id	sid	tid	token	lemma	pos
cord-307860-iqk1yiw4	1	1	key	key	NN
cord-307860-iqk1yiw4	1	2	:	:	:
cord-307860-iqk1yiw4	1	3	cord-307860-iqk1yiw4	cord-307860-iqk1yiw4	NNP
cord-307860-iqk1yiw4	1	4	authors	author	NNS
cord-307860-iqk1yiw4	1	5	:	:	:
cord-307860-iqk1yiw4	1	6	Ionescu	Ionescu	NNP
cord-307860-iqk1yiw4	1	7	,	,	,
cord-307860-iqk1yiw4	1	8	Mihaela	Mihaela	NNP
cord-307860-iqk1yiw4	1	9	Ileana	Ileana	NNP
cord-307860-iqk1yiw4	2	1	title	title	NN
cord-307860-iqk1yiw4	2	2	:	:	:
cord-307860-iqk1yiw4	3	1	An	an	DT
cord-307860-iqk1yiw4	3	2	Overview	Overview	NNP
cord-307860-iqk1yiw4	3	3	of	of	IN
cord-307860-iqk1yiw4	3	4	the	the	DT
cord-307860-iqk1yiw4	3	5	Crystallized	Crystallized	NNP
cord-307860-iqk1yiw4	3	6	Structures	Structures	NNPS
cord-307860-iqk1yiw4	3	7	of	of	IN
cord-307860-iqk1yiw4	3	8	the	the	DT
cord-307860-iqk1yiw4	3	9	SARS	SARS	NNP
cord-307860-iqk1yiw4	3	10	-	-	HYPH
cord-307860-iqk1yiw4	3	11	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	3	12	date	date	NN
cord-307860-iqk1yiw4	3	13	:	:	:
cord-307860-iqk1yiw4	3	14	2020	2020	CD
cord-307860-iqk1yiw4	3	15	-	-	SYM
cord-307860-iqk1yiw4	3	16	10	10	CD
cord-307860-iqk1yiw4	3	17	-	-	SYM
cord-307860-iqk1yiw4	3	18	24	24	CD
cord-307860-iqk1yiw4	3	19	journal	journal	NN
cord-307860-iqk1yiw4	3	20	:	:	:
cord-307860-iqk1yiw4	3	21	Protein	Protein	NNP
cord-307860-iqk1yiw4	3	22	J	J	NNP
cord-307860-iqk1yiw4	3	23	DOI	DOI	NNP
cord-307860-iqk1yiw4	3	24	:	:	:
cord-307860-iqk1yiw4	4	1	10.1007	10.1007	CD
cord-307860-iqk1yiw4	4	2	/	/	SYM
cord-307860-iqk1yiw4	4	3	s10930	s10930	NNP
cord-307860-iqk1yiw4	4	4	-	-	HYPH
cord-307860-iqk1yiw4	4	5	020	020	CD
cord-307860-iqk1yiw4	4	6	-	-	HYPH
cord-307860-iqk1yiw4	4	7	09933-w	09933-w	ADD
cord-307860-iqk1yiw4	5	1	sha	sha	NNP
cord-307860-iqk1yiw4	5	2	:	:	:
cord-307860-iqk1yiw4	5	3	406196058436499e28e4d4ec266cf567e23910ab	406196058436499e28e4d4ec266cf567e23910ab	CD
cord-307860-iqk1yiw4	5	4	doc_id	doc_id	CD
cord-307860-iqk1yiw4	5	5	:	:	:
cord-307860-iqk1yiw4	5	6	307860	307860	CD
cord-307860-iqk1yiw4	5	7	cord_uid	cord_uid	NNS
cord-307860-iqk1yiw4	5	8	:	:	:
cord-307860-iqk1yiw4	6	1	iqk1yiw4	iqk1yiw4	NNP
cord-307860-iqk1yiw4	7	1	Many	many	JJ
cord-307860-iqk1yiw4	7	2	research	research	NN
cord-307860-iqk1yiw4	7	3	teams	team	NNS
cord-307860-iqk1yiw4	7	4	all	all	RB
cord-307860-iqk1yiw4	7	5	over	over	IN
cord-307860-iqk1yiw4	7	6	the	the	DT
cord-307860-iqk1yiw4	7	7	world	world	NN
cord-307860-iqk1yiw4	7	8	focus	focus	VBP
cord-307860-iqk1yiw4	7	9	their	-PRON-	PRP$
cord-307860-iqk1yiw4	7	10	research	research	NN
cord-307860-iqk1yiw4	7	11	on	on	IN
cord-307860-iqk1yiw4	7	12	the	the	DT
cord-307860-iqk1yiw4	7	13	SARS	SARS	NNP
cord-307860-iqk1yiw4	7	14	-	-	HYPH
cord-307860-iqk1yiw4	7	15	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	7	16	,	,	,
cord-307860-iqk1yiw4	7	17	the	the	DT
cord-307860-iqk1yiw4	7	18	new	new	JJ
cord-307860-iqk1yiw4	7	19	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	7	20	that	that	WDT
cord-307860-iqk1yiw4	7	21	causes	cause	VBZ
cord-307860-iqk1yiw4	7	22	the	the	DT
cord-307860-iqk1yiw4	7	23	so	so	RB
cord-307860-iqk1yiw4	7	24	-	-	HYPH
cord-307860-iqk1yiw4	7	25	called	call	VBN
cord-307860-iqk1yiw4	7	26	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	7	27	disease	disease	NN
cord-307860-iqk1yiw4	7	28	.	.	.
cord-307860-iqk1yiw4	8	1	Most	Most	JJS
cord-307860-iqk1yiw4	8	2	of	of	IN
cord-307860-iqk1yiw4	8	3	the	the	DT
cord-307860-iqk1yiw4	8	4	studies	study	NNS
cord-307860-iqk1yiw4	8	5	identify	identify	VBP
cord-307860-iqk1yiw4	8	6	the	the	DT
cord-307860-iqk1yiw4	8	7	main	main	JJ
cord-307860-iqk1yiw4	8	8	protease	protease	NN
cord-307860-iqk1yiw4	8	9	or	or	CC
cord-307860-iqk1yiw4	8	10	3C	3c	NN
cord-307860-iqk1yiw4	8	11	-	-	HYPH
cord-307860-iqk1yiw4	8	12	like	like	JJ
cord-307860-iqk1yiw4	8	13	protease	protease	NN
cord-307860-iqk1yiw4	8	14	(	(	-LRB-
cord-307860-iqk1yiw4	8	15	M(pro)/3CL(pro	M(pro)/3CL(pro	NNP
cord-307860-iqk1yiw4	8	16	)	)	-RRB-
cord-307860-iqk1yiw4	8	17	)	)	-RRB-
cord-307860-iqk1yiw4	8	18	as	as	IN
cord-307860-iqk1yiw4	8	19	a	a	DT
cord-307860-iqk1yiw4	8	20	valid	valid	JJ
cord-307860-iqk1yiw4	8	21	target	target	NN
cord-307860-iqk1yiw4	8	22	for	for	IN
cord-307860-iqk1yiw4	8	23	large	large	JJ
cord-307860-iqk1yiw4	8	24	-	-	HYPH
cord-307860-iqk1yiw4	8	25	spectrum	spectrum	NN
cord-307860-iqk1yiw4	8	26	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	8	27	.	.	.
cord-307860-iqk1yiw4	9	1	Also	also	RB
cord-307860-iqk1yiw4	9	2	,	,	,
cord-307860-iqk1yiw4	9	3	the	the	DT
cord-307860-iqk1yiw4	9	4	interaction	interaction	NN
cord-307860-iqk1yiw4	9	5	of	of	IN
cord-307860-iqk1yiw4	9	6	the	the	DT
cord-307860-iqk1yiw4	9	7	human	human	JJ
cord-307860-iqk1yiw4	9	8	receptor	receptor	NN
cord-307860-iqk1yiw4	9	9	angiotensin	angiotensin	NN
cord-307860-iqk1yiw4	9	10	-	-	HYPH
cord-307860-iqk1yiw4	9	11	converting	convert	VBG
cord-307860-iqk1yiw4	9	12	enzyme	enzyme	NN
cord-307860-iqk1yiw4	9	13	2	2	CD
cord-307860-iqk1yiw4	9	14	(	(	-LRB-
cord-307860-iqk1yiw4	9	15	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	9	16	)	)	-RRB-
cord-307860-iqk1yiw4	9	17	with	with	IN
cord-307860-iqk1yiw4	9	18	the	the	DT
cord-307860-iqk1yiw4	9	19	viral	viral	JJ
cord-307860-iqk1yiw4	9	20	surface	surface	NN
cord-307860-iqk1yiw4	9	21	glycoprotein	glycoprotein	NN
cord-307860-iqk1yiw4	9	22	(	(	-LRB-
cord-307860-iqk1yiw4	9	23	S	s	NN
cord-307860-iqk1yiw4	9	24	)	)	-RRB-
cord-307860-iqk1yiw4	9	25	is	be	VBZ
cord-307860-iqk1yiw4	9	26	studied	study	VBN
cord-307860-iqk1yiw4	9	27	in	in	IN
cord-307860-iqk1yiw4	9	28	depth	depth	NN
cord-307860-iqk1yiw4	9	29	.	.	.
cord-307860-iqk1yiw4	10	1	Structural	structural	JJ
cord-307860-iqk1yiw4	10	2	studies	study	NNS
cord-307860-iqk1yiw4	10	3	tried	try	VBD
cord-307860-iqk1yiw4	10	4	to	to	TO
cord-307860-iqk1yiw4	10	5	identify	identify	VB
cord-307860-iqk1yiw4	10	6	the	the	DT
cord-307860-iqk1yiw4	10	7	residues	residue	NNS
cord-307860-iqk1yiw4	10	8	responsible	responsible	JJ
cord-307860-iqk1yiw4	10	9	for	for	IN
cord-307860-iqk1yiw4	10	10	enhancement	enhancement	NN
cord-307860-iqk1yiw4	10	11	/	/	SYM
cord-307860-iqk1yiw4	10	12	weaken	weaken	VBP
cord-307860-iqk1yiw4	10	13	virus	virus	NN
cord-307860-iqk1yiw4	10	14	-	-	:
cord-307860-iqk1yiw4	10	15	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	10	16	interactions	interaction	NNS
cord-307860-iqk1yiw4	10	17	or	or	CC
cord-307860-iqk1yiw4	10	18	the	the	DT
cord-307860-iqk1yiw4	10	19	cross	cross	NN
cord-307860-iqk1yiw4	10	20	-	-	NN
cord-307860-iqk1yiw4	10	21	reactivity	reactivity	NN
cord-307860-iqk1yiw4	10	22	of	of	IN
cord-307860-iqk1yiw4	10	23	the	the	DT
cord-307860-iqk1yiw4	10	24	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	10	25	antibodies	antibody	NNS
cord-307860-iqk1yiw4	10	26	.	.	.
cord-307860-iqk1yiw4	11	1	Although	although	IN
cord-307860-iqk1yiw4	11	2	the	the	DT
cord-307860-iqk1yiw4	11	3	understanding	understanding	NN
cord-307860-iqk1yiw4	11	4	of	of	IN
cord-307860-iqk1yiw4	11	5	the	the	DT
cord-307860-iqk1yiw4	11	6	immune	immune	JJ
cord-307860-iqk1yiw4	11	7	system	system	NN
cord-307860-iqk1yiw4	11	8	and	and	CC
cord-307860-iqk1yiw4	11	9	the	the	DT
cord-307860-iqk1yiw4	11	10	hyper	hyper	JJ
cord-307860-iqk1yiw4	11	11	-	-	JJ
cord-307860-iqk1yiw4	11	12	inflammatory	inflammatory	JJ
cord-307860-iqk1yiw4	11	13	process	process	NN
cord-307860-iqk1yiw4	11	14	in	in	IN
cord-307860-iqk1yiw4	11	15	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	11	16	are	be	VBP
cord-307860-iqk1yiw4	11	17	crucial	crucial	JJ
cord-307860-iqk1yiw4	11	18	for	for	IN
cord-307860-iqk1yiw4	11	19	managing	manage	VBG
cord-307860-iqk1yiw4	11	20	the	the	DT
cord-307860-iqk1yiw4	11	21	immediate	immediate	JJ
cord-307860-iqk1yiw4	11	22	and	and	CC
cord-307860-iqk1yiw4	11	23	the	the	DT
cord-307860-iqk1yiw4	11	24	long	long	JJ
cord-307860-iqk1yiw4	11	25	-	-	HYPH
cord-307860-iqk1yiw4	11	26	term	term	NN
cord-307860-iqk1yiw4	11	27	consequences	consequence	NNS
cord-307860-iqk1yiw4	11	28	of	of	IN
cord-307860-iqk1yiw4	11	29	the	the	DT
cord-307860-iqk1yiw4	11	30	disease	disease	NN
cord-307860-iqk1yiw4	11	31	,	,	,
cord-307860-iqk1yiw4	11	32	not	not	RB
cord-307860-iqk1yiw4	11	33	many	many	JJ
cord-307860-iqk1yiw4	11	34	X	x	NN
cord-307860-iqk1yiw4	11	35	-	-	NN
cord-307860-iqk1yiw4	11	36	ray	ray	NN
cord-307860-iqk1yiw4	11	37	/	/	SYM
cord-307860-iqk1yiw4	11	38	NMR	nmr	NN
cord-307860-iqk1yiw4	11	39	/	/	SYM
cord-307860-iqk1yiw4	11	40	cryo	cryo	NN
cord-307860-iqk1yiw4	11	41	-	-	HYPH
cord-307860-iqk1yiw4	11	42	EM	em	NN
cord-307860-iqk1yiw4	11	43	crystals	crystal	NNS
cord-307860-iqk1yiw4	11	44	are	be	VBP
cord-307860-iqk1yiw4	11	45	available	available	JJ
cord-307860-iqk1yiw4	11	46	.	.	.
cord-307860-iqk1yiw4	12	1	In	in	IN
cord-307860-iqk1yiw4	12	2	addition	addition	NN
cord-307860-iqk1yiw4	12	3	to	to	IN
cord-307860-iqk1yiw4	12	4	3CL(pro	3cl(pro	CD
cord-307860-iqk1yiw4	12	5	)	)	-RRB-
cord-307860-iqk1yiw4	12	6	,	,	,
cord-307860-iqk1yiw4	12	7	the	the	DT
cord-307860-iqk1yiw4	12	8	crystal	crystal	NN
cord-307860-iqk1yiw4	12	9	structures	structure	NNS
cord-307860-iqk1yiw4	12	10	of	of	IN
cord-307860-iqk1yiw4	12	11	other	other	JJ
cord-307860-iqk1yiw4	12	12	nonstructural	nonstructural	JJ
cord-307860-iqk1yiw4	12	13	proteins	protein	NNS
cord-307860-iqk1yiw4	12	14	offer	offer	VBP
cord-307860-iqk1yiw4	12	15	valuable	valuable	JJ
cord-307860-iqk1yiw4	12	16	information	information	NN
cord-307860-iqk1yiw4	12	17	for	for	IN
cord-307860-iqk1yiw4	12	18	elucidating	elucidate	VBG
cord-307860-iqk1yiw4	12	19	some	some	DT
cord-307860-iqk1yiw4	12	20	aspects	aspect	NNS
cord-307860-iqk1yiw4	12	21	of	of	IN
cord-307860-iqk1yiw4	12	22	the	the	DT
cord-307860-iqk1yiw4	12	23	SARS	SARS	NNP
cord-307860-iqk1yiw4	12	24	-	-	HYPH
cord-307860-iqk1yiw4	12	25	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	12	26	infection	infection	NN
cord-307860-iqk1yiw4	12	27	.	.	.
cord-307860-iqk1yiw4	13	1	Thus	thus	RB
cord-307860-iqk1yiw4	13	2	,	,	,
cord-307860-iqk1yiw4	13	3	the	the	DT
cord-307860-iqk1yiw4	13	4	structural	structural	JJ
cord-307860-iqk1yiw4	13	5	analysis	analysis	NN
cord-307860-iqk1yiw4	13	6	of	of	IN
cord-307860-iqk1yiw4	13	7	the	the	DT
cord-307860-iqk1yiw4	13	8	SARS	SARS	NNP
cord-307860-iqk1yiw4	13	9	-	-	HYPH
cord-307860-iqk1yiw4	13	10	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	13	11	is	be	VBZ
cord-307860-iqk1yiw4	13	12	currently	currently	RB
cord-307860-iqk1yiw4	13	13	mainly	mainly	RB
cord-307860-iqk1yiw4	13	14	focused	focus	VBN
cord-307860-iqk1yiw4	13	15	on	on	IN
cord-307860-iqk1yiw4	13	16	three	three	CD
cord-307860-iqk1yiw4	13	17	directions	direction	NNS
cord-307860-iqk1yiw4	13	18	—	—	:
cord-307860-iqk1yiw4	13	19	finding	find	VBG
cord-307860-iqk1yiw4	13	20	M(pro)/3CL(pro	M(pro)/3CL(pro	NNP
cord-307860-iqk1yiw4	13	21	)	)	-RRB-
cord-307860-iqk1yiw4	14	1	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	14	2	,	,	,
cord-307860-iqk1yiw4	14	3	the	the	DT
cord-307860-iqk1yiw4	14	4	virus	virus	NN
cord-307860-iqk1yiw4	14	5	-	-	HYPH
cord-307860-iqk1yiw4	14	6	host	host	NN
cord-307860-iqk1yiw4	14	7	cell	cell	NN
cord-307860-iqk1yiw4	14	8	invasion	invasion	NN
cord-307860-iqk1yiw4	14	9	,	,	,
cord-307860-iqk1yiw4	14	10	and	and	CC
cord-307860-iqk1yiw4	14	11	the	the	DT
cord-307860-iqk1yiw4	14	12	virus	virus	NN
cord-307860-iqk1yiw4	14	13	-	-	HYPH
cord-307860-iqk1yiw4	14	14	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	14	15	antibody	antibody	NN
cord-307860-iqk1yiw4	14	16	interaction	interaction	NN
cord-307860-iqk1yiw4	14	17	.	.	.
cord-307860-iqk1yiw4	15	1	ELECTRONIC	ELECTRONIC	NNP
cord-307860-iqk1yiw4	15	2	SUPPLEMENTARY	supplementary	JJ
cord-307860-iqk1yiw4	15	3	MATERIAL	material	NN
cord-307860-iqk1yiw4	15	4	:	:	:
cord-307860-iqk1yiw4	16	1	The	the	DT
cord-307860-iqk1yiw4	16	2	online	online	JJ
cord-307860-iqk1yiw4	16	3	version	version	NN
cord-307860-iqk1yiw4	16	4	of	of	IN
cord-307860-iqk1yiw4	16	5	this	this	DT
cord-307860-iqk1yiw4	16	6	article	article	NN
cord-307860-iqk1yiw4	16	7	(	(	-LRB-
cord-307860-iqk1yiw4	16	8	10.1007	10.1007	CD
cord-307860-iqk1yiw4	16	9	/	/	SYM
cord-307860-iqk1yiw4	16	10	s10930	s10930	NNP
cord-307860-iqk1yiw4	16	11	-	-	HYPH
cord-307860-iqk1yiw4	16	12	020	020	CD
cord-307860-iqk1yiw4	16	13	-	-	HYPH
cord-307860-iqk1yiw4	16	14	09933-w	09933-w	ADD
cord-307860-iqk1yiw4	16	15	)	)	-RRB-
cord-307860-iqk1yiw4	16	16	contains	contain	VBZ
cord-307860-iqk1yiw4	16	17	supplementary	supplementary	JJ
cord-307860-iqk1yiw4	16	18	material	material	NN
cord-307860-iqk1yiw4	16	19	,	,	,
cord-307860-iqk1yiw4	16	20	which	which	WDT
cord-307860-iqk1yiw4	16	21	is	be	VBZ
cord-307860-iqk1yiw4	16	22	available	available	JJ
cord-307860-iqk1yiw4	16	23	to	to	IN
cord-307860-iqk1yiw4	16	24	authorized	authorize	VBN
cord-307860-iqk1yiw4	16	25	users	user	NNS
cord-307860-iqk1yiw4	16	26	.	.	.
cord-307860-iqk1yiw4	17	1	latest	late	JJS
cord-307860-iqk1yiw4	17	2	works	work	VBZ
cord-307860-iqk1yiw4	17	3	[	[	-LRB-
cord-307860-iqk1yiw4	17	4	6	6	CD
cord-307860-iqk1yiw4	17	5	,	,	,
cord-307860-iqk1yiw4	17	6	7	7	CD
cord-307860-iqk1yiw4	17	7	]	]	-RRB-
cord-307860-iqk1yiw4	17	8	.	.	.
cord-307860-iqk1yiw4	18	1	Much	much	JJ
cord-307860-iqk1yiw4	18	2	of	of	IN
cord-307860-iqk1yiw4	18	3	the	the	DT
cord-307860-iqk1yiw4	18	4	knowledge	knowledge	NN
cord-307860-iqk1yiw4	18	5	about	about	IN
cord-307860-iqk1yiw4	18	6	the	the	DT
cord-307860-iqk1yiw4	18	7	transmission	transmission	NN
cord-307860-iqk1yiw4	18	8	of	of	IN
cord-307860-iqk1yiw4	18	9	SARS	SARS	NNP
cord-307860-iqk1yiw4	18	10	-	-	HYPH
cord-307860-iqk1yiw4	18	11	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	18	12	has	have	VBZ
cord-307860-iqk1yiw4	18	13	gleaned	glean	VBN
cord-307860-iqk1yiw4	18	14	from	from	IN
cord-307860-iqk1yiw4	18	15	the	the	DT
cord-307860-iqk1yiw4	18	16	SARS	SARS	NNP
cord-307860-iqk1yiw4	18	17	-	-	HYPH
cord-307860-iqk1yiw4	18	18	CoV	CoV	NNP
cord-307860-iqk1yiw4	18	19	and	and	CC
cord-307860-iqk1yiw4	18	20	MERS	MERS	NNP
cord-307860-iqk1yiw4	18	21	-	-	HYPH
cord-307860-iqk1yiw4	18	22	CoV	CoV	NNP
cord-307860-iqk1yiw4	18	23	studies	study	NNS
cord-307860-iqk1yiw4	18	24	[	[	-LRB-
cord-307860-iqk1yiw4	18	25	5	5	CD
cord-307860-iqk1yiw4	18	26	,	,	,
cord-307860-iqk1yiw4	18	27	8	8	CD
cord-307860-iqk1yiw4	18	28	]	]	-RRB-
cord-307860-iqk1yiw4	18	29	.	.	.
cord-307860-iqk1yiw4	19	1	There	there	EX
cord-307860-iqk1yiw4	19	2	are	be	VBP
cord-307860-iqk1yiw4	19	3	some	some	DT
cord-307860-iqk1yiw4	19	4	notable	notable	JJ
cord-307860-iqk1yiw4	19	5	differences	difference	NNS
cord-307860-iqk1yiw4	19	6	between	between	IN
cord-307860-iqk1yiw4	19	7	tissue	tissue	NN
cord-307860-iqk1yiw4	19	8	tropism	tropism	NN
cord-307860-iqk1yiw4	19	9	of	of	IN
cord-307860-iqk1yiw4	19	10	the	the	DT
cord-307860-iqk1yiw4	19	11	HCoVs	hcovs	CD
cord-307860-iqk1yiw4	19	12	.	.	.
cord-307860-iqk1yiw4	20	1	Analysis	analysis	NN
cord-307860-iqk1yiw4	20	2	of	of	IN
cord-307860-iqk1yiw4	20	3	structural	structural	JJ
cord-307860-iqk1yiw4	20	4	similarities	similarity	NNS
cord-307860-iqk1yiw4	20	5	and	and	CC
cord-307860-iqk1yiw4	20	6	structural	structural	JJ
cord-307860-iqk1yiw4	20	7	differences	difference	NNS
cord-307860-iqk1yiw4	20	8	between	between	IN
cord-307860-iqk1yiw4	20	9	HCoVs	hcovs	CD
cord-307860-iqk1yiw4	20	10	species	specie	NNS
cord-307860-iqk1yiw4	20	11	could	could	MD
cord-307860-iqk1yiw4	20	12	advance	advance	VB
cord-307860-iqk1yiw4	20	13	the	the	DT
cord-307860-iqk1yiw4	20	14	understanding	understanding	NN
cord-307860-iqk1yiw4	20	15	of	of	IN
cord-307860-iqk1yiw4	20	16	SARS	SARS	NNP
cord-307860-iqk1yiw4	20	17	-	-	HYPH
cord-307860-iqk1yiw4	20	18	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	20	19	pathogenesis	pathogenesis	NN
cord-307860-iqk1yiw4	20	20	[	[	-LRB-
cord-307860-iqk1yiw4	20	21	8	8	CD
cord-307860-iqk1yiw4	20	22	]	]	-RRB-
cord-307860-iqk1yiw4	20	23	[	[	-LRB-
cord-307860-iqk1yiw4	20	24	9	9	CD
cord-307860-iqk1yiw4	20	25	]	]	-RRB-
cord-307860-iqk1yiw4	20	26	[	[	-LRB-
cord-307860-iqk1yiw4	20	27	10	10	CD
cord-307860-iqk1yiw4	20	28	]	]	-RRB-
cord-307860-iqk1yiw4	20	29	[	[	-LRB-
cord-307860-iqk1yiw4	20	30	11	11	CD
cord-307860-iqk1yiw4	20	31	]	]	-RRB-
cord-307860-iqk1yiw4	20	32	[	[	-LRB-
cord-307860-iqk1yiw4	20	33	12	12	CD
cord-307860-iqk1yiw4	20	34	]	]	-RRB-
cord-307860-iqk1yiw4	20	35	.	.	.
cord-307860-iqk1yiw4	21	1	The	the	DT
cord-307860-iqk1yiw4	21	2	review	review	NN
cord-307860-iqk1yiw4	21	3	aims	aim	VBZ
cord-307860-iqk1yiw4	21	4	to	to	TO
cord-307860-iqk1yiw4	21	5	collect	collect	VB
cord-307860-iqk1yiw4	21	6	and	and	CC
cord-307860-iqk1yiw4	21	7	synthesize	synthesize	VB
cord-307860-iqk1yiw4	21	8	the	the	DT
cord-307860-iqk1yiw4	21	9	X	x	NN
cord-307860-iqk1yiw4	21	10	-	-	NN
cord-307860-iqk1yiw4	21	11	ray/	ray/	NNP
cord-307860-iqk1yiw4	21	12	NMR	nmr	NN
cord-307860-iqk1yiw4	21	13	/	/	SYM
cord-307860-iqk1yiw4	21	14	cryo	cryo	NN
cord-307860-iqk1yiw4	21	15	-	-	HYPH
cord-307860-iqk1yiw4	21	16	EM	EM	NNP
cord-307860-iqk1yiw4	21	17	structures	structure	NNS
cord-307860-iqk1yiw4	21	18	of	of	IN
cord-307860-iqk1yiw4	22	1	the	the	DT
cord-307860-iqk1yiw4	22	2	SARS	SARS	NNP
cord-307860-iqk1yiw4	22	3	-	-	HYPH
cord-307860-iqk1yiw4	22	4	Cov-2	Cov-2	NNP
cord-307860-iqk1yiw4	22	5	deposited	deposit	VBN
cord-307860-iqk1yiw4	22	6	in	in	IN
cord-307860-iqk1yiw4	22	7	the	the	DT
cord-307860-iqk1yiw4	22	8	public	public	JJ
cord-307860-iqk1yiw4	22	9	database	database	NN
cord-307860-iqk1yiw4	22	10	Protein	Protein	NNP
cord-307860-iqk1yiw4	22	11	Data	Data	NNP
cord-307860-iqk1yiw4	22	12	Bank	Bank	NNP
cord-307860-iqk1yiw4	22	13	(	(	-LRB-
cord-307860-iqk1yiw4	22	14	PDB	PDB	NNP
cord-307860-iqk1yiw4	22	15	)	)	-RRB-
cord-307860-iqk1yiw4	23	1	(	(	-LRB-
cord-307860-iqk1yiw4	23	2	https	https	NNP
cord-307860-iqk1yiw4	23	3	:	:	:
cord-307860-iqk1yiw4	24	1	//www	//www	VBN
cord-307860-iqk1yiw4	24	2	.	.	.
cord-307860-iqk1yiw4	24	3	rcsb.org/pdb	rcsb.org/pdb	ADD
cord-307860-iqk1yiw4	24	4	)	)	-RRB-
cord-307860-iqk1yiw4	24	5	.	.	.
cord-307860-iqk1yiw4	25	1	Structures	structure	NNS
cord-307860-iqk1yiw4	25	2	retrieved	retrieve	VBD
cord-307860-iqk1yiw4	25	3	from	from	IN
cord-307860-iqk1yiw4	25	4	PDB	PDB	NNP
cord-307860-iqk1yiw4	25	5	(	(	-LRB-
cord-307860-iqk1yiw4	25	6	August	August	NNP
cord-307860-iqk1yiw4	25	7	12	12	CD
cord-307860-iqk1yiw4	25	8	,	,	,
cord-307860-iqk1yiw4	25	9	2020	2020	CD
cord-307860-iqk1yiw4	25	10	)	)	-RRB-
cord-307860-iqk1yiw4	25	11	were	be	VBD
cord-307860-iqk1yiw4	25	12	analyzed	analyze	VBN
cord-307860-iqk1yiw4	25	13	for	for	IN
cord-307860-iqk1yiw4	25	14	relevant	relevant	JJ
cord-307860-iqk1yiw4	25	15	information	information	NN
cord-307860-iqk1yiw4	25	16	on	on	IN
cord-307860-iqk1yiw4	25	17	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	25	18	infection	infection	NN
cord-307860-iqk1yiw4	25	19	,	,	,
cord-307860-iqk1yiw4	25	20	synthesis	synthesis	NN
cord-307860-iqk1yiw4	25	21	of	of	IN
cord-307860-iqk1yiw4	25	22	new	new	JJ
cord-307860-iqk1yiw4	25	23	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	25	24	,	,	,
cord-307860-iqk1yiw4	25	25	SARS	SARS	NNP
cord-307860-iqk1yiw4	25	26	-	-	HYPH
cord-307860-iqk1yiw4	25	27	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	25	28	interaction	interaction	NN
cord-307860-iqk1yiw4	25	29	with	with	IN
cord-307860-iqk1yiw4	25	30	host	host	NN
cord-307860-iqk1yiw4	25	31	receptors	receptor	NNS
cord-307860-iqk1yiw4	25	32	,	,	,
cord-307860-iqk1yiw4	25	33	and	and	CC
cord-307860-iqk1yiw4	25	34	the	the	DT
cord-307860-iqk1yiw4	25	35	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	25	36	antibodies	antibody	NNS
cord-307860-iqk1yiw4	25	37	interactions	interaction	NNS
cord-307860-iqk1yiw4	25	38	with	with	IN
cord-307860-iqk1yiw4	25	39	spike	spike	NN
cord-307860-iqk1yiw4	25	40	glycoprotein	glycoprotein	NN
cord-307860-iqk1yiw4	25	41	.	.	.
cord-307860-iqk1yiw4	26	1	In	in	IN
cord-307860-iqk1yiw4	26	2	this	this	DT
cord-307860-iqk1yiw4	26	3	review	review	NN
cord-307860-iqk1yiw4	26	4	,	,	,
cord-307860-iqk1yiw4	26	5	the	the	DT
cord-307860-iqk1yiw4	26	6	SARS	SARS	NNP
cord-307860-iqk1yiw4	26	7	-	-	HYPH
cord-307860-iqk1yiw4	26	8	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	26	9	related	related	JJ
cord-307860-iqk1yiw4	26	10	structures	structure	NNS
cord-307860-iqk1yiw4	26	11	published	publish	VBN
cord-307860-iqk1yiw4	26	12	in	in	IN
cord-307860-iqk1yiw4	26	13	peer	peer	NN
cord-307860-iqk1yiw4	26	14	-	-	HYPH
cord-307860-iqk1yiw4	26	15	reviewed	review	VBN
cord-307860-iqk1yiw4	26	16	papers	paper	NNS
cord-307860-iqk1yiw4	26	17	are	be	VBP
cord-307860-iqk1yiw4	26	18	analyzed	analyze	VBN
cord-307860-iqk1yiw4	26	19	in	in	IN
cord-307860-iqk1yiw4	26	20	depth	depth	NN
cord-307860-iqk1yiw4	26	21	.	.	.
cord-307860-iqk1yiw4	27	1	Very	very	RB
cord-307860-iqk1yiw4	27	2	often	often	RB
cord-307860-iqk1yiw4	27	3	the	the	DT
cord-307860-iqk1yiw4	27	4	authors	author	NNS
cord-307860-iqk1yiw4	27	5	add	add	VBP
cord-307860-iqk1yiw4	27	6	minor	minor	JJ
cord-307860-iqk1yiw4	27	7	/	/	SYM
cord-307860-iqk1yiw4	27	8	major	major	JJ
cord-307860-iqk1yiw4	27	9	revisions	revision	NNS
cord-307860-iqk1yiw4	27	10	of	of	IN
cord-307860-iqk1yiw4	27	11	the	the	DT
cord-307860-iqk1yiw4	27	12	coordinate	coordinate	JJ
cord-307860-iqk1yiw4	27	13	files	file	NNS
cord-307860-iqk1yiw4	27	14	after	after	IN
cord-307860-iqk1yiw4	27	15	the	the	DT
cord-307860-iqk1yiw4	27	16	PDB	PDB	NNP
cord-307860-iqk1yiw4	27	17	structure	structure	NN
cord-307860-iqk1yiw4	27	18	was	be	VBD
cord-307860-iqk1yiw4	27	19	submitted	submit	VBN
cord-307860-iqk1yiw4	27	20	in	in	IN
cord-307860-iqk1yiw4	27	21	the	the	DT
cord-307860-iqk1yiw4	27	22	PDB	PDB	NNP
cord-307860-iqk1yiw4	27	23	.	.	.
cord-307860-iqk1yiw4	28	1	An	an	DT
cord-307860-iqk1yiw4	28	2	association	association	NN
cord-307860-iqk1yiw4	28	3	of	of	IN
cord-307860-iqk1yiw4	28	4	scientists	scientist	NNS
cord-307860-iqk1yiw4	28	5	has	have	VBZ
cord-307860-iqk1yiw4	28	6	created	create	VBN
cord-307860-iqk1yiw4	28	7	a	a	DT
cord-307860-iqk1yiw4	28	8	public	public	JJ
cord-307860-iqk1yiw4	28	9	database	database	NN
cord-307860-iqk1yiw4	28	10	in	in	IN
cord-307860-iqk1yiw4	28	11	which	which	WDT
cord-307860-iqk1yiw4	28	12	CoVs	covs	JJ
cord-307860-iqk1yiw4	28	13	structures	structure	NNS
cord-307860-iqk1yiw4	28	14	are	be	VBP
cord-307860-iqk1yiw4	28	15	systematically	systematically	RB
cord-307860-iqk1yiw4	28	16	validated	validate	VBN
cord-307860-iqk1yiw4	28	17	(	(	-LRB-
cord-307860-iqk1yiw4	28	18	https	https	NNP
cord-307860-iqk1yiw4	28	19	:	:	:
cord-307860-iqk1yiw4	28	20	//covid	//covid	.
cord-307860-iqk1yiw4	29	1	-19.biore	-19.biore	:
cord-307860-iqk1yiw4	29	2	produ	produ	NNP
cord-307860-iqk1yiw4	29	3	cibil	cibil	NNP
cord-307860-iqk1yiw4	29	4	ity.org/	ity.org/	NNP
cord-307860-iqk1yiw4	29	5	)	)	-RRB-
cord-307860-iqk1yiw4	30	1	[	[	-LRB-
cord-307860-iqk1yiw4	30	2	13	13	CD
cord-307860-iqk1yiw4	30	3	]	]	-RRB-
cord-307860-iqk1yiw4	30	4	.	.	.
cord-307860-iqk1yiw4	31	1	The	the	DT
cord-307860-iqk1yiw4	31	2	aim	aim	NN
cord-307860-iqk1yiw4	31	3	of	of	IN
cord-307860-iqk1yiw4	31	4	this	this	DT
cord-307860-iqk1yiw4	31	5	review	review	NN
cord-307860-iqk1yiw4	31	6	is	be	VBZ
cord-307860-iqk1yiw4	31	7	to	to	TO
cord-307860-iqk1yiw4	31	8	provide	provide	VB
cord-307860-iqk1yiw4	31	9	an	an	DT
cord-307860-iqk1yiw4	31	10	analysis	analysis	NN
cord-307860-iqk1yiw4	31	11	of	of	IN
cord-307860-iqk1yiw4	31	12	the	the	DT
cord-307860-iqk1yiw4	31	13	SARS	SARS	NNP
cord-307860-iqk1yiw4	31	14	-	-	HYPH
cord-307860-iqk1yiw4	31	15	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	31	16	structures	structure	NNS
cord-307860-iqk1yiw4	31	17	deposited	deposit	VBN
cord-307860-iqk1yiw4	31	18	in	in	IN
cord-307860-iqk1yiw4	31	19	the	the	DT
cord-307860-iqk1yiw4	31	20	PDB	PDB	NNP
cord-307860-iqk1yiw4	31	21	.	.	.
cord-307860-iqk1yiw4	32	1	Every	every	DT
cord-307860-iqk1yiw4	32	2	Wednesday	Wednesday	NNP
cord-307860-iqk1yiw4	32	3	,	,	,
cord-307860-iqk1yiw4	32	4	the	the	DT
cord-307860-iqk1yiw4	32	5	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	32	6	/	/	SYM
cord-307860-iqk1yiw4	32	7	SARS	SARS	NNP
cord-307860-iqk1yiw4	32	8	-	-	HYPH
cord-307860-iqk1yiw4	32	9	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	32	10	Resources	Resources	NNPS
cord-307860-iqk1yiw4	32	11	announce	announce	VBP
cord-307860-iqk1yiw4	32	12	the	the	DT
cord-307860-iqk1yiw4	32	13	new	new	JJ
cord-307860-iqk1yiw4	32	14	PDB	PDB	NNP
cord-307860-iqk1yiw4	32	15	structures	structure	NNS
cord-307860-iqk1yiw4	32	16	(	(	-LRB-
cord-307860-iqk1yiw4	32	17	https	https	NN
cord-307860-iqk1yiw4	32	18	:	:	:
cord-307860-iqk1yiw4	32	19	//www.rcsb.org/	//www.rcsb.org/	NNP
cord-307860-iqk1yiw4	32	20	)	)	-RRB-
cord-307860-iqk1yiw4	32	21	.	.	.
cord-307860-iqk1yiw4	33	1	The	the	DT
cord-307860-iqk1yiw4	33	2	rapid	rapid	JJ
cord-307860-iqk1yiw4	33	3	accumulation	accumulation	NN
cord-307860-iqk1yiw4	33	4	of	of	IN
cord-307860-iqk1yiw4	33	5	the	the	DT
cord-307860-iqk1yiw4	33	6	X	x	NN
cord-307860-iqk1yiw4	33	7	-	-	NN
cord-307860-iqk1yiw4	33	8	ray	ray	NN
cord-307860-iqk1yiw4	33	9	/	/	SYM
cord-307860-iqk1yiw4	33	10	NMR	nmr	NN
cord-307860-iqk1yiw4	33	11	/	/	SYM
cord-307860-iqk1yiw4	33	12	cryo	cryo	NN
cord-307860-iqk1yiw4	33	13	-	-	HYPH
cord-307860-iqk1yiw4	33	14	EM	EM	NNP
cord-307860-iqk1yiw4	33	15	structures	structure	NNS
cord-307860-iqk1yiw4	33	16	of	of	IN
cord-307860-iqk1yiw4	33	17	the	the	DT
cord-307860-iqk1yiw4	33	18	SARS	SARS	NNP
cord-307860-iqk1yiw4	33	19	-	-	HYPH
cord-307860-iqk1yiw4	33	20	Cov-2	Cov-2	NNP
cord-307860-iqk1yiw4	33	21	in	in	IN
cord-307860-iqk1yiw4	33	22	the	the	DT
cord-307860-iqk1yiw4	33	23	Protein	Protein	NNP
cord-307860-iqk1yiw4	33	24	Data	Data	NNP
cord-307860-iqk1yiw4	33	25	Base	Base	NNP
cord-307860-iqk1yiw4	33	26	(	(	-LRB-
cord-307860-iqk1yiw4	33	27	PDB	PDB	NNP
cord-307860-iqk1yiw4	33	28	)	)	-RRB-
cord-307860-iqk1yiw4	33	29	needs	need	VBZ
cord-307860-iqk1yiw4	33	30	an	an	DT
cord-307860-iqk1yiw4	33	31	objective	objective	JJ
cord-307860-iqk1yiw4	33	32	selection	selection	NN
cord-307860-iqk1yiw4	33	33	analysis	analysis	NN
cord-307860-iqk1yiw4	33	34	of	of	IN
cord-307860-iqk1yiw4	33	35	these	these	DT
cord-307860-iqk1yiw4	33	36	crystal	crystal	NN
cord-307860-iqk1yiw4	33	37	structures	structure	NNS
cord-307860-iqk1yiw4	33	38	for	for	IN
cord-307860-iqk1yiw4	33	39	further	further	JJ
cord-307860-iqk1yiw4	33	40	research	research	NN
cord-307860-iqk1yiw4	33	41	.	.	.
cord-307860-iqk1yiw4	34	1	The	the	DT
cord-307860-iqk1yiw4	34	2	COVID-19	covid-19	NN
cord-307860-iqk1yiw4	34	3	is	be	VBZ
cord-307860-iqk1yiw4	34	4	an	an	DT
cord-307860-iqk1yiw4	34	5	ongoing	ongoing	JJ
cord-307860-iqk1yiw4	34	6	pandemic	pandemic	NN
cord-307860-iqk1yiw4	34	7	and	and	CC
cord-307860-iqk1yiw4	34	8	the	the	DT
cord-307860-iqk1yiw4	34	9	virus	virus	NN
cord-307860-iqk1yiw4	34	10	undergoes	undergo	VBZ
cord-307860-iqk1yiw4	34	11	mutations	mutation	NNS
cord-307860-iqk1yiw4	34	12	reflected	reflect	VBN
cord-307860-iqk1yiw4	34	13	in	in	IN
cord-307860-iqk1yiw4	34	14	differences	difference	NNS
cord-307860-iqk1yiw4	34	15	of	of	IN
cord-307860-iqk1yiw4	34	16	the	the	DT
cord-307860-iqk1yiw4	34	17	crystal	crystal	NN
cord-307860-iqk1yiw4	34	18	structures	structure	NNS
cord-307860-iqk1yiw4	34	19	.	.	.
cord-307860-iqk1yiw4	35	1	There	there	EX
cord-307860-iqk1yiw4	35	2	are	be	VBP
cord-307860-iqk1yiw4	35	3	many	many	JJ
cord-307860-iqk1yiw4	35	4	crystal	crystal	NN
cord-307860-iqk1yiw4	35	5	structures	structure	NNS
cord-307860-iqk1yiw4	35	6	of	of	IN
cord-307860-iqk1yiw4	35	7	the	the	DT
cord-307860-iqk1yiw4	35	8	SARS	SARS	NNP
cord-307860-iqk1yiw4	35	9	-	-	HYPH
cord-307860-iqk1yiw4	35	10	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	35	11	spike	spike	NN
cord-307860-iqk1yiw4	35	12	(	(	-LRB-
cord-307860-iqk1yiw4	35	13	S	s	NN
cord-307860-iqk1yiw4	35	14	)	)	-RRB-
cord-307860-iqk1yiw4	35	15	co	co	NNS
cord-307860-iqk1yiw4	35	16	-	-	VBN
cord-307860-iqk1yiw4	35	17	crystallized	crystallize	VBN
cord-307860-iqk1yiw4	35	18	with	with	IN
cord-307860-iqk1yiw4	35	19	antibodies	antibody	NNS
cord-307860-iqk1yiw4	35	20	that	that	WDT
cord-307860-iqk1yiw4	35	21	further	further	RB
cord-307860-iqk1yiw4	35	22	advance	advance	VBP
cord-307860-iqk1yiw4	35	23	the	the	DT
cord-307860-iqk1yiw4	35	24	understanding	understanding	NN
cord-307860-iqk1yiw4	35	25	of	of	IN
cord-307860-iqk1yiw4	35	26	the	the	DT
cord-307860-iqk1yiw4	35	27	immunogenicity	immunogenicity	NN
cord-307860-iqk1yiw4	35	28	of	of	IN
cord-307860-iqk1yiw4	35	29	the	the	DT
cord-307860-iqk1yiw4	35	30	S	S	NNP
cord-307860-iqk1yiw4	35	31	[	[	-LRB-
cord-307860-iqk1yiw4	35	32	14	14	CD
cord-307860-iqk1yiw4	35	33	]	]	-RRB-
cord-307860-iqk1yiw4	35	34	[	[	-LRB-
cord-307860-iqk1yiw4	35	35	15	15	CD
cord-307860-iqk1yiw4	35	36	]	]	-RRB-
cord-307860-iqk1yiw4	35	37	[	[	-LRB-
cord-307860-iqk1yiw4	35	38	16	16	CD
cord-307860-iqk1yiw4	35	39	]	]	-RRB-
cord-307860-iqk1yiw4	35	40	[	[	-LRB-
cord-307860-iqk1yiw4	35	41	17	17	CD
cord-307860-iqk1yiw4	35	42	]	]	-RRB-
cord-307860-iqk1yiw4	35	43	[	[	-LRB-
cord-307860-iqk1yiw4	35	44	18	18	CD
cord-307860-iqk1yiw4	35	45	]	]	-RRB-
cord-307860-iqk1yiw4	35	46	[	[	-LRB-
cord-307860-iqk1yiw4	35	47	19	19	CD
cord-307860-iqk1yiw4	35	48	]	]	-RRB-
cord-307860-iqk1yiw4	35	49	[	[	-LRB-
cord-307860-iqk1yiw4	35	50	20	20	CD
cord-307860-iqk1yiw4	35	51	]	]	-RRB-
cord-307860-iqk1yiw4	35	52	[	[	-LRB-
cord-307860-iqk1yiw4	35	53	21	21	CD
cord-307860-iqk1yiw4	35	54	]	]	-RRB-
cord-307860-iqk1yiw4	35	55	[	[	-LRB-
cord-307860-iqk1yiw4	35	56	22	22	CD
cord-307860-iqk1yiw4	35	57	]	]	-RRB-
cord-307860-iqk1yiw4	35	58	[	[	-LRB-
cord-307860-iqk1yiw4	35	59	23	23	CD
cord-307860-iqk1yiw4	35	60	]	]	-RRB-
cord-307860-iqk1yiw4	36	1	[	[	-LRB-
cord-307860-iqk1yiw4	36	2	24	24	CD
cord-307860-iqk1yiw4	36	3	]	]	-RRB-
cord-307860-iqk1yiw4	36	4	[	[	-LRB-
cord-307860-iqk1yiw4	36	5	25	25	CD
cord-307860-iqk1yiw4	36	6	]	]	-RRB-
cord-307860-iqk1yiw4	36	7	.	.	.
cord-307860-iqk1yiw4	37	1	Also	also	RB
cord-307860-iqk1yiw4	37	2	,	,	,
cord-307860-iqk1yiw4	37	3	there	there	EX
cord-307860-iqk1yiw4	37	4	is	be	VBZ
cord-307860-iqk1yiw4	37	5	an	an	DT
cord-307860-iqk1yiw4	37	6	intense	intense	JJ
cord-307860-iqk1yiw4	37	7	work	work	NN
cord-307860-iqk1yiw4	37	8	on	on	IN
cord-307860-iqk1yiw4	37	9	designing	design	VBG
cord-307860-iqk1yiw4	37	10	effective	effective	JJ
cord-307860-iqk1yiw4	37	11	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	37	12	.	.	.
cord-307860-iqk1yiw4	38	1	There	there	EX
cord-307860-iqk1yiw4	38	2	are	be	VBP
cord-307860-iqk1yiw4	38	3	many	many	JJ
cord-307860-iqk1yiw4	38	4	compounds	compound	NNS
cord-307860-iqk1yiw4	38	5	mainly	mainly	RB
cord-307860-iqk1yiw4	38	6	co	co	VBD
cord-307860-iqk1yiw4	38	7	-	-	VBD
cord-307860-iqk1yiw4	38	8	crystallized	crystallize	VBN
cord-307860-iqk1yiw4	38	9	with	with	IN
cord-307860-iqk1yiw4	38	10	the	the	DT
cord-307860-iqk1yiw4	38	11	viral	viral	JJ
cord-307860-iqk1yiw4	38	12	main	main	JJ
cord-307860-iqk1yiw4	38	13	protease	protease	NN
cord-307860-iqk1yiw4	38	14	(	(	-LRB-
cord-307860-iqk1yiw4	38	15	3CL	3cl	NN
cord-307860-iqk1yiw4	38	16	-	-	HYPH
cord-307860-iqk1yiw4	38	17	protease	protease	NN
cord-307860-iqk1yiw4	38	18	)	)	-RRB-
cord-307860-iqk1yiw4	38	19	.	.	.
cord-307860-iqk1yiw4	39	1	The	the	DT
cord-307860-iqk1yiw4	39	2	subgroup	subgroup	NN
cord-307860-iqk1yiw4	39	3	analysis	analysis	NN
cord-307860-iqk1yiw4	39	4	of	of	IN
cord-307860-iqk1yiw4	39	5	structural	structural	JJ
cord-307860-iqk1yiw4	39	6	and	and	CC
cord-307860-iqk1yiw4	39	7	non	non	JJ
cord-307860-iqk1yiw4	39	8	-	-	JJ
cord-307860-iqk1yiw4	39	9	structural	structural	JJ
cord-307860-iqk1yiw4	39	10	protein	protein	NN
cord-307860-iqk1yiw4	39	11	(	(	-LRB-
cord-307860-iqk1yiw4	39	12	nsp	nsp	NNP
cord-307860-iqk1yiw4	39	13	)	)	-RRB-
cord-307860-iqk1yiw4	39	14	of	of	IN
cord-307860-iqk1yiw4	39	15	the	the	DT
cord-307860-iqk1yiw4	39	16	SARS	SARS	NNP
cord-307860-iqk1yiw4	39	17	-	-	HYPH
cord-307860-iqk1yiw4	39	18	Cov-2	Cov-2	NNP
cord-307860-iqk1yiw4	39	19	and	and	CC
cord-307860-iqk1yiw4	39	20	other	other	JJ
cord-307860-iqk1yiw4	39	21	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	39	22	includes	include	VBZ
cord-307860-iqk1yiw4	39	23	the	the	DT
cord-307860-iqk1yiw4	39	24	multiple	multiple	JJ
cord-307860-iqk1yiw4	39	25	sequence	sequence	NN
cord-307860-iqk1yiw4	39	26	alignment	alignment	NN
cord-307860-iqk1yiw4	39	27	.	.	.
cord-307860-iqk1yiw4	40	1	The	the	DT
cord-307860-iqk1yiw4	40	2	X	x	NN
cord-307860-iqk1yiw4	40	3	-	-	NN
cord-307860-iqk1yiw4	40	4	ray	ray	NN
cord-307860-iqk1yiw4	40	5	/	/	SYM
cord-307860-iqk1yiw4	40	6	NMR	nmr	NN
cord-307860-iqk1yiw4	40	7	/	/	SYM
cord-307860-iqk1yiw4	40	8	cryo	cryo	NN
cord-307860-iqk1yiw4	40	9	-	-	HYPH
cord-307860-iqk1yiw4	40	10	EM	EM	NNP
cord-307860-iqk1yiw4	40	11	structures	structure	NNS
cord-307860-iqk1yiw4	40	12	of	of	IN
cord-307860-iqk1yiw4	40	13	the	the	DT
cord-307860-iqk1yiw4	40	14	SARS	SARS	NNP
cord-307860-iqk1yiw4	40	15	-	-	HYPH
cord-307860-iqk1yiw4	40	16	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	40	17	were	be	VBD
cord-307860-iqk1yiw4	40	18	retrieved	retrieve	VBN
cord-307860-iqk1yiw4	40	19	by	by	IN
cord-307860-iqk1yiw4	40	20	searching	search	VBG
cord-307860-iqk1yiw4	40	21	"	"	``
cord-307860-iqk1yiw4	40	22	SARS	SARS	NNP
cord-307860-iqk1yiw4	40	23	-	-	HYPH
cord-307860-iqk1yiw4	40	24	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	40	25	"	"	''
cord-307860-iqk1yiw4	40	26	in	in	IN
cord-307860-iqk1yiw4	40	27	PDB	PDB	NNP
cord-307860-iqk1yiw4	40	28	(	(	-LRB-
cord-307860-iqk1yiw4	40	29	https	https	NNP
cord-307860-iqk1yiw4	40	30	:	:	:
cord-307860-iqk1yiw4	40	31	//www.rcsb.org	//www.rcsb.org	.
cord-307860-iqk1yiw4	40	32	/	/	SYM
cord-307860-iqk1yiw4	40	33	pdb	pdb	NN
cord-307860-iqk1yiw4	40	34	)	)	-RRB-
cord-307860-iqk1yiw4	40	35	.	.	.
cord-307860-iqk1yiw4	41	1	Inclusion	inclusion	NN
cord-307860-iqk1yiw4	41	2	criteria	criterion	NNS
cord-307860-iqk1yiw4	41	3	:	:	:
cord-307860-iqk1yiw4	42	1	The	the	DT
cord-307860-iqk1yiw4	42	2	present	present	JJ
cord-307860-iqk1yiw4	42	3	review	review	NN
cord-307860-iqk1yiw4	42	4	narrows	narrow	VBZ
cord-307860-iqk1yiw4	42	5	the	the	DT
cord-307860-iqk1yiw4	42	6	analysis	analysis	NN
cord-307860-iqk1yiw4	42	7	of	of	IN
cord-307860-iqk1yiw4	42	8	the	the	DT
cord-307860-iqk1yiw4	42	9	SARS	SARS	NNP
cord-307860-iqk1yiw4	42	10	-	-	HYPH
cord-307860-iqk1yiw4	42	11	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	42	12	crystal	crystal	NN
cord-307860-iqk1yiw4	42	13	structures	structure	NNS
cord-307860-iqk1yiw4	42	14	deposited	deposit	VBN
cord-307860-iqk1yiw4	42	15	in	in	IN
cord-307860-iqk1yiw4	42	16	the	the	DT
cord-307860-iqk1yiw4	42	17	PDB	PDB	NNP
cord-307860-iqk1yiw4	42	18	only	only	RB
cord-307860-iqk1yiw4	42	19	for	for	IN
cord-307860-iqk1yiw4	42	20	the	the	DT
cord-307860-iqk1yiw4	42	21	crystal	crystal	NN
cord-307860-iqk1yiw4	42	22	structures	structure	NNS
cord-307860-iqk1yiw4	42	23	published	publish	VBN
cord-307860-iqk1yiw4	42	24	in	in	IN
cord-307860-iqk1yiw4	42	25	peerreviewed	peerreviewed	JJ
cord-307860-iqk1yiw4	42	26	journals	journal	NNS
cord-307860-iqk1yiw4	42	27	(	(	-LRB-
cord-307860-iqk1yiw4	42	28	August	August	NNP
cord-307860-iqk1yiw4	42	29	12	12	CD
cord-307860-iqk1yiw4	42	30	,	,	,
cord-307860-iqk1yiw4	42	31	2020	2020	CD
cord-307860-iqk1yiw4	42	32	)	)	-RRB-
cord-307860-iqk1yiw4	42	33	.	.	.
cord-307860-iqk1yiw4	43	1	The	the	DT
cord-307860-iqk1yiw4	43	2	further	further	JJ
cord-307860-iqk1yiw4	43	3	analysis	analysis	NN
cord-307860-iqk1yiw4	43	4	of	of	IN
cord-307860-iqk1yiw4	43	5	some	some	DT
cord-307860-iqk1yiw4	43	6	important	important	JJ
cord-307860-iqk1yiw4	43	7	characteristics	characteristic	NNS
cord-307860-iqk1yiw4	43	8	of	of	IN
cord-307860-iqk1yiw4	43	9	the	the	DT
cord-307860-iqk1yiw4	43	10	SARS	SARS	NNP
cord-307860-iqk1yiw4	43	11	-	-	HYPH
cord-307860-iqk1yiw4	43	12	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	43	13	needs	need	VBZ
cord-307860-iqk1yiw4	43	14	the	the	DT
cord-307860-iqk1yiw4	43	15	inclusions	inclusion	NNS
cord-307860-iqk1yiw4	43	16	of	of	IN
cord-307860-iqk1yiw4	43	17	other	other	JJ
cord-307860-iqk1yiw4	43	18	five	five	CD
cord-307860-iqk1yiw4	43	19	crystal	crystal	NN
cord-307860-iqk1yiw4	43	20	structures	structure	NNS
cord-307860-iqk1yiw4	43	21	(	(	-LRB-
cord-307860-iqk1yiw4	43	22	Fig	Fig	NNP
cord-307860-iqk1yiw4	43	23	.	.	.
cord-307860-iqk1yiw4	43	24	1	1	CD
cord-307860-iqk1yiw4	43	25	)	)	-RRB-
cord-307860-iqk1yiw4	43	26	.	.	.
cord-307860-iqk1yiw4	44	1	The	the	DT
cord-307860-iqk1yiw4	44	2	structures	structure	NNS
cord-307860-iqk1yiw4	44	3	were	be	VBD
cord-307860-iqk1yiw4	44	4	checked	check	VBN
cord-307860-iqk1yiw4	44	5	in	in	IN
cord-307860-iqk1yiw4	44	6	the	the	DT
cord-307860-iqk1yiw4	44	7	Validated	Validated	NNP
cord-307860-iqk1yiw4	44	8	SARS	SARS	NNP
cord-307860-iqk1yiw4	44	9	-	-	HYPH
cord-307860-iqk1yiw4	44	10	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	44	11	related	related	JJ
cord-307860-iqk1yiw4	44	12	structural	structural	JJ
cord-307860-iqk1yiw4	44	13	models	model	NNS
cord-307860-iqk1yiw4	44	14	of	of	IN
cord-307860-iqk1yiw4	44	15	potential	potential	JJ
cord-307860-iqk1yiw4	44	16	drug	drug	NN
cord-307860-iqk1yiw4	44	17	targets	target	NNS
cord-307860-iqk1yiw4	44	18	site	site	NN
cord-307860-iqk1yiw4	44	19	(	(	-LRB-
cord-307860-iqk1yiw4	44	20	https	https	NNP
cord-307860-iqk1yiw4	44	21	:	:	:
cord-307860-iqk1yiw4	44	22	//covid	//covid	.
cord-307860-iqk1yiw4	45	1	-19.biore	-19.biore	:
cord-307860-iqk1yiw4	45	2	produ	produ	NNP
cord-307860-iqk1yiw4	45	3	cibil	cibil	NNP
cord-307860-iqk1yiw4	45	4	ity.org/	ity.org/	NNP
cord-307860-iqk1yiw4	45	5	)	)	-RRB-
cord-307860-iqk1yiw4	46	1	[	[	-LRB-
cord-307860-iqk1yiw4	46	2	13	13	CD
cord-307860-iqk1yiw4	46	3	]	]	-RRB-
cord-307860-iqk1yiw4	46	4	.	.	.
cord-307860-iqk1yiw4	47	1	Exclusion	exclusion	NN
cord-307860-iqk1yiw4	47	2	criteria	criterion	NNS
cord-307860-iqk1yiw4	47	3	:	:	:
cord-307860-iqk1yiw4	48	1	The	the	DT
cord-307860-iqk1yiw4	48	2	PDB	PDB	NNP
cord-307860-iqk1yiw4	48	3	SARS	SARS	NNP
cord-307860-iqk1yiw4	48	4	-	-	HYPH
cord-307860-iqk1yiw4	48	5	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	48	6	related	related	JJ
cord-307860-iqk1yiw4	48	7	crystal	crystal	NN
cord-307860-iqk1yiw4	48	8	structures	structure	NNS
cord-307860-iqk1yiw4	48	9	non	non	JJ
cord-307860-iqk1yiw4	48	10	-	-	JJ
cord-307860-iqk1yiw4	48	11	published	publish	VBN
cord-307860-iqk1yiw4	48	12	in	in	IN
cord-307860-iqk1yiw4	48	13	peer	peer	NN
cord-307860-iqk1yiw4	48	14	-	-	HYPH
cord-307860-iqk1yiw4	48	15	reviewed	review	VBN
cord-307860-iqk1yiw4	48	16	journals	journal	NNS
cord-307860-iqk1yiw4	48	17	.	.	.
cord-307860-iqk1yiw4	49	1	The	the	DT
cord-307860-iqk1yiw4	49	2	structures	structure	NNS
cord-307860-iqk1yiw4	49	3	were	be	VBD
cord-307860-iqk1yiw4	49	4	visualize	visualize	VB
cord-307860-iqk1yiw4	49	5	and	and	CC
cord-307860-iqk1yiw4	49	6	analyzed	analyze	VBN
cord-307860-iqk1yiw4	49	7	on	on	IN
cord-307860-iqk1yiw4	49	8	Dassault	Dassault	NNP
cord-307860-iqk1yiw4	49	9	Systèmes	Systèmes	NNP
cord-307860-iqk1yiw4	49	10	BIOVA	BIOVA	NNP
cord-307860-iqk1yiw4	49	11	program	program	NN
cord-307860-iqk1yiw4	49	12	-	-	HYPH
cord-307860-iqk1yiw4	49	13	Discovery	Discovery	NNP
cord-307860-iqk1yiw4	49	14	Studio	Studio	NNP
cord-307860-iqk1yiw4	49	15	Modeling	Modeling	NNP
cord-307860-iqk1yiw4	49	16	Environment	Environment	NNP
cord-307860-iqk1yiw4	49	17	,	,	,
cord-307860-iqk1yiw4	49	18	Release	release	NN
cord-307860-iqk1yiw4	49	19	2017	2017	CD
cord-307860-iqk1yiw4	49	20	,	,	,
cord-307860-iqk1yiw4	49	21	San	San	NNP
cord-307860-iqk1yiw4	49	22	Diego	Diego	NNP
cord-307860-iqk1yiw4	49	23	:	:	:
cord-307860-iqk1yiw4	49	24	Dassault	Dassault	NNP
cord-307860-iqk1yiw4	49	25	Systèmes	Systèmes	NNP
cord-307860-iqk1yiw4	49	26	,	,	,
cord-307860-iqk1yiw4	49	27	2016	2016	CD
cord-307860-iqk1yiw4	49	28	(	(	-LRB-
cord-307860-iqk1yiw4	49	29	https	https	NN
cord-307860-iqk1yiw4	49	30	:	:	:
cord-307860-iqk1yiw4	50	1	//accel	//accel	.
cord-307860-iqk1yiw4	51	1	rys.com	rys.com	ADD
cord-307860-iqk1yiw4	51	2	)	)	-RRB-
cord-307860-iqk1yiw4	51	3	.	.	.
cord-307860-iqk1yiw4	52	1	[	[	-LRB-
cord-307860-iqk1yiw4	52	2	26	26	CD
cord-307860-iqk1yiw4	52	3	]	]	-RRB-
cord-307860-iqk1yiw4	52	4	[	[	-LRB-
cord-307860-iqk1yiw4	52	5	27	27	CD
cord-307860-iqk1yiw4	52	6	]	]	-RRB-
cord-307860-iqk1yiw4	52	7	[	[	-LRB-
cord-307860-iqk1yiw4	52	8	28	28	CD
cord-307860-iqk1yiw4	52	9	]	]	-RRB-
cord-307860-iqk1yiw4	52	10	.	.	.
cord-307860-iqk1yiw4	53	1	The	the	DT
cord-307860-iqk1yiw4	53	2	search	search	NN
cord-307860-iqk1yiw4	53	3	of	of	IN
cord-307860-iqk1yiw4	53	4	"	"	``
cord-307860-iqk1yiw4	53	5	SARS	SARS	NNP
cord-307860-iqk1yiw4	53	6	-	-	HYPH
cord-307860-iqk1yiw4	53	7	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	53	8	"	"	''
cord-307860-iqk1yiw4	53	9	in	in	IN
cord-307860-iqk1yiw4	53	10	PDB	PDB	NNP
cord-307860-iqk1yiw4	53	11	retrieved	retrieve	VBD
cord-307860-iqk1yiw4	53	12	337	337	CD
cord-307860-iqk1yiw4	53	13	entries	entry	NNS
cord-307860-iqk1yiw4	53	14	(	(	-LRB-
cord-307860-iqk1yiw4	53	15	August	August	NNP
cord-307860-iqk1yiw4	53	16	12	12	CD
cord-307860-iqk1yiw4	53	17	,	,	,
cord-307860-iqk1yiw4	53	18	2020	2020	CD
cord-307860-iqk1yiw4	53	19	)	)	-RRB-
cord-307860-iqk1yiw4	53	20	(	(	-LRB-
cord-307860-iqk1yiw4	53	21	Table	Table	NNP
cord-307860-iqk1yiw4	53	22	S1	S1	NNP
cord-307860-iqk1yiw4	53	23	)	)	-RRB-
cord-307860-iqk1yiw4	53	24	.	.	.
cord-307860-iqk1yiw4	54	1	Among	among	IN
cord-307860-iqk1yiw4	54	2	them	-PRON-	PRP
cord-307860-iqk1yiw4	54	3	,	,	,
cord-307860-iqk1yiw4	54	4	only	only	RB
cord-307860-iqk1yiw4	54	5	65	65	CD
cord-307860-iqk1yiw4	54	6	of	of	IN
cord-307860-iqk1yiw4	54	7	2	2	CD
cord-307860-iqk1yiw4	54	8	X	x	NN
cord-307860-iqk1yiw4	54	9	-	-	NN
cord-307860-iqk1yiw4	54	10	ray	ray	NN
cord-307860-iqk1yiw4	54	11	/	/	SYM
cord-307860-iqk1yiw4	54	12	NMR	nmr	NN
cord-307860-iqk1yiw4	54	13	/	/	SYM
cord-307860-iqk1yiw4	54	14	cryo	cryo	NN
cord-307860-iqk1yiw4	54	15	-	-	HYPH
cord-307860-iqk1yiw4	54	16	EM	EM	NNP
cord-307860-iqk1yiw4	54	17	structures	structure	NNS
cord-307860-iqk1yiw4	54	18	are	be	VBP
cord-307860-iqk1yiw4	54	19	published	publish	VBN
cord-307860-iqk1yiw4	54	20	until	until	IN
cord-307860-iqk1yiw4	54	21	now	now	RB
cord-307860-iqk1yiw4	54	22	-	-	HYPH
cord-307860-iqk1yiw4	54	23	PDB	PDB	NNP
cord-307860-iqk1yiw4	54	24	ID(s	ID(s	NNP
cord-307860-iqk1yiw4	54	25	)	)	-RRB-
cord-307860-iqk1yiw4	54	26	6LXT	6lxt	XX
cord-307860-iqk1yiw4	54	27	,	,	,
cord-307860-iqk1yiw4	54	28	6VYB	6vyb	CD
cord-307860-iqk1yiw4	54	29	,	,	,
cord-307860-iqk1yiw4	54	30	6VXX	6vxx	CD
cord-307860-iqk1yiw4	54	31	,	,	,
cord-307860-iqk1yiw4	54	32	7BTF	7BTF	NNP
cord-307860-iqk1yiw4	54	33	,	,	,
cord-307860-iqk1yiw4	54	34	6M71	6m71	CD
cord-307860-iqk1yiw4	54	35	,	,	,
cord-307860-iqk1yiw4	54	36	6M0J	6m0j	CD
cord-307860-iqk1yiw4	54	37	,	,	,
cord-307860-iqk1yiw4	54	38	6M3	6m3	CD
cord-307860-iqk1yiw4	54	39	M	M	NNP
cord-307860-iqk1yiw4	54	40	,	,	,
cord-307860-iqk1yiw4	54	41	6W01	6w01	CD
cord-307860-iqk1yiw4	54	42	,	,	,
cord-307860-iqk1yiw4	54	43	6VWW	6vww	CD
cord-307860-iqk1yiw4	54	44	,	,	,
cord-307860-iqk1yiw4	54	45	6VSB	6VSB	NNP
cord-307860-iqk1yiw4	54	46	,	,	,
cord-307860-iqk1yiw4	54	47	6LZG	6lzg	CD
cord-307860-iqk1yiw4	54	48	,	,	,
cord-307860-iqk1yiw4	54	49	7BV1	7bv1	CD
cord-307860-iqk1yiw4	54	50	,	,	,
cord-307860-iqk1yiw4	54	51	7BV2	7bv2	CD
cord-307860-iqk1yiw4	54	52	,	,	,
cord-307860-iqk1yiw4	54	53	6YYT	6yyt	CD
cord-307860-iqk1yiw4	54	54	,	,	,
cord-307860-iqk1yiw4	54	55	6M17	6m17	CD
cord-307860-iqk1yiw4	54	56	,	,	,
cord-307860-iqk1yiw4	54	57	6VW1,6XR8	6vw1,6xr8	CD
cord-307860-iqk1yiw4	54	58	,	,	,
cord-307860-iqk1yiw4	54	59	6XRA	6xra	CD
cord-307860-iqk1yiw4	54	60	,	,	,
cord-307860-iqk1yiw4	54	61	6LU7	6lu7	CD
cord-307860-iqk1yiw4	54	62	,	,	,
cord-307860-iqk1yiw4	54	63	7BQY	7bqy	CD
cord-307860-iqk1yiw4	54	64	,	,	,
cord-307860-iqk1yiw4	54	65	6LZE	6lze	CD
cord-307860-iqk1yiw4	54	66	,	,	,
cord-307860-iqk1yiw4	54	67	6M0	6m0	CD
cord-307860-iqk1yiw4	54	68	K	K	NNP
cord-307860-iqk1yiw4	54	69	,	,	,
cord-307860-iqk1yiw4	54	70	7BUY	7BUY	NNP
cord-307860-iqk1yiw4	54	71	,	,	,
cord-307860-iqk1yiw4	54	72	6Y2E	6y2e	CD
cord-307860-iqk1yiw4	54	73	,	,	,
cord-307860-iqk1yiw4	54	74	6Y2	6y2	CD
cord-307860-iqk1yiw4	54	75	G	g	NN
cord-307860-iqk1yiw4	54	76	,	,	,
cord-307860-iqk1yiw4	54	77	6Y2F	6y2f	CD
cord-307860-iqk1yiw4	54	78	,	,	,
cord-307860-iqk1yiw4	54	79	6W41	6w41	CD
cord-307860-iqk1yiw4	54	80	,	,	,
cord-307860-iqk1yiw4	54	81	6YOR	6yor	CD
cord-307860-iqk1yiw4	54	82	,	,	,
cord-307860-iqk1yiw4	54	83	7BZ5	7bz5	CD
cord-307860-iqk1yiw4	54	84	,	,	,
cord-307860-iqk1yiw4	54	85	7C01	7c01	CD
cord-307860-iqk1yiw4	54	86	,	,	,
cord-307860-iqk1yiw4	54	87	7BWJ	7BWJ	NNP
cord-307860-iqk1yiw4	54	88	,	,	,
cord-307860-iqk1yiw4	54	89	7BYR	7BYR	NNP
cord-307860-iqk1yiw4	54	90	,	,	,
cord-307860-iqk1yiw4	54	91	6XCM	6xcm	UH
cord-307860-iqk1yiw4	54	92	,	,	,
cord-307860-iqk1yiw4	54	93	6XCN	6XCN	NNP
cord-307860-iqk1yiw4	54	94	,	,	,
cord-307860-iqk1yiw4	54	95	6XCA	6XCA	NNP
cord-307860-iqk1yiw4	54	96	,	,	,
cord-307860-iqk1yiw4	54	97	7C2L	7c2l	CD
cord-307860-iqk1yiw4	54	98	,	,	,
cord-307860-iqk1yiw4	54	99	7BZF	7BZF	NNP
cord-307860-iqk1yiw4	54	100	,	,	,
cord-307860-iqk1yiw4	54	101	7C2	7c2	CD
cord-307860-iqk1yiw4	54	102	K	K	NNP
cord-307860-iqk1yiw4	54	103	,	,	,
cord-307860-iqk1yiw4	54	104	6Z97	6z97	CD
cord-307860-iqk1yiw4	54	105	,	,	,
cord-307860-iqk1yiw4	54	106	6ZLW	6zlw	CD
cord-307860-iqk1yiw4	54	107	,	,	,
cord-307860-iqk1yiw4	54	108	6ZM7	6zm7	CD
cord-307860-iqk1yiw4	54	109	,	,	,
cord-307860-iqk1yiw4	54	110	6ZN5	6zn5	CD
cord-307860-iqk1yiw4	54	111	,	,	,
cord-307860-iqk1yiw4	54	112	6ZON	6zon	CD
cord-307860-iqk1yiw4	54	113	,	,	,
cord-307860-iqk1yiw4	54	114	6ZP4	6zp4	CD
cord-307860-iqk1yiw4	54	115	,	,	,
cord-307860-iqk1yiw4	54	116	6XDG	6XDG	NNP
cord-307860-iqk1yiw4	54	117	,	,	,
cord-307860-iqk1yiw4	54	118	6WQF	6wqf	JJ
cord-307860-iqk1yiw4	54	119	,	,	,
cord-307860-iqk1yiw4	54	120	7BW4	7bw4	CD
cord-307860-iqk1yiw4	54	121	,	,	,
cord-307860-iqk1yiw4	54	122	7CAH	7CAH	NNP
cord-307860-iqk1yiw4	54	123	,	,	,
cord-307860-iqk1yiw4	54	124	6XEY	6XEY	NNP
cord-307860-iqk1yiw4	54	125	,	,	,
cord-307860-iqk1yiw4	54	126	6ZOX	6zox	CD
cord-307860-iqk1yiw4	54	127	,	,	,
cord-307860-iqk1yiw4	54	128	6ZOZ	6zoz	CD
cord-307860-iqk1yiw4	54	129	,	,	,
cord-307860-iqk1yiw4	54	130	6ZOY	6zoy	UH
cord-307860-iqk1yiw4	54	131	,	,	,
cord-307860-iqk1yiw4	54	132	6ZP0	6zp0	CD
cord-307860-iqk1yiw4	54	133	,	,	,
cord-307860-iqk1yiw4	54	134	6ZP1	6zp1	CD
cord-307860-iqk1yiw4	54	135	,	,	,
cord-307860-iqk1yiw4	54	136	6ZP2	6zp2	CD
cord-307860-iqk1yiw4	54	137	,	,	,
cord-307860-iqk1yiw4	54	138	6YVA	6yva	CD
cord-307860-iqk1yiw4	54	139	,	,	,
cord-307860-iqk1yiw4	54	140	6ZCZ	6ZCZ	NNP
cord-307860-iqk1yiw4	54	141	,	,	,
cord-307860-iqk1yiw4	54	142	6ZDH	6ZDH	NNP
cord-307860-iqk1yiw4	54	143	,	,	,
cord-307860-iqk1yiw4	54	144	6ZDG	6zdg	CD
cord-307860-iqk1yiw4	54	145	,	,	,
cord-307860-iqk1yiw4	54	146	6ZER	6ZER	NNP
cord-307860-iqk1yiw4	54	147	,	,	,
cord-307860-iqk1yiw4	54	148	6ZFO	6zfo	CD
cord-307860-iqk1yiw4	54	149	,	,	,
cord-307860-iqk1yiw4	54	150	6ZMI	6zmi	CD
cord-307860-iqk1yiw4	54	151	,	,	,
cord-307860-iqk1yiw4	54	152	6ZMO	6zmo	CD
cord-307860-iqk1yiw4	54	153	,	,	,
cord-307860-iqk1yiw4	54	154	6ZMT	6zmt	CD
cord-307860-iqk1yiw4	54	155	,	,	,
cord-307860-iqk1yiw4	54	156	and	and	CC
cord-307860-iqk1yiw4	54	157	6ZME	6zme	CD
cord-307860-iqk1yiw4	54	158	[	[	-LRB-
cord-307860-iqk1yiw4	54	159	14	14	CD
cord-307860-iqk1yiw4	54	160	]	]	-RRB-
cord-307860-iqk1yiw4	54	161	[	[	-LRB-
cord-307860-iqk1yiw4	54	162	15	15	CD
cord-307860-iqk1yiw4	54	163	]	]	-RRB-
cord-307860-iqk1yiw4	54	164	[	[	-LRB-
cord-307860-iqk1yiw4	54	165	16	16	CD
cord-307860-iqk1yiw4	54	166	]	]	-RRB-
cord-307860-iqk1yiw4	55	1	[	[	-LRB-
cord-307860-iqk1yiw4	55	2	17	17	CD
cord-307860-iqk1yiw4	55	3	]	]	-RRB-
cord-307860-iqk1yiw4	55	4	[	[	-LRB-
cord-307860-iqk1yiw4	55	5	18	18	CD
cord-307860-iqk1yiw4	55	6	]	]	-RRB-
cord-307860-iqk1yiw4	55	7	[	[	-LRB-
cord-307860-iqk1yiw4	55	8	19	19	CD
cord-307860-iqk1yiw4	55	9	]	]	-RRB-
cord-307860-iqk1yiw4	56	1	[	[	-LRB-
cord-307860-iqk1yiw4	56	2	20	20	CD
cord-307860-iqk1yiw4	56	3	]	]	-RRB-
cord-307860-iqk1yiw4	56	4	[	[	-LRB-
cord-307860-iqk1yiw4	56	5	21	21	CD
cord-307860-iqk1yiw4	56	6	]	]	-RRB-
cord-307860-iqk1yiw4	57	1	[	[	-LRB-
cord-307860-iqk1yiw4	57	2	22	22	CD
cord-307860-iqk1yiw4	57	3	]	]	-RRB-
cord-307860-iqk1yiw4	57	4	[	[	-LRB-
cord-307860-iqk1yiw4	57	5	23	23	CD
cord-307860-iqk1yiw4	57	6	]	]	-RRB-
cord-307860-iqk1yiw4	58	1	[	[	-LRB-
cord-307860-iqk1yiw4	58	2	24	24	CD
cord-307860-iqk1yiw4	58	3	]	]	-RRB-
cord-307860-iqk1yiw4	58	4	[	[	-LRB-
cord-307860-iqk1yiw4	58	5	25	25	CD
cord-307860-iqk1yiw4	58	6	]	]	-RRB-
cord-307860-iqk1yiw4	58	7	.	.	.
cord-307860-iqk1yiw4	59	1	The	the	DT
cord-307860-iqk1yiw4	59	2	first	first	JJ
cord-307860-iqk1yiw4	59	3	X	x	NN
cord-307860-iqk1yiw4	59	4	-	-	NN
cord-307860-iqk1yiw4	59	5	ray	ray	NN
cord-307860-iqk1yiw4	59	6	structure	structure	NN
cord-307860-iqk1yiw4	59	7	found	find	VBD
cord-307860-iqk1yiw4	59	8	(	(	-LRB-
cord-307860-iqk1yiw4	59	9	PDB	PDB	NNP
cord-307860-iqk1yiw4	59	10	ID	ID	NNP
cord-307860-iqk1yiw4	59	11	6LU7	6lu7	CD
cord-307860-iqk1yiw4	59	12	)	)	-RRB-
cord-307860-iqk1yiw4	59	13	belongs	belong	VBZ
cord-307860-iqk1yiw4	59	14	to	to	IN
cord-307860-iqk1yiw4	59	15	the	the	DT
cord-307860-iqk1yiw4	59	16	nonstructural	nonstructural	JJ
cord-307860-iqk1yiw4	59	17	protein	protein	NNP
cord-307860-iqk1yiw4	59	18	5	5	CD
cord-307860-iqk1yiw4	59	19	(	(	-LRB-
cord-307860-iqk1yiw4	59	20	3C	3c	NN
cord-307860-iqk1yiw4	59	21	-	-	HYPH
cord-307860-iqk1yiw4	59	22	like	like	JJ
cord-307860-iqk1yiw4	59	23	protease	protease	NN
cord-307860-iqk1yiw4	59	24	)	)	-RRB-
cord-307860-iqk1yiw4	59	25	of	of	IN
cord-307860-iqk1yiw4	59	26	the	the	DT
cord-307860-iqk1yiw4	59	27	SARS	SARS	NNP
cord-307860-iqk1yiw4	59	28	-	-	HYPH
cord-307860-iqk1yiw4	59	29	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	59	30	in	in	IN
cord-307860-iqk1yiw4	59	31	complex	complex	NN
cord-307860-iqk1yiw4	59	32	with	with	IN
cord-307860-iqk1yiw4	59	33	the	the	DT
cord-307860-iqk1yiw4	59	34	Michael	Michael	NNP
cord-307860-iqk1yiw4	59	35	acceptor	acceptor	NN
cord-307860-iqk1yiw4	59	36	-	-	HYPH
cord-307860-iqk1yiw4	59	37	based	base	VBN
cord-307860-iqk1yiw4	59	38	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	59	39	N3	n3	NN
cord-307860-iqk1yiw4	59	40	(	(	-LRB-
cord-307860-iqk1yiw4	59	41	PRD_002214	PRD_002214	NNP
cord-307860-iqk1yiw4	59	42	)	)	-RRB-
cord-307860-iqk1yiw4	59	43	.	.	.
cord-307860-iqk1yiw4	60	1	The	the	DT
cord-307860-iqk1yiw4	60	2	structure	structure	NN
cord-307860-iqk1yiw4	60	3	was	be	VBD
cord-307860-iqk1yiw4	60	4	deposited	deposit	VBN
cord-307860-iqk1yiw4	60	5	in	in	IN
cord-307860-iqk1yiw4	60	6	PDB	PDB	NNP
cord-307860-iqk1yiw4	60	7	in	in	IN
cord-307860-iqk1yiw4	60	8	2020	2020	CD
cord-307860-iqk1yiw4	60	9	-	-	HYPH
cord-307860-iqk1yiw4	60	10	01	01	CD
cord-307860-iqk1yiw4	60	11	-	-	SYM
cord-307860-iqk1yiw4	60	12	26	26	CD
cord-307860-iqk1yiw4	60	13	and	and	CC
cord-307860-iqk1yiw4	60	14	released	release	VBN
cord-307860-iqk1yiw4	60	15	in	in	IN
cord-307860-iqk1yiw4	60	16	2020	2020	CD
cord-307860-iqk1yiw4	60	17	-	-	HYPH
cord-307860-iqk1yiw4	60	18	02	02	CD
cord-307860-iqk1yiw4	60	19	-	-	HYPH
cord-307860-iqk1yiw4	60	20	05	05	CD
cord-307860-iqk1yiw4	60	21	by	by	IN
cord-307860-iqk1yiw4	60	22	the	the	DT
cord-307860-iqk1yiw4	60	23	Liu	Liu	NNP
cord-307860-iqk1yiw4	60	24	X.	X.	NNP
cord-307860-iqk1yiw4	60	25	et	et	NNP
cord-307860-iqk1yiw4	60	26	al	al	NNP
cord-307860-iqk1yiw4	60	27	.	.	.
cord-307860-iqk1yiw4	61	1	[	[	-LRB-
cord-307860-iqk1yiw4	61	2	41	41	CD
cord-307860-iqk1yiw4	61	3	]	]	-RRB-
cord-307860-iqk1yiw4	61	4	.	.	.
cord-307860-iqk1yiw4	62	1	Two	two	CD
cord-307860-iqk1yiw4	62	2	PDB	PDB	NNP
cord-307860-iqk1yiw4	62	3	entries	entry	NNS
cord-307860-iqk1yiw4	62	4	(	(	-LRB-
cord-307860-iqk1yiw4	62	5	6M1D	6m1d	CD
cord-307860-iqk1yiw4	62	6	and	and	CC
cord-307860-iqk1yiw4	62	7	6M18	6m18	CD
cord-307860-iqk1yiw4	62	8	)	)	-RRB-
cord-307860-iqk1yiw4	62	9	of	of	IN
cord-307860-iqk1yiw4	62	10	the	the	DT
cord-307860-iqk1yiw4	62	11	human	human	JJ
cord-307860-iqk1yiw4	62	12	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	62	13	co	co	NN
cord-307860-iqk1yiw4	62	14	-	-	VBD
cord-307860-iqk1yiw4	62	15	crystallized	crystallize	VBN
cord-307860-iqk1yiw4	62	16	with	with	IN
cord-307860-iqk1yiw4	62	17	the	the	DT
cord-307860-iqk1yiw4	62	18	sodium	sodium	NN
cord-307860-iqk1yiw4	62	19	-	-	HYPH
cord-307860-iqk1yiw4	62	20	dependent	dependent	JJ
cord-307860-iqk1yiw4	62	21	neutral	neutral	JJ
cord-307860-iqk1yiw4	62	22	amino	amino	NN
cord-307860-iqk1yiw4	62	23	acid	acid	NN
cord-307860-iqk1yiw4	62	24	transporter	transporter	NN
cord-307860-iqk1yiw4	62	25	B(0)AT1were	b(0)at1were	RB
cord-307860-iqk1yiw4	62	26	added	add	VBD
cord-307860-iqk1yiw4	62	27	because	because	IN
cord-307860-iqk1yiw4	62	28	these	these	DT
cord-307860-iqk1yiw4	62	29	structures	structure	NNS
cord-307860-iqk1yiw4	62	30	are	be	VBP
cord-307860-iqk1yiw4	62	31	part	part	NN
cord-307860-iqk1yiw4	62	32	of	of	IN
cord-307860-iqk1yiw4	62	33	the	the	DT
cord-307860-iqk1yiw4	62	34	same	same	JJ
cord-307860-iqk1yiw4	62	35	work	work	NN
cord-307860-iqk1yiw4	62	36	with	with	IN
cord-307860-iqk1yiw4	62	37	the	the	DT
cord-307860-iqk1yiw4	62	38	spike	spike	NN
cord-307860-iqk1yiw4	62	39	-	-	HYPH
cord-307860-iqk1yiw4	62	40	receptor	receptor	NN
cord-307860-iqk1yiw4	62	41	binding	binding	NN
cord-307860-iqk1yiw4	62	42	domain	domain	NN
cord-307860-iqk1yiw4	63	1	(	(	-LRB-
cord-307860-iqk1yiw4	63	2	RBD)/ACE2/	rbd)/ace2/	IN
cord-307860-iqk1yiw4	63	3	B(0)AT1	b(0)at1	IN
cord-307860-iqk1yiw4	63	4	EM	em	NN
cord-307860-iqk1yiw4	63	5	-	-	HYPH
cord-307860-iqk1yiw4	63	6	structure	structure	NN
cord-307860-iqk1yiw4	64	1	(	(	-LRB-
cord-307860-iqk1yiw4	64	2	PDB	PDB	NNP
cord-307860-iqk1yiw4	64	3	ID	ID	NNP
cord-307860-iqk1yiw4	64	4	6M17	6m17	CD
cord-307860-iqk1yiw4	64	5	)	)	-RRB-
cord-307860-iqk1yiw4	65	1	[	[	-LRB-
cord-307860-iqk1yiw4	65	2	39	39	CD
cord-307860-iqk1yiw4	65	3	]	]	-RRB-
cord-307860-iqk1yiw4	65	4	.	.	.
cord-307860-iqk1yiw4	66	1	Three	three	CD
cord-307860-iqk1yiw4	66	2	nsp9	nsp9	DT
cord-307860-iqk1yiw4	66	3	structures	structure	NNS
cord-307860-iqk1yiw4	66	4	non	non	JJ
cord-307860-iqk1yiw4	66	5	-	-	JJ
cord-307860-iqk1yiw4	66	6	published	published	JJ
cord-307860-iqk1yiw4	66	7	in	in	IN
cord-307860-iqk1yiw4	66	8	the	the	DT
cord-307860-iqk1yiw4	66	9	peer	peer	NN
cord-307860-iqk1yiw4	66	10	-	-	HYPH
cord-307860-iqk1yiw4	66	11	reviewed	review	VBN
cord-307860-iqk1yiw4	66	12	papers	paper	NNS
cord-307860-iqk1yiw4	66	13	were	be	VBD
cord-307860-iqk1yiw4	66	14	included	include	VBN
cord-307860-iqk1yiw4	66	15	in	in	IN
cord-307860-iqk1yiw4	66	16	the	the	DT
cord-307860-iqk1yiw4	66	17	study	study	NN
cord-307860-iqk1yiw4	66	18	(	(	-LRB-
cord-307860-iqk1yiw4	66	19	PDB	PDB	NNP
cord-307860-iqk1yiw4	66	20	ID(s	ID(s	NNP
cord-307860-iqk1yiw4	66	21	)	)	-RRB-
cord-307860-iqk1yiw4	67	1	6W9Q	6w9q	CD
cord-307860-iqk1yiw4	67	2	,	,	,
cord-307860-iqk1yiw4	67	3	6W4B	6w4b	CD
cord-307860-iqk1yiw4	67	4	,	,	,
cord-307860-iqk1yiw4	67	5	and	and	CC
cord-307860-iqk1yiw4	67	6	6WXD	6wxd	CD
cord-307860-iqk1yiw4	67	7	)	)	-RRB-
cord-307860-iqk1yiw4	67	8	.	.	.
cord-307860-iqk1yiw4	68	1	Their	-PRON-	PRP$
cord-307860-iqk1yiw4	68	2	sequences	sequence	NNS
cord-307860-iqk1yiw4	68	3	were	be	VBD
cord-307860-iqk1yiw4	68	4	analyzed	analyze	VBN
cord-307860-iqk1yiw4	68	5	by	by	IN
cord-307860-iqk1yiw4	68	6	multiple	multiple	JJ
cord-307860-iqk1yiw4	68	7	sequence	sequence	NN
cord-307860-iqk1yiw4	68	8	alignment	alignment	NN
cord-307860-iqk1yiw4	68	9	and	and	CC
cord-307860-iqk1yiw4	68	10	compared	compare	VBN
cord-307860-iqk1yiw4	68	11	with	with	IN
cord-307860-iqk1yiw4	68	12	previous	previous	JJ
cord-307860-iqk1yiw4	68	13	works	work	NNS
cord-307860-iqk1yiw4	68	14	.	.	.
cord-307860-iqk1yiw4	69	1	The	the	DT
cord-307860-iqk1yiw4	69	2	selection	selection	NN
cord-307860-iqk1yiw4	69	3	flow	flow	NN
cord-307860-iqk1yiw4	69	4	of	of	IN
cord-307860-iqk1yiw4	69	5	the	the	DT
cord-307860-iqk1yiw4	69	6	70	70	CD
cord-307860-iqk1yiw4	69	7	PDB	PDB	NNP
cord-307860-iqk1yiw4	69	8	structures	structure	NNS
cord-307860-iqk1yiw4	69	9	included	include	VBN
cord-307860-iqk1yiw4	69	10	in	in	IN
cord-307860-iqk1yiw4	69	11	the	the	DT
cord-307860-iqk1yiw4	69	12	present	present	JJ
cord-307860-iqk1yiw4	69	13	review	review	NN
cord-307860-iqk1yiw4	69	14	is	be	VBZ
cord-307860-iqk1yiw4	69	15	shown	show	VBN
cord-307860-iqk1yiw4	69	16	in	in	IN
cord-307860-iqk1yiw4	69	17	Fig	Fig	NNP
cord-307860-iqk1yiw4	69	18	.	.	.
cord-307860-iqk1yiw4	70	1	1	1	LS
cord-307860-iqk1yiw4	70	2	.	.	.
cord-307860-iqk1yiw4	71	1	One	one	CD
cord-307860-iqk1yiw4	71	2	of	of	IN
cord-307860-iqk1yiw4	71	3	the	the	DT
cord-307860-iqk1yiw4	71	4	most	most	RBS
cord-307860-iqk1yiw4	71	5	urgent	urgent	JJ
cord-307860-iqk1yiw4	71	6	aims	aim	NNS
cord-307860-iqk1yiw4	71	7	of	of	IN
cord-307860-iqk1yiw4	71	8	controlling	control	VBG
cord-307860-iqk1yiw4	71	9	the	the	DT
cord-307860-iqk1yiw4	71	10	SARS	SARS	NNP
cord-307860-iqk1yiw4	71	11	-	-	HYPH
cord-307860-iqk1yiw4	71	12	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	71	13	pandemic	pandemic	NN
cord-307860-iqk1yiw4	71	14	is	be	VBZ
cord-307860-iqk1yiw4	71	15	to	to	TO
cord-307860-iqk1yiw4	71	16	find	find	VB
cord-307860-iqk1yiw4	71	17	out	out	RP
cord-307860-iqk1yiw4	71	18	an	an	DT
cord-307860-iqk1yiw4	71	19	efficient	efficient	JJ
cord-307860-iqk1yiw4	71	20	therapy	therapy	NN
cord-307860-iqk1yiw4	71	21	.	.	.
cord-307860-iqk1yiw4	72	1	Healthcare	healthcare	NN
cord-307860-iqk1yiw4	72	2	professionals	professional	NNS
cord-307860-iqk1yiw4	72	3	have	have	VBP
cord-307860-iqk1yiw4	72	4	established	establish	VBN
cord-307860-iqk1yiw4	72	5	different	different	JJ
cord-307860-iqk1yiw4	72	6	clinical	clinical	JJ
cord-307860-iqk1yiw4	72	7	practice	practice	NN
cord-307860-iqk1yiw4	72	8	guidelines	guideline	NNS
cord-307860-iqk1yiw4	72	9	.	.	.
cord-307860-iqk1yiw4	73	1	The	the	DT
cord-307860-iqk1yiw4	73	2	update	update	NN
cord-307860-iqk1yiw4	73	3	of	of	IN
cord-307860-iqk1yiw4	73	4	the	the	DT
cord-307860-iqk1yiw4	73	5	clinical	clinical	JJ
cord-307860-iqk1yiw4	73	6	results	result	NNS
cord-307860-iqk1yiw4	73	7	helps	help	VBZ
cord-307860-iqk1yiw4	73	8	the	the	DT
cord-307860-iqk1yiw4	73	9	medical	medical	JJ
cord-307860-iqk1yiw4	73	10	teams	team	NNS
cord-307860-iqk1yiw4	73	11	to	to	TO
cord-307860-iqk1yiw4	73	12	monitor	monitor	VB
cord-307860-iqk1yiw4	73	13	and	and	CC
cord-307860-iqk1yiw4	73	14	refine	refine	VB
cord-307860-iqk1yiw4	73	15	their	-PRON-	PRP$
cord-307860-iqk1yiw4	73	16	therapy	therapy	NN
cord-307860-iqk1yiw4	73	17	,	,	,
cord-307860-iqk1yiw4	73	18	but	but	CC
cord-307860-iqk1yiw4	73	19	a	a	DT
cord-307860-iqk1yiw4	73	20	conclusion	conclusion	NN
cord-307860-iqk1yiw4	73	21	could	could	MD
cord-307860-iqk1yiw4	73	22	be	be	VB
cord-307860-iqk1yiw4	73	23	drawn	draw	VBN
cord-307860-iqk1yiw4	73	24	only	only	RB
cord-307860-iqk1yiw4	73	25	at	at	IN
cord-307860-iqk1yiw4	73	26	the	the	DT
cord-307860-iqk1yiw4	73	27	end	end	NN
cord-307860-iqk1yiw4	73	28	of	of	IN
cord-307860-iqk1yiw4	73	29	the	the	DT
cord-307860-iqk1yiw4	73	30	SARS	SARS	NNP
cord-307860-iqk1yiw4	73	31	-	-	HYPH
cord-307860-iqk1yiw4	73	32	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	73	33	pandemic	pandemic	NN
cord-307860-iqk1yiw4	73	34	.	.	.
cord-307860-iqk1yiw4	74	1	There	there	EX
cord-307860-iqk1yiw4	74	2	is	be	VBZ
cord-307860-iqk1yiw4	74	3	no	no	DT
cord-307860-iqk1yiw4	74	4	specific	specific	JJ
cord-307860-iqk1yiw4	74	5	cure	cure	NN
cord-307860-iqk1yiw4	74	6	for	for	IN
cord-307860-iqk1yiw4	74	7	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	74	8	,	,	,
cord-307860-iqk1yiw4	74	9	which	which	WDT
cord-307860-iqk1yiw4	74	10	explains	explain	VBZ
cord-307860-iqk1yiw4	74	11	the	the	DT
cord-307860-iqk1yiw4	74	12	race	race	NN
cord-307860-iqk1yiw4	74	13	to	to	TO
cord-307860-iqk1yiw4	74	14	discover	discover	VB
cord-307860-iqk1yiw4	74	15	effective	effective	JJ
cord-307860-iqk1yiw4	74	16	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	74	17	and	and	CC
cord-307860-iqk1yiw4	74	18	a	a	DT
cord-307860-iqk1yiw4	74	19	universal	universal	JJ
cord-307860-iqk1yiw4	74	20	vaccine	vaccine	NN
cord-307860-iqk1yiw4	74	21	.	.	.
cord-307860-iqk1yiw4	75	1	Despite	despite	IN
cord-307860-iqk1yiw4	75	2	numerous	numerous	JJ
cord-307860-iqk1yiw4	75	3	SARS	SARS	NNP
cord-307860-iqk1yiw4	75	4	-	-	HYPH
cord-307860-iqk1yiw4	75	5	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	75	6	PDB	PDB	NNP
cord-307860-iqk1yiw4	75	7	structures	structure	NNS
cord-307860-iqk1yiw4	75	8	co	co	VBD
cord-307860-iqk1yiw4	75	9	-	-	VBD
cord-307860-iqk1yiw4	75	10	crystallized	crystallize	VBN
cord-307860-iqk1yiw4	75	11	with	with	IN
cord-307860-iqk1yiw4	75	12	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	75	13	,	,	,
cord-307860-iqk1yiw4	75	14	only	only	RB
cord-307860-iqk1yiw4	75	15	a	a	DT
cord-307860-iqk1yiw4	75	16	few	few	JJ
cord-307860-iqk1yiw4	75	17	of	of	IN
cord-307860-iqk1yiw4	75	18	them	-PRON-	PRP
cord-307860-iqk1yiw4	75	19	have	have	VBP
cord-307860-iqk1yiw4	75	20	been	be	VBN
cord-307860-iqk1yiw4	75	21	publishing	publish	VBG
cord-307860-iqk1yiw4	75	22	in	in	IN
cord-307860-iqk1yiw4	75	23	peer	peer	NN
cord-307860-iqk1yiw4	75	24	-	-	HYPH
cord-307860-iqk1yiw4	75	25	reviewed	review	VBN
cord-307860-iqk1yiw4	75	26	papers	paper	NNS
cord-307860-iqk1yiw4	75	27	.	.	.
cord-307860-iqk1yiw4	76	1	Many	many	JJ
cord-307860-iqk1yiw4	76	2	research	research	NN
cord-307860-iqk1yiw4	76	3	teams	team	NNS
cord-307860-iqk1yiw4	76	4	focus	focus	VBP
cord-307860-iqk1yiw4	76	5	on	on	IN
cord-307860-iqk1yiw4	76	6	designing	design	VBG
cord-307860-iqk1yiw4	76	7	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	76	8	of	of	IN
cord-307860-iqk1yiw4	76	9	viral	viral	JJ
cord-307860-iqk1yiw4	76	10	proteases	protease	NNS
cord-307860-iqk1yiw4	76	11	due	due	IN
cord-307860-iqk1yiw4	76	12	to	to	IN
cord-307860-iqk1yiw4	76	13	their	-PRON-	PRP$
cord-307860-iqk1yiw4	76	14	role	role	NN
cord-307860-iqk1yiw4	76	15	in	in	IN
cord-307860-iqk1yiw4	76	16	viral	viral	JJ
cord-307860-iqk1yiw4	76	17	replication	replication	NN
cord-307860-iqk1yiw4	76	18	[	[	-LRB-
cord-307860-iqk1yiw4	76	19	51	51	CD
cord-307860-iqk1yiw4	76	20	]	]	-RRB-
cord-307860-iqk1yiw4	76	21	.	.	.
cord-307860-iqk1yiw4	77	1	There	there	EX
cord-307860-iqk1yiw4	77	2	are	be	VBP
cord-307860-iqk1yiw4	77	3	two	two	CD
cord-307860-iqk1yiw4	77	4	viral	viral	JJ
cord-307860-iqk1yiw4	77	5	proteases	protease	NNS
cord-307860-iqk1yiw4	77	6	:	:	:
cord-307860-iqk1yiw4	77	7	main	main	JJ
cord-307860-iqk1yiw4	77	8	protease/3C	protease/3C	NNP
cord-307860-iqk1yiw4	77	9	-	-	HYPH
cord-307860-iqk1yiw4	77	10	like	like	JJ
cord-307860-iqk1yiw4	77	11	protease	protease	NN
cord-307860-iqk1yiw4	77	12	(	(	-LRB-
cord-307860-iqk1yiw4	77	13	M	M	NNP
cord-307860-iqk1yiw4	77	14	pro	pro	JJ
cord-307860-iqk1yiw4	77	15	/3CL	/3CL	NNP
cord-307860-iqk1yiw4	77	16	pro	pro	NNP
cord-307860-iqk1yiw4	77	17	)	)	-RRB-
cord-307860-iqk1yiw4	77	18	and	and	CC
cord-307860-iqk1yiw4	77	19	papainlike	papainlike	JJ
cord-307860-iqk1yiw4	77	20	protease	protease	NN
cord-307860-iqk1yiw4	77	21	(	(	-LRB-
cord-307860-iqk1yiw4	77	22	PL	pl	NN
cord-307860-iqk1yiw4	77	23	pro	pro	FW
cord-307860-iqk1yiw4	77	24	)	)	-RRB-
cord-307860-iqk1yiw4	77	25	.	.	.
