id sid tid token lemma pos cord-011793-hlktpla4 1 1 key key JJ cord-011793-hlktpla4 1 2 : : : cord-011793-hlktpla4 1 3 cord-011793-hlktpla4 cord-011793-hlktpla4 NN cord-011793-hlktpla4 1 4 authors author NNS cord-011793-hlktpla4 1 5 : : : cord-011793-hlktpla4 1 6 Rice Rice NNP cord-011793-hlktpla4 1 7 , , , cord-011793-hlktpla4 1 8 Todd Todd NNP cord-011793-hlktpla4 1 9 W. W. NNP cord-011793-hlktpla4 1 10 ; ; : cord-011793-hlktpla4 1 11 Janz Janz NNP cord-011793-hlktpla4 1 12 , , , cord-011793-hlktpla4 1 13 David David NNP cord-011793-hlktpla4 1 14 R. R. NNP cord-011793-hlktpla4 1 15 title title NN cord-011793-hlktpla4 1 16 : : : cord-011793-hlktpla4 2 1 In in IN cord-011793-hlktpla4 2 2 Defense Defense NNP cord-011793-hlktpla4 2 3 of of IN cord-011793-hlktpla4 2 4 Evidence evidence NN cord-011793-hlktpla4 2 5 - - HYPH cord-011793-hlktpla4 2 6 based base VBN cord-011793-hlktpla4 2 7 Medicine Medicine NNP cord-011793-hlktpla4 2 8 for for IN cord-011793-hlktpla4 2 9 the the DT cord-011793-hlktpla4 2 10 Treatment Treatment NNP cord-011793-hlktpla4 2 11 of of IN cord-011793-hlktpla4 2 12 COVID-19 COVID-19 NNP cord-011793-hlktpla4 2 13 Acute Acute NNP cord-011793-hlktpla4 2 14 Respiratory Respiratory NNP cord-011793-hlktpla4 2 15 Distress Distress NNP cord-011793-hlktpla4 2 16 Syndrome Syndrome NNP cord-011793-hlktpla4 2 17 date date NN cord-011793-hlktpla4 2 18 : : : cord-011793-hlktpla4 2 19 2020 2020 CD cord-011793-hlktpla4 2 20 - - HYPH cord-011793-hlktpla4 2 21 07 07 CD cord-011793-hlktpla4 2 22 - - SYM cord-011793-hlktpla4 2 23 17 17 CD cord-011793-hlktpla4 2 24 journal journal NN cord-011793-hlktpla4 2 25 : : : cord-011793-hlktpla4 3 1 Ann Ann NNP cord-011793-hlktpla4 3 2 Am Am NNP cord-011793-hlktpla4 4 1 Thorac Thorac NNP cord-011793-hlktpla4 4 2 Soc Soc NNP cord-011793-hlktpla4 4 3 DOI DOI NNP cord-011793-hlktpla4 4 4 : : : cord-011793-hlktpla4 4 5 10.1513 10.1513 CD cord-011793-hlktpla4 4 6 / / SYM cord-011793-hlktpla4 4 7 annalsats.202004 annalsats.202004 NNP cord-011793-hlktpla4 4 8 - - HYPH cord-011793-hlktpla4 4 9 325ip 325ip NNP cord-011793-hlktpla4 4 10 sha sha NNP cord-011793-hlktpla4 4 11 : : : cord-011793-hlktpla4 5 1 7597af14544ede9a1dc53ccaa8a29dbac7dbd590 7597af14544ede9a1dc53ccaa8a29dbac7dbd590 CD cord-011793-hlktpla4 5 2 doc_id doc_id CD cord-011793-hlktpla4 5 3 : : : cord-011793-hlktpla4 5 4 11793 11793 CD cord-011793-hlktpla4 6 1 cord_uid cord_uid NN cord-011793-hlktpla4 6 2 : : : cord-011793-hlktpla4 7 1 hlktpla4 hlktpla4 NNP cord-011793-hlktpla4 8 1 nan nan NNP cord-011793-hlktpla4 8 2 Severe severe JJ cord-011793-hlktpla4 8 3 acute acute JJ cord-011793-hlktpla4 8 4 respiratory respiratory JJ cord-011793-hlktpla4 8 5 failure failure NN cord-011793-hlktpla4 8 6 from from IN cord-011793-hlktpla4 8 7 the the DT cord-011793-hlktpla4 8 8 severe severe JJ cord-011793-hlktpla4 8 9 acute acute JJ cord-011793-hlktpla4 8 10 respiratory respiratory JJ cord-011793-hlktpla4 8 11 syndrome syndrome NN cord-011793-hlktpla4 8 12 coronavirus coronavirus NN cord-011793-hlktpla4 8 13 2 2 CD cord-011793-hlktpla4 9 1 ( ( -LRB- cord-011793-hlktpla4 9 2 SARS SARS NNP cord-011793-hlktpla4 9 3 - - HYPH cord-011793-hlktpla4 9 4 CoV-2 CoV-2 NNP cord-011793-hlktpla4 9 5 ) ) -RRB- cord-011793-hlktpla4 10 1 coronavirus coronavirus NN cord-011793-hlktpla4 10 2 disease disease NN cord-011793-hlktpla4 10 3 has have VBZ cord-011793-hlktpla4 10 4 challenged challenge VBN cord-011793-hlktpla4 10 5 intensivists intensivist NNS cord-011793-hlktpla4 10 6 worldwide worldwide RB cord-011793-hlktpla4 10 7 with with IN cord-011793-hlktpla4 10 8 both both CC cord-011793-hlktpla4 10 9 increased increase VBN cord-011793-hlktpla4 10 10 severity severity NN cord-011793-hlktpla4 10 11 of of IN cord-011793-hlktpla4 10 12 illness illness NN cord-011793-hlktpla4 10 13 and and CC cord-011793-hlktpla4 10 14 quantity quantity NN cord-011793-hlktpla4 10 15 of of IN cord-011793-hlktpla4 10 16 patients patient NNS cord-011793-hlktpla4 10 17 . . . cord-011793-hlktpla4 11 1 An an DT cord-011793-hlktpla4 11 2 extraordinary extraordinary JJ cord-011793-hlktpla4 11 3 amount amount NN cord-011793-hlktpla4 11 4 has have VBZ cord-011793-hlktpla4 11 5 been be VBN cord-011793-hlktpla4 11 6 published publish VBN cord-011793-hlktpla4 11 7 about about IN cord-011793-hlktpla4 11 8 presentation presentation NN cord-011793-hlktpla4 11 9 , , , cord-011793-hlktpla4 11 10 treatment treatment NN cord-011793-hlktpla4 11 11 , , , cord-011793-hlktpla4 11 12 and and CC cord-011793-hlktpla4 11 13 outcomes outcome NNS cord-011793-hlktpla4 11 14 of of IN cord-011793-hlktpla4 11 15 these these DT cord-011793-hlktpla4 11 16 patients patient NNS cord-011793-hlktpla4 11 17 in in IN cord-011793-hlktpla4 11 18 both both CC cord-011793-hlktpla4 11 19 medical medical JJ cord-011793-hlktpla4 11 20 journals journal NNS cord-011793-hlktpla4 11 21 and and CC cord-011793-hlktpla4 11 22 social social JJ cord-011793-hlktpla4 11 23 media medium NNS cord-011793-hlktpla4 11 24 . . . cord-011793-hlktpla4 12 1 Less Less JJR cord-011793-hlktpla4 12 2 than than IN cord-011793-hlktpla4 12 3 6 6 CD cord-011793-hlktpla4 12 4 months month NNS cord-011793-hlktpla4 12 5 since since IN cord-011793-hlktpla4 12 6 the the DT cord-011793-hlktpla4 12 7 first first JJ cord-011793-hlktpla4 12 8 reported report VBN cord-011793-hlktpla4 12 9 case case NN cord-011793-hlktpla4 12 10 , , , cord-011793-hlktpla4 12 11 a a DT cord-011793-hlktpla4 12 12 search search NN cord-011793-hlktpla4 12 13 for for IN cord-011793-hlktpla4 12 14 COVID-19 COVID-19 NNP cord-011793-hlktpla4 12 15 in in IN cord-011793-hlktpla4 12 16 PubMed PubMed NNP cord-011793-hlktpla4 12 17 finds find VBZ cord-011793-hlktpla4 12 18 more more JJR cord-011793-hlktpla4 12 19 than than IN cord-011793-hlktpla4 12 20 5,000 5,000 CD cord-011793-hlktpla4 12 21 publications publication NNS cord-011793-hlktpla4 12 22 . . . cord-011793-hlktpla4 13 1 Unfortunately unfortunately RB cord-011793-hlktpla4 13 2 , , , cord-011793-hlktpla4 13 3 most most JJS cord-011793-hlktpla4 13 4 of of IN cord-011793-hlktpla4 13 5 these these DT cord-011793-hlktpla4 13 6 reports report NNS cord-011793-hlktpla4 13 7 are be VBP cord-011793-hlktpla4 13 8 anecdotal anecdotal JJ cord-011793-hlktpla4 13 9 , , , cord-011793-hlktpla4 13 10 with with IN cord-011793-hlktpla4 13 11 few few JJ cord-011793-hlktpla4 13 12 comparative comparative JJ cord-011793-hlktpla4 13 13 , , , cord-011793-hlktpla4 13 14 scientific scientific JJ cord-011793-hlktpla4 13 15 studies study NNS cord-011793-hlktpla4 13 16 among among IN cord-011793-hlktpla4 13 17 them -PRON- PRP cord-011793-hlktpla4 13 18 . . . cord-011793-hlktpla4 14 1 Similarly similarly RB cord-011793-hlktpla4 14 2 , , , cord-011793-hlktpla4 14 3 Twitter Twitter NNP cord-011793-hlktpla4 14 4 and and CC cord-011793-hlktpla4 14 5 other other JJ cord-011793-hlktpla4 14 6 social social JJ cord-011793-hlktpla4 14 7 media medium NNS cord-011793-hlktpla4 14 8 platforms platform NNS cord-011793-hlktpla4 14 9 have have VBP cord-011793-hlktpla4 14 10 been be VBN cord-011793-hlktpla4 14 11 abuzz abuzz JJ cord-011793-hlktpla4 14 12 with with IN cord-011793-hlktpla4 14 13 anecdotes anecdote NNS cord-011793-hlktpla4 14 14 and and CC cord-011793-hlktpla4 14 15 " " `` cord-011793-hlktpla4 14 16 expert expert JJ cord-011793-hlktpla4 14 17 " " '' cord-011793-hlktpla4 14 18 advice advice NN cord-011793-hlktpla4 14 19 as as IN cord-011793-hlktpla4 14 20 to to IN cord-011793-hlktpla4 14 21 how how WRB cord-011793-hlktpla4 14 22 to to TO cord-011793-hlktpla4 14 23 care care VB cord-011793-hlktpla4 14 24 for for IN cord-011793-hlktpla4 14 25 these these DT cord-011793-hlktpla4 14 26 patients patient NNS cord-011793-hlktpla4 14 27 . . . cord-011793-hlktpla4 15 1 Many many JJ cord-011793-hlktpla4 15 2 of of IN cord-011793-hlktpla4 15 3 those those DT cord-011793-hlktpla4 15 4 pieces piece NNS cord-011793-hlktpla4 15 5 of of IN cord-011793-hlktpla4 15 6 advice advice NN cord-011793-hlktpla4 15 7 have have VBP cord-011793-hlktpla4 15 8 represented represent VBN cord-011793-hlktpla4 15 9 small small JJ cord-011793-hlktpla4 15 10 - - HYPH cord-011793-hlktpla4 15 11 sample sample NN cord-011793-hlktpla4 15 12 clinical clinical JJ cord-011793-hlktpla4 15 13 experience experience NN cord-011793-hlktpla4 15 14 or or CC cord-011793-hlktpla4 15 15 uncontrolled uncontrolled JJ cord-011793-hlktpla4 15 16 experiments experiment NNS cord-011793-hlktpla4 15 17 , , , cord-011793-hlktpla4 15 18 often often RB cord-011793-hlktpla4 15 19 without without IN cord-011793-hlktpla4 15 20 consent consent NN cord-011793-hlktpla4 15 21 or or CC cord-011793-hlktpla4 15 22 regulatory regulatory JJ cord-011793-hlktpla4 15 23 oversight oversight NN cord-011793-hlktpla4 15 24 , , , cord-011793-hlktpla4 15 25 with with IN cord-011793-hlktpla4 15 26 offlabel offlabel NNP cord-011793-hlktpla4 15 27 uses use VBZ cord-011793-hlktpla4 15 28 of of IN cord-011793-hlktpla4 15 29 already already RB cord-011793-hlktpla4 15 30 - - HYPH cord-011793-hlktpla4 15 31 approved approve VBN cord-011793-hlktpla4 15 32 medications medication NNS cord-011793-hlktpla4 15 33 aimed aim VBN cord-011793-hlktpla4 15 34 at at IN cord-011793-hlktpla4 15 35 treating treat VBG cord-011793-hlktpla4 15 36 some some DT cord-011793-hlktpla4 15 37 mechanistic mechanistic JJ cord-011793-hlktpla4 15 38 pathway pathway NN cord-011793-hlktpla4 15 39 or or CC cord-011793-hlktpla4 15 40 presumed presume VBN cord-011793-hlktpla4 15 41 pathophysiology pathophysiology NN cord-011793-hlktpla4 15 42 extrapolated extrapolate VBN cord-011793-hlktpla4 15 43 from from IN cord-011793-hlktpla4 15 44 a a DT cord-011793-hlktpla4 15 45 limited limited JJ cord-011793-hlktpla4 15 46 number number NN cord-011793-hlktpla4 15 47 of of IN cord-011793-hlktpla4 15 48 these these DT cord-011793-hlktpla4 15 49 patients patient NNS cord-011793-hlktpla4 15 50 . . . cord-011793-hlktpla4 16 1 For for IN cord-011793-hlktpla4 16 2 example example NN cord-011793-hlktpla4 16 3 , , , cord-011793-hlktpla4 16 4 on on IN cord-011793-hlktpla4 16 5 the the DT cord-011793-hlktpla4 16 6 basis basis NN cord-011793-hlktpla4 16 7 of of IN cord-011793-hlktpla4 16 8 a a DT cord-011793-hlktpla4 16 9 case case NN cord-011793-hlktpla4 16 10 series series NN cord-011793-hlktpla4 16 11 of of IN cord-011793-hlktpla4 16 12 21 21 CD cord-011793-hlktpla4 16 13 patients patient NNS cord-011793-hlktpla4 16 14 published publish VBN cord-011793-hlktpla4 16 15 in in IN cord-011793-hlktpla4 16 16 a a DT cord-011793-hlktpla4 16 17 Chinese chinese JJ cord-011793-hlktpla4 16 18 preprint preprint NN cord-011793-hlktpla4 16 19 ( ( -LRB- cord-011793-hlktpla4 16 20 1 1 CD cord-011793-hlktpla4 16 21 ) ) -RRB- cord-011793-hlktpla4 16 22 , , , cord-011793-hlktpla4 16 23 off off IN cord-011793-hlktpla4 16 24 - - HYPH cord-011793-hlktpla4 16 25 label label NN cord-011793-hlktpla4 16 26 use use NN cord-011793-hlktpla4 16 27 of of IN cord-011793-hlktpla4 16 28 the the DT cord-011793-hlktpla4 16 29 interleukin-6 interleukin-6 NNP cord-011793-hlktpla4 16 30 receptor receptor NN