id	sid	tid	token	lemma	pos
cord-259603-bh198xgl	1	1	key	key	JJ
cord-259603-bh198xgl	1	2	:	:	:
cord-259603-bh198xgl	1	3	cord-259603-bh198xgl	cord-259603-bh198xgl	NN
cord-259603-bh198xgl	1	4	authors	author	NNS
cord-259603-bh198xgl	1	5	:	:	:
cord-259603-bh198xgl	1	6	Snijder	Snijder	NNP
cord-259603-bh198xgl	1	7	,	,	,
cord-259603-bh198xgl	1	8	E.J.	E.J.	NNP
cord-259603-bh198xgl	1	9	;	;	:
cord-259603-bh198xgl	1	10	Decroly	Decroly	NNP
cord-259603-bh198xgl	1	11	,	,	,
cord-259603-bh198xgl	1	12	E.	E.	NNP
cord-259603-bh198xgl	1	13	;	;	:
cord-259603-bh198xgl	1	14	Ziebuhr	Ziebuhr	NNP
cord-259603-bh198xgl	1	15	,	,	,
cord-259603-bh198xgl	1	16	J.	J.	NNP
cord-259603-bh198xgl	1	17	title	title	NN
cord-259603-bh198xgl	1	18	:	:	:
cord-259603-bh198xgl	1	19	The	the	DT
cord-259603-bh198xgl	1	20	Nonstructural	nonstructural	JJ
cord-259603-bh198xgl	1	21	Proteins	protein	NNS
cord-259603-bh198xgl	1	22	Directing	direct	VBG
cord-259603-bh198xgl	1	23	Coronavirus	Coronavirus	NNP
cord-259603-bh198xgl	1	24	RNA	RNA	NNP
cord-259603-bh198xgl	1	25	Synthesis	Synthesis	NNP
cord-259603-bh198xgl	1	26	and	and	CC
cord-259603-bh198xgl	1	27	Processing	Processing	NNP
cord-259603-bh198xgl	1	28	date	date	NN
cord-259603-bh198xgl	1	29	:	:	:
cord-259603-bh198xgl	1	30	2016	2016	CD
cord-259603-bh198xgl	1	31	-	-	HYPH
cord-259603-bh198xgl	1	32	09	09	CD
cord-259603-bh198xgl	1	33	-	-	SYM
cord-259603-bh198xgl	1	34	14	14	CD
cord-259603-bh198xgl	1	35	journal	journal	NN
cord-259603-bh198xgl	1	36	:	:	:
cord-259603-bh198xgl	2	1	Adv	Adv	NNP
cord-259603-bh198xgl	2	2	Virus	virus	NN
cord-259603-bh198xgl	2	3	Res	res	NN
cord-259603-bh198xgl	2	4	DOI	doi	NN
cord-259603-bh198xgl	2	5	:	:	:
cord-259603-bh198xgl	3	1	10.1016/	10.1016/	CD
cord-259603-bh198xgl	4	1	bs.aivir.2016.08.008	bs.aivir.2016.08.008	NNP
cord-259603-bh198xgl	5	1	sha	sha	NNP
cord-259603-bh198xgl	5	2	:	:	:
cord-259603-bh198xgl	5	3	2f907204bfc5354c091a17133e85c41e50a0b8d7	2f907204bfc5354c091a17133e85c41e50a0b8d7	CD
cord-259603-bh198xgl	5	4	doc_id	doc_id	CD
cord-259603-bh198xgl	5	5	:	:	:
cord-259603-bh198xgl	5	6	259603	259603	CD
cord-259603-bh198xgl	6	1	cord_uid	cord_uid	NN
cord-259603-bh198xgl	6	2	:	:	:
cord-259603-bh198xgl	7	1	bh198xgl	bh198xgl	NNP
cord-259603-bh198xgl	7	2	Coronaviruses	Coronaviruses	NNPS
cord-259603-bh198xgl	7	3	are	be	VBP
cord-259603-bh198xgl	7	4	animal	animal	NN
cord-259603-bh198xgl	7	5	and	and	CC
cord-259603-bh198xgl	7	6	human	human	JJ
cord-259603-bh198xgl	7	7	pathogens	pathogen	NNS
cord-259603-bh198xgl	7	8	that	that	WDT
cord-259603-bh198xgl	7	9	can	can	MD
cord-259603-bh198xgl	7	10	cause	cause	VB
cord-259603-bh198xgl	7	11	lethal	lethal	JJ
cord-259603-bh198xgl	7	12	zoonotic	zoonotic	JJ
cord-259603-bh198xgl	7	13	infections	infection	NNS
cord-259603-bh198xgl	7	14	like	like	IN
cord-259603-bh198xgl	7	15	SARS	SARS	NNP
cord-259603-bh198xgl	7	16	and	and	CC
cord-259603-bh198xgl	7	17	MERS	MERS	NNP
cord-259603-bh198xgl	7	18	.	.	.
cord-259603-bh198xgl	8	1	They	-PRON-	PRP
cord-259603-bh198xgl	8	2	have	have	VBP
cord-259603-bh198xgl	8	3	polycistronic	polycistronic	JJ
cord-259603-bh198xgl	8	4	plus	plus	RB
cord-259603-bh198xgl	8	5	-	-	HYPH
cord-259603-bh198xgl	8	6	stranded	strand	VBN
cord-259603-bh198xgl	8	7	RNA	RNA	NNP
cord-259603-bh198xgl	8	8	genomes	genome	NNS
cord-259603-bh198xgl	8	9	and	and	CC
cord-259603-bh198xgl	8	10	belong	belong	VBP
cord-259603-bh198xgl	8	11	to	to	IN
cord-259603-bh198xgl	8	12	the	the	DT
cord-259603-bh198xgl	8	13	order	order	NN
cord-259603-bh198xgl	8	14	Nidovirales	Nidovirales	NNP
cord-259603-bh198xgl	8	15	,	,	,
cord-259603-bh198xgl	8	16	a	a	DT
cord-259603-bh198xgl	8	17	diverse	diverse	JJ
cord-259603-bh198xgl	8	18	group	group	NN
cord-259603-bh198xgl	8	19	of	of	IN
cord-259603-bh198xgl	8	20	viruses	virus	NNS
cord-259603-bh198xgl	8	21	for	for	IN
cord-259603-bh198xgl	8	22	which	which	WDT
cord-259603-bh198xgl	8	23	common	common	JJ
cord-259603-bh198xgl	8	24	ancestry	ancestry	NN
cord-259603-bh198xgl	8	25	was	be	VBD
cord-259603-bh198xgl	8	26	inferred	infer	VBN
cord-259603-bh198xgl	8	27	from	from	IN
cord-259603-bh198xgl	8	28	the	the	DT
cord-259603-bh198xgl	8	29	common	common	JJ
cord-259603-bh198xgl	8	30	principles	principle	NNS
cord-259603-bh198xgl	8	31	underlying	underlie	VBG
cord-259603-bh198xgl	8	32	their	-PRON-	PRP$
cord-259603-bh198xgl	8	33	genome	genome	NN
cord-259603-bh198xgl	8	34	organization	organization	NN
cord-259603-bh198xgl	8	35	and	and	CC
cord-259603-bh198xgl	8	36	expression	expression	NN
cord-259603-bh198xgl	8	37	,	,	,
cord-259603-bh198xgl	8	38	and	and	CC
cord-259603-bh198xgl	8	39	from	from	IN
cord-259603-bh198xgl	8	40	the	the	DT
cord-259603-bh198xgl	8	41	conservation	conservation	NN
cord-259603-bh198xgl	8	42	of	of	IN
cord-259603-bh198xgl	8	43	an	an	DT
cord-259603-bh198xgl	8	44	array	array	NN
cord-259603-bh198xgl	8	45	of	of	IN
cord-259603-bh198xgl	8	46	core	core	JJ
cord-259603-bh198xgl	8	47	replicase	replicase	NN
cord-259603-bh198xgl	8	48	domains	domain	NNS
cord-259603-bh198xgl	8	49	,	,	,
cord-259603-bh198xgl	8	50	including	include	VBG
cord-259603-bh198xgl	8	51	key	key	JJ
cord-259603-bh198xgl	8	52	RNA	RNA	NNP
cord-259603-bh198xgl	8	53	-	-	HYPH
cord-259603-bh198xgl	8	54	synthesizing	synthesize	VBG
cord-259603-bh198xgl	8	55	enzymes	enzyme	NNS
cord-259603-bh198xgl	8	56	.	.	.
cord-259603-bh198xgl	9	1	Coronavirus	Coronavirus	NNP
cord-259603-bh198xgl	9	2	genomes	genome	NNS
cord-259603-bh198xgl	9	3	(	(	-LRB-
cord-259603-bh198xgl	9	4	~	~	NFP
cord-259603-bh198xgl	9	5	26–32	26–32	CD
cord-259603-bh198xgl	9	6	kilobases	kilobases	NNP
cord-259603-bh198xgl	9	7	)	)	-RRB-
cord-259603-bh198xgl	9	8	are	be	VBP
cord-259603-bh198xgl	9	9	the	the	DT
cord-259603-bh198xgl	9	10	largest	large	JJS
cord-259603-bh198xgl	9	11	RNA	RNA	NNP
cord-259603-bh198xgl	9	12	genomes	genome	NNS
cord-259603-bh198xgl	9	13	known	know	VBN
cord-259603-bh198xgl	9	14	to	to	IN
cord-259603-bh198xgl	9	15	date	date	NN
cord-259603-bh198xgl	9	16	and	and	CC
cord-259603-bh198xgl	9	17	their	-PRON-	PRP$
cord-259603-bh198xgl	9	18	expansion	expansion	NN
cord-259603-bh198xgl	9	19	was	be	VBD
cord-259603-bh198xgl	9	20	likely	likely	RB
cord-259603-bh198xgl	9	21	enabled	enable	VBN
cord-259603-bh198xgl	9	22	by	by	IN
cord-259603-bh198xgl	9	23	acquiring	acquire	VBG
cord-259603-bh198xgl	9	24	enzyme	enzyme	NN
cord-259603-bh198xgl	9	25	functions	function	NNS
cord-259603-bh198xgl	9	26	that	that	WDT
cord-259603-bh198xgl	9	27	counter	counter	VBP
cord-259603-bh198xgl	9	28	the	the	DT
cord-259603-bh198xgl	9	29	commonly	commonly	RB
cord-259603-bh198xgl	9	30	high	high	JJ
cord-259603-bh198xgl	9	31	error	error	NN
cord-259603-bh198xgl	9	32	frequency	frequency	NN
cord-259603-bh198xgl	9	33	of	of	IN
cord-259603-bh198xgl	9	34	viral	viral	JJ
cord-259603-bh198xgl	9	35	RNA	RNA	NNP
cord-259603-bh198xgl	9	36	polymerases	polymerase	NNS
cord-259603-bh198xgl	9	37	.	.	.
cord-259603-bh198xgl	10	1	The	the	DT
cord-259603-bh198xgl	10	2	primary	primary	JJ
cord-259603-bh198xgl	10	3	functions	function	NNS
cord-259603-bh198xgl	10	4	that	that	WDT
cord-259603-bh198xgl	10	5	direct	direct	JJ
cord-259603-bh198xgl	10	6	coronavirus	coronavirus	NN
cord-259603-bh198xgl	10	7	RNA	rna	NN
cord-259603-bh198xgl	10	8	synthesis	synthesis	NN
cord-259603-bh198xgl	10	9	and	and	CC
cord-259603-bh198xgl	10	10	processing	processing	NN
cord-259603-bh198xgl	10	11	reside	reside	VBP
cord-259603-bh198xgl	10	12	in	in	IN
cord-259603-bh198xgl	10	13	nonstructural	nonstructural	JJ
cord-259603-bh198xgl	10	14	protein	protein	NN
cord-259603-bh198xgl	10	15	(	(	-LRB-
cord-259603-bh198xgl	10	16	nsp	nsp	NNP
cord-259603-bh198xgl	10	17	)	)	-RRB-
cord-259603-bh198xgl	10	18	7	7	CD
cord-259603-bh198xgl	10	19	to	to	IN
cord-259603-bh198xgl	10	20	nsp16	nsp16	NNS
cord-259603-bh198xgl	10	21	,	,	,
cord-259603-bh198xgl	10	22	which	which	WDT
cord-259603-bh198xgl	10	23	are	be	VBP
cord-259603-bh198xgl	10	24	cleavage	cleavage	NN
cord-259603-bh198xgl	10	25	products	product	NNS
cord-259603-bh198xgl	10	26	of	of	IN
cord-259603-bh198xgl	10	27	two	two	CD
cord-259603-bh198xgl	10	28	large	large	JJ
cord-259603-bh198xgl	10	29	replicase	replicase	NN
cord-259603-bh198xgl	10	30	polyproteins	polyprotein	NNS
cord-259603-bh198xgl	10	31	translated	translate	VBN
cord-259603-bh198xgl	10	32	from	from	IN
cord-259603-bh198xgl	10	33	the	the	DT
cord-259603-bh198xgl	10	34	coronavirus	coronavirus	NN
cord-259603-bh198xgl	10	35	genome	genome	NN
cord-259603-bh198xgl	10	36	.	.	.
cord-259603-bh198xgl	11	1	Significant	significant	JJ
cord-259603-bh198xgl	11	2	progress	progress	NN
cord-259603-bh198xgl	11	3	has	have	VBZ
cord-259603-bh198xgl	11	4	now	now	RB
cord-259603-bh198xgl	11	5	been	be	VBN
cord-259603-bh198xgl	11	6	made	make	VBN
cord-259603-bh198xgl	11	7	regarding	regard	VBG
cord-259603-bh198xgl	11	8	their	-PRON-	PRP$
cord-259603-bh198xgl	11	9	structural	structural	JJ
cord-259603-bh198xgl	11	10	and	and	CC
cord-259603-bh198xgl	11	11	functional	functional	JJ
cord-259603-bh198xgl	11	12	characterization	characterization	NN
cord-259603-bh198xgl	11	13	,	,	,
cord-259603-bh198xgl	11	14	stimulated	stimulate	VBN
cord-259603-bh198xgl	11	15	by	by	IN
cord-259603-bh198xgl	11	16	technical	technical	JJ
cord-259603-bh198xgl	11	17	advances	advance	NNS
cord-259603-bh198xgl	11	18	like	like	IN
cord-259603-bh198xgl	11	19	improved	improve	VBN
cord-259603-bh198xgl	11	20	methods	method	NNS
cord-259603-bh198xgl	11	21	for	for	IN
cord-259603-bh198xgl	11	22	bioinformatics	bioinformatic	NNS
cord-259603-bh198xgl	11	23	and	and	CC
cord-259603-bh198xgl	11	24	structural	structural	JJ
cord-259603-bh198xgl	11	25	biology	biology	NN
cord-259603-bh198xgl	11	26	,	,	,
cord-259603-bh198xgl	11	27	in	in	IN
cord-259603-bh198xgl	11	28	vitro	vitro	FW
cord-259603-bh198xgl	11	29	enzyme	enzyme	NN
cord-259603-bh198xgl	11	30	characterization	characterization	NN
cord-259603-bh198xgl	11	31	,	,	,
cord-259603-bh198xgl	11	32	and	and	CC
cord-259603-bh198xgl	11	33	site	site	NN
cord-259603-bh198xgl	11	34	-	-	HYPH
cord-259603-bh198xgl	11	35	directed	direct	VBN
cord-259603-bh198xgl	11	36	mutagenesis	mutagenesis	NN
cord-259603-bh198xgl	11	37	of	of	IN
cord-259603-bh198xgl	11	38	coronavirus	coronavirus	NN
cord-259603-bh198xgl	11	39	genomes	genome	NNS
cord-259603-bh198xgl	11	40	.	.	.
cord-259603-bh198xgl	12	1	Coronavirus	Coronavirus	NNP
cord-259603-bh198xgl	12	2	replicase	replicase	NN
cord-259603-bh198xgl	12	3	functions	function	NNS
cord-259603-bh198xgl	12	4	include	include	VBP
cord-259603-bh198xgl	12	5	more	more	RBR
cord-259603-bh198xgl	12	6	or	or	CC
cord-259603-bh198xgl	12	7	less	less	RBR
cord-259603-bh198xgl	12	8	universal	universal	JJ
cord-259603-bh198xgl	12	9	activities	activity	NNS
cord-259603-bh198xgl	12	10	of	of	IN
cord-259603-bh198xgl	12	11	plus	plus	NN
cord-259603-bh198xgl	12	12	-	-	HYPH
cord-259603-bh198xgl	12	13	stranded	strand	VBN
cord-259603-bh198xgl	12	14	RNA	RNA	NNP
cord-259603-bh198xgl	12	15	viruses	virus	NNS
cord-259603-bh198xgl	12	16	,	,	,
cord-259603-bh198xgl	12	17	like	like	IN
cord-259603-bh198xgl	12	18	an	an	DT
cord-259603-bh198xgl	12	19	RNA	RNA	NNP
cord-259603-bh198xgl	12	20	polymerase	polymerase	NN
cord-259603-bh198xgl	12	21	(	(	-LRB-
cord-259603-bh198xgl	12	22	nsp12	nsp12	CD
cord-259603-bh198xgl	12	23	)	)	-RRB-
cord-259603-bh198xgl	12	24	and	and	CC
cord-259603-bh198xgl	12	25	helicase	helicase	NNP
cord-259603-bh198xgl	12	26	(	(	-LRB-
cord-259603-bh198xgl	12	27	nsp13	nsp13	NNP
cord-259603-bh198xgl	12	28	)	)	-RRB-
cord-259603-bh198xgl	12	29	,	,	,
cord-259603-bh198xgl	12	30	but	but	CC
cord-259603-bh198xgl	12	31	also	also	RB
cord-259603-bh198xgl	12	32	a	a	DT
cord-259603-bh198xgl	12	33	number	number	NN
cord-259603-bh198xgl	12	34	of	of	IN
cord-259603-bh198xgl	12	35	rare	rare	JJ
cord-259603-bh198xgl	12	36	or	or	CC
cord-259603-bh198xgl	12	37	even	even	RB
cord-259603-bh198xgl	12	38	unique	unique	JJ
cord-259603-bh198xgl	12	39	domains	domain	NNS
cord-259603-bh198xgl	12	40	involved	involve	VBN
cord-259603-bh198xgl	12	41	in	in	IN
cord-259603-bh198xgl	12	42	mRNA	mrna	NN
cord-259603-bh198xgl	12	43	capping	cap	VBG
cord-259603-bh198xgl	12	44	(	(	-LRB-
cord-259603-bh198xgl	12	45	nsp14	nsp14	NN
cord-259603-bh198xgl	12	46	,	,	,
cord-259603-bh198xgl	12	47	nsp16	nsp16	NNS
cord-259603-bh198xgl	12	48	)	)	-RRB-
cord-259603-bh198xgl	12	49	and	and	CC
cord-259603-bh198xgl	12	50	fidelity	fidelity	NNP
cord-259603-bh198xgl	12	51	control	control	NN
cord-259603-bh198xgl	12	52	(	(	-LRB-
cord-259603-bh198xgl	12	53	nsp14	nsp14	NNP
cord-259603-bh198xgl	12	54	)	)	-RRB-
cord-259603-bh198xgl	12	55	.	.	.
cord-259603-bh198xgl	13	1	Several	several	JJ
cord-259603-bh198xgl	13	2	smaller	small	JJR
cord-259603-bh198xgl	13	3	subunits	subunit	NNS
cord-259603-bh198xgl	13	4	(	(	-LRB-
cord-259603-bh198xgl	13	5	nsp7–nsp10	nsp7–nsp10	RB
cord-259603-bh198xgl	13	6	)	)	-RRB-
cord-259603-bh198xgl	13	7	act	act	VB
cord-259603-bh198xgl	13	8	as	as	IN
cord-259603-bh198xgl	13	9	crucial	crucial	JJ
cord-259603-bh198xgl	13	10	cofactors	cofactor	NNS
cord-259603-bh198xgl	13	11	of	of	IN
cord-259603-bh198xgl	13	12	these	these	DT
cord-259603-bh198xgl	13	13	enzymes	enzyme	NNS
cord-259603-bh198xgl	13	14	and	and	CC
cord-259603-bh198xgl	13	15	contribute	contribute	VBP
cord-259603-bh198xgl	13	16	to	to	IN
cord-259603-bh198xgl	13	17	the	the	DT
cord-259603-bh198xgl	13	18	emerging	emerge	VBG
cord-259603-bh198xgl	13	19	“	"	``
cord-259603-bh198xgl	13	20	nsp	nsp	NNP
cord-259603-bh198xgl	13	21	interactome	interactome	NNP
cord-259603-bh198xgl	13	22	.	.	.
cord-259603-bh198xgl	13	23	”	"	''
cord-259603-bh198xgl	14	1	Understanding	understand	VBG
cord-259603-bh198xgl	14	2	the	the	DT
cord-259603-bh198xgl	14	3	structure	structure	NN
cord-259603-bh198xgl	14	4	,	,	,
cord-259603-bh198xgl	14	5	function	function	NN
cord-259603-bh198xgl	14	6	,	,	,
cord-259603-bh198xgl	14	7	and	and	CC
cord-259603-bh198xgl	14	8	interactions	interaction	NNS
cord-259603-bh198xgl	14	9	of	of	IN
cord-259603-bh198xgl	14	10	the	the	DT
cord-259603-bh198xgl	14	11	RNA	RNA	NNP
cord-259603-bh198xgl	14	12	-	-	HYPH
cord-259603-bh198xgl	14	13	synthesizing	synthesize	VBG
cord-259603-bh198xgl	14	14	machinery	machinery	NN
cord-259603-bh198xgl	14	15	of	of	IN
cord-259603-bh198xgl	14	16	coronaviruses	coronaviruse	NNS
cord-259603-bh198xgl	14	17	will	will	MD
cord-259603-bh198xgl	14	18	be	be	VB
cord-259603-bh198xgl	14	19	key	key	JJ
cord-259603-bh198xgl	14	20	to	to	IN
cord-259603-bh198xgl	14	21	rationalizing	rationalize	VBG
cord-259603-bh198xgl	14	22	their	-PRON-	PRP$
cord-259603-bh198xgl	14	23	evolutionary	evolutionary	JJ
cord-259603-bh198xgl	14	24	success	success	NN
cord-259603-bh198xgl	14	25	and	and	CC
cord-259603-bh198xgl	14	26	the	the	DT
cord-259603-bh198xgl	14	27	development	development	NN
cord-259603-bh198xgl	14	28	of	of	IN
cord-259603-bh198xgl	14	29	improved	improved	JJ
cord-259603-bh198xgl	14	30	control	control	NN
cord-259603-bh198xgl	14	31	strategies	strategy	NNS
cord-259603-bh198xgl	14	32	.	.	.
cord-259603-bh198xgl	15	1	Coronaviruses	Coronaviruses	NNP
cord-259603-bh198xgl	15	2	(	(	-LRB-
cord-259603-bh198xgl	15	3	CoVs	CoVs	NNP
cord-259603-bh198xgl	15	4	)	)	-RRB-
cord-259603-bh198xgl	15	5	are	be	VBP
cord-259603-bh198xgl	15	6	the	the	DT
cord-259603-bh198xgl	15	7	best	well	RBS
cord-259603-bh198xgl	15	8	-	-	HYPH
cord-259603-bh198xgl	15	9	known	know	VBN
cord-259603-bh198xgl	15	10	and	and	CC
cord-259603-bh198xgl	15	11	best	well	RBS
cord-259603-bh198xgl	15	12	-	-	HYPH
cord-259603-bh198xgl	15	13	studied	study	VBN
cord-259603-bh198xgl	15	14	clade	clade	NN
cord-259603-bh198xgl	15	15	of	of	IN
cord-259603-bh198xgl	15	16	the	the	DT
cord-259603-bh198xgl	15	17	order	order	NN
cord-259603-bh198xgl	15	18	Nidovirales	Nidovirales	NNP
cord-259603-bh198xgl	15	19	,	,	,
cord-259603-bh198xgl	15	20	which	which	WDT
cord-259603-bh198xgl	15	21	is	be	VBZ
cord-259603-bh198xgl	15	22	comprised	comprise	VBN
cord-259603-bh198xgl	15	23	of	of	IN
cord-259603-bh198xgl	15	24	enveloped	envelop	VBN
cord-259603-bh198xgl	15	25	plus	plus	CC
cord-259603-bh198xgl	15	26	-	-	HYPH
cord-259603-bh198xgl	15	27	stranded	strand	VBN
cord-259603-bh198xgl	15	28	(	(	-LRB-
cord-259603-bh198xgl	15	29	+	+	CC
cord-259603-bh198xgl	15	30	RNA	RNA	NNP
cord-259603-bh198xgl	15	31	)	)	-RRB-
cord-259603-bh198xgl	15	32	viruses	virus	NNS
cord-259603-bh198xgl	15	33	and	and	CC
cord-259603-bh198xgl	15	34	currently	currently	RB
cord-259603-bh198xgl	15	35	also	also	RB
cord-259603-bh198xgl	15	36	comprises	comprise	VBZ
cord-259603-bh198xgl	15	37	the	the	DT
cord-259603-bh198xgl	15	38	Arteriviridae	Arteriviridae	NNP
cord-259603-bh198xgl	15	39	,	,	,
cord-259603-bh198xgl	15	40	Roniviridae	Roniviridae	NNP
cord-259603-bh198xgl	15	41	,	,	,
cord-259603-bh198xgl	15	42	and	and	CC
cord-259603-bh198xgl	15	43	Mesoniviridae	Mesoniviridae	NNP
cord-259603-bh198xgl	15	44	families	family	NNS
cord-259603-bh198xgl	15	45	(	(	-LRB-
cord-259603-bh198xgl	15	46	de	de	FW
cord-259603-bh198xgl	15	47	Groot	Groot	NNP
cord-259603-bh198xgl	15	48	et	et	FW
cord-259603-bh198xgl	15	49	al	al	NNP
cord-259603-bh198xgl	15	50	.	.	NNP
cord-259603-bh198xgl	15	51	,	,	,
cord-259603-bh198xgl	15	52	2012a	2012a	CD
cord-259603-bh198xgl	15	53	,	,	,
cord-259603-bh198xgl	15	54	b	b	LS
cord-259603-bh198xgl	15	55	;	;	:
cord-259603-bh198xgl	15	56	Lauber	Lauber	NNP
cord-259603-bh198xgl	15	57	et	et	NNP
cord-259603-bh198xgl	15	58	al	al	NNP
cord-259603-bh198xgl	15	59	.	.	NNP
cord-259603-bh198xgl	15	60	,	,	,
cord-259603-bh198xgl	15	61	2012	2012	CD
cord-259603-bh198xgl	15	62	)	)	-RRB-
cord-259603-bh198xgl	15	63	.	.	.
cord-259603-bh198xgl	16	1	In	in	IN
cord-259603-bh198xgl	16	2	addition	addition	NN
cord-259603-bh198xgl	16	3	to	to	IN
cord-259603-bh198xgl	16	4	including	include	VBG
cord-259603-bh198xgl	16	5	various	various	JJ
cord-259603-bh198xgl	16	6	highly	highly	RB
cord-259603-bh198xgl	16	7	pathogenic	pathogenic	JJ
cord-259603-bh198xgl	16	8	CoVs	cov	NNS
cord-259603-bh198xgl	16	9	of	of	IN
cord-259603-bh198xgl	16	10	livestock	livestock	NN
cord-259603-bh198xgl	16	11	(	(	-LRB-
cord-259603-bh198xgl	16	12	Saif	Saif	NNP
cord-259603-bh198xgl	16	13	,	,	,
cord-259603-bh198xgl	16	14	2004	2004	CD
cord-259603-bh198xgl	16	15	)	)	-RRB-
cord-259603-bh198xgl	16	16	and	and	CC
cord-259603-bh198xgl	16	17	four	four	CD
cord-259603-bh198xgl	16	18	"	"	``
cord-259603-bh198xgl	16	19	established	establish	VBN
cord-259603-bh198xgl	16	20	"	"	''
cord-259603-bh198xgl	16	21	human	human	JJ
cord-259603-bh198xgl	16	22	CoVs	CoVs	NNP
cord-259603-bh198xgl	16	23	causing	cause	VBG
cord-259603-bh198xgl	16	24	a	a	DT
cord-259603-bh198xgl	16	25	large	large	JJ
cord-259603-bh198xgl	16	26	number	number	NN
cord-259603-bh198xgl	16	27	of	of	IN
cord-259603-bh198xgl	16	28	common	common	JJ
cord-259603-bh198xgl	16	29	colds	cold	NNS
cord-259603-bh198xgl	16	30	(	(	-LRB-
cord-259603-bh198xgl	16	31	Pyrc	Pyrc	NNP
cord-259603-bh198xgl	16	32	et	et	NNP
cord-259603-bh198xgl	16	33	al	al	NNP
cord-259603-bh198xgl	16	34	.	.	NNP
cord-259603-bh198xgl	16	35	,	,	,
cord-259603-bh198xgl	16	36	2007	2007	CD
cord-259603-bh198xgl	16	37	)	)	-RRB-
cord-259603-bh198xgl	16	38	,	,	,
cord-259603-bh198xgl	16	39	CoVs	CoVs	NNP
cord-259603-bh198xgl	16	40	have	have	VBP
cord-259603-bh198xgl	16	41	attracted	attract	VBN
cord-259603-bh198xgl	16	42	abundant	abundant	JJ
cord-259603-bh198xgl	16	43	attention	attention	NN
cord-259603-bh198xgl	16	44	due	due	IN
cord-259603-bh198xgl	16	45	to	to	IN
cord-259603-bh198xgl	16	46	their	-PRON-	PRP$
cord-259603-bh198xgl	16	47	potential	potential	NN
cord-259603-bh198xgl	16	48	to	to	TO
cord-259603-bh198xgl	16	49	cause	cause	VB
cord-259603-bh198xgl	16	50	lethal	lethal	JJ
cord-259603-bh198xgl	16	51	zoonotic	zoonotic	JJ
cord-259603-bh198xgl	16	52	infections	infection	NNS
cord-259603-bh198xgl	16	53	(	(	-LRB-
cord-259603-bh198xgl	16	54	Graham	Graham	NNP
cord-259603-bh198xgl	16	55	et	et	NNP
cord-259603-bh198xgl	16	56	al	al	NNP
cord-259603-bh198xgl	16	57	.	.	NNP
cord-259603-bh198xgl	16	58	,	,	,
cord-259603-bh198xgl	16	59	2013	2013	CD
cord-259603-bh198xgl	16	60	)	)	-RRB-
cord-259603-bh198xgl	16	61	.	.	.
cord-259603-bh198xgl	17	1	This	this	DT
cord-259603-bh198xgl	17	2	was	be	VBD
cord-259603-bh198xgl	17	3	exemplified	exemplify	VBN
cord-259603-bh198xgl	17	4	by	by	IN
cord-259603-bh198xgl	17	5	the	the	DT
cord-259603-bh198xgl	17	6	2003	2003	CD
cord-259603-bh198xgl	17	7	outbreak	outbreak	NN
cord-259603-bh198xgl	17	8	of	of	IN
cord-259603-bh198xgl	17	9	severe	severe	JJ
cord-259603-bh198xgl	17	10	acute	acute	JJ
cord-259603-bh198xgl	17	11	respiratory	respiratory	JJ
cord-259603-bh198xgl	17	12	syndrome	syndrome	NN
cord-259603-bh198xgl	17	13	-	-	HYPH
cord-259603-bh198xgl	17	14	coronavirus	coronavirus	NN
cord-259603-bh198xgl	17	15	(	(	-LRB-
cord-259603-bh198xgl	17	16	SARS	SARS	NNP
cord-259603-bh198xgl	17	17	-	-	HYPH
cord-259603-bh198xgl	17	18	CoV	CoV	NNP
cord-259603-bh198xgl	17	19	)	)	-RRB-
cord-259603-bh198xgl	17	20	in	in	IN
cord-259603-bh198xgl	17	21	Southeast	Southeast	NNP
cord-259603-bh198xgl	17	22	Asia	Asia	NNP
cord-259603-bh198xgl	17	23	and	and	CC
cord-259603-bh198xgl	17	24	the	the	DT
cord-259603-bh198xgl	17	25	ongoing	ongoing	JJ
cord-259603-bh198xgl	17	26	transmission	transmission	NN
cord-259603-bh198xgl	17	27	-	-	:
cord-259603-bh198xgl	17	28	since	since	IN
cord-259603-bh198xgl	17	29	2012-of	2012-of	CD
cord-259603-bh198xgl	17	30	the	the	DT
cord-259603-bh198xgl	17	31	Middle	Middle	NNP
cord-259603-bh198xgl	17	32	East	East	NNP
cord-259603-bh198xgl	17	33	respiratory	respiratory	JJ
cord-259603-bh198xgl	17	34	syndromecoronavirus	syndromecoronavirus	NN
cord-259603-bh198xgl	17	35	(	(	-LRB-
cord-259603-bh198xgl	17	36	MERS	MERS	NNP
cord-259603-bh198xgl	17	37	-	-	HYPH
cord-259603-bh198xgl	17	38	CoV	CoV	NNP
cord-259603-bh198xgl	17	39	)	)	-RRB-
cord-259603-bh198xgl	17	40	,	,	,
cord-259603-bh198xgl	17	41	which	which	WDT
cord-259603-bh198xgl	17	42	causes	cause	VBZ
cord-259603-bh198xgl	17	43	$	$	$
cord-259603-bh198xgl	17	44	35	35	CD
cord-259603-bh198xgl	17	45	%	%	NN
cord-259603-bh198xgl	17	46	mortality	mortality	NN
cord-259603-bh198xgl	17	47	among	among	IN
cord-259603-bh198xgl	17	48	patients	patient	NNS
cord-259603-bh198xgl	17	49	seeking	seek	VBG
cord-259603-bh198xgl	17	50	medical	medical	JJ
cord-259603-bh198xgl	17	51	attention	attention	NN
cord-259603-bh198xgl	17	52	.	.	.
cord-259603-bh198xgl	18	1	Both	both	CC
cord-259603-bh198xgl	18	2	these	these	DT
cord-259603-bh198xgl	18	3	viruses	virus	NNS
cord-259603-bh198xgl	18	4	are	be	VBP
cord-259603-bh198xgl	18	5	closely	closely	RB
cord-259603-bh198xgl	18	6	related	relate	VBN
cord-259603-bh198xgl	18	7	to	to	IN
cord-259603-bh198xgl	18	8	CoVs	CoVs	NNP
cord-259603-bh198xgl	18	9	that	that	WDT
cord-259603-bh198xgl	18	10	are	be	VBP
cord-259603-bh198xgl	18	11	circulating	circulate	VBG
cord-259603-bh198xgl	18	12	in	in	IN
cord-259603-bh198xgl	18	13	bats	bat	NNS
cord-259603-bh198xgl	18	14	(	(	-LRB-
cord-259603-bh198xgl	18	15	Ge	Ge	NNP
cord-259603-bh198xgl	18	16	et	et	NNP
cord-259603-bh198xgl	18	17	al	al	NNP
cord-259603-bh198xgl	18	18	.	.	NNP
cord-259603-bh198xgl	18	19	,	,	,
cord-259603-bh198xgl	18	20	2013	2013	CD
cord-259603-bh198xgl	18	21	;	;	:
cord-259603-bh198xgl	18	22	Menachery	Menachery	NNP
cord-259603-bh198xgl	18	23	et	et	NNP
cord-259603-bh198xgl	18	24	al	al	NNP
cord-259603-bh198xgl	18	25	.	.	NNP
cord-259603-bh198xgl	18	26	,	,	,
cord-259603-bh198xgl	18	27	2015	2015	CD
cord-259603-bh198xgl	18	28	)	)	-RRB-
cord-259603-bh198xgl	18	29	and	and	CC
cord-259603-bh198xgl	18	30	other	other	JJ
cord-259603-bh198xgl	18	31	potential	potential	JJ
cord-259603-bh198xgl	18	32	reservoir	reservoir	NN
cord-259603-bh198xgl	18	33	species	specie	NNS
cord-259603-bh198xgl	18	34	.	.	.
cord-259603-bh198xgl	19	1	They	-PRON-	PRP
cord-259603-bh198xgl	19	2	may	may	MD
cord-259603-bh198xgl	19	3	be	be	VB
cord-259603-bh198xgl	19	4	transmitted	transmit	VBN
cord-259603-bh198xgl	19	5	to	to	IN
cord-259603-bh198xgl	19	6	humans	human	NNS
cord-259603-bh198xgl	19	7	either	either	CC
cord-259603-bh198xgl	19	8	directly	directly	RB
cord-259603-bh198xgl	19	9	or	or	CC
cord-259603-bh198xgl	19	10	through	through	IN
cord-259603-bh198xgl	19	11	intermediate	intermediate	JJ
cord-259603-bh198xgl	19	12	hosts	host	NNS
cord-259603-bh198xgl	19	13	,	,	,
cord-259603-bh198xgl	19	14	like	like	IN
cord-259603-bh198xgl	19	15	civet	civet	NN
cord-259603-bh198xgl	19	16	cats	cat	NNS
cord-259603-bh198xgl	19	17	for	for	IN
cord-259603-bh198xgl	19	18	SARS	SARS	NNP
cord-259603-bh198xgl	19	19	-	-	HYPH
cord-259603-bh198xgl	19	20	CoV	CoV	NNP
cord-259603-bh198xgl	19	21	(	(	-LRB-
cord-259603-bh198xgl	19	22	Song	Song	NNP
cord-259603-bh198xgl	19	23	et	et	FW
cord-259603-bh198xgl	19	24	al	al	NNP
cord-259603-bh198xgl	19	25	.	.	NNP
cord-259603-bh198xgl	19	26	,	,	,
cord-259603-bh198xgl	19	27	2005	2005	CD
cord-259603-bh198xgl	19	28	)	)	-RRB-
cord-259603-bh198xgl	19	29	and	and	CC
cord-259603-bh198xgl	19	30	dromedary	dromedary	NN
cord-259603-bh198xgl	19	31	camels	camel	NNS
cord-259603-bh198xgl	19	32	for	for	IN
cord-259603-bh198xgl	19	33	MERS	MERS	NNP
cord-259603-bh198xgl	19	34	-	-	HYPH
cord-259603-bh198xgl	19	35	CoV	CoV	NNP
cord-259603-bh198xgl	20	1	(	(	-LRB-
cord-259603-bh198xgl	20	2	Reusken	Reusken	NNP
cord-259603-bh198xgl	20	3	et	et	FW
cord-259603-bh198xgl	20	4	al	al	NNP
cord-259603-bh198xgl	20	5	.	.	NNP
cord-259603-bh198xgl	20	6	,	,	,
cord-259603-bh198xgl	20	7	2013	2013	CD
cord-259603-bh198xgl	20	8	)	)	-RRB-
cord-259603-bh198xgl	20	9	.	.	.
cord-259603-bh198xgl	21	1	Formally	formally	RB
cord-259603-bh198xgl	21	2	,	,	,
cord-259603-bh198xgl	21	3	the	the	DT
cord-259603-bh198xgl	21	4	family	family	NN
cord-259603-bh198xgl	21	5	Coronaviridae	Coronaviridae	NNP
cord-259603-bh198xgl	21	6	now	now	RB
cord-259603-bh198xgl	21	7	includes	include	VBZ
cord-259603-bh198xgl	21	8	about	about	IN
cord-259603-bh198xgl	21	9	30	30	CD
cord-259603-bh198xgl	21	10	species	specie	NNS
cord-259603-bh198xgl	21	11	,	,	,
cord-259603-bh198xgl	21	12	divided	divide	VBN
cord-259603-bh198xgl	21	13	into	into	IN
cord-259603-bh198xgl	21	14	the	the	DT
cord-259603-bh198xgl	21	15	subfamilies	subfamily	NNS
cord-259603-bh198xgl	22	1	Torovirinae	Torovirinae	NNP
cord-259603-bh198xgl	22	2	and	and	CC
cord-259603-bh198xgl	22	3	Coronavirinae	Coronavirinae	NNP
cord-259603-bh198xgl	22	4	,	,	,
cord-259603-bh198xgl	22	5	the	the	DT
cord-259603-bh198xgl	22	6	latter	latter	JJ
cord-259603-bh198xgl	22	7	being	be	VBG
cord-259603-bh198xgl	22	8	further	further	RB
cord-259603-bh198xgl	22	9	subdivided	subdivide	VBN
cord-259603-bh198xgl	22	10	in	in	IN
cord-259603-bh198xgl	22	11	the	the	DT
cord-259603-bh198xgl	22	12	genera	genera	NNP
cord-259603-bh198xgl	22	13	Alpha-	Alpha-	NNP
cord-259603-bh198xgl	22	14	,	,	,
cord-259603-bh198xgl	22	15	Beta-	Beta-	NNP
cord-259603-bh198xgl	22	16	,	,	,
cord-259603-bh198xgl	22	17	Gamma-	Gamma-	NNP
cord-259603-bh198xgl	22	18	,	,	,
cord-259603-bh198xgl	22	19	and	and	CC
cord-259603-bh198xgl	22	20	Deltacoronavirus	Deltacoronavirus	NNP
cord-259603-bh198xgl	22	21	.	.	.
cord-259603-bh198xgl	23	1	SARS	SARS	NNP
cord-259603-bh198xgl	23	2	-	-	HYPH
cord-259603-bh198xgl	23	3	CoV	CoV	NNP
cord-259603-bh198xgl	23	4	and	and	CC
cord-259603-bh198xgl	23	5	MERS	MERS	NNP
cord-259603-bh198xgl	23	6	-	-	HYPH
cord-259603-bh198xgl	23	7	CoV	CoV	NNP
cord-259603-bh198xgl	23	8	are	be	VBP
cord-259603-bh198xgl	23	9	betacoronaviruses	betacoronaviruse	NNS
cord-259603-bh198xgl	23	10	,	,	,
cord-259603-bh198xgl	23	11	and	and	CC
cord-259603-bh198xgl	23	12	the	the	DT
cord-259603-bh198xgl	23	13	same	same	JJ
cord-259603-bh198xgl	23	14	holds	hold	VBZ
cord-259603-bh198xgl	23	15	true	true	JJ
cord-259603-bh198xgl	23	16	for	for	IN
cord-259603-bh198xgl	23	17	one	one	CD
cord-259603-bh198xgl	23	18	of	of	IN
cord-259603-bh198xgl	23	19	the	the	DT
cord-259603-bh198xgl	23	20	best	well	RBS
cord-259603-bh198xgl	23	21	-	-	HYPH
cord-259603-bh198xgl	23	22	characterized	characterize	VBN
cord-259603-bh198xgl	23	23	animal	animal	NN
cord-259603-bh198xgl	23	24	CoV	cov	NN
cord-259603-bh198xgl	23	25	models	model	NNS
cord-259603-bh198xgl	23	26	,	,	,
cord-259603-bh198xgl	23	27	murine	murine	JJ
cord-259603-bh198xgl	23	28	hepatitis	hepatitis	NN
cord-259603-bh198xgl	23	29	virus	virus	NN
cord-259603-bh198xgl	23	30	(	(	-LRB-
cord-259603-bh198xgl	23	31	MHV	MHV	NNP
cord-259603-bh198xgl	23	32	)	)	-RRB-
cord-259603-bh198xgl	23	33	.	.	.
cord-259603-bh198xgl	24	1	This	this	DT
cord-259603-bh198xgl	24	2	explains	explain	VBZ
cord-259603-bh198xgl	24	3	why	why	WRB
cord-259603-bh198xgl	24	4	the	the	DT
cord-259603-bh198xgl	24	5	bulk	bulk	NN
cord-259603-bh198xgl	24	6	of	of	IN
cord-259603-bh198xgl	24	7	our	-PRON-	PRP$
cord-259603-bh198xgl	24	8	current	current	JJ
cord-259603-bh198xgl	24	9	knowledge	knowledge	NN
cord-259603-bh198xgl	24	10	of	of	IN
cord-259603-bh198xgl	24	11	CoV	cov	NN
cord-259603-bh198xgl	24	12	molecular	molecular	JJ
cord-259603-bh198xgl	24	13	biology	biology	NN
cord-259603-bh198xgl	24	14	is	be	VBZ
cord-259603-bh198xgl	24	15	betacoronavirus	betacoronavirus	NNP
cord-259603-bh198xgl	24	16	based	base	VBN
cord-259603-bh198xgl	24	17	,	,	,
cord-259603-bh198xgl	24	18	even	even	RB
cord-259603-bh198xgl	24	19	more	more	RBR
cord-259603-bh198xgl	24	20	so	so	RB
cord-259603-bh198xgl	24	21	for	for	IN
cord-259603-bh198xgl	24	22	the	the	DT
cord-259603-bh198xgl	24	23	replicative	replicative	JJ
cord-259603-bh198xgl	24	24	proteins	protein	NNS
cord-259603-bh198xgl	24	25	that	that	WDT
cord-259603-bh198xgl	24	26	are	be	VBP
cord-259603-bh198xgl	24	27	the	the	DT
cord-259603-bh198xgl	24	28	central	central	JJ
cord-259603-bh198xgl	24	29	theme	theme	NN
cord-259603-bh198xgl	24	30	of	of	IN
cord-259603-bh198xgl	24	31	this	this	DT
cord-259603-bh198xgl	24	32	review	review	NN
cord-259603-bh198xgl	24	33	,	,	,
cord-259603-bh198xgl	24	34	which	which	WDT
cord-259603-bh198xgl	24	35	will	will	MD
cord-259603-bh198xgl	24	36	mainly	mainly	RB
cord-259603-bh198xgl	24	37	summarize	summarize	VB
cord-259603-bh198xgl	24	38	data	datum	NNS
cord-259603-bh198xgl	24	39	obtained	obtain	VBD
cord-259603-bh198xgl	24	40	studying	study	VBG
cord-259603-bh198xgl	24	41	SARS	SARS	NNP
cord-259603-bh198xgl	24	42	-	-	HYPH
cord-259603-bh198xgl	24	43	CoV	cov	NN
cord-259603-bh198xgl	24	44	proteins	protein	NNS
cord-259603-bh198xgl	24	45	.	.	.
cord-259603-bh198xgl	25	1	Despite	despite	IN
cord-259603-bh198xgl	25	2	their	-PRON-	PRP$
cord-259603-bh198xgl	25	3	unification	unification	NN
cord-259603-bh198xgl	25	4	in	in	IN
cord-259603-bh198xgl	25	5	the	the	DT
cord-259603-bh198xgl	25	6	same	same	JJ
cord-259603-bh198xgl	25	7	virus	virus	NN
cord-259603-bh198xgl	25	8	order	order	NN
cord-259603-bh198xgl	25	9	,	,	,
cord-259603-bh198xgl	25	10	nidoviruses	nidoviruses	NNP
cord-259603-bh198xgl	25	11	cover	cover	VBP
cord-259603-bh198xgl	25	12	an	an	DT
cord-259603-bh198xgl	25	13	unusually	unusually	RB
cord-259603-bh198xgl	25	14	broad	broad	JJ
cord-259603-bh198xgl	25	15	range	range	NN
cord-259603-bh198xgl	25	16	of	of	IN
cord-259603-bh198xgl	25	17	genome	genome	NN
cord-259603-bh198xgl	25	18	sizes	size	NNS
cord-259603-bh198xgl	25	19	,	,	,
cord-259603-bh198xgl	25	20	ranging	range	VBG
cord-259603-bh198xgl	25	21	from	from	IN
cord-259603-bh198xgl	25	22	$	$	$
cord-259603-bh198xgl	25	23	13	13	CD
cord-259603-bh198xgl	25	24	-	-	SYM
cord-259603-bh198xgl	25	25	16	16	CD
cord-259603-bh198xgl	25	26	kilobases	kilobase	NNS
cord-259603-bh198xgl	25	27	(	(	-LRB-
cord-259603-bh198xgl	25	28	kb	kb	NNP
cord-259603-bh198xgl	25	29	)	)	-RRB-
cord-259603-bh198xgl	25	30	for	for	IN
cord-259603-bh198xgl	25	31	arteriviruses	arteriviruse	NNS
cord-259603-bh198xgl	25	32	,	,	,
cord-259603-bh198xgl	25	33	via	via	IN
cord-259603-bh198xgl	25	34	$	$	$
cord-259603-bh198xgl	25	35	20	20	CD
cord-259603-bh198xgl	25	36	kb	kb	NNS
cord-259603-bh198xgl	25	37	for	for	IN
cord-259603-bh198xgl	25	38	mesoniviruses	mesoniviruse	NNS
cord-259603-bh198xgl	25	39	,	,	,
cord-259603-bh198xgl	25	40	to	to	IN
cord-259603-bh198xgl	25	41	$	$	$
cord-259603-bh198xgl	25	42	26	26	CD
cord-259603-bh198xgl	25	43	-	-	SYM
cord-259603-bh198xgl	25	44	32	32	CD
cord-259603-bh198xgl	25	45	kb	kb	NNS
cord-259603-bh198xgl	25	46	for	for	IN
cord-259603-bh198xgl	25	47	CoVs	CoVs	NNP
cord-259603-bh198xgl	25	48	(	(	-LRB-
cord-259603-bh198xgl	25	49	Nga	Nga	NNP
cord-259603-bh198xgl	25	50	et	et	NNP
cord-259603-bh198xgl	25	51	al	al	NNP
cord-259603-bh198xgl	25	52	.	.	NNP
cord-259603-bh198xgl	25	53	,	,	,
cord-259603-bh198xgl	25	54	2011	2011	CD
cord-259603-bh198xgl	25	55	)	)	-RRB-
cord-259603-bh198xgl	25	56	.	.	.
cord-259603-bh198xgl	26	1	Together	together	RB
cord-259603-bh198xgl	26	2	with	with	IN
cord-259603-bh198xgl	26	3	the	the	DT
cord-259603-bh198xgl	26	4	genomes	genome	NNS
cord-259603-bh198xgl	26	5	of	of	IN
cord-259603-bh198xgl	26	6	roniviruses	roniviruse	NNS
cord-259603-bh198xgl	26	7	,	,	,
cord-259603-bh198xgl	26	8	which	which	WDT
cord-259603-bh198xgl	26	9	infect	infect	VBP
cord-259603-bh198xgl	26	10	invertebrate	invertebrate	JJ
cord-259603-bh198xgl	26	11	hosts	host	NNS
cord-259603-bh198xgl	26	12	,	,	,
cord-259603-bh198xgl	26	13	CoV	cov	NN
cord-259603-bh198xgl	26	14	genomes	genome	NNS
cord-259603-bh198xgl	26	15	are	be	VBP
cord-259603-bh198xgl	26	16	the	the	DT
cord-259603-bh198xgl	26	17	largest	large	JJS
cord-259603-bh198xgl	26	18	RNA	RNA	NNP
cord-259603-bh198xgl	26	19	genomes	genome	NNS
cord-259603-bh198xgl	26	20	known	know	VBN
cord-259603-bh198xgl	26	21	to	to	IN
cord-259603-bh198xgl	26	22	date	date	NN
cord-259603-bh198xgl	26	23	.	.	.
cord-259603-bh198xgl	27	1	The	the	DT
cord-259603-bh198xgl	27	2	common	common	JJ
cord-259603-bh198xgl	27	3	ancestry	ancestry	NN
cord-259603-bh198xgl	27	4	of	of	IN
cord-259603-bh198xgl	27	5	these	these	DT
cord-259603-bh198xgl	27	6	extremely	extremely	RB
cord-259603-bh198xgl	27	7	diverse	diverse	JJ
cord-259603-bh198xgl	27	8	virus	virus	NN
cord-259603-bh198xgl	27	9	lineages	lineage	NNS
cord-259603-bh198xgl	27	10	was	be	VBD
cord-259603-bh198xgl	27	11	inferred	infer	VBN
cord-259603-bh198xgl	27	12	from	from	IN
cord-259603-bh198xgl	27	13	their	-PRON-	PRP$
cord-259603-bh198xgl	27	14	polycistronic	polycistronic	NNP
cord-259603-bh198xgl	27	15	genome	genome	NN
cord-259603-bh198xgl	27	16	structure	structure	NN
cord-259603-bh198xgl	27	17	,	,	,
cord-259603-bh198xgl	27	18	the	the	DT
cord-259603-bh198xgl	27	19	common	common	JJ
cord-259603-bh198xgl	27	20	principles	principle	NNS
cord-259603-bh198xgl	27	21	underlying	underlie	VBG
cord-259603-bh198xgl	27	22	the	the	DT
cord-259603-bh198xgl	27	23	expression	expression	NN
cord-259603-bh198xgl	27	24	of	of	IN
cord-259603-bh198xgl	27	25	these	these	DT
cord-259603-bh198xgl	27	26	genomes	genome	NNS
cord-259603-bh198xgl	27	27	,	,	,
cord-259603-bh198xgl	27	28	and	and	CC
cord-259603-bh198xgl	27	29	-	-	:
cord-259603-bh198xgl	27	30	most	most	RBS
cord-259603-bh198xgl	27	31	importantly	importantly	RB
cord-259603-bh198xgl	27	32	-	-	:
cord-259603-bh198xgl	27	33	the	the	DT
cord-259603-bh198xgl	27	34	conservation	conservation	NN
cord-259603-bh198xgl	27	35	of	of	IN
cord-259603-bh198xgl	27	36	an	an	DT
cord-259603-bh198xgl	27	37	array	array	NN
cord-259603-bh198xgl	27	38	of	of	IN
cord-259603-bh198xgl	27	39	"	"	``
cord-259603-bh198xgl	27	40	core	core	JJ
cord-259603-bh198xgl	27	41	replicase	replicase	NN
cord-259603-bh198xgl	27	42	domains	domain	NNS
cord-259603-bh198xgl	27	43	,	,	,
cord-259603-bh198xgl	27	44	"	"	''
cord-259603-bh198xgl	27	45	including	include	VBG
cord-259603-bh198xgl	27	46	key	key	JJ
cord-259603-bh198xgl	27	47	enzymes	enzyme	NNS
cord-259603-bh198xgl	27	48	required	require	VBN
cord-259603-bh198xgl	27	49	for	for	IN
cord-259603-bh198xgl	27	50	RNA	RNA	NNP
cord-259603-bh198xgl	27	51	synthesis	synthesis	NN
cord-259603-bh198xgl	27	52	.	.	.
cord-259603-bh198xgl	28	1	While	while	IN
cord-259603-bh198xgl	28	2	retaining	retain	VBG
cord-259603-bh198xgl	28	3	this	this	DT
cord-259603-bh198xgl	28	4	conserved	conserved	JJ
cord-259603-bh198xgl	28	5	genomic	genomic	JJ
cord-259603-bh198xgl	28	6	and	and	CC
cord-259603-bh198xgl	28	7	proteomic	proteomic	JJ
cord-259603-bh198xgl	28	8	blueprint	blueprint	NN
cord-259603-bh198xgl	28	9	,	,	,
cord-259603-bh198xgl	28	10	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	28	11	genomes	genome	NNS
cord-259603-bh198xgl	28	12	are	be	VBP
cord-259603-bh198xgl	28	13	thought	think	VBN
cord-259603-bh198xgl	28	14	to	to	TO
cord-259603-bh198xgl	28	15	have	have	VB
cord-259603-bh198xgl	28	16	expanded	expand	VBN
cord-259603-bh198xgl	28	17	gradually	gradually	RB
cord-259603-bh198xgl	28	18	by	by	IN
cord-259603-bh198xgl	28	19	gene	gene	NN
cord-259603-bh198xgl	28	20	duplication	duplication	NN
cord-259603-bh198xgl	28	21	and	and	CC
cord-259603-bh198xgl	28	22	acquisition	acquisition	NN
cord-259603-bh198xgl	28	23	of	of	IN
cord-259603-bh198xgl	28	24	novel	novel	JJ
cord-259603-bh198xgl	28	25	genes	gene	NNS
cord-259603-bh198xgl	28	26	(	(	-LRB-
cord-259603-bh198xgl	28	27	Lauber	Lauber	NNP
cord-259603-bh198xgl	28	28	et	et	FW
cord-259603-bh198xgl	28	29	al	al	NNP
cord-259603-bh198xgl	28	30	.	.	NNP
cord-259603-bh198xgl	28	31	,	,	,
cord-259603-bh198xgl	28	32	2013	2013	CD
cord-259603-bh198xgl	28	33	)	)	-RRB-
cord-259603-bh198xgl	28	34	,	,	,
cord-259603-bh198xgl	28	35	most	most	RBS
cord-259603-bh198xgl	28	36	likely	likely	JJ
cord-259603-bh198xgl	28	37	by	by	IN
cord-259603-bh198xgl	28	38	RNA	RNA	NNP
cord-259603-bh198xgl	28	39	recombination	recombination	NN
cord-259603-bh198xgl	28	40	.	.	.
cord-259603-bh198xgl	29	1	In	in	IN
cord-259603-bh198xgl	29	2	addition	addition	NN
cord-259603-bh198xgl	29	3	to	to	IN
cord-259603-bh198xgl	29	4	the	the	DT
cord-259603-bh198xgl	29	5	high	high	JJ
cord-259603-bh198xgl	29	6	mutation	mutation	NN
cord-259603-bh198xgl	29	7	rate	rate	NN
cord-259603-bh198xgl	29	8	that	that	WDT
cord-259603-bh198xgl	29	9	characterizes	characterize	VBZ
cord-259603-bh198xgl	29	10	all	all	DT
cord-259603-bh198xgl	29	11	RNA	RNA	NNP
cord-259603-bh198xgl	29	12	viruses	virus	NNS
cord-259603-bh198xgl	29	13	,	,	,
cord-259603-bh198xgl	29	14	these	these	DT
cord-259603-bh198xgl	29	15	genomic	genomic	JJ
cord-259603-bh198xgl	29	16	innovations	innovation	NNS
cord-259603-bh198xgl	29	17	appear	appear	VBP
cord-259603-bh198xgl	29	18	to	to	TO
cord-259603-bh198xgl	29	19	have	have	VB
cord-259603-bh198xgl	29	20	enabled	enable	VBN
cord-259603-bh198xgl	29	21	nidoviruses	nidoviruse	NNS
cord-259603-bh198xgl	29	22	to	to	TO
cord-259603-bh198xgl	29	23	explore	explore	VB
cord-259603-bh198xgl	29	24	an	an	DT
cord-259603-bh198xgl	29	25	unprecedented	unprecedented	JJ
cord-259603-bh198xgl	29	26	evolutionary	evolutionary	JJ
cord-259603-bh198xgl	29	27	space	space	NN
cord-259603-bh198xgl	29	28	and	and	CC
cord-259603-bh198xgl	29	29	adapt	adapt	VB
cord-259603-bh198xgl	29	30	to	to	IN
cord-259603-bh198xgl	29	31	a	a	DT
cord-259603-bh198xgl	29	32	wide	wide	JJ
cord-259603-bh198xgl	29	33	variety	variety	NN
cord-259603-bh198xgl	29	34	of	of	IN
cord-259603-bh198xgl	29	35	host	host	NN
cord-259603-bh198xgl	29	36	organisms	organism	NNS
cord-259603-bh198xgl	29	37	,	,	,
cord-259603-bh198xgl	29	38	including	include	VBG
cord-259603-bh198xgl	29	39	mammals	mammal	NNS
cord-259603-bh198xgl	29	40	,	,	,
cord-259603-bh198xgl	29	41	birds	bird	NNS
cord-259603-bh198xgl	29	42	,	,	,
cord-259603-bh198xgl	29	43	reptiles	reptile	NNS
cord-259603-bh198xgl	29	44	,	,	,
cord-259603-bh198xgl	29	45	fish	fish	NN
cord-259603-bh198xgl	29	46	,	,	,
cord-259603-bh198xgl	29	47	crustaceans	crustacean	NNS
cord-259603-bh198xgl	29	48	,	,	,
cord-259603-bh198xgl	29	49	and	and	CC
cord-259603-bh198xgl	29	50	insects	insect	NNS
cord-259603-bh198xgl	29	51	.	.	.
cord-259603-bh198xgl	30	1	Whereas	whereas	IN
cord-259603-bh198xgl	30	2	the	the	DT
cord-259603-bh198xgl	30	3	poor	poor	JJ
cord-259603-bh198xgl	30	4	replication	replication	NN
cord-259603-bh198xgl	30	5	fidelity	fidelity	NN
cord-259603-bh198xgl	30	6	generally	generally	RB
cord-259603-bh198xgl	30	7	restricts	restrict	VBZ
cord-259603-bh198xgl	30	8	RNA	RNA	NNP
cord-259603-bh198xgl	30	9	virus	virus	NN
cord-259603-bh198xgl	30	10	genome	genome	NN
cord-259603-bh198xgl	30	11	sizes	size	NNS
cord-259603-bh198xgl	30	12	,	,	,
cord-259603-bh198xgl	30	13	it	-PRON-	PRP
cord-259603-bh198xgl	30	14	has	have	VBZ
cord-259603-bh198xgl	30	15	been	be	VBN
cord-259603-bh198xgl	30	16	postulated	postulate	VBN
cord-259603-bh198xgl	30	17	that	that	IN
cord-259603-bh198xgl	30	18	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	30	19	genome	genome	NNP
cord-259603-bh198xgl	30	20	expansion	expansion	NN
cord-259603-bh198xgl	30	21	was	be	VBD
cord-259603-bh198xgl	30	22	enabled	enable	VBN
cord-259603-bh198xgl	30	23	by	by	IN
cord-259603-bh198xgl	30	24	the	the	DT
cord-259603-bh198xgl	30	25	acquisition	acquisition	NN
cord-259603-bh198xgl	30	26	of	of	IN
cord-259603-bh198xgl	30	27	specific	specific	JJ
cord-259603-bh198xgl	30	28	replicative	replicative	JJ
cord-259603-bh198xgl	30	29	functions	function	NNS
cord-259603-bh198xgl	30	30	that	that	WDT
cord-259603-bh198xgl	30	31	counter	counter	VBP
cord-259603-bh198xgl	30	32	the	the	DT
cord-259603-bh198xgl	30	33	error	error	NN
cord-259603-bh198xgl	30	34	rate	rate	NN
cord-259603-bh198xgl	30	35	of	of	IN
cord-259603-bh198xgl	30	36	the	the	DT
cord-259603-bh198xgl	30	37	RNA	RNA	NNP
cord-259603-bh198xgl	30	38	polymerase	polymerase	NN
cord-259603-bh198xgl	31	1	(	(	-LRB-
cord-259603-bh198xgl	31	2	Deng	Deng	NNP
cord-259603-bh198xgl	31	3	et	et	FW
cord-259603-bh198xgl	31	4	al	al	NNP
cord-259603-bh198xgl	31	5	.	.	.
cord-259603-bh198xgl	32	1	,	,	,
cord-259603-bh198xgl	32	2	2014	2014	CD
cord-259603-bh198xgl	32	3	;	;	:
cord-259603-bh198xgl	32	4	Eckerle	Eckerle	NNP
cord-259603-bh198xgl	32	5	et	et	NNP
cord-259603-bh198xgl	32	6	al	al	NNP
cord-259603-bh198xgl	32	7	.	.	NNP
cord-259603-bh198xgl	32	8	,	,	,
cord-259603-bh198xgl	32	9	2010	2010	CD
cord-259603-bh198xgl	32	10	;	;	:
cord-259603-bh198xgl	32	11	Snijder	Snijder	NNP
cord-259603-bh198xgl	32	12	et	et	NNP
cord-259603-bh198xgl	32	13	al	al	NNP
cord-259603-bh198xgl	32	14	.	.	NNP
cord-259603-bh198xgl	32	15	,	,	,
cord-259603-bh198xgl	32	16	2003	2003	CD
cord-259603-bh198xgl	32	17	)	)	-RRB-
cord-259603-bh198xgl	33	1	(	(	-LRB-
cord-259603-bh198xgl	33	2	discussed	discuss	VBN
cord-259603-bh198xgl	33	3	in	in	IN
cord-259603-bh198xgl	33	4	more	more	JJR
cord-259603-bh198xgl	33	5	detail	detail	NN
cord-259603-bh198xgl	33	6	later	later	RB
cord-259603-bh198xgl	33	7	)	)	-RRB-
cord-259603-bh198xgl	33	8	.	.	.
cord-259603-bh198xgl	34	1	As	as	IN
cord-259603-bh198xgl	34	2	in	in	IN
cord-259603-bh198xgl	34	3	all	all	DT
cord-259603-bh198xgl	34	4	nidoviruses	nidoviruse	NNS
cord-259603-bh198xgl	34	5	,	,	,
cord-259603-bh198xgl	34	6	at	at	RB
cord-259603-bh198xgl	34	7	least	least	JJS
cord-259603-bh198xgl	34	8	two	two	CD
cord-259603-bh198xgl	34	9	-	-	HYPH
cord-259603-bh198xgl	34	10	thirds	third	NNS
cord-259603-bh198xgl	34	11	of	of	IN
cord-259603-bh198xgl	34	12	the	the	DT
cord-259603-bh198xgl	34	13	CoV	cov	NN
cord-259603-bh198xgl	34	14	genome	genome	NN
cord-259603-bh198xgl	34	15	capacity	capacity	NN
cord-259603-bh198xgl	34	16	is	be	VBZ
cord-259603-bh198xgl	34	17	occupied	occupy	VBN
cord-259603-bh198xgl	34	18	by	by	IN
cord-259603-bh198xgl	34	19	the	the	DT
cord-259603-bh198xgl	34	20	two	two	CD
cord-259603-bh198xgl	34	21	large	large	JJ
cord-259603-bh198xgl	34	22	open	open	JJ
cord-259603-bh198xgl	34	23	reading	reading	NN
cord-259603-bh198xgl	34	24	frames	frame	NNS
cord-259603-bh198xgl	34	25	(	(	-LRB-
cord-259603-bh198xgl	34	26	ORFs	ORFs	NNP
cord-259603-bh198xgl	34	27	)	)	-RRB-
cord-259603-bh198xgl	34	28	that	that	IN
cord-259603-bh198xgl	34	29	together	together	RB
cord-259603-bh198xgl	34	30	constitute	constitute	VBP
cord-259603-bh198xgl	34	31	the	the	DT
cord-259603-bh198xgl	34	32	replicase	replicase	NN
cord-259603-bh198xgl	34	33	gene	gene	NN
cord-259603-bh198xgl	34	34	,	,	,
cord-259603-bh198xgl	34	35	ORF1a	ORF1a	NNP
cord-259603-bh198xgl	34	36	and	and	CC
cord-259603-bh198xgl	34	37	ORF1b	ORF1b	NNP
cord-259603-bh198xgl	34	38	(	(	-LRB-
cord-259603-bh198xgl	34	39	Fig	Fig	NNP
cord-259603-bh198xgl	34	40	.	.	NNP
cord-259603-bh198xgl	34	41	1	1	CD
cord-259603-bh198xgl	34	42	)	)	-RRB-
cord-259603-bh198xgl	34	43	.	.	.
cord-259603-bh198xgl	35	1	These	these	DT
cord-259603-bh198xgl	35	2	ORFs	orf	NNS
cord-259603-bh198xgl	35	3	overlap	overlap	VBP
cord-259603-bh198xgl	35	4	by	by	IN
cord-259603-bh198xgl	35	5	a	a	DT
cord-259603-bh198xgl	35	6	few	few	JJ
cord-259603-bh198xgl	35	7	dozen	dozen	NN
cord-259603-bh198xgl	35	8	nucleotides	nucleotide	NNS
cord-259603-bh198xgl	35	9	and	and	CC
cord-259603-bh198xgl	35	10	are	be	VBP
cord-259603-bh198xgl	35	11	both	both	DT
cord-259603-bh198xgl	35	12	translated	translate	VBN
cord-259603-bh198xgl	35	13	from	from	IN
cord-259603-bh198xgl	35	14	the	the	DT
cord-259603-bh198xgl	35	15	viral	viral	JJ
cord-259603-bh198xgl	35	16	genome	genome	NN
cord-259603-bh198xgl	35	17	,	,	,
cord-259603-bh198xgl	35	18	with	with	IN
cord-259603-bh198xgl	35	19	expression	expression	NN
cord-259603-bh198xgl	35	20	of	of	IN
cord-259603-bh198xgl	35	21	ORF1b	ORF1b	NNP
cord-259603-bh198xgl	35	22	requiring	require	VBG
cord-259603-bh198xgl	35	23	a	a	DT
cord-259603-bh198xgl	35	24	-1	-1	NN
cord-259603-bh198xgl	35	25	ribosomal	ribosomal	JJ
cord-259603-bh198xgl	35	26	frameshift	frameshift	NN
cord-259603-bh198xgl	35	27	to	to	TO
cord-259603-bh198xgl	35	28	occur	occur	VB
cord-259603-bh198xgl	35	29	just	just	RB
cord-259603-bh198xgl	35	30	Fig	Fig	NNP
cord-259603-bh198xgl	35	31	.	.	.
cord-259603-bh198xgl	36	1	1	1	CD
cord-259603-bh198xgl	36	2	Outline	Outline	NNP
cord-259603-bh198xgl	36	3	of	of	IN
cord-259603-bh198xgl	36	4	the	the	DT
cord-259603-bh198xgl	36	5	CoV	CoV	NNP
cord-259603-bh198xgl	36	6	genome	genome	NNP
cord-259603-bh198xgl	36	7	organization	organization	NN
cord-259603-bh198xgl	36	8	and	and	CC
cord-259603-bh198xgl	36	9	expression	expression	NN
cord-259603-bh198xgl	36	10	strategy	strategy	NN
cord-259603-bh198xgl	36	11	,	,	,
cord-259603-bh198xgl	36	12	based	base	VBN
cord-259603-bh198xgl	36	13	on	on	IN
cord-259603-bh198xgl	36	14	SARS-	SARS-	NNP
cord-259603-bh198xgl	37	1	CoV.	CoV.	NNP
cord-259603-bh198xgl	38	1	The	the	DT
cord-259603-bh198xgl	38	2	top	top	JJ
cord-259603-bh198xgl	38	3	panel	panel	NN
cord-259603-bh198xgl	38	4	depicts	depict	VBZ
cord-259603-bh198xgl	38	5	the	the	DT
cord-259603-bh198xgl	38	6	SARS	SARS	NNP
cord-259603-bh198xgl	38	7	-	-	HYPH
cord-259603-bh198xgl	38	8	CoV	CoV	NNP
cord-259603-bh198xgl	38	9	genome	genome	NN
cord-259603-bh198xgl	38	10	,	,	,
cord-259603-bh198xgl	38	11	including	include	VBG
cord-259603-bh198xgl	38	12	various	various	JJ
cord-259603-bh198xgl	38	13	regulatory	regulatory	JJ
cord-259603-bh198xgl	38	14	RNA	RNA	NNP
cord-259603-bh198xgl	38	15	elements	element	NNS
cord-259603-bh198xgl	38	16	,	,	,
cord-259603-bh198xgl	38	17	and	and	CC
cord-259603-bh198xgl	38	18	the	the	DT
cord-259603-bh198xgl	38	19	5	5	CD
cord-259603-bh198xgl	38	20	0	0	CD
cord-259603-bh198xgl	38	21	-and	-and	SYM
cord-259603-bh198xgl	38	22	3	3	CD
cord-259603-bh198xgl	38	23	0	0	CD
cord-259603-bh198xgl	38	24	-coterminal	-coterminal	JJ
cord-259603-bh198xgl	38	25	nested	nested	JJ
cord-259603-bh198xgl	38	26	set	set	NN
cord-259603-bh198xgl	38	27	of	of	IN
cord-259603-bh198xgl	38	28	subgenomic	subgenomic	NNP
cord-259603-bh198xgl	38	29	mRNAs	mRNAs	NNPS
cord-259603-bh198xgl	38	30	used	use	VBD
cord-259603-bh198xgl	38	31	to	to	TO
cord-259603-bh198xgl	38	32	express	express	VB
cord-259603-bh198xgl	38	33	the	the	DT
cord-259603-bh198xgl	38	34	genes	gene	NNS
cord-259603-bh198xgl	38	35	downstream	downstream	RB
cord-259603-bh198xgl	38	36	of	of	IN
cord-259603-bh198xgl	38	37	the	the	DT
cord-259603-bh198xgl	38	38	replicase	replicase	NN
cord-259603-bh198xgl	38	39	gene	gene	NN
cord-259603-bh198xgl	38	40	.	.	.
cord-259603-bh198xgl	39	1	UTR	UTR	NNP
cord-259603-bh198xgl	39	2	,	,	,
cord-259603-bh198xgl	39	3	untranslated	untranslated	JJ
cord-259603-bh198xgl	39	4	region	region	NN
cord-259603-bh198xgl	39	5	;	;	:
cord-259603-bh198xgl	39	6	TRS	TRS	NNP
cord-259603-bh198xgl	39	7	,	,	,
cord-259603-bh198xgl	39	8	transcription	transcription	NN
cord-259603-bh198xgl	39	9	-	-	HYPH
cord-259603-bh198xgl	39	10	regulatory	regulatory	JJ
cord-259603-bh198xgl	39	11	sequence	sequence	NN
cord-259603-bh198xgl	39	12	.	.	.
cord-259603-bh198xgl	40	1	Below	below	IN
cord-259603-bh198xgl	40	2	the	the	DT
cord-259603-bh198xgl	40	3	RNAs	rna	NNS
cord-259603-bh198xgl	40	4	,	,	,
cord-259603-bh198xgl	40	5	the	the	DT
cord-259603-bh198xgl	40	6	14	14	CD
cord-259603-bh198xgl	40	7	open	open	JJ
cord-259603-bh198xgl	40	8	reading	reading	NN
cord-259603-bh198xgl	40	9	frames	frame	NNS
cord-259603-bh198xgl	40	10	in	in	IN
cord-259603-bh198xgl	40	11	the	the	DT
cord-259603-bh198xgl	40	12	genome	genome	NN
cord-259603-bh198xgl	40	13	are	be	VBP
cord-259603-bh198xgl	40	14	indicated	indicate	VBN
cord-259603-bh198xgl	40	15	,	,	,
cord-259603-bh198xgl	40	16	i.e.	i.e.	FW
cord-259603-bh198xgl	40	17	,	,	,
cord-259603-bh198xgl	40	18	the	the	DT
cord-259603-bh198xgl	40	19	replicase	replicase	NN
cord-259603-bh198xgl	40	20	ORFs	ORFs	NNP
cord-259603-bh198xgl	40	21	1a	1a	NN
cord-259603-bh198xgl	40	22	and	and	CC
cord-259603-bh198xgl	40	23	1b	1b	CD
cord-259603-bh198xgl	40	24	,	,	,
cord-259603-bh198xgl	40	25	the	the	DT
cord-259603-bh198xgl	40	26	four	four	CD
cord-259603-bh198xgl	40	27	common	common	JJ
cord-259603-bh198xgl	40	28	CoV	CoV	NNP
cord-259603-bh198xgl	40	29	structural	structural	JJ
cord-259603-bh198xgl	40	30	protein	protein	NN
cord-259603-bh198xgl	40	31	genes	gene	NNS
cord-259603-bh198xgl	40	32	(	(	-LRB-
cord-259603-bh198xgl	40	33	S	S	NNP
cord-259603-bh198xgl	40	34	,	,	,
cord-259603-bh198xgl	40	35	E	E	NNP
cord-259603-bh198xgl	40	36	,	,	,
cord-259603-bh198xgl	40	37	M	M	NNP
cord-259603-bh198xgl	40	38	,	,	,
cord-259603-bh198xgl	40	39	and	and	CC
cord-259603-bh198xgl	40	40	N	N	NNP
cord-259603-bh198xgl	40	41	)	)	-RRB-
cord-259603-bh198xgl	40	42	and	and	CC
cord-259603-bh198xgl	40	43	the	the	DT
cord-259603-bh198xgl	40	44	ORFs	orfs	NN
cord-259603-bh198xgl	40	45	encoding	encode	VBG
cord-259603-bh198xgl	40	46	"	"	''
cord-259603-bh198xgl	40	47	accessory	accessory	NN
cord-259603-bh198xgl	40	48	proteins	protein	NNS
cord-259603-bh198xgl	40	49	.	.	.
cord-259603-bh198xgl	40	50	"	"	''
cord-259603-bh198xgl	41	1	The	the	DT
cord-259603-bh198xgl	41	2	bottom	bottom	JJ
cord-259603-bh198xgl	41	3	panel	panel	NN
cord-259603-bh198xgl	41	4	explains	explain	VBZ
cord-259603-bh198xgl	41	5	the	the	DT
cord-259603-bh198xgl	41	6	organization	organization	NN
cord-259603-bh198xgl	41	7	and	and	CC
cord-259603-bh198xgl	41	8	proteolytic	proteolytic	JJ
cord-259603-bh198xgl	41	9	processing	processing	NN
cord-259603-bh198xgl	41	10	of	of	IN
cord-259603-bh198xgl	41	11	the	the	DT
cord-259603-bh198xgl	41	12	pp1a	pp1a	NNP
cord-259603-bh198xgl	41	13	and	and	CC
cord-259603-bh198xgl	41	14	pp1ab	pp1ab	NNP
cord-259603-bh198xgl	41	15	replicase	replicase	NN
cord-259603-bh198xgl	41	16	polyproteins	polyprotein	NNS
cord-259603-bh198xgl	41	17	,	,	,
cord-259603-bh198xgl	41	18	the	the	DT
cord-259603-bh198xgl	41	19	latter	latter	JJ
cord-259603-bh198xgl	41	20	being	be	VBG
cord-259603-bh198xgl	41	21	produced	produce	VBN
cord-259603-bh198xgl	41	22	by	by	IN
cord-259603-bh198xgl	41	23	-1	-1	CD
cord-259603-bh198xgl	41	24	ribosomal	ribosomal	JJ
cord-259603-bh198xgl	41	25	frameshifting	frameshifting	NN
cord-259603-bh198xgl	41	26	.	.	.
cord-259603-bh198xgl	42	1	The	the	DT
cord-259603-bh198xgl	42	2	nsp3	nsp3	NNS
cord-259603-bh198xgl	42	3	(	(	-LRB-
cord-259603-bh198xgl	42	4	PL	PL	NNP
cord-259603-bh198xgl	42	5	pro	pro	FW
cord-259603-bh198xgl	42	6	)	)	-RRB-
cord-259603-bh198xgl	42	7	and	and	CC
cord-259603-bh198xgl	42	8	nsp5	nsp5	NN
cord-259603-bh198xgl	42	9	(	(	-LRB-
cord-259603-bh198xgl	42	10	3CL	3CL	NNP
cord-259603-bh198xgl	42	11	pro	pro	JJ
cord-259603-bh198xgl	42	12	)	)	-RRB-
cord-259603-bh198xgl	42	13	proteases	protease	NNS
cord-259603-bh198xgl	42	14	and	and	CC
cord-259603-bh198xgl	42	15	their	-PRON-	PRP$
cord-259603-bh198xgl	42	16	cleavage	cleavage	NN
cord-259603-bh198xgl	42	17	sites	site	NNS
cord-259603-bh198xgl	42	18	are	be	VBP
cord-259603-bh198xgl	42	19	indicated	indicate	VBN
cord-259603-bh198xgl	42	20	in	in	IN
cord-259603-bh198xgl	42	21	matching	match	VBG
cord-259603-bh198xgl	42	22	colors	color	NNS
cord-259603-bh198xgl	42	23	.	.	.
cord-259603-bh198xgl	43	1	The	the	DT
cord-259603-bh198xgl	43	2	resulting	result	VBG
cord-259603-bh198xgl	43	3	16	16	CD
cord-259603-bh198xgl	43	4	cleavage	cleavage	NN
cord-259603-bh198xgl	43	5	products	product	NNS
cord-259603-bh198xgl	43	6	(	(	-LRB-
cord-259603-bh198xgl	43	7	nonstructural	nonstructural	JJ
cord-259603-bh198xgl	43	8	proteins	protein	NNS
cord-259603-bh198xgl	43	9	(	(	-LRB-
cord-259603-bh198xgl	43	10	nsps	nsps	NNP
cord-259603-bh198xgl	43	11	)	)	-RRB-
cord-259603-bh198xgl	43	12	)	)	-RRB-
cord-259603-bh198xgl	43	13	are	be	VBP
cord-259603-bh198xgl	43	14	indicated	indicate	VBN
cord-259603-bh198xgl	43	15	,	,	,
cord-259603-bh198xgl	43	16	as	as	IN
cord-259603-bh198xgl	43	17	are	be	VBP
cord-259603-bh198xgl	43	18	the	the	DT
cord-259603-bh198xgl	43	19	conserved	conserve	VBN
cord-259603-bh198xgl	43	20	replicase	replicase	NN
cord-259603-bh198xgl	43	21	domains	domain	NNS
cord-259603-bh198xgl	43	22	that	that	WDT
cord-259603-bh198xgl	43	23	are	be	VBP
cord-259603-bh198xgl	43	24	relevant	relevant	JJ
cord-259603-bh198xgl	43	25	for	for	IN
cord-259603-bh198xgl	43	26	this	this	DT
cord-259603-bh198xgl	43	27	review	review	NN
cord-259603-bh198xgl	43	28	.	.	.
cord-259603-bh198xgl	44	1	Domain	domain	NN
cord-259603-bh198xgl	44	2	abbreviations	abbreviation	NNS
cord-259603-bh198xgl	44	3	and	and	CC
cord-259603-bh198xgl	44	4	corresponding	correspond	VBG
cord-259603-bh198xgl	44	5	nsp	nsp	NNP
cord-259603-bh198xgl	44	6	numbers	number	NNS
cord-259603-bh198xgl	44	7	:	:	:
cord-259603-bh198xgl	45	1	PL	PL	NNP
cord-259603-bh198xgl	45	2	pro	pro	JJ
cord-259603-bh198xgl	45	3	,	,	,
cord-259603-bh198xgl	45	4	papain	papain	NN
cord-259603-bh198xgl	45	5	-	-	HYPH
cord-259603-bh198xgl	45	6	like	like	JJ
cord-259603-bh198xgl	45	7	proteinase	proteinase	NN
cord-259603-bh198xgl	45	8	(	(	-LRB-
cord-259603-bh198xgl	45	9	nsp3	nsp3	NNS
cord-259603-bh198xgl	45	10	)	)	-RRB-
cord-259603-bh198xgl	45	11	;	;	:
cord-259603-bh198xgl	45	12	3CL	3CL	NNP
cord-259603-bh198xgl	45	13	pro	pro	NNP
cord-259603-bh198xgl	45	14	,	,	,
cord-259603-bh198xgl	45	15	3C	3c	NN
cord-259603-bh198xgl	45	16	-	-	HYPH
cord-259603-bh198xgl	45	17	like	like	JJ
cord-259603-bh198xgl	45	18	proteinase	proteinase	NN
cord-259603-bh198xgl	45	19	(	(	-LRB-
cord-259603-bh198xgl	45	20	nsp5	nsp5	NN
cord-259603-bh198xgl	45	21	)	)	-RRB-
cord-259603-bh198xgl	45	22	;	;	:
cord-259603-bh198xgl	45	23	TM	TM	NNP
cord-259603-bh198xgl	45	24	,	,	,
cord-259603-bh198xgl	45	25	transmembrane	transmembrane	NN
cord-259603-bh198xgl	45	26	domain	domain	NN
cord-259603-bh198xgl	45	27	(	(	-LRB-
cord-259603-bh198xgl	45	28	nsp3	nsp3	NNS
cord-259603-bh198xgl	45	29	,	,	,
cord-259603-bh198xgl	45	30	nsp4	nsp4	NNP
cord-259603-bh198xgl	45	31	,	,	,
cord-259603-bh198xgl	45	32	and	and	CC
cord-259603-bh198xgl	45	33	nsp6	nsp6	NN
cord-259603-bh198xgl	45	34	)	)	-RRB-
cord-259603-bh198xgl	45	35	;	;	:
cord-259603-bh198xgl	45	36	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	45	37	,	,	,
cord-259603-bh198xgl	45	38	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	45	39	RdRp	RdRp	NNP
cord-259603-bh198xgl	45	40	-	-	HYPH
cord-259603-bh198xgl	45	41	associated	associate	VBN
cord-259603-bh198xgl	45	42	nucleotidyl	nucleotidyl	NNP
cord-259603-bh198xgl	45	43	transferase	transferase	NNP
cord-259603-bh198xgl	45	44	(	(	-LRB-
cord-259603-bh198xgl	45	45	nsp12	nsp12	CD
cord-259603-bh198xgl	45	46	)	)	-RRB-
cord-259603-bh198xgl	45	47	;	;	:
cord-259603-bh198xgl	45	48	RdRp	RdRp	NNP
cord-259603-bh198xgl	45	49	,	,	,
cord-259603-bh198xgl	45	50	RNA	RNA	NNP
cord-259603-bh198xgl	45	51	-	-	HYPH
cord-259603-bh198xgl	45	52	dependent	dependent	JJ
cord-259603-bh198xgl	45	53	RNA	RNA	NNP
cord-259603-bh198xgl	45	54	polymerase	polymerase	NN
cord-259603-bh198xgl	45	55	(	(	-LRB-
cord-259603-bh198xgl	45	56	nsp12	nsp12	CD
cord-259603-bh198xgl	45	57	)	)	-RRB-
cord-259603-bh198xgl	45	58	;	;	:
cord-259603-bh198xgl	45	59	ZBD	ZBD	NNP
cord-259603-bh198xgl	45	60	,	,	,
cord-259603-bh198xgl	45	61	zinc	zinc	NN
cord-259603-bh198xgl	45	62	-	-	HYPH
cord-259603-bh198xgl	45	63	binding	bind	VBG
cord-259603-bh198xgl	45	64	domain	domain	NN
cord-259603-bh198xgl	45	65	(	(	-LRB-
cord-259603-bh198xgl	45	66	nsp13	nsp13	NNP
cord-259603-bh198xgl	45	67	)	)	-RRB-
cord-259603-bh198xgl	45	68	;	;	:
cord-259603-bh198xgl	45	69	HEL1	HEL1	NNP
cord-259603-bh198xgl	45	70	,	,	,
cord-259603-bh198xgl	45	71	superfamily	superfamily	NN
cord-259603-bh198xgl	45	72	1	1	CD
cord-259603-bh198xgl	45	73	helicase	helicase	NNP
cord-259603-bh198xgl	45	74	(	(	-LRB-
cord-259603-bh198xgl	45	75	nsp13	nsp13	NNP
cord-259603-bh198xgl	45	76	)	)	-RRB-
cord-259603-bh198xgl	45	77	;	;	:
cord-259603-bh198xgl	45	78	ExoN	ExoN	NNP
cord-259603-bh198xgl	45	79	,	,	,
cord-259603-bh198xgl	45	80	exoribonuclease	exoribonuclease	NNP
cord-259603-bh198xgl	45	81	(	(	-LRB-
cord-259603-bh198xgl	45	82	nsp14	nsp14	NNP
cord-259603-bh198xgl	45	83	)	)	-RRB-
cord-259603-bh198xgl	45	84	;	;	.
cord-259603-bh198xgl	46	1	N7-MT	N7-MT	NNP
cord-259603-bh198xgl	46	2	,	,	,
cord-259603-bh198xgl	46	3	N7-methyl	N7-methyl	NNP
cord-259603-bh198xgl	46	4	transferase	transferase	NN
cord-259603-bh198xgl	46	5	(	(	-LRB-
cord-259603-bh198xgl	46	6	nsp14	nsp14	NN
cord-259603-bh198xgl	46	7	)	)	-RRB-
cord-259603-bh198xgl	47	1	;	;	:
cord-259603-bh198xgl	47	2	endoU	endoU	NNP
cord-259603-bh198xgl	47	3	,	,	,
cord-259603-bh198xgl	47	4	uridylate	uridylate	JJ
cord-259603-bh198xgl	47	5	-	-	HYPH
cord-259603-bh198xgl	47	6	specific	specific	JJ
cord-259603-bh198xgl	47	7	endoribonuclease	endoribonuclease	NN
cord-259603-bh198xgl	47	8	(	(	-LRB-
cord-259603-bh198xgl	47	9	nsp15	nsp15	NNP
cord-259603-bh198xgl	47	10	)	)	-RRB-
cord-259603-bh198xgl	47	11	;	;	:
cord-259603-bh198xgl	47	12	2	2	CD
cord-259603-bh198xgl	47	13	0	0	CD
cord-259603-bh198xgl	47	14	-O	-o	CD
cord-259603-bh198xgl	47	15	-	-	HYPH
cord-259603-bh198xgl	47	16	MT	MT	NNP
cord-259603-bh198xgl	47	17	,	,	,
cord-259603-bh198xgl	47	18	2	2	CD
cord-259603-bh198xgl	47	19	0	0	NFP
cord-259603-bh198xgl	47	20	-Omethyl	-omethyl	NN
cord-259603-bh198xgl	47	21	transferase	transferase	NN
cord-259603-bh198xgl	47	22	(	(	-LRB-
cord-259603-bh198xgl	47	23	nsp16	nsp16	NNS
cord-259603-bh198xgl	47	24	)	)	-RRB-
cord-259603-bh198xgl	47	25	.	.	.
cord-259603-bh198xgl	48	1	upstream	upstream	RB
cord-259603-bh198xgl	48	2	of	of	IN
cord-259603-bh198xgl	48	3	the	the	DT
cord-259603-bh198xgl	48	4	ORF1a	ORF1a	NNP
cord-259603-bh198xgl	48	5	termination	termination	NN
cord-259603-bh198xgl	48	6	codon	codon	NN
cord-259603-bh198xgl	48	7	(	(	-LRB-
cord-259603-bh198xgl	48	8	Brierley	Brierley	NNP
cord-259603-bh198xgl	48	9	et	et	NNP
cord-259603-bh198xgl	48	10	al	al	NNP
cord-259603-bh198xgl	48	11	.	.	NNP
cord-259603-bh198xgl	48	12	,	,	,
cord-259603-bh198xgl	48	13	1989	1989	CD
cord-259603-bh198xgl	48	14	)	)	-RRB-
cord-259603-bh198xgl	48	15	.	.	.
cord-259603-bh198xgl	49	1	The	the	DT
cord-259603-bh198xgl	49	2	efficiency	efficiency	NN
cord-259603-bh198xgl	49	3	of	of	IN
cord-259603-bh198xgl	49	4	this	this	DT
cord-259603-bh198xgl	49	5	highly	highly	RB
cord-259603-bh198xgl	49	6	conserved	conserved	JJ
cord-259603-bh198xgl	49	7	frameshift	frameshift	NN
cord-259603-bh198xgl	49	8	event	event	NN
cord-259603-bh198xgl	49	9	,	,	,
cord-259603-bh198xgl	49	10	which	which	WDT
cord-259603-bh198xgl	49	11	may	may	MD
cord-259603-bh198xgl	49	12	approach	approach	VB
cord-259603-bh198xgl	49	13	50	50	CD
cord-259603-bh198xgl	49	14	%	%	NN
cord-259603-bh198xgl	49	15	in	in	IN
cord-259603-bh198xgl	49	16	the	the	DT
cord-259603-bh198xgl	49	17	case	case	NN
cord-259603-bh198xgl	49	18	of	of	IN
cord-259603-bh198xgl	49	19	CoVs	CoVs	NNP
cord-259603-bh198xgl	49	20	(	(	-LRB-
cord-259603-bh198xgl	49	21	Irigoyen	Irigoyen	NNP
cord-259603-bh198xgl	49	22	et	et	NNP
cord-259603-bh198xgl	49	23	al	al	NNP
cord-259603-bh198xgl	49	24	.	.	NNP
cord-259603-bh198xgl	49	25	,	,	,
cord-259603-bh198xgl	49	26	2016	2016	CD
cord-259603-bh198xgl	49	27	)	)	-RRB-
cord-259603-bh198xgl	49	28	,	,	,
cord-259603-bh198xgl	49	29	is	be	VBZ
cord-259603-bh198xgl	49	30	promoted	promote	VBN
cord-259603-bh198xgl	49	31	by	by	IN
cord-259603-bh198xgl	49	32	specific	specific	JJ
cord-259603-bh198xgl	49	33	primary	primary	JJ
cord-259603-bh198xgl	49	34	and	and	CC
cord-259603-bh198xgl	49	35	higher	high	JJR
cord-259603-bh198xgl	49	36	-	-	HYPH
cord-259603-bh198xgl	49	37	order	order	NN
cord-259603-bh198xgl	49	38	RNA	RNA	NNP
cord-259603-bh198xgl	49	39	structures	structure	NNS
cord-259603-bh198xgl	49	40	.	.	.
cord-259603-bh198xgl	50	1	As	as	IN
cord-259603-bh198xgl	50	2	a	a	DT
cord-259603-bh198xgl	50	3	result	result	NN
cord-259603-bh198xgl	50	4	,	,	,
cord-259603-bh198xgl	50	5	in	in	IN
cord-259603-bh198xgl	50	6	CoV	cov	NN
cord-259603-bh198xgl	50	7	-	-	HYPH
cord-259603-bh198xgl	50	8	infected	infect	VBN
cord-259603-bh198xgl	50	9	cells	cell	NNS
cord-259603-bh198xgl	50	10	,	,	,
cord-259603-bh198xgl	50	11	the	the	DT
cord-259603-bh198xgl	50	12	replicase	replicase	NN
cord-259603-bh198xgl	50	13	subunits	subunit	NNS
cord-259603-bh198xgl	50	14	encoded	encode	VBN
cord-259603-bh198xgl	50	15	in	in	IN
cord-259603-bh198xgl	50	16	ORF1a	ORF1a	NNP
cord-259603-bh198xgl	50	17	are	be	VBP
cord-259603-bh198xgl	50	18	overexpressed	overexpresse	VBN
cord-259603-bh198xgl	50	19	in	in	IN
cord-259603-bh198xgl	50	20	a	a	DT
cord-259603-bh198xgl	50	21	fixed	fix	VBN
cord-259603-bh198xgl	50	22	ratio	ratio	NN
cord-259603-bh198xgl	50	23	relative	relative	JJ
cord-259603-bh198xgl	50	24	to	to	IN
cord-259603-bh198xgl	50	25	the	the	DT
cord-259603-bh198xgl	50	26	proteins	protein	NNS
cord-259603-bh198xgl	50	27	encoded	encode	VBN
cord-259603-bh198xgl	50	28	in	in	IN
cord-259603-bh198xgl	50	29	ORF1b	ORF1b	NNP
cord-259603-bh198xgl	50	30	.	.	.
cord-259603-bh198xgl	51	1	The	the	DT
cord-259603-bh198xgl	51	2	primary	primary	JJ
cord-259603-bh198xgl	51	3	translation	translation	NN
cord-259603-bh198xgl	51	4	products	product	NNS
cord-259603-bh198xgl	51	5	of	of	IN
cord-259603-bh198xgl	51	6	the	the	DT
cord-259603-bh198xgl	51	7	CoV	CoV	NNP
cord-259603-bh198xgl	51	8	replicase	replicase	NNP
cord-259603-bh198xgl	51	9	are	be	VBP
cord-259603-bh198xgl	51	10	two	two	CD
cord-259603-bh198xgl	51	11	huge	huge	JJ
cord-259603-bh198xgl	51	12	polyproteins	polyprotein	NNS
cord-259603-bh198xgl	51	13	,	,	,
cord-259603-bh198xgl	51	14	the	the	DT
cord-259603-bh198xgl	51	15	ORF1a	ORF1a	NNP
cord-259603-bh198xgl	51	16	-	-	HYPH
cord-259603-bh198xgl	51	17	encoded	encode	VBN
cord-259603-bh198xgl	51	18	pp1a	pp1a	NNP
cord-259603-bh198xgl	51	19	and	and	CC
cord-259603-bh198xgl	51	20	the	the	DT
cord-259603-bh198xgl	51	21	C	C	NNP
cord-259603-bh198xgl	51	22	-	-	HYPH
cord-259603-bh198xgl	51	23	terminally	terminally	RB
cord-259603-bh198xgl	51	24	extended	extend	VBD
cord-259603-bh198xgl	51	25	pp1ab	pp1ab	NNP
cord-259603-bh198xgl	51	26	frameshift	frameshift	NN
cord-259603-bh198xgl	51	27	product	product	NN
cord-259603-bh198xgl	51	28	(	(	-LRB-
cord-259603-bh198xgl	51	29	Fig	Fig	NNP
cord-259603-bh198xgl	51	30	.	.	.
cord-259603-bh198xgl	51	31	1	1	CD
cord-259603-bh198xgl	51	32	)	)	-RRB-
cord-259603-bh198xgl	51	33	.	.	.
cord-259603-bh198xgl	52	1	The	the	DT
cord-259603-bh198xgl	52	2	former	former	JJ
cord-259603-bh198xgl	52	3	is	be	VBZ
cord-259603-bh198xgl	52	4	roughly	roughly	RB
cord-259603-bh198xgl	52	5	4000	4000	CD
cord-259603-bh198xgl	52	6	-	-	SYM
cord-259603-bh198xgl	52	7	4500	4500	CD
cord-259603-bh198xgl	52	8	amino	amino	NN
cord-259603-bh198xgl	52	9	acids	acid	NNS
cord-259603-bh198xgl	52	10	long	long	RB
cord-259603-bh198xgl	52	11	,	,	,
cord-259603-bh198xgl	52	12	depending	depend	VBG
cord-259603-bh198xgl	52	13	on	on	IN
cord-259603-bh198xgl	52	14	the	the	DT
cord-259603-bh198xgl	52	15	CoV	cov	NN
cord-259603-bh198xgl	52	16	species	specie	NNS
cord-259603-bh198xgl	52	17	analyzed	analyze	VBN
cord-259603-bh198xgl	52	18	.	.	.
cord-259603-bh198xgl	53	1	The	the	DT
cord-259603-bh198xgl	53	2	size	size	NN
cord-259603-bh198xgl	53	3	of	of	IN
cord-259603-bh198xgl	53	4	the	the	DT
cord-259603-bh198xgl	53	5	ORF1b	ORF1b	NNP
cord-259603-bh198xgl	53	6	-	-	HYPH
cord-259603-bh198xgl	53	7	encoded	encode	VBN
cord-259603-bh198xgl	53	8	extension	extension	NN
cord-259603-bh198xgl	53	9	is	be	VBZ
cord-259603-bh198xgl	53	10	more	more	RBR
cord-259603-bh198xgl	53	11	conserved	conserved	JJ
cord-259603-bh198xgl	53	12	(	(	-LRB-
cord-259603-bh198xgl	53	13	around	around	IN
cord-259603-bh198xgl	53	14	2700	2700	CD
cord-259603-bh198xgl	53	15	residues	residue	NNS
cord-259603-bh198xgl	53	16	)	)	-RRB-
cord-259603-bh198xgl	53	17	,	,	,
cord-259603-bh198xgl	53	18	resulting	result	VBG
cord-259603-bh198xgl	53	19	in	in	IN
cord-259603-bh198xgl	53	20	pp1ab	pp1ab	NNP
cord-259603-bh198xgl	53	21	sizes	size	NNS
cord-259603-bh198xgl	53	22	in	in	IN
cord-259603-bh198xgl	53	23	the	the	DT
cord-259603-bh198xgl	53	24	range	range	NN
cord-259603-bh198xgl	53	25	of	of	IN
cord-259603-bh198xgl	53	26	6700	6700	CD
cord-259603-bh198xgl	53	27	-	-	HYPH
cord-259603-bh198xgl	53	28	7200	7200	CD
cord-259603-bh198xgl	53	29	amino	amino	NN
cord-259603-bh198xgl	53	30	acids	acid	NNS
cord-259603-bh198xgl	53	31	.	.	.
cord-259603-bh198xgl	54	1	Probably	probably	RB
cord-259603-bh198xgl	54	2	already	already	RB
cord-259603-bh198xgl	54	3	during	during	IN
cord-259603-bh198xgl	54	4	their	-PRON-	PRP$
cord-259603-bh198xgl	54	5	synthesis	synthesis	NN
cord-259603-bh198xgl	54	6	,	,	,
cord-259603-bh198xgl	54	7	either	either	CC
cord-259603-bh198xgl	54	8	two	two	CD
cord-259603-bh198xgl	54	9	or	or	CC
cord-259603-bh198xgl	54	10	three	three	CD
cord-259603-bh198xgl	54	11	ORF1aencoded	ORF1aencoded	NNP
cord-259603-bh198xgl	54	12	proteases	protease	NNS
cord-259603-bh198xgl	54	13	initiate	initiate	VBP
cord-259603-bh198xgl	54	14	the	the	DT
cord-259603-bh198xgl	54	15	proteolytic	proteolytic	JJ
cord-259603-bh198xgl	54	16	cleavage	cleavage	NN
cord-259603-bh198xgl	54	17	of	of	IN
cord-259603-bh198xgl	54	18	pp1a	pp1a	NNP
cord-259603-bh198xgl	54	19	and	and	CC
cord-259603-bh198xgl	54	20	pp1ab	pp1ab	NNP
cord-259603-bh198xgl	54	21	to	to	TO
cord-259603-bh198xgl	54	22	release	release	VB
cord-259603-bh198xgl	54	23	(	(	-LRB-
cord-259603-bh198xgl	54	24	sometimes	sometimes	RB
cord-259603-bh198xgl	54	25	)	)	-RRB-
cord-259603-bh198xgl	54	26	15	15	CD
cord-259603-bh198xgl	54	27	or	or	CC
cord-259603-bh198xgl	54	28	(	(	-LRB-
cord-259603-bh198xgl	54	29	mostly	mostly	RB
cord-259603-bh198xgl	54	30	)	)	-RRB-
cord-259603-bh198xgl	54	31	16	16	CD
cord-259603-bh198xgl	54	32	functional	functional	JJ
cord-259603-bh198xgl	54	33	nonstructural	nonstructural	JJ
cord-259603-bh198xgl	54	34	proteins	protein	NNS
cord-259603-bh198xgl	54	35	(	(	-LRB-
cord-259603-bh198xgl	54	36	nsps	nsp	NNS
cord-259603-bh198xgl	54	37	;	;	:
cord-259603-bh198xgl	54	38	Fig	Fig	NNP
cord-259603-bh198xgl	54	39	.	.	NNP
cord-259603-bh198xgl	54	40	1	1	CD
cord-259603-bh198xgl	54	41	)	)	-RRB-
cord-259603-bh198xgl	54	42	.	.	.
cord-259603-bh198xgl	55	1	The	the	DT
cord-259603-bh198xgl	55	2	highly	highly	RB
cord-259603-bh198xgl	55	3	conserved	conserve	VBN
cord-259603-bh198xgl	55	4	nsp5	nsp5	NN
cord-259603-bh198xgl	55	5	protease	protease	NN
cord-259603-bh198xgl	55	6	has	have	VBZ
cord-259603-bh198xgl	55	7	a	a	DT
cord-259603-bh198xgl	55	8	chymotrypsin	chymotrypsin	JJ
cord-259603-bh198xgl	55	9	-	-	HYPH
cord-259603-bh198xgl	55	10	like	like	JJ
cord-259603-bh198xgl	55	11	fold	fold	JJ
cord-259603-bh198xgl	55	12	(	(	-LRB-
cord-259603-bh198xgl	55	13	3Clike	3clike	JJ
cord-259603-bh198xgl	55	14	protease	protease	NN
cord-259603-bh198xgl	55	15	,	,	,
cord-259603-bh198xgl	55	16	3CL	3CL	NNP
cord-259603-bh198xgl	55	17	pro	pro	JJ
cord-259603-bh198xgl	55	18	)	)	-RRB-
cord-259603-bh198xgl	56	1	(	(	-LRB-
cord-259603-bh198xgl	56	2	Anand	Anand	NNP
cord-259603-bh198xgl	56	3	et	et	NNP
cord-259603-bh198xgl	56	4	al	al	NNP
cord-259603-bh198xgl	56	5	.	.	NNP
cord-259603-bh198xgl	56	6	,	,	,
cord-259603-bh198xgl	56	7	2002	2002	CD
cord-259603-bh198xgl	57	1	(	(	-LRB-
cord-259603-bh198xgl	57	2	Anand	Anand	NNP
cord-259603-bh198xgl	57	3	et	et	NNP
cord-259603-bh198xgl	57	4	al	al	NNP
cord-259603-bh198xgl	57	5	.	.	.
cord-259603-bh198xgl	58	1	,	,	,
cord-259603-bh198xgl	58	2	,	,	,
cord-259603-bh198xgl	58	3	2003	2003	CD
cord-259603-bh198xgl	58	4	Gorbalenya	Gorbalenya	NNP
cord-259603-bh198xgl	58	5	et	et	NNP
cord-259603-bh198xgl	58	6	al	al	NNP
cord-259603-bh198xgl	58	7	.	.	NNP
cord-259603-bh198xgl	58	8	,	,	,
cord-259603-bh198xgl	58	9	1989	1989	CD
cord-259603-bh198xgl	58	10	)	)	-RRB-
cord-259603-bh198xgl	58	11	and	and	CC
cord-259603-bh198xgl	58	12	is	be	VBZ
cord-259603-bh198xgl	58	13	the	the	DT
cord-259603-bh198xgl	58	14	viral	viral	JJ
cord-259603-bh198xgl	58	15	"	"	``
cord-259603-bh198xgl	58	16	main	main	JJ
cord-259603-bh198xgl	58	17	protease	protease	NN
cord-259603-bh198xgl	58	18	"	"	''
cord-259603-bh198xgl	58	19	(	(	-LRB-
cord-259603-bh198xgl	58	20	therefore	therefore	RB
cord-259603-bh198xgl	58	21	sometimes	sometimes	RB
cord-259603-bh198xgl	58	22	also	also	RB
cord-259603-bh198xgl	58	23	referred	refer	VBD
cord-259603-bh198xgl	58	24	to	to	IN
cord-259603-bh198xgl	58	25	as	as	IN
cord-259603-bh198xgl	58	26	M	M	NNP
cord-259603-bh198xgl	58	27	pro	pro	FW
cord-259603-bh198xgl	58	28	)	)	-RRB-
cord-259603-bh198xgl	58	29	.	.	.
cord-259603-bh198xgl	59	1	The	the	DT
cord-259603-bh198xgl	59	2	3CL	3cl	CD
cord-259603-bh198xgl	59	3	pro	pro	NN
cord-259603-bh198xgl	59	4	cleaves	cleave	VBZ
cord-259603-bh198xgl	59	5	the	the	DT
cord-259603-bh198xgl	59	6	nsp4-nsp11	nsp4-nsp11	JJ
cord-259603-bh198xgl	59	7	part	part	NN
cord-259603-bh198xgl	59	8	of	of	IN
cord-259603-bh198xgl	59	9	pp1a	pp1a	NNP
cord-259603-bh198xgl	59	10	and	and	CC
cord-259603-bh198xgl	59	11	the	the	DT
cord-259603-bh198xgl	59	12	nsp4-nsp16	nsp4-nsp16	JJ
cord-259603-bh198xgl	59	13	part	part	NN
cord-259603-bh198xgl	59	14	of	of	IN
cord-259603-bh198xgl	59	15	pp1ab	pp1ab	NNP
cord-259603-bh198xgl	59	16	at	at	IN
cord-259603-bh198xgl	59	17	7	7	CD
cord-259603-bh198xgl	59	18	and	and	CC
cord-259603-bh198xgl	59	19	11	11	CD
cord-259603-bh198xgl	59	20	conserved	conserve	VBN
cord-259603-bh198xgl	59	21	sites	site	NNS
cord-259603-bh198xgl	59	22	,	,	,
cord-259603-bh198xgl	59	23	respectively	respectively	RB
cord-259603-bh198xgl	59	24	.	.	.
cord-259603-bh198xgl	60	1	These	these	DT
cord-259603-bh198xgl	60	2	sites	site	NNS
cord-259603-bh198xgl	60	3	can	can	MD
cord-259603-bh198xgl	60	4	be	be	VB
cord-259603-bh198xgl	60	5	summarized	summarize	VBN
cord-259603-bh198xgl	60	6	with	with	IN
cord-259603-bh198xgl	60	7	the	the	DT
cord-259603-bh198xgl	60	8	P4-P2	P4-P2	NNP
cord-259603-bh198xgl	60	9	0	0	CD
cord-259603-bh198xgl	60	10	consensus	consensus	NN
cord-259603-bh198xgl	60	11	motif	motif	NN
cord-259603-bh198xgl	60	12	(	(	-LRB-
cord-259603-bh198xgl	60	13	small)-X-(L	small)-x-(l	CD
cord-259603-bh198xgl	60	14	/	/	SYM
cord-259603-bh198xgl	60	15	I	I	NNP
cord-259603-bh198xgl	60	16	/	/	SYM
cord-259603-bh198xgl	60	17	V	V	NNP
cord-259603-bh198xgl	60	18	/	/	SYM
cord-259603-bh198xgl	60	19	F	F	NNP
cord-259603-bh198xgl	60	20	/	/	SYM
cord-259603-bh198xgl	60	21	M)-Q#(S	m)-q#(	VBZ
cord-259603-bh198xgl	60	22	/	/	SYM
cord-259603-bh198xgl	60	23	A	a	NN
cord-259603-bh198xgl	60	24	/	/	SYM
cord-259603-bh198xgl	60	25	G	G	NNP
cord-259603-bh198xgl	60	26	)	)	-RRB-
cord-259603-bh198xgl	60	27	,	,	,
cord-259603-bh198xgl	60	28	where	where	WRB
cord-259603-bh198xgl	60	29	X	x	NN
cord-259603-bh198xgl	60	30	is	be	VBZ
cord-259603-bh198xgl	60	31	any	any	DT
cord-259603-bh198xgl	60	32	amino	amino	NN
cord-259603-bh198xgl	60	33	acid	acid	NN
cord-259603-bh198xgl	60	34	and	and	CC
cord-259603-bh198xgl	60	35	#	#	NN
cord-259603-bh198xgl	60	36	represents	represent	VBZ
cord-259603-bh198xgl	60	37	the	the	DT
cord-259603-bh198xgl	60	38	cleavage	cleavage	NN
cord-259603-bh198xgl	60	39	.	.	.
cord-259603-bh198xgl	61	1	The	the	DT
cord-259603-bh198xgl	61	2	processing	processing	NN
cord-259603-bh198xgl	61	3	of	of	IN
cord-259603-bh198xgl	61	4	three	three	CD
cord-259603-bh198xgl	61	5	sites	site	NNS
cord-259603-bh198xgl	61	6	in	in	IN
cord-259603-bh198xgl	61	7	the	the	DT
cord-259603-bh198xgl	61	8	nsp1-nsp4	nsp1-nsp4	NNP
cord-259603-bh198xgl	61	9	region	region	NN
cord-259603-bh198xgl	61	10	is	be	VBZ
cord-259603-bh198xgl	61	11	performed	perform	VBN
cord-259603-bh198xgl	61	12	by	by	IN
cord-259603-bh198xgl	61	13	one	one	CD
cord-259603-bh198xgl	61	14	or	or	CC
cord-259603-bh198xgl	61	15	two	two	CD
cord-259603-bh198xgl	61	16	papain	papain	NN
cord-259603-bh198xgl	61	17	-	-	HYPH
cord-259603-bh198xgl	61	18	like	like	JJ
cord-259603-bh198xgl	61	19	proteases	protease	NNS
cord-259603-bh198xgl	61	20	(	(	-LRB-
cord-259603-bh198xgl	61	21	PL	PL	NNP
cord-259603-bh198xgl	61	22	pro	pro	FW
cord-259603-bh198xgl	61	23	)	)	-RRB-
cord-259603-bh198xgl	61	24	residing	reside	VBG
cord-259603-bh198xgl	61	25	in	in	IN
cord-259603-bh198xgl	61	26	the	the	DT
cord-259603-bh198xgl	61	27	very	very	RB
cord-259603-bh198xgl	61	28	large	large	JJ
cord-259603-bh198xgl	61	29	nsp3	nsp3	NNS
cord-259603-bh198xgl	61	30	subunit	subunit	NN
cord-259603-bh198xgl	61	31	(	(	-LRB-
cord-259603-bh198xgl	61	32	Mielech	Mielech	NNP
cord-259603-bh198xgl	61	33	et	et	NNP
cord-259603-bh198xgl	61	34	al	al	NNP
cord-259603-bh198xgl	61	35	.	.	NNP
cord-259603-bh198xgl	61	36	,	,	,
cord-259603-bh198xgl	61	37	2014	2014	CD
cord-259603-bh198xgl	61	38	)	)	-RRB-
cord-259603-bh198xgl	61	39	.	.	.
cord-259603-bh198xgl	62	1	Whereas	whereas	IN
cord-259603-bh198xgl	62	2	alphacoronaviruses	alphacoronaviruse	NNS
cord-259603-bh198xgl	62	3	and	and	CC
cord-259603-bh198xgl	62	4	most	most	JJS
cord-259603-bh198xgl	62	5	betacoronaviruses	betacoronaviruse	NNS
cord-259603-bh198xgl	62	6	(	(	-LRB-
cord-259603-bh198xgl	62	7	though	though	IN
cord-259603-bh198xgl	62	8	not	not	RB
cord-259603-bh198xgl	62	9	SARS	SARS	NNP
cord-259603-bh198xgl	62	10	-	-	HYPH
cord-259603-bh198xgl	62	11	CoV	CoV	NNP
cord-259603-bh198xgl	62	12	and	and	CC
cord-259603-bh198xgl	62	13	MERS	MERS	NNP
cord-259603-bh198xgl	62	14	-	-	HYPH
cord-259603-bh198xgl	62	15	CoV	CoV	NNP
cord-259603-bh198xgl	62	16	)	)	-RRB-
cord-259603-bh198xgl	62	17	have	have	VBP
cord-259603-bh198xgl	62	18	two	two	CD
cord-259603-bh198xgl	62	19	PL	pl	NN
cord-259603-bh198xgl	62	20	pro	pro	NN
cord-259603-bh198xgl	62	21	domains	domain	NNS
cord-259603-bh198xgl	62	22	in	in	IN
cord-259603-bh198xgl	62	23	their	-PRON-	PRP$
cord-259603-bh198xgl	62	24	nsp3	nsp3	NNS
cord-259603-bh198xgl	62	25	,	,	,
cord-259603-bh198xgl	62	26	presumably	presumably	RB
cord-259603-bh198xgl	62	27	the	the	DT
cord-259603-bh198xgl	62	28	result	result	NN
cord-259603-bh198xgl	62	29	of	of	IN
cord-259603-bh198xgl	62	30	an	an	DT
cord-259603-bh198xgl	62	31	ancient	ancient	JJ
cord-259603-bh198xgl	62	32	duplication	duplication	NN
cord-259603-bh198xgl	62	33	event	event	NN
cord-259603-bh198xgl	62	34	,	,	,
cord-259603-bh198xgl	62	35	gamma	gamma	NN
cord-259603-bh198xgl	62	36	-	-	HYPH
cord-259603-bh198xgl	62	37	and	and	CC
cord-259603-bh198xgl	62	38	deltacoronaviruses	deltacoronaviruse	NNS
cord-259603-bh198xgl	62	39	have	have	VBP
cord-259603-bh198xgl	62	40	only	only	RB
cord-259603-bh198xgl	62	41	a	a	DT
cord-259603-bh198xgl	62	42	single	single	JJ
cord-259603-bh198xgl	62	43	PL	pl	NN
cord-259603-bh198xgl	62	44	pro	pro	NN
cord-259603-bh198xgl	62	45	.	.	.
cord-259603-bh198xgl	63	1	The	the	DT
cord-259603-bh198xgl	63	2	cleavage	cleavage	NN
cord-259603-bh198xgl	63	3	sites	site	NNS
cord-259603-bh198xgl	63	4	(	(	-LRB-
cord-259603-bh198xgl	63	5	LXGG	LXGG	NNP
cord-259603-bh198xgl	63	6	#	#	JJS
cord-259603-bh198xgl	63	7	or	or	CC
cord-259603-bh198xgl	63	8	similar	similar	JJ
cord-259603-bh198xgl	63	9	)	)	-RRB-
cord-259603-bh198xgl	63	10	resemble	resemble	VB
cord-259603-bh198xgl	63	11	the	the	DT
cord-259603-bh198xgl	63	12	C	c	NN
cord-259603-bh198xgl	63	13	-	-	HYPH
cord-259603-bh198xgl	63	14	terminal	terminal	NN
cord-259603-bh198xgl	63	15	LRGG	LRGG	NNP
cord-259603-bh198xgl	63	16	#	#	NN
cord-259603-bh198xgl	63	17	motif	motif	NN
cord-259603-bh198xgl	63	18	of	of	IN
cord-259603-bh198xgl	63	19	ubiquitin	ubiquitin	NN
cord-259603-bh198xgl	63	20	,	,	,
cord-259603-bh198xgl	63	21	which	which	WDT
cord-259603-bh198xgl	63	22	explains	explain	VBZ
cord-259603-bh198xgl	63	23	why	why	WRB
cord-259603-bh198xgl	63	24	CoV	cov	NN
cord-259603-bh198xgl	63	25	PL	pl	NN
cord-259603-bh198xgl	63	26	pro	pro	JJ
cord-259603-bh198xgl	63	27	domains	domain	NNS
cord-259603-bh198xgl	63	28	were	be	VBD
cord-259603-bh198xgl	63	29	found	find	VBN
cord-259603-bh198xgl	63	30	capable	capable	JJ
cord-259603-bh198xgl	63	31	to	to	TO
cord-259603-bh198xgl	63	32	also	also	RB
cord-259603-bh198xgl	63	33	act	act	VB
cord-259603-bh198xgl	63	34	as	as	IN
cord-259603-bh198xgl	63	35	deubiquitinases	deubiquitinase	NNS
cord-259603-bh198xgl	63	36	(	(	-LRB-
cord-259603-bh198xgl	63	37	Ratia	Ratia	NNP
cord-259603-bh198xgl	63	38	et	et	NNP
cord-259603-bh198xgl	63	39	al	al	NNP
cord-259603-bh198xgl	63	40	.	.	NNP
cord-259603-bh198xgl	63	41	,	,	,
cord-259603-bh198xgl	63	42	2006	2006	CD
cord-259603-bh198xgl	63	43	)	)	-RRB-
cord-259603-bh198xgl	63	44	.	.	.
cord-259603-bh198xgl	64	1	This	this	DT
cord-259603-bh198xgl	64	2	secondary	secondary	JJ
cord-259603-bh198xgl	64	3	function	function	NN
cord-259603-bh198xgl	64	4	has	have	VBZ
cord-259603-bh198xgl	64	5	been	be	VBN
cord-259603-bh198xgl	64	6	implicated	implicate	VBN
cord-259603-bh198xgl	64	7	in	in	IN
cord-259603-bh198xgl	64	8	the	the	DT
cord-259603-bh198xgl	64	9	disruption	disruption	NN
cord-259603-bh198xgl	64	10	of	of	IN
cord-259603-bh198xgl	64	11	host	host	NN
cord-259603-bh198xgl	64	12	innate	innate	JJ
cord-259603-bh198xgl	64	13	immune	immune	JJ
cord-259603-bh198xgl	64	14	signaling	signaling	NN
cord-259603-bh198xgl	64	15	by	by	IN
cord-259603-bh198xgl	64	16	removing	remove	VBG
cord-259603-bh198xgl	64	17	ubiquitin	ubiquitin	NN
cord-259603-bh198xgl	64	18	from	from	IN
cord-259603-bh198xgl	64	19	certain	certain	JJ
cord-259603-bh198xgl	64	20	cellular	cellular	JJ
cord-259603-bh198xgl	64	21	substrates	substrate	NNS
cord-259603-bh198xgl	64	22	.	.	.
cord-259603-bh198xgl	65	1	More	More	JJR
cord-259603-bh198xgl	65	2	than	than	IN
cord-259603-bh198xgl	65	3	any	any	DT
cord-259603-bh198xgl	65	4	other	other	JJ
cord-259603-bh198xgl	65	5	CoV	cov	NN
cord-259603-bh198xgl	65	6	-	-	HYPH
cord-259603-bh198xgl	65	7	encoded	encode	VBN
cord-259603-bh198xgl	65	8	enzyme	enzyme	NN
cord-259603-bh198xgl	65	9	,	,	,
cord-259603-bh198xgl	65	10	the	the	DT
cord-259603-bh198xgl	65	11	CoV	cov	NN
cord-259603-bh198xgl	65	12	3CL	3cl	CD
cord-259603-bh198xgl	65	13	pro	pro	JJ
cord-259603-bh198xgl	65	14	and	and	CC
cord-259603-bh198xgl	65	15	PL	pl	NN
cord-259603-bh198xgl	65	16	pro	pro	JJ
cord-259603-bh198xgl	65	17	domains	domain	NNS
cord-259603-bh198xgl	65	18	have	have	VBP
cord-259603-bh198xgl	65	19	been	be	VBN
cord-259603-bh198xgl	65	20	characterized	characterize	VBN
cord-259603-bh198xgl	65	21	in	in	IN
cord-259603-bh198xgl	65	22	exquisite	exquisite	JJ
cord-259603-bh198xgl	65	23	structural	structural	JJ
cord-259603-bh198xgl	65	24	and	and	CC
cord-259603-bh198xgl	65	25	biochemical	biochemical	JJ
cord-259603-bh198xgl	65	26	detail	detail	NN
cord-259603-bh198xgl	65	27	,	,	,
cord-259603-bh198xgl	65	28	both	both	DT
cord-259603-bh198xgl	65	29	in	in	IN
cord-259603-bh198xgl	65	30	their	-PRON-	PRP$
cord-259603-bh198xgl	65	31	capacity	capacity	NN
cord-259603-bh198xgl	65	32	of	of	IN
cord-259603-bh198xgl	65	33	critical	critical	JJ
cord-259603-bh198xgl	65	34	regulators	regulator	NNS
cord-259603-bh198xgl	65	35	of	of	IN
cord-259603-bh198xgl	65	36	nsp	nsp	NNP
cord-259603-bh198xgl	65	37	synthesis	synthesis	NN
cord-259603-bh198xgl	65	38	and	and	CC
cord-259603-bh198xgl	65	39	as	as	IN
cord-259603-bh198xgl	65	40	two	two	CD
cord-259603-bh198xgl	65	41	of	of	IN
cord-259603-bh198xgl	65	42	the	the	DT
cord-259603-bh198xgl	65	43	primary	primary	JJ
cord-259603-bh198xgl	65	44	drug	drug	NN
cord-259603-bh198xgl	65	45	targets	target	NNS
cord-259603-bh198xgl	65	46	for	for	IN
cord-259603-bh198xgl	65	47	this	this	DT
cord-259603-bh198xgl	65	48	virus	virus	NN
cord-259603-bh198xgl	65	49	family	family	NN
cord-259603-bh198xgl	65	50	.	.	.
cord-259603-bh198xgl	66	1	Space	space	NN
cord-259603-bh198xgl	66	2	limitations	limitation	NNS
cord-259603-bh198xgl	66	3	unfortunately	unfortunately	RB
cord-259603-bh198xgl	66	4	prevent	prevent	VBP
cord-259603-bh198xgl	66	5	us	-PRON-	PRP
cord-259603-bh198xgl	66	6	from	from	IN
cord-259603-bh198xgl	66	7	summarizing	summarize	VBG
cord-259603-bh198xgl	66	8	these	these	DT
cord-259603-bh198xgl	66	9	studies	study	NNS
cord-259603-bh198xgl	66	10	in	in	IN
cord-259603-bh198xgl	66	11	more	more	JJR
cord-259603-bh198xgl	66	12	detail	detail	NN
cord-259603-bh198xgl	66	13	,	,	,
cord-259603-bh198xgl	66	14	but	but	CC
cord-259603-bh198xgl	66	15	a	a	DT
cord-259603-bh198xgl	66	16	variety	variety	NN
cord-259603-bh198xgl	66	17	of	of	IN
cord-259603-bh198xgl	66	18	excellent	excellent	JJ
cord-259603-bh198xgl	66	19	reviews	review	NNS
cord-259603-bh198xgl	66	20	is	be	VBZ
cord-259603-bh198xgl	66	21	available	available	JJ
cord-259603-bh198xgl	66	22	to	to	TO
cord-259603-bh198xgl	66	23	compensate	compensate	VB
cord-259603-bh198xgl	66	24	for	for	IN
cord-259603-bh198xgl	66	25	this	this	DT
cord-259603-bh198xgl	66	26	omission	omission	NN
cord-259603-bh198xgl	66	27	(	(	-LRB-
cord-259603-bh198xgl	66	28	Baez	Baez	NNP
cord-259603-bh198xgl	66	29	-	-	HYPH
cord-259603-bh198xgl	66	30	Santos	Santos	NNP
cord-259603-bh198xgl	66	31	et	et	NNP
cord-259603-bh198xgl	66	32	al	al	NNP
cord-259603-bh198xgl	66	33	.	.	NNP
cord-259603-bh198xgl	66	34	,	,	,
cord-259603-bh198xgl	66	35	2015	2015	CD
cord-259603-bh198xgl	66	36	;	;	:
cord-259603-bh198xgl	66	37	Hilgenfeld	Hilgenfeld	NNP
cord-259603-bh198xgl	66	38	,	,	,
cord-259603-bh198xgl	66	39	2014	2014	CD
cord-259603-bh198xgl	66	40	;	;	:
cord-259603-bh198xgl	66	41	Mielech	Mielech	NNP
cord-259603-bh198xgl	66	42	et	et	NNP
cord-259603-bh198xgl	66	43	al	al	NNP
cord-259603-bh198xgl	66	44	.	.	NNP
cord-259603-bh198xgl	66	45	,	,	,
cord-259603-bh198xgl	66	46	2014	2014	CD
cord-259603-bh198xgl	66	47	;	;	:
cord-259603-bh198xgl	66	48	Steuber	Steuber	NNP
cord-259603-bh198xgl	66	49	and	and	CC
cord-259603-bh198xgl	66	50	Hilgenfeld	Hilgenfeld	NNP
cord-259603-bh198xgl	66	51	,	,	,
cord-259603-bh198xgl	66	52	2010	2010	CD
cord-259603-bh198xgl	66	53	)	)	-RRB-
cord-259603-bh198xgl	66	54	.	.	.
cord-259603-bh198xgl	67	1	Once	once	RB
cord-259603-bh198xgl	67	2	released	release	VBN
cord-259603-bh198xgl	67	3	from	from	IN
cord-259603-bh198xgl	67	4	pp1a	pp1a	NNP
cord-259603-bh198xgl	67	5	and	and	CC
cord-259603-bh198xgl	67	6	pp1ab	pp1ab	NNP
cord-259603-bh198xgl	67	7	,	,	,
cord-259603-bh198xgl	67	8	most	most	JJS
cord-259603-bh198xgl	67	9	CoVs	covs	JJ
cord-259603-bh198xgl	67	10	nsps	nsp	NNS
cord-259603-bh198xgl	67	11	studied	study	VBD
cord-259603-bh198xgl	67	12	thus	thus	RB
cord-259603-bh198xgl	67	13	far	far	RB
cord-259603-bh198xgl	67	14	assemble	assemble	VBP
cord-259603-bh198xgl	67	15	into	into	IN
cord-259603-bh198xgl	67	16	a	a	DT
cord-259603-bh198xgl	67	17	membrane	membrane	NN
cord-259603-bh198xgl	67	18	-	-	HYPH
cord-259603-bh198xgl	67	19	bound	bind	VBN
cord-259603-bh198xgl	67	20	ribonucleoprotein	ribonucleoprotein	NN
cord-259603-bh198xgl	67	21	complex	complex	NN
cord-259603-bh198xgl	67	22	that	that	WDT
cord-259603-bh198xgl	67	23	drives	drive	VBZ
cord-259603-bh198xgl	67	24	the	the	DT
cord-259603-bh198xgl	67	25	synthesis	synthesis	NN
cord-259603-bh198xgl	67	26	of	of	IN
cord-259603-bh198xgl	67	27	different	different	JJ
cord-259603-bh198xgl	67	28	forms	form	NNS
cord-259603-bh198xgl	67	29	of	of	IN
cord-259603-bh198xgl	67	30	viral	viral	JJ
cord-259603-bh198xgl	67	31	RNA	RNA	NNP
cord-259603-bh198xgl	67	32	(	(	-LRB-
cord-259603-bh198xgl	67	33	see	see	VB
cord-259603-bh198xgl	67	34	later	later	RB
cord-259603-bh198xgl	67	35	)	)	-RRB-
cord-259603-bh198xgl	67	36	and	and	CC
cord-259603-bh198xgl	67	37	is	be	VBZ
cord-259603-bh198xgl	67	38	sometimes	sometimes	RB
cord-259603-bh198xgl	67	39	referred	refer	VBN
cord-259603-bh198xgl	67	40	to	to	IN
cord-259603-bh198xgl	67	41	as	as	IN
cord-259603-bh198xgl	67	42	the	the	DT
cord-259603-bh198xgl	67	43	replication	replication	NN
cord-259603-bh198xgl	67	44	and	and	CC
cord-259603-bh198xgl	67	45	transcription	transcription	NN
cord-259603-bh198xgl	67	46	complex	complex	NN
cord-259603-bh198xgl	67	47	(	(	-LRB-
cord-259603-bh198xgl	67	48	RTC	RTC	NNP
cord-259603-bh198xgl	67	49	)	)	-RRB-
cord-259603-bh198xgl	67	50	.	.	.
cord-259603-bh198xgl	68	1	While	while	IN
cord-259603-bh198xgl	68	2	viral	viral	JJ
cord-259603-bh198xgl	68	3	RNA	RNA	NNP
cord-259603-bh198xgl	68	4	production	production	NN
cord-259603-bh198xgl	68	5	takes	take	VBZ
cord-259603-bh198xgl	68	6	off	off	RP
cord-259603-bh198xgl	68	7	,	,	,
cord-259603-bh198xgl	68	8	peculiar	peculiar	JJ
cord-259603-bh198xgl	68	9	convoluted	convoluted	JJ
cord-259603-bh198xgl	68	10	membrane	membrane	NN
cord-259603-bh198xgl	68	11	structures	structure	NNS
cord-259603-bh198xgl	68	12	,	,	,
cord-259603-bh198xgl	68	13	spherules	spherule	NNS
cord-259603-bh198xgl	68	14	tethered	tether	VBN
cord-259603-bh198xgl	68	15	to	to	IN
cord-259603-bh198xgl	68	16	zippered	zippered	JJ
cord-259603-bh198xgl	68	17	endoplasmic	endoplasmic	NN
cord-259603-bh198xgl	68	18	reticulum	reticulum	NN
cord-259603-bh198xgl	68	19	,	,	,
cord-259603-bh198xgl	68	20	and	and	CC
cord-259603-bh198xgl	68	21	doublemembrane	doublemembrane	NNP
cord-259603-bh198xgl	68	22	vesicles	vesicle	NNS
cord-259603-bh198xgl	68	23	begin	begin	VBP
cord-259603-bh198xgl	68	24	to	to	TO
cord-259603-bh198xgl	68	25	accumulate	accumulate	VB
cord-259603-bh198xgl	68	26	in	in	IN
cord-259603-bh198xgl	68	27	CoV	cov	NN
cord-259603-bh198xgl	68	28	-	-	HYPH
cord-259603-bh198xgl	68	29	infected	infect	VBN
cord-259603-bh198xgl	68	30	cells	cell	NNS
cord-259603-bh198xgl	69	1	(	(	-LRB-
cord-259603-bh198xgl	69	2	Gosert	Gosert	NNP
cord-259603-bh198xgl	69	3	et	et	NNP
cord-259603-bh198xgl	69	4	al	al	NNP
cord-259603-bh198xgl	69	5	.	.	NNP
cord-259603-bh198xgl	69	6	,	,	,
cord-259603-bh198xgl	69	7	2002	2002	CD
cord-259603-bh198xgl	69	8	;	;	:
cord-259603-bh198xgl	70	1	Knoops	Knoops	NNP
cord-259603-bh198xgl	70	2	et	et	NNP
cord-259603-bh198xgl	70	3	al	al	NNP
cord-259603-bh198xgl	70	4	.	.	NNP
cord-259603-bh198xgl	70	5	,	,	,
cord-259603-bh198xgl	70	6	2008	2008	CD
cord-259603-bh198xgl	70	7	;	;	:
cord-259603-bh198xgl	70	8	Maier	Maier	NNP
cord-259603-bh198xgl	70	9	et	et	NNP
cord-259603-bh198xgl	70	10	al	al	NNP
cord-259603-bh198xgl	70	11	.	.	NNP
cord-259603-bh198xgl	70	12	,	,	,
cord-259603-bh198xgl	70	13	2013	2013	CD
cord-259603-bh198xgl	70	14	)	)	-RRB-
cord-259603-bh198xgl	70	15	.	.	.
cord-259603-bh198xgl	71	1	As	as	IN
cord-259603-bh198xgl	71	2	for	for	IN
cord-259603-bh198xgl	71	3	other	other	JJ
cord-259603-bh198xgl	71	4	+	+	CC
cord-259603-bh198xgl	71	5	RNA	RNA	NNP
cord-259603-bh198xgl	71	6	viruses	virus	NNS
cord-259603-bh198xgl	71	7	,	,	,
cord-259603-bh198xgl	71	8	they	-PRON-	PRP
cord-259603-bh198xgl	71	9	have	have	VBP
cord-259603-bh198xgl	71	10	been	be	VBN
cord-259603-bh198xgl	71	11	postulated	postulate	VBN
cord-259603-bh198xgl	71	12	to	to	TO
cord-259603-bh198xgl	71	13	serve	serve	VB
cord-259603-bh198xgl	71	14	as	as	IN
cord-259603-bh198xgl	71	15	scaffolds	scaffold	NNS
cord-259603-bh198xgl	71	16	,	,	,
cord-259603-bh198xgl	71	17	or	or	CC
cord-259603-bh198xgl	71	18	perhaps	perhaps	RB
cord-259603-bh198xgl	71	19	even	even	RB
cord-259603-bh198xgl	71	20	suitable	suitable	JJ
cord-259603-bh198xgl	71	21	microenvironments	microenvironment	NNS
cord-259603-bh198xgl	71	22	,	,	,
cord-259603-bh198xgl	71	23	for	for	IN
cord-259603-bh198xgl	71	24	viral	viral	JJ
cord-259603-bh198xgl	71	25	RNA	RNA	NNP
cord-259603-bh198xgl	71	26	synthesis	synthesis	NN
cord-259603-bh198xgl	71	27	.	.	.
cord-259603-bh198xgl	72	1	Nevertheless	nevertheless	RB
cord-259603-bh198xgl	72	2	,	,	,
cord-259603-bh198xgl	72	3	many	many	JJ
cord-259603-bh198xgl	72	4	questions	question	NNS
cord-259603-bh198xgl	72	5	on	on	IN
cord-259603-bh198xgl	72	6	their	-PRON-	PRP$
cord-259603-bh198xgl	72	7	biogenesis	biogenesis	NN
cord-259603-bh198xgl	72	8	and	and	CC
cord-259603-bh198xgl	72	9	function	function	NN
cord-259603-bh198xgl	72	10	remain	remain	VBP
cord-259603-bh198xgl	72	11	to	to	TO
cord-259603-bh198xgl	72	12	be	be	VB
cord-259603-bh198xgl	72	13	answered	answer	VBN
cord-259603-bh198xgl	72	14	,	,	,
cord-259603-bh198xgl	72	15	and	and	CC
cord-259603-bh198xgl	72	16	the	the	DT
cord-259603-bh198xgl	72	17	exact	exact	JJ
cord-259603-bh198xgl	72	18	location	location	NN
cord-259603-bh198xgl	72	19	of	of	IN
cord-259603-bh198xgl	72	20	the	the	DT
cord-259603-bh198xgl	72	21	metabolically	metabolically	RB
cord-259603-bh198xgl	72	22	active	active	JJ
cord-259603-bh198xgl	72	23	RTC	RTC	NNP
cord-259603-bh198xgl	72	24	still	still	RB
cord-259603-bh198xgl	72	25	has	have	VBZ
cord-259603-bh198xgl	72	26	to	to	TO
cord-259603-bh198xgl	72	27	be	be	VB
cord-259603-bh198xgl	72	28	pinpointed	pinpoint	VBN
cord-259603-bh198xgl	72	29	"	"	``
cord-259603-bh198xgl	72	30	beyond	beyond	IN
cord-259603-bh198xgl	72	31	reasonable	reasonable	JJ
cord-259603-bh198xgl	72	32	doubt	doubt	NN
cord-259603-bh198xgl	72	33	"	"	''
cord-259603-bh198xgl	72	34	for	for	IN
cord-259603-bh198xgl	72	35	CoVs	CoVs	NNP
cord-259603-bh198xgl	72	36	and	and	CC
cord-259603-bh198xgl	72	37	other	other	JJ
cord-259603-bh198xgl	72	38	nidoviruses	nidoviruse	NNS
cord-259603-bh198xgl	73	1	(	(	-LRB-
cord-259603-bh198xgl	73	2	Hagemeijer	Hagemeijer	NNP
cord-259603-bh198xgl	73	3	et	et	NNP
cord-259603-bh198xgl	73	4	al	al	NNP
cord-259603-bh198xgl	73	5	.	.	NNP
cord-259603-bh198xgl	73	6	,	,	,
cord-259603-bh198xgl	73	7	2012	2012	CD
cord-259603-bh198xgl	73	8	;	;	:
cord-259603-bh198xgl	73	9	Neuman	Neuman	NNP
cord-259603-bh198xgl	73	10	et	et	NNP
cord-259603-bh198xgl	73	11	al	al	NNP
cord-259603-bh198xgl	73	12	.	.	NNP
cord-259603-bh198xgl	73	13	,	,	,
cord-259603-bh198xgl	73	14	2014a	2014a	CD
cord-259603-bh198xgl	73	15	;	;	:
cord-259603-bh198xgl	73	16	van	van	NNP
cord-259603-bh198xgl	73	17	der	der	NNP
cord-259603-bh198xgl	73	18	Hoeven	Hoeven	NNP
cord-259603-bh198xgl	73	19	et	et	NNP
cord-259603-bh198xgl	73	20	al	al	NNP
cord-259603-bh198xgl	73	21	.	.	NNP
cord-259603-bh198xgl	73	22	,	,	,
cord-259603-bh198xgl	73	23	2016	2016	CD
cord-259603-bh198xgl	73	24	)	)	-RRB-
cord-259603-bh198xgl	73	25	.	.	.
cord-259603-bh198xgl	74	1	Three	three	CD
cord-259603-bh198xgl	74	2	ORF1a	ORF1a	NNP
cord-259603-bh198xgl	74	3	-	-	HYPH
cord-259603-bh198xgl	74	4	encoded	encode	VBN
cord-259603-bh198xgl	74	5	replicase	replicase	NN
cord-259603-bh198xgl	74	6	subunits	subunit	NNS
cord-259603-bh198xgl	74	7	containing	contain	VBG
cord-259603-bh198xgl	74	8	transmembrane	transmembrane	NN
cord-259603-bh198xgl	74	9	domains	domain	NNS
cord-259603-bh198xgl	74	10	(	(	-LRB-
cord-259603-bh198xgl	74	11	nsp3	nsp3	NNS
cord-259603-bh198xgl	74	12	,	,	,
cord-259603-bh198xgl	74	13	nsp4	nsp4	NNP
cord-259603-bh198xgl	74	14	,	,	,
cord-259603-bh198xgl	74	15	and	and	CC
cord-259603-bh198xgl	74	16	nsp6	nsp6	NN
cord-259603-bh198xgl	74	17	;	;	:
cord-259603-bh198xgl	74	18	Fig	Fig	NNP
cord-259603-bh198xgl	74	19	.	.	NNP
cord-259603-bh198xgl	74	20	1	1	LS
cord-259603-bh198xgl	74	21	)	)	-RRB-
cord-259603-bh198xgl	74	22	have	have	VBP
cord-259603-bh198xgl	74	23	been	be	VBN
cord-259603-bh198xgl	74	24	implicated	implicate	VBN
cord-259603-bh198xgl	74	25	in	in	IN
cord-259603-bh198xgl	74	26	the	the	DT
cord-259603-bh198xgl	74	27	formation	formation	NN
cord-259603-bh198xgl	74	28	of	of	IN
cord-259603-bh198xgl	74	29	the	the	DT
cord-259603-bh198xgl	74	30	membrane	membrane	NN
cord-259603-bh198xgl	74	31	structures	structure	NNS
cord-259603-bh198xgl	74	32	that	that	WDT
cord-259603-bh198xgl	74	33	are	be	VBP
cord-259603-bh198xgl	74	34	induced	induce	VBN
cord-259603-bh198xgl	74	35	upon	upon	IN
cord-259603-bh198xgl	74	36	CoV	cov	NN
cord-259603-bh198xgl	74	37	infection	infection	NN
cord-259603-bh198xgl	74	38	and	and	CC
cord-259603-bh198xgl	74	39	with	with	IN
cord-259603-bh198xgl	74	40	which	which	WDT
cord-259603-bh198xgl	74	41	the	the	DT
cord-259603-bh198xgl	74	42	RTC	RTC	NNP
cord-259603-bh198xgl	74	43	is	be	VBZ
cord-259603-bh198xgl	74	44	thought	think	VBN
cord-259603-bh198xgl	74	45	to	to	TO
cord-259603-bh198xgl	74	46	be	be	VB
cord-259603-bh198xgl	74	47	associated	associate	VBN
cord-259603-bh198xgl	75	1	(	(	-LRB-
cord-259603-bh198xgl	75	2	Angelini	Angelini	NNP
cord-259603-bh198xgl	75	3	et	et	NNP
cord-259603-bh198xgl	75	4	al	al	NNP
cord-259603-bh198xgl	75	5	.	.	NNP
cord-259603-bh198xgl	75	6	,	,	,
cord-259603-bh198xgl	75	7	2013	2013	CD
cord-259603-bh198xgl	75	8	;	;	:
cord-259603-bh198xgl	75	9	Hagemeijer	Hagemeijer	NNP
cord-259603-bh198xgl	75	10	et	et	NNP
cord-259603-bh198xgl	75	11	al	al	NNP
cord-259603-bh198xgl	75	12	.	.	NNP
cord-259603-bh198xgl	75	13	,	,	,
cord-259603-bh198xgl	75	14	2014	2014	CD
cord-259603-bh198xgl	75	15	)	)	-RRB-
cord-259603-bh198xgl	75	16	.	.	.
cord-259603-bh198xgl	76	1	In	in	IN
cord-259603-bh198xgl	76	2	addition	addition	NN
cord-259603-bh198xgl	76	3	to	to	IN
cord-259603-bh198xgl	76	4	actively	actively	RB
cord-259603-bh198xgl	76	5	engaging	engage	VBG
cord-259603-bh198xgl	76	6	in	in	IN
cord-259603-bh198xgl	76	7	host	host	NN
cord-259603-bh198xgl	76	8	membrane	membrane	NN
cord-259603-bh198xgl	76	9	remodeling	remodeling	NN
cord-259603-bh198xgl	76	10	,	,	,
cord-259603-bh198xgl	76	11	they	-PRON-	PRP
cord-259603-bh198xgl	76	12	may	may	MD
cord-259603-bh198xgl	76	13	serve	serve	VB
cord-259603-bh198xgl	76	14	as	as	IN
cord-259603-bh198xgl	76	15	membrane	membrane	NN
cord-259603-bh198xgl	76	16	anchors	anchor	NNS
cord-259603-bh198xgl	76	17	for	for	IN
cord-259603-bh198xgl	76	18	the	the	DT
cord-259603-bh198xgl	76	19	RTC	RTC	NNP
cord-259603-bh198xgl	76	20	by	by	IN
cord-259603-bh198xgl	76	21	binding	bind	VBG
cord-259603-bh198xgl	76	22	the	the	DT
cord-259603-bh198xgl	76	23	nsps	nsp	NNS
cord-259603-bh198xgl	76	24	that	that	WDT
cord-259603-bh198xgl	76	25	lack	lack	VBP
cord-259603-bh198xgl	76	26	hydrophobic	hydrophobic	JJ
cord-259603-bh198xgl	76	27	domains	domain	NNS
cord-259603-bh198xgl	76	28	,	,	,
cord-259603-bh198xgl	76	29	like	like	IN
cord-259603-bh198xgl	76	30	all	all	DT
cord-259603-bh198xgl	76	31	of	of	IN
cord-259603-bh198xgl	76	32	the	the	DT
cord-259603-bh198xgl	76	33	ORF1b	ORF1b	NNP
cord-259603-bh198xgl	76	34	-	-	HYPH
cord-259603-bh198xgl	76	35	encoded	encode	VBN
cord-259603-bh198xgl	76	36	enzymes	enzyme	NNS
cord-259603-bh198xgl	76	37	.	.	.
cord-259603-bh198xgl	77	1	For	for	IN
cord-259603-bh198xgl	77	2	more	more	JJR
cord-259603-bh198xgl	77	3	details	detail	NNS
cord-259603-bh198xgl	77	4	,	,	,
cord-259603-bh198xgl	77	5	the	the	DT
cord-259603-bh198xgl	77	6	reader	reader	NN
cord-259603-bh198xgl	77	7	is	be	VBZ
cord-259603-bh198xgl	77	8	referred	refer	VBN
cord-259603-bh198xgl	77	9	to	to	IN
cord-259603-bh198xgl	77	10	the	the	DT
cord-259603-bh198xgl	77	11	numerous	numerous	JJ
cord-259603-bh198xgl	77	12	recent	recent	JJ
cord-259603-bh198xgl	77	13	reviews	review	NNS
cord-259603-bh198xgl	77	14	of	of	IN
cord-259603-bh198xgl	77	15	the	the	DT
cord-259603-bh198xgl	77	16	"	"	``
cord-259603-bh198xgl	77	17	replication	replication	NN
cord-259603-bh198xgl	77	18	organelles	organelle	NNS
cord-259603-bh198xgl	77	19	"	"	''
cord-259603-bh198xgl	77	20	of	of	IN
cord-259603-bh198xgl	77	21	CoVs	CoVs	NNP
cord-259603-bh198xgl	77	22	and	and	CC
cord-259603-bh198xgl	77	23	other	other	JJ
cord-259603-bh198xgl	77	24	+	+	.
cord-259603-bh198xgl	78	1	RNA	RNA	NNP
cord-259603-bh198xgl	78	2	viruses	virus	NNS
cord-259603-bh198xgl	78	3	(	(	-LRB-
cord-259603-bh198xgl	78	4	den	den	NNP
cord-259603-bh198xgl	78	5	Boon	Boon	NNP
cord-259603-bh198xgl	78	6	and	and	CC
cord-259603-bh198xgl	78	7	Ahlquist	Ahlquist	NNP
cord-259603-bh198xgl	78	8	,	,	,
cord-259603-bh198xgl	78	9	2010	2010	CD
cord-259603-bh198xgl	78	10	;	;	.
cord-259603-bh198xgl	79	1	Hagemeijer	Hagemeijer	NNP
cord-259603-bh198xgl	79	2	et	et	NNP
cord-259603-bh198xgl	79	3	al	al	NNP
cord-259603-bh198xgl	79	4	.	.	NNP
cord-259603-bh198xgl	79	5	,	,	,
cord-259603-bh198xgl	79	6	2012	2012	CD
cord-259603-bh198xgl	79	7	;	;	:
cord-259603-bh198xgl	79	8	Neuman	Neuman	NNP
cord-259603-bh198xgl	79	9	et	et	NNP
cord-259603-bh198xgl	79	10	al	al	NNP
cord-259603-bh198xgl	79	11	.	.	NNP
cord-259603-bh198xgl	79	12	,	,	,
cord-259603-bh198xgl	79	13	2014a	2014a	CD
cord-259603-bh198xgl	79	14	;	;	:
cord-259603-bh198xgl	79	15	Romero	Romero	NNP
cord-259603-bh198xgl	79	16	-	-	HYPH
cord-259603-bh198xgl	79	17	Brey	Brey	NNP
cord-259603-bh198xgl	79	18	and	and	CC
cord-259603-bh198xgl	79	19	Bartenschlager	Bartenschlager	NNP
cord-259603-bh198xgl	79	20	,	,	,
cord-259603-bh198xgl	79	21	2016	2016	CD
cord-259603-bh198xgl	79	22	;	;	:
cord-259603-bh198xgl	79	23	van	van	NNP
cord-259603-bh198xgl	79	24	der	der	NNP
cord-259603-bh198xgl	79	25	Hoeven	Hoeven	NNP
cord-259603-bh198xgl	79	26	et	et	NNP
cord-259603-bh198xgl	79	27	al	al	NNP
cord-259603-bh198xgl	79	28	.	.	NNP
cord-259603-bh198xgl	79	29	,	,	,
cord-259603-bh198xgl	79	30	2016	2016	CD
cord-259603-bh198xgl	79	31	;	;	.
cord-259603-bh198xgl	80	1	Xu	Xu	NNP
cord-259603-bh198xgl	80	2	and	and	CC
cord-259603-bh198xgl	80	3	Nagy	Nagy	NNP
cord-259603-bh198xgl	80	4	,	,	,
cord-259603-bh198xgl	80	5	2014	2014	CD
cord-259603-bh198xgl	80	6	)	)	-RRB-
cord-259603-bh198xgl	80	7	.	.	.
cord-259603-bh198xgl	81	1	The	the	DT
cord-259603-bh198xgl	81	2	common	common	JJ
cord-259603-bh198xgl	81	3	ancestry	ancestry	NN
cord-259603-bh198xgl	81	4	of	of	IN
cord-259603-bh198xgl	81	5	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	81	6	replicases	replicases	NNP
cord-259603-bh198xgl	81	7	is	be	VBZ
cord-259603-bh198xgl	81	8	not	not	RB
cord-259603-bh198xgl	81	9	only	only	RB
cord-259603-bh198xgl	81	10	reflected	reflect	VBN
cord-259603-bh198xgl	81	11	in	in	IN
cord-259603-bh198xgl	81	12	their	-PRON-	PRP$
cord-259603-bh198xgl	81	13	conserved	conserve	VBN
cord-259603-bh198xgl	81	14	core	core	NN
cord-259603-bh198xgl	81	15	replicase	replicase	NN
cord-259603-bh198xgl	81	16	domains	domain	NNS
cord-259603-bh198xgl	81	17	but	but	CC
cord-259603-bh198xgl	81	18	also	also	RB
cord-259603-bh198xgl	81	19	in	in	IN
cord-259603-bh198xgl	81	20	the	the	DT
cord-259603-bh198xgl	81	21	synthesis	synthesis	NN
cord-259603-bh198xgl	81	22	of	of	IN
cord-259603-bh198xgl	81	23	subgenomic	subgenomic	NNP
cord-259603-bh198xgl	81	24	(	(	-LRB-
cord-259603-bh198xgl	81	25	sg	sg	NNP
cord-259603-bh198xgl	81	26	)	)	-RRB-
cord-259603-bh198xgl	81	27	mRNAs	mrnas	XX
cord-259603-bh198xgl	81	28	that	that	WDT
cord-259603-bh198xgl	81	29	are	be	VBP
cord-259603-bh198xgl	81	30	used	use	VBN
cord-259603-bh198xgl	81	31	to	to	TO
cord-259603-bh198xgl	81	32	express	express	VB
cord-259603-bh198xgl	81	33	the	the	DT
cord-259603-bh198xgl	81	34	genes	gene	NNS
cord-259603-bh198xgl	81	35	located	locate	VBN
cord-259603-bh198xgl	81	36	downstream	downstream	RB
cord-259603-bh198xgl	81	37	of	of	IN
cord-259603-bh198xgl	81	38	ORF1b	ORF1b	NNP
cord-259603-bh198xgl	82	1	(	(	-LRB-
cord-259603-bh198xgl	82	2	Fig	Fig	NNP
cord-259603-bh198xgl	82	3	.	.	NNP
cord-259603-bh198xgl	82	4	1	1	CD
cord-259603-bh198xgl	82	5	)	)	-RRB-
cord-259603-bh198xgl	82	6	.	.	.
cord-259603-bh198xgl	83	1	Although	although	IN
cord-259603-bh198xgl	83	2	some	some	DT
cord-259603-bh198xgl	83	3	nidoviruses	nidoviruse	NNS
cord-259603-bh198xgl	83	4	(	(	-LRB-
cord-259603-bh198xgl	83	5	e.g.	e.g.	RB
cord-259603-bh198xgl	83	6	,	,	,
cord-259603-bh198xgl	83	7	roniand	roniand	NNP
cord-259603-bh198xgl	83	8	mesoniviruses	mesoniviruses	NNPS
cord-259603-bh198xgl	83	9	)	)	-RRB-
cord-259603-bh198xgl	83	10	have	have	VBP
cord-259603-bh198xgl	83	11	only	only	RB
cord-259603-bh198xgl	83	12	a	a	DT
cord-259603-bh198xgl	83	13	few	few	JJ
cord-259603-bh198xgl	83	14	of	of	IN
cord-259603-bh198xgl	83	15	these	these	DT
cord-259603-bh198xgl	83	16	genes	gene	NNS
cord-259603-bh198xgl	83	17	,	,	,
cord-259603-bh198xgl	83	18	they	-PRON-	PRP
cord-259603-bh198xgl	83	19	are	be	VBP
cord-259603-bh198xgl	83	20	much	much	RB
cord-259603-bh198xgl	83	21	more	more	RBR
cord-259603-bh198xgl	83	22	numerous	numerous	JJ
cord-259603-bh198xgl	83	23	in	in	IN
cord-259603-bh198xgl	83	24	arteriviruses	arteriviruse	NNS
cord-259603-bh198xgl	83	25	and	and	CC
cord-259603-bh198xgl	83	26	CoVs	CoVs	NNP
cord-259603-bh198xgl	83	27	,	,	,
cord-259603-bh198xgl	83	28	their	-PRON-	PRP$
cord-259603-bh198xgl	83	29	number	number	NN
cord-259603-bh198xgl	83	30	going	go	VBG
cord-259603-bh198xgl	83	31	up	up	IN
cord-259603-bh198xgl	83	32	to	to	IN
cord-259603-bh198xgl	83	33	about	about	RB
cord-259603-bh198xgl	83	34	a	a	DT
cord-259603-bh198xgl	83	35	dozen	dozen	NN
cord-259603-bh198xgl	83	36	ORFs	orfs	NN
cord-259603-bh198xgl	83	37	for	for	IN
cord-259603-bh198xgl	83	38	some	some	DT
cord-259603-bh198xgl	83	39	CoVs	CoVs	NNP
cord-259603-bh198xgl	83	40	.	.	.
cord-259603-bh198xgl	84	1	In	in	IN
cord-259603-bh198xgl	84	2	addition	addition	NN
cord-259603-bh198xgl	84	3	to	to	IN
cord-259603-bh198xgl	84	4	the	the	DT
cord-259603-bh198xgl	84	5	standard	standard	JJ
cord-259603-bh198xgl	84	6	set	set	NN
cord-259603-bh198xgl	84	7	of	of	IN
cord-259603-bh198xgl	84	8	four	four	CD
cord-259603-bh198xgl	84	9	CoV	cov	NN
cord-259603-bh198xgl	84	10	structural	structural	JJ
cord-259603-bh198xgl	84	11	protein	protein	NN
cord-259603-bh198xgl	84	12	genes	gene	NNS
cord-259603-bh198xgl	84	13	(	(	-LRB-
cord-259603-bh198xgl	84	14	encoding	encode	VBG
cord-259603-bh198xgl	84	15	the	the	DT
cord-259603-bh198xgl	84	16	spike	spike	NN
cord-259603-bh198xgl	84	17	(	(	-LRB-
cord-259603-bh198xgl	84	18	S	S	NNP
cord-259603-bh198xgl	84	19	)	)	-RRB-
cord-259603-bh198xgl	84	20	,	,	,
cord-259603-bh198xgl	84	21	envelope	envelope	NN
cord-259603-bh198xgl	84	22	(	(	-LRB-
cord-259603-bh198xgl	84	23	E	E	NNP
cord-259603-bh198xgl	84	24	)	)	-RRB-
cord-259603-bh198xgl	84	25	,	,	,
cord-259603-bh198xgl	84	26	membrane	membrane	NN
cord-259603-bh198xgl	84	27	(	(	-LRB-
cord-259603-bh198xgl	84	28	M	M	NNP
cord-259603-bh198xgl	84	29	)	)	-RRB-
cord-259603-bh198xgl	84	30	,	,	,
cord-259603-bh198xgl	84	31	and	and	CC
cord-259603-bh198xgl	84	32	nucleocapsid	nucleocapsid	NN
cord-259603-bh198xgl	84	33	(	(	-LRB-
cord-259603-bh198xgl	84	34	N	N	NNP
cord-259603-bh198xgl	84	35	)	)	-RRB-
cord-259603-bh198xgl	84	36	protein	protein	NN
cord-259603-bh198xgl	84	37	)	)	-RRB-
cord-259603-bh198xgl	84	38	,	,	,
cord-259603-bh198xgl	84	39	genomes	genome	NNS
cord-259603-bh198xgl	84	40	in	in	IN
cord-259603-bh198xgl	84	41	different	different	JJ
cord-259603-bh198xgl	84	42	CoV	cov	NN
cord-259603-bh198xgl	84	43	clusters	cluster	NNS
cord-259603-bh198xgl	84	44	contain	contain	VBP
cord-259603-bh198xgl	84	45	varying	vary	VBG
cord-259603-bh198xgl	84	46	numbers	number	NNS
cord-259603-bh198xgl	84	47	of	of	IN
cord-259603-bh198xgl	84	48	ORFs	orfs	NN
cord-259603-bh198xgl	84	49	encoding	encoding	NN
cord-259603-bh198xgl	84	50	so	so	RB
cord-259603-bh198xgl	84	51	-	-	HYPH
cord-259603-bh198xgl	84	52	called	call	VBN
cord-259603-bh198xgl	84	53	"	"	``
cord-259603-bh198xgl	84	54	accessory	accessory	NN
cord-259603-bh198xgl	84	55	proteins	protein	NNS
cord-259603-bh198xgl	84	56	"	"	''
cord-259603-bh198xgl	84	57	Narayanan	Narayanan	NNP
cord-259603-bh198xgl	84	58	et	et	NNP
cord-259603-bh198xgl	84	59	al	al	NNP
cord-259603-bh198xgl	84	60	.	.	NNP
cord-259603-bh198xgl	84	61	,	,	,
cord-259603-bh198xgl	84	62	2008	2008	CD
cord-259603-bh198xgl	84	63	)	)	-RRB-
cord-259603-bh198xgl	84	64	.	.	.
cord-259603-bh198xgl	85	1	The	the	DT
cord-259603-bh198xgl	85	2	proteins	protein	NNS
cord-259603-bh198xgl	85	3	they	-PRON-	PRP
cord-259603-bh198xgl	85	4	encode	encode	VBP
cord-259603-bh198xgl	85	5	are	be	VBP
cord-259603-bh198xgl	85	6	often	often	RB
cord-259603-bh198xgl	85	7	dispensable	dispensable	JJ
cord-259603-bh198xgl	85	8	for	for	IN
cord-259603-bh198xgl	85	9	the	the	DT
cord-259603-bh198xgl	85	10	basic	basic	JJ
cord-259603-bh198xgl	85	11	replicative	replicative	JJ
cord-259603-bh198xgl	85	12	cycle	cycle	NN
cord-259603-bh198xgl	85	13	in	in	IN
cord-259603-bh198xgl	85	14	cultured	cultured	JJ
cord-259603-bh198xgl	85	15	cells	cell	NNS
cord-259603-bh198xgl	85	16	,	,	,
cord-259603-bh198xgl	85	17	but	but	CC
cord-259603-bh198xgl	85	18	highly	highly	RB
cord-259603-bh198xgl	85	19	relevant	relevant	JJ
cord-259603-bh198xgl	85	20	for	for	IN
cord-259603-bh198xgl	85	21	CoV	cov	NN
cord-259603-bh198xgl	85	22	viability	viability	NN
cord-259603-bh198xgl	85	23	and	and	CC
cord-259603-bh198xgl	85	24	pathogenesis	pathogenesis	NN
cord-259603-bh198xgl	85	25	in	in	IN
cord-259603-bh198xgl	85	26	vivo	vivo	NN
cord-259603-bh198xgl	85	27	,	,	,
cord-259603-bh198xgl	85	28	for	for	IN
cord-259603-bh198xgl	85	29	example	example	NN
cord-259603-bh198xgl	85	30	,	,	,
cord-259603-bh198xgl	85	31	because	because	IN
cord-259603-bh198xgl	85	32	they	-PRON-	PRP
cord-259603-bh198xgl	85	33	enable	enable	VBP
cord-259603-bh198xgl	85	34	the	the	DT
cord-259603-bh198xgl	85	35	virus	virus	NN
cord-259603-bh198xgl	85	36	to	to	TO
cord-259603-bh198xgl	85	37	interfere	interfere	VB
cord-259603-bh198xgl	85	38	with	with	IN
cord-259603-bh198xgl	85	39	the	the	DT
cord-259603-bh198xgl	85	40	host	host	NN
cord-259603-bh198xgl	85	41	's	's	POS
cord-259603-bh198xgl	85	42	immune	immune	JJ
cord-259603-bh198xgl	85	43	response	response	NN
cord-259603-bh198xgl	85	44	.	.	.
cord-259603-bh198xgl	86	1	Most	Most	JJS
cord-259603-bh198xgl	86	2	of	of	IN
cord-259603-bh198xgl	86	3	the	the	DT
cord-259603-bh198xgl	86	4	genes	gene	NNS
cord-259603-bh198xgl	86	5	downstream	downstream	RB
cord-259603-bh198xgl	86	6	of	of	IN
cord-259603-bh198xgl	86	7	ORF1b	ORF1b	NNP
cord-259603-bh198xgl	86	8	are	be	VBP
cord-259603-bh198xgl	86	9	made	make	VBN
cord-259603-bh198xgl	86	10	accessible	accessible	JJ
cord-259603-bh198xgl	86	11	to	to	IN
cord-259603-bh198xgl	86	12	ribosomes	ribosome	NNS
cord-259603-bh198xgl	86	13	by	by	IN
cord-259603-bh198xgl	86	14	positioning	position	VBG
cord-259603-bh198xgl	86	15	them	-PRON-	PRP
cord-259603-bh198xgl	86	16	at	at	IN
cord-259603-bh198xgl	86	17	the	the	DT
cord-259603-bh198xgl	86	18	5	5	CD
cord-259603-bh198xgl	86	19	0	0	CD
cord-259603-bh198xgl	86	20	end	end	NN
cord-259603-bh198xgl	86	21	of	of	IN
cord-259603-bh198xgl	86	22	their	-PRON-	PRP$
cord-259603-bh198xgl	86	23	own	own	JJ
cord-259603-bh198xgl	86	24	sg	sg	NNP
cord-259603-bh198xgl	86	25	transcript	transcript	NN
cord-259603-bh198xgl	86	26	.	.	.
cord-259603-bh198xgl	87	1	Occasionally	occasionally	RB
cord-259603-bh198xgl	87	2	,	,	,
cord-259603-bh198xgl	87	3	two	two	CD
cord-259603-bh198xgl	87	4	or	or	CC
cord-259603-bh198xgl	87	5	even	even	RB
cord-259603-bh198xgl	87	6	three	three	CD
cord-259603-bh198xgl	87	7	genes	gene	NNS
cord-259603-bh198xgl	87	8	are	be	VBP
cord-259603-bh198xgl	87	9	expressed	express	VBN
cord-259603-bh198xgl	87	10	from	from	IN
cord-259603-bh198xgl	87	11	the	the	DT
cord-259603-bh198xgl	87	12	same	same	JJ
cord-259603-bh198xgl	87	13	sg	sg	NNP
cord-259603-bh198xgl	87	14	mRNA	mRNA	NNP
cord-259603-bh198xgl	87	15	,	,	,
cord-259603-bh198xgl	87	16	usually	usually	RB
cord-259603-bh198xgl	87	17	by	by	IN
cord-259603-bh198xgl	87	18	employing	employ	VBG
cord-259603-bh198xgl	87	19	ribosomal	ribosomal	JJ
cord-259603-bh198xgl	87	20	"	"	``
cord-259603-bh198xgl	87	21	leaky	leaky	JJ
cord-259603-bh198xgl	87	22	scanning	scanning	NN
cord-259603-bh198xgl	87	23	"	"	''
cord-259603-bh198xgl	87	24	during	during	IN
cord-259603-bh198xgl	87	25	translation	translation	NN
cord-259603-bh198xgl	87	26	initiation	initiation	NN
cord-259603-bh198xgl	87	27	.	.	.
cord-259603-bh198xgl	88	1	Nidoviral	Nidoviral	NNP
cord-259603-bh198xgl	88	2	sg	sg	NNP
cord-259603-bh198xgl	88	3	mRNAs	mRNAs	NNP
cord-259603-bh198xgl	88	4	are	be	VBP
cord-259603-bh198xgl	88	5	3	3	CD
cord-259603-bh198xgl	89	1	0	0	LS
cord-259603-bh198xgl	89	2	-coterminal	-coterminal	JJ
cord-259603-bh198xgl	89	3	with	with	IN
cord-259603-bh198xgl	89	4	the	the	DT
cord-259603-bh198xgl	89	5	viral	viral	JJ
cord-259603-bh198xgl	89	6	genome	genome	NN
cord-259603-bh198xgl	89	7	,	,	,
cord-259603-bh198xgl	89	8	but	but	CC
cord-259603-bh198xgl	89	9	in	in	IN
cord-259603-bh198xgl	89	10	most	most	JJS
cord-259603-bh198xgl	89	11	nidovirus	nidovirus	NN
cord-259603-bh198xgl	89	12	taxa	taxon	NNS
cord-259603-bh198xgl	89	13	,	,	,
cord-259603-bh198xgl	89	14	including	include	VBG
cord-259603-bh198xgl	89	15	CoVs	CoVs	NNP
cord-259603-bh198xgl	89	16	,	,	,
cord-259603-bh198xgl	89	17	the	the	DT
cord-259603-bh198xgl	89	18	sg	sg	NNP
cord-259603-bh198xgl	89	19	transcripts	transcript	NNS
cord-259603-bh198xgl	89	20	also	also	RB
cord-259603-bh198xgl	89	21	carry	carry	VBP
cord-259603-bh198xgl	89	22	common	common	JJ
cord-259603-bh198xgl	89	23	5	5	CD
cord-259603-bh198xgl	89	24	0	0	CD
cord-259603-bh198xgl	89	25	leader	leader	NN
cord-259603-bh198xgl	89	26	sequences	sequence	NNS
cord-259603-bh198xgl	89	27	(	(	-LRB-
cord-259603-bh198xgl	89	28	$	$	$
cord-259603-bh198xgl	89	29	65	65	CD
cord-259603-bh198xgl	89	30	-	-	SYM
cord-259603-bh198xgl	89	31	95	95	CD
cord-259603-bh198xgl	89	32	nucleotides	nucleotide	NNS
cord-259603-bh198xgl	89	33	in	in	IN
cord-259603-bh198xgl	89	34	CoVs	CoVs	NNP
cord-259603-bh198xgl	89	35	)	)	-RRB-
cord-259603-bh198xgl	89	36	,	,	,
cord-259603-bh198xgl	89	37	which	which	WDT
cord-259603-bh198xgl	89	38	are	be	VBP
cord-259603-bh198xgl	89	39	identical	identical	JJ
cord-259603-bh198xgl	89	40	to	to	IN
cord-259603-bh198xgl	89	41	the	the	DT
cord-259603-bh198xgl	89	42	5	5	CD
cord-259603-bh198xgl	89	43	0	0	CD
cord-259603-bh198xgl	89	44	-terminal	-terminal	JJ
cord-259603-bh198xgl	89	45	sequence	sequence	NN
cord-259603-bh198xgl	89	46	of	of	IN
cord-259603-bh198xgl	89	47	the	the	DT
cord-259603-bh198xgl	89	48	viral	viral	JJ
cord-259603-bh198xgl	89	49	genome	genome	NN
cord-259603-bh198xgl	89	50	(	(	-LRB-
cord-259603-bh198xgl	89	51	Fig	Fig	NNP
cord-259603-bh198xgl	89	52	.	.	.
cord-259603-bh198xgl	89	53	1	1	CD
cord-259603-bh198xgl	89	54	)	)	-RRB-
cord-259603-bh198xgl	90	1	(	(	-LRB-
cord-259603-bh198xgl	90	2	Pasternak	Pasternak	NNP
cord-259603-bh198xgl	90	3	et	et	NNP
cord-259603-bh198xgl	90	4	al	al	NNP
cord-259603-bh198xgl	90	5	.	.	NNP
cord-259603-bh198xgl	90	6	,	,	,
cord-259603-bh198xgl	90	7	2006	2006	CD
cord-259603-bh198xgl	91	1	;	;	:
cord-259603-bh198xgl	91	2	Sawicki	Sawicki	NNP
cord-259603-bh198xgl	91	3	et	et	NNP
cord-259603-bh198xgl	91	4	al	al	NNP
cord-259603-bh198xgl	91	5	.	.	NNP
cord-259603-bh198xgl	91	6	,	,	,
cord-259603-bh198xgl	91	7	2007	2007	CD
cord-259603-bh198xgl	92	1	;	;	:
cord-259603-bh198xgl	92	2	Sola	Sola	NNP
cord-259603-bh198xgl	92	3	et	et	FW
cord-259603-bh198xgl	92	4	al	al	NNP
cord-259603-bh198xgl	92	5	.	.	NNP
cord-259603-bh198xgl	92	6	,	,	,
cord-259603-bh198xgl	92	7	2011	2011	CD
cord-259603-bh198xgl	92	8	)	)	-RRB-
cord-259603-bh198xgl	92	9	.	.	.
