id sid tid token lemma pos cord-347706-r0rs3ls1 1 1 key key JJ cord-347706-r0rs3ls1 1 2 : : : cord-347706-r0rs3ls1 1 3 cord-347706-r0rs3ls1 cord-347706-r0rs3ls1 NN cord-347706-r0rs3ls1 1 4 authors author NNS cord-347706-r0rs3ls1 1 5 : : : cord-347706-r0rs3ls1 1 6 Roberts Roberts NNP cord-347706-r0rs3ls1 1 7 , , , cord-347706-r0rs3ls1 1 8 Anjeanette Anjeanette NNP cord-347706-r0rs3ls1 1 9 ; ; . cord-347706-r0rs3ls1 2 1 Subbarao Subbarao NNP cord-347706-r0rs3ls1 2 2 , , , cord-347706-r0rs3ls1 2 3 Kanta Kanta NNP cord-347706-r0rs3ls1 2 4 title title NN cord-347706-r0rs3ls1 2 5 : : : cord-347706-r0rs3ls1 2 6 Animal Animal NNP cord-347706-r0rs3ls1 2 7 Models Models NNPS cord-347706-r0rs3ls1 2 8 for for IN cord-347706-r0rs3ls1 2 9 Sars Sars NNP cord-347706-r0rs3ls1 2 10 date date NN cord-347706-r0rs3ls1 2 11 : : : cord-347706-r0rs3ls1 2 12 2006 2006 CD cord-347706-r0rs3ls1 2 13 journal journal NNP cord-347706-r0rs3ls1 2 14 : : : cord-347706-r0rs3ls1 3 1 The the DT cord-347706-r0rs3ls1 3 2 Nidoviruses Nidoviruses NNP cord-347706-r0rs3ls1 3 3 DOI DOI NNP cord-347706-r0rs3ls1 3 4 : : : cord-347706-r0rs3ls1 3 5 10.1007/978 10.1007/978 CD cord-347706-r0rs3ls1 3 6 - - HYPH cord-347706-r0rs3ls1 3 7 0 0 CD cord-347706-r0rs3ls1 3 8 - - HYPH cord-347706-r0rs3ls1 3 9 387 387 CD cord-347706-r0rs3ls1 3 10 - - HYPH cord-347706-r0rs3ls1 3 11 33012 33012 CD cord-347706-r0rs3ls1 3 12 - - HYPH cord-347706-r0rs3ls1 3 13 9_83 9_83 CD cord-347706-r0rs3ls1 3 14 sha sha NNP cord-347706-r0rs3ls1 3 15 : : : cord-347706-r0rs3ls1 3 16 1f592973f6d760c82d9b063ae6eb67615bdf9764 1f592973f6d760c82d9b063ae6eb67615bdf9764 CD cord-347706-r0rs3ls1 3 17 doc_id doc_id CD cord-347706-r0rs3ls1 3 18 : : : cord-347706-r0rs3ls1 3 19 347706 347706 CD cord-347706-r0rs3ls1 3 20 cord_uid cord_uid NNS cord-347706-r0rs3ls1 3 21 : : : cord-347706-r0rs3ls1 4 1 r0rs3ls1 r0rs3ls1 NNP cord-347706-r0rs3ls1 4 2 nan nan NNP cord-347706-r0rs3ls1 5 1 In in IN cord-347706-r0rs3ls1 5 2 2002 2002 CD cord-347706-r0rs3ls1 5 3 - - SYM cord-347706-r0rs3ls1 5 4 2003 2003 CD cord-347706-r0rs3ls1 5 5 , , , cord-347706-r0rs3ls1 5 6 severe severe JJ cord-347706-r0rs3ls1 5 7 acute acute JJ cord-347706-r0rs3ls1 5 8 respiratory respiratory JJ cord-347706-r0rs3ls1 5 9 syndrome syndrome NN cord-347706-r0rs3ls1 5 10 ( ( -LRB- cord-347706-r0rs3ls1 5 11 SARS SARS NNP cord-347706-r0rs3ls1 5 12 ) ) -RRB- cord-347706-r0rs3ls1 5 13 was be VBD cord-347706-r0rs3ls1 5 14 a a DT cord-347706-r0rs3ls1 5 15 newly newly RB cord-347706-r0rs3ls1 5 16 identified identify VBN cord-347706-r0rs3ls1 5 17 illness illness NN cord-347706-r0rs3ls1 5 18 that that WDT cord-347706-r0rs3ls1 5 19 emerged emerge VBD cord-347706-r0rs3ls1 5 20 in in IN cord-347706-r0rs3ls1 5 21 Southern Southern NNP cord-347706-r0rs3ls1 5 22 China China NNP cord-347706-r0rs3ls1 5 23 , , , cord-347706-r0rs3ls1 5 24 spread spread VBD cord-347706-r0rs3ls1 5 25 to to TO cord-347706-r0rs3ls1 5 26 involve involve VB cord-347706-r0rs3ls1 5 27 more more JJR cord-347706-r0rs3ls1 5 28 than than IN cord-347706-r0rs3ls1 5 29 30 30 CD cord-347706-r0rs3ls1 5 30 countries country NNS cord-347706-r0rs3ls1 5 31 , , , cord-347706-r0rs3ls1 5 32 and and CC cord-347706-r0rs3ls1 5 33 affected affect VBD cord-347706-r0rs3ls1 5 34 more more JJR cord-347706-r0rs3ls1 5 35 than than IN cord-347706-r0rs3ls1 5 36 8000 8000 CD cord-347706-r0rs3ls1 5 37 people people NNS cord-347706-r0rs3ls1 5 38 and and CC cord-347706-r0rs3ls1 5 39 caused cause VBD cord-347706-r0rs3ls1 5 40 nearly nearly RB cord-347706-r0rs3ls1 5 41 800 800 CD cord-347706-r0rs3ls1 5 42 deaths death NNS cord-347706-r0rs3ls1 5 43 worldwide worldwide RB cord-347706-r0rs3ls1 5 44 . . . cord-347706-r0rs3ls1 6 1 Although although IN cord-347706-r0rs3ls1 6 2 the the DT cord-347706-r0rs3ls1 6 3 etiologic etiologic JJ cord-347706-r0rs3ls1 6 4 agent agent NN cord-347706-r0rs3ls1 6 5 was be VBD cord-347706-r0rs3ls1 6 6 rapidly rapidly RB cord-347706-r0rs3ls1 6 7 identified identify VBN cord-347706-r0rs3ls1 6 8 to to TO cord-347706-r0rs3ls1 6 9 be be VB cord-347706-r0rs3ls1 6 10 a a DT cord-347706-r0rs3ls1 6 11 previously previously RB cord-347706-r0rs3ls1 6 12 unknown unknown JJ cord-347706-r0rs3ls1 6 13 coronavirus coronavirus NN cord-347706-r0rs3ls1 6 14 ( ( -LRB- cord-347706-r0rs3ls1 6 15 named name VBN cord-347706-r0rs3ls1 6 16 SARS SARS NNP cord-347706-r0rs3ls1 6 17 coronavirus coronavirus NN cord-347706-r0rs3ls1 6 18 or or CC cord-347706-r0rs3ls1 6 19 SARS SARS NNP cord-347706-r0rs3ls1 6 20 - - HYPH cord-347706-r0rs3ls1 6 21 CoV CoV NNP cord-347706-r0rs3ls1 6 22 ) ) -RRB- cord-347706-r0rs3ls1 6 23 and and CC cord-347706-r0rs3ls1 6 24 the the DT cord-347706-r0rs3ls1 6 25 outbreak outbreak NN cord-347706-r0rs3ls1 6 26 was be VBD cord-347706-r0rs3ls1 6 27 controlled control VBN cord-347706-r0rs3ls1 6 28 by by IN cord-347706-r0rs3ls1 6 29 public public JJ cord-347706-r0rs3ls1 6 30 health health NN cord-347706-r0rs3ls1 6 31 measures measure NNS cord-347706-r0rs3ls1 6 32 , , , cord-347706-r0rs3ls1 6 33 no no DT cord-347706-r0rs3ls1 6 34 specific specific JJ cord-347706-r0rs3ls1 6 35 options option NNS cord-347706-r0rs3ls1 6 36 were be VBD cord-347706-r0rs3ls1 6 37 available available JJ cord-347706-r0rs3ls1 6 38 for for IN cord-347706-r0rs3ls1 6 39 prevention prevention NN cord-347706-r0rs3ls1 6 40 and and CC cord-347706-r0rs3ls1 6 41 control control NN cord-347706-r0rs3ls1 6 42 of of IN cord-347706-r0rs3ls1 6 43 human human JJ cord-347706-r0rs3ls1 6 44 disease disease NN cord-347706-r0rs3ls1 6 45 . . . cord-347706-r0rs3ls1 7 1 Over over IN cord-347706-r0rs3ls1 7 2 the the DT cord-347706-r0rs3ls1 7 3 past past JJ cord-347706-r0rs3ls1 7 4 two two CD cord-347706-r0rs3ls1 7 5 years year NNS cord-347706-r0rs3ls1 7 6 , , , cord-347706-r0rs3ls1 7 7 a a DT cord-347706-r0rs3ls1 7 8 number number NN cord-347706-r0rs3ls1 7 9 of of IN cord-347706-r0rs3ls1 7 10 strategies strategy NNS cord-347706-r0rs3ls1 7 11 for for IN cord-347706-r0rs3ls1 7 12 vaccines vaccine NNS cord-347706-r0rs3ls1 7 13 and and CC cord-347706-r0rs3ls1 7 14 immunoprophylaxis immunoprophylaxis NNP cord-347706-r0rs3ls1 7 15 have have VBP cord-347706-r0rs3ls1 7 16 been be VBN cord-347706-r0rs3ls1 7 17 investigated investigate VBN cord-347706-r0rs3ls1 7 18 . . . cord-347706-r0rs3ls1 8 1 Animal animal NN cord-347706-r0rs3ls1 8 2 models model NNS cord-347706-r0rs3ls1 8 3 are be VBP cord-347706-r0rs3ls1 8 4 essential essential JJ cord-347706-r0rs3ls1 8 5 for for IN cord-347706-r0rs3ls1 8 6 preclinical preclinical JJ cord-347706-r0rs3ls1 8 7 evaluation evaluation NN cord-347706-r0rs3ls1 8 8 of of IN cord-347706-r0rs3ls1 8 9 the the DT cord-347706-r0rs3ls1 8 10 efficacy efficacy NN cord-347706-r0rs3ls1 8 11 of of IN cord-347706-r0rs3ls1 8 12 candidate candidate NN cord-347706-r0rs3ls1 8 13 vaccines vaccine NNS cord-347706-r0rs3ls1 8 14 and and CC cord-347706-r0rs3ls1 8 15 antivirals antiviral NNS cord-347706-r0rs3ls1 8 16 , , , cord-347706-r0rs3ls1 8 17 and and CC cord-347706-r0rs3ls1 8 18 they -PRON- PRP cord-347706-r0rs3ls1 8 19 are be VBP cord-347706-r0rs3ls1 8 20 also also RB cord-347706-r0rs3ls1 8 21 needed need VBN cord-347706-r0rs3ls1 8 22 in in IN cord-347706-r0rs3ls1 8 23 order order NN cord-347706-r0rs3ls1 8 24 to to TO cord-347706-r0rs3ls1 8 25 understand understand VB cord-347706-r0rs3ls1 8 26 the the DT cord-347706-r0rs3ls1 8 27 pathogenesis pathogenesis NN cord-347706-r0rs3ls1 8 28 of of IN cord-347706-r0rs3ls1 8 29 SARS SARS NNP cord-347706-r0rs3ls1 8 30 . . . cord-347706-r0rs3ls1 9 1 A a DT cord-347706-r0rs3ls1 9 2 number number NN cord-347706-r0rs3ls1 9 3 of of IN cord-347706-r0rs3ls1 9 4 investigators investigator NNS cord-347706-r0rs3ls1 9 5 around around IN cord-347706-r0rs3ls1 9 6 the the DT cord-347706-r0rs3ls1 9 7 world world NN cord-347706-r0rs3ls1 9 8 have have VBP cord-347706-r0rs3ls1 9 9 evaluated evaluate VBN cord-347706-r0rs3ls1 9 10 several several JJ cord-347706-r0rs3ls1 9 11 different different JJ cord-347706-r0rs3ls1 9 12 animal animal NN cord-347706-r0rs3ls1 9 13 species specie NNS cord-347706-r0rs3ls1 9 14 as as IN cord-347706-r0rs3ls1 9 15 models model NNS cord-347706-r0rs3ls1 9 16 for for IN cord-347706-r0rs3ls1 9 17 SARS SARS NNP cord-347706-r0rs3ls1 9 18 ; ; : cord-347706-r0rs3ls1 9 19 this this DT cord-347706-r0rs3ls1 9 20 effort effort NN cord-347706-r0rs3ls1 9 21 is be VBZ cord-347706-r0rs3ls1 9 22 important important JJ cord-347706-r0rs3ls1 9 23 for for IN cord-347706-r0rs3ls1 9 24 two two CD cord-347706-r0rs3ls1 9 25 natural natural JJ cord-347706-r0rs3ls1 9 26 reservoir reservoir NN cord-347706-r0rs3ls1 9 27 , , , cord-347706-r0rs3ls1 9 28 and and CC cord-347706-r0rs3ls1 9 29 second second JJ cord-347706-r0rs3ls1 9 30 , , , cord-347706-r0rs3ls1 9 31 if if IN cord-347706-r0rs3ls1 9 32 the the DT cord-347706-r0rs3ls1 9 33 efficacy efficacy NN cord-347706-r0rs3ls1 9 34 of of IN cord-347706-r0rs3ls1 9 35 vaccines vaccine NNS cord-347706-r0rs3ls1 9 36 can can MD cord-347706-r0rs3ls1 9 37 not not RB cord-347706-r0rs3ls1 9 38 be be VB cord-347706-r0rs3ls1 9 39 evaluated evaluate VBN cord-347706-r0rs3ls1 9 40 in in IN cord-347706-r0rs3ls1 9 41 humans human NNS cord-347706-r0rs3ls1 9 42 , , , cord-347706-r0rs3ls1 9 43 efficacy efficacy NN cord-347706-r0rs3ls1 9 44 in in IN cord-347706-r0rs3ls1 9 45 two two CD cord-347706-r0rs3ls1 9 46 or or CC cord-347706-r0rs3ls1 9 47 more more JJR cord-347706-r0rs3ls1 9 48 animal animal NN cord-347706-r0rs3ls1 9 49 models model NNS cord-347706-r0rs3ls1 9 50 may may MD cord-347706-r0rs3ls1 9 51 be be VB cord-347706-r0rs3ls1 9 52 required require VBN cord-347706-r0rs3ls1 9 53 for for IN cord-347706-r0rs3ls1 9 54 licensure licensure NN cord-347706-r0rs3ls1 9 55 . . . cord-347706-r0rs3ls1 10 1 The the DT cord-347706-r0rs3ls1 10 2 ideal ideal JJ cord-347706-r0rs3ls1 10 3 animal animal NN cord-347706-r0rs3ls1 10 4 models model NNS cord-347706-r0rs3ls1 10 5 would would MD cord-347706-r0rs3ls1 10 6 be be VB cord-347706-r0rs3ls1 10 7 those those DT cord-347706-r0rs3ls1 10 8 in in IN cord-347706-r0rs3ls1 10 9 which which WDT cord-347706-r0rs3ls1 10 10 viral viral JJ cord-347706-r0rs3ls1 10 11 replication replication NN cord-347706-r0rs3ls1 10 12 is be VBZ cord-347706-r0rs3ls1 10 13 accompanied accompany VBN cord-347706-r0rs3ls1 10 14 by by IN cord-347706-r0rs3ls1 10 15 clinical clinical JJ cord-347706-r0rs3ls1 10 16 illness illness NN cord-347706-r0rs3ls1 10 17 and and CC cord-347706-r0rs3ls1 10 18 pathology pathology NN cord-347706-r0rs3ls1 10 19 that that WDT cord-347706-r0rs3ls1 10 20 resembles resemble VBZ cord-347706-r0rs3ls1 10 21 that that DT cord-347706-r0rs3ls1 10 22 seen see VBN cord-347706-r0rs3ls1 10 23 in in IN cord-347706-r0rs3ls1 10 24 human human JJ cord-347706-r0rs3ls1 10 25 cases case NNS cord-347706-r0rs3ls1 10 26 of of IN cord-347706-r0rs3ls1 10 27 SARS SARS NNP cord-347706-r0rs3ls1 10 28 . . . cord-347706-r0rs3ls1 11 1 However however RB cord-347706-r0rs3ls1 11 2 , , , cord-347706-r0rs3ls1 11 3 the the DT cord-347706-r0rs3ls1 11 4 consequences consequence NNS cord-347706-r0rs3ls1 11 5 of of IN cord-347706-r0rs3ls1 11 6 SARS SARS NNP cord-347706-r0rs3ls1 11 7 - - HYPH cord-347706-r0rs3ls1 11 8 CoV CoV NNP cord-347706-r0rs3ls1 11 9 infection infection NN cord-347706-r0rs3ls1 11 10 in in IN cord-347706-r0rs3ls1 11 11 different different JJ cord-347706-r0rs3ls1 11 12 animal animal NN cord-347706-r0rs3ls1 11 13 models model NNS cord-347706-r0rs3ls1 11 14 may may MD cord-347706-r0rs3ls1 11 15 vary vary VB cord-347706-r0rs3ls1 11 16 from from IN cord-347706-r0rs3ls1 11 17 this this DT cord-347706-r0rs3ls1 11 18 picture picture NN cord-347706-r0rs3ls1 11 19 to to IN cord-347706-r0rs3ls1 11 20 one one CD cord-347706-r0rs3ls1 11 21 in in IN cord-347706-r0rs3ls1 11 22 which which WDT cord-347706-r0rs3ls1 11 23 viral viral JJ cord-347706-r0rs3ls1 11 24 replication replication NN cord-347706-r0rs3ls1 11 25 is be VBZ cord-347706-r0rs3ls1 11 26 associated associate VBN cord-347706-r0rs3ls1 11 27 with with IN cord-347706-r0rs3ls1 11 28 pathology pathology NN cord-347706-r0rs3ls1 11 29 in in IN cord-347706-r0rs3ls1 11 30 the the DT cord-347706-r0rs3ls1 11 31 absence absence NN cord-347706-r0rs3ls1 11 32 of of IN cord-347706-r0rs3ls1 11 33 clinical clinical JJ cord-347706-r0rs3ls1 11 34 illness illness NN cord-347706-r0rs3ls1 11 35 or or CC cord-347706-r0rs3ls1 11 36 models model NNS cord-347706-r0rs3ls1 11 37 in in IN cord-347706-r0rs3ls1 11 38 which which WDT cord-347706-r0rs3ls1 11 39 viral viral JJ cord-347706-r0rs3ls1 11 40 replication replication NN cord-347706-r0rs3ls1 11 41 is be VBZ cord-347706-r0rs3ls1 11 42 present present JJ cord-347706-r0rs3ls1 11 43 in in IN cord-347706-r0rs3ls1 11 44 the the DT cord-347706-r0rs3ls1 11 45 absence absence NN cord-347706-r0rs3ls1 11 46 of of IN cord-347706-r0rs3ls1 11 47 clinical clinical JJ cord-347706-r0rs3ls1 11 48 illness illness NN cord-347706-r0rs3ls1 11 49 or or CC cord-347706-r0rs3ls1 11 50 histopathologic histopathologic JJ cord-347706-r0rs3ls1 11 51 changes change NNS cord-347706-r0rs3ls1 11 52 . . . cord-347706-r0rs3ls1 12 1 Models model NNS cord-347706-r0rs3ls1 12 2 that that WDT cord-347706-r0rs3ls1 12 3 demonstrate demonstrate VBP cord-347706-r0rs3ls1 12 4 clinical clinical JJ cord-347706-r0rs3ls1 12 5 illness illness NN cord-347706-r0rs3ls1 12 6 and and CC cord-347706-r0rs3ls1 12 7 pathology pathology NN cord-347706-r0rs3ls1 12 8 can can MD cord-347706-r0rs3ls1 12 9 be be VB cord-347706-r0rs3ls1 12 10 used use VBN cord-347706-r0rs3ls1 12 11 to to TO cord-347706-r0rs3ls1 12 12 study study VB cord-347706-r0rs3ls1 12 13 the the DT cord-347706-r0rs3ls1 12 14 disease disease NN cord-347706-r0rs3ls1 12 15 process process NN cord-347706-r0rs3ls1 12 16 as as RB cord-347706-r0rs3ls1 12 17 well well RB cord-347706-r0rs3ls1 12 18 as as IN cord-347706-r0rs3ls1 12 19 to to TO cord-347706-r0rs3ls1 12 20 evaluate evaluate VB cord-347706-r0rs3ls1 12 21 intervention intervention NN cord-347706-r0rs3ls1 12 22 strategies strategy NNS cord-347706-r0rs3ls1 12 23 while while IN cord-347706-r0rs3ls1 12 24 models model NNS cord-347706-r0rs3ls1 12 25 in in IN cord-347706-r0rs3ls1 12 26 which which WDT cord-347706-r0rs3ls1 12 27 virus virus NN cord-347706-r0rs3ls1 12 28 replication replication NN cord-347706-r0rs3ls1 12 29 occurs occur VBZ cord-347706-r0rs3ls1 12 30 without without IN cord-347706-r0rs3ls1 12 31 clinical clinical JJ cord-347706-r0rs3ls1 12 32 illness illness NN cord-347706-r0rs3ls1 12 33 can can MD cord-347706-r0rs3ls1 12 34 be be VB cord-347706-r0rs3ls1 12 35 used use VBN cord-347706-r0rs3ls1 12 36 in in IN cord-347706-r0rs3ls1 12 37 vaccine vaccine NN cord-347706-r0rs3ls1 12 38 or or CC cord-347706-r0rs3ls1 12 39 antiviral antiviral JJ cord-347706-r0rs3ls1 12 40 studies study NNS cord-347706-r0rs3ls1 12 41 . . . cord-347706-r0rs3ls1 13 1 In in IN cord-347706-r0rs3ls1 13 2 these these DT cord-347706-r0rs3ls1 13 3 cases case NNS cord-347706-r0rs3ls1 13 4 , , , cord-347706-r0rs3ls1 13 5 the the DT cord-347706-r0rs3ls1 13 6 efficacy efficacy NN cord-347706-r0rs3ls1 13 7 of of IN cord-347706-r0rs3ls1 13 8 an an DT cord-347706-r0rs3ls1 13 9 intervention intervention NN cord-347706-r0rs3ls1 13 10 can can MD cord-347706-r0rs3ls1 13 11 be be VB cord-347706-r0rs3ls1 13 12 assessed assess VBN cord-347706-r0rs3ls1 13 13 by by IN cord-347706-r0rs3ls1 13 14 quantitative quantitative JJ cord-347706-r0rs3ls1 13 15 virology virology NN cord-347706-r0rs3ls1 13 16 with with IN cord-347706-r0rs3ls1 13 17 or or CC cord-347706-r0rs3ls1 13 18 without without IN cord-347706-r0rs3ls1 13 19 accompanying accompany VBG cord-347706-r0rs3ls1 13 20 pathology pathology NN cord-347706-r0rs3ls1 13 21 . . . cord-347706-r0rs3ls1 14 1 A a DT cord-347706-r0rs3ls1 14 2 review review NN cord-347706-r0rs3ls1 14 3 of of IN cord-347706-r0rs3ls1 14 4 the the DT cord-347706-r0rs3ls1 14 5 different different JJ cord-347706-r0rs3ls1 14 6 animal animal NN cord-347706-r0rs3ls1 14 7 models model NNS cord-347706-r0rs3ls1 14 8 that that WDT cord-347706-r0rs3ls1 14 9 have have VBP cord-347706-r0rs3ls1 14 10 been be VBN cord-347706-r0rs3ls1 14 11 reported report VBN cord-347706-r0rs3ls1 14 12 follows follow VBZ cord-347706-r0rs3ls1 14 13 with with IN cord-347706-r0rs3ls1 14 14 a a DT cord-347706-r0rs3ls1 14 15 summary summary NN cord-347706-r0rs3ls1 14 16 of of IN cord-347706-r0rs3ls1 14 17 the the DT cord-347706-r0rs3ls1 14 18 pros pro NNS cord-347706-r0rs3ls1 14 19 and and CC cord-347706-r0rs3ls1 14 20 cons con NNS cord-347706-r0rs3ls1 14 21 and and CC cord-347706-r0rs3ls1 14 22 potential potential JJ cord-347706-r0rs3ls1 14 23 applications application NNS cord-347706-r0rs3ls1 14 24 of of IN cord-347706-r0rs3ls1 14 25 the the DT cord-347706-r0rs3ls1 14 26 different different JJ cord-347706-r0rs3ls1 14 27 models model NNS cord-347706-r0rs3ls1 14 28 . . . cord-347706-r0rs3ls1 14 29 _SP cord-347706-r0rs3ls1 15 1 CoV CoV NNP cord-347706-r0rs3ls1 15 2 intranasally intranasally RB cord-347706-r0rs3ls1 15 3 ( ( -LRB- cord-347706-r0rs3ls1 15 4 i.n i.n NNP cord-347706-r0rs3ls1 15 5 . . NNP cord-347706-r0rs3ls1 15 6 ) ) -RRB- cord-347706-r0rs3ls1 15 7 , , , cord-347706-r0rs3ls1 15 8 the the DT cord-347706-r0rs3ls1 15 9 virus virus NN cord-347706-r0rs3ls1 15 10 replicates replicate VBZ cord-347706-r0rs3ls1 15 11 efficiently efficiently RB cord-347706-r0rs3ls1 15 12 in in IN cord-347706-r0rs3ls1 15 13 the the DT cord-347706-r0rs3ls1 15 14 respiratory respiratory JJ cord-347706-r0rs3ls1 15 15 tract tract NN cord-347706-r0rs3ls1 15 16 ( ( -LRB- cord-347706-r0rs3ls1 15 17 lungs lung NNS cord-347706-r0rs3ls1 15 18 and and CC cord-347706-r0rs3ls1 15 19 nasal nasal NN cord-347706-r0rs3ls1 15 20 turbinates turbinate NNS cord-347706-r0rs3ls1 15 21 ) ) -RRB- cord-347706-r0rs3ls1 15 22 with with IN