cord-011793-hlktpla4 16 31 antagonist antagonist NN cord-011793-hlktpla4 16 32 tocilizumab tocilizumab NNP cord-011793-hlktpla4 16 33 has have VBZ cord-011793-hlktpla4 16 34 been be VBN cord-011793-hlktpla4 16 35 proposed propose VBN cord-011793-hlktpla4 16 36 to to TO cord-011793-hlktpla4 16 37 treat treat VB cord-011793-hlktpla4 16 38 the the DT cord-011793-hlktpla4 16 39 " " `` cord-011793-hlktpla4 16 40 cytokine cytokine NN cord-011793-hlktpla4 16 41 storm storm NN cord-011793-hlktpla4 16 42 " " '' cord-011793-hlktpla4 16 43 that that WDT cord-011793-hlktpla4 16 44 many many JJ cord-011793-hlktpla4 16 45 have have VBP cord-011793-hlktpla4 16 46 postulated postulate VBN cord-011793-hlktpla4 16 47 causes cause VBZ cord-011793-hlktpla4 16 48 the the DT cord-011793-hlktpla4 16 49 multisystem multisystem JJ cord-011793-hlktpla4 16 50 organ organ NN cord-011793-hlktpla4 16 51 dysfunction dysfunction NN cord-011793-hlktpla4 16 52 seen see VBN cord-011793-hlktpla4 16 53 with with IN cord-011793-hlktpla4 16 54 critically critically RB cord-011793-hlktpla4 16 55 ill ill JJ cord-011793-hlktpla4 16 56 patients patient NNS cord-011793-hlktpla4 16 57 with with IN cord-011793-hlktpla4 16 58 COVID-19 COVID-19 NNP cord-011793-hlktpla4 16 59 . . . cord-011793-hlktpla4 17 1 Recently recently RB cord-011793-hlktpla4 17 2 , , , cord-011793-hlktpla4 17 3 off off IN cord-011793-hlktpla4 17 4 - - HYPH cord-011793-hlktpla4 17 5 label label NN cord-011793-hlktpla4 17 6 use use NN cord-011793-hlktpla4 17 7 of of IN cord-011793-hlktpla4 17 8 inhaled inhale VBN cord-011793-hlktpla4 17 9 nitric nitric NN cord-011793-hlktpla4 17 10 oxide oxide NN cord-011793-hlktpla4 17 11 to to TO cord-011793-hlktpla4 17 12 prevent prevent VB cord-011793-hlktpla4 17 13 intubation intubation NN cord-011793-hlktpla4 17 14 and and CC cord-011793-hlktpla4 17 15 empiric empiric JJ cord-011793-hlktpla4 17 16 anticoagulation anticoagulation NN cord-011793-hlktpla4 17 17 or or CC cord-011793-hlktpla4 17 18 thrombolysis thrombolysis NN cord-011793-hlktpla4 17 19 to to TO cord-011793-hlktpla4 17 20 treat treat VB cord-011793-hlktpla4 17 21 the the DT cord-011793-hlktpla4 17 22 microthromboses microthrombose NNS cord-011793-hlktpla4 17 23 seen see VBN cord-011793-hlktpla4 17 24 in in IN cord-011793-hlktpla4 17 25 the the DT cord-011793-hlktpla4 17 26 lungs lung NNS cord-011793-hlktpla4 17 27 on on IN cord-011793-hlktpla4 17 28 autopsy autopsy JJ cord-011793-hlktpla4 17 29 ( ( -LRB- cord-011793-hlktpla4 17 30 2 2 LS cord-011793-hlktpla4 17 31 ) ) -RRB- cord-011793-hlktpla4 17 32 has have VBZ cord-011793-hlktpla4 17 33 also also RB cord-011793-hlktpla4 17 34 been be VBN cord-011793-hlktpla4 17 35 proposed propose VBN cord-011793-hlktpla4 17 36 . . . cord-011793-hlktpla4 18 1 Although although IN cord-011793-hlktpla4 18 2 many many JJ cord-011793-hlktpla4 18 3 effective effective JJ cord-011793-hlktpla4 18 4 treatments treatment NNS cord-011793-hlktpla4 18 5 start start VBP cord-011793-hlktpla4 18 6 with with IN cord-011793-hlktpla4 18 7 similar similar JJ cord-011793-hlktpla4 18 8 postulates postulate NNS cord-011793-hlktpla4 18 9 , , , cord-011793-hlktpla4 18 10 these these DT cord-011793-hlktpla4 18 11 modalities modality NNS cord-011793-hlktpla4 18 12 can can MD cord-011793-hlktpla4 18 13 only only RB cord-011793-hlktpla4 18 14 demonstrate demonstrate VB cord-011793-hlktpla4 18 15 effectiveness effectiveness NN cord-011793-hlktpla4 18 16 , , , cord-011793-hlktpla4 18 17 and and CC cord-011793-hlktpla4 18 18 thus thus RB cord-011793-hlktpla4 18 19 become become VB cord-011793-hlktpla4 18 20 evidencebased evidencebased JJ cord-011793-hlktpla4 18 21 treatments treatment NNS cord-011793-hlktpla4 18 22 , , , cord-011793-hlktpla4 18 23 in in IN cord-011793-hlktpla4 18 24 well well RB cord-011793-hlktpla4 18 25 - - HYPH cord-011793-hlktpla4 18 26 designed design VBN cord-011793-hlktpla4 18 27 , , , cord-011793-hlktpla4 18 28 placebocontrolled placebocontrolled JJ cord-011793-hlktpla4 18 29 randomized randomized JJ cord-011793-hlktpla4 18 30 trials trial NNS cord-011793-hlktpla4 18 31 . . . cord-011793-hlktpla4 19 1 All all RB cord-011793-hlktpla4 19 2 too too RB cord-011793-hlktpla4 19 3 often often RB cord-011793-hlktpla4 19 4 in in IN cord-011793-hlktpla4 19 5 critical critical JJ cord-011793-hlktpla4 19 6 care care NN cord-011793-hlktpla4 19 7 , , , cord-011793-hlktpla4 19 8 hypotheses hypothesis NNS cord-011793-hlktpla4 19 9 based base VBN cord-011793-hlktpla4 19 10 on on IN cord-011793-hlktpla4 19 11 mechanism mechanism NN cord-011793-hlktpla4 19 12 and and CC cord-011793-hlktpla4 19 13 observation observation NN cord-011793-hlktpla4 19 14 failed fail VBD cord-011793-hlktpla4 19 15 the the DT cord-011793-hlktpla4 19 16 test test NN cord-011793-hlktpla4 19 17 of of IN cord-011793-hlktpla4 19 18 the the DT cord-011793-hlktpla4 19 19 randomized randomized JJ cord-011793-hlktpla4 19 20 trial trial NN cord-011793-hlktpla4 19 21 . . . cord-011793-hlktpla4 20 1 The the DT cord-011793-hlktpla4 20 2 arguments argument NNS cord-011793-hlktpla4 20 3 on on IN cord-011793-hlktpla4 20 4 social social JJ cord-011793-hlktpla4 20 5 media medium NNS cord-011793-hlktpla4 20 6 are be VBP cord-011793-hlktpla4 20 7 based base VBN cord-011793-hlktpla4 20 8 more more RBR cord-011793-hlktpla4 20 9 in in IN cord-011793-hlktpla4 20 10 emotion emotion NN cord-011793-hlktpla4 20 11 than than IN cord-011793-hlktpla4 20 12 science science NN cord-011793-hlktpla4 20 13 . . . cord-011793-hlktpla4 21 1 " " `` cord-011793-hlktpla4 21 2 We -PRON- PRP cord-011793-hlktpla4 21 3 can can MD cord-011793-hlktpla4 21 4 not not RB cord-011793-hlktpla4 21 5 just just RB cord-011793-hlktpla4 21 6 do do VB cord-011793-hlktpla4 21 7 nothing nothing NN cord-011793-hlktpla4 21 8 for for IN cord-011793-hlktpla4 21 9 these these DT cord-011793-hlktpla4 21 10 patients patient NNS cord-011793-hlktpla4 21 11 . . . cord-011793-hlktpla4 21 12 " " `` cord-011793-hlktpla4 21 13 As as RB cord-011793-hlktpla4 21 14 much much RB cord-011793-hlktpla4 21 15 as as IN cord-011793-hlktpla4 21 16 the the DT cord-011793-hlktpla4 21 17 " " `` cord-011793-hlktpla4 21 18 do do VBP cord-011793-hlktpla4 21 19 n't not RB cord-011793-hlktpla4 21 20 just just RB cord-011793-hlktpla4 21 21 stand stand VB cord-011793-hlktpla4 21 22 there there RB cord-011793-hlktpla4 21 23 , , , cord-011793-hlktpla4 21 24 do do VB cord-011793-hlktpla4 21 25 something something NN cord-011793-hlktpla4 21 26 " " `` cord-011793-hlktpla4 21 27 feeling feeling NN cord-011793-hlktpla4 21 28 is be VBZ cord-011793-hlktpla4 21 29 real real JJ cord-011793-hlktpla4 21 30 , , , cord-011793-hlktpla4 21 31 it -PRON- PRP cord-011793-hlktpla4 21 32 is be VBZ cord-011793-hlktpla4 21 33 also also RB cord-011793-hlktpla4 21 34 likely likely RB cord-011793-hlktpla4 21 35 dangerous dangerous JJ cord-011793-hlktpla4 21 36 to to IN cord-011793-hlktpla4 21 37 our -PRON- PRP$ cord-011793-hlktpla4 21 38 patients patient NNS cord-011793-hlktpla4 21 39 . . . cord-011793-hlktpla4 22 1 The the DT cord-011793-hlktpla4 22 2 prevailing prevail VBG cord-011793-hlktpla4 22 3 evidence evidence NN cord-011793-hlktpla4 22 4 in in IN cord-011793-hlktpla4 22 5 critical critical JJ cord-011793-hlktpla4 22 6 care care NN cord-011793-hlktpla4 22 7 suggests suggest VBZ cord-011793-hlktpla4 22 8 that that IN cord-011793-hlktpla4 22 9 " " `` cord-011793-hlktpla4 22 10 doing do VBG cord-011793-hlktpla4 22 11 less less RBR cord-011793-hlktpla4 22 12 is be VBZ cord-011793-hlktpla4 22 13 more more JJR cord-011793-hlktpla4 22 14 , , , cord-011793-hlktpla4 22 15 " " '' cord-011793-hlktpla4 22 16 as as IN cord-011793-hlktpla4 22 17 the the DT cord-011793-hlktpla4 22 18 more more RBR cord-011793-hlktpla4 22 19 we -PRON- PRP cord-011793-hlktpla4 22 20 try try VBP cord-011793-hlktpla4 22 21 to to TO cord-011793-hlktpla4 22 22 interfere interfere VB cord-011793-hlktpla4 22 23 or or CC cord-011793-hlktpla4 22 24 disrupt disrupt VB cord-011793-hlktpla4 22 25 the the DT cord-011793-hlktpla4 22 26 pathways pathway NNS cord-011793-hlktpla4 22 27 of of IN cord-011793-hlktpla4 22 28 critical critical JJ cord-011793-hlktpla4 22 29 illness illness NN cord-011793-hlktpla4 22 30 , , , cord-011793-hlktpla4 22 31 the the DT cord-011793-hlktpla4 22 32 worse bad JJR cord-011793-hlktpla4 22 33 the the DT cord-011793-hlktpla4 22 34 patient patient NN cord-011793-hlktpla4 22 35 outcomes outcome NNS cord-011793-hlktpla4 22 36 . . . cord-011793-hlktpla4 23 1 The the DT cord-011793-hlktpla4 23 2 inflammatory inflammatory JJ cord-011793-hlktpla4 23 3 and and CC cord-011793-hlktpla4 23 4 coagulation coagulation NN cord-011793-hlktpla4 23 5 cascades cascade NNS cord-011793-hlktpla4 23 6 of of IN cord-011793-hlktpla4 23 7 critical critical JJ cord-011793-hlktpla4 23 8 illness illness NN cord-011793-hlktpla4 23 9 are be VBP cord-011793-hlktpla4 23 10 intertwined intertwine VBN cord-011793-hlktpla4 23 11 , , , cord-011793-hlktpla4 23 12 complicated complicated JJ cord-011793-hlktpla4 23 13 , , , cord-011793-hlktpla4 23 14 and and CC cord-011793-hlktpla4 23 15 still still RB cord-011793-hlktpla4 23 16 poorly poorly RB cord-011793-hlktpla4 23 17 understood understand VBN cord-011793-hlktpla4 23 18 . . . cord-011793-hlktpla4 24 1 To to TO cord-011793-hlktpla4 24 2 assume assume VB cord-011793-hlktpla4 24 3 that that IN cord-011793-hlktpla4 24 4 we -PRON- PRP cord-011793-hlktpla4 24 5 can can MD cord-011793-hlktpla4 24 6 target target VB cord-011793-hlktpla4 24 7 pathways pathway NNS cord-011793-hlktpla4 24 8 in in IN cord-011793-hlktpla4 24 9 either either DT cord-011793-hlktpla4 24 10 or or CC cord-011793-hlktpla4 24 11 both both DT cord-011793-hlktpla4 24 12 cascades cascade NNS cord-011793-hlktpla4 24 13 and and CC cord-011793-hlktpla4 24 14 improve improve VB cord-011793-hlktpla4 24 15 the the DT cord-011793-hlktpla4 24 16 outcomes outcome NNS cord-011793-hlktpla4 24 17 of of IN cord-011793-hlktpla4 24 18 our -PRON- PRP$ cord-011793-hlktpla4 24 19 patients patient NNS cord-011793-hlktpla4 24 20 is be VBZ cord-011793-hlktpla4 24 21 naive naive JJ cord-011793-hlktpla4 24 22 and and CC cord-011793-hlktpla4 24 23 hubristic hubristic JJ cord-011793-hlktpla4 24 24 , , , cord-011793-hlktpla4 24 25 as as IN cord-011793-hlktpla4 24 26 we -PRON- PRP cord-011793-hlktpla4 24 27 have have VBP cord-011793-hlktpla4 24 28 seen see VBN cord-011793-hlktpla4 24 29 numerous numerous JJ cord-011793-hlktpla4 24 30 times time NNS cord-011793-hlktpla4 24 31 in in IN cord-011793-hlktpla4 24 32 the the DT cord-011793-hlktpla4 24 33 past past NN cord-011793-hlktpla4 24 34 with with IN cord-011793-hlktpla4 24 35 failed fail VBN cord-011793-hlktpla4 24 36 randomized randomized JJ cord-011793-hlktpla4 24 37 trials trial NNS cord-011793-hlktpla4 24 38 of of IN cord-011793-hlktpla4 24 39 antiinflammatory antiinflammatory JJ cord-011793-hlktpla4 24 40 and and CC cord-011793-hlktpla4 24 41 anticoagulant anticoagulant JJ cord-011793-hlktpla4 24 42 agents agent NNS cord-011793-hlktpla4 24 43 , , , cord-011793-hlktpla4 24 44 such such JJ cord-011793-hlktpla4 