29 cited cite VBD cord-028034-pjotppso 69 30 that that IN cord-028034-pjotppso 69 31 high high JJ cord-028034-pjotppso 69 32 - - HYPH cord-028034-pjotppso 69 33 dose dose NN cord-028034-pjotppso 69 34 intravenous intravenous JJ cord-028034-pjotppso 69 35 Vc Vc NNP cord-028034-pjotppso 69 36 ( ( -LRB- cord-028034-pjotppso 69 37 50 50 CD cord-028034-pjotppso 69 38 - - SYM cord-028034-pjotppso 69 39 200 200 CD cord-028034-pjotppso 69 40 mg mg NNP cord-028034-pjotppso 69 41 / / SYM cord-028034-pjotppso 69 42 kg kg NN cord-028034-pjotppso 69 43 body body NN cord-028034-pjotppso 69 44 weight weight NN cord-028034-pjotppso 69 45 ) ) -RRB- cord-028034-pjotppso 69 46 was be VBD cord-028034-pjotppso 69 47 recommended recommend VBN cord-028034-pjotppso 69 48 in in IN cord-028034-pjotppso 69 49 the the DT cord-028034-pjotppso 69 50 expert expert JJ cord-028034-pjotppso 69 51 consensus consensus NN cord-028034-pjotppso 69 52 statement statement NN cord-028034-pjotppso 69 53 on on IN cord-028034-pjotppso 69 54 comprehensive comprehensive JJ cord-028034-pjotppso 69 55 treatment treatment NN cord-028034-pjotppso 69 56 of of IN cord-028034-pjotppso 69 57 COVID-19 COVID-19 NNP cord-028034-pjotppso 69 58 from from IN cord-028034-pjotppso 69 59 Shanghai Shanghai NNP cord-028034-pjotppso 69 60 , , , cord-028034-pjotppso 69 61 China China NNP cord-028034-pjotppso 69 62 . . . cord-028034-pjotppso 70 1 17 17 CD cord-028034-pjotppso 71 1 The the DT cord-028034-pjotppso 71 2 high high JJ cord-028034-pjotppso 71 3 - - HYPH cord-028034-pjotppso 71 4 dose dose NN cord-028034-pjotppso 71 5 intravenous intravenous JJ cord-028034-pjotppso 71 6 Vc Vc NNP cord-028034-pjotppso 71 7 might may MD cord-028034-pjotppso 71 8 act act VB cord-028034-pjotppso 71 9 as as IN cord-028034-pjotppso 71 10 a a DT cord-028034-pjotppso 71 11 pro pro JJ cord-028034-pjotppso 71 12 - - JJ cord-028034-pjotppso 71 13 oxidant oxidant JJ cord-028034-pjotppso 71 14 in in IN cord-028034-pjotppso 71 15 immune immune JJ cord-028034-pjotppso 71 16 cells cell NNS cord-028034-pjotppso 71 17 and and CC cord-028034-pjotppso 71 18 induce induce VB cord-028034-pjotppso 71 19 glyceraldehyde-3-phosphate glyceraldehyde-3-phosphate JJ cord-028034-pjotppso 71 20 dehydrogenase dehydrogenase NN cord-028034-pjotppso 71 21 inhibition inhibition NN cord-028034-pjotppso 71 22 and and CC cord-028034-pjotppso 71 23 related related JJ cord-028034-pjotppso 71 24 immunosuppression immunosuppression NN cord-028034-pjotppso 71 25 via via IN cord-028034-pjotppso 71 26 NAD NAD NNP cord-028034-pjotppso 71 27 + + CC cord-028034-pjotppso 71 28 ( ( -LRB- cord-028034-pjotppso 71 29 nicotinamide nicotinamide NN cord-028034-pjotppso 71 30 adenine adenine NN cord-028034-pjotppso 71 31 dinucleotide dinucleotide NN cord-028034-pjotppso 71 32 ) ) -RRB- cord-028034-pjotppso 71 33 depletion depletion NN cord-028034-pjotppso 71 34 . . . cord-028034-pjotppso 72 1 18 18 CD cord-028034-pjotppso 73 1 Due due IN cord-028034-pjotppso 73 2 to to IN cord-028034-pjotppso 73 3 the the DT cord-028034-pjotppso 73 4 roles role NNS cord-028034-pjotppso 73 5 of of IN cord-028034-pjotppso 73 6 high high JJ cord-028034-pjotppso 73 7 - - HYPH cord-028034-pjotppso 73 8 dose dose NN cord-028034-pjotppso 73 9 Vc Vc NNP cord-028034-pjotppso 73 10 in in IN cord-028034-pjotppso 73 11 immunosuppression immunosuppression NN cord-028034-pjotppso 73 12 , , , cord-028034-pjotppso 73 13 the the DT cord-028034-pjotppso 73 14 dosage dosage NN cord-028034-pjotppso 73 15 of of IN cord-028034-pjotppso 73 16 Vc Vc NNP cord-028034-pjotppso 73 17 should should MD cord-028034-pjotppso 73 18 be be VB cord-028034-pjotppso 73 19 deliberated deliberate VBN cord-028034-pjotppso 73 20 on on IN cord-028034-pjotppso 73 21 the the DT cord-028034-pjotppso 73 22 details detail NNS cord-028034-pjotppso 73 23 to to TO cord-028034-pjotppso 73 24 take take VB cord-028034-pjotppso 73 25 into into IN cord-028034-pjotppso 73 26 account account NN cord-028034-pjotppso 73 27 the the DT cord-028034-pjotppso 73 28 delay delay NN cord-028034-pjotppso 73 29 of of IN cord-028034-pjotppso 73 30 virus virus NN cord-028034-pjotppso 73 31 clearance clearance NN cord-028034-pjotppso 73 32 . . . cord-028034-pjotppso 74 1 This this DT cord-028034-pjotppso 74 2 perspective perspective NN cord-028034-pjotppso 74 3 focused focus VBD cord-028034-pjotppso 74 4 on on IN cord-028034-pjotppso 74 5 the the DT cord-028034-pjotppso 74 6 aberration aberration NN cord-028034-pjotppso 74 7 of of IN cord-028034-pjotppso 74 8 neutrophil neutrophil NN cord-028034-pjotppso 74 9 as as IN cord-028034-pjotppso 74 10 one one CD cord-028034-pjotppso 74 11 of of IN cord-028034-pjotppso 74 12 the the DT cord-028034-pjotppso 74 13 clinical clinical JJ cord-028034-pjotppso 74 14 characteristics characteristic NNS cord-028034-pjotppso 74 15 of of IN cord-028034-pjotppso 74 16 COVID-19 COVID-19 NNP cord-028034-pjotppso 74 17 . . NNP cord-028034-pjotppso 74 18 1 1 CD cord-028034-pjotppso 74 19 - - SYM cord-028034-pjotppso 74 20 3 3 CD cord-028034-pjotppso 75 1 Consequently consequently RB cord-028034-pjotppso 75 2 , , , cord-028034-pjotppso 75 3 the the DT cord-028034-pjotppso 75 4 dose dose NN cord-028034-pjotppso 75 5 ranges range NNS cord-028034-pjotppso 75 6 of of IN cord-028034-pjotppso 75 7 Vc Vc NNP cord-028034-pjotppso 75 8 and and CC cord-028034-pjotppso 75 9 Vd Vd NNP cord-028034-pjotppso 75 10 among among IN cord-028034-pjotppso 75 11 90 90 CD cord-028034-pjotppso 75 12 - - SYM cord-028034-pjotppso 75 13 1000 1000 CD cord-028034-pjotppso 75 14 mg mg NN cord-028034-pjotppso 75 15 and and CC cord-028034-pjotppso 75 16 400 400 CD cord-028034-pjotppso 75 17 - - SYM cord-028034-pjotppso 75 18 1600 1600 CD cord-028034-pjotppso 75 19 IU IU NNP cord-028034-pjotppso 75 20 , , , cord-028034-pjotppso 75 21 respectively respectively RB cord-028034-pjotppso 75 22 , , , cord-028034-pjotppso 75 23 might may MD cord-028034-pjotppso 75 24 be be VB cord-028034-pjotppso 75 25 enough enough JJ cord-028034-pjotppso 75 26 and and CC cord-028034-pjotppso 75 27 safe safe JJ cord-028034-pjotppso 75 28 for for IN cord-028034-pjotppso 75 29 the the DT cord-028034-pjotppso 75 30 prevention prevention NN cord-028034-pjotppso 75 31 or or CC cord-028034-pjotppso 75 32 treatment treatment NN cord-028034-pjotppso 