cord-347706-r0rs3ls1 15 23 a a DT cord-347706-r0rs3ls1 15 24 peak peak NN cord-347706-r0rs3ls1 15 25 of of IN cord-347706-r0rs3ls1 15 26 viral viral JJ cord-347706-r0rs3ls1 15 27 replication replication NN cord-347706-r0rs3ls1 15 28 on on IN cord-347706-r0rs3ls1 15 29 day day NN cord-347706-r0rs3ls1 15 30 2 2 CD cord-347706-r0rs3ls1 15 31 postinfection postinfection NN cord-347706-r0rs3ls1 15 32 ( ( -LRB- cord-347706-r0rs3ls1 15 33 mean mean VB cord-347706-r0rs3ls1 15 34 titer titer NN cord-347706-r0rs3ls1 15 35 in in IN cord-347706-r0rs3ls1 15 36 lungs lung NNS cord-347706-r0rs3ls1 15 37 is be VBZ cord-347706-r0rs3ls1 15 38 10 10 CD cord-347706-r0rs3ls1 15 39 6 6 CD cord-347706-r0rs3ls1 15 40 to to TO cord-347706-r0rs3ls1 15 41 10 10 CD cord-347706-r0rs3ls1 15 42 7 7 CD cord-347706-r0rs3ls1 15 43 50 50 CD cord-347706-r0rs3ls1 15 44 % % NN cord-347706-r0rs3ls1 15 45 tissue tissue NN cord-347706-r0rs3ls1 15 46 culture culture NN cord-347706-r0rs3ls1 15 47 infectious infectious JJ cord-347706-r0rs3ls1 15 48 doses dose NNS cord-347706-r0rs3ls1 15 49 ( ( -LRB- cord-347706-r0rs3ls1 15 50 TCID TCID NNP cord-347706-r0rs3ls1 15 51 50 50 CD cord-347706-r0rs3ls1 15 52 ) ) -RRB- cord-347706-r0rs3ls1 15 53 per per IN cord-347706-r0rs3ls1 15 54 gram gram NN cord-347706-r0rs3ls1 15 55 and and CC cord-347706-r0rs3ls1 15 56 mean mean VB cord-347706-r0rs3ls1 15 57 titer titer NN cord-347706-r0rs3ls1 15 58 in in IN cord-347706-r0rs3ls1 15 59 nasal nasal NN cord-347706-r0rs3ls1 15 60 turbinates turbinate NNS cord-347706-r0rs3ls1 15 61 is be VBZ cord-347706-r0rs3ls1 15 62 10 10 CD cord-347706-r0rs3ls1 15 63 5 5 CD cord-347706-r0rs3ls1 15 64 to to TO cord-347706-r0rs3ls1 15 65 10 10 CD cord-347706-r0rs3ls1 15 66 6 6 CD cord-347706-r0rs3ls1 15 67 TCID TCID NNP cord-347706-r0rs3ls1 15 68 50 50 CD cord-347706-r0rs3ls1 15 69 per per IN cord-347706-r0rs3ls1 15 70 gram gram NN cord-347706-r0rs3ls1 15 71 following follow VBG cord-347706-r0rs3ls1 15 72 administration administration NN cord-347706-r0rs3ls1 15 73 of of IN cord-347706-r0rs3ls1 15 74 10 10 CD cord-347706-r0rs3ls1 15 75 6 6 CD cord-347706-r0rs3ls1 15 76 TCID TCID NNP cord-347706-r0rs3ls1 15 77 50 50 CD cord-347706-r0rs3ls1 15 78 of of IN cord-347706-r0rs3ls1 15 79 SARS SARS NNP cord-347706-r0rs3ls1 15 80 - - HYPH cord-347706-r0rs3ls1 15 81 CoV CoV NNP cord-347706-r0rs3ls1 15 82 i.n i.n NNP cord-347706-r0rs3ls1 15 83 . . NNP cord-347706-r0rs3ls1 15 84 ) ) -RRB- cord-347706-r0rs3ls1 15 85 . . . cord-347706-r0rs3ls1 16 1 1 1 LS cord-347706-r0rs3ls1 16 2 Virus virus NN cord-347706-r0rs3ls1 16 3 is be VBZ cord-347706-r0rs3ls1 16 4 cleared clear VBN cord-347706-r0rs3ls1 16 5 from from IN cord-347706-r0rs3ls1 16 6 the the DT cord-347706-r0rs3ls1 16 7 respiratory respiratory JJ cord-347706-r0rs3ls1 16 8 tract tract NN cord-347706-r0rs3ls1 16 9 by by IN cord-347706-r0rs3ls1 16 10 about about IN cord-347706-r0rs3ls1 16 11 day day NN cord-347706-r0rs3ls1 16 12 5 5 CD cord-347706-r0rs3ls1 16 13 . . . cord-347706-r0rs3ls1 17 1 Virus virus NN cord-347706-r0rs3ls1 17 2 replication replication NN cord-347706-r0rs3ls1 17 3 occurs occur VBZ cord-347706-r0rs3ls1 17 4 without without IN cord-347706-r0rs3ls1 17 5 signs sign NNS cord-347706-r0rs3ls1 17 6 of of IN cord-347706-r0rs3ls1 17 7 illness illness NN cord-347706-r0rs3ls1 17 8 such such JJ cord-347706-r0rs3ls1 17 9 as as IN cord-347706-r0rs3ls1 17 10 weight weight NN cord-347706-r0rs3ls1 17 11 loss loss NN cord-347706-r0rs3ls1 17 12 or or CC cord-347706-r0rs3ls1 17 13 ruffled ruffled JJ cord-347706-r0rs3ls1 17 14 fur fur NN cord-347706-r0rs3ls1 17 15 and and CC cord-347706-r0rs3ls1 17 16 is be VBZ cord-347706-r0rs3ls1 17 17 associated associate VBN cord-347706-r0rs3ls1 17 18 with with IN cord-347706-r0rs3ls1 17 19 minimal minimal JJ cord-347706-r0rs3ls1 17 20 to to IN cord-347706-r0rs3ls1 17 21 mild mild JJ cord-347706-r0rs3ls1 17 22 inflammation inflammation NN cord-347706-r0rs3ls1 17 23 in in IN cord-347706-r0rs3ls1 17 24 the the DT cord-347706-r0rs3ls1 17 25 lungs lung NNS cord-347706-r0rs3ls1 17 26 . . . cord-347706-r0rs3ls1 18 1 Viral viral JJ cord-347706-r0rs3ls1 18 2 antigen antigen NN cord-347706-r0rs3ls1 18 3 and and CC cord-347706-r0rs3ls1 18 4 nucleic nucleic JJ cord-347706-r0rs3ls1 18 5 acid acid NN cord-347706-r0rs3ls1 18 6 are be VBP cord-347706-r0rs3ls1 18 7 present present JJ cord-347706-r0rs3ls1 18 8 in in IN cord-347706-r0rs3ls1 18 9 the the DT cord-347706-r0rs3ls1 18 10 epithelial epithelial JJ cord-347706-r0rs3ls1 18 11 cells cell NNS cord-347706-r0rs3ls1 18 12 of of IN cord-347706-r0rs3ls1 18 13 the the DT cord-347706-r0rs3ls1 18 14 large large JJ cord-347706-r0rs3ls1 18 15 airways airway NNS cord-347706-r0rs3ls1 18 16 on on IN cord-347706-r0rs3ls1 18 17 day day NN cord-347706-r0rs3ls1 18 18 2 2 CD cord-347706-r0rs3ls1 18 19 but but CC cord-347706-r0rs3ls1 18 20 are be VBP cord-347706-r0rs3ls1 18 21 being be VBG cord-347706-r0rs3ls1 18 22 cleared clear VBN cord-347706-r0rs3ls1 18 23 by by IN cord-347706-r0rs3ls1 18 24 day day NN cord-347706-r0rs3ls1 18 25 4 4 CD cord-347706-r0rs3ls1 18 26 . . . cord-347706-r0rs3ls1 19 1 1 1 LS cord-347706-r0rs3ls1 20 1 When when WRB cord-347706-r0rs3ls1 20 2 SARS SARS NNP cord-347706-r0rs3ls1 20 3 - - HYPH cord-347706-r0rs3ls1 20 4 CoV CoV NNP cord-347706-r0rs3ls1 20 5 is be VBZ cord-347706-r0rs3ls1 20 6 administered administer VBN cord-347706-r0rs3ls1 20 7 to to IN cord-347706-r0rs3ls1 20 8 BALB BALB NNP cord-347706-r0rs3ls1 20 9 / / SYM cord-347706-r0rs3ls1 20 10 c c NNP cord-347706-r0rs3ls1 20 11 mice mice NNP cord-347706-r0rs3ls1 20 12 i.n i.n NNP cord-347706-r0rs3ls1 20 13 . . . cord-347706-r0rs3ls1 21 1 and and CC cord-347706-r0rs3ls1 21 2 orally orally RB cord-347706-r0rs3ls1 21 3 , , , cord-347706-r0rs3ls1 21 4 viral viral JJ cord-347706-r0rs3ls1 21 5 nucleic nucleic JJ cord-347706-r0rs3ls1 21 6 acid acid NN cord-347706-r0rs3ls1 21 7 can can MD cord-347706-r0rs3ls1 21 8 be be VB cord-347706-r0rs3ls1 21 9 amplified amplify VBN cord-347706-r0rs3ls1 21 10 from from IN cord-347706-r0rs3ls1 21 11 lung lung NN cord-347706-r0rs3ls1 21 12 tissue tissue NN cord-347706-r0rs3ls1 21 13 and and CC cord-347706-r0rs3ls1 21 14 small small JJ cord-347706-r0rs3ls1 21 15 intestines intestine NNS cord-347706-r0rs3ls1 21 16 . . . cord-347706-r0rs3ls1 22 1 2 2 LS cord-347706-r0rs3ls1 23 1 Intranasally intranasally RB cord-347706-r0rs3ls1 23 2 administered administer VBN cord-347706-r0rs3ls1 23 3 SARS SARS NNP cord-347706-r0rs3ls1 23 4 - - HYPH cord-347706-r0rs3ls1 23 5 CoV CoV NNP cord-347706-r0rs3ls1 23 6 also also RB cord-347706-r0rs3ls1 23 7 replicates replicate VBZ cord-347706-r0rs3ls1 23 8 in in IN cord-347706-r0rs3ls1 23 9 the the DT cord-347706-r0rs3ls1 23 10 lungs lung NNS cord-347706-r0rs3ls1 23 11 of of IN cord-347706-r0rs3ls1 23 12 C57BL/6 C57BL/6 NNP cord-347706-r0rs3ls1 23 13 ( ( -LRB- cord-347706-r0rs3ls1 23 14 B6 b6 NN cord-347706-r0rs3ls1 23 15 ) ) -RRB- cord-347706-r0rs3ls1 23 16 mice mouse NNS cord-347706-r0rs3ls1 23 17 , , , cord-347706-r0rs3ls1 23 18 with with IN cord-347706-r0rs3ls1 23 19 a a DT cord-347706-r0rs3ls1 23 20 peak peak NN cord-347706-r0rs3ls1 23 21 of of IN cord-347706-r0rs3ls1 23 22 viral viral JJ cord-347706-r0rs3ls1 23 23 replication replication NN cord-347706-r0rs3ls1 23 24 on on IN cord-347706-r0rs3ls1 23 25 day day NN cord-347706-r0rs3ls1 23 26 3 3 CD cord-347706-r0rs3ls1 23 27 and and CC cord-347706-r0rs3ls1 23 28 clearance clearance NN cord-347706-r0rs3ls1 23 29 of of IN cord-347706-r0rs3ls1 23 30 virus virus NN cord-347706-r0rs3ls1 23 31 by by IN cord-347706-r0rs3ls1 23 32 day day NN cord-347706-r0rs3ls1 23 33 9 9 CD cord-347706-r0rs3ls1 23 34 . . . cord-347706-r0rs3ls1 24 1 3 3 CD cord-347706-r0rs3ls1 24 2 SARS SARS NNP cord-347706-r0rs3ls1 24 3 - - HYPH cord-347706-r0rs3ls1 24 4 CoV CoV NNP cord-347706-r0rs3ls1 24 5 infected infect VBN cord-347706-r0rs3ls1 25 1 BALB BALB NNP cord-347706-r0rs3ls1 25 2 / / SYM cord-347706-r0rs3ls1 25 3 c c NN cord-347706-r0rs3ls1 25 4 and and CC cord-347706-r0rs3ls1 25 5 B6 b6 NN cord-347706-r0rs3ls1 25 6 mice mouse NNS cord-347706-r0rs3ls1 25 7 tend tend VBP cord-347706-r0rs3ls1 25 8 to to TO cord-347706-r0rs3ls1 25 9 gain gain VB cord-347706-r0rs3ls1 25 10 less less JJR cord-347706-r0rs3ls1 25 11 weight weight NN cord-347706-r0rs3ls1 25 12 than than IN cord-347706-r0rs3ls1 25 13 mock mock JJ cord-347706-r0rs3ls1 25 14 - - HYPH cord-347706-r0rs3ls1 25 15 infected infected JJ cord-347706-r0rs3ls1 25 16 mice mouse NNS cord-347706-r0rs3ls1 25 17 2,3 2,3 CD cord-347706-r0rs3ls1 26 1 129SvEv 129svev CD cord-347706-r0rs3ls1 26 2 mice mouse NNS cord-347706-r0rs3ls1 26 3 also also RB cord-347706-r0rs3ls1 26 4 support support VBP cord-347706-r0rs3ls1 26 5 replication replication NN cord-347706-r0rs3ls1 26 6 of of IN cord-347706-r0rs3ls1 26 7 SARS SARS NNP cord-347706-r0rs3ls1 26 8 - - HYPH cord-347706-r0rs3ls1 26 9 CoV CoV NNP cord-347706-r0rs3ls1 26 10 with with IN cord-347706-r0rs3ls1 26 11 a a DT cord-347706-r0rs3ls1 26 12 self self NN cord-347706-r0rs3ls1 26 13 - - HYPH cord-347706-r0rs3ls1 26 14 limited limit VBN cord-347706-r0rs3ls1 26 15 bronchiolitis bronchiolitis NN cord-347706-r0rs3ls1 26 16 that that WDT cord-347706-r0rs3ls1 26 17 begins begin VBZ cord-347706-r0rs3ls1 26 18 with with IN cord-347706-r0rs3ls1 26 19 mixed mixed JJ cord-347706-r0rs3ls1 26 20 peribronchiolar peribronchiolar JJ cord-347706-r0rs3ls1 26 21 inflammatory inflammatory JJ cord-347706-r0rs3ls1 26 22 infiltrates infiltrate NNS cord-347706-r0rs3ls1 26 23 , , , cord-347706-r0rs3ls1 26 24 progresses progress VBZ cord-347706-r0rs3ls1 26 25 to to TO cord-347706-r0rs3ls1 26 26 bronchiolitis bronchiolitis VB cord-347706-r0rs3ls1 26 27 with with IN cord-347706-r0rs3ls1 26 28 migration migration NN cord-347706-r0rs3ls1 26 29 of of IN cord-347706-r0rs3ls1 26 30 inflammatory inflammatory JJ cord-347706-r0rs3ls1 26 31 cells cell NNS cord-347706-r0rs3ls1 26 32 into into IN cord-347706-r0rs3ls1 26 33 surface surface NN cord-347706-r0rs3ls1 26 34 epithelium epithelium NN cord-347706-r0rs3ls1 26 35 and and CC cord-347706-r0rs3ls1 26 36 interstitial interstitial JJ cord-347706-r0rs3ls1 26 37 inflammation inflammation NN cord-347706-r0rs3ls1 26 38 in in IN cord-347706-r0rs3ls1 26 39 adjacent adjacent JJ cord-347706-r0rs3ls1 26 40 alveolar alveolar NN cord-347706-r0rs3ls1 26 41 septae septae NN cord-347706-r0rs3ls1 26 42 , , , cord-347706-r0rs3ls1 26 43 that that WDT cord-347706-r0rs3ls1 26 44 resolves resolve VBZ cord-347706-r0rs3ls1 26 45 completely completely RB cord-347706-r0rs3ls1 26 46 over over IN cord-347706-r0rs3ls1 26 47 the the DT cord-347706-r0rs3ls1 26 48 next next JJ cord-347706-r0rs3ls1 26 49 2 2 CD cord-347706-r0rs3ls1 26 50 weeks week NNS cord-347706-r0rs3ls1 26 51 . . . cord-347706-r0rs3ls1 27 1 4 4 CD cord-347706-r0rs3ls1 27 2 SARS SARS NNP cord-347706-r0rs3ls1 27 3 - - HYPH cord-347706-r0rs3ls1 27 4 CoV CoV NNP cord-347706-r0rs3ls1 27 5 infected infect VBN cord-347706-r0rs3ls1 27 6 mice mouse NNS cord-347706-r0rs3ls1 27 7 develop develop VBP cord-347706-r0rs3ls1 27 8 a a DT cord-347706-r0rs3ls1 27 9 SARS SARS NNP cord-347706-r0rs3ls1 27 10 - - HYPH cord-347706-r0rs3ls1 27 11 CoV cov NN cord-347706-r0rs3ls1 27 12 specific specific JJ cord-347706-r0rs3ls1 27 13 neutralizing neutralize VBG cord-347706-r0rs3ls1 27 14 antibody antibody NN cord-347706-r0rs3ls1 27 15 response response NN cord-347706-r0rs3ls1 27 16 and and CC cord-347706-r0rs3ls1 27 17 are be VBP cord-347706-r0rs3ls1 27 18 protected protect VBN cord-347706-r0rs3ls1 27 19 from from IN cord-347706-r0rs3ls1 27 20 reinfection reinfection NN cord-347706-r0rs3ls1 27 21 with with IN cord-347706-r0rs3ls1 28 1 SARS SARS NNP cord-347706-r0rs3ls1 28 2 - - HYPH cord-347706-r0rs3ls1 28 3 CoV. CoV. NNP cord-347706-r0rs3ls1 28 4 Antibody Antibody NNP cord-347706-r0rs3ls1 28 5 alone alone RB cord-347706-r0rs3ls1 28 6 is be VBZ cord-347706-r0rs3ls1 28 7 sufficient sufficient JJ cord-347706-r0rs3ls1 28 8 to to TO cord-347706-r0rs3ls1 28 9 transfer transfer VB cord-347706-r0rs3ls1 28 10 this this DT cord-347706-r0rs3ls1 28 11 protection protection NN cord-347706-r0rs3ls1 28 12 to to IN cord-347706-r0rs3ls1 28 13 naïve naïve JJ cord-347706-r0rs3ls1 28 14 mice mouse NNS cord-347706-r0rs3ls1 28 15 . . . cord-347706-r0rs3ls1 29 1 1 1 LS cord-347706-r0rs3ls1 29 2 Mice mouse NNS cord-347706-r0rs3ls1 29 3 with with IN cord-347706-r0rs3ls1 29 4 targeted target VBN cord-347706-r0rs3ls1 29 5 defects defect NNS cord-347706-r0rs3ls1 29 6 in in IN cord-347706-r0rs3ls1 29 7 the the DT cord-347706-r0rs3ls1 29 8 immune immune JJ cord-347706-r0rs3ls1 29 9 system system NN cord-347706-r0rs3ls1 29 10 were be VBD cord-347706-r0rs3ls1 29 11 evaluated evaluate VBN cord-347706-r0rs3ls1 29 12 in in IN cord-347706-r0rs3ls1 29 13 order order NN cord-347706-r0rs3ls1 29 14 to to TO cord-347706-r0rs3ls1 29 15 determine determine VB cord-347706-r0rs3ls1 29 16 which which WDT cord-347706-r0rs3ls1 29 17 arm arm NN cord-347706-r0rs3ls1 29 18 of of IN cord-347706-r0rs3ls1 29 19 the the DT cord-347706-r0rs3ls1 29 20 immune immune JJ cord-347706-r0rs3ls1 29 21 system system NN cord-347706-r0rs3ls1 29 22 was be VBD cord-347706-r0rs3ls1 29 23 responsible responsible JJ cord-347706-r0rs3ls1 29 24 for for IN cord-347706-r0rs3ls1 29 25 clearance clearance NN cord-347706-r0rs3ls1 29 26 of of IN cord-347706-r0rs3ls1 29 27 SARS SARS NNP cord-347706-r0rs3ls1 29 28 - - HYPH cord-347706-r0rs3ls1 29 29 CoV CoV NNP cord-347706-r0rs3ls1 29 30 in in IN cord-347706-r0rs3ls1 29 31 mice mouse NNS cord-347706-r0rs3ls1 29 32 . . . cord-347706-r0rs3ls1 30 1 Beige Beige NNP cord-347706-r0rs3ls1 30 2 , , , cord-347706-r0rs3ls1 30 3 CD1 CD1 NNP cord-347706-r0rs3ls1 30 4 -/and -/and HYPH cord-347706-r0rs3ls1 30 5 RAG1 RAG1 NNPS cord-347706-r0rs3ls1 30 6 -/mice -/mice XX cord-347706-r0rs3ls1 30 7 replicated replicate VBN cord-347706-r0rs3ls1 30 8 and and CC cord-347706-r0rs3ls1 30 9 cleared clear VBD cord-347706-r0rs3ls1 30 10 virus virus NN cord-347706-r0rs3ls1 30 11 with with IN cord-347706-r0rs3ls1 30 12 the the DT cord-347706-r0rs3ls1 30 13 same same JJ cord-347706-r0rs3ls1 30 14 kinetics kinetic NNS cord-347706-r0rs3ls1 30 15 as as IN cord-347706-r0rs3ls1 30 16 B6 b6 NN cord-347706-r0rs3ls1 30 17 mice mouse NNS cord-347706-r0rs3ls1 30 18 , , , cord-347706-r0rs3ls1 30 19 without without IN cord-347706-r0rs3ls1 30 20 overt overt JJ cord-347706-r0rs3ls1 30 21 signs sign NNS cord-347706-r0rs3ls1 30 22 of of IN cord-347706-r0rs3ls1 30 23 clinical clinical JJ cord-347706-r0rs3ls1 30 24 disease disease NN cord-347706-r0rs3ls1 30 25 indicating indicate VBG cord-347706-r0rs3ls1 30 26 that that IN cord-347706-r0rs3ls1 30 27 NK NK NNP cord-347706-r0rs3ls1 30 28 cells cell NNS cord-347706-r0rs3ls1 30 29 , , , cord-347706-r0rs3ls1 30 30 NK NK NNP cord-347706-r0rs3ls1 30 31 - - HYPH cord-347706-r0rs3ls1 30 32 T T NNP cord-347706-r0rs3ls1 30 33 cells cell NNS cord-347706-r0rs3ls1 30 34 , , , cord-347706-r0rs3ls1 30 35 and and CC cord-347706-r0rs3ls1 30 36 T T NNP cord-347706-r0rs3ls1 30 37 and and CC cord-347706-r0rs3ls1 30 38 B b NN cord-347706-r0rs3ls1 30 39 lymphocytes lymphocyte NNS cord-347706-r0rs3ls1 30 40 are be VBP cord-347706-r0rs3ls1 30 41 not not RB cord-347706-r0rs3ls1 30 42 required require VBN cord-347706-r0rs3ls1 30 43 for for IN cord-347706-r0rs3ls1 30 44 clearance clearance NN cord-347706-r0rs3ls1 30 45 of of IN cord-347706-r0rs3ls1 30 46 SARS SARS NNP cord-347706-r0rs3ls1 30 47 - - HYPH cord-347706-r0rs3ls1 30 48 CoV CoV NNP cord-347706-r0rs3ls1 30 49 from from IN cord-347706-r0rs3ls1 30 50 the the DT cord-347706-r0rs3ls1 30 51 lungs lung NNS cord-347706-r0rs3ls1 30 52 of of IN cord-347706-r0rs3ls1 30 53 mice mouse NNS cord-347706-r0rs3ls1 30 54 . . . cord-347706-r0rs3ls1 31 1 3 3 LS cord-347706-r0rs3ls1 32 1 In in IN cord-347706-r0rs3ls1 32 2 young young JJ cord-347706-r0rs3ls1 32 3 mice mouse NNS cord-347706-r0rs3ls1 32 4 , , , cord-347706-r0rs3ls1 32 5 SARS SARS NNP cord-347706-r0rs3ls1 32 6 - - HYPH cord-347706-r0rs3ls1 32 7 CoV CoV NNP cord-347706-r0rs3ls1 32 8 induces induce VBZ cord-347706-r0rs3ls1 32 9 dramatic dramatic JJ cord-347706-r0rs3ls1 32 10 upregulation upregulation NN cord-347706-r0rs3ls1 32 11 of of IN cord-347706-r0rs3ls1 32 12 a a DT cord-347706-r0rs3ls1 32 13 subset subset NN cord-347706-r0rs3ls1 32 14 of of IN cord-347706-r0rs3ls1 32 15 inflammatory inflammatory JJ cord-347706-r0rs3ls1 32 16 chemokines chemokine NNS cord-347706-r0rs3ls1 32 17 ( ( -LRB- cord-347706-r0rs3ls1 32 18 CCL2 CCL2 NNP cord-347706-r0rs3ls1 32 19 , , , cord-347706-r0rs3ls1 32 20 CCL3 CCL3 NNP cord-347706-r0rs3ls1 32 21 , , , cord-347706-r0rs3ls1 32 22 CCL5 CCL5 NNP cord-347706-r0rs3ls1 32 23 , , , cord-347706-r0rs3ls1 32 24 CXCL9 CXCL9 NNP cord-347706-r0rs3ls1 32 25 , , , cord-347706-r0rs3ls1 32 26 CXCL10 CXCL10 NNP cord-347706-r0rs3ls1 32 27 ) ) -RRB- cord-347706-r0rs3ls1 32 28 and and CC cord-347706-r0rs3ls1 32 29 the the DT cord-347706-r0rs3ls1 32 30 chemokine chemokine NN cord-347706-r0rs3ls1 32 31 receptor receptor NN cord-347706-r0rs3ls1 32 32 CXCR3 cxcr3 XX cord-347706-r0rs3ls1 32 33 without without IN cord-347706-r0rs3ls1 32 34 detectable detectable JJ cord-347706-r0rs3ls1 32 35 expression expression NN cord-347706-r0rs3ls1 32 36 of of IN cord-347706-r0rs3ls1 32 37 classic classic JJ cord-347706-r0rs3ls1 32 38 proinflammatory proinflammatory JJ cord-347706-r0rs3ls1 32 39 and and CC cord-347706-r0rs3ls1 32 40 immunoregulatory immunoregulatory JJ cord-347706-r0rs3ls1 32 41 cytokines cytokine NNS cord-347706-r0rs3ls1 32 42 ( ( -LRB- cord-347706-r0rs3ls1 32 43 IFN IFN NNP cord-347706-r0rs3ls1 32 44 - - HYPH cord-347706-r0rs3ls1 32 45 γ γ NNP cord-347706-r0rs3ls1 32 46 , , , cord-347706-r0rs3ls1 32 47 IL-12 IL-12 NNP cord-347706-r0rs3ls1 32 48 , , , cord-347706-r0rs3ls1 32 49 p70 p70 CD cord-347706-r0rs3ls1 32 50 , , , cord-347706-r0rs3ls1 32 51 IL-4 IL-4 NNP cord-347706-r0rs3ls1 32 52 , , , cord-347706-r0rs3ls1 32 53 IL-10 IL-10 NNP cord-347706-r0rs3ls1 32 54 , , , cord-347706-r0rs3ls1 32 55 and and CC cord-347706-r0rs3ls1 32 56 TNF TNF NNP cord-347706-r0rs3ls1 32 57 - - HYPH cord-347706-r0rs3ls1 32 58 α α NNP cord-347706-r0rs3ls1 32 59 ) ) -RRB- cord-347706-r0rs3ls1 32 60 and and CC cord-347706-r0rs3ls1 32 61 without without IN cord-347706-r0rs3ls1 32 62 evoking evoke VBG cord-347706-r0rs3ls1 32 63 marked marked JJ cord-347706-r0rs3ls1 32 64 leukocyte leukocyte NN cord-347706-r0rs3ls1 32 65 infiltration infiltration NN cord-347706-r0rs3ls1 32 66 of of IN cord-347706-r0rs3ls1 32 67 the the DT cord-347706-r0rs3ls1 32 68 lung lung NN cord-347706-r0rs3ls1 32 69 . . . cord-347706-r0rs3ls1 33 1 Taken take VBN cord-347706-r0rs3ls1 33 2 together together RB cord-347706-r0rs3ls1 33 3 with with IN cord-347706-r0rs3ls1 33 4 the the DT cord-347706-r0rs3ls1 33 5 observation observation NN cord-347706-r0rs3ls1 33 6 that that IN cord-347706-r0rs3ls1 33 7 beige beige JJ cord-347706-r0rs3ls1 33 8 , , , cord-347706-r0rs3ls1 33 9 CD1 CD1 NNP cord-347706-r0rs3ls1 33 10 -/and -/and NNP cord-347706-r0rs3ls1 34 1 RAG1 rag1 NN cord-347706-r0rs3ls1 34 2 -/mice -/mice . cord-347706-r0rs3ls1 35 1 clear clear NNP cord-347706-r0rs3ls1 35 2 SARS SARS NNP cord-347706-r0rs3ls1 35 3 - - HYPH cord-347706-r0rs3ls1 35 4 CoV CoV NNP cord-347706-r0rs3ls1 35 5 normally normally RB cord-347706-r0rs3ls1 35 6 , , , cord-347706-r0rs3ls1 35 7 proinflammatory proinflammatory JJ cord-347706-r0rs3ls1 35 8 chemokines chemokine NNS cord-347706-r0rs3ls1 35 9 may may MD cord-347706-r0rs3ls1 35 10 coordinate coordinate VB cord-347706-r0rs3ls1 35 11 a a DT cord-347706-r0rs3ls1 35 12 rapid rapid JJ cord-347706-r0rs3ls1 35 13 and and CC cord-347706-r0rs3ls1 35 14 highly highly RB cord-347706-r0rs3ls1 35 15 effective effective JJ cord-347706-r0rs3ls1 35 16 innate innate JJ cord-347706-r0rs3ls1 35 17 antiviral antiviral JJ cord-347706-r0rs3ls1 35 18 response response NN cord-347706-r0rs3ls1 35 19 in in IN cord-347706-r0rs3ls1 35 20 the the DT cord-347706-r0rs3ls1 35 21 lung lung NN cord-347706-r0rs3ls1 35 22 . . . cord-347706-r0rs3ls1 36 1 3 3 LS cord-347706-r0rs3ls1 37 1 In in IN cord-347706-r0rs3ls1 37 2 contrast contrast NN cord-347706-r0rs3ls1 37 3 to to IN cord-347706-r0rs3ls1 37 4 young young JJ cord-347706-r0rs3ls1 37 5 ( ( -LRB- cord-347706-r0rs3ls1 37 6 4 4 CD cord-347706-r0rs3ls1 37 7 to to IN cord-347706-r0rs3ls1 37 8 6-week 6-week JJ cord-347706-r0rs3ls1 37 9 - - HYPH cord-347706-r0rs3ls1 37 10 old old JJ cord-347706-r0rs3ls1 37 11 ) ) -RRB- cord-347706-r0rs3ls1 37 12 BALB BALB NNP cord-347706-r0rs3ls1 37 13 / / SYM cord-347706-r0rs3ls1 37 14 c c NN cord-347706-r0rs3ls1 37 15 mice mouse NNS cord-347706-r0rs3ls1 37 16 that that WDT cord-347706-r0rs3ls1 37 17 support support VBP cord-347706-r0rs3ls1 37 18 replication replication NN cord-347706-r0rs3ls1 37 19 of of IN cord-347706-r0rs3ls1 37 20 SARS SARS NNP cord-347706-r0rs3ls1 37 21 - - HYPH cord-347706-r0rs3ls1 37 22 CoV CoV NNP cord-347706-r0rs3ls1 37 23 in in IN cord-347706-r0rs3ls1 37 24 the the DT cord-347706-r0rs3ls1 37 25 absence absence NN cord-347706-r0rs3ls1 37 26 of of IN cord-347706-r0rs3ls1 37 27 clinical clinical JJ cord-347706-r0rs3ls1 37 28 illness illness NN cord-347706-r0rs3ls1 37 29 and and CC cord-347706-r0rs3ls1 37 30 pneumonitis pneumonitis NN cord-347706-r0rs3ls1 37 31 , , , cord-347706-r0rs3ls1 37 32 old old JJ cord-347706-r0rs3ls1 37 33 ( ( -LRB- cord-347706-r0rs3ls1 37 34 13 13 CD cord-347706-r0rs3ls1 37 35 to to TO cord-347706-r0rs3ls1 37 36 14-month 14-month JJ cord-347706-r0rs3ls1 37 37 - - HYPH cord-347706-r0rs3ls1 37 38 old old JJ cord-347706-r0rs3ls1 37 39 ) ) -RRB- cord-347706-r0rs3ls1 38 1 BALB BALB NNP cord-347706-r0rs3ls1 38 2 / / SYM cord-347706-r0rs3ls1 38 3 c c NN cord-347706-r0rs3ls1 38 4 mice mouse NNS cord-347706-r0rs3ls1 38 5 demonstrate demonstrate VBP cord-347706-r0rs3ls1 38 6 illness illness NN cord-347706-r0rs3ls1 38 7 ( ( -LRB- cord-347706-r0rs3ls1 38 8 weight weight NN cord-347706-r0rs3ls1 38 9 loss loss NN cord-347706-r0rs3ls1 38 10 , , , cord-347706-r0rs3ls1 38 11 hunching hunching NN cord-347706-r0rs3ls1 38 12 , , , cord-347706-r0rs3ls1 38 13 dehydration dehydration NN cord-347706-r0rs3ls1 38 14 , , , cord-347706-r0rs3ls1 38 15 and and CC cord-347706-r0rs3ls1 38 16 ruffled ruffled JJ cord-347706-r0rs3ls1 38 17 fur fur NN cord-347706-r0rs3ls1 38 18 from from IN cord-347706-r0rs3ls1 38 19 days day NNS cord-347706-r0rs3ls1 38 20 3 3 CD cord-347706-r0rs3ls1 38 21 to to IN cord-347706-r0rs3ls1 38 22 6 6 CD cord-347706-r0rs3ls1 38 23 postinfection postinfection NN cord-347706-r0rs3ls1 38 24 ) ) -RRB- cord-347706-r0rs3ls1 38 25 and and CC cord-347706-r0rs3ls1 38 26 interstitial interstitial JJ cord-347706-r0rs3ls1 38 27 pneumonitis pneumonitis NN cord-347706-r0rs3ls1 38 28 . . . cord-347706-r0rs3ls1 39 1 5 5 LS cord-347706-r0rs3ls1 40 1 Perivascular Perivascular NNP cord-347706-r0rs3ls1 40 2 lymphocytic lymphocytic NN cord-347706-r0rs3ls1 40 3 infiltrates infiltrate VBZ cord-347706-r0rs3ls1 40 4 noted note VBN cord-347706-r0rs3ls1 40 5 at at IN cord-347706-r0rs3ls1 40 6 day day NN cord-347706-r0rs3ls1 40 7 3 3 CD cord-347706-r0rs3ls1 40 8 were be VBD cord-347706-r0rs3ls1 40 9 more more RBR cord-347706-r0rs3ls1 40 10 prominent prominent JJ cord-347706-r0rs3ls1 40 11 by by IN cord-347706-r0rs3ls1 40 12 day day NN cord-347706-r0rs3ls1 40 13 5 5 CD cord-347706-r0rs3ls1 40 14 and and CC cord-347706-r0rs3ls1 40 15 evidence evidence NN cord-347706-r0rs3ls1 40 16 of of IN cord-347706-r0rs3ls1 40 17 alveolar alveolar JJ cord-347706-r0rs3ls1 40 18 damage damage NN cord-347706-r0rs3ls1 40 19 was be VBD cord-347706-r0rs3ls1 40 20 seen see VBN cord-347706-r0rs3ls1 40 21 , , , cord-347706-r0rs3ls1 40 22 with with IN cord-347706-r0rs3ls1 40 23 multifocal multifocal JJ cord-347706-r0rs3ls1 40 24 interstitial interstitial JJ cord-347706-r0rs3ls1 40 25 lymphohistiocytic lymphohistiocytic NN cord-347706-r0rs3ls1 40 26 infiltrates infiltrate VBZ cord-347706-r0rs3ls1 40 27 , , , cord-347706-r0rs3ls1 40 28 proteinaceous proteinaceous JJ cord-347706-r0rs3ls1 40 29 deposits deposit NNS cord-347706-r0rs3ls1 40 30 around around IN cord-347706-r0rs3ls1 40 31 alveolar alveolar JJ cord-347706-r0rs3ls1 40 32 walls wall NNS cord-347706-r0rs3ls1 40 33 and and CC cord-347706-r0rs3ls1 40 34 intraalveolar intraalveolar NN cord-347706-r0rs3ls1 40 35 edema edema NN cord-347706-r0rs3ls1 40 36 . . . cord-347706-r0rs3ls1 41 1 At at IN cord-347706-r0rs3ls1 41 2 day day NN cord-347706-r0rs3ls1 41 3 9 9 CD cord-347706-r0rs3ls1 41 4 , , , cord-347706-r0rs3ls1 41 5 the the DT cord-347706-r0rs3ls1 41 6 perivascular perivascular NN cord-347706-r0rs3ls1 41 7 infiltrates infiltrate VBZ cord-347706-r0rs3ls1 41 8 persisted persist VBD cord-347706-r0rs3ls1 41 9 and and CC cord-347706-r0rs3ls1 41 10 the the DT cord-347706-r0rs3ls1 41 11 changes change NNS cord-347706-r0rs3ls1 41 12 associated associate VBN cord-347706-r0rs3ls1 41 13 with with IN cord-347706-r0rs3ls1 41 14 alveolar alveolar JJ cord-347706-r0rs3ls1 41 15 damage damage NN cord-347706-r0rs3ls1 41 16 were be VBD cord-347706-r0rs3ls1 41 17 accompanied accompany VBN cord-347706-r0rs3ls1 41 18 by by IN cord-347706-r0rs3ls1 41 19 proliferation proliferation NN cord-347706-r0rs3ls1 41 20 of of IN cord-347706-r0rs3ls1 41 21 fibroblasts fibroblast NNS cord-347706-r0rs3ls1 41 22 in in IN cord-347706-r0rs3ls1 41 23 inflammatory inflammatory JJ cord-347706-r0rs3ls1 41 24 foci foci NN cord-347706-r0rs3ls1 41 25 . . . cord-347706-r0rs3ls1 42 1 A a DT cord-347706-r0rs3ls1 42 2 few few JJ cord-347706-r0rs3ls1 42 3 of of IN cord-347706-r0rs3ls1 42 4 these these DT cord-347706-r0rs3ls1 42 5 foci focus NNS cord-347706-r0rs3ls1 42 6 persisted persist VBD cord-347706-r0rs3ls1 42 7 through through IN cord-347706-r0rs3ls1 42 8 29 29 CD cord-347706-r0rs3ls1 42 9 days day NNS cord-347706-r0rs3ls1 42 10 post post NN cord-347706-r0rs3ls1 42 11 - - NN cord-347706-r0rs3ls1 42 12 infection infection NN cord-347706-r0rs3ls1 42 13 and and CC cord-347706-r0rs3ls1 42 14 may may MD cord-347706-r0rs3ls1 42 15 represent represent VB cord-347706-r0rs3ls1 42 16 the the DT cord-347706-r0rs3ls1 42 17 histologic histologic JJ cord-347706-r0rs3ls1 42 18 correlate correlate NN cord-347706-r0rs3ls1 42 19 of of IN cord-347706-r0rs3ls1 42 20 fibrosis fibrosis NN cord-347706-r0rs3ls1 42 21 and and CC cord-347706-r0rs3ls1 42 22 scarring scarring NN cord-347706-r0rs3ls1 42 23 seen see VBN cord-347706-r0rs3ls1 42 24 by by IN cord-347706-r0rs3ls1 42 25 high high JJ cord-347706-r0rs3ls1 42 26 - - HYPH cord-347706-r0rs3ls1 42 27 resolution resolution NN cord-347706-r0rs3ls1 42 28 computed compute VBN cord-347706-r0rs3ls1 42 29 tomography tomography NN cord-347706-r0rs3ls1 42 30 in in IN cord-347706-r0rs3ls1 42 31 patients patient NNS cord-347706-r0rs3ls1 42 32 who who WP cord-347706-r0rs3ls1 42 33 recovered recover VBD cord-347706-r0rs3ls1 42 34 from from IN cord-347706-r0rs3ls1 42 35 SARS SARS NNP cord-347706-r0rs3ls1 42 36 . . . cord-347706-r0rs3ls1 43 1 5 5 LS cord-347706-r0rs3ls1 43 2 Mice mouse NNS cord-347706-r0rs3ls1 43 3 with with IN cord-347706-r0rs3ls1 43 4 a a DT cord-347706-r0rs3ls1 43 5 targeted target VBN cord-347706-r0rs3ls1 43 6 disruption disruption NN cord-347706-r0rs3ls1 43 7 of of IN cord-347706-r0rs3ls1 43 8 the the DT cord-347706-r0rs3ls1 43 9 STAT stat NN cord-347706-r0rs3ls1 43 10 1 1 CD cord-347706-r0rs3ls1 43 11 signaling signal VBG cord-347706-r0rs3ls1 43 12 pathway pathway NN cord-347706-r0rs3ls1 43 13 develop develop VBP cord-347706-r0rs3ls1 43 14 severe severe JJ cord-347706-r0rs3ls1 43 15 SARS SARS NNP cord-347706-r0rs3ls1 43 16 - - : cord-347706-r0rs3ls1 43 17 When when WRB cord-347706-r0rs3ls1 43 18 6 6 CD cord-347706-r0rs3ls1 43 19 to to TO cord-347706-r0rs3ls1 43 20 8-week 8-week JJ cord-347706-r0rs3ls1 43 21 - - HYPH cord-347706-r0rs3ls1 43 22 old old JJ cord-347706-r0rs3ls1 43 23 lightly lightly RB cord-347706-r0rs3ls1 43 24 anesthetized anesthetize VBN cord-347706-r0rs3ls1 43 25 BALB BALB NNP cord-347706-r0rs3ls1 43 26 / / SYM cord-347706-r0rs3ls1 43 27 c c NN cord-347706-r0rs3ls1 43 28 mice mouse NNS cord-347706-r0rs3ls1 43 29 are be VBP cord-347706-r0rs3ls1 43 30 administered administer VBN cord-347706-r0rs3ls1 43 31 SARS- SARS- NNP cord-347706-r0rs3ls1 44 1 progresses progress VBZ cord-347706-r0rs3ls1 44 2 to to TO cord-347706-r0rs3ls1 44 3 diffuse diffuse VB cord-347706-r0rs3ls1 44 4 interstitial interstitial JJ cord-347706-r0rs3ls1 44 5 pneumonia pneumonia NN cord-347706-r0rs3ls1 44 6 with with IN cord-347706-r0rs3ls1 44 7 focal focal JJ cord-347706-r0rs3ls1 44 8 airspace airspace NN cord-347706-r0rs3ls1 44 9 consolidation consolidation NN cord-347706-r0rs3ls1 45 1 ( ( -LRB- cord-347706-r0rs3ls1 45 2 unpublished unpublished JJ cord-347706-r0rs3ls1 45 3 4 4 CD cord-347706-r0rs3ls1 45 4 infiltrates infiltrate NNS cord-347706-r0rs3ls1 45 5 . . . cord-347706-r0rs3ls1 46 1 At at IN cord-347706-r0rs3ls1 46 2 day day NN cord-347706-r0rs3ls1 46 3 27 27 CD cord-347706-r0rs3ls1 46 4 postinfection postinfection NN cord-347706-r0rs3ls1 46 5 , , , cord-347706-r0rs3ls1 46 6 nodules nodule NNS cord-347706-r0rs3ls1 46 7 of of IN cord-347706-r0rs3ls1 46 8 dense dense JJ cord-347706-r0rs3ls1 46 9 mononuclear mononuclear JJ cord-347706-r0rs3ls1 46 10 inflammation inflammation NN cord-347706-r0rs3ls1 46 11 containing contain VBG cord-347706-r0rs3ls1 46 12 SARS SARS NNP cord-347706-r0rs3ls1 46 13 - - HYPH cord-347706-r0rs3ls1 46 14 CoV CoV NNP cord-347706-r0rs3ls1 46 15 infected infect VBN cord-347706-r0rs3ls1 46 16 cells cell NNS cord-347706-r0rs3ls1 46 17 were be VBD cord-347706-r0rs3ls1 46 18 present present JJ cord-347706-r0rs3ls1 46 19 in in IN cord-347706-r0rs3ls1 46 20 the the DT cord-347706-r0rs3ls1 46 21 liver liver NN cord-347706-r0rs3ls1 46 22 . . . cord-347706-r0rs3ls1 47 1 4 4 LS cord-347706-r0rs3ls1 48 1 In in IN cord-347706-r0rs3ls1 48 2 STAT stat NN cord-347706-r0rs3ls1 48 3 1 1 CD cord-347706-r0rs3ls1 48 4 knockout knockout NN cord-347706-r0rs3ls1 48 5 mice mouse NNS cord-347706-r0rs3ls1 48 6 and and CC cord-347706-r0rs3ls1 48 7 old old JJ cord-347706-r0rs3ls1 48 8 BALB BALB NNP cord-347706-r0rs3ls1 48 9 / / SYM cord-347706-r0rs3ls1 48 10 c c NN cord-347706-r0rs3ls1 48 11 mice mouse NNS cord-347706-r0rs3ls1 48 12 , , , cord-347706-r0rs3ls1 48 13 SARS SARS NNP cord-347706-r0rs3ls1 48 14 - - HYPH cord-347706-r0rs3ls1 48 15 CoV CoV NNP cord-347706-r0rs3ls1 48 16 replicates replicate VBZ cord-347706-r0rs3ls1 48 17 to to IN cord-347706-r0rs3ls1 48 18 higher high JJR cord-347706-r0rs3ls1 48 19 titer titer NN cord-347706-r0rs3ls1 48 20 than than IN cord-347706-r0rs3ls1 48 21 in in IN cord-347706-r0rs3ls1 48 22 young young JJ cord-347706-r0rs3ls1 48 23 BALB BALB NNP cord-347706-r0rs3ls1 48 24 / / SYM cord-347706-r0rs3ls1 48 25 c c NN cord-347706-r0rs3ls1 48 26 mice mouse NNS cord-347706-r0rs3ls1 48 27 ; ; : cord-347706-r0rs3ls1 48 28 old old JJ cord-347706-r0rs3ls1 48 29 BALB BALB NNP cord-347706-r0rs3ls1 48 30 / / SYM cord-347706-r0rs3ls1 48 31 c c NN cord-347706-r0rs3ls1 48 32 mice mouse NNS cord-347706-r0rs3ls1 48 33 recover recover VBP cord-347706-r0rs3ls1 48 34 from from IN cord-347706-r0rs3ls1 48 35 the the DT cord-347706-r0rs3ls1 48 36 infection infection NN cord-347706-r0rs3ls1 48 37 . . . cord-347706-r0rs3ls1 49 1 5 5 LS cord-347706-r0rs3ls1 50 1 BALB BALB NNP cord-347706-r0rs3ls1 50 2 / / SYM cord-347706-r0rs3ls1 50 3 c c NN cord-347706-r0rs3ls1 50 4 and and CC cord-347706-r0rs3ls1 50 5 B6 b6 NN cord-347706-r0rs3ls1 50 6 mice mouse NNS cord-347706-r0rs3ls1 50 7 in in IN cord-347706-r0rs3ls1 50 8 the the DT cord-347706-r0rs3ls1 50 9 absence absence NN cord-347706-r0rs3ls1 50 10 of of IN cord-347706-r0rs3ls1 50 11 clinical clinical JJ cord-347706-r0rs3ls1 50 12 illness illness NN cord-347706-r0rs3ls1 50 13 and and CC cord-347706-r0rs3ls1 50 14 histopathologic histopathologic JJ cord-347706-r0rs3ls1 50 15 evidence evidence NN cord-347706-r0rs3ls1 50 16 of of IN cord-347706-r0rs3ls1 50 17 mild mild JJ cord-347706-r0rs3ls1 50 18 inflammation inflammation NN cord-347706-r0rs3ls1 50 19 while while IN cord-347706-r0rs3ls1 50 20 129SvEv 129svev CD cord-347706-r0rs3ls1 50 21 mice mouse NNS cord-347706-r0rs3ls1 50 22 show show VBP cord-347706-r0rs3ls1 50 23 some some DT cord-347706-r0rs3ls1 50 24 pneumonitis pneumonitis NN cord-347706-r0rs3ls1 50 25 . . . cord-347706-r0rs3ls1 51 1 Mice mouse NNS cord-347706-r0rs3ls1 51 2 that that WDT cord-347706-r0rs3ls1 51 3 recover recover VBP cord-347706-r0rs3ls1 51 4 from from IN cord-347706-r0rs3ls1 51 5 infection infection NN cord-347706-r0rs3ls1 51 6 develop develop VBP cord-347706-r0rs3ls1 51 7 a a DT cord-347706-r0rs3ls1 51 8 neutralizing neutralize VBG cord-347706-r0rs3ls1 51 9 antibody antibody NN cord-347706-r0rs3ls1 51 10 response response NN cord-347706-r0rs3ls1 51 11 and and CC cord-347706-r0rs3ls1 51 12 are be VBP cord-347706-r0rs3ls1 51 13 protected protect VBN cord-347706-r0rs3ls1 51 14 from from IN cord-347706-r0rs3ls1 51 15 subsequent subsequent JJ cord-347706-r0rs3ls1 51 16 challenge challenge NN cord-347706-r0rs3ls1 51 17 ; ; : cord-347706-r0rs3ls1 51 18 antibody antibody NN cord-347706-r0rs3ls1 51 19 alone alone RB cord-347706-r0rs3ls1 51 20 is be VBZ cord-347706-r0rs3ls1 51 21 sufficient sufficient JJ cord-347706-r0rs3ls1 51 22 to to TO cord-347706-r0rs3ls1 51 23 protect protect VB cord-347706-r0rs3ls1 51 24 mice mouse NNS cord-347706-r0rs3ls1 51 25 from from IN cord-347706-r0rs3ls1 51 26 replication replication NN cord-347706-r0rs3ls1 51 27 of of IN cord-347706-r0rs3ls1 51 28 SARS SARS NNP cord-347706-r0rs3ls1 51 29 - - HYPH cord-347706-r0rs3ls1 51 30 CoV CoV NNP cord-347706-r0rs3ls1 51 31 in in IN cord-347706-r0rs3ls1 51 32 the the DT cord-347706-r0rs3ls1 51 33 lower low JJR cord-347706-r0rs3ls1 51 34 respiratory respiratory JJ cord-347706-r0rs3ls1 51 35 tract tract NN cord-347706-r0rs3ls1 51 36 and and CC cord-347706-r0rs3ls1 51 37 NK NK NNP cord-347706-r0rs3ls1 51 38 , , , cord-347706-r0rs3ls1 51 39 NK NK NNP cord-347706-r0rs3ls1 51 40 - - HYPH cord-347706-r0rs3ls1 51 41 T T NNP cord-347706-r0rs3ls1 51 42 , , , cord-347706-r0rs3ls1 51 43 T T NNP cord-347706-r0rs3ls1 51 44 , , , cord-347706-r0rs3ls1 51 45 and and CC cord-347706-r0rs3ls1 51 46 B b NN cord-347706-r0rs3ls1 51 47 cells cell NNS cord-347706-r0rs3ls1 51 48 are be VBP cord-347706-r0rs3ls1 51 49 not not RB cord-347706-r0rs3ls1 51 50 required require VBN cord-347706-r0rs3ls1 51 51 for for IN cord-347706-r0rs3ls1 51 52 viral viral JJ cord-347706-r0rs3ls1 51 53 clearance clearance NN cord-347706-r0rs3ls1 51 54 . . . cord-347706-r0rs3ls1 52 1 3 3 LS cord-347706-r0rs3ls1 53 1 The the DT cord-347706-r0rs3ls1 53 2 efficacy efficacy NN cord-347706-r0rs3ls1 53 3 of of IN cord-347706-r0rs3ls1 53 4 several several JJ cord-347706-r0rs3ls1 53 5 vaccines vaccine NNS cord-347706-r0rs3ls1 53 6 and and CC cord-347706-r0rs3ls1 53 7 monoclonal monoclonal JJ cord-347706-r0rs3ls1 53 8 antibodies antibody NNS cord-347706-r0rs3ls1 53 9 has have VBZ cord-347706-r0rs3ls1 53 10 been be VBN cord-347706-r0rs3ls1 53 11 evaluated evaluate VBN cord-347706-r0rs3ls1 53 12 in in IN cord-347706-r0rs3ls1 53 13 BALB BALB NNP cord-347706-r0rs3ls1 53 14 / / SYM cord-347706-r0rs3ls1 53 15 c c NN cord-347706-r0rs3ls1 53 16 mice mouse NNS cord-347706-r0rs3ls1 53 17 . . . cord-347706-r0rs3ls1 54 1 [ [ -LRB- cord-347706-r0rs3ls1 54 2 6 6 CD cord-347706-r0rs3ls1 54 3 ] ] -RRB- cord-347706-r0rs3ls1 54 4 [ [ -LRB- cord-347706-r0rs3ls1 54 5 7 7 CD cord-347706-r0rs3ls1 54 6 ] ] -RRB- cord-347706-r0rs3ls1 54 7 [ [ -LRB- cord-347706-r0rs3ls1 54 8 8 8 CD cord-347706-r0rs3ls1 54 9 ] ] -RRB- cord-347706-r0rs3ls1 54 10 [ [ -LRB- cord-347706-r0rs3ls1 54 11 9 9 CD cord-347706-r0rs3ls1 54 12 ] ] -RRB- cord-347706-r0rs3ls1 54 13 [ [ -LRB- cord-347706-r0rs3ls1 54 14 10 10 CD cord-347706-r0rs3ls1 54 15 ] ] -RRB- cord-347706-r0rs3ls1 55 1 [ [ -LRB- cord-347706-r0rs3ls1 55 2 11 11 CD cord-347706-r0rs3ls1 55 3 ] ] -RRB- cord-347706-r0rs3ls1 55 4 [ [ -LRB- cord-347706-r0rs3ls1 55 5 12 12 CD cord-347706-r0rs3ls1 55 6 ] ] -RRB- cord-347706-r0rs3ls1 56 1 Morbidity morbidity NN cord-347706-r0rs3ls1 56 2 and and CC cord-347706-r0rs3ls1 56 3 mortality mortality NN cord-347706-r0rs3ls1 56 4 and and CC cord-347706-r0rs3ls1 56 5 pneumonitis pneumonitis NN cord-347706-r0rs3ls1 56 6 are be VBP cord-347706-r0rs3ls1 56 7 seen see VBN cord-347706-r0rs3ls1 56 8 in in IN cord-347706-r0rs3ls1 56 9 STAT-1 stat-1 NN cord-347706-r0rs3ls1 56 10 knockout knockout NN cord-347706-r0rs3ls1 56 11 mice mouse NNS cord-347706-r0rs3ls1 56 12 4 4 CD cord-347706-r0rs3ls1 56 13 and and CC cord-347706-r0rs3ls1 56 14 old old JJ cord-347706-r0rs3ls1 56 15 BALB BALB NNP cord-347706-r0rs3ls1 56 16 / / SYM cord-347706-r0rs3ls1 56 17 c c NN cord-347706-r0rs3ls1 56 18 mice mouse NNS cord-347706-r0rs3ls1 56 19 infected infect VBN cord-347706-r0rs3ls1 56 20 with with IN cord-347706-r0rs3ls1 56 21 SARS SARS NNP cord-347706-r0rs3ls1 56 22 - - HYPH cord-347706-r0rs3ls1 56 23 CoV. CoV. NNP cord-347706-r0rs3ls1 56 24 5 5 CD cord-347706-r0rs3ls1 57 1 The the DT cord-347706-r0rs3ls1 57 2 pathogenesis pathogenesis NN cord-347706-r0rs3ls1 57 3 of of IN cord-347706-r0rs3ls1 57 4 disease disease NN cord-347706-r0rs3ls1 57 5 in in IN cord-347706-r0rs3ls1 57 6 these these DT cord-347706-r0rs3ls1 57 7 models model NNS cord-347706-r0rs3ls1 57 8 is be VBZ cord-347706-r0rs3ls1 57 9 under under IN cord-347706-r0rs3ls1 57 10 investigation investigation NN cord-347706-r0rs3ls1 57 11 . . . cord-347706-r0rs3ls1 58 1 Infection infection NN cord-347706-r0rs3ls1 58 2 of of IN cord-347706-r0rs3ls1 58 3 BALB BALB NNP cord-347706-r0rs3ls1 58 4 / / SYM cord-347706-r0rs3ls1 58 5 c c NN cord-347706-r0rs3ls1 58 6 mice mouse NNS cord-347706-r0rs3ls1 58 7 and and CC cord-347706-r0rs3ls1 58 8 hamsters hamster NNS cord-347706-r0rs3ls1 58 9 used use VBD cord-347706-r0rs3ls1 58 10 the the DT cord-347706-r0rs3ls1 58 11 Urbani Urbani NNP cord-347706-r0rs3ls1 58 12 strain strain NN cord-347706-r0rs3ls1 58 13 of of IN cord-347706-r0rs3ls1 58 14 SARS SARS NNP cord-347706-r0rs3ls1 58 15 - - HYPH cord-347706-r0rs3ls1 58 16 CoV CoV NNP cord-347706-r0rs3ls1 58 17 while while IN cord-347706-r0rs3ls1 58 18 the the DT cord-347706-r0rs3ls1 58 19 SARS SARS NNP cord-347706-r0rs3ls1 58 20 - - HYPH cord-347706-r0rs3ls1 58 21 CoV CoV NNP cord-347706-r0rs3ls1 58 22 isolate isolate VBP cord-347706-r0rs3ls1 58 23 from from IN cord-347706-r0rs3ls1 58 24 patient patient JJ cord-347706-r0rs3ls1 58 25 5688 5688 CD cord-347706-r0rs3ls1 58 26 ( ( -LRB- cord-347706-r0rs3ls1 58 27 HKU-39849 HKU-39849 NNP cord-347706-r0rs3ls1 58 28 ) ) -RRB- cord-347706-r0rs3ls1 58 29 was be VBD cord-347706-r0rs3ls1 58 30 used use VBN cord-347706-r0rs3ls1 58 31 to to TO cord-347706-r0rs3ls1 58 32 infect infect VB cord-347706-r0rs3ls1 58 33 ferrets ferret NNS cord-347706-r0rs3ls1 58 34 ( ( -LRB- cord-347706-r0rs3ls1 58 35 Mustela Mustela NNP cord-347706-r0rs3ls1 58 36 furo furo NN cord-347706-r0rs3ls1 58 37 ) ) -RRB- cord-347706-r0rs3ls1 58 38 . . . cord-347706-r0rs3ls1 59 1 When when WRB cord-347706-r0rs3ls1 59 2 anesthetized anesthetize VBN cord-347706-r0rs3ls1 59 3 ferrets ferret NNS cord-347706-r0rs3ls1 59 4 were be VBD cord-347706-r0rs3ls1 59 5 infected infect VBN cord-347706-r0rs3ls1 59 6 with with IN cord-347706-r0rs3ls1 59 7 10 10 CD cord-347706-r0rs3ls1 59 8 6 6 CD cord-347706-r0rs3ls1 59 9 TCID TCID NNP cord-347706-r0rs3ls1 59 10 50 50 CD cord-347706-r0rs3ls1 59 11 by by IN cord-347706-r0rs3ls1 59 12 the the DT cord-347706-r0rs3ls1 59 13 intratracheal intratracheal NN cord-347706-r0rs3ls1 59 14 ( ( -LRB- cord-347706-r0rs3ls1 59 15 i.t i.t NNP cord-347706-r0rs3ls1 59 16 . . NNP cord-347706-r0rs3ls1 59 17 ) ) -RRB- cord-347706-r0rs3ls1 59 18 route route NN cord-347706-r0rs3ls1 59 19 , , , cord-347706-r0rs3ls1 59 20 three three CD cord-347706-r0rs3ls1 59 21 of of IN cord-347706-r0rs3ls1 59 22 six six CD cord-347706-r0rs3ls1 59 23 ferrets ferret NNS cord-347706-r0rs3ls1 59 24 were be VBD cord-347706-r0rs3ls1 59 25 lethargic lethargic JJ cord-347706-r0rs3ls1 59 26 from from IN cord-347706-r0rs3ls1 59 27 days day NNS cord-347706-r0rs3ls1 59 28 2 2 CD cord-347706-r0rs3ls1 59 29 to to IN cord-347706-r0rs3ls1 59 30 4 4 CD cord-347706-r0rs3ls1 59 31 postinfection postinfection NN cord-347706-r0rs3ls1 59 32 and and CC cord-347706-r0rs3ls1 59 33 one one CD cord-347706-r0rs3ls1 59 34 died die VBD cord-347706-r0rs3ls1 59 35 on on IN cord-347706-r0rs3ls1 59 36 day day NN cord-347706-r0rs3ls1 59 37 4 4 CD cord-347706-r0rs3ls1 59 38 . . . cord-347706-r0rs3ls1 60 1 14 14 CD cord-347706-r0rs3ls1 60 2 Virus virus NN cord-347706-r0rs3ls1 60 3 was be VBD cord-347706-r0rs3ls1 60 4 isolated isolate VBN cord-347706-r0rs3ls1 60 5 from from IN cord-347706-r0rs3ls1 60 6 pharyngeal pharyngeal JJ cord-347706-r0rs3ls1 60 7 swabs swab NNS cord-347706-r0rs3ls1 60 8 on on IN cord-347706-r0rs3ls1 60 9 days day NNS cord-347706-r0rs3ls1 60 10 2 2 CD cord-347706-r0rs3ls1 60 11 to to TO cord-347706-r0rs3ls1 60 12 8 8 CD cord-347706-r0rs3ls1 60 13 postinfection postinfection NN cord-347706-r0rs3ls1 60 14 and and CC cord-347706-r0rs3ls1 60 15 from from IN cord-347706-r0rs3ls1 60 16 trachea trachea NN cord-347706-r0rs3ls1 60 17 , , , cord-347706-r0rs3ls1 60 18 lungs lung NNS cord-347706-r0rs3ls1 60 19 and and CC cord-347706-r0rs3ls1 60 20 tracheobronchial tracheobronchial JJ cord-347706-r0rs3ls1 60 21 lymph lymph NN cord-347706-r0rs3ls1 60 22 nodes node NNS cord-347706-r0rs3ls1 60 23 at at IN cord-347706-r0rs3ls1 60 24 necropsy necropsy JJ cord-347706-r0rs3ls1 60 25 on on IN cord-347706-r0rs3ls1 60 26 day day NN cord-347706-r0rs3ls1 60 27 4 4 CD cord-347706-r0rs3ls1 60 28 . . . cord-347706-r0rs3ls1 61 1 When when WRB cord-347706-r0rs3ls1 61 2 administered administer VBN cord-347706-r0rs3ls1 61 3 i.t i.t NNP cord-347706-r0rs3ls1 61 4 . . NNP cord-347706-r0rs3ls1 61 5 at at IN cord-347706-r0rs3ls1 61 6 a a DT cord-347706-r0rs3ls1 61 7 dose dose NN cord-347706-r0rs3ls1 61 8 of of IN cord-347706-r0rs3ls1 61 9 10 10 CD cord-347706-r0rs3ls1 61 10 4 4 CD cord-347706-r0rs3ls1 61 11 TCID TCID NNP cord-347706-r0rs3ls1 61 12 50 50 CD cord-347706-r0rs3ls1 61 13 of of IN cord-347706-r0rs3ls1 61 14 SARS SARS NNP cord-347706-r0rs3ls1 61 15 - - HYPH cord-347706-r0rs3ls1 61 16 CoV CoV NNP cord-347706-r0rs3ls1 61 17 , , , cord-347706-r0rs3ls1 61 18 the the DT cord-347706-r0rs3ls1 61 19 virus virus NN cord-347706-r0rs3ls1 61 20 replicates replicate VBZ cord-347706-r0rs3ls1 61 21 efficiently efficiently RB cord-347706-r0rs3ls1 61 22 in in IN cord-347706-r0rs3ls1 61 23 the the DT cord-347706-r0rs3ls1 61 24 lungs lung NNS cord-347706-r0rs3ls1 61 25 to to IN cord-347706-r0rs3ls1 61 26 a a DT cord-347706-r0rs3ls1 61 27 titer titer NN cord-347706-r0rs3ls1 61 28 of of IN cord-347706-r0rs3ls1 61 29 10 10 CD cord-347706-r0rs3ls1 61 30 6 6 CD cord-347706-r0rs3ls1 61 31 TCID TCID NNP cord-347706-r0rs3ls1 61 32 50 50 CD cord-347706-r0rs3ls1 61 33 /ml /ml . cord-347706-r0rs3ls1 62 1 that that DT cord-347706-r0rs3ls1 62 2 peaks peak NNS cord-347706-r0rs3ls1 62 3 at at IN cord-347706-r0rs3ls1 62 4 4 4 CD cord-347706-r0rs3ls1 62 5 days day NNS cord-347706-r0rs3ls1 62 6 postinfection postinfection NN cord-347706-r0rs3ls1 62 7 . . . cord-347706-r0rs3ls1 63 1 15 15 CD cord-347706-r0rs3ls1 63 2 465 465 CD cord-347706-r0rs3ls1 63 3 observations observation NNS cord-347706-r0rs3ls1 63 4 ) ) -RRB- cord-347706-r0rs3ls1 63 5 . . . cord-347706-r0rs3ls1 64 1 V V NNP cord-347706-r0rs3ls1 64 2 iral iral NNP cord-347706-r0rs3ls1 64 3 antigen antigen NNP cord-347706-r0rs3ls1 64 4 was be VBD cord-347706-r0rs3ls1 64 5 present present JJ cord-347706-r0rs3ls1 64 6 within within IN cord-347706-r0rs3ls1 64 7 cells cell NNS cord-347706-r0rs3ls1 64 8 of of IN cord-347706-r0rs3ls1 64 9 the the DT cord-347706-r0rs3ls1 64 10 inflammatory inflammatory JJ cord-347706-r0rs3ls1 64 11 pulmonary pulmonary NN cord-347706-r0rs3ls1 64 12 Intranasally intranasally RB cord-347706-r0rs3ls1 64 13 administered administer VBN cord-347706-r0rs3ls1 64 14 SARS SARS NNP cord-347706-r0rs3ls1 64 15 - - HYPH cord-347706-r0rs3ls1 64 16 CoV CoV NNP cord-347706-r0rs3ls1 64 17 replicates replicate VBZ cord-347706-r0rs3ls1 64 18 efficiently efficiently RB cord-347706-r0rs3ls1 64 19 in in IN cord-347706-r0rs3ls1 64 20 the the DT cord-347706-r0rs3ls1 64 21 respiratory respiratory JJ cord-347706-r0rs3ls1 64 22 tract tract NN cord-347706-r0rs3ls1 64 23 of of IN cord-347706-r0rs3ls1 64 24 golden golden JJ cord-347706-r0rs3ls1 64 25 Syrian syrian JJ cord-347706-r0rs3ls1 64 26 hamsters hamster NNS cord-347706-r0rs3ls1 64 27 with with IN cord-347706-r0rs3ls1 64 28 a a DT cord-347706-r0rs3ls1 64 29 peak peak NN cord-347706-r0rs3ls1 64 30 of of IN cord-347706-r0rs3ls1 64 31 viral viral JJ cord-347706-r0rs3ls1 64 32 replication replication NN cord-347706-r0rs3ls1 64 33 in in IN cord-347706-r0rs3ls1 64 34 the the DT cord-347706-r0rs3ls1 64 35 lungs lung NNS cord-347706-r0rs3ls1 64 36 on on IN cord-347706-r0rs3ls1 64 37 days day NNS cord-347706-r0rs3ls1 64 38 2 2 CD cord-347706-r0rs3ls1 64 39 or or CC cord-347706-r0rs3ls1 64 40 3 3 CD cord-347706-r0rs3ls1 65 1 ( ( -LRB- cord-347706-r0rs3ls1 65 2 mean mean VB cord-347706-r0rs3ls1 65 3 titer titer NN cord-347706-r0rs3ls1 65 4 approximately approximately RB cord-347706-r0rs3ls1 65 5 10 10 CD cord-347706-r0rs3ls1 65 6 7 7 CD cord-347706-r0rs3ls1 65 7 TCID TCID NNP cord-347706-r0rs3ls1 65 8 50 50 CD cord-347706-r0rs3ls1 65 9 per per IN cord-347706-r0rs3ls1 65 10 gram gram NN cord-347706-r0rs3ls1 65 11 of of IN cord-347706-r0rs3ls1 65 12 lung lung NN cord-347706-r0rs3ls1 65 13 tissue tissue NN cord-347706-r0rs3ls1 65 14 following follow VBG cord-347706-r0rs3ls1 65 15 administration administration NN cord-347706-r0rs3ls1 65 16 of of IN cord-347706-r0rs3ls1 65 17 10 10 CD cord-347706-r0rs3ls1 65 18 3 3 CD cord-347706-r0rs3ls1 65 19 TCID TCID NNP cord-347706-r0rs3ls1 65 20 50 50 CD cord-347706-r0rs3ls1 65 21 i.n i.n NN cord-347706-r0rs3ls1 65 22 . . NNP cord-347706-r0rs3ls1 65 23 ) ) -RRB- cord-347706-r0rs3ls1 65 24 and and CC cord-347706-r0rs3ls1 65 25 clearance clearance NN cord-347706-r0rs3ls1 65 26 from from IN cord-347706-r0rs3ls1 65 27 the the DT cord-347706-r0rs3ls1 65 28 lungs lung NNS cord-347706-r0rs3ls1 65 29 by by IN cord-347706-r0rs3ls1 65 30 day day NN cord-347706-r0rs3ls1 65 31 10 10 CD cord-347706-r0rs3ls1 65 32 . . . cord-347706-r0rs3ls1 66 1 This this DT cord-347706-r0rs3ls1 66 2 is be VBZ cord-347706-r0rs3ls1 66 3 accompanied accompany VBN cord-347706-r0rs3ls1 66 4 by by IN cord-347706-r0rs3ls1 66 5 histopathologic histopathologic JJ cord-347706-r0rs3ls1 66 6 evidence evidence NN cord-347706-r0rs3ls1 66 7 of of IN cord-347706-r0rs3ls1 66 8 pneumonitis pneumonitis NN cord-347706-r0rs3ls1 66 9 . . . cord-347706-r0rs3ls1 67 1 Mild mild JJ cord-347706-r0rs3ls1 67 2 mononuclear mononuclear JJ cord-347706-r0rs3ls1 67 3 inflammatory inflammatory JJ cord-347706-r0rs3ls1 67 4 cell cell NN cord-347706-r0rs3ls1 67 5 infiltrates infiltrate NNS cord-347706-r0rs3ls1 67 6 are be VBP cord-347706-r0rs3ls1 67 7 noted note VBN cord-347706-r0rs3ls1 67 8 in in IN cord-347706-r0rs3ls1 67 9 the the DT cord-347706-r0rs3ls1 67 10 submucosa submucosa NNP cord-347706-r0rs3ls1 67 11 of of IN cord-347706-r0rs3ls1 67 12 the the DT cord-347706-r0rs3ls1 67 13 nasal nasal NN cord-347706-r0rs3ls1 67 14 epithelium epithelium NN cord-347706-r0rs3ls1 67 15 and and CC cord-347706-r0rs3ls1 67 16 bronchioles bronchiole NNS cord-347706-r0rs3ls1 67 17 at at IN cord-347706-r0rs3ls1 67 18 day day NN cord-347706-r0rs3ls1 67 19 3 3 CD cord-347706-r0rs3ls1 67 20 postinfection postinfection NN cord-347706-r0rs3ls1 67 21 . . . cord-347706-r0rs3ls1 68 1 As as IN cord-347706-r0rs3ls1 68 2 inflammation inflammation NN cord-347706-r0rs3ls1 68 3 in in IN cord-347706-r0rs3ls1 68 4 the the DT cord-347706-r0rs3ls1 68 5 nasal nasal NN cord-347706-r0rs3ls1 68 6 tissues tissue NNS cord-347706-r0rs3ls1 68 7 resolves resolve VBZ cord-347706-r0rs3ls1 68 8 , , , cord-347706-r0rs3ls1 68 9 inflammatory inflammatory JJ cord-347706-r0rs3ls1 68 10 reaction reaction NN cord-347706-r0rs3ls1 68 11 in in IN cord-347706-r0rs3ls1 68 12 the the DT cord-347706-r0rs3ls1 68 13 lungs lung NNS cord-347706-r0rs3ls1 68 14 progresses progress VBZ cord-347706-r0rs3ls1 68 15 , , , cord-347706-r0rs3ls1 68 16 with with IN cord-347706-r0rs3ls1 68 17 confluent confluent JJ cord-347706-r0rs3ls1 68 18 areas area NNS cord-347706-r0rs3ls1 68 19 of of IN cord-347706-r0rs3ls1 68 20 consolidation consolidation NN cord-347706-r0rs3ls1 68 21 that that WDT cord-347706-r0rs3ls1 68 22 involve involve VBP cord-347706-r0rs3ls1 68 23 30 30 CD cord-347706-r0rs3ls1 68 24 - - SYM cord-347706-r0rs3ls1 68 25 40 40 CD cord-347706-r0rs3ls1 68 26 % % NN cord-347706-r0rs3ls1 68 27 of of IN cord-347706-r0rs3ls1 68 28 the the DT cord-347706-r0rs3ls1 68 29 surface surface NN cord-347706-r0rs3ls1 68 30 of of IN cord-347706-r0rs3ls1 68 31 the the DT cord-347706-r0rs3ls1 68 32 lung lung NN cord-347706-r0rs3ls1 68 33 by by IN cord-347706-r0rs3ls1 68 34 day day NN cord-347706-r0rs3ls1 68 35 7 7 CD cord-347706-r0rs3ls1 68 36 postinfection postinfection NN cord-347706-r0rs3ls1 68 37 with with IN cord-347706-r0rs3ls1 68 38 resolution resolution NN cord-347706-r0rs3ls1 68 39 by by IN cord-347706-r0rs3ls1 68 40 day day NN cord-347706-r0rs3ls1 68 41 14 14 CD cord-347706-r0rs3ls1 68 42 . . . cord-347706-r0rs3ls1 69 1 The the DT cord-347706-r0rs3ls1 69 2 lung lung NN cord-347706-r0rs3ls1 69 3 pathology pathology NN cord-347706-r0rs3ls1 69 4 is be VBZ cord-347706-r0rs3ls1 69 5 not not RB cord-347706-r0rs3ls1 69 6 associated associate VBN cord-347706-r0rs3ls1 69 7 with with IN cord-347706-r0rs3ls1 69 8 overt overt JJ cord-347706-r0rs3ls1 69 9 clinical clinical JJ cord-347706-r0rs3ls1 69 10 illness illness NN cord-347706-r0rs3ls1 69 11 . . . cord-347706-r0rs3ls1 70 1 In in IN cord-347706-r0rs3ls1 70 2 contrast contrast NN cord-347706-r0rs3ls1 70 3 to to IN cord-347706-r0rs3ls1 70 4 mice mouse NNS cord-347706-r0rs3ls1 70 5 in in IN cord-347706-r0rs3ls1 70 6 which which WDT cord-347706-r0rs3ls1 70 7 replication replication NN cord-347706-r0rs3ls1 70 8 of of IN cord-347706-r0rs3ls1 70 9 intranasally intranasally RB cord-347706-r0rs3ls1 70 10 administered administer VBN cord-347706-r0rs3ls1 70 11 SARS SARS NNP cord-347706-r0rs3ls1 70 12 - - HYPH cord-347706-r0rs3ls1 70 13 CoV CoV NNP cord-347706-r0rs3ls1 70 14 is be VBZ cord-347706-r0rs3ls1 70 15 restricted restrict VBN cord-347706-r0rs3ls1 70 16 to to IN cord-347706-r0rs3ls1 70 17 the the DT cord-347706-r0rs3ls1 70 18 respiratory respiratory JJ cord-347706-r0rs3ls1 70 19 tract tract NN cord-347706-r0rs3ls1 70 20 , , , cord-347706-r0rs3ls1 70 21 transient transient JJ cord-347706-r0rs3ls1 70 22 from from IN cord-347706-r0rs3ls1 70 23 infection infection NN cord-347706-r0rs3ls1 70 24 develop develop VBP cord-347706-r0rs3ls1 70 25 a a DT cord-347706-r0rs3ls1 70 26 robust robust JJ cord-347706-r0rs3ls1 70 27 neutralizing neutralize VBG cord-347706-r0rs3ls1 70 28 antibody antibody NN cord-347706-r0rs3ls1 70 29 response response NN cord-347706-r0rs3ls1 70 30 and and CC cord-347706-r0rs3ls1 70 31 are be VBP cord-347706-r0rs3ls1 70 32 protected protect VBN cord-347706-r0rs3ls1 70 33 from from IN cord-347706-r0rs3ls1 70 34 subsequent subsequent JJ cord-347706-r0rs3ls1 70 35 infection infection NN cord-347706-r0rs3ls1 70 36 with with IN cord-347706-r0rs3ls1 70 37 SARS SARS NNP cord-347706-r0rs3ls1 70 38 - - HYPH cord-347706-r0rs3ls1 70 39 CoV. CoV. NNP cord-347706-r0rs3ls1 71 1 There there EX cord-347706-r0rs3ls1 71 2 is be VBZ cord-347706-r0rs3ls1 71 3 no no DT cord-347706-r0rs3ls1 71 4 clinical clinical JJ cord-347706-r0rs3ls1 71 5 , , , cord-347706-r0rs3ls1 71 6 virologic virologic JJ cord-347706-r0rs3ls1 71 7 or or CC cord-347706-r0rs3ls1 71 8 histopathologic histopathologic JJ cord-347706-r0rs3ls1 71 9 evidence evidence NN cord-347706-r0rs3ls1 71 10 of of IN cord-347706-r0rs3ls1 71 11 enhanced enhanced JJ cord-347706-r0rs3ls1 71 12 disease disease NN cord-347706-r0rs3ls1 71 13 upon upon IN cord-347706-r0rs3ls1 71 14 reinfection reinfection NN cord-347706-r0rs3ls1 71 15 even even RB cord-347706-r0rs3ls1 71 16 in in IN cord-347706-r0rs3ls1 71 17 the the DT cord-347706-r0rs3ls1 71 18 presence presence NN cord-347706-r0rs3ls1 71 19 of of IN cord-347706-r0rs3ls1 71 20 sub sub NN cord-347706-r0rs3ls1 71 21 - - JJ cord-347706-r0rs3ls1 71 22 neutralizing neutralize VBG cord-347706-r0rs3ls1 71 23 levels level NNS cord-347706-r0rs3ls1 71 24 of of IN cord-347706-r0rs3ls1 71 25 monoclonal monoclonal JJ cord-347706-r0rs3ls1 71 26 antibodies antibody NNS cord-347706-r0rs3ls1 71 27 to to IN cord-347706-r0rs3ls1 71 28 the the DT cord-347706-r0rs3ls1 71 29 SARS SARS NNP cord-347706-r0rs3ls1 71 30 - - HYPH cord-347706-r0rs3ls1 71 31 CoV CoV NNP cord-347706-r0rs3ls1 71 32 spike spike NN cord-347706-r0rs3ls1 71 33 glycoprotein glycoprotein NN cord-347706-r0rs3ls1 71 34 . . . cord-347706-r0rs3ls1 72 1 13 13 CD cord-347706-r0rs3ls1 72 2 , , , cord-347706-r0rs3ls1 72 3 13b 13b NNP cord-347706-r0rs3ls1 72 4 CoV CoV NNP cord-347706-r0rs3ls1 72 5 disease disease NN cord-347706-r0rs3ls1 72 6 , , , cord-347706-r0rs3ls1 72 7 with with IN cord-347706-r0rs3ls1 72 8 weight weight NN cord-347706-r0rs3ls1 72 9 loss loss NN cord-347706-r0rs3ls1 72 10 and and CC cord-347706-r0rs3ls1 72 11 pneumonitis pneumonitis NN cord-347706-r0rs3ls1 72 12 that that WDT cord-347706-r0rs3ls1 72 13 begins begin VBZ cord-347706-r0rs3ls1 72 14 with with IN cord-347706-r0rs3ls1 72 15 acute acute JJ cord-347706-r0rs3ls1 72 16 bronchiolitis bronchiolitis NN cord-347706-r0rs3ls1 72 17 and and CC cord-347706-r0rs3ls1 73 1 In in IN cord-347706-r0rs3ls1 73 2 summary summary NN cord-347706-r0rs3ls1 73 3 , , , cord-347706-r0rs3ls1 73 4 SARS SARS NNP cord-347706-r0rs3ls1 73 5 - - HYPH cord-347706-r0rs3ls1 73 6 CoV CoV NNP cord-347706-r0rs3ls1 73 7 replicates replicate VBZ cord-347706-r0rs3ls1 73 8 efficiently efficiently RB cord-347706-r0rs3ls1 73 9 in in IN cord-347706-r0rs3ls1 73 10 the the DT cord-347706-r0rs3ls1 73 11 respiratory respiratory JJ cord-347706-r0rs3ls1 73 12 tract tract NN cord-347706-r0rs3ls1 73 13 of of IN cord-347706-r0rs3ls1 73 14 young young JJ cord-347706-r0rs3ls1 73 15 viremia viremia NN cord-347706-r0rs3ls1 73 16 occurs occur VBZ cord-347706-r0rs3ls1 73 17 1 1 CD cord-347706-r0rs3ls1 73 18 to to TO cord-347706-r0rs3ls1 73 19 2 2 CD cord-347706-r0rs3ls1 73 20 days day NNS cord-347706-r0rs3ls1 73 21 following follow VBG cord-347706-r0rs3ls1 73 22 infection infection NN cord-347706-r0rs3ls1 73 23 and and CC cord-347706-r0rs3ls1 73 24 virus virus NN cord-347706-r0rs3ls1 73 25 is be VBZ cord-347706-r0rs3ls1 73 26 detected detect VBN cord-347706-r0rs3ls1 73 27 in in IN cord-347706-r0rs3ls1 73 28 the the DT cord-347706-r0rs3ls1 73 29 liver liver NN cord-347706-r0rs3ls1 73 30 and and CC cord-347706-r0rs3ls1 73 31 spleen spleen NNS cord-347706-r0rs3ls1 73 32 in in IN cord-347706-r0rs3ls1 73 33 hamsters hamster NNS cord-347706-r0rs3ls1 73 34 . . . cord-347706-r0rs3ls1 74 1 However however RB cord-347706-r0rs3ls1 74 2 , , , cord-347706-r0rs3ls1 74 3 inflammation inflammation NN cord-347706-r0rs3ls1 74 4 is be VBZ cord-347706-r0rs3ls1 74 5 not not RB cord-347706-r0rs3ls1 74 6 observed observe VBN cord-347706-r0rs3ls1 74 7 in in IN cord-347706-r0rs3ls1 74 8 these these DT cord-347706-r0rs3ls1 74 9 organs organ NNS cord-347706-r0rs3ls1 74 10 . . . cord-347706-r0rs3ls1 75 1 Hamsters hamster NNS cord-347706-r0rs3ls1 75 2 that that WDT cord-347706-r0rs3ls1 75 3 recover recover VBP cord-347706-r0rs3ls1 75 4 Multifocal multifocal JJ cord-347706-r0rs3ls1 75 5 pulmonary pulmonary JJ cord-347706-r0rs3ls1 75 6 lesions lesion NNS cord-347706-r0rs3ls1 75 7 affecting affect VBG cord-347706-r0rs3ls1 75 8 5 5 CD cord-347706-r0rs3ls1 75 9 - - SYM cord-347706-r0rs3ls1 75 10 10 10 CD cord-347706-r0rs3ls1 75 11 % % NN cord-347706-r0rs3ls1 75 12 of of IN cord-347706-r0rs3ls1 75 13 lung lung NN cord-347706-r0rs3ls1 75 14 surface surface NN cord-347706-r0rs3ls1 75 15 area area NN cord-347706-r0rs3ls1 75 16 include include VBP cord-347706-r0rs3ls1 75 17 mild mild JJ cord-347706-r0rs3ls1 75 18 alveolar alveolar JJ cord-347706-r0rs3ls1 75 19 damage damage NN cord-347706-r0rs3ls1 75 20 and and CC cord-347706-r0rs3ls1 75 21 peribronchial peribronchial JJ cord-347706-r0rs3ls1 75 22 and and CC cord-347706-r0rs3ls1 75 23 perivascular perivascular JJ cord-347706-r0rs3ls1 75 24 lymphocyte lymphocyte NN cord-347706-r0rs3ls1 75 25 infiltration infiltration NN cord-347706-r0rs3ls1 75 26 . . . cord-347706-r0rs3ls1 76 1 15 15 CD cord-347706-r0rs3ls1 76 2 , , , cord-347706-r0rs3ls1 76 3 16 16 CD cord-347706-r0rs3ls1 76 4 Ferrets ferret NNS cord-347706-r0rs3ls1 76 5 are be VBP cord-347706-r0rs3ls1 76 6 outbred outbred JJ cord-347706-r0rs3ls1 76 7 animals animal NNS cord-347706-r0rs3ls1 76 8 that that WDT cord-347706-r0rs3ls1 76 9 are be VBP cord-347706-r0rs3ls1 76 10 highly highly RB cord-347706-r0rs3ls1 76 11 susceptible susceptible JJ cord-347706-r0rs3ls1 76 12 to to IN cord-347706-r0rs3ls1 76 13 viruses virus NNS cord-347706-r0rs3ls1 76 14 that that WDT cord-347706-r0rs3ls1 76 15 they -PRON- PRP cord-347706-r0rs3ls1 76 16 can can MD cord-347706-r0rs3ls1 76 17 acquire acquire VB cord-347706-r0rs3ls1 76 18 from from IN cord-347706-r0rs3ls1 76 19 their -PRON- PRP$ cord-347706-r0rs3ls1 76 20 caretakers caretaker NNS cord-347706-r0rs3ls1 76 21 . . . cord-347706-r0rs3ls1 77 1 Ferrets ferret NNS cord-347706-r0rs3ls1 77 2 used use VBN cord-347706-r0rs3ls1 77 3 as as IN cord-347706-r0rs3ls1 77 4 models model NNS cord-347706-r0rs3ls1 77 5 for for IN cord-347706-r0rs3ls1 77 6 SARS SARS NNP cord-347706-r0rs3ls1 77 7 should should MD cord-347706-r0rs3ls1 77 8 be be VB cord-347706-r0rs3ls1 77 9 screened screen VBN cord-347706-r0rs3ls1 77 10 to to TO cord-347706-r0rs3ls1 77 11 ensure ensure VB cord-347706-r0rs3ls1 77 12 that that IN cord-347706-r0rs3ls1 77 13 other other JJ cord-347706-r0rs3ls1 77 14 intercurrent intercurrent NN cord-347706-r0rs3ls1 77 15 infections infection NNS cord-347706-r0rs3ls1 77 16 do do VBP cord-347706-r0rs3ls1 77 17 not not RB cord-347706-r0rs3ls1 77 18 modify modify VB cord-347706-r0rs3ls1 77 19 the the DT cord-347706-r0rs3ls1 77 20 disease disease NN cord-347706-r0rs3ls1 77 21 associated associate VBN cord-347706-r0rs3ls1 77 22 with with IN cord-347706-r0rs3ls1 77 23 SARS SARS NNP cord-347706-r0rs3ls1 77 24 - - HYPH cord-347706-r0rs3ls1 77 25 CoV CoV NNP cord-347706-r0rs3ls1 77 26 infection infection NN cord-347706-r0rs3ls1 77 27 . . . cord-347706-r0rs3ls1 78 1 In in IN cord-347706-r0rs3ls1 78 2 2003 2003 CD cord-347706-r0rs3ls1 78 3 , , , cord-347706-r0rs3ls1 78 4 SARS SARS NNP cord-347706-r0rs3ls1 78 5 - - HYPH cord-347706-r0rs3ls1 78 6 CoV CoV NNP cord-347706-r0rs3ls1 78 7 was be VBD cord-347706-r0rs3ls1 78 8 isolated isolate VBN cord-347706-r0rs3ls1 78 9 from from IN cord-347706-r0rs3ls1 78 10 captive captive JJ cord-347706-r0rs3ls1 78 11 civet civet NN cord-347706-r0rs3ls1 78 12 cats cat NNS cord-347706-r0rs3ls1 78 13 in in IN cord-347706-r0rs3ls1 78 14 wild wild JJ cord-347706-r0rs3ls1 78 15 animal animal NN cord-347706-r0rs3ls1 78 16 markets market NNS cord-347706-r0rs3ls1 78 17 in in IN cord-347706-r0rs3ls1 78 18 Guangdong Guangdong NNP cord-347706-r0rs3ls1 78 19 Province Province NNP cord-347706-r0rs3ls1 78 20 , , , cord-347706-r0rs3ls1 78 21 China China NNP cord-347706-r0rs3ls1 78 22 , , , cord-347706-r0rs3ls1 78 23 and and CC cord-347706-r0rs3ls1 78 24 several several JJ cord-347706-r0rs3ls1 78 25 civet civet NN cord-347706-r0rs3ls1 78 26 cats cat NNS cord-347706-r0rs3ls1 78 27 had have VBD cord-347706-r0rs3ls1 78 28 detectable detectable JJ cord-347706-r0rs3ls1 78 29 antibodies antibody NNS cord-347706-r0rs3ls1 78 30 to to IN cord-347706-r0rs3ls1 78 31 SARS SARS NNP cord-347706-r0rs3ls1 78 32 - - HYPH cord-347706-r0rs3ls1 78 33 CoV. CoV. NNP cord-347706-r0rs3ls1 79 1 In in IN cord-347706-r0rs3ls1 79 2 a a DT cord-347706-r0rs3ls1 79 3 recent recent JJ cord-347706-r0rs3ls1 79 4 report report NN cord-347706-r0rs3ls1 79 5 , , , cord-347706-r0rs3ls1 79 6 Wu Wu NNP cord-347706-r0rs3ls1 79 7 et et NNP cord-347706-r0rs3ls1 79 8 al al NNP cord-347706-r0rs3ls1 79 9 . . . cord-347706-r0rs3ls1 80 1 17 17 CD cord-347706-r0rs3ls1 80 2 infected infect VBN cord-347706-r0rs3ls1 80 3 farmed farm VBN cord-347706-r0rs3ls1 80 4 civet civet NN cord-347706-r0rs3ls1 80 5 cats cat NNS cord-347706-r0rs3ls1 80 6 with with IN cord-347706-r0rs3ls1 80 7 two two CD cord-347706-r0rs3ls1 80 8 strains strain NNS cord-347706-r0rs3ls1 80 9 of of IN cord-347706-r0rs3ls1 80 10 SARS SARS NNP cord-347706-r0rs3ls1 80 11 - - HYPH cord-347706-r0rs3ls1 80 12 CoV CoV NNP cord-347706-r0rs3ls1 80 13 : : : cord-347706-r0rs3ls1 80 14 five five CD cord-347706-r0rs3ls1 80 15 animals animal NNS cord-347706-r0rs3ls1 80 16 were be VBD cord-347706-r0rs3ls1 80 17 infected infect VBN cord-347706-r0rs3ls1 80 18 with with IN cord-347706-r0rs3ls1 80 19 the the DT cord-347706-r0rs3ls1 80 20 GZ01 gz01 JJ cord-347706-r0rs3ls1 80 21 virus virus NN cord-347706-r0rs3ls1 80 22 , , , cord-347706-r0rs3ls1 80 23 the the DT cord-347706-r0rs3ls1 80 24 prototype prototype NN cord-347706-r0rs3ls1 80 25 of of IN cord-347706-r0rs3ls1 80 26 the the DT cord-347706-r0rs3ls1 80 27 virus virus NN cord-347706-r0rs3ls1 80 28 isolated isolate VBN cord-347706-r0rs3ls1 80 29 from from IN cord-347706-r0rs3ls1 80 30 civet civet NN cord-347706-r0rs3ls1 80 31 cats cat NNS cord-347706-r0rs3ls1 80 32 , , , cord-347706-r0rs3ls1 80 33 and and CC cord-347706-r0rs3ls1 80 34 5 5 CD cord-347706-r0rs3ls1 80 35 animals animal NNS cord-347706-r0rs3ls1 80 36 were be VBD cord-347706-r0rs3ls1 80 37 infected infect VBN cord-347706-r0rs3ls1 80 38 with with IN cord-347706-r0rs3ls1 80 39 BJ01 BJ01 NNP cord-347706-r0rs3ls1 80 40 , , , cord-347706-r0rs3ls1 80 41 a a DT cord-347706-r0rs3ls1 80 42 SARS SARS NNP cord-347706-r0rs3ls1 80 43 - - HYPH cord-347706-r0rs3ls1 80 44 CoV cov NN cord-347706-r0rs3ls1 80 45 strain strain NN cord-347706-r0rs3ls1 80 46 that that WDT cord-347706-r0rs3ls1 80 47 is be VBZ cord-347706-r0rs3ls1 80 48 typical typical JJ cord-347706-r0rs3ls1 80 49 of of IN cord-347706-r0rs3ls1 80 50 viruses virus NNS cord-347706-r0rs3ls1 80 51 isolated isolate VBN cord-347706-r0rs3ls1 80 52 in in IN cord-347706-r0rs3ls1 80 53 Hong Hong NNP cord-347706-r0rs3ls1 80 54 Kong Kong NNP cord-347706-r0rs3ls1 80 55 during during IN cord-347706-r0rs3ls1 80 56 the the DT cord-347706-r0rs3ls1 80 57 SARS SARS NNP cord-347706-r0rs3ls1 80 58 outbreak outbreak NN cord-347706-r0rs3ls1 80 59 . . . cord-347706-r0rs3ls1 81 1 BJ01 BJ01 NNP cord-347706-r0rs3ls1 81 2 has have VBZ cord-347706-r0rs3ls1 81 3 a a DT cord-347706-r0rs3ls1 81 4 29nucleotide 29nucleotide CD cord-347706-r0rs3ls1 81 5 deletion deletion NN cord-347706-r0rs3ls1 81 6 in in IN cord-347706-r0rs3ls1 81 7 its -PRON- PRP$ cord-347706-r0rs3ls1 81 8 genome genome NN cord-347706-r0rs3ls1 81 9 compared compare VBN cord-347706-r0rs3ls1 81 10 with with IN cord-347706-r0rs3ls1 81 11 GZ01 GZ01 NNP cord-347706-r0rs3ls1 81 12 . . . cord-347706-r0rs3ls1 82 1 The the DT cord-347706-r0rs3ls1 82 2 civet civet NN cord-347706-r0rs3ls1 82 3 cats cat NNS cord-347706-r0rs3ls1 82 4 were be VBD cord-347706-r0rs3ls1 82 5 infected infect VBN cord-347706-r0rs3ls1 82 6 with with IN cord-347706-r0rs3ls1 82 7 a a DT cord-347706-r0rs3ls1 82 8 dose dose NN cord-347706-r0rs3ls1 82 9 of of IN cord-347706-r0rs3ls1 82 10 3 3 CD cord-347706-r0rs3ls1 82 11 x x SYM cord-347706-r0rs3ls1 82 12 10 10 CD cord-347706-r0rs3ls1 82 13 6 6 CD cord-347706-r0rs3ls1 82 14 TCID TCID NNP cord-347706-r0rs3ls1 82 15 50 50 CD cord-347706-r0rs3ls1 82 16 administered administer VBN cord-347706-r0rs3ls1 82 17 i.t i.t NNP cord-347706-r0rs3ls1 82 18 . . . cord-347706-r0rs3ls1 83 1 and and CC cord-347706-r0rs3ls1 83 2 i.n i.n NNP cord-347706-r0rs3ls1 83 3 . . . cord-347706-r0rs3ls1 84 1 In in IN cord-347706-r0rs3ls1 84 2 contrast contrast NN cord-347706-r0rs3ls1 84 3 with with IN cord-347706-r0rs3ls1 84 4 the the DT cord-347706-r0rs3ls1 84 5 observation observation NN cord-347706-r0rs3ls1 84 6 that that IN cord-347706-r0rs3ls1 84 7 SARS SARS NNP cord-347706-r0rs3ls1 84 8 - - HYPH cord-347706-r0rs3ls1 84 9 CoV CoV NNP cord-347706-r0rs3ls1 84 10 infected infect VBD cord-347706-r0rs3ls1 84 11 wild wild JJ cord-347706-r0rs3ls1 84 12 civets civet NNS cord-347706-r0rs3ls1 84 13 appeared appear VBD cord-347706-r0rs3ls1 84 14 healthy healthy JJ cord-347706-r0rs3ls1 84 15 , , , cord-347706-r0rs3ls1 84 16 lethargy lethargy NN cord-347706-r0rs3ls1 84 17 and and CC cord-347706-r0rs3ls1 84 18 a a DT cord-347706-r0rs3ls1 84 19 decrease decrease NN cord-347706-r0rs3ls1 84 20 in in IN cord-347706-r0rs3ls1 84 21 aggressiveness aggressiveness NN cord-347706-r0rs3ls1 84 22 was be VBD cord-347706-r0rs3ls1 84 23 noted note VBN cord-347706-r0rs3ls1 84 24 in in IN cord-347706-r0rs3ls1 84 25 the the DT cord-347706-r0rs3ls1 84 26 experimentally experimentally RB cord-347706-r0rs3ls1 84 27 infected infect VBN cord-347706-r0rs3ls1 84 28 farmed farmed JJ cord-347706-r0rs3ls1 84 29 civet civet NN cord-347706-r0rs3ls1 84 30 cats cat NNS cord-347706-r0rs3ls1 84 31 from from IN cord-347706-r0rs3ls1 84 32 day day NN cord-347706-r0rs3ls1 84 33 3 3 CD cord-347706-r0rs3ls1 84 34 onwards onwards RB cord-347706-r0rs3ls1 84 35 , , , cord-347706-r0rs3ls1 84 36 fever fever NN cord-347706-r0rs3ls1 84 37 from from IN cord-347706-r0rs3ls1 84 38 day day NN cord-347706-r0rs3ls1 84 39 3 3 CD cord-347706-r0rs3ls1 84 40 to to IN cord-347706-r0rs3ls1 84 41 7 7 CD cord-347706-r0rs3ls1 84 42 , , , cord-347706-r0rs3ls1 84 43 and and CC cord-347706-r0rs3ls1 84 44 diarrhea diarrhea NN cord-347706-r0rs3ls1 84 45 and and CC cord-347706-r0rs3ls1 84 46 conjunctivitis conjunctivitis NN cord-347706-r0rs3ls1 84 47 in in IN cord-347706-r0rs3ls1 84 48 20 20 CD cord-347706-r0rs3ls1 84 49 - - SYM cord-347706-r0rs3ls1 84 50 40 40 CD cord-347706-r0rs3ls1 84 51 % % NN cord-347706-r0rs3ls1 84 52 of of IN cord-347706-r0rs3ls1 84 53 animals animal NNS cord-347706-r0rs3ls1 84 54 . . . cord-347706-r0rs3ls1 85 1 The the DT cord-347706-r0rs3ls1 85 2 animals animal NNS cord-347706-r0rs3ls1 85 3 had have VBD cord-347706-r0rs3ls1 85 4 leukopenia leukopenia NN cord-347706-r0rs3ls1 85 5 at at IN cord-347706-r0rs3ls1 85 6 day day NN cord-347706-r0rs3ls1 85 7 3 3 CD cord-347706-r0rs3ls1 85 8 , , , cord-347706-r0rs3ls1 85 9 but but CC cord-347706-r0rs3ls1 85 10 white white JJ cord-347706-r0rs3ls1 85 11 blood blood NN cord-347706-r0rs3ls1 85 12 cell cell NN cord-347706-r0rs3ls1 85 13 counts count NNS cord-347706-r0rs3ls1 85 14 were be VBD cord-347706-r0rs3ls1 85 15 normal normal JJ cord-347706-r0rs3ls1 85 16 by by IN cord-347706-r0rs3ls1 85 17 day day NN cord-347706-r0rs3ls1 85 18 13 13 CD cord-347706-r0rs3ls1 85 19 . . . cord-347706-r0rs3ls1 86 1 Interstitial interstitial JJ cord-347706-r0rs3ls1 86 2 pneumonitis pneumonitis NN cord-347706-r0rs3ls1 86 3 with with IN cord-347706-r0rs3ls1 86 4 alveolar alveolar JJ cord-347706-r0rs3ls1 86 5 septal septal JJ cord-347706-r0rs3ls1 86 6 enlargement enlargement NN cord-347706-r0rs3ls1 86 7 and and CC cord-347706-r0rs3ls1 86 8 macrophages macrophage NNS cord-347706-r0rs3ls1 86 9 and and CC cord-347706-r0rs3ls1 86 10 lymphocyte lymphocyte NN cord-347706-r0rs3ls1 86 11 infiltration infiltration NN cord-347706-r0rs3ls1 86 12 was be VBD cord-347706-r0rs3ls1 86 13 noted note VBN cord-347706-r0rs3ls1 86 14 on on IN cord-347706-r0rs3ls1 86 15 days day NNS cord-347706-r0rs3ls1 86 16 13 13 CD cord-347706-r0rs3ls1 86 17 to to TO cord-347706-r0rs3ls1 86 18 35 35 CD cord-347706-r0rs3ls1 86 19 ; ; : cord-347706-r0rs3ls1 86 20 the the DT cord-347706-r0rs3ls1 86 21 histopathological histopathological JJ cord-347706-r0rs3ls1 86 22 findings finding NNS cord-347706-r0rs3ls1 86 23 are be VBP cord-347706-r0rs3ls1 86 24 reportedly reportedly RB cord-347706-r0rs3ls1 86 25 similar similar JJ cord-347706-r0rs3ls1 86 26 to to IN cord-347706-r0rs3ls1 86 27 lesions lesion NNS cord-347706-r0rs3ls1 86 28 described describe VBN cord-347706-r0rs3ls1 86 29 in in IN cord-347706-r0rs3ls1 86 30 SARS SARS NNP cord-347706-r0rs3ls1 86 31 - - HYPH cord-347706-r0rs3ls1 86 32 CoV CoV NNP cord-347706-r0rs3ls1 86 33 infected infect VBN cord-347706-r0rs3ls1 86 34 macaques macaque NNS cord-347706-r0rs3ls1 86 35 and and CC cord-347706-r0rs3ls1 86 36 experimentally experimentally RB cord-347706-r0rs3ls1 86 37 infected infected JJ cord-347706-r0rs3ls1 86 38 ferrets ferret NNS cord-347706-r0rs3ls1 86 39 . . . cord-347706-r0rs3ls1 87 1 17 17 CD cord-347706-r0rs3ls1 87 2 Virus virus NN cord-347706-r0rs3ls1 87 3 was be VBD cord-347706-r0rs3ls1 87 4 isolated isolate VBN cord-347706-r0rs3ls1 87 5 from from IN cord-347706-r0rs3ls1 87 6 throat throat NN cord-347706-r0rs3ls1 87 7 and and CC cord-347706-r0rs3ls1 87 8 anal anal JJ cord-347706-r0rs3ls1 87 9 swabs swab NNS cord-347706-r0rs3ls1 87 10 in in IN cord-347706-r0rs3ls1 87 11 60 60 CD cord-347706-r0rs3ls1 87 12 % % NN cord-347706-r0rs3ls1 87 13 of of IN cord-347706-r0rs3ls1 87 14 the the DT cord-347706-r0rs3ls1 87 15 animals animal NNS cord-347706-r0rs3ls1 87 16 on on IN cord-347706-r0rs3ls1 87 17 days day NNS cord-347706-r0rs3ls1 87 18 3 3 CD cord-347706-r0rs3ls1 87 19 and and CC cord-347706-r0rs3ls1 87 20 8 8 CD cord-347706-r0rs3ls1 87 21 and and CC cord-347706-r0rs3ls1 87 22 from from IN cord-347706-r0rs3ls1 87 23 organs organ NNS cord-347706-r0rs3ls1 87 24 at at IN cord-347706-r0rs3ls1 87 25 necropsy necropsy JJ cord-347706-r0rs3ls1 87 26 on on IN cord-347706-r0rs3ls1 87 27 day day NN cord-347706-r0rs3ls1 87 28 3 3 CD cord-347706-r0rs3ls1 87 29 ( ( -LRB- cord-347706-r0rs3ls1 87 30 n n NN cord-347706-r0rs3ls1 87 31 = = SYM cord-347706-r0rs3ls1 87 32 1 1 CD cord-347706-r0rs3ls1 87 33 ) ) -RRB- cord-347706-r0rs3ls1 87 34 . . . cord-347706-r0rs3ls1 88 1 Viral viral JJ cord-347706-r0rs3ls1 88 2 nucleic nucleic JJ cord-347706-r0rs3ls1 88 3 acid acid NN cord-347706-r0rs3ls1 88 4 was be VBD cord-347706-r0rs3ls1 88 5 detected detect VBN cord-347706-r0rs3ls1 88 6 by by IN cord-347706-r0rs3ls1 88 7 reverse reverse JJ cord-347706-r0rs3ls1 88 8 transcriptase transcriptase NN cord-347706-r0rs3ls1 88 9 PCR pcr NN cord-347706-r0rs3ls1 88 10 at at IN cord-347706-r0rs3ls1 88 11 necropsy necropsy JJ cord-347706-r0rs3ls1 88 12 in in IN cord-347706-r0rs3ls1 88 13 multiple multiple JJ cord-347706-r0rs3ls1 88 14 organs organ NNS cord-347706-r0rs3ls1 88 15 at at IN cord-347706-r0rs3ls1 88 16 day day NN cord-347706-r0rs3ls1 88 17 3 3 CD cord-347706-r0rs3ls1 88 18 and and CC cord-347706-r0rs3ls1 88 19 in in IN cord-347706-r0rs3ls1 88 20 lymph lymph NN cord-347706-r0rs3ls1 88 21 nodes node NNS cord-347706-r0rs3ls1 88 22 and and CC cord-347706-r0rs3ls1 88 23 spleen spleen NNS cord-347706-r0rs3ls1 88 24 at at IN cord-347706-r0rs3ls1 88 25 days day NNS cord-347706-r0rs3ls1 88 26 13 13 CD cord-347706-r0rs3ls1 88 27 , , , cord-347706-r0rs3ls1 88 28 23 23 CD cord-347706-r0rs3ls1 88 29 , , , cord-347706-r0rs3ls1 88 30 34 34 CD cord-347706-r0rs3ls1 