24 45 as as IN cord-011793-hlktpla4 24 46 anti anti JJ cord-011793-hlktpla4 24 47 - - JJ cord-011793-hlktpla4 24 48 TNF TNF NNP cord-011793-hlktpla4 24 49 ( ( -LRB- cord-011793-hlktpla4 24 50 3 3 CD cord-011793-hlktpla4 24 51 ) ) -RRB- cord-011793-hlktpla4 24 52 , , , cord-011793-hlktpla4 24 53 b b NN cord-011793-hlktpla4 24 54 - - : cord-011793-hlktpla4 24 55 interferon interferon NNP cord-011793-hlktpla4 24 56 ( ( -LRB- cord-011793-hlktpla4 24 57 4 4 CD cord-011793-hlktpla4 24 58 ) ) -RRB- cord-011793-hlktpla4 24 59 , , , cord-011793-hlktpla4 24 60 recombinant recombinant JJ cord-011793-hlktpla4 24 61 human human NN cord-011793-hlktpla4 24 62 activated activate VBN cord-011793-hlktpla4 24 63 protein protein NN cord-011793-hlktpla4 24 64 C C NNP cord-011793-hlktpla4 24 65 ( ( -LRB- cord-011793-hlktpla4 24 66 5 5 CD cord-011793-hlktpla4 24 67 ) ) -RRB- cord-011793-hlktpla4 24 68 , , , cord-011793-hlktpla4 24 69 and and CC cord-011793-hlktpla4 24 70 statins statin NNS cord-011793-hlktpla4 24 71 ( ( -LRB- cord-011793-hlktpla4 24 72 6 6 CD cord-011793-hlktpla4 24 73 ) ) -RRB- cord-011793-hlktpla4 24 74 . . . cord-011793-hlktpla4 25 1 Novel novel JJ cord-011793-hlktpla4 25 2 treatments treatment NNS cord-011793-hlktpla4 25 3 must must MD cord-011793-hlktpla4 25 4 be be VB cord-011793-hlktpla4 25 5 studied study VBN cord-011793-hlktpla4 25 6 in in IN cord-011793-hlktpla4 25 7 randomized randomized JJ cord-011793-hlktpla4 25 8 controlled control VBN cord-011793-hlktpla4 25 9 trials trial NNS cord-011793-hlktpla4 25 10 to to TO cord-011793-hlktpla4 25 11 truly truly RB cord-011793-hlktpla4 25 12 understand understand VB cord-011793-hlktpla4 25 13 both both CC cord-011793-hlktpla4 25 14 their -PRON- PRP$ cord-011793-hlktpla4 25 15 benefits benefit NNS cord-011793-hlktpla4 25 16 and and CC cord-011793-hlktpla4 25 17 their -PRON- PRP$ cord-011793-hlktpla4 25 18 risks risk NNS cord-011793-hlktpla4 25 19 ( ( -LRB- cord-011793-hlktpla4 25 20 7 7 CD cord-011793-hlktpla4 25 21 ) ) -RRB- cord-011793-hlktpla4 25 22 , , , cord-011793-hlktpla4 25 23 especially especially RB cord-011793-hlktpla4 25 24 because because IN cord-011793-hlktpla4 25 25 recent recent JJ cord-011793-hlktpla4 25 26 data datum NNS cord-011793-hlktpla4 25 27 suggest suggest VBP cord-011793-hlktpla4 25 28 about about IN cord-011793-hlktpla4 25 29 95 95 CD cord-011793-hlktpla4 25 30 % % NN cord-011793-hlktpla4 25 31 of of IN cord-011793-hlktpla4 25 32 critical critical JJ cord-011793-hlktpla4 25 33 care care NN cord-011793-hlktpla4 25 34 trials trial NNS cord-011793-hlktpla4 25 35 fail fail VBP cord-011793-hlktpla4 25 36 to to TO cord-011793-hlktpla4 25 37 demonstrate demonstrate VB cord-011793-hlktpla4 25 38 benefit benefit NN cord-011793-hlktpla4 25 39 ( ( -LRB- cord-011793-hlktpla4 25 40 8) 8) NN cord-011793-hlktpla4 25 41 , , , cord-011793-hlktpla4 25 42 rendering render VBG cord-011793-hlktpla4 25 43 the the DT cord-011793-hlktpla4 25 44 pretest pretest NN cord-011793-hlktpla4 25 45 probability probability NN cord-011793-hlktpla4 25 46 very very RB cord-011793-hlktpla4 25 47 low low JJ cord-011793-hlktpla4 25 48 . . . cord-011793-hlktpla4 26 1 Yet yet RB cord-011793-hlktpla4 26 2 many many JJ cord-011793-hlktpla4 26 3 of of IN cord-011793-hlktpla4 26 4 the the DT cord-011793-hlktpla4 26 5 past past JJ cord-011793-hlktpla4 26 6 30 30 CD cord-011793-hlktpla4 26 7 years year NNS cord-011793-hlktpla4 26 8 of of IN cord-011793-hlktpla4 26 9 failed fail VBN cord-011793-hlktpla4 26 10 critical critical JJ cord-011793-hlktpla4 26 11 care care NN cord-011793-hlktpla4 26 12 research research NN cord-011793-hlktpla4 26 13 hypotheses hypothesis NNS cord-011793-hlktpla4 26 14 have have VBP cord-011793-hlktpla4 26 15 been be VBN cord-011793-hlktpla4 26 16 resurrected resurrect VBN cord-011793-hlktpla4 26 17 in in IN cord-011793-hlktpla4 26 18 hopes hope NNS cord-011793-hlktpla4 26 19 of of IN cord-011793-hlktpla4 26 20 providing provide VBG cord-011793-hlktpla4 26 21 novel novel JJ cord-011793-hlktpla4 26 22 COVID-19 covid-19 CD cord-011793-hlktpla4 26 23 treatments treatment NNS cord-011793-hlktpla4 26 24 . . . cord-011793-hlktpla4 27 1 Although although IN cord-011793-hlktpla4 27 2 the the DT cord-011793-hlktpla4 27 3 desire desire NN cord-011793-hlktpla4 27 4 to to TO cord-011793-hlktpla4 27 5 try try VB cord-011793-hlktpla4 27 6 to to TO cord-011793-hlktpla4 27 7 treat treat VB cord-011793-hlktpla4 27 8 these these DT cord-011793-hlktpla4 27 9 patients patient NNS cord-011793-hlktpla4 27 10 with with IN cord-011793-hlktpla4 27 11 already already RB cord-011793-hlktpla4 27 12 approved approve VBN cord-011793-hlktpla4 27 13 drugs drug NNS cord-011793-hlktpla4 27 14 is be VBZ cord-011793-hlktpla4 27 15 understandable understandable JJ cord-011793-hlktpla4 27 16 , , , cord-011793-hlktpla4 27 17 what what WP cord-011793-hlktpla4 27 18 is be VBZ cord-011793-hlktpla4 27 19 less less RBR cord-011793-hlktpla4 27 20 understandable understandable JJ cord-011793-hlktpla4 27 21 is be VBZ cord-011793-hlktpla4 27 22 the the DT cord-011793-hlktpla4 27 23 desire desire NN cord-011793-hlktpla4 27 24 in in IN cord-011793-hlktpla4 27 25 medical medical JJ cord-011793-hlktpla4 27 26 publications publication NNS cord-011793-hlktpla4 27 27 and and CC cord-011793-hlktpla4 27 28 on on IN cord-011793-hlktpla4 27 29 social social JJ cord-011793-hlktpla4 27 30 media medium NNS cord-011793-hlktpla4 27 31 to to TO cord-011793-hlktpla4 27 32 abandon abandon VB cord-011793-hlktpla4 27 33 the the DT cord-011793-hlktpla4 27 34 principles principle NNS cord-011793-hlktpla4 27 35 of of IN cord-011793-hlktpla4 27 36 evidence evidence NN cord-011793-hlktpla4 27 37 - - HYPH cord-011793-hlktpla4 27 38 based base VBN cord-011793-hlktpla4 27 39 critical critical JJ cord-011793-hlktpla4 27 40 care care NN cord-011793-hlktpla4 27 41 that that WDT cord-011793-hlktpla4 27 42 we -PRON- PRP cord-011793-hlktpla4 27 43 have have VBP cord-011793-hlktpla4 27 44 established establish VBN cord-011793-hlktpla4 27 45 over over IN cord-011793-hlktpla4 27 46 the the DT cord-011793-hlktpla4 27 47 last last JJ cord-011793-hlktpla4 27 48 3 3 CD cord-011793-hlktpla4 27 49 decades decade NNS cord-011793-hlktpla4 27 50 ( ( -LRB- cord-011793-hlktpla4 27 51 9 9 CD cord-011793-hlktpla4 27 52 ) ) -RRB- cord-011793-hlktpla4 27 53 , , , cord-011793-hlktpla4 27 54 because because IN cord-011793-hlktpla4 27 55 " " `` cord-011793-hlktpla4 27 56 I -PRON- PRP cord-011793-hlktpla4 27 57 have have VBP cord-011793-hlktpla4 27 58 never never RB cord-011793-hlktpla4 27 59 seen see VBN cord-011793-hlktpla4 27 60 patients patient NNS cord-011793-hlktpla4 27 61 with with IN cord-011793-hlktpla4 27 62 ARDS ARDS NNP cord-011793-hlktpla4 27 63 act act VBP cord-011793-hlktpla4 27 64 like like IN cord-011793-hlktpla4 27 65 this this DT cord-011793-hlktpla4 27 66 . . . cord-011793-hlktpla4 28 1 " " '' cord-011793-hlktpla4 29 1 Large large JJ cord-011793-hlktpla4 29 2 , , , cord-011793-hlktpla4 29 3 well well RB cord-011793-hlktpla4 29 4 - - HYPH cord-011793-hlktpla4 29 5 designed design VBN cord-011793-hlktpla4 29 6 , , , cord-011793-hlktpla4 29 7 multicenter multicenter JJ cord-011793-hlktpla4 29 8 randomized randomized JJ cord-011793-hlktpla4 29 9 trials trial NNS cord-011793-hlktpla4 29 10 have have VBP cord-011793-hlktpla4 29 11 set set VBN cord-011793-hlktpla4 29 12 the the DT cord-011793-hlktpla4 29 13 foundation foundation NN cord-011793-hlktpla4 29 14 of of IN cord-011793-hlktpla4 29 15 an an DT cord-011793-hlktpla4 29 16 evidence evidence NN cord-011793-hlktpla4 29 17 - - HYPH cord-011793-hlktpla4 29 18 based base VBN cord-011793-hlktpla4 29 19 practice practice NN cord-011793-hlktpla4 29 20 of of IN cord-011793-hlktpla4 29 21 how how WRB cord-011793-hlktpla4 29 22 to to TO cord-011793-hlktpla4 29 23 produce produce VB cord-011793-hlktpla4 29 24 the the DT cord-011793-hlktpla4 29 25 best good JJS cord-011793-hlktpla4 29 26 outcomes outcome NNS cord-011793-hlktpla4 29 27 for for IN cord-011793-hlktpla4 29 28 critically critically RB cord-011793-hlktpla4 29 29 ill ill JJ cord-011793-hlktpla4 29 30 patients patient NNS cord-011793-hlktpla4 29 31 . . . cord-011793-hlktpla4 30 1 Abandonment abandonment NN cord-011793-hlktpla4 30 2 of of IN cord-011793-hlktpla4 30 3 these these DT cord-011793-hlktpla4 30 4 principles principle NNS cord-011793-hlktpla4 30 5 in in IN cord-011793-hlktpla4 30 6 the the DT cord-011793-hlktpla4 30 7 face face NN cord-011793-hlktpla4 30 8 of of IN cord-011793-hlktpla4 30 9 this this DT cord-011793-hlktpla4 30 10 pandemic pandemic NN cord-011793-hlktpla4 30 11 , , , cord-011793-hlktpla4 30 12 without without IN cord-011793-hlktpla4 30 13 any any DT cord-011793-hlktpla4 30 14 supporting support VBG cord-011793-hlktpla4 30 15 scientific scientific JJ cord-011793-hlktpla4 30 16 data datum NNS cord-011793-hlktpla4 30 17 , , , cord-011793-hlktpla4 30 18 simply simply RB cord-011793-hlktpla4 30 19 because because IN cord-011793-hlktpla4 30 20 we -PRON- PRP cord-011793-hlktpla4 30 21 are be VBP cord-011793-hlktpla4 30 22 scared scared JJ cord-011793-hlktpla4 30 23 or or CC cord-011793-hlktpla4 30 24 overwhelmed overwhelmed JJ cord-011793-hlktpla4 30 25 , , , cord-011793-hlktpla4 30 26 because because IN cord-011793-hlktpla4 30 27 we -PRON- PRP cord-011793-hlktpla4 30 28 believe believe VBP cord-011793-hlktpla4 30 29 after after IN cord-011793-hlktpla4 30 30 a a DT cord-011793-hlktpla4 30 31 few few JJ cord-011793-hlktpla4 30 32 months month NNS cord-011793-hlktpla4 30 33 of of IN cord-011793-hlktpla4 30 34 anecdotal anecdotal JJ cord-011793-hlktpla4 30 35 experience experience NN cord-011793-hlktpla4 30 36 that that WDT cord-011793-hlktpla4 30 37 we -PRON- PRP cord-011793-hlktpla4 30 38 have have VBP cord-011793-hlktpla4 30 39 recognized recognize VBN cord-011793-hlktpla4 30 40 an an DT cord-011793-hlktpla4 30 41 entirely entirely RB cord-011793-hlktpla4 30 42 unique unique JJ cord-011793-hlktpla4 30 43 syndrome syndrome NN cord-011793-hlktpla4 30 44 , , , cord-011793-hlktpla4 30 45 or or CC cord-011793-hlktpla4 30 46 because because IN cord-011793-hlktpla4 30 47 we -PRON- PRP cord-011793-hlktpla4 30 48 have have VBP cord-011793-hlktpla4 30 49 not not RB cord-011793-hlktpla4 30 50 had have VBN cord-011793-hlktpla4 30 51 time time NN cord-011793-hlktpla4 30 52 to to TO cord-011793-hlktpla4 30 53 conduct conduct VB cord-011793-hlktpla4 30 54 randomized randomize VBN cord-011793-hlktpla4 30 55 controlled control VBN cord-011793-hlktpla4 30 56 trials trial NNS cord-011793-hlktpla4 30 57 specifically specifically RB cord-011793-hlktpla4 30 58 in in IN cord-011793-hlktpla4 30 59 these these DT cord-011793-hlktpla4 30 60 patients patient NNS cord-011793-hlktpla4 30 61 , , , cord-011793-hlktpla4 30 62 is be VBZ cord-011793-hlktpla4 30 63 clearly clearly RB cord-011793-hlktpla4 30 64 unacceptable unacceptable JJ cord-011793-hlktpla4 30 65 . . . cord-011793-hlktpla4 31 1 Outcomes outcome NNS cord-011793-hlktpla4 31 2 of of IN cord-011793-hlktpla4 31 3 critically critically RB cord-011793-hlktpla4 31 4 ill ill JJ cord-011793-hlktpla4 31 5 patients patient NNS cord-011793-hlktpla4 31 6 have have VBP cord-011793-hlktpla4 31 7 improved improve VBN cord-011793-hlktpla4 31 8 steadily steadily RB cord-011793-hlktpla4 31 9 over over IN cord-011793-hlktpla4 31 10 the the DT cord-011793-hlktpla4 31 11 last last JJ cord-011793-hlktpla4 31 12 3 3 CD cord-011793-hlktpla4 31 13 decades decade NNS cord-011793-hlktpla4 31 14 , , , cord-011793-hlktpla4 31 15 not not RB cord-011793-hlktpla4 31 16 through through IN cord-011793-hlktpla4 31 17 the the DT cord-011793-hlktpla4 31 18 approval approval NN cord-011793-hlktpla4 31 19 of of IN cord-011793-hlktpla4 31 20 new new JJ cord-011793-hlktpla4 31 21 pharmacologic pharmacologic JJ cord-011793-hlktpla4 31 22 agents agent NNS cord-011793-hlktpla4 31 23 or or CC cord-011793-hlktpla4 31 24 by by IN cord-011793-hlktpla4 31 25 discovering discover VBG cord-011793-hlktpla4 31 26 some some DT cord-011793-hlktpla4 31 27 unique unique JJ cord-011793-hlktpla4 31 28 physiology physiology NN cord-011793-hlktpla4 31 29 in in IN cord-011793-hlktpla4 31 30 a a DT cord-011793-hlktpla4 31 31 new new JJ cord-011793-hlktpla4 31 32 disease disease NN cord-011793-hlktpla4 31 33 . . . cord-011793-hlktpla4 32 1 Instead instead RB cord-011793-hlktpla4 32 2 , , , cord-011793-hlktpla4 32 3 improved improved JJ cord-011793-hlktpla4 32 4 outcomes outcome NNS cord-011793-hlktpla4 32 5 are be VBP cord-011793-hlktpla4 32 6 seen see VBN cord-011793-hlktpla4 32 7 through through IN cord-011793-hlktpla4 32 8 understanding understanding NN cord-011793-hlktpla4 32 9 and and CC cord-011793-hlktpla4 32 10 implementing implement VBG cord-011793-hlktpla4 32 11 best good JJS cord-011793-hlktpla4 32 12 practices practice NNS cord-011793-hlktpla4 32 13 derived derive VBN cord-011793-hlktpla4 32 14 via via IN cord-011793-hlktpla4 32 15 strong strong JJ cord-011793-hlktpla4 32 16 scientific scientific JJ cord-011793-hlktpla4 32 17 evidence evidence NN cord-011793-hlktpla4 32 18 generated generate VBN cord-011793-hlktpla4 32 19 from from IN cord-011793-hlktpla4 32 20 well well RB cord-011793-hlktpla4 32 21 - - HYPH cord-011793-hlktpla4 32 22 designed design VBN cord-011793-hlktpla4 32 23 randomized randomized JJ cord-011793-hlktpla4 32 24 controlled control VBN cord-011793-hlktpla4 32 25 trials trial NNS cord-011793-hlktpla4 32 26 into into IN cord-011793-hlktpla4 32 27 the the DT cord-011793-hlktpla4 32 28 routine routine JJ cord-011793-hlktpla4 32 29 care care NN cord-011793-hlktpla4 32 30 of of IN cord-011793-hlktpla4 32 31 critically critically RB cord-011793-hlktpla4 32 32 ill ill JJ cord-011793-hlktpla4 32 33 patients patient NNS cord-011793-hlktpla4 32 34 . . . cord-011793-hlktpla4 33 1 In in IN cord-011793-hlktpla4 33 2 other other JJ cord-011793-hlktpla4 33 3 words word NNS cord-011793-hlktpla4 33 4 , , , cord-011793-hlktpla4 33 5 doing do VBG cord-011793-hlktpla4 33 6 the the DT cord-011793-hlktpla4 33 7 things thing NNS cord-011793-hlktpla4 33 8 we -PRON- PRP cord-011793-hlktpla4 33 9 do do VBP cord-011793-hlktpla4 33 10 , , , cord-011793-hlktpla4 33 11 and and CC cord-011793-hlktpla4 33 12 doing do VBG cord-011793-hlktpla4 33 13 them -PRON- PRP cord-011793-hlktpla4 33 14 well well RB cord-011793-hlktpla4 33 15 . . . cord-011793-hlktpla4 34 1 Lung lung NN cord-011793-hlktpla4 34 2 - - HYPH cord-011793-hlktpla4 34 3 protective protective JJ cord-011793-hlktpla4 34 4 ventilation ventilation NN cord-011793-hlktpla4 34 5 with with IN cord-011793-hlktpla4 34 6 lower low JJR cord-011793-hlktpla4 34 7 tidal tidal JJ cord-011793-hlktpla4 34 8 volumes volume NNS cord-011793-hlktpla4 34 9 reduces reduce VBZ cord-011793-hlktpla4 34 10 mortality mortality NN cord-011793-hlktpla4 34 11 and and CC cord-011793-hlktpla4 34 12 shortens shorten VBZ cord-011793-hlktpla4 34 13 duration duration NN cord-011793-hlktpla4 34 14 of of IN cord-011793-hlktpla4 34 15 ventilation ventilation NN cord-011793-hlktpla4 34 16 in in IN cord-011793-hlktpla4 34 17 patients patient NNS cord-011793-hlktpla4 34 18 with with IN cord-011793-hlktpla4 34 19 ARDS ARDS NNP cord-011793-hlktpla4 34 20 ( ( -LRB- cord-011793-hlktpla4 34 21 10 10 CD cord-011793-hlktpla4 34 22 ) ) -RRB- cord-011793-hlktpla4 34 23 , , , cord-011793-hlktpla4 34 24 even even RB cord-011793-hlktpla4 34 25 those those DT cord-011793-hlktpla4 34 26 who who WP cord-011793-hlktpla4 34 27 have have VBP cord-011793-hlktpla4 34 28 relatively relatively RB cord-011793-hlktpla4 34 29 preserved preserve VBN cord-011793-hlktpla4 34 30 compliance compliance NN cord-011793-hlktpla4 34 31 ( ( -LRB- cord-011793-hlktpla4 34 32 11 11 CD cord-011793-hlktpla4 34 33 ) ) -RRB- cord-011793-hlktpla4 34 34 , , , cord-011793-hlktpla4 34 35 like like IN cord-011793-hlktpla4 34 36 that that DT cord-011793-hlktpla4 34 37 being be VBG cord-011793-hlktpla4 34 38 seen see VBN cord-011793-hlktpla4 34 39 early early RB cord-011793-hlktpla4 34 40 in in IN cord-011793-hlktpla4 34 41 the the DT cord-011793-hlktpla4 34 42 ARDS ARDS NNP cord-011793-hlktpla4 34 43 course course NN cord-011793-hlktpla4 34 44 of of IN cord-011793-hlktpla4 34 45 patients patient NNS cord-011793-hlktpla4 34 46 with with IN cord-011793-hlktpla4 34 47 COVID-19 COVID-19 NNP cord-011793-hlktpla4 34 48 . . . cord-011793-hlktpla4 35 1 In in IN cord-011793-hlktpla4 35 2 addition addition NN cord-011793-hlktpla4 35 3 , , , cord-011793-hlktpla4 35 4 randomized randomized JJ cord-011793-hlktpla4 35 5 trials trial NNS cord-011793-hlktpla4 35 6 in in IN cord-011793-hlktpla4 35 7 ventilated ventilate VBN cord-011793-hlktpla4 35 8 patients patient NNS cord-011793-hlktpla4 35 9 without without IN cord-011793-hlktpla4 35 10 ARDS ARDS NNP cord-011793-hlktpla4 35 11 have have VBP cord-011793-hlktpla4 35 12 also also RB cord-011793-hlktpla4 35 13 demonstrated demonstrate VBN cord-011793-hlktpla4 35 14 improved improve VBN cord-011793-hlktpla4 35 15 outcomes outcome NNS cord-011793-hlktpla4 35 16 with with IN cord-011793-hlktpla4 35 17 similar similar JJ cord-011793-hlktpla4 35 18 lungprotective lungprotective JJ cord-011793-hlktpla4 35 19 ventilation ventilation NN cord-011793-hlktpla4 35 20 strategies strategy NNS cord-011793-hlktpla4 35 21 using use VBG cord-011793-hlktpla4 35 22 tidal tidal JJ cord-011793-hlktpla4 35 23 volumes volume NNS cord-011793-hlktpla4 35 24 around around IN cord-011793-hlktpla4 35 25 6 6 CD cord-011793-hlktpla4 35 26 ml ml NNS cord-011793-hlktpla4 35 27 / / SYM cord-011793-hlktpla4 35 28 kg kg NNS cord-011793-hlktpla4 35 29 predicted predict VBD cord-011793-hlktpla4 35 30 body body NN cord-011793-hlktpla4 35 31 weight weight NN cord-011793-hlktpla4 35 32 ( ( -LRB- cord-011793-hlktpla4 35 33 12 12 CD cord-011793-hlktpla4 35 34 ) ) -RRB- cord-011793-hlktpla4 35 35 . . . cord-011793-hlktpla4 36 1 Studies study NNS cord-011793-hlktpla4 36 2 demonstrating demonstrate VBG cord-011793-hlktpla4 36 3 benefit benefit NN cord-011793-hlktpla4 36 4 from from IN cord-011793-hlktpla4 36 5 higher high JJR cord-011793-hlktpla4 36 6 tidal tidal JJ cord-011793-hlktpla4 36 7 volumes volume NNS cord-011793-hlktpla4 36 8 in in IN cord-011793-hlktpla4 36 9 patients patient NNS cord-011793-hlktpla4 36 10 with with IN cord-011793-hlktpla4 36 11 higher high JJR cord-011793-hlktpla4 36 12 compliance compliance NN cord-011793-hlktpla4 36 13 are be VBP cord-011793-hlktpla4 36 14 nonexistent nonexistent JJ cord-011793-hlktpla4 36 15 , , , cord-011793-hlktpla4 36 16 and and CC cord-011793-hlktpla4 36 17 to to TO cord-011793-hlktpla4 36 18 think think VB cord-011793-hlktpla4 36 19 that that IN cord-011793-hlktpla4 36 20 after after IN cord-011793-hlktpla4 36 21 a a DT cord-011793-hlktpla4 36 22 few few JJ cord-011793-hlktpla4 36 23 months month NNS cord-011793-hlktpla4 36 24 of of IN cord-011793-hlktpla4 36 25 experience experience NN cord-011793-hlktpla4 36 26 we -PRON- PRP cord-011793-hlktpla4 36 27 have have VBP cord-011793-hlktpla4 36 28 found find VBN cord-011793-hlktpla4 36 29 a a DT cord-011793-hlktpla4 36 30 special special JJ cord-011793-hlktpla4 36 31 population population NN cord-011793-hlktpla4 36 32 that that WDT cord-011793-hlktpla4 36 33 we -PRON- PRP cord-011793-hlktpla4 36 34 should should MD cord-011793-hlktpla4 36 35 ventilate ventilate VB cord-011793-hlktpla4 36 36 differently differently RB cord-011793-hlktpla4 36 37 than than IN cord-011793-hlktpla4 36 38 all all DT cord-011793-hlktpla4 36 39 others other NNS cord-011793-hlktpla4 36 40 seems seem VBZ cord-011793-hlktpla4 36 41 nonsensical nonsensical JJ cord-011793-hlktpla4 36 42 . . . cord-011793-hlktpla4 37 1 Similarly similarly RB cord-011793-hlktpla4 37 2 , , , cord-011793-hlktpla4 37 3 higher high JJR cord-011793-hlktpla4 37 4 levels level NNS cord-011793-hlktpla4 37 5 of of IN cord-011793-hlktpla4 37 6 positive positive JJ cord-011793-hlktpla4 37 7 end end NN cord-011793-hlktpla4 37 8 - - HYPH cord-011793-hlktpla4 37 9 expiratory expiratory NN cord-011793-hlktpla4 37 10 pressure pressure NN cord-011793-hlktpla4 37 11 ( ( -LRB- cord-011793-hlktpla4 37 12 PEEP peep NN cord-011793-hlktpla4 37 13 ) ) -RRB- cord-011793-hlktpla4 37 14 ( ( -LRB- cord-011793-hlktpla4 37 15 13 13 CD cord-011793-hlktpla4 37 16 ) ) -RRB- cord-011793-hlktpla4 37 17 and and CC cord-011793-hlktpla4 37 18 prone prone JJ cord-011793-hlktpla4 37 19 positioning positioning NN cord-011793-hlktpla4 37 20 ( ( -LRB- cord-011793-hlktpla4 37 21 14 14 CD cord-011793-hlktpla4 37 22 ) ) -RRB- cord-011793-hlktpla4 37 23 have have VBP cord-011793-hlktpla4 37 24 both both DT cord-011793-hlktpla4 37 25 been be VBN cord-011793-hlktpla4 37 26 demonstrated demonstrate VBN cord-011793-hlktpla4 37 27 to to TO cord-011793-hlktpla4 37 28 improve improve VB cord-011793-hlktpla4 37 29 mortality mortality NN cord-011793-hlktpla4 37 30 in in IN cord-011793-hlktpla4 37 31 patients patient NNS cord-011793-hlktpla4 37 32 with with IN cord-011793-hlktpla4 37 33 severe severe JJ cord-011793-hlktpla4 37 34 ARDS ARDS NNP cord-011793-hlktpla4 37 35 , , , cord-011793-hlktpla4 37 36 as as IN cord-011793-hlktpla4 37 37 defined define VBN cord-011793-hlktpla4 37 38 by by IN cord-011793-hlktpla4 37 39 oxygenation oxygenation NN cord-011793-hlktpla4 37 40 and and CC cord-011793-hlktpla4 37 41 not not RB cord-011793-hlktpla4 37 42 lung lung NN cord-011793-hlktpla4 37 43 compliance compliance NN cord-011793-hlktpla4 37 44 . . . cord-011793-hlktpla4 38 1 Maintaining maintain VBG cord-011793-hlktpla4 38 2 other other JJ cord-011793-hlktpla4 38 3 principles principle NNS cord-011793-hlktpla4 38 4 of of IN cord-011793-hlktpla4 38 5 good good JJ cord-011793-hlktpla4 38 6 critical critical JJ cord-011793-hlktpla4 38 7 care care NN cord-011793-hlktpla4 38 8 , , , cord-011793-hlktpla4 38 9 as as IN cord-011793-hlktpla4 38 10 demonstrated demonstrate VBN cord-011793-hlktpla4 38 11 in in IN cord-011793-hlktpla4 38 12 large large JJ cord-011793-hlktpla4 38 13 , , , cord-011793-hlktpla4 38 14 multicenter multicenter JJ cord-011793-hlktpla4 38 15 randomized randomized JJ cord-011793-hlktpla4 38 16 trials trial NNS cord-011793-hlktpla4 38 17 , , , cord-011793-hlktpla4 