75 33 of of IN cord-028034-pjotppso 75 34 the the DT cord-028034-pjotppso 75 35 cytokine cytokine NN cord-028034-pjotppso 75 36 storm storm NN cord-028034-pjotppso 75 37 caused cause VBN cord-028034-pjotppso 75 38 by by IN cord-028034-pjotppso 75 39 neutrophil neutrophil NN cord-028034-pjotppso 75 40 , , , cord-028034-pjotppso 75 41 whereas whereas IN cord-028034-pjotppso 75 42 for for IN cord-028034-pjotppso 75 43 the the DT cord-028034-pjotppso 75 44 cases case NNS cord-028034-pjotppso 75 45 not not RB cord-028034-pjotppso 75 46 related relate VBN cord-028034-pjotppso 75 47 to to IN cord-028034-pjotppso 75 48 neutrophil neutrophil NN cord-028034-pjotppso 75 49 , , , cord-028034-pjotppso 75 50 high high JJ cord-028034-pjotppso 75 51 dose dose NN cord-028034-pjotppso 75 52 of of IN cord-028034-pjotppso 75 53 Vc Vc NNP cord-028034-pjotppso 75 54 or or CC cord-028034-pjotppso 75 55 Vd Vd NNP cord-028034-pjotppso 75 56 might may MD cord-028034-pjotppso 75 57 be be VB cord-028034-pjotppso 75 58 also also RB cord-028034-pjotppso 75 59 helpful helpful JJ cord-028034-pjotppso 75 60 for for IN cord-028034-pjotppso 75 61 the the DT cord-028034-pjotppso 75 62 treatment treatment NN cord-028034-pjotppso 75 63 of of IN cord-028034-pjotppso 75 64 COVID-19 covid-19 JJ cord-028034-pjotppso 75 65 patients patient NNS cord-028034-pjotppso 75 66 due due JJ cord-028034-pjotppso 75 67 to to IN cord-028034-pjotppso 75 68 the the DT cord-028034-pjotppso 75 69 multifaceted multifaceted JJ cord-028034-pjotppso 75 70 roles role NNS cord-028034-pjotppso 75 71 of of IN cord-028034-pjotppso 75 72 Vd Vd NNP cord-028034-pjotppso 75 73 and and CC cord-028034-pjotppso 75 74 Vc Vc NNP cord-028034-pjotppso 75 75 . . NNP cord-028034-pjotppso 75 76 9 9 CD cord-028034-pjotppso 75 77 , , , cord-028034-pjotppso 75 78 16 16 CD cord-028034-pjotppso 75 79 , , , cord-028034-pjotppso 75 80 18 18 CD cord-028034-pjotppso 75 81 As as IN cord-028034-pjotppso 75 82 the the DT cord-028034-pjotppso 75 83 global global JJ cord-028034-pjotppso 75 84 pandemic pandemic NN cord-028034-pjotppso 75 85 is be VBZ cord-028034-pjotppso 75 86 still still RB cord-028034-pjotppso 75 87 growing grow VBG cord-028034-pjotppso 75 88 , , , cord-028034-pjotppso 75 89 if if IN cord-028034-pjotppso 75 90 the the DT cord-028034-pjotppso 75 91 vitamin vitamin NN cord-028034-pjotppso 75 92 intervention intervention NN cord-028034-pjotppso 75 93 for for IN cord-028034-pjotppso 75 94 cytokine cytokine NN cord-028034-pjotppso 75 95 storm storm NN cord-028034-pjotppso 75 96 could could MD cord-028034-pjotppso 75 97 be be VB cord-028034-pjotppso 75 98 proved prove VBN cord-028034-pjotppso 75 99 to to TO cord-028034-pjotppso 75 100 be be VB cord-028034-pjotppso 75 101 applicable applicable JJ cord-028034-pjotppso 75 102 and and CC cord-028034-pjotppso 75 103 efficient efficient JJ cord-028034-pjotppso 75 104 , , , cord-028034-pjotppso 75 105 it -PRON- PRP cord-028034-pjotppso 75 106 would would MD cord-028034-pjotppso 75 107 be be VB cord-028034-pjotppso 75 108 tremendously tremendously RB cord-028034-pjotppso 75 109 helpful helpful JJ cord-028034-pjotppso 75 110 and and CC