cord-307860-iqk1yiw4	78	1	These	these	DT
cord-307860-iqk1yiw4	78	2	proteases	protease	NNS
cord-307860-iqk1yiw4	78	3	cleave	cleave	VBP
cord-307860-iqk1yiw4	78	4	the	the	DT
cord-307860-iqk1yiw4	78	5	polyprotein	polyprotein	NNP
cord-307860-iqk1yiw4	78	6	1ab	1ab	NN
cord-307860-iqk1yiw4	78	7	(	(	-LRB-
cord-307860-iqk1yiw4	78	8	UniProtKB	uniprotkb	CD
cord-307860-iqk1yiw4	78	9	P0C6X7	P0C6X7	NNP
cord-307860-iqk1yiw4	78	10	)	)	-RRB-
cord-307860-iqk1yiw4	78	11	to	to	TO
cord-307860-iqk1yiw4	78	12	yield	yield	VB
cord-307860-iqk1yiw4	78	13	the	the	DT
cord-307860-iqk1yiw4	78	14	viral	viral	JJ
cord-307860-iqk1yiw4	78	15	proteins	protein	NNS
cord-307860-iqk1yiw4	78	16	[	[	-LRB-
cord-307860-iqk1yiw4	78	17	44	44	CD
cord-307860-iqk1yiw4	78	18	]	]	-RRB-
cord-307860-iqk1yiw4	78	19	.	.	.
cord-307860-iqk1yiw4	79	1	There	there	EX
cord-307860-iqk1yiw4	79	2	are	be	VBP
cord-307860-iqk1yiw4	79	3	seven	seven	CD
cord-307860-iqk1yiw4	79	4	PDB	PDB	NNP
cord-307860-iqk1yiw4	79	5	structures	structure	NNS
cord-307860-iqk1yiw4	79	6	of	of	IN
cord-307860-iqk1yiw4	79	7	SARS	SARS	NNP
cord-307860-iqk1yiw4	79	8	-	-	HYPH
cord-307860-iqk1yiw4	79	9	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	80	1	3CL	3cl	CD
cord-307860-iqk1yiw4	81	1	pro	pro	JJ
cord-307860-iqk1yiw4	81	2	cocrystallized	cocrystallize	VBN
cord-307860-iqk1yiw4	81	3	with	with	IN
cord-307860-iqk1yiw4	81	4	antiviral	antiviral	JJ
cord-307860-iqk1yiw4	81	5	drug	drug	NN
cord-307860-iqk1yiw4	81	6	candidates	candidate	NNS
cord-307860-iqk1yiw4	81	7	.	.	.
cord-307860-iqk1yiw4	82	1	Two	two	CD
cord-307860-iqk1yiw4	82	2	structures	structure	NNS
cord-307860-iqk1yiw4	82	3	are	be	VBP
cord-307860-iqk1yiw4	82	4	co	co	JJ
cord-307860-iqk1yiw4	82	5	-	-	JJ
cord-307860-iqk1yiw4	82	6	crystallized	crystallize	VBN
cord-307860-iqk1yiw4	83	1	with	with	IN
cord-307860-iqk1yiw4	83	2	N3	N3	NNP
cord-307860-iqk1yiw4	83	3	(	(	-LRB-
cord-307860-iqk1yiw4	83	4	PRD_002214	prd_002214	NN
cord-307860-iqk1yiw4	83	5	)	)	-RRB-
cord-307860-iqk1yiw4	84	1	(	(	-LRB-
cord-307860-iqk1yiw4	84	2	PDB	PDB	NNP
cord-307860-iqk1yiw4	84	3	ID(s	ID(s	NNP
cord-307860-iqk1yiw4	84	4	)	)	-RRB-
cord-307860-iqk1yiw4	85	1	6LU7	6lu7	CD
cord-307860-iqk1yiw4	86	1	and	and	CC
cord-307860-iqk1yiw4	86	2	7BQY	7bqy	LS
cord-307860-iqk1yiw4	86	3	)	)	-RRB-
cord-307860-iqk1yiw4	87	1	[	[	-LRB-
cord-307860-iqk1yiw4	87	2	41	41	CD
cord-307860-iqk1yiw4	87	3	]	]	-RRB-
cord-307860-iqk1yiw4	87	4	.	.	.
cord-307860-iqk1yiw4	88	1	The	the	DT
cord-307860-iqk1yiw4	88	2	6LZE	6LZE	NNP
cord-307860-iqk1yiw4	88	3	and	and	CC
cord-307860-iqk1yiw4	88	4	6M0	6m0	CD
cord-307860-iqk1yiw4	88	5	K	K	NNP
cord-307860-iqk1yiw4	88	6	structures	structure	NNS
cord-307860-iqk1yiw4	88	7	are	be	VBP
cord-307860-iqk1yiw4	88	8	co	co	JJ
cord-307860-iqk1yiw4	88	9	-	-	VBN
cord-307860-iqk1yiw4	88	10	crystallized	crystallize	VBN
cord-307860-iqk1yiw4	88	11	with	with	IN
cord-307860-iqk1yiw4	88	12	compounds	compound	NNS
cord-307860-iqk1yiw4	88	13	11a	11a	NNS
cord-307860-iqk1yiw4	88	14	and	and	CC
cord-307860-iqk1yiw4	88	15	11b	11b	NNS
cord-307860-iqk1yiw4	88	16	,	,	,
cord-307860-iqk1yiw4	88	17	respectively	respectively	RB
cord-307860-iqk1yiw4	88	18	[	[	-LRB-
cord-307860-iqk1yiw4	88	19	42	42	CD
cord-307860-iqk1yiw4	88	20	]	]	-RRB-
cord-307860-iqk1yiw4	88	21	.	.	.
cord-307860-iqk1yiw4	89	1	Two	two	CD
cord-307860-iqk1yiw4	89	2	structures	structure	NNS
cord-307860-iqk1yiw4	89	3	are	be	VBP
cord-307860-iqk1yiw4	89	4	co	co	JJ
cord-307860-iqk1yiw4	89	5	-	-	JJ
cord-307860-iqk1yiw4	89	6	crystallized	crystallize	VBN
cord-307860-iqk1yiw4	90	1	with	with	IN
cord-307860-iqk1yiw4	90	2	alphaketoamide	alphaketoamide	NNP
cord-307860-iqk1yiw4	90	3	13b	13b	NNS
cord-307860-iqk1yiw4	90	4	(	(	-LRB-
cord-307860-iqk1yiw4	90	5	PDB	PDB	NNP
cord-307860-iqk1yiw4	90	6	ID(s	ID(s	NNP
cord-307860-iqk1yiw4	90	7	)	)	-RRB-
cord-307860-iqk1yiw4	91	1	6Y2F	6y2f	CD
cord-307860-iqk1yiw4	91	2	and	and	CC
cord-307860-iqk1yiw4	91	3	6Y2	6y2	CD
cord-307860-iqk1yiw4	91	4	G	g	NN
cord-307860-iqk1yiw4	91	5	)	)	-RRB-
cord-307860-iqk1yiw4	91	6	[	[	-LRB-
cord-307860-iqk1yiw4	91	7	44	44	CD
cord-307860-iqk1yiw4	91	8	]	]	-RRB-
cord-307860-iqk1yiw4	91	9	.	.	.
cord-307860-iqk1yiw4	92	1	The	the	DT
cord-307860-iqk1yiw4	92	2	7BUY	7BUY	NNP
cord-307860-iqk1yiw4	92	3	structure	structure	NN
cord-307860-iqk1yiw4	92	4	is	be	VBZ
cord-307860-iqk1yiw4	92	5	co	co	VBN
cord-307860-iqk1yiw4	92	6	-	-	VBN
cord-307860-iqk1yiw4	92	7	crystallized	crystallize	VBN
cord-307860-iqk1yiw4	92	8	with	with	IN
cord-307860-iqk1yiw4	92	9	the	the	DT
cord-307860-iqk1yiw4	92	10	antineoplastic	antineoplastic	JJ
cord-307860-iqk1yiw4	92	11	drug	drug	NN
cord-307860-iqk1yiw4	92	12	carmofur	carmofur	NNP
cord-307860-iqk1yiw4	92	13	[	[	-LRB-
cord-307860-iqk1yiw4	92	14	43	43	CD
cord-307860-iqk1yiw4	92	15	]	]	-RRB-
cord-307860-iqk1yiw4	92	16	.	.	.
cord-307860-iqk1yiw4	93	1	There	there	EX
cord-307860-iqk1yiw4	93	2	is	be	VBZ
cord-307860-iqk1yiw4	93	3	a	a	DT
cord-307860-iqk1yiw4	93	4	cryo	cryo	NN
cord-307860-iqk1yiw4	93	5	-	-	HYPH
cord-307860-iqk1yiw4	93	6	EM	em	NN
cord-307860-iqk1yiw4	93	7	crystal	crystal	NN
cord-307860-iqk1yiw4	93	8	structure	structure	NN
cord-307860-iqk1yiw4	93	9	of	of	IN
cord-307860-iqk1yiw4	93	10	the	the	DT
cord-307860-iqk1yiw4	93	11	SARS	SARS	NNP
cord-307860-iqk1yiw4	93	12	-	-	HYPH
cord-307860-iqk1yiw4	93	13	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	93	14	RNA	RNA	NNP
cord-307860-iqk1yiw4	93	15	-	-	HYPH
cord-307860-iqk1yiw4	93	16	dependent	dependent	JJ
cord-307860-iqk1yiw4	93	17	RNA	RNA	NNP
cord-307860-iqk1yiw4	93	18	polymerase	polymerase	NN
cord-307860-iqk1yiw4	93	19	(	(	-LRB-
cord-307860-iqk1yiw4	93	20	RdRp	RdRp	NNP
cord-307860-iqk1yiw4	93	21	)	)	-RRB-
cord-307860-iqk1yiw4	93	22	complex	complex	NNP
cord-307860-iqk1yiw4	93	23	(	(	-LRB-
cord-307860-iqk1yiw4	93	24	nsp12	nsp12	NNS
cord-307860-iqk1yiw4	93	25	/	/	SYM
cord-307860-iqk1yiw4	93	26	nsp8	nsp8	NN
cord-307860-iqk1yiw4	93	27	/	/	SYM
cord-307860-iqk1yiw4	93	28	nsp7	nsp7	NN
cord-307860-iqk1yiw4	93	29	)	)	-RRB-
cord-307860-iqk1yiw4	93	30	with	with	IN
cord-307860-iqk1yiw4	93	31	the	the	DT
cord-307860-iqk1yiw4	93	32	antiviral	antiviral	JJ
cord-307860-iqk1yiw4	93	33	drug	drug	NN
cord-307860-iqk1yiw4	93	34	remdesivir	remdesivir	NNP
cord-307860-iqk1yiw4	93	35	(	(	-LRB-
cord-307860-iqk1yiw4	93	36	PDB	PDB	NNP
cord-307860-iqk1yiw4	93	37	ID	ID	NNP
cord-307860-iqk1yiw4	93	38	7BV2	7bv2	CD
cord-307860-iqk1yiw4	93	39	)	)	-RRB-
cord-307860-iqk1yiw4	94	1	[	[	-LRB-
cord-307860-iqk1yiw4	94	2	37	37	CD
cord-307860-iqk1yiw4	94	3	]	]	-RRB-
cord-307860-iqk1yiw4	94	4	.	.	.
cord-307860-iqk1yiw4	95	1	However	however	RB
cord-307860-iqk1yiw4	95	2	,	,	,
cord-307860-iqk1yiw4	95	3	these	these	DT
cord-307860-iqk1yiw4	95	4	compounds	compound	NNS
cord-307860-iqk1yiw4	95	5	are	be	VBP
cord-307860-iqk1yiw4	95	6	not	not	RB
cord-307860-iqk1yiw4	95	7	optimal	optimal	JJ
cord-307860-iqk1yiw4	95	8	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	95	9	of	of	IN
cord-307860-iqk1yiw4	95	10	SARS	SARS	NNP
cord-307860-iqk1yiw4	95	11	-	-	HYPH
cord-307860-iqk1yiw4	95	12	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	95	13	.	.	.
cord-307860-iqk1yiw4	96	1	The	the	DT
cord-307860-iqk1yiw4	96	2	comparison	comparison	NN
cord-307860-iqk1yiw4	96	3	of	of	IN
cord-307860-iqk1yiw4	96	4	the	the	DT
cord-307860-iqk1yiw4	96	5	antiviral	antiviral	JJ
cord-307860-iqk1yiw4	96	6	drug	drug	NN
cord-307860-iqk1yiw4	96	7	candidates	candidate	NNS
cord-307860-iqk1yiw4	96	8	against	against	IN
cord-307860-iqk1yiw4	96	9	SARS	SARS	NNP
cord-307860-iqk1yiw4	96	10	-	-	HYPH
cord-307860-iqk1yiw4	96	11	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	96	12	and	and	CC
cord-307860-iqk1yiw4	96	13	other	other	JJ
cord-307860-iqk1yiw4	96	14	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	96	15	is	be	VBZ
cord-307860-iqk1yiw4	96	16	shown	show	VBN
cord-307860-iqk1yiw4	96	17	in	in	IN
cord-307860-iqk1yiw4	96	18	Table	Table	NNP
cord-307860-iqk1yiw4	96	19	1	1	CD
cord-307860-iqk1yiw4	96	20	.	.	.
cord-307860-iqk1yiw4	97	1	The	the	DT
cord-307860-iqk1yiw4	97	2	3CL	3cl	CD
cord-307860-iqk1yiw4	97	3	pro	pro	JJ
cord-307860-iqk1yiw4	97	4	(	(	-LRB-
cord-307860-iqk1yiw4	97	5	UniProtKB	uniprotkb	CD
cord-307860-iqk1yiw4	97	6	P0DTD1	P0DTD1	NNS
cord-307860-iqk1yiw4	97	7	)	)	-RRB-
cord-307860-iqk1yiw4	97	8	is	be	VBZ
cord-307860-iqk1yiw4	97	9	extensively	extensively	RB
cord-307860-iqk1yiw4	97	10	studied	study	VBN
cord-307860-iqk1yiw4	97	11	for	for	IN
cord-307860-iqk1yiw4	97	12	designing	design	VBG
cord-307860-iqk1yiw4	97	13	of	of	IN
cord-307860-iqk1yiw4	97	14	new	new	JJ
cord-307860-iqk1yiw4	97	15	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	97	16	due	due	IN
cord-307860-iqk1yiw4	97	17	to	to	IN
cord-307860-iqk1yiw4	97	18	its	-PRON-	PRP$
cord-307860-iqk1yiw4	97	19	unique	unique	JJ
cord-307860-iqk1yiw4	97	20	characteristics	characteristic	NNS
cord-307860-iqk1yiw4	97	21	.	.	.
cord-307860-iqk1yiw4	98	1	It	-PRON-	PRP
cord-307860-iqk1yiw4	98	2	is	be	VBZ
cord-307860-iqk1yiw4	98	3	also	also	RB
cord-307860-iqk1yiw4	98	4	known	know	VBN
cord-307860-iqk1yiw4	98	5	as	as	IN
cord-307860-iqk1yiw4	98	6	non	non	JJ
cord-307860-iqk1yiw4	98	7	-	-	JJ
cord-307860-iqk1yiw4	98	8	structural	structural	JJ
cord-307860-iqk1yiw4	98	9	protein	protein	NN
cord-307860-iqk1yiw4	98	10	5	5	CD
cord-307860-iqk1yiw4	98	11	(	(	-LRB-
cord-307860-iqk1yiw4	98	12	nsp5	nsp5	NN
cord-307860-iqk1yiw4	98	13	)	)	-RRB-
cord-307860-iqk1yiw4	98	14	.	.	.
cord-307860-iqk1yiw4	99	1	It	-PRON-	PRP
cord-307860-iqk1yiw4	99	2	is	be	VBZ
cord-307860-iqk1yiw4	99	3	a	a	DT
cord-307860-iqk1yiw4	99	4	cysteine	cysteine	NN
cord-307860-iqk1yiw4	99	5	protease	protease	NN
cord-307860-iqk1yiw4	99	6	involved	involve	VBN
cord-307860-iqk1yiw4	99	7	in	in	IN
cord-307860-iqk1yiw4	99	8	the	the	DT
cord-307860-iqk1yiw4	99	9	cleavage	cleavage	NN
cord-307860-iqk1yiw4	99	10	of	of	IN
cord-307860-iqk1yiw4	99	11	the	the	DT
cord-307860-iqk1yiw4	99	12	viral	viral	JJ
cord-307860-iqk1yiw4	99	13	polyproteins	polyprotein	NNS
cord-307860-iqk1yiw4	99	14	1a	1a	CD
cord-307860-iqk1yiw4	99	15	and	and	CC
cord-307860-iqk1yiw4	99	16	1ab	1ab	NN
cord-307860-iqk1yiw4	99	17	.	.	.
cord-307860-iqk1yiw4	100	1	Moreover	moreover	RB
cord-307860-iqk1yiw4	100	2	,	,	,
cord-307860-iqk1yiw4	100	3	there	there	EX
cord-307860-iqk1yiw4	100	4	are	be	VBP
cord-307860-iqk1yiw4	100	5	no	no	DT
cord-307860-iqk1yiw4	100	6	human	human	JJ
cord-307860-iqk1yiw4	100	7	counterparts	counterpart	NNS
cord-307860-iqk1yiw4	100	8	for	for	IN
cord-307860-iqk1yiw4	100	9	3CL	3cl	CD
cord-307860-iqk1yiw4	100	10	pro	pro	JJ
cord-307860-iqk1yiw4	100	11	[	[	-LRB-
cord-307860-iqk1yiw4	100	12	52	52	CD
cord-307860-iqk1yiw4	100	13	]	]	-RRB-
cord-307860-iqk1yiw4	101	1	[	[	-LRB-
cord-307860-iqk1yiw4	101	2	53	53	CD
cord-307860-iqk1yiw4	101	3	]	]	-RRB-
cord-307860-iqk1yiw4	102	1	[	[	-LRB-
cord-307860-iqk1yiw4	102	2	54	54	CD
cord-307860-iqk1yiw4	102	3	]	]	-RRB-
cord-307860-iqk1yiw4	103	1	[	[	-LRB-
cord-307860-iqk1yiw4	103	2	55	55	CD
cord-307860-iqk1yiw4	103	3	]	]	-RRB-
cord-307860-iqk1yiw4	103	4	[	[	-LRB-
cord-307860-iqk1yiw4	103	5	56	56	CD
cord-307860-iqk1yiw4	103	6	]	]	-RRB-
cord-307860-iqk1yiw4	103	7	[	[	-LRB-
cord-307860-iqk1yiw4	103	8	57	57	CD
cord-307860-iqk1yiw4	103	9	]	]	-RRB-
cord-307860-iqk1yiw4	103	10	.	.	.
cord-307860-iqk1yiw4	104	1	The	the	DT
cord-307860-iqk1yiw4	104	2	3CL	3cl	CD
cord-307860-iqk1yiw4	104	3	pro	pro	NN
cord-307860-iqk1yiw4	104	4	is	be	VBZ
cord-307860-iqk1yiw4	104	5	one	one	CD
cord-307860-iqk1yiw4	104	6	of	of	IN
cord-307860-iqk1yiw4	104	7	the	the	DT
cord-307860-iqk1yiw4	104	8	targets	target	NNS
cord-307860-iqk1yiw4	104	9	for	for	IN
cord-307860-iqk1yiw4	104	10	the	the	DT
cord-307860-iqk1yiw4	104	11	control	control	NN
cord-307860-iqk1yiw4	104	12	of	of	IN
cord-307860-iqk1yiw4	104	13	zoonotic	zoonotic	JJ
cord-307860-iqk1yiw4	104	14	reservoir	reservoir	NN
cord-307860-iqk1yiw4	104	15	of	of	IN
cord-307860-iqk1yiw4	104	16	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	104	17	.	.	.
cord-307860-iqk1yiw4	105	1	The	the	DT
cord-307860-iqk1yiw4	105	2	peptidomimetics	peptidomimetic	NNS
cord-307860-iqk1yiw4	105	3	with	with	IN
cord-307860-iqk1yiw4	105	4	3-thiophene	3-thiophene	CD
cord-307860-iqk1yiw4	105	5	and	and	CC
cord-307860-iqk1yiw4	105	6	1-methylbenzotriazole	1-methylbenzotriazole	CD
cord-307860-iqk1yiw4	105	7	backbones	backbone	NNS
cord-307860-iqk1yiw4	105	8	inhibit	inhibit	VBP
cord-307860-iqk1yiw4	105	9	the	the	DT
cord-307860-iqk1yiw4	105	10	bat	bat	NN
cord-307860-iqk1yiw4	105	11	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	105	12	HKU4-CoV	HKU4-CoV	NNP
cord-307860-iqk1yiw4	105	13	and	and	CC
cord-307860-iqk1yiw4	105	14	HKU5-CoV	hku5-cov	NN
cord-307860-iqk1yiw4	105	15	at	at	IN
cord-307860-iqk1yiw4	105	16	sub	sub	JJ
cord-307860-iqk1yiw4	105	17	-	-	JJ
cord-307860-iqk1yiw4	105	18	micromolar	micromolar	JJ
cord-307860-iqk1yiw4	105	19	concentrations	concentration	NNS
cord-307860-iqk1yiw4	105	20	[	[	-LRB-
cord-307860-iqk1yiw4	105	21	58	58	CD
cord-307860-iqk1yiw4	105	22	]	]	-RRB-
cord-307860-iqk1yiw4	105	23	.	.	.
cord-307860-iqk1yiw4	106	1	The	the	DT
cord-307860-iqk1yiw4	106	2	need	need	NN
cord-307860-iqk1yiw4	106	3	for	for	IN
cord-307860-iqk1yiw4	106	4	specific	specific	JJ
cord-307860-iqk1yiw4	106	5	treatment	treatment	NN
cord-307860-iqk1yiw4	106	6	of	of	IN
cord-307860-iqk1yiw4	106	7	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	106	8	had	have	VBD
cord-307860-iqk1yiw4	106	9	led	lead	VBN
cord-307860-iqk1yiw4	106	10	to	to	IN
cord-307860-iqk1yiw4	106	11	testing	test	VBG
cord-307860-iqk1yiw4	106	12	the	the	DT
cord-307860-iqk1yiw4	106	13	inhibitory	inhibitory	JJ
cord-307860-iqk1yiw4	106	14	activity	activity	NN
cord-307860-iqk1yiw4	106	15	of	of	IN
cord-307860-iqk1yiw4	106	16	other	other	JJ
cord-307860-iqk1yiw4	106	17	antiviral	antiviral	JJ
cord-307860-iqk1yiw4	106	18	drugs	drug	NNS
cord-307860-iqk1yiw4	106	19	.	.	.
cord-307860-iqk1yiw4	107	1	At	at	IN
cord-307860-iqk1yiw4	107	2	the	the	DT
cord-307860-iqk1yiw4	107	3	beginning	beginning	NN
cord-307860-iqk1yiw4	107	4	of	of	IN
cord-307860-iqk1yiw4	107	5	the	the	DT
cord-307860-iqk1yiw4	107	6	SARS	SARS	NNP
cord-307860-iqk1yiw4	107	7	-	-	HYPH
cord-307860-iqk1yiw4	107	8	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	107	9	pandemic	pandemic	NN
cord-307860-iqk1yiw4	107	10	,	,	,
cord-307860-iqk1yiw4	107	11	Wang	Wang	NNP
cord-307860-iqk1yiw4	107	12	et	et	NNP
cord-307860-iqk1yiw4	107	13	al	al	NNP
cord-307860-iqk1yiw4	107	14	.	.	.
cord-307860-iqk1yiw4	108	1	published	publish	VBD
cord-307860-iqk1yiw4	108	2	the	the	DT
cord-307860-iqk1yiw4	108	3	comparison	comparison	NN
cord-307860-iqk1yiw4	108	4	of	of	IN
cord-307860-iqk1yiw4	108	5	inhibitory	inhibitory	JJ
cord-307860-iqk1yiw4	108	6	activity	activity	NN
cord-307860-iqk1yiw4	108	7	of	of	IN
cord-307860-iqk1yiw4	108	8	five	five	CD
cord-307860-iqk1yiw4	108	9	antiviral	antiviral	JJ
cord-307860-iqk1yiw4	108	10	drugs	drug	NNS
cord-307860-iqk1yiw4	108	11	(	(	-LRB-
cord-307860-iqk1yiw4	108	12	ribavirin	ribavirin	NN
cord-307860-iqk1yiw4	108	13	,	,	,
cord-307860-iqk1yiw4	108	14	penciclovir	penciclovir	NNP
cord-307860-iqk1yiw4	108	15	,	,	,
cord-307860-iqk1yiw4	108	16	favipiravir	favipiravir	NNP
cord-307860-iqk1yiw4	108	17	,	,	,
cord-307860-iqk1yiw4	108	18	nefamostat	nefamostat	NNP
cord-307860-iqk1yiw4	108	19	,	,	,
cord-307860-iqk1yiw4	108	20	and	and	CC
cord-307860-iqk1yiw4	108	21	remdesivir	remdesivir	NNP
cord-307860-iqk1yiw4	108	22	)	)	-RRB-
cord-307860-iqk1yiw4	108	23	and	and	CC
cord-307860-iqk1yiw4	108	24	two	two	CD
cord-307860-iqk1yiw4	108	25	antiprotozoal	antiprotozoal	NNP
cord-307860-iqk1yiw4	108	26	drugs	drug	NNS
cord-307860-iqk1yiw4	108	27	(	(	-LRB-
cord-307860-iqk1yiw4	108	28	nitazoxanide	nitazoxanide	NNP
cord-307860-iqk1yiw4	108	29	,	,	,
cord-307860-iqk1yiw4	108	30	and	and	CC
cord-307860-iqk1yiw4	108	31	cloroquine	cloroquine	NNP
cord-307860-iqk1yiw4	108	32	)	)	-RRB-
cord-307860-iqk1yiw4	108	33	.	.	.
cord-307860-iqk1yiw4	109	1	The	the	DT
cord-307860-iqk1yiw4	109	2	EC50	EC50	NNP
cord-307860-iqk1yiw4	109	3	of	of	IN
cord-307860-iqk1yiw4	109	4	remdesivir	remdesivir	NNP
cord-307860-iqk1yiw4	109	5	and	and	CC
cord-307860-iqk1yiw4	109	6	cloroquine	cloroquine	NN
cord-307860-iqk1yiw4	109	7	against	against	IN
cord-307860-iqk1yiw4	109	8	SARS	SARS	NNP
cord-307860-iqk1yiw4	109	9	-	-	HYPH
cord-307860-iqk1yiw4	109	10	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	109	11	are	be	VBP
cord-307860-iqk1yiw4	109	12	0.72	0.72	CD
cord-307860-iqk1yiw4	109	13	μM	μm	NN
cord-307860-iqk1yiw4	109	14	and	and	CC
cord-307860-iqk1yiw4	109	15	1.13	1.13	CD
cord-307860-iqk1yiw4	109	16	μM	μm	NN
cord-307860-iqk1yiw4	109	17	,	,	,
cord-307860-iqk1yiw4	109	18	respectively	respectively	RB
cord-307860-iqk1yiw4	109	19	[	[	-LRB-
cord-307860-iqk1yiw4	109	20	59	59	CD
cord-307860-iqk1yiw4	109	21	]	]	-RRB-
cord-307860-iqk1yiw4	109	22	.	.	.
cord-307860-iqk1yiw4	110	1	Dai	Dai	NNP
cord-307860-iqk1yiw4	110	2	et	et	FW
cord-307860-iqk1yiw4	110	3	al	al	NNP
cord-307860-iqk1yiw4	110	4	.	.	.
cord-307860-iqk1yiw4	111	1	published	publish	VBD
cord-307860-iqk1yiw4	111	2	the	the	DT
cord-307860-iqk1yiw4	111	3	compounds	compound	NNS
cord-307860-iqk1yiw4	111	4	11b	11b	NNS
cord-307860-iqk1yiw4	111	5	that	that	WDT
cord-307860-iqk1yiw4	111	6	showed	show	VBD
cord-307860-iqk1yiw4	111	7	EC50	EC50	NNP
cord-307860-iqk1yiw4	111	8	of	of	IN
cord-307860-iqk1yiw4	111	9	0.72	0.72	CD
cord-307860-iqk1yiw4	111	10	μM	μm	CD
cord-307860-iqk1yiw4	111	11	,	,	,
cord-307860-iqk1yiw4	111	12	identical	identical	JJ
cord-307860-iqk1yiw4	111	13	to	to	IN
cord-307860-iqk1yiw4	111	14	the	the	DT
cord-307860-iqk1yiw4	111	15	EC50	EC50	NNP
cord-307860-iqk1yiw4	111	16	of	of	IN
cord-307860-iqk1yiw4	111	17	remdesivir	remdesivir	NNP
cord-307860-iqk1yiw4	111	18	(	(	-LRB-
cord-307860-iqk1yiw4	111	19	Table	table	NN
cord-307860-iqk1yiw4	111	20	1	1	CD
cord-307860-iqk1yiw4	111	21	)	)	-RRB-
cord-307860-iqk1yiw4	111	22	[	[	-LRB-
cord-307860-iqk1yiw4	111	23	42	42	CD
cord-307860-iqk1yiw4	111	24	]	]	-RRB-
cord-307860-iqk1yiw4	111	25	.	.	.
cord-307860-iqk1yiw4	112	1	Compounds	compound	NNS
cord-307860-iqk1yiw4	112	2	11a	11a	NNS
cord-307860-iqk1yiw4	112	3	and	and	CC
cord-307860-iqk1yiw4	112	4	11b	11b	NNS
cord-307860-iqk1yiw4	113	1	(	(	-LRB-
cord-307860-iqk1yiw4	113	2	PDB	PDB	NNP
cord-307860-iqk1yiw4	113	3	ID(s	ID(s	NNP
cord-307860-iqk1yiw4	113	4	)	)	-RRB-
cord-307860-iqk1yiw4	113	5	6LZE	6lze	CD
cord-307860-iqk1yiw4	113	6	and	and	CC
cord-307860-iqk1yiw4	113	7	6M0	6m0	CD
cord-307860-iqk1yiw4	113	8	K	K	NNP
cord-307860-iqk1yiw4	113	9	)	)	-RRB-
cord-307860-iqk1yiw4	113	10	show	show	VBP
cord-307860-iqk1yiw4	113	11	good	good	JJ
cord-307860-iqk1yiw4	113	12	inhibitory	inhibitory	JJ
cord-307860-iqk1yiw4	113	13	activity	activity	NN
cord-307860-iqk1yiw4	113	14	at	at	IN
cord-307860-iqk1yiw4	113	15	a	a	DT
cord-307860-iqk1yiw4	113	16	concentration	concentration	NN
cord-307860-iqk1yiw4	113	17	of	of	IN
cord-307860-iqk1yiw4	113	18	1	1	CD
cord-307860-iqk1yiw4	113	19	μM-100	μM-100	NNPS
cord-307860-iqk1yiw4	113	20	%	%	NN
cord-307860-iqk1yiw4	113	21	and	and	CC
cord-307860-iqk1yiw4	113	22	96	96	CD
cord-307860-iqk1yiw4	113	23	%	%	NN
cord-307860-iqk1yiw4	113	24	,	,	,
cord-307860-iqk1yiw4	113	25	respectively	respectively	RB
cord-307860-iqk1yiw4	113	26	[	[	-LRB-
cord-307860-iqk1yiw4	113	27	42	42	CD
cord-307860-iqk1yiw4	113	28	]	]	-RRB-
cord-307860-iqk1yiw4	113	29	.	.	.
cord-307860-iqk1yiw4	114	1	Zhang	Zhang	NNP
cord-307860-iqk1yiw4	114	2	et	et	NNP
cord-307860-iqk1yiw4	114	3	al	al	NNP
cord-307860-iqk1yiw4	114	4	.	.	.
cord-307860-iqk1yiw4	115	1	published	publish	VBN
cord-307860-iqk1yiw4	115	2	three	three	CD
cord-307860-iqk1yiw4	115	3	SARS	SARS	NNP
cord-307860-iqk1yiw4	115	4	-	-	HYPH
cord-307860-iqk1yiw4	115	5	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	115	6	3CL	3cl	CD
cord-307860-iqk1yiw4	115	7	pro	pro	VBP
cord-307860-iqk1yiw4	115	8	-one	-one	JJ
cord-307860-iqk1yiw4	115	9	free	free	JJ
cord-307860-iqk1yiw4	115	10	enzyme	enzyme	NN
cord-307860-iqk1yiw4	115	11	(	(	-LRB-
cord-307860-iqk1yiw4	115	12	PDB	PDB	NNP
cord-307860-iqk1yiw4	115	13	ID	ID	NNP
cord-307860-iqk1yiw4	115	14	6Y2E	6y2e	CD
cord-307860-iqk1yiw4	115	15	)	)	-RRB-
cord-307860-iqk1yiw4	115	16	and	and	CC
cord-307860-iqk1yiw4	115	17	two	two	CD
cord-307860-iqk1yiw4	115	18	crystal	crystal	NN
cord-307860-iqk1yiw4	115	19	structures	structure	NNS
cord-307860-iqk1yiw4	115	20	with	with	IN
cord-307860-iqk1yiw4	115	21	a	a	DT
cord-307860-iqk1yiw4	115	22	new	new	JJ
cord-307860-iqk1yiw4	115	23	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	115	24	candidate	candidate	NN
cord-307860-iqk1yiw4	115	25	-	-	:
cord-307860-iqk1yiw4	115	26	an	an	DT
cord-307860-iqk1yiw4	115	27	alpha	alpha	NN
cord-307860-iqk1yiw4	115	28	-	-	HYPH
cord-307860-iqk1yiw4	115	29	ketoamide	ketoamide	JJ
cord-307860-iqk1yiw4	115	30	compound	compound	NN
cord-307860-iqk1yiw4	115	31	13b	13b	NNS
cord-307860-iqk1yiw4	115	32	(	(	-LRB-
cord-307860-iqk1yiw4	115	33	PDB	PDB	NNP
cord-307860-iqk1yiw4	115	34	ID(s	ID(s	NNP
cord-307860-iqk1yiw4	115	35	)	)	-RRB-
cord-307860-iqk1yiw4	115	36	6Y2	6y2	CD
cord-307860-iqk1yiw4	115	37	G	g	NN
cord-307860-iqk1yiw4	115	38	and	and	CC
cord-307860-iqk1yiw4	115	39	6Y2F	6y2f	CD
cord-307860-iqk1yiw4	115	40	)	)	-RRB-
cord-307860-iqk1yiw4	115	41	[	[	-LRB-
cord-307860-iqk1yiw4	115	42	44	44	CD
cord-307860-iqk1yiw4	115	43	]	]	-RRB-
cord-307860-iqk1yiw4	115	44	.	.	.
cord-307860-iqk1yiw4	116	1	Compound	compound	NN
cord-307860-iqk1yiw4	116	2	13b	13b	CD
cord-307860-iqk1yiw4	116	3	is	be	VBZ
cord-307860-iqk1yiw4	116	4	a	a	DT
cord-307860-iqk1yiw4	116	5	non	non	JJ
cord-307860-iqk1yiw4	116	6	-	-	JJ
cord-307860-iqk1yiw4	116	7	polymer	polymer	JJ
cord-307860-iqk1yiw4	116	8	compound	compound	NN
cord-307860-iqk1yiw4	116	9	derived	derive	VBN
cord-307860-iqk1yiw4	116	10	from	from	IN
cord-307860-iqk1yiw4	116	11	a	a	DT
cord-307860-iqk1yiw4	116	12	peptidomimetic	peptidomimetic	JJ
cord-307860-iqk1yiw4	116	13	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	116	14	against	against	IN
cord-307860-iqk1yiw4	116	15	enterovirus	enterovirus	NN
cord-307860-iqk1yiw4	116	16	proteases	protease	NNS
cord-307860-iqk1yiw4	116	17	[	[	-LRB-
cord-307860-iqk1yiw4	116	18	60	60	CD
cord-307860-iqk1yiw4	116	19	]	]	-RRB-
cord-307860-iqk1yiw4	116	20	.	.	.
cord-307860-iqk1yiw4	117	1	The	the	DT
cord-307860-iqk1yiw4	117	2	X	x	NN
cord-307860-iqk1yiw4	117	3	-	-	NN
cord-307860-iqk1yiw4	117	4	ray	ray	NN
cord-307860-iqk1yiw4	117	5	crystal	crystal	NN
cord-307860-iqk1yiw4	117	6	structures	structure	NNS
cord-307860-iqk1yiw4	117	7	of	of	IN
cord-307860-iqk1yiw4	117	8	the	the	DT
cord-307860-iqk1yiw4	117	9	SARS	SARS	NNP
cord-307860-iqk1yiw4	117	10	-	-	HYPH
cord-307860-iqk1yiw4	117	11	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	117	12	3CL	3cl	CD
cord-307860-iqk1yiw4	117	13	pro	pro	JJ
cord-307860-iqk1yiw4	117	14	co	co	NN
cord-307860-iqk1yiw4	117	15	-	-	JJ
cord-307860-iqk1yiw4	117	16	crystallized	crystallize	VBN
cord-307860-iqk1yiw4	117	17	with	with	IN
cord-307860-iqk1yiw4	117	18	13b	13b	NNS
cord-307860-iqk1yiw4	117	19	demonstrated	demonstrate	VBD
cord-307860-iqk1yiw4	117	20	that	that	IN
cord-307860-iqk1yiw4	117	21	the	the	DT
cord-307860-iqk1yiw4	117	22	interactions	interaction	NNS
cord-307860-iqk1yiw4	117	23	from	from	IN
cord-307860-iqk1yiw4	117	24	the	the	DT
cord-307860-iqk1yiw4	117	25	dimer	dimer	NN
cord-307860-iqk1yiw4	117	26	interface	interface	NN
cord-307860-iqk1yiw4	117	27	are	be	VBP
cord-307860-iqk1yiw4	117	28	essential	essential	JJ
cord-307860-iqk1yiw4	117	29	for	for	IN
cord-307860-iqk1yiw4	117	30	shaping	shape	VBG
cord-307860-iqk1yiw4	117	31	the	the	DT
cord-307860-iqk1yiw4	117	32	binding	bind	VBG
cord-307860-iqk1yiw4	117	33	pocket	pocket	NN
cord-307860-iqk1yiw4	117	34	.	.	.
cord-307860-iqk1yiw4	118	1	Also	also	RB
cord-307860-iqk1yiw4	118	2	,	,	,
cord-307860-iqk1yiw4	118	3	the	the	DT
cord-307860-iqk1yiw4	118	4	authors	author	NNS
cord-307860-iqk1yiw4	118	5	greatly	greatly	RB
cord-307860-iqk1yiw4	118	6	improved	improve	VBD
cord-307860-iqk1yiw4	118	7	the	the	DT
cord-307860-iqk1yiw4	118	8	pharmacokinetic	pharmacokinetic	JJ
cord-307860-iqk1yiw4	118	9	characteristics	characteristic	NNS
cord-307860-iqk1yiw4	118	10	of	of	IN
cord-307860-iqk1yiw4	118	11	the	the	DT
cord-307860-iqk1yiw4	118	12	compound	compound	NN
cord-307860-iqk1yiw4	118	13	13b	13b	NNS
cord-307860-iqk1yiw4	118	14	.	.	.
cord-307860-iqk1yiw4	119	1	The	the	DT
cord-307860-iqk1yiw4	119	2	compound	compound	NN
cord-307860-iqk1yiw4	119	3	13b	13b	NNS
cord-307860-iqk1yiw4	119	4	can	can	MD
cord-307860-iqk1yiw4	119	5	be	be	VB
cord-307860-iqk1yiw4	119	6	administered	administer	VBN
cord-307860-iqk1yiw4	119	7	as	as	IN
cord-307860-iqk1yiw4	119	8	an	an	DT
cord-307860-iqk1yiw4	119	9	inhaler	inhaler	NN
cord-307860-iqk1yiw4	119	10	[	[	-LRB-
cord-307860-iqk1yiw4	119	11	44	44	CD
cord-307860-iqk1yiw4	119	12	]	]	-RRB-
cord-307860-iqk1yiw4	119	13	.	.	.
cord-307860-iqk1yiw4	120	1	Two	two	CD
cord-307860-iqk1yiw4	120	2	X	x	NN
cord-307860-iqk1yiw4	120	3	-	-	NN
cord-307860-iqk1yiw4	120	4	ray	ray	NN
cord-307860-iqk1yiw4	120	5	crystal	crystal	NN
cord-307860-iqk1yiw4	120	6	structures	structure	NNS
cord-307860-iqk1yiw4	120	7	of	of	IN
cord-307860-iqk1yiw4	120	8	the	the	DT
cord-307860-iqk1yiw4	120	9	SARS	SARS	NNP
cord-307860-iqk1yiw4	120	10	-	-	HYPH
cord-307860-iqk1yiw4	120	11	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	120	12	3CL	3cl	CD
cord-307860-iqk1yiw4	120	13	pro	pro	JJ
cord-307860-iqk1yiw4	120	14	co	co	NN
cord-307860-iqk1yiw4	120	15	-	-	JJ
cord-307860-iqk1yiw4	120	16	crystallized	crystallize	VBN
cord-307860-iqk1yiw4	120	17	with	with	IN
cord-307860-iqk1yiw4	120	18	Michael	Michael	NNP
cord-307860-iqk1yiw4	120	19	acceptor	acceptor	NN
cord-307860-iqk1yiw4	120	20	-	-	HYPH
cord-307860-iqk1yiw4	120	21	based	base	VBN
cord-307860-iqk1yiw4	120	22	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	120	23	(	(	-LRB-
cord-307860-iqk1yiw4	120	24	PRD_002214	prd_002214	NN
cord-307860-iqk1yiw4	120	25	)	)	-RRB-
cord-307860-iqk1yiw4	120	26	were	be	VBD
cord-307860-iqk1yiw4	120	27	recently	recently	RB
cord-307860-iqk1yiw4	120	28	published	publish	VBN
cord-307860-iqk1yiw4	120	29	:	:	:
cord-307860-iqk1yiw4	120	30	PDB	PDB	NNP
cord-307860-iqk1yiw4	120	31	ID(s	ID(s	NNP
cord-307860-iqk1yiw4	120	32	)	)	-RRB-
cord-307860-iqk1yiw4	120	33	6LU7	6lu7	CD
cord-307860-iqk1yiw4	121	1	and	and	CC
cord-307860-iqk1yiw4	121	2	7BQY	7BQY	NNP
cord-307860-iqk1yiw4	121	3	.	.	.
cord-307860-iqk1yiw4	122	1	The	the	DT
cord-307860-iqk1yiw4	122	2	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	122	3	PRD_002214	prd_002214	NN
cord-307860-iqk1yiw4	122	4	,	,	,
cord-307860-iqk1yiw4	122	5	the	the	DT
cord-307860-iqk1yiw4	122	6	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	122	7	N3	n3	NN
cord-307860-iqk1yiw4	122	8	,	,	,
cord-307860-iqk1yiw4	122	9	is	be	VBZ
cord-307860-iqk1yiw4	122	10	the	the	DT
cord-307860-iqk1yiw4	122	11	result	result	NN
cord-307860-iqk1yiw4	122	12	of	of	IN
cord-307860-iqk1yiw4	122	13	the	the	DT
cord-307860-iqk1yiw4	122	14	high	high	JJ
cord-307860-iqk1yiw4	122	15	-	-	HYPH
cord-307860-iqk1yiw4	122	16	throughput	throughput	NN
cord-307860-iqk1yiw4	122	17	screening	screening	NN
cord-307860-iqk1yiw4	122	18	of	of	IN
cord-307860-iqk1yiw4	122	19	more	more	JJR
cord-307860-iqk1yiw4	122	20	10,000	10,000	CD
cord-307860-iqk1yiw4	122	21	inhibitory	inhibitory	JJ
cord-307860-iqk1yiw4	122	22	compounds	compound	NNS
cord-307860-iqk1yiw4	122	23	against	against	IN
cord-307860-iqk1yiw4	122	24	SARS	SARS	NNP
cord-307860-iqk1yiw4	122	25	-	-	HYPH
cord-307860-iqk1yiw4	122	26	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	122	27	3CL	3CL	NNP
cord-307860-iqk1yiw4	122	28	pro	pro	JJ
cord-307860-iqk1yiw4	122	29	.	.	.
cord-307860-iqk1yiw4	123	1	The	the	DT
cord-307860-iqk1yiw4	123	2	kinetic	kinetic	JJ
cord-307860-iqk1yiw4	123	3	experiments	experiment	NNS
cord-307860-iqk1yiw4	123	4	showed	show	VBD
cord-307860-iqk1yiw4	123	5	that	that	IN
cord-307860-iqk1yiw4	123	6	N3	n3	NN
cord-307860-iqk1yiw4	123	7	is	be	VBZ
cord-307860-iqk1yiw4	123	8	a	a	DT
cord-307860-iqk1yiw4	123	9	time	time	NN
cord-307860-iqk1yiw4	123	10	-	-	HYPH
cord-307860-iqk1yiw4	123	11	dependent	dependent	JJ
cord-307860-iqk1yiw4	123	12	irreversible	irreversible	JJ
cord-307860-iqk1yiw4	123	13	peptide	peptide	NN
cord-307860-iqk1yiw4	123	14	-	-	HYPH
cord-307860-iqk1yiw4	123	15	like	like	JJ
cord-307860-iqk1yiw4	123	16	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	123	17	of	of	IN
cord-307860-iqk1yiw4	123	18	the	the	DT
cord-307860-iqk1yiw4	123	19	SARS	SARS	NNP
cord-307860-iqk1yiw4	123	20	-	-	HYPH
cord-307860-iqk1yiw4	123	21	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	123	22	3CL	3CL	NNP
cord-307860-iqk1yiw4	123	23	pro	pro	JJ
cord-307860-iqk1yiw4	123	24	.	.	.
cord-307860-iqk1yiw4	124	1	Molecular	molecular	JJ
cord-307860-iqk1yiw4	124	2	docking	docking	NN
cord-307860-iqk1yiw4	124	3	analysis	analysis	NN
cord-307860-iqk1yiw4	124	4	demonstrated	demonstrate	VBD
cord-307860-iqk1yiw4	124	5	that	that	IN
cord-307860-iqk1yiw4	124	6	N3	n3	NN
cord-307860-iqk1yiw4	124	7	fit	fit	NN
cord-307860-iqk1yiw4	124	8	inside	inside	IN
cord-307860-iqk1yiw4	124	9	the	the	DT
cord-307860-iqk1yiw4	124	10	substrate	substrate	NN
cord-307860-iqk1yiw4	124	11	-	-	HYPH
cord-307860-iqk1yiw4	124	12	binding	bind	VBG
cord-307860-iqk1yiw4	124	13	pocket	pocket	NN
cord-307860-iqk1yiw4	124	14	(	(	-LRB-
cord-307860-iqk1yiw4	124	15	Cys145-His41	Cys145-His41	NNP
cord-307860-iqk1yiw4	124	16	catalytic	catalytic	JJ
cord-307860-iqk1yiw4	124	17	dyad	dyad	NNP
cord-307860-iqk1yiw4	124	18	)	)	-RRB-
cord-307860-iqk1yiw4	124	19	highly	highly	RB
cord-307860-iqk1yiw4	124	20	conserved	conserve	VBN
cord-307860-iqk1yiw4	124	21	in	in	IN
cord-307860-iqk1yiw4	124	22	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	124	23	[	[	-LRB-
cord-307860-iqk1yiw4	124	24	41	41	CD
cord-307860-iqk1yiw4	124	25	,	,	,
cord-307860-iqk1yiw4	124	26	61	61	CD
cord-307860-iqk1yiw4	124	27	]	]	-RRB-
cord-307860-iqk1yiw4	124	28	.	.	.
cord-307860-iqk1yiw4	125	1	A	a	DT
cord-307860-iqk1yiw4	125	2	recent	recent	JJ
cord-307860-iqk1yiw4	125	3	structural	structural	JJ
cord-307860-iqk1yiw4	125	4	study	study	NN
cord-307860-iqk1yiw4	125	5	hypothesized	hypothesize	VBD
cord-307860-iqk1yiw4	125	6	that	that	IN
cord-307860-iqk1yiw4	125	7	a	a	DT
cord-307860-iqk1yiw4	125	8	cluster	cluster	NN
cord-307860-iqk1yiw4	125	9	of	of	IN
cord-307860-iqk1yiw4	125	10	residues	residue	NNS
cord-307860-iqk1yiw4	125	11	outside	outside	IN
cord-307860-iqk1yiw4	125	12	the	the	DT
cord-307860-iqk1yiw4	125	13	catalytic	catalytic	JJ
cord-307860-iqk1yiw4	125	14	site	site	NN
cord-307860-iqk1yiw4	125	15	are	be	VBP
cord-307860-iqk1yiw4	125	16	possibly	possibly	RB
cord-307860-iqk1yiw4	125	17	conformationally	conformationally	RB
cord-307860-iqk1yiw4	125	18	relevant	relevant	JJ
cord-307860-iqk1yiw4	125	19	when	when	WRB
cord-307860-iqk1yiw4	125	20	bound	bind	VBN
cord-307860-iqk1yiw4	125	21	to	to	IN
cord-307860-iqk1yiw4	125	22	the	the	DT
cord-307860-iqk1yiw4	125	23	N3	n3	NN
cord-307860-iqk1yiw4	125	24	[	[	-LRB-
cord-307860-iqk1yiw4	125	25	62	62	CD
cord-307860-iqk1yiw4	125	26	]	]	-RRB-
cord-307860-iqk1yiw4	125	27	.	.	.
cord-307860-iqk1yiw4	126	1	The	the	DT
cord-307860-iqk1yiw4	126	2	inhibition	inhibition	NN
cord-307860-iqk1yiw4	126	3	of	of	IN
cord-307860-iqk1yiw4	126	4	hydrolytic	hydrolytic	JJ
cord-307860-iqk1yiw4	126	5	activity	activity	NN
cord-307860-iqk1yiw4	126	6	of	of	IN
cord-307860-iqk1yiw4	126	7	the	the	DT
cord-307860-iqk1yiw4	126	8	N3	n3	NN
cord-307860-iqk1yiw4	126	9	was	be	VBD
cord-307860-iqk1yiw4	126	10	previously	previously	RB
cord-307860-iqk1yiw4	126	11	determined	determine	VBN
cord-307860-iqk1yiw4	126	12	for	for	IN
cord-307860-iqk1yiw4	126	13	other	other	JJ
cord-307860-iqk1yiw4	126	14	CoVs	covs	NN
cord-307860-iqk1yiw4	126	15	(	(	-LRB-
cord-307860-iqk1yiw4	126	16	HCoV-22E	HCoV-22E	NNP
cord-307860-iqk1yiw4	126	17	,	,	,
cord-307860-iqk1yiw4	126	18	FIPV	FIPV	NNP
cord-307860-iqk1yiw4	126	19	,	,	,
cord-307860-iqk1yiw4	126	20	and	and	CC
cord-307860-iqk1yiw4	126	21	MHV	MHV	NNP
cord-307860-iqk1yiw4	126	22	-	-	HYPH
cord-307860-iqk1yiw4	126	23	A59	A59	NNP
cord-307860-iqk1yiw4	126	24	)	)	-RRB-
cord-307860-iqk1yiw4	127	1	(	(	-LRB-
cord-307860-iqk1yiw4	127	2	Table	table	NN
cord-307860-iqk1yiw4	127	3	1	1	CD
cord-307860-iqk1yiw4	127	4	)	)	-RRB-
cord-307860-iqk1yiw4	127	5	.	.	.
cord-307860-iqk1yiw4	128	1	The	the	DT
cord-307860-iqk1yiw4	128	2	overall	overall	JJ
cord-307860-iqk1yiw4	128	3	analysis	analysis	NN
cord-307860-iqk1yiw4	128	4	of	of	IN
cord-307860-iqk1yiw4	128	5	the	the	DT
cord-307860-iqk1yiw4	128	6	available	available	JJ
cord-307860-iqk1yiw4	128	7	data	data	NN
cord-307860-iqk1yiw4	128	8	suggests	suggest	VBZ
cord-307860-iqk1yiw4	128	9	that	that	IN
cord-307860-iqk1yiw4	128	10	N3	n3	NN
cord-307860-iqk1yiw4	128	11	is	be	VBZ
cord-307860-iqk1yiw4	128	12	a	a	DT
cord-307860-iqk1yiw4	128	13	wide	wide	JJ
cord-307860-iqk1yiw4	128	14	-	-	HYPH
cord-307860-iqk1yiw4	128	15	spectrum	spectrum	NN
cord-307860-iqk1yiw4	128	16	anti	anti	JJ
cord-307860-iqk1yiw4	128	17	-	-	JJ
cord-307860-iqk1yiw4	128	18	CoV	cov	JJ
cord-307860-iqk1yiw4	128	19	lead	lead	NN
cord-307860-iqk1yiw4	128	20	compound	compound	NNP
cord-307860-iqk1yiw4	128	21	[	[	-LRB-
cord-307860-iqk1yiw4	128	22	63	63	CD
cord-307860-iqk1yiw4	128	23	]	]	-RRB-
cord-307860-iqk1yiw4	128	24	.	.	.
cord-307860-iqk1yiw4	129	1	Another	another	DT
cord-307860-iqk1yiw4	129	2	structural	structural	JJ
cord-307860-iqk1yiw4	129	3	study	study	NN
cord-307860-iqk1yiw4	129	4	demonstrated	demonstrate	VBD
cord-307860-iqk1yiw4	129	5	that	that	IN
cord-307860-iqk1yiw4	129	6	the	the	DT
cord-307860-iqk1yiw4	129	7	antineoplastic	antineoplastic	JJ
cord-307860-iqk1yiw4	129	8	drug	drug	NN
cord-307860-iqk1yiw4	129	9	carmofur	carmofur	NNP
cord-307860-iqk1yiw4	129	10	inhibits	inhibit	VBZ
cord-307860-iqk1yiw4	129	11	the	the	DT
cord-307860-iqk1yiw4	129	12	3CL	3cl	CD
cord-307860-iqk1yiw4	129	13	pro	pro	JJ
cord-307860-iqk1yiw4	129	14	SARS	SARS	NNP
cord-307860-iqk1yiw4	129	15	-	-	HYPH
cord-307860-iqk1yiw4	129	16	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	129	17	(	(	-LRB-
cord-307860-iqk1yiw4	129	18	PDB	PDB	NNP
cord-307860-iqk1yiw4	129	19	ID	ID	NNP
cord-307860-iqk1yiw4	129	20	7BUY	7BUY	NNP
cord-307860-iqk1yiw4	129	21	)	)	-RRB-
cord-307860-iqk1yiw4	129	22	.	.	.
cord-307860-iqk1yiw4	130	1	Carmofur	Carmofur	NNP
cord-307860-iqk1yiw4	130	2	(	(	-LRB-
cord-307860-iqk1yiw4	130	3	PubChem	PubChem	NNP
cord-307860-iqk1yiw4	130	4	CID	CID	NNP
cord-307860-iqk1yiw4	130	5	2577	2577	CD
cord-307860-iqk1yiw4	130	6	)	)	-RRB-
cord-307860-iqk1yiw4	131	1	(	(	-LRB-
cord-307860-iqk1yiw4	131	2	C	c	NN
cord-307860-iqk1yiw4	131	3	11	11	CD
cord-307860-iqk1yiw4	131	4	H	H	NNP
cord-307860-iqk1yiw4	131	5	16	16	CD
cord-307860-iqk1yiw4	131	6	FN	FN	NNP
cord-307860-iqk1yiw4	131	7	3	3	CD
cord-307860-iqk1yiw4	131	8	O	o	NN
cord-307860-iqk1yiw4	131	9	3	3	CD
cord-307860-iqk1yiw4	131	10	)	)	-RRB-
cord-307860-iqk1yiw4	131	11	is	be	VBZ
cord-307860-iqk1yiw4	131	12	an	an	DT
cord-307860-iqk1yiw4	131	13	antimetabolite	antimetabolite	JJ
cord-307860-iqk1yiw4	131	14	(	(	-LRB-
cord-307860-iqk1yiw4	131	15	pyrimidine	pyrimidine	NNP
cord-307860-iqk1yiw4	131	16	analog	analog	NN
cord-307860-iqk1yiw4	131	17	)	)	-RRB-
cord-307860-iqk1yiw4	131	18	derivative	derivative	NN
cord-307860-iqk1yiw4	131	19	of	of	IN
cord-307860-iqk1yiw4	131	20	5′-fluorouracil	5′-fluorouracil	CD
cord-307860-iqk1yiw4	131	21	.	.	.
cord-307860-iqk1yiw4	132	1	Carmofur	Carmofur	NNP
cord-307860-iqk1yiw4	132	2	is	be	VBZ
cord-307860-iqk1yiw4	132	3	used	use	VBN
cord-307860-iqk1yiw4	132	4	to	to	TO
cord-307860-iqk1yiw4	132	5	treat	treat	VB
cord-307860-iqk1yiw4	132	6	colorectal	colorectal	JJ
cord-307860-iqk1yiw4	132	7	cancer	cancer	NN
cord-307860-iqk1yiw4	132	8	and	and	CC
cord-307860-iqk1yiw4	132	9	breast	breast	NN
cord-307860-iqk1yiw4	132	10	cancer	cancer	NN
cord-307860-iqk1yiw4	132	11	(	(	-LRB-
cord-307860-iqk1yiw4	132	12	DrugBank	DrugBank	NNP
cord-307860-iqk1yiw4	132	13	DB09010	DB09010	NNP
cord-307860-iqk1yiw4	132	14	)	)	-RRB-
cord-307860-iqk1yiw4	132	15	.	.	.
cord-307860-iqk1yiw4	133	1	The	the	DT
cord-307860-iqk1yiw4	133	2	Jin	Jin	NNP
cord-307860-iqk1yiw4	133	3	et	et	FW
cord-307860-iqk1yiw4	133	4	al	al	NNP
cord-307860-iqk1yiw4	133	5	.	.	.
cord-307860-iqk1yiw4	134	1	study	study	NN
cord-307860-iqk1yiw4	134	2	shows	show	VBZ
cord-307860-iqk1yiw4	134	3	that	that	IN
cord-307860-iqk1yiw4	134	4	carmofur	carmofur	NNP
cord-307860-iqk1yiw4	134	5	inhibits	inhibit	VBZ
cord-307860-iqk1yiw4	134	6	viral	viral	JJ
cord-307860-iqk1yiw4	134	7	replication	replication	NN
cord-307860-iqk1yiw4	134	8	by	by	IN
cord-307860-iqk1yiw4	134	9	forming	form	VBG
cord-307860-iqk1yiw4	134	10	a	a	DT
cord-307860-iqk1yiw4	134	11	covalent	covalent	JJ
cord-307860-iqk1yiw4	134	12	bond	bond	NN
cord-307860-iqk1yiw4	134	13	with	with	IN
cord-307860-iqk1yiw4	134	14	the	the	DT
cord-307860-iqk1yiw4	134	15	cysteine	cysteine	NN
cord-307860-iqk1yiw4	134	16	residue	residue	NN
cord-307860-iqk1yiw4	134	17	from	from	IN
cord-307860-iqk1yiw4	134	18	the	the	DT
cord-307860-iqk1yiw4	134	19	catalytic	catalytic	JJ
cord-307860-iqk1yiw4	134	20	site	site	NN
cord-307860-iqk1yiw4	134	21	of	of	IN
cord-307860-iqk1yiw4	134	22	the	the	DT
cord-307860-iqk1yiw4	134	23	3CL	3cl	CD
cord-307860-iqk1yiw4	134	24	pro	pro	JJ
cord-307860-iqk1yiw4	134	25	SARS	SARS	NNP
cord-307860-iqk1yiw4	134	26	-	-	HYPH
cord-307860-iqk1yiw4	134	27	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	134	28	(	(	-LRB-
cord-307860-iqk1yiw4	134	29	Table	table	NN
cord-307860-iqk1yiw4	134	30	1	1	CD
cord-307860-iqk1yiw4	134	31	)	)	-RRB-
cord-307860-iqk1yiw4	135	1	[	[	-LRB-
cord-307860-iqk1yiw4	135	2	64	64	CD
cord-307860-iqk1yiw4	135	3	]	]	-RRB-
cord-307860-iqk1yiw4	135	4	.	.	.
cord-307860-iqk1yiw4	136	1	The	the	DT
cord-307860-iqk1yiw4	136	2	3CL	3cl	CD
cord-307860-iqk1yiw4	136	3	pro	pro	NN
cord-307860-iqk1yiw4	136	4	is	be	VBZ
cord-307860-iqk1yiw4	136	5	a	a	DT
cord-307860-iqk1yiw4	136	6	particular	particular	JJ
cord-307860-iqk1yiw4	136	7	cysteine	cysteine	NN
cord-307860-iqk1yiw4	136	8	protease	protease	NN
cord-307860-iqk1yiw4	136	9	that	that	WDT
cord-307860-iqk1yiw4	136	10	comprises	comprise	VBZ
cord-307860-iqk1yiw4	136	11	three	three	CD
cord-307860-iqk1yiw4	136	12	domains	domain	NNS
cord-307860-iqk1yiw4	136	13	.	.	.
cord-307860-iqk1yiw4	137	1	The	the	DT
cord-307860-iqk1yiw4	137	2	3CL	3cl	CD
cord-307860-iqk1yiw4	137	3	pro	pro	JJ
cord-307860-iqk1yiw4	137	4	proteolytic	proteolytic	JJ
cord-307860-iqk1yiw4	137	5	activity	activity	NN
cord-307860-iqk1yiw4	137	6	requires	require	VBZ
cord-307860-iqk1yiw4	137	7	the	the	DT
cord-307860-iqk1yiw4	137	8	formation	formation	NN
cord-307860-iqk1yiw4	137	9	of	of	IN
cord-307860-iqk1yiw4	137	10	the	the	DT
cord-307860-iqk1yiw4	137	11	Cys(−)/His(+	Cys(−)/His(+	.
cord-307860-iqk1yiw4	137	12	)	)	-RRB-
cord-307860-iqk1yiw4	138	1	zwitterionic	zwitterionic	NNP
cord-307860-iqk1yiw4	138	2	Table	Table	NNP
cord-307860-iqk1yiw4	138	3	1	1	CD
cord-307860-iqk1yiw4	139	1	The	the	DT
cord-307860-iqk1yiw4	139	2	comparison	comparison	NN
cord-307860-iqk1yiw4	139	3	of	of	IN
cord-307860-iqk1yiw4	139	4	the	the	DT
cord-307860-iqk1yiw4	139	5	antiviral	antiviral	JJ
cord-307860-iqk1yiw4	139	6	drug	drug	NN
cord-307860-iqk1yiw4	139	7	candidates	candidate	NNS
cord-307860-iqk1yiw4	139	8	against	against	IN
cord-307860-iqk1yiw4	139	9	SARS	SARS	NNP
cord-307860-iqk1yiw4	139	10	-	-	HYPH
cord-307860-iqk1yiw4	139	11	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	139	12	and	and	CC
cord-307860-iqk1yiw4	139	13	other	other	JJ
cord-307860-iqk1yiw4	139	14	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	139	15	GRL-0617	GRL-0617	NNP
cord-307860-iqk1yiw4	139	16	is	be	VBZ
cord-307860-iqk1yiw4	139	17	naphthalene	naphthalene	NN
cord-307860-iqk1yiw4	139	18	-	-	HYPH
cord-307860-iqk1yiw4	139	19	based	base	VBN
cord-307860-iqk1yiw4	139	20	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	139	21	,	,	,
cord-307860-iqk1yiw4	139	22	CC	CC	NNP
cord-307860-iqk1yiw4	139	23	50	50	CD
cord-307860-iqk1yiw4	139	24	is	be	VBZ
cord-307860-iqk1yiw4	139	25	the	the	DT
cord-307860-iqk1yiw4	139	26	cytotoxic	cytotoxic	JJ
cord-307860-iqk1yiw4	139	27	concentration	concentration	NN
cord-307860-iqk1yiw4	139	28	of	of	IN
cord-307860-iqk1yiw4	139	29	the	the	DT
cord-307860-iqk1yiw4	139	30	extracts	extract	NNS
cord-307860-iqk1yiw4	139	31	to	to	TO
cord-307860-iqk1yiw4	139	32	cause	cause	VB
cord-307860-iqk1yiw4	139	33	death	death	NN
cord-307860-iqk1yiw4	139	34	to	to	IN
cord-307860-iqk1yiw4	139	35	50	50	CD
cord-307860-iqk1yiw4	139	36	%	%	NN
cord-307860-iqk1yiw4	139	37	of	of	IN
cord-307860-iqk1yiw4	139	38	viable	viable	JJ
cord-307860-iqk1yiw4	139	39	cells	cell	NNS
cord-307860-iqk1yiw4	139	40	in	in	IN
cord-307860-iqk1yiw4	139	41	the	the	DT
cord-307860-iqk1yiw4	139	42	host	host	NN
cord-307860-iqk1yiw4	139	43	;	;	:
cord-307860-iqk1yiw4	139	44	EC	EC	NNP
cord-307860-iqk1yiw4	139	45	50	50	CD
cord-307860-iqk1yiw4	139	46	is	be	VBZ
cord-307860-iqk1yiw4	139	47	half	half	RB
cord-307860-iqk1yiw4	139	48	maximal	maximal	JJ
cord-307860-iqk1yiw4	139	49	effective	effective	JJ
cord-307860-iqk1yiw4	139	50	concentration	concentration	NN
cord-307860-iqk1yiw4	139	51	;	;	:
cord-307860-iqk1yiw4	139	52	IC	IC	NNP
cord-307860-iqk1yiw4	139	53	50	50	CD
cord-307860-iqk1yiw4	139	54	is	be	VBZ
cord-307860-iqk1yiw4	139	55	half	half	RB
cord-307860-iqk1yiw4	139	56	maximal	maximal	JJ
cord-307860-iqk1yiw4	139	57	inhibitory	inhibitory	JJ
cord-307860-iqk1yiw4	139	58	concentration	concentration	NN
cord-307860-iqk1yiw4	139	59	,	,	,
cord-307860-iqk1yiw4	139	60	NA	NA	NNP
cord-307860-iqk1yiw4	139	61	not	not	RB
cord-307860-iqk1yiw4	139	62	available	available	JJ
cord-307860-iqk1yiw4	139	63	;	;	:
cord-307860-iqk1yiw4	139	64	SD	SD	NNP
cord-307860-iqk1yiw4	139	65	is	be	VBZ
cord-307860-iqk1yiw4	139	66	standard	standard	JJ
cord-307860-iqk1yiw4	139	67	deviation	deviation	NN
cord-307860-iqk1yiw4	139	68	,	,	.
cord-307860-iqk1yiw4	140	1	CI95	CI95	NNP
cord-307860-iqk1yiw4	140	2	confidence	confidence	NN
cord-307860-iqk1yiw4	140	3	interval	interval	NN
cord-307860-iqk1yiw4	140	4	95	95	CD
cord-307860-iqk1yiw4	140	5	%	%	NN
cord-307860-iqk1yiw4	140	6	state	state	NN
cord-307860-iqk1yiw4	140	7	onto	onto	IN
cord-307860-iqk1yiw4	140	8	the	the	DT
cord-307860-iqk1yiw4	140	9	catalytic	catalytic	JJ
cord-307860-iqk1yiw4	140	10	dyad	dyad	NN
cord-307860-iqk1yiw4	140	11	[	[	-LRB-
cord-307860-iqk1yiw4	140	12	65	65	CD
cord-307860-iqk1yiw4	140	13	,	,	,
cord-307860-iqk1yiw4	140	14	66	66	CD
cord-307860-iqk1yiw4	140	15	]	]	-RRB-
cord-307860-iqk1yiw4	140	16	.	.	.
cord-307860-iqk1yiw4	141	1	Although	although	IN
cord-307860-iqk1yiw4	141	2	the	the	DT
cord-307860-iqk1yiw4	141	3	catalytic	catalytic	JJ
cord-307860-iqk1yiw4	141	4	mechanism	mechanism	NN
cord-307860-iqk1yiw4	141	5	of	of	IN
cord-307860-iqk1yiw4	141	6	CoV	CoV	NNP
cord-307860-iqk1yiw4	141	7	3CL	3CL	NNP
cord-307860-iqk1yiw4	141	8	pro	pro	NNP
cord-307860-iqk1yiw4	141	9	is	be	VBZ
cord-307860-iqk1yiw4	141	10	not	not	RB
cord-307860-iqk1yiw4	141	11	fully	fully	RB
cord-307860-iqk1yiw4	141	12	understood	understand	VBN
cord-307860-iqk1yiw4	141	13	,	,	,
cord-307860-iqk1yiw4	141	14	extensive	extensive	JJ
cord-307860-iqk1yiw4	141	15	studies	study	NNS
cord-307860-iqk1yiw4	141	16	that	that	WDT
cord-307860-iqk1yiw4	141	17	connected	connect	VBD
cord-307860-iqk1yiw4	141	18	the	the	DT
cord-307860-iqk1yiw4	141	19	structural	structural	JJ
cord-307860-iqk1yiw4	141	20	,	,	,
cord-307860-iqk1yiw4	141	21	computational	computational	JJ
cord-307860-iqk1yiw4	141	22	,	,	,
cord-307860-iqk1yiw4	141	23	and	and	CC
cord-307860-iqk1yiw4	141	24	biochemical	biochemical	JJ
cord-307860-iqk1yiw4	141	25	approaches	approach	NNS
cord-307860-iqk1yiw4	141	26	of	of	IN
cord-307860-iqk1yiw4	141	27	different	different	JJ
cord-307860-iqk1yiw4	141	28	wildtype	wildtype	NN
cord-307860-iqk1yiw4	141	29	and	and	CC
cord-307860-iqk1yiw4	141	30	mutated	mutate	VBN
cord-307860-iqk1yiw4	141	31	3CL	3cl	CD
cord-307860-iqk1yiw4	141	32	pro	pro	JJ
cord-307860-iqk1yiw4	141	33	decipher	decipher	JJ
cord-307860-iqk1yiw4	141	34	important	important	JJ
cord-307860-iqk1yiw4	141	35	aspects	aspect	NNS
cord-307860-iqk1yiw4	141	36	of	of	IN
cord-307860-iqk1yiw4	141	37	catalytic	catalytic	JJ
cord-307860-iqk1yiw4	141	38	efficiency	efficiency	NN
cord-307860-iqk1yiw4	141	39	[	[	-LRB-
cord-307860-iqk1yiw4	141	40	67	67	CD
cord-307860-iqk1yiw4	141	41	]	]	-RRB-
cord-307860-iqk1yiw4	141	42	.	.	.
cord-307860-iqk1yiw4	142	1	Thus	thus	RB
cord-307860-iqk1yiw4	142	2	,	,	,
cord-307860-iqk1yiw4	142	3	Wang	Wang	NNP
cord-307860-iqk1yiw4	142	4	et	et	NNP
cord-307860-iqk1yiw4	142	5	al	al	NNP
cord-307860-iqk1yiw4	142	6	.	.	.
cord-307860-iqk1yiw4	142	7	identify	identify	VB
cord-307860-iqk1yiw4	142	8	that	that	DT
cord-307860-iqk1yiw4	142	9	,	,	,
cord-307860-iqk1yiw4	142	10	besides	besides	IN
cord-307860-iqk1yiw4	142	11	the	the	DT
cord-307860-iqk1yiw4	142	12	cysteine	cysteine	NN
cord-307860-iqk1yiw4	142	13	from	from	IN
cord-307860-iqk1yiw4	142	14	the	the	DT
cord-307860-iqk1yiw4	142	15	catalytic	catalytic	JJ
cord-307860-iqk1yiw4	142	16	dyad	dyad	NN
cord-307860-iqk1yiw4	142	17	,	,	,
cord-307860-iqk1yiw4	142	18	the	the	DT
cord-307860-iqk1yiw4	142	19	3CL	3cl	CD
cord-307860-iqk1yiw4	142	20	pro	pro	JJ
cord-307860-iqk1yiw4	142	21	MERS	MERS	NNP
cord-307860-iqk1yiw4	142	22	-	-	HYPH
cord-307860-iqk1yiw4	142	23	CoV	CoV	NNP
cord-307860-iqk1yiw4	142	24	has	have	VBZ
cord-307860-iqk1yiw4	142	25	another	another	DT
cord-307860-iqk1yiw4	142	26	cysteine	cysteine	NN
cord-307860-iqk1yiw4	142	27	nearby	nearby	RB
cord-307860-iqk1yiw4	142	28	.	.	.
cord-307860-iqk1yiw4	143	1	The	the	DT
cord-307860-iqk1yiw4	143	2	role	role	NN
cord-307860-iqk1yiw4	143	3	of	of	IN
cord-307860-iqk1yiw4	143	4	the	the	DT
cord-307860-iqk1yiw4	143	5	second	second	JJ
cord-307860-iqk1yiw4	143	6	cysteine	cysteine	NN
cord-307860-iqk1yiw4	143	7	in	in	IN
cord-307860-iqk1yiw4	143	8	catalysis	catalysis	NN
cord-307860-iqk1yiw4	143	9	is	be	VBZ
cord-307860-iqk1yiw4	143	10	not	not	RB
cord-307860-iqk1yiw4	143	11	fully	fully	RB
cord-307860-iqk1yiw4	143	12	understood	understand	VBN
cord-307860-iqk1yiw4	143	13	.	.	.
cord-307860-iqk1yiw4	144	1	A	a	DT
cord-307860-iqk1yiw4	144	2	conserved	conserved	JJ
cord-307860-iqk1yiw4	144	3	motif	motif	NN
cord-307860-iqk1yiw4	144	4	GSCGS	GSCGS	NNP
cord-307860-iqk1yiw4	144	5	forms	form	VBZ
cord-307860-iqk1yiw4	144	6	consecutive	consecutive	JJ
cord-307860-iqk1yiw4	144	7	three	three	CD
cord-307860-iqk1yiw4	144	8	turns	turn	NNS
cord-307860-iqk1yiw4	144	9	when	when	WRB
cord-307860-iqk1yiw4	144	10	starting	start	VBG
cord-307860-iqk1yiw4	144	11	the	the	DT
cord-307860-iqk1yiw4	144	12	catalysis	catalysis	NN
cord-307860-iqk1yiw4	144	13	.	.	.
cord-307860-iqk1yiw4	145	1	Two	two	CD
cord-307860-iqk1yiw4	145	2	structural	structural	JJ
cord-307860-iqk1yiw4	145	3	characteristics	characteristic	NNS
cord-307860-iqk1yiw4	145	4	are	be	VBP
cord-307860-iqk1yiw4	145	5	essential	essential	JJ
cord-307860-iqk1yiw4	145	6	for	for	IN
cord-307860-iqk1yiw4	145	7	catalysis	catalysis	NN
cord-307860-iqk1yiw4	145	8	.	.	.
cord-307860-iqk1yiw4	146	1	The	the	DT
cord-307860-iqk1yiw4	146	2	first	first	JJ
cord-307860-iqk1yiw4	146	3	characteristic	characteristic	NN
cord-307860-iqk1yiw4	146	4	is	be	VBZ
cord-307860-iqk1yiw4	146	5	a	a	DT
cord-307860-iqk1yiw4	146	6	partial	partial	JJ
cord-307860-iqk1yiw4	146	7	negative	negative	JJ
cord-307860-iqk1yiw4	146	8	cluster	cluster	NN
cord-307860-iqk1yiw4	146	9	formed	form	VBN
cord-307860-iqk1yiw4	146	10	by	by	IN
cord-307860-iqk1yiw4	146	11	Arg	Arg	NNP
cord-307860-iqk1yiw4	146	12	-	-	HYPH
cord-307860-iqk1yiw4	146	13	Tyr	Tyr	NNP
cord-307860-iqk1yiw4	146	14	-	-	HYPH
cord-307860-iqk1yiw4	146	15	Asp	Asp	NNP
cord-307860-iqk1yiw4	146	16	.	.	.
cord-307860-iqk1yiw4	147	1	Secondly	secondly	RB
cord-307860-iqk1yiw4	147	2	,	,	,
cord-307860-iqk1yiw4	147	3	there	there	EX
cord-307860-iqk1yiw4	147	4	is	be	VBZ
cord-307860-iqk1yiw4	147	5	a	a	DT
cord-307860-iqk1yiw4	147	6	conserved	conserved	JJ
cord-307860-iqk1yiw4	147	7	water	water	NN
cord-307860-iqk1yiw4	147	8	molecule	molecule	NN
cord-307860-iqk1yiw4	147	9	that	that	WDT
cord-307860-iqk1yiw4	147	10	mediates	mediate	VBZ
cord-307860-iqk1yiw4	147	11	remote	remote	JJ
cord-307860-iqk1yiw4	147	12	control	control	NN
cord-307860-iqk1yiw4	147	13	between	between	IN
cord-307860-iqk1yiw4	147	14	the	the	DT
cord-307860-iqk1yiw4	147	15	partial	partial	JJ
cord-307860-iqk1yiw4	147	16	negative	negative	JJ
cord-307860-iqk1yiw4	147	17	charged	charge	VBN
cord-307860-iqk1yiw4	147	18	cluster	cluster	NN
cord-307860-iqk1yiw4	147	19	and	and	CC
cord-307860-iqk1yiw4	147	20	the	the	DT
cord-307860-iqk1yiw4	147	21	Cys	Cys	NNP
cord-307860-iqk1yiw4	147	22	-	-	HYPH
cord-307860-iqk1yiw4	147	23	His	-PRON-	PRP$
cord-307860-iqk1yiw4	147	24	dyad	dyad	NN
cord-307860-iqk1yiw4	147	25	.	.	.
cord-307860-iqk1yiw4	148	1	Also	also	RB
cord-307860-iqk1yiw4	148	2	,	,	,
cord-307860-iqk1yiw4	148	3	a	a	DT
cord-307860-iqk1yiw4	148	4	conserved	conserved	JJ
cord-307860-iqk1yiw4	148	5	pair	pair	NN
cord-307860-iqk1yiw4	148	6	(	(	-LRB-
cord-307860-iqk1yiw4	148	7	Glu	Glu	NNP
cord-307860-iqk1yiw4	148	8	-	-	HYPH
cord-307860-iqk1yiw4	148	9	His	His	NNP
cord-307860-iqk1yiw4	148	10	)	)	-RRB-
cord-307860-iqk1yiw4	148	11	very	very	RB
cord-307860-iqk1yiw4	148	12	well	well	RB
cord-307860-iqk1yiw4	148	13	conserved	conserve	VBN
cord-307860-iqk1yiw4	148	14	in	in	IN
cord-307860-iqk1yiw4	148	15	3CL	3cl	CD
cord-307860-iqk1yiw4	148	16	pro	pro	JJ
cord-307860-iqk1yiw4	148	17	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	148	18	forms	form	VBZ
cord-307860-iqk1yiw4	148	19	a	a	DT
cord-307860-iqk1yiw4	148	20	stable	stable	JJ
cord-307860-iqk1yiw4	148	21	hydrogen	hydrogen	NN
cord-307860-iqk1yiw4	148	22	-	-	HYPH
cord-307860-iqk1yiw4	148	23	bond	bond	NN
cord-307860-iqk1yiw4	148	24	.	.	.
cord-307860-iqk1yiw4	149	1	The	the	DT
cord-307860-iqk1yiw4	149	2	glutamine	glutamine	NN
cord-307860-iqk1yiw4	149	3	substrate	substrate	NN
cord-307860-iqk1yiw4	149	4	recognizes	recognize	VBZ
cord-307860-iqk1yiw4	149	5	the	the	DT
cord-307860-iqk1yiw4	149	6	Glu	Glu	NNP
cord-307860-iqk1yiw4	149	7	-	-	HYPH
cord-307860-iqk1yiw4	149	8	His	-PRON-	PRP$
cord-307860-iqk1yiw4	149	9	pair	pair	NN
cord-307860-iqk1yiw4	149	10	by	by	IN
cord-307860-iqk1yiw4	149	11	a	a	DT
cord-307860-iqk1yiw4	149	12	steric	steric	JJ
cord-307860-iqk1yiw4	149	13	effect	effect	NN
cord-307860-iqk1yiw4	149	14	.	.	.
cord-307860-iqk1yiw4	150	1	Three	three	CD
cord-307860-iqk1yiw4	150	2	more	more	JJR
cord-307860-iqk1yiw4	150	3	residues	residue	NNS
cord-307860-iqk1yiw4	150	4	have	have	VBP
cord-307860-iqk1yiw4	150	5	an	an	DT
cord-307860-iqk1yiw4	150	6	essential	essential	JJ
cord-307860-iqk1yiw4	150	7	role	role	NN
cord-307860-iqk1yiw4	150	8	in	in	IN
cord-307860-iqk1yiw4	150	9	the	the	DT
cord-307860-iqk1yiw4	150	10	glutamine	glutamine	NN
cord-307860-iqk1yiw4	150	11	substrate	substrate	NN
cord-307860-iqk1yiw4	150	12	interactions-	interactions-	XX
cord-307860-iqk1yiw4	151	1	the	the	DT
cord-307860-iqk1yiw4	151	2	His166	his166	CD
cord-307860-iqk1yiw4	151	3	and	and	CC
cord-307860-iqk1yiw4	151	4	the	the	DT
cord-307860-iqk1yiw4	151	5	nearby	nearby	JJ
cord-307860-iqk1yiw4	151	6	Tyr164	tyr164	NN
cord-307860-iqk1yiw4	151	7	and	and	CC
cord-307860-iqk1yiw4	151	8	Phe143	phe143	CD
cord-307860-iqk1yiw4	151	9	.	.	.
cord-307860-iqk1yiw4	152	1	The	the	DT
cord-307860-iqk1yiw4	152	2	tyrosine	tyrosine	NN
cord-307860-iqk1yiw4	152	3	residue	residue	NN
cord-307860-iqk1yiw4	152	4	forms	form	VBZ
cord-307860-iqk1yiw4	152	5	a	a	DT
cord-307860-iqk1yiw4	152	6	strong	strong	JJ
cord-307860-iqk1yiw4	152	7	hydrogen	hydrogen	NN
cord-307860-iqk1yiw4	152	8	bond	bond	NN
cord-307860-iqk1yiw4	152	9	with	with	IN
cord-307860-iqk1yiw4	152	10	His	-PRON-	PRP$
cord-307860-iqk1yiw4	152	11	and	and	CC
cord-307860-iqk1yiw4	152	12	the	the	DT
cord-307860-iqk1yiw4	152	13	phenylalanine	phenylalanine	NN
cord-307860-iqk1yiw4	152	14	residue	residue	NN
cord-307860-iqk1yiw4	152	15	employs	employ	VBZ
cord-307860-iqk1yiw4	152	16	a	a	DT
cord-307860-iqk1yiw4	152	17	steric	steric	JJ
cord-307860-iqk1yiw4	152	18	effect	effect	NN
cord-307860-iqk1yiw4	152	19	to	to	TO
cord-307860-iqk1yiw4	152	20	restrain	restrain	VB
cord-307860-iqk1yiw4	152	21	the	the	DT
cord-307860-iqk1yiw4	152	22	rotation	rotation	NN
cord-307860-iqk1yiw4	152	23	of	of	IN
cord-307860-iqk1yiw4	152	24	His	-PRON-	PRP$
cord-307860-iqk1yiw4	152	25	[	[	-LRB-
cord-307860-iqk1yiw4	152	26	67	67	CD
cord-307860-iqk1yiw4	152	27	]	]	-RRB-
cord-307860-iqk1yiw4	152	28	.	.	.
cord-307860-iqk1yiw4	153	1	The	the	DT
cord-307860-iqk1yiw4	153	2	multiple	multiple	JJ
cord-307860-iqk1yiw4	153	3	sequence	sequence	NN
cord-307860-iqk1yiw4	153	4	alignment	alignment	NN
cord-307860-iqk1yiw4	153	5	of	of	IN
cord-307860-iqk1yiw4	153	6	the	the	DT
cord-307860-iqk1yiw4	153	7	3CL	3cl	CD
cord-307860-iqk1yiw4	153	8	pro	pro	JJ
cord-307860-iqk1yiw4	153	9	sequences	sequence	NNS
cord-307860-iqk1yiw4	153	10	from	from	IN
cord-307860-iqk1yiw4	153	11	different	different	JJ
cord-307860-iqk1yiw4	153	12	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	153	13	allows	allow	VBZ
cord-307860-iqk1yiw4	153	14	an	an	DT
cord-307860-iqk1yiw4	153	15	overall	overall	JJ
cord-307860-iqk1yiw4	153	16	analysis	analysis	NN
cord-307860-iqk1yiw4	153	17	.	.	.
cord-307860-iqk1yiw4	154	1	Thus	thus	RB
cord-307860-iqk1yiw4	154	2	seven	seven	CD
cord-307860-iqk1yiw4	154	3	3CL	3cl	CD
cord-307860-iqk1yiw4	154	4	pro	pro	JJ
cord-307860-iqk1yiw4	154	5	from	from	IN
cord-307860-iqk1yiw4	154	6	the	the	DT
cord-307860-iqk1yiw4	154	7	following	follow	VBG
cord-307860-iqk1yiw4	154	8	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	154	9	were	be	VBD
cord-307860-iqk1yiw4	154	10	aligned	align	VBN
cord-307860-iqk1yiw4	154	11	using	use	VBG
cord-307860-iqk1yiw4	154	12	Clustal	Clustal	NNP
cord-307860-iqk1yiw4	154	13	Omega	Omega	NNP
cord-307860-iqk1yiw4	154	14	program	program	NN
cord-307860-iqk1yiw4	154	15	:	:	:
cord-307860-iqk1yiw4	155	1	feline	feline	JJ
cord-307860-iqk1yiw4	155	2	infectious	infectious	JJ
cord-307860-iqk1yiw4	155	3	peritonitis	peritonitis	NN
cord-307860-iqk1yiw4	155	4	virus	virus	NN
cord-307860-iqk1yiw4	155	5	FIPV	FIPV	NNP
cord-307860-iqk1yiw4	155	6	(	(	-LRB-
cord-307860-iqk1yiw4	155	7	PDB	PDB	NNP
cord-307860-iqk1yiw4	155	8	ID	ID	NNP
cord-307860-iqk1yiw4	155	9	5EU8	5eu8	CD
cord-307860-iqk1yiw4	155	10	)	)	-RRB-
cord-307860-iqk1yiw4	155	11	,	,	,
cord-307860-iqk1yiw4	155	12	porcine	porcine	JJ
cord-307860-iqk1yiw4	155	13	epidemic	epidemic	NN
cord-307860-iqk1yiw4	155	14	diarrhea	diarrhea	NN
cord-307860-iqk1yiw4	155	15	virus	virus	NN
cord-307860-iqk1yiw4	155	16	PEDV	PEDV	NNP
cord-307860-iqk1yiw4	155	17	(	(	-LRB-
cord-307860-iqk1yiw4	155	18	PDB	PDB	NNP
cord-307860-iqk1yiw4	155	19	ID	ID	NNP
cord-307860-iqk1yiw4	155	20	5GWZ	5GWZ	NNP
cord-307860-iqk1yiw4	155	21	)	)	-RRB-
cord-307860-iqk1yiw4	155	22	,	,	.
cord-307860-iqk1yiw4	156	1	human	human	JJ
cord-307860-iqk1yiw4	156	2	HCoV	HCoV	NNP
cord-307860-iqk1yiw4	156	3	-	-	HYPH
cord-307860-iqk1yiw4	156	4	NL63	nl63	NN
cord-307860-iqk1yiw4	157	1	(	(	-LRB-
cord-307860-iqk1yiw4	157	2	PDB	PDB	NNP
cord-307860-iqk1yiw4	157	3	ID	ID	NNP
cord-307860-iqk1yiw4	157	4	5GWY	5GWY	NNP
cord-307860-iqk1yiw4	157	5	)	)	-RRB-
cord-307860-iqk1yiw4	157	6	,	,	,
cord-307860-iqk1yiw4	157	7	SARS	SARS	NNP
cord-307860-iqk1yiw4	157	8	-	-	HYPH
cord-307860-iqk1yiw4	157	9	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	157	10	(	(	-LRB-
cord-307860-iqk1yiw4	157	11	PDB	PDB	NNP
cord-307860-iqk1yiw4	157	12	ID	ID	NNP
cord-307860-iqk1yiw4	157	13	6LU7	6lu7	CD
cord-307860-iqk1yiw4	157	14	)	)	-RRB-
cord-307860-iqk1yiw4	157	15	,	,	,
cord-307860-iqk1yiw4	157	16	SARS	SARS	NNP
cord-307860-iqk1yiw4	157	17	-	-	HYPH
cord-307860-iqk1yiw4	157	18	CoV	CoV	NNP
cord-307860-iqk1yiw4	157	19	(	(	-LRB-
cord-307860-iqk1yiw4	157	20	PDB	PDB	NNP
cord-307860-iqk1yiw4	157	21	ID	ID	NNP
cord-307860-iqk1yiw4	157	22	3IWM	3IWM	NNP
cord-307860-iqk1yiw4	157	23	)	)	-RRB-
cord-307860-iqk1yiw4	157	24	,	,	,
cord-307860-iqk1yiw4	157	25	human	human	JJ
cord-307860-iqk1yiw4	157	26	HCoV	HCoV	NNP
cord-307860-iqk1yiw4	157	27	-	-	HYPH
cord-307860-iqk1yiw4	157	28	HKU1	HKU1	NNP
cord-307860-iqk1yiw4	157	29	(	(	-LRB-
cord-307860-iqk1yiw4	157	30	PDB	PDB	NNP
cord-307860-iqk1yiw4	157	31	ID	ID	NNP
cord-307860-iqk1yiw4	157	32	3D23	3d23	CD
cord-307860-iqk1yiw4	157	33	)	)	-RRB-
cord-307860-iqk1yiw4	157	34	,	,	,
cord-307860-iqk1yiw4	157	35	MERS	MERS	NNP
cord-307860-iqk1yiw4	157	36	-	-	HYPH
cord-307860-iqk1yiw4	157	37	CoV	CoV	NNP
cord-307860-iqk1yiw4	157	38	(	(	-LRB-
cord-307860-iqk1yiw4	157	39	PDB	PDB	NNP
cord-307860-iqk1yiw4	157	40	ID	ID	NNP
cord-307860-iqk1yiw4	157	41	4RSP	4rsp	CD
cord-307860-iqk1yiw4	157	42	)	)	-RRB-
cord-307860-iqk1yiw4	157	43	,	,	,
cord-307860-iqk1yiw4	157	44	and	and	CC
cord-307860-iqk1yiw4	157	45	murine	murine	JJ
cord-307860-iqk1yiw4	157	46	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	157	47	(	(	-LRB-
cord-307860-iqk1yiw4	157	48	strain	strain	NN
cord-307860-iqk1yiw4	157	49	A59	A59	NNP
cord-307860-iqk1yiw4	157	50	)	)	-RRB-
cord-307860-iqk1yiw4	158	1	MHV	MHV	NNP
cord-307860-iqk1yiw4	158	2	-	-	HYPH
cord-307860-iqk1yiw4	158	3	A59	A59	NNP
cord-307860-iqk1yiw4	159	1	(	(	-LRB-
cord-307860-iqk1yiw4	159	2	PDB	PDB	NNP
cord-307860-iqk1yiw4	159	3	ID	ID	NNP
cord-307860-iqk1yiw4	159	4	6JIJ	6jij	CD
cord-307860-iqk1yiw4	159	5	)	)	-RRB-
cord-307860-iqk1yiw4	159	6	.	.	.
cord-307860-iqk1yiw4	160	1	The	the	DT
cord-307860-iqk1yiw4	160	2	residues	residue	NNS
cord-307860-iqk1yiw4	160	3	essential	essential	JJ
cord-307860-iqk1yiw4	160	4	for	for	IN
cord-307860-iqk1yiw4	160	5	catalysis	catalysis	NN
cord-307860-iqk1yiw4	160	6	-	-	:
cord-307860-iqk1yiw4	160	7	the	the	DT
cord-307860-iqk1yiw4	160	8	Cys145-His41	Cys145-His41	NNP
cord-307860-iqk1yiw4	160	9	dyad	dyad	NN
cord-307860-iqk1yiw4	160	10	and	and	CC
cord-307860-iqk1yiw4	160	11	the	the	DT
cord-307860-iqk1yiw4	160	12	GSCGS	GSCGS	NNP
cord-307860-iqk1yiw4	160	13	motif	motif	NN
cord-307860-iqk1yiw4	160	14	highly	highly	RB
cord-307860-iqk1yiw4	160	15	conserved	conserve	VBN
cord-307860-iqk1yiw4	160	16	in	in	IN
cord-307860-iqk1yiw4	160	17	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	160	18	-	-	,
cord-307860-iqk1yiw4	160	19	are	be	VBP
cord-307860-iqk1yiw4	160	20	shown	show	VBN
cord-307860-iqk1yiw4	160	21	in	in	IN
cord-307860-iqk1yiw4	160	22	Fig	Fig	NNP
cord-307860-iqk1yiw4	160	23	.	.	.
cord-307860-iqk1yiw4	161	1	2	2	LS
cord-307860-iqk1yiw4	161	2	.	.	.
cord-307860-iqk1yiw4	162	1	The	the	DT
cord-307860-iqk1yiw4	162	2	phylogenetic	phylogenetic	JJ
cord-307860-iqk1yiw4	162	3	tree	tree	NN
cord-307860-iqk1yiw4	162	4	(	(	-LRB-
cord-307860-iqk1yiw4	162	5	cladogram	cladogram	NN
cord-307860-iqk1yiw4	162	6	)	)	-RRB-
cord-307860-iqk1yiw4	162	7	of	of	IN
cord-307860-iqk1yiw4	162	8	the	the	DT
cord-307860-iqk1yiw4	162	9	3CL	3cl	CD
cord-307860-iqk1yiw4	162	10	pro	pro	NN
cord-307860-iqk1yiw4	162	11	from	from	IN
cord-307860-iqk1yiw4	162	12	different	different	JJ
cord-307860-iqk1yiw4	162	13	CoVs	covs	NN
cord-307860-iqk1yiw4	162	14	sequences	sequence	NNS
cord-307860-iqk1yiw4	162	15	analyzed	analyze	VBD
cord-307860-iqk1yiw4	162	16	confirms	confirm	VBZ
cord-307860-iqk1yiw4	162	17	that	that	IN
cord-307860-iqk1yiw4	162	18	SARS	SARS	NNP
cord-307860-iqk1yiw4	162	19	-	-	HYPH
cord-307860-iqk1yiw4	162	20	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	162	21	is	be	VBZ
cord-307860-iqk1yiw4	162	22	closer	close	JJR
cord-307860-iqk1yiw4	162	23	to	to	IN
cord-307860-iqk1yiw4	162	24	the	the	DT
cord-307860-iqk1yiw4	162	25	SARS	SARS	NNP
cord-307860-iqk1yiw4	162	26	-	-	HYPH
cord-307860-iqk1yiw4	162	27	CoV	CoV	NNP
cord-307860-iqk1yiw4	162	28	(	(	-LRB-
cord-307860-iqk1yiw4	162	29	Fig	Fig	NNP
cord-307860-iqk1yiw4	162	30	.	.	.
cord-307860-iqk1yiw4	162	31	3	3	CD
cord-307860-iqk1yiw4	162	32	)	)	-RRB-
cord-307860-iqk1yiw4	162	33	.	.	.
cord-307860-iqk1yiw4	163	1	The	the	DT
cord-307860-iqk1yiw4	163	2	multiple	multiple	JJ
cord-307860-iqk1yiw4	163	3	sequence	sequence	NN
cord-307860-iqk1yiw4	163	4	alignment	alignment	NN
cord-307860-iqk1yiw4	163	5	of	of	IN
cord-307860-iqk1yiw4	163	6	3CL	3CL	NNP
cord-307860-iqk1yiw4	163	7	pro	pro	NN
cord-307860-iqk1yiw4	163	8	of	of	IN
cord-307860-iqk1yiw4	163	9	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	163	10	of	of	IN
cord-307860-iqk1yiw4	163	11	different	different	JJ
cord-307860-iqk1yiw4	163	12	origin	origin	NN
cord-307860-iqk1yiw4	163	13	(	(	-LRB-
cord-307860-iqk1yiw4	163	14	using	use	VBG
cord-307860-iqk1yiw4	163	15	the	the	DT
cord-307860-iqk1yiw4	163	16	Clustal	Clustal	NNP
cord-307860-iqk1yiw4	163	17	Omega	Omega	NNP
cord-307860-iqk1yiw4	163	18	program	program	NN
cord-307860-iqk1yiw4	163	19	)	)	-RRB-
cord-307860-iqk1yiw4	163	20	.	.	.