38 18 will will MD cord-011793-hlktpla4 38 19 also also RB cord-011793-hlktpla4 38 20 improve improve VB cord-011793-hlktpla4 38 21 outcomes outcome NNS cord-011793-hlktpla4 38 22 in in IN cord-011793-hlktpla4 38 23 these these DT cord-011793-hlktpla4 38 24 critically critically RB cord-011793-hlktpla4 38 25 ill ill JJ cord-011793-hlktpla4 38 26 patients patient NNS cord-011793-hlktpla4 38 27 with with IN cord-011793-hlktpla4 38 28 COVID-19 COVID-19 NNP cord-011793-hlktpla4 38 29 , , , cord-011793-hlktpla4 38 30 even even RB cord-011793-hlktpla4 38 31 if if IN cord-011793-hlktpla4 38 32 " " `` cord-011793-hlktpla4 38 33 COVID-19 COVID-19 NNP cord-011793-hlktpla4 38 34 is be VBZ cord-011793-hlktpla4 38 35 completely completely RB cord-011793-hlktpla4 38 36 different different JJ cord-011793-hlktpla4 38 37 from from IN cord-011793-hlktpla4 38 38 other other JJ cord-011793-hlktpla4 38 39 intensive intensive JJ cord-011793-hlktpla4 38 40 care care NN cord-011793-hlktpla4 38 41 unit unit NN cord-011793-hlktpla4 38 42 syndromes syndrome NNS cord-011793-hlktpla4 38 43 . . . cord-011793-hlktpla4 39 1 " " `` cord-011793-hlktpla4 39 2 Conservative conservative JJ cord-011793-hlktpla4 39 3 fluid fluid JJ cord-011793-hlktpla4 39 4 management management NN cord-011793-hlktpla4 39 5 once once RB cord-011793-hlktpla4 39 6 out out IN cord-011793-hlktpla4 39 7 of of IN cord-011793-hlktpla4 39 8 shock shock NN cord-011793-hlktpla4 39 9 and and CC cord-011793-hlktpla4 39 10 without without IN cord-011793-hlktpla4 39 11 renal renal JJ cord-011793-hlktpla4 39 12 failure failure NN cord-011793-hlktpla4 39 13 increases increase VBZ cord-011793-hlktpla4 39 14 time time NN cord-011793-hlktpla4 39 15 alive alive JJ cord-011793-hlktpla4 39 16 and and CC cord-011793-hlktpla4 39 17 free free JJ cord-011793-hlktpla4 39 18 from from IN cord-011793-hlktpla4 39 19 ventilation ventilation NN cord-011793-hlktpla4 39 20 ( ( -LRB- cord-011793-hlktpla4 39 21 15 15 CD cord-011793-hlktpla4 39 22 ) ) -RRB- cord-011793-hlktpla4 39 23 . . . cord-011793-hlktpla4 40 1 Although although IN cord-011793-hlktpla4 40 2 frequently frequently RB cord-011793-hlktpla4 40 3 more more RBR cord-011793-hlktpla4 40 4 difficult difficult JJ cord-011793-hlktpla4 40 5 in in IN cord-011793-hlktpla4 40 6 these these DT cord-011793-hlktpla4 40 7 patients patient NNS cord-011793-hlktpla4 40 8 , , , cord-011793-hlktpla4 40 9 concurrently concurrently RB cord-011793-hlktpla4 40 10 timed time VBN cord-011793-hlktpla4 40 11 daily daily JJ cord-011793-hlktpla4 40 12 awakening awakening NN cord-011793-hlktpla4 40 13 and and CC cord-011793-hlktpla4 40 14 spontaneous spontaneous JJ cord-011793-hlktpla4 40 15 breathing breathing NN cord-011793-hlktpla4 40 16 trials trial NNS cord-011793-hlktpla4 40 17 , , , cord-011793-hlktpla4 40 18 with with IN cord-011793-hlktpla4 40 19 close close JJ cord-011793-hlktpla4 40 20 monitoring monitoring NN cord-011793-hlktpla4 40 21 at at IN cord-011793-hlktpla4 40 22 the the DT cord-011793-hlktpla4 40 23 patients patient NNS cord-011793-hlktpla4 40 24 ' ' POS cord-011793-hlktpla4 40 25 bedside bedside NN cord-011793-hlktpla4 40 26 and and CC cord-011793-hlktpla4 40 27 efficient efficient JJ cord-011793-hlktpla4 40 28 extubation extubation NN cord-011793-hlktpla4 40 29 after after IN cord-011793-hlktpla4 40 30 30 30 CD cord-011793-hlktpla4 40 31 minutes minute NNS cord-011793-hlktpla4 40 32 , , , cord-011793-hlktpla4 40 33 sometimes sometimes RB cord-011793-hlktpla4 40 34 using use VBG cord-011793-hlktpla4 40 35 low low JJ cord-011793-hlktpla4 40 36 - - HYPH cord-011793-hlktpla4 40 37 dose dose NN cord-011793-hlktpla4 40 38 dexmedetomidine dexmedetomidine NN cord-011793-hlktpla4 40 39 , , , cord-011793-hlktpla4 40 40 can can MD cord-011793-hlktpla4 40 41 successfully successfully RB cord-011793-hlktpla4 40 42 liberate liberate VB cord-011793-hlktpla4 40 43 these these DT cord-011793-hlktpla4 40 44 patients patient NNS cord-011793-hlktpla4 40 45 from from IN cord-011793-hlktpla4 40 46 the the DT cord-011793-hlktpla4 40 47 ventilator ventilator NN cord-011793-hlktpla4 40 48 faster fast RBR cord-011793-hlktpla4 40 49 ( ( -LRB- cord-011793-hlktpla4 40 50 16 16 CD cord-011793-hlktpla4 40 51 ) ) -RRB- cord-011793-hlktpla4 40 52 , , , cord-011793-hlktpla4 40 53 making make VBG cord-011793-hlktpla4 40 54 that that DT cord-011793-hlktpla4 40 55 ventilator ventilator NN cord-011793-hlktpla4 40 56 available available JJ cord-011793-hlktpla4 40 57 for for IN cord-011793-hlktpla4 40 58 the the DT cord-011793-hlktpla4 40 59 next next JJ cord-011793-hlktpla4 40 60 critically critically RB cord-011793-hlktpla4 40 61 ill ill JJ cord-011793-hlktpla4 40 62 patient patient NN cord-011793-hlktpla4 40 63 . . . cord-011793-hlktpla4 41 1 Checklists checklist NNS cord-011793-hlktpla4 41 2 for for IN cord-011793-hlktpla4 41 3 placement placement NN cord-011793-hlktpla4 41 4 of of IN cord-011793-hlktpla4 41 5 central central JJ cord-011793-hlktpla4 41 6 lines line NNS cord-011793-hlktpla4 41 7 ( ( -LRB- cord-011793-hlktpla4 41 8 17 17 CD cord-011793-hlktpla4 41 9 ) ) -RRB- cord-011793-hlktpla4 41 10 and and CC cord-011793-hlktpla4 41 11 other other JJ cord-011793-hlktpla4 41 12 infection infection NN cord-011793-hlktpla4 41 13 prevention prevention NN cord-011793-hlktpla4 41 14 strategies strategy NNS cord-011793-hlktpla4 41 15 will will MD cord-011793-hlktpla4 41 16 decrease decrease VB cord-011793-hlktpla4 41 17 health health NN cord-011793-hlktpla4 41 18 care care NN cord-011793-hlktpla4 41 19 - - HYPH cord-011793-hlktpla4 41 20 acquired acquire VBN cord-011793-hlktpla4 41 21 infections infection NNS cord-011793-hlktpla4 41 22 and and CC cord-011793-hlktpla4 41 23 reduce reduce VB cord-011793-hlktpla4 41 24 length length NN cord-011793-hlktpla4 41 25 of of IN cord-011793-hlktpla4 41 26 stay stay NN cord-011793-hlktpla4 41 27 . . . cord-011793-hlktpla4 42 1 Many many JJ cord-011793-hlktpla4 42 2 have have VBP cord-011793-hlktpla4 42 3 recommended recommend VBN cord-011793-hlktpla4 42 4 avoiding avoid VBG cord-011793-hlktpla4 42 5 noninvasive noninvasive JJ cord-011793-hlktpla4 42 6 ventilation ventilation NN cord-011793-hlktpla4 42 7 or or CC cord-011793-hlktpla4 42 8 high high JJ cord-011793-hlktpla4 42 9 - - HYPH cord-011793-hlktpla4 42 10 flow flow NN cord-011793-hlktpla4 42 11 nasal nasal NN cord-011793-hlktpla4 42 12 cannula cannula NN cord-011793-hlktpla4 42 13 because because IN cord-011793-hlktpla4 42 14 of of IN cord-011793-hlktpla4 42 15 risk risk NN cord-011793-hlktpla4 42 16 of of IN cord-011793-hlktpla4 42 17 increasing increase VBG cord-011793-hlktpla4 42 18 aerosolization aerosolization NN cord-011793-hlktpla4 42 19 ( ( -LRB- cord-011793-hlktpla4 42 20 18 18 CD cord-011793-hlktpla4 42 21 ) ) -RRB- cord-011793-hlktpla4 42 22 . . . cord-011793-hlktpla4 43 1 However however RB cord-011793-hlktpla4 43 2 , , , cord-011793-hlktpla4 43 3 these these DT cord-011793-hlktpla4 43 4 recommendations recommendation NNS cord-011793-hlktpla4 43 5 fail fail VBP cord-011793-hlktpla4 43 6 to to TO cord-011793-hlktpla4 43 7 reference reference VB cord-011793-hlktpla4 43 8 any any DT cord-011793-hlktpla4 43 9 studies study NNS cord-011793-hlktpla4 43 10 or or CC cord-011793-hlktpla4 43 11 supporting support VBG cord-011793-hlktpla4 43 12 data datum NNS cord-011793-hlktpla4 43 13 demonstrating demonstrate VBG cord-011793-hlktpla4 43 14 this this DT cord-011793-hlktpla4 43 15 to to TO cord-011793-hlktpla4 43 16 be be VB cord-011793-hlktpla4 43 17 the the DT cord-011793-hlktpla4 43 18 case case NN cord-011793-hlktpla4 43 19 in in IN cord-011793-hlktpla4 43 20 patients patient NNS cord-011793-hlktpla4 43 21 with with IN cord-011793-hlktpla4 43 22 COVID-19 COVID-19 NNP cord-011793-hlktpla4 43 23 and and CC cord-011793-hlktpla4 43 24 are be VBP cord-011793-hlktpla4 43 25 contrary contrary JJ cord-011793-hlktpla4 43 26 to to IN cord-011793-hlktpla4 43 27 both both PDT cord-011793-hlktpla4 43 28 the the DT cord-011793-hlktpla4 43 29 Surviving Surviving NNP cord-011793-hlktpla4 43 30 Sepsis Sepsis NNP cord-011793-hlktpla4 43 31 Campaign Campaign NNP cord-011793-hlktpla4 43 32 ( ( -LRB- cord-011793-hlktpla4 43 33 19 19 CD cord-011793-hlktpla4 43 34 ) ) -RRB- cord-011793-hlktpla4 43 35 and and CC cord-011793-hlktpla4 43 36 Australian australian JJ cord-011793-hlktpla4 43 37 and and CC cord-011793-hlktpla4 43 38 New New NNP cord-011793-hlktpla4 43 39 Zealand Zealand NNP cord-011793-hlktpla4 43 40 Intensive Intensive NNP cord-011793-hlktpla4 43 41 Care Care NNP cord-011793-hlktpla4 43 42 Society Society NNP cord-011793-hlktpla4 43 43 Guidelines Guidelines NNPS cord-011793-hlktpla4 43 44 ( ( -LRB- cord-011793-hlktpla4 43 45 20 20 CD cord-011793-hlktpla4 43 46 ) ) -RRB- cord-011793-hlktpla4 43 47 for for IN cord-011793-hlktpla4 43 48 treating treat VBG cord-011793-hlktpla4 43 49 COVID-19 covid-19 CD cord-011793-hlktpla4 43 50 , , , cord-011793-hlktpla4 43 51 both both DT cord-011793-hlktpla4 43 52 of of IN cord-011793-hlktpla4 43 53 which which WDT cord-011793-hlktpla4 43 54 recommend recommend VBP cord-011793-hlktpla4 43 55 using use VBG cord-011793-hlktpla4 43 56 these these DT cord-011793-hlktpla4 43 57 devices device NNS cord-011793-hlktpla4 43 58 . . . cord-011793-hlktpla4 44 1 Changing change VBG cord-011793-hlktpla4 44 2 practice practice NN cord-011793-hlktpla4 44 3 to to TO cord-011793-hlktpla4 44 4 avoid avoid VB cord-011793-hlktpla4 44 5 these these DT cord-011793-hlktpla4 44 6 oxygen oxygen NN cord-011793-hlktpla4 44 7 - - HYPH cord-011793-hlktpla4 44 8 delivery delivery NN cord-011793-hlktpla4 44 9 devices device NNS cord-011793-hlktpla4 44 10 has have VBZ cord-011793-hlktpla4 44 11 dramatically dramatically RB cord-011793-hlktpla4 44 12 altered alter VBN cord-011793-hlktpla4 44 13 the the DT cord-011793-hlktpla4 44 14 care care NN cord-011793-hlktpla4 44 15 of of IN cord-011793-hlktpla4 44 16 patients patient NNS cord-011793-hlktpla4 44 17 with with IN cord-011793-hlktpla4 44 18 COVID-19 COVID-19 NNP cord-011793-hlktpla4 44 19 , , , cord-011793-hlktpla4 44 20 potentially potentially RB cord-011793-hlktpla4 44 21 to to IN cord-011793-hlktpla4 44 22 their -PRON- PRP$ cord-011793-hlktpla4 44 23 detriment detriment NN cord-011793-hlktpla4 44 24 ( ( -LRB- cord-011793-hlktpla4 44 25 21 21 CD cord-011793-hlktpla4 44 26 ) ) -RRB- cord-011793-hlktpla4 44 27 . . . cord-011793-hlktpla4 45 1 In in IN cord-011793-hlktpla4 45 2 a a DT cord-011793-hlktpla4 45 3 pandemic pandemic NN cord-011793-hlktpla4 45 4 that that WDT cord-011793-hlktpla4 45 5 is be VBZ cord-011793-hlktpla4 45 6 projected project VBN cord-011793-hlktpla4 45 7 to to TO cord-011793-hlktpla4 45 8 sicken sicken VB cord-011793-hlktpla4 45 9 millions million NNS cord-011793-hlktpla4 45 10 and and CC cord-011793-hlktpla4 45 11 cause cause VB cord-011793-hlktpla4 45 12 acute acute JJ cord-011793-hlktpla4 45 13 respiratory respiratory JJ cord-011793-hlktpla4 45 14 failure failure NN cord-011793-hlktpla4 45 15 and and CC cord-011793-hlktpla4 45 16 critical critical JJ cord-011793-hlktpla4 45 17 illness illness