cord-028034-pjotppso 75 111 easy easy JJ cord-028034-pjotppso 75 112 to to TO cord-028034-pjotppso 75 113 protect protect VB cord-028034-pjotppso 75 114 the the DT cord-028034-pjotppso 75 115 patients patient NNS cord-028034-pjotppso 75 116 with with IN cord-028034-pjotppso 75 117 COVID-19 COVID-19 , cord-028034-pjotppso 75 118 worldwide worldwide RB cord-028034-pjotppso 75 119 from from IN cord-028034-pjotppso 75 120 the the DT cord-028034-pjotppso 75 121 cytokine cytokine NN cord-028034-pjotppso 75 122 storm storm NN cord-028034-pjotppso 75 123 - - HYPH cord-028034-pjotppso 75 124 related relate VBN cord-028034-pjotppso 75 125 death death NN cord-028034-pjotppso 75 126 . . . cord-028034-pjotppso 76 1 Clinical clinical JJ cord-028034-pjotppso 76 2 features feature NNS cord-028034-pjotppso 76 3 of of IN cord-028034-pjotppso 76 4 patients patient NNS cord-028034-pjotppso 76 5 infected infect VBN cord-028034-pjotppso 76 6 with with IN cord-028034-pjotppso 76 7 2019 2019 CD cord-028034-pjotppso 76 8 novel novel JJ cord-028034-pjotppso 76 9 coronavirus coronavirus NN cord-028034-pjotppso 76 10 in in IN cord-028034-pjotppso 76 11 Wuhan Wuhan NNP cord-028034-pjotppso 76 12 Clinical clinical JJ cord-028034-pjotppso 76 13 characteristics characteristic NNS cord-028034-pjotppso 76 14 of of IN cord-028034-pjotppso 76 15 138 138 CD cord-028034-pjotppso 76 16 hospitalized hospitalize VBN cord-028034-pjotppso 76 17 patients patient NNS cord-028034-pjotppso 76 18 with with IN cord-028034-pjotppso 76 19 2019 2019 CD cord-028034-pjotppso 76 20 novel novel JJ cord-028034-pjotppso 76 21 coronavirus coronavirus NN cord-028034-pjotppso 76 22 - - HYPH cord-028034-pjotppso 76 23 infected infect VBN cord-028034-pjotppso 76 24 pneumonia pneumonia NN cord-028034-pjotppso 76 25 in in IN cord-028034-pjotppso 76 26 Wuhan Wuhan NNP cord-028034-pjotppso 76 27 Clinical clinical JJ cord-028034-pjotppso 76 28 characteristics characteristic NNS cord-028034-pjotppso 76 29 of of IN cord-028034-pjotppso 76 30 coronavirus coronavirus NN cord-028034-pjotppso 76 31 disease disease NN cord-028034-pjotppso 76 32 2019 2019 CD cord-028034-pjotppso 76 33 in in IN cord-028034-pjotppso 76 34 China China NNP cord-028034-pjotppso 77 1 Lymphopenia Lymphopenia NNP cord-028034-pjotppso 77 2 predicts predict VBZ cord-028034-pjotppso 77 3 disease disease NN cord-028034-pjotppso 77 4 severity severity NN cord-028034-pjotppso 77 5 of of IN cord-028034-pjotppso 77 6 COVID-19 COVID-19 NNP cord-028034-pjotppso 77 7 : : : cord-028034-pjotppso 77 8 a a DT cord-028034-pjotppso 77 9 descriptive descriptive JJ cord-028034-pjotppso 77 10 and and CC cord-028034-pjotppso 77 11 predictive predictive JJ cord-028034-pjotppso 77 12 study study NN cord-028034-pjotppso 77 13 Vitamin vitamin NN cord-028034-pjotppso 77 14 C c NN cord-028034-pjotppso 77 15 and and CC cord-028034-pjotppso 77 16 immune immune JJ cord-028034-pjotppso 77 17 function function NN cord-028034-pjotppso 78 1 The the DT cord-028034-pjotppso 78 2 Th17 Th17 NNP cord-028034-pjotppso 78 3 pathway pathway NN cord-028034-pjotppso 78 4 and and CC cord-028034-pjotppso 78 5 inflammatory inflammatory JJ cord-028034-pjotppso 78 6 diseases disease NNS cord-028034-pjotppso 78 7 of of IN cord-028034-pjotppso 78 8 the the DT cord-028034-pjotppso 78 9 intestines intestine NNS cord-028034-pjotppso 78 10 , , , cord-028034-pjotppso 78 11 lungs lung NNS cord-028034-pjotppso 78 12 and and CC cord-028034-pjotppso 78 13 skin skin NN cord-028034-pjotppso 78 14 Vitamin vitamin NN cord-028034-pjotppso 78 15 D d NN cord-028034-pjotppso 78 16 suppresses suppress VBZ cord-028034-pjotppso 78 17 Th17 th17 CD cord-028034-pjotppso 78 18 cytokine cytokine NN cord-028034-pjotppso 78 19 production production NN cord-028034-pjotppso 78 20 by by IN cord-028034-pjotppso 78 21 inducing induce VBG cord-028034-pjotppso 79 1 C C NNP cord-028034-pjotppso 79 2 / / SYM cord-028034-pjotppso 79 3 EBP ebp NN cord-028034-pjotppso 79 4 homologous homologous JJ cord-028034-pjotppso 79 5 protein protein NN cord-028034-pjotppso 79 6 ( ( -LRB- cord-028034-pjotppso 79 7 CHOP CHOP NNP cord-028034-pjotppso 79 8 ) ) -RRB- cord-028034-pjotppso 79 9 expression expression NN cord-028034-pjotppso 80 1 Dietary dietary JJ cord-028034-pjotppso 80 2 vitamin vitamin NN cord-028034-pjotppso 80 3 D d NN cord-028034-pjotppso 80 4 intake intake NN cord-028034-pjotppso 80 5 for for IN cord-028034-pjotppso 80 6 the the DT cord-028034-pjotppso 80 7 elderly elderly JJ cord-028034-pjotppso 80 8 population population NN cord-028034-pjotppso 80 9 : : : cord-028034-pjotppso 81 1 update update VB cord-028034-pjotppso 81 2 on on IN cord-028034-pjotppso 81 3 the the DT cord-028034-pjotppso 81 4 Recommended Recommended NNP cord-028034-pjotppso 81 5 Dietary Dietary NNP cord-028034-pjotppso 81 6 Allowance Allowance NNP cord-028034-pjotppso 81 7 ( ( -LRB- cord-028034-pjotppso 81 8 RDA RDA NNP cord-028034-pjotppso 81 9 ) ) -RRB- cord-028034-pjotppso 81 10 for for IN cord-028034-pjotppso 81 11 vitamin vitamin NN cord-028034-pjotppso 81 12 D d NN cord-028034-pjotppso 81 13 Evidence evidence NN cord-028034-pjotppso 81 14 that that IN cord-028034-pjotppso 81 15 vitamin vitamin NN cord-028034-pjotppso 81 16 D d NN cord-028034-pjotppso 81 17 supplementation supplementation NN cord-028034-pjotppso 81 18 could could MD cord-028034-pjotppso 81 19 reduce reduce VB cord-028034-pjotppso 81 20 risk risk NN cord-028034-pjotppso 81 21 of of IN cord-028034-pjotppso 81 22 influenza influenza NN cord-028034-pjotppso 81 23 and and CC cord-028034-pjotppso 81 24 COVID-19 covid-19 JJ cord-028034-pjotppso 81 25 infections infection NNS cord-028034-pjotppso 81 26 and and CC cord-028034-pjotppso 81 27 deaths death NNS cord-028034-pjotppso 82 1 Backman Backman NNP cord-028034-pjotppso 82 2 V. V. NNP cord-028034-pjotppso 83 1 The the DT cord-028034-pjotppso 83 2 role role NN cord-028034-pjotppso 83 3 of of IN cord-028034-pjotppso 83 4 vitamin vitamin NN cord-028034-pjotppso 83 5 D d NN cord-028034-pjotppso 83 6 in in IN cord-028034-pjotppso 83 7 suppressing suppress VBG cord-028034-pjotppso 83 8 cytokine cytokine JJ cord-028034-pjotppso 83 9 storm storm NN cord-028034-pjotppso 83 10 in in IN cord-028034-pjotppso 83 11 COVID-19 covid-19 JJ cord-028034-pjotppso 83 12 patients patient NNS cord-028034-pjotppso 