cord-307860-iqk1yiw4	164	1	The	the	DT
cord-307860-iqk1yiw4	164	2	Cys145	cys145	NN
cord-307860-iqk1yiw4	164	3	of	of	IN
cord-307860-iqk1yiw4	164	4	SARS	SARS	NNP
cord-307860-iqk1yiw4	164	5	-	-	HYPH
cord-307860-iqk1yiw4	164	6	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	164	7	3CL	3cl	CD
cord-307860-iqk1yiw4	164	8	pro	pro	JJ
cord-307860-iqk1yiw4	164	9	that	that	WDT
cord-307860-iqk1yiw4	164	10	interact	interact	VBP
cord-307860-iqk1yiw4	164	11	with	with	IN
cord-307860-iqk1yiw4	164	12	the	the	DT
cord-307860-iqk1yiw4	164	13	compounds	compound	NNS
cord-307860-iqk1yiw4	164	14	11a	11a	NNS
cord-307860-iqk1yiw4	164	15	and	and	CC
cord-307860-iqk1yiw4	164	16	11b	11b	NNS
cord-307860-iqk1yiw4	164	17	is	be	VBZ
cord-307860-iqk1yiw4	164	18	shown	show	VBN
cord-307860-iqk1yiw4	164	19	in	in	IN
cord-307860-iqk1yiw4	164	20	black	black	JJ
cord-307860-iqk1yiw4	164	21	background	background	NN
cord-307860-iqk1yiw4	164	22	along	along	IN
cord-307860-iqk1yiw4	164	23	with	with	IN
cord-307860-iqk1yiw4	164	24	the	the	DT
cord-307860-iqk1yiw4	164	25	Cys145-His41	cys145-his41	NN
cord-307860-iqk1yiw4	164	26	catalytic	catalytic	JJ
cord-307860-iqk1yiw4	164	27	dyad	dyad	NN
cord-307860-iqk1yiw4	164	28	highly	highly	RB
cord-307860-iqk1yiw4	164	29	conserved	conserve	VBN
cord-307860-iqk1yiw4	164	30	in	in	IN
cord-307860-iqk1yiw4	164	31	3CL	3cl	CD
cord-307860-iqk1yiw4	164	32	pro	pro	NN
cord-307860-iqk1yiw4	164	33	from	from	IN
cord-307860-iqk1yiw4	164	34	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	164	35	[	[	-LRB-
cord-307860-iqk1yiw4	164	36	42	42	CD
cord-307860-iqk1yiw4	164	37	,	,	,
cord-307860-iqk1yiw4	164	38	44	44	CD
cord-307860-iqk1yiw4	164	39	,	,	,
cord-307860-iqk1yiw4	164	40	59	59	CD
cord-307860-iqk1yiw4	164	41	,	,	,
cord-307860-iqk1yiw4	164	42	65	65	CD
cord-307860-iqk1yiw4	164	43	,	,	,
cord-307860-iqk1yiw4	164	44	66	66	CD
cord-307860-iqk1yiw4	164	45	]	]	-RRB-
cord-307860-iqk1yiw4	164	46	;	;	:
cord-307860-iqk1yiw4	164	47	in	in	IN
cord-307860-iqk1yiw4	164	48	green	green	JJ
cord-307860-iqk1yiw4	164	49	are	be	VBP
cord-307860-iqk1yiw4	164	50	marked	mark	VBN
cord-307860-iqk1yiw4	164	51	the	the	DT
cord-307860-iqk1yiw4	164	52	cluster	cluster	NN
cord-307860-iqk1yiw4	164	53	of	of	IN
cord-307860-iqk1yiw4	164	54	Ser	Ser	NNP
cord-307860-iqk1yiw4	164	55	with	with	IN
cord-307860-iqk1yiw4	164	56	high	high	JJ
cord-307860-iqk1yiw4	164	57	affinity	affinity	NN
cord-307860-iqk1yiw4	164	58	for	for	IN
cord-307860-iqk1yiw4	164	59	small	small	JJ
cord-307860-iqk1yiw4	164	60	molecule	molecule	NN
cord-307860-iqk1yiw4	164	61	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	164	62	[	[	-LRB-
cord-307860-iqk1yiw4	164	63	44	44	CD
cord-307860-iqk1yiw4	164	64	,	,	,
cord-307860-iqk1yiw4	164	65	55	55	CD
cord-307860-iqk1yiw4	164	66	]	]	-RRB-
cord-307860-iqk1yiw4	164	67	;	;	:
cord-307860-iqk1yiw4	164	68	in	in	IN
cord-307860-iqk1yiw4	164	69	green	green	NN
cord-307860-iqk1yiw4	164	70	it	-PRON-	PRP
cord-307860-iqk1yiw4	164	71	is	be	VBZ
cord-307860-iqk1yiw4	164	72	shown	show	VBN
cord-307860-iqk1yiw4	164	73	the	the	DT
cord-307860-iqk1yiw4	164	74	GSCGS	GSCGS	NNP
cord-307860-iqk1yiw4	164	75	motif	motif	NN
cord-307860-iqk1yiw4	164	76	essential	essential	JJ
cord-307860-iqk1yiw4	164	77	for	for	IN
cord-307860-iqk1yiw4	164	78	starting	start	VBG
cord-307860-iqk1yiw4	164	79	the	the	DT
cord-307860-iqk1yiw4	164	80	catalysis	catalysis	NN
cord-307860-iqk1yiw4	164	81	;	;	:
cord-307860-iqk1yiw4	164	82	in	in	IN
cord-307860-iqk1yiw4	164	83	light	light	JJ
cord-307860-iqk1yiw4	164	84	blue	blue	NN
cord-307860-iqk1yiw4	164	85	are	be	VBP
cord-307860-iqk1yiw4	164	86	marked	mark	VBN
cord-307860-iqk1yiw4	164	87	the	the	DT
cord-307860-iqk1yiw4	164	88	Glu	Glu	NNP
cord-307860-iqk1yiw4	164	89	-	-	HYPH
cord-307860-iqk1yiw4	164	90	His	-PRON-	PRP$
cord-307860-iqk1yiw4	164	91	residues	residue	NNS
cord-307860-iqk1yiw4	164	92	critical	critical	JJ
cord-307860-iqk1yiw4	164	93	for	for	IN
cord-307860-iqk1yiw4	164	94	substrate	substrate	NN
cord-307860-iqk1yiw4	164	95	binding	bind	VBG
cord-307860-iqk1yiw4	164	96	by	by	IN
cord-307860-iqk1yiw4	164	97	means	mean	NNS
cord-307860-iqk1yiw4	164	98	of	of	IN
cord-307860-iqk1yiw4	164	99	steric	steric	JJ
cord-307860-iqk1yiw4	164	100	effect	effect	NN
cord-307860-iqk1yiw4	164	101	;	;	:
cord-307860-iqk1yiw4	164	102	in	in	IN
cord-307860-iqk1yiw4	164	103	yellow	yellow	JJ
cord-307860-iqk1yiw4	164	104	background	background	NN
cord-307860-iqk1yiw4	164	105	is	be	VBZ
cord-307860-iqk1yiw4	164	106	marked	mark	VBN
cord-307860-iqk1yiw4	164	107	the	the	DT
cord-307860-iqk1yiw4	164	108	triad	triad	NN
cord-307860-iqk1yiw4	164	109	Arg	Arg	NNP
cord-307860-iqk1yiw4	164	110	-	-	HYPH
cord-307860-iqk1yiw4	164	111	Tyr	Tyr	NNP
cord-307860-iqk1yiw4	164	112	-	-	HYPH
cord-307860-iqk1yiw4	164	113	Asp	Asp	NNP
cord-307860-iqk1yiw4	164	114	that	that	WDT
cord-307860-iqk1yiw4	164	115	forms	form	VBZ
cord-307860-iqk1yiw4	164	116	a	a	DT
cord-307860-iqk1yiw4	164	117	partial	partial	JJ
cord-307860-iqk1yiw4	164	118	neg	neg	JJ
cord-307860-iqk1yiw4	164	119	-	-	JJ
cord-307860-iqk1yiw4	164	120	ative	ative	JJ
cord-307860-iqk1yiw4	164	121	charge	charge	NN
cord-307860-iqk1yiw4	164	122	cluster	cluster	NN
cord-307860-iqk1yiw4	164	123	that	that	IN
cord-307860-iqk1yiw4	164	124	,	,	,
cord-307860-iqk1yiw4	164	125	by	by	IN
cord-307860-iqk1yiw4	164	126	a	a	DT
cord-307860-iqk1yiw4	164	127	conserved	conserved	JJ
cord-307860-iqk1yiw4	164	128	water	water	NN
cord-307860-iqk1yiw4	164	129	molecule	molecule	NN
cord-307860-iqk1yiw4	164	130	,	,	,
cord-307860-iqk1yiw4	164	131	mediates	mediate	VBZ
cord-307860-iqk1yiw4	164	132	the	the	DT
cord-307860-iqk1yiw4	164	133	interaction	interaction	NN
cord-307860-iqk1yiw4	164	134	with	with	IN
cord-307860-iqk1yiw4	164	135	Cys	Cys	NNP
cord-307860-iqk1yiw4	164	136	-	-	HYPH
cord-307860-iqk1yiw4	164	137	His	-PRON-	PRP$
cord-307860-iqk1yiw4	164	138	catalytic	catalytic	JJ
cord-307860-iqk1yiw4	164	139	dyad	dyad	NN
cord-307860-iqk1yiw4	164	140	;	;	:
cord-307860-iqk1yiw4	164	141	in	in	IN
cord-307860-iqk1yiw4	164	142	brown	brown	NNP
cord-307860-iqk1yiw4	164	143	are	be	VBP
cord-307860-iqk1yiw4	164	144	shown	show	VBN
cord-307860-iqk1yiw4	164	145	the	the	DT
cord-307860-iqk1yiw4	164	146	residues	residue	NNS
cord-307860-iqk1yiw4	164	147	involved	involve	VBN
cord-307860-iqk1yiw4	164	148	in	in	IN
cord-307860-iqk1yiw4	164	149	the	the	DT
cord-307860-iqk1yiw4	164	150	glutamine	glutamine	NN
cord-307860-iqk1yiw4	164	151	substrate	substrate	NN
cord-307860-iqk1yiw4	164	152	recognition-	recognition-	NN
cord-307860-iqk1yiw4	165	1	the	the	DT
cord-307860-iqk1yiw4	165	2	conserved	conserve	VBN
cord-307860-iqk1yiw4	165	3	His	-PRON-	PRP$
cord-307860-iqk1yiw4	165	4	and	and	CC
cord-307860-iqk1yiw4	165	5	the	the	DT
cord-307860-iqk1yiw4	165	6	conserved	conserve	VBN
cord-307860-iqk1yiw4	165	7	Tyr	Tyr	NNP
cord-307860-iqk1yiw4	165	8	and	and	CC
cord-307860-iqk1yiw4	165	9	Phe	Phe	NNP
cord-307860-iqk1yiw4	165	10	that	that	WDT
cord-307860-iqk1yiw4	165	11	interacts	interact	VBZ
cord-307860-iqk1yiw4	165	12	with	with	IN
cord-307860-iqk1yiw4	165	13	by	by	IN
cord-307860-iqk1yiw4	165	14	the	the	DT
cord-307860-iqk1yiw4	165	15	phenolic	phenolic	JJ
cord-307860-iqk1yiw4	165	16	hydroxyl	hydroxyl	NN
cord-307860-iqk1yiw4	165	17	group	group	NN
cord-307860-iqk1yiw4	165	18	with	with	IN
cord-307860-iqk1yiw4	165	19	His	-PRON-	PRP
cord-307860-iqk1yiw4	165	20	and	and	CC
cord-307860-iqk1yiw4	165	21	employs	employ	VBZ
cord-307860-iqk1yiw4	165	22	a	a	DT
cord-307860-iqk1yiw4	165	23	steric	steric	JJ
cord-307860-iqk1yiw4	165	24	effect	effect	NN
cord-307860-iqk1yiw4	165	25	to	to	TO
cord-307860-iqk1yiw4	165	26	restrain	restrain	VB
cord-307860-iqk1yiw4	165	27	the	the	DT
cord-307860-iqk1yiw4	165	28	rotation	rotation	NN
cord-307860-iqk1yiw4	165	29	of	of	IN
cord-307860-iqk1yiw4	165	30	His	-PRON-	PRP$
cord-307860-iqk1yiw4	165	31	,	,	,
cord-307860-iqk1yiw4	165	32	respectively	respectively	RB
cord-307860-iqk1yiw4	165	33	;	;	:
cord-307860-iqk1yiw4	165	34	in	in	IN
cord-307860-iqk1yiw4	165	35	bold	bold	JJ
cord-307860-iqk1yiw4	165	36	-	-	HYPH
cord-307860-iqk1yiw4	165	37	underline	underline	NN
cord-307860-iqk1yiw4	165	38	are	be	VBP
cord-307860-iqk1yiw4	165	39	marked	mark	VBN
cord-307860-iqk1yiw4	165	40	the	the	DT
cord-307860-iqk1yiw4	165	41	Glu	Glu	NNP
cord-307860-iqk1yiw4	165	42	and	and	CC
cord-307860-iqk1yiw4	165	43	Ser	Ser	NNP
cord-307860-iqk1yiw4	165	44	residues	residue	NNS
cord-307860-iqk1yiw4	165	45	that	that	WDT
cord-307860-iqk1yiw4	165	46	are	be	VBP
cord-307860-iqk1yiw4	165	47	demonstrated	demonstrate	VBN
cord-307860-iqk1yiw4	165	48	to	to	TO
cord-307860-iqk1yiw4	165	49	be	be	VB
cord-307860-iqk1yiw4	165	50	essential	essential	JJ
cord-307860-iqk1yiw4	165	51	in	in	IN
cord-307860-iqk1yiw4	165	52	the	the	DT
cord-307860-iqk1yiw4	165	53	dimer	dimer	NN
cord-307860-iqk1yiw4	165	54	interactions	interaction	NNS
cord-307860-iqk1yiw4	165	55	in	in	IN
cord-307860-iqk1yiw4	165	56	SARS	SARS	NNP
cord-307860-iqk1yiw4	165	57	-	-	HYPH
cord-307860-iqk1yiw4	165	58	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	165	59	[	[	-LRB-
cord-307860-iqk1yiw4	165	60	60	60	CD
cord-307860-iqk1yiw4	165	61	]	]	-RRB-
cord-307860-iqk1yiw4	165	62	;	;	:
cord-307860-iqk1yiw4	165	63	with	with	IN
cord-307860-iqk1yiw4	165	64	dot	dot	NN
cord-307860-iqk1yiw4	165	65	"	"	''
cord-307860-iqk1yiw4	165	66	.	.	.
cord-307860-iqk1yiw4	166	1	"	"	``
cord-307860-iqk1yiw4	166	2	are	be	VBP
cord-307860-iqk1yiw4	166	3	marked	mark	VBN
cord-307860-iqk1yiw4	166	4	the	the	DT
cord-307860-iqk1yiw4	166	5	semiconservative	semiconservative	JJ
cord-307860-iqk1yiw4	166	6	replacements	replacement	NNS
cord-307860-iqk1yiw4	166	7	;	;	:
cord-307860-iqk1yiw4	166	8	with	with	IN
cord-307860-iqk1yiw4	166	9	colon	colon	NN
cord-307860-iqk1yiw4	166	10	"	"	''
cord-307860-iqk1yiw4	166	11	:	:	:
cord-307860-iqk1yiw4	166	12	"	"	``
cord-307860-iqk1yiw4	166	13	are	be	VBP
cord-307860-iqk1yiw4	166	14	marked	mark	VBN
cord-307860-iqk1yiw4	166	15	the	the	DT
cord-307860-iqk1yiw4	166	16	conservative	conservative	JJ
cord-307860-iqk1yiw4	166	17	replacements	replacement	NNS
cord-307860-iqk1yiw4	166	18	;	;	:
cord-307860-iqk1yiw4	166	19	with	with	IN
cord-307860-iqk1yiw4	166	20	"	"	``
cord-307860-iqk1yiw4	166	21	*	*	NFP
cord-307860-iqk1yiw4	166	22	"	"	''
cord-307860-iqk1yiw4	166	23	are	be	VBP
cord-307860-iqk1yiw4	166	24	marked	mark	VBN
cord-307860-iqk1yiw4	166	25	the	the	DT
cord-307860-iqk1yiw4	166	26	identities	identity	NNS
cord-307860-iqk1yiw4	166	27	of	of	IN
cord-307860-iqk1yiw4	166	28	the	the	DT
cord-307860-iqk1yiw4	166	29	residues	residue	NNS
cord-307860-iqk1yiw4	166	30	The	the	DT
cord-307860-iqk1yiw4	166	31	RNA	RNA	NNP
cord-307860-iqk1yiw4	166	32	-	-	HYPH
cord-307860-iqk1yiw4	166	33	dependent	dependent	JJ
cord-307860-iqk1yiw4	166	34	RNA	RNA	NNP
cord-307860-iqk1yiw4	166	35	polymerase	polymerase	NN
cord-307860-iqk1yiw4	166	36	(	(	-LRB-
cord-307860-iqk1yiw4	166	37	RdRp	RdRp	NNP
cord-307860-iqk1yiw4	166	38	)	)	-RRB-
cord-307860-iqk1yiw4	166	39	(	(	-LRB-
cord-307860-iqk1yiw4	166	40	UniProtKB	uniprotkb	CD
cord-307860-iqk1yiw4	166	41	P0DTD1	P0DTD1	NNS
cord-307860-iqk1yiw4	166	42	)	)	-RRB-
cord-307860-iqk1yiw4	166	43	,	,	,
cord-307860-iqk1yiw4	166	44	also	also	RB
cord-307860-iqk1yiw4	166	45	known	know	VBN
cord-307860-iqk1yiw4	166	46	as	as	IN
cord-307860-iqk1yiw4	166	47	nsp12	nsp12	CD
cord-307860-iqk1yiw4	166	48	,	,	,
cord-307860-iqk1yiw4	166	49	is	be	VBZ
cord-307860-iqk1yiw4	166	50	responsible	responsible	JJ
cord-307860-iqk1yiw4	166	51	for	for	IN
cord-307860-iqk1yiw4	166	52	the	the	DT
cord-307860-iqk1yiw4	166	53	replication	replication	NN
cord-307860-iqk1yiw4	166	54	and	and	CC
cord-307860-iqk1yiw4	166	55	transcription	transcription	NN
cord-307860-iqk1yiw4	166	56	of	of	IN
cord-307860-iqk1yiw4	166	57	the	the	DT
cord-307860-iqk1yiw4	166	58	viral	viral	JJ
cord-307860-iqk1yiw4	166	59	genome	genome	NN
cord-307860-iqk1yiw4	166	60	.	.	.
cord-307860-iqk1yiw4	167	1	The	the	DT
cord-307860-iqk1yiw4	167	2	RdRp	RdRp	NNP
cord-307860-iqk1yiw4	167	3	complex	complex	NN
cord-307860-iqk1yiw4	167	4	is	be	VBZ
cord-307860-iqk1yiw4	167	5	composed	compose	VBN
cord-307860-iqk1yiw4	167	6	of	of	IN
cord-307860-iqk1yiw4	167	7	the	the	DT
cord-307860-iqk1yiw4	167	8	nsp12	nsp12	NNS
cord-307860-iqk1yiw4	167	9	,	,	,
cord-307860-iqk1yiw4	167	10	nsp7	nsp7	UH
cord-307860-iqk1yiw4	167	11	,	,	,
cord-307860-iqk1yiw4	167	12	and	and	CC
cord-307860-iqk1yiw4	167	13	nsp8	nsp8	NN
cord-307860-iqk1yiw4	167	14	.	.	.
cord-307860-iqk1yiw4	168	1	The	the	DT
cord-307860-iqk1yiw4	168	2	nsp12	nsp12	NNS
cord-307860-iqk1yiw4	168	3	is	be	VBZ
cord-307860-iqk1yiw4	168	4	the	the	DT
cord-307860-iqk1yiw4	168	5	catalytic	catalytic	JJ
cord-307860-iqk1yiw4	168	6	subunit	subunit	NN
cord-307860-iqk1yiw4	168	7	and	and	CC
cord-307860-iqk1yiw4	168	8	needs	need	VBZ
cord-307860-iqk1yiw4	168	9	the	the	DT
cord-307860-iqk1yiw4	168	10	nsp7	nsp7	NN
cord-307860-iqk1yiw4	168	11	and	and	CC
cord-307860-iqk1yiw4	168	12	nsp8	nsp8	NN
cord-307860-iqk1yiw4	168	13	(	(	-LRB-
cord-307860-iqk1yiw4	168	14	eight	eight	CD
cord-307860-iqk1yiw4	168	15	subunits	subunit	NNS
cord-307860-iqk1yiw4	168	16	of	of	IN
cord-307860-iqk1yiw4	168	17	each	each	DT
cord-307860-iqk1yiw4	168	18	)	)	-RRB-
cord-307860-iqk1yiw4	168	19	to	to	TO
cord-307860-iqk1yiw4	168	20	fulfill	fulfill	VB
cord-307860-iqk1yiw4	168	21	the	the	DT
cord-307860-iqk1yiw4	168	22	replication	replication	NN
cord-307860-iqk1yiw4	168	23	process	process	NN
cord-307860-iqk1yiw4	168	24	.	.	.
cord-307860-iqk1yiw4	169	1	The	the	DT
cord-307860-iqk1yiw4	169	2	RdRp	RdRp	NNP
cord-307860-iqk1yiw4	169	3	is	be	VBZ
cord-307860-iqk1yiw4	169	4	considered	consider	VBN
cord-307860-iqk1yiw4	169	5	an	an	DT
cord-307860-iqk1yiw4	169	6	important	important	JJ
cord-307860-iqk1yiw4	169	7	target	target	NN
cord-307860-iqk1yiw4	169	8	for	for	IN
cord-307860-iqk1yiw4	169	9	new	new	JJ
cord-307860-iqk1yiw4	169	10	/	/	SYM
cord-307860-iqk1yiw4	169	11	already	already	RB
cord-307860-iqk1yiw4	169	12	known	know	VBN
cord-307860-iqk1yiw4	169	13	drugs	drug	NNS
cord-307860-iqk1yiw4	169	14	because	because	IN
cord-307860-iqk1yiw4	169	15	of	of	IN
cord-307860-iqk1yiw4	169	16	its	-PRON-	PRP$
cord-307860-iqk1yiw4	169	17	evolutionary	evolutionary	JJ
cord-307860-iqk1yiw4	169	18	stability	stability	NN
cord-307860-iqk1yiw4	169	19	compared	compare	VBN
cord-307860-iqk1yiw4	169	20	with	with	IN
cord-307860-iqk1yiw4	169	21	the	the	DT
cord-307860-iqk1yiw4	169	22	S	s	NN
cord-307860-iqk1yiw4	169	23	glycoproteins	glycoprotein	NNS
cord-307860-iqk1yiw4	169	24	that	that	WDT
cord-307860-iqk1yiw4	169	25	are	be	VBP
cord-307860-iqk1yiw4	169	26	more	more	RBR
cord-307860-iqk1yiw4	169	27	prone	prone	JJ
cord-307860-iqk1yiw4	169	28	to	to	IN
cord-307860-iqk1yiw4	169	29	mutations	mutation	NNS
cord-307860-iqk1yiw4	169	30	under	under	IN
cord-307860-iqk1yiw4	169	31	selections	selection	NNS
cord-307860-iqk1yiw4	169	32	of	of	IN
cord-307860-iqk1yiw4	169	33	host	host	NN
cord-307860-iqk1yiw4	169	34	immunity	immunity	NN
cord-307860-iqk1yiw4	169	35	[	[	-LRB-
cord-307860-iqk1yiw4	169	36	48	48	CD
cord-307860-iqk1yiw4	169	37	,	,	,
cord-307860-iqk1yiw4	169	38	68	68	CD
cord-307860-iqk1yiw4	169	39	]	]	-RRB-
cord-307860-iqk1yiw4	169	40	.	.	.
cord-307860-iqk1yiw4	170	1	A	a	DT
cord-307860-iqk1yiw4	170	2	recent	recent	JJ
cord-307860-iqk1yiw4	170	3	study	study	NN
cord-307860-iqk1yiw4	170	4	investigated	investigate	VBD
cord-307860-iqk1yiw4	170	5	the	the	DT
cord-307860-iqk1yiw4	170	6	feasibility	feasibility	NN
cord-307860-iqk1yiw4	170	7	of	of	IN
cord-307860-iqk1yiw4	170	8	the	the	DT
cord-307860-iqk1yiw4	170	9	RdRp	RdRp	NNP
cord-307860-iqk1yiw4	170	10	to	to	TO
cord-307860-iqk1yiw4	170	11	be	be	VB
cord-307860-iqk1yiw4	170	12	targeted	target	VBN
cord-307860-iqk1yiw4	170	13	by	by	IN
cord-307860-iqk1yiw4	170	14	novel	novel	JJ
cord-307860-iqk1yiw4	170	15	nucleoside	nucleoside	NN
cord-307860-iqk1yiw4	170	16	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	170	17	or	or	CC
cord-307860-iqk1yiw4	170	18	small	small	JJ
cord-307860-iqk1yiw4	170	19	molecules	molecule	NNS
cord-307860-iqk1yiw4	170	20	[	[	-LRB-
cord-307860-iqk1yiw4	170	21	69	69	CD
cord-307860-iqk1yiw4	170	22	]	]	-RRB-
cord-307860-iqk1yiw4	170	23	.	.	.
cord-307860-iqk1yiw4	171	1	One	one	CD
cord-307860-iqk1yiw4	171	2	previous	previous	JJ
cord-307860-iqk1yiw4	171	3	work	work	NN
cord-307860-iqk1yiw4	171	4	has	have	VBZ
cord-307860-iqk1yiw4	171	5	shown	show	VBN
cord-307860-iqk1yiw4	171	6	that	that	IN
cord-307860-iqk1yiw4	171	7	nsp7	nsp7	NN
cord-307860-iqk1yiw4	171	8	and	and	CC
cord-307860-iqk1yiw4	171	9	nsp8	nsp8	NN
cord-307860-iqk1yiw4	171	10	of	of	IN
cord-307860-iqk1yiw4	171	11	feline	feline	JJ
cord-307860-iqk1yiw4	171	12	CoV	cov	NN
cord-307860-iqk1yiw4	171	13	form	form	NN
cord-307860-iqk1yiw4	171	14	a	a	DT
cord-307860-iqk1yiw4	171	15	2:1	2:1	CD
cord-307860-iqk1yiw4	171	16	heterodimer	heterodimer	NN
cord-307860-iqk1yiw4	171	17	(	(	-LRB-
cord-307860-iqk1yiw4	171	18	PDB	PDB	NNP
cord-307860-iqk1yiw4	171	19	ID	ID	NNP
cord-307860-iqk1yiw4	171	20	3UB0	3ub0	CD
cord-307860-iqk1yiw4	171	21	)	)	-RRB-
cord-307860-iqk1yiw4	171	22	.	.	.
cord-307860-iqk1yiw4	172	1	The	the	DT
cord-307860-iqk1yiw4	172	2	nsp7	nsp7	NN
cord-307860-iqk1yiw4	172	3	and	and	CC
cord-307860-iqk1yiw4	172	4	nsp8	nsp8	NN
cord-307860-iqk1yiw4	172	5	from	from	IN
cord-307860-iqk1yiw4	172	6	the	the	DT
cord-307860-iqk1yiw4	172	7	SARS	SARS	NNP
cord-307860-iqk1yiw4	172	8	-	-	HYPH
cord-307860-iqk1yiw4	172	9	CoV	CoV	NNP
cord-307860-iqk1yiw4	172	10	form	form	NN
cord-307860-iqk1yiw4	172	11	an	an	DT
cord-307860-iqk1yiw4	172	12	8:8	8:8	CD
cord-307860-iqk1yiw4	172	13	hexadecamer	hexadecamer	NN
cord-307860-iqk1yiw4	172	14	(	(	-LRB-
cord-307860-iqk1yiw4	172	15	PDB	PDB	NNP
cord-307860-iqk1yiw4	172	16	ID	ID	NNP
cord-307860-iqk1yiw4	172	17	6NUR	6NUR	NNP
cord-307860-iqk1yiw4	172	18	)	)	-RRB-
cord-307860-iqk1yiw4	172	19	and	and	CC
cord-307860-iqk1yiw4	172	20	act	act	VB
cord-307860-iqk1yiw4	172	21	as	as	IN
cord-307860-iqk1yiw4	172	22	primase	primase	NN
cord-307860-iqk1yiw4	172	23	during	during	IN
cord-307860-iqk1yiw4	172	24	viral	viral	JJ
cord-307860-iqk1yiw4	172	25	replication	replication	NN
cord-307860-iqk1yiw4	172	26	[	[	-LRB-
cord-307860-iqk1yiw4	172	27	70	70	CD
cord-307860-iqk1yiw4	172	28	]	]	-RRB-
cord-307860-iqk1yiw4	172	29	[	[	-LRB-
cord-307860-iqk1yiw4	172	30	71	71	CD
cord-307860-iqk1yiw4	172	31	]	]	-RRB-
cord-307860-iqk1yiw4	172	32	[	[	-LRB-
cord-307860-iqk1yiw4	172	33	72	72	CD
cord-307860-iqk1yiw4	172	34	]	]	-RRB-
cord-307860-iqk1yiw4	172	35	.	.	.
cord-307860-iqk1yiw4	173	1	Remdesivir	Remdesivir	NNP
cord-307860-iqk1yiw4	173	2	(	(	-LRB-
cord-307860-iqk1yiw4	173	3	GS-5734	GS-5734	NNP
cord-307860-iqk1yiw4	173	4	)	)	-RRB-
cord-307860-iqk1yiw4	174	1	(	(	-LRB-
cord-307860-iqk1yiw4	174	2	PubChem	PubChem	NNP
cord-307860-iqk1yiw4	174	3	CID	CID	NNP
cord-307860-iqk1yiw4	174	4	121304016	121304016	CD
cord-307860-iqk1yiw4	174	5	)	)	-RRB-
cord-307860-iqk1yiw4	175	1	(	(	-LRB-
cord-307860-iqk1yiw4	175	2	DrugBank	DrugBank	NNP
cord-307860-iqk1yiw4	175	3	DB14761	DB14761	NNP
cord-307860-iqk1yiw4	175	4	)	)	-RRB-
cord-307860-iqk1yiw4	175	5	is	be	VBZ
cord-307860-iqk1yiw4	175	6	a	a	DT
cord-307860-iqk1yiw4	175	7	prodrug	prodrug	NN
cord-307860-iqk1yiw4	175	8	of	of	IN
cord-307860-iqk1yiw4	175	9	adenosine	adenosine	NN
cord-307860-iqk1yiw4	175	10	triphosphate	triphosphate	NN
cord-307860-iqk1yiw4	175	11	(	(	-LRB-
cord-307860-iqk1yiw4	175	12	ATP	ATP	NNP
cord-307860-iqk1yiw4	175	13	)	)	-RRB-
cord-307860-iqk1yiw4	175	14	analog	analog	NN
cord-307860-iqk1yiw4	175	15	.	.	.
cord-307860-iqk1yiw4	176	1	Remdesivir	Remdesivir	NNP
cord-307860-iqk1yiw4	176	2	is	be	VBZ
cord-307860-iqk1yiw4	176	3	metabolized	metabolize	VBN
cord-307860-iqk1yiw4	176	4	into	into	IN
cord-307860-iqk1yiw4	176	5	the	the	DT
cord-307860-iqk1yiw4	176	6	active	active	JJ
cord-307860-iqk1yiw4	176	7	form	form	NN
cord-307860-iqk1yiw4	176	8	remdesivir	remdesivir	JJ
cord-307860-iqk1yiw4	176	9	-	-	HYPH
cord-307860-iqk1yiw4	176	10	triphosphate	triphosphate	NNP
cord-307860-iqk1yiw4	176	11	(	(	-LRB-
cord-307860-iqk1yiw4	176	12	remdesivir	remdesivir	NNP
cord-307860-iqk1yiw4	176	13	-	-	HYPH
cord-307860-iqk1yiw4	176	14	TP	TP	NNP
cord-307860-iqk1yiw4	176	15	)	)	-RRB-
cord-307860-iqk1yiw4	177	1	(	(	-LRB-
cord-307860-iqk1yiw4	177	2	NCI	NCI	NNP
cord-307860-iqk1yiw4	177	3	Thesaurus	Thesaurus	NNP
cord-307860-iqk1yiw4	177	4	GS-441524	GS-441524	NNS
cord-307860-iqk1yiw4	177	5	)	)	-RRB-
cord-307860-iqk1yiw4	177	6	.	.	.
cord-307860-iqk1yiw4	178	1	The	the	DT
cord-307860-iqk1yiw4	178	2	antiviral	antiviral	JJ
cord-307860-iqk1yiw4	178	3	activity	activity	NN
cord-307860-iqk1yiw4	178	4	of	of	IN
cord-307860-iqk1yiw4	178	5	the	the	DT
cord-307860-iqk1yiw4	178	6	remdesivir	remdesivir	NNP
cord-307860-iqk1yiw4	178	7	-	-	HYPH
cord-307860-iqk1yiw4	178	8	TP	TP	NNP
cord-307860-iqk1yiw4	178	9	consists	consist	VBZ
cord-307860-iqk1yiw4	178	10	of	of	IN
cord-307860-iqk1yiw4	178	11	the	the	DT
cord-307860-iqk1yiw4	178	12	competition	competition	NN
cord-307860-iqk1yiw4	178	13	with	with	IN
cord-307860-iqk1yiw4	178	14	ATP	ATP	NNP
cord-307860-iqk1yiw4	178	15	for	for	IN
cord-307860-iqk1yiw4	178	16	RNA	RNA	NNP
cord-307860-iqk1yiw4	178	17	incorporation	incorporation	NN
cord-307860-iqk1yiw4	178	18	thus	thus	RB
cord-307860-iqk1yiw4	178	19	inhibiting	inhibit	VBG
cord-307860-iqk1yiw4	178	20	viral	viral	JJ
cord-307860-iqk1yiw4	178	21	RdRp	RdRp	NNP
cord-307860-iqk1yiw4	178	22	.	.	.
cord-307860-iqk1yiw4	179	1	Remdesivir	Remdesivir	NNP
cord-307860-iqk1yiw4	179	2	is	be	VBZ
cord-307860-iqk1yiw4	179	3	a	a	DT
cord-307860-iqk1yiw4	179	4	valuable	valuable	JJ
cord-307860-iqk1yiw4	179	5	therapeutic	therapeutic	JJ
cord-307860-iqk1yiw4	179	6	agent	agent	NN
cord-307860-iqk1yiw4	179	7	against	against	IN
cord-307860-iqk1yiw4	179	8	Ebola	Ebola	NNP
cord-307860-iqk1yiw4	179	9	virus	virus	NN
cord-307860-iqk1yiw4	179	10	infections	infection	NNS
cord-307860-iqk1yiw4	179	11	[	[	-LRB-
cord-307860-iqk1yiw4	179	12	73	73	CD
cord-307860-iqk1yiw4	179	13	]	]	-RRB-
cord-307860-iqk1yiw4	179	14	.	.	.
cord-307860-iqk1yiw4	180	1	Many	many	JJ
cord-307860-iqk1yiw4	180	2	studies	study	NNS
cord-307860-iqk1yiw4	180	3	investigated	investigate	VBD
cord-307860-iqk1yiw4	180	4	the	the	DT
cord-307860-iqk1yiw4	180	5	potential	potential	JJ
cord-307860-iqk1yiw4	180	6	therapeutic	therapeutic	JJ
cord-307860-iqk1yiw4	180	7	use	use	NN
cord-307860-iqk1yiw4	180	8	of	of	IN
cord-307860-iqk1yiw4	180	9	remdesivir	remdesivir	NNP
cord-307860-iqk1yiw4	180	10	against	against	IN
cord-307860-iqk1yiw4	180	11	other	other	JJ
cord-307860-iqk1yiw4	180	12	viral	viral	JJ
cord-307860-iqk1yiw4	180	13	infections	infection	NNS
cord-307860-iqk1yiw4	180	14	including	include	VBG
cord-307860-iqk1yiw4	180	15	COVID-19	covid-19	VB
cord-307860-iqk1yiw4	180	16	[	[	-LRB-
cord-307860-iqk1yiw4	180	17	74	74	CD
cord-307860-iqk1yiw4	180	18	]	]	-RRB-
cord-307860-iqk1yiw4	180	19	[	[	-LRB-
cord-307860-iqk1yiw4	180	20	75	75	CD
cord-307860-iqk1yiw4	180	21	]	]	-RRB-
cord-307860-iqk1yiw4	180	22	[	[	-LRB-
cord-307860-iqk1yiw4	180	23	76	76	CD
cord-307860-iqk1yiw4	180	24	]	]	-RRB-
cord-307860-iqk1yiw4	180	25	[	[	-LRB-
cord-307860-iqk1yiw4	180	26	77	77	CD
cord-307860-iqk1yiw4	180	27	]	]	-RRB-
cord-307860-iqk1yiw4	180	28	.	.	.
cord-307860-iqk1yiw4	181	1	The	the	DT
cord-307860-iqk1yiw4	181	2	therapeutic	therapeutic	JJ
cord-307860-iqk1yiw4	181	3	potency	potency	NN
cord-307860-iqk1yiw4	181	4	of	of	IN
cord-307860-iqk1yiw4	181	5	the	the	DT
cord-307860-iqk1yiw4	181	6	remdesivir	remdesivir	NNP
cord-307860-iqk1yiw4	181	7	in	in	IN
cord-307860-iqk1yiw4	181	8	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	181	9	needs	need	VBZ
cord-307860-iqk1yiw4	181	10	much	much	RB
cord-307860-iqk1yiw4	181	11	more	more	RBR
cord-307860-iqk1yiw4	181	12	well	well	RB
cord-307860-iqk1yiw4	181	13	-	-	HYPH
cord-307860-iqk1yiw4	181	14	conducted	conduct	VBN
cord-307860-iqk1yiw4	181	15	studies	study	NNS
cord-307860-iqk1yiw4	181	16	and	and	CC
cord-307860-iqk1yiw4	181	17	a	a	DT
cord-307860-iqk1yiw4	181	18	thorough	thorough	JJ
cord-307860-iqk1yiw4	181	19	analysis	analysis	NN
cord-307860-iqk1yiw4	181	20	of	of	IN
cord-307860-iqk1yiw4	181	21	the	the	DT
cord-307860-iqk1yiw4	181	22	clinical	clinical	JJ
cord-307860-iqk1yiw4	181	23	results	result	NNS
cord-307860-iqk1yiw4	181	24	[	[	-LRB-
cord-307860-iqk1yiw4	181	25	78	78	CD
cord-307860-iqk1yiw4	181	26	]	]	-RRB-
cord-307860-iqk1yiw4	181	27	.	.	.
cord-307860-iqk1yiw4	182	1	The	the	DT
cord-307860-iqk1yiw4	183	1	SARS	SARS	NNP
cord-307860-iqk1yiw4	183	2	-	-	HYPH
cord-307860-iqk1yiw4	183	3	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	183	4	RdRp	RdRp	NNP
cord-307860-iqk1yiw4	183	5	structure	structure	NN
cord-307860-iqk1yiw4	183	6	provides	provide	VBZ
cord-307860-iqk1yiw4	183	7	important	important	JJ
cord-307860-iqk1yiw4	183	8	structural	structural	JJ
cord-307860-iqk1yiw4	183	9	details	detail	NNS
cord-307860-iqk1yiw4	183	10	about	about	IN
cord-307860-iqk1yiw4	183	11	RdRp	RdRp	NNP
cord-307860-iqk1yiw4	183	12	-RNA	-rna	PRP$
cord-307860-iqk1yiw4	183	13	interactions	interaction	NNS
cord-307860-iqk1yiw4	183	14	(	(	-LRB-
cord-307860-iqk1yiw4	183	15	PDB	PDB	NNP
cord-307860-iqk1yiw4	183	16	ID(s	ID(s	NNP
cord-307860-iqk1yiw4	183	17	)	)	-RRB-
cord-307860-iqk1yiw4	183	18	6YYT	6yyt	CD
cord-307860-iqk1yiw4	183	19	,	,	,
cord-307860-iqk1yiw4	183	20	7BTF	7BTF	NNP
cord-307860-iqk1yiw4	183	21	,	,	,
cord-307860-iqk1yiw4	183	22	6M71	6m71	CD
cord-307860-iqk1yiw4	183	23	,	,	,
cord-307860-iqk1yiw4	183	24	and	and	CC
cord-307860-iqk1yiw4	183	25	7BV1	7bv1	LS
cord-307860-iqk1yiw4	183	26	)	)	-RRB-
cord-307860-iqk1yiw4	183	27	[	[	-LRB-
cord-307860-iqk1yiw4	183	28	31	31	CD
cord-307860-iqk1yiw4	183	29	,	,	,
cord-307860-iqk1yiw4	183	30	37	37	CD
cord-307860-iqk1yiw4	183	31	,	,	,
cord-307860-iqk1yiw4	183	32	38	38	CD
cord-307860-iqk1yiw4	183	33	]	]	-RRB-
cord-307860-iqk1yiw4	183	34	.	.	.
cord-307860-iqk1yiw4	184	1	The	the	DT
cord-307860-iqk1yiw4	184	2	structures	structure	NNS
cord-307860-iqk1yiw4	184	3	co	co	VBD
cord-307860-iqk1yiw4	184	4	-	-	VBD
cord-307860-iqk1yiw4	184	5	crystallized	crystallize	VBN
cord-307860-iqk1yiw4	184	6	with	with	IN
cord-307860-iqk1yiw4	184	7	remdesivir	remdesivir	NNP
cord-307860-iqk1yiw4	184	8	further	further	RB
cord-307860-iqk1yiw4	184	9	advances	advance	VBZ
cord-307860-iqk1yiw4	184	10	the	the	DT
cord-307860-iqk1yiw4	184	11	understanding	understanding	NN
cord-307860-iqk1yiw4	184	12	of	of	IN
cord-307860-iqk1yiw4	184	13	the	the	DT
cord-307860-iqk1yiw4	184	14	mechanisms	mechanism	NNS
cord-307860-iqk1yiw4	184	15	of	of	IN
cord-307860-iqk1yiw4	184	16	viral	viral	JJ
cord-307860-iqk1yiw4	184	17	RNA	RNA	NNP
cord-307860-iqk1yiw4	184	18	replication	replication	NN
cord-307860-iqk1yiw4	184	19	(	(	-LRB-
cord-307860-iqk1yiw4	184	20	PDB	PDB	NNP
cord-307860-iqk1yiw4	184	21	ID	ID	NNP
cord-307860-iqk1yiw4	184	22	7BV2	7bv2	CD
cord-307860-iqk1yiw4	184	23	)	)	-RRB-
cord-307860-iqk1yiw4	184	24	[	[	-LRB-
cord-307860-iqk1yiw4	184	25	37	37	CD
cord-307860-iqk1yiw4	184	26	]	]	-RRB-
cord-307860-iqk1yiw4	184	27	.	.	.
cord-307860-iqk1yiw4	185	1	Yin	Yin	NNP
cord-307860-iqk1yiw4	185	2	et	et	NNP
cord-307860-iqk1yiw4	185	3	al	al	NNP
cord-307860-iqk1yiw4	185	4	.	.	.
cord-307860-iqk1yiw4	186	1	demonstrates	demonstrate	VBZ
cord-307860-iqk1yiw4	186	2	that	that	IN
cord-307860-iqk1yiw4	186	3	RdRp	RdRp	NNP
cord-307860-iqk1yiw4	186	4	inhibition	inhibition	NN
cord-307860-iqk1yiw4	186	5	depends	depend	VBZ
cord-307860-iqk1yiw4	186	6	on	on	IN
cord-307860-iqk1yiw4	186	7	the	the	DT
cord-307860-iqk1yiw4	186	8	low	low	JJ
cord-307860-iqk1yiw4	186	9	remdesivir	remdesivir	NN
cord-307860-iqk1yiw4	186	10	-	-	HYPH
cord-307860-iqk1yiw4	186	11	triphosphate	triphosphate	NNP
cord-307860-iqk1yiw4	186	12	(	(	-LRB-
cord-307860-iqk1yiw4	186	13	RTP	RTP	NNP
cord-307860-iqk1yiw4	186	14	)	)	-RRB-
cord-307860-iqk1yiw4	186	15	concentration	concentration	NN
cord-307860-iqk1yiw4	186	16	and	and	CC
cord-307860-iqk1yiw4	186	17	low	low	JJ
cord-307860-iqk1yiw4	186	18	RTP	RTP	NNP
cord-307860-iqk1yiw4	186	19	/	/	SYM
cord-307860-iqk1yiw4	186	20	ATP	ATP	NNP
cord-307860-iqk1yiw4	186	21	ratio	ratio	NN
cord-307860-iqk1yiw4	186	22	.	.	.
cord-307860-iqk1yiw4	187	1	Only	only	RB
cord-307860-iqk1yiw4	187	2	RTP	RTP	NNP
cord-307860-iqk1yiw4	187	3	inhibits	inhibit	VBZ
cord-307860-iqk1yiw4	187	4	the	the	DT
cord-307860-iqk1yiw4	187	5	RdRp	RdRp	NNP
cord-307860-iqk1yiw4	187	6	polymerization	polymerization	NN
cord-307860-iqk1yiw4	187	7	activity	activity	NN
cord-307860-iqk1yiw4	187	8	.	.	.
cord-307860-iqk1yiw4	188	1	The	the	DT
cord-307860-iqk1yiw4	188	2	structural	structural	JJ
cord-307860-iqk1yiw4	188	3	studies	study	NNS
cord-307860-iqk1yiw4	188	4	have	have	VBP
cord-307860-iqk1yiw4	188	5	shown	show	VBN
cord-307860-iqk1yiw4	188	6	that	that	IN
cord-307860-iqk1yiw4	188	7	the	the	DT
cord-307860-iqk1yiw4	188	8	Asn691	asn691	NN
cord-307860-iqk1yiw4	188	9	,	,	,
cord-307860-iqk1yiw4	188	10	Ser682	Ser682	NNP
cord-307860-iqk1yiw4	188	11	,	,	,
cord-307860-iqk1yiw4	188	12	and	and	CC
cord-307860-iqk1yiw4	188	13	Asp623	asp623	ADD
cord-307860-iqk1yiw4	188	14	in	in	IN
cord-307860-iqk1yiw4	188	15	the	the	DT
cord-307860-iqk1yiw4	188	16	RdRp	RdRp	NNP
cord-307860-iqk1yiw4	188	17	complex	complex	NN
cord-307860-iqk1yiw4	188	18	explain	explain	VBP
cord-307860-iqk1yiw4	188	19	the	the	DT
cord-307860-iqk1yiw4	188	20	binding	binding	NN
cord-307860-iqk1yiw4	188	21	of	of	IN
cord-307860-iqk1yiw4	188	22	the	the	DT
cord-307860-iqk1yiw4	188	23	RTP	RTP	NNP
cord-307860-iqk1yiw4	188	24	to	to	IN
cord-307860-iqk1yiw4	188	25	the	the	DT
cord-307860-iqk1yiw4	188	26	NTPs	ntp	NNS
cord-307860-iqk1yiw4	188	27	site	site	NN
cord-307860-iqk1yiw4	188	28	[	[	-LRB-
cord-307860-iqk1yiw4	188	29	38	38	CD
cord-307860-iqk1yiw4	188	30	]	]	-RRB-
cord-307860-iqk1yiw4	188	31	.	.	.
cord-307860-iqk1yiw4	189	1	However	however	RB
cord-307860-iqk1yiw4	189	2	,	,	,
cord-307860-iqk1yiw4	189	3	the	the	DT
cord-307860-iqk1yiw4	189	4	structural	structural	JJ
cord-307860-iqk1yiw4	189	5	studies	study	NNS
cord-307860-iqk1yiw4	189	6	should	should	MD
cord-307860-iqk1yiw4	189	7	be	be	VB
cord-307860-iqk1yiw4	189	8	interpreted	interpret	VBN
cord-307860-iqk1yiw4	189	9	according	accord	VBG
cord-307860-iqk1yiw4	189	10	to	to	IN
cord-307860-iqk1yiw4	189	11	biochemical	biochemical	JJ
cord-307860-iqk1yiw4	189	12	studies	study	NNS
cord-307860-iqk1yiw4	189	13	to	to	TO
cord-307860-iqk1yiw4	189	14	further	further	RB
cord-307860-iqk1yiw4	189	15	elucidate	elucidate	VB
cord-307860-iqk1yiw4	189	16	the	the	DT
cord-307860-iqk1yiw4	189	17	incorporation	incorporation	NN
cord-307860-iqk1yiw4	189	18	of	of	IN
cord-307860-iqk1yiw4	189	19	RTP	RTP	NNP
cord-307860-iqk1yiw4	189	20	into	into	IN
cord-307860-iqk1yiw4	189	21	the	the	DT
cord-307860-iqk1yiw4	189	22	growing	grow	VBG
cord-307860-iqk1yiw4	189	23	RNA	RNA	NNP
cord-307860-iqk1yiw4	189	24	chain	chain	NN
cord-307860-iqk1yiw4	189	25	[	[	-LRB-
cord-307860-iqk1yiw4	189	26	38	38	CD
cord-307860-iqk1yiw4	189	27	,	,	,
cord-307860-iqk1yiw4	189	28	77	77	CD
cord-307860-iqk1yiw4	189	29	,	,	,
cord-307860-iqk1yiw4	189	30	79	79	CD
cord-307860-iqk1yiw4	189	31	,	,	,
cord-307860-iqk1yiw4	189	32	80	80	CD
cord-307860-iqk1yiw4	189	33	]	]	-RRB-
cord-307860-iqk1yiw4	189	34	.	.	.
cord-307860-iqk1yiw4	190	1	The	the	DT
cord-307860-iqk1yiw4	190	2	recent	recent	JJ
cord-307860-iqk1yiw4	190	3	structural	structural	JJ
cord-307860-iqk1yiw4	190	4	works	work	NNS
cord-307860-iqk1yiw4	190	5	provide	provide	VBP
cord-307860-iqk1yiw4	190	6	insight	insight	NN
cord-307860-iqk1yiw4	190	7	into	into	IN
cord-307860-iqk1yiw4	190	8	the	the	DT
cord-307860-iqk1yiw4	190	9	nucleotide	nucleotide	JJ
cord-307860-iqk1yiw4	190	10	analog	analog	NN
cord-307860-iqk1yiw4	190	11	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	190	12	'	'	POS
cord-307860-iqk1yiw4	190	13	ability	ability	NN
cord-307860-iqk1yiw4	190	14	to	to	TO
cord-307860-iqk1yiw4	190	15	hamper	hamper	VB
cord-307860-iqk1yiw4	190	16	SARS	SARS	NNP
cord-307860-iqk1yiw4	190	17	-	-	HYPH
cord-307860-iqk1yiw4	190	18	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	190	19	RNA	RNA	NNP
cord-307860-iqk1yiw4	190	20	replication	replication	NN
cord-307860-iqk1yiw4	190	21	.	.	.
cord-307860-iqk1yiw4	191	1	The	the	DT
cord-307860-iqk1yiw4	191	2	pre	pre	JJ
cord-307860-iqk1yiw4	191	3	-	-	JJ
cord-307860-iqk1yiw4	191	4	translocated	translocated	JJ
cord-307860-iqk1yiw4	191	5	and	and	CC
cord-307860-iqk1yiw4	191	6	post	post	JJ
cord-307860-iqk1yiw4	191	7	-	-	JJ
cord-307860-iqk1yiw4	191	8	translocated	translocated	JJ
cord-307860-iqk1yiw4	191	9	RdRp	RdRp	NNP
cord-307860-iqk1yiw4	191	10	complex	complex	JJ
cord-307860-iqk1yiw4	191	11	structures	structure	NNS
cord-307860-iqk1yiw4	191	12	(	(	-LRB-
cord-307860-iqk1yiw4	191	13	PDB	PDB	NNP
cord-307860-iqk1yiw4	191	14	ID(s	ID(s	NNP
cord-307860-iqk1yiw4	191	15	)	)	-RRB-
cord-307860-iqk1yiw4	191	16	7C2	7c2	CD
cord-307860-iqk1yiw4	191	17	K	K	NNP
cord-307860-iqk1yiw4	191	18	and	and	CC
cord-307860-iqk1yiw4	191	19	7BZF	7bzf	LS
cord-307860-iqk1yiw4	191	20	)	)	-RRB-
cord-307860-iqk1yiw4	191	21	show	show	VBP
cord-307860-iqk1yiw4	191	22	that	that	IN
cord-307860-iqk1yiw4	191	23	an	an	DT
cord-307860-iqk1yiw4	191	24	efficient	efficient	JJ
cord-307860-iqk1yiw4	191	25	inhibitory	inhibitory	JJ
cord-307860-iqk1yiw4	191	26	strategy	strategy	NN
cord-307860-iqk1yiw4	191	27	could	could	MD
cord-307860-iqk1yiw4	191	28	be	be	VB
cord-307860-iqk1yiw4	191	29	the	the	DT
cord-307860-iqk1yiw4	191	30	blocking	blocking	NN
cord-307860-iqk1yiw4	191	31	of	of	IN
cord-307860-iqk1yiw4	191	32	the	the	DT
cord-307860-iqk1yiw4	191	33	interaction	interaction	NN
cord-307860-iqk1yiw4	191	34	between	between	IN
cord-307860-iqk1yiw4	191	35	nsp8	nsp8	NN
cord-307860-iqk1yiw4	191	36	and	and	CC
cord-307860-iqk1yiw4	191	37	nsp12	nsp12	CD
cord-307860-iqk1yiw4	191	38	[	[	-LRB-
cord-307860-iqk1yiw4	191	39	45	45	CD
cord-307860-iqk1yiw4	191	40	]	]	-RRB-
cord-307860-iqk1yiw4	191	41	.	.	.
cord-307860-iqk1yiw4	192	1	The	the	DT
cord-307860-iqk1yiw4	192	2	biochemical	biochemical	JJ
cord-307860-iqk1yiw4	192	3	and	and	CC
cord-307860-iqk1yiw4	192	4	structural	structural	JJ
cord-307860-iqk1yiw4	192	5	works	work	NNS
cord-307860-iqk1yiw4	192	6	of	of	IN
cord-307860-iqk1yiw4	192	7	Peng	Peng	NNP
cord-307860-iqk1yiw4	192	8	et	et	NNP
cord-307860-iqk1yiw4	192	9	al	al	NNP
cord-307860-iqk1yiw4	192	10	.	.	.
cord-307860-iqk1yiw4	193	1	(	(	-LRB-
cord-307860-iqk1yiw4	193	2	PDB	PDB	NNP
cord-307860-iqk1yiw4	193	3	ID	ID	NNP
cord-307860-iqk1yiw4	193	4	7BW4	7bw4	CD
cord-307860-iqk1yiw4	193	5	)	)	-RRB-
cord-307860-iqk1yiw4	193	6	demonstrate	demonstrate	VBP
cord-307860-iqk1yiw4	193	7	that	that	IN
cord-307860-iqk1yiw4	193	8	SARS	SARS	NNP
cord-307860-iqk1yiw4	193	9	-	-	HYPH
cord-307860-iqk1yiw4	193	10	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	193	11	RdRp	RdRp	NNP
cord-307860-iqk1yiw4	193	12	enzymatic	enzymatic	JJ
cord-307860-iqk1yiw4	193	13	activity	activity	NN
cord-307860-iqk1yiw4	193	14	is	be	VBZ
cord-307860-iqk1yiw4	193	15	lower	low	JJR
cord-307860-iqk1yiw4	193	16	,	,	,
cord-307860-iqk1yiw4	193	17	about	about	RB
cord-307860-iqk1yiw4	193	18	35	35	CD
cord-307860-iqk1yiw4	193	19	%	%	NN
cord-307860-iqk1yiw4	193	20	for	for	IN
cord-307860-iqk1yiw4	193	21	RNA	rna	NN
cord-307860-iqk1yiw4	193	22	synthesis	synthesis	NN
cord-307860-iqk1yiw4	193	23	than	than	IN
cord-307860-iqk1yiw4	193	24	its	-PRON-	PRP$
cord-307860-iqk1yiw4	193	25	SARS	SARS	NNP
cord-307860-iqk1yiw4	193	26	-	-	HYPH
cord-307860-iqk1yiw4	193	27	CoV	CoV	NNP
cord-307860-iqk1yiw4	193	28	counterpart	counterpart	NN
cord-307860-iqk1yiw4	193	29	.	.	.
cord-307860-iqk1yiw4	194	1	The	the	DT
cord-307860-iqk1yiw4	194	2	reason	reason	NN
cord-307860-iqk1yiw4	194	3	is	be	VBZ
cord-307860-iqk1yiw4	194	4	the	the	DT
cord-307860-iqk1yiw4	194	5	residue	residue	JJ
cord-307860-iqk1yiw4	194	6	substitution	substitution	NN
cord-307860-iqk1yiw4	194	7	in	in	IN
cord-307860-iqk1yiw4	194	8	nsp12	nsp12	CD
cord-307860-iqk1yiw4	194	9	and	and	CC
cord-307860-iqk1yiw4	194	10	nsp8	nsp8	NN
cord-307860-iqk1yiw4	194	11	.	.	.
cord-307860-iqk1yiw4	195	1	Also	also	RB
cord-307860-iqk1yiw4	195	2	,	,	,
cord-307860-iqk1yiw4	195	3	the	the	DT
cord-307860-iqk1yiw4	195	4	thermal	thermal	JJ
cord-307860-iqk1yiw4	195	5	stability	stability	NN
cord-307860-iqk1yiw4	195	6	of	of	IN
cord-307860-iqk1yiw4	195	7	the	the	DT
cord-307860-iqk1yiw4	195	8	SARS	SARS	NNP
cord-307860-iqk1yiw4	195	9	-	-	HYPH
cord-307860-iqk1yiw4	195	10	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	195	11	RdRp	RdRp	NNP
cord-307860-iqk1yiw4	195	12	is	be	VBZ
cord-307860-iqk1yiw4	195	13	lower	low	JJR
cord-307860-iqk1yiw4	195	14	compared	compare	VBN
cord-307860-iqk1yiw4	195	15	to	to	IN
cord-307860-iqk1yiw4	195	16	that	that	DT
cord-307860-iqk1yiw4	195	17	of	of	IN
cord-307860-iqk1yiw4	195	18	SARS	SARS	NNP
cord-307860-iqk1yiw4	195	19	-	-	HYPH
cord-307860-iqk1yiw4	195	20	CoV	CoV	NNP
cord-307860-iqk1yiw4	195	21	RdRp	RdRp	NNP
cord-307860-iqk1yiw4	196	1	The	the	DT
cord-307860-iqk1yiw4	196	2	thermal	thermal	JJ
cord-307860-iqk1yiw4	196	3	stability	stability	NN
cord-307860-iqk1yiw4	196	4	of	of	IN
cord-307860-iqk1yiw4	196	5	RdRp	RdRp	NNP
cord-307860-iqk1yiw4	196	6	could	could	MD
cord-307860-iqk1yiw4	196	7	advance	advance	VB
cord-307860-iqk1yiw4	196	8	the	the	DT
cord-307860-iqk1yiw4	196	9	understanding	understanding	NN
cord-307860-iqk1yiw4	196	10	of	of	IN
cord-307860-iqk1yiw4	196	11	the	the	DT
cord-307860-iqk1yiw4	196	12	adaptive	adaptive	JJ
cord-307860-iqk1yiw4	196	13	evolution	evolution	NN
cord-307860-iqk1yiw4	196	14	of	of	IN
cord-307860-iqk1yiw4	196	15	SARS	SARS	NNP
cord-307860-iqk1yiw4	196	16	-	-	HYPH
cord-307860-iqk1yiw4	196	17	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	196	18	in	in	IN
cord-307860-iqk1yiw4	196	19	the	the	DT
cord-307860-iqk1yiw4	196	20	human	human	JJ
cord-307860-iqk1yiw4	196	21	host	host	NN
cord-307860-iqk1yiw4	196	22	that	that	WDT
cord-307860-iqk1yiw4	196	23	have	have	VBP
cord-307860-iqk1yiw4	196	24	a	a	DT
cord-307860-iqk1yiw4	196	25	lower	low	JJR
cord-307860-iqk1yiw4	196	26	body	body	NN
cord-307860-iqk1yiw4	196	27	temperature	temperature	NN
cord-307860-iqk1yiw4	196	28	than	than	IN
cord-307860-iqk1yiw4	196	29	bats	bat	NNS
cord-307860-iqk1yiw4	196	30	[	[	-LRB-
cord-307860-iqk1yiw4	196	31	3	3	CD
cord-307860-iqk1yiw4	196	32	,	,	,
cord-307860-iqk1yiw4	196	33	48	48	CD
cord-307860-iqk1yiw4	196	34	,	,	,
cord-307860-iqk1yiw4	196	35	81	81	CD
cord-307860-iqk1yiw4	196	36	]	]	-RRB-
cord-307860-iqk1yiw4	196	37	.	.	.
cord-307860-iqk1yiw4	197	1	The	the	DT
cord-307860-iqk1yiw4	197	2	papain	papain	NN
cord-307860-iqk1yiw4	197	3	-	-	HYPH
cord-307860-iqk1yiw4	197	4	like	like	JJ
cord-307860-iqk1yiw4	197	5	protease	protease	NN
cord-307860-iqk1yiw4	197	6	(	(	-LRB-
cord-307860-iqk1yiw4	197	7	PL	pl	NN
cord-307860-iqk1yiw4	197	8	pro	pro	FW
cord-307860-iqk1yiw4	197	9	)	)	-RRB-
cord-307860-iqk1yiw4	197	10	is	be	VBZ
cord-307860-iqk1yiw4	197	11	a	a	DT
cord-307860-iqk1yiw4	197	12	cysteine	cysteine	NN
cord-307860-iqk1yiw4	197	13	protease	protease	NN
cord-307860-iqk1yiw4	197	14	.	.	.
cord-307860-iqk1yiw4	198	1	PL	PL	NNP
cord-307860-iqk1yiw4	198	2	pro	pro	NNP
cord-307860-iqk1yiw4	198	3	,	,	,
cord-307860-iqk1yiw4	198	4	RNA	RNA	NNP
cord-307860-iqk1yiw4	198	5	binding	binding	NN
cord-307860-iqk1yiw4	198	6	domain	domain	NN
cord-307860-iqk1yiw4	198	7	,	,	,
cord-307860-iqk1yiw4	198	8	and	and	CC
cord-307860-iqk1yiw4	198	9	membrane	membrane	NN
cord-307860-iqk1yiw4	198	10	-	-	HYPH
cord-307860-iqk1yiw4	198	11	anchoring	anchor	VBG
cord-307860-iqk1yiw4	198	12	domain	domain	NN
cord-307860-iqk1yiw4	198	13	form	form	VBP
cord-307860-iqk1yiw4	198	14	the	the	DT
cord-307860-iqk1yiw4	198	15	non	non	JJ
cord-307860-iqk1yiw4	198	16	-	-	JJ
cord-307860-iqk1yiw4	198	17	structural	structural	JJ
cord-307860-iqk1yiw4	198	18	protein	protein	NN
cord-307860-iqk1yiw4	198	19	3	3	CD
cord-307860-iqk1yiw4	198	20	(	(	-LRB-
cord-307860-iqk1yiw4	198	21	nsp3	nsp3	NNS
cord-307860-iqk1yiw4	198	22	)	)	-RRB-
cord-307860-iqk1yiw4	198	23	.	.	.
cord-307860-iqk1yiw4	199	1	PL	PL	NNP
cord-307860-iqk1yiw4	199	2	pro	pro	RB
cord-307860-iqk1yiw4	199	3	from	from	IN
cord-307860-iqk1yiw4	199	4	different	different	JJ
cord-307860-iqk1yiw4	199	5	HCoVs	HCoVs	NNP
cord-307860-iqk1yiw4	199	6	has	have	VBZ
cord-307860-iqk1yiw4	199	7	been	be	VBN
cord-307860-iqk1yiw4	199	8	screened	screen	VBN
cord-307860-iqk1yiw4	199	9	for	for	IN
cord-307860-iqk1yiw4	199	10	a	a	DT
cord-307860-iqk1yiw4	199	11	large	large	JJ
cord-307860-iqk1yiw4	199	12	panel	panel	NN
cord-307860-iqk1yiw4	199	13	of	of	IN
cord-307860-iqk1yiw4	199	14	chemicals	chemical	NNS
cord-307860-iqk1yiw4	199	15	because	because	IN
cord-307860-iqk1yiw4	199	16	it	-PRON-	PRP
cord-307860-iqk1yiw4	199	17	is	be	VBZ
cord-307860-iqk1yiw4	199	18	involved	involve	VBN
cord-307860-iqk1yiw4	199	19	in	in	IN
cord-307860-iqk1yiw4	199	20	CoV	cov	NN
cord-307860-iqk1yiw4	199	21	replication	replication	NN
cord-307860-iqk1yiw4	199	22	[	[	-LRB-
cord-307860-iqk1yiw4	199	23	82	82	CD
cord-307860-iqk1yiw4	199	24	,	,	,
cord-307860-iqk1yiw4	199	25	83	83	CD
cord-307860-iqk1yiw4	199	26	]	]	-RRB-
cord-307860-iqk1yiw4	199	27	.	.	.
cord-307860-iqk1yiw4	200	1	The	the	DT
cord-307860-iqk1yiw4	200	2	biochemical	biochemical	JJ
cord-307860-iqk1yiw4	200	3	,	,	,
cord-307860-iqk1yiw4	200	4	structural	structural	JJ
cord-307860-iqk1yiw4	200	5	,	,	,
cord-307860-iqk1yiw4	200	6	and	and	CC
cord-307860-iqk1yiw4	200	7	functional	functional	JJ
cord-307860-iqk1yiw4	200	8	studies	study	NNS
cord-307860-iqk1yiw4	200	9	advance	advance	VBP
cord-307860-iqk1yiw4	200	10	the	the	DT
cord-307860-iqk1yiw4	200	11	development	development	NN
cord-307860-iqk1yiw4	200	12	of	of	IN
cord-307860-iqk1yiw4	200	13	new	new	JJ
cord-307860-iqk1yiw4	200	14	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	200	15	against	against	IN
cord-307860-iqk1yiw4	200	16	SARS	SARS	NNP
cord-307860-iqk1yiw4	200	17	-	-	HYPH
cord-307860-iqk1yiw4	200	18	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	200	19	PL	PL	NNP
cord-307860-iqk1yiw4	200	20	pro	pro	NN
cord-307860-iqk1yiw4	200	21	.	.	.
cord-307860-iqk1yiw4	201	1	The	the	DT
cord-307860-iqk1yiw4	201	2	naphthalene	naphthalene	NN
cord-307860-iqk1yiw4	201	3	-	-	HYPH
cord-307860-iqk1yiw4	201	4	based	base	VBN
cord-307860-iqk1yiw4	201	5	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	201	6	GRL-0617	grl-0617	XX
cord-307860-iqk1yiw4	202	1	(	(	-LRB-
cord-307860-iqk1yiw4	202	2	PubChem	PubChem	NNP
cord-307860-iqk1yiw4	202	3	CID	CID	NNP
cord-307860-iqk1yiw4	202	4	44828571	44828571	CD
cord-307860-iqk1yiw4	202	5	)	)	-RRB-
cord-307860-iqk1yiw4	202	6	is	be	VBZ
cord-307860-iqk1yiw4	202	7	an	an	DT
cord-307860-iqk1yiw4	202	8	effective	effective	JJ
cord-307860-iqk1yiw4	202	9	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	202	10	of	of	IN
cord-307860-iqk1yiw4	202	11	the	the	DT
cord-307860-iqk1yiw4	202	12	SARS	SARS	NNP
cord-307860-iqk1yiw4	202	13	-	-	HYPH
cord-307860-iqk1yiw4	202	14	CoV	CoV	NNP
cord-307860-iqk1yiw4	202	15	PL	pl	NN
cord-307860-iqk1yiw4	202	16	pro	pro	JJ
cord-307860-iqk1yiw4	202	17	(	(	-LRB-
cord-307860-iqk1yiw4	202	18	Table	table	NN
cord-307860-iqk1yiw4	202	19	1	1	CD
cord-307860-iqk1yiw4	202	20	)	)	-RRB-
cord-307860-iqk1yiw4	203	1	[	[	-LRB-
cord-307860-iqk1yiw4	203	2	84	84	CD
cord-307860-iqk1yiw4	203	3	]	]	-RRB-
cord-307860-iqk1yiw4	203	4	.	.	.
cord-307860-iqk1yiw4	204	1	Shin	Shin	NNP
cord-307860-iqk1yiw4	204	2	et	et	NNP
cord-307860-iqk1yiw4	204	3	al	al	NNP
cord-307860-iqk1yiw4	204	4	.	.	.
cord-307860-iqk1yiw4	205	1	advances	advance	VBZ
cord-307860-iqk1yiw4	205	2	the	the	DT
cord-307860-iqk1yiw4	205	3	hypothesis	hypothesis	NN
cord-307860-iqk1yiw4	205	4	that	that	IN
cord-307860-iqk1yiw4	205	5	the	the	DT
cord-307860-iqk1yiw4	205	6	GRL-0617	GRL-0617	NNP
cord-307860-iqk1yiw4	205	7	has	have	VBZ
cord-307860-iqk1yiw4	205	8	two	two	CD
cord-307860-iqk1yiw4	205	9	effects	effect	NNS
cord-307860-iqk1yiw4	205	10	against	against	IN
cord-307860-iqk1yiw4	205	11	SARS	SARS	NNP
cord-307860-iqk1yiw4	205	12	-	-	HYPH
cord-307860-iqk1yiw4	205	13	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	205	14	PL	PL	NNP
cord-307860-iqk1yiw4	205	15	pro	pro	NN
cord-307860-iqk1yiw4	205	16	.	.	.
cord-307860-iqk1yiw4	206	1	First	first	RB
cord-307860-iqk1yiw4	206	2	,	,	,
cord-307860-iqk1yiw4	206	3	the	the	DT
cord-307860-iqk1yiw4	206	4	GRL-0617	grl-0617	JJ
cord-307860-iqk1yiw4	206	5	binding	binding	NN
cord-307860-iqk1yiw4	206	6	to	to	IN
cord-307860-iqk1yiw4	206	7	the	the	DT
cord-307860-iqk1yiw4	206	8	amino	amino	NN
cord-307860-iqk1yiw4	206	9	acid	acid	NN
cord-307860-iqk1yiw4	206	10	Y268	Y268	NNP
cord-307860-iqk1yiw4	206	11	was	be	VBD
cord-307860-iqk1yiw4	206	12	confirmed	confirm	VBN
cord-307860-iqk1yiw4	206	13	by	by	IN
cord-307860-iqk1yiw4	206	14	the	the	DT
cord-307860-iqk1yiw4	206	15	reduction	reduction	NN
cord-307860-iqk1yiw4	206	16	of	of	IN
cord-307860-iqk1yiw4	206	17	the	the	DT
cord-307860-iqk1yiw4	206	18	inhibitory	inhibitory	JJ
cord-307860-iqk1yiw4	206	19	effect	effect	NN
cord-307860-iqk1yiw4	206	20	in	in	IN
cord-307860-iqk1yiw4	206	21	mutated	mutate	VBN
cord-307860-iqk1yiw4	206	22	PL	pl	NN
cord-307860-iqk1yiw4	206	23	pro	pro	FW
cord-307860-iqk1yiw4	206	24	Y268	y268	FW
cord-307860-iqk1yiw4	206	25	T	t	NN
cord-307860-iqk1yiw4	206	26	and	and	CC
cord-307860-iqk1yiw4	206	27	Y268G.	Y268G.	NNP
cord-307860-iqk1yiw4	206	28	Second	Second	NNP
cord-307860-iqk1yiw4	206	29	,	,	,
cord-307860-iqk1yiw4	206	30	the	the	DT
cord-307860-iqk1yiw4	206	31	GRL-0617	GRL-0617	NNP
cord-307860-iqk1yiw4	206	32	promotes	promote	VBZ
cord-307860-iqk1yiw4	206	33	the	the	DT
cord-307860-iqk1yiw4	206	34	antiviral	antiviral	JJ
cord-307860-iqk1yiw4	206	35	interferon	interferon	NN
cord-307860-iqk1yiw4	206	36	pathway	pathway	NN
cord-307860-iqk1yiw4	206	37	and	and	CC
cord-307860-iqk1yiw4	206	38	reduces	reduce	VBZ
cord-307860-iqk1yiw4	206	39	viral	viral	JJ
cord-307860-iqk1yiw4	206	40	replication	replication	NN
cord-307860-iqk1yiw4	206	41	(	(	-LRB-
cord-307860-iqk1yiw4	206	42	PDB	PDB	NNP
cord-307860-iqk1yiw4	206	43	ID	ID	NNP
cord-307860-iqk1yiw4	206	44	6YVA	6YVA	NNP
cord-307860-iqk1yiw4	206	45	)	)	-RRB-
cord-307860-iqk1yiw4	207	1	[	[	-LRB-
cord-307860-iqk1yiw4	207	2	50	50	CD
cord-307860-iqk1yiw4	207	3	]	]	-RRB-
cord-307860-iqk1yiw4	207	4	.	.	.
cord-307860-iqk1yiw4	207	5	 	 	_SP
cord-307860-iqk1yiw4	208	1	The	the	DT
cord-307860-iqk1yiw4	208	2	CoV	cov	NN
cord-307860-iqk1yiw4	208	3	nucleocapsid	nucleocapsid	NN
cord-307860-iqk1yiw4	208	4	(	(	-LRB-
cord-307860-iqk1yiw4	208	5	N	N	NNP
cord-307860-iqk1yiw4	208	6	)	)	-RRB-
cord-307860-iqk1yiw4	208	7	is	be	VBZ
cord-307860-iqk1yiw4	208	8	a	a	DT
cord-307860-iqk1yiw4	208	9	highly	highly	RB
cord-307860-iqk1yiw4	208	10	immunogenic	immunogenic	JJ
cord-307860-iqk1yiw4	208	11	multifunctional	multifunctional	JJ
cord-307860-iqk1yiw4	208	12	protein	protein	NN
cord-307860-iqk1yiw4	208	13	.	.	.
cord-307860-iqk1yiw4	209	1	The	the	DT
cord-307860-iqk1yiw4	209	2	CoV	cov	NN
cord-307860-iqk1yiw4	209	3	N	n	CD
cord-307860-iqk1yiw4	209	4	binds	bind	VBZ
cord-307860-iqk1yiw4	209	5	the	the	DT
cord-307860-iqk1yiw4	209	6	viral	viral	JJ
cord-307860-iqk1yiw4	209	7	RNA	RNA	NNP
cord-307860-iqk1yiw4	209	8	strand	strand	NN
cord-307860-iqk1yiw4	209	9	into	into	IN
cord-307860-iqk1yiw4	209	10	a	a	DT
cord-307860-iqk1yiw4	209	11	long	long	JJ
cord-307860-iqk1yiw4	209	12	helical	helical	JJ
cord-307860-iqk1yiw4	209	13	structure	structure	NN
cord-307860-iqk1yiw4	209	14	attached	attach	VBN
cord-307860-iqk1yiw4	209	15	to	to	IN
cord-307860-iqk1yiw4	209	16	the	the	DT
cord-307860-iqk1yiw4	209	17	membrane	membrane	NN
cord-307860-iqk1yiw4	209	18	(	(	-LRB-
cord-307860-iqk1yiw4	209	19	M	M	NNP
cord-307860-iqk1yiw4	209	20	)	)	-RRB-
cord-307860-iqk1yiw4	209	21	protein	protein	NN
cord-307860-iqk1yiw4	209	22	[	[	-LRB-
cord-307860-iqk1yiw4	209	23	85	85	CD
cord-307860-iqk1yiw4	209	24	]	]	-RRB-
cord-307860-iqk1yiw4	209	25	.	.	.
cord-307860-iqk1yiw4	210	1	There	there	EX
cord-307860-iqk1yiw4	210	2	are	be	VBP
cord-307860-iqk1yiw4	210	3	nine	nine	CD
cord-307860-iqk1yiw4	210	4	SARS	SARS	NNP
cord-307860-iqk1yiw4	210	5	-	-	HYPH
cord-307860-iqk1yiw4	210	6	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	210	7	X	x	NN
cord-307860-iqk1yiw4	210	8	-	-	NN
cord-307860-iqk1yiw4	210	9	ray	ray	JJ
cord-307860-iqk1yiw4	210	10	structures	structure	NNS
cord-307860-iqk1yiw4	210	11	of	of	IN
cord-307860-iqk1yiw4	210	12	N	n	CD
cord-307860-iqk1yiw4	210	13	protein	protein	NN
cord-307860-iqk1yiw4	210	14	,	,	,
cord-307860-iqk1yiw4	210	15	but	but	CC
cord-307860-iqk1yiw4	210	16	only	only	RB
cord-307860-iqk1yiw4	210	17	one	one	CD
cord-307860-iqk1yiw4	210	18	crystal	crystal	NN
cord-307860-iqk1yiw4	210	19	structure	structure	NN
cord-307860-iqk1yiw4	210	20	is	be	VBZ
cord-307860-iqk1yiw4	210	21	published	publish	VBN
cord-307860-iqk1yiw4	210	22	until	until	IN
cord-307860-iqk1yiw4	210	23	now	now	RB
cord-307860-iqk1yiw4	210	24	(	(	-LRB-
cord-307860-iqk1yiw4	210	25	PDB	PDB	NNP
cord-307860-iqk1yiw4	210	26	ID	ID	NNP
cord-307860-iqk1yiw4	210	27	6M3	6m3	CD
cord-307860-iqk1yiw4	210	28	M	M	NNP
cord-307860-iqk1yiw4	210	29	)	)	-RRB-
cord-307860-iqk1yiw4	210	30	[	[	-LRB-
cord-307860-iqk1yiw4	210	31	33	33	CD
cord-307860-iqk1yiw4	210	32	]	]	-RRB-
cord-307860-iqk1yiw4	210	33	.	.	.
cord-307860-iqk1yiw4	211	1	Similar	similar	JJ
cord-307860-iqk1yiw4	211	2	to	to	IN
cord-307860-iqk1yiw4	211	3	the	the	DT
cord-307860-iqk1yiw4	211	4	N	n	CD
cord-307860-iqk1yiw4	211	5	proteins	protein	NNS
cord-307860-iqk1yiw4	211	6	of	of	IN
cord-307860-iqk1yiw4	211	7	other	other	JJ
cord-307860-iqk1yiw4	211	8	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	211	9	,	,	,
cord-307860-iqk1yiw4	211	10	the	the	DT
cord-307860-iqk1yiw4	211	11	SARS	SARS	NNP
cord-307860-iqk1yiw4	211	12	-	-	HYPH
cord-307860-iqk1yiw4	211	13	CoV-2N	CoV-2N	NNP
cord-307860-iqk1yiw4	211	14	protein	protein	NN
cord-307860-iqk1yiw4	211	15	consists	consist	VBZ
cord-307860-iqk1yiw4	211	16	of	of	IN
cord-307860-iqk1yiw4	211	17	the	the	DT
cord-307860-iqk1yiw4	211	18	N	n	CD
cord-307860-iqk1yiw4	211	19	-	-	HYPH
cord-307860-iqk1yiw4	211	20	terminal	terminal	NN
cord-307860-iqk1yiw4	211	21	RNA	RNA	NNP
cord-307860-iqk1yiw4	211	22	-	-	HYPH
cord-307860-iqk1yiw4	211	23	binding	bind	VBG
cord-307860-iqk1yiw4	211	24	domain	domain	NN
cord-307860-iqk1yiw4	211	25	(	(	-LRB-
cord-307860-iqk1yiw4	211	26	N	N	NNP
cord-307860-iqk1yiw4	211	27	-	-	HYPH
cord-307860-iqk1yiw4	211	28	NTD	NTD	NNP
cord-307860-iqk1yiw4	211	29	)	)	-RRB-
cord-307860-iqk1yiw4	211	30	,	,	,
cord-307860-iqk1yiw4	211	31	the	the	DT
cord-307860-iqk1yiw4	211	32	C	C	NNP
cord-307860-iqk1yiw4	211	33	-	-	HYPH
cord-307860-iqk1yiw4	211	34	terminal	terminal	NN
cord-307860-iqk1yiw4	211	35	dimerization	dimerization	NN
cord-307860-iqk1yiw4	211	36	domain	domain	NN
cord-307860-iqk1yiw4	211	37	(	(	-LRB-
cord-307860-iqk1yiw4	211	38	N	N	NNP
cord-307860-iqk1yiw4	211	39	-	-	HYPH
cord-307860-iqk1yiw4	211	40	CTD	CTD	NNP
cord-307860-iqk1yiw4	211	41	)	)	-RRB-
cord-307860-iqk1yiw4	211	42	,	,	,
cord-307860-iqk1yiw4	211	43	and	and	CC
cord-307860-iqk1yiw4	211	44	a	a	DT
cord-307860-iqk1yiw4	211	45	Ser	Ser	NNP
cord-307860-iqk1yiw4	211	46	/	/	SYM
cord-307860-iqk1yiw4	211	47	Arg	arg	JJ
cord-307860-iqk1yiw4	211	48	rich	rich	JJ
cord-307860-iqk1yiw4	211	49	linker	linker	NN
cord-307860-iqk1yiw4	211	50	[	[	-LRB-
cord-307860-iqk1yiw4	211	51	86	86	CD
cord-307860-iqk1yiw4	211	52	]	]	-RRB-
cord-307860-iqk1yiw4	211	53	.	.	.
cord-307860-iqk1yiw4	212	1	The	the	DT
cord-307860-iqk1yiw4	212	2	ribonucleotide	ribonucleotide	NN
cord-307860-iqk1yiw4	212	3	binding	bind	VBG
cord-307860-iqk1yiw4	212	4	site	site	NN
cord-307860-iqk1yiw4	212	5	of	of	IN
cord-307860-iqk1yiw4	212	6	the	the	DT
cord-307860-iqk1yiw4	212	7	CoV	CoV	NNP
cord-307860-iqk1yiw4	212	8	N	N	NNP
cord-307860-iqk1yiw4	212	9	-	-	HYPH
cord-307860-iqk1yiw4	212	10	NTD	NTD	NNP
cord-307860-iqk1yiw4	212	11	domain	domain	NN
cord-307860-iqk1yiw4	212	12	was	be	VBD
cord-307860-iqk1yiw4	212	13	subject	subject	JJ
cord-307860-iqk1yiw4	212	14	to	to	IN
cord-307860-iqk1yiw4	212	15	structural	structural	JJ
cord-307860-iqk1yiw4	212	16	studies	study	NNS
cord-307860-iqk1yiw4	212	17	to	to	TO
cord-307860-iqk1yiw4	212	18	develop	develop	VB
cord-307860-iqk1yiw4	212	19	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	212	20	that	that	WDT
cord-307860-iqk1yiw4	212	21	specifically	specifically	RB
cord-307860-iqk1yiw4	212	22	reduce	reduce	VBP
cord-307860-iqk1yiw4	212	23	the	the	DT
cord-307860-iqk1yiw4	212	24	RNA	RNA	NNP
cord-307860-iqk1yiw4	212	25	-	-	HYPH
cord-307860-iqk1yiw4	212	26	binding	bind	VBG
cord-307860-iqk1yiw4	212	27	affinity	affinity	NN
cord-307860-iqk1yiw4	212	28	,	,	,
cord-307860-iqk1yiw4	212	29	thus	thus	RB
cord-307860-iqk1yiw4	212	30	altering	alter	VBG
cord-307860-iqk1yiw4	212	31	the	the	DT
cord-307860-iqk1yiw4	212	32	viral	viral	JJ
cord-307860-iqk1yiw4	212	33	replication	replication	NN
cord-307860-iqk1yiw4	212	34	.	.	.
cord-307860-iqk1yiw4	213	1	The	the	DT
cord-307860-iqk1yiw4	213	2	SARS	SARS	NNP
cord-307860-iqk1yiw4	213	3	-	-	HYPH
cord-307860-iqk1yiw4	213	4	CoV-2N	CoV-2N	NNP
cord-307860-iqk1yiw4	213	5	structures	structure	NNS
cord-307860-iqk1yiw4	213	6	available	available	JJ
cord-307860-iqk1yiw4	213	7	are	be	VBP
cord-307860-iqk1yiw4	213	8	not	not	RB
cord-307860-iqk1yiw4	213	9	co	co	JJ
cord-307860-iqk1yiw4	213	10	-	-	VBN
cord-307860-iqk1yiw4	213	11	crystallized	crystallize	VBN
cord-307860-iqk1yiw4	213	12	with	with	IN
cord-307860-iqk1yiw4	213	13	any	any	DT
cord-307860-iqk1yiw4	213	14	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	214	1	,	,	,
cord-307860-iqk1yiw4	214	2	but	but	CC
cord-307860-iqk1yiw4	214	3	the	the	DT
cord-307860-iqk1yiw4	214	4	Kang	Kang	NNP
cord-307860-iqk1yiw4	214	5	et	et	NNP
cord-307860-iqk1yiw4	214	6	al	al	NNP
cord-307860-iqk1yiw4	214	7	.	.	.
cord-307860-iqk1yiw4	215	1	structural	structural	JJ
cord-307860-iqk1yiw4	215	2	study	study	NN
cord-307860-iqk1yiw4	215	3	demonstrated	demonstrate	VBD
cord-307860-iqk1yiw4	215	4	that	that	IN
cord-307860-iqk1yiw4	215	5	the	the	DT
cord-307860-iqk1yiw4	215	6	SARS	SARS	NNP
cord-307860-iqk1yiw4	215	7	-	-	HYPH
cord-307860-iqk1yiw4	215	8	CoV-2N	CoV-2N	NNP
cord-307860-iqk1yiw4	215	9	employs	employ	VBZ
cord-307860-iqk1yiw4	215	10	a	a	DT
cord-307860-iqk1yiw4	215	11	unique	unique	JJ
cord-307860-iqk1yiw4	215	12	pattern	pattern	NN
cord-307860-iqk1yiw4	215	13	for	for	IN
cord-307860-iqk1yiw4	215	14	ribonucleotide	ribonucleotide	NN
cord-307860-iqk1yiw4	215	15	binding	binding	NN
cord-307860-iqk1yiw4	215	16	,	,	,
cord-307860-iqk1yiw4	215	17	the	the	DT
cord-307860-iqk1yiw4	215	18	residues	residue	NNS
cord-307860-iqk1yiw4	215	19	Arg89	Arg89	NNP
cord-307860-iqk1yiw4	215	20	being	be	VBG
cord-307860-iqk1yiw4	215	21	one	one	CD
cord-307860-iqk1yiw4	215	22	reason	reason	NN
cord-307860-iqk1yiw4	215	23	for	for	IN
cord-307860-iqk1yiw4	215	24	the	the	DT
cord-307860-iqk1yiw4	215	25	weak	weak	JJ
cord-307860-iqk1yiw4	215	26	guanosine	guanosine	NN
cord-307860-iqk1yiw4	215	27	base	base	NN
cord-307860-iqk1yiw4	215	28	recognition	recognition	NN
cord-307860-iqk1yiw4	215	29	(	(	-LRB-
cord-307860-iqk1yiw4	215	30	K	k	NN
cord-307860-iqk1yiw4	215	31	D	D	NNP
cord-307860-iqk1yiw4	215	32	for	for	IN
cord-307860-iqk1yiw4	215	33	guanosine	guanosine	NN
cord-307860-iqk1yiw4	215	34	monophosphate	monophosphate	NN
cord-307860-iqk1yiw4	215	35	GMP	GMP	NNP
cord-307860-iqk1yiw4	215	36	is	be	VBZ
cord-307860-iqk1yiw4	215	37	8	8	CD
cord-307860-iqk1yiw4	215	38	mmol	mmol	JJ
cord-307860-iqk1yiw4	215	39	/	/	SYM
cord-307860-iqk1yiw4	215	40	L	l	NN
cord-307860-iqk1yiw4	215	41	)	)	-RRB-
cord-307860-iqk1yiw4	215	42	[	[	-LRB-
cord-307860-iqk1yiw4	215	43	33	33	CD
cord-307860-iqk1yiw4	215	44	]	]	-RRB-
cord-307860-iqk1yiw4	215	45	.	.	.
cord-307860-iqk1yiw4	216	1	The	the	DT
cord-307860-iqk1yiw4	216	2	Kang	Kang	NNP
cord-307860-iqk1yiw4	216	3	et	et	NNP
cord-307860-iqk1yiw4	216	4	al	al	NNP
cord-307860-iqk1yiw4	216	5	.	.	NNP
cord-307860-iqk1yiw4	216	6	claimed	claim	VBD
cord-307860-iqk1yiw4	216	7	that	that	IN
cord-307860-iqk1yiw4	216	8	these	these	DT
cord-307860-iqk1yiw4	216	9	structural	structural	JJ
cord-307860-iqk1yiw4	216	10	characteristics	characteristic	NNS
cord-307860-iqk1yiw4	216	11	could	could	MD
cord-307860-iqk1yiw4	216	12	be	be	VB
cord-307860-iqk1yiw4	216	13	exploited	exploit	VBN
cord-307860-iqk1yiw4	216	14	for	for	IN
cord-307860-iqk1yiw4	216	15	further	further	JJ
cord-307860-iqk1yiw4	216	16	investigation	investigation	NN
cord-307860-iqk1yiw4	216	17	of	of	IN
cord-307860-iqk1yiw4	216	18	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	216	19	compounds	compound	NNS
cord-307860-iqk1yiw4	216	20	,	,	,
cord-307860-iqk1yiw4	216	21	mainly	mainly	RB
cord-307860-iqk1yiw4	216	22	the	the	DT
cord-307860-iqk1yiw4	216	23	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	216	24	PJ34	PJ34	NNP
cord-307860-iqk1yiw4	216	25	of	of	IN
cord-307860-iqk1yiw4	216	26	the	the	DT
cord-307860-iqk1yiw4	216	27	HCoV	HCoV	NNP
cord-307860-iqk1yiw4	216	28	-	-	HYPH
cord-307860-iqk1yiw4	216	29	OC43	OC43	NNP
cord-307860-iqk1yiw4	216	30	N	N	NNP
cord-307860-iqk1yiw4	216	31	-	-	HYPH
cord-307860-iqk1yiw4	216	32	NTD	NTD	NNP
cord-307860-iqk1yiw4	217	1	(	(	-LRB-
cord-307860-iqk1yiw4	217	2	PDB	PDB	NNP
cord-307860-iqk1yiw4	217	3	ID	ID	NNP
cord-307860-iqk1yiw4	217	4	4KXJ	4kxj	CD
cord-307860-iqk1yiw4	217	5	)	)	-RRB-
cord-307860-iqk1yiw4	217	6	which	which	WDT
cord-307860-iqk1yiw4	217	7	reduces	reduce	VBZ
cord-307860-iqk1yiw4	217	8	the	the	DT
cord-307860-iqk1yiw4	217	9	N	N	NNP
cord-307860-iqk1yiw4	217	10	protein	protein	NN
cord-307860-iqk1yiw4	217	11	's	's	POS
cord-307860-iqk1yiw4	217	12	RNA	RNA	NNP
cord-307860-iqk1yiw4	217	13	-	-	HYPH
cord-307860-iqk1yiw4	217	14	binding	bind	VBG
cord-307860-iqk1yiw4	217	15	affinity	affinity	NN
cord-307860-iqk1yiw4	217	16	by	by	IN
cord-307860-iqk1yiw4	217	17	10	10	CD
cord-307860-iqk1yiw4	217	18	%	%	NN
cord-307860-iqk1yiw4	217	19	[	[	-LRB-
cord-307860-iqk1yiw4	217	20	86	86	CD
cord-307860-iqk1yiw4	217	21	]	]	-RRB-
cord-307860-iqk1yiw4	217	22	.	.	.
cord-307860-iqk1yiw4	218	1	Herein	herein	RB
cord-307860-iqk1yiw4	218	2	,	,	,
cord-307860-iqk1yiw4	218	3	a	a	DT
cord-307860-iqk1yiw4	218	4	further	further	JJ
cord-307860-iqk1yiw4	218	5	molecular	molecular	JJ
cord-307860-iqk1yiw4	218	6	docking	docking	NN
cord-307860-iqk1yiw4	218	7	of	of	IN
cord-307860-iqk1yiw4	218	8	the	the	DT
cord-307860-iqk1yiw4	218	9	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	218	10	PJ34	PJ34	NNP
cord-307860-iqk1yiw4	218	11	with	with	IN
cord-307860-iqk1yiw4	218	12	the	the	DT
cord-307860-iqk1yiw4	218	13	SARS	SARS	NNP
cord-307860-iqk1yiw4	218	14	-	-	HYPH
cord-307860-iqk1yiw4	218	15	CoV-2N	CoV-2N	NNP
cord-307860-iqk1yiw4	218	16	-	-	HYPH
cord-307860-iqk1yiw4	218	17	NTD	NTD	NNP
cord-307860-iqk1yiw4	218	18	(	(	-LRB-
cord-307860-iqk1yiw4	218	19	PDB	PDB	NNP
cord-307860-iqk1yiw4	218	20	ID	ID	NNP
cord-307860-iqk1yiw4	218	21	6M3	6m3	CD
cord-307860-iqk1yiw4	218	22	M	M	NNP
cord-307860-iqk1yiw4	218	23	)	)	-RRB-
cord-307860-iqk1yiw4	218	24	was	be	VBD
cord-307860-iqk1yiw4	218	25	made	make	VBN
cord-307860-iqk1yiw4	218	26	.	.	.
cord-307860-iqk1yiw4	219	1	PJ34	PJ34	NNP
cord-307860-iqk1yiw4	219	2	interactions	interaction	NNS
cord-307860-iqk1yiw4	219	3	with	with	IN
cord-307860-iqk1yiw4	219	4	SARS	SARS	NNP
cord-307860-iqk1yiw4	219	5	-	-	HYPH
cord-307860-iqk1yiw4	219	6	CoV-2N	CoV-2N	NNP
cord-307860-iqk1yiw4	219	7	proteins	protein	NNS
cord-307860-iqk1yiw4	219	8	'	'	POS
cord-307860-iqk1yiw4	219	9	N	n	CD
cord-307860-iqk1yiw4	219	10	-	-	HYPH
cord-307860-iqk1yiw4	219	11	terminal	terminal	NN
cord-307860-iqk1yiw4	219	12	domain	domain	NN
cord-307860-iqk1yiw4	219	13	(	(	-LRB-
cord-307860-iqk1yiw4	219	14	NTD	NTD	NNP
cord-307860-iqk1yiw4	219	15	)	)	-RRB-
cord-307860-iqk1yiw4	219	16	were	be	VBD
cord-307860-iqk1yiw4	219	17	compared	compare	VBN
cord-307860-iqk1yiw4	219	18	with	with	IN
cord-307860-iqk1yiw4	219	19	those	those	DT
cord-307860-iqk1yiw4	219	20	of	of	IN
cord-307860-iqk1yiw4	219	21	the	the	DT
cord-307860-iqk1yiw4	219	22	HCoV	HCoV	NNP
cord-307860-iqk1yiw4	219	23	-	-	HYPH
cord-307860-iqk1yiw4	219	24	OC43	OC43	NNP
cord-307860-iqk1yiw4	219	25	co	co	NN
cord-307860-iqk1yiw4	219	26	-	-	VBD
cord-307860-iqk1yiw4	219	27	crystallized	crystallize	VBN
cord-307860-iqk1yiw4	219	28	with	with	IN
cord-307860-iqk1yiw4	219	29	the	the	DT
cord-307860-iqk1yiw4	219	30	PJ34	PJ34	NNP
cord-307860-iqk1yiw4	219	31	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	219	32	(	(	-LRB-
cord-307860-iqk1yiw4	219	33	PDB	PDB	NNP
cord-307860-iqk1yiw4	219	34	ID	ID	NNP
cord-307860-iqk1yiw4	219	35	4KXJ	4kxj	CD
cord-307860-iqk1yiw4	219	36	)	)	-RRB-
cord-307860-iqk1yiw4	219	37	.	.	.
cord-307860-iqk1yiw4	220	1	The	the	DT
cord-307860-iqk1yiw4	220	2	molecular	molecular	JJ
cord-307860-iqk1yiw4	220	3	docking	docking	NN
cord-307860-iqk1yiw4	220	4	of	of	IN
cord-307860-iqk1yiw4	220	5	the	the	DT
cord-307860-iqk1yiw4	220	6	compound	compound	NN
cord-307860-iqk1yiw4	220	7	PJ34	PJ34	NNP
cord-307860-iqk1yiw4	220	8	with	with	IN
cord-307860-iqk1yiw4	220	9	the	the	DT
cord-307860-iqk1yiw4	220	10	PDB	PDB	NNP
cord-307860-iqk1yiw4	220	11	ID	ID	NNP
cord-307860-iqk1yiw4	220	12	6M3	6m3	CD
cord-307860-iqk1yiw4	220	13	M	M	NNP
cord-307860-iqk1yiw4	220	14	shows	show	VBZ
cord-307860-iqk1yiw4	220	15	the	the	DT
cord-307860-iqk1yiw4	220	16	following	follow	VBG
cord-307860-iqk1yiw4	220	17	parameters	parameter	NNS
cord-307860-iqk1yiw4	220	18	:	:	:
cord-307860-iqk1yiw4	220	19	∆G	∆g	NN
cord-307860-iqk1yiw4	220	20	=	=	SYM
cord-307860-iqk1yiw4	220	21	−	−	CD
cord-307860-iqk1yiw4	220	22	5.66	5.66	CD
cord-307860-iqk1yiw4	221	1	and	and	CC
cord-307860-iqk1yiw4	221	2	Ki	Ki	NNP
cord-307860-iqk1yiw4	221	3	=	=	NNP
cord-307860-iqk1yiw4	221	4	71.34	71.34	CD
cord-307860-iqk1yiw4	222	1	μM.	μM.	NNP
cord-307860-iqk1yiw4	223	1	The	the	DT
cord-307860-iqk1yiw4	223	2	interactions	interaction	NNS
cord-307860-iqk1yiw4	223	3	involved	involve	VBD
cord-307860-iqk1yiw4	223	4	the	the	DT
cord-307860-iqk1yiw4	223	5	residues	residue	NNS
cord-307860-iqk1yiw4	223	6	that	that	WDT
cord-307860-iqk1yiw4	223	7	bind	bind	VBP
cord-307860-iqk1yiw4	223	8	the	the	DT
cord-307860-iqk1yiw4	223	9	PJ34	PJ34	NNP
cord-307860-iqk1yiw4	223	10	are	be	VBP
cord-307860-iqk1yiw4	223	11	different	different	JJ
cord-307860-iqk1yiw4	223	12	from	from	IN
cord-307860-iqk1yiw4	223	13	the	the	DT
cord-307860-iqk1yiw4	223	14	residues	residue	NNS
cord-307860-iqk1yiw4	223	15	previously	previously	RB
cord-307860-iqk1yiw4	223	16	described	describe	VBN
cord-307860-iqk1yiw4	223	17	at	at	IN
cord-307860-iqk1yiw4	223	18	its	-PRON-	PRP$
cord-307860-iqk1yiw4	223	19	counterpart	counterpart	NN
cord-307860-iqk1yiw4	223	20	from	from	IN
cord-307860-iqk1yiw4	223	21	HCoV	HCoV	NNP
cord-307860-iqk1yiw4	223	22	-	-	HYPH
cord-307860-iqk1yiw4	223	23	OC43	OC43	NNP
cord-307860-iqk1yiw4	223	24	(	(	-LRB-
cord-307860-iqk1yiw4	223	25	Fig	Fig	NNP
cord-307860-iqk1yiw4	223	26	.	.	.
cord-307860-iqk1yiw4	223	27	4	4	LS
cord-307860-iqk1yiw4	223	28	)	)	-RRB-
cord-307860-iqk1yiw4	223	29	[	[	-LRB-
cord-307860-iqk1yiw4	223	30	86	86	CD
cord-307860-iqk1yiw4	223	31	]	]	-RRB-
cord-307860-iqk1yiw4	223	32	.	.	.
cord-307860-iqk1yiw4	224	1	The	the	DT
cord-307860-iqk1yiw4	224	2	molecular	molecular	JJ
cord-307860-iqk1yiw4	224	3	docking	docking	NN
cord-307860-iqk1yiw4	224	4	offers	offer	VBZ
cord-307860-iqk1yiw4	224	5	only	only	RB
cord-307860-iqk1yiw4	224	6	a	a	DT
cord-307860-iqk1yiw4	224	7	quick	quick	JJ
cord-307860-iqk1yiw4	224	8	view	view	NN
cord-307860-iqk1yiw4	224	9	about	about	IN
cord-307860-iqk1yiw4	224	10	ligand	ligand	NN
cord-307860-iqk1yiw4	224	11	-	-	HYPH
cord-307860-iqk1yiw4	224	12	protein	protein	NN
cord-307860-iqk1yiw4	224	13	interaction	interaction	NN
cord-307860-iqk1yiw4	224	14	,	,	,
cord-307860-iqk1yiw4	224	15	deeper	deep	JJR
cord-307860-iqk1yiw4	224	16	theoretical	theoretical	JJ
cord-307860-iqk1yiw4	224	17	analysis	analysis	NN
cord-307860-iqk1yiw4	224	18	,	,	,
cord-307860-iqk1yiw4	224	19	and	and	CC
cord-307860-iqk1yiw4	224	20	experimental	experimental	JJ
cord-307860-iqk1yiw4	224	21	validation	validation	NN
cord-307860-iqk1yiw4	224	22	should	should	MD
cord-307860-iqk1yiw4	224	23	be	be	VB
cord-307860-iqk1yiw4	224	24	made	make	VBN
cord-307860-iqk1yiw4	224	25	.	.	.
cord-307860-iqk1yiw4	225	1	Sequence	sequence	NN
cord-307860-iqk1yiw4	225	2	comparison	comparison	NN
cord-307860-iqk1yiw4	225	3	of	of	IN
cord-307860-iqk1yiw4	225	4	the	the	DT
cord-307860-iqk1yiw4	225	5	N	N	NNP
cord-307860-iqk1yiw4	225	6	proteins	protein	NNS
cord-307860-iqk1yiw4	225	7	'	'	POS
cord-307860-iqk1yiw4	225	8	N	n	CD
cord-307860-iqk1yiw4	225	9	-	-	HYPH
cord-307860-iqk1yiw4	225	10	terminal	terminal	NN
cord-307860-iqk1yiw4	225	11	domain	domain	NN
cord-307860-iqk1yiw4	225	12	(	(	-LRB-
cord-307860-iqk1yiw4	225	13	NTD	NTD	NNP
cord-307860-iqk1yiw4	225	14	)	)	-RRB-
cord-307860-iqk1yiw4	225	15	of	of	IN
cord-307860-iqk1yiw4	225	16	the	the	DT
cord-307860-iqk1yiw4	225	17	HCoV	HCoV	NNP
cord-307860-iqk1yiw4	225	18	-	-	HYPH
cord-307860-iqk1yiw4	225	19	OC43	OC43	NNP
cord-307860-iqk1yiw4	225	20	and	and	CC
cord-307860-iqk1yiw4	225	21	SARS	SARS	NNP
cord-307860-iqk1yiw4	225	22	-	-	HYPH
cord-307860-iqk1yiw4	225	23	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	225	24	reveals	reveal	VBZ
cord-307860-iqk1yiw4	225	25	some	some	DT
cord-307860-iqk1yiw4	225	26	particularities	particularity	NNS
cord-307860-iqk1yiw4	225	27	that	that	WDT
cord-307860-iqk1yiw4	225	28	are	be	VBP
cord-307860-iqk1yiw4	225	29	worth	worth	JJ
cord-307860-iqk1yiw4	225	30	further	further	JJ
cord-307860-iqk1yiw4	225	31	investigation	investigation	NN
cord-307860-iqk1yiw4	225	32	.	.	.
cord-307860-iqk1yiw4	226	1	The	the	DT
cord-307860-iqk1yiw4	226	2	sequence	sequence	NN
cord-307860-iqk1yiw4	226	3	positions	position	VBZ
cord-307860-iqk1yiw4	226	4	48	48	CD
cord-307860-iqk1yiw4	226	5	to	to	TO
cord-307860-iqk1yiw4	226	6	51	51	CD
cord-307860-iqk1yiw4	226	7	(	(	-LRB-
cord-307860-iqk1yiw4	226	8	48-NNTA-51	48-nnta-51	CD
cord-307860-iqk1yiw4	226	9	)	)	-RRB-
cord-307860-iqk1yiw4	226	10	allows	allow	VBZ
cord-307860-iqk1yiw4	226	11	easier	easy	JJR
cord-307860-iqk1yiw4	226	12	access	access	NN
cord-307860-iqk1yiw4	226	13	of	of	IN
cord-307860-iqk1yiw4	226	14	the	the	DT
cord-307860-iqk1yiw4	226	15	nucleotides	nucleotide	NNS
cord-307860-iqk1yiw4	226	16	.	.	.