cord-259603-bh198xgl	93	1	The	the	DT
cord-259603-bh198xgl	93	2	joining	joining	NN
cord-259603-bh198xgl	93	3	of	of	IN
cord-259603-bh198xgl	93	4	common	common	JJ
cord-259603-bh198xgl	93	5	leader	leader	NN
cord-259603-bh198xgl	93	6	and	and	CC
cord-259603-bh198xgl	93	7	different	different	JJ
cord-259603-bh198xgl	93	8	sg	sg	NNP
cord-259603-bh198xgl	93	9	RNA	RNA	NNP
cord-259603-bh198xgl	93	10	"	"	``
cord-259603-bh198xgl	93	11	body	body	NN
cord-259603-bh198xgl	93	12	"	"	''
cord-259603-bh198xgl	93	13	sequences	sequence	NNS
cord-259603-bh198xgl	93	14	occurs	occur	VBZ
cord-259603-bh198xgl	93	15	during	during	IN
cord-259603-bh198xgl	93	16	minus	minus	JJ
cord-259603-bh198xgl	93	17	-	-	HYPH
cord-259603-bh198xgl	93	18	strand	strand	NN
cord-259603-bh198xgl	93	19	RNA	RNA	NNP
cord-259603-bh198xgl	93	20	synthesis	synthesis	NN
cord-259603-bh198xgl	93	21	(	(	-LRB-
cord-259603-bh198xgl	93	22	Sawicki	Sawicki	NNP
cord-259603-bh198xgl	93	23	and	and	CC
cord-259603-bh198xgl	93	24	Sawicki	Sawicki	NNP
cord-259603-bh198xgl	93	25	,	,	,
cord-259603-bh198xgl	93	26	1995	1995	CD
cord-259603-bh198xgl	93	27	;	;	:
cord-259603-bh198xgl	94	1	Sethna	Sethna	NNP
cord-259603-bh198xgl	94	2	et	et	NNP
cord-259603-bh198xgl	94	3	al	al	NNP
cord-259603-bh198xgl	94	4	.	.	NNP
cord-259603-bh198xgl	94	5	,	,	,
cord-259603-bh198xgl	94	6	1989	1989	CD
cord-259603-bh198xgl	94	7	)	)	-RRB-
cord-259603-bh198xgl	94	8	.	.	.
cord-259603-bh198xgl	95	1	This	this	DT
cord-259603-bh198xgl	95	2	step	step	NN
cord-259603-bh198xgl	95	3	can	can	MD
cord-259603-bh198xgl	95	4	be	be	VB
cord-259603-bh198xgl	95	5	either	either	CC
cord-259603-bh198xgl	95	6	continuous	continuous	JJ
cord-259603-bh198xgl	95	7	,	,	,
cord-259603-bh198xgl	95	8	to	to	TO
cord-259603-bh198xgl	95	9	produce	produce	VB
cord-259603-bh198xgl	95	10	the	the	DT
cord-259603-bh198xgl	95	11	full	full	JJ
cord-259603-bh198xgl	95	12	-	-	HYPH
cord-259603-bh198xgl	95	13	length	length	NN
cord-259603-bh198xgl	96	1	minus	minus	CC
cord-259603-bh198xgl	96	2	strand	strand	NN
cord-259603-bh198xgl	96	3	required	require	VBN
cord-259603-bh198xgl	96	4	for	for	IN
cord-259603-bh198xgl	96	5	genome	genome	NN
cord-259603-bh198xgl	96	6	replication	replication	NN
cord-259603-bh198xgl	96	7	,	,	,
cord-259603-bh198xgl	96	8	or	or	CC
cord-259603-bh198xgl	96	9	interrupted	interrupt	VBN
cord-259603-bh198xgl	96	10	(	(	-LRB-
cord-259603-bh198xgl	96	11	discontinuous	discontinuous	JJ
cord-259603-bh198xgl	96	12	)	)	-RRB-
cord-259603-bh198xgl	96	13	to	to	TO
cord-259603-bh198xgl	96	14	produce	produce	VB
cord-259603-bh198xgl	96	15	a	a	DT
cord-259603-bh198xgl	96	16	subgenome	subgenome	NN
cord-259603-bh198xgl	96	17	-	-	HYPH
cord-259603-bh198xgl	96	18	length	length	NN
cord-259603-bh198xgl	96	19	minus	minus	JJ
cord-259603-bh198xgl	96	20	-	-	HYPH
cord-259603-bh198xgl	96	21	strand	strand	NN
cord-259603-bh198xgl	96	22	RNA	RNA	NNP
cord-259603-bh198xgl	96	23	that	that	WDT
cord-259603-bh198xgl	96	24	can	can	MD
cord-259603-bh198xgl	96	25	subsequently	subsequently	RB
cord-259603-bh198xgl	96	26	serve	serve	VB
cord-259603-bh198xgl	96	27	as	as	IN
cord-259603-bh198xgl	96	28	the	the	DT
cord-259603-bh198xgl	96	29	template	template	NN
cord-259603-bh198xgl	96	30	for	for	IN
cord-259603-bh198xgl	96	31	the	the	DT
cord-259603-bh198xgl	96	32	synthesis	synthesis	NN
cord-259603-bh198xgl	96	33	of	of	IN
cord-259603-bh198xgl	96	34	one	one	CD
cord-259603-bh198xgl	96	35	of	of	IN
cord-259603-bh198xgl	96	36	the	the	DT
cord-259603-bh198xgl	96	37	sg	sg	NNP
cord-259603-bh198xgl	96	38	mRNAs	mRNAs	NNP
cord-259603-bh198xgl	96	39	.	.	.
cord-259603-bh198xgl	97	1	The	the	DT
cord-259603-bh198xgl	97	2	polymerase	polymerase	NN
cord-259603-bh198xgl	97	3	jumping	jumping	NN
cord-259603-bh198xgl	97	4	that	that	WDT
cord-259603-bh198xgl	97	5	is	be	VBZ
cord-259603-bh198xgl	97	6	the	the	DT
cord-259603-bh198xgl	97	7	basis	basis	NN
cord-259603-bh198xgl	97	8	for	for	IN
cord-259603-bh198xgl	97	9	leader	leader	NN
cord-259603-bh198xgl	97	10	-	-	HYPH
cord-259603-bh198xgl	97	11	to	to	IN
cord-259603-bh198xgl	97	12	-	-	HYPH
cord-259603-bh198xgl	97	13	body	body	NN
cord-259603-bh198xgl	97	14	joining	joining	NN
cord-259603-bh198xgl	97	15	occurs	occur	VBZ
cord-259603-bh198xgl	97	16	at	at	IN
cord-259603-bh198xgl	97	17	specific	specific	JJ
cord-259603-bh198xgl	97	18	"	"	``
cord-259603-bh198xgl	97	19	transcriptionregulatory	transcriptionregulatory	NNP
cord-259603-bh198xgl	97	20	sequences	sequence	NNS
cord-259603-bh198xgl	97	21	"	"	''
cord-259603-bh198xgl	97	22	(	(	-LRB-
cord-259603-bh198xgl	97	23	TRSs	TRSs	NNP
cord-259603-bh198xgl	97	24	)	)	-RRB-
cord-259603-bh198xgl	97	25	.	.	.
cord-259603-bh198xgl	98	1	These	these	DT
cord-259603-bh198xgl	98	2	conserved	conserve	VBN
cord-259603-bh198xgl	98	3	sequence	sequence	NN
cord-259603-bh198xgl	98	4	motifs	motif	NNS
cord-259603-bh198xgl	98	5	are	be	VBP
cord-259603-bh198xgl	98	6	comprised	comprise	VBN
cord-259603-bh198xgl	98	7	of	of	IN
cord-259603-bh198xgl	98	8	up	up	IN
cord-259603-bh198xgl	98	9	to	to	IN
cord-259603-bh198xgl	98	10	a	a	DT
cord-259603-bh198xgl	98	11	dozen	dozen	NN
cord-259603-bh198xgl	98	12	nucleotides	nucleotide	NNS
cord-259603-bh198xgl	98	13	,	,	,
cord-259603-bh198xgl	98	14	and	and	CC
cord-259603-bh198xgl	98	15	are	be	VBP
cord-259603-bh198xgl	98	16	found	find	VBN
cord-259603-bh198xgl	98	17	in	in	IN
cord-259603-bh198xgl	98	18	the	the	DT
cord-259603-bh198xgl	98	19	genome	genome	NN
cord-259603-bh198xgl	98	20	at	at	IN
cord-259603-bh198xgl	98	21	the	the	DT
cord-259603-bh198xgl	98	22	3	3	CD
cord-259603-bh198xgl	98	23	0	0	CD
cord-259603-bh198xgl	98	24	end	end	NN
cord-259603-bh198xgl	98	25	of	of	IN
cord-259603-bh198xgl	98	26	the	the	DT
cord-259603-bh198xgl	98	27	leader	leader	NN
cord-259603-bh198xgl	98	28	sequence	sequence	NN
cord-259603-bh198xgl	98	29	and	and	CC
cord-259603-bh198xgl	98	30	at	at	IN
cord-259603-bh198xgl	98	31	the	the	DT
cord-259603-bh198xgl	98	32	5	5	CD
cord-259603-bh198xgl	98	33	0	0	CD
cord-259603-bh198xgl	98	34	end	end	NN
cord-259603-bh198xgl	98	35	of	of	IN
cord-259603-bh198xgl	98	36	each	each	DT
cord-259603-bh198xgl	98	37	of	of	IN
cord-259603-bh198xgl	98	38	the	the	DT
cord-259603-bh198xgl	98	39	sg	sg	NNP
cord-259603-bh198xgl	98	40	mRNA	mRNA	NNP
cord-259603-bh198xgl	98	41	bodies	body	NNS
cord-259603-bh198xgl	98	42	.	.	.
cord-259603-bh198xgl	99	1	Quite	quite	RB
cord-259603-bh198xgl	99	2	likely	likely	RB
cord-259603-bh198xgl	99	3	,	,	,
cord-259603-bh198xgl	99	4	also	also	RB
cord-259603-bh198xgl	99	5	higher	high	JJR
cord-259603-bh198xgl	99	6	-	-	HYPH
cord-259603-bh198xgl	99	7	order	order	NN
cord-259603-bh198xgl	99	8	RNA	RNA	NNP
cord-259603-bh198xgl	99	9	structure	structure	NN
cord-259603-bh198xgl	99	10	and	and	CC
cord-259603-bh198xgl	99	11	transcription	transcription	NN
cord-259603-bh198xgl	99	12	-	-	HYPH
cord-259603-bh198xgl	99	13	specific	specific	JJ
cord-259603-bh198xgl	99	14	protein	protein	NN
cord-259603-bh198xgl	99	15	factors	factor	NNS
cord-259603-bh198xgl	99	16	play	play	VBP
cord-259603-bh198xgl	99	17	a	a	DT
cord-259603-bh198xgl	99	18	role	role	NN
cord-259603-bh198xgl	99	19	in	in	IN
cord-259603-bh198xgl	99	20	the	the	DT
cord-259603-bh198xgl	99	21	interruption	interruption	NN
cord-259603-bh198xgl	99	22	of	of	IN
cord-259603-bh198xgl	99	23	minus	minus	JJ
cord-259603-bh198xgl	99	24	-	-	HYPH
cord-259603-bh198xgl	99	25	strand	strand	NN
cord-259603-bh198xgl	99	26	RNA	RNA	NNP
cord-259603-bh198xgl	99	27	synthesis	synthesis	NN
cord-259603-bh198xgl	99	28	at	at	IN
cord-259603-bh198xgl	99	29	a	a	DT
cord-259603-bh198xgl	99	30	body	body	NN
cord-259603-bh198xgl	99	31	TRS	TRS	NNP
cord-259603-bh198xgl	99	32	,	,	,
cord-259603-bh198xgl	99	33	after	after	IN
cord-259603-bh198xgl	99	34	which	which	WDT
cord-259603-bh198xgl	99	35	the	the	DT
cord-259603-bh198xgl	99	36	nascent	nascent	JJ
cord-259603-bh198xgl	99	37	minus	minus	NN
cord-259603-bh198xgl	99	38	strand	strand	NN
cord-259603-bh198xgl	99	39	(	(	-LRB-
cord-259603-bh198xgl	99	40	with	with	IN
cord-259603-bh198xgl	99	41	a	a	DT
cord-259603-bh198xgl	99	42	body	body	NN
cord-259603-bh198xgl	99	43	TRS	trs	NN
cord-259603-bh198xgl	99	44	complement	complement	NN
cord-259603-bh198xgl	99	45	at	at	IN
cord-259603-bh198xgl	99	46	its	-PRON-	PRP$
cord-259603-bh198xgl	99	47	3	3	CD
cord-259603-bh198xgl	99	48	0	0	CD
cord-259603-bh198xgl	99	49	end	end	NN
cord-259603-bh198xgl	99	50	)	)	-RRB-
cord-259603-bh198xgl	99	51	is	be	VBZ
cord-259603-bh198xgl	99	52	translocated	translocate	VBN
cord-259603-bh198xgl	99	53	to	to	IN
cord-259603-bh198xgl	99	54	the	the	DT
cord-259603-bh198xgl	99	55	5	5	CD
cord-259603-bh198xgl	99	56	0	0	CD
cord-259603-bh198xgl	99	57	-proximal	-proximal	JJS
cord-259603-bh198xgl	99	58	part	part	NN
cord-259603-bh198xgl	99	59	of	of	IN
cord-259603-bh198xgl	99	60	the	the	DT
cord-259603-bh198xgl	99	61	genomic	genomic	JJ
cord-259603-bh198xgl	99	62	template	template	NN
cord-259603-bh198xgl	99	63	.	.	.
cord-259603-bh198xgl	100	1	Guided	guide	VBN
cord-259603-bh198xgl	100	2	by	by	IN
cord-259603-bh198xgl	100	3	a	a	DT
cord-259603-bh198xgl	100	4	base	base	NN
cord-259603-bh198xgl	100	5	-	-	HYPH
cord-259603-bh198xgl	100	6	pairing	pair	VBG
cord-259603-bh198xgl	100	7	interaction	interaction	NN
cord-259603-bh198xgl	100	8	with	with	IN
cord-259603-bh198xgl	100	9	the	the	DT
cord-259603-bh198xgl	100	10	leader	leader	NN
cord-259603-bh198xgl	100	11	TRS	TRS	NNP
cord-259603-bh198xgl	100	12	,	,	,
cord-259603-bh198xgl	100	13	the	the	DT
cord-259603-bh198xgl	100	14	synthesis	synthesis	NN
cord-259603-bh198xgl	100	15	of	of	IN
cord-259603-bh198xgl	100	16	the	the	DT
cord-259603-bh198xgl	100	17	subgenome	subgenome	NN
cord-259603-bh198xgl	100	18	-	-	HYPH
cord-259603-bh198xgl	100	19	length	length	NN
cord-259603-bh198xgl	100	20	minus	minus	JJ
cord-259603-bh198xgl	100	21	-	-	HYPH
cord-259603-bh198xgl	100	22	strand	strand	NN
cord-259603-bh198xgl	100	23	RNA	RNA	NNP
cord-259603-bh198xgl	100	24	is	be	VBZ
cord-259603-bh198xgl	100	25	resumed	resume	VBN
cord-259603-bh198xgl	100	26	and	and	CC
cord-259603-bh198xgl	100	27	completed	complete	VBN
cord-259603-bh198xgl	100	28	with	with	IN
cord-259603-bh198xgl	100	29	the	the	DT
cord-259603-bh198xgl	100	30	addition	addition	NN
cord-259603-bh198xgl	100	31	of	of	IN
cord-259603-bh198xgl	100	32	the	the	DT
cord-259603-bh198xgl	100	33	complement	complement	NN
cord-259603-bh198xgl	100	34	of	of	IN
cord-259603-bh198xgl	100	35	the	the	DT
cord-259603-bh198xgl	100	36	genomic	genomic	JJ
cord-259603-bh198xgl	100	37	leader	leader	NN
cord-259603-bh198xgl	100	38	sequence	sequence	NN
cord-259603-bh198xgl	100	39	.	.	.
cord-259603-bh198xgl	101	1	In	in	IN
cord-259603-bh198xgl	101	2	this	this	DT
cord-259603-bh198xgl	101	3	manner	manner	NN
cord-259603-bh198xgl	101	4	,	,	,
cord-259603-bh198xgl	101	5	a	a	DT
cord-259603-bh198xgl	101	6	nested	nest	VBN
cord-259603-bh198xgl	101	7	set	set	NN
cord-259603-bh198xgl	101	8	of	of	IN
cord-259603-bh198xgl	101	9	subgenome	subgenome	NN
cord-259603-bh198xgl	101	10	-	-	HYPH
cord-259603-bh198xgl	101	11	length	length	NN
cord-259603-bh198xgl	101	12	templates	template	NNS
cord-259603-bh198xgl	101	13	for	for	IN
cord-259603-bh198xgl	101	14	sg	sg	NNP
cord-259603-bh198xgl	101	15	mRNA	mRNA	NNP
cord-259603-bh198xgl	101	16	synthesis	synthesis	NN
cord-259603-bh198xgl	101	17	is	be	VBZ
cord-259603-bh198xgl	101	18	produced	produce	VBN
cord-259603-bh198xgl	101	19	,	,	,
cord-259603-bh198xgl	101	20	providing	provide	VBG
cord-259603-bh198xgl	101	21	a	a	DT
cord-259603-bh198xgl	101	22	mechanism	mechanism	NN
cord-259603-bh198xgl	101	23	to	to	TO
cord-259603-bh198xgl	101	24	regulate	regulate	VB
cord-259603-bh198xgl	101	25	the	the	DT
cord-259603-bh198xgl	101	26	abundance	abundance	NN
cord-259603-bh198xgl	101	27	of	of	IN
cord-259603-bh198xgl	101	28	the	the	DT
cord-259603-bh198xgl	101	29	different	different	JJ
cord-259603-bh198xgl	101	30	viral	viral	JJ
cord-259603-bh198xgl	101	31	proteins	protein	NNS
cord-259603-bh198xgl	101	32	by	by	IN
cord-259603-bh198xgl	101	33	fine	fine	RB
cord-259603-bh198xgl	101	34	-	-	HYPH
cord-259603-bh198xgl	101	35	tuning	tuning	VB
cord-259603-bh198xgl	101	36	the	the	DT
cord-259603-bh198xgl	101	37	level	level	NN
cord-259603-bh198xgl	101	38	at	at	IN
cord-259603-bh198xgl	101	39	which	which	WDT
cord-259603-bh198xgl	101	40	the	the	DT
cord-259603-bh198xgl	101	41	corresponding	correspond	VBG
cord-259603-bh198xgl	101	42	sg	sg	NNP
cord-259603-bh198xgl	101	43	mRNA	mRNA	NNP
cord-259603-bh198xgl	101	44	is	be	VBZ
cord-259603-bh198xgl	101	45	generated	generate	VBN
cord-259603-bh198xgl	101	46	(	(	-LRB-
cord-259603-bh198xgl	101	47	Nedialkova	Nedialkova	NNP
cord-259603-bh198xgl	101	48	et	et	NNP
cord-259603-bh198xgl	101	49	al	al	NNP
cord-259603-bh198xgl	101	50	.	.	NNP
cord-259603-bh198xgl	101	51	,	,	,
cord-259603-bh198xgl	101	52	2010	2010	CD
cord-259603-bh198xgl	101	53	)	)	-RRB-
cord-259603-bh198xgl	101	54	.	.	.
cord-259603-bh198xgl	102	1	The	the	DT
cord-259603-bh198xgl	102	2	CoV	cov	NN
cord-259603-bh198xgl	102	3	transcription	transcription	NN
cord-259603-bh198xgl	102	4	strategy	strategy	NN
cord-259603-bh198xgl	102	5	allows	allow	VBZ
cord-259603-bh198xgl	102	6	the	the	DT
cord-259603-bh198xgl	102	7	RTC	RTC	NNP
cord-259603-bh198xgl	102	8	to	to	TO
cord-259603-bh198xgl	102	9	use	use	VB
cord-259603-bh198xgl	102	10	the	the	DT
cord-259603-bh198xgl	102	11	same	same	JJ
cord-259603-bh198xgl	102	12	3	3	CD
cord-259603-bh198xgl	102	13	0	0	CD
cord-259603-bh198xgl	102	14	-terminal	-terminal	JJ
cord-259603-bh198xgl	102	15	recognition	recognition	NN
cord-259603-bh198xgl	102	16	/	/	SYM
cord-259603-bh198xgl	102	17	initiation	initiation	NN
cord-259603-bh198xgl	102	18	signals	signal	NNS
cord-259603-bh198xgl	102	19	in	in	IN
cord-259603-bh198xgl	102	20	both	both	CC
cord-259603-bh198xgl	102	21	full	full	JJ
cord-259603-bh198xgl	102	22	-	-	HYPH
cord-259603-bh198xgl	102	23	and	and	CC
cord-259603-bh198xgl	102	24	subgenome	subgenome	NN
cord-259603-bh198xgl	102	25	-	-	HYPH
cord-259603-bh198xgl	102	26	length	length	NN
cord-259603-bh198xgl	102	27	templates	template	NNS
cord-259603-bh198xgl	102	28	of	of	IN
cord-259603-bh198xgl	102	29	either	either	DT
cord-259603-bh198xgl	102	30	polarity	polarity	NN
cord-259603-bh198xgl	102	31	.	.	.
cord-259603-bh198xgl	103	1	Moreover	moreover	RB
cord-259603-bh198xgl	103	2	,	,	,
cord-259603-bh198xgl	103	3	the	the	DT
cord-259603-bh198xgl	103	4	presence	presence	NN
cord-259603-bh198xgl	103	5	of	of	IN
cord-259603-bh198xgl	103	6	the	the	DT
cord-259603-bh198xgl	103	7	common	common	JJ
cord-259603-bh198xgl	103	8	5	5	CD
cord-259603-bh198xgl	103	9	0	0	CD
cord-259603-bh198xgl	103	10	leader	leader	NN
cord-259603-bh198xgl	103	11	sequence	sequence	NN
cord-259603-bh198xgl	103	12	may	may	MD
cord-259603-bh198xgl	103	13	be	be	VB
cord-259603-bh198xgl	103	14	important	important	JJ
cord-259603-bh198xgl	103	15	for	for	IN
cord-259603-bh198xgl	103	16	mRNA	mrna	NN
cord-259603-bh198xgl	103	17	capping	cap	VBG
cord-259603-bh198xgl	103	18	or	or	CC
cord-259603-bh198xgl	103	19	other	other	JJ
cord-259603-bh198xgl	103	20	translation	translation	NN
cord-259603-bh198xgl	103	21	-	-	HYPH
cord-259603-bh198xgl	103	22	related	relate	VBN
cord-259603-bh198xgl	103	23	features	feature	NNS
cord-259603-bh198xgl	103	24	.	.	.
cord-259603-bh198xgl	104	1	During	during	IN
cord-259603-bh198xgl	104	2	the	the	DT
cord-259603-bh198xgl	104	3	past	past	JJ
cord-259603-bh198xgl	104	4	two	two	CD
cord-259603-bh198xgl	104	5	decades	decade	NNS
cord-259603-bh198xgl	104	6	,	,	,
cord-259603-bh198xgl	104	7	studies	study	NNS
cord-259603-bh198xgl	104	8	on	on	IN
cord-259603-bh198xgl	104	9	the	the	DT
cord-259603-bh198xgl	104	10	CoV	cov	NN
cord-259603-bh198xgl	104	11	enzyme	enzyme	NN
cord-259603-bh198xgl	104	12	complex	complex	NN
cord-259603-bh198xgl	104	13	that	that	WDT
cord-259603-bh198xgl	104	14	controls	control	VBZ
cord-259603-bh198xgl	104	15	this	this	DT
cord-259603-bh198xgl	104	16	elegant	elegant	JJ
cord-259603-bh198xgl	104	17	replication	replication	NN
cord-259603-bh198xgl	104	18	and	and	CC
cord-259603-bh198xgl	104	19	transcription	transcription	NN
cord-259603-bh198xgl	104	20	mechanism	mechanism	NN
cord-259603-bh198xgl	104	21	have	have	VBP
cord-259603-bh198xgl	104	22	been	be	VBN
cord-259603-bh198xgl	104	23	accelerated	accelerate	VBN
cord-259603-bh198xgl	104	24	by	by	IN
cord-259603-bh198xgl	104	25	four	four	CD
cord-259603-bh198xgl	104	26	important	important	JJ
cord-259603-bh198xgl	104	27	developments	development	NNS
cord-259603-bh198xgl	104	28	.	.	.
cord-259603-bh198xgl	105	1	First	first	RB
cord-259603-bh198xgl	105	2	,	,	,
cord-259603-bh198xgl	105	3	using	use	VBG
cord-259603-bh198xgl	105	4	bioinformatics	bioinformatics	NN
cord-259603-bh198xgl	105	5	,	,	,
cord-259603-bh198xgl	105	6	expression	expression	NN
cord-259603-bh198xgl	105	7	systems	system	NNS
cord-259603-bh198xgl	105	8	,	,	,
cord-259603-bh198xgl	105	9	and	and	CC
cord-259603-bh198xgl	105	10	virus	virus	NN
cord-259603-bh198xgl	105	11	-	-	HYPH
cord-259603-bh198xgl	105	12	infected	infect	VBN
cord-259603-bh198xgl	105	13	cells	cell	NNS
cord-259603-bh198xgl	105	14	,	,	,
cord-259603-bh198xgl	105	15	the	the	DT
cord-259603-bh198xgl	105	16	replicase	replicase	NNP
cord-259603-bh198xgl	105	17	polyprotein	polyprotein	NNP
cord-259603-bh198xgl	105	18	processing	processing	NN
cord-259603-bh198xgl	105	19	scheme	scheme	NN
cord-259603-bh198xgl	105	20	and	and	CC
cord-259603-bh198xgl	105	21	the	the	DT
cord-259603-bh198xgl	105	22	proteases	protease	NNS
cord-259603-bh198xgl	105	23	involved	involve	VBN
cord-259603-bh198xgl	105	24	were	be	VBD
cord-259603-bh198xgl	105	25	elucidated	elucidate	VBN
cord-259603-bh198xgl	105	26	,	,	,
cord-259603-bh198xgl	105	27	thus	thus	RB
cord-259603-bh198xgl	105	28	defining	define	VBG
cord-259603-bh198xgl	105	29	the	the	DT
cord-259603-bh198xgl	105	30	boundaries	boundary	NNS
cord-259603-bh198xgl	105	31	of	of	IN
cord-259603-bh198xgl	105	32	the	the	DT
cord-259603-bh198xgl	105	33	16	16	CD
cord-259603-bh198xgl	105	34	mature	mature	JJ
cord-259603-bh198xgl	105	35	nsps	nsp	NNS
cord-259603-bh198xgl	105	36	(	(	-LRB-
cord-259603-bh198xgl	105	37	Fig	Fig	NNP
cord-259603-bh198xgl	105	38	.	.	.
cord-259603-bh198xgl	105	39	1	1	LS
cord-259603-bh198xgl	105	40	)	)	-RRB-
cord-259603-bh198xgl	105	41	that	that	WDT
cord-259603-bh198xgl	105	42	are	be	VBP
cord-259603-bh198xgl	105	43	working	work	VBG
cord-259603-bh198xgl	105	44	together	together	RB
cord-259603-bh198xgl	105	45	during	during	IN
cord-259603-bh198xgl	105	46	CoV	cov	NN
cord-259603-bh198xgl	105	47	replication	replication	NN
cord-259603-bh198xgl	105	48	(	(	-LRB-
cord-259603-bh198xgl	105	49	Ziebuhr	Ziebuhr	NNP
cord-259603-bh198xgl	105	50	et	et	NNP
cord-259603-bh198xgl	105	51	al	al	NNP
cord-259603-bh198xgl	105	52	.	.	NNP
cord-259603-bh198xgl	105	53	,	,	,
cord-259603-bh198xgl	105	54	2000	2000	CD
cord-259603-bh198xgl	105	55	)	)	-RRB-
cord-259603-bh198xgl	105	56	.	.	.
cord-259603-bh198xgl	106	1	Second	second	RB
cord-259603-bh198xgl	106	2	,	,	,
cord-259603-bh198xgl	106	3	using	use	VBG
cord-259603-bh198xgl	106	4	this	this	DT
cord-259603-bh198xgl	106	5	information	information	NN
cord-259603-bh198xgl	106	6	and	and	CC
cord-259603-bh198xgl	106	7	promoted	promote	VBN
cord-259603-bh198xgl	106	8	by	by	IN
cord-259603-bh198xgl	106	9	rapidly	rapidly	RB
cord-259603-bh198xgl	106	10	advancing	advance	VBG
cord-259603-bh198xgl	106	11	methods	method	NNS
cord-259603-bh198xgl	106	12	in	in	IN
cord-259603-bh198xgl	106	13	structural	structural	JJ
cord-259603-bh198xgl	106	14	biology	biology	NN
cord-259603-bh198xgl	106	15	,	,	,
cord-259603-bh198xgl	106	16	X	x	NN
cord-259603-bh198xgl	106	17	-	-	NN
cord-259603-bh198xgl	106	18	ray	ray	NN
cord-259603-bh198xgl	106	19	or	or	CC
cord-259603-bh198xgl	106	20	NMR	nmr	NN
cord-259603-bh198xgl	106	21	structures	structure	NNS
cord-259603-bh198xgl	106	22	were	be	VBD
cord-259603-bh198xgl	106	23	obtained	obtain	VBN
cord-259603-bh198xgl	106	24	for	for	IN
cord-259603-bh198xgl	106	25	numerous	numerous	JJ
cord-259603-bh198xgl	106	26	(	(	-LRB-
cord-259603-bh198xgl	106	27	recombinant	recombinant	JJ
cord-259603-bh198xgl	106	28	)	)	-RRB-
cord-259603-bh198xgl	106	29	full	full	JJ
cord-259603-bh198xgl	106	30	-	-	HYPH
cord-259603-bh198xgl	106	31	length	length	NN
cord-259603-bh198xgl	106	32	CoV	CoV	NNP
cord-259603-bh198xgl	106	33	nsps	nsps	NNP
cord-259603-bh198xgl	106	34	or	or	CC
cord-259603-bh198xgl	106	35	domains	domain	NNS
cord-259603-bh198xgl	106	36	thereof	thereof	RB
cord-259603-bh198xgl	106	37	,	,	,
cord-259603-bh198xgl	106	38	in	in	IN
cord-259603-bh198xgl	106	39	particular	particular	JJ
cord-259603-bh198xgl	106	40	for	for	IN
cord-259603-bh198xgl	106	41	SARS	SARS	NNP
cord-259603-bh198xgl	106	42	-	-	HYPH
cord-259603-bh198xgl	106	43	CoV	CoV	NNP
cord-259603-bh198xgl	106	44	(	(	-LRB-
cord-259603-bh198xgl	106	45	Neuman	Neuman	NNP
cord-259603-bh198xgl	106	46	et	et	NNP
cord-259603-bh198xgl	106	47	al	al	NNP
cord-259603-bh198xgl	106	48	.	.	NNP
cord-259603-bh198xgl	106	49	,	,	,
cord-259603-bh198xgl	106	50	2014b	2014b	CD
cord-259603-bh198xgl	106	51	)	)	-RRB-
cord-259603-bh198xgl	106	52	.	.	.
cord-259603-bh198xgl	107	1	Third	third	JJ
cord-259603-bh198xgl	107	2	,	,	,
cord-259603-bh198xgl	107	3	multiple	multiple	JJ
cord-259603-bh198xgl	107	4	techniques	technique	NNS
cord-259603-bh198xgl	107	5	for	for	IN
cord-259603-bh198xgl	107	6	the	the	DT
cord-259603-bh198xgl	107	7	targeted	target	VBN
cord-259603-bh198xgl	107	8	mutagenesis	mutagenesis	NN
cord-259603-bh198xgl	107	9	of	of	IN
cord-259603-bh198xgl	107	10	CoV	cov	NN
cord-259603-bh198xgl	107	11	genomes	genome	NNS
cord-259603-bh198xgl	107	12	were	be	VBD
cord-259603-bh198xgl	107	13	developed	develop	VBN
cord-259603-bh198xgl	107	14	and	and	CC
cord-259603-bh198xgl	107	15	refined	refined	JJ
cord-259603-bh198xgl	107	16	,	,	,
cord-259603-bh198xgl	107	17	which	which	WDT
cord-259603-bh198xgl	107	18	was	be	VBD
cord-259603-bh198xgl	107	19	a	a	DT
cord-259603-bh198xgl	107	20	specific	specific	JJ
cord-259603-bh198xgl	107	21	technical	technical	JJ
cord-259603-bh198xgl	107	22	challenge	challenge	NN
cord-259603-bh198xgl	107	23	due	due	IN
cord-259603-bh198xgl	107	24	to	to	IN
cord-259603-bh198xgl	107	25	the	the	DT
cord-259603-bh198xgl	107	26	exceptionally	exceptionally	RB
cord-259603-bh198xgl	107	27	large	large	JJ
cord-259603-bh198xgl	107	28	size	size	NN
cord-259603-bh198xgl	107	29	of	of	IN
cord-259603-bh198xgl	107	30	the	the	DT
cord-259603-bh198xgl	107	31	CoV	CoV	NNP
cord-259603-bh198xgl	107	32	RNA	RNA	NNP
cord-259603-bh198xgl	107	33	genome	genome	NNP
cord-259603-bh198xgl	108	1	(	(	-LRB-
cord-259603-bh198xgl	108	2	Almazan	Almazan	NNP
cord-259603-bh198xgl	108	3	et	et	NNP
cord-259603-bh198xgl	108	4	al	al	NNP
cord-259603-bh198xgl	108	5	.	.	NNP
cord-259603-bh198xgl	108	6	,	,	,
cord-259603-bh198xgl	108	7	2014	2014	CD
cord-259603-bh198xgl	108	8	)	)	-RRB-
cord-259603-bh198xgl	108	9	.	.	.
cord-259603-bh198xgl	109	1	By	by	IN
cord-259603-bh198xgl	109	2	launching	launch	VBG
cord-259603-bh198xgl	109	3	engineered	engineer	VBN
cord-259603-bh198xgl	109	4	mutant	mutant	JJ
cord-259603-bh198xgl	109	5	genomes	genome	NNS
cord-259603-bh198xgl	109	6	in	in	IN
cord-259603-bh198xgl	109	7	susceptible	susceptible	JJ
cord-259603-bh198xgl	109	8	cells	cell	NNS
cord-259603-bh198xgl	109	9	,	,	,
cord-259603-bh198xgl	109	10	the	the	DT
cord-259603-bh198xgl	109	11	RNA	RNA	NNP
cord-259603-bh198xgl	109	12	and	and	CC
cord-259603-bh198xgl	109	13	protein	protein	NN
cord-259603-bh198xgl	109	14	players	player	NNS
cord-259603-bh198xgl	109	15	in	in	IN
cord-259603-bh198xgl	109	16	the	the	DT
cord-259603-bh198xgl	109	17	CoV	cov	NN
cord-259603-bh198xgl	109	18	replication	replication	NN
cord-259603-bh198xgl	109	19	cycle	cycle	NN
cord-259603-bh198xgl	109	20	can	can	MD
cord-259603-bh198xgl	109	21	now	now	RB
cord-259603-bh198xgl	109	22	be	be	VB
cord-259603-bh198xgl	109	23	interrogated	interrogate	VBN
cord-259603-bh198xgl	109	24	directly	directly	RB
cord-259603-bh198xgl	109	25	,	,	,
cord-259603-bh198xgl	109	26	to	to	TO
cord-259603-bh198xgl	109	27	reveal	reveal	VB
cord-259603-bh198xgl	109	28	their	-PRON-	PRP$
cord-259603-bh198xgl	109	29	importance	importance	NN
cord-259603-bh198xgl	109	30	,	,	.
cord-259603-bh198xgl	110	1	function(s	function(s	NNP
cord-259603-bh198xgl	110	2	)	)	-RRB-
cord-259603-bh198xgl	110	3	and/or	and/or	CC
cord-259603-bh198xgl	110	4	interactions	interaction	NNS
cord-259603-bh198xgl	110	5	in	in	IN
cord-259603-bh198xgl	110	6	vivo	vivo	NN
cord-259603-bh198xgl	110	7	.	.	.
cord-259603-bh198xgl	111	1	Finally	finally	RB
cord-259603-bh198xgl	111	2	,	,	,
cord-259603-bh198xgl	111	3	in	in	IN
cord-259603-bh198xgl	111	4	vitro	vitro	FW
cord-259603-bh198xgl	111	5	biochemical	biochemical	JJ
cord-259603-bh198xgl	111	6	assays	assay	NNS
cord-259603-bh198xgl	111	7	were	be	VBD
cord-259603-bh198xgl	111	8	developed	develop	VBN
cord-259603-bh198xgl	111	9	for	for	IN
cord-259603-bh198xgl	111	10	a	a	DT
cord-259603-bh198xgl	111	11	variety	variety	NN
cord-259603-bh198xgl	111	12	of	of	IN
cord-259603-bh198xgl	111	13	CoV	cov	NN
cord-259603-bh198xgl	111	14	replicative	replicative	JJ
cord-259603-bh198xgl	111	15	enzymes	enzyme	NNS
cord-259603-bh198xgl	111	16	,	,	,
cord-259603-bh198xgl	111	17	including	include	VBG
cord-259603-bh198xgl	111	18	many	many	JJ
cord-259603-bh198xgl	111	19	of	of	IN
cord-259603-bh198xgl	111	20	those	those	DT
cord-259603-bh198xgl	111	21	involved	involve	VBN
cord-259603-bh198xgl	111	22	in	in	IN
cord-259603-bh198xgl	111	23	RNA	RNA	NNP
cord-259603-bh198xgl	111	24	synthesis	synthesis	NN
cord-259603-bh198xgl	111	25	and	and	CC
cord-259603-bh198xgl	111	26	processing	processing	NN
cord-259603-bh198xgl	111	27	.	.	.
cord-259603-bh198xgl	112	1	For	for	IN
cord-259603-bh198xgl	112	2	the	the	DT
cord-259603-bh198xgl	112	3	purpose	purpose	NN
cord-259603-bh198xgl	112	4	of	of	IN
cord-259603-bh198xgl	112	5	this	this	DT
cord-259603-bh198xgl	112	6	review	review	NN
cord-259603-bh198xgl	112	7	,	,	,
cord-259603-bh198xgl	112	8	we	-PRON-	PRP
cord-259603-bh198xgl	112	9	have	have	VBP
cord-259603-bh198xgl	112	10	chosen	choose	VBN
cord-259603-bh198xgl	112	11	to	to	TO
cord-259603-bh198xgl	112	12	focus	focus	VB
cord-259603-bh198xgl	112	13	on	on	IN
cord-259603-bh198xgl	112	14	these	these	DT
cord-259603-bh198xgl	112	15	latter	latter	JJ
cord-259603-bh198xgl	112	16	functions	function	NNS
cord-259603-bh198xgl	112	17	,	,	,
cord-259603-bh198xgl	112	18	as	as	IN
cord-259603-bh198xgl	112	19	performed	perform	VBN
cord-259603-bh198xgl	112	20	by	by	IN
cord-259603-bh198xgl	112	21	the	the	DT
cord-259603-bh198xgl	112	22	CoV	cov	NN
cord-259603-bh198xgl	112	23	nsp7	nsp7	NN
cord-259603-bh198xgl	112	24	to	to	IN
cord-259603-bh198xgl	112	25	nsp16	nsp16	NNS
cord-259603-bh198xgl	112	26	products	product	NNS
cord-259603-bh198xgl	112	27	Nga	Nga	NNP
cord-259603-bh198xgl	112	28	et	et	NNP
cord-259603-bh198xgl	112	29	al	al	NNP
cord-259603-bh198xgl	112	30	.	.	NNP
cord-259603-bh198xgl	112	31	,	,	,
cord-259603-bh198xgl	112	32	2011	2011	CD
cord-259603-bh198xgl	112	33	;	;	:
cord-259603-bh198xgl	112	34	Sevajol	Sevajol	NNP
cord-259603-bh198xgl	112	35	et	et	NNP
cord-259603-bh198xgl	112	36	al	al	NNP
cord-259603-bh198xgl	112	37	.	.	NNP
cord-259603-bh198xgl	112	38	,	,	,
cord-259603-bh198xgl	112	39	2014	2014	CD
cord-259603-bh198xgl	112	40	;	;	.
cord-259603-bh198xgl	113	1	Subissi	Subissi	NNP
cord-259603-bh198xgl	113	2	et	et	NNP
cord-259603-bh198xgl	113	3	al	al	NNP
cord-259603-bh198xgl	113	4	.	.	NNP
cord-259603-bh198xgl	113	5	,	,	,
cord-259603-bh198xgl	113	6	2014a	2014a	CD
cord-259603-bh198xgl	113	7	)	)	-RRB-
cord-259603-bh198xgl	113	8	.	.	.
cord-259603-bh198xgl	114	1	These	these	DT
cord-259603-bh198xgl	114	2	subunits	subunit	NNS
cord-259603-bh198xgl	114	3	include	include	VBP
cord-259603-bh198xgl	114	4	several	several	JJ
cord-259603-bh198xgl	114	5	replicative	replicative	JJ
cord-259603-bh198xgl	114	6	enzymes	enzyme	NNS
cord-259603-bh198xgl	114	7	that	that	WDT
cord-259603-bh198xgl	114	8	are	be	VBP
cord-259603-bh198xgl	114	9	more	more	RBR
cord-259603-bh198xgl	114	10	or	or	CC
cord-259603-bh198xgl	114	11	less	less	RBR
cord-259603-bh198xgl	114	12	universal	universal	JJ
cord-259603-bh198xgl	114	13	among	among	IN
cord-259603-bh198xgl	114	14	+	+	CC
cord-259603-bh198xgl	114	15	RNA	RNA	NNP
cord-259603-bh198xgl	114	16	viruses	virus	NNS
cord-259603-bh198xgl	114	17	,	,	,
cord-259603-bh198xgl	114	18	such	such	JJ
cord-259603-bh198xgl	114	19	as	as	IN
cord-259603-bh198xgl	114	20	RNA	RNA	NNP
cord-259603-bh198xgl	114	21	polymerase	polymerase	NN
cord-259603-bh198xgl	114	22	(	(	-LRB-
cord-259603-bh198xgl	114	23	nsp12	nsp12	CD
cord-259603-bh198xgl	114	24	)	)	-RRB-
cord-259603-bh198xgl	114	25	and	and	CC
cord-259603-bh198xgl	114	26	helicase	helicase	NNP
cord-259603-bh198xgl	114	27	(	(	-LRB-
cord-259603-bh198xgl	114	28	nsp13	nsp13	NNP
cord-259603-bh198xgl	114	29	)	)	-RRB-
cord-259603-bh198xgl	114	30	,	,	.
cord-259603-bh198xgl	115	1	but	but	CC
cord-259603-bh198xgl	115	2	also	also	RB
cord-259603-bh198xgl	115	3	a	a	DT
cord-259603-bh198xgl	115	4	number	number	NN
cord-259603-bh198xgl	115	5	of	of	IN
cord-259603-bh198xgl	115	6	rare	rare	JJ
cord-259603-bh198xgl	115	7	or	or	CC
cord-259603-bh198xgl	115	8	even	even	RB
cord-259603-bh198xgl	115	9	unique	unique	JJ
cord-259603-bh198xgl	115	10	domains	domain	NNS
cord-259603-bh198xgl	115	11	involved	involve	VBN
cord-259603-bh198xgl	115	12	in	in	IN
cord-259603-bh198xgl	115	13	,	,	,
cord-259603-bh198xgl	115	14	e.g.	e.g.	RB
cord-259603-bh198xgl	115	15	,	,	,
cord-259603-bh198xgl	115	16	mRNA	mrna	NN
cord-259603-bh198xgl	115	17	capping	capping	NN
cord-259603-bh198xgl	115	18	,	,	,
cord-259603-bh198xgl	115	19	cap	cap	NN
cord-259603-bh198xgl	115	20	modification	modification	NN
cord-259603-bh198xgl	115	21	,	,	,
cord-259603-bh198xgl	115	22	and	and	CC
cord-259603-bh198xgl	115	23	promoting	promote	VBG
cord-259603-bh198xgl	115	24	the	the	DT
cord-259603-bh198xgl	115	25	fidelity	fidelity	NNP
cord-259603-bh198xgl	115	26	of	of	IN
cord-259603-bh198xgl	115	27	CoV	CoV	NNP
cord-259603-bh198xgl	115	28	RNA	RNA	NNP
cord-259603-bh198xgl	115	29	synthesis	synthesis	NN
cord-259603-bh198xgl	115	30	.	.	.
cord-259603-bh198xgl	116	1	Several	several	JJ
cord-259603-bh198xgl	116	2	smaller	small	JJR
cord-259603-bh198xgl	116	3	subunits	subunit	NNS
cord-259603-bh198xgl	116	4	,	,	,
cord-259603-bh198xgl	116	5	in	in	IN
cord-259603-bh198xgl	116	6	particular	particular	JJ
cord-259603-bh198xgl	116	7	nsp7	nsp7	NN
cord-259603-bh198xgl	116	8	to	to	IN
cord-259603-bh198xgl	116	9	nsp10	nsp10	NNP
cord-259603-bh198xgl	116	10	,	,	,
cord-259603-bh198xgl	116	11	have	have	VBP
cord-259603-bh198xgl	116	12	been	be	VBN
cord-259603-bh198xgl	116	13	identified	identify	VBN
cord-259603-bh198xgl	116	14	as	as	IN
cord-259603-bh198xgl	116	15	crucial	crucial	JJ
cord-259603-bh198xgl	116	16	cofactors	cofactor	NNS
cord-259603-bh198xgl	116	17	of	of	IN
cord-259603-bh198xgl	116	18	these	these	DT
cord-259603-bh198xgl	116	19	enzymes	enzyme	NNS
cord-259603-bh198xgl	116	20	and	and	CC
cord-259603-bh198xgl	116	21	contribute	contribute	VBP
cord-259603-bh198xgl	116	22	to	to	IN
cord-259603-bh198xgl	116	23	the	the	DT
cord-259603-bh198xgl	116	24	emerging	emerge	VBG
cord-259603-bh198xgl	116	25	CoV	cov	NN
cord-259603-bh198xgl	116	26	"	"	``
cord-259603-bh198xgl	116	27	nsp	nsp	NNP
cord-259603-bh198xgl	116	28	interactome	interactome	NNP
cord-259603-bh198xgl	116	29	,	,	,
cord-259603-bh198xgl	116	30	"	"	''
cord-259603-bh198xgl	116	31	which	which	WDT
cord-259603-bh198xgl	116	32	will	will	MD
cord-259603-bh198xgl	116	33	likely	likely	RB
cord-259603-bh198xgl	116	34	need	need	VB
cord-259603-bh198xgl	116	35	to	to	TO
cord-259603-bh198xgl	116	36	be	be	VB
cord-259603-bh198xgl	116	37	advanced	advance	VBN
cord-259603-bh198xgl	116	38	considerably	considerably	RB
cord-259603-bh198xgl	116	39	to	to	TO
cord-259603-bh198xgl	116	40	achieve	achieve	VB
cord-259603-bh198xgl	116	41	a	a	DT
cord-259603-bh198xgl	116	42	more	more	RBR
cord-259603-bh198xgl	116	43	complete	complete	JJ
cord-259603-bh198xgl	116	44	understanding	understanding	NN
cord-259603-bh198xgl	116	45	of	of	IN
cord-259603-bh198xgl	116	46	the	the	DT
cord-259603-bh198xgl	116	47	intricacies	intricacy	NNS
cord-259603-bh198xgl	116	48	of	of	IN
cord-259603-bh198xgl	116	49	CoV	CoV	NNP
cord-259603-bh198xgl	116	50	RNA	RNA	NNP
cord-259603-bh198xgl	116	51	synthesis	synthesis	NN
cord-259603-bh198xgl	116	52	.	.	.
cord-259603-bh198xgl	117	1	Making	make	VBG
cord-259603-bh198xgl	117	2	that	that	DT
cord-259603-bh198xgl	117	3	step	step	NN
cord-259603-bh198xgl	117	4	will	will	MD
cord-259603-bh198xgl	117	5	obviously	obviously	RB
cord-259603-bh198xgl	117	6	be	be	VB
cord-259603-bh198xgl	117	7	key	key	JJ
cord-259603-bh198xgl	117	8	to	to	IN
cord-259603-bh198xgl	117	9	understanding	understand	VBG
cord-259603-bh198xgl	117	10	the	the	DT
cord-259603-bh198xgl	117	11	evolutionary	evolutionary	JJ
cord-259603-bh198xgl	117	12	success	success	NN
cord-259603-bh198xgl	117	13	of	of	IN
cord-259603-bh198xgl	117	14	CoVs	CoVs	NNP
cord-259603-bh198xgl	117	15	,	,	,
cord-259603-bh198xgl	117	16	and	and	CC
cord-259603-bh198xgl	117	17	nidoviruses	nidoviruse	VBZ
cord-259603-bh198xgl	117	18	at	at	IN
cord-259603-bh198xgl	117	19	large	large	JJ
cord-259603-bh198xgl	117	20	.	.	.
cord-259603-bh198xgl	118	1	Moreover	moreover	RB
cord-259603-bh198xgl	118	2	,	,	,
cord-259603-bh198xgl	118	3	this	this	DT
cord-259603-bh198xgl	118	4	knowledge	knowledge	NN
cord-259603-bh198xgl	118	5	will	will	MD
cord-259603-bh198xgl	118	6	lay	lay	VB
cord-259603-bh198xgl	118	7	the	the	DT
cord-259603-bh198xgl	118	8	foundation	foundation	NN
cord-259603-bh198xgl	118	9	for	for	IN
cord-259603-bh198xgl	118	10	the	the	DT
cord-259603-bh198xgl	118	11	development	development	NN
cord-259603-bh198xgl	118	12	of	of	IN
cord-259603-bh198xgl	118	13	improved	improved	JJ
cord-259603-bh198xgl	118	14	strategies	strategy	NNS
cord-259603-bh198xgl	118	15	to	to	TO
cord-259603-bh198xgl	118	16	combat	combat	VB
cord-259603-bh198xgl	118	17	current	current	JJ
cord-259603-bh198xgl	118	18	and	and	CC
cord-259603-bh198xgl	118	19	future	future	JJ
cord-259603-bh198xgl	118	20	emerging	emerge	VBG
cord-259603-bh198xgl	118	21	CoVs	CoVs	NNP
cord-259603-bh198xgl	118	22	,	,	,
cord-259603-bh198xgl	118	23	including	include	VBG
cord-259603-bh198xgl	118	24	targeted	target	VBN
cord-259603-bh198xgl	118	25	antiviral	antiviral	JJ
cord-259603-bh198xgl	118	26	drug	drug	NN
cord-259603-bh198xgl	118	27	development	development	NN
cord-259603-bh198xgl	118	28	.	.	.
cord-259603-bh198xgl	119	1	2	2	LS
cord-259603-bh198xgl	119	2	.	.	.
cord-259603-bh198xgl	120	1	CORONAVIRUS	CORONAVIRUS	NNP
cord-259603-bh198xgl	120	2	nsp7	nsp7	NNP
cord-259603-bh198xgl	120	3	-	-	HYPH
cord-259603-bh198xgl	120	4	10	10	CD
cord-259603-bh198xgl	120	5	:	:	:
cord-259603-bh198xgl	120	6	SMALL	small	JJ
cord-259603-bh198xgl	120	7	BUT	but	CC
cord-259603-bh198xgl	120	8	CRITICAL	critical	JJ
cord-259603-bh198xgl	120	9	REGULATORY	regulatory	JJ
cord-259603-bh198xgl	120	10	SUBUNITS	subunit	NNS
cord-259603-bh198xgl	120	11	?	?	.
cord-259603-bh198xgl	121	1	The	the	DT
cord-259603-bh198xgl	121	2	3	3	CD
cord-259603-bh198xgl	121	3	0	0	CD
cord-259603-bh198xgl	121	4	-terminal	-terminal	JJ
cord-259603-bh198xgl	121	5	part	part	NN
cord-259603-bh198xgl	121	6	of	of	IN
cord-259603-bh198xgl	121	7	ORF1a	ORF1a	NNP
cord-259603-bh198xgl	121	8	,	,	,
cord-259603-bh198xgl	121	9	the	the	DT
cord-259603-bh198xgl	121	10	approximately	approximately	RB
cord-259603-bh198xgl	121	11	1.7	1.7	CD
cord-259603-bh198xgl	121	12	kb	kb	NNS
cord-259603-bh198xgl	121	13	separating	separate	VBG
cord-259603-bh198xgl	121	14	the	the	DT
cord-259603-bh198xgl	121	15	nsp6-coding	nsp6-code	VBG
cord-259603-bh198xgl	121	16	sequence	sequence	NN
cord-259603-bh198xgl	121	17	and	and	CC
cord-259603-bh198xgl	121	18	the	the	DT
cord-259603-bh198xgl	121	19	ORF1a/1b	ORF1a/1b	NNP
cord-259603-bh198xgl	121	20	ribosomal	ribosomal	JJ
cord-259603-bh198xgl	121	21	frameshift	frameshift	NN
cord-259603-bh198xgl	121	22	site	site	NN
cord-259603-bh198xgl	121	23	,	,	,
cord-259603-bh198xgl	121	24	encodes	encode	VBZ
cord-259603-bh198xgl	121	25	a	a	DT
cord-259603-bh198xgl	121	26	set	set	NN
cord-259603-bh198xgl	121	27	of	of	IN
cord-259603-bh198xgl	121	28	four	four	CD
cord-259603-bh198xgl	121	29	small	small	JJ
cord-259603-bh198xgl	121	30	replicase	replicase	NN
cord-259603-bh198xgl	121	31	subunits	subunit	NNS
cord-259603-bh198xgl	121	32	,	,	,
cord-259603-bh198xgl	121	33	named	name	VBN
cord-259603-bh198xgl	121	34	nsp7	nsp7	NN
cord-259603-bh198xgl	121	35	to	to	IN
cord-259603-bh198xgl	121	36	nsp10	nsp10	NNP
cord-259603-bh198xgl	121	37	(	(	-LRB-
cord-259603-bh198xgl	121	38	Fig	fig	NN
cord-259603-bh198xgl	121	39	.	.	.
cord-259603-bh198xgl	121	40	1	1	CD
cord-259603-bh198xgl	121	41	)	)	-RRB-
cord-259603-bh198xgl	121	42	.	.	.
cord-259603-bh198xgl	122	1	Although	although	IN
cord-259603-bh198xgl	122	2	highly	highly	RB
cord-259603-bh198xgl	122	3	conserved	conserve	VBN
cord-259603-bh198xgl	122	4	among	among	IN
cord-259603-bh198xgl	122	5	Coronavirinae	Coronavirinae	NNP
cord-259603-bh198xgl	122	6	,	,	,
cord-259603-bh198xgl	122	7	these	these	DT
cord-259603-bh198xgl	122	8	proteins	protein	NNS
cord-259603-bh198xgl	122	9	seem	seem	VBP
cord-259603-bh198xgl	122	10	to	to	TO
cord-259603-bh198xgl	122	11	lack	lack	VB
cord-259603-bh198xgl	122	12	enzymatic	enzymatic	JJ
cord-259603-bh198xgl	122	13	functions	function	NNS
cord-259603-bh198xgl	122	14	.	.	.
cord-259603-bh198xgl	123	1	Instead	instead	RB
cord-259603-bh198xgl	123	2	,	,	,
cord-259603-bh198xgl	123	3	they	-PRON-	PRP
cord-259603-bh198xgl	123	4	have	have	VBP
cord-259603-bh198xgl	123	5	emerged	emerge	VBN
cord-259603-bh198xgl	123	6	as	as	IN
cord-259603-bh198xgl	123	7	(	(	-LRB-
cord-259603-bh198xgl	123	8	putative	putative	JJ
cord-259603-bh198xgl	123	9	)	)	-RRB-
cord-259603-bh198xgl	123	10	interaction	interaction	NN
cord-259603-bh198xgl	123	11	partners	partner	NNS
cord-259603-bh198xgl	123	12	and	and	CC
cord-259603-bh198xgl	123	13	modulators	modulator	NNS
cord-259603-bh198xgl	123	14	of	of	IN
cord-259603-bh198xgl	123	15	ORF1b	ORF1b	NNP
cord-259603-bh198xgl	123	16	-	-	HYPH
cord-259603-bh198xgl	123	17	encoded	encode	VBN
cord-259603-bh198xgl	123	18	core	core	NN
cord-259603-bh198xgl	123	19	enzymes	enzyme	NNS
cord-259603-bh198xgl	123	20	like	like	IN
cord-259603-bh198xgl	123	21	nsp12	nsp12	NNP
cord-259603-bh198xgl	123	22	(	(	-LRB-
cord-259603-bh198xgl	123	23	RNA	RNA	NNP
cord-259603-bh198xgl	123	24	-	-	HYPH
cord-259603-bh198xgl	123	25	dependent	dependent	JJ
cord-259603-bh198xgl	123	26	RNA	RNA	NNP
cord-259603-bh198xgl	123	27	polymerase	polymerase	NN
cord-259603-bh198xgl	123	28	,	,	,
cord-259603-bh198xgl	123	29	RdRp	RdRp	NNP
cord-259603-bh198xgl	123	30	)	)	-RRB-
cord-259603-bh198xgl	123	31	,	,	.
cord-259603-bh198xgl	124	1	nsp14	nsp14	XX
cord-259603-bh198xgl	125	1	(	(	-LRB-
cord-259603-bh198xgl	125	2	exoribonuclease	exoribonuclease	UH
cord-259603-bh198xgl	125	3	,	,	,
cord-259603-bh198xgl	125	4	ExoN	ExoN	NNP
cord-259603-bh198xgl	125	5	)	)	-RRB-
cord-259603-bh198xgl	125	6	,	,	,
cord-259603-bh198xgl	125	7	and	and	CC
cord-259603-bh198xgl	125	8	nsp16	nsp16	NNS
cord-259603-bh198xgl	125	9	(	(	-LRB-
cord-259603-bh198xgl	125	10	ribose	ribose	NN
cord-259603-bh198xgl	125	11	2	2	CD
cord-259603-bh198xgl	125	12	0	0	CD
cord-259603-bh198xgl	125	13	-O	-O	:
cord-259603-bh198xgl	125	14	-	-	HYPH
cord-259603-bh198xgl	125	15	methyl	methyl	JJ
cord-259603-bh198xgl	125	16	transferase	transferase	NN
cord-259603-bh198xgl	125	17	,	,	,
cord-259603-bh198xgl	125	18	2	2	CD
cord-259603-bh198xgl	125	19	0	0	CD
cord-259603-bh198xgl	125	20	-O	-o	CD
cord-259603-bh198xgl	125	21	-	-	HYPH
cord-259603-bh198xgl	125	22	MTase	MTase	NNP
cord-259603-bh198xgl	125	23	)	)	-RRB-
cord-259603-bh198xgl	125	24	.	.	.
cord-259603-bh198xgl	126	1	Furthermore	furthermore	RB
cord-259603-bh198xgl	126	2	,	,	,
cord-259603-bh198xgl	126	3	several	several	JJ
cord-259603-bh198xgl	126	4	of	of	IN
cord-259603-bh198xgl	126	5	them	-PRON-	PRP
cord-259603-bh198xgl	126	6	have	have	VBP
cord-259603-bh198xgl	126	7	been	be	VBN
cord-259603-bh198xgl	126	8	predicted	predict	VBN
cord-259603-bh198xgl	126	9	or	or	CC
cord-259603-bh198xgl	126	10	shown	show	VBN
cord-259603-bh198xgl	126	11	to	to	TO
cord-259603-bh198xgl	126	12	interact	interact	VB
cord-259603-bh198xgl	126	13	with	with	IN
cord-259603-bh198xgl	126	14	RNA	RNA	NNP
cord-259603-bh198xgl	126	15	.	.	.
cord-259603-bh198xgl	127	1	Additionally	additionally	RB
cord-259603-bh198xgl	127	2	,	,	,
cord-259603-bh198xgl	127	3	a	a	DT
cord-259603-bh198xgl	127	4	fifth	fifth	JJ
cord-259603-bh198xgl	127	5	,	,	,
cord-259603-bh198xgl	127	6	very	very	RB
cord-259603-bh198xgl	127	7	small	small	JJ
cord-259603-bh198xgl	127	8	cleavage	cleavage	NN
cord-259603-bh198xgl	127	9	product	product	NN
cord-259603-bh198xgl	127	10	is	be	VBZ
cord-259603-bh198xgl	127	11	assumed	assume	VBN
cord-259603-bh198xgl	127	12	to	to	TO
cord-259603-bh198xgl	127	13	be	be	VB
cord-259603-bh198xgl	127	14	released	release	VBN
cord-259603-bh198xgl	127	15	from	from	IN
cord-259603-bh198xgl	127	16	this	this	DT
cord-259603-bh198xgl	127	17	region	region	NN
cord-259603-bh198xgl	127	18	of	of	IN
cord-259603-bh198xgl	127	19	pp1a	pp1a	NNP
cord-259603-bh198xgl	127	20	:	:	:
cord-259603-bh198xgl	127	21	the	the	DT
cord-259603-bh198xgl	127	22	nsp11	nsp11	NNP
cord-259603-bh198xgl	127	23	peptide	peptide	NN
cord-259603-bh198xgl	127	24	resulting	result	VBG
cord-259603-bh198xgl	127	25	from	from	IN
cord-259603-bh198xgl	127	26	cleavage	cleavage	NN
cord-259603-bh198xgl	127	27	of	of	IN
cord-259603-bh198xgl	127	28	pp1a	pp1a	NN
cord-259603-bh198xgl	127	29	at	at	IN
cord-259603-bh198xgl	127	30	the	the	DT
cord-259603-bh198xgl	127	31	nsp10/11	nsp10/11	NNPS
cord-259603-bh198xgl	127	32	junction	junction	NN
cord-259603-bh198xgl	127	33	(	(	-LRB-
cord-259603-bh198xgl	127	34	Fig	Fig	NNP
cord-259603-bh198xgl	127	35	.	.	.
cord-259603-bh198xgl	127	36	1	1	CD
cord-259603-bh198xgl	127	37	)	)	-RRB-
cord-259603-bh198xgl	127	38	.	.	.
cord-259603-bh198xgl	128	1	In	in	IN
cord-259603-bh198xgl	128	2	the	the	DT
cord-259603-bh198xgl	128	3	pp1ab	pp1ab	NNP
cord-259603-bh198xgl	128	4	frameshift	frameshift	NN
cord-259603-bh198xgl	128	5	product	product	NN
cord-259603-bh198xgl	128	6	,	,	,
cord-259603-bh198xgl	128	7	the	the	DT
cord-259603-bh198xgl	128	8	N	n	CD
cord-259603-bh198xgl	128	9	-	-	HYPH
cord-259603-bh198xgl	128	10	terminal	terminal	JJ
cord-259603-bh198xgl	128	11	sequence	sequence	NN
cord-259603-bh198xgl	128	12	of	of	IN
cord-259603-bh198xgl	128	13	nsp11	nsp11	ADD
cord-259603-bh198xgl	128	14	(	(	-LRB-
cord-259603-bh198xgl	128	15	encoded	encode	VBN
cord-259603-bh198xgl	128	16	between	between	IN
cord-259603-bh198xgl	128	17	the	the	DT
cord-259603-bh198xgl	128	18	nsp10/11	nsp10/11	NNPS
cord-259603-bh198xgl	128	19	junction	junction	NN
cord-259603-bh198xgl	128	20	and	and	CC
cord-259603-bh198xgl	128	21	ORF1a/1b	ORF1a/1b	NNP
cord-259603-bh198xgl	128	22	frameshift	frameshift	NN
cord-259603-bh198xgl	128	23	site	site	NN
cord-259603-bh198xgl	128	24	)	)	-RRB-
cord-259603-bh198xgl	128	25	equals	equal	VBZ
cord-259603-bh198xgl	128	26	the	the	DT
cord-259603-bh198xgl	128	27	N	n	CD
cord-259603-bh198xgl	128	28	-	-	HYPH
cord-259603-bh198xgl	128	29	terminal	terminal	JJ
cord-259603-bh198xgl	128	30	part	part	NN
cord-259603-bh198xgl	128	31	of	of	IN
cord-259603-bh198xgl	128	32	the	the	DT
cord-259603-bh198xgl	128	33	nsp12	nsp12	CD
cord-259603-bh198xgl	128	34	subunit	subunit	NN
cord-259603-bh198xgl	128	35	.	.	.
cord-259603-bh198xgl	129	1	Depending	depend	VBG
cord-259603-bh198xgl	129	2	on	on	IN
cord-259603-bh198xgl	129	3	the	the	DT
cord-259603-bh198xgl	129	4	CoV	cov	NN
cord-259603-bh198xgl	129	5	species	specie	NNS
cord-259603-bh198xgl	129	6	,	,	,
cord-259603-bh198xgl	129	7	nsp11	nsp11	ADD
cord-259603-bh198xgl	129	8	consists	consist	VBZ
cord-259603-bh198xgl	129	9	of	of	IN
cord-259603-bh198xgl	129	10	13	13	CD
cord-259603-bh198xgl	129	11	-	-	SYM
cord-259603-bh198xgl	129	12	23	23	CD
cord-259603-bh198xgl	129	13	residues	residue	NNS
cord-259603-bh198xgl	129	14	and	and	CC
cord-259603-bh198xgl	129	15	its	-PRON-	PRP$
cord-259603-bh198xgl	129	16	actual	actual	JJ
cord-259603-bh198xgl	129	17	release	release	NN
cord-259603-bh198xgl	129	18	,	,	,
cord-259603-bh198xgl	129	19	function	function	NN
cord-259603-bh198xgl	129	20	(	(	-LRB-
cord-259603-bh198xgl	129	21	if	if	IN
cord-259603-bh198xgl	129	22	any	any	DT
cord-259603-bh198xgl	129	23	)	)	-RRB-
cord-259603-bh198xgl	129	24	,	,	,
cord-259603-bh198xgl	129	25	or	or	CC
cord-259603-bh198xgl	129	26	fate	fate	NN
cord-259603-bh198xgl	129	27	in	in	IN
cord-259603-bh198xgl	129	28	CoV	cov	NN
cord-259603-bh198xgl	129	29	-	-	HYPH
cord-259603-bh198xgl	129	30	infected	infect	VBN
cord-259603-bh198xgl	129	31	cells	cell	NNS
cord-259603-bh198xgl	129	32	have	have	VBP
cord-259603-bh198xgl	129	33	not	not	RB
cord-259603-bh198xgl	129	34	been	be	VBN
cord-259603-bh198xgl	129	35	established	establish	VBN
cord-259603-bh198xgl	129	36	.	.	.
cord-259603-bh198xgl	130	1	In	in	IN
cord-259603-bh198xgl	130	2	cell	cell	NN
cord-259603-bh198xgl	130	3	culture	culture	NN
cord-259603-bh198xgl	130	4	models	model	NNS
cord-259603-bh198xgl	130	5	,	,	,
cord-259603-bh198xgl	130	6	for	for	IN
cord-259603-bh198xgl	130	7	some	some	DT
cord-259603-bh198xgl	130	8	(	(	-LRB-
cord-259603-bh198xgl	130	9	infectious	infectious	JJ
cord-259603-bh198xgl	130	10	bronchitis	bronchitis	NN
cord-259603-bh198xgl	130	11	virus	virus	NN
cord-259603-bh198xgl	130	12	(	(	-LRB-
cord-259603-bh198xgl	130	13	IBV	IBV	NNP
cord-259603-bh198xgl	130	14	)	)	-RRB-
cord-259603-bh198xgl	130	15	)	)	-RRB-
cord-259603-bh198xgl	130	16	but	but	CC
cord-259603-bh198xgl	130	17	not	not	RB
cord-259603-bh198xgl	130	18	other	other	JJ
cord-259603-bh198xgl	130	19	(	(	-LRB-
cord-259603-bh198xgl	130	20	MHV	MHV	NNP
cord-259603-bh198xgl	130	21	)	)	-RRB-
cord-259603-bh198xgl	130	22	CoVs	CoVs	NNP
cord-259603-bh198xgl	130	23	,	,	,
cord-259603-bh198xgl	130	24	the	the	DT
cord-259603-bh198xgl	130	25	nsp10/11	nsp10/11	NNS
cord-259603-bh198xgl	130	26	and	and	CC
cord-259603-bh198xgl	130	27	nsp10/12	nsp10/12	JJ
cord-259603-bh198xgl	130	28	cleavages	cleavage	NNS
cord-259603-bh198xgl	130	29	were	be	VBD
cord-259603-bh198xgl	130	30	found	find	VBN
cord-259603-bh198xgl	130	31	to	to	TO
cord-259603-bh198xgl	130	32	be	be	VB
cord-259603-bh198xgl	130	33	dispensable	dispensable	JJ
cord-259603-bh198xgl	130	34	for	for	IN
cord-259603-bh198xgl	130	35	virus	virus	NN
cord-259603-bh198xgl	130	36	replication	replication	NN
cord-259603-bh198xgl	130	37	(	(	-LRB-
cord-259603-bh198xgl	130	38	Deming	Deming	NNP
cord-259603-bh198xgl	130	39	et	et	NNP
cord-259603-bh198xgl	130	40	al	al	NNP
cord-259603-bh198xgl	130	41	.	.	NNP
cord-259603-bh198xgl	130	42	,	,	,
cord-259603-bh198xgl	130	43	2007	2007	CD
cord-259603-bh198xgl	130	44	;	;	.
cord-259603-bh198xgl	131	1	Fang	Fang	NNP
cord-259603-bh198xgl	131	2	et	et	FW
cord-259603-bh198xgl	131	3	al	al	NNP
cord-259603-bh198xgl	131	4	.	.	NNP
cord-259603-bh198xgl	131	5	,	,	,
cord-259603-bh198xgl	131	6	2008	2008	CD
cord-259603-bh198xgl	131	7	)	)	-RRB-
cord-259603-bh198xgl	131	8	,	,	,
cord-259603-bh198xgl	131	9	even	even	RB
cord-259603-bh198xgl	131	10	though	though	IN
cord-259603-bh198xgl	131	11	the	the	DT
cord-259603-bh198xgl	131	12	conservation	conservation	NN
cord-259603-bh198xgl	131	13	of	of	IN
cord-259603-bh198xgl	131	14	this	this	DT
cord-259603-bh198xgl	131	15	cleavage	cleavage	NN
cord-259603-bh198xgl	131	16	site	site	NN
cord-259603-bh198xgl	131	17	suggests	suggest	VBZ
cord-259603-bh198xgl	131	18	that	that	IN
cord-259603-bh198xgl	131	19	it	-PRON-	PRP
cord-259603-bh198xgl	131	20	is	be	VBZ
cord-259603-bh198xgl	131	21	generally	generally	RB
cord-259603-bh198xgl	131	22	required	require	VBN
cord-259603-bh198xgl	131	23	for	for	IN
cord-259603-bh198xgl	131	24	full	full	JJ
cord-259603-bh198xgl	131	25	replicase	replicase	NN
cord-259603-bh198xgl	131	26	functionality	functionality	NN
cord-259603-bh198xgl	131	27	.	.	.
cord-259603-bh198xgl	132	1	Processing	processing	NN
cord-259603-bh198xgl	132	2	of	of	IN
cord-259603-bh198xgl	132	3	the	the	DT
cord-259603-bh198xgl	132	4	nsp7-nsp10	nsp7-nsp10	JJ
cord-259603-bh198xgl	132	5	region	region	NN
cord-259603-bh198xgl	132	6	of	of	IN
cord-259603-bh198xgl	132	7	pp1a	pp1a	NNP
cord-259603-bh198xgl	132	8	/	/	SYM
cord-259603-bh198xgl	132	9	pp1ab	pp1ab	NNP
cord-259603-bh198xgl	132	10	has	have	VBZ
cord-259603-bh198xgl	132	11	been	be	VBN
cord-259603-bh198xgl	132	12	studied	study	VBN
cord-259603-bh198xgl	132	13	in	in	IN
cord-259603-bh198xgl	132	14	some	some	DT
cord-259603-bh198xgl	132	15	detail	detail	NN
cord-259603-bh198xgl	132	16	for	for	IN
cord-259603-bh198xgl	132	17	MHV	MHV	NNP
cord-259603-bh198xgl	132	18	(	(	-LRB-
cord-259603-bh198xgl	132	19	Bost	Bost	NNP
cord-259603-bh198xgl	132	20	et	et	NNP
cord-259603-bh198xgl	132	21	al	al	NNP
cord-259603-bh198xgl	132	22	.	.	NNP
cord-259603-bh198xgl	132	23	,	,	,
cord-259603-bh198xgl	132	24	2000	2000	CD
cord-259603-bh198xgl	132	25	;	;	:
cord-259603-bh198xgl	132	26	Deming	Deming	NNP
cord-259603-bh198xgl	132	27	et	et	NNP
cord-259603-bh198xgl	132	28	al	al	NNP
cord-259603-bh198xgl	132	29	.	.	NNP
cord-259603-bh198xgl	132	30	,	,	,
cord-259603-bh198xgl	132	31	2007	2007	CD
cord-259603-bh198xgl	132	32	)	)	-RRB-
cord-259603-bh198xgl	132	33	,	,	,
cord-259603-bh198xgl	132	34	human	human	JJ
cord-259603-bh198xgl	132	35	CoV	CoV	NNP
cord-259603-bh198xgl	132	36	229E	229E	NNP
cord-259603-bh198xgl	132	37	(	(	-LRB-
cord-259603-bh198xgl	132	38	HCoV-229E	HCoV-229E	NNP
cord-259603-bh198xgl	132	39	)	)	-RRB-
cord-259603-bh198xgl	133	1	(	(	-LRB-
cord-259603-bh198xgl	133	2	Ziebuhr	Ziebuhr	NNP
cord-259603-bh198xgl	133	3	and	and	CC
cord-259603-bh198xgl	133	4	Siddell	Siddell	NNP
cord-259603-bh198xgl	133	5	,	,	,
cord-259603-bh198xgl	133	6	1999	1999	CD
cord-259603-bh198xgl	133	7	)	)	-RRB-
cord-259603-bh198xgl	133	8	,	,	,
cord-259603-bh198xgl	133	9	and	and	CC
cord-259603-bh198xgl	133	10	IBV	IBV	NNP
cord-259603-bh198xgl	133	11	(	(	-LRB-
cord-259603-bh198xgl	133	12	Ng	Ng	NNP
cord-259603-bh198xgl	133	13	et	et	FW
cord-259603-bh198xgl	133	14	al	al	NNP
cord-259603-bh198xgl	133	15	.	.	NNP
cord-259603-bh198xgl	133	16	,	,	,
cord-259603-bh198xgl	133	17	2001	2001	CD
cord-259603-bh198xgl	133	18	)	)	-RRB-
cord-259603-bh198xgl	133	19	,	,	,
cord-259603-bh198xgl	133	20	confirming	confirm	VBG
cord-259603-bh198xgl	133	21	the	the	DT
cord-259603-bh198xgl	133	22	release	release	NN
cord-259603-bh198xgl	133	23	of	of	IN
cord-259603-bh198xgl	133	24	these	these	DT
cord-259603-bh198xgl	133	25	subunits	subunit	NNS
cord-259603-bh198xgl	133	26	in	in	IN
cord-259603-bh198xgl	133	27	infected	infected	JJ
cord-259603-bh198xgl	133	28	cells	cell	NNS
cord-259603-bh198xgl	133	29	and	and	CC
cord-259603-bh198xgl	133	30	the	the	DT
cord-259603-bh198xgl	133	31	use	use	NN
cord-259603-bh198xgl	133	32	of	of	IN
cord-259603-bh198xgl	133	33	the	the	DT
cord-259603-bh198xgl	133	34	predicted	predict	VBN
cord-259603-bh198xgl	133	35	3CL	3CL	NNP
cord-259603-bh198xgl	133	36	pro	pro	JJ
cord-259603-bh198xgl	133	37	cleavage	cleavage	NN
cord-259603-bh198xgl	133	38	sites	site	NNS
cord-259603-bh198xgl	133	39	.	.	.
cord-259603-bh198xgl	134	1	Processing	process	VBG
cord-259603-bh198xgl	134	2	at	at	IN
cord-259603-bh198xgl	134	3	these	these	DT
cord-259603-bh198xgl	134	4	sites	site	NNS
cord-259603-bh198xgl	134	5	was	be	VBD
cord-259603-bh198xgl	134	6	found	find	VBN
cord-259603-bh198xgl	134	7	to	to	TO
cord-259603-bh198xgl	134	8	be	be	VB
cord-259603-bh198xgl	134	9	critical	critical	JJ
cord-259603-bh198xgl	134	10	for	for	IN
cord-259603-bh198xgl	134	11	MHV	MHV	NNP
cord-259603-bh198xgl	134	12	replication	replication	NN
cord-259603-bh198xgl	134	13	,	,	,
cord-259603-bh198xgl	134	14	the	the	DT
cord-259603-bh198xgl	134	15	exception	exception	NN
cord-259603-bh198xgl	134	16	being	be	VBG
cord-259603-bh198xgl	134	17	inactivation	inactivation	NN
cord-259603-bh198xgl	134	18	of	of	IN
cord-259603-bh198xgl	134	19	the	the	DT
cord-259603-bh198xgl	134	20	nsp9/10	nsp9/10	NNP
cord-259603-bh198xgl	134	21	cleavage	cleavage	NN
cord-259603-bh198xgl	134	22	site	site	NN
cord-259603-bh198xgl	134	23	,	,	,
cord-259603-bh198xgl	134	24	which	which	WDT
cord-259603-bh198xgl	134	25	yielded	yield	VBD
cord-259603-bh198xgl	134	26	a	a	DT
cord-259603-bh198xgl	134	27	crippled	crippled	JJ
cord-259603-bh198xgl	134	28	mutant	mutant	JJ
cord-259603-bh198xgl	134	29	virus	virus	NN
cord-259603-bh198xgl	134	30	.	.	.
cord-259603-bh198xgl	135	1	Depending	depend	VBG
cord-259603-bh198xgl	135	2	on	on	IN
cord-259603-bh198xgl	135	3	antibody	antibody	NN
cord-259603-bh198xgl	135	4	availability	availability	NN
cord-259603-bh198xgl	135	5	,	,	,
cord-259603-bh198xgl	135	6	the	the	DT
cord-259603-bh198xgl	135	7	subcellular	subcellular	JJ
cord-259603-bh198xgl	135	8	localization	localization	NN
cord-259603-bh198xgl	135	9	of	of	IN
cord-259603-bh198xgl	135	10	nsp7	nsp7	NN
cord-259603-bh198xgl	135	11	to	to	IN
cord-259603-bh198xgl	135	12	nsp10	nsp10	NNP
cord-259603-bh198xgl	135	13	has	have	VBZ
cord-259603-bh198xgl	135	14	been	be	VBN
cord-259603-bh198xgl	135	15	studied	study	VBN
cord-259603-bh198xgl	135	16	for	for	IN
cord-259603-bh198xgl	135	17	several	several	JJ
cord-259603-bh198xgl	135	18	CoVs	covs	NN
cord-259603-bh198xgl	135	19	using	use	VBG
cord-259603-bh198xgl	135	20	immunofluorescence	immunofluorescence	NN
cord-259603-bh198xgl	135	21	microscopy	microscopy	NN
cord-259603-bh198xgl	135	22	.	.	.
cord-259603-bh198xgl	136	1	Without	without	IN
cord-259603-bh198xgl	136	2	exception	exception	NN
cord-259603-bh198xgl	136	3	,	,	,
cord-259603-bh198xgl	136	4	and	and	CC
cord-259603-bh198xgl	136	5	in	in	IN
cord-259603-bh198xgl	136	6	line	line	NN
cord-259603-bh198xgl	136	7	with	with	IN
cord-259603-bh198xgl	136	8	their	-PRON-	PRP$
cord-259603-bh198xgl	136	9	role	role	NN
cord-259603-bh198xgl	136	10	as	as	IN
cord-259603-bh198xgl	136	11	interaction	interaction	NN
cord-259603-bh198xgl	136	12	partner	partner	NN
cord-259603-bh198xgl	136	13	of	of	IN
cord-259603-bh198xgl	136	14	key	key	JJ
cord-259603-bh198xgl	136	15	replicative	replicative	JJ
cord-259603-bh198xgl	136	16	enzymes	enzyme	NNS
cord-259603-bh198xgl	136	17	,	,	,
cord-259603-bh198xgl	136	18	these	these	DT
cord-259603-bh198xgl	136	19	subunits	subunit	NNS
cord-259603-bh198xgl	136	20	localize	localize	VBP
cord-259603-bh198xgl	136	21	to	to	IN
cord-259603-bh198xgl	136	22	the	the	DT
cord-259603-bh198xgl	136	23	perinuclear	perinuclear	NNP
cord-259603-bh198xgl	136	24	region	region	NN
cord-259603-bh198xgl	136	25	of	of	IN
cord-259603-bh198xgl	136	26	infected	infected	JJ
cord-259603-bh198xgl	136	27	cells	cell	NNS
cord-259603-bh198xgl	137	1	(	(	-LRB-
cord-259603-bh198xgl	137	2	Bost	Bost	NNP
cord-259603-bh198xgl	137	3	et	et	NNP
cord-259603-bh198xgl	137	4	al	al	NNP
cord-259603-bh198xgl	137	5	.	.	NNP
cord-259603-bh198xgl	137	6	,	,	,
cord-259603-bh198xgl	137	7	2000	2000	CD
cord-259603-bh198xgl	137	8	)	)	-RRB-
cord-259603-bh198xgl	137	9	,	,	,
cord-259603-bh198xgl	137	10	where	where	WRB
cord-259603-bh198xgl	137	11	the	the	DT
cord-259603-bh198xgl	137	12	membranous	membranous	JJ
cord-259603-bh198xgl	137	13	replication	replication	NN
cord-259603-bh198xgl	137	14	organelles	organelle	NNS
cord-259603-bh198xgl	137	15	of	of	IN
cord-259603-bh198xgl	137	16	CoVs	CoVs	NNP
cord-259603-bh198xgl	137	17	accumulate	accumulate	VBP
cord-259603-bh198xgl	138	1	(	(	-LRB-
cord-259603-bh198xgl	138	2	Gosert	Gosert	NNP
cord-259603-bh198xgl	138	3	et	et	NNP
cord-259603-bh198xgl	138	4	al	al	NNP
cord-259603-bh198xgl	138	5	.	.	NNP
cord-259603-bh198xgl	138	6	,	,	,
cord-259603-bh198xgl	138	7	2002	2002	CD
cord-259603-bh198xgl	138	8	;	;	:
cord-259603-bh198xgl	139	1	Knoops	Knoops	NNP
cord-259603-bh198xgl	139	2	et	et	NNP
cord-259603-bh198xgl	139	3	al	al	NNP
cord-259603-bh198xgl	139	4	.	.	NNP
cord-259603-bh198xgl	139	5	,	,	,
cord-259603-bh198xgl	139	6	2008	2008	CD
cord-259603-bh198xgl	139	7	;	;	:
cord-259603-bh198xgl	139	8	Maier	Maier	NNP
cord-259603-bh198xgl	139	9	et	et	NNP
cord-259603-bh198xgl	139	10	al	al	NNP
cord-259603-bh198xgl	139	11	.	.	NNP
cord-259603-bh198xgl	139	12	,	,	,
cord-259603-bh198xgl	139	13	2013	2013	CD
cord-259603-bh198xgl	139	14	)	)	-RRB-
cord-259603-bh198xgl	139	15	.	.	.
cord-259603-bh198xgl	140	1	It	-PRON-	PRP
cord-259603-bh198xgl	140	2	should	should	MD
cord-259603-bh198xgl	140	3	be	be	VB
cord-259603-bh198xgl	140	4	noted	note	VBN
cord-259603-bh198xgl	140	5	,	,	,
cord-259603-bh198xgl	140	6	however	however	RB
cord-259603-bh198xgl	140	7	,	,	,
cord-259603-bh198xgl	140	8	that	that	IN
cord-259603-bh198xgl	140	9	these	these	DT
cord-259603-bh198xgl	140	10	labeling	labeling	NN
cord-259603-bh198xgl	140	11	techniques	technique	NNS
cord-259603-bh198xgl	140	12	can	can	MD
cord-259603-bh198xgl	140	13	not	not	RB
cord-259603-bh198xgl	140	14	distinguish	distinguish	VB
cord-259603-bh198xgl	140	15	between	between	IN
cord-259603-bh198xgl	140	16	fully	fully	RB
cord-259603-bh198xgl	140	17	processed	process	VBN
cord-259603-bh198xgl	140	18	nsps	nsp	NNS
cord-259603-bh198xgl	140	19	and	and	CC
cord-259603-bh198xgl	140	20	polyprotein	polyprotein	JJ
cord-259603-bh198xgl	140	21	precursors	precursor	NNS
cord-259603-bh198xgl	140	22	or	or	CC
cord-259603-bh198xgl	140	23	processing	processing	NN
cord-259603-bh198xgl	140	24	intermediates	intermediate	NNS
cord-259603-bh198xgl	140	25	.	.	.
cord-259603-bh198xgl	141	1	The	the	DT
cord-259603-bh198xgl	141	2	structure	structure	NN
cord-259603-bh198xgl	141	3	of	of	IN
cord-259603-bh198xgl	141	4	the	the	DT
cord-259603-bh198xgl	141	5	83-amino	83-amino	CD
cord-259603-bh198xgl	141	6	acid	acid	JJ
cord-259603-bh198xgl	141	7	SARS	SARS	NNP
cord-259603-bh198xgl	141	8	-	-	HYPH
cord-259603-bh198xgl	141	9	CoV	CoV	NNP
cord-259603-bh198xgl	141	10	nsp7	nsp7	NNP
cord-259603-bh198xgl	141	11	was	be	VBD
cord-259603-bh198xgl	141	12	determined	determine	VBN
cord-259603-bh198xgl	141	13	using	use	VBG
cord-259603-bh198xgl	141	14	both	both	CC
cord-259603-bh198xgl	141	15	NMR	NMR	NNP
cord-259603-bh198xgl	141	16	(	(	-LRB-
cord-259603-bh198xgl	141	17	Peti	Peti	NNP
cord-259603-bh198xgl	141	18	et	et	NNP
cord-259603-bh198xgl	141	19	al	al	NNP
cord-259603-bh198xgl	141	20	.	.	NNP
cord-259603-bh198xgl	141	21	,	,	,
cord-259603-bh198xgl	141	22	2005	2005	CD
cord-259603-bh198xgl	141	23	)	)	-RRB-
cord-259603-bh198xgl	141	24	and	and	CC
cord-259603-bh198xgl	141	25	X	x	NN
cord-259603-bh198xgl	141	26	-	-	NN
cord-259603-bh198xgl	141	27	ray	ray	NN
cord-259603-bh198xgl	141	28	crystallography	crystallography	NN
cord-259603-bh198xgl	142	1	(	(	-LRB-
cord-259603-bh198xgl	142	2	Zhai	Zhai	NNP
cord-259603-bh198xgl	142	3	et	et	NNP
cord-259603-bh198xgl	142	4	al	al	NNP
cord-259603-bh198xgl	142	5	.	.	NNP
cord-259603-bh198xgl	142	6	,	,	,
cord-259603-bh198xgl	142	7	2005	2005	CD
cord-259603-bh198xgl	142	8	)	)	-RRB-
cord-259603-bh198xgl	142	9	,	,	,
cord-259603-bh198xgl	142	10	with	with	IN
cord-259603-bh198xgl	142	11	the	the	DT
cord-259603-bh198xgl	142	12	latter	latter	JJ
cord-259603-bh198xgl	142	13	study	study	NN
cord-259603-bh198xgl	142	14	resolving	resolve	VBG
cord-259603-bh198xgl	142	15	the	the	DT
cord-259603-bh198xgl	142	16	structure	structure	NN
cord-259603-bh198xgl	142	17	of	of	IN
cord-259603-bh198xgl	142	18	a	a	DT
cord-259603-bh198xgl	142	19	hexadecameric	hexadecameric	JJ
cord-259603-bh198xgl	142	20	supercomplex	supercomplex	NN
cord-259603-bh198xgl	142	21	consisting	consist	VBG
cord-259603-bh198xgl	142	22	of	of	IN
cord-259603-bh198xgl	142	23	recombinant	recombinant	JJ
cord-259603-bh198xgl	142	24	nsp7	nsp7	NN
cord-259603-bh198xgl	142	25	and	and	CC
cord-259603-bh198xgl	142	26	nsp8	nsp8	NN
cord-259603-bh198xgl	143	1	(	(	-LRB-
cord-259603-bh198xgl	143	2	see	see	VB
cord-259603-bh198xgl	143	3	later	later	RBR
cord-259603-bh198xgl	143	4	;	;	:
cord-259603-bh198xgl	143	5	Fig	Fig	NNP
cord-259603-bh198xgl	143	6	.	.	NNP
cord-259603-bh198xgl	143	7	2	2	CD
cord-259603-bh198xgl	143	8	)	)	-RRB-
cord-259603-bh198xgl	143	9	.	.	.
cord-259603-bh198xgl	144	1	In	in	IN
cord-259603-bh198xgl	144	2	both	both	DT
cord-259603-bh198xgl	144	3	structures	structure	NNS
cord-259603-bh198xgl	144	4	,	,	,
cord-259603-bh198xgl	144	5	the	the	DT
cord-259603-bh198xgl	144	6	nsp7-fold	nsp7-fold	NNP
cord-259603-bh198xgl	144	7	includes	include	VBZ
cord-259603-bh198xgl	144	8	four	four	CD
cord-259603-bh198xgl	144	9	helices	helix	NNS
cord-259603-bh198xgl	144	10	,	,	,
cord-259603-bh198xgl	144	11	but	but	CC
cord-259603-bh198xgl	144	12	their	-PRON-	PRP$
cord-259603-bh198xgl	144	13	position	position	NN
cord-259603-bh198xgl	144	14	and	and	CC
cord-259603-bh198xgl	144	15	spatial	spatial	JJ
cord-259603-bh198xgl	144	16	orientation	orientation	NN
cord-259603-bh198xgl	144	17	is	be	VBZ
cord-259603-bh198xgl	144	18	quite	quite	RB
cord-259603-bh198xgl	144	19	different	different	JJ
cord-259603-bh198xgl	144	20	,	,	,
cord-259603-bh198xgl	144	21	suggesting	suggest	VBG
cord-259603-bh198xgl	144	22	that	that	IN
cord-259603-bh198xgl	144	23	the	the	DT
cord-259603-bh198xgl	144	24	protein	protein	NN
cord-259603-bh198xgl	144	25	's	's	POS
cord-259603-bh198xgl	144	26	conformation	conformation	NN
cord-259603-bh198xgl	144	27	is	be	VBZ
cord-259603-bh198xgl	144	28	strongly	strongly	RB
cord-259603-bh198xgl	144	29	affected	affect	VBN
cord-259603-bh198xgl	144	30	by	by	IN
cord-259603-bh198xgl	144	31	the	the	DT
cord-259603-bh198xgl	144	32	interaction	interaction	NN
cord-259603-bh198xgl	144	33	with	with	IN
cord-259603-bh198xgl	144	34	nsp8	nsp8	NN
cord-259603-bh198xgl	144	35	,	,	,
cord-259603-bh198xgl	144	36	in	in	IN
cord-259603-bh198xgl	144	37	particular	particular	JJ
cord-259603-bh198xgl	144	38	,	,	,
cord-259603-bh198xgl	144	39	where	where	WRB
cord-259603-bh198xgl	144	40	it	-PRON-	PRP
cord-259603-bh198xgl	144	41	concerns	concern	VBZ
cord-259603-bh198xgl	144	42	helix	helix	NN
cord-259603-bh198xgl	144	43	α4	α4	NN
cord-259603-bh198xgl	145	1	(	(	-LRB-
cord-259603-bh198xgl	145	2	Johnson	Johnson	NNP
cord-259603-bh198xgl	145	3	et	et	NNP
cord-259603-bh198xgl	145	4	al	al	NNP
cord-259603-bh198xgl	145	5	.	.	NNP
cord-259603-bh198xgl	145	6	,	,	,
cord-259603-bh198xgl	145	7	2010	2010	CD
cord-259603-bh198xgl	145	8	)	)	-RRB-
cord-259603-bh198xgl	145	9	.	.	.
cord-259603-bh198xgl	146	1	Reverse	reverse	NN
cord-259603-bh198xgl	146	2	-	-	HYPH
cord-259603-bh198xgl	146	3	genetics	genetics	NN
cord-259603-bh198xgl	146	4	studies	study	NNS
cord-259603-bh198xgl	146	5	targeting	target	VBG
cord-259603-bh198xgl	146	6	specific	specific	JJ
cord-259603-bh198xgl	146	7	residues	residue	NNS
cord-259603-bh198xgl	146	8	in	in	IN
cord-259603-bh198xgl	146	9	SARS	SARS	NNP
cord-259603-bh198xgl	146	10	-	-	HYPH
cord-259603-bh198xgl	146	11	CoV	CoV	NNP
cord-259603-bh198xgl	146	12	nsp7	nsp7	NNP
cord-259603-bh198xgl	146	13	confirmed	confirm	VBD
cord-259603-bh198xgl	146	14	the	the	DT
cord-259603-bh198xgl	146	15	protein	protein	NN
cord-259603-bh198xgl	146	16	's	's	POS
cord-259603-bh198xgl	146	17	importance	importance	NN
cord-259603-bh198xgl	146	18	for	for	IN
cord-259603-bh198xgl	146	19	virus	virus	NN
cord-259603-bh198xgl	146	20	replication	replication	NN
cord-259603-bh198xgl	146	21	(	(	-LRB-
cord-259603-bh198xgl	146	22	Subissi	Subissi	NNP
cord-259603-bh198xgl	146	23	et	et	NNP
cord-259603-bh198xgl	146	24	al	al	NNP
cord-259603-bh198xgl	146	25	.	.	NNP
cord-259603-bh198xgl	146	26	,	,	,
cord-259603-bh198xgl	146	27	2014b	2014b	CD
cord-259603-bh198xgl	146	28	)	)	-RRB-
cord-259603-bh198xgl	146	29	,	,	,
cord-259603-bh198xgl	146	30	although	although	IN
cord-259603-bh198xgl	146	31	the	the	DT
cord-259603-bh198xgl	146	32	impact	impact	NN
cord-259603-bh198xgl	146	33	of	of	IN
cord-259603-bh198xgl	146	34	single	single	JJ
cord-259603-bh198xgl	146	35	point	point	NN
cord-259603-bh198xgl	146	36	mutations	mutation	NNS
cord-259603-bh198xgl	146	37	was	be	VBD
cord-259603-bh198xgl	146	38	smaller	small	JJR
cord-259603-bh198xgl	146	39	than	than	IN
cord-259603-bh198xgl	146	40	anticipated	anticipate	VBN
cord-259603-bh198xgl	146	41	on	on	IN
cord-259603-bh198xgl	146	42	the	the	DT
cord-259603-bh198xgl	146	43	basis	basis	NN
cord-259603-bh198xgl	146	44	of	of	IN
cord-259603-bh198xgl	146	45	the	the	DT
cord-259603-bh198xgl	146	46	biochemical	biochemical	JJ
cord-259603-bh198xgl	146	47	characterization	characterization	NN
cord-259603-bh198xgl	146	48	of	of	IN
cord-259603-bh198xgl	146	49	the	the	DT
cord-259603-bh198xgl	146	50	RNA	RNA	NNP
cord-259603-bh198xgl	146	51	-	-	HYPH
cord-259603-bh198xgl	146	52	binding	bind	VBG
cord-259603-bh198xgl	146	53	properties	property	NNS
cord-259603-bh198xgl	146	54	of	of	IN
cord-259603-bh198xgl	146	55	nsp7-containing	nsp7-containing	NNP
cord-259603-bh198xgl	146	56	protein	protein	NN
cord-259603-bh198xgl	146	57	complexes	complex	NNS
cord-259603-bh198xgl	146	58	in	in	IN
cord-259603-bh198xgl	146	59	vitro	vitro	FW
cord-259603-bh198xgl	146	60	(	(	-LRB-
cord-259603-bh198xgl	146	61	see	see	VB
cord-259603-bh198xgl	146	62	later	later	RB
cord-259603-bh198xgl	146	63	)	)	-RRB-
cord-259603-bh198xgl	146	64	.	.	.
cord-259603-bh198xgl	147	1	The	the	DT
cord-259603-bh198xgl	147	2	$	$	$
cord-259603-bh198xgl	147	3	200-amino	200-amino	CD
cord-259603-bh198xgl	147	4	-	-	HYPH
cord-259603-bh198xgl	147	5	acid	acid	NN
cord-259603-bh198xgl	147	6	-	-	HYPH
cord-259603-bh198xgl	147	7	long	long	JJ
cord-259603-bh198xgl	147	8	nsp8	nsp8	JJ
cord-259603-bh198xgl	147	9	subunit	subunit	NN
cord-259603-bh198xgl	147	10	initially	initially	RB
cord-259603-bh198xgl	147	11	took	take	VBD
cord-259603-bh198xgl	147	12	center	center	JJ
cord-259603-bh198xgl	147	13	stage	stage	NN
cord-259603-bh198xgl	147	14	due	due	IN
cord-259603-bh198xgl	147	15	to	to	IN
cord-259603-bh198xgl	147	16	two	two	CD
cord-259603-bh198xgl	147	17	studies	study	NNS
cord-259603-bh198xgl	147	18	,	,	,
cord-259603-bh198xgl	147	19	the	the	DT
cord-259603-bh198xgl	147	20	first	first	JJ
cord-259603-bh198xgl	147	21	describing	describe	VBG
cord-259603-bh198xgl	147	22	a	a	DT
cord-259603-bh198xgl	147	23	fascinating	fascinating	JJ
cord-259603-bh198xgl	147	24	hexadecameric	hexadecameric	JJ
cord-259603-bh198xgl	147	25	structure	structure	NN
cord-259603-bh198xgl	147	26	consisting	consist	VBG
cord-259603-bh198xgl	147	27	of	of	IN
cord-259603-bh198xgl	147	28	eight	eight	CD
cord-259603-bh198xgl	147	29	copies	copy	NNS
cord-259603-bh198xgl	147	30	each	each	DT
cord-259603-bh198xgl	147	31	of	of	IN
cord-259603-bh198xgl	147	32	nsp7	nsp7	NN
cord-259603-bh198xgl	147	33	and	and	CC
cord-259603-bh198xgl	147	34	nsp8	nsp8	NN
cord-259603-bh198xgl	147	35	(	(	-LRB-
cord-259603-bh198xgl	147	36	Fig	fig	NN
cord-259603-bh198xgl	147	37	.	.	NNP
cord-259603-bh198xgl	147	38	2	2	LS
cord-259603-bh198xgl	147	39	)	)	-RRB-
cord-259603-bh198xgl	147	40	(	(	-LRB-
cord-259603-bh198xgl	147	41	Zhai	Zhai	NNP
cord-259603-bh198xgl	147	42	et	et	NNP
cord-259603-bh198xgl	147	43	al	al	NNP
cord-259603-bh198xgl	147	44	.	.	NNP
cord-259603-bh198xgl	147	45	,	,	,
cord-259603-bh198xgl	147	46	2005	2005	CD
cord-259603-bh198xgl	147	47	)	)	-RRB-
cord-259603-bh198xgl	147	48	,	,	,
cord-259603-bh198xgl	147	49	and	and	CC
cord-259603-bh198xgl	147	50	the	the	DT
cord-259603-bh198xgl	147	51	second	second	JJ
cord-259603-bh198xgl	147	52	reporting	report	VBG
cord-259603-bh198xgl	147	53	an	an	DT
cord-259603-bh198xgl	147	54	nsp8-specific	nsp8-specific	NNP
cord-259603-bh198xgl	147	55	"	"	``
cord-259603-bh198xgl	147	56	secondary	secondary	JJ
cord-259603-bh198xgl	147	57	"	"	''
cord-259603-bh198xgl	147	58	RNA	rna	NN
cord-259603-bh198xgl	147	59	polymerase	polymerase	NN
cord-259603-bh198xgl	147	60	Fig	Fig	NNP
cord-259603-bh198xgl	147	61	.	.	NNP
cord-259603-bh198xgl	147	62	2	2	CD
cord-259603-bh198xgl	147	63	Crystal	Crystal	NNP
cord-259603-bh198xgl	147	64	structure	structure	NN
cord-259603-bh198xgl	147	65	of	of	IN
cord-259603-bh198xgl	147	66	the	the	DT
cord-259603-bh198xgl	147	67	SARS	SARS	NNP
cord-259603-bh198xgl	147	68	-	-	HYPH
cord-259603-bh198xgl	147	69	CoV	CoV	NNP
cord-259603-bh198xgl	147	70	nsp7-nsp8	nsp7-nsp8	CD
cord-259603-bh198xgl	148	1	hexadecamer	hexadecamer	NNP
cord-259603-bh198xgl	148	2	(	(	-LRB-
cord-259603-bh198xgl	148	3	pdb	pdb	NNP
cord-259603-bh198xgl	148	4	2AHM	2ahm	CD
cord-259603-bh198xgl	148	5	)	)	-RRB-
cord-259603-bh198xgl	149	1	(	(	-LRB-
cord-259603-bh198xgl	149	2	Zhai	Zhai	NNP
cord-259603-bh198xgl	149	3	et	et	NNP
cord-259603-bh198xgl	149	4	al	al	NNP
cord-259603-bh198xgl	149	5	.	.	NNP
cord-259603-bh198xgl	149	6	,	,	,
cord-259603-bh198xgl	149	7	2005	2005	CD
cord-259603-bh198xgl	149	8	)	)	-RRB-
cord-259603-bh198xgl	149	9	.	.	.
cord-259603-bh198xgl	150	1	Purified	purify	VBN
cord-259603-bh198xgl	150	2	recombinant	recombinant	JJ
cord-259603-bh198xgl	150	3	SARS	SARS	NNP
cord-259603-bh198xgl	150	4	-	-	HYPH
cord-259603-bh198xgl	150	5	CoV	CoV	NNP
cord-259603-bh198xgl	150	6	nsp7	nsp7	NN
cord-259603-bh198xgl	150	7	and	and	CC
cord-259603-bh198xgl	150	8	nsp8	nsp8	NN
cord-259603-bh198xgl	150	9	were	be	VBD
cord-259603-bh198xgl	150	10	found	find	VBN
cord-259603-bh198xgl	150	11	to	to	IN
cord-259603-bh198xgl	150	12	self	self	NN
cord-259603-bh198xgl	150	13	-	-	HYPH
cord-259603-bh198xgl	150	14	assemble	assemble	VB
cord-259603-bh198xgl	150	15	into	into	IN
cord-259603-bh198xgl	150	16	a	a	DT
cord-259603-bh198xgl	150	17	supercomplex	supercomplex	NN
cord-259603-bh198xgl	150	18	of	of	IN
cord-259603-bh198xgl	150	19	which	which	WDT
cord-259603-bh198xgl	150	20	the	the	DT
cord-259603-bh198xgl	150	21	structure	structure	NN
cord-259603-bh198xgl	150	22	was	be	VBD
cord-259603-bh198xgl	150	23	determined	determine	VBN
cord-259603-bh198xgl	150	24	at	at	IN
cord-259603-bh198xgl	150	25	2.4	2.4	CD
cord-259603-bh198xgl	150	26	Å	å	NN
cord-259603-bh198xgl	150	27	resolution	resolution	NN
cord-259603-bh198xgl	150	28	.	.	.
cord-259603-bh198xgl	151	1	(	(	-LRB-
cord-259603-bh198xgl	151	2	A	a	NN
cord-259603-bh198xgl	151	3	)	)	-RRB-
cord-259603-bh198xgl	152	1	The	the	DT
cord-259603-bh198xgl	152	2	complex	complex	JJ
cord-259603-bh198xgl	152	3	forms	form	VBZ
cord-259603-bh198xgl	152	4	a	a	DT
cord-259603-bh198xgl	152	5	doughnut	doughnut	NN
cord-259603-bh198xgl	152	6	-	-	HYPH
cord-259603-bh198xgl	152	7	shaped	shape	VBN
cord-259603-bh198xgl	152	8	hollow	hollow	JJ
cord-259603-bh198xgl	152	9	structure	structure	NN
cord-259603-bh198xgl	152	10	of	of	IN
cord-259603-bh198xgl	152	11	which	which	WDT
cord-259603-bh198xgl	152	12	the	the	DT
cord-259603-bh198xgl	152	13	central	central	JJ
cord-259603-bh198xgl	152	14	channel	channel	NN
cord-259603-bh198xgl	152	15	is	be	VBZ
cord-259603-bh198xgl	152	16	lined	line	VBN
cord-259603-bh198xgl	152	17	with	with	IN
cord-259603-bh198xgl	152	18	positively	positively	RB
cord-259603-bh198xgl	152	19	charged	charge	VBN
cord-259603-bh198xgl	152	20	side	side	NN
cord-259603-bh198xgl	152	21	chains	chain	NNS
cord-259603-bh198xgl	152	22	(	(	-LRB-
cord-259603-bh198xgl	152	23	in	in	IN
cord-259603-bh198xgl	152	24	blue	blue	JJ
cord-259603-bh198xgl	152	25	)	)	-RRB-
cord-259603-bh198xgl	152	26	and	and	CC
cord-259603-bh198xgl	152	27	was	be	VBD
cord-259603-bh198xgl	152	28	postulated	postulate	VBN
cord-259603-bh198xgl	152	29	to	to	TO
cord-259603-bh198xgl	152	30	mediate	mediate	VB
cord-259603-bh198xgl	152	31	doublestranded	doublestranded	JJ
cord-259603-bh198xgl	152	32	RNA	RNA	NNP
cord-259603-bh198xgl	152	33	binding	binding	NN
cord-259603-bh198xgl	152	34	.	.	.
cord-259603-bh198xgl	153	1	The	the	DT
cord-259603-bh198xgl	153	2	outside	outside	NN
cord-259603-bh198xgl	153	3	of	of	IN
cord-259603-bh198xgl	153	4	the	the	DT
cord-259603-bh198xgl	153	5	structure	structure	NN
cord-259603-bh198xgl	153	6	is	be	VBZ
cord-259603-bh198xgl	153	7	predominantly	predominantly	RB
cord-259603-bh198xgl	153	8	negatively	negatively	RB
cord-259603-bh198xgl	153	9	charged	charge	VBN
cord-259603-bh198xgl	153	10	(	(	-LRB-
cord-259603-bh198xgl	153	11	red	red	JJ
cord-259603-bh198xgl	153	12	)	)	-RRB-
cord-259603-bh198xgl	153	13	surface	surface	NN
cord-259603-bh198xgl	153	14	shading	shading	NN
cord-259603-bh198xgl	153	15	)	)	-RRB-
cord-259603-bh198xgl	153	16	.	.	.
cord-259603-bh198xgl	154	1	(	(	-LRB-
cord-259603-bh198xgl	154	2	B	b	NN
cord-259603-bh198xgl	154	3	and	and	CC
cord-259603-bh198xgl	154	4	C	C	NNP
cord-259603-bh198xgl	154	5	)	)	-RRB-
cord-259603-bh198xgl	155	1	SARS	SARS	NNP
cord-259603-bh198xgl	155	2	-	-	HYPH
cord-259603-bh198xgl	155	3	CoV	CoV	NNP
cord-259603-bh198xgl	155	4	nsp8	nsp8	NN
cord-259603-bh198xgl	155	5	resembles	resemble	VBZ
cord-259603-bh198xgl	155	6	a	a	DT
cord-259603-bh198xgl	155	7	"	"	``
cord-259603-bh198xgl	155	8	golf	golf	NN
cord-259603-bh198xgl	155	9	club"-like	club"-like	IN
cord-259603-bh198xgl	155	10	shape	shape	NN
cord-259603-bh198xgl	155	11	that	that	WDT
cord-259603-bh198xgl	155	12	can	can	MD
cord-259603-bh198xgl	155	13	adopt	adopt	VB
cord-259603-bh198xgl	155	14	two	two	CD
cord-259603-bh198xgl	155	15	conformations	conformation	NNS
cord-259603-bh198xgl	155	16	,	,	,
cord-259603-bh198xgl	155	17	as	as	IN
cord-259603-bh198xgl	155	18	presented	present	VBN
cord-259603-bh198xgl	155	19	here	here	RB
cord-259603-bh198xgl	155	20	in	in	IN
cord-259603-bh198xgl	155	21	orange	orange	JJ
cord-259603-bh198xgl	155	22	and	and	CC
cord-259603-bh198xgl	155	23	green	green	JJ
cord-259603-bh198xgl	155	24	.	.	.
cord-259603-bh198xgl	156	1	These	these	DT
cord-259603-bh198xgl	156	2	nsp8	nsp8	JJ
cord-259603-bh198xgl	156	3	conformations	conformation	NNS
cord-259603-bh198xgl	156	4	are	be	VBP
cord-259603-bh198xgl	156	5	integrated	integrate	VBN
cord-259603-bh198xgl	156	6	into	into	IN
cord-259603-bh198xgl	156	7	a	a	DT
cord-259603-bh198xgl	156	8	much	much	RB
cord-259603-bh198xgl	156	9	larger	large	JJR
cord-259603-bh198xgl	156	10	,	,	,
cord-259603-bh198xgl	156	11	hexadecameric	hexadecameric	NNP
cord-259603-bh198xgl	156	12	structure	structure	NN
cord-259603-bh198xgl	156	13	that	that	WDT
cord-259603-bh198xgl	156	14	is	be	VBZ
cord-259603-bh198xgl	156	15	composed	compose	VBN
cord-259603-bh198xgl	156	16	of	of	IN
cord-259603-bh198xgl	156	17	eight	eight	CD
cord-259603-bh198xgl	156	18	nsp8	nsp8	JJ
cord-259603-bh198xgl	156	19	subunits	subunit	NNS
cord-259603-bh198xgl	156	20	and	and	CC
cord-259603-bh198xgl	156	21	eight	eight	CD
cord-259603-bh198xgl	156	22	nsp7	nsp7	JJ
cord-259603-bh198xgl	156	23	subunits	subunit	NNS
cord-259603-bh198xgl	156	24	,	,	,
cord-259603-bh198xgl	156	25	of	of	IN
cord-259603-bh198xgl	156	26	which	which	WDT
cord-259603-bh198xgl	156	27	one	one	NN
cord-259603-bh198xgl	156	28	is	be	VBZ
cord-259603-bh198xgl	156	29	shaded	shade	VBN
cord-259603-bh198xgl	156	30	pink	pink	NN
cord-259603-bh198xgl	156	31	.	.	.
cord-259603-bh198xgl	157	1	In	in	IN
cord-259603-bh198xgl	157	2	(	(	-LRB-
cord-259603-bh198xgl	157	3	B	b	NN
cord-259603-bh198xgl	157	4	)	)	-RRB-
cord-259603-bh198xgl	157	5	,	,	,
cord-259603-bh198xgl	157	6	the	the	DT
cord-259603-bh198xgl	157	7	hexadecamer	hexadecamer	NN
cord-259603-bh198xgl	157	8	is	be	VBZ
cord-259603-bh198xgl	157	9	depicted	depict	VBN
cord-259603-bh198xgl	157	10	against	against	IN
cord-259603-bh198xgl	157	11	the	the	DT
cord-259603-bh198xgl	157	12	background	background	NN
cord-259603-bh198xgl	157	13	of	of	IN
cord-259603-bh198xgl	157	14	the	the	DT
cord-259603-bh198xgl	157	15	surface	surface	NN
cord-259603-bh198xgl	157	16	plot	plot	NN
cord-259603-bh198xgl	157	17	presented	present	VBN
cord-259603-bh198xgl	157	18	in	in	IN
cord-259603-bh198xgl	157	19	(	(	-LRB-
cord-259603-bh198xgl	157	20	A	a	NN
cord-259603-bh198xgl	157	21	)	)	-RRB-
cord-259603-bh198xgl	157	22	.	.	.
cord-259603-bh198xgl	158	1	activity	activity	NN
cord-259603-bh198xgl	158	2	(	(	-LRB-
cord-259603-bh198xgl	158	3	Imbert	Imbert	NNP
cord-259603-bh198xgl	158	4	et	et	FW
cord-259603-bh198xgl	158	5	al	al	NNP
cord-259603-bh198xgl	158	6	.	.	NNP
cord-259603-bh198xgl	158	7	,	,	,
cord-259603-bh198xgl	158	8	2006	2006	CD
cord-259603-bh198xgl	158	9	)	)	-RRB-
cord-259603-bh198xgl	158	10	that	that	WDT
cord-259603-bh198xgl	158	11	was	be	VBD
cord-259603-bh198xgl	158	12	implicated	implicate	VBN
cord-259603-bh198xgl	158	13	in	in	IN
cord-259603-bh198xgl	158	14	the	the	DT
cord-259603-bh198xgl	158	15	mechanism	mechanism	NN
cord-259603-bh198xgl	158	16	of	of	IN
cord-259603-bh198xgl	158	17	initiation	initiation	NN
cord-259603-bh198xgl	158	18	of	of	IN
cord-259603-bh198xgl	158	19	CoV	CoV	NNP
cord-259603-bh198xgl	158	20	RNA	RNA	NNP
cord-259603-bh198xgl	158	21	synthesis	synthesis	NN
cord-259603-bh198xgl	158	22	.	.	.
cord-259603-bh198xgl	159	1	This	this	DT
cord-259603-bh198xgl	159	2	template	template	NN
cord-259603-bh198xgl	159	3	-	-	HYPH
cord-259603-bh198xgl	159	4	dependent	dependent	JJ
cord-259603-bh198xgl	159	5	activity	activity	NN
cord-259603-bh198xgl	159	6	was	be	VBD
cord-259603-bh198xgl	159	7	reported	report	VBN
cord-259603-bh198xgl	159	8	to	to	TO
cord-259603-bh198xgl	159	9	depend	depend	VB
cord-259603-bh198xgl	159	10	on	on	IN
cord-259603-bh198xgl	159	11	the	the	DT
cord-259603-bh198xgl	159	12	presence	presence	NN
cord-259603-bh198xgl	159	13	of	of	IN
cord-259603-bh198xgl	159	14	Mn	Mn	NNP
cord-259603-bh198xgl	159	15	2	2	CD
cord-259603-bh198xgl	159	16	+	+	SYM
cord-259603-bh198xgl	159	17	or	or	CC
cord-259603-bh198xgl	159	18	Mg	Mg	NNP
cord-259603-bh198xgl	159	19	2	2	CD
cord-259603-bh198xgl	159	20	+	+	SYM
cord-259603-bh198xgl	159	21	and	and	CC
cord-259603-bh198xgl	159	22	to	to	TO
cord-259603-bh198xgl	159	23	typically	typically	RB
cord-259603-bh198xgl	159	24	generate	generate	VB
cord-259603-bh198xgl	159	25	products	product	NNS
cord-259603-bh198xgl	159	26	of	of	IN
cord-259603-bh198xgl	159	27	up	up	IN
cord-259603-bh198xgl	159	28	to	to	TO
cord-259603-bh198xgl	159	29	six	six	CD
cord-259603-bh198xgl	159	30	nucleotides	nucleotide	NNS
cord-259603-bh198xgl	159	31	(	(	-LRB-
cord-259603-bh198xgl	159	32	for	for	IN
cord-259603-bh198xgl	159	33	more	more	JJR
cord-259603-bh198xgl	159	34	details	detail	NNS
cord-259603-bh198xgl	159	35	,	,	,
cord-259603-bh198xgl	159	36	see	see	VB
cord-259603-bh198xgl	159	37	Section	section	NN
cord-259603-bh198xgl	159	38	3.2	3.2	CD
cord-259603-bh198xgl	159	39	)	)	-RRB-
cord-259603-bh198xgl	159	40	.	.	.
cord-259603-bh198xgl	160	1	Around	around	IN
cord-259603-bh198xgl	160	2	the	the	DT
cord-259603-bh198xgl	160	3	same	same	JJ
cord-259603-bh198xgl	160	4	time	time	NN
cord-259603-bh198xgl	160	5	,	,	,
cord-259603-bh198xgl	160	6	purified	purify	VBN
cord-259603-bh198xgl	160	7	recombinant	recombinant	JJ
cord-259603-bh198xgl	160	8	SARS	SARS	NNP
cord-259603-bh198xgl	160	9	-	-	HYPH
cord-259603-bh198xgl	160	10	CoV	CoV	NNP
cord-259603-bh198xgl	160	11	nsp7	nsp7	NN
cord-259603-bh198xgl	160	12	and	and	CC
cord-259603-bh198xgl	160	13	nsp8	nsp8	NN
cord-259603-bh198xgl	160	14	were	be	VBD
cord-259603-bh198xgl	160	15	found	find	VBN
cord-259603-bh198xgl	160	16	to	to	IN
cord-259603-bh198xgl	160	17	self	self	NN
cord-259603-bh198xgl	160	18	-	-	HYPH
cord-259603-bh198xgl	160	19	assemble	assemble	VB
cord-259603-bh198xgl	160	20	into	into	IN
cord-259603-bh198xgl	160	21	the	the	DT
cord-259603-bh198xgl	160	22	hexadecameric	hexadecameric	NNP
cord-259603-bh198xgl	160	23	supercomplex	supercomplex	NN
cord-259603-bh198xgl	160	24	of	of	IN
cord-259603-bh198xgl	160	25	which	which	WDT
cord-259603-bh198xgl	160	26	the	the	DT
cord-259603-bh198xgl	160	27	structure	structure	NN
cord-259603-bh198xgl	160	28	was	be	VBD
cord-259603-bh198xgl	160	29	determined	determine	VBN
cord-259603-bh198xgl	160	30	at	at	IN
cord-259603-bh198xgl	160	31	2.4	2.4	CD
cord-259603-bh198xgl	160	32	Å	å	NN
cord-259603-bh198xgl	160	33	resolution	resolution	NN
cord-259603-bh198xgl	160	34	(	(	-LRB-
cord-259603-bh198xgl	160	35	Zhai	Zhai	NNP
cord-259603-bh198xgl	160	36	et	et	NNP
cord-259603-bh198xgl	160	37	al	al	NNP
cord-259603-bh198xgl	160	38	.	.	NNP
cord-259603-bh198xgl	160	39	,	,	,
cord-259603-bh198xgl	160	40	2005	2005	CD
cord-259603-bh198xgl	160	41	)	)	-RRB-
cord-259603-bh198xgl	160	42	.	.	.
cord-259603-bh198xgl	161	1	The	the	DT
cord-259603-bh198xgl	161	2	complex	complex	NN
cord-259603-bh198xgl	161	3	was	be	VBD
cord-259603-bh198xgl	161	4	described	describe	VBN
cord-259603-bh198xgl	161	5	,	,	,
cord-259603-bh198xgl	161	6	and	and	CC
cord-259603-bh198xgl	161	7	also	also	RB
cord-259603-bh198xgl	161	8	visualized	visualize	VBN
cord-259603-bh198xgl	161	9	by	by	IN
cord-259603-bh198xgl	161	10	electron	electron	NN
cord-259603-bh198xgl	161	11	microscopy	microscopy	NNS
cord-259603-bh198xgl	161	12	,	,	,
cord-259603-bh198xgl	161	13	as	as	IN
cord-259603-bh198xgl	161	14	a	a	DT
cord-259603-bh198xgl	161	15	doughnut	doughnut	NN
cord-259603-bh198xgl	161	16	-	-	HYPH
cord-259603-bh198xgl	161	17	shaped	shape	VBN
cord-259603-bh198xgl	161	18	hollow	hollow	JJ
cord-259603-bh198xgl	161	19	structure	structure	NN
cord-259603-bh198xgl	161	20	of	of	IN
cord-259603-bh198xgl	161	21	which	which	WDT
cord-259603-bh198xgl	161	22	the	the	DT
cord-259603-bh198xgl	161	23	central	central	JJ
cord-259603-bh198xgl	161	24	channel	channel	NN
cord-259603-bh198xgl	161	25	is	be	VBZ
cord-259603-bh198xgl	161	26	lined	line	VBN
cord-259603-bh198xgl	161	27	with	with	IN
cord-259603-bh198xgl	161	28	positively	positively	RB
cord-259603-bh198xgl	161	29	charged	charge	VBN
cord-259603-bh198xgl	161	30	side	side	NN
cord-259603-bh198xgl	161	31	chains	chain	NNS
cord-259603-bh198xgl	161	32	(	(	-LRB-
cord-259603-bh198xgl	161	33	Fig	Fig	NNP
cord-259603-bh198xgl	161	34	.	.	.
cord-259603-bh198xgl	161	35	2A	2a	CD
cord-259603-bh198xgl	161	36	)	)	-RRB-
cord-259603-bh198xgl	161	37	.	.	.
cord-259603-bh198xgl	162	1	A	a	DT
cord-259603-bh198xgl	162	2	combination	combination	NN
cord-259603-bh198xgl	162	3	of	of	IN
cord-259603-bh198xgl	162	4	structural	structural	JJ
cord-259603-bh198xgl	162	5	modeling	modeling	NN
cord-259603-bh198xgl	162	6	,	,	,
cord-259603-bh198xgl	162	7	RNA	rna	NN
cord-259603-bh198xgl	162	8	-	-	HYPH
cord-259603-bh198xgl	162	9	binding	bind	VBG
cord-259603-bh198xgl	162	10	studies	study	NNS
cord-259603-bh198xgl	162	11	,	,	,
cord-259603-bh198xgl	162	12	and	and	CC
cord-259603-bh198xgl	162	13	site	site	NN
cord-259603-bh198xgl	162	14	-	-	HYPH
cord-259603-bh198xgl	162	15	directed	direct	VBN
cord-259603-bh198xgl	162	16	mutagenesis	mutagenesis	NN
cord-259603-bh198xgl	162	17	led	lead	VBD
cord-259603-bh198xgl	162	18	to	to	IN
cord-259603-bh198xgl	162	19	the	the	DT
cord-259603-bh198xgl	162	20	hypothesis	hypothesis	NN
cord-259603-bh198xgl	162	21	that	that	IN
cord-259603-bh198xgl	162	22	the	the	DT
cord-259603-bh198xgl	162	23	complex	complex	NN
cord-259603-bh198xgl	162	24	may	may	MD
cord-259603-bh198xgl	162	25	slide	slide	VB
cord-259603-bh198xgl	162	26	along	along	IN
cord-259603-bh198xgl	162	27	the	the	DT
cord-259603-bh198xgl	162	28	replicating	replicate	VBG
cord-259603-bh198xgl	162	29	viral	viral	JJ
cord-259603-bh198xgl	162	30	RNA	RNA	NNP
cord-259603-bh198xgl	162	31	together	together	RB
cord-259603-bh198xgl	162	32	with	with	IN
cord-259603-bh198xgl	162	33	other	other	JJ
cord-259603-bh198xgl	162	34	viral	viral	JJ
cord-259603-bh198xgl	162	35	proteins	protein	NNS
cord-259603-bh198xgl	162	36	,	,	,
cord-259603-bh198xgl	162	37	possibly	possibly	RB
cord-259603-bh198xgl	162	38	as	as	IN
cord-259603-bh198xgl	162	39	a	a	DT
cord-259603-bh198xgl	162	40	processivity	processivity	NN
cord-259603-bh198xgl	162	41	factor	factor	NN
cord-259603-bh198xgl	162	42	for	for	IN
cord-259603-bh198xgl	162	43	the	the	DT
cord-259603-bh198xgl	162	44	RdRp	RdRp	NNP
cord-259603-bh198xgl	162	45	(	(	-LRB-
cord-259603-bh198xgl	162	46	nsp12	nsp12	NNS
cord-259603-bh198xgl	162	47	;	;	:
cord-259603-bh198xgl	162	48	see	see	VB
cord-259603-bh198xgl	162	49	later	later	RB
cord-259603-bh198xgl	162	50	)	)	-RRB-
cord-259603-bh198xgl	162	51	.	.	.
cord-259603-bh198xgl	163	1	Within	within	IN
cord-259603-bh198xgl	163	2	the	the	DT
cord-259603-bh198xgl	163	3	nsp7-nsp8	nsp7-nsp8	NNP
cord-259603-bh198xgl	163	4	hexadecamer	hexadecamer	NN
cord-259603-bh198xgl	163	5	,	,	,
cord-259603-bh198xgl	163	6	SARS	SARS	NNP
cord-259603-bh198xgl	163	7	-	-	HYPH
cord-259603-bh198xgl	163	8	CoV	CoV	NNP
cord-259603-bh198xgl	163	9	nsp8	nsp8	NN
cord-259603-bh198xgl	163	10	was	be	VBD
cord-259603-bh198xgl	163	11	found	find	VBN
cord-259603-bh198xgl	163	12	to	to	TO
cord-259603-bh198xgl	163	13	adopt	adopt	VB
cord-259603-bh198xgl	163	14	two	two	CD
cord-259603-bh198xgl	163	15	different	different	JJ
cord-259603-bh198xgl	163	16	conformations	conformation	NNS
cord-259603-bh198xgl	163	17	(	(	-LRB-
cord-259603-bh198xgl	163	18	Fig	Fig	NNP
cord-259603-bh198xgl	163	19	.	.	.
cord-259603-bh198xgl	163	20	2B	2B	NNP
cord-259603-bh198xgl	163	21	and	and	CC
cord-259603-bh198xgl	163	22	C	C	NNP
cord-259603-bh198xgl	163	23	)	)	-RRB-
cord-259603-bh198xgl	163	24	.	.	.
cord-259603-bh198xgl	164	1	These	these	DT
cord-259603-bh198xgl	164	2	were	be	VBD
cord-259603-bh198xgl	164	3	named	name	VBN
cord-259603-bh198xgl	164	4	"	"	``
cord-259603-bh198xgl	164	5	golf	golf	NN
cord-259603-bh198xgl	164	6	club	club	NN
cord-259603-bh198xgl	164	7	"	"	''
cord-259603-bh198xgl	164	8	and	and	CC
cord-259603-bh198xgl	164	9	"	"	``
cord-259603-bh198xgl	164	10	golf	golf	NN
cord-259603-bh198xgl	164	11	club	club	NN
cord-259603-bh198xgl	164	12	with	with	IN
cord-259603-bh198xgl	164	13	a	a	DT
cord-259603-bh198xgl	164	14	bent	bent	JJ
cord-259603-bh198xgl	164	15	shaft	shaft	NN
cord-259603-bh198xgl	164	16	"	"	''
cord-259603-bh198xgl	165	1	(	(	-LRB-
cord-259603-bh198xgl	165	2	Zhai	Zhai	NNP
cord-259603-bh198xgl	165	3	et	et	NNP
cord-259603-bh198xgl	165	4	al	al	NNP
cord-259603-bh198xgl	165	5	.	.	NNP
cord-259603-bh198xgl	165	6	,	,	,
cord-259603-bh198xgl	165	7	2005	2005	CD
cord-259603-bh198xgl	165	8	)	)	-RRB-
cord-259603-bh198xgl	165	9	,	,	,
cord-259603-bh198xgl	165	10	with	with	IN
cord-259603-bh198xgl	165	11	the	the	DT
cord-259603-bh198xgl	165	12	globular	globular	JJ
cord-259603-bh198xgl	165	13	head	head	NN
cord-259603-bh198xgl	165	14	of	of	IN
cord-259603-bh198xgl	165	15	the	the	DT
cord-259603-bh198xgl	165	16	golf	golf	NN
cord-259603-bh198xgl	165	17	club	club	NN
cord-259603-bh198xgl	165	18	being	be	VBG
cord-259603-bh198xgl	165	19	considered	consider	VBN
cord-259603-bh198xgl	165	20	a	a	DT
cord-259603-bh198xgl	165	21	new	new	JJ
cord-259603-bh198xgl	165	22	fold	fold	NN
cord-259603-bh198xgl	165	23	.	.	.
cord-259603-bh198xgl	166	1	Although	although	IN
cord-259603-bh198xgl	166	2	the	the	DT
cord-259603-bh198xgl	166	3	structures	structure	NNS
cord-259603-bh198xgl	166	4	of	of	IN
cord-259603-bh198xgl	166	5	feline	feline	JJ
cord-259603-bh198xgl	166	6	coronavirus	coronavirus	NN
cord-259603-bh198xgl	166	7	(	(	-LRB-
cord-259603-bh198xgl	166	8	FCoV	FCoV	NNP
cord-259603-bh198xgl	166	9	)	)	-RRB-
cord-259603-bh198xgl	166	10	nsp7	nsp7	NNP
cord-259603-bh198xgl	166	11	and	and	CC
cord-259603-bh198xgl	166	12	nsp8	nsp8	NN
cord-259603-bh198xgl	166	13	were	be	VBD
cord-259603-bh198xgl	166	14	found	find	VBN
cord-259603-bh198xgl	166	15	to	to	TO
cord-259603-bh198xgl	166	16	resemble	resemble	VB
cord-259603-bh198xgl	166	17	their	-PRON-	PRP$
cord-259603-bh198xgl	166	18	SARS	SARS	NNP
cord-259603-bh198xgl	166	19	-	-	HYPH
cord-259603-bh198xgl	166	20	CoV	cov	NN
cord-259603-bh198xgl	166	21	equivalents	equivalent	NNS
cord-259603-bh198xgl	166	22	,	,	,
cord-259603-bh198xgl	166	23	they	-PRON-	PRP
cord-259603-bh198xgl	166	24	were	be	VBD
cord-259603-bh198xgl	166	25	found	find	VBN
cord-259603-bh198xgl	166	26	to	to	TO
cord-259603-bh198xgl	166	27	assemble	assemble	VB
cord-259603-bh198xgl	166	28	into	into	IN
cord-259603-bh198xgl	166	29	a	a	DT
cord-259603-bh198xgl	166	30	quite	quite	RB
cord-259603-bh198xgl	166	31	different	different	JJ
cord-259603-bh198xgl	166	32	higher	high	JJR
cord-259603-bh198xgl	166	33	-	-	HYPH
cord-259603-bh198xgl	166	34	order	order	NN
cord-259603-bh198xgl	166	35	complex	complex	NN
cord-259603-bh198xgl	166	36	,	,	,
cord-259603-bh198xgl	166	37	with	with	IN
cord-259603-bh198xgl	166	38	two	two	CD
cord-259603-bh198xgl	166	39	copies	copy	NNS
cord-259603-bh198xgl	166	40	of	of	IN
cord-259603-bh198xgl	166	41	nsp7	nsp7	NN
cord-259603-bh198xgl	166	42	and	and	CC
cord-259603-bh198xgl	166	43	a	a	DT
cord-259603-bh198xgl	166	44	single	single	JJ
cord-259603-bh198xgl	166	45	copy	copy	NN
cord-259603-bh198xgl	166	46	of	of	IN
cord-259603-bh198xgl	166	47	nsp8	nsp8	NN
cord-259603-bh198xgl	166	48	forming	form	VBG
cord-259603-bh198xgl	166	49	a	a	DT
cord-259603-bh198xgl	166	50	heterotrimer	heterotrimer	NN
cord-259603-bh198xgl	166	51	(	(	-LRB-
cord-259603-bh198xgl	166	52	Xiao	Xiao	NNP
cord-259603-bh198xgl	166	53	et	et	NNP
cord-259603-bh198xgl	166	54	al	al	NNP
cord-259603-bh198xgl	166	55	.	.	NNP
cord-259603-bh198xgl	166	56	,	,	,
cord-259603-bh198xgl	166	57	2012	2012	CD
cord-259603-bh198xgl	166	58	)	)	-RRB-
cord-259603-bh198xgl	166	59	.	.	.
cord-259603-bh198xgl	167	1	Biochemical	biochemical	JJ
cord-259603-bh198xgl	167	2	and	and	CC
cord-259603-bh198xgl	167	3	reverse	reverse	JJ
cord-259603-bh198xgl	167	4	-	-	HYPH
cord-259603-bh198xgl	167	5	genetics	genetics	NN
cord-259603-bh198xgl	167	6	studies	study	NNS
cord-259603-bh198xgl	167	7	pointed	point	VBD
cord-259603-bh198xgl	167	8	toward	toward	IN
cord-259603-bh198xgl	167	9	an	an	DT
cord-259603-bh198xgl	167	10	important	important	JJ
cord-259603-bh198xgl	167	11	role	role	NN
cord-259603-bh198xgl	167	12	in	in	IN
cord-259603-bh198xgl	167	13	RNA	RNA	NNP
cord-259603-bh198xgl	167	14	synthesis	synthesis	NN
cord-259603-bh198xgl	167	15	for	for	IN
cord-259603-bh198xgl	167	16	SARS	SARS	NNP
cord-259603-bh198xgl	167	17	-	-	HYPH
cord-259603-bh198xgl	167	18	CoV	CoV	NNP
cord-259603-bh198xgl	167	19	nsp8	nsp8	NN
cord-259603-bh198xgl	167	20	residues	residue	NNS
cord-259603-bh198xgl	167	21	K58	K58	NNP
cord-259603-bh198xgl	167	22	,	,	,
cord-259603-bh198xgl	167	23	P183	P183	NNP
cord-259603-bh198xgl	167	24	,	,	,
cord-259603-bh198xgl	167	25	and	and	CC
cord-259603-bh198xgl	167	26	R190	R190	NNP
cord-259603-bh198xgl	167	27	,	,	,
cord-259603-bh198xgl	167	28	whose	whose	WP$
cord-259603-bh198xgl	167	29	replacement	replacement	NN
cord-259603-bh198xgl	167	30	was	be	VBD
cord-259603-bh198xgl	167	31	lethal	lethal	JJ
cord-259603-bh198xgl	167	32	to	to	IN
cord-259603-bh198xgl	167	33	SARS	SARS	NNP
cord-259603-bh198xgl	167	34	-	-	HYPH
cord-259603-bh198xgl	167	35	CoV.	CoV.	NNP
cord-259603-bh198xgl	167	36	Of	of	IN
cord-259603-bh198xgl	167	37	these	these	DT
cord-259603-bh198xgl	167	38	residues	residue	NNS
cord-259603-bh198xgl	167	39	,	,	,
cord-259603-bh198xgl	167	40	P183	p183	NN
cord-259603-bh198xgl	167	41	and	and	CC
cord-259603-bh198xgl	167	42	R190	R190	NNP
cord-259603-bh198xgl	167	43	were	be	VBD
cord-259603-bh198xgl	167	44	postulated	postulate	VBN
cord-259603-bh198xgl	167	45	to	to	TO
cord-259603-bh198xgl	167	46	be	be	VB
cord-259603-bh198xgl	167	47	involved	involve	VBN
cord-259603-bh198xgl	167	48	in	in	IN
cord-259603-bh198xgl	167	49	interactions	interaction	NNS
cord-259603-bh198xgl	167	50	with	with	IN
cord-259603-bh198xgl	167	51	nsp12	nsp12	CD
cord-259603-bh198xgl	167	52	,	,	,
cord-259603-bh198xgl	167	53	whereas	whereas	IN
cord-259603-bh198xgl	167	54	K58	K58	NNP
cord-259603-bh198xgl	167	55	may	may	MD
cord-259603-bh198xgl	167	56	be	be	VB
cord-259603-bh198xgl	167	57	critical	critical	JJ
cord-259603-bh198xgl	167	58	for	for	IN
cord-259603-bh198xgl	167	59	nsp8-RNA	nsp8-RNA	NNP
cord-259603-bh198xgl	167	60	interactions	interaction	NNS
cord-259603-bh198xgl	167	61	(	(	-LRB-
cord-259603-bh198xgl	167	62	Subissi	Subissi	NNP
cord-259603-bh198xgl	167	63	et	et	NNP
cord-259603-bh198xgl	167	64	al	al	NNP
cord-259603-bh198xgl	167	65	.	.	NNP
cord-259603-bh198xgl	167	66	,	,	,
cord-259603-bh198xgl	167	67	2014b	2014b	CD
cord-259603-bh198xgl	167	68	)	)	-RRB-
cord-259603-bh198xgl	167	69	.	.	.
cord-259603-bh198xgl	168	1	Reverse	reverse	NN
cord-259603-bh198xgl	168	2	-	-	HYPH
cord-259603-bh198xgl	168	3	genetics	genetics	NN
cord-259603-bh198xgl	168	4	studies	study	NNS
cord-259603-bh198xgl	168	5	targeting	target	VBG
cord-259603-bh198xgl	168	6	the	the	DT
cord-259603-bh198xgl	168	7	3	3	CD
cord-259603-bh198xgl	168	8	0	0	CD
cord-259603-bh198xgl	168	9	-proximal	-proximal	HYPH
cord-259603-bh198xgl	168	10	RNA	RNA	NNP
cord-259603-bh198xgl	168	11	replication	replication	NN
cord-259603-bh198xgl	168	12	signals	signal	NNS
cord-259603-bh198xgl	168	13	in	in	IN
cord-259603-bh198xgl	168	14	the	the	DT
cord-259603-bh198xgl	168	15	MHV	MHV	NNP
cord-259603-bh198xgl	168	16	genome	genome	NN
cord-259603-bh198xgl	168	17	provided	provide	VBD
cord-259603-bh198xgl	168	18	strong	strong	JJ
cord-259603-bh198xgl	168	19	evidence	evidence	NN
cord-259603-bh198xgl	168	20	for	for	IN
cord-259603-bh198xgl	168	21	an	an	DT
cord-259603-bh198xgl	168	22	interaction	interaction	NN
cord-259603-bh198xgl	168	23	between	between	IN
cord-259603-bh198xgl	168	24	nsp8	nsp8	NN
cord-259603-bh198xgl	168	25	and	and	CC
cord-259603-bh198xgl	168	26	these	these	DT
cord-259603-bh198xgl	168	27	RNA	RNA	NNP
cord-259603-bh198xgl	168	28	structures	structure	NNS
cord-259603-bh198xgl	168	29	(	(	-LRB-
cord-259603-bh198xgl	168	30	a	a	DT
cord-259603-bh198xgl	168	31	so	so	RB
cord-259603-bh198xgl	168	32	-	-	HYPH
cord-259603-bh198xgl	168	33	called	call	VBN
cord-259603-bh198xgl	168	34	"	"	``
cord-259603-bh198xgl	168	35	bulged	bulge	VBN
cord-259603-bh198xgl	168	36	stemloop	stemloop	NN
cord-259603-bh198xgl	168	37	"	"	''
cord-259603-bh198xgl	168	38	and	and	CC
cord-259603-bh198xgl	168	39	RNA	RNA	NNP
cord-259603-bh198xgl	168	40	pseudoknot	pseudoknot	NNP
cord-259603-bh198xgl	168	41	)	)	-RRB-
cord-259603-bh198xgl	168	42	.	.	.
cord-259603-bh198xgl	169	1	When	when	WRB
cord-259603-bh198xgl	169	2	making	make	VBG
cord-259603-bh198xgl	169	3	a	a	DT
cord-259603-bh198xgl	169	4	particular	particular	JJ
cord-259603-bh198xgl	169	5	6-nucleotide	6-nucleotide	CD
cord-259603-bh198xgl	169	6	insertion	insertion	NN
cord-259603-bh198xgl	169	7	in	in	IN
cord-259603-bh198xgl	169	8	the	the	DT
cord-259603-bh198xgl	169	9	RNA	RNA	NNP
cord-259603-bh198xgl	169	10	pseudoknot	pseudoknot	NN
cord-259603-bh198xgl	169	11	,	,	,
cord-259603-bh198xgl	169	12	which	which	WDT
cord-259603-bh198xgl	169	13	strongly	strongly	RB
cord-259603-bh198xgl	169	14	affected	affect	VBD
cord-259603-bh198xgl	169	15	MHV	MHV	NNP
cord-259603-bh198xgl	169	16	replication	replication	NN
cord-259603-bh198xgl	169	17	,	,	,
cord-259603-bh198xgl	169	18	multiple	multiple	JJ
cord-259603-bh198xgl	169	19	suppressor	suppressor	NN
cord-259603-bh198xgl	169	20	mutations	mutation	NNS
cord-259603-bh198xgl	169	21	evolved	evolve	VBN
cord-259603-bh198xgl	169	22	,	,	,
cord-259603-bh198xgl	169	23	of	of	IN
cord-259603-bh198xgl	169	24	which	which	WDT
cord-259603-bh198xgl	169	25	several	several	JJ
cord-259603-bh198xgl	169	26	mapped	map	VBD
cord-259603-bh198xgl	169	27	to	to	IN
cord-259603-bh198xgl	169	28	the	the	DT
cord-259603-bh198xgl	169	29	genomic	genomic	JJ
cord-259603-bh198xgl	169	30	region	region	NN
cord-259603-bh198xgl	169	31	encoding	encode	VBG
cord-259603-bh198xgl	169	32	nsp8	nsp8	NN
cord-259603-bh198xgl	169	33	and	and	CC
cord-259603-bh198xgl	169	34	nsp9	nsp9	NN
cord-259603-bh198xgl	170	1	(	(	-LRB-
cord-259603-bh198xgl	170	2	Z€	Z€	NNP
cord-259603-bh198xgl	170	3	ust	ust	NNP
cord-259603-bh198xgl	170	4	et	et	NNP
cord-259603-bh198xgl	170	5	al	al	NNP
cord-259603-bh198xgl	170	6	.	.	NNP
cord-259603-bh198xgl	170	7	,	,	,
cord-259603-bh198xgl	170	8	2008	2008	CD
cord-259603-bh198xgl	170	9	)	)	-RRB-
cord-259603-bh198xgl	170	10	.	.	.
cord-259603-bh198xgl	171	1	These	these	DT
cord-259603-bh198xgl	171	2	interactions	interaction	NNS
cord-259603-bh198xgl	171	3	were	be	VBD
cord-259603-bh198xgl	171	4	postulated	postulate	VBN
cord-259603-bh198xgl	171	5	to	to	TO
cord-259603-bh198xgl	171	6	be	be	VB
cord-259603-bh198xgl	171	7	part	part	NN
cord-259603-bh198xgl	171	8	of	of	IN
cord-259603-bh198xgl	171	9	a	a	DT
cord-259603-bh198xgl	171	10	molecular	molecular	JJ
cord-259603-bh198xgl	171	11	switch	switch	NN
cord-259603-bh198xgl	171	12	that	that	WDT
cord-259603-bh198xgl	171	13	controls	control	VBZ
cord-259603-bh198xgl	171	14	minus	minus	JJ
cord-259603-bh198xgl	171	15	-	-	HYPH
cord-259603-bh198xgl	171	16	strand	strand	NN
cord-259603-bh198xgl	171	17	RNA	RNA	NNP
cord-259603-bh198xgl	171	18	synthesis	synthesis	NN
cord-259603-bh198xgl	171	19	,	,	,
cord-259603-bh198xgl	171	20	or	or	CC
cord-259603-bh198xgl	171	21	its	-PRON-	PRP$
cord-259603-bh198xgl	171	22	initiation	initiation	NN
cord-259603-bh198xgl	171	23	from	from	IN
cord-259603-bh198xgl	171	24	the	the	DT
cord-259603-bh198xgl	171	25	3	3	CD
cord-259603-bh198xgl	171	26	0	0	CD
cord-259603-bh198xgl	171	27	end	end	NN
cord-259603-bh198xgl	171	28	of	of	IN
cord-259603-bh198xgl	171	29	the	the	DT
cord-259603-bh198xgl	171	30	viral	viral	JJ
cord-259603-bh198xgl	171	31	genome	genome	NN
cord-259603-bh198xgl	171	32	(	(	-LRB-
cord-259603-bh198xgl	171	33	te	te	NNP
cord-259603-bh198xgl	171	34	Velthuis	Velthuis	NNP
cord-259603-bh198xgl	171	35	et	et	NNP
cord-259603-bh198xgl	171	36	al	al	NNP
cord-259603-bh198xgl	171	37	.	.	NNP
cord-259603-bh198xgl	171	38	,	,	,
cord-259603-bh198xgl	171	39	2012	2012	CD
cord-259603-bh198xgl	171	40	;	;	:
cord-259603-bh198xgl	171	41	Z€	Z€	NNP
cord-259603-bh198xgl	171	42	ust	ust	NNP
cord-259603-bh198xgl	171	43	et	et	NNP
cord-259603-bh198xgl	171	44	al	al	NNP
cord-259603-bh198xgl	171	45	.	.	NNP
cord-259603-bh198xgl	171	46	,	,	,
cord-259603-bh198xgl	171	47	2008	2008	CD
cord-259603-bh198xgl	171	48	)	)	-RRB-
cord-259603-bh198xgl	171	49	.	.	.
cord-259603-bh198xgl	172	1	Using	use	VBG
cord-259603-bh198xgl	172	2	screening	screening	NN
cord-259603-bh198xgl	172	3	approaches	approach	NNS
cord-259603-bh198xgl	172	4	based	base	VBN
cord-259603-bh198xgl	172	5	on	on	IN
cord-259603-bh198xgl	172	6	yeast	yeast	NN
cord-259603-bh198xgl	172	7	two	two	CD
cord-259603-bh198xgl	172	8	-	-	HYPH
cord-259603-bh198xgl	172	9	hybrid	hybrid	NN
cord-259603-bh198xgl	172	10	and	and	CC
cord-259603-bh198xgl	172	11	glutathione	glutathione	NN
cord-259603-bh198xgl	172	12	S	s	NN
cord-259603-bh198xgl	172	13	-	-	HYPH
cord-259603-bh198xgl	172	14	transferase	transferase	NN
cord-259603-bh198xgl	172	15	(	(	-LRB-
cord-259603-bh198xgl	172	16	GST	gst	NN
cord-259603-bh198xgl	172	17	)	)	-RRB-
cord-259603-bh198xgl	172	18	pull	pull	VB
cord-259603-bh198xgl	172	19	-	-	HYPH
cord-259603-bh198xgl	172	20	down	down	RP
cord-259603-bh198xgl	172	21	assays	assay	NNS
cord-259603-bh198xgl	172	22	,	,	,
cord-259603-bh198xgl	172	23	SARS	SARS	NNP
cord-259603-bh198xgl	172	24	-	-	HYPH
cord-259603-bh198xgl	172	25	CoV	CoV	NNP
cord-259603-bh198xgl	172	26	nsp8	nsp8	NN
cord-259603-bh198xgl	172	27	was	be	VBD
cord-259603-bh198xgl	172	28	reported	report	VBN
cord-259603-bh198xgl	172	29	to	to	TO
cord-259603-bh198xgl	172	30	be	be	VB
cord-259603-bh198xgl	172	31	an	an	DT
cord-259603-bh198xgl	172	32	interaction	interaction	NN
cord-259603-bh198xgl	172	33	partner	partner	NN
cord-259603-bh198xgl	172	34	of	of	IN
cord-259603-bh198xgl	172	35	many	many	JJ
cord-259603-bh198xgl	172	36	other	other	JJ
cord-259603-bh198xgl	172	37	viral	viral	JJ
cord-259603-bh198xgl	172	38	proteins	protein	NNS
cord-259603-bh198xgl	172	39	(	(	-LRB-
cord-259603-bh198xgl	172	40	including	include	VBG
cord-259603-bh198xgl	172	41	nsp2	nsp2	NN
cord-259603-bh198xgl	172	42	,	,	,
cord-259603-bh198xgl	172	43	nsp3	nsp3	NNS
cord-259603-bh198xgl	172	44	,	,	,
cord-259603-bh198xgl	172	45	and	and	CC
cord-259603-bh198xgl	172	46	nsp5	nsp5	NN
cord-259603-bh198xgl	172	47	to	to	IN
cord-259603-bh198xgl	172	48	nsp16	nsp16	NNS
cord-259603-bh198xgl	172	49	)	)	-RRB-
cord-259603-bh198xgl	172	50	,	,	,
cord-259603-bh198xgl	172	51	although	although	IN
cord-259603-bh198xgl	172	52	most	most	JJS
cord-259603-bh198xgl	172	53	of	of	IN
cord-259603-bh198xgl	172	54	these	these	DT
cord-259603-bh198xgl	172	55	interactions	interaction	NNS
cord-259603-bh198xgl	172	56	remain	remain	VBP
cord-259603-bh198xgl	172	57	to	to	TO
cord-259603-bh198xgl	172	58	be	be	VB
cord-259603-bh198xgl	172	59	verified	verify	VBN
cord-259603-bh198xgl	172	60	in	in	IN
cord-259603-bh198xgl	172	61	the	the	DT
cord-259603-bh198xgl	172	62	infected	infected	JJ
cord-259603-bh198xgl	172	63	cell	cell	NN
cord-259603-bh198xgl	172	64	(	(	-LRB-
cord-259603-bh198xgl	172	65	von	von	NNP
cord-259603-bh198xgl	172	66	Brunn	Brunn	NNP
cord-259603-bh198xgl	172	67	et	et	NNP
cord-259603-bh198xgl	172	68	al	al	NNP
cord-259603-bh198xgl	172	69	.	.	NNP
cord-259603-bh198xgl	172	70	,	,	,
cord-259603-bh198xgl	172	71	2007	2007	CD
cord-259603-bh198xgl	172	72	)	)	-RRB-
cord-259603-bh198xgl	172	73	.	.	.
cord-259603-bh198xgl	173	1	The	the	DT
cord-259603-bh198xgl	173	2	CoV	cov	NN
cord-259603-bh198xgl	173	3	nsp9	nsp9	DT
cord-259603-bh198xgl	173	4	subunit	subunit	NN
cord-259603-bh198xgl	173	5	is	be	VBZ
cord-259603-bh198xgl	173	6	about	about	RB
cord-259603-bh198xgl	173	7	110	110	CD
cord-259603-bh198xgl	173	8	amino	amino	NN
cord-259603-bh198xgl	173	9	acids	acid	NNS
cord-259603-bh198xgl	173	10	long	long	RB
cord-259603-bh198xgl	173	11	and	and	CC
cord-259603-bh198xgl	173	12	was	be	VBD
cord-259603-bh198xgl	173	13	the	the	DT
cord-259603-bh198xgl	173	14	second	second	JJ
cord-259603-bh198xgl	173	15	replicase	replicase	NN
cord-259603-bh198xgl	173	16	cleavage	cleavage	NN
cord-259603-bh198xgl	173	17	product	product	NN
cord-259603-bh198xgl	173	18	,	,	,
cord-259603-bh198xgl	173	19	after	after	IN
cord-259603-bh198xgl	173	20	nsp5	nsp5	NN
cord-259603-bh198xgl	173	21	,	,	,
cord-259603-bh198xgl	173	22	for	for	IN
cord-259603-bh198xgl	173	23	which	which	WDT
cord-259603-bh198xgl	173	24	crystal	crystal	NN
cord-259603-bh198xgl	173	25	structures	structure	NNS
cord-259603-bh198xgl	173	26	were	be	VBD
cord-259603-bh198xgl	173	27	obtained	obtain	VBN
cord-259603-bh198xgl	174	1	(	(	-LRB-
cord-259603-bh198xgl	174	2	Egloff	Egloff	NNP
cord-259603-bh198xgl	174	3	et	et	FW
cord-259603-bh198xgl	174	4	al	al	NNP
cord-259603-bh198xgl	174	5	.	.	NNP
cord-259603-bh198xgl	174	6	,	,	,
cord-259603-bh198xgl	174	7	2004	2004	CD
cord-259603-bh198xgl	175	1	;	;	:
cord-259603-bh198xgl	175	2	Sutton	Sutton	NNP
cord-259603-bh198xgl	175	3	et	et	NNP
cord-259603-bh198xgl	175	4	al	al	NNP
cord-259603-bh198xgl	175	5	.	.	NNP
cord-259603-bh198xgl	175	6	,	,	,
cord-259603-bh198xgl	175	7	2004	2004	CD
cord-259603-bh198xgl	175	8	)	)	-RRB-
cord-259603-bh198xgl	175	9	.	.	.
cord-259603-bh198xgl	176	1	The	the	DT
cord-259603-bh198xgl	176	2	biologically	biologically	RB
cord-259603-bh198xgl	176	3	active	active	JJ
cord-259603-bh198xgl	176	4	form	form	NN
cord-259603-bh198xgl	176	5	of	of	IN
cord-259603-bh198xgl	176	6	the	the	DT
cord-259603-bh198xgl	176	7	protein	protein	NN
cord-259603-bh198xgl	176	8	is	be	VBZ
cord-259603-bh198xgl	176	9	believed	believe	VBN
cord-259603-bh198xgl	176	10	to	to	TO
cord-259603-bh198xgl	176	11	be	be	VB
cord-259603-bh198xgl	176	12	a	a	DT
cord-259603-bh198xgl	176	13	dimer	dimer	NN
cord-259603-bh198xgl	176	14	that	that	WDT
cord-259603-bh198xgl	176	15	is	be	VBZ
cord-259603-bh198xgl	176	16	capable	capable	JJ
cord-259603-bh198xgl	176	17	of	of	IN
cord-259603-bh198xgl	176	18	binding	bind	VBG
cord-259603-bh198xgl	176	19	nucleic	nucleic	JJ
cord-259603-bh198xgl	176	20	acids	acid	NNS
cord-259603-bh198xgl	176	21	in	in	IN
cord-259603-bh198xgl	176	22	a	a	DT
cord-259603-bh198xgl	176	23	nonsequence	nonsequence	NN
cord-259603-bh198xgl	176	24	-	-	HYPH
cord-259603-bh198xgl	176	25	specific	specific	JJ
cord-259603-bh198xgl	176	26	manner	manner	NN
cord-259603-bh198xgl	176	27	,	,	,
cord-259603-bh198xgl	176	28	with	with	IN
cord-259603-bh198xgl	176	29	an	an	DT
cord-259603-bh198xgl	176	30	apparent	apparent	JJ
cord-259603-bh198xgl	176	31	preference	preference	NN
cord-259603-bh198xgl	176	32	for	for	IN
cord-259603-bh198xgl	176	33	single	single	RB
cord-259603-bh198xgl	176	34	-	-	HYPH
cord-259603-bh198xgl	176	35	stranded	strand	VBN
cord-259603-bh198xgl	176	36	RNA	rna	NN
cord-259603-bh198xgl	177	1	(	(	-LRB-
cord-259603-bh198xgl	177	2	Egloff	Egloff	NNP
cord-259603-bh198xgl	177	3	et	et	FW
cord-259603-bh198xgl	177	4	al	al	NNP
cord-259603-bh198xgl	177	5	.	.	.
cord-259603-bh198xgl	178	1	,	,	,
cord-259603-bh198xgl	178	2	2004	2004	CD
cord-259603-bh198xgl	178	3	;	;	:
cord-259603-bh198xgl	178	4	Ponnusamy	Ponnusamy	NNP
cord-259603-bh198xgl	178	5	et	et	NNP
cord-259603-bh198xgl	178	6	al	al	NNP
cord-259603-bh198xgl	178	7	.	.	NNP
cord-259603-bh198xgl	178	8	,	,	,
cord-259603-bh198xgl	178	9	2008	2008	CD
cord-259603-bh198xgl	179	1	;	;	:
cord-259603-bh198xgl	179	2	Sutton	Sutton	NNP
cord-259603-bh198xgl	179	3	et	et	NNP
cord-259603-bh198xgl	179	4	al	al	NNP
cord-259603-bh198xgl	179	5	.	.	NNP
cord-259603-bh198xgl	179	6	,	,	,
cord-259603-bh198xgl	179	7	2004	2004	CD
cord-259603-bh198xgl	179	8	)	)	-RRB-
cord-259603-bh198xgl	179	9	.	.	.
cord-259603-bh198xgl	180	1	Several	several	JJ
cord-259603-bh198xgl	180	2	nsp9	nsp9	NNP
cord-259603-bh198xgl	180	3	point	point	NN
cord-259603-bh198xgl	180	4	mutations	mutation	NNS
cord-259603-bh198xgl	180	5	that	that	WDT
cord-259603-bh198xgl	180	6	block	block	VBP
cord-259603-bh198xgl	180	7	CoV	cov	NN
cord-259603-bh198xgl	180	8	replication	replication	NN
cord-259603-bh198xgl	180	9	have	have	VBP
cord-259603-bh198xgl	180	10	now	now	RB
cord-259603-bh198xgl	180	11	been	be	VBN
cord-259603-bh198xgl	180	12	described	describe	VBN
cord-259603-bh198xgl	181	1	(	(	-LRB-
cord-259603-bh198xgl	181	2	Chen	Chen	NNP
cord-259603-bh198xgl	181	3	et	et	NNP
cord-259603-bh198xgl	181	4	al	al	NNP
cord-259603-bh198xgl	181	5	.	.	.
cord-259603-bh198xgl	182	1	,	,	,
cord-259603-bh198xgl	182	2	2009a	2009a	CD
cord-259603-bh198xgl	182	3	;	;	:
cord-259603-bh198xgl	182	4	Miknis	Miknis	NNP
cord-259603-bh198xgl	182	5	et	et	NNP
cord-259603-bh198xgl	182	6	al	al	NNP
cord-259603-bh198xgl	182	7	.	.	NNP
cord-259603-bh198xgl	182	8	,	,	,
cord-259603-bh198xgl	182	9	2009	2009	CD
cord-259603-bh198xgl	182	10	)	)	-RRB-
cord-259603-bh198xgl	182	11	,	,	,
cord-259603-bh198xgl	182	12	but	but	CC
cord-259603-bh198xgl	182	13	the	the	DT
cord-259603-bh198xgl	182	14	protein	protein	NN
cord-259603-bh198xgl	182	15	's	's	POS
cord-259603-bh198xgl	182	16	exact	exact	JJ
cord-259603-bh198xgl	182	17	function	function	NN
cord-259603-bh198xgl	182	18	has	have	VBZ
cord-259603-bh198xgl	182	19	remained	remain	VBN
cord-259603-bh198xgl	182	20	enigmatic	enigmatic	JJ
cord-259603-bh198xgl	182	21	thus	thus	RB
cord-259603-bh198xgl	182	22	far	far	RB
cord-259603-bh198xgl	182	23	.	.	.
cord-259603-bh198xgl	183	1	The	the	DT
cord-259603-bh198xgl	183	2	nsp9	nsp9	DT
cord-259603-bh198xgl	183	3	monomer	monomer	NN
cord-259603-bh198xgl	183	4	consists	consist	VBZ
cord-259603-bh198xgl	183	5	of	of	IN
cord-259603-bh198xgl	183	6	a	a	DT
cord-259603-bh198xgl	183	7	β	β	NN
cord-259603-bh198xgl	183	8	-	-	HYPH
cord-259603-bh198xgl	183	9	barrel	barrel	NN
cord-259603-bh198xgl	183	10	,	,	,
cord-259603-bh198xgl	183	11	composed	compose	VBN
cord-259603-bh198xgl	183	12	of	of	IN
cord-259603-bh198xgl	183	13	seven	seven	CD
cord-259603-bh198xgl	183	14	β	β	NN
cord-259603-bh198xgl	183	15	-	-	HYPH
cord-259603-bh198xgl	183	16	strands	strand	NNS
cord-259603-bh198xgl	183	17	,	,	,
cord-259603-bh198xgl	183	18	and	and	CC
cord-259603-bh198xgl	183	19	a	a	DT
cord-259603-bh198xgl	183	20	C	c	NN
cord-259603-bh198xgl	183	21	-	-	HYPH
cord-259603-bh198xgl	183	22	terminal	terminal	NN
cord-259603-bh198xgl	183	23	domain	domain	NN
cord-259603-bh198xgl	183	24	formed	form	VBN
cord-259603-bh198xgl	183	25	by	by	IN
cord-259603-bh198xgl	183	26	a	a	DT
cord-259603-bh198xgl	183	27	single	single	JJ
cord-259603-bh198xgl	183	28	α	α	NN
cord-259603-bh198xgl	183	29	-	-	HYPH
cord-259603-bh198xgl	183	30	helix	helix	NN
cord-259603-bh198xgl	183	31	.	.	.
cord-259603-bh198xgl	184	1	The	the	DT
cord-259603-bh198xgl	184	2	latter	latter	JJ
cord-259603-bh198xgl	184	3	domain	domain	NN
cord-259603-bh198xgl	184	4	plays	play	VBZ
cord-259603-bh198xgl	184	5	a	a	DT
cord-259603-bh198xgl	184	6	key	key	JJ
cord-259603-bh198xgl	184	7	role	role	NN
cord-259603-bh198xgl	184	8	in	in	IN
cord-259603-bh198xgl	184	9	the	the	DT
cord-259603-bh198xgl	184	10	formation	formation	NN
cord-259603-bh198xgl	184	11	of	of	IN
cord-259603-bh198xgl	184	12	the	the	DT
cord-259603-bh198xgl	184	13	parallel	parallel	JJ
cord-259603-bh198xgl	184	14	helix	helix	NN
cord-259603-bh198xgl	184	15	-	-	HYPH
cord-259603-bh198xgl	184	16	helix	helix	NN
cord-259603-bh198xgl	184	17	dimer	dimer	NN
cord-259603-bh198xgl	184	18	conformation	conformation	NN
cord-259603-bh198xgl	184	19	that	that	WDT
cord-259603-bh198xgl	184	20	-	-	HYPH
cord-259603-bh198xgl	184	21	based	base	VBN
cord-259603-bh198xgl	184	22	on	on	IN
cord-259603-bh198xgl	184	23	sequence	sequence	NN
cord-259603-bh198xgl	184	24	conservation	conservation	NN
cord-259603-bh198xgl	184	25	,	,	,
cord-259603-bh198xgl	184	26	structural	structural	JJ
cord-259603-bh198xgl	184	27	considerations	consideration	NNS
cord-259603-bh198xgl	184	28	,	,	,
cord-259603-bh198xgl	184	29	and	and	CC
cord-259603-bh198xgl	184	30	experimental	experimental	JJ
cord-259603-bh198xgl	184	31	data	datum	NNS
cord-259603-bh198xgl	184	32	(	(	-LRB-
cord-259603-bh198xgl	184	33	Miknis	Miknis	NNP
cord-259603-bh198xgl	184	34	et	et	NNP
cord-259603-bh198xgl	184	35	al	al	NNP
cord-259603-bh198xgl	184	36	.	.	NNP
cord-259603-bh198xgl	184	37	,	,	,
cord-259603-bh198xgl	184	38	2009	2009	CD
cord-259603-bh198xgl	184	39	)	)	-RRB-
cord-259603-bh198xgl	185	1	-is	-is	:
cord-259603-bh198xgl	185	2	thought	think	VBN
cord-259603-bh198xgl	185	3	to	to	TO
cord-259603-bh198xgl	185	4	be	be	VB
cord-259603-bh198xgl	185	5	the	the	DT
cord-259603-bh198xgl	185	6	biologically	biologically	RB
cord-259603-bh198xgl	185	7	most	most	RBS
cord-259603-bh198xgl	185	8	relevant	relevant	JJ
cord-259603-bh198xgl	185	9	state	state	NN
cord-259603-bh198xgl	185	10	of	of	IN
cord-259603-bh198xgl	185	11	SARS	SARS	NNP
cord-259603-bh198xgl	185	12	-	-	HYPH
cord-259603-bh198xgl	185	13	CoV	CoV	NNP
cord-259603-bh198xgl	185	14	nsp9	nsp9	NNP
cord-259603-bh198xgl	185	15	.	.	.
cord-259603-bh198xgl	186	1	Nevertheless	nevertheless	RB
cord-259603-bh198xgl	186	2	,	,	,
cord-259603-bh198xgl	186	3	multiple	multiple	JJ
cord-259603-bh198xgl	186	4	alternative	alternative	JJ
cord-259603-bh198xgl	186	5	structures	structure	NNS
cord-259603-bh198xgl	186	6	were	be	VBD
cord-259603-bh198xgl	186	7	described	describe	VBN
cord-259603-bh198xgl	186	8	,	,	,
cord-259603-bh198xgl	186	9	including	include	VBG
cord-259603-bh198xgl	186	10	a	a	DT
cord-259603-bh198xgl	186	11	SARS	SARS	NNP
cord-259603-bh198xgl	186	12	-	-	HYPH
cord-259603-bh198xgl	186	13	CoV	cov	NN
cord-259603-bh198xgl	186	14	form	form	NN
cord-259603-bh198xgl	186	15	that	that	WDT
cord-259603-bh198xgl	186	16	is	be	VBZ
cord-259603-bh198xgl	186	17	stabilized	stabilize	VBN
cord-259603-bh198xgl	186	18	by	by	IN
cord-259603-bh198xgl	186	19	β	β	NN
cord-259603-bh198xgl	186	20	-	-	HYPH
cord-259603-bh198xgl	186	21	sheet	sheet	NN
cord-259603-bh198xgl	186	22	interactions	interaction	NNS
cord-259603-bh198xgl	186	23	(	(	-LRB-
cord-259603-bh198xgl	186	24	Sutton	Sutton	NNP
cord-259603-bh198xgl	186	25	et	et	NNP
cord-259603-bh198xgl	186	26	al	al	NNP
cord-259603-bh198xgl	186	27	.	.	NNP
cord-259603-bh198xgl	186	28	,	,	,
cord-259603-bh198xgl	186	29	2004	2004	CD
cord-259603-bh198xgl	186	30	)	)	-RRB-
cord-259603-bh198xgl	186	31	and	and	CC
cord-259603-bh198xgl	186	32	,	,	,
cord-259603-bh198xgl	186	33	for	for	IN
cord-259603-bh198xgl	186	34	HCoV-229E	HCoV-229E	NNP
cord-259603-bh198xgl	186	35	nsp9	nsp9	NNP
cord-259603-bh198xgl	186	36	,	,	,
cord-259603-bh198xgl	186	37	an	an	DT
cord-259603-bh198xgl	186	38	antiparallel	antiparallel	JJ
cord-259603-bh198xgl	186	39	helix	helix	NN
cord-259603-bh198xgl	186	40	-	-	HYPH
cord-259603-bh198xgl	186	41	helix	helix	NN
cord-259603-bh198xgl	186	42	dimer	dimer	NN
cord-259603-bh198xgl	186	43	that	that	WDT
cord-259603-bh198xgl	186	44	is	be	VBZ
cord-259603-bh198xgl	186	45	stabilized	stabilize	VBN
cord-259603-bh198xgl	186	46	by	by	IN
cord-259603-bh198xgl	186	47	a	a	DT
cord-259603-bh198xgl	186	48	disulfide	disulfide	JJ
cord-259603-bh198xgl	186	49	bond	bond	NN
cord-259603-bh198xgl	186	50	(	(	-LRB-
cord-259603-bh198xgl	186	51	Ponnusamy	Ponnusamy	NNP
cord-259603-bh198xgl	186	52	et	et	NNP
cord-259603-bh198xgl	186	53	al	al	NNP
cord-259603-bh198xgl	186	54	.	.	NNP
cord-259603-bh198xgl	186	55	,	,	,
cord-259603-bh198xgl	186	56	2008	2008	CD
cord-259603-bh198xgl	186	57	)	)	-RRB-
cord-259603-bh198xgl	186	58	.	.	.
cord-259603-bh198xgl	187	1	Replacement	replacement	NN
cord-259603-bh198xgl	187	2	of	of	IN
cord-259603-bh198xgl	187	3	the	the	DT
cord-259603-bh198xgl	187	4	HCoV-229E	HCoV-229E	NNP
cord-259603-bh198xgl	187	5	Cys	Cys	NNP
cord-259603-bh198xgl	187	6	residue	residue	NN
cord-259603-bh198xgl	187	7	involved	involve	VBN
cord-259603-bh198xgl	187	8	in	in	IN
cord-259603-bh198xgl	187	9	dimerization	dimerization	NN
cord-259603-bh198xgl	187	10	(	(	-LRB-
cord-259603-bh198xgl	187	11	Cys-69	Cys-69	NNP
cord-259603-bh198xgl	187	12	)	)	-RRB-
cord-259603-bh198xgl	187	13	resulted	result	VBD
cord-259603-bh198xgl	187	14	in	in	IN
cord-259603-bh198xgl	187	15	conversion	conversion	NN
cord-259603-bh198xgl	187	16	to	to	IN
cord-259603-bh198xgl	187	17	the	the	DT
cord-259603-bh198xgl	187	18	parallel	parallel	JJ
cord-259603-bh198xgl	187	19	helix	helix	NN
cord-259603-bh198xgl	187	20	-	-	HYPH
cord-259603-bh198xgl	187	21	helix	helix	NN
cord-259603-bh198xgl	187	22	dimer	dimer	NN
cord-259603-bh198xgl	187	23	described	describe	VBN
cord-259603-bh198xgl	187	24	for	for	IN
cord-259603-bh198xgl	187	25	SARS	SARS	NNP
cord-259603-bh198xgl	187	26	-	-	HYPH
cord-259603-bh198xgl	187	27	CoV	CoV	NNP
cord-259603-bh198xgl	187	28	nsp9	nsp9	NNP
cord-259603-bh198xgl	187	29	.	.	.
cord-259603-bh198xgl	188	1	Whereas	whereas	IN
cord-259603-bh198xgl	188	2	wild	wild	JJ
cord-259603-bh198xgl	188	3	-	-	HYPH
cord-259603-bh198xgl	188	4	type	type	NN
cord-259603-bh198xgl	188	5	HCoV-229E	HCoV-229E	NNP
cord-259603-bh198xgl	188	6	nsp9	nsp9	NNP
cord-259603-bh198xgl	188	7	is	be	VBZ
cord-259603-bh198xgl	188	8	organized	organize	VBN
cord-259603-bh198xgl	188	9	as	as	IN
cord-259603-bh198xgl	188	10	a	a	DT
cord-259603-bh198xgl	188	11	trimer	trimer	NN
cord-259603-bh198xgl	188	12	of	of	IN
cord-259603-bh198xgl	188	13	dimers	dimer	NNS
cord-259603-bh198xgl	188	14	,	,	,
cord-259603-bh198xgl	188	15	the	the	DT
cord-259603-bh198xgl	188	16	Cys-69	Cys-69	NNP
cord-259603-bh198xgl	188	17	!	!	.
cord-259603-bh198xgl	189	1	Ala	Ala	NNP
cord-259603-bh198xgl	189	2	mutant	mutant	JJ
cord-259603-bh198xgl	189	3	and	and	CC
cord-259603-bh198xgl	189	4	SARS	SARS	NNP
cord-259603-bh198xgl	189	5	-	-	HYPH
cord-259603-bh198xgl	189	6	CoV	CoV	NNP
cord-259603-bh198xgl	189	7	nsp9	nsp9	NNP
cord-259603-bh198xgl	189	8	both	both	DT
cord-259603-bh198xgl	189	9	form	form	NN
cord-259603-bh198xgl	189	10	rod	rod	NN
cord-259603-bh198xgl	189	11	-	-	HYPH
cord-259603-bh198xgl	189	12	like	like	JJ
cord-259603-bh198xgl	189	13	polymers	polymer	NNS
cord-259603-bh198xgl	189	14	(	(	-LRB-
cord-259603-bh198xgl	189	15	Ponnusamy	Ponnusamy	NNP
cord-259603-bh198xgl	189	16	et	et	NNP
cord-259603-bh198xgl	189	17	al	al	NNP
cord-259603-bh198xgl	189	18	.	.	NNP
cord-259603-bh198xgl	189	19	,	,	,
cord-259603-bh198xgl	189	20	2008	2008	CD
cord-259603-bh198xgl	189	21	)	)	-RRB-
cord-259603-bh198xgl	189	22	.	.	.