88 31 , , , cord-347706-r0rs3ls1 88 32 and and CC cord-347706-r0rs3ls1 88 33 35 35 CD cord-347706-r0rs3ls1 88 34 . . . cord-347706-r0rs3ls1 89 1 The the DT cord-347706-r0rs3ls1 89 2 findings finding NNS cord-347706-r0rs3ls1 89 3 in in IN cord-347706-r0rs3ls1 89 4 experimentally experimentally RB cord-347706-r0rs3ls1 89 5 infected infect VBN cord-347706-r0rs3ls1 89 6 farmed farm VBN cord-347706-r0rs3ls1 89 7 civets civet NNS cord-347706-r0rs3ls1 89 8 support support VBP cord-347706-r0rs3ls1 89 9 epidemiologic epidemiologic JJ cord-347706-r0rs3ls1 89 10 observations observation NNS cord-347706-r0rs3ls1 89 11 made make VBN cord-347706-r0rs3ls1 89 12 in in IN cord-347706-r0rs3ls1 89 13 wild wild JJ cord-347706-r0rs3ls1 89 14 - - HYPH cord-347706-r0rs3ls1 89 15 animal animal NN cord-347706-r0rs3ls1 89 16 markets market NNS cord-347706-r0rs3ls1 89 17 18 18 CD cord-347706-r0rs3ls1 89 18 that that DT cord-347706-r0rs3ls1 89 19 point point NN cord-347706-r0rs3ls1 89 20 to to IN cord-347706-r0rs3ls1 89 21 civets civet NNS cord-347706-r0rs3ls1 89 22 as as IN cord-347706-r0rs3ls1 89 23 a a DT cord-347706-r0rs3ls1 89 24 potential potential JJ cord-347706-r0rs3ls1 89 25 source source NN cord-347706-r0rs3ls1 89 26 for for IN cord-347706-r0rs3ls1 89 27 the the DT cord-347706-r0rs3ls1 89 28 transmission transmission NN cord-347706-r0rs3ls1 89 29 of of IN cord-347706-r0rs3ls1 89 30 SARS SARS NNP cord-347706-r0rs3ls1 89 31 - - HYPH cord-347706-r0rs3ls1 89 32 CoV CoV NNP cord-347706-r0rs3ls1 89 33 from from IN cord-347706-r0rs3ls1 89 34 animals animal NNS cord-347706-r0rs3ls1 89 35 to to IN cord-347706-r0rs3ls1 89 36 humans human NNS cord-347706-r0rs3ls1 89 37 . . . cord-347706-r0rs3ls1 90 1 However however RB cord-347706-r0rs3ls1 90 2 , , , cord-347706-r0rs3ls1 90 3 further further JJ cord-347706-r0rs3ls1 90 4 research research NN cord-347706-r0rs3ls1 90 5 is be VBZ cord-347706-r0rs3ls1 90 6 required require VBN cord-347706-r0rs3ls1 90 7 to to TO cord-347706-r0rs3ls1 90 8 identify identify VB cord-347706-r0rs3ls1 90 9 the the DT cord-347706-r0rs3ls1 90 10 reservoir(s reservoir(s NNP cord-347706-r0rs3ls1 90 11 ) ) -RRB- cord-347706-r0rs3ls1 90 12 of of IN cord-347706-r0rs3ls1 90 13 SARS SARS NNP cord-347706-r0rs3ls1 90 14 - - HYPH cord-347706-r0rs3ls1 90 15 CoV CoV NNP cord-347706-r0rs3ls1 90 16 in in IN cord-347706-r0rs3ls1 90 17 nature nature NN cord-347706-r0rs3ls1 90 18 . . . cord-347706-r0rs3ls1 91 1 Among among IN cord-347706-r0rs3ls1 91 2 Old old JJ cord-347706-r0rs3ls1 91 3 World World NNP cord-347706-r0rs3ls1 91 4 monkeys monkey NNS cord-347706-r0rs3ls1 91 5 , , , cord-347706-r0rs3ls1 91 6 rhesus rhesu NNS cord-347706-r0rs3ls1 91 7 , , , cord-347706-r0rs3ls1 91 8 cynomolgus cynomolgus NNP cord-347706-r0rs3ls1 91 9 , , , cord-347706-r0rs3ls1 91 10 and and CC cord-347706-r0rs3ls1 91 11 African african JJ cord-347706-r0rs3ls1 91 12 green green JJ cord-347706-r0rs3ls1 91 13 monkeys monkey NNS cord-347706-r0rs3ls1 91 14 have have VBP cord-347706-r0rs3ls1 91 15 been be VBN cord-347706-r0rs3ls1 91 16 experimentally experimentally RB cord-347706-r0rs3ls1 91 17 infected infect VBN cord-347706-r0rs3ls1 91 18 with with IN cord-347706-r0rs3ls1 91 19 SARS SARS NNP cord-347706-r0rs3ls1 91 20 - - HYPH cord-347706-r0rs3ls1 91 21 CoV CoV NNP cord-347706-r0rs3ls1 91 22 and and CC cord-347706-r0rs3ls1 91 23 have have VBP cord-347706-r0rs3ls1 91 24 been be VBN cord-347706-r0rs3ls1 91 25 used use VBN cord-347706-r0rs3ls1 91 26 for for IN cord-347706-r0rs3ls1 91 27 vaccine vaccine NN cord-347706-r0rs3ls1 91 28 immunogenicity immunogenicity NN cord-347706-r0rs3ls1 91 29 and/or and/or CC cord-347706-r0rs3ls1 91 30 efficacy efficacy NN cord-347706-r0rs3ls1 91 31 studies study NNS cord-347706-r0rs3ls1 91 32 . . . cord-347706-r0rs3ls1 92 1 The the DT cord-347706-r0rs3ls1 92 2 presence presence NN cord-347706-r0rs3ls1 92 3 and and CC cord-347706-r0rs3ls1 92 4 extent extent NN cord-347706-r0rs3ls1 92 5 of of IN cord-347706-r0rs3ls1 92 6 clinical clinical JJ cord-347706-r0rs3ls1 92 7 illness illness NN cord-347706-r0rs3ls1 92 8 reported report VBN cord-347706-r0rs3ls1 92 9 in in IN cord-347706-r0rs3ls1 92 10 these these DT cord-347706-r0rs3ls1 92 11 studies study NNS cord-347706-r0rs3ls1 92 12 have have VBP cord-347706-r0rs3ls1 92 13 not not RB cord-347706-r0rs3ls1 92 14 been be VBN cord-347706-r0rs3ls1 92 15 consistent consistent JJ cord-347706-r0rs3ls1 92 16 and and CC cord-347706-r0rs3ls1 92 17 attempts attempt VBZ cord-347706-r0rs3ls1 92 18 to to TO cord-347706-r0rs3ls1 92 19 isolate isolate VB cord-347706-r0rs3ls1 92 20 SARS SARS NNP cord-347706-r0rs3ls1 92 21 - - HYPH cord-347706-r0rs3ls1 92 22 CoV CoV NNP cord-347706-r0rs3ls1 92 23 from from IN cord-347706-r0rs3ls1 92 24 tissues tissue NNS cord-347706-r0rs3ls1 92 25 have have VBP cord-347706-r0rs3ls1 92 26 also also RB cord-347706-r0rs3ls1 92 27 been be VBN cord-347706-r0rs3ls1 92 28 variably variably RB cord-347706-r0rs3ls1 92 29 successful successful JJ cord-347706-r0rs3ls1 93 1 ( ( -LRB- cord-347706-r0rs3ls1 93 2 Table table NN cord-347706-r0rs3ls1 93 3 1 1 CD cord-347706-r0rs3ls1 93 4 ) ) -RRB- cord-347706-r0rs3ls1 93 5 . . . cord-347706-r0rs3ls1 94 1 Clinical clinical JJ cord-347706-r0rs3ls1 94 2 illness illness NN cord-347706-r0rs3ls1 94 3 and and CC cord-347706-r0rs3ls1 94 4 histopathologic histopathologic JJ cord-347706-r0rs3ls1 94 5 findings finding NNS cord-347706-r0rs3ls1 94 6 in in IN cord-347706-r0rs3ls1 94 7 SARS SARS NNP cord-347706-r0rs3ls1 94 8 - - HYPH cord-347706-r0rs3ls1 94 9 CoV CoV NNP cord-347706-r0rs3ls1 94 10 infected infect VBD cord-347706-r0rs3ls1 94 11 cynomolgus cynomolgus NNP cord-347706-r0rs3ls1 94 12 monkeys monkey NNS cord-347706-r0rs3ls1 94 13 range range VBP cord-347706-r0rs3ls1 94 14 from from IN cord-347706-r0rs3ls1 94 15 reports report NNS cord-347706-r0rs3ls1 94 16 of of IN cord-347706-r0rs3ls1 94 17 no no DT cord-347706-r0rs3ls1 94 18 illness illness NN cord-347706-r0rs3ls1 94 19 and and CC cord-347706-r0rs3ls1 94 20 disease disease NN cord-347706-r0rs3ls1 94 21 19 19 CD cord-347706-r0rs3ls1 94 22 , , , cord-347706-r0rs3ls1 94 23 20 20 CD cord-347706-r0rs3ls1 94 24 to to IN cord-347706-r0rs3ls1 94 25 lethargy lethargy NN cord-347706-r0rs3ls1 94 26 , , , cord-347706-r0rs3ls1 94 27 temporary temporary JJ cord-347706-r0rs3ls1 94 28 skin skin NN cord-347706-r0rs3ls1 94 29 rash rash NN cord-347706-r0rs3ls1 94 30 , , , cord-347706-r0rs3ls1 94 31 and and CC cord-347706-r0rs3ls1 94 32 respiratory respiratory JJ cord-347706-r0rs3ls1 94 33 distress distress NN cord-347706-r0rs3ls1 94 34 progressing progress VBG cord-347706-r0rs3ls1 94 35 to to IN cord-347706-r0rs3ls1 94 36 ARDS ARDS NNP cord-347706-r0rs3ls1 94 37 , , , cord-347706-r0rs3ls1 94 38 associated associate VBN cord-347706-r0rs3ls1 94 39 with with IN cord-347706-r0rs3ls1 94 40 diffuse diffuse JJ cord-347706-r0rs3ls1 94 41 alveolar alveolar JJ cord-347706-r0rs3ls1 94 42 damage damage NN cord-347706-r0rs3ls1 94 43 , , , cord-347706-r0rs3ls1 94 44 extensive extensive JJ cord-347706-r0rs3ls1 94 45 loss loss NN cord-347706-r0rs3ls1 94 46 of of IN cord-347706-r0rs3ls1 94 47 epithelium epithelium NN cord-347706-r0rs3ls1 94 48 from from IN cord-347706-r0rs3ls1 94 49 alveolar alveolar NN cord-347706-r0rs3ls1 94 50 and and CC cord-347706-r0rs3ls1 94 51 bronchiolar bronchiolar JJ cord-347706-r0rs3ls1 94 52 walls wall NNS cord-347706-r0rs3ls1 94 53 , , , cord-347706-r0rs3ls1 94 54 thickening thickening NN cord-347706-r0rs3ls1 94 55 of of IN cord-347706-r0rs3ls1 94 56 alveolar alveolar JJ cord-347706-r0rs3ls1 94 57 walls wall NNS cord-347706-r0rs3ls1 94 58 , , , cord-347706-r0rs3ls1 94 59 hyaline hyaline JJ cord-347706-r0rs3ls1 94 60 membranes membrane NNS cord-347706-r0rs3ls1 94 61 in in IN cord-347706-r0rs3ls1 94 62 some some DT cord-347706-r0rs3ls1 94 63 alveoli alveolus NNS cord-347706-r0rs3ls1 94 64 , , , cord-347706-r0rs3ls1 94 65 and and CC cord-347706-r0rs3ls1 94 66 occasional occasional JJ cord-347706-r0rs3ls1 94 67 multinucleated multinucleated JJ cord-347706-r0rs3ls1 94 68 giant giant JJ cord-347706-r0rs3ls1 94 69 cells cell NNS cord-347706-r0rs3ls1 94 70 and and CC cord-347706-r0rs3ls1 94 71 type type NN cord-347706-r0rs3ls1 94 72 2 2 CD cord-347706-r0rs3ls1 94 73 pneumocyte pneumocyte VBN cord-347706-r0rs3ls1 94 74 hyperplasia hyperplasia NN cord-347706-r0rs3ls1 94 75 at at IN cord-347706-r0rs3ls1 94 76 days day NNS cord-347706-r0rs3ls1 94 77 4 4 CD cord-347706-r0rs3ls1 94 78 to to IN cord-347706-r0rs3ls1 94 79 6 6 CD cord-347706-r0rs3ls1 94 80 postinfection postinfection NN cord-347706-r0rs3ls1 94 81 . . . cord-347706-r0rs3ls1 95 1 [ [ -LRB- cord-347706-r0rs3ls1 95 2 21 21 CD cord-347706-r0rs3ls1 95 3 ] ] -RRB- cord-347706-r0rs3ls1 95 4 [ [ -LRB- cord-347706-r0rs3ls1 95 5 22 22 CD cord-347706-r0rs3ls1 95 6 ] ] -RRB- cord-347706-r0rs3ls1 95 7 [ [ -LRB- cord-347706-r0rs3ls1 95 8 23 23 CD cord-347706-r0rs3ls1 95 9 ] ] -RRB- cord-347706-r0rs3ls1 95 10 Clinical clinical JJ cord-347706-r0rs3ls1 95 11 findings finding NNS cord-347706-r0rs3ls1 95 12 in in IN cord-347706-r0rs3ls1 95 13 SARS SARS NNP cord-347706-r0rs3ls1 95 14 - - HYPH cord-347706-r0rs3ls1 95 15 CoV CoV NNP cord-347706-r0rs3ls1 95 16 infected infect VBD cord-347706-r0rs3ls1 95 17 rhesus rhesu NNS cord-347706-r0rs3ls1 95 18 monkeys monkey NNS cord-347706-r0rs3ls1 95 19 are be VBP cord-347706-r0rs3ls1 95 20 absent absent JJ cord-347706-r0rs3ls1 95 21 or or CC cord-347706-r0rs3ls1 95 22 mild mild JJ cord-347706-r0rs3ls1 95 23 . . . cord-347706-r0rs3ls1 96 1 Histopathologic Histopathologic NNP cord-347706-r0rs3ls1 96 2 findings finding NNS cord-347706-r0rs3ls1 96 3 are be VBP cord-347706-r0rs3ls1 96 4 variable variable JJ cord-347706-r0rs3ls1 96 5 , , , cord-347706-r0rs3ls1 96 6 ranging range VBG cord-347706-r0rs3ls1 96 7 from from IN cord-347706-r0rs3ls1 96 8 no no DT cord-347706-r0rs3ls1 96 9 abnormalities abnormality NNS cord-347706-r0rs3ls1 96 10 to to IN cord-347706-r0rs3ls1 96 11 patchy patchy JJ cord-347706-r0rs3ls1 96 12 areas area NNS cord-347706-r0rs3ls1 96 13 of of IN cord-347706-r0rs3ls1 96 14 mild mild JJ cord-347706-r0rs3ls1 96 15 interstitial interstitial JJ cord-347706-r0rs3ls1 96 16 edema edema NN cord-347706-r0rs3ls1 96 17 and and CC cord-347706-r0rs3ls1 96 18 alveolar alveolar JJ cord-347706-r0rs3ls1 96 19 inflammation inflammation NN cord-347706-r0rs3ls1 96 20 interspersed intersperse VBN cord-347706-r0rs3ls1 96 21 with with IN cord-347706-r0rs3ls1 96 22 normal normal JJ cord-347706-r0rs3ls1 96 23 lung lung NN cord-347706-r0rs3ls1 96 24 parenchyma parenchyma NN cord-347706-r0rs3ls1 96 25 and and CC cord-347706-r0rs3ls1 96 26 occasional occasional JJ cord-347706-r0rs3ls1 96 27 areas area NNS cord-347706-r0rs3ls1 96 28 of of IN cord-347706-r0rs3ls1 96 29 intraalveolar intraalveolar NN cord-347706-r0rs3ls1 96 30 edema edema NN cord-347706-r0rs3ls1 96 31 inflammation inflammation NN cord-347706-r0rs3ls1 96 32 at at IN cord-347706-r0rs3ls1 96 33 day day NN cord-347706-r0rs3ls1 96 34 14 14 CD cord-347706-r0rs3ls1 96 35 , , , cord-347706-r0rs3ls1 96 36 in in IN cord-347706-r0rs3ls1 96 37 1 1 CD cord-347706-r0rs3ls1 96 38 of of IN cord-347706-r0rs3ls1 96 39 4 4 CD cord-347706-r0rs3ls1 96 40 animals animal NNS cord-347706-r0rs3ls1 96 41 19 19 CD cord-347706-r0rs3ls1 96 42 to to TO cord-347706-r0rs3ls1 96 43 acute acute JJ cord-347706-r0rs3ls1 96 44 interstitial interstitial JJ cord-347706-r0rs3ls1 96 45 pneumonia pneumonia NN cord-347706-r0rs3ls1 96 46 through through IN cord-347706-r0rs3ls1 96 47 60 60 CD cord-347706-r0rs3ls1 96 48 day day NN cord-347706-r0rs3ls1 96 49 postinfection postinfection NN cord-347706-r0rs3ls1 96 50 with with IN cord-347706-r0rs3ls1 96 51 infiltration infiltration NN cord-347706-r0rs3ls1 96 52 of of IN cord-347706-r0rs3ls1 96 53 lymphocytes lymphocyte NNS cord-347706-r0rs3ls1 96 54 and and CC cord-347706-r0rs3ls1 96 55 macrophages macrophage NNS cord-347706-r0rs3ls1 96 56 in in IN cord-347706-r0rs3ls1 96 57 nodular nodular JJ cord-347706-r0rs3ls1 96 58 areas area NNS cord-347706-r0rs3ls1 96 59 of of IN cord-347706-r0rs3ls1 96 60 lungs lung NNS cord-347706-r0rs3ls1 96 61 . . . cord-347706-r0rs3ls1 97 1 24 24 CD cord-347706-r0rs3ls1 98 1 The the DT cord-347706-r0rs3ls1 98 2 age age NN cord-347706-r0rs3ls1 98 3 of of IN cord-347706-r0rs3ls1 98 4 animals animal NNS cord-347706-r0rs3ls1 98 5 may may MD cord-347706-r0rs3ls1 98 6 be be VB cord-347706-r0rs3ls1 98 7 an an DT cord-347706-r0rs3ls1 98 8 important important JJ cord-347706-r0rs3ls1 98 9 determinant determinant NN cord-347706-r0rs3ls1 98 10 of of IN cord-347706-r0rs3ls1 98 11 outcome outcome NN cord-347706-r0rs3ls1 98 12 that that WDT cord-347706-r0rs3ls1 98 13 can can MD cord-347706-r0rs3ls1 98 14 be be VB cord-347706-r0rs3ls1 98 15 difficult difficult JJ cord-347706-r0rs3ls1 98 16 to to TO cord-347706-r0rs3ls1 98 17 ascertain ascertain VB cord-347706-r0rs3ls1 98 18 in in IN cord-347706-r0rs3ls1 98 19 wild wild NN cord-347706-r0rs3ls1 98 20 - - HYPH cord-347706-r0rs3ls1 98 21 caught catch VBN cord-347706-r0rs3ls1 98 22 monkeys monkey NNS cord-347706-r0rs3ls1 98 23 . . . cord-347706-r0rs3ls1 99 1 In in IN cord-347706-r0rs3ls1 99 2 African african JJ cord-347706-r0rs3ls1 99 3 green green JJ cord-347706-r0rs3ls1 99 4 monkeys monkey NNS cord-347706-r0rs3ls1 99 5 , , , cord-347706-r0rs3ls1 99 6 virus virus NN cord-347706-r0rs3ls1 99 7 infection infection NN cord-347706-r0rs3ls1 99 8 in in IN cord-347706-r0rs3ls1 99 9 the the DT cord-347706-r0rs3ls1 99 10 lungs lung NNS cord-347706-r0rs3ls1 99 11 is be VBZ cord-347706-r0rs3ls1 99 12 patchy patchy JJ cord-347706-r0rs3ls1 99 13 and and CC cord-347706-r0rs3ls1 99 14 is be VBZ cord-347706-r0rs3ls1 99 15 cleared clear VBN cord-347706-r0rs3ls1 99 16 by by IN cord-347706-r0rs3ls1 99 17 day day NN cord-347706-r0rs3ls1 99 18 4 4 CD cord-347706-r0rs3ls1 99 19 post post NN cord-347706-r0rs3ls1 99 20 - - NN cord-347706-r0rs3ls1 99 21 infection infection NN cord-347706-r0rs3ls1 99 22 ; ; : cord-347706-r0rs3ls1 99 23 the the DT cord-347706-r0rs3ls1 99 24 titer titer NN cord-347706-r0rs3ls1 99 25 of of IN cord-347706-r0rs3ls1 99 26 virus virus NN cord-347706-r0rs3ls1 99 27 in in IN cord-347706-r0rs3ls1 99 28 respiratory respiratory JJ cord-347706-r0rs3ls1 99 29 secretions secretion NNS cord-347706-r0rs3ls1 99 30 does do VBZ cord-347706-r0rs3ls1 99 31 not not RB cord-347706-r0rs3ls1 99 32 accurately accurately RB cord-347706-r0rs3ls1 99 33 reflect reflect VB cord-347706-r0rs3ls1 99 34 the the DT cord-347706-r0rs3ls1 99 35 titer titer NN cord-347706-r0rs3ls1 99 36 of of IN cord-347706-r0rs3ls1 99 37 virus virus NN cord-347706-r0rs3ls1 99 38 recovered recover VBN cord-347706-r0rs3ls1 99 39 from from IN cord-347706-r0rs3ls1 99 40 trachea trachea NN cord-347706-r0rs3ls1 99 41 and and CC cord-347706-r0rs3ls1 99 42 lung lung NN cord-347706-r0rs3ls1 99 43 tissue tissue NN cord-347706-r0rs3ls1 99 44 . . . cord-347706-r0rs3ls1 100 1 20 20 CD cord-347706-r0rs3ls1 100 2 Histopathological Histopathological NNP cord-347706-r0rs3ls1 100 3 examination examination NN cord-347706-r0rs3ls1 100 4 of of IN cord-347706-r0rs3ls1 100 5 lungs lung NNS cord-347706-r0rs3ls1 100 6 shows show NNS cord-347706-r0rs3ls1 100 7 diffuse diffuse VBP cord-347706-r0rs3ls1 100 8 alveolar alveolar NN cord-347706-r0rs3ls1 100 9 damage damage NN cord-347706-r0rs3ls1 100 10 and and CC cord-347706-r0rs3ls1 100 11 focal focal JJ cord-347706-r0rs3ls1 100 12 interstitial interstitial JJ cord-347706-r0rs3ls1 100 13 pneumonitis pneumonitis NN cord-347706-r0rs3ls1 100 14 that that WDT cord-347706-r0rs3ls1 100 15 parallels parallel VBZ cord-347706-r0rs3ls1 100 16 virus virus NN cord-347706-r0rs3ls1 100 17 titers titer NNS cord-347706-r0rs3ls1 100 18 in in IN cord-347706-r0rs3ls1 100 19 resolution resolution NN cord-347706-r0rs3ls1 100 20 by by IN cord-347706-r0rs3ls1 100 21 day day NN cord-347706-r0rs3ls1 100 22 4 4 CD cord-347706-r0rs3ls1 100 23 postinfection postinfection NN cord-347706-r0rs3ls1 100 24 . . . cord-347706-r0rs3ls1 101 1 20 20 CD cord-347706-r0rs3ls1 102 1 Three three CD cord-347706-r0rs3ls1 102 2 species specie NNS cord-347706-r0rs3ls1 102 3 of of IN cord-347706-r0rs3ls1 102 4 New new JJ cord-347706-r0rs3ls1 102 5 World World NNP cord-347706-r0rs3ls1 102 6 monkeys monkey NNS cord-347706-r0rs3ls1 102 7 have have VBP cord-347706-r0rs3ls1 102 8 also also RB cord-347706-r0rs3ls1 102 9 been be VBN cord-347706-r0rs3ls1 102 10 evaluated evaluate VBN cord-347706-r0rs3ls1 102 11 as as IN cord-347706-r0rs3ls1 102 12 models model NNS cord-347706-r0rs3ls1 102 13 for for IN cord-347706-r0rs3ls1 102 14 SARS SARS NNP cord-347706-r0rs3ls1 102 15 ( ( -LRB- cord-347706-r0rs3ls1 102 16 Table Table NNP cord-347706-r0rs3ls1 102 17 1 1 CD cord-347706-r0rs3ls1 102 18 ) ) -RRB- cord-347706-r0rs3ls1 102 19 . . . cord-347706-r0rs3ls1 103 1 Although although IN cord-347706-r0rs3ls1 103 2 squirrel squirrel NN cord-347706-r0rs3ls1 103 3 monkeys monkey NNS cord-347706-r0rs3ls1 103 4 and and CC cord-347706-r0rs3ls1 103 5 mustached mustached JJ cord-347706-r0rs3ls1 103 6 tamarins tamarin NNS cord-347706-r0rs3ls1 103 7 could could MD cord-347706-r0rs3ls1 103 8 not not RB cord-347706-r0rs3ls1 103 9 be be VB cord-347706-r0rs3ls1 103 10 experimentally experimentally RB cord-347706-r0rs3ls1 103 11 infected infect VBN cord-347706-r0rs3ls1 103 12 , , , cord-347706-r0rs3ls1 103 13 common common JJ cord-347706-r0rs3ls1 103 14 marmosets marmoset NNS cord-347706-r0rs3ls1 103 15 developed develop VBD cord-347706-r0rs3ls1 103 16 fever fever NN cord-347706-r0rs3ls1 103 17 and and CC cord-347706-r0rs3ls1 103 18 watery watery JJ cord-347706-r0rs3ls1 103 19 diarrhea diarrhea NN cord-347706-r0rs3ls1 103 20 and and CC cord-347706-r0rs3ls1 103 21 histologic histologic JJ cord-347706-r0rs3ls1 103 