NN cord-011793-hlktpla4 45 18 in in IN cord-011793-hlktpla4 45 19 tens ten NNS cord-011793-hlktpla4 45 20 or or CC cord-011793-hlktpla4 45 21 hundreds hundred NNS cord-011793-hlktpla4 45 22 of of IN cord-011793-hlktpla4 45 23 thousands thousand NNS cord-011793-hlktpla4 45 24 , , , cord-011793-hlktpla4 45 25 removing remove VBG cord-011793-hlktpla4 45 26 evidence evidence NN cord-011793-hlktpla4 45 27 - - HYPH cord-011793-hlktpla4 45 28 based base VBN cord-011793-hlktpla4 45 29 respiratory respiratory JJ cord-011793-hlktpla4 45 30 support support NN cord-011793-hlktpla4 45 31 devices device NNS cord-011793-hlktpla4 45 32 entirely entirely RB cord-011793-hlktpla4 45 33 from from IN cord-011793-hlktpla4 45 34 our -PRON- PRP$ cord-011793-hlktpla4 45 35 arsenal arsenal NN cord-011793-hlktpla4 45 36 of of IN cord-011793-hlktpla4 45 37 weapons weapon NNS cord-011793-hlktpla4 45 38 to to TO cord-011793-hlktpla4 45 39 fight fight VB cord-011793-hlktpla4 45 40 COVID-19 COVID-19 NNP cord-011793-hlktpla4 45 41 and and CC cord-011793-hlktpla4 45 42 intubating intubate VBG cord-011793-hlktpla4 45 43 everyone everyone NN cord-011793-hlktpla4 45 44 " " `` cord-011793-hlktpla4 45 45 early early JJ cord-011793-hlktpla4 45 46 " " '' cord-011793-hlktpla4 45 47 will will MD cord-011793-hlktpla4 45 48 certainly certainly RB cord-011793-hlktpla4 45 49 result result VB cord-011793-hlktpla4 45 50 in in IN cord-011793-hlktpla4 45 51 a a DT cord-011793-hlktpla4 45 52 losing lose VBG cord-011793-hlktpla4 45 53 battle battle NN cord-011793-hlktpla4 45 54 . . . cord-011793-hlktpla4 46 1 ICU ICU NNP cord-011793-hlktpla4 46 2 capacity capacity NN cord-011793-hlktpla4 46 3 , , , cord-011793-hlktpla4 46 4 ventilator ventilator NN cord-011793-hlktpla4 46 5 supplies supply NNS cord-011793-hlktpla4 46 6 , , , cord-011793-hlktpla4 46 7 and and CC cord-011793-hlktpla4 46 8 survival survival NN cord-011793-hlktpla4 46 9 during during IN cord-011793-hlktpla4 46 10 the the DT cord-011793-hlktpla4 46 11 COVID-19 COVID-19 NNP cord-011793-hlktpla4 46 12 pandemic pandemic NN cord-011793-hlktpla4 46 13 could could MD cord-011793-hlktpla4 46 14 all all RB cord-011793-hlktpla4 46 15 be be VB cord-011793-hlktpla4 46 16 increased increase VBN cord-011793-hlktpla4 46 17 today today NN cord-011793-hlktpla4 46 18 if if IN cord-011793-hlktpla4 46 19 the the DT cord-011793-hlktpla4 46 20 critical critical JJ cord-011793-hlktpla4 46 21 care care NN cord-011793-hlktpla4 46 22 community community NN cord-011793-hlktpla4 46 23 practiced practice VBD cord-011793-hlktpla4 46 24 the the DT cord-011793-hlktpla4 46 25 evidenced evidence VBN cord-011793-hlktpla4 46 26 - - HYPH cord-011793-hlktpla4 46 27 based base VBN cord-011793-hlktpla4 46 28 principles principle NNS cord-011793-hlktpla4 46 29 discovered discover VBN cord-011793-hlktpla4 46 30 over over IN cord-011793-hlktpla4 46 31 the the DT cord-011793-hlktpla4 46 32 last last JJ cord-011793-hlktpla4 46 33 3 3 CD cord-011793-hlktpla4 46 34 decades decade NNS cord-011793-hlktpla4 46 35 . . . cord-011793-hlktpla4 47 1 Innumerable innumerable JJ cord-011793-hlktpla4 47 2 randomized randomized JJ cord-011793-hlktpla4 47 3 controlled control VBN cord-011793-hlktpla4 47 4 trials trial NNS cord-011793-hlktpla4 47 5 have have VBP cord-011793-hlktpla4 47 6 produced produce VBN cord-011793-hlktpla4 47 7 the the DT cord-011793-hlktpla4 47 8 robust robust JJ cord-011793-hlktpla4 47 9 knowledge knowledge NN cord-011793-hlktpla4 47 10 necessary necessary JJ cord-011793-hlktpla4 47 11 to to TO cord-011793-hlktpla4 47 12 care care VB cord-011793-hlktpla4 47 13 for for IN cord-011793-hlktpla4 47 14 patients patient NNS cord-011793-hlktpla4 47 15 with with IN cord-011793-hlktpla4 47 16 COVID-19 covid-19 DT cord-011793-hlktpla4 47 17 while while IN cord-011793-hlktpla4 47 18 we -PRON- PRP cord-011793-hlktpla4 47 19 await await VBP cord-011793-hlktpla4 47 20 high high JJ cord-011793-hlktpla4 47 21 - - HYPH cord-011793-hlktpla4 47 22 quality quality NN cord-011793-hlktpla4 47 23 evidence evidence NN cord-011793-hlktpla4 47 24 of of IN cord-011793-hlktpla4 47 25 whether whether IN cord-011793-hlktpla4 47 26 any any DT cord-011793-hlktpla4 47 27 new new JJ cord-011793-hlktpla4 47 28 therapies therapy NNS cord-011793-hlktpla4 47 29 improve improve VBP cord-011793-hlktpla4 47 30 outcomes outcome NNS cord-011793-hlktpla4 47 31 . . . cord-011793-hlktpla4 48 1 Improving improve VBG cord-011793-hlktpla4 48 2 capacity capacity NN cord-011793-hlktpla4 48 3 and and CC cord-011793-hlktpla4 48 4 survival survival NN cord-011793-hlktpla4 48 5 will will MD cord-011793-hlktpla4 48 6 be be VB cord-011793-hlktpla4 48 7 accomplished accomplish VBN cord-011793-hlktpla4 48 8 by by IN cord-011793-hlktpla4 48 9 using use VBG cord-011793-hlktpla4 48 10 noninvasive noninvasive JJ cord-011793-hlktpla4 48 11 ventilation ventilation NN cord-011793-hlktpla4 48 12 or or CC cord-011793-hlktpla4 48 13 high high JJ cord-011793-hlktpla4 48 14 - - HYPH cord-011793-hlktpla4 48 15 flow flow NN cord-011793-hlktpla4 48 16 nasal nasal NN cord-011793-hlktpla4 48 17 cannulas cannula NNS cord-011793-hlktpla4 48 18 to to TO cord-011793-hlktpla4 48 19 prevent prevent VB cord-011793-hlktpla4 48 20 intubation intubation NN cord-011793-hlktpla4 48 21 or or CC cord-011793-hlktpla4 48 22 reintubation reintubation NN cord-011793-hlktpla4 48 23 . . . cord-011793-hlktpla4 49 1 In in IN cord-011793-hlktpla4 49 2 the the DT cord-011793-hlktpla4 49 3 intubated intubate VBN cord-011793-hlktpla4 49 4 patient patient NN cord-011793-hlktpla4 49 5 , , , cord-011793-hlktpla4 49 6 the the DT cord-011793-hlktpla4 49 7 use use NN cord-011793-hlktpla4 49 8 of of IN cord-011793-hlktpla4 49 9 lung lung NN cord-011793-hlktpla4 49 10 - - HYPH cord-011793-hlktpla4 49 11 protective protective JJ cord-011793-hlktpla4 49 12 ventilation ventilation NN cord-011793-hlktpla4 49 13 , , , cord-011793-hlktpla4 49 14 PEEP peep NN cord-011793-hlktpla4 49 15 , , , cord-011793-hlktpla4 49 16 prone prone JJ cord-011793-hlktpla4 49 17 positioning positioning NN cord-011793-hlktpla4 49 18 if if IN cord-011793-hlktpla4 49 19 needed need VBN cord-011793-hlktpla4 49 20 , , , cord-011793-hlktpla4 49 21 a a DT cord-011793-hlktpla4 49 22 conservative conservative JJ cord-011793-hlktpla4 49 23 fluid fluid JJ cord-011793-hlktpla4 49 24 - - HYPH cord-011793-hlktpla4 49 25 management management NN cord-011793-hlktpla4 49 26 strategy strategy NN cord-011793-hlktpla4 49 27 , , , cord-011793-hlktpla4 49 28 and and CC cord-011793-hlktpla4 49 29 paired pair VBN cord-011793-hlktpla4 49 30 awakening awakening NN cord-011793-hlktpla4 49 31 and and CC cord-011793-hlktpla4 49 32 spontaneous spontaneous JJ cord-011793-hlktpla4 49 33 breathing breathing NN cord-011793-hlktpla4 49 34 trials trial NNS cord-011793-hlktpla4 49 35 have have VBP cord-011793-hlktpla4 49 36 all all DT cord-011793-hlktpla4 49 37 been be VBN cord-011793-hlktpla4 49 38 shown show VBN cord-011793-hlktpla4 49 39 to to TO cord-011793-hlktpla4 49 40 improve improve VB cord-011793-hlktpla4 49 41 outcomes outcome NNS cord-011793-hlktpla4 49 42 . . . cord-011793-hlktpla4 50 1 In in IN cord-011793-hlktpla4 50 2 this this DT cord-011793-hlktpla4 50 3 time time NN cord-011793-hlktpla4 50 4 of of IN cord-011793-hlktpla4 50 5 increased increase VBN cord-011793-hlktpla4 50 6 work work NN cord-011793-hlktpla4 50 7 and and CC cord-011793-hlktpla4 50 8 uncertainty uncertainty NN cord-011793-hlktpla4 50 9 , , , cord-011793-hlktpla4 50 10 many many JJ cord-011793-hlktpla4 50 11 have have VBP cord-011793-hlktpla4 50 12 forgotten forget VBN cord-011793-hlktpla4 50 13 everything everything NN cord-011793-hlktpla4 50 14 that that WDT cord-011793-hlktpla4 50 15 we -PRON- PRP cord-011793-hlktpla4 50 16 do do VBP cord-011793-hlktpla4 50 17 for for IN cord-011793-hlktpla4 50 18 our -PRON- PRP$ cord-011793-hlktpla4 50 19 critically critically RB cord-011793-hlktpla4 50 20 ill ill JJ cord-011793-hlktpla4 50 21 patients patient NNS cord-011793-hlktpla4 50 22 . . . cord-011793-hlktpla4 51 1 Hopefully hopefully RB cord-011793-hlktpla4 51 2 , , , cord-011793-hlktpla4 51 3 this this DT cord-011793-hlktpla4 51 4 is be VBZ cord-011793-hlktpla4 51 5 because because IN cord-011793-hlktpla4 51 6 we -PRON- PRP cord-011793-hlktpla4 51 7 do do VBP cord-011793-hlktpla4 51 8 it -PRON- PRP cord-011793-hlktpla4 51 9 so so RB cord-011793-hlktpla4 51 10 often often RB cord-011793-hlktpla4 51 11 that that IN cord-011793-hlktpla4 51 12 it -PRON- PRP cord-011793-hlktpla4 51 13 becomes become VBZ cord-011793-hlktpla4 51 14 second second JJ cord-011793-hlktpla4 51 15 nature nature NN cord-011793-hlktpla4 51 16 and and CC cord-011793-hlktpla4 51 17 therefore therefore RB cord-011793-hlktpla4 51 18 is be VBZ cord-011793-hlktpla4 51 19 not not RB cord-011793-hlktpla4 51 20 thought think VBN cord-011793-hlktpla4 51 21 of of IN cord-011793-hlktpla4 51 22 as as IN cord-011793-hlktpla4 51 23 special special JJ cord-011793-hlktpla4 51 24 treatment treatment NN cord-011793-hlktpla4 51 25 . . . cord-011793-hlktpla4 52 1 However however RB cord-011793-hlktpla4 52 2 , , , cord-011793-hlktpla4 52 3 potentially potentially RB cord-011793-hlktpla4 52 4 worse bad JJR cord-011793-hlktpla4 52 5 , , , cord-011793-hlktpla4 52 6 practitioners practitioner NNS cord-011793-hlktpla4 52 7 may may MD cord-011793-hlktpla4 52 8 not not RB cord-011793-hlktpla4 52 9 have have VB cord-011793-hlktpla4 52 10 forgotten forget VBN cord-011793-hlktpla4 52 11 but but CC cord-011793-hlktpla4 52 12 may may MD cord-011793-hlktpla4 52 13 be be VB cord-011793-hlktpla4 52 14 purposefully purposefully RB cord-011793-hlktpla4 52 15 treating treat VBG cord-011793-hlktpla4 52 16 patients patient NNS cord-011793-hlktpla4 52 17 differently differently RB cord-011793-hlktpla4 52 18 in in IN cord-011793-hlktpla4 52 19 their -PRON- PRP$ cord-011793-hlktpla4 52 20 desire desire NN cord-011793-hlktpla4 52 21 to to TO cord-011793-hlktpla4 52 22 feel feel VB cord-011793-hlktpla4 52 23 like like IN cord-011793-hlktpla4 52 24 they -PRON- PRP cord-011793-hlktpla4 52 25 " " `` cord-011793-hlktpla4 52 26 are be VBP cord-011793-hlktpla4 52 27 doing do VBG cord-011793-hlktpla4 52 28 something something NN cord-011793-hlktpla4 52 29 . . . cord-011793-hlktpla4 52 30 " " '' cord-011793-hlktpla4 53 1 Not not RB cord-011793-hlktpla4 53 2 giving give VBG cord-011793-hlktpla4 53 3 a a DT cord-011793-hlktpla4 53 4 medication medication NN cord-011793-hlktpla4 53 5 lacking lack VBG cord-011793-hlktpla4 53 6 high high JJ cord-011793-hlktpla4 53 7 - - HYPH cord-011793-hlktpla4 53 8 quality quality NN cord-011793-hlktpla4 53 9 evidence evidence NN cord-011793-hlktpla4 53 10 of of IN cord-011793-hlktpla4 53 11 benefit benefit NN cord-011793-hlktpla4 53 12 does do VBZ cord-011793-hlktpla4 53 13 not not RB cord-011793-hlktpla4 53 14 equal equal VB cord-011793-hlktpla4 53 15 just just RB cord-011793-hlktpla4 53 16 standing stand VBG cord-011793-hlktpla4 53 17 there there RB cord-011793-hlktpla4 53 18 and and CC cord-011793-hlktpla4 53 19 doing do VBG cord-011793-hlktpla4 53 