cord-259603-bh198xgl	190	1	Disulfide	disulfide	JJ
cord-259603-bh198xgl	190	2	bonding	bonding	NN
cord-259603-bh198xgl	190	3	of	of	IN
cord-259603-bh198xgl	190	4	the	the	DT
cord-259603-bh198xgl	190	5	latter	latter	JJ
cord-259603-bh198xgl	190	6	protein	protein	NN
cord-259603-bh198xgl	190	7	could	could	MD
cord-259603-bh198xgl	190	8	not	not	RB
cord-259603-bh198xgl	190	9	be	be	VB
cord-259603-bh198xgl	190	10	detected	detect	VBN
cord-259603-bh198xgl	191	1	(	(	-LRB-
cord-259603-bh198xgl	191	2	Miknis	Miknis	NNP
cord-259603-bh198xgl	191	3	et	et	NNP
cord-259603-bh198xgl	191	4	al	al	NNP
cord-259603-bh198xgl	191	5	.	.	NNP
cord-259603-bh198xgl	191	6	,	,	,
cord-259603-bh198xgl	191	7	2009	2009	CD
cord-259603-bh198xgl	191	8	)	)	-RRB-
cord-259603-bh198xgl	191	9	.	.	.
cord-259603-bh198xgl	192	1	Although	although	IN
cord-259603-bh198xgl	192	2	SARS	SARS	NNP
cord-259603-bh198xgl	192	3	-	-	HYPH
cord-259603-bh198xgl	192	4	CoV	CoV	NNP
cord-259603-bh198xgl	192	5	and	and	CC
cord-259603-bh198xgl	192	6	other	other	JJ
cord-259603-bh198xgl	192	7	betacoronaviruses	betacoronaviruse	NNS
cord-259603-bh198xgl	192	8	do	do	VBP
cord-259603-bh198xgl	192	9	contain	contain	VB
cord-259603-bh198xgl	192	10	an	an	DT
cord-259603-bh198xgl	192	11	equivalent	equivalent	JJ
cord-259603-bh198xgl	192	12	Cys	Cys	NNP
cord-259603-bh198xgl	192	13	residue	residue	NN
cord-259603-bh198xgl	192	14	,	,	,
cord-259603-bh198xgl	192	15	the	the	DT
cord-259603-bh198xgl	192	16	feature	feature	NN
cord-259603-bh198xgl	192	17	is	be	VBZ
cord-259603-bh198xgl	192	18	not	not	RB
cord-259603-bh198xgl	192	19	conserved	conserve	VBN
cord-259603-bh198xgl	192	20	in	in	IN
cord-259603-bh198xgl	192	21	alphacoronaviruses	alphacoronaviruse	NNS
cord-259603-bh198xgl	192	22	that	that	WDT
cord-259603-bh198xgl	192	23	are	be	VBP
cord-259603-bh198xgl	192	24	much	much	RB
cord-259603-bh198xgl	192	25	more	more	RBR
cord-259603-bh198xgl	192	26	closely	closely	RB
cord-259603-bh198xgl	192	27	related	related	JJ
cord-259603-bh198xgl	192	28	to	to	IN
cord-259603-bh198xgl	192	29	HCoV-229E.	HCoV-229E.	NNP
cord-259603-bh198xgl	193	1	Thus	thus	RB
cord-259603-bh198xgl	193	2	,	,	,
cord-259603-bh198xgl	193	3	it	-PRON-	PRP
cord-259603-bh198xgl	193	4	can	can	MD
cord-259603-bh198xgl	193	5	not	not	RB
cord-259603-bh198xgl	193	6	be	be	VB
cord-259603-bh198xgl	193	7	excluded	exclude	VBN
cord-259603-bh198xgl	193	8	that	that	IN
cord-259603-bh198xgl	193	9	the	the	DT
cord-259603-bh198xgl	193	10	disulfide	disulfide	RB
cord-259603-bh198xgl	193	11	-	-	HYPH
cord-259603-bh198xgl	193	12	bonded	bond	VBN
cord-259603-bh198xgl	193	13	form	form	NN
cord-259603-bh198xgl	193	14	of	of	IN
cord-259603-bh198xgl	193	15	HCoV-229E	HCoV-229E	NNP
cord-259603-bh198xgl	193	16	nsp9	nsp9	NNP
cord-259603-bh198xgl	193	17	is	be	VBZ
cord-259603-bh198xgl	193	18	an	an	DT
cord-259603-bh198xgl	193	19	artifact	artifact	NN
cord-259603-bh198xgl	193	20	of	of	IN
cord-259603-bh198xgl	193	21	recombinant	recombinant	JJ
cord-259603-bh198xgl	193	22	protein	protein	NN
cord-259603-bh198xgl	193	23	purification	purification	NN
cord-259603-bh198xgl	193	24	and	and	CC
cord-259603-bh198xgl	193	25	crystallization	crystallization	NN
cord-259603-bh198xgl	193	26	,	,	,
cord-259603-bh198xgl	193	27	although	although	IN
cord-259603-bh198xgl	193	28	it	-PRON-	PRP
cord-259603-bh198xgl	193	29	was	be	VBD
cord-259603-bh198xgl	193	30	suggested	suggest	VBN
cord-259603-bh198xgl	193	31	that	that	IN
cord-259603-bh198xgl	193	32	oxidative	oxidative	JJ
cord-259603-bh198xgl	193	33	stress	stress	NN
cord-259603-bh198xgl	193	34	due	due	IN
cord-259603-bh198xgl	193	35	to	to	IN
cord-259603-bh198xgl	193	36	viral	viral	JJ
cord-259603-bh198xgl	193	37	infection	infection	NN
cord-259603-bh198xgl	193	38	may	may	MD
cord-259603-bh198xgl	193	39	favor	favor	VB
cord-259603-bh198xgl	193	40	its	-PRON-	PRP$
cord-259603-bh198xgl	193	41	formation	formation	NN
cord-259603-bh198xgl	193	42	in	in	IN
cord-259603-bh198xgl	193	43	CoV	cov	NN
cord-259603-bh198xgl	193	44	-	-	HYPH
cord-259603-bh198xgl	193	45	infected	infect	VBN
cord-259603-bh198xgl	193	46	cells	cell	NNS
cord-259603-bh198xgl	194	1	(	(	-LRB-
cord-259603-bh198xgl	194	2	Ponnusamy	Ponnusamy	NNP
cord-259603-bh198xgl	194	3	et	et	NNP
cord-259603-bh198xgl	194	4	al	al	NNP
cord-259603-bh198xgl	194	5	.	.	NNP
cord-259603-bh198xgl	194	6	,	,	,
cord-259603-bh198xgl	194	7	2008	2008	CD
cord-259603-bh198xgl	194	8	)	)	-RRB-
cord-259603-bh198xgl	194	9	.	.	.
cord-259603-bh198xgl	195	1	We	-PRON-	PRP
cord-259603-bh198xgl	195	2	are	be	VBP
cord-259603-bh198xgl	195	3	not	not	RB
cord-259603-bh198xgl	195	4	aware	aware	JJ
cord-259603-bh198xgl	195	5	of	of	IN
cord-259603-bh198xgl	195	6	experiments	experiment	NNS
cord-259603-bh198xgl	195	7	directly	directly	RB
cord-259603-bh198xgl	195	8	addressing	address	VBG
cord-259603-bh198xgl	195	9	the	the	DT
cord-259603-bh198xgl	195	10	existence	existence	NN
cord-259603-bh198xgl	195	11	of	of	IN
cord-259603-bh198xgl	195	12	such	such	PDT
cord-259603-bh198xgl	195	13	a	a	DT
cord-259603-bh198xgl	195	14	disulfide	disulfide	NN
cord-259603-bh198xgl	195	15	-	-	HYPH
cord-259603-bh198xgl	195	16	linked	link	VBN
cord-259603-bh198xgl	195	17	nsp9	nsp9	DT
cord-259603-bh198xgl	195	18	dimer	dimer	NN
cord-259603-bh198xgl	195	19	in	in	IN
cord-259603-bh198xgl	195	20	CoVinfected	CoVinfected	NNP
cord-259603-bh198xgl	195	21	cells	cell	NNS
cord-259603-bh198xgl	195	22	.	.	.
cord-259603-bh198xgl	196	1	The	the	DT
cord-259603-bh198xgl	196	2	importance	importance	NN
cord-259603-bh198xgl	196	3	of	of	IN
cord-259603-bh198xgl	196	4	nsp9	nsp9	DT
cord-259603-bh198xgl	196	5	dimerization	dimerization	NN
cord-259603-bh198xgl	196	6	for	for	IN
cord-259603-bh198xgl	196	7	SARS	SARS	NNP
cord-259603-bh198xgl	196	8	-	-	HYPH
cord-259603-bh198xgl	196	9	CoV	CoV	NNP
cord-259603-bh198xgl	196	10	and	and	CC
cord-259603-bh198xgl	196	11	IBV	IBV	NNP
cord-259603-bh198xgl	196	12	viability	viability	NN
cord-259603-bh198xgl	196	13	was	be	VBD
cord-259603-bh198xgl	196	14	demonstrated	demonstrate	VBN
cord-259603-bh198xgl	196	15	in	in	IN
cord-259603-bh198xgl	196	16	reverse	reverse	JJ
cord-259603-bh198xgl	196	17	-	-	HYPH
cord-259603-bh198xgl	196	18	genetics	genetics	NN
cord-259603-bh198xgl	196	19	studies	study	NNS
cord-259603-bh198xgl	196	20	(	(	-LRB-
cord-259603-bh198xgl	197	1	Chen	Chen	NNP
cord-259603-bh198xgl	197	2	et	et	NNP
cord-259603-bh198xgl	197	3	al	al	NNP
cord-259603-bh198xgl	197	4	.	.	.
cord-259603-bh198xgl	198	1	,	,	,
cord-259603-bh198xgl	198	2	2009a	2009a	CD
cord-259603-bh198xgl	198	3	;	;	:
cord-259603-bh198xgl	198	4	Miknis	Miknis	NNP
cord-259603-bh198xgl	198	5	et	et	NNP
cord-259603-bh198xgl	198	6	al	al	NNP
cord-259603-bh198xgl	198	7	.	.	NNP
cord-259603-bh198xgl	198	8	,	,	,
cord-259603-bh198xgl	198	9	2009	2009	CD
cord-259603-bh198xgl	198	10	)	)	-RRB-
cord-259603-bh198xgl	198	11	that	that	WDT
cord-259603-bh198xgl	198	12	also	also	RB
cord-259603-bh198xgl	198	13	independently	independently	RB
cord-259603-bh198xgl	198	14	confirmed	confirm	VBD
cord-259603-bh198xgl	198	15	the	the	DT
cord-259603-bh198xgl	198	16	importance	importance	NN
cord-259603-bh198xgl	198	17	of	of	IN
cord-259603-bh198xgl	198	18	dimerization	dimerization	NN
cord-259603-bh198xgl	198	19	of	of	IN
cord-259603-bh198xgl	198	20	the	the	DT
cord-259603-bh198xgl	198	21	α	α	NN
cord-259603-bh198xgl	198	22	-	-	HYPH
cord-259603-bh198xgl	198	23	helical	helical	JJ
cord-259603-bh198xgl	198	24	domain	domain	NN
cord-259603-bh198xgl	198	25	and	and	CC
cord-259603-bh198xgl	198	26	in	in	IN
cord-259603-bh198xgl	198	27	particular	particular	JJ
cord-259603-bh198xgl	198	28	a	a	DT
cord-259603-bh198xgl	198	29	putative	putative	JJ
cord-259603-bh198xgl	198	30	GxxxG	GxxxG	NNP
cord-259603-bh198xgl	198	31	proteinprotein	proteinprotein	NN
cord-259603-bh198xgl	198	32	interaction	interaction	NN
cord-259603-bh198xgl	198	33	motif	motif	NN
cord-259603-bh198xgl	198	34	.	.	.
cord-259603-bh198xgl	199	1	Although	although	IN
cord-259603-bh198xgl	199	2	RNA	RNA	NNP
cord-259603-bh198xgl	199	3	binding	bind	VBG
cord-259603-bh198xgl	199	4	in	in	IN
cord-259603-bh198xgl	199	5	vitro	vitro	FW
cord-259603-bh198xgl	199	6	was	be	VBD
cord-259603-bh198xgl	199	7	not	not	RB
cord-259603-bh198xgl	199	8	disrupted	disrupt	VBN
cord-259603-bh198xgl	199	9	in	in	IN
cord-259603-bh198xgl	199	10	dimerization	dimerization	NN
cord-259603-bh198xgl	199	11	-	-	HYPH
cord-259603-bh198xgl	199	12	incompetent	incompetent	JJ
cord-259603-bh198xgl	199	13	SARS	SARS	NNP
cord-259603-bh198xgl	199	14	-	-	HYPH
cord-259603-bh198xgl	199	15	CoV	CoV	NNP
cord-259603-bh198xgl	199	16	nsp9	nsp9	NNP
cord-259603-bh198xgl	199	17	variants	variant	NNS
cord-259603-bh198xgl	199	18	,	,	,
cord-259603-bh198xgl	199	19	their	-PRON-	PRP$
cord-259603-bh198xgl	199	20	affinity	affinity	NN
cord-259603-bh198xgl	199	21	for	for	IN
cord-259603-bh198xgl	199	22	ssRNA	ssRNA	VBG
cord-259603-bh198xgl	199	23	20-mers	20-mers	CD
cord-259603-bh198xgl	199	24	was	be	VBD
cord-259603-bh198xgl	199	25	reduced	reduce	VBN
cord-259603-bh198xgl	199	26	by	by	IN
cord-259603-bh198xgl	199	27	5-to	5-to	CD
cord-259603-bh198xgl	199	28	12-fold	12-fold	CD
cord-259603-bh198xgl	199	29	compared	compare	VBN
cord-259603-bh198xgl	199	30	to	to	IN
cord-259603-bh198xgl	199	31	the	the	DT
cord-259603-bh198xgl	199	32	wild	wild	JJ
cord-259603-bh198xgl	199	33	-	-	HYPH
cord-259603-bh198xgl	199	34	type	type	NN
cord-259603-bh198xgl	199	35	protein	protein	NN
cord-259603-bh198xgl	199	36	(	(	-LRB-
cord-259603-bh198xgl	199	37	Miknis	Miknis	NNP
cord-259603-bh198xgl	199	38	et	et	NNP
cord-259603-bh198xgl	199	39	al	al	NNP
cord-259603-bh198xgl	199	40	.	.	NNP
cord-259603-bh198xgl	199	41	,	,	,
cord-259603-bh198xgl	199	42	2009	2009	CD
cord-259603-bh198xgl	199	43	)	)	-RRB-
cord-259603-bh198xgl	199	44	.	.	.
cord-259603-bh198xgl	200	1	Replacement	replacement	NN
cord-259603-bh198xgl	200	2	of	of	IN
cord-259603-bh198xgl	200	3	some	some	DT
cord-259603-bh198xgl	200	4	of	of	IN
cord-259603-bh198xgl	200	5	the	the	DT
cord-259603-bh198xgl	200	6	basic	basic	JJ
cord-259603-bh198xgl	200	7	residues	residue	NNS
cord-259603-bh198xgl	200	8	(	(	-LRB-
cord-259603-bh198xgl	200	9	e.g.	e.g.	RB
cord-259603-bh198xgl	200	10	,	,	,
cord-259603-bh198xgl	200	11	Lys-10	Lys-10	NNP
cord-259603-bh198xgl	200	12	,	,	,
cord-259603-bh198xgl	200	13	Lys-51	Lys-51	NNP
cord-259603-bh198xgl	200	14	,	,	,
cord-259603-bh198xgl	200	15	and	and	CC
cord-259603-bh198xgl	200	16	Lys-90	lys-90	NN
cord-259603-bh198xgl	200	17	)	)	-RRB-
cord-259603-bh198xgl	200	18	in	in	IN
cord-259603-bh198xgl	200	19	the	the	DT
cord-259603-bh198xgl	200	20	β	β	NN
cord-259603-bh198xgl	200	21	-	-	HYPH
cord-259603-bh198xgl	200	22	barrel	barrel	NN
cord-259603-bh198xgl	200	23	domain	domain	NN
cord-259603-bh198xgl	200	24	of	of	IN
cord-259603-bh198xgl	200	25	IBV	IBV	NNP
cord-259603-bh198xgl	200	26	nsp9	nsp9	NNP
cord-259603-bh198xgl	200	27	also	also	RB
cord-259603-bh198xgl	200	28	significantly	significantly	RB
cord-259603-bh198xgl	200	29	reduced	reduce	VBD
cord-259603-bh198xgl	200	30	the	the	DT
cord-259603-bh198xgl	200	31	protein	protein	NN
cord-259603-bh198xgl	200	32	's	's	POS
cord-259603-bh198xgl	200	33	capability	capability	NN
cord-259603-bh198xgl	200	34	to	to	TO
cord-259603-bh198xgl	200	35	bind	bind	VB
cord-259603-bh198xgl	200	36	RNA	RNA	NNP
cord-259603-bh198xgl	200	37	in	in	IN
cord-259603-bh198xgl	200	38	vitro	vitro	FW
cord-259603-bh198xgl	200	39	,	,	,
cord-259603-bh198xgl	200	40	but	but	CC
cord-259603-bh198xgl	200	41	these	these	DT
cord-259603-bh198xgl	200	42	mutations	mutation	NNS
cord-259603-bh198xgl	200	43	only	only	RB
cord-259603-bh198xgl	200	44	modestly	modestly	RB
cord-259603-bh198xgl	200	45	affected	affect	VBD
cord-259603-bh198xgl	200	46	virus	virus	NN
cord-259603-bh198xgl	200	47	replication	replication	NN
cord-259603-bh198xgl	200	48	upon	upon	IN
cord-259603-bh198xgl	200	49	reverse	reverse	JJ
cord-259603-bh198xgl	200	50	engineering	engineering	NN
cord-259603-bh198xgl	201	1	(	(	-LRB-
cord-259603-bh198xgl	201	2	Chen	Chen	NNP
cord-259603-bh198xgl	201	3	et	et	NNP
cord-259603-bh198xgl	201	4	al	al	NNP
cord-259603-bh198xgl	201	5	.	.	NNP
cord-259603-bh198xgl	201	6	,	,	,
cord-259603-bh198xgl	201	7	2009a	2009a	CD
cord-259603-bh198xgl	201	8	)	)	-RRB-
cord-259603-bh198xgl	201	9	.	.	.
cord-259603-bh198xgl	202	1	It	-PRON-	PRP
cord-259603-bh198xgl	202	2	remains	remain	VBZ
cord-259603-bh198xgl	202	3	to	to	TO
cord-259603-bh198xgl	202	4	be	be	VB
cord-259603-bh198xgl	202	5	studied	study	VBN
cord-259603-bh198xgl	202	6	how	how	WRB
cord-259603-bh198xgl	202	7	nsp9	nsp9	DT
cord-259603-bh198xgl	202	8	dimerization	dimerization	NN
cord-259603-bh198xgl	202	9	and	and	CC
cord-259603-bh198xgl	202	10	mutagenesis	mutagenesis	NN
cord-259603-bh198xgl	202	11	may	may	MD
cord-259603-bh198xgl	202	12	affect	affect	VB
cord-259603-bh198xgl	202	13	interactions	interaction	NNS
cord-259603-bh198xgl	202	14	with	with	IN
cord-259603-bh198xgl	202	15	other	other	JJ
cord-259603-bh198xgl	202	16	replicase	replicase	NN
cord-259603-bh198xgl	202	17	subunits	subunit	NNS
cord-259603-bh198xgl	202	18	,	,	,
cord-259603-bh198xgl	202	19	like	like	IN
cord-259603-bh198xgl	202	20	nsp8	nsp8	NN
cord-259603-bh198xgl	202	21	and	and	CC
cord-259603-bh198xgl	202	22	nsp12-RdRp	nsp12-rdrp	NN
cord-259603-bh198xgl	202	23	.	.	.
cord-259603-bh198xgl	203	1	These	these	DT
cord-259603-bh198xgl	203	2	proteins	protein	NNS
cord-259603-bh198xgl	203	3	were	be	VBD
cord-259603-bh198xgl	203	4	identified	identify	VBN
cord-259603-bh198xgl	203	5	as	as	IN
cord-259603-bh198xgl	203	6	nsp9	nsp9	DT
cord-259603-bh198xgl	203	7	interaction	interaction	NN
cord-259603-bh198xgl	203	8	partners	partner	NNS
cord-259603-bh198xgl	203	9	using	use	VBG
cord-259603-bh198xgl	203	10	different	different	JJ
cord-259603-bh198xgl	203	11	technical	technical	JJ
cord-259603-bh198xgl	203	12	approaches	approach	NNS
cord-259603-bh198xgl	203	13	(	(	-LRB-
cord-259603-bh198xgl	203	14	Brockway	Brockway	NNP
cord-259603-bh198xgl	203	15	et	et	NNP
cord-259603-bh198xgl	203	16	al	al	NNP
cord-259603-bh198xgl	203	17	.	.	NNP
cord-259603-bh198xgl	203	18	,	,	,
cord-259603-bh198xgl	203	19	2003	2003	CD
cord-259603-bh198xgl	203	20	;	;	:
cord-259603-bh198xgl	203	21	Sutton	Sutton	NNP
cord-259603-bh198xgl	203	22	et	et	NNP
cord-259603-bh198xgl	203	23	al	al	NNP
cord-259603-bh198xgl	203	24	.	.	NNP
cord-259603-bh198xgl	203	25	,	,	,
cord-259603-bh198xgl	203	26	2004	2004	CD
cord-259603-bh198xgl	203	27	;	;	:
cord-259603-bh198xgl	203	28	von	von	NNP
cord-259603-bh198xgl	203	29	Brunn	Brunn	NNP
cord-259603-bh198xgl	203	30	et	et	NNP
cord-259603-bh198xgl	203	31	al	al	NNP
cord-259603-bh198xgl	203	32	.	.	NNP
cord-259603-bh198xgl	203	33	,	,	,
cord-259603-bh198xgl	203	34	2007	2007	CD
cord-259603-bh198xgl	203	35	)	)	-RRB-
cord-259603-bh198xgl	203	36	and	and	CC
cord-259603-bh198xgl	203	37	colocalize	colocalize	NN
cord-259603-bh198xgl	203	38	with	with	IN
cord-259603-bh198xgl	203	39	nsp9	nsp9	NN
cord-259603-bh198xgl	203	40	on	on	IN
cord-259603-bh198xgl	203	41	the	the	DT
cord-259603-bh198xgl	203	42	membranous	membranous	JJ
cord-259603-bh198xgl	203	43	replication	replication	NN
cord-259603-bh198xgl	203	44	organelles	organelle	NNS
cord-259603-bh198xgl	203	45	(	(	-LRB-
cord-259603-bh198xgl	203	46	Bost	Bost	NNP
cord-259603-bh198xgl	203	47	et	et	NNP
cord-259603-bh198xgl	203	48	al	al	NNP
cord-259603-bh198xgl	203	49	.	.	NNP
cord-259603-bh198xgl	203	50	,	,	,
cord-259603-bh198xgl	203	51	2000	2000	CD
cord-259603-bh198xgl	203	52	)	)	-RRB-
cord-259603-bh198xgl	203	53	.	.	.
cord-259603-bh198xgl	204	1	At	at	IN
cord-259603-bh198xgl	204	2	present	present	NN
cord-259603-bh198xgl	204	3	,	,	,
cord-259603-bh198xgl	204	4	the	the	DT
cord-259603-bh198xgl	204	5	available	available	JJ
cord-259603-bh198xgl	204	6	data	datum	NNS
cord-259603-bh198xgl	204	7	suggest	suggest	VBP
cord-259603-bh198xgl	204	8	that	that	IN
cord-259603-bh198xgl	204	9	,	,	,
cord-259603-bh198xgl	204	10	for	for	IN
cord-259603-bh198xgl	204	11	efficient	efficient	JJ
cord-259603-bh198xgl	204	12	CoV	cov	NN
cord-259603-bh198xgl	204	13	replication	replication	NN
cord-259603-bh198xgl	204	14	,	,	,
cord-259603-bh198xgl	204	15	nsp9	nsp9	DT
cord-259603-bh198xgl	204	16	homodimerization	homodimerization	NN
cord-259603-bh198xgl	204	17	is	be	VBZ
cord-259603-bh198xgl	204	18	a	a	DT
cord-259603-bh198xgl	204	19	more	more	RBR
cord-259603-bh198xgl	204	20	critical	critical	JJ
cord-259603-bh198xgl	204	21	feature	feature	NN
cord-259603-bh198xgl	204	22	than	than	IN
cord-259603-bh198xgl	204	23	the	the	DT
cord-259603-bh198xgl	204	24	protein	protein	NN
cord-259603-bh198xgl	204	25	's	's	POS
cord-259603-bh198xgl	204	26	affinity	affinity	NN
cord-259603-bh198xgl	204	27	for	for	IN
cord-259603-bh198xgl	204	28	RNA	RNA	NNP
cord-259603-bh198xgl	204	29	per	per	FW
cord-259603-bh198xgl	204	30	se	se	FW
cord-259603-bh198xgl	204	31	.	.	.
cord-259603-bh198xgl	205	1	Alternatively	alternatively	RB
cord-259603-bh198xgl	205	2	,	,	,
cord-259603-bh198xgl	205	3	the	the	DT
cord-259603-bh198xgl	205	4	correct	correct	JJ
cord-259603-bh198xgl	205	5	positioning	positioning	NN
cord-259603-bh198xgl	205	6	of	of	IN
cord-259603-bh198xgl	205	7	RNA	RNA	NNP
cord-259603-bh198xgl	205	8	on	on	IN
cord-259603-bh198xgl	205	9	larger	large	JJR
cord-259603-bh198xgl	205	10	protein	protein	NN
cord-259603-bh198xgl	205	11	complexes	complex	NNS
cord-259603-bh198xgl	205	12	consisting	consist	VBG
cord-259603-bh198xgl	205	13	of	of	IN
cord-259603-bh198xgl	205	14	(	(	-LRB-
cord-259603-bh198xgl	205	15	or	or	CC
cord-259603-bh198xgl	205	16	containing	contain	VBG
cord-259603-bh198xgl	205	17	)	)	-RRB-
cord-259603-bh198xgl	206	1	nsp9	nsp9	NNP
cord-259603-bh198xgl	206	2	may	may	MD
cord-259603-bh198xgl	206	3	be	be	VB
cord-259603-bh198xgl	206	4	important	important	JJ
cord-259603-bh198xgl	206	5	for	for	IN
cord-259603-bh198xgl	206	6	the	the	DT
cord-259603-bh198xgl	206	7	protein	protein	NN
cord-259603-bh198xgl	206	8	's	's	POS
cord-259603-bh198xgl	206	9	correct	correct	JJ
cord-259603-bh198xgl	206	10	functioning	functioning	NN
cord-259603-bh198xgl	206	11	in	in	IN
cord-259603-bh198xgl	206	12	viral	viral	JJ
cord-259603-bh198xgl	206	13	RNA	RNA	NNP
cord-259603-bh198xgl	206	14	synthesis	synthesis	NN
cord-259603-bh198xgl	207	1	(	(	-LRB-
cord-259603-bh198xgl	207	2	Miknis	Miknis	NNP
cord-259603-bh198xgl	207	3	et	et	NNP
cord-259603-bh198xgl	207	4	al	al	NNP
cord-259603-bh198xgl	207	5	.	.	NNP
cord-259603-bh198xgl	207	6	,	,	,
cord-259603-bh198xgl	207	7	2009	2009	CD
cord-259603-bh198xgl	207	8	)	)	-RRB-
cord-259603-bh198xgl	207	9	.	.	.
cord-259603-bh198xgl	208	1	Currently	currently	RB
cord-259603-bh198xgl	208	2	,	,	,
cord-259603-bh198xgl	208	3	the	the	DT
cord-259603-bh198xgl	208	4	fact	fact	NN
cord-259603-bh198xgl	208	5	that	that	IN
cord-259603-bh198xgl	208	6	suppressor	suppressor	NN
cord-259603-bh198xgl	208	7	mutations	mutation	NNS
cord-259603-bh198xgl	208	8	arose	arise	VBD
cord-259603-bh198xgl	208	9	in	in	IN
cord-259603-bh198xgl	208	10	MHV	MHV	NNP
cord-259603-bh198xgl	208	11	nsp9	nsp9	NNP
cord-259603-bh198xgl	208	12	(	(	-LRB-
cord-259603-bh198xgl	208	13	and	and	CC
cord-259603-bh198xgl	208	14	nsp8	nsp8	JJ
cord-259603-bh198xgl	208	15	)	)	-RRB-
cord-259603-bh198xgl	208	16	after	after	IN
cord-259603-bh198xgl	208	17	mutagenesis	mutagenesis	NN
cord-259603-bh198xgl	208	18	of	of	IN
cord-259603-bh198xgl	208	19	3	3	CD
cord-259603-bh198xgl	208	20	0	0	CD
cord-259603-bh198xgl	208	21	-proximal	-proximal	ADD
cord-259603-bh198xgl	209	1	MHV	mhv	NN
cord-259603-bh198xgl	209	2	replication	replication	NN
cord-259603-bh198xgl	209	3	signals	signal	NNS
cord-259603-bh198xgl	209	4	(	(	-LRB-
cord-259603-bh198xgl	209	5	see	see	VB
cord-259603-bh198xgl	209	6	earlier	early	RBR
cord-259603-bh198xgl	209	7	)	)	-RRB-
cord-259603-bh198xgl	209	8	is	be	VBZ
cord-259603-bh198xgl	209	9	the	the	DT
cord-259603-bh198xgl	209	10	most	most	RBS
cord-259603-bh198xgl	209	11	compelling	compelling	JJ
cord-259603-bh198xgl	209	12	evidence	evidence	NN
cord-259603-bh198xgl	209	13	for	for	IN
cord-259603-bh198xgl	209	14	the	the	DT
cord-259603-bh198xgl	209	15	involvement	involvement	NN
cord-259603-bh198xgl	209	16	of	of	IN
cord-259603-bh198xgl	209	17	nsp9-RNA	nsp9-rna	CD
cord-259603-bh198xgl	209	18	interactions	interaction	NNS
cord-259603-bh198xgl	209	19	in	in	IN
cord-259603-bh198xgl	209	20	a	a	DT
cord-259603-bh198xgl	209	21	critical	critical	JJ
cord-259603-bh198xgl	209	22	step	step	NN
cord-259603-bh198xgl	209	23	of	of	IN
cord-259603-bh198xgl	209	24	CoV	cov	NN
cord-259603-bh198xgl	209	25	replication	replication	NN
cord-259603-bh198xgl	209	26	.	.	.
cord-259603-bh198xgl	210	1	The	the	DT
cord-259603-bh198xgl	210	2	protein	protein	NN
cord-259603-bh198xgl	210	3	may	may	MD
cord-259603-bh198xgl	210	4	be	be	VB
cord-259603-bh198xgl	210	5	part	part	NN
cord-259603-bh198xgl	210	6	of	of	IN
cord-259603-bh198xgl	210	7	a	a	DT
cord-259603-bh198xgl	210	8	molecular	molecular	JJ
cord-259603-bh198xgl	210	9	switch	switch	NN
cord-259603-bh198xgl	210	10	(	(	-LRB-
cord-259603-bh198xgl	210	11	Z€	Z€	NNP
cord-259603-bh198xgl	210	12	ust	ust	NNP
cord-259603-bh198xgl	210	13	et	et	NNP
cord-259603-bh198xgl	210	14	al	al	NNP
cord-259603-bh198xgl	210	15	.	.	NNP
cord-259603-bh198xgl	210	16	,	,	,
cord-259603-bh198xgl	210	17	2008	2008	CD
cord-259603-bh198xgl	210	18	)	)	-RRB-
cord-259603-bh198xgl	211	1	and/or	and/or	CC
cord-259603-bh198xgl	211	2	possess	possess	VB
cord-259603-bh198xgl	211	3	features	feature	NNS
cord-259603-bh198xgl	211	4	that	that	WDT
cord-259603-bh198xgl	211	5	are	be	VBP
cord-259603-bh198xgl	211	6	relevant	relevant	JJ
cord-259603-bh198xgl	211	7	to	to	IN
cord-259603-bh198xgl	211	8	viral	viral	JJ
cord-259603-bh198xgl	211	9	pathogenesis	pathogenesis	NN
cord-259603-bh198xgl	211	10	,	,	,
cord-259603-bh198xgl	211	11	as	as	IN
cord-259603-bh198xgl	211	12	mutations	mutation	NNS
cord-259603-bh198xgl	211	13	in	in	IN
cord-259603-bh198xgl	211	14	nsp9	nsp9	DT
cord-259603-bh198xgl	211	15	were	be	VBD
cord-259603-bh198xgl	211	16	found	find	VBN
cord-259603-bh198xgl	211	17	to	to	TO
cord-259603-bh198xgl	211	18	contribute	contribute	VB
cord-259603-bh198xgl	211	19	to	to	IN
cord-259603-bh198xgl	211	20	increased	increase	VBN
cord-259603-bh198xgl	211	21	SARS	SARS	NNP
cord-259603-bh198xgl	211	22	-	-	HYPH
cord-259603-bh198xgl	211	23	CoV	CoV	NNP
cord-259603-bh198xgl	211	24	pathogenesis	pathogenesis	NN
cord-259603-bh198xgl	211	25	in	in	IN
cord-259603-bh198xgl	211	26	an	an	DT
cord-259603-bh198xgl	211	27	animal	animal	NN
cord-259603-bh198xgl	211	28	model	model	NN
cord-259603-bh198xgl	211	29	employing	employ	VBG
cord-259603-bh198xgl	211	30	young	young	JJ
cord-259603-bh198xgl	211	31	mice	mouse	NNS
cord-259603-bh198xgl	211	32	infected	infect	VBN
cord-259603-bh198xgl	211	33	with	with	IN
cord-259603-bh198xgl	211	34	a	a	DT
cord-259603-bh198xgl	211	35	mouse	mouse	NN
cord-259603-bh198xgl	211	36	-	-	HYPH
cord-259603-bh198xgl	211	37	adapted	adapt	VBN
cord-259603-bh198xgl	211	38	virus	virus	NN
cord-259603-bh198xgl	211	39	strain	strain	NN
cord-259603-bh198xgl	211	40	(	(	-LRB-
cord-259603-bh198xgl	211	41	MA-15	ma-15	NN
cord-259603-bh198xgl	211	42	)	)	-RRB-
cord-259603-bh198xgl	212	1	(	(	-LRB-
cord-259603-bh198xgl	212	2	Frieman	Frieman	NNP
cord-259603-bh198xgl	212	3	et	et	FW
cord-259603-bh198xgl	212	4	al	al	NNP
cord-259603-bh198xgl	212	5	.	.	NNP
cord-259603-bh198xgl	212	6	,	,	,
cord-259603-bh198xgl	212	7	2012	2012	CD
cord-259603-bh198xgl	212	8	)	)	-RRB-
cord-259603-bh198xgl	212	9	.	.	.
cord-259603-bh198xgl	213	1	The	the	DT
cord-259603-bh198xgl	213	2	small	small	JJ
cord-259603-bh198xgl	213	3	nsp10	nsp10	NNS
cord-259603-bh198xgl	213	4	subunit	subunit	NN
cord-259603-bh198xgl	213	5	(	(	-LRB-
cord-259603-bh198xgl	213	6	139	139	CD
cord-259603-bh198xgl	213	7	residues	residue	NNS
cord-259603-bh198xgl	213	8	in	in	IN
cord-259603-bh198xgl	213	9	the	the	DT
cord-259603-bh198xgl	213	10	case	case	NN
cord-259603-bh198xgl	213	11	of	of	IN
cord-259603-bh198xgl	213	12	SARS	SARS	NNP
cord-259603-bh198xgl	213	13	-	-	HYPH
cord-259603-bh198xgl	213	14	CoV	CoV	NNP
cord-259603-bh198xgl	213	15	)	)	-RRB-
cord-259603-bh198xgl	213	16	is	be	VBZ
cord-259603-bh198xgl	213	17	among	among	IN
cord-259603-bh198xgl	213	18	the	the	DT
cord-259603-bh198xgl	213	19	more	more	RBR
cord-259603-bh198xgl	213	20	conserved	conserved	JJ
cord-259603-bh198xgl	213	21	CoV	cov	NN
cord-259603-bh198xgl	213	22	proteins	protein	NNS
cord-259603-bh198xgl	213	23	and	and	CC
cord-259603-bh198xgl	213	24	is	be	VBZ
cord-259603-bh198xgl	213	25	thought	think	VBN
cord-259603-bh198xgl	213	26	to	to	TO
cord-259603-bh198xgl	213	27	serve	serve	VB
cord-259603-bh198xgl	213	28	as	as	IN
cord-259603-bh198xgl	213	29	an	an	DT
cord-259603-bh198xgl	213	30	important	important	JJ
cord-259603-bh198xgl	213	31	multifunctional	multifunctional	JJ
cord-259603-bh198xgl	213	32	cofactor	cofactor	NN
cord-259603-bh198xgl	213	33	in	in	IN
cord-259603-bh198xgl	213	34	replication	replication	NN
cord-259603-bh198xgl	213	35	.	.	.
cord-259603-bh198xgl	214	1	Using	use	VBG
cord-259603-bh198xgl	214	2	yeast	yeast	NN
cord-259603-bh198xgl	214	3	two	two	CD
cord-259603-bh198xgl	214	4	-	-	HYPH
cord-259603-bh198xgl	214	5	hybrid	hybrid	NN
cord-259603-bh198xgl	214	6	assays	assay	NNS
cord-259603-bh198xgl	214	7	,	,	,
cord-259603-bh198xgl	214	8	nsp10	nsp10	NNP
cord-259603-bh198xgl	214	9	was	be	VBD
cord-259603-bh198xgl	214	10	shown	show	VBN
cord-259603-bh198xgl	214	11	to	to	TO
cord-259603-bh198xgl	214	12	interact	interact	VB
cord-259603-bh198xgl	214	13	with	with	IN
cord-259603-bh198xgl	214	14	itself	-PRON-	PRP
cord-259603-bh198xgl	214	15	,	,	,
cord-259603-bh198xgl	214	16	as	as	RB
cord-259603-bh198xgl	214	17	well	well	RB
cord-259603-bh198xgl	214	18	as	as	IN
cord-259603-bh198xgl	214	19	with	with	IN
cord-259603-bh198xgl	214	20	nsp1	nsp1	NNS
cord-259603-bh198xgl	214	21	,	,	,
cord-259603-bh198xgl	214	22	nsp7	nsp7	UH
cord-259603-bh198xgl	214	23	,	,	,
cord-259603-bh198xgl	214	24	nsp14	nsp14	NNP
cord-259603-bh198xgl	214	25	,	,	,
cord-259603-bh198xgl	214	26	and	and	CC
cord-259603-bh198xgl	214	27	nsp16	nsp16	NNS
cord-259603-bh198xgl	214	28	.	.	.
cord-259603-bh198xgl	215	1	These	these	DT
cord-259603-bh198xgl	215	2	interactions	interaction	NNS
cord-259603-bh198xgl	215	3	were	be	VBD
cord-259603-bh198xgl	215	4	confirmed	confirm	VBN
cord-259603-bh198xgl	215	5	by	by	IN
cord-259603-bh198xgl	215	6	coimmunoprecipitation	coimmunoprecipitation	NN
cord-259603-bh198xgl	215	7	and/or	and/or	CC
cord-259603-bh198xgl	215	8	GST	GST	NNP
cord-259603-bh198xgl	215	9	pull	pull	VB
cord-259603-bh198xgl	215	10	-	-	HYPH
cord-259603-bh198xgl	215	11	down	down	RP
cord-259603-bh198xgl	215	12	assays	assay	NNS
cord-259603-bh198xgl	215	13	(	(	-LRB-
cord-259603-bh198xgl	215	14	Brockway	Brockway	NNP
cord-259603-bh198xgl	215	15	et	et	NNP
cord-259603-bh198xgl	215	16	al	al	NNP
cord-259603-bh198xgl	215	17	.	.	NNP
cord-259603-bh198xgl	215	18	,	,	,
cord-259603-bh198xgl	215	19	2004	2004	CD
cord-259603-bh198xgl	215	20	;	;	:
cord-259603-bh198xgl	216	1	Imbert	Imbert	NNP
cord-259603-bh198xgl	216	2	et	et	NNP
cord-259603-bh198xgl	216	3	al	al	NNP
cord-259603-bh198xgl	216	4	.	.	NNP
cord-259603-bh198xgl	216	5	,	,	,
cord-259603-bh198xgl	216	6	2008	2008	CD
cord-259603-bh198xgl	216	7	;	;	.
cord-259603-bh198xgl	217	1	Pan	Pan	NNP
cord-259603-bh198xgl	217	2	et	et	NNP
cord-259603-bh198xgl	217	3	al	al	NNP
cord-259603-bh198xgl	217	4	.	.	.
cord-259603-bh198xgl	218	1	,	,	,
cord-259603-bh198xgl	218	2	2008	2008	CD
cord-259603-bh198xgl	218	3	;	;	:
cord-259603-bh198xgl	218	4	von	von	NNP
cord-259603-bh198xgl	218	5	Brunn	Brunn	NNP
cord-259603-bh198xgl	218	6	et	et	NNP
cord-259603-bh198xgl	218	7	al	al	NNP
cord-259603-bh198xgl	218	8	.	.	NNP
cord-259603-bh198xgl	218	9	,	,	,
cord-259603-bh198xgl	218	10	2007	2007	CD
cord-259603-bh198xgl	218	11	)	)	-RRB-
cord-259603-bh198xgl	218	12	.	.	.
cord-259603-bh198xgl	219	1	The	the	DT
cord-259603-bh198xgl	219	2	important	important	JJ
cord-259603-bh198xgl	219	3	role	role	NN
cord-259603-bh198xgl	219	4	of	of	IN
cord-259603-bh198xgl	219	5	nsp10	nsp10	PRP
cord-259603-bh198xgl	219	6	in	in	IN
cord-259603-bh198xgl	219	7	replication	replication	NN
cord-259603-bh198xgl	219	8	was	be	VBD
cord-259603-bh198xgl	219	9	first	first	RB
cord-259603-bh198xgl	219	10	inferred	infer	VBN
cord-259603-bh198xgl	219	11	from	from	IN
cord-259603-bh198xgl	219	12	the	the	DT
cord-259603-bh198xgl	219	13	phenotype	phenotype	NN
cord-259603-bh198xgl	219	14	of	of	IN
cord-259603-bh198xgl	219	15	temperature	temperature	NN
cord-259603-bh198xgl	219	16	-	-	HYPH
cord-259603-bh198xgl	219	17	sensitive	sensitive	JJ
cord-259603-bh198xgl	219	18	mutants	mutant	NNS
cord-259603-bh198xgl	219	19	of	of	IN
cord-259603-bh198xgl	219	20	MHV	MHV	NNP
cord-259603-bh198xgl	219	21	in	in	IN
cord-259603-bh198xgl	219	22	which	which	WDT
cord-259603-bh198xgl	219	23	an	an	DT
cord-259603-bh198xgl	219	24	nsp10	nsp10	JJ
cord-259603-bh198xgl	219	25	mutation	mutation	NN
cord-259603-bh198xgl	219	26	was	be	VBD
cord-259603-bh198xgl	219	27	responsible	responsible	JJ
cord-259603-bh198xgl	219	28	for	for	IN
cord-259603-bh198xgl	219	29	a	a	DT
cord-259603-bh198xgl	219	30	defect	defect	NN
cord-259603-bh198xgl	219	31	in	in	IN
cord-259603-bh198xgl	219	32	minus	minus	JJ
cord-259603-bh198xgl	219	33	-	-	HYPH
cord-259603-bh198xgl	219	34	strand	strand	NN
cord-259603-bh198xgl	219	35	RNA	RNA	NNP
cord-259603-bh198xgl	219	36	synthesis	synthesis	NN
cord-259603-bh198xgl	220	1	(	(	-LRB-
cord-259603-bh198xgl	220	2	Sawicki	Sawicki	NNP
cord-259603-bh198xgl	220	3	et	et	NNP
cord-259603-bh198xgl	220	4	al	al	NNP
cord-259603-bh198xgl	220	5	.	.	NNP
cord-259603-bh198xgl	220	6	,	,	,
cord-259603-bh198xgl	220	7	2005	2005	CD
cord-259603-bh198xgl	220	8	)	)	-RRB-
cord-259603-bh198xgl	220	9	.	.	.
cord-259603-bh198xgl	221	1	In	in	IN
cord-259603-bh198xgl	221	2	addition	addition	NN
cord-259603-bh198xgl	221	3	,	,	,
cord-259603-bh198xgl	221	4	the	the	DT
cord-259603-bh198xgl	221	5	protein	protein	NN
cord-259603-bh198xgl	221	6	was	be	VBD
cord-259603-bh198xgl	221	7	implicated	implicate	VBN
cord-259603-bh198xgl	221	8	in	in	IN
cord-259603-bh198xgl	221	9	the	the	DT
cord-259603-bh198xgl	221	10	regulation	regulation	NN
cord-259603-bh198xgl	221	11	of	of	IN
cord-259603-bh198xgl	221	12	polyprotein	polyprotein	JJ
cord-259603-bh198xgl	221	13	processing	processing	NN
cord-259603-bh198xgl	221	14	since	since	IN
cord-259603-bh198xgl	221	15	an	an	DT
cord-259603-bh198xgl	221	16	engineered	engineer	VBN
cord-259603-bh198xgl	221	17	MHV	MHV	NNP
cord-259603-bh198xgl	221	18	nsp10	nsp10	RB
cord-259603-bh198xgl	221	19	double	double	JJ
cord-259603-bh198xgl	221	20	mutant	mutant	NN
cord-259603-bh198xgl	221	21	(	(	-LRB-
cord-259603-bh198xgl	221	22	Asp-47	asp-47	NN
cord-259603-bh198xgl	221	23	and	and	CC
cord-259603-bh198xgl	221	24	His-48	His-48	NNP
cord-259603-bh198xgl	221	25	to	to	IN
cord-259603-bh198xgl	221	26	Ala	Ala	NNP
cord-259603-bh198xgl	221	27	)	)	-RRB-
cord-259603-bh198xgl	221	28	was	be	VBD
cord-259603-bh198xgl	221	29	partially	partially	RB
cord-259603-bh198xgl	221	30	impaired	impair	VBN
cord-259603-bh198xgl	221	31	in	in	IN
cord-259603-bh198xgl	221	32	the	the	DT
cord-259603-bh198xgl	221	33	processing	processing	NN
cord-259603-bh198xgl	221	34	of	of	IN
cord-259603-bh198xgl	221	35	the	the	DT
cord-259603-bh198xgl	221	36	nsp4-nsp11	nsp4-nsp11	JJ
cord-259603-bh198xgl	221	37	region	region	NN
cord-259603-bh198xgl	221	38	(	(	-LRB-
cord-259603-bh198xgl	221	39	Donaldson	Donaldson	NNP
cord-259603-bh198xgl	221	40	et	et	NNP
cord-259603-bh198xgl	221	41	al	al	NNP
cord-259603-bh198xgl	221	42	.	.	NNP
cord-259603-bh198xgl	221	43	,	,	,
cord-259603-bh198xgl	221	44	2007	2007	CD
cord-259603-bh198xgl	221	45	)	)	-RRB-
cord-259603-bh198xgl	221	46	.	.	.
cord-259603-bh198xgl	222	1	When	when	WRB
cord-259603-bh198xgl	222	2	nsp10	nsp10	NNP
cord-259603-bh198xgl	222	3	was	be	VBD
cord-259603-bh198xgl	222	4	characterized	characterize	VBN
cord-259603-bh198xgl	222	5	in	in	IN
cord-259603-bh198xgl	222	6	biochemical	biochemical	JJ
cord-259603-bh198xgl	222	7	and	and	CC
cord-259603-bh198xgl	222	8	structural	structural	JJ
cord-259603-bh198xgl	222	9	studies	study	NNS
cord-259603-bh198xgl	222	10	,	,	,
cord-259603-bh198xgl	222	11	the	the	DT
cord-259603-bh198xgl	222	12	protein	protein	NN
cord-259603-bh198xgl	222	13	was	be	VBD
cord-259603-bh198xgl	222	14	found	find	VBN
cord-259603-bh198xgl	222	15	to	to	TO
cord-259603-bh198xgl	222	16	bind	bind	VB
cord-259603-bh198xgl	222	17	two	two	CD
cord-259603-bh198xgl	222	18	Zn	Zn	NNP
cord-259603-bh198xgl	222	19	2	2	CD
cord-259603-bh198xgl	222	20	+	+	SYM
cord-259603-bh198xgl	222	21	ions	ion	NNS
cord-259603-bh198xgl	222	22	with	with	IN
cord-259603-bh198xgl	222	23	high	high	JJ
cord-259603-bh198xgl	222	24	affinity	affinity	NN
cord-259603-bh198xgl	222	25	,	,	,
cord-259603-bh198xgl	222	26	suggesting	suggest	VBG
cord-259603-bh198xgl	222	27	the	the	DT
cord-259603-bh198xgl	222	28	presence	presence	NN
cord-259603-bh198xgl	222	29	of	of	IN
cord-259603-bh198xgl	222	30	two	two	CD
cord-259603-bh198xgl	222	31	zinc	zinc	NN
cord-259603-bh198xgl	222	32	-	-	HYPH
cord-259603-bh198xgl	222	33	finger	finger	NN
cord-259603-bh198xgl	222	34	motifs	motif	NNS
cord-259603-bh198xgl	222	35	(	(	-LRB-
cord-259603-bh198xgl	222	36	Matthes	Matthes	NNP
cord-259603-bh198xgl	222	37	et	et	NNP
cord-259603-bh198xgl	222	38	al	al	NNP
cord-259603-bh198xgl	222	39	.	.	NNP
cord-259603-bh198xgl	222	40	,	,	,
cord-259603-bh198xgl	222	41	2006	2006	CD
cord-259603-bh198xgl	222	42	)	)	-RRB-
cord-259603-bh198xgl	222	43	.	.	.
cord-259603-bh198xgl	223	1	Additionally	additionally	RB
cord-259603-bh198xgl	223	2	,	,	,
cord-259603-bh198xgl	223	3	in	in	IN
cord-259603-bh198xgl	223	4	in	in	FW
cord-259603-bh198xgl	223	5	vitro	vitro	FW
cord-259603-bh198xgl	223	6	assays	assay	NNS
cord-259603-bh198xgl	223	7	,	,	,
cord-259603-bh198xgl	223	8	nsp10	nsp10	PRP
cord-259603-bh198xgl	223	9	displayed	display	VBD
cord-259603-bh198xgl	223	10	a	a	DT
cord-259603-bh198xgl	223	11	weak	weak	JJ
cord-259603-bh198xgl	223	12	affinity	affinity	NN
cord-259603-bh198xgl	223	13	for	for	IN
cord-259603-bh198xgl	223	14	single	single	JJ
cord-259603-bh198xgl	223	15	-	-	HYPH
cord-259603-bh198xgl	223	16	and	and	CC
cord-259603-bh198xgl	223	17	doublestranded	doublestrande	VBD
cord-259603-bh198xgl	223	18	RNA	RNA	NNP
cord-259603-bh198xgl	223	19	and	and	CC
cord-259603-bh198xgl	223	20	DNA	DNA	NNP
cord-259603-bh198xgl	223	21	,	,	,
cord-259603-bh198xgl	223	22	although	although	IN
cord-259603-bh198xgl	223	23	no	no	DT
cord-259603-bh198xgl	223	24	obvious	obvious	JJ
cord-259603-bh198xgl	223	25	sequence	sequence	NN
cord-259603-bh198xgl	223	26	specificity	specificity	NN
cord-259603-bh198xgl	223	27	could	could	MD
cord-259603-bh198xgl	223	28	be	be	VB
cord-259603-bh198xgl	223	29	established	establish	VBN
cord-259603-bh198xgl	223	30	,	,	,
cord-259603-bh198xgl	223	31	suggesting	suggest	VBG
cord-259603-bh198xgl	223	32	that	that	IN
cord-259603-bh198xgl	223	33	the	the	DT
cord-259603-bh198xgl	223	34	protein	protein	NN
cord-259603-bh198xgl	223	35	may	may	MD
cord-259603-bh198xgl	223	36	function	function	VB
cord-259603-bh198xgl	223	37	as	as	IN
cord-259603-bh198xgl	223	38	part	part	NN
cord-259603-bh198xgl	223	39	of	of	IN
cord-259603-bh198xgl	223	40	a	a	DT
cord-259603-bh198xgl	223	41	larger	large	JJR
cord-259603-bh198xgl	223	42	RNA	rna	NN
cord-259603-bh198xgl	223	43	-	-	HYPH
cord-259603-bh198xgl	223	44	binding	bind	VBG
cord-259603-bh198xgl	223	45	complex	complex	NN
cord-259603-bh198xgl	223	46	.	.	.
cord-259603-bh198xgl	224	1	Crystal	crystal	NN
cord-259603-bh198xgl	224	2	structures	structure	NNS
cord-259603-bh198xgl	224	3	of	of	IN
cord-259603-bh198xgl	224	4	monomeric	monomeric	JJ
cord-259603-bh198xgl	224	5	and	and	CC
cord-259603-bh198xgl	224	6	dodecameric	dodecameric	JJ
cord-259603-bh198xgl	224	7	forms	form	NNS
cord-259603-bh198xgl	224	8	of	of	IN
cord-259603-bh198xgl	224	9	SARS	SARS	NNP
cord-259603-bh198xgl	224	10	-	-	HYPH
cord-259603-bh198xgl	224	11	CoV	CoV	NNP
cord-259603-bh198xgl	224	12	nsp10	nsp10	NNPS
cord-259603-bh198xgl	224	13	were	be	VBD
cord-259603-bh198xgl	224	14	solved	solve	VBN
cord-259603-bh198xgl	224	15	by	by	IN
cord-259603-bh198xgl	224	16	different	different	JJ
cord-259603-bh198xgl	224	17	laboratories	laboratory	NNS
cord-259603-bh198xgl	224	18	,	,	,
cord-259603-bh198xgl	224	19	but	but	CC
cord-259603-bh198xgl	224	20	obvious	obvious	JJ
cord-259603-bh198xgl	224	21	structural	structural	JJ
cord-259603-bh198xgl	224	22	rearrangements	rearrangement	NNS
cord-259603-bh198xgl	224	23	between	between	IN
cord-259603-bh198xgl	224	24	the	the	DT
cord-259603-bh198xgl	224	25	two	two	CD
cord-259603-bh198xgl	224	26	forms	form	NNS
cord-259603-bh198xgl	224	27	were	be	VBD
cord-259603-bh198xgl	224	28	not	not	RB
cord-259603-bh198xgl	224	29	detected	detect	VBN
cord-259603-bh198xgl	224	30	(	(	-LRB-
cord-259603-bh198xgl	224	31	Joseph	Joseph	NNP
cord-259603-bh198xgl	224	32	et	et	NNP
cord-259603-bh198xgl	224	33	al	al	NNP
cord-259603-bh198xgl	224	34	.	.	NNP
cord-259603-bh198xgl	224	35	,	,	,
cord-259603-bh198xgl	224	36	2007	2007	CD
cord-259603-bh198xgl	224	37	;	;	:
cord-259603-bh198xgl	224	38	Su	Su	NNP
cord-259603-bh198xgl	224	39	et	et	FW
cord-259603-bh198xgl	224	40	al	al	NNP
cord-259603-bh198xgl	224	41	.	.	NNP
cord-259603-bh198xgl	224	42	,	,	,
cord-259603-bh198xgl	224	43	2006	2006	CD
cord-259603-bh198xgl	224	44	)	)	-RRB-
cord-259603-bh198xgl	224	45	.	.	.
cord-259603-bh198xgl	225	1	The	the	DT
cord-259603-bh198xgl	225	2	structures	structure	NNS
cord-259603-bh198xgl	225	3	revealed	reveal	VBD
cord-259603-bh198xgl	225	4	a	a	DT
cord-259603-bh198xgl	225	5	new	new	JJ
cord-259603-bh198xgl	225	6	fold	fold	NN
cord-259603-bh198xgl	225	7	in	in	IN
cord-259603-bh198xgl	225	8	which	which	WDT
cord-259603-bh198xgl	225	9	the	the	DT
cord-259603-bh198xgl	225	10	Zn	Zn	NNP
cord-259603-bh198xgl	225	11	2	2	CD
cord-259603-bh198xgl	225	12	+	+	SYM
cord-259603-bh198xgl	225	13	ions	ion	NNS
cord-259603-bh198xgl	225	14	are	be	VBP
cord-259603-bh198xgl	225	15	coordinated	coordinate	VBN
cord-259603-bh198xgl	225	16	in	in	IN
cord-259603-bh198xgl	225	17	a	a	DT
cord-259603-bh198xgl	225	18	unique	unique	JJ
cord-259603-bh198xgl	225	19	conformation	conformation	NN
cord-259603-bh198xgl	225	20	and	and	CC
cord-259603-bh198xgl	225	21	in	in	IN
cord-259603-bh198xgl	225	22	which	which	WDT
cord-259603-bh198xgl	225	23	a	a	DT
cord-259603-bh198xgl	225	24	cluster	cluster	NN
cord-259603-bh198xgl	225	25	of	of	IN
cord-259603-bh198xgl	225	26	basic	basic	JJ
cord-259603-bh198xgl	225	27	residues	residue	NNS
cord-259603-bh198xgl	225	28	on	on	IN
cord-259603-bh198xgl	225	29	the	the	DT
cord-259603-bh198xgl	225	30	protein	protein	NN
cord-259603-bh198xgl	225	31	's	's	POS
cord-259603-bh198xgl	225	32	surface	surface	NN
cord-259603-bh198xgl	225	33	probably	probably	RB
cord-259603-bh198xgl	225	34	contributes	contribute	VBZ
cord-259603-bh198xgl	225	35	to	to	IN
cord-259603-bh198xgl	225	36	the	the	DT
cord-259603-bh198xgl	225	37	RNA	RNA	NNP
cord-259603-bh198xgl	225	38	-	-	HYPH
cord-259603-bh198xgl	225	39	binding	bind	VBG
cord-259603-bh198xgl	225	40	properties	property	NNS
cord-259603-bh198xgl	225	41	of	of	IN
cord-259603-bh198xgl	225	42	nsp10	nsp10	PRP
cord-259603-bh198xgl	225	43	.	.	.
cord-259603-bh198xgl	226	1	More	more	RBR
cord-259603-bh198xgl	226	2	recent	recent	JJ
cord-259603-bh198xgl	226	3	biochemical	biochemical	JJ
cord-259603-bh198xgl	226	4	studies	study	NNS
cord-259603-bh198xgl	226	5	revealed	reveal	VBD
cord-259603-bh198xgl	226	6	that	that	IN
cord-259603-bh198xgl	226	7	nsp10	nsp10	RB
cord-259603-bh198xgl	226	8	interacts	interact	VBZ
cord-259603-bh198xgl	226	9	with	with	IN
cord-259603-bh198xgl	226	10	nsp14	nsp14	NN
cord-259603-bh198xgl	226	11	and	and	CC
cord-259603-bh198xgl	226	12	nsp16	nsp16	NNS
cord-259603-bh198xgl	226	13	and	and	CC
cord-259603-bh198xgl	226	14	regulates	regulate	VBZ
cord-259603-bh198xgl	226	15	their	-PRON-	PRP$
cord-259603-bh198xgl	226	16	respective	respective	JJ
cord-259603-bh198xgl	226	17	ExoN	ExoN	NNP
cord-259603-bh198xgl	226	18	and	and	CC
cord-259603-bh198xgl	226	19	ribose-2	ribose-2	NNP
cord-259603-bh198xgl	226	20	0	0	CD
cord-259603-bh198xgl	227	1	-O	-O	:
cord-259603-bh198xgl	227	2	-	-	:
cord-259603-bh198xgl	227	3	MTase	MTase	NNP
cord-259603-bh198xgl	227	4	(	(	-LRB-
cord-259603-bh198xgl	227	5	2	2	CD
cord-259603-bh198xgl	227	6	0	0	CD
cord-259603-bh198xgl	227	7	-O	-o	CD
cord-259603-bh198xgl	227	8	-	-	HYPH
cord-259603-bh198xgl	227	9	MTase	MTase	NNP
cord-259603-bh198xgl	227	10	)	)	-RRB-
cord-259603-bh198xgl	227	11	activities	activity	NNS
cord-259603-bh198xgl	227	12	(	(	-LRB-
cord-259603-bh198xgl	227	13	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	227	14	et	et	NNP
cord-259603-bh198xgl	227	15	al	al	NNP
cord-259603-bh198xgl	227	16	.	.	NNP
cord-259603-bh198xgl	227	17	,	,	,
cord-259603-bh198xgl	227	18	2010	2010	CD
cord-259603-bh198xgl	228	1	(	(	-LRB-
cord-259603-bh198xgl	228	2	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	228	3	et	et	NNP
cord-259603-bh198xgl	228	4	al	al	NNP
cord-259603-bh198xgl	228	5	.	.	.
cord-259603-bh198xgl	229	1	,	,	,
cord-259603-bh198xgl	229	2	,	,	,
cord-259603-bh198xgl	229	3	2012	2012	CD
cord-259603-bh198xgl	229	4	.	.	.
cord-259603-bh198xgl	230	1	Both	both	CC
cord-259603-bh198xgl	230	2	these	these	DT
cord-259603-bh198xgl	230	3	cofactor	cofactor	NN
cord-259603-bh198xgl	230	4	functions	function	NNS
cord-259603-bh198xgl	230	5	will	will	MD
cord-259603-bh198xgl	230	6	be	be	VB
cord-259603-bh198xgl	230	7	discussed	discuss	VBN
cord-259603-bh198xgl	230	8	in	in	IN
cord-259603-bh198xgl	230	9	more	more	JJR
cord-259603-bh198xgl	230	10	detail	detail	NN
cord-259603-bh198xgl	230	11	later	later	RB
cord-259603-bh198xgl	230	12	,	,	,
cord-259603-bh198xgl	230	13	in	in	IN
cord-259603-bh198xgl	230	14	Section	section	NN
cord-259603-bh198xgl	230	15	5	5	CD
cord-259603-bh198xgl	230	16	.	.	.
cord-259603-bh198xgl	231	1	Although	although	IN
cord-259603-bh198xgl	231	2	a	a	DT
cord-259603-bh198xgl	231	3	virus	virus	NN
cord-259603-bh198xgl	231	4	-	-	HYPH
cord-259603-bh198xgl	231	5	encoded	encode	VBN
cord-259603-bh198xgl	231	6	RdRp	RdRp	NNP
cord-259603-bh198xgl	231	7	is	be	VBZ
cord-259603-bh198xgl	231	8	at	at	IN
cord-259603-bh198xgl	231	9	the	the	DT
cord-259603-bh198xgl	231	10	hub	hub	NN
cord-259603-bh198xgl	231	11	of	of	IN
cord-259603-bh198xgl	231	12	the	the	DT
cord-259603-bh198xgl	231	13	replication	replication	NN
cord-259603-bh198xgl	231	14	of	of	IN
cord-259603-bh198xgl	231	15	all	all	DT
cord-259603-bh198xgl	231	16	RNA	RNA	NNP
cord-259603-bh198xgl	231	17	viruses	virus	NNS
cord-259603-bh198xgl	231	18	,	,	,
cord-259603-bh198xgl	231	19	special	special	JJ
cord-259603-bh198xgl	231	20	properties	property	NNS
cord-259603-bh198xgl	231	21	have	have	VBP
cord-259603-bh198xgl	231	22	long	long	RB
cord-259603-bh198xgl	231	23	been	be	VBN
cord-259603-bh198xgl	231	24	attributed	attribute	VBN
cord-259603-bh198xgl	231	25	to	to	IN
cord-259603-bh198xgl	231	26	the	the	DT
cord-259603-bh198xgl	231	27	CoV	cov	NN
cord-259603-bh198xgl	231	28	RdRp	RdRp	NNP
cord-259603-bh198xgl	231	29	.	.	.
cord-259603-bh198xgl	232	1	These	these	DT
cord-259603-bh198xgl	232	2	ideas	idea	NNS
cord-259603-bh198xgl	232	3	find	find	VBP
cord-259603-bh198xgl	232	4	their	-PRON-	PRP$
cord-259603-bh198xgl	232	5	origin	origin	NN
cord-259603-bh198xgl	232	6	in	in	IN
cord-259603-bh198xgl	232	7	a	a	DT
cord-259603-bh198xgl	232	8	combination	combination	NN
cord-259603-bh198xgl	232	9	of	of	IN
cord-259603-bh198xgl	232	10	CoV	cov	NN
cord-259603-bh198xgl	232	11	features	feature	NNS
cord-259603-bh198xgl	232	12	,	,	,
cord-259603-bh198xgl	232	13	like	like	IN
cord-259603-bh198xgl	232	14	the	the	DT
cord-259603-bh198xgl	232	15	exceptionally	exceptionally	RB
cord-259603-bh198xgl	232	16	long	long	JJ
cord-259603-bh198xgl	232	17	RNA	RNA	NNP
cord-259603-bh198xgl	232	18	genome	genome	NN
cord-259603-bh198xgl	232	19	,	,	,
cord-259603-bh198xgl	232	20	the	the	DT
cord-259603-bh198xgl	232	21	complex	complex	JJ
cord-259603-bh198xgl	232	22	mechanism	mechanism	NN
cord-259603-bh198xgl	232	23	underlying	underlie	VBG
cord-259603-bh198xgl	232	24	subgenomic	subgenomic	NNP
cord-259603-bh198xgl	232	25	RNA	RNA	NNP
cord-259603-bh198xgl	232	26	synthesis	synthesis	NN
cord-259603-bh198xgl	233	1	Pasternak	Pasternak	NNP
cord-259603-bh198xgl	233	2	et	et	NNP
cord-259603-bh198xgl	233	3	al	al	NNP
cord-259603-bh198xgl	233	4	.	.	NNP
cord-259603-bh198xgl	233	5	,	,	,
cord-259603-bh198xgl	233	6	2006	2006	CD
cord-259603-bh198xgl	234	1	;	;	:
cord-259603-bh198xgl	234	2	Sawicki	Sawicki	NNP
cord-259603-bh198xgl	234	3	et	et	NNP
cord-259603-bh198xgl	234	4	al	al	NNP
cord-259603-bh198xgl	234	5	.	.	NNP
cord-259603-bh198xgl	234	6	,	,	,
cord-259603-bh198xgl	234	7	2007	2007	CD
cord-259603-bh198xgl	235	1	;	;	:
cord-259603-bh198xgl	235	2	Sola	Sola	NNP
cord-259603-bh198xgl	235	3	et	et	FW
cord-259603-bh198xgl	235	4	al	al	NNP
cord-259603-bh198xgl	235	5	.	.	NNP
cord-259603-bh198xgl	235	6	,	,	,
cord-259603-bh198xgl	235	7	2011	2011	CD
cord-259603-bh198xgl	235	8	)	)	-RRB-
cord-259603-bh198xgl	235	9	,	,	,
cord-259603-bh198xgl	235	10	the	the	DT
cord-259603-bh198xgl	235	11	reported	report	VBN
cord-259603-bh198xgl	235	12	high	high	JJ
cord-259603-bh198xgl	235	13	RNA	RNA	NNP
cord-259603-bh198xgl	235	14	recombination	recombination	NN
cord-259603-bh198xgl	235	15	frequency	frequency	NN
cord-259603-bh198xgl	235	16	(	(	-LRB-
cord-259603-bh198xgl	236	1	Graham	Graham	NNP
cord-259603-bh198xgl	236	2	and	and	CC
cord-259603-bh198xgl	236	3	Baric	Baric	NNP
cord-259603-bh198xgl	236	4	,	,	,
cord-259603-bh198xgl	236	5	2010	2010	CD
cord-259603-bh198xgl	236	6	;	;	:
cord-259603-bh198xgl	236	7	Lai	Lai	NNP
cord-259603-bh198xgl	236	8	and	and	CC
cord-259603-bh198xgl	236	9	Cavanagh	Cavanagh	NNP
cord-259603-bh198xgl	236	10	,	,	,
cord-259603-bh198xgl	236	11	1997	1997	CD
cord-259603-bh198xgl	236	12	)	)	-RRB-
cord-259603-bh198xgl	236	13	,	,	,
cord-259603-bh198xgl	236	14	and	and	CC
cord-259603-bh198xgl	236	15	the	the	DT
cord-259603-bh198xgl	236	16	size	size	NN
cord-259603-bh198xgl	236	17	and	and	CC
cord-259603-bh198xgl	236	18	positioning	positioning	NN
cord-259603-bh198xgl	236	19	of	of	IN
cord-259603-bh198xgl	236	20	the	the	DT
cord-259603-bh198xgl	236	21	RdRpcontaining	RdRpcontaining	NNP
cord-259603-bh198xgl	236	22	subunit	subunit	NN
cord-259603-bh198xgl	236	23	,	,	,
cord-259603-bh198xgl	236	24	nsp12	nsp12	CD
cord-259603-bh198xgl	236	25	,	,	,
cord-259603-bh198xgl	236	26	within	within	IN
cord-259603-bh198xgl	236	27	the	the	DT
cord-259603-bh198xgl	236	28	replicase	replicase	NNP
cord-259603-bh198xgl	236	29	polyprotein	polyprotein	NNP
cord-259603-bh198xgl	236	30	.	.	.
cord-259603-bh198xgl	237	1	It	-PRON-	PRP
cord-259603-bh198xgl	237	2	remains	remain	VBZ
cord-259603-bh198xgl	237	3	to	to	TO
cord-259603-bh198xgl	237	4	be	be	VB
cord-259603-bh198xgl	237	5	elucidated	elucidate	VBN
cord-259603-bh198xgl	237	6	to	to	IN
cord-259603-bh198xgl	237	7	which	which	WDT
cord-259603-bh198xgl	237	8	extent	extent	NN
cord-259603-bh198xgl	237	9	features	feature	VBZ
cord-259603-bh198xgl	237	10	like	like	IN
cord-259603-bh198xgl	237	11	polymerase	polymerase	NN
cord-259603-bh198xgl	237	12	processivity	processivity	NN
cord-259603-bh198xgl	237	13	,	,	,
cord-259603-bh198xgl	237	14	fidelity	fidelity	NN
cord-259603-bh198xgl	237	15	,	,	,
cord-259603-bh198xgl	237	16	and	and	CC
cord-259603-bh198xgl	237	17	template	template	NN
cord-259603-bh198xgl	237	18	switching	switching	NN
cord-259603-bh198xgl	237	19	(	(	-LRB-
cord-259603-bh198xgl	237	20	during	during	IN
cord-259603-bh198xgl	237	21	either	either	DT
cord-259603-bh198xgl	237	22	genomic	genomic	JJ
cord-259603-bh198xgl	237	23	recombination	recombination	NN
cord-259603-bh198xgl	237	24	or	or	CC
cord-259603-bh198xgl	237	25	subgenome	subgenome	NN
cord-259603-bh198xgl	237	26	-	-	HYPH
cord-259603-bh198xgl	237	27	length	length	NN
cord-259603-bh198xgl	237	28	negative	negative	JJ
cord-259603-bh198xgl	237	29	-	-	HYPH
cord-259603-bh198xgl	237	30	strand	strand	NN
cord-259603-bh198xgl	237	31	RNA	RNA	NNP
cord-259603-bh198xgl	237	32	synthesis	synthesis	NN
cord-259603-bh198xgl	237	33	)	)	-RRB-
cord-259603-bh198xgl	237	34	are	be	VBP
cord-259603-bh198xgl	237	35	determined	determine	VBN
cord-259603-bh198xgl	237	36	by	by	IN
cord-259603-bh198xgl	237	37	the	the	DT
cord-259603-bh198xgl	237	38	properties	property	NNS
cord-259603-bh198xgl	237	39	of	of	IN
cord-259603-bh198xgl	237	40	the	the	DT
cord-259603-bh198xgl	237	41	nsp12-RdRp	nsp12-RdRp	NNP
cord-259603-bh198xgl	237	42	subunit	subunit	NN
cord-259603-bh198xgl	237	43	itself	-PRON-	PRP
cord-259603-bh198xgl	237	44	or	or	CC
cord-259603-bh198xgl	237	45	by	by	IN
cord-259603-bh198xgl	237	46	some	some	DT
cord-259603-bh198xgl	237	47	of	of	IN
cord-259603-bh198xgl	237	48	its	-PRON-	PRP$
cord-259603-bh198xgl	237	49	protein	protein	NN
cord-259603-bh198xgl	237	50	cofactors	cofactor	NNS
cord-259603-bh198xgl	237	51	,	,	,
cord-259603-bh198xgl	237	52	such	such	JJ
cord-259603-bh198xgl	237	53	as	as	IN
cord-259603-bh198xgl	237	54	nsp7	nsp7	NNP
cord-259603-bh198xgl	237	55	and	and	CC
cord-259603-bh198xgl	237	56	nsp8	nsp8	NN
cord-259603-bh198xgl	237	57	(	(	-LRB-
cord-259603-bh198xgl	237	58	see	see	VB
cord-259603-bh198xgl	237	59	earlier	early	RBR
cord-259603-bh198xgl	237	60	)	)	-RRB-
cord-259603-bh198xgl	237	61	.	.	.
cord-259603-bh198xgl	238	1	In	in	IN
cord-259603-bh198xgl	238	2	fact	fact	NN
cord-259603-bh198xgl	238	3	,	,	,
cord-259603-bh198xgl	238	4	some	some	DT
cord-259603-bh198xgl	238	5	cofactors	cofactor	NNS
cord-259603-bh198xgl	238	6	have	have	VBP
cord-259603-bh198xgl	238	7	been	be	VBN
cord-259603-bh198xgl	238	8	studied	study	VBN
cord-259603-bh198xgl	238	9	more	more	RBR
cord-259603-bh198xgl	238	10	extensively	extensively	RB
cord-259603-bh198xgl	238	11	than	than	IN
cord-259603-bh198xgl	238	12	nsp12	nsp12	CD
cord-259603-bh198xgl	238	13	itself	-PRON-	PRP
cord-259603-bh198xgl	238	14	,	,	,
cord-259603-bh198xgl	238	15	and	and	CC
cord-259603-bh198xgl	238	16	the	the	DT
cord-259603-bh198xgl	238	17	same	same	JJ
cord-259603-bh198xgl	238	18	holds	hold	VBZ
cord-259603-bh198xgl	238	19	true	true	JJ
cord-259603-bh198xgl	238	20	for	for	IN
cord-259603-bh198xgl	238	21	some	some	DT
cord-259603-bh198xgl	238	22	of	of	IN
cord-259603-bh198xgl	238	23	the	the	DT
cord-259603-bh198xgl	238	24	specific	specific	JJ
cord-259603-bh198xgl	238	25	RNA	RNA	NNP
cord-259603-bh198xgl	238	26	signals	signal	NNS
cord-259603-bh198xgl	238	27	employed	employ	VBN
cord-259603-bh198xgl	238	28	by	by	IN
cord-259603-bh198xgl	238	29	the	the	DT
cord-259603-bh198xgl	238	30	RdRp	RdRp	NNP
cord-259603-bh198xgl	238	31	during	during	IN
cord-259603-bh198xgl	238	32	,	,	,
cord-259603-bh198xgl	238	33	e.g.	e.g.	RB
cord-259603-bh198xgl	238	34	,	,	,
cord-259603-bh198xgl	238	35	replication	replication	NN
cord-259603-bh198xgl	238	36	and	and	CC
cord-259603-bh198xgl	238	37	subgenomic	subgenomic	NNP
cord-259603-bh198xgl	238	38	mRNA	mRNA	NNP
cord-259603-bh198xgl	238	39	synthesis	synthesis	NN
cord-259603-bh198xgl	238	40	.	.	.
cord-259603-bh198xgl	239	1	Protein	protein	NN
cord-259603-bh198xgl	239	2	subunits	subunit	NNS
cord-259603-bh198xgl	239	3	of	of	IN
cord-259603-bh198xgl	239	4	the	the	DT
cord-259603-bh198xgl	239	5	larger	large	JJR
cord-259603-bh198xgl	239	6	RNAsynthesizing	rnasynthesizing	NN
cord-259603-bh198xgl	239	7	complex	complex	NN
cord-259603-bh198xgl	239	8	,	,	,
cord-259603-bh198xgl	239	9	like	like	IN
cord-259603-bh198xgl	239	10	nsp7-nsp8	nsp7-nsp8	NNP
cord-259603-bh198xgl	239	11	,	,	,
cord-259603-bh198xgl	239	12	the	the	DT
cord-259603-bh198xgl	239	13	nsp13-helicase	nsp13-helicase	NN
cord-259603-bh198xgl	239	14	,	,	,
cord-259603-bh198xgl	239	15	and	and	CC
cord-259603-bh198xgl	239	16	the	the	DT
cord-259603-bh198xgl	239	17	nsp14-ExoN	nsp14-ExoN	NNP
cord-259603-bh198xgl	239	18	,	,	,
cord-259603-bh198xgl	239	19	likely	likely	RB
cord-259603-bh198xgl	239	20	exert	exert	VB
cord-259603-bh198xgl	239	21	a	a	DT
cord-259603-bh198xgl	239	22	strong	strong	JJ
cord-259603-bh198xgl	239	23	influence	influence	NN
cord-259603-bh198xgl	239	24	on	on	IN
cord-259603-bh198xgl	239	25	RdRp	RdRp	NNP
cord-259603-bh198xgl	239	26	behavior	behavior	NN
cord-259603-bh198xgl	239	27	and	and	CC
cord-259603-bh198xgl	239	28	performance	performance	NN
cord-259603-bh198xgl	239	29	.	.	.
cord-259603-bh198xgl	240	1	On	on	IN
cord-259603-bh198xgl	240	2	the	the	DT
cord-259603-bh198xgl	240	3	other	other	JJ
cord-259603-bh198xgl	240	4	hand	hand	NN
cord-259603-bh198xgl	240	5	,	,	,
cord-259603-bh198xgl	240	6	a	a	DT
cord-259603-bh198xgl	240	7	recent	recent	JJ
cord-259603-bh198xgl	240	8	study	study	NN
cord-259603-bh198xgl	240	9	employing	employ	VBG
cord-259603-bh198xgl	240	10	homology	homology	NN
cord-259603-bh198xgl	240	11	modeling	model	VBG
cord-259603-bh198xgl	240	12	and	and	CC
cord-259603-bh198xgl	240	13	reverse	reverse	VB
cord-259603-bh198xgl	240	14	genetics	genetic	NNS
cord-259603-bh198xgl	240	15	of	of	IN
cord-259603-bh198xgl	240	16	the	the	DT
cord-259603-bh198xgl	240	17	MHV	MHV	NNP
cord-259603-bh198xgl	240	18	RdRp	RdRp	NNP
cord-259603-bh198xgl	240	19	domain	domain	NN
cord-259603-bh198xgl	240	20	described	describe	VBD
cord-259603-bh198xgl	240	21	the	the	DT
cord-259603-bh198xgl	240	22	first	first	JJ
cord-259603-bh198xgl	240	23	two	two	CD
cord-259603-bh198xgl	240	24	nsp12	nsp12	CD
cord-259603-bh198xgl	240	25	mutations	mutation	NNS
cord-259603-bh198xgl	240	26	that	that	WDT
cord-259603-bh198xgl	240	27	can	can	MD
cord-259603-bh198xgl	240	28	induce	induce	VB
cord-259603-bh198xgl	240	29	resistance	resistance	NN
cord-259603-bh198xgl	240	30	to	to	IN
cord-259603-bh198xgl	240	31	a	a	DT
cord-259603-bh198xgl	240	32	mutagen	mutagen	NN
cord-259603-bh198xgl	240	33	and	and	CC
cord-259603-bh198xgl	240	34	reduce	reduce	VB
cord-259603-bh198xgl	240	35	the	the	DT
cord-259603-bh198xgl	240	36	MHV	MHV	NNP
cord-259603-bh198xgl	240	37	RdRp	rdrp	NN
cord-259603-bh198xgl	240	38	error	error	NN
cord-259603-bh198xgl	240	39	rate	rate	NN
cord-259603-bh198xgl	240	40	during	during	IN
cord-259603-bh198xgl	240	41	virus	virus	NN
cord-259603-bh198xgl	240	42	passaging	passaging	NN
cord-259603-bh198xgl	240	43	(	(	-LRB-
cord-259603-bh198xgl	240	44	Sexton	Sexton	NNP
cord-259603-bh198xgl	240	45	et	et	FW
cord-259603-bh198xgl	240	46	al	al	NNP
cord-259603-bh198xgl	240	47	.	.	NNP
cord-259603-bh198xgl	240	48	,	,	,
cord-259603-bh198xgl	240	49	2016	2016	CD
cord-259603-bh198xgl	240	50	)	)	-RRB-
cord-259603-bh198xgl	240	51	.	.	.
cord-259603-bh198xgl	241	1	So	so	RB
cord-259603-bh198xgl	241	2	,	,	,
cord-259603-bh198xgl	241	3	not	not	RB
cord-259603-bh198xgl	241	4	unexpectedly	unexpectedly	RB
cord-259603-bh198xgl	241	5	,	,	,
cord-259603-bh198xgl	241	6	also	also	RB
cord-259603-bh198xgl	241	7	features	feature	VBZ
cord-259603-bh198xgl	241	8	within	within	IN
cord-259603-bh198xgl	241	9	nsp12	nsp12	CD
cord-259603-bh198xgl	241	10	itself	-PRON-	PRP
cord-259603-bh198xgl	241	11	contribute	contribute	VBP
cord-259603-bh198xgl	241	12	to	to	IN
cord-259603-bh198xgl	241	13	properties	property	NNS
cord-259603-bh198xgl	241	14	like	like	IN
cord-259603-bh198xgl	241	15	nucleotide	nucleotide	JJ
cord-259603-bh198xgl	241	16	selectivity	selectivity	NN
cord-259603-bh198xgl	241	17	and	and	CC
cord-259603-bh198xgl	241	18	fidelity	fidelity	NN
cord-259603-bh198xgl	241	19	regulation	regulation	NN
cord-259603-bh198xgl	241	20	.	.	.
cord-259603-bh198xgl	242	1	All	all	DT
cord-259603-bh198xgl	242	2	of	of	IN
cord-259603-bh198xgl	242	3	the	the	DT
cord-259603-bh198xgl	242	4	currently	currently	RB
cord-259603-bh198xgl	242	5	identified	identify	VBN
cord-259603-bh198xgl	242	6	nsp12	nsp12	CD
cord-259603-bh198xgl	242	7	cofactors	cofactor	NNS
cord-259603-bh198xgl	242	8	,	,	,
cord-259603-bh198xgl	242	9	and	and	CC
cord-259603-bh198xgl	242	10	most	most	JJS
cord-259603-bh198xgl	242	11	other	other	JJ
cord-259603-bh198xgl	242	12	CoV	cov	NN
cord-259603-bh198xgl	242	13	nsps	nsps	NNP
cord-259603-bh198xgl	242	14	,	,	,
cord-259603-bh198xgl	242	15	assemble	assemble	VB
cord-259603-bh198xgl	242	16	into	into	IN
cord-259603-bh198xgl	242	17	membrane	membrane	NN
cord-259603-bh198xgl	242	18	-	-	HYPH
cord-259603-bh198xgl	242	19	associated	associate	VBN
cord-259603-bh198xgl	242	20	enzyme	enzyme	NN
cord-259603-bh198xgl	242	21	complexes	complex	NNS
cord-259603-bh198xgl	242	22	(	(	-LRB-
cord-259603-bh198xgl	242	23	see	see	VB
cord-259603-bh198xgl	242	24	earlier	early	RBR
cord-259603-bh198xgl	242	25	)	)	-RRB-
cord-259603-bh198xgl	242	26	.	.	.
cord-259603-bh198xgl	243	1	The	the	DT
cord-259603-bh198xgl	243	2	large	large	JJ
cord-259603-bh198xgl	243	3	number	number	NN
cord-259603-bh198xgl	243	4	of	of	IN
cord-259603-bh198xgl	243	5	viral	viral	JJ
cord-259603-bh198xgl	243	6	subunits	subunit	NNS
cord-259603-bh198xgl	243	7	in	in	IN
cord-259603-bh198xgl	243	8	these	these	DT
cord-259603-bh198xgl	243	9	complexes	complex	NNS
cord-259603-bh198xgl	243	10	(	(	-LRB-
cord-259603-bh198xgl	243	11	Subissi	Subissi	NNP
cord-259603-bh198xgl	243	12	et	et	NNP
cord-259603-bh198xgl	243	13	al	al	NNP
cord-259603-bh198xgl	243	14	.	.	NNP
cord-259603-bh198xgl	243	15	,	,	,
cord-259603-bh198xgl	243	16	2014a	2014a	CD
cord-259603-bh198xgl	243	17	)	)	-RRB-
cord-259603-bh198xgl	243	18	,	,	,
cord-259603-bh198xgl	243	19	the	the	DT
cord-259603-bh198xgl	243	20	likely	likely	JJ
cord-259603-bh198xgl	243	21	requirement	requirement	NN
cord-259603-bh198xgl	243	22	for	for	IN
cord-259603-bh198xgl	243	23	host	host	NN
cord-259603-bh198xgl	243	24	factors	factor	NNS
cord-259603-bh198xgl	243	25	(	(	-LRB-
cord-259603-bh198xgl	243	26	van	van	NNP
cord-259603-bh198xgl	243	27	Hemert	Hemert	NNP
cord-259603-bh198xgl	243	28	et	et	NNP
cord-259603-bh198xgl	243	29	al	al	NNP
cord-259603-bh198xgl	243	30	.	.	NNP
cord-259603-bh198xgl	243	31	,	,	,
cord-259603-bh198xgl	243	32	2008	2008	CD
cord-259603-bh198xgl	243	33	)	)	-RRB-
cord-259603-bh198xgl	243	34	,	,	,
cord-259603-bh198xgl	243	35	and	and	CC
cord-259603-bh198xgl	243	36	the	the	DT
cord-259603-bh198xgl	243	37	concept	concept	NN
cord-259603-bh198xgl	243	38	of	of	IN
cord-259603-bh198xgl	243	39	RNA	RNA	NNP
cord-259603-bh198xgl	243	40	synthesis	synthesis	NN
cord-259603-bh198xgl	243	41	occurring	occur	VBG
cord-259603-bh198xgl	243	42	in	in	IN
cord-259603-bh198xgl	243	43	a	a	DT
cord-259603-bh198xgl	243	44	dedicated	dedicated	JJ
cord-259603-bh198xgl	243	45	microenvironment	microenvironment	NN
cord-259603-bh198xgl	243	46	in	in	IN
cord-259603-bh198xgl	243	47	the	the	DT
cord-259603-bh198xgl	243	48	infected	infected	JJ
cord-259603-bh198xgl	243	49	cell	cell	NN
cord-259603-bh198xgl	243	50	(	(	-LRB-
cord-259603-bh198xgl	243	51	Knoops	Knoops	NNP
cord-259603-bh198xgl	243	52	et	et	NNP
cord-259603-bh198xgl	243	53	al	al	NNP
cord-259603-bh198xgl	243	54	.	.	NNP
cord-259603-bh198xgl	243	55	,	,	,
cord-259603-bh198xgl	243	56	2008	2008	CD
cord-259603-bh198xgl	243	57	;	;	:
cord-259603-bh198xgl	243	58	V'Kovski	V'Kovski	NNP
cord-259603-bh198xgl	243	59	et	et	NNP
cord-259603-bh198xgl	243	60	al	al	NNP
cord-259603-bh198xgl	243	61	.	.	NNP
cord-259603-bh198xgl	243	62	,	,	,
cord-259603-bh198xgl	243	63	2015	2015	CD
cord-259603-bh198xgl	243	64	)	)	-RRB-
cord-259603-bh198xgl	243	65	complicate	complicate	VBP
cord-259603-bh198xgl	243	66	the	the	DT
cord-259603-bh198xgl	243	67	straightforward	straightforward	JJ
cord-259603-bh198xgl	243	68	characterization	characterization	NN
cord-259603-bh198xgl	243	69	of	of	IN
cord-259603-bh198xgl	243	70	the	the	DT
cord-259603-bh198xgl	243	71	CoV	CoV	NNP
cord-259603-bh198xgl	243	72	RdRp	RdRp	NNP
cord-259603-bh198xgl	243	73	.	.	.
cord-259603-bh198xgl	244	1	To	to	TO
cord-259603-bh198xgl	244	2	reconstitute	reconstitute	VB
cord-259603-bh198xgl	244	3	the	the	DT
cord-259603-bh198xgl	244	4	enzyme	enzyme	NN
cord-259603-bh198xgl	244	5	's	's	POS
cord-259603-bh198xgl	244	6	activities	activity	NNS
cord-259603-bh198xgl	244	7	in	in	IN
cord-259603-bh198xgl	244	8	vitro	vitro	FW
cord-259603-bh198xgl	244	9	,	,	,
cord-259603-bh198xgl	244	10	purified	purify	VBN
cord-259603-bh198xgl	244	11	recombinant	recombinant	JJ
cord-259603-bh198xgl	244	12	nsp12	nsp12	CD
cord-259603-bh198xgl	244	13	is	be	VBZ
cord-259603-bh198xgl	244	14	a	a	DT
cord-259603-bh198xgl	244	15	key	key	JJ
cord-259603-bh198xgl	244	16	reagent	reagent	NN
cord-259603-bh198xgl	244	17	but	but	CC
cord-259603-bh198xgl	244	18	,	,	,
cord-259603-bh198xgl	244	19	for	for	IN
cord-259603-bh198xgl	244	20	many	many	JJ
cord-259603-bh198xgl	244	21	years	year	NNS
cord-259603-bh198xgl	244	22	,	,	,
cord-259603-bh198xgl	244	23	such	such	JJ
cord-259603-bh198xgl	244	24	studies	study	NNS
cord-259603-bh198xgl	244	25	were	be	VBD
cord-259603-bh198xgl	244	26	hampered	hamper	VBN
cord-259603-bh198xgl	244	27	by	by	IN
cord-259603-bh198xgl	244	28	poor	poor	JJ
cord-259603-bh198xgl	244	29	nsp12	nsp12	CD
cord-259603-bh198xgl	244	30	expression	expression	NN
cord-259603-bh198xgl	244	31	in	in	IN
cord-259603-bh198xgl	244	32	Escherichia	Escherichia	NNP
cord-259603-bh198xgl	244	33	coli	coli	NNS
cord-259603-bh198xgl	244	34	.	.	.
cord-259603-bh198xgl	245	1	The	the	DT
cord-259603-bh198xgl	245	2	first	first	JJ
cord-259603-bh198xgl	245	3	in	in	IN
cord-259603-bh198xgl	245	4	vitro	vitro	FW
cord-259603-bh198xgl	245	5	activity	activity	NN
cord-259603-bh198xgl	245	6	assays	assay	NNS
cord-259603-bh198xgl	245	7	have	have	VBP
cord-259603-bh198xgl	245	8	only	only	RB
cord-259603-bh198xgl	245	9	been	be	VBN
cord-259603-bh198xgl	245	10	developed	develop	VBN
cord-259603-bh198xgl	245	11	recently	recently	RB
cord-259603-bh198xgl	246	1	(	(	-LRB-
cord-259603-bh198xgl	246	2	Subissi	Subissi	NNP
cord-259603-bh198xgl	246	3	et	et	NNP
cord-259603-bh198xgl	246	4	al	al	NNP
cord-259603-bh198xgl	246	5	.	.	NNP
cord-259603-bh198xgl	246	6	,	,	,
cord-259603-bh198xgl	246	7	2014b	2014b	CD
cord-259603-bh198xgl	246	8	;	;	:
cord-259603-bh198xgl	246	9	te	te	NNP
cord-259603-bh198xgl	246	10	Velthuis	Velthuis	NNP
cord-259603-bh198xgl	246	11	et	et	NNP
cord-259603-bh198xgl	246	12	al	al	NNP
cord-259603-bh198xgl	246	13	.	.	NNP
cord-259603-bh198xgl	246	14	,	,	,
cord-259603-bh198xgl	246	15	2010	2010	CD
cord-259603-bh198xgl	246	16	)	)	-RRB-
cord-259603-bh198xgl	246	17	,	,	,
cord-259603-bh198xgl	246	18	and	and	CC
cord-259603-bh198xgl	246	19	the	the	DT
cord-259603-bh198xgl	246	20	same	same	JJ
cord-259603-bh198xgl	246	21	technical	technical	JJ
cord-259603-bh198xgl	246	22	issues	issue	NNS
cord-259603-bh198xgl	246	23	with	with	IN
cord-259603-bh198xgl	246	24	protein	protein	NN
cord-259603-bh198xgl	246	25	production	production	NN
cord-259603-bh198xgl	246	26	explain	explain	VBP
cord-259603-bh198xgl	246	27	the	the	DT
cord-259603-bh198xgl	246	28	current	current	JJ
cord-259603-bh198xgl	246	29	lack	lack	NN
cord-259603-bh198xgl	246	30	of	of	IN
cord-259603-bh198xgl	246	31	an	an	DT
cord-259603-bh198xgl	246	32	nsp12	nsp12	CD
cord-259603-bh198xgl	246	33	crystal	crystal	NN
cord-259603-bh198xgl	246	34	structure	structure	NN
cord-259603-bh198xgl	246	35	.	.	.
cord-259603-bh198xgl	247	1	Consequently	consequently	RB
cord-259603-bh198xgl	247	2	,	,	,
cord-259603-bh198xgl	247	3	structural	structural	JJ
cord-259603-bh198xgl	247	4	information	information	NN
cord-259603-bh198xgl	247	5	is	be	VBZ
cord-259603-bh198xgl	247	6	restricted	restrict	VBN
cord-259603-bh198xgl	247	7	to	to	IN
cord-259603-bh198xgl	247	8	sequence	sequence	NN
cord-259603-bh198xgl	247	9	comparisons	comparison	NNS
cord-259603-bh198xgl	247	10	and	and	CC
cord-259603-bh198xgl	247	11	some	some	DT
cord-259603-bh198xgl	247	12	homology	homology	NN
cord-259603-bh198xgl	247	13	-	-	HYPH
cord-259603-bh198xgl	247	14	based	base	VBN
cord-259603-bh198xgl	247	15	structure	structure	NN
cord-259603-bh198xgl	247	16	models	model	NNS
cord-259603-bh198xgl	247	17	of	of	IN
cord-259603-bh198xgl	247	18	the	the	DT
cord-259603-bh198xgl	247	19	C	C	NNP
cord-259603-bh198xgl	247	20	-	-	HYPH
cord-259603-bh198xgl	247	21	terminal	terminal	NN
cord-259603-bh198xgl	247	22	RdRp	RdRp	NNP
cord-259603-bh198xgl	247	23	domain	domain	NN
cord-259603-bh198xgl	247	24	of	of	IN
cord-259603-bh198xgl	247	25	the	the	DT
cord-259603-bh198xgl	247	26	$	$	$
cord-259603-bh198xgl	247	27	930-residue	930-residue	CD
cord-259603-bh198xgl	247	28	-	-	HYPH
cord-259603-bh198xgl	247	29	long	long	JJ
cord-259603-bh198xgl	247	30	nsp12	nsp12	CD
cord-259603-bh198xgl	247	31	(	(	-LRB-
cord-259603-bh198xgl	247	32	Xu	Xu	NNP
cord-259603-bh198xgl	247	33	et	et	NNP
cord-259603-bh198xgl	247	34	al	al	NNP
cord-259603-bh198xgl	247	35	.	.	NNP
cord-259603-bh198xgl	247	36	,	,	,
cord-259603-bh198xgl	247	37	2003	2003	CD
cord-259603-bh198xgl	247	38	)	)	-RRB-
cord-259603-bh198xgl	247	39	.	.	.
cord-259603-bh198xgl	248	1	Moreover	moreover	RB
cord-259603-bh198xgl	248	2	,	,	,
cord-259603-bh198xgl	248	3	most	most	JJS
cord-259603-bh198xgl	248	4	of	of	IN
cord-259603-bh198xgl	248	5	what	what	WP
cord-259603-bh198xgl	248	6	we	-PRON-	PRP
cord-259603-bh198xgl	248	7	have	have	VBP
cord-259603-bh198xgl	248	8	learned	learn	VBN
cord-259603-bh198xgl	248	9	so	so	RB
cord-259603-bh198xgl	248	10	far	far	RB
cord-259603-bh198xgl	248	11	is	be	VBZ
cord-259603-bh198xgl	248	12	based	base	VBN
cord-259603-bh198xgl	248	13	on	on	IN
cord-259603-bh198xgl	248	14	the	the	DT
cord-259603-bh198xgl	248	15	characterization	characterization	NN
cord-259603-bh198xgl	248	16	of	of	IN
cord-259603-bh198xgl	248	17	a	a	DT
cord-259603-bh198xgl	248	18	single	single	JJ
cord-259603-bh198xgl	248	19	nsp12	nsp12	CD
cord-259603-bh198xgl	248	20	homolog	homolog	NN
cord-259603-bh198xgl	248	21	only	only	RB
cord-259603-bh198xgl	248	22	,	,	,
cord-259603-bh198xgl	248	23	that	that	DT
cord-259603-bh198xgl	248	24	of	of	IN
cord-259603-bh198xgl	248	25	the	the	DT
cord-259603-bh198xgl	248	26	SARS	SARS	NNP
cord-259603-bh198xgl	248	27	-	-	HYPH
cord-259603-bh198xgl	248	28	CoV.	CoV.	NNP
cord-259603-bh198xgl	249	1	The	the	DT
cord-259603-bh198xgl	249	2	nsp12-coding	nsp12-coding	JJ
cord-259603-bh198xgl	249	3	sequence	sequence	NN
cord-259603-bh198xgl	249	4	includes	include	VBZ
cord-259603-bh198xgl	249	5	the	the	DT
cord-259603-bh198xgl	249	6	ORF1a/1b	ORF1a/1b	NNP
cord-259603-bh198xgl	249	7	ribosomal	ribosomal	JJ
cord-259603-bh198xgl	249	8	frameshift	frameshift	NN
cord-259603-bh198xgl	249	9	site	site	NN
cord-259603-bh198xgl	249	10	and	and	CC
cord-259603-bh198xgl	249	11	a	a	DT
cord-259603-bh198xgl	249	12	programmed	program	VBN
cord-259603-bh198xgl	249	13	-1	-1	NN
cord-259603-bh198xgl	249	14	frameshifting	frameshifting	NN
cord-259603-bh198xgl	249	15	event	event	NN
cord-259603-bh198xgl	249	16	directs	direct	VBZ
cord-259603-bh198xgl	249	17	ORF1b	orf1b	JJ
cord-259603-bh198xgl	249	18	translation	translation	NN
cord-259603-bh198xgl	249	19	to	to	TO
cord-259603-bh198xgl	249	20	yield	yield	VB
cord-259603-bh198xgl	249	21	the	the	DT
cord-259603-bh198xgl	249	22	pp1ab	pp1ab	NNP
cord-259603-bh198xgl	249	23	polyprotein	polyprotein	NN
cord-259603-bh198xgl	249	24	that	that	WDT
cord-259603-bh198xgl	249	25	includes	include	VBZ
cord-259603-bh198xgl	249	26	nsp12	nsp12	CD
cord-259603-bh198xgl	249	27	.	.	.
cord-259603-bh198xgl	250	1	The	the	DT
cord-259603-bh198xgl	250	2	3CL	3cl	CD
cord-259603-bh198xgl	250	3	pro	pro	JJ
cord-259603-bh198xgl	250	4	-driven	-driven	JJ
cord-259603-bh198xgl	250	5	cleavage	cleavage	NN
cord-259603-bh198xgl	250	6	required	require	VBN
cord-259603-bh198xgl	250	7	to	to	TO
cord-259603-bh198xgl	250	8	release	release	VB
cord-259603-bh198xgl	250	9	the	the	DT
cord-259603-bh198xgl	250	10	N	n	CD
cord-259603-bh198xgl	250	11	-	-	HYPH
cord-259603-bh198xgl	250	12	terminus	terminus	NN
cord-259603-bh198xgl	250	13	of	of	IN
cord-259603-bh198xgl	250	14	nsp12	nsp12	CD
cord-259603-bh198xgl	250	15	is	be	VBZ
cord-259603-bh198xgl	250	16	the	the	DT
cord-259603-bh198xgl	250	17	same	same	JJ
cord-259603-bh198xgl	250	18	that	that	WDT
cord-259603-bh198xgl	250	19	separates	separate	VBZ
cord-259603-bh198xgl	250	20	nsp10	nsp10	PRP
cord-259603-bh198xgl	250	21	and	and	CC
cord-259603-bh198xgl	250	22	nsp11	nsp11	ADD
cord-259603-bh198xgl	250	23	.	.	.
cord-259603-bh198xgl	251	1	About	about	IN
cord-259603-bh198xgl	251	2	925	925	CD
cord-259603-bh198xgl	251	3	-	-	SYM
cord-259603-bh198xgl	251	4	940	940	CD
cord-259603-bh198xgl	251	5	amino	amino	JJ
cord-259603-bh198xgl	251	6	acids	acid	NNS
cord-259603-bh198xgl	251	7	downstream	downstream	JJ
cord-259603-bh198xgl	251	8	(	(	-LRB-
cord-259603-bh198xgl	251	9	932	932	CD
cord-259603-bh198xgl	251	10	in	in	IN
cord-259603-bh198xgl	251	11	the	the	DT
cord-259603-bh198xgl	251	12	case	case	NN
cord-259603-bh198xgl	251	13	of	of	IN
cord-259603-bh198xgl	251	14	SARS	SARS	NNP
cord-259603-bh198xgl	251	15	-	-	HYPH
cord-259603-bh198xgl	251	16	CoV	CoV	NNP
cord-259603-bh198xgl	251	17	)	)	-RRB-
cord-259603-bh198xgl	251	18	,	,	,
cord-259603-bh198xgl	251	19	the	the	DT
cord-259603-bh198xgl	251	20	nsp12	nsp12	CD
cord-259603-bh198xgl	251	21	/	/	SYM
cord-259603-bh198xgl	251	22	nsp13	nsp13	CD
cord-259603-bh198xgl	251	23	cleavage	cleavage	NN
cord-259603-bh198xgl	251	24	site	site	NN
cord-259603-bh198xgl	251	25	separates	separate	VBZ
cord-259603-bh198xgl	251	26	the	the	DT
cord-259603-bh198xgl	251	27	CoV	cov	NN
cord-259603-bh198xgl	251	28	RdRp	RdRp	NNP
cord-259603-bh198xgl	251	29	subunit	subunit	NN
cord-259603-bh198xgl	251	30	from	from	IN
cord-259603-bh198xgl	251	31	the	the	DT
cord-259603-bh198xgl	251	32	helicase	helicase	NN
cord-259603-bh198xgl	251	33	-	-	HYPH
cord-259603-bh198xgl	251	34	containing	contain	VBG
cord-259603-bh198xgl	251	35	cleavage	cleavage	NN
cord-259603-bh198xgl	251	36	product	product	NN
cord-259603-bh198xgl	251	37	,	,	,
cord-259603-bh198xgl	251	38	whichuniquely	whichuniquely	RB
cord-259603-bh198xgl	251	39	among	among	IN
cord-259603-bh198xgl	251	40	+	+	CC
cord-259603-bh198xgl	251	41	RNA	RNA	NNP
cord-259603-bh198xgl	251	42	viruses	virus	NNS
cord-259603-bh198xgl	251	43	-	-	:
cord-259603-bh198xgl	251	44	resides	reside	VBZ
cord-259603-bh198xgl	251	45	downstream	downstream	NN
cord-259603-bh198xgl	251	46	of	of	IN
cord-259603-bh198xgl	251	47	the	the	DT
cord-259603-bh198xgl	251	48	RdRp	RdRp	NNP
cord-259603-bh198xgl	251	49	domain	domain	NN
cord-259603-bh198xgl	251	50	for	for	IN
cord-259603-bh198xgl	251	51	reasons	reason	NNS
cord-259603-bh198xgl	251	52	that	that	WDT
cord-259603-bh198xgl	251	53	are	be	VBP
cord-259603-bh198xgl	251	54	poorly	poorly	RB
cord-259603-bh198xgl	251	55	understood	understand	VBN
cord-259603-bh198xgl	251	56	thus	thus	RB
cord-259603-bh198xgl	251	57	far	far	RB
cord-259603-bh198xgl	251	58	.	.	.
cord-259603-bh198xgl	252	1	Nsp12	Nsp12	NNP
cord-259603-bh198xgl	252	2	consists	consist	VBZ
cord-259603-bh198xgl	252	3	of	of	IN
cord-259603-bh198xgl	252	4	at	at	RB
cord-259603-bh198xgl	252	5	least	least	RBS
cord-259603-bh198xgl	252	6	two	two	CD
cord-259603-bh198xgl	252	7	domains	domain	NNS
cord-259603-bh198xgl	252	8	,	,	,
cord-259603-bh198xgl	252	9	the	the	DT
cord-259603-bh198xgl	252	10	recently	recently	RB
cord-259603-bh198xgl	252	11	described	describe	VBN
cord-259603-bh198xgl	252	12	N	n	CD
cord-259603-bh198xgl	252	13	-	-	HYPH
cord-259603-bh198xgl	252	14	terminal	terminal	JJ
cord-259603-bh198xgl	252	15	"	"	``
cord-259603-bh198xgl	252	16	nidovirus	nidovirus	NN
cord-259603-bh198xgl	252	17	-	-	HYPH
cord-259603-bh198xgl	252	18	wide	wide	JJ
cord-259603-bh198xgl	252	19	conserved	conserve	VBN
cord-259603-bh198xgl	252	20	domain	domain	NN
cord-259603-bh198xgl	252	21	with	with	IN
cord-259603-bh198xgl	252	22	nucleotidyl	nucleotidyl	NNP
cord-259603-bh198xgl	252	23	transferase	transferase	NNP
cord-259603-bh198xgl	252	24	activity	activity	NN
cord-259603-bh198xgl	252	25	"	"	''
cord-259603-bh198xgl	252	26	(	(	-LRB-
cord-259603-bh198xgl	252	27	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	252	28	RdRp	RdRp	NNP
cord-259603-bh198xgl	252	29	-	-	HYPH
cord-259603-bh198xgl	252	30	associated	associate	VBN
cord-259603-bh198xgl	252	31	nucleotidyltransferase	nucleotidyltransferase	NNP
cord-259603-bh198xgl	252	32	(	(	-LRB-
cord-259603-bh198xgl	252	33	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	252	34	)	)	-RRB-
cord-259603-bh198xgl	252	35	;	;	:
cord-259603-bh198xgl	252	36	see	see	VB
cord-259603-bh198xgl	252	37	later	later	RB
cord-259603-bh198xgl	252	38	)	)	-RRB-
cord-259603-bh198xgl	253	1	(	(	-LRB-
cord-259603-bh198xgl	253	2	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	253	3	et	et	NNP
cord-259603-bh198xgl	253	4	al	al	NNP
cord-259603-bh198xgl	253	5	.	.	NNP
cord-259603-bh198xgl	253	6	,	,	,
cord-259603-bh198xgl	253	7	2015a	2015a	CD
cord-259603-bh198xgl	253	8	)	)	-RRB-
cord-259603-bh198xgl	253	9	and	and	CC
cord-259603-bh198xgl	253	10	the	the	DT
cord-259603-bh198xgl	253	11	C	C	NNP
cord-259603-bh198xgl	253	12	-	-	HYPH
cord-259603-bh198xgl	253	13	terminal	terminal	NN
cord-259603-bh198xgl	253	14	canonical	canonical	JJ
cord-259603-bh198xgl	253	15	RdRp	RdRp	NNP
cord-259603-bh198xgl	253	16	domain	domain	NN
cord-259603-bh198xgl	253	17	(	(	-LRB-
cord-259603-bh198xgl	253	18	Gorbalenya	Gorbalenya	NNP
cord-259603-bh198xgl	253	19	et	et	NNP
cord-259603-bh198xgl	253	20	al	al	NNP
cord-259603-bh198xgl	253	21	.	.	NNP
cord-259603-bh198xgl	253	22	,	,	,
cord-259603-bh198xgl	253	23	1989	1989	CD
cord-259603-bh198xgl	253	24	)	)	-RRB-
cord-259603-bh198xgl	253	25	.	.	.
cord-259603-bh198xgl	254	1	The	the	DT
cord-259603-bh198xgl	254	2	latter	latter	NN
cord-259603-bh198xgl	254	3	possesses	possess	VBZ
cord-259603-bh198xgl	254	4	the	the	DT
cord-259603-bh198xgl	254	5	common	common	JJ
cord-259603-bh198xgl	254	6	motifs	motif	NNS
cord-259603-bh198xgl	254	7	and	and	CC
cord-259603-bh198xgl	254	8	structural	structural	JJ
cord-259603-bh198xgl	254	9	features	feature	NNS
cord-259603-bh198xgl	254	10	found	find	VBN
cord-259603-bh198xgl	254	11	in	in	IN
cord-259603-bh198xgl	254	12	other	other	JJ
cord-259603-bh198xgl	254	13	RNA	RNA	NNP
cord-259603-bh198xgl	254	14	polymerases	polymerase	NNS
cord-259603-bh198xgl	254	15	,	,	,
cord-259603-bh198xgl	254	16	which	which	WDT
cord-259603-bh198xgl	254	17	are	be	VBP
cord-259603-bh198xgl	254	18	often	often	RB
cord-259603-bh198xgl	254	19	summarized	summarize	VBN
cord-259603-bh198xgl	254	20	as	as	IN
cord-259603-bh198xgl	254	21	a	a	DT
cord-259603-bh198xgl	254	22	"	"	``
cord-259603-bh198xgl	254	23	cupped	cup	VBN
cord-259603-bh198xgl	254	24	right	right	JJ
cord-259603-bh198xgl	254	25	hand	hand	NN
cord-259603-bh198xgl	254	26	"	"	''
cord-259603-bh198xgl	254	27	with	with	IN
cord-259603-bh198xgl	254	28	subdomains	subdomain	NNS
cord-259603-bh198xgl	254	29	called	call	VBD
cord-259603-bh198xgl	254	30	fingers	finger	NNS
cord-259603-bh198xgl	254	31	,	,	,
cord-259603-bh198xgl	254	32	palm	palm	NN
cord-259603-bh198xgl	254	33	,	,	,
cord-259603-bh198xgl	254	34	and	and	CC
cord-259603-bh198xgl	254	35	thumb	thumb	NN
cord-259603-bh198xgl	254	36	each	each	DT
cord-259603-bh198xgl	254	37	playing	play	VBG
cord-259603-bh198xgl	254	38	specific	specific	JJ
cord-259603-bh198xgl	254	39	roles	role	NNS
cord-259603-bh198xgl	254	40	in	in	IN
cord-259603-bh198xgl	254	41	binding	binding	NN
cord-259603-bh198xgl	254	42	of	of	IN
cord-259603-bh198xgl	254	43	templates	template	NNS
cord-259603-bh198xgl	254	44	and	and	CC
cord-259603-bh198xgl	254	45	NTPs	ntp	NNS
cord-259603-bh198xgl	254	46	,	,	,
cord-259603-bh198xgl	254	47	initiation	initiation	NN
cord-259603-bh198xgl	254	48	,	,	,
cord-259603-bh198xgl	254	49	and	and	CC
cord-259603-bh198xgl	254	50	elongation	elongation	NN
cord-259603-bh198xgl	254	51	(	(	-LRB-
cord-259603-bh198xgl	254	52	te	te	NNP
cord-259603-bh198xgl	254	53	Velthuis	Velthuis	NNP
cord-259603-bh198xgl	254	54	,	,	,
cord-259603-bh198xgl	254	55	2014	2014	CD
cord-259603-bh198xgl	254	56	;	;	:
cord-259603-bh198xgl	254	57	Xu	Xu	NNP
cord-259603-bh198xgl	254	58	et	et	NNP
cord-259603-bh198xgl	254	59	al	al	NNP
cord-259603-bh198xgl	254	60	.	.	NNP
cord-259603-bh198xgl	254	61	,	,	,
cord-259603-bh198xgl	254	62	2003	2003	CD
cord-259603-bh198xgl	254	63	)	)	-RRB-
cord-259603-bh198xgl	254	64	.	.	.
cord-259603-bh198xgl	255	1	In	in	IN
cord-259603-bh198xgl	255	2	simplified	simplified	JJ
cord-259603-bh198xgl	255	3	form	form	NN
cord-259603-bh198xgl	255	4	,	,	,
cord-259603-bh198xgl	255	5	the	the	DT
cord-259603-bh198xgl	255	6	reaction	reaction	NN
cord-259603-bh198xgl	255	7	catalyzed	catalyze	VBN
cord-259603-bh198xgl	255	8	by	by	IN
cord-259603-bh198xgl	255	9	the	the	DT
cord-259603-bh198xgl	255	10	RdRp	RdRp	NNP
cord-259603-bh198xgl	255	11	comes	come	VBZ
cord-259603-bh198xgl	255	12	down	down	RP
cord-259603-bh198xgl	255	13	to	to	IN
cord-259603-bh198xgl	255	14	selecting	select	VBG
cord-259603-bh198xgl	255	15	the	the	DT
cord-259603-bh198xgl	255	16	appropriate	appropriate	JJ
cord-259603-bh198xgl	255	17	NTP	ntp	NN
cord-259603-bh198xgl	255	18	to	to	TO
cord-259603-bh198xgl	255	19	match	match	VB
cord-259603-bh198xgl	255	20	with	with	IN
cord-259603-bh198xgl	255	21	the	the	DT
cord-259603-bh198xgl	255	22	template	template	NN
cord-259603-bh198xgl	255	23	and	and	CC
cord-259603-bh198xgl	255	24	the	the	DT
cord-259603-bh198xgl	255	25	formation	formation	NN
cord-259603-bh198xgl	255	26	of	of	IN
cord-259603-bh198xgl	255	27	a	a	DT
cord-259603-bh198xgl	255	28	phosphodiester	phosphodiester	NN
cord-259603-bh198xgl	255	29	bond	bond	NN
cord-259603-bh198xgl	255	30	to	to	TO
cord-259603-bh198xgl	255	31	extend	extend	VB
cord-259603-bh198xgl	255	32	the	the	DT
cord-259603-bh198xgl	255	33	3	3	CD
cord-259603-bh198xgl	255	34	0	0	CD
cord-259603-bh198xgl	255	35	end	end	NN
cord-259603-bh198xgl	255	36	of	of	IN
cord-259603-bh198xgl	255	37	the	the	DT
cord-259603-bh198xgl	255	38	nascent	nascent	JJ
cord-259603-bh198xgl	255	39	RNA	RNA	NNP
cord-259603-bh198xgl	255	40	chain	chain	NN
cord-259603-bh198xgl	255	41	with	with	IN
cord-259603-bh198xgl	255	42	this	this	DT
cord-259603-bh198xgl	255	43	incoming	incoming	JJ
cord-259603-bh198xgl	255	44	nucleotide	nucleotide	NN
cord-259603-bh198xgl	255	45	(	(	-LRB-
cord-259603-bh198xgl	255	46	Ng	Ng	NNP
cord-259603-bh198xgl	255	47	et	et	FW
cord-259603-bh198xgl	255	48	al	al	NNP
cord-259603-bh198xgl	255	49	.	.	NNP
cord-259603-bh198xgl	255	50	,	,	,
cord-259603-bh198xgl	255	51	2008	2008	CD
cord-259603-bh198xgl	255	52	;	;	:
cord-259603-bh198xgl	255	53	van	van	NNP
cord-259603-bh198xgl	255	54	Dijk	Dijk	NNP
cord-259603-bh198xgl	255	55	et	et	NNP
cord-259603-bh198xgl	255	56	al	al	NNP
cord-259603-bh198xgl	255	57	.	.	NNP
cord-259603-bh198xgl	255	58	,	,	,
cord-259603-bh198xgl	255	59	2004	2004	CD
cord-259603-bh198xgl	255	60	)	)	-RRB-
cord-259603-bh198xgl	255	61	.	.	.
cord-259603-bh198xgl	256	1	Reconstituting	reconstitute	VBG
cord-259603-bh198xgl	256	2	these	these	DT
cord-259603-bh198xgl	256	3	activities	activity	NNS
cord-259603-bh198xgl	256	4	in	in	IN
cord-259603-bh198xgl	256	5	vitro	vitro	FW
cord-259603-bh198xgl	256	6	using	use	VBG
cord-259603-bh198xgl	256	7	a	a	DT
cord-259603-bh198xgl	256	8	purified	purify	VBN
cord-259603-bh198xgl	256	9	RdRp	rdrp	NN
cord-259603-bh198xgl	256	10	preparation	preparation	NN
cord-259603-bh198xgl	256	11	can	can	MD
cord-259603-bh198xgl	256	12	be	be	VB
cord-259603-bh198xgl	256	13	relatively	relatively	RB
cord-259603-bh198xgl	256	14	straightforward	straightforward	JJ
cord-259603-bh198xgl	256	15	,	,	,
cord-259603-bh198xgl	256	16	but	but	CC
cord-259603-bh198xgl	256	17	sometimes	sometimes	RB
cord-259603-bh198xgl	256	18	is	be	VBZ
cord-259603-bh198xgl	256	19	a	a	DT
cord-259603-bh198xgl	256	20	huge	huge	JJ
cord-259603-bh198xgl	256	21	technical	technical	JJ
cord-259603-bh198xgl	256	22	challenge	challenge	NN
cord-259603-bh198xgl	256	23	depending	depending	NN
cord-259603-bh198xgl	256	24	-	-	:
cord-259603-bh198xgl	256	25	among	among	IN
cord-259603-bh198xgl	256	26	other	other	JJ
cord-259603-bh198xgl	256	27	factors	factor	NNS
cord-259603-bh198xgl	256	28	-	-	:
cord-259603-bh198xgl	256	29	on	on	IN
cord-259603-bh198xgl	256	30	the	the	DT
cord-259603-bh198xgl	256	31	efficiency	efficiency	NN
cord-259603-bh198xgl	256	32	of	of	IN
cord-259603-bh198xgl	256	33	recombinant	recombinant	JJ
cord-259603-bh198xgl	256	34	RdRp	RdRp	NNP
cord-259603-bh198xgl	256	35	expression	expression	NN
cord-259603-bh198xgl	256	36	and	and	CC
cord-259603-bh198xgl	256	37	purification	purification	NN
cord-259603-bh198xgl	256	38	,	,	,
cord-259603-bh198xgl	256	39	the	the	DT
cord-259603-bh198xgl	256	40	existence	existence	NN
cord-259603-bh198xgl	256	41	of	of	IN
cord-259603-bh198xgl	256	42	specific	specific	JJ
cord-259603-bh198xgl	256	43	template	template	NN
cord-259603-bh198xgl	256	44	requirements	requirement	NNS
cord-259603-bh198xgl	256	45	(	(	-LRB-
cord-259603-bh198xgl	256	46	e.g.	e.g.	RB
cord-259603-bh198xgl	256	47	,	,	,
cord-259603-bh198xgl	256	48	recognition	recognition	NN
cord-259603-bh198xgl	256	49	signals	signal	NNS
cord-259603-bh198xgl	256	50	)	)	-RRB-
cord-259603-bh198xgl	256	51	,	,	,
cord-259603-bh198xgl	256	52	and	and	CC
cord-259603-bh198xgl	256	53	the	the	DT
cord-259603-bh198xgl	256	54	need	need	NN
cord-259603-bh198xgl	256	55	for	for	IN
cord-259603-bh198xgl	256	56	protein	protein	NN
cord-259603-bh198xgl	256	57	cofactors	cofactor	NNS
cord-259603-bh198xgl	256	58	.	.	.
cord-259603-bh198xgl	257	1	The	the	DT
cord-259603-bh198xgl	257	2	initiation	initiation	NN
cord-259603-bh198xgl	257	3	mechanism	mechanism	NN
cord-259603-bh198xgl	257	4	of	of	IN
cord-259603-bh198xgl	257	5	the	the	DT
cord-259603-bh198xgl	257	6	CoV	CoV	NNP
cord-259603-bh198xgl	257	7	RdRp	RdRp	NNP
cord-259603-bh198xgl	257	8	,	,	,
cord-259603-bh198xgl	257	9	primer	primer	NN
cord-259603-bh198xgl	257	10	dependent	dependent	JJ
cord-259603-bh198xgl	257	11	or	or	CC
cord-259603-bh198xgl	257	12	de	de	FW
cord-259603-bh198xgl	257	13	novo	novo	NNP
cord-259603-bh198xgl	257	14	,	,	,
cord-259603-bh198xgl	257	15	continues	continue	VBZ
cord-259603-bh198xgl	257	16	to	to	TO
cord-259603-bh198xgl	257	17	be	be	VB
cord-259603-bh198xgl	257	18	a	a	DT
cord-259603-bh198xgl	257	19	much	much	RB
cord-259603-bh198xgl	257	20	-	-	HYPH
cord-259603-bh198xgl	257	21	debated	debate	VBN
cord-259603-bh198xgl	257	22	issue	issue	NN
cord-259603-bh198xgl	257	23	,	,	,
cord-259603-bh198xgl	257	24	with	with	IN
cord-259603-bh198xgl	257	25	important	important	JJ
cord-259603-bh198xgl	257	26	implications	implication	NNS
cord-259603-bh198xgl	257	27	for	for	IN
cord-259603-bh198xgl	257	28	the	the	DT
cord-259603-bh198xgl	257	29	question	question	NN
cord-259603-bh198xgl	257	30	of	of	IN
cord-259603-bh198xgl	257	31	how	how	WRB
cord-259603-bh198xgl	257	32	CoVs	CoVs	NNP
cord-259603-bh198xgl	257	33	maintain	maintain	VBP
cord-259603-bh198xgl	257	34	the	the	DT
cord-259603-bh198xgl	257	35	integrity	integrity	NN
cord-259603-bh198xgl	257	36	of	of	IN
cord-259603-bh198xgl	257	37	the	the	DT
cord-259603-bh198xgl	257	38	crucial	crucial	JJ
cord-259603-bh198xgl	257	39	terminal	terminal	NN
cord-259603-bh198xgl	257	40	sequences	sequence	NNS
cord-259603-bh198xgl	257	41	of	of	IN
cord-259603-bh198xgl	257	42	their	-PRON-	PRP$
cord-259603-bh198xgl	257	43	genome	genome	NN
cord-259603-bh198xgl	257	44	.	.	.
cord-259603-bh198xgl	258	1	Compared	compare	VBN
cord-259603-bh198xgl	258	2	to	to	IN
cord-259603-bh198xgl	258	3	a	a	DT
cord-259603-bh198xgl	258	4	de	de	FW
cord-259603-bh198xgl	258	5	novo	novo	NN
cord-259603-bh198xgl	258	6	-	-	HYPH
cord-259603-bh198xgl	258	7	initiating	initiate	VBG
cord-259603-bh198xgl	258	8	RdRp	RdRp	NNP
cord-259603-bh198xgl	258	9	,	,	,
cord-259603-bh198xgl	258	10	the	the	DT
cord-259603-bh198xgl	258	11	enzyme	enzyme	NN
cord-259603-bh198xgl	258	12	's	's	POS
cord-259603-bh198xgl	258	13	active	active	JJ
cord-259603-bh198xgl	258	14	site	site	NN
cord-259603-bh198xgl	258	15	,	,	,
cord-259603-bh198xgl	258	16	which	which	WDT
cord-259603-bh198xgl	258	17	is	be	VBZ
cord-259603-bh198xgl	258	18	enclosed	enclose	VBN
cord-259603-bh198xgl	258	19	by	by	IN
cord-259603-bh198xgl	258	20	the	the	DT
cord-259603-bh198xgl	258	21	thumb	thumb	NN
cord-259603-bh198xgl	258	22	and	and	CC
cord-259603-bh198xgl	258	23	fingers	finger	NNS
cord-259603-bh198xgl	258	24	domains	domain	NNS
cord-259603-bh198xgl	258	25	,	,	,
cord-259603-bh198xgl	258	26	needs	need	VBZ
cord-259603-bh198xgl	258	27	to	to	TO
cord-259603-bh198xgl	258	28	be	be	VB
cord-259603-bh198xgl	258	29	more	more	RBR
cord-259603-bh198xgl	258	30	accessible	accessible	JJ
cord-259603-bh198xgl	258	31	when	when	WRB
cord-259603-bh198xgl	258	32	a	a	DT
cord-259603-bh198xgl	258	33	primer	primer	NN
cord-259603-bh198xgl	258	34	-	-	HYPH
cord-259603-bh198xgl	258	35	template	template	NN
cord-259603-bh198xgl	258	36	duplex	duplex	NN
cord-259603-bh198xgl	258	37	has	have	VBZ
cord-259603-bh198xgl	258	38	to	to	TO
cord-259603-bh198xgl	258	39	be	be	VB
cord-259603-bh198xgl	258	40	accommodated	accommodate	VBN
cord-259603-bh198xgl	258	41	.	.	.
cord-259603-bh198xgl	259	1	De	De	NNP
cord-259603-bh198xgl	259	2	novo	novo	NNP
cord-259603-bh198xgl	259	3	initiation	initiation	NN
cord-259603-bh198xgl	259	4	,	,	,
cord-259603-bh198xgl	259	5	on	on	IN
cord-259603-bh198xgl	259	6	the	the	DT
cord-259603-bh198xgl	259	7	other	other	JJ
cord-259603-bh198xgl	259	8	hand	hand	NN
cord-259603-bh198xgl	259	9	,	,	,
cord-259603-bh198xgl	259	10	requires	require	VBZ
cord-259603-bh198xgl	259	11	specific	specific	JJ
cord-259603-bh198xgl	259	12	structural	structural	JJ
cord-259603-bh198xgl	259	13	elements	element	NNS
cord-259603-bh198xgl	259	14	(	(	-LRB-
cord-259603-bh198xgl	259	15	so	so	RB
cord-259603-bh198xgl	259	16	-	-	HYPH
cord-259603-bh198xgl	259	17	called	call	VBN
cord-259603-bh198xgl	259	18	"	"	``
cord-259603-bh198xgl	259	19	priming	prime	VBG
cord-259603-bh198xgl	259	20	loops	loop	NNS
cord-259603-bh198xgl	259	21	"	"	''
cord-259603-bh198xgl	259	22	)	)	-RRB-
cord-259603-bh198xgl	259	23	that	that	WDT
cord-259603-bh198xgl	259	24	serve	serve	VBP
cord-259603-bh198xgl	259	25	to	to	TO
cord-259603-bh198xgl	259	26	properly	properly	RB
cord-259603-bh198xgl	259	27	position	position	VB
cord-259603-bh198xgl	259	28	the	the	DT
cord-259603-bh198xgl	259	29	initiating	initiate	VBG
cord-259603-bh198xgl	259	30	NTPs	ntp	NNS
cord-259603-bh198xgl	259	31	for	for	IN
cord-259603-bh198xgl	259	32	catalysis	catalysis	NN
cord-259603-bh198xgl	259	33	,	,	,
cord-259603-bh198xgl	259	34	thus	thus	RB
cord-259603-bh198xgl	259	35	creating	create	VBG
cord-259603-bh198xgl	259	36	an	an	DT
cord-259603-bh198xgl	259	37	initiation	initiation	NN
cord-259603-bh198xgl	259	38	platform	platform	NN
cord-259603-bh198xgl	259	39	for	for	IN
cord-259603-bh198xgl	259	40	RNA	RNA	NNP
cord-259603-bh198xgl	259	41	synthesis	synthesis	NN
cord-259603-bh198xgl	259	42	.	.	.
cord-259603-bh198xgl	260	1	Bioinformatics	bioinformatics	NN
cord-259603-bh198xgl	260	2	analyses	analysis	NNS
cord-259603-bh198xgl	260	3	grouped	grouped	VBP
cord-259603-bh198xgl	260	4	the	the	DT
cord-259603-bh198xgl	260	5	CoV	cov	NN
cord-259603-bh198xgl	260	6	RdRp	RdRp	NNP
cord-259603-bh198xgl	260	7	with	with	IN
cord-259603-bh198xgl	260	8	primer	primer	NN
cord-259603-bh198xgl	260	9	-	-	HYPH
cord-259603-bh198xgl	260	10	dependent	dependent	JJ
cord-259603-bh198xgl	260	11	RdRps	RdRps	NNP
cord-259603-bh198xgl	260	12	,	,	,
cord-259603-bh198xgl	260	13	as	as	IN
cord-259603-bh198xgl	260	14	found	find	VBN
cord-259603-bh198xgl	260	15	in	in	RB
cord-259603-bh198xgl	260	16	,	,	,
cord-259603-bh198xgl	260	17	e.g.	e.g.	RB
cord-259603-bh198xgl	260	18	,	,	,
cord-259603-bh198xgl	260	19	picornaviruses	picornavirus	NNS
cord-259603-bh198xgl	260	20	and	and	CC
cord-259603-bh198xgl	260	21	caliciviruses	caliciviruse	NNS
cord-259603-bh198xgl	260	22	,	,	,
cord-259603-bh198xgl	260	23	in	in	IN
cord-259603-bh198xgl	260	24	part	part	NN
cord-259603-bh198xgl	260	25	based	base	VBN
cord-259603-bh198xgl	260	26	on	on	IN
cord-259603-bh198xgl	260	27	the	the	DT
cord-259603-bh198xgl	260	28	identification	identification	NN
cord-259603-bh198xgl	260	29	of	of	IN
cord-259603-bh198xgl	260	30	a	a	DT
cord-259603-bh198xgl	260	31	specific	specific	JJ
cord-259603-bh198xgl	260	32	sequence	sequence	NN
cord-259603-bh198xgl	260	33	motif	motif	NN
cord-259603-bh198xgl	260	34	(	(	-LRB-
cord-259603-bh198xgl	260	35	motif	motif	NN
cord-259603-bh198xgl	260	36	G	G	NNP
cord-259603-bh198xgl	260	37	)	)	-RRB-
cord-259603-bh198xgl	260	38	that	that	WDT
cord-259603-bh198xgl	260	39	is	be	VBZ
cord-259603-bh198xgl	260	40	thought	think	VBN
cord-259603-bh198xgl	260	41	to	to	TO
cord-259603-bh198xgl	260	42	mediate	mediate	VB
cord-259603-bh198xgl	260	43	primer	primer	NN
cord-259603-bh198xgl	260	44	recognition	recognition	NN
cord-259603-bh198xgl	261	1	(	(	-LRB-
cord-259603-bh198xgl	261	2	Fig	Fig	NNP
cord-259603-bh198xgl	261	3	.	.	.
cord-259603-bh198xgl	261	4	3A	3A	NNP
cord-259603-bh198xgl	261	5	)	)	-RRB-
cord-259603-bh198xgl	262	1	(	(	-LRB-
cord-259603-bh198xgl	262	2	Beerens	Beerens	NNP
cord-259603-bh198xgl	262	3	et	et	NNP
cord-259603-bh198xgl	262	4	al	al	NNP
cord-259603-bh198xgl	262	5	.	.	NNP
cord-259603-bh198xgl	262	6	,	,	,
cord-259603-bh198xgl	262	7	2007	2007	CD
cord-259603-bh198xgl	262	8	;	;	.
cord-259603-bh198xgl	263	1	Fig	Fig	NNP
cord-259603-bh198xgl	263	2	.	.	.
cord-259603-bh198xgl	264	1	3	3	CD
cord-259603-bh198xgl	264	2	Comparison	comparison	NN
cord-259603-bh198xgl	264	3	of	of	IN
cord-259603-bh198xgl	264	4	coronavirus	coronavirus	NN
cord-259603-bh198xgl	264	5	nsp12	nsp12	CD
cord-259603-bh198xgl	264	6	and	and	CC
cord-259603-bh198xgl	264	7	arterivirus	arterivirus	NNP
cord-259603-bh198xgl	264	8	nsp9	nsp9	NNP
cord-259603-bh198xgl	264	9	,	,	,
cord-259603-bh198xgl	264	10	containing	contain	VBG
cord-259603-bh198xgl	264	11	the	the	DT
cord-259603-bh198xgl	264	12	highly	highly	RB
cord-259603-bh198xgl	264	13	conserved	conserve	VBN
cord-259603-bh198xgl	264	14	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	264	15	and	and	CC
cord-259603-bh198xgl	264	16	RdRp	RdRp	NNP
cord-259603-bh198xgl	264	17	domains	domain	NNS
cord-259603-bh198xgl	264	18	.	.	.
cord-259603-bh198xgl	265	1	(	(	-LRB-
cord-259603-bh198xgl	265	2	A	a	DT
cord-259603-bh198xgl	265	3	)	)	-RRB-
cord-259603-bh198xgl	265	4	Similarity	similarity	NN
cord-259603-bh198xgl	265	5	density	density	NN
cord-259603-bh198xgl	265	6	plot	plot	NN
cord-259603-bh198xgl	265	7	derived	derive	VBN
cord-259603-bh198xgl	265	8	from	from	IN
cord-259603-bh198xgl	265	9	a	a	DT
cord-259603-bh198xgl	265	10	multiple	multiple	JJ
cord-259603-bh198xgl	265	11	sequence	sequence	NN
cord-259603-bh198xgl	265	12	alignment	alignment	NN
cord-259603-bh198xgl	265	13	including	include	VBG
cord-259603-bh198xgl	265	14	RdRp	RdRp	NNP
cord-259603-bh198xgl	265	15	subunits	subunit	NNS
cord-259603-bh198xgl	265	16	from	from	IN
cord-259603-bh198xgl	265	17	all	all	DT
cord-259603-bh198xgl	265	18	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	265	19	lineages	lineage	NNS
cord-259603-bh198xgl	265	20	.	.	.
cord-259603-bh198xgl	266	1	To	to	TO
cord-259603-bh198xgl	266	2	highlight	highlight	VB
cord-259603-bh198xgl	266	3	local	local	JJ
cord-259603-bh198xgl	266	4	deviations	deviation	NNS
cord-259603-bh198xgl	266	5	from	from	IN
cord-259603-bh198xgl	266	6	the	the	DT
cord-259603-bh198xgl	266	7	average	average	JJ
cord-259603-bh198xgl	266	8	,	,	,
cord-259603-bh198xgl	266	9	areas	area	NNS
cord-259603-bh198xgl	266	10	displaying	display	VBG
cord-259603-bh198xgl	266	11	conservation	conservation	NN
cord-259603-bh198xgl	266	12	above	above	IN
cord-259603-bh198xgl	266	13	and	and	CC
cord-259603-bh198xgl	266	14	below	below	IN
cord-259603-bh198xgl	266	15	the	the	DT
cord-259603-bh198xgl	266	16	mean	mean	JJ
cord-259603-bh198xgl	266	17	similarity	similarity	NN
cord-259603-bh198xgl	266	18	are	be	VBP
cord-259603-bh198xgl	266	19	shaded	shade	VBN
cord-259603-bh198xgl	266	20	in	in	IN
cord-259603-bh198xgl	266	21	black	black	JJ
cord-259603-bh198xgl	266	22	and	and	CC
cord-259603-bh198xgl	266	23	gray	gray	JJ
cord-259603-bh198xgl	266	24	,	,	,
cord-259603-bh198xgl	266	25	respectively	respectively	RB
cord-259603-bh198xgl	266	26	.	.	.
cord-259603-bh198xgl	267	1	Conserved	conserved	JJ
cord-259603-bh198xgl	267	2	sequence	sequence	NN
cord-259603-bh198xgl	267	3	motifs	motif	NNS
cord-259603-bh198xgl	267	4	of	of	IN
cord-259603-bh198xgl	267	5	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	267	6	(	(	-LRB-
cord-259603-bh198xgl	267	7	subscript	subscript	NN
cord-259603-bh198xgl	267	8	N	n	NN
cord-259603-bh198xgl	267	9	;	;	:
cord-259603-bh198xgl	267	10	see	see	VB
cord-259603-bh198xgl	267	11	also	also	RB
cord-259603-bh198xgl	267	12	B	B	NNP
cord-259603-bh198xgl	267	13	)	)	-RRB-
cord-259603-bh198xgl	267	14	and	and	CC
cord-259603-bh198xgl	267	15	RdRp	RdRp	NNP
cord-259603-bh198xgl	267	16	(	(	-LRB-
cord-259603-bh198xgl	267	17	subscript	subscript	NN
cord-259603-bh198xgl	267	18	R	r	NN
cord-259603-bh198xgl	267	19	)	)	-RRB-
cord-259603-bh198xgl	267	20	are	be	VBP
cord-259603-bh198xgl	267	21	labeled	label	VBN
cord-259603-bh198xgl	267	22	.	.	.
cord-259603-bh198xgl	268	1	Domain	domain	NN
cord-259603-bh198xgl	268	2	boundaries	boundary	NNS
cord-259603-bh198xgl	268	3	used	use	VBN
cord-259603-bh198xgl	268	4	for	for	IN
cord-259603-bh198xgl	268	5	bioinformatics	bioinformatics	NN
cord-259603-bh198xgl	268	6	analyses	analysis	NNS
cord-259603-bh198xgl	268	7	and	and	CC
cord-259603-bh198xgl	268	8	uncertainty	uncertainty	NN
cord-259603-bh198xgl	268	9	with	with	IN
cord-259603-bh198xgl	268	10	respect	respect	NN
cord-259603-bh198xgl	268	11	to	to	IN
cord-259603-bh198xgl	268	12	the	the	DT
cord-259603-bh198xgl	268	13	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	268	14	/	/	SYM
cord-259603-bh198xgl	268	15	RdRp	RdRp	NNP
cord-259603-bh198xgl	268	16	domain	domain	NN
cord-259603-bh198xgl	268	17	boundary	boundary	NN
cord-259603-bh198xgl	268	18	are	be	VBP
cord-259603-bh198xgl	268	19	indicated	indicate	VBN
cord-259603-bh198xgl	268	20	with	with	IN
cord-259603-bh198xgl	268	21	vertical	vertical	JJ
cord-259603-bh198xgl	268	22	and	and	CC
cord-259603-bh198xgl	268	23	by	by	IN
cord-259603-bh198xgl	268	24	dashed	dash	VBN
cord-259603-bh198xgl	268	25	horizontal	horizontal	JJ
cord-259603-bh198xgl	268	26	lines	line	NNS
cord-259603-bh198xgl	268	27	,	,	,
cord-259603-bh198xgl	268	28	respectively	respectively	RB
cord-259603-bh198xgl	268	29	.	.	.
cord-259603-bh198xgl	269	1	Below	below	IN
cord-259603-bh198xgl	269	2	each	each	DT
cord-259603-bh198xgl	269	3	plot	plot	NN
cord-259603-bh198xgl	269	4	,	,	,
cord-259603-bh198xgl	269	5	the	the	DT
cord-259603-bh198xgl	269	6	predicted	predict	VBN
cord-259603-bh198xgl	269	7	secondary	secondary	JJ
cord-259603-bh198xgl	269	8	structure	structure	NN
cord-259603-bh198xgl	269	9	elements	element	NNS
cord-259603-bh198xgl	269	10	are	be	VBP
cord-259603-bh198xgl	269	11	presented	present	VBN
cord-259603-bh198xgl	269	12	in	in	IN
cord-259603-bh198xgl	269	13	gray	gray	NN
cord-259603-bh198xgl	269	14	for	for	IN
cord-259603-bh198xgl	269	15	α	α	NN
cord-259603-bh198xgl	269	16	-	-	HYPH
cord-259603-bh198xgl	269	17	helices	helix	NNS
cord-259603-bh198xgl	269	18	and	and	CC
cord-259603-bh198xgl	269	19	black	black	JJ
cord-259603-bh198xgl	269	20	for	for	IN
cord-259603-bh198xgl	269	21	β	β	NN
cord-259603-bh198xgl	269	22	-	-	HYPH
cord-259603-bh198xgl	269	23	strands	strand	NNS
cord-259603-bh198xgl	269	24	.	.	.
cord-259603-bh198xgl	270	1	Gorbalenya	Gorbalenya	NNP
cord-259603-bh198xgl	270	2	et	et	NNP
cord-259603-bh198xgl	270	3	al	al	NNP
cord-259603-bh198xgl	270	4	.	.	.
cord-259603-bh198xgl	271	1	,	,	,
cord-259603-bh198xgl	271	2	2002	2002	CD
cord-259603-bh198xgl	271	3	;	;	:
cord-259603-bh198xgl	271	4	Xu	Xu	NNP
cord-259603-bh198xgl	271	5	et	et	NNP
cord-259603-bh198xgl	271	6	al	al	NNP
cord-259603-bh198xgl	271	7	.	.	NNP
cord-259603-bh198xgl	271	8	,	,	,
cord-259603-bh198xgl	271	9	2003	2003	CD
cord-259603-bh198xgl	271	10	)	)	-RRB-
cord-259603-bh198xgl	271	11	.	.	.
cord-259603-bh198xgl	272	1	This	this	DT
cord-259603-bh198xgl	272	2	prediction	prediction	NN
cord-259603-bh198xgl	272	3	appeared	appear	VBD
cord-259603-bh198xgl	272	4	to	to	TO
cord-259603-bh198xgl	272	5	be	be	VB
cord-259603-bh198xgl	272	6	further	further	RB
cord-259603-bh198xgl	272	7	supported	support	VBN
cord-259603-bh198xgl	272	8	by	by	IN
cord-259603-bh198xgl	272	9	the	the	DT
cord-259603-bh198xgl	272	10	identification	identification	NN
cord-259603-bh198xgl	272	11	of	of	IN
cord-259603-bh198xgl	272	12	SARS	SARS	NNP
cord-259603-bh198xgl	272	13	-	-	HYPH
cord-259603-bh198xgl	272	14	CoV	CoV	NNP
cord-259603-bh198xgl	272	15	nsp8	nsp8	NN
cord-259603-bh198xgl	272	16	as	as	IN
cord-259603-bh198xgl	272	17	a	a	DT
cord-259603-bh198xgl	272	18	de	de	FW
cord-259603-bh198xgl	272	19	novoinitiating	novoinitiate	VBG
cord-259603-bh198xgl	272	20	second	second	JJ
cord-259603-bh198xgl	272	21	RNA	RNA	NNP
cord-259603-bh198xgl	272	22	polymerase	polymerase	NN
cord-259603-bh198xgl	272	23	(	(	-LRB-
cord-259603-bh198xgl	272	24	see	see	VB
cord-259603-bh198xgl	272	25	earlier	early	RBR
cord-259603-bh198xgl	272	26	)	)	-RRB-
cord-259603-bh198xgl	272	27	,	,	,
cord-259603-bh198xgl	272	28	capable	capable	JJ
cord-259603-bh198xgl	272	29	of	of	IN
cord-259603-bh198xgl	272	30	synthesizing	synthesize	VBG
cord-259603-bh198xgl	272	31	products	product	NNS
cord-259603-bh198xgl	272	32	of	of	IN
cord-259603-bh198xgl	272	33	up	up	IN
cord-259603-bh198xgl	272	34	to	to	TO
cord-259603-bh198xgl	272	35	six	six	CD
cord-259603-bh198xgl	272	36	nucleotides	nucleotide	NNS
cord-259603-bh198xgl	272	37	in	in	IN
cord-259603-bh198xgl	272	38	length	length	NN
cord-259603-bh198xgl	272	39	that	that	WDT
cord-259603-bh198xgl	272	40	could	could	MD
cord-259603-bh198xgl	272	41	serve	serve	VB
cord-259603-bh198xgl	272	42	to	to	IN
cord-259603-bh198xgl	272	43	prime	prime	NNP
cord-259603-bh198xgl	272	44	RNA	RNA	NNP
cord-259603-bh198xgl	272	45	synthesis	synthesis	NN
cord-259603-bh198xgl	272	46	by	by	IN
cord-259603-bh198xgl	272	47	the	the	DT
cord-259603-bh198xgl	272	48	nsp12-RdRp	nsp12-RdRp	NNS
cord-259603-bh198xgl	272	49	(	(	-LRB-
cord-259603-bh198xgl	272	50	Imbert	Imbert	NNP
cord-259603-bh198xgl	272	51	et	et	FW
cord-259603-bh198xgl	272	52	al	al	NNP
cord-259603-bh198xgl	272	53	.	.	NNP
cord-259603-bh198xgl	272	54	,	,	,
cord-259603-bh198xgl	272	55	2006	2006	CD
cord-259603-bh198xgl	272	56	)	)	-RRB-
cord-259603-bh198xgl	272	57	.	.	.
cord-259603-bh198xgl	273	1	Support	support	NN
cord-259603-bh198xgl	273	2	for	for	IN
cord-259603-bh198xgl	273	3	a	a	DT
cord-259603-bh198xgl	273	4	direct	direct	JJ
cord-259603-bh198xgl	273	5	interaction	interaction	NN
cord-259603-bh198xgl	273	6	between	between	IN
cord-259603-bh198xgl	273	7	nsp8	nsp8	NN
cord-259603-bh198xgl	273	8	and	and	CC
cord-259603-bh198xgl	273	9	nsp12	nsp12	NNP
cord-259603-bh198xgl	273	10	was	be	VBD
cord-259603-bh198xgl	273	11	obtained	obtain	VBN
cord-259603-bh198xgl	273	12	using	use	VBG
cord-259603-bh198xgl	273	13	different	different	JJ
cord-259603-bh198xgl	273	14	technical	technical	JJ
cord-259603-bh198xgl	273	15	approaches	approach	NNS
cord-259603-bh198xgl	273	16	Subissi	Subissi	NNP
cord-259603-bh198xgl	273	17	et	et	NNP
cord-259603-bh198xgl	273	18	al	al	NNP
cord-259603-bh198xgl	273	19	.	.	NNP
cord-259603-bh198xgl	273	20	,	,	,
cord-259603-bh198xgl	273	21	2014b	2014b	CD
cord-259603-bh198xgl	273	22	;	;	:
cord-259603-bh198xgl	273	23	von	von	NNP
cord-259603-bh198xgl	273	24	Brunn	Brunn	NNP
cord-259603-bh198xgl	273	25	et	et	NNP
cord-259603-bh198xgl	273	26	al	al	NNP
cord-259603-bh198xgl	273	27	.	.	NNP
cord-259603-bh198xgl	273	28	,	,	,
cord-259603-bh198xgl	273	29	2007	2007	CD
cord-259603-bh198xgl	273	30	)	)	-RRB-
cord-259603-bh198xgl	273	31	.	.	.
cord-259603-bh198xgl	274	1	However	however	RB
cord-259603-bh198xgl	274	2	,	,	,
cord-259603-bh198xgl	274	3	although	although	IN
cord-259603-bh198xgl	274	4	a	a	DT
cord-259603-bh198xgl	274	5	similar	similar	JJ
cord-259603-bh198xgl	274	6	primer	primer	NN
cord-259603-bh198xgl	274	7	-	-	HYPH
cord-259603-bh198xgl	274	8	independent	independent	JJ
cord-259603-bh198xgl	274	9	RdRp	RdRp	NNP
cord-259603-bh198xgl	274	10	activity	activity	NN
cord-259603-bh198xgl	274	11	was	be	VBD
cord-259603-bh198xgl	274	12	reported	report	VBN
cord-259603-bh198xgl	274	13	for	for	IN
cord-259603-bh198xgl	274	14	the	the	DT
cord-259603-bh198xgl	274	15	FCoV	FCoV	NNP
cord-259603-bh198xgl	274	16	nsp8	nsp8	NN
cord-259603-bh198xgl	275	1	(	(	-LRB-
cord-259603-bh198xgl	275	2	Xiao	Xiao	NNP
cord-259603-bh198xgl	275	3	et	et	NNP
cord-259603-bh198xgl	275	4	al	al	NNP
cord-259603-bh198xgl	275	5	.	.	.
cord-259603-bh198xgl	276	1	,	,	,
cord-259603-bh198xgl	276	2	2012	2012	CD
cord-259603-bh198xgl	276	3	)	)	-RRB-
cord-259603-bh198xgl	276	4	,	,	,
cord-259603-bh198xgl	276	5	other	other	JJ
cord-259603-bh198xgl	276	6	studies	study	NNS
cord-259603-bh198xgl	276	7	have	have	VBP
cord-259603-bh198xgl	276	8	called	call	VBN
cord-259603-bh198xgl	276	9	into	into	IN
cord-259603-bh198xgl	276	10	question	question	NN
cord-259603-bh198xgl	276	11	this	this	DT
cord-259603-bh198xgl	276	12	concept	concept	NN
cord-259603-bh198xgl	276	13	of	of	IN
cord-259603-bh198xgl	276	14	a	a	DT
cord-259603-bh198xgl	276	15	primase	primase	JJ
cord-259603-bh198xgl	276	16	-	-	HYPH
cord-259603-bh198xgl	276	17	main	main	JJ
cord-259603-bh198xgl	276	18	RdRp	rdrp	NN
cord-259603-bh198xgl	276	19	(	(	-LRB-
cord-259603-bh198xgl	276	20	i.e.	i.e.	FW
cord-259603-bh198xgl	276	21	,	,	,
cord-259603-bh198xgl	276	22	nsp8	nsp8	NNP
cord-259603-bh198xgl	276	23	/	/	SYM
cord-259603-bh198xgl	276	24	nsp12	nsp12	CD
cord-259603-bh198xgl	276	25	)	)	-RRB-
cord-259603-bh198xgl	276	26	tandem	tandem	NN
cord-259603-bh198xgl	276	27	working	work	VBG
cord-259603-bh198xgl	276	28	in	in	IN
cord-259603-bh198xgl	276	29	concert	concert	NN
cord-259603-bh198xgl	276	30	to	to	TO
cord-259603-bh198xgl	276	31	achieve	achieve	VB
cord-259603-bh198xgl	276	32	initiation	initiation	NN
cord-259603-bh198xgl	276	33	of	of	IN
cord-259603-bh198xgl	276	34	processive	processive	NNP
cord-259603-bh198xgl	276	35	CoV	CoV	NNP
cord-259603-bh198xgl	276	36	RNA	RNA	NNP
cord-259603-bh198xgl	276	37	synthesis	synthesis	NN
cord-259603-bh198xgl	276	38	(	(	-LRB-
cord-259603-bh198xgl	276	39	see	see	VB
cord-259603-bh198xgl	276	40	later	later	RB
cord-259603-bh198xgl	276	41	)	)	-RRB-
cord-259603-bh198xgl	276	42	.	.	.
cord-259603-bh198xgl	277	1	Using	use	VBG
cord-259603-bh198xgl	277	2	recombinant	recombinant	JJ
cord-259603-bh198xgl	277	3	SARS	SARS	NNP
cord-259603-bh198xgl	277	4	-	-	HYPH
cord-259603-bh198xgl	277	5	CoV	CoV	NNP
cord-259603-bh198xgl	277	6	nsp12	nsp12	NNP
cord-259603-bh198xgl	277	7	,	,	,
cord-259603-bh198xgl	277	8	preliminary	preliminary	JJ
cord-259603-bh198xgl	277	9	evidence	evidence	NN
cord-259603-bh198xgl	277	10	for	for	IN
cord-259603-bh198xgl	277	11	primer	primer	NN
cord-259603-bh198xgl	277	12	-	-	HYPH
cord-259603-bh198xgl	277	13	dependent	dependent	JJ
cord-259603-bh198xgl	277	14	RdRp	RdRp	NNP
cord-259603-bh198xgl	277	15	activity	activity	NN
cord-259603-bh198xgl	277	16	on	on	IN
cord-259603-bh198xgl	277	17	poly(A	poly(A	NNP
cord-259603-bh198xgl	277	18	)	)	-RRB-
cord-259603-bh198xgl	278	1	templates	template	NNS
cord-259603-bh198xgl	278	2	was	be	VBD
cord-259603-bh198xgl	278	3	first	first	RB
cord-259603-bh198xgl	278	4	obtained	obtain	VBN
cord-259603-bh198xgl	278	5	using	use	VBG
cord-259603-bh198xgl	278	6	a	a	DT
cord-259603-bh198xgl	278	7	GST	GST	NNP
cord-259603-bh198xgl	278	8	-	-	HYPH
cord-259603-bh198xgl	278	9	nsp12	nsp12	CD
cord-259603-bh198xgl	278	10	fusion	fusion	NN
cord-259603-bh198xgl	278	11	protein	protein	NN
cord-259603-bh198xgl	278	12	,	,	,
cord-259603-bh198xgl	278	13	although	although	IN
cord-259603-bh198xgl	278	14	these	these	DT
cord-259603-bh198xgl	278	15	efforts	effort	NNS
cord-259603-bh198xgl	278	16	were	be	VBD
cord-259603-bh198xgl	278	17	hampered	hamper	VBN
cord-259603-bh198xgl	278	18	by	by	IN
cord-259603-bh198xgl	278	19	protein	protein	NN
cord-259603-bh198xgl	278	20	instability	instability	NN
cord-259603-bh198xgl	278	21	,	,	,
cord-259603-bh198xgl	278	22	which	which	WDT
cord-259603-bh198xgl	278	23	also	also	RB
cord-259603-bh198xgl	278	24	led	lead	VBD
cord-259603-bh198xgl	278	25	to	to	IN
cord-259603-bh198xgl	278	26	the	the	DT
cord-259603-bh198xgl	278	27	conclusion	conclusion	NN
cord-259603-bh198xgl	278	28	that	that	IN
cord-259603-bh198xgl	278	29	the	the	DT
cord-259603-bh198xgl	278	30	N	n	CD
cord-259603-bh198xgl	278	31	-	-	HYPH
cord-259603-bh198xgl	278	32	terminal	terminal	NN
cord-259603-bh198xgl	278	33	domain	domain	NN
cord-259603-bh198xgl	278	34	of	of	IN
cord-259603-bh198xgl	278	35	nsp12	nsp12	CD
cord-259603-bh198xgl	278	36	is	be	VBZ
cord-259603-bh198xgl	278	37	required	require	VBN
cord-259603-bh198xgl	278	38	for	for	IN
cord-259603-bh198xgl	278	39	activity	activity	NN
cord-259603-bh198xgl	278	40	(	(	-LRB-
cord-259603-bh198xgl	278	41	Cheng	Cheng	NNP
cord-259603-bh198xgl	278	42	et	et	NNP
cord-259603-bh198xgl	278	43	al	al	NNP
cord-259603-bh198xgl	278	44	.	.	NNP
cord-259603-bh198xgl	278	45	,	,	,
cord-259603-bh198xgl	278	46	2005	2005	CD
cord-259603-bh198xgl	278	47	)	)	-RRB-
cord-259603-bh198xgl	278	48	.	.	.
cord-259603-bh198xgl	279	1	Subsequently	subsequently	RB
cord-259603-bh198xgl	279	2	,	,	,
cord-259603-bh198xgl	279	3	a	a	DT
cord-259603-bh198xgl	279	4	C	c	NN
cord-259603-bh198xgl	279	5	-	-	HYPH
cord-259603-bh198xgl	279	6	terminally	terminally	RB
cord-259603-bh198xgl	279	7	His	-PRON-	PRP$
cord-259603-bh198xgl	279	8	6	6	CD
cord-259603-bh198xgl	279	9	-tagged	-tagged	CD
cord-259603-bh198xgl	279	10	SARS	SARS	NNP
cord-259603-bh198xgl	279	11	-	-	HYPH
cord-259603-bh198xgl	279	12	CoV	CoV	NNP
cord-259603-bh198xgl	279	13	nsp12	nsp12	NNP
cord-259603-bh198xgl	279	14	was	be	VBD
cord-259603-bh198xgl	279	15	found	find	VBN
cord-259603-bh198xgl	279	16	to	to	TO
cord-259603-bh198xgl	279	17	mediate	mediate	VB
cord-259603-bh198xgl	279	18	homopolymeric	homopolymeric	NNP
cord-259603-bh198xgl	279	19	RNA	RNA	NNP
cord-259603-bh198xgl	279	20	synthesis	synthesis	NN
cord-259603-bh198xgl	279	21	in	in	IN
cord-259603-bh198xgl	279	22	a	a	DT
cord-259603-bh198xgl	279	23	primer	primer	NN
cord-259603-bh198xgl	279	24	-	-	HYPH
cord-259603-bh198xgl	279	25	dependent	dependent	JJ
cord-259603-bh198xgl	279	26	manner	manner	NN
cord-259603-bh198xgl	280	1	(	(	-LRB-
cord-259603-bh198xgl	280	2	te	te	NNP
cord-259603-bh198xgl	280	3	Velthuis	Velthuis	NNP
cord-259603-bh198xgl	280	4	et	et	NNP
cord-259603-bh198xgl	280	5	al	al	NNP
cord-259603-bh198xgl	280	6	.	.	NNP
cord-259603-bh198xgl	280	7	,	,	,
cord-259603-bh198xgl	280	8	2010	2010	CD
cord-259603-bh198xgl	280	9	)	)	-RRB-
cord-259603-bh198xgl	280	10	.	.	.
cord-259603-bh198xgl	281	1	Both	both	CC
cord-259603-bh198xgl	281	2	these	these	DT
cord-259603-bh198xgl	281	3	activities	activity	NNS
cord-259603-bh198xgl	281	4	must	must	MD
cord-259603-bh198xgl	281	5	probably	probably	RB
cord-259603-bh198xgl	281	6	be	be	VB
cord-259603-bh198xgl	281	7	considered	consider	VBN
cord-259603-bh198xgl	281	8	relatively	relatively	RB
cord-259603-bh198xgl	281	9	weak	weak	JJ
cord-259603-bh198xgl	281	10	and	and	CC
cord-259603-bh198xgl	281	11	nonprocessive	nonprocessive	JJ
cord-259603-bh198xgl	281	12	compared	compare	VBN
cord-259603-bh198xgl	281	13	to	to	IN
cord-259603-bh198xgl	281	14	the	the	DT
cord-259603-bh198xgl	281	15	activity	activity	NN
cord-259603-bh198xgl	281	16	observed	observe	VBD
cord-259603-bh198xgl	281	17	when	when	WRB
cord-259603-bh198xgl	281	18	a	a	DT
cord-259603-bh198xgl	281	19	SARS	SARS	NNP
cord-259603-bh198xgl	281	20	-	-	HYPH
cord-259603-bh198xgl	281	21	CoV	CoV	NNP
cord-259603-bh198xgl	281	22	nsp12	nsp12	NNP
cord-259603-bh198xgl	281	23	RdRp	RdRp	NNP
cord-259603-bh198xgl	281	24	assay	assay	NN
cord-259603-bh198xgl	281	25	was	be	VBD
cord-259603-bh198xgl	281	26	supplemented	supplement	VBN
cord-259603-bh198xgl	281	27	with	with	IN
cord-259603-bh198xgl	281	28	nsp7	nsp7	NN
cord-259603-bh198xgl	281	29	and	and	CC
cord-259603-bh198xgl	281	30	nsp8	nsp8	NN
cord-259603-bh198xgl	281	31	(	(	-LRB-
cord-259603-bh198xgl	281	32	Subissi	Subissi	NNP
cord-259603-bh198xgl	281	33	et	et	NNP
cord-259603-bh198xgl	281	34	al	al	NNP
cord-259603-bh198xgl	281	35	.	.	NNP
cord-259603-bh198xgl	281	36	,	,	,
cord-259603-bh198xgl	281	37	2014b	2014b	CD
cord-259603-bh198xgl	281	38	)	)	-RRB-
cord-259603-bh198xgl	281	39	.	.	.
cord-259603-bh198xgl	282	1	However	however	RB
cord-259603-bh198xgl	282	2	,	,	,
cord-259603-bh198xgl	282	3	at	at	IN
cord-259603-bh198xgl	282	4	the	the	DT
cord-259603-bh198xgl	282	5	same	same	JJ
cord-259603-bh198xgl	282	6	time	time	NN
cord-259603-bh198xgl	282	7	,	,	,
cord-259603-bh198xgl	282	8	this	this	DT
cord-259603-bh198xgl	282	9	study	study	NN
cord-259603-bh198xgl	282	10	reinvigorated	reinvigorate	VBD
cord-259603-bh198xgl	282	11	the	the	DT
cord-259603-bh198xgl	282	12	debate	debate	NN
cord-259603-bh198xgl	282	13	on	on	IN
cord-259603-bh198xgl	282	14	the	the	DT
cord-259603-bh198xgl	282	15	initiation	initiation	NN
cord-259603-bh198xgl	282	16	mechanism	mechanism	NN
cord-259603-bh198xgl	282	17	of	of	IN
cord-259603-bh198xgl	282	18	the	the	DT
cord-259603-bh198xgl	282	19	coronavirus	coronavirus	NN
cord-259603-bh198xgl	282	20	RdRp	RdRp	NNP
cord-259603-bh198xgl	282	21	,	,	,
cord-259603-bh198xgl	282	22	as	as	IN
cord-259603-bh198xgl	282	23	the	the	DT
cord-259603-bh198xgl	282	24	nsp7	nsp7	JJ
cord-259603-bh198xgl	282	25	-	-	HYPH
cord-259603-bh198xgl	282	26	8	8	CD
cord-259603-bh198xgl	282	27	-	-	SYM
cord-259603-bh198xgl	282	28	12	12	CD
cord-259603-bh198xgl	282	29	tripartite	tripartite	JJ
cord-259603-bh198xgl	282	30	complex	complex	NN
cord-259603-bh198xgl	282	31	displayed	display	VBD
cord-259603-bh198xgl	282	32	both	both	CC
cord-259603-bh198xgl	282	33	primer	primer	NN
cord-259603-bh198xgl	282	34	-	-	HYPH
cord-259603-bh198xgl	282	35	dependent	dependent	JJ
cord-259603-bh198xgl	282	36	and	and	CC
cord-259603-bh198xgl	282	37	de	de	FW
cord-259603-bh198xgl	282	38	novo	novo	NNP
cord-259603-bh198xgl	282	39	initiation	initiation	NN
cord-259603-bh198xgl	282	40	of	of	IN
cord-259603-bh198xgl	282	41	RNA	RNA	NNP
cord-259603-bh198xgl	282	42	synthesis	synthesis	NN
cord-259603-bh198xgl	282	43	,	,	,
cord-259603-bh198xgl	282	44	whereas	whereas	IN
cord-259603-bh198xgl	282	45	no	no	DT
cord-259603-bh198xgl	282	46	de	de	FW
cord-259603-bh198xgl	282	47	novo	novo	NN
cord-259603-bh198xgl	282	48	-	-	HYPH
cord-259603-bh198xgl	282	49	initiating	initiate	VBG
cord-259603-bh198xgl	282	50	RdRp	RdRp	NNP
cord-259603-bh198xgl	282	51	activity	activity	NN
cord-259603-bh198xgl	282	52	could	could	MD
cord-259603-bh198xgl	282	53	be	be	VB
cord-259603-bh198xgl	282	54	detected	detect	VBN
cord-259603-bh198xgl	282	55	for	for	IN
cord-259603-bh198xgl	282	56	nsp8	nsp8	NN
cord-259603-bh198xgl	282	57	or	or	CC
cord-259603-bh198xgl	282	58	the	the	DT
cord-259603-bh198xgl	282	59	nsp7-nsp8	nsp7-nsp8	NNP
cord-259603-bh198xgl	282	60	complex	complex	NN
cord-259603-bh198xgl	282	61	alone	alone	RB
cord-259603-bh198xgl	283	1	(	(	-LRB-
cord-259603-bh198xgl	283	2	Subissi	Subissi	NNP
cord-259603-bh198xgl	283	3	et	et	NNP
cord-259603-bh198xgl	283	4	al	al	NNP
cord-259603-bh198xgl	283	5	.	.	NNP
cord-259603-bh198xgl	283	6	,	,	,
cord-259603-bh198xgl	283	7	2014b	2014b	CD
cord-259603-bh198xgl	283	8	)	)	-RRB-
cord-259603-bh198xgl	283	9	.	.	.
cord-259603-bh198xgl	284	1	To	to	TO
cord-259603-bh198xgl	284	2	add	add	VB
cord-259603-bh198xgl	284	3	to	to	IN
cord-259603-bh198xgl	284	4	the	the	DT
cord-259603-bh198xgl	284	5	confusion	confusion	NN
cord-259603-bh198xgl	284	6	,	,	,
cord-259603-bh198xgl	284	7	other	other	JJ
cord-259603-bh198xgl	284	8	studies	study	NNS
cord-259603-bh198xgl	284	9	reported	report	VBD
cord-259603-bh198xgl	284	10	de	de	IN
cord-259603-bh198xgl	284	11	novo	novo	NNP
cord-259603-bh198xgl	284	12	initiation	initiation	NN
cord-259603-bh198xgl	284	13	by	by	IN
cord-259603-bh198xgl	284	14	SARS	SARS	NNP
cord-259603-bh198xgl	284	15	-	-	HYPH
cord-259603-bh198xgl	284	16	CoV	CoV	NNP
cord-259603-bh198xgl	284	17	nsp12	nsp12	NNS
cord-259603-bh198xgl	284	18	alone	alone	JJ
cord-259603-bh198xgl	285	1	(	(	-LRB-
cord-259603-bh198xgl	285	2	Ahn	Ahn	NNP
cord-259603-bh198xgl	285	3	et	et	NNP
cord-259603-bh198xgl	285	4	al	al	NNP
cord-259603-bh198xgl	285	5	.	.	NNP
cord-259603-bh198xgl	285	6	,	,	,
cord-259603-bh198xgl	285	7	2012	2012	CD
cord-259603-bh198xgl	285	8	)	)	-RRB-
cord-259603-bh198xgl	285	9	and	and	CC
cord-259603-bh198xgl	285	10	primer	primer	NN
cord-259603-bh198xgl	285	11	-	-	HYPH
cord-259603-bh198xgl	285	12	dependent	dependent	JJ
cord-259603-bh198xgl	285	13	RdRp	RdRp	NNP
cord-259603-bh198xgl	285	14	activity	activity	NN
cord-259603-bh198xgl	285	15	of	of	IN
cord-259603-bh198xgl	285	16	SARS	SARS	NNP
cord-259603-bh198xgl	285	17	-	-	HYPH
cord-259603-bh198xgl	285	18	CoV	CoV	NNP
cord-259603-bh198xgl	285	19	nsp8	nsp8	NN
cord-259603-bh198xgl	285	20	,	,	,
cord-259603-bh198xgl	285	21	when	when	WRB
cord-259603-bh198xgl	285	22	expressed	express	VBN
cord-259603-bh198xgl	285	23	without	without	IN
cord-259603-bh198xgl	285	24	affinity	affinity	NN
cord-259603-bh198xgl	285	25	tags	tag	NNS
cord-259603-bh198xgl	285	26	commonly	commonly	RB
cord-259603-bh198xgl	285	27	used	use	VBN
cord-259603-bh198xgl	285	28	to	to	TO
cord-259603-bh198xgl	285	29	facilitate	facilitate	VB
cord-259603-bh198xgl	285	30	purification	purification	NN
cord-259603-bh198xgl	285	31	(	(	-LRB-
cord-259603-bh198xgl	285	32	te	te	NNP
cord-259603-bh198xgl	285	33	Velthuis	Velthuis	NNP
cord-259603-bh198xgl	285	34	et	et	NNP
cord-259603-bh198xgl	285	35	al	al	NNP
cord-259603-bh198xgl	285	36	.	.	NNP
cord-259603-bh198xgl	285	37	,	,	,
cord-259603-bh198xgl	285	38	2012	2012	CD
cord-259603-bh198xgl	285	39	)	)	-RRB-
cord-259603-bh198xgl	285	40	.	.	.
cord-259603-bh198xgl	286	1	Technical	technical	JJ
cord-259603-bh198xgl	286	2	differences	difference	NNS
cord-259603-bh198xgl	286	3	between	between	IN
cord-259603-bh198xgl	286	4	these	these	DT
cord-259603-bh198xgl	286	5	studies	study	NNS
cord-259603-bh198xgl	286	6	and	and	CC
cord-259603-bh198xgl	286	7	those	those	DT
cord-259603-bh198xgl	286	8	summarized	summarize	VBN
cord-259603-bh198xgl	286	9	earlier	early	RBR
cord-259603-bh198xgl	286	10	(	(	-LRB-
cord-259603-bh198xgl	286	11	e.g.	e.g.	RB
cord-259603-bh198xgl	286	12	,	,	,
cord-259603-bh198xgl	286	13	regarding	regard	VBG
cord-259603-bh198xgl	286	14	expression	expression	NN
cord-259603-bh198xgl	286	15	constructs	construct	NNS
cord-259603-bh198xgl	286	16	and	and	CC
cord-259603-bh198xgl	286	17	templates	template	NNS
cord-259603-bh198xgl	286	18	used	use	VBN
cord-259603-bh198xgl	286	19	)	)	-RRB-
cord-259603-bh198xgl	286	20	may	may	MD
cord-259603-bh198xgl	286	21	have	have	VB
cord-259603-bh198xgl	286	22	contributed	contribute	VBN
cord-259603-bh198xgl	286	23	to	to	IN
cord-259603-bh198xgl	286	24	the	the	DT
cord-259603-bh198xgl	286	25	contradictory	contradictory	JJ
cord-259603-bh198xgl	286	26	results	result	NNS
cord-259603-bh198xgl	286	27	obtained	obtain	VBN
cord-259603-bh198xgl	286	28	on	on	IN
cord-259603-bh198xgl	286	29	the	the	DT
cord-259603-bh198xgl	286	30	RdRp	RdRp	NNP
cord-259603-bh198xgl	286	31	activities	activity	NNS
cord-259603-bh198xgl	286	32	of	of	IN
cord-259603-bh198xgl	286	33	nsp8	nsp8	NN
cord-259603-bh198xgl	286	34	and	and	CC
cord-259603-bh198xgl	286	35	nsp12	nsp12	CD
cord-259603-bh198xgl	286	36	.	.	.