cord-307860-iqk1yiw4	227	1	The	the	DT
cord-307860-iqk1yiw4	227	2	threonine	threonine	NN
cord-307860-iqk1yiw4	227	3	T55	T55	NNP
cord-307860-iqk1yiw4	227	4	and	and	CC
cord-307860-iqk1yiw4	227	5	alanine	alanine	NN
cord-307860-iqk1yiw4	227	6	A56	A56	NNP
cord-307860-iqk1yiw4	227	7	increase	increase	VB
cord-307860-iqk1yiw4	227	8	the	the	DT
cord-307860-iqk1yiw4	227	9	steric	steric	JJ
cord-307860-iqk1yiw4	227	10	clash	clash	NN
cord-307860-iqk1yiw4	227	11	with	with	IN
cord-307860-iqk1yiw4	227	12	ribonucleotide	ribonucleotide	NN
cord-307860-iqk1yiw4	227	13	phosphate	phosphate	NN
cord-307860-iqk1yiw4	227	14	moiety	moiety	NN
cord-307860-iqk1yiw4	227	15	.	.	.
cord-307860-iqk1yiw4	228	1	The	the	DT
cord-307860-iqk1yiw4	228	2	arginine	arginine	NN
cord-307860-iqk1yiw4	228	3	R89	R89	NNP
cord-307860-iqk1yiw4	228	4	increases	increase	VBZ
cord-307860-iqk1yiw4	228	5	the	the	DT
cord-307860-iqk1yiw4	228	6	polar	polar	JJ
cord-307860-iqk1yiw4	228	7	features	feature	NNS
cord-307860-iqk1yiw4	228	8	in	in	IN
cord-307860-iqk1yiw4	228	9	the	the	DT
cord-307860-iqk1yiw4	228	10	nitrogenous	nitrogenous	JJ
cord-307860-iqk1yiw4	228	11	base	base	NN
cord-307860-iqk1yiw4	228	12	binding	binding	NN
cord-307860-iqk1yiw4	228	13	site	site	NN
cord-307860-iqk1yiw4	228	14	.	.	.
cord-307860-iqk1yiw4	229	1	(	(	-LRB-
cord-307860-iqk1yiw4	229	2	Fig	Fig	NNP
cord-307860-iqk1yiw4	229	3	.	.	.
cord-307860-iqk1yiw4	230	1	5	5	LS
cord-307860-iqk1yiw4	230	2	)	)	-RRB-
cord-307860-iqk1yiw4	230	3	[	[	-LRB-
cord-307860-iqk1yiw4	230	4	33	33	CD
cord-307860-iqk1yiw4	230	5	]	]	-RRB-
cord-307860-iqk1yiw4	230	6	.	.	.
cord-307860-iqk1yiw4	231	1	There	there	EX
cord-307860-iqk1yiw4	231	2	are	be	VBP
cord-307860-iqk1yiw4	231	3	many	many	JJ
cord-307860-iqk1yiw4	231	4	works	work	NNS
cord-307860-iqk1yiw4	231	5	about	about	IN
cord-307860-iqk1yiw4	231	6	the	the	DT
cord-307860-iqk1yiw4	231	7	cell	cell	NN
cord-307860-iqk1yiw4	231	8	entry	entry	NN
cord-307860-iqk1yiw4	231	9	of	of	IN
cord-307860-iqk1yiw4	231	10	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	231	11	because	because	IN
cord-307860-iqk1yiw4	231	12	,	,	,
cord-307860-iqk1yiw4	231	13	on	on	IN
cord-307860-iqk1yiw4	231	14	the	the	DT
cord-307860-iqk1yiw4	231	15	one	one	CD
cord-307860-iqk1yiw4	231	16	hand	hand	NN
cord-307860-iqk1yiw4	231	17	,	,	,
cord-307860-iqk1yiw4	231	18	this	this	DT
cord-307860-iqk1yiw4	231	19	step	step	NN
cord-307860-iqk1yiw4	231	20	is	be	VBZ
cord-307860-iqk1yiw4	231	21	crucial	crucial	JJ
cord-307860-iqk1yiw4	231	22	for	for	IN
cord-307860-iqk1yiw4	231	23	tissue	tissue	NN
cord-307860-iqk1yiw4	231	24	and	and	CC
cord-307860-iqk1yiw4	231	25	cell	cell	NN
cord-307860-iqk1yiw4	231	26	tropism	tropism	NN
cord-307860-iqk1yiw4	231	27	,	,	,
cord-307860-iqk1yiw4	231	28	and	and	CC
cord-307860-iqk1yiw4	231	29	on	on	IN
cord-307860-iqk1yiw4	231	30	the	the	DT
cord-307860-iqk1yiw4	231	31	other	other	JJ
cord-307860-iqk1yiw4	231	32	hand	hand	NN
cord-307860-iqk1yiw4	231	33	,	,	,
cord-307860-iqk1yiw4	231	34	it	-PRON-	PRP
cord-307860-iqk1yiw4	231	35	gains	gain	VBZ
cord-307860-iqk1yiw4	231	36	insight	insight	NN
cord-307860-iqk1yiw4	231	37	into	into	IN
cord-307860-iqk1yiw4	231	38	the	the	DT
cord-307860-iqk1yiw4	231	39	ability	ability	NN
cord-307860-iqk1yiw4	231	40	for	for	IN
cord-307860-iqk1yiw4	231	41	interspecies	interspecie	NNS
cord-307860-iqk1yiw4	231	42	transmission	transmission	NN
cord-307860-iqk1yiw4	231	43	.	.	.
cord-307860-iqk1yiw4	232	1	The	the	DT
cord-307860-iqk1yiw4	232	2	viral	viral	JJ
cord-307860-iqk1yiw4	232	3	entry	entry	NN
cord-307860-iqk1yiw4	232	4	is	be	VBZ
cord-307860-iqk1yiw4	232	5	crucial	crucial	JJ
cord-307860-iqk1yiw4	232	6	for	for	IN
cord-307860-iqk1yiw4	232	7	viral	viral	JJ
cord-307860-iqk1yiw4	232	8	replication	replication	NN
cord-307860-iqk1yiw4	232	9	.	.	.
cord-307860-iqk1yiw4	233	1	Therefore	therefore	RB
cord-307860-iqk1yiw4	233	2	its	-PRON-	PRP$
cord-307860-iqk1yiw4	233	3	deep	deep	JJ
cord-307860-iqk1yiw4	233	4	understanding	understanding	NN
cord-307860-iqk1yiw4	233	5	explains	explain	VBZ
cord-307860-iqk1yiw4	233	6	the	the	DT
cord-307860-iqk1yiw4	233	7	SARS	SARS	NNP
cord-307860-iqk1yiw4	233	8	-	-	HYPH
cord-307860-iqk1yiw4	233	9	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	233	10	pathogenesis	pathogenesis	NN
cord-307860-iqk1yiw4	233	11	and	and	CC
cord-307860-iqk1yiw4	233	12	speeds	speed	VBZ
cord-307860-iqk1yiw4	233	13	up	up	RP
cord-307860-iqk1yiw4	233	14	the	the	DT
cord-307860-iqk1yiw4	233	15	finding	finding	NN
cord-307860-iqk1yiw4	233	16	of	of	IN
cord-307860-iqk1yiw4	233	17	a	a	DT
cord-307860-iqk1yiw4	233	18	specific	specific	JJ
cord-307860-iqk1yiw4	233	19	treatment	treatment	NN
cord-307860-iqk1yiw4	233	20	.	.	.
cord-307860-iqk1yiw4	234	1	The	the	DT
cord-307860-iqk1yiw4	234	2	cell	cell	NN
cord-307860-iqk1yiw4	234	3	entry	entry	NN
cord-307860-iqk1yiw4	234	4	is	be	VBZ
cord-307860-iqk1yiw4	234	5	a	a	DT
cord-307860-iqk1yiw4	234	6	different	different	JJ
cord-307860-iqk1yiw4	234	7	multi	multi	JJ
cord-307860-iqk1yiw4	234	8	-	-	JJ
cord-307860-iqk1yiw4	234	9	step	step	JJ
cord-307860-iqk1yiw4	234	10	process	process	NN
cord-307860-iqk1yiw4	234	11	for	for	IN
cord-307860-iqk1yiw4	234	12	each	each	DT
cord-307860-iqk1yiw4	234	13	CoV.	CoV.	NNP
cord-307860-iqk1yiw4	235	1	The	the	DT
cord-307860-iqk1yiw4	235	2	first	first	JJ
cord-307860-iqk1yiw4	235	3	step	step	NN
cord-307860-iqk1yiw4	235	4	of	of	IN
cord-307860-iqk1yiw4	235	5	any	any	DT
cord-307860-iqk1yiw4	235	6	viral	viral	JJ
cord-307860-iqk1yiw4	235	7	infection	infection	NN
cord-307860-iqk1yiw4	235	8	is	be	VBZ
cord-307860-iqk1yiw4	235	9	the	the	DT
cord-307860-iqk1yiw4	235	10	presence	presence	NN
cord-307860-iqk1yiw4	235	11	of	of	IN
cord-307860-iqk1yiw4	235	12	at	at	RB
cord-307860-iqk1yiw4	235	13	least	least	RBS
cord-307860-iqk1yiw4	235	14	one	one	CD
cord-307860-iqk1yiw4	235	15	suitable	suitable	JJ
cord-307860-iqk1yiw4	235	16	host	host	NN
cord-307860-iqk1yiw4	235	17	receptor	receptor	NN
cord-307860-iqk1yiw4	235	18	.	.	.
cord-307860-iqk1yiw4	236	1	The	the	DT
cord-307860-iqk1yiw4	236	2	spike	spike	NN
cord-307860-iqk1yiw4	236	3	(	(	-LRB-
cord-307860-iqk1yiw4	236	4	S	S	NNP
cord-307860-iqk1yiw4	236	5	)	)	-RRB-
cord-307860-iqk1yiw4	236	6	,	,	,
cord-307860-iqk1yiw4	236	7	a	a	DT
cord-307860-iqk1yiw4	236	8	heavily	heavily	RB
cord-307860-iqk1yiw4	236	9	glycosylated	glycosylated	JJ
cord-307860-iqk1yiw4	236	10	type	type	NN
cord-307860-iqk1yiw4	236	11	I	-PRON-	PRP
cord-307860-iqk1yiw4	236	12	transmembrane	transmembrane	NN
cord-307860-iqk1yiw4	236	13	glycoprotein	glycoprotein	NN
cord-307860-iqk1yiw4	236	14	,	,	,
cord-307860-iqk1yiw4	236	15	is	be	VBZ
cord-307860-iqk1yiw4	236	16	the	the	DT
cord-307860-iqk1yiw4	236	17	same	same	JJ
cord-307860-iqk1yiw4	236	18	to	to	IN
cord-307860-iqk1yiw4	236	19	all	all	DT
cord-307860-iqk1yiw4	236	20	HCoVs	hcovs	CD
cord-307860-iqk1yiw4	236	21	,	,	,
cord-307860-iqk1yiw4	236	22	but	but	CC
cord-307860-iqk1yiw4	236	23	the	the	DT
cord-307860-iqk1yiw4	236	24	host	host	NN
cord-307860-iqk1yiw4	236	25	receptor	receptor	NN
cord-307860-iqk1yiw4	236	26	is	be	VBZ
cord-307860-iqk1yiw4	236	27	different	different	JJ
cord-307860-iqk1yiw4	236	28	[	[	-LRB-
cord-307860-iqk1yiw4	236	29	87	87	CD
cord-307860-iqk1yiw4	236	30	]	]	-RRB-
cord-307860-iqk1yiw4	236	31	.	.	.
cord-307860-iqk1yiw4	237	1	Similar	similar	JJ
cord-307860-iqk1yiw4	237	2	to	to	IN
cord-307860-iqk1yiw4	237	3	the	the	DT
cord-307860-iqk1yiw4	237	4	SARS	SARS	NNP
cord-307860-iqk1yiw4	237	5	-	-	HYPH
cord-307860-iqk1yiw4	237	6	CoV	CoV	NNP
cord-307860-iqk1yiw4	237	7	and	and	CC
cord-307860-iqk1yiw4	237	8	human	human	JJ
cord-307860-iqk1yiw4	237	9	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	238	1	NL63	NL63	NNP
cord-307860-iqk1yiw4	239	1	(	(	-LRB-
cord-307860-iqk1yiw4	239	2	HCoV	HCoV	NNP
cord-307860-iqk1yiw4	239	3	-	-	HYPH
cord-307860-iqk1yiw4	239	4	NL63	NL63	NNP
cord-307860-iqk1yiw4	239	5	)	)	-RRB-
cord-307860-iqk1yiw4	239	6	,	,	,
cord-307860-iqk1yiw4	239	7	the	the	DT
cord-307860-iqk1yiw4	239	8	SARS	SARS	NNP
cord-307860-iqk1yiw4	239	9	-	-	HYPH
cord-307860-iqk1yiw4	239	10	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	239	11	attaches	attach	VBZ
cord-307860-iqk1yiw4	239	12	to	to	TO
cord-307860-iqk1yiw4	239	13	host	host	VB
cord-307860-iqk1yiw4	239	14	receptor	receptor	NN
cord-307860-iqk1yiw4	239	15	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	239	16	by	by	IN
cord-307860-iqk1yiw4	239	17	S	S	NNP
cord-307860-iqk1yiw4	239	18	glycoprotein	glycoprotein	NN
cord-307860-iqk1yiw4	239	19	[	[	-LRB-
cord-307860-iqk1yiw4	239	20	3	3	CD
cord-307860-iqk1yiw4	239	21	,	,	,
cord-307860-iqk1yiw4	239	22	88	88	CD
cord-307860-iqk1yiw4	239	23	,	,	,
cord-307860-iqk1yiw4	239	24	89	89	CD
cord-307860-iqk1yiw4	239	25	]	]	-RRB-
cord-307860-iqk1yiw4	239	26	.	.	.
cord-307860-iqk1yiw4	240	1	In	in	IN
cord-307860-iqk1yiw4	240	2	contrast	contrast	NN
cord-307860-iqk1yiw4	240	3	,	,	,
cord-307860-iqk1yiw4	240	4	the	the	DT
cord-307860-iqk1yiw4	240	5	MERS	MERS	NNP
cord-307860-iqk1yiw4	240	6	-	-	HYPH
cord-307860-iqk1yiw4	240	7	CoV	CoV	NNP
cord-307860-iqk1yiw4	240	8	uses	use	VBZ
cord-307860-iqk1yiw4	240	9	cellular	cellular	JJ
cord-307860-iqk1yiw4	240	10	receptor	receptor	NN
cord-307860-iqk1yiw4	240	11	dipeptidyl	dipeptidyl	NN
cord-307860-iqk1yiw4	240	12	peptidase-4	peptidase-4	NNP
cord-307860-iqk1yiw4	240	13	(	(	-LRB-
cord-307860-iqk1yiw4	240	14	DPP4	DPP4	NNP
cord-307860-iqk1yiw4	240	15	)	)	-RRB-
cord-307860-iqk1yiw4	240	16	,	,	,
cord-307860-iqk1yiw4	240	17	known	know	VBN
cord-307860-iqk1yiw4	240	18	as	as	IN
cord-307860-iqk1yiw4	240	19	CD2	CD2	NNP
cord-307860-iqk1yiw4	240	20	receptor	receptor	NNP
cord-307860-iqk1yiw4	240	21	[	[	-LRB-
cord-307860-iqk1yiw4	240	22	90	90	CD
cord-307860-iqk1yiw4	240	23	]	]	-RRB-
cord-307860-iqk1yiw4	240	24	[	[	-LRB-
cord-307860-iqk1yiw4	240	25	91	91	CD
cord-307860-iqk1yiw4	240	26	]	]	-RRB-
cord-307860-iqk1yiw4	240	27	[	[	-LRB-
cord-307860-iqk1yiw4	240	28	92	92	CD
cord-307860-iqk1yiw4	240	29	]	]	-RRB-
cord-307860-iqk1yiw4	240	30	.	.	.
cord-307860-iqk1yiw4	241	1	The	the	DT
cord-307860-iqk1yiw4	241	2	S	S	NNP
cord-307860-iqk1yiw4	241	3	glycoprotein	glycoprotein	NN
cord-307860-iqk1yiw4	241	4	(	(	-LRB-
cord-307860-iqk1yiw4	241	5	UniProtKB	uniprotkb	CD
cord-307860-iqk1yiw4	241	6	P59594	P59594	NNP
cord-307860-iqk1yiw4	241	7	)	)	-RRB-
cord-307860-iqk1yiw4	241	8	is	be	VBZ
cord-307860-iqk1yiw4	241	9	a	a	DT
cord-307860-iqk1yiw4	241	10	homotrimer	homotrimer	NN
cord-307860-iqk1yiw4	241	11	and	and	CC
cord-307860-iqk1yiw4	241	12	each	each	DT
cord-307860-iqk1yiw4	241	13	monomer	monomer	NN
cord-307860-iqk1yiw4	241	14	contains	contain	VBZ
cord-307860-iqk1yiw4	241	15	two	two	CD
cord-307860-iqk1yiw4	241	16	distinct	distinct	JJ
cord-307860-iqk1yiw4	241	17	functional	functional	JJ
cord-307860-iqk1yiw4	241	18	subunits	subunit	NNS
cord-307860-iqk1yiw4	241	19	-	-	:
cord-307860-iqk1yiw4	241	20	S1	s1	NN
cord-307860-iqk1yiw4	241	21	and	and	CC
cord-307860-iqk1yiw4	241	22	S2-that	s2-that	NN
cord-307860-iqk1yiw4	241	23	are	be	VBP
cord-307860-iqk1yiw4	241	24	subject	subject	JJ
cord-307860-iqk1yiw4	241	25	to	to	IN
cord-307860-iqk1yiw4	241	26	proteolytic	proteolytic	JJ
cord-307860-iqk1yiw4	241	27	cleavage	cleavage	NN
cord-307860-iqk1yiw4	241	28	by	by	IN
cord-307860-iqk1yiw4	241	29	cellular	cellular	JJ
cord-307860-iqk1yiw4	241	30	proteases	protease	NNS
cord-307860-iqk1yiw4	241	31	.	.	.
cord-307860-iqk1yiw4	242	1	The	the	DT
cord-307860-iqk1yiw4	242	2	host	host	NN
cord-307860-iqk1yiw4	242	3	factors	factor	NNS
cord-307860-iqk1yiw4	242	4	involved	involve	VBN
cord-307860-iqk1yiw4	242	5	in	in	IN
cord-307860-iqk1yiw4	242	6	priming	prime	VBG
cord-307860-iqk1yiw4	242	7	the	the	DT
cord-307860-iqk1yiw4	242	8	S	S	NNP
cord-307860-iqk1yiw4	242	9	glycoprotein	glycoprotein	NN
cord-307860-iqk1yiw4	242	10	are	be	VBP
cord-307860-iqk1yiw4	242	11	the	the	DT
cord-307860-iqk1yiw4	242	12	type	type	NN
cord-307860-iqk1yiw4	242	13	II	II	NNP
cord-307860-iqk1yiw4	242	14	transmembrane	transmembrane	NN
cord-307860-iqk1yiw4	242	15	serine	serine	NN
cord-307860-iqk1yiw4	242	16	protease	protease	NN
cord-307860-iqk1yiw4	242	17	2	2	CD
cord-307860-iqk1yiw4	242	18	(	(	-LRB-
cord-307860-iqk1yiw4	242	19	TMPRSS2	TMPRSS2	NNP
cord-307860-iqk1yiw4	242	20	)	)	-RRB-
cord-307860-iqk1yiw4	242	21	and	and	CC
cord-307860-iqk1yiw4	242	22	furin	furin	NN
cord-307860-iqk1yiw4	242	23	[	[	-LRB-
cord-307860-iqk1yiw4	242	24	30	30	CD
cord-307860-iqk1yiw4	242	25	,	,	,
cord-307860-iqk1yiw4	242	26	[	[	-LRB-
cord-307860-iqk1yiw4	242	27	93	93	CD
cord-307860-iqk1yiw4	242	28	]	]	-RRB-
cord-307860-iqk1yiw4	242	29	[	[	-LRB-
cord-307860-iqk1yiw4	242	30	94	94	CD
cord-307860-iqk1yiw4	242	31	]	]	-RRB-
cord-307860-iqk1yiw4	242	32	[	[	-LRB-
cord-307860-iqk1yiw4	242	33	95	95	CD
cord-307860-iqk1yiw4	242	34	]	]	-RRB-
cord-307860-iqk1yiw4	242	35	.	.	.
cord-307860-iqk1yiw4	243	1	The	the	DT
cord-307860-iqk1yiw4	243	2	TMPRSS2	TMPRSS2	NNP
cord-307860-iqk1yiw4	243	3	is	be	VBZ
cord-307860-iqk1yiw4	243	4	predominantly	predominantly	RB
cord-307860-iqk1yiw4	243	5	expressed	express	VBN
cord-307860-iqk1yiw4	243	6	in	in	IN
cord-307860-iqk1yiw4	243	7	the	the	DT
cord-307860-iqk1yiw4	243	8	prostate	prostate	NN
cord-307860-iqk1yiw4	243	9	.	.	.
cord-307860-iqk1yiw4	244	1	Thus	thus	RB
cord-307860-iqk1yiw4	244	2	,	,	,
cord-307860-iqk1yiw4	244	3	the	the	DT
cord-307860-iqk1yiw4	244	4	demonstration	demonstration	NN
cord-307860-iqk1yiw4	244	5	that	that	WDT
cord-307860-iqk1yiw4	244	6	its	-PRON-	PRP$
cord-307860-iqk1yiw4	244	7	expression	expression	NN
cord-307860-iqk1yiw4	244	8	is	be	VBZ
cord-307860-iqk1yiw4	244	9	androgen	androgen	NN
cord-307860-iqk1yiw4	244	10	-	-	HYPH
cord-307860-iqk1yiw4	244	11	dependent	dependent	JJ
cord-307860-iqk1yiw4	244	12	could	could	MD
cord-307860-iqk1yiw4	244	13	explain	explain	VB
cord-307860-iqk1yiw4	244	14	the	the	DT
cord-307860-iqk1yiw4	244	15	gender	gender	NN
cord-307860-iqk1yiw4	244	16	differences	difference	NNS
cord-307860-iqk1yiw4	244	17	in	in	IN
cord-307860-iqk1yiw4	244	18	the	the	DT
cord-307860-iqk1yiw4	244	19	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	244	20	outcome	outcome	NN
cord-307860-iqk1yiw4	244	21	.	.	.
cord-307860-iqk1yiw4	245	1	Also	also	RB
cord-307860-iqk1yiw4	245	2	,	,	,
cord-307860-iqk1yiw4	245	3	the	the	DT
cord-307860-iqk1yiw4	245	4	TMPRSS2	TMPRSS2	NNP
cord-307860-iqk1yiw4	245	5	has	have	VBZ
cord-307860-iqk1yiw4	245	6	a	a	DT
cord-307860-iqk1yiw4	245	7	crucial	crucial	JJ
cord-307860-iqk1yiw4	245	8	role	role	NN
cord-307860-iqk1yiw4	245	9	in	in	IN
cord-307860-iqk1yiw4	245	10	other	other	JJ
cord-307860-iqk1yiw4	245	11	viral	viral	JJ
cord-307860-iqk1yiw4	245	12	infections	infection	NNS
cord-307860-iqk1yiw4	245	13	explaining	explain	VBG
cord-307860-iqk1yiw4	245	14	the	the	DT
cord-307860-iqk1yiw4	245	15	pneumotropism	pneumotropism	NN
cord-307860-iqk1yiw4	245	16	of	of	IN
cord-307860-iqk1yiw4	245	17	H7N9	H7N9	NNP
cord-307860-iqk1yiw4	245	18	and	and	CC
cord-307860-iqk1yiw4	245	19	some	some	DT
cord-307860-iqk1yiw4	245	20	subtypes	subtype	NNS
cord-307860-iqk1yiw4	245	21	of	of	IN
cord-307860-iqk1yiw4	245	22	influenza	influenza	NN
cord-307860-iqk1yiw4	245	23	viruses	virus	NNS
cord-307860-iqk1yiw4	245	24	[	[	-LRB-
cord-307860-iqk1yiw4	245	25	96	96	CD
cord-307860-iqk1yiw4	245	26	]	]	-RRB-
cord-307860-iqk1yiw4	245	27	.	.	.
cord-307860-iqk1yiw4	246	1	The	the	DT
cord-307860-iqk1yiw4	246	2	furin	furin	NN
cord-307860-iqk1yiw4	246	3	(	(	-LRB-
cord-307860-iqk1yiw4	246	4	E.C.	E.C.	NNP
cord-307860-iqk1yiw4	246	5	3.4.21.75	3.4.21.75	CD
cord-307860-iqk1yiw4	246	6	)	)	-RRB-
cord-307860-iqk1yiw4	246	7	(	(	-LRB-
cord-307860-iqk1yiw4	246	8	PDB	PDB	NNP
cord-307860-iqk1yiw4	246	9	ID(s	ID(s	NNP
cord-307860-iqk1yiw4	246	10	)	)	-RRB-
cord-307860-iqk1yiw4	246	11	4OMC	4omc	CD
cord-307860-iqk1yiw4	246	12	,	,	,
cord-307860-iqk1yiw4	246	13	4OMD	4omd	CD
cord-307860-iqk1yiw4	246	14	,	,	,
cord-307860-iqk1yiw4	246	15	etc	etc	FW
cord-307860-iqk1yiw4	246	16	.	.	.
cord-307860-iqk1yiw4	246	17	)	)	-RRB-
cord-307860-iqk1yiw4	247	1	(	(	-LRB-
cord-307860-iqk1yiw4	247	2	UniprotKB	uniprotkb	JJ
cord-307860-iqk1yiw4	247	3	P09958	P09958	NNP
cord-307860-iqk1yiw4	247	4	)	)	-RRB-
cord-307860-iqk1yiw4	247	5	is	be	VBZ
cord-307860-iqk1yiw4	247	6	a	a	DT
cord-307860-iqk1yiw4	247	7	ubiquitous	ubiquitous	JJ
cord-307860-iqk1yiw4	247	8	endoprotease	endoprotease	NN
cord-307860-iqk1yiw4	247	9	that	that	WDT
cord-307860-iqk1yiw4	247	10	belongs	belong	VBZ
cord-307860-iqk1yiw4	247	11	to	to	IN
cord-307860-iqk1yiw4	247	12	the	the	DT
cord-307860-iqk1yiw4	247	13	family	family	NN
cord-307860-iqk1yiw4	247	14	of	of	IN
cord-307860-iqk1yiw4	247	15	proprotein	proprotein	NNP
cord-307860-iqk1yiw4	247	16	convertases	convertases	NNP
cord-307860-iqk1yiw4	247	17	.	.	.
cord-307860-iqk1yiw4	248	1	The	the	DT
cord-307860-iqk1yiw4	248	2	furin	furin	NN
cord-307860-iqk1yiw4	248	3	mediates	mediate	VBZ
cord-307860-iqk1yiw4	248	4	the	the	DT
cord-307860-iqk1yiw4	248	5	priming	priming	NN
cord-307860-iqk1yiw4	248	6	of	of	IN
cord-307860-iqk1yiw4	248	7	various	various	JJ
cord-307860-iqk1yiw4	248	8	proteins	protein	NNS
cord-307860-iqk1yiw4	248	9	-	-	:
cord-307860-iqk1yiw4	248	10	some	some	DT
cord-307860-iqk1yiw4	248	11	bacterial	bacterial	JJ
cord-307860-iqk1yiw4	248	12	toxins	toxin	NNS
cord-307860-iqk1yiw4	248	13	,	,	,
cord-307860-iqk1yiw4	248	14	H7N1and	H7N1and	NNP
cord-307860-iqk1yiw4	248	15	H5N1	H5N1	NNP
cord-307860-iqk1yiw4	248	16	influenza	influenza	NN
cord-307860-iqk1yiw4	248	17	virus	virus	NN
cord-307860-iqk1yiw4	248	18	haemagglutinin	haemagglutinin	NNP
cord-307860-iqk1yiw4	248	19	[	[	-LRB-
cord-307860-iqk1yiw4	248	20	97	97	CD
cord-307860-iqk1yiw4	248	21	,	,	,
cord-307860-iqk1yiw4	248	22	98	98	CD
cord-307860-iqk1yiw4	248	23	]	]	-RRB-
cord-307860-iqk1yiw4	248	24	.	.	.
cord-307860-iqk1yiw4	249	1	The	the	DT
cord-307860-iqk1yiw4	249	2	proprotein	proprotein	NNP
cord-307860-iqk1yiw4	249	3	convertases	convertases	NNP
cord-307860-iqk1yiw4	249	4	(	(	-LRB-
cord-307860-iqk1yiw4	249	5	PPC	PPC	NNP
cord-307860-iqk1yiw4	249	6	)	)	-RRB-
cord-307860-iqk1yiw4	249	7	cleave	cleave	VB
cord-307860-iqk1yiw4	249	8	at	at	IN
cord-307860-iqk1yiw4	249	9	single	single	JJ
cord-307860-iqk1yiw4	249	10	or	or	CC
cord-307860-iqk1yiw4	249	11	paired	pair	VBN
cord-307860-iqk1yiw4	249	12	basic	basic	JJ
cord-307860-iqk1yiw4	249	13	residues	residue	NNS
cord-307860-iqk1yiw4	249	14	within	within	IN
cord-307860-iqk1yiw4	249	15	the	the	DT
cord-307860-iqk1yiw4	249	16	motif	motif	NN
cord-307860-iqk1yiw4	249	17	R	r	NN
cord-307860-iqk1yiw4	249	18	/	/	SYM
cord-307860-iqk1yiw4	249	19	K-(X	k-(x	NN
cord-307860-iqk1yiw4	249	20	)	)	-RRB-
cord-307860-iqk1yiw4	249	21	0,2,4,6	0,2,4,6	.
cord-307860-iqk1yiw4	250	1	-R	-R	.
cord-307860-iqk1yiw4	251	1	/K	/K	NNP
cord-307860-iqk1yiw4	251	2	(	(	-LRB-
cord-307860-iqk1yiw4	251	3	where	where	WRB
cord-307860-iqk1yiw4	251	4	X	x	NN
cord-307860-iqk1yiw4	251	5	means	mean	VBZ
cord-307860-iqk1yiw4	251	6	any	any	DT
cord-307860-iqk1yiw4	251	7	residue	residue	NN
cord-307860-iqk1yiw4	251	8	)	)	-RRB-
cord-307860-iqk1yiw4	251	9	[	[	-LRB-
cord-307860-iqk1yiw4	251	10	93	93	CD
cord-307860-iqk1yiw4	251	11	,	,	,
cord-307860-iqk1yiw4	251	12	99	99	CD
cord-307860-iqk1yiw4	251	13	]	]	-RRB-
cord-307860-iqk1yiw4	251	14	.	.	.
cord-307860-iqk1yiw4	252	1	There	there	EX
cord-307860-iqk1yiw4	252	2	is	be	VBZ
cord-307860-iqk1yiw4	252	3	one	one	CD
cord-307860-iqk1yiw4	252	4	cleavage	cleavage	NN
cord-307860-iqk1yiw4	252	5	at	at	IN
cord-307860-iqk1yiw4	252	6	the	the	DT
cord-307860-iqk1yiw4	252	7	S1	S1	NNP
cord-307860-iqk1yiw4	252	8	/	/	SYM
cord-307860-iqk1yiw4	252	9	S2	S2	NNP
cord-307860-iqk1yiw4	252	10	boundary	boundary	NN
cord-307860-iqk1yiw4	252	11	and	and	CC
cord-307860-iqk1yiw4	252	12	the	the	DT
cord-307860-iqk1yiw4	252	13	second	second	JJ
cord-307860-iqk1yiw4	252	14	one	one	CD
cord-307860-iqk1yiw4	253	1	S2′	S2′	NNP
cord-307860-iqk1yiw4	253	2	is	be	VBZ
cord-307860-iqk1yiw4	253	3	within	within	IN
cord-307860-iqk1yiw4	253	4	S2	S2	NNP
cord-307860-iqk1yiw4	253	5	upstream	upstream	RB
cord-307860-iqk1yiw4	253	6	of	of	IN
cord-307860-iqk1yiw4	253	7	the	the	DT
cord-307860-iqk1yiw4	253	8	putative	putative	JJ
cord-307860-iqk1yiw4	253	9	fusion	fusion	NN
cord-307860-iqk1yiw4	253	10	protein	protein	NN
cord-307860-iqk1yiw4	253	11	[	[	-LRB-
cord-307860-iqk1yiw4	253	12	94	94	CD
cord-307860-iqk1yiw4	253	13	,	,	,
cord-307860-iqk1yiw4	253	14	96	96	CD
cord-307860-iqk1yiw4	253	15	]	]	-RRB-
cord-307860-iqk1yiw4	253	16	.	.	.
cord-307860-iqk1yiw4	254	1	Some	some	DT
cord-307860-iqk1yiw4	254	2	researchers	researcher	NNS
cord-307860-iqk1yiw4	254	3	claim	claim	VBP
cord-307860-iqk1yiw4	254	4	that	that	IN
cord-307860-iqk1yiw4	254	5	there	there	EX
cord-307860-iqk1yiw4	254	6	are	be	VBP
cord-307860-iqk1yiw4	254	7	three	three	CD
cord-307860-iqk1yiw4	254	8	cleavage	cleavage	NN
cord-307860-iqk1yiw4	254	9	sites	site	NNS
cord-307860-iqk1yiw4	254	10	(	(	-LRB-
cord-307860-iqk1yiw4	254	11	S1	S1	NNP
cord-307860-iqk1yiw4	254	12	,	,	,
cord-307860-iqk1yiw4	254	13	S2	S2	NNP
cord-307860-iqk1yiw4	254	14	,	,	,
cord-307860-iqk1yiw4	254	15	and	and	CC
cord-307860-iqk1yiw4	254	16	S2′	s2′	NN
cord-307860-iqk1yiw4	254	17	)	)	-RRB-
cord-307860-iqk1yiw4	255	1	[	[	-LRB-
cord-307860-iqk1yiw4	255	2	100	100	CD
cord-307860-iqk1yiw4	255	3	]	]	-RRB-
cord-307860-iqk1yiw4	255	4	.	.	.
cord-307860-iqk1yiw4	256	1	The	the	DT
cord-307860-iqk1yiw4	256	2	S1	S1	NNP
cord-307860-iqk1yiw4	256	3	subunit	subunit	NN
cord-307860-iqk1yiw4	256	4	harbors	harbor	VBZ
cord-307860-iqk1yiw4	256	5	the	the	DT
cord-307860-iqk1yiw4	256	6	receptor	receptor	NN
cord-307860-iqk1yiw4	256	7	binding	bind	VBG
cord-307860-iqk1yiw4	256	8	domain	domain	NN
cord-307860-iqk1yiw4	256	9	(	(	-LRB-
cord-307860-iqk1yiw4	256	10	RBD	RBD	NNP
cord-307860-iqk1yiw4	256	11	)	)	-RRB-
cord-307860-iqk1yiw4	256	12	which	which	WDT
cord-307860-iqk1yiw4	256	13	contains	contain	VBZ
cord-307860-iqk1yiw4	256	14	the	the	DT
cord-307860-iqk1yiw4	256	15	core	core	NN
cord-307860-iqk1yiw4	256	16	and	and	CC
cord-307860-iqk1yiw4	256	17	receptor	receptor	NN
cord-307860-iqk1yiw4	256	18	-	-	HYPH
cord-307860-iqk1yiw4	256	19	binding	bind	VBG
cord-307860-iqk1yiw4	256	20	motif	motif	NN
cord-307860-iqk1yiw4	256	21	(	(	-LRB-
cord-307860-iqk1yiw4	256	22	RBM	RBM	NNP
cord-307860-iqk1yiw4	256	23	)	)	-RRB-
cord-307860-iqk1yiw4	256	24	[	[	-LRB-
cord-307860-iqk1yiw4	256	25	101	101	CD
cord-307860-iqk1yiw4	256	26	]	]	-RRB-
cord-307860-iqk1yiw4	256	27	.	.	.
cord-307860-iqk1yiw4	257	1	The	the	DT
cord-307860-iqk1yiw4	257	2	S1	s1	NN
cord-307860-iqk1yiw4	257	3	subunit	subunit	NN
cord-307860-iqk1yiw4	257	4	binds	bind	VBZ
cord-307860-iqk1yiw4	257	5	the	the	DT
cord-307860-iqk1yiw4	257	6	peptidase	peptidase	NN
cord-307860-iqk1yiw4	257	7	domain	domain	NN
cord-307860-iqk1yiw4	257	8	of	of	IN
cord-307860-iqk1yiw4	257	9	the	the	DT
cord-307860-iqk1yiw4	257	10	human	human	JJ
cord-307860-iqk1yiw4	257	11	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	257	12	.	.	.
cord-307860-iqk1yiw4	258	1	Then	then	RB
cord-307860-iqk1yiw4	258	2	,	,	,
cord-307860-iqk1yiw4	258	3	the	the	DT
cord-307860-iqk1yiw4	258	4	internalization	internalization	NN
cord-307860-iqk1yiw4	258	5	of	of	IN
cord-307860-iqk1yiw4	258	6	the	the	DT
cord-307860-iqk1yiw4	258	7	virus	virus	NN
cord-307860-iqk1yiw4	258	8	particle	particle	NN
cord-307860-iqk1yiw4	258	9	into	into	IN
cord-307860-iqk1yiw4	258	10	the	the	DT
cord-307860-iqk1yiw4	258	11	endosomes	endosome	NNS
cord-307860-iqk1yiw4	258	12	causes	cause	VBZ
cord-307860-iqk1yiw4	258	13	conformational	conformational	JJ
cord-307860-iqk1yiw4	258	14	changes	change	NNS
cord-307860-iqk1yiw4	258	15	of	of	IN
cord-307860-iqk1yiw4	258	16	the	the	DT
cord-307860-iqk1yiw4	258	17	S1	S1	NNP
cord-307860-iqk1yiw4	258	18	[	[	-LRB-
cord-307860-iqk1yiw4	258	19	35	35	CD
cord-307860-iqk1yiw4	258	20	,	,	,
cord-307860-iqk1yiw4	258	21	102	102	CD
cord-307860-iqk1yiw4	258	22	]	]	-RRB-
cord-307860-iqk1yiw4	258	23	.	.	.
cord-307860-iqk1yiw4	259	1	The	the	DT
cord-307860-iqk1yiw4	259	2	proteolysis	proteolysis	NN
cord-307860-iqk1yiw4	259	3	by	by	IN
cord-307860-iqk1yiw4	259	4	the	the	DT
cord-307860-iqk1yiw4	259	5	cathepsin	cathepsin	NN
cord-307860-iqk1yiw4	259	6	CTSL	CTSL	NNP
cord-307860-iqk1yiw4	259	7	(	(	-LRB-
cord-307860-iqk1yiw4	259	8	E.C.	E.C.	NNP
cord-307860-iqk1yiw4	259	9	3.4.22.15	3.4.22.15	CD
cord-307860-iqk1yiw4	259	10	;	;	:
cord-307860-iqk1yiw4	259	11	UniProtKB	uniprotkb	CD
cord-307860-iqk1yiw4	259	12	P07711	P07711	NNP
cord-307860-iqk1yiw4	259	13	)	)	-RRB-
cord-307860-iqk1yiw4	259	14	reveals	reveal	VBZ
cord-307860-iqk1yiw4	259	15	the	the	DT
cord-307860-iqk1yiw4	259	16	S2	S2	NNP
cord-307860-iqk1yiw4	259	17	subunit	subunit	NN
cord-307860-iqk1yiw4	259	18	which	which	WDT
cord-307860-iqk1yiw4	259	19	mediates	mediate	VBZ
cord-307860-iqk1yiw4	259	20	the	the	DT
cord-307860-iqk1yiw4	259	21	virus	virus	NN
cord-307860-iqk1yiw4	259	22	-	-	HYPH
cord-307860-iqk1yiw4	259	23	cell	cell	NN
cord-307860-iqk1yiw4	259	24	membrane	membrane	NN
cord-307860-iqk1yiw4	259	25	fusion	fusion	NN
cord-307860-iqk1yiw4	259	26	[	[	-LRB-
cord-307860-iqk1yiw4	259	27	2	2	CD
cord-307860-iqk1yiw4	259	28	,	,	,
cord-307860-iqk1yiw4	259	29	[	[	-LRB-
cord-307860-iqk1yiw4	259	30	103	103	CD
cord-307860-iqk1yiw4	259	31	]	]	-RRB-
cord-307860-iqk1yiw4	259	32	[	[	-LRB-
cord-307860-iqk1yiw4	259	33	104	104	CD
cord-307860-iqk1yiw4	259	34	]	]	-RRB-
cord-307860-iqk1yiw4	259	35	[	[	-LRB-
cord-307860-iqk1yiw4	259	36	105	105	CD
cord-307860-iqk1yiw4	259	37	]	]	-RRB-
cord-307860-iqk1yiw4	259	38	.	.	.
cord-307860-iqk1yiw4	260	1	Herein	herein	RB
cord-307860-iqk1yiw4	260	2	,	,	,
cord-307860-iqk1yiw4	260	3	a	a	DT
cord-307860-iqk1yiw4	260	4	comparison	comparison	NN
cord-307860-iqk1yiw4	260	5	of	of	IN
cord-307860-iqk1yiw4	260	6	the	the	DT
cord-307860-iqk1yiw4	260	7	S1	S1	NNP
cord-307860-iqk1yiw4	260	8	/	/	SYM
cord-307860-iqk1yiw4	260	9	S2	S2	NNP
cord-307860-iqk1yiw4	260	10	and	and	CC
cord-307860-iqk1yiw4	260	11	S2′	s2′	JJ
cord-307860-iqk1yiw4	260	12	cleavage	cleavage	NN
cord-307860-iqk1yiw4	260	13	sites	site	NNS
cord-307860-iqk1yiw4	260	14	of	of	IN
cord-307860-iqk1yiw4	260	15	the	the	DT
cord-307860-iqk1yiw4	260	16	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	260	17	and	and	CC
cord-307860-iqk1yiw4	260	18	SARS	SARS	NNP
cord-307860-iqk1yiw4	260	19	-	-	HYPH
cord-307860-iqk1yiw4	260	20	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	260	21	was	be	VBD
cord-307860-iqk1yiw4	260	22	made	make	VBN
cord-307860-iqk1yiw4	260	23	[	[	-LRB-
cord-307860-iqk1yiw4	260	24	93	93	CD
cord-307860-iqk1yiw4	260	25	]	]	-RRB-
cord-307860-iqk1yiw4	260	26	.	.	.
cord-307860-iqk1yiw4	261	1	The	the	DT
cord-307860-iqk1yiw4	261	2	multiple	multiple	JJ
cord-307860-iqk1yiw4	261	3	sequence	sequence	NN
cord-307860-iqk1yiw4	261	4	alignment	alignment	NN
cord-307860-iqk1yiw4	261	5	of	of	IN
cord-307860-iqk1yiw4	261	6	the	the	DT
cord-307860-iqk1yiw4	261	7	different	different	JJ
cord-307860-iqk1yiw4	261	8	SARS	SARS	NNP
cord-307860-iqk1yiw4	261	9	-	-	HYPH
cord-307860-iqk1yiw4	261	10	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	261	11	S	S	NNP
cord-307860-iqk1yiw4	261	12	glycoprotein	glycoprotein	NN
cord-307860-iqk1yiw4	261	13	with	with	IN
cord-307860-iqk1yiw4	261	14	their	-PRON-	PRP$
cord-307860-iqk1yiw4	261	15	counterparts	counterpart	NNS
cord-307860-iqk1yiw4	261	16	of	of	IN
cord-307860-iqk1yiw4	261	17	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	261	18	described	describe	VBN
cord-307860-iqk1yiw4	261	19	by	by	IN
cord-307860-iqk1yiw4	261	20	(	(	-LRB-
cord-307860-iqk1yiw4	261	21	Figs	Figs	NNP
cord-307860-iqk1yiw4	261	22	.	.	.
cord-307860-iqk1yiw4	261	23	6	6	CD
cord-307860-iqk1yiw4	261	24	,	,	,
cord-307860-iqk1yiw4	261	25	7	7	CD
cord-307860-iqk1yiw4	261	26	)	)	-RRB-
cord-307860-iqk1yiw4	261	27	.	.	.
cord-307860-iqk1yiw4	262	1	The	the	DT
cord-307860-iqk1yiw4	262	2	first	first	JJ
cord-307860-iqk1yiw4	262	3	striking	striking	JJ
cord-307860-iqk1yiw4	262	4	difference	difference	NN
cord-307860-iqk1yiw4	262	5	between	between	IN
cord-307860-iqk1yiw4	262	6	the	the	DT
cord-307860-iqk1yiw4	262	7	analyzed	analyze	VBN
cord-307860-iqk1yiw4	262	8	S	S	NNP
cord-307860-iqk1yiw4	262	9	'	'	''
cord-307860-iqk1yiw4	262	10	SARS	SARS	NNP
cord-307860-iqk1yiw4	262	11	-	-	HYPH
cord-307860-iqk1yiw4	262	12	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	262	13	concerns	concern	VBZ
cord-307860-iqk1yiw4	262	14	the	the	DT
cord-307860-iqk1yiw4	262	15	S1	S1	NNP
cord-307860-iqk1yiw4	262	16	/	/	SYM
cord-307860-iqk1yiw4	262	17	S2	S2	NNP
cord-307860-iqk1yiw4	262	18	cleavage	cleavage	NN
cord-307860-iqk1yiw4	262	19	site	site	NN
cord-307860-iqk1yiw4	262	20	.	.	.
cord-307860-iqk1yiw4	263	1	Thus	thus	RB
cord-307860-iqk1yiw4	263	2	,	,	,
cord-307860-iqk1yiw4	263	3	only	only	RB
cord-307860-iqk1yiw4	263	4	some	some	DT
cord-307860-iqk1yiw4	263	5	PDB	PDB	NNP
cord-307860-iqk1yiw4	263	6	entries	entry	NNS
cord-307860-iqk1yiw4	263	7	(	(	-LRB-
cord-307860-iqk1yiw4	263	8	6XR8/6XRA	6xr8/6xra	CD
cord-307860-iqk1yiw4	263	9	,	,	,
cord-307860-iqk1yiw4	263	10	7C2L	7c2l	CD
cord-307860-iqk1yiw4	263	11	,	,	,
cord-307860-iqk1yiw4	263	12	and	and	CC
cord-307860-iqk1yiw4	263	13	6XCN/6XCM	6xcn/6xcm	CD
cord-307860-iqk1yiw4	263	14	)	)	-RRB-
cord-307860-iqk1yiw4	263	15	show	show	VBP
cord-307860-iqk1yiw4	263	16	the	the	DT
cord-307860-iqk1yiw4	263	17	PPC	ppc	NN
cord-307860-iqk1yiw4	263	18	or	or	CC
cord-307860-iqk1yiw4	263	19	furin	furin	NN
cord-307860-iqk1yiw4	263	20	cleavage	cleavage	NN
cord-307860-iqk1yiw4	263	21	motif	motif	NN
cord-307860-iqk1yiw4	263	22	RRAR↓	rrar↓	XX
cord-307860-iqk1yiw4	263	23	[	[	-LRB-
cord-307860-iqk1yiw4	263	24	106	106	CD
cord-307860-iqk1yiw4	263	25	]	]	-RRB-
cord-307860-iqk1yiw4	263	26	.	.	.
cord-307860-iqk1yiw4	264	1	Moreover	moreover	RB
cord-307860-iqk1yiw4	264	2	,	,	,
cord-307860-iqk1yiw4	264	3	the	the	DT
cord-307860-iqk1yiw4	264	4	furin	furin	NN
cord-307860-iqk1yiw4	264	5	cleavage	cleavage	NN
cord-307860-iqk1yiw4	264	6	motif	motif	NN
cord-307860-iqk1yiw4	264	7	from	from	IN
cord-307860-iqk1yiw4	264	8	the	the	DT
cord-307860-iqk1yiw4	264	9	S1	S1	NNP
cord-307860-iqk1yiw4	264	10	/	/	SYM
cord-307860-iqk1yiw4	264	11	S2	S2	NNP
cord-307860-iqk1yiw4	264	12	sequence	sequence	NN
cord-307860-iqk1yiw4	264	13	of	of	IN
cord-307860-iqk1yiw4	264	14	the	the	DT
cord-307860-iqk1yiw4	264	15	SARS	SARS	NNP
cord-307860-iqk1yiw4	264	16	-	-	HYPH
cord-307860-iqk1yiw4	264	17	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	264	18	is	be	VBZ
cord-307860-iqk1yiw4	264	19	more	more	RBR
cord-307860-iqk1yiw4	264	20	similar	similar	JJ
cord-307860-iqk1yiw4	264	21	to	to	IN
cord-307860-iqk1yiw4	264	22	its	-PRON-	PRP$
cord-307860-iqk1yiw4	264	23	HCoV	HCoV	NNP
cord-307860-iqk1yiw4	264	24	-	-	HYPH
cord-307860-iqk1yiw4	264	25	OC43	OC43	NNP
cord-307860-iqk1yiw4	264	26	counterpart	counterpart	NN
cord-307860-iqk1yiw4	264	27	than	than	IN
cord-307860-iqk1yiw4	264	28	to	to	IN
cord-307860-iqk1yiw4	264	29	furin	furin	NN
cord-307860-iqk1yiw4	264	30	cleavage	cleavage	NN
cord-307860-iqk1yiw4	264	31	motif	motif	NN
cord-307860-iqk1yiw4	264	32	of	of	IN
cord-307860-iqk1yiw4	264	33	the	the	DT
cord-307860-iqk1yiw4	264	34	SARS	SARS	NNP
cord-307860-iqk1yiw4	264	35	-	-	HYPH
cord-307860-iqk1yiw4	264	36	CoV	CoV	NNP
cord-307860-iqk1yiw4	264	37	and	and	CC
cord-307860-iqk1yiw4	264	38	MERS	MERS	NNP
cord-307860-iqk1yiw4	265	1	-CoV.	-cov.	ADD
cord-307860-iqk1yiw4	266	1	In	in	IN
cord-307860-iqk1yiw4	266	2	contrast	contrast	NN
cord-307860-iqk1yiw4	266	3	,	,	,
cord-307860-iqk1yiw4	266	4	the	the	DT
cord-307860-iqk1yiw4	266	5	S2′cleavage	s2′cleavage	NN
cord-307860-iqk1yiw4	266	6	site	site	NN
cord-307860-iqk1yiw4	266	7	sequence	sequence	NN
cord-307860-iqk1yiw4	266	8	of	of	IN
cord-307860-iqk1yiw4	266	9	all	all	DT
cord-307860-iqk1yiw4	266	10	SARS	SARS	NNP
cord-307860-iqk1yiw4	266	11	-	-	HYPH
cord-307860-iqk1yiw4	266	12	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	266	13	PDB	PDB	NNP
cord-307860-iqk1yiw4	266	14	entries	entry	NNS
cord-307860-iqk1yiw4	266	15	analyzed	analyze	VBN
cord-307860-iqk1yiw4	266	16	has	have	VBZ
cord-307860-iqk1yiw4	266	17	the	the	DT
cord-307860-iqk1yiw4	266	18	furin	furin	NN
cord-307860-iqk1yiw4	266	19	cleavage	cleavage	NN
cord-307860-iqk1yiw4	266	20	motif	motif	NN
cord-307860-iqk1yiw4	266	21	similar	similar	JJ
cord-307860-iqk1yiw4	266	22	to	to	IN
cord-307860-iqk1yiw4	266	23	its	-PRON-	PRP$
cord-307860-iqk1yiw4	266	24	SARS	SARS	NNP
cord-307860-iqk1yiw4	266	25	-	-	HYPH
cord-307860-iqk1yiw4	266	26	CoV	CoV	NNP
cord-307860-iqk1yiw4	266	27	counterpart	counterpart	NN
cord-307860-iqk1yiw4	266	28	.	.	.
cord-307860-iqk1yiw4	267	1	The	the	DT
cord-307860-iqk1yiw4	267	2	phylogenetic	phylogenetic	JJ
cord-307860-iqk1yiw4	267	3	tree	tree	NN
cord-307860-iqk1yiw4	267	4	(	(	-LRB-
cord-307860-iqk1yiw4	267	5	cladogram	cladogram	NN
cord-307860-iqk1yiw4	267	6	)	)	-RRB-
cord-307860-iqk1yiw4	267	7	of	of	IN
cord-307860-iqk1yiw4	267	8	the	the	DT
cord-307860-iqk1yiw4	267	9	S	S	NNP
cord-307860-iqk1yiw4	267	10	sequences	sequence	NNS
cord-307860-iqk1yiw4	267	11	analyzed	analyze	VBD
cord-307860-iqk1yiw4	267	12	shows	show	VBZ
cord-307860-iqk1yiw4	267	13	that	that	IN
cord-307860-iqk1yiw4	267	14	the	the	DT
cord-307860-iqk1yiw4	267	15	SARS	SARS	NNP
cord-307860-iqk1yiw4	267	16	-	-	HYPH
cord-307860-iqk1yiw4	267	17	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	267	18	S	S	NNP
cord-307860-iqk1yiw4	267	19	is	be	VBZ
cord-307860-iqk1yiw4	267	20	closer	close	JJR
cord-307860-iqk1yiw4	267	21	to	to	IN
cord-307860-iqk1yiw4	267	22	SARS	SARS	NNP
cord-307860-iqk1yiw4	267	23	-	-	HYPH
cord-307860-iqk1yiw4	267	24	CoV	CoV	NNP
cord-307860-iqk1yiw4	267	25	S	S	NNP
cord-307860-iqk1yiw4	267	26	,	,	,
cord-307860-iqk1yiw4	267	27	but	but	CC
cord-307860-iqk1yiw4	267	28	the	the	DT
cord-307860-iqk1yiw4	267	29	differences	difference	NNS
cord-307860-iqk1yiw4	267	30	observed	observe	VBN
cord-307860-iqk1yiw4	267	31	between	between	IN
cord-307860-iqk1yiw4	267	32	the	the	DT
cord-307860-iqk1yiw4	267	33	nine	nine	CD
cord-307860-iqk1yiw4	267	34	SARS	SARS	NNP
cord-307860-iqk1yiw4	267	35	-	-	HYPH
cord-307860-iqk1yiw4	267	36	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	267	37	S	S	NNP
cord-307860-iqk1yiw4	267	38	sequences	sequence	NNS
cord-307860-iqk1yiw4	267	39	are	be	VBP
cord-307860-iqk1yiw4	267	40	reflected	reflect	VBN
cord-307860-iqk1yiw4	267	41	in	in	IN
cord-307860-iqk1yiw4	267	42	the	the	DT
cord-307860-iqk1yiw4	267	43	evolutionary	evolutionary	JJ
cord-307860-iqk1yiw4	267	44	relationship	relationship	NN
cord-307860-iqk1yiw4	267	45	(	(	-LRB-
cord-307860-iqk1yiw4	267	46	Fig	Fig	NNP
cord-307860-iqk1yiw4	267	47	.	.	.
cord-307860-iqk1yiw4	267	48	8)	8)	NNP
cord-307860-iqk1yiw4	267	49	.	.	.
cord-307860-iqk1yiw4	268	1	There	there	EX
cord-307860-iqk1yiw4	268	2	are	be	VBP
cord-307860-iqk1yiw4	268	3	22	22	CD
cord-307860-iqk1yiw4	268	4	published	publish	VBN
cord-307860-iqk1yiw4	268	5	structures	structure	NNS
cord-307860-iqk1yiw4	268	6	of	of	IN
cord-307860-iqk1yiw4	268	7	SARS	SARS	NNP
cord-307860-iqk1yiw4	268	8	-	-	HYPH
cord-307860-iqk1yiw4	268	9	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	268	10	S	S	NNP
cord-307860-iqk1yiw4	268	11	glycoprotein	glycoprotein	NN
cord-307860-iqk1yiw4	268	12	retrieved	retrieve	VBD
cord-307860-iqk1yiw4	268	13	from	from	IN
cord-307860-iqk1yiw4	268	14	the	the	DT
cord-307860-iqk1yiw4	268	15	PDB	PDB	NNP
cord-307860-iqk1yiw4	268	16	.	.	.
cord-307860-iqk1yiw4	269	1	Among	among	IN
cord-307860-iqk1yiw4	269	2	them	-PRON-	PRP
cord-307860-iqk1yiw4	269	3	,	,	,
cord-307860-iqk1yiw4	269	4	seven	seven	CD
cord-307860-iqk1yiw4	269	5	are	be	VBP
cord-307860-iqk1yiw4	269	6	S	s	NN
cord-307860-iqk1yiw4	269	7	glycoprotein	glycoprotein	NN
cord-307860-iqk1yiw4	269	8	structures	structure	NNS
cord-307860-iqk1yiw4	269	9	(	(	-LRB-
cord-307860-iqk1yiw4	269	10	PDD	PDD	NNP
cord-307860-iqk1yiw4	269	11	ID(s	ID(s	NNP
cord-307860-iqk1yiw4	269	12	)	)	-RRB-
cord-307860-iqk1yiw4	269	13	6VXX	6vxx	CD
cord-307860-iqk1yiw4	269	14	,	,	,
cord-307860-iqk1yiw4	269	15	6VYB	6vyb	CD
cord-307860-iqk1yiw4	269	16	,	,	,
cord-307860-iqk1yiw4	269	17	6VSB	6vsb	CD
cord-307860-iqk1yiw4	269	18	,	,	,
cord-307860-iqk1yiw4	269	19	6LXT	6LXT	NNP
cord-307860-iqk1yiw4	269	20	,	,	,
cord-307860-iqk1yiw4	269	21	6Z97	6z97	CD
cord-307860-iqk1yiw4	269	22	,	,	,
cord-307860-iqk1yiw4	269	23	6XR8	6xr8	CD
cord-307860-iqk1yiw4	269	24	,	,	,
cord-307860-iqk1yiw4	269	25	and	and	CC
cord-307860-iqk1yiw4	269	26	6RA	6ra	CD
cord-307860-iqk1yiw4	269	27	)	)	-RRB-
cord-307860-iqk1yiw4	269	28	and	and	CC
cord-307860-iqk1yiw4	269	29	four	four	CD
cord-307860-iqk1yiw4	269	30	structures	structure	NNS
cord-307860-iqk1yiw4	269	31	are	be	VBP
cord-307860-iqk1yiw4	269	32	co	co	JJ
cord-307860-iqk1yiw4	269	33	-	-	JJ
cord-307860-iqk1yiw4	269	34	crystallized	crystallize	VBN
cord-307860-iqk1yiw4	270	1	with	with	IN
cord-307860-iqk1yiw4	270	2	the	the	DT
cord-307860-iqk1yiw4	270	3	human	human	JJ
cord-307860-iqk1yiw4	270	4	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	270	5	receptor	receptor	NN
cord-307860-iqk1yiw4	270	6	(	(	-LRB-
cord-307860-iqk1yiw4	270	7	PDB	PDB	NNP
cord-307860-iqk1yiw4	270	8	ID(s	ID(s	NNP
cord-307860-iqk1yiw4	270	9	)	)	-RRB-
cord-307860-iqk1yiw4	270	10	6M0J	6m0j	CD
cord-307860-iqk1yiw4	270	11	,	,	,
cord-307860-iqk1yiw4	270	12	6LZG	6lzg	CD
cord-307860-iqk1yiw4	270	13	,	,	,
cord-307860-iqk1yiw4	270	14	6M17	6m17	CD
cord-307860-iqk1yiw4	270	15	,	,	,
cord-307860-iqk1yiw4	270	16	and	and	CC
cord-307860-iqk1yiw4	270	17	6VW1	6vw1	CD
cord-307860-iqk1yiw4	270	18	)	)	-RRB-
cord-307860-iqk1yiw4	270	19	.	.	.
cord-307860-iqk1yiw4	271	1	Out	out	IN
cord-307860-iqk1yiw4	271	2	of	of	IN
cord-307860-iqk1yiw4	271	3	32	32	CD
cord-307860-iqk1yiw4	271	4	SARS	SARS	NNP
cord-307860-iqk1yiw4	271	5	-	-	HYPH
cord-307860-iqk1yiw4	271	6	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	271	7	S	S	NNP
cord-307860-iqk1yiw4	271	8	glycoprotein	glycoprotein	NN
cord-307860-iqk1yiw4	271	9	structures	structure	NNS
cord-307860-iqk1yiw4	271	10	co	co	VBP
cord-307860-iqk1yiw4	271	11	-	-	VBD
cord-307860-iqk1yiw4	271	12	crystallized	crystallize	VBN
cord-307860-iqk1yiw4	271	13	with	with	IN
cord-307860-iqk1yiw4	271	14	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	271	15	antibodies	antibody	NNS
cord-307860-iqk1yiw4	271	16	,	,	,
cord-307860-iqk1yiw4	271	17	eleven	eleven	CD
cord-307860-iqk1yiw4	271	18	has	have	VBZ
cord-307860-iqk1yiw4	271	19	been	be	VBN
cord-307860-iqk1yiw4	271	20	published	publish	VBN
cord-307860-iqk1yiw4	271	21	(	(	-LRB-
cord-307860-iqk1yiw4	272	1	PDB	PDB	NNP
cord-307860-iqk1yiw4	272	2	ID(s	ID(s	NNP
cord-307860-iqk1yiw4	272	3	)	)	-RRB-
cord-307860-iqk1yiw4	272	4	6W41	6w41	CD
cord-307860-iqk1yiw4	272	5	,	,	,
cord-307860-iqk1yiw4	272	6	7BZ5	7bz5	CD
cord-307860-iqk1yiw4	272	7	,	,	,
cord-307860-iqk1yiw4	272	8	7C01	7c01	CD
cord-307860-iqk1yiw4	272	9	,	,	,
cord-307860-iqk1yiw4	272	10	7BWJ	7BWJ	NNP
cord-307860-iqk1yiw4	272	11	,	,	,
cord-307860-iqk1yiw4	272	12	7BYR	7BYR	NNP
cord-307860-iqk1yiw4	272	13	,	,	,
cord-307860-iqk1yiw4	272	14	6XCM	6xcm	UH
cord-307860-iqk1yiw4	272	15	,	,	,
cord-307860-iqk1yiw4	272	16	6XCN	6XCN	NNP
cord-307860-iqk1yiw4	272	17	,	,	,
cord-307860-iqk1yiw4	272	18	6XCA	6XCA	NNP
cord-307860-iqk1yiw4	272	19	,	,	,
cord-307860-iqk1yiw4	272	20	7C2L	7c2l	CD
cord-307860-iqk1yiw4	272	21	,	,	,
cord-307860-iqk1yiw4	272	22	6XDG	6XDG	NNP
cord-307860-iqk1yiw4	272	23	,	,	,
cord-307860-iqk1yiw4	272	24	and	and	CC
cord-307860-iqk1yiw4	272	25	6YOR	6yor	LS
cord-307860-iqk1yiw4	272	26	)	)	-RRB-
cord-307860-iqk1yiw4	273	1	(	(	-LRB-
cord-307860-iqk1yiw4	273	2	Fig	Fig	NNP
cord-307860-iqk1yiw4	273	3	.	.	.
cord-307860-iqk1yiw4	273	4	9	9	CD
cord-307860-iqk1yiw4	273	5	)	)	-RRB-
cord-307860-iqk1yiw4	273	6	.	.	.
cord-307860-iqk1yiw4	274	1	Cai	Cai	NNP
cord-307860-iqk1yiw4	274	2	et	et	FW
cord-307860-iqk1yiw4	274	3	al	al	NNP
cord-307860-iqk1yiw4	274	4	.	.	.
cord-307860-iqk1yiw4	275	1	(	(	-LRB-
cord-307860-iqk1yiw4	275	2	PDB	PDB	NNP
cord-307860-iqk1yiw4	275	3	ID(s	ID(s	NNP
cord-307860-iqk1yiw4	275	4	)	)	-RRB-
cord-307860-iqk1yiw4	275	5	6XR8	6xr8	CD
cord-307860-iqk1yiw4	275	6	and	and	CC
cord-307860-iqk1yiw4	275	7	6XRA	6xra	LS
cord-307860-iqk1yiw4	275	8	)	)	-RRB-
cord-307860-iqk1yiw4	275	9	assume	assume	VBP
cord-307860-iqk1yiw4	275	10	a	a	DT
cord-307860-iqk1yiw4	275	11	protective	protective	JJ
cord-307860-iqk1yiw4	275	12	role	role	NN
cord-307860-iqk1yiw4	275	13	of	of	IN
cord-307860-iqk1yiw4	275	14	the	the	DT
cord-307860-iqk1yiw4	275	15	S2	S2	NNP
cord-307860-iqk1yiw4	275	16	post	post	JJ
cord-307860-iqk1yiw4	275	17	-	-	JJ
cord-307860-iqk1yiw4	275	18	fusion	fusion	JJ
cord-307860-iqk1yiw4	275	19	structure	structure	NN
cord-307860-iqk1yiw4	275	20	that	that	WDT
cord-307860-iqk1yiw4	275	21	could	could	MD
cord-307860-iqk1yiw4	275	22	elicit	elicit	VB
cord-307860-iqk1yiw4	275	23	the	the	DT
cord-307860-iqk1yiw4	275	24	non	non	JJ
cord-307860-iqk1yiw4	275	25	-	-	JJ
cord-307860-iqk1yiw4	275	26	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	275	27	antibodies	antibody	NNS
cord-307860-iqk1yiw4	275	28	to	to	TO
cord-307860-iqk1yiw4	275	29	evade	evade	VB
cord-307860-iqk1yiw4	275	30	the	the	DT
cord-307860-iqk1yiw4	275	31	host	host	NN
cord-307860-iqk1yiw4	275	32	immune	immune	JJ
cord-307860-iqk1yiw4	275	33	system	system	NN
cord-307860-iqk1yiw4	275	34	[	[	-LRB-
cord-307860-iqk1yiw4	275	35	40	40	CD
cord-307860-iqk1yiw4	275	36	]	]	-RRB-
cord-307860-iqk1yiw4	275	37	.	.	.
cord-307860-iqk1yiw4	276	1	Also	also	RB
cord-307860-iqk1yiw4	276	2	,	,	,
cord-307860-iqk1yiw4	276	3	the	the	DT
cord-307860-iqk1yiw4	276	4	authors	author	NNS
cord-307860-iqk1yiw4	276	5	identify	identify	VBP
cord-307860-iqk1yiw4	276	6	a	a	DT
cord-307860-iqk1yiw4	276	7	fusion	fusion	NN
cord-307860-iqk1yiw4	276	8	peptide	peptide	NN
cord-307860-iqk1yiw4	276	9	proximal	proximal	JJ
cord-307860-iqk1yiw4	276	10	region	region	NN
cord-307860-iqk1yiw4	276	11	(	(	-LRB-
cord-307860-iqk1yiw4	276	12	FPRP	FPRP	NNP
cord-307860-iqk1yiw4	276	13	)	)	-RRB-
cord-307860-iqk1yiw4	276	14	with	with	IN
cord-307860-iqk1yiw4	276	15	a	a	DT
cord-307860-iqk1yiw4	276	16	critical	critical	JJ
cord-307860-iqk1yiw4	276	17	role	role	NN
cord-307860-iqk1yiw4	276	18	in	in	IN
cord-307860-iqk1yiw4	276	19	rearrangements	rearrangement	NNS
cord-307860-iqk1yiw4	276	20	of	of	IN
cord-307860-iqk1yiw4	276	21	S	s	NN
cord-307860-iqk1yiw4	276	22	protein	protein	NN
cord-307860-iqk1yiw4	276	23	and	and	CC
cord-307860-iqk1yiw4	276	24	membrane	membrane	NN
cord-307860-iqk1yiw4	276	25	fusion	fusion	NN
cord-307860-iqk1yiw4	276	26	,	,	,
cord-307860-iqk1yiw4	276	27	demonstrated	demonstrate	VBN
cord-307860-iqk1yiw4	276	28	by	by	IN
cord-307860-iqk1yiw4	276	29	a	a	DT
cord-307860-iqk1yiw4	276	30	mutation	mutation	NN
cord-307860-iqk1yiw4	276	31	D614	d614	CD
cord-307860-iqk1yiw4	276	32	G	g	NN
cord-307860-iqk1yiw4	276	33	that	that	WDT
cord-307860-iqk1yiw4	276	34	lead	lead	VBP
cord-307860-iqk1yiw4	276	35	to	to	IN
cord-307860-iqk1yiw4	276	36	more	more	RBR
cord-307860-iqk1yiw4	276	37	efficient	efficient	JJ
cord-307860-iqk1yiw4	276	38	cell	cell	NN
cord-307860-iqk1yiw4	276	39	entry	entry	NN
cord-307860-iqk1yiw4	276	40	.	.	.
cord-307860-iqk1yiw4	277	1	The	the	DT
cord-307860-iqk1yiw4	277	2	aspartic	aspartic	JJ
cord-307860-iqk1yiw4	277	3	acid	acid	NN
cord-307860-iqk1yiw4	277	4	(	(	-LRB-
cord-307860-iqk1yiw4	277	5	D614	D614	NNP
cord-307860-iqk1yiw4	277	6	)	)	-RRB-
cord-307860-iqk1yiw4	277	7	forms	form	VBZ
cord-307860-iqk1yiw4	277	8	a	a	DT
cord-307860-iqk1yiw4	277	9	salt	salt	NN
cord-307860-iqk1yiw4	277	10	bridge	bridge	NN
cord-307860-iqk1yiw4	277	11	with	with	IN
cord-307860-iqk1yiw4	277	12	the	the	DT
cord-307860-iqk1yiw4	277	13	lysine	lysine	NN
cord-307860-iqk1yiw4	277	14	(	(	-LRB-
cord-307860-iqk1yiw4	277	15	K854	K854	NNP
cord-307860-iqk1yiw4	277	16	)	)	-RRB-
cord-307860-iqk1yiw4	277	17	belonging	belong	VBG
cord-307860-iqk1yiw4	277	18	to	to	IN
cord-307860-iqk1yiw4	277	19	FPRP	FPRP	NNP
cord-307860-iqk1yiw4	277	20	[	[	-LRB-
cord-307860-iqk1yiw4	277	21	40	40	CD
cord-307860-iqk1yiw4	277	22	,	,	,
cord-307860-iqk1yiw4	277	23	[	[	-LRB-
cord-307860-iqk1yiw4	277	24	107	107	CD
cord-307860-iqk1yiw4	277	25	]	]	-RRB-
cord-307860-iqk1yiw4	277	26	[	[	-LRB-
cord-307860-iqk1yiw4	277	27	108	108	CD
cord-307860-iqk1yiw4	277	28	]	]	-RRB-
cord-307860-iqk1yiw4	277	29	[	[	-LRB-
cord-307860-iqk1yiw4	277	30	109	109	CD
cord-307860-iqk1yiw4	277	31	]	]	-RRB-
cord-307860-iqk1yiw4	277	32	.	.	.
cord-307860-iqk1yiw4	278	1	Barnes	Barnes	NNP
cord-307860-iqk1yiw4	278	2	et	et	NNP
cord-307860-iqk1yiw4	278	3	al	al	NNP
cord-307860-iqk1yiw4	278	4	.	.	.
cord-307860-iqk1yiw4	279	1	The	the	DT
cord-307860-iqk1yiw4	279	2	multiple	multiple	JJ
cord-307860-iqk1yiw4	279	3	sequence	sequence	NN
cord-307860-iqk1yiw4	279	4	alignment	alignment	NN
cord-307860-iqk1yiw4	279	5	of	of	IN
cord-307860-iqk1yiw4	279	6	SARS	SARS	NNP
cord-307860-iqk1yiw4	279	7	-	-	HYPH
cord-307860-iqk1yiw4	279	8	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	279	9	nucleocapsid	nucleocapsid	NN
cord-307860-iqk1yiw4	279	10	(	(	-LRB-
cord-307860-iqk1yiw4	279	11	N	n	NN
cord-307860-iqk1yiw4	279	12	)	)	-RRB-
cord-307860-iqk1yiw4	280	1	(	(	-LRB-
cord-307860-iqk1yiw4	280	2	PDB	PDB	NNP
cord-307860-iqk1yiw4	280	3	ID	ID	NNP
cord-307860-iqk1yiw4	280	4	6M3	6m3	CD
cord-307860-iqk1yiw4	280	5	M	M	NNP
cord-307860-iqk1yiw4	280	6	)	)	-RRB-
cord-307860-iqk1yiw4	281	1	and	and	CC
cord-307860-iqk1yiw4	281	2	HCoV	HCoV	NNP
cord-307860-iqk1yiw4	281	3	-	-	HYPH
cord-307860-iqk1yiw4	281	4	OC43	OC43	NNP
cord-307860-iqk1yiw4	282	1	(	(	-LRB-
cord-307860-iqk1yiw4	282	2	PDB	PDB	NNP
cord-307860-iqk1yiw4	282	3	ID	ID	NNP
cord-307860-iqk1yiw4	282	4	4KXJ	4kxj	CD
cord-307860-iqk1yiw4	282	5	)	)	-RRB-
cord-307860-iqk1yiw4	282	6	sequences	sequence	NNS
cord-307860-iqk1yiw4	282	7	(	(	-LRB-
cord-307860-iqk1yiw4	282	8	using	use	VBG
cord-307860-iqk1yiw4	282	9	the	the	DT
cord-307860-iqk1yiw4	282	10	Clustal	Clustal	NNP
cord-307860-iqk1yiw4	282	11	Omega	Omega	NNP
cord-307860-iqk1yiw4	282	12	program	program	NN
cord-307860-iqk1yiw4	282	13	)	)	-RRB-
cord-307860-iqk1yiw4	282	14	.	.	.
cord-307860-iqk1yiw4	283	1	The	the	DT
cord-307860-iqk1yiw4	283	2	residues	residue	NNS
cord-307860-iqk1yiw4	283	3	that	that	WDT
cord-307860-iqk1yiw4	283	4	interact	interact	VBP
cord-307860-iqk1yiw4	283	5	with	with	IN
cord-307860-iqk1yiw4	283	6	the	the	DT
cord-307860-iqk1yiw4	283	7	compound	compound	NN
cord-307860-iqk1yiw4	283	8	PJ34	PJ34	NNP
cord-307860-iqk1yiw4	283	9	are	be	VBP
cord-307860-iqk1yiw4	283	10	shown	show	VBN
cord-307860-iqk1yiw4	283	11	in	in	IN
cord-307860-iqk1yiw4	283	12	gray	gray	JJ
cord-307860-iqk1yiw4	283	13	background	background	NN
cord-307860-iqk1yiw4	283	14	,	,	,
cord-307860-iqk1yiw4	283	15	according	accord	VBG
cord-307860-iqk1yiw4	283	16	to	to	IN
cord-307860-iqk1yiw4	283	17	molecular	molecular	JJ
cord-307860-iqk1yiw4	283	18	docking	docking	NN
cord-307860-iqk1yiw4	283	19	results	result	NNS
cord-307860-iqk1yiw4	283	20	for	for	IN
cord-307860-iqk1yiw4	283	21	6M3	6m3	CD
cord-307860-iqk1yiw4	283	22	M	M	NNP
cord-307860-iqk1yiw4	283	23	and	and	CC
cord-307860-iqk1yiw4	283	24	according	accord	VBG
cord-307860-iqk1yiw4	283	25	to	to	IN
cord-307860-iqk1yiw4	283	26	Lin	Lin	NNP
cord-307860-iqk1yiw4	283	27	et	et	NNP
cord-307860-iqk1yiw4	283	28	al	al	NNP
cord-307860-iqk1yiw4	283	29	.	.	.
cord-307860-iqk1yiw4	284	1	findings	finding	NNS
cord-307860-iqk1yiw4	284	2	4KXJ	4kxj	CD
cord-307860-iqk1yiw4	284	3	;	;	:
cord-307860-iqk1yiw4	284	4	are	be	VBP
cord-307860-iqk1yiw4	284	5	considered	consider	VBN
cord-307860-iqk1yiw4	284	6	all	all	DT
cord-307860-iqk1yiw4	284	7	types	type	NNS
cord-307860-iqk1yiw4	284	8	of	of	IN
cord-307860-iqk1yiw4	284	9	interactions	interaction	NNS
cord-307860-iqk1yiw4	284	10	-	-	:
cord-307860-iqk1yiw4	284	11	van	van	NN
cord-307860-iqk1yiw4	284	12	der	der	NNP
cord-307860-iqk1yiw4	284	13	Waals	Waals	NNP
cord-307860-iqk1yiw4	284	14	,	,	,
cord-307860-iqk1yiw4	284	15	hydrogen	hydrogen	NN
cord-307860-iqk1yiw4	284	16	bonds	bond	NNS
cord-307860-iqk1yiw4	284	17	,	,	,
cord-307860-iqk1yiw4	284	18	carbon	carbon	NN
cord-307860-iqk1yiw4	284	19	hydrogen	hydrogen	NN
cord-307860-iqk1yiw4	284	20	bonds	bond	NNS
cord-307860-iqk1yiw4	284	21	,	,	,
cord-307860-iqk1yiw4	284	22	and	and	CC
cord-307860-iqk1yiw4	284	23	hydrophobic	hydrophobic	JJ
cord-307860-iqk1yiw4	284	24	interactions	interaction	NNS
cord-307860-iqk1yiw4	284	25	;	;	:
cord-307860-iqk1yiw4	284	26	the	the	DT
cord-307860-iqk1yiw4	284	27	striking	strike	VBG
cord-307860-iqk1yiw4	284	28	differences	difference	NNS
cord-307860-iqk1yiw4	284	29	between	between	IN
cord-307860-iqk1yiw4	284	30	the	the	DT
cord-307860-iqk1yiw4	284	31	two	two	CD
cord-307860-iqk1yiw4	284	32	N	n	CD
cord-307860-iqk1yiw4	284	33	sequences	sequence	NNS
cord-307860-iqk1yiw4	284	34	observed	observe	VBN
cord-307860-iqk1yiw4	284	35	by	by	IN
cord-307860-iqk1yiw4	284	36	the	the	DT
cord-307860-iqk1yiw4	284	37	Kang	Kang	NNP
cord-307860-iqk1yiw4	284	38	et	et	NNP
cord-307860-iqk1yiw4	284	39	al	al	NNP
cord-307860-iqk1yiw4	284	40	.	.	NNP
cord-307860-iqk1yiw4	284	41	are	be	VBP
cord-307860-iqk1yiw4	284	42	marked	mark	VBN
cord-307860-iqk1yiw4	284	43	in	in	IN
cord-307860-iqk1yiw4	284	44	yellow	yellow	JJ
cord-307860-iqk1yiw4	284	45	background	background	NN
cord-307860-iqk1yiw4	284	46	;	;	:
cord-307860-iqk1yiw4	284	47	the	the	DT
cord-307860-iqk1yiw4	284	48	AMP	amp	NN
cord-307860-iqk1yiw4	284	49	-	-	HYPH
cord-307860-iqk1yiw4	284	50	binding	bind	VBG
cord-307860-iqk1yiw4	284	51	residues	residue	NNS
cord-307860-iqk1yiw4	284	52	are	be	VBP
cord-307860-iqk1yiw4	284	53	underlined	underline	VBN
cord-307860-iqk1yiw4	284	54	;	;	:
cord-307860-iqk1yiw4	284	55	in	in	IN
cord-307860-iqk1yiw4	284	56	red	red	NN
cord-307860-iqk1yiw4	284	57	is	be	VBZ
cord-307860-iqk1yiw4	284	58	marked	mark	VBN
cord-307860-iqk1yiw4	284	59	the	the	DT
cord-307860-iqk1yiw4	284	60	Tyr	Tyr	NNP
cord-307860-iqk1yiw4	284	61	residue	residue	NN
cord-307860-iqk1yiw4	284	62	whose	whose	WP$
cord-307860-iqk1yiw4	284	63	mutation	mutation	NN
cord-307860-iqk1yiw4	284	64	Y110A	Y110A	NNP
cord-307860-iqk1yiw4	284	65	leads	lead	VBZ
cord-307860-iqk1yiw4	284	66	to	to	IN
cord-307860-iqk1yiw4	284	67	a	a	DT
cord-307860-iqk1yiw4	284	68	significant	significant	JJ
cord-307860-iqk1yiw4	284	69	decrease	decrease	NN
cord-307860-iqk1yiw4	284	70	of	of	IN
cord-307860-iqk1yiw4	284	71	Kd	Kd	NNP
cord-307860-iqk1yiw4	284	72	for	for	IN
cord-307860-iqk1yiw4	284	73	RNA	RNA	NNP
cord-307860-iqk1yiw4	284	74	binding	bind	VBG
cord-307860-iqk1yiw4	284	75	[	[	-LRB-
cord-307860-iqk1yiw4	284	76	33	33	CD
cord-307860-iqk1yiw4	284	77	]	]	-RRB-
cord-307860-iqk1yiw4	284	78	;	;	:
cord-307860-iqk1yiw4	284	79	with	with	IN
cord-307860-iqk1yiw4	284	80	dot	dot	NN
cord-307860-iqk1yiw4	284	81	"	"	''
cord-307860-iqk1yiw4	284	82	.	.	.
cord-307860-iqk1yiw4	285	1	"	"	``
cord-307860-iqk1yiw4	285	2	are	be	VBP
cord-307860-iqk1yiw4	285	3	marked	mark	VBN
cord-307860-iqk1yiw4	285	4	the	the	DT
cord-307860-iqk1yiw4	285	5	semi	semi	JJ
cord-307860-iqk1yiw4	285	6	-	-	JJ
cord-307860-iqk1yiw4	285	7	conservative	conservative	JJ
cord-307860-iqk1yiw4	285	8	replacements	replacement	NNS
cord-307860-iqk1yiw4	285	9	;	;	:
cord-307860-iqk1yiw4	285	10	with	with	IN
cord-307860-iqk1yiw4	285	11	colon	colon	NN
cord-307860-iqk1yiw4	285	12	"	"	''
cord-307860-iqk1yiw4	285	13	:	:	:
cord-307860-iqk1yiw4	285	14	"	"	``
cord-307860-iqk1yiw4	285	15	are	be	VBP
cord-307860-iqk1yiw4	285	16	marked	mark	VBN
cord-307860-iqk1yiw4	285	17	the	the	DT
cord-307860-iqk1yiw4	285	18	conservative	conservative	JJ
cord-307860-iqk1yiw4	285	19	replacements	replacement	NNS
cord-307860-iqk1yiw4	285	20	;	;	:
cord-307860-iqk1yiw4	285	21	with	with	IN
cord-307860-iqk1yiw4	285	22	"	"	``
cord-307860-iqk1yiw4	285	23	*	*	NFP
cord-307860-iqk1yiw4	285	24	"	"	''
cord-307860-iqk1yiw4	285	25	are	be	VBP
cord-307860-iqk1yiw4	285	26	marked	mark	VBN
cord-307860-iqk1yiw4	285	27	the	the	DT
cord-307860-iqk1yiw4	285	28	identities	identity	NNS
cord-307860-iqk1yiw4	285	29	of	of	IN
cord-307860-iqk1yiw4	285	30	the	the	DT
cord-307860-iqk1yiw4	285	31	residues	residue	NNS
cord-307860-iqk1yiw4	285	32	study	study	NN
cord-307860-iqk1yiw4	285	33	demonstrates	demonstrate	VBZ
cord-307860-iqk1yiw4	285	34	that	that	IN
cord-307860-iqk1yiw4	285	35	the	the	DT
cord-307860-iqk1yiw4	285	36	mutation	mutation	NN
cord-307860-iqk1yiw4	285	37	D614	d614	CD
cord-307860-iqk1yiw4	285	38	G	g	NN
cord-307860-iqk1yiw4	285	39	,	,	,
cord-307860-iqk1yiw4	285	40	a	a	DT
cord-307860-iqk1yiw4	285	41	mutation	mutation	NN
cord-307860-iqk1yiw4	285	42	that	that	WDT
cord-307860-iqk1yiw4	285	43	enhances	enhance	VBZ
cord-307860-iqk1yiw4	285	44	the	the	DT
cord-307860-iqk1yiw4	285	45	SARS	SARS	NNP
cord-307860-iqk1yiw4	285	46	-	-	HYPH
cord-307860-iqk1yiw4	285	47	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	285	48	transmissibility	transmissibility	NN
cord-307860-iqk1yiw4	285	49	,	,	,
cord-307860-iqk1yiw4	285	50	is	be	VBZ
cord-307860-iqk1yiw4	285	51	unlikely	unlikely	JJ
cord-307860-iqk1yiw4	285	52	to	to	TO
cord-307860-iqk1yiw4	285	53	affect	affect	VB
cord-307860-iqk1yiw4	285	54	antibodies	antibody	NNS
cord-307860-iqk1yiw4	285	55	from	from	IN
cord-307860-iqk1yiw4	285	56	recovering	recover	VBG
cord-307860-iqk1yiw4	285	57	COVID-19	covid-19	CD
cord-307860-iqk1yiw4	285	58	patients	patient	NNS
cord-307860-iqk1yiw4	285	59	included	include	VBN
cord-307860-iqk1yiw4	285	60	in	in	IN
cord-307860-iqk1yiw4	285	61	the	the	DT
cord-307860-iqk1yiw4	285	62	study	study	NN
cord-307860-iqk1yiw4	285	63	.	.	.
cord-307860-iqk1yiw4	286	1	[	[	-LRB-
cord-307860-iqk1yiw4	286	2	24	24	CD
cord-307860-iqk1yiw4	286	3	]	]	-RRB-
cord-307860-iqk1yiw4	286	4	.	.	.
cord-307860-iqk1yiw4	287	1	The	the	DT
cord-307860-iqk1yiw4	287	2	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	287	3	(	(	-LRB-
cord-307860-iqk1yiw4	287	4	E.C.3.4.17.23	e.c.3.4.17.23	UH
cord-307860-iqk1yiw4	287	5	;	;	:
cord-307860-iqk1yiw4	287	6	UniProtKB	uniprotkb	CD
cord-307860-iqk1yiw4	287	7	Q9BYF1	Q9BYF1	NNS
cord-307860-iqk1yiw4	287	8	)	)	-RRB-
cord-307860-iqk1yiw4	287	9	is	be	VBZ
cord-307860-iqk1yiw4	287	10	a	a	DT
cord-307860-iqk1yiw4	287	11	homodimer	homodimer	JJ
cord-307860-iqk1yiw4	287	12	that	that	WDT
cord-307860-iqk1yiw4	287	13	catalyzes	catalyze	VBZ
cord-307860-iqk1yiw4	287	14	the	the	DT
cord-307860-iqk1yiw4	287	15	reaction	reaction	NN
cord-307860-iqk1yiw4	287	16	:	:	:
cord-307860-iqk1yiw4	287	17	angiotensin	angiotensin	NNP
cord-307860-iqk1yiw4	287	18	II	II	NNP
cord-307860-iqk1yiw4	287	19	+	+	CC
cord-307860-iqk1yiw4	287	20	H	h	NN
cord-307860-iqk1yiw4	287	21	2	2	CD
cord-307860-iqk1yiw4	288	1	O	o	UH
cord-307860-iqk1yiw4	288	2	=	=	SYM
cord-307860-iqk1yiw4	288	3	angiotensin-(1	angiotensin-(1	CD
cord-307860-iqk1yiw4	288	4	-	-	SYM
cord-307860-iqk1yiw4	288	5	7	7	CD
cord-307860-iqk1yiw4	288	6	)	)	-RRB-
cord-307860-iqk1yiw4	288	7	+	+	CC
cord-307860-iqk1yiw4	288	8	L	l	NN
cord-307860-iqk1yiw4	288	9	-	-	HYPH
cord-307860-iqk1yiw4	288	10	phenylalanine	phenylalanine	NN
cord-307860-iqk1yiw4	288	11	[	[	-LRB-
cord-307860-iqk1yiw4	288	12	39	39	CD
cord-307860-iqk1yiw4	288	13	,	,	,
cord-307860-iqk1yiw4	288	14	110	110	CD
cord-307860-iqk1yiw4	288	15	]	]	-RRB-
cord-307860-iqk1yiw4	288	16	.	.	.
cord-307860-iqk1yiw4	289	1	The	the	DT
cord-307860-iqk1yiw4	289	2	human	human	JJ
cord-307860-iqk1yiw4	289	3	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	289	4	gene	gene	NN
cord-307860-iqk1yiw4	289	5	is	be	VBZ
cord-307860-iqk1yiw4	289	6	expressed	express	VBN
cord-307860-iqk1yiw4	289	7	in	in	IN
cord-307860-iqk1yiw4	289	8	a	a	DT
cord-307860-iqk1yiw4	289	9	large	large	JJ
cord-307860-iqk1yiw4	289	10	panel	panel	NN
cord-307860-iqk1yiw4	289	11	of	of	IN
cord-307860-iqk1yiw4	289	12	organs	organ	NNS
cord-307860-iqk1yiw4	289	13	-	-	:
cord-307860-iqk1yiw4	289	14	lungs	lung	NNS
cord-307860-iqk1yiw4	289	15	(	(	-LRB-
cord-307860-iqk1yiw4	289	16	type	type	NN
cord-307860-iqk1yiw4	289	17	II	II	NNP
cord-307860-iqk1yiw4	289	18	pneumocytes	pneumocytes	NNPS
cord-307860-iqk1yiw4	289	19	)	)	-RRB-
cord-307860-iqk1yiw4	289	20	,	,	,
cord-307860-iqk1yiw4	289	21	heart	heart	NN
cord-307860-iqk1yiw4	289	22	,	,	,
cord-307860-iqk1yiw4	289	23	kidney	kidney	NN
cord-307860-iqk1yiw4	289	24	,	,	,
cord-307860-iqk1yiw4	289	25	intestine	intestine	NN
cord-307860-iqk1yiw4	289	26	,	,	,
cord-307860-iqk1yiw4	289	27	cerebral	cerebral	JJ
cord-307860-iqk1yiw4	289	28	neurons	neuron	NNS
cord-307860-iqk1yiw4	289	29	-	-	:
cord-307860-iqk1yiw4	289	30	or	or	CC
cord-307860-iqk1yiw4	289	31	immune	immune	JJ
cord-307860-iqk1yiw4	289	32	cells	cell	NNS
cord-307860-iqk1yiw4	289	33	-	-	HYPH
cord-307860-iqk1yiw4	289	34	alveolar	alveolar	NN
cord-307860-iqk1yiw4	289	35	monocytes	monocyte	NNS
cord-307860-iqk1yiw4	289	36	/	/	SYM
cord-307860-iqk1yiw4	289	37	macrophages	macrophage	NNS
cord-307860-iqk1yiw4	289	38	.	.	.
cord-307860-iqk1yiw4	290	1	The	the	DT
cord-307860-iqk1yiw4	290	2	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	290	3	expression	expression	NN
cord-307860-iqk1yiw4	290	4	is	be	VBZ
cord-307860-iqk1yiw4	290	5	up	up	RB
cord-307860-iqk1yiw4	290	6	-	-	HYPH
cord-307860-iqk1yiw4	290	7	regulated	regulate	VBN
cord-307860-iqk1yiw4	290	8	by	by	IN
cord-307860-iqk1yiw4	290	9	interferon	interferon	NN
cord-307860-iqk1yiw4	290	10	and	and	CC
cord-307860-iqk1yiw4	290	11	influenza	influenza	NN
cord-307860-iqk1yiw4	290	12	A	a	DT
cord-307860-iqk1yiw4	290	13	virus	virus	NN
cord-307860-iqk1yiw4	290	14	in	in	IN
cord-307860-iqk1yiw4	290	15	human	human	JJ
cord-307860-iqk1yiw4	290	16	nasal	nasal	NN
cord-307860-iqk1yiw4	290	17	epithelia	epithelium	NNS
cord-307860-iqk1yiw4	290	18	and	and	CC
cord-307860-iqk1yiw4	290	19	lung	lung	NN
cord-307860-iqk1yiw4	290	20	cells	cell	NNS
cord-307860-iqk1yiw4	290	21	[	[	-LRB-
cord-307860-iqk1yiw4	290	22	111	111	CD
cord-307860-iqk1yiw4	290	23	,	,	,
cord-307860-iqk1yiw4	290	24	112	112	CD
cord-307860-iqk1yiw4	290	25	]	]	-RRB-
cord-307860-iqk1yiw4	290	26	.	.	.
cord-307860-iqk1yiw4	291	1	Shang	Shang	NNP
cord-307860-iqk1yiw4	291	2	et	et	NNP
cord-307860-iqk1yiw4	291	3	al	al	NNP
cord-307860-iqk1yiw4	291	4	.	.	.
cord-307860-iqk1yiw4	292	1	recently	recently	RB
cord-307860-iqk1yiw4	292	2	published	publish	VBD
cord-307860-iqk1yiw4	292	3	the	the	DT
cord-307860-iqk1yiw4	292	4	structure	structure	NN
cord-307860-iqk1yiw4	292	5	of	of	IN
cord-307860-iqk1yiw4	292	6	the	the	DT
cord-307860-iqk1yiw4	292	7	complex	complex	JJ
cord-307860-iqk1yiw4	292	8	SARS	SARS	NNP
cord-307860-iqk1yiw4	292	9	-	-	HYPH
cord-307860-iqk1yiw4	292	10	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	292	11	RBD	RBD	NNP
cord-307860-iqk1yiw4	292	12	/	/	SYM
cord-307860-iqk1yiw4	292	13	human	human	JJ
cord-307860-iqk1yiw4	292	14	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	292	15	(	(	-LRB-
cord-307860-iqk1yiw4	292	16	PDB	PDB	NNP
cord-307860-iqk1yiw4	292	17	ID	ID	NNP
cord-307860-iqk1yiw4	292	18	6VW1	6vw1	CD
cord-307860-iqk1yiw4	292	19	)	)	-RRB-
cord-307860-iqk1yiw4	292	20	.	.	.
cord-307860-iqk1yiw4	293	1	A	a	DT
cord-307860-iqk1yiw4	293	2	comparison	comparison	NN
cord-307860-iqk1yiw4	293	3	with	with	IN
cord-307860-iqk1yiw4	293	4	the	the	DT
cord-307860-iqk1yiw4	293	5	SARS	SARS	NNP
cord-307860-iqk1yiw4	293	6	-	-	HYPH
cord-307860-iqk1yiw4	293	7	CoV	CoV	NNP
cord-307860-iqk1yiw4	293	8	highlighted	highlight	VBD
cord-307860-iqk1yiw4	293	9	that	that	IN
cord-307860-iqk1yiw4	293	10	SARS	SARS	NNP
cord-307860-iqk1yiw4	293	11	-	-	HYPH
cord-307860-iqk1yiw4	293	12	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	293	13	RBM	RBM	NNP
cord-307860-iqk1yiw4	293	14	forms	form	NNS
cord-307860-iqk1yiw4	293	15	larger	large	JJR
cord-307860-iqk1yiw4	293	16	binding	bind	VBG
cord-307860-iqk1yiw4	293	17	interface	interface	NN
cord-307860-iqk1yiw4	293	18	and	and	CC
cord-307860-iqk1yiw4	293	19	more	more	JJR
cord-307860-iqk1yiw4	293	20	contacts	contact	NNS
cord-307860-iqk1yiw4	293	21	with	with	IN
cord-307860-iqk1yiw4	293	22	human	human	JJ
cord-307860-iqk1yiw4	293	23	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	293	24	.	.	.
cord-307860-iqk1yiw4	294	1	The	the	DT
cord-307860-iqk1yiw4	294	2	authors	author	NNS
cord-307860-iqk1yiw4	294	3	focused	focus	VBD
cord-307860-iqk1yiw4	294	4	on	on	IN
cord-307860-iqk1yiw4	294	5	the	the	DT
cord-307860-iqk1yiw4	294	6	receptor	receptor	NN
cord-307860-iqk1yiw4	294	7	-	-	HYPH
cord-307860-iqk1yiw4	294	8	binding	bind	VBG
cord-307860-iqk1yiw4	294	9	motif	motif	NN
cord-307860-iqk1yiw4	294	10	(	(	-LRB-
cord-307860-iqk1yiw4	294	11	RBM	RBM	NNP
cord-307860-iqk1yiw4	294	12	)	)	-RRB-
cord-307860-iqk1yiw4	294	13	of	of	IN
cord-307860-iqk1yiw4	294	14	the	the	DT
cord-307860-iqk1yiw4	294	15	viral	viral	JJ
cord-307860-iqk1yiw4	294	16	RBD	RBD	NNP
cord-307860-iqk1yiw4	294	17	(	(	-LRB-
cord-307860-iqk1yiw4	294	18	S1	S1	NNP
cord-307860-iqk1yiw4	294	19	subunit	subunit	NN
cord-307860-iqk1yiw4	294	20	)	)	-RRB-
cord-307860-iqk1yiw4	294	21	and	and	CC
cord-307860-iqk1yiw4	294	22	the	the	DT
cord-307860-iqk1yiw4	294	23	two	two	CD
cord-307860-iqk1yiw4	294	24	virus	virus	NN
cord-307860-iqk1yiw4	294	25	-	-	HYPH
cord-307860-iqk1yiw4	294	26	binding	bind	VBG
cord-307860-iqk1yiw4	294	27	hotspots-31	hotspots-31	''
cord-307860-iqk1yiw4	294	28	and	and	CC
cord-307860-iqk1yiw4	294	29	353-of	353-of	CD
cord-307860-iqk1yiw4	294	30	the	the	DT
cord-307860-iqk1yiw4	294	31	human	human	JJ
cord-307860-iqk1yiw4	294	32	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	294	33	that	that	WDT
cord-307860-iqk1yiw4	294	34	are	be	VBP
cord-307860-iqk1yiw4	294	35	stabilized	stabilize	VBN
cord-307860-iqk1yiw4	294	36	by	by	IN
cord-307860-iqk1yiw4	294	37	the	the	DT
cord-307860-iqk1yiw4	294	38	viral	viral	JJ
cord-307860-iqk1yiw4	294	39	residues	residue	NNS
cord-307860-iqk1yiw4	294	40	Q493	q493	UH
cord-307860-iqk1yiw4	294	41	and	and	CC
cord-307860-iqk1yiw4	294	42	L455	L455	NNP
cord-307860-iqk1yiw4	294	43	and	and	CC
cord-307860-iqk1yiw4	294	44	N501	N501	NNP
cord-307860-iqk1yiw4	294	45	,	,	,
cord-307860-iqk1yiw4	294	46	respectively	respectively	RB
cord-307860-iqk1yiw4	294	47	.	.	.
cord-307860-iqk1yiw4	295	1	The	the	DT
cord-307860-iqk1yiw4	295	2	study	study	NN
cord-307860-iqk1yiw4	295	3	successfully	successfully	RB
cord-307860-iqk1yiw4	295	4	determined	determine	VBD
cord-307860-iqk1yiw4	295	5	that	that	IN
cord-307860-iqk1yiw4	295	6	the	the	DT
cord-307860-iqk1yiw4	295	7	tight	tight	JJ
cord-307860-iqk1yiw4	295	8	SARS	SARS	NNP
cord-307860-iqk1yiw4	295	9	-	-	HYPH
cord-307860-iqk1yiw4	295	10	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	295	11	binding	bind	VBG
cord-307860-iqk1yiw4	295	12	onto	onto	IN
cord-307860-iqk1yiw4	295	13	the	the	DT
cord-307860-iqk1yiw4	295	14	human	human	JJ
cord-307860-iqk1yiw4	295	15	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	295	16	due	due	IN
cord-307860-iqk1yiw4	295	17	to	to	IN
cord-307860-iqk1yiw4	295	18	a	a	DT
cord-307860-iqk1yiw4	295	19	four	four	CD
cord-307860-iqk1yiw4	295	20	residue	residue	NN
cord-307860-iqk1yiw4	295	21	motif	motif	NN
cord-307860-iqk1yiw4	295	22	482	482	CD
cord-307860-iqk1yiw4	295	23	GVEG	GVEG	NNP
cord-307860-iqk1yiw4	295	24	485	485	CD
cord-307860-iqk1yiw4	295	25	and	and	CC
cord-307860-iqk1yiw4	295	26	to	to	IN
cord-307860-iqk1yiw4	295	27	the	the	DT
cord-307860-iqk1yiw4	295	28	mutation	mutation	NN
cord-307860-iqk1yiw4	295	29	L486F	L486F	NNP
cord-307860-iqk1yiw4	295	30	in	in	IN
cord-307860-iqk1yiw4	295	31	the	the	DT
cord-307860-iqk1yiw4	295	32	RBM	RBM	NNP
cord-307860-iqk1yiw4	295	33	sequence	sequence	NN
cord-307860-iqk1yiw4	295	34	[	[	-LRB-
cord-307860-iqk1yiw4	295	35	101	101	CD
cord-307860-iqk1yiw4	295	36	]	]	-RRB-
cord-307860-iqk1yiw4	295	37	.	.	.