20 nothing nothing NN cord-011793-hlktpla4 53 21 . . . cord-011793-hlktpla4 54 1 To to IN cord-011793-hlktpla4 54 2 the the DT cord-011793-hlktpla4 54 3 contrary contrary NN cord-011793-hlktpla4 54 4 , , , cord-011793-hlktpla4 54 5 providing provide VBG cord-011793-hlktpla4 54 6 evidence evidence NN cord-011793-hlktpla4 54 7 - - HYPH cord-011793-hlktpla4 54 8 based base VBN cord-011793-hlktpla4 54 9 critical critical JJ cord-011793-hlktpla4 54 10 care care NN cord-011793-hlktpla4 54 11 is be VBZ cord-011793-hlktpla4 54 12 more more JJR cord-011793-hlktpla4 54 13 than than IN cord-011793-hlktpla4 54 14 just just RB cord-011793-hlktpla4 54 15 doing do VBG cord-011793-hlktpla4 54 16 something something NN cord-011793-hlktpla4 54 17 for for IN cord-011793-hlktpla4 54 18 our -PRON- PRP$ cord-011793-hlktpla4 54 19 patients patient NNS cord-011793-hlktpla4 54 20 . . . cord-011793-hlktpla4 55 1 It -PRON- PRP cord-011793-hlktpla4 55 2 is be VBZ cord-011793-hlktpla4 55 3 providing provide VBG cord-011793-hlktpla4 55 4 them -PRON- PRP cord-011793-hlktpla4 55 5 with with IN cord-011793-hlktpla4 55 6 the the DT cord-011793-hlktpla4 55 7 best good JJS cord-011793-hlktpla4 55 8 possible possible JJ cord-011793-hlktpla4 55 9 chance chance NN cord-011793-hlktpla4 55 10 of of IN cord-011793-hlktpla4 55 11 surviving survive VBG cord-011793-hlktpla4 55 12 without without IN cord-011793-hlktpla4 55 13 complications complication NNS cord-011793-hlktpla4 55 14 and and CC cord-011793-hlktpla4 55 15 not not RB cord-011793-hlktpla4 55 16 putting put VBG cord-011793-hlktpla4 55 17 them -PRON- PRP cord-011793-hlktpla4 55 18 at at IN cord-011793-hlktpla4 55 19 risk risk NN cord-011793-hlktpla4 55 20 for for IN cord-011793-hlktpla4 55 21 poor poor JJ cord-011793-hlktpla4 55 22 outcomes outcome NNS cord-011793-hlktpla4 55 23 from from IN cord-011793-hlktpla4 55 24 non non JJ cord-011793-hlktpla4 55 25 - - JJ cord-011793-hlktpla4 55 26 evidencebased evidencebased JJ cord-011793-hlktpla4 55 27 care care NN cord-011793-hlktpla4 55 28 . . . cord-011793-hlktpla4 55 29 " " '' cord-011793-hlktpla4 56 1 Fortune fortune NN cord-011793-hlktpla4 56 2 favors favor VBZ cord-011793-hlktpla4 56 3 the the DT cord-011793-hlktpla4 56 4 bold bold JJ cord-011793-hlktpla4 56 5 , , , cord-011793-hlktpla4 56 6 " " '' cord-011793-hlktpla4 56 7 and and CC cord-011793-hlktpla4 56 8 we -PRON- PRP cord-011793-hlktpla4 56 9 should should MD cord-011793-hlktpla4 56 10 boldly boldly RB cord-011793-hlktpla4 56 11 institute institute VB cord-011793-hlktpla4 56 12 the the DT cord-011793-hlktpla4 56 13 evidencebased evidencebased JJ cord-011793-hlktpla4 56 14 medicine medicine NN cord-011793-hlktpla4 56 15 we -PRON- PRP cord-011793-hlktpla4 56 16 have have VBP cord-011793-hlktpla4 56 17 been be VBN cord-011793-hlktpla4 56 18 taught teach VBN cord-011793-hlktpla4 56 19 by by IN cord-011793-hlktpla4 56 20 the the DT cord-011793-hlktpla4 56 21 physician physician NN cord-011793-hlktpla4 56 22 , , , cord-011793-hlktpla4 56 23 nursing nursing NN cord-011793-hlktpla4 56 24 , , , cord-011793-hlktpla4 56 25 and and CC cord-011793-hlktpla4 56 26 respiratory respiratory JJ cord-011793-hlktpla4 56 27 therapy therapy NN cord-011793-hlktpla4 56 28 giants giant NNS cord-011793-hlktpla4 56 29 that that WDT cord-011793-hlktpla4 56 30 have have VBP cord-011793-hlktpla4 56 31 come come VBN cord-011793-hlktpla4 56 32 before before IN cord-011793-hlktpla4 56 33 us -PRON- PRP cord-011793-hlktpla4 56 34 . . . cord-011793-hlktpla4 57 1 It -PRON- PRP cord-011793-hlktpla4 57 2 is be VBZ cord-011793-hlktpla4 57 3 our -PRON- PRP$ cord-011793-hlktpla4 57 4 obligation obligation NN cord-011793-hlktpla4 57 5 , , , cord-011793-hlktpla4 57 6 what what WP cord-011793-hlktpla4 57 7 our -PRON- PRP$ cord-011793-hlktpla4 57 8 patients patient NNS cord-011793-hlktpla4 57 9 expect expect VBP cord-011793-hlktpla4 57 10 from from IN cord-011793-hlktpla4 57 11 us -PRON- PRP cord-011793-hlktpla4 57 12 , , , cord-011793-hlktpla4 57 13 and and CC cord-011793-hlktpla4 57 14 exactly exactly RB cord-011793-hlktpla4 57 15 what what WP cord-011793-hlktpla4 57 16 we -PRON- PRP cord-011793-hlktpla4 57 17 owe owe VBP cord-011793-hlktpla4 57 18 them -PRON- PRP cord-011793-hlktpla4 57 19 . . . cord-011793-hlktpla4 58 1 n n NNP cord-011793-hlktpla4 59 1 Effective effective JJ cord-011793-hlktpla4 59 2 treatment treatment NN cord-011793-hlktpla4 59 3 of of IN cord-011793-hlktpla4 59 4 severe severe JJ cord-011793-hlktpla4 59 5 COVID-19 covid-19 JJ cord-011793-hlktpla4 59 6 patients patient NNS cord-011793-hlktpla4 59 7 with with IN cord-011793-hlktpla4 59 8 tocilizumab tocilizumab NNP cord-011793-hlktpla4 59 9 Tissue Tissue NNP cord-011793-hlktpla4 59 10 plasminogen plasminogen NN cord-011793-hlktpla4 59 11 activator activator NN cord-011793-hlktpla4 59 12 ( ( -LRB- cord-011793-hlktpla4 59 13 tPA tPA NNP cord-011793-hlktpla4 59 14 ) ) -RRB- cord-011793-hlktpla4 59 15 treatment treatment NN cord-011793-hlktpla4 59 16 for for IN cord-011793-hlktpla4 59 17 COVID-19 covid-19 JJ cord-011793-hlktpla4 59 18 associated associated JJ cord-011793-hlktpla4 59 19 acute acute JJ cord-011793-hlktpla4 59 20 respiratory respiratory JJ cord-011793-hlktpla4 59 21 distress distress NN cord-011793-hlktpla4 59 22 syndrome syndrome NN cord-011793-hlktpla4 59 23 ( ( -LRB- cord-011793-hlktpla4 59 24 ARDS ARDS NNP cord-011793-hlktpla4 59 25 ) ) -RRB- cord-011793-hlktpla4 59 26 : : : cord-011793-hlktpla4 59 27 a a DT cord-011793-hlktpla4 59 28 case case NN cord-011793-hlktpla4 59 29 series series NN cord-011793-hlktpla4 59 30 Evaluating evaluate VBG cord-011793-hlktpla4 59 31 the the DT cord-011793-hlktpla4 59 32 efficacy efficacy NN cord-011793-hlktpla4 59 33 and and CC cord-011793-hlktpla4 59 34 safety safety NN cord-011793-hlktpla4 59 35 of of IN cord-011793-hlktpla4 59 36 two two CD cord-011793-hlktpla4 59 37 doses dose NNS cord-011793-hlktpla4 59 38 of of IN cord-011793-hlktpla4 59 39 the the DT cord-011793-hlktpla4 59 40 polyclonal polyclonal JJ cord-011793-hlktpla4 59 41 anti anti JJ cord-011793-hlktpla4 59 42 - - JJ cord-011793-hlktpla4 59 43 tumor tumor JJ cord-011793-hlktpla4 59 44 necrosis necrosis NN cord-011793-hlktpla4 59 45 factor factor NN cord-011793-hlktpla4 59 46 - - : cord-011793-hlktpla4 59 47 a a DT cord-011793-hlktpla4 59 48 fragment fragment NN cord-011793-hlktpla4 59 49 antibody antibody NN cord-011793-hlktpla4 60 1 AZD9773 AZD9773 NNP cord-011793-hlktpla4 60 2 in in IN cord-011793-hlktpla4 60 3 adult adult NN cord-011793-hlktpla4 60 4 patients patient NNS cord-011793-hlktpla4 60 5 with with IN cord-011793-hlktpla4 60 6 severe severe JJ cord-011793-hlktpla4 60 7 sepsis sepsis NN cord-011793-hlktpla4 61 1 and/or and/or CC cord-011793-hlktpla4 61 2 septic septic JJ cord-011793-hlktpla4 61 3 shock shock NN cord-011793-hlktpla4 61 4 : : : cord-011793-hlktpla4 62 1 randomized randomized JJ cord-011793-hlktpla4 62 2 , , , cord-011793-hlktpla4 62 3 double double JJ cord-011793-hlktpla4 62 4 - - HYPH cord-011793-hlktpla4 62 5 blind blind JJ cord-011793-hlktpla4 62 6 , , , cord-011793-hlktpla4 62 7 placebo placebo NN cord-011793-hlktpla4 62 8 - - HYPH cord-011793-hlktpla4 62 9 controlled control VBN cord-011793-hlktpla4 62 10 phase phase NN cord-011793-hlktpla4 62 11 IIb iib NN cord-011793-hlktpla4 62 12 study study NN cord-011793-hlktpla4 62 13 Effect effect NN cord-011793-hlktpla4 62 14 of of IN cord-011793-hlktpla4 62 15 intravenous intravenous JJ cord-011793-hlktpla4 62 16 interferon interferon NN cord-011793-hlktpla4 62 17 b-1a b-1a NN cord-011793-hlktpla4 62 18 on on IN cord-011793-hlktpla4 62 19 death death NN cord-011793-hlktpla4 62 20 and and CC cord-011793-hlktpla4 62 21 days day NNS cord-011793-hlktpla4 62 22 free free JJ cord-011793-hlktpla4 62 23 from from IN cord-011793-hlktpla4 62 24 mechanical mechanical JJ cord-011793-hlktpla4 62 25 ventilation ventilation NN cord-011793-hlktpla4 62 26 among among IN cord-011793-hlktpla4 62 27 patients patient NNS cord-011793-hlktpla4 62 28 with with IN cord-011793-hlktpla4 62 29 moderate moderate JJ cord-011793-hlktpla4 62 30 to to IN cord-011793-hlktpla4 62 31 severe severe JJ cord-011793-hlktpla4 62 32 acute acute JJ cord-011793-hlktpla4 62 33 respiratory respiratory JJ cord-011793-hlktpla4 62 34 distress distress NN cord-011793-hlktpla4 62 35 syndrome syndrome NN cord-011793-hlktpla4 62 36 : : : cord-011793-hlktpla4 62 37 a a DT cord-011793-hlktpla4 62 38 randomized randomized JJ cord-011793-hlktpla4 62 39 clinical clinical JJ cord-011793-hlktpla4 62 40 trial trial NN cord-011793-hlktpla4 62 41 Randomized randomized JJ cord-011793-hlktpla4 62 42 clinical clinical JJ cord-011793-hlktpla4 62 43 trial trial NN cord-011793-hlktpla4 62 44 of of IN cord-011793-hlktpla4 62 45 activated activate VBN cord-011793-hlktpla4 62 46 protein protein NN cord-011793-hlktpla4 62 47 C C NNP cord-011793-hlktpla4 62 48 for for IN cord-011793-hlktpla4 62 49 the the DT cord-011793-hlktpla4 62 50 treatment treatment NN cord-011793-hlktpla4 62 51 of of IN cord-011793-hlktpla4 62 52 acute acute JJ cord-011793-hlktpla4 62 53 lung lung NN cord-011793-hlktpla4 62 54 injury injury NN cord-011793-hlktpla4 62 55 National National NNP cord-011793-hlktpla4 62 56 Heart Heart NNP cord-011793-hlktpla4 62 57 , , , cord-011793-hlktpla4 62 58 Lung Lung NNP cord-011793-hlktpla4 62 59 , , , cord-011793-hlktpla4 62 60 and and CC cord-011793-hlktpla4 62 61 Blood Blood NNP cord-011793-hlktpla4 62 62 Institute Institute NNP cord-011793-hlktpla4 62 63 ARDS ARDS NNP cord-011793-hlktpla4 62 64 Clinical Clinical NNP cord-011793-hlktpla4 62 65 Trials Trials NNPS cord-011793-hlktpla4 62 66 Network Network NNP cord-011793-hlktpla4 62 67 . . . cord-011793-hlktpla4 63 1 Rosuvastatin Rosuvastatin NNP cord-011793-hlktpla4 63 2 for for IN cord-011793-hlktpla4 63 3 sepsis sepsis NN cord-011793-hlktpla4 63 4 - - HYPH cord-011793-hlktpla4 63 5 associated associate VBN cord-011793-hlktpla4 63 6 acute acute JJ cord-011793-hlktpla4 63 7 respiratory respiratory JJ cord-011793-hlktpla4 63 8 distress distress NN cord-011793-hlktpla4 63 9 syndrome syndrome NN cord-011793-hlktpla4 63 10 Infectious Infectious NNP cord-011793-hlktpla4 63 11 Disease Disease NNP cord-011793-hlktpla4 63 12 Society Society NNP cord-011793-hlktpla4 63 13 of of IN cord-011793-hlktpla4 63 14 America America NNP cord-011793-hlktpla4 63 15 guidelines guideline NNS cord-011793-hlktpla4 63 16 on on IN cord-011793-hlktpla4 63 17 the the DT cord-011793-hlktpla4 63 18 treatment treatment NN cord-011793-hlktpla4 63 19 and and CC cord-011793-hlktpla4 63 20 management management NN cord-011793-hlktpla4 63 21 of of IN cord-011793-hlktpla4 63 22 patients patient NNS cord-011793-hlktpla4 63 23 with with IN cord-011793-hlktpla4 63 24 COVID-19 covid-19 JJ cord-011793-hlktpla4 63 25 infection infection NN cord-011793-hlktpla4 63 26 Outcomes outcome NNS cord-011793-hlktpla4 63 27 and and CC cord-011793-hlktpla4 63 28 statistical statistical JJ cord-011793-hlktpla4 63 29 power power NN cord-011793-hlktpla4 63 30 in in IN cord-011793-hlktpla4 63 31 adult adult NN cord-011793-hlktpla4 