cord-259603-bh198xgl	287	1	Thus	thus	RB
cord-259603-bh198xgl	287	2	far	far	RB
cord-259603-bh198xgl	287	3	,	,	,
cord-259603-bh198xgl	287	4	five	five	CD
cord-259603-bh198xgl	287	5	different	different	JJ
cord-259603-bh198xgl	287	6	laboratories	laboratory	NNS
cord-259603-bh198xgl	287	7	addressed	address	VBD
cord-259603-bh198xgl	287	8	the	the	DT
cord-259603-bh198xgl	287	9	two	two	CD
cord-259603-bh198xgl	287	10	(	(	-LRB-
cord-259603-bh198xgl	287	11	putative	putative	JJ
cord-259603-bh198xgl	287	12	)	)	-RRB-
cord-259603-bh198xgl	287	13	coronavirus	coronavirus	NN
cord-259603-bh198xgl	287	14	RdRps	RdRps	NNP
cord-259603-bh198xgl	287	15	in	in	IN
cord-259603-bh198xgl	287	16	seven	seven	CD
cord-259603-bh198xgl	287	17	independent	independent	JJ
cord-259603-bh198xgl	287	18	studies	study	NNS
cord-259603-bh198xgl	287	19	,	,	,
cord-259603-bh198xgl	287	20	none	none	NN
cord-259603-bh198xgl	287	21	of	of	IN
cord-259603-bh198xgl	287	22	which	which	WDT
cord-259603-bh198xgl	287	23	succeeded	succeed	VBD
cord-259603-bh198xgl	287	24	in	in	IN
cord-259603-bh198xgl	287	25	exactly	exactly	RB
cord-259603-bh198xgl	287	26	reproducing	reproduce	VBG
cord-259603-bh198xgl	287	27	the	the	DT
cord-259603-bh198xgl	287	28	results	result	NNS
cord-259603-bh198xgl	287	29	of	of	IN
cord-259603-bh198xgl	287	30	any	any	DT
cord-259603-bh198xgl	287	31	of	of	IN
cord-259603-bh198xgl	287	32	the	the	DT
cord-259603-bh198xgl	287	33	other	other	JJ
cord-259603-bh198xgl	287	34	studies	study	NNS
cord-259603-bh198xgl	287	35	(	(	-LRB-
cord-259603-bh198xgl	287	36	Ahn	Ahn	NNP
cord-259603-bh198xgl	287	37	et	et	NNP
cord-259603-bh198xgl	287	38	al	al	NNP
cord-259603-bh198xgl	287	39	.	.	NNP
cord-259603-bh198xgl	287	40	,	,	,
cord-259603-bh198xgl	287	41	2012	2012	CD
cord-259603-bh198xgl	287	42	;	;	:
cord-259603-bh198xgl	287	43	Cheng	Cheng	NNP
cord-259603-bh198xgl	287	44	et	et	NNP
cord-259603-bh198xgl	287	45	al	al	NNP
cord-259603-bh198xgl	287	46	.	.	NNP
cord-259603-bh198xgl	287	47	,	,	,
cord-259603-bh198xgl	287	48	2005	2005	CD
cord-259603-bh198xgl	287	49	;	;	:
cord-259603-bh198xgl	288	1	Imbert	Imbert	NNP
cord-259603-bh198xgl	288	2	et	et	NNP
cord-259603-bh198xgl	288	3	al	al	NNP
cord-259603-bh198xgl	288	4	.	.	NNP
cord-259603-bh198xgl	288	5	,	,	,
cord-259603-bh198xgl	288	6	2006	2006	CD
cord-259603-bh198xgl	288	7	;	;	:
cord-259603-bh198xgl	288	8	Subissi	Subissi	NNP
cord-259603-bh198xgl	288	9	et	et	NNP
cord-259603-bh198xgl	288	10	al	al	NNP
cord-259603-bh198xgl	288	11	.	.	NNP
cord-259603-bh198xgl	288	12	,	,	,
cord-259603-bh198xgl	288	13	2014b	2014b	CD
cord-259603-bh198xgl	288	14	;	;	:
cord-259603-bh198xgl	288	15	te	te	NNP
cord-259603-bh198xgl	288	16	Velthuis	Velthuis	NNP
cord-259603-bh198xgl	288	17	et	et	NNP
cord-259603-bh198xgl	288	18	al	al	NNP
cord-259603-bh198xgl	288	19	.	.	.
cord-259603-bh198xgl	289	1	,	,	,
cord-259603-bh198xgl	289	2	2010	2010	CD
cord-259603-bh198xgl	290	1	te	te	NNP
cord-259603-bh198xgl	290	2	Velthuis	Velthuis	NNP
cord-259603-bh198xgl	290	3	et	et	NNP
cord-259603-bh198xgl	290	4	al	al	NNP
cord-259603-bh198xgl	290	5	.	.	.
cord-259603-bh198xgl	291	1	,	,	,
cord-259603-bh198xgl	291	2	,	,	,
cord-259603-bh198xgl	291	3	2012	2012	CD
cord-259603-bh198xgl	291	4	Xiao	Xiao	NNP
cord-259603-bh198xgl	291	5	et	et	NNP
cord-259603-bh198xgl	291	6	al	al	NNP
cord-259603-bh198xgl	291	7	.	.	NNP
cord-259603-bh198xgl	291	8	,	,	,
cord-259603-bh198xgl	291	9	2012	2012	CD
cord-259603-bh198xgl	291	10	)	)	-RRB-
cord-259603-bh198xgl	291	11	.	.	.
cord-259603-bh198xgl	292	1	Nidovirus	Nidovirus	NNP
cord-259603-bh198xgl	292	2	RdRps	RdRps	NNP
cord-259603-bh198xgl	292	3	appear	appear	VBP
cord-259603-bh198xgl	292	4	to	to	TO
cord-259603-bh198xgl	292	5	be	be	VB
cord-259603-bh198xgl	292	6	technically	technically	RB
cord-259603-bh198xgl	292	7	challenging	challenging	JJ
cord-259603-bh198xgl	292	8	and	and	CC
cord-259603-bh198xgl	292	9	sensitive	sensitive	JJ
cord-259603-bh198xgl	292	10	proteins	protein	NNS
cord-259603-bh198xgl	292	11	that	that	WDT
cord-259603-bh198xgl	292	12	may	may	MD
cord-259603-bh198xgl	292	13	respond	respond	VB
cord-259603-bh198xgl	292	14	to	to	TO
cord-259603-bh198xgl	292	15	minute	minute	VB
cord-259603-bh198xgl	292	16	changes	change	NNS
cord-259603-bh198xgl	292	17	in	in	IN
cord-259603-bh198xgl	292	18	purification	purification	NN
cord-259603-bh198xgl	292	19	protocols	protocol	NNS
cord-259603-bh198xgl	292	20	or	or	CC
cord-259603-bh198xgl	292	21	assay	assay	NN
cord-259603-bh198xgl	292	22	conditions	condition	NNS
cord-259603-bh198xgl	292	23	.	.	.
cord-259603-bh198xgl	293	1	Clearly	clearly	RB
cord-259603-bh198xgl	293	2	,	,	,
cord-259603-bh198xgl	293	3	both	both	CC
cord-259603-bh198xgl	293	4	the	the	DT
cord-259603-bh198xgl	293	5	role	role	NN
cord-259603-bh198xgl	293	6	of	of	IN
cord-259603-bh198xgl	293	7	nsp8	nsp8	NN
cord-259603-bh198xgl	293	8	(	(	-LRB-
cord-259603-bh198xgl	293	9	primase	primase	NN
cord-259603-bh198xgl	293	10	or	or	CC
cord-259603-bh198xgl	293	11	processivity	processivity	NN
cord-259603-bh198xgl	293	12	factor	factor	NN
cord-259603-bh198xgl	293	13	?	?	.
cord-259603-bh198xgl	293	14	)	)	-RRB-
cord-259603-bh198xgl	293	15	and	and	CC
cord-259603-bh198xgl	293	16	the	the	DT
cord-259603-bh198xgl	293	17	initiation	initiation	NN
cord-259603-bh198xgl	293	18	mechanism	mechanism	NN
cord-259603-bh198xgl	293	19	employed	employ	VBN
cord-259603-bh198xgl	293	20	by	by	IN
cord-259603-bh198xgl	293	21	the	the	DT
cord-259603-bh198xgl	293	22	nsp12-RdRp	nsp12-RdRp	NNS
cord-259603-bh198xgl	293	23	require	require	VBP
cord-259603-bh198xgl	293	24	further	further	JJ
cord-259603-bh198xgl	293	25	study	study	NN
cord-259603-bh198xgl	293	26	.	.	.
cord-259603-bh198xgl	294	1	Although	although	IN
cord-259603-bh198xgl	294	2	the	the	DT
cord-259603-bh198xgl	294	3	bioinformatics	bioinformatics	NN
cord-259603-bh198xgl	294	4	-	-	HYPH
cord-259603-bh198xgl	294	5	based	base	VBN
cord-259603-bh198xgl	294	6	prediction	prediction	NN
cord-259603-bh198xgl	294	7	that	that	IN
cord-259603-bh198xgl	294	8	nsp12	nsp12	CD
cord-259603-bh198xgl	294	9	uses	use	VBZ
cord-259603-bh198xgl	294	10	a	a	DT
cord-259603-bh198xgl	294	11	primer	primer	NN
cord-259603-bh198xgl	294	12	-	-	HYPH
cord-259603-bh198xgl	294	13	dependent	dependent	JJ
cord-259603-bh198xgl	294	14	initiation	initiation	NN
cord-259603-bh198xgl	294	15	mechanism	mechanism	NN
cord-259603-bh198xgl	294	16	is	be	VBZ
cord-259603-bh198xgl	294	17	compelling	compelling	JJ
cord-259603-bh198xgl	294	18	,	,	,
cord-259603-bh198xgl	294	19	it	-PRON-	PRP
cord-259603-bh198xgl	294	20	lacks	lack	VBZ
cord-259603-bh198xgl	294	21	the	the	DT
cord-259603-bh198xgl	294	22	direct	direct	JJ
cord-259603-bh198xgl	294	23	support	support	NN
cord-259603-bh198xgl	294	24	of	of	IN
cord-259603-bh198xgl	294	25	an	an	DT
cord-259603-bh198xgl	294	26	nsp12	nsp12	CD
cord-259603-bh198xgl	294	27	crystal	crystal	NN
cord-259603-bh198xgl	294	28	structure	structure	NN
cord-259603-bh198xgl	294	29	.	.	.
cord-259603-bh198xgl	295	1	At	at	IN
cord-259603-bh198xgl	295	2	the	the	DT
cord-259603-bh198xgl	295	3	same	same	JJ
cord-259603-bh198xgl	295	4	time	time	NN
cord-259603-bh198xgl	295	5	,	,	,
cord-259603-bh198xgl	295	6	the	the	DT
cord-259603-bh198xgl	295	7	question	question	NN
cord-259603-bh198xgl	295	8	of	of	IN
cord-259603-bh198xgl	295	9	the	the	DT
cord-259603-bh198xgl	295	10	nature	nature	NN
cord-259603-bh198xgl	295	11	and	and	CC
cord-259603-bh198xgl	295	12	source	source	NN
cord-259603-bh198xgl	295	13	of	of	IN
cord-259603-bh198xgl	295	14	the	the	DT
cord-259603-bh198xgl	295	15	primer	primer	NN
cord-259603-bh198xgl	295	16	that	that	WDT
cord-259603-bh198xgl	295	17	would	would	MD
cord-259603-bh198xgl	295	18	be	be	VB
cord-259603-bh198xgl	295	19	used	use	VBN
cord-259603-bh198xgl	295	20	by	by	IN
cord-259603-bh198xgl	295	21	nsp12	nsp12	NNP
cord-259603-bh198xgl	295	22	seems	seem	VBZ
cord-259603-bh198xgl	295	23	to	to	TO
cord-259603-bh198xgl	295	24	be	be	VB
cord-259603-bh198xgl	295	25	wide	wide	RB
cord-259603-bh198xgl	295	26	open	open	JJ
cord-259603-bh198xgl	295	27	again	again	RB
cord-259603-bh198xgl	295	28	.	.	.
cord-259603-bh198xgl	296	1	As	as	IN
cord-259603-bh198xgl	296	2	for	for	IN
cord-259603-bh198xgl	296	3	other	other	JJ
cord-259603-bh198xgl	296	4	RNA	RNA	NNP
cord-259603-bh198xgl	296	5	viruses	virus	NNS
cord-259603-bh198xgl	296	6	,	,	,
cord-259603-bh198xgl	296	7	the	the	DT
cord-259603-bh198xgl	296	8	nsp12-RdRp	nsp12-rdrp	NN
cord-259603-bh198xgl	296	9	of	of	IN
cord-259603-bh198xgl	296	10	CoVs	CoVs	NNP
cord-259603-bh198xgl	296	11	is	be	VBZ
cord-259603-bh198xgl	296	12	a	a	DT
cord-259603-bh198xgl	296	13	primary	primary	JJ
cord-259603-bh198xgl	296	14	drug	drug	NN
cord-259603-bh198xgl	296	15	target	target	NN
cord-259603-bh198xgl	296	16	that	that	WDT
cord-259603-bh198xgl	296	17	may	may	MD
cord-259603-bh198xgl	296	18	,	,	,
cord-259603-bh198xgl	296	19	in	in	IN
cord-259603-bh198xgl	296	20	principle	principle	NN
cord-259603-bh198xgl	296	21	,	,	,
cord-259603-bh198xgl	296	22	be	be	VB
cord-259603-bh198xgl	296	23	inhibited	inhibit	VBN
cord-259603-bh198xgl	296	24	without	without	IN
cord-259603-bh198xgl	296	25	major	major	JJ
cord-259603-bh198xgl	296	26	toxic	toxic	JJ
cord-259603-bh198xgl	296	27	side	side	NN
cord-259603-bh198xgl	296	28	effects	effect	NNS
cord-259603-bh198xgl	296	29	for	for	IN
cord-259603-bh198xgl	296	30	the	the	DT
cord-259603-bh198xgl	296	31	host	host	NN
cord-259603-bh198xgl	296	32	cell	cell	NN
cord-259603-bh198xgl	296	33	.	.	.
cord-259603-bh198xgl	297	1	Nucleoside	nucleoside	JJ
cord-259603-bh198xgl	297	2	analogs	analog	NNS
cord-259603-bh198xgl	297	3	constitute	constitute	VBP
cord-259603-bh198xgl	297	4	an	an	DT
cord-259603-bh198xgl	297	5	important	important	JJ
cord-259603-bh198xgl	297	6	class	class	NN
cord-259603-bh198xgl	297	7	of	of	IN
cord-259603-bh198xgl	297	8	antiviral	antiviral	JJ
cord-259603-bh198xgl	297	9	drug	drug	NN
cord-259603-bh198xgl	297	10	candidates	candidate	NNS
cord-259603-bh198xgl	297	11	that	that	WDT
cord-259603-bh198xgl	297	12	can	can	MD
cord-259603-bh198xgl	297	13	target	target	VB
cord-259603-bh198xgl	297	14	viral	viral	JJ
cord-259603-bh198xgl	297	15	RdRps	RdRps	NNP
cord-259603-bh198xgl	297	16	,	,	,
cord-259603-bh198xgl	297	17	but	but	CC
cord-259603-bh198xgl	297	18	efforts	effort	NNS
cord-259603-bh198xgl	297	19	to	to	TO
cord-259603-bh198xgl	297	20	use	use	VB
cord-259603-bh198xgl	297	21	them	-PRON-	PRP
cord-259603-bh198xgl	297	22	to	to	TO
cord-259603-bh198xgl	297	23	inhibit	inhibit	VB
cord-259603-bh198xgl	297	24	CoV	cov	NN
cord-259603-bh198xgl	297	25	replication	replication	NN
cord-259603-bh198xgl	297	26	were	be	VBD
cord-259603-bh198xgl	297	27	not	not	RB
cord-259603-bh198xgl	297	28	very	very	RB
cord-259603-bh198xgl	297	29	successful	successful	JJ
cord-259603-bh198xgl	297	30	thus	thus	RB
cord-259603-bh198xgl	297	31	far	far	RB
cord-259603-bh198xgl	298	1	(	(	-LRB-
cord-259603-bh198xgl	298	2	Chu	Chu	NNP
cord-259603-bh198xgl	298	3	et	et	FW
cord-259603-bh198xgl	298	4	al	al	NNP
cord-259603-bh198xgl	298	5	.	.	NNP
cord-259603-bh198xgl	298	6	,	,	,
cord-259603-bh198xgl	298	7	2006	2006	CD
cord-259603-bh198xgl	299	1	;	;	:
cord-259603-bh198xgl	299	2	Ikejiri	Ikejiri	NNP
cord-259603-bh198xgl	299	3	et	et	NNP
cord-259603-bh198xgl	299	4	al	al	NNP
cord-259603-bh198xgl	299	5	.	.	NNP
cord-259603-bh198xgl	299	6	,	,	,
cord-259603-bh198xgl	299	7	2007	2007	CD
cord-259603-bh198xgl	299	8	)	)	-RRB-
cord-259603-bh198xgl	299	9	.	.	.
cord-259603-bh198xgl	300	1	Moreover	moreover	RB
cord-259603-bh198xgl	300	2	,	,	,
cord-259603-bh198xgl	300	3	it	-PRON-	PRP
cord-259603-bh198xgl	300	4	remains	remain	VBZ
cord-259603-bh198xgl	300	5	to	to	TO
cord-259603-bh198xgl	300	6	be	be	VB
cord-259603-bh198xgl	300	7	established	establish	VBN
cord-259603-bh198xgl	300	8	that	that	IN
cord-259603-bh198xgl	300	9	their	-PRON-	PRP$
cord-259603-bh198xgl	300	10	target	target	NN
cord-259603-bh198xgl	300	11	in	in	IN
cord-259603-bh198xgl	300	12	the	the	DT
cord-259603-bh198xgl	300	13	infected	infected	JJ
cord-259603-bh198xgl	300	14	cell	cell	NN
cord-259603-bh198xgl	300	15	is	be	VBZ
cord-259603-bh198xgl	300	16	indeed	indeed	RB
cord-259603-bh198xgl	300	17	the	the	DT
cord-259603-bh198xgl	300	18	nsp12-RdRp	nsp12-rdrp	NN
cord-259603-bh198xgl	300	19	.	.	.
cord-259603-bh198xgl	301	1	The	the	DT
cord-259603-bh198xgl	301	2	mismatch	mismatch	NN
cord-259603-bh198xgl	301	3	repair	repair	NN
cord-259603-bh198xgl	301	4	capabilities	capability	NNS
cord-259603-bh198xgl	301	5	attributed	attribute	VBN
cord-259603-bh198xgl	301	6	to	to	IN
cord-259603-bh198xgl	301	7	the	the	DT
cord-259603-bh198xgl	301	8	nsp14-ExoN	nsp14-ExoN	NNP
cord-259603-bh198xgl	301	9	domain	domain	NN
cord-259603-bh198xgl	301	10	(	(	-LRB-
cord-259603-bh198xgl	301	11	see	see	VB
cord-259603-bh198xgl	301	12	later	later	RB
cord-259603-bh198xgl	301	13	)	)	-RRB-
cord-259603-bh198xgl	302	1	(	(	-LRB-
cord-259603-bh198xgl	302	2	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	302	3	et	et	NNP
cord-259603-bh198xgl	302	4	al	al	NNP
cord-259603-bh198xgl	302	5	.	.	NNP
cord-259603-bh198xgl	302	6	,	,	,
cord-259603-bh198xgl	302	7	2012	2012	CD
cord-259603-bh198xgl	302	8	)	)	-RRB-
cord-259603-bh198xgl	302	9	may	may	MD
cord-259603-bh198xgl	302	10	pose	pose	VB
cord-259603-bh198xgl	302	11	an	an	DT
cord-259603-bh198xgl	302	12	additional	additional	JJ
cord-259603-bh198xgl	302	13	hurdle	hurdle	NN
cord-259603-bh198xgl	302	14	,	,	,
cord-259603-bh198xgl	302	15	as	as	IN
cord-259603-bh198xgl	302	16	the	the	DT
cord-259603-bh198xgl	302	17	efficacy	efficacy	NN
cord-259603-bh198xgl	302	18	of	of	IN
cord-259603-bh198xgl	302	19	a	a	DT
cord-259603-bh198xgl	302	20	nucleoside	nucleoside	NN
cord-259603-bh198xgl	302	21	analogue	analogue	NN
cord-259603-bh198xgl	302	22	with	with	IN
cord-259603-bh198xgl	302	23	anticoronavirus	anticoronavirus	NN
cord-259603-bh198xgl	302	24	activity	activity	NN
cord-259603-bh198xgl	302	25	may	may	MD
cord-259603-bh198xgl	302	26	be	be	VB
cord-259603-bh198xgl	302	27	determined	determine	VBN
cord-259603-bh198xgl	302	28	by	by	IN
cord-259603-bh198xgl	302	29	the	the	DT
cord-259603-bh198xgl	302	30	balance	balance	NN
cord-259603-bh198xgl	302	31	between	between	IN
cord-259603-bh198xgl	302	32	its	-PRON-	PRP$
cord-259603-bh198xgl	302	33	propensity	propensity	NN
cord-259603-bh198xgl	302	34	to	to	TO
cord-259603-bh198xgl	302	35	be	be	VB
cord-259603-bh198xgl	302	36	incorporated	incorporate	VBN
cord-259603-bh198xgl	302	37	by	by	IN
cord-259603-bh198xgl	302	38	the	the	DT
cord-259603-bh198xgl	302	39	nsp12-RdRp	nsp12-rdrp	NN
cord-259603-bh198xgl	302	40	and	and	CC
cord-259603-bh198xgl	302	41	its	-PRON-	PRP$
cord-259603-bh198xgl	302	42	tendency	tendency	NN
cord-259603-bh198xgl	302	43	to	to	TO
cord-259603-bh198xgl	302	44	resist	resist	VB
cord-259603-bh198xgl	302	45	excision	excision	NN
cord-259603-bh198xgl	302	46	by	by	IN
cord-259603-bh198xgl	302	47	the	the	DT
cord-259603-bh198xgl	302	48	mismatch	mismatch	NN
cord-259603-bh198xgl	302	49	repair	repair	NN
cord-259603-bh198xgl	302	50	mechanism	mechanism	NN
cord-259603-bh198xgl	302	51	mediated	mediate	VBN
cord-259603-bh198xgl	302	52	by	by	IN
cord-259603-bh198xgl	302	53	nsp14-ExoN.	nsp14-exon.	NN
cord-259603-bh198xgl	303	1	Similar	similar	JJ
cord-259603-bh198xgl	303	2	considerations	consideration	NNS
cord-259603-bh198xgl	303	3	apply	apply	VBP
cord-259603-bh198xgl	303	4	to	to	IN
cord-259603-bh198xgl	303	5	ribavirin	ribavirin	NN
cord-259603-bh198xgl	303	6	,	,	,
cord-259603-bh198xgl	303	7	a	a	DT
cord-259603-bh198xgl	303	8	guanosine	guanosine	NN
cord-259603-bh198xgl	303	9	analog	analog	NN
cord-259603-bh198xgl	303	10	with	with	IN
cord-259603-bh198xgl	303	11	broadspectrum	broadspectrum	NNP
cord-259603-bh198xgl	303	12	antiviral	antiviral	JJ
cord-259603-bh198xgl	303	13	activity	activity	NN
cord-259603-bh198xgl	303	14	that	that	WDT
cord-259603-bh198xgl	303	15	is	be	VBZ
cord-259603-bh198xgl	303	16	used	use	VBN
cord-259603-bh198xgl	303	17	to	to	TO
cord-259603-bh198xgl	303	18	treat	treat	VB
cord-259603-bh198xgl	303	19	patients	patient	NNS
cord-259603-bh198xgl	303	20	infected	infect	VBN
cord-259603-bh198xgl	303	21	with	with	IN
cord-259603-bh198xgl	303	22	a	a	DT
cord-259603-bh198xgl	303	23	variety	variety	NN
cord-259603-bh198xgl	303	24	of	of	IN
cord-259603-bh198xgl	303	25	RNA	RNA	NNP
cord-259603-bh198xgl	303	26	viruses	virus	NNS
cord-259603-bh198xgl	303	27	.	.	.
cord-259603-bh198xgl	304	1	Its	-PRON-	PRP$
cord-259603-bh198xgl	304	2	mechanism	mechanism	NN
cord-259603-bh198xgl	304	3	of	of	IN
cord-259603-bh198xgl	304	4	action	action	NN
cord-259603-bh198xgl	304	5	appears	appear	VBZ
cord-259603-bh198xgl	304	6	to	to	TO
cord-259603-bh198xgl	304	7	differ	differ	VB
cord-259603-bh198xgl	304	8	on	on	IN
cord-259603-bh198xgl	304	9	a	a	DT
cord-259603-bh198xgl	304	10	case	case	NN
cord-259603-bh198xgl	304	11	-	-	HYPH
cord-259603-bh198xgl	304	12	by	by	IN
cord-259603-bh198xgl	304	13	-	-	HYPH
cord-259603-bh198xgl	304	14	case	case	NN
cord-259603-bh198xgl	304	15	basis	basis	NN
cord-259603-bh198xgl	304	16	,	,	,
cord-259603-bh198xgl	304	17	but	but	CC
cord-259603-bh198xgl	304	18	may	may	MD
cord-259603-bh198xgl	304	19	include	include	VB
cord-259603-bh198xgl	304	20	the	the	DT
cord-259603-bh198xgl	304	21	induction	induction	NN
cord-259603-bh198xgl	304	22	of	of	IN
cord-259603-bh198xgl	304	23	lethal	lethal	JJ
cord-259603-bh198xgl	304	24	mutagenesis	mutagenesis	NN
cord-259603-bh198xgl	304	25	by	by	IN
cord-259603-bh198xgl	304	26	increasing	increase	VBG
cord-259603-bh198xgl	304	27	the	the	DT
cord-259603-bh198xgl	304	28	RdRp	RdRp	NNP
cord-259603-bh198xgl	304	29	error	error	NN
cord-259603-bh198xgl	304	30	rate	rate	NN
cord-259603-bh198xgl	304	31	,	,	,
cord-259603-bh198xgl	304	32	inhibition	inhibition	NN
cord-259603-bh198xgl	304	33	of	of	IN
cord-259603-bh198xgl	304	34	viral	viral	JJ
cord-259603-bh198xgl	304	35	mRNA	mrna	NN
cord-259603-bh198xgl	304	36	capping	capping	NN
cord-259603-bh198xgl	304	37	,	,	,
cord-259603-bh198xgl	304	38	and	and	CC
cord-259603-bh198xgl	304	39	reduction	reduction	NN
cord-259603-bh198xgl	304	40	of	of	IN
cord-259603-bh198xgl	304	41	viral	viral	JJ
cord-259603-bh198xgl	304	42	RNA	RNA	NNP
cord-259603-bh198xgl	304	43	synthesis	synthesis	NN
cord-259603-bh198xgl	304	44	by	by	IN
cord-259603-bh198xgl	304	45	inhibition	inhibition	NN
cord-259603-bh198xgl	304	46	of	of	IN
cord-259603-bh198xgl	304	47	the	the	DT
cord-259603-bh198xgl	304	48	cellular	cellular	JJ
cord-259603-bh198xgl	304	49	enzyme	enzyme	NN
cord-259603-bh198xgl	305	1	inosine	inosine	NNP
cord-259603-bh198xgl	305	2	monophosphate	monophosphate	NN
cord-259603-bh198xgl	305	3	dehydrogenase	dehydrogenase	NN
cord-259603-bh198xgl	305	4	(	(	-LRB-
cord-259603-bh198xgl	305	5	IMPDH	IMPDH	NNP
cord-259603-bh198xgl	305	6	)	)	-RRB-
cord-259603-bh198xgl	305	7	,	,	,
cord-259603-bh198xgl	305	8	which	which	WDT
cord-259603-bh198xgl	305	9	decreases	decrease	VBZ
cord-259603-bh198xgl	305	10	the	the	DT
cord-259603-bh198xgl	305	11	availability	availability	NN
cord-259603-bh198xgl	305	12	of	of	IN
cord-259603-bh198xgl	305	13	intracellular	intracellular	JJ
cord-259603-bh198xgl	305	14	GTP	GTP	NNP
cord-259603-bh198xgl	305	15	(	(	-LRB-
cord-259603-bh198xgl	305	16	Crotty	Crotty	NNP
cord-259603-bh198xgl	305	17	et	et	NNP
cord-259603-bh198xgl	305	18	al	al	NNP
cord-259603-bh198xgl	305	19	.	.	NNP
cord-259603-bh198xgl	305	20	,	,	,
cord-259603-bh198xgl	305	21	2000	2000	CD
cord-259603-bh198xgl	305	22	(	(	-LRB-
cord-259603-bh198xgl	305	23	Crotty	Crotty	NNP
cord-259603-bh198xgl	305	24	et	et	NNP
cord-259603-bh198xgl	305	25	al	al	NNP
cord-259603-bh198xgl	305	26	.	.	NNP
cord-259603-bh198xgl	305	27	,	,	,
cord-259603-bh198xgl	305	28	,	,	,
cord-259603-bh198xgl	305	29	2002	2002	CD
cord-259603-bh198xgl	305	30	Smith	Smith	NNP
cord-259603-bh198xgl	305	31	et	et	NNP
cord-259603-bh198xgl	305	32	al	al	NNP
cord-259603-bh198xgl	305	33	.	.	NNP
cord-259603-bh198xgl	305	34	,	,	,
cord-259603-bh198xgl	305	35	2013	2013	CD
cord-259603-bh198xgl	306	1	Smith	Smith	NNP
cord-259603-bh198xgl	306	2	et	et	NNP
cord-259603-bh198xgl	306	3	al	al	NNP
cord-259603-bh198xgl	306	4	.	.	.
cord-259603-bh198xgl	307	1	,	,	,
cord-259603-bh198xgl	307	2	,	,	,
cord-259603-bh198xgl	307	3	2014	2014	CD
cord-259603-bh198xgl	307	4	.	.	.
cord-259603-bh198xgl	308	1	Although	although	IN
cord-259603-bh198xgl	308	2	ribavirin	ribavirin	NN
cord-259603-bh198xgl	308	3	was	be	VBD
cord-259603-bh198xgl	308	4	used	use	VBN
cord-259603-bh198xgl	308	5	to	to	TO
cord-259603-bh198xgl	308	6	treat	treat	VB
cord-259603-bh198xgl	308	7	small	small	JJ
cord-259603-bh198xgl	308	8	numbers	number	NNS
cord-259603-bh198xgl	308	9	of	of	IN
cord-259603-bh198xgl	308	10	SARS	SARS	NNP
cord-259603-bh198xgl	308	11	and	and	CC
cord-259603-bh198xgl	308	12	MERS	MERS	NNP
cord-259603-bh198xgl	308	13	patients	patient	NNS
cord-259603-bh198xgl	308	14	,	,	,
cord-259603-bh198xgl	308	15	high	high	JJ
cord-259603-bh198xgl	308	16	doses	dose	NNS
cord-259603-bh198xgl	308	17	were	be	VBD
cord-259603-bh198xgl	308	18	used	use	VBN
cord-259603-bh198xgl	308	19	and	and	CC
cord-259603-bh198xgl	308	20	the	the	DT
cord-259603-bh198xgl	308	21	benefits	benefit	NNS
cord-259603-bh198xgl	308	22	of	of	IN
cord-259603-bh198xgl	308	23	the	the	DT
cord-259603-bh198xgl	308	24	treatment	treatment	NN
cord-259603-bh198xgl	308	25	remained	remain	VBD
cord-259603-bh198xgl	308	26	essentially	essentially	RB
cord-259603-bh198xgl	308	27	unclear	unclear	JJ
cord-259603-bh198xgl	309	1	(	(	-LRB-
cord-259603-bh198xgl	309	2	Zumla	Zumla	NNP
cord-259603-bh198xgl	309	3	et	et	NNP
cord-259603-bh198xgl	309	4	al	al	NNP
cord-259603-bh198xgl	309	5	.	.	NNP
cord-259603-bh198xgl	309	6	,	,	,
cord-259603-bh198xgl	309	7	2016	2016	CD
cord-259603-bh198xgl	309	8	)	)	-RRB-
cord-259603-bh198xgl	309	9	.	.	.
cord-259603-bh198xgl	310	1	Experiments	experiment	NNS
cord-259603-bh198xgl	310	2	with	with	IN
cord-259603-bh198xgl	310	3	different	different	JJ
cord-259603-bh198xgl	310	4	CoVs	covs	NN
cord-259603-bh198xgl	310	5	in	in	IN
cord-259603-bh198xgl	310	6	animal	animal	NN
cord-259603-bh198xgl	310	7	models	model	NNS
cord-259603-bh198xgl	311	1	Falzarano	Falzarano	NNP
cord-259603-bh198xgl	311	2	et	et	FW
cord-259603-bh198xgl	311	3	al	al	NNP
cord-259603-bh198xgl	311	4	.	.	NNP
cord-259603-bh198xgl	311	5	,	,	,
cord-259603-bh198xgl	311	6	2013	2013	CD
cord-259603-bh198xgl	311	7	)	)	-RRB-
cord-259603-bh198xgl	311	8	and	and	CC
cord-259603-bh198xgl	311	9	infected	infected	JJ
cord-259603-bh198xgl	311	10	cell	cell	NN
cord-259603-bh198xgl	311	11	cultures	culture	NNS
cord-259603-bh198xgl	312	1	(	(	-LRB-
cord-259603-bh198xgl	312	2	Ikejiri	Ikejiri	NNP
cord-259603-bh198xgl	312	3	et	et	FW
cord-259603-bh198xgl	312	4	al	al	NNP
cord-259603-bh198xgl	312	5	.	.	NNP
cord-259603-bh198xgl	312	6	,	,	,
cord-259603-bh198xgl	312	7	2007	2007	CD
cord-259603-bh198xgl	313	1	;	;	:
cord-259603-bh198xgl	313	2	Pyrc	Pyrc	NNP
cord-259603-bh198xgl	313	3	et	et	NNP
cord-259603-bh198xgl	313	4	al	al	NNP
cord-259603-bh198xgl	313	5	.	.	NNP
cord-259603-bh198xgl	313	6	,	,	,
cord-259603-bh198xgl	313	7	2006	2006	CD
cord-259603-bh198xgl	313	8	)	)	-RRB-
cord-259603-bh198xgl	313	9	also	also	RB
cord-259603-bh198xgl	313	10	established	establish	VBD
cord-259603-bh198xgl	313	11	its	-PRON-	PRP$
cord-259603-bh198xgl	313	12	poor	poor	JJ
cord-259603-bh198xgl	313	13	activity	activity	NN
cord-259603-bh198xgl	313	14	and	and	CC
cord-259603-bh198xgl	313	15	strongly	strongly	RB
cord-259603-bh198xgl	313	16	suggested	suggest	VBD
cord-259603-bh198xgl	313	17	that	that	IN
cord-259603-bh198xgl	313	18	ribavirin	ribavirin	NN
cord-259603-bh198xgl	313	19	does	do	VBZ
cord-259603-bh198xgl	313	20	not	not	RB
cord-259603-bh198xgl	313	21	target	target	VB
cord-259603-bh198xgl	313	22	the	the	DT
cord-259603-bh198xgl	313	23	CoV	cov	NN
cord-259603-bh198xgl	313	24	RdRp	RdRp	NNP
cord-259603-bh198xgl	313	25	directly	directly	RB
cord-259603-bh198xgl	313	26	or	or	CC
cord-259603-bh198xgl	313	27	is	be	VBZ
cord-259603-bh198xgl	313	28	targeted	target	VBN
cord-259603-bh198xgl	313	29	(	(	-LRB-
cord-259603-bh198xgl	313	30	itself	-PRON-	PRP
cord-259603-bh198xgl	313	31	)	)	-RRB-
cord-259603-bh198xgl	313	32	by	by	IN
cord-259603-bh198xgl	313	33	the	the	DT
cord-259603-bh198xgl	313	34	nsp14-ExoN	nsp14-ExoN	NNP
cord-259603-bh198xgl	313	35	activity	activity	NN
cord-259603-bh198xgl	314	1	(	(	-LRB-
cord-259603-bh198xgl	314	2	Smith	Smith	NNP
cord-259603-bh198xgl	314	3	et	et	NNP
cord-259603-bh198xgl	314	4	al	al	NNP
cord-259603-bh198xgl	314	5	.	.	.
cord-259603-bh198xgl	315	1	,	,	,
cord-259603-bh198xgl	315	2	2013	2013	CD
cord-259603-bh198xgl	315	3	)	)	-RRB-
cord-259603-bh198xgl	315	4	.	.	.
cord-259603-bh198xgl	316	1	Innovative	innovative	JJ
cord-259603-bh198xgl	316	2	nucleoside	nucleoside	NN
cord-259603-bh198xgl	316	3	inhibitors	inhibitor	NNS
cord-259603-bh198xgl	316	4	continue	continue	VBP
cord-259603-bh198xgl	316	5	to	to	TO
cord-259603-bh198xgl	316	6	be	be	VB
cord-259603-bh198xgl	316	7	identified	identify	VBN
cord-259603-bh198xgl	316	8	or	or	CC
cord-259603-bh198xgl	316	9	developed	develop	VBN
cord-259603-bh198xgl	316	10	(	(	-LRB-
cord-259603-bh198xgl	316	11	Peters	Peters	NNP
cord-259603-bh198xgl	316	12	et	et	NNP
cord-259603-bh198xgl	316	13	al	al	NNP
cord-259603-bh198xgl	316	14	.	.	NNP
cord-259603-bh198xgl	316	15	,	,	,
cord-259603-bh198xgl	316	16	2015	2015	CD
cord-259603-bh198xgl	316	17	;	;	:
cord-259603-bh198xgl	316	18	Warren	Warren	NNP
cord-259603-bh198xgl	316	19	et	et	NNP
cord-259603-bh198xgl	316	20	al	al	NNP
cord-259603-bh198xgl	316	21	.	.	NNP
cord-259603-bh198xgl	316	22	,	,	,
cord-259603-bh198xgl	316	23	2014	2014	CD
cord-259603-bh198xgl	316	24	)	)	-RRB-
cord-259603-bh198xgl	316	25	and	and	CC
cord-259603-bh198xgl	316	26	the	the	DT
cord-259603-bh198xgl	316	27	recently	recently	RB
cord-259603-bh198xgl	316	28	described	describe	VBN
cord-259603-bh198xgl	316	29	in	in	IN
cord-259603-bh198xgl	316	30	vitro	vitro	FW
cord-259603-bh198xgl	316	31	RdRp	rdrp	NN
cord-259603-bh198xgl	316	32	assay	assay	NN
cord-259603-bh198xgl	316	33	(	(	-LRB-
cord-259603-bh198xgl	316	34	Subissi	Subissi	NNP
cord-259603-bh198xgl	316	35	et	et	NNP
cord-259603-bh198xgl	316	36	al	al	NNP
cord-259603-bh198xgl	316	37	.	.	NNP
cord-259603-bh198xgl	316	38	,	,	,
cord-259603-bh198xgl	316	39	2014b	2014b	CD
cord-259603-bh198xgl	316	40	)	)	-RRB-
cord-259603-bh198xgl	316	41	may	may	MD
cord-259603-bh198xgl	316	42	prove	prove	VB
cord-259603-bh198xgl	316	43	very	very	RB
cord-259603-bh198xgl	316	44	useful	useful	JJ
cord-259603-bh198xgl	316	45	for	for	IN
cord-259603-bh198xgl	316	46	establishing	establish	VBG
cord-259603-bh198xgl	316	47	their	-PRON-	PRP$
cord-259603-bh198xgl	316	48	mechanism	mechanism	NN
cord-259603-bh198xgl	316	49	of	of	IN
cord-259603-bh198xgl	316	50	inhibition	inhibition	NN
cord-259603-bh198xgl	316	51	more	more	RBR
cord-259603-bh198xgl	316	52	precisely	precisely	RB
cord-259603-bh198xgl	316	53	.	.	.
cord-259603-bh198xgl	317	1	A	a	DT
cord-259603-bh198xgl	317	2	better	well	JJR
cord-259603-bh198xgl	317	3	understanding	understanding	NN
cord-259603-bh198xgl	317	4	of	of	IN
cord-259603-bh198xgl	317	5	nsp12-RdRp	nsp12-RdRp	NNP
cord-259603-bh198xgl	317	6	structure	structure	NN
cord-259603-bh198xgl	317	7	and	and	CC
cord-259603-bh198xgl	317	8	function	function	NN
cord-259603-bh198xgl	317	9	will	will	MD
cord-259603-bh198xgl	317	10	also	also	RB
cord-259603-bh198xgl	317	11	be	be	VB
cord-259603-bh198xgl	317	12	required	require	VBN
cord-259603-bh198xgl	317	13	to	to	TO
cord-259603-bh198xgl	317	14	design	design	VB
cord-259603-bh198xgl	317	15	strategies	strategy	NNS
cord-259603-bh198xgl	317	16	that	that	WDT
cord-259603-bh198xgl	317	17	minimize	minimize	VBP
cord-259603-bh198xgl	317	18	the	the	DT
cord-259603-bh198xgl	317	19	impact	impact	NN
cord-259603-bh198xgl	317	20	of	of	IN
cord-259603-bh198xgl	317	21	drug	drug	NN
cord-259603-bh198xgl	317	22	resistance	resistance	NN
cord-259603-bh198xgl	317	23	-	-	HYPH
cord-259603-bh198xgl	317	24	inducing	induce	VBG
cord-259603-bh198xgl	317	25	mutations	mutation	NNS
cord-259603-bh198xgl	317	26	,	,	,
cord-259603-bh198xgl	317	27	which	which	WDT
cord-259603-bh198xgl	317	28	are	be	VBP
cord-259603-bh198xgl	317	29	a	a	DT
cord-259603-bh198xgl	317	30	common	common	JJ
cord-259603-bh198xgl	317	31	problem	problem	NN
cord-259603-bh198xgl	317	32	when	when	WRB
cord-259603-bh198xgl	317	33	targeting	target	VBG
cord-259603-bh198xgl	317	34	enzymes	enzyme	NNS
cord-259603-bh198xgl	317	35	of	of	IN
cord-259603-bh198xgl	317	36	rapidly	rapidly	RB
cord-259603-bh198xgl	317	37	evolving	evolve	VBG
cord-259603-bh198xgl	317	38	RNA	RNA	NNP
cord-259603-bh198xgl	317	39	viruses	virus	NNS
cord-259603-bh198xgl	317	40	.	.	.
cord-259603-bh198xgl	318	1	Since	since	IN
cord-259603-bh198xgl	318	2	the	the	DT
cord-259603-bh198xgl	318	3	delineation	delineation	NN
cord-259603-bh198xgl	318	4	of	of	IN
cord-259603-bh198xgl	318	5	the	the	DT
cord-259603-bh198xgl	318	6	borders	border	NNS
cord-259603-bh198xgl	318	7	of	of	IN
cord-259603-bh198xgl	318	8	the	the	DT
cord-259603-bh198xgl	318	9	CoV	CoV	NNP
cord-259603-bh198xgl	318	10	RdRp	RdRp	NNP
cord-259603-bh198xgl	318	11	-	-	HYPH
cord-259603-bh198xgl	318	12	containing	contain	VBG
cord-259603-bh198xgl	318	13	replicase	replicase	NN
cord-259603-bh198xgl	318	14	cleavage	cleavage	NN
cord-259603-bh198xgl	318	15	product	product	NN
cord-259603-bh198xgl	319	1	(	(	-LRB-
cord-259603-bh198xgl	319	2	Boursnell	Boursnell	NNP
cord-259603-bh198xgl	319	3	et	et	FW
cord-259603-bh198xgl	319	4	al	al	NNP
cord-259603-bh198xgl	319	5	.	.	NNP
cord-259603-bh198xgl	319	6	,	,	,
cord-259603-bh198xgl	319	7	1987	1987	CD
cord-259603-bh198xgl	319	8	;	;	:
cord-259603-bh198xgl	319	9	Gorbalenya	Gorbalenya	NNP
cord-259603-bh198xgl	319	10	et	et	NNP
cord-259603-bh198xgl	319	11	al	al	NNP
cord-259603-bh198xgl	319	12	.	.	NNP
cord-259603-bh198xgl	319	13	,	,	,
cord-259603-bh198xgl	319	14	1989	1989	CD
cord-259603-bh198xgl	319	15	)	)	-RRB-
cord-259603-bh198xgl	319	16	,	,	,
cord-259603-bh198xgl	319	17	which	which	WDT
cord-259603-bh198xgl	319	18	is	be	VBZ
cord-259603-bh198xgl	319	19	now	now	RB
cord-259603-bh198xgl	319	20	known	know	VBN
cord-259603-bh198xgl	319	21	as	as	IN
cord-259603-bh198xgl	319	22	nsp12	nsp12	CD
cord-259603-bh198xgl	319	23	,	,	,
cord-259603-bh198xgl	319	24	it	-PRON-	PRP
cord-259603-bh198xgl	319	25	had	have	VBD
cord-259603-bh198xgl	319	26	been	be	VBN
cord-259603-bh198xgl	319	27	clear	clear	JJ
cord-259603-bh198xgl	319	28	that	that	IN
cord-259603-bh198xgl	319	29	the	the	DT
cord-259603-bh198xgl	319	30	protein	protein	NN
cord-259603-bh198xgl	319	31	must	must	MD
cord-259603-bh198xgl	319	32	be	be	VB
cord-259603-bh198xgl	319	33	a	a	DT
cord-259603-bh198xgl	319	34	multidomain	multidomain	NN
cord-259603-bh198xgl	319	35	subunit	subunit	NN
cord-259603-bh198xgl	319	36	,	,	,
cord-259603-bh198xgl	319	37	with	with	IN
cord-259603-bh198xgl	319	38	the	the	DT
cord-259603-bh198xgl	319	39	canonical	canonical	JJ
cord-259603-bh198xgl	319	40	RdRp	RdRp	NNP
cord-259603-bh198xgl	319	41	domain	domain	NN
cord-259603-bh198xgl	319	42	roughly	roughly	RB
cord-259603-bh198xgl	319	43	occupying	occupy	VBG
cord-259603-bh198xgl	319	44	its	-PRON-	PRP$
cord-259603-bh198xgl	319	45	C	c	NN
cord-259603-bh198xgl	319	46	-	-	HYPH
cord-259603-bh198xgl	319	47	terminal	terminal	NN
cord-259603-bh198xgl	319	48	half	half	NN
cord-259603-bh198xgl	319	49	(	(	-LRB-
cord-259603-bh198xgl	319	50	Fig	Fig	NNP
cord-259603-bh198xgl	319	51	.	.	.
cord-259603-bh198xgl	319	52	3A	3A	NNP
cord-259603-bh198xgl	319	53	)	)	-RRB-
cord-259603-bh198xgl	319	54	.	.	.
cord-259603-bh198xgl	320	1	Only	only	RB
cord-259603-bh198xgl	320	2	recently	recently	RB
cord-259603-bh198xgl	320	3	,	,	,
cord-259603-bh198xgl	320	4	first	first	JJ
cord-259603-bh198xgl	320	5	clues	clue	NNS
cord-259603-bh198xgl	320	6	to	to	IN
cord-259603-bh198xgl	320	7	some	some	DT
cord-259603-bh198xgl	320	8	of	of	IN
cord-259603-bh198xgl	320	9	the	the	DT
cord-259603-bh198xgl	320	10	properties	property	NNS
cord-259603-bh198xgl	320	11	and	and	CC
cord-259603-bh198xgl	320	12	possible	possible	JJ
cord-259603-bh198xgl	320	13	functions	function	NNS
cord-259603-bh198xgl	320	14	of	of	IN
cord-259603-bh198xgl	320	15	the	the	DT
cord-259603-bh198xgl	320	16	N	n	CD
cord-259603-bh198xgl	320	17	-	-	HYPH
cord-259603-bh198xgl	320	18	terminal	terminal	JJ
cord-259603-bh198xgl	320	19	part	part	NN
cord-259603-bh198xgl	320	20	of	of	IN
cord-259603-bh198xgl	320	21	nsp12	nsp12	CD
cord-259603-bh198xgl	320	22	were	be	VBD
cord-259603-bh198xgl	320	23	obtained	obtain	VBN
cord-259603-bh198xgl	320	24	(	(	-LRB-
cord-259603-bh198xgl	320	25	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	320	26	et	et	NNP
cord-259603-bh198xgl	320	27	al	al	NNP
cord-259603-bh198xgl	320	28	.	.	NNP
cord-259603-bh198xgl	320	29	,	,	,
cord-259603-bh198xgl	320	30	2015a	2015a	CD
cord-259603-bh198xgl	320	31	)	)	-RRB-
cord-259603-bh198xgl	320	32	.	.	.
cord-259603-bh198xgl	321	1	A	a	DT
cord-259603-bh198xgl	321	2	renewed	renew	VBN
cord-259603-bh198xgl	321	3	bioinformatics	bioinformatics	NN
cord-259603-bh198xgl	321	4	analysis	analysis	NN
cord-259603-bh198xgl	321	5	across	across	IN
cord-259603-bh198xgl	321	6	the	the	DT
cord-259603-bh198xgl	321	7	(	(	-LRB-
cord-259603-bh198xgl	321	8	still	still	RB
cord-259603-bh198xgl	321	9	expanding	expand	VBG
cord-259603-bh198xgl	321	10	)	)	-RRB-
cord-259603-bh198xgl	321	11	order	order	NN
cord-259603-bh198xgl	321	12	Nidovirales	Nidovirales	NNP
cord-259603-bh198xgl	321	13	revealed	reveal	VBD
cord-259603-bh198xgl	321	14	that	that	IN
cord-259603-bh198xgl	321	15	the	the	DT
cord-259603-bh198xgl	321	16	nidoviral	nidoviral	JJ
cord-259603-bh198xgl	321	17	RdRp	RdRp	NNP
cord-259603-bh198xgl	321	18	-	-	HYPH
cord-259603-bh198xgl	321	19	containing	contain	VBG
cord-259603-bh198xgl	321	20	replicase	replicase	NN
cord-259603-bh198xgl	321	21	subunit	subunit	NN
cord-259603-bh198xgl	321	22	contains	contain	VBZ
cord-259603-bh198xgl	321	23	a	a	DT
cord-259603-bh198xgl	321	24	conserved	conserved	JJ
cord-259603-bh198xgl	321	25	N	n	CD
cord-259603-bh198xgl	321	26	-	-	HYPH
cord-259603-bh198xgl	321	27	terminal	terminal	NN
cord-259603-bh198xgl	321	28	domain	domain	NN
cord-259603-bh198xgl	321	29	of	of	IN
cord-259603-bh198xgl	321	30	200	200	CD
cord-259603-bh198xgl	321	31	-	-	SYM
cord-259603-bh198xgl	321	32	300	300	CD
cord-259603-bh198xgl	321	33	residues	residue	NNS
cord-259603-bh198xgl	321	34	(	(	-LRB-
cord-259603-bh198xgl	321	35	$	$	$
cord-259603-bh198xgl	321	36	225	225	CD
cord-259603-bh198xgl	321	37	residues	residue	NNS
cord-259603-bh198xgl	321	38	in	in	IN
cord-259603-bh198xgl	321	39	CoV	CoV	NNP
cord-259603-bh198xgl	321	40	nsp12	nsp12	CD
cord-259603-bh198xgl	321	41	;	;	:
cord-259603-bh198xgl	321	42	Fig	Fig	NNP
cord-259603-bh198xgl	321	43	.	.	.
cord-259603-bh198xgl	321	44	3B	3B	NNP
cord-259603-bh198xgl	321	45	)	)	-RRB-
cord-259603-bh198xgl	321	46	.	.	.
cord-259603-bh198xgl	322	1	In	in	IN
cord-259603-bh198xgl	322	2	CoV	CoV	NNP
cord-259603-bh198xgl	322	3	nsp12	nsp12	CD
cord-259603-bh198xgl	322	4	,	,	,
cord-259603-bh198xgl	322	5	about	about	IN
cord-259603-bh198xgl	322	6	175	175	CD
cord-259603-bh198xgl	322	7	residues	residue	NNS
cord-259603-bh198xgl	322	8	separate	separate	VBP
cord-259603-bh198xgl	322	9	the	the	DT
cord-259603-bh198xgl	322	10	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	322	11	and	and	CC
cord-259603-bh198xgl	322	12	RdRp	RdRp	NNP
cord-259603-bh198xgl	322	13	domains	domain	NNS
cord-259603-bh198xgl	322	14	,	,	,
cord-259603-bh198xgl	322	15	leaving	leave	VBG
cord-259603-bh198xgl	322	16	space	space	NN
cord-259603-bh198xgl	322	17	for	for	IN
cord-259603-bh198xgl	322	18	the	the	DT
cord-259603-bh198xgl	322	19	presence	presence	NN
cord-259603-bh198xgl	322	20	of	of	IN
cord-259603-bh198xgl	322	21	an	an	DT
cord-259603-bh198xgl	322	22	additional	additional	JJ
cord-259603-bh198xgl	322	23	domain	domain	NN
cord-259603-bh198xgl	322	24	between	between	IN
cord-259603-bh198xgl	322	25	the	the	DT
cord-259603-bh198xgl	322	26	two	two	CD
cord-259603-bh198xgl	322	27	.	.	.
cord-259603-bh198xgl	323	1	Based	base	VBN
cord-259603-bh198xgl	323	2	mainly	mainly	RB
cord-259603-bh198xgl	323	3	on	on	IN
cord-259603-bh198xgl	323	4	biochemical	biochemical	JJ
cord-259603-bh198xgl	323	5	data	datum	NNS
cord-259603-bh198xgl	323	6	obtained	obtain	VBN
cord-259603-bh198xgl	323	7	with	with	IN
cord-259603-bh198xgl	323	8	the	the	DT
cord-259603-bh198xgl	323	9	arterivirus	arterivirus	NNP
cord-259603-bh198xgl	323	10	homolog	homolog	NN
cord-259603-bh198xgl	323	11	(	(	-LRB-
cord-259603-bh198xgl	323	12	see	see	VB
cord-259603-bh198xgl	323	13	later	later	RBR
cord-259603-bh198xgl	323	14	)	)	-RRB-
cord-259603-bh198xgl	323	15	,	,	,
cord-259603-bh198xgl	323	16	the	the	DT
cord-259603-bh198xgl	323	17	N	n	CD
cord-259603-bh198xgl	323	18	-	-	HYPH
cord-259603-bh198xgl	323	19	terminal	terminal	NN
cord-259603-bh198xgl	323	20	domain	domain	NN
cord-259603-bh198xgl	323	21	was	be	VBD
cord-259603-bh198xgl	323	22	concluded	conclude	VBN
cord-259603-bh198xgl	323	23	to	to	TO
cord-259603-bh198xgl	323	24	possess	possess	VB
cord-259603-bh198xgl	323	25	an	an	DT
cord-259603-bh198xgl	323	26	essential	essential	JJ
cord-259603-bh198xgl	323	27	nucleotidylation	nucleotidylation	NN
cord-259603-bh198xgl	323	28	activity	activity	NN
cord-259603-bh198xgl	323	29	and	and	CC
cord-259603-bh198xgl	323	30	hence	hence	RB
cord-259603-bh198xgl	323	31	it	-PRON-	PRP
cord-259603-bh198xgl	323	32	was	be	VBD
cord-259603-bh198xgl	323	33	coined	coin	VBN
cord-259603-bh198xgl	323	34	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	323	35	RdRp	RdRp	NNP
cord-259603-bh198xgl	323	36	-	-	HYPH
cord-259603-bh198xgl	323	37	associated	associate	VBN
cord-259603-bh198xgl	323	38	nucleotidyltransferase	nucleotidyltransferase	NNP
cord-259603-bh198xgl	323	39	(	(	-LRB-
cord-259603-bh198xgl	323	40	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	323	41	)	)	-RRB-
cord-259603-bh198xgl	324	1	(	(	-LRB-
cord-259603-bh198xgl	324	2	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	324	3	et	et	NNP
cord-259603-bh198xgl	324	4	al	al	NNP
cord-259603-bh198xgl	324	5	.	.	NNP
cord-259603-bh198xgl	324	6	,	,	,
cord-259603-bh198xgl	324	7	2015a	2015a	CD
cord-259603-bh198xgl	324	8	)	)	-RRB-
cord-259603-bh198xgl	324	9	.	.	.
cord-259603-bh198xgl	325	1	NiRAN	niran	JJ
cord-259603-bh198xgl	325	2	conservation	conservation	NN
cord-259603-bh198xgl	325	3	was	be	VBD
cord-259603-bh198xgl	325	4	found	find	VBN
cord-259603-bh198xgl	325	5	to	to	TO
cord-259603-bh198xgl	325	6	be	be	VB
cord-259603-bh198xgl	325	7	lower	low	JJR
cord-259603-bh198xgl	325	8	than	than	IN
cord-259603-bh198xgl	325	9	that	that	DT
cord-259603-bh198xgl	325	10	of	of	IN
cord-259603-bh198xgl	325	11	the	the	DT
cord-259603-bh198xgl	325	12	downstream	downstream	JJ
cord-259603-bh198xgl	325	13	RdRp	RdRp	NNP
cord-259603-bh198xgl	325	14	domain	domain	NN
cord-259603-bh198xgl	325	15	(	(	-LRB-
cord-259603-bh198xgl	325	16	Fig	Fig	NNP
cord-259603-bh198xgl	325	17	.	.	.
cord-259603-bh198xgl	325	18	3A	3A	NNP
cord-259603-bh198xgl	325	19	)	)	-RRB-
cord-259603-bh198xgl	325	20	,	,	,
cord-259603-bh198xgl	325	21	but	but	CC
cord-259603-bh198xgl	325	22	the	the	DT
cord-259603-bh198xgl	325	23	analysis	analysis	NN
cord-259603-bh198xgl	325	24	suggested	suggest	VBD
cord-259603-bh198xgl	325	25	that	that	IN
cord-259603-bh198xgl	325	26	the	the	DT
cord-259603-bh198xgl	325	27	evolutionary	evolutionary	JJ
cord-259603-bh198xgl	325	28	constraints	constraint	NNS
cord-259603-bh198xgl	325	29	on	on	IN
cord-259603-bh198xgl	325	30	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	325	31	have	have	VBP
cord-259603-bh198xgl	325	32	been	be	VBN
cord-259603-bh198xgl	325	33	similar	similar	JJ
cord-259603-bh198xgl	325	34	in	in	IN
cord-259603-bh198xgl	325	35	different	different	JJ
cord-259603-bh198xgl	325	36	nidovirus	nidovirus	NN
cord-259603-bh198xgl	325	37	lineages	lineage	NNS
cord-259603-bh198xgl	325	38	,	,	,
cord-259603-bh198xgl	325	39	which	which	WDT
cord-259603-bh198xgl	325	40	would	would	MD
cord-259603-bh198xgl	325	41	be	be	VB
cord-259603-bh198xgl	325	42	in	in	IN
cord-259603-bh198xgl	325	43	line	line	NN
cord-259603-bh198xgl	325	44	with	with	IN
cord-259603-bh198xgl	325	45	a	a	DT
cord-259603-bh198xgl	325	46	conserved	conserved	JJ
cord-259603-bh198xgl	325	47	function	function	NN
cord-259603-bh198xgl	325	48	.	.	.
cord-259603-bh198xgl	326	1	Gorbalenya	gorbalenya	NN
cord-259603-bh198xgl	326	2	and	and	CC
cord-259603-bh198xgl	326	3	colleagues	colleague	NNS
cord-259603-bh198xgl	326	4	identified	identify	VBD
cord-259603-bh198xgl	326	5	three	three	CD
cord-259603-bh198xgl	326	6	key	key	JJ
cord-259603-bh198xgl	326	7	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	326	8	motifs	motif	NNS
cord-259603-bh198xgl	326	9	(	(	-LRB-
cord-259603-bh198xgl	326	10	A	a	NN
cord-259603-bh198xgl	326	11	-	-	HYPH
cord-259603-bh198xgl	326	12	B	b	NN
cord-259603-bh198xgl	326	13	-	-	HYPH
cord-259603-bh198xgl	326	14	C	C	NNP
cord-259603-bh198xgl	326	15	)	)	-RRB-
cord-259603-bh198xgl	326	16	containing	contain	VBG
cord-259603-bh198xgl	326	17	seven	seven	CD
cord-259603-bh198xgl	326	18	invariant	invariant	JJ
cord-259603-bh198xgl	326	19	residues	residue	NNS
cord-259603-bh198xgl	326	20	(	(	-LRB-
cord-259603-bh198xgl	326	21	Fig	fig	NN
cord-259603-bh198xgl	326	22	.	.	.
cord-259603-bh198xgl	326	23	3B	3B	NNP
cord-259603-bh198xgl	326	24	)	)	-RRB-
cord-259603-bh198xgl	326	25	,	,	,
cord-259603-bh198xgl	326	26	with	with	IN
cord-259603-bh198xgl	326	27	domains	domain	NNS
cord-259603-bh198xgl	326	28	B	b	NN
cord-259603-bh198xgl	326	29	and	and	CC
cord-259603-bh198xgl	326	30	C	c	NN
cord-259603-bh198xgl	326	31	being	be	VBG
cord-259603-bh198xgl	326	32	most	most	RBS
cord-259603-bh198xgl	326	33	conserved	conserve	VBN
cord-259603-bh198xgl	326	34	(	(	-LRB-
cord-259603-bh198xgl	326	35	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	326	36	et	et	NNP
cord-259603-bh198xgl	326	37	al	al	NNP
cord-259603-bh198xgl	326	38	.	.	NNP
cord-259603-bh198xgl	326	39	,	,	,
cord-259603-bh198xgl	326	40	2015a	2015a	CD
cord-259603-bh198xgl	326	41	)	)	-RRB-
cord-259603-bh198xgl	326	42	.	.	.
cord-259603-bh198xgl	327	1	The	the	DT
cord-259603-bh198xgl	327	2	identification	identification	NN
cord-259603-bh198xgl	327	3	of	of	IN
cord-259603-bh198xgl	327	4	the	the	DT
cord-259603-bh198xgl	327	5	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	327	6	domain	domain	NN
cord-259603-bh198xgl	327	7	was	be	VBD
cord-259603-bh198xgl	327	8	further	further	RB
cord-259603-bh198xgl	327	9	supported	support	VBN
cord-259603-bh198xgl	327	10	by	by	IN
cord-259603-bh198xgl	327	11	the	the	DT
cord-259603-bh198xgl	327	12	conservation	conservation	NN
cord-259603-bh198xgl	327	13	of	of	IN
cord-259603-bh198xgl	327	14	its	-PRON-	PRP$
cord-259603-bh198xgl	327	15	predicted	predict	VBN
cord-259603-bh198xgl	327	16	secondary	secondary	JJ
cord-259603-bh198xgl	327	17	structure	structure	NN
cord-259603-bh198xgl	327	18	elements	element	NNS
cord-259603-bh198xgl	327	19	in	in	IN
cord-259603-bh198xgl	327	20	different	different	JJ
cord-259603-bh198xgl	327	21	nidovirus	nidovirus	NN
cord-259603-bh198xgl	327	22	families	family	NNS
cord-259603-bh198xgl	327	23	(	(	-LRB-
cord-259603-bh198xgl	327	24	Fig	Fig	NNP
cord-259603-bh198xgl	327	25	.	.	.
cord-259603-bh198xgl	327	26	3A	3A	NNP
cord-259603-bh198xgl	327	27	)	)	-RRB-
cord-259603-bh198xgl	327	28	.	.	.
cord-259603-bh198xgl	328	1	Extensive	extensive	JJ
cord-259603-bh198xgl	328	2	database	database	NN
cord-259603-bh198xgl	328	3	searches	search	NNS
cord-259603-bh198xgl	328	4	did	do	VBD
cord-259603-bh198xgl	328	5	not	not	RB
cord-259603-bh198xgl	328	6	reveal	reveal	VB
cord-259603-bh198xgl	328	7	potential	potential	JJ
cord-259603-bh198xgl	328	8	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	328	9	homologs	homolog	NNS
cord-259603-bh198xgl	328	10	in	in	IN
cord-259603-bh198xgl	328	11	either	either	CC
cord-259603-bh198xgl	328	12	the	the	DT
cord-259603-bh198xgl	328	13	viral	viral	JJ
cord-259603-bh198xgl	328	14	or	or	CC
cord-259603-bh198xgl	328	15	the	the	DT
cord-259603-bh198xgl	328	16	cellular	cellular	JJ
cord-259603-bh198xgl	328	17	world	world	NN
cord-259603-bh198xgl	328	18	,	,	,
cord-259603-bh198xgl	328	19	although	although	IN
cord-259603-bh198xgl	328	20	it	-PRON-	PRP
cord-259603-bh198xgl	328	21	can	can	MD
cord-259603-bh198xgl	328	22	not	not	RB
cord-259603-bh198xgl	328	23	be	be	VB
cord-259603-bh198xgl	328	24	excluded	exclude	VBN
cord-259603-bh198xgl	328	25	that	that	IN
cord-259603-bh198xgl	328	26	the	the	DT
cord-259603-bh198xgl	328	27	domain	domain	NN
cord-259603-bh198xgl	328	28	has	have	VBZ
cord-259603-bh198xgl	328	29	diverged	diverge	VBN
cord-259603-bh198xgl	328	30	from	from	IN
cord-259603-bh198xgl	328	31	cellular	cellular	JJ
cord-259603-bh198xgl	328	32	ancestors	ancestor	NNS
cord-259603-bh198xgl	328	33	to	to	IN
cord-259603-bh198xgl	328	34	a	a	DT
cord-259603-bh198xgl	328	35	level	level	NN
cord-259603-bh198xgl	328	36	that	that	WDT
cord-259603-bh198xgl	328	37	prevents	prevent	VBZ
cord-259603-bh198xgl	328	38	their	-PRON-	PRP$
cord-259603-bh198xgl	328	39	identification	identification	NN
cord-259603-bh198xgl	328	40	with	with	IN
cord-259603-bh198xgl	328	41	the	the	DT
cord-259603-bh198xgl	328	42	currently	currently	RB
cord-259603-bh198xgl	328	43	available	available	JJ
cord-259603-bh198xgl	328	44	sequences	sequence	NNS
cord-259603-bh198xgl	328	45	and	and	CC
cord-259603-bh198xgl	328	46	tools	tool	NNS
cord-259603-bh198xgl	328	47	.	.	.
cord-259603-bh198xgl	329	1	Nevertheless	nevertheless	RB
cord-259603-bh198xgl	329	2	,	,	,
cord-259603-bh198xgl	329	3	its	-PRON-	PRP$
cord-259603-bh198xgl	329	4	unique	unique	JJ
cord-259603-bh198xgl	329	5	presence	presence	NN
cord-259603-bh198xgl	329	6	in	in	IN
cord-259603-bh198xgl	329	7	nidoviruses	nidoviruse	NNS
cord-259603-bh198xgl	329	8	and	and	CC
cord-259603-bh198xgl	329	9	its	-PRON-	PRP$
cord-259603-bh198xgl	329	10	association	association	NN
cord-259603-bh198xgl	329	11	with	with	IN
cord-259603-bh198xgl	329	12	the	the	DT
cord-259603-bh198xgl	329	13	important	important	JJ
cord-259603-bh198xgl	329	14	RdRp	RdRp	NNP
cord-259603-bh198xgl	329	15	domain	domain	NN
cord-259603-bh198xgl	329	16	suggest	suggest	VBP
cord-259603-bh198xgl	329	17	that	that	IN
cord-259603-bh198xgl	329	18	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	329	19	may	may	MD
cord-259603-bh198xgl	329	20	be	be	VB
cord-259603-bh198xgl	329	21	a	a	DT
cord-259603-bh198xgl	329	22	crucial	crucial	JJ
cord-259603-bh198xgl	329	23	regulator	regulator	NN
cord-259603-bh198xgl	329	24	or	or	CC
cord-259603-bh198xgl	329	25	interaction	interaction	NN
cord-259603-bh198xgl	329	26	partner	partner	NN
cord-259603-bh198xgl	329	27	of	of	IN
cord-259603-bh198xgl	329	28	the	the	DT
cord-259603-bh198xgl	329	29	downstream	downstream	JJ
cord-259603-bh198xgl	329	30	RdRp	RdRp	NNP
cord-259603-bh198xgl	329	31	domain	domain	NN
cord-259603-bh198xgl	329	32	that	that	WDT
cord-259603-bh198xgl	329	33	must	must	MD
cord-259603-bh198xgl	329	34	have	have	VB
cord-259603-bh198xgl	329	35	been	be	VBN
cord-259603-bh198xgl	329	36	acquired	acquire	VBN
cord-259603-bh198xgl	329	37	before	before	IN
cord-259603-bh198xgl	329	38	the	the	DT
cord-259603-bh198xgl	329	39	currently	currently	RB
cord-259603-bh198xgl	329	40	known	know	VBN
cord-259603-bh198xgl	329	41	nidovirus	nidovirus	NN
cord-259603-bh198xgl	329	42	lineages	lineage	NNS
cord-259603-bh198xgl	329	43	diverged	diverge	VBD
cord-259603-bh198xgl	329	44	.	.	.
cord-259603-bh198xgl	330	1	NiRAN	niran	JJ
cord-259603-bh198xgl	331	1	and	and	CC
cord-259603-bh198xgl	331	2	the	the	DT
cord-259603-bh198xgl	331	3	zinc	zinc	NN
cord-259603-bh198xgl	331	4	-	-	HYPH
cord-259603-bh198xgl	331	5	binding	bind	VBG
cord-259603-bh198xgl	331	6	domain	domain	NN
cord-259603-bh198xgl	331	7	(	(	-LRB-
cord-259603-bh198xgl	331	8	ZBD	ZBD	NNP
cord-259603-bh198xgl	331	9	)	)	-RRB-
cord-259603-bh198xgl	331	10	that	that	WDT
cord-259603-bh198xgl	331	11	is	be	VBZ
cord-259603-bh198xgl	331	12	associated	associate	VBN
cord-259603-bh198xgl	331	13	with	with	IN
cord-259603-bh198xgl	331	14	the	the	DT
cord-259603-bh198xgl	331	15	nsp13-helicase	nsp13-helicase	JJ
cord-259603-bh198xgl	331	16	protein	protein	NN
cord-259603-bh198xgl	331	17	(	(	-LRB-
cord-259603-bh198xgl	331	18	see	see	VB
cord-259603-bh198xgl	331	19	later	later	RBR
cord-259603-bh198xgl	331	20	)	)	-RRB-
cord-259603-bh198xgl	331	21	are	be	VBP
cord-259603-bh198xgl	331	22	the	the	DT
cord-259603-bh198xgl	331	23	only	only	JJ
cord-259603-bh198xgl	331	24	unique	unique	JJ
cord-259603-bh198xgl	331	25	genetic	genetic	JJ
cord-259603-bh198xgl	331	26	markers	marker	NNS
cord-259603-bh198xgl	331	27	of	of	IN
cord-259603-bh198xgl	331	28	the	the	DT
cord-259603-bh198xgl	331	29	order	order	NN
cord-259603-bh198xgl	331	30	Nidovirales	Nidovirales	NNP
cord-259603-bh198xgl	331	31	identified	identify	VBN
cord-259603-bh198xgl	331	32	thus	thus	RB
cord-259603-bh198xgl	331	33	far	far	RB
cord-259603-bh198xgl	331	34	.	.	.
cord-259603-bh198xgl	332	1	Mainly	mainly	RB
cord-259603-bh198xgl	332	2	due	due	IN
cord-259603-bh198xgl	332	3	to	to	IN
cord-259603-bh198xgl	332	4	the	the	DT
cord-259603-bh198xgl	332	5	lack	lack	NN
cord-259603-bh198xgl	332	6	of	of	IN
cord-259603-bh198xgl	332	7	sufficient	sufficient	JJ
cord-259603-bh198xgl	332	8	amounts	amount	NNS
cord-259603-bh198xgl	332	9	of	of	IN
cord-259603-bh198xgl	332	10	recombinant	recombinant	JJ
cord-259603-bh198xgl	332	11	CoV	CoV	NNP
cord-259603-bh198xgl	332	12	nsp12	nsp12	NNP
cord-259603-bh198xgl	332	13	,	,	,
cord-259603-bh198xgl	332	14	the	the	DT
cord-259603-bh198xgl	332	15	preliminary	preliminary	JJ
cord-259603-bh198xgl	332	16	biochemical	biochemical	JJ
cord-259603-bh198xgl	332	17	characterization	characterization	NN
cord-259603-bh198xgl	332	18	of	of	IN
cord-259603-bh198xgl	332	19	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	332	20	was	be	VBD
cord-259603-bh198xgl	332	21	restricted	restrict	VBN
cord-259603-bh198xgl	332	22	to	to	IN
cord-259603-bh198xgl	332	23	its	-PRON-	PRP$
cord-259603-bh198xgl	332	24	arterivirus	arterivirus	NN
cord-259603-bh198xgl	332	25	homolog	homolog	NN
cord-259603-bh198xgl	332	26	,	,	,
cord-259603-bh198xgl	332	27	using	use	VBG
cord-259603-bh198xgl	332	28	recombinant	recombinant	JJ
cord-259603-bh198xgl	332	29	nsp9	nsp9	DT
cord-259603-bh198xgl	332	30	of	of	IN
cord-259603-bh198xgl	332	31	equine	equine	JJ
cord-259603-bh198xgl	332	32	arteritis	arteritis	NN
cord-259603-bh198xgl	332	33	virus	virus	NN
cord-259603-bh198xgl	332	34	(	(	-LRB-
cord-259603-bh198xgl	332	35	EAV	EAV	NNP
cord-259603-bh198xgl	332	36	)	)	-RRB-
cord-259603-bh198xgl	333	1	(	(	-LRB-
cord-259603-bh198xgl	333	2	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	333	3	et	et	NNP
cord-259603-bh198xgl	333	4	al	al	NNP
cord-259603-bh198xgl	333	5	.	.	NNP
cord-259603-bh198xgl	333	6	,	,	,
cord-259603-bh198xgl	333	7	2015a	2015a	CD
cord-259603-bh198xgl	333	8	)	)	-RRB-
cord-259603-bh198xgl	333	9	.	.	.
cord-259603-bh198xgl	334	1	For	for	IN
cord-259603-bh198xgl	334	2	both	both	CC
cord-259603-bh198xgl	334	3	EAV	EAV	NNP
cord-259603-bh198xgl	334	4	and	and	CC
cord-259603-bh198xgl	334	5	SARS	SARS	NNP
cord-259603-bh198xgl	334	6	-	-	HYPH
cord-259603-bh198xgl	334	7	CoV	CoV	NNP
cord-259603-bh198xgl	334	8	,	,	,
cord-259603-bh198xgl	334	9	it	-PRON-	PRP
cord-259603-bh198xgl	334	10	could	could	MD
cord-259603-bh198xgl	334	11	be	be	VB
cord-259603-bh198xgl	334	12	shown	show	VBN
cord-259603-bh198xgl	334	13	that	that	DT
cord-259603-bh198xgl	334	14	replacement	replacement	NN
cord-259603-bh198xgl	334	15	of	of	IN
cord-259603-bh198xgl	334	16	conserved	conserve	VBN
cord-259603-bh198xgl	334	17	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	334	18	residues	residue	NNS
cord-259603-bh198xgl	334	19	can	can	MD
cord-259603-bh198xgl	334	20	cripple	cripple	VB
cord-259603-bh198xgl	334	21	or	or	CC
cord-259603-bh198xgl	334	22	completely	completely	RB
cord-259603-bh198xgl	334	23	block	block	VB
cord-259603-bh198xgl	334	24	virus	virus	NN
cord-259603-bh198xgl	334	25	replication	replication	NN
cord-259603-bh198xgl	334	26	in	in	IN
cord-259603-bh198xgl	334	27	cultured	cultured	JJ
cord-259603-bh198xgl	334	28	cells	cell	NNS
cord-259603-bh198xgl	334	29	.	.	.
cord-259603-bh198xgl	335	1	A	a	DT
cord-259603-bh198xgl	335	2	combination	combination	NN
cord-259603-bh198xgl	335	3	of	of	IN
cord-259603-bh198xgl	335	4	biochemical	biochemical	JJ
cord-259603-bh198xgl	335	5	assays	assay	NNS
cord-259603-bh198xgl	335	6	revealed	reveal	VBD
cord-259603-bh198xgl	335	7	that	that	IN
cord-259603-bh198xgl	335	8	in	in	IN
cord-259603-bh198xgl	335	9	vitro	vitro	FW
cord-259603-bh198xgl	335	10	the	the	DT
cord-259603-bh198xgl	335	11	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	335	12	domain	domain	NN
cord-259603-bh198xgl	335	13	exhibits	exhibit	VBZ
cord-259603-bh198xgl	335	14	a	a	DT
cord-259603-bh198xgl	335	15	specific	specific	JJ
cord-259603-bh198xgl	335	16	,	,	,
cord-259603-bh198xgl	335	17	Mn	Mn	NNP
cord-259603-bh198xgl	335	18	2	2	CD
cord-259603-bh198xgl	335	19	+	+	SYM
cord-259603-bh198xgl	335	20	-dependent	-dependent	JJ
cord-259603-bh198xgl	335	21	enzymatic	enzymatic	JJ
cord-259603-bh198xgl	335	22	activity	activity	NN
cord-259603-bh198xgl	335	23	that	that	WDT
cord-259603-bh198xgl	335	24	results	result	VBZ
cord-259603-bh198xgl	335	25	in	in	IN
cord-259603-bh198xgl	335	26	the	the	DT
cord-259603-bh198xgl	335	27	self	self	NN
cord-259603-bh198xgl	335	28	-	-	HYPH
cord-259603-bh198xgl	335	29	nucleotidylation	nucleotidylation	NN
cord-259603-bh198xgl	335	30	of	of	IN
cord-259603-bh198xgl	335	31	EAV	EAV	NNP
cord-259603-bh198xgl	335	32	nsp9	nsp9	NNP
cord-259603-bh198xgl	335	33	.	.	.
cord-259603-bh198xgl	336	1	The	the	DT
cord-259603-bh198xgl	336	2	activity	activity	NN
cord-259603-bh198xgl	336	3	was	be	VBD
cord-259603-bh198xgl	336	4	abolished	abolish	VBN
cord-259603-bh198xgl	336	5	upon	upon	IN
cord-259603-bh198xgl	336	6	mutagenesis	mutagenesis	NN
cord-259603-bh198xgl	336	7	of	of	IN
cord-259603-bh198xgl	336	8	conserved	conserved	JJ
cord-259603-bh198xgl	336	9	key	key	JJ
cord-259603-bh198xgl	336	10	residues	residue	NNS
cord-259603-bh198xgl	336	11	in	in	IN
cord-259603-bh198xgl	336	12	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	336	13	motifs	motif	NNS
cord-259603-bh198xgl	336	14	A	a	NN
cord-259603-bh198xgl	336	15	,	,	,
cord-259603-bh198xgl	336	16	B	b	NN
cord-259603-bh198xgl	336	17	,	,	,
cord-259603-bh198xgl	336	18	and	and	CC
cord-259603-bh198xgl	336	19	C.	C.	NNP
cord-259603-bh198xgl	336	20	Although	Although	NNP
cord-259603-bh198xgl	336	21	UTP	UTP	NNP
cord-259603-bh198xgl	336	22	was	be	VBD
cord-259603-bh198xgl	336	23	found	find	VBN
cord-259603-bh198xgl	336	24	to	to	TO
cord-259603-bh198xgl	336	25	be	be	VB
cord-259603-bh198xgl	336	26	the	the	DT
cord-259603-bh198xgl	336	27	preferred	preferred	JJ
cord-259603-bh198xgl	336	28	substrate	substrate	NN
cord-259603-bh198xgl	336	29	for	for	IN
cord-259603-bh198xgl	336	30	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	336	31	's	's	POS
cord-259603-bh198xgl	336	32	in	in	FW
cord-259603-bh198xgl	336	33	vitro	vitro	FW
cord-259603-bh198xgl	336	34	nucleotidylation	nucleotidylation	NN
cord-259603-bh198xgl	336	35	activity	activity	NN
cord-259603-bh198xgl	336	36	,	,	,
cord-259603-bh198xgl	336	37	also	also	RB
cord-259603-bh198xgl	336	38	GTP	GTP	NNP
cord-259603-bh198xgl	336	39	could	could	MD
cord-259603-bh198xgl	336	40	be	be	VB
cord-259603-bh198xgl	336	41	used	use	VBN
cord-259603-bh198xgl	336	42	,	,	,
cord-259603-bh198xgl	336	43	albeit	albeit	IN
cord-259603-bh198xgl	336	44	less	less	RBR
cord-259603-bh198xgl	336	45	efficiently	efficiently	RB
cord-259603-bh198xgl	336	46	.	.	.
cord-259603-bh198xgl	337	1	The	the	DT
cord-259603-bh198xgl	337	2	conserved	conserved	JJ
cord-259603-bh198xgl	337	3	lysine	lysine	NN
cord-259603-bh198xgl	337	4	residue	residue	NN
cord-259603-bh198xgl	337	5	in	in	IN
cord-259603-bh198xgl	338	1	motif	motif	NN
cord-259603-bh198xgl	338	2	A	a	NN
cord-259603-bh198xgl	339	1	(	(	-LRB-
cord-259603-bh198xgl	339	2	the	the	DT
cord-259603-bh198xgl	339	3	EAV	EAV	NNP
cord-259603-bh198xgl	339	4	equivalent	equivalent	NN
cord-259603-bh198xgl	339	5	of	of	IN
cord-259603-bh198xgl	339	6	Lys-73	Lys-73	NNP
cord-259603-bh198xgl	339	7	in	in	IN
cord-259603-bh198xgl	339	8	SARS	SARS	NNP
cord-259603-bh198xgl	339	9	-	-	HYPH
cord-259603-bh198xgl	339	10	CoV	CoV	NNP
cord-259603-bh198xgl	339	11	nsp12	nsp12	CD
cord-259603-bh198xgl	339	12	)	)	-RRB-
cord-259603-bh198xgl	339	13	was	be	VBD
cord-259603-bh198xgl	339	14	concluded	conclude	VBN
cord-259603-bh198xgl	339	15	to	to	TO
cord-259603-bh198xgl	339	16	be	be	VB
cord-259603-bh198xgl	339	17	the	the	DT
cord-259603-bh198xgl	339	18	most	most	RBS
cord-259603-bh198xgl	339	19	likely	likely	JJ
cord-259603-bh198xgl	339	20	target	target	NN
cord-259603-bh198xgl	339	21	residue	residue	NN
cord-259603-bh198xgl	339	22	for	for	IN
cord-259603-bh198xgl	339	23	nucleotidylation	nucleotidylation	NN
cord-259603-bh198xgl	339	24	via	via	IN
cord-259603-bh198xgl	339	25	formation	formation	NN
cord-259603-bh198xgl	339	26	of	of	IN
cord-259603-bh198xgl	339	27	a	a	DT
cord-259603-bh198xgl	339	28	phosphoamide	phosphoamide	JJ
cord-259603-bh198xgl	339	29	bond	bond	NN
cord-259603-bh198xgl	339	30	.	.	.
cord-259603-bh198xgl	340	1	Although	although	IN
cord-259603-bh198xgl	340	2	the	the	DT
cord-259603-bh198xgl	340	3	importance	importance	NN
cord-259603-bh198xgl	340	4	of	of	IN
cord-259603-bh198xgl	340	5	the	the	DT
cord-259603-bh198xgl	340	6	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	340	7	domains	domain	NNS
cord-259603-bh198xgl	340	8	of	of	IN
cord-259603-bh198xgl	340	9	arterivirus	arterivirus	NNP
cord-259603-bh198xgl	340	10	nsp9	nsp9	NNP
cord-259603-bh198xgl	340	11	and	and	CC
cord-259603-bh198xgl	340	12	coronavirus	coronavirus	NN
cord-259603-bh198xgl	340	13	nps12	nps12	NNS
cord-259603-bh198xgl	340	14	was	be	VBD
cord-259603-bh198xgl	340	15	supported	support	VBN
cord-259603-bh198xgl	340	16	by	by	IN
cord-259603-bh198xgl	340	17	the	the	DT
cord-259603-bh198xgl	340	18	outcome	outcome	NN
cord-259603-bh198xgl	340	19	of	of	IN
cord-259603-bh198xgl	340	20	reverse	reverse	JJ
cord-259603-bh198xgl	340	21	-	-	HYPH
cord-259603-bh198xgl	340	22	genetics	genetics	NN
cord-259603-bh198xgl	340	23	studies	study	NNS
cord-259603-bh198xgl	340	24	(	(	-LRB-
cord-259603-bh198xgl	340	25	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	340	26	et	et	NNP
cord-259603-bh198xgl	340	27	al	al	NNP
cord-259603-bh198xgl	340	28	.	.	NNP
cord-259603-bh198xgl	340	29	,	,	,
cord-259603-bh198xgl	340	30	2015a	2015a	CD
cord-259603-bh198xgl	340	31	)	)	-RRB-
cord-259603-bh198xgl	340	32	,	,	,
cord-259603-bh198xgl	340	33	the	the	DT
cord-259603-bh198xgl	340	34	role	role	NN
cord-259603-bh198xgl	340	35	of	of	IN
cord-259603-bh198xgl	340	36	the	the	DT
cord-259603-bh198xgl	340	37	produced	produce	VBN
cord-259603-bh198xgl	340	38	protein	protein	NN
cord-259603-bh198xgl	340	39	-	-	HYPH
cord-259603-bh198xgl	340	40	nucleoside	nucleoside	NN
cord-259603-bh198xgl	340	41	adducts	adduct	NNS
cord-259603-bh198xgl	340	42	in	in	IN
cord-259603-bh198xgl	340	43	viral	viral	JJ
cord-259603-bh198xgl	340	44	replication	replication	NN
cord-259603-bh198xgl	340	45	remains	remain	VBZ
cord-259603-bh198xgl	340	46	unclear	unclear	JJ
cord-259603-bh198xgl	340	47	at	at	IN
cord-259603-bh198xgl	340	48	present	present	NN
cord-259603-bh198xgl	340	49	.	.	.
cord-259603-bh198xgl	341	1	In	in	IN
cord-259603-bh198xgl	341	2	fact	fact	NN
cord-259603-bh198xgl	341	3	,	,	,
cord-259603-bh198xgl	341	4	the	the	DT
cord-259603-bh198xgl	341	5	unique	unique	JJ
cord-259603-bh198xgl	341	6	dual	dual	JJ
cord-259603-bh198xgl	341	7	specificity	specificity	NN
cord-259603-bh198xgl	341	8	for	for	IN
cord-259603-bh198xgl	341	9	UTP	UTP	NNP
cord-259603-bh198xgl	341	10	and	and	CC
cord-259603-bh198xgl	341	11	GTP	GTP	NNP
cord-259603-bh198xgl	341	12	seems	seem	VBZ
cord-259603-bh198xgl	341	13	to	to	TO
cord-259603-bh198xgl	341	14	argue	argue	VB
cord-259603-bh198xgl	341	15	against	against	IN
cord-259603-bh198xgl	341	16	two	two	CD
cord-259603-bh198xgl	341	17	initially	initially	RB
cord-259603-bh198xgl	341	18	considered	consider	VBN
cord-259603-bh198xgl	341	19	potential	potential	JJ
cord-259603-bh198xgl	341	20	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	341	21	functions	function	NNS
cord-259603-bh198xgl	341	22	(	(	-LRB-
cord-259603-bh198xgl	341	23	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	341	24	et	et	NNP
cord-259603-bh198xgl	341	25	al	al	NNP
cord-259603-bh198xgl	341	26	.	.	NNP
cord-259603-bh198xgl	341	27	,	,	,
cord-259603-bh198xgl	341	28	2015a	2015a	CD
cord-259603-bh198xgl	341	29	)	)	-RRB-
cord-259603-bh198xgl	341	30	.	.	.
cord-259603-bh198xgl	342	1	The	the	DT
cord-259603-bh198xgl	342	2	first	first	JJ
cord-259603-bh198xgl	342	3	of	of	IN
cord-259603-bh198xgl	342	4	these	these	DT
cord-259603-bh198xgl	342	5	was	be	VBD
cord-259603-bh198xgl	342	6	a	a	DT
cord-259603-bh198xgl	342	7	role	role	NN
cord-259603-bh198xgl	342	8	as	as	IN
cord-259603-bh198xgl	342	9	an	an	DT
cord-259603-bh198xgl	342	10	RNA	RNA	NNP
cord-259603-bh198xgl	342	11	ligase	ligase	NN
cord-259603-bh198xgl	342	12	,	,	,
cord-259603-bh198xgl	342	13	a	a	DT
cord-259603-bh198xgl	342	14	type	type	NN
cord-259603-bh198xgl	342	15	of	of	IN
cord-259603-bh198xgl	342	16	activity	activity	NN
cord-259603-bh198xgl	342	17	however	however	RB
cord-259603-bh198xgl	342	18	that	that	WDT
cord-259603-bh198xgl	342	19	commonly	commonly	RB
cord-259603-bh198xgl	342	20	is	be	VBZ
cord-259603-bh198xgl	342	21	ATP	ATP	NNP
cord-259603-bh198xgl	342	22	dependent	dependent	JJ
cord-259603-bh198xgl	342	23	.	.	.
cord-259603-bh198xgl	343	1	The	the	DT
cord-259603-bh198xgl	343	2	second	second	JJ
cord-259603-bh198xgl	343	3	was	be	VBD
cord-259603-bh198xgl	343	4	its	-PRON-	PRP$
cord-259603-bh198xgl	343	5	involvement	involvement	NN
cord-259603-bh198xgl	343	6	in	in	IN
cord-259603-bh198xgl	343	7	synthesizing	synthesize	VBG
cord-259603-bh198xgl	343	8	mRNA	mRNA	NNP
cord-259603-bh198xgl	343	9	cap	cap	NN
cord-259603-bh198xgl	343	10	structures	structure	NNS
cord-259603-bh198xgl	343	11	.	.	.
cord-259603-bh198xgl	344	1	One	one	CD
cord-259603-bh198xgl	344	2	of	of	IN
cord-259603-bh198xgl	344	3	the	the	DT
cord-259603-bh198xgl	344	4	four	four	CD
cord-259603-bh198xgl	344	5	enzymes	enzyme	NNS
cord-259603-bh198xgl	344	6	required	require	VBN
cord-259603-bh198xgl	344	7	for	for	IN
cord-259603-bh198xgl	344	8	this	this	DT
cord-259603-bh198xgl	344	9	process	process	NN
cord-259603-bh198xgl	344	10	,	,	,
cord-259603-bh198xgl	344	11	the	the	DT
cord-259603-bh198xgl	344	12	crucial	crucial	JJ
cord-259603-bh198xgl	344	13	guanylyl	guanylyl	JJ
cord-259603-bh198xgl	344	14	transferase	transferase	NN
cord-259603-bh198xgl	344	15	(	(	-LRB-
cord-259603-bh198xgl	344	16	GTase	GTase	NNP
cord-259603-bh198xgl	344	17	)	)	-RRB-
cord-259603-bh198xgl	344	18	,	,	,
cord-259603-bh198xgl	344	19	still	still	RB
cord-259603-bh198xgl	344	20	remains	remain	VBZ
cord-259603-bh198xgl	344	21	to	to	TO
cord-259603-bh198xgl	344	22	be	be	VB
cord-259603-bh198xgl	344	23	identified	identify	VBN
cord-259603-bh198xgl	344	24	for	for	IN
cord-259603-bh198xgl	344	25	CoVs	CoVs	NNP
cord-259603-bh198xgl	344	26	(	(	-LRB-
cord-259603-bh198xgl	344	27	see	see	VB
cord-259603-bh198xgl	344	28	later	later	RB
cord-259603-bh198xgl	344	29	)	)	-RRB-
cord-259603-bh198xgl	344	30	.	.	.
cord-259603-bh198xgl	345	1	However	however	RB
cord-259603-bh198xgl	345	2	,	,	,
cord-259603-bh198xgl	345	3	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	345	4	's	's	POS
cord-259603-bh198xgl	345	5	substrate	substrate	JJ
cord-259603-bh198xgl	345	6	preference	preference	NN
cord-259603-bh198xgl	345	7	for	for	IN
cord-259603-bh198xgl	345	8	UTP	UTP	NNP
cord-259603-bh198xgl	345	9	over	over	IN
cord-259603-bh198xgl	345	10	GTP	GTP	NNP
cord-259603-bh198xgl	345	11	is	be	VBZ
cord-259603-bh198xgl	345	12	difficult	difficult	JJ
cord-259603-bh198xgl	345	13	to	to	TO
cord-259603-bh198xgl	345	14	reconcile	reconcile	VB
cord-259603-bh198xgl	345	15	with	with	IN
cord-259603-bh198xgl	345	16	this	this	DT
cord-259603-bh198xgl	345	17	hypothesis	hypothesis	NN
cord-259603-bh198xgl	345	18	and	and	CC
cord-259603-bh198xgl	345	19	has	have	VBZ
cord-259603-bh198xgl	345	20	not	not	RB
cord-259603-bh198xgl	345	21	been	be	VBN
cord-259603-bh198xgl	345	22	observed	observe	VBN
cord-259603-bh198xgl	345	23	for	for	IN
cord-259603-bh198xgl	345	24	other	other	JJ
cord-259603-bh198xgl	345	25	GTases	GTases	NNPS
cord-259603-bh198xgl	345	26	involved	involve	VBN
cord-259603-bh198xgl	345	27	in	in	IN
cord-259603-bh198xgl	345	28	mRNA	mrna	NN
cord-259603-bh198xgl	345	29	capping	capping	NN
cord-259603-bh198xgl	345	30	.	.	.
cord-259603-bh198xgl	346	1	The	the	DT
cord-259603-bh198xgl	346	2	third	third	JJ
cord-259603-bh198xgl	346	3	hypothesis	hypothesis	NN
cord-259603-bh198xgl	346	4	that	that	WDT
cord-259603-bh198xgl	346	5	was	be	VBD
cord-259603-bh198xgl	346	6	put	put	VBN
cord-259603-bh198xgl	346	7	forward	forward	RP
cord-259603-bh198xgl	346	8	links	link	NNS
cord-259603-bh198xgl	346	9	back	back	RB
cord-259603-bh198xgl	346	10	to	to	IN
cord-259603-bh198xgl	346	11	the	the	DT
cord-259603-bh198xgl	346	12	open	open	JJ
cord-259603-bh198xgl	346	13	question	question	NN
cord-259603-bh198xgl	346	14	of	of	IN
cord-259603-bh198xgl	346	15	the	the	DT
cord-259603-bh198xgl	346	16	initiation	initiation	NN
cord-259603-bh198xgl	346	17	of	of	IN
cord-259603-bh198xgl	346	18	coronavirus	coronavirus	NN
cord-259603-bh198xgl	346	19	RNA	RNA	NNP
cord-259603-bh198xgl	346	20	synthesis	synthesis	NN
cord-259603-bh198xgl	346	21	,	,	,
cord-259603-bh198xgl	346	22	which	which	WDT
cord-259603-bh198xgl	346	23	presumably	presumably	RB
cord-259603-bh198xgl	346	24	is	be	VBZ
cord-259603-bh198xgl	346	25	a	a	DT
cord-259603-bh198xgl	346	26	primer	primer	NN
cord-259603-bh198xgl	346	27	-	-	HYPH
cord-259603-bh198xgl	346	28	dependent	dependent	JJ
cord-259603-bh198xgl	346	29	step	step	NN
cord-259603-bh198xgl	346	30	(	(	-LRB-
cord-259603-bh198xgl	346	31	see	see	VB
cord-259603-bh198xgl	346	32	earlier	early	RBR
cord-259603-bh198xgl	346	33	)	)	-RRB-
cord-259603-bh198xgl	346	34	.	.	.
cord-259603-bh198xgl	347	1	Nsp12	Nsp12	NNP
cord-259603-bh198xgl	347	2	nucleotidylation	nucleotidylation	NN
cord-259603-bh198xgl	347	3	could	could	MD
cord-259603-bh198xgl	347	4	be	be	VB
cord-259603-bh198xgl	347	5	envisioned	envision	VBN
cord-259603-bh198xgl	347	6	to	to	TO
cord-259603-bh198xgl	347	7	play	play	VB
cord-259603-bh198xgl	347	8	a	a	DT
cord-259603-bh198xgl	347	9	role	role	NN
cord-259603-bh198xgl	347	10	in	in	IN
cord-259603-bh198xgl	347	11	protein	protein	NN
cord-259603-bh198xgl	347	12	-	-	HYPH
cord-259603-bh198xgl	347	13	primed	prime	VBN
cord-259603-bh198xgl	347	14	RNA	RNA	NNP
cord-259603-bh198xgl	347	15	synthesis	synthesis	NN
cord-259603-bh198xgl	347	16	,	,	,
cord-259603-bh198xgl	347	17	a	a	DT
cord-259603-bh198xgl	347	18	strategy	strategy	NN
cord-259603-bh198xgl	347	19	used	use	VBN
cord-259603-bh198xgl	347	20	by	by	IN
cord-259603-bh198xgl	347	21	,	,	,
cord-259603-bh198xgl	347	22	e.g.	e.g.	RB
cord-259603-bh198xgl	347	23	,	,	,
cord-259603-bh198xgl	347	24	picornaviruses	picornavirus	NNS
cord-259603-bh198xgl	347	25	and	and	CC
cord-259603-bh198xgl	347	26	their	-PRON-	PRP$
cord-259603-bh198xgl	347	27	relatives	relative	NNS
cord-259603-bh198xgl	347	28	,	,	,
cord-259603-bh198xgl	347	29	which	which	WDT
cord-259603-bh198xgl	347	30	covalently	covalently	RB
cord-259603-bh198xgl	347	31	attach	attach	VBP
cord-259603-bh198xgl	347	32	an	an	DT
cord-259603-bh198xgl	347	33	oligonucleotide	oligonucleotide	NN
cord-259603-bh198xgl	347	34	to	to	IN
cord-259603-bh198xgl	347	35	a	a	DT
cord-259603-bh198xgl	347	36	viral	viral	JJ
cord-259603-bh198xgl	347	37	protein	protein	NN
cord-259603-bh198xgl	347	38	(	(	-LRB-
cord-259603-bh198xgl	347	39	called	call	VBN
cord-259603-bh198xgl	347	40	VPg	VPg	NNS
cord-259603-bh198xgl	347	41	in	in	IN
cord-259603-bh198xgl	347	42	the	the	DT
cord-259603-bh198xgl	347	43	case	case	NN
cord-259603-bh198xgl	347	44	of	of	IN
cord-259603-bh198xgl	347	45	picornaviruses	picornavirus	NNS
cord-259603-bh198xgl	347	46	)	)	-RRB-
cord-259603-bh198xgl	347	47	that	that	WDT
cord-259603-bh198xgl	347	48	subsequently	subsequently	RB
cord-259603-bh198xgl	347	49	mediates	mediate	VBZ
cord-259603-bh198xgl	347	50	the	the	DT
cord-259603-bh198xgl	347	51	initiation	initiation	NN
cord-259603-bh198xgl	347	52	of	of	IN
cord-259603-bh198xgl	347	53	RNA	RNA	NNP
cord-259603-bh198xgl	347	54	synthesis	synthesis	NN
cord-259603-bh198xgl	348	1	(	(	-LRB-
cord-259603-bh198xgl	348	2	Paul	Paul	NNP
cord-259603-bh198xgl	348	3	et	et	NNP
cord-259603-bh198xgl	348	4	al	al	NNP
cord-259603-bh198xgl	348	5	.	.	NNP
cord-259603-bh198xgl	348	6	,	,	,
cord-259603-bh198xgl	348	7	2000	2000	CD
cord-259603-bh198xgl	348	8	)	)	-RRB-
cord-259603-bh198xgl	348	9	.	.	.
cord-259603-bh198xgl	349	1	The	the	DT
cord-259603-bh198xgl	349	2	first	first	JJ
cord-259603-bh198xgl	349	3	step	step	NN
cord-259603-bh198xgl	349	4	in	in	IN
cord-259603-bh198xgl	349	5	the	the	DT
cord-259603-bh198xgl	349	6	synthesis	synthesis	NN
cord-259603-bh198xgl	349	7	of	of	IN
cord-259603-bh198xgl	349	8	the	the	DT
cord-259603-bh198xgl	349	9	"	"	``
cord-259603-bh198xgl	349	10	protein	protein	NN
cord-259603-bh198xgl	349	11	primer	primer	NN
cord-259603-bh198xgl	349	12	"	"	''
cord-259603-bh198xgl	349	13	is	be	VBZ
cord-259603-bh198xgl	349	14	a	a	DT
cord-259603-bh198xgl	349	15	nucleotidylation	nucleotidylation	NN
cord-259603-bh198xgl	349	16	step	step	NN
cord-259603-bh198xgl	349	17	during	during	IN
cord-259603-bh198xgl	349	18	which	which	WDT
cord-259603-bh198xgl	349	19	a	a	DT
cord-259603-bh198xgl	349	20	nucleotide	nucleotide	JJ
cord-259603-bh198xgl	349	21	monophosphate	monophosphate	NN
cord-259603-bh198xgl	349	22	is	be	VBZ
cord-259603-bh198xgl	349	23	covalently	covalently	RB
cord-259603-bh198xgl	349	24	attached	attach	VBN
cord-259603-bh198xgl	349	25	to	to	IN
cord-259603-bh198xgl	349	26	the	the	DT
cord-259603-bh198xgl	349	27	VPg	VPg	NNS
cord-259603-bh198xgl	349	28	.	.	.
cord-259603-bh198xgl	350	1	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	350	2	could	could	MD
cord-259603-bh198xgl	350	3	be	be	VB
cord-259603-bh198xgl	350	4	involved	involve	VBN
cord-259603-bh198xgl	350	5	in	in	IN
cord-259603-bh198xgl	350	6	a	a	DT
cord-259603-bh198xgl	350	7	similar	similar	JJ
cord-259603-bh198xgl	350	8	mechanism	mechanism	NN
cord-259603-bh198xgl	350	9	either	either	CC
cord-259603-bh198xgl	350	10	directly	directly	RB
cord-259603-bh198xgl	350	11	or	or	CC
cord-259603-bh198xgl	350	12	indirectly	indirectly	RB
cord-259603-bh198xgl	350	13	,	,	,
cord-259603-bh198xgl	350	14	by	by	IN
cord-259603-bh198xgl	350	15	transferring	transfer	VBG
cord-259603-bh198xgl	350	16	the	the	DT
cord-259603-bh198xgl	350	17	bound	bind	VBN
cord-259603-bh198xgl	350	18	nucleotide	nucleotide	JJ
cord-259603-bh198xgl	350	19	to	to	IN
cord-259603-bh198xgl	350	20	another	another	DT
cord-259603-bh198xgl	350	21	protein	protein	NN
cord-259603-bh198xgl	350	22	player	player	NN
cord-259603-bh198xgl	350	23	.	.	.
cord-259603-bh198xgl	351	1	Although	although	IN
cord-259603-bh198xgl	351	2	such	such	JJ
cord-259603-bh198xgl	351	3	a	a	DT
cord-259603-bh198xgl	351	4	mechanism	mechanism	NN
cord-259603-bh198xgl	351	5	would	would	MD
cord-259603-bh198xgl	351	6	definitely	definitely	RB
cord-259603-bh198xgl	351	7	revolutionize	revolutionize	VB
cord-259603-bh198xgl	351	8	the	the	DT
cord-259603-bh198xgl	351	9	concept	concept	NN
cord-259603-bh198xgl	351	10	of	of	IN
cord-259603-bh198xgl	351	11	the	the	DT
cord-259603-bh198xgl	351	12	initiation	initiation	NN
cord-259603-bh198xgl	351	13	of	of	IN
cord-259603-bh198xgl	351	14	CoV	CoV	NNP
cord-259603-bh198xgl	351	15	RNA	RNA	NNP
cord-259603-bh198xgl	351	16	synthesis	synthesis	NN
cord-259603-bh198xgl	351	17	,	,	,
cord-259603-bh198xgl	351	18	it	-PRON-	PRP
cord-259603-bh198xgl	351	19	is	be	VBZ
cord-259603-bh198xgl	351	20	clearly	clearly	RB
cord-259603-bh198xgl	351	21	not	not	RB
cord-259603-bh198xgl	351	22	very	very	RB
cord-259603-bh198xgl	351	23	compatible	compatible	JJ
cord-259603-bh198xgl	351	24	with	with	IN
cord-259603-bh198xgl	351	25	some	some	DT
cord-259603-bh198xgl	351	26	of	of	IN
cord-259603-bh198xgl	351	27	the	the	DT
cord-259603-bh198xgl	351	28	currently	currently	RB
cord-259603-bh198xgl	351	29	available	available	JJ
cord-259603-bh198xgl	351	30	data	datum	NNS
cord-259603-bh198xgl	351	31	,	,	,
cord-259603-bh198xgl	351	32	such	such	JJ
cord-259603-bh198xgl	351	33	as	as	IN
cord-259603-bh198xgl	351	34	the	the	DT
cord-259603-bh198xgl	351	35	reported	report	VBN
cord-259603-bh198xgl	351	36	presence	presence	NN
cord-259603-bh198xgl	351	37	of	of	IN
cord-259603-bh198xgl	351	38	a	a	DT
cord-259603-bh198xgl	351	39	5	5	CD
cord-259603-bh198xgl	351	40	0	0	CD
cord-259603-bh198xgl	351	41	cap	cap	NN
cord-259603-bh198xgl	351	42	structure	structure	NN
cord-259603-bh198xgl	351	43	(	(	-LRB-
cord-259603-bh198xgl	351	44	rather	rather	RB
cord-259603-bh198xgl	351	45	than	than	IN
cord-259603-bh198xgl	351	46	a	a	DT
cord-259603-bh198xgl	351	47	VPg	vpg	NN
cord-259603-bh198xgl	351	48	-	-	HYPH
cord-259603-bh198xgl	351	49	like	like	JJ
cord-259603-bh198xgl	351	50	molecule	molecule	NN
cord-259603-bh198xgl	351	51	)	)	-RRB-
cord-259603-bh198xgl	351	52	on	on	IN
cord-259603-bh198xgl	351	53	CoV	CoV	NNP
cord-259603-bh198xgl	351	54	mRNAs	mrnas	CD
cord-259603-bh198xgl	351	55	.	.	.
cord-259603-bh198xgl	352	1	Evidently	evidently	RB
cord-259603-bh198xgl	352	2	,	,	,
cord-259603-bh198xgl	352	3	the	the	DT
cord-259603-bh198xgl	352	4	further	far	RBR
cord-259603-bh198xgl	352	5	in	in	IN
cord-259603-bh198xgl	352	6	-	-	HYPH
cord-259603-bh198xgl	352	7	depth	depth	NN
cord-259603-bh198xgl	352	8	characterization	characterization	NN
cord-259603-bh198xgl	352	9	of	of	IN
cord-259603-bh198xgl	352	10	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	352	11	is	be	VBZ
cord-259603-bh198xgl	352	12	needed	need	VBN
cord-259603-bh198xgl	352	13	to	to	TO
cord-259603-bh198xgl	352	14	fill	fill	VB
cord-259603-bh198xgl	352	15	the	the	DT
cord-259603-bh198xgl	352	16	current	current	JJ
cord-259603-bh198xgl	352	17	knowledge	knowledge	NN
cord-259603-bh198xgl	352	18	gaps	gap	NNS
cord-259603-bh198xgl	352	19	,	,	,
cord-259603-bh198xgl	352	20	starting	start	VBG
cord-259603-bh198xgl	352	21	with	with	IN
cord-259603-bh198xgl	352	22	the	the	DT
cord-259603-bh198xgl	352	23	biochemical	biochemical	JJ
cord-259603-bh198xgl	352	24	characterization	characterization	NN
cord-259603-bh198xgl	352	25	of	of	IN
cord-259603-bh198xgl	352	26	a	a	DT
cord-259603-bh198xgl	352	27	CoV	cov	NN
cord-259603-bh198xgl	352	28	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	352	29	domain	domain	NN
cord-259603-bh198xgl	352	30	,	,	,
cord-259603-bh198xgl	352	31	which	which	WDT
cord-259603-bh198xgl	352	32	may	may	MD
cord-259603-bh198xgl	352	33	confirm	confirm	VB
cord-259603-bh198xgl	352	34	and	and	CC
cord-259603-bh198xgl	352	35	extend	extend	VB
cord-259603-bh198xgl	352	36	the	the	DT
cord-259603-bh198xgl	352	37	features	feature	NNS
cord-259603-bh198xgl	352	38	now	now	RB
cord-259603-bh198xgl	352	39	deduced	deduce	VBN
cord-259603-bh198xgl	352	40	from	from	IN
cord-259603-bh198xgl	352	41	the	the	DT
cord-259603-bh198xgl	352	42	analysis	analysis	NN
cord-259603-bh198xgl	352	43	of	of	IN
cord-259603-bh198xgl	352	44	its	-PRON-	PRP$
cord-259603-bh198xgl	352	45	distantly	distantly	RB
cord-259603-bh198xgl	352	46	related	relate	VBN
cord-259603-bh198xgl	352	47	arterivirus	arterivirus	NN
cord-259603-bh198xgl	352	48	homolog	homolog	NN
cord-259603-bh198xgl	352	49	.	.	.
cord-259603-bh198xgl	353	1	Helicases	Helicases	NNP
cord-259603-bh198xgl	353	2	are	be	VBP
cord-259603-bh198xgl	353	3	versatile	versatile	JJ
cord-259603-bh198xgl	353	4	NTP	ntp	NN
cord-259603-bh198xgl	353	5	-	-	HYPH
cord-259603-bh198xgl	353	6	dependent	dependent	JJ
cord-259603-bh198xgl	353	7	motor	motor	NN
cord-259603-bh198xgl	353	8	proteins	protein	NNS
cord-259603-bh198xgl	353	9	that	that	WDT
cord-259603-bh198xgl	353	10	play	play	VBP
cord-259603-bh198xgl	353	11	a	a	DT
cord-259603-bh198xgl	353	12	role	role	NN
cord-259603-bh198xgl	353	13	in	in	IN
cord-259603-bh198xgl	353	14	cellular	cellular	JJ
cord-259603-bh198xgl	353	15	nucleic	nucleic	JJ
cord-259603-bh198xgl	353	16	acid	acid	NN
cord-259603-bh198xgl	353	17	metabolism	metabolism	NN
cord-259603-bh198xgl	353	18	in	in	IN
cord-259603-bh198xgl	353	19	the	the	DT
cord-259603-bh198xgl	353	20	broadest	broad	JJS
cord-259603-bh198xgl	353	21	possible	possible	JJ
cord-259603-bh198xgl	353	22	sense	sense	NN
cord-259603-bh198xgl	353	23	,	,	,
cord-259603-bh198xgl	353	24	including	include	VBG
cord-259603-bh198xgl	353	25	processes	process	NNS
cord-259603-bh198xgl	353	26	like	like	IN
cord-259603-bh198xgl	353	27	DNA	dna	NN
cord-259603-bh198xgl	353	28	replication	replication	NN
cord-259603-bh198xgl	353	29	,	,	,
cord-259603-bh198xgl	353	30	recombination	recombination	NN
cord-259603-bh198xgl	353	31	and	and	CC
cord-259603-bh198xgl	353	32	repair	repair	NN
cord-259603-bh198xgl	353	33	,	,	,
cord-259603-bh198xgl	353	34	transcription	transcription	NN
cord-259603-bh198xgl	353	35	,	,	,
cord-259603-bh198xgl	353	36	translation	translation	NN
cord-259603-bh198xgl	353	37	,	,	,
cord-259603-bh198xgl	353	38	as	as	RB
cord-259603-bh198xgl	353	39	well	well	RB
cord-259603-bh198xgl	353	40	as	as	IN
cord-259603-bh198xgl	353	41	RNA	rna	NN
cord-259603-bh198xgl	353	42	processing	processing	NN
cord-259603-bh198xgl	353	43	.	.	.
cord-259603-bh198xgl	354	1	Helicases	Helicases	NNP
cord-259603-bh198xgl	354	2	are	be	VBP
cord-259603-bh198xgl	354	3	also	also	RB
cord-259603-bh198xgl	354	4	encoded	encode	VBN
cord-259603-bh198xgl	354	5	by	by	IN
cord-259603-bh198xgl	354	6	all	all	DT
cord-259603-bh198xgl	354	7	+	+	SYM
cord-259603-bh198xgl	354	8	RNA	rna	NN
cord-259603-bh198xgl	354	9	viruses	virus	NNS
cord-259603-bh198xgl	354	10	with	with	IN
cord-259603-bh198xgl	354	11	a	a	DT
cord-259603-bh198xgl	354	12	genome	genome	NN
cord-259603-bh198xgl	354	13	size	size	NN
cord-259603-bh198xgl	354	14	exceeding	exceed	VBG
cord-259603-bh198xgl	354	15	7	7	CD
cord-259603-bh198xgl	354	16	kb	kb	NNP
cord-259603-bh198xgl	354	17	,	,	,
cord-259603-bh198xgl	354	18	suggesting	suggest	VBG
cord-259603-bh198xgl	354	19	they	-PRON-	PRP
cord-259603-bh198xgl	354	20	are	be	VBP
cord-259603-bh198xgl	354	21	required	require	VBN
cord-259603-bh198xgl	354	22	for	for	IN
cord-259603-bh198xgl	354	23	the	the	DT
cord-259603-bh198xgl	354	24	efficient	efficient	JJ
cord-259603-bh198xgl	354	25	replication	replication	NN
cord-259603-bh198xgl	354	26	of	of	IN
cord-259603-bh198xgl	354	27	+	+	SYM
cord-259603-bh198xgl	354	28	RNA	rna	NN
cord-259603-bh198xgl	354	29	viral	viral	JJ
cord-259603-bh198xgl	354	30	genomes	genome	NNS
cord-259603-bh198xgl	354	31	above	above	IN
cord-259603-bh198xgl	354	32	this	this	DT
cord-259603-bh198xgl	354	33	size	size	NN
cord-259603-bh198xgl	354	34	threshold	threshold	NN
cord-259603-bh198xgl	354	35	.	.	.
cord-259603-bh198xgl	355	1	Given	give	VBN
cord-259603-bh198xgl	355	2	the	the	DT
cord-259603-bh198xgl	355	3	large	large	JJ
cord-259603-bh198xgl	355	4	size	size	NN
cord-259603-bh198xgl	355	5	of	of	IN
cord-259603-bh198xgl	355	6	the	the	DT
cord-259603-bh198xgl	355	7	genomes	genome	NNS
cord-259603-bh198xgl	355	8	of	of	IN
cord-259603-bh198xgl	355	9	CoVs	CoVs	NNP
cord-259603-bh198xgl	355	10	and	and	CC
cord-259603-bh198xgl	355	11	related	relate	VBN
cord-259603-bh198xgl	355	12	nidoviruses	nidoviruse	NNS
cord-259603-bh198xgl	355	13	,	,	,
cord-259603-bh198xgl	355	14	they	-PRON-	PRP
cord-259603-bh198xgl	355	15	may	may	MD
cord-259603-bh198xgl	355	16	depend	depend	VB
cord-259603-bh198xgl	355	17	on	on	IN
cord-259603-bh198xgl	355	18	the	the	DT
cord-259603-bh198xgl	355	19	function(s	function(s	NNP
cord-259603-bh198xgl	355	20	)	)	-RRB-
cord-259603-bh198xgl	355	21	of	of	IN
cord-259603-bh198xgl	355	22	a	a	DT
cord-259603-bh198xgl	355	23	replicative	replicative	JJ
cord-259603-bh198xgl	355	24	helicase	helicase	NN
cord-259603-bh198xgl	355	25	even	even	RB
cord-259603-bh198xgl	355	26	more	more	RBR
cord-259603-bh198xgl	355	27	than	than	IN
cord-259603-bh198xgl	355	28	other	other	JJ
cord-259603-bh198xgl	355	29	+	+	CC
cord-259603-bh198xgl	355	30	RNA	rna	NN
cord-259603-bh198xgl	355	31	virus	virus	NN
cord-259603-bh198xgl	355	32	taxa	taxon	NNS
cord-259603-bh198xgl	355	33	.	.	.
cord-259603-bh198xgl	356	1	However	however	RB
cord-259603-bh198xgl	356	2	,	,	,
cord-259603-bh198xgl	356	3	despite	despite	IN
cord-259603-bh198xgl	356	4	their	-PRON-	PRP$
cord-259603-bh198xgl	356	5	abundance	abundance	NN
cord-259603-bh198xgl	356	6	and	and	CC
cord-259603-bh198xgl	356	7	conservation	conservation	NN
cord-259603-bh198xgl	356	8	,	,	,
cord-259603-bh198xgl	356	9	the	the	DT
cord-259603-bh198xgl	356	10	specific	specific	JJ
cord-259603-bh198xgl	356	11	role	role	NN
cord-259603-bh198xgl	356	12	of	of	IN
cord-259603-bh198xgl	356	13	helicases	helicase	NNS
cord-259603-bh198xgl	356	14	in	in	IN
cord-259603-bh198xgl	356	15	+	+	CC
cord-259603-bh198xgl	357	1	RNA	RNA	NNP
cord-259603-bh198xgl	357	2	virus	virus	NN
cord-259603-bh198xgl	357	3	replication	replication	NN
cord-259603-bh198xgl	357	4	remains	remain	VBZ
cord-259603-bh198xgl	357	5	poorly	poorly	RB
cord-259603-bh198xgl	357	6	understood	understand	VBN
cord-259603-bh198xgl	357	7	.	.	.
cord-259603-bh198xgl	358	1	For	for	IN
cord-259603-bh198xgl	358	2	an	an	DT
cord-259603-bh198xgl	358	3	extensive	extensive	JJ
cord-259603-bh198xgl	358	4	recent	recent	JJ
cord-259603-bh198xgl	358	5	review	review	NN
cord-259603-bh198xgl	358	6	of	of	IN
cord-259603-bh198xgl	358	7	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	358	8	helicases	helicases	NNPS
cord-259603-bh198xgl	358	9	,	,	,
cord-259603-bh198xgl	358	10	the	the	DT
cord-259603-bh198xgl	358	11	reader	reader	NN
cord-259603-bh198xgl	358	12	is	be	VBZ
cord-259603-bh198xgl	358	13	referred	refer	VBN
cord-259603-bh198xgl	358	14	to	to	IN
cord-259603-bh198xgl	358	15	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	358	16	et	et	NNP
cord-259603-bh198xgl	358	17	al	al	NNP
cord-259603-bh198xgl	358	18	.	.	.
cord-259603-bh198xgl	359	1	(	(	-LRB-
cord-259603-bh198xgl	359	2	2015c	2015c	CD
cord-259603-bh198xgl	359	3	)	)	-RRB-
cord-259603-bh198xgl	359	4	.	.	.
cord-259603-bh198xgl	360	1	Currently	currently	RB
cord-259603-bh198xgl	360	2	,	,	,
cord-259603-bh198xgl	360	3	helicases	helicase	NNS
cord-259603-bh198xgl	360	4	are	be	VBP
cord-259603-bh198xgl	360	5	classified	classify	VBN
cord-259603-bh198xgl	360	6	into	into	IN
cord-259603-bh198xgl	360	7	six	six	CD
cord-259603-bh198xgl	360	8	superfamilies	superfamily	NNS
cord-259603-bh198xgl	360	9	(	(	-LRB-
cord-259603-bh198xgl	360	10	SFs	SFs	NNP
cord-259603-bh198xgl	360	11	)	)	-RRB-
cord-259603-bh198xgl	360	12	(	(	-LRB-
cord-259603-bh198xgl	360	13	Singleton	Singleton	NNP
cord-259603-bh198xgl	360	14	et	et	FW
cord-259603-bh198xgl	360	15	al	al	NNP
cord-259603-bh198xgl	360	16	.	.	NNP
cord-259603-bh198xgl	360	17	,	,	,
cord-259603-bh198xgl	360	18	2007	2007	CD
cord-259603-bh198xgl	360	19	)	)	-RRB-
cord-259603-bh198xgl	360	20	,	,	,
cord-259603-bh198xgl	360	21	with	with	IN
cord-259603-bh198xgl	360	22	+	+	CC
cord-259603-bh198xgl	360	23	RNA	RNA	NNP
cord-259603-bh198xgl	360	24	viral	viral	JJ
cord-259603-bh198xgl	360	25	helicases	helicase	NNS
cord-259603-bh198xgl	360	26	belonging	belong	VBG
cord-259603-bh198xgl	360	27	to	to	IN
cord-259603-bh198xgl	360	28	SF1	SF1	NNP
cord-259603-bh198xgl	360	29	(	(	-LRB-
cord-259603-bh198xgl	360	30	e.g.	e.g.	RB
cord-259603-bh198xgl	360	31	,	,	,
cord-259603-bh198xgl	360	32	alphaviruses	alphaviruses	NNP
cord-259603-bh198xgl	360	33	and	and	CC
cord-259603-bh198xgl	360	34	nidoviruses	nidoviruses	NNP
cord-259603-bh198xgl	360	35	)	)	-RRB-
cord-259603-bh198xgl	360	36	,	,	,
cord-259603-bh198xgl	360	37	SF2	SF2	NNP
cord-259603-bh198xgl	360	38	(	(	-LRB-
cord-259603-bh198xgl	360	39	e.g.	e.g.	RB
cord-259603-bh198xgl	360	40	,	,	,
cord-259603-bh198xgl	360	41	flaviviruses	flaviviruses	NNP
cord-259603-bh198xgl	360	42	)	)	-RRB-
cord-259603-bh198xgl	360	43	,	,	,
cord-259603-bh198xgl	360	44	or	or	CC
cord-259603-bh198xgl	360	45	SF3	SF3	NNP
cord-259603-bh198xgl	360	46	(	(	-LRB-
cord-259603-bh198xgl	360	47	e.g.	e.g.	RB
cord-259603-bh198xgl	360	48	,	,	,
cord-259603-bh198xgl	360	49	picornaviruses	picornaviruses	NNP
cord-259603-bh198xgl	360	50	)	)	-RRB-
cord-259603-bh198xgl	360	51	.	.	.
cord-259603-bh198xgl	361	1	The	the	DT
cord-259603-bh198xgl	361	2	presence	presence	NN
cord-259603-bh198xgl	361	3	of	of	IN
cord-259603-bh198xgl	361	4	a	a	DT
cord-259603-bh198xgl	361	5	SF1	SF1	NNP
cord-259603-bh198xgl	361	6	helicase	helicase	NN
cord-259603-bh198xgl	361	7	(	(	-LRB-
cord-259603-bh198xgl	361	8	HEL1	HEL1	NNP
cord-259603-bh198xgl	361	9	)	)	-RRB-
cord-259603-bh198xgl	361	10	domain	domain	NN
cord-259603-bh198xgl	361	11	in	in	IN
cord-259603-bh198xgl	361	12	the	the	DT
cord-259603-bh198xgl	361	13	CoV	CoV	NNP
cord-259603-bh198xgl	361	14	replicase	replicase	NNP
cord-259603-bh198xgl	361	15	polyprotein	polyprotein	NNP
cord-259603-bh198xgl	361	16	was	be	VBD
cord-259603-bh198xgl	361	17	discovered	discover	VBN
cord-259603-bh198xgl	361	18	upon	upon	IN
cord-259603-bh198xgl	361	19	the	the	DT
cord-259603-bh198xgl	361	20	early	early	JJ
cord-259603-bh198xgl	361	21	in	in	IN
cord-259603-bh198xgl	361	22	-	-	HYPH
cord-259603-bh198xgl	361	23	depth	depth	NN
cord-259603-bh198xgl	361	24	analysis	analysis	NN
cord-259603-bh198xgl	361	25	of	of	IN
cord-259603-bh198xgl	361	26	the	the	DT
cord-259603-bh198xgl	361	27	first	first	JJ
cord-259603-bh198xgl	361	28	full	full	JJ
cord-259603-bh198xgl	361	29	-	-	HYPH
cord-259603-bh198xgl	361	30	length	length	NN
cord-259603-bh198xgl	361	31	CoV	cov	NN
cord-259603-bh198xgl	361	32	genome	genome	NN
cord-259603-bh198xgl	361	33	sequence	sequence	NN
cord-259603-bh198xgl	361	34	that	that	WDT
cord-259603-bh198xgl	361	35	became	become	VBD
cord-259603-bh198xgl	361	36	available	available	JJ
cord-259603-bh198xgl	361	37	(	(	-LRB-
cord-259603-bh198xgl	361	38	IBV	IBV	NNP
cord-259603-bh198xgl	361	39	)	)	-RRB-
cord-259603-bh198xgl	362	1	(	(	-LRB-
cord-259603-bh198xgl	362	2	Gorbalenya	Gorbalenya	NNP
cord-259603-bh198xgl	362	3	et	et	NNP
cord-259603-bh198xgl	362	4	al	al	NNP
cord-259603-bh198xgl	362	5	.	.	NNP
cord-259603-bh198xgl	362	6	,	,	,
cord-259603-bh198xgl	362	7	1989	1989	CD
cord-259603-bh198xgl	362	8	)	)	-RRB-
cord-259603-bh198xgl	362	9	.	.	.
cord-259603-bh198xgl	363	1	The	the	DT
cord-259603-bh198xgl	363	2	HEL1	HEL1	NNP
cord-259603-bh198xgl	363	3	domain	domain	NN
cord-259603-bh198xgl	363	4	maps	map	NNS
cord-259603-bh198xgl	363	5	to	to	IN
cord-259603-bh198xgl	363	6	the	the	DT
cord-259603-bh198xgl	363	7	C	C	NNP
cord-259603-bh198xgl	363	8	-	-	HYPH
cord-259603-bh198xgl	363	9	terminal	terminal	NN
cord-259603-bh198xgl	363	10	part	part	NN
cord-259603-bh198xgl	363	11	of	of	IN
cord-259603-bh198xgl	363	12	the	the	DT
cord-259603-bh198xgl	363	13	replicase	replicase	NN
cord-259603-bh198xgl	363	14	cleavage	cleavage	NN
cord-259603-bh198xgl	363	15	product	product	NN
cord-259603-bh198xgl	363	16	that	that	WDT
cord-259603-bh198xgl	363	17	is	be	VBZ
cord-259603-bh198xgl	363	18	now	now	RB
cord-259603-bh198xgl	363	19	known	know	VBN
cord-259603-bh198xgl	363	20	as	as	IN
cord-259603-bh198xgl	363	21	nsp13	nsp13	NNP
cord-259603-bh198xgl	363	22	,	,	,
cord-259603-bh198xgl	363	23	which	which	WDT
cord-259603-bh198xgl	363	24	is	be	VBZ
cord-259603-bh198xgl	363	25	about	about	RB
cord-259603-bh198xgl	363	26	600	600	CD
cord-259603-bh198xgl	363	27	residues	residue	NNS
cord-259603-bh198xgl	363	28	long	long	RB
cord-259603-bh198xgl	363	29	.	.	.
cord-259603-bh198xgl	364	1	The	the	DT
cord-259603-bh198xgl	364	2	CoV	cov	NN
cord-259603-bh198xgl	364	3	HEL1	HEL1	NNP
cord-259603-bh198xgl	364	4	domain	domain	NN
cord-259603-bh198xgl	364	5	contains	contain	VBZ
cord-259603-bh198xgl	364	6	all	all	DT
cord-259603-bh198xgl	364	7	characteristic	characteristic	JJ
cord-259603-bh198xgl	364	8	sequence	sequence	NN
cord-259603-bh198xgl	364	9	motifs	motif	NNS
cord-259603-bh198xgl	364	10	of	of	IN
cord-259603-bh198xgl	364	11	the	the	DT
cord-259603-bh198xgl	364	12	SF1	SF1	NNP
cord-259603-bh198xgl	364	13	superfamily	superfamily	NN
cord-259603-bh198xgl	364	14	.	.	.
cord-259603-bh198xgl	365	1	The	the	DT
cord-259603-bh198xgl	365	2	N	n	CD
cord-259603-bh198xgl	365	3	-	-	HYPH
cord-259603-bh198xgl	365	4	terminal	terminal	JJ
cord-259603-bh198xgl	365	5	part	part	NN
cord-259603-bh198xgl	365	6	of	of	IN
cord-259603-bh198xgl	365	7	nsp13	nsp13	NNP
cord-259603-bh198xgl	365	8	is	be	VBZ
cord-259603-bh198xgl	365	9	formed	form	VBN
cord-259603-bh198xgl	365	10	by	by	IN
cord-259603-bh198xgl	365	11	a	a	DT
cord-259603-bh198xgl	365	12	multinuclear	multinuclear	NN
cord-259603-bh198xgl	365	13	ZBD	ZBD	NNP
cord-259603-bh198xgl	365	14	,	,	,
cord-259603-bh198xgl	365	15	one	one	CD
cord-259603-bh198xgl	365	16	of	of	IN
cord-259603-bh198xgl	365	17	the	the	DT
cord-259603-bh198xgl	365	18	most	most	RBS
cord-259603-bh198xgl	365	19	conserved	conserve	VBN
cord-259603-bh198xgl	365	20	domains	domain	NNS
cord-259603-bh198xgl	365	21	across	across	IN
cord-259603-bh198xgl	365	22	the	the	DT
cord-259603-bh198xgl	365	23	order	order	NN
cord-259603-bh198xgl	365	24	Nidovirales	Nidovirales	NNP
cord-259603-bh198xgl	365	25	(	(	-LRB-
cord-259603-bh198xgl	365	26	Gorbalenya	Gorbalenya	NNP
cord-259603-bh198xgl	365	27	,	,	,
cord-259603-bh198xgl	365	28	2001	2001	CD
cord-259603-bh198xgl	365	29	;	;	:
cord-259603-bh198xgl	365	30	Nga	Nga	NNP
cord-259603-bh198xgl	365	31	et	et	NNP
cord-259603-bh198xgl	365	32	al	al	NNP
cord-259603-bh198xgl	365	33	.	.	NNP
cord-259603-bh198xgl	365	34	,	,	,
cord-259603-bh198xgl	365	35	2011	2011	CD
cord-259603-bh198xgl	365	36	)	)	-RRB-
cord-259603-bh198xgl	365	37	.	.	.
cord-259603-bh198xgl	366	1	This	this	DT
cord-259603-bh198xgl	366	2	qualification	qualification	NN
cord-259603-bh198xgl	366	3	also	also	RB
cord-259603-bh198xgl	366	4	applies	apply	VBZ
cord-259603-bh198xgl	366	5	to	to	IN
cord-259603-bh198xgl	366	6	the	the	DT
cord-259603-bh198xgl	366	7	helicase	helicase	NN
cord-259603-bh198xgl	366	8	-	-	HYPH
cord-259603-bh198xgl	366	9	containing	contain	VBG
cord-259603-bh198xgl	366	10	subunit	subunit	NN
cord-259603-bh198xgl	366	11	as	as	IN
cord-259603-bh198xgl	366	12	a	a	DT
cord-259603-bh198xgl	366	13	whole	whole	NN
cord-259603-bh198xgl	366	14	,	,	,
cord-259603-bh198xgl	366	15	despite	despite	IN
cord-259603-bh198xgl	366	16	considerable	considerable	JJ
cord-259603-bh198xgl	366	17	size	size	NN
cord-259603-bh198xgl	366	18	differences	difference	NNS
cord-259603-bh198xgl	366	19	between	between	IN
cord-259603-bh198xgl	366	20	,	,	,
cord-259603-bh198xgl	366	21	e.g.	e.g.	RB
cord-259603-bh198xgl	366	22	,	,	,
cord-259603-bh198xgl	366	23	CoV	CoV	NNP
cord-259603-bh198xgl	366	24	nsp13	nsp13	NNP
cord-259603-bh198xgl	366	25	and	and	CC
cord-259603-bh198xgl	366	26	its	-PRON-	PRP$
cord-259603-bh198xgl	366	27	arterivirus	arterivirus	NN
cord-259603-bh198xgl	366	28	homolog	homolog	NN
cord-259603-bh198xgl	366	29	(	(	-LRB-
cord-259603-bh198xgl	366	30	designated	designate	VBN
cord-259603-bh198xgl	366	31	nsp10	nsp10	CD
cord-259603-bh198xgl	366	32	)	)	-RRB-
cord-259603-bh198xgl	367	1	(	(	-LRB-
cord-259603-bh198xgl	367	2	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	367	3	et	et	NNP
cord-259603-bh198xgl	367	4	al	al	NNP
cord-259603-bh198xgl	367	5	.	.	NNP
cord-259603-bh198xgl	367	6	,	,	,
cord-259603-bh198xgl	367	7	2015c	2015c	CD
cord-259603-bh198xgl	367	8	)	)	-RRB-
cord-259603-bh198xgl	367	9	.	.	.
cord-259603-bh198xgl	368	1	The	the	DT
cord-259603-bh198xgl	368	2	ZBD	ZBD	NNP
cord-259603-bh198xgl	368	3	and	and	CC
cord-259603-bh198xgl	368	4	HEL1	HEL1	NNP
cord-259603-bh198xgl	368	5	domains	domain	NNS
cord-259603-bh198xgl	368	6	occupy	occupy	VBP
cord-259603-bh198xgl	368	7	a	a	DT
cord-259603-bh198xgl	368	8	conserved	conserve	VBN
cord-259603-bh198xgl	368	9	position	position	NN
cord-259603-bh198xgl	368	10	downstream	downstream	RB
cord-259603-bh198xgl	368	11	of	of	IN
cord-259603-bh198xgl	368	12	the	the	DT
cord-259603-bh198xgl	368	13	RdRp	RdRp	NNP
cord-259603-bh198xgl	368	14	domain	domain	NN
cord-259603-bh198xgl	368	15	in	in	IN
cord-259603-bh198xgl	368	16	all	all	DT
cord-259603-bh198xgl	368	17	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	368	18	replicase	replicase	NNP
cord-259603-bh198xgl	368	19	polyproteins	polyproteins	NNP
cord-259603-bh198xgl	368	20	studied	study	VBD
cord-259603-bh198xgl	368	21	so	so	RB
cord-259603-bh198xgl	368	22	far	far	RB
cord-259603-bh198xgl	368	23	.	.	.
cord-259603-bh198xgl	369	1	SF1	SF1	NNP
cord-259603-bh198xgl	369	2	helicases	helicase	NNS
cord-259603-bh198xgl	369	3	contain	contain	VBP
cord-259603-bh198xgl	369	4	at	at	IN
cord-259603-bh198xgl	369	5	least	least	JJS
cord-259603-bh198xgl	369	6	a	a	DT
cord-259603-bh198xgl	369	7	dozen	dozen	NN
cord-259603-bh198xgl	369	8	conserved	conserve	VBN
cord-259603-bh198xgl	369	9	motifs	motif	NNS
cord-259603-bh198xgl	369	10	that	that	WDT
cord-259603-bh198xgl	369	11	direct	direct	VBP
cord-259603-bh198xgl	369	12	the	the	DT
cord-259603-bh198xgl	369	13	binding	binding	NN
cord-259603-bh198xgl	369	14	of	of	IN
cord-259603-bh198xgl	369	15	NTPs	ntp	NNS
cord-259603-bh198xgl	369	16	and	and	CC
cord-259603-bh198xgl	369	17	nucleic	nucleic	JJ
cord-259603-bh198xgl	369	18	acids	acid	NNS
cord-259603-bh198xgl	369	19	.	.	.
cord-259603-bh198xgl	370	1	Of	of	IN
cord-259603-bh198xgl	370	2	these	these	DT
cord-259603-bh198xgl	370	3	,	,	,
cord-259603-bh198xgl	370	4	motifs	motifs	VBP
cord-259603-bh198xgl	370	5	I	-PRON-	PRP
cord-259603-bh198xgl	370	6	and	and	CC
cord-259603-bh198xgl	370	7	II	II	NNP
cord-259603-bh198xgl	370	8	(	(	-LRB-
cord-259603-bh198xgl	370	9	also	also	RB
cord-259603-bh198xgl	370	10	known	know	VBN
cord-259603-bh198xgl	370	11	as	as	IN
cord-259603-bh198xgl	370	12	the	the	DT
cord-259603-bh198xgl	370	13	Walker	Walker	NNP
cord-259603-bh198xgl	370	14	A	A	NNP
cord-259603-bh198xgl	370	15	and	and	CC
cord-259603-bh198xgl	370	16	B	b	NN
cord-259603-bh198xgl	370	17	boxes	box	NNS
cord-259603-bh198xgl	370	18	)	)	-RRB-
cord-259603-bh198xgl	370	19	are	be	VBP
cord-259603-bh198xgl	370	20	common	common	JJ
cord-259603-bh198xgl	370	21	to	to	IN
cord-259603-bh198xgl	370	22	helicases	helicase	NNS
cord-259603-bh198xgl	370	23	of	of	IN
cord-259603-bh198xgl	370	24	all	all	DT
cord-259603-bh198xgl	370	25	SFs	sf	NNS
cord-259603-bh198xgl	370	26	as	as	RB
cord-259603-bh198xgl	370	27	well	well	RB
cord-259603-bh198xgl	370	28	as	as	IN
cord-259603-bh198xgl	370	29	NTPases	ntpase	NNS
cord-259603-bh198xgl	370	30	.	.	.
cord-259603-bh198xgl	371	1	Structurally	structurally	RB
cord-259603-bh198xgl	371	2	,	,	,
cord-259603-bh198xgl	371	3	the	the	DT
cord-259603-bh198xgl	371	4	catalytic	catalytic	JJ
cord-259603-bh198xgl	371	5	core	core	NN
cord-259603-bh198xgl	371	6	of	of	IN
cord-259603-bh198xgl	371	7	SF1	SF1	NNP
cord-259603-bh198xgl	371	8	helicases	helicase	NNS
cord-259603-bh198xgl	371	9	like	like	IN
cord-259603-bh198xgl	371	10	the	the	DT
cord-259603-bh198xgl	371	11	CoV	cov	NN
cord-259603-bh198xgl	371	12	HEL1	HEL1	NNP
cord-259603-bh198xgl	371	13	domain	domain	NN
cord-259603-bh198xgl	371	14	is	be	VBZ
cord-259603-bh198xgl	371	15	formed	form	VBN
cord-259603-bh198xgl	371	16	by	by	IN
cord-259603-bh198xgl	371	17	two	two	CD
cord-259603-bh198xgl	371	18	RecA	RecA	NNP
cord-259603-bh198xgl	371	19	-	-	HYPH
cord-259603-bh198xgl	371	20	like	like	JJ
cord-259603-bh198xgl	371	21	domains	domain	NNS
cord-259603-bh198xgl	371	22	,	,	,
cord-259603-bh198xgl	371	23	designated	designate	VBN
cord-259603-bh198xgl	371	24	1A	1a	NN
cord-259603-bh198xgl	371	25	and	and	CC
cord-259603-bh198xgl	371	26	2A	2a	CD
cord-259603-bh198xgl	372	1	(	(	-LRB-
cord-259603-bh198xgl	372	2	Fig	Fig	NNP
cord-259603-bh198xgl	372	3	.	.	NNP
cord-259603-bh198xgl	372	4	4	4	CD
cord-259603-bh198xgl	372	5	)	)	-RRB-
cord-259603-bh198xgl	372	6	,	,	,
cord-259603-bh198xgl	372	7	that	that	WDT
cord-259603-bh198xgl	372	8	bind	bind	VBP
cord-259603-bh198xgl	372	9	to	to	IN
cord-259603-bh198xgl	372	10	nucleic	nucleic	JJ
cord-259603-bh198xgl	372	11	acids	acid	NNS
cord-259603-bh198xgl	372	12	through	through	IN
cord-259603-bh198xgl	372	13	stacking	stack	VBG
cord-259603-bh198xgl	372	14	interactions	interaction	NNS
cord-259603-bh198xgl	372	15	of	of	IN
cord-259603-bh198xgl	372	16	aromatic	aromatic	JJ
cord-259603-bh198xgl	372	17	residues	residue	NNS
cord-259603-bh198xgl	372	18	with	with	IN
cord-259603-bh198xgl	372	19	the	the	DT
cord-259603-bh198xgl	372	20	bases	basis	NNS
cord-259603-bh198xgl	372	21	of	of	IN
cord-259603-bh198xgl	372	22	their	-PRON-	PRP$
cord-259603-bh198xgl	372	23	nucleic	nucleic	JJ
cord-259603-bh198xgl	372	24	acid	acid	NN
cord-259603-bh198xgl	372	25	substrates	substrate	NNS
cord-259603-bh198xgl	372	26	(	(	-LRB-
cord-259603-bh198xgl	372	27	Velankar	Velankar	NNP
cord-259603-bh198xgl	372	28	et	et	FW
cord-259603-bh198xgl	372	29	al	al	NNP
cord-259603-bh198xgl	372	30	.	.	NNP
cord-259603-bh198xgl	372	31	,	,	,
cord-259603-bh198xgl	372	32	1999	1999	CD
cord-259603-bh198xgl	372	33	)	)	-RRB-
cord-259603-bh198xgl	372	34	.	.	.
cord-259603-bh198xgl	373	1	Cyclic	cyclic	JJ
cord-259603-bh198xgl	373	2	conformational	conformational	JJ
cord-259603-bh198xgl	373	3	changes	change	NNS
cord-259603-bh198xgl	373	4	of	of	IN
cord-259603-bh198xgl	373	5	the	the	DT
cord-259603-bh198xgl	373	6	RecA	RecA	NNP
cord-259603-bh198xgl	373	7	-	-	HYPH
cord-259603-bh198xgl	373	8	like	like	JJ
cord-259603-bh198xgl	373	9	domains	domain	NNS
cord-259603-bh198xgl	373	10	mediate	mediate	VBP
cord-259603-bh198xgl	373	11	the	the	DT
cord-259603-bh198xgl	373	12	conversion	conversion	NN
cord-259603-bh198xgl	373	13	of	of	IN
cord-259603-bh198xgl	373	14	the	the	DT
cord-259603-bh198xgl	373	15	energy	energy	NN
cord-259603-bh198xgl	373	16	from	from	IN
cord-259603-bh198xgl	373	17	hydrolysis	hydrolysis	NN
cord-259603-bh198xgl	373	18	of	of	IN
cord-259603-bh198xgl	373	19	the	the	DT
cord-259603-bh198xgl	373	20	phosphodiester	phosphodiester	NN
cord-259603-bh198xgl	373	21	bonds	bond	NNS
cord-259603-bh198xgl	373	22	of	of	IN
cord-259603-bh198xgl	373	23	NTPs	ntp	NNS
cord-259603-bh198xgl	373	24	into	into	IN
cord-259603-bh198xgl	373	25	directional	directional	JJ
cord-259603-bh198xgl	373	26	movement	movement	NN
cord-259603-bh198xgl	373	27	along	along	IN
cord-259603-bh198xgl	373	28	the	the	DT
cord-259603-bh198xgl	373	29	nucleic	nucleic	JJ
cord-259603-bh198xgl	373	30	acid	acid	NN
cord-259603-bh198xgl	373	31	substrate	substrate	NN
cord-259603-bh198xgl	373	32	,	,	,
cord-259603-bh198xgl	373	33	with	with	IN
cord-259603-bh198xgl	373	34	the	the	DT
cord-259603-bh198xgl	373	35	so	so	RB
cord-259603-bh198xgl	373	36	-	-	HYPH
cord-259603-bh198xgl	373	37	called	call	VBN
cord-259603-bh198xgl	373	38	"	"	``
cord-259603-bh198xgl	373	39	inchworm	inchworm	NN
cord-259603-bh198xgl	373	40	"	"	''
cord-259603-bh198xgl	373	41	model	model	NN
cord-259603-bh198xgl	373	42	now	now	RB
cord-259603-bh198xgl	373	43	widely	widely	RB
cord-259603-bh198xgl	373	44	being	be	VBG
cord-259603-bh198xgl	373	45	considered	consider	VBN
cord-259603-bh198xgl	373	46	as	as	RB
cord-259603-bh198xgl	373	47	best	good	JJS
cord-259603-bh198xgl	373	48	supported	support	VBN
cord-259603-bh198xgl	373	49	by	by	IN
cord-259603-bh198xgl	373	50	the	the	DT
cord-259603-bh198xgl	373	51	available	available	JJ
cord-259603-bh198xgl	373	52	experimental	experimental	JJ
cord-259603-bh198xgl	373	53	data	datum	NNS
cord-259603-bh198xgl	374	1	(	(	-LRB-
cord-259603-bh198xgl	374	2	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	374	3	et	et	NNP
cord-259603-bh198xgl	374	4	al	al	NNP
cord-259603-bh198xgl	374	5	.	.	NNP
cord-259603-bh198xgl	374	6	,	,	,
cord-259603-bh198xgl	374	7	2015c	2015c	CD
cord-259603-bh198xgl	374	8	;	;	:
cord-259603-bh198xgl	375	1	Velankar	Velankar	NNP
cord-259603-bh198xgl	375	2	et	et	FW
cord-259603-bh198xgl	375	3	al	al	NNP
cord-259603-bh198xgl	375	4	.	.	.
cord-259603-bh198xgl	376	1	,	,	,
cord-259603-bh198xgl	376	2	1999	1999	CD
cord-259603-bh198xgl	376	3	;	;	:
cord-259603-bh198xgl	376	4	Yarranton	Yarranton	NNP
cord-259603-bh198xgl	376	5	and	and	CC
cord-259603-bh198xgl	376	6	Gefter	Gefter	NNP
cord-259603-bh198xgl	376	7	,	,	,
cord-259603-bh198xgl	376	8	1979	1979	CD
cord-259603-bh198xgl	376	9	)	)	-RRB-
cord-259603-bh198xgl	376	10	.	.	.
cord-259603-bh198xgl	377	1	Additional	additional	JJ
cord-259603-bh198xgl	377	2	domains	domain	NNS
cord-259603-bh198xgl	377	3	,	,	,
cord-259603-bh198xgl	377	4	located	locate	VBN
cord-259603-bh198xgl	377	5	upor	upor	JJ
cord-259603-bh198xgl	377	6	downstream	downstream	RB
cord-259603-bh198xgl	377	7	of	of	IN
cord-259603-bh198xgl	377	8	1A	1a	CD
cord-259603-bh198xgl	377	9	and	and	CC
cord-259603-bh198xgl	377	10	2A	2a	CD
cord-259603-bh198xgl	377	11	,	,	,
cord-259603-bh198xgl	377	12	or	or	CC
cord-259603-bh198xgl	377	13	inserted	insert	VBN
cord-259603-bh198xgl	377	14	internally	internally	RB
cord-259603-bh198xgl	377	15	,	,	,
cord-259603-bh198xgl	377	16	can	can	MD
cord-259603-bh198xgl	377	17	mediate	mediate	VB
cord-259603-bh198xgl	377	18	supplemental	supplemental	JJ
cord-259603-bh198xgl	377	19	protein	protein	NN
cord-259603-bh198xgl	377	20	-	-	HYPH
cord-259603-bh198xgl	377	21	protein	protein	NN
cord-259603-bh198xgl	377	22	and	and	CC
cord-259603-bh198xgl	377	23	protein	protein	NN
cord-259603-bh198xgl	377	24	-	-	HYPH
cord-259603-bh198xgl	377	25	nucleic	nucleic	JJ
cord-259603-bh198xgl	377	26	acid	acid	NN
cord-259603-bh198xgl	377	27	interactions	interaction	NNS
cord-259603-bh198xgl	377	28	or	or	CC
cord-259603-bh198xgl	377	29	enzymatic	enzymatic	JJ
cord-259603-bh198xgl	377	30	activities	activity	NNS
cord-259603-bh198xgl	377	31	,	,	,
cord-259603-bh198xgl	377	32	thus	thus	RB
cord-259603-bh198xgl	377	33	contributing	contribute	VBG
cord-259603-bh198xgl	377	34	to	to	IN
cord-259603-bh198xgl	377	35	the	the	DT
cord-259603-bh198xgl	377	36	functional	functional	JJ
cord-259603-bh198xgl	377	37	versatility	versatility	NN
cord-259603-bh198xgl	377	38	and	and	CC
cord-259603-bh198xgl	377	39	specificity	specificity	NN
cord-259603-bh198xgl	377	40	of	of	IN
cord-259603-bh198xgl	377	41	the	the	DT
cord-259603-bh198xgl	377	42	enzyme	enzyme	NN
cord-259603-bh198xgl	377	43	(	(	-LRB-
cord-259603-bh198xgl	377	44	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	377	45	et	et	NNP
cord-259603-bh198xgl	377	46	al	al	NNP
cord-259603-bh198xgl	377	47	.	.	NNP
cord-259603-bh198xgl	377	48	,	,	,
cord-259603-bh198xgl	377	49	2015c	2015c	CD
cord-259603-bh198xgl	377	50	;	;	:
cord-259603-bh198xgl	377	51	Singleton	Singleton	NNP
cord-259603-bh198xgl	377	52	et	et	NNP
cord-259603-bh198xgl	377	53	al	al	NNP
cord-259603-bh198xgl	377	54	.	.	NNP
cord-259603-bh198xgl	377	55	,	,	,
cord-259603-bh198xgl	377	56	2007	2007	CD
cord-259603-bh198xgl	377	57	)	)	-RRB-
cord-259603-bh198xgl	377	58	.	.	.
cord-259603-bh198xgl	378	1	Within	within	IN
cord-259603-bh198xgl	378	2	helicase	helicase	NNP
cord-259603-bh198xgl	378	3	SF1	SF1	NNP
cord-259603-bh198xgl	378	4	,	,	,
cord-259603-bh198xgl	378	5	the	the	DT
cord-259603-bh198xgl	378	6	CoV	cov	NN
cord-259603-bh198xgl	378	7	HEL1	HEL1	NNP
cord-259603-bh198xgl	378	8	domain	domain	NN
cord-259603-bh198xgl	378	9	belongs	belong	VBZ
cord-259603-bh198xgl	378	10	to	to	IN
cord-259603-bh198xgl	378	11	the	the	DT
cord-259603-bh198xgl	378	12	Upf1-like	Upf1-like	NNP
cord-259603-bh198xgl	378	13	family	family	NN
cord-259603-bh198xgl	378	14	(	(	-LRB-
cord-259603-bh198xgl	378	15	SF1B	sf1b	NN
cord-259603-bh198xgl	378	16	)	)	-RRB-
cord-259603-bh198xgl	378	17	which	which	WDT
cord-259603-bh198xgl	378	18	is	be	VBZ
cord-259603-bh198xgl	378	19	characterized	characterize	VBN
cord-259603-bh198xgl	378	20	by	by	IN
cord-259603-bh198xgl	378	21	moving	move	VBG
cord-259603-bh198xgl	378	22	in	in	IN
cord-259603-bh198xgl	378	23	the	the	DT
cord-259603-bh198xgl	378	24	5	5	CD
cord-259603-bh198xgl	378	25	0	0	CD
cord-259603-bh198xgl	378	26	-to-3	-to-3	CD
cord-259603-bh198xgl	378	27	0	0	CD
cord-259603-bh198xgl	378	28	direction	direction	NN
cord-259603-bh198xgl	378	29	along	along	IN
cord-259603-bh198xgl	378	30	the	the	DT
cord-259603-bh198xgl	378	31	nucleic	nucleic	JJ
cord-259603-bh198xgl	378	32	acid	acid	NN
cord-259603-bh198xgl	378	33	strand	strand	NN
cord-259603-bh198xgl	378	34	to	to	TO
cord-259603-bh198xgl	378	35	which	which	WDT
cord-259603-bh198xgl	378	36	they	-PRON-	PRP
cord-259603-bh198xgl	378	37	bind	bind	VBP
cord-259603-bh198xgl	378	38	.	.	.
cord-259603-bh198xgl	379	1	Upf1-like	upf1-like	IN
cord-259603-bh198xgl	379	2	helicases	helicase	NNS
cord-259603-bh198xgl	379	3	may	may	MD
cord-259603-bh198xgl	379	4	unwind	unwind	VB
cord-259603-bh198xgl	379	5	either	either	CC
cord-259603-bh198xgl	379	6	DNA	DNA	NNP
cord-259603-bh198xgl	379	7	or	or	CC
cord-259603-bh198xgl	379	8	RNA	RNA	NNP
cord-259603-bh198xgl	379	9	and	and	CC
cord-259603-bh198xgl	379	10	,	,	,
cord-259603-bh198xgl	379	11	in	in	IN
cord-259603-bh198xgl	379	12	some	some	DT
cord-259603-bh198xgl	379	13	cases	case	NNS
cord-259603-bh198xgl	379	14	,	,	,
cord-259603-bh198xgl	379	15	also	also	RB
cord-259603-bh198xgl	379	16	both	both	DT
cord-259603-bh198xgl	379	17	substrates	substrate	NNS
cord-259603-bh198xgl	379	18	without	without	IN
cord-259603-bh198xgl	379	19	a	a	DT
cord-259603-bh198xgl	379	20	clear	clear	JJ
cord-259603-bh198xgl	379	21	preference	preference	NN
cord-259603-bh198xgl	379	22	,	,	,
cord-259603-bh198xgl	379	23	as	as	IN
cord-259603-bh198xgl	379	24	was	be	VBD
cord-259603-bh198xgl	379	25	readily	readily	RB
cord-259603-bh198xgl	379	26	observed	observe	VBN
cord-259603-bh198xgl	379	27	during	during	IN
cord-259603-bh198xgl	379	28	the	the	DT
cord-259603-bh198xgl	379	29	in	in	FW
cord-259603-bh198xgl	379	30	vitro	vitro	FW
cord-259603-bh198xgl	379	31	characterization	characterization	NN
cord-259603-bh198xgl	379	32	of	of	IN
cord-259603-bh198xgl	379	33	different	different	JJ
cord-259603-bh198xgl	379	34	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	379	35	helicases	helicase	NNS
cord-259603-bh198xgl	379	36	.	.	.
cord-259603-bh198xgl	380	1	The	the	DT
cord-259603-bh198xgl	380	2	CoV	cov	NN
cord-259603-bh198xgl	380	3	HEL1	HEL1	NNP
cord-259603-bh198xgl	380	4	activity	activity	NN
cord-259603-bh198xgl	380	5	was	be	VBD
cord-259603-bh198xgl	380	6	first	first	RB
cord-259603-bh198xgl	380	7	demonstrated	demonstrate	VBN
cord-259603-bh198xgl	380	8	in	in	IN
cord-259603-bh198xgl	380	9	vitro	vitro	FW
cord-259603-bh198xgl	380	10	using	use	VBG
cord-259603-bh198xgl	380	11	recombinant	recombinant	JJ
cord-259603-bh198xgl	380	12	HCoV-229E	HCoV-229E	NNP
cord-259603-bh198xgl	380	13	nsp13	nsp13	ADD
cord-259603-bh198xgl	381	1	(	(	-LRB-
cord-259603-bh198xgl	381	2	Seybert	Seybert	NNP
cord-259603-bh198xgl	381	3	et	et	NNP
cord-259603-bh198xgl	381	4	al	al	NNP
cord-259603-bh198xgl	381	5	.	.	NNP
cord-259603-bh198xgl	381	6	,	,	,
cord-259603-bh198xgl	381	7	2000a	2000a	CD
cord-259603-bh198xgl	381	8	)	)	-RRB-
cord-259603-bh198xgl	381	9	.	.	.
cord-259603-bh198xgl	382	1	Bacterially	Bacterially	NNP
cord-259603-bh198xgl	382	2	expressed	express	VBD
cord-259603-bh198xgl	382	3	nsp13	nsp13	NNP
cord-259603-bh198xgl	382	4	from	from	IN
cord-259603-bh198xgl	382	5	HCoV-229E	HCoV-229E	NNP
cord-259603-bh198xgl	382	6	and	and	CC
cord-259603-bh198xgl	382	7	SARS	SARS	NNP
cord-259603-bh198xgl	382	8	-	-	HYPH
cord-259603-bh198xgl	382	9	CoV	CoV	NNP
cord-259603-bh198xgl	382	10	,	,	,
cord-259603-bh198xgl	382	11	and	and	CC
cord-259603-bh198xgl	382	12	also	also	RB
cord-259603-bh198xgl	382	13	the	the	DT
cord-259603-bh198xgl	382	14	homologous	homologous	JJ
cord-259603-bh198xgl	382	15	helicase	helicase	NN
cord-259603-bh198xgl	382	16	(	(	-LRB-
cord-259603-bh198xgl	382	17	nsp10	nsp10	NNP
cord-259603-bh198xgl	382	18	)	)	-RRB-
cord-259603-bh198xgl	382	19	of	of	IN
cord-259603-bh198xgl	382	20	the	the	DT
cord-259603-bh198xgl	382	21	arterivirus	arterivirus	NNP
cord-259603-bh198xgl	382	22	EAV	EAV	NNP
cord-259603-bh198xgl	382	23	,	,	,
cord-259603-bh198xgl	382	24	displayed	display	VBD
cord-259603-bh198xgl	382	25	5	5	CD
cord-259603-bh198xgl	382	26	0	0	CD
cord-259603-bh198xgl	382	27	-to-3	-to-3	CD
cord-259603-bh198xgl	382	28	0	0	CD
cord-259603-bh198xgl	382	29	unwinding	unwind	VBG
cord-259603-bh198xgl	382	30	activity	activity	NN
cord-259603-bh198xgl	382	31	on	on	IN
cord-259603-bh198xgl	382	32	double	double	RB
cord-259603-bh198xgl	382	33	-	-	HYPH
cord-259603-bh198xgl	382	34	stranded	strand	VBN
cord-259603-bh198xgl	382	35	RNA	RNA	NNP
cord-259603-bh198xgl	382	36	or	or	CC
cord-259603-bh198xgl	382	37	DNA	dna	NN
cord-259603-bh198xgl	382	38	substrates	substrate	NNS
cord-259603-bh198xgl	382	39	containing	contain	VBG
cord-259603-bh198xgl	382	40	single	single	RB
cord-259603-bh198xgl	382	41	-	-	HYPH
cord-259603-bh198xgl	382	42	stranded	strand	VBN
cord-259603-bh198xgl	382	43	5	5	CD
cord-259603-bh198xgl	382	44	0	0	CD
cord-259603-bh198xgl	382	45	overhangs	overhang	NNS
cord-259603-bh198xgl	382	46	(	(	-LRB-
cord-259603-bh198xgl	382	47	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	382	48	and	and	CC
cord-259603-bh198xgl	382	49	Ziebuhr	Ziebuhr	NNP
cord-259603-bh198xgl	382	50	,	,	,
cord-259603-bh198xgl	382	51	2004	2004	CD
cord-259603-bh198xgl	382	52	;	;	:
cord-259603-bh198xgl	382	53	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	382	54	et	et	NNP
cord-259603-bh198xgl	382	55	al	al	NNP
cord-259603-bh198xgl	382	56	.	.	NNP
cord-259603-bh198xgl	382	57	,	,	,
cord-259603-bh198xgl	382	58	2004b	2004b	CD
cord-259603-bh198xgl	382	59	;	;	:
cord-259603-bh198xgl	383	1	Seybert	Seybert	NNP
cord-259603-bh198xgl	383	2	et	et	NNP
cord-259603-bh198xgl	383	3	al	al	NNP
cord-259603-bh198xgl	383	4	.	.	NNP
cord-259603-bh198xgl	383	5	,	,	,
cord-259603-bh198xgl	383	6	2000a	2000a	CD
cord-259603-bh198xgl	383	7	,	,	,
cord-259603-bh198xgl	383	8	b	b	LS
cord-259603-bh198xgl	384	1	;	;	:
cord-259603-bh198xgl	384	2	Tanner	Tanner	NNP
cord-259603-bh198xgl	384	3	et	et	NNP
cord-259603-bh198xgl	384	4	al	al	NNP
cord-259603-bh198xgl	384	5	.	.	NNP
cord-259603-bh198xgl	384	6	,	,	,
cord-259603-bh198xgl	384	7	2003	2003	CD
cord-259603-bh198xgl	384	8	)	)	-RRB-
cord-259603-bh198xgl	384	9	.	.	.
cord-259603-bh198xgl	385	1	Following	follow	VBG
cord-259603-bh198xgl	385	2	the	the	DT
cord-259603-bh198xgl	385	3	biochemical	biochemical	JJ
cord-259603-bh198xgl	385	4	characterization	characterization	NN
cord-259603-bh198xgl	385	5	of	of	IN
cord-259603-bh198xgl	385	6	SARS	SARS	NNP
cord-259603-bh198xgl	385	7	-	-	HYPH
cord-259603-bh198xgl	385	8	CoV	CoV	NNP
cord-259603-bh198xgl	385	9	nsp13	nsp13	NNP
cord-259603-bh198xgl	385	10	,	,	,
cord-259603-bh198xgl	385	11	it	-PRON-	PRP
cord-259603-bh198xgl	385	12	was	be	VBD
cord-259603-bh198xgl	385	13	calculated	calculate	VBN
cord-259603-bh198xgl	385	14	that	that	IN
cord-259603-bh198xgl	385	15	unwinding	unwinding	NN
cord-259603-bh198xgl	385	16	occurs	occur	VBZ
cord-259603-bh198xgl	385	17	in	in	IN
cord-259603-bh198xgl	385	18	discrete	discrete	JJ
cord-259603-bh198xgl	385	19	steps	step	NNS
cord-259603-bh198xgl	385	20	of	of	IN
cord-259603-bh198xgl	385	21	9.3	9.3	CD
cord-259603-bh198xgl	385	22	base	base	NN
cord-259603-bh198xgl	385	23	pairs	pair	NNS
cord-259603-bh198xgl	385	24	each	each	DT
cord-259603-bh198xgl	385	25	,	,	,
cord-259603-bh198xgl	385	26	with	with	IN
cord-259603-bh198xgl	385	27	a	a	DT
cord-259603-bh198xgl	385	28	catalytic	catalytic	JJ
cord-259603-bh198xgl	385	29	rate	rate	NN
cord-259603-bh198xgl	385	30	of	of	IN
cord-259603-bh198xgl	385	31	30	30	CD
cord-259603-bh198xgl	385	32	steps	step	NNS
cord-259603-bh198xgl	385	33	per	per	IN
cord-259603-bh198xgl	385	34	second	second	NN
cord-259603-bh198xgl	385	35	(	(	-LRB-
cord-259603-bh198xgl	385	36	Adedeji	Adedeji	NNP
cord-259603-bh198xgl	385	37	et	et	NNP
cord-259603-bh198xgl	385	38	al	al	NNP
cord-259603-bh198xgl	385	39	.	.	NNP
cord-259603-bh198xgl	385	40	,	,	,
cord-259603-bh198xgl	385	41	2012a	2012a	CD
cord-259603-bh198xgl	385	42	)	)	-RRB-
cord-259603-bh198xgl	385	43	.	.	.
cord-259603-bh198xgl	386	1	The	the	DT
cord-259603-bh198xgl	386	2	nsp13	nsp13	CD
cord-259603-bh198xgl	386	3	NTPase	NTPase	NNP
cord-259603-bh198xgl	386	4	activity	activity	NN
cord-259603-bh198xgl	386	5	can	can	MD
cord-259603-bh198xgl	386	6	use	use	VB
cord-259603-bh198xgl	386	7	all	all	DT
cord-259603-bh198xgl	386	8	four	four	CD
cord-259603-bh198xgl	386	9	natural	natural	JJ
cord-259603-bh198xgl	386	10	ribonucleotides	ribonucleotide	NNS
cord-259603-bh198xgl	386	11	and	and	CC
cord-259603-bh198xgl	386	12	nucleotides	nucleotide	NNS
cord-259603-bh198xgl	386	13	as	as	IN
cord-259603-bh198xgl	386	14	substrate	substrate	NN
cord-259603-bh198xgl	386	15	,	,	,
cord-259603-bh198xgl	386	16	with	with	IN
cord-259603-bh198xgl	386	17	ATP	ATP	NNP
cord-259603-bh198xgl	386	18	,	,	,
cord-259603-bh198xgl	386	19	dATP	datp	NN
cord-259603-bh198xgl	386	20	,	,	,
cord-259603-bh198xgl	386	21	and	and	CC
cord-259603-bh198xgl	386	22	GTP	GTP	NNP
cord-259603-bh198xgl	386	23	being	be	VBG
cord-259603-bh198xgl	386	24	hydrolyzed	hydrolyze	VBN
cord-259603-bh198xgl	386	25	most	most	RBS
cord-259603-bh198xgl	386	26	efficiently	efficiently	RB
cord-259603-bh198xgl	386	27	,	,	,
cord-259603-bh198xgl	386	28	and	and	CC
cord-259603-bh198xgl	386	29	UTP	UTP	NNP
cord-259603-bh198xgl	386	30	being	be	VBG
cord-259603-bh198xgl	386	31	the	the	DT
cord-259603-bh198xgl	386	32	least	least	RBS
cord-259603-bh198xgl	386	33	preferred	preferred	JJ
cord-259603-bh198xgl	386	34	substrate	substrate	NN
cord-259603-bh198xgl	386	35	(	(	-LRB-
cord-259603-bh198xgl	386	36	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	386	37	and	and	CC
cord-259603-bh198xgl	386	38	Ziebuhr	Ziebuhr	NNP
cord-259603-bh198xgl	386	39	,	,	,
cord-259603-bh198xgl	386	40	2004	2004	CD
cord-259603-bh198xgl	386	41	;	;	:
cord-259603-bh198xgl	386	42	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	386	43	et	et	NNP
cord-259603-bh198xgl	386	44	al	al	NNP
cord-259603-bh198xgl	386	45	.	.	NNP
cord-259603-bh198xgl	386	46	,	,	,
cord-259603-bh198xgl	386	47	2004b	2004b	CD
cord-259603-bh198xgl	386	48	;	;	:
cord-259603-bh198xgl	387	1	Tanner	Tanner	NNP
cord-259603-bh198xgl	387	2	et	et	NNP
cord-259603-bh198xgl	387	3	al	al	NNP
cord-259603-bh198xgl	387	4	.	.	NNP
cord-259603-bh198xgl	387	5	,	,	,
cord-259603-bh198xgl	387	6	2003	2003	CD
cord-259603-bh198xgl	387	7	)	)	-RRB-
cord-259603-bh198xgl	387	8	.	.	.
cord-259603-bh198xgl	388	1	Replacement	replacement	NN
cord-259603-bh198xgl	388	2	of	of	IN
cord-259603-bh198xgl	388	3	a	a	DT
cord-259603-bh198xgl	388	4	conserved	conserve	VBN
cord-259603-bh198xgl	388	5	Lys	Lys	NNP
cord-259603-bh198xgl	388	6	in	in	IN
cord-259603-bh198xgl	388	7	motif	motif	NN
cord-259603-bh198xgl	388	8	I	-PRON-	PRP
cord-259603-bh198xgl	388	9	,	,	,
cord-259603-bh198xgl	388	10	the	the	DT
cord-259603-bh198xgl	388	11	Walker	Walker	NNP
cord-259603-bh198xgl	388	12	A	A	NNP
cord-259603-bh198xgl	388	13	box	box	NN
cord-259603-bh198xgl	388	14	(	(	-LRB-
cord-259603-bh198xgl	388	15	Walker	Walker	NNP
cord-259603-bh198xgl	388	16	et	et	NNP
cord-259603-bh198xgl	388	17	al	al	NNP
cord-259603-bh198xgl	388	18	.	.	NNP
cord-259603-bh198xgl	388	19	,	,	,
cord-259603-bh198xgl	388	20	1982	1982	CD
cord-259603-bh198xgl	388	21	)	)	-RRB-
cord-259603-bh198xgl	388	22	,	,	,
cord-259603-bh198xgl	388	23	kills	kill	VBZ
cord-259603-bh198xgl	388	24	the	the	DT
cord-259603-bh198xgl	388	25	in	in	FW
cord-259603-bh198xgl	388	26	vitro	vitro	FW
cord-259603-bh198xgl	388	27	NTPase	NTPase	NNP
cord-259603-bh198xgl	388	28	activity	activity	NN
cord-259603-bh198xgl	388	29	of	of	IN
cord-259603-bh198xgl	388	30	all	all	DT
cord-259603-bh198xgl	388	31	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	388	32	helicases	helicase	NNS
cord-259603-bh198xgl	388	33	tested	test	VBN
cord-259603-bh198xgl	388	34	thus	thus	RB
cord-259603-bh198xgl	388	35	far	far	RB
cord-259603-bh198xgl	388	36	and	and	CC
cord-259603-bh198xgl	388	37	,	,	,
cord-259603-bh198xgl	388	38	when	when	WRB
cord-259603-bh198xgl	388	39	introduced	introduce	VBN
cord-259603-bh198xgl	388	40	by	by	IN
cord-259603-bh198xgl	388	41	reverse	reverse	JJ
cord-259603-bh198xgl	388	42	genetics	genetic	NNS
cord-259603-bh198xgl	388	43	,	,	,
cord-259603-bh198xgl	388	44	this	this	DT
cord-259603-bh198xgl	388	45	mutation	mutation	NN
cord-259603-bh198xgl	388	46	also	also	RB
cord-259603-bh198xgl	388	47	abolished	abolish	VBD
cord-259603-bh198xgl	388	48	replication	replication	NN
cord-259603-bh198xgl	388	49	of	of	IN
cord-259603-bh198xgl	388	50	the	the	DT
cord-259603-bh198xgl	388	51	arterivirus	arterivirus	NNP
cord-259603-bh198xgl	388	52	EAV	EAV	NNP
cord-259603-bh198xgl	388	53	(	(	-LRB-
cord-259603-bh198xgl	388	54	Seybert	Seybert	NNP
cord-259603-bh198xgl	388	55	et	et	NNP
cord-259603-bh198xgl	388	56	al	al	NNP
cord-259603-bh198xgl	388	57	.	.	NNP
cord-259603-bh198xgl	388	58	,	,	,
cord-259603-bh198xgl	388	59	2000b	2000b	CD
cord-259603-bh198xgl	388	60	)	)	-RRB-
cord-259603-bh198xgl	388	61	.	.	.
cord-259603-bh198xgl	389	1	The	the	DT
cord-259603-bh198xgl	389	2	substrate	substrate	NN
cord-259603-bh198xgl	389	3	preferences	preference	NNS
cord-259603-bh198xgl	389	4	summarized	summarize	VBD
cord-259603-bh198xgl	389	5	earlier	early	JJR
cord-259603-bh198xgl	389	6	support	support	VBP
cord-259603-bh198xgl	389	7	a	a	DT
cord-259603-bh198xgl	389	8	threedimensional	threedimensional	JJ
cord-259603-bh198xgl	389	9	model	model	NN
cord-259603-bh198xgl	389	10	of	of	IN
cord-259603-bh198xgl	389	11	the	the	DT
cord-259603-bh198xgl	389	12	SARS	SARS	NNP
cord-259603-bh198xgl	389	13	-	-	HYPH
cord-259603-bh198xgl	389	14	CoV	CoV	NNP
cord-259603-bh198xgl	389	15	HEL1	HEL1	NNP
cord-259603-bh198xgl	389	16	core	core	NN
cord-259603-bh198xgl	389	17	domains	domain	NNS
cord-259603-bh198xgl	389	18	(	(	-LRB-
cord-259603-bh198xgl	389	19	1A	1a	NN
cord-259603-bh198xgl	389	20	and	and	CC
cord-259603-bh198xgl	389	21	2A	2a	LS
cord-259603-bh198xgl	389	22	)	)	-RRB-
cord-259603-bh198xgl	389	23	that	that	WDT
cord-259603-bh198xgl	389	24	was	be	VBD
cord-259603-bh198xgl	389	25	based	base	VBN
cord-259603-bh198xgl	389	26	on	on	IN
cord-259603-bh198xgl	389	27	structural	structural	JJ
cord-259603-bh198xgl	389	28	information	information	NN
cord-259603-bh198xgl	389	29	available	available	JJ
cord-259603-bh198xgl	389	30	for	for	IN
cord-259603-bh198xgl	389	31	multiple	multiple	JJ
cord-259603-bh198xgl	389	32	cellular	cellular	JJ
cord-259603-bh198xgl	389	33	helicases	helicase	NNS
cord-259603-bh198xgl	389	34	(	(	-LRB-
cord-259603-bh198xgl	389	35	Hoffmann	Hoffmann	NNP
cord-259603-bh198xgl	389	36	et	et	NNP
cord-259603-bh198xgl	389	37	al	al	NNP
cord-259603-bh198xgl	389	38	.	.	NNP
cord-259603-bh198xgl	389	39	,	,	,
cord-259603-bh198xgl	389	40	2006	2006	CD
cord-259603-bh198xgl	389	41	)	)	-RRB-
cord-259603-bh198xgl	389	42	.	.	.
cord-259603-bh198xgl	390	1	The	the	DT
cord-259603-bh198xgl	390	2	model	model	NN
cord-259603-bh198xgl	390	3	predicts	predict	VBZ
cord-259603-bh198xgl	390	4	both	both	CC
cord-259603-bh198xgl	390	5	the	the	DT
cord-259603-bh198xgl	390	6	existence	existence	NN
cord-259603-bh198xgl	390	7	of	of	IN
cord-259603-bh198xgl	390	8	multiple	multiple	JJ
cord-259603-bh198xgl	390	9	hydrogen	hydrogen	NN
cord-259603-bh198xgl	390	10	bonding	bonding	NN
cord-259603-bh198xgl	390	11	interactions	interaction	NNS
cord-259603-bh198xgl	390	12	with	with	IN
cord-259603-bh198xgl	390	13	the	the	DT
cord-259603-bh198xgl	390	14	βand	βand	NN
cord-259603-bh198xgl	390	15	γ	γ	NN
cord-259603-bh198xgl	390	16	-	-	:
cord-259603-bh198xgl	390	17	phosphates	phosphate	NNS
cord-259603-bh198xgl	390	18	of	of	IN
cord-259603-bh198xgl	390	19	the	the	DT
cord-259603-bh198xgl	390	20	NTP	NTP	NNP
cord-259603-bh198xgl	390	21	and	and	CC
cord-259603-bh198xgl	390	22	a	a	DT
cord-259603-bh198xgl	390	23	lack	lack	NN
cord-259603-bh198xgl	390	24	of	of	IN
cord-259603-bh198xgl	390	25	specific	specific	JJ
cord-259603-bh198xgl	390	26	interactions	interaction	NNS
cord-259603-bh198xgl	390	27	with	with	IN
cord-259603-bh198xgl	390	28	the	the	DT
cord-259603-bh198xgl	390	29	nucleobase	nucleobase	NN
cord-259603-bh198xgl	390	30	.	.	.
cord-259603-bh198xgl	391	1	Thus	thus	RB
cord-259603-bh198xgl	391	2	,	,	,
cord-259603-bh198xgl	391	3	the	the	DT
cord-259603-bh198xgl	391	4	mere	mere	JJ
cord-259603-bh198xgl	391	5	presence	presence	NN
cord-259603-bh198xgl	391	6	of	of	IN
cord-259603-bh198xgl	391	7	a	a	DT
cord-259603-bh198xgl	391	8	5	5	CD
cord-259603-bh198xgl	391	9	0	0	CD
cord-259603-bh198xgl	391	10	triphosphate	triphosphate	NN
cord-259603-bh198xgl	391	11	group	group	NN
cord-259603-bh198xgl	391	12	appears	appear	VBZ
cord-259603-bh198xgl	391	13	to	to	TO
cord-259603-bh198xgl	391	14	be	be	VB
cord-259603-bh198xgl	391	15	the	the	DT
cord-259603-bh198xgl	391	16	main	main	JJ
cord-259603-bh198xgl	391	17	determinant	determinant	NN
cord-259603-bh198xgl	391	18	for	for	IN
cord-259603-bh198xgl	391	19	NTP	NTP	NNP
cord-259603-bh198xgl	391	20	/	/	SYM
cord-259603-bh198xgl	391	21	dNTP	dntp	NN
cord-259603-bh198xgl	391	22	binding	binding	NN
cord-259603-bh198xgl	391	23	.	.	.
cord-259603-bh198xgl	392	1	Since	since	IN
cord-259603-bh198xgl	392	2	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	392	3	helicases	helicase	NNS
cord-259603-bh198xgl	392	4	are	be	VBP
cord-259603-bh198xgl	392	5	presumed	presume	VBN
cord-259603-bh198xgl	392	6	to	to	TO
cord-259603-bh198xgl	392	7	unwind	unwind	VB
cord-259603-bh198xgl	392	8	double	double	RB
cord-259603-bh198xgl	392	9	-	-	HYPH
cord-259603-bh198xgl	392	10	stranded	strand	VBN
cord-259603-bh198xgl	392	11	RNA	RNA	NNP
cord-259603-bh198xgl	392	12	intermediates	intermediate	NNS
cord-259603-bh198xgl	392	13	that	that	WDT
cord-259603-bh198xgl	392	14	are	be	VBP
cord-259603-bh198xgl	392	15	formed	form	VBN
cord-259603-bh198xgl	392	16	during	during	IN
cord-259603-bh198xgl	392	17	viral	viral	JJ
cord-259603-bh198xgl	392	18	replication	replication	NN
cord-259603-bh198xgl	392	19	,	,	,
cord-259603-bh198xgl	392	20	considerable	considerable	JJ
cord-259603-bh198xgl	392	21	attention	attention	NN
cord-259603-bh198xgl	392	22	was	be	VBD
cord-259603-bh198xgl	392	23	given	give	VBN
cord-259603-bh198xgl	392	24	to	to	IN
cord-259603-bh198xgl	392	25	the	the	DT
cord-259603-bh198xgl	392	26	in	in	FW
cord-259603-bh198xgl	392	27	vitro	vitro	FW
cord-259603-bh198xgl	392	28	characterization	characterization	NN
cord-259603-bh198xgl	392	29	of	of	IN
cord-259603-bh198xgl	392	30	their	-PRON-	PRP$
cord-259603-bh198xgl	392	31	nucleic	nucleic	JJ
cord-259603-bh198xgl	392	32	acid	acid	NN
cord-259603-bh198xgl	392	33	substrate	substrate	NN
cord-259603-bh198xgl	392	34	preferences	preference	NNS
cord-259603-bh198xgl	392	35	(	(	-LRB-
cord-259603-bh198xgl	392	36	Seybert	Seybert	NNP
cord-259603-bh198xgl	392	37	et	et	FW
cord-259603-bh198xgl	392	38	al	al	NNP
cord-259603-bh198xgl	392	39	.	.	NNP
cord-259603-bh198xgl	392	40	,	,	,
cord-259603-bh198xgl	392	41	2000a	2000a	CD
cord-259603-bh198xgl	392	42	,	,	,
cord-259603-bh198xgl	392	43	b	b	LS
cord-259603-bh198xgl	392	44	)	)	-RRB-
cord-259603-bh198xgl	392	45	.	.	.
cord-259603-bh198xgl	393	1	The	the	DT
cord-259603-bh198xgl	393	2	HCoV-229E	HCoV-229E	NNP
cord-259603-bh198xgl	393	3	and	and	CC
cord-259603-bh198xgl	393	4	EAV	EAV	NNP
cord-259603-bh198xgl	393	5	helicases	helicase	NNS
cord-259603-bh198xgl	393	6	could	could	MD
cord-259603-bh198xgl	393	7	not	not	RB
cord-259603-bh198xgl	393	8	unwind	unwind	VB
cord-259603-bh198xgl	393	9	substrates	substrate	NNS
cord-259603-bh198xgl	393	10	with	with	IN
cord-259603-bh198xgl	393	11	3	3	CD
cord-259603-bh198xgl	393	12	0	0	CD
cord-259603-bh198xgl	393	13	single	single	RB
cord-259603-bh198xgl	393	14	-	-	HYPH
cord-259603-bh198xgl	393	15	stranded	strand	VBN
cord-259603-bh198xgl	393	16	tails	tail	NNS
cord-259603-bh198xgl	393	17	or	or	CC
cord-259603-bh198xgl	393	18	blunt	blunt	RB
cord-259603-bh198xgl	393	19	-	-	HYPH
cord-259603-bh198xgl	393	20	ended	end	VBN
cord-259603-bh198xgl	393	21	substrates	substrate	NNS
cord-259603-bh198xgl	393	22	.	.	.
cord-259603-bh198xgl	394	1	In	in	IN
cord-259603-bh198xgl	394	2	contrast	contrast	NN
cord-259603-bh198xgl	394	3	,	,	,
cord-259603-bh198xgl	394	4	RNA	RNA	NNP
cord-259603-bh198xgl	394	5	and	and	CC
cord-259603-bh198xgl	394	6	DNA	dna	NN
cord-259603-bh198xgl	394	7	substrates	substrate	NNS
cord-259603-bh198xgl	394	8	with	with	IN
cord-259603-bh198xgl	394	9	one	one	CD
cord-259603-bh198xgl	394	10	or	or	CC
cord-259603-bh198xgl	394	11	two	two	CD
cord-259603-bh198xgl	394	12	5	5	CD
cord-259603-bh198xgl	394	13	0	0	CD
cord-259603-bh198xgl	394	14	single	single	RB
cord-259603-bh198xgl	394	15	-	-	HYPH
cord-259603-bh198xgl	394	16	stranded	strand	VBN
cord-259603-bh198xgl	394	17	regions	region	NNS
cord-259603-bh198xgl	394	18	were	be	VBD
cord-259603-bh198xgl	394	19	unwound	unwind	VBN
cord-259603-bh198xgl	394	20	efficiently	efficiently	RB
cord-259603-bh198xgl	394	21	,	,	,
cord-259603-bh198xgl	394	22	suggesting	suggest	VBG
cord-259603-bh198xgl	394	23	that	that	IN
cord-259603-bh198xgl	394	24	the	the	DT
cord-259603-bh198xgl	394	25	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	394	26	helicase	helicase	NNP
cord-259603-bh198xgl	394	27	must	must	MD
cord-259603-bh198xgl	394	28	bind	bind	VB
cord-259603-bh198xgl	394	29	to	to	IN
cord-259603-bh198xgl	394	30	a	a	DT
cord-259603-bh198xgl	394	31	single	single	RB
cord-259603-bh198xgl	394	32	-	-	HYPH
cord-259603-bh198xgl	394	33	stranded	strand	VBN
cord-259603-bh198xgl	394	34	region	region	NN
cord-259603-bh198xgl	394	35	before	before	IN
cord-259603-bh198xgl	394	36	initiating	initiate	VBG
cord-259603-bh198xgl	394	37	unwinding	unwind	VBG
cord-259603-bh198xgl	394	38	in	in	IN
cord-259603-bh198xgl	394	39	the	the	DT
cord-259603-bh198xgl	394	40	5	5	CD
cord-259603-bh198xgl	394	41	0	0	CD
cord-259603-bh198xgl	394	42	-to-3	-to-3	CD
cord-259603-bh198xgl	394	43	0	0	CD
cord-259603-bh198xgl	394	44	direction	direction	NN
cord-259603-bh198xgl	394	45	.	.	.
cord-259603-bh198xgl	395	1	However	however	RB
cord-259603-bh198xgl	395	2	,	,	,
cord-259603-bh198xgl	395	3	the	the	DT
cord-259603-bh198xgl	395	4	in	in	FW
cord-259603-bh198xgl	395	5	vitro	vitro	FW
cord-259603-bh198xgl	395	6	assays	assay	NNS
cord-259603-bh198xgl	395	7	did	do	VBD
cord-259603-bh198xgl	395	8	not	not	RB
cord-259603-bh198xgl	395	9	yield	yield	VB
cord-259603-bh198xgl	395	10	any	any	DT
cord-259603-bh198xgl	395	11	clear	clear	JJ
cord-259603-bh198xgl	395	12	indications	indication	NNS
cord-259603-bh198xgl	395	13	for	for	IN
cord-259603-bh198xgl	395	14	the	the	DT
cord-259603-bh198xgl	395	15	preferred	preferred	JJ
cord-259603-bh198xgl	395	16	recognition	recognition	NN
cord-259603-bh198xgl	395	17	of	of	IN
cord-259603-bh198xgl	395	18	specific	specific	JJ
cord-259603-bh198xgl	395	19	sequences	sequence	NNS
cord-259603-bh198xgl	395	20	or	or	CC
cord-259603-bh198xgl	395	21	higher	high	JJR
cord-259603-bh198xgl	395	22	-	-	HYPH
cord-259603-bh198xgl	395	23	order	order	NN
cord-259603-bh198xgl	395	24	structures	structure	NNS
cord-259603-bh198xgl	395	25	in	in	IN
cord-259603-bh198xgl	395	26	the	the	DT
cord-259603-bh198xgl	395	27	substrate	substrate	NN
cord-259603-bh198xgl	395	28	(	(	-LRB-
cord-259603-bh198xgl	395	29	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	395	30	et	et	NNP
cord-259603-bh198xgl	395	31	al	al	NNP
cord-259603-bh198xgl	395	32	.	.	NNP
cord-259603-bh198xgl	395	33	,	,	,
cord-259603-bh198xgl	395	34	2015c	2015c	CD
cord-259603-bh198xgl	395	35	)	)	-RRB-
cord-259603-bh198xgl	395	36	.	.	.
cord-259603-bh198xgl	396	1	Also	also	RB
cord-259603-bh198xgl	396	2	a	a	DT
cord-259603-bh198xgl	396	3	more	more	RBR
cord-259603-bh198xgl	396	4	in	in	IN
cord-259603-bh198xgl	396	5	-	-	HYPH
cord-259603-bh198xgl	396	6	depth	depth	NN
cord-259603-bh198xgl	396	7	biochemical	biochemical	JJ
cord-259603-bh198xgl	396	8	characterization	characterization	NN
cord-259603-bh198xgl	396	9	,	,	,
cord-259603-bh198xgl	396	10	performed	perform	VBN
cord-259603-bh198xgl	396	11	with	with	IN
cord-259603-bh198xgl	396	12	SARS	SARS	NNP
cord-259603-bh198xgl	396	13	-	-	HYPH
cord-259603-bh198xgl	396	14	CoV	CoV	NNP
cord-259603-bh198xgl	396	15	nsp13	nsp13	NNP
cord-259603-bh198xgl	396	16	,	,	,
cord-259603-bh198xgl	396	17	confirmed	confirm	VBD
cord-259603-bh198xgl	396	18	that	that	IN
cord-259603-bh198xgl	396	19	the	the	DT
cord-259603-bh198xgl	396	20	CoV	cov	NN
cord-259603-bh198xgl	396	21	helicase	helicase	NNP
cord-259603-bh198xgl	396	22	does	do	VBZ
cord-259603-bh198xgl	396	23	not	not	RB
cord-259603-bh198xgl	396	24	discriminate	discriminate	VB
cord-259603-bh198xgl	396	25	between	between	IN
cord-259603-bh198xgl	396	26	RNA	RNA	NNP
cord-259603-bh198xgl	396	27	and	and	CC
cord-259603-bh198xgl	396	28	DNA	dna	NN
cord-259603-bh198xgl	396	29	substrates	substrate	NNS
cord-259603-bh198xgl	396	30	(	(	-LRB-
cord-259603-bh198xgl	396	31	Adedeji	Adedeji	NNP
cord-259603-bh198xgl	396	32	et	et	NNP
cord-259603-bh198xgl	396	33	al	al	NNP
cord-259603-bh198xgl	396	34	.	.	NNP
cord-259603-bh198xgl	396	35	,	,	,
cord-259603-bh198xgl	396	36	2012a	2012a	CD
cord-259603-bh198xgl	396	37	)	)	-RRB-
cord-259603-bh198xgl	396	38	.	.	.
cord-259603-bh198xgl	397	1	Consequently	consequently	RB
cord-259603-bh198xgl	397	2	,	,	,
cord-259603-bh198xgl	397	3	it	-PRON-	PRP
cord-259603-bh198xgl	397	4	can	can	MD
cord-259603-bh198xgl	397	5	not	not	RB
cord-259603-bh198xgl	397	6	be	be	VB
cord-259603-bh198xgl	397	7	excluded	exclude	VBN
cord-259603-bh198xgl	397	8	that	that	IN
cord-259603-bh198xgl	397	9	the	the	DT
cord-259603-bh198xgl	397	10	enzyme	enzyme	NN
cord-259603-bh198xgl	397	11	,	,	,
cord-259603-bh198xgl	397	12	in	in	IN
cord-259603-bh198xgl	397	13	addition	addition	NN
cord-259603-bh198xgl	397	14	to	to	IN
cord-259603-bh198xgl	397	15	being	be	VBG
cord-259603-bh198xgl	397	16	engaged	engage	VBN
cord-259603-bh198xgl	397	17	in	in	IN
cord-259603-bh198xgl	397	18	viral	viral	JJ
cord-259603-bh198xgl	397	19	RNA	RNA	NNP
cord-259603-bh198xgl	397	20	synthesis	synthesis	NN
cord-259603-bh198xgl	397	21	,	,	,
cord-259603-bh198xgl	397	22	may	may	MD
cord-259603-bh198xgl	397	23	also	also	RB
cord-259603-bh198xgl	397	24	target	target	VB
cord-259603-bh198xgl	397	25	host	host	NN
cord-259603-bh198xgl	397	26	DNA	dna	NN
cord-259603-bh198xgl	397	27	.	.	.
cord-259603-bh198xgl	398	1	Nuclear	nuclear	JJ
cord-259603-bh198xgl	398	2	translocation	translocation	NN
cord-259603-bh198xgl	398	3	of	of	IN
cord-259603-bh198xgl	398	4	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	398	5	helicases	helicases	NNPS
cord-259603-bh198xgl	398	6	has	have	VBZ
cord-259603-bh198xgl	398	7	not	not	RB
cord-259603-bh198xgl	398	8	been	be	VBN
cord-259603-bh198xgl	398	9	reported	report	VBN
cord-259603-bh198xgl	398	10	thus	thus	RB
cord-259603-bh198xgl	398	11	far	far	RB
cord-259603-bh198xgl	398	12	,	,	,
cord-259603-bh198xgl	398	13	but	but	CC
cord-259603-bh198xgl	398	14	the	the	DT
cord-259603-bh198xgl	398	15	light	light	JJ
cord-259603-bh198xgl	398	16	microscopy	microscopy	NN
cord-259603-bh198xgl	398	17	techniques	technique	NNS
cord-259603-bh198xgl	398	18	used	use	VBN
cord-259603-bh198xgl	398	19	to	to	TO
cord-259603-bh198xgl	398	20	study	study	VB
cord-259603-bh198xgl	398	21	the	the	DT
cord-259603-bh198xgl	398	22	protein	protein	NN
cord-259603-bh198xgl	398	23	's	's	POS
cord-259603-bh198xgl	398	24	subcellular	subcellular	JJ
cord-259603-bh198xgl	398	25	distribution	distribution	NN
cord-259603-bh198xgl	398	26	would	would	MD
cord-259603-bh198xgl	398	27	not	not	RB
cord-259603-bh198xgl	398	28	suffice	suffice	VB
cord-259603-bh198xgl	398	29	to	to	TO
cord-259603-bh198xgl	398	30	detect	detect	VB
cord-259603-bh198xgl	398	31	the	the	DT
cord-259603-bh198xgl	398	32	nuclear	nuclear	JJ
cord-259603-bh198xgl	398	33	import	import	NN
cord-259603-bh198xgl	398	34	of	of	IN
cord-259603-bh198xgl	398	35	only	only	RB
cord-259603-bh198xgl	398	36	a	a	DT
cord-259603-bh198xgl	398	37	small	small	JJ
cord-259603-bh198xgl	398	38	fraction	fraction	NN
cord-259603-bh198xgl	398	39	of	of	IN
cord-259603-bh198xgl	398	40	the	the	DT
cord-259603-bh198xgl	398	41	protein	protein	NN
cord-259603-bh198xgl	398	42	.	.	.
cord-259603-bh198xgl	399	1	As	as	IN
cord-259603-bh198xgl	399	2	a	a	DT
cord-259603-bh198xgl	399	3	final	final	JJ
cord-259603-bh198xgl	399	4	caveat	caveat	NN
cord-259603-bh198xgl	399	5	it	-PRON-	PRP
cord-259603-bh198xgl	399	6	should	should	MD
cord-259603-bh198xgl	399	7	be	be	VB
cord-259603-bh198xgl	399	8	stressed	stress	VBN
cord-259603-bh198xgl	399	9	that	that	IN
cord-259603-bh198xgl	399	10	the	the	DT
cord-259603-bh198xgl	399	11	biochemical	biochemical	JJ
cord-259603-bh198xgl	399	12	properties	property	NNS
cord-259603-bh198xgl	399	13	summarized	summarize	VBD
cord-259603-bh198xgl	399	14	earlier	early	RBR
cord-259603-bh198xgl	399	15	are	be	VBP
cord-259603-bh198xgl	399	16	all	all	DT
cord-259603-bh198xgl	399	17	derived	derive	VBN
cord-259603-bh198xgl	399	18	from	from	IN
cord-259603-bh198xgl	399	19	in	in	IN
cord-259603-bh198xgl	399	20	vitro	vitro	FW
cord-259603-bh198xgl	399	21	studies	study	NNS
cord-259603-bh198xgl	399	22	using	use	VBG
cord-259603-bh198xgl	399	23	recombinant	recombinant	JJ
cord-259603-bh198xgl	399	24	helicases	helicase	NNS
cord-259603-bh198xgl	399	25	,	,	,
cord-259603-bh198xgl	399	26	expressed	express	VBN
cord-259603-bh198xgl	399	27	in	in	IN
cord-259603-bh198xgl	399	28	different	different	JJ
cord-259603-bh198xgl	399	29	systems	system	NNS
cord-259603-bh198xgl	399	30	and	and	CC
cord-259603-bh198xgl	399	31	sometimes	sometimes	RB
cord-259603-bh198xgl	399	32	containing	contain	VBG
cord-259603-bh198xgl	399	33	substantial	substantial	JJ
cord-259603-bh198xgl	399	34	foreign	foreign	JJ
cord-259603-bh198xgl	399	35	sequences	sequence	NNS
cord-259603-bh198xgl	399	36	.	.	.
cord-259603-bh198xgl	400	1	The	the	DT
cord-259603-bh198xgl	400	2	in	in	IN
cord-259603-bh198xgl	400	3	situ	situ	JJ
cord-259603-bh198xgl	400	4	characterization	characterization	NN
cord-259603-bh198xgl	400	5	of	of	IN
cord-259603-bh198xgl	400	6	the	the	DT
cord-259603-bh198xgl	400	7	helicase	helicase	NN
cord-259603-bh198xgl	400	8	as	as	IN
cord-259603-bh198xgl	400	9	one	one	CD
cord-259603-bh198xgl	400	10	of	of	IN
cord-259603-bh198xgl	400	11	the	the	DT
cord-259603-bh198xgl	400	12	key	key	JJ
cord-259603-bh198xgl	400	13	enzymes	enzyme	NNS
cord-259603-bh198xgl	400	14	of	of	IN
cord-259603-bh198xgl	400	15	the	the	DT
cord-259603-bh198xgl	400	16	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	400	17	RNA	RNA	NNP
cord-259603-bh198xgl	400	18	-	-	HYPH
cord-259603-bh198xgl	400	19	synthesizing	synthesize	VBG
cord-259603-bh198xgl	400	20	machinery	machinery	NN
cord-259603-bh198xgl	400	21	remains	remain	VBZ
cord-259603-bh198xgl	400	22	to	to	TO
cord-259603-bh198xgl	400	23	be	be	VB
cord-259603-bh198xgl	400	24	addressed	address	VBN
cord-259603-bh198xgl	400	25	.	.	.
cord-259603-bh198xgl	401	1	In	in	IN
cord-259603-bh198xgl	401	2	that	that	DT
cord-259603-bh198xgl	401	3	context	context	NN
cord-259603-bh198xgl	401	4	,	,	,
cord-259603-bh198xgl	401	5	sequence	sequence	NN
cord-259603-bh198xgl	401	6	specificity	specificity	NN
cord-259603-bh198xgl	401	7	,	,	,
cord-259603-bh198xgl	401	8	for	for	IN
cord-259603-bh198xgl	401	9	example	example	NN
cord-259603-bh198xgl	401	10	,	,	,
cord-259603-bh198xgl	401	11	could	could	MD
cord-259603-bh198xgl	401	12	be	be	VB
cord-259603-bh198xgl	401	13	conveyed	convey	VBN
cord-259603-bh198xgl	401	14	by	by	IN
cord-259603-bh198xgl	401	15	other	other	JJ
cord-259603-bh198xgl	401	16	subunits	subunit	NNS
cord-259603-bh198xgl	401	17	of	of	IN
cord-259603-bh198xgl	401	18	the	the	DT
cord-259603-bh198xgl	401	19	replicase	replicase	NN
cord-259603-bh198xgl	401	20	complex	complex	NN
cord-259603-bh198xgl	401	21	,	,	,
cord-259603-bh198xgl	401	22	which	which	WDT
cord-259603-bh198xgl	401	23	may	may	MD
cord-259603-bh198xgl	401	24	target	target	VB
cord-259603-bh198xgl	401	25	the	the	DT
cord-259603-bh198xgl	401	26	helicase	helicase	NN
cord-259603-bh198xgl	401	27	to	to	TO
cord-259603-bh198xgl	401	28	,	,	,
cord-259603-bh198xgl	401	29	e.g.	e.g.	RB
cord-259603-bh198xgl	401	30	,	,	,
cord-259603-bh198xgl	401	31	the	the	DT
cord-259603-bh198xgl	401	32	initiation	initiation	NN
cord-259603-bh198xgl	401	33	sites	site	NNS
cord-259603-bh198xgl	401	34	for	for	IN
cord-259603-bh198xgl	401	35	viral	viral	JJ
cord-259603-bh198xgl	401	36	genome	genome	NN
cord-259603-bh198xgl	401	37	or	or	CC
cord-259603-bh198xgl	401	38	antigenome	antigenome	NN
cord-259603-bh198xgl	401	39	synthesis	synthesis	NN
cord-259603-bh198xgl	401	40	,	,	,
cord-259603-bh198xgl	401	41	or	or	CC
cord-259603-bh198xgl	401	42	to	to	TO
cord-259603-bh198xgl	401	43	signals	signal	NNS
cord-259603-bh198xgl	401	44	controlling	control	VBG
cord-259603-bh198xgl	401	45	the	the	DT
cord-259603-bh198xgl	401	46	production	production	NN
cord-259603-bh198xgl	401	47	of	of	IN
cord-259603-bh198xgl	401	48	subgenomic	subgenomic	NNP
cord-259603-bh198xgl	401	49	mRNAs	mRNAs	NNPS
cord-259603-bh198xgl	401	50	.	.	.
cord-259603-bh198xgl	402	1	As	as	IN
cord-259603-bh198xgl	402	2	summarized	summarize	VBN
cord-259603-bh198xgl	402	3	by	by	IN
cord-259603-bh198xgl	402	4	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	402	5	et	et	NNP
cord-259603-bh198xgl	402	6	al	al	NNP
cord-259603-bh198xgl	402	7	.	.	.
cord-259603-bh198xgl	403	1	(	(	-LRB-
cord-259603-bh198xgl	403	2	2015c	2015c	CD
cord-259603-bh198xgl	403	3	)	)	-RRB-
cord-259603-bh198xgl	403	4	,	,	,
cord-259603-bh198xgl	403	5	other	other	JJ
cord-259603-bh198xgl	403	6	important	important	JJ
cord-259603-bh198xgl	403	7	helicase	helicase	NN
cord-259603-bh198xgl	403	8	features	feature	VBZ
cord-259603-bh198xgl	403	9	that	that	WDT
cord-259603-bh198xgl	403	10	could	could	MD
cord-259603-bh198xgl	403	11	be	be	VB
cord-259603-bh198xgl	403	12	dramatically	dramatically	RB
cord-259603-bh198xgl	403	13	different	different	JJ
cord-259603-bh198xgl	403	14	in	in	IN
cord-259603-bh198xgl	403	15	the	the	DT
cord-259603-bh198xgl	403	16	setting	setting	NN
cord-259603-bh198xgl	403	17	of	of	IN
cord-259603-bh198xgl	403	18	the	the	DT
cord-259603-bh198xgl	403	19	infected	infected	JJ
cord-259603-bh198xgl	403	20	cell	cell	NN
cord-259603-bh198xgl	403	21	are	be	VBP
cord-259603-bh198xgl	403	22	(	(	-LRB-
cord-259603-bh198xgl	403	23	the	the	DT
cord-259603-bh198xgl	403	24	need	need	NN
cord-259603-bh198xgl	403	25	for	for	IN
cord-259603-bh198xgl	403	26	)	)	-RRB-
cord-259603-bh198xgl	403	27	helicase	helicase	NNP
cord-259603-bh198xgl	403	28	oligomerization	oligomerization	NN
cord-259603-bh198xgl	403	29	,	,	,
cord-259603-bh198xgl	403	30	cooperativity	cooperativity	NN
cord-259603-bh198xgl	403	31	between	between	IN
cord-259603-bh198xgl	403	32	multiple	multiple	JJ
cord-259603-bh198xgl	403	33	helicase	helicase	NN
cord-259603-bh198xgl	403	34	molecules	molecule	NNS
cord-259603-bh198xgl	403	35	binding	bind	VBG
cord-259603-bh198xgl	403	36	to	to	IN
cord-259603-bh198xgl	403	37	the	the	DT
cord-259603-bh198xgl	403	38	same	same	JJ
cord-259603-bh198xgl	403	39	substrate	substrate	NN
cord-259603-bh198xgl	403	40	,	,	,
cord-259603-bh198xgl	403	41	and	and	CC
cord-259603-bh198xgl	403	42	-	-	HYPH
cord-259603-bh198xgl	403	43	consequentlythe	consequentlythe	DT
cord-259603-bh198xgl	403	44	overall	overall	JJ
cord-259603-bh198xgl	403	45	processivity	processivity	NN
cord-259603-bh198xgl	403	46	of	of	IN
cord-259603-bh198xgl	403	47	the	the	DT
cord-259603-bh198xgl	403	48	enzyme	enzyme	NN
cord-259603-bh198xgl	403	49	,	,	,
cord-259603-bh198xgl	403	50	which	which	WDT
cord-259603-bh198xgl	403	51	in	in	IN
cord-259603-bh198xgl	403	52	vitro	vitro	FW
cord-259603-bh198xgl	403	53	appeared	appear	VBD
cord-259603-bh198xgl	403	54	to	to	TO
cord-259603-bh198xgl	403	55	be	be	VB
cord-259603-bh198xgl	403	56	quite	quite	RB
cord-259603-bh198xgl	403	57	low	low	JJ
cord-259603-bh198xgl	403	58	given	give	VBN
cord-259603-bh198xgl	403	59	the	the	DT
cord-259603-bh198xgl	403	60	large	large	JJ
cord-259603-bh198xgl	403	61	CoV	cov	NN
cord-259603-bh198xgl	403	62	genome	genome	NN
cord-259603-bh198xgl	403	63	size	size	NN
cord-259603-bh198xgl	403	64	(	(	-LRB-
cord-259603-bh198xgl	403	65	Adedeji	Adedeji	NNP
cord-259603-bh198xgl	403	66	et	et	NNP
cord-259603-bh198xgl	403	67	al	al	NNP
cord-259603-bh198xgl	403	68	.	.	NNP
cord-259603-bh198xgl	403	69	,	,	,
cord-259603-bh198xgl	403	70	2012a	2012a	CD
cord-259603-bh198xgl	403	71	)	)	-RRB-
cord-259603-bh198xgl	403	72	.	.	.
cord-259603-bh198xgl	404	1	The	the	DT
cord-259603-bh198xgl	404	2	nidovirus	nidovirus	NN
cord-259603-bh198xgl	404	3	helicase	helicase	NNP
cord-259603-bh198xgl	404	4	subunit	subunit	NN
cord-259603-bh198xgl	404	5	domain	domain	NN
cord-259603-bh198xgl	404	6	is	be	VBZ
cord-259603-bh198xgl	404	7	unique	unique	JJ
cord-259603-bh198xgl	404	8	among	among	IN
cord-259603-bh198xgl	404	9	its	-PRON-	PRP$
cord-259603-bh198xgl	404	10	+	+	SYM
cord-259603-bh198xgl	404	11	RNA	RNA	NNP
cord-259603-bh198xgl	404	12	virus	virus	NN
cord-259603-bh198xgl	404	13	homologs	homolog	NNS
cord-259603-bh198xgl	404	14	in	in	IN
cord-259603-bh198xgl	404	15	having	have	VBG
cord-259603-bh198xgl	404	16	a	a	DT
cord-259603-bh198xgl	404	17	conserved	conserve	VBN
cord-259603-bh198xgl	404	18	N	n	CD
cord-259603-bh198xgl	404	19	-	-	HYPH
cord-259603-bh198xgl	404	20	terminal	terminal	NN
cord-259603-bh198xgl	404	21	domain	domain	NN
cord-259603-bh198xgl	404	22	of	of	IN
cord-259603-bh198xgl	404	23	80	80	CD
cord-259603-bh198xgl	404	24	-	-	SYM
cord-259603-bh198xgl	404	25	100	100	CD
cord-259603-bh198xgl	404	26	residues	residue	NNS
cord-259603-bh198xgl	404	27	that	that	WDT
cord-259603-bh198xgl	404	28	contains	contain	VBZ
cord-259603-bh198xgl	404	29	12	12	CD
cord-259603-bh198xgl	404	30	or	or	CC
cord-259603-bh198xgl	404	31	13	13	CD
cord-259603-bh198xgl	404	32	conserved	conserve	VBN
cord-259603-bh198xgl	404	33	Cys	Cys	NNP
cord-259603-bh198xgl	404	34	/	/	SYM
cord-259603-bh198xgl	404	35	His	-PRON-	PRP$
cord-259603-bh198xgl	404	36	residues	residue	NNS
cord-259603-bh198xgl	404	37	(	(	-LRB-
cord-259603-bh198xgl	404	38	den	den	NNP
cord-259603-bh198xgl	404	39	Boon	Boon	NNP
cord-259603-bh198xgl	404	40	et	et	NNP
cord-259603-bh198xgl	404	41	al	al	NNP
cord-259603-bh198xgl	404	42	.	.	NNP
cord-259603-bh198xgl	404	43	,	,	,
cord-259603-bh198xgl	404	44	1991	1991	CD
cord-259603-bh198xgl	404	45	;	;	:
cord-259603-bh198xgl	404	46	van	van	NNP
cord-259603-bh198xgl	404	47	Dinten	Dinten	NNP
cord-259603-bh198xgl	404	48	et	et	FW
cord-259603-bh198xgl	404	49	al	al	NNP
cord-259603-bh198xgl	404	50	.	.	NNP
cord-259603-bh198xgl	404	51	,	,	,
cord-259603-bh198xgl	404	52	2000	2000	CD
cord-259603-bh198xgl	404	53	)	)	-RRB-
cord-259603-bh198xgl	404	54	.	.	.
cord-259603-bh198xgl	405	1	The	the	DT
cord-259603-bh198xgl	405	2	domain	domain	NN
cord-259603-bh198xgl	405	3	was	be	VBD
cord-259603-bh198xgl	405	4	recognized	recognize	VBN
cord-259603-bh198xgl	405	5	as	as	IN
cord-259603-bh198xgl	405	6	a	a	DT
cord-259603-bh198xgl	405	7	potential	potential	JJ
cord-259603-bh198xgl	405	8	ZBD	ZBD	NNP
cord-259603-bh198xgl	405	9	(	(	-LRB-
cord-259603-bh198xgl	405	10	Gorbalenya	Gorbalenya	NNP
cord-259603-bh198xgl	405	11	et	et	NNP
cord-259603-bh198xgl	405	12	al	al	NNP
cord-259603-bh198xgl	405	13	.	.	NNP
cord-259603-bh198xgl	405	14	,	,	,
cord-259603-bh198xgl	405	15	1989	1989	CD
cord-259603-bh198xgl	405	16	)	)	-RRB-
cord-259603-bh198xgl	405	17	and	and	CC
cord-259603-bh198xgl	405	18	early	early	RB
cord-259603-bh198xgl	405	19	in	in	IN
cord-259603-bh198xgl	405	20	vitro	vitro	FW
cord-259603-bh198xgl	405	21	studies	study	NNS
cord-259603-bh198xgl	405	22	with	with	IN
cord-259603-bh198xgl	405	23	the	the	DT
cord-259603-bh198xgl	405	24	recombinant	recombinant	JJ
cord-259603-bh198xgl	405	25	HCoV-229E	HCoV-229E	NNP
cord-259603-bh198xgl	405	26	and	and	CC
cord-259603-bh198xgl	405	27	EAV	EAV	NNP
cord-259603-bh198xgl	405	28	helicases	helicases	NNPS
cord-259603-bh198xgl	405	29	confirmed	confirm	VBD
cord-259603-bh198xgl	405	30	that	that	IN
cord-259603-bh198xgl	405	31	Zn	Zn	NNP
cord-259603-bh198xgl	405	32	2	2	CD
cord-259603-bh198xgl	405	33	+	+	SYM
cord-259603-bh198xgl	405	34	ions	ion	NNS
cord-259603-bh198xgl	405	35	are	be	VBP
cord-259603-bh198xgl	405	36	essential	essential	JJ
cord-259603-bh198xgl	405	37	for	for	IN
cord-259603-bh198xgl	405	38	retaining	retain	VBG
cord-259603-bh198xgl	405	39	the	the	DT
cord-259603-bh198xgl	405	40	protein	protein	NN
cord-259603-bh198xgl	405	41	's	's	POS
cord-259603-bh198xgl	405	42	enzymatic	enzymatic	JJ
cord-259603-bh198xgl	405	43	activities	activity	NNS
cord-259603-bh198xgl	405	44	,	,	,
cord-259603-bh198xgl	405	45	suggesting	suggest	VBG
cord-259603-bh198xgl	405	46	that	that	IN
cord-259603-bh198xgl	405	47	ZBD	ZBD	NNP
cord-259603-bh198xgl	405	48	modulates	modulate	VBZ
cord-259603-bh198xgl	405	49	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	405	50	helicase	helicase	NNP
cord-259603-bh198xgl	405	51	function	function	NN
cord-259603-bh198xgl	405	52	(	(	-LRB-
cord-259603-bh198xgl	405	53	Seybert	Seybert	NNP
cord-259603-bh198xgl	405	54	et	et	FW
cord-259603-bh198xgl	405	55	al	al	NNP
cord-259603-bh198xgl	405	56	.	.	NNP
cord-259603-bh198xgl	405	57	,	,	,
cord-259603-bh198xgl	405	58	2005	2005	CD
cord-259603-bh198xgl	405	59	)	)	-RRB-
cord-259603-bh198xgl	405	60	.	.	.
cord-259603-bh198xgl	406	1	A	a	DT
cord-259603-bh198xgl	406	2	recent	recent	JJ
cord-259603-bh198xgl	406	3	structural	structural	JJ
cord-259603-bh198xgl	406	4	study	study	NN
cord-259603-bh198xgl	406	5	of	of	IN
cord-259603-bh198xgl	406	6	the	the	DT
cord-259603-bh198xgl	406	7	arterivirus	arterivirus	NNP
cord-259603-bh198xgl	406	8	nsp10-helicase	nsp10-helicase	NNP
cord-259603-bh198xgl	407	1	(	(	-LRB-
cord-259603-bh198xgl	407	2	Deng	Deng	NNP
cord-259603-bh198xgl	407	3	et	et	FW
cord-259603-bh198xgl	407	4	al	al	NNP
cord-259603-bh198xgl	407	5	.	.	.
cord-259603-bh198xgl	408	1	,	,	,
cord-259603-bh198xgl	408	2	2014	2014	CD
cord-259603-bh198xgl	408	3	)	)	-RRB-
cord-259603-bh198xgl	408	4	will	will	MD
cord-259603-bh198xgl	408	5	be	be	VB
cord-259603-bh198xgl	408	6	discussed	discuss	VBN
cord-259603-bh198xgl	408	7	in	in	IN
cord-259603-bh198xgl	408	8	more	more	JJR
cord-259603-bh198xgl	408	9	detail	detail	NN
cord-259603-bh198xgl	408	10	later	later	RB
cord-259603-bh198xgl	408	11	.	.	.
cord-259603-bh198xgl	409	1	This	this	DT
cord-259603-bh198xgl	409	2	first	first	JJ
cord-259603-bh198xgl	409	3	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	409	4	helicase	helicase	NNP
cord-259603-bh198xgl	409	5	structure	structure	NN
cord-259603-bh198xgl	409	6	confirmed	confirm	VBD
cord-259603-bh198xgl	409	7	the	the	DT
cord-259603-bh198xgl	409	8	binding	binding	NN
cord-259603-bh198xgl	409	9	of	of	IN
cord-259603-bh198xgl	409	10	three	three	CD
cord-259603-bh198xgl	409	11	zinc	zinc	NN
cord-259603-bh198xgl	409	12	ions	ion	NNS
cord-259603-bh198xgl	409	13	by	by	IN
cord-259603-bh198xgl	409	14	the	the	DT
cord-259603-bh198xgl	409	15	ZBD	ZBD	NNP
cord-259603-bh198xgl	409	16	,	,	,
cord-259603-bh198xgl	409	17	which	which	WDT
cord-259603-bh198xgl	409	18	adopts	adopt	VBZ
cord-259603-bh198xgl	409	19	a	a	DT
cord-259603-bh198xgl	409	20	unique	unique	JJ
cord-259603-bh198xgl	409	21	fold	fold	NN
cord-259603-bh198xgl	409	22	that	that	WDT
cord-259603-bh198xgl	409	23	combines	combine	VBZ
cord-259603-bh198xgl	409	24	a	a	DT
cord-259603-bh198xgl	409	25	RING	ring	NN
cord-259603-bh198xgl	409	26	-	-	HYPH
cord-259603-bh198xgl	409	27	like	like	JJ
cord-259603-bh198xgl	409	28	module	module	NN
cord-259603-bh198xgl	409	29	with	with	IN
cord-259603-bh198xgl	409	30	a	a	DT
cord-259603-bh198xgl	409	31	so	so	RB
cord-259603-bh198xgl	409	32	-	-	HYPH
cord-259603-bh198xgl	409	33	called	call	VBN
cord-259603-bh198xgl	409	34	"	"	``
cord-259603-bh198xgl	409	35	treble	treble	JJ
cord-259603-bh198xgl	409	36	-	-	HYPH
cord-259603-bh198xgl	409	37	clef	clef	NN
cord-259603-bh198xgl	409	38	"	"	''
cord-259603-bh198xgl	409	39	zinc	zinc	NN
cord-259603-bh198xgl	409	40	finger	finger	NN
cord-259603-bh198xgl	409	41	.	.	.
cord-259603-bh198xgl	410	1	ZBD	ZBD	NNP
cord-259603-bh198xgl	410	2	and	and	CC
cord-259603-bh198xgl	410	3	HEL1	HEL1	NNP
cord-259603-bh198xgl	410	4	interact	interact	VB
cord-259603-bh198xgl	410	5	extensively	extensively	RB
cord-259603-bh198xgl	410	6	(	(	-LRB-
cord-259603-bh198xgl	411	1	Deng	Deng	NNP
cord-259603-bh198xgl	411	2	et	et	NNP
cord-259603-bh198xgl	411	3	al	al	NNP
cord-259603-bh198xgl	411	4	.	.	.
cord-259603-bh198xgl	412	1	,	,	,
cord-259603-bh198xgl	412	2	2014	2014	CD
cord-259603-bh198xgl	412	3	)	)	-RRB-
cord-259603-bh198xgl	413	1	but	but	CC
cord-259603-bh198xgl	413	2	,	,	,
cord-259603-bh198xgl	413	3	in	in	IN
cord-259603-bh198xgl	413	4	the	the	DT
cord-259603-bh198xgl	413	5	helicase	helicase	NN
cord-259603-bh198xgl	413	6	primary	primary	JJ
cord-259603-bh198xgl	413	7	structure	structure	NN
cord-259603-bh198xgl	413	8	,	,	,
cord-259603-bh198xgl	413	9	they	-PRON-	PRP
cord-259603-bh198xgl	413	10	are	be	VBP
cord-259603-bh198xgl	413	11	separated	separate	VBN
cord-259603-bh198xgl	413	12	by	by	IN
cord-259603-bh198xgl	413	13	a	a	DT
cord-259603-bh198xgl	413	14	variable	variable	JJ
cord-259603-bh198xgl	413	15	and	and	CC
cord-259603-bh198xgl	413	16	uncharacterized	uncharacterized	JJ
cord-259603-bh198xgl	413	17	domain	domain	NN
cord-259603-bh198xgl	413	18	that	that	WDT
cord-259603-bh198xgl	413	19	essentially	essentially	RB
cord-259603-bh198xgl	413	20	explains	explain	VBZ
cord-259603-bh198xgl	413	21	the	the	DT
cord-259603-bh198xgl	413	22	size	size	NN
cord-259603-bh198xgl	413	23	difference	difference	NN
cord-259603-bh198xgl	413	24	of	of	IN
cord-259603-bh198xgl	413	25	about	about	IN
cord-259603-bh198xgl	413	26	130	130	CD
cord-259603-bh198xgl	413	27	residues	residue	NNS
cord-259603-bh198xgl	413	28	between	between	IN
cord-259603-bh198xgl	413	29	CoV	CoV	NNP
cord-259603-bh198xgl	413	30	and	and	CC
cord-259603-bh198xgl	413	31	arterivirus	arterivirus	NNP
cord-259603-bh198xgl	413	32	helicase	helicase	NNP
cord-259603-bh198xgl	413	33	subunits	subunit	NNS
cord-259603-bh198xgl	413	34	(	(	-LRB-
cord-259603-bh198xgl	413	35	Seybert	Seybert	NNP
cord-259603-bh198xgl	413	36	et	et	FW
cord-259603-bh198xgl	413	37	al	al	NNP
cord-259603-bh198xgl	413	38	.	.	NNP
cord-259603-bh198xgl	413	39	,	,	,
cord-259603-bh198xgl	413	40	2005	2005	CD
cord-259603-bh198xgl	413	41	)	)	-RRB-
cord-259603-bh198xgl	413	42	.	.	.
cord-259603-bh198xgl	414	1	Using	use	VBG
cord-259603-bh198xgl	414	2	the	the	DT
cord-259603-bh198xgl	414	3	arterivirus	arterivirus	NNP
cord-259603-bh198xgl	414	4	prototype	prototype	NN
cord-259603-bh198xgl	414	5	EAV	EAV	NNP
cord-259603-bh198xgl	414	6	,	,	,
cord-259603-bh198xgl	414	7	the	the	DT
cord-259603-bh198xgl	414	8	functional	functional	JJ
cord-259603-bh198xgl	414	9	importance	importance	NN
cord-259603-bh198xgl	414	10	of	of	IN
cord-259603-bh198xgl	414	11	ZBD	ZBD	NNP
cord-259603-bh198xgl	414	12	was	be	VBD
cord-259603-bh198xgl	414	13	probed	probe	VBN
cord-259603-bh198xgl	414	14	extensively	extensively	RB
cord-259603-bh198xgl	414	15	by	by	IN
cord-259603-bh198xgl	414	16	combining	combine	VBG
cord-259603-bh198xgl	414	17	biochemistry	biochemistry	NN
cord-259603-bh198xgl	414	18	and	and	CC
cord-259603-bh198xgl	414	19	reverse	reverse	VB
cord-259603-bh198xgl	414	20	genetics	genetic	NNS
cord-259603-bh198xgl	414	21	(	(	-LRB-
cord-259603-bh198xgl	414	22	Seybert	Seybert	NNP
cord-259603-bh198xgl	414	23	et	et	FW
cord-259603-bh198xgl	414	24	al	al	NNP
cord-259603-bh198xgl	414	25	.	.	NNP
cord-259603-bh198xgl	414	26	,	,	,
cord-259603-bh198xgl	414	27	2005	2005	CD
cord-259603-bh198xgl	414	28	;	;	:
cord-259603-bh198xgl	414	29	van	van	NNP
cord-259603-bh198xgl	414	30	Dinten	Dinten	NNP
cord-259603-bh198xgl	414	31	et	et	FW
cord-259603-bh198xgl	414	32	al	al	NNP
cord-259603-bh198xgl	414	33	.	.	NNP
cord-259603-bh198xgl	414	34	,	,	,
cord-259603-bh198xgl	414	35	2000	2000	CD
cord-259603-bh198xgl	414	36	)	)	-RRB-
cord-259603-bh198xgl	414	37	.	.	.
cord-259603-bh198xgl	415	1	This	this	DT
cord-259603-bh198xgl	415	2	yielded	yield	VBD
cord-259603-bh198xgl	415	3	a	a	DT
cord-259603-bh198xgl	415	4	variety	variety	NN
cord-259603-bh198xgl	415	5	of	of	IN
cord-259603-bh198xgl	415	6	phenotypes	phenotype	NNS
cord-259603-bh198xgl	415	7	for	for	IN
cord-259603-bh198xgl	415	8	nsp10-ZBD	nsp10-ZBD	NNP
cord-259603-bh198xgl	415	9	mutants	mutant	NNS
cord-259603-bh198xgl	415	10	,	,	,
cord-259603-bh198xgl	415	11	the	the	DT
cord-259603-bh198xgl	415	12	most	most	RBS
cord-259603-bh198xgl	415	13	striking	striking	JJ
cord-259603-bh198xgl	415	14	being	be	VBG
cord-259603-bh198xgl	415	15	mutants	mutant	NNS
cord-259603-bh198xgl	415	16	deficient	deficient	JJ
cord-259603-bh198xgl	415	17	in	in	IN
cord-259603-bh198xgl	415	18	subgenomic	subgenomic	NNP
cord-259603-bh198xgl	415	19	mRNA	mRNA	NNP
cord-259603-bh198xgl	415	20	synthesis	synthesis	NN
cord-259603-bh198xgl	415	21	while	while	IN
cord-259603-bh198xgl	415	22	remaining	remain	VBG
cord-259603-bh198xgl	415	23	capable	capable	JJ
cord-259603-bh198xgl	415	24	of	of	IN
cord-259603-bh198xgl	415	25	(	(	-LRB-
cord-259603-bh198xgl	415	26	and	and	CC
cord-259603-bh198xgl	415	27	even	even	RB
cord-259603-bh198xgl	415	28	enhancing	enhance	VBG
cord-259603-bh198xgl	415	29	)	)	-RRB-
cord-259603-bh198xgl	415	30	viral	viral	JJ
cord-259603-bh198xgl	415	31	genome	genome	NN
cord-259603-bh198xgl	415	32	replication	replication	NN
cord-259603-bh198xgl	415	33	(	(	-LRB-
cord-259603-bh198xgl	415	34	van	van	NNP
cord-259603-bh198xgl	415	35	Dinten	Dinten	NNP
cord-259603-bh198xgl	415	36	et	et	FW
cord-259603-bh198xgl	415	37	al	al	NNP
cord-259603-bh198xgl	415	38	.	.	NNP
cord-259603-bh198xgl	415	39	,	,	,
cord-259603-bh198xgl	415	40	1997	1997	CD
cord-259603-bh198xgl	415	41	(	(	-LRB-
cord-259603-bh198xgl	415	42	van	van	NNP
cord-259603-bh198xgl	415	43	Dinten	Dinten	NNP
cord-259603-bh198xgl	415	44	et	et	FW
cord-259603-bh198xgl	415	45	al	al	NNP
cord-259603-bh198xgl	415	46	.	.	NNP
cord-259603-bh198xgl	415	47	,	,	,
cord-259603-bh198xgl	415	48	,	,	,
cord-259603-bh198xgl	415	49	2000	2000	CD
cord-259603-bh198xgl	415	50	(	(	-LRB-
cord-259603-bh198xgl	415	51	see	see	VB
cord-259603-bh198xgl	415	52	later	later	RB
cord-259603-bh198xgl	415	53	)	)	-RRB-
cord-259603-bh198xgl	415	54	.	.	.
cord-259603-bh198xgl	416	1	Most	Most	JJS
cord-259603-bh198xgl	416	2	replacements	replacement	NNS
cord-259603-bh198xgl	416	3	of	of	IN
cord-259603-bh198xgl	416	4	conserved	conserve	VBN
cord-259603-bh198xgl	416	5	ZBD	ZBD	NNP
cord-259603-bh198xgl	416	6	Cys	Cys	NNP
cord-259603-bh198xgl	416	7	and	and	CC
cord-259603-bh198xgl	416	8	His	-PRON-	PRP$
cord-259603-bh198xgl	416	9	residues	residue	NNS
cord-259603-bh198xgl	416	10	profoundly	profoundly	RB
cord-259603-bh198xgl	416	11	impacted	impact	VBD
cord-259603-bh198xgl	416	12	the	the	DT
cord-259603-bh198xgl	416	13	helicase	helicase	NN
cord-259603-bh198xgl	416	14	activity	activity	NN
cord-259603-bh198xgl	416	15	of	of	IN
cord-259603-bh198xgl	416	16	EAV	EAV	NNP
cord-259603-bh198xgl	416	17	nsp10	nsp10	RB
cord-259603-bh198xgl	416	18	,	,	,
cord-259603-bh198xgl	416	19	even	even	RB
cord-259603-bh198xgl	416	20	when	when	WRB
cord-259603-bh198xgl	416	21	performed	perform	VBN
cord-259603-bh198xgl	416	22	in	in	IN
cord-259603-bh198xgl	416	23	a	a	DT
cord-259603-bh198xgl	416	24	semiconservative	semiconservative	JJ
cord-259603-bh198xgl	416	25	manner	manner	NN
cord-259603-bh198xgl	416	26	that	that	WDT
cord-259603-bh198xgl	416	27	could	could	MD
cord-259603-bh198xgl	416	28	preserve	preserve	VB
cord-259603-bh198xgl	416	29	zinc	zinc	NN
cord-259603-bh198xgl	416	30	binding	bind	VBG
cord-259603-bh198xgl	416	31	.	.	.
cord-259603-bh198xgl	417	1	In	in	IN
cord-259603-bh198xgl	417	2	reverse	reverse	JJ
cord-259603-bh198xgl	417	3	-	-	HYPH
cord-259603-bh198xgl	417	4	genetics	genetics	NN
cord-259603-bh198xgl	417	5	studies	study	NNS
cord-259603-bh198xgl	417	6	,	,	,
cord-259603-bh198xgl	417	7	most	most	JJS
cord-259603-bh198xgl	417	8	of	of	IN
cord-259603-bh198xgl	417	9	these	these	DT
cord-259603-bh198xgl	417	10	ZBD	ZBD	NNP
cord-259603-bh198xgl	417	11	mutations	mutation	NNS
cord-259603-bh198xgl	417	12	rendered	render	VBD
cord-259603-bh198xgl	417	13	the	the	DT
cord-259603-bh198xgl	417	14	virus	virus	NN
cord-259603-bh198xgl	417	15	nonviable	nonviable	JJ
cord-259603-bh198xgl	417	16	.	.	.
cord-259603-bh198xgl	418	1	Recently	recently	RB
cord-259603-bh198xgl	418	2	,	,	,
cord-259603-bh198xgl	418	3	the	the	DT
cord-259603-bh198xgl	418	4	impact	impact	NN
cord-259603-bh198xgl	418	5	of	of	IN
cord-259603-bh198xgl	418	6	these	these	DT
cord-259603-bh198xgl	418	7	mutations	mutation	NNS
cord-259603-bh198xgl	418	8	on	on	IN
cord-259603-bh198xgl	418	9	ZBD	ZBD	NNP
cord-259603-bh198xgl	418	10	integrity	integrity	NN
cord-259603-bh198xgl	418	11	and	and	CC
cord-259603-bh198xgl	418	12	ZBD	ZBD	NNP
cord-259603-bh198xgl	418	13	-	-	HYPH
cord-259603-bh198xgl	418	14	HEL1	HEL1	NNP
cord-259603-bh198xgl	418	15	interactions	interaction	NNS
cord-259603-bh198xgl	418	16	could	could	MD
cord-259603-bh198xgl	418	17	be	be	VB
cord-259603-bh198xgl	418	18	rationalized	rationalize	VBN
cord-259603-bh198xgl	418	19	with	with	IN
cord-259603-bh198xgl	418	20	the	the	DT
cord-259603-bh198xgl	418	21	help	help	NN
cord-259603-bh198xgl	418	22	of	of	IN
cord-259603-bh198xgl	418	23	the	the	DT
cord-259603-bh198xgl	418	24	nsp10	nsp10	NNP
cord-259603-bh198xgl	418	25	crystal	crystal	NN
cord-259603-bh198xgl	418	26	structure	structure	NN
cord-259603-bh198xgl	418	27	(	(	-LRB-
cord-259603-bh198xgl	418	28	Deng	Deng	NNP
cord-259603-bh198xgl	418	29	et	et	FW
cord-259603-bh198xgl	418	30	al	al	NNP
cord-259603-bh198xgl	418	31	.	.	NNP
cord-259603-bh198xgl	418	32	,	,	,
cord-259603-bh198xgl	418	33	2014	2014	CD
cord-259603-bh198xgl	418	34	)	)	-RRB-
cord-259603-bh198xgl	418	35	.	.	.
cord-259603-bh198xgl	419	1	Despite	despite	IN
cord-259603-bh198xgl	419	2	its	-PRON-	PRP$
cord-259603-bh198xgl	419	3	importance	importance	NN
cord-259603-bh198xgl	419	4	as	as	IN
cord-259603-bh198xgl	419	5	a	a	DT
cord-259603-bh198xgl	419	6	potential	potential	JJ
cord-259603-bh198xgl	419	7	drug	drug	NN
cord-259603-bh198xgl	419	8	target	target	NN
cord-259603-bh198xgl	419	9	,	,	,
cord-259603-bh198xgl	419	10	a	a	DT
cord-259603-bh198xgl	419	11	CoV	cov	NN
cord-259603-bh198xgl	419	12	nsp13	nsp13	NNP
cord-259603-bh198xgl	419	13	or	or	CC
cord-259603-bh198xgl	419	14	HEL1	HEL1	NNP
cord-259603-bh198xgl	419	15	crystal	crystal	NN
cord-259603-bh198xgl	419	16	structure	structure	NN
cord-259603-bh198xgl	419	17	has	have	VBZ
cord-259603-bh198xgl	419	18	not	not	RB
cord-259603-bh198xgl	419	19	been	be	VBN
cord-259603-bh198xgl	419	20	obtained	obtain	VBN
cord-259603-bh198xgl	419	21	thus	thus	RB
cord-259603-bh198xgl	419	22	far	far	RB
cord-259603-bh198xgl	419	23	due	due	JJ
cord-259603-bh198xgl	419	24	to	to	IN
cord-259603-bh198xgl	419	25	technical	technical	JJ
cord-259603-bh198xgl	419	26	complications	complication	NNS
cord-259603-bh198xgl	419	27	with	with	IN
cord-259603-bh198xgl	419	28	recombinant	recombinant	JJ
cord-259603-bh198xgl	419	29	protein	protein	NN
cord-259603-bh198xgl	419	30	production	production	NN
cord-259603-bh198xgl	419	31	and	and	CC
cord-259603-bh198xgl	419	32	crystallization	crystallization	NN
cord-259603-bh198xgl	419	33	.	.	.
cord-259603-bh198xgl	420	1	Instead	instead	RB
cord-259603-bh198xgl	420	2	,	,	,
cord-259603-bh198xgl	420	3	several	several	JJ
cord-259603-bh198xgl	420	4	CoV	cov	NN
cord-259603-bh198xgl	420	5	helicase	helicase	NN
cord-259603-bh198xgl	420	6	models	model	NNS
cord-259603-bh198xgl	420	7	have	have	VBP
cord-259603-bh198xgl	420	8	been	be	VBN
cord-259603-bh198xgl	420	9	described	describe	VBN
cord-259603-bh198xgl	420	10	,	,	,
cord-259603-bh198xgl	420	11	mainly	mainly	RB
cord-259603-bh198xgl	420	12	based	base	VBN
cord-259603-bh198xgl	420	13	on	on	IN
cord-259603-bh198xgl	420	14	cellular	cellular	JJ
cord-259603-bh198xgl	420	15	helicase	helicase	NN
cord-259603-bh198xgl	420	16	structures	structure	NNS
cord-259603-bh198xgl	420	17	(	(	-LRB-
cord-259603-bh198xgl	420	18	Bernini	Bernini	NNP
cord-259603-bh198xgl	420	19	et	et	NNP
cord-259603-bh198xgl	420	20	al	al	NNP
cord-259603-bh198xgl	420	21	.	.	NNP
cord-259603-bh198xgl	420	22	,	,	,
cord-259603-bh198xgl	420	23	2006	2006	CD
cord-259603-bh198xgl	420	24	;	;	:
cord-259603-bh198xgl	420	25	Hoffmann	Hoffmann	NNP
cord-259603-bh198xgl	420	26	et	et	NNP
cord-259603-bh198xgl	420	27	al	al	NNP
cord-259603-bh198xgl	420	28	.	.	NNP
cord-259603-bh198xgl	420	29	,	,	,
cord-259603-bh198xgl	420	30	2006	2006	CD
cord-259603-bh198xgl	420	31	;	;	:
cord-259603-bh198xgl	420	32	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	420	33	et	et	NNP
cord-259603-bh198xgl	420	34	al	al	NNP
cord-259603-bh198xgl	420	35	.	.	NNP
cord-259603-bh198xgl	420	36	,	,	,
cord-259603-bh198xgl	420	37	2015c	2015c	CD
cord-259603-bh198xgl	420	38	)	)	-RRB-
cord-259603-bh198xgl	420	39	.	.	.
cord-259603-bh198xgl	421	1	Given	give	VBN
cord-259603-bh198xgl	421	2	this	this	DT
cord-259603-bh198xgl	421	3	limitation	limitation	NN
cord-259603-bh198xgl	421	4	,	,	,
cord-259603-bh198xgl	421	5	and	and	CC
cord-259603-bh198xgl	421	6	despite	despite	IN
cord-259603-bh198xgl	421	7	the	the	DT
cord-259603-bh198xgl	421	8	large	large	JJ
cord-259603-bh198xgl	421	9	evolutionary	evolutionary	JJ
cord-259603-bh198xgl	421	10	distance	distance	NN
cord-259603-bh198xgl	421	11	between	between	IN
cord-259603-bh198xgl	421	12	the	the	DT
cord-259603-bh198xgl	421	13	two	two	CD
cord-259603-bh198xgl	421	14	enzymes	enzyme	NNS
cord-259603-bh198xgl	421	15	,	,	,
cord-259603-bh198xgl	421	16	it	-PRON-	PRP
cord-259603-bh198xgl	421	17	is	be	VBZ
cord-259603-bh198xgl	421	18	interesting	interesting	JJ
cord-259603-bh198xgl	421	19	to	to	TO
cord-259603-bh198xgl	421	20	have	have	VB
cord-259603-bh198xgl	421	21	a	a	DT
cord-259603-bh198xgl	421	22	closer	close	JJR
cord-259603-bh198xgl	421	23	look	look	NN
cord-259603-bh198xgl	421	24	at	at	IN
cord-259603-bh198xgl	421	25	the	the	DT
cord-259603-bh198xgl	421	26	recently	recently	RB
cord-259603-bh198xgl	421	27	published	publish	VBN
cord-259603-bh198xgl	421	28	EAV	EAV	NNP
cord-259603-bh198xgl	421	29	nsp10-helicase	nsp10-helicase	NNP
cord-259603-bh198xgl	421	30	structure	structure	NN
cord-259603-bh198xgl	421	31	(	(	-LRB-
cord-259603-bh198xgl	421	32	Deng	Deng	NNP
cord-259603-bh198xgl	421	33	et	et	FW
cord-259603-bh198xgl	421	34	al	al	NNP
cord-259603-bh198xgl	421	35	.	.	NNP
cord-259603-bh198xgl	421	36	,	,	,
cord-259603-bh198xgl	421	37	2014	2014	CD
cord-259603-bh198xgl	421	38	)	)	-RRB-
cord-259603-bh198xgl	421	39	.	.	.
cord-259603-bh198xgl	422	1	The	the	DT
cord-259603-bh198xgl	422	2	overall	overall	JJ
cord-259603-bh198xgl	422	3	structure	structure	NN
cord-259603-bh198xgl	422	4	of	of	IN
cord-259603-bh198xgl	422	5	EAV	EAV	NNP
cord-259603-bh198xgl	422	6	nsp10	nsp10	NNP
cord-259603-bh198xgl	422	7	(	(	-LRB-
cord-259603-bh198xgl	422	8	Fig	Fig	NNP
cord-259603-bh198xgl	422	9	.	.	.
cord-259603-bh198xgl	422	10	4	4	LS
cord-259603-bh198xgl	422	11	)	)	-RRB-
cord-259603-bh198xgl	422	12	consists	consist	VBZ
cord-259603-bh198xgl	422	13	of	of	IN
cord-259603-bh198xgl	422	14	the	the	DT
cord-259603-bh198xgl	422	15	N	N	NNP
cord-259603-bh198xgl	422	16	-	-	HYPH
cord-259603-bh198xgl	422	17	terminal	terminal	NN
cord-259603-bh198xgl	422	18	ZBD	ZBD	NNP
cord-259603-bh198xgl	422	19	,	,	,
cord-259603-bh198xgl	422	20	a	a	DT
cord-259603-bh198xgl	422	21	new	new	JJ
cord-259603-bh198xgl	422	22	domain	domain	NN
cord-259603-bh198xgl	422	23	designated	designate	VBN
cord-259603-bh198xgl	422	24	1B	1b	NN
cord-259603-bh198xgl	422	25	,	,	,
cord-259603-bh198xgl	422	26	the	the	DT
cord-259603-bh198xgl	422	27	two	two	CD
cord-259603-bh198xgl	422	28	recA	reca	JJ
cord-259603-bh198xgl	422	29	-	-	HYPH
cord-259603-bh198xgl	422	30	like	like	JJ
cord-259603-bh198xgl	422	31	HEL1	HEL1	NNP
cord-259603-bh198xgl	422	32	domains	domain	NNS
cord-259603-bh198xgl	422	33	(	(	-LRB-
cord-259603-bh198xgl	422	34	1A	1a	NN
cord-259603-bh198xgl	422	35	and	and	CC
cord-259603-bh198xgl	422	36	2A	2a	CD
cord-259603-bh198xgl	422	37	)	)	-RRB-
cord-259603-bh198xgl	422	38	,	,	,
cord-259603-bh198xgl	422	39	and	and	CC
cord-259603-bh198xgl	422	40	a	a	DT
cord-259603-bh198xgl	422	41	short	short	JJ
cord-259603-bh198xgl	422	42	C	c	NN
cord-259603-bh198xgl	422	43	-	-	HYPH
cord-259603-bh198xgl	422	44	terminal	terminal	NN
cord-259603-bh198xgl	422	45	domain	domain	NN
cord-259603-bh198xgl	422	46	,	,	,
cord-259603-bh198xgl	422	47	which	which	WDT
cord-259603-bh198xgl	422	48	is	be	VBZ
cord-259603-bh198xgl	422	49	not	not	RB
cord-259603-bh198xgl	422	50	conserved	conserve	VBN
cord-259603-bh198xgl	422	51	among	among	IN
cord-259603-bh198xgl	422	52	nidoviruses	nidoviruse	NNS
cord-259603-bh198xgl	422	53	and	and	CC
cord-259603-bh198xgl	422	54	needed	need	VBN
cord-259603-bh198xgl	422	55	to	to	TO
cord-259603-bh198xgl	422	56	be	be	VB
cord-259603-bh198xgl	422	57	deleted	delete	VBN
cord-259603-bh198xgl	422	58	to	to	TO
cord-259603-bh198xgl	422	59	allow	allow	VB
cord-259603-bh198xgl	422	60	nsp10	nsp10	NNP
cord-259603-bh198xgl	422	61	crystallization	crystallization	NN
cord-259603-bh198xgl	422	62	.	.	.
cord-259603-bh198xgl	423	1	This	this	DT
cord-259603-bh198xgl	423	2	65-amino	65-amino	CD
cord-259603-bh198xgl	423	3	-	-	HYPH
cord-259603-bh198xgl	423	4	acid	acid	NN
cord-259603-bh198xgl	423	5	C	c	NN
cord-259603-bh198xgl	423	6	-	-	HYPH
cord-259603-bh198xgl	423	7	terminal	terminal	NN
cord-259603-bh198xgl	423	8	truncation	truncation	NN
cord-259603-bh198xgl	423	9	did	do	VBD
cord-259603-bh198xgl	423	10	not	not	RB
cord-259603-bh198xgl	423	11	affect	affect	VB
cord-259603-bh198xgl	423	12	the	the	DT
cord-259603-bh198xgl	423	13	helicase	helicase	NN
cord-259603-bh198xgl	423	14	core	core	NN
cord-259603-bh198xgl	423	15	domains	domain	NNS
cord-259603-bh198xgl	423	16	and	and	CC
cord-259603-bh198xgl	423	17	only	only	RB
cord-259603-bh198xgl	423	18	modestly	modestly	RB
cord-259603-bh198xgl	423	19	influenced	influence	VBN
cord-259603-bh198xgl	423	20	levels	level	NNS
cord-259603-bh198xgl	423	21	of	of	IN
cord-259603-bh198xgl	423	22	ATPase	ATPase	NNP
cord-259603-bh198xgl	423	23	and	and	CC
cord-259603-bh198xgl	423	24	helicase	helicase	NN
cord-259603-bh198xgl	423	25	activity	activity	NN
cord-259603-bh198xgl	423	26	compared	compare	VBN
cord-259603-bh198xgl	423	27	to	to	IN
cord-259603-bh198xgl	423	28	the	the	DT
cord-259603-bh198xgl	423	29	full	full	JJ
cord-259603-bh198xgl	423	30	-	-	HYPH
cord-259603-bh198xgl	423	31	length	length	NN
cord-259603-bh198xgl	423	32	protein	protein	NN
cord-259603-bh198xgl	423	33	(	(	-LRB-
cord-259603-bh198xgl	423	34	Deng	Deng	NNP
cord-259603-bh198xgl	423	35	et	et	FW
cord-259603-bh198xgl	423	36	al	al	NNP
cord-259603-bh198xgl	423	37	.	.	NNP
cord-259603-bh198xgl	423	38	,	,	,
cord-259603-bh198xgl	423	39	2014	2014	CD
cord-259603-bh198xgl	423	40	)	)	-RRB-
cord-259603-bh198xgl	423	41	.	.	.
cord-259603-bh198xgl	424	1	Compared	compare	VBN
cord-259603-bh198xgl	424	2	to	to	IN
cord-259603-bh198xgl	424	3	cellular	cellular	JJ
cord-259603-bh198xgl	424	4	representatives	representative	NNS
cord-259603-bh198xgl	424	5	of	of	IN
cord-259603-bh198xgl	424	6	the	the	DT
cord-259603-bh198xgl	424	7	SF1	SF1	NNP
cord-259603-bh198xgl	424	8	helicase	helicase	NNP
cord-259603-bh198xgl	424	9	superfamily	superfamily	NN
cord-259603-bh198xgl	424	10	,	,	,
cord-259603-bh198xgl	424	11	nsp10	nsp10	NNPS
cord-259603-bh198xgl	424	12	is	be	VBZ
cord-259603-bh198xgl	424	13	most	most	RBS
cord-259603-bh198xgl	424	14	similar	similar	JJ
cord-259603-bh198xgl	424	15	to	to	IN
cord-259603-bh198xgl	424	16	Upf1	Upf1	NNP
cord-259603-bh198xgl	424	17	and	and	CC
cord-259603-bh198xgl	424	18	its	-PRON-	PRP$
cord-259603-bh198xgl	424	19	close	close	JJ
cord-259603-bh198xgl	424	20	homolog	homolog	NN
cord-259603-bh198xgl	424	21	Ighmbp2	Ighmbp2	NNP
cord-259603-bh198xgl	424	22	,	,	,
cord-259603-bh198xgl	424	23	which	which	WDT
cord-259603-bh198xgl	424	24	also	also	RB
cord-259603-bh198xgl	424	25	contain	contain	VBP
cord-259603-bh198xgl	424	26	an	an	DT
cord-259603-bh198xgl	424	27	N	n	CD
cord-259603-bh198xgl	424	28	-	-	HYPH
cord-259603-bh198xgl	424	29	terminal	terminal	NN
cord-259603-bh198xgl	424	30	ZBD	ZBD	NNP
cord-259603-bh198xgl	424	31	.	.	.
cord-259603-bh198xgl	425	1	Moreover	moreover	RB
cord-259603-bh198xgl	425	2	,	,	,
cord-259603-bh198xgl	425	3	the	the	DT
cord-259603-bh198xgl	425	4	location	location	NN
cord-259603-bh198xgl	425	5	and	and	CC
cord-259603-bh198xgl	425	6	orientation	orientation	NN
cord-259603-bh198xgl	425	7	of	of	IN
cord-259603-bh198xgl	425	8	the	the	DT
cord-259603-bh198xgl	425	9	newly	newly	RB
cord-259603-bh198xgl	425	10	discovered	discover	VBN
cord-259603-bh198xgl	425	11	1B	1b	CD
cord-259603-bh198xgl	425	12	domain	domain	NN
cord-259603-bh198xgl	425	13	of	of	IN
cord-259603-bh198xgl	425	14	nsp10	nsp10	NNPS
cord-259603-bh198xgl	425	15	(	(	-LRB-
cord-259603-bh198xgl	425	16	residues	residue	NNS
cord-259603-bh198xgl	425	17	83	83	CD
cord-259603-bh198xgl	425	18	-	-	SYM
cord-259603-bh198xgl	425	19	137	137	CD
cord-259603-bh198xgl	425	20	)	)	-RRB-
cord-259603-bh198xgl	425	21	resembles	resemble	VBZ
cord-259603-bh198xgl	425	22	that	that	DT
cord-259603-bh198xgl	425	23	of	of	IN
cord-259603-bh198xgl	425	24	the	the	DT
cord-259603-bh198xgl	425	25	domain	domain	NN
cord-259603-bh198xgl	425	26	with	with	IN
cord-259603-bh198xgl	425	27	the	the	DT
cord-259603-bh198xgl	425	28	same	same	JJ
cord-259603-bh198xgl	425	29	name	name	NN
cord-259603-bh198xgl	425	30	found	find	VBN
cord-259603-bh198xgl	425	31	in	in	IN
cord-259603-bh198xgl	425	32	the	the	DT
cord-259603-bh198xgl	425	33	Upf1-like	upf1-like	JJ
cord-259603-bh198xgl	425	34	helicase	helicase	NN
cord-259603-bh198xgl	425	35	subfamily	subfamily	NN
cord-259603-bh198xgl	425	36	.	.	.
cord-259603-bh198xgl	426	1	The	the	DT
cord-259603-bh198xgl	426	2	nsp10	nsp10	JJ
cord-259603-bh198xgl	426	3	ZBD	ZBD	NNP
cord-259603-bh198xgl	426	4	uses	use	VBZ
cord-259603-bh198xgl	426	5	12	12	CD
cord-259603-bh198xgl	426	6	conserved	conserve	VBN
cord-259603-bh198xgl	426	7	Cys	Cys	NNP
cord-259603-bh198xgl	426	8	and	and	CC
cord-259603-bh198xgl	426	9	His	-PRON-	PRP$
cord-259603-bh198xgl	426	10	residues	residue	NNS
cord-259603-bh198xgl	426	11	to	to	TO
cord-259603-bh198xgl	426	12	coordinate	coordinate	VB
cord-259603-bh198xgl	426	13	three	three	CD
cord-259603-bh198xgl	426	14	zinc	zinc	NN
cord-259603-bh198xgl	426	15	ions	ion	NNS
cord-259603-bh198xgl	426	16	and	and	CC
cord-259603-bh198xgl	426	17	folds	fold	VBZ
cord-259603-bh198xgl	426	18	into	into	IN
cord-259603-bh198xgl	426	19	two	two	CD
cord-259603-bh198xgl	426	20	zinc	zinc	NN
cord-259603-bh198xgl	426	21	-	-	HYPH
cord-259603-bh198xgl	426	22	binding	bind	VBG
cord-259603-bh198xgl	426	23	modules	module	NNS
cord-259603-bh198xgl	426	24	that	that	WDT
cord-259603-bh198xgl	426	25	are	be	VBP
cord-259603-bh198xgl	426	26	connected	connect	VBN
cord-259603-bh198xgl	426	27	by	by	IN
cord-259603-bh198xgl	426	28	a	a	DT
cord-259603-bh198xgl	426	29	disordered	disordered	JJ
cord-259603-bh198xgl	426	30	region	region	NN
cord-259603-bh198xgl	426	31	.	.	.
cord-259603-bh198xgl	427	1	The	the	DT
cord-259603-bh198xgl	427	2	N	n	CD
cord-259603-bh198xgl	427	3	-	-	HYPH
cord-259603-bh198xgl	427	4	terminal	terminal	NN
cord-259603-bh198xgl	427	5	RING	ring	NN
cord-259603-bh198xgl	427	6	-	-	HYPH
cord-259603-bh198xgl	427	7	like	like	JJ
cord-259603-bh198xgl	427	8	structure	structure	NN
cord-259603-bh198xgl	427	9	of	of	IN
cord-259603-bh198xgl	427	10	nsp10	nsp10	NNP
cord-259603-bh198xgl	427	11	coordinates	coordinate	VBZ
cord-259603-bh198xgl	427	12	two	two	CD
cord-259603-bh198xgl	427	13	zinc	zinc	NN
cord-259603-bh198xgl	427	14	ions	ion	NNS
cord-259603-bh198xgl	427	15	and	and	CC
cord-259603-bh198xgl	427	16	the	the	DT
cord-259603-bh198xgl	427	17	closest	close	JJS
cord-259603-bh198xgl	427	18	similarity	similarity	NN
cord-259603-bh198xgl	427	19	that	that	WDT
cord-259603-bh198xgl	427	20	was	be	VBD
cord-259603-bh198xgl	427	21	found	find	VBN
cord-259603-bh198xgl	427	22	for	for	IN
cord-259603-bh198xgl	427	23	this	this	DT
cord-259603-bh198xgl	427	24	module	module	NN
cord-259603-bh198xgl	427	25	was	be	VBD
cord-259603-bh198xgl	427	26	with	with	IN
cord-259603-bh198xgl	427	27	the	the	DT
cord-259603-bh198xgl	427	28	N	n	CD
cord-259603-bh198xgl	427	29	-	-	HYPH
cord-259603-bh198xgl	427	30	terminal	terminal	NN
cord-259603-bh198xgl	427	31	zinc	zinc	NN
cord-259603-bh198xgl	427	32	-	-	HYPH
cord-259603-bh198xgl	427	33	binding	bind	VBG
cord-259603-bh198xgl	427	34	CH	ch	NN
cord-259603-bh198xgl	427	35	-	-	HYPH
cord-259603-bh198xgl	427	36	domain	domain	NN
cord-259603-bh198xgl	427	37	of	of	IN
cord-259603-bh198xgl	427	38	Upf1	Upf1	NNP
cord-259603-bh198xgl	427	39	.	.	.
cord-259603-bh198xgl	428	1	Both	both	DT
cord-259603-bh198xgl	428	2	proteins	protein	NNS
cord-259603-bh198xgl	428	3	have	have	VBP
cord-259603-bh198xgl	428	4	a	a	DT
cord-259603-bh198xgl	428	5	second	second	JJ
cord-259603-bh198xgl	428	6	zinc	zinc	NN
cord-259603-bh198xgl	428	7	-	-	HYPH
cord-259603-bh198xgl	428	8	binding	bind	VBG
cord-259603-bh198xgl	428	9	module	module	NN
cord-259603-bh198xgl	428	10	downstream	downstream	RB
cord-259603-bh198xgl	428	11	(	(	-LRB-
cord-259603-bh198xgl	428	12	a	a	DT
cord-259603-bh198xgl	428	13	so	so	RB
cord-259603-bh198xgl	428	14	-	-	HYPH
cord-259603-bh198xgl	428	15	called	call	VBN
cord-259603-bh198xgl	428	16	treble	treble	JJ
cord-259603-bh198xgl	428	17	-	-	HYPH
cord-259603-bh198xgl	428	18	clef	clef	NN
cord-259603-bh198xgl	428	19	zinc	zinc	NN
cord-259603-bh198xgl	428	20	finger	finger	NN
cord-259603-bh198xgl	428	21	in	in	IN
cord-259603-bh198xgl	428	22	the	the	DT
cord-259603-bh198xgl	428	23	case	case	NN
cord-259603-bh198xgl	428	24	of	of	IN
cord-259603-bh198xgl	428	25	nsp10	nsp10	NNP
cord-259603-bh198xgl	428	26	)	)	-RRB-
cord-259603-bh198xgl	428	27	,	,	,
cord-259603-bh198xgl	428	28	but	but	CC
cord-259603-bh198xgl	428	29	these	these	DT
cord-259603-bh198xgl	428	30	are	be	VBP
cord-259603-bh198xgl	428	31	structurally	structurally	RB
cord-259603-bh198xgl	428	32	different	different	JJ
cord-259603-bh198xgl	428	33	,	,	,
cord-259603-bh198xgl	428	34	suggesting	suggest	VBG
cord-259603-bh198xgl	428	35	that	that	IN
cord-259603-bh198xgl	428	36	the	the	DT
cord-259603-bh198xgl	428	37	nidoviral	nidoviral	JJ
cord-259603-bh198xgl	428	38	ZBD	ZBD	NNP
cord-259603-bh198xgl	428	39	represents	represent	VBZ
cord-259603-bh198xgl	428	40	a	a	DT
cord-259603-bh198xgl	428	41	new	new	JJ
cord-259603-bh198xgl	428	42	kind	kind	NN
cord-259603-bh198xgl	428	43	of	of	IN
cord-259603-bh198xgl	428	44	complex	complex	JJ
cord-259603-bh198xgl	428	45	zinc	zinc	NN
cord-259603-bh198xgl	428	46	-	-	HYPH
cord-259603-bh198xgl	428	47	binding	bind	VBG
cord-259603-bh198xgl	428	48	element	element	NN
cord-259603-bh198xgl	428	49	.	.	.
cord-259603-bh198xgl	429	1	The	the	DT
cord-259603-bh198xgl	429	2	previous	previous	JJ
cord-259603-bh198xgl	429	3	suggestion	suggestion	NN
cord-259603-bh198xgl	429	4	of	of	IN
cord-259603-bh198xgl	429	5	ZBD	ZBD	NNP
cord-259603-bh198xgl	429	6	codetermining	codetermine	VBG
cord-259603-bh198xgl	429	7	HEL1	HEL1	NNP
cord-259603-bh198xgl	429	8	function	function	NN
cord-259603-bh198xgl	429	9	was	be	VBD
cord-259603-bh198xgl	429	10	strengthened	strengthen	VBN
cord-259603-bh198xgl	429	11	by	by	IN
cord-259603-bh198xgl	429	12	the	the	DT
cord-259603-bh198xgl	429	13	presence	presence	NN
cord-259603-bh198xgl	429	14	of	of	IN
cord-259603-bh198xgl	429	15	an	an	DT
cord-259603-bh198xgl	429	16	extensive	extensive	JJ
cord-259603-bh198xgl	429	17	interface	interface	NN
cord-259603-bh198xgl	429	18	of	of	IN
cord-259603-bh198xgl	429	19	1019	1019	CD
cord-259603-bh198xgl	429	20	Å	å	NN
cord-259603-bh198xgl	429	21	2	2	CD
cord-259603-bh198xgl	429	22	that	that	WDT
cord-259603-bh198xgl	429	23	was	be	VBD
cord-259603-bh198xgl	429	24	proposed	propose	VBN
cord-259603-bh198xgl	429	25	to	to	TO
cord-259603-bh198xgl	429	26	be	be	VB
cord-259603-bh198xgl	429	27	involved	involve	VBN
cord-259603-bh198xgl	429	28	in	in	IN
cord-259603-bh198xgl	429	29	intramolecular	intramolecular	JJ
cord-259603-bh198xgl	429	30	signaling	signaling	NN
cord-259603-bh198xgl	429	31	(	(	-LRB-
cord-259603-bh198xgl	429	32	Deng	Deng	NNP
cord-259603-bh198xgl	429	33	et	et	FW
cord-259603-bh198xgl	429	34	al	al	NNP
cord-259603-bh198xgl	429	35	.	.	NNP
cord-259603-bh198xgl	429	36	,	,	,
cord-259603-bh198xgl	429	37	2014	2014	CD
cord-259603-bh198xgl	429	38	)	)	-RRB-
cord-259603-bh198xgl	429	39	.	.	.
cord-259603-bh198xgl	430	1	A	a	DT
cord-259603-bh198xgl	430	2	second	second	JJ
cord-259603-bh198xgl	430	3	crystal	crystal	NN
cord-259603-bh198xgl	430	4	structure	structure	NN
cord-259603-bh198xgl	430	5	was	be	VBD
cord-259603-bh198xgl	430	6	obtained	obtain	VBN
cord-259603-bh198xgl	430	7	for	for	IN
cord-259603-bh198xgl	430	8	nsp10	nsp10	NNPS
cord-259603-bh198xgl	430	9	in	in	IN
cord-259603-bh198xgl	430	10	complex	complex	NN
cord-259603-bh198xgl	430	11	with	with	IN
cord-259603-bh198xgl	430	12	a	a	DT
cord-259603-bh198xgl	430	13	partially	partially	RB
cord-259603-bh198xgl	430	14	double	double	RB
cord-259603-bh198xgl	430	15	-	-	HYPH
cord-259603-bh198xgl	430	16	stranded	strand	VBN
cord-259603-bh198xgl	430	17	DNA	dna	NN
cord-259603-bh198xgl	430	18	substrate	substrate	NN
cord-259603-bh198xgl	430	19	,	,	,
cord-259603-bh198xgl	430	20	revealing	reveal	VBG
cord-259603-bh198xgl	430	21	possible	possible	JJ
cord-259603-bh198xgl	430	22	nucleic	nucleic	JJ
cord-259603-bh198xgl	430	23	acid	acid	NN
cord-259603-bh198xgl	430	24	-	-	HYPH
cord-259603-bh198xgl	430	25	binding	bind	VBG
cord-259603-bh198xgl	430	26	clefts	cleft	NNS
cord-259603-bh198xgl	430	27	at	at	IN
cord-259603-bh198xgl	430	28	the	the	DT
cord-259603-bh198xgl	430	29	protein	protein	NN
cord-259603-bh198xgl	430	30	's	's	POS
cord-259603-bh198xgl	430	31	surface	surface	NN
cord-259603-bh198xgl	430	32	that	that	WDT
cord-259603-bh198xgl	430	33	are	be	VBP
cord-259603-bh198xgl	430	34	formed	form	VBN
cord-259603-bh198xgl	430	35	by	by	IN
cord-259603-bh198xgl	430	36	the	the	DT
cord-259603-bh198xgl	430	37	ZBD	ZBD	NNP
cord-259603-bh198xgl	430	38	+	+	SYM
cord-259603-bh198xgl	430	39	1B	1b	NN
cord-259603-bh198xgl	430	40	and	and	CC
cord-259603-bh198xgl	430	41	ZBD	ZBD	NNP
cord-259603-bh198xgl	430	42	+	+	CC
cord-259603-bh198xgl	430	43	1A	1a	NN
cord-259603-bh198xgl	430	44	domains	domain	NNS
cord-259603-bh198xgl	430	45	.	.	.
cord-259603-bh198xgl	431	1	Although	although	IN
cord-259603-bh198xgl	431	2	the	the	DT
cord-259603-bh198xgl	431	3	exact	exact	JJ
cord-259603-bh198xgl	431	4	path	path	NN
cord-259603-bh198xgl	431	5	of	of	IN
cord-259603-bh198xgl	431	6	the	the	DT
cord-259603-bh198xgl	431	7	nucleic	nucleic	JJ
cord-259603-bh198xgl	431	8	acid	acid	NN
cord-259603-bh198xgl	431	9	strands	strand	NNS
cord-259603-bh198xgl	431	10	could	could	MD
cord-259603-bh198xgl	431	11	not	not	RB
cord-259603-bh198xgl	431	12	yet	yet	RB
cord-259603-bh198xgl	431	13	be	be	VB
cord-259603-bh198xgl	431	14	determined	determine	VBN
cord-259603-bh198xgl	431	15	,	,	,
cord-259603-bh198xgl	431	16	it	-PRON-	PRP
cord-259603-bh198xgl	431	17	became	become	VBD
cord-259603-bh198xgl	431	18	clear	clear	JJ
cord-259603-bh198xgl	431	19	that	that	IN
cord-259603-bh198xgl	431	20	the	the	DT
cord-259603-bh198xgl	431	21	positively	positively	RB
cord-259603-bh198xgl	431	22	charged	charge	VBN
cord-259603-bh198xgl	431	23	ZBD	ZBD	NNP
cord-259603-bh198xgl	431	24	,	,	,
cord-259603-bh198xgl	431	25	and	and	CC
cord-259603-bh198xgl	431	26	in	in	IN
cord-259603-bh198xgl	431	27	particular	particular	JJ
cord-259603-bh198xgl	431	28	its	-PRON-	PRP$
cord-259603-bh198xgl	431	29	N	n	CD
cord-259603-bh198xgl	431	30	-	-	HYPH
cord-259603-bh198xgl	431	31	terminal	terminal	NN
cord-259603-bh198xgl	431	32	RING	ring	NN
cord-259603-bh198xgl	431	33	-	-	HYPH
cord-259603-bh198xgl	431	34	like	like	JJ
cord-259603-bh198xgl	431	35	module	module	NN
cord-259603-bh198xgl	431	36	,	,	,
cord-259603-bh198xgl	431	37	must	must	MD
cord-259603-bh198xgl	431	38	be	be	VB
cord-259603-bh198xgl	431	39	involved	involve	VBN
cord-259603-bh198xgl	431	40	in	in	IN
cord-259603-bh198xgl	431	41	nucleic	nucleic	JJ
cord-259603-bh198xgl	431	42	acid	acid	NN
cord-259603-bh198xgl	431	43	binding	binding	NN
cord-259603-bh198xgl	431	44	.	.	.
cord-259603-bh198xgl	432	1	In	in	IN
cord-259603-bh198xgl	432	2	line	line	NN
cord-259603-bh198xgl	432	3	with	with	IN
cord-259603-bh198xgl	432	4	the	the	DT
cord-259603-bh198xgl	432	5	biochemical	biochemical	JJ
cord-259603-bh198xgl	432	6	data	datum	NNS
cord-259603-bh198xgl	432	7	summarized	summarize	VBD
cord-259603-bh198xgl	432	8	earlier	early	RBR
cord-259603-bh198xgl	432	9	,	,	,
cord-259603-bh198xgl	432	10	most	most	JJS
cord-259603-bh198xgl	432	11	of	of	IN
cord-259603-bh198xgl	432	12	the	the	DT
cord-259603-bh198xgl	432	13	nsp10-substrate	nsp10-substrate	JJ
cord-259603-bh198xgl	432	14	contacts	contact	NNS
cord-259603-bh198xgl	432	15	identified	identify	VBN
cord-259603-bh198xgl	432	16	are	be	VBP
cord-259603-bh198xgl	432	17	not	not	RB
cord-259603-bh198xgl	432	18	base	base	NN
cord-259603-bh198xgl	432	19	-	-	HYPH
cord-259603-bh198xgl	432	20	specific	specific	JJ
cord-259603-bh198xgl	432	21	and	and	CC
cord-259603-bh198xgl	432	22	occur	occur	VBP
cord-259603-bh198xgl	432	23	with	with	IN
cord-259603-bh198xgl	432	24	the	the	DT
cord-259603-bh198xgl	432	25	nucleic	nucleic	JJ
cord-259603-bh198xgl	432	26	acid	acid	NN
cord-259603-bh198xgl	432	27	backbone	backbone	NN
cord-259603-bh198xgl	432	28	.	.	.
cord-259603-bh198xgl	433	1	Whereas	whereas	IN
cord-259603-bh198xgl	433	2	the	the	DT
cord-259603-bh198xgl	433	3	HEL1	HEL1	NNP
cord-259603-bh198xgl	433	4	core	core	NN
cord-259603-bh198xgl	433	5	domains	domain	NNS
cord-259603-bh198xgl	433	6	were	be	VBD
cord-259603-bh198xgl	433	7	found	find	VBN
cord-259603-bh198xgl	433	8	to	to	TO
cord-259603-bh198xgl	433	9	be	be	VB
cord-259603-bh198xgl	433	10	quite	quite	RB
cord-259603-bh198xgl	433	11	similar	similar	JJ
cord-259603-bh198xgl	433	12	in	in	IN
cord-259603-bh198xgl	433	13	the	the	DT
cord-259603-bh198xgl	433	14	absence	absence	NN
cord-259603-bh198xgl	433	15	or	or	CC
cord-259603-bh198xgl	433	16	presence	presence	NN
cord-259603-bh198xgl	433	17	of	of	IN
cord-259603-bh198xgl	433	18	bound	bind	VBN
cord-259603-bh198xgl	433	19	substrate	substrate	NN
cord-259603-bh198xgl	433	20	,	,	,
cord-259603-bh198xgl	433	21	a	a	DT
cord-259603-bh198xgl	433	22	remarkable	remarkable	JJ
cord-259603-bh198xgl	433	23	29	29	CD
cord-259603-bh198xgl	433	24	degree	degree	NN
cord-259603-bh198xgl	433	25	rotation	rotation	NN
cord-259603-bh198xgl	433	26	was	be	VBD
cord-259603-bh198xgl	433	27	observed	observe	VBN
cord-259603-bh198xgl	433	28	for	for	IN
cord-259603-bh198xgl	433	29	domain	domain	NN
cord-259603-bh198xgl	433	30	1B	1b	CD
cord-259603-bh198xgl	433	31	,	,	,
cord-259603-bh198xgl	433	32	enlarging	enlarge	VBG
cord-259603-bh198xgl	433	33	the	the	DT
cord-259603-bh198xgl	433	34	dimensions	dimension	NNS
cord-259603-bh198xgl	433	35	of	of	IN
cord-259603-bh198xgl	433	36	the	the	DT
cord-259603-bh198xgl	433	37	nucleic	nucleic	JJ
cord-259603-bh198xgl	433	38	acid	acid	NN
cord-259603-bh198xgl	433	39	substrate	substrate	NN
cord-259603-bh198xgl	433	40	channel	channel	NN
cord-259603-bh198xgl	433	41	formed	form	VBN
cord-259603-bh198xgl	433	42	by	by	IN
cord-259603-bh198xgl	433	43	domains	domain	NNS
cord-259603-bh198xgl	433	44	1A	1a	CD
cord-259603-bh198xgl	433	45	and	and	CC
cord-259603-bh198xgl	433	46	1B	1b	CD
cord-259603-bh198xgl	433	47	,	,	,
cord-259603-bh198xgl	433	48	but	but	CC
cord-259603-bh198xgl	433	49	not	not	RB
cord-259603-bh198xgl	433	50	allowing	allow	VBG
cord-259603-bh198xgl	433	51	it	-PRON-	PRP
cord-259603-bh198xgl	433	52	to	to	TO
cord-259603-bh198xgl	433	53	accommodate	accommodate	VB
cord-259603-bh198xgl	433	54	a	a	DT
cord-259603-bh198xgl	433	55	duplex	duplex	NN
cord-259603-bh198xgl	433	56	substrate	substrate	NN
cord-259603-bh198xgl	433	57	.	.	.
cord-259603-bh198xgl	434	1	Consequently	consequently	RB
cord-259603-bh198xgl	434	2	,	,	,
cord-259603-bh198xgl	434	3	it	-PRON-	PRP
cord-259603-bh198xgl	434	4	was	be	VBD
cord-259603-bh198xgl	434	5	postulated	postulate	VBN
cord-259603-bh198xgl	434	6	that	that	IN
cord-259603-bh198xgl	434	7	an	an	DT
cord-259603-bh198xgl	434	8	element	element	NN
cord-259603-bh198xgl	434	9	near	near	IN
cord-259603-bh198xgl	434	10	the	the	DT
cord-259603-bh198xgl	434	11	entrance	entrance	NN
cord-259603-bh198xgl	434	12	of	of	IN
cord-259603-bh198xgl	434	13	the	the	DT
cord-259603-bh198xgl	434	14	substrate	substrate	JJ
cord-259603-bh198xgl	434	15	channel	channel	NN
cord-259603-bh198xgl	434	16	may	may	MD
cord-259603-bh198xgl	434	17	destabilize	destabilize	VB
cord-259603-bh198xgl	434	18	the	the	DT
cord-259603-bh198xgl	434	19	duplex	duplex	NN
cord-259603-bh198xgl	434	20	and	and	CC
cord-259603-bh198xgl	434	21	facilitate	facilitate	VB
cord-259603-bh198xgl	434	22	the	the	DT
cord-259603-bh198xgl	434	23	entrance	entrance	NN
cord-259603-bh198xgl	434	24	of	of	IN
cord-259603-bh198xgl	434	25	one	one	CD
cord-259603-bh198xgl	434	26	of	of	IN
cord-259603-bh198xgl	434	27	the	the	DT
cord-259603-bh198xgl	434	28	strands	strand	NNS
cord-259603-bh198xgl	434	29	into	into	IN
cord-259603-bh198xgl	434	30	the	the	DT
cord-259603-bh198xgl	434	31	channel	channel	NN
cord-259603-bh198xgl	434	32	.	.	.
cord-259603-bh198xgl	435	1	Since	since	IN
cord-259603-bh198xgl	435	2	the	the	DT
cord-259603-bh198xgl	435	3	double	double	RB
cord-259603-bh198xgl	435	4	-	-	HYPH
cord-259603-bh198xgl	435	5	stranded	strand	VBN
cord-259603-bh198xgl	435	6	region	region	NN
cord-259603-bh198xgl	435	7	of	of	IN
cord-259603-bh198xgl	435	8	the	the	DT
cord-259603-bh198xgl	435	9	duplex	duplex	NN
cord-259603-bh198xgl	435	10	could	could	MD
cord-259603-bh198xgl	435	11	not	not	RB
cord-259603-bh198xgl	435	12	be	be	VB
cord-259603-bh198xgl	435	13	modeled	model	VBN
cord-259603-bh198xgl	435	14	,	,	,
cord-259603-bh198xgl	435	15	additional	additional	JJ
cord-259603-bh198xgl	435	16	studies	study	NNS
cord-259603-bh198xgl	435	17	are	be	VBP
cord-259603-bh198xgl	435	18	needed	need	VBN
cord-259603-bh198xgl	435	19	to	to	TO
cord-259603-bh198xgl	435	20	verify	verify	VB
cord-259603-bh198xgl	435	21	the	the	DT
cord-259603-bh198xgl	435	22	existence	existence	NN
cord-259603-bh198xgl	435	23	and	and	CC
cord-259603-bh198xgl	435	24	molecular	molecular	JJ
cord-259603-bh198xgl	435	25	details	detail	NNS
cord-259603-bh198xgl	435	26	of	of	IN
cord-259603-bh198xgl	435	27	this	this	DT
cord-259603-bh198xgl	435	28	proposed	propose	VBN
cord-259603-bh198xgl	435	29	unwinding	unwinding	NN
cord-259603-bh198xgl	435	30	mechanism	mechanism	NN
cord-259603-bh198xgl	435	31	(	(	-LRB-
cord-259603-bh198xgl	435	32	Deng	Deng	NNP
cord-259603-bh198xgl	435	33	et	et	FW
cord-259603-bh198xgl	435	34	al	al	NNP
cord-259603-bh198xgl	435	35	.	.	NNP
cord-259603-bh198xgl	435	36	,	,	,
cord-259603-bh198xgl	435	37	2014	2014	CD
cord-259603-bh198xgl	435	38	;	;	:
cord-259603-bh198xgl	435	39	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	435	40	et	et	NNP
cord-259603-bh198xgl	435	41	al	al	NNP
cord-259603-bh198xgl	435	42	.	.	NNP
cord-259603-bh198xgl	435	43	,	,	,
cord-259603-bh198xgl	435	44	2015c	2015c	CD
cord-259603-bh198xgl	435	45	)	)	-RRB-
cord-259603-bh198xgl	435	46	.	.	.
cord-259603-bh198xgl	436	1	Likewise	likewise	RB
cord-259603-bh198xgl	436	2	,	,	,
cord-259603-bh198xgl	436	3	direct	direct	JJ
cord-259603-bh198xgl	436	4	structural	structural	JJ
cord-259603-bh198xgl	436	5	information	information	NN
cord-259603-bh198xgl	436	6	on	on	IN
cord-259603-bh198xgl	436	7	CoV	CoV	NNP
cord-259603-bh198xgl	436	8	nsp13	nsp13	NNP
cord-259603-bh198xgl	436	9	is	be	VBZ
cord-259603-bh198xgl	436	10	needed	need	VBN
cord-259603-bh198xgl	436	11	to	to	TO
cord-259603-bh198xgl	436	12	be	be	VB
cord-259603-bh198xgl	436	13	able	able	JJ
cord-259603-bh198xgl	436	14	to	to	TO
cord-259603-bh198xgl	436	15	assess	assess	VB
cord-259603-bh198xgl	436	16	to	to	TO
cord-259603-bh198xgl	436	17	which	which	WDT
cord-259603-bh198xgl	436	18	extent	extent	NN
cord-259603-bh198xgl	436	19	the	the	DT
cord-259603-bh198xgl	436	20	structural	structural	JJ
cord-259603-bh198xgl	436	21	observations	observation	NNS
cord-259603-bh198xgl	436	22	made	make	VBN
cord-259603-bh198xgl	436	23	for	for	IN
cord-259603-bh198xgl	436	24	arterivirus	arterivirus	NNP
cord-259603-bh198xgl	436	25	nsp10	nsp10	NNPS
cord-259603-bh198xgl	436	26	can	can	MD
cord-259603-bh198xgl	436	27	be	be	VB
cord-259603-bh198xgl	436	28	translated	translate	VBN
cord-259603-bh198xgl	436	29	to	to	IN
cord-259603-bh198xgl	436	30	distantly	distantly	RB
cord-259603-bh198xgl	436	31	related	relate	VBN
cord-259603-bh198xgl	436	32	(	(	-LRB-
cord-259603-bh198xgl	436	33	and	and	CC
cord-259603-bh198xgl	436	34	larger	large	JJR
cord-259603-bh198xgl	436	35	)	)	-RRB-
cord-259603-bh198xgl	436	36	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	436	37	helicases	helicase	NNS
cord-259603-bh198xgl	436	38	(	(	-LRB-
cord-259603-bh198xgl	436	39	Fig	Fig	NNP
cord-259603-bh198xgl	436	40	.	.	NNP
cord-259603-bh198xgl	436	41	4	4	CD
cord-259603-bh198xgl	436	42	)	)	-RRB-
cord-259603-bh198xgl	436	43	.	.	.
cord-259603-bh198xgl	437	1	In	in	IN
cord-259603-bh198xgl	437	2	general	general	JJ
cord-259603-bh198xgl	437	3	,	,	,
cord-259603-bh198xgl	437	4	however	however	RB
cord-259603-bh198xgl	437	5	,	,	,
cord-259603-bh198xgl	437	6	the	the	DT
cord-259603-bh198xgl	437	7	analysis	analysis	NN
cord-259603-bh198xgl	437	8	of	of	IN
cord-259603-bh198xgl	437	9	nsp10	nsp10	NNPS
cord-259603-bh198xgl	437	10	provided	provide	VBD
cord-259603-bh198xgl	437	11	a	a	DT
cord-259603-bh198xgl	437	12	clear	clear	JJ
cord-259603-bh198xgl	437	13	basis	basis	NN
cord-259603-bh198xgl	437	14	for	for	IN
cord-259603-bh198xgl	437	15	a	a	DT
cord-259603-bh198xgl	437	16	model	model	NN
cord-259603-bh198xgl	437	17	in	in	IN
cord-259603-bh198xgl	437	18	which	which	WDT
cord-259603-bh198xgl	437	19	the	the	DT
cord-259603-bh198xgl	437	20	function	function	NN
cord-259603-bh198xgl	437	21	of	of	IN
cord-259603-bh198xgl	437	22	the	the	DT
cord-259603-bh198xgl	437	23	common	common	JJ
cord-259603-bh198xgl	437	24	RecA	RecA	NNP
cord-259603-bh198xgl	437	25	-	-	HYPH
cord-259603-bh198xgl	437	26	like	like	JJ
cord-259603-bh198xgl	437	27	core	core	NN
cord-259603-bh198xgl	437	28	domains	domain	NNS
cord-259603-bh198xgl	437	29	of	of	IN
cord-259603-bh198xgl	437	30	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	437	31	helicases	helicases	NNPS
cord-259603-bh198xgl	437	32	is	be	VBZ
cord-259603-bh198xgl	437	33	modulated	modulate	VBN
cord-259603-bh198xgl	437	34	by	by	IN
cord-259603-bh198xgl	437	35	specific	specific	JJ
cord-259603-bh198xgl	437	36	extension	extension	NN
cord-259603-bh198xgl	437	37	domains	domain	NNS
cord-259603-bh198xgl	437	38	,	,	,
cord-259603-bh198xgl	437	39	presumably	presumably	RB
cord-259603-bh198xgl	437	40	to	to	TO
cord-259603-bh198xgl	437	41	facilitate	facilitate	VB
cord-259603-bh198xgl	437	42	the	the	DT
cord-259603-bh198xgl	437	43	involvement	involvement	NN
cord-259603-bh198xgl	437	44	of	of	IN
cord-259603-bh198xgl	437	45	the	the	DT
cord-259603-bh198xgl	437	46	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	437	47	helicase	helicase	NNP
cord-259603-bh198xgl	437	48	in	in	IN
cord-259603-bh198xgl	437	49	multiple	multiple	JJ
cord-259603-bh198xgl	437	50	processes	process	NNS
cord-259603-bh198xgl	437	51	in	in	IN
cord-259603-bh198xgl	437	52	the	the	DT
cord-259603-bh198xgl	437	53	infected	infected	JJ
cord-259603-bh198xgl	437	54	cell	cell	NN
cord-259603-bh198xgl	437	55	(	(	-LRB-
cord-259603-bh198xgl	437	56	see	see	VB
cord-259603-bh198xgl	437	57	later	later	RB
cord-259603-bh198xgl	437	58	)	)	-RRB-
cord-259603-bh198xgl	437	59	.	.	.
cord-259603-bh198xgl	438	1	As	as	IN
cord-259603-bh198xgl	438	2	outlined	outline	VBN
cord-259603-bh198xgl	438	3	earlier	early	RBR
cord-259603-bh198xgl	438	4	,	,	,
cord-259603-bh198xgl	438	5	the	the	DT
cord-259603-bh198xgl	438	6	biochemical	biochemical	JJ
cord-259603-bh198xgl	438	7	characterization	characterization	NN
cord-259603-bh198xgl	438	8	of	of	IN
cord-259603-bh198xgl	438	9	purified	purify	VBN
cord-259603-bh198xgl	438	10	recombinant	recombinant	JJ
cord-259603-bh198xgl	438	11	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	438	12	helicases	helicase	NNS
cord-259603-bh198xgl	438	13	,	,	,
cord-259603-bh198xgl	438	14	the	the	DT
cord-259603-bh198xgl	438	15	functional	functional	JJ
cord-259603-bh198xgl	438	16	probing	probing	NN
cord-259603-bh198xgl	438	17	of	of	IN
cord-259603-bh198xgl	438	18	(	(	-LRB-
cord-259603-bh198xgl	438	19	in	in	IN
cord-259603-bh198xgl	438	20	particular	particular	JJ
cord-259603-bh198xgl	438	21	)	)	-RRB-
cord-259603-bh198xgl	438	22	the	the	DT
cord-259603-bh198xgl	438	23	EAV	EAV	NNP
cord-259603-bh198xgl	438	24	nsp10-helicase	nsp10-helicase	NNP
cord-259603-bh198xgl	438	25	using	use	VBG
cord-259603-bh198xgl	438	26	reverse	reverse	JJ
cord-259603-bh198xgl	438	27	genetics	genetic	NNS
cord-259603-bh198xgl	438	28	,	,	,
cord-259603-bh198xgl	438	29	the	the	DT
cord-259603-bh198xgl	438	30	EAV	EAV	NNP
cord-259603-bh198xgl	438	31	nsp10	nsp10	NNP
cord-259603-bh198xgl	438	32	structure	structure	NN
cord-259603-bh198xgl	438	33	,	,	,
cord-259603-bh198xgl	438	34	and	and	CC
cord-259603-bh198xgl	438	35	advanced	advanced	JJ
cord-259603-bh198xgl	438	36	bioinformatics	bioinformatics	NN
cord-259603-bh198xgl	438	37	analyses	analysis	NNS
cord-259603-bh198xgl	438	38	together	together	RB
cord-259603-bh198xgl	438	39	have	have	VBP
cord-259603-bh198xgl	438	40	painted	paint	VBN
cord-259603-bh198xgl	438	41	a	a	DT
cord-259603-bh198xgl	438	42	picture	picture	NN
cord-259603-bh198xgl	438	43	of	of	IN
cord-259603-bh198xgl	438	44	an	an	DT
cord-259603-bh198xgl	438	45	enzyme	enzyme	NN
cord-259603-bh198xgl	438	46	that	that	WDT
cord-259603-bh198xgl	438	47	is	be	VBZ
cord-259603-bh198xgl	438	48	involved	involve	VBN
cord-259603-bh198xgl	438	49	in	in	IN
cord-259603-bh198xgl	438	50	multiple	multiple	JJ
cord-259603-bh198xgl	438	51	critical	critical	JJ
cord-259603-bh198xgl	438	52	steps	step	NNS
cord-259603-bh198xgl	438	53	of	of	IN
cord-259603-bh198xgl	438	54	the	the	DT
cord-259603-bh198xgl	438	55	viral	viral	JJ
cord-259603-bh198xgl	438	56	replicative	replicative	JJ
cord-259603-bh198xgl	438	57	cycle	cycle	NN
cord-259603-bh198xgl	438	58	.	.	.
cord-259603-bh198xgl	439	1	Space	space	NN
cord-259603-bh198xgl	439	2	limitations	limitation	NNS
cord-259603-bh198xgl	439	3	do	do	VBP
cord-259603-bh198xgl	439	4	not	not	RB
cord-259603-bh198xgl	439	5	allow	allow	VB
cord-259603-bh198xgl	439	6	an	an	DT
cord-259603-bh198xgl	439	7	in	in	IN
cord-259603-bh198xgl	439	8	-	-	HYPH
cord-259603-bh198xgl	439	9	depth	depth	NN
cord-259603-bh198xgl	439	10	discussion	discussion	NN
cord-259603-bh198xgl	439	11	of	of	IN
cord-259603-bh198xgl	439	12	all	all	DT
cord-259603-bh198xgl	439	13	of	of	IN
cord-259603-bh198xgl	439	14	these	these	DT
cord-259603-bh198xgl	439	15	(	(	-LRB-
cord-259603-bh198xgl	439	16	putative	putative	JJ
cord-259603-bh198xgl	439	17	)	)	-RRB-
cord-259603-bh198xgl	439	18	functions	function	NNS
cord-259603-bh198xgl	439	19	,	,	,
cord-259603-bh198xgl	439	20	which	which	WDT
cord-259603-bh198xgl	439	21	-	-	HYPH
cord-259603-bh198xgl	439	22	based	base	VBN
cord-259603-bh198xgl	439	23	on	on	IN
cord-259603-bh198xgl	439	24	EAV	EAV	NNP
cord-259603-bh198xgl	440	1	nsp10	nsp10	NNP
cord-259603-bh198xgl	440	2	studies	study	NNS
cord-259603-bh198xgl	440	3	-	-	:
cord-259603-bh198xgl	440	4	may	may	MD
cord-259603-bh198xgl	440	5	include	include	VB
cord-259603-bh198xgl	440	6	a	a	DT
cord-259603-bh198xgl	440	7	poorly	poorly	RB
cord-259603-bh198xgl	440	8	characterized	characterize	VBN
cord-259603-bh198xgl	440	9	role	role	NN
cord-259603-bh198xgl	440	10	in	in	IN
cord-259603-bh198xgl	440	11	virion	virion	NN
cord-259603-bh198xgl	440	12	biogenesis	biogenesis	NN
cord-259603-bh198xgl	440	13	(	(	-LRB-
cord-259603-bh198xgl	440	14	van	van	NNP
cord-259603-bh198xgl	440	15	Dinten	Dinten	NNP
cord-259603-bh198xgl	440	16	et	et	FW
cord-259603-bh198xgl	440	17	al	al	NNP
cord-259603-bh198xgl	440	18	.	.	NNP
cord-259603-bh198xgl	440	19	,	,	,
cord-259603-bh198xgl	440	20	2000	2000	CD
cord-259603-bh198xgl	440	21	)	)	-RRB-
cord-259603-bh198xgl	440	22	,	,	,
cord-259603-bh198xgl	440	23	not	not	RB
cord-259603-bh198xgl	440	24	unlike	unlike	IN
cord-259603-bh198xgl	440	25	what	what	WP
cord-259603-bh198xgl	440	26	was	be	VBD
cord-259603-bh198xgl	440	27	uncovered	uncover	VBN
cord-259603-bh198xgl	440	28	for	for	IN
cord-259603-bh198xgl	440	29	,	,	,
cord-259603-bh198xgl	440	30	e.g.	e.g.	RB
cord-259603-bh198xgl	440	31	,	,	,
cord-259603-bh198xgl	440	32	the	the	DT
cord-259603-bh198xgl	440	33	helicase	helicase	NN
cord-259603-bh198xgl	440	34	-	-	HYPH
cord-259603-bh198xgl	440	35	containing	contain	VBG
cord-259603-bh198xgl	440	36	NS3	ns3	RB
cord-259603-bh198xgl	440	37	protein	protein	NN
cord-259603-bh198xgl	440	38	of	of	IN
cord-259603-bh198xgl	440	39	flaviviruses	flavivirus	NNS
cord-259603-bh198xgl	441	1	(	(	-LRB-
cord-259603-bh198xgl	441	2	Liu	Liu	NNP
cord-259603-bh198xgl	441	3	et	et	NNP
cord-259603-bh198xgl	441	4	al	al	NNP
cord-259603-bh198xgl	441	5	.	.	.
cord-259603-bh198xgl	442	1	,	,	,
cord-259603-bh198xgl	442	2	2002	2002	CD
cord-259603-bh198xgl	442	3	;	;	:
cord-259603-bh198xgl	442	4	Ma	Ma	NNP
cord-259603-bh198xgl	442	5	et	et	NNP
cord-259603-bh198xgl	442	6	al	al	NNP
cord-259603-bh198xgl	442	7	.	.	NNP
cord-259603-bh198xgl	442	8	,	,	,
cord-259603-bh198xgl	442	9	2008	2008	CD
cord-259603-bh198xgl	442	10	)	)	-RRB-
cord-259603-bh198xgl	442	11	.	.	.
cord-259603-bh198xgl	443	1	Likewise	likewise	RB
cord-259603-bh198xgl	443	2	,	,	,
cord-259603-bh198xgl	443	3	we	-PRON-	PRP
cord-259603-bh198xgl	443	4	will	will	MD
cord-259603-bh198xgl	443	5	not	not	RB
cord-259603-bh198xgl	443	6	discuss	discuss	VB
cord-259603-bh198xgl	443	7	the	the	DT
cord-259603-bh198xgl	443	8	first	first	JJ
cord-259603-bh198xgl	443	9	reports	report	NNS
cord-259603-bh198xgl	443	10	on	on	IN
cord-259603-bh198xgl	443	11	possible	possible	JJ
cord-259603-bh198xgl	443	12	interactions	interaction	NNS
cord-259603-bh198xgl	443	13	with	with	IN
cord-259603-bh198xgl	443	14	host	host	NN
cord-259603-bh198xgl	443	15	proteins	protein	NNS
cord-259603-bh198xgl	443	16	,	,	,
cord-259603-bh198xgl	443	17	such	such	JJ
cord-259603-bh198xgl	443	18	as	as	IN
cord-259603-bh198xgl	443	19	the	the	DT
cord-259603-bh198xgl	443	20	Ddx5	Ddx5	NNP
cord-259603-bh198xgl	443	21	helicase	helicase	NN
cord-259603-bh198xgl	443	22	(	(	-LRB-
cord-259603-bh198xgl	443	23	for	for	IN
cord-259603-bh198xgl	443	24	SARS	SARS	NNP
cord-259603-bh198xgl	443	25	-	-	HYPH
cord-259603-bh198xgl	443	26	CoV	CoV	NNP
cord-259603-bh198xgl	443	27	nsp13	nsp13	NNP
cord-259603-bh198xgl	443	28	;	;	:
cord-259603-bh198xgl	443	29	Chen	Chen	NNP
cord-259603-bh198xgl	443	30	et	et	NNP
cord-259603-bh198xgl	443	31	al	al	NNP
cord-259603-bh198xgl	443	32	.	.	NNP
cord-259603-bh198xgl	443	33	,	,	,
cord-259603-bh198xgl	443	34	2009b	2009b	CD
cord-259603-bh198xgl	443	35	)	)	-RRB-
cord-259603-bh198xgl	443	36	and	and	CC
cord-259603-bh198xgl	443	37	polymerase	polymerase	NN
cord-259603-bh198xgl	443	38	δ	δ	NN
cord-259603-bh198xgl	443	39	(	(	-LRB-
cord-259603-bh198xgl	443	40	for	for	IN
cord-259603-bh198xgl	443	41	IBV	IBV	NNP
cord-259603-bh198xgl	443	42	nsp13	nsp13	''
cord-259603-bh198xgl	443	43	;	;	:
cord-259603-bh198xgl	443	44	Xu	Xu	NNP
cord-259603-bh198xgl	443	45	et	et	NNP
cord-259603-bh198xgl	443	46	al	al	NNP
cord-259603-bh198xgl	443	47	.	.	NNP
cord-259603-bh198xgl	443	48	,	,	,
cord-259603-bh198xgl	443	49	2011	2011	CD
cord-259603-bh198xgl	443	50	)	)	-RRB-
cord-259603-bh198xgl	443	51	.	.	.
cord-259603-bh198xgl	444	1	Instead	instead	RB
cord-259603-bh198xgl	444	2	,	,	,
cord-259603-bh198xgl	444	3	we	-PRON-	PRP
cord-259603-bh198xgl	444	4	will	will	MD
cord-259603-bh198xgl	444	5	focus	focus	VB
cord-259603-bh198xgl	444	6	on	on	IN
cord-259603-bh198xgl	444	7	the	the	DT
cord-259603-bh198xgl	444	8	most	most	RBS
cord-259603-bh198xgl	444	9	significant	significant	JJ
cord-259603-bh198xgl	444	10	findings	finding	NNS
cord-259603-bh198xgl	444	11	related	relate	VBN
cord-259603-bh198xgl	444	12	to	to	IN
cord-259603-bh198xgl	444	13	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	444	14	helicase	helicase	NNP
cord-259603-bh198xgl	444	15	functions	function	NNS
cord-259603-bh198xgl	444	16	in	in	IN
cord-259603-bh198xgl	444	17	RNA	RNA	NNP
cord-259603-bh198xgl	444	18	synthesis	synthesis	NN
cord-259603-bh198xgl	444	19	and	and	CC
cord-259603-bh198xgl	444	20	processing	processing	NN
cord-259603-bh198xgl	444	21	,	,	,
cord-259603-bh198xgl	444	22	specifically	specifically	RB
cord-259603-bh198xgl	444	23	(	(	-LRB-
cord-259603-bh198xgl	444	24	i	i	NN
cord-259603-bh198xgl	444	25	)	)	-RRB-
cord-259603-bh198xgl	444	26	genome	genome	NN
cord-259603-bh198xgl	444	27	replication	replication	NN
cord-259603-bh198xgl	444	28	,	,	,
cord-259603-bh198xgl	444	29	(	(	-LRB-
cord-259603-bh198xgl	444	30	ii	ii	NN
cord-259603-bh198xgl	444	31	)	)	-RRB-
cord-259603-bh198xgl	444	32	transcription	transcription	NN
cord-259603-bh198xgl	444	33	of	of	IN
cord-259603-bh198xgl	444	34	subgenomic	subgenomic	NNP
cord-259603-bh198xgl	444	35	mRNAs	mRNAs	NNPS
cord-259603-bh198xgl	444	36	,	,	,
cord-259603-bh198xgl	444	37	(	(	-LRB-
cord-259603-bh198xgl	444	38	iii	iii	NN
cord-259603-bh198xgl	444	39	)	)	-RRB-
cord-259603-bh198xgl	445	1	mRNA	mrna	NN
cord-259603-bh198xgl	445	2	capping	capping	NN
cord-259603-bh198xgl	445	3	,	,	,
cord-259603-bh198xgl	445	4	and	and	CC
cord-259603-bh198xgl	445	5	(	(	-LRB-
cord-259603-bh198xgl	445	6	iv	iv	LS
cord-259603-bh198xgl	445	7	)	)	-RRB-
cord-259603-bh198xgl	445	8	posttranscriptional	posttranscriptional	NNP
cord-259603-bh198xgl	445	9	mRNA	mRNA	NNP
cord-259603-bh198xgl	445	10	quality	quality	NNP
cord-259603-bh198xgl	445	11	control	control	NN
cord-259603-bh198xgl	445	12	.	.	.
cord-259603-bh198xgl	446	1	The	the	DT
cord-259603-bh198xgl	446	2	presumed	presumed	JJ
cord-259603-bh198xgl	446	3	"	"	``
cord-259603-bh198xgl	446	4	default	default	NN
cord-259603-bh198xgl	446	5	"	"	''
cord-259603-bh198xgl	446	6	function	function	NN
cord-259603-bh198xgl	446	7	of	of	IN
cord-259603-bh198xgl	446	8	+	+	SYM
cord-259603-bh198xgl	446	9	RNA	RNA	NNP
cord-259603-bh198xgl	446	10	viral	viral	JJ
cord-259603-bh198xgl	446	11	helicases	helicase	NNS
cord-259603-bh198xgl	446	12	is	be	VBZ
cord-259603-bh198xgl	446	13	to	to	TO
cord-259603-bh198xgl	446	14	cooperate	cooperate	VB
cord-259603-bh198xgl	446	15	with	with	IN
cord-259603-bh198xgl	446	16	the	the	DT
cord-259603-bh198xgl	446	17	viral	viral	JJ
cord-259603-bh198xgl	446	18	RdRp	RdRp	NNP
cord-259603-bh198xgl	446	19	to	to	TO
cord-259603-bh198xgl	446	20	achieve	achieve	VB
cord-259603-bh198xgl	446	21	the	the	DT
cord-259603-bh198xgl	446	22	efficient	efficient	JJ
cord-259603-bh198xgl	446	23	amplification	amplification	NN
cord-259603-bh198xgl	446	24	of	of	IN
cord-259603-bh198xgl	446	25	the	the	DT
cord-259603-bh198xgl	446	26	genome	genome	NN
cord-259603-bh198xgl	446	27	.	.	.
cord-259603-bh198xgl	447	1	In	in	IN
cord-259603-bh198xgl	447	2	this	this	DT
cord-259603-bh198xgl	447	3	context	context	NN
cord-259603-bh198xgl	447	4	,	,	,
cord-259603-bh198xgl	447	5	helicases	helicase	NNS
cord-259603-bh198xgl	447	6	are	be	VBP
cord-259603-bh198xgl	447	7	presumed	presume	VBN
cord-259603-bh198xgl	447	8	to	to	TO
cord-259603-bh198xgl	447	9	promote	promote	VB
cord-259603-bh198xgl	447	10	RdRp	RdRp	NNP
cord-259603-bh198xgl	447	11	processivity	processivity	NN
cord-259603-bh198xgl	447	12	by	by	IN
cord-259603-bh198xgl	447	13	opening	open	VBG
cord-259603-bh198xgl	447	14	up	up	RP
cord-259603-bh198xgl	447	15	the	the	DT
cord-259603-bh198xgl	447	16	double	double	RB
cord-259603-bh198xgl	447	17	-	-	HYPH
cord-259603-bh198xgl	447	18	stranded	strand	VBN
cord-259603-bh198xgl	447	19	RNA	RNA	NNP
cord-259603-bh198xgl	447	20	intermediates	intermediate	NNS
cord-259603-bh198xgl	447	21	of	of	IN
cord-259603-bh198xgl	447	22	viral	viral	JJ
cord-259603-bh198xgl	447	23	replication	replication	NN
cord-259603-bh198xgl	447	24	,	,	,
cord-259603-bh198xgl	447	25	and	and	CC
cord-259603-bh198xgl	447	26	possibly	possibly	RB
cord-259603-bh198xgl	447	27	also	also	RB
cord-259603-bh198xgl	447	28	by	by	IN
cord-259603-bh198xgl	447	29	removing	remove	VBG
cord-259603-bh198xgl	447	30	RNA	RNA	NNP
cord-259603-bh198xgl	447	31	secondary	secondary	JJ
cord-259603-bh198xgl	447	32	structures	structure	NNS
cord-259603-bh198xgl	447	33	in	in	IN
cord-259603-bh198xgl	447	34	single	single	RB
cord-259603-bh198xgl	447	35	-	-	HYPH
cord-259603-bh198xgl	447	36	stranded	strand	VBN
cord-259603-bh198xgl	447	37	template	template	NN
cord-259603-bh198xgl	447	38	strands	strand	NNS
cord-259603-bh198xgl	447	39	(	(	-LRB-
cord-259603-bh198xgl	447	40	Kadare	Kadare	NNP
cord-259603-bh198xgl	447	41	and	and	CC
cord-259603-bh198xgl	447	42	Haenni	Haenni	NNP
cord-259603-bh198xgl	447	43	,	,	,
cord-259603-bh198xgl	447	44	1997	1997	CD
cord-259603-bh198xgl	447	45	)	)	-RRB-
cord-259603-bh198xgl	447	46	.	.	.
cord-259603-bh198xgl	448	1	In	in	IN
cord-259603-bh198xgl	448	2	this	this	DT
cord-259603-bh198xgl	448	3	light	light	NN
cord-259603-bh198xgl	448	4	,	,	,
cord-259603-bh198xgl	448	5	reports	report	NNS
cord-259603-bh198xgl	448	6	on	on	IN
cord-259603-bh198xgl	448	7	molecular	molecular	JJ
cord-259603-bh198xgl	448	8	interactions	interaction	NNS
cord-259603-bh198xgl	448	9	between	between	IN
cord-259603-bh198xgl	448	10	the	the	DT
cord-259603-bh198xgl	448	11	CoV	cov	NN
cord-259603-bh198xgl	448	12	RdRp	RdRp	NNP
cord-259603-bh198xgl	448	13	(	(	-LRB-
cord-259603-bh198xgl	448	14	nsp12	nsp12	CD
cord-259603-bh198xgl	448	15	)	)	-RRB-
cord-259603-bh198xgl	448	16	and	and	CC
cord-259603-bh198xgl	448	17	helicase	helicase	NNP
cord-259603-bh198xgl	448	18	(	(	-LRB-
cord-259603-bh198xgl	448	19	nsp13	nsp13	NNP
cord-259603-bh198xgl	448	20	)	)	-RRB-
cord-259603-bh198xgl	448	21	were	be	VBD
cord-259603-bh198xgl	448	22	not	not	RB
cord-259603-bh198xgl	448	23	unexpected	unexpected	JJ
cord-259603-bh198xgl	448	24	von	von	NNP
cord-259603-bh198xgl	448	25	Brunn	Brunn	NNP
cord-259603-bh198xgl	448	26	et	et	NNP
cord-259603-bh198xgl	448	27	al	al	NNP
cord-259603-bh198xgl	448	28	.	.	NNP
cord-259603-bh198xgl	448	29	,	,	,
cord-259603-bh198xgl	448	30	2007	2007	CD
cord-259603-bh198xgl	448	31	)	)	-RRB-
cord-259603-bh198xgl	448	32	.	.	.
cord-259603-bh198xgl	449	1	The	the	DT
cord-259603-bh198xgl	449	2	same	same	JJ
cord-259603-bh198xgl	449	3	holds	hold	VBZ
cord-259603-bh198xgl	449	4	true	true	JJ
cord-259603-bh198xgl	449	5	for	for	IN
cord-259603-bh198xgl	449	6	the	the	DT
cord-259603-bh198xgl	449	7	observation	observation	NN
cord-259603-bh198xgl	449	8	that	that	IN
cord-259603-bh198xgl	449	9	SARS	SARS	NNP
cord-259603-bh198xgl	449	10	-	-	HYPH
cord-259603-bh198xgl	449	11	CoV	CoV	NNP
cord-259603-bh198xgl	449	12	nsp12	nsp12	NNS
cord-259603-bh198xgl	449	13	can	can	MD
cord-259603-bh198xgl	449	14	stimulate	stimulate	VB
cord-259603-bh198xgl	449	15	the	the	DT
cord-259603-bh198xgl	449	16	in	in	FW
cord-259603-bh198xgl	449	17	vitro	vitro	FW
cord-259603-bh198xgl	449	18	helicase	helicase	NN
cord-259603-bh198xgl	449	19	activity	activity	NN
cord-259603-bh198xgl	449	20	of	of	IN
cord-259603-bh198xgl	449	21	nsp13	nsp13	NNP
cord-259603-bh198xgl	449	22	(	(	-LRB-
cord-259603-bh198xgl	449	23	Adedeji	Adedeji	NNP
cord-259603-bh198xgl	449	24	et	et	NNP
cord-259603-bh198xgl	449	25	al	al	NNP
cord-259603-bh198xgl	449	26	.	.	NNP
cord-259603-bh198xgl	449	27	,	,	,
cord-259603-bh198xgl	449	28	2012a	2012a	CD
cord-259603-bh198xgl	449	29	)	)	-RRB-
cord-259603-bh198xgl	449	30	and	and	CC
cord-259603-bh198xgl	449	31	for	for	IN
cord-259603-bh198xgl	449	32	the	the	DT
cord-259603-bh198xgl	449	33	fact	fact	NN
cord-259603-bh198xgl	449	34	that	that	IN
cord-259603-bh198xgl	449	35	both	both	DT
cord-259603-bh198xgl	449	36	nsp12	nsp12	CD
cord-259603-bh198xgl	449	37	and	and	CC
cord-259603-bh198xgl	449	38	nsp13	nsp13	CD
cord-259603-bh198xgl	450	1	(	(	-LRB-
cord-259603-bh198xgl	450	2	like	like	IN
cord-259603-bh198xgl	450	3	most	most	JJS
cord-259603-bh198xgl	450	4	other	other	JJ
cord-259603-bh198xgl	450	5	CoV	cov	NN
cord-259603-bh198xgl	450	6	replicase	replicase	NNP
cord-259603-bh198xgl	450	7	cleavage	cleavage	NN
cord-259603-bh198xgl	450	8	products	product	NNS
cord-259603-bh198xgl	450	9	)	)	-RRB-
cord-259603-bh198xgl	450	10	associate	associate	VBP
cord-259603-bh198xgl	450	11	with	with	IN
cord-259603-bh198xgl	450	12	the	the	DT
cord-259603-bh198xgl	450	13	membranous	membranous	JJ
cord-259603-bh198xgl	450	14	replication	replication	NN
cord-259603-bh198xgl	450	15	organelles	organelle	NNS
cord-259603-bh198xgl	450	16	in	in	IN
cord-259603-bh198xgl	450	17	nidovirus	nidovirus	NN
cord-259603-bh198xgl	450	18	-	-	HYPH
cord-259603-bh198xgl	450	19	infected	infect	VBN
cord-259603-bh198xgl	450	20	cells	cell	NNS
cord-259603-bh198xgl	451	1	(	(	-LRB-
cord-259603-bh198xgl	451	2	Denison	Denison	NNP
cord-259603-bh198xgl	451	3	et	et	NNP
cord-259603-bh198xgl	451	4	al	al	NNP
cord-259603-bh198xgl	451	5	.	.	NNP
cord-259603-bh198xgl	451	6	,	,	,
cord-259603-bh198xgl	451	7	1999	1999	CD
cord-259603-bh198xgl	452	1	;	;	:
cord-259603-bh198xgl	452	2	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	452	3	et	et	NNP
cord-259603-bh198xgl	452	4	al	al	NNP
cord-259603-bh198xgl	452	5	.	.	.
cord-259603-bh198xgl	453	1	,	,	,
cord-259603-bh198xgl	453	2	2004b	2004b	CD
cord-259603-bh198xgl	453	3	;	;	:
cord-259603-bh198xgl	453	4	Knoops	Knoops	NNP
cord-259603-bh198xgl	453	5	et	et	NNP
cord-259603-bh198xgl	453	6	al	al	NNP
cord-259603-bh198xgl	453	7	.	.	NNP
cord-259603-bh198xgl	453	8	,	,	,
cord-259603-bh198xgl	453	9	2008	2008	CD
cord-259603-bh198xgl	453	10	)	)	-RRB-
cord-259603-bh198xgl	453	11	.	.	.
cord-259603-bh198xgl	454	1	In	in	IN
cord-259603-bh198xgl	454	2	spite	spite	NN
cord-259603-bh198xgl	454	3	of	of	IN
cord-259603-bh198xgl	454	4	all	all	PDT
cord-259603-bh198xgl	454	5	these	these	DT
cord-259603-bh198xgl	454	6	indications	indication	NNS
cord-259603-bh198xgl	454	7	for	for	IN
cord-259603-bh198xgl	454	8	RdRp	rdrp	NN
cord-259603-bh198xgl	454	9	-	-	HYPH
cord-259603-bh198xgl	454	10	helicase	helicase	NN
cord-259603-bh198xgl	454	11	interplay	interplay	NN
cord-259603-bh198xgl	454	12	,	,	,
cord-259603-bh198xgl	454	13	the	the	DT
cord-259603-bh198xgl	454	14	polarity	polarity	NN
cord-259603-bh198xgl	454	15	of	of	IN
cord-259603-bh198xgl	454	16	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	454	17	helicase	helicase	NNP
cord-259603-bh198xgl	454	18	-	-	HYPH
cord-259603-bh198xgl	454	19	mediated	mediate	VBN
cord-259603-bh198xgl	454	20	unwinding	unwinding	NN
cord-259603-bh198xgl	454	21	(	(	-LRB-
cord-259603-bh198xgl	454	22	5	5	CD
cord-259603-bh198xgl	454	23	0	0	CD
cord-259603-bh198xgl	454	24	-to-3	-to-3	CD
cord-259603-bh198xgl	454	25	0	0	NFP
cord-259603-bh198xgl	454	26	)	)	-RRB-
cord-259603-bh198xgl	454	27	remains	remain	VBZ
cord-259603-bh198xgl	454	28	a	a	DT
cord-259603-bh198xgl	454	29	major	major	JJ
cord-259603-bh198xgl	454	30	conundrum	conundrum	NN
cord-259603-bh198xgl	454	31	,	,	,
cord-259603-bh198xgl	454	32	as	as	IN
cord-259603-bh198xgl	454	33	it	-PRON-	PRP
cord-259603-bh198xgl	454	34	is	be	VBZ
cord-259603-bh198xgl	454	35	opposite	opposite	JJ
cord-259603-bh198xgl	454	36	to	to	IN
cord-259603-bh198xgl	454	37	the	the	DT
cord-259603-bh198xgl	454	38	polarities	polarity	NNS
cord-259603-bh198xgl	454	39	of	of	IN
cord-259603-bh198xgl	454	40	the	the	DT
cord-259603-bh198xgl	454	41	RdRp	RdRp	NNP
cord-259603-bh198xgl	454	42	and	and	CC
cord-259603-bh198xgl	454	43	many	many	JJ
cord-259603-bh198xgl	454	44	other	other	JJ
cord-259603-bh198xgl	454	45	+	+	.
cord-259603-bh198xgl	455	1	RNA	RNA	NNP
cord-259603-bh198xgl	455	2	helicases	helicase	NNS
cord-259603-bh198xgl	455	3	,	,	,
cord-259603-bh198xgl	455	4	which	which	WDT
cord-259603-bh198xgl	455	5	move	move	VBP
cord-259603-bh198xgl	455	6	in	in	IN
cord-259603-bh198xgl	455	7	a	a	DT
cord-259603-bh198xgl	455	8	3	3	CD
cord-259603-bh198xgl	455	9	0	0	CD
cord-259603-bh198xgl	455	10	-to-5	-to-5	ADD
cord-259603-bh198xgl	455	11	0	0	CD
cord-259603-bh198xgl	455	12	direction	direction	NN
cord-259603-bh198xgl	455	13	on	on	IN
cord-259603-bh198xgl	455	14	the	the	DT
cord-259603-bh198xgl	455	15	RNA	RNA	NNP
cord-259603-bh198xgl	455	16	strand	strand	NN
cord-259603-bh198xgl	455	17	they	-PRON-	PRP
cord-259603-bh198xgl	455	18	initially	initially	RB
cord-259603-bh198xgl	455	19	bind	bind	VBP
cord-259603-bh198xgl	455	20	to	to	IN
cord-259603-bh198xgl	455	21	(	(	-LRB-
cord-259603-bh198xgl	455	22	Seybert	Seybert	NNP
cord-259603-bh198xgl	455	23	et	et	NNP
cord-259603-bh198xgl	455	24	al	al	NNP
cord-259603-bh198xgl	455	25	.	.	NNP
cord-259603-bh198xgl	455	26	,	,	,
cord-259603-bh198xgl	455	27	2000a	2000a	CD
cord-259603-bh198xgl	455	28	)	)	-RRB-
cord-259603-bh198xgl	455	29	.	.	.
cord-259603-bh198xgl	456	1	This	this	DT
cord-259603-bh198xgl	456	2	strongly	strongly	RB
cord-259603-bh198xgl	456	3	suggests	suggest	VBZ
cord-259603-bh198xgl	456	4	that	that	IN
cord-259603-bh198xgl	456	5	the	the	DT
cord-259603-bh198xgl	456	6	two	two	CD
cord-259603-bh198xgl	456	7	enzymes	enzyme	NNS
cord-259603-bh198xgl	456	8	can	can	MD
cord-259603-bh198xgl	456	9	not	not	RB
cord-259603-bh198xgl	456	10	simply	simply	RB
cord-259603-bh198xgl	456	11	operate	operate	VB
cord-259603-bh198xgl	456	12	as	as	IN
cord-259603-bh198xgl	456	13	a	a	DT
cord-259603-bh198xgl	456	14	tandem	tandem	NN
cord-259603-bh198xgl	456	15	that	that	WDT
cord-259603-bh198xgl	456	16	moves	move	VBZ
cord-259603-bh198xgl	456	17	along	along	IN
cord-259603-bh198xgl	456	18	the	the	DT
cord-259603-bh198xgl	456	19	same	same	JJ
cord-259603-bh198xgl	456	20	template	template	NN
cord-259603-bh198xgl	456	21	strand	strand	NN
cord-259603-bh198xgl	456	22	while	while	IN
cord-259603-bh198xgl	456	23	copying	copy	VBG
cord-259603-bh198xgl	456	24	it	-PRON-	PRP
cord-259603-bh198xgl	456	25	,	,	,
cord-259603-bh198xgl	456	26	a	a	DT
cord-259603-bh198xgl	456	27	consideration	consideration	NN
cord-259603-bh198xgl	456	28	that	that	WDT
cord-259603-bh198xgl	456	29	also	also	RB
cord-259603-bh198xgl	456	30	applies	apply	VBZ
cord-259603-bh198xgl	456	31	to	to	IN
cord-259603-bh198xgl	456	32	the	the	DT
cord-259603-bh198xgl	456	33	SF1B	sf1b	NN
cord-259603-bh198xgl	456	34	helicase	helicase	NN
cord-259603-bh198xgl	456	35	employed	employ	VBN
cord-259603-bh198xgl	456	36	by	by	IN
cord-259603-bh198xgl	456	37	alphaviruses	alphavirus	NNS
cord-259603-bh198xgl	456	38	.	.	.
cord-259603-bh198xgl	457	1	This	this	DT
cord-259603-bh198xgl	457	2	problem	problem	NN
cord-259603-bh198xgl	457	3	could	could	MD
cord-259603-bh198xgl	457	4	be	be	VB
cord-259603-bh198xgl	457	5	resolved	resolve	VBN
cord-259603-bh198xgl	457	6	if	if	IN
cord-259603-bh198xgl	457	7	RdRp	RdRp	NNP
cord-259603-bh198xgl	457	8	and	and	CC
cord-259603-bh198xgl	457	9	helicase	helicase	NNP
cord-259603-bh198xgl	457	10	would	would	MD
cord-259603-bh198xgl	457	11	move	move	VB
cord-259603-bh198xgl	457	12	along	along	IN
cord-259603-bh198xgl	457	13	different	different	JJ
cord-259603-bh198xgl	457	14	strands	strand	NNS
cord-259603-bh198xgl	457	15	of	of	IN
cord-259603-bh198xgl	457	16	the	the	DT
cord-259603-bh198xgl	457	17	same	same	JJ
cord-259603-bh198xgl	457	18	RNA	RNA	NNP
cord-259603-bh198xgl	457	19	duplex	duplex	NN
cord-259603-bh198xgl	457	20	,	,	,
cord-259603-bh198xgl	457	21	which	which	WDT
cord-259603-bh198xgl	457	22	might	may	MD
cord-259603-bh198xgl	457	23	allow	allow	VB
cord-259603-bh198xgl	457	24	the	the	DT
cord-259603-bh198xgl	457	25	helicase	helicase	NN
cord-259603-bh198xgl	457	26	to	to	TO
cord-259603-bh198xgl	457	27	separate	separate	VB
cord-259603-bh198xgl	457	28	the	the	DT
cord-259603-bh198xgl	457	29	two	two	CD
cord-259603-bh198xgl	457	30	strands	strand	NNS
cord-259603-bh198xgl	457	31	and	and	CC
cord-259603-bh198xgl	457	32	provide	provide	VB
cord-259603-bh198xgl	457	33	a	a	DT
cord-259603-bh198xgl	457	34	single	single	JJ
cord-259603-bh198xgl	457	35	-	-	HYPH
cord-259603-bh198xgl	457	36	stranded	strand	VBN
cord-259603-bh198xgl	457	37	template	template	NN
cord-259603-bh198xgl	457	38	to	to	TO
cord-259603-bh198xgl	457	39	be	be	VB
cord-259603-bh198xgl	457	40	copied	copy	VBN
cord-259603-bh198xgl	457	41	by	by	IN
cord-259603-bh198xgl	457	42	the	the	DT
cord-259603-bh198xgl	457	43	RdRp	RdRp	NNP
cord-259603-bh198xgl	458	1	(	(	-LRB-
cord-259603-bh198xgl	458	2	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	458	3	et	et	NNP
cord-259603-bh198xgl	458	4	al	al	NNP
cord-259603-bh198xgl	458	5	.	.	NNP
cord-259603-bh198xgl	458	6	,	,	,
cord-259603-bh198xgl	458	7	2015c	2015c	CD
cord-259603-bh198xgl	458	8	)	)	-RRB-
cord-259603-bh198xgl	458	9	.	.	.
cord-259603-bh198xgl	459	1	Also	also	RB
cord-259603-bh198xgl	459	2	,	,	,
cord-259603-bh198xgl	459	3	it	-PRON-	PRP
cord-259603-bh198xgl	459	4	is	be	VBZ
cord-259603-bh198xgl	459	5	tempting	tempt	VBG
cord-259603-bh198xgl	459	6	to	to	TO
cord-259603-bh198xgl	459	7	speculate	speculate	VB
cord-259603-bh198xgl	459	8	that	that	IN
cord-259603-bh198xgl	459	9	the	the	DT
cord-259603-bh198xgl	459	10	helicase	helicase	NN
cord-259603-bh198xgl	459	11	,	,	,
cord-259603-bh198xgl	459	12	by	by	IN
cord-259603-bh198xgl	459	13	trailing	trail	VBG
cord-259603-bh198xgl	459	14	along	along	IN
cord-259603-bh198xgl	459	15	the	the	DT
cord-259603-bh198xgl	459	16	nascent	nascent	JJ
cord-259603-bh198xgl	459	17	strand	strand	NN
cord-259603-bh198xgl	459	18	(	(	-LRB-
cord-259603-bh198xgl	459	19	following	follow	VBG
cord-259603-bh198xgl	459	20	the	the	DT
cord-259603-bh198xgl	459	21	RdRp	RdRp	NNP
cord-259603-bh198xgl	459	22	at	at	IN
cord-259603-bh198xgl	459	23	a	a	DT
cord-259603-bh198xgl	459	24	certain	certain	JJ
cord-259603-bh198xgl	459	25	and	and	CC
cord-259603-bh198xgl	459	26	,	,	,
cord-259603-bh198xgl	459	27	possibly	possibly	RB
cord-259603-bh198xgl	459	28	,	,	,
cord-259603-bh198xgl	459	29	somewhat	somewhat	RB
cord-259603-bh198xgl	459	30	flexible	flexible	JJ
cord-259603-bh198xgl	459	31	distance	distance	NN
cord-259603-bh198xgl	459	32	)	)	-RRB-
cord-259603-bh198xgl	459	33	,	,	,
cord-259603-bh198xgl	459	34	provides	provide	VBZ
cord-259603-bh198xgl	459	35	(	(	-LRB-
cord-259603-bh198xgl	459	36	i.e.	i.e.	FW
cord-259603-bh198xgl	459	37	,	,	,
cord-259603-bh198xgl	459	38	leaves	leave	VBZ
cord-259603-bh198xgl	459	39	behind	behind	RB
cord-259603-bh198xgl	459	40	)	)	-RRB-
cord-259603-bh198xgl	459	41	a	a	DT
cord-259603-bh198xgl	459	42	single	single	RB
cord-259603-bh198xgl	459	43	-	-	HYPH
cord-259603-bh198xgl	459	44	stranded	strand	VBN
cord-259603-bh198xgl	459	45	template	template	NN
cord-259603-bh198xgl	459	46	,	,	,
cord-259603-bh198xgl	459	47	thus	thus	RB
cord-259603-bh198xgl	459	48	facilitating	facilitate	VBG
cord-259603-bh198xgl	459	49	initiation	initiation	NN
cord-259603-bh198xgl	459	50	and	and	CC
cord-259603-bh198xgl	459	51	elongation	elongation	NN
cord-259603-bh198xgl	459	52	of	of	IN
cord-259603-bh198xgl	459	53	RNA	RNA	NNP
cord-259603-bh198xgl	459	54	synthesis	synthesis	NN
cord-259603-bh198xgl	459	55	by	by	IN
cord-259603-bh198xgl	459	56	the	the	DT
cord-259603-bh198xgl	459	57	next	next	JJ
cord-259603-bh198xgl	459	58	RTC	RTC	NNP
cord-259603-bh198xgl	459	59	.	.	.
cord-259603-bh198xgl	460	1	This	this	DT
cord-259603-bh198xgl	460	2	,	,	,
cord-259603-bh198xgl	460	3	for	for	IN
cord-259603-bh198xgl	460	4	example	example	NN
cord-259603-bh198xgl	460	5	,	,	,
cord-259603-bh198xgl	460	6	could	could	MD
cord-259603-bh198xgl	460	7	occur	occur	VB
cord-259603-bh198xgl	460	8	in	in	IN
cord-259603-bh198xgl	460	9	cases	case	NNS
cord-259603-bh198xgl	460	10	when	when	WRB
cord-259603-bh198xgl	460	11	multiple	multiple	JJ
cord-259603-bh198xgl	460	12	RTCs	RTCs	NNP
cord-259603-bh198xgl	460	13	act	act	NNP
cord-259603-bh198xgl	460	14	simultaneously	simultaneously	RB
cord-259603-bh198xgl	460	15	/	/	,
cord-259603-bh198xgl	460	16	consecutively	consecutively	RB
cord-259603-bh198xgl	460	17	on	on	IN
cord-259603-bh198xgl	460	18	the	the	DT
cord-259603-bh198xgl	460	19	same	same	JJ
cord-259603-bh198xgl	460	20	template	template	NN
cord-259603-bh198xgl	460	21	to	to	TO
cord-259603-bh198xgl	460	22	produce	produce	VB
cord-259603-bh198xgl	460	23	multiple	multiple	JJ
cord-259603-bh198xgl	460	24	plus	plus	JJ
cord-259603-bh198xgl	460	25	-	-	HYPH
cord-259603-bh198xgl	460	26	strand	strand	NN
cord-259603-bh198xgl	460	27	RNAs	rna	NNS
cord-259603-bh198xgl	460	28	from	from	IN
cord-259603-bh198xgl	460	29	the	the	DT
cord-259603-bh198xgl	460	30	same	same	JJ
cord-259603-bh198xgl	460	31	minus	minus	JJ
cord-259603-bh198xgl	460	32	-	-	HYPH
cord-259603-bh198xgl	460	33	strand	strand	NN
cord-259603-bh198xgl	460	34	template	template	NN
cord-259603-bh198xgl	460	35	,	,	,
cord-259603-bh198xgl	460	36	a	a	DT
cord-259603-bh198xgl	460	37	process	process	NN
cord-259603-bh198xgl	460	38	that	that	WDT
cord-259603-bh198xgl	460	39	is	be	VBZ
cord-259603-bh198xgl	460	40	generally	generally	RB
cord-259603-bh198xgl	460	41	thought	think	VBN
cord-259603-bh198xgl	460	42	to	to	TO
cord-259603-bh198xgl	460	43	add	add	VB
cord-259603-bh198xgl	460	44	to	to	IN
cord-259603-bh198xgl	460	45	the	the	DT
cord-259603-bh198xgl	460	46	large	large	JJ
cord-259603-bh198xgl	460	47	excess	excess	NN
cord-259603-bh198xgl	460	48	of	of	IN
cord-259603-bh198xgl	460	49	plus	plus	NN
cord-259603-bh198xgl	460	50	-	-	HYPH
cord-259603-bh198xgl	460	51	over	over	RP
cord-259603-bh198xgl	460	52	minus	minus	JJ
cord-259603-bh198xgl	460	53	-	-	HYPH
cord-259603-bh198xgl	460	54	strand	strand	NN
cord-259603-bh198xgl	460	55	RNAs	rna	NNS
cord-259603-bh198xgl	460	56	in	in	IN
cord-259603-bh198xgl	460	57	nidovirus	nidovirus	NN
cord-259603-bh198xgl	460	58	-	-	HYPH
cord-259603-bh198xgl	460	59	infected	infect	VBN
cord-259603-bh198xgl	460	60	cells	cell	NNS
cord-259603-bh198xgl	460	61	.	.	.
cord-259603-bh198xgl	461	1	Clearly	clearly	RB
cord-259603-bh198xgl	461	2	,	,	,
cord-259603-bh198xgl	461	3	significantly	significantly	RB
cord-259603-bh198xgl	461	4	more	more	JJR
cord-259603-bh198xgl	461	5	work	work	NN
cord-259603-bh198xgl	461	6	is	be	VBZ
cord-259603-bh198xgl	461	7	needed	need	VBN
cord-259603-bh198xgl	461	8	to	to	TO
cord-259603-bh198xgl	461	9	explore	explore	VB
cord-259603-bh198xgl	461	10	this	this	DT
cord-259603-bh198xgl	461	11	possibility	possibility	NN
cord-259603-bh198xgl	461	12	.	.	.
cord-259603-bh198xgl	462	1	Nidovirus	Nidovirus	NNP
cord-259603-bh198xgl	462	2	sg	sg	NNP
cord-259603-bh198xgl	462	3	mRNAs	mRNAs	NNP
cord-259603-bh198xgl	462	4	are	be	VBP
cord-259603-bh198xgl	462	5	each	each	DT
cord-259603-bh198xgl	462	6	produced	produce	VBN
cord-259603-bh198xgl	462	7	from	from	IN
cord-259603-bh198xgl	462	8	their	-PRON-	PRP$
cord-259603-bh198xgl	462	9	own	own	JJ
cord-259603-bh198xgl	462	10	subgenomelength	subgenomelength	NN
cord-259603-bh198xgl	462	11	minus	minus	JJ
cord-259603-bh198xgl	462	12	-	-	HYPH
cord-259603-bh198xgl	462	13	strand	strand	NN
cord-259603-bh198xgl	462	14	template	template	NN
cord-259603-bh198xgl	462	15	(	(	-LRB-
cord-259603-bh198xgl	462	16	see	see	VB
cord-259603-bh198xgl	462	17	Section	section	NN
cord-259603-bh198xgl	462	18	1	1	CD
cord-259603-bh198xgl	462	19	)	)	-RRB-
cord-259603-bh198xgl	462	20	.	.	.
cord-259603-bh198xgl	463	1	In	in	IN
cord-259603-bh198xgl	463	2	the	the	DT
cord-259603-bh198xgl	463	3	case	case	NN
cord-259603-bh198xgl	463	4	of	of	IN
cord-259603-bh198xgl	463	5	arteri	arteri	NN
cord-259603-bh198xgl	463	6	-	-	HYPH
cord-259603-bh198xgl	463	7	and	and	CC
cord-259603-bh198xgl	463	8	coronaviruses	coronaviruse	NNS
cord-259603-bh198xgl	463	9	,	,	,
cord-259603-bh198xgl	463	10	these	these	DT
cord-259603-bh198xgl	463	11	derive	derive	VBP
cord-259603-bh198xgl	463	12	from	from	IN
cord-259603-bh198xgl	463	13	a	a	DT
cord-259603-bh198xgl	463	14	process	process	NN
cord-259603-bh198xgl	463	15	of	of	IN
cord-259603-bh198xgl	463	16	discontinuous	discontinuous	JJ
cord-259603-bh198xgl	463	17	minus	minus	JJ
cord-259603-bh198xgl	463	18	-	-	HYPH
cord-259603-bh198xgl	463	19	strand	strand	NN
cord-259603-bh198xgl	463	20	RNA	RNA	NNP
cord-259603-bh198xgl	463	21	synthesis	synthesis	NN
cord-259603-bh198xgl	463	22	and	and	CC
cord-259603-bh198xgl	463	23	this	this	DT
cord-259603-bh198xgl	463	24	unique	unique	JJ
cord-259603-bh198xgl	463	25	mechanism	mechanism	NN
cord-259603-bh198xgl	463	26	likely	likely	RB
cord-259603-bh198xgl	463	27	requires	require	VBZ
cord-259603-bh198xgl	463	28	specific	specific	JJ
cord-259603-bh198xgl	463	29	functional	functional	JJ
cord-259603-bh198xgl	463	30	interactions	interaction	NNS
cord-259603-bh198xgl	463	31	between	between	IN
cord-259603-bh198xgl	463	32	(	(	-LRB-
cord-259603-bh198xgl	463	33	among	among	IN
cord-259603-bh198xgl	463	34	others	other	NNS
cord-259603-bh198xgl	463	35	)	)	-RRB-
cord-259603-bh198xgl	463	36	RdRp	RdRp	NNP
cord-259603-bh198xgl	463	37	and	and	CC
cord-259603-bh198xgl	463	38	helicase	helicase	NNP
cord-259603-bh198xgl	463	39	.	.	.
cord-259603-bh198xgl	464	1	These	these	DT
cord-259603-bh198xgl	464	2	interactions	interaction	NNS
cord-259603-bh198xgl	464	3	may	may	MD
cord-259603-bh198xgl	464	4	contribute	contribute	VB
cord-259603-bh198xgl	464	5	to	to	IN
cord-259603-bh198xgl	464	6	maintaining	maintain	VBG
cord-259603-bh198xgl	464	7	a	a	DT
cord-259603-bh198xgl	464	8	proper	proper	JJ
cord-259603-bh198xgl	464	9	balance	balance	NN
cord-259603-bh198xgl	464	10	between	between	IN
cord-259603-bh198xgl	464	11	continuous	continuous	JJ
cord-259603-bh198xgl	464	12	and	and	CC
cord-259603-bh198xgl	464	13	discontinuous	discontinuous	JJ
cord-259603-bh198xgl	464	14	minus	minus	JJ
cord-259603-bh198xgl	464	15	-	-	HYPH
cord-259603-bh198xgl	464	16	strand	strand	NN
cord-259603-bh198xgl	464	17	RNA	RNA	NNP
cord-259603-bh198xgl	464	18	synthesis	synthesis	NN
cord-259603-bh198xgl	464	19	,	,	,
cord-259603-bh198xgl	464	20	and	and	CC
cord-259603-bh198xgl	464	21	thus	thus	RB
cord-259603-bh198xgl	464	22	between	between	IN
cord-259603-bh198xgl	464	23	the	the	DT
cord-259603-bh198xgl	464	24	production	production	NN
cord-259603-bh198xgl	464	25	of	of	IN
cord-259603-bh198xgl	464	26	new	new	JJ
cord-259603-bh198xgl	464	27	genomes	genome	NNS
cord-259603-bh198xgl	464	28	and	and	CC
cord-259603-bh198xgl	464	29	sg	sg	NNP
cord-259603-bh198xgl	464	30	mRNAs	mRNAs	NNP
cord-259603-bh198xgl	464	31	.	.	.
cord-259603-bh198xgl	465	1	The	the	DT
cord-259603-bh198xgl	465	2	serendipitous	serendipitous	JJ
cord-259603-bh198xgl	465	3	identification	identification	NN
cord-259603-bh198xgl	465	4	of	of	IN
cord-259603-bh198xgl	465	5	an	an	DT
cord-259603-bh198xgl	465	6	arterivirus	arterivirus	NN
cord-259603-bh198xgl	465	7	nsp10-ZBD	nsp10-ZBD	NNP
cord-259603-bh198xgl	465	8	mutation	mutation	NN
cord-259603-bh198xgl	465	9	(	(	-LRB-
cord-259603-bh198xgl	465	10	Ser-59	Ser-59	NNP
cord-259603-bh198xgl	465	11	!	!	.
cord-259603-bh198xgl	465	12	Pro	Pro	NNP
cord-259603-bh198xgl	465	13	)	)	-RRB-
cord-259603-bh198xgl	465	14	that	that	WDT
cord-259603-bh198xgl	465	15	essentially	essentially	RB
cord-259603-bh198xgl	465	16	inactivated	inactivate	VBD
cord-259603-bh198xgl	465	17	transcription	transcription	NN
cord-259603-bh198xgl	465	18	while	while	IN
cord-259603-bh198xgl	465	19	leaving	leave	VBG
cord-259603-bh198xgl	465	20	replication	replication	NN
cord-259603-bh198xgl	465	21	unaffected	unaffected	JJ
cord-259603-bh198xgl	465	22	was	be	VBD
cord-259603-bh198xgl	465	23	an	an	DT
cord-259603-bh198xgl	465	24	early	early	JJ
cord-259603-bh198xgl	465	25	indication	indication	NN
cord-259603-bh198xgl	465	26	for	for	IN
cord-259603-bh198xgl	465	27	the	the	DT
cord-259603-bh198xgl	465	28	involvement	involvement	NN
cord-259603-bh198xgl	465	29	of	of	IN
cord-259603-bh198xgl	465	30	the	the	DT
cord-259603-bh198xgl	465	31	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	465	32	helicase	helicase	NNP
cord-259603-bh198xgl	465	33	in	in	IN
cord-259603-bh198xgl	465	34	the	the	DT
cord-259603-bh198xgl	465	35	control	control	NN
cord-259603-bh198xgl	465	36	of	of	IN
cord-259603-bh198xgl	465	37	sg	sg	NNP
cord-259603-bh198xgl	465	38	mRNA	mRNA	NNP
cord-259603-bh198xgl	465	39	synthesis	synthesis	NNP
cord-259603-bh198xgl	465	40	(	(	-LRB-
cord-259603-bh198xgl	465	41	van	van	NNP
cord-259603-bh198xgl	465	42	Dinten	Dinten	NNP
cord-259603-bh198xgl	465	43	et	et	FW
cord-259603-bh198xgl	465	44	al	al	NNP
cord-259603-bh198xgl	465	45	.	.	NNP
cord-259603-bh198xgl	465	46	,	,	,
cord-259603-bh198xgl	465	47	1997	1997	CD
cord-259603-bh198xgl	465	48	)	)	-RRB-
cord-259603-bh198xgl	465	49	.	.	.
cord-259603-bh198xgl	466	1	Such	such	JJ
cord-259603-bh198xgl	466	2	control	control	NN
cord-259603-bh198xgl	466	3	functions	function	NNS
cord-259603-bh198xgl	466	4	could	could	MD
cord-259603-bh198xgl	466	5	also	also	RB
cord-259603-bh198xgl	466	6	be	be	VB
cord-259603-bh198xgl	466	7	related	relate	VBN
cord-259603-bh198xgl	466	8	to	to	IN
cord-259603-bh198xgl	466	9	the	the	DT
cord-259603-bh198xgl	466	10	recognition	recognition	NN
cord-259603-bh198xgl	466	11	of	of	IN
cord-259603-bh198xgl	466	12	TRSs	TRSs	NNP
cord-259603-bh198xgl	466	13	(	(	-LRB-
cord-259603-bh198xgl	466	14	Fig	Fig	NNP
cord-259603-bh198xgl	466	15	.	.	NNP
cord-259603-bh198xgl	466	16	1	1	CD
cord-259603-bh198xgl	466	17	)	)	-RRB-
cord-259603-bh198xgl	466	18	,	,	,
cord-259603-bh198xgl	466	19	the	the	DT
cord-259603-bh198xgl	466	20	frequency	frequency	NN
cord-259603-bh198xgl	466	21	with	with	IN
cord-259603-bh198xgl	466	22	which	which	WDT
cord-259603-bh198xgl	466	23	each	each	DT
cord-259603-bh198xgl	466	24	of	of	IN
cord-259603-bh198xgl	466	25	the	the	DT
cord-259603-bh198xgl	466	26	TRSs	trs	NNS
cord-259603-bh198xgl	466	27	is	be	VBZ
cord-259603-bh198xgl	466	28	used	use	VBN
cord-259603-bh198xgl	466	29	to	to	TO
cord-259603-bh198xgl	466	30	produce	produce	VB
cord-259603-bh198xgl	466	31	a	a	DT
cord-259603-bh198xgl	466	32	subgenome	subgenome	NN
cord-259603-bh198xgl	466	33	-	-	HYPH
cord-259603-bh198xgl	466	34	length	length	NN
cord-259603-bh198xgl	466	35	minus	minus	JJ
cord-259603-bh198xgl	466	36	strand	strand	NN
cord-259603-bh198xgl	466	37	,	,	,
cord-259603-bh198xgl	466	38	or	or	CC
cord-259603-bh198xgl	466	39	mechanistic	mechanistic	JJ
cord-259603-bh198xgl	466	40	aspects	aspect	NNS
cord-259603-bh198xgl	466	41	of	of	IN
cord-259603-bh198xgl	466	42	the	the	DT
cord-259603-bh198xgl	466	43	stalling	stalling	NN
cord-259603-bh198xgl	466	44	and	and	CC
cord-259603-bh198xgl	466	45	reinitiation	reinitiation	NN
cord-259603-bh198xgl	466	46	of	of	IN
cord-259603-bh198xgl	466	47	RNA	RNA	NNP
cord-259603-bh198xgl	466	48	synthesis	synthesis	NN
cord-259603-bh198xgl	466	49	or	or	CC
cord-259603-bh198xgl	466	50	the	the	DT
cord-259603-bh198xgl	466	51	transfer	transfer	NN
cord-259603-bh198xgl	466	52	of	of	IN
cord-259603-bh198xgl	466	53	the	the	DT
cord-259603-bh198xgl	466	54	nascent	nascent	JJ
cord-259603-bh198xgl	466	55	strand	strand	NN
cord-259603-bh198xgl	466	56	to	to	IN
cord-259603-bh198xgl	466	57	an	an	DT
cord-259603-bh198xgl	466	58	upstream	upstream	JJ
cord-259603-bh198xgl	466	59	position	position	NN
cord-259603-bh198xgl	466	60	on	on	IN
cord-259603-bh198xgl	466	61	the	the	DT
cord-259603-bh198xgl	466	62	template	template	NN
cord-259603-bh198xgl	466	63	(	(	-LRB-
cord-259603-bh198xgl	466	64	see	see	VB
cord-259603-bh198xgl	466	65	earlier	early	RBR
cord-259603-bh198xgl	466	66	)	)	-RRB-
cord-259603-bh198xgl	466	67	,	,	,
cord-259603-bh198xgl	466	68	which	which	WDT
cord-259603-bh198xgl	466	69	must	must	MD
cord-259603-bh198xgl	466	70	occur	occur	VB
cord-259603-bh198xgl	466	71	during	during	IN
cord-259603-bh198xgl	466	72	the	the	DT
cord-259603-bh198xgl	466	73	discontinuous	discontinuous	JJ
cord-259603-bh198xgl	466	74	step	step	NN
cord-259603-bh198xgl	466	75	in	in	IN
cord-259603-bh198xgl	466	76	sg	sg	NNP
cord-259603-bh198xgl	466	77	RNA	RNA	NNP
cord-259603-bh198xgl	466	78	synthesis	synthesis	NN
cord-259603-bh198xgl	467	1	(	(	-LRB-
cord-259603-bh198xgl	467	2	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	467	3	et	et	NNP
cord-259603-bh198xgl	467	4	al	al	NNP
cord-259603-bh198xgl	467	5	.	.	NNP
cord-259603-bh198xgl	467	6	,	,	,
cord-259603-bh198xgl	467	7	2015c	2015c	CD
cord-259603-bh198xgl	467	8	)	)	-RRB-
cord-259603-bh198xgl	467	9	.	.	.
cord-259603-bh198xgl	468	1	Recently	recently	RB
cord-259603-bh198xgl	468	2	,	,	,
cord-259603-bh198xgl	468	3	the	the	DT
cord-259603-bh198xgl	468	4	EAV	EAV	NNP
cord-259603-bh198xgl	468	5	nsp10	nsp10	NNP
cord-259603-bh198xgl	468	6	Ser-59	Ser-59	NNP
cord-259603-bh198xgl	468	7	!	!	.
cord-259603-bh198xgl	469	1	Pro	pro	JJ
cord-259603-bh198xgl	469	2	mutation	mutation	NN
cord-259603-bh198xgl	469	3	,	,	,
cord-259603-bh198xgl	469	4	which	which	WDT
cord-259603-bh198xgl	469	5	selectively	selectively	RB
cord-259603-bh198xgl	469	6	reduces	reduce	VBZ
cord-259603-bh198xgl	469	7	transcription	transcription	NN
cord-259603-bh198xgl	469	8	of	of	IN
cord-259603-bh198xgl	469	9	all	all	DT
cord-259603-bh198xgl	469	10	subgenomic	subgenomic	JJ
cord-259603-bh198xgl	469	11	mRNAs	mRNAs	NNPS
cord-259603-bh198xgl	469	12	to	to	IN
cord-259603-bh198xgl	469	13	below	below	IN
cord-259603-bh198xgl	469	14	1	1	CD
cord-259603-bh198xgl	469	15	%	%	NN
cord-259603-bh198xgl	469	16	of	of	IN
cord-259603-bh198xgl	469	17	their	-PRON-	PRP$
cord-259603-bh198xgl	469	18	normal	normal	JJ
cord-259603-bh198xgl	469	19	levels	level	NNS
cord-259603-bh198xgl	469	20	,	,	,
cord-259603-bh198xgl	469	21	was	be	VBD
cord-259603-bh198xgl	469	22	reanalyzed	reanalyze	VBN
cord-259603-bh198xgl	469	23	in	in	IN
cord-259603-bh198xgl	469	24	the	the	DT
cord-259603-bh198xgl	469	25	context	context	NN
cord-259603-bh198xgl	469	26	of	of	IN
cord-259603-bh198xgl	469	27	the	the	DT
cord-259603-bh198xgl	469	28	nsp10	nsp10	NNP
cord-259603-bh198xgl	469	29	crystal	crystal	NN
cord-259603-bh198xgl	469	30	structure	structure	NN
cord-259603-bh198xgl	469	31	.	.	.