22 evidence evidence NN cord-347706-r0rs3ls1 103 23 of of IN cord-347706-r0rs3ls1 103 24 multifocal multifocal JJ cord-347706-r0rs3ls1 103 25 pneumonitis pneumonitis NN cord-347706-r0rs3ls1 103 26 and and CC cord-347706-r0rs3ls1 103 27 hepatitis hepatitis NN cord-347706-r0rs3ls1 103 28 following follow VBG cord-347706-r0rs3ls1 103 29 SARS SARS NNP cord-347706-r0rs3ls1 103 30 - - HYPH cord-347706-r0rs3ls1 103 31 CoV CoV NNP cord-347706-r0rs3ls1 103 32 infection infection NN cord-347706-r0rs3ls1 103 33 . . . cord-347706-r0rs3ls1 104 1 25 25 CD cord-347706-r0rs3ls1 105 1 Further further JJ cord-347706-r0rs3ls1 105 2 evaluation evaluation NN cord-347706-r0rs3ls1 105 3 of of IN cord-347706-r0rs3ls1 105 4 this this DT cord-347706-r0rs3ls1 105 5 model model NN cord-347706-r0rs3ls1 105 6 is be VBZ cord-347706-r0rs3ls1 105 7 warranted warrant VBN cord-347706-r0rs3ls1 105 8 . . . cord-347706-r0rs3ls1 106 1 The the DT cord-347706-r0rs3ls1 106 2 detection detection NN cord-347706-r0rs3ls1 106 3 of of IN cord-347706-r0rs3ls1 106 4 viral viral JJ cord-347706-r0rs3ls1 106 5 RNA RNA NNP cord-347706-r0rs3ls1 106 6 and and CC cord-347706-r0rs3ls1 106 7 neutralizing neutralize VBG cord-347706-r0rs3ls1 106 8 antibody antibody NN cord-347706-r0rs3ls1 106 9 responses response NNS cord-347706-r0rs3ls1 106 10 clearly clearly RB cord-347706-r0rs3ls1 106 11 demonstrates demonstrate VBZ cord-347706-r0rs3ls1 106 12 that that IN cord-347706-r0rs3ls1 106 13 several several JJ cord-347706-r0rs3ls1 106 14 species specie NNS cord-347706-r0rs3ls1 106 15 of of IN cord-347706-r0rs3ls1 106 16 nonhuman nonhuman NN cord-347706-r0rs3ls1 106 17 primates primate NNS cord-347706-r0rs3ls1 106 18 can can MD cord-347706-r0rs3ls1 106 19 be be VB cord-347706-r0rs3ls1 106 20 experimentally experimentally RB cord-347706-r0rs3ls1 106 21 infected infect VBN cord-347706-r0rs3ls1 106 22 with with IN cord-347706-r0rs3ls1 106 23 SARS SARS NNP cord-347706-r0rs3ls1 106 24 - - HYPH cord-347706-r0rs3ls1 106 25 CoV. CoV. NNP cord-347706-r0rs3ls1 107 1 Not not RB cord-347706-r0rs3ls1 107 2 surprisingly surprisingly RB cord-347706-r0rs3ls1 107 3 , , , cord-347706-r0rs3ls1 107 4 the the DT cord-347706-r0rs3ls1 107 5 extent extent NN cord-347706-r0rs3ls1 107 6 of of IN cord-347706-r0rs3ls1 107 7 disease disease NN cord-347706-r0rs3ls1 107 8 in in IN cord-347706-r0rs3ls1 107 9 outbred outbred JJ cord-347706-r0rs3ls1 107 10 animals animal NNS cord-347706-r0rs3ls1 107 11 is be VBZ cord-347706-r0rs3ls1 107 12 more more RBR cord-347706-r0rs3ls1 107 13 variable variable JJ cord-347706-r0rs3ls1 107 14 than than IN cord-347706-r0rs3ls1 107 15 in in IN cord-347706-r0rs3ls1 107 16 inbred inbred JJ cord-347706-r0rs3ls1 107 17 animals animal NNS cord-347706-r0rs3ls1 107 18 such such JJ cord-347706-r0rs3ls1 107 19 as as IN cord-347706-r0rs3ls1 107 20 mice mouse NNS cord-347706-r0rs3ls1 107 21 . . . cord-347706-r0rs3ls1 108 1 As as IN cord-347706-r0rs3ls1 108 2 seen see VBN cord-347706-r0rs3ls1 108 3 with with IN cord-347706-r0rs3ls1 108 4 the the DT cord-347706-r0rs3ls1 108 5 other other JJ cord-347706-r0rs3ls1 108 6 animal animal NN cord-347706-r0rs3ls1 108 7 models model NNS cord-347706-r0rs3ls1 108 8 , , , cord-347706-r0rs3ls1 108 9 the the DT cord-347706-r0rs3ls1 108 10 course course NN cord-347706-r0rs3ls1 108 11 of of IN cord-347706-r0rs3ls1 108 12 infection infection NN cord-347706-r0rs3ls1 108 13 in in IN cord-347706-r0rs3ls1 108 14 experimentally experimentally RB cord-347706-r0rs3ls1 108 15 infected infect VBN cord-347706-r0rs3ls1 108 16 nonhuman nonhuman NN cord-347706-r0rs3ls1 108 17 primates primate NNS cord-347706-r0rs3ls1 108 18 is be VBZ cord-347706-r0rs3ls1 108 19 short short JJ cord-347706-r0rs3ls1 108 20 , , , cord-347706-r0rs3ls1 108 21 with with IN cord-347706-r0rs3ls1 108 22 a a DT cord-347706-r0rs3ls1 108 23 rapid rapid JJ cord-347706-r0rs3ls1 108 24 peak peak NN cord-347706-r0rs3ls1 108 25 in in IN cord-347706-r0rs3ls1 108 26 viral viral JJ cord-347706-r0rs3ls1 108 27 replication replication NN cord-347706-r0rs3ls1 108 28 and and CC cord-347706-r0rs3ls1 108 29 clearance clearance NN cord-347706-r0rs3ls1 108 30 of of IN cord-347706-r0rs3ls1 108 31 virus virus NN cord-347706-r0rs3ls1 108 32 from from IN cord-347706-r0rs3ls1 108 33 the the DT cord-347706-r0rs3ls1 108 34 lungs lung NNS cord-347706-r0rs3ls1 108 35 by by IN cord-347706-r0rs3ls1 108 36 days day NNS cord-347706-r0rs3ls1 108 37 4 4 CD cord-347706-r0rs3ls1 108 38 to to TO cord-347706-r0rs3ls1 108 39 7 7 CD cord-347706-r0rs3ls1 108 40 in in IN cord-347706-r0rs3ls1 108 41 different different JJ cord-347706-r0rs3ls1 108 42 species specie NNS cord-347706-r0rs3ls1 108 43 . . . cord-347706-r0rs3ls1 109 1 Histopathologic Histopathologic NNP cord-347706-r0rs3ls1 109 2 changes change NNS cord-347706-r0rs3ls1 109 3 also also RB cord-347706-r0rs3ls1 109 4 resolved resolve VBD cord-347706-r0rs3ls1 109 5 rapidly rapidly RB cord-347706-r0rs3ls1 109 6 in in IN cord-347706-r0rs3ls1 109 7 all all DT cord-347706-r0rs3ls1 109 8 but but IN cord-347706-r0rs3ls1 109 9 one one CD cord-347706-r0rs3ls1 109 10 study study NN cord-347706-r0rs3ls1 109 11 . . . cord-347706-r0rs3ls1 110 1 24 24 CD cord-347706-r0rs3ls1 111 1 The the DT cord-347706-r0rs3ls1 111 2 absence absence NN cord-347706-r0rs3ls1 111 3 of of IN cord-347706-r0rs3ls1 111 4 consistently consistently RB cord-347706-r0rs3ls1 111 5 observed observe VBN cord-347706-r0rs3ls1 111 6 clinical clinical JJ cord-347706-r0rs3ls1 111 7 illness illness NN cord-347706-r0rs3ls1 111 8 and and CC cord-347706-r0rs3ls1 111 9 the the DT cord-347706-r0rs3ls1 111 10 rapid rapid JJ cord-347706-r0rs3ls1 111 11 resolution resolution NN cord-347706-r0rs3ls1 111 12 of of IN cord-347706-r0rs3ls1 111 13 viral viral JJ cord-347706-r0rs3ls1 111 14 infection infection NN cord-347706-r0rs3ls1 111 15 and and CC cord-347706-r0rs3ls1 111 16 468 468 CD cord-347706-r0rs3ls1 111 17 hepatitis hepatitis NN cord-347706-r0rs3ls1 111 18 at at IN cord-347706-r0rs3ls1 111 19 day day NN cord-347706-r0rs3ls1 111 20 7 7 CD cord-347706-r0rs3ls1 111 21 and and CC cord-347706-r0rs3ls1 111 22 associated associate VBD cord-347706-r0rs3ls1 111 23 pulmonary pulmonary JJ cord-347706-r0rs3ls1 111 24 pathology pathology NN cord-347706-r0rs3ls1 111 25 may may MD cord-347706-r0rs3ls1 111 26 limit limit VB cord-347706-r0rs3ls1 111 27 the the DT cord-347706-r0rs3ls1 111 28 role role NN cord-347706-r0rs3ls1 111 29 of of IN cord-347706-r0rs3ls1 111 30 nonhuman nonhuman NN cord-347706-r0rs3ls1 111 31 primates primate NNS cord-347706-r0rs3ls1 111 32 to to IN cord-347706-r0rs3ls1 111 33 studies study NNS cord-347706-r0rs3ls1 111 34 of of IN cord-347706-r0rs3ls1 111 35 the the DT cord-347706-r0rs3ls1 111 36 immunogenicity immunogenicity NN cord-347706-r0rs3ls1 111 37 of of IN cord-347706-r0rs3ls1 111 38 vaccines vaccine NNS cord-347706-r0rs3ls1 111 39 and and CC cord-347706-r0rs3ls1 111 40 antivirals antiviral NNS cord-347706-r0rs3ls1 111 41 rather rather RB cord-347706-r0rs3ls1 111 42 than than IN cord-347706-r0rs3ls1 111 43 pathogenesis pathogenesis NN cord-347706-r0rs3ls1 111 44 or or CC cord-347706-r0rs3ls1 111 45 efficacy efficacy NN cord-347706-r0rs3ls1 111 46 studies study NNS cord-347706-r0rs3ls1 111 47 . . . cord-347706-r0rs3ls1 112 1 species specie NNS cord-347706-r0rs3ls1 112 2 can can MD cord-347706-r0rs3ls1 112 3 support support VB cord-347706-r0rs3ls1 112 4 replication replication NN cord-347706-r0rs3ls1 112 5 of of IN cord-347706-r0rs3ls1 112 6 SARS SARS NNP cord-347706-r0rs3ls1 112 7 - - HYPH cord-347706-r0rs3ls1 112 8 CoV CoV NNP cord-347706-r0rs3ls1 112 9 with with IN cord-347706-r0rs3ls1 112 10 or or CC cord-347706-r0rs3ls1 112 11 without without IN cord-347706-r0rs3ls1 112 12 accompanying accompany VBG cord-347706-r0rs3ls1 112 13 clinical clinical JJ cord-347706-r0rs3ls1 112 14 illness illness NN cord-347706-r0rs3ls1 112 15 or or CC cord-347706-r0rs3ls1 112 16 pulmonary pulmonary JJ cord-347706-r0rs3ls1 112 17 pathology pathology NN cord-347706-r0rs3ls1 112 18 . . . cord-347706-r0rs3ls1 113 1 Each each DT cord-347706-r0rs3ls1 113 2 model model NN cord-347706-r0rs3ls1 113 3 has have VBZ cord-347706-r0rs3ls1 113 4 advantages advantage NNS cord-347706-r0rs3ls1 113 5 and and CC cord-347706-r0rs3ls1 113 6 disadvantages disadvantage NNS cord-347706-r0rs3ls1 113 7 ( ( -LRB- cord-347706-r0rs3ls1 113 8 Table table NN cord-347706-r0rs3ls1 113 9 2 2 CD cord-347706-r0rs3ls1 113 10 ) ) -RRB- cord-347706-r0rs3ls1 113 11 but but CC cord-347706-r0rs3ls1 113 12 the the DT cord-347706-r0rs3ls1 113 13 common common JJ cord-347706-r0rs3ls1 113 14 themes theme NNS cord-347706-r0rs3ls1 113 15 are be VBP cord-347706-r0rs3ls1 113 16 that that IN cord-347706-r0rs3ls1 113 17 a a DT cord-347706-r0rs3ls1 113 18 number number NN cord-347706-r0rs3ls1 113 19 of of IN cord-347706-r0rs3ls1 113 20 animal animal NN cord-347706-r0rs3ls1 113 21 species specie NNS cord-347706-r0rs3ls1 113 22 can can MD cord-347706-r0rs3ls1 113 23 be be VB cord-347706-r0rs3ls1 113 24 infected infect VBN cord-347706-r0rs3ls1 113 25 when when WRB cord-347706-r0rs3ls1 113 26 SARS SARS NNP cord-347706-r0rs3ls1 113 27 - - HYPH cord-347706-r0rs3ls1 113 28 CoV CoV NNP cord-347706-r0rs3ls1 113 29 is be VBZ cord-347706-r0rs3ls1 113 30 delivered deliver VBN cord-347706-r0rs3ls1 113 31 into into IN cord-347706-r0rs3ls1 113 32 the the DT cord-347706-r0rs3ls1 113 33 respiratory respiratory JJ cord-347706-r0rs3ls1 113 34 tract tract NN cord-347706-r0rs3ls1 113 35 , , , cord-347706-r0rs3ls1 113 36 the the DT cord-347706-r0rs3ls1 113 37 infection infection NN cord-347706-r0rs3ls1 113 38 elicits elicit VBZ cord-347706-r0rs3ls1 113 39 a a DT cord-347706-r0rs3ls1 113 40 neutralizing neutralize VBG cord-347706-r0rs3ls1 113 41 antibody antibody NN cord-347706-r0rs3ls1 113 42 response response NN cord-347706-r0rs3ls1 113 43 and and CC cord-347706-r0rs3ls1 113 44 the the DT cord-347706-r0rs3ls1 113 45 animals animal NNS cord-347706-r0rs3ls1 113 46 are be VBP cord-347706-r0rs3ls1 113 47 protected protect VBN cord-347706-r0rs3ls1 113 48 from from IN cord-347706-r0rs3ls1 113 49 subsequent subsequent JJ cord-347706-r0rs3ls1 113 50 infection infection NN cord-347706-r0rs3ls1 113 51 . . . cord-347706-r0rs3ls1 114 1 In in IN cord-347706-r0rs3ls1 114 2 comparing compare VBG cord-347706-r0rs3ls1 114 3 reports report NNS cord-347706-r0rs3ls1 114 4 , , , cord-347706-r0rs3ls1 114 5 readers reader NNS cord-347706-r0rs3ls1 114 6 should should MD cord-347706-r0rs3ls1 114 7 bear bear VB cord-347706-r0rs3ls1 114 8 in in IN cord-347706-r0rs3ls1 114 9 mind mind NN cord-347706-r0rs3ls1 114 10 that that IN cord-347706-r0rs3ls1 114 11 the the DT cord-347706-r0rs3ls1 114 12 virus virus NN cord-347706-r0rs3ls1 114 13 used use VBN cord-347706-r0rs3ls1 114 14 , , , cord-347706-r0rs3ls1 114 15 inoculum inoculum NN cord-347706-r0rs3ls1 114 16 and and CC cord-347706-r0rs3ls1 114 17 route route NN cord-347706-r0rs3ls1 114 18 of of IN cord-347706-r0rs3ls1 114 19 virus virus NN cord-347706-r0rs3ls1 114 20 administration administration NN cord-347706-r0rs3ls1 114 21 and and CC cord-347706-r0rs3ls1 114 22 age age NN cord-347706-r0rs3ls1 114 23 of of IN cord-347706-r0rs3ls1 114 24 the the DT cord-347706-r0rs3ls1 114 25 animal animal NN cord-347706-r0rs3ls1 114 26 may may MD cord-347706-r0rs3ls1 114 27 represent represent VB cord-347706-r0rs3ls1 114 28 important important JJ cord-347706-r0rs3ls1 114 29 differences difference NNS cord-347706-r0rs3ls1 114 30 . . . cord-347706-r0rs3ls1 115 1 In in IN cord-347706-r0rs3ls1 115 2 studies study NNS cord-347706-r0rs3ls1 115 3 in in IN cord-347706-r0rs3ls1 115 4 mice mouse NNS cord-347706-r0rs3ls1 115 5 , , , cord-347706-r0rs3ls1 115 6 the the DT cord-347706-r0rs3ls1 115 7 age age NN cord-347706-r0rs3ls1 115 8 of of IN cord-347706-r0rs3ls1 115 9 the the DT cord-347706-r0rs3ls1 115 10 animals animal NNS cord-347706-r0rs3ls1 115 11 and and CC cord-347706-r0rs3ls1 115 12 use use NN cord-347706-r0rs3ls1 115 13 of of IN cord-347706-r0rs3ls1 115 14 anesthesia anesthesia NN cord-347706-r0rs3ls1 115 15 clearly clearly RB cord-347706-r0rs3ls1 115 16 affect affect VBP cord-347706-r0rs3ls1 115 17 the the DT cord-347706-r0rs3ls1 115 18 course course NN cord-347706-r0rs3ls1 115 19 of of IN cord-347706-r0rs3ls1 115 20 infection infection NN cord-347706-r0rs3ls1 115 21 . . . cord-347706-r0rs3ls1 116 1 The the DT cord-347706-r0rs3ls1 116 2 characteristics characteristic NNS cord-347706-r0rs3ls1 116 3 of of IN cord-347706-r0rs3ls1 116 4 each each DT cord-347706-r0rs3ls1 116 5 model model NN cord-347706-r0rs3ls1 116 6 should should MD cord-347706-r0rs3ls1 116 7 be be VB cord-347706-r0rs3ls1 116 8 taken take VBN cord-347706-r0rs3ls1 116 9 into into IN cord-347706-r0rs3ls1 116 10 consideration consideration NN cord-347706-r0rs3ls1 116 11 in in IN cord-347706-r0rs3ls1 116 12 determining determine VBG cord-347706-r0rs3ls1 116 13 their -PRON- PRP$ cord-347706-r0rs3ls1 116 14 utility utility NN cord-347706-r0rs3ls1 116 15 and and CC cord-347706-r0rs3ls1 116 16 application application NN cord-347706-r0rs3ls1 116 17 . . . cord-347706-r0rs3ls1 117 1 Table table NN cord-347706-r0rs3ls1 117 2 3 3 CD cord-347706-r0rs3ls1 117 3 lists list VBZ cord-347706-r0rs3ls1 117 4 potential potential JJ cord-347706-r0rs3ls1 117 5 uses use NNS cord-347706-r0rs3ls1 117 6 of of IN cord-347706-r0rs3ls1 117 7 the the DT cord-347706-r0rs3ls1 117 8 models model NNS cord-347706-r0rs3ls1 117 9 discussed discuss VBN cord-347706-r0rs3ls1 117 10 above above RB cord-347706-r0rs3ls1 117 11 . . . cord-347706-r0rs3ls1 118 1 We -PRON- PRP cord-347706-r0rs3ls1 118 2 thank thank VBP cord-347706-r0rs3ls1 118 3 our -PRON- PRP$ cord-347706-r0rs3ls1 118 4 colleagues colleague NNS cord-347706-r0rs3ls1 118 5 Leatrice Leatrice NNP cord-347706-r0rs3ls1 118 6 Vogel Vogel NNP cord-347706-r0rs3ls1 118 7 , , , cord-347706-r0rs3ls1 118 8 Elaine Elaine NNP cord-347706-r0rs3ls1 118 9 Lamirande Lamirande NNP cord-347706-r0rs3ls1 118 10 , , , cord-347706-r0rs3ls1 118 11 Josephine Josephine NNP cord-347706-r0rs3ls1 118 12 McAuliffe McAuliffe NNP cord-347706-r0rs3ls1 118 13 , , , cord-347706-r0rs3ls1 118 14 Brian Brian NNP cord-347706-r0rs3ls1 118 15 Murphy Murphy NNP cord-347706-r0rs3ls1 118 16 , , , cord-347706-r0rs3ls1 118 17 Jun Jun NNP cord-347706-r0rs3ls1 118 18 Chen Chen NNP cord-347706-r0rs3ls1 118 19 , , , cord-347706-r0rs3ls1 118 20 Jadon Jadon NNP cord-347706-r0rs3ls1 118 21 Jackson Jackson NNP cord-347706-r0rs3ls1 118 22 , , , cord-347706-r0rs3ls1 118 23 and and CC cord-347706-r0rs3ls1 118 24 Aaron Aaron NNP cord-347706-r0rs3ls1 118 25 Cheng Cheng NNP cord-347706-r0rs3ls1 118 26 at at IN cord-347706-r0rs3ls1 118 27 the the DT cord-347706-r0rs3ls1 118 28 NIH NIH NNP cord-347706-r0rs3ls1 118 29 , , , cord-347706-r0rs3ls1 118 30 Sherif Sherif NNP cord-347706-r0rs3ls1 118 31 Zaki Zaki NNP cord-347706-r0rs3ls1 118 32 , , , cord-347706-r0rs3ls1 118 33 Christopher Christopher NNP cord-347706-r0rs3ls1 118 34 Paddock Paddock NNP cord-347706-r0rs3ls1 118 35 , , , cord-347706-r0rs3ls1 118 36 Jeannette Jeannette NNP cord-347706-r0rs3ls1 118 37 Guarner Guarner NNP cord-347706-r0rs3ls1 118 38 , , , cord-347706-r0rs3ls1 118 39 and and CC cord-347706-r0rs3ls1 118 40 Wun Wun NNP cord-347706-r0rs3ls1 118 41 - - HYPH cord-347706-r0rs3ls1 118 42 Ju Ju NNP cord-347706-r0rs3ls1 118 43 Shieh Shieh NNP cord-347706-r0rs3ls1 118 44 in in IN cord-347706-r0rs3ls1 118 45 the the DT cord-347706-r0rs3ls1 118 46 Infectious Infectious NNP cord-347706-r0rs3ls1 118 47 Disease Disease NNP cord-347706-r0rs3ls1 118 48 Pathology Pathology NNP cord-347706-r0rs3ls1 118 49 Activity Activity NNP cord-347706-r0rs3ls1 118 50 at at IN cord-347706-r0rs3ls1 118 51 the the DT cord-347706-r0rs3ls1 118 52 CDC CDC NNP cord-347706-r0rs3ls1 118 53 , , , cord-347706-r0rs3ls1 118 54 and and CC cord-347706-r0rs3ls1 118 55 Marisa Marisa NNP cord-347706-r0rs3ls1 118 56 St. St. NNP cord-347706-r0rs3ls1 118 57 Claire Claire NNP cord-347706-r0rs3ls1 118 58 at at IN cord-347706-r0rs3ls1 118 59 Bioqual Bioqual NNP cord-347706-r0rs3ls1 118 60 Inc. Inc. NNP cord-347706-r0rs3ls1 118 61 who who WP cord-347706-r0rs3ls1 118 62 have have VBP cord-347706-r0rs3ls1 118 63 participated participate VBN cord-347706-r0rs3ls1 118 64 in in IN cord-347706-r0rs3ls1 118 65 our -PRON- PRP$ cord-347706-r0rs3ls1 118 66 efforts effort NNS cord-347706-r0rs3ls1 118 67 to to TO cord-347706-r0rs3ls1 118 68 evaluate evaluate VB cord-347706-r0rs3ls1 118 69 several several JJ cord-347706-r0rs3ls1 118 70 animal animal NN cord-347706-r0rs3ls1 118 71 models model NNS cord-347706-r0rs3ls1 118 72 for for IN cord-347706-r0rs3ls1 118 73 SARS SARS NNP cord-347706-r0rs3ls1 118 74 . . . cord-347706-r0rs3ls1 119 1 This this DT cord-347706-r0rs3ls1 119 2 research research NN cord-347706-r0rs3ls1 119 3 was be VBD cord-347706-r0rs3ls1 119 4 supported support VBN cord-347706-r0rs3ls1 119 5 in in IN cord-347706-r0rs3ls1 119 6 part part NN cord-347706-r0rs3ls1 119 7 by by IN cord-347706-r0rs3ls1 119 8 the the DT cord-347706-r0rs3ls1 119 9 Intramural Intramural NNP cord-347706-r0rs3ls1 119 10 Research Research NNP cord-347706-r0rs3ls1 119 11 Program Program NNP cord-347706-r0rs3ls1 119 12 of of IN cord-347706-r0rs3ls1 119 13 the the DT cord-347706-r0rs3ls1 119 14 NIAID NIAID NNP cord-347706-r0rs3ls1 119 15 , , , cord-347706-r0rs3ls1 119 16 NIH NIH NNP cord-347706-r0rs3ls1 119 17 . . . cord-347706-r0rs3ls1 119 18 _SP cord-347706-r0rs3ls1 120 1 Prior prior JJ cord-347706-r0rs3ls1 120 2 infection infection NN cord-347706-r0rs3ls1 120 3 and and CC cord-347706-r0rs3ls1 120 4 passive passive JJ cord-347706-r0rs3ls1 120 5 transfer transfer NN cord-347706-r0rs3ls1 120 6 of of IN cord-347706-r0rs3ls1 120 7 neutralizing neutralize VBG cord-347706-r0rs3ls1 