83 13 and and CC cord-028034-pjotppso 83 14 associated associate VBD cord-028034-pjotppso 83 15 mortality mortality NN cord-028034-pjotppso 83 16 Inhibition inhibition NN cord-028034-pjotppso 83 17 of of IN cord-028034-pjotppso 83 18 tumor tumor NN cord-028034-pjotppso 83 19 cell cell NN cord-028034-pjotppso 83 20 growth growth NN cord-028034-pjotppso 83 21 by by IN cord-028034-pjotppso 83 22 interferongamma interferongamma NNP cord-028034-pjotppso 83 23 is be VBZ cord-028034-pjotppso 83 24 mediated mediate VBN cord-028034-pjotppso 83 25 by by IN cord-028034-pjotppso 83 26 two two CD cord-028034-pjotppso 83 27 distinct distinct JJ cord-028034-pjotppso 83 28 mechanisms mechanism NNS cord-028034-pjotppso 83 29 dependent dependent JJ cord-028034-pjotppso 83 30 upon upon IN cord-028034-pjotppso 83 31 oxygen oxygen NN cord-028034-pjotppso 83 32 tension tension NN cord-028034-pjotppso 83 33 : : : cord-028034-pjotppso 83 34 induction induction NN cord-028034-pjotppso 83 35 of of IN cord-028034-pjotppso 83 36 tryptophan tryptophan NN cord-028034-pjotppso 83 37 degradation degradation NN cord-028034-pjotppso 83 38 and and CC cord-028034-pjotppso 83 39 depletion depletion NN cord-028034-pjotppso 83 40 of of IN cord-028034-pjotppso 83 41 intracellular intracellular JJ cord-028034-pjotppso 83 42 nicotinamide nicotinamide NN cord-028034-pjotppso 83 43 adenine adenine NN cord-028034-pjotppso 83 44 dinucleotide dinucleotide NN cord-028034-pjotppso 84 1 A a DT cord-028034-pjotppso 84 2 new new JJ cord-028034-pjotppso 84 3 recommended recommend VBN cord-028034-pjotppso 84 4 dietary dietary JJ cord-028034-pjotppso 84 5 allowance allowance NN cord-028034-pjotppso 84 6 of of IN cord-028034-pjotppso 84 7 vitamin vitamin NN cord-028034-pjotppso 84 8 C c NN cord-028034-pjotppso 84 9 for for IN cord-028034-pjotppso 84 10 healthy healthy JJ cord-028034-pjotppso 84 11 young young JJ cord-028034-pjotppso 84 12 women woman NNS cord-028034-pjotppso 84 13 Vitamin vitamin NN cord-028034-pjotppso 84 14 C c NN cord-028034-pjotppso 84 15 pharmacokinetics pharmacokinetic NNS cord-028034-pjotppso 84 16 in in IN cord-028034-pjotppso 84 17 healthy healthy JJ cord-028034-pjotppso 84 18 volunteers volunteer NNS cord-028034-pjotppso 84 19 : : : cord-028034-pjotppso 84 20 evidence evidence NN cord-028034-pjotppso 84 21 for for IN cord-028034-pjotppso 84 22 a a DT cord-028034-pjotppso 84 23 recommended recommend VBN cord-028034-pjotppso 84 24 dietary dietary JJ cord-028034-pjotppso 84 25 allowance allowance NN cord-028034-pjotppso 85 1 An an DT cord-028034-pjotppso 85 2 anti anti JJ cord-028034-pjotppso 85 3 - - JJ cord-028034-pjotppso 85 4 oxidative oxidative JJ cord-028034-pjotppso 85 5 therapy therapy NN cord-028034-pjotppso 85 6 for for IN cord-028034-pjotppso 85 7 ameliorating ameliorate VBG cord-028034-pjotppso 85 8 cardiac cardiac JJ cord-028034-pjotppso 85 9 injuries injury NNS cord-028034-pjotppso 85 10 of of IN cord-028034-pjotppso 85 11 critically critically RB cord-028034-pjotppso 85 12 ill ill JJ cord-028034-pjotppso 85 13 COVID-19 COVID-19 NNP cord-028034-pjotppso 85 14 Rheumatologists Rheumatologists NNPS cord-028034-pjotppso 