cord-307860-iqk1yiw4	296	1	Yan	Yan	NNP
cord-307860-iqk1yiw4	296	2	et	et	NNP
cord-307860-iqk1yiw4	296	3	al	al	NNP
cord-307860-iqk1yiw4	296	4	.	.	NNP
cord-307860-iqk1yiw4	296	5	have	have	VBP
cord-307860-iqk1yiw4	296	6	recently	recently	RB
cord-307860-iqk1yiw4	296	7	published	publish	VBN
cord-307860-iqk1yiw4	296	8	the	the	DT
cord-307860-iqk1yiw4	296	9	cryo	cryo	NN
cord-307860-iqk1yiw4	296	10	-	-	HYPH
cord-307860-iqk1yiw4	296	11	electron	electron	NN
cord-307860-iqk1yiw4	296	12	microscopy	microscopy	NN
cord-307860-iqk1yiw4	296	13	structures	structure	NNS
cord-307860-iqk1yiw4	296	14	of	of	IN
cord-307860-iqk1yiw4	296	15	the	the	DT
cord-307860-iqk1yiw4	296	16	full	full	JJ
cord-307860-iqk1yiw4	296	17	-	-	HYPH
cord-307860-iqk1yiw4	296	18	length	length	NN
cord-307860-iqk1yiw4	296	19	human	human	JJ
cord-307860-iqk1yiw4	296	20	ACE2-B(0)AT1	ACE2-B(0)AT1	NNP
cord-307860-iqk1yiw4	296	21	complex	complex	NN
cord-307860-iqk1yiw4	296	22	and	and	CC
cord-307860-iqk1yiw4	296	23	RBD	RBD	NNP
cord-307860-iqk1yiw4	296	24	-	-	HYPH
cord-307860-iqk1yiw4	296	25	ACE2-B(0)AT1	ACE2-B(0)AT1	NNP
cord-307860-iqk1yiw4	297	1	(	(	-LRB-
cord-307860-iqk1yiw4	297	2	PDB	PDB	NNP
cord-307860-iqk1yiw4	297	3	ID	ID	NNP
cord-307860-iqk1yiw4	297	4	6M17	6m17	CD
cord-307860-iqk1yiw4	297	5	,	,	,
cord-307860-iqk1yiw4	297	6	6M1D	6m1d	CD
cord-307860-iqk1yiw4	297	7	,	,	,
cord-307860-iqk1yiw4	297	8	6M18	6m18	CD
cord-307860-iqk1yiw4	297	9	)	)	-RRB-
cord-307860-iqk1yiw4	297	10	[	[	-LRB-
cord-307860-iqk1yiw4	297	11	39	39	CD
cord-307860-iqk1yiw4	297	12	]	]	-RRB-
cord-307860-iqk1yiw4	297	13	.	.	.
cord-307860-iqk1yiw4	298	1	The	the	DT
cord-307860-iqk1yiw4	298	2	authors	author	NNS
cord-307860-iqk1yiw4	298	3	have	have	VBP
cord-307860-iqk1yiw4	298	4	shown	show	VBN
cord-307860-iqk1yiw4	298	5	that	that	IN
cord-307860-iqk1yiw4	298	6	two	two	CD
cord-307860-iqk1yiw4	298	7	S	s	NN
cord-307860-iqk1yiw4	298	8	glycoprotein	glycoprotein	NN
cord-307860-iqk1yiw4	298	9	trimers	trimer	VBZ
cord-307860-iqk1yiw4	298	10	simultaneously	simultaneously	RB
cord-307860-iqk1yiw4	298	11	bind	bind	VB
cord-307860-iqk1yiw4	298	12	to	to	IN
cord-307860-iqk1yiw4	298	13	an	an	DT
cord-307860-iqk1yiw4	298	14	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	298	15	homodimer	homodimer	NN
cord-307860-iqk1yiw4	298	16	.	.	.
cord-307860-iqk1yiw4	299	1	Moreover	moreover	RB
cord-307860-iqk1yiw4	299	2	,	,	,
cord-307860-iqk1yiw4	299	3	the	the	DT
cord-307860-iqk1yiw4	299	4	authors	author	NNS
cord-307860-iqk1yiw4	299	5	highlighted	highlight	VBD
cord-307860-iqk1yiw4	299	6	some	some	DT
cord-307860-iqk1yiw4	299	7	residues	residue	NNS
cord-307860-iqk1yiw4	299	8	that	that	WDT
cord-307860-iqk1yiw4	299	9	could	could	MD
cord-307860-iqk1yiw4	299	10	explain	explain	VB
cord-307860-iqk1yiw4	299	11	the	the	DT
cord-307860-iqk1yiw4	299	12	difference	difference	NN
cord-307860-iqk1yiw4	299	13	between	between	IN
cord-307860-iqk1yiw4	299	14	the	the	DT
cord-307860-iqk1yiw4	299	15	cell	cell	NN
cord-307860-iqk1yiw4	299	16	entry	entry	NN
cord-307860-iqk1yiw4	299	17	of	of	IN
cord-307860-iqk1yiw4	299	18	SARS	SARS	NNP
cord-307860-iqk1yiw4	299	19	-	-	HYPH
cord-307860-iqk1yiw4	299	20	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	299	21	and	and	CC
cord-307860-iqk1yiw4	299	22	SARS	SARS	NNP
cord-307860-iqk1yiw4	299	23	-	-	HYPH
cord-307860-iqk1yiw4	299	24	CoV.	CoV.	NNP
cord-307860-iqk1yiw4	299	25	Two	two	CD
cord-307860-iqk1yiw4	299	26	mutations	mutation	NNS
cord-307860-iqk1yiw4	299	27	(	(	-LRB-
cord-307860-iqk1yiw4	299	28	Val404	val404	RB
cord-307860-iqk1yiw4	299	29	to	to	IN
cord-307860-iqk1yiw4	299	30	Lys317	lys317	CD
cord-307860-iqk1yiw4	299	31	and	and	CC
cord-307860-iqk1yiw4	299	32	Leu472	leu472	XX
cord-307860-iqk1yiw4	299	33	to	to	IN
cord-307860-iqk1yiw4	299	34	Phe486	phe486	ADD
cord-307860-iqk1yiw4	299	35	)	)	-RRB-
cord-307860-iqk1yiw4	299	36	are	be	VBP
cord-307860-iqk1yiw4	299	37	responsible	responsible	JJ
cord-307860-iqk1yiw4	299	38	for	for	IN
cord-307860-iqk1yiw4	299	39	an	an	DT
cord-307860-iqk1yiw4	299	40	enhancement	enhancement	NN
cord-307860-iqk1yiw4	299	41	interaction	interaction	NN
cord-307860-iqk1yiw4	299	42	of	of	IN
cord-307860-iqk1yiw4	299	43	SARS	SARS	NNP
cord-307860-iqk1yiw4	299	44	-	-	HYPH
cord-307860-iqk1yiw4	299	45	CoV-2-RBD	CoV-2-RBD	NNP
cord-307860-iqk1yiw4	299	46	and	and	CC
cord-307860-iqk1yiw4	299	47	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	299	48	.	.	.
cord-307860-iqk1yiw4	300	1	In	in	IN
cord-307860-iqk1yiw4	300	2	contrast	contrast	NN
cord-307860-iqk1yiw4	300	3	,	,	,
cord-307860-iqk1yiw4	300	4	the	the	DT
cord-307860-iqk1yiw4	300	5	mutation	mutation	NN
cord-307860-iqk1yiw4	300	6	Arg436	arg436	NN
cord-307860-iqk1yiw4	300	7	to	to	IN
cord-307860-iqk1yiw4	300	8	Asn439	asn439	DT
cord-307860-iqk1yiw4	300	9	weakens	weaken	VBZ
cord-307860-iqk1yiw4	300	10	the	the	DT
cord-307860-iqk1yiw4	300	11	SARS	SARS	NNP
cord-307860-iqk1yiw4	300	12	-	-	HYPH
cord-307860-iqk1yiw4	300	13	CoV-2-RBD	CoV-2-RBD	NNP
cord-307860-iqk1yiw4	300	14	and	and	CC
cord-307860-iqk1yiw4	300	15	hACE2	hace2	NN
cord-307860-iqk1yiw4	300	16	interaction	interaction	NN
cord-307860-iqk1yiw4	300	17	[	[	-LRB-
cord-307860-iqk1yiw4	300	18	39	39	CD
cord-307860-iqk1yiw4	300	19	]	]	-RRB-
cord-307860-iqk1yiw4	300	20	.	.	.
cord-307860-iqk1yiw4	301	1	The	the	DT
cord-307860-iqk1yiw4	301	2	sodium	sodium	NN
cord-307860-iqk1yiw4	301	3	-	-	HYPH
cord-307860-iqk1yiw4	301	4	dependent	dependent	JJ
cord-307860-iqk1yiw4	301	5	neutral	neutral	JJ
cord-307860-iqk1yiw4	301	6	amino	amino	NN
cord-307860-iqk1yiw4	301	7	acid	acid	NN
cord-307860-iqk1yiw4	301	8	transporter	transporter	NN
cord-307860-iqk1yiw4	301	9	B(0)AT1	B(0)AT1	NNP
cord-307860-iqk1yiw4	301	10	Fig	Fig	NNP
cord-307860-iqk1yiw4	301	11	.	.	.
cord-307860-iqk1yiw4	302	1	6	6	CD
cord-307860-iqk1yiw4	303	1	The	the	DT
cord-307860-iqk1yiw4	303	2	multiple	multiple	JJ
cord-307860-iqk1yiw4	303	3	sequence	sequence	NN
cord-307860-iqk1yiw4	303	4	alignment	alignment	NN
cord-307860-iqk1yiw4	303	5	of	of	IN
cord-307860-iqk1yiw4	303	6	spike	spike	NN
cord-307860-iqk1yiw4	303	7	(	(	-LRB-
cord-307860-iqk1yiw4	303	8	S	s	NN
cord-307860-iqk1yiw4	303	9	)	)	-RRB-
cord-307860-iqk1yiw4	303	10	S1	S1	NNP
cord-307860-iqk1yiw4	303	11	/	/	SYM
cord-307860-iqk1yiw4	303	12	S2	S2	NNP
cord-307860-iqk1yiw4	303	13	cleavage	cleavage	NN
cord-307860-iqk1yiw4	303	14	site	site	NN
cord-307860-iqk1yiw4	303	15	sequences	sequence	NNS
cord-307860-iqk1yiw4	303	16	using	use	VBG
cord-307860-iqk1yiw4	303	17	the	the	DT
cord-307860-iqk1yiw4	303	18	Clustal	Clustal	NNP
cord-307860-iqk1yiw4	303	19	Omega	Omega	NNP
cord-307860-iqk1yiw4	303	20	program	program	NN
cord-307860-iqk1yiw4	303	21	.	.	.
cord-307860-iqk1yiw4	304	1	The	the	DT
cord-307860-iqk1yiw4	304	2	S1	S1	NNP
cord-307860-iqk1yiw4	304	3	/	/	SYM
cord-307860-iqk1yiw4	304	4	S2	s2	NN
cord-307860-iqk1yiw4	304	5	sequences	sequence	NNS
cord-307860-iqk1yiw4	304	6	are	be	VBP
cord-307860-iqk1yiw4	304	7	bolded	bolde	VBN
cord-307860-iqk1yiw4	304	8	and	and	CC
cord-307860-iqk1yiw4	304	9	the	the	DT
cord-307860-iqk1yiw4	304	10	basic	basic	JJ
cord-307860-iqk1yiw4	304	11	arginine	arginine	NN
cord-307860-iqk1yiw4	304	12	and	and	CC
cord-307860-iqk1yiw4	304	13	lysine	lysine	NN
cord-307860-iqk1yiw4	304	14	residues	residue	NNS
cord-307860-iqk1yiw4	304	15	are	be	VBP
cord-307860-iqk1yiw4	304	16	marked	mark	VBN
cord-307860-iqk1yiw4	304	17	in	in	IN
cord-307860-iqk1yiw4	304	18	red	red	JJ
cord-307860-iqk1yiw4	304	19	[	[	-LRB-
cord-307860-iqk1yiw4	304	20	93	93	CD
cord-307860-iqk1yiw4	304	21	]	]	-RRB-
cord-307860-iqk1yiw4	304	22	(	(	-LRB-
cord-307860-iqk1yiw4	304	23	SLC6A19	SLC6A19	NFP
cord-307860-iqk1yiw4	304	24	)	)	-RRB-
cord-307860-iqk1yiw4	304	25	(	(	-LRB-
cord-307860-iqk1yiw4	304	26	UniProtKB	UniProtKB	``
cord-307860-iqk1yiw4	304	27	Q695T7	Q695T7	NNP
cord-307860-iqk1yiw4	304	28	)	)	-RRB-
cord-307860-iqk1yiw4	304	29	mediates	mediate	VBZ
cord-307860-iqk1yiw4	304	30	absorption	absorption	NN
cord-307860-iqk1yiw4	304	31	of	of	IN
cord-307860-iqk1yiw4	304	32	neutral	neutral	JJ
cord-307860-iqk1yiw4	304	33	amino	amino	NN
cord-307860-iqk1yiw4	304	34	acids	acid	NNS
cord-307860-iqk1yiw4	304	35	across	across	IN
cord-307860-iqk1yiw4	304	36	the	the	DT
cord-307860-iqk1yiw4	304	37	membrane	membrane	NN
cord-307860-iqk1yiw4	304	38	of	of	IN
cord-307860-iqk1yiw4	304	39	the	the	DT
cord-307860-iqk1yiw4	304	40	renal	renal	JJ
cord-307860-iqk1yiw4	304	41	and	and	CC
cord-307860-iqk1yiw4	304	42	intestinal	intestinal	JJ
cord-307860-iqk1yiw4	304	43	epithelial	epithelial	JJ
cord-307860-iqk1yiw4	304	44	cells	cell	NNS
cord-307860-iqk1yiw4	304	45	and	and	CC
cord-307860-iqk1yiw4	304	46	mutations	mutation	NNS
cord-307860-iqk1yiw4	304	47	in	in	IN
cord-307860-iqk1yiw4	304	48	B(0)AT1	B(0)AT1	NNP
cord-307860-iqk1yiw4	304	49	(	(	-LRB-
cord-307860-iqk1yiw4	304	50	such	such	JJ
cord-307860-iqk1yiw4	304	51	as	as	IN
cord-307860-iqk1yiw4	304	52	A69	A69	NNP
cord-307860-iqk1yiw4	304	53	T	T	NNP
cord-307860-iqk1yiw4	304	54	and	and	CC
cord-307860-iqk1yiw4	304	55	R240Q	R240Q	NNP
cord-307860-iqk1yiw4	304	56	)	)	-RRB-
cord-307860-iqk1yiw4	304	57	may	may	MD
cord-307860-iqk1yiw4	304	58	cause	cause	VB
cord-307860-iqk1yiw4	304	59	Harnup	Harnup	NNP
cord-307860-iqk1yiw4	304	60	disorder	disorder	NN
cord-307860-iqk1yiw4	304	61	[	[	-LRB-
cord-307860-iqk1yiw4	304	62	113	113	CD
cord-307860-iqk1yiw4	304	63	]	]	-RRB-
cord-307860-iqk1yiw4	304	64	[	[	-LRB-
cord-307860-iqk1yiw4	304	65	114	114	CD
cord-307860-iqk1yiw4	304	66	]	]	-RRB-
cord-307860-iqk1yiw4	304	67	[	[	-LRB-
cord-307860-iqk1yiw4	304	68	115	115	CD
cord-307860-iqk1yiw4	304	69	]	]	-RRB-
cord-307860-iqk1yiw4	304	70	[	[	-LRB-
cord-307860-iqk1yiw4	304	71	116	116	CD
cord-307860-iqk1yiw4	304	72	]	]	-RRB-
cord-307860-iqk1yiw4	304	73	.	.	.
cord-307860-iqk1yiw4	305	1	The	the	DT
cord-307860-iqk1yiw4	305	2	B(0)AT1	b(0)at1	JJ
cord-307860-iqk1yiw4	305	3	expression	expression	NN
cord-307860-iqk1yiw4	305	4	onto	onto	IN
cord-307860-iqk1yiw4	305	5	the	the	DT
cord-307860-iqk1yiw4	305	6	small	small	JJ
cord-307860-iqk1yiw4	305	7	intestinal	intestinal	JJ
cord-307860-iqk1yiw4	305	8	cells	cell	NNS
cord-307860-iqk1yiw4	305	9	depends	depend	VBZ
cord-307860-iqk1yiw4	305	10	on	on	IN
cord-307860-iqk1yiw4	305	11	the	the	DT
cord-307860-iqk1yiw4	305	12	co	co	NN
cord-307860-iqk1yiw4	305	13	-	-	NN
cord-307860-iqk1yiw4	305	14	expression	expression	NN
cord-307860-iqk1yiw4	305	15	of	of	IN
cord-307860-iqk1yiw4	305	16	the	the	DT
cord-307860-iqk1yiw4	305	17	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	305	18	and	and	CC
cord-307860-iqk1yiw4	305	19	is	be	VBZ
cord-307860-iqk1yiw4	305	20	enhanced	enhance	VBN
cord-307860-iqk1yiw4	305	21	by	by	IN
cord-307860-iqk1yiw4	305	22	aminopeptidase	aminopeptidase	NN
cord-307860-iqk1yiw4	305	23	N	N	NNP
cord-307860-iqk1yiw4	305	24	(	(	-LRB-
cord-307860-iqk1yiw4	305	25	CD13	CD13	NNP
cord-307860-iqk1yiw4	305	26	)	)	-RRB-
cord-307860-iqk1yiw4	305	27	[	[	-LRB-
cord-307860-iqk1yiw4	305	28	117	117	CD
cord-307860-iqk1yiw4	305	29	]	]	-RRB-
cord-307860-iqk1yiw4	305	30	.	.	.
cord-307860-iqk1yiw4	306	1	The	the	DT
cord-307860-iqk1yiw4	306	2	aminopeptidase	aminopeptidase	NN
cord-307860-iqk1yiw4	306	3	N	n	CD
cord-307860-iqk1yiw4	306	4	(	(	-LRB-
cord-307860-iqk1yiw4	306	5	E.C.	E.C.	NNP
cord-307860-iqk1yiw4	306	6	3.4.11.2	3.4.11.2	CD
cord-307860-iqk1yiw4	306	7	;	;	:
cord-307860-iqk1yiw4	306	8	UniProt	UniProt	NNP
cord-307860-iqk1yiw4	306	9	UK	UK	NNP
cord-307860-iqk1yiw4	306	10	P15114	P15114	NNP
cord-307860-iqk1yiw4	306	11	)	)	-RRB-
cord-307860-iqk1yiw4	306	12	mediates	mediate	VBZ
cord-307860-iqk1yiw4	306	13	other	other	JJ
cord-307860-iqk1yiw4	306	14	viral	viral	JJ
cord-307860-iqk1yiw4	306	15	infections	infection	NNS
cord-307860-iqk1yiw4	306	16	-	-	HYPH
cord-307860-iqk1yiw4	306	17	transmissible	transmissible	JJ
cord-307860-iqk1yiw4	306	18	gastroenteritis	gastroenteritis	NN
cord-307860-iqk1yiw4	306	19	virus	virus	NN
cord-307860-iqk1yiw4	306	20	responsible	responsible	JJ
cord-307860-iqk1yiw4	306	21	for	for	IN
cord-307860-iqk1yiw4	306	22	diarrheal	diarrheal	JJ
cord-307860-iqk1yiw4	306	23	disease	disease	NN
cord-307860-iqk1yiw4	306	24	in	in	IN
cord-307860-iqk1yiw4	306	25	piglets	piglet	NNS
cord-307860-iqk1yiw4	306	26	,	,	,
cord-307860-iqk1yiw4	306	27	cytomegalovirus	cytomegalovirus	NN
cord-307860-iqk1yiw4	306	28	or	or	CC
cord-307860-iqk1yiw4	306	29	human	human	JJ
cord-307860-iqk1yiw4	306	30	CoV-229E	CoV-229E	NNPS
cord-307860-iqk1yiw4	306	31	[	[	-LRB-
cord-307860-iqk1yiw4	306	32	118	118	CD
cord-307860-iqk1yiw4	306	33	]	]	-RRB-
cord-307860-iqk1yiw4	306	34	[	[	-LRB-
cord-307860-iqk1yiw4	306	35	119	119	CD
cord-307860-iqk1yiw4	306	36	]	]	-RRB-
cord-307860-iqk1yiw4	306	37	[	[	-LRB-
cord-307860-iqk1yiw4	306	38	120	120	CD
cord-307860-iqk1yiw4	306	39	]	]	-RRB-
cord-307860-iqk1yiw4	306	40	.	.	.
cord-307860-iqk1yiw4	307	1	Lan	Lan	NNP
cord-307860-iqk1yiw4	307	2	J.	J.	NNP
cord-307860-iqk1yiw4	307	3	et	et	NNP
cord-307860-iqk1yiw4	307	4	al	al	NNP
cord-307860-iqk1yiw4	307	5	.	.	.
cord-307860-iqk1yiw4	308	1	compared	compare	VBN
cord-307860-iqk1yiw4	308	2	the	the	DT
cord-307860-iqk1yiw4	308	3	SARS	SARS	NNP
cord-307860-iqk1yiw4	308	4	-	-	HYPH
cord-307860-iqk1yiw4	308	5	CoV	CoV	NNP
cord-307860-iqk1yiw4	308	6	and	and	CC
cord-307860-iqk1yiw4	308	7	SARS	SARS	NNP
cord-307860-iqk1yiw4	308	8	-	-	HYPH
cord-307860-iqk1yiw4	308	9	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	308	10	RBD	RBD	NNP
cord-307860-iqk1yiw4	308	11	bound	bind	VBN
cord-307860-iqk1yiw4	308	12	to	to	IN
cord-307860-iqk1yiw4	308	13	hACE2	hace2	ADD
cord-307860-iqk1yiw4	308	14	and	and	CC
cord-307860-iqk1yiw4	308	15	suggested	suggest	VBD
cord-307860-iqk1yiw4	308	16	a	a	DT
cord-307860-iqk1yiw4	308	17	convergent	convergent	JJ
cord-307860-iqk1yiw4	308	18	evolution	evolution	NN
cord-307860-iqk1yiw4	308	19	between	between	IN
cord-307860-iqk1yiw4	308	20	the	the	DT
cord-307860-iqk1yiw4	308	21	two	two	CD
cord-307860-iqk1yiw4	308	22	coronaviruses	coronaviruse	NNS
cord-307860-iqk1yiw4	308	23	.	.	.
cord-307860-iqk1yiw4	309	1	They	-PRON-	PRP
cord-307860-iqk1yiw4	309	2	further	further	RB
cord-307860-iqk1yiw4	309	3	suggest	suggest	VBP
cord-307860-iqk1yiw4	309	4	that	that	IN
cord-307860-iqk1yiw4	309	5	a	a	DT
cord-307860-iqk1yiw4	309	6	unique	unique	JJ
cord-307860-iqk1yiw4	309	7	"	"	``
cord-307860-iqk1yiw4	309	8	RRAR	RRAR	NNP
cord-307860-iqk1yiw4	309	9	"	"	''
cord-307860-iqk1yiw4	309	10	cleavage	cleavage	NN
cord-307860-iqk1yiw4	309	11	site	site	NN
cord-307860-iqk1yiw4	309	12	at	at	IN
cord-307860-iqk1yiw4	309	13	the	the	DT
cord-307860-iqk1yiw4	309	14	S1	S1	NNP
cord-307860-iqk1yiw4	309	15	/	/	SYM
cord-307860-iqk1yiw4	309	16	S2	S2	NNP
cord-307860-iqk1yiw4	309	17	boundary	boundary	NN
cord-307860-iqk1yiw4	309	18	of	of	IN
cord-307860-iqk1yiw4	309	19	the	the	DT
cord-307860-iqk1yiw4	309	20	SARS	SARS	NNP
cord-307860-iqk1yiw4	310	1	-Cov-2	-Cov-2	:
cord-307860-iqk1yiw4	310	2	has	have	VBZ
cord-307860-iqk1yiw4	310	3	a	a	DT
cord-307860-iqk1yiw4	310	4	crucial	crucial	JJ
cord-307860-iqk1yiw4	310	5	role	role	NN
cord-307860-iqk1yiw4	310	6	in	in	IN
cord-307860-iqk1yiw4	310	7	rapid	rapid	JJ
cord-307860-iqk1yiw4	310	8	inter	inter	JJ
cord-307860-iqk1yiw4	310	9	-	-	JJ
cord-307860-iqk1yiw4	310	10	human	human	JJ
cord-307860-iqk1yiw4	310	11	transmission	transmission	NN
cord-307860-iqk1yiw4	311	1	(	(	-LRB-
cord-307860-iqk1yiw4	311	2	PDB	PDB	NNP
cord-307860-iqk1yiw4	311	3	ID	ID	NNP
cord-307860-iqk1yiw4	311	4	6M0J	6m0j	CD
cord-307860-iqk1yiw4	311	5	)	)	-RRB-
cord-307860-iqk1yiw4	311	6	.	.	.
cord-307860-iqk1yiw4	312	1	The	the	DT
cord-307860-iqk1yiw4	312	2	authors	author	NNS
cord-307860-iqk1yiw4	312	3	emphasize	emphasize	VBP
cord-307860-iqk1yiw4	312	4	the	the	DT
cord-307860-iqk1yiw4	312	5	importance	importance	NN
cord-307860-iqk1yiw4	312	6	of	of	IN
cord-307860-iqk1yiw4	312	7	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	312	8	antibodies	antibody	NNS
cord-307860-iqk1yiw4	312	9	in	in	IN
cord-307860-iqk1yiw4	312	10	the	the	DT
cord-307860-iqk1yiw4	312	11	evolution	evolution	NN
cord-307860-iqk1yiw4	312	12	of	of	IN
cord-307860-iqk1yiw4	312	13	SARS	SARS	NNP
cord-307860-iqk1yiw4	312	14	-	-	HYPH
cord-307860-iqk1yiw4	312	15	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	312	16	infection	infection	NN
cord-307860-iqk1yiw4	312	17	.	.	.
cord-307860-iqk1yiw4	313	1	Their	-PRON-	PRP$
cord-307860-iqk1yiw4	313	2	structural	structural	JJ
cord-307860-iqk1yiw4	313	3	study	study	NN
cord-307860-iqk1yiw4	313	4	suggests	suggest	VBZ
cord-307860-iqk1yiw4	313	5	that	that	IN
cord-307860-iqk1yiw4	313	6	the	the	DT
cord-307860-iqk1yiw4	313	7	lack	lack	NN
cord-307860-iqk1yiw4	313	8	of	of	IN
cord-307860-iqk1yiw4	313	9	cross	cross	NN
cord-307860-iqk1yiw4	313	10	-	-	NN
cord-307860-iqk1yiw4	313	11	reactivity	reactivity	NN
cord-307860-iqk1yiw4	313	12	by	by	IN
cord-307860-iqk1yiw4	313	13	m396	m396	NNP
cord-307860-iqk1yiw4	313	14	and	and	CC
cord-307860-iqk1yiw4	313	15	80R	80r	JJ
cord-307860-iqk1yiw4	313	16	antibodies	antibody	NNS
cord-307860-iqk1yiw4	313	17	that	that	WDT
cord-307860-iqk1yiw4	313	18	neutralizes	neutralize	VBZ
cord-307860-iqk1yiw4	313	19	SARS	SARS	NNP
cord-307860-iqk1yiw4	313	20	-	-	HYPH
cord-307860-iqk1yiw4	313	21	CoV	CoV	NNP
cord-307860-iqk1yiw4	313	22	resides	reside	VBZ
cord-307860-iqk1yiw4	313	23	in	in	IN
cord-307860-iqk1yiw4	313	24	several	several	JJ
cord-307860-iqk1yiw4	313	25	residue	residue	NN
cord-307860-iqk1yiw4	313	26	changes	change	NNS
cord-307860-iqk1yiw4	313	27	in	in	IN
cord-307860-iqk1yiw4	313	28	the	the	DT
cord-307860-iqk1yiw4	313	29	SARS	SARS	NNP
cord-307860-iqk1yiw4	313	30	-	-	HYPH
cord-307860-iqk1yiw4	313	31	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	313	32	RBD	RBD	NNP
cord-307860-iqk1yiw4	313	33	[	[	-LRB-
cord-307860-iqk1yiw4	313	34	121	121	CD
cord-307860-iqk1yiw4	313	35	]	]	-RRB-
cord-307860-iqk1yiw4	313	36	.	.	.
cord-307860-iqk1yiw4	314	1	Wang	Wang	NNP
cord-307860-iqk1yiw4	314	2	et	et	NNP
cord-307860-iqk1yiw4	314	3	al	al	NNP
cord-307860-iqk1yiw4	314	4	.	.	.
cord-307860-iqk1yiw4	315	1	firstly	firstly	RB
cord-307860-iqk1yiw4	315	2	identify	identify	VB
cord-307860-iqk1yiw4	315	3	that	that	IN
cord-307860-iqk1yiw4	315	4	S1	S1	NNP
cord-307860-iqk1yiw4	315	5	C	c	NN
cord-307860-iqk1yiw4	315	6	-	-	HYPH
cord-307860-iqk1yiw4	315	7	terminal	terminal	NN
cord-307860-iqk1yiw4	315	8	domain	domain	NN
cord-307860-iqk1yiw4	315	9	(	(	-LRB-
cord-307860-iqk1yiw4	315	10	SARS	SARS	NNP
cord-307860-iqk1yiw4	315	11	-	-	HYPH
cord-307860-iqk1yiw4	315	12	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	315	13	S	S	NNP
cord-307860-iqk1yiw4	315	14	-	-	HYPH
cord-307860-iqk1yiw4	315	15	CTD	CTD	NNP
cord-307860-iqk1yiw4	315	16	)	)	-RRB-
cord-307860-iqk1yiw4	315	17	is	be	VBZ
cord-307860-iqk1yiw4	315	18	the	the	DT
cord-307860-iqk1yiw4	315	19	key	key	JJ
cord-307860-iqk1yiw4	315	20	region	region	NN
cord-307860-iqk1yiw4	315	21	that	that	WDT
cord-307860-iqk1yiw4	315	22	interacts	interact	VBZ
cord-307860-iqk1yiw4	315	23	with	with	IN
cord-307860-iqk1yiw4	315	24	the	the	DT
cord-307860-iqk1yiw4	315	25	human	human	JJ
cord-307860-iqk1yiw4	315	26	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	315	27	.	.	.
cord-307860-iqk1yiw4	316	1	A	a	DT
cord-307860-iqk1yiw4	316	2	comprehensive	comprehensive	JJ
cord-307860-iqk1yiw4	316	3	comparison	comparison	NN
cord-307860-iqk1yiw4	316	4	between	between	IN
cord-307860-iqk1yiw4	316	5	SARS	SARS	NNP
cord-307860-iqk1yiw4	316	6	-	-	HYPH
cord-307860-iqk1yiw4	316	7	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	316	8	(	(	-LRB-
cord-307860-iqk1yiw4	316	9	PDB	PDB	NNP
cord-307860-iqk1yiw4	316	10	ID	ID	NNP
cord-307860-iqk1yiw4	316	11	6LZG	6lzg	CD
cord-307860-iqk1yiw4	316	12	)	)	-RRB-
cord-307860-iqk1yiw4	316	13	with	with	IN
cord-307860-iqk1yiw4	316	14	similar	similar	JJ
cord-307860-iqk1yiw4	316	15	SARS	SARS	NNP
cord-307860-iqk1yiw4	316	16	-	-	HYPH
cord-307860-iqk1yiw4	316	17	CoV	CoV	NNP
cord-307860-iqk1yiw4	316	18	,	,	,
cord-307860-iqk1yiw4	316	19	reveals	reveal	VBZ
cord-307860-iqk1yiw4	316	20	that	that	IN
cord-307860-iqk1yiw4	316	21	the	the	DT
cord-307860-iqk1yiw4	316	22	former	former	NN
cord-307860-iqk1yiw4	316	23	has	have	VBZ
cord-307860-iqk1yiw4	316	24	a	a	DT
cord-307860-iqk1yiw4	316	25	higher	high	JJR
cord-307860-iqk1yiw4	316	26	affinity	affinity	NN
cord-307860-iqk1yiw4	316	27	for	for	IN
cord-307860-iqk1yiw4	316	28	the	the	DT
cord-307860-iqk1yiw4	316	29	receptor	receptor	NN
cord-307860-iqk1yiw4	316	30	hACE2	hACE2	NNP
cord-307860-iqk1yiw4	316	31	.	.	.
cord-307860-iqk1yiw4	317	1	Moreover	moreover	RB
cord-307860-iqk1yiw4	317	2	,	,	,
cord-307860-iqk1yiw4	317	3	the	the	DT
cord-307860-iqk1yiw4	317	4	authors	author	NNS
cord-307860-iqk1yiw4	317	5	advance	advance	VBP
cord-307860-iqk1yiw4	317	6	the	the	DT
cord-307860-iqk1yiw4	317	7	hypothesis	hypothesis	NN
cord-307860-iqk1yiw4	317	8	of	of	IN
cord-307860-iqk1yiw4	317	9	the	the	DT
cord-307860-iqk1yiw4	317	10	"	"	``
cord-307860-iqk1yiw4	317	11	hotspot	hotspot	NN
cord-307860-iqk1yiw4	317	12	"	"	''
cord-307860-iqk1yiw4	317	13	region	region	NN
cord-307860-iqk1yiw4	317	14	in	in	IN
cord-307860-iqk1yiw4	317	15	S	S	NNP
cord-307860-iqk1yiw4	317	16	for	for	IN
cord-307860-iqk1yiw4	317	17	receptor	receptor	NN
cord-307860-iqk1yiw4	317	18	binding	binding	NN
cord-307860-iqk1yiw4	317	19	.	.	.
cord-307860-iqk1yiw4	318	1	Further	further	JJ
cord-307860-iqk1yiw4	318	2	experiments	experiment	NNS
cord-307860-iqk1yiw4	318	3	with	with	IN
cord-307860-iqk1yiw4	318	4	the	the	DT
cord-307860-iqk1yiw4	318	5	polyclonal	polyclonal	JJ
cord-307860-iqk1yiw4	318	6	antibodies	antibody	NNS
cord-307860-iqk1yiw4	318	7	,	,	,
cord-307860-iqk1yiw4	318	8	confirm	confirm	VBP
cord-307860-iqk1yiw4	318	9	the	the	DT
cord-307860-iqk1yiw4	318	10	differences	difference	NNS
cord-307860-iqk1yiw4	318	11	between	between	IN
cord-307860-iqk1yiw4	318	12	SARS	SARS	NNP
cord-307860-iqk1yiw4	318	13	-	-	HYPH
cord-307860-iqk1yiw4	318	14	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	318	15	and	and	CC
cord-307860-iqk1yiw4	318	16	SARS	SARS	NNP
cord-307860-iqk1yiw4	318	17	-	-	HYPH
cord-307860-iqk1yiw4	318	18	CoV	CoV	NNP
cord-307860-iqk1yiw4	318	19	'	'	''
cord-307860-iqk1yiw4	318	20	S	S	NNP
cord-307860-iqk1yiw4	318	21	glycoprotein	glycoprotein	NN
cord-307860-iqk1yiw4	318	22	[	[	-LRB-
cord-307860-iqk1yiw4	318	23	36	36	CD
cord-307860-iqk1yiw4	318	24	]	]	-RRB-
cord-307860-iqk1yiw4	318	25	.	.	.
cord-307860-iqk1yiw4	319	1	The	the	DT
cord-307860-iqk1yiw4	319	2	COVID-19	covid-19	NN
cord-307860-iqk1yiw4	319	3	is	be	VBZ
cord-307860-iqk1yiw4	319	4	the	the	DT
cord-307860-iqk1yiw4	319	5	disease	disease	NN
cord-307860-iqk1yiw4	319	6	due	due	IN
cord-307860-iqk1yiw4	319	7	to	to	IN
cord-307860-iqk1yiw4	319	8	the	the	DT
cord-307860-iqk1yiw4	319	9	interaction	interaction	NN
cord-307860-iqk1yiw4	319	10	of	of	IN
cord-307860-iqk1yiw4	319	11	the	the	DT
cord-307860-iqk1yiw4	319	12	pathogen	pathogen	NN
cord-307860-iqk1yiw4	319	13	SARS	SARS	NNP
cord-307860-iqk1yiw4	319	14	-	-	HYPH
cord-307860-iqk1yiw4	319	15	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	319	16	with	with	IN
cord-307860-iqk1yiw4	319	17	the	the	DT
cord-307860-iqk1yiw4	319	18	human	human	JJ
cord-307860-iqk1yiw4	319	19	host	host	NN
cord-307860-iqk1yiw4	319	20	.	.	.
cord-307860-iqk1yiw4	320	1	Consequently	consequently	RB
cord-307860-iqk1yiw4	320	2	,	,	,
cord-307860-iqk1yiw4	320	3	all	all	DT
cord-307860-iqk1yiw4	320	4	aspects	aspect	NNS
cord-307860-iqk1yiw4	320	5	of	of	IN
cord-307860-iqk1yiw4	320	6	this	this	DT
cord-307860-iqk1yiw4	320	7	interaction	interaction	NN
cord-307860-iqk1yiw4	320	8	draw	draw	VBP
cord-307860-iqk1yiw4	320	9	the	the	DT
cord-307860-iqk1yiw4	320	10	picture	picture	NN
cord-307860-iqk1yiw4	320	11	of	of	IN
cord-307860-iqk1yiw4	320	12	Fig	Fig	NNP
cord-307860-iqk1yiw4	320	13	.	.	.
cord-307860-iqk1yiw4	321	1	7	7	CD
cord-307860-iqk1yiw4	322	1	The	the	DT
cord-307860-iqk1yiw4	322	2	multiple	multiple	JJ
cord-307860-iqk1yiw4	322	3	sequence	sequence	NN
cord-307860-iqk1yiw4	322	4	alignment	alignment	NN
cord-307860-iqk1yiw4	322	5	of	of	IN
cord-307860-iqk1yiw4	322	6	spike	spike	NN
cord-307860-iqk1yiw4	322	7	(	(	-LRB-
cord-307860-iqk1yiw4	322	8	S	s	NN
cord-307860-iqk1yiw4	322	9	)	)	-RRB-
cord-307860-iqk1yiw4	322	10	S2′	S2′	.
cord-307860-iqk1yiw4	323	1	cleavage	cleavage	NN
cord-307860-iqk1yiw4	323	2	site	site	NN
cord-307860-iqk1yiw4	323	3	sequences	sequence	NNS
cord-307860-iqk1yiw4	323	4	using	use	VBG
cord-307860-iqk1yiw4	323	5	the	the	DT
cord-307860-iqk1yiw4	323	6	Clustal	Clustal	NNP
cord-307860-iqk1yiw4	323	7	Omega	Omega	NNP
cord-307860-iqk1yiw4	323	8	program	program	NN
cord-307860-iqk1yiw4	323	9	.	.	.
cord-307860-iqk1yiw4	324	1	The	the	DT
cord-307860-iqk1yiw4	324	2	S1	S1	NNP
cord-307860-iqk1yiw4	324	3	/	/	SYM
cord-307860-iqk1yiw4	324	4	S2	s2	NN
cord-307860-iqk1yiw4	324	5	sequences	sequence	NNS
cord-307860-iqk1yiw4	324	6	are	be	VBP
cord-307860-iqk1yiw4	324	7	bolded	bolde	VBN
cord-307860-iqk1yiw4	324	8	and	and	CC
cord-307860-iqk1yiw4	324	9	the	the	DT
cord-307860-iqk1yiw4	324	10	basic	basic	JJ
cord-307860-iqk1yiw4	324	11	arginine	arginine	NN
cord-307860-iqk1yiw4	324	12	and	and	CC
cord-307860-iqk1yiw4	324	13	lysine	lysine	NN
cord-307860-iqk1yiw4	324	14	residues	residue	NNS
cord-307860-iqk1yiw4	324	15	are	be	VBP
cord-307860-iqk1yiw4	324	16	marked	mark	VBN
cord-307860-iqk1yiw4	324	17	in	in	IN
cord-307860-iqk1yiw4	324	18	red	red	JJ
cord-307860-iqk1yiw4	324	19	[	[	-LRB-
cord-307860-iqk1yiw4	324	20	93	93	CD
cord-307860-iqk1yiw4	324	21	]	]	-RRB-
cord-307860-iqk1yiw4	324	22	;	;	:
cord-307860-iqk1yiw4	324	23	in	in	IN
cord-307860-iqk1yiw4	324	24	yellow	yellow	JJ
cord-307860-iqk1yiw4	324	25	background	background	NN
cord-307860-iqk1yiw4	324	26	are	be	VBP
cord-307860-iqk1yiw4	324	27	marked	mark	VBN
cord-307860-iqk1yiw4	324	28	the	the	DT
cord-307860-iqk1yiw4	324	29	cysteine	cysteine	NN
cord-307860-iqk1yiw4	324	30	residues	residue	NNS
cord-307860-iqk1yiw4	324	31	that	that	WDT
cord-307860-iqk1yiw4	324	32	form	form	VBP
cord-307860-iqk1yiw4	324	33	an	an	DT
cord-307860-iqk1yiw4	324	34	internal	internal	JJ
cord-307860-iqk1yiw4	324	35	disulfide	disulfide	NN
cord-307860-iqk1yiw4	324	36	bond	bond	NN
cord-307860-iqk1yiw4	324	37	(	(	-LRB-
cord-307860-iqk1yiw4	324	38	C840	c840	PRP
cord-307860-iqk1yiw4	324	39	and	and	CC
cord-307860-iqk1yiw4	324	40	C851	C851	NNPS
cord-307860-iqk1yiw4	324	41	)	)	-RRB-
cord-307860-iqk1yiw4	324	42	and	and	CC
cord-307860-iqk1yiw4	324	43	the	the	DT
cord-307860-iqk1yiw4	324	44	residues	residue	NNS
cord-307860-iqk1yiw4	324	45	that	that	WDT
cord-307860-iqk1yiw4	324	46	form	form	VBP
cord-307860-iqk1yiw4	324	47	a	a	DT
cord-307860-iqk1yiw4	324	48	salt	salt	NN
cord-307860-iqk1yiw4	324	49	bridge	bridge	NN
cord-307860-iqk1yiw4	324	50	that	that	WDT
cord-307860-iqk1yiw4	324	51	reinforces	reinforce	VBZ
cord-307860-iqk1yiw4	324	52	the	the	DT
cord-307860-iqk1yiw4	324	53	previous	previous	JJ
cord-307860-iqk1yiw4	324	54	disulfide	disulfide	JJ
cord-307860-iqk1yiw4	324	55	bond	bond	NN
cord-307860-iqk1yiw4	324	56	(	(	-LRB-
cord-307860-iqk1yiw4	324	57	K835-D848	K835-D848	NNP
cord-307860-iqk1yiw4	324	58	)	)	-RRB-
cord-307860-iqk1yiw4	324	59	;	;	:
cord-307860-iqk1yiw4	324	60	in	in	IN
cord-307860-iqk1yiw4	324	61	light	light	JJ
cord-307860-iqk1yiw4	324	62	blue	blue	NN
cord-307860-iqk1yiw4	324	63	is	be	VBZ
cord-307860-iqk1yiw4	324	64	shown	show	VBN
cord-307860-iqk1yiw4	324	65	the	the	DT
cord-307860-iqk1yiw4	324	66	lysine	lysine	NN
cord-307860-iqk1yiw4	324	67	(	(	-LRB-
cord-307860-iqk1yiw4	324	68	K854	K854	NNP
cord-307860-iqk1yiw4	324	69	)	)	-RRB-
cord-307860-iqk1yiw4	324	70	that	that	WDT
cord-307860-iqk1yiw4	324	71	form	form	VBP
cord-307860-iqk1yiw4	324	72	a	a	DT
cord-307860-iqk1yiw4	324	73	salt	salt	NN
cord-307860-iqk1yiw4	324	74	bridge	bridge	NN
cord-307860-iqk1yiw4	324	75	with	with	IN
cord-307860-iqk1yiw4	324	76	the	the	DT
cord-307860-iqk1yiw4	324	77	aspartic	aspartic	JJ
cord-307860-iqk1yiw4	324	78	acid	acid	NN
cord-307860-iqk1yiw4	324	79	(	(	-LRB-
cord-307860-iqk1yiw4	324	80	D614	d614	NN
cord-307860-iqk1yiw4	324	81	)	)	-RRB-
cord-307860-iqk1yiw4	325	1	(	(	-LRB-
cord-307860-iqk1yiw4	325	2	not	not	RB
cord-307860-iqk1yiw4	325	3	shown	show	VBN
cord-307860-iqk1yiw4	325	4	)	)	-RRB-
cord-307860-iqk1yiw4	326	1	[	[	-LRB-
cord-307860-iqk1yiw4	326	2	40	40	CD
cord-307860-iqk1yiw4	326	3	,	,	,
cord-307860-iqk1yiw4	326	4	[	[	-LRB-
cord-307860-iqk1yiw4	326	5	107	107	CD
cord-307860-iqk1yiw4	326	6	]	]	-RRB-
cord-307860-iqk1yiw4	326	7	[	[	-LRB-
cord-307860-iqk1yiw4	326	8	108	108	CD
cord-307860-iqk1yiw4	326	9	]	]	-RRB-
cord-307860-iqk1yiw4	327	1	[	[	-LRB-
cord-307860-iqk1yiw4	327	2	109	109	CD
cord-307860-iqk1yiw4	327	3	]	]	-RRB-
cord-307860-iqk1yiw4	327	4	the	the	DT
cord-307860-iqk1yiw4	327	5	COVID-19	covid-19	NN
cord-307860-iqk1yiw4	327	6	.	.	.
cord-307860-iqk1yiw4	328	1	The	the	DT
cord-307860-iqk1yiw4	328	2	interaction	interaction	NN
cord-307860-iqk1yiw4	328	3	of	of	IN
cord-307860-iqk1yiw4	328	4	SARS	SARS	NNP
cord-307860-iqk1yiw4	328	5	-	-	HYPH
cord-307860-iqk1yiw4	328	6	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	328	7	with	with	IN
cord-307860-iqk1yiw4	328	8	the	the	DT
cord-307860-iqk1yiw4	328	9	human	human	JJ
cord-307860-iqk1yiw4	328	10	host	host	NN
cord-307860-iqk1yiw4	328	11	is	be	VBZ
cord-307860-iqk1yiw4	328	12	dynamic	dynamic	JJ
cord-307860-iqk1yiw4	328	13	and	and	CC
cord-307860-iqk1yiw4	328	14	has	have	VBZ
cord-307860-iqk1yiw4	328	15	new	new	JJ
cord-307860-iqk1yiw4	328	16	features	feature	NNS
cord-307860-iqk1yiw4	328	17	compared	compare	VBN
cord-307860-iqk1yiw4	328	18	to	to	IN
cord-307860-iqk1yiw4	328	19	other	other	JJ
cord-307860-iqk1yiw4	328	20	pandemics	pandemic	NNS
cord-307860-iqk1yiw4	328	21	in	in	IN
cord-307860-iqk1yiw4	328	22	human	human	JJ
cord-307860-iqk1yiw4	328	23	history	history	NN
cord-307860-iqk1yiw4	328	24	.	.	.
cord-307860-iqk1yiw4	329	1	First	first	RB
cord-307860-iqk1yiw4	329	2	,	,	,
cord-307860-iqk1yiw4	329	3	immunity	immunity	NN
cord-307860-iqk1yiw4	329	4	developed	develop	VBN
cord-307860-iqk1yiw4	329	5	after	after	IN
cord-307860-iqk1yiw4	329	6	the	the	DT
cord-307860-iqk1yiw4	329	7	SARS	SARS	NNP
cord-307860-iqk1yiw4	329	8	-	-	HYPH
cord-307860-iqk1yiw4	329	9	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	329	10	infection	infection	NN
cord-307860-iqk1yiw4	329	11	is	be	VBZ
cord-307860-iqk1yiw4	329	12	not	not	RB
cord-307860-iqk1yiw4	329	13	yet	yet	RB
cord-307860-iqk1yiw4	329	14	well	well	RB
cord-307860-iqk1yiw4	329	15	understood	understand	VBN
cord-307860-iqk1yiw4	329	16	[	[	-LRB-
cord-307860-iqk1yiw4	329	17	6	6	CD
cord-307860-iqk1yiw4	329	18	,	,	,
cord-307860-iqk1yiw4	329	19	122	122	CD
cord-307860-iqk1yiw4	329	20	,	,	,
cord-307860-iqk1yiw4	329	21	123	123	CD
cord-307860-iqk1yiw4	329	22	]	]	-RRB-
cord-307860-iqk1yiw4	329	23	.	.	.
cord-307860-iqk1yiw4	330	1	Then	then	RB
cord-307860-iqk1yiw4	330	2	,	,	,
cord-307860-iqk1yiw4	330	3	the	the	DT
cord-307860-iqk1yiw4	330	4	mechanisms	mechanism	NNS
cord-307860-iqk1yiw4	330	5	of	of	IN
cord-307860-iqk1yiw4	330	6	tissue	tissue	NN
cord-307860-iqk1yiw4	330	7	damage	damage	NN
cord-307860-iqk1yiw4	330	8	in	in	IN
cord-307860-iqk1yiw4	330	9	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	330	10	are	be	VBP
cord-307860-iqk1yiw4	330	11	not	not	RB
cord-307860-iqk1yiw4	330	12	fully	fully	RB
cord-307860-iqk1yiw4	330	13	understood	understand	VBN
cord-307860-iqk1yiw4	330	14	.	.	.
cord-307860-iqk1yiw4	331	1	The	the	DT
cord-307860-iqk1yiw4	331	2	most	most	RBS
cord-307860-iqk1yiw4	331	3	striking	striking	JJ
cord-307860-iqk1yiw4	331	4	characteristic	characteristic	NN
cord-307860-iqk1yiw4	331	5	of	of	IN
cord-307860-iqk1yiw4	331	6	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	331	7	is	be	VBZ
cord-307860-iqk1yiw4	331	8	the	the	DT
cord-307860-iqk1yiw4	331	9	storm	storm	NN
cord-307860-iqk1yiw4	331	10	of	of	IN
cord-307860-iqk1yiw4	331	11	proinflammatory	proinflammatory	JJ
cord-307860-iqk1yiw4	331	12	cytokines	cytokine	NNS
cord-307860-iqk1yiw4	331	13	that	that	WDT
cord-307860-iqk1yiw4	331	14	ultimately	ultimately	RB
cord-307860-iqk1yiw4	331	15	is	be	VBZ
cord-307860-iqk1yiw4	331	16	responsible	responsible	JJ
cord-307860-iqk1yiw4	331	17	for	for	IN
cord-307860-iqk1yiw4	331	18	the	the	DT
cord-307860-iqk1yiw4	331	19	vast	vast	JJ
cord-307860-iqk1yiw4	331	20	majority	majority	NN
cord-307860-iqk1yiw4	331	21	of	of	IN
cord-307860-iqk1yiw4	331	22	the	the	DT
cord-307860-iqk1yiw4	331	23	death	death	NN
cord-307860-iqk1yiw4	331	24	[	[	-LRB-
cord-307860-iqk1yiw4	331	25	124	124	CD
cord-307860-iqk1yiw4	331	26	]	]	-RRB-
cord-307860-iqk1yiw4	331	27	.	.	.
cord-307860-iqk1yiw4	332	1	The	the	DT
cord-307860-iqk1yiw4	332	2	biggest	big	JJS
cord-307860-iqk1yiw4	332	3	challenge	challenge	NN
cord-307860-iqk1yiw4	332	4	is	be	VBZ
cord-307860-iqk1yiw4	332	5	the	the	DT
cord-307860-iqk1yiw4	332	6	best	good	JJS
cord-307860-iqk1yiw4	332	7	protocol	protocol	NN
cord-307860-iqk1yiw4	332	8	to	to	TO
cord-307860-iqk1yiw4	332	9	treat	treat	VB
cord-307860-iqk1yiw4	332	10	critically	critically	RB
cord-307860-iqk1yiw4	332	11	ill	ill	JJ
cord-307860-iqk1yiw4	332	12	patients	patient	NNS
cord-307860-iqk1yiw4	332	13	.	.	.
cord-307860-iqk1yiw4	333	1	Methylprednisolone	Methylprednisolone	NNP
cord-307860-iqk1yiw4	333	2	has	have	VBZ
cord-307860-iqk1yiw4	333	3	already	already	RB
cord-307860-iqk1yiw4	333	4	been	be	VBN
cord-307860-iqk1yiw4	333	5	reported	report	VBN
cord-307860-iqk1yiw4	333	6	to	to	TO
cord-307860-iqk1yiw4	333	7	reduce	reduce	VB
cord-307860-iqk1yiw4	333	8	the	the	DT
cord-307860-iqk1yiw4	333	9	worst	bad	JJS
cord-307860-iqk1yiw4	333	10	outcomes	outcome	NNS
cord-307860-iqk1yiw4	333	11	(	(	-LRB-
cord-307860-iqk1yiw4	333	12	https	https	NNP
cord-307860-iqk1yiw4	333	13	:	:	:
cord-307860-iqk1yiw4	333	14	//advai	//advai	.
cord-307860-iqk1yiw4	334	1	tabio	tabio	NNP
cord-307860-iqk1yiw4	334	2	.com	.com	NNP
cord-307860-iqk1yiw4	334	3	/	/	SYM
cord-307860-iqk1yiw4	334	4	news	news	NN
cord-307860-iqk1yiw4	334	5	/	/	SYM
cord-307860-iqk1yiw4	334	6	covid	covid	NNP
cord-307860-iqk1yiw4	334	7	19-analy	19-analy	CD
cord-307860-iqk1yiw4	334	8	sis/	sis/	CD
cord-307860-iqk1yiw4	334	9	)	)	-RRB-
cord-307860-iqk1yiw4	334	10	[	[	-LRB-
cord-307860-iqk1yiw4	334	11	125	125	CD
cord-307860-iqk1yiw4	334	12	]	]	-RRB-
cord-307860-iqk1yiw4	334	13	.	.	.
cord-307860-iqk1yiw4	335	1	The	the	DT
cord-307860-iqk1yiw4	335	2	managing	managing	NN
cord-307860-iqk1yiw4	335	3	of	of	IN
cord-307860-iqk1yiw4	335	4	the	the	DT
cord-307860-iqk1yiw4	335	5	hyper	hyper	JJ
cord-307860-iqk1yiw4	335	6	-	-	JJ
cord-307860-iqk1yiw4	335	7	inflammatory	inflammatory	JJ
cord-307860-iqk1yiw4	335	8	process	process	NN
cord-307860-iqk1yiw4	335	9	in	in	IN
cord-307860-iqk1yiw4	335	10	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	335	11	proved	prove	VBN
cord-307860-iqk1yiw4	335	12	to	to	TO
cord-307860-iqk1yiw4	335	13	be	be	VB
cord-307860-iqk1yiw4	335	14	crucial	crucial	JJ
cord-307860-iqk1yiw4	335	15	for	for	IN
cord-307860-iqk1yiw4	335	16	the	the	DT
cord-307860-iqk1yiw4	335	17	evolution	evolution	NN
cord-307860-iqk1yiw4	335	18	of	of	IN
cord-307860-iqk1yiw4	335	19	the	the	DT
cord-307860-iqk1yiw4	335	20	disease	disease	NN
cord-307860-iqk1yiw4	335	21	.	.	.
cord-307860-iqk1yiw4	336	1	In	in	IN
cord-307860-iqk1yiw4	336	2	SARS	SARS	NNP
cord-307860-iqk1yiw4	336	3	-	-	HYPH
cord-307860-iqk1yiw4	336	4	CoV	CoV	NNP
cord-307860-iqk1yiw4	336	5	infections	infection	NNS
cord-307860-iqk1yiw4	336	6	,	,	,
cord-307860-iqk1yiw4	336	7	some	some	DT
cord-307860-iqk1yiw4	336	8	pro	pro	JJ
cord-307860-iqk1yiw4	336	9	-	-	JJ
cord-307860-iqk1yiw4	336	10	inflammatory	inflammatory	JJ
cord-307860-iqk1yiw4	336	11	cytokines	cytokine	NNS
cord-307860-iqk1yiw4	336	12	(	(	-LRB-
cord-307860-iqk1yiw4	336	13	IP-10	IP-10	NNP
cord-307860-iqk1yiw4	336	14	,	,	,
cord-307860-iqk1yiw4	336	15	IL-8	IL-8	NNP
cord-307860-iqk1yiw4	336	16	,	,	,
cord-307860-iqk1yiw4	336	17	and	and	CC
cord-307860-iqk1yiw4	336	18	MCP-1	MCP-1	NNP
cord-307860-iqk1yiw4	336	19	)	)	-RRB-
cord-307860-iqk1yiw4	336	20	are	be	VBP
cord-307860-iqk1yiw4	336	21	elevated	elevate	VBN
cord-307860-iqk1yiw4	336	22	.	.	.
cord-307860-iqk1yiw4	337	1	Meanwhile	meanwhile	RB
cord-307860-iqk1yiw4	337	2	,	,	,
cord-307860-iqk1yiw4	337	3	there	there	EX
cord-307860-iqk1yiw4	337	4	is	be	VBZ
cord-307860-iqk1yiw4	337	5	no	no	DT
cord-307860-iqk1yiw4	337	6	antiviral	antiviral	JJ
cord-307860-iqk1yiw4	337	7	(	(	-LRB-
cord-307860-iqk1yiw4	337	8	IFN	IFN	NNP
cord-307860-iqk1yiw4	337	9	)	)	-RRB-
cord-307860-iqk1yiw4	337	10	response	response	NN
cord-307860-iqk1yiw4	337	11	[	[	-LRB-
cord-307860-iqk1yiw4	337	12	126	126	CD
cord-307860-iqk1yiw4	337	13	]	]	-RRB-
cord-307860-iqk1yiw4	337	14	.	.	.
cord-307860-iqk1yiw4	338	1	In	in	IN
cord-307860-iqk1yiw4	338	2	many	many	JJ
cord-307860-iqk1yiw4	338	3	diseases	disease	NNS
cord-307860-iqk1yiw4	338	4	associated	associate	VBN
cord-307860-iqk1yiw4	338	5	with	with	IN
cord-307860-iqk1yiw4	338	6	systemic	systemic	JJ
cord-307860-iqk1yiw4	338	7	inflammatory	inflammatory	JJ
cord-307860-iqk1yiw4	338	8	response	response	NN
cord-307860-iqk1yiw4	338	9	syndrome	syndrome	NN
cord-307860-iqk1yiw4	338	10	,	,	,
cord-307860-iqk1yiw4	338	11	the	the	DT
cord-307860-iqk1yiw4	338	12	control	control	NN
cord-307860-iqk1yiw4	338	13	of	of	IN
cord-307860-iqk1yiw4	338	14	damage	damage	NN
cord-307860-iqk1yiw4	338	15	-	-	HYPH
cord-307860-iqk1yiw4	338	16	associated	associate	VBN
cord-307860-iqk1yiw4	338	17	molecular	molecular	JJ
cord-307860-iqk1yiw4	338	18	patterns	pattern	NNS
cord-307860-iqk1yiw4	338	19	(	(	-LRB-
cord-307860-iqk1yiw4	338	20	DAMPs	damp	NNS
cord-307860-iqk1yiw4	338	21	)	)	-RRB-
cord-307860-iqk1yiw4	338	22	by	by	IN
cord-307860-iqk1yiw4	338	23	their	-PRON-	PRP$
cord-307860-iqk1yiw4	338	24	counteracting	counteract	VBG
cord-307860-iqk1yiw4	338	25	molecules	molecule	NNS
cord-307860-iqk1yiw4	338	26	suppressing	suppress	VBG
cord-307860-iqk1yiw4	338	27	/	/	SYM
cord-307860-iqk1yiw4	338	28	inhibiting	inhibit	VBG
cord-307860-iqk1yiw4	338	29	DAMPs	damp	NNS
cord-307860-iqk1yiw4	338	30	(	(	-LRB-
cord-307860-iqk1yiw4	338	31	SAMPs	SAMPs	NNP
cord-307860-iqk1yiw4	338	32	)	)	-RRB-
cord-307860-iqk1yiw4	338	33	is	be	VBZ
cord-307860-iqk1yiw4	338	34	crucial	crucial	JJ
cord-307860-iqk1yiw4	338	35	[	[	-LRB-
cord-307860-iqk1yiw4	338	36	127	127	CD
cord-307860-iqk1yiw4	338	37	]	]	-RRB-
cord-307860-iqk1yiw4	338	38	.	.	.
cord-307860-iqk1yiw4	339	1	Previous	previous	JJ
cord-307860-iqk1yiw4	339	2	studies	study	NNS
cord-307860-iqk1yiw4	339	3	on	on	IN
cord-307860-iqk1yiw4	339	4	the	the	DT
cord-307860-iqk1yiw4	339	5	crystal	crystal	NN
cord-307860-iqk1yiw4	339	6	structures	structure	NNS
cord-307860-iqk1yiw4	339	7	of	of	IN
cord-307860-iqk1yiw4	339	8	SARS	SARS	NNP
cord-307860-iqk1yiw4	339	9	-	-	HYPH
cord-307860-iqk1yiw4	339	10	CoV	CoV	NNP
cord-307860-iqk1yiw4	339	11	S	S	NNP
cord-307860-iqk1yiw4	339	12	glycoprotein	glycoprotein	NN
cord-307860-iqk1yiw4	339	13	mutants	mutant	NNS
cord-307860-iqk1yiw4	339	14	neutralized	neutralize	VBN
cord-307860-iqk1yiw4	339	15	by	by	IN
cord-307860-iqk1yiw4	339	16	80R	80r	JJ
cord-307860-iqk1yiw4	339	17	-	-	HYPH
cord-307860-iqk1yiw4	339	18	specific	specific	JJ
cord-307860-iqk1yiw4	339	19	antibodies	antibody	NNS
cord-307860-iqk1yiw4	339	20	have	have	VBP
cord-307860-iqk1yiw4	339	21	been	be	VBN
cord-307860-iqk1yiw4	339	22	considered	consider	VBN
cord-307860-iqk1yiw4	339	23	a	a	DT
cord-307860-iqk1yiw4	339	24	hope	hope	NN
cord-307860-iqk1yiw4	339	25	for	for	IN
cord-307860-iqk1yiw4	339	26	the	the	DT
cord-307860-iqk1yiw4	339	27	immunotherapeutic	immunotherapeutic	JJ
cord-307860-iqk1yiw4	339	28	Fig	Fig	NNP
cord-307860-iqk1yiw4	339	29	.	.	.
cord-307860-iqk1yiw4	339	30	8	8	CD
cord-307860-iqk1yiw4	340	1	The	the	DT
cord-307860-iqk1yiw4	340	2	phylogenetic	phylogenetic	JJ
cord-307860-iqk1yiw4	340	3	tree	tree	NN
cord-307860-iqk1yiw4	340	4	(	(	-LRB-
cord-307860-iqk1yiw4	340	5	cladogram	cladogram	NN
cord-307860-iqk1yiw4	340	6	)	)	-RRB-
cord-307860-iqk1yiw4	340	7	of	of	IN
cord-307860-iqk1yiw4	340	8	the	the	DT
cord-307860-iqk1yiw4	340	9	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	340	10	Spike	Spike	NNP
cord-307860-iqk1yiw4	340	11	(	(	-LRB-
cord-307860-iqk1yiw4	340	12	S	s	NN
cord-307860-iqk1yiw4	340	13	)	)	-RRB-
cord-307860-iqk1yiw4	340	14	sequences	sequence	NNS
cord-307860-iqk1yiw4	340	15	of	of	IN
cord-307860-iqk1yiw4	340	16	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	340	17	with	with	IN
cord-307860-iqk1yiw4	340	18	different	different	JJ
cord-307860-iqk1yiw4	340	19	origin	origin	NN
cord-307860-iqk1yiw4	340	20	.	.	.
cord-307860-iqk1yiw4	341	1	feline	feline	JJ
cord-307860-iqk1yiw4	341	2	infectious	infectious	JJ
cord-307860-iqk1yiw4	341	3	peritonitis	peritonitis	NN
cord-307860-iqk1yiw4	341	4	virus	virus	NN
cord-307860-iqk1yiw4	341	5	(	(	-LRB-
cord-307860-iqk1yiw4	341	6	FIPV	FIPV	NNP
cord-307860-iqk1yiw4	341	7	)	)	-RRB-
cord-307860-iqk1yiw4	341	8	,	,	,
cord-307860-iqk1yiw4	341	9	porcine	porcine	JJ
cord-307860-iqk1yiw4	341	10	epidemic	epidemic	NN
cord-307860-iqk1yiw4	341	11	diarrhea	diarrhea	NN
cord-307860-iqk1yiw4	341	12	virus	virus	NN
cord-307860-iqk1yiw4	341	13	(	(	-LRB-
cord-307860-iqk1yiw4	341	14	PEDV	PEDV	NNP
cord-307860-iqk1yiw4	341	15	)	)	-RRB-
cord-307860-iqk1yiw4	341	16	,	,	,
cord-307860-iqk1yiw4	341	17	HCoV	HCoV	NNP
cord-307860-iqk1yiw4	341	18	-	-	HYPH
cord-307860-iqk1yiw4	341	19	NL63	NL63	NNP
cord-307860-iqk1yiw4	341	20	,	,	,
cord-307860-iqk1yiw4	341	21	SARS	SARS	NNP
cord-307860-iqk1yiw4	341	22	-	-	HYPH
cord-307860-iqk1yiw4	341	23	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	341	24	,	,	,
cord-307860-iqk1yiw4	341	25	SARS	SARS	NNP
cord-307860-iqk1yiw4	341	26	-	-	HYPH
cord-307860-iqk1yiw4	341	27	CoV	CoV	NNP
cord-307860-iqk1yiw4	341	28	,	,	,
cord-307860-iqk1yiw4	341	29	HCoV	HCoV	NNP
cord-307860-iqk1yiw4	341	30	-	-	HYPH
cord-307860-iqk1yiw4	341	31	HKU1	HKU1	NNP
cord-307860-iqk1yiw4	341	32	,	,	,
cord-307860-iqk1yiw4	341	33	and	and	CC
cord-307860-iqk1yiw4	341	34	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	341	35	(	(	-LRB-
cord-307860-iqk1yiw4	341	36	strain	strain	NN
cord-307860-iqk1yiw4	341	37	A59	A59	NNP
cord-307860-iqk1yiw4	341	38	)	)	-RRB-
cord-307860-iqk1yiw4	341	39	MHV	MHV	NNP
cord-307860-iqk1yiw4	341	40	-	-	HYPH
cord-307860-iqk1yiw4	341	41	A59	A59	NNP
cord-307860-iqk1yiw4	341	42	;	;	:
cord-307860-iqk1yiw4	341	43	performed	perform	VBN
cord-307860-iqk1yiw4	341	44	by	by	IN
cord-307860-iqk1yiw4	341	45	Clustal	Clustal	NNP
cord-307860-iqk1yiw4	341	46	Omega	Omega	NNP
cord-307860-iqk1yiw4	341	47	program	program	NN
cord-307860-iqk1yiw4	341	48	Fig	Fig	NNP
cord-307860-iqk1yiw4	341	49	.	.	.
cord-307860-iqk1yiw4	341	50	9	9	CD
cord-307860-iqk1yiw4	342	1	The	the	DT
cord-307860-iqk1yiw4	342	2	crystal	crystal	NN
cord-307860-iqk1yiw4	342	3	structures	structure	NNS
cord-307860-iqk1yiw4	342	4	co	co	VBD
cord-307860-iqk1yiw4	342	5	-	-	VBD
cord-307860-iqk1yiw4	342	6	crystallized	crystallize	VBN
cord-307860-iqk1yiw4	342	7	with	with	IN
cord-307860-iqk1yiw4	342	8	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	342	9	antibodies	antibody	NNS
cord-307860-iqk1yiw4	342	10	.	.	.
cord-307860-iqk1yiw4	343	1	The	the	DT
cord-307860-iqk1yiw4	343	2	epitopes	epitope	NNS
cord-307860-iqk1yiw4	343	3	of	of	IN
cord-307860-iqk1yiw4	343	4	the	the	DT
cord-307860-iqk1yiw4	343	5	SARS	SARS	NNP
cord-307860-iqk1yiw4	343	6	-	-	HYPH
cord-307860-iqk1yiw4	343	7	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	343	8	spike	spike	NN
cord-307860-iqk1yiw4	343	9	are	be	VBP
cord-307860-iqk1yiw4	343	10	NTD	NTD	NNP
cord-307860-iqk1yiw4	343	11	(	(	-LRB-
cord-307860-iqk1yiw4	343	12	N	n	CD
cord-307860-iqk1yiw4	343	13	terminal	terminal	NN
cord-307860-iqk1yiw4	343	14	domain	domain	NN
cord-307860-iqk1yiw4	343	15	)	)	-RRB-
cord-307860-iqk1yiw4	343	16	,	,	,
cord-307860-iqk1yiw4	343	17	RBD	RBD	NNP
cord-307860-iqk1yiw4	343	18	(	(	-LRB-
cord-307860-iqk1yiw4	343	19	receptor	receptor	NN
cord-307860-iqk1yiw4	343	20	binding	bind	VBG
cord-307860-iqk1yiw4	343	21	domain	domain	NN
cord-307860-iqk1yiw4	343	22	,	,	,
cord-307860-iqk1yiw4	343	23	quaternary	quaternary	JJ
cord-307860-iqk1yiw4	343	24	epitopes	epitope	NNS
cord-307860-iqk1yiw4	343	25	,	,	,
cord-307860-iqk1yiw4	343	26	and	and	CC
cord-307860-iqk1yiw4	343	27	ectodomain	ectodomain	NN
cord-307860-iqk1yiw4	343	28	;	;	:
cord-307860-iqk1yiw4	343	29	there	there	EX
cord-307860-iqk1yiw4	343	30	are	be	VBP
cord-307860-iqk1yiw4	343	31	indicated	indicate	VBN
cord-307860-iqk1yiw4	343	32	the	the	DT
cord-307860-iqk1yiw4	343	33	PDB	PDB	NNP
cord-307860-iqk1yiw4	343	34	entries	entry	NNS
cord-307860-iqk1yiw4	343	35	and	and	CC
cord-307860-iqk1yiw4	343	36	in	in	IN
cord-307860-iqk1yiw4	343	37	parenthesis	parenthesis	NN
cord-307860-iqk1yiw4	343	38	the	the	DT
cord-307860-iqk1yiw4	343	39	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	343	40	antibody	antibody	NN
cord-307860-iqk1yiw4	343	41	;	;	:
cord-307860-iqk1yiw4	343	42	*	*	NFP
cord-307860-iqk1yiw4	343	43	the	the	DT
cord-307860-iqk1yiw4	343	44	most	most	RBS
cord-307860-iqk1yiw4	343	45	potent	potent	JJ
cord-307860-iqk1yiw4	343	46	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	343	47	antibodies	antibody	NNS
cord-307860-iqk1yiw4	343	48	from	from	IN
cord-307860-iqk1yiw4	343	49	convalescent	convalescent	JJ
cord-307860-iqk1yiw4	343	50	patients	patient	NNS
cord-307860-iqk1yiw4	343	51	according	accord	VBG
cord-307860-iqk1yiw4	343	52	to	to	IN
cord-307860-iqk1yiw4	343	53	Liu	Liu	NNP
cord-307860-iqk1yiw4	343	54	et	et	NNP
cord-307860-iqk1yiw4	343	55	al	al	NNP
cord-307860-iqk1yiw4	343	56	.	.	.
cord-307860-iqk1yiw4	344	1	work	work	NN
cord-307860-iqk1yiw4	344	2	[	[	-LRB-
cord-307860-iqk1yiw4	344	3	16	16	CD
cord-307860-iqk1yiw4	344	4	]	]	-RRB-
cord-307860-iqk1yiw4	344	5	strategy	strategy	NN
cord-307860-iqk1yiw4	344	6	for	for	IN
cord-307860-iqk1yiw4	344	7	the	the	DT
cord-307860-iqk1yiw4	344	8	future	future	JJ
cord-307860-iqk1yiw4	344	9	outbreak	outbreak	NN
cord-307860-iqk1yiw4	344	10	of	of	IN
cord-307860-iqk1yiw4	344	11	SARS	SARS	NNP
cord-307860-iqk1yiw4	344	12	(	(	-LRB-
cord-307860-iqk1yiw4	344	13	PDB	PDB	NNP
cord-307860-iqk1yiw4	344	14	ID	ID	NNP
cord-307860-iqk1yiw4	344	15	2GHV	2ghv	CD
cord-307860-iqk1yiw4	344	16	)	)	-RRB-
cord-307860-iqk1yiw4	345	1	[	[	-LRB-
cord-307860-iqk1yiw4	345	2	128	128	CD
cord-307860-iqk1yiw4	345	3	]	]	-RRB-
cord-307860-iqk1yiw4	345	4	.	.	.
cord-307860-iqk1yiw4	346	1	There	there	EX
cord-307860-iqk1yiw4	346	2	are	be	VBP
cord-307860-iqk1yiw4	346	3	32	32	CD
cord-307860-iqk1yiw4	346	4	structures	structure	NNS
cord-307860-iqk1yiw4	346	5	of	of	IN
cord-307860-iqk1yiw4	346	6	SARS	SARS	NNP
cord-307860-iqk1yiw4	346	7	-	-	HYPH
cord-307860-iqk1yiw4	346	8	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	346	9	about	about	IN
cord-307860-iqk1yiw4	346	10	the	the	DT
cord-307860-iqk1yiw4	346	11	immune	immune	JJ
cord-307860-iqk1yiw4	346	12	system	system	NN
cord-307860-iqk1yiw4	346	13	published	publish	VBN
cord-307860-iqk1yiw4	346	14	in	in	IN
cord-307860-iqk1yiw4	346	15	peer	peer	NN
cord-307860-iqk1yiw4	346	16	-	-	HYPH
cord-307860-iqk1yiw4	346	17	reviewed	review	VBN
cord-307860-iqk1yiw4	346	18	papers	paper	NNS
cord-307860-iqk1yiw4	346	19	(	(	-LRB-
cord-307860-iqk1yiw4	346	20	PDB	PDB	NNP
cord-307860-iqk1yiw4	346	21	 	 	_SP
cord-307860-iqk1yiw4	346	22	ID9s	ID9s	NNP
cord-307860-iqk1yiw4	346	23	)	)	-RRB-
cord-307860-iqk1yiw4	346	24	6W41	6w41	CD
cord-307860-iqk1yiw4	346	25	,	,	,
cord-307860-iqk1yiw4	346	26	7BZ5	7bz5	CD
cord-307860-iqk1yiw4	346	27	,	,	,
cord-307860-iqk1yiw4	346	28	7C01	7c01	CD
cord-307860-iqk1yiw4	346	29	,	,	,
cord-307860-iqk1yiw4	346	30	7BWJ	7BWJ	NNP
cord-307860-iqk1yiw4	346	31	,	,	,
cord-307860-iqk1yiw4	346	32	7BYR	7BYR	NNP
cord-307860-iqk1yiw4	346	33	,	,	,
cord-307860-iqk1yiw4	346	34	6XCM	6xcm	UH
cord-307860-iqk1yiw4	346	35	,	,	,
cord-307860-iqk1yiw4	346	36	6XCN	6XCN	NNP
cord-307860-iqk1yiw4	346	37	,	,	,
cord-307860-iqk1yiw4	346	38	 	 	_SP
cord-307860-iqk1yiw4	346	39	7C2L	7c2l	CD
cord-307860-iqk1yiw4	346	40	,	,	,
cord-307860-iqk1yiw4	346	41	6XDG	6XDG	NNP
cord-307860-iqk1yiw4	346	42	,	,	,
cord-307860-iqk1yiw4	346	43	6YOR	6YOR	NNP
cord-307860-iqk1yiw4	346	44	,	,	,
cord-307860-iqk1yiw4	346	45	7CAH	7CAH	NNP
cord-307860-iqk1yiw4	346	46	,	,	,
cord-307860-iqk1yiw4	346	47	6XEY	6XEY	NNP
cord-307860-iqk1yiw4	346	48	,	,	,
cord-307860-iqk1yiw4	346	49	6ZCZ	6ZCZ	NNP
cord-307860-iqk1yiw4	346	50	,	,	,
cord-307860-iqk1yiw4	346	51	6ZDH	6ZDH	NNP
cord-307860-iqk1yiw4	346	52	,	,	,
cord-307860-iqk1yiw4	346	53	6ZDG	6zdg	CD
cord-307860-iqk1yiw4	346	54	,	,	,
cord-307860-iqk1yiw4	346	55	6ZER	6ZER	NNP
cord-307860-iqk1yiw4	346	56	,	,	,
cord-307860-iqk1yiw4	346	57	and	and	CC
cord-307860-iqk1yiw4	346	58	6ZFO	6zfo	CD
cord-307860-iqk1yiw4	346	59	)	)	-RRB-
cord-307860-iqk1yiw4	346	60	.	.	.
cord-307860-iqk1yiw4	347	1	More	More	JJR
cord-307860-iqk1yiw4	347	2	than	than	IN
cord-307860-iqk1yiw4	347	3	eight	eight	CD
cord-307860-iqk1yiw4	347	4	months	month	NNS
cord-307860-iqk1yiw4	347	5	after	after	IN
cord-307860-iqk1yiw4	347	6	the	the	DT
cord-307860-iqk1yiw4	347	7	onset	onset	NN
cord-307860-iqk1yiw4	347	8	of	of	IN
cord-307860-iqk1yiw4	347	9	the	the	DT
cord-307860-iqk1yiw4	347	10	pandemic	pandemic	NN
cord-307860-iqk1yiw4	347	11	,	,	,
cord-307860-iqk1yiw4	347	12	health	health	NN
cord-307860-iqk1yiw4	347	13	care	care	NN
cord-307860-iqk1yiw4	347	14	professionals	professional	NNS
cord-307860-iqk1yiw4	347	15	and	and	CC
cord-307860-iqk1yiw4	347	16	researchers	researcher	NNS
cord-307860-iqk1yiw4	347	17	are	be	VBP
cord-307860-iqk1yiw4	347	18	able	able	JJ
cord-307860-iqk1yiw4	347	19	to	to	TO
cord-307860-iqk1yiw4	347	20	analyze	analyze	VB
cord-307860-iqk1yiw4	347	21	the	the	DT
cord-307860-iqk1yiw4	347	22	clinical	clinical	JJ
cord-307860-iqk1yiw4	347	23	evolution	evolution	NN
cord-307860-iqk1yiw4	347	24	of	of	IN
cord-307860-iqk1yiw4	347	25	many	many	JJ
cord-307860-iqk1yiw4	347	26	patients	patient	NNS
cord-307860-iqk1yiw4	347	27	.	.	.
cord-307860-iqk1yiw4	348	1	The	the	DT
cord-307860-iqk1yiw4	348	2	host	host	NN
cord-307860-iqk1yiw4	348	3	immune	immune	JJ
cord-307860-iqk1yiw4	348	4	response	response	NN
cord-307860-iqk1yiw4	348	5	to	to	IN
cord-307860-iqk1yiw4	348	6	SARS	SARS	NNP
cord-307860-iqk1yiw4	348	7	-	-	HYPH
cord-307860-iqk1yiw4	348	8	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	348	9	infection	infection	NN
cord-307860-iqk1yiw4	348	10	is	be	VBZ
cord-307860-iqk1yiw4	348	11	perhaps	perhaps	RB
cord-307860-iqk1yiw4	348	12	the	the	DT
cord-307860-iqk1yiw4	348	13	most	most	RBS
cord-307860-iqk1yiw4	348	14	controversial	controversial	JJ
cord-307860-iqk1yiw4	348	15	issue	issue	NN
cord-307860-iqk1yiw4	348	16	.	.	.
cord-307860-iqk1yiw4	349	1	Most	Most	JJS
cord-307860-iqk1yiw4	349	2	of	of	IN
cord-307860-iqk1yiw4	349	3	the	the	DT
cord-307860-iqk1yiw4	349	4	last	last	JJ
cord-307860-iqk1yiw4	349	5	PDB	PDB	NNP
cord-307860-iqk1yiw4	349	6	entries	entry	NNS
cord-307860-iqk1yiw4	349	7	are	be	VBP
cord-307860-iqk1yiw4	349	8	about	about	IN
cord-307860-iqk1yiw4	349	9	the	the	DT
cord-307860-iqk1yiw4	349	10	SARS	SARS	NNP
cord-307860-iqk1yiw4	349	11	-	-	HYPH
cord-307860-iqk1yiw4	349	12	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	349	13	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	349	14	antibodies	antibody	NNS
cord-307860-iqk1yiw4	349	15	.	.	.
cord-307860-iqk1yiw4	350	1	The	the	DT
cord-307860-iqk1yiw4	350	2	patients	patient	NNS
cord-307860-iqk1yiw4	350	3	recovered	recover	VBD
cord-307860-iqk1yiw4	350	4	with	with	IN
cord-307860-iqk1yiw4	350	5	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	350	6	rapidly	rapidly	RB
cord-307860-iqk1yiw4	350	7	advanced	advance	VBN
cord-307860-iqk1yiw4	350	8	studies	study	NNS
cord-307860-iqk1yiw4	350	9	with	with	IN
cord-307860-iqk1yiw4	350	10	plasma	plasma	NN
cord-307860-iqk1yiw4	350	11	samples	sample	NNS
cord-307860-iqk1yiw4	350	12	from	from	IN
cord-307860-iqk1yiw4	350	13	convalescents	convalescent	NNS
cord-307860-iqk1yiw4	350	14	.	.	.
cord-307860-iqk1yiw4	351	1	Numerous	numerous	JJ
cord-307860-iqk1yiw4	351	2	research	research	NN
cord-307860-iqk1yiw4	351	3	teams	team	NNS
cord-307860-iqk1yiw4	351	4	already	already	RB
cord-307860-iqk1yiw4	351	5	identified	identify	VBD
cord-307860-iqk1yiw4	351	6	numerous	numerous	JJ
cord-307860-iqk1yiw4	351	7	potent	potent	JJ
cord-307860-iqk1yiw4	351	8	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	351	9	antibodies	antibody	NNS
cord-307860-iqk1yiw4	351	10	against	against	IN
cord-307860-iqk1yiw4	351	11	multiple	multiple	JJ
cord-307860-iqk1yiw4	351	12	epitopes	epitope	NNS
cord-307860-iqk1yiw4	351	13	on	on	IN
cord-307860-iqk1yiw4	351	14	the	the	DT
cord-307860-iqk1yiw4	351	15	SARS	SARS	NNP
cord-307860-iqk1yiw4	351	16	-	-	HYPH
cord-307860-iqk1yiw4	351	17	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	351	18	spike	spike	NN
cord-307860-iqk1yiw4	351	19	(	(	-LRB-
cord-307860-iqk1yiw4	351	20	Fig	fig	NN
cord-307860-iqk1yiw4	351	21	.	.	.
cord-307860-iqk1yiw4	351	22	9	9	CD
cord-307860-iqk1yiw4	351	23	)	)	-RRB-
cord-307860-iqk1yiw4	351	24	.	.	.
cord-307860-iqk1yiw4	352	1	Yuan	Yuan	NNP
cord-307860-iqk1yiw4	352	2	et	et	FW
cord-307860-iqk1yiw4	352	3	al	al	NNP
cord-307860-iqk1yiw4	352	4	.	.	.
cord-307860-iqk1yiw4	353	1	published	publish	VBD
cord-307860-iqk1yiw4	353	2	the	the	DT
cord-307860-iqk1yiw4	353	3	cryo	cryo	NN
cord-307860-iqk1yiw4	353	4	-	-	HYPH
cord-307860-iqk1yiw4	353	5	EM	EM	NNP
cord-307860-iqk1yiw4	353	6	crystal	crystal	NN
cord-307860-iqk1yiw4	353	7	structure	structure	NN
cord-307860-iqk1yiw4	353	8	of	of	IN
cord-307860-iqk1yiw4	353	9	the	the	DT
cord-307860-iqk1yiw4	353	10	SARS	SARS	NNP
cord-307860-iqk1yiw4	353	11	-	-	HYPH
cord-307860-iqk1yiw4	353	12	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	353	13	S1	s1	NN
cord-307860-iqk1yiw4	353	14	with	with	IN
cord-307860-iqk1yiw4	353	15	the	the	DT
cord-307860-iqk1yiw4	353	16	CR3022	cr3022	NN
cord-307860-iqk1yiw4	353	17	antibody	antibody	NN
cord-307860-iqk1yiw4	353	18	as	as	IN
cord-307860-iqk1yiw4	353	19	an	an	DT
cord-307860-iqk1yiw4	353	20	effort	effort	NN
cord-307860-iqk1yiw4	353	21	to	to	TO
cord-307860-iqk1yiw4	353	22	understand	understand	VB
cord-307860-iqk1yiw4	353	23	the	the	DT
cord-307860-iqk1yiw4	353	24	antigenicity	antigenicity	NN
cord-307860-iqk1yiw4	353	25	of	of	IN
cord-307860-iqk1yiw4	353	26	the	the	DT
cord-307860-iqk1yiw4	353	27	SARS	SARS	NNP
cord-307860-iqk1yiw4	353	28	-	-	HYPH
cord-307860-iqk1yiw4	353	29	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	353	30	(	(	-LRB-
cord-307860-iqk1yiw4	353	31	PDB	PDB	NNP
cord-307860-iqk1yiw4	353	32	ID	ID	NNP
cord-307860-iqk1yiw4	353	33	6W41	6w41	CD
cord-307860-iqk1yiw4	353	34	)	)	-RRB-
cord-307860-iqk1yiw4	353	35	.	.	.
cord-307860-iqk1yiw4	354	1	Their	-PRON-	PRP$
cord-307860-iqk1yiw4	354	2	results	result	NNS
cord-307860-iqk1yiw4	354	3	show	show	VBP
cord-307860-iqk1yiw4	354	4	that	that	IN
cord-307860-iqk1yiw4	354	5	CR3022	CR3022	VBZ
cord-307860-iqk1yiw4	354	6	Fab	Fab	NNP
cord-307860-iqk1yiw4	354	7	binds	bind	VBZ
cord-307860-iqk1yiw4	354	8	to	to	IN
cord-307860-iqk1yiw4	354	9	SARS	SARS	NNP
cord-307860-iqk1yiw4	354	10	-	-	HYPH
cord-307860-iqk1yiw4	354	11	CoV	cov	NN
cord-307860-iqk1yiw4	354	12	RBD	RBD	NNP
cord-307860-iqk1yiw4	354	13	with	with	IN
cord-307860-iqk1yiw4	354	14	higher	high	JJR
cord-307860-iqk1yiw4	354	15	affinity	affinity	NN
cord-307860-iqk1yiw4	354	16	(	(	-LRB-
cord-307860-iqk1yiw4	354	17	Table	table	NN
cord-307860-iqk1yiw4	354	18	2	2	CD
cord-307860-iqk1yiw4	354	19	)	)	-RRB-
cord-307860-iqk1yiw4	354	20	.	.	.
cord-307860-iqk1yiw4	355	1	In	in	IN
cord-307860-iqk1yiw4	355	2	the	the	DT
cord-307860-iqk1yiw4	355	3	selection	selection	NN
cord-307860-iqk1yiw4	355	4	process	process	NN
cord-307860-iqk1yiw4	355	5	of	of	IN
cord-307860-iqk1yiw4	355	6	the	the	DT
cord-307860-iqk1yiw4	355	7	selection	selection	NN
cord-307860-iqk1yiw4	355	8	of	of	IN
cord-307860-iqk1yiw4	355	9	the	the	DT
cord-307860-iqk1yiw4	355	10	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	355	11	antibodies	antibody	NNS
cord-307860-iqk1yiw4	355	12	against	against	IN
cord-307860-iqk1yiw4	355	13	SARS	SARS	NNP
cord-307860-iqk1yiw4	355	14	-	-	HYPH
cord-307860-iqk1yiw4	355	15	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	355	16	,	,	,
cord-307860-iqk1yiw4	355	17	Ju	Ju	NNP
cord-307860-iqk1yiw4	355	18	et	et	NNP
cord-307860-iqk1yiw4	355	19	al	al	NNP
cord-307860-iqk1yiw4	355	20	.	.	.
cord-307860-iqk1yiw4	356	1	provide	provide	VB
cord-307860-iqk1yiw4	356	2	evidence	evidence	NN
cord-307860-iqk1yiw4	356	3	that	that	IN
cord-307860-iqk1yiw4	356	4	binding	bind	VBG
cord-307860-iqk1yiw4	356	5	affinity	affinity	NN
cord-307860-iqk1yiw4	356	6	does	do	VBZ
cord-307860-iqk1yiw4	356	7	not	not	RB
cord-307860-iqk1yiw4	356	8	predict	predict	VB
cord-307860-iqk1yiw4	356	9	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	356	10	competing	compete	VBG
cord-307860-iqk1yiw4	356	11	capacity	capacity	NN
cord-307860-iqk1yiw4	356	12	[	[	-LRB-
cord-307860-iqk1yiw4	356	13	20	20	CD
cord-307860-iqk1yiw4	356	14	]	]	-RRB-
cord-307860-iqk1yiw4	356	15	.	.	.
cord-307860-iqk1yiw4	357	1	The	the	DT
cord-307860-iqk1yiw4	357	2	CR3022	cr3022	NN
cord-307860-iqk1yiw4	357	3	antibodies	antibody	NNS
cord-307860-iqk1yiw4	357	4	fail	fail	VBP
cord-307860-iqk1yiw4	357	5	to	to	TO
cord-307860-iqk1yiw4	357	6	neutralize	neutralize	VB
cord-307860-iqk1yiw4	357	7	SARS	SARS	NNP
cord-307860-iqk1yiw4	357	8	-	-	HYPH
cord-307860-iqk1yiw4	357	9	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	357	10	in	in	IN
cord-307860-iqk1yiw4	357	11	vitro	vitro	FW
cord-307860-iqk1yiw4	357	12	.	.	.
cord-307860-iqk1yiw4	358	1	The	the	DT
cord-307860-iqk1yiw4	358	2	CR3022	cr3022	NN
cord-307860-iqk1yiw4	358	3	epitope	epitope	NN
cord-307860-iqk1yiw4	358	4	does	do	VBZ
cord-307860-iqk1yiw4	358	5	not	not	RB
cord-307860-iqk1yiw4	358	6	overlap	overlap	VB
cord-307860-iqk1yiw4	358	7	with	with	IN
cord-307860-iqk1yiw4	358	8	the	the	DT
cord-307860-iqk1yiw4	358	9	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	358	10	binding	binding	NN
cord-307860-iqk1yiw4	358	11	site	site	NN
cord-307860-iqk1yiw4	358	12	in	in	IN
cord-307860-iqk1yiw4	358	13	SARS	SARS	NNP
cord-307860-iqk1yiw4	359	1	-CoV-2	-CoV-2	:
cord-307860-iqk1yiw4	359	2	S	S	NNP
cord-307860-iqk1yiw4	359	3	-	-	HYPH
cord-307860-iqk1yiw4	359	4	RBD	RBD	NNP
cord-307860-iqk1yiw4	359	5	.	.	.
cord-307860-iqk1yiw4	360	1	However	however	RB
cord-307860-iqk1yiw4	360	2	,	,	,
cord-307860-iqk1yiw4	360	3	SARS	SARS	NNP
cord-307860-iqk1yiw4	360	4	-	-	HYPH
cord-307860-iqk1yiw4	360	5	CoV	CoV	NNP
cord-307860-iqk1yiw4	360	6	and	and	CC
cord-307860-iqk1yiw4	360	7	SARS	SARS	NNP
cord-307860-iqk1yiw4	360	8	-	-	HYPH
cord-307860-iqk1yiw4	360	9	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	360	10	have	have	VBP
cord-307860-iqk1yiw4	360	11	a	a	DT
cord-307860-iqk1yiw4	360	12	conserved	conserve	VBN
cord-307860-iqk1yiw4	360	13	,	,	,
cord-307860-iqk1yiw4	360	14	but	but	CC
cord-307860-iqk1yiw4	360	15	cryptic	cryptic	JJ
cord-307860-iqk1yiw4	360	16	epitope	epitope	NN
cord-307860-iqk1yiw4	360	17	that	that	WDT
cord-307860-iqk1yiw4	360	18	could	could	MD
cord-307860-iqk1yiw4	360	19	be	be	VB
cord-307860-iqk1yiw4	360	20	worth	worth	JJ
cord-307860-iqk1yiw4	360	21	considering	consider	VBG
cord-307860-iqk1yiw4	360	22	for	for	IN
cord-307860-iqk1yiw4	360	23	a	a	DT
cord-307860-iqk1yiw4	360	24	vaccine	vaccine	NN
cord-307860-iqk1yiw4	360	25	[	[	-LRB-
cord-307860-iqk1yiw4	360	26	14	14	CD
cord-307860-iqk1yiw4	360	27	]	]	-RRB-
cord-307860-iqk1yiw4	360	28	.	.	.
cord-307860-iqk1yiw4	361	1	Moreover	moreover	RB
cord-307860-iqk1yiw4	361	2	,	,	,
cord-307860-iqk1yiw4	361	3	the	the	DT
cord-307860-iqk1yiw4	361	4	Huo	Huo	NNP
cord-307860-iqk1yiw4	361	5	et	et	NNP
cord-307860-iqk1yiw4	361	6	al	al	NNP
cord-307860-iqk1yiw4	361	7	.	.	NNP
cord-307860-iqk1yiw4	361	8	suggest	suggest	VB
cord-307860-iqk1yiw4	361	9	that	that	IN
cord-307860-iqk1yiw4	361	10	CR3022	cr3022	NN
cord-307860-iqk1yiw4	361	11	binding	binding	NN
cord-307860-iqk1yiw4	361	12	facilitates	facilitate	VBZ
cord-307860-iqk1yiw4	361	13	conversion	conversion	NN
cord-307860-iqk1yiw4	361	14	to	to	IN
cord-307860-iqk1yiw4	361	15	the	the	DT
cord-307860-iqk1yiw4	361	16	fusion	fusion	NN
cord-307860-iqk1yiw4	361	17	-	-	HYPH
cord-307860-iqk1yiw4	361	18	incompetent	incompetent	JJ
cord-307860-iqk1yiw4	361	19	post	post	JJ
cord-307860-iqk1yiw4	361	20	-	-	JJ
cord-307860-iqk1yiw4	361	21	fusion	fusion	JJ
cord-307860-iqk1yiw4	361	22	state	state	NN
cord-307860-iqk1yiw4	361	23	(	(	-LRB-
cord-307860-iqk1yiw4	361	24	PDB	PDB	NNP
cord-307860-iqk1yiw4	361	25	ID	ID	NNP
cord-307860-iqk1yiw4	361	26	6YOR	6YOR	NNP
cord-307860-iqk1yiw4	361	27	)	)	-RRB-
cord-307860-iqk1yiw4	361	28	[	[	-LRB-
cord-307860-iqk1yiw4	361	29	15	15	CD
cord-307860-iqk1yiw4	361	30	]	]	-RRB-
cord-307860-iqk1yiw4	361	31	.	.	.
cord-307860-iqk1yiw4	362	1	These	these	DT
cord-307860-iqk1yiw4	362	2	findings	finding	NNS
cord-307860-iqk1yiw4	362	3	offer	offer	VBP
cord-307860-iqk1yiw4	362	4	promising	promising	JJ
cord-307860-iqk1yiw4	362	5	perspectives	perspective	NNS
cord-307860-iqk1yiw4	362	6	on	on	IN
cord-307860-iqk1yiw4	362	7	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	362	8	therapy	therapy	NN
cord-307860-iqk1yiw4	362	9	with	with	IN
cord-307860-iqk1yiw4	362	10	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	362	11	antibodies	antibody	NNS
cord-307860-iqk1yiw4	362	12	.	.	.
cord-307860-iqk1yiw4	363	1	The	the	DT
cord-307860-iqk1yiw4	363	2	challenge	challenge	NN
cord-307860-iqk1yiw4	363	3	of	of	IN
cord-307860-iqk1yiw4	363	4	the	the	DT
cord-307860-iqk1yiw4	363	5	therapy	therapy	NN
cord-307860-iqk1yiw4	363	6	with	with	IN
cord-307860-iqk1yiw4	363	7	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	363	8	antibodies	antibody	NNS
cord-307860-iqk1yiw4	363	9	is	be	VBZ
cord-307860-iqk1yiw4	363	10	to	to	TO
cord-307860-iqk1yiw4	363	11	overcome	overcome	VB
cord-307860-iqk1yiw4	363	12	the	the	DT
cord-307860-iqk1yiw4	363	13	virus	virus	NN
cord-307860-iqk1yiw4	363	14	mutants	mutant	NNS
cord-307860-iqk1yiw4	363	15	.	.	.
cord-307860-iqk1yiw4	364	1	The	the	DT
cord-307860-iqk1yiw4	364	2	therapeutic	therapeutic	JJ
cord-307860-iqk1yiw4	364	3	cocktail	cocktail	NN
cord-307860-iqk1yiw4	364	4	of	of	IN
cord-307860-iqk1yiw4	364	5	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	364	6	antibodies	antibody	NNS
cord-307860-iqk1yiw4	364	7	against	against	IN
cord-307860-iqk1yiw4	364	8	SARS	SARS	NNP
cord-307860-iqk1yiw4	364	9	-	-	HYPH
cord-307860-iqk1yiw4	364	10	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	364	11	is	be	VBZ
cord-307860-iqk1yiw4	364	12	an	an	DT
cord-307860-iqk1yiw4	364	13	efficient	efficient	JJ
cord-307860-iqk1yiw4	364	14	approach	approach	NN
cord-307860-iqk1yiw4	364	15	.	.	.
cord-307860-iqk1yiw4	365	1	The	the	DT
cord-307860-iqk1yiw4	365	2	Hansen	Hansen	NNP
cord-307860-iqk1yiw4	365	3	et	et	NNP
cord-307860-iqk1yiw4	365	4	al	al	NNP
cord-307860-iqk1yiw4	365	5	.	.	.
cord-307860-iqk1yiw4	365	6	team	team	NN
cord-307860-iqk1yiw4	365	7	discovered	discover	VBD
cord-307860-iqk1yiw4	365	8	a	a	DT
cord-307860-iqk1yiw4	365	9	pair	pair	NN
cord-307860-iqk1yiw4	365	10	of	of	IN
cord-307860-iqk1yiw4	365	11	non	non	JJ
cord-307860-iqk1yiw4	365	12	-	-	JJ
cord-307860-iqk1yiw4	365	13	competitive	competitive	JJ
cord-307860-iqk1yiw4	365	14	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	365	15	antibodies	antibody	NNS
cord-307860-iqk1yiw4	365	16	that	that	WDT
cord-307860-iqk1yiw4	365	17	simultaneously	simultaneously	RB
cord-307860-iqk1yiw4	365	18	bind	bind	VBP
cord-307860-iqk1yiw4	365	19	to	to	IN
cord-307860-iqk1yiw4	365	20	S	S	NNP
cord-307860-iqk1yiw4	365	21	-	-	HYPH
cord-307860-iqk1yiw4	365	22	RBD	RBD	NNP
cord-307860-iqk1yiw4	365	23	SARS	SARS	NNP
cord-307860-iqk1yiw4	365	24	-	-	HYPH
cord-307860-iqk1yiw4	365	25	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	365	26	(	(	-LRB-
cord-307860-iqk1yiw4	365	27	namely	namely	RB
cord-307860-iqk1yiw4	365	28	REGN10933	REGN10933	NNP
cord-307860-iqk1yiw4	365	29	and	and	CC
cord-307860-iqk1yiw4	365	30	REGN10987	REGN10987	NNP
cord-307860-iqk1yiw4	365	31	)	)	-RRB-
cord-307860-iqk1yiw4	366	1	(	(	-LRB-
cord-307860-iqk1yiw4	366	2	PDB	PDB	NNP
cord-307860-iqk1yiw4	366	3	ID	ID	NNP
cord-307860-iqk1yiw4	366	4	6XDG	6XDG	NNP
cord-307860-iqk1yiw4	366	5	)	)	-RRB-
cord-307860-iqk1yiw4	367	1	[	[	-LRB-
cord-307860-iqk1yiw4	367	2	23	23	CD
cord-307860-iqk1yiw4	367	3	]	]	-RRB-
cord-307860-iqk1yiw4	367	4	.	.	.