120 8 antibody antibody NN cord-347706-r0rs3ls1 120 9 prevent prevent VB cord-347706-r0rs3ls1 120 10 replication replication NN cord-347706-r0rs3ls1 120 11 of of IN cord-347706-r0rs3ls1 120 12 severe severe JJ cord-347706-r0rs3ls1 120 13 acute acute JJ cord-347706-r0rs3ls1 120 14 respiratory respiratory JJ cord-347706-r0rs3ls1 120 15 syndrome syndrome NN cord-347706-r0rs3ls1 120 16 coronavirus coronavirus NN cord-347706-r0rs3ls1 120 17 in in IN cord-347706-r0rs3ls1 120 18 the the DT cord-347706-r0rs3ls1 120 19 respiratory respiratory JJ cord-347706-r0rs3ls1 120 20 tract tract NN cord-347706-r0rs3ls1 120 21 of of IN cord-347706-r0rs3ls1 120 22 mice mouse NNS cord-347706-r0rs3ls1 120 23 Mice mouse NNS cord-347706-r0rs3ls1 120 24 susceptible susceptible JJ cord-347706-r0rs3ls1 120 25 to to IN cord-347706-r0rs3ls1 120 26 SARS SARS NNP cord-347706-r0rs3ls1 120 27 coronavirus coronavirus NN cord-347706-r0rs3ls1 120 28 Mechanisms Mechanisms NNPS cord-347706-r0rs3ls1 120 29 of of IN cord-347706-r0rs3ls1 120 30 host host NN cord-347706-r0rs3ls1 120 31 defense defense NN cord-347706-r0rs3ls1 120 32 following follow VBG cord-347706-r0rs3ls1 121 1 severe severe JJ cord-347706-r0rs3ls1 121 2 acute acute JJ cord-347706-r0rs3ls1 121 3 respiratory respiratory JJ cord-347706-r0rs3ls1 121 4 syndrome syndrome NN cord-347706-r0rs3ls1 121 5 - - HYPH cord-347706-r0rs3ls1 121 6 coronavirus coronavirus NN cord-347706-r0rs3ls1 121 7 ( ( -LRB- cord-347706-r0rs3ls1 121 8 SARS SARS NNP cord-347706-r0rs3ls1 121 9 - - HYPH cord-347706-r0rs3ls1 121 10 CoV CoV NNP cord-347706-r0rs3ls1 121 11 ) ) -RRB- cord-347706-r0rs3ls1 121 12 pulmonary pulmonary JJ cord-347706-r0rs3ls1 121 13 infection infection NN cord-347706-r0rs3ls1 121 14 of of IN cord-347706-r0rs3ls1 121 15 mice mouse NNS cord-347706-r0rs3ls1 121 16 Resolution resolution NN cord-347706-r0rs3ls1 121 17 of of IN cord-347706-r0rs3ls1 121 18 primary primary JJ cord-347706-r0rs3ls1 121 19 severe severe JJ cord-347706-r0rs3ls1 121 20 acute acute JJ cord-347706-r0rs3ls1 121 21 respiratory respiratory JJ cord-347706-r0rs3ls1 121 22 syndrome syndrome NN cord-347706-r0rs3ls1 121 23 - - HYPH cord-347706-r0rs3ls1 121 24 associated associate VBN cord-347706-r0rs3ls1 121 25 coronavirus coronavirus NN cord-347706-r0rs3ls1 121 26 infection infection NN cord-347706-r0rs3ls1 121 27 requires require VBZ cord-347706-r0rs3ls1 121 28 Stat1 Stat1 NNS cord-347706-r0rs3ls1 122 1 Aged aged JJ cord-347706-r0rs3ls1 122 2 BALB BALB NNP cord-347706-r0rs3ls1 122 3 / / SYM cord-347706-r0rs3ls1 122 4 c c NN cord-347706-r0rs3ls1 122 5 mice mouse NNS cord-347706-r0rs3ls1 122 6 as as IN cord-347706-r0rs3ls1 122 7 a a DT cord-347706-r0rs3ls1 122 8 model model NN cord-347706-r0rs3ls1 122 9 for for IN cord-347706-r0rs3ls1 122 10 increased increase VBN cord-347706-r0rs3ls1 122 11 severity severity NN cord-347706-r0rs3ls1 122 12 of of IN cord-347706-r0rs3ls1 122 13 severe severe JJ cord-347706-r0rs3ls1 122 14 acute acute JJ cord-347706-r0rs3ls1 122 15 respiratory respiratory JJ cord-347706-r0rs3ls1 122 16 syndrome syndrome NN cord-347706-r0rs3ls1 122 17 in in IN cord-347706-r0rs3ls1 122 18 elderly elderly JJ cord-347706-r0rs3ls1 122 19 humans human NNS cord-347706-r0rs3ls1 123 1 Severe severe JJ cord-347706-r0rs3ls1 123 2 acute acute JJ cord-347706-r0rs3ls1 123 3 respiratory respiratory JJ cord-347706-r0rs3ls1 123 4 syndrome syndrome NN cord-347706-r0rs3ls1 123 5 coronavirus coronavirus NN cord-347706-r0rs3ls1 123 6 spike spike NN cord-347706-r0rs3ls1 123 7 protein protein NN cord-347706-r0rs3ls1 123 8 expressed express VBN cord-347706-r0rs3ls1 123 9 by by IN cord-347706-r0rs3ls1 123 10 attenuated attenuated JJ cord-347706-r0rs3ls1 123 11 vaccinia vaccinia NN cord-347706-r0rs3ls1 123 12 virus virus NN cord-347706-r0rs3ls1 123 13 protectively protectively RB cord-347706-r0rs3ls1 123 14 immunizes immunize VBZ cord-347706-r0rs3ls1 123 15 mice mouse NNS cord-347706-r0rs3ls1 123 16 Neutralizing neutralize VBG cord-347706-r0rs3ls1 123 17 antibody antibody NN cord-347706-r0rs3ls1 123 18 and and CC cord-347706-r0rs3ls1 123 19 protective protective JJ cord-347706-r0rs3ls1 123 20 immunity immunity NN cord-347706-r0rs3ls1 123 21 to to IN cord-347706-r0rs3ls1 123 22 SARS SARS NNP cord-347706-r0rs3ls1 123 23 coronavirus coronavirus NN cord-347706-r0rs3ls1 123 24 infection infection NN cord-347706-r0rs3ls1 123 25 of of IN cord-347706-r0rs3ls1 123 26 mice mouse NNS cord-347706-r0rs3ls1 123 27 induced induce VBN cord-347706-r0rs3ls1 123 28 by by IN cord-347706-r0rs3ls1 123 29 a a DT cord-347706-r0rs3ls1 123 30 soluble soluble JJ cord-347706-r0rs3ls1 123 31 recombinant recombinant JJ cord-347706-r0rs3ls1 123 32 polypeptide polypeptide NN cord-347706-r0rs3ls1 123 33 containing contain VBG cord-347706-r0rs3ls1 123 34 an an DT cord-347706-r0rs3ls1 123 35 Nterminal Nterminal NNP cord-347706-r0rs3ls1 123 36 segment segment NN cord-347706-r0rs3ls1 123 37 of of IN cord-347706-r0rs3ls1 123 38 the the DT cord-347706-r0rs3ls1 123 39 spike spike NN cord-347706-r0rs3ls1 123 40 glycoprotein glycoprotein NN cord-347706-r0rs3ls1 123 41 Rapid rapid JJ cord-347706-r0rs3ls1 123 42 and and CC cord-347706-r0rs3ls1 123 43 efficient efficient JJ cord-347706-r0rs3ls1 123 44 isolation isolation NN cord-347706-r0rs3ls1 123 45 of of IN cord-347706-r0rs3ls1 123 46 human human JJ cord-347706-r0rs3ls1 123 47 monoclonal monoclonal JJ cord-347706-r0rs3ls1 123 48 antibodies antibody NNS cord-347706-r0rs3ls1 123 49 neutralizing neutralize VBG cord-347706-r0rs3ls1 123 50 SARS SARS NNP cord-347706-r0rs3ls1 123 51 coronavirus coronavirus NN cord-347706-r0rs3ls1 123 52 from from IN cord-347706-r0rs3ls1 123 53 human human JJ cord-347706-r0rs3ls1 123 54 memory memory NN cord-347706-r0rs3ls1 123 55 B B NNP cord-347706-r0rs3ls1 123 56 cells cell NNS cord-347706-r0rs3ls1 124 1 A a DT cord-347706-r0rs3ls1 124 2 DNA dna NN cord-347706-r0rs3ls1 124 3 vaccine vaccine NN cord-347706-r0rs3ls1 124 4 induces induce VBZ cord-347706-r0rs3ls1 124 5 SARS SARS NNP cord-347706-r0rs3ls1 124 6 coronavirus coronavirus NN cord-347706-r0rs3ls1 124 7 neutralization neutralization NN cord-347706-r0rs3ls1 124 8 and and CC cord-347706-r0rs3ls1 124 9 protective protective JJ cord-347706-r0rs3ls1 124 10 immunity immunity NN cord-347706-r0rs3ls1 124 11 in in IN cord-347706-r0rs3ls1 124 12 mice mouse NNS cord-347706-r0rs3ls1 124 13 Evaluation Evaluation NNP cord-347706-r0rs3ls1 124 14 of of IN cord-347706-r0rs3ls1 124 15 human human JJ cord-347706-r0rs3ls1 124 16 monoclonal monoclonal JJ cord-347706-r0rs3ls1 124 17 antibody antibody NN cord-347706-r0rs3ls1 124 18 80R 80R NNP cord-347706-r0rs3ls1 124 19 for for IN cord-347706-r0rs3ls1 124 20 immunoprophylaxis immunoprophylaxis NNP cord-347706-r0rs3ls1 124 21 of of IN cord-347706-r0rs3ls1 124 22 severe severe JJ cord-347706-r0rs3ls1 124 23 acute acute JJ cord-347706-r0rs3ls1 124 24 respiratory respiratory JJ cord-347706-r0rs3ls1 124 25 syndrome syndrome NN cord-347706-r0rs3ls1 124 26 by by IN cord-347706-r0rs3ls1 124 27 an an DT cord-347706-r0rs3ls1 124 28 animal animal NN cord-347706-r0rs3ls1 124 29 study study NN cord-347706-r0rs3ls1 124 30 , , , cord-347706-r0rs3ls1 124 31 epitope epitope NN cord-347706-r0rs3ls1 124 32 mapping mapping NN cord-347706-r0rs3ls1 124 33 , , , cord-347706-r0rs3ls1 124 34 and and CC cord-347706-r0rs3ls1 124 35 analysis analysis NN cord-347706-r0rs3ls1 124 36 of of IN cord-347706-r0rs3ls1 124 37 spike spike NN cord-347706-r0rs3ls1 124 38 variants variant NNS cord-347706-r0rs3ls1 124 39 Development development NN cord-347706-r0rs3ls1 124 40 and and CC cord-347706-r0rs3ls1 124 41 characterization characterization NN cord-347706-r0rs3ls1 124 42 of of IN cord-347706-r0rs3ls1 124 43 a a DT cord-347706-r0rs3ls1 124 44 severe severe JJ cord-347706-r0rs3ls1 124 45 acute acute JJ cord-347706-r0rs3ls1 124 46 respiratory respiratory JJ cord-347706-r0rs3ls1 124 47 syndrome syndrome NN cord-347706-r0rs3ls1 124 48 - - HYPH cord-347706-r0rs3ls1 124 49 associated associate VBN cord-347706-r0rs3ls1 124 50 coronavirus coronavirus NN cord-347706-r0rs3ls1 124 51 - - HYPH cord-347706-r0rs3ls1 124 52 neutralizing neutralize VBG cord-347706-r0rs3ls1 124 53 human human JJ cord-347706-r0rs3ls1 124 54 monoclonal monoclonal JJ cord-347706-r0rs3ls1 124 55 antibody antibody NN cord-347706-r0rs3ls1 124 56 that that WDT cord-347706-r0rs3ls1 124 57 provides provide VBZ cord-347706-r0rs3ls1 124 58 effective effective JJ cord-347706-r0rs3ls1 124 59 immunoprophylaxis immunoprophylaxis NN cord-347706-r0rs3ls1 124 60 in in IN cord-347706-r0rs3ls1 124 61 mice mice NN cord-347706-r0rs3ls1 124 62 Long long JJ cord-347706-r0rs3ls1 124 63 - - HYPH cord-347706-r0rs3ls1 124 64 term term NN cord-347706-r0rs3ls1 124 65 protection protection NN cord-347706-r0rs3ls1 124 66 from from IN cord-347706-r0rs3ls1 124 67 SARS SARS NNP cord-347706-r0rs3ls1 124 68 coronavirus coronavirus NN cord-347706-r0rs3ls1 124 69 infection infection NN cord-347706-r0rs3ls1 124 70 conferred confer VBN cord-347706-r0rs3ls1 124 71 by by IN cord-347706-r0rs3ls1 124 72 a a DT cord-347706-r0rs3ls1 124 73 single single JJ cord-347706-r0rs3ls1 124 74 immunization immunization NN cord-347706-r0rs3ls1 124 75 with with IN cord-347706-r0rs3ls1 124 76 an an DT cord-347706-r0rs3ls1 124 77 attenuated attenuated JJ cord-347706-r0rs3ls1 124 78 VSV VSV NNP cord-347706-r0rs3ls1 124 79 - - HYPH cord-347706-r0rs3ls1 124 80 based base VBN cord-347706-r0rs3ls1 124 81 Severe severe JJ cord-347706-r0rs3ls1 124 82 acute acute JJ cord-347706-r0rs3ls1 124 83 respiratory respiratory JJ cord-347706-r0rs3ls1 124 84 syndrome syndrome NN cord-347706-r0rs3ls1 124 85 coronavirus coronavirus NN cord-347706-r0rs3ls1 124 86 infection infection NN cord-347706-r0rs3ls1 124 87 of of IN cord-347706-r0rs3ls1 124 88 golden golden JJ cord-347706-r0rs3ls1 124 89 Syrian syrian JJ cord-347706-r0rs3ls1 124 90 hamsters hamster NNS cord-347706-r0rs3ls1 124 91 SARS SARS NNP cord-347706-r0rs3ls1 124 92 virus virus NN cord-347706-r0rs3ls1 124 93 infection infection NN cord-347706-r0rs3ls1 124 94 of of IN cord-347706-r0rs3ls1 124 95 cats cat NNS cord-347706-r0rs3ls1 124 96 and and CC cord-347706-r0rs3ls1 124 97 ferrets ferret NNS cord-347706-r0rs3ls1 124 98 Human human JJ cord-347706-r0rs3ls1 124 99 monoclonal monoclonal JJ cord-347706-r0rs3ls1 124 100 antibody antibody NN cord-347706-r0rs3ls1 124 101 as as IN cord-347706-r0rs3ls1 124 102 prophylaxis prophylaxis NN cord-347706-r0rs3ls1 124 103 for for IN cord-347706-r0rs3ls1 124 104 SARS SARS NNP cord-347706-r0rs3ls1 124 105 coronavirus coronavirus NN cord-347706-r0rs3ls1 124 106 infection infection NN cord-347706-r0rs3ls1 124 107 in in IN cord-347706-r0rs3ls1 124 108 ferrets ferret NNS cord-347706-r0rs3ls1 124 109 Virology Virology NNP cord-347706-r0rs3ls1 124 110 : : : cord-347706-r0rs3ls1 124 111 SARS SARS NNP cord-347706-r0rs3ls1 124 112 virus virus NN cord-347706-r0rs3ls1 124 113 infection infection NN cord-347706-r0rs3ls1 124 114 of of IN cord-347706-r0rs3ls1 124 115 cats cat NNS cord-347706-r0rs3ls1 124 116 and and CC cord-347706-r0rs3ls1 124 117 ferrets ferret NNS cord-347706-r0rs3ls1 124 118 Syndrome syndrome NN cord-347706-r0rs3ls1 124 119 - - HYPH cord-347706-r0rs3ls1 124 120 associated associate VBN cord-347706-r0rs3ls1 124 121 coronavirus coronavirus NN cord-347706-r0rs3ls1 124 122 - - HYPH cord-347706-r0rs3ls1 124 123 neutralizing neutralize VBG cord-347706-r0rs3ls1 124 124 human human JJ cord-347706-r0rs3ls1 124 125 monoclonal monoclonal JJ cord-347706-r0rs3ls1 124 126 antibody antibody NN cord-347706-r0rs3ls1 124 127 reduces reduce VBZ cord-347706-r0rs3ls1 124 128 disease disease NN cord-347706-r0rs3ls1 124 129 severity severity NN cord-347706-r0rs3ls1 124 130 and and CC cord-347706-r0rs3ls1 124 131 virus virus NN cord-347706-r0rs3ls1 124 132 burden burden NN cord-347706-r0rs3ls1 124 133 in in IN cord-347706-r0rs3ls1 124 134 golden golden JJ cord-347706-r0rs3ls1 124 135 syrian syrian JJ cord-347706-r0rs3ls1 124 136 hamsters hamster NNS cord-347706-r0rs3ls1 125 1 Civets civet NNS cord-347706-r0rs3ls1 125 2 are be VBP cord-347706-r0rs3ls1 125 3 equally equally RB cord-347706-r0rs3ls1 125 4 susceptible susceptible JJ cord-347706-r0rs3ls1 125 5 to to IN cord-347706-r0rs3ls1 125 6 experimental experimental JJ cord-347706-r0rs3ls1 125 7 infection infection NN cord-347706-r0rs3ls1 125 8 by by IN cord-347706-r0rs3ls1 125 9 two two CD cord-347706-r0rs3ls1 125 10 different different JJ cord-347706-r0rs3ls1 125 11 severe severe JJ cord-347706-r0rs3ls1 125 12 acute acute JJ cord-347706-r0rs3ls1 125 13 respiratory respiratory JJ cord-347706-r0rs3ls1 125 14 syndrome syndrome NN cord-347706-r0rs3ls1 125 15 coronavirus coronavirus NN cord-347706-r0rs3ls1 125 16 isolates isolate VBZ cord-347706-r0rs3ls1 125 17 Isolation isolation NN cord-347706-r0rs3ls1 125 18 and and CC cord-347706-r0rs3ls1 125 19 characterization characterization NN cord-347706-r0rs3ls1 125 20 of of IN cord-347706-r0rs3ls1 125 21 viruses virus NNS cord-347706-r0rs3ls1 125 22 related relate VBN cord-347706-r0rs3ls1 125 23 to to IN cord-347706-r0rs3ls1 125 24 the the DT cord-347706-r0rs3ls1 125 25 SARS SARS NNP cord-347706-r0rs3ls1 125 26 coronavirus coronavirus NN cord-347706-r0rs3ls1 125 27 from from IN cord-347706-r0rs3ls1 125 28 animals animal NNS cord-347706-r0rs3ls1 125 29 in in IN cord-347706-r0rs3ls1 125 30 Southern Southern NNP cord-347706-r0rs3ls1 125 31 China China NNP cord-347706-r0rs3ls1 125 32 Macaque Macaque NNP cord-347706-r0rs3ls1 125 33 model model NN cord-347706-r0rs3ls1 125 34 for for IN cord-347706-r0rs3ls1 125 35 severe severe JJ cord-347706-r0rs3ls1 125 36 acute acute JJ cord-347706-r0rs3ls1 125 37 respiratory respiratory JJ cord-347706-r0rs3ls1 125 38 syndrome syndrome NN cord-347706-r0rs3ls1 125 39 Replication replication NN cord-347706-r0rs3ls1 125 40 of of IN cord-347706-r0rs3ls1 125 41 SARS SARS NNP cord-347706-r0rs3ls1 125 42 coronavirus coronavirus NN cord-347706-r0rs3ls1 125 43 administered administer VBN cord-347706-r0rs3ls1 125 44 into into IN cord-347706-r0rs3ls1 125 45 the the DT cord-347706-r0rs3ls1 125 46 respiratory respiratory JJ cord-347706-r0rs3ls1 125 47 tract tract NN cord-347706-r0rs3ls1 125 48 of of IN cord-347706-r0rs3ls1 125 49 African African NNP cord-347706-r0rs3ls1 125 50 Green Green NNP cord-347706-r0rs3ls1 125 51 , , , cord-347706-r0rs3ls1 125 52 rhesus rhesu NNS cord-347706-r0rs3ls1 125 53 and and CC cord-347706-r0rs3ls1 125 54 cynomolgus cynomolgus JJ cord-347706-r0rs3ls1 125 55 monkeys monkey NNS cord-347706-r0rs3ls1 126 1 Aetiology aetiology NN cord-347706-r0rs3ls1 126 2 : : : cord-347706-r0rs3ls1 127 1 Koch Koch NNP cord-347706-r0rs3ls1 127 2 's 's POS cord-347706-r0rs3ls1 127 3 postulates postulate NNS cord-347706-r0rs3ls1 127 4 fulfilled fulfil VBD cord-347706-r0rs3ls1 127 5 for for IN cord-347706-r0rs3ls1 127 6 SARS SARS NNP cord-347706-r0rs3ls1 127 7 virus virus NN cord-347706-r0rs3ls1 127 8 Newly newly RB cord-347706-r0rs3ls1 127 9 discovered discover VBD cord-347706-r0rs3ls1 127 10 coronavirus coronavirus NN cord-347706-r0rs3ls1 127 11 as as IN cord-347706-r0rs3ls1 127 12 the the DT cord-347706-r0rs3ls1 127 13 primary primary JJ cord-347706-r0rs3ls1 127 14 cause cause NN cord-347706-r0rs3ls1 127 15 of of IN cord-347706-r0rs3ls1 127 16 severe severe JJ cord-347706-r0rs3ls1 127 17 acute acute JJ cord-347706-r0rs3ls1 127 18 respiratory respiratory JJ cord-347706-r0rs3ls1 127 19 syndrome syndrome NN cord-347706-r0rs3ls1 128 1 Pegylated pegylate VBN cord-347706-r0rs3ls1 129 1 interferon interferon NN cord-347706-r0rs3ls1 129 2 - - HYPH cord-347706-r0rs3ls1 129 3 alpha alpha NN cord-347706-r0rs3ls1 129 4 protects protect VBZ cord-347706-r0rs3ls1 129 5 type type NN cord-347706-r0rs3ls1 129 6 1 1 CD cord-347706-r0rs3ls1 129 7 pneumocytes pneumocyte NNS cord-347706-r0rs3ls1 129 8 against against IN cord-347706-r0rs3ls1 129 9 SARS SARS NNP cord-347706-r0rs3ls1 129 10 coronavirus coronavirus NN cord-347706-r0rs3ls1 129 11 infection infection NN cord-347706-r0rs3ls1 129 12 in in IN cord-347706-r0rs3ls1 129 13 macaques macaque NNS cord-347706-r0rs3ls1 130 1 An an DT cord-347706-r0rs3ls1 130 2 animal animal NN cord-347706-r0rs3ls1 130 3 model model NN cord-347706-r0rs3ls1 130 4 of of IN cord-347706-r0rs3ls1 130 5 SARS SARS NNP cord-347706-r0rs3ls1 130 6 produced produce VBN cord-347706-r0rs3ls1 130 7 by by IN cord-347706-r0rs3ls1 130 8 infection infection NN cord-347706-r0rs3ls1 130 9 of of IN cord-347706-r0rs3ls1 130 10 Macaca Macaca NNP cord-347706-r0rs3ls1 130 11 mulatta mulatta NN cord-347706-r0rs3ls1 130 12 with with IN cord-347706-r0rs3ls1 130 13 SARS SARS NNP cord-347706-r0rs3ls1 130 14 coronavirus coronavirus NN cord-347706-r0rs3ls1 130 15 Pneumonitis Pneumonitis NNP cord-347706-r0rs3ls1 130 16 and and CC cord-347706-r0rs3ls1 130 17 multi multi JJ cord-347706-r0rs3ls1 130 18 - - JJ cord-347706-r0rs3ls1 130 19 organ organ JJ cord-347706-r0rs3ls1 130 20 system system NN cord-347706-r0rs3ls1 130 21 disease disease NN cord-347706-r0rs3ls1 130 22 in in IN cord-347706-r0rs3ls1 130 23 common common JJ cord-347706-r0rs3ls1 130 24 marmosets marmoset NNS cord-347706-r0rs3ls1 131 1 ( ( -LRB- cord-347706-r0rs3ls1 131 2 Callithrix Callithrix NNP cord-347706-r0rs3ls1 131 3 jacchus jacchus NNP cord-347706-r0rs3ls1 131 4 ) ) -RRB- cord-347706-r0rs3ls1 131 5 infected infect VBN cord-347706-r0rs3ls1 131 6 with with IN cord-347706-r0rs3ls1 131 7 the the DT cord-347706-r0rs3ls1 131 8 severe severe JJ cord-347706-r0rs3ls1 131 9 acute acute JJ cord-347706-r0rs3ls1 131 10 respiratory respiratory JJ cord-347706-r0rs3ls1 131 11 syndrome syndrome NN cord-347706-r0rs3ls1 131 12 - - HYPH cord-347706-r0rs3ls1 131 13 associated associate VBN cord-347706-r0rs3ls1 131 14 coronavirus coronavirus NN