85 15 ' ' POS cord-028034-pjotppso 85 16 perspective perspective NN cord-028034-pjotppso 85 17 on on IN cord-028034-pjotppso 85 18 coronavirus coronavirus NN cord-028034-pjotppso 85 19 disease disease NN cord-028034-pjotppso 85 20 19 19 CD cord-028034-pjotppso 85 21 ( ( -LRB- cord-028034-pjotppso 85 22 COVID-19 COVID-19 NNP cord-028034-pjotppso 85 23 ) ) -RRB- cord-028034-pjotppso 85 24 and and CC cord-028034-pjotppso 85 25 potential potential JJ cord-028034-pjotppso 85 26 therapeutic therapeutic JJ cord-028034-pjotppso 85 27 targets target NNS cord-028034-pjotppso 86 1 Can Can MD cord-028034-pjotppso 86 2 early early JJ cord-028034-pjotppso 86 3 and and CC cord-028034-pjotppso 86 4 high high JJ cord-028034-pjotppso 86 5 intravenous intravenous JJ cord-028034-pjotppso 86 6 dose dose NN cord-028034-pjotppso 86 7 of of IN cord-028034-pjotppso 86 8 vitamin vitamin NN cord-028034-pjotppso 86 9 C c NN cord-028034-pjotppso 86 10 prevent prevent VBP cord-028034-pjotppso 86 11 and and CC cord-028034-pjotppso 86 12 treat treat VBP cord-028034-pjotppso 86 13 coronavirus coronavirus NN cord-028034-pjotppso 86 14 disease disease NN cord-028034-pjotppso 86 15 2019 2019 CD cord-028034-pjotppso 86 16 ( ( -LRB- cord-028034-pjotppso 86 17 COVID-19 COVID-19 NNP cord-028034-pjotppso 86 18 Shanghai Shanghai NNP cord-028034-pjotppso 86 19 Clinical Clinical NNP cord-028034-pjotppso 86 20 Treatment Treatment NNP cord-028034-pjotppso 86 21 Expert Expert NNP cord-028034-pjotppso 86 22 Group Group NNP cord-028034-pjotppso 86 23 for for IN cord-028034-pjotppso 86 24 corona corona NNP cord-028034-pjotppso 86 25 virus virus NN cord-028034-pjotppso 86 26 disease disease NNP cord-028034-pjotppso 86 27 2019 2019 CD cord-028034-pjotppso 86 28 . . . cord-028034-pjotppso 87 1 Comprehensive comprehensive JJ cord-028034-pjotppso 87 2 treatment treatment NN cord-028034-pjotppso 87 3 and and CC cord-028034-pjotppso 87 4 management management NN cord-028034-pjotppso 87 5 of of IN cord-028034-pjotppso 87 6 corona corona NNP cord-028034-pjotppso 87 7 virus virus NN cord-028034-pjotppso 87 8 disease disease NNP cord-028034-pjotppso 87 9 2019 2019 CD cord-028034-pjotppso 87 10 : : : cord-028034-pjotppso 87 11 expert expert JJ cord-028034-pjotppso 87 12 consensus consensus NN cord-028034-pjotppso 87 13 statement statement NN cord-028034-pjotppso 87 14 from from IN cord-028034-pjotppso 87 15 Shanghai Shanghai NNP cord-028034-pjotppso 87 16 High High NNP cord-028034-pjotppso 87 17 - - HYPH cord-028034-pjotppso 87 18 dose dose NN cord-028034-pjotppso 87 19 intravenous intravenous JJ cord-028034-pjotppso 87 20 vitamin vitamin NN cord-028034-pjotppso 87 21 C c NN cord-028034-pjotppso 87 22 treatment treatment NN cord-028034-pjotppso 87 23 for for IN cord-028034-pjotppso 87 24 COVID-19 COVID-19 NNP cord-028034-pjotppso 88 1 The the DT cord-028034-pjotppso 88 2 author author NN cord-028034-pjotppso 88 3 declares declare VBZ cord-028034-pjotppso 88 4 no no DT cord-028034-pjotppso 88 5 conflict conflict NN cord-028034-pjotppso 88 6 of of IN cord-028034-pjotppso 88 7 interest interest NN cord-028034-pjotppso 88 8 . . . cord-028034-pjotppso 88 9 _SP