cord-259603-bh198xgl	470	1	As	as	IN
cord-259603-bh198xgl	470	2	postulated	postulate	VBN
cord-259603-bh198xgl	470	3	when	when	WRB
cord-259603-bh198xgl	470	4	this	this	DT
cord-259603-bh198xgl	470	5	virus	virus	NN
cord-259603-bh198xgl	470	6	mutant	mutant	NN
cord-259603-bh198xgl	470	7	was	be	VBD
cord-259603-bh198xgl	470	8	first	first	RB
cord-259603-bh198xgl	470	9	described	describe	VBN
cord-259603-bh198xgl	470	10	,	,	,
cord-259603-bh198xgl	470	11	its	-PRON-	PRP$
cord-259603-bh198xgl	470	12	phenotype	phenotype	NN
cord-259603-bh198xgl	470	13	appears	appear	VBZ
cord-259603-bh198xgl	470	14	to	to	TO
cord-259603-bh198xgl	470	15	be	be	VB
cord-259603-bh198xgl	470	16	based	base	VBN
cord-259603-bh198xgl	470	17	on	on	IN
cord-259603-bh198xgl	470	18	the	the	DT
cord-259603-bh198xgl	470	19	special	special	JJ
cord-259603-bh198xgl	470	20	structural	structural	JJ
cord-259603-bh198xgl	470	21	properties	property	NNS
cord-259603-bh198xgl	470	22	of	of	IN
cord-259603-bh198xgl	470	23	the	the	DT
cord-259603-bh198xgl	470	24	Pro	pro	JJ
cord-259603-bh198xgl	470	25	residue	residue	NN
cord-259603-bh198xgl	470	26	in	in	IN
cord-259603-bh198xgl	470	27	combination	combination	NN
cord-259603-bh198xgl	470	28	with	with	IN
cord-259603-bh198xgl	470	29	the	the	DT
cord-259603-bh198xgl	470	30	position	position	NN
cord-259603-bh198xgl	470	31	of	of	IN
cord-259603-bh198xgl	470	32	residue	residue	NN
cord-259603-bh198xgl	470	33	59	59	CD
cord-259603-bh198xgl	470	34	in	in	IN
cord-259603-bh198xgl	470	35	a	a	DT
cord-259603-bh198xgl	470	36	"	"	``
cord-259603-bh198xgl	470	37	hinge	hinge	NN
cord-259603-bh198xgl	470	38	"	"	''
cord-259603-bh198xgl	470	39	region	region	NN
cord-259603-bh198xgl	470	40	that	that	WDT
cord-259603-bh198xgl	470	41	connects	connect	VBZ
cord-259603-bh198xgl	470	42	ZBD	ZBD	NNP
cord-259603-bh198xgl	470	43	to	to	IN
cord-259603-bh198xgl	470	44	the	the	DT
cord-259603-bh198xgl	470	45	rest	rest	NN
cord-259603-bh198xgl	470	46	of	of	IN
cord-259603-bh198xgl	470	47	the	the	DT
cord-259603-bh198xgl	470	48	protein	protein	NN
cord-259603-bh198xgl	471	1	(	(	-LRB-
cord-259603-bh198xgl	471	2	Deng	Deng	NNP
cord-259603-bh198xgl	471	3	et	et	FW
cord-259603-bh198xgl	471	4	al	al	NNP
cord-259603-bh198xgl	471	5	.	.	.
cord-259603-bh198xgl	472	1	,	,	,
cord-259603-bh198xgl	472	2	2014	2014	CD
cord-259603-bh198xgl	472	3	)	)	-RRB-
cord-259603-bh198xgl	472	4	.	.	.
cord-259603-bh198xgl	473	1	Although	although	IN
cord-259603-bh198xgl	473	2	residue	residue	NN
cord-259603-bh198xgl	473	3	59	59	CD
cord-259603-bh198xgl	473	4	,	,	,
cord-259603-bh198xgl	473	5	located	locate	VBN
cord-259603-bh198xgl	473	6	just	just	RB
cord-259603-bh198xgl	473	7	downstream	downstream	RB
cord-259603-bh198xgl	473	8	of	of	IN
cord-259603-bh198xgl	473	9	the	the	DT
cord-259603-bh198xgl	473	10	second	second	JJ
cord-259603-bh198xgl	473	11	zinc	zinc	NN
cord-259603-bh198xgl	473	12	-	-	HYPH
cord-259603-bh198xgl	473	13	binding	bind	VBG
cord-259603-bh198xgl	473	14	module	module	NN
cord-259603-bh198xgl	473	15	of	of	IN
cord-259603-bh198xgl	473	16	the	the	DT
cord-259603-bh198xgl	473	17	ZBD	ZBD	NNP
cord-259603-bh198xgl	473	18	,	,	,
cord-259603-bh198xgl	473	19	is	be	VBZ
cord-259603-bh198xgl	473	20	fairly	fairly	RB
cord-259603-bh198xgl	473	21	distant	distant	JJ
cord-259603-bh198xgl	473	22	from	from	IN
cord-259603-bh198xgl	473	23	the	the	DT
cord-259603-bh198xgl	473	24	RNA	RNA	NNP
cord-259603-bh198xgl	473	25	-	-	HYPH
cord-259603-bh198xgl	473	26	binding	bind	VBG
cord-259603-bh198xgl	473	27	surface	surface	NN
cord-259603-bh198xgl	473	28	,	,	,
cord-259603-bh198xgl	473	29	it	-PRON-	PRP
cord-259603-bh198xgl	473	30	resides	reside	VBZ
cord-259603-bh198xgl	473	31	in	in	IN
cord-259603-bh198xgl	473	32	a	a	DT
cord-259603-bh198xgl	473	33	region	region	NN
cord-259603-bh198xgl	473	34	that	that	WDT
cord-259603-bh198xgl	473	35	connects	connect	VBZ
cord-259603-bh198xgl	473	36	the	the	DT
cord-259603-bh198xgl	473	37	ZBD	ZBD	NNP
cord-259603-bh198xgl	473	38	treble	treble	JJ
cord-259603-bh198xgl	473	39	-	-	HYPH
cord-259603-bh198xgl	473	40	clef	clef	NN
cord-259603-bh198xgl	473	41	zinc	zinc	NN
cord-259603-bh198xgl	473	42	finger	finger	NN
cord-259603-bh198xgl	473	43	to	to	IN
cord-259603-bh198xgl	473	44	a	a	DT
cord-259603-bh198xgl	473	45	helix	helix	NN
cord-259603-bh198xgl	473	46	that	that	WDT
cord-259603-bh198xgl	473	47	interacts	interact	VBZ
cord-259603-bh198xgl	473	48	with	with	IN
cord-259603-bh198xgl	473	49	domains	domain	NNS
cord-259603-bh198xgl	473	50	1A	1a	CD
cord-259603-bh198xgl	473	51	and	and	CC
cord-259603-bh198xgl	473	52	1B	1b	CD
cord-259603-bh198xgl	473	53	and	and	CC
cord-259603-bh198xgl	473	54	with	with	IN
cord-259603-bh198xgl	473	55	the	the	DT
cord-259603-bh198xgl	473	56	nucleic	nucleic	JJ
cord-259603-bh198xgl	473	57	acid	acid	NN
cord-259603-bh198xgl	473	58	.	.	.
cord-259603-bh198xgl	474	1	Thus	thus	RB
cord-259603-bh198xgl	474	2	,	,	,
cord-259603-bh198xgl	474	3	specific	specific	JJ
cord-259603-bh198xgl	474	4	mutations	mutation	NNS
cord-259603-bh198xgl	474	5	affecting	affect	VBG
cord-259603-bh198xgl	474	6	the	the	DT
cord-259603-bh198xgl	474	7	flexibility	flexibility	NN
cord-259603-bh198xgl	474	8	of	of	IN
cord-259603-bh198xgl	474	9	this	this	DT
cord-259603-bh198xgl	474	10	hinge	hinge	NN
cord-259603-bh198xgl	474	11	region	region	NN
cord-259603-bh198xgl	474	12	may	may	MD
cord-259603-bh198xgl	474	13	drastically	drastically	RB
cord-259603-bh198xgl	474	14	influence	influence	VB
cord-259603-bh198xgl	474	15	the	the	DT
cord-259603-bh198xgl	474	16	long	long	JJ
cord-259603-bh198xgl	474	17	-	-	HYPH
cord-259603-bh198xgl	474	18	distance	distance	NN
cord-259603-bh198xgl	474	19	signaling	signaling	NN
cord-259603-bh198xgl	474	20	within	within	IN
cord-259603-bh198xgl	474	21	nsp10	nsp10	NNPS
cord-259603-bh198xgl	474	22	,	,	,
cord-259603-bh198xgl	474	23	apparently	apparently	RB
cord-259603-bh198xgl	474	24	preventing	prevent	VBG
cord-259603-bh198xgl	474	25	the	the	DT
cord-259603-bh198xgl	474	26	RNAsynthesizing	rnasynthesize	VBG
cord-259603-bh198xgl	474	27	machinery	machinery	NN
cord-259603-bh198xgl	474	28	to	to	TO
cord-259603-bh198xgl	474	29	work	work	VB
cord-259603-bh198xgl	474	30	in	in	IN
cord-259603-bh198xgl	474	31	"	"	``
cord-259603-bh198xgl	474	32	transcription	transcription	NN
cord-259603-bh198xgl	474	33	mode	mode	NN
cord-259603-bh198xgl	474	34	"	"	''
cord-259603-bh198xgl	474	35	and	and	CC
cord-259603-bh198xgl	474	36	dedicating	dedicate	VBG
cord-259603-bh198xgl	474	37	it	-PRON-	PRP
cord-259603-bh198xgl	474	38	exclusively	exclusively	RB
cord-259603-bh198xgl	474	39	to	to	IN
cord-259603-bh198xgl	474	40	full	full	JJ
cord-259603-bh198xgl	474	41	-	-	HYPH
cord-259603-bh198xgl	474	42	length	length	NN
cord-259603-bh198xgl	474	43	minus	minus	JJ
cord-259603-bh198xgl	474	44	-	-	HYPH
cord-259603-bh198xgl	474	45	strand	strand	NN
cord-259603-bh198xgl	474	46	RNA	RNA	NNP
cord-259603-bh198xgl	474	47	synthesis	synthesis	NN
cord-259603-bh198xgl	474	48	and	and	CC
cord-259603-bh198xgl	474	49	genome	genome	NN
cord-259603-bh198xgl	474	50	amplification	amplification	NN
cord-259603-bh198xgl	474	51	.	.	.
cord-259603-bh198xgl	475	1	Since	since	IN
cord-259603-bh198xgl	475	2	this	this	DT
cord-259603-bh198xgl	475	3	kind	kind	NN
cord-259603-bh198xgl	475	4	of	of	IN
cord-259603-bh198xgl	475	5	mutations	mutation	NNS
cord-259603-bh198xgl	475	6	barely	barely	RB
cord-259603-bh198xgl	475	7	affected	affect	VBD
cord-259603-bh198xgl	475	8	nsp10s	nsp10s	NNPS
cord-259603-bh198xgl	475	9	in	in	IN
cord-259603-bh198xgl	475	10	vitro	vitro	FW
cord-259603-bh198xgl	475	11	NTPase	NTPase	NNP
cord-259603-bh198xgl	475	12	and	and	CC
cord-259603-bh198xgl	475	13	helicase	helicase	NN
cord-259603-bh198xgl	475	14	activities	activity	NNS
cord-259603-bh198xgl	476	1	(	(	-LRB-
cord-259603-bh198xgl	476	2	Seybert	Seybert	NNP
cord-259603-bh198xgl	476	3	et	et	NNP
cord-259603-bh198xgl	476	4	al	al	NNP
cord-259603-bh198xgl	476	5	.	.	NNP
cord-259603-bh198xgl	476	6	,	,	,
cord-259603-bh198xgl	476	7	2005	2005	CD
cord-259603-bh198xgl	476	8	)	)	-RRB-
cord-259603-bh198xgl	476	9	,	,	,
cord-259603-bh198xgl	476	10	it	-PRON-	PRP
cord-259603-bh198xgl	476	11	may	may	MD
cord-259603-bh198xgl	476	12	well	well	RB
cord-259603-bh198xgl	476	13	be	be	VB
cord-259603-bh198xgl	476	14	that	that	IN
cord-259603-bh198xgl	476	15	changed	change	VBN
cord-259603-bh198xgl	476	16	interactions	interaction	NNS
cord-259603-bh198xgl	476	17	with	with	IN
cord-259603-bh198xgl	476	18	specific	specific	JJ
cord-259603-bh198xgl	476	19	protein	protein	NN
cord-259603-bh198xgl	476	20	partners	partner	NNS
cord-259603-bh198xgl	476	21	will	will	MD
cord-259603-bh198xgl	476	22	turn	turn	VB
cord-259603-bh198xgl	476	23	out	out	RP
cord-259603-bh198xgl	476	24	to	to	TO
cord-259603-bh198xgl	476	25	be	be	VB
cord-259603-bh198xgl	476	26	the	the	DT
cord-259603-bh198xgl	476	27	key	key	NN
cord-259603-bh198xgl	476	28	to	to	IN
cord-259603-bh198xgl	476	29	explaining	explain	VBG
cord-259603-bh198xgl	476	30	the	the	DT
cord-259603-bh198xgl	476	31	transcription	transcription	NN
cord-259603-bh198xgl	476	32	-	-	HYPH
cord-259603-bh198xgl	476	33	negative	negative	JJ
cord-259603-bh198xgl	476	34	phenotype	phenotype	NN
cord-259603-bh198xgl	476	35	of	of	IN
cord-259603-bh198xgl	476	36	the	the	DT
cord-259603-bh198xgl	476	37	corresponding	corresponding	JJ
cord-259603-bh198xgl	476	38	virus	virus	NN
cord-259603-bh198xgl	476	39	mutants	mutant	NNS
cord-259603-bh198xgl	476	40	(	(	-LRB-
cord-259603-bh198xgl	476	41	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	476	42	et	et	NNP
cord-259603-bh198xgl	476	43	al	al	NNP
cord-259603-bh198xgl	476	44	.	.	NNP
cord-259603-bh198xgl	476	45	,	,	,
cord-259603-bh198xgl	476	46	2015c	2015c	CD
cord-259603-bh198xgl	476	47	)	)	-RRB-
cord-259603-bh198xgl	476	48	.	.	.
cord-259603-bh198xgl	477	1	For	for	IN
cord-259603-bh198xgl	477	2	the	the	DT
cord-259603-bh198xgl	477	3	coronavirus	coronavirus	NN
cord-259603-bh198xgl	477	4	IBV	IBV	NNP
cord-259603-bh198xgl	477	5	,	,	,
cord-259603-bh198xgl	477	6	a	a	DT
cord-259603-bh198xgl	477	7	point	point	NN
cord-259603-bh198xgl	477	8	mutation	mutation	NN
cord-259603-bh198xgl	477	9	in	in	IN
cord-259603-bh198xgl	477	10	a	a	DT
cord-259603-bh198xgl	477	11	somewhat	somewhat	RB
cord-259603-bh198xgl	477	12	comparable	comparable	JJ
cord-259603-bh198xgl	477	13	position	position	NN
cord-259603-bh198xgl	477	14	of	of	IN
cord-259603-bh198xgl	477	15	nsp13	nsp13	ADD
cord-259603-bh198xgl	477	16	(	(	-LRB-
cord-259603-bh198xgl	477	17	Arg-132	arg-132	NN
cord-259603-bh198xgl	477	18	!	!	.
cord-259603-bh198xgl	478	1	Pro	pro	JJ
cord-259603-bh198xgl	478	2	;	;	:
cord-259603-bh198xgl	478	3	just	just	RB
cord-259603-bh198xgl	478	4	downstream	downstream	RB
cord-259603-bh198xgl	478	5	of	of	IN
cord-259603-bh198xgl	478	6	ZBD	ZBD	NNP
cord-259603-bh198xgl	478	7	)	)	-RRB-
cord-259603-bh198xgl	478	8	was	be	VBD
cord-259603-bh198xgl	478	9	reported	report	VBN
cord-259603-bh198xgl	478	10	to	to	TO
cord-259603-bh198xgl	478	11	cause	cause	VB
cord-259603-bh198xgl	478	12	a	a	DT
cord-259603-bh198xgl	478	13	similar	similar	JJ
cord-259603-bh198xgl	478	14	block	block	NN
cord-259603-bh198xgl	478	15	of	of	IN
cord-259603-bh198xgl	478	16	sg	sg	NNP
cord-259603-bh198xgl	478	17	mRNA	mRNA	NNP
cord-259603-bh198xgl	478	18	synthesis	synthesis	NN
cord-259603-bh198xgl	478	19	(	(	-LRB-
cord-259603-bh198xgl	478	20	Fang	Fang	NNP
cord-259603-bh198xgl	478	21	et	et	FW
cord-259603-bh198xgl	478	22	al	al	NNP
cord-259603-bh198xgl	478	23	.	.	NNP
cord-259603-bh198xgl	478	24	,	,	,
cord-259603-bh198xgl	478	25	2007	2007	CD
cord-259603-bh198xgl	478	26	)	)	-RRB-
cord-259603-bh198xgl	479	1	but	but	CC
cord-259603-bh198xgl	479	2	,	,	,
cord-259603-bh198xgl	479	3	thus	thus	RB
cord-259603-bh198xgl	479	4	far	far	RB
cord-259603-bh198xgl	479	5	,	,	,
cord-259603-bh198xgl	479	6	this	this	DT
cord-259603-bh198xgl	479	7	observation	observation	NN
cord-259603-bh198xgl	479	8	has	have	VBZ
cord-259603-bh198xgl	479	9	not	not	RB
cord-259603-bh198xgl	479	10	been	be	VBN
cord-259603-bh198xgl	479	11	followed	follow	VBN
cord-259603-bh198xgl	479	12	up	up	RP
cord-259603-bh198xgl	479	13	in	in	IN
cord-259603-bh198xgl	479	14	more	more	JJR
cord-259603-bh198xgl	479	15	detail	detail	NN
cord-259603-bh198xgl	479	16	for	for	IN
cord-259603-bh198xgl	479	17	IBV	IBV	NNP
cord-259603-bh198xgl	479	18	or	or	CC
cord-259603-bh198xgl	479	19	confirmed	confirm	VBN
cord-259603-bh198xgl	479	20	for	for	IN
cord-259603-bh198xgl	479	21	nsp13	nsp13	ADD
cord-259603-bh198xgl	479	22	of	of	IN
cord-259603-bh198xgl	479	23	another	another	DT
cord-259603-bh198xgl	480	1	CoV.	CoV.	NNP
cord-259603-bh198xgl	481	1	In	in	IN
cord-259603-bh198xgl	481	2	addition	addition	NN
cord-259603-bh198xgl	481	3	to	to	IN
cord-259603-bh198xgl	481	4	its	-PRON-	PRP$
cord-259603-bh198xgl	481	5	role	role	NN
cord-259603-bh198xgl	481	6	in	in	IN
cord-259603-bh198xgl	481	7	RNA	RNA	NNP
cord-259603-bh198xgl	481	8	synthesis	synthesis	NN
cord-259603-bh198xgl	481	9	,	,	,
cord-259603-bh198xgl	481	10	the	the	DT
cord-259603-bh198xgl	481	11	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	481	12	helicase	helicase	NNP
cord-259603-bh198xgl	481	13	is	be	VBZ
cord-259603-bh198xgl	481	14	also	also	RB
cord-259603-bh198xgl	481	15	assumed	assume	VBN
cord-259603-bh198xgl	481	16	to	to	TO
cord-259603-bh198xgl	481	17	be	be	VB
cord-259603-bh198xgl	481	18	involved	involve	VBN
cord-259603-bh198xgl	481	19	in	in	IN
cord-259603-bh198xgl	481	20	the	the	DT
cord-259603-bh198xgl	481	21	capping	cap	VBG
cord-259603-bh198xgl	481	22	pathway	pathway	NN
cord-259603-bh198xgl	481	23	of	of	IN
cord-259603-bh198xgl	481	24	viral	viral	JJ
cord-259603-bh198xgl	481	25	mRNAs	mRNAs	NNPS
cord-259603-bh198xgl	481	26	by	by	IN
cord-259603-bh198xgl	481	27	exhibiting	exhibit	VBG
cord-259603-bh198xgl	481	28	an	an	DT
cord-259603-bh198xgl	481	29	RNA	RNA	NNP
cord-259603-bh198xgl	481	30	5	5	CD
cord-259603-bh198xgl	481	31	0	0	CD
cord-259603-bh198xgl	482	1	-triphosphatase	-triphosphatase	:
cord-259603-bh198xgl	482	2	(	(	-LRB-
cord-259603-bh198xgl	482	3	RTPase	RTPase	NFP
cord-259603-bh198xgl	482	4	)	)	-RRB-
cord-259603-bh198xgl	482	5	activity	activity	NN
cord-259603-bh198xgl	482	6	that	that	WDT
cord-259603-bh198xgl	482	7	can	can	MD
cord-259603-bh198xgl	482	8	remove	remove	VB
cord-259603-bh198xgl	482	9	the	the	DT
cord-259603-bh198xgl	482	10	5	5	CD
cord-259603-bh198xgl	482	11	0	0	CD
cord-259603-bh198xgl	482	12	-terminal	-terminal	NN
cord-259603-bh198xgl	482	13	triphosphate	triphosphate	NN
cord-259603-bh198xgl	482	14	from	from	IN
cord-259603-bh198xgl	482	15	the	the	DT
cord-259603-bh198xgl	482	16	RNA	RNA	NNP
cord-259603-bh198xgl	482	17	substrate	substrate	NN
cord-259603-bh198xgl	482	18	.	.	.
cord-259603-bh198xgl	483	1	For	for	IN
cord-259603-bh198xgl	483	2	SARS	SARS	NNP
cord-259603-bh198xgl	483	3	-	-	HYPH
cord-259603-bh198xgl	483	4	CoV	CoV	NNP
cord-259603-bh198xgl	483	5	and	and	CC
cord-259603-bh198xgl	483	6	HCoV-229E	HCoV-229E	NNP
cord-259603-bh198xgl	483	7	nsp13	nsp13	ADD
cord-259603-bh198xgl	483	8	,	,	,
cord-259603-bh198xgl	483	9	this	this	DT
cord-259603-bh198xgl	483	10	first	first	JJ
cord-259603-bh198xgl	483	11	step	step	NN
cord-259603-bh198xgl	483	12	in	in	IN
cord-259603-bh198xgl	483	13	viral	viral	JJ
cord-259603-bh198xgl	483	14	cap	cap	NN
cord-259603-bh198xgl	483	15	synthesis	synthesis	NN
cord-259603-bh198xgl	483	16	was	be	VBD
cord-259603-bh198xgl	483	17	shown	show	VBN
cord-259603-bh198xgl	483	18	to	to	TO
cord-259603-bh198xgl	483	19	rely	rely	VB
cord-259603-bh198xgl	483	20	on	on	IN
cord-259603-bh198xgl	483	21	the	the	DT
cord-259603-bh198xgl	483	22	same	same	JJ
cord-259603-bh198xgl	483	23	NTPase	NTPase	NNP
cord-259603-bh198xgl	483	24	active	active	JJ
cord-259603-bh198xgl	483	25	site	site	NN
cord-259603-bh198xgl	483	26	that	that	WDT
cord-259603-bh198xgl	483	27	provides	provide	VBZ
cord-259603-bh198xgl	483	28	the	the	DT
cord-259603-bh198xgl	483	29	energy	energy	NN
cord-259603-bh198xgl	483	30	for	for	IN
cord-259603-bh198xgl	483	31	the	the	DT
cord-259603-bh198xgl	483	32	protein	protein	NN
cord-259603-bh198xgl	483	33	's	's	POS
cord-259603-bh198xgl	483	34	helicase	helicase	NN
cord-259603-bh198xgl	483	35	activity	activity	NN
cord-259603-bh198xgl	483	36	(	(	-LRB-
cord-259603-bh198xgl	483	37	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	483	38	and	and	CC
cord-259603-bh198xgl	483	39	Ziebuhr	Ziebuhr	NNP
cord-259603-bh198xgl	483	40	,	,	,
cord-259603-bh198xgl	483	41	2004	2004	CD
cord-259603-bh198xgl	483	42	;	;	:
cord-259603-bh198xgl	483	43	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	483	44	et	et	NNP
cord-259603-bh198xgl	483	45	al	al	NNP
cord-259603-bh198xgl	483	46	.	.	NNP
cord-259603-bh198xgl	483	47	,	,	,
cord-259603-bh198xgl	483	48	2004b	2004b	CD
cord-259603-bh198xgl	483	49	)	)	-RRB-
cord-259603-bh198xgl	483	50	.	.	.
cord-259603-bh198xgl	484	1	The	the	DT
cord-259603-bh198xgl	484	2	CoV	cov	NN
cord-259603-bh198xgl	484	3	capping	cap	VBG
cord-259603-bh198xgl	484	4	pathway	pathway	NN
cord-259603-bh198xgl	484	5	is	be	VBZ
cord-259603-bh198xgl	484	6	discussed	discuss	VBN
cord-259603-bh198xgl	484	7	in	in	IN
cord-259603-bh198xgl	484	8	Section	section	NN
cord-259603-bh198xgl	484	9	5	5	CD
cord-259603-bh198xgl	484	10	of	of	IN
cord-259603-bh198xgl	484	11	this	this	DT
cord-259603-bh198xgl	484	12	review	review	NN
cord-259603-bh198xgl	484	13	.	.	.
cord-259603-bh198xgl	485	1	Finally	finally	RB
cord-259603-bh198xgl	485	2	,	,	,
cord-259603-bh198xgl	485	3	the	the	DT
cord-259603-bh198xgl	485	4	remarkable	remarkable	JJ
cord-259603-bh198xgl	485	5	similarities	similarity	NNS
cord-259603-bh198xgl	485	6	between	between	IN
cord-259603-bh198xgl	485	7	EAV	EAV	NNP
cord-259603-bh198xgl	485	8	nsp10	nsp10	NNPS
cord-259603-bh198xgl	485	9	and	and	CC
cord-259603-bh198xgl	485	10	the	the	DT
cord-259603-bh198xgl	485	11	cellular	cellular	JJ
cord-259603-bh198xgl	485	12	helicase	helicase	NN
cord-259603-bh198xgl	485	13	Upf1	Upf1	NNP
cord-259603-bh198xgl	485	14	(	(	-LRB-
cord-259603-bh198xgl	485	15	Deng	Deng	NNP
cord-259603-bh198xgl	485	16	et	et	FW
cord-259603-bh198xgl	485	17	al	al	NNP
cord-259603-bh198xgl	485	18	.	.	NNP
cord-259603-bh198xgl	485	19	,	,	,
cord-259603-bh198xgl	485	20	2014	2014	CD
cord-259603-bh198xgl	485	21	)	)	-RRB-
cord-259603-bh198xgl	485	22	have	have	VBP
cord-259603-bh198xgl	485	23	given	give	VBN
cord-259603-bh198xgl	485	24	rise	rise	NN
cord-259603-bh198xgl	485	25	to	to	IN
cord-259603-bh198xgl	485	26	the	the	DT
cord-259603-bh198xgl	485	27	intriguing	intriguing	JJ
cord-259603-bh198xgl	485	28	but	but	CC
cord-259603-bh198xgl	485	29	still	still	RB
cord-259603-bh198xgl	485	30	speculative	speculative	JJ
cord-259603-bh198xgl	485	31	hypothesis	hypothesis	NN
cord-259603-bh198xgl	485	32	that	that	IN
cord-259603-bh198xgl	485	33	the	the	DT
cord-259603-bh198xgl	485	34	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	485	35	helicase	helicase	NNP
cord-259603-bh198xgl	485	36	may	may	MD
cord-259603-bh198xgl	485	37	be	be	VB
cord-259603-bh198xgl	485	38	involved	involve	VBN
cord-259603-bh198xgl	485	39	in	in	IN
cord-259603-bh198xgl	485	40	the	the	DT
cord-259603-bh198xgl	485	41	posttranscriptional	posttranscriptional	JJ
cord-259603-bh198xgl	485	42	quality	quality	NN
cord-259603-bh198xgl	485	43	control	control	NN
cord-259603-bh198xgl	485	44	of	of	IN
cord-259603-bh198xgl	485	45	viral	viral	JJ
cord-259603-bh198xgl	485	46	RNA	RNA	NNP
cord-259603-bh198xgl	485	47	.	.	.
cord-259603-bh198xgl	486	1	Common	common	JJ
cord-259603-bh198xgl	486	2	features	feature	NNS
cord-259603-bh198xgl	486	3	of	of	IN
cord-259603-bh198xgl	486	4	the	the	DT
cord-259603-bh198xgl	486	5	two	two	CD
cord-259603-bh198xgl	486	6	helicases	helicase	NNS
cord-259603-bh198xgl	486	7	include	include	VBP
cord-259603-bh198xgl	486	8	their	-PRON-	PRP$
cord-259603-bh198xgl	486	9	5	5	CD
cord-259603-bh198xgl	486	10	0	0	CD
cord-259603-bh198xgl	486	11	-to-3	-to-3	CD
cord-259603-bh198xgl	486	12	0	0	CD
cord-259603-bh198xgl	486	13	polarity	polarity	NN
cord-259603-bh198xgl	486	14	of	of	IN
cord-259603-bh198xgl	486	15	unwinding	unwind	VBG
cord-259603-bh198xgl	486	16	,	,	,
cord-259603-bh198xgl	486	17	their	-PRON-	PRP$
cord-259603-bh198xgl	486	18	lack	lack	NN
cord-259603-bh198xgl	486	19	of	of	IN
cord-259603-bh198xgl	486	20	substrate	substrate	NN
cord-259603-bh198xgl	486	21	specificity	specificity	NN
cord-259603-bh198xgl	486	22	and	and	CC
cord-259603-bh198xgl	486	23	striking	strike	VBG
cord-259603-bh198xgl	486	24	similarities	similarity	NNS
cord-259603-bh198xgl	486	25	in	in	IN
cord-259603-bh198xgl	486	26	terms	term	NNS
cord-259603-bh198xgl	486	27	of	of	IN
cord-259603-bh198xgl	486	28	domain	domain	NN
cord-259603-bh198xgl	486	29	organization	organization	NN
cord-259603-bh198xgl	486	30	and	and	CC
cord-259603-bh198xgl	486	31	fold	fold	VB
cord-259603-bh198xgl	486	32	(	(	-LRB-
cord-259603-bh198xgl	486	33	Fig	fig	NN
cord-259603-bh198xgl	486	34	.	.	.
cord-259603-bh198xgl	486	35	4	4	LS
cord-259603-bh198xgl	486	36	)	)	-RRB-
cord-259603-bh198xgl	486	37	(	(	-LRB-
cord-259603-bh198xgl	486	38	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	486	39	et	et	NNP
cord-259603-bh198xgl	486	40	al	al	NNP
cord-259603-bh198xgl	486	41	.	.	NNP
cord-259603-bh198xgl	486	42	,	,	,
cord-259603-bh198xgl	486	43	2015c	2015c	CD
cord-259603-bh198xgl	486	44	)	)	-RRB-
cord-259603-bh198xgl	486	45	.	.	.
cord-259603-bh198xgl	487	1	Using	use	VBG
cord-259603-bh198xgl	487	2	several	several	JJ
cord-259603-bh198xgl	487	3	pathways	pathway	NNS
cord-259603-bh198xgl	487	4	,	,	,
cord-259603-bh198xgl	487	5	including	include	VBG
cord-259603-bh198xgl	487	6	nonsense	nonsense	NN
cord-259603-bh198xgl	487	7	-	-	HYPH
cord-259603-bh198xgl	487	8	mediated	mediate	VBN
cord-259603-bh198xgl	487	9	mRNA	mrna	NN
cord-259603-bh198xgl	487	10	decay	decay	NN
cord-259603-bh198xgl	487	11	,	,	,
cord-259603-bh198xgl	487	12	Upf1	Upf1	NNP
cord-259603-bh198xgl	487	13	mediates	mediate	VBZ
cord-259603-bh198xgl	487	14	RNA	RNA	NNP
cord-259603-bh198xgl	487	15	quality	quality	NN
cord-259603-bh198xgl	487	16	control	control	NN
cord-259603-bh198xgl	487	17	in	in	IN
cord-259603-bh198xgl	487	18	eukaryotic	eukaryotic	JJ
cord-259603-bh198xgl	487	19	cells	cell	NNS
cord-259603-bh198xgl	487	20	(	(	-LRB-
cord-259603-bh198xgl	487	21	Cheng	Cheng	NNP
cord-259603-bh198xgl	487	22	et	et	NNP
cord-259603-bh198xgl	487	23	al	al	NNP
cord-259603-bh198xgl	487	24	.	.	NNP
cord-259603-bh198xgl	487	25	,	,	,
cord-259603-bh198xgl	487	26	2007	2007	CD
cord-259603-bh198xgl	487	27	;	;	.
cord-259603-bh198xgl	488	1	Clerici	Clerici	NNP
cord-259603-bh198xgl	488	2	et	et	NNP
cord-259603-bh198xgl	488	3	al	al	NNP
cord-259603-bh198xgl	488	4	.	.	NNP
cord-259603-bh198xgl	488	5	,	,	,
cord-259603-bh198xgl	488	6	2009	2009	CD
cord-259603-bh198xgl	488	7	)	)	-RRB-
cord-259603-bh198xgl	488	8	,	,	,
cord-259603-bh198xgl	488	9	while	while	IN
cord-259603-bh198xgl	488	10	its	-PRON-	PRP$
cord-259603-bh198xgl	488	11	activity	activity	NN
cord-259603-bh198xgl	488	12	can	can	MD
cord-259603-bh198xgl	488	13	be	be	VB
cord-259603-bh198xgl	488	14	modulated	modulate	VBN
cord-259603-bh198xgl	488	15	through	through	IN
cord-259603-bh198xgl	488	16	interactions	interaction	NNS
cord-259603-bh198xgl	488	17	of	of	IN
cord-259603-bh198xgl	488	18	its	-PRON-	PRP$
cord-259603-bh198xgl	488	19	N	n	CD
cord-259603-bh198xgl	488	20	-	-	HYPH
cord-259603-bh198xgl	488	21	terminal	terminal	NN
cord-259603-bh198xgl	488	22	ZBD	ZBD	NNP
cord-259603-bh198xgl	488	23	.	.	.
cord-259603-bh198xgl	489	1	It	-PRON-	PRP
cord-259603-bh198xgl	489	2	was	be	VBD
cord-259603-bh198xgl	489	3	postulated	postulate	VBN
cord-259603-bh198xgl	489	4	that	that	IN
cord-259603-bh198xgl	489	5	a	a	DT
cord-259603-bh198xgl	489	6	similar	similar	JJ
cord-259603-bh198xgl	489	7	function	function	NN
cord-259603-bh198xgl	489	8	in	in	IN
cord-259603-bh198xgl	489	9	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	489	10	replication	replication	NN
cord-259603-bh198xgl	489	11	,	,	,
cord-259603-bh198xgl	489	12	e.g.	e.g.	RB
cord-259603-bh198xgl	489	13	,	,	,
cord-259603-bh198xgl	489	14	detection	detection	NN
cord-259603-bh198xgl	489	15	and	and	CC
cord-259603-bh198xgl	489	16	elimination	elimination	NN
cord-259603-bh198xgl	489	17	of	of	IN
cord-259603-bh198xgl	489	18	defective	defective	JJ
cord-259603-bh198xgl	489	19	viral	viral	NN
cord-259603-bh198xgl	489	20	mRNAs	mRNAs	.
cord-259603-bh198xgl	489	21	(	(	-LRB-
cord-259603-bh198xgl	489	22	including	include	VBG
cord-259603-bh198xgl	489	23	the	the	DT
cord-259603-bh198xgl	489	24	genome	genome	NN
cord-259603-bh198xgl	489	25	)	)	-RRB-
cord-259603-bh198xgl	489	26	,	,	,
cord-259603-bh198xgl	489	27	could	could	MD
cord-259603-bh198xgl	489	28	explain	explain	VB
cord-259603-bh198xgl	489	29	the	the	DT
cord-259603-bh198xgl	489	30	conservation	conservation	NN
cord-259603-bh198xgl	489	31	of	of	IN
cord-259603-bh198xgl	489	32	the	the	DT
cord-259603-bh198xgl	489	33	unique	unique	JJ
cord-259603-bh198xgl	489	34	ZBD	ZBD	NNP
cord-259603-bh198xgl	489	35	across	across	IN
cord-259603-bh198xgl	489	36	the	the	DT
cord-259603-bh198xgl	489	37	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	489	38	order	order	NN
cord-259603-bh198xgl	489	39	,	,	,
cord-259603-bh198xgl	489	40	which	which	WDT
cord-259603-bh198xgl	489	41	stands	stand	VBZ
cord-259603-bh198xgl	489	42	out	out	RP
cord-259603-bh198xgl	489	43	for	for	IN
cord-259603-bh198xgl	489	44	containing	contain	VBG
cord-259603-bh198xgl	489	45	members	member	NNS
cord-259603-bh198xgl	489	46	with	with	IN
cord-259603-bh198xgl	489	47	very	very	RB
cord-259603-bh198xgl	489	48	large	large	JJ
cord-259603-bh198xgl	489	49	+	+	CC
cord-259603-bh198xgl	489	50	RNA	rna	NN
cord-259603-bh198xgl	489	51	genomes	genome	NNS
cord-259603-bh198xgl	489	52	.	.	.
cord-259603-bh198xgl	490	1	Such	such	JJ
cord-259603-bh198xgl	490	2	a	a	DT
cord-259603-bh198xgl	490	3	function	function	NN
cord-259603-bh198xgl	490	4	would	would	MD
cord-259603-bh198xgl	490	5	prevent	prevent	VB
cord-259603-bh198xgl	490	6	the	the	DT
cord-259603-bh198xgl	490	7	synthesis	synthesis	NN
cord-259603-bh198xgl	490	8	of	of	IN
cord-259603-bh198xgl	490	9	defective	defective	JJ
cord-259603-bh198xgl	490	10	viral	viral	JJ
cord-259603-bh198xgl	490	11	polypeptides	polypeptide	NNS
cord-259603-bh198xgl	490	12	,	,	,
cord-259603-bh198xgl	490	13	which	which	WDT
cord-259603-bh198xgl	490	14	might	may	MD
cord-259603-bh198xgl	490	15	interfere	interfere	VB
cord-259603-bh198xgl	490	16	with	with	IN
cord-259603-bh198xgl	490	17	the	the	DT
cord-259603-bh198xgl	490	18	proper	proper	JJ
cord-259603-bh198xgl	490	19	functioning	functioning	NN
cord-259603-bh198xgl	490	20	of	of	IN
cord-259603-bh198xgl	490	21	full	full	JJ
cord-259603-bh198xgl	490	22	-	-	HYPH
cord-259603-bh198xgl	490	23	length	length	NN
cord-259603-bh198xgl	490	24	viral	viral	JJ
cord-259603-bh198xgl	490	25	proteins	protein	NNS
cord-259603-bh198xgl	490	26	.	.	.
cord-259603-bh198xgl	491	1	In	in	IN
cord-259603-bh198xgl	491	2	this	this	DT
cord-259603-bh198xgl	491	3	manner	manner	NN
cord-259603-bh198xgl	491	4	,	,	,
cord-259603-bh198xgl	491	5	not	not	RB
cord-259603-bh198xgl	491	6	unlike	unlike	IN
cord-259603-bh198xgl	491	7	the	the	DT
cord-259603-bh198xgl	491	8	nsp14-ExoN	nsp14-ExoN	NNP
cord-259603-bh198xgl	491	9	domain	domain	NN
cord-259603-bh198xgl	491	10	(	(	-LRB-
cord-259603-bh198xgl	491	11	see	see	VB
cord-259603-bh198xgl	491	12	earlier	early	RBR
cord-259603-bh198xgl	491	13	)	)	-RRB-
cord-259603-bh198xgl	491	14	,	,	,
cord-259603-bh198xgl	491	15	the	the	DT
cord-259603-bh198xgl	491	16	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	491	17	helicase	helicase	NNP
cord-259603-bh198xgl	491	18	may	may	MD
cord-259603-bh198xgl	491	19	have	have	VB
cord-259603-bh198xgl	491	20	contributed	contribute	VBN
cord-259603-bh198xgl	491	21	to	to	TO
cord-259603-bh198xgl	491	22	genome	genome	VB
cord-259603-bh198xgl	491	23	expansion	expansion	NN
cord-259603-bh198xgl	491	24	by	by	IN
cord-259603-bh198xgl	491	25	providing	provide	VBG
cord-259603-bh198xgl	491	26	a	a	DT
cord-259603-bh198xgl	491	27	form	form	NN
cord-259603-bh198xgl	491	28	of	of	IN
cord-259603-bh198xgl	491	29	compensation	compensation	NN
cord-259603-bh198xgl	491	30	for	for	IN
cord-259603-bh198xgl	491	31	the	the	DT
cord-259603-bh198xgl	491	32	relatively	relatively	RB
cord-259603-bh198xgl	491	33	poor	poor	JJ
cord-259603-bh198xgl	491	34	fidelity	fidelity	NN
cord-259603-bh198xgl	491	35	of	of	IN
cord-259603-bh198xgl	491	36	genome	genome	NN
cord-259603-bh198xgl	491	37	replication	replication	NN
cord-259603-bh198xgl	491	38	by	by	IN
cord-259603-bh198xgl	491	39	the	the	DT
cord-259603-bh198xgl	491	40	nidoviral	nidoviral	NNP
cord-259603-bh198xgl	491	41	RdRp	RdRp	NNP
cord-259603-bh198xgl	492	1	(	(	-LRB-
cord-259603-bh198xgl	492	2	Deng	Deng	NNP
cord-259603-bh198xgl	492	3	et	et	NNP
cord-259603-bh198xgl	492	4	al	al	NNP
cord-259603-bh198xgl	492	5	.	.	NNP
cord-259603-bh198xgl	492	6	,	,	,
cord-259603-bh198xgl	492	7	2014	2014	CD
cord-259603-bh198xgl	492	8	)	)	-RRB-
cord-259603-bh198xgl	492	9	.	.	.
cord-259603-bh198xgl	493	1	Clearly	clearly	RB
cord-259603-bh198xgl	493	2	,	,	,
cord-259603-bh198xgl	493	3	this	this	DT
cord-259603-bh198xgl	493	4	is	be	VBZ
cord-259603-bh198xgl	493	5	just	just	RB
cord-259603-bh198xgl	493	6	one	one	CD
cord-259603-bh198xgl	493	7	of	of	IN
cord-259603-bh198xgl	493	8	the	the	DT
cord-259603-bh198xgl	493	9	scenarios	scenario	NNS
cord-259603-bh198xgl	493	10	for	for	IN
cord-259603-bh198xgl	493	11	the	the	DT
cord-259603-bh198xgl	493	12	involvement	involvement	NN
cord-259603-bh198xgl	493	13	of	of	IN
cord-259603-bh198xgl	493	14	the	the	DT
cord-259603-bh198xgl	493	15	helicase	helicase	NN
cord-259603-bh198xgl	493	16	in	in	IN
cord-259603-bh198xgl	493	17	the	the	DT
cord-259603-bh198xgl	493	18	posttranscriptional	posttranscriptional	JJ
cord-259603-bh198xgl	493	19	fate	fate	NN
cord-259603-bh198xgl	493	20	of	of	IN
cord-259603-bh198xgl	493	21	viral	viral	JJ
cord-259603-bh198xgl	493	22	RNA	RNA	NNP
cord-259603-bh198xgl	493	23	products	product	NNS
cord-259603-bh198xgl	493	24	.	.	.
cord-259603-bh198xgl	494	1	Further	further	JJ
cord-259603-bh198xgl	494	2	experimental	experimental	JJ
cord-259603-bh198xgl	494	3	work	work	NN
cord-259603-bh198xgl	494	4	will	will	MD
cord-259603-bh198xgl	494	5	be	be	VB
cord-259603-bh198xgl	494	6	needed	need	VBN
cord-259603-bh198xgl	494	7	to	to	TO
cord-259603-bh198xgl	494	8	explore	explore	VB
cord-259603-bh198xgl	494	9	these	these	DT
cord-259603-bh198xgl	494	10	possibilities	possibility	NNS
cord-259603-bh198xgl	494	11	in	in	IN
cord-259603-bh198xgl	494	12	more	more	JJR
cord-259603-bh198xgl	494	13	detail	detail	NN
cord-259603-bh198xgl	494	14	,	,	,
cord-259603-bh198xgl	494	15	as	as	IN
cord-259603-bh198xgl	494	16	they	-PRON-	PRP
cord-259603-bh198xgl	494	17	are	be	VBP
cord-259603-bh198xgl	494	18	compatible	compatible	JJ
cord-259603-bh198xgl	494	19	with	with	IN
cord-259603-bh198xgl	494	20	the	the	DT
cord-259603-bh198xgl	494	21	much	much	RB
cord-259603-bh198xgl	494	22	broader	broad	JJR
cord-259603-bh198xgl	494	23	realization	realization	NN
cord-259603-bh198xgl	494	24	that	that	IN
cord-259603-bh198xgl	494	25	the	the	DT
cord-259603-bh198xgl	494	26	functions	function	NNS
cord-259603-bh198xgl	494	27	of	of	IN
cord-259603-bh198xgl	494	28	RNA	RNA	NNP
cord-259603-bh198xgl	494	29	helicases	helicase	NNS
cord-259603-bh198xgl	494	30	can	can	MD
cord-259603-bh198xgl	494	31	extend	extend	VB
cord-259603-bh198xgl	494	32	far	far	RB
cord-259603-bh198xgl	494	33	beyond	beyond	IN
cord-259603-bh198xgl	494	34	merely	merely	RB
cord-259603-bh198xgl	494	35	the	the	DT
cord-259603-bh198xgl	494	36	unwinding	unwinding	NN
cord-259603-bh198xgl	494	37	of	of	IN
cord-259603-bh198xgl	494	38	RNA	RNA	NNP
cord-259603-bh198xgl	494	39	structure	structure	NN
cord-259603-bh198xgl	494	40	.	.	.
cord-259603-bh198xgl	495	1	Due	due	IN
cord-259603-bh198xgl	495	2	to	to	IN
cord-259603-bh198xgl	495	3	its	-PRON-	PRP$
cord-259603-bh198xgl	495	4	multifunctionality	multifunctionality	NN
cord-259603-bh198xgl	495	5	and	and	CC
cord-259603-bh198xgl	495	6	involvement	involvement	NN
cord-259603-bh198xgl	495	7	in	in	IN
cord-259603-bh198xgl	495	8	several	several	JJ
cord-259603-bh198xgl	495	9	key	key	JJ
cord-259603-bh198xgl	495	10	processes	process	NNS
cord-259603-bh198xgl	495	11	in	in	IN
cord-259603-bh198xgl	495	12	viral	viral	JJ
cord-259603-bh198xgl	495	13	RNA	RNA	NNP
cord-259603-bh198xgl	495	14	synthesis	synthesis	NN
cord-259603-bh198xgl	495	15	and	and	CC
cord-259603-bh198xgl	495	16	processing	processing	NN
cord-259603-bh198xgl	495	17	,	,	,
cord-259603-bh198xgl	495	18	the	the	DT
cord-259603-bh198xgl	495	19	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	495	20	helicase	helicase	NNP
cord-259603-bh198xgl	495	21	is	be	VBZ
cord-259603-bh198xgl	495	22	an	an	DT
cord-259603-bh198xgl	495	23	important	important	JJ
cord-259603-bh198xgl	495	24	target	target	NN
cord-259603-bh198xgl	495	25	for	for	IN
cord-259603-bh198xgl	495	26	antiviral	antiviral	JJ
cord-259603-bh198xgl	495	27	drug	drug	NN
cord-259603-bh198xgl	495	28	development	development	NN
cord-259603-bh198xgl	495	29	,	,	,
cord-259603-bh198xgl	495	30	which	which	WDT
cord-259603-bh198xgl	495	31	was	be	VBD
cord-259603-bh198xgl	495	32	mainly	mainly	RB
cord-259603-bh198xgl	495	33	explored	explore	VBN
cord-259603-bh198xgl	495	34	for	for	IN
cord-259603-bh198xgl	495	35	CoVs	CoVs	NNP
cord-259603-bh198xgl	495	36	following	follow	VBG
cord-259603-bh198xgl	495	37	the	the	DT
cord-259603-bh198xgl	495	38	SARS	SARS	NNP
cord-259603-bh198xgl	495	39	-	-	HYPH
cord-259603-bh198xgl	495	40	CoV	CoV	NNP
cord-259603-bh198xgl	495	41	outbreak	outbreak	NN
cord-259603-bh198xgl	495	42	.	.	.
cord-259603-bh198xgl	496	1	The	the	DT
cord-259603-bh198xgl	496	2	highly	highly	RB
cord-259603-bh198xgl	496	3	conserved	conserved	JJ
cord-259603-bh198xgl	496	4	nature	nature	NN
cord-259603-bh198xgl	496	5	of	of	IN
cord-259603-bh198xgl	496	6	the	the	DT
cord-259603-bh198xgl	496	7	helicase	helicase	NN
cord-259603-bh198xgl	496	8	offers	offer	VBZ
cord-259603-bh198xgl	496	9	the	the	DT
cord-259603-bh198xgl	496	10	interesting	interesting	JJ
cord-259603-bh198xgl	496	11	perspective	perspective	NN
cord-259603-bh198xgl	496	12	of	of	IN
cord-259603-bh198xgl	496	13	developing	develop	VBG
cord-259603-bh198xgl	496	14	inhibitors	inhibitor	NNS
cord-259603-bh198xgl	496	15	with	with	IN
cord-259603-bh198xgl	496	16	a	a	DT
cord-259603-bh198xgl	496	17	potential	potential	JJ
cord-259603-bh198xgl	496	18	broad	broad	JJ
cord-259603-bh198xgl	496	19	-	-	HYPH
cord-259603-bh198xgl	496	20	spectrum	spectrum	NN
cord-259603-bh198xgl	496	21	activity	activity	NN
cord-259603-bh198xgl	496	22	.	.	.
cord-259603-bh198xgl	497	1	On	on	IN
cord-259603-bh198xgl	497	2	the	the	DT
cord-259603-bh198xgl	497	3	other	other	JJ
cord-259603-bh198xgl	497	4	hand	hand	NN
cord-259603-bh198xgl	497	5	,	,	,
cord-259603-bh198xgl	497	6	avoiding	avoid	VBG
cord-259603-bh198xgl	497	7	toxicity	toxicity	NN
cord-259603-bh198xgl	497	8	resulting	result	VBG
cord-259603-bh198xgl	497	9	from	from	IN
cord-259603-bh198xgl	497	10	inhibition	inhibition	NN
cord-259603-bh198xgl	497	11	of	of	IN
cord-259603-bh198xgl	497	12	the	the	DT
cord-259603-bh198xgl	497	13	abundant	abundant	JJ
cord-259603-bh198xgl	497	14	cellular	cellular	JJ
cord-259603-bh198xgl	497	15	NTPases	ntpase	NNS
cord-259603-bh198xgl	497	16	/	/	SYM
cord-259603-bh198xgl	497	17	helicases	helicase	NNS
cord-259603-bh198xgl	497	18	poses	pose	VBZ
cord-259603-bh198xgl	497	19	a	a	DT
cord-259603-bh198xgl	497	20	serious	serious	JJ
cord-259603-bh198xgl	497	21	challenge	challenge	NN
cord-259603-bh198xgl	497	22	,	,	,
cord-259603-bh198xgl	497	23	which	which	WDT
cord-259603-bh198xgl	497	24	is	be	VBZ
cord-259603-bh198xgl	497	25	why	why	WRB
cord-259603-bh198xgl	497	26	-	-	:
cord-259603-bh198xgl	497	27	as	as	IN
cord-259603-bh198xgl	497	28	in	in	IN
cord-259603-bh198xgl	497	29	the	the	DT
cord-259603-bh198xgl	497	30	case	case	NN
cord-259603-bh198xgl	497	31	of	of	IN
cord-259603-bh198xgl	497	32	the	the	DT
cord-259603-bh198xgl	497	33	RdRp	RdRp	NNP
cord-259603-bh198xgl	497	34	-	-	HYPH
cord-259603-bh198xgl	497	35	obtaining	obtain	VBG
cord-259603-bh198xgl	497	36	a	a	DT
cord-259603-bh198xgl	497	37	crystal	crystal	JJ
cord-259603-bh198xgl	497	38	structure	structure	NN
cord-259603-bh198xgl	497	39	for	for	IN
cord-259603-bh198xgl	497	40	a	a	DT
cord-259603-bh198xgl	497	41	CoV	cov	NN
cord-259603-bh198xgl	497	42	helicase	helicase	NN
cord-259603-bh198xgl	497	43	should	should	MD
cord-259603-bh198xgl	497	44	be	be	VB
cord-259603-bh198xgl	497	45	considered	consider	VBN
cord-259603-bh198xgl	497	46	a	a	DT
cord-259603-bh198xgl	497	47	research	research	NN
cord-259603-bh198xgl	497	48	priority	priority	NN
cord-259603-bh198xgl	497	49	.	.	.
cord-259603-bh198xgl	498	1	In	in	IN
cord-259603-bh198xgl	498	2	theory	theory	NN
cord-259603-bh198xgl	498	3	,	,	,
cord-259603-bh198xgl	498	4	a	a	DT
cord-259603-bh198xgl	498	5	variety	variety	NN
cord-259603-bh198xgl	498	6	of	of	IN
cord-259603-bh198xgl	498	7	helicase	helicase	NN
cord-259603-bh198xgl	498	8	properties	property	NNS
cord-259603-bh198xgl	498	9	may	may	MD
cord-259603-bh198xgl	498	10	be	be	VB
cord-259603-bh198xgl	498	11	targeted	target	VBN
cord-259603-bh198xgl	498	12	with	with	IN
cord-259603-bh198xgl	498	13	specific	specific	JJ
cord-259603-bh198xgl	498	14	inhibitors	inhibitor	NNS
cord-259603-bh198xgl	498	15	,	,	,
cord-259603-bh198xgl	498	16	ranging	range	VBG
cord-259603-bh198xgl	498	17	from	from	IN
cord-259603-bh198xgl	498	18	the	the	DT
cord-259603-bh198xgl	498	19	active	active	JJ
cord-259603-bh198xgl	498	20	and	and	CC
cord-259603-bh198xgl	498	21	nucleic	nucleic	JJ
cord-259603-bh198xgl	498	22	acid	acid	NN
cord-259603-bh198xgl	498	23	-	-	HYPH
cord-259603-bh198xgl	498	24	binding	bind	VBG
cord-259603-bh198xgl	498	25	sites	site	NNS
cord-259603-bh198xgl	498	26	of	of	IN
cord-259603-bh198xgl	498	27	the	the	DT
cord-259603-bh198xgl	498	28	enzyme	enzyme	NN
cord-259603-bh198xgl	498	29	to	to	IN
cord-259603-bh198xgl	498	30	interaction	interaction	NN
cord-259603-bh198xgl	498	31	surfaces	surface	NNS
cord-259603-bh198xgl	498	32	for	for	IN
cord-259603-bh198xgl	498	33	multimerization	multimerization	NN
cord-259603-bh198xgl	498	34	and	and	CC
cord-259603-bh198xgl	498	35	modulation	modulation	NN
cord-259603-bh198xgl	498	36	by	by	IN
cord-259603-bh198xgl	498	37	protein	protein	NN
cord-259603-bh198xgl	498	38	cofactors	cofactor	NNS
cord-259603-bh198xgl	499	1	(	(	-LRB-
cord-259603-bh198xgl	499	2	Kwong	Kwong	NNP
cord-259603-bh198xgl	499	3	et	et	NNP
cord-259603-bh198xgl	499	4	al	al	NNP
cord-259603-bh198xgl	499	5	.	.	NNP
cord-259603-bh198xgl	499	6	,	,	,
cord-259603-bh198xgl	499	7	2005	2005	CD
cord-259603-bh198xgl	499	8	)	)	-RRB-
cord-259603-bh198xgl	499	9	.	.	.
cord-259603-bh198xgl	500	1	Several	several	JJ
cord-259603-bh198xgl	500	2	compound	compound	NN
cord-259603-bh198xgl	500	3	families	family	NNS
cord-259603-bh198xgl	500	4	were	be	VBD
cord-259603-bh198xgl	500	5	found	find	VBN
cord-259603-bh198xgl	500	6	to	to	TO
cord-259603-bh198xgl	500	7	target	target	VB
cord-259603-bh198xgl	500	8	the	the	DT
cord-259603-bh198xgl	500	9	ATPase	ATPase	NNP
cord-259603-bh198xgl	500	10	of	of	IN
cord-259603-bh198xgl	500	11	nsp13	nsp13	NNP
cord-259603-bh198xgl	500	12	,	,	,
cord-259603-bh198xgl	500	13	and	and	CC
cord-259603-bh198xgl	500	14	thus	thus	RB
cord-259603-bh198xgl	500	15	also	also	RB
cord-259603-bh198xgl	500	16	its	-PRON-	PRP$
cord-259603-bh198xgl	500	17	helicase	helicase	NN
cord-259603-bh198xgl	500	18	activity	activity	NN
cord-259603-bh198xgl	500	19	.	.	.
cord-259603-bh198xgl	501	1	These	these	DT
cord-259603-bh198xgl	501	2	include	include	VBP
cord-259603-bh198xgl	501	3	naturally	naturally	RB
cord-259603-bh198xgl	501	4	occurring	occur	VBG
cord-259603-bh198xgl	501	5	flavonoids	flavonoid	NNS
cord-259603-bh198xgl	501	6	(	(	-LRB-
cord-259603-bh198xgl	501	7	Yu	Yu	NNP
cord-259603-bh198xgl	501	8	et	et	FW
cord-259603-bh198xgl	501	9	al	al	NNP
cord-259603-bh198xgl	501	10	.	.	NNP
cord-259603-bh198xgl	501	11	,	,	,
cord-259603-bh198xgl	501	12	2012	2012	CD
cord-259603-bh198xgl	501	13	)	)	-RRB-
cord-259603-bh198xgl	501	14	,	,	,
cord-259603-bh198xgl	501	15	chromones	chromone	NNS
cord-259603-bh198xgl	501	16	(	(	-LRB-
cord-259603-bh198xgl	501	17	Kim	Kim	NNP
cord-259603-bh198xgl	501	18	et	et	NNP
cord-259603-bh198xgl	501	19	al	al	NNP
cord-259603-bh198xgl	501	20	.	.	NNP
cord-259603-bh198xgl	501	21	,	,	,
cord-259603-bh198xgl	501	22	2011	2011	CD
cord-259603-bh198xgl	501	23	)	)	-RRB-
cord-259603-bh198xgl	501	24	,	,	,
cord-259603-bh198xgl	501	25	and	and	CC
cord-259603-bh198xgl	501	26	bananins	bananin	NNS
cord-259603-bh198xgl	501	27	(	(	-LRB-
cord-259603-bh198xgl	501	28	Kesel	Kesel	NNP
cord-259603-bh198xgl	501	29	,	,	,
cord-259603-bh198xgl	501	30	2005	2005	CD
cord-259603-bh198xgl	501	31	;	;	:
cord-259603-bh198xgl	501	32	Tanner	Tanner	NNP
cord-259603-bh198xgl	501	33	et	et	NNP
cord-259603-bh198xgl	501	34	al	al	NNP
cord-259603-bh198xgl	501	35	.	.	NNP
cord-259603-bh198xgl	501	36	,	,	,
cord-259603-bh198xgl	501	37	2005	2005	CD
cord-259603-bh198xgl	501	38	)	)	-RRB-
cord-259603-bh198xgl	501	39	,	,	,
cord-259603-bh198xgl	501	40	all	all	DT
cord-259603-bh198xgl	501	41	exhibiting	exhibit	VBG
cord-259603-bh198xgl	501	42	in	in	IN
cord-259603-bh198xgl	501	43	vitro	vitro	FW
cord-259603-bh198xgl	501	44	IC	IC	NNP
cord-259603-bh198xgl	501	45	50	50	CD
cord-259603-bh198xgl	501	46	values	value	NNS
cord-259603-bh198xgl	501	47	in	in	IN
cord-259603-bh198xgl	501	48	the	the	DT
cord-259603-bh198xgl	501	49	low	low	JJ
cord-259603-bh198xgl	501	50	-	-	HYPH
cord-259603-bh198xgl	501	51	micromolar	micromolar	JJ
cord-259603-bh198xgl	501	52	range	range	NN
cord-259603-bh198xgl	501	53	.	.	.
cord-259603-bh198xgl	502	1	Other	other	JJ
cord-259603-bh198xgl	502	2	compounds	compound	NNS
cord-259603-bh198xgl	502	3	appear	appear	VBP
cord-259603-bh198xgl	502	4	to	to	TO
cord-259603-bh198xgl	502	5	target	target	VB
cord-259603-bh198xgl	502	6	the	the	DT
cord-259603-bh198xgl	502	7	helicase	helicase	NN
cord-259603-bh198xgl	502	8	of	of	IN
cord-259603-bh198xgl	502	9	nsp13	nsp13	NNP
cord-259603-bh198xgl	502	10	activity	activity	NN
cord-259603-bh198xgl	502	11	more	more	RBR
cord-259603-bh198xgl	502	12	specifically	specifically	RB
cord-259603-bh198xgl	502	13	,	,	,
cord-259603-bh198xgl	502	14	like	like	IN
cord-259603-bh198xgl	502	15	the	the	DT
cord-259603-bh198xgl	502	16	triazole	triazole	NNP
cord-259603-bh198xgl	502	17	SSYA10	SSYA10	NNP
cord-259603-bh198xgl	502	18	-	-	HYPH
cord-259603-bh198xgl	502	19	001	001	NNP
cord-259603-bh198xgl	502	20	,	,	,
cord-259603-bh198xgl	502	21	which	which	WDT
cord-259603-bh198xgl	502	22	was	be	VBD
cord-259603-bh198xgl	502	23	found	find	VBN
cord-259603-bh198xgl	502	24	to	to	TO
cord-259603-bh198xgl	502	25	inhibit	inhibit	VB
cord-259603-bh198xgl	502	26	the	the	DT
cord-259603-bh198xgl	502	27	replication	replication	NN
cord-259603-bh198xgl	502	28	of	of	IN
cord-259603-bh198xgl	502	29	multiple	multiple	JJ
cord-259603-bh198xgl	502	30	beta	beta	JJ
cord-259603-bh198xgl	502	31	-	-	HYPH
cord-259603-bh198xgl	502	32	CoVs	covs	JJ
cord-259603-bh198xgl	502	33	(	(	-LRB-
cord-259603-bh198xgl	502	34	SARS	SARS	NNP
cord-259603-bh198xgl	502	35	-	-	HYPH
cord-259603-bh198xgl	502	36	CoV	CoV	NNP
cord-259603-bh198xgl	502	37	,	,	,
cord-259603-bh198xgl	502	38	MERS	MERS	NNP
cord-259603-bh198xgl	502	39	-	-	HYPH
cord-259603-bh198xgl	502	40	CoV	CoV	NNP
cord-259603-bh198xgl	502	41	,	,	,
cord-259603-bh198xgl	502	42	and	and	CC
cord-259603-bh198xgl	502	43	MHV	MHV	NNP
cord-259603-bh198xgl	502	44	)	)	-RRB-
cord-259603-bh198xgl	502	45	in	in	IN
cord-259603-bh198xgl	502	46	cell	cell	NN
cord-259603-bh198xgl	502	47	culture	culture	NN
cord-259603-bh198xgl	502	48	-	-	HYPH
cord-259603-bh198xgl	502	49	based	base	VBN
cord-259603-bh198xgl	502	50	infection	infection	NN
cord-259603-bh198xgl	502	51	models	model	NNS
cord-259603-bh198xgl	502	52	(	(	-LRB-
cord-259603-bh198xgl	503	1	Adedeji	Adedeji	NNP
cord-259603-bh198xgl	503	2	et	et	NNP
cord-259603-bh198xgl	503	3	al	al	NNP
cord-259603-bh198xgl	503	4	.	.	.
cord-259603-bh198xgl	504	1	,	,	,
cord-259603-bh198xgl	504	2	2012b	2012b	CD
cord-259603-bh198xgl	505	1	(	(	-LRB-
cord-259603-bh198xgl	505	2	Adedeji	Adedeji	NNP
cord-259603-bh198xgl	505	3	et	et	NNP
cord-259603-bh198xgl	505	4	al	al	NNP
cord-259603-bh198xgl	505	5	.	.	.
cord-259603-bh198xgl	506	1	,	,	,
cord-259603-bh198xgl	506	2	,	,	,
cord-259603-bh198xgl	506	3	2014	2014	CD
cord-259603-bh198xgl	506	4	.	.	.
cord-259603-bh198xgl	507	1	The	the	DT
cord-259603-bh198xgl	507	2	IC	IC	NNP
cord-259603-bh198xgl	507	3	50	50	CD
cord-259603-bh198xgl	507	4	value	value	NN
cord-259603-bh198xgl	507	5	in	in	IN
cord-259603-bh198xgl	508	1	in	in	IN
cord-259603-bh198xgl	508	2	vitro	vitro	FW
cord-259603-bh198xgl	508	3	helicase	helicase	NNP
cord-259603-bh198xgl	508	4	assays	assay	NNS
cord-259603-bh198xgl	508	5	was	be	VBD
cord-259603-bh198xgl	508	6	about	about	RB
cord-259603-bh198xgl	508	7	5.5	5.5	CD
cord-259603-bh198xgl	508	8	μM	μm	CD
cord-259603-bh198xgl	508	9	,	,	,
cord-259603-bh198xgl	508	10	whereas	whereas	IN
cord-259603-bh198xgl	508	11	EC	EC	NNP
cord-259603-bh198xgl	508	12	50	50	CD
cord-259603-bh198xgl	508	13	values	value	NNS
cord-259603-bh198xgl	508	14	in	in	IN
cord-259603-bh198xgl	508	15	cell	cell	NN
cord-259603-bh198xgl	508	16	cultures	culture	NNS
cord-259603-bh198xgl	508	17	assays	assay	NNS
cord-259603-bh198xgl	508	18	were	be	VBD
cord-259603-bh198xgl	508	19	in	in	IN
cord-259603-bh198xgl	508	20	the	the	DT
cord-259603-bh198xgl	508	21	range	range	NN
cord-259603-bh198xgl	508	22	of	of	IN
cord-259603-bh198xgl	508	23	7	7	CD
cord-259603-bh198xgl	508	24	-	-	SYM
cord-259603-bh198xgl	508	25	25	25	CD
cord-259603-bh198xgl	508	26	μM	μm	NN
cord-259603-bh198xgl	508	27	,	,	,
cord-259603-bh198xgl	508	28	depending	depend	VBG
cord-259603-bh198xgl	508	29	on	on	IN
cord-259603-bh198xgl	508	30	the	the	DT
cord-259603-bh198xgl	508	31	CoV	cov	NN
cord-259603-bh198xgl	508	32	analyzed	analyze	VBN
cord-259603-bh198xgl	508	33	,	,	,
cord-259603-bh198xgl	508	34	suggesting	suggest	VBG
cord-259603-bh198xgl	508	35	that	that	IN
cord-259603-bh198xgl	508	36	broad	broad	JJ
cord-259603-bh198xgl	508	37	-	-	HYPH
cord-259603-bh198xgl	508	38	spectrum	spectrum	NN
cord-259603-bh198xgl	508	39	activity	activity	NN
cord-259603-bh198xgl	508	40	may	may	MD
cord-259603-bh198xgl	508	41	indeed	indeed	RB
cord-259603-bh198xgl	508	42	be	be	VB
cord-259603-bh198xgl	508	43	achieved	achieve	VBN
cord-259603-bh198xgl	508	44	.	.	.
cord-259603-bh198xgl	509	1	To	to	IN
cord-259603-bh198xgl	509	2	our	-PRON-	PRP$
cord-259603-bh198xgl	509	3	knowledge	knowledge	NN
cord-259603-bh198xgl	509	4	,	,	,
cord-259603-bh198xgl	509	5	the	the	DT
cord-259603-bh198xgl	509	6	antiviral	antiviral	JJ
cord-259603-bh198xgl	509	7	potential	potential	NN
cord-259603-bh198xgl	509	8	and	and	CC
cord-259603-bh198xgl	509	9	toxicity	toxicity	NN
cord-259603-bh198xgl	509	10	of	of	IN
cord-259603-bh198xgl	509	11	SSYA10	SSYA10	NNP
cord-259603-bh198xgl	509	12	-	-	HYPH
cord-259603-bh198xgl	509	13	001	001	CD
cord-259603-bh198xgl	509	14	in	in	IN
cord-259603-bh198xgl	509	15	animal	animal	NN
cord-259603-bh198xgl	509	16	models	model	NNS
cord-259603-bh198xgl	509	17	remain	remain	VBP
cord-259603-bh198xgl	509	18	to	to	TO
cord-259603-bh198xgl	509	19	be	be	VB
cord-259603-bh198xgl	509	20	tested	test	VBN
cord-259603-bh198xgl	509	21	.	.	.
cord-259603-bh198xgl	510	1	Another	another	DT
cord-259603-bh198xgl	510	2	interesting	interesting	JJ
cord-259603-bh198xgl	510	3	group	group	NN
cord-259603-bh198xgl	510	4	of	of	IN
cord-259603-bh198xgl	510	5	helicase	helicase	NN
cord-259603-bh198xgl	510	6	-	-	HYPH
cord-259603-bh198xgl	510	7	directed	direct	VBN
cord-259603-bh198xgl	510	8	antiviral	antiviral	JJ
cord-259603-bh198xgl	510	9	hits	hit	NNS
cord-259603-bh198xgl	510	10	are	be	VBP
cord-259603-bh198xgl	510	11	bismuth	bismuth	NN
cord-259603-bh198xgl	510	12	complexes	complex	NNS
cord-259603-bh198xgl	510	13	,	,	,
cord-259603-bh198xgl	510	14	which	which	WDT
cord-259603-bh198xgl	510	15	were	be	VBD
cord-259603-bh198xgl	510	16	postulated	postulate	VBN
cord-259603-bh198xgl	510	17	to	to	TO
cord-259603-bh198xgl	510	18	inhibit	inhibit	VB
cord-259603-bh198xgl	510	19	the	the	DT
cord-259603-bh198xgl	510	20	NTPase	NTPase	NNP
cord-259603-bh198xgl	510	21	and	and	CC
cord-259603-bh198xgl	510	22	helicase	helicase	NN
cord-259603-bh198xgl	510	23	functions	function	NNS
cord-259603-bh198xgl	510	24	by	by	IN
cord-259603-bh198xgl	510	25	competing	compete	VBG
cord-259603-bh198xgl	510	26	for	for	IN
cord-259603-bh198xgl	510	27	zinc	zinc	NN
cord-259603-bh198xgl	510	28	ions	ion	NNS
cord-259603-bh198xgl	510	29	with	with	IN
cord-259603-bh198xgl	510	30	the	the	DT
cord-259603-bh198xgl	510	31	ZBD	ZBD	NNP
cord-259603-bh198xgl	510	32	.	.	.
cord-259603-bh198xgl	511	1	In	in	IN
cord-259603-bh198xgl	511	2	SARS	SARS	NNP
cord-259603-bh198xgl	511	3	-	-	HYPH
cord-259603-bh198xgl	511	4	CoV	CoV	NNP
cord-259603-bh198xgl	511	5	-	-	HYPH
cord-259603-bh198xgl	511	6	infected	infect	VBN
cord-259603-bh198xgl	511	7	cell	cell	NN
cord-259603-bh198xgl	511	8	cultures	culture	NNS
cord-259603-bh198xgl	511	9	the	the	DT
cord-259603-bh198xgl	511	10	determined	determined	JJ
cord-259603-bh198xgl	511	11	EC	EC	NNP
cord-259603-bh198xgl	511	12	50	50	CD
cord-259603-bh198xgl	511	13	and	and	CC
cord-259603-bh198xgl	511	14	CC	cc	NN
cord-259603-bh198xgl	511	15	50	50	CD
cord-259603-bh198xgl	511	16	values	value	NNS
cord-259603-bh198xgl	511	17	were	be	VBD
cord-259603-bh198xgl	511	18	6	6	CD
cord-259603-bh198xgl	511	19	μM	μm	NN
cord-259603-bh198xgl	511	20	and	and	CC
cord-259603-bh198xgl	511	21	5	5	CD
cord-259603-bh198xgl	511	22	mM	mm	CD
cord-259603-bh198xgl	511	23	,	,	,
cord-259603-bh198xgl	511	24	respectively	respectively	RB
cord-259603-bh198xgl	511	25	(	(	-LRB-
cord-259603-bh198xgl	511	26	Yang	Yang	NNP
cord-259603-bh198xgl	511	27	et	et	NNP
cord-259603-bh198xgl	511	28	al	al	NNP
cord-259603-bh198xgl	511	29	.	.	NNP
cord-259603-bh198xgl	511	30	,	,	,
cord-259603-bh198xgl	511	31	2007	2007	CD
cord-259603-bh198xgl	511	32	)	)	-RRB-
cord-259603-bh198xgl	511	33	.	.	.
cord-259603-bh198xgl	512	1	nsp10	nsp10	NNPS
cord-259603-bh198xgl	512	2	-	-	HYPH
cord-259603-bh198xgl	512	3	13	13	CD
cord-259603-bh198xgl	512	4	-	-	HYPH
cord-259603-bh198xgl	512	5	14	14	CD
cord-259603-bh198xgl	512	6	-	-	SYM
cord-259603-bh198xgl	512	7	16	16	CD
cord-259603-bh198xgl	512	8	Cap	Cap	NNP
cord-259603-bh198xgl	512	9	structures	structure	NNS
cord-259603-bh198xgl	512	10	consists	consist	VBZ
cord-259603-bh198xgl	512	11	of	of	IN
cord-259603-bh198xgl	512	12	a	a	DT
cord-259603-bh198xgl	512	13	7-methylguanosine	7-methylguanosine	CD
cord-259603-bh198xgl	512	14	(	(	-LRB-
cord-259603-bh198xgl	512	15	m7	m7	NN
cord-259603-bh198xgl	512	16	G	g	NN
cord-259603-bh198xgl	512	17	)	)	-RRB-
cord-259603-bh198xgl	512	18	linked	link	VBN
cord-259603-bh198xgl	512	19	to	to	IN
cord-259603-bh198xgl	512	20	the	the	DT
cord-259603-bh198xgl	512	21	first	first	JJ
cord-259603-bh198xgl	512	22	nucleotide	nucleotide	NN
cord-259603-bh198xgl	512	23	of	of	IN
cord-259603-bh198xgl	512	24	the	the	DT
cord-259603-bh198xgl	512	25	RNA	RNA	NNP
cord-259603-bh198xgl	512	26	transcript	transcript	NN
cord-259603-bh198xgl	512	27	through	through	IN
cord-259603-bh198xgl	512	28	a	a	DT
cord-259603-bh198xgl	512	29	5	5	CD
cord-259603-bh198xgl	512	30	0	0	CD
cord-259603-bh198xgl	512	31	-5	-5	CD
cord-259603-bh198xgl	512	32	0	0	CD
cord-259603-bh198xgl	512	33	triphosphate	triphosphate	NN
cord-259603-bh198xgl	512	34	bridge	bridge	NN
cord-259603-bh198xgl	512	35	(	(	-LRB-
cord-259603-bh198xgl	512	36	for	for	IN
cord-259603-bh198xgl	512	37	a	a	DT
cord-259603-bh198xgl	512	38	review	review	NN
cord-259603-bh198xgl	512	39	,	,	,
cord-259603-bh198xgl	512	40	see	see	VB
cord-259603-bh198xgl	512	41	Decroly	Decroly	NNP
cord-259603-bh198xgl	512	42	et	et	NNP
cord-259603-bh198xgl	512	43	al	al	NNP
cord-259603-bh198xgl	512	44	.	.	NNP
cord-259603-bh198xgl	512	45	,	,	,
cord-259603-bh198xgl	512	46	2012	2012	CD
cord-259603-bh198xgl	512	47	)	)	-RRB-
cord-259603-bh198xgl	512	48	.	.	.
cord-259603-bh198xgl	513	1	In	in	IN
cord-259603-bh198xgl	513	2	eukaryotic	eukaryotic	JJ
cord-259603-bh198xgl	513	3	cells	cell	NNS
cord-259603-bh198xgl	513	4	,	,	,
cord-259603-bh198xgl	513	5	the	the	DT
cord-259603-bh198xgl	513	6	synthesis	synthesis	NN
cord-259603-bh198xgl	513	7	of	of	IN
cord-259603-bh198xgl	513	8	the	the	DT
cord-259603-bh198xgl	513	9	cap	cap	NN
cord-259603-bh198xgl	513	10	structure	structure	NN
cord-259603-bh198xgl	513	11	is	be	VBZ
cord-259603-bh198xgl	513	12	a	a	DT
cord-259603-bh198xgl	513	13	multistep	multistep	JJ
cord-259603-bh198xgl	513	14	process	process	NN
cord-259603-bh198xgl	513	15	that	that	WDT
cord-259603-bh198xgl	513	16	occurs	occur	VBZ
cord-259603-bh198xgl	513	17	in	in	IN
cord-259603-bh198xgl	513	18	the	the	DT
cord-259603-bh198xgl	513	19	nucleus	nucleus	NN
cord-259603-bh198xgl	513	20	and	and	CC
cord-259603-bh198xgl	513	21	is	be	VBZ
cord-259603-bh198xgl	513	22	coupled	couple	VBN
cord-259603-bh198xgl	513	23	to	to	IN
cord-259603-bh198xgl	513	24	RNA	RNA	NNP
cord-259603-bh198xgl	513	25	pol	pol	NN
cord-259603-bh198xgl	513	26	II	II	NNP
cord-259603-bh198xgl	513	27	-	-	HYPH
cord-259603-bh198xgl	513	28	driven	drive	VBN
cord-259603-bh198xgl	513	29	transcription	transcription	NN
cord-259603-bh198xgl	513	30	(	(	-LRB-
cord-259603-bh198xgl	513	31	Shatkin	Shatkin	NNP
cord-259603-bh198xgl	513	32	,	,	,
cord-259603-bh198xgl	513	33	1976	1976	CD
cord-259603-bh198xgl	513	34	)	)	-RRB-
cord-259603-bh198xgl	513	35	.	.	.
cord-259603-bh198xgl	514	1	Capping	capping	NN
cord-259603-bh198xgl	514	2	begins	begin	VBZ
cord-259603-bh198xgl	514	3	with	with	IN
cord-259603-bh198xgl	514	4	the	the	DT
cord-259603-bh198xgl	514	5	hydrolysis	hydrolysis	NN
cord-259603-bh198xgl	514	6	of	of	IN
cord-259603-bh198xgl	514	7	the	the	DT
cord-259603-bh198xgl	514	8	5	5	CD
cord-259603-bh198xgl	514	9	0	0	CD
cord-259603-bh198xgl	514	10	γ	γ	NN
cord-259603-bh198xgl	514	11	-	-	HYPH
cord-259603-bh198xgl	514	12	phosphate	phosphate	NN
cord-259603-bh198xgl	514	13	of	of	IN
cord-259603-bh198xgl	514	14	the	the	DT
cord-259603-bh198xgl	514	15	nascent	nascent	JJ
cord-259603-bh198xgl	514	16	RNA	RNA	NNP
cord-259603-bh198xgl	514	17	transcript	transcript	NN
cord-259603-bh198xgl	514	18	by	by	IN
cord-259603-bh198xgl	514	19	an	an	DT
cord-259603-bh198xgl	514	20	RNA	RNA	NNP
cord-259603-bh198xgl	514	21	5	5	CD
cord-259603-bh198xgl	514	22	0	0	CD
cord-259603-bh198xgl	515	1	-triphosphatase	-triphosphatase	:
cord-259603-bh198xgl	515	2	(	(	-LRB-
cord-259603-bh198xgl	515	3	RTPase	RTPase	NNP
cord-259603-bh198xgl	515	4	)	)	-RRB-
cord-259603-bh198xgl	515	5	.	.	.
cord-259603-bh198xgl	516	1	Subsequently	subsequently	RB
cord-259603-bh198xgl	516	2	,	,	,
cord-259603-bh198xgl	516	3	a	a	DT
cord-259603-bh198xgl	516	4	GMP	GMP	NNP
cord-259603-bh198xgl	516	5	molecule	molecule	NN
cord-259603-bh198xgl	516	6	is	be	VBZ
cord-259603-bh198xgl	516	7	transferred	transfer	VBN
cord-259603-bh198xgl	516	8	to	to	IN
cord-259603-bh198xgl	516	9	the	the	DT
cord-259603-bh198xgl	516	10	5	5	CD
cord-259603-bh198xgl	516	11	0	0	CD
cord-259603-bh198xgl	516	12	-diphosphate	-diphosphate	CD
cord-259603-bh198xgl	516	13	of	of	IN
cord-259603-bh198xgl	516	14	the	the	DT
cord-259603-bh198xgl	516	15	RNA	RNA	NNP
cord-259603-bh198xgl	516	16	by	by	IN
cord-259603-bh198xgl	516	17	a	a	DT
cord-259603-bh198xgl	516	18	GTase	GTase	NNP
cord-259603-bh198xgl	516	19	,	,	,
cord-259603-bh198xgl	516	20	leading	lead	VBG
cord-259603-bh198xgl	516	21	to	to	IN
cord-259603-bh198xgl	516	22	the	the	DT
cord-259603-bh198xgl	516	23	formation	formation	NN
cord-259603-bh198xgl	516	24	of	of	IN
cord-259603-bh198xgl	516	25	GpppN	GpppN	NNP
cord-259603-bh198xgl	516	26	-	-	HYPH
cord-259603-bh198xgl	516	27	RNA	RNA	NNP
cord-259603-bh198xgl	516	28	.	.	.
cord-259603-bh198xgl	517	1	The	the	DT
cord-259603-bh198xgl	517	2	cap	cap	NN
cord-259603-bh198xgl	517	3	structure	structure	NN
cord-259603-bh198xgl	517	4	is	be	VBZ
cord-259603-bh198xgl	517	5	methylated	methylate	VBN
cord-259603-bh198xgl	517	6	at	at	IN
cord-259603-bh198xgl	517	7	the	the	DT
cord-259603-bh198xgl	517	8	N7	N7	NNP
cord-259603-bh198xgl	517	9	position	position	NN
cord-259603-bh198xgl	517	10	of	of	IN
cord-259603-bh198xgl	517	11	the	the	DT
cord-259603-bh198xgl	517	12	guanosine	guanosine	NN
cord-259603-bh198xgl	517	13	by	by	IN
cord-259603-bh198xgl	517	14	an	an	DT
cord-259603-bh198xgl	517	15	(	(	-LRB-
cord-259603-bh198xgl	517	16	AdoMet)-dependent	AdoMet)-dependent	NNP
cord-259603-bh198xgl	517	17	N7-MTase	N7-MTase	NNP
cord-259603-bh198xgl	517	18	,	,	,
cord-259603-bh198xgl	517	19	yielding	yield	VBG
cord-259603-bh198xgl	517	20	cap-0	cap-0	DT
cord-259603-bh198xgl	517	21	(	(	-LRB-
cord-259603-bh198xgl	517	22	m7	m7	NNP
cord-259603-bh198xgl	517	23	GpppN	GpppN	NNP
cord-259603-bh198xgl	517	24	)	)	-RRB-
cord-259603-bh198xgl	517	25	.	.	.
cord-259603-bh198xgl	518	1	The	the	DT
cord-259603-bh198xgl	518	2	cap-0	cap-0	NN
cord-259603-bh198xgl	518	3	structure	structure	NN
cord-259603-bh198xgl	518	4	is	be	VBZ
cord-259603-bh198xgl	518	5	then	then	RB
cord-259603-bh198xgl	518	6	converted	convert	VBN
cord-259603-bh198xgl	518	7	into	into	IN
cord-259603-bh198xgl	519	1	cap-1	cap-1	LS
cord-259603-bh198xgl	519	2	(	(	-LRB-
cord-259603-bh198xgl	519	3	m7	m7	NNP
cord-259603-bh198xgl	519	4	GpppN	GpppN	NNP
cord-259603-bh198xgl	519	5	2	2	CD
cord-259603-bh198xgl	519	6	0	0	CD
cord-259603-bh198xgl	519	7	-Om	-Om	NFP
cord-259603-bh198xgl	519	8	)	)	-RRB-
cord-259603-bh198xgl	519	9	or	or	CC
cord-259603-bh198xgl	520	1	cap-2	cap-2	LS
cord-259603-bh198xgl	520	2	by	by	IN
cord-259603-bh198xgl	520	3	an	an	DT
cord-259603-bh198xgl	520	4	AdoMet	AdoMet	NNP
cord-259603-bh198xgl	520	5	-	-	HYPH
cord-259603-bh198xgl	520	6	dependent	dependent	JJ
cord-259603-bh198xgl	520	7	2	2	CD
cord-259603-bh198xgl	520	8	0	0	CD
cord-259603-bh198xgl	520	9	-O	-o	CD
cord-259603-bh198xgl	520	10	-	-	:
cord-259603-bh198xgl	520	11	MTase	MTase	NNP
cord-259603-bh198xgl	520	12	that	that	WDT
cord-259603-bh198xgl	520	13	methylates	methylate	VBZ
cord-259603-bh198xgl	520	14	the	the	DT
cord-259603-bh198xgl	520	15	2	2	CD
cord-259603-bh198xgl	520	16	0	0	CD
cord-259603-bh198xgl	520	17	-O	-o	CD
cord-259603-bh198xgl	520	18	position	position	NN
cord-259603-bh198xgl	520	19	of	of	IN
cord-259603-bh198xgl	520	20	the	the	DT
cord-259603-bh198xgl	520	21	ribose	ribose	NN
cord-259603-bh198xgl	520	22	of	of	IN
cord-259603-bh198xgl	520	23	the	the	DT
cord-259603-bh198xgl	520	24	first	first	JJ
cord-259603-bh198xgl	520	25	or	or	CC
cord-259603-bh198xgl	520	26	first	first	JJ
cord-259603-bh198xgl	520	27	and	and	CC
cord-259603-bh198xgl	520	28	second	second	JJ
cord-259603-bh198xgl	520	29	RNA	RNA	NNP
cord-259603-bh198xgl	520	30	nucleotide	nucleotide	NN
cord-259603-bh198xgl	520	31	,	,	,
cord-259603-bh198xgl	520	32	respectively	respectively	RB
cord-259603-bh198xgl	520	33	.	.	.
cord-259603-bh198xgl	521	1	Due	due	IN
cord-259603-bh198xgl	521	2	to	to	IN
cord-259603-bh198xgl	521	3	the	the	DT
cord-259603-bh198xgl	521	4	cytoplasmic	cytoplasmic	JJ
cord-259603-bh198xgl	521	5	localization	localization	NN
cord-259603-bh198xgl	521	6	of	of	IN
cord-259603-bh198xgl	521	7	their	-PRON-	PRP$
cord-259603-bh198xgl	521	8	mRNA	mRNA	NNP
cord-259603-bh198xgl	521	9	synthesis	synthesis	NN
cord-259603-bh198xgl	521	10	,	,	,
cord-259603-bh198xgl	521	11	nidoviruses	nidoviruses	NNP
cord-259603-bh198xgl	521	12	,	,	,
cord-259603-bh198xgl	521	13	and	and	CC
cord-259603-bh198xgl	521	14	all	all	DT
cord-259603-bh198xgl	521	15	other	other	JJ
cord-259603-bh198xgl	521	16	+	+	CC
cord-259603-bh198xgl	521	17	RNA	rna	NN
cord-259603-bh198xgl	521	18	viruses	virus	NNS
cord-259603-bh198xgl	521	19	of	of	IN
cord-259603-bh198xgl	521	20	eukaryotes	eukaryote	NNS
cord-259603-bh198xgl	521	21	,	,	,
cord-259603-bh198xgl	521	22	can	can	MD
cord-259603-bh198xgl	521	23	not	not	RB
cord-259603-bh198xgl	521	24	rely	rely	VB
cord-259603-bh198xgl	521	25	on	on	IN
cord-259603-bh198xgl	521	26	the	the	DT
cord-259603-bh198xgl	521	27	standard	standard	JJ
cord-259603-bh198xgl	521	28	capping	cap	VBG
cord-259603-bh198xgl	521	29	pathway	pathway	NN
cord-259603-bh198xgl	521	30	outlined	outline	VBN
cord-259603-bh198xgl	521	31	earlier	early	RBR
cord-259603-bh198xgl	521	32	,	,	,
cord-259603-bh198xgl	521	33	which	which	WDT
cord-259603-bh198xgl	521	34	is	be	VBZ
cord-259603-bh198xgl	521	35	executed	execute	VBN
cord-259603-bh198xgl	521	36	by	by	IN
cord-259603-bh198xgl	521	37	host	host	NN
cord-259603-bh198xgl	521	38	cell	cell	NN
cord-259603-bh198xgl	521	39	enzymes	enzyme	NNS
cord-259603-bh198xgl	521	40	in	in	IN
cord-259603-bh198xgl	521	41	the	the	DT
cord-259603-bh198xgl	521	42	nucleus	nucleus	NN
cord-259603-bh198xgl	521	43	.	.	.
cord-259603-bh198xgl	522	1	Cap	cap	NN
cord-259603-bh198xgl	522	2	structures	structure	NNS
cord-259603-bh198xgl	522	3	can	can	MD
cord-259603-bh198xgl	522	4	protect	protect	VB
cord-259603-bh198xgl	522	5	viral	viral	JJ
cord-259603-bh198xgl	522	6	mRNAs	mrnas	IN
cord-259603-bh198xgl	522	7	from	from	IN
cord-259603-bh198xgl	522	8	degradation	degradation	NN
cord-259603-bh198xgl	522	9	by	by	IN
cord-259603-bh198xgl	522	10	the	the	DT
cord-259603-bh198xgl	522	11	cellular	cellular	JJ
cord-259603-bh198xgl	522	12	5	5	CD
cord-259603-bh198xgl	522	13	0	0	CD
cord-259603-bh198xgl	522	14	-to-3	-to-3	ADD
cord-259603-bh198xgl	522	15	0	0	CD
cord-259603-bh198xgl	522	16	exoribonuclases	exoribonuclase	NNS
cord-259603-bh198xgl	522	17	involved	involve	VBN
cord-259603-bh198xgl	522	18	in	in	IN
cord-259603-bh198xgl	522	19	RNA	RNA	NNP
cord-259603-bh198xgl	522	20	turnover	turnover	NN
cord-259603-bh198xgl	522	21	(	(	-LRB-
cord-259603-bh198xgl	522	22	Liu	Liu	NNP
cord-259603-bh198xgl	522	23	and	and	CC
cord-259603-bh198xgl	522	24	Kiledjian	Kiledjian	NNP
cord-259603-bh198xgl	522	25	,	,	,
cord-259603-bh198xgl	522	26	2006	2006	CD
cord-259603-bh198xgl	522	27	)	)	-RRB-
cord-259603-bh198xgl	522	28	.	.	.
cord-259603-bh198xgl	523	1	Cap	cap	NN
cord-259603-bh198xgl	523	2	methylation	methylation	NN
cord-259603-bh198xgl	523	3	is	be	VBZ
cord-259603-bh198xgl	523	4	critical	critical	JJ
cord-259603-bh198xgl	523	5	for	for	IN
cord-259603-bh198xgl	523	6	mRNA	mRNA	NNP
cord-259603-bh198xgl	523	7	recognition	recognition	NN
cord-259603-bh198xgl	523	8	by	by	IN
cord-259603-bh198xgl	523	9	translation	translation	NN
cord-259603-bh198xgl	523	10	initiation	initiation	NN
cord-259603-bh198xgl	523	11	factor	factor	NN
cord-259603-bh198xgl	523	12	eIF4E	eif4e	CD
cord-259603-bh198xgl	524	1	(	(	-LRB-
cord-259603-bh198xgl	524	2	Filipowicz	Filipowicz	NNP
cord-259603-bh198xgl	524	3	et	et	NNP
cord-259603-bh198xgl	524	4	al	al	NNP
cord-259603-bh198xgl	524	5	.	.	NNP
cord-259603-bh198xgl	524	6	,	,	,
cord-259603-bh198xgl	524	7	1976	1976	CD
cord-259603-bh198xgl	524	8	;	;	.
cord-259603-bh198xgl	525	1	Ohlmann	Ohlmann	NNP
cord-259603-bh198xgl	525	2	et	et	FW
cord-259603-bh198xgl	525	3	al	al	NNP
cord-259603-bh198xgl	525	4	.	.	NNP
cord-259603-bh198xgl	525	5	,	,	,
cord-259603-bh198xgl	525	6	1996	1996	CD
cord-259603-bh198xgl	525	7	)	)	-RRB-
cord-259603-bh198xgl	525	8	,	,	,
cord-259603-bh198xgl	525	9	and	and	CC
cord-259603-bh198xgl	525	10	thus	thus	RB
cord-259603-bh198xgl	525	11	for	for	IN
cord-259603-bh198xgl	525	12	viral	viral	JJ
cord-259603-bh198xgl	525	13	translation	translation	NN
cord-259603-bh198xgl	525	14	and	and	CC
cord-259603-bh198xgl	525	15	replication	replication	NN
cord-259603-bh198xgl	525	16	as	as	IN
cord-259603-bh198xgl	525	17	a	a	DT
cord-259603-bh198xgl	525	18	whole	whole	NN
cord-259603-bh198xgl	525	19	.	.	.
cord-259603-bh198xgl	526	1	In	in	IN
cord-259603-bh198xgl	526	2	addition	addition	NN
cord-259603-bh198xgl	526	3	to	to	IN
cord-259603-bh198xgl	526	4	promoting	promote	VBG
cord-259603-bh198xgl	526	5	mRNA	mrna	NN
cord-259603-bh198xgl	526	6	stability	stability	NN
cord-259603-bh198xgl	526	7	and	and	CC
cord-259603-bh198xgl	526	8	securing	secure	VBG
cord-259603-bh198xgl	526	9	their	-PRON-	PRP$
cord-259603-bh198xgl	526	10	recognition	recognition	NN
cord-259603-bh198xgl	526	11	by	by	IN
cord-259603-bh198xgl	526	12	host	host	NN
cord-259603-bh198xgl	526	13	cell	cell	NN
cord-259603-bh198xgl	526	14	ribosomes	ribosome	NNS
cord-259603-bh198xgl	526	15	,	,	,
cord-259603-bh198xgl	526	16	capping	cap	VBG
cord-259603-bh198xgl	526	17	of	of	IN
cord-259603-bh198xgl	526	18	viral	viral	JJ
cord-259603-bh198xgl	526	19	mRNAs	mRNAs	:
cord-259603-bh198xgl	526	20	also	also	RB
cord-259603-bh198xgl	526	21	promotes	promote	VBZ
cord-259603-bh198xgl	526	22	escape	escape	NN
cord-259603-bh198xgl	526	23	from	from	IN
cord-259603-bh198xgl	526	24	certain	certain	JJ
cord-259603-bh198xgl	526	25	antiviral	antiviral	JJ
cord-259603-bh198xgl	526	26	responses	response	NNS
cord-259603-bh198xgl	526	27	of	of	IN
cord-259603-bh198xgl	526	28	the	the	DT
cord-259603-bh198xgl	526	29	host	host	NN
cord-259603-bh198xgl	526	30	cell	cell	NN
cord-259603-bh198xgl	526	31	.	.	.
cord-259603-bh198xgl	527	1	The	the	DT
cord-259603-bh198xgl	527	2	retinoic	retinoic	JJ
cord-259603-bh198xgl	527	3	acidinducible	acidinducible	NNP
cord-259603-bh198xgl	527	4	gene	gene	NN
cord-259603-bh198xgl	527	5	1	1	CD
cord-259603-bh198xgl	527	6	and	and	CC
cord-259603-bh198xgl	527	7	melanoma	melanoma	NN
cord-259603-bh198xgl	527	8	differentiation	differentiation	NN
cord-259603-bh198xgl	527	9	-	-	HYPH
cord-259603-bh198xgl	527	10	associated	associate	VBN
cord-259603-bh198xgl	527	11	protein	protein	NN
cord-259603-bh198xgl	527	12	5	5	CD
cord-259603-bh198xgl	528	1	(	(	-LRB-
cord-259603-bh198xgl	528	2	Mda5	Mda5	NNP
cord-259603-bh198xgl	528	3	)	)	-RRB-
cord-259603-bh198xgl	528	4	were	be	VBD
cord-259603-bh198xgl	528	5	shown	show	VBN
cord-259603-bh198xgl	528	6	to	to	TO
cord-259603-bh198xgl	528	7	detect	detect	VB
cord-259603-bh198xgl	528	8	either	either	DT
cord-259603-bh198xgl	528	9	uncapped	uncapped	JJ
cord-259603-bh198xgl	528	10	triphosphorylated	triphosphorylate	VBN
cord-259603-bh198xgl	528	11	RNA	RNA	NNP
cord-259603-bh198xgl	528	12	or	or	CC
cord-259603-bh198xgl	528	13	cap-0-containing	cap-0-containing	NNP
cord-259603-bh198xgl	528	14	RNA	RNA	NNP
cord-259603-bh198xgl	528	15	(	(	-LRB-
cord-259603-bh198xgl	528	16	Devarkar	Devarkar	NNP
cord-259603-bh198xgl	528	17	et	et	FW
cord-259603-bh198xgl	528	18	al	al	NNP
cord-259603-bh198xgl	528	19	.	.	NNP
cord-259603-bh198xgl	528	20	,	,	,
cord-259603-bh198xgl	528	21	2016	2016	CD
cord-259603-bh198xgl	528	22	;	;	:
cord-259603-bh198xgl	528	23	Hyde	Hyde	NNP
cord-259603-bh198xgl	528	24	and	and	CC
cord-259603-bh198xgl	528	25	Diamond	Diamond	NNP
cord-259603-bh198xgl	528	26	,	,	,
cord-259603-bh198xgl	528	27	2015	2015	CD
cord-259603-bh198xgl	528	28	;	;	:
cord-259603-bh198xgl	528	29	Hyde	Hyde	NNP
cord-259603-bh198xgl	528	30	et	et	NNP
cord-259603-bh198xgl	528	31	al	al	NNP
cord-259603-bh198xgl	528	32	.	.	NNP
cord-259603-bh198xgl	528	33	,	,	,
cord-259603-bh198xgl	528	34	2014	2014	CD
cord-259603-bh198xgl	528	35	;	;	.
cord-259603-bh198xgl	529	1	Schuberth	Schuberth	NNP
cord-259603-bh198xgl	529	2	-	-	HYPH
cord-259603-bh198xgl	529	3	Wagner	Wagner	NNP
cord-259603-bh198xgl	529	4	et	et	NNP
cord-259603-bh198xgl	529	5	al	al	NNP
cord-259603-bh198xgl	529	6	.	.	.
cord-259603-bh198xgl	530	1	,	,	,
cord-259603-bh198xgl	530	2	2015	2015	CD
cord-259603-bh198xgl	530	3	;	;	:
cord-259603-bh198xgl	530	4	Z€	Z€	NNP
cord-259603-bh198xgl	530	5	ust	ust	NNP
cord-259603-bh198xgl	530	6	et	et	NNP
cord-259603-bh198xgl	530	7	al	al	NNP
cord-259603-bh198xgl	530	8	.	.	NNP
cord-259603-bh198xgl	530	9	,	,	,
cord-259603-bh198xgl	530	10	2011	2011	CD
cord-259603-bh198xgl	530	11	)	)	-RRB-
cord-259603-bh198xgl	530	12	,	,	,
cord-259603-bh198xgl	530	13	resulting	result	VBG
cord-259603-bh198xgl	530	14	in	in	IN
cord-259603-bh198xgl	530	15	the	the	DT
cord-259603-bh198xgl	530	16	expression	expression	NN
cord-259603-bh198xgl	530	17	of	of	IN
cord-259603-bh198xgl	530	18	antiviral	antiviral	JJ
cord-259603-bh198xgl	530	19	interferon	interferon	NN
cord-259603-bh198xgl	530	20	-	-	HYPH
cord-259603-bh198xgl	530	21	stimulated	stimulate	VBN
cord-259603-bh198xgl	530	22	genes	gene	NNS
cord-259603-bh198xgl	530	23	(	(	-LRB-
cord-259603-bh198xgl	530	24	ISGs	ISGs	NNP
cord-259603-bh198xgl	530	25	)	)	-RRB-
cord-259603-bh198xgl	530	26	in	in	IN
cord-259603-bh198xgl	530	27	infected	infected	JJ
cord-259603-bh198xgl	530	28	and	and	CC
cord-259603-bh198xgl	530	29	neighboring	neighboring	NN
cord-259603-bh198xgl	530	30	cells	cell	NNS
cord-259603-bh198xgl	530	31	.	.	.
cord-259603-bh198xgl	531	1	Interferon	interferon	NN
cord-259603-bh198xgl	531	2	-	-	HYPH
cord-259603-bh198xgl	531	3	induced	induce	VBN
cord-259603-bh198xgl	531	4	proteins	protein	NNS
cord-259603-bh198xgl	531	5	with	with	IN
cord-259603-bh198xgl	531	6	a	a	DT
cord-259603-bh198xgl	531	7	tetratricopeptide	tetratricopeptide	JJ
cord-259603-bh198xgl	531	8	repeat	repeat	NN
cord-259603-bh198xgl	531	9	1	1	CD
cord-259603-bh198xgl	532	1	(	(	-LRB-
cord-259603-bh198xgl	532	2	IFIT1/56	IFIT1/56	NNP
cord-259603-bh198xgl	532	3	)	)	-RRB-
cord-259603-bh198xgl	532	4	and	and	CC
cord-259603-bh198xgl	532	5	IFIT2/54	IFIT2/54	NNP
cord-259603-bh198xgl	532	6	(	(	-LRB-
cord-259603-bh198xgl	532	7	IFIT2	ifit2	NN
cord-259603-bh198xgl	532	8	)	)	-RRB-
cord-259603-bh198xgl	532	9	have	have	VBP
cord-259603-bh198xgl	532	10	been	be	VBN
cord-259603-bh198xgl	532	11	shown	show	VBN
cord-259603-bh198xgl	532	12	to	to	TO
cord-259603-bh198xgl	532	13	recognize	recognize	VB
cord-259603-bh198xgl	532	14	miscapped	miscapped	JJ
cord-259603-bh198xgl	532	15	RNAs	rna	NNS
cord-259603-bh198xgl	532	16	,	,	,
cord-259603-bh198xgl	532	17	in	in	IN
cord-259603-bh198xgl	532	18	order	order	NN
cord-259603-bh198xgl	532	19	to	to	TO
cord-259603-bh198xgl	532	20	restrict	restrict	VB
cord-259603-bh198xgl	532	21	viral	viral	JJ
cord-259603-bh198xgl	532	22	translation	translation	NN
cord-259603-bh198xgl	532	23	(	(	-LRB-
cord-259603-bh198xgl	532	24	Daffis	Daffis	NNP
cord-259603-bh198xgl	532	25	et	et	NNP
cord-259603-bh198xgl	532	26	al	al	NNP
cord-259603-bh198xgl	532	27	.	.	NNP
cord-259603-bh198xgl	532	28	,	,	,
cord-259603-bh198xgl	532	29	2010	2010	CD
cord-259603-bh198xgl	532	30	;	;	:
cord-259603-bh198xgl	532	31	Pichlmair	Pichlmair	NNP
cord-259603-bh198xgl	532	32	et	et	NNP
cord-259603-bh198xgl	532	33	al	al	NNP
cord-259603-bh198xgl	532	34	.	.	NNP
cord-259603-bh198xgl	532	35	,	,	,
cord-259603-bh198xgl	532	36	2011	2011	CD
cord-259603-bh198xgl	532	37	)	)	-RRB-
cord-259603-bh198xgl	532	38	.	.	.
cord-259603-bh198xgl	533	1	A	a	DT
cord-259603-bh198xgl	533	2	subsequent	subsequent	JJ
cord-259603-bh198xgl	533	3	study	study	NN
cord-259603-bh198xgl	533	4	identified	identify	VBN
cord-259603-bh198xgl	533	5	IFIT1	ifit1	RB
cord-259603-bh198xgl	533	6	as	as	IN
cord-259603-bh198xgl	533	7	the	the	DT
cord-259603-bh198xgl	533	8	only	only	JJ
cord-259603-bh198xgl	533	9	interferon	interferon	NN
cord-259603-bh198xgl	533	10	-	-	HYPH
cord-259603-bh198xgl	533	11	induced	induce	VBN
cord-259603-bh198xgl	533	12	protein	protein	NN
cord-259603-bh198xgl	533	13	whose	whose	WP$
cord-259603-bh198xgl	533	14	RNA	RNA	NNP
cord-259603-bh198xgl	533	15	-	-	HYPH
cord-259603-bh198xgl	533	16	binding	bind	VBG
cord-259603-bh198xgl	533	17	affinity	affinity	NN
cord-259603-bh198xgl	533	18	was	be	VBD
cord-259603-bh198xgl	533	19	affected	affect	VBN
cord-259603-bh198xgl	533	20	by	by	IN
cord-259603-bh198xgl	533	21	the	the	DT
cord-259603-bh198xgl	533	22	ribose-2	ribose-2	NNP
cord-259603-bh198xgl	533	23	0	0	CD
cord-259603-bh198xgl	533	24	-O	-o	ADD
cord-259603-bh198xgl	533	25	methylation	methylation	NN
cord-259603-bh198xgl	533	26	state	state	NN
cord-259603-bh198xgl	533	27	of	of	IN
cord-259603-bh198xgl	533	28	the	the	DT
cord-259603-bh198xgl	533	29	5	5	CD
cord-259603-bh198xgl	533	30	0	0	CD
cord-259603-bh198xgl	533	31	cap	cap	NN
cord-259603-bh198xgl	533	32	structure	structure	NN
cord-259603-bh198xgl	533	33	(	(	-LRB-
cord-259603-bh198xgl	533	34	cap-0	cap-0	NNP
cord-259603-bh198xgl	533	35	/	/	SYM
cord-259603-bh198xgl	533	36	cap-1	cap-1	NNP
cord-259603-bh198xgl	533	37	)	)	-RRB-
cord-259603-bh198xgl	533	38	.	.	.
cord-259603-bh198xgl	534	1	The	the	DT
cord-259603-bh198xgl	534	2	data	datum	NNS
cord-259603-bh198xgl	534	3	support	support	VBP
cord-259603-bh198xgl	534	4	a	a	DT
cord-259603-bh198xgl	534	5	model	model	NN
cord-259603-bh198xgl	534	6	in	in	IN
cord-259603-bh198xgl	534	7	which	which	WDT
cord-259603-bh198xgl	534	8	IFIT1	ifit1	VBP
cord-259603-bh198xgl	534	9	efficiently	efficiently	RB
cord-259603-bh198xgl	534	10	binds	bind	VBZ
cord-259603-bh198xgl	534	11	and	and	CC
cord-259603-bh198xgl	534	12	sequesters	sequester	VBZ
cord-259603-bh198xgl	534	13	capped	cap	VBN
cord-259603-bh198xgl	534	14	mRNA	mrna	NN
cord-259603-bh198xgl	534	15	that	that	WDT
cord-259603-bh198xgl	534	16	lacks	lack	VBZ
cord-259603-bh198xgl	534	17	a	a	DT
cord-259603-bh198xgl	534	18	ribose-2	ribose-2	NNP
cord-259603-bh198xgl	534	19	0	0	CD
cord-259603-bh198xgl	534	20	-O	-O	:
cord-259603-bh198xgl	534	21	-	-	HYPH
cord-259603-bh198xgl	534	22	methyl	methyl	JJ
cord-259603-bh198xgl	534	23	group	group	NN
cord-259603-bh198xgl	534	24	.	.	.
cord-259603-bh198xgl	535	1	Consistent	consistent	JJ
cord-259603-bh198xgl	535	2	with	with	IN
cord-259603-bh198xgl	535	3	this	this	DT
cord-259603-bh198xgl	535	4	,	,	,
cord-259603-bh198xgl	535	5	viral	viral	JJ
cord-259603-bh198xgl	535	6	mRNA	mRNA	NNP
cord-259603-bh198xgl	535	7	translation	translation	NN
cord-259603-bh198xgl	535	8	was	be	VBD
cord-259603-bh198xgl	535	9	shown	show	VBN
cord-259603-bh198xgl	535	10	to	to	TO
cord-259603-bh198xgl	535	11	be	be	VB
cord-259603-bh198xgl	535	12	reduced	reduce	VBN
cord-259603-bh198xgl	535	13	in	in	IN
cord-259603-bh198xgl	535	14	cells	cell	NNS
cord-259603-bh198xgl	535	15	infected	infect	VBN
cord-259603-bh198xgl	535	16	with	with	IN
cord-259603-bh198xgl	535	17	2	2	CD
cord-259603-bh198xgl	535	18	0	0	CD
cord-259603-bh198xgl	535	19	-O	-o	CD
cord-259603-bh198xgl	535	20	-	-	HYPH
cord-259603-bh198xgl	535	21	MTase	mtase	NN
cord-259603-bh198xgl	535	22	-	-	HYPH
cord-259603-bh198xgl	535	23	deficient	deficient	JJ
cord-259603-bh198xgl	535	24	CoVs	covs	NN
cord-259603-bh198xgl	535	25	(	(	-LRB-
cord-259603-bh198xgl	535	26	Habjan	Habjan	NNP
cord-259603-bh198xgl	535	27	et	et	NNP
cord-259603-bh198xgl	535	28	al	al	NNP
cord-259603-bh198xgl	535	29	.	.	NNP
cord-259603-bh198xgl	535	30	,	,	,
cord-259603-bh198xgl	535	31	2013	2013	CD
cord-259603-bh198xgl	535	32	)	)	-RRB-
cord-259603-bh198xgl	535	33	.	.	.
cord-259603-bh198xgl	536	1	Other	other	JJ
cord-259603-bh198xgl	536	2	studies	study	NNS
cord-259603-bh198xgl	536	3	suggested	suggest	VBD
cord-259603-bh198xgl	536	4	that	that	IN
cord-259603-bh198xgl	536	5	2	2	CD
cord-259603-bh198xgl	536	6	0	0	CD
cord-259603-bh198xgl	536	7	-O	-O	:
cord-259603-bh198xgl	536	8	methylation	methylation	NN
cord-259603-bh198xgl	536	9	of	of	IN
cord-259603-bh198xgl	536	10	cap	cap	NN
cord-259603-bh198xgl	536	11	structures	structure	NNS
cord-259603-bh198xgl	536	12	prevents	prevent	VBZ
cord-259603-bh198xgl	536	13	or	or	CC
cord-259603-bh198xgl	536	14	delays	delay	VBZ
cord-259603-bh198xgl	536	15	the	the	DT
cord-259603-bh198xgl	536	16	Mda5-dependent	Mda5-dependent	NNP
cord-259603-bh198xgl	536	17	recognition	recognition	NN
cord-259603-bh198xgl	536	18	of	of	IN
cord-259603-bh198xgl	536	19	viral	viral	JJ
cord-259603-bh198xgl	536	20	mRNAs	mRNAs	NNPS
cord-259603-bh198xgl	536	21	as	as	IN
cord-259603-bh198xgl	536	22	"	"	``
cord-259603-bh198xgl	536	23	nonself	nonself	NNP
cord-259603-bh198xgl	536	24	.	.	.
cord-259603-bh198xgl	536	25	"	"	''
cord-259603-bh198xgl	537	1	This	this	DT
cord-259603-bh198xgl	537	2	mRNA	mrna	NN
cord-259603-bh198xgl	537	3	cap	cap	NN
cord-259603-bh198xgl	537	4	modification	modification	NN
cord-259603-bh198xgl	537	5	thus	thus	RB
cord-259603-bh198xgl	537	6	limits	limit	VBZ
cord-259603-bh198xgl	537	7	the	the	DT
cord-259603-bh198xgl	537	8	antiviral	antiviral	JJ
cord-259603-bh198xgl	537	9	response	response	NN
cord-259603-bh198xgl	537	10	launched	launch	VBN
cord-259603-bh198xgl	537	11	upon	upon	IN
cord-259603-bh198xgl	537	12	infection	infection	NN
cord-259603-bh198xgl	537	13	,	,	,
cord-259603-bh198xgl	537	14	thereby	thereby	RB
cord-259603-bh198xgl	537	15	affecting	affect	VBG
cord-259603-bh198xgl	537	16	viral	viral	JJ
cord-259603-bh198xgl	537	17	pathogenesis	pathogenesis	NN
cord-259603-bh198xgl	537	18	(	(	-LRB-
cord-259603-bh198xgl	537	19	Daffis	Daffis	NNP
cord-259603-bh198xgl	537	20	et	et	NNP
cord-259603-bh198xgl	537	21	al	al	NNP
cord-259603-bh198xgl	537	22	.	.	NNP
cord-259603-bh198xgl	537	23	,	,	,
cord-259603-bh198xgl	537	24	2010	2010	CD
cord-259603-bh198xgl	537	25	;	;	.
cord-259603-bh198xgl	538	1	Schuberth	Schuberth	NNP
cord-259603-bh198xgl	538	2	-	-	HYPH
cord-259603-bh198xgl	538	3	Wagner	Wagner	NNP
cord-259603-bh198xgl	538	4	et	et	NNP
cord-259603-bh198xgl	538	5	al	al	NNP
cord-259603-bh198xgl	538	6	.	.	.
cord-259603-bh198xgl	539	1	,	,	,
cord-259603-bh198xgl	539	2	2015	2015	CD
cord-259603-bh198xgl	539	3	;	;	:
cord-259603-bh198xgl	539	4	Z€	Z€	NNP
cord-259603-bh198xgl	539	5	ust	ust	NNP
cord-259603-bh198xgl	539	6	et	et	NNP
cord-259603-bh198xgl	539	7	al	al	NNP
cord-259603-bh198xgl	539	8	.	.	NNP
cord-259603-bh198xgl	539	9	,	,	,
cord-259603-bh198xgl	539	10	2011	2011	CD
cord-259603-bh198xgl	539	11	)	)	-RRB-
cord-259603-bh198xgl	539	12	.	.	.
cord-259603-bh198xgl	540	1	The	the	DT
cord-259603-bh198xgl	540	2	genomic	genomic	NN
cord-259603-bh198xgl	540	3	and	and	CC
cord-259603-bh198xgl	540	4	sg	sg	NNP
cord-259603-bh198xgl	540	5	mRNAs	mRNAs	NNP
cord-259603-bh198xgl	540	6	of	of	IN
cord-259603-bh198xgl	540	7	nidoviruses	nidoviruse	NNS
cord-259603-bh198xgl	540	8	are	be	VBP
cord-259603-bh198xgl	540	9	presumed	presume	VBN
cord-259603-bh198xgl	540	10	to	to	TO
cord-259603-bh198xgl	540	11	be	be	VB
cord-259603-bh198xgl	540	12	capped	cap	VBN
cord-259603-bh198xgl	540	13	at	at	IN
cord-259603-bh198xgl	540	14	their	-PRON-	PRP$
cord-259603-bh198xgl	540	15	5	5	CD
cord-259603-bh198xgl	540	16	0	0	CD
cord-259603-bh198xgl	540	17	end	end	NN
cord-259603-bh198xgl	540	18	and	and	CC
cord-259603-bh198xgl	540	19	polyadenylated	polyadenylate	VBN
cord-259603-bh198xgl	540	20	at	at	IN
cord-259603-bh198xgl	540	21	their	-PRON-	PRP$
cord-259603-bh198xgl	540	22	3	3	CD
cord-259603-bh198xgl	540	23	0	0	CD
cord-259603-bh198xgl	540	24	end	end	NN
cord-259603-bh198xgl	541	1	(	(	-LRB-
cord-259603-bh198xgl	541	2	Fig	Fig	NNP
cord-259603-bh198xgl	541	3	.	.	NNP
cord-259603-bh198xgl	541	4	1	1	CD
cord-259603-bh198xgl	541	5	)	)	-RRB-
cord-259603-bh198xgl	541	6	.	.	.
cord-259603-bh198xgl	542	1	The	the	DT
cord-259603-bh198xgl	542	2	presence	presence	NN
cord-259603-bh198xgl	542	3	of	of	IN
cord-259603-bh198xgl	542	4	a	a	DT
cord-259603-bh198xgl	542	5	cap	cap	NN
cord-259603-bh198xgl	542	6	structure	structure	NN
cord-259603-bh198xgl	542	7	was	be	VBD
cord-259603-bh198xgl	542	8	first	first	RB
cord-259603-bh198xgl	542	9	suggested	suggest	VBN
cord-259603-bh198xgl	542	10	based	base	VBN
cord-259603-bh198xgl	542	11	on	on	IN
cord-259603-bh198xgl	542	12	studies	study	NNS
cord-259603-bh198xgl	542	13	using	use	VBG
cord-259603-bh198xgl	542	14	32	32	CD
cord-259603-bh198xgl	542	15	P	p	NN
cord-259603-bh198xgl	542	16	-	-	HYPH
cord-259603-bh198xgl	542	17	labeled	label	VBN
cord-259603-bh198xgl	542	18	MHV	MHV	NNP
cord-259603-bh198xgl	542	19	RNA	RNA	NNP
cord-259603-bh198xgl	542	20	that	that	WDT
cord-259603-bh198xgl	542	21	was	be	VBD
cord-259603-bh198xgl	542	22	digested	digest	VBN
cord-259603-bh198xgl	542	23	with	with	IN
cord-259603-bh198xgl	542	24	RNase	RNase	NNP
cord-259603-bh198xgl	542	25	T1	T1	NNP
cord-259603-bh198xgl	542	26	and	and	CC
cord-259603-bh198xgl	542	27	T2	T2	NNP
cord-259603-bh198xgl	542	28	and	and	CC
cord-259603-bh198xgl	542	29	subjected	subject	VBN
cord-259603-bh198xgl	542	30	to	to	IN
cord-259603-bh198xgl	542	31	DEAEcellulose	deaecellulose	VB
cord-259603-bh198xgl	542	32	chromatography	chromatography	NN
cord-259603-bh198xgl	542	33	(	(	-LRB-
cord-259603-bh198xgl	542	34	Lai	Lai	NNP
cord-259603-bh198xgl	542	35	and	and	CC
cord-259603-bh198xgl	542	36	Stohlman	Stohlman	NNP
cord-259603-bh198xgl	542	37	,	,	,
cord-259603-bh198xgl	542	38	1981	1981	CD
cord-259603-bh198xgl	542	39	)	)	-RRB-
cord-259603-bh198xgl	542	40	.	.	.
cord-259603-bh198xgl	543	1	The	the	DT
cord-259603-bh198xgl	543	2	presence	presence	NN
cord-259603-bh198xgl	543	3	of	of	IN
cord-259603-bh198xgl	543	4	a	a	DT
cord-259603-bh198xgl	543	5	cap	cap	NN
cord-259603-bh198xgl	543	6	was	be	VBD
cord-259603-bh198xgl	543	7	further	further	RB
cord-259603-bh198xgl	543	8	substantiated	substantiate	VBN
cord-259603-bh198xgl	543	9	by	by	IN
cord-259603-bh198xgl	543	10	immunoprecipitation	immunoprecipitation	NN
cord-259603-bh198xgl	543	11	experiments	experiment	NNS
cord-259603-bh198xgl	543	12	using	use	VBG
cord-259603-bh198xgl	543	13	a	a	DT
cord-259603-bh198xgl	543	14	cap	cap	NN
cord-259603-bh198xgl	543	15	-	-	HYPH
cord-259603-bh198xgl	543	16	specific	specific	JJ
cord-259603-bh198xgl	543	17	monoclonal	monoclonal	JJ
cord-259603-bh198xgl	543	18	antibody	antibody	NN
cord-259603-bh198xgl	543	19	that	that	WDT
cord-259603-bh198xgl	543	20	was	be	VBD
cord-259603-bh198xgl	543	21	shown	show	VBN
cord-259603-bh198xgl	543	22	to	to	TO
cord-259603-bh198xgl	543	23	specifically	specifically	RB
cord-259603-bh198xgl	543	24	bind	bind	VB
cord-259603-bh198xgl	543	25	to	to	IN
cord-259603-bh198xgl	543	26	equine	equine	JJ
cord-259603-bh198xgl	543	27	torovirus	torovirus	NN
cord-259603-bh198xgl	544	1	mRNAs	mRNAs	.
cord-259603-bh198xgl	545	1	(	(	-LRB-
cord-259603-bh198xgl	545	2	van	van	NNP
cord-259603-bh198xgl	545	3	Vliet	Vliet	NNP
cord-259603-bh198xgl	545	4	et	et	NNP
cord-259603-bh198xgl	545	5	al	al	NNP
cord-259603-bh198xgl	545	6	.	.	NNP
cord-259603-bh198xgl	545	7	,	,	,
cord-259603-bh198xgl	545	8	2002	2002	CD
cord-259603-bh198xgl	545	9	)	)	-RRB-
cord-259603-bh198xgl	545	10	.	.	.
cord-259603-bh198xgl	546	1	Although	although	IN
cord-259603-bh198xgl	546	2	the	the	DT
cord-259603-bh198xgl	546	3	(	(	-LRB-
cord-259603-bh198xgl	546	4	presumed	presumed	JJ
cord-259603-bh198xgl	546	5	)	)	-RRB-
cord-259603-bh198xgl	546	6	capping	cap	VBG
cord-259603-bh198xgl	546	7	machinery	machinery	NN
cord-259603-bh198xgl	546	8	of	of	IN
cord-259603-bh198xgl	546	9	arteriviruses	arteriviruse	NNS
cord-259603-bh198xgl	546	10	has	have	VBZ
cord-259603-bh198xgl	546	11	remained	remain	VBN
cord-259603-bh198xgl	546	12	essentially	essentially	RB
cord-259603-bh198xgl	546	13	uncharacterized	uncharacterized	JJ
cord-259603-bh198xgl	546	14	thus	thus	RB
cord-259603-bh198xgl	546	15	far	far	RB
cord-259603-bh198xgl	547	1	(	(	-LRB-
cord-259603-bh198xgl	547	2	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	547	3	et	et	NNP
cord-259603-bh198xgl	547	4	al	al	NNP
cord-259603-bh198xgl	547	5	.	.	NNP
cord-259603-bh198xgl	547	6	,	,	,
cord-259603-bh198xgl	547	7	2015b	2015b	CD
cord-259603-bh198xgl	547	8	)	)	-RRB-
cord-259603-bh198xgl	547	9	,	,	,
cord-259603-bh198xgl	547	10	three	three	CD
cord-259603-bh198xgl	547	11	conserved	conserved	JJ
cord-259603-bh198xgl	547	12	putative	putative	JJ
cord-259603-bh198xgl	547	13	capping	cap	VBG
cord-259603-bh198xgl	547	14	enzymes	enzyme	NNS
cord-259603-bh198xgl	547	15	were	be	VBD
cord-259603-bh198xgl	547	16	identified	identify	VBN
cord-259603-bh198xgl	547	17	in	in	IN
cord-259603-bh198xgl	547	18	the	the	DT
cord-259603-bh198xgl	547	19	conserved	conserve	VBN
cord-259603-bh198xgl	547	20	ORF1b	ORF1b	NNP
cord-259603-bh198xgl	547	21	-	-	HYPH
cord-259603-bh198xgl	547	22	encoded	encode	VBN
cord-259603-bh198xgl	547	23	part	part	NN
cord-259603-bh198xgl	547	24	of	of	IN
cord-259603-bh198xgl	547	25	the	the	DT
cord-259603-bh198xgl	547	26	replicase	replicase	NN
cord-259603-bh198xgl	547	27	of	of	IN
cord-259603-bh198xgl	547	28	Coronaviridae	Coronaviridae	NNP
cord-259603-bh198xgl	547	29	,	,	,
cord-259603-bh198xgl	547	30	Roniviridae	Roniviridae	NNP
cord-259603-bh198xgl	547	31	,	,	,
cord-259603-bh198xgl	547	32	and	and	CC
cord-259603-bh198xgl	547	33	Mesoniviridae	Mesoniviridae	NNP
cord-259603-bh198xgl	547	34	,	,	,
cord-259603-bh198xgl	547	35	which	which	WDT
cord-259603-bh198xgl	547	36	all	all	DT
cord-259603-bh198xgl	547	37	have	have	VBP
cord-259603-bh198xgl	547	38	substantially	substantially	RB
cord-259603-bh198xgl	547	39	larger	large	JJR
cord-259603-bh198xgl	547	40	genomes	genome	NNS
cord-259603-bh198xgl	547	41	.	.	.
cord-259603-bh198xgl	548	1	These	these	DT
cord-259603-bh198xgl	548	2	enzymatic	enzymatic	JJ
cord-259603-bh198xgl	548	3	activities	activity	NNS
cord-259603-bh198xgl	548	4	,	,	,
cord-259603-bh198xgl	548	5	which	which	WDT
cord-259603-bh198xgl	548	6	were	be	VBD
cord-259603-bh198xgl	548	7	proposed	propose	VBN
cord-259603-bh198xgl	548	8	to	to	TO
cord-259603-bh198xgl	548	9	participate	participate	VB
cord-259603-bh198xgl	548	10	in	in	IN
cord-259603-bh198xgl	548	11	the	the	DT
cord-259603-bh198xgl	548	12	synthesis	synthesis	NN
cord-259603-bh198xgl	548	13	of	of	IN
cord-259603-bh198xgl	548	14	a	a	DT
cord-259603-bh198xgl	548	15	cap-1	cap-1	NNP
cord-259603-bh198xgl	548	16	structure	structure	NN
cord-259603-bh198xgl	548	17	(	(	-LRB-
cord-259603-bh198xgl	548	18	N7	N7	NNP
cord-259603-bh198xgl	548	19	m	m	NNP
cord-259603-bh198xgl	548	20	GpppN	GpppN	NNP
cord-259603-bh198xgl	548	21	2	2	CD
cord-259603-bh198xgl	548	22	0	0	CD
cord-259603-bh198xgl	548	23	Om	Om	NNP
cord-259603-bh198xgl	548	24	)	)	-RRB-
cord-259603-bh198xgl	548	25	,	,	,
cord-259603-bh198xgl	548	26	are	be	VBP
cord-259603-bh198xgl	548	27	the	the	DT
cord-259603-bh198xgl	548	28	following	follow	VBG
cord-259603-bh198xgl	548	29	:	:	:
cord-259603-bh198xgl	548	30	(	(	-LRB-
cord-259603-bh198xgl	548	31	i	i	NN
cord-259603-bh198xgl	548	32	)	)	-RRB-
cord-259603-bh198xgl	549	1	the	the	DT
cord-259603-bh198xgl	549	2	nsp13	nsp13	CD
cord-259603-bh198xgl	549	3	helicase/	helicase/	CD
cord-259603-bh198xgl	550	1	RTPase	RTPase	NNP
cord-259603-bh198xgl	551	1	(	(	-LRB-
cord-259603-bh198xgl	551	2	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	551	3	and	and	CC
cord-259603-bh198xgl	551	4	Ziebuhr	Ziebuhr	NNP
cord-259603-bh198xgl	551	5	,	,	,
cord-259603-bh198xgl	551	6	2004	2004	CD
cord-259603-bh198xgl	551	7	)	)	-RRB-
cord-259603-bh198xgl	551	8	,	,	,
cord-259603-bh198xgl	551	9	(	(	-LRB-
cord-259603-bh198xgl	551	10	ii	ii	NN
cord-259603-bh198xgl	551	11	)	)	-RRB-
cord-259603-bh198xgl	552	1	the	the	DT
cord-259603-bh198xgl	552	2	nsp14	nsp14	XX
cord-259603-bh198xgl	552	3	N7-MTase	n7-mtase	NN
cord-259603-bh198xgl	553	1	(	(	-LRB-
cord-259603-bh198xgl	553	2	Chen	Chen	NNP
cord-259603-bh198xgl	553	3	et	et	NNP
cord-259603-bh198xgl	553	4	al	al	NNP
cord-259603-bh198xgl	553	5	.	.	NNP
cord-259603-bh198xgl	553	6	,	,	,
cord-259603-bh198xgl	553	7	2009c	2009c	CD
cord-259603-bh198xgl	553	8	;	;	:
cord-259603-bh198xgl	554	1	Ma	Ma	NNP
cord-259603-bh198xgl	554	2	et	et	NNP
cord-259603-bh198xgl	554	3	al	al	NNP
cord-259603-bh198xgl	554	4	.	.	NNP
cord-259603-bh198xgl	554	5	,	,	,
cord-259603-bh198xgl	554	6	2015	2015	CD
cord-259603-bh198xgl	554	7	)	)	-RRB-
cord-259603-bh198xgl	554	8	,	,	,
cord-259603-bh198xgl	554	9	and	and	CC
cord-259603-bh198xgl	554	10	(	(	-LRB-
cord-259603-bh198xgl	554	11	iii	iii	NN
cord-259603-bh198xgl	554	12	)	)	-RRB-
cord-259603-bh198xgl	555	1	the	the	DT
cord-259603-bh198xgl	555	2	nsp16	nsp16	NNS
cord-259603-bh198xgl	555	3	2	2	CD
cord-259603-bh198xgl	555	4	0	0	CD
cord-259603-bh198xgl	555	5	-O	-o	CD
cord-259603-bh198xgl	555	6	-	-	HYPH
cord-259603-bh198xgl	555	7	MTase	MTase	NNP
cord-259603-bh198xgl	555	8	(	(	-LRB-
cord-259603-bh198xgl	555	9	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	555	10	et	et	NNP
cord-259603-bh198xgl	555	11	al	al	NNP
cord-259603-bh198xgl	555	12	.	.	NNP
cord-259603-bh198xgl	555	13	,	,	,
cord-259603-bh198xgl	555	14	2010	2010	CD
cord-259603-bh198xgl	555	15	;	;	:
cord-259603-bh198xgl	555	16	Decroly	Decroly	NNP
cord-259603-bh198xgl	555	17	et	et	NNP
cord-259603-bh198xgl	555	18	al	al	NNP
cord-259603-bh198xgl	555	19	.	.	NNP
cord-259603-bh198xgl	555	20	,	,	,
cord-259603-bh198xgl	555	21	2008	2008	CD
cord-259603-bh198xgl	555	22	;	;	:
cord-259603-bh198xgl	555	23	Snijder	Snijder	NNP
cord-259603-bh198xgl	555	24	et	et	NNP
cord-259603-bh198xgl	555	25	al	al	NNP
cord-259603-bh198xgl	555	26	.	.	NNP
cord-259603-bh198xgl	555	27	,	,	,
cord-259603-bh198xgl	555	28	2003	2003	CD
cord-259603-bh198xgl	556	1	;	;	:
cord-259603-bh198xgl	556	2	von	von	NNP
cord-259603-bh198xgl	556	3	Grotthuss	Grotthuss	NNP
cord-259603-bh198xgl	556	4	et	et	FW
cord-259603-bh198xgl	556	5	al	al	NNP
cord-259603-bh198xgl	556	6	.	.	NNP
cord-259603-bh198xgl	556	7	,	,	,
cord-259603-bh198xgl	556	8	2003	2003	CD
cord-259603-bh198xgl	556	9	;	;	:
cord-259603-bh198xgl	556	10	Zeng	Zeng	NNP
cord-259603-bh198xgl	556	11	et	et	FW
cord-259603-bh198xgl	556	12	al	al	NNP
cord-259603-bh198xgl	556	13	.	.	NNP
cord-259603-bh198xgl	556	14	,	,	,
cord-259603-bh198xgl	556	15	2016	2016	CD
cord-259603-bh198xgl	556	16	)	)	-RRB-
cord-259603-bh198xgl	556	17	.	.	.
cord-259603-bh198xgl	557	1	At	at	IN
cord-259603-bh198xgl	557	2	present	present	JJ
cord-259603-bh198xgl	557	3	,	,	,
cord-259603-bh198xgl	557	4	structural	structural	JJ
cord-259603-bh198xgl	557	5	and	and	CC
cord-259603-bh198xgl	557	6	functional	functional	JJ
cord-259603-bh198xgl	557	7	studies	study	NNS
cord-259603-bh198xgl	557	8	,	,	,
cord-259603-bh198xgl	557	9	which	which	WDT
cord-259603-bh198xgl	557	10	were	be	VBD
cord-259603-bh198xgl	557	11	mainly	mainly	RB
cord-259603-bh198xgl	557	12	performed	perform	VBN
cord-259603-bh198xgl	557	13	with	with	IN
cord-259603-bh198xgl	557	14	purified	purify	VBN
cord-259603-bh198xgl	557	15	recombinant	recombinant	JJ
cord-259603-bh198xgl	557	16	SARS	SARS	NNP
cord-259603-bh198xgl	557	17	-	-	HYPH
cord-259603-bh198xgl	557	18	CoV	CoV	NNP
cord-259603-bh198xgl	557	19	nsps	nsps	NNP
cord-259603-bh198xgl	557	20	,	,	,
cord-259603-bh198xgl	557	21	suggest	suggest	VBP
cord-259603-bh198xgl	557	22	that	that	IN
cord-259603-bh198xgl	557	23	CoVs	CoVs	NNP
cord-259603-bh198xgl	557	24	follow	follow	VB
cord-259603-bh198xgl	557	25	a	a	DT
cord-259603-bh198xgl	557	26	capping	cap	VBG
cord-259603-bh198xgl	557	27	pathway	pathway	NN
cord-259603-bh198xgl	557	28	that	that	WDT
cord-259603-bh198xgl	557	29	is	be	VBZ
cord-259603-bh198xgl	557	30	very	very	RB
cord-259603-bh198xgl	557	31	similar	similar	JJ
cord-259603-bh198xgl	557	32	to	to	IN
cord-259603-bh198xgl	557	33	that	that	DT
cord-259603-bh198xgl	557	34	of	of	IN
cord-259603-bh198xgl	557	35	eukaryotic	eukaryotic	JJ
cord-259603-bh198xgl	557	36	cells	cell	NNS
cord-259603-bh198xgl	557	37	.	.	.
cord-259603-bh198xgl	558	1	Cap	Cap	NNP
cord-259603-bh198xgl	558	2	synthesis	synthesis	NN
cord-259603-bh198xgl	558	3	is	be	VBZ
cord-259603-bh198xgl	558	4	presumed	presume	VBN
cord-259603-bh198xgl	558	5	to	to	TO
cord-259603-bh198xgl	558	6	start	start	VB
cord-259603-bh198xgl	558	7	by	by	IN
cord-259603-bh198xgl	558	8	hydrolysis	hydrolysis	NN
cord-259603-bh198xgl	558	9	of	of	IN
cord-259603-bh198xgl	558	10	the	the	DT
cord-259603-bh198xgl	558	11	5	5	CD
cord-259603-bh198xgl	558	12	0	0	CD
cord-259603-bh198xgl	558	13	end	end	NN
cord-259603-bh198xgl	558	14	of	of	IN
cord-259603-bh198xgl	558	15	a	a	DT
cord-259603-bh198xgl	558	16	nascent	nascent	JJ
cord-259603-bh198xgl	558	17	RNA	RNA	NNP
cord-259603-bh198xgl	558	18	by	by	IN
cord-259603-bh198xgl	558	19	the	the	DT
cord-259603-bh198xgl	558	20	RTPase	RTPase	NNP
cord-259603-bh198xgl	558	21	function	function	NN
cord-259603-bh198xgl	558	22	of	of	IN
cord-259603-bh198xgl	558	23	nsp13	nsp13	ADD
cord-259603-bh198xgl	558	24	to	to	TO
cord-259603-bh198xgl	558	25	yield	yield	VB
cord-259603-bh198xgl	558	26	pp	pp	NNP
cord-259603-bh198xgl	558	27	-	-	HYPH
cord-259603-bh198xgl	558	28	RNA	RNA	NNP
cord-259603-bh198xgl	558	29	(	(	-LRB-
cord-259603-bh198xgl	558	30	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	558	31	and	and	CC
cord-259603-bh198xgl	558	32	Ziebuhr	Ziebuhr	NNP
cord-259603-bh198xgl	558	33	,	,	,
cord-259603-bh198xgl	558	34	2004	2004	CD
cord-259603-bh198xgl	558	35	)	)	-RRB-
cord-259603-bh198xgl	558	36	.	.	.
cord-259603-bh198xgl	559	1	Then	then	RB
cord-259603-bh198xgl	559	2	,	,	,
cord-259603-bh198xgl	559	3	a	a	DT
cord-259603-bh198xgl	559	4	still	still	RB
cord-259603-bh198xgl	559	5	elusive	elusive	JJ
cord-259603-bh198xgl	559	6	GTase	GTase	NNP
cord-259603-bh198xgl	559	7	must	must	MD
cord-259603-bh198xgl	559	8	transfer	transfer	VB
cord-259603-bh198xgl	559	9	a	a	DT
cord-259603-bh198xgl	559	10	GMP	GMP	NNP
cord-259603-bh198xgl	559	11	molecule	molecule	NN
cord-259603-bh198xgl	559	12	onto	onto	IN
cord-259603-bh198xgl	559	13	the	the	DT
cord-259603-bh198xgl	559	14	pp	pp	NNP
cord-259603-bh198xgl	559	15	-	-	HYPH
cord-259603-bh198xgl	559	16	RNA	RNA	NNP
cord-259603-bh198xgl	559	17	to	to	TO
cord-259603-bh198xgl	559	18	yield	yield	VB
cord-259603-bh198xgl	559	19	Gppp	Gppp	NNP
cord-259603-bh198xgl	559	20	-	-	HYPH
cord-259603-bh198xgl	559	21	RNA	RNA	NNP
cord-259603-bh198xgl	559	22	.	.	.
cord-259603-bh198xgl	560	1	The	the	DT
cord-259603-bh198xgl	560	2	cap	cap	NN
cord-259603-bh198xgl	560	3	structure	structure	NN
cord-259603-bh198xgl	560	4	is	be	VBZ
cord-259603-bh198xgl	560	5	then	then	RB
cord-259603-bh198xgl	560	6	methylated	methylate	VBN
cord-259603-bh198xgl	560	7	at	at	IN
cord-259603-bh198xgl	560	8	the	the	DT
cord-259603-bh198xgl	560	9	N7	N7	NNP
cord-259603-bh198xgl	560	10	position	position	NN
cord-259603-bh198xgl	560	11	by	by	IN
cord-259603-bh198xgl	560	12	the	the	DT
cord-259603-bh198xgl	560	13	N7-MTase	N7-MTase	NNP
cord-259603-bh198xgl	560	14	domain	domain	NN
cord-259603-bh198xgl	560	15	of	of	IN
cord-259603-bh198xgl	560	16	the	the	DT
cord-259603-bh198xgl	560	17	bifunctional	bifunctional	JJ
cord-259603-bh198xgl	560	18	nsp14	nsp14	XX
cord-259603-bh198xgl	561	1	(	(	-LRB-
cord-259603-bh198xgl	561	2	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	561	3	et	et	NNP
cord-259603-bh198xgl	561	4	al	al	NNP
cord-259603-bh198xgl	561	5	.	.	NNP
cord-259603-bh198xgl	561	6	,	,	,
cord-259603-bh198xgl	561	7	2010	2010	CD
cord-259603-bh198xgl	561	8	;	;	:
cord-259603-bh198xgl	561	9	Chen	Chen	NNP
cord-259603-bh198xgl	561	10	et	et	NNP
cord-259603-bh198xgl	561	11	al	al	NNP
cord-259603-bh198xgl	561	12	.	.	.
cord-259603-bh198xgl	562	1	,	,	,
cord-259603-bh198xgl	562	2	2009c	2009c	CD
cord-259603-bh198xgl	562	3	)	)	-RRB-
cord-259603-bh198xgl	562	4	.	.	.
cord-259603-bh198xgl	563	1	Cap	cap	NN
cord-259603-bh198xgl	563	2	modification	modification	NN
cord-259603-bh198xgl	563	3	is	be	VBZ
cord-259603-bh198xgl	563	4	completed	complete	VBN
cord-259603-bh198xgl	563	5	by	by	IN
cord-259603-bh198xgl	563	6	the	the	DT
cord-259603-bh198xgl	563	7	conversion	conversion	NN
cord-259603-bh198xgl	563	8	of	of	IN
cord-259603-bh198xgl	563	9	the	the	DT
cord-259603-bh198xgl	563	10	cap-0	cap-0	NN
cord-259603-bh198xgl	563	11	into	into	IN
cord-259603-bh198xgl	563	12	a	a	DT
cord-259603-bh198xgl	563	13	cap-1	cap-1	NNP
cord-259603-bh198xgl	563	14	structure	structure	NN
cord-259603-bh198xgl	563	15	,	,	,
cord-259603-bh198xgl	563	16	which	which	WDT
cord-259603-bh198xgl	563	17	involves	involve	VBZ
cord-259603-bh198xgl	563	18	the	the	DT
cord-259603-bh198xgl	563	19	nsp10	nsp10	NNPS
cord-259603-bh198xgl	563	20	/	/	SYM
cord-259603-bh198xgl	563	21	nsp16	nsp16	NNS
cord-259603-bh198xgl	563	22	complex	complex	JJ
cord-259603-bh198xgl	563	23	(	(	-LRB-
cord-259603-bh198xgl	563	24	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	563	25	et	et	NNP
cord-259603-bh198xgl	563	26	al	al	NNP
cord-259603-bh198xgl	563	27	.	.	NNP
cord-259603-bh198xgl	563	28	,	,	,
cord-259603-bh198xgl	563	29	2010	2010	CD
cord-259603-bh198xgl	563	30	;	;	:
cord-259603-bh198xgl	563	31	Chen	Chen	NNP
cord-259603-bh198xgl	563	32	et	et	NNP
cord-259603-bh198xgl	563	33	al	al	NNP
cord-259603-bh198xgl	563	34	.	.	.
cord-259603-bh198xgl	564	1	,	,	,
cord-259603-bh198xgl	564	2	2009c	2009c	CD
cord-259603-bh198xgl	564	3	)	)	-RRB-
cord-259603-bh198xgl	565	1	in	in	IN
cord-259603-bh198xgl	565	2	which	which	WDT
cord-259603-bh198xgl	565	3	nsp16	nsp16	NNS
cord-259603-bh198xgl	565	4	possesses	possess	VBZ
cord-259603-bh198xgl	565	5	2	2	CD
cord-259603-bh198xgl	565	6	0	0	CD
cord-259603-bh198xgl	565	7	-O	-o	CD
cord-259603-bh198xgl	565	8	-	-	HYPH
cord-259603-bh198xgl	565	9	MTase	mtase	JJ
cord-259603-bh198xgl	565	10	activity	activity	NN
cord-259603-bh198xgl	565	11	.	.	.
cord-259603-bh198xgl	566	1	In	in	IN
cord-259603-bh198xgl	566	2	the	the	DT
cord-259603-bh198xgl	566	3	following	following	JJ
cord-259603-bh198xgl	566	4	paragraphs	paragraph	NNS
cord-259603-bh198xgl	566	5	,	,	,
cord-259603-bh198xgl	566	6	we	-PRON-	PRP
cord-259603-bh198xgl	566	7	will	will	MD
cord-259603-bh198xgl	566	8	describe	describe	VB
cord-259603-bh198xgl	566	9	the	the	DT
cord-259603-bh198xgl	566	10	different	different	JJ
cord-259603-bh198xgl	566	11	CoV	cov	NN
cord-259603-bh198xgl	566	12	enzymes	enzyme	NNS
cord-259603-bh198xgl	566	13	involved	involve	VBN
cord-259603-bh198xgl	566	14	in	in	IN
cord-259603-bh198xgl	566	15	mRNA	mrna	NN
cord-259603-bh198xgl	566	16	capping	cap	VBG
cord-259603-bh198xgl	566	17	in	in	IN
cord-259603-bh198xgl	566	18	more	more	JJR
cord-259603-bh198xgl	566	19	detail	detail	NN
cord-259603-bh198xgl	566	20	.	.	.
cord-259603-bh198xgl	567	1	As	as	IN
cord-259603-bh198xgl	567	2	described	describe	VBN
cord-259603-bh198xgl	567	3	earlier	early	RBR
cord-259603-bh198xgl	567	4	,	,	,
cord-259603-bh198xgl	567	5	the	the	DT
cord-259603-bh198xgl	567	6	nsp13	nsp13	NNP
cord-259603-bh198xgl	567	7	helicase	helicase	NN
cord-259603-bh198xgl	567	8	domain	domain	NN
cord-259603-bh198xgl	567	9	is	be	VBZ
cord-259603-bh198xgl	567	10	thought	think	VBN
cord-259603-bh198xgl	567	11	to	to	TO
cord-259603-bh198xgl	567	12	unwind	unwind	VB
cord-259603-bh198xgl	567	13	double	double	RB
cord-259603-bh198xgl	567	14	-	-	HYPH
cord-259603-bh198xgl	567	15	stranded	strand	VBN
cord-259603-bh198xgl	567	16	RNA	RNA	NNP
cord-259603-bh198xgl	567	17	in	in	IN
cord-259603-bh198xgl	567	18	a	a	DT
cord-259603-bh198xgl	567	19	5	5	CD
cord-259603-bh198xgl	567	20	0	0	CD
cord-259603-bh198xgl	567	21	-to-3	-to-3	CD
cord-259603-bh198xgl	567	22	0	0	CD
cord-259603-bh198xgl	567	23	direction	direction	NN
cord-259603-bh198xgl	567	24	,	,	,
cord-259603-bh198xgl	567	25	an	an	DT
cord-259603-bh198xgl	567	26	activity	activity	NN
cord-259603-bh198xgl	567	27	that	that	WDT
cord-259603-bh198xgl	567	28	energetically	energetically	RB
cord-259603-bh198xgl	567	29	depends	depend	VBZ
cord-259603-bh198xgl	567	30	on	on	IN
cord-259603-bh198xgl	567	31	the	the	DT
cord-259603-bh198xgl	567	32	nucleotide	nucleotide	JJ
cord-259603-bh198xgl	567	33	triphosphatase	triphosphatase	NN
cord-259603-bh198xgl	567	34	(	(	-LRB-
cord-259603-bh198xgl	567	35	NTPase	NTPase	NNP
cord-259603-bh198xgl	567	36	)	)	-RRB-
cord-259603-bh198xgl	567	37	function	function	NN
cord-259603-bh198xgl	567	38	of	of	IN
cord-259603-bh198xgl	567	39	the	the	DT
cord-259603-bh198xgl	567	40	enzyme	enzyme	NN
cord-259603-bh198xgl	567	41	(	(	-LRB-
cord-259603-bh198xgl	567	42	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	567	43	and	and	CC
cord-259603-bh198xgl	567	44	Ziebuhr	Ziebuhr	NNP
cord-259603-bh198xgl	567	45	,	,	,
cord-259603-bh198xgl	567	46	2004	2004	CD
cord-259603-bh198xgl	567	47	;	;	:
cord-259603-bh198xgl	567	48	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	567	49	et	et	NNP
cord-259603-bh198xgl	567	50	al	al	NNP
cord-259603-bh198xgl	567	51	.	.	NNP
cord-259603-bh198xgl	567	52	,	,	,
cord-259603-bh198xgl	567	53	2004b	2004b	CD
cord-259603-bh198xgl	567	54	;	;	:
cord-259603-bh198xgl	567	55	Seybert	Seybert	NNP
cord-259603-bh198xgl	567	56	et	et	NNP
cord-259603-bh198xgl	567	57	al	al	NNP
cord-259603-bh198xgl	567	58	.	.	NNP
cord-259603-bh198xgl	567	59	,	,	,
cord-259603-bh198xgl	567	60	2000a	2000a	CD
cord-259603-bh198xgl	567	61	)	)	-RRB-
cord-259603-bh198xgl	567	62	.	.	.
cord-259603-bh198xgl	568	1	Additionally	additionally	RB
cord-259603-bh198xgl	568	2	,	,	,
cord-259603-bh198xgl	568	3	using	use	VBG
cord-259603-bh198xgl	568	4	the	the	DT
cord-259603-bh198xgl	568	5	same	same	JJ
cord-259603-bh198xgl	568	6	active	active	JJ
cord-259603-bh198xgl	568	7	site	site	NN
cord-259603-bh198xgl	568	8	,	,	,
cord-259603-bh198xgl	568	9	the	the	DT
cord-259603-bh198xgl	568	10	protein	protein	NN
cord-259603-bh198xgl	568	11	was	be	VBD
cord-259603-bh198xgl	568	12	found	find	VBN
cord-259603-bh198xgl	568	13	to	to	TO
cord-259603-bh198xgl	568	14	exhibit	exhibit	VB
cord-259603-bh198xgl	568	15	RTPase	rtpase	NN
cord-259603-bh198xgl	568	16	activity	activity	NN
cord-259603-bh198xgl	568	17	(	(	-LRB-
cord-259603-bh198xgl	568	18	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	568	19	and	and	CC
cord-259603-bh198xgl	568	20	Ziebuhr	Ziebuhr	NNP
cord-259603-bh198xgl	568	21	,	,	,
cord-259603-bh198xgl	568	22	2004	2004	CD
cord-259603-bh198xgl	568	23	)	)	-RRB-
cord-259603-bh198xgl	568	24	,	,	,
cord-259603-bh198xgl	568	25	which	which	WDT
cord-259603-bh198xgl	568	26	was	be	VBD
cord-259603-bh198xgl	568	27	found	find	VBN
cord-259603-bh198xgl	568	28	to	to	TO
cord-259603-bh198xgl	568	29	be	be	VB
cord-259603-bh198xgl	568	30	abolished	abolish	VBN
cord-259603-bh198xgl	568	31	if	if	IN
cord-259603-bh198xgl	568	32	the	the	DT
cord-259603-bh198xgl	568	33	conserved	conserved	JJ
cord-259603-bh198xgl	568	34	active	active	JJ
cord-259603-bh198xgl	568	35	-	-	HYPH
cord-259603-bh198xgl	568	36	site	site	NN
cord-259603-bh198xgl	568	37	Lys	Lys	NNP
cord-259603-bh198xgl	568	38	residue	residue	NN
cord-259603-bh198xgl	568	39	of	of	IN
cord-259603-bh198xgl	568	40	the	the	DT
cord-259603-bh198xgl	568	41	Walker	Walker	NNP
cord-259603-bh198xgl	568	42	A	A	NNP
cord-259603-bh198xgl	568	43	box	box	NN
cord-259603-bh198xgl	568	44	motif	motif	NN
cord-259603-bh198xgl	568	45	was	be	VBD
cord-259603-bh198xgl	568	46	replaced	replace	VBN
cord-259603-bh198xgl	568	47	with	with	IN
cord-259603-bh198xgl	568	48	Ala	Ala	NNP
cord-259603-bh198xgl	568	49	(	(	-LRB-
cord-259603-bh198xgl	568	50	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	568	51	and	and	CC
cord-259603-bh198xgl	568	52	Ziebuhr	Ziebuhr	NNP
cord-259603-bh198xgl	568	53	,	,	,
cord-259603-bh198xgl	568	54	2004	2004	CD
cord-259603-bh198xgl	568	55	;	;	:
cord-259603-bh198xgl	568	56	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	568	57	et	et	NNP
cord-259603-bh198xgl	568	58	al	al	NNP
cord-259603-bh198xgl	568	59	.	.	NNP
cord-259603-bh198xgl	568	60	,	,	,
cord-259603-bh198xgl	568	61	2004b	2004b	CD
cord-259603-bh198xgl	568	62	)	)	-RRB-
cord-259603-bh198xgl	568	63	.	.	.
cord-259603-bh198xgl	569	1	Specific	specific	JJ
cord-259603-bh198xgl	569	2	RTPase	rtpase	CD
cord-259603-bh198xgl	569	3	activity	activity	NN
cord-259603-bh198xgl	569	4	on	on	IN
cord-259603-bh198xgl	569	5	viral	viral	JJ
cord-259603-bh198xgl	569	6	mRNA	mrna	NN
cord-259603-bh198xgl	569	7	species	specie	NNS
cord-259603-bh198xgl	569	8	would	would	MD
cord-259603-bh198xgl	569	9	require	require	VB
cord-259603-bh198xgl	569	10	specific	specific	JJ
cord-259603-bh198xgl	569	11	recruitment	recruitment	NN
cord-259603-bh198xgl	569	12	of	of	IN
cord-259603-bh198xgl	569	13	nsp13	nsp13	ADD
cord-259603-bh198xgl	569	14	to	to	IN
cord-259603-bh198xgl	569	15	the	the	DT
cord-259603-bh198xgl	569	16	5	5	CD
cord-259603-bh198xgl	569	17	0	0	CD
cord-259603-bh198xgl	569	18	end	end	NN
cord-259603-bh198xgl	569	19	of	of	IN
cord-259603-bh198xgl	569	20	viral	viral	JJ
cord-259603-bh198xgl	569	21	mRNAs	mrna	NNS
cord-259603-bh198xgl	569	22	,	,	,
cord-259603-bh198xgl	569	23	which	which	WDT
cord-259603-bh198xgl	569	24	has	have	VBZ
cord-259603-bh198xgl	569	25	not	not	RB
cord-259603-bh198xgl	569	26	been	be	VBN
cord-259603-bh198xgl	569	27	demonstrated	demonstrate	VBN
cord-259603-bh198xgl	569	28	for	for	IN
cord-259603-bh198xgl	569	29	CoV	cov	NN
cord-259603-bh198xgl	569	30	helicases	helicase	NNS
cord-259603-bh198xgl	569	31	but	but	CC
cord-259603-bh198xgl	569	32	may	may	MD
cord-259603-bh198xgl	569	33	involve	involve	VB
cord-259603-bh198xgl	569	34	yet	yet	RB
cord-259603-bh198xgl	569	35	other	other	JJ
cord-259603-bh198xgl	569	36	factors	factor	NNS
cord-259603-bh198xgl	569	37	.	.	.
cord-259603-bh198xgl	570	1	In	in	IN
cord-259603-bh198xgl	570	2	this	this	DT
cord-259603-bh198xgl	570	3	context	context	NN
cord-259603-bh198xgl	570	4	,	,	,
cord-259603-bh198xgl	570	5	it	-PRON-	PRP
cord-259603-bh198xgl	570	6	remains	remain	VBZ
cord-259603-bh198xgl	570	7	to	to	TO
cord-259603-bh198xgl	570	8	be	be	VB
cord-259603-bh198xgl	570	9	studied	study	VBN
cord-259603-bh198xgl	570	10	if	if	IN
cord-259603-bh198xgl	570	11	the	the	DT
cord-259603-bh198xgl	570	12	common	common	JJ
cord-259603-bh198xgl	570	13	leader	leader	NN
cord-259603-bh198xgl	570	14	sequence	sequence	NN
cord-259603-bh198xgl	570	15	present	present	JJ
cord-259603-bh198xgl	570	16	on	on	IN
cord-259603-bh198xgl	570	17	CoV	CoV	NNP
cord-259603-bh198xgl	570	18	mRNAs	mRNAs	NNPS
cord-259603-bh198xgl	570	19	contributes	contribute	VBZ
cord-259603-bh198xgl	570	20	to	to	IN
cord-259603-bh198xgl	570	21	the	the	DT
cord-259603-bh198xgl	570	22	recruitment	recruitment	NN
cord-259603-bh198xgl	570	23	of	of	IN
cord-259603-bh198xgl	570	24	nsp13	nsp13	NNP
cord-259603-bh198xgl	570	25	and/or	and/or	CC
cord-259603-bh198xgl	570	26	other	other	JJ
cord-259603-bh198xgl	570	27	proteins	protein	NNS
cord-259603-bh198xgl	570	28	involved	involve	VBN
cord-259603-bh198xgl	570	29	in	in	IN
cord-259603-bh198xgl	570	30	5	5	CD
cord-259603-bh198xgl	570	31	0	0	CD
cord-259603-bh198xgl	570	32	capping	cap	VBG
cord-259603-bh198xgl	570	33	reactions	reaction	NNS
cord-259603-bh198xgl	570	34	.	.	.
cord-259603-bh198xgl	571	1	Several	several	JJ
cord-259603-bh198xgl	571	2	other	other	JJ
cord-259603-bh198xgl	571	3	+	+	CC
cord-259603-bh198xgl	571	4	RNA	RNA	NNP
cord-259603-bh198xgl	571	5	virus	virus	NN
cord-259603-bh198xgl	571	6	helicases	helicase	NNS
cord-259603-bh198xgl	571	7	were	be	VBD
cord-259603-bh198xgl	571	8	shown	show	VBN
cord-259603-bh198xgl	571	9	to	to	TO
cord-259603-bh198xgl	571	10	possess	possess	VB
cord-259603-bh198xgl	571	11	an	an	DT
cord-259603-bh198xgl	571	12	activity	activity	NN
cord-259603-bh198xgl	571	13	that	that	WDT
cord-259603-bh198xgl	571	14	can	can	MD
cord-259603-bh198xgl	571	15	target	target	VB
cord-259603-bh198xgl	571	16	the	the	DT
cord-259603-bh198xgl	571	17	phosphodiester	phosphodiester	NN
cord-259603-bh198xgl	571	18	bond	bond	NN
cord-259603-bh198xgl	571	19	between	between	IN
cord-259603-bh198xgl	571	20	the	the	DT
cord-259603-bh198xgl	571	21	β	β	NN
cord-259603-bh198xgl	571	22	and	and	CC
cord-259603-bh198xgl	571	23	γ	γ	NN
cord-259603-bh198xgl	571	24	phosphate	phosphate	NN
cord-259603-bh198xgl	571	25	groups	group	NNS
cord-259603-bh198xgl	571	26	of	of	IN
cord-259603-bh198xgl	571	27	the	the	DT
cord-259603-bh198xgl	571	28	5	5	CD
cord-259603-bh198xgl	571	29	0	0	CD
cord-259603-bh198xgl	571	30	-terminal	-terminal	JJ
cord-259603-bh198xgl	571	31	NTP	ntp	NN
cord-259603-bh198xgl	571	32	of	of	IN
cord-259603-bh198xgl	571	33	diverse	diverse	JJ
cord-259603-bh198xgl	571	34	substrate	substrate	NN
cord-259603-bh198xgl	571	35	RNAs	rna	NNS
cord-259603-bh198xgl	571	36	,	,	,
cord-259603-bh198xgl	571	37	suggesting	suggest	VBG
cord-259603-bh198xgl	571	38	that	that	IN
cord-259603-bh198xgl	571	39	this	this	DT
cord-259603-bh198xgl	571	40	dual	dual	JJ
cord-259603-bh198xgl	571	41	function	function	NN
cord-259603-bh198xgl	571	42	of	of	IN
cord-259603-bh198xgl	571	43	helicase	helicase	NN
cord-259603-bh198xgl	571	44	and	and	CC
cord-259603-bh198xgl	571	45	capping	cap	VBG
cord-259603-bh198xgl	571	46	RTPase	RTPase	NNP
cord-259603-bh198xgl	571	47	is	be	VBZ
cord-259603-bh198xgl	571	48	a	a	DT
cord-259603-bh198xgl	571	49	common	common	JJ
cord-259603-bh198xgl	571	50	feature	feature	NN
cord-259603-bh198xgl	571	51	in	in	IN
cord-259603-bh198xgl	571	52	this	this	DT
cord-259603-bh198xgl	571	53	group	group	NN
cord-259603-bh198xgl	571	54	of	of	IN
cord-259603-bh198xgl	571	55	viruses	virus	NNS
cord-259603-bh198xgl	571	56	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	571	57	and	and	CC
cord-259603-bh198xgl	571	58	Ziebuhr	Ziebuhr	NNP
cord-259603-bh198xgl	571	59	,	,	,
cord-259603-bh198xgl	571	60	2004	2004	CD
cord-259603-bh198xgl	571	61	)	)	-RRB-
cord-259603-bh198xgl	571	62	.	.	.
cord-259603-bh198xgl	572	1	Even	even	RB
cord-259603-bh198xgl	572	2	though	though	IN
cord-259603-bh198xgl	572	3	experimental	experimental	JJ
cord-259603-bh198xgl	572	4	evidence	evidence	NN
cord-259603-bh198xgl	572	5	has	have	VBZ
cord-259603-bh198xgl	572	6	been	be	VBN
cord-259603-bh198xgl	572	7	obtained	obtain	VBN
cord-259603-bh198xgl	572	8	to	to	TO
cord-259603-bh198xgl	572	9	suggest	suggest	VB
cord-259603-bh198xgl	572	10	an	an	DT
cord-259603-bh198xgl	572	11	nsp13-associated	nsp13-associate	VBN
cord-259603-bh198xgl	572	12	5	5	CD
cord-259603-bh198xgl	572	13	0	0	CD
cord-259603-bh198xgl	572	14	RTPase	rtpase	NN
cord-259603-bh198xgl	572	15	activity	activity	NN
cord-259603-bh198xgl	572	16	,	,	,
cord-259603-bh198xgl	572	17	coronavirus	coronavirus	NN
cord-259603-bh198xgl	572	18	nsp13	nsp13	CD
cord-259603-bh198xgl	572	19	homologs	homolog	NNS
cord-259603-bh198xgl	572	20	proved	prove	VBN
cord-259603-bh198xgl	572	21	to	to	TO
cord-259603-bh198xgl	572	22	be	be	VB
cord-259603-bh198xgl	572	23	unable	unable	JJ
cord-259603-bh198xgl	572	24	to	to	TO
cord-259603-bh198xgl	572	25	transcomplement	transcomplement	VB
cord-259603-bh198xgl	572	26	the	the	DT
cord-259603-bh198xgl	572	27	yeast	yeast	NN
cord-259603-bh198xgl	572	28	strain	strain	NN
cord-259603-bh198xgl	572	29	YBS20	ybs20	PRP
cord-259603-bh198xgl	572	30	,	,	,
cord-259603-bh198xgl	572	31	which	which	WDT
cord-259603-bh198xgl	572	32	lacks	lack	VBZ
cord-259603-bh198xgl	572	33	the	the	DT
cord-259603-bh198xgl	572	34	CET1	CET1	NNP
cord-259603-bh198xgl	572	35	locus	locus	NN
cord-259603-bh198xgl	572	36	encoding	encode	VBG
cord-259603-bh198xgl	572	37	the	the	DT
cord-259603-bh198xgl	572	38	yeast	yeast	NN
cord-259603-bh198xgl	573	1	RTPase	rtpase	LS
cord-259603-bh198xgl	573	2	involved	involve	VBN
cord-259603-bh198xgl	573	3	in	in	IN
cord-259603-bh198xgl	573	4	mRNA	mrna	NN
cord-259603-bh198xgl	573	5	capping	cap	VBG
cord-259603-bh198xgl	574	1	(	(	-LRB-
cord-259603-bh198xgl	574	2	Chen	Chen	NNP
cord-259603-bh198xgl	574	3	et	et	NNP
cord-259603-bh198xgl	574	4	al	al	NNP
cord-259603-bh198xgl	574	5	.	.	.
cord-259603-bh198xgl	575	1	,	,	,
cord-259603-bh198xgl	575	2	2009c	2009c	CD
cord-259603-bh198xgl	575	3	)	)	-RRB-
cord-259603-bh198xgl	575	4	.	.	.
cord-259603-bh198xgl	576	1	The	the	DT
cord-259603-bh198xgl	576	2	lack	lack	NN
cord-259603-bh198xgl	576	3	of	of	IN
cord-259603-bh198xgl	576	4	trans	trans	NN
cord-259603-bh198xgl	576	5	-	-	NN
cord-259603-bh198xgl	576	6	complementation	complementation	NN
cord-259603-bh198xgl	576	7	by	by	IN
cord-259603-bh198xgl	576	8	nsp13	nsp13	NNP
cord-259603-bh198xgl	576	9	could	could	MD
cord-259603-bh198xgl	576	10	be	be	VB
cord-259603-bh198xgl	576	11	due	due	JJ
cord-259603-bh198xgl	576	12	to	to	IN
cord-259603-bh198xgl	576	13	technical	technical	JJ
cord-259603-bh198xgl	576	14	reasons	reason	NNS
cord-259603-bh198xgl	576	15	,	,	,
cord-259603-bh198xgl	576	16	such	such	JJ
cord-259603-bh198xgl	576	17	as	as	IN
cord-259603-bh198xgl	576	18	inappropriate	inappropriate	JJ
cord-259603-bh198xgl	576	19	subcellular	subcellular	JJ
cord-259603-bh198xgl	576	20	localization	localization	NN
cord-259603-bh198xgl	576	21	of	of	IN
cord-259603-bh198xgl	576	22	nsp13	nsp13	CD
cord-259603-bh198xgl	576	23	,	,	,
cord-259603-bh198xgl	576	24	misfolding	misfolde	VBG
cord-259603-bh198xgl	576	25	of	of	IN
cord-259603-bh198xgl	576	26	the	the	DT
cord-259603-bh198xgl	576	27	protein	protein	NN
cord-259603-bh198xgl	576	28	,	,	,
cord-259603-bh198xgl	576	29	or	or	CC
cord-259603-bh198xgl	576	30	a	a	DT
cord-259603-bh198xgl	576	31	functional	functional	JJ
cord-259603-bh198xgl	576	32	mismatch	mismatch	NN
cord-259603-bh198xgl	576	33	with	with	IN
cord-259603-bh198xgl	576	34	other	other	JJ
cord-259603-bh198xgl	576	35	players	player	NNS
cord-259603-bh198xgl	576	36	of	of	IN
cord-259603-bh198xgl	576	37	the	the	DT
cord-259603-bh198xgl	576	38	distantly	distantly	RB
cord-259603-bh198xgl	576	39	related	relate	VBN
cord-259603-bh198xgl	576	40	yeast	yeast	NN
cord-259603-bh198xgl	576	41	capping	cap	VBG
cord-259603-bh198xgl	576	42	machinery	machinery	NN
cord-259603-bh198xgl	576	43	.	.	.
cord-259603-bh198xgl	577	1	Alternatively	alternatively	RB
cord-259603-bh198xgl	577	2	,	,	,
cord-259603-bh198xgl	577	3	it	-PRON-	PRP
cord-259603-bh198xgl	577	4	could	could	MD
cord-259603-bh198xgl	577	5	indicate	indicate	VB
cord-259603-bh198xgl	577	6	specific	specific	JJ
cord-259603-bh198xgl	577	7	substrate	substrate	NN
cord-259603-bh198xgl	577	8	requirements	requirement	NNS
cord-259603-bh198xgl	577	9	for	for	IN
cord-259603-bh198xgl	577	10	coronavirus	coronavirus	NN
cord-259603-bh198xgl	577	11	nsp13-associated	nsp13-associate	VBN
cord-259603-bh198xgl	577	12	RTPase	RTPase	NNP
cord-259603-bh198xgl	577	13	activities	activity	NNS
cord-259603-bh198xgl	577	14	.	.	.
cord-259603-bh198xgl	578	1	In	in	IN
cord-259603-bh198xgl	578	2	any	any	DT
cord-259603-bh198xgl	578	3	case	case	NN
cord-259603-bh198xgl	578	4	,	,	,
cord-259603-bh198xgl	578	5	a	a	DT
cord-259603-bh198xgl	578	6	possible	possible	JJ
cord-259603-bh198xgl	578	7	involvement	involvement	NN
cord-259603-bh198xgl	578	8	of	of	IN
cord-259603-bh198xgl	578	9	nsp13	nsp13	CD
cord-259603-bh198xgl	578	10	in	in	IN
cord-259603-bh198xgl	578	11	the	the	DT
cord-259603-bh198xgl	578	12	first	first	JJ
cord-259603-bh198xgl	578	13	step	step	NN
cord-259603-bh198xgl	578	14	of	of	IN
cord-259603-bh198xgl	578	15	CoV	CoV	NNP
cord-259603-bh198xgl	578	16	mRNA	mRNA	NNP
cord-259603-bh198xgl	578	17	capping	cap	VBG
cord-259603-bh198xgl	578	18	remains	remain	VBZ
cord-259603-bh198xgl	578	19	to	to	TO
cord-259603-bh198xgl	578	20	be	be	VB
cord-259603-bh198xgl	578	21	corroborated	corroborate	VBN
cord-259603-bh198xgl	578	22	in	in	IN
cord-259603-bh198xgl	578	23	further	further	JJ
cord-259603-bh198xgl	578	24	studies	study	NNS
cord-259603-bh198xgl	578	25	,	,	,
cord-259603-bh198xgl	578	26	for	for	IN
cord-259603-bh198xgl	578	27	example	example	NN
cord-259603-bh198xgl	578	28	,	,	,
cord-259603-bh198xgl	578	29	by	by	IN
cord-259603-bh198xgl	578	30	in	in	FW
cord-259603-bh198xgl	578	31	vitro	vitro	FW
cord-259603-bh198xgl	578	32	reconstitution	reconstitution	NN
cord-259603-bh198xgl	578	33	experiments	experiment	NNS
cord-259603-bh198xgl	578	34	of	of	IN
cord-259603-bh198xgl	578	35	the	the	DT
cord-259603-bh198xgl	578	36	entire	entire	JJ
cord-259603-bh198xgl	578	37	CoV	cov	NN
cord-259603-bh198xgl	578	38	capping	cap	VBG
cord-259603-bh198xgl	578	39	pathway	pathway	NN
cord-259603-bh198xgl	578	40	.	.	.
cord-259603-bh198xgl	579	1	The	the	DT
cord-259603-bh198xgl	579	2	CoV	cov	NN
cord-259603-bh198xgl	579	3	nsp	nsp	NN
cord-259603-bh198xgl	579	4	involved	involve	VBN
cord-259603-bh198xgl	579	5	in	in	IN
cord-259603-bh198xgl	579	6	the	the	DT
cord-259603-bh198xgl	579	7	second	second	JJ
cord-259603-bh198xgl	579	8	step	step	NN
cord-259603-bh198xgl	579	9	of	of	IN
cord-259603-bh198xgl	579	10	RNA	RNA	NNP
cord-259603-bh198xgl	579	11	capping	capping	NN
cord-259603-bh198xgl	579	12	,	,	,
cord-259603-bh198xgl	579	13	GTase	GTase	NNP
cord-259603-bh198xgl	579	14	,	,	,
cord-259603-bh198xgl	579	15	remains	remain	VBZ
cord-259603-bh198xgl	579	16	to	to	TO
cord-259603-bh198xgl	579	17	be	be	VB
cord-259603-bh198xgl	579	18	identified	identify	VBN
cord-259603-bh198xgl	579	19	.	.	.