cord-307860-iqk1yiw4	368	1	The	the	DT
cord-307860-iqk1yiw4	368	2	mapping	mapping	NN
cord-307860-iqk1yiw4	368	3	of	of	IN
cord-307860-iqk1yiw4	368	4	the	the	DT
cord-307860-iqk1yiw4	368	5	SARS	SARS	NNP
cord-307860-iqk1yiw4	368	6	-	-	HYPH
cord-307860-iqk1yiw4	368	7	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	368	8	epitopes	epitope	NNS
cord-307860-iqk1yiw4	368	9	targeted	target	VBN
cord-307860-iqk1yiw4	368	10	by	by	IN
cord-307860-iqk1yiw4	368	11	potent	potent	JJ
cord-307860-iqk1yiw4	368	12	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	368	13	mAbs	mAbs	NNP
cord-307860-iqk1yiw4	368	14	demonstrated	demonstrate	VBD
cord-307860-iqk1yiw4	368	15	the	the	DT
cord-307860-iqk1yiw4	368	16	diversity	diversity	NN
cord-307860-iqk1yiw4	368	17	of	of	IN
cord-307860-iqk1yiw4	368	18	the	the	DT
cord-307860-iqk1yiw4	368	19	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	368	20	antibodies	antibody	NNS
cord-307860-iqk1yiw4	368	21	directed	direct	VBN
cord-307860-iqk1yiw4	368	22	against	against	IN
cord-307860-iqk1yiw4	368	23	the	the	DT
cord-307860-iqk1yiw4	368	24	S	S	NNP
cord-307860-iqk1yiw4	368	25	-	-	HYPH
cord-307860-iqk1yiw4	368	26	RBD	RBD	NNP
cord-307860-iqk1yiw4	368	27	,	,	,
cord-307860-iqk1yiw4	368	28	S	S	NNP
cord-307860-iqk1yiw4	368	29	-	-	HYPH
cord-307860-iqk1yiw4	368	30	NTD	NTD	NNP
cord-307860-iqk1yiw4	368	31	,	,	,
cord-307860-iqk1yiw4	368	32	and	and	CC
cord-307860-iqk1yiw4	368	33	the	the	DT
cord-307860-iqk1yiw4	368	34	epitopes	epitope	NNS
cord-307860-iqk1yiw4	368	35	that	that	WDT
cord-307860-iqk1yiw4	368	36	do	do	VBP
cord-307860-iqk1yiw4	368	37	not	not	RB
cord-307860-iqk1yiw4	368	38	map	map	VB
cord-307860-iqk1yiw4	368	39	to	to	IN
cord-307860-iqk1yiw4	368	40	the	the	DT
cord-307860-iqk1yiw4	368	41	S	S	NNP
cord-307860-iqk1yiw4	368	42	-	-	HYPH
cord-307860-iqk1yiw4	368	43	RBD	RBD	NNP
cord-307860-iqk1yiw4	368	44	or	or	CC
cord-307860-iqk1yiw4	368	45	S	S	NNP
cord-307860-iqk1yiw4	368	46	-	-	HYPH
cord-307860-iqk1yiw4	368	47	NTD	NTD	NNP
cord-307860-iqk1yiw4	368	48	.	.	.
cord-307860-iqk1yiw4	369	1	Even	even	RB
cord-307860-iqk1yiw4	369	2	though	though	IN
cord-307860-iqk1yiw4	369	3	the	the	DT
cord-307860-iqk1yiw4	369	4	authors	author	NNS
cord-307860-iqk1yiw4	369	5	Liu	Liu	NNP
cord-307860-iqk1yiw4	369	6	et	et	NNP
cord-307860-iqk1yiw4	369	7	al	al	NNP
cord-307860-iqk1yiw4	369	8	.	.	.
cord-307860-iqk1yiw4	369	9	do	do	VB
cord-307860-iqk1yiw4	369	10	not	not	RB
cord-307860-iqk1yiw4	369	11	establish	establish	VB
cord-307860-iqk1yiw4	369	12	the	the	DT
cord-307860-iqk1yiw4	369	13	role	role	NN
cord-307860-iqk1yiw4	369	14	of	of	IN
cord-307860-iqk1yiw4	369	15	S	S	NNP
cord-307860-iqk1yiw4	369	16	-	-	HYPH
cord-307860-iqk1yiw4	369	17	NTD	NTD	NNP
cord-307860-iqk1yiw4	369	18	in	in	IN
cord-307860-iqk1yiw4	369	19	[	[	-LRB-
cord-307860-iqk1yiw4	369	20	16	16	CD
cord-307860-iqk1yiw4	369	21	]	]	-RRB-
cord-307860-iqk1yiw4	369	22	blocking	block	VBG
cord-307860-iqk1yiw4	369	23	SARS	SARS	NNP
cord-307860-iqk1yiw4	369	24	-	-	HYPH
cord-307860-iqk1yiw4	369	25	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	369	26	infection	infection	NN
cord-307860-iqk1yiw4	369	27	,	,	,
cord-307860-iqk1yiw4	369	28	these	these	DT
cord-307860-iqk1yiw4	369	29	findings	finding	NNS
cord-307860-iqk1yiw4	369	30	are	be	VBP
cord-307860-iqk1yiw4	369	31	crucial	crucial	JJ
cord-307860-iqk1yiw4	369	32	for	for	IN
cord-307860-iqk1yiw4	369	33	vaccine	vaccine	NN
cord-307860-iqk1yiw4	369	34	development	development	NN
cord-307860-iqk1yiw4	369	35	[	[	-LRB-
cord-307860-iqk1yiw4	369	36	16	16	CD
cord-307860-iqk1yiw4	369	37	]	]	-RRB-
cord-307860-iqk1yiw4	369	38	.	.	.
cord-307860-iqk1yiw4	370	1	The	the	DT
cord-307860-iqk1yiw4	370	2	studies	study	NNS
cord-307860-iqk1yiw4	370	3	about	about	IN
cord-307860-iqk1yiw4	370	4	the	the	DT
cord-307860-iqk1yiw4	370	5	host	host	NN
cord-307860-iqk1yiw4	370	6	immune	immune	JJ
cord-307860-iqk1yiw4	370	7	system	system	NN
cord-307860-iqk1yiw4	370	8	are	be	VBP
cord-307860-iqk1yiw4	370	9	,	,	,
cord-307860-iqk1yiw4	370	10	on	on	IN
cord-307860-iqk1yiw4	370	11	the	the	DT
cord-307860-iqk1yiw4	370	12	one	one	CD
cord-307860-iqk1yiw4	370	13	hand	hand	NN
cord-307860-iqk1yiw4	370	14	,	,	,
cord-307860-iqk1yiw4	370	15	about	about	IN
cord-307860-iqk1yiw4	370	16	the	the	DT
cord-307860-iqk1yiw4	370	17	production	production	NN
cord-307860-iqk1yiw4	370	18	of	of	IN
cord-307860-iqk1yiw4	370	19	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	370	20	antibodies	antibody	NNS
cord-307860-iqk1yiw4	370	21	,	,	,
cord-307860-iqk1yiw4	370	22	and	and	CC
cord-307860-iqk1yiw4	370	23	on	on	IN
cord-307860-iqk1yiw4	370	24	the	the	DT
cord-307860-iqk1yiw4	370	25	other	other	JJ
cord-307860-iqk1yiw4	370	26	hand	hand	NN
cord-307860-iqk1yiw4	370	27	,	,	,
cord-307860-iqk1yiw4	370	28	about	about	IN
cord-307860-iqk1yiw4	370	29	the	the	DT
cord-307860-iqk1yiw4	370	30	virus	virus	NN
cord-307860-iqk1yiw4	370	31	's	's	POS
cord-307860-iqk1yiw4	370	32	ability	ability	NN
cord-307860-iqk1yiw4	370	33	to	to	TO
cord-307860-iqk1yiw4	370	34	hamper	hamper	VB
cord-307860-iqk1yiw4	370	35	defense	defense	NN
cord-307860-iqk1yiw4	370	36	immunity	immunity	NN
cord-307860-iqk1yiw4	370	37	.	.	.
cord-307860-iqk1yiw4	371	1	The	the	DT
cord-307860-iqk1yiw4	371	2	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	371	3	have	have	VBP
cord-307860-iqk1yiw4	371	4	an	an	DT
cord-307860-iqk1yiw4	371	5	impressive	impressive	JJ
cord-307860-iqk1yiw4	371	6	ability	ability	NN
cord-307860-iqk1yiw4	371	7	to	to	TO
cord-307860-iqk1yiw4	371	8	suppress	suppress	VB
cord-307860-iqk1yiw4	371	9	the	the	DT
cord-307860-iqk1yiw4	371	10	IFN	IFN	NNP
cord-307860-iqk1yiw4	371	11	response	response	NN
cord-307860-iqk1yiw4	371	12	.	.	.
cord-307860-iqk1yiw4	372	1	An	an	DT
cord-307860-iqk1yiw4	372	2	antagonist	antagonist	NN
cord-307860-iqk1yiw4	372	3	of	of	IN
cord-307860-iqk1yiw4	372	4	the	the	DT
cord-307860-iqk1yiw4	372	5	IFN	IFN	NNP
cord-307860-iqk1yiw4	372	6	response	response	NN
cord-307860-iqk1yiw4	372	7	is	be	VBZ
cord-307860-iqk1yiw4	372	8	the	the	DT
cord-307860-iqk1yiw4	372	9	nsp15	nsp15	CD
cord-307860-iqk1yiw4	372	10	[	[	-LRB-
cord-307860-iqk1yiw4	372	11	129	129	CD
cord-307860-iqk1yiw4	372	12	]	]	-RRB-
cord-307860-iqk1yiw4	372	13	.	.	.
cord-307860-iqk1yiw4	373	1	The	the	DT
cord-307860-iqk1yiw4	373	2	viral	viral	JJ
cord-307860-iqk1yiw4	373	3	nsp3	nsp3	NNS
cord-307860-iqk1yiw4	373	4	has	have	VBZ
cord-307860-iqk1yiw4	373	5	an	an	DT
cord-307860-iqk1yiw4	373	6	active	active	JJ
cord-307860-iqk1yiw4	373	7	role	role	NN
cord-307860-iqk1yiw4	373	8	in	in	IN
cord-307860-iqk1yiw4	373	9	suppressing	suppress	VBG
cord-307860-iqk1yiw4	373	10	innate	innate	JJ
cord-307860-iqk1yiw4	373	11	immunity	immunity	NN
cord-307860-iqk1yiw4	373	12	by	by	IN
cord-307860-iqk1yiw4	373	13	blocking	block	VBG
cord-307860-iqk1yiw4	373	14	the	the	DT
cord-307860-iqk1yiw4	373	15	interferon	interferon	NN
cord-307860-iqk1yiw4	373	16	regulatory	regulatory	JJ
cord-307860-iqk1yiw4	373	17	factor	factor	NN
cord-307860-iqk1yiw4	373	18	(	(	-LRB-
cord-307860-iqk1yiw4	373	19	IRF3	IRF3	NNP
cord-307860-iqk1yiw4	373	20	)	)	-RRB-
cord-307860-iqk1yiw4	374	1	(	(	-LRB-
cord-307860-iqk1yiw4	374	2	Gene	Gene	NNP
cord-307860-iqk1yiw4	374	3	ID	ID	NNP
cord-307860-iqk1yiw4	374	4	3661	3661	CD
cord-307860-iqk1yiw4	374	5	)	)	-RRB-
cord-307860-iqk1yiw4	374	6	and	and	CC
cord-307860-iqk1yiw4	374	7	altering	alter	VBG
cord-307860-iqk1yiw4	374	8	the	the	DT
cord-307860-iqk1yiw4	374	9	NF	NF	NNP
cord-307860-iqk1yiw4	374	10	-	-	HYPH
cord-307860-iqk1yiw4	374	11	kappaB	kappaB	NNP
cord-307860-iqk1yiw4	374	12	signaling	signaling	NN
cord-307860-iqk1yiw4	374	13	,	,	,
cord-307860-iqk1yiw4	374	14	which	which	WDT
cord-307860-iqk1yiw4	374	15	controls	control	VBZ
cord-307860-iqk1yiw4	374	16	the	the	DT
cord-307860-iqk1yiw4	374	17	expression	expression	NN
cord-307860-iqk1yiw4	374	18	of	of	IN
cord-307860-iqk1yiw4	374	19	some	some	DT
cord-307860-iqk1yiw4	374	20	inflammatory	inflammatory	JJ
cord-307860-iqk1yiw4	374	21	cytokine	cytokine	NN
cord-307860-iqk1yiw4	374	22	genes	gene	NNS
cord-307860-iqk1yiw4	374	23	[	[	-LRB-
cord-307860-iqk1yiw4	374	24	130	130	CD
cord-307860-iqk1yiw4	374	25	,	,	,
cord-307860-iqk1yiw4	374	26	131	131	CD
cord-307860-iqk1yiw4	374	27	]	]	-RRB-
cord-307860-iqk1yiw4	374	28	.	.	.
cord-307860-iqk1yiw4	375	1	The	the	DT
cord-307860-iqk1yiw4	375	2	nsp3	nsp3	NNS
cord-307860-iqk1yiw4	375	3	has	have	VBZ
cord-307860-iqk1yiw4	375	4	a	a	DT
cord-307860-iqk1yiw4	375	5	crucial	crucial	JJ
cord-307860-iqk1yiw4	375	6	role	role	NN
cord-307860-iqk1yiw4	375	7	in	in	IN
cord-307860-iqk1yiw4	375	8	damaging	damage	VBG
cord-307860-iqk1yiw4	375	9	the	the	DT
cord-307860-iqk1yiw4	375	10	host	host	NN
cord-307860-iqk1yiw4	375	11	's	's	POS
cord-307860-iqk1yiw4	375	12	first	first	JJ
cord-307860-iqk1yiw4	375	13	line	line	NN
cord-307860-iqk1yiw4	375	14	of	of	IN
cord-307860-iqk1yiw4	375	15	defense	defense	NN
cord-307860-iqk1yiw4	375	16	against	against	IN
cord-307860-iqk1yiw4	375	17	SARS	SARS	NNP
cord-307860-iqk1yiw4	375	18	-	-	HYPH
cord-307860-iqk1yiw4	375	19	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	375	20	.	.	.
cord-307860-iqk1yiw4	376	1	Nsp3	Nsp3	NNS
cord-307860-iqk1yiw4	376	2	probably	probably	RB
cord-307860-iqk1yiw4	376	3	has	have	VBZ
cord-307860-iqk1yiw4	376	4	a	a	DT
cord-307860-iqk1yiw4	376	5	role	role	NN
cord-307860-iqk1yiw4	376	6	in	in	IN
cord-307860-iqk1yiw4	376	7	producing	produce	VBG
cord-307860-iqk1yiw4	376	8	the	the	DT
cord-307860-iqk1yiw4	376	9	unusual	unusual	JJ
cord-307860-iqk1yiw4	376	10	inflammation	inflammation	NN
cord-307860-iqk1yiw4	376	11	described	describe	VBN
cord-307860-iqk1yiw4	376	12	in	in	IN
cord-307860-iqk1yiw4	376	13	patients	patient	NNS
cord-307860-iqk1yiw4	376	14	with	with	IN
cord-307860-iqk1yiw4	376	15	severe	severe	JJ
cord-307860-iqk1yiw4	376	16	COVID-19	covid-19	JJ
cord-307860-iqk1yiw4	376	17	[	[	-LRB-
cord-307860-iqk1yiw4	376	18	132	132	CD
cord-307860-iqk1yiw4	376	19	]	]	-RRB-
cord-307860-iqk1yiw4	376	20	.	.	.
cord-307860-iqk1yiw4	377	1	The	the	DT
cord-307860-iqk1yiw4	377	2	SARS	SARS	NNP
cord-307860-iqk1yiw4	377	3	-	-	HYPH
cord-307860-iqk1yiw4	377	4	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	377	5	nsp3	nsp3	NNS
cord-307860-iqk1yiw4	377	6	has	have	VBZ
cord-307860-iqk1yiw4	377	7	no	no	DT
cord-307860-iqk1yiw4	377	8	crystal	crystal	NN
cord-307860-iqk1yiw4	377	9	structures	structure	NNS
cord-307860-iqk1yiw4	377	10	published	publish	VBN
cord-307860-iqk1yiw4	377	11	until	until	IN
cord-307860-iqk1yiw4	377	12	now	now	RB
cord-307860-iqk1yiw4	377	13	.	.	.
cord-307860-iqk1yiw4	378	1	The	the	DT
cord-307860-iqk1yiw4	378	2	nsp3	nsp3	NNS
cord-307860-iqk1yiw4	378	3	(	(	-LRB-
cord-307860-iqk1yiw4	378	4	~	~	NFP
cord-307860-iqk1yiw4	378	5	200	200	CD
cord-307860-iqk1yiw4	378	6	kDa	kDa	NNPS
cord-307860-iqk1yiw4	378	7	)	)	-RRB-
cord-307860-iqk1yiw4	378	8	is	be	VBZ
cord-307860-iqk1yiw4	378	9	a	a	DT
cord-307860-iqk1yiw4	378	10	large	large	JJ
cord-307860-iqk1yiw4	378	11	multidomain	multidomain	NN
cord-307860-iqk1yiw4	378	12	protein	protein	NN
cord-307860-iqk1yiw4	378	13	(	(	-LRB-
cord-307860-iqk1yiw4	378	14	E.C.	E.C.	NNP
cord-307860-iqk1yiw4	378	15	3.4.19.12	3.4.19.12	CD
cord-307860-iqk1yiw4	378	16	)	)	-RRB-
cord-307860-iqk1yiw4	378	17	(	(	-LRB-
cord-307860-iqk1yiw4	378	18	UniProtUK	uniprotuk	CD
cord-307860-iqk1yiw4	378	19	P0DTD1	P0DTD1	NNP
cord-307860-iqk1yiw4	378	20	)	)	-RRB-
cord-307860-iqk1yiw4	378	21	responsible	responsible	JJ
cord-307860-iqk1yiw4	378	22	for	for	IN
cord-307860-iqk1yiw4	378	23	the	the	DT
cord-307860-iqk1yiw4	378	24	cleavage	cleavage	NN
cord-307860-iqk1yiw4	378	25	of	of	IN
cord-307860-iqk1yiw4	378	26	the	the	DT
cord-307860-iqk1yiw4	378	27	replicase	replicase	NNP
cord-307860-iqk1yiw4	378	28	polyprotein	polyprotein	NNP
cord-307860-iqk1yiw4	378	29	1ab	1ab	NNP
cord-307860-iqk1yiw4	378	30	at	at	IN
cord-307860-iqk1yiw4	378	31	the	the	DT
cord-307860-iqk1yiw4	378	32	N	n	CD
cord-307860-iqk1yiw4	378	33	-	-	HYPH
cord-307860-iqk1yiw4	378	34	terminus	terminus	NN
cord-307860-iqk1yiw4	378	35	[	[	-LRB-
cord-307860-iqk1yiw4	378	36	133	133	CD
cord-307860-iqk1yiw4	378	37	]	]	-RRB-
cord-307860-iqk1yiw4	378	38	.	.	.
cord-307860-iqk1yiw4	379	1	The	the	DT
cord-307860-iqk1yiw4	379	2	papain	papain	NN
cord-307860-iqk1yiw4	379	3	-	-	HYPH
cord-307860-iqk1yiw4	379	4	like	like	JJ
cord-307860-iqk1yiw4	379	5	protease	protease	NN
cord-307860-iqk1yiw4	379	6	(	(	-LRB-
cord-307860-iqk1yiw4	379	7	PL	pl	NN
cord-307860-iqk1yiw4	379	8	pro	pro	NN
cord-307860-iqk1yiw4	379	9	)	)	-RRB-
cord-307860-iqk1yiw4	379	10	domain	domain	NN
cord-307860-iqk1yiw4	379	11	of	of	IN
cord-307860-iqk1yiw4	379	12	the	the	DT
cord-307860-iqk1yiw4	379	13	viral	viral	JJ
cord-307860-iqk1yiw4	379	14	nsp3	nsp3	NNS
cord-307860-iqk1yiw4	379	15	exhibits	exhibit	VBZ
cord-307860-iqk1yiw4	379	16	deubiquitinating	deubiquitinate	VBG
cord-307860-iqk1yiw4	379	17	activity	activity	NN
cord-307860-iqk1yiw4	379	18	[	[	-LRB-
cord-307860-iqk1yiw4	379	19	134	134	CD
cord-307860-iqk1yiw4	379	20	]	]	-RRB-
cord-307860-iqk1yiw4	379	21	.	.	.
cord-307860-iqk1yiw4	380	1	A	a	DT
cord-307860-iqk1yiw4	380	2	recent	recent	JJ
cord-307860-iqk1yiw4	380	3	study	study	NN
cord-307860-iqk1yiw4	380	4	has	have	VBZ
cord-307860-iqk1yiw4	380	5	shown	show	VBN
cord-307860-iqk1yiw4	380	6	that	that	IN
cord-307860-iqk1yiw4	380	7	deubiquitinating	deubiquitinating	NN
cord-307860-iqk1yiw4	380	8	/	/	SYM
cord-307860-iqk1yiw4	380	9	deIS	deIS	NNP
cord-307860-iqk1yiw4	380	10	-	-	HYPH
cord-307860-iqk1yiw4	380	11	Gylating	Gylating	NNP
cord-307860-iqk1yiw4	380	12	(	(	-LRB-
cord-307860-iqk1yiw4	380	13	DUB	DUB	NNP
cord-307860-iqk1yiw4	380	14	/	/	SYM
cord-307860-iqk1yiw4	380	15	deISG	deISG	NNP
cord-307860-iqk1yiw4	380	16	)	)	-RRB-
cord-307860-iqk1yiw4	381	1	nsp3	nsp3	NNS
cord-307860-iqk1yiw4	381	2	deficient	deficient	JJ
cord-307860-iqk1yiw4	381	3	mutants	mutant	NNS
cord-307860-iqk1yiw4	381	4	(	(	-LRB-
cord-307860-iqk1yiw4	382	1	H1652R	H1652R	NNP
cord-307860-iqk1yiw4	382	2	,	,	,
cord-307860-iqk1yiw4	383	1	V1691	v1691	NN
cord-307860-iqk1yiw4	383	2	K	K	NNP
cord-307860-iqk1yiw4	383	3	,	,	,
cord-307860-iqk1yiw4	383	4	and	and	CC
cord-307860-iqk1yiw4	383	5	V1691R	V1691R	NNP
cord-307860-iqk1yiw4	383	6	)	)	-RRB-
cord-307860-iqk1yiw4	383	7	result	result	VBP
cord-307860-iqk1yiw4	383	8	in	in	IN
cord-307860-iqk1yiw4	383	9	attenuating	attenuate	VBG
cord-307860-iqk1yiw4	383	10	the	the	DT
cord-307860-iqk1yiw4	383	11	MERS	MERS	NNP
cord-307860-iqk1yiw4	383	12	virus	virus	NN
cord-307860-iqk1yiw4	383	13	[	[	-LRB-
cord-307860-iqk1yiw4	383	14	135	135	CD
cord-307860-iqk1yiw4	383	15	]	]	-RRB-
cord-307860-iqk1yiw4	383	16	.	.	.
cord-307860-iqk1yiw4	384	1	A	a	DT
cord-307860-iqk1yiw4	384	2	recent	recent	JJ
cord-307860-iqk1yiw4	384	3	study	study	NN
cord-307860-iqk1yiw4	384	4	identified	identify	VBD
cord-307860-iqk1yiw4	384	5	specific	specific	JJ
cord-307860-iqk1yiw4	384	6	mutations	mutation	NNS
cord-307860-iqk1yiw4	384	7	in	in	IN
cord-307860-iqk1yiw4	384	8	nsp3	nsp3	NNS
cord-307860-iqk1yiw4	384	9	corroborated	corroborate	VBN
cord-307860-iqk1yiw4	384	10	with	with	IN
cord-307860-iqk1yiw4	384	11	nsp2	nsp2	NN
cord-307860-iqk1yiw4	384	12	that	that	WDT
cord-307860-iqk1yiw4	384	13	suggest	suggest	VBP
cord-307860-iqk1yiw4	384	14	potential	potential	JJ
cord-307860-iqk1yiw4	384	15	mechanisms	mechanism	NNS
cord-307860-iqk1yiw4	384	16	that	that	WDT
cord-307860-iqk1yiw4	384	17	explain	explain	VBP
cord-307860-iqk1yiw4	384	18	higher	high	JJR
cord-307860-iqk1yiw4	384	19	contagiousness	contagiousness	NN
cord-307860-iqk1yiw4	384	20	of	of	IN
cord-307860-iqk1yiw4	384	21	SARS	SARS	NNP
cord-307860-iqk1yiw4	384	22	-	-	HYPH
cord-307860-iqk1yiw4	384	23	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	384	24	compared	compare	VBN
cord-307860-iqk1yiw4	384	25	to	to	IN
cord-307860-iqk1yiw4	384	26	SARS	SARS	NNP
cord-307860-iqk1yiw4	384	27	-	-	HYPH
cord-307860-iqk1yiw4	384	28	CoV	CoV	NNP
cord-307860-iqk1yiw4	384	29	[	[	-LRB-
cord-307860-iqk1yiw4	384	30	136	136	CD
cord-307860-iqk1yiw4	384	31	]	]	-RRB-
cord-307860-iqk1yiw4	384	32	.	.	.
cord-307860-iqk1yiw4	385	1	Thoms	Thoms	NNP
cord-307860-iqk1yiw4	385	2	 	 	_SP
cord-307860-iqk1yiw4	386	1	The	the	DT
cord-307860-iqk1yiw4	386	2	organization	organization	NN
cord-307860-iqk1yiw4	386	3	of	of	IN
cord-307860-iqk1yiw4	386	4	the	the	DT
cord-307860-iqk1yiw4	386	5	non	non	JJ
cord-307860-iqk1yiw4	386	6	-	-	JJ
cord-307860-iqk1yiw4	386	7	structural	structural	JJ
cord-307860-iqk1yiw4	386	8	(	(	-LRB-
cord-307860-iqk1yiw4	386	9	nsp	nsp	NN
cord-307860-iqk1yiw4	386	10	)	)	-RRB-
cord-307860-iqk1yiw4	386	11	proteins	protein	NNS
cord-307860-iqk1yiw4	386	12	in	in	IN
cord-307860-iqk1yiw4	386	13	CoV	cov	NN
cord-307860-iqk1yiw4	386	14	is	be	VBZ
cord-307860-iqk1yiw4	386	15	not	not	RB
cord-307860-iqk1yiw4	386	16	fully	fully	RB
cord-307860-iqk1yiw4	386	17	understood	understand	VBN
cord-307860-iqk1yiw4	386	18	.	.	.
cord-307860-iqk1yiw4	387	1	The	the	DT
cord-307860-iqk1yiw4	387	2	CoV	cov	NN
cord-307860-iqk1yiw4	387	3	has	have	VBZ
cord-307860-iqk1yiw4	387	4	two	two	CD
cord-307860-iqk1yiw4	387	5	overlapping	overlap	VBG
cord-307860-iqk1yiw4	387	6	open	open	JJ
cord-307860-iqk1yiw4	387	7	reading	reading	NN
cord-307860-iqk1yiw4	387	8	frames	frame	NNS
cord-307860-iqk1yiw4	387	9	(	(	-LRB-
cord-307860-iqk1yiw4	387	10	ORFs	ORFs	NNP
cord-307860-iqk1yiw4	387	11	)	)	-RRB-
cord-307860-iqk1yiw4	388	1	ORF	ORF	NNP
cord-307860-iqk1yiw4	388	2	1a	1a	CD
cord-307860-iqk1yiw4	388	3	and	and	CC
cord-307860-iqk1yiw4	388	4	ORF	ORF	NNP
cord-307860-iqk1yiw4	388	5	1b	1b	CD
cord-307860-iqk1yiw4	388	6	,	,	,
cord-307860-iqk1yiw4	388	7	and	and	CC
cord-307860-iqk1yiw4	388	8	by	by	IN
cord-307860-iqk1yiw4	388	9	1	1	CD
cord-307860-iqk1yiw4	388	10	ribosomal	ribosomal	JJ
cord-307860-iqk1yiw4	388	11	frameshifting	frameshifte	VBG
cord-307860-iqk1yiw4	388	12	-	-	:
cord-307860-iqk1yiw4	388	13	a	a	DT
cord-307860-iqk1yiw4	388	14	translational	translational	JJ
cord-307860-iqk1yiw4	388	15	regulation	regulation	NN
cord-307860-iqk1yiw4	388	16	mechanism	mechanism	NN
cord-307860-iqk1yiw4	388	17	described	describe	VBN
cord-307860-iqk1yiw4	388	18	in	in	IN
cord-307860-iqk1yiw4	388	19	retroviruses	retrovirus	NNS
cord-307860-iqk1yiw4	388	20	-	-	:
cord-307860-iqk1yiw4	388	21	there	there	EX
cord-307860-iqk1yiw4	388	22	is	be	VBZ
cord-307860-iqk1yiw4	388	23	a	a	DT
cord-307860-iqk1yiw4	388	24	regulation	regulation	NN
cord-307860-iqk1yiw4	388	25	of	of	IN
cord-307860-iqk1yiw4	388	26	relative	relative	JJ
cord-307860-iqk1yiw4	388	27	ratio	ratio	NN
cord-307860-iqk1yiw4	388	28	of	of	IN
cord-307860-iqk1yiw4	388	29	structural	structural	JJ
cord-307860-iqk1yiw4	388	30	to	to	IN
cord-307860-iqk1yiw4	388	31	enzymatic	enzymatic	JJ
cord-307860-iqk1yiw4	388	32	proteins	protein	NNS
cord-307860-iqk1yiw4	388	33	[	[	-LRB-
cord-307860-iqk1yiw4	388	34	137	137	CD
cord-307860-iqk1yiw4	388	35	,	,	,
cord-307860-iqk1yiw4	388	36	138	138	CD
cord-307860-iqk1yiw4	388	37	]	]	-RRB-
cord-307860-iqk1yiw4	388	38	.	.	.
cord-307860-iqk1yiw4	389	1	The	the	DT
cord-307860-iqk1yiw4	389	2	CoV	cov	NN
cord-307860-iqk1yiw4	389	3	synthesizes	synthesize	VBZ
cord-307860-iqk1yiw4	389	4	two	two	CD
cord-307860-iqk1yiw4	389	5	polyproteins	polyprotein	NNS
cord-307860-iqk1yiw4	389	6	that	that	WDT
cord-307860-iqk1yiw4	389	7	are	be	VBP
cord-307860-iqk1yiw4	389	8	further	further	RB
cord-307860-iqk1yiw4	389	9	cleaved	cleave	VBN
cord-307860-iqk1yiw4	389	10	by	by	IN
cord-307860-iqk1yiw4	389	11	the	the	DT
cord-307860-iqk1yiw4	389	12	viral	viral	JJ
cord-307860-iqk1yiw4	389	13	proteases	protease	NNS
cord-307860-iqk1yiw4	389	14	.	.	.
cord-307860-iqk1yiw4	390	1	The	the	DT
cord-307860-iqk1yiw4	390	2	replicase	replicase	NN
cord-307860-iqk1yiw4	390	3	polyprotein	polyprotein	NNP
cord-307860-iqk1yiw4	390	4	1ab	1ab	NNP
cord-307860-iqk1yiw4	390	5	(	(	-LRB-
cord-307860-iqk1yiw4	390	6	Uni	Uni	NNP
cord-307860-iqk1yiw4	390	7	-	-	HYPH
cord-307860-iqk1yiw4	390	8	ProtKB	ProtKB	NNP
cord-307860-iqk1yiw4	390	9	P0DTD1	P0DTD1	NNS
cord-307860-iqk1yiw4	390	10	)	)	-RRB-
cord-307860-iqk1yiw4	390	11	also	also	RB
cord-307860-iqk1yiw4	390	12	contains	contain	VBZ
cord-307860-iqk1yiw4	390	13	the	the	DT
cord-307860-iqk1yiw4	390	14	proteases	protease	NNS
cord-307860-iqk1yiw4	390	15	responsible	responsible	JJ
cord-307860-iqk1yiw4	390	16	for	for	IN
cord-307860-iqk1yiw4	390	17	the	the	DT
cord-307860-iqk1yiw4	390	18	cleavage	cleavage	NN
cord-307860-iqk1yiw4	390	19	[	[	-LRB-
cord-307860-iqk1yiw4	390	20	139	139	CD
cord-307860-iqk1yiw4	390	21	]	]	-RRB-
cord-307860-iqk1yiw4	390	22	.	.	.
cord-307860-iqk1yiw4	391	1	The	the	DT
cord-307860-iqk1yiw4	391	2	viral	viral	JJ
cord-307860-iqk1yiw4	391	3	protease	protease	NN
cord-307860-iqk1yiw4	391	4	3CL	3cl	CD
cord-307860-iqk1yiw4	391	5	pro	pro	NNP
cord-307860-iqk1yiw4	391	6	is	be	VBZ
cord-307860-iqk1yiw4	391	7	extensively	extensively	RB
cord-307860-iqk1yiw4	391	8	studied	study	VBN
cord-307860-iqk1yiw4	391	9	for	for	IN
cord-307860-iqk1yiw4	391	10	the	the	DT
cord-307860-iqk1yiw4	391	11	designing	designing	NN
cord-307860-iqk1yiw4	391	12	of	of	IN
cord-307860-iqk1yiw4	391	13	new	new	JJ
cord-307860-iqk1yiw4	391	14	drugs	drug	NNS
cord-307860-iqk1yiw4	391	15	to	to	TO
cord-307860-iqk1yiw4	391	16	control	control	VB
cord-307860-iqk1yiw4	391	17	the	the	DT
cord-307860-iqk1yiw4	391	18	spread	spread	NN
cord-307860-iqk1yiw4	391	19	of	of	IN
cord-307860-iqk1yiw4	391	20	human	human	JJ
cord-307860-iqk1yiw4	391	21	and	and	CC
cord-307860-iqk1yiw4	391	22	zoonotic	zoonotic	JJ
cord-307860-iqk1yiw4	391	23	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	391	24	[	[	-LRB-
cord-307860-iqk1yiw4	391	25	140	140	CD
cord-307860-iqk1yiw4	391	26	]	]	-RRB-
cord-307860-iqk1yiw4	391	27	.	.	.
cord-307860-iqk1yiw4	392	1	The	the	DT
cord-307860-iqk1yiw4	392	2	nsp9	nsp9	NN
cord-307860-iqk1yiw4	392	3	is	be	VBZ
cord-307860-iqk1yiw4	392	4	an	an	DT
cord-307860-iqk1yiw4	392	5	RNA	RNA	NNP
cord-307860-iqk1yiw4	392	6	-	-	HYPH
cord-307860-iqk1yiw4	392	7	replicase	replicase	NN
cord-307860-iqk1yiw4	392	8	which	which	WDT
cord-307860-iqk1yiw4	392	9	binds	bind	VBZ
cord-307860-iqk1yiw4	392	10	the	the	DT
cord-307860-iqk1yiw4	392	11	viral	viral	JJ
cord-307860-iqk1yiw4	392	12	RNA	RNA	NNP
cord-307860-iqk1yiw4	392	13	and	and	CC
cord-307860-iqk1yiw4	392	14	has	have	VBZ
cord-307860-iqk1yiw4	392	15	a	a	DT
cord-307860-iqk1yiw4	392	16	regulatory	regulatory	JJ
cord-307860-iqk1yiw4	392	17	effect	effect	NN
cord-307860-iqk1yiw4	392	18	in	in	IN
cord-307860-iqk1yiw4	392	19	viral	viral	JJ
cord-307860-iqk1yiw4	392	20	replication	replication	NN
cord-307860-iqk1yiw4	392	21	[	[	-LRB-
cord-307860-iqk1yiw4	392	22	141	141	CD
cord-307860-iqk1yiw4	392	23	]	]	-RRB-
cord-307860-iqk1yiw4	392	24	.	.	.
cord-307860-iqk1yiw4	393	1	Three	three	CD
cord-307860-iqk1yiw4	393	2	unpublished	unpublished	JJ
cord-307860-iqk1yiw4	393	3	crystal	crystal	NN
cord-307860-iqk1yiw4	393	4	structures	structure	NNS
cord-307860-iqk1yiw4	393	5	of	of	IN
cord-307860-iqk1yiw4	393	6	nsp9	nsp9	DT
cord-307860-iqk1yiw4	393	7	from	from	IN
cord-307860-iqk1yiw4	393	8	SARS	SARS	NNP
cord-307860-iqk1yiw4	393	9	-	-	HYPH
cord-307860-iqk1yiw4	393	10	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	393	11	were	be	VBD
cord-307860-iqk1yiw4	393	12	retrieved	retrieve	VBN
cord-307860-iqk1yiw4	393	13	from	from	IN
cord-307860-iqk1yiw4	393	14	the	the	DT
cord-307860-iqk1yiw4	393	15	PDB	PDB	NNP
cord-307860-iqk1yiw4	393	16	(	(	-LRB-
cord-307860-iqk1yiw4	393	17	PDB	PDB	NNP
cord-307860-iqk1yiw4	393	18	ID(s	ID(s	NNP
cord-307860-iqk1yiw4	393	19	)	)	-RRB-
cord-307860-iqk1yiw4	393	20	6W9Q	6w9q	CD
cord-307860-iqk1yiw4	393	21	,	,	,
cord-307860-iqk1yiw4	393	22	6W4B	6w4b	CD
cord-307860-iqk1yiw4	393	23	,	,	,
cord-307860-iqk1yiw4	393	24	and	and	CC
cord-307860-iqk1yiw4	393	25	6WXD	6wxd	CD
cord-307860-iqk1yiw4	393	26	)	)	-RRB-
cord-307860-iqk1yiw4	394	1	(	(	-LRB-
cord-307860-iqk1yiw4	394	2	Litter	Litter	NNP
cord-307860-iqk1yiw4	394	3	et	et	FW
cord-307860-iqk1yiw4	394	4	al	al	NNP
cord-307860-iqk1yiw4	394	5	.	.	.
cord-307860-iqk1yiw4	395	1	,	,	,
cord-307860-iqk1yiw4	396	1	and	and	CC
cord-307860-iqk1yiw4	396	2	Tan	Tan	NNP
cord-307860-iqk1yiw4	396	3	et	et	FW
cord-307860-iqk1yiw4	396	4	al	al	NNP
cord-307860-iqk1yiw4	396	5	.	.	.
cord-307860-iqk1yiw4	396	6	)	)	-RRB-
cord-307860-iqk1yiw4	396	7	.	.	.
cord-307860-iqk1yiw4	397	1	Previous	previous	JJ
cord-307860-iqk1yiw4	397	2	studies	study	NNS
cord-307860-iqk1yiw4	397	3	focused	focus	VBD
cord-307860-iqk1yiw4	397	4	on	on	IN
cord-307860-iqk1yiw4	397	5	nsp9	nsp9	DT
cord-307860-iqk1yiw4	397	6	from	from	IN
cord-307860-iqk1yiw4	397	7	other	other	JJ
cord-307860-iqk1yiw4	397	8	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	397	9	,	,	,
cord-307860-iqk1yiw4	397	10	demonstrated	demonstrate	VBD
cord-307860-iqk1yiw4	397	11	that	that	IN
cord-307860-iqk1yiw4	397	12	the	the	DT
cord-307860-iqk1yiw4	397	13	residues	residue	NNS
cord-307860-iqk1yiw4	397	14	from	from	IN
cord-307860-iqk1yiw4	397	15	the	the	DT
cord-307860-iqk1yiw4	397	16	dimer	dimer	NN
cord-307860-iqk1yiw4	397	17	interface	interface	NN
cord-307860-iqk1yiw4	397	18	greatly	greatly	RB
cord-307860-iqk1yiw4	397	19	influence	influence	VBP
cord-307860-iqk1yiw4	397	20	their	-PRON-	PRP$
cord-307860-iqk1yiw4	397	21	nucleic	nucleic	JJ
cord-307860-iqk1yiw4	397	22	acid	acid	NN
cord-307860-iqk1yiw4	397	23	binding	bind	VBG
cord-307860-iqk1yiw4	397	24	affinity	affinity	NN
cord-307860-iqk1yiw4	397	25	[	[	-LRB-
cord-307860-iqk1yiw4	397	26	142	142	CD
cord-307860-iqk1yiw4	397	27	]	]	-RRB-
cord-307860-iqk1yiw4	397	28	.	.	.
cord-307860-iqk1yiw4	398	1	According	accord	VBG
cord-307860-iqk1yiw4	398	2	to	to	IN
cord-307860-iqk1yiw4	398	3	Zeng	Zeng	NNP
cord-307860-iqk1yiw4	398	4	et	et	FW
cord-307860-iqk1yiw4	398	5	al	al	NNP
cord-307860-iqk1yiw4	398	6	.	.	.
cord-307860-iqk1yiw4	399	1	findings	finding	NNS
cord-307860-iqk1yiw4	399	2	,	,	,
cord-307860-iqk1yiw4	399	3	the	the	DT
cord-307860-iqk1yiw4	399	4	dimerization	dimerization	NN
cord-307860-iqk1yiw4	399	5	greatly	greatly	RB
cord-307860-iqk1yiw4	399	6	depends	depend	VBZ
cord-307860-iqk1yiw4	399	7	on	on	IN
cord-307860-iqk1yiw4	399	8	the	the	DT
cord-307860-iqk1yiw4	399	9	N	n	NN
cord-307860-iqk1yiw4	399	10	-	-	HYPH
cord-307860-iqk1yiw4	399	11	finger	finger	NN
cord-307860-iqk1yiw4	399	12	and	and	CC
cord-307860-iqk1yiw4	399	13	the	the	DT
cord-307860-iqk1yiw4	399	14	two	two	CD
cord-307860-iqk1yiw4	399	15	glycine	glycine	NN
cord-307860-iqk1yiw4	399	16	residues	residue	NNS
cord-307860-iqk1yiw4	399	17	from	from	IN
cord-307860-iqk1yiw4	399	18	a	a	DT
cord-307860-iqk1yiw4	399	19	conserved	conserve	VBN
cord-307860-iqk1yiw4	399	20	region	region	NN
cord-307860-iqk1yiw4	399	21	GXXXG	GXXXG	NNP
cord-307860-iqk1yiw4	399	22	[	[	-LRB-
cord-307860-iqk1yiw4	399	23	142	142	CD
cord-307860-iqk1yiw4	399	24	]	]	-RRB-
cord-307860-iqk1yiw4	399	25	.	.	.
cord-307860-iqk1yiw4	400	1	(	(	-LRB-
cord-307860-iqk1yiw4	400	2	Fig	Fig	NNP
cord-307860-iqk1yiw4	400	3	.	.	.
cord-307860-iqk1yiw4	400	4	10	10	CD
cord-307860-iqk1yiw4	400	5	)	)	-RRB-
cord-307860-iqk1yiw4	400	6	.	.	.
cord-307860-iqk1yiw4	401	1	The	the	DT
cord-307860-iqk1yiw4	401	2	nsp15	nsp15	NNP
cord-307860-iqk1yiw4	401	3	is	be	VBZ
cord-307860-iqk1yiw4	401	4	uridylate	uridylate	JJ
cord-307860-iqk1yiw4	401	5	-	-	HYPH
cord-307860-iqk1yiw4	401	6	specific	specific	JJ
cord-307860-iqk1yiw4	401	7	endoribonulcease	endoribonulcease	NN
cord-307860-iqk1yiw4	401	8	(	(	-LRB-
cord-307860-iqk1yiw4	401	9	Nen	Nen	NNP
cord-307860-iqk1yiw4	401	10	-	-	HYPH
cord-307860-iqk1yiw4	401	11	doU	doU	NNP
cord-307860-iqk1yiw4	401	12	)	)	-RRB-
cord-307860-iqk1yiw4	401	13	(	(	-LRB-
cord-307860-iqk1yiw4	401	14	E.C.	E.C.	NNP
cord-307860-iqk1yiw4	401	15	3.1.-.-	3.1.-.-	CD
cord-307860-iqk1yiw4	401	16	)	)	-RRB-
cord-307860-iqk1yiw4	401	17	highly	highly	RB
cord-307860-iqk1yiw4	401	18	conserved	conserve	VBN
cord-307860-iqk1yiw4	401	19	among	among	IN
cord-307860-iqk1yiw4	401	20	vertebrates	vertebrate	NNS
cord-307860-iqk1yiw4	401	21	coronaviruses	coronaviruse	NNS
cord-307860-iqk1yiw4	401	22	.	.	.
cord-307860-iqk1yiw4	402	1	The	the	DT
cord-307860-iqk1yiw4	402	2	nsp15	nsp15	NNP
cord-307860-iqk1yiw4	402	3	plays	play	VBZ
cord-307860-iqk1yiw4	402	4	an	an	DT
cord-307860-iqk1yiw4	402	5	important	important	JJ
cord-307860-iqk1yiw4	402	6	role	role	NN
cord-307860-iqk1yiw4	402	7	in	in	IN
cord-307860-iqk1yiw4	402	8	the	the	DT
cord-307860-iqk1yiw4	402	9	life	life	NN
cord-307860-iqk1yiw4	402	10	cycle	cycle	NN
cord-307860-iqk1yiw4	402	11	of	of	IN
cord-307860-iqk1yiw4	402	12	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	402	13	[	[	-LRB-
cord-307860-iqk1yiw4	402	14	143	143	CD
cord-307860-iqk1yiw4	402	15	,	,	,
cord-307860-iqk1yiw4	402	16	144	144	CD
cord-307860-iqk1yiw4	402	17	]	]	-RRB-
cord-307860-iqk1yiw4	402	18	.	.	.
cord-307860-iqk1yiw4	403	1	The	the	DT
cord-307860-iqk1yiw4	403	2	recent	recent	JJ
cord-307860-iqk1yiw4	403	3	SARS	SARS	NNP
cord-307860-iqk1yiw4	403	4	-	-	HYPH
cord-307860-iqk1yiw4	403	5	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	404	1	nsp15	nsp15	NNP
cord-307860-iqk1yiw4	404	2	structures	structure	NNS
cord-307860-iqk1yiw4	404	3	show	show	VBP
cord-307860-iqk1yiw4	404	4	that	that	IN
cord-307860-iqk1yiw4	404	5	it	-PRON-	PRP
cord-307860-iqk1yiw4	404	6	is	be	VBZ
cord-307860-iqk1yiw4	404	7	a	a	DT
cord-307860-iqk1yiw4	404	8	hexamer	hexamer	NN
cord-307860-iqk1yiw4	404	9	and	and	CC
cord-307860-iqk1yiw4	404	10	the	the	DT
cord-307860-iqk1yiw4	404	11	catalytic	catalytic	JJ
cord-307860-iqk1yiw4	404	12	site	site	NN
cord-307860-iqk1yiw4	404	13	belong	belong	VBP
cord-307860-iqk1yiw4	404	14	to	to	IN
cord-307860-iqk1yiw4	404	15	the	the	DT
cord-307860-iqk1yiw4	404	16	C	C	NNP
cord-307860-iqk1yiw4	404	17	-	-	HYPH
cord-307860-iqk1yiw4	404	18	terminal	terminal	NN
cord-307860-iqk1yiw4	404	19	domain	domain	NN
cord-307860-iqk1yiw4	404	20	(	(	-LRB-
cord-307860-iqk1yiw4	404	21	PDB	PDB	NNP
cord-307860-iqk1yiw4	404	22	ID(s	ID(s	NNP
cord-307860-iqk1yiw4	404	23	)	)	-RRB-
cord-307860-iqk1yiw4	405	1	6W01	6w01	CD
cord-307860-iqk1yiw4	405	2	and	and	CC
cord-307860-iqk1yiw4	405	3	6VWW	6VWW	NNP
cord-307860-iqk1yiw4	405	4	)	)	-RRB-
cord-307860-iqk1yiw4	406	1	.	.	.
cord-307860-iqk1yiw4	407	1	The	the	DT
cord-307860-iqk1yiw4	407	2	study	study	NN
cord-307860-iqk1yiw4	407	3	concludes	conclude	VBZ
cord-307860-iqk1yiw4	407	4	that	that	IN
cord-307860-iqk1yiw4	407	5	the	the	DT
cord-307860-iqk1yiw4	407	6	SARS	SARS	NNP
cord-307860-iqk1yiw4	407	7	-	-	HYPH
cord-307860-iqk1yiw4	407	8	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	407	9	nsp15	nsp15	PRP
cord-307860-iqk1yiw4	407	10	differs	differ	VBZ
cord-307860-iqk1yiw4	407	11	by	by	IN
cord-307860-iqk1yiw4	407	12	MERS	MERS	NNP
cord-307860-iqk1yiw4	407	13	-	-	HYPH
cord-307860-iqk1yiw4	407	14	CoV	CoV	NNP
cord-307860-iqk1yiw4	407	15	nsp15	nsp15	''
cord-307860-iqk1yiw4	407	16	by	by	IN
cord-307860-iqk1yiw4	407	17	residues	residue	NNS
cord-307860-iqk1yiw4	407	18	that	that	WDT
cord-307860-iqk1yiw4	407	19	coordinate	coordinate	VBP
cord-307860-iqk1yiw4	407	20	the	the	DT
cord-307860-iqk1yiw4	407	21	manganese	manganese	NN
cord-307860-iqk1yiw4	407	22	ion	ion	NN
cord-307860-iqk1yiw4	407	23	[	[	-LRB-
cord-307860-iqk1yiw4	407	24	145	145	CD
cord-307860-iqk1yiw4	407	25	]	]	-RRB-
cord-307860-iqk1yiw4	407	26	.	.	.
cord-307860-iqk1yiw4	408	1	The	the	DT
cord-307860-iqk1yiw4	408	2	SARS	SARS	NNP
cord-307860-iqk1yiw4	408	3	-	-	HYPH
cord-307860-iqk1yiw4	408	4	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	408	5	emerged	emerge	VBD
cord-307860-iqk1yiw4	408	6	at	at	IN
cord-307860-iqk1yiw4	408	7	the	the	DT
cord-307860-iqk1yiw4	408	8	late	late	JJ
cord-307860-iqk1yiw4	408	9	of	of	IN
cord-307860-iqk1yiw4	408	10	the	the	DT
cord-307860-iqk1yiw4	408	11	year	year	NN
cord-307860-iqk1yiw4	408	12	2019	2019	CD
cord-307860-iqk1yiw4	408	13	.	.	.
cord-307860-iqk1yiw4	409	1	The	the	DT
cord-307860-iqk1yiw4	409	2	epidemiology	epidemiology	NN
cord-307860-iqk1yiw4	409	3	of	of	IN
cord-307860-iqk1yiw4	409	4	COVID-19	covid-19	JJ
cord-307860-iqk1yiw4	409	5	pandemic	pandemic	NN
cord-307860-iqk1yiw4	409	6	is	be	VBZ
cord-307860-iqk1yiw4	409	7	beyond	beyond	IN
cord-307860-iqk1yiw4	409	8	the	the	DT
cord-307860-iqk1yiw4	409	9	subject	subject	NN
cord-307860-iqk1yiw4	409	10	of	of	IN
cord-307860-iqk1yiw4	409	11	this	this	DT
cord-307860-iqk1yiw4	409	12	paper	paper	NN
cord-307860-iqk1yiw4	409	13	.	.	.
cord-307860-iqk1yiw4	410	1	However	however	RB
cord-307860-iqk1yiw4	410	2	,	,	,
cord-307860-iqk1yiw4	410	3	we	-PRON-	PRP
cord-307860-iqk1yiw4	410	4	can	can	MD
cord-307860-iqk1yiw4	410	5	learn	learn	VB
cord-307860-iqk1yiw4	410	6	how	how	WRB
cord-307860-iqk1yiw4	410	7	other	other	JJ
cord-307860-iqk1yiw4	410	8	epidemics	epidemic	NNS
cord-307860-iqk1yiw4	410	9	have	have	VBP
cord-307860-iqk1yiw4	410	10	been	be	VBN
cord-307860-iqk1yiw4	410	11	handled	handle	VBN
cord-307860-iqk1yiw4	410	12	throughout	throughout	IN
cord-307860-iqk1yiw4	410	13	history	history	NN
cord-307860-iqk1yiw4	410	14	.	.	.
cord-307860-iqk1yiw4	411	1	There	there	EX
cord-307860-iqk1yiw4	411	2	are	be	VBP
cord-307860-iqk1yiw4	411	3	many	many	JJ
cord-307860-iqk1yiw4	411	4	historical	historical	JJ
cord-307860-iqk1yiw4	411	5	records	record	NNS
cord-307860-iqk1yiw4	411	6	,	,	,
cord-307860-iqk1yiw4	411	7	but	but	CC
cord-307860-iqk1yiw4	411	8	an	an	DT
cord-307860-iqk1yiw4	411	9	episode	episode	NN
cord-307860-iqk1yiw4	411	10	about	about	IN
cord-307860-iqk1yiw4	411	11	the	the	DT
cord-307860-iqk1yiw4	411	12	plaque	plaque	NN
cord-307860-iqk1yiw4	411	13	epidemic	epidemic	NN
cord-307860-iqk1yiw4	411	14	,	,	,
cord-307860-iqk1yiw4	411	15	brilliantly	brilliantly	RB
cord-307860-iqk1yiw4	411	16	described	describe	VBN
cord-307860-iqk1yiw4	411	17	by	by	IN
cord-307860-iqk1yiw4	411	18	Irving	Irving	NNP
cord-307860-iqk1yiw4	411	19	Stone	Stone	NNP
cord-307860-iqk1yiw4	411	20	in	in	IN
cord-307860-iqk1yiw4	411	21	The	the	DT
cord-307860-iqk1yiw4	411	22	Agony	Agony	NNP
cord-307860-iqk1yiw4	411	23	and	and	CC
cord-307860-iqk1yiw4	411	24	the	the	DT
cord-307860-iqk1yiw4	411	25	Ecstasy	Ecstasy	NNP
cord-307860-iqk1yiw4	411	26	,	,	,
cord-307860-iqk1yiw4	411	27	could	could	MD
cord-307860-iqk1yiw4	411	28	be	be	VB
cord-307860-iqk1yiw4	411	29	a	a	DT
cord-307860-iqk1yiw4	411	30	school	school	NN
cord-307860-iqk1yiw4	411	31	-	-	HYPH
cord-307860-iqk1yiw4	411	32	case	case	NN
cord-307860-iqk1yiw4	411	33	.	.	.
cord-307860-iqk1yiw4	412	1	In	in	IN
cord-307860-iqk1yiw4	412	2	the	the	DT
cord-307860-iqk1yiw4	412	3	Florence	Florence	NNP
cord-307860-iqk1yiw4	412	4	transformed	transform	VBD
cord-307860-iqk1yiw4	412	5	in	in	IN
cord-307860-iqk1yiw4	412	6	morgue	morgue	NN
cord-307860-iqk1yiw4	412	7	and	and	CC
cord-307860-iqk1yiw4	412	8	deserted	desert	VBN
cord-307860-iqk1yiw4	412	9	by	by	IN
cord-307860-iqk1yiw4	412	10	people	people	NNS
cord-307860-iqk1yiw4	412	11	,	,	,
cord-307860-iqk1yiw4	412	12	Michelangelo	Michelangelo	NNP
cord-307860-iqk1yiw4	412	13	-	-	HYPH
cord-307860-iqk1yiw4	412	14	Michelangelo	Michelangelo	NNP
cord-307860-iqk1yiw4	413	1	di	di	NNP
cord-307860-iqk1yiw4	413	2	Lodovico	Lodovico	NNP
cord-307860-iqk1yiw4	413	3	Buonarroti	Buonarroti	NNP
cord-307860-iqk1yiw4	413	4	Simoni	Simoni	NNP
cord-307860-iqk1yiw4	413	5	(	(	-LRB-
cord-307860-iqk1yiw4	413	6	1475	1475	CD
cord-307860-iqk1yiw4	413	7	-	-	SYM
cord-307860-iqk1yiw4	413	8	1564)-chose	1564)-chose	CD
cord-307860-iqk1yiw4	414	1	to	to	TO
cord-307860-iqk1yiw4	414	2	stay	stay	VB
cord-307860-iqk1yiw4	414	3	in	in	IN
cord-307860-iqk1yiw4	414	4	the	the	DT
cord-307860-iqk1yiw4	414	5	city	city	NN
cord-307860-iqk1yiw4	414	6	and	and	CC
cord-307860-iqk1yiw4	414	7	take	take	VB
cord-307860-iqk1yiw4	414	8	care	care	NN
cord-307860-iqk1yiw4	414	9	of	of	IN
cord-307860-iqk1yiw4	414	10	his	-PRON-	PRP$
cord-307860-iqk1yiw4	414	11	ill	ill	JJ
cord-307860-iqk1yiw4	414	12	younger	young	JJR
cord-307860-iqk1yiw4	414	13	brother	brother	NN
cord-307860-iqk1yiw4	414	14	until	until	IN
cord-307860-iqk1yiw4	414	15	the	the	DT
cord-307860-iqk1yiw4	414	16	last	last	JJ
cord-307860-iqk1yiw4	414	17	moment	moment	NN
cord-307860-iqk1yiw4	414	18	and	and	CC
cord-307860-iqk1yiw4	414	19	doing	do	VBG
cord-307860-iqk1yiw4	414	20	the	the	DT
cord-307860-iqk1yiw4	414	21	best	good	JJS
cord-307860-iqk1yiw4	414	22	for	for	IN
cord-307860-iqk1yiw4	414	23	a	a	DT
cord-307860-iqk1yiw4	414	24	decent	decent	JJ
cord-307860-iqk1yiw4	414	25	funeral	funeral	NN
cord-307860-iqk1yiw4	414	26	.	.	.
cord-307860-iqk1yiw4	415	1	Strikingly	strikingly	RB
cord-307860-iqk1yiw4	415	2	,	,	,
cord-307860-iqk1yiw4	415	3	in	in	IN
cord-307860-iqk1yiw4	415	4	the	the	DT
cord-307860-iqk1yiw4	415	5	XVI	XVI	NNP
cord-307860-iqk1yiw4	415	6	century	century	NN
cord-307860-iqk1yiw4	415	7	,	,	,
cord-307860-iqk1yiw4	415	8	Michelangelo	Michelangelo	NNP
cord-307860-iqk1yiw4	415	9	applied	apply	VBD
cord-307860-iqk1yiw4	415	10	the	the	DT
cord-307860-iqk1yiw4	415	11	recommendation	recommendation	NN
cord-307860-iqk1yiw4	415	12	for	for	IN
cord-307860-iqk1yiw4	415	13	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	415	14	-hygiene	-hygiene	JJ
cord-307860-iqk1yiw4	415	15	and	and	CC
cord-307860-iqk1yiw4	415	16	social	social	JJ
cord-307860-iqk1yiw4	415	17	distance	distance	NN
cord-307860-iqk1yiw4	415	18	.	.	.
cord-307860-iqk1yiw4	416	1	He	-PRON-	PRP
cord-307860-iqk1yiw4	416	2	thoroughly	thoroughly	RB
cord-307860-iqk1yiw4	416	3	brushed	brush	VBD
cord-307860-iqk1yiw4	416	4	himself	-PRON-	PRP
cord-307860-iqk1yiw4	416	5	into	into	IN
cord-307860-iqk1yiw4	416	6	a	a	DT
cord-307860-iqk1yiw4	416	7	bathtub	bathtub	NN
cord-307860-iqk1yiw4	416	8	with	with	IN
cord-307860-iqk1yiw4	416	9	hot	hot	JJ
cord-307860-iqk1yiw4	416	10	water	water	NN
cord-307860-iqk1yiw4	416	11	and	and	CC
cord-307860-iqk1yiw4	416	12	sent	send	VBD
cord-307860-iqk1yiw4	416	13	away	away	RB
cord-307860-iqk1yiw4	416	14	his	-PRON-	PRP$
cord-307860-iqk1yiw4	416	15	sister	sister	NN
cord-307860-iqk1yiw4	416	16	-	-	HYPH
cord-307860-iqk1yiw4	416	17	in	in	IN
cord-307860-iqk1yiw4	416	18	-	-	HYPH
cord-307860-iqk1yiw4	416	19	law	law	NN
cord-307860-iqk1yiw4	416	20	and	and	CC
cord-307860-iqk1yiw4	416	21	his	-PRON-	PRP$
cord-307860-iqk1yiw4	416	22	nephews	nephew	NNS
cord-307860-iqk1yiw4	416	23	.	.	.
cord-307860-iqk1yiw4	417	1	Even	even	RB
cord-307860-iqk1yiw4	417	2	he	-PRON-	PRP
cord-307860-iqk1yiw4	417	3	was	be	VBD
cord-307860-iqk1yiw4	417	4	asymptomatic	asymptomatic	JJ
cord-307860-iqk1yiw4	417	5	,	,	,
cord-307860-iqk1yiw4	417	6	in	in	IN
cord-307860-iqk1yiw4	417	7	our	-PRON-	PRP$
cord-307860-iqk1yiw4	417	8	days	day	NNS
cord-307860-iqk1yiw4	417	9	terms	term	NNS
cord-307860-iqk1yiw4	417	10	,	,	,
cord-307860-iqk1yiw4	417	11	he	-PRON-	PRP
cord-307860-iqk1yiw4	417	12	refused	refuse	VBD
cord-307860-iqk1yiw4	417	13	Granacci	Granacci	NNP
cord-307860-iqk1yiw4	417	14	's	's	POS
cord-307860-iqk1yiw4	417	15	wine	wine	NN
cord-307860-iqk1yiw4	417	16	.	.	.
cord-307860-iqk1yiw4	418	1	Unlike	unlike	IN
cord-307860-iqk1yiw4	418	2	the	the	DT
cord-307860-iqk1yiw4	418	3	plague	plague	NN
cord-307860-iqk1yiw4	418	4	described	describe	VBN
cord-307860-iqk1yiw4	418	5	by	by	IN
cord-307860-iqk1yiw4	418	6	Irving	Irving	NNP
cord-307860-iqk1yiw4	418	7	Stone	Stone	NNP
cord-307860-iqk1yiw4	418	8	,	,	,
cord-307860-iqk1yiw4	418	9	COVID-19	covid-19	JJ
cord-307860-iqk1yiw4	418	10	pandemic	pandemic	NN
cord-307860-iqk1yiw4	418	11	is	be	VBZ
cord-307860-iqk1yiw4	418	12	considerably	considerably	RB
cord-307860-iqk1yiw4	418	13	longer	long	JJR
cord-307860-iqk1yiw4	418	14	and	and	CC
cord-307860-iqk1yiw4	418	15	for	for	IN
cord-307860-iqk1yiw4	418	16	the	the	DT
cord-307860-iqk1yiw4	418	17	time	time	NN
cord-307860-iqk1yiw4	418	18	being	be	VBG
cord-307860-iqk1yiw4	418	19	there	there	EX
cord-307860-iqk1yiw4	418	20	is	be	VBZ
cord-307860-iqk1yiw4	418	21	no	no	DT
cord-307860-iqk1yiw4	418	22	hope	hope	NN
cord-307860-iqk1yiw4	418	23	for	for	IN
cord-307860-iqk1yiw4	418	24	its	-PRON-	PRP$
cord-307860-iqk1yiw4	418	25	end	end	NN
cord-307860-iqk1yiw4	418	26	soon	soon	RB
cord-307860-iqk1yiw4	418	27	.	.	.
cord-307860-iqk1yiw4	419	1	Until	until	IN
cord-307860-iqk1yiw4	419	2	the	the	DT
cord-307860-iqk1yiw4	419	3	emergence	emergence	NN
cord-307860-iqk1yiw4	419	4	of	of	IN
cord-307860-iqk1yiw4	419	5	SARS	SARS	NNP
cord-307860-iqk1yiw4	419	6	-	-	HYPH
cord-307860-iqk1yiw4	419	7	CoV	CoV	NNP
cord-307860-iqk1yiw4	419	8	in	in	IN
cord-307860-iqk1yiw4	419	9	2003	2003	CD
cord-307860-iqk1yiw4	419	10	and	and	CC
cord-307860-iqk1yiw4	419	11	MERS	MERS	NNPS
cord-307860-iqk1yiw4	419	12	in	in	IN
cord-307860-iqk1yiw4	419	13	2012	2012	CD
cord-307860-iqk1yiw4	419	14	,	,	,
cord-307860-iqk1yiw4	419	15	the	the	DT
cord-307860-iqk1yiw4	419	16	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	419	17	infections	infection	NNS
cord-307860-iqk1yiw4	419	18	do	do	VBP
cord-307860-iqk1yiw4	419	19	not	not	RB
cord-307860-iqk1yiw4	419	20	pay	pay	VB
cord-307860-iqk1yiw4	419	21	much	much	JJ
cord-307860-iqk1yiw4	419	22	attention	attention	NN
cord-307860-iqk1yiw4	419	23	.	.	.
cord-307860-iqk1yiw4	420	1	Now	now	RB
cord-307860-iqk1yiw4	420	2	,	,	,
cord-307860-iqk1yiw4	420	3	facing	face	VBG
cord-307860-iqk1yiw4	420	4	the	the	DT
cord-307860-iqk1yiw4	420	5	SARS	SARS	NNP
cord-307860-iqk1yiw4	420	6	-	-	HYPH
cord-307860-iqk1yiw4	420	7	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	420	8	,	,	,
cord-307860-iqk1yiw4	420	9	the	the	DT
cord-307860-iqk1yiw4	420	10	spectrum	spectrum	NN
cord-307860-iqk1yiw4	420	11	of	of	IN
cord-307860-iqk1yiw4	420	12	re	re	NN
cord-307860-iqk1yiw4	420	13	-	-	NN
cord-307860-iqk1yiw4	420	14	emergence	emergence	NN
cord-307860-iqk1yiw4	420	15	of	of	IN
cord-307860-iqk1yiw4	420	16	the	the	DT
cord-307860-iqk1yiw4	420	17	SARS	SARS	NNP
cord-307860-iqk1yiw4	420	18	-	-	HYPH
cord-307860-iqk1yiw4	420	19	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	420	20	or	or	CC
cord-307860-iqk1yiw4	420	21	the	the	DT
cord-307860-iqk1yiw4	420	22	animal	animal	NN
cord-307860-iqk1yiw4	420	23	-	-	HYPH
cord-307860-iqk1yiw4	420	24	human	human	JJ
cord-307860-iqk1yiw4	420	25	transmission	transmission	NN
cord-307860-iqk1yiw4	420	26	of	of	IN
cord-307860-iqk1yiw4	420	27	a	a	DT
cord-307860-iqk1yiw4	420	28	new	new	JJ
cord-307860-iqk1yiw4	420	29	CoV	cov	NN
cord-307860-iqk1yiw4	420	30	strain	strain	NN
cord-307860-iqk1yiw4	420	31	is	be	VBZ
cord-307860-iqk1yiw4	420	32	more	more	RBR
cord-307860-iqk1yiw4	420	33	real	real	JJ
cord-307860-iqk1yiw4	420	34	than	than	IN
cord-307860-iqk1yiw4	420	35	ever	ever	RB
cord-307860-iqk1yiw4	420	36	.	.	.
cord-307860-iqk1yiw4	421	1	So	so	RB
cord-307860-iqk1yiw4	421	2	,	,	,
cord-307860-iqk1yiw4	421	3	the	the	DT
cord-307860-iqk1yiw4	421	4	understanding	understanding	NN
cord-307860-iqk1yiw4	421	5	of	of	IN
cord-307860-iqk1yiw4	421	6	all	all	DT
cord-307860-iqk1yiw4	421	7	aspects	aspect	NNS
cord-307860-iqk1yiw4	421	8	of	of	IN
cord-307860-iqk1yiw4	421	9	the	the	DT
cord-307860-iqk1yiw4	421	10	SARS	SARS	NNP
cord-307860-iqk1yiw4	421	11	-	-	HYPH
cord-307860-iqk1yiw4	421	12	Cov-2	Cov-2	NNP
cord-307860-iqk1yiw4	421	13	is	be	VBZ
cord-307860-iqk1yiw4	421	14	of	of	IN
cord-307860-iqk1yiw4	421	15	great	great	JJ
cord-307860-iqk1yiw4	421	16	interest	interest	NN
cord-307860-iqk1yiw4	421	17	.	.	.
cord-307860-iqk1yiw4	422	1	The	the	DT
cord-307860-iqk1yiw4	422	2	rapid	rapid	JJ
cord-307860-iqk1yiw4	422	3	involvement	involvement	NN
cord-307860-iqk1yiw4	422	4	of	of	IN
cord-307860-iqk1yiw4	422	5	the	the	DT
cord-307860-iqk1yiw4	422	6	scientific	scientific	JJ
cord-307860-iqk1yiw4	422	7	communities	community	NNS
cord-307860-iqk1yiw4	422	8	greatly	greatly	RB
cord-307860-iqk1yiw4	422	9	advances	advance	VBZ
cord-307860-iqk1yiw4	422	10	the	the	DT
cord-307860-iqk1yiw4	422	11	elucidation	elucidation	NN
cord-307860-iqk1yiw4	422	12	of	of	IN
cord-307860-iqk1yiw4	422	13	some	some	DT
cord-307860-iqk1yiw4	422	14	aspects	aspect	NNS
cord-307860-iqk1yiw4	422	15	of	of	IN
cord-307860-iqk1yiw4	422	16	COVID-19	covid-19	JJ
cord-307860-iqk1yiw4	422	17	pandemic	pandemic	NN
cord-307860-iqk1yiw4	422	18	to	to	TO
cord-307860-iqk1yiw4	422	19	be	be	VB
cord-307860-iqk1yiw4	422	20	prepared	prepare	VBN
cord-307860-iqk1yiw4	422	21	in	in	IN
cord-307860-iqk1yiw4	422	22	the	the	DT
cord-307860-iqk1yiw4	422	23	event	event	NN
cord-307860-iqk1yiw4	422	24	of	of	IN
cord-307860-iqk1yiw4	422	25	a	a	DT
cord-307860-iqk1yiw4	422	26	new	new	JJ
cord-307860-iqk1yiw4	422	27	contagious	contagious	JJ
cord-307860-iqk1yiw4	422	28	and	and	CC
cord-307860-iqk1yiw4	422	29	fatal	fatal	JJ
cord-307860-iqk1yiw4	422	30	CoV	cov	NN
cord-307860-iqk1yiw4	422	31	disease	disease	NN
cord-307860-iqk1yiw4	422	32	.	.	.
cord-307860-iqk1yiw4	423	1	The	the	DT
cord-307860-iqk1yiw4	423	2	structural	structural	JJ
cord-307860-iqk1yiw4	423	3	studies	study	NNS
cord-307860-iqk1yiw4	423	4	focused	focus	VBD
cord-307860-iqk1yiw4	423	5	on	on	IN
cord-307860-iqk1yiw4	423	6	designing	design	VBG
cord-307860-iqk1yiw4	423	7	specific	specific	JJ
cord-307860-iqk1yiw4	423	8	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	423	9	to	to	TO
cord-307860-iqk1yiw4	423	10	gain	gain	VB
cord-307860-iqk1yiw4	423	11	knowledge	knowledge	NN
cord-307860-iqk1yiw4	423	12	about	about	IN
cord-307860-iqk1yiw4	423	13	the	the	DT
cord-307860-iqk1yiw4	423	14	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	423	15	treatment	treatment	NN
cord-307860-iqk1yiw4	423	16	,	,	,
cord-307860-iqk1yiw4	423	17	and	and	CC
cord-307860-iqk1yiw4	423	18	further	further	JJ
cord-307860-iqk1yiw4	423	19	studies	study	NNS
cord-307860-iqk1yiw4	423	20	involving	involve	VBG
cord-307860-iqk1yiw4	423	21	biophysical	biophysical	JJ
cord-307860-iqk1yiw4	423	22	methods	method	NNS
cord-307860-iqk1yiw4	423	23	will	will	MD
cord-307860-iqk1yiw4	423	24	speed	speed	VB
cord-307860-iqk1yiw4	423	25	up	up	RP
cord-307860-iqk1yiw4	423	26	the	the	DT
cord-307860-iqk1yiw4	423	27	SARS	SARS	NNP
cord-307860-iqk1yiw4	423	28	-	-	HYPH
cord-307860-iqk1yiw4	423	29	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	423	30	cure	cure	NN
cord-307860-iqk1yiw4	423	31	[	[	-LRB-
cord-307860-iqk1yiw4	423	32	146	146	CD
cord-307860-iqk1yiw4	423	33	,	,	,
cord-307860-iqk1yiw4	423	34	147	147	CD
cord-307860-iqk1yiw4	423	35	]	]	-RRB-
cord-307860-iqk1yiw4	423	36	.	.	.
cord-307860-iqk1yiw4	424	1	Likewise	likewise	RB
cord-307860-iqk1yiw4	424	2	,	,	,
cord-307860-iqk1yiw4	424	3	many	many	JJ
cord-307860-iqk1yiw4	424	4	research	research	NN
cord-307860-iqk1yiw4	424	5	teams	team	NNS
cord-307860-iqk1yiw4	424	6	advance	advance	VBP
cord-307860-iqk1yiw4	424	7	their	-PRON-	PRP$
cord-307860-iqk1yiw4	424	8	studies	study	NNS
cord-307860-iqk1yiw4	424	9	on	on	IN
cord-307860-iqk1yiw4	424	10	understanding	understand	VBG
cord-307860-iqk1yiw4	424	11	the	the	DT
cord-307860-iqk1yiw4	424	12	most	most	RBS
cord-307860-iqk1yiw4	424	13	subtle	subtle	JJ
cord-307860-iqk1yiw4	424	14	details	detail	NNS
cord-307860-iqk1yiw4	424	15	of	of	IN
cord-307860-iqk1yiw4	424	16	the	the	DT
cord-307860-iqk1yiw4	424	17	virus	virus	NN
cord-307860-iqk1yiw4	424	18	-	-	HYPH
cord-307860-iqk1yiw4	424	19	host	host	NN
cord-307860-iqk1yiw4	424	20	cell	cell	NN
cord-307860-iqk1yiw4	424	21	interaction	interaction	NN
cord-307860-iqk1yiw4	424	22	,	,	,
cord-307860-iqk1yiw4	424	23	the	the	DT
cord-307860-iqk1yiw4	424	24	emergence	emergence	NN
cord-307860-iqk1yiw4	424	25	of	of	IN
cord-307860-iqk1yiw4	424	26	the	the	DT
cord-307860-iqk1yiw4	424	27	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	424	28	antibodies	antibody	NNS
cord-307860-iqk1yiw4	424	29	,	,	,
cord-307860-iqk1yiw4	424	30	or	or	CC
cord-307860-iqk1yiw4	424	31	the	the	DT
cord-307860-iqk1yiw4	424	32	designing	designing	NN
cord-307860-iqk1yiw4	424	33	of	of	IN
cord-307860-iqk1yiw4	424	34	new	new	JJ
cord-307860-iqk1yiw4	424	35	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	424	36	.	.	.
cord-307860-iqk1yiw4	425	1	The	the	DT
cord-307860-iqk1yiw4	425	2	virus	virus	NN
cord-307860-iqk1yiw4	425	3	and	and	CC
cord-307860-iqk1yiw4	425	4	host	host	NN
cord-307860-iqk1yiw4	425	5	factors	factor	NNS
cord-307860-iqk1yiw4	425	6	are	be	VBP
cord-307860-iqk1yiw4	425	7	both	both	DT
cord-307860-iqk1yiw4	425	8	relevant	relevant	JJ
cord-307860-iqk1yiw4	425	9	for	for	IN
cord-307860-iqk1yiw4	425	10	the	the	DT
cord-307860-iqk1yiw4	425	11	initiation	initiation	NN
cord-307860-iqk1yiw4	425	12	and	and	CC
cord-307860-iqk1yiw4	425	13	evolution	evolution	NN
cord-307860-iqk1yiw4	425	14	of	of	IN
cord-307860-iqk1yiw4	425	15	a	a	DT
cord-307860-iqk1yiw4	425	16	viral	viral	JJ
cord-307860-iqk1yiw4	425	17	infection	infection	NN
cord-307860-iqk1yiw4	425	18	.	.	.
cord-307860-iqk1yiw4	426	1	The	the	DT
cord-307860-iqk1yiw4	426	2	SARS	SARS	NNP
cord-307860-iqk1yiw4	426	3	-	-	HYPH
cord-307860-iqk1yiw4	426	4	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	426	5	shares	share	VBZ
cord-307860-iqk1yiw4	426	6	epidemiological	epidemiological	JJ
cord-307860-iqk1yiw4	426	7	patterns	pattern	NNS
cord-307860-iqk1yiw4	426	8	with	with	IN
cord-307860-iqk1yiw4	426	9	SARS	SARS	NNP
cord-307860-iqk1yiw4	426	10	-	-	HYPH
cord-307860-iqk1yiw4	426	11	CoV	CoV	NNP
cord-307860-iqk1yiw4	426	12	and	and	CC
cord-307860-iqk1yiw4	426	13	MERS	MERS	NNP
cord-307860-iqk1yiw4	426	14	,	,	,
cord-307860-iqk1yiw4	426	15	but	but	CC
cord-307860-iqk1yiw4	426	16	there	there	EX
cord-307860-iqk1yiw4	426	17	are	be	VBP
cord-307860-iqk1yiw4	426	18	some	some	DT
cord-307860-iqk1yiw4	426	19	structural	structural	JJ
cord-307860-iqk1yiw4	426	20	differences	difference	NNS
cord-307860-iqk1yiw4	426	21	.	.	.
cord-307860-iqk1yiw4	427	1	Thus	thus	RB
cord-307860-iqk1yiw4	427	2	,	,	,
cord-307860-iqk1yiw4	427	3	even	even	RB
cord-307860-iqk1yiw4	427	4	though	though	IN
cord-307860-iqk1yiw4	427	5	SARS	SARS	NNP
cord-307860-iqk1yiw4	427	6	-	-	HYPH
cord-307860-iqk1yiw4	427	7	CoV	CoV	NNP
cord-307860-iqk1yiw4	427	8	and	and	CC
cord-307860-iqk1yiw4	427	9	SARS	SARS	NNP
cord-307860-iqk1yiw4	427	10	-	-	HYPH
cord-307860-iqk1yiw4	427	11	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	427	12	use	use	VB
cord-307860-iqk1yiw4	427	13	the	the	DT
cord-307860-iqk1yiw4	427	14	same	same	JJ
cord-307860-iqk1yiw4	427	15	host	host	NN
cord-307860-iqk1yiw4	427	16	receptor	receptor	NN
cord-307860-iqk1yiw4	427	17	,	,	,
cord-307860-iqk1yiw4	427	18	SARS	SARS	NNP
cord-307860-iqk1yiw4	427	19	-	-	HYPH
cord-307860-iqk1yiw4	427	20	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	427	21	binds	bind	VBZ
cord-307860-iqk1yiw4	427	22	to	to	IN
cord-307860-iqk1yiw4	427	23	the	the	DT
cord-307860-iqk1yiw4	427	24	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	427	25	with	with	IN
cord-307860-iqk1yiw4	427	26	higher	high	JJR
cord-307860-iqk1yiw4	427	27	affinity	affinity	NN
cord-307860-iqk1yiw4	427	28	[	[	-LRB-
cord-307860-iqk1yiw4	427	29	101	101	CD
cord-307860-iqk1yiw4	427	30	]	]	-RRB-
cord-307860-iqk1yiw4	427	31	.	.	.
cord-307860-iqk1yiw4	428	1	Two	two	CD
cord-307860-iqk1yiw4	428	2	main	main	JJ
cord-307860-iqk1yiw4	428	3	features	feature	NNS
cord-307860-iqk1yiw4	428	4	are	be	VBP
cord-307860-iqk1yiw4	428	5	associated	associate	VBN
cord-307860-iqk1yiw4	428	6	with	with	IN
cord-307860-iqk1yiw4	428	7	the	the	DT
cord-307860-iqk1yiw4	428	8	worst	bad	JJS
cord-307860-iqk1yiw4	428	9	outcome	outcome	NN
cord-307860-iqk1yiw4	428	10	in	in	IN
cord-307860-iqk1yiw4	428	11	SARS	SARS	NNP
cord-307860-iqk1yiw4	428	12	-	-	HYPH
cord-307860-iqk1yiw4	428	13	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	428	14	infection	infection	NN
cord-307860-iqk1yiw4	428	15	-	-	HYPH
cord-307860-iqk1yiw4	428	16	co	co	NNS
cord-307860-iqk1yiw4	428	17	-	-	NNS
cord-307860-iqk1yiw4	428	18	morbidities	morbidity	NNS
cord-307860-iqk1yiw4	428	19	and	and	CC
cord-307860-iqk1yiw4	428	20	elderly	elderly	JJ
cord-307860-iqk1yiw4	428	21	.	.	.
cord-307860-iqk1yiw4	429	1	The	the	DT
cord-307860-iqk1yiw4	429	2	traits	trait	NNS
cord-307860-iqk1yiw4	429	3	of	of	IN
cord-307860-iqk1yiw4	429	4	immune	immune	JJ
cord-307860-iqk1yiw4	429	5	system	system	NN
cord-307860-iqk1yiw4	429	6	at	at	IN
cord-307860-iqk1yiw4	429	7	different	different	JJ
cord-307860-iqk1yiw4	429	8	ages	age	NNS
cord-307860-iqk1yiw4	429	9	could	could	MD
cord-307860-iqk1yiw4	429	10	be	be	VB
cord-307860-iqk1yiw4	429	11	a	a	DT
cord-307860-iqk1yiw4	429	12	strong	strong	JJ
cord-307860-iqk1yiw4	429	13	explanation	explanation	NN
cord-307860-iqk1yiw4	429	14	about	about	IN
cord-307860-iqk1yiw4	429	15	the	the	DT
cord-307860-iqk1yiw4	429	16	accompanying	accompany	VBG
cord-307860-iqk1yiw4	429	17	symptoms	symptom	NNS
cord-307860-iqk1yiw4	429	18	of	of	IN
cord-307860-iqk1yiw4	429	19	various	various	JJ
cord-307860-iqk1yiw4	429	20	viruses	virus	NNS
cord-307860-iqk1yiw4	429	21	when	when	WRB
cord-307860-iqk1yiw4	429	22	they	-PRON-	PRP
cord-307860-iqk1yiw4	429	23	present	present	VBP
cord-307860-iqk1yiw4	429	24	with	with	IN
cord-307860-iqk1yiw4	429	25	an	an	DT
cord-307860-iqk1yiw4	429	26	underlying	underlie	VBG
cord-307860-iqk1yiw4	429	27	disease	disease	NN
cord-307860-iqk1yiw4	429	28	.	.	.
cord-307860-iqk1yiw4	430	1	For	for	IN
cord-307860-iqk1yiw4	430	2	example	example	NN
cord-307860-iqk1yiw4	430	3	,	,	,
cord-307860-iqk1yiw4	430	4	episodes	episode	NNS
cord-307860-iqk1yiw4	430	5	of	of	IN
cord-307860-iqk1yiw4	430	6	wheezing	wheeze	VBG
cord-307860-iqk1yiw4	430	7	in	in	IN
cord-307860-iqk1yiw4	430	8	young	young	JJ
cord-307860-iqk1yiw4	430	9	children	child	NNS
cord-307860-iqk1yiw4	430	10	have	have	VBP
cord-307860-iqk1yiw4	430	11	been	be	VBN
cord-307860-iqk1yiw4	430	12	observed	observe	VBN
cord-307860-iqk1yiw4	430	13	in	in	IN
cord-307860-iqk1yiw4	430	14	respiratory	respiratory	JJ
cord-307860-iqk1yiw4	430	15	syncytial	syncytial	JJ
cord-307860-iqk1yiw4	430	16	virus	virus	NN
cord-307860-iqk1yiw4	430	17	(	(	-LRB-
cord-307860-iqk1yiw4	430	18	RSV	RSV	NNP
cord-307860-iqk1yiw4	430	19	)	)	-RRB-
cord-307860-iqk1yiw4	430	20	infections	infection	NNS
cord-307860-iqk1yiw4	430	21	.	.	.
cord-307860-iqk1yiw4	431	1	In	in	IN
cord-307860-iqk1yiw4	431	2	contrast	contrast	NN
cord-307860-iqk1yiw4	431	3	,	,	,
cord-307860-iqk1yiw4	431	4	in	in	IN
cord-307860-iqk1yiw4	431	5	adults	adult	NNS
cord-307860-iqk1yiw4	431	6	and	and	CC
cord-307860-iqk1yiw4	431	7	older	old	JJR
cord-307860-iqk1yiw4	431	8	children	child	NNS
cord-307860-iqk1yiw4	431	9	,	,	,
cord-307860-iqk1yiw4	431	10	the	the	DT
cord-307860-iqk1yiw4	431	11	episodes	episode	NNS
cord-307860-iqk1yiw4	431	12	of	of	IN
cord-307860-iqk1yiw4	431	13	wheezing	wheeze	VBG
cord-307860-iqk1yiw4	431	14	have	have	VBP
cord-307860-iqk1yiw4	431	15	been	be	VBN
cord-307860-iqk1yiw4	431	16	observed	observe	VBN
cord-307860-iqk1yiw4	431	17	in	in	IN
cord-307860-iqk1yiw4	431	18	human	human	JJ
cord-307860-iqk1yiw4	431	19	rhinoviruses	rhinovirus	NNS
cord-307860-iqk1yiw4	431	20	(	(	-LRB-
cord-307860-iqk1yiw4	431	21	HRV	HRV	NNP
cord-307860-iqk1yiw4	431	22	)	)	-RRB-
cord-307860-iqk1yiw4	431	23	and	and	CC
cord-307860-iqk1yiw4	432	1	HCoVs	HCoVs	NNP
cord-307860-iqk1yiw4	432	2	(	(	-LRB-
cord-307860-iqk1yiw4	432	3	HCoV	HCoV	NNP
cord-307860-iqk1yiw4	432	4	-	-	HYPH
cord-307860-iqk1yiw4	432	5	NL63	NL63	NNP
cord-307860-iqk1yiw4	432	6	and	and	CC
cord-307860-iqk1yiw4	432	7	HCoV	HCoV	NNP
cord-307860-iqk1yiw4	432	8	-	-	HYPH
cord-307860-iqk1yiw4	432	9	HKU1	HKU1	NNP
cord-307860-iqk1yiw4	432	10	)	)	-RRB-
cord-307860-iqk1yiw4	432	11	infections	infection	NNS
cord-307860-iqk1yiw4	432	12	[	[	-LRB-
cord-307860-iqk1yiw4	432	13	148	148	CD
cord-307860-iqk1yiw4	432	14	]	]	-RRB-
cord-307860-iqk1yiw4	432	15	.	.	.
cord-307860-iqk1yiw4	433	1	Recent	recent	JJ
cord-307860-iqk1yiw4	433	2	studies	study	NNS
cord-307860-iqk1yiw4	433	3	identify	identify	VBP
cord-307860-iqk1yiw4	433	4	ACE-2	ACE-2	NNP
cord-307860-iqk1yiw4	433	5	maturation	maturation	NN
cord-307860-iqk1yiw4	433	6	stages	stage	NNS
cord-307860-iqk1yiw4	433	7	,	,	,
cord-307860-iqk1yiw4	433	8	and	and	CC
cord-307860-iqk1yiw4	433	9	the	the	DT
cord-307860-iqk1yiw4	433	10	hypertension	hypertension	NN
cord-307860-iqk1yiw4	433	11	treatment	treatment	NN
cord-307860-iqk1yiw4	433	12	with	with	IN
cord-307860-iqk1yiw4	433	13	ACE	ace	NN
cord-307860-iqk1yiw4	433	14	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	433	15	could	could	MD
cord-307860-iqk1yiw4	433	16	be	be	VB
cord-307860-iqk1yiw4	433	17	an	an	DT
cord-307860-iqk1yiw4	433	18	explanation	explanation	NN
cord-307860-iqk1yiw4	433	19	for	for	IN
cord-307860-iqk1yiw4	433	20	mild	mild	JJ
cord-307860-iqk1yiw4	433	21	disease	disease	NN
cord-307860-iqk1yiw4	433	22	in	in	IN
cord-307860-iqk1yiw4	433	23	children	child	NNS
cord-307860-iqk1yiw4	433	24	[	[	-LRB-
cord-307860-iqk1yiw4	433	25	149	149	CD
cord-307860-iqk1yiw4	433	26	,	,	,
cord-307860-iqk1yiw4	433	27	150	150	CD
cord-307860-iqk1yiw4	433	28	]	]	-RRB-
cord-307860-iqk1yiw4	433	29	.	.	.
cord-307860-iqk1yiw4	434	1	Thus	thus	RB
cord-307860-iqk1yiw4	434	2	,	,	,
cord-307860-iqk1yiw4	434	3	structural	structural	JJ
cord-307860-iqk1yiw4	434	4	studies	study	NNS
cord-307860-iqk1yiw4	434	5	about	about	IN
cord-307860-iqk1yiw4	434	6	spike	spike	NN
cord-307860-iqk1yiw4	434	7	-ACE-2	-ACE-2	,
cord-307860-iqk1yiw4	434	8	and	and	CC
cord-307860-iqk1yiw4	434	9	ACE2-neutralizing	ace2-neutralizing	NN
cord-307860-iqk1yiw4	434	10	antibodies	antibody	NNS
cord-307860-iqk1yiw4	434	11	are	be	VBP
cord-307860-iqk1yiw4	434	12	of	of	IN
cord-307860-iqk1yiw4	434	13	great	great	JJ
cord-307860-iqk1yiw4	434	14	interest	interest	NN
cord-307860-iqk1yiw4	434	15	.	.	.
cord-307860-iqk1yiw4	435	1	The	the	DT
cord-307860-iqk1yiw4	435	2	crystal	crystal	NN
cord-307860-iqk1yiw4	435	3	structures	structure	NNS
cord-307860-iqk1yiw4	435	4	of	of	IN
cord-307860-iqk1yiw4	435	5	SARS	SARS	NNP
cord-307860-iqk1yiw4	435	6	-	-	:
cord-307860-iqk1yiw4	435	7	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	435	8	reveal	reveal	VB
cord-307860-iqk1yiw4	435	9	important	important	JJ
cord-307860-iqk1yiw4	435	10	details	detail	NNS
cord-307860-iqk1yiw4	435	11	about	about	IN
cord-307860-iqk1yiw4	435	12	the	the	DT
cord-307860-iqk1yiw4	435	13	viral	viral	JJ
cord-307860-iqk1yiw4	435	14	infection	infection	NN
cord-307860-iqk1yiw4	435	15	.	.	.
cord-307860-iqk1yiw4	436	1	First	first	RB
cord-307860-iqk1yiw4	436	2	,	,	,
cord-307860-iqk1yiw4	436	3	the	the	DT
cord-307860-iqk1yiw4	436	4	full	full	JJ
cord-307860-iqk1yiw4	436	5	-	-	HYPH
cord-307860-iqk1yiw4	436	6	length	length	NN
cord-307860-iqk1yiw4	436	7	human	human	JJ
cord-307860-iqk1yiw4	436	8	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	436	9	structure	structure	NN
cord-307860-iqk1yiw4	436	10	reveals	reveal	VBZ
cord-307860-iqk1yiw4	436	11	that	that	IN
cord-307860-iqk1yiw4	436	12	viral	viral	JJ
cord-307860-iqk1yiw4	436	13	cell	cell	NN
cord-307860-iqk1yiw4	436	14	entry	entry	NN
cord-307860-iqk1yiw4	436	15	involves	involve	VBZ
cord-307860-iqk1yiw4	436	16	the	the	DT
cord-307860-iqk1yiw4	436	17	simultaneous	simultaneous	JJ
cord-307860-iqk1yiw4	436	18	binding	binding	NN
cord-307860-iqk1yiw4	436	19	of	of	IN
cord-307860-iqk1yiw4	436	20	two	two	CD
cord-307860-iqk1yiw4	436	21	S	s	NN
cord-307860-iqk1yiw4	436	22	glycoproteins	glycoprotein	NNS
cord-307860-iqk1yiw4	436	23	to	to	IN
cord-307860-iqk1yiw4	436	24	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	436	25	.	.	.
cord-307860-iqk1yiw4	437	1	Also	also	RB
cord-307860-iqk1yiw4	437	2	,	,	,
cord-307860-iqk1yiw4	437	3	the	the	DT
cord-307860-iqk1yiw4	437	4	use	use	NN
cord-307860-iqk1yiw4	437	5	of	of	IN
cord-307860-iqk1yiw4	437	6	B(0)AT1	b(0)at1	NN
cord-307860-iqk1yiw4	437	7	in	in	IN
cord-307860-iqk1yiw4	437	8	stabilization	stabilization	NN
cord-307860-iqk1yiw4	437	9	of	of	IN
cord-307860-iqk1yiw4	437	10	the	the	DT
cord-307860-iqk1yiw4	437	11	full	full	JJ
cord-307860-iqk1yiw4	437	12	-	-	HYPH
cord-307860-iqk1yiw4	437	13	length	length	NN
cord-307860-iqk1yiw4	437	14	human	human	JJ
cord-307860-iqk1yiw4	437	15	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	437	16	structure	structure	NN
cord-307860-iqk1yiw4	437	17	advances	advance	VBZ
cord-307860-iqk1yiw4	437	18	the	the	DT
cord-307860-iqk1yiw4	437	19	hypothesis	hypothesis	NN
cord-307860-iqk1yiw4	437	20	that	that	IN
cord-307860-iqk1yiw4	437	21	B(0)AT1	B(0)AT1	NNP
cord-307860-iqk1yiw4	437	22	may	may	MD
cord-307860-iqk1yiw4	437	23	play	play	VB
cord-307860-iqk1yiw4	437	24	a	a	DT
cord-307860-iqk1yiw4	437	25	role	role	NN
cord-307860-iqk1yiw4	437	26	in	in	IN
cord-307860-iqk1yiw4	437	27	enteric	enteric	JJ
cord-307860-iqk1yiw4	437	28	infections	infection	NNS
cord-307860-iqk1yiw4	437	29	of	of	IN
cord-307860-iqk1yiw4	437	30	some	some	DT
cord-307860-iqk1yiw4	437	31	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	437	32	[	[	-LRB-
cord-307860-iqk1yiw4	437	33	39	39	CD
cord-307860-iqk1yiw4	437	34	]	]	-RRB-
cord-307860-iqk1yiw4	437	35	.	.	.
cord-307860-iqk1yiw4	438	1	Certain	certain	JJ
cord-307860-iqk1yiw4	438	2	virus	virus	NN
cord-307860-iqk1yiw4	438	3	components	component	NNS
cord-307860-iqk1yiw4	438	4	trigger	trigger	VBP
cord-307860-iqk1yiw4	438	5	the	the	DT
cord-307860-iqk1yiw4	438	6	immune	immune	JJ
cord-307860-iqk1yiw4	438	7	system	system	NN
cord-307860-iqk1yiw4	438	8	and	and	CC
cord-307860-iqk1yiw4	438	9	limit	limit	VB
cord-307860-iqk1yiw4	438	10	the	the	DT
cord-307860-iqk1yiw4	438	11	interspecies	interspecie	NNS
cord-307860-iqk1yiw4	438	12	transmission	transmission	NN
cord-307860-iqk1yiw4	438	13	of	of	IN
cord-307860-iqk1yiw4	438	14	different	different	JJ
cord-307860-iqk1yiw4	438	15	CoVs	covs	NN
cord-307860-iqk1yiw4	438	16	.	.	.
cord-307860-iqk1yiw4	439	1	The	the	DT
cord-307860-iqk1yiw4	439	2	structural	structural	JJ
cord-307860-iqk1yiw4	439	3	studies	study	NNS
cord-307860-iqk1yiw4	439	4	greatly	greatly	RB
cord-307860-iqk1yiw4	439	5	advance	advance	VBP
cord-307860-iqk1yiw4	439	6	the	the	DT
cord-307860-iqk1yiw4	439	7	selection	selection	NN
cord-307860-iqk1yiw4	439	8	of	of	IN
cord-307860-iqk1yiw4	439	9	the	the	DT
cord-307860-iqk1yiw4	439	10	best	good	JJS
cord-307860-iqk1yiw4	439	11	immunogens	immunogen	NNS
cord-307860-iqk1yiw4	439	12	for	for	IN
cord-307860-iqk1yiw4	439	13	SARS	SARS	NNP
cord-307860-iqk1yiw4	439	14	-	-	HYPH
cord-307860-iqk1yiw4	439	15	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	439	16	prophylaxis	prophylaxis	NN
cord-307860-iqk1yiw4	439	17	.	.	.
cord-307860-iqk1yiw4	440	1	A	a	DT
cord-307860-iqk1yiw4	440	2	comparison	comparison	NN
cord-307860-iqk1yiw4	440	3	of	of	IN
cord-307860-iqk1yiw4	440	4	the	the	DT
cord-307860-iqk1yiw4	440	5	HCoV	HCoV	NNP
cord-307860-iqk1yiw4	440	6	suggests	suggest	VBZ
cord-307860-iqk1yiw4	440	7	that	that	IN
cord-307860-iqk1yiw4	440	8	the	the	DT
cord-307860-iqk1yiw4	440	9	spike	spike	NN
cord-307860-iqk1yiw4	440	10	's	's	POS
cord-307860-iqk1yiw4	440	11	SARS	SARS	NNP
cord-307860-iqk1yiw4	440	12	-	-	HYPH
cord-307860-iqk1yiw4	440	13	CoV-2-CTD	CoV-2-CTD	NNP
cord-307860-iqk1yiw4	440	14	domain	domain	NN
cord-307860-iqk1yiw4	440	15	could	could	MD
cord-307860-iqk1yiw4	440	16	be	be	VB
cord-307860-iqk1yiw4	440	17	a	a	DT
cord-307860-iqk1yiw4	440	18	valid	valid	JJ
cord-307860-iqk1yiw4	440	19	immunogen	immunogen	NN
cord-307860-iqk1yiw4	440	20	for	for	IN
cord-307860-iqk1yiw4	440	21	a	a	DT
cord-307860-iqk1yiw4	440	22	future	future	JJ
cord-307860-iqk1yiw4	440	23	vaccine	vaccine	NN
cord-307860-iqk1yiw4	440	24	[	[	-LRB-
cord-307860-iqk1yiw4	440	25	36	36	CD
cord-307860-iqk1yiw4	440	26	]	]	-RRB-
cord-307860-iqk1yiw4	440	27	.	.	.
cord-307860-iqk1yiw4	441	1	The	the	DT
cord-307860-iqk1yiw4	441	2	viral	viral	JJ
cord-307860-iqk1yiw4	441	3	immune	immune	JJ
cord-307860-iqk1yiw4	441	4	evasion	evasion	NN
cord-307860-iqk1yiw4	441	5	depends	depend	VBZ
cord-307860-iqk1yiw4	441	6	on	on	IN
cord-307860-iqk1yiw4	441	7	more	more	JJR
cord-307860-iqk1yiw4	441	8	than	than	IN
cord-307860-iqk1yiw4	441	9	one	one	CD
cord-307860-iqk1yiw4	441	10	factor	factor	NN
cord-307860-iqk1yiw4	441	11	and	and	CC
cord-307860-iqk1yiw4	441	12	structural	structural	JJ
cord-307860-iqk1yiw4	441	13	work	work	NN
cord-307860-iqk1yiw4	441	14	of	of	IN
cord-307860-iqk1yiw4	441	15	many	many	JJ
cord-307860-iqk1yiw4	441	16	research	research	NN
cord-307860-iqk1yiw4	441	17	teams	team	NNS
cord-307860-iqk1yiw4	441	18	greatly	greatly	RB
cord-307860-iqk1yiw4	441	19	advances	advance	VBZ
cord-307860-iqk1yiw4	441	20	the	the	DT
cord-307860-iqk1yiw4	441	21	understanding	understanding	NN
cord-307860-iqk1yiw4	441	22	of	of	IN
cord-307860-iqk1yiw4	441	23	immune	immune	JJ
cord-307860-iqk1yiw4	441	24	response	response	NN
cord-307860-iqk1yiw4	441	25	.	.	.
cord-307860-iqk1yiw4	442	1	The	the	DT
cord-307860-iqk1yiw4	442	2	SARS	SARS	NNP
cord-307860-iqk1yiw4	442	3	-	-	HYPH
cord-307860-iqk1yiw4	442	4	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	442	5	nsp1	nsp1	NN
cord-307860-iqk1yiw4	442	6	is	be	VBZ
cord-307860-iqk1yiw4	442	7	one	one	CD
cord-307860-iqk1yiw4	442	8	of	of	IN
cord-307860-iqk1yiw4	442	9	the	the	DT
cord-307860-iqk1yiw4	442	10	major	major	JJ
cord-307860-iqk1yiw4	442	11	immune	immune	JJ
cord-307860-iqk1yiw4	442	12	factors	factor	NNS
cord-307860-iqk1yiw4	442	13	that	that	WDT
cord-307860-iqk1yiw4	442	14	impedes	impede	VBZ
cord-307860-iqk1yiw4	442	15	the	the	DT
cord-307860-iqk1yiw4	442	16	host	host	NN
cord-307860-iqk1yiw4	442	17	immune	immune	JJ
cord-307860-iqk1yiw4	442	18	clearance	clearance	NN
cord-307860-iqk1yiw4	442	19	.	.	.
cord-307860-iqk1yiw4	443	1	A	a	DT
cord-307860-iqk1yiw4	443	2	recent	recent	JJ
cord-307860-iqk1yiw4	443	3	structural	structural	JJ
cord-307860-iqk1yiw4	443	4	work	work	NN
cord-307860-iqk1yiw4	443	5	demonstrated	demonstrate	VBD
cord-307860-iqk1yiw4	443	6	that	that	IN
cord-307860-iqk1yiw4	443	7	SARS	SARS	NNP
cord-307860-iqk1yiw4	443	8	-	-	HYPH
cord-307860-iqk1yiw4	443	9	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	443	10	nsp1	nsp1	VBZ
cord-307860-iqk1yiw4	443	11	blocks	block	VBZ
cord-307860-iqk1yiw4	443	12	RIG	rig	NN
cord-307860-iqk1yiw4	443	13	-	-	:
cord-307860-iqk1yiw4	443	14	Idependent	Idependent	NNP
cord-307860-iqk1yiw4	443	15	innate	innate	VBP
cord-307860-iqk1yiw4	443	16	immune	immune	JJ
cord-307860-iqk1yiw4	443	17	response	response	NN
cord-307860-iqk1yiw4	443	18	[	[	-LRB-
cord-307860-iqk1yiw4	443	19	46	46	CD
cord-307860-iqk1yiw4	443	20	]	]	-RRB-
cord-307860-iqk1yiw4	443	21	.	.	.