63 32 critical critical JJ cord-011793-hlktpla4 63 33 care care NN cord-011793-hlktpla4 63 34 randomized randomized JJ cord-011793-hlktpla4 63 35 trials trial NNS cord-011793-hlktpla4 64 1 COVID-19 COVID-19 NNP cord-011793-hlktpla4 64 2 does do VBZ cord-011793-hlktpla4 64 3 not not RB cord-011793-hlktpla4 64 4 lead lead VB cord-011793-hlktpla4 64 5 to to IN cord-011793-hlktpla4 64 6 a a DT cord-011793-hlktpla4 64 7 " " `` cord-011793-hlktpla4 64 8 typical typical JJ cord-011793-hlktpla4 64 9 " " '' cord-011793-hlktpla4 64 10 acute acute JJ cord-011793-hlktpla4 64 11 respiratory respiratory JJ cord-011793-hlktpla4 64 12 distress distress NN cord-011793-hlktpla4 64 13 syndrome syndrome NN cord-011793-hlktpla4 64 14 Acute Acute NNP cord-011793-hlktpla4 64 15 Respiratory Respiratory NNP cord-011793-hlktpla4 64 16 Distress Distress NNP cord-011793-hlktpla4 64 17 Syndrome Syndrome NNP cord-011793-hlktpla4 64 18 Network Network NNP cord-011793-hlktpla4 64 19 . . . cord-011793-hlktpla4 65 1 Ventilation ventilation NN cord-011793-hlktpla4 65 2 with with IN cord-011793-hlktpla4 65 3 lower low JJR cord-011793-hlktpla4 65 4 tidal tidal JJ cord-011793-hlktpla4 65 5 volumes volume NNS cord-011793-hlktpla4 65 6 as as IN cord-011793-hlktpla4 65 7 compared compare VBN cord-011793-hlktpla4 65 8 with with IN cord-011793-hlktpla4 65 9 traditional traditional JJ cord-011793-hlktpla4 65 10 tidal tidal JJ cord-011793-hlktpla4 65 11 volumes volume NNS cord-011793-hlktpla4 65 12 for for IN cord-011793-hlktpla4 65 13 acute acute JJ cord-011793-hlktpla4 65 14 lung lung NN cord-011793-hlktpla4 65 15 injury injury NN cord-011793-hlktpla4 65 16 and and CC cord-011793-hlktpla4 65 17 the the DT cord-011793-hlktpla4 65 18 acute acute JJ cord-011793-hlktpla4 65 19 respiratory respiratory JJ cord-011793-hlktpla4 65 20 distress distress NN cord-011793-hlktpla4 65 21 syndrome syndrome NN cord-011793-hlktpla4 65 22 Tidal tidal JJ cord-011793-hlktpla4 65 23 volume volume NN cord-011793-hlktpla4 65 24 reduction reduction NN cord-011793-hlktpla4 65 25 in in IN cord-011793-hlktpla4 65 26 patients patient NNS cord-011793-hlktpla4 65 27 with with IN cord-011793-hlktpla4 65 28 acute acute JJ cord-011793-hlktpla4 65 29 lung lung NN cord-011793-hlktpla4 65 30 injury injury NN cord-011793-hlktpla4 65 31 when when WRB cord-011793-hlktpla4 65 32 plateau plateau NN cord-011793-hlktpla4 65 33 pressures pressure NNS cord-011793-hlktpla4 65 34 are be VBP cord-011793-hlktpla4 65 35 not not RB cord-011793-hlktpla4 65 36 high high JJ cord-011793-hlktpla4 65 37 IMPROVE IMPROVE NNP cord-011793-hlktpla4 65 38 Study Study NNP cord-011793-hlktpla4 65 39 Group Group NNP cord-011793-hlktpla4 65 40 . . . cord-011793-hlktpla4 66 1 A a DT cord-011793-hlktpla4 66 2 trial trial NN cord-011793-hlktpla4 66 3 of of IN cord-011793-hlktpla4 66 4 intraoperative intraoperative JJ cord-011793-hlktpla4 66 5 low low RB cord-011793-hlktpla4 66 6 - - HYPH cord-011793-hlktpla4 66 7 tidal tidal JJ cord-011793-hlktpla4 66 8 - - HYPH cord-011793-hlktpla4 66 9 volume volume NN cord-011793-hlktpla4 66 10 ventilation ventilation NN cord-011793-hlktpla4 66 11 in in IN cord-011793-hlktpla4 66 12 abdominal abdominal JJ cord-011793-hlktpla4 66 13 surgery surgery NN cord-011793-hlktpla4 66 14 Higher higher RBR cord-011793-hlktpla4 66 15 vs vs IN cord-011793-hlktpla4 66 16 lower low JJR cord-011793-hlktpla4 66 17 positive positive JJ cord-011793-hlktpla4 66 18 end end NN cord-011793-hlktpla4 66 19 - - HYPH cord-011793-hlktpla4 66 20 expiratory expiratory NN cord-011793-hlktpla4 66 21 pressure pressure NN cord-011793-hlktpla4 66 22 in in IN cord-011793-hlktpla4 66 23 patients patient NNS cord-011793-hlktpla4 66 24 with with IN cord-011793-hlktpla4 66 25 acute acute JJ cord-011793-hlktpla4 66 26 lung lung NN cord-011793-hlktpla4 66 27 injury injury NN cord-011793-hlktpla4 66 28 and and CC cord-011793-hlktpla4 66 29 acute acute JJ cord-011793-hlktpla4 66 30 respiratory respiratory JJ cord-011793-hlktpla4 66 31 distress distress NN cord-011793-hlktpla4 66 32 syndrome syndrome NN cord-011793-hlktpla4 66 33 : : : cord-011793-hlktpla4 66 34 systematic systematic JJ cord-011793-hlktpla4 66 35 review review NN cord-011793-hlktpla4 66 36 and and CC cord-011793-hlktpla4 66 37 meta meta NNP cord-011793-hlktpla4 66 38 - - HYPH cord-011793-hlktpla4 66 39 analysis analysis NN cord-011793-hlktpla4 66 40 PROSEVA PROSEVA NNP cord-011793-hlktpla4 66 41 Study Study NNP cord-011793-hlktpla4 66 42 Group Group NNP cord-011793-hlktpla4 66 43 . . . cord-011793-hlktpla4 67 1 Prone prone JJ cord-011793-hlktpla4 67 2 positioning positioning NN cord-011793-hlktpla4 67 3 in in IN cord-011793-hlktpla4 67 4 severe severe JJ cord-011793-hlktpla4 67 5 acute acute JJ cord-011793-hlktpla4 67 6 respiratory respiratory JJ cord-011793-hlktpla4 67 7 distress distress NN cord-011793-hlktpla4 67 8 syndrome syndrome NN cord-011793-hlktpla4 67 9 National National NNP cord-011793-hlktpla4 67 10 Heart Heart NNP cord-011793-hlktpla4 67 11 , , , cord-011793-hlktpla4 67 12 Lung Lung NNP cord-011793-hlktpla4 67 13 , , , cord-011793-hlktpla4 67 14 and and CC cord-011793-hlktpla4 67 15 Blood Blood NNP cord-011793-hlktpla4 67 16 Institute Institute NNP cord-011793-hlktpla4 67 17 Acute Acute NNP cord-011793-hlktpla4 67 18 Respiratory Respiratory NNP cord-011793-hlktpla4 67 19 Distress Distress NNP cord-011793-hlktpla4 67 20 Syndrome Syndrome NNP cord-011793-hlktpla4 67 21 ( ( -LRB- cord-011793-hlktpla4 67 22 ARDS ARDS NNP cord-011793-hlktpla4 67 23 ) ) -RRB- cord-011793-hlktpla4 67 24 Clinical Clinical NNP cord-011793-hlktpla4 67 25 Trials Trials NNPS cord-011793-hlktpla4 67 26 Network Network NNP cord-011793-hlktpla4 67 27 . . . cord-011793-hlktpla4 68 1 Comparison comparison NN cord-011793-hlktpla4 68 2 of of IN cord-011793-hlktpla4 68 3 two two CD cord-011793-hlktpla4 68 4 fluid fluid JJ cord-011793-hlktpla4 68 5 - - HYPH cord-011793-hlktpla4 68 6 management management NN cord-011793-hlktpla4 68 7 strategies strategy NNS cord-011793-hlktpla4 68 8 in in IN cord-011793-hlktpla4 68 9 acute acute JJ cord-011793-hlktpla4 68 10 lung lung NN cord-011793-hlktpla4 68 11 injury injury NN cord-011793-hlktpla4 68 12 Efficacy Efficacy NNP cord-011793-hlktpla4 68 13 and and CC cord-011793-hlktpla4 68 14 safety safety NN cord-011793-hlktpla4 68 15 of of IN cord-011793-hlktpla4 68 16 a a DT cord-011793-hlktpla4 68 17 paired paired JJ cord-011793-hlktpla4 68 18 sedation sedation NN cord-011793-hlktpla4 68 19 and and CC cord-011793-hlktpla4 68 20 ventilator ventilator NN cord-011793-hlktpla4 68 21 weaning wean VBG cord-011793-hlktpla4 68 22 protocol protocol NN cord-011793-hlktpla4 68 23 for for IN cord-011793-hlktpla4 68 24 mechanically mechanically RB cord-011793-hlktpla4 68 25 ventilated ventilate VBN cord-011793-hlktpla4 68 26 patients patient NNS cord-011793-hlktpla4 68 27 in in IN cord-011793-hlktpla4 68 28 intensive intensive JJ cord-011793-hlktpla4 68 29 care care NN cord-011793-hlktpla4 68 30 ( ( -LRB- cord-011793-hlktpla4 68 31 Awakening Awakening NNP cord-011793-hlktpla4 68 32 and and CC cord-011793-hlktpla4 68 33 Breathing Breathing NNP cord-011793-hlktpla4 68 34 Controlled Controlled NNP cord-011793-hlktpla4 68 35 trial trial NN cord-011793-hlktpla4 68 36 ) ) -RRB- cord-011793-hlktpla4 68 37 : : : cord-011793-hlktpla4 68 38 a a DT cord-011793-hlktpla4 68 39 randomised randomised JJ cord-011793-hlktpla4 68 40 controlled control VBN cord-011793-hlktpla4 68 41 trial trial NN cord-011793-hlktpla4 68 42 An an DT cord-011793-hlktpla4 68 43 intervention intervention NN cord-011793-hlktpla4 68 44 to to TO cord-011793-hlktpla4 68 45 decrease decrease VB cord-011793-hlktpla4 68 46 catheter catheter NN cord-011793-hlktpla4 68 47 - - HYPH cord-011793-hlktpla4 68 48 related relate VBN cord-011793-hlktpla4 68 49 bloodstream bloodstream NN cord-011793-hlktpla4 68 50 infections infection NNS cord-011793-hlktpla4 68 51 in in IN cord-011793-hlktpla4 68 52 the the DT cord-011793-hlktpla4 68 53 ICU ICU NNP cord-011793-hlktpla4 68 54 Pragmatic pragmatic JJ cord-011793-hlktpla4 68 55 recommendations recommendation NNS cord-011793-hlktpla4 68 56 for for IN cord-011793-hlktpla4 68 57 intubating intubate VBG cord-011793-hlktpla4 68 58 critically critically RB cord-011793-hlktpla4 68 59 ill ill JJ cord-011793-hlktpla4 68 60 patients patient NNS cord-011793-hlktpla4 68 61 with with IN cord-011793-hlktpla4 68 62 suspected suspect VBN cord-011793-hlktpla4 68 63 COVID-19 COVID-19 NNP cord-011793-hlktpla4 68 64 Surviving Surviving NNP cord-011793-hlktpla4 68 65 sepsis sepsis NN cord-011793-hlktpla4 68 66 campaign campaign NN cord-011793-hlktpla4 68 67 : : : cord-011793-hlktpla4 68 68 guidelines guideline NNS cord-011793-hlktpla4 68 69 on on IN cord-011793-hlktpla4 68 70 the the DT cord-011793-hlktpla4 68 71 management management NN cord-011793-hlktpla4 68 72 of of IN cord-011793-hlktpla4 68 73 critically critically RB cord-011793-hlktpla4 68 74 ill ill JJ cord-011793-hlktpla4 68 75 adults adult NNS cord-011793-hlktpla4 68 76 with with IN cord-011793-hlktpla4 68 77 coronavirus coronavirus NN cord-011793-hlktpla4 68 78 disease disease NN cord-011793-hlktpla4 68 79 2019 2019 CD cord-011793-hlktpla4 68 80 ( ( -LRB- cord-011793-hlktpla4 68 81 COVID-19 COVID-19 NNP cord-011793-hlktpla4 68 82 ) ) -RRB- cord-011793-hlktpla4 68 83 Australian australian JJ cord-011793-hlktpla4 68 84 and and CC cord-011793-hlktpla4 68 85 New New NNP cord-011793-hlktpla4 68 86 Zealand Zealand NNP cord-011793-hlktpla4 68 87 Intensive Intensive NNP cord-011793-hlktpla4 68 88 Care Care NNP cord-011793-hlktpla4 68 89 Society Society NNP cord-011793-hlktpla4 68 90 . . . cord-011793-hlktpla4 69 1 ANZICS ANZICS NNP cord-011793-hlktpla4 70 1 COVID-19 COVID-19 NNP cord-011793-hlktpla4 70 2 Guidelines Guidelines NNPS cord-011793-hlktpla4 70 3 . . . cord-011793-hlktpla4 71 1 Melbourne Melbourne NNP cord-011793-hlktpla4 71 2 : : : cord-011793-hlktpla4 71 3 ANZICS anzic NNS cord-011793-hlktpla4 71 4 ; ; : cord-011793-hlktpla4 71 5 2020 2020 CD cord-011793-hlktpla4 71 6 High high JJ cord-011793-hlktpla4 71 7 - - HYPH cord-011793-hlktpla4 71 8 flow flow NN cord-011793-hlktpla4 71 9 oxygen oxygen NN cord-011793-hlktpla4 71 10 through through IN cord-011793-hlktpla4 71 11 nasal nasal NN cord-011793-hlktpla4 71 12 cannula cannula NN cord-011793-hlktpla4 71 13 in in IN cord-011793-hlktpla4 71 14 acute acute JJ cord-011793-hlktpla4 71 15 hypoxemic hypoxemic NN cord-011793-hlktpla4 72 1 respiratory respiratory JJ cord-011793-hlktpla4 72 2 failure failure NN cord-011793-hlktpla4 73 1 Author author NN cord-011793-hlktpla4 73 2 disclosures disclosure NNS cord-011793-hlktpla4 73 3 are be VBP cord-011793-hlktpla4 73 4 available available JJ cord-011793-hlktpla4 73 5 with with IN cord-011793-hlktpla4 73 6 the the DT cord-011793-hlktpla4 73 7 text text NN cord-011793-hlktpla4 73 8 of of IN cord-011793-hlktpla4 73 9 this this DT cord-011793-hlktpla4 73 10 article article NN cord-011793-hlktpla4 73 11 at at IN cord-011793-hlktpla4 73 12 www.atsjournals.org www.atsjournals.org NN cord-011793-hlktpla4 73 13 . . .