cord-259603-bh198xgl	580	1	Bioinformatics	Bioinformatics	NNP
cord-259603-bh198xgl	580	2	analysis	analysis	NN
cord-259603-bh198xgl	580	3	of	of	IN
cord-259603-bh198xgl	580	4	CoV	CoV	NNP
cord-259603-bh198xgl	580	5	genome	genome	NN
cord-259603-bh198xgl	580	6	sequences	sequence	NNS
cord-259603-bh198xgl	580	7	failed	fail	VBD
cord-259603-bh198xgl	580	8	to	to	TO
cord-259603-bh198xgl	580	9	identify	identify	VB
cord-259603-bh198xgl	580	10	replicase	replicase	NN
cord-259603-bh198xgl	580	11	gene	gene	NN
cord-259603-bh198xgl	580	12	-	-	HYPH
cord-259603-bh198xgl	580	13	encoded	encode	VBN
cord-259603-bh198xgl	580	14	domains	domain	NNS
cord-259603-bh198xgl	580	15	that	that	WDT
cord-259603-bh198xgl	580	16	may	may	MD
cord-259603-bh198xgl	580	17	perform	perform	VB
cord-259603-bh198xgl	580	18	this	this	DT
cord-259603-bh198xgl	580	19	activity	activity	NN
cord-259603-bh198xgl	580	20	.	.	.
cord-259603-bh198xgl	581	1	Eukaryotic	Eukaryotic	NNP
cord-259603-bh198xgl	581	2	RNA	RNA	NNP
cord-259603-bh198xgl	581	3	capping	cap	VBG
cord-259603-bh198xgl	581	4	enzymes	enzyme	NNS
cord-259603-bh198xgl	581	5	belong	belong	VBP
cord-259603-bh198xgl	581	6	to	to	IN
cord-259603-bh198xgl	581	7	the	the	DT
cord-259603-bh198xgl	581	8	ligase	ligase	NN
cord-259603-bh198xgl	581	9	family	family	NN
cord-259603-bh198xgl	581	10	and	and	CC
cord-259603-bh198xgl	581	11	have	have	VBP
cord-259603-bh198xgl	581	12	been	be	VBN
cord-259603-bh198xgl	581	13	shown	show	VBN
cord-259603-bh198xgl	581	14	to	to	TO
cord-259603-bh198xgl	581	15	form	form	VB
cord-259603-bh198xgl	581	16	a	a	DT
cord-259603-bh198xgl	581	17	GTase	GTase	NNP
cord-259603-bh198xgl	581	18	-	-	HYPH
cord-259603-bh198xgl	581	19	GMP	GMP	NNP
cord-259603-bh198xgl	581	20	adduct	adduct	NN
cord-259603-bh198xgl	581	21	upon	upon	IN
cord-259603-bh198xgl	581	22	incubation	incubation	NN
cord-259603-bh198xgl	581	23	with	with	IN
cord-259603-bh198xgl	581	24	GTP	GTP	NNP
cord-259603-bh198xgl	581	25	.	.	.
cord-259603-bh198xgl	582	1	A	a	DT
cord-259603-bh198xgl	582	2	substantial	substantial	JJ
cord-259603-bh198xgl	582	3	number	number	NN
cord-259603-bh198xgl	582	4	of	of	IN
cord-259603-bh198xgl	582	5	SARS	SARS	NNP
cord-259603-bh198xgl	582	6	-	-	HYPH
cord-259603-bh198xgl	582	7	CoV	CoV	NNP
cord-259603-bh198xgl	582	8	nsps	nsp	NNS
cord-259603-bh198xgl	582	9	were	be	VBD
cord-259603-bh198xgl	582	10	expressed	express	VBN
cord-259603-bh198xgl	582	11	and	and	CC
cord-259603-bh198xgl	582	12	purified	purify	VBN
cord-259603-bh198xgl	582	13	(	(	-LRB-
cord-259603-bh198xgl	582	14	nsp7	nsp7	UH
cord-259603-bh198xgl	582	15	,	,	,
cord-259603-bh198xgl	582	16	nsp8	nsp8	NN
cord-259603-bh198xgl	582	17	,	,	,
cord-259603-bh198xgl	582	18	nsp10	nsp10	RB
cord-259603-bh198xgl	582	19	,	,	,
cord-259603-bh198xgl	582	20	and	and	CC
cord-259603-bh198xgl	582	21	nsp12	nsp12	CD
cord-259603-bh198xgl	582	22	-	-	SYM
cord-259603-bh198xgl	582	23	16	16	CD
cord-259603-bh198xgl	582	24	)	)	-RRB-
cord-259603-bh198xgl	582	25	,	,	,
cord-259603-bh198xgl	582	26	but	but	CC
cord-259603-bh198xgl	582	27	covalent	covalent	JJ
cord-259603-bh198xgl	582	28	linkage	linkage	NN
cord-259603-bh198xgl	582	29	of	of	IN
cord-259603-bh198xgl	582	30	GMP	GMP	NNP
cord-259603-bh198xgl	582	31	to	to	IN
cord-259603-bh198xgl	582	32	any	any	DT
cord-259603-bh198xgl	582	33	these	these	DT
cord-259603-bh198xgl	582	34	proteins	protein	NNS
cord-259603-bh198xgl	582	35	could	could	MD
cord-259603-bh198xgl	582	36	not	not	RB
cord-259603-bh198xgl	582	37	be	be	VB
cord-259603-bh198xgl	582	38	demonstrated	demonstrate	VBN
cord-259603-bh198xgl	582	39	(	(	-LRB-
cord-259603-bh198xgl	582	40	Jin	Jin	NNP
cord-259603-bh198xgl	582	41	et	et	NNP
cord-259603-bh198xgl	582	42	al	al	NNP
cord-259603-bh198xgl	582	43	.	.	NNP
cord-259603-bh198xgl	582	44	,	,	,
cord-259603-bh198xgl	582	45	2013	2013	CD
cord-259603-bh198xgl	582	46	)	)	-RRB-
cord-259603-bh198xgl	582	47	.	.	.
cord-259603-bh198xgl	583	1	In	in	IN
cord-259603-bh198xgl	583	2	addition	addition	NN
cord-259603-bh198xgl	583	3	,	,	,
cord-259603-bh198xgl	583	4	nsps	nsp	NNS
cord-259603-bh198xgl	583	5	were	be	VBD
cord-259603-bh198xgl	583	6	screened	screen	VBN
cord-259603-bh198xgl	583	7	for	for	IN
cord-259603-bh198xgl	583	8	GTase	GTase	NNP
cord-259603-bh198xgl	583	9	activity	activity	NN
cord-259603-bh198xgl	583	10	in	in	IN
cord-259603-bh198xgl	583	11	a	a	DT
cord-259603-bh198xgl	583	12	yeast	yeast	NN
cord-259603-bh198xgl	583	13	trans	trans	NN
cord-259603-bh198xgl	583	14	-	-	NN
cord-259603-bh198xgl	583	15	complementation	complementation	NN
cord-259603-bh198xgl	583	16	system	system	NN
cord-259603-bh198xgl	583	17	using	use	VBG
cord-259603-bh198xgl	583	18	the	the	DT
cord-259603-bh198xgl	583	19	YBS2	YBS2	NNP
cord-259603-bh198xgl	583	20	strain	strain	NN
cord-259603-bh198xgl	583	21	lacking	lack	VBG
cord-259603-bh198xgl	583	22	the	the	DT
cord-259603-bh198xgl	583	23	gene	gene	NN
cord-259603-bh198xgl	583	24	(	(	-LRB-
cord-259603-bh198xgl	583	25	ceg1	ceg1	CD
cord-259603-bh198xgl	583	26	)	)	-RRB-
cord-259603-bh198xgl	583	27	encoding	encode	VBG
cord-259603-bh198xgl	583	28	the	the	DT
cord-259603-bh198xgl	583	29	yeast	yeast	NN
cord-259603-bh198xgl	584	1	GTase	GTase	NNP
cord-259603-bh198xgl	585	1	(	(	-LRB-
cord-259603-bh198xgl	585	2	Chen	Chen	NNP
cord-259603-bh198xgl	585	3	et	et	NNP
cord-259603-bh198xgl	585	4	al	al	NNP
cord-259603-bh198xgl	585	5	.	.	NNP
cord-259603-bh198xgl	585	6	,	,	,
cord-259603-bh198xgl	585	7	2009c	2009c	CD
cord-259603-bh198xgl	585	8	)	)	-RRB-
cord-259603-bh198xgl	585	9	,	,	.
cord-259603-bh198xgl	586	1	but	but	CC
cord-259603-bh198xgl	586	2	also	also	RB
cord-259603-bh198xgl	586	3	this	this	DT
cord-259603-bh198xgl	586	4	powerful	powerful	JJ
cord-259603-bh198xgl	586	5	approach	approach	NN
cord-259603-bh198xgl	586	6	failed	fail	VBD
cord-259603-bh198xgl	586	7	to	to	TO
cord-259603-bh198xgl	586	8	identify	identify	VB
cord-259603-bh198xgl	586	9	the	the	DT
cord-259603-bh198xgl	586	10	CoV	cov	NN
cord-259603-bh198xgl	586	11	GTase	GTase	NNP
cord-259603-bh198xgl	586	12	.	.	.
cord-259603-bh198xgl	587	1	Consequently	consequently	RB
cord-259603-bh198xgl	587	2	,	,	,
cord-259603-bh198xgl	587	3	several	several	JJ
cord-259603-bh198xgl	587	4	hypotheses	hypothesis	NNS
cord-259603-bh198xgl	587	5	remain	remain	VBP
cord-259603-bh198xgl	587	6	to	to	TO
cord-259603-bh198xgl	587	7	be	be	VB
cord-259603-bh198xgl	587	8	explored	explore	VBN
cord-259603-bh198xgl	587	9	.	.	.
cord-259603-bh198xgl	588	1	First	first	RB
cord-259603-bh198xgl	588	2	,	,	,
cord-259603-bh198xgl	588	3	it	-PRON-	PRP
cord-259603-bh198xgl	588	4	is	be	VBZ
cord-259603-bh198xgl	588	5	possible	possible	JJ
cord-259603-bh198xgl	588	6	that	that	IN
cord-259603-bh198xgl	588	7	the	the	DT
cord-259603-bh198xgl	588	8	N	n	CD
cord-259603-bh198xgl	588	9	-	-	HYPH
cord-259603-bh198xgl	588	10	terminal	terminal	NN
cord-259603-bh198xgl	588	11	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	588	12	domain	domain	NN
cord-259603-bh198xgl	588	13	of	of	IN
cord-259603-bh198xgl	588	14	nsp12	nsp12	NNS
cord-259603-bh198xgl	588	15	(	(	-LRB-
cord-259603-bh198xgl	588	16	see	see	VB
cord-259603-bh198xgl	588	17	earlier	early	RBR
cord-259603-bh198xgl	588	18	)	)	-RRB-
cord-259603-bh198xgl	588	19	forms	form	VBZ
cord-259603-bh198xgl	588	20	a	a	DT
cord-259603-bh198xgl	588	21	covalent	covalent	JJ
cord-259603-bh198xgl	588	22	adduct	adduct	NN
cord-259603-bh198xgl	588	23	with	with	IN
cord-259603-bh198xgl	588	24	GTP	GTP	NNP
cord-259603-bh198xgl	588	25	,	,	,
cord-259603-bh198xgl	588	26	as	as	IN
cord-259603-bh198xgl	588	27	observed	observe	VBN
cord-259603-bh198xgl	588	28	for	for	IN
cord-259603-bh198xgl	588	29	its	-PRON-	PRP$
cord-259603-bh198xgl	588	30	arterivirus	arterivirus	NNP
cord-259603-bh198xgl	588	31	homolog	homolog	NN
cord-259603-bh198xgl	588	32	nsp9	nsp9	NNP
cord-259603-bh198xgl	589	1	(	(	-LRB-
cord-259603-bh198xgl	589	2	Lehmann	Lehmann	NNP
cord-259603-bh198xgl	589	3	et	et	NNP
cord-259603-bh198xgl	589	4	al	al	NNP
cord-259603-bh198xgl	589	5	.	.	NNP
cord-259603-bh198xgl	589	6	,	,	,
cord-259603-bh198xgl	589	7	2015a	2015a	CD
cord-259603-bh198xgl	589	8	)	)	-RRB-
cord-259603-bh198xgl	589	9	.	.	.
cord-259603-bh198xgl	590	1	Another	another	DT
cord-259603-bh198xgl	590	2	possibility	possibility	NN
cord-259603-bh198xgl	590	3	is	be	VBZ
cord-259603-bh198xgl	590	4	that	that	IN
cord-259603-bh198xgl	590	5	the	the	DT
cord-259603-bh198xgl	590	6	CoV	cov	NN
cord-259603-bh198xgl	590	7	capping	cap	VBG
cord-259603-bh198xgl	590	8	pathway	pathway	NN
cord-259603-bh198xgl	590	9	is	be	VBZ
cord-259603-bh198xgl	590	10	unconventional	unconventional	JJ
cord-259603-bh198xgl	590	11	and	and	CC
cord-259603-bh198xgl	590	12	,	,	,
cord-259603-bh198xgl	590	13	for	for	IN
cord-259603-bh198xgl	590	14	example	example	NN
cord-259603-bh198xgl	590	15	,	,	,
cord-259603-bh198xgl	590	16	resembles	resemble	VBZ
cord-259603-bh198xgl	590	17	that	that	DT
cord-259603-bh198xgl	590	18	of	of	IN
cord-259603-bh198xgl	590	19	alphaviruses	alphavirus	NNS
cord-259603-bh198xgl	590	20	in	in	IN
cord-259603-bh198xgl	590	21	which	which	WDT
cord-259603-bh198xgl	590	22	the	the	DT
cord-259603-bh198xgl	590	23	GTP	GTP	NNP
cord-259603-bh198xgl	590	24	molecule	molecule	NN
cord-259603-bh198xgl	590	25	needs	need	VBZ
cord-259603-bh198xgl	590	26	to	to	TO
cord-259603-bh198xgl	590	27	be	be	VB
cord-259603-bh198xgl	590	28	methylated	methylate	VBN
cord-259603-bh198xgl	590	29	at	at	IN
cord-259603-bh198xgl	590	30	its	-PRON-	PRP$
cord-259603-bh198xgl	590	31	N7	N7	NNP
cord-259603-bh198xgl	590	32	position	position	NN
cord-259603-bh198xgl	590	33	before	before	IN
cord-259603-bh198xgl	590	34	the	the	DT
cord-259603-bh198xgl	590	35	GTase	GTase	NNP
cord-259603-bh198xgl	590	36	-	-	HYPH
cord-259603-bh198xgl	590	37	m	m	NNP
cord-259603-bh198xgl	590	38	GMP	GMP	NNP
cord-259603-bh198xgl	590	39	adduct	adduct	NN
cord-259603-bh198xgl	590	40	can	can	MD
cord-259603-bh198xgl	590	41	be	be	VB
cord-259603-bh198xgl	590	42	formed	form	VBN
cord-259603-bh198xgl	590	43	(	(	-LRB-
cord-259603-bh198xgl	590	44	Ahola	Ahola	NNP
cord-259603-bh198xgl	590	45	and	and	CC
cord-259603-bh198xgl	590	46	Ahlquist	Ahlquist	NNP
cord-259603-bh198xgl	590	47	,	,	,
cord-259603-bh198xgl	590	48	1999	1999	CD
cord-259603-bh198xgl	590	49	)	)	-RRB-
cord-259603-bh198xgl	590	50	.	.	.
cord-259603-bh198xgl	591	1	Interestingly	interestingly	RB
cord-259603-bh198xgl	591	2	,	,	,
cord-259603-bh198xgl	591	3	this	this	DT
cord-259603-bh198xgl	591	4	second	second	JJ
cord-259603-bh198xgl	591	5	possibility	possibility	NN
cord-259603-bh198xgl	591	6	might	may	MD
cord-259603-bh198xgl	591	7	explain	explain	VB
cord-259603-bh198xgl	591	8	nsp14s	nsp14s	DT
cord-259603-bh198xgl	591	9	capability	capability	NN
cord-259603-bh198xgl	591	10	to	to	TO
cord-259603-bh198xgl	591	11	convert	convert	VB
cord-259603-bh198xgl	591	12	GTP	GTP	NNP
cord-259603-bh198xgl	591	13	into	into	IN
cord-259603-bh198xgl	591	14	m	m	NNP
cord-259603-bh198xgl	591	15	GTP	GTP	NNP
cord-259603-bh198xgl	591	16	(	(	-LRB-
cord-259603-bh198xgl	591	17	see	see	VB
cord-259603-bh198xgl	591	18	later	later	RB
cord-259603-bh198xgl	591	19	)	)	-RRB-
cord-259603-bh198xgl	592	1	(	(	-LRB-
cord-259603-bh198xgl	592	2	Jin	Jin	NNP
cord-259603-bh198xgl	592	3	et	et	NNP
cord-259603-bh198xgl	592	4	al	al	NNP
cord-259603-bh198xgl	592	5	.	.	NNP
cord-259603-bh198xgl	592	6	,	,	,
cord-259603-bh198xgl	592	7	2013	2013	CD
cord-259603-bh198xgl	592	8	)	)	-RRB-
cord-259603-bh198xgl	592	9	.	.	.
cord-259603-bh198xgl	593	1	Finally	finally	RB
cord-259603-bh198xgl	593	2	,	,	,
cord-259603-bh198xgl	593	3	the	the	DT
cord-259603-bh198xgl	593	4	involvement	involvement	NN
cord-259603-bh198xgl	593	5	of	of	IN
cord-259603-bh198xgl	593	6	a	a	DT
cord-259603-bh198xgl	593	7	host	host	NN
cord-259603-bh198xgl	594	1	GTase	GTase	NNP
cord-259603-bh198xgl	594	2	remains	remain	VBZ
cord-259603-bh198xgl	594	3	an	an	DT
cord-259603-bh198xgl	594	4	interesting	interesting	JJ
cord-259603-bh198xgl	594	5	possibility	possibility	NN
cord-259603-bh198xgl	594	6	,	,	,
cord-259603-bh198xgl	594	7	in	in	IN
cord-259603-bh198xgl	594	8	particular	particular	JJ
cord-259603-bh198xgl	594	9	since	since	IN
cord-259603-bh198xgl	594	10	cytoplasmic	cytoplasmic	JJ
cord-259603-bh198xgl	594	11	forms	form	NNS
cord-259603-bh198xgl	594	12	of	of	IN
cord-259603-bh198xgl	594	13	cellular	cellular	JJ
cord-259603-bh198xgl	594	14	capping	capping	NN
cord-259603-bh198xgl	594	15	enzymes	enzyme	NNS
cord-259603-bh198xgl	594	16	have	have	VBP
cord-259603-bh198xgl	594	17	been	be	VBN
cord-259603-bh198xgl	594	18	described	describe	VBN
cord-259603-bh198xgl	594	19	recently	recently	RB
cord-259603-bh198xgl	594	20	(	(	-LRB-
cord-259603-bh198xgl	595	1	Mukherjee	Mukherjee	NNP
cord-259603-bh198xgl	595	2	et	et	NNP
cord-259603-bh198xgl	595	3	al	al	NNP
cord-259603-bh198xgl	595	4	.	.	.
cord-259603-bh198xgl	596	1	,	,	,
cord-259603-bh198xgl	596	2	2012	2012	CD
cord-259603-bh198xgl	596	3	;	;	:
cord-259603-bh198xgl	596	4	Schoenberg	Schoenberg	NNP
cord-259603-bh198xgl	596	5	and	and	CC
cord-259603-bh198xgl	596	6	Maquat	Maquat	NNP
cord-259603-bh198xgl	596	7	,	,	,
cord-259603-bh198xgl	596	8	2009	2009	CD
cord-259603-bh198xgl	596	9	)	)	-RRB-
cord-259603-bh198xgl	596	10	.	.	.
cord-259603-bh198xgl	597	1	Further	further	JJ
cord-259603-bh198xgl	597	2	work	work	NN
cord-259603-bh198xgl	597	3	is	be	VBZ
cord-259603-bh198xgl	597	4	needed	need	VBN
cord-259603-bh198xgl	597	5	to	to	TO
cord-259603-bh198xgl	597	6	explore	explore	VB
cord-259603-bh198xgl	597	7	these	these	DT
cord-259603-bh198xgl	597	8	various	various	JJ
cord-259603-bh198xgl	597	9	hypotheses	hypothesis	NNS
cord-259603-bh198xgl	597	10	and	and	CC
cord-259603-bh198xgl	597	11	resolve	resolve	VB
cord-259603-bh198xgl	597	12	this	this	DT
cord-259603-bh198xgl	597	13	important	important	JJ
cord-259603-bh198xgl	597	14	question	question	NN
cord-259603-bh198xgl	597	15	.	.	.
cord-259603-bh198xgl	598	1	Coronavirus	Coronavirus	NNP
cord-259603-bh198xgl	598	2	nsp14	nsp14	NNP
cord-259603-bh198xgl	598	3	is	be	VBZ
cord-259603-bh198xgl	598	4	a	a	DT
cord-259603-bh198xgl	598	5	bifunctional	bifunctional	JJ
cord-259603-bh198xgl	598	6	protein	protein	NN
cord-259603-bh198xgl	598	7	that	that	WDT
cord-259603-bh198xgl	598	8	plays	play	VBZ
cord-259603-bh198xgl	598	9	a	a	DT
cord-259603-bh198xgl	598	10	crucial	crucial	JJ
cord-259603-bh198xgl	598	11	role	role	NN
cord-259603-bh198xgl	598	12	in	in	IN
cord-259603-bh198xgl	598	13	viral	viral	JJ
cord-259603-bh198xgl	598	14	RNA	RNA	NNP
cord-259603-bh198xgl	598	15	synthesis	synthesis	NN
cord-259603-bh198xgl	598	16	.	.	.
cord-259603-bh198xgl	599	1	Its	-PRON-	PRP$
cord-259603-bh198xgl	599	2	N	n	CD
cord-259603-bh198xgl	599	3	-	-	HYPH
cord-259603-bh198xgl	599	4	terminal	terminal	NN
cord-259603-bh198xgl	599	5	exonuclease	exonuclease	NN
cord-259603-bh198xgl	599	6	(	(	-LRB-
cord-259603-bh198xgl	599	7	ExoN	ExoN	NNP
cord-259603-bh198xgl	599	8	)	)	-RRB-
cord-259603-bh198xgl	599	9	domain	domain	NN
cord-259603-bh198xgl	599	10	(	(	-LRB-
cord-259603-bh198xgl	599	11	Minskaia	Minskaia	NNP
cord-259603-bh198xgl	599	12	et	et	NNP
cord-259603-bh198xgl	599	13	al	al	NNP
cord-259603-bh198xgl	599	14	.	.	NNP
cord-259603-bh198xgl	599	15	,	,	,
cord-259603-bh198xgl	599	16	2006	2006	CD
cord-259603-bh198xgl	599	17	;	;	:
cord-259603-bh198xgl	599	18	Snijder	Snijder	NNP
cord-259603-bh198xgl	599	19	et	et	NNP
cord-259603-bh198xgl	599	20	al	al	NNP
cord-259603-bh198xgl	599	21	.	.	NNP
cord-259603-bh198xgl	599	22	,	,	,
cord-259603-bh198xgl	599	23	2003	2003	CD
cord-259603-bh198xgl	599	24	)	)	-RRB-
cord-259603-bh198xgl	599	25	,	,	,
cord-259603-bh198xgl	599	26	which	which	WDT
cord-259603-bh198xgl	599	27	is	be	VBZ
cord-259603-bh198xgl	599	28	thought	think	VBN
cord-259603-bh198xgl	599	29	to	to	TO
cord-259603-bh198xgl	599	30	promote	promote	VB
cord-259603-bh198xgl	599	31	the	the	DT
cord-259603-bh198xgl	599	32	fidelity	fidelity	NNP
cord-259603-bh198xgl	599	33	of	of	IN
cord-259603-bh198xgl	599	34	CoV	CoV	NNP
cord-259603-bh198xgl	599	35	RNA	RNA	NNP
cord-259603-bh198xgl	599	36	synthesis	synthesis	NN
cord-259603-bh198xgl	599	37	,	,	,
cord-259603-bh198xgl	599	38	will	will	MD
cord-259603-bh198xgl	599	39	be	be	VB
cord-259603-bh198xgl	599	40	discussed	discuss	VBN
cord-259603-bh198xgl	599	41	in	in	IN
cord-259603-bh198xgl	599	42	more	more	JJR
cord-259603-bh198xgl	599	43	detail	detail	NN
cord-259603-bh198xgl	599	44	in	in	IN
cord-259603-bh198xgl	599	45	Section	section	NN
cord-259603-bh198xgl	599	46	6	6	CD
cord-259603-bh198xgl	599	47	.	.	.
cord-259603-bh198xgl	600	1	The	the	DT
cord-259603-bh198xgl	600	2	C	c	NN
cord-259603-bh198xgl	600	3	-	-	HYPH
cord-259603-bh198xgl	600	4	terminal	terminal	NN
cord-259603-bh198xgl	600	5	part	part	NN
cord-259603-bh198xgl	600	6	of	of	IN
cord-259603-bh198xgl	600	7	nsp14	nsp14	NNP
cord-259603-bh198xgl	600	8	carries	carry	VBZ
cord-259603-bh198xgl	600	9	an	an	DT
cord-259603-bh198xgl	600	10	AdoMet	AdoMet	NNP
cord-259603-bh198xgl	600	11	-	-	HYPH
cord-259603-bh198xgl	600	12	dependent	dependent	JJ
cord-259603-bh198xgl	600	13	guanosine	guanosine	NN
cord-259603-bh198xgl	600	14	N7-MTase	n7-mtase	NN
cord-259603-bh198xgl	600	15	activity	activity	NN
cord-259603-bh198xgl	600	16	.	.	.
cord-259603-bh198xgl	601	1	Interestingly	interestingly	RB
cord-259603-bh198xgl	601	2	,	,	,
cord-259603-bh198xgl	601	3	as	as	IN
cord-259603-bh198xgl	601	4	in	in	IN
cord-259603-bh198xgl	601	5	the	the	DT
cord-259603-bh198xgl	601	6	case	case	NN
cord-259603-bh198xgl	601	7	of	of	IN
cord-259603-bh198xgl	601	8	the	the	DT
cord-259603-bh198xgl	601	9	GTase	GTase	NNP
cord-259603-bh198xgl	601	10	(	(	-LRB-
cord-259603-bh198xgl	601	11	see	see	VB
cord-259603-bh198xgl	601	12	earlier	early	RBR
cord-259603-bh198xgl	601	13	)	)	-RRB-
cord-259603-bh198xgl	601	14	,	,	,
cord-259603-bh198xgl	601	15	bioinformatics	bioinformatics	NN
cord-259603-bh198xgl	601	16	analyses	analysis	NNS
cord-259603-bh198xgl	601	17	of	of	IN
cord-259603-bh198xgl	601	18	CoV	CoV	NNP
cord-259603-bh198xgl	601	19	genome	genome	NN
cord-259603-bh198xgl	601	20	sequences	sequence	NNS
cord-259603-bh198xgl	601	21	failed	fail	VBD
cord-259603-bh198xgl	601	22	to	to	TO
cord-259603-bh198xgl	601	23	identify	identify	VB
cord-259603-bh198xgl	601	24	proteins	protein	NNS
cord-259603-bh198xgl	601	25	or	or	CC
cord-259603-bh198xgl	601	26	protein	protein	NN
cord-259603-bh198xgl	601	27	domains	domain	NNS
cord-259603-bh198xgl	601	28	related	relate	VBN
cord-259603-bh198xgl	601	29	to	to	IN
cord-259603-bh198xgl	601	30	cellular	cellular	JJ
cord-259603-bh198xgl	601	31	and/or	and/or	CC
cord-259603-bh198xgl	601	32	viral	viral	JJ
cord-259603-bh198xgl	601	33	N7-MTases	n7-mtase	NNS
cord-259603-bh198xgl	601	34	,	,	,
cord-259603-bh198xgl	601	35	again	again	RB
cord-259603-bh198xgl	601	36	illustrating	illustrate	VBG
cord-259603-bh198xgl	601	37	the	the	DT
cord-259603-bh198xgl	601	38	significant	significant	JJ
cord-259603-bh198xgl	601	39	divergence	divergence	NN
cord-259603-bh198xgl	601	40	of	of	IN
cord-259603-bh198xgl	601	41	nidoviruses	nidoviruse	NNS
cord-259603-bh198xgl	601	42	from	from	IN
cord-259603-bh198xgl	601	43	other	other	JJ
cord-259603-bh198xgl	601	44	viral	viral	JJ
cord-259603-bh198xgl	601	45	and	and	CC
cord-259603-bh198xgl	601	46	cellular	cellular	JJ
cord-259603-bh198xgl	601	47	systems	system	NNS
cord-259603-bh198xgl	601	48	.	.	.
cord-259603-bh198xgl	602	1	However	however	RB
cord-259603-bh198xgl	602	2	,	,	,
cord-259603-bh198xgl	602	3	using	use	VBG
cord-259603-bh198xgl	602	4	a	a	DT
cord-259603-bh198xgl	602	5	trans	trans	JJ
cord-259603-bh198xgl	602	6	-	-	NN
cord-259603-bh198xgl	602	7	complementation	complementation	JJ
cord-259603-bh198xgl	602	8	assay	assay	NN
cord-259603-bh198xgl	602	9	and	and	CC
cord-259603-bh198xgl	602	10	a	a	DT
cord-259603-bh198xgl	602	11	yeast	yeast	NN
cord-259603-bh198xgl	602	12	strain	strain	NN
cord-259603-bh198xgl	602	13	lacking	lack	VBG
cord-259603-bh198xgl	602	14	the	the	DT
cord-259603-bh198xgl	602	15	abd1	abd1	CD
cord-259603-bh198xgl	602	16	(	(	-LRB-
cord-259603-bh198xgl	602	17	N7-MTase	N7-MTase	NNP
cord-259603-bh198xgl	602	18	)	)	-RRB-
cord-259603-bh198xgl	602	19	gene	gene	NN
cord-259603-bh198xgl	602	20	,	,	,
cord-259603-bh198xgl	602	21	Guo	Guo	NNP
cord-259603-bh198xgl	602	22	et	et	FW
cord-259603-bh198xgl	602	23	al	al	NNP
cord-259603-bh198xgl	602	24	.	.	NNP
cord-259603-bh198xgl	602	25	discovered	discover	VBD
cord-259603-bh198xgl	602	26	a	a	DT
cord-259603-bh198xgl	602	27	SARS	SARS	NNP
cord-259603-bh198xgl	602	28	-	-	HYPH
cord-259603-bh198xgl	602	29	CoV	CoV	NNP
cord-259603-bh198xgl	602	30	nsp14-associated	nsp14-associate	VBN
cord-259603-bh198xgl	603	1	N7-MTase	n7-mtase	NN
cord-259603-bh198xgl	603	2	activity	activity	NN
cord-259603-bh198xgl	604	1	(	(	-LRB-
cord-259603-bh198xgl	604	2	Chen	Chen	NNP
cord-259603-bh198xgl	604	3	et	et	NNP
cord-259603-bh198xgl	604	4	al	al	NNP
cord-259603-bh198xgl	604	5	.	.	.
cord-259603-bh198xgl	605	1	,	,	,
cord-259603-bh198xgl	605	2	2009c	2009c	CD
cord-259603-bh198xgl	605	3	)	)	-RRB-
cord-259603-bh198xgl	605	4	by	by	IN
cord-259603-bh198xgl	605	5	demonstrating	demonstrate	VBG
cord-259603-bh198xgl	605	6	that	that	IN
cord-259603-bh198xgl	605	7	the	the	DT
cord-259603-bh198xgl	605	8	protein	protein	NN
cord-259603-bh198xgl	605	9	was	be	VBD
cord-259603-bh198xgl	605	10	able	able	JJ
cord-259603-bh198xgl	605	11	to	to	TO
cord-259603-bh198xgl	605	12	restore	restore	VB
cord-259603-bh198xgl	605	13	the	the	DT
cord-259603-bh198xgl	605	14	growth	growth	NN
cord-259603-bh198xgl	605	15	of	of	IN
cord-259603-bh198xgl	605	16	the	the	DT
cord-259603-bh198xgl	605	17	△	△	NNP
cord-259603-bh198xgl	605	18	abd1	abd1	CD
cord-259603-bh198xgl	605	19	yeast	yeast	NN
cord-259603-bh198xgl	605	20	mutant	mutant	NN
cord-259603-bh198xgl	605	21	.	.	.
cord-259603-bh198xgl	606	1	They	-PRON-	PRP
cord-259603-bh198xgl	606	2	also	also	RB
cord-259603-bh198xgl	606	3	showed	show	VBD
cord-259603-bh198xgl	606	4	that	that	IN
cord-259603-bh198xgl	606	5	a	a	DT
cord-259603-bh198xgl	606	6	range	range	NN
cord-259603-bh198xgl	606	7	of	of	IN
cord-259603-bh198xgl	606	8	alphacoronavirus	alphacoronavirus	NNP
cord-259603-bh198xgl	606	9	nsp14	nsp14	.
cord-259603-bh198xgl	606	10	homologs	homolog	NNS
cord-259603-bh198xgl	606	11	were	be	VBD
cord-259603-bh198xgl	606	12	able	able	JJ
cord-259603-bh198xgl	606	13	to	to	TO
cord-259603-bh198xgl	606	14	complement	complement	VB
cord-259603-bh198xgl	606	15	the	the	DT
cord-259603-bh198xgl	606	16	defect	defect	NN
cord-259603-bh198xgl	606	17	of	of	IN
cord-259603-bh198xgl	606	18	the	the	DT
cord-259603-bh198xgl	606	19	△	△	NNP
cord-259603-bh198xgl	606	20	abd1	abd1	CD
cord-259603-bh198xgl	606	21	yeast	yeast	NN
cord-259603-bh198xgl	606	22	strain	strain	NN
cord-259603-bh198xgl	606	23	.	.	.
cord-259603-bh198xgl	607	1	The	the	DT
cord-259603-bh198xgl	607	2	N7-MTase	N7-MTase	NNP
cord-259603-bh198xgl	607	3	activity	activity	NN
cord-259603-bh198xgl	607	4	of	of	IN
cord-259603-bh198xgl	607	5	nsp14	nsp14	NNP
cord-259603-bh198xgl	607	6	was	be	VBD
cord-259603-bh198xgl	607	7	subsequently	subsequently	RB
cord-259603-bh198xgl	607	8	confirmed	confirm	VBN
cord-259603-bh198xgl	607	9	and	and	CC
cord-259603-bh198xgl	607	10	characterized	characterize	VBN
cord-259603-bh198xgl	607	11	using	use	VBG
cord-259603-bh198xgl	607	12	purified	purify	VBN
cord-259603-bh198xgl	607	13	recombinant	recombinant	JJ
cord-259603-bh198xgl	607	14	enzymes	enzyme	NNS
cord-259603-bh198xgl	607	15	(	(	-LRB-
cord-259603-bh198xgl	607	16	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	607	17	et	et	NNP
cord-259603-bh198xgl	607	18	al	al	NNP
cord-259603-bh198xgl	607	19	.	.	NNP
cord-259603-bh198xgl	607	20	,	,	,
cord-259603-bh198xgl	607	21	2012	2012	CD
cord-259603-bh198xgl	607	22	;	;	.
cord-259603-bh198xgl	608	1	Chen	Chen	NNP
cord-259603-bh198xgl	608	2	et	et	NNP
cord-259603-bh198xgl	608	3	al	al	NNP
cord-259603-bh198xgl	608	4	.	.	NNP
cord-259603-bh198xgl	608	5	,	,	,
cord-259603-bh198xgl	608	6	2009c	2009c	CD
cord-259603-bh198xgl	608	7	)	)	-RRB-
cord-259603-bh198xgl	608	8	.	.	.
cord-259603-bh198xgl	609	1	The	the	DT
cord-259603-bh198xgl	609	2	SARS	SARS	NNP
cord-259603-bh198xgl	609	3	-	-	HYPH
cord-259603-bh198xgl	609	4	CoV	CoV	NNP
cord-259603-bh198xgl	609	5	N7-MTase	N7-MTase	NNP
cord-259603-bh198xgl	609	6	was	be	VBD
cord-259603-bh198xgl	609	7	shown	show	VBN
cord-259603-bh198xgl	609	8	to	to	TO
cord-259603-bh198xgl	609	9	methylate	methylate	VB
cord-259603-bh198xgl	609	10	5	5	CD
cord-259603-bh198xgl	609	11	0	0	CD
cord-259603-bh198xgl	609	12	cap	cap	NN
cord-259603-bh198xgl	609	13	structures	structure	NNS
cord-259603-bh198xgl	609	14	in	in	IN
cord-259603-bh198xgl	609	15	a	a	DT
cord-259603-bh198xgl	609	16	sequenceindependent	sequenceindependent	NN
cord-259603-bh198xgl	609	17	manner	manner	NN
cord-259603-bh198xgl	609	18	using	use	VBG
cord-259603-bh198xgl	609	19	a	a	DT
cord-259603-bh198xgl	609	20	range	range	NN
cord-259603-bh198xgl	609	21	of	of	IN
cord-259603-bh198xgl	609	22	RNAs	rna	NNS
cord-259603-bh198xgl	610	1	and	and	CC
cord-259603-bh198xgl	610	2	it	-PRON-	PRP
cord-259603-bh198xgl	610	3	also	also	RB
cord-259603-bh198xgl	610	4	proved	prove	VBD
cord-259603-bh198xgl	610	5	to	to	TO
cord-259603-bh198xgl	610	6	be	be	VB
cord-259603-bh198xgl	610	7	active	active	JJ
cord-259603-bh198xgl	610	8	on	on	IN
cord-259603-bh198xgl	610	9	cap	cap	NN
cord-259603-bh198xgl	610	10	analogues	analogue	NNS
cord-259603-bh198xgl	610	11	and	and	CC
cord-259603-bh198xgl	610	12	GTP	GTP	NNP
cord-259603-bh198xgl	610	13	(	(	-LRB-
cord-259603-bh198xgl	610	14	Jin	Jin	NNP
cord-259603-bh198xgl	610	15	et	et	NNP
cord-259603-bh198xgl	610	16	al	al	NNP
cord-259603-bh198xgl	610	17	.	.	NNP
cord-259603-bh198xgl	610	18	,	,	,
cord-259603-bh198xgl	610	19	2013	2013	CD
cord-259603-bh198xgl	610	20	)	)	-RRB-
cord-259603-bh198xgl	610	21	,	,	,
cord-259603-bh198xgl	610	22	corroborating	corroborate	VBG
cord-259603-bh198xgl	610	23	the	the	DT
cord-259603-bh198xgl	610	24	trans	trans	JJ
cord-259603-bh198xgl	610	25	-	-	JJ
cord-259603-bh198xgl	610	26	complementation	complementation	NN
cord-259603-bh198xgl	610	27	experiments	experiment	NNS
cord-259603-bh198xgl	610	28	in	in	IN
cord-259603-bh198xgl	610	29	yeast	yeast	NN
cord-259603-bh198xgl	610	30	in	in	IN
cord-259603-bh198xgl	610	31	which	which	WDT
cord-259603-bh198xgl	610	32	rescue	rescue	NN
cord-259603-bh198xgl	610	33	required	require	VBD
cord-259603-bh198xgl	610	34	efficient	efficient	JJ
cord-259603-bh198xgl	610	35	methylation	methylation	NN
cord-259603-bh198xgl	610	36	of	of	IN
cord-259603-bh198xgl	610	37	a	a	DT
cord-259603-bh198xgl	610	38	wide	wide	JJ
cord-259603-bh198xgl	610	39	range	range	NN
cord-259603-bh198xgl	610	40	of	of	IN
cord-259603-bh198xgl	610	41	cellular	cellular	JJ
cord-259603-bh198xgl	610	42	RNAs	rna	NNS
cord-259603-bh198xgl	610	43	.	.	.
cord-259603-bh198xgl	611	1	In	in	IN
cord-259603-bh198xgl	611	2	contrast	contrast	NN
cord-259603-bh198xgl	611	3	to	to	IN
cord-259603-bh198xgl	611	4	the	the	DT
cord-259603-bh198xgl	611	5	ExoN	ExoN	NNP
cord-259603-bh198xgl	611	6	activity	activity	NN
cord-259603-bh198xgl	611	7	,	,	,
cord-259603-bh198xgl	611	8	the	the	DT
cord-259603-bh198xgl	611	9	in	in	FW
cord-259603-bh198xgl	611	10	vitro	vitro	FW
cord-259603-bh198xgl	611	11	N7-MTase	n7-mtase	NN
cord-259603-bh198xgl	611	12	activity	activity	NN
cord-259603-bh198xgl	611	13	was	be	VBD
cord-259603-bh198xgl	611	14	not	not	RB
cord-259603-bh198xgl	611	15	found	find	VBN
cord-259603-bh198xgl	611	16	to	to	TO
cord-259603-bh198xgl	611	17	be	be	VB
cord-259603-bh198xgl	611	18	affected	affect	VBN
cord-259603-bh198xgl	611	19	by	by	IN
cord-259603-bh198xgl	611	20	interactions	interaction	NNS
cord-259603-bh198xgl	611	21	with	with	IN
cord-259603-bh198xgl	611	22	nsp10	nsp10	XX
cord-259603-bh198xgl	611	23	(	(	-LRB-
cord-259603-bh198xgl	611	24	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	611	25	et	et	NNP
cord-259603-bh198xgl	611	26	al	al	NNP
cord-259603-bh198xgl	611	27	.	.	NNP
cord-259603-bh198xgl	611	28	,	,	,
cord-259603-bh198xgl	611	29	2010	2010	CD
cord-259603-bh198xgl	611	30	)	)	-RRB-
cord-259603-bh198xgl	611	31	.	.	.
cord-259603-bh198xgl	612	1	The	the	DT
cord-259603-bh198xgl	612	2	N7-MTase	N7-MTase	NNP
cord-259603-bh198xgl	612	3	domain	domain	NN
cord-259603-bh198xgl	612	4	was	be	VBD
cord-259603-bh198xgl	612	5	further	further	RB
cord-259603-bh198xgl	612	6	characterized	characterize	VBN
cord-259603-bh198xgl	612	7	by	by	IN
cord-259603-bh198xgl	612	8	alanine	alanine	NN
cord-259603-bh198xgl	612	9	scanning	scanning	NN
cord-259603-bh198xgl	612	10	mutagenesis	mutagenesis	NN
cord-259603-bh198xgl	612	11	and	and	CC
cord-259603-bh198xgl	612	12	key	key	JJ
cord-259603-bh198xgl	612	13	residues	residue	NNS
cord-259603-bh198xgl	612	14	for	for	IN
cord-259603-bh198xgl	612	15	enzymatic	enzymatic	JJ
cord-259603-bh198xgl	612	16	activity	activity	NN
cord-259603-bh198xgl	612	17	were	be	VBD
cord-259603-bh198xgl	612	18	identified	identify	VBN
cord-259603-bh198xgl	613	1	(	(	-LRB-
cord-259603-bh198xgl	613	2	Chen	Chen	NNP
cord-259603-bh198xgl	613	3	et	et	NNP
cord-259603-bh198xgl	613	4	al	al	NNP
cord-259603-bh198xgl	613	5	.	.	.
cord-259603-bh198xgl	614	1	,	,	,
cord-259603-bh198xgl	614	2	2009c	2009c	CD
cord-259603-bh198xgl	614	3	)	)	-RRB-
cord-259603-bh198xgl	614	4	including	include	VBG
cord-259603-bh198xgl	614	5	10	10	CD
cord-259603-bh198xgl	614	6	crucial	crucial	JJ
cord-259603-bh198xgl	614	7	residues	residue	NNS
cord-259603-bh198xgl	614	8	distributed	distribute	VBN
cord-259603-bh198xgl	614	9	throughout	throughout	IN
cord-259603-bh198xgl	614	10	the	the	DT
cord-259603-bh198xgl	614	11	domain	domain	NN
cord-259603-bh198xgl	614	12	and	and	CC
cord-259603-bh198xgl	614	13	two	two	CD
cord-259603-bh198xgl	614	14	clusters	cluster	NNS
cord-259603-bh198xgl	614	15	of	of	IN
cord-259603-bh198xgl	614	16	residues	residue	NNS
cord-259603-bh198xgl	614	17	essential	essential	JJ
cord-259603-bh198xgl	614	18	for	for	IN
cord-259603-bh198xgl	614	19	MTase	MTase	NNP
cord-259603-bh198xgl	614	20	activity	activity	NN
cord-259603-bh198xgl	614	21	(	(	-LRB-
cord-259603-bh198xgl	614	22	Fig	Fig	NNP
cord-259603-bh198xgl	614	23	.	.	.
cord-259603-bh198xgl	614	24	5	5	CD
cord-259603-bh198xgl	614	25	)	)	-RRB-
cord-259603-bh198xgl	614	26	.	.	.
cord-259603-bh198xgl	615	1	The	the	DT
cord-259603-bh198xgl	615	2	first	first	JJ
cord-259603-bh198xgl	615	3	cluster	cluster	NN
cord-259603-bh198xgl	615	4	(	(	-LRB-
cord-259603-bh198xgl	615	5	nsp14	nsp14	NN
cord-259603-bh198xgl	615	6	residues	residue	NNS
cord-259603-bh198xgl	615	7	331	331	CD
cord-259603-bh198xgl	615	8	-	-	SYM
cord-259603-bh198xgl	615	9	336	336	CD
cord-259603-bh198xgl	615	10	)	)	-RRB-
cord-259603-bh198xgl	615	11	corresponds	correspond	VBZ
cord-259603-bh198xgl	615	12	to	to	IN
cord-259603-bh198xgl	615	13	the	the	DT
cord-259603-bh198xgl	615	14	DXGXPXA	DXGXPXA	NNP
cord-259603-bh198xgl	615	15	motif	motif	NN
cord-259603-bh198xgl	615	16	of	of	IN
cord-259603-bh198xgl	615	17	the	the	DT
cord-259603-bh198xgl	615	18	AdoMet	AdoMet	NNP
cord-259603-bh198xgl	615	19	-	-	HYPH
cord-259603-bh198xgl	615	20	binding	bind	VBG
cord-259603-bh198xgl	615	21	site	site	NN
cord-259603-bh198xgl	615	22	.	.	.
cord-259603-bh198xgl	616	1	In	in	IN
cord-259603-bh198xgl	616	2	cross	cross	JJ
cord-259603-bh198xgl	616	3	-	-	JJ
cord-259603-bh198xgl	616	4	linking	link	VBG
cord-259603-bh198xgl	616	5	experiments	experiment	NNS
cord-259603-bh198xgl	616	6	,	,	,
cord-259603-bh198xgl	616	7	mutations	mutation	NNS
cord-259603-bh198xgl	616	8	in	in	IN
cord-259603-bh198xgl	616	9	this	this	DT
cord-259603-bh198xgl	616	10	motif	motif	NN
cord-259603-bh198xgl	616	11	strongly	strongly	RB
cord-259603-bh198xgl	616	12	decreased	decrease	VBD
cord-259603-bh198xgl	616	13	the	the	DT
cord-259603-bh198xgl	616	14	binding	binding	NN
cord-259603-bh198xgl	616	15	of	of	IN
cord-259603-bh198xgl	616	16	3	3	CD
cord-259603-bh198xgl	616	17	H	h	NN
cord-259603-bh198xgl	616	18	-	-	HYPH
cord-259603-bh198xgl	616	19	labeled	label	VBN
cord-259603-bh198xgl	616	20	AdoMet	AdoMet	NNP
cord-259603-bh198xgl	616	21	.	.	.
cord-259603-bh198xgl	617	1	The	the	DT
cord-259603-bh198xgl	617	2	role	role	NN
cord-259603-bh198xgl	617	3	of	of	IN
cord-259603-bh198xgl	617	4	the	the	DT
cord-259603-bh198xgl	617	5	second	second	JJ
cord-259603-bh198xgl	617	6	cluster	cluster	NN
cord-259603-bh198xgl	617	7	,	,	,
cord-259603-bh198xgl	617	8	between	between	IN
cord-259603-bh198xgl	617	9	residues	residue	NNS
cord-259603-bh198xgl	617	10	414	414	CD
cord-259603-bh198xgl	617	11	and	and	CC
cord-259603-bh198xgl	617	12	428	428	CD
cord-259603-bh198xgl	617	13	,	,	,
cord-259603-bh198xgl	617	14	was	be	VBD
cord-259603-bh198xgl	617	15	revealed	reveal	VBN
cord-259603-bh198xgl	617	16	by	by	IN
cord-259603-bh198xgl	617	17	X	x	NN
cord-259603-bh198xgl	617	18	-	-	NN
cord-259603-bh198xgl	617	19	ray	ray	JJ
cord-259603-bh198xgl	617	20	structure	structure	NN
cord-259603-bh198xgl	617	21	analysis	analysis	NN
cord-259603-bh198xgl	617	22	of	of	IN
cord-259603-bh198xgl	617	23	a	a	DT
cord-259603-bh198xgl	617	24	SARS	SARS	NNP
cord-259603-bh198xgl	617	25	-	-	HYPH
cord-259603-bh198xgl	617	26	CoV	CoV	NNP
cord-259603-bh198xgl	617	27	nsp10	nsp10	NNP
cord-259603-bh198xgl	617	28	/	/	SYM
cord-259603-bh198xgl	617	29	nsp14	nsp14	CD
cord-259603-bh198xgl	617	30	complex	complex	NN
cord-259603-bh198xgl	617	31	expressed	express	VBN
cord-259603-bh198xgl	617	32	in	in	IN
cord-259603-bh198xgl	617	33	E.	E.	NNP
cord-259603-bh198xgl	617	34	coli	coli	NNS
cord-259603-bh198xgl	617	35	(	(	-LRB-
cord-259603-bh198xgl	617	36	Fig	Fig	NNP
cord-259603-bh198xgl	617	37	.	.	.
cord-259603-bh198xgl	617	38	6	6	CD
cord-259603-bh198xgl	617	39	)	)	-RRB-
cord-259603-bh198xgl	618	1	(	(	-LRB-
cord-259603-bh198xgl	618	2	Ma	Ma	NNP
cord-259603-bh198xgl	618	3	et	et	NNP
cord-259603-bh198xgl	618	4	al	al	NNP
cord-259603-bh198xgl	618	5	.	.	NNP
cord-259603-bh198xgl	618	6	,	,	,
cord-259603-bh198xgl	618	7	2015	2015	CD
cord-259603-bh198xgl	618	8	)	)	-RRB-
cord-259603-bh198xgl	618	9	.	.	.
cord-259603-bh198xgl	619	1	These	these	DT
cord-259603-bh198xgl	619	2	residues	residue	NNS
cord-259603-bh198xgl	619	3	form	form	VBP
cord-259603-bh198xgl	619	4	a	a	DT
cord-259603-bh198xgl	619	5	constricted	constricted	JJ
cord-259603-bh198xgl	619	6	pocket	pocket	NN
cord-259603-bh198xgl	619	7	that	that	WDT
cord-259603-bh198xgl	619	8	holds	hold	VBZ
cord-259603-bh198xgl	619	9	the	the	DT
cord-259603-bh198xgl	619	10	cap	cap	NN
cord-259603-bh198xgl	619	11	structure	structure	NN
cord-259603-bh198xgl	619	12	(	(	-LRB-
cord-259603-bh198xgl	619	13	GpppA	GpppA	NNP
cord-259603-bh198xgl	619	14	)	)	-RRB-
cord-259603-bh198xgl	619	15	between	between	IN
cord-259603-bh198xgl	619	16	two	two	CD
cord-259603-bh198xgl	619	17	β	β	NN
cord-259603-bh198xgl	619	18	-	-	HYPH
cord-259603-bh198xgl	619	19	strands	strand	NNS
cord-259603-bh198xgl	619	20	(	(	-LRB-
cord-259603-bh198xgl	619	21	β1	β1	NNP
cord-259603-bh198xgl	619	22	and	and	CC
cord-259603-bh198xgl	619	23	β2	β2	NNP
cord-259603-bh198xgl	619	24	)	)	-RRB-
cord-259603-bh198xgl	619	25	and	and	CC
cord-259603-bh198xgl	619	26	helix	helix	NN
cord-259603-bh198xgl	619	27	1	1	CD
cord-259603-bh198xgl	619	28	,	,	,
cord-259603-bh198xgl	619	29	placing	place	VBG
cord-259603-bh198xgl	619	30	the	the	DT
cord-259603-bh198xgl	619	31	N7	N7	NNP
cord-259603-bh198xgl	619	32	position	position	NN
cord-259603-bh198xgl	619	33	of	of	IN
cord-259603-bh198xgl	619	34	the	the	DT
cord-259603-bh198xgl	619	35	guanine	guanine	NN
cord-259603-bh198xgl	619	36	in	in	IN
cord-259603-bh198xgl	619	37	close	close	JJ
cord-259603-bh198xgl	619	38	proximity	proximity	NN
cord-259603-bh198xgl	619	39	of	of	IN
cord-259603-bh198xgl	619	40	AdoMet	AdoMet	NNP
cord-259603-bh198xgl	619	41	and	and	CC
cord-259603-bh198xgl	619	42	ready	ready	JJ
cord-259603-bh198xgl	619	43	for	for	IN
cord-259603-bh198xgl	619	44	methyl	methyl	NN
cord-259603-bh198xgl	619	45	transfer	transfer	NN
cord-259603-bh198xgl	619	46	using	use	VBG
cord-259603-bh198xgl	619	47	an	an	DT
cord-259603-bh198xgl	619	48	in	in	IN
cord-259603-bh198xgl	619	49	-	-	HYPH
cord-259603-bh198xgl	619	50	line	line	NN
cord-259603-bh198xgl	619	51	mechanism	mechanism	NN
cord-259603-bh198xgl	619	52	.	.	.
cord-259603-bh198xgl	620	1	,	,	,
cord-259603-bh198xgl	620	2	and	and	CC
cord-259603-bh198xgl	620	3	IBV	IBV	NNP
cord-259603-bh198xgl	620	4	(	(	-LRB-
cord-259603-bh198xgl	620	5	genus	genus	NN
cord-259603-bh198xgl	620	6	Gammacoronavirus	Gammacoronavirus	NNP
cord-259603-bh198xgl	620	7	)	)	-RRB-
cord-259603-bh198xgl	620	8	.	.	.
cord-259603-bh198xgl	621	1	The	the	DT
cord-259603-bh198xgl	621	2	alignment	alignment	NN
cord-259603-bh198xgl	621	3	was	be	VBD
cord-259603-bh198xgl	621	4	generated	generate	VBN
cord-259603-bh198xgl	621	5	using	use	VBG
cord-259603-bh198xgl	621	6	Clustal	Clustal	NNP
cord-259603-bh198xgl	621	7	Omega	Omega	NNP
cord-259603-bh198xgl	621	8	(	(	-LRB-
cord-259603-bh198xgl	621	9	Sievers	Sievers	NNP
cord-259603-bh198xgl	621	10	et	et	NNP
cord-259603-bh198xgl	621	11	al	al	NNP
cord-259603-bh198xgl	621	12	.	.	NNP
cord-259603-bh198xgl	621	13	,	,	,
cord-259603-bh198xgl	621	14	2011	2011	CD
cord-259603-bh198xgl	621	15	)	)	-RRB-
cord-259603-bh198xgl	621	16	and	and	CC
cord-259603-bh198xgl	621	17	rendered	render	VBN
cord-259603-bh198xgl	621	18	using	use	VBG
cord-259603-bh198xgl	621	19	ESPript	ESPript	NNP
cord-259603-bh198xgl	621	20	version	version	NN
cord-259603-bh198xgl	621	21	3.0	3.0	CD
cord-259603-bh198xgl	621	22	(	(	-LRB-
cord-259603-bh198xgl	621	23	Robert	Robert	NNP
cord-259603-bh198xgl	621	24	and	and	CC
cord-259603-bh198xgl	621	25	Gouet	Gouet	NNP
cord-259603-bh198xgl	621	26	,	,	,
cord-259603-bh198xgl	621	27	2014	2014	CD
cord-259603-bh198xgl	621	28	)	)	-RRB-
cord-259603-bh198xgl	621	29	.	.	.
cord-259603-bh198xgl	622	1	Conserved	conserved	JJ
cord-259603-bh198xgl	622	2	ExoN	ExoN	NNP
cord-259603-bh198xgl	622	3	motifs	motif	NNS
cord-259603-bh198xgl	623	1	I	-PRON-	PRP
cord-259603-bh198xgl	623	2	,	,	,
cord-259603-bh198xgl	623	3	II	II	NNP
cord-259603-bh198xgl	623	4	,	,	,
cord-259603-bh198xgl	623	5	and	and	CC
cord-259603-bh198xgl	623	6	III	III	NNP
cord-259603-bh198xgl	623	7	and	and	CC
cord-259603-bh198xgl	623	8	clusters	cluster	NNS
cord-259603-bh198xgl	623	9	of	of	IN
cord-259603-bh198xgl	623	10	residues	residue	NNS
cord-259603-bh198xgl	623	11	involved	involve	VBN
cord-259603-bh198xgl	623	12	in	in	IN
cord-259603-bh198xgl	623	13	SAM	SAM	NNP
cord-259603-bh198xgl	623	14	binding	bind	VBG
cord-259603-bh198xgl	623	15	and	and	CC
cord-259603-bh198xgl	623	16	N7-MTase	N7-MTase	NNP
cord-259603-bh198xgl	623	17	activity	activity	NN
cord-259603-bh198xgl	623	18	(	(	-LRB-
cord-259603-bh198xgl	623	19	1	1	CD
cord-259603-bh198xgl	623	20	and	and	CC
cord-259603-bh198xgl	623	21	2	2	CD
cord-259603-bh198xgl	623	22	)	)	-RRB-
cord-259603-bh198xgl	623	23	are	be	VBP
cord-259603-bh198xgl	623	24	highlighted	highlight	VBN
cord-259603-bh198xgl	623	25	in	in	IN
cord-259603-bh198xgl	623	26	gray	gray	JJ
cord-259603-bh198xgl	623	27	.	.	.
cord-259603-bh198xgl	624	1	Catalytic	catalytic	JJ
cord-259603-bh198xgl	624	2	residues	residue	NNS
cord-259603-bh198xgl	624	3	of	of	IN
cord-259603-bh198xgl	624	4	ExoN	ExoN	NNP
cord-259603-bh198xgl	624	5	and	and	CC
cord-259603-bh198xgl	624	6	residues	residue	NNS
cord-259603-bh198xgl	624	7	involved	involve	VBN
cord-259603-bh198xgl	624	8	in	in	IN
cord-259603-bh198xgl	624	9	the	the	DT
cord-259603-bh198xgl	624	10	formation	formation	NN
cord-259603-bh198xgl	624	11	of	of	IN
cord-259603-bh198xgl	624	12	zinc	zinc	NN
cord-259603-bh198xgl	624	13	fingers	finger	NNS
cord-259603-bh198xgl	624	14	are	be	VBP
cord-259603-bh198xgl	624	15	indicated	indicate	VBN
cord-259603-bh198xgl	624	16	by	by	IN
cord-259603-bh198xgl	624	17	asterisks	asterisk	NNS
cord-259603-bh198xgl	624	18	and	and	CC
cord-259603-bh198xgl	624	19	arrowheads	arrowhead	NNS
cord-259603-bh198xgl	624	20	,	,	,
cord-259603-bh198xgl	624	21	respectively	respectively	RB
cord-259603-bh198xgl	624	22	.	.	.
cord-259603-bh198xgl	625	1	Also	also	RB
cord-259603-bh198xgl	625	2	shown	show	VBN
cord-259603-bh198xgl	625	3	are	be	VBP
cord-259603-bh198xgl	625	4	the	the	DT
cord-259603-bh198xgl	625	5	secondary	secondary	JJ
cord-259603-bh198xgl	625	6	structure	structure	NN
cord-259603-bh198xgl	625	7	elements	element	NNS
cord-259603-bh198xgl	625	8	of	of	IN
cord-259603-bh198xgl	625	9	SARS	SARS	NNP
cord-259603-bh198xgl	625	10	-	-	HYPH
cord-259603-bh198xgl	625	11	CoV	CoV	NNP
cord-259603-bh198xgl	626	1	nsp14	nsp14	XX
cord-259603-bh198xgl	627	1	(	(	-LRB-
cord-259603-bh198xgl	627	2	pdb	pdb	NNP
cord-259603-bh198xgl	627	3	5C8S	5c8s	CD
cord-259603-bh198xgl	627	4	)	)	-RRB-
cord-259603-bh198xgl	627	5	and	and	CC
cord-259603-bh198xgl	627	6	the	the	DT
cord-259603-bh198xgl	627	7	border	border	NN
cord-259603-bh198xgl	627	8	between	between	IN
cord-259603-bh198xgl	627	9	the	the	DT
cord-259603-bh198xgl	627	10	N	n	CD
cord-259603-bh198xgl	627	11	-	-	HYPH
cord-259603-bh198xgl	627	12	terminal	terminal	NN
cord-259603-bh198xgl	627	13	ExoN	ExoN	NNP
cord-259603-bh198xgl	627	14	and	and	CC
cord-259603-bh198xgl	627	15	C	C	NNP
cord-259603-bh198xgl	627	16	-	-	HYPH
cord-259603-bh198xgl	627	17	terminal	terminal	NN
cord-259603-bh198xgl	627	18	N7-MT	N7-MT	NNP
cord-259603-bh198xgl	627	19	(	(	-LRB-
cord-259603-bh198xgl	627	20	NMT	NMT	NNP
cord-259603-bh198xgl	627	21	)	)	-RRB-
cord-259603-bh198xgl	627	22	domains	domain	NNS
cord-259603-bh198xgl	627	23	.	.	.
cord-259603-bh198xgl	628	1	The	the	DT
cord-259603-bh198xgl	628	2	structure	structure	NN
cord-259603-bh198xgl	628	3	also	also	RB
cord-259603-bh198xgl	628	4	revealed	reveal	VBD
cord-259603-bh198xgl	628	5	that	that	IN
cord-259603-bh198xgl	628	6	the	the	DT
cord-259603-bh198xgl	628	7	nsp14	nsp14	NNP
cord-259603-bh198xgl	628	8	N7-MTase	N7-MTase	NNP
cord-259603-bh198xgl	628	9	domain	domain	NN
cord-259603-bh198xgl	628	10	exhibits	exhibit	VBZ
cord-259603-bh198xgl	628	11	a	a	DT
cord-259603-bh198xgl	628	12	noncanonical	noncanonical	JJ
cord-259603-bh198xgl	628	13	MTase	mtase	NN
cord-259603-bh198xgl	628	14	fold	fold	VB
cord-259603-bh198xgl	628	15	.	.	.
cord-259603-bh198xgl	629	1	Whereas	whereas	IN
cord-259603-bh198xgl	629	2	the	the	DT
cord-259603-bh198xgl	629	3	canonical	canonical	JJ
cord-259603-bh198xgl	629	4	fold	fold	NN
cord-259603-bh198xgl	629	5	contains	contain	VBZ
cord-259603-bh198xgl	629	6	a	a	DT
cord-259603-bh198xgl	629	7	7-strand	7-strand	CD
cord-259603-bh198xgl	629	8	β	β	NN
cord-259603-bh198xgl	629	9	-	-	HYPH
cord-259603-bh198xgl	629	10	sheet	sheet	NN
cord-259603-bh198xgl	629	11	that	that	WDT
cord-259603-bh198xgl	629	12	is	be	VBZ
cord-259603-bh198xgl	629	13	commonly	commonly	RB
cord-259603-bh198xgl	629	14	present	present	JJ
cord-259603-bh198xgl	629	15	in	in	IN
cord-259603-bh198xgl	629	16	the	the	DT
cord-259603-bh198xgl	629	17	Rossman	Rossman	NNP
cord-259603-bh198xgl	629	18	fold	fold	VB
cord-259603-bh198xgl	629	19	,	,	,
cord-259603-bh198xgl	629	20	nsp14	nsp14	NNP
cord-259603-bh198xgl	629	21	contains	contain	VBZ
cord-259603-bh198xgl	629	22	only	only	RB
cord-259603-bh198xgl	629	23	a	a	DT
cord-259603-bh198xgl	629	24	5-strand	5-strand	CD
cord-259603-bh198xgl	629	25	β	β	NN
cord-259603-bh198xgl	629	26	-	-	HYPH
cord-259603-bh198xgl	629	27	sheet	sheet	NN
cord-259603-bh198xgl	629	28	and	and	CC
cord-259603-bh198xgl	629	29	an	an	DT
cord-259603-bh198xgl	629	30	insertion	insertion	NN
cord-259603-bh198xgl	629	31	of	of	IN
cord-259603-bh198xgl	629	32	a	a	DT
cord-259603-bh198xgl	629	33	3-strand	3-strand	CD
cord-259603-bh198xgl	629	34	antiparallel	antiparallel	RB
cord-259603-bh198xgl	629	35	β	β	NN
cord-259603-bh198xgl	629	36	-	-	HYPH
cord-259603-bh198xgl	629	37	sheet	sheet	NN
cord-259603-bh198xgl	629	38	between	between	IN
cord-259603-bh198xgl	629	39	β5	β5	NNP
cord-259603-bh198xgl	629	40	and	and	CC
cord-259603-bh198xgl	629	41	β6	β6	NNP
cord-259603-bh198xgl	629	42	.	.	.
cord-259603-bh198xgl	630	1	In	in	IN
cord-259603-bh198xgl	630	2	line	line	NN
cord-259603-bh198xgl	630	3	with	with	IN
cord-259603-bh198xgl	630	4	previous	previous	JJ
cord-259603-bh198xgl	630	5	mutagenesis	mutagenesis	NN
cord-259603-bh198xgl	630	6	data	datum	NNS
cord-259603-bh198xgl	630	7	(	(	-LRB-
cord-259603-bh198xgl	630	8	Chen	Chen	NNP
cord-259603-bh198xgl	630	9	et	et	NNP
cord-259603-bh198xgl	630	10	al	al	NNP
cord-259603-bh198xgl	630	11	.	.	NNP
cord-259603-bh198xgl	630	12	,	,	,
cord-259603-bh198xgl	630	13	2009c	2009c	CD
cord-259603-bh198xgl	630	14	)	)	-RRB-
cord-259603-bh198xgl	630	15	,	,	,
cord-259603-bh198xgl	630	16	the	the	DT
cord-259603-bh198xgl	630	17	Fig	Fig	NNP
cord-259603-bh198xgl	630	18	.	.	NNP
cord-259603-bh198xgl	630	19	6	6	CD
cord-259603-bh198xgl	630	20	Surface	surface	NN
cord-259603-bh198xgl	630	21	representation	representation	NN
cord-259603-bh198xgl	630	22	of	of	IN
cord-259603-bh198xgl	630	23	the	the	DT
cord-259603-bh198xgl	630	24	three	three	CD
cord-259603-bh198xgl	630	25	-	-	HYPH
cord-259603-bh198xgl	630	26	dimensional	dimensional	JJ
cord-259603-bh198xgl	630	27	structure	structure	NN
cord-259603-bh198xgl	630	28	of	of	IN
cord-259603-bh198xgl	630	29	the	the	DT
cord-259603-bh198xgl	630	30	nsp10	nsp10	NNPS
cord-259603-bh198xgl	630	31	/	/	SYM
cord-259603-bh198xgl	630	32	nsp14	nsp14	CD
cord-259603-bh198xgl	630	33	complex	complex	NN
cord-259603-bh198xgl	630	34	(	(	-LRB-
cord-259603-bh198xgl	630	35	pdb	pdb	NNP
cord-259603-bh198xgl	630	36	5C8S	5c8s	CD
cord-259603-bh198xgl	630	37	)	)	-RRB-
cord-259603-bh198xgl	630	38	.	.	.
cord-259603-bh198xgl	631	1	The	the	DT
cord-259603-bh198xgl	631	2	nsp10	nsp10	NNPS
cord-259603-bh198xgl	631	3	ribbon	ribbon	NN
cord-259603-bh198xgl	631	4	structure	structure	NN
cord-259603-bh198xgl	631	5	is	be	VBZ
cord-259603-bh198xgl	631	6	shown	show	VBN
cord-259603-bh198xgl	631	7	with	with	IN
cord-259603-bh198xgl	631	8	conserved	conserved	JJ
cord-259603-bh198xgl	631	9	residues	residue	NNS
cord-259603-bh198xgl	631	10	colored	color	VBN
cord-259603-bh198xgl	631	11	in	in	IN
cord-259603-bh198xgl	631	12	blue	blue	JJ
cord-259603-bh198xgl	631	13	(	(	-LRB-
cord-259603-bh198xgl	631	14	using	use	VBG
cord-259603-bh198xgl	631	15	a	a	DT
cord-259603-bh198xgl	631	16	scale	scale	NN
cord-259603-bh198xgl	631	17	from	from	IN
cord-259603-bh198xgl	631	18	dark	dark	JJ
cord-259603-bh198xgl	631	19	to	to	IN
cord-259603-bh198xgl	631	20	light	light	JJ
cord-259603-bh198xgl	631	21	blue	blue	JJ
cord-259603-bh198xgl	631	22	)	)	-RRB-
cord-259603-bh198xgl	631	23	.	.	.
cord-259603-bh198xgl	632	1	The	the	DT
cord-259603-bh198xgl	632	2	coloring	coloring	NN
cord-259603-bh198xgl	632	3	of	of	IN
cord-259603-bh198xgl	632	4	the	the	DT
cord-259603-bh198xgl	632	5	nsp14	nsp14	CD
cord-259603-bh198xgl	632	6	surface	surface	NN
cord-259603-bh198xgl	632	7	is	be	VBZ
cord-259603-bh198xgl	632	8	based	base	VBN
cord-259603-bh198xgl	632	9	on	on	IN
cord-259603-bh198xgl	632	10	the	the	DT
cord-259603-bh198xgl	632	11	conservation	conservation	NN
cord-259603-bh198xgl	632	12	of	of	IN
cord-259603-bh198xgl	632	13	the	the	DT
cord-259603-bh198xgl	632	14	respective	respective	JJ
cord-259603-bh198xgl	632	15	residues	residue	NNS
cord-259603-bh198xgl	632	16	among	among	IN
cord-259603-bh198xgl	632	17	CoVs	CoVs	NNP
cord-259603-bh198xgl	632	18	(	(	-LRB-
cord-259603-bh198xgl	632	19	using	use	VBG
cord-259603-bh198xgl	632	20	a	a	DT
cord-259603-bh198xgl	632	21	scale	scale	NN
cord-259603-bh198xgl	632	22	from	from	IN
cord-259603-bh198xgl	632	23	dark	dark	JJ
cord-259603-bh198xgl	632	24	to	to	IN
cord-259603-bh198xgl	632	25	light	light	JJ
cord-259603-bh198xgl	632	26	red	red	NN
cord-259603-bh198xgl	632	27	)	)	-RRB-
cord-259603-bh198xgl	632	28	.	.	.
cord-259603-bh198xgl	633	1	The	the	DT
cord-259603-bh198xgl	633	2	upper	upper	JJ
cord-259603-bh198xgl	633	3	panel	panel	NN
cord-259603-bh198xgl	633	4	shows	show	VBZ
cord-259603-bh198xgl	633	5	the	the	DT
cord-259603-bh198xgl	633	6	surface	surface	NN
cord-259603-bh198xgl	633	7	containing	contain	VBG
cord-259603-bh198xgl	633	8	the	the	DT
cord-259603-bh198xgl	633	9	ExoN	ExoN	NNP
cord-259603-bh198xgl	633	10	catalytic	catalytic	JJ
cord-259603-bh198xgl	633	11	site	site	NN
cord-259603-bh198xgl	633	12	with	with	IN
cord-259603-bh198xgl	633	13	one	one	CD
cord-259603-bh198xgl	633	14	Mg	Mg	NNP
cord-259603-bh198xgl	633	15	2	2	CD
cord-259603-bh198xgl	633	16	+	+	CC
cord-259603-bh198xgl	633	17	ion	ion	NN
cord-259603-bh198xgl	633	18	bound	bind	VBN
cord-259603-bh198xgl	633	19	in	in	IN
cord-259603-bh198xgl	633	20	the	the	DT
cord-259603-bh198xgl	633	21	active	active	JJ
cord-259603-bh198xgl	633	22	site	site	NN
cord-259603-bh198xgl	633	23	(	(	-LRB-
cord-259603-bh198xgl	633	24	green	green	JJ
cord-259603-bh198xgl	633	25	sphere	sphere	NN
cord-259603-bh198xgl	633	26	)	)	-RRB-
cord-259603-bh198xgl	633	27	.	.	.
cord-259603-bh198xgl	634	1	The	the	DT
cord-259603-bh198xgl	634	2	lower	low	JJR
cord-259603-bh198xgl	634	3	panel	panel	NN
cord-259603-bh198xgl	634	4	shows	show	VBZ
cord-259603-bh198xgl	634	5	the	the	DT
cord-259603-bh198xgl	634	6	opposite	opposite	JJ
cord-259603-bh198xgl	634	7	side	side	NN
cord-259603-bh198xgl	634	8	of	of	IN
cord-259603-bh198xgl	634	9	the	the	DT
cord-259603-bh198xgl	634	10	structure	structure	NN
cord-259603-bh198xgl	634	11	with	with	IN
cord-259603-bh198xgl	634	12	the	the	DT
cord-259603-bh198xgl	634	13	N7-MTase	N7-MTase	NNP
cord-259603-bh198xgl	634	14	active	active	JJ
cord-259603-bh198xgl	634	15	site	site	NN
cord-259603-bh198xgl	634	16	.	.	.
cord-259603-bh198xgl	635	1	The	the	DT
cord-259603-bh198xgl	635	2	cap	cap	NN
cord-259603-bh198xgl	635	3	analog	analog	NN
cord-259603-bh198xgl	635	4	GpppA	GpppA	NNP
cord-259603-bh198xgl	635	5	and	and	CC
cord-259603-bh198xgl	635	6	SAH	SAH	NNP
cord-259603-bh198xgl	635	7	are	be	VBP
cord-259603-bh198xgl	635	8	shown	show	VBN
cord-259603-bh198xgl	635	9	in	in	IN
cord-259603-bh198xgl	635	10	stick	stick	NN
cord-259603-bh198xgl	635	11	representation	representation	NN
cord-259603-bh198xgl	635	12	.	.	.
cord-259603-bh198xgl	636	1	The	the	DT
cord-259603-bh198xgl	636	2	figures	figure	NNS
cord-259603-bh198xgl	636	3	were	be	VBD
cord-259603-bh198xgl	636	4	generated	generate	VBN
cord-259603-bh198xgl	636	5	using	use	VBG
cord-259603-bh198xgl	636	6	UCSF	UCSF	NNP
cord-259603-bh198xgl	636	7	Chimera	Chimera	NNP
cord-259603-bh198xgl	636	8	(	(	-LRB-
cord-259603-bh198xgl	636	9	Pettersen	Pettersen	NNP
cord-259603-bh198xgl	636	10	et	et	NNP
cord-259603-bh198xgl	636	11	al	al	NNP
cord-259603-bh198xgl	636	12	.	.	NNP
cord-259603-bh198xgl	636	13	,	,	,
cord-259603-bh198xgl	636	14	2004	2004	CD
cord-259603-bh198xgl	636	15	)	)	-RRB-
cord-259603-bh198xgl	636	16	.	.	.
cord-259603-bh198xgl	637	1	The	the	DT
cord-259603-bh198xgl	637	2	degree	degree	NN
cord-259603-bh198xgl	637	3	of	of	IN
cord-259603-bh198xgl	637	4	conservation	conservation	NN
cord-259603-bh198xgl	637	5	of	of	IN
cord-259603-bh198xgl	637	6	specific	specific	JJ
cord-259603-bh198xgl	637	7	residues	residue	NNS
cord-259603-bh198xgl	637	8	was	be	VBD
cord-259603-bh198xgl	637	9	determined	determine	VBN
cord-259603-bh198xgl	637	10	using	use	VBG
cord-259603-bh198xgl	637	11	an	an	DT
cord-259603-bh198xgl	637	12	alignment	alignment	NN
cord-259603-bh198xgl	637	13	of	of	IN
cord-259603-bh198xgl	637	14	nsp10	nsp10	NNS
cord-259603-bh198xgl	637	15	and	and	CC
cord-259603-bh198xgl	637	16	nsp14	nsp14	CD
cord-259603-bh198xgl	637	17	sequences	sequence	NNS
cord-259603-bh198xgl	637	18	of	of	IN
cord-259603-bh198xgl	637	19	eight	eight	CD
cord-259603-bh198xgl	637	20	coronaviruses	coronaviruse	NNS
cord-259603-bh198xgl	637	21	representing	represent	VBG
cord-259603-bh198xgl	637	22	the	the	DT
cord-259603-bh198xgl	637	23	four	four	CD
cord-259603-bh198xgl	637	24	genera	genus	NNS
cord-259603-bh198xgl	637	25	of	of	IN
cord-259603-bh198xgl	637	26	the	the	DT
cord-259603-bh198xgl	637	27	Coronavirinae	Coronavirinae	NNP
cord-259603-bh198xgl	637	28	subfamily	subfamily	NN
cord-259603-bh198xgl	637	29	(	(	-LRB-
cord-259603-bh198xgl	637	30	SARS	SARS	NNP
cord-259603-bh198xgl	637	31	-	-	HYPH
cord-259603-bh198xgl	637	32	CoV	CoV	NNP
cord-259603-bh198xgl	637	33	,	,	,
cord-259603-bh198xgl	637	34	MERS	MERS	NNP
cord-259603-bh198xgl	637	35	-	-	HYPH
cord-259603-bh198xgl	637	36	CoV	CoV	NNP
cord-259603-bh198xgl	637	37	,	,	,
cord-259603-bh198xgl	637	38	MHV	MHV	NNP
cord-259603-bh198xgl	637	39	,	,	,
cord-259603-bh198xgl	637	40	TGEV	TGEV	NNP
cord-259603-bh198xgl	637	41	,	,	,
cord-259603-bh198xgl	637	42	FCoV	FCoV	NNP
cord-259603-bh198xgl	637	43	,	,	,
cord-259603-bh198xgl	637	44	HCoV-229E	HCoV-229E	NNP
cord-259603-bh198xgl	637	45	,	,	,
cord-259603-bh198xgl	637	46	IBV	IBV	NNP
cord-259603-bh198xgl	637	47	,	,	,
cord-259603-bh198xgl	637	48	and	and	CC
cord-259603-bh198xgl	637	49	bulbul	bulbul	NN
cord-259603-bh198xgl	637	50	coronavirus	coronavirus	NN
cord-259603-bh198xgl	637	51	HKU11	HKU11	NNP
cord-259603-bh198xgl	637	52	)	)	-RRB-
cord-259603-bh198xgl	637	53	.	.	.
cord-259603-bh198xgl	638	1	nsp14	nsp14	XX
cord-259603-bh198xgl	639	1	X	x	NN
cord-259603-bh198xgl	639	2	-	-	NN
cord-259603-bh198xgl	639	3	ray	ray	JJ
cord-259603-bh198xgl	639	4	structure	structure	NN
cord-259603-bh198xgl	639	5	revealed	reveal	VBD
cord-259603-bh198xgl	639	6	functionally	functionally	RB
cord-259603-bh198xgl	639	7	relevant	relevant	JJ
cord-259603-bh198xgl	639	8	interactions	interaction	NNS
cord-259603-bh198xgl	639	9	between	between	IN
cord-259603-bh198xgl	639	10	the	the	DT
cord-259603-bh198xgl	639	11	N	n	CD
cord-259603-bh198xgl	639	12	-	-	HYPH
cord-259603-bh198xgl	639	13	terminal	terminal	NN
cord-259603-bh198xgl	639	14	(	(	-LRB-
cord-259603-bh198xgl	639	15	ExoN	ExoN	NNP
cord-259603-bh198xgl	639	16	)	)	-RRB-
cord-259603-bh198xgl	639	17	and	and	CC
cord-259603-bh198xgl	639	18	C	c	NN
cord-259603-bh198xgl	639	19	-	-	HYPH
cord-259603-bh198xgl	639	20	terminal	terminal	NN
cord-259603-bh198xgl	639	21	(	(	-LRB-
cord-259603-bh198xgl	639	22	N7-MTase	N7-MTase	NNP
cord-259603-bh198xgl	639	23	)	)	-RRB-
cord-259603-bh198xgl	639	24	domains	domain	NNS
cord-259603-bh198xgl	639	25	,	,	,
cord-259603-bh198xgl	639	26	with	with	IN
cord-259603-bh198xgl	639	27	three	three	CD
cord-259603-bh198xgl	639	28	α	α	NNS
cord-259603-bh198xgl	639	29	-	-	HYPH
cord-259603-bh198xgl	639	30	helices	helix	NNS
cord-259603-bh198xgl	639	31	of	of	IN
cord-259603-bh198xgl	639	32	ExoN	ExoN	NNP
cord-259603-bh198xgl	639	33	stabilizing	stabilize	VBG
cord-259603-bh198xgl	639	34	the	the	DT
cord-259603-bh198xgl	639	35	base	base	NN
cord-259603-bh198xgl	639	36	of	of	IN
cord-259603-bh198xgl	639	37	the	the	DT
cord-259603-bh198xgl	639	38	N7-MTase	N7-MTase	NNP
cord-259603-bh198xgl	639	39	substrate	substrate	NN
cord-259603-bh198xgl	639	40	-	-	HYPH
cord-259603-bh198xgl	639	41	binding	bind	VBG
cord-259603-bh198xgl	639	42	pocket	pocket	NN
cord-259603-bh198xgl	639	43	.	.	.
cord-259603-bh198xgl	640	1	The	the	DT
cord-259603-bh198xgl	640	2	specific	specific	JJ
cord-259603-bh198xgl	640	3	role	role	NN
cord-259603-bh198xgl	640	4	of	of	IN
cord-259603-bh198xgl	640	5	N7-MTase	N7-MTase	NNP
cord-259603-bh198xgl	640	6	activity	activity	NN
cord-259603-bh198xgl	640	7	in	in	IN
cord-259603-bh198xgl	640	8	virus	virus	NN
cord-259603-bh198xgl	640	9	replication	replication	NN
cord-259603-bh198xgl	640	10	was	be	VBD
cord-259603-bh198xgl	640	11	supported	support	VBN
cord-259603-bh198xgl	640	12	by	by	IN
cord-259603-bh198xgl	640	13	reverse	reverse	JJ
cord-259603-bh198xgl	640	14	genetics	genetic	NNS
cord-259603-bh198xgl	640	15	.	.	.
cord-259603-bh198xgl	641	1	Nsp14	Nsp14	NNP
cord-259603-bh198xgl	641	2	mutations	mutation	NNS
cord-259603-bh198xgl	641	3	were	be	VBD
cord-259603-bh198xgl	641	4	introduced	introduce	VBN
cord-259603-bh198xgl	641	5	in	in	IN
cord-259603-bh198xgl	641	6	SARS	SARS	NNP
cord-259603-bh198xgl	641	7	-	-	HYPH
cord-259603-bh198xgl	641	8	CoV	CoV	NNP
cord-259603-bh198xgl	641	9	RNA	RNA	NNP
cord-259603-bh198xgl	641	10	replicons	replicon	NNS
cord-259603-bh198xgl	641	11	expressing	express	VBG
cord-259603-bh198xgl	641	12	a	a	DT
cord-259603-bh198xgl	641	13	luciferase	luciferase	NN
cord-259603-bh198xgl	641	14	reporter	reporter	NN
cord-259603-bh198xgl	641	15	gene	gene	NN
cord-259603-bh198xgl	641	16	.	.	.
cord-259603-bh198xgl	642	1	A	a	DT
cord-259603-bh198xgl	642	2	D331A	D331A	NNP
cord-259603-bh198xgl	642	3	mutation	mutation	NN
cord-259603-bh198xgl	642	4	in	in	IN
cord-259603-bh198xgl	642	5	the	the	DT
cord-259603-bh198xgl	642	6	AdoMet	AdoMet	NNP
cord-259603-bh198xgl	642	7	-	-	HYPH
cord-259603-bh198xgl	642	8	binding	bind	VBG
cord-259603-bh198xgl	642	9	site	site	NN
cord-259603-bh198xgl	642	10	,	,	,
cord-259603-bh198xgl	642	11	which	which	WDT
cord-259603-bh198xgl	642	12	blocks	block	VBZ
cord-259603-bh198xgl	642	13	the	the	DT
cord-259603-bh198xgl	642	14	N7-MTase	n7-mtase	NN
cord-259603-bh198xgl	642	15	activity	activity	NN
cord-259603-bh198xgl	642	16	of	of	IN
cord-259603-bh198xgl	642	17	nsp14	nsp14	NN
cord-259603-bh198xgl	642	18	,	,	,
cord-259603-bh198xgl	642	19	was	be	VBD
cord-259603-bh198xgl	642	20	shown	show	VBN
cord-259603-bh198xgl	642	21	to	to	TO
cord-259603-bh198xgl	642	22	reduce	reduce	VB
cord-259603-bh198xgl	642	23	the	the	DT
cord-259603-bh198xgl	642	24	luciferase	luciferase	JJ
cord-259603-bh198xgl	642	25	expression	expression	NN
cord-259603-bh198xgl	642	26	(	(	-LRB-
cord-259603-bh198xgl	642	27	by	by	IN
cord-259603-bh198xgl	642	28	90	90	CD
cord-259603-bh198xgl	642	29	%	%	NN
cord-259603-bh198xgl	642	30	)	)	-RRB-
cord-259603-bh198xgl	642	31	,	,	,
cord-259603-bh198xgl	642	32	indicating	indicate	VBG
cord-259603-bh198xgl	642	33	that	that	IN
cord-259603-bh198xgl	642	34	viral	viral	JJ
cord-259603-bh198xgl	642	35	RNA	RNA	NNP
cord-259603-bh198xgl	642	36	replication	replication	NN
cord-259603-bh198xgl	642	37	and/or	and/or	CC
cord-259603-bh198xgl	642	38	transcription	transcription	NN
cord-259603-bh198xgl	642	39	were	be	VBD
cord-259603-bh198xgl	642	40	impaired	impair	VBN
cord-259603-bh198xgl	642	41	in	in	IN
cord-259603-bh198xgl	642	42	this	this	DT
cord-259603-bh198xgl	642	43	in	in	FW
cord-259603-bh198xgl	642	44	vitro	vitro	FW
cord-259603-bh198xgl	642	45	system	system	NN
cord-259603-bh198xgl	643	1	(	(	-LRB-
cord-259603-bh198xgl	643	2	Chen	Chen	NNP
cord-259603-bh198xgl	643	3	et	et	NNP
cord-259603-bh198xgl	643	4	al	al	NNP
cord-259603-bh198xgl	643	5	.	.	NNP
cord-259603-bh198xgl	643	6	,	,	,
cord-259603-bh198xgl	643	7	2009c	2009c	CD
cord-259603-bh198xgl	643	8	)	)	-RRB-
cord-259603-bh198xgl	643	9	.	.	.
cord-259603-bh198xgl	644	1	The	the	DT
cord-259603-bh198xgl	644	2	nsp14	nsp14	NN
cord-259603-bh198xgl	644	3	N7-MTase	n7-mtase	NN
cord-259603-bh198xgl	644	4	is	be	VBZ
cord-259603-bh198xgl	644	5	an	an	DT
cord-259603-bh198xgl	644	6	attractive	attractive	JJ
cord-259603-bh198xgl	644	7	target	target	NN
cord-259603-bh198xgl	644	8	for	for	IN
cord-259603-bh198xgl	644	9	antiviral	antiviral	JJ
cord-259603-bh198xgl	644	10	strategies	strategy	NNS
cord-259603-bh198xgl	644	11	,	,	,
cord-259603-bh198xgl	644	12	especially	especially	RB
cord-259603-bh198xgl	644	13	because	because	IN
cord-259603-bh198xgl	644	14	it	-PRON-	PRP
cord-259603-bh198xgl	644	15	exhibits	exhibit	VBZ
cord-259603-bh198xgl	644	16	a	a	DT
cord-259603-bh198xgl	644	17	range	range	NN
cord-259603-bh198xgl	644	18	of	of	IN
cord-259603-bh198xgl	644	19	features	feature	NNS
cord-259603-bh198xgl	644	20	that	that	WDT
cord-259603-bh198xgl	644	21	are	be	VBP
cord-259603-bh198xgl	644	22	distinct	distinct	JJ
cord-259603-bh198xgl	644	23	from	from	IN
cord-259603-bh198xgl	644	24	host	host	NN
cord-259603-bh198xgl	644	25	cell	cell	NN
cord-259603-bh198xgl	644	26	MTases	mtase	NNS
cord-259603-bh198xgl	644	27	.	.	.
cord-259603-bh198xgl	645	1	The	the	DT
cord-259603-bh198xgl	645	2	druggability	druggability	NN
cord-259603-bh198xgl	645	3	of	of	IN
cord-259603-bh198xgl	645	4	the	the	DT
cord-259603-bh198xgl	645	5	enzyme	enzyme	NN
cord-259603-bh198xgl	645	6	was	be	VBD
cord-259603-bh198xgl	645	7	explored	explore	VBN
cord-259603-bh198xgl	645	8	using	use	VBG
cord-259603-bh198xgl	645	9	a	a	DT
cord-259603-bh198xgl	645	10	small	small	JJ
cord-259603-bh198xgl	645	11	set	set	NN
cord-259603-bh198xgl	645	12	of	of	IN
cord-259603-bh198xgl	645	13	previously	previously	RB
cord-259603-bh198xgl	645	14	documented	document	VBN
cord-259603-bh198xgl	645	15	MTase	MTase	NNP
cord-259603-bh198xgl	645	16	inhibitors	inhibitor	NNS
cord-259603-bh198xgl	645	17	.	.	.
cord-259603-bh198xgl	646	1	These	these	DT
cord-259603-bh198xgl	646	2	in	in	IN
cord-259603-bh198xgl	646	3	vitro	vitro	FW
cord-259603-bh198xgl	646	4	assays	assay	NNS
cord-259603-bh198xgl	646	5	revealed	reveal	VBD
cord-259603-bh198xgl	646	6	that	that	IN
cord-259603-bh198xgl	646	7	AdoHcy	AdoHcy	NNP
cord-259603-bh198xgl	646	8	(	(	-LRB-
cord-259603-bh198xgl	646	9	the	the	DT
cord-259603-bh198xgl	646	10	coproduct	coproduct	NN
cord-259603-bh198xgl	646	11	of	of	IN
cord-259603-bh198xgl	646	12	the	the	DT
cord-259603-bh198xgl	646	13	methylation	methylation	NN
cord-259603-bh198xgl	646	14	reaction	reaction	NN
cord-259603-bh198xgl	646	15	)	)	-RRB-
cord-259603-bh198xgl	646	16	,	,	,
cord-259603-bh198xgl	646	17	sinefungin	sinefungin	NNP
cord-259603-bh198xgl	646	18	(	(	-LRB-
cord-259603-bh198xgl	646	19	another	another	DT
cord-259603-bh198xgl	646	20	AdoMet	AdoMet	NNP
cord-259603-bh198xgl	646	21	analog	analog	NN
cord-259603-bh198xgl	646	22	)	)	-RRB-
cord-259603-bh198xgl	646	23	,	,	,
cord-259603-bh198xgl	646	24	and	and	CC
cord-259603-bh198xgl	646	25	ATA	ATA	NNP
cord-259603-bh198xgl	646	26	efficiently	efficiently	RB
cord-259603-bh198xgl	646	27	inhibited	inhibit	VBD
cord-259603-bh198xgl	646	28	nsp14	nsp14	CC
cord-259603-bh198xgl	646	29	N7-MTase	n7-mtase	NN
cord-259603-bh198xgl	646	30	activity	activity	NN
cord-259603-bh198xgl	646	31	with	with	IN
cord-259603-bh198xgl	646	32	IC	IC	NNP
cord-259603-bh198xgl	646	33	50	50	CD
cord-259603-bh198xgl	646	34	values	value	NNS
cord-259603-bh198xgl	646	35	of	of	IN
cord-259603-bh198xgl	646	36	12	12	CD
cord-259603-bh198xgl	646	37	μM	μm	NN
cord-259603-bh198xgl	646	38	,	,	,
cord-259603-bh198xgl	646	39	39.5	39.5	CD
cord-259603-bh198xgl	646	40	nM	nm	NN
cord-259603-bh198xgl	646	41	,	,	,
cord-259603-bh198xgl	646	42	and	and	CC
cord-259603-bh198xgl	646	43	2.1	2.1	CD
cord-259603-bh198xgl	646	44	μM	μm	CD
cord-259603-bh198xgl	646	45	,	,	,
cord-259603-bh198xgl	646	46	respectively	respectively	RB
cord-259603-bh198xgl	646	47	(	(	-LRB-
cord-259603-bh198xgl	646	48	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	646	49	et	et	NNP
cord-259603-bh198xgl	646	50	al	al	NNP
cord-259603-bh198xgl	646	51	.	.	NNP
cord-259603-bh198xgl	646	52	,	,	,
cord-259603-bh198xgl	646	53	2010	2010	CD
cord-259603-bh198xgl	646	54	)	)	-RRB-
cord-259603-bh198xgl	646	55	.	.	.
cord-259603-bh198xgl	647	1	ATA	ATA	NNP
cord-259603-bh198xgl	647	2	was	be	VBD
cord-259603-bh198xgl	647	3	also	also	RB
cord-259603-bh198xgl	647	4	shown	show	VBN
cord-259603-bh198xgl	647	5	to	to	TO
cord-259603-bh198xgl	647	6	limit	limit	VB
cord-259603-bh198xgl	647	7	SARS	SARS	NNP
cord-259603-bh198xgl	647	8	-	-	HYPH
cord-259603-bh198xgl	647	9	CoV	cov	NN
cord-259603-bh198xgl	647	10	replication	replication	NN
cord-259603-bh198xgl	647	11	in	in	IN
cord-259603-bh198xgl	647	12	infected	infected	JJ
cord-259603-bh198xgl	647	13	cells	cell	NNS
cord-259603-bh198xgl	647	14	(	(	-LRB-
cord-259603-bh198xgl	648	1	He	-PRON-	PRP
cord-259603-bh198xgl	648	2	et	et	FW
cord-259603-bh198xgl	648	3	al	al	NNP
cord-259603-bh198xgl	648	4	.	.	NNP
cord-259603-bh198xgl	648	5	,	,	,
cord-259603-bh198xgl	648	6	2004	2004	CD
cord-259603-bh198xgl	648	7	)	)	-RRB-
cord-259603-bh198xgl	648	8	.	.	.
cord-259603-bh198xgl	649	1	In	in	IN
cord-259603-bh198xgl	649	2	the	the	DT
cord-259603-bh198xgl	649	3	yeast-	yeast-	NN
cord-259603-bh198xgl	649	4	△	△	NNP
cord-259603-bh198xgl	649	5	MTase	MTase	NNP
cord-259603-bh198xgl	649	6	trans	trans	NN
cord-259603-bh198xgl	649	7	-	-	NN
cord-259603-bh198xgl	649	8	complementation	complementation	NN
cord-259603-bh198xgl	649	9	assay	assay	NN
cord-259603-bh198xgl	649	10	mentioned	mention	VBN
cord-259603-bh198xgl	649	11	earlier	early	RBR
cord-259603-bh198xgl	649	12	,	,	,
cord-259603-bh198xgl	649	13	micromolar	micromolar	JJ
cord-259603-bh198xgl	649	14	concentrations	concentration	NNS
cord-259603-bh198xgl	649	15	of	of	IN
cord-259603-bh198xgl	649	16	sinefungin	sinefungin	NNP
cord-259603-bh198xgl	649	17	were	be	VBD
cord-259603-bh198xgl	649	18	reported	report	VBN
cord-259603-bh198xgl	649	19	to	to	TO
cord-259603-bh198xgl	649	20	effectively	effectively	RB
cord-259603-bh198xgl	649	21	suppress	suppress	VB
cord-259603-bh198xgl	649	22	the	the	DT
cord-259603-bh198xgl	649	23	nsp14	nsp14	NN
cord-259603-bh198xgl	649	24	N7-MTase	n7-mtase	NN
cord-259603-bh198xgl	649	25	activity	activity	NN
cord-259603-bh198xgl	649	26	of	of	IN
cord-259603-bh198xgl	649	27	SARS	SARS	NNP
cord-259603-bh198xgl	649	28	-	-	HYPH
cord-259603-bh198xgl	649	29	CoV	CoV	NNP
cord-259603-bh198xgl	649	30	,	,	,
cord-259603-bh198xgl	649	31	MHV	MHV	NNP
cord-259603-bh198xgl	649	32	,	,	,
cord-259603-bh198xgl	649	33	transmissible	transmissible	JJ
cord-259603-bh198xgl	649	34	gastroenteritis	gastroenteritis	NN
cord-259603-bh198xgl	649	35	virus	virus	NN
cord-259603-bh198xgl	649	36	(	(	-LRB-
cord-259603-bh198xgl	649	37	TGEV	TGEV	NNP
cord-259603-bh198xgl	649	38	)	)	-RRB-
cord-259603-bh198xgl	649	39	,	,	,
cord-259603-bh198xgl	649	40	and	and	CC
cord-259603-bh198xgl	649	41	IBV	IBV	NNP
cord-259603-bh198xgl	649	42	(	(	-LRB-
cord-259603-bh198xgl	649	43	Sun	Sun	NNP
cord-259603-bh198xgl	649	44	et	et	FW
cord-259603-bh198xgl	649	45	al	al	NNP
cord-259603-bh198xgl	649	46	.	.	NNP
cord-259603-bh198xgl	649	47	,	,	,
cord-259603-bh198xgl	649	48	2014	2014	CD
cord-259603-bh198xgl	649	49	)	)	-RRB-
cord-259603-bh198xgl	649	50	.	.	.
cord-259603-bh198xgl	650	1	However	however	RB
cord-259603-bh198xgl	650	2	,	,	,
cord-259603-bh198xgl	650	3	other	other	JJ
cord-259603-bh198xgl	650	4	compounds	compound	NNS
cord-259603-bh198xgl	650	5	,	,	,
cord-259603-bh198xgl	650	6	such	such	JJ
cord-259603-bh198xgl	650	7	as	as	IN
cord-259603-bh198xgl	650	8	ATA	ATA	NNP
cord-259603-bh198xgl	650	9	and	and	CC
cord-259603-bh198xgl	650	10	AdoHcy	AdoHcy	NNP
cord-259603-bh198xgl	650	11	,	,	,
cord-259603-bh198xgl	650	12	did	do	VBD
cord-259603-bh198xgl	650	13	not	not	RB
cord-259603-bh198xgl	650	14	exert	exert	VB
cord-259603-bh198xgl	650	15	an	an	DT
cord-259603-bh198xgl	650	16	inhibitory	inhibitory	JJ
cord-259603-bh198xgl	650	17	effect	effect	NN
cord-259603-bh198xgl	650	18	in	in	IN
cord-259603-bh198xgl	650	19	the	the	DT
cord-259603-bh198xgl	650	20	context	context	NN
cord-259603-bh198xgl	650	21	of	of	IN
cord-259603-bh198xgl	650	22	yeast	yeast	NN
cord-259603-bh198xgl	650	23	cells	cell	NNS
cord-259603-bh198xgl	650	24	.	.	.
cord-259603-bh198xgl	651	1	These	these	DT
cord-259603-bh198xgl	651	2	discrepancies	discrepancy	NNS
cord-259603-bh198xgl	651	3	may	may	MD
cord-259603-bh198xgl	651	4	reflect	reflect	VB
cord-259603-bh198xgl	651	5	differences	difference	NNS
cord-259603-bh198xgl	651	6	in	in	IN
cord-259603-bh198xgl	651	7	cell	cell	NN
cord-259603-bh198xgl	651	8	penetration	penetration	NN
cord-259603-bh198xgl	651	9	of	of	IN
cord-259603-bh198xgl	651	10	the	the	DT
cord-259603-bh198xgl	651	11	compounds	compound	NNS
cord-259603-bh198xgl	651	12	between	between	IN
cord-259603-bh198xgl	651	13	yeast	yeast	NN
cord-259603-bh198xgl	651	14	and	and	CC
cord-259603-bh198xgl	651	15	(	(	-LRB-
cord-259603-bh198xgl	651	16	virus	virus	NN
cord-259603-bh198xgl	651	17	-	-	HYPH
cord-259603-bh198xgl	651	18	infected	infect	VBN
cord-259603-bh198xgl	651	19	)	)	-RRB-
cord-259603-bh198xgl	651	20	mammalian	mammalian	JJ
cord-259603-bh198xgl	651	21	cells	cell	NNS
cord-259603-bh198xgl	651	22	.	.	.
cord-259603-bh198xgl	652	1	The	the	DT
cord-259603-bh198xgl	652	2	yeast	yeast	NN
cord-259603-bh198xgl	652	3	system	system	NN
cord-259603-bh198xgl	652	4	was	be	VBD
cord-259603-bh198xgl	652	5	also	also	RB
cord-259603-bh198xgl	652	6	applied	apply	VBN
cord-259603-bh198xgl	652	7	to	to	TO
cord-259603-bh198xgl	652	8	screen	screen	VB
cord-259603-bh198xgl	652	9	a	a	DT
cord-259603-bh198xgl	652	10	library	library	NN
cord-259603-bh198xgl	652	11	of	of	IN
cord-259603-bh198xgl	652	12	3000	3000	CD
cord-259603-bh198xgl	652	13	natural	natural	JJ
cord-259603-bh198xgl	652	14	product	product	NN
cord-259603-bh198xgl	652	15	extracts	extract	NNS
cord-259603-bh198xgl	652	16	,	,	,
cord-259603-bh198xgl	652	17	and	and	CC
cord-259603-bh198xgl	652	18	three	three	CD
cord-259603-bh198xgl	652	19	hits	hit	NNS
cord-259603-bh198xgl	652	20	were	be	VBD
cord-259603-bh198xgl	652	21	obtained	obtain	VBN
cord-259603-bh198xgl	652	22	displaying	display	VBG
cord-259603-bh198xgl	652	23	potent	potent	JJ
cord-259603-bh198xgl	652	24	inhibitory	inhibitory	JJ
cord-259603-bh198xgl	652	25	effects	effect	NNS
cord-259603-bh198xgl	652	26	on	on	IN
cord-259603-bh198xgl	652	27	the	the	DT
cord-259603-bh198xgl	652	28	CoV	cov	NN
cord-259603-bh198xgl	652	29	N7-MTase	n7-mtase	NN
cord-259603-bh198xgl	653	1	(	(	-LRB-
cord-259603-bh198xgl	653	2	Sun	Sun	NNP
cord-259603-bh198xgl	653	3	et	et	FW
cord-259603-bh198xgl	653	4	al	al	NNP
cord-259603-bh198xgl	653	5	.	.	.
cord-259603-bh198xgl	654	1	,	,	,
cord-259603-bh198xgl	654	2	2014	2014	CD
cord-259603-bh198xgl	654	3	)	)	-RRB-
cord-259603-bh198xgl	654	4	.	.	.
cord-259603-bh198xgl	655	1	Further	further	JJ
cord-259603-bh198xgl	655	2	work	work	NN
cord-259603-bh198xgl	655	3	is	be	VBZ
cord-259603-bh198xgl	655	4	needed	need	VBN
cord-259603-bh198xgl	655	5	to	to	TO
cord-259603-bh198xgl	655	6	optimize	optimize	VB
cord-259603-bh198xgl	655	7	these	these	DT
cord-259603-bh198xgl	655	8	hits	hit	NNS
cord-259603-bh198xgl	655	9	and	and	CC
cord-259603-bh198xgl	655	10	test	test	VBP
cord-259603-bh198xgl	655	11	their	-PRON-	PRP$
cord-259603-bh198xgl	655	12	inhibitory	inhibitory	JJ
cord-259603-bh198xgl	655	13	activities	activity	NNS
cord-259603-bh198xgl	655	14	in	in	IN
cord-259603-bh198xgl	655	15	assays	assay	NNS
cord-259603-bh198xgl	655	16	using	use	VBG
cord-259603-bh198xgl	655	17	CoV	cov	NN
cord-259603-bh198xgl	655	18	-	-	HYPH
cord-259603-bh198xgl	655	19	infected	infect	VBN
cord-259603-bh198xgl	655	20	cells	cell	NNS
cord-259603-bh198xgl	655	21	.	.	.
cord-259603-bh198xgl	656	1	The	the	DT
cord-259603-bh198xgl	656	2	presence	presence	NN
cord-259603-bh198xgl	656	3	of	of	IN
cord-259603-bh198xgl	656	4	a	a	DT
cord-259603-bh198xgl	656	5	2	2	CD
cord-259603-bh198xgl	656	6	0	0	CD
cord-259603-bh198xgl	656	7	-O	-o	CD
cord-259603-bh198xgl	656	8	-	-	HYPH
cord-259603-bh198xgl	656	9	methyl	methyl	JJ
cord-259603-bh198xgl	656	10	transferase	transferase	NN
cord-259603-bh198xgl	656	11	(	(	-LRB-
cord-259603-bh198xgl	656	12	2	2	CD
cord-259603-bh198xgl	656	13	0	0	CD
cord-259603-bh198xgl	656	14	-O	-o	CD
cord-259603-bh198xgl	656	15	-	-	HYPH
cord-259603-bh198xgl	656	16	MTase	MTase	NNP
cord-259603-bh198xgl	656	17	)	)	-RRB-
cord-259603-bh198xgl	656	18	domain	domain	NN
cord-259603-bh198xgl	656	19	in	in	IN
cord-259603-bh198xgl	656	20	CoV	CoV	NNP
cord-259603-bh198xgl	656	21	nsp16	nsp16	NNS
cord-259603-bh198xgl	656	22	was	be	VBD
cord-259603-bh198xgl	656	23	first	first	RB
cord-259603-bh198xgl	656	24	inferred	infer	VBN
cord-259603-bh198xgl	656	25	using	use	VBG
cord-259603-bh198xgl	656	26	bioinformatics	bioinformatic	NNS
cord-259603-bh198xgl	656	27	(	(	-LRB-
cord-259603-bh198xgl	656	28	Snijder	Snijder	NNP
cord-259603-bh198xgl	656	29	et	et	NNP
cord-259603-bh198xgl	656	30	al	al	NNP
cord-259603-bh198xgl	656	31	.	.	NNP
cord-259603-bh198xgl	656	32	,	,	,
cord-259603-bh198xgl	656	33	2003	2003	CD
cord-259603-bh198xgl	656	34	;	;	:
cord-259603-bh198xgl	656	35	von	von	NNP
cord-259603-bh198xgl	656	36	Grotthuss	Grotthuss	NNP
cord-259603-bh198xgl	656	37	et	et	FW
cord-259603-bh198xgl	656	38	al	al	NNP
cord-259603-bh198xgl	656	39	.	.	NNP
cord-259603-bh198xgl	656	40	,	,	,
cord-259603-bh198xgl	656	41	2003	2003	CD
cord-259603-bh198xgl	656	42	)	)	-RRB-
cord-259603-bh198xgl	656	43	.	.	.
cord-259603-bh198xgl	657	1	Computational	computational	JJ
cord-259603-bh198xgl	657	2	threading	threading	NN
cord-259603-bh198xgl	657	3	produced	produce	VBD
cord-259603-bh198xgl	657	4	a	a	DT
cord-259603-bh198xgl	657	5	model	model	NN
cord-259603-bh198xgl	657	6	containing	contain	VBG
cord-259603-bh198xgl	657	7	a	a	DT
cord-259603-bh198xgl	657	8	conserved	conserve	VBN
cord-259603-bh198xgl	657	9	K	K	NNP
cord-259603-bh198xgl	657	10	-	-	HYPH
cord-259603-bh198xgl	657	11	D	D	NNP
cord-259603-bh198xgl	657	12	-	-	HYPH
cord-259603-bh198xgl	657	13	K	k	NN
cord-259603-bh198xgl	657	14	-	-	HYPH
cord-259603-bh198xgl	657	15	E	e	NN
cord-259603-bh198xgl	657	16	catalytic	catalytic	JJ
cord-259603-bh198xgl	657	17	tetrad	tetrad	NN
cord-259603-bh198xgl	657	18	that	that	WDT
cord-259603-bh198xgl	657	19	is	be	VBZ
cord-259603-bh198xgl	657	20	characteristic	characteristic	JJ
cord-259603-bh198xgl	657	21	of	of	IN
cord-259603-bh198xgl	657	22	AdoMet	AdoMet	NNP
cord-259603-bh198xgl	657	23	-	-	HYPH
cord-259603-bh198xgl	657	24	dependent	dependent	JJ
cord-259603-bh198xgl	657	25	2	2	CD
cord-259603-bh198xgl	657	26	0	0	CD
cord-259603-bh198xgl	657	27	-O	-o	CD
cord-259603-bh198xgl	657	28	-	-	HYPH
cord-259603-bh198xgl	657	29	MTases	mtase	NNS
cord-259603-bh198xgl	657	30	and	and	CC
cord-259603-bh198xgl	657	31	a	a	DT
cord-259603-bh198xgl	657	32	conserved	conserve	VBN
cord-259603-bh198xgl	657	33	AdoMet	AdoMet	NNP
cord-259603-bh198xgl	657	34	-	-	HYPH
cord-259603-bh198xgl	657	35	binding	bind	VBG
cord-259603-bh198xgl	657	36	site	site	NN
cord-259603-bh198xgl	657	37	(	(	-LRB-
cord-259603-bh198xgl	657	38	Fig	Fig	NNP
cord-259603-bh198xgl	657	39	.	.	NNP
cord-259603-bh198xgl	657	40	7	7	CD
cord-259603-bh198xgl	657	41	)	)	-RRB-
cord-259603-bh198xgl	658	1	(	(	-LRB-
cord-259603-bh198xgl	658	2	von	von	NNP
cord-259603-bh198xgl	658	3	Grotthuss	Grotthuss	NNP
cord-259603-bh198xgl	658	4	et	et	FW
cord-259603-bh198xgl	658	5	al	al	NNP
cord-259603-bh198xgl	658	6	.	.	NNP
cord-259603-bh198xgl	658	7	,	,	,
cord-259603-bh198xgl	658	8	2003	2003	CD
cord-259603-bh198xgl	658	9	)	)	-RRB-
cord-259603-bh198xgl	658	10	.	.	.
cord-259603-bh198xgl	659	1	The	the	DT
cord-259603-bh198xgl	659	2	2	2	CD
cord-259603-bh198xgl	659	3	0	0	CD
cord-259603-bh198xgl	659	4	-O	-o	CD
cord-259603-bh198xgl	659	5	-	-	HYPH
cord-259603-bh198xgl	659	6	MTase	mtase	JJ
cord-259603-bh198xgl	659	7	activity	activity	NN
cord-259603-bh198xgl	659	8	was	be	VBD
cord-259603-bh198xgl	659	9	then	then	RB
cord-259603-bh198xgl	659	10	confirmed	confirm	VBN
cord-259603-bh198xgl	659	11	by	by	IN
cord-259603-bh198xgl	659	12	in	in	FW
cord-259603-bh198xgl	659	13	vitro	vitro	FW
cord-259603-bh198xgl	659	14	biochemical	biochemical	JJ
cord-259603-bh198xgl	659	15	assays	assay	NNS
cord-259603-bh198xgl	659	16	using	use	VBG
cord-259603-bh198xgl	659	17	purified	purify	VBN
cord-259603-bh198xgl	659	18	FCoV	FCoV	NNP
cord-259603-bh198xgl	659	19	nsp16	nsp16	NNS
cord-259603-bh198xgl	660	1	(	(	-LRB-
cord-259603-bh198xgl	660	2	Decroly	Decroly	NNP
cord-259603-bh198xgl	660	3	et	et	NNP
cord-259603-bh198xgl	660	4	al	al	NNP
cord-259603-bh198xgl	660	5	.	.	NNP
cord-259603-bh198xgl	660	6	,	,	,
cord-259603-bh198xgl	660	7	2008	2008	CD
cord-259603-bh198xgl	660	8	)	)	-RRB-
cord-259603-bh198xgl	660	9	.	.	.
cord-259603-bh198xgl	661	1	The	the	DT
cord-259603-bh198xgl	661	2	recombinant	recombinant	JJ
cord-259603-bh198xgl	661	3	protein	protein	NN
cord-259603-bh198xgl	661	4	was	be	VBD
cord-259603-bh198xgl	661	5	shown	show	VBN
cord-259603-bh198xgl	661	6	to	to	TO
cord-259603-bh198xgl	661	7	specifically	specifically	RB
cord-259603-bh198xgl	661	8	recognize	recognize	VB
cord-259603-bh198xgl	661	9	short	short	JJ
cord-259603-bh198xgl	661	10	,	,	,
cord-259603-bh198xgl	661	11	cap-0-containing	cap-0-containe	VBG
cord-259603-bh198xgl	661	12	RNAs	rna	NNS
cord-259603-bh198xgl	661	13	and	and	CC
cord-259603-bh198xgl	661	14	to	to	TO
cord-259603-bh198xgl	661	15	transfer	transfer	VB
cord-259603-bh198xgl	661	16	a	a	DT
cord-259603-bh198xgl	661	17	methyl	methyl	NN
cord-259603-bh198xgl	661	18	group	group	NN
cord-259603-bh198xgl	661	19	from	from	IN
cord-259603-bh198xgl	661	20	AdoMet	AdoMet	NNP
cord-259603-bh198xgl	661	21	to	to	IN
cord-259603-bh198xgl	661	22	the	the	DT
cord-259603-bh198xgl	661	23	2	2	CD
cord-259603-bh198xgl	661	24	0	0	CD
cord-259603-bh198xgl	661	25	-O	-o	CD
cord-259603-bh198xgl	661	26	position	position	NN
cord-259603-bh198xgl	661	27	of	of	IN
cord-259603-bh198xgl	661	28	the	the	DT
cord-259603-bh198xgl	661	29	first	first	JJ
cord-259603-bh198xgl	661	30	nucleotide	nucleotide	NN
cord-259603-bh198xgl	661	31	of	of	IN
cord-259603-bh198xgl	661	32	the	the	DT
cord-259603-bh198xgl	661	33	N7-methylated	n7-methylate	VBN
cord-259603-bh198xgl	661	34	substrate	substrate	NN
cord-259603-bh198xgl	661	35	.	.	.
cord-259603-bh198xgl	662	1	In	in	IN
cord-259603-bh198xgl	662	2	contrast	contrast	NN
cord-259603-bh198xgl	662	3	,	,	,
cord-259603-bh198xgl	662	4	a	a	DT
cord-259603-bh198xgl	662	5	recombinant	recombinant	JJ
cord-259603-bh198xgl	662	6	form	form	NN
cord-259603-bh198xgl	662	7	of	of	IN
cord-259603-bh198xgl	662	8	the	the	DT
cord-259603-bh198xgl	662	9	SARS	SARS	NNP
cord-259603-bh198xgl	662	10	-	-	HYPH
cord-259603-bh198xgl	662	11	CoV	CoV	NNP
cord-259603-bh198xgl	662	12	nsp16	nsp16	NNS
cord-259603-bh198xgl	662	13	homolog	homolog	NN
cord-259603-bh198xgl	662	14	was	be	VBD
cord-259603-bh198xgl	662	15	inactive	inactive	JJ
cord-259603-bh198xgl	662	16	under	under	IN
cord-259603-bh198xgl	662	17	similar	similar	JJ
cord-259603-bh198xgl	662	18	experimental	experimental	JJ
cord-259603-bh198xgl	662	19	conditions	condition	NNS
cord-259603-bh198xgl	662	20	.	.	.
cord-259603-bh198xgl	663	1	Since	since	IN
cord-259603-bh198xgl	663	2	yeast	yeast	NN
cord-259603-bh198xgl	663	3	two	two	CD
cord-259603-bh198xgl	663	4	-	-	HYPH
cord-259603-bh198xgl	663	5	hybrid	hybrid	NN
cord-259603-bh198xgl	663	6	experiments	experiment	NNS
cord-259603-bh198xgl	663	7	and	and	CC
cord-259603-bh198xgl	663	8	GST	GST	NNP
cord-259603-bh198xgl	663	9	pull	pull	VB
cord-259603-bh198xgl	663	10	-	-	HYPH
cord-259603-bh198xgl	663	11	down	down	RP
cord-259603-bh198xgl	663	12	assays	assay	NNS
cord-259603-bh198xgl	663	13	had	have	VBD
cord-259603-bh198xgl	663	14	revealed	reveal	VBN
cord-259603-bh198xgl	663	15	that	that	IN
cord-259603-bh198xgl	663	16	SARS	SARS	NNP
cord-259603-bh198xgl	663	17	-	-	HYPH
cord-259603-bh198xgl	663	18	CoV	CoV	NNP
cord-259603-bh198xgl	663	19	nsp16	nsp16	NNS
cord-259603-bh198xgl	663	20	strongly	strongly	RB
cord-259603-bh198xgl	663	21	interacts	interact	VBZ
cord-259603-bh198xgl	663	22	with	with	IN
cord-259603-bh198xgl	663	23	nsp10	nsp10	HYPH
cord-259603-bh198xgl	663	24	Pan	Pan	NNP
cord-259603-bh198xgl	663	25	et	et	NNP
cord-259603-bh198xgl	663	26	al	al	NNP
cord-259603-bh198xgl	663	27	.	.	NNP
cord-259603-bh198xgl	663	28	,	,	,
cord-259603-bh198xgl	663	29	2008	2008	CD
cord-259603-bh198xgl	663	30	)	)	-RRB-
cord-259603-bh198xgl	663	31	,	,	,
cord-259603-bh198xgl	663	32	a	a	DT
cord-259603-bh198xgl	663	33	possible	possible	JJ
cord-259603-bh198xgl	663	34	involvement	involvement	NN
cord-259603-bh198xgl	663	35	of	of	IN
cord-259603-bh198xgl	663	36	the	the	DT
cord-259603-bh198xgl	663	37	latter	latter	JJ
cord-259603-bh198xgl	663	38	in	in	IN
cord-259603-bh198xgl	663	39	regulating	regulate	VBG
cord-259603-bh198xgl	663	40	or	or	CC
cord-259603-bh198xgl	663	41	supporting	support	VBG
cord-259603-bh198xgl	663	42	the	the	DT
cord-259603-bh198xgl	663	43	2	2	CD
cord-259603-bh198xgl	663	44	0	0	CD
cord-259603-bh198xgl	663	45	-O	-o	CD
cord-259603-bh198xgl	663	46	-	-	HYPH
cord-259603-bh198xgl	663	47	MTase	mtase	JJ
cord-259603-bh198xgl	663	48	activity	activity	NN
cord-259603-bh198xgl	663	49	was	be	VBD
cord-259603-bh198xgl	663	50	tested	test	VBN
cord-259603-bh198xgl	663	51	.	.	.
cord-259603-bh198xgl	664	1	It	-PRON-	PRP
cord-259603-bh198xgl	664	2	was	be	VBD
cord-259603-bh198xgl	664	3	shown	show	VBN
cord-259603-bh198xgl	664	4	that	that	IN
cord-259603-bh198xgl	664	5	purified	purify	VBN
cord-259603-bh198xgl	664	6	nsp10	nsp10	NNP
cord-259603-bh198xgl	664	7	interacts	interact	VBZ
cord-259603-bh198xgl	664	8	with	with	IN
cord-259603-bh198xgl	664	9	nsp16	nsp16	NNS
cord-259603-bh198xgl	664	10	in	in	IN
cord-259603-bh198xgl	664	11	vitro	vitro	FW
cord-259603-bh198xgl	664	12	and	and	CC
cord-259603-bh198xgl	664	13	thereby	thereby	RB
cord-259603-bh198xgl	664	14	triggers	trigger	VBZ
cord-259603-bh198xgl	664	15	a	a	DT
cord-259603-bh198xgl	664	16	robust	robust	JJ
cord-259603-bh198xgl	664	17	2	2	CD
cord-259603-bh198xgl	664	18	0	0	CD
cord-259603-bh198xgl	664	19	-O	-o	CD
cord-259603-bh198xgl	664	20	-	-	HYPH
cord-259603-bh198xgl	664	21	MTase	mtase	JJ
cord-259603-bh198xgl	664	22	activity	activity	NN
cord-259603-bh198xgl	664	23	(	(	-LRB-
cord-259603-bh198xgl	664	24	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	664	25	et	et	NNP
cord-259603-bh198xgl	664	26	al	al	NNP
cord-259603-bh198xgl	664	27	.	.	NNP
cord-259603-bh198xgl	664	28	,	,	,
cord-259603-bh198xgl	664	29	2010	2010	CD
cord-259603-bh198xgl	664	30	)	)	-RRB-
cord-259603-bh198xgl	664	31	.	.	.
cord-259603-bh198xgl	665	1	Effective	effective	JJ
cord-259603-bh198xgl	665	2	methyl	methyl	NN
cord-259603-bh198xgl	665	3	transfer	transfer	NN
cord-259603-bh198xgl	665	4	was	be	VBD
cord-259603-bh198xgl	665	5	demonstrated	demonstrate	VBN
cord-259603-bh198xgl	665	6	using	use	VBG
cord-259603-bh198xgl	665	7	synthetic	synthetic	JJ
cord-259603-bh198xgl	665	8	capped	cap	VBN
cord-259603-bh198xgl	665	9	N7-methylated	N7-methylated	NNP
cord-259603-bh198xgl	665	10	RNA	RNA	NNP
cord-259603-bh198xgl	665	11	and	and	CC
cord-259603-bh198xgl	665	12	longer	long	RBR
cord-259603-bh198xgl	665	13	RNA	RNA	NNP
cord-259603-bh198xgl	665	14	mimicking	mimic	VBG
cord-259603-bh198xgl	665	15	the	the	DT
cord-259603-bh198xgl	665	16	5	5	CD
cord-259603-bh198xgl	665	17	0	0	CD
cord-259603-bh198xgl	665	18	end	end	NN
cord-259603-bh198xgl	665	19	of	of	IN
cord-259603-bh198xgl	665	20	the	the	DT
cord-259603-bh198xgl	665	21	SARS	SARS	NNP
cord-259603-bh198xgl	665	22	-	-	HYPH
cord-259603-bh198xgl	665	23	CoV	CoV	NNP
cord-259603-bh198xgl	665	24	genome	genome	NN
cord-259603-bh198xgl	665	25	(	(	-LRB-
cord-259603-bh198xgl	665	26	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	665	27	et	et	NNP
cord-259603-bh198xgl	665	28	al	al	NNP
cord-259603-bh198xgl	665	29	.	.	NNP
cord-259603-bh198xgl	665	30	,	,	,
cord-259603-bh198xgl	665	31	2010	2010	CD
cord-259603-bh198xgl	665	32	)	)	-RRB-
cord-259603-bh198xgl	665	33	.	.	.
cord-259603-bh198xgl	666	1	In	in	IN
cord-259603-bh198xgl	666	2	contrast	contrast	NN
cord-259603-bh198xgl	666	3	,	,	,
cord-259603-bh198xgl	666	4	RNA	RNA	NNP
cord-259603-bh198xgl	666	5	with	with	IN
cord-259603-bh198xgl	666	6	a	a	DT
cord-259603-bh198xgl	666	7	nonmethylated	nonmethylated	JJ
cord-259603-bh198xgl	666	8	cap	cap	NN
cord-259603-bh198xgl	666	9	structure	structure	NN
cord-259603-bh198xgl	667	1	(	(	-LRB-
cord-259603-bh198xgl	667	2	Gppp	Gppp	NNP
cord-259603-bh198xgl	667	3	-	-	HYPH
cord-259603-bh198xgl	667	4	RNA	RNA	NNP
cord-259603-bh198xgl	667	5	)	)	-RRB-
cord-259603-bh198xgl	667	6	was	be	VBD
cord-259603-bh198xgl	667	7	not	not	RB
cord-259603-bh198xgl	667	8	bound	bind	VBN
cord-259603-bh198xgl	667	9	by	by	IN
cord-259603-bh198xgl	667	10	the	the	DT
cord-259603-bh198xgl	667	11	nsp10/	nsp10/	NNS
cord-259603-bh198xgl	668	1	nsp16	nsp16	NNS
cord-259603-bh198xgl	668	2	complex	complex	JJ
cord-259603-bh198xgl	668	3	and	and	CC
cord-259603-bh198xgl	668	4	,	,	,
cord-259603-bh198xgl	668	5	consequently	consequently	RB
cord-259603-bh198xgl	668	6	,	,	,
cord-259603-bh198xgl	668	7	could	could	MD
cord-259603-bh198xgl	668	8	not	not	RB
cord-259603-bh198xgl	668	9	serve	serve	VB
cord-259603-bh198xgl	668	10	as	as	IN
cord-259603-bh198xgl	668	11	a	a	DT
cord-259603-bh198xgl	668	12	substrate	substrate	NN
cord-259603-bh198xgl	668	13	.	.	.
cord-259603-bh198xgl	669	1	These	these	DT
cord-259603-bh198xgl	669	2	observations	observation	NNS
cord-259603-bh198xgl	669	3	suggest	suggest	VBP
cord-259603-bh198xgl	669	4	that	that	IN
cord-259603-bh198xgl	669	5	SARS	SARS	NNP
cord-259603-bh198xgl	669	6	-	-	HYPH
cord-259603-bh198xgl	669	7	CoV	CoV	NNP
cord-259603-bh198xgl	669	8	mRNA	mrna	NN
cord-259603-bh198xgl	669	9	capping	capping	NN
cord-259603-bh198xgl	669	10	follows	follow	VBZ
cord-259603-bh198xgl	669	11	a	a	DT
cord-259603-bh198xgl	669	12	strict	strict	JJ
cord-259603-bh198xgl	669	13	order	order	NN
cord-259603-bh198xgl	669	14	of	of	IN
cord-259603-bh198xgl	669	15	reaction	reaction	NN
cord-259603-bh198xgl	669	16	steps	step	NNS
cord-259603-bh198xgl	669	17	:	:	:
cord-259603-bh198xgl	669	18	after	after	IN
cord-259603-bh198xgl	669	19	GTP	GTP	NNP
cord-259603-bh198xgl	669	20	transfer	transfer	NN
cord-259603-bh198xgl	669	21	by	by	IN
cord-259603-bh198xgl	669	22	the	the	DT
cord-259603-bh198xgl	669	23	still	still	RB
cord-259603-bh198xgl	669	24	elusive	elusive	JJ
cord-259603-bh198xgl	669	25	GTase	GTase	NNP
cord-259603-bh198xgl	669	26	,	,	,
cord-259603-bh198xgl	669	27	the	the	DT
cord-259603-bh198xgl	669	28	cap	cap	NN
cord-259603-bh198xgl	669	29	is	be	VBZ
cord-259603-bh198xgl	669	30	methylated	methylate	VBN
cord-259603-bh198xgl	669	31	by	by	IN
cord-259603-bh198xgl	669	32	the	the	DT
cord-259603-bh198xgl	669	33	nsp14	nsp14	CD
cord-259603-bh198xgl	669	34	N7-MTase	n7-mtase	NN
cord-259603-bh198xgl	669	35	at	at	IN
cord-259603-bh198xgl	669	36	the	the	DT
cord-259603-bh198xgl	669	37	guanosine	guanosine	NN
cord-259603-bh198xgl	669	38	-	-	HYPH
cord-259603-bh198xgl	669	39	N7	n7	NN
cord-259603-bh198xgl	669	40	position	position	NN
cord-259603-bh198xgl	669	41	to	to	TO
cord-259603-bh198xgl	669	42	produce	produce	VB
cord-259603-bh198xgl	669	43	a	a	DT
cord-259603-bh198xgl	669	44	cap-0	cap-0	NN
cord-259603-bh198xgl	669	45	structure	structure	NN
cord-259603-bh198xgl	669	46	that	that	IN
cord-259603-bh198xgl	669	47	,	,	,
cord-259603-bh198xgl	669	48	in	in	IN
cord-259603-bh198xgl	669	49	a	a	DT
cord-259603-bh198xgl	669	50	subsequent	subsequent	JJ
cord-259603-bh198xgl	669	51	reaction	reaction	NN
cord-259603-bh198xgl	669	52	,	,	,
cord-259603-bh198xgl	669	53	is	be	VBZ
cord-259603-bh198xgl	669	54	bound	bind	VBN
cord-259603-bh198xgl	669	55	by	by	IN
cord-259603-bh198xgl	669	56	the	the	DT
cord-259603-bh198xgl	669	57	nsp10/	nsp10/	NNS
cord-259603-bh198xgl	670	1	nsp16	nsp16	NNS
cord-259603-bh198xgl	670	2	complex	complex	JJ
cord-259603-bh198xgl	670	3	and	and	CC
cord-259603-bh198xgl	670	4	converted	convert	VBD
cord-259603-bh198xgl	670	5	to	to	IN
cord-259603-bh198xgl	670	6	a	a	DT
cord-259603-bh198xgl	670	7	cap-1	cap-1	NNP
cord-259603-bh198xgl	670	8	structure	structure	NN
cord-259603-bh198xgl	670	9	employing	employ	VBG
cord-259603-bh198xgl	670	10	the	the	DT
cord-259603-bh198xgl	670	11	2	2	CD
cord-259603-bh198xgl	670	12	0	0	CD
cord-259603-bh198xgl	670	13	-O	-o	CD
cord-259603-bh198xgl	670	14	-	-	HYPH
cord-259603-bh198xgl	670	15	MTase	mtase	JJ
cord-259603-bh198xgl	670	16	activity	activity	NN
cord-259603-bh198xgl	670	17	of	of	IN
cord-259603-bh198xgl	670	18	nsp16	nsp16	NNS
cord-259603-bh198xgl	670	19	.	.	.
cord-259603-bh198xgl	671	1	Mutagenesis	Mutagenesis	NNP
cord-259603-bh198xgl	671	2	of	of	IN
cord-259603-bh198xgl	671	3	SARS	SARS	NNP
cord-259603-bh198xgl	671	4	-	-	HYPH
cord-259603-bh198xgl	671	5	CoV	CoV	NNP
cord-259603-bh198xgl	671	6	nsp10	nsp10	NNPS
cord-259603-bh198xgl	671	7	and	and	CC
cord-259603-bh198xgl	671	8	nsp16	nsp16	NNS
cord-259603-bh198xgl	671	9	confirmed	confirm	VBD
cord-259603-bh198xgl	671	10	the	the	DT
cord-259603-bh198xgl	671	11	importance	importance	NN
cord-259603-bh198xgl	671	12	of	of	IN
cord-259603-bh198xgl	671	13	the	the	DT
cord-259603-bh198xgl	671	14	catalytic	catalytic	JJ
cord-259603-bh198xgl	671	15	tetrad	tetrad	NN
cord-259603-bh198xgl	671	16	of	of	IN
cord-259603-bh198xgl	671	17	the	the	DT
cord-259603-bh198xgl	671	18	nsp16	nsp16	NNS
cord-259603-bh198xgl	671	19	2	2	CD
cord-259603-bh198xgl	671	20	0	0	CD
cord-259603-bh198xgl	671	21	-O	-o	CD
cord-259603-bh198xgl	671	22	-	-	HYPH
cord-259603-bh198xgl	671	23	MTase	MTase	NNP
cord-259603-bh198xgl	671	24	(	(	-LRB-
cord-259603-bh198xgl	671	25	Decroly	Decroly	NNP
cord-259603-bh198xgl	671	26	et	et	NNP
cord-259603-bh198xgl	671	27	al	al	NNP
cord-259603-bh198xgl	671	28	.	.	NNP
cord-259603-bh198xgl	671	29	,	,	,
cord-259603-bh198xgl	671	30	2011	2011	CD
cord-259603-bh198xgl	671	31	)	)	-RRB-
cord-259603-bh198xgl	671	32	and	and	CC
cord-259603-bh198xgl	671	33	showed	show	VBD
cord-259603-bh198xgl	671	34	that	that	IN
cord-259603-bh198xgl	671	35	the	the	DT
cord-259603-bh198xgl	671	36	nsp10-nsp16	nsp10-nsp16	CD
cord-259603-bh198xgl	671	37	interaction	interaction	NN
cord-259603-bh198xgl	671	38	is	be	VBZ
cord-259603-bh198xgl	671	39	absolutely	absolutely	RB
cord-259603-bh198xgl	671	40	required	require	VBN
cord-259603-bh198xgl	671	41	for	for	IN
cord-259603-bh198xgl	671	42	activity	activity	NN
cord-259603-bh198xgl	671	43	(	(	-LRB-
cord-259603-bh198xgl	671	44	Decroly	Decroly	NNP
cord-259603-bh198xgl	671	45	et	et	NNP
cord-259603-bh198xgl	671	46	al	al	NNP
cord-259603-bh198xgl	671	47	.	.	NNP
cord-259603-bh198xgl	671	48	,	,	,
cord-259603-bh198xgl	671	49	2011	2011	CD
cord-259603-bh198xgl	671	50	;	;	:
cord-259603-bh198xgl	672	1	Lugari	Lugari	NNP
cord-259603-bh198xgl	672	2	et	et	IN
cord-259603-bh198xgl	672	3	al	al	NNP
cord-259603-bh198xgl	672	4	.	.	NNP
cord-259603-bh198xgl	672	5	,	,	,
cord-259603-bh198xgl	672	6	2010	2010	CD
cord-259603-bh198xgl	672	7	)	)	-RRB-
cord-259603-bh198xgl	672	8	.	.	.
cord-259603-bh198xgl	673	1	Crystallographic	crystallographic	JJ
cord-259603-bh198xgl	673	2	studies	study	NNS
cord-259603-bh198xgl	673	3	of	of	IN
cord-259603-bh198xgl	673	4	the	the	DT
cord-259603-bh198xgl	673	5	nsp10	nsp10	NNPS
cord-259603-bh198xgl	673	6	/	/	SYM
cord-259603-bh198xgl	673	7	nsp16	nsp16	NNS
cord-259603-bh198xgl	673	8	complex	complex	NN
cord-259603-bh198xgl	673	9	revealed	reveal	VBD
cord-259603-bh198xgl	673	10	the	the	DT
cord-259603-bh198xgl	673	11	molecular	molecular	JJ
cord-259603-bh198xgl	673	12	basis	basis	NN
cord-259603-bh198xgl	673	13	for	for	IN
cord-259603-bh198xgl	673	14	the	the	DT
cord-259603-bh198xgl	673	15	stimulation	stimulation	NN
cord-259603-bh198xgl	673	16	of	of	IN
cord-259603-bh198xgl	673	17	the	the	DT
cord-259603-bh198xgl	673	18	nsp16	nsp16	NNS
cord-259603-bh198xgl	673	19	2	2	CD
cord-259603-bh198xgl	673	20	0	0	CD
cord-259603-bh198xgl	673	21	-O	-o	CD
cord-259603-bh198xgl	673	22	-	-	HYPH
cord-259603-bh198xgl	673	23	MTase	mtase	JJ
cord-259603-bh198xgl	673	24	activity	activity	NN
cord-259603-bh198xgl	673	25	by	by	IN
cord-259603-bh198xgl	673	26	nsp10	nsp10	XX
cord-259603-bh198xgl	674	1	(	(	-LRB-
cord-259603-bh198xgl	674	2	Fig	Fig	NNP
cord-259603-bh198xgl	674	3	.	.	.
cord-259603-bh198xgl	675	1	7	7	LS
cord-259603-bh198xgl	675	2	)	)	-RRB-
cord-259603-bh198xgl	675	3	(	(	-LRB-
cord-259603-bh198xgl	675	4	Chen	Chen	NNP
cord-259603-bh198xgl	675	5	et	et	NNP
cord-259603-bh198xgl	675	6	al	al	NNP
cord-259603-bh198xgl	675	7	.	.	NNP
cord-259603-bh198xgl	675	8	,	,	,
cord-259603-bh198xgl	675	9	2011	2011	CD
cord-259603-bh198xgl	675	10	;	;	:
cord-259603-bh198xgl	675	11	Decroly	Decroly	NNP
cord-259603-bh198xgl	675	12	et	et	NNP
cord-259603-bh198xgl	675	13	al	al	NNP
cord-259603-bh198xgl	675	14	.	.	NNP
cord-259603-bh198xgl	675	15	,	,	,
cord-259603-bh198xgl	675	16	2011	2011	CD
cord-259603-bh198xgl	675	17	)	)	-RRB-
cord-259603-bh198xgl	675	18	.	.	.
cord-259603-bh198xgl	676	1	The	the	DT
cord-259603-bh198xgl	676	2	CoV	cov	NN
cord-259603-bh198xgl	676	3	2	2	CD
cord-259603-bh198xgl	676	4	0	0	CD
cord-259603-bh198xgl	676	5	-O	-O	:
cord-259603-bh198xgl	676	6	-	-	HYPH
cord-259603-bh198xgl	676	7	MTase	MTase	NNP
cord-259603-bh198xgl	676	8	belongs	belong	VBZ
cord-259603-bh198xgl	676	9	to	to	IN
cord-259603-bh198xgl	676	10	the	the	DT
cord-259603-bh198xgl	676	11	RrmJ	RrmJ	NNP
cord-259603-bh198xgl	676	12	/	/	SYM
cord-259603-bh198xgl	676	13	fibrillarin	fibrillarin	NNP
cord-259603-bh198xgl	676	14	superfamily	superfamily	NN
cord-259603-bh198xgl	676	15	of	of	IN
cord-259603-bh198xgl	676	16	ribose	ribose	NN
cord-259603-bh198xgl	676	17	2	2	CD
cord-259603-bh198xgl	676	18	0	0	CD
cord-259603-bh198xgl	676	19	-O	-o	CD
cord-259603-bh198xgl	676	20	-	-	HYPH
cord-259603-bh198xgl	676	21	methyl	methyl	JJ
cord-259603-bh198xgl	676	22	transferases	transferase	NNS
cord-259603-bh198xgl	676	23	(	(	-LRB-
cord-259603-bh198xgl	676	24	Feder	Feder	NNP
cord-259603-bh198xgl	676	25	et	et	NNP
cord-259603-bh198xgl	676	26	al	al	NNP
cord-259603-bh198xgl	676	27	.	.	NNP
cord-259603-bh198xgl	676	28	,	,	,
cord-259603-bh198xgl	676	29	2003	2003	CD
cord-259603-bh198xgl	676	30	)	)	-RRB-
cord-259603-bh198xgl	676	31	which	which	WDT
cord-259603-bh198xgl	676	32	have	have	VBP
cord-259603-bh198xgl	676	33	a	a	DT
cord-259603-bh198xgl	676	34	number	number	NN
cord-259603-bh198xgl	676	35	of	of	IN
cord-259603-bh198xgl	676	36	viral	viral	JJ
cord-259603-bh198xgl	676	37	orthologs	ortholog	NNS
cord-259603-bh198xgl	676	38	in	in	IN
cord-259603-bh198xgl	676	39	flaviviruses	flavivirus	NNS
cord-259603-bh198xgl	676	40	,	,	,
cord-259603-bh198xgl	676	41	alphaviruses	alphaviruses	NNP
cord-259603-bh198xgl	676	42	,	,	,
cord-259603-bh198xgl	676	43	and	and	CC
cord-259603-bh198xgl	676	44	other	other	JJ
cord-259603-bh198xgl	676	45	nidoviruses	nidoviruse	NNS
cord-259603-bh198xgl	676	46	.	.	.
cord-259603-bh198xgl	677	1	As	as	IN
cord-259603-bh198xgl	677	2	mentioned	mention	VBN
cord-259603-bh198xgl	677	3	earlier	early	RBR
cord-259603-bh198xgl	677	4	,	,	,
cord-259603-bh198xgl	677	5	this	this	DT
cord-259603-bh198xgl	677	6	family	family	NN
cord-259603-bh198xgl	677	7	contains	contain	VBZ
cord-259603-bh198xgl	677	8	a	a	DT
cord-259603-bh198xgl	677	9	conserved	conserve	VBN
cord-259603-bh198xgl	677	10	K	K	NNP
cord-259603-bh198xgl	677	11	-	-	HYPH
cord-259603-bh198xgl	677	12	D	D	NNP
cord-259603-bh198xgl	677	13	-	-	HYPH
cord-259603-bh198xgl	677	14	K	k	NN
cord-259603-bh198xgl	677	15	-	-	HYPH
cord-259603-bh198xgl	677	16	E	e	NN
cord-259603-bh198xgl	677	17	catalytic	catalytic	JJ
cord-259603-bh198xgl	677	18	tetrad	tetrad	NN
cord-259603-bh198xgl	677	19	(	(	-LRB-
cord-259603-bh198xgl	677	20	Fig	Fig	NNP
cord-259603-bh198xgl	677	21	.	.	NNP
cord-259603-bh198xgl	677	22	7	7	CD
cord-259603-bh198xgl	677	23	)	)	-RRB-
cord-259603-bh198xgl	677	24	that	that	WDT
cord-259603-bh198xgl	677	25	is	be	VBZ
cord-259603-bh198xgl	677	26	located	locate	VBN
cord-259603-bh198xgl	677	27	in	in	IN
cord-259603-bh198xgl	677	28	close	close	JJ
cord-259603-bh198xgl	677	29	proximity	proximity	NN
cord-259603-bh198xgl	677	30	to	to	IN
cord-259603-bh198xgl	677	31	the	the	DT
cord-259603-bh198xgl	677	32	substrate	substrate	NN
cord-259603-bh198xgl	677	33	-	-	HYPH
cord-259603-bh198xgl	677	34	binding	bind	VBG
cord-259603-bh198xgl	677	35	pocket	pocket	NN
cord-259603-bh198xgl	677	36	accommodating	accommodate	VBG
cord-259603-bh198xgl	677	37	the	the	DT
cord-259603-bh198xgl	677	38	RNA	RNA	NNP
cord-259603-bh198xgl	677	39	substrate	substrate	NN
cord-259603-bh198xgl	677	40	.	.	.
cord-259603-bh198xgl	678	1	The	the	DT
cord-259603-bh198xgl	678	2	structure	structure	NN
cord-259603-bh198xgl	678	3	revealed	reveal	VBD
cord-259603-bh198xgl	678	4	that	that	IN
cord-259603-bh198xgl	678	5	nsp10	nsp10	NNPS
cord-259603-bh198xgl	678	6	is	be	VBZ
cord-259603-bh198xgl	678	7	an	an	DT
cord-259603-bh198xgl	678	8	allosteric	allosteric	JJ
cord-259603-bh198xgl	678	9	regulator	regulator	NN
cord-259603-bh198xgl	678	10	that	that	WDT
cord-259603-bh198xgl	678	11	stabilizes	stabilize	VBZ
cord-259603-bh198xgl	678	12	nsp16	nsp16	NNS
cord-259603-bh198xgl	678	13	.	.	.
cord-259603-bh198xgl	679	1	Moreover	moreover	RB
cord-259603-bh198xgl	679	2	,	,	,
cord-259603-bh198xgl	679	3	structural	structural	JJ
cord-259603-bh198xgl	679	4	and	and	CC
cord-259603-bh198xgl	679	5	biochemical	biochemical	JJ
cord-259603-bh198xgl	679	6	analyses	analysis	NNS
cord-259603-bh198xgl	679	7	indicated	indicate	VBD
cord-259603-bh198xgl	679	8	that	that	IN
cord-259603-bh198xgl	679	9	nsp10	nsp10	RB
cord-259603-bh198xgl	679	10	binding	bind	VBG
cord-259603-bh198xgl	679	11	extends	extend	NNS
cord-259603-bh198xgl	679	12	and	and	CC
cord-259603-bh198xgl	679	13	narrows	narrow	VBZ
cord-259603-bh198xgl	679	14	the	the	DT
cord-259603-bh198xgl	679	15	RNA	RNA	NNP
cord-259603-bh198xgl	679	16	-	-	HYPH
cord-259603-bh198xgl	679	17	binding	bind	VBG
cord-259603-bh198xgl	679	18	groove	groove	NN
cord-259603-bh198xgl	679	19	that	that	WDT
cord-259603-bh198xgl	679	20	accommodates	accommodate	VBZ
cord-259603-bh198xgl	679	21	the	the	DT
cord-259603-bh198xgl	679	22	RNA	RNA	NNP
cord-259603-bh198xgl	679	23	substrate	substrate	NN
cord-259603-bh198xgl	679	24	,	,	,
cord-259603-bh198xgl	679	25	thereby	thereby	RB
cord-259603-bh198xgl	679	26	promoting	promote	VBG
cord-259603-bh198xgl	679	27	the	the	DT
cord-259603-bh198xgl	679	28	RNAand	RNAand	NNP
cord-259603-bh198xgl	679	29	AdoMet	AdoMet	NNP
cord-259603-bh198xgl	679	30	-	-	HYPH
cord-259603-bh198xgl	679	31	binding	bind	VBG
cord-259603-bh198xgl	679	32	capabilities	capability	NNS
cord-259603-bh198xgl	679	33	of	of	IN
cord-259603-bh198xgl	679	34	nsp16	nsp16	NNS
cord-259603-bh198xgl	680	1	(	(	-LRB-
cord-259603-bh198xgl	680	2	Fig	Fig	NNP
cord-259603-bh198xgl	680	3	.	.	.
cord-259603-bh198xgl	681	1	7	7	LS
cord-259603-bh198xgl	681	2	)	)	-RRB-
cord-259603-bh198xgl	681	3	.	.	.
cord-259603-bh198xgl	681	4	)	)	-RRB-
cord-259603-bh198xgl	681	5	,	,	,
cord-259603-bh198xgl	681	6	and	and	CC
cord-259603-bh198xgl	681	7	IBV	IBV	NNP
cord-259603-bh198xgl	681	8	(	(	-LRB-
cord-259603-bh198xgl	681	9	genus	genus	NN
cord-259603-bh198xgl	681	10	Gammacoronavirus	Gammacoronavirus	NNP
cord-259603-bh198xgl	681	11	)	)	-RRB-
cord-259603-bh198xgl	681	12	.	.	.
cord-259603-bh198xgl	682	1	The	the	DT
cord-259603-bh198xgl	682	2	alignment	alignment	NN
cord-259603-bh198xgl	682	3	was	be	VBD
cord-259603-bh198xgl	682	4	generated	generate	VBN
cord-259603-bh198xgl	682	5	using	use	VBG
cord-259603-bh198xgl	682	6	Clustal	Clustal	NNP
cord-259603-bh198xgl	682	7	Omega	Omega	NNP
cord-259603-bh198xgl	682	8	(	(	-LRB-
cord-259603-bh198xgl	682	9	Sievers	Sievers	NNP
cord-259603-bh198xgl	682	10	et	et	NNP
cord-259603-bh198xgl	682	11	al	al	NNP
cord-259603-bh198xgl	682	12	.	.	NNP
cord-259603-bh198xgl	682	13	,	,	,
cord-259603-bh198xgl	682	14	2011	2011	CD
cord-259603-bh198xgl	682	15	)	)	-RRB-
cord-259603-bh198xgl	682	16	and	and	CC
cord-259603-bh198xgl	682	17	rendered	render	VBN
cord-259603-bh198xgl	682	18	using	use	VBG
cord-259603-bh198xgl	682	19	ESPript	ESPript	NNP
cord-259603-bh198xgl	682	20	version	version	NN
cord-259603-bh198xgl	682	21	3.0	3.0	CD
cord-259603-bh198xgl	682	22	(	(	-LRB-
cord-259603-bh198xgl	682	23	Robert	Robert	NNP
cord-259603-bh198xgl	682	24	and	and	CC
cord-259603-bh198xgl	682	25	Gouet	Gouet	NNP
cord-259603-bh198xgl	682	26	,	,	,
cord-259603-bh198xgl	682	27	2014	2014	CD
cord-259603-bh198xgl	682	28	)	)	-RRB-
cord-259603-bh198xgl	682	29	.	.	.
cord-259603-bh198xgl	683	1	Residues	residue	NNS
cord-259603-bh198xgl	683	2	of	of	IN
cord-259603-bh198xgl	683	3	the	the	DT
cord-259603-bh198xgl	683	4	catalytic	catalytic	JJ
cord-259603-bh198xgl	683	5	tetrad	tetrad	NN
cord-259603-bh198xgl	683	6	K	K	NNP
cord-259603-bh198xgl	683	7	-	-	HYPH
cord-259603-bh198xgl	683	8	D	D	NNP
cord-259603-bh198xgl	683	9	-	-	HYPH
cord-259603-bh198xgl	683	10	K	k	NN
cord-259603-bh198xgl	683	11	-	-	HYPH
cord-259603-bh198xgl	683	12	E	E	NNP
cord-259603-bh198xgl	683	13	are	be	VBP
cord-259603-bh198xgl	683	14	indicated	indicate	VBN
cord-259603-bh198xgl	683	15	by	by	IN
cord-259603-bh198xgl	683	16	asterisks	asterisk	NNS
cord-259603-bh198xgl	683	17	and	and	CC
cord-259603-bh198xgl	683	18	secondary	secondary	JJ
cord-259603-bh198xgl	683	19	structure	structure	NN
cord-259603-bh198xgl	683	20	elements	element	NNS
cord-259603-bh198xgl	683	21	of	of	IN
cord-259603-bh198xgl	683	22	SARS	SARS	NNP
cord-259603-bh198xgl	683	23	-	-	HYPH
cord-259603-bh198xgl	683	24	CoV	CoV	NNP
cord-259603-bh198xgl	683	25	nsp16	nsp16	NNS
cord-259603-bh198xgl	683	26	(	(	-LRB-
cord-259603-bh198xgl	683	27	pdb	pdb	NNP
cord-259603-bh198xgl	683	28	2XYV	2XYV	NNP
cord-259603-bh198xgl	683	29	)	)	-RRB-
cord-259603-bh198xgl	683	30	are	be	VBP
cord-259603-bh198xgl	683	31	shown	show	VBN
cord-259603-bh198xgl	683	32	.	.	.
cord-259603-bh198xgl	684	1	(	(	-LRB-
cord-259603-bh198xgl	684	2	B	b	NN
cord-259603-bh198xgl	684	3	)	)	-RRB-
cord-259603-bh198xgl	684	4	Surface	surface	NN
cord-259603-bh198xgl	684	5	representation	representation	NN
cord-259603-bh198xgl	684	6	of	of	IN
cord-259603-bh198xgl	684	7	the	the	DT
cord-259603-bh198xgl	684	8	three	three	CD
cord-259603-bh198xgl	684	9	-	-	HYPH
cord-259603-bh198xgl	684	10	dimensional	dimensional	JJ
cord-259603-bh198xgl	684	11	structure	structure	NN
cord-259603-bh198xgl	684	12	of	of	IN
cord-259603-bh198xgl	684	13	the	the	DT
cord-259603-bh198xgl	685	1	nsp10	nsp10	NNP
cord-259603-bh198xgl	685	2	/	/	SYM
cord-259603-bh198xgl	685	3	nsp16	nsp16	NNS
cord-259603-bh198xgl	685	4	(	(	-LRB-
cord-259603-bh198xgl	685	5	Continued	continue	VBN
cord-259603-bh198xgl	685	6	)	)	-RRB-
cord-259603-bh198xgl	686	1	The	the	DT
cord-259603-bh198xgl	686	2	functional	functional	JJ
cord-259603-bh198xgl	686	3	relevance	relevance	NN
cord-259603-bh198xgl	686	4	of	of	IN
cord-259603-bh198xgl	686	5	2	2	CD
cord-259603-bh198xgl	686	6	0	0	CD
cord-259603-bh198xgl	686	7	-O	-o	CD
cord-259603-bh198xgl	686	8	-	-	HYPH
cord-259603-bh198xgl	686	9	MTase	mtase	JJ
cord-259603-bh198xgl	686	10	regulation	regulation	NN
cord-259603-bh198xgl	686	11	by	by	IN
cord-259603-bh198xgl	686	12	nsp10	nsp10	NNPS
cord-259603-bh198xgl	686	13	for	for	IN
cord-259603-bh198xgl	686	14	virus	virus	NN
cord-259603-bh198xgl	686	15	replication	replication	NN
cord-259603-bh198xgl	686	16	is	be	VBZ
cord-259603-bh198xgl	686	17	not	not	RB
cord-259603-bh198xgl	686	18	yet	yet	RB
cord-259603-bh198xgl	686	19	understood	understand	VBN
cord-259603-bh198xgl	686	20	.	.	.
cord-259603-bh198xgl	687	1	The	the	DT
cord-259603-bh198xgl	687	2	nsp16-associated	nsp16-associated	JJ
cord-259603-bh198xgl	687	3	2	2	CD
cord-259603-bh198xgl	687	4	0	0	CD
cord-259603-bh198xgl	687	5	-O	-o	CD
cord-259603-bh198xgl	687	6	-	-	HYPH
cord-259603-bh198xgl	687	7	MTase	mtase	JJ
cord-259603-bh198xgl	687	8	activity	activity	NN
cord-259603-bh198xgl	687	9	(	(	-LRB-
cord-259603-bh198xgl	687	10	itself	itself	NN
cord-259603-bh198xgl	687	11	)	)	-RRB-
cord-259603-bh198xgl	687	12	is	be	VBZ
cord-259603-bh198xgl	687	13	highly	highly	RB
cord-259603-bh198xgl	687	14	conserved	conserve	VBN
cord-259603-bh198xgl	687	15	across	across	IN
cord-259603-bh198xgl	687	16	the	the	DT
cord-259603-bh198xgl	687	17	Coronaviridae	Coronaviridae	NNP
cord-259603-bh198xgl	687	18	family	family	NN
cord-259603-bh198xgl	687	19	and	and	CC
cord-259603-bh198xgl	687	20	its	-PRON-	PRP$
cord-259603-bh198xgl	687	21	functional	functional	JJ
cord-259603-bh198xgl	687	22	relevance	relevance	NN
cord-259603-bh198xgl	687	23	has	have	VBZ
cord-259603-bh198xgl	687	24	been	be	VBN
cord-259603-bh198xgl	687	25	supported	support	VBN
cord-259603-bh198xgl	687	26	by	by	IN
cord-259603-bh198xgl	687	27	reverse	reverse	JJ
cord-259603-bh198xgl	687	28	-	-	HYPH
cord-259603-bh198xgl	687	29	genetics	genetics	NN
cord-259603-bh198xgl	687	30	studies	study	NNS
cord-259603-bh198xgl	687	31	using	use	VBG
cord-259603-bh198xgl	687	32	genetically	genetically	RB
cord-259603-bh198xgl	687	33	engineered	engineer	VBN
cord-259603-bh198xgl	687	34	alpha	alpha	NN
cord-259603-bh198xgl	687	35	-	-	HYPH
cord-259603-bh198xgl	687	36	and	and	CC
cord-259603-bh198xgl	687	37	betacoronavirus	betacoronavirus	NN
cord-259603-bh198xgl	687	38	mutants	mutant	NNS
cord-259603-bh198xgl	687	39	that	that	WDT
cord-259603-bh198xgl	687	40	lack	lack	VBP
cord-259603-bh198xgl	687	41	2	2	CD
cord-259603-bh198xgl	687	42	0	0	CD
cord-259603-bh198xgl	687	43	-O	-o	CD
cord-259603-bh198xgl	687	44	-	-	HYPH
cord-259603-bh198xgl	687	45	MTase	mtase	JJ
cord-259603-bh198xgl	687	46	activity	activity	NN
cord-259603-bh198xgl	687	47	(	(	-LRB-
cord-259603-bh198xgl	687	48	Devarkar	Devarkar	NNP
cord-259603-bh198xgl	687	49	et	et	FW
cord-259603-bh198xgl	687	50	al	al	NNP
cord-259603-bh198xgl	687	51	.	.	NNP
cord-259603-bh198xgl	687	52	,	,	,
cord-259603-bh198xgl	687	53	2016	2016	CD
cord-259603-bh198xgl	687	54	;	;	:
cord-259603-bh198xgl	687	55	Hyde	Hyde	NNP
cord-259603-bh198xgl	687	56	and	and	CC
cord-259603-bh198xgl	687	57	Diamond	Diamond	NNP
cord-259603-bh198xgl	687	58	,	,	,
cord-259603-bh198xgl	687	59	2015	2015	CD
cord-259603-bh198xgl	687	60	;	;	.
cord-259603-bh198xgl	688	1	Schuberth	Schuberth	NNP
cord-259603-bh198xgl	688	2	-	-	HYPH
cord-259603-bh198xgl	688	3	Wagner	Wagner	NNP
cord-259603-bh198xgl	688	4	et	et	NNP
cord-259603-bh198xgl	688	5	al	al	NNP
cord-259603-bh198xgl	688	6	.	.	NNP
cord-259603-bh198xgl	688	7	,	,	,
cord-259603-bh198xgl	688	8	2015	2015	CD
cord-259603-bh198xgl	688	9	;	;	:
cord-259603-bh198xgl	688	10	Z€	Z€	NNP
cord-259603-bh198xgl	688	11	ust	ust	NNP
cord-259603-bh198xgl	688	12	et	et	NNP
cord-259603-bh198xgl	688	13	al	al	NNP
cord-259603-bh198xgl	688	14	.	.	NNP
cord-259603-bh198xgl	688	15	,	,	,
cord-259603-bh198xgl	688	16	2011	2011	CD
cord-259603-bh198xgl	688	17	)	)	-RRB-
cord-259603-bh198xgl	688	18	.	.	.
cord-259603-bh198xgl	689	1	Furthermore	furthermore	RB
cord-259603-bh198xgl	689	2	,	,	,
cord-259603-bh198xgl	689	3	the	the	DT
cord-259603-bh198xgl	689	4	phenotype	phenotype	NN
cord-259603-bh198xgl	689	5	of	of	IN
cord-259603-bh198xgl	689	6	temperature	temperature	NN
cord-259603-bh198xgl	689	7	-	-	HYPH
cord-259603-bh198xgl	689	8	sensitive	sensitive	JJ
cord-259603-bh198xgl	689	9	MHV	MHV	NNP
cord-259603-bh198xgl	689	10	mutants	mutant	NNS
cord-259603-bh198xgl	689	11	suggested	suggest	VBD
cord-259603-bh198xgl	689	12	nsp16	nsp16	NNS
cord-259603-bh198xgl	689	13	to	to	TO
cord-259603-bh198xgl	689	14	play	play	VB
cord-259603-bh198xgl	689	15	a	a	DT
cord-259603-bh198xgl	689	16	role	role	NN
cord-259603-bh198xgl	689	17	in	in	IN
cord-259603-bh198xgl	689	18	RNA	RNA	NNP
cord-259603-bh198xgl	689	19	synthesis	synthesis	NN
cord-259603-bh198xgl	689	20	or	or	CC
cord-259603-bh198xgl	689	21	in	in	IN
cord-259603-bh198xgl	689	22	the	the	DT
cord-259603-bh198xgl	689	23	stability	stability	NN
cord-259603-bh198xgl	689	24	of	of	IN
cord-259603-bh198xgl	689	25	plus	plus	JJ
cord-259603-bh198xgl	689	26	-	-	HYPH
cord-259603-bh198xgl	689	27	strand	strand	NN
cord-259603-bh198xgl	689	28	RNA	RNA	NNP
cord-259603-bh198xgl	690	1	(	(	-LRB-
cord-259603-bh198xgl	690	2	Sawicki	Sawicki	NNP
cord-259603-bh198xgl	690	3	et	et	NNP
cord-259603-bh198xgl	690	4	al	al	NNP
cord-259603-bh198xgl	690	5	.	.	NNP
cord-259603-bh198xgl	690	6	,	,	,
cord-259603-bh198xgl	690	7	2005	2005	CD
cord-259603-bh198xgl	690	8	)	)	-RRB-
cord-259603-bh198xgl	690	9	.	.	.
cord-259603-bh198xgl	691	1	An	an	DT
cord-259603-bh198xgl	691	2	early	early	JJ
cord-259603-bh198xgl	691	3	SARS	SARS	NNP
cord-259603-bh198xgl	691	4	-	-	HYPH
cord-259603-bh198xgl	691	5	CoV	CoV	NNP
cord-259603-bh198xgl	691	6	study	study	NN
cord-259603-bh198xgl	691	7	was	be	VBD
cord-259603-bh198xgl	691	8	able	able	JJ
cord-259603-bh198xgl	691	9	to	to	TO
cord-259603-bh198xgl	691	10	show	show	VB
cord-259603-bh198xgl	691	11	that	that	IN
cord-259603-bh198xgl	691	12	the	the	DT
cord-259603-bh198xgl	691	13	insertion	insertion	NN
cord-259603-bh198xgl	691	14	of	of	IN
cord-259603-bh198xgl	691	15	a	a	DT
cord-259603-bh198xgl	691	16	stop	stop	NN
cord-259603-bh198xgl	691	17	codon	codon	NN
cord-259603-bh198xgl	691	18	immediately	immediately	RB
cord-259603-bh198xgl	691	19	upstream	upstream	RB
cord-259603-bh198xgl	691	20	of	of	IN
cord-259603-bh198xgl	691	21	the	the	DT
cord-259603-bh198xgl	691	22	nsp16-coding	nsp16-coding	NN
cord-259603-bh198xgl	691	23	sequence	sequence	NN
cord-259603-bh198xgl	691	24	blocked	block	VBD
cord-259603-bh198xgl	691	25	viral	viral	JJ
cord-259603-bh198xgl	691	26	RNA	RNA	NNP
cord-259603-bh198xgl	691	27	synthesis	synthesis	NN
cord-259603-bh198xgl	691	28	(	(	-LRB-
cord-259603-bh198xgl	691	29	Almazan	Almazan	NNP
cord-259603-bh198xgl	691	30	et	et	NNP
cord-259603-bh198xgl	691	31	al	al	NNP
cord-259603-bh198xgl	691	32	.	.	NNP
cord-259603-bh198xgl	691	33	,	,	,
cord-259603-bh198xgl	691	34	2006	2006	CD
cord-259603-bh198xgl	691	35	)	)	-RRB-
cord-259603-bh198xgl	691	36	.	.	.
cord-259603-bh198xgl	692	1	Subsequently	subsequently	RB
cord-259603-bh198xgl	692	2	,	,	,
cord-259603-bh198xgl	692	3	for	for	IN
cord-259603-bh198xgl	692	4	HCoV-229E	HCoV-229E	NNP
cord-259603-bh198xgl	692	5	,	,	,
cord-259603-bh198xgl	692	6	MHV	MHV	NNP
cord-259603-bh198xgl	692	7	,	,	,
cord-259603-bh198xgl	692	8	and	and	CC
cord-259603-bh198xgl	692	9	SARS	SARS	NNP
cord-259603-bh198xgl	692	10	-	-	HYPH
cord-259603-bh198xgl	692	11	CoV	CoV	NNP
cord-259603-bh198xgl	692	12	,	,	,
cord-259603-bh198xgl	692	13	several	several	JJ
cord-259603-bh198xgl	692	14	mutants	mutant	NNS
cord-259603-bh198xgl	692	15	with	with	IN
cord-259603-bh198xgl	692	16	reduced	reduced	JJ
cord-259603-bh198xgl	692	17	or	or	CC
cord-259603-bh198xgl	692	18	ablated	ablate	VBN
cord-259603-bh198xgl	692	19	2	2	CD
cord-259603-bh198xgl	692	20	0	0	CD
cord-259603-bh198xgl	692	21	-O	-o	CD
cord-259603-bh198xgl	692	22	-	-	HYPH
cord-259603-bh198xgl	692	23	MTase	mtase	JJ
cord-259603-bh198xgl	692	24	activity	activity	NN
cord-259603-bh198xgl	692	25	were	be	VBD
cord-259603-bh198xgl	692	26	described	describe	VBN
cord-259603-bh198xgl	692	27	that	that	IN
cord-259603-bh198xgl	692	28	generally	generally	RB
cord-259603-bh198xgl	692	29	retained	retain	VBD
cord-259603-bh198xgl	692	30	robust	robust	JJ
cord-259603-bh198xgl	692	31	viral	viral	JJ
cord-259603-bh198xgl	692	32	replication	replication	NN
cord-259603-bh198xgl	692	33	in	in	IN
cord-259603-bh198xgl	692	34	cell	cell	NN
cord-259603-bh198xgl	692	35	culture	culture	NN
cord-259603-bh198xgl	693	1	(	(	-LRB-
cord-259603-bh198xgl	693	2	Menachery	Menachery	NNP
cord-259603-bh198xgl	693	3	et	et	NNP
cord-259603-bh198xgl	693	4	al	al	NNP
cord-259603-bh198xgl	693	5	.	.	.
cord-259603-bh198xgl	694	1	,	,	,
cord-259603-bh198xgl	694	2	2014	2014	CD
cord-259603-bh198xgl	694	3	;	;	:
cord-259603-bh198xgl	694	4	Z€	Z€	NNP
cord-259603-bh198xgl	694	5	ust	ust	NNP
cord-259603-bh198xgl	694	6	et	et	NNP
cord-259603-bh198xgl	694	7	al	al	NNP
cord-259603-bh198xgl	694	8	.	.	NNP
cord-259603-bh198xgl	694	9	,	,	,
cord-259603-bh198xgl	694	10	2011	2011	CD
cord-259603-bh198xgl	694	11	)	)	-RRB-
cord-259603-bh198xgl	694	12	.	.	.
cord-259603-bh198xgl	695	1	The	the	DT
cord-259603-bh198xgl	695	2	studies	study	NNS
cord-259603-bh198xgl	695	3	also	also	RB
cord-259603-bh198xgl	695	4	revealed	reveal	VBD
cord-259603-bh198xgl	695	5	that	that	IN
cord-259603-bh198xgl	695	6	the	the	DT
cord-259603-bh198xgl	695	7	impact	impact	NN
cord-259603-bh198xgl	695	8	of	of	IN
cord-259603-bh198xgl	695	9	nsp16	nsp16	NNS
cord-259603-bh198xgl	695	10	mutations	mutation	NNS
cord-259603-bh198xgl	695	11	may	may	MD
cord-259603-bh198xgl	695	12	depend	depend	VB
cord-259603-bh198xgl	695	13	on	on	IN
cord-259603-bh198xgl	695	14	the	the	DT
cord-259603-bh198xgl	695	15	cell	cell	NN
cord-259603-bh198xgl	695	16	types	type	NNS
cord-259603-bh198xgl	695	17	used	use	VBN
cord-259603-bh198xgl	695	18	and	and	CC
cord-259603-bh198xgl	695	19	that	that	IN
cord-259603-bh198xgl	695	20	the	the	DT
cord-259603-bh198xgl	695	21	lack	lack	NN
cord-259603-bh198xgl	695	22	of	of	IN
cord-259603-bh198xgl	695	23	2	2	CD
cord-259603-bh198xgl	695	24	0	0	CD
cord-259603-bh198xgl	695	25	-O	-o	CD
cord-259603-bh198xgl	695	26	-	-	HYPH
cord-259603-bh198xgl	695	27	MTase	mtase	JJ
cord-259603-bh198xgl	695	28	activity	activity	NN
cord-259603-bh198xgl	695	29	causes	cause	VBZ
cord-259603-bh198xgl	695	30	more	more	RBR
cord-259603-bh198xgl	695	31	profound	profound	JJ
cord-259603-bh198xgl	695	32	effects	effect	NNS
cord-259603-bh198xgl	695	33	in	in	IN
cord-259603-bh198xgl	695	34	primary	primary	JJ
cord-259603-bh198xgl	695	35	cells	cell	NNS
cord-259603-bh198xgl	695	36	and	and	CC
cord-259603-bh198xgl	695	37	immune	immune	JJ
cord-259603-bh198xgl	695	38	cells	cell	NNS
cord-259603-bh198xgl	695	39	.	.	.
cord-259603-bh198xgl	696	1	The	the	DT
cord-259603-bh198xgl	696	2	SARS	SARS	NNP
cord-259603-bh198xgl	696	3	-	-	HYPH
cord-259603-bh198xgl	696	4	CoV	CoV	NNP
cord-259603-bh198xgl	696	5	nsp16	nsp16	NNS
cord-259603-bh198xgl	696	6	mutants	mutant	NNS
cord-259603-bh198xgl	696	7	were	be	VBD
cord-259603-bh198xgl	696	8	further	further	RB
cord-259603-bh198xgl	696	9	characterized	characterize	VBN
cord-259603-bh198xgl	696	10	in	in	IN
cord-259603-bh198xgl	696	11	infected	infected	JJ
cord-259603-bh198xgl	696	12	mice	mouse	NNS
cord-259603-bh198xgl	696	13	and	and	CC
cord-259603-bh198xgl	696	14	showed	show	VBD
cord-259603-bh198xgl	696	15	a	a	DT
cord-259603-bh198xgl	696	16	robust	robust	JJ
cord-259603-bh198xgl	696	17	attenuation	attenuation	NN
cord-259603-bh198xgl	696	18	as	as	IN
cord-259603-bh198xgl	696	19	judged	judge	VBN
cord-259603-bh198xgl	696	20	by	by	IN
cord-259603-bh198xgl	696	21	viral	viral	JJ
cord-259603-bh198xgl	696	22	titers	titer	NNS
cord-259603-bh198xgl	696	23	,	,	,
cord-259603-bh198xgl	696	24	weight	weight	NN
cord-259603-bh198xgl	696	25	loss	loss	NN
cord-259603-bh198xgl	696	26	,	,	,
cord-259603-bh198xgl	696	27	lung	lung	NN
cord-259603-bh198xgl	696	28	histology	histology	NN
cord-259603-bh198xgl	696	29	,	,	,
cord-259603-bh198xgl	696	30	and	and	CC
cord-259603-bh198xgl	696	31	respiratory	respiratory	JJ
cord-259603-bh198xgl	696	32	function	function	NN
cord-259603-bh198xgl	696	33	.	.	.
cord-259603-bh198xgl	697	1	The	the	DT
cord-259603-bh198xgl	697	2	nsp16	nsp16	NNS
cord-259603-bh198xgl	697	3	mutants	mutant	NNS
cord-259603-bh198xgl	697	4	also	also	RB
cord-259603-bh198xgl	697	5	displayed	display	VBD
cord-259603-bh198xgl	697	6	increased	increase	VBN
cord-259603-bh198xgl	697	7	sensitivity	sensitivity	NN
cord-259603-bh198xgl	697	8	to	to	IN
cord-259603-bh198xgl	697	9	treatment	treatment	NN
cord-259603-bh198xgl	697	10	with	with	IN
cord-259603-bh198xgl	697	11	type	type	NN
cord-259603-bh198xgl	697	12	I	-PRON-	PRP
cord-259603-bh198xgl	697	13	interferon	interferon	VBD
cord-259603-bh198xgl	697	14	.	.	.