cord-307860-iqk1yiw4	444	1	The	the	DT
cord-307860-iqk1yiw4	444	2	hypothesis	hypothesis	NN
cord-307860-iqk1yiw4	444	3	of	of	IN
cord-307860-iqk1yiw4	444	4	the	the	DT
cord-307860-iqk1yiw4	444	5	bats	bat	NNS
cord-307860-iqk1yiw4	444	6	being	be	VBG
cord-307860-iqk1yiw4	444	7	at	at	IN
cord-307860-iqk1yiw4	444	8	the	the	DT
cord-307860-iqk1yiw4	444	9	origin	origin	NN
cord-307860-iqk1yiw4	444	10	of	of	IN
cord-307860-iqk1yiw4	444	11	the	the	DT
cord-307860-iqk1yiw4	444	12	SARS	SARS	NNP
cord-307860-iqk1yiw4	444	13	-	-	HYPH
cord-307860-iqk1yiw4	444	14	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	444	15	is	be	VBZ
cord-307860-iqk1yiw4	444	16	,	,	,
cord-307860-iqk1yiw4	444	17	until	until	IN
cord-307860-iqk1yiw4	444	18	now	now	RB
cord-307860-iqk1yiw4	444	19	,	,	,
cord-307860-iqk1yiw4	444	20	not	not	RB
cord-307860-iqk1yiw4	444	21	either	either	CC
cord-307860-iqk1yiw4	444	22	demonstrated	demonstrate	VBN
cord-307860-iqk1yiw4	444	23	or	or	CC
cord-307860-iqk1yiw4	444	24	rejected	reject	VBN
cord-307860-iqk1yiw4	444	25	.	.	.
cord-307860-iqk1yiw4	445	1	However	however	RB
cord-307860-iqk1yiw4	445	2	,	,	,
cord-307860-iqk1yiw4	445	3	it	-PRON-	PRP
cord-307860-iqk1yiw4	445	4	is	be	VBZ
cord-307860-iqk1yiw4	445	5	about	about	RB
cord-307860-iqk1yiw4	445	6	96	96	CD
cord-307860-iqk1yiw4	445	7	%	%	NN
cord-307860-iqk1yiw4	445	8	identity	identity	NN
cord-307860-iqk1yiw4	445	9	between	between	IN
cord-307860-iqk1yiw4	445	10	the	the	DT
cord-307860-iqk1yiw4	445	11	genome	genome	NN
cord-307860-iqk1yiw4	445	12	of	of	IN
cord-307860-iqk1yiw4	445	13	SARS	SARS	NNP
cord-307860-iqk1yiw4	445	14	-	-	HYPH
cord-307860-iqk1yiw4	445	15	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	445	16	and	and	CC
cord-307860-iqk1yiw4	445	17	the	the	DT
cord-307860-iqk1yiw4	445	18	genome	genome	NN
cord-307860-iqk1yiw4	445	19	of	of	IN
cord-307860-iqk1yiw4	445	20	BatCov	BatCov	NNP
cord-307860-iqk1yiw4	445	21	RaTG13	RaTG13	NNP
cord-307860-iqk1yiw4	445	22	[	[	-LRB-
cord-307860-iqk1yiw4	445	23	3	3	CD
cord-307860-iqk1yiw4	445	24	]	]	-RRB-
cord-307860-iqk1yiw4	445	25	.	.	.
cord-307860-iqk1yiw4	446	1	Even	even	RB
cord-307860-iqk1yiw4	446	2	the	the	DT
cord-307860-iqk1yiw4	446	3	genome	genome	NN
cord-307860-iqk1yiw4	446	4	identity	identity	NN
cord-307860-iqk1yiw4	446	5	between	between	IN
cord-307860-iqk1yiw4	446	6	SARS	SARS	NNP
cord-307860-iqk1yiw4	446	7	-	-	HYPH
cord-307860-iqk1yiw4	446	8	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	446	9	and	and	CC
cord-307860-iqk1yiw4	446	10	SARS	SARS	NNP
cord-307860-iqk1yiw4	446	11	-	-	HYPH
cord-307860-iqk1yiw4	446	12	CoV	CoV	NNP
cord-307860-iqk1yiw4	446	13	is	be	VBZ
cord-307860-iqk1yiw4	446	14	about	about	RB
cord-307860-iqk1yiw4	446	15	80%-recent	80%-recent	CD
cord-307860-iqk1yiw4	446	16	studies	study	NNS
cord-307860-iqk1yiw4	446	17	claim	claim	VBP
cord-307860-iqk1yiw4	446	18	Fig	Fig	NNP
cord-307860-iqk1yiw4	446	19	.	.	.
cord-307860-iqk1yiw4	447	1	10	10	CD
cord-307860-iqk1yiw4	448	1	The	the	DT
cord-307860-iqk1yiw4	448	2	multiple	multiple	JJ
cord-307860-iqk1yiw4	448	3	sequence	sequence	NN
cord-307860-iqk1yiw4	448	4	alignment	alignment	NN
cord-307860-iqk1yiw4	448	5	of	of	IN
cord-307860-iqk1yiw4	448	6	nsp9	nsp9	DT
cord-307860-iqk1yiw4	448	7	sequences	sequence	NNS
cord-307860-iqk1yiw4	448	8	using	use	VBG
cord-307860-iqk1yiw4	448	9	the	the	DT
cord-307860-iqk1yiw4	448	10	Clustal	Clustal	NNP
cord-307860-iqk1yiw4	448	11	Omega	Omega	NNP
cord-307860-iqk1yiw4	448	12	program	program	NN
cord-307860-iqk1yiw4	448	13	.	.	.
cord-307860-iqk1yiw4	449	1	The	the	DT
cord-307860-iqk1yiw4	449	2	N	N	NNP
cord-307860-iqk1yiw4	449	3	-	-	HYPH
cord-307860-iqk1yiw4	449	4	finger	finger	NN
cord-307860-iqk1yiw4	449	5	(	(	-LRB-
cord-307860-iqk1yiw4	449	6	in	in	IN
cord-307860-iqk1yiw4	449	7	red	red	JJ
cord-307860-iqk1yiw4	449	8	)	)	-RRB-
cord-307860-iqk1yiw4	449	9	and	and	CC
cord-307860-iqk1yiw4	449	10	GXXXG	GXXXG	NNP
cord-307860-iqk1yiw4	449	11	motif	motif	NN
cord-307860-iqk1yiw4	449	12	(	(	-LRB-
cord-307860-iqk1yiw4	449	13	grey	grey	JJ
cord-307860-iqk1yiw4	449	14	background	background	NN
cord-307860-iqk1yiw4	449	15	)	)	-RRB-
cord-307860-iqk1yiw4	449	16	are	be	VBP
cord-307860-iqk1yiw4	449	17	important	important	JJ
cord-307860-iqk1yiw4	449	18	for	for	IN
cord-307860-iqk1yiw4	449	19	dimerization	dimerization	NN
cord-307860-iqk1yiw4	449	20	.	.	.
cord-307860-iqk1yiw4	450	1	The	the	DT
cord-307860-iqk1yiw4	450	2	conserved	conserved	JJ
cord-307860-iqk1yiw4	450	3	residues	residue	NNS
cord-307860-iqk1yiw4	450	4	of	of	IN
cord-307860-iqk1yiw4	450	5	N	n	NN
cord-307860-iqk1yiw4	450	6	-	-	HYPH
cord-307860-iqk1yiw4	450	7	finger	finger	NN
cord-307860-iqk1yiw4	450	8	are	be	VBP
cord-307860-iqk1yiw4	450	9	underlined	underline	VBN
cord-307860-iqk1yiw4	450	10	a	a	DT
cord-307860-iqk1yiw4	450	11	close	close	JJ
cord-307860-iqk1yiw4	450	12	evolutionary	evolutionary	JJ
cord-307860-iqk1yiw4	450	13	relationship	relationship	NN
cord-307860-iqk1yiw4	450	14	between	between	IN
cord-307860-iqk1yiw4	450	15	the	the	DT
cord-307860-iqk1yiw4	450	16	two	two	CD
cord-307860-iqk1yiw4	450	17	viruses	virus	NNS
cord-307860-iqk1yiw4	450	18	[	[	-LRB-
cord-307860-iqk1yiw4	450	19	3	3	CD
cord-307860-iqk1yiw4	450	20	,	,	,
cord-307860-iqk1yiw4	450	21	101	101	CD
cord-307860-iqk1yiw4	450	22	]	]	-RRB-
cord-307860-iqk1yiw4	450	23	.	.	.
cord-307860-iqk1yiw4	451	1	The	the	DT
cord-307860-iqk1yiw4	451	2	results	result	NNS
cord-307860-iqk1yiw4	451	3	of	of	IN
cord-307860-iqk1yiw4	451	4	the	the	DT
cord-307860-iqk1yiw4	451	5	structural	structural	JJ
cord-307860-iqk1yiw4	451	6	studies	study	NNS
cord-307860-iqk1yiw4	451	7	could	could	MD
cord-307860-iqk1yiw4	451	8	bring	bring	VB
cord-307860-iqk1yiw4	451	9	valuable	valuable	JJ
cord-307860-iqk1yiw4	451	10	perspective	perspective	NN
cord-307860-iqk1yiw4	451	11	of	of	IN
cord-307860-iqk1yiw4	451	12	the	the	DT
cord-307860-iqk1yiw4	451	13	host	host	NN
cord-307860-iqk1yiw4	451	14	specificity	specificity	NN
cord-307860-iqk1yiw4	451	15	.	.	.
cord-307860-iqk1yiw4	452	1	Thus	thus	RB
cord-307860-iqk1yiw4	452	2	,	,	,
cord-307860-iqk1yiw4	452	3	Ziegler	Ziegler	NNP
cord-307860-iqk1yiw4	452	4	et	et	NNP
cord-307860-iqk1yiw4	452	5	al	al	NNP
cord-307860-iqk1yiw4	452	6	.	.	.
cord-307860-iqk1yiw4	453	1	work	work	NN
cord-307860-iqk1yiw4	453	2	about	about	IN
cord-307860-iqk1yiw4	453	3	the	the	DT
cord-307860-iqk1yiw4	453	4	human	human	NN
cord-307860-iqk1yiw4	453	5	and	and	CC
cord-307860-iqk1yiw4	453	6	mouse	mouse	NN
cord-307860-iqk1yiw4	453	7	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	453	8	demonstrated	demonstrate	VBD
cord-307860-iqk1yiw4	453	9	that	that	IN
cord-307860-iqk1yiw4	453	10	different	different	JJ
cord-307860-iqk1yiw4	453	11	to	to	TO
cord-307860-iqk1yiw4	453	12	mouse	mouse	VB
cord-307860-iqk1yiw4	453	13	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	453	14	,	,	,
cord-307860-iqk1yiw4	453	15	the	the	DT
cord-307860-iqk1yiw4	453	16	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	453	17	is	be	VBZ
cord-307860-iqk1yiw4	453	18	an	an	DT
cord-307860-iqk1yiw4	453	19	interferonstimulated	interferonstimulate	VBN
cord-307860-iqk1yiw4	453	20	gene	gene	NN
cord-307860-iqk1yiw4	453	21	(	(	-LRB-
cord-307860-iqk1yiw4	453	22	ISG	ISG	NNP
cord-307860-iqk1yiw4	453	23	)	)	-RRB-
cord-307860-iqk1yiw4	453	24	in	in	IN
cord-307860-iqk1yiw4	453	25	human	human	JJ
cord-307860-iqk1yiw4	453	26	primary	primary	JJ
cord-307860-iqk1yiw4	453	27	upper	upper	JJ
cord-307860-iqk1yiw4	453	28	airway	airway	NN
cord-307860-iqk1yiw4	453	29	epithelial	epithelial	JJ
cord-307860-iqk1yiw4	453	30	basal	basal	NN
cord-307860-iqk1yiw4	453	31	cells	cell	NNS
cord-307860-iqk1yiw4	453	32	[	[	-LRB-
cord-307860-iqk1yiw4	453	33	112	112	CD
cord-307860-iqk1yiw4	453	34	]	]	-RRB-
cord-307860-iqk1yiw4	453	35	.	.	.
cord-307860-iqk1yiw4	454	1	These	these	DT
cord-307860-iqk1yiw4	454	2	results	result	NNS
cord-307860-iqk1yiw4	454	3	are	be	VBP
cord-307860-iqk1yiw4	454	4	useful	useful	JJ
cord-307860-iqk1yiw4	454	5	not	not	RB
cord-307860-iqk1yiw4	454	6	only	only	RB
cord-307860-iqk1yiw4	454	7	for	for	IN
cord-307860-iqk1yiw4	454	8	using	use	VBG
cord-307860-iqk1yiw4	454	9	an	an	DT
cord-307860-iqk1yiw4	454	10	appropriate	appropriate	JJ
cord-307860-iqk1yiw4	454	11	animal	animal	NN
cord-307860-iqk1yiw4	454	12	/	/	SYM
cord-307860-iqk1yiw4	454	13	cellular	cellular	JJ
cord-307860-iqk1yiw4	454	14	model	model	NN
cord-307860-iqk1yiw4	454	15	in	in	IN
cord-307860-iqk1yiw4	454	16	experimental	experimental	JJ
cord-307860-iqk1yiw4	454	17	research	research	NN
cord-307860-iqk1yiw4	454	18	but	but	CC
cord-307860-iqk1yiw4	454	19	for	for	IN
cord-307860-iqk1yiw4	454	20	screening	screening	NN
cord-307860-iqk1yiw4	454	21	for	for	IN
cord-307860-iqk1yiw4	454	22	the	the	DT
cord-307860-iqk1yiw4	454	23	potential	potential	JJ
cord-307860-iqk1yiw4	454	24	animal	animal	NN
cord-307860-iqk1yiw4	454	25	host	host	NN
cord-307860-iqk1yiw4	454	26	of	of	IN
cord-307860-iqk1yiw4	454	27	the	the	DT
cord-307860-iqk1yiw4	454	28	SARS	SARS	NNP
cord-307860-iqk1yiw4	454	29	-	-	HYPH
cord-307860-iqk1yiw4	454	30	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	454	31	,	,	,
cord-307860-iqk1yiw4	454	32	which	which	WDT
cord-307860-iqk1yiw4	454	33	could	could	MD
cord-307860-iqk1yiw4	454	34	elucidate	elucidate	VB
cord-307860-iqk1yiw4	454	35	the	the	DT
cord-307860-iqk1yiw4	454	36	chain	chain	NN
cord-307860-iqk1yiw4	454	37	of	of	IN
cord-307860-iqk1yiw4	454	38	the	the	DT
cord-307860-iqk1yiw4	454	39	virus	virus	NN
cord-307860-iqk1yiw4	454	40	passing	pass	VBG
cord-307860-iqk1yiw4	454	41	from	from	IN
cord-307860-iqk1yiw4	454	42	the	the	DT
cord-307860-iqk1yiw4	454	43	animal	animal	NN
cord-307860-iqk1yiw4	454	44	host	host	NN
cord-307860-iqk1yiw4	454	45	to	to	IN
cord-307860-iqk1yiw4	454	46	human	human	NN
cord-307860-iqk1yiw4	454	47	.	.	.
cord-307860-iqk1yiw4	455	1	Also	also	RB
cord-307860-iqk1yiw4	455	2	,	,	,
cord-307860-iqk1yiw4	455	3	the	the	DT
cord-307860-iqk1yiw4	455	4	differences	difference	NNS
cord-307860-iqk1yiw4	455	5	of	of	IN
cord-307860-iqk1yiw4	455	6	an	an	DT
cord-307860-iqk1yiw4	455	7	essential	essential	JJ
cord-307860-iqk1yiw4	455	8	step	step	NN
cord-307860-iqk1yiw4	455	9	in	in	IN
cord-307860-iqk1yiw4	455	10	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	455	11	replication	replication	NN
cord-307860-iqk1yiw4	455	12	,	,	,
cord-307860-iqk1yiw4	455	13	the	the	DT
cord-307860-iqk1yiw4	455	14	priming	priming	NN
cord-307860-iqk1yiw4	455	15	of	of	IN
cord-307860-iqk1yiw4	455	16	S	S	NNP
cord-307860-iqk1yiw4	455	17	glycoprotein	glycoprotein	NN
cord-307860-iqk1yiw4	455	18	by	by	IN
cord-307860-iqk1yiw4	455	19	host	host	NN
cord-307860-iqk1yiw4	455	20	cell	cell	NN
cord-307860-iqk1yiw4	455	21	proteases	protease	NNS
cord-307860-iqk1yiw4	455	22	,	,	,
cord-307860-iqk1yiw4	455	23	could	could	MD
cord-307860-iqk1yiw4	455	24	be	be	VB
cord-307860-iqk1yiw4	455	25	exploited	exploit	VBN
cord-307860-iqk1yiw4	455	26	to	to	TO
cord-307860-iqk1yiw4	455	27	elucidate	elucidate	VB
cord-307860-iqk1yiw4	455	28	the	the	DT
cord-307860-iqk1yiw4	455	29	zoonotic	zoonotic	JJ
cord-307860-iqk1yiw4	455	30	potential	potential	NN
cord-307860-iqk1yiw4	455	31	of	of	IN
cord-307860-iqk1yiw4	455	32	the	the	DT
cord-307860-iqk1yiw4	455	33	SARS	SARS	NNP
cord-307860-iqk1yiw4	455	34	-	-	HYPH
cord-307860-iqk1yiw4	455	35	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	455	36	.	.	.
cord-307860-iqk1yiw4	456	1	The	the	DT
cord-307860-iqk1yiw4	456	2	findings	finding	NNS
cord-307860-iqk1yiw4	456	3	of	of	IN
cord-307860-iqk1yiw4	456	4	Hoffmann	Hoffmann	NNP
cord-307860-iqk1yiw4	456	5	et	et	NNP
cord-307860-iqk1yiw4	456	6	al	al	NNP
cord-307860-iqk1yiw4	456	7	.	.	NNP
cord-307860-iqk1yiw4	456	8	highlighted	highlight	VBD
cord-307860-iqk1yiw4	456	9	that	that	IN
cord-307860-iqk1yiw4	456	10	the	the	DT
cord-307860-iqk1yiw4	456	11	S1	S1	NNP
cord-307860-iqk1yiw4	456	12	/	/	SYM
cord-307860-iqk1yiw4	456	13	S2	S2	NNP
cord-307860-iqk1yiw4	456	14	cleavage	cleavage	NN
cord-307860-iqk1yiw4	456	15	site	site	NN
cord-307860-iqk1yiw4	456	16	sequence	sequence	NN
cord-307860-iqk1yiw4	456	17	of	of	IN
cord-307860-iqk1yiw4	456	18	SARS	SARS	NNP
cord-307860-iqk1yiw4	456	19	-	-	HYPH
cord-307860-iqk1yiw4	456	20	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	456	21	S	S	NNP
cord-307860-iqk1yiw4	456	22	glycoprotein	glycoprotein	NN
cord-307860-iqk1yiw4	456	23	harbors	harbor	VBZ
cord-307860-iqk1yiw4	456	24	several	several	JJ
cord-307860-iqk1yiw4	456	25	arginine	arginine	NN
cord-307860-iqk1yiw4	456	26	residues	residue	NNS
cord-307860-iqk1yiw4	456	27	(	(	-LRB-
cord-307860-iqk1yiw4	456	28	multibasic	multibasic	NNP
cord-307860-iqk1yiw4	456	29	)	)	-RRB-
cord-307860-iqk1yiw4	456	30	on	on	IN
cord-307860-iqk1yiw4	456	31	the	the	DT
cord-307860-iqk1yiw4	456	32	contrary	contrary	NN
cord-307860-iqk1yiw4	456	33	to	to	IN
cord-307860-iqk1yiw4	456	34	its	-PRON-	PRP$
cord-307860-iqk1yiw4	456	35	closely	closely	RB
cord-307860-iqk1yiw4	456	36	related	relate	VBN
cord-307860-iqk1yiw4	456	37	the	the	DT
cord-307860-iqk1yiw4	456	38	bat	bat	NN
cord-307860-iqk1yiw4	457	1	CoV	CoV	NNP
cord-307860-iqk1yiw4	457	2	RaTG13	RaTG13	NNP
cord-307860-iqk1yiw4	457	3	[	[	-LRB-
cord-307860-iqk1yiw4	457	4	94	94	CD
cord-307860-iqk1yiw4	457	5	]	]	-RRB-
cord-307860-iqk1yiw4	457	6	.	.	.
cord-307860-iqk1yiw4	458	1	Current	current	JJ
cord-307860-iqk1yiw4	458	2	theory	theory	NN
cord-307860-iqk1yiw4	458	3	holds	hold	VBZ
cord-307860-iqk1yiw4	458	4	that	that	IN
cord-307860-iqk1yiw4	458	5	most	most	JJS
cord-307860-iqk1yiw4	458	6	of	of	IN
cord-307860-iqk1yiw4	458	7	the	the	DT
cord-307860-iqk1yiw4	458	8	deaths	death	NNS
cord-307860-iqk1yiw4	458	9	are	be	VBP
cord-307860-iqk1yiw4	458	10	due	due	JJ
cord-307860-iqk1yiw4	458	11	to	to	IN
cord-307860-iqk1yiw4	458	12	an	an	DT
cord-307860-iqk1yiw4	458	13	excessive	excessive	JJ
cord-307860-iqk1yiw4	458	14	level	level	NN
cord-307860-iqk1yiw4	458	15	of	of	IN
cord-307860-iqk1yiw4	458	16	pro	pro	JJ
cord-307860-iqk1yiw4	458	17	-	-	JJ
cord-307860-iqk1yiw4	458	18	inflammatory	inflammatory	JJ
cord-307860-iqk1yiw4	458	19	cytokines	cytokine	NNS
cord-307860-iqk1yiw4	458	20	in	in	IN
cord-307860-iqk1yiw4	458	21	circulation	circulation	NN
cord-307860-iqk1yiw4	458	22	.	.	.
cord-307860-iqk1yiw4	459	1	The	the	DT
cord-307860-iqk1yiw4	459	2	humoral	humoral	JJ
cord-307860-iqk1yiw4	459	3	immune	immune	JJ
cord-307860-iqk1yiw4	459	4	response	response	NN
cord-307860-iqk1yiw4	459	5	is	be	VBZ
cord-307860-iqk1yiw4	459	6	most	most	RBS
cord-307860-iqk1yiw4	459	7	studied	study	VBN
cord-307860-iqk1yiw4	459	8	and	and	CC
cord-307860-iqk1yiw4	459	9	structural	structural	JJ
cord-307860-iqk1yiw4	459	10	studies	study	NNS
cord-307860-iqk1yiw4	459	11	add	add	VBP
cord-307860-iqk1yiw4	459	12	important	important	JJ
cord-307860-iqk1yiw4	459	13	results	result	NNS
cord-307860-iqk1yiw4	459	14	that	that	WDT
cord-307860-iqk1yiw4	459	15	further	further	RB
cord-307860-iqk1yiw4	459	16	explain	explain	VBP
cord-307860-iqk1yiw4	459	17	biochemical	biochemical	JJ
cord-307860-iqk1yiw4	459	18	findings	finding	NNS
cord-307860-iqk1yiw4	459	19	[	[	-LRB-
cord-307860-iqk1yiw4	459	20	121	121	CD
cord-307860-iqk1yiw4	459	21	]	]	-RRB-
cord-307860-iqk1yiw4	459	22	.	.	.
cord-307860-iqk1yiw4	460	1	The	the	DT
cord-307860-iqk1yiw4	460	2	most	most	RBS
cord-307860-iqk1yiw4	460	3	optimistic	optimistic	JJ
cord-307860-iqk1yiw4	460	4	outcome	outcome	NN
cord-307860-iqk1yiw4	460	5	is	be	VBZ
cord-307860-iqk1yiw4	460	6	to	to	TO
cord-307860-iqk1yiw4	460	7	obtain	obtain	VB
cord-307860-iqk1yiw4	460	8	a	a	DT
cord-307860-iqk1yiw4	460	9	vaccine	vaccine	NN
cord-307860-iqk1yiw4	460	10	that	that	WDT
cord-307860-iqk1yiw4	460	11	elicits	elicit	VBZ
cord-307860-iqk1yiw4	460	12	strong	strong	JJ
cord-307860-iqk1yiw4	460	13	and	and	CC
cord-307860-iqk1yiw4	460	14	long	long	JJ
cord-307860-iqk1yiw4	460	15	-	-	HYPH
cord-307860-iqk1yiw4	460	16	term	term	NN
cord-307860-iqk1yiw4	460	17	immunity	immunity	NN
cord-307860-iqk1yiw4	460	18	.	.	.
cord-307860-iqk1yiw4	461	1	Until	until	IN
cord-307860-iqk1yiw4	461	2	then	then	RB
cord-307860-iqk1yiw4	461	3	,	,	,
cord-307860-iqk1yiw4	461	4	understanding	understand	VBG
cord-307860-iqk1yiw4	461	5	the	the	DT
cord-307860-iqk1yiw4	461	6	evolutions	evolution	NNS
cord-307860-iqk1yiw4	461	7	of	of	IN
cord-307860-iqk1yiw4	461	8	phenotypic	phenotypic	JJ
cord-307860-iqk1yiw4	461	9	changes	change	NNS
cord-307860-iqk1yiw4	461	10	of	of	IN
cord-307860-iqk1yiw4	461	11	the	the	DT
cord-307860-iqk1yiw4	461	12	SARS	SARS	NNP
cord-307860-iqk1yiw4	461	13	-	-	HYPH
cord-307860-iqk1yiw4	461	14	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	461	15	and	and	CC
cord-307860-iqk1yiw4	461	16	elucidation	elucidation	NN
cord-307860-iqk1yiw4	461	17	of	of	IN
cord-307860-iqk1yiw4	461	18	epidemiological	epidemiological	JJ
cord-307860-iqk1yiw4	461	19	aspects	aspect	NNS
cord-307860-iqk1yiw4	461	20	of	of	IN
cord-307860-iqk1yiw4	461	21	the	the	DT
cord-307860-iqk1yiw4	461	22	COVID-19	covid-19	JJ
cord-307860-iqk1yiw4	461	23	pandemic	pandemic	NN
cord-307860-iqk1yiw4	461	24	greatly	greatly	RB
cord-307860-iqk1yiw4	461	25	depends	depend	VBZ
cord-307860-iqk1yiw4	461	26	on	on	IN
cord-307860-iqk1yiw4	461	27	the	the	DT
cord-307860-iqk1yiw4	461	28	analysis	analysis	NN
cord-307860-iqk1yiw4	461	29	of	of	IN
cord-307860-iqk1yiw4	461	30	all	all	DT
cord-307860-iqk1yiw4	461	31	available	available	JJ
cord-307860-iqk1yiw4	461	32	research	research	NN
cord-307860-iqk1yiw4	461	33	results	result	NNS
cord-307860-iqk1yiw4	461	34	.	.	.
cord-307860-iqk1yiw4	462	1	There	there	EX
cord-307860-iqk1yiw4	462	2	is	be	VBZ
cord-307860-iqk1yiw4	462	3	a	a	DT
cord-307860-iqk1yiw4	462	4	huge	huge	JJ
cord-307860-iqk1yiw4	462	5	effort	effort	NN
cord-307860-iqk1yiw4	462	6	in	in	IN
cord-307860-iqk1yiw4	462	7	deciphering	decipher	VBG
cord-307860-iqk1yiw4	462	8	the	the	DT
cord-307860-iqk1yiw4	462	9	SARS	SARS	NNP
cord-307860-iqk1yiw4	462	10	-	-	HYPH
cord-307860-iqk1yiw4	462	11	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	462	12	pandemic	pandemic	NN
cord-307860-iqk1yiw4	462	13	,	,	,
cord-307860-iqk1yiw4	462	14	leading	lead	VBG
cord-307860-iqk1yiw4	462	15	to	to	IN
cord-307860-iqk1yiw4	462	16	many	many	JJ
cord-307860-iqk1yiw4	462	17	studies	study	NNS
cord-307860-iqk1yiw4	462	18	conducted	conduct	VBN
cord-307860-iqk1yiw4	462	19	around	around	IN
cord-307860-iqk1yiw4	462	20	the	the	DT
cord-307860-iqk1yiw4	462	21	world	world	NN
cord-307860-iqk1yiw4	462	22	.	.	.
cord-307860-iqk1yiw4	463	1	The	the	DT
cord-307860-iqk1yiw4	463	2	scientific	scientific	JJ
cord-307860-iqk1yiw4	463	3	work	work	NN
cord-307860-iqk1yiw4	463	4	relies	rely	VBZ
cord-307860-iqk1yiw4	463	5	on	on	IN
cord-307860-iqk1yiw4	463	6	observation	observation	NN
cord-307860-iqk1yiw4	463	7	,	,	,
cord-307860-iqk1yiw4	463	8	experiments	experiment	NNS
cord-307860-iqk1yiw4	463	9	,	,	,
cord-307860-iqk1yiw4	463	10	and	and	CC
cord-307860-iqk1yiw4	463	11	structural	structural	JJ
cord-307860-iqk1yiw4	463	12	studies	study	NNS
cord-307860-iqk1yiw4	463	13	to	to	TO
cord-307860-iqk1yiw4	463	14	provide	provide	VB
cord-307860-iqk1yiw4	463	15	a	a	DT
cord-307860-iqk1yiw4	463	16	deep	deep	JJ
cord-307860-iqk1yiw4	463	17	view	view	NN
cord-307860-iqk1yiw4	463	18	of	of	IN
cord-307860-iqk1yiw4	463	19	SARS	SARS	NNP
cord-307860-iqk1yiw4	463	20	-	-	HYPH
cord-307860-iqk1yiw4	463	21	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	463	22	.	.	.
cord-307860-iqk1yiw4	464	1	The	the	DT
cord-307860-iqk1yiw4	464	2	current	current	JJ
cord-307860-iqk1yiw4	464	3	structural	structural	JJ
cord-307860-iqk1yiw4	464	4	analysis	analysis	NN
cord-307860-iqk1yiw4	464	5	of	of	IN
cord-307860-iqk1yiw4	464	6	the	the	DT
cord-307860-iqk1yiw4	464	7	SARS	SARS	NNP
cord-307860-iqk1yiw4	464	8	-	-	HYPH
cord-307860-iqk1yiw4	464	9	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	464	10	is	be	VBZ
cord-307860-iqk1yiw4	464	11	mainly	mainly	RB
cord-307860-iqk1yiw4	464	12	focused	focus	VBN
cord-307860-iqk1yiw4	464	13	on	on	IN
cord-307860-iqk1yiw4	464	14	three	three	CD
cord-307860-iqk1yiw4	464	15	major	major	JJ
cord-307860-iqk1yiw4	464	16	lines	line	NNS
cord-307860-iqk1yiw4	464	17	-	-	:
cord-307860-iqk1yiw4	464	18	finding	find	VBG
cord-307860-iqk1yiw4	464	19	new	new	JJ
cord-307860-iqk1yiw4	464	20	hydrolase	hydrolase	NN
cord-307860-iqk1yiw4	464	21	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	464	22	,	,	,
cord-307860-iqk1yiw4	464	23	the	the	DT
cord-307860-iqk1yiw4	464	24	virus	virus	NN
cord-307860-iqk1yiw4	464	25	-	-	HYPH
cord-307860-iqk1yiw4	464	26	host	host	NN
cord-307860-iqk1yiw4	464	27	cell	cell	NN
cord-307860-iqk1yiw4	464	28	invasion	invasion	NN
cord-307860-iqk1yiw4	464	29	,	,	,
cord-307860-iqk1yiw4	464	30	and	and	CC
cord-307860-iqk1yiw4	464	31	the	the	DT
cord-307860-iqk1yiw4	464	32	virus	virus	NN
cord-307860-iqk1yiw4	464	33	-	-	HYPH
cord-307860-iqk1yiw4	464	34	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	464	35	antibody	antibody	NN
cord-307860-iqk1yiw4	464	36	interaction	interaction	NN
cord-307860-iqk1yiw4	464	37	.	.	.
cord-307860-iqk1yiw4	465	1	There	there	EX
cord-307860-iqk1yiw4	465	2	is	be	VBZ
cord-307860-iqk1yiw4	465	3	an	an	DT
cord-307860-iqk1yiw4	465	4	intense	intense	JJ
cord-307860-iqk1yiw4	465	5	work	work	NN
cord-307860-iqk1yiw4	465	6	on	on	IN
cord-307860-iqk1yiw4	465	7	structural	structural	JJ
cord-307860-iqk1yiw4	465	8	studies	study	NNS
cord-307860-iqk1yiw4	465	9	of	of	IN
cord-307860-iqk1yiw4	465	10	SARS	SARS	NNP
cord-307860-iqk1yiw4	465	11	-	-	HYPH
cord-307860-iqk1yiw4	465	12	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	465	13	proteins	protein	NNS
cord-307860-iqk1yiw4	465	14	,	,	,
cord-307860-iqk1yiw4	465	15	mainly	mainly	RB
cord-307860-iqk1yiw4	465	16	for	for	IN
cord-307860-iqk1yiw4	465	17	S	s	NN
cord-307860-iqk1yiw4	465	18	glycoprotein	glycoprotein	NN
cord-307860-iqk1yiw4	465	19	that	that	WDT
cord-307860-iqk1yiw4	465	20	is	be	VBZ
cord-307860-iqk1yiw4	465	21	crucial	crucial	JJ
cord-307860-iqk1yiw4	465	22	for	for	IN
cord-307860-iqk1yiw4	465	23	the	the	DT
cord-307860-iqk1yiw4	465	24	pathogenesis	pathogenesis	NN
cord-307860-iqk1yiw4	465	25	of	of	IN
cord-307860-iqk1yiw4	465	26	all	all	DT
cord-307860-iqk1yiw4	465	27	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	465	28	,	,	,
cord-307860-iqk1yiw4	465	29	but	but	CC
cord-307860-iqk1yiw4	465	30	Totum	totum	FW
cord-307860-iqk1yiw4	465	31	est	est	FW
cord-307860-iqk1yiw4	465	32	majus	majus	FW
cord-307860-iqk1yiw4	465	33	sua	sua	FW
cord-307860-iqk1yiw4	465	34	parte	parte	NNP
cord-307860-iqk1yiw4	465	35	(	(	-LRB-
cord-307860-iqk1yiw4	465	36	The	the	DT
cord-307860-iqk1yiw4	465	37	whole	whole	NN
cord-307860-iqk1yiw4	465	38	is	be	VBZ
cord-307860-iqk1yiw4	465	39	bigger	big	JJR
cord-307860-iqk1yiw4	465	40	than	than	IN
cord-307860-iqk1yiw4	465	41	the	the	DT
cord-307860-iqk1yiw4	465	42	part	part	NN
cord-307860-iqk1yiw4	465	43	)	)	-RRB-
cord-307860-iqk1yiw4	465	44	.	.	.
cord-307860-iqk1yiw4	466	1	The	the	DT
cord-307860-iqk1yiw4	466	2	convalescent	convalescent	JJ
cord-307860-iqk1yiw4	466	3	patients	patient	NNS
cord-307860-iqk1yiw4	466	4	'	'	POS
cord-307860-iqk1yiw4	466	5	B	b	NN
cord-307860-iqk1yiw4	466	6	cells	cell	NNS
cord-307860-iqk1yiw4	466	7	demonstrated	demonstrate	VBD
cord-307860-iqk1yiw4	466	8	that	that	IN
cord-307860-iqk1yiw4	466	9	not	not	RB
cord-307860-iqk1yiw4	466	10	a	a	DT
cord-307860-iqk1yiw4	466	11	single	single	JJ
cord-307860-iqk1yiw4	466	12	spike	spike	NN
cord-307860-iqk1yiw4	466	13	epitope	epitope	NN
cord-307860-iqk1yiw4	466	14	elicits	elicit	VBZ
cord-307860-iqk1yiw4	466	15	the	the	DT
cord-307860-iqk1yiw4	466	16	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	466	17	antibodies	antibody	NNS
cord-307860-iqk1yiw4	466	18	.	.	.
cord-307860-iqk1yiw4	467	1	The	the	DT
cord-307860-iqk1yiw4	467	2	host	host	NN
cord-307860-iqk1yiw4	467	3	-	-	HYPH
cord-307860-iqk1yiw4	467	4	virus	virus	NN
cord-307860-iqk1yiw4	467	5	interaction	interaction	NN
cord-307860-iqk1yiw4	467	6	is	be	VBZ
cord-307860-iqk1yiw4	467	7	a	a	DT
cord-307860-iqk1yiw4	467	8	dynamic	dynamic	JJ
cord-307860-iqk1yiw4	467	9	process	process	NN
cord-307860-iqk1yiw4	467	10	,	,	,
cord-307860-iqk1yiw4	467	11	and	and	CC
cord-307860-iqk1yiw4	467	12	the	the	DT
cord-307860-iqk1yiw4	467	13	host	host	NN
cord-307860-iqk1yiw4	467	14	's	's	POS
cord-307860-iqk1yiw4	467	15	defense	defense	NN
cord-307860-iqk1yiw4	467	16	mechanisms	mechanism	NNS
cord-307860-iqk1yiw4	467	17	are	be	VBP
cord-307860-iqk1yiw4	467	18	crucial	crucial	JJ
cord-307860-iqk1yiw4	467	19	not	not	RB
cord-307860-iqk1yiw4	467	20	only	only	RB
cord-307860-iqk1yiw4	467	21	to	to	TO
cord-307860-iqk1yiw4	467	22	cure	cure	VB
cord-307860-iqk1yiw4	467	23	the	the	DT
cord-307860-iqk1yiw4	467	24	COVID-19	covid-19	JJ
cord-307860-iqk1yiw4	467	25	infection	infection	NN
cord-307860-iqk1yiw4	467	26	but	but	CC
cord-307860-iqk1yiw4	467	27	to	to	TO
cord-307860-iqk1yiw4	467	28	prevent	prevent	VB
cord-307860-iqk1yiw4	467	29	further	further	JJ
cord-307860-iqk1yiw4	467	30	re	re	NN
cord-307860-iqk1yiw4	467	31	-	-	NN
cord-307860-iqk1yiw4	467	32	infection	infection	NN
cord-307860-iqk1yiw4	467	33	.	.	.
cord-307860-iqk1yiw4	468	1	In	in	IN
cord-307860-iqk1yiw4	468	2	this	this	DT
cord-307860-iqk1yiw4	468	3	sense	sense	NN
cord-307860-iqk1yiw4	468	4	,	,	,
cord-307860-iqk1yiw4	468	5	structural	structural	JJ
cord-307860-iqk1yiw4	468	6	studies	study	NNS
cord-307860-iqk1yiw4	468	7	involving	involve	VBG
cord-307860-iqk1yiw4	468	8	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	468	9	antibodies	antibody	NNS
cord-307860-iqk1yiw4	468	10	gain	gain	VBP
cord-307860-iqk1yiw4	468	11	a	a	DT
cord-307860-iqk1yiw4	468	12	perspective	perspective	NN
cord-307860-iqk1yiw4	468	13	in	in	IN
cord-307860-iqk1yiw4	468	14	deciphering	decipher	VBG
cord-307860-iqk1yiw4	468	15	the	the	DT
cord-307860-iqk1yiw4	468	16	immunity	immunity	NN
cord-307860-iqk1yiw4	468	17	of	of	IN
cord-307860-iqk1yiw4	468	18	cured	cure	VBN
cord-307860-iqk1yiw4	468	19	persons	person	NNS
cord-307860-iqk1yiw4	468	20	.	.	.
cord-307860-iqk1yiw4	469	1	Also	also	RB
cord-307860-iqk1yiw4	469	2	,	,	,
cord-307860-iqk1yiw4	469	3	the	the	DT
cord-307860-iqk1yiw4	469	4	works	work	NNS
cord-307860-iqk1yiw4	469	5	about	about	IN
cord-307860-iqk1yiw4	469	6	the	the	DT
cord-307860-iqk1yiw4	469	7	viral	viral	JJ
cord-307860-iqk1yiw4	469	8	nsp(s	nsp(s	NN
cord-307860-iqk1yiw4	469	9	)	)	-RRB-
cord-307860-iqk1yiw4	469	10	aid	aid	VB
cord-307860-iqk1yiw4	469	11	the	the	DT
cord-307860-iqk1yiw4	469	12	understanding	understanding	NN
cord-307860-iqk1yiw4	469	13	of	of	IN
cord-307860-iqk1yiw4	469	14	the	the	DT
cord-307860-iqk1yiw4	469	15	viral	viral	JJ
cord-307860-iqk1yiw4	469	16	immune	immune	JJ
cord-307860-iqk1yiw4	469	17	evasion	evasion	NN
cord-307860-iqk1yiw4	469	18	.	.	.
cord-307860-iqk1yiw4	470	1	Despite	despite	IN
cord-307860-iqk1yiw4	470	2	the	the	DT
cord-307860-iqk1yiw4	470	3	limits	limit	NNS
cord-307860-iqk1yiw4	470	4	of	of	IN
cord-307860-iqk1yiw4	470	5	X	x	NN
cord-307860-iqk1yiw4	470	6	-	-	NN
cord-307860-iqk1yiw4	470	7	ray	ray	NN
cord-307860-iqk1yiw4	470	8	/	/	SYM
cord-307860-iqk1yiw4	470	9	cryo	cryo	NN
cord-307860-iqk1yiw4	470	10	-	-	HYPH
cord-307860-iqk1yiw4	470	11	EM	EM	NNP
cord-307860-iqk1yiw4	470	12	crystal	crystal	NN
cord-307860-iqk1yiw4	470	13	structure	structure	NN
cord-307860-iqk1yiw4	470	14	studies	study	NNS
cord-307860-iqk1yiw4	470	15	-mainly	-mainly	RB
cord-307860-iqk1yiw4	470	16	the	the	DT
cord-307860-iqk1yiw4	470	17	lack	lack	NN
cord-307860-iqk1yiw4	470	18	of	of	IN
cord-307860-iqk1yiw4	470	19	information	information	NN
cord-307860-iqk1yiw4	470	20	about	about	IN
cord-307860-iqk1yiw4	470	21	the	the	DT
cord-307860-iqk1yiw4	470	22	cell	cell	NN
cord-307860-iqk1yiw4	470	23	-	-	HYPH
cord-307860-iqk1yiw4	470	24	mediated	mediate	VBN
cord-307860-iqk1yiw4	470	25	immunity	immunity	NN
cord-307860-iqk1yiw4	470	26	and	and	CC
cord-307860-iqk1yiw4	470	27	time	time	NN
cord-307860-iqk1yiw4	470	28	-	-	HYPH
cord-307860-iqk1yiw4	470	29	consuming	consume	VBG
cord-307860-iqk1yiw4	470	30	experiments	experiment	NNS
cord-307860-iqk1yiw4	470	31	for	for	IN
cord-307860-iqk1yiw4	470	32	clinical	clinical	JJ
cord-307860-iqk1yiw4	470	33	validation	validation	NN
cord-307860-iqk1yiw4	470	34	of	of	IN
cord-307860-iqk1yiw4	470	35	the	the	DT
cord-307860-iqk1yiw4	470	36	new	new	JJ
cord-307860-iqk1yiw4	470	37	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	470	38	-the	-the	DT
cord-307860-iqk1yiw4	470	39	thorough	thorough	JJ
cord-307860-iqk1yiw4	470	40	analysis	analysis	NN
cord-307860-iqk1yiw4	470	41	of	of	IN
cord-307860-iqk1yiw4	470	42	the	the	DT
cord-307860-iqk1yiw4	470	43	PDB	PDB	NNP
cord-307860-iqk1yiw4	470	44	entries	entry	NNS
cord-307860-iqk1yiw4	470	45	is	be	VBZ
cord-307860-iqk1yiw4	470	46	a	a	DT
cord-307860-iqk1yiw4	470	47	powerful	powerful	JJ
cord-307860-iqk1yiw4	470	48	tool	tool	NN
cord-307860-iqk1yiw4	470	49	for	for	IN
cord-307860-iqk1yiw4	470	50	further	further	JJ
cord-307860-iqk1yiw4	470	51	understanding	understanding	NN
cord-307860-iqk1yiw4	470	52	of	of	IN
cord-307860-iqk1yiw4	470	53	the	the	DT
cord-307860-iqk1yiw4	470	54	human	human	JJ
cord-307860-iqk1yiw4	470	55	CoVs	CoVs	NNP
cord-307860-iqk1yiw4	470	56	infections	infection	NNS
cord-307860-iqk1yiw4	470	57	.	.	.
cord-307860-iqk1yiw4	471	1	Emergence	emergence	NN
cord-307860-iqk1yiw4	471	2	of	of	IN
cord-307860-iqk1yiw4	471	3	novel	novel	JJ
cord-307860-iqk1yiw4	471	4	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	471	5	and	and	CC
cord-307860-iqk1yiw4	471	6	COVID-19	covid-19	NN
cord-307860-iqk1yiw4	471	7	:	:	:
cord-307860-iqk1yiw4	471	8	whether	whether	IN
cord-307860-iqk1yiw4	471	9	to	to	TO
cord-307860-iqk1yiw4	471	10	stay	stay	VB
cord-307860-iqk1yiw4	471	11	or	or	CC
cord-307860-iqk1yiw4	471	12	die	die	VB
cord-307860-iqk1yiw4	471	13	out	out	RP
cord-307860-iqk1yiw4	471	14	?	?	.
cord-307860-iqk1yiw4	472	1	The	the	DT
cord-307860-iqk1yiw4	472	2	origin	origin	NN
cord-307860-iqk1yiw4	472	3	,	,	,
cord-307860-iqk1yiw4	472	4	transmission	transmission	NN
cord-307860-iqk1yiw4	472	5	and	and	CC
cord-307860-iqk1yiw4	472	6	clinical	clinical	JJ
cord-307860-iqk1yiw4	472	7	therapies	therapy	NNS
cord-307860-iqk1yiw4	472	8	on	on	IN
cord-307860-iqk1yiw4	472	9	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	472	10	disease	disease	NN
cord-307860-iqk1yiw4	472	11	2019	2019	CD
cord-307860-iqk1yiw4	473	1	(	(	-LRB-
cord-307860-iqk1yiw4	473	2	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	473	3	)	)	-RRB-
cord-307860-iqk1yiw4	473	4	outbreak	outbreak	NN
cord-307860-iqk1yiw4	473	5	:	:	:
cord-307860-iqk1yiw4	473	6	an	an	DT
cord-307860-iqk1yiw4	473	7	update	update	NN
cord-307860-iqk1yiw4	473	8	on	on	IN
cord-307860-iqk1yiw4	473	9	the	the	DT
cord-307860-iqk1yiw4	473	10	status	status	NN
cord-307860-iqk1yiw4	474	1	A	a	DT
cord-307860-iqk1yiw4	474	2	pneumonia	pneumonia	NN
cord-307860-iqk1yiw4	474	3	outbreak	outbreak	NN
cord-307860-iqk1yiw4	474	4	associated	associate	VBN
cord-307860-iqk1yiw4	474	5	with	with	IN
cord-307860-iqk1yiw4	474	6	a	a	DT
cord-307860-iqk1yiw4	474	7	new	new	JJ
cord-307860-iqk1yiw4	474	8	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	474	9	of	of	IN
cord-307860-iqk1yiw4	474	10	probable	probable	JJ
cord-307860-iqk1yiw4	474	11	bat	bat	NN
cord-307860-iqk1yiw4	474	12	origin	origin	NN
cord-307860-iqk1yiw4	474	13	Keep	keep	VB
cord-307860-iqk1yiw4	474	14	up	up	RP
cord-307860-iqk1yiw4	474	15	with	with	IN
cord-307860-iqk1yiw4	474	16	the	the	DT
cord-307860-iqk1yiw4	474	17	latest	late	JJS
cord-307860-iqk1yiw4	474	18	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	474	19	research	research	NN
cord-307860-iqk1yiw4	474	20	Origin	origin	NN
cord-307860-iqk1yiw4	474	21	and	and	CC
cord-307860-iqk1yiw4	474	22	evolution	evolution	NN
cord-307860-iqk1yiw4	474	23	of	of	IN
cord-307860-iqk1yiw4	474	24	pathogenic	pathogenic	JJ
cord-307860-iqk1yiw4	474	25	coronaviruses	coronaviruse	NNS
cord-307860-iqk1yiw4	474	26	Composition	composition	NN
cord-307860-iqk1yiw4	474	27	and	and	CC
cord-307860-iqk1yiw4	474	28	divergence	divergence	NN
cord-307860-iqk1yiw4	474	29	of	of	IN
cord-307860-iqk1yiw4	474	30	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	474	31	spike	spike	NN
cord-307860-iqk1yiw4	474	32	proteins	protein	NNS
cord-307860-iqk1yiw4	474	33	and	and	CC
cord-307860-iqk1yiw4	474	34	host	host	NN
cord-307860-iqk1yiw4	474	35	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	474	36	receptors	receptor	NNS
cord-307860-iqk1yiw4	474	37	predict	predict	VBP
cord-307860-iqk1yiw4	474	38	potential	potential	JJ
cord-307860-iqk1yiw4	474	39	intermediate	intermediate	JJ
cord-307860-iqk1yiw4	474	40	hosts	host	NNS
cord-307860-iqk1yiw4	474	41	of	of	IN
cord-307860-iqk1yiw4	474	42	SARS	SARS	NNP
cord-307860-iqk1yiw4	474	43	-	-	HYPH
cord-307860-iqk1yiw4	474	44	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	474	45	Evolutionary	evolutionary	JJ
cord-307860-iqk1yiw4	474	46	history	history	NN
cord-307860-iqk1yiw4	474	47	,	,	,
cord-307860-iqk1yiw4	474	48	potential	potential	JJ
cord-307860-iqk1yiw4	474	49	intermediate	intermediate	JJ
cord-307860-iqk1yiw4	474	50	animal	animal	NN
cord-307860-iqk1yiw4	474	51	host	host	NN
cord-307860-iqk1yiw4	474	52	,	,	,
cord-307860-iqk1yiw4	474	53	and	and	CC
cord-307860-iqk1yiw4	474	54	cross	cross	JJ
cord-307860-iqk1yiw4	474	55	-	-	JJ
cord-307860-iqk1yiw4	474	56	species	species	JJ
cord-307860-iqk1yiw4	474	57	analyses	analysis	NNS
cord-307860-iqk1yiw4	474	58	of	of	IN
cord-307860-iqk1yiw4	474	59	SARS	SARS	NNP
cord-307860-iqk1yiw4	474	60	-	-	HYPH
cord-307860-iqk1yiw4	474	61	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	474	62	Middle	Middle	NNP
cord-307860-iqk1yiw4	474	63	East	East	NNP
cord-307860-iqk1yiw4	474	64	Respiratory	respiratory	JJ
cord-307860-iqk1yiw4	474	65	syndrome	syndrome	NN
cord-307860-iqk1yiw4	474	66	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	474	67	:	:	:
cord-307860-iqk1yiw4	474	68	another	another	DT
cord-307860-iqk1yiw4	474	69	zoonotic	zoonotic	JJ
cord-307860-iqk1yiw4	474	70	betacoronavirus	betacoronavirus	NN
cord-307860-iqk1yiw4	474	71	causing	cause	VBG
cord-307860-iqk1yiw4	474	72	SARS	SARS	NNP
cord-307860-iqk1yiw4	474	73	-	-	HYPH
cord-307860-iqk1yiw4	474	74	like	like	JJ
cord-307860-iqk1yiw4	474	75	disease	disease	NN
cord-307860-iqk1yiw4	475	1	A	a	DT
cord-307860-iqk1yiw4	475	2	SARSlike	sarslike	JJ
cord-307860-iqk1yiw4	475	3	cluster	cluster	NN
cord-307860-iqk1yiw4	475	4	of	of	IN
cord-307860-iqk1yiw4	475	5	circulating	circulate	VBG
cord-307860-iqk1yiw4	475	6	bat	bat	NN
cord-307860-iqk1yiw4	475	7	coronaviruses	coronaviruse	NNS
cord-307860-iqk1yiw4	475	8	shows	show	VBZ
cord-307860-iqk1yiw4	475	9	potential	potential	NN
cord-307860-iqk1yiw4	475	10	for	for	IN
cord-307860-iqk1yiw4	475	11	human	human	JJ
cord-307860-iqk1yiw4	475	12	emergence	emergence	NN
cord-307860-iqk1yiw4	475	13	MERS	MERS	NNP
cord-307860-iqk1yiw4	475	14	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	475	15	:	:	:
cord-307860-iqk1yiw4	475	16	diagnostics	diagnostic	NNS
cord-307860-iqk1yiw4	475	17	,	,	,
cord-307860-iqk1yiw4	475	18	epidemiology	epidemiology	NN
cord-307860-iqk1yiw4	475	19	and	and	CC
cord-307860-iqk1yiw4	475	20	transmission	transmission	NN
cord-307860-iqk1yiw4	475	21	Bat	bat	NN
cord-307860-iqk1yiw4	475	22	origins	origin	NNS
cord-307860-iqk1yiw4	475	23	of	of	IN
cord-307860-iqk1yiw4	475	24	MERS	MERS	NNP
cord-307860-iqk1yiw4	475	25	-	-	HYPH
cord-307860-iqk1yiw4	475	26	CoV	CoV	NNP
cord-307860-iqk1yiw4	475	27	supported	support	VBN
cord-307860-iqk1yiw4	475	28	by	by	IN
cord-307860-iqk1yiw4	475	29	bat	bat	NN
cord-307860-iqk1yiw4	475	30	Coronavirus	Coronavirus	NNP
cord-307860-iqk1yiw4	475	31	HKU4	HKU4	NNP
cord-307860-iqk1yiw4	475	32	usage	usage	NN
cord-307860-iqk1yiw4	475	33	of	of	IN
cord-307860-iqk1yiw4	475	34	human	human	JJ
cord-307860-iqk1yiw4	475	35	receptor	receptor	NN
cord-307860-iqk1yiw4	476	1	CD26	CD26	NNP
cord-307860-iqk1yiw4	476	2	SARS	SARS	NNP
cord-307860-iqk1yiw4	476	3	-	-	HYPH
cord-307860-iqk1yiw4	476	4	unique	unique	JJ
cord-307860-iqk1yiw4	476	5	fold	fold	NN
cord-307860-iqk1yiw4	476	6	in	in	IN
cord-307860-iqk1yiw4	476	7	the	the	DT
cord-307860-iqk1yiw4	476	8	Rousettus	Rousettus	NNP
cord-307860-iqk1yiw4	476	9	bat	bat	NN
cord-307860-iqk1yiw4	476	10	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	477	1	HKU9	HKU9	NNP
cord-307860-iqk1yiw4	477	2	Ligand	Ligand	NNP
cord-307860-iqk1yiw4	477	3	-	-	HYPH
cord-307860-iqk1yiw4	477	4	centered	center	VBN
cord-307860-iqk1yiw4	477	5	assessment	assessment	NN
cord-307860-iqk1yiw4	477	6	of	of	IN
cord-307860-iqk1yiw4	477	7	SARS	SARS	NNP
cord-307860-iqk1yiw4	477	8	-	-	HYPH
cord-307860-iqk1yiw4	477	9	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	477	10	drug	drug	NN
cord-307860-iqk1yiw4	477	11	target	target	NN
cord-307860-iqk1yiw4	477	12	models	model	NNS
cord-307860-iqk1yiw4	477	13	in	in	IN
cord-307860-iqk1yiw4	477	14	the	the	DT
cord-307860-iqk1yiw4	477	15	Protein	Protein	NNP
cord-307860-iqk1yiw4	477	16	Data	Data	NNP
cord-307860-iqk1yiw4	477	17	Bank	Bank	NNP
cord-307860-iqk1yiw4	477	18	A	a	DT
cord-307860-iqk1yiw4	477	19	highly	highly	RB
cord-307860-iqk1yiw4	477	20	conserved	conserved	JJ
cord-307860-iqk1yiw4	477	21	cryptic	cryptic	JJ
cord-307860-iqk1yiw4	477	22	epitope	epitope	NN
cord-307860-iqk1yiw4	477	23	in	in	IN
cord-307860-iqk1yiw4	477	24	the	the	DT
cord-307860-iqk1yiw4	477	25	receptor	receptor	NN
cord-307860-iqk1yiw4	477	26	binding	bind	VBG
cord-307860-iqk1yiw4	477	27	domains	domain	NNS
cord-307860-iqk1yiw4	477	28	of	of	IN
cord-307860-iqk1yiw4	477	29	SARS	SARS	NNP
cord-307860-iqk1yiw4	477	30	-	-	HYPH
cord-307860-iqk1yiw4	477	31	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	477	32	and	and	CC
cord-307860-iqk1yiw4	477	33	SARS	SARS	NNP
cord-307860-iqk1yiw4	477	34	-	-	HYPH
cord-307860-iqk1yiw4	477	35	CoV	CoV	NNP
cord-307860-iqk1yiw4	477	36	Neutralization	neutralization	NN
cord-307860-iqk1yiw4	477	37	of	of	IN
cord-307860-iqk1yiw4	477	38	SARS	SARS	NNP
cord-307860-iqk1yiw4	477	39	-	-	HYPH
cord-307860-iqk1yiw4	477	40	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	477	41	by	by	IN
cord-307860-iqk1yiw4	477	42	destruction	destruction	NN
cord-307860-iqk1yiw4	477	43	of	of	IN
cord-307860-iqk1yiw4	477	44	the	the	DT
cord-307860-iqk1yiw4	477	45	prefusion	prefusion	NN
cord-307860-iqk1yiw4	477	46	spike	spike	NN
cord-307860-iqk1yiw4	477	47	Potent	potent	JJ
cord-307860-iqk1yiw4	477	48	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	477	49	antibodies	antibody	NNS
cord-307860-iqk1yiw4	477	50	directed	direct	VBN
cord-307860-iqk1yiw4	477	51	to	to	IN
cord-307860-iqk1yiw4	477	52	multiple	multiple	JJ
cord-307860-iqk1yiw4	477	53	epitopes	epitope	NNS
cord-307860-iqk1yiw4	477	54	on	on	IN
cord-307860-iqk1yiw4	477	55	SARS	SARS	NNP
cord-307860-iqk1yiw4	477	56	-	-	HYPH
cord-307860-iqk1yiw4	477	57	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	477	58	spike	spike	NN
cord-307860-iqk1yiw4	477	59	Structural	structural	JJ
cord-307860-iqk1yiw4	477	60	basis	basis	NN
cord-307860-iqk1yiw4	477	61	for	for	IN
cord-307860-iqk1yiw4	477	62	neutralization	neutralization	NN
cord-307860-iqk1yiw4	477	63	of	of	IN
cord-307860-iqk1yiw4	477	64	SARS	SARS	NNP
cord-307860-iqk1yiw4	477	65	-	-	HYPH
cord-307860-iqk1yiw4	477	66	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	477	67	and	and	CC
cord-307860-iqk1yiw4	477	68	SARS	SARS	NNP
cord-307860-iqk1yiw4	477	69	-	-	HYPH
cord-307860-iqk1yiw4	477	70	CoV	CoV	NNP
cord-307860-iqk1yiw4	477	71	by	by	IN
cord-307860-iqk1yiw4	477	72	a	a	DT
cord-307860-iqk1yiw4	477	73	potent	potent	JJ
cord-307860-iqk1yiw4	477	74	therapeutic	therapeutic	JJ
cord-307860-iqk1yiw4	477	75	antibody	antibody	NN
cord-307860-iqk1yiw4	478	1	A	a	DT
cord-307860-iqk1yiw4	478	2	noncompeting	noncompeting	JJ
cord-307860-iqk1yiw4	478	3	pair	pair	NN
cord-307860-iqk1yiw4	478	4	of	of	IN
cord-307860-iqk1yiw4	478	5	human	human	JJ
cord-307860-iqk1yiw4	478	6	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	478	7	antibodies	antibody	NNS
cord-307860-iqk1yiw4	478	8	block	block	VBP
cord-307860-iqk1yiw4	478	9	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	478	10	virus	virus	NN
cord-307860-iqk1yiw4	478	11	binding	bind	VBG
cord-307860-iqk1yiw4	478	12	to	to	IN
cord-307860-iqk1yiw4	479	1	its	-PRON-	PRP$
cord-307860-iqk1yiw4	479	2	receptor	receptor	NN
cord-307860-iqk1yiw4	479	3	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	479	4	A	a	DT
cord-307860-iqk1yiw4	479	5	human	human	JJ
cord-307860-iqk1yiw4	479	6	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	479	7	antibody	antibody	NN
cord-307860-iqk1yiw4	479	8	targets	target	VBZ
cord-307860-iqk1yiw4	479	9	the	the	DT
cord-307860-iqk1yiw4	479	10	receptor	receptor	NN
cord-307860-iqk1yiw4	479	11	binding	bind	VBG
cord-307860-iqk1yiw4	479	12	site	site	NN
cord-307860-iqk1yiw4	479	13	of	of	IN
cord-307860-iqk1yiw4	479	14	SARS	SARS	NNP
cord-307860-iqk1yiw4	479	15	-	-	HYPH
cord-307860-iqk1yiw4	479	16	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	479	17	Human	Human	NNP
cord-307860-iqk1yiw4	479	18	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	479	19	antibodies	antibody	NNS
cord-307860-iqk1yiw4	479	20	elicited	elicit	VBN
cord-307860-iqk1yiw4	479	21	by	by	IN
cord-307860-iqk1yiw4	479	22	SARS	SARS	NNP
cord-307860-iqk1yiw4	479	23	-	-	HYPH
cord-307860-iqk1yiw4	479	24	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	479	25	infection	infection	NN
cord-307860-iqk1yiw4	479	26	Potent	potent	JJ
cord-307860-iqk1yiw4	479	27	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	479	28	antibodies	antibody	NNS
cord-307860-iqk1yiw4	479	29	against	against	IN
cord-307860-iqk1yiw4	479	30	SARS	SARS	NNP
cord-307860-iqk1yiw4	479	31	-	-	HYPH
cord-307860-iqk1yiw4	479	32	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	479	33	identified	identify	VBN
cord-307860-iqk1yiw4	479	34	by	by	IN
cord-307860-iqk1yiw4	479	35	high	high	JJ
cord-307860-iqk1yiw4	479	36	-	-	HYPH
cord-307860-iqk1yiw4	479	37	throughput	throughput	NN
cord-307860-iqk1yiw4	479	38	single	single	JJ
cord-307860-iqk1yiw4	479	39	-	-	HYPH
cord-307860-iqk1yiw4	479	40	cell	cell	NN
cord-307860-iqk1yiw4	479	41	sequencing	sequencing	NN
cord-307860-iqk1yiw4	479	42	of	of	IN
cord-307860-iqk1yiw4	479	43	convalescent	convalescent	JJ
cord-307860-iqk1yiw4	479	44	patients	patient	NNS
cord-307860-iqk1yiw4	479	45	'	'	POS
cord-307860-iqk1yiw4	479	46	B	b	NN
cord-307860-iqk1yiw4	479	47	cells	cell	NNS
cord-307860-iqk1yiw4	479	48	Structural	structural	JJ
cord-307860-iqk1yiw4	479	49	basis	basis	NN
cord-307860-iqk1yiw4	479	50	for	for	IN
cord-307860-iqk1yiw4	479	51	the	the	DT
cord-307860-iqk1yiw4	479	52	neutralization	neutralization	NN
cord-307860-iqk1yiw4	479	53	of	of	IN
cord-307860-iqk1yiw4	479	54	SARS	SARS	NNP
cord-307860-iqk1yiw4	479	55	-	-	HYPH
cord-307860-iqk1yiw4	479	56	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	479	57	by	by	IN
cord-307860-iqk1yiw4	479	58	an	an	DT
cord-307860-iqk1yiw4	479	59	antibody	antibody	NN
cord-307860-iqk1yiw4	479	60	from	from	IN
cord-307860-iqk1yiw4	479	61	a	a	DT
cord-307860-iqk1yiw4	479	62	convalescent	convalescent	JJ
cord-307860-iqk1yiw4	479	63	patient	patient	NN
cord-307860-iqk1yiw4	479	64	Studies	study	NNS
cord-307860-iqk1yiw4	479	65	in	in	IN
cord-307860-iqk1yiw4	479	66	humanized	humanized	JJ
cord-307860-iqk1yiw4	479	67	mice	mouse	NNS
cord-307860-iqk1yiw4	479	68	and	and	CC
cord-307860-iqk1yiw4	480	1	convalescent	convalescent	JJ
cord-307860-iqk1yiw4	480	2	humans	human	NNS
cord-307860-iqk1yiw4	480	3	yield	yield	VBP
cord-307860-iqk1yiw4	480	4	a	a	DT
cord-307860-iqk1yiw4	480	5	SARS	SARS	NNP
cord-307860-iqk1yiw4	480	6	-	-	HYPH
cord-307860-iqk1yiw4	480	7	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	480	8	antibody	antibody	NN
cord-307860-iqk1yiw4	480	9	cocktail	cocktail	NN
cord-307860-iqk1yiw4	480	10	Structures	structure	NNS
cord-307860-iqk1yiw4	480	11	of	of	IN
cord-307860-iqk1yiw4	480	12	human	human	JJ
cord-307860-iqk1yiw4	480	13	antibodies	antibody	NNS
cord-307860-iqk1yiw4	480	14	bound	bind	VBN
cord-307860-iqk1yiw4	480	15	to	to	IN
cord-307860-iqk1yiw4	480	16	SARS	SARS	NNP
cord-307860-iqk1yiw4	480	17	-	-	HYPH
cord-307860-iqk1yiw4	480	18	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	480	19	spike	spike	NN
cord-307860-iqk1yiw4	480	20	reveal	reveal	VBP
cord-307860-iqk1yiw4	481	1	common	common	JJ
cord-307860-iqk1yiw4	481	2	epitopes	epitope	NNS
cord-307860-iqk1yiw4	481	3	and	and	CC
cord-307860-iqk1yiw4	481	4	recurrent	recurrent	JJ
cord-307860-iqk1yiw4	481	5	features	feature	NNS
cord-307860-iqk1yiw4	481	6	of	of	IN
cord-307860-iqk1yiw4	481	7	antibodies	antibody	NNS
cord-307860-iqk1yiw4	481	8	A	a	DT
cord-307860-iqk1yiw4	481	9	neutralizing	neutralize	VBG
cord-307860-iqk1yiw4	481	10	human	human	JJ
cord-307860-iqk1yiw4	481	11	antibody	antibody	NN
cord-307860-iqk1yiw4	481	12	binds	bind	VBZ
cord-307860-iqk1yiw4	481	13	to	to	IN
cord-307860-iqk1yiw4	481	14	the	the	DT
cord-307860-iqk1yiw4	481	15	N	n	CD
cord-307860-iqk1yiw4	481	16	-	-	HYPH
cord-307860-iqk1yiw4	481	17	terminal	terminal	NN
cord-307860-iqk1yiw4	481	18	domain	domain	NN
cord-307860-iqk1yiw4	481	19	of	of	IN
cord-307860-iqk1yiw4	481	20	the	the	DT
cord-307860-iqk1yiw4	481	21	spike	spike	NN
cord-307860-iqk1yiw4	481	22	protein	protein	NN
cord-307860-iqk1yiw4	481	23	of	of	IN
cord-307860-iqk1yiw4	481	24	SARS	SARS	NNP
cord-307860-iqk1yiw4	481	25	-	-	HYPH
cord-307860-iqk1yiw4	481	26	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	481	27	Automated	automate	VBN
cord-307860-iqk1yiw4	481	28	docking	docking	NN
cord-307860-iqk1yiw4	481	29	of	of	IN
cord-307860-iqk1yiw4	481	30	substrates	substrate	NNS
cord-307860-iqk1yiw4	481	31	to	to	IN
cord-307860-iqk1yiw4	481	32	proteins	protein	NNS
cord-307860-iqk1yiw4	481	33	by	by	IN
cord-307860-iqk1yiw4	481	34	simulated	simulated	JJ
cord-307860-iqk1yiw4	481	35	annealing	annealing	NN
cord-307860-iqk1yiw4	481	36	AutoDockFR	AutoDockFR	NNS
cord-307860-iqk1yiw4	481	37	:	:	:
cord-307860-iqk1yiw4	481	38	advances	advance	NNS
cord-307860-iqk1yiw4	481	39	in	in	IN
cord-307860-iqk1yiw4	481	40	protein	protein	NN
cord-307860-iqk1yiw4	481	41	-	-	HYPH
cord-307860-iqk1yiw4	481	42	ligand	ligand	NN
cord-307860-iqk1yiw4	481	43	docking	docking	NN
cord-307860-iqk1yiw4	481	44	with	with	IN
cord-307860-iqk1yiw4	481	45	explicitly	explicitly	RB
cord-307860-iqk1yiw4	481	46	specified	specify	VBN
cord-307860-iqk1yiw4	481	47	binding	binding	NN
cord-307860-iqk1yiw4	481	48	site	site	NN
cord-307860-iqk1yiw4	481	49	flexibility	flexibility	NN
cord-307860-iqk1yiw4	481	50	A	a	DT
cord-307860-iqk1yiw4	481	51	simple	simple	JJ
cord-307860-iqk1yiw4	481	52	click	click	NN
cord-307860-iqk1yiw4	481	53	by	by	IN
cord-307860-iqk1yiw4	481	54	click	click	NN
cord-307860-iqk1yiw4	481	55	protocol	protocol	NN
cord-307860-iqk1yiw4	481	56	to	to	TO
cord-307860-iqk1yiw4	481	57	perform	perform	VB
cord-307860-iqk1yiw4	481	58	docking	docking	NN
cord-307860-iqk1yiw4	482	1	:	:	:
cord-307860-iqk1yiw4	482	2	autoDock	autodock	NN
cord-307860-iqk1yiw4	482	3	4.2	4.2	CD
cord-307860-iqk1yiw4	482	4	made	make	VBD
cord-307860-iqk1yiw4	482	5	easy	easy	JJ
cord-307860-iqk1yiw4	482	6	for	for	IN
cord-307860-iqk1yiw4	482	7	nonbioinformaticians	nonbioinformaticians	NNP
cord-307860-iqk1yiw4	482	8	Inhibition	Inhibition	NNP
cord-307860-iqk1yiw4	482	9	of	of	IN
cord-307860-iqk1yiw4	482	10	SARS	SARS	NNP
cord-307860-iqk1yiw4	482	11	-	-	HYPH
cord-307860-iqk1yiw4	482	12	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	482	13	(	(	-LRB-
cord-307860-iqk1yiw4	482	14	previously	previously	RB
cord-307860-iqk1yiw4	482	15	2019-nCoV	2019-ncov	CD
cord-307860-iqk1yiw4	482	16	)	)	-RRB-
cord-307860-iqk1yiw4	482	17	infection	infection	NN
cord-307860-iqk1yiw4	482	18	by	by	IN
cord-307860-iqk1yiw4	482	19	a	a	DT
cord-307860-iqk1yiw4	482	20	highly	highly	RB
cord-307860-iqk1yiw4	482	21	potent	potent	JJ
cord-307860-iqk1yiw4	482	22	pan	pan	JJ
cord-307860-iqk1yiw4	482	23	-	-	JJ
cord-307860-iqk1yiw4	482	24	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	482	25	fusion	fusion	NN
cord-307860-iqk1yiw4	482	26	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	482	27	targeting	target	VBG
cord-307860-iqk1yiw4	482	28	its	-PRON-	PRP$
cord-307860-iqk1yiw4	482	29	spike	spike	NN
cord-307860-iqk1yiw4	482	30	protein	protein	NN
cord-307860-iqk1yiw4	482	31	that	that	WDT
cord-307860-iqk1yiw4	482	32	harbors	harbor	VBZ
cord-307860-iqk1yiw4	482	33	a	a	DT
cord-307860-iqk1yiw4	482	34	high	high	JJ
cord-307860-iqk1yiw4	482	35	capacity	capacity	NN
cord-307860-iqk1yiw4	482	36	to	to	TO
cord-307860-iqk1yiw4	482	37	mediate	mediate	VB
cord-307860-iqk1yiw4	482	38	membrane	membrane	NN
cord-307860-iqk1yiw4	482	39	fusion	fusion	NN
cord-307860-iqk1yiw4	482	40	Structure	structure	NN
cord-307860-iqk1yiw4	482	41	,	,	,
cord-307860-iqk1yiw4	482	42	function	function	NN
cord-307860-iqk1yiw4	482	43	,	,	,
cord-307860-iqk1yiw4	482	44	and	and	CC
cord-307860-iqk1yiw4	482	45	antigenicity	antigenicity	NN
cord-307860-iqk1yiw4	482	46	of	of	IN
cord-307860-iqk1yiw4	482	47	the	the	DT
cord-307860-iqk1yiw4	482	48	SARS	SARS	NNP
cord-307860-iqk1yiw4	482	49	-	-	HYPH
cord-307860-iqk1yiw4	482	50	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	482	51	spike	spike	NN
cord-307860-iqk1yiw4	482	52	glycoprotein	glycoprotein	NN
cord-307860-iqk1yiw4	482	53	Structure	structure	NN
cord-307860-iqk1yiw4	482	54	of	of	IN
cord-307860-iqk1yiw4	482	55	the	the	DT
cord-307860-iqk1yiw4	482	56	RNAdependent	RNAdependent	NNP
cord-307860-iqk1yiw4	482	57	RNA	RNA	NNP
cord-307860-iqk1yiw4	482	58	polymerase	polymerase	NN
cord-307860-iqk1yiw4	482	59	from	from	IN
cord-307860-iqk1yiw4	482	60	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	482	61	virus	virus	NN
cord-307860-iqk1yiw4	482	62	Structure	Structure	NNP
cord-307860-iqk1yiw4	482	63	of	of	IN
cord-307860-iqk1yiw4	482	64	the	the	DT
cord-307860-iqk1yiw4	482	65	SARS	SARS	NNP
cord-307860-iqk1yiw4	482	66	-	-	HYPH
cord-307860-iqk1yiw4	482	67	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	482	68	spike	spike	NN
cord-307860-iqk1yiw4	482	69	receptor	receptor	NN
cord-307860-iqk1yiw4	482	70	-	-	HYPH
cord-307860-iqk1yiw4	482	71	binding	bind	VBG
cord-307860-iqk1yiw4	482	72	domain	domain	NN
cord-307860-iqk1yiw4	482	73	bound	bind	VBN
cord-307860-iqk1yiw4	482	74	to	to	IN
cord-307860-iqk1yiw4	482	75	the	the	DT
cord-307860-iqk1yiw4	482	76	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	482	77	receptor	receptor	NN
cord-307860-iqk1yiw4	482	78	Crystal	Crystal	NNP
cord-307860-iqk1yiw4	482	79	structure	structure	NN
cord-307860-iqk1yiw4	482	80	of	of	IN
cord-307860-iqk1yiw4	482	81	SARS	SARS	NNP
cord-307860-iqk1yiw4	482	82	-	-	HYPH
cord-307860-iqk1yiw4	482	83	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	482	84	nucleocapsid	nucleocapsid	NN
cord-307860-iqk1yiw4	482	85	protein	protein	NN
cord-307860-iqk1yiw4	482	86	RNA	RNA	NNP
cord-307860-iqk1yiw4	482	87	binding	bind	VBG
cord-307860-iqk1yiw4	482	88	domain	domain	NN
cord-307860-iqk1yiw4	482	89	reveals	reveal	VBZ
cord-307860-iqk1yiw4	482	90	potential	potential	JJ
cord-307860-iqk1yiw4	482	91	unique	unique	JJ
cord-307860-iqk1yiw4	482	92	drug	drug	NN
cord-307860-iqk1yiw4	482	93	targeting	target	VBG
cord-307860-iqk1yiw4	482	94	sites	site	NNS
cord-307860-iqk1yiw4	482	95	Crystal	Crystal	NNP
cord-307860-iqk1yiw4	482	96	structure	structure	NN
cord-307860-iqk1yiw4	482	97	of	of	IN
cord-307860-iqk1yiw4	482	98	Nsp15	Nsp15	NNP
cord-307860-iqk1yiw4	482	99	endoribonuclease	endoribonuclease	NN
cord-307860-iqk1yiw4	482	100	NendoU	NendoU	NNP
cord-307860-iqk1yiw4	482	101	from	from	IN
cord-307860-iqk1yiw4	482	102	SARS	SARS	NNP
cord-307860-iqk1yiw4	482	103	-	-	HYPH
cord-307860-iqk1yiw4	482	104	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	482	105	Cryo	Cryo	NNP
cord-307860-iqk1yiw4	482	106	-	-	HYPH
cord-307860-iqk1yiw4	482	107	EM	EM	NNP
cord-307860-iqk1yiw4	482	108	structure	structure	NN
cord-307860-iqk1yiw4	482	109	of	of	IN
cord-307860-iqk1yiw4	482	110	the	the	DT
cord-307860-iqk1yiw4	482	111	2019-nCoV	2019-ncov	CD
cord-307860-iqk1yiw4	482	112	spike	spike	NN
cord-307860-iqk1yiw4	482	113	in	in	IN
cord-307860-iqk1yiw4	482	114	the	the	DT
cord-307860-iqk1yiw4	482	115	prefusion	prefusion	NN
cord-307860-iqk1yiw4	482	116	conformation	conformation	NN
cord-307860-iqk1yiw4	482	117	Structural	structural	JJ
cord-307860-iqk1yiw4	482	118	and	and	CC
cord-307860-iqk1yiw4	482	119	functional	functional	JJ
cord-307860-iqk1yiw4	482	120	basis	basis	NN
cord-307860-iqk1yiw4	482	121	of	of	IN
cord-307860-iqk1yiw4	482	122	SARS	SARS	NNP
cord-307860-iqk1yiw4	482	123	-	-	HYPH
cord-307860-iqk1yiw4	482	124	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	482	125	entry	entry	NN
cord-307860-iqk1yiw4	482	126	by	by	IN
cord-307860-iqk1yiw4	482	127	using	use	VBG
cord-307860-iqk1yiw4	482	128	human	human	JJ
cord-307860-iqk1yiw4	482	129	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	482	130	Structural	structural	JJ
cord-307860-iqk1yiw4	482	131	basis	basis	NN
cord-307860-iqk1yiw4	482	132	for	for	IN
cord-307860-iqk1yiw4	482	133	inhibition	inhibition	NN
cord-307860-iqk1yiw4	482	134	of	of	IN
cord-307860-iqk1yiw4	482	135	the	the	DT
cord-307860-iqk1yiw4	482	136	RNA	RNA	NNP
cord-307860-iqk1yiw4	482	137	-	-	HYPH
cord-307860-iqk1yiw4	482	138	dependent	dependent	JJ
cord-307860-iqk1yiw4	482	139	RNA	RNA	NNP
cord-307860-iqk1yiw4	482	140	polymerase	polymerase	NN
cord-307860-iqk1yiw4	482	141	from	from	IN
cord-307860-iqk1yiw4	482	142	SARS	SARS	NNP
cord-307860-iqk1yiw4	482	143	-	-	HYPH
cord-307860-iqk1yiw4	482	144	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	482	145	by	by	IN
cord-307860-iqk1yiw4	482	146	remdesivir	remdesivir	NNP
cord-307860-iqk1yiw4	482	147	Structure	Structure	NNP
cord-307860-iqk1yiw4	482	148	of	of	IN
cord-307860-iqk1yiw4	482	149	replicating	replicate	VBG
cord-307860-iqk1yiw4	482	150	SARS	SARS	NNP
cord-307860-iqk1yiw4	482	151	-	-	HYPH
cord-307860-iqk1yiw4	482	152	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	482	153	polymerase	polymerase	NN
cord-307860-iqk1yiw4	482	154	Structural	structural	JJ
cord-307860-iqk1yiw4	482	155	basis	basis	NN
cord-307860-iqk1yiw4	482	156	for	for	IN
cord-307860-iqk1yiw4	482	157	the	the	DT
cord-307860-iqk1yiw4	482	158	recognition	recognition	NN
cord-307860-iqk1yiw4	482	159	of	of	IN
cord-307860-iqk1yiw4	482	160	SARS	SARS	NNP
cord-307860-iqk1yiw4	482	161	-	-	HYPH
cord-307860-iqk1yiw4	482	162	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	482	163	by	by	IN
cord-307860-iqk1yiw4	482	164	full	full	JJ
cord-307860-iqk1yiw4	482	165	-	-	HYPH
cord-307860-iqk1yiw4	482	166	length	length	NN
cord-307860-iqk1yiw4	482	167	human	human	JJ
cord-307860-iqk1yiw4	482	168	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	482	169	Distinct	Distinct	NNP
cord-307860-iqk1yiw4	482	170	conformational	conformational	JJ
cord-307860-iqk1yiw4	482	171	states	state	NNS
cord-307860-iqk1yiw4	482	172	of	of	IN
cord-307860-iqk1yiw4	482	173	SARS	SARS	NNP
cord-307860-iqk1yiw4	482	174	-	-	HYPH
cord-307860-iqk1yiw4	482	175	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	482	176	spike	spike	NN
cord-307860-iqk1yiw4	482	177	protein	protein	NN
cord-307860-iqk1yiw4	482	178	.	.	.
cord-307860-iqk1yiw4	483	1	Science	Science	NNP
cord-307860-iqk1yiw4	483	2	80-:eabd4251	80-:eabd4251	NNP
cord-307860-iqk1yiw4	483	3	Structure	Structure	NNP
cord-307860-iqk1yiw4	483	4	of	of	IN
cord-307860-iqk1yiw4	483	5	Mpro	Mpro	NNP
cord-307860-iqk1yiw4	483	6	from	from	IN
cord-307860-iqk1yiw4	483	7	SARS	SARS	NNP
cord-307860-iqk1yiw4	483	8	-	-	HYPH
cord-307860-iqk1yiw4	483	9	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	483	10	and	and	CC
cord-307860-iqk1yiw4	483	11	discovery	discovery	NN
cord-307860-iqk1yiw4	483	12	of	of	IN
cord-307860-iqk1yiw4	483	13	its	-PRON-	PRP$
cord-307860-iqk1yiw4	483	14	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	483	15	Structure	Structure	NNP
cord-307860-iqk1yiw4	483	16	-	-	HYPH
cord-307860-iqk1yiw4	483	17	based	base	VBN
cord-307860-iqk1yiw4	483	18	design	design	NN
cord-307860-iqk1yiw4	483	19	of	of	IN
cord-307860-iqk1yiw4	483	20	antiviral	antiviral	JJ
cord-307860-iqk1yiw4	483	21	drug	drug	NN
cord-307860-iqk1yiw4	483	22	candidates	candidate	NNS
cord-307860-iqk1yiw4	483	23	targeting	target	VBG
cord-307860-iqk1yiw4	483	24	the	the	DT
cord-307860-iqk1yiw4	483	25	SARS	SARS	NNP
cord-307860-iqk1yiw4	483	26	-	-	HYPH
cord-307860-iqk1yiw4	483	27	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	483	28	main	main	JJ
cord-307860-iqk1yiw4	483	29	protease	protease	NN
cord-307860-iqk1yiw4	483	30	Structural	structural	JJ
cord-307860-iqk1yiw4	483	31	basis	basis	NN
cord-307860-iqk1yiw4	483	32	for	for	IN
cord-307860-iqk1yiw4	483	33	the	the	DT
cord-307860-iqk1yiw4	483	34	inhibition	inhibition	NN
cord-307860-iqk1yiw4	483	35	of	of	IN
cord-307860-iqk1yiw4	483	36	SARS	SARS	NNP
cord-307860-iqk1yiw4	483	37	-	-	HYPH
cord-307860-iqk1yiw4	483	38	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	483	39	main	main	JJ
cord-307860-iqk1yiw4	483	40	protease	protease	NN
cord-307860-iqk1yiw4	483	41	by	by	IN
cord-307860-iqk1yiw4	483	42	antineoplastic	antineoplastic	JJ
cord-307860-iqk1yiw4	483	43	drug	drug	NN
cord-307860-iqk1yiw4	483	44	carmofur	carmofur	NNP
cord-307860-iqk1yiw4	483	45	Crystal	Crystal	NNP
cord-307860-iqk1yiw4	483	46	structure	structure	NN
cord-307860-iqk1yiw4	483	47	of	of	IN
cord-307860-iqk1yiw4	483	48	SARS	SARS	NNP
cord-307860-iqk1yiw4	483	49	-	-	HYPH
cord-307860-iqk1yiw4	483	50	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	483	51	main	main	JJ
cord-307860-iqk1yiw4	483	52	protease	protease	NN
cord-307860-iqk1yiw4	483	53	provides	provide	VBZ
cord-307860-iqk1yiw4	483	54	a	a	DT
cord-307860-iqk1yiw4	483	55	basis	basis	NN
cord-307860-iqk1yiw4	483	56	for	for	IN
cord-307860-iqk1yiw4	483	57	design	design	NN
cord-307860-iqk1yiw4	483	58	of	of	IN
cord-307860-iqk1yiw4	483	59	improved	improve	VBN
cord-307860-iqk1yiw4	483	60	a	a	DT
cord-307860-iqk1yiw4	483	61	-	-	HYPH
cord-307860-iqk1yiw4	483	62	ketoamide	ketoamide	NN
cord-307860-iqk1yiw4	483	63	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	483	64	Structural	structural	JJ
cord-307860-iqk1yiw4	483	65	basis	basis	NN
cord-307860-iqk1yiw4	483	66	for	for	IN
cord-307860-iqk1yiw4	483	67	RNA	rna	NN
cord-307860-iqk1yiw4	483	68	replication	replication	NN
cord-307860-iqk1yiw4	483	69	by	by	IN
cord-307860-iqk1yiw4	483	70	the	the	DT
cord-307860-iqk1yiw4	483	71	SARS	SARS	NNP
cord-307860-iqk1yiw4	483	72	-	-	HYPH
cord-307860-iqk1yiw4	483	73	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	483	74	polymerase	polymerase	NN
cord-307860-iqk1yiw4	483	75	Structural	structural	JJ
cord-307860-iqk1yiw4	483	76	basis	basis	NN
cord-307860-iqk1yiw4	483	77	for	for	IN
cord-307860-iqk1yiw4	483	78	translational	translational	JJ
cord-307860-iqk1yiw4	483	79	shutdown	shutdown	NN
cord-307860-iqk1yiw4	483	80	and	and	CC
cord-307860-iqk1yiw4	483	81	immune	immune	JJ
cord-307860-iqk1yiw4	483	82	evasion	evasion	NN
cord-307860-iqk1yiw4	483	83	by	by	IN
cord-307860-iqk1yiw4	483	84	the	the	DT
cord-307860-iqk1yiw4	483	85	Nsp1	Nsp1	NNP
cord-307860-iqk1yiw4	483	86	protein	protein	NN
cord-307860-iqk1yiw4	483	87	of	of	IN
cord-307860-iqk1yiw4	483	88	SARS	SARS	NNP
cord-307860-iqk1yiw4	483	89	-	-	HYPH
cord-307860-iqk1yiw4	483	90	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	483	91	Structural	structural	JJ
cord-307860-iqk1yiw4	483	92	plasticity	plasticity	NN
cord-307860-iqk1yiw4	483	93	of	of	IN
cord-307860-iqk1yiw4	483	94	SARS	SARS	NNP
cord-307860-iqk1yiw4	483	95	-	-	HYPH
cord-307860-iqk1yiw4	483	96	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	483	97	3CL	3CL	NNP
cord-307860-iqk1yiw4	483	98	Mpro	Mpro	NNP
cord-307860-iqk1yiw4	483	99	active	active	JJ
cord-307860-iqk1yiw4	483	100	site	site	NN
cord-307860-iqk1yiw4	483	101	cavity	cavity	NN
cord-307860-iqk1yiw4	483	102	revealed	reveal	VBN
cord-307860-iqk1yiw4	483	103	by	by	IN
cord-307860-iqk1yiw4	483	104	room	room	NN
cord-307860-iqk1yiw4	483	105	temperature	temperature	NN
cord-307860-iqk1yiw4	483	106	X	x	NN
cord-307860-iqk1yiw4	483	107	-	-	NN
cord-307860-iqk1yiw4	483	108	ray	ray	NN
cord-307860-iqk1yiw4	483	109	crystallography	crystallography	NN
cord-307860-iqk1yiw4	483	110	Structural	structural	JJ
cord-307860-iqk1yiw4	483	111	and	and	CC
cord-307860-iqk1yiw4	483	112	biochemical	biochemical	JJ
cord-307860-iqk1yiw4	483	113	characterization	characterization	NN
cord-307860-iqk1yiw4	483	114	of	of	IN
cord-307860-iqk1yiw4	483	115	the	the	DT
cord-307860-iqk1yiw4	483	116	nsp12-nsp7-nsp8	nsp12-nsp7-nsp8	NNP
cord-307860-iqk1yiw4	483	117	core	core	NN
cord-307860-iqk1yiw4	483	118	polymerase	polymerase	NN
cord-307860-iqk1yiw4	483	119	complex	complex	NN
cord-307860-iqk1yiw4	483	120	from	from	IN
cord-307860-iqk1yiw4	483	121	SARS	SARS	NNP
cord-307860-iqk1yiw4	483	122	-	-	HYPH
cord-307860-iqk1yiw4	483	123	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	484	1	A	a	DT
cord-307860-iqk1yiw4	484	2	thermostable	thermostable	JJ
cord-307860-iqk1yiw4	484	3	,	,	,
cord-307860-iqk1yiw4	484	4	closed	closed	JJ
cord-307860-iqk1yiw4	484	5	SARS	SARS	NNP
cord-307860-iqk1yiw4	484	6	-	-	HYPH
cord-307860-iqk1yiw4	484	7	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	484	8	spike	spike	NN
cord-307860-iqk1yiw4	484	9	protein	protein	NN
cord-307860-iqk1yiw4	484	10	trimer	trimer	NN
cord-307860-iqk1yiw4	485	1	Papain	papain	NN
cord-307860-iqk1yiw4	485	2	-	-	HYPH
cord-307860-iqk1yiw4	485	3	like	like	JJ
cord-307860-iqk1yiw4	485	4	protease	protease	NN
cord-307860-iqk1yiw4	485	5	regulates	regulate	VBZ
cord-307860-iqk1yiw4	485	6	SARS	SARS	NNP
cord-307860-iqk1yiw4	485	7	-	-	HYPH
cord-307860-iqk1yiw4	485	8	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	485	9	viral	viral	JJ
cord-307860-iqk1yiw4	485	10	spread	spread	NN
cord-307860-iqk1yiw4	485	11	and	and	CC
cord-307860-iqk1yiw4	485	12	innate	innate	JJ
cord-307860-iqk1yiw4	485	13	immunity	immunity	NN
cord-307860-iqk1yiw4	486	1	Cinanserin	Cinanserin	NNP
cord-307860-iqk1yiw4	486	2	is	be	VBZ
cord-307860-iqk1yiw4	486	3	an	an	DT
cord-307860-iqk1yiw4	486	4	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	486	5	of	of	IN
cord-307860-iqk1yiw4	486	6	the	the	DT
cord-307860-iqk1yiw4	486	7	3C	3c	NN
cord-307860-iqk1yiw4	486	8	-	-	HYPH
cord-307860-iqk1yiw4	486	9	like	like	JJ
cord-307860-iqk1yiw4	486	10	proteinase	proteinase	NN
cord-307860-iqk1yiw4	486	11	of	of	IN
cord-307860-iqk1yiw4	486	12	severe	severe	JJ
cord-307860-iqk1yiw4	486	13	acute	acute	JJ
cord-307860-iqk1yiw4	486	14	respiratory	respiratory	JJ
cord-307860-iqk1yiw4	486	15	syndrome	syndrome	NN
cord-307860-iqk1yiw4	486	16	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	486	17	and	and	CC
cord-307860-iqk1yiw4	486	18	strongly	strongly	RB
cord-307860-iqk1yiw4	486	19	reduces	reduce	VBZ
cord-307860-iqk1yiw4	486	20	virus	virus	NN
cord-307860-iqk1yiw4	486	21	replication	replication	NN
cord-307860-iqk1yiw4	486	22	in	in	IN
cord-307860-iqk1yiw4	486	23	vitro	vitro	FW
cord-307860-iqk1yiw4	486	24	Recent	recent	JJ
cord-307860-iqk1yiw4	486	25	developments	development	NNS
cord-307860-iqk1yiw4	486	26	on	on	IN
cord-307860-iqk1yiw4	486	27	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	487	1	main	main	JJ
cord-307860-iqk1yiw4	487	2	protease/3C	protease/3C	NNP
cord-307860-iqk1yiw4	488	1	like	like	IN
cord-307860-iqk1yiw4	488	2	protease	protease	NN
cord-307860-iqk1yiw4	488	3	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	488	4	Production	production	NN
cord-307860-iqk1yiw4	488	5	of	of	IN
cord-307860-iqk1yiw4	488	6	authentic	authentic	JJ
cord-307860-iqk1yiw4	488	7	SARS	SARS	NNP
cord-307860-iqk1yiw4	488	8	-	-	HYPH
cord-307860-iqk1yiw4	488	9	CoV	CoV	NNP
cord-307860-iqk1yiw4	488	10	Mpro	Mpro	NNP
cord-307860-iqk1yiw4	488	11	with	with	IN
cord-307860-iqk1yiw4	488	12	enhanced	enhanced	JJ
cord-307860-iqk1yiw4	488	13	activity	activity	NN
cord-307860-iqk1yiw4	488	14	:	:	:
cord-307860-iqk1yiw4	488	15	application	application	NN
cord-307860-iqk1yiw4	488	16	as	as	IN
cord-307860-iqk1yiw4	488	17	a	a	DT
cord-307860-iqk1yiw4	488	18	novel	novel	JJ
cord-307860-iqk1yiw4	488	19	tag	tag	NN
cord-307860-iqk1yiw4	488	20	-	-	HYPH
cord-307860-iqk1yiw4	488	21	cleavage	cleavage	NN
cord-307860-iqk1yiw4	488	22	endopeptidase	endopeptidase	NN
cord-307860-iqk1yiw4	488	23	for	for	IN
cord-307860-iqk1yiw4	488	24	protein	protein	NN
cord-307860-iqk1yiw4	488	25	overproduction	overproduction	NN
cord-307860-iqk1yiw4	489	1	An	an	DT
cord-307860-iqk1yiw4	489	2	overview	overview	NN
cord-307860-iqk1yiw4	489	3	of	of	IN
cord-307860-iqk1yiw4	489	4	severe	severe	JJ
cord-307860-iqk1yiw4	489	5	acute	acute	JJ
cord-307860-iqk1yiw4	489	6	respiratory	respiratory	JJ
cord-307860-iqk1yiw4	489	7	syndrome	syndrome	NN
cord-307860-iqk1yiw4	489	8	-	-	HYPH
cord-307860-iqk1yiw4	489	9	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	489	10	(	(	-LRB-
cord-307860-iqk1yiw4	489	11	SARS	SARS	NNP
cord-307860-iqk1yiw4	489	12	-	-	HYPH
cord-307860-iqk1yiw4	489	13	CoV	CoV	NNP
cord-307860-iqk1yiw4	489	14	)	)	-RRB-
cord-307860-iqk1yiw4	489	15	3CL	3cl	CD
cord-307860-iqk1yiw4	489	16	protease	protease	NN
cord-307860-iqk1yiw4	489	17	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	489	18	:	:	:
cord-307860-iqk1yiw4	489	19	peptidomimetics	peptidomimetic	NNS
cord-307860-iqk1yiw4	489	20	and	and	CC
cord-307860-iqk1yiw4	489	21	small	small	JJ
cord-307860-iqk1yiw4	489	22	molecule	molecule	NN
cord-307860-iqk1yiw4	490	1	chemotherapy	chemotherapy	NN
cord-307860-iqk1yiw4	491	1	The	the	DT
cord-307860-iqk1yiw4	491	2	crystal	crystal	NN
cord-307860-iqk1yiw4	491	3	structures	structure	NNS
cord-307860-iqk1yiw4	491	4	of	of	IN
cord-307860-iqk1yiw4	491	5	severe	severe	JJ
cord-307860-iqk1yiw4	491	6	acute	acute	JJ
cord-307860-iqk1yiw4	491	7	respiratory	respiratory	JJ
cord-307860-iqk1yiw4	491	8	syndrome	syndrome	NN
cord-307860-iqk1yiw4	491	9	virus	virus	NN
cord-307860-iqk1yiw4	491	10	main	main	JJ
cord-307860-iqk1yiw4	491	11	protease	protease	NN
cord-307860-iqk1yiw4	491	12	and	and	CC
cord-307860-iqk1yiw4	491	13	its	-PRON-	PRP$
cord-307860-iqk1yiw4	491	14	complex	complex	NN
cord-307860-iqk1yiw4	491	15	with	with	IN
cord-307860-iqk1yiw4	491	16	an	an	DT
cord-307860-iqk1yiw4	491	17	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	491	18	X	x	NN
cord-307860-iqk1yiw4	491	19	-	-	NN
cord-307860-iqk1yiw4	491	20	ray	ray	NN
cord-307860-iqk1yiw4	491	21	structural	structural	JJ
cord-307860-iqk1yiw4	491	22	and	and	CC
cord-307860-iqk1yiw4	491	23	biological	biological	JJ
cord-307860-iqk1yiw4	491	24	evaluation	evaluation	NN
cord-307860-iqk1yiw4	491	25	of	of	IN
cord-307860-iqk1yiw4	491	26	a	a	DT
cord-307860-iqk1yiw4	491	27	series	series	NN
cord-307860-iqk1yiw4	491	28	of	of	IN
cord-307860-iqk1yiw4	491	29	potent	potent	JJ
cord-307860-iqk1yiw4	491	30	and	and	CC
cord-307860-iqk1yiw4	491	31	highly	highly	RB
cord-307860-iqk1yiw4	491	32	selective	selective	JJ
cord-307860-iqk1yiw4	491	33	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	491	34	of	of	IN
cord-307860-iqk1yiw4	491	35	human	human	JJ
cord-307860-iqk1yiw4	491	36	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	491	37	papain	papain	NN
cord-307860-iqk1yiw4	491	38	-	-	HYPH
cord-307860-iqk1yiw4	491	39	like	like	JJ
cord-307860-iqk1yiw4	491	40	proteases	protease	NNS
cord-307860-iqk1yiw4	491	41	Potential	potential	JJ
cord-307860-iqk1yiw4	491	42	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	491	43	against	against	IN
cord-307860-iqk1yiw4	491	44	2019-nCoV	2019-ncov	CD
cord-307860-iqk1yiw4	491	45	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	491	46	M	m	CD
cord-307860-iqk1yiw4	491	47	protease	protease	NN
cord-307860-iqk1yiw4	491	48	from	from	IN
cord-307860-iqk1yiw4	491	49	clinically	clinically	RB
cord-307860-iqk1yiw4	491	50	approved	approve	VBN
cord-307860-iqk1yiw4	491	51	medicines	medicine	NNS
cord-307860-iqk1yiw4	491	52	Targeting	target	VBG
cord-307860-iqk1yiw4	491	53	zoonotic	zoonotic	JJ
cord-307860-iqk1yiw4	491	54	viruses	virus	NNS
cord-307860-iqk1yiw4	491	55	:	:	:
cord-307860-iqk1yiw4	492	1	Structure	structure	NN
cord-307860-iqk1yiw4	492	2	-	-	HYPH
cord-307860-iqk1yiw4	492	3	based	base	VBN
cord-307860-iqk1yiw4	492	4	inhibition	inhibition	NN
cord-307860-iqk1yiw4	492	5	of	of	IN
cord-307860-iqk1yiw4	492	6	the	the	DT
cord-307860-iqk1yiw4	492	7	3C	3c	NN
cord-307860-iqk1yiw4	492	8	-	-	HYPH
cord-307860-iqk1yiw4	492	9	like	like	JJ
cord-307860-iqk1yiw4	492	10	protease	protease	NN
cord-307860-iqk1yiw4	492	11	from	from	IN
cord-307860-iqk1yiw4	492	12	bat	bat	NN
cord-307860-iqk1yiw4	492	13	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	492	14	HKU4	hku4	CD
cord-307860-iqk1yiw4	493	1	-The	-The	.
cord-307860-iqk1yiw4	494	1	likely	likely	RB
cord-307860-iqk1yiw4	494	2	reservoir	reservoir	NNP
cord-307860-iqk1yiw4	494	3	host	host	NN
cord-307860-iqk1yiw4	494	4	to	to	IN
cord-307860-iqk1yiw4	494	5	the	the	DT
cord-307860-iqk1yiw4	494	6	human	human	JJ
cord-307860-iqk1yiw4	494	7	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	494	8	that	that	WDT
cord-307860-iqk1yiw4	494	9	causes	cause	VBZ
cord-307860-iqk1yiw4	494	10	Middle	Middle	NNP
cord-307860-iqk1yiw4	494	11	East	East	NNP
cord-307860-iqk1yiw4	494	12	Respiratory	Respiratory	NNP
cord-307860-iqk1yiw4	494	13	Syndrome	Syndrome	NNP
cord-307860-iqk1yiw4	494	14	(	(	-LRB-
cord-307860-iqk1yiw4	494	15	MERS	MERS	NNP
cord-307860-iqk1yiw4	494	16	)	)	-RRB-
cord-307860-iqk1yiw4	495	1	Remdesivir	Remdesivir	NNP
cord-307860-iqk1yiw4	495	2	and	and	CC
cord-307860-iqk1yiw4	495	3	chloroquine	chloroquine	NN
cord-307860-iqk1yiw4	495	4	effectively	effectively	RB
cord-307860-iqk1yiw4	495	5	inhibit	inhibit	VBP
cord-307860-iqk1yiw4	495	6	the	the	DT
cord-307860-iqk1yiw4	495	7	recently	recently	RB
cord-307860-iqk1yiw4	495	8	emerged	emerge	VBN
cord-307860-iqk1yiw4	495	9	novel	novel	JJ
cord-307860-iqk1yiw4	495	10	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	495	11	(	(	-LRB-
cord-307860-iqk1yiw4	495	12	2019-nCoV	2019-ncov	CD
cord-307860-iqk1yiw4	495	13	)	)	-RRB-
cord-307860-iqk1yiw4	495	14	in	in	IN
cord-307860-iqk1yiw4	495	15	vitro	vitro	FW
cord-307860-iqk1yiw4	495	16	Alpha	alpha	NN
cord-307860-iqk1yiw4	495	17	-	-	HYPH
cord-307860-iqk1yiw4	495	18	ketoamides	ketoamides	NNP
cord-307860-iqk1yiw4	495	19	as	as	IN
cord-307860-iqk1yiw4	495	20	broad	broad	JJ
cord-307860-iqk1yiw4	495	21	-	-	HYPH
cord-307860-iqk1yiw4	495	22	spectrum	spectrum	NN
cord-307860-iqk1yiw4	495	23	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	495	24	of	of	IN
cord-307860-iqk1yiw4	495	25	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	495	26	and	and	CC
cord-307860-iqk1yiw4	495	27	enterovirus	enterovirus	NN
cord-307860-iqk1yiw4	495	28	replication	replication	NN
cord-307860-iqk1yiw4	495	29	:	:	:
cord-307860-iqk1yiw4	495	30	structure	structure	NN
cord-307860-iqk1yiw4	495	31	-	-	HYPH
cord-307860-iqk1yiw4	495	32	based	base	VBN
cord-307860-iqk1yiw4	495	33	design	design	NN
cord-307860-iqk1yiw4	495	34	,	,	,
cord-307860-iqk1yiw4	495	35	synthesis	synthesis	NN
cord-307860-iqk1yiw4	495	36	,	,	,
cord-307860-iqk1yiw4	495	37	and	and	CC
cord-307860-iqk1yiw4	495	38	activity	activity	NN
cord-307860-iqk1yiw4	495	39	assessment	assessment	NN
cord-307860-iqk1yiw4	495	40	Ebselen	Ebselen	NNP
cord-307860-iqk1yiw4	495	41	,	,	,
cord-307860-iqk1yiw4	495	42	a	a	DT
cord-307860-iqk1yiw4	495	43	small	small	JJ
cord-307860-iqk1yiw4	495	44	-	-	HYPH
cord-307860-iqk1yiw4	495	45	molecule	molecule	NN
cord-307860-iqk1yiw4	495	46	capsid	capsid	NN
cord-307860-iqk1yiw4	495	47	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	495	48	of	of	IN
cord-307860-iqk1yiw4	495	49	HIV-1	HIV-1	NNP
cord-307860-iqk1yiw4	495	50	replication	replication	NN
cord-307860-iqk1yiw4	495	51	SARS	SARS	NNP
cord-307860-iqk1yiw4	495	52	-	-	HYPH
cord-307860-iqk1yiw4	495	53	CoV	CoV	NNP
cord-307860-iqk1yiw4	495	54	and	and	CC
cord-307860-iqk1yiw4	495	55	SARS	SARS	NNP
cord-307860-iqk1yiw4	495	56	-	-	HYPH
cord-307860-iqk1yiw4	495	57	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	495	58	main	main	JJ
cord-307860-iqk1yiw4	495	59	protease	protease	NN
cord-307860-iqk1yiw4	495	60	residue	residue	NN
cord-307860-iqk1yiw4	495	61	interaction	interaction	NN
cord-307860-iqk1yiw4	495	62	networks	network	NNS
cord-307860-iqk1yiw4	495	63	change	change	NN
cord-307860-iqk1yiw4	495	64	when	when	WRB
cord-307860-iqk1yiw4	495	65	bound	bind	VBN
cord-307860-iqk1yiw4	495	66	to	to	IN
cord-307860-iqk1yiw4	495	67	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	495	68	N3	N3	NNP
cord-307860-iqk1yiw4	495	69	Design	Design	NNP
cord-307860-iqk1yiw4	495	70	of	of	IN
cord-307860-iqk1yiw4	495	71	wide	wide	JJ
cord-307860-iqk1yiw4	495	72	-	-	HYPH
cord-307860-iqk1yiw4	495	73	spectrum	spectrum	NN
cord-307860-iqk1yiw4	495	74	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	495	75	targeting	target	VBG
cord-307860-iqk1yiw4	495	76	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	495	77	main	main	JJ
cord-307860-iqk1yiw4	495	78	proteases	protease	NNS
cord-307860-iqk1yiw4	495	79	Structural	structural	JJ
cord-307860-iqk1yiw4	495	80	basis	basis	NN
cord-307860-iqk1yiw4	495	81	for	for	IN
cord-307860-iqk1yiw4	495	82	the	the	DT
cord-307860-iqk1yiw4	495	83	inhibition	inhibition	NN
cord-307860-iqk1yiw4	495	84	of	of	IN
cord-307860-iqk1yiw4	495	85	SARS	SARS	NNP
cord-307860-iqk1yiw4	495	86	-	-	HYPH
cord-307860-iqk1yiw4	495	87	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	495	88	main	main	JJ
cord-307860-iqk1yiw4	495	89	protease	protease	NN
cord-307860-iqk1yiw4	495	90	by	by	IN
cord-307860-iqk1yiw4	495	91	antineoplastic	antineoplastic	JJ
cord-307860-iqk1yiw4	495	92	drug	drug	NN
cord-307860-iqk1yiw4	495	93	carmofur	carmofur	NNP
cord-307860-iqk1yiw4	495	94	Structure	Structure	NNP
cord-307860-iqk1yiw4	495	95	of	of	IN
cord-307860-iqk1yiw4	495	96	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	496	1	main	main	JJ
cord-307860-iqk1yiw4	496	2	proteinase	proteinase	NN
cord-307860-iqk1yiw4	496	3	reveals	reveal	VBZ
cord-307860-iqk1yiw4	496	4	combination	combination	NN
cord-307860-iqk1yiw4	496	5	of	of	IN
cord-307860-iqk1yiw4	496	6	a	a	DT
cord-307860-iqk1yiw4	496	7	chymotrypsin	chymotrypsin	NN
cord-307860-iqk1yiw4	496	8	fold	fold	JJ
cord-307860-iqk1yiw4	496	9	with	with	IN
cord-307860-iqk1yiw4	496	10	an	an	DT
cord-307860-iqk1yiw4	496	11	extra	extra	JJ
cord-307860-iqk1yiw4	496	12	α	α	NN
cord-307860-iqk1yiw4	496	13	-	-	HYPH
cord-307860-iqk1yiw4	496	14	helical	helical	JJ
cord-307860-iqk1yiw4	496	15	domain	domain	NN
cord-307860-iqk1yiw4	496	16	Evidence	evidence	NN
cord-307860-iqk1yiw4	496	17	for	for	IN
cord-307860-iqk1yiw4	496	18	substrate	substrate	NN
cord-307860-iqk1yiw4	496	19	binding	binding	NN
cord-307860-iqk1yiw4	496	20	-	-	HYPH
cord-307860-iqk1yiw4	496	21	induced	induce	VBN
cord-307860-iqk1yiw4	496	22	zwitterion	zwitterion	NN
cord-307860-iqk1yiw4	496	23	formation	formation	NN
cord-307860-iqk1yiw4	496	24	in	in	IN
cord-307860-iqk1yiw4	496	25	the	the	DT
cord-307860-iqk1yiw4	496	26	catalytic	catalytic	JJ
cord-307860-iqk1yiw4	496	27	Cys	Cys	NNP
cord-307860-iqk1yiw4	496	28	-	-	HYPH
cord-307860-iqk1yiw4	496	29	His	-PRON-	PRP$
cord-307860-iqk1yiw4	496	30	dyad	dyad	NN
cord-307860-iqk1yiw4	496	31	of	of	IN
cord-307860-iqk1yiw4	496	32	the	the	DT
cord-307860-iqk1yiw4	496	33	SARS	SARS	NNP
cord-307860-iqk1yiw4	496	34	-	-	HYPH
cord-307860-iqk1yiw4	496	35	CoV	CoV	NNP
cord-307860-iqk1yiw4	496	36	main	main	JJ
cord-307860-iqk1yiw4	496	37	protease	protease	NN
cord-307860-iqk1yiw4	496	38	Comprehensive	comprehensive	JJ
cord-307860-iqk1yiw4	496	39	insights	insight	NNS
cord-307860-iqk1yiw4	496	40	into	into	IN
cord-307860-iqk1yiw4	496	41	the	the	DT
cord-307860-iqk1yiw4	496	42	catalytic	catalytic	JJ
cord-307860-iqk1yiw4	496	43	mechanism	mechanism	NN
cord-307860-iqk1yiw4	496	44	of	of	IN
cord-307860-iqk1yiw4	496	45	Middle	Middle	NNP
cord-307860-iqk1yiw4	496	46	East	East	NNP
cord-307860-iqk1yiw4	496	47	Respiratory	Respiratory	NNP
cord-307860-iqk1yiw4	496	48	Syndrome	Syndrome	NNP
cord-307860-iqk1yiw4	496	49	3C	3c	NN
cord-307860-iqk1yiw4	496	50	-	-	HYPH
cord-307860-iqk1yiw4	496	51	like	like	JJ
cord-307860-iqk1yiw4	496	52	protease	protease	NN
cord-307860-iqk1yiw4	496	53	and	and	CC
cord-307860-iqk1yiw4	496	54	severe	severe	JJ
cord-307860-iqk1yiw4	496	55	acute	acute	JJ
cord-307860-iqk1yiw4	496	56	respiratory	respiratory	JJ
cord-307860-iqk1yiw4	496	57	syndrome	syndrome	NN
cord-307860-iqk1yiw4	496	58	3C	3c	NN
cord-307860-iqk1yiw4	496	59	-	-	HYPH
cord-307860-iqk1yiw4	496	60	like	like	JJ
cord-307860-iqk1yiw4	496	61	protease	protease	NN
cord-307860-iqk1yiw4	496	62	Viral	Viral	NNP
cord-307860-iqk1yiw4	496	63	RNA	RNA	NNP
cord-307860-iqk1yiw4	496	64	polymerase	polymerase	NN
cord-307860-iqk1yiw4	496	65	:	:	:
cord-307860-iqk1yiw4	496	66	a	a	DT
cord-307860-iqk1yiw4	496	67	promising	promising	JJ
cord-307860-iqk1yiw4	496	68	antiviral	antiviral	JJ
cord-307860-iqk1yiw4	496	69	target	target	NN
cord-307860-iqk1yiw4	496	70	for	for	IN
cord-307860-iqk1yiw4	496	71	influenza	influenza	NN
cord-307860-iqk1yiw4	496	72	A	a	DT
cord-307860-iqk1yiw4	496	73	virus	virus	NN
cord-307860-iqk1yiw4	496	74	Feasibility	feasibility	NN
cord-307860-iqk1yiw4	496	75	of	of	IN
cord-307860-iqk1yiw4	496	76	known	know	VBN
cord-307860-iqk1yiw4	496	77	RNA	RNA	NNP
cord-307860-iqk1yiw4	496	78	polymerase	polymerase	NN
cord-307860-iqk1yiw4	496	79	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	496	80	as	as	IN
cord-307860-iqk1yiw4	496	81	anti	anti	JJ
cord-307860-iqk1yiw4	496	82	-	-	JJ
cord-307860-iqk1yiw4	496	83	SARS	SARS	NNP
cord-307860-iqk1yiw4	496	84	-	-	HYPH
cord-307860-iqk1yiw4	496	85	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	496	86	Drugs	drug	NNS
cord-307860-iqk1yiw4	496	87	.	.	.
cord-307860-iqk1yiw4	497	1	Pathogens	pathogen	NNS
cord-307860-iqk1yiw4	497	2	Nonstructural	Nonstructural	NNP
cord-307860-iqk1yiw4	497	3	proteins	protein	NNS
cord-307860-iqk1yiw4	497	4	7	7	CD
cord-307860-iqk1yiw4	497	5	and	and	CC
cord-307860-iqk1yiw4	497	6	8	8	CD
cord-307860-iqk1yiw4	497	7	of	of	IN
cord-307860-iqk1yiw4	497	8	feline	feline	JJ
cord-307860-iqk1yiw4	497	9	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	497	10	form	form	VB
cord-307860-iqk1yiw4	497	11	a	a	DT
cord-307860-iqk1yiw4	497	12	2:1	2:1	CD
cord-307860-iqk1yiw4	497	13	heterotrimer	heterotrimer	NN
cord-307860-iqk1yiw4	497	14	that	that	WDT
cord-307860-iqk1yiw4	497	15	exhibits	exhibit	VBZ
cord-307860-iqk1yiw4	497	16	primer	primer	NN
cord-307860-iqk1yiw4	497	17	-	-	HYPH
cord-307860-iqk1yiw4	497	18	independent	independent	JJ
cord-307860-iqk1yiw4	497	19	RNA	RNA	NNP
cord-307860-iqk1yiw4	497	20	polymerase	polymerase	NN
cord-307860-iqk1yiw4	497	21	activity	activity	NN
cord-307860-iqk1yiw4	498	1	The	the	DT
cord-307860-iqk1yiw4	498	2	SARS	SARS	NNP
cord-307860-iqk1yiw4	498	3	-	-	HYPH
cord-307860-iqk1yiw4	498	4	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	498	5	nsp7+nsp8	nsp7+nsp8	NNP
cord-307860-iqk1yiw4	498	6	complex	complex	NN
cord-307860-iqk1yiw4	498	7	is	be	VBZ
cord-307860-iqk1yiw4	498	8	a	a	DT
cord-307860-iqk1yiw4	498	9	unique	unique	JJ
cord-307860-iqk1yiw4	498	10	multimeric	multimeric	JJ
cord-307860-iqk1yiw4	498	11	RNA	RNA	NNP
cord-307860-iqk1yiw4	498	12	polymerase	polymerase	NN
cord-307860-iqk1yiw4	498	13	capable	capable	JJ
cord-307860-iqk1yiw4	498	14	of	of	IN
cord-307860-iqk1yiw4	498	15	both	both	DT
cord-307860-iqk1yiw4	498	16	de	de	FW
cord-307860-iqk1yiw4	498	17	novo	novo	NNP
cord-307860-iqk1yiw4	498	18	initiation	initiation	NN
cord-307860-iqk1yiw4	498	19	and	and	CC
cord-307860-iqk1yiw4	498	20	primer	primer	NN
cord-307860-iqk1yiw4	498	21	extension	extension	NN
cord-307860-iqk1yiw4	498	22	Structure	Structure	NNP
cord-307860-iqk1yiw4	498	23	of	of	IN
cord-307860-iqk1yiw4	498	24	the	the	DT
cord-307860-iqk1yiw4	498	25	SARS	SARS	NNP
cord-307860-iqk1yiw4	498	26	-	-	HYPH
cord-307860-iqk1yiw4	498	27	CoV	CoV	NNP
cord-307860-iqk1yiw4	498	28	nsp12	nsp12	CD
cord-307860-iqk1yiw4	498	29	polymerase	polymerase	NN
cord-307860-iqk1yiw4	498	30	bound	bind	VBN
cord-307860-iqk1yiw4	498	31	to	to	IN
cord-307860-iqk1yiw4	498	32	nsp7	nsp7	NN
cord-307860-iqk1yiw4	498	33	and	and	CC
cord-307860-iqk1yiw4	498	34	nsp8	nsp8	NN
cord-307860-iqk1yiw4	498	35	co	co	NNS
cord-307860-iqk1yiw4	498	36	-	-	NNS
cord-307860-iqk1yiw4	498	37	factors	factor	NNS
cord-307860-iqk1yiw4	498	38	Therapeutic	therapeutic	JJ
cord-307860-iqk1yiw4	498	39	efficacy	efficacy	NN
cord-307860-iqk1yiw4	498	40	of	of	IN
cord-307860-iqk1yiw4	498	41	the	the	DT
cord-307860-iqk1yiw4	498	42	small	small	JJ
cord-307860-iqk1yiw4	498	43	molecule	molecule	NN
cord-307860-iqk1yiw4	498	44	GS-5734	GS-5734	NNS
cord-307860-iqk1yiw4	498	45	against	against	IN
cord-307860-iqk1yiw4	498	46	Ebola	Ebola	NNP
cord-307860-iqk1yiw4	498	47	virus	virus	NN
cord-307860-iqk1yiw4	498	48	in	in	IN
cord-307860-iqk1yiw4	498	49	rhesus	rhesu	NNS
cord-307860-iqk1yiw4	498	50	monkeys	monkey	NNS
cord-307860-iqk1yiw4	498	51	Broad	Broad	NNP
cord-307860-iqk1yiw4	498	52	-	-	HYPH
cord-307860-iqk1yiw4	498	53	spectrum	spectrum	NN
cord-307860-iqk1yiw4	498	54	antiviral	antiviral	JJ
cord-307860-iqk1yiw4	498	55	GS-5734	GS-5734	NNS
cord-307860-iqk1yiw4	499	1	inhibits	inhibit	NNS
cord-307860-iqk1yiw4	499	2	both	both	DT
cord-307860-iqk1yiw4	499	3	epidemic	epidemic	NN
cord-307860-iqk1yiw4	499	4	and	and	CC
cord-307860-iqk1yiw4	499	5	zoonotic	zoonotic	JJ
cord-307860-iqk1yiw4	499	6	coronaviruses	coronaviruse	NNS
cord-307860-iqk1yiw4	500	1	Remdesivir	Remdesivir	NNP
cord-307860-iqk1yiw4	500	2	is	be	VBZ
cord-307860-iqk1yiw4	500	3	a	a	DT
cord-307860-iqk1yiw4	500	4	direct	direct	JJ
cord-307860-iqk1yiw4	500	5	-	-	HYPH
cord-307860-iqk1yiw4	500	6	acting	act	VBG
cord-307860-iqk1yiw4	500	7	antiviral	antiviral	JJ
cord-307860-iqk1yiw4	500	8	that	that	WDT
cord-307860-iqk1yiw4	500	9	inhibits	inhibit	VBZ
cord-307860-iqk1yiw4	500	10	RNA	rna	NN
cord-307860-iqk1yiw4	500	11	-	-	HYPH
cord-307860-iqk1yiw4	500	12	dependent	dependent	JJ
cord-307860-iqk1yiw4	500	13	RNA	RNA	NNP
cord-307860-iqk1yiw4	500	14	polymerase	polymerase	NN
cord-307860-iqk1yiw4	500	15	from	from	IN
cord-307860-iqk1yiw4	500	16	severe	severe	JJ
cord-307860-iqk1yiw4	500	17	acute	acute	JJ
cord-307860-iqk1yiw4	500	18	respiratory	respiratory	JJ
cord-307860-iqk1yiw4	500	19	syndrome	syndrome	NN
cord-307860-iqk1yiw4	500	20	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	500	21	2	2	CD
cord-307860-iqk1yiw4	500	22	with	with	IN
cord-307860-iqk1yiw4	500	23	high	high	JJ
cord-307860-iqk1yiw4	500	24	potency	potency	NN
cord-307860-iqk1yiw4	500	25	Coronavirus	Coronavirus	NNP
cord-307860-iqk1yiw4	500	26	susceptibility	susceptibility	NN
cord-307860-iqk1yiw4	500	27	to	to	IN
cord-307860-iqk1yiw4	500	28	the	the	DT
cord-307860-iqk1yiw4	500	29	antiviral	antiviral	JJ
cord-307860-iqk1yiw4	500	30	remdesivir	remdesivir	NNS
cord-307860-iqk1yiw4	500	31	(	(	-LRB-
cord-307860-iqk1yiw4	500	32	GS-5734	GS-5734	NNP
cord-307860-iqk1yiw4	500	33	)	)	-RRB-
cord-307860-iqk1yiw4	500	34	is	be	VBZ
cord-307860-iqk1yiw4	500	35	mediated	mediate	VBN
cord-307860-iqk1yiw4	500	36	by	by	IN
cord-307860-iqk1yiw4	500	37	the	the	DT
cord-307860-iqk1yiw4	500	38	viral	viral	JJ
cord-307860-iqk1yiw4	500	39	polymerase	polymerase	NN
cord-307860-iqk1yiw4	500	40	and	and	CC
cord-307860-iqk1yiw4	500	41	the	the	DT
cord-307860-iqk1yiw4	500	42	proofreading	proofreading	NN
cord-307860-iqk1yiw4	500	43	exoribonuclease	exoribonuclease	NN
cord-307860-iqk1yiw4	501	1	The	the	DT
cord-307860-iqk1yiw4	501	2	antiviral	antiviral	JJ
cord-307860-iqk1yiw4	501	3	compound	compound	NN
cord-307860-iqk1yiw4	501	4	remdesivir	remdesivir	NNS
cord-307860-iqk1yiw4	501	5	potently	potently	RB
cord-307860-iqk1yiw4	501	6	inhibits	inhibit	VBZ
cord-307860-iqk1yiw4	501	7	RNAdependent	RNAdependent	NNP
cord-307860-iqk1yiw4	501	8	RNA	RNA	NNP
cord-307860-iqk1yiw4	501	9	polymerase	polymerase	NN
cord-307860-iqk1yiw4	501	10	from	from	IN
cord-307860-iqk1yiw4	501	11	Middle	Middle	NNP
cord-307860-iqk1yiw4	501	12	East	East	NNP
cord-307860-iqk1yiw4	501	13	respiratory	respiratory	JJ
cord-307860-iqk1yiw4	501	14	syndrome	syndrome	NN
cord-307860-iqk1yiw4	501	15	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	501	16	Remdesivir	Remdesivir	NNP
cord-307860-iqk1yiw4	501	17	for	for	IN
cord-307860-iqk1yiw4	501	18	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	501	19	:	:	:
cord-307860-iqk1yiw4	501	20	challenges	challenge	NNS
cord-307860-iqk1yiw4	501	21	of	of	IN
cord-307860-iqk1yiw4	501	22	underpowered	underpowered	JJ
cord-307860-iqk1yiw4	501	23	studies	study	NNS
cord-307860-iqk1yiw4	502	1	RNA	RNA	NNP
cord-307860-iqk1yiw4	502	2	3′-end	3′-end	CD
cord-307860-iqk1yiw4	502	3	mismatch	mismatch	NN
cord-307860-iqk1yiw4	502	4	excision	excision	NN
cord-307860-iqk1yiw4	502	5	by	by	IN
cord-307860-iqk1yiw4	502	6	the	the	DT
cord-307860-iqk1yiw4	502	7	severe	severe	JJ
cord-307860-iqk1yiw4	502	8	acute	acute	JJ
cord-307860-iqk1yiw4	502	9	respiratory	respiratory	JJ
cord-307860-iqk1yiw4	502	10	syndrome	syndrome	NN
cord-307860-iqk1yiw4	502	11	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	502	12	nonstructural	nonstructural	JJ
cord-307860-iqk1yiw4	502	13	protein	protein	NN
cord-307860-iqk1yiw4	503	1	nsp10	nsp10	NNP
cord-307860-iqk1yiw4	503	2	/	/	SYM
cord-307860-iqk1yiw4	503	3	nsp14	nsp14	XX
cord-307860-iqk1yiw4	504	1	exoribonuclease	exoribonuclease	NNP
cord-307860-iqk1yiw4	504	2	complex	complex	NNP
cord-307860-iqk1yiw4	504	3	Mechanism	Mechanism	NNP
cord-307860-iqk1yiw4	504	4	of	of	IN
cord-307860-iqk1yiw4	504	5	inhibition	inhibition	NN
cord-307860-iqk1yiw4	504	6	of	of	IN
cord-307860-iqk1yiw4	504	7	ebola	ebola	NNP
cord-307860-iqk1yiw4	504	8	virus	virus	NN
cord-307860-iqk1yiw4	504	9	RNA	RNA	NNP
cord-307860-iqk1yiw4	504	10	-	-	HYPH
cord-307860-iqk1yiw4	504	11	dependent	dependent	JJ
cord-307860-iqk1yiw4	504	12	RNA	RNA	NNP
cord-307860-iqk1yiw4	504	13	polymerase	polymerase	NN
cord-307860-iqk1yiw4	504	14	by	by	IN
cord-307860-iqk1yiw4	504	15	remdesivir	remdesivir	NNP
cord-307860-iqk1yiw4	504	16	Bat	Bat	NNP
cord-307860-iqk1yiw4	504	17	flight	flight	NN
cord-307860-iqk1yiw4	504	18	and	and	CC
cord-307860-iqk1yiw4	504	19	zoonotic	zoonotic	JJ
cord-307860-iqk1yiw4	504	20	viruses	virus	NNS
cord-307860-iqk1yiw4	504	21	Analysis	Analysis	NNP
cord-307860-iqk1yiw4	504	22	of	of	IN
cord-307860-iqk1yiw4	504	23	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	504	24	temperature	temperature	NN
cord-307860-iqk1yiw4	504	25	-	-	HYPH
cord-307860-iqk1yiw4	504	26	sensitive	sensitive	JJ
cord-307860-iqk1yiw4	504	27	mutants	mutant	NNS
cord-307860-iqk1yiw4	504	28	reveals	reveal	VBZ
cord-307860-iqk1yiw4	504	29	an	an	DT
cord-307860-iqk1yiw4	504	30	interplay	interplay	NN
cord-307860-iqk1yiw4	504	31	between	between	IN
cord-307860-iqk1yiw4	504	32	the	the	DT
cord-307860-iqk1yiw4	504	33	macrodomain	macrodomain	NN
cord-307860-iqk1yiw4	504	34	and	and	CC
cord-307860-iqk1yiw4	504	35	papain	papain	NN
cord-307860-iqk1yiw4	504	36	-	-	HYPH
cord-307860-iqk1yiw4	504	37	like	like	JJ
cord-307860-iqk1yiw4	504	38	protease	protease	NN
cord-307860-iqk1yiw4	504	39	impacting	impact	VBG
cord-307860-iqk1yiw4	504	40	replication	replication	NN
cord-307860-iqk1yiw4	504	41	and	and	CC
cord-307860-iqk1yiw4	504	42	pathogenesis	pathogenesis	NN
cord-307860-iqk1yiw4	505	1	Severe	severe	JJ
cord-307860-iqk1yiw4	505	2	acute	acute	JJ
cord-307860-iqk1yiw4	505	3	respiratory	respiratory	JJ
cord-307860-iqk1yiw4	505	4	syndrome	syndrome	NN
cord-307860-iqk1yiw4	505	5	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	505	6	papain	papain	NN
cord-307860-iqk1yiw4	505	7	-	-	HYPH
cord-307860-iqk1yiw4	505	8	like	like	JJ
cord-307860-iqk1yiw4	505	9	novel	novel	JJ
cord-307860-iqk1yiw4	505	10	protease	protease	NN
cord-307860-iqk1yiw4	505	11	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	505	12	:	:	:
cord-307860-iqk1yiw4	505	13	design	design	NN
cord-307860-iqk1yiw4	505	14	,	,	,
cord-307860-iqk1yiw4	505	15	synthesis	synthesis	NN
cord-307860-iqk1yiw4	505	16	,	,	,
cord-307860-iqk1yiw4	505	17	protein	protein	NN
cord-307860-iqk1yiw4	505	18	-	-	HYPH
cord-307860-iqk1yiw4	505	19	ligand	ligand	NN
cord-307860-iqk1yiw4	505	20	X	x	NN
cord-307860-iqk1yiw4	505	21	-	-	NN
cord-307860-iqk1yiw4	505	22	ray	ray	NN
cord-307860-iqk1yiw4	505	23	structure	structure	NN
cord-307860-iqk1yiw4	505	24	and	and	CC
cord-307860-iqk1yiw4	505	25	biological	biological	JJ
cord-307860-iqk1yiw4	505	26	evaluation	evaluation	NN
cord-307860-iqk1yiw4	505	27	A	a	DT
cord-307860-iqk1yiw4	505	28	noncovalent	noncovalent	JJ
cord-307860-iqk1yiw4	505	29	class	class	NN
cord-307860-iqk1yiw4	505	30	of	of	IN
cord-307860-iqk1yiw4	506	1	papain	papain	NN
cord-307860-iqk1yiw4	506	2	-	-	HYPH
cord-307860-iqk1yiw4	506	3	like	like	JJ
cord-307860-iqk1yiw4	506	4	protease/	protease/	ADD
cord-307860-iqk1yiw4	507	1	deubiquitinase	deubiquitinase	NNP
cord-307860-iqk1yiw4	507	2	inhibitors	inhibitors	NNP
cord-307860-iqk1yiw4	507	3	blocks	block	VBZ
cord-307860-iqk1yiw4	507	4	SARS	SARS	NNP
cord-307860-iqk1yiw4	507	5	virus	virus	NN
cord-307860-iqk1yiw4	507	6	replication	replication	NN
cord-307860-iqk1yiw4	507	7	Biochemical	biochemical	JJ
cord-307860-iqk1yiw4	507	8	and	and	CC
cord-307860-iqk1yiw4	507	9	immunological	immunological	JJ
cord-307860-iqk1yiw4	507	10	studies	study	NNS
cord-307860-iqk1yiw4	507	11	of	of	IN
cord-307860-iqk1yiw4	507	12	nucleocapsid	nucleocapsid	NN
cord-307860-iqk1yiw4	507	13	proteins	protein	NNS
cord-307860-iqk1yiw4	507	14	of	of	IN
cord-307860-iqk1yiw4	507	15	severe	severe	JJ
cord-307860-iqk1yiw4	507	16	acute	acute	JJ
cord-307860-iqk1yiw4	507	17	respiratory	respiratory	JJ
cord-307860-iqk1yiw4	507	18	syndrome	syndrome	NN
cord-307860-iqk1yiw4	507	19	and	and	CC
cord-307860-iqk1yiw4	507	20	229E	229e	CD
cord-307860-iqk1yiw4	507	21	human	human	JJ
cord-307860-iqk1yiw4	507	22	coronaviruses	coronaviruse	NNS
cord-307860-iqk1yiw4	508	1	Structural	structural	JJ
cord-307860-iqk1yiw4	508	2	basis	basis	NN
cord-307860-iqk1yiw4	508	3	for	for	IN
cord-307860-iqk1yiw4	508	4	the	the	DT
cord-307860-iqk1yiw4	508	5	identification	identification	NN
cord-307860-iqk1yiw4	508	6	of	of	IN
cord-307860-iqk1yiw4	508	7	the	the	DT
cord-307860-iqk1yiw4	508	8	N	n	CD
cord-307860-iqk1yiw4	508	9	-	-	HYPH
cord-307860-iqk1yiw4	508	10	terminal	terminal	NN
cord-307860-iqk1yiw4	508	11	domain	domain	NN
cord-307860-iqk1yiw4	508	12	of	of	IN
cord-307860-iqk1yiw4	508	13	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	508	14	nucleocapsid	nucleocapsid	NN
cord-307860-iqk1yiw4	508	15	protein	protein	NN
cord-307860-iqk1yiw4	508	16	as	as	IN
cord-307860-iqk1yiw4	508	17	an	an	DT
cord-307860-iqk1yiw4	508	18	antiviral	antiviral	JJ
cord-307860-iqk1yiw4	508	19	target	target	NN
cord-307860-iqk1yiw4	508	20	A	a	DT
cord-307860-iqk1yiw4	508	21	pan	pan	JJ
cord-307860-iqk1yiw4	508	22	-	-	JJ
cord-307860-iqk1yiw4	508	23	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	508	24	fusion	fusion	NN
cord-307860-iqk1yiw4	508	25	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	508	26	targeting	target	VBG
cord-307860-iqk1yiw4	508	27	the	the	DT
cord-307860-iqk1yiw4	508	28	HR1	HR1	NNP
cord-307860-iqk1yiw4	508	29	domain	domain	NN
cord-307860-iqk1yiw4	508	30	of	of	IN
cord-307860-iqk1yiw4	508	31	human	human	JJ
cord-307860-iqk1yiw4	508	32	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	508	33	spike	spike	NN
cord-307860-iqk1yiw4	508	34	Structure	Structure	NNP
cord-307860-iqk1yiw4	508	35	,	,	,
cord-307860-iqk1yiw4	508	36	function	function	NN
cord-307860-iqk1yiw4	508	37	,	,	,
cord-307860-iqk1yiw4	508	38	and	and	CC
cord-307860-iqk1yiw4	508	39	evolution	evolution	NN
cord-307860-iqk1yiw4	508	40	of	of	IN
cord-307860-iqk1yiw4	508	41	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	508	42	spike	spike	NN
cord-307860-iqk1yiw4	508	43	proteins	protein	NNS
cord-307860-iqk1yiw4	508	44	Entry	Entry	NNP
cord-307860-iqk1yiw4	508	45	of	of	IN
cord-307860-iqk1yiw4	508	46	human	human	JJ
cord-307860-iqk1yiw4	508	47	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	509	1	NL63	nl63	RB
cord-307860-iqk1yiw4	509	2	into	into	IN
cord-307860-iqk1yiw4	509	3	the	the	DT
cord-307860-iqk1yiw4	509	4	cell	cell	NN
cord-307860-iqk1yiw4	509	5	Molecular	molecular	JJ
cord-307860-iqk1yiw4	509	6	basis	basis	NN
cord-307860-iqk1yiw4	509	7	of	of	IN
cord-307860-iqk1yiw4	509	8	binding	bind	VBG
cord-307860-iqk1yiw4	509	9	between	between	IN
cord-307860-iqk1yiw4	509	10	novel	novel	JJ
cord-307860-iqk1yiw4	509	11	human	human	JJ
cord-307860-iqk1yiw4	509	12	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	509	13	MERS	MERS	NNP
cord-307860-iqk1yiw4	509	14	-	-	HYPH
cord-307860-iqk1yiw4	509	15	CoV	CoV	NNP
cord-307860-iqk1yiw4	509	16	and	and	CC
cord-307860-iqk1yiw4	509	17	its	-PRON-	PRP$
cord-307860-iqk1yiw4	509	18	receptor	receptor	NN
cord-307860-iqk1yiw4	509	19	CD26	CD26	NNP
cord-307860-iqk1yiw4	509	20	Dipeptidyl	Dipeptidyl	NNP
cord-307860-iqk1yiw4	509	21	peptidase	peptidase	NN
cord-307860-iqk1yiw4	509	22	4	4	CD
cord-307860-iqk1yiw4	509	23	is	be	VBZ
cord-307860-iqk1yiw4	509	24	a	a	DT
cord-307860-iqk1yiw4	509	25	functional	functional	JJ
cord-307860-iqk1yiw4	509	26	receptor	receptor	NN
cord-307860-iqk1yiw4	509	27	for	for	IN
cord-307860-iqk1yiw4	509	28	the	the	DT
cord-307860-iqk1yiw4	509	29	emerging	emerge	VBG
cord-307860-iqk1yiw4	509	30	human	human	JJ
cord-307860-iqk1yiw4	509	31	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	509	32	-	-	HYPH
cord-307860-iqk1yiw4	509	33	EMC	EMC	NNP
cord-307860-iqk1yiw4	509	34	Reverse	Reverse	NNP
cord-307860-iqk1yiw4	509	35	genetics	genetic	NNS
cord-307860-iqk1yiw4	509	36	with	with	IN
cord-307860-iqk1yiw4	509	37	a	a	DT
cord-307860-iqk1yiw4	509	38	full	full	JJ
cord-307860-iqk1yiw4	509	39	-	-	HYPH
cord-307860-iqk1yiw4	509	40	length	length	NN
cord-307860-iqk1yiw4	509	41	infectious	infectious	JJ
cord-307860-iqk1yiw4	509	42	cDNA	cdna	NN
cord-307860-iqk1yiw4	509	43	of	of	IN
cord-307860-iqk1yiw4	509	44	the	the	DT
cord-307860-iqk1yiw4	509	45	Middle	Middle	NNP
cord-307860-iqk1yiw4	509	46	East	East	NNP
cord-307860-iqk1yiw4	509	47	respiratory	respiratory	JJ
cord-307860-iqk1yiw4	509	48	syndrome	syndrome	NN
cord-307860-iqk1yiw4	509	49	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	509	50	Host	host	NN
cord-307860-iqk1yiw4	509	51	cell	cell	NN
cord-307860-iqk1yiw4	509	52	proteases	protease	NNS
cord-307860-iqk1yiw4	509	53	:	:	:
cord-307860-iqk1yiw4	509	54	critical	critical	JJ
cord-307860-iqk1yiw4	509	55	determinants	determinant	NNS
cord-307860-iqk1yiw4	509	56	of	of	IN
cord-307860-iqk1yiw4	509	57	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	509	58	tropism	tropism	NN
cord-307860-iqk1yiw4	509	59	and	and	CC
cord-307860-iqk1yiw4	509	60	pathogenesis	pathogenesis	NN
cord-307860-iqk1yiw4	509	61	SARS	SARS	NNP
cord-307860-iqk1yiw4	509	62	-	-	HYPH
cord-307860-iqk1yiw4	509	63	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	509	64	cell	cell	NN
cord-307860-iqk1yiw4	509	65	entry	entry	NN
cord-307860-iqk1yiw4	509	66	depends	depend	VBZ
cord-307860-iqk1yiw4	509	67	on	on	IN
cord-307860-iqk1yiw4	509	68	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	509	69	and	and	CC
cord-307860-iqk1yiw4	509	70	TMPRSS2	TMPRSS2	NNP
cord-307860-iqk1yiw4	509	71	and	and	CC
cord-307860-iqk1yiw4	509	72	is	be	VBZ
cord-307860-iqk1yiw4	509	73	blocked	block	VBN
cord-307860-iqk1yiw4	509	74	by	by	IN
cord-307860-iqk1yiw4	509	75	a	a	DT
cord-307860-iqk1yiw4	509	76	clinically	clinically	RB
cord-307860-iqk1yiw4	509	77	proven	prove	VBN
cord-307860-iqk1yiw4	509	78	protease	protease	NN
cord-307860-iqk1yiw4	509	79	inhibitor	inhibitor	NN
cord-307860-iqk1yiw4	509	80	Cell	cell	NN
cord-307860-iqk1yiw4	509	81	entry	entry	NN
cord-307860-iqk1yiw4	509	82	mechanisms	mechanism	NNS
cord-307860-iqk1yiw4	509	83	of	of	IN
cord-307860-iqk1yiw4	509	84	SARS	SARS	NNP
cord-307860-iqk1yiw4	509	85	-	-	HYPH
cord-307860-iqk1yiw4	509	86	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	510	1	TMPRSS2	TMPRSS2	NNP
cord-307860-iqk1yiw4	510	2	:	:	:
cord-307860-iqk1yiw4	510	3	a	a	DT
cord-307860-iqk1yiw4	510	4	potential	potential	JJ
cord-307860-iqk1yiw4	510	5	target	target	NN
cord-307860-iqk1yiw4	510	6	for	for	IN
cord-307860-iqk1yiw4	510	7	treatment	treatment	NN
cord-307860-iqk1yiw4	510	8	of	of	IN
cord-307860-iqk1yiw4	510	9	influenza	influenza	NN
cord-307860-iqk1yiw4	510	10	virus	virus	NN
cord-307860-iqk1yiw4	510	11	and	and	CC
cord-307860-iqk1yiw4	510	12	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	510	13	infections	infection	NNS
cord-307860-iqk1yiw4	510	14	X	x	NN
cord-307860-iqk1yiw4	510	15	-	-	NN
cord-307860-iqk1yiw4	510	16	ray	ray	JJ
cord-307860-iqk1yiw4	510	17	structures	structure	NNS
cord-307860-iqk1yiw4	510	18	of	of	IN
cord-307860-iqk1yiw4	510	19	human	human	JJ
cord-307860-iqk1yiw4	510	20	furin	furin	NN
cord-307860-iqk1yiw4	510	21	in	in	IN
cord-307860-iqk1yiw4	510	22	complex	complex	NN
cord-307860-iqk1yiw4	510	23	with	with	IN
cord-307860-iqk1yiw4	510	24	competitive	competitive	JJ
cord-307860-iqk1yiw4	510	25	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	511	1	Novel	novel	NN
cord-307860-iqk1yiw4	511	2	furin	furin	NN
cord-307860-iqk1yiw4	511	3	inhibitors	inhibitor	NNS
cord-307860-iqk1yiw4	511	4	with	with	IN
cord-307860-iqk1yiw4	511	5	potent	potent	JJ
cord-307860-iqk1yiw4	511	6	anti	anti	JJ
cord-307860-iqk1yiw4	511	7	-	-	JJ
cord-307860-iqk1yiw4	511	8	infectious	infectious	JJ
cord-307860-iqk1yiw4	511	9	activity	activity	NN
cord-307860-iqk1yiw4	512	1	The	the	DT
cord-307860-iqk1yiw4	512	2	biology	biology	NN
cord-307860-iqk1yiw4	512	3	and	and	CC
cord-307860-iqk1yiw4	512	4	therapeutic	therapeutic	JJ
cord-307860-iqk1yiw4	512	5	targeting	targeting	NN
cord-307860-iqk1yiw4	512	6	of	of	IN
cord-307860-iqk1yiw4	512	7	the	the	DT
cord-307860-iqk1yiw4	512	8	proprotein	proprotein	NNP
cord-307860-iqk1yiw4	512	9	convertases	convertases	NNP
cord-307860-iqk1yiw4	512	10	Potential	potential	JJ
cord-307860-iqk1yiw4	512	11	therapeutic	therapeutic	JJ
cord-307860-iqk1yiw4	512	12	targeting	targeting	NN
cord-307860-iqk1yiw4	512	13	of	of	IN
cord-307860-iqk1yiw4	512	14	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	512	15	spike	spike	NN
cord-307860-iqk1yiw4	512	16	glycoprotein	glycoprotein	NN
cord-307860-iqk1yiw4	512	17	priming	prime	VBG
cord-307860-iqk1yiw4	512	18	Structural	structural	JJ
cord-307860-iqk1yiw4	512	19	basis	basis	NN
cord-307860-iqk1yiw4	512	20	of	of	IN
cord-307860-iqk1yiw4	512	21	receptor	receptor	NN
cord-307860-iqk1yiw4	512	22	recognition	recognition	NN
cord-307860-iqk1yiw4	512	23	by	by	IN
cord-307860-iqk1yiw4	512	24	SARS	SARS	NNP
cord-307860-iqk1yiw4	512	25	-	-	HYPH
cord-307860-iqk1yiw4	512	26	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	512	27	Structure	Structure	NNP
cord-307860-iqk1yiw4	512	28	of	of	IN
cord-307860-iqk1yiw4	512	29	SARS	SARS	NNP
cord-307860-iqk1yiw4	512	30	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	512	31	spike	spike	NN
cord-307860-iqk1yiw4	512	32	receptor	receptor	NN
cord-307860-iqk1yiw4	512	33	-	-	HYPH
cord-307860-iqk1yiw4	512	34	binding	bind	VBG
cord-307860-iqk1yiw4	512	35	domain	domain	NN
cord-307860-iqk1yiw4	512	36	complexed	complexe	VBN
cord-307860-iqk1yiw4	512	37	with	with	IN
cord-307860-iqk1yiw4	512	38	receptor	receptor	NN
cord-307860-iqk1yiw4	513	1	A	a	DT
cord-307860-iqk1yiw4	513	2	193-amino	193-amino	CD
cord-307860-iqk1yiw4	513	3	acid	acid	NN
cord-307860-iqk1yiw4	513	4	fragment	fragment	NN
cord-307860-iqk1yiw4	513	5	of	of	IN
cord-307860-iqk1yiw4	513	6	the	the	DT
cord-307860-iqk1yiw4	513	7	SARS	SARS	NNP
cord-307860-iqk1yiw4	513	8	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	513	9	S	S	NNP
cord-307860-iqk1yiw4	513	10	protein	protein	NN
cord-307860-iqk1yiw4	513	11	efficiently	efficiently	RB
cord-307860-iqk1yiw4	513	12	binds	bind	VBZ
cord-307860-iqk1yiw4	513	13	angiotensin	angiotensin	NN
cord-307860-iqk1yiw4	513	14	-	-	HYPH
cord-307860-iqk1yiw4	513	15	converting	convert	VBG
cord-307860-iqk1yiw4	513	16	enzyme	enzyme	NN
cord-307860-iqk1yiw4	513	17	2	2	CD
cord-307860-iqk1yiw4	513	18	CD209L	cd209l	NN
cord-307860-iqk1yiw4	513	19	(	(	-LRB-
cord-307860-iqk1yiw4	513	20	L	l	NN
cord-307860-iqk1yiw4	513	21	-	-	HYPH
cord-307860-iqk1yiw4	513	22	SIGN	SIGN	NNP
cord-307860-iqk1yiw4	513	23	)	)	-RRB-
cord-307860-iqk1yiw4	513	24	is	be	VBZ
cord-307860-iqk1yiw4	513	25	a	a	DT
cord-307860-iqk1yiw4	513	26	receptor	receptor	NN
cord-307860-iqk1yiw4	513	27	for	for	IN
cord-307860-iqk1yiw4	513	28	severe	severe	JJ
cord-307860-iqk1yiw4	513	29	acute	acute	JJ
cord-307860-iqk1yiw4	513	30	respiratory	respiratory	JJ
cord-307860-iqk1yiw4	513	31	syndrome	syndrome	NN
cord-307860-iqk1yiw4	513	32	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	513	33	Activation	Activation	NNP
cord-307860-iqk1yiw4	513	34	of	of	IN
cord-307860-iqk1yiw4	513	35	the	the	DT
cord-307860-iqk1yiw4	513	36	SARS	SARS	NNP
cord-307860-iqk1yiw4	513	37	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	513	38	spike	spike	NN
cord-307860-iqk1yiw4	513	39	protein	protein	NN
cord-307860-iqk1yiw4	513	40	via	via	IN
cord-307860-iqk1yiw4	513	41	sequential	sequential	JJ
cord-307860-iqk1yiw4	513	42	proteolytic	proteolytic	JJ
cord-307860-iqk1yiw4	513	43	cleavage	cleavage	NN
cord-307860-iqk1yiw4	513	44	at	at	IN
cord-307860-iqk1yiw4	513	45	two	two	CD
cord-307860-iqk1yiw4	513	46	distinct	distinct	JJ
cord-307860-iqk1yiw4	513	47	sites	site	NNS
cord-307860-iqk1yiw4	513	48	Computational	computational	JJ
cord-307860-iqk1yiw4	513	49	prediction	prediction	NN
cord-307860-iqk1yiw4	513	50	of	of	IN
cord-307860-iqk1yiw4	513	51	furin	furin	NN
cord-307860-iqk1yiw4	513	52	cleavage	cleavage	NN
cord-307860-iqk1yiw4	513	53	sites	site	NNS
cord-307860-iqk1yiw4	513	54	by	by	IN
cord-307860-iqk1yiw4	513	55	a	a	DT
cord-307860-iqk1yiw4	513	56	hybrid	hybrid	JJ
cord-307860-iqk1yiw4	513	57	method	method	NN
cord-307860-iqk1yiw4	513	58	and	and	CC
cord-307860-iqk1yiw4	513	59	understanding	understanding	NN
cord-307860-iqk1yiw4	513	60	mechanism	mechanism	NN
cord-307860-iqk1yiw4	513	61	underlying	underlie	VBG
cord-307860-iqk1yiw4	513	62	diseases	disease	NNS
cord-307860-iqk1yiw4	514	1	The	the	DT
cord-307860-iqk1yiw4	514	2	D614	d614	NN
cord-307860-iqk1yiw4	514	3	G	g	NN
cord-307860-iqk1yiw4	514	4	mutation	mutation	NN
cord-307860-iqk1yiw4	514	5	in	in	IN
cord-307860-iqk1yiw4	514	6	the	the	DT
cord-307860-iqk1yiw4	514	7	SARS	SARS	NNP
cord-307860-iqk1yiw4	514	8	-	-	HYPH
cord-307860-iqk1yiw4	514	9	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	514	10	spike	spike	NN
cord-307860-iqk1yiw4	514	11	protein	protein	NN
cord-307860-iqk1yiw4	514	12	reduces	reduce	VBZ
cord-307860-iqk1yiw4	514	13	S1	s1	NN
cord-307860-iqk1yiw4	514	14	shedding	shedding	NN
cord-307860-iqk1yiw4	514	15	and	and	CC
cord-307860-iqk1yiw4	514	16	increases	increase	VBZ
cord-307860-iqk1yiw4	514	17	infectivity	infectivity	NN
cord-307860-iqk1yiw4	514	18	Evidence	evidence	NN
cord-307860-iqk1yiw4	514	19	for	for	IN
cord-307860-iqk1yiw4	514	20	mutations	mutation	NNS
cord-307860-iqk1yiw4	514	21	in	in	IN
cord-307860-iqk1yiw4	514	22	SARS	SARS	NNP
cord-307860-iqk1yiw4	514	23	-	-	HYPH
cord-307860-iqk1yiw4	514	24	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	515	1	Italian	italian	JJ
cord-307860-iqk1yiw4	515	2	isolates	isolate	VBZ
cord-307860-iqk1yiw4	515	3	potentially	potentially	RB
cord-307860-iqk1yiw4	515	4	affecting	affect	VBG
cord-307860-iqk1yiw4	515	5	virus	virus	NN
cord-307860-iqk1yiw4	515	6	transmission	transmission	NN
cord-307860-iqk1yiw4	516	1	The	the	DT
cord-307860-iqk1yiw4	516	2	Spike	spike	NN
cord-307860-iqk1yiw4	516	3	D614	d614	NN
cord-307860-iqk1yiw4	516	4	G	g	NN
cord-307860-iqk1yiw4	516	5	mutation	mutation	NN
cord-307860-iqk1yiw4	516	6	increases	increase	VBZ
cord-307860-iqk1yiw4	516	7	SARS	SARS	NNP
cord-307860-iqk1yiw4	516	8	-	-	HYPH
cord-307860-iqk1yiw4	516	9	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	516	10	infection	infection	NN
cord-307860-iqk1yiw4	516	11	of	of	IN
cord-307860-iqk1yiw4	516	12	multiple	multiple	JJ
cord-307860-iqk1yiw4	516	13	human	human	JJ
cord-307860-iqk1yiw4	516	14	cell	cell	NN
cord-307860-iqk1yiw4	516	15	types	type	NNS
cord-307860-iqk1yiw4	516	16	Interaction	Interaction	NNP
cord-307860-iqk1yiw4	516	17	of	of	IN
cord-307860-iqk1yiw4	516	18	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	516	19	and	and	CC
cord-307860-iqk1yiw4	516	20	integrin	integrin	VBD
cord-307860-iqk1yiw4	516	21	beta1	beta1	NN
cord-307860-iqk1yiw4	516	22	in	in	IN
cord-307860-iqk1yiw4	516	23	failing	fail	VBG
cord-307860-iqk1yiw4	516	24	human	human	JJ
cord-307860-iqk1yiw4	516	25	heart	heart	NN
cord-307860-iqk1yiw4	516	26	Focus	Focus	NNP
cord-307860-iqk1yiw4	516	27	on	on	IN
cord-307860-iqk1yiw4	516	28	receptors	receptor	NNS
cord-307860-iqk1yiw4	516	29	for	for	IN
cord-307860-iqk1yiw4	516	30	coronaviruses	coronaviruse	NNS
cord-307860-iqk1yiw4	516	31	with	with	IN
cord-307860-iqk1yiw4	516	32	special	special	JJ
cord-307860-iqk1yiw4	516	33	reference	reference	NN
cord-307860-iqk1yiw4	516	34	to	to	IN
cord-307860-iqk1yiw4	516	35	angiotensin	angiotensin	NN
cord-307860-iqk1yiw4	516	36	-	-	HYPH
cord-307860-iqk1yiw4	516	37	converting	convert	VBG
cord-307860-iqk1yiw4	516	38	enzyme	enzyme	NN
cord-307860-iqk1yiw4	516	39	2	2	CD
cord-307860-iqk1yiw4	516	40	as	as	IN
cord-307860-iqk1yiw4	516	41	a	a	DT
cord-307860-iqk1yiw4	516	42	potential	potential	JJ
cord-307860-iqk1yiw4	516	43	drug	drug	NN
cord-307860-iqk1yiw4	516	44	target	target	NN
cord-307860-iqk1yiw4	516	45	-a	-a	.
cord-307860-iqk1yiw4	517	1	perspective	perspective	NNP
cord-307860-iqk1yiw4	517	2	SARS	SARS	NNP
cord-307860-iqk1yiw4	517	3	-	-	HYPH
cord-307860-iqk1yiw4	517	4	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	517	5	receptor	receptor	NN
cord-307860-iqk1yiw4	517	6	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	517	7	is	be	VBZ
cord-307860-iqk1yiw4	517	8	an	an	DT
cord-307860-iqk1yiw4	517	9	interferon	interferon	NN
cord-307860-iqk1yiw4	517	10	-	-	HYPH
cord-307860-iqk1yiw4	517	11	stimulated	stimulate	VBN
cord-307860-iqk1yiw4	517	12	gene	gene	NN
cord-307860-iqk1yiw4	517	13	in	in	IN
cord-307860-iqk1yiw4	517	14	human	human	JJ
cord-307860-iqk1yiw4	517	15	airway	airway	NN
cord-307860-iqk1yiw4	517	16	epithelial	epithelial	JJ
cord-307860-iqk1yiw4	517	17	cells	cell	NNS
cord-307860-iqk1yiw4	517	18	and	and	CC
cord-307860-iqk1yiw4	517	19	is	be	VBZ
cord-307860-iqk1yiw4	517	20	detected	detect	VBN
cord-307860-iqk1yiw4	517	21	in	in	IN
cord-307860-iqk1yiw4	517	22	specific	specific	JJ
cord-307860-iqk1yiw4	517	23	cell	cell	NN
cord-307860-iqk1yiw4	517	24	subsets	subset	NNS
cord-307860-iqk1yiw4	517	25	across	across	IN
cord-307860-iqk1yiw4	517	26	tissues	tissue	NNS
cord-307860-iqk1yiw4	518	1	A	a	DT
cord-307860-iqk1yiw4	518	2	protein	protein	NN
cord-307860-iqk1yiw4	518	3	complex	complex	NN
cord-307860-iqk1yiw4	518	4	in	in	IN
cord-307860-iqk1yiw4	518	5	the	the	DT
cord-307860-iqk1yiw4	518	6	brush	brush	NN
cord-307860-iqk1yiw4	518	7	-	-	HYPH
cord-307860-iqk1yiw4	518	8	border	border	NN
cord-307860-iqk1yiw4	518	9	membrane	membrane	NN
cord-307860-iqk1yiw4	518	10	explains	explain	VBZ
cord-307860-iqk1yiw4	518	11	a	a	DT
cord-307860-iqk1yiw4	518	12	Hartnup	Hartnup	NNP
cord-307860-iqk1yiw4	518	13	disorder	disorder	NN
cord-307860-iqk1yiw4	518	14	allele	allele	NN
cord-307860-iqk1yiw4	519	1	Further	further	JJ
cord-307860-iqk1yiw4	519	2	evidence	evidence	NN
cord-307860-iqk1yiw4	519	3	for	for	IN
cord-307860-iqk1yiw4	519	4	allelic	allelic	JJ
cord-307860-iqk1yiw4	519	5	heterogeneity	heterogeneity	NN
cord-307860-iqk1yiw4	519	6	in	in	IN
cord-307860-iqk1yiw4	519	7	Hartnup	Hartnup	NNP
cord-307860-iqk1yiw4	519	8	disorder	disorder	NN
cord-307860-iqk1yiw4	519	9	Tissue	tissue	NN
cord-307860-iqk1yiw4	519	10	-	-	HYPH
cord-307860-iqk1yiw4	519	11	specific	specific	JJ
cord-307860-iqk1yiw4	519	12	amino	amino	NN
cord-307860-iqk1yiw4	519	13	acid	acid	NN
cord-307860-iqk1yiw4	519	14	transporter	transporter	NN
cord-307860-iqk1yiw4	519	15	partners	partner	NNS
cord-307860-iqk1yiw4	519	16	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	519	17	and	and	CC
cord-307860-iqk1yiw4	519	18	collectrin	collectrin	NNP
cord-307860-iqk1yiw4	519	19	differentially	differentially	RB
cord-307860-iqk1yiw4	519	20	interact	interact	VBP
cord-307860-iqk1yiw4	519	21	with	with	IN
cord-307860-iqk1yiw4	519	22	hartnup	hartnup	NNP
cord-307860-iqk1yiw4	519	23	mutations	mutation	NNS
cord-307860-iqk1yiw4	520	1	Molecular	molecular	JJ
cord-307860-iqk1yiw4	520	2	basis	basis	NN
cord-307860-iqk1yiw4	520	3	for	for	IN
cord-307860-iqk1yiw4	520	4	the	the	DT
cord-307860-iqk1yiw4	520	5	interaction	interaction	NN
cord-307860-iqk1yiw4	520	6	of	of	IN
cord-307860-iqk1yiw4	520	7	the	the	DT
cord-307860-iqk1yiw4	520	8	mammalian	mammalian	JJ
cord-307860-iqk1yiw4	520	9	amino	amino	NN
cord-307860-iqk1yiw4	520	10	acid	acid	NN
cord-307860-iqk1yiw4	520	11	transporters	transporter	NNS
cord-307860-iqk1yiw4	520	12	B0AT1	B0AT1	NNP
cord-307860-iqk1yiw4	520	13	and	and	CC
cord-307860-iqk1yiw4	520	14	B0AT3	B0AT3	NNP
cord-307860-iqk1yiw4	520	15	with	with	IN
cord-307860-iqk1yiw4	520	16	their	-PRON-	PRP$
cord-307860-iqk1yiw4	520	17	ancillary	ancillary	JJ
cord-307860-iqk1yiw4	520	18	protein	protein	NN
cord-307860-iqk1yiw4	520	19	collectrin	collectrin	NNP
cord-307860-iqk1yiw4	520	20	Expression	expression	NN
cord-307860-iqk1yiw4	520	21	and	and	CC
cord-307860-iqk1yiw4	520	22	regulation	regulation	NN
cord-307860-iqk1yiw4	520	23	of	of	IN
cord-307860-iqk1yiw4	520	24	the	the	DT
cord-307860-iqk1yiw4	520	25	neutral	neutral	JJ
cord-307860-iqk1yiw4	520	26	amino	amino	NN
cord-307860-iqk1yiw4	520	27	acid	acid	NN
cord-307860-iqk1yiw4	520	28	transporter	transporter	NN
cord-307860-iqk1yiw4	520	29	B0AT1	B0AT1	NNP
cord-307860-iqk1yiw4	520	30	in	in	IN
cord-307860-iqk1yiw4	520	31	rat	rat	NN
cord-307860-iqk1yiw4	520	32	small	small	JJ
cord-307860-iqk1yiw4	520	33	intestine	intestine	NN
cord-307860-iqk1yiw4	520	34	Epidermal	epidermal	JJ
cord-307860-iqk1yiw4	520	35	growth	growth	NN
cord-307860-iqk1yiw4	520	36	factor	factor	NN
cord-307860-iqk1yiw4	520	37	receptor	receptor	NN
cord-307860-iqk1yiw4	520	38	is	be	VBZ
cord-307860-iqk1yiw4	520	39	a	a	DT
cord-307860-iqk1yiw4	520	40	co	co	NN
cord-307860-iqk1yiw4	520	41	-	-	NN
cord-307860-iqk1yiw4	520	42	factor	factor	NN
cord-307860-iqk1yiw4	520	43	for	for	IN
cord-307860-iqk1yiw4	520	44	transmissible	transmissible	JJ
cord-307860-iqk1yiw4	520	45	gastroenteritis	gastroenteritis	JJ
cord-307860-iqk1yiw4	520	46	virus	virus	NN
cord-307860-iqk1yiw4	520	47	entry	entry	NN
cord-307860-iqk1yiw4	521	1	The	the	DT
cord-307860-iqk1yiw4	521	2	human	human	JJ
cord-307860-iqk1yiw4	521	3	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	521	4	HCoV-229E	HCoV-229E	NNP
cord-307860-iqk1yiw4	521	5	S	S	NNP
cord-307860-iqk1yiw4	521	6	-	-	HYPH
cord-307860-iqk1yiw4	521	7	protein	protein	NN
cord-307860-iqk1yiw4	521	8	structure	structure	NN
cord-307860-iqk1yiw4	521	9	and	and	CC
cord-307860-iqk1yiw4	521	10	receptor	receptor	NN
cord-307860-iqk1yiw4	521	11	binding	bind	VBG
cord-307860-iqk1yiw4	521	12	CD13	CD13	NNP
cord-307860-iqk1yiw4	521	13	(	(	-LRB-
cord-307860-iqk1yiw4	521	14	human	human	JJ
cord-307860-iqk1yiw4	521	15	aminopeptidase	aminopeptidase	NN
cord-307860-iqk1yiw4	521	16	N	n	CD
cord-307860-iqk1yiw4	521	17	)	)	-RRB-
cord-307860-iqk1yiw4	522	1	mediates	mediate	VBZ
cord-307860-iqk1yiw4	522	2	human	human	JJ
cord-307860-iqk1yiw4	522	3	cytomegalovirus	cytomegalovirus	NN
cord-307860-iqk1yiw4	522	4	infection	infection	NN
cord-307860-iqk1yiw4	522	5	Structure	Structure	NNP
cord-307860-iqk1yiw4	522	6	of	of	IN
cord-307860-iqk1yiw4	522	7	the	the	DT
cord-307860-iqk1yiw4	522	8	SARS	SARS	NNP
cord-307860-iqk1yiw4	522	9	-	-	HYPH
cord-307860-iqk1yiw4	522	10	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	522	11	spike	spike	NN
cord-307860-iqk1yiw4	522	12	receptor	receptor	NN
cord-307860-iqk1yiw4	522	13	-	-	HYPH
cord-307860-iqk1yiw4	522	14	binding	bind	VBG
cord-307860-iqk1yiw4	522	15	domain	domain	NN
cord-307860-iqk1yiw4	522	16	bound	bind	VBN
cord-307860-iqk1yiw4	522	17	to	to	IN
cord-307860-iqk1yiw4	522	18	the	the	DT
cord-307860-iqk1yiw4	522	19	ACE2	ACE2	NNP
cord-307860-iqk1yiw4	522	20	receptor	receptor	NN
cord-307860-iqk1yiw4	522	21	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	522	22	,	,	,
cord-307860-iqk1yiw4	522	23	an	an	DT
cord-307860-iqk1yiw4	522	24	emerging	emerge	VBG
cord-307860-iqk1yiw4	522	25	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	522	26	infection	infection	NN
cord-307860-iqk1yiw4	522	27	:	:	:
cord-307860-iqk1yiw4	522	28	advances	advance	NNS
cord-307860-iqk1yiw4	522	29	and	and	CC
cord-307860-iqk1yiw4	522	30	prospects	prospect	NNS
cord-307860-iqk1yiw4	522	31	in	in	IN
cord-307860-iqk1yiw4	522	32	designing	design	VBG
cord-307860-iqk1yiw4	522	33	and	and	CC
cord-307860-iqk1yiw4	522	34	developing	develop	VBG
cord-307860-iqk1yiw4	522	35	vaccines	vaccine	NNS
cord-307860-iqk1yiw4	522	36	,	,	,
cord-307860-iqk1yiw4	522	37	immunotherapeutics	immunotherapeutic	NNS
cord-307860-iqk1yiw4	522	38	,	,	,
cord-307860-iqk1yiw4	522	39	and	and	CC
cord-307860-iqk1yiw4	522	40	therapeutics	therapeutic	NNS
cord-307860-iqk1yiw4	522	41	.	.	.
cord-307860-iqk1yiw4	523	1	Hum	Hum	NNP
cord-307860-iqk1yiw4	523	2	Vaccines	Vaccines	NNPS
cord-307860-iqk1yiw4	523	3	Immunother	Immunother	NNP
cord-307860-iqk1yiw4	523	4	Structure	Structure	NNP
cord-307860-iqk1yiw4	523	5	of	of	IN
cord-307860-iqk1yiw4	523	6	the	the	DT
cord-307860-iqk1yiw4	523	7	S1	S1	NNP
cord-307860-iqk1yiw4	523	8	subunit	subunit	NN
cord-307860-iqk1yiw4	523	9	C	c	NN
cord-307860-iqk1yiw4	523	10	-	-	HYPH
cord-307860-iqk1yiw4	523	11	terminal	terminal	NN
cord-307860-iqk1yiw4	523	12	domain	domain	NN
cord-307860-iqk1yiw4	523	13	from	from	IN
cord-307860-iqk1yiw4	523	14	bat	bat	NN
cord-307860-iqk1yiw4	523	15	-	-	HYPH
cord-307860-iqk1yiw4	523	16	derived	derive	VBN
cord-307860-iqk1yiw4	523	17	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	523	18	HKU5	HKU5	NNP
cord-307860-iqk1yiw4	523	19	spike	spike	NN
cord-307860-iqk1yiw4	523	20	protein	protein	NN
cord-307860-iqk1yiw4	523	21	Immune	immune	NN
cord-307860-iqk1yiw4	523	22	-	-	HYPH
cord-307860-iqk1yiw4	523	23	epidemiological	epidemiological	JJ
cord-307860-iqk1yiw4	523	24	parameters	parameter	NNS
cord-307860-iqk1yiw4	523	25	of	of	IN
cord-307860-iqk1yiw4	523	26	the	the	DT
cord-307860-iqk1yiw4	523	27	novel	novel	JJ
cord-307860-iqk1yiw4	523	28	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	523	29	-	-	:
cord-307860-iqk1yiw4	523	30	a	a	DT
cord-307860-iqk1yiw4	523	31	perspective	perspective	NN
cord-307860-iqk1yiw4	523	32	A	a	DT
cord-307860-iqk1yiw4	523	33	retrospective	retrospective	JJ
cord-307860-iqk1yiw4	523	34	cohort	cohort	NN
cord-307860-iqk1yiw4	523	35	study	study	NN
cord-307860-iqk1yiw4	523	36	of	of	IN
cord-307860-iqk1yiw4	523	37	methylprednisolone	methylprednisolone	NNP
cord-307860-iqk1yiw4	523	38	therapy	therapy	NN
cord-307860-iqk1yiw4	523	39	in	in	IN
cord-307860-iqk1yiw4	523	40	severe	severe	JJ
cord-307860-iqk1yiw4	523	41	patients	patient	NNS
cord-307860-iqk1yiw4	523	42	with	with	IN
cord-307860-iqk1yiw4	523	43	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	523	44	pneumonia	pneumonia	NN
cord-307860-iqk1yiw4	524	1	The	the	DT
cord-307860-iqk1yiw4	524	2	immunobiology	immunobiology	NN
cord-307860-iqk1yiw4	524	3	of	of	IN
cord-307860-iqk1yiw4	524	4	SARS	SARS	NNP
cord-307860-iqk1yiw4	525	1	*	*	NFP
cord-307860-iqk1yiw4	525	2	Use	use	NN
cord-307860-iqk1yiw4	525	3	of	of	IN
cord-307860-iqk1yiw4	525	4	DAMPs	DAMPs	NNPS
cord-307860-iqk1yiw4	525	5	and	and	CC
cord-307860-iqk1yiw4	525	6	SAMPs	samp	NNS
cord-307860-iqk1yiw4	525	7	as	as	IN
cord-307860-iqk1yiw4	525	8	therapeutic	therapeutic	JJ
cord-307860-iqk1yiw4	525	9	targets	target	NNS
cord-307860-iqk1yiw4	525	10	or	or	CC
cord-307860-iqk1yiw4	525	11	therapeutics	therapeutic	NNS
cord-307860-iqk1yiw4	525	12	:	:	:
cord-307860-iqk1yiw4	525	13	a	a	DT
cord-307860-iqk1yiw4	525	14	note	note	NN
cord-307860-iqk1yiw4	525	15	of	of	IN
cord-307860-iqk1yiw4	525	16	caution	caution	NN
cord-307860-iqk1yiw4	525	17	Structural	structural	JJ
cord-307860-iqk1yiw4	525	18	basis	basis	NN
cord-307860-iqk1yiw4	525	19	of	of	IN
cord-307860-iqk1yiw4	525	20	neutralization	neutralization	NN
cord-307860-iqk1yiw4	525	21	by	by	IN
cord-307860-iqk1yiw4	525	22	a	a	DT
cord-307860-iqk1yiw4	525	23	human	human	JJ
cord-307860-iqk1yiw4	525	24	anti	anti	JJ
cord-307860-iqk1yiw4	525	25	-	-	JJ
cord-307860-iqk1yiw4	525	26	severe	severe	JJ
cord-307860-iqk1yiw4	525	27	acute	acute	JJ
cord-307860-iqk1yiw4	525	28	respiratory	respiratory	JJ
cord-307860-iqk1yiw4	525	29	syndrome	syndrome	NN
cord-307860-iqk1yiw4	525	30	spike	spike	NN
cord-307860-iqk1yiw4	525	31	protein	protein	NN
cord-307860-iqk1yiw4	525	32	antibody	antibody	NN
cord-307860-iqk1yiw4	525	33	,	,	,
cord-307860-iqk1yiw4	525	34	80R	80R	NNP
cord-307860-iqk1yiw4	526	1	An	an	DT
cord-307860-iqk1yiw4	526	2	"	"	``
cord-307860-iqk1yiw4	526	3	Old	old	JJ
cord-307860-iqk1yiw4	526	4	"	"	''
cord-307860-iqk1yiw4	526	5	protein	protein	NN
cord-307860-iqk1yiw4	526	6	with	with	IN
cord-307860-iqk1yiw4	526	7	a	a	DT
cord-307860-iqk1yiw4	526	8	new	new	JJ
cord-307860-iqk1yiw4	526	9	story	story	NN
cord-307860-iqk1yiw4	526	10	:	:	:
cord-307860-iqk1yiw4	527	1	coronavirus	coronavirus	NNP
cord-307860-iqk1yiw4	527	2	endoribonuclease	endoribonuclease	NNP
cord-307860-iqk1yiw4	527	3	is	be	VBZ
cord-307860-iqk1yiw4	527	4	important	important	JJ
cord-307860-iqk1yiw4	527	5	for	for	IN
cord-307860-iqk1yiw4	527	6	evading	evade	VBG
cord-307860-iqk1yiw4	527	7	host	host	NN
cord-307860-iqk1yiw4	527	8	antiviral	antiviral	JJ
cord-307860-iqk1yiw4	527	9	defenses	defense	NNS
cord-307860-iqk1yiw4	527	10	Signaling	signal	VBG
cord-307860-iqk1yiw4	527	11	to	to	IN
cord-307860-iqk1yiw4	527	12	NF	NF	NNP
cord-307860-iqk1yiw4	527	13	-	-	HYPH
cord-307860-iqk1yiw4	527	14	kappaB	kappaB	NNP
cord-307860-iqk1yiw4	527	15	by	by	IN
cord-307860-iqk1yiw4	527	16	tolllike	tolllike	NN
cord-307860-iqk1yiw4	527	17	receptors	receptor	NNS
cord-307860-iqk1yiw4	527	18	Non	non	JJ
cord-307860-iqk1yiw4	527	19	-	-	JJ
cord-307860-iqk1yiw4	527	20	catalytic	catalytic	JJ
cord-307860-iqk1yiw4	527	21	ubiquitin	ubiquitin	NN
cord-307860-iqk1yiw4	527	22	binding	binding	NN
cord-307860-iqk1yiw4	527	23	by	by	IN
cord-307860-iqk1yiw4	527	24	A20	A20	NNP
cord-307860-iqk1yiw4	527	25	prevents	prevent	VBZ
cord-307860-iqk1yiw4	527	26	psoriatic	psoriatic	JJ
cord-307860-iqk1yiw4	527	27	arthritis	arthritis	NN
cord-307860-iqk1yiw4	527	28	-	-	HYPH
cord-307860-iqk1yiw4	527	29	like	like	JJ
cord-307860-iqk1yiw4	527	30	disease	disease	NN
cord-307860-iqk1yiw4	527	31	and	and	CC
cord-307860-iqk1yiw4	527	32	inflammation	inflammation	NN
cord-307860-iqk1yiw4	528	1	The	the	DT
cord-307860-iqk1yiw4	528	2	use	use	NN
cord-307860-iqk1yiw4	528	3	of	of	IN
cord-307860-iqk1yiw4	528	4	anti	anti	JJ
cord-307860-iqk1yiw4	528	5	-	-	JJ
cord-307860-iqk1yiw4	528	6	inflammatory	inflammatory	JJ
cord-307860-iqk1yiw4	528	7	drugs	drug	NNS
cord-307860-iqk1yiw4	528	8	in	in	IN
cord-307860-iqk1yiw4	528	9	the	the	DT
cord-307860-iqk1yiw4	528	10	treatment	treatment	NN
cord-307860-iqk1yiw4	528	11	of	of	IN
cord-307860-iqk1yiw4	528	12	people	people	NNS
cord-307860-iqk1yiw4	528	13	with	with	IN
cord-307860-iqk1yiw4	528	14	severe	severe	JJ
cord-307860-iqk1yiw4	528	15	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	528	16	disease	disease	NN
cord-307860-iqk1yiw4	528	17	2019	2019	CD
cord-307860-iqk1yiw4	528	18	(	(	-LRB-
cord-307860-iqk1yiw4	528	19	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	528	20	)	)	-RRB-
cord-307860-iqk1yiw4	528	21	:	:	:
cord-307860-iqk1yiw4	528	22	the	the	DT
cord-307860-iqk1yiw4	528	23	perspectives	perspective	NNS
cord-307860-iqk1yiw4	528	24	of	of	IN
cord-307860-iqk1yiw4	528	25	clinical	clinical	JJ
cord-307860-iqk1yiw4	528	26	immunologists	immunologist	NNS
cord-307860-iqk1yiw4	528	27	from	from	IN
cord-307860-iqk1yiw4	528	28	China	China	NNP
cord-307860-iqk1yiw4	528	29	Nsp3	Nsp3	NNP
cord-307860-iqk1yiw4	528	30	of	of	IN
cord-307860-iqk1yiw4	528	31	coronaviruses	coronaviruse	NNS
cord-307860-iqk1yiw4	528	32	:	:	:
cord-307860-iqk1yiw4	529	1	structures	structure	NNS
cord-307860-iqk1yiw4	529	2	and	and	CC
cord-307860-iqk1yiw4	529	3	functions	function	NNS
cord-307860-iqk1yiw4	529	4	of	of	IN
cord-307860-iqk1yiw4	529	5	a	a	DT
cord-307860-iqk1yiw4	529	6	large	large	JJ
cord-307860-iqk1yiw4	529	7	multi	multi	JJ
cord-307860-iqk1yiw4	529	8	-	-	JJ
cord-307860-iqk1yiw4	529	9	domain	domain	NN
cord-307860-iqk1yiw4	529	10	protein	protein	NN
cord-307860-iqk1yiw4	529	11	Crystal	Crystal	NNP
cord-307860-iqk1yiw4	529	12	structure	structure	NN
cord-307860-iqk1yiw4	529	13	of	of	IN
cord-307860-iqk1yiw4	529	14	the	the	DT
cord-307860-iqk1yiw4	529	15	Middle	Middle	NNP
cord-307860-iqk1yiw4	529	16	East	East	NNP
cord-307860-iqk1yiw4	529	17	Respiratory	Respiratory	NNP
cord-307860-iqk1yiw4	529	18	Syndrome	Syndrome	NNP
cord-307860-iqk1yiw4	529	19	Coronavirus	Coronavirus	NNP
cord-307860-iqk1yiw4	529	20	(	(	-LRB-
cord-307860-iqk1yiw4	529	21	MERS	MERS	NNP
cord-307860-iqk1yiw4	529	22	-	-	HYPH
cord-307860-iqk1yiw4	529	23	CoV	CoV	NNP
cord-307860-iqk1yiw4	529	24	)	)	-RRB-
cord-307860-iqk1yiw4	529	25	papain	papain	NN
cord-307860-iqk1yiw4	529	26	-	-	HYPH
cord-307860-iqk1yiw4	529	27	like	like	JJ
cord-307860-iqk1yiw4	529	28	protease	protease	NN
cord-307860-iqk1yiw4	529	29	bound	bind	VBN
cord-307860-iqk1yiw4	529	30	to	to	IN
cord-307860-iqk1yiw4	529	31	ubiquitin	ubiquitin	NN
cord-307860-iqk1yiw4	529	32	facilitates	facilitate	VBZ
cord-307860-iqk1yiw4	529	33	targeted	target	VBN
cord-307860-iqk1yiw4	529	34	disruption	disruption	NN
cord-307860-iqk1yiw4	529	35	of	of	IN
cord-307860-iqk1yiw4	529	36	deubiquitinating	deubiquitinate	VBG
cord-307860-iqk1yiw4	529	37	activity	activity	NN
cord-307860-iqk1yiw4	529	38	to	to	TO
cord-307860-iqk1yiw4	529	39	demonstrate	demonstrate	VB
cord-307860-iqk1yiw4	529	40	its	-PRON-	PRP$
cord-307860-iqk1yiw4	529	41	role	role	NN
cord-307860-iqk1yiw4	529	42	in	in	IN
cord-307860-iqk1yiw4	529	43	innate	innate	JJ
cord-307860-iqk1yiw4	529	44	immune	immune	JJ
cord-307860-iqk1yiw4	529	45	suppression	suppression	NN
cord-307860-iqk1yiw4	529	46	Decoupling	decouple	VBG
cord-307860-iqk1yiw4	529	47	deISGylating	deisgylate	VBG
cord-307860-iqk1yiw4	529	48	and	and	CC
cord-307860-iqk1yiw4	529	49	deubiquitinating	deubiquitinating	NN
cord-307860-iqk1yiw4	529	50	activities	activity	NNS
cord-307860-iqk1yiw4	529	51	of	of	IN
cord-307860-iqk1yiw4	529	52	the	the	DT
cord-307860-iqk1yiw4	529	53	MERS	MERS	NNP
cord-307860-iqk1yiw4	529	54	virus	virus	NN
cord-307860-iqk1yiw4	530	1	papain	papain	NN
cord-307860-iqk1yiw4	530	2	-	-	HYPH
cord-307860-iqk1yiw4	530	3	like	like	JJ
cord-307860-iqk1yiw4	530	4	protease	protease	NN
cord-307860-iqk1yiw4	531	1	COVID-2019	COVID-2019	NNP
cord-307860-iqk1yiw4	531	2	:	:	:
cord-307860-iqk1yiw4	532	1	the	the	DT
cord-307860-iqk1yiw4	532	2	role	role	NN
cord-307860-iqk1yiw4	532	3	of	of	IN
cord-307860-iqk1yiw4	532	4	the	the	DT
cord-307860-iqk1yiw4	532	5	nsp2	nsp2	NN
cord-307860-iqk1yiw4	532	6	and	and	CC
cord-307860-iqk1yiw4	532	7	nsp3	nsp3	NNS
cord-307860-iqk1yiw4	532	8	in	in	IN
cord-307860-iqk1yiw4	532	9	its	-PRON-	PRP$
cord-307860-iqk1yiw4	532	10	pathogenesis	pathogenesis	NN
cord-307860-iqk1yiw4	532	11	Characterization	characterization	NN
cord-307860-iqk1yiw4	532	12	of	of	IN
cord-307860-iqk1yiw4	532	13	an	an	DT
cord-307860-iqk1yiw4	532	14	efficient	efficient	JJ
cord-307860-iqk1yiw4	532	15	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	532	16	ribosomal	ribosomal	NN
cord-307860-iqk1yiw4	532	17	frameshifting	frameshifte	VBG
cord-307860-iqk1yiw4	532	18	signal	signal	NN
cord-307860-iqk1yiw4	532	19	:	:	:
cord-307860-iqk1yiw4	532	20	requirement	requirement	NN
cord-307860-iqk1yiw4	532	21	for	for	IN
cord-307860-iqk1yiw4	532	22	an	an	DT
cord-307860-iqk1yiw4	532	23	RNA	RNA	NNP
cord-307860-iqk1yiw4	532	24	pseudoknot	pseudoknot	NN
cord-307860-iqk1yiw4	533	1	The	the	DT
cord-307860-iqk1yiw4	533	2	role	role	NN
cord-307860-iqk1yiw4	533	3	of	of	IN
cord-307860-iqk1yiw4	533	4	programmed-1	programmed-1	NNP
cord-307860-iqk1yiw4	533	5	ribosomal	ribosomal	JJ
cord-307860-iqk1yiw4	533	6	frameshifting	frameshifte	VBG
cord-307860-iqk1yiw4	533	7	in	in	IN
cord-307860-iqk1yiw4	533	8	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	533	9	propagation	propagation	NN
cord-307860-iqk1yiw4	534	1	The	the	DT
cord-307860-iqk1yiw4	534	2	proteins	protein	NNS
cord-307860-iqk1yiw4	534	3	of	of	IN
cord-307860-iqk1yiw4	534	4	severe	severe	JJ
cord-307860-iqk1yiw4	534	5	acute	acute	JJ
cord-307860-iqk1yiw4	534	6	respiratory	respiratory	JJ
cord-307860-iqk1yiw4	534	7	syndrome	syndrome	NN
cord-307860-iqk1yiw4	534	8	coronavirus-2	coronavirus-2	NN
cord-307860-iqk1yiw4	535	1	(	(	-LRB-
cord-307860-iqk1yiw4	535	2	SARS	SARS	NNP
cord-307860-iqk1yiw4	535	3	CoV-2	CoV-2	NNP
cord-307860-iqk1yiw4	535	4	or	or	CC
cord-307860-iqk1yiw4	535	5	n	n	NNP
cord-307860-iqk1yiw4	535	6	-	-	HYPH
cord-307860-iqk1yiw4	535	7	COV19	COV19	NNP
cord-307860-iqk1yiw4	535	8	)	)	-RRB-
cord-307860-iqk1yiw4	535	9	,	,	.
cord-307860-iqk1yiw4	536	1	the	the	DT
cord-307860-iqk1yiw4	536	2	Cause	Cause	NNP
cord-307860-iqk1yiw4	536	3	of	of	IN
cord-307860-iqk1yiw4	536	4	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	536	5	From	from	IN
cord-307860-iqk1yiw4	536	6	SARS	SARS	NNP
cord-307860-iqk1yiw4	536	7	to	to	IN
cord-307860-iqk1yiw4	536	8	MERS	MERS	NNP
cord-307860-iqk1yiw4	536	9	:	:	:
cord-307860-iqk1yiw4	537	1	crystallographic	crystallographic	JJ
cord-307860-iqk1yiw4	537	2	studies	study	NNS
cord-307860-iqk1yiw4	537	3	on	on	IN
cord-307860-iqk1yiw4	537	4	coronaviral	coronaviral	JJ
cord-307860-iqk1yiw4	537	5	proteases	protease	NNS
cord-307860-iqk1yiw4	537	6	enable	enable	VBP
cord-307860-iqk1yiw4	537	7	antiviral	antiviral	JJ
cord-307860-iqk1yiw4	537	8	drug	drug	NN
cord-307860-iqk1yiw4	537	9	design	design	NN
cord-307860-iqk1yiw4	537	10	Variable	variable	JJ
cord-307860-iqk1yiw4	537	11	oligomerization	oligomerization	NN
cord-307860-iqk1yiw4	537	12	modes	mode	NNS
cord-307860-iqk1yiw4	537	13	in	in	IN
cord-307860-iqk1yiw4	537	14	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	537	15	non	non	JJ
cord-307860-iqk1yiw4	537	16	-	-	JJ
cord-307860-iqk1yiw4	537	17	structural	structural	JJ
cord-307860-iqk1yiw4	537	18	protein	protein	NN
cord-307860-iqk1yiw4	537	19	9	9	CD
cord-307860-iqk1yiw4	537	20	Dimerization	Dimerization	NNP
cord-307860-iqk1yiw4	537	21	of	of	IN
cord-307860-iqk1yiw4	537	22	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	537	23	nsp9	nsp9	RB
cord-307860-iqk1yiw4	537	24	with	with	IN
cord-307860-iqk1yiw4	537	25	diverse	diverse	JJ
cord-307860-iqk1yiw4	537	26	modes	mode	NNS
cord-307860-iqk1yiw4	537	27	enhances	enhance	VBZ
cord-307860-iqk1yiw4	537	28	its	-PRON-	PRP$
cord-307860-iqk1yiw4	537	29	nucleic	nucleic	JJ
cord-307860-iqk1yiw4	537	30	acid	acid	NN
cord-307860-iqk1yiw4	537	31	binding	bind	VBG
cord-307860-iqk1yiw4	537	32	affinity	affinity	NN
cord-307860-iqk1yiw4	537	33	Porcine	Porcine	NNP
cord-307860-iqk1yiw4	537	34	deltacoronavirus	deltacoronavirus	NN
cord-307860-iqk1yiw4	538	1	nsp15	nsp15	NNP
cord-307860-iqk1yiw4	538	2	antagonizes	antagonize	VBZ
cord-307860-iqk1yiw4	538	3	interferon	interferon	NN
cord-307860-iqk1yiw4	538	4	-	-	HYPH
cord-307860-iqk1yiw4	538	5	beta	beta	NN
cord-307860-iqk1yiw4	538	6	production	production	NN
cord-307860-iqk1yiw4	538	7	independently	independently	RB
cord-307860-iqk1yiw4	538	8	of	of	IN
cord-307860-iqk1yiw4	539	1	its	-PRON-	PRP$
cord-307860-iqk1yiw4	539	2	endoribonuclease	endoribonuclease	NN
cord-307860-iqk1yiw4	539	3	activity	activity	NN
cord-307860-iqk1yiw4	539	4	Structural	structural	JJ
cord-307860-iqk1yiw4	539	5	and	and	CC
cord-307860-iqk1yiw4	539	6	biochemical	biochemical	JJ
cord-307860-iqk1yiw4	539	7	characterization	characterization	NN
cord-307860-iqk1yiw4	539	8	of	of	IN
cord-307860-iqk1yiw4	539	9	endoribonuclease	endoribonuclease	NNP
cord-307860-iqk1yiw4	539	10	Nsp15	Nsp15	NNP
cord-307860-iqk1yiw4	539	11	encoded	encode	VBN
cord-307860-iqk1yiw4	539	12	by	by	IN
cord-307860-iqk1yiw4	539	13	middle	middle	NNP
cord-307860-iqk1yiw4	539	14	east	east	NNP
cord-307860-iqk1yiw4	539	15	respiratory	respiratory	JJ
cord-307860-iqk1yiw4	539	16	syndrome	syndrome	NN
cord-307860-iqk1yiw4	539	17	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	539	18	Crystal	Crystal	NNP
cord-307860-iqk1yiw4	539	19	structure	structure	NN
cord-307860-iqk1yiw4	539	20	of	of	IN
cord-307860-iqk1yiw4	539	21	Nsp15	Nsp15	NNP
cord-307860-iqk1yiw4	539	22	endoribonuclease	endoribonuclease	NN
cord-307860-iqk1yiw4	539	23	NendoU	NendoU	NNP
cord-307860-iqk1yiw4	539	24	from	from	IN
cord-307860-iqk1yiw4	539	25	SARS	SARS	NNP
cord-307860-iqk1yiw4	539	26	-	-	HYPH
cord-307860-iqk1yiw4	539	27	CoV	CoV	NNP
cord-307860-iqk1yiw4	539	28	-2	-2	NNP
cord-307860-iqk1yiw4	539	29	Biophysical	Biophysical	NNP
cord-307860-iqk1yiw4	539	30	methods	method	NNS
cord-307860-iqk1yiw4	539	31	in	in	IN
cord-307860-iqk1yiw4	539	32	early	early	JJ
cord-307860-iqk1yiw4	539	33	drug	drug	NN
cord-307860-iqk1yiw4	539	34	discovery	discovery	NN
cord-307860-iqk1yiw4	540	1	The	the	DT
cord-307860-iqk1yiw4	540	2	devil	devil	NN
cord-307860-iqk1yiw4	540	3	is	be	VBZ
cord-307860-iqk1yiw4	540	4	still	still	RB
cord-307860-iqk1yiw4	540	5	in	in	IN
cord-307860-iqk1yiw4	540	6	the	the	DT
cord-307860-iqk1yiw4	540	7	details	detail	NNS
cord-307860-iqk1yiw4	540	8	-	-	:
cord-307860-iqk1yiw4	540	9	driving	drive	VBG
cord-307860-iqk1yiw4	540	10	early	early	JJ
cord-307860-iqk1yiw4	540	11	drug	drug	NN
cord-307860-iqk1yiw4	540	12	discovery	discovery	NN
cord-307860-iqk1yiw4	540	13	forward	forward	RB
cord-307860-iqk1yiw4	540	14	with	with	IN
cord-307860-iqk1yiw4	540	15	biophysical	biophysical	JJ
cord-307860-iqk1yiw4	540	16	experimental	experimental	JJ
cord-307860-iqk1yiw4	540	17	methods	method	NNS
cord-307860-iqk1yiw4	540	18	Pan	pan	JJ
cord-307860-iqk1yiw4	540	19	-	-	JJ
cord-307860-iqk1yiw4	540	20	viral	viral	JJ
cord-307860-iqk1yiw4	540	21	screening	screening	NN
cord-307860-iqk1yiw4	540	22	of	of	IN
cord-307860-iqk1yiw4	540	23	respiratory	respiratory	JJ
cord-307860-iqk1yiw4	540	24	tract	tract	NN
cord-307860-iqk1yiw4	540	25	infections	infection	NNS
cord-307860-iqk1yiw4	540	26	in	in	IN
cord-307860-iqk1yiw4	540	27	adults	adult	NNS
cord-307860-iqk1yiw4	540	28	with	with	IN
cord-307860-iqk1yiw4	540	29	and	and	CC
cord-307860-iqk1yiw4	540	30	without	without	IN
cord-307860-iqk1yiw4	540	31	asthma	asthma	NN
cord-307860-iqk1yiw4	540	32	reveals	reveal	VBZ
cord-307860-iqk1yiw4	540	33	unexpected	unexpected	JJ
cord-307860-iqk1yiw4	540	34	human	human	JJ
cord-307860-iqk1yiw4	540	35	coronavirus	coronavirus	NN
cord-307860-iqk1yiw4	540	36	and	and	CC
cord-307860-iqk1yiw4	540	37	human	human	JJ
cord-307860-iqk1yiw4	540	38	rhinovirus	rhinovirus	NN
cord-307860-iqk1yiw4	540	39	diversity	diversity	NN
cord-307860-iqk1yiw4	541	1	Why	why	WRB
cord-307860-iqk1yiw4	541	2	is	be	VBZ
cord-307860-iqk1yiw4	541	3	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	541	4	so	so	RB
cord-307860-iqk1yiw4	541	5	mild	mild	JJ
cord-307860-iqk1yiw4	541	6	in	in	IN
cord-307860-iqk1yiw4	541	7	children	child	NNS
cord-307860-iqk1yiw4	541	8	?	?	.
cord-307860-iqk1yiw4	542	1	Managing	manage	VBG
cord-307860-iqk1yiw4	542	2	childhood	childhood	NN
cord-307860-iqk1yiw4	542	3	allergies	allergy	NNS
cord-307860-iqk1yiw4	542	4	and	and	CC
cord-307860-iqk1yiw4	542	5	immunodeficiencies	immunodeficiency	NNS
cord-307860-iqk1yiw4	542	6	during	during	IN
cord-307860-iqk1yiw4	542	7	respiratory	respiratory	JJ
cord-307860-iqk1yiw4	542	8	virus	virus	NN
cord-307860-iqk1yiw4	542	9	epidemics	epidemic	NNS
cord-307860-iqk1yiw4	543	1	-the	-the	NFP
cord-307860-iqk1yiw4	544	1	2020	2020	CD
cord-307860-iqk1yiw4	545	1	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	545	2	pandemic	pandemic	NNP
cord-307860-iqk1yiw4	545	3	Publisher	Publisher	NNP
cord-307860-iqk1yiw4	545	4	's	's	POS
cord-307860-iqk1yiw4	545	5	Note	Note	NNP
cord-307860-iqk1yiw4	545	6	Springer	Springer	NNP
cord-307860-iqk1yiw4	545	7	Nature	Nature	NNP
cord-307860-iqk1yiw4	545	8	remains	remain	VBZ
cord-307860-iqk1yiw4	545	9	neutral	neutral	JJ
cord-307860-iqk1yiw4	545	10	with	with	IN
cord-307860-iqk1yiw4	545	11	regard	regard	NN
cord-307860-iqk1yiw4	545	12	to	to	IN
cord-307860-iqk1yiw4	545	13	jurisdictional	jurisdictional	JJ
cord-307860-iqk1yiw4	545	14	claims	claim	NNS
cord-307860-iqk1yiw4	545	15	in	in	IN
cord-307860-iqk1yiw4	545	16	published	publish	VBN
cord-307860-iqk1yiw4	545	17	maps	map	NNS
cord-307860-iqk1yiw4	545	18	and	and	CC
cord-307860-iqk1yiw4	545	19	institutional	institutional	JJ
cord-307860-iqk1yiw4	545	20	affiliations	affiliation	NNS
cord-307860-iqk1yiw4	545	21	Acknowledgements	acknowledgement	NNS
cord-307860-iqk1yiw4	546	1	Many	many	JJ
cord-307860-iqk1yiw4	546	2	thanks	thank	NNS
cord-307860-iqk1yiw4	546	3	to	to	IN
cord-307860-iqk1yiw4	546	4	the	the	DT
cord-307860-iqk1yiw4	546	5	Editorial	Editorial	NNP
cord-307860-iqk1yiw4	546	6	of	of	IN
cord-307860-iqk1yiw4	546	7	The	the	DT
cord-307860-iqk1yiw4	546	8	Protein	Protein	NNP
cord-307860-iqk1yiw4	546	9	Journal	Journal	NNP
cord-307860-iqk1yiw4	546	10	for	for	IN
cord-307860-iqk1yiw4	546	11	the	the	DT
cord-307860-iqk1yiw4	546	12	flexible	flexible	JJ
cord-307860-iqk1yiw4	546	13	approach	approach	NN
cord-307860-iqk1yiw4	546	14	during	during	IN
cord-307860-iqk1yiw4	546	15	the	the	DT
cord-307860-iqk1yiw4	546	16	COVID-19	COVID-19	NNP
cord-307860-iqk1yiw4	546	17	pandemic	pandemic	NN
cord-307860-iqk1yiw4	546	18	.	.	.
cord-307860-iqk1yiw4	547	1	I	-PRON-	PRP
cord-307860-iqk1yiw4	547	2	would	would	MD
cord-307860-iqk1yiw4	547	3	like	like	VB
cord-307860-iqk1yiw4	547	4	to	to	TO
cord-307860-iqk1yiw4	547	5	thank	thank	VB
cord-307860-iqk1yiw4	547	6	Professor	Professor	NNP
cord-307860-iqk1yiw4	547	7	Lawrence	Lawrence	NNP
cord-307860-iqk1yiw4	547	8	Berliner	Berliner	NNP
cord-307860-iqk1yiw4	547	9	and	and	CC
cord-307860-iqk1yiw4	547	10	the	the	DT
cord-307860-iqk1yiw4	547	11	referees	referee	NNS
cord-307860-iqk1yiw4	547	12	for	for	IN
cord-307860-iqk1yiw4	547	13	their	-PRON-	PRP$
cord-307860-iqk1yiw4	547	14	comments	comment	NNS
cord-307860-iqk1yiw4	547	15	that	that	IN
cord-307860-iqk1yiw4	547	16	much	much	RB
cord-307860-iqk1yiw4	547	17	improved	improve	VBD
cord-307860-iqk1yiw4	547	18	the	the	DT
cord-307860-iqk1yiw4	547	19	quality	quality	NN
cord-307860-iqk1yiw4	547	20	of	of	IN
cord-307860-iqk1yiw4	547	21	the	the	DT
cord-307860-iqk1yiw4	547	22	manuscript	manuscript	NN
cord-307860-iqk1yiw4	547	23	.	.	.
cord-307860-iqk1yiw4	548	1	Many	many	JJ
cord-307860-iqk1yiw4	548	2	thanks	thank	NNS
cord-307860-iqk1yiw4	548	3	to	to	IN
cord-307860-iqk1yiw4	548	4	Tudor	Tudor	NNP
cord-307860-iqk1yiw4	548	5	Constantin	Constantin	NNP
cord-307860-iqk1yiw4	548	6	Badea	Badea	NNP
cord-307860-iqk1yiw4	548	7	for	for	IN
cord-307860-iqk1yiw4	548	8	the	the	DT
cord-307860-iqk1yiw4	548	9	fruitful	fruitful	JJ
cord-307860-iqk1yiw4	548	10	discussions	discussion	NNS
cord-307860-iqk1yiw4	548	11	during	during	IN
cord-307860-iqk1yiw4	548	12	the	the	DT
cord-307860-iqk1yiw4	548	13	mobility	mobility	NN
cord-307860-iqk1yiw4	548	14	project	project	NN
cord-307860-iqk1yiw4	548	15	.	.	.
cord-307860-iqk1yiw4	548	16	 	 	_SP
cord-307860-iqk1yiw4	549	1	The	the	DT
cord-307860-iqk1yiw4	549	2	author	author	NN
cord-307860-iqk1yiw4	549	3	declares	declare	VBZ
cord-307860-iqk1yiw4	549	4	no	no	DT
cord-307860-iqk1yiw4	549	5	conflict	conflict	NN
cord-307860-iqk1yiw4	549	6	of	of	IN
cord-307860-iqk1yiw4	549	7	interest	interest	NN
cord-307860-iqk1yiw4	549	8	.	.	.
cord-307860-iqk1yiw4	550	1	The	the	DT
cord-307860-iqk1yiw4	550	2	funders	funder	NNS
cord-307860-iqk1yiw4	550	3	had	have	VBD
cord-307860-iqk1yiw4	550	4	no	no	DT
cord-307860-iqk1yiw4	550	5	role	role	NN
cord-307860-iqk1yiw4	550	6	in	in	IN
cord-307860-iqk1yiw4	550	7	the	the	DT
cord-307860-iqk1yiw4	550	8	design	design	NN
cord-307860-iqk1yiw4	550	9	of	of	IN
cord-307860-iqk1yiw4	550	10	the	the	DT
cord-307860-iqk1yiw4	550	11	study	study	NN
cord-307860-iqk1yiw4	550	12	;	;	:
cord-307860-iqk1yiw4	550	13	in	in	IN
cord-307860-iqk1yiw4	550	14	the	the	DT
cord-307860-iqk1yiw4	550	15	collection	collection	NN
cord-307860-iqk1yiw4	550	16	,	,	,
cord-307860-iqk1yiw4	550	17	analyses	analysis	NNS
cord-307860-iqk1yiw4	550	18	,	,	,
cord-307860-iqk1yiw4	550	19	or	or	CC
cord-307860-iqk1yiw4	550	20	interpretation	interpretation	NN
cord-307860-iqk1yiw4	550	21	of	of	IN
cord-307860-iqk1yiw4	550	22	data	datum	NNS
cord-307860-iqk1yiw4	550	23	;	;	:
cord-307860-iqk1yiw4	550	24	in	in	IN
cord-307860-iqk1yiw4	550	25	the	the	DT
cord-307860-iqk1yiw4	550	26	writing	writing	NN
cord-307860-iqk1yiw4	550	27	of	of	IN
cord-307860-iqk1yiw4	550	28	the	the	DT
cord-307860-iqk1yiw4	550	29	manuscript	manuscript	NN
cord-307860-iqk1yiw4	550	30	,	,	,
cord-307860-iqk1yiw4	550	31	or	or	CC
cord-307860-iqk1yiw4	550	32	in	in	IN
cord-307860-iqk1yiw4	550	33	the	the	DT
cord-307860-iqk1yiw4	550	34	decision	decision	NN
cord-307860-iqk1yiw4	550	35	to	to	TO
cord-307860-iqk1yiw4	550	36	publish	publish	VB
cord-307860-iqk1yiw4	550	37	the	the	DT
cord-307860-iqk1yiw4	550	38	results	result	NNS
cord-307860-iqk1yiw4	550	39	.	.	.