cord-259603-bh198xgl	698	1	This	this	DT
cord-259603-bh198xgl	698	2	was	be	VBD
cord-259603-bh198xgl	698	3	also	also	RB
cord-259603-bh198xgl	698	4	observed	observe	VBN
cord-259603-bh198xgl	698	5	for	for	IN
cord-259603-bh198xgl	698	6	the	the	DT
cord-259603-bh198xgl	698	7	corresponding	corresponding	JJ
cord-259603-bh198xgl	698	8	MHV	MHV	NNP
cord-259603-bh198xgl	698	9	and	and	CC
cord-259603-bh198xgl	698	10	HCoV-229E	HCoV-229E	NNP
cord-259603-bh198xgl	698	11	nsp16	nsp16	NNS
cord-259603-bh198xgl	698	12	mutants	mutant	NNS
cord-259603-bh198xgl	698	13	(	(	-LRB-
cord-259603-bh198xgl	698	14	Z€	Z€	NNP
cord-259603-bh198xgl	698	15	ust	ust	NNP
cord-259603-bh198xgl	698	16	et	et	NNP
cord-259603-bh198xgl	698	17	al	al	NNP
cord-259603-bh198xgl	698	18	.	.	NNP
cord-259603-bh198xgl	698	19	,	,	,
cord-259603-bh198xgl	698	20	2011	2011	CD
cord-259603-bh198xgl	698	21	)	)	-RRB-
cord-259603-bh198xgl	698	22	.	.	.
cord-259603-bh198xgl	699	1	However	however	RB
cord-259603-bh198xgl	699	2	,	,	,
cord-259603-bh198xgl	699	3	in	in	IN
cord-259603-bh198xgl	699	4	contrast	contrast	NN
cord-259603-bh198xgl	699	5	to	to	IN
cord-259603-bh198xgl	699	6	the	the	DT
cord-259603-bh198xgl	699	7	latter	latter	JJ
cord-259603-bh198xgl	699	8	study	study	NN
cord-259603-bh198xgl	699	9	,	,	,
cord-259603-bh198xgl	699	10	the	the	DT
cord-259603-bh198xgl	699	11	SARS	SARS	NNP
cord-259603-bh198xgl	699	12	-	-	HYPH
cord-259603-bh198xgl	699	13	CoV	CoV	NNP
cord-259603-bh198xgl	699	14	nsp16	nsp16	NNS
cord-259603-bh198xgl	699	15	mutant	mutant	NN
cord-259603-bh198xgl	699	16	was	be	VBD
cord-259603-bh198xgl	699	17	not	not	RB
cord-259603-bh198xgl	699	18	found	find	VBN
cord-259603-bh198xgl	699	19	to	to	TO
cord-259603-bh198xgl	699	20	induce	induce	VB
cord-259603-bh198xgl	699	21	type	type	NN
cord-259603-bh198xgl	699	22	I	-PRON-	PRP
cord-259603-bh198xgl	699	23	interferons	interferon	NNS
cord-259603-bh198xgl	699	24	,	,	,
cord-259603-bh198xgl	699	25	either	either	CC
cord-259603-bh198xgl	699	26	in	in	IN
cord-259603-bh198xgl	699	27	vitro	vitro	FW
cord-259603-bh198xgl	699	28	or	or	CC
cord-259603-bh198xgl	699	29	in	in	IN
cord-259603-bh198xgl	699	30	vivo	vivo	NN
cord-259603-bh198xgl	700	1	(	(	-LRB-
cord-259603-bh198xgl	700	2	Menachery	Menachery	NNP
cord-259603-bh198xgl	700	3	et	et	NNP
cord-259603-bh198xgl	700	4	al	al	NNP
cord-259603-bh198xgl	700	5	.	.	NNP
cord-259603-bh198xgl	700	6	,	,	,
cord-259603-bh198xgl	700	7	2014	2014	CD
cord-259603-bh198xgl	700	8	)	)	-RRB-
cord-259603-bh198xgl	700	9	.	.	.
cord-259603-bh198xgl	701	1	This	this	DT
cord-259603-bh198xgl	701	2	observation	observation	NN
cord-259603-bh198xgl	701	3	suggests	suggest	VBZ
cord-259603-bh198xgl	701	4	that	that	IN
cord-259603-bh198xgl	701	5	SARS	SARS	NNP
cord-259603-bh198xgl	701	6	-	-	HYPH
cord-259603-bh198xgl	701	7	CoV	CoV	NNP
cord-259603-bh198xgl	701	8	may	may	MD
cord-259603-bh198xgl	701	9	have	have	VB
cord-259603-bh198xgl	701	10	a	a	DT
cord-259603-bh198xgl	701	11	larger	large	JJR
cord-259603-bh198xgl	701	12	repertoire	repertoire	NN
cord-259603-bh198xgl	701	13	of	of	IN
cord-259603-bh198xgl	701	14	functions	function	NNS
cord-259603-bh198xgl	701	15	for	for	IN
cord-259603-bh198xgl	701	16	preventing	prevent	VBG
cord-259603-bh198xgl	701	17	induction	induction	NN
cord-259603-bh198xgl	701	18	of	of	IN
cord-259603-bh198xgl	701	19	type	type	NN
cord-259603-bh198xgl	702	1	I	-PRON-	PRP
cord-259603-bh198xgl	702	2	interferons	interferon	NNS
cord-259603-bh198xgl	702	3	following	follow	VBG
cord-259603-bh198xgl	702	4	cellular	cellular	JJ
cord-259603-bh198xgl	702	5	sensing	sensing	NN
cord-259603-bh198xgl	702	6	of	of	IN
cord-259603-bh198xgl	702	7	"	"	``
cord-259603-bh198xgl	702	8	nonself	nonself	FW
cord-259603-bh198xgl	702	9	"	"	''
cord-259603-bh198xgl	702	10	RNAs	rna	NNS
cord-259603-bh198xgl	702	11	,	,	,
cord-259603-bh198xgl	702	12	such	such	JJ
cord-259603-bh198xgl	702	13	as	as	IN
cord-259603-bh198xgl	702	14	viral	viral	JJ
cord-259603-bh198xgl	702	15	RNAs	rna	NNS
cord-259603-bh198xgl	702	16	with	with	IN
cord-259603-bh198xgl	702	17	incompletely	incompletely	RB
cord-259603-bh198xgl	702	18	methylated	methylate	VBN
cord-259603-bh198xgl	702	19	5	5	CD
cord-259603-bh198xgl	702	20	0	0	CD
cord-259603-bh198xgl	702	21	cap	cap	NN
cord-259603-bh198xgl	702	22	structures	structure	NNS
cord-259603-bh198xgl	702	23	.	.	.
cord-259603-bh198xgl	703	1	Together	together	RB
cord-259603-bh198xgl	703	2	,	,	,
cord-259603-bh198xgl	703	3	these	these	DT
cord-259603-bh198xgl	703	4	data	datum	NNS
cord-259603-bh198xgl	703	5	established	establish	VBD
cord-259603-bh198xgl	703	6	that	that	IN
cord-259603-bh198xgl	703	7	the	the	DT
cord-259603-bh198xgl	703	8	highly	highly	RB
cord-259603-bh198xgl	703	9	conserved	conserved	JJ
cord-259603-bh198xgl	703	10	nsp16	nsp16	NNS
cord-259603-bh198xgl	703	11	2	2	CD
cord-259603-bh198xgl	703	12	0	0	CD
cord-259603-bh198xgl	703	13	-O	-o	CD
cord-259603-bh198xgl	703	14	-	-	HYPH
cord-259603-bh198xgl	703	15	MTase	MTase	NNP
cord-259603-bh198xgl	703	16	plays	play	VBZ
cord-259603-bh198xgl	703	17	an	an	DT
cord-259603-bh198xgl	703	18	important	important	JJ
cord-259603-bh198xgl	703	19	role	role	NN
cord-259603-bh198xgl	703	20	in	in	IN
cord-259603-bh198xgl	703	21	limiting	limit	VBG
cord-259603-bh198xgl	703	22	the	the	DT
cord-259603-bh198xgl	703	23	detection	detection	NN
cord-259603-bh198xgl	703	24	of	of	IN
cord-259603-bh198xgl	703	25	viral	viral	JJ
cord-259603-bh198xgl	703	26	Fig	fig	NN
cord-259603-bh198xgl	703	27	.	.	.
cord-259603-bh198xgl	704	1	7	7	CD
cord-259603-bh198xgl	705	1	-Cont'd	-Cont'd	.
cord-259603-bh198xgl	706	1	complex	complex	JJ
cord-259603-bh198xgl	706	2	(	(	-LRB-
cord-259603-bh198xgl	706	3	pdb	pdb	NNP
cord-259603-bh198xgl	706	4	2XYV	2xyv	CD
cord-259603-bh198xgl	706	5	)	)	-RRB-
cord-259603-bh198xgl	706	6	.	.	.
cord-259603-bh198xgl	707	1	Nsp10	Nsp10	NNP
cord-259603-bh198xgl	707	2	is	be	VBZ
cord-259603-bh198xgl	707	3	shown	show	VBN
cord-259603-bh198xgl	707	4	in	in	IN
cord-259603-bh198xgl	707	5	ribbon	ribbon	NN
cord-259603-bh198xgl	707	6	representation	representation	NN
cord-259603-bh198xgl	707	7	with	with	IN
cord-259603-bh198xgl	707	8	conserved	conserved	JJ
cord-259603-bh198xgl	707	9	residues	residue	NNS
cord-259603-bh198xgl	707	10	colored	color	VBN
cord-259603-bh198xgl	707	11	in	in	IN
cord-259603-bh198xgl	707	12	dark	dark	NN
cord-259603-bh198xgl	707	13	to	to	IN
cord-259603-bh198xgl	707	14	light	light	JJ
cord-259603-bh198xgl	707	15	blue	blue	JJ
cord-259603-bh198xgl	707	16	according	accord	VBG
cord-259603-bh198xgl	707	17	to	to	IN
cord-259603-bh198xgl	707	18	their	-PRON-	PRP$
cord-259603-bh198xgl	707	19	conservation	conservation	NN
cord-259603-bh198xgl	707	20	among	among	IN
cord-259603-bh198xgl	707	21	CoVs	CoVs	NNP
cord-259603-bh198xgl	707	22	.	.	.
cord-259603-bh198xgl	708	1	Zinc	zinc	NN
cord-259603-bh198xgl	708	2	molecules	molecule	NNS
cord-259603-bh198xgl	708	3	are	be	VBP
cord-259603-bh198xgl	708	4	shown	show	VBN
cord-259603-bh198xgl	708	5	as	as	IN
cord-259603-bh198xgl	708	6	spheres	sphere	NNS
cord-259603-bh198xgl	708	7	and	and	CC
cord-259603-bh198xgl	708	8	zinc	zinc	NN
cord-259603-bh198xgl	708	9	-	-	HYPH
cord-259603-bh198xgl	708	10	coordinating	coordinate	VBG
cord-259603-bh198xgl	708	11	residues	residue	NNS
cord-259603-bh198xgl	708	12	are	be	VBP
cord-259603-bh198xgl	708	13	shown	show	VBN
cord-259603-bh198xgl	708	14	in	in	IN
cord-259603-bh198xgl	708	15	stick	stick	NN
cord-259603-bh198xgl	708	16	representation	representation	NN
cord-259603-bh198xgl	708	17	.	.	.
cord-259603-bh198xgl	709	1	The	the	DT
cord-259603-bh198xgl	709	2	surface	surface	NN
cord-259603-bh198xgl	709	3	of	of	IN
cord-259603-bh198xgl	709	4	nsp16	nsp16	NNS
cord-259603-bh198xgl	709	5	is	be	VBZ
cord-259603-bh198xgl	709	6	colored	color	VBN
cord-259603-bh198xgl	709	7	in	in	IN
cord-259603-bh198xgl	709	8	dark	dark	NN
cord-259603-bh198xgl	709	9	to	to	IN
cord-259603-bh198xgl	709	10	light	light	JJ
cord-259603-bh198xgl	709	11	red	red	JJ
cord-259603-bh198xgl	709	12	according	accord	VBG
cord-259603-bh198xgl	709	13	to	to	IN
cord-259603-bh198xgl	709	14	the	the	DT
cord-259603-bh198xgl	709	15	conservation	conservation	NN
cord-259603-bh198xgl	709	16	of	of	IN
cord-259603-bh198xgl	709	17	the	the	DT
cord-259603-bh198xgl	709	18	respective	respective	JJ
cord-259603-bh198xgl	709	19	residues	residue	NNS
cord-259603-bh198xgl	709	20	among	among	IN
cord-259603-bh198xgl	709	21	coronaviruses	coronaviruse	NNS
cord-259603-bh198xgl	709	22	.	.	.
cord-259603-bh198xgl	710	1	SAH	SAH	NNP
cord-259603-bh198xgl	710	2	is	be	VBZ
cord-259603-bh198xgl	710	3	depicted	depict	VBN
cord-259603-bh198xgl	710	4	in	in	IN
cord-259603-bh198xgl	710	5	a	a	DT
cord-259603-bh198xgl	710	6	stick	stick	NN
cord-259603-bh198xgl	710	7	model	model	NN
cord-259603-bh198xgl	710	8	.	.	.
cord-259603-bh198xgl	711	1	The	the	DT
cord-259603-bh198xgl	711	2	figure	figure	NN
cord-259603-bh198xgl	711	3	was	be	VBD
cord-259603-bh198xgl	711	4	generated	generate	VBN
cord-259603-bh198xgl	711	5	using	use	VBG
cord-259603-bh198xgl	711	6	UCSF	UCSF	NNP
cord-259603-bh198xgl	711	7	Chimera	Chimera	NNP
cord-259603-bh198xgl	711	8	(	(	-LRB-
cord-259603-bh198xgl	711	9	Pettersen	Pettersen	NNP
cord-259603-bh198xgl	711	10	et	et	NNP
cord-259603-bh198xgl	711	11	al	al	NNP
cord-259603-bh198xgl	711	12	.	.	NNP
cord-259603-bh198xgl	711	13	,	,	,
cord-259603-bh198xgl	711	14	2004	2004	CD
cord-259603-bh198xgl	711	15	)	)	-RRB-
cord-259603-bh198xgl	711	16	.	.	.
cord-259603-bh198xgl	712	1	The	the	DT
cord-259603-bh198xgl	712	2	degree	degree	NN
cord-259603-bh198xgl	712	3	of	of	IN
cord-259603-bh198xgl	712	4	conservation	conservation	NN
cord-259603-bh198xgl	712	5	of	of	IN
cord-259603-bh198xgl	712	6	specific	specific	JJ
cord-259603-bh198xgl	712	7	residues	residue	NNS
cord-259603-bh198xgl	712	8	was	be	VBD
cord-259603-bh198xgl	712	9	determined	determine	VBN
cord-259603-bh198xgl	712	10	using	use	VBG
cord-259603-bh198xgl	712	11	an	an	DT
cord-259603-bh198xgl	712	12	alignment	alignment	NN
cord-259603-bh198xgl	712	13	of	of	IN
cord-259603-bh198xgl	712	14	nsp10	nsp10	NNS
cord-259603-bh198xgl	712	15	and	and	CC
cord-259603-bh198xgl	712	16	nsp16	nsp16	NNS
cord-259603-bh198xgl	712	17	sequences	sequence	NNS
cord-259603-bh198xgl	712	18	of	of	IN
cord-259603-bh198xgl	712	19	eight	eight	CD
cord-259603-bh198xgl	712	20	coronaviruses	coronaviruse	NNS
cord-259603-bh198xgl	712	21	(	(	-LRB-
cord-259603-bh198xgl	712	22	see	see	VB
cord-259603-bh198xgl	712	23	Fig	Fig	NNP
cord-259603-bh198xgl	712	24	.	.	.
cord-259603-bh198xgl	712	25	6	6	CD
cord-259603-bh198xgl	712	26	)	)	-RRB-
cord-259603-bh198xgl	712	27	.	.	.
cord-259603-bh198xgl	713	1	RNA	RNA	NNP
cord-259603-bh198xgl	713	2	by	by	IN
cord-259603-bh198xgl	713	3	the	the	DT
cord-259603-bh198xgl	713	4	host	host	NN
cord-259603-bh198xgl	713	5	's	's	POS
cord-259603-bh198xgl	713	6	antiviral	antiviral	JJ
cord-259603-bh198xgl	713	7	sensors	sensor	NNS
cord-259603-bh198xgl	713	8	,	,	,
cord-259603-bh198xgl	713	9	but	but	CC
cord-259603-bh198xgl	713	10	that	that	IN
cord-259603-bh198xgl	713	11	the	the	DT
cord-259603-bh198xgl	713	12	specific	specific	JJ
cord-259603-bh198xgl	713	13	role	role	NN
cord-259603-bh198xgl	713	14	of	of	IN
cord-259603-bh198xgl	713	15	this	this	DT
cord-259603-bh198xgl	713	16	activity	activity	NN
cord-259603-bh198xgl	713	17	in	in	IN
cord-259603-bh198xgl	713	18	escaping	escape	VBG
cord-259603-bh198xgl	713	19	host	host	NN
cord-259603-bh198xgl	713	20	innate	innate	JJ
cord-259603-bh198xgl	713	21	immune	immune	JJ
cord-259603-bh198xgl	713	22	responses	response	NNS
cord-259603-bh198xgl	713	23	may	may	MD
cord-259603-bh198xgl	713	24	differ	differ	VB
cord-259603-bh198xgl	713	25	to	to	IN
cord-259603-bh198xgl	713	26	some	some	DT
cord-259603-bh198xgl	713	27	extent	extent	NN
cord-259603-bh198xgl	713	28	among	among	IN
cord-259603-bh198xgl	713	29	CoVs	CoVs	NNP
cord-259603-bh198xgl	713	30	.	.	.
cord-259603-bh198xgl	714	1	The	the	DT
cord-259603-bh198xgl	714	2	mechanism	mechanism	NN
cord-259603-bh198xgl	714	3	underlying	underlie	VBG
cord-259603-bh198xgl	714	4	the	the	DT
cord-259603-bh198xgl	714	5	induction	induction	NN
cord-259603-bh198xgl	714	6	of	of	IN
cord-259603-bh198xgl	714	7	the	the	DT
cord-259603-bh198xgl	714	8	antiviral	antiviral	JJ
cord-259603-bh198xgl	714	9	immune	immune	JJ
cord-259603-bh198xgl	714	10	response	response	NN
cord-259603-bh198xgl	714	11	following	follow	VBG
cord-259603-bh198xgl	714	12	infection	infection	NN
cord-259603-bh198xgl	714	13	with	with	IN
cord-259603-bh198xgl	714	14	2	2	CD
cord-259603-bh198xgl	714	15	0	0	CD
cord-259603-bh198xgl	714	16	-O	-o	CD
cord-259603-bh198xgl	714	17	-	-	HYPH
cord-259603-bh198xgl	714	18	MTase	mtase	JJ
cord-259603-bh198xgl	714	19	knockout	knockout	NN
cord-259603-bh198xgl	714	20	mutants	mutant	NNS
cord-259603-bh198xgl	714	21	was	be	VBD
cord-259603-bh198xgl	714	22	studied	study	VBN
cord-259603-bh198xgl	714	23	using	use	VBG
cord-259603-bh198xgl	714	24	specific	specific	JJ
cord-259603-bh198xgl	714	25	knockout	knockout	NN
cord-259603-bh198xgl	714	26	mice	mouse	NNS
cord-259603-bh198xgl	714	27	in	in	IN
cord-259603-bh198xgl	714	28	which	which	WDT
cord-259603-bh198xgl	714	29	viral	viral	JJ
cord-259603-bh198xgl	714	30	replication	replication	NN
cord-259603-bh198xgl	714	31	was	be	VBD
cord-259603-bh198xgl	714	32	found	find	VBN
cord-259603-bh198xgl	714	33	to	to	TO
cord-259603-bh198xgl	714	34	be	be	VB
cord-259603-bh198xgl	714	35	restored	restore	VBN
cord-259603-bh198xgl	714	36	.	.	.
cord-259603-bh198xgl	715	1	The	the	DT
cord-259603-bh198xgl	715	2	absence	absence	NN
cord-259603-bh198xgl	715	3	of	of	IN
cord-259603-bh198xgl	715	4	Mda5	Mda5	NNP
cord-259603-bh198xgl	715	5	,	,	,
cord-259603-bh198xgl	715	6	a	a	DT
cord-259603-bh198xgl	715	7	cap-0	cap-0	NN
cord-259603-bh198xgl	715	8	sensor	sensor	NN
cord-259603-bh198xgl	715	9	,	,	,
cord-259603-bh198xgl	715	10	restored	restore	VBD
cord-259603-bh198xgl	715	11	MHV	MHV	NNP
cord-259603-bh198xgl	715	12	replication	replication	NN
cord-259603-bh198xgl	715	13	,	,	,
cord-259603-bh198xgl	715	14	whereas	whereas	IN
cord-259603-bh198xgl	715	15	the	the	DT
cord-259603-bh198xgl	715	16	nuclear	nuclear	JJ
cord-259603-bh198xgl	715	17	translocation	translocation	NN
cord-259603-bh198xgl	715	18	of	of	IN
cord-259603-bh198xgl	715	19	IRF3	IRF3	NNP
cord-259603-bh198xgl	715	20	and	and	CC
cord-259603-bh198xgl	715	21	interferon	interferon	NN
cord-259603-bh198xgl	715	22	induction	induction	NN
cord-259603-bh198xgl	715	23	were	be	VBD
cord-259603-bh198xgl	715	24	reduced	reduce	VBN
cord-259603-bh198xgl	715	25	(	(	-LRB-
cord-259603-bh198xgl	715	26	Z€	Z€	NNP
cord-259603-bh198xgl	715	27	ust	ust	NNP
cord-259603-bh198xgl	715	28	et	et	NNP
cord-259603-bh198xgl	715	29	al	al	NNP
cord-259603-bh198xgl	715	30	.	.	NNP
cord-259603-bh198xgl	715	31	,	,	,
cord-259603-bh198xgl	715	32	2011	2011	CD
cord-259603-bh198xgl	715	33	)	)	-RRB-
cord-259603-bh198xgl	715	34	.	.	.
cord-259603-bh198xgl	716	1	This	this	DT
cord-259603-bh198xgl	716	2	suggested	suggest	VBD
cord-259603-bh198xgl	716	3	Mda5	Mda5	NNP
cord-259603-bh198xgl	716	4	to	to	TO
cord-259603-bh198xgl	716	5	function	function	VB
cord-259603-bh198xgl	716	6	in	in	IN
cord-259603-bh198xgl	716	7	the	the	DT
cord-259603-bh198xgl	716	8	primary	primary	JJ
cord-259603-bh198xgl	716	9	recognition	recognition	NN
cord-259603-bh198xgl	716	10	of	of	IN
cord-259603-bh198xgl	716	11	the	the	DT
cord-259603-bh198xgl	716	12	RNA	RNA	NNP
cord-259603-bh198xgl	716	13	produced	produce	VBN
cord-259603-bh198xgl	716	14	by	by	IN
cord-259603-bh198xgl	716	15	CoV	CoV	NNP
cord-259603-bh198xgl	716	16	2	2	CD
cord-259603-bh198xgl	716	17	0	0	CD
cord-259603-bh198xgl	716	18	-O	-O	:
cord-259603-bh198xgl	716	19	-	-	HYPH
cord-259603-bh198xgl	716	20	MTase	mtase	JJ
cord-259603-bh198xgl	716	21	mutants	mutant	NNS
cord-259603-bh198xgl	716	22	and	and	CC
cord-259603-bh198xgl	716	23	to	to	TO
cord-259603-bh198xgl	716	24	initiate	initiate	VB
cord-259603-bh198xgl	716	25	the	the	DT
cord-259603-bh198xgl	716	26	ISG	ISG	NNP
cord-259603-bh198xgl	716	27	cascade	cascade	NN
cord-259603-bh198xgl	716	28	that	that	WDT
cord-259603-bh198xgl	716	29	restricts	restrict	VBZ
cord-259603-bh198xgl	716	30	viral	viral	JJ
cord-259603-bh198xgl	716	31	replication	replication	NN
cord-259603-bh198xgl	716	32	.	.	.
cord-259603-bh198xgl	717	1	Among	among	IN
cord-259603-bh198xgl	717	2	the	the	DT
cord-259603-bh198xgl	717	3	ISG	ISG	NNP
cord-259603-bh198xgl	717	4	products	product	NNS
cord-259603-bh198xgl	717	5	,	,	,
cord-259603-bh198xgl	717	6	the	the	DT
cord-259603-bh198xgl	717	7	IFIT	IFIT	NNP
cord-259603-bh198xgl	717	8	family	family	NN
cord-259603-bh198xgl	717	9	of	of	IN
cord-259603-bh198xgl	717	10	proteins	protein	NNS
cord-259603-bh198xgl	717	11	was	be	VBD
cord-259603-bh198xgl	717	12	shown	show	VBN
cord-259603-bh198xgl	717	13	to	to	TO
cord-259603-bh198xgl	717	14	be	be	VB
cord-259603-bh198xgl	717	15	critically	critically	RB
cord-259603-bh198xgl	717	16	involved	involve	VBN
cord-259603-bh198xgl	717	17	in	in	IN
cord-259603-bh198xgl	717	18	reducing	reduce	VBG
cord-259603-bh198xgl	717	19	the	the	DT
cord-259603-bh198xgl	717	20	replication	replication	NN
cord-259603-bh198xgl	717	21	of	of	IN
cord-259603-bh198xgl	717	22	CoV	CoV	NNP
cord-259603-bh198xgl	717	23	nsp16	nsp16	NNS
cord-259603-bh198xgl	717	24	mutants	mutant	NNS
cord-259603-bh198xgl	717	25	.	.	.
cord-259603-bh198xgl	718	1	The	the	DT
cord-259603-bh198xgl	718	2	replication	replication	NN
cord-259603-bh198xgl	718	3	of	of	IN
cord-259603-bh198xgl	718	4	MHV	MHV	NNP
cord-259603-bh198xgl	718	5	and	and	CC
cord-259603-bh198xgl	718	6	HCoV-229E	HCoV-229E	NNP
cord-259603-bh198xgl	718	7	nsp16	nsp16	NNS
cord-259603-bh198xgl	718	8	mutants	mutant	NNS
cord-259603-bh198xgl	718	9	and	and	CC
cord-259603-bh198xgl	718	10	wild	wild	JJ
cord-259603-bh198xgl	718	11	-	-	HYPH
cord-259603-bh198xgl	718	12	type	type	NN
cord-259603-bh198xgl	718	13	controls	control	NNS
cord-259603-bh198xgl	718	14	was	be	VBD
cord-259603-bh198xgl	718	15	similar	similar	JJ
cord-259603-bh198xgl	718	16	in	in	IN
cord-259603-bh198xgl	718	17	IFIT1À	IFIT1À	NNP
cord-259603-bh198xgl	718	18	/	/	SYM
cord-259603-bh198xgl	718	19	À	à	NN
cord-259603-bh198xgl	718	20	knockout	knockout	NN
cord-259603-bh198xgl	718	21	mice	mouse	NNS
cord-259603-bh198xgl	719	1	(	(	-LRB-
cord-259603-bh198xgl	719	2	Habjan	Habjan	NNP
cord-259603-bh198xgl	719	3	et	et	NNP
cord-259603-bh198xgl	719	4	al	al	NNP
cord-259603-bh198xgl	719	5	.	.	.
cord-259603-bh198xgl	720	1	,	,	,
cord-259603-bh198xgl	720	2	2013	2013	CD
cord-259603-bh198xgl	720	3	;	;	:
cord-259603-bh198xgl	720	4	Z€	Z€	NNP
cord-259603-bh198xgl	720	5	ust	ust	NNP
cord-259603-bh198xgl	720	6	et	et	NNP
cord-259603-bh198xgl	720	7	al	al	NNP
cord-259603-bh198xgl	720	8	.	.	NNP
cord-259603-bh198xgl	720	9	,	,	,
cord-259603-bh198xgl	720	10	2011	2011	CD
cord-259603-bh198xgl	720	11	)	)	-RRB-
cord-259603-bh198xgl	720	12	.	.	.
cord-259603-bh198xgl	721	1	Likewise	likewise	RB
cord-259603-bh198xgl	721	2	,	,	,
cord-259603-bh198xgl	721	3	replication	replication	NN
cord-259603-bh198xgl	721	4	of	of	IN
cord-259603-bh198xgl	721	5	a	a	DT
cord-259603-bh198xgl	721	6	SARS	SARS	NNP
cord-259603-bh198xgl	721	7	-	-	HYPH
cord-259603-bh198xgl	721	8	CoV	CoV	NNP
cord-259603-bh198xgl	721	9	Δnsp16	Δnsp16	NNS
cord-259603-bh198xgl	721	10	mutant	mutant	NN
cord-259603-bh198xgl	721	11	was	be	VBD
cord-259603-bh198xgl	721	12	increased	increase	VBN
cord-259603-bh198xgl	721	13	in	in	IN
cord-259603-bh198xgl	721	14	both	both	DT
cord-259603-bh198xgl	721	15	IFIT1	ifit1	JJ
cord-259603-bh198xgl	721	16	and	and	CC
cord-259603-bh198xgl	721	17	IFIT2	IFIT2	NNP
cord-259603-bh198xgl	721	18	knockdown	knockdown	NNP
cord-259603-bh198xgl	721	19	mice	mouse	NNS
cord-259603-bh198xgl	722	1	(	(	-LRB-
cord-259603-bh198xgl	722	2	Menachery	Menachery	NNP
cord-259603-bh198xgl	722	3	et	et	NNP
cord-259603-bh198xgl	722	4	al	al	NNP
cord-259603-bh198xgl	722	5	.	.	.
cord-259603-bh198xgl	723	1	,	,	,
cord-259603-bh198xgl	723	2	2014	2014	CD
cord-259603-bh198xgl	723	3	)	)	-RRB-
cord-259603-bh198xgl	723	4	,	,	,
cord-259603-bh198xgl	723	5	suggesting	suggest	VBG
cord-259603-bh198xgl	723	6	that	that	IN
cord-259603-bh198xgl	723	7	IFIT	IFIT	NNP
cord-259603-bh198xgl	723	8	family	family	NN
cord-259603-bh198xgl	723	9	proteins	protein	NNS
cord-259603-bh198xgl	723	10	mediate	mediate	VBP
cord-259603-bh198xgl	723	11	the	the	DT
cord-259603-bh198xgl	723	12	primary	primary	JJ
cord-259603-bh198xgl	723	13	attenuation	attenuation	NN
cord-259603-bh198xgl	723	14	of	of	IN
cord-259603-bh198xgl	723	15	SARS	SARS	NNP
cord-259603-bh198xgl	723	16	-	-	HYPH
cord-259603-bh198xgl	723	17	CoV	CoV	NNP
cord-259603-bh198xgl	723	18	2	2	CD
cord-259603-bh198xgl	723	19	0	0	CD
cord-259603-bh198xgl	723	20	-O	-o	CD
cord-259603-bh198xgl	723	21	-	-	HYPH
cord-259603-bh198xgl	723	22	MTase	mtase	JJ
cord-259603-bh198xgl	723	23	knockout	knockout	NN
cord-259603-bh198xgl	723	24	mutants	mutant	NNS
cord-259603-bh198xgl	723	25	.	.	.
cord-259603-bh198xgl	724	1	The	the	DT
cord-259603-bh198xgl	724	2	earlier	early	JJR
cord-259603-bh198xgl	724	3	results	result	NNS
cord-259603-bh198xgl	724	4	indicate	indicate	VBP
cord-259603-bh198xgl	724	5	that	that	IN
cord-259603-bh198xgl	724	6	the	the	DT
cord-259603-bh198xgl	724	7	nsp16	nsp16	NNS
cord-259603-bh198xgl	724	8	2	2	CD
cord-259603-bh198xgl	724	9	0	0	CD
cord-259603-bh198xgl	724	10	-O	-O	:
cord-259603-bh198xgl	724	11	-	-	HYPH
cord-259603-bh198xgl	724	12	MTase	MTase	NNP
cord-259603-bh198xgl	724	13	constitutes	constitute	VBZ
cord-259603-bh198xgl	724	14	a	a	DT
cord-259603-bh198xgl	724	15	new	new	JJ
cord-259603-bh198xgl	724	16	and	and	CC
cord-259603-bh198xgl	724	17	attractive	attractive	JJ
cord-259603-bh198xgl	724	18	target	target	NN
cord-259603-bh198xgl	724	19	for	for	IN
cord-259603-bh198xgl	724	20	the	the	DT
cord-259603-bh198xgl	724	21	development	development	NN
cord-259603-bh198xgl	724	22	of	of	IN
cord-259603-bh198xgl	724	23	antiviral	antiviral	JJ
cord-259603-bh198xgl	724	24	drugs	drug	NNS
cord-259603-bh198xgl	724	25	against	against	IN
cord-259603-bh198xgl	724	26	SARS	SARS	NNP
cord-259603-bh198xgl	724	27	-	-	HYPH
cord-259603-bh198xgl	724	28	CoV	CoV	NNP
cord-259603-bh198xgl	724	29	and	and	CC
cord-259603-bh198xgl	724	30	HCoV-229E	HCoV-229E	NNP
cord-259603-bh198xgl	724	31	,	,	,
cord-259603-bh198xgl	724	32	as	as	RB
cord-259603-bh198xgl	724	33	well	well	RB
cord-259603-bh198xgl	724	34	as	as	IN
cord-259603-bh198xgl	724	35	newly	newly	RB
cord-259603-bh198xgl	724	36	emerging	emerge	VBG
cord-259603-bh198xgl	724	37	CoVs	CoVs	NNP
cord-259603-bh198xgl	724	38	like	like	IN
cord-259603-bh198xgl	724	39	MERS	MERS	NNP
cord-259603-bh198xgl	724	40	-	-	HYPH
cord-259603-bh198xgl	724	41	CoV	CoV	NNP
cord-259603-bh198xgl	724	42	and	and	CC
cord-259603-bh198xgl	724	43	porcine	porcine	JJ
cord-259603-bh198xgl	724	44	epidemic	epidemic	NN
cord-259603-bh198xgl	724	45	diarrhea	diarrhea	NN
cord-259603-bh198xgl	724	46	virus	virus	NN
cord-259603-bh198xgl	724	47	(	(	-LRB-
cord-259603-bh198xgl	724	48	PEDV	PEDV	NNP
cord-259603-bh198xgl	724	49	)	)	-RRB-
cord-259603-bh198xgl	724	50	.	.	.
cord-259603-bh198xgl	725	1	For	for	IN
cord-259603-bh198xgl	725	2	example	example	NN
cord-259603-bh198xgl	725	3	,	,	,
cord-259603-bh198xgl	725	4	the	the	DT
cord-259603-bh198xgl	725	5	nsp10-nsp16	nsp10-nsp16	NNP
cord-259603-bh198xgl	725	6	interface	interface	NN
cord-259603-bh198xgl	725	7	may	may	MD
cord-259603-bh198xgl	725	8	be	be	VB
cord-259603-bh198xgl	725	9	targeted	target	VBN
cord-259603-bh198xgl	725	10	to	to	TO
cord-259603-bh198xgl	725	11	limit	limit	VB
cord-259603-bh198xgl	725	12	viral	viral	JJ
cord-259603-bh198xgl	725	13	2	2	CD
cord-259603-bh198xgl	725	14	0	0	CD
cord-259603-bh198xgl	725	15	-O	-o	CD
cord-259603-bh198xgl	725	16	-	-	HYPH
cord-259603-bh198xgl	725	17	MTase	mtase	JJ
cord-259603-bh198xgl	725	18	activity	activity	NN
cord-259603-bh198xgl	725	19	and	and	CC
cord-259603-bh198xgl	725	20	thus	thus	RB
cord-259603-bh198xgl	725	21	restore	restore	VB
cord-259603-bh198xgl	725	22	the	the	DT
cord-259603-bh198xgl	725	23	antiviral	antiviral	JJ
cord-259603-bh198xgl	725	24	responses	response	NNS
cord-259603-bh198xgl	725	25	mediated	mediate	VBN
cord-259603-bh198xgl	725	26	by	by	IN
cord-259603-bh198xgl	725	27	Mda5	Mda5	NNP
cord-259603-bh198xgl	725	28	and	and	CC
cord-259603-bh198xgl	725	29	IFIT1	IFIT1	NNP
cord-259603-bh198xgl	726	1	(	(	-LRB-
cord-259603-bh198xgl	726	2	Menachery	Menachery	NNP
cord-259603-bh198xgl	726	3	and	and	CC
cord-259603-bh198xgl	726	4	Baric	Baric	NNP
cord-259603-bh198xgl	726	5	,	,	,
cord-259603-bh198xgl	726	6	2013	2013	CD
cord-259603-bh198xgl	726	7	)	)	-RRB-
cord-259603-bh198xgl	726	8	.	.	.
cord-259603-bh198xgl	727	1	Interestingly	interestingly	RB
cord-259603-bh198xgl	727	2	,	,	,
cord-259603-bh198xgl	727	3	the	the	DT
cord-259603-bh198xgl	727	4	nsp10	nsp10	JJ
cord-259603-bh198xgl	727	5	residues	residue	NNS
cord-259603-bh198xgl	727	6	involved	involve	VBN
cord-259603-bh198xgl	727	7	in	in	IN
cord-259603-bh198xgl	727	8	the	the	DT
cord-259603-bh198xgl	727	9	nsp10	nsp10	NNPS
cord-259603-bh198xgl	727	10	/	/	SYM
cord-259603-bh198xgl	727	11	nsp16	nsp16	NNS
cord-259603-bh198xgl	727	12	interaction	interaction	NN
cord-259603-bh198xgl	727	13	are	be	VBP
cord-259603-bh198xgl	727	14	quite	quite	RB
cord-259603-bh198xgl	727	15	conserved	conserve	VBN
cord-259603-bh198xgl	727	16	within	within	IN
cord-259603-bh198xgl	727	17	the	the	DT
cord-259603-bh198xgl	727	18	CoV	cov	NN
cord-259603-bh198xgl	727	19	family	family	NN
cord-259603-bh198xgl	727	20	and	and	CC
cord-259603-bh198xgl	727	21	it	-PRON-	PRP
cord-259603-bh198xgl	727	22	was	be	VBD
cord-259603-bh198xgl	727	23	recently	recently	RB
cord-259603-bh198xgl	727	24	demonstrated	demonstrate	VBN
cord-259603-bh198xgl	727	25	that	that	IN
cord-259603-bh198xgl	727	26	nsp10	nsp10	JJR
cord-259603-bh198xgl	727	27	of	of	IN
cord-259603-bh198xgl	727	28	different	different	JJ
cord-259603-bh198xgl	727	29	CoVs	CoVs	NNP
cord-259603-bh198xgl	727	30	(	(	-LRB-
cord-259603-bh198xgl	727	31	FCoV	FCoV	NNP
cord-259603-bh198xgl	727	32	,	,	,
cord-259603-bh198xgl	727	33	MHV	MHV	NNP
cord-259603-bh198xgl	727	34	,	,	,
cord-259603-bh198xgl	727	35	SARS	SARS	NNP
cord-259603-bh198xgl	727	36	-	-	HYPH
cord-259603-bh198xgl	727	37	CoV	CoV	NNP
cord-259603-bh198xgl	727	38	,	,	,
cord-259603-bh198xgl	727	39	MERS	MERS	NNP
cord-259603-bh198xgl	727	40	-	-	HYPH
cord-259603-bh198xgl	727	41	CoV	CoV	NNP
cord-259603-bh198xgl	727	42	)	)	-RRB-
cord-259603-bh198xgl	727	43	is	be	VBZ
cord-259603-bh198xgl	727	44	functionally	functionally	RB
cord-259603-bh198xgl	727	45	interchangeable	interchangeable	JJ
cord-259603-bh198xgl	727	46	in	in	IN
cord-259603-bh198xgl	727	47	the	the	DT
cord-259603-bh198xgl	727	48	stimulation	stimulation	NN
cord-259603-bh198xgl	727	49	of	of	IN
cord-259603-bh198xgl	727	50	nsp16	nsp16	NNS
cord-259603-bh198xgl	727	51	2	2	CD
cord-259603-bh198xgl	727	52	0	0	CD
cord-259603-bh198xgl	727	53	-O	-o	CD
cord-259603-bh198xgl	727	54	-	-	HYPH
cord-259603-bh198xgl	727	55	MTase	mtase	JJ
cord-259603-bh198xgl	727	56	activity	activity	NN
cord-259603-bh198xgl	727	57	.	.	.
cord-259603-bh198xgl	728	1	Thus	thus	RB
cord-259603-bh198xgl	728	2	,	,	,
cord-259603-bh198xgl	728	3	molecules	molecule	NNS
cord-259603-bh198xgl	728	4	or	or	CC
cord-259603-bh198xgl	728	5	peptides	peptide	NNS
cord-259603-bh198xgl	728	6	blocking	block	VBG
cord-259603-bh198xgl	728	7	this	this	DT
cord-259603-bh198xgl	728	8	interface	interface	NN
cord-259603-bh198xgl	728	9	may	may	MD
cord-259603-bh198xgl	728	10	have	have	VB
cord-259603-bh198xgl	728	11	broad	broad	JJ
cord-259603-bh198xgl	728	12	-	-	HYPH
cord-259603-bh198xgl	728	13	spectrum	spectrum	NN
cord-259603-bh198xgl	728	14	anti	anti	JJ
cord-259603-bh198xgl	728	15	-	-	JJ
cord-259603-bh198xgl	728	16	CoV	cov	JJ
cord-259603-bh198xgl	728	17	effects	effect	NNS
cord-259603-bh198xgl	728	18	,	,	,
cord-259603-bh198xgl	728	19	a	a	DT
cord-259603-bh198xgl	728	20	concept	concept	NN
cord-259603-bh198xgl	728	21	that	that	WDT
cord-259603-bh198xgl	728	22	was	be	VBD
cord-259603-bh198xgl	728	23	explored	explore	VBN
cord-259603-bh198xgl	728	24	and	and	CC
cord-259603-bh198xgl	728	25	supported	support	VBN
cord-259603-bh198xgl	728	26	using	use	VBG
cord-259603-bh198xgl	728	27	synthetic	synthetic	JJ
cord-259603-bh198xgl	728	28	peptides	peptide	NNS
cord-259603-bh198xgl	728	29	that	that	WDT
cord-259603-bh198xgl	728	30	mimic	mimic	VBP
cord-259603-bh198xgl	728	31	the	the	DT
cord-259603-bh198xgl	728	32	nsp10	nsp10	NNP
cord-259603-bh198xgl	728	33	interface	interface	NN
cord-259603-bh198xgl	728	34	and	and	CC
cord-259603-bh198xgl	728	35	suppress	suppress	VBP
cord-259603-bh198xgl	728	36	nsp16	nsp16	NNS
cord-259603-bh198xgl	728	37	2	2	CD
cord-259603-bh198xgl	728	38	0	0	CD
cord-259603-bh198xgl	728	39	-O	-o	CD
cord-259603-bh198xgl	728	40	-	-	HYPH
cord-259603-bh198xgl	728	41	MTase	mtase	JJ
cord-259603-bh198xgl	728	42	activity	activity	NN
cord-259603-bh198xgl	728	43	in	in	IN
cord-259603-bh198xgl	728	44	vitro	vitro	FW
cord-259603-bh198xgl	728	45	(	(	-LRB-
cord-259603-bh198xgl	729	1	Ke	Ke	NNP
cord-259603-bh198xgl	729	2	et	et	NNP
cord-259603-bh198xgl	729	3	al	al	NNP
cord-259603-bh198xgl	729	4	.	.	NNP
cord-259603-bh198xgl	729	5	,	,	,
cord-259603-bh198xgl	729	6	2012	2012	CD
cord-259603-bh198xgl	729	7	;	;	:
cord-259603-bh198xgl	729	8	Wang	Wang	NNP
cord-259603-bh198xgl	729	9	et	et	NNP
cord-259603-bh198xgl	729	10	al	al	NNP
cord-259603-bh198xgl	729	11	.	.	NNP
cord-259603-bh198xgl	729	12	,	,	,
cord-259603-bh198xgl	729	13	2015	2015	CD
cord-259603-bh198xgl	729	14	)	)	-RRB-
cord-259603-bh198xgl	729	15	.	.	.
cord-259603-bh198xgl	730	1	The	the	DT
cord-259603-bh198xgl	730	2	antiviral	antiviral	JJ
cord-259603-bh198xgl	730	3	effect	effect	NN
cord-259603-bh198xgl	730	4	of	of	IN
cord-259603-bh198xgl	730	5	the	the	DT
cord-259603-bh198xgl	730	6	MHV	MHV	NNP
cord-259603-bh198xgl	730	7	TP29	TP29	NNP
cord-259603-bh198xgl	730	8	peptide	peptide	NN
cord-259603-bh198xgl	730	9	,	,	,
cord-259603-bh198xgl	730	10	for	for	IN
cord-259603-bh198xgl	730	11	example	example	NN
cord-259603-bh198xgl	730	12	,	,	,
cord-259603-bh198xgl	730	13	was	be	VBD
cord-259603-bh198xgl	730	14	first	first	RB
cord-259603-bh198xgl	730	15	demonstrated	demonstrate	VBN
cord-259603-bh198xgl	730	16	in	in	IN
cord-259603-bh198xgl	730	17	MHV	MHV	NNP
cord-259603-bh198xgl	730	18	-	-	HYPH
cord-259603-bh198xgl	730	19	infected	infect	VBN
cord-259603-bh198xgl	730	20	cells	cell	NNS
cord-259603-bh198xgl	730	21	and	and	CC
cord-259603-bh198xgl	730	22	was	be	VBD
cord-259603-bh198xgl	730	23	subsequently	subsequently	RB
cord-259603-bh198xgl	730	24	confirmed	confirm	VBN
cord-259603-bh198xgl	730	25	to	to	TO
cord-259603-bh198xgl	730	26	limit	limit	VB
cord-259603-bh198xgl	730	27	MHV	MHV	NNP
cord-259603-bh198xgl	730	28	replication	replication	NN
cord-259603-bh198xgl	730	29	in	in	IN
cord-259603-bh198xgl	730	30	mice	mouse	NNS
cord-259603-bh198xgl	730	31	and	and	CC
cord-259603-bh198xgl	730	32	to	to	TO
cord-259603-bh198xgl	730	33	enhance	enhance	VB
cord-259603-bh198xgl	730	34	the	the	DT
cord-259603-bh198xgl	730	35	type	type	NN
cord-259603-bh198xgl	730	36	I	-PRON-	PRP
cord-259603-bh198xgl	730	37	interferon	interferon	VBD
cord-259603-bh198xgl	730	38	response	response	NN
cord-259603-bh198xgl	730	39	.	.	.
cord-259603-bh198xgl	731	1	The	the	DT
cord-259603-bh198xgl	731	2	same	same	JJ
cord-259603-bh198xgl	731	3	peptide	peptide	NN
cord-259603-bh198xgl	731	4	was	be	VBD
cord-259603-bh198xgl	731	5	also	also	RB
cord-259603-bh198xgl	731	6	effective	effective	JJ
cord-259603-bh198xgl	731	7	in	in	IN
cord-259603-bh198xgl	731	8	blocking	block	VBG
cord-259603-bh198xgl	731	9	the	the	DT
cord-259603-bh198xgl	731	10	replication	replication	NN
cord-259603-bh198xgl	731	11	of	of	IN
cord-259603-bh198xgl	731	12	a	a	DT
cord-259603-bh198xgl	731	13	SARS	SARS	NNP
cord-259603-bh198xgl	731	14	-	-	HYPH
cord-259603-bh198xgl	731	15	CoV	CoV	NNP
cord-259603-bh198xgl	731	16	replicon	replicon	NN
cord-259603-bh198xgl	731	17	.	.	.
cord-259603-bh198xgl	732	1	The	the	DT
cord-259603-bh198xgl	732	2	CoV	cov	NN
cord-259603-bh198xgl	732	3	ExoN	ExoN	NNP
cord-259603-bh198xgl	732	4	domain	domain	NN
cord-259603-bh198xgl	732	5	was	be	VBD
cord-259603-bh198xgl	732	6	identified	identify	VBN
cord-259603-bh198xgl	732	7	on	on	IN
cord-259603-bh198xgl	732	8	the	the	DT
cord-259603-bh198xgl	732	9	basis	basis	NN
cord-259603-bh198xgl	732	10	of	of	IN
cord-259603-bh198xgl	732	11	comparative	comparative	JJ
cord-259603-bh198xgl	732	12	sequence	sequence	NN
cord-259603-bh198xgl	732	13	analyses	analysis	NNS
cord-259603-bh198xgl	732	14	(	(	-LRB-
cord-259603-bh198xgl	732	15	Snijder	Snijder	NNP
cord-259603-bh198xgl	732	16	et	et	NNP
cord-259603-bh198xgl	732	17	al	al	NNP
cord-259603-bh198xgl	732	18	.	.	NNP
cord-259603-bh198xgl	732	19	,	,	,
cord-259603-bh198xgl	732	20	2003	2003	CD
cord-259603-bh198xgl	732	21	)	)	-RRB-
cord-259603-bh198xgl	732	22	that	that	WDT
cord-259603-bh198xgl	732	23	suggested	suggest	VBD
cord-259603-bh198xgl	732	24	a	a	DT
cord-259603-bh198xgl	732	25	distant	distant	JJ
cord-259603-bh198xgl	732	26	relationship	relationship	NN
cord-259603-bh198xgl	732	27	of	of	IN
cord-259603-bh198xgl	732	28	the	the	DT
cord-259603-bh198xgl	732	29	nsp14	nsp14	NNP
cord-259603-bh198xgl	732	30	N	n	CD
cord-259603-bh198xgl	732	31	-	-	HYPH
cord-259603-bh198xgl	732	32	terminal	terminal	NN
cord-259603-bh198xgl	732	33	domain	domain	NN
cord-259603-bh198xgl	732	34	(	(	-LRB-
cord-259603-bh198xgl	732	35	and	and	CC
cord-259603-bh198xgl	732	36	equivalent	equivalent	JJ
cord-259603-bh198xgl	732	37	polyprotein	polyprotein	JJ
cord-259603-bh198xgl	732	38	regions	region	NNS
cord-259603-bh198xgl	732	39	of	of	IN
cord-259603-bh198xgl	732	40	other	other	JJ
cord-259603-bh198xgl	732	41	nidoviruses	nidoviruse	NNS
cord-259603-bh198xgl	732	42	)	)	-RRB-
cord-259603-bh198xgl	732	43	with	with	IN
cord-259603-bh198xgl	732	44	cellular	cellular	JJ
cord-259603-bh198xgl	732	45	DEDD	DEDD	NNP
cord-259603-bh198xgl	732	46	exonucleases	exonuclease	NNS
cord-259603-bh198xgl	732	47	,	,	,
cord-259603-bh198xgl	732	48	a	a	DT
cord-259603-bh198xgl	732	49	large	large	JJ
cord-259603-bh198xgl	732	50	protein	protein	NN
cord-259603-bh198xgl	732	51	superfamily	superfamily	NN
cord-259603-bh198xgl	732	52	containing	contain	VBG
cord-259603-bh198xgl	732	53	RNA	RNA	NNP
cord-259603-bh198xgl	732	54	and	and	CC
cord-259603-bh198xgl	732	55	DNA	DNA	NNP
cord-259603-bh198xgl	732	56	exonucleases	exonuclease	NNS
cord-259603-bh198xgl	732	57	from	from	IN
cord-259603-bh198xgl	732	58	all	all	DT
cord-259603-bh198xgl	732	59	kingdoms	kingdom	NNS
cord-259603-bh198xgl	732	60	of	of	IN
cord-259603-bh198xgl	732	61	life	life	NN
cord-259603-bh198xgl	732	62	(	(	-LRB-
cord-259603-bh198xgl	732	63	Zuo	Zuo	NNP
cord-259603-bh198xgl	732	64	and	and	CC
cord-259603-bh198xgl	732	65	Deutscher	Deutscher	NNP
cord-259603-bh198xgl	732	66	,	,	,
cord-259603-bh198xgl	732	67	2001	2001	CD
cord-259603-bh198xgl	732	68	)	)	-RRB-
cord-259603-bh198xgl	732	69	.	.	.
cord-259603-bh198xgl	733	1	The	the	DT
cord-259603-bh198xgl	733	2	designation	designation	NN
cord-259603-bh198xgl	733	3	"	"	``
cord-259603-bh198xgl	733	4	DEDD	DEDD	NNP
cord-259603-bh198xgl	733	5	"	"	''
cord-259603-bh198xgl	733	6	alludes	allude	VBZ
cord-259603-bh198xgl	733	7	to	to	IN
cord-259603-bh198xgl	733	8	four	four	CD
cord-259603-bh198xgl	733	9	invariant	invariant	JJ
cord-259603-bh198xgl	733	10	Asp	Asp	NNP
cord-259603-bh198xgl	733	11	/	/	SYM
cord-259603-bh198xgl	733	12	Glu	Glu	NNP
cord-259603-bh198xgl	733	13	residues	residue	NNS
cord-259603-bh198xgl	733	14	that	that	WDT
cord-259603-bh198xgl	733	15	are	be	VBP
cord-259603-bh198xgl	733	16	part	part	NN
cord-259603-bh198xgl	733	17	of	of	IN
cord-259603-bh198xgl	733	18	three	three	CD
cord-259603-bh198xgl	733	19	sequence	sequence	NN
cord-259603-bh198xgl	733	20	motifs	motif	NNS
cord-259603-bh198xgl	733	21	,	,	,
cord-259603-bh198xgl	733	22	I	I	NNP
cord-259603-bh198xgl	733	23	-	-	HYPH
cord-259603-bh198xgl	733	24	III	III	NNP
cord-259603-bh198xgl	733	25	,	,	,
cord-259603-bh198xgl	733	26	that	that	WDT
cord-259603-bh198xgl	733	27	are	be	VBP
cord-259603-bh198xgl	733	28	conserved	conserve	VBN
cord-259603-bh198xgl	733	29	in	in	IN
cord-259603-bh198xgl	733	30	members	member	NNS
cord-259603-bh198xgl	733	31	of	of	IN
cord-259603-bh198xgl	733	32	this	this	DT
cord-259603-bh198xgl	733	33	superfamily	superfamily	NN
cord-259603-bh198xgl	733	34	(	(	-LRB-
cord-259603-bh198xgl	733	35	Fig	Fig	NNP
cord-259603-bh198xgl	733	36	.	.	.
cord-259603-bh198xgl	733	37	5	5	CD
cord-259603-bh198xgl	733	38	)	)	-RRB-
cord-259603-bh198xgl	733	39	.	.	.
cord-259603-bh198xgl	734	1	The	the	DT
cord-259603-bh198xgl	734	2	DEDD	DEDD	NNP
cord-259603-bh198xgl	734	3	superfamily	superfamily	NN
cord-259603-bh198xgl	734	4	is	be	VBZ
cord-259603-bh198xgl	734	5	also	also	RB
cord-259603-bh198xgl	734	6	referred	refer	VBN
cord-259603-bh198xgl	734	7	to	to	IN
cord-259603-bh198xgl	734	8	as	as	IN
cord-259603-bh198xgl	734	9	DnaQ	DnaQ	NNP
cord-259603-bh198xgl	734	10	-	-	HYPH
cord-259603-bh198xgl	734	11	like	like	JJ
cord-259603-bh198xgl	734	12	family	family	NN
cord-259603-bh198xgl	734	13	because	because	IN
cord-259603-bh198xgl	734	14	it	-PRON-	PRP
cord-259603-bh198xgl	734	15	includes	include	VBZ
cord-259603-bh198xgl	734	16	DnaQ	DnaQ	NNP
cord-259603-bh198xgl	734	17	,	,	,
cord-259603-bh198xgl	734	18	the	the	DT
cord-259603-bh198xgl	734	19	ε	ε	NNP
cord-259603-bh198xgl	734	20	subunit	subunit	NN
cord-259603-bh198xgl	734	21	of	of	IN
cord-259603-bh198xgl	734	22	E.	E.	NNP
cord-259603-bh198xgl	734	23	coli	coli	VBZ
cord-259603-bh198xgl	734	24	DNA	dna	NN
cord-259603-bh198xgl	734	25	polymerase	polymerase	NN
cord-259603-bh198xgl	734	26	III	III	NNP
cord-259603-bh198xgl	734	27	,	,	,
cord-259603-bh198xgl	734	28	a	a	DT
cord-259603-bh198xgl	734	29	well	well	RB
cord-259603-bh198xgl	734	30	-	-	HYPH
cord-259603-bh198xgl	734	31	characterized	characterize	VBN
cord-259603-bh198xgl	734	32	proofreading	proofreading	NN
cord-259603-bh198xgl	734	33	enzyme	enzyme	NN
cord-259603-bh198xgl	734	34	Scheuermann	Scheuermann	NNP
cord-259603-bh198xgl	734	35	et	et	NNP
cord-259603-bh198xgl	734	36	al	al	NNP
cord-259603-bh198xgl	734	37	.	.	NNP
cord-259603-bh198xgl	734	38	,	,	,
cord-259603-bh198xgl	734	39	1983	1983	CD
cord-259603-bh198xgl	734	40	)	)	-RRB-
cord-259603-bh198xgl	734	41	.	.	.
cord-259603-bh198xgl	735	1	Conservation	conservation	NN
cord-259603-bh198xgl	735	2	of	of	IN
cord-259603-bh198xgl	735	3	a	a	DT
cord-259603-bh198xgl	735	4	fifth	fifth	JJ
cord-259603-bh198xgl	735	5	residue	residue	NN
cord-259603-bh198xgl	735	6	,	,	,
cord-259603-bh198xgl	735	7	His	-PRON-	PRP$
cord-259603-bh198xgl	735	8	,	,	,
cord-259603-bh198xgl	735	9	located	locate	VBN
cord-259603-bh198xgl	735	10	four	four	CD
cord-259603-bh198xgl	735	11	positions	position	NNS
cord-259603-bh198xgl	735	12	upstream	upstream	RB
cord-259603-bh198xgl	735	13	of	of	IN
cord-259603-bh198xgl	735	14	the	the	DT
cord-259603-bh198xgl	735	15	conserved	conserved	JJ
cord-259603-bh198xgl	735	16	Asp	Asp	NNP
cord-259603-bh198xgl	735	17	in	in	IN
cord-259603-bh198xgl	736	1	motif	motif	NN
cord-259603-bh198xgl	736	2	III	III	NNP
cord-259603-bh198xgl	736	3	identifies	identify	VBZ
cord-259603-bh198xgl	736	4	ExoN	ExoN	NNP
cord-259603-bh198xgl	736	5	as	as	IN
cord-259603-bh198xgl	736	6	a	a	DT
cord-259603-bh198xgl	736	7	member	member	NN
cord-259603-bh198xgl	736	8	of	of	IN
cord-259603-bh198xgl	736	9	the	the	DT
cord-259603-bh198xgl	736	10	DEDDh	DEDDh	NNS
cord-259603-bh198xgl	736	11	subgroup	subgroup	NN
cord-259603-bh198xgl	736	12	,	,	,
cord-259603-bh198xgl	736	13	while	while	IN
cord-259603-bh198xgl	736	14	members	member	NNS
cord-259603-bh198xgl	736	15	of	of	IN
cord-259603-bh198xgl	736	16	the	the	DT
cord-259603-bh198xgl	736	17	DEDDy	deddy	NN
cord-259603-bh198xgl	736	18	exonucleases	exonuclease	NNS
cord-259603-bh198xgl	736	19	contain	contain	VBP
cord-259603-bh198xgl	736	20	Tyr	Tyr	NNP
cord-259603-bh198xgl	736	21	at	at	IN
cord-259603-bh198xgl	736	22	the	the	DT
cord-259603-bh198xgl	736	23	equivalent	equivalent	JJ
cord-259603-bh198xgl	736	24	position	position	NN
cord-259603-bh198xgl	736	25	.	.	.
cord-259603-bh198xgl	737	1	The	the	DT
cord-259603-bh198xgl	737	2	acidic	acidic	JJ
cord-259603-bh198xgl	737	3	residues	residue	NNS
cord-259603-bh198xgl	737	4	are	be	VBP
cord-259603-bh198xgl	737	5	required	require	VBN
cord-259603-bh198xgl	737	6	to	to	TO
cord-259603-bh198xgl	737	7	form	form	VB
cord-259603-bh198xgl	737	8	two	two	CD
cord-259603-bh198xgl	737	9	metal	metal	NN
cord-259603-bh198xgl	737	10	-	-	HYPH
cord-259603-bh198xgl	737	11	binding	bind	VBG
cord-259603-bh198xgl	737	12	sites	site	NNS
cord-259603-bh198xgl	737	13	.	.	.
cord-259603-bh198xgl	738	1	Based	base	VBN
cord-259603-bh198xgl	738	2	on	on	IN
cord-259603-bh198xgl	738	3	catalytic	catalytic	JJ
cord-259603-bh198xgl	738	4	models	model	NNS
cord-259603-bh198xgl	738	5	initially	initially	RB
cord-259603-bh198xgl	738	6	developed	develop	VBN
cord-259603-bh198xgl	738	7	for	for	IN
cord-259603-bh198xgl	738	8	cellular	cellular	JJ
cord-259603-bh198xgl	738	9	exonucleases	exonuclease	NNS
cord-259603-bh198xgl	738	10	and	and	CC
cord-259603-bh198xgl	738	11	catalytic	catalytic	JJ
cord-259603-bh198xgl	738	12	RNA	RNA	NNP
cord-259603-bh198xgl	738	13	(	(	-LRB-
cord-259603-bh198xgl	738	14	Beese	Beese	NNP
cord-259603-bh198xgl	738	15	and	and	CC
cord-259603-bh198xgl	738	16	Steitz	Steitz	NNP
cord-259603-bh198xgl	738	17	,	,	,
cord-259603-bh198xgl	738	18	1991	1991	CD
cord-259603-bh198xgl	738	19	;	;	:
cord-259603-bh198xgl	738	20	Steitz	Steitz	NNP
cord-259603-bh198xgl	738	21	and	and	CC
cord-259603-bh198xgl	738	22	Steitz	Steitz	NNP
cord-259603-bh198xgl	738	23	,	,	,
cord-259603-bh198xgl	738	24	1993	1993	CD
cord-259603-bh198xgl	738	25	)	)	-RRB-
cord-259603-bh198xgl	738	26	,	,	,
cord-259603-bh198xgl	738	27	the	the	DT
cord-259603-bh198xgl	738	28	conserved	conserve	VBN
cord-259603-bh198xgl	738	29	His	-PRON-	PRP$
cord-259603-bh198xgl	738	30	and	and	CC
cord-259603-bh198xgl	738	31	the	the	DT
cord-259603-bh198xgl	738	32	site	site	NN
cord-259603-bh198xgl	738	33	A	a	DT
cord-259603-bh198xgl	738	34	metal	metal	NN
cord-259603-bh198xgl	738	35	ion	ion	NN
cord-259603-bh198xgl	738	36	are	be	VBP
cord-259603-bh198xgl	738	37	thought	think	VBN
cord-259603-bh198xgl	738	38	to	to	TO
cord-259603-bh198xgl	738	39	activate	activate	VB
cord-259603-bh198xgl	738	40	a	a	DT
cord-259603-bh198xgl	738	41	water	water	NN
cord-259603-bh198xgl	738	42	molecule	molecule	NN
cord-259603-bh198xgl	738	43	that	that	WDT
cord-259603-bh198xgl	738	44	launches	launch	VBZ
cord-259603-bh198xgl	738	45	a	a	DT
cord-259603-bh198xgl	738	46	nucleophilic	nucleophilic	JJ
cord-259603-bh198xgl	738	47	attack	attack	NN
cord-259603-bh198xgl	738	48	on	on	IN
cord-259603-bh198xgl	738	49	the	the	DT
cord-259603-bh198xgl	738	50	phosphorus	phosphorus	NN
cord-259603-bh198xgl	738	51	group	group	NN
cord-259603-bh198xgl	738	52	of	of	IN
cord-259603-bh198xgl	738	53	the	the	DT
cord-259603-bh198xgl	738	54	3	3	CD
cord-259603-bh198xgl	738	55	0	0	CD
cord-259603-bh198xgl	738	56	-terminal	-terminal	JJ
cord-259603-bh198xgl	738	57	phosphodiester	phosphodiester	NN
cord-259603-bh198xgl	738	58	,	,	,
cord-259603-bh198xgl	738	59	while	while	IN
cord-259603-bh198xgl	738	60	the	the	DT
cord-259603-bh198xgl	738	61	site	site	NN
cord-259603-bh198xgl	738	62	B	b	NN
cord-259603-bh198xgl	738	63	metal	metal	NN
cord-259603-bh198xgl	738	64	ion	ion	NN
cord-259603-bh198xgl	738	65	is	be	VBZ
cord-259603-bh198xgl	738	66	thought	think	VBN
cord-259603-bh198xgl	738	67	to	to	TO
cord-259603-bh198xgl	738	68	stabilize	stabilize	VB
cord-259603-bh198xgl	738	69	the	the	DT
cord-259603-bh198xgl	738	70	transition	transition	NN
cord-259603-bh198xgl	738	71	state	state	NN
cord-259603-bh198xgl	738	72	(	(	-LRB-
cord-259603-bh198xgl	738	73	Derbyshire	Derbyshire	NNP
cord-259603-bh198xgl	738	74	et	et	NNP
cord-259603-bh198xgl	738	75	al	al	NNP
cord-259603-bh198xgl	738	76	.	.	NNP
cord-259603-bh198xgl	738	77	,	,	,
cord-259603-bh198xgl	738	78	1991	1991	CD
cord-259603-bh198xgl	738	79	)	)	-RRB-
cord-259603-bh198xgl	738	80	.	.	.
cord-259603-bh198xgl	739	1	ExoN	ExoN	NNP
cord-259603-bh198xgl	739	2	is	be	VBZ
cord-259603-bh198xgl	739	3	conserved	conserve	VBN
cord-259603-bh198xgl	739	4	in	in	IN
cord-259603-bh198xgl	739	5	CoVs	CoVs	NNP
cord-259603-bh198xgl	739	6	and	and	CC
cord-259603-bh198xgl	739	7	all	all	DT
cord-259603-bh198xgl	739	8	other	other	JJ
cord-259603-bh198xgl	739	9	known	know	VBN
cord-259603-bh198xgl	739	10	nidoviruses	nidoviruse	NNS
cord-259603-bh198xgl	739	11	with	with	IN
cord-259603-bh198xgl	739	12	genome	genome	NN
cord-259603-bh198xgl	739	13	sizes	size	NNS
cord-259603-bh198xgl	739	14	of	of	IN
cord-259603-bh198xgl	739	15	>	>	$
cord-259603-bh198xgl	739	16	20	20	CD
cord-259603-bh198xgl	739	17	kb	kb	NNP
cord-259603-bh198xgl	739	18	Minskaia	Minskaia	NNP
cord-259603-bh198xgl	739	19	et	et	NNP
cord-259603-bh198xgl	739	20	al	al	NNP
cord-259603-bh198xgl	739	21	.	.	NNP
cord-259603-bh198xgl	739	22	,	,	,
cord-259603-bh198xgl	739	23	2006	2006	CD
cord-259603-bh198xgl	739	24	;	;	:
cord-259603-bh198xgl	739	25	Nga	Nga	NNP
cord-259603-bh198xgl	739	26	et	et	NNP
cord-259603-bh198xgl	739	27	al	al	NNP
cord-259603-bh198xgl	739	28	.	.	.
cord-259603-bh198xgl	740	1	,	,	,
cord-259603-bh198xgl	740	2	2011	2011	CD
cord-259603-bh198xgl	740	3	;	;	:
cord-259603-bh198xgl	740	4	Snijder	Snijder	NNP
cord-259603-bh198xgl	740	5	et	et	NNP
cord-259603-bh198xgl	740	6	al	al	NNP
cord-259603-bh198xgl	740	7	.	.	NNP
cord-259603-bh198xgl	740	8	,	,	,
cord-259603-bh198xgl	740	9	2003	2003	CD
cord-259603-bh198xgl	740	10	;	;	:
cord-259603-bh198xgl	740	11	Zirkel	Zirkel	NNP
cord-259603-bh198xgl	740	12	et	et	NNP
cord-259603-bh198xgl	740	13	al	al	NNP
cord-259603-bh198xgl	740	14	.	.	NNP
cord-259603-bh198xgl	740	15	,	,	,
cord-259603-bh198xgl	740	16	2011	2011	CD
cord-259603-bh198xgl	740	17	)	)	-RRB-
cord-259603-bh198xgl	740	18	.	.	.
cord-259603-bh198xgl	741	1	The	the	DT
cord-259603-bh198xgl	741	2	correlation	correlation	NN
cord-259603-bh198xgl	741	3	between	between	IN
cord-259603-bh198xgl	741	4	genome	genome	NN
cord-259603-bh198xgl	741	5	size	size	NN
cord-259603-bh198xgl	741	6	and	and	CC
cord-259603-bh198xgl	741	7	ExoN	ExoN	NNP
cord-259603-bh198xgl	741	8	conservation	conservation	NN
cord-259603-bh198xgl	741	9	suggests	suggest	VBZ
cord-259603-bh198xgl	741	10	that	that	IN
cord-259603-bh198xgl	741	11	,	,	,
cord-259603-bh198xgl	741	12	in	in	IN
cord-259603-bh198xgl	741	13	nidoviruses	nidoviruse	NNS
cord-259603-bh198xgl	741	14	with	with	IN
cord-259603-bh198xgl	741	15	medium	medium	NN
cord-259603-bh198xgl	741	16	-	-	HYPH
cord-259603-bh198xgl	741	17	and	and	CC
cord-259603-bh198xgl	741	18	large	large	JJ
cord-259603-bh198xgl	741	19	-	-	HYPH
cord-259603-bh198xgl	741	20	size	size	NN
cord-259603-bh198xgl	741	21	genomes	genome	NNS
cord-259603-bh198xgl	741	22	,	,	,
cord-259603-bh198xgl	741	23	the	the	DT
cord-259603-bh198xgl	741	24	correct	correct	JJ
cord-259603-bh198xgl	741	25	nucleotide	nucleotide	JJ
cord-259603-bh198xgl	741	26	selection	selection	NN
cord-259603-bh198xgl	741	27	and	and	CC
cord-259603-bh198xgl	741	28	recognition	recognition	NN
cord-259603-bh198xgl	741	29	of	of	IN
cord-259603-bh198xgl	741	30	properly	properly	RB
cord-259603-bh198xgl	741	31	formed	form	VBN
cord-259603-bh198xgl	741	32	base	base	NN
cord-259603-bh198xgl	741	33	pairs	pair	NNS
cord-259603-bh198xgl	741	34	by	by	IN
cord-259603-bh198xgl	741	35	the	the	DT
cord-259603-bh198xgl	741	36	RdRp	RdRp	NNP
cord-259603-bh198xgl	741	37	is	be	VBZ
cord-259603-bh198xgl	741	38	not	not	RB
cord-259603-bh198xgl	741	39	enough	enough	JJ
cord-259603-bh198xgl	741	40	to	to	TO
cord-259603-bh198xgl	741	41	accomplish	accomplish	VB
cord-259603-bh198xgl	741	42	the	the	DT
cord-259603-bh198xgl	741	43	necessary	necessary	JJ
cord-259603-bh198xgl	741	44	replication	replication	NN
cord-259603-bh198xgl	741	45	fidelity	fidelity	NN
cord-259603-bh198xgl	741	46	and	and	CC
cord-259603-bh198xgl	741	47	,	,	,
cord-259603-bh198xgl	741	48	therefore	therefore	RB
cord-259603-bh198xgl	741	49	,	,	,
cord-259603-bh198xgl	741	50	requires	require	VBZ
cord-259603-bh198xgl	741	51	additional	additional	JJ
cord-259603-bh198xgl	741	52	functions	function	NNS
cord-259603-bh198xgl	741	53	suitable	suitable	JJ
cord-259603-bh198xgl	741	54	to	to	TO
cord-259603-bh198xgl	741	55	detect	detect	VB
cord-259603-bh198xgl	741	56	and	and	CC
cord-259603-bh198xgl	741	57	remove	remove	VB
cord-259603-bh198xgl	741	58	misincorporated	misincorporated	JJ
cord-259603-bh198xgl	741	59	nucleotides	nucleotide	NNS
cord-259603-bh198xgl	741	60	.	.	.
cord-259603-bh198xgl	742	1	Recently	recently	RB
cord-259603-bh198xgl	742	2	,	,	,
cord-259603-bh198xgl	742	3	biochemical	biochemical	JJ
cord-259603-bh198xgl	742	4	evidence	evidence	NN
cord-259603-bh198xgl	742	5	has	have	VBZ
cord-259603-bh198xgl	742	6	been	be	VBN
cord-259603-bh198xgl	742	7	provided	provide	VBN
cord-259603-bh198xgl	742	8	to	to	TO
cord-259603-bh198xgl	742	9	suggest	suggest	VB
cord-259603-bh198xgl	742	10	that	that	IN
cord-259603-bh198xgl	742	11	ExoN	ExoN	NNP
cord-259603-bh198xgl	742	12	may	may	MD
cord-259603-bh198xgl	742	13	have	have	VB
cord-259603-bh198xgl	742	14	exactly	exactly	RB
cord-259603-bh198xgl	742	15	this	this	DT
cord-259603-bh198xgl	742	16	function	function	NN
cord-259603-bh198xgl	742	17	(	(	-LRB-
cord-259603-bh198xgl	742	18	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	742	19	et	et	NNP
cord-259603-bh198xgl	742	20	al	al	NNP
cord-259603-bh198xgl	742	21	.	.	NNP
cord-259603-bh198xgl	742	22	,	,	,
cord-259603-bh198xgl	742	23	2012	2012	CD
cord-259603-bh198xgl	742	24	)	)	-RRB-
cord-259603-bh198xgl	742	25	.	.	.
cord-259603-bh198xgl	743	1	CoV	CoV	NNP
cord-259603-bh198xgl	743	2	mutants	mutant	NNS
cord-259603-bh198xgl	743	3	that	that	WDT
cord-259603-bh198xgl	743	4	lack	lack	VBP
cord-259603-bh198xgl	743	5	ExoN	ExoN	NNP
cord-259603-bh198xgl	743	6	activity	activity	NN
cord-259603-bh198xgl	743	7	provided	provide	VBD
cord-259603-bh198xgl	743	8	additional	additional	JJ
cord-259603-bh198xgl	743	9	evidence	evidence	NN
cord-259603-bh198xgl	743	10	for	for	IN
cord-259603-bh198xgl	743	11	ExoN	ExoN	NNP
cord-259603-bh198xgl	743	12	being	be	VBG
cord-259603-bh198xgl	743	13	involved	involve	VBN
cord-259603-bh198xgl	743	14	in	in	IN
cord-259603-bh198xgl	743	15	mechanisms	mechanism	NNS
cord-259603-bh198xgl	743	16	that	that	WDT
cord-259603-bh198xgl	743	17	keep	keep	VBP
cord-259603-bh198xgl	743	18	the	the	DT
cord-259603-bh198xgl	743	19	CoV	cov	NN
cord-259603-bh198xgl	743	20	mutation	mutation	NN
cord-259603-bh198xgl	743	21	rate	rate	NN
cord-259603-bh198xgl	743	22	at	at	IN
cord-259603-bh198xgl	743	23	a	a	DT
cord-259603-bh198xgl	743	24	relatively	relatively	RB
cord-259603-bh198xgl	743	25	low	low	JJ
cord-259603-bh198xgl	743	26	level	level	NN
cord-259603-bh198xgl	743	27	(	(	-LRB-
cord-259603-bh198xgl	743	28	<	<	NNP
cord-259603-bh198xgl	743	29	10	10	CD
cord-259603-bh198xgl	743	30	À6	À6	NNP
cord-259603-bh198xgl	743	31	mutations	mutation	NNS
cord-259603-bh198xgl	743	32	per	per	IN
cord-259603-bh198xgl	743	33	site	site	NN
cord-259603-bh198xgl	743	34	per	per	IN
cord-259603-bh198xgl	743	35	round	round	NN
cord-259603-bh198xgl	743	36	of	of	IN
cord-259603-bh198xgl	743	37	replication	replication	NN
cord-259603-bh198xgl	743	38	for	for	IN
cord-259603-bh198xgl	743	39	MHV	MHV	NNP
cord-259603-bh198xgl	743	40	and	and	CC
cord-259603-bh198xgl	743	41	SARS	SARS	NNP
cord-259603-bh198xgl	743	42	-	-	HYPH
cord-259603-bh198xgl	743	43	CoV	CoV	NNP
cord-259603-bh198xgl	743	44	)	)	-RRB-
cord-259603-bh198xgl	744	1	(	(	-LRB-
cord-259603-bh198xgl	744	2	Eckerle	Eckerle	NNP
cord-259603-bh198xgl	744	3	et	et	NNP
cord-259603-bh198xgl	744	4	al	al	NNP
cord-259603-bh198xgl	744	5	.	.	NNP
cord-259603-bh198xgl	744	6	,	,	,
cord-259603-bh198xgl	744	7	2007	2007	CD
cord-259603-bh198xgl	745	1	(	(	-LRB-
cord-259603-bh198xgl	745	2	Eckerle	Eckerle	NNP
cord-259603-bh198xgl	745	3	et	et	NNP
cord-259603-bh198xgl	745	4	al	al	NNP
cord-259603-bh198xgl	745	5	.	.	NNP
cord-259603-bh198xgl	745	6	,	,	,
cord-259603-bh198xgl	745	7	,	,	,
cord-259603-bh198xgl	745	8	2010	2010	CD
cord-259603-bh198xgl	745	9	,	,	,
cord-259603-bh198xgl	745	10	while	while	IN
cord-259603-bh198xgl	745	11	other	other	JJ
cord-259603-bh198xgl	745	12	RNA	RNA	NNP
cord-259603-bh198xgl	745	13	viruses	virus	NNS
cord-259603-bh198xgl	745	14	have	have	VBP
cord-259603-bh198xgl	745	15	much	much	RB
cord-259603-bh198xgl	745	16	higher	high	JJR
cord-259603-bh198xgl	745	17	mutation	mutation	NN
cord-259603-bh198xgl	745	18	rates	rate	NNS
cord-259603-bh198xgl	745	19	,	,	,
cord-259603-bh198xgl	745	20	ranging	range	VBG
cord-259603-bh198xgl	745	21	from	from	IN
cord-259603-bh198xgl	745	22	10	10	CD
cord-259603-bh198xgl	745	23	À3	à3	CD
cord-259603-bh198xgl	745	24	to	to	IN
cord-259603-bh198xgl	745	25	10	10	CD
cord-259603-bh198xgl	745	26	À5	À5	NNP
cord-259603-bh198xgl	745	27	mutations	mutation	NNS
cord-259603-bh198xgl	745	28	per	per	IN
cord-259603-bh198xgl	745	29	site	site	NN
cord-259603-bh198xgl	745	30	per	per	IN
cord-259603-bh198xgl	745	31	round	round	NN
cord-259603-bh198xgl	745	32	of	of	IN
cord-259603-bh198xgl	745	33	replication	replication	NN
cord-259603-bh198xgl	745	34	(	(	-LRB-
cord-259603-bh198xgl	745	35	Drake	Drake	NNP
cord-259603-bh198xgl	745	36	and	and	CC
cord-259603-bh198xgl	745	37	Holland	Holland	NNP
cord-259603-bh198xgl	745	38	,	,	,
cord-259603-bh198xgl	745	39	1999	1999	CD
cord-259603-bh198xgl	745	40	;	;	:
cord-259603-bh198xgl	746	1	Sanjuan	Sanjuan	NNP
cord-259603-bh198xgl	746	2	et	et	NNP
cord-259603-bh198xgl	746	3	al	al	NNP
cord-259603-bh198xgl	746	4	.	.	NNP
cord-259603-bh198xgl	746	5	,	,	,
cord-259603-bh198xgl	746	6	2010	2010	CD
cord-259603-bh198xgl	746	7	)	)	-RRB-
cord-259603-bh198xgl	746	8	.	.	.
cord-259603-bh198xgl	747	1	ExoN	exon	NN
cord-259603-bh198xgl	747	2	knockout	knockout	NN
cord-259603-bh198xgl	747	3	mutants	mutant	NNS
cord-259603-bh198xgl	747	4	of	of	IN
cord-259603-bh198xgl	747	5	SARS	SARS	NNP
cord-259603-bh198xgl	747	6	-	-	HYPH
cord-259603-bh198xgl	747	7	CoV	CoV	NNP
cord-259603-bh198xgl	747	8	and	and	CC
cord-259603-bh198xgl	747	9	MHV	MHV	NNP
cord-259603-bh198xgl	747	10	were	be	VBD
cord-259603-bh198xgl	747	11	shown	show	VBN
cord-259603-bh198xgl	747	12	to	to	TO
cord-259603-bh198xgl	747	13	display	display	VB
cord-259603-bh198xgl	747	14	a	a	DT
cord-259603-bh198xgl	747	15	mutator	mutator	NN
cord-259603-bh198xgl	747	16	phenotype	phenotype	NN
cord-259603-bh198xgl	747	17	with	with	IN
cord-259603-bh198xgl	747	18	significantly	significantly	RB
cord-259603-bh198xgl	747	19	increased	increase	VBN
cord-259603-bh198xgl	747	20	mutation	mutation	NN
cord-259603-bh198xgl	747	21	frequencies	frequency	NNS
cord-259603-bh198xgl	747	22	approaching	approach	VBG
cord-259603-bh198xgl	747	23	those	those	DT
cord-259603-bh198xgl	747	24	of	of	IN
cord-259603-bh198xgl	747	25	other	other	JJ
cord-259603-bh198xgl	747	26	RNA	RNA	NNP
cord-259603-bh198xgl	747	27	viruses	virus	NNS
cord-259603-bh198xgl	747	28	(	(	-LRB-
cord-259603-bh198xgl	747	29	Eckerle	Eckerle	NNP
cord-259603-bh198xgl	747	30	et	et	NNP
cord-259603-bh198xgl	747	31	al	al	NNP
cord-259603-bh198xgl	747	32	.	.	NNP
cord-259603-bh198xgl	747	33	,	,	,
cord-259603-bh198xgl	747	34	2007	2007	CD
cord-259603-bh198xgl	748	1	(	(	-LRB-
cord-259603-bh198xgl	748	2	Eckerle	Eckerle	NNP
cord-259603-bh198xgl	748	3	et	et	NNP
cord-259603-bh198xgl	748	4	al	al	NNP
cord-259603-bh198xgl	748	5	.	.	NNP
cord-259603-bh198xgl	748	6	,	,	,
cord-259603-bh198xgl	748	7	,	,	,
cord-259603-bh198xgl	748	8	2010	2010	CD
cord-259603-bh198xgl	748	9	.	.	.
cord-259603-bh198xgl	749	1	Considering	consider	VBG
cord-259603-bh198xgl	749	2	that	that	IN
cord-259603-bh198xgl	749	3	these	these	DT
cord-259603-bh198xgl	749	4	studies	study	NNS
cord-259603-bh198xgl	749	5	were	be	VBD
cord-259603-bh198xgl	749	6	performed	perform	VBN
cord-259603-bh198xgl	749	7	under	under	IN
cord-259603-bh198xgl	749	8	selection	selection	NN
cord-259603-bh198xgl	749	9	pressure	pressure	NN
cord-259603-bh198xgl	749	10	favoring	favor	VBG
cord-259603-bh198xgl	749	11	genotypes	genotype	NNS
cord-259603-bh198xgl	749	12	with	with	IN
cord-259603-bh198xgl	749	13	high	high	JJ
cord-259603-bh198xgl	749	14	replication	replication	NN
cord-259603-bh198xgl	749	15	efficiency	efficiency	NN
cord-259603-bh198xgl	749	16	,	,	,
cord-259603-bh198xgl	749	17	the	the	DT
cord-259603-bh198xgl	749	18	total	total	JJ
cord-259603-bh198xgl	749	19	number	number	NN
cord-259603-bh198xgl	749	20	of	of	IN
cord-259603-bh198xgl	749	21	mutations	mutation	NNS
cord-259603-bh198xgl	749	22	in	in	IN
cord-259603-bh198xgl	749	23	RNAs	rna	NNS
cord-259603-bh198xgl	749	24	produced	produce	VBN
cord-259603-bh198xgl	749	25	by	by	IN
cord-259603-bh198xgl	749	26	ExoN	exon	NN
cord-259603-bh198xgl	749	27	-	-	HYPH
cord-259603-bh198xgl	749	28	deficient	deficient	JJ
cord-259603-bh198xgl	749	29	viruses	virus	NNS
cord-259603-bh198xgl	749	30	may	may	MD
cord-259603-bh198xgl	749	31	be	be	VB
cord-259603-bh198xgl	749	32	even	even	RB
cord-259603-bh198xgl	749	33	higher	high	JJR
cord-259603-bh198xgl	749	34	than	than	IN
cord-259603-bh198xgl	749	35	calculated	calculate	VBN
cord-259603-bh198xgl	749	36	in	in	IN
cord-259603-bh198xgl	749	37	that	that	DT
cord-259603-bh198xgl	749	38	study	study	NN
cord-259603-bh198xgl	749	39	,	,	,
cord-259603-bh198xgl	749	40	especially	especially	RB
cord-259603-bh198xgl	749	41	in	in	IN
cord-259603-bh198xgl	749	42	genome	genome	NN
cord-259603-bh198xgl	749	43	regions	region	NNS
cord-259603-bh198xgl	749	44	that	that	WDT
cord-259603-bh198xgl	749	45	are	be	VBP
cord-259603-bh198xgl	749	46	not	not	RB
cord-259603-bh198xgl	749	47	subject	subject	JJ
cord-259603-bh198xgl	749	48	to	to	IN
cord-259603-bh198xgl	749	49	selection	selection	NN
cord-259603-bh198xgl	749	50	in	in	RP
cord-259603-bh198xgl	749	51	in	in	IN
cord-259603-bh198xgl	749	52	vitro	vitro	FW
cord-259603-bh198xgl	749	53	cell	cell	NN
cord-259603-bh198xgl	749	54	culture	culture	NN
cord-259603-bh198xgl	749	55	systems	system	NNS
cord-259603-bh198xgl	749	56	.	.	.
cord-259603-bh198xgl	750	1	While	while	IN
cord-259603-bh198xgl	750	2	inactivation	inactivation	NN
cord-259603-bh198xgl	750	3	of	of	IN
cord-259603-bh198xgl	750	4	ExoN	ExoN	NNP
cord-259603-bh198xgl	750	5	activity	activity	NN
cord-259603-bh198xgl	750	6	was	be	VBD
cord-259603-bh198xgl	750	7	tolerated	tolerate	VBN
cord-259603-bh198xgl	750	8	by	by	IN
cord-259603-bh198xgl	750	9	MHV	MHV	NNP
cord-259603-bh198xgl	750	10	and	and	CC
cord-259603-bh198xgl	750	11	SARS	SARS	NNP
cord-259603-bh198xgl	750	12	-	-	HYPH
cord-259603-bh198xgl	750	13	CoV	CoV	NNP
cord-259603-bh198xgl	750	14	(	(	-LRB-
cord-259603-bh198xgl	750	15	albeit	albeit	IN
cord-259603-bh198xgl	750	16	with	with	IN
cord-259603-bh198xgl	750	17	reductions	reduction	NNS
cord-259603-bh198xgl	750	18	in	in	IN
cord-259603-bh198xgl	750	19	replication	replication	NN
cord-259603-bh198xgl	750	20	efficiency	efficiency	NN
cord-259603-bh198xgl	750	21	)	)	-RRB-
cord-259603-bh198xgl	750	22	,	,	,
cord-259603-bh198xgl	750	23	stable	stable	JJ
cord-259603-bh198xgl	750	24	ExoN	exon	NN
cord-259603-bh198xgl	750	25	-	-	HYPH
cord-259603-bh198xgl	750	26	deficient	deficient	JJ
cord-259603-bh198xgl	750	27	mutants	mutant	NNS
cord-259603-bh198xgl	750	28	of	of	IN
cord-259603-bh198xgl	750	29	the	the	DT
cord-259603-bh198xgl	750	30	alphacoronaviruses	alphacoronaviruses	NNP
cord-259603-bh198xgl	750	31	HCoV-229E	HCoV-229E	NNP
cord-259603-bh198xgl	750	32	and	and	CC
cord-259603-bh198xgl	750	33	TGEV	TGEV	NNP
cord-259603-bh198xgl	750	34	could	could	MD
cord-259603-bh198xgl	750	35	not	not	RB
cord-259603-bh198xgl	750	36	be	be	VB
cord-259603-bh198xgl	750	37	recovered	recover	VBN
cord-259603-bh198xgl	751	1	(	(	-LRB-
cord-259603-bh198xgl	751	2	Becares	Becares	NNP
cord-259603-bh198xgl	751	3	et	et	NNP
cord-259603-bh198xgl	751	4	al	al	NNP
cord-259603-bh198xgl	751	5	.	.	.
cord-259603-bh198xgl	752	1	,	,	,
cord-259603-bh198xgl	752	2	2016	2016	CD
cord-259603-bh198xgl	752	3	;	;	:
cord-259603-bh198xgl	752	4	Minskaia	Minskaia	NNP
cord-259603-bh198xgl	752	5	et	et	NNP
cord-259603-bh198xgl	752	6	al	al	NNP
cord-259603-bh198xgl	752	7	.	.	NNP
cord-259603-bh198xgl	752	8	,	,	,
cord-259603-bh198xgl	752	9	2006	2006	CD
cord-259603-bh198xgl	752	10	)	)	-RRB-
cord-259603-bh198xgl	752	11	,	,	,
cord-259603-bh198xgl	752	12	supporting	support	VBG
cord-259603-bh198xgl	752	13	the	the	DT
cord-259603-bh198xgl	752	14	critical	critical	JJ
cord-259603-bh198xgl	752	15	role	role	NN
cord-259603-bh198xgl	752	16	of	of	IN
cord-259603-bh198xgl	752	17	this	this	DT
cord-259603-bh198xgl	752	18	activity	activity	NN
cord-259603-bh198xgl	752	19	in	in	IN
cord-259603-bh198xgl	752	20	CoV	cov	NN
cord-259603-bh198xgl	752	21	replication	replication	NN
cord-259603-bh198xgl	752	22	.	.	.
cord-259603-bh198xgl	753	1	Taken	take	VBN
cord-259603-bh198xgl	753	2	together	together	RB
cord-259603-bh198xgl	753	3	,	,	,
cord-259603-bh198xgl	753	4	the	the	DT
cord-259603-bh198xgl	753	5	available	available	JJ
cord-259603-bh198xgl	753	6	information	information	NN
cord-259603-bh198xgl	753	7	provides	provide	VBZ
cord-259603-bh198xgl	753	8	compelling	compelling	JJ
cord-259603-bh198xgl	753	9	evidence	evidence	NN
cord-259603-bh198xgl	753	10	for	for	IN
cord-259603-bh198xgl	753	11	ExoN	ExoN	NNP
cord-259603-bh198xgl	753	12	playing	play	VBG
cord-259603-bh198xgl	753	13	a	a	DT
cord-259603-bh198xgl	753	14	key	key	JJ
cord-259603-bh198xgl	753	15	role	role	NN
cord-259603-bh198xgl	753	16	in	in	IN
cord-259603-bh198xgl	753	17	high	high	JJ
cord-259603-bh198xgl	753	18	-	-	HYPH
cord-259603-bh198xgl	753	19	fidelity	fidelity	NN
cord-259603-bh198xgl	753	20	replication	replication	NN
cord-259603-bh198xgl	753	21	of	of	IN
cord-259603-bh198xgl	753	22	CoVs	CoVs	NNP
cord-259603-bh198xgl	753	23	.	.	.
cord-259603-bh198xgl	754	1	Consistent	consistent	JJ
cord-259603-bh198xgl	754	2	with	with	IN
cord-259603-bh198xgl	754	3	this	this	DT
cord-259603-bh198xgl	754	4	hypothesis	hypothesis	NN
cord-259603-bh198xgl	754	5	,	,	,
cord-259603-bh198xgl	754	6	genetically	genetically	RB
cord-259603-bh198xgl	754	7	engineered	engineer	VBN
cord-259603-bh198xgl	754	8	ExoN	ExoN	NNP
cord-259603-bh198xgl	754	9	knockout	knockout	NN
cord-259603-bh198xgl	754	10	mutants	mutant	NNS
cord-259603-bh198xgl	754	11	were	be	VBD
cord-259603-bh198xgl	754	12	shown	show	VBN
cord-259603-bh198xgl	754	13	to	to	TO
cord-259603-bh198xgl	754	14	be	be	VB
cord-259603-bh198xgl	754	15	significantly	significantly	RB
cord-259603-bh198xgl	754	16	more	more	RBR
cord-259603-bh198xgl	754	17	sensitive	sensitive	JJ
cord-259603-bh198xgl	754	18	to	to	IN
cord-259603-bh198xgl	754	19	RNA	RNA	NNP
cord-259603-bh198xgl	754	20	mutagens	mutagen	NNS
cord-259603-bh198xgl	754	21	such	such	JJ
cord-259603-bh198xgl	754	22	as	as	IN
cord-259603-bh198xgl	754	23	ribavirin	ribavirin	NN
cord-259603-bh198xgl	754	24	and	and	CC
cord-259603-bh198xgl	754	25	5-fluorouracil	5-fluorouracil	CD
cord-259603-bh198xgl	754	26	(	(	-LRB-
cord-259603-bh198xgl	754	27	up	up	IN
cord-259603-bh198xgl	754	28	to	to	IN
cord-259603-bh198xgl	754	29	300-fold	300-fold	CD
cord-259603-bh198xgl	754	30	)	)	-RRB-
cord-259603-bh198xgl	754	31	.	.	.
cord-259603-bh198xgl	755	1	Furthermore	furthermore	RB
cord-259603-bh198xgl	755	2	,	,	,
cord-259603-bh198xgl	755	3	compared	compare	VBN
cord-259603-bh198xgl	755	4	to	to	IN
cord-259603-bh198xgl	755	5	wild	wild	JJ
cord-259603-bh198xgl	755	6	-	-	HYPH
cord-259603-bh198xgl	755	7	type	type	NN
cord-259603-bh198xgl	755	8	virus	virus	NN
cord-259603-bh198xgl	755	9	,	,	,
cord-259603-bh198xgl	755	10	the	the	DT
cord-259603-bh198xgl	755	11	ExoN	ExoN	NNP
cord-259603-bh198xgl	755	12	knockout	knockout	NN
cord-259603-bh198xgl	755	13	mutants	mutant	NNS
cord-259603-bh198xgl	755	14	were	be	VBD
cord-259603-bh198xgl	755	15	shown	show	VBN
cord-259603-bh198xgl	755	16	to	to	TO
cord-259603-bh198xgl	755	17	accumulate	accumulate	VB
cord-259603-bh198xgl	755	18	a	a	DT
cord-259603-bh198xgl	755	19	much	much	RB
cord-259603-bh198xgl	755	20	higher	high	JJR
cord-259603-bh198xgl	755	21	number	number	NN
cord-259603-bh198xgl	755	22	of	of	IN
cord-259603-bh198xgl	755	23	mutations	mutation	NNS
cord-259603-bh198xgl	755	24	when	when	WRB
cord-259603-bh198xgl	755	25	propagated	propagate	VBN
cord-259603-bh198xgl	755	26	in	in	IN
cord-259603-bh198xgl	755	27	the	the	DT
cord-259603-bh198xgl	755	28	presence	presence	NN
cord-259603-bh198xgl	755	29	of	of	IN
cord-259603-bh198xgl	755	30	mutagens	mutagen	NNS
cord-259603-bh198xgl	755	31	(	(	-LRB-
cord-259603-bh198xgl	755	32	Smith	Smith	NNP
cord-259603-bh198xgl	755	33	et	et	NNP
cord-259603-bh198xgl	755	34	al	al	NNP
cord-259603-bh198xgl	755	35	.	.	NNP
cord-259603-bh198xgl	755	36	,	,	,
cord-259603-bh198xgl	755	37	2013	2013	CD
cord-259603-bh198xgl	755	38	)	)	-RRB-
cord-259603-bh198xgl	755	39	.	.	.
cord-259603-bh198xgl	756	1	The	the	DT
cord-259603-bh198xgl	756	2	lack	lack	NN
cord-259603-bh198xgl	756	3	of	of	IN
cord-259603-bh198xgl	756	4	ExoN	ExoN	NNP
cord-259603-bh198xgl	756	5	activity	activity	NN
cord-259603-bh198xgl	756	6	was	be	VBD
cord-259603-bh198xgl	756	7	also	also	RB
cord-259603-bh198xgl	756	8	shown	show	VBN
cord-259603-bh198xgl	756	9	to	to	TO
cord-259603-bh198xgl	756	10	have	have	VB
cord-259603-bh198xgl	756	11	profound	profound	JJ
cord-259603-bh198xgl	756	12	effects	effect	NNS
cord-259603-bh198xgl	756	13	on	on	IN
cord-259603-bh198xgl	756	14	viral	viral	JJ
cord-259603-bh198xgl	756	15	replication	replication	NN
cord-259603-bh198xgl	756	16	and	and	CC
cord-259603-bh198xgl	756	17	pathogenesis	pathogenesis	NN
cord-259603-bh198xgl	756	18	in	in	IN
cord-259603-bh198xgl	756	19	vivo	vivo	NN
cord-259603-bh198xgl	757	1	(	(	-LRB-
cord-259603-bh198xgl	757	2	Graham	Graham	NNP
cord-259603-bh198xgl	757	3	et	et	NNP
cord-259603-bh198xgl	757	4	al	al	NNP
cord-259603-bh198xgl	757	5	.	.	NNP
cord-259603-bh198xgl	757	6	,	,	,
cord-259603-bh198xgl	757	7	2012	2012	CD
cord-259603-bh198xgl	757	8	)	)	-RRB-
cord-259603-bh198xgl	757	9	.	.	.
cord-259603-bh198xgl	758	1	ExoN	exon	NN
cord-259603-bh198xgl	758	2	-	-	HYPH
cord-259603-bh198xgl	758	3	negative	negative	JJ
cord-259603-bh198xgl	758	4	mutants	mutant	NNS
cord-259603-bh198xgl	758	5	displayed	display	VBD
cord-259603-bh198xgl	758	6	a	a	DT
cord-259603-bh198xgl	758	7	stable	stable	JJ
cord-259603-bh198xgl	758	8	mutator	mutator	NN
cord-259603-bh198xgl	758	9	phenotype	phenotype	NN
cord-259603-bh198xgl	758	10	in	in	IN
cord-259603-bh198xgl	758	11	a	a	DT
cord-259603-bh198xgl	758	12	number	number	NN
cord-259603-bh198xgl	758	13	of	of	IN
cord-259603-bh198xgl	758	14	mouse	mouse	NN
cord-259603-bh198xgl	758	15	models	model	NNS
cord-259603-bh198xgl	758	16	of	of	IN
cord-259603-bh198xgl	758	17	human	human	JJ
cord-259603-bh198xgl	758	18	SARS	SARS	NNP
cord-259603-bh198xgl	758	19	,	,	,
cord-259603-bh198xgl	758	20	providing	provide	VBG
cord-259603-bh198xgl	758	21	a	a	DT
cord-259603-bh198xgl	758	22	promising	promising	JJ
cord-259603-bh198xgl	758	23	approach	approach	NN
cord-259603-bh198xgl	758	24	for	for	IN
cord-259603-bh198xgl	758	25	the	the	DT
cord-259603-bh198xgl	758	26	stable	stable	JJ
cord-259603-bh198xgl	758	27	attenuation	attenuation	NN
cord-259603-bh198xgl	758	28	of	of	IN
cord-259603-bh198xgl	758	29	highly	highly	RB
cord-259603-bh198xgl	758	30	pathogenic	pathogenic	JJ
cord-259603-bh198xgl	758	31	CoVs	covs	NN
cord-259603-bh198xgl	758	32	with	with	IN
cord-259603-bh198xgl	758	33	important	important	JJ
cord-259603-bh198xgl	758	34	implications	implication	NNS
cord-259603-bh198xgl	758	35	for	for	IN
cord-259603-bh198xgl	758	36	vaccine	vaccine	NN
cord-259603-bh198xgl	758	37	development	development	NN
cord-259603-bh198xgl	759	1	(	(	-LRB-
cord-259603-bh198xgl	759	2	Graham	Graham	NNP
cord-259603-bh198xgl	759	3	et	et	NNP
cord-259603-bh198xgl	759	4	al	al	NNP
cord-259603-bh198xgl	759	5	.	.	NNP
cord-259603-bh198xgl	759	6	,	,	,
cord-259603-bh198xgl	759	7	2012	2012	CD
cord-259603-bh198xgl	759	8	)	)	-RRB-
cord-259603-bh198xgl	759	9	.	.	.
cord-259603-bh198xgl	760	1	Coronavirus	Coronavirus	NNP
cord-259603-bh198xgl	760	2	nsp14	nsp14	NNP
cord-259603-bh198xgl	760	3	is	be	VBZ
cord-259603-bh198xgl	760	4	a	a	DT
cord-259603-bh198xgl	760	5	bifunctional	bifunctional	JJ
cord-259603-bh198xgl	760	6	protein	protein	NN
cord-259603-bh198xgl	760	7	comprised	comprise	VBN
cord-259603-bh198xgl	760	8	of	of	IN
cord-259603-bh198xgl	760	9	an	an	DT
cord-259603-bh198xgl	760	10	N	n	CD
cord-259603-bh198xgl	760	11	-	-	HYPH
cord-259603-bh198xgl	760	12	terminal	terminal	NN
cord-259603-bh198xgl	760	13	ExoN	ExoN	NNP
cord-259603-bh198xgl	760	14	domain	domain	NN
cord-259603-bh198xgl	760	15	and	and	CC
cord-259603-bh198xgl	760	16	a	a	DT
cord-259603-bh198xgl	760	17	C	c	NN
cord-259603-bh198xgl	760	18	-	-	HYPH
cord-259603-bh198xgl	760	19	terminal	terminal	NN
cord-259603-bh198xgl	760	20	N7-MTase	N7-MTase	NNP
cord-259603-bh198xgl	760	21	domain	domain	NN
cord-259603-bh198xgl	760	22	.	.	.
cord-259603-bh198xgl	761	1	Surprisingly	surprisingly	RB
cord-259603-bh198xgl	761	2	,	,	,
cord-259603-bh198xgl	761	3	the	the	DT
cord-259603-bh198xgl	761	4	latter	latter	JJ
cord-259603-bh198xgl	761	5	domain	domain	NN
cord-259603-bh198xgl	761	6	is	be	VBZ
cord-259603-bh198xgl	761	7	not	not	RB
cord-259603-bh198xgl	761	8	conserved	conserve	VBN
cord-259603-bh198xgl	761	9	in	in	IN
cord-259603-bh198xgl	761	10	the	the	DT
cord-259603-bh198xgl	761	11	Torovirinae	Torovirinae	NNP
cord-259603-bh198xgl	761	12	(	(	-LRB-
cord-259603-bh198xgl	761	13	genera	genera	DT
cord-259603-bh198xgl	761	14	Torovirus	Torovirus	NNP
cord-259603-bh198xgl	761	15	and	and	CC
cord-259603-bh198xgl	761	16	Bafinivirus	Bafinivirus	NNP
cord-259603-bh198xgl	761	17	)	)	-RRB-
cord-259603-bh198xgl	761	18	,	,	,
cord-259603-bh198xgl	761	19	representing	represent	VBG
cord-259603-bh198xgl	761	20	the	the	DT
cord-259603-bh198xgl	761	21	other	other	JJ
cord-259603-bh198xgl	761	22	subfamily	subfamily	NN
cord-259603-bh198xgl	761	23	of	of	IN
cord-259603-bh198xgl	761	24	the	the	DT
cord-259603-bh198xgl	761	25	Coronaviridae	Coronaviridae	NNP
cord-259603-bh198xgl	761	26	,	,	,
cord-259603-bh198xgl	761	27	but	but	CC
cord-259603-bh198xgl	761	28	in	in	IN
cord-259603-bh198xgl	761	29	other	other	JJ
cord-259603-bh198xgl	761	30	(	(	-LRB-
cord-259603-bh198xgl	761	31	more	more	RBR
cord-259603-bh198xgl	761	32	distantly	distantly	RB
cord-259603-bh198xgl	761	33	related	related	JJ
cord-259603-bh198xgl	761	34	)	)	-RRB-
cord-259603-bh198xgl	761	35	nidovirus	nidovirus	NN
cord-259603-bh198xgl	761	36	branches	branch	NNS
cord-259603-bh198xgl	761	37	(	(	-LRB-
cord-259603-bh198xgl	761	38	Lauber	Lauber	NNP
cord-259603-bh198xgl	761	39	et	et	NNP
cord-259603-bh198xgl	761	40	al	al	NNP
cord-259603-bh198xgl	761	41	.	.	NNP
cord-259603-bh198xgl	761	42	,	,	,
cord-259603-bh198xgl	761	43	2013	2013	CD
cord-259603-bh198xgl	761	44	;	;	:
cord-259603-bh198xgl	761	45	Nga	Nga	NNP
cord-259603-bh198xgl	761	46	et	et	NNP
cord-259603-bh198xgl	761	47	al	al	NNP
cord-259603-bh198xgl	761	48	.	.	NNP
cord-259603-bh198xgl	761	49	,	,	,
cord-259603-bh198xgl	761	50	2011	2011	CD
cord-259603-bh198xgl	761	51	)	)	-RRB-
cord-259603-bh198xgl	761	52	.	.	.
cord-259603-bh198xgl	762	1	This	this	DT
cord-259603-bh198xgl	762	2	conservation	conservation	NN
cord-259603-bh198xgl	762	3	pattern	pattern	NN
cord-259603-bh198xgl	762	4	suggests	suggest	VBZ
cord-259603-bh198xgl	762	5	that	that	IN
cord-259603-bh198xgl	762	6	a	a	DT
cord-259603-bh198xgl	762	7	common	common	JJ
cord-259603-bh198xgl	762	8	ancestor	ancestor	NN
cord-259603-bh198xgl	762	9	of	of	IN
cord-259603-bh198xgl	762	10	the	the	DT
cord-259603-bh198xgl	762	11	Corona-	Corona-	NNP
cord-259603-bh198xgl	762	12	,	,	,
cord-259603-bh198xgl	762	13	Mesoni-	Mesoni-	NNP
cord-259603-bh198xgl	762	14	,	,	,
cord-259603-bh198xgl	762	15	and	and	CC
cord-259603-bh198xgl	762	16	Roniviridae	Roniviridae	NNP
cord-259603-bh198xgl	762	17	contained	contain	VBD
cord-259603-bh198xgl	762	18	the	the	DT
cord-259603-bh198xgl	762	19	two	two	CD
cord-259603-bh198xgl	762	20	-	-	HYPH
cord-259603-bh198xgl	762	21	domain	domain	NN
cord-259603-bh198xgl	762	22	ExoN	ExoN	NNP
cord-259603-bh198xgl	762	23	/	/	SYM
cord-259603-bh198xgl	762	24	N7-MTase	N7-MTase	NNP
cord-259603-bh198xgl	762	25	structure	structure	NN
cord-259603-bh198xgl	762	26	while	while	IN
cord-259603-bh198xgl	762	27	some	some	DT
cord-259603-bh198xgl	762	28	lineages	lineage	NNS
cord-259603-bh198xgl	762	29	lost	lose	VBD
cord-259603-bh198xgl	762	30	the	the	DT
cord-259603-bh198xgl	762	31	N7-MTase	N7-MTase	NNP
cord-259603-bh198xgl	762	32	domain	domain	NN
cord-259603-bh198xgl	762	33	at	at	IN
cord-259603-bh198xgl	762	34	a	a	DT
cord-259603-bh198xgl	762	35	later	later	JJ
cord-259603-bh198xgl	762	36	stage	stage	NN
cord-259603-bh198xgl	762	37	.	.	.
cord-259603-bh198xgl	763	1	Although	although	IN
cord-259603-bh198xgl	763	2	nsp14	nsp14	NNP
cord-259603-bh198xgl	763	3	does	do	VBZ
cord-259603-bh198xgl	763	4	not	not	RB
cord-259603-bh198xgl	763	5	require	require	VB
cord-259603-bh198xgl	763	6	other	other	JJ
cord-259603-bh198xgl	763	7	proteins	protein	NNS
cord-259603-bh198xgl	763	8	for	for	IN
cord-259603-bh198xgl	763	9	activity	activity	NN
cord-259603-bh198xgl	763	10	Minskaia	Minskaia	NNP
cord-259603-bh198xgl	763	11	et	et	NNP
cord-259603-bh198xgl	763	12	al	al	NNP
cord-259603-bh198xgl	763	13	.	.	NNP
cord-259603-bh198xgl	763	14	,	,	,
cord-259603-bh198xgl	763	15	2006	2006	CD
cord-259603-bh198xgl	763	16	)	)	-RRB-
cord-259603-bh198xgl	763	17	,	,	,
cord-259603-bh198xgl	763	18	its	-PRON-	PRP$
cord-259603-bh198xgl	763	19	ribonucleolytic	ribonucleolytic	NN
cord-259603-bh198xgl	763	20	(	(	-LRB-
cord-259603-bh198xgl	763	21	but	but	CC
cord-259603-bh198xgl	763	22	not	not	RB
cord-259603-bh198xgl	763	23	the	the	DT
cord-259603-bh198xgl	763	24	N7-MTase	n7-mtase	NN
cord-259603-bh198xgl	763	25	)	)	-RRB-
cord-259603-bh198xgl	763	26	activity	activity	NN
cord-259603-bh198xgl	763	27	was	be	VBD
cord-259603-bh198xgl	763	28	shown	show	VBN
cord-259603-bh198xgl	763	29	to	to	TO
cord-259603-bh198xgl	763	30	be	be	VB
cord-259603-bh198xgl	763	31	stimulated	stimulate	VBN
cord-259603-bh198xgl	763	32	significantly	significantly	RB
cord-259603-bh198xgl	763	33	in	in	IN
cord-259603-bh198xgl	763	34	the	the	DT
cord-259603-bh198xgl	763	35	presence	presence	NN
cord-259603-bh198xgl	763	36	nsp10	nsp10	RB
cord-259603-bh198xgl	763	37	.	.	.
cord-259603-bh198xgl	764	1	In	in	IN
cord-259603-bh198xgl	764	2	line	line	NN
cord-259603-bh198xgl	764	3	with	with	IN
cord-259603-bh198xgl	764	4	this	this	DT
cord-259603-bh198xgl	764	5	,	,	,
cord-259603-bh198xgl	764	6	nsp10	nsp10	JJ
cord-259603-bh198xgl	764	7	variants	variant	NNS
cord-259603-bh198xgl	764	8	carrying	carry	VBG
cord-259603-bh198xgl	764	9	amino	amino	NN
cord-259603-bh198xgl	764	10	acid	acid	NN
cord-259603-bh198xgl	764	11	substitutions	substitution	NNS
cord-259603-bh198xgl	764	12	that	that	WDT
cord-259603-bh198xgl	764	13	prevent	prevent	VBP
cord-259603-bh198xgl	764	14	the	the	DT
cord-259603-bh198xgl	764	15	interaction	interaction	NN
cord-259603-bh198xgl	764	16	with	with	IN
cord-259603-bh198xgl	764	17	nsp14	nsp14	NNP
cord-259603-bh198xgl	764	18	failed	fail	VBD
cord-259603-bh198xgl	764	19	to	to	TO
cord-259603-bh198xgl	764	20	stimulate	stimulate	VB
cord-259603-bh198xgl	764	21	ExoN	ExoN	NNP
cord-259603-bh198xgl	764	22	activity	activity	NN
cord-259603-bh198xgl	764	23	(	(	-LRB-
cord-259603-bh198xgl	764	24	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	764	25	et	et	NNP
cord-259603-bh198xgl	764	26	al	al	NNP
cord-259603-bh198xgl	764	27	.	.	NNP
cord-259603-bh198xgl	764	28	,	,	,
cord-259603-bh198xgl	764	29	2012	2012	CD
cord-259603-bh198xgl	764	30	(	(	-LRB-
cord-259603-bh198xgl	764	31	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	764	32	et	et	NNP
cord-259603-bh198xgl	764	33	al	al	NNP
cord-259603-bh198xgl	764	34	.	.	NNP
cord-259603-bh198xgl	764	35	,	,	,
cord-259603-bh198xgl	764	36	,	,	,
cord-259603-bh198xgl	764	37	2014	2014	CD
cord-259603-bh198xgl	764	38	.	.	.
cord-259603-bh198xgl	765	1	To	to	IN
cord-259603-bh198xgl	765	2	date	date	NN
cord-259603-bh198xgl	765	3	,	,	,
cord-259603-bh198xgl	765	4	there	there	EX
cord-259603-bh198xgl	765	5	is	be	VBZ
cord-259603-bh198xgl	765	6	no	no	DT
cord-259603-bh198xgl	765	7	evidence	evidence	NN
cord-259603-bh198xgl	765	8	to	to	TO
cord-259603-bh198xgl	765	9	suggest	suggest	VB
cord-259603-bh198xgl	765	10	a	a	DT
cord-259603-bh198xgl	765	11	direct	direct	JJ
cord-259603-bh198xgl	765	12	role	role	NN
cord-259603-bh198xgl	765	13	for	for	IN
cord-259603-bh198xgl	765	14	nsp10	nsp10	NNPS
cord-259603-bh198xgl	765	15	in	in	IN
cord-259603-bh198xgl	765	16	catalysis	catalysis	NN
cord-259603-bh198xgl	765	17	.	.	.
cord-259603-bh198xgl	766	1	Most	most	RBS
cord-259603-bh198xgl	766	2	likely	likely	JJ
cord-259603-bh198xgl	766	3	,	,	,
cord-259603-bh198xgl	766	4	interactions	interaction	NNS
cord-259603-bh198xgl	766	5	between	between	IN
cord-259603-bh198xgl	766	6	the	the	DT
cord-259603-bh198xgl	766	7	nsp10	nsp10	NNPS
cord-259603-bh198xgl	766	8	and	and	CC
cord-259603-bh198xgl	766	9	the	the	DT
cord-259603-bh198xgl	766	10	N	n	CD
cord-259603-bh198xgl	766	11	-	-	HYPH
cord-259603-bh198xgl	766	12	terminal	terminal	NN
cord-259603-bh198xgl	766	13	domain	domain	NN
cord-259603-bh198xgl	766	14	of	of	IN
cord-259603-bh198xgl	766	15	nsp14	nsp14	TO
cord-259603-bh198xgl	766	16	stabilize	stabilize	VB
cord-259603-bh198xgl	766	17	the	the	DT
cord-259603-bh198xgl	766	18	ExoN	ExoN	NNP
cord-259603-bh198xgl	766	19	active	active	JJ
cord-259603-bh198xgl	766	20	site	site	NN
cord-259603-bh198xgl	766	21	in	in	IN
cord-259603-bh198xgl	766	22	a	a	DT
cord-259603-bh198xgl	766	23	catalytically	catalytically	RB
cord-259603-bh198xgl	766	24	competent	competent	JJ
cord-259603-bh198xgl	766	25	conformation	conformation	NN
cord-259603-bh198xgl	766	26	.	.	.
cord-259603-bh198xgl	767	1	Mutagenesis	Mutagenesis	NNP
cord-259603-bh198xgl	767	2	data	datum	NNS
cord-259603-bh198xgl	767	3	and	and	CC
cord-259603-bh198xgl	767	4	a	a	DT
cord-259603-bh198xgl	767	5	recent	recent	JJ
cord-259603-bh198xgl	767	6	X	x	NN
cord-259603-bh198xgl	767	7	-	-	NN
cord-259603-bh198xgl	767	8	ray	ray	NN
cord-259603-bh198xgl	767	9	structure	structure	NN
cord-259603-bh198xgl	767	10	analysis	analysis	NN
cord-259603-bh198xgl	767	11	of	of	IN
cord-259603-bh198xgl	767	12	a	a	DT
cord-259603-bh198xgl	767	13	SARS	SARS	NNP
cord-259603-bh198xgl	767	14	-	-	HYPH
cord-259603-bh198xgl	767	15	CoV	CoV	NNP
cord-259603-bh198xgl	768	1	nsp10	nsp10	NNP
cord-259603-bh198xgl	768	2	/	/	SYM
cord-259603-bh198xgl	768	3	nsp14	nsp14	CD
cord-259603-bh198xgl	768	4	complex	complex	NN
cord-259603-bh198xgl	769	1	(	(	-LRB-
cord-259603-bh198xgl	769	2	see	see	VB
cord-259603-bh198xgl	769	3	Fig	Fig	NNP
cord-259603-bh198xgl	769	4	.	.	.
cord-259603-bh198xgl	769	5	6	6	CD
cord-259603-bh198xgl	769	6	)	)	-RRB-
cord-259603-bh198xgl	769	7	revealed	reveal	VBD
cord-259603-bh198xgl	769	8	that	that	IN
cord-259603-bh198xgl	769	9	the	the	DT
cord-259603-bh198xgl	769	10	nsp10	nsp10	NNP
cord-259603-bh198xgl	769	11	surface	surface	NN
cord-259603-bh198xgl	769	12	required	require	VBN
cord-259603-bh198xgl	769	13	for	for	IN
cord-259603-bh198xgl	769	14	interaction	interaction	NN
cord-259603-bh198xgl	769	15	with	with	IN
cord-259603-bh198xgl	769	16	nsp14	nsp14	DT
cord-259603-bh198xgl	769	17	overlaps	overlap	VBZ
cord-259603-bh198xgl	769	18	with	with	IN
cord-259603-bh198xgl	769	19	the	the	DT
cord-259603-bh198xgl	769	20	surface	surface	NN
cord-259603-bh198xgl	769	21	involved	involve	VBN
cord-259603-bh198xgl	769	22	in	in	IN
cord-259603-bh198xgl	769	23	the	the	DT
cord-259603-bh198xgl	769	24	interaction	interaction	NN
cord-259603-bh198xgl	769	25	and	and	CC
cord-259603-bh198xgl	769	26	activation	activation	NN
cord-259603-bh198xgl	769	27	of	of	IN
cord-259603-bh198xgl	769	28	the	the	DT
cord-259603-bh198xgl	769	29	nsp16	nsp16	NNS
cord-259603-bh198xgl	769	30	2	2	CD
cord-259603-bh198xgl	769	31	0	0	CD
cord-259603-bh198xgl	769	32	-O	-o	CD
cord-259603-bh198xgl	769	33	-	-	HYPH
cord-259603-bh198xgl	769	34	MTase	mtase	JJ
cord-259603-bh198xgl	769	35	activity	activity	NN
cord-259603-bh198xgl	769	36	(	(	-LRB-
cord-259603-bh198xgl	769	37	see	see	VB
cord-259603-bh198xgl	769	38	earlier	early	RBR
cord-259603-bh198xgl	769	39	)	)	-RRB-
cord-259603-bh198xgl	770	1	(	(	-LRB-
cord-259603-bh198xgl	770	2	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	770	3	et	et	NNP
cord-259603-bh198xgl	770	4	al	al	NNP
cord-259603-bh198xgl	770	5	.	.	NNP
cord-259603-bh198xgl	770	6	,	,	,
cord-259603-bh198xgl	770	7	2014	2014	CD
cord-259603-bh198xgl	770	8	;	;	:
cord-259603-bh198xgl	770	9	Ma	Ma	NNP
cord-259603-bh198xgl	770	10	et	et	NNP
cord-259603-bh198xgl	770	11	al	al	NNP
cord-259603-bh198xgl	770	12	.	.	NNP
cord-259603-bh198xgl	770	13	,	,	,
cord-259603-bh198xgl	770	14	2015	2015	CD
cord-259603-bh198xgl	770	15	)	)	-RRB-
cord-259603-bh198xgl	770	16	.	.	.
cord-259603-bh198xgl	771	1	Coronavirus	Coronavirus	NNP
cord-259603-bh198xgl	771	2	ExoN	ExoN	NNP
cord-259603-bh198xgl	771	3	activities	activity	NNS
cord-259603-bh198xgl	771	4	were	be	VBD
cord-259603-bh198xgl	771	5	first	first	RB
cord-259603-bh198xgl	771	6	demonstrated	demonstrate	VBN
cord-259603-bh198xgl	771	7	using	use	VBG
cord-259603-bh198xgl	771	8	recombinant	recombinant	JJ
cord-259603-bh198xgl	771	9	forms	form	NNS
cord-259603-bh198xgl	771	10	of	of	IN
cord-259603-bh198xgl	771	11	SARS	SARS	NNP
cord-259603-bh198xgl	771	12	-	-	HYPH
cord-259603-bh198xgl	771	13	CoV	CoV	NNP
cord-259603-bh198xgl	771	14	nsp14	nsp14	NNP
cord-259603-bh198xgl	771	15	expressed	express	VBN
cord-259603-bh198xgl	771	16	in	in	IN
cord-259603-bh198xgl	771	17	E.	E.	NNP
cord-259603-bh198xgl	771	18	coli	coli	NNS
cord-259603-bh198xgl	771	19	(	(	-LRB-
cord-259603-bh198xgl	771	20	Minskaia	Minskaia	NNP
cord-259603-bh198xgl	771	21	et	et	NNP
cord-259603-bh198xgl	771	22	al	al	NNP
cord-259603-bh198xgl	771	23	.	.	NNP
cord-259603-bh198xgl	771	24	,	,	,
cord-259603-bh198xgl	771	25	2006	2006	CD
cord-259603-bh198xgl	771	26	)	)	-RRB-
cord-259603-bh198xgl	771	27	.	.	.
cord-259603-bh198xgl	772	1	The	the	DT
cord-259603-bh198xgl	772	2	protein	protein	NN
cord-259603-bh198xgl	772	3	was	be	VBD
cord-259603-bh198xgl	772	4	shown	show	VBN
cord-259603-bh198xgl	772	5	to	to	TO
cord-259603-bh198xgl	772	6	require	require	VB
cord-259603-bh198xgl	772	7	Mg	Mg	NNP
cord-259603-bh198xgl	772	8	2	2	CD
cord-259603-bh198xgl	772	9	+	+	SYM
cord-259603-bh198xgl	772	10	or	or	CC
cord-259603-bh198xgl	772	11	Mn	Mn	NNP
cord-259603-bh198xgl	772	12	2	2	CD
cord-259603-bh198xgl	772	13	+	+	SYM
cord-259603-bh198xgl	772	14	ions	ion	NNS
cord-259603-bh198xgl	772	15	for	for	IN
cord-259603-bh198xgl	772	16	activity	activity	NN
cord-259603-bh198xgl	772	17	and	and	CC
cord-259603-bh198xgl	772	18	to	to	TO
cord-259603-bh198xgl	772	19	degrade	degrade	VB
cord-259603-bh198xgl	772	20	a	a	DT
cord-259603-bh198xgl	772	21	range	range	NN
cord-259603-bh198xgl	772	22	of	of	IN
cord-259603-bh198xgl	772	23	single	single	RB
cord-259603-bh198xgl	772	24	-	-	HYPH
cord-259603-bh198xgl	772	25	stranded	stranded	JJ
cord-259603-bh198xgl	772	26	(	(	-LRB-
cord-259603-bh198xgl	772	27	ss	ss	NNP
cord-259603-bh198xgl	772	28	)	)	-RRB-
cord-259603-bh198xgl	772	29	synthetic	synthetic	JJ
cord-259603-bh198xgl	772	30	RNAs	rna	NNS
cord-259603-bh198xgl	772	31	with	with	IN
cord-259603-bh198xgl	772	32	3	3	CD
cord-259603-bh198xgl	772	33	0	0	CD
cord-259603-bh198xgl	772	34	-to-5	-to-5	NFP
cord-259603-bh198xgl	772	35	0	0	NFP
cord-259603-bh198xgl	772	36	directionality	directionality	NN
cord-259603-bh198xgl	772	37	to	to	TO
cord-259603-bh198xgl	772	38	yield	yield	VB
cord-259603-bh198xgl	772	39	reaction	reaction	NN
cord-259603-bh198xgl	772	40	products	product	NNS
cord-259603-bh198xgl	772	41	of	of	IN
cord-259603-bh198xgl	772	42	about	about	RB
cord-259603-bh198xgl	772	43	8	8	CD
cord-259603-bh198xgl	772	44	-	-	SYM
cord-259603-bh198xgl	772	45	12	12	CD
cord-259603-bh198xgl	772	46	nucleotides	nucleotide	NNS
cord-259603-bh198xgl	772	47	.	.	.
cord-259603-bh198xgl	773	1	The	the	DT
cord-259603-bh198xgl	773	2	data	datum	NNS
cord-259603-bh198xgl	773	3	further	further	RB
cord-259603-bh198xgl	773	4	suggested	suggest	VBD
cord-259603-bh198xgl	773	5	that	that	IN
cord-259603-bh198xgl	773	6	RNA	RNA	NNP
cord-259603-bh198xgl	773	7	secondary	secondary	JJ
cord-259603-bh198xgl	773	8	structure	structure	NN
cord-259603-bh198xgl	773	9	affects	affect	VBZ
cord-259603-bh198xgl	773	10	ExoN	ExoN	NNP
cord-259603-bh198xgl	773	11	activity	activity	NN
cord-259603-bh198xgl	773	12	(	(	-LRB-
cord-259603-bh198xgl	773	13	Minskaia	Minskaia	NNP
cord-259603-bh198xgl	773	14	et	et	NNP
cord-259603-bh198xgl	773	15	al	al	NNP
cord-259603-bh198xgl	773	16	.	.	NNP
cord-259603-bh198xgl	773	17	,	,	,
cord-259603-bh198xgl	773	18	2006	2006	CD
cord-259603-bh198xgl	773	19	)	)	-RRB-
cord-259603-bh198xgl	773	20	.	.	.
cord-259603-bh198xgl	774	1	Mutational	mutational	JJ
cord-259603-bh198xgl	774	2	analysis	analysis	NN
cord-259603-bh198xgl	774	3	of	of	IN
cord-259603-bh198xgl	774	4	predicted	predict	VBN
cord-259603-bh198xgl	774	5	active	active	JJ
cord-259603-bh198xgl	774	6	-	-	HYPH
cord-259603-bh198xgl	774	7	site	site	NN
cord-259603-bh198xgl	774	8	(	(	-LRB-
cord-259603-bh198xgl	774	9	Asp	Asp	NNP
cord-259603-bh198xgl	774	10	/	/	SYM
cord-259603-bh198xgl	774	11	Glu	Glu	NNP
cord-259603-bh198xgl	774	12	)	)	-RRB-
cord-259603-bh198xgl	774	13	residues	residue	NNS
cord-259603-bh198xgl	774	14	confirmed	confirm	VBD
cord-259603-bh198xgl	774	15	their	-PRON-	PRP$
cord-259603-bh198xgl	774	16	critical	critical	JJ
cord-259603-bh198xgl	774	17	involvement	involvement	NN
cord-259603-bh198xgl	774	18	in	in	IN
cord-259603-bh198xgl	774	19	catalysis	catalysis	NN
cord-259603-bh198xgl	774	20	(	(	-LRB-
cord-259603-bh198xgl	774	21	Minskaia	Minskaia	NNP
cord-259603-bh198xgl	774	22	et	et	NNP
cord-259603-bh198xgl	774	23	al	al	NNP
cord-259603-bh198xgl	774	24	.	.	NNP
cord-259603-bh198xgl	774	25	,	,	,
cord-259603-bh198xgl	774	26	2006	2006	CD
cord-259603-bh198xgl	774	27	)	)	-RRB-
cord-259603-bh198xgl	774	28	.	.	.
cord-259603-bh198xgl	775	1	In	in	IN
cord-259603-bh198xgl	775	2	a	a	DT
cord-259603-bh198xgl	775	3	subsequent	subsequent	JJ
cord-259603-bh198xgl	775	4	study	study	NN
cord-259603-bh198xgl	775	5	,	,	,
cord-259603-bh198xgl	775	6	using	use	VBG
cord-259603-bh198xgl	775	7	nsp10	nsp10	NNPS
cord-259603-bh198xgl	775	8	/	/	SYM
cord-259603-bh198xgl	775	9	nsp14	nsp14	CD
cord-259603-bh198xgl	775	10	complexes	complex	NNS
cord-259603-bh198xgl	775	11	,	,	,
cord-259603-bh198xgl	775	12	the	the	DT
cord-259603-bh198xgl	775	13	substrate	substrate	NN
cord-259603-bh198xgl	775	14	specificity	specificity	NN
cord-259603-bh198xgl	775	15	was	be	VBD
cord-259603-bh198xgl	775	16	characterized	characterize	VBN
cord-259603-bh198xgl	775	17	in	in	IN
cord-259603-bh198xgl	775	18	more	more	JJR
cord-259603-bh198xgl	775	19	detail	detail	NN
cord-259603-bh198xgl	775	20	and	and	CC
cord-259603-bh198xgl	775	21	revealed	reveal	VBD
cord-259603-bh198xgl	775	22	dsRNA	dsrna	NN
cord-259603-bh198xgl	775	23	with	with	IN
cord-259603-bh198xgl	775	24	a	a	DT
cord-259603-bh198xgl	775	25	terminal	terminal	JJ
cord-259603-bh198xgl	775	26	mismatch	mismatch	NN
cord-259603-bh198xgl	775	27	to	to	TO
cord-259603-bh198xgl	775	28	be	be	VB
cord-259603-bh198xgl	775	29	the	the	DT
cord-259603-bh198xgl	775	30	preferred	preferred	JJ
cord-259603-bh198xgl	775	31	substrate	substrate	NN
cord-259603-bh198xgl	775	32	for	for	IN
cord-259603-bh198xgl	775	33	ExoN	ExoN	NNP
cord-259603-bh198xgl	775	34	activity	activity	NN
cord-259603-bh198xgl	775	35	.	.	.
cord-259603-bh198xgl	776	1	Excision	excision	NN
cord-259603-bh198xgl	776	2	efficiencies	efficiency	NNS
cord-259603-bh198xgl	776	3	using	use	VBG
cord-259603-bh198xgl	776	4	different	different	JJ
cord-259603-bh198xgl	776	5	mismatched	mismatch	VBN
cord-259603-bh198xgl	776	6	base	base	NN
cord-259603-bh198xgl	776	7	pairs	pair	NNS
cord-259603-bh198xgl	776	8	(	(	-LRB-
cord-259603-bh198xgl	776	9	A	a	NN
cord-259603-bh198xgl	776	10	:	:	:
cord-259603-bh198xgl	776	11	G	g	NN
cord-259603-bh198xgl	776	12	,	,	,
cord-259603-bh198xgl	776	13	A	a	NN
cord-259603-bh198xgl	776	14	:	:	:
cord-259603-bh198xgl	776	15	A	a	NN
cord-259603-bh198xgl	776	16	,	,	,
cord-259603-bh198xgl	776	17	A	a	NN
cord-259603-bh198xgl	776	18	:	:	:
cord-259603-bh198xgl	776	19	C	c	NN
cord-259603-bh198xgl	776	20	,	,	,
cord-259603-bh198xgl	776	21	U	u	NN
cord-259603-bh198xgl	776	22	:	:	:
cord-259603-bh198xgl	776	23	G	g	NN
cord-259603-bh198xgl	776	24	,	,	,
cord-259603-bh198xgl	776	25	U	u	NN
cord-259603-bh198xgl	776	26	:	:	:
cord-259603-bh198xgl	776	27	C	C	NNP
cord-259603-bh198xgl	776	28	,	,	,
cord-259603-bh198xgl	776	29	U	u	NN
cord-259603-bh198xgl	776	30	:	:	:
cord-259603-bh198xgl	776	31	U	U	NNP
cord-259603-bh198xgl	776	32	)	)	-RRB-
cord-259603-bh198xgl	776	33	were	be	VBD
cord-259603-bh198xgl	776	34	found	find	VBN
cord-259603-bh198xgl	776	35	to	to	TO
cord-259603-bh198xgl	776	36	be	be	VB
cord-259603-bh198xgl	776	37	similar	similar	JJ
cord-259603-bh198xgl	776	38	,	,	,
cord-259603-bh198xgl	776	39	suggesting	suggest	VBG
cord-259603-bh198xgl	776	40	that	that	IN
cord-259603-bh198xgl	776	41	the	the	DT
cord-259603-bh198xgl	776	42	mismatch	mismatch	NN
cord-259603-bh198xgl	776	43	rather	rather	RB
cord-259603-bh198xgl	776	44	than	than	IN
cord-259603-bh198xgl	776	45	the	the	DT
cord-259603-bh198xgl	776	46	nature	nature	NN
cord-259603-bh198xgl	776	47	of	of	IN
cord-259603-bh198xgl	776	48	the	the	DT
cord-259603-bh198xgl	776	49	nucleotide	nucleotide	NN
cord-259603-bh198xgl	776	50	misincorporated	misincorporate	VBN
cord-259603-bh198xgl	776	51	at	at	IN
cord-259603-bh198xgl	776	52	the	the	DT
cord-259603-bh198xgl	776	53	3	3	CD
cord-259603-bh198xgl	776	54	0	0	CD
cord-259603-bh198xgl	776	55	end	end	NN
cord-259603-bh198xgl	776	56	determines	determine	VBZ
cord-259603-bh198xgl	776	57	ExoN	ExoN	NNP
cord-259603-bh198xgl	776	58	activity	activity	NN
cord-259603-bh198xgl	776	59	(	(	-LRB-
cord-259603-bh198xgl	776	60	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	776	61	et	et	NNP
cord-259603-bh198xgl	776	62	al	al	NNP
cord-259603-bh198xgl	776	63	.	.	NNP
cord-259603-bh198xgl	776	64	,	,	,
cord-259603-bh198xgl	776	65	2012	2012	CD
cord-259603-bh198xgl	776	66	)	)	-RRB-
cord-259603-bh198xgl	776	67	.	.	.
cord-259603-bh198xgl	777	1	In	in	IN
cord-259603-bh198xgl	777	2	a	a	DT
cord-259603-bh198xgl	777	3	recent	recent	JJ
cord-259603-bh198xgl	777	4	study	study	NN
cord-259603-bh198xgl	777	5	,	,	,
cord-259603-bh198xgl	777	6	the	the	DT
cord-259603-bh198xgl	777	7	structures	structure	NNS
cord-259603-bh198xgl	777	8	of	of	IN
cord-259603-bh198xgl	777	9	unliganded	unligande	VBN
cord-259603-bh198xgl	777	10	,	,	,
cord-259603-bh198xgl	777	11	SAM	SAM	NNP
cord-259603-bh198xgl	777	12	-	-	HYPH
cord-259603-bh198xgl	777	13	bound	bind	VBN
cord-259603-bh198xgl	777	14	,	,	,
cord-259603-bh198xgl	777	15	and	and	CC
cord-259603-bh198xgl	777	16	SAH	SAH	NNP
cord-259603-bh198xgl	777	17	-	-	HYPH
cord-259603-bh198xgl	777	18	GpppA	GpppA	NNP
cord-259603-bh198xgl	777	19	-	-	HYPH
cord-259603-bh198xgl	777	20	bound	bind	VBN
cord-259603-bh198xgl	778	1	SARS	SARS	NNP
cord-259603-bh198xgl	778	2	-	-	HYPH
cord-259603-bh198xgl	778	3	CoV	CoV	NNP
cord-259603-bh198xgl	778	4	nsp10-nsp14	nsp10-nsp14	JJ
cord-259603-bh198xgl	778	5	complexes	complex	NNS
cord-259603-bh198xgl	778	6	were	be	VBD
cord-259603-bh198xgl	778	7	determined	determine	VBN
cord-259603-bh198xgl	778	8	by	by	IN
cord-259603-bh198xgl	778	9	X	x	NN
cord-259603-bh198xgl	778	10	-	-	NN
cord-259603-bh198xgl	778	11	ray	ray	NN
cord-259603-bh198xgl	778	12	crystallography	crystallography	NN
cord-259603-bh198xgl	778	13	(	(	-LRB-
cord-259603-bh198xgl	778	14	Ma	Ma	NNP
cord-259603-bh198xgl	778	15	et	et	FW
cord-259603-bh198xgl	778	16	al	al	NNP
cord-259603-bh198xgl	778	17	.	.	NNP
cord-259603-bh198xgl	778	18	,	,	,
cord-259603-bh198xgl	778	19	2015	2015	CD
cord-259603-bh198xgl	778	20	)	)	-RRB-
cord-259603-bh198xgl	778	21	.	.	.
cord-259603-bh198xgl	779	1	The	the	DT
cord-259603-bh198xgl	779	2	structures	structure	NNS
cord-259603-bh198xgl	779	3	provide	provide	VBP
cord-259603-bh198xgl	779	4	important	important	JJ
cord-259603-bh198xgl	779	5	insight	insight	NN
cord-259603-bh198xgl	779	6	into	into	IN
cord-259603-bh198xgl	779	7	the	the	DT
cord-259603-bh198xgl	779	8	two	two	CD
cord-259603-bh198xgl	779	9	-	-	HYPH
cord-259603-bh198xgl	779	10	subdomain	subdomain	NN
cord-259603-bh198xgl	779	11	structure	structure	NN
cord-259603-bh198xgl	779	12	of	of	IN
cord-259603-bh198xgl	779	13	nsp14	nsp14	NNP
cord-259603-bh198xgl	779	14	,	,	,
cord-259603-bh198xgl	779	15	the	the	DT
cord-259603-bh198xgl	779	16	two	two	CD
cord-259603-bh198xgl	779	17	catalytic	catalytic	JJ
cord-259603-bh198xgl	779	18	sites	site	NNS
cord-259603-bh198xgl	779	19	of	of	IN
cord-259603-bh198xgl	779	20	ExoN	ExoN	NNP
cord-259603-bh198xgl	779	21	and	and	CC
cord-259603-bh198xgl	779	22	N7-MTase	N7-MTase	NNP
cord-259603-bh198xgl	779	23	,	,	,
cord-259603-bh198xgl	779	24	critical	critical	JJ
cord-259603-bh198xgl	779	25	substrate	substrate	NN
cord-259603-bh198xgl	779	26	-	-	HYPH
cord-259603-bh198xgl	779	27	binding	bind	VBG
cord-259603-bh198xgl	779	28	residues	residue	NNS
cord-259603-bh198xgl	779	29	,	,	,
cord-259603-bh198xgl	779	30	the	the	DT
cord-259603-bh198xgl	779	31	contribution	contribution	NN
cord-259603-bh198xgl	779	32	of	of	IN
cord-259603-bh198xgl	779	33	nsp10	nsp10	RB
cord-259603-bh198xgl	779	34	to	to	IN
cord-259603-bh198xgl	779	35	enhancing	enhance	VBG
cord-259603-bh198xgl	779	36	ExoN	ExoN	NNP
cord-259603-bh198xgl	779	37	activity	activity	NN
cord-259603-bh198xgl	779	38	,	,	,
cord-259603-bh198xgl	779	39	and	and	CC
cord-259603-bh198xgl	779	40	the	the	DT
cord-259603-bh198xgl	779	41	roles	role	NNS
cord-259603-bh198xgl	779	42	of	of	IN
cord-259603-bh198xgl	779	43	as	as	RB
cord-259603-bh198xgl	779	44	many	many	JJ
cord-259603-bh198xgl	779	45	as	as	IN
cord-259603-bh198xgl	779	46	three	three	CD
cord-259603-bh198xgl	779	47	zinc	zinc	NN
cord-259603-bh198xgl	779	48	fingers	finger	NNS
cord-259603-bh198xgl	779	49	present	present	JJ
cord-259603-bh198xgl	779	50	in	in	IN
cord-259603-bh198xgl	779	51	nsp14	nsp14	XX
cord-259603-bh198xgl	780	1	(	(	-LRB-
cord-259603-bh198xgl	780	2	Fig	Fig	NNP
cord-259603-bh198xgl	780	3	.	.	.
cord-259603-bh198xgl	780	4	6	6	CD
cord-259603-bh198xgl	780	5	)	)	-RRB-
cord-259603-bh198xgl	780	6	.	.	.
cord-259603-bh198xgl	781	1	In	in	IN
cord-259603-bh198xgl	781	2	the	the	DT
cord-259603-bh198xgl	781	3	structure	structure	NN
cord-259603-bh198xgl	781	4	,	,	,
cord-259603-bh198xgl	781	5	one	one	CD
cord-259603-bh198xgl	781	6	molecule	molecule	NN
cord-259603-bh198xgl	781	7	of	of	IN
cord-259603-bh198xgl	781	8	nsp14	nsp14	NNP
cord-259603-bh198xgl	781	9	was	be	VBD
cord-259603-bh198xgl	781	10	found	find	VBN
cord-259603-bh198xgl	781	11	to	to	TO
cord-259603-bh198xgl	781	12	bind	bind	VB
cord-259603-bh198xgl	781	13	one	one	CD
cord-259603-bh198xgl	781	14	molecule	molecule	NN
cord-259603-bh198xgl	781	15	of	of	IN
cord-259603-bh198xgl	781	16	nsp10	nsp10	PRP
cord-259603-bh198xgl	781	17	.	.	.
cord-259603-bh198xgl	782	1	Given	give	VBN
cord-259603-bh198xgl	782	2	that	that	IN
cord-259603-bh198xgl	782	3	nsp10	nsp10	RB
cord-259603-bh198xgl	782	4	tends	tend	VBZ
cord-259603-bh198xgl	782	5	to	to	TO
cord-259603-bh198xgl	782	6	form	form	VB
cord-259603-bh198xgl	782	7	multimers	multimer	NNS
cord-259603-bh198xgl	782	8	,	,	,
cord-259603-bh198xgl	782	9	it	-PRON-	PRP
cord-259603-bh198xgl	782	10	is	be	VBZ
cord-259603-bh198xgl	782	11	tempting	tempt	VBG
cord-259603-bh198xgl	782	12	to	to	TO
cord-259603-bh198xgl	782	13	speculate	speculate	VB
cord-259603-bh198xgl	782	14	that	that	IN
cord-259603-bh198xgl	782	15	,	,	,
cord-259603-bh198xgl	782	16	in	in	IN
cord-259603-bh198xgl	782	17	infected	infected	JJ
cord-259603-bh198xgl	782	18	cells	cell	NNS
cord-259603-bh198xgl	782	19	,	,	,
cord-259603-bh198xgl	782	20	the	the	DT
cord-259603-bh198xgl	782	21	nsp10-nsp14	nsp10-nsp14	JJ
cord-259603-bh198xgl	782	22	complex	complex	NN
cord-259603-bh198xgl	782	23	may	may	MD
cord-259603-bh198xgl	782	24	form	form	VB
cord-259603-bh198xgl	782	25	even	even	RB
cord-259603-bh198xgl	782	26	larger	large	JJR
cord-259603-bh198xgl	782	27	complexes	complex	NNS
cord-259603-bh198xgl	782	28	,	,	,
cord-259603-bh198xgl	782	29	for	for	IN
cord-259603-bh198xgl	782	30	example	example	NN
cord-259603-bh198xgl	782	31	,	,	,
cord-259603-bh198xgl	782	32	by	by	IN
cord-259603-bh198xgl	782	33	interacting	interact	VBG
cord-259603-bh198xgl	782	34	with	with	IN
cord-259603-bh198xgl	782	35	nsp10-nsp16	nsp10-nsp16	CD
cord-259603-bh198xgl	782	36	complexes	complex	NNS
cord-259603-bh198xgl	782	37	that	that	WDT
cord-259603-bh198xgl	782	38	might	may	MD
cord-259603-bh198xgl	782	39	be	be	VB
cord-259603-bh198xgl	782	40	stabilized	stabilize	VBN
cord-259603-bh198xgl	782	41	by	by	IN
cord-259603-bh198xgl	782	42	nsp10-nsp10	nsp10-nsp10	NNP
cord-259603-bh198xgl	782	43	interactions	interaction	NNS
cord-259603-bh198xgl	782	44	.	.	.
cord-259603-bh198xgl	783	1	In	in	IN
cord-259603-bh198xgl	783	2	this	this	DT
cord-259603-bh198xgl	783	3	way	way	NN
cord-259603-bh198xgl	783	4	,	,	,
cord-259603-bh198xgl	783	5	consecutive	consecutive	JJ
cord-259603-bh198xgl	783	6	methylation	methylation	NN
cord-259603-bh198xgl	783	7	reactions	reaction	NNS
cord-259603-bh198xgl	783	8	of	of	IN
cord-259603-bh198xgl	783	9	the	the	DT
cord-259603-bh198xgl	783	10	5	5	CD
cord-259603-bh198xgl	783	11	0	0	CD
cord-259603-bh198xgl	783	12	cap	cap	NN
cord-259603-bh198xgl	783	13	structure	structure	NN
cord-259603-bh198xgl	783	14	could	could	MD
cord-259603-bh198xgl	783	15	be	be	VB
cord-259603-bh198xgl	783	16	spatially	spatially	RB
cord-259603-bh198xgl	783	17	coordinated	coordinate	VBN
cord-259603-bh198xgl	783	18	.	.	.
cord-259603-bh198xgl	784	1	Comparison	comparison	NN
cord-259603-bh198xgl	784	2	of	of	IN
cord-259603-bh198xgl	784	3	the	the	DT
cord-259603-bh198xgl	784	4	nsp10	nsp10	JJ
cord-259603-bh198xgl	784	5	surfaces	surface	NNS
cord-259603-bh198xgl	784	6	that	that	WDT
cord-259603-bh198xgl	784	7	interact	interact	VBP
cord-259603-bh198xgl	784	8	with	with	IN
cord-259603-bh198xgl	784	9	nsp14	nsp14	NN
cord-259603-bh198xgl	784	10	and	and	CC
cord-259603-bh198xgl	784	11	nsp16	nsp16	NNS
cord-259603-bh198xgl	784	12	,	,	,
cord-259603-bh198xgl	784	13	respectively	respectively	RB
cord-259603-bh198xgl	784	14	,	,	,
cord-259603-bh198xgl	784	15	revealed	reveal	VBD
cord-259603-bh198xgl	784	16	a	a	DT
cord-259603-bh198xgl	784	17	significant	significant	JJ
cord-259603-bh198xgl	784	18	overlap	overlap	NN
cord-259603-bh198xgl	784	19	(	(	-LRB-
cord-259603-bh198xgl	784	20	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	784	21	et	et	NNP
cord-259603-bh198xgl	784	22	al	al	NNP
cord-259603-bh198xgl	784	23	.	.	NNP
cord-259603-bh198xgl	784	24	,	,	,
cord-259603-bh198xgl	784	25	2014	2014	CD
cord-259603-bh198xgl	784	26	)	)	-RRB-
cord-259603-bh198xgl	784	27	,	,	,
cord-259603-bh198xgl	784	28	with	with	IN
cord-259603-bh198xgl	784	29	a	a	DT
cord-259603-bh198xgl	784	30	substantially	substantially	RB
cord-259603-bh198xgl	784	31	larger	large	JJR
cord-259603-bh198xgl	784	32	surface	surface	NN
cord-259603-bh198xgl	784	33	being	be	VBG
cord-259603-bh198xgl	784	34	involved	involve	VBN
cord-259603-bh198xgl	784	35	in	in	IN
cord-259603-bh198xgl	784	36	interactions	interaction	NNS
cord-259603-bh198xgl	784	37	between	between	IN
cord-259603-bh198xgl	784	38	nsp10	nsp10	PRP
cord-259603-bh198xgl	784	39	and	and	CC
cord-259603-bh198xgl	784	40	nsp14	nsp14	NNP
cord-259603-bh198xgl	784	41	.	.	.
cord-259603-bh198xgl	785	1	Buried	bury	VBN
cord-259603-bh198xgl	785	2	solvent	solvent	NN
cord-259603-bh198xgl	785	3	accessible	accessible	JJ
cord-259603-bh198xgl	785	4	areas	area	NNS
cord-259603-bh198xgl	785	5	for	for	IN
cord-259603-bh198xgl	785	6	interactions	interaction	NNS
cord-259603-bh198xgl	785	7	with	with	IN
cord-259603-bh198xgl	785	8	nsp14	nsp14	NN
cord-259603-bh198xgl	785	9	and	and	CC
cord-259603-bh198xgl	785	10	nsp16	nsp16	NNS
cord-259603-bh198xgl	785	11	were	be	VBD
cord-259603-bh198xgl	785	12	determined	determine	VBN
cord-259603-bh198xgl	785	13	to	to	TO
cord-259603-bh198xgl	785	14	be	be	VB
cord-259603-bh198xgl	785	15	2236	2236	CD
cord-259603-bh198xgl	785	16	and	and	CC
cord-259603-bh198xgl	785	17	938	938	CD
cord-259603-bh198xgl	785	18	Å	å	NN
cord-259603-bh198xgl	785	19	2	2	CD
cord-259603-bh198xgl	785	20	,	,	,
cord-259603-bh198xgl	786	1	respectively	respectively	RB
cord-259603-bh198xgl	786	2	(	(	-LRB-
cord-259603-bh198xgl	786	3	Decroly	Decroly	NNP
cord-259603-bh198xgl	786	4	et	et	NNP
cord-259603-bh198xgl	786	5	al	al	NNP
cord-259603-bh198xgl	786	6	.	.	NNP
cord-259603-bh198xgl	786	7	,	,	,
cord-259603-bh198xgl	786	8	2011	2011	CD
cord-259603-bh198xgl	787	1	;	;	:
cord-259603-bh198xgl	787	2	Ma	Ma	NNP
cord-259603-bh198xgl	787	3	et	et	NNP
cord-259603-bh198xgl	787	4	al	al	NNP
cord-259603-bh198xgl	787	5	.	.	NNP
cord-259603-bh198xgl	787	6	,	,	,
cord-259603-bh198xgl	787	7	2015	2015	CD
cord-259603-bh198xgl	787	8	)	)	-RRB-
cord-259603-bh198xgl	787	9	.	.	.
cord-259603-bh198xgl	788	1	The	the	DT
cord-259603-bh198xgl	788	2	structure	structure	NN
cord-259603-bh198xgl	788	3	of	of	IN
cord-259603-bh198xgl	788	4	the	the	DT
cord-259603-bh198xgl	788	5	nsp10-nsp14	nsp10-nsp14	NNP
cord-259603-bh198xgl	788	6	complex	complex	NN
cord-259603-bh198xgl	788	7	also	also	RB
cord-259603-bh198xgl	788	8	helps	help	VBZ
cord-259603-bh198xgl	788	9	to	to	TO
cord-259603-bh198xgl	788	10	explain	explain	VB
cord-259603-bh198xgl	788	11	the	the	DT
cord-259603-bh198xgl	788	12	observed	observed	JJ
cord-259603-bh198xgl	788	13	stimulation	stimulation	NN
cord-259603-bh198xgl	788	14	of	of	IN
cord-259603-bh198xgl	788	15	ExoN	ExoN	NNP
cord-259603-bh198xgl	788	16	activity	activity	NN
cord-259603-bh198xgl	788	17	by	by	IN
cord-259603-bh198xgl	788	18	nsp10	nsp10	NNPS
cord-259603-bh198xgl	788	19	(	(	-LRB-
cord-259603-bh198xgl	788	20	see	see	VB
cord-259603-bh198xgl	788	21	earlier	early	RBR
cord-259603-bh198xgl	788	22	)	)	-RRB-
cord-259603-bh198xgl	788	23	.	.	.
cord-259603-bh198xgl	789	1	Two	two	CD
cord-259603-bh198xgl	789	2	regions	region	NNS
cord-259603-bh198xgl	789	3	of	of	IN
cord-259603-bh198xgl	789	4	nsp10	nsp10	NNPS
cord-259603-bh198xgl	789	5	interact	interact	VBP
cord-259603-bh198xgl	789	6	extensively	extensively	RB
cord-259603-bh198xgl	789	7	with	with	IN
cord-259603-bh198xgl	789	8	different	different	JJ
cord-259603-bh198xgl	789	9	structural	structural	JJ
cord-259603-bh198xgl	789	10	elements	element	NNS
cord-259603-bh198xgl	789	11	of	of	IN
cord-259603-bh198xgl	789	12	the	the	DT
cord-259603-bh198xgl	789	13	nsp14	nsp14	NNP
cord-259603-bh198xgl	789	14	N	n	CD
cord-259603-bh198xgl	789	15	-	-	HYPH
cord-259603-bh198xgl	789	16	terminal	terminal	NN
cord-259603-bh198xgl	789	17	domain	domain	NN
cord-259603-bh198xgl	789	18	,	,	,
cord-259603-bh198xgl	789	19	most	most	RBS
cord-259603-bh198xgl	789	20	likely	likely	JJ
cord-259603-bh198xgl	789	21	to	to	TO
cord-259603-bh198xgl	789	22	maintain	maintain	VB
cord-259603-bh198xgl	789	23	the	the	DT
cord-259603-bh198xgl	789	24	structural	structural	JJ
cord-259603-bh198xgl	789	25	integrity	integrity	NN
cord-259603-bh198xgl	789	26	of	of	IN
cord-259603-bh198xgl	789	27	the	the	DT
cord-259603-bh198xgl	789	28	ExoN	ExoN	NNP
cord-259603-bh198xgl	789	29	domain	domain	NN
cord-259603-bh198xgl	789	30	.	.	.
cord-259603-bh198xgl	790	1	Interestingly	interestingly	RB
cord-259603-bh198xgl	790	2	,	,	,
cord-259603-bh198xgl	790	3	the	the	DT
cord-259603-bh198xgl	790	4	observed	observed	JJ
cord-259603-bh198xgl	790	5	interaction	interaction	NN
cord-259603-bh198xgl	790	6	of	of	IN
cord-259603-bh198xgl	790	7	N	n	CD
cord-259603-bh198xgl	790	8	-	-	HYPH
cord-259603-bh198xgl	790	9	terminal	terminal	NN
cord-259603-bh198xgl	790	10	residues	residue	NNS
cord-259603-bh198xgl	790	11	of	of	IN
cord-259603-bh198xgl	790	12	nsp10	nsp10	PRP
cord-259603-bh198xgl	790	13	with	with	IN
cord-259603-bh198xgl	790	14	nsp14	nsp14	NNP
cord-259603-bh198xgl	790	15	led	lead	VBD
cord-259603-bh198xgl	790	16	to	to	IN
cord-259603-bh198xgl	790	17	interpretable	interpretable	JJ
cord-259603-bh198xgl	790	18	electron	electron	NN
cord-259603-bh198xgl	790	19	density	density	NN
cord-259603-bh198xgl	790	20	for	for	IN
cord-259603-bh198xgl	790	21	these	these	DT
cord-259603-bh198xgl	790	22	residues	residue	NNS
cord-259603-bh198xgl	790	23	that	that	WDT
cord-259603-bh198xgl	790	24	had	have	VBD
cord-259603-bh198xgl	790	25	not	not	RB
cord-259603-bh198xgl	790	26	been	be	VBN
cord-259603-bh198xgl	790	27	observed	observe	VBN
cord-259603-bh198xgl	790	28	in	in	IN
cord-259603-bh198xgl	790	29	previous	previous	JJ
cord-259603-bh198xgl	790	30	structures	structure	NNS
cord-259603-bh198xgl	790	31	of	of	IN
cord-259603-bh198xgl	790	32	nsp10	nsp10	XX
cord-259603-bh198xgl	791	1	(	(	-LRB-
cord-259603-bh198xgl	791	2	Joseph	Joseph	NNP
cord-259603-bh198xgl	791	3	et	et	NNP
cord-259603-bh198xgl	791	4	al	al	NNP
cord-259603-bh198xgl	791	5	.	.	NNP
cord-259603-bh198xgl	791	6	,	,	,
cord-259603-bh198xgl	791	7	2007	2007	CD
cord-259603-bh198xgl	792	1	;	;	:
cord-259603-bh198xgl	792	2	Su	Su	NNP
cord-259603-bh198xgl	792	3	et	et	FW
cord-259603-bh198xgl	792	4	al	al	NNP
cord-259603-bh198xgl	792	5	.	.	NNP
cord-259603-bh198xgl	792	6	,	,	,
cord-259603-bh198xgl	792	7	2006	2006	CD
cord-259603-bh198xgl	792	8	)	)	-RRB-
cord-259603-bh198xgl	792	9	or	or	CC
cord-259603-bh198xgl	792	10	the	the	DT
cord-259603-bh198xgl	792	11	nsp10-nsp16	nsp10-nsp16	CD
cord-259603-bh198xgl	792	12	complex	complex	NN
cord-259603-bh198xgl	792	13	(	(	-LRB-
cord-259603-bh198xgl	792	14	Chen	Chen	NNP
cord-259603-bh198xgl	792	15	et	et	NNP
cord-259603-bh198xgl	792	16	al	al	NNP
cord-259603-bh198xgl	792	17	.	.	NNP
cord-259603-bh198xgl	792	18	,	,	,
cord-259603-bh198xgl	792	19	2011	2011	CD
cord-259603-bh198xgl	792	20	;	;	:
cord-259603-bh198xgl	793	1	Decroly	Decroly	NNP
cord-259603-bh198xgl	793	2	et	et	NNP
cord-259603-bh198xgl	793	3	al	al	NNP
cord-259603-bh198xgl	793	4	.	.	NNP
cord-259603-bh198xgl	793	5	,	,	,
cord-259603-bh198xgl	793	6	2011	2011	CD
cord-259603-bh198xgl	793	7	)	)	-RRB-
cord-259603-bh198xgl	793	8	,	,	,
cord-259603-bh198xgl	793	9	consistent	consistent	JJ
cord-259603-bh198xgl	793	10	with	with	IN
cord-259603-bh198xgl	793	11	the	the	DT
cord-259603-bh198xgl	793	12	proposed	propose	VBN
cord-259603-bh198xgl	793	13	role	role	NN
cord-259603-bh198xgl	793	14	of	of	IN
cord-259603-bh198xgl	793	15	the	the	DT
cord-259603-bh198xgl	793	16	N	n	CD
cord-259603-bh198xgl	793	17	-	-	HYPH
cord-259603-bh198xgl	793	18	terminal	terminal	JJ
cord-259603-bh198xgl	793	19	loop	loop	NN
cord-259603-bh198xgl	793	20	of	of	IN
cord-259603-bh198xgl	793	21	nsp10	nsp10	PRP
cord-259603-bh198xgl	793	22	in	in	IN
cord-259603-bh198xgl	793	23	stabilizing	stabilize	VBG
cord-259603-bh198xgl	793	24	interactions	interaction	NNS
cord-259603-bh198xgl	793	25	with	with	IN
cord-259603-bh198xgl	793	26	nsp14	nsp14	XX
cord-259603-bh198xgl	793	27	.	.	.
cord-259603-bh198xgl	794	1	The	the	DT
cord-259603-bh198xgl	794	2	structure	structure	NN
cord-259603-bh198xgl	794	3	of	of	IN
cord-259603-bh198xgl	794	4	the	the	DT
cord-259603-bh198xgl	794	5	ExoN	ExoN	NNP
cord-259603-bh198xgl	794	6	domain	domain	NN
cord-259603-bh198xgl	794	7	is	be	VBZ
cord-259603-bh198xgl	794	8	essentially	essentially	RB
cord-259603-bh198xgl	794	9	comprised	comprise	VBN
cord-259603-bh198xgl	794	10	of	of	IN
cord-259603-bh198xgl	794	11	a	a	DT
cord-259603-bh198xgl	794	12	twisted	twisted	JJ
cord-259603-bh198xgl	794	13	β	β	NN
cord-259603-bh198xgl	794	14	-	-	HYPH
cord-259603-bh198xgl	794	15	sheet	sheet	NN
cord-259603-bh198xgl	794	16	that	that	WDT
cord-259603-bh198xgl	794	17	is	be	VBZ
cord-259603-bh198xgl	794	18	formed	form	VBN
cord-259603-bh198xgl	794	19	by	by	IN
cord-259603-bh198xgl	794	20	five	five	CD
cord-259603-bh198xgl	794	21	β	β	NN
cord-259603-bh198xgl	794	22	-	-	HYPH
cord-259603-bh198xgl	794	23	strands	strand	NNS
cord-259603-bh198xgl	794	24	and	and	CC
cord-259603-bh198xgl	794	25	flanked	flank	VBN
cord-259603-bh198xgl	794	26	by	by	IN
cord-259603-bh198xgl	794	27	α	α	NN
cord-259603-bh198xgl	794	28	-	-	HYPH
cord-259603-bh198xgl	794	29	helices	helix	NNS
cord-259603-bh198xgl	794	30	on	on	IN
cord-259603-bh198xgl	794	31	either	either	DT
cord-259603-bh198xgl	794	32	side	side	NN
cord-259603-bh198xgl	794	33	.	.	.
cord-259603-bh198xgl	795	1	It	-PRON-	PRP
cord-259603-bh198xgl	795	2	resembles	resemble	VBZ
cord-259603-bh198xgl	795	3	that	that	DT
cord-259603-bh198xgl	795	4	of	of	IN
cord-259603-bh198xgl	795	5	other	other	JJ
cord-259603-bh198xgl	795	6	DEDD	DEDD	NNP
cord-259603-bh198xgl	795	7	superfamily	superfamily	NN
cord-259603-bh198xgl	795	8	exonucleases	exonuclease	NNS
cord-259603-bh198xgl	795	9	,	,	,
cord-259603-bh198xgl	795	10	such	such	JJ
cord-259603-bh198xgl	795	11	as	as	IN
cord-259603-bh198xgl	795	12	the	the	DT
cord-259603-bh198xgl	795	13	ε	ε	NNP
cord-259603-bh198xgl	795	14	subunit	subunit	NN
cord-259603-bh198xgl	795	15	of	of	IN
cord-259603-bh198xgl	795	16	E.	E.	NNP
cord-259603-bh198xgl	795	17	coli	coli	VBZ
cord-259603-bh198xgl	795	18	DNA	dna	NN
cord-259603-bh198xgl	795	19	polymerase	polymerase	NN
cord-259603-bh198xgl	795	20	III	iii	CD
cord-259603-bh198xgl	795	21	,	,	,
cord-259603-bh198xgl	795	22	but	but	CC
cord-259603-bh198xgl	795	23	also	also	RB
cord-259603-bh198xgl	795	24	has	have	VBZ
cord-259603-bh198xgl	795	25	unique	unique	JJ
cord-259603-bh198xgl	795	26	features	feature	NNS
cord-259603-bh198xgl	795	27	.	.	.
cord-259603-bh198xgl	796	1	These	these	DT
cord-259603-bh198xgl	796	2	include	include	VBP
cord-259603-bh198xgl	796	3	two	two	CD
cord-259603-bh198xgl	796	4	segments	segment	NNS
cord-259603-bh198xgl	796	5	(	(	-LRB-
cord-259603-bh198xgl	796	6	residues	residue	NNS
cord-259603-bh198xgl	796	7	1	1	CD
cord-259603-bh198xgl	796	8	-	-	SYM
cord-259603-bh198xgl	796	9	76	76	CD
cord-259603-bh198xgl	796	10	and	and	CC
cord-259603-bh198xgl	796	11	119	119	CD
cord-259603-bh198xgl	796	12	-	-	SYM
cord-259603-bh198xgl	796	13	145	145	CD
cord-259603-bh198xgl	796	14	)	)	-RRB-
cord-259603-bh198xgl	796	15	that	that	WDT
cord-259603-bh198xgl	796	16	are	be	VBP
cord-259603-bh198xgl	796	17	involved	involve	VBN
cord-259603-bh198xgl	796	18	in	in	IN
cord-259603-bh198xgl	796	19	the	the	DT
cord-259603-bh198xgl	796	20	interaction	interaction	NN
cord-259603-bh198xgl	796	21	with	with	IN
cord-259603-bh198xgl	796	22	nsp10	nsp10	NNPS
cord-259603-bh198xgl	796	23	and	and	CC
cord-259603-bh198xgl	796	24	two	two	CD
cord-259603-bh198xgl	796	25	zinc	zinc	NN
cord-259603-bh198xgl	796	26	fingers	finger	NNS
cord-259603-bh198xgl	796	27	in	in	IN
cord-259603-bh198xgl	796	28	the	the	DT
cord-259603-bh198xgl	796	29	ExoN	ExoN	NNP
cord-259603-bh198xgl	796	30	domain	domain	NN
cord-259603-bh198xgl	796	31	(	(	-LRB-
cord-259603-bh198xgl	796	32	see	see	VB
cord-259603-bh198xgl	796	33	Fig	Fig	NNP
cord-259603-bh198xgl	796	34	.	.	NNP
cord-259603-bh198xgl	796	35	5	5	CD
cord-259603-bh198xgl	796	36	)	)	-RRB-
cord-259603-bh198xgl	796	37	.	.	.
cord-259603-bh198xgl	797	1	The	the	DT
cord-259603-bh198xgl	797	2	second	second	JJ
cord-259603-bh198xgl	797	3	zinc	zinc	NN
cord-259603-bh198xgl	797	4	finger	finger	NN
cord-259603-bh198xgl	797	5	was	be	VBD
cord-259603-bh198xgl	797	6	found	find	VBN
cord-259603-bh198xgl	797	7	in	in	IN
cord-259603-bh198xgl	797	8	close	close	JJ
cord-259603-bh198xgl	797	9	proximity	proximity	NN
cord-259603-bh198xgl	797	10	to	to	IN
cord-259603-bh198xgl	797	11	the	the	DT
cord-259603-bh198xgl	797	12	catalytic	catalytic	JJ
cord-259603-bh198xgl	797	13	site	site	NN
cord-259603-bh198xgl	797	14	.	.	.
cord-259603-bh198xgl	798	1	Both	both	DT
cord-259603-bh198xgl	798	2	its	-PRON-	PRP$
cord-259603-bh198xgl	798	3	position	position	NN
cord-259603-bh198xgl	798	4	in	in	IN
cord-259603-bh198xgl	798	5	the	the	DT
cord-259603-bh198xgl	798	6	structure	structure	NN
cord-259603-bh198xgl	798	7	and	and	CC
cord-259603-bh198xgl	798	8	mutagenesis	mutagenesis	NN
cord-259603-bh198xgl	798	9	data	datum	NNS
cord-259603-bh198xgl	798	10	support	support	VBP
cord-259603-bh198xgl	798	11	a	a	DT
cord-259603-bh198xgl	798	12	role	role	NN
cord-259603-bh198xgl	798	13	for	for	IN
cord-259603-bh198xgl	798	14	this	this	DT
cord-259603-bh198xgl	798	15	zinc	zinc	NN
cord-259603-bh198xgl	798	16	finger	finger	NN
cord-259603-bh198xgl	798	17	in	in	IN
cord-259603-bh198xgl	798	18	catalysis	catalysis	NN
cord-259603-bh198xgl	798	19	(	(	-LRB-
cord-259603-bh198xgl	798	20	Ma	Ma	NNP
cord-259603-bh198xgl	798	21	et	et	NNP
cord-259603-bh198xgl	798	22	al	al	NNP
cord-259603-bh198xgl	798	23	.	.	NNP
cord-259603-bh198xgl	798	24	,	,	,
cord-259603-bh198xgl	798	25	2015	2015	CD
cord-259603-bh198xgl	798	26	)	)	-RRB-
cord-259603-bh198xgl	798	27	.	.	.
cord-259603-bh198xgl	799	1	The	the	DT
cord-259603-bh198xgl	799	2	other	other	JJ
cord-259603-bh198xgl	799	3	zinc	zinc	NN
cord-259603-bh198xgl	799	4	finger	finger	NN
cord-259603-bh198xgl	799	5	appears	appear	VBZ
cord-259603-bh198xgl	799	6	to	to	TO
cord-259603-bh198xgl	799	7	be	be	VB
cord-259603-bh198xgl	799	8	required	require	VBN
cord-259603-bh198xgl	799	9	to	to	TO
cord-259603-bh198xgl	799	10	maintain	maintain	VB
cord-259603-bh198xgl	799	11	the	the	DT
cord-259603-bh198xgl	799	12	structural	structural	JJ
cord-259603-bh198xgl	799	13	integrity	integrity	NN
cord-259603-bh198xgl	799	14	of	of	IN
cord-259603-bh198xgl	799	15	nsp14	nsp14	NNP
cord-259603-bh198xgl	799	16	.	.	.
cord-259603-bh198xgl	800	1	Consistent	consistent	JJ
cord-259603-bh198xgl	800	2	with	with	IN
cord-259603-bh198xgl	800	3	this	this	DT
cord-259603-bh198xgl	800	4	,	,	,
cord-259603-bh198xgl	800	5	nsp14	nsp14	NN
cord-259603-bh198xgl	800	6	variants	variant	NNS
cord-259603-bh198xgl	800	7	containing	contain	VBG
cord-259603-bh198xgl	800	8	substitutions	substitution	NNS
cord-259603-bh198xgl	800	9	in	in	IN
cord-259603-bh198xgl	800	10	zinc	zinc	NN
cord-259603-bh198xgl	800	11	finger	finger	NN
cord-259603-bh198xgl	800	12	1	1	CD
cord-259603-bh198xgl	800	13	proved	prove	VBD
cord-259603-bh198xgl	800	14	to	to	TO
cord-259603-bh198xgl	800	15	be	be	VB
cord-259603-bh198xgl	800	16	insoluble	insoluble	JJ
cord-259603-bh198xgl	800	17	when	when	WRB
cord-259603-bh198xgl	800	18	expressed	express	VBN
cord-259603-bh198xgl	800	19	in	in	IN
cord-259603-bh198xgl	800	20	E.	E.	NNP
cord-259603-bh198xgl	800	21	coli	coli	NNS
cord-259603-bh198xgl	800	22	.	.	.
cord-259603-bh198xgl	801	1	Five	five	CD
cord-259603-bh198xgl	801	2	residues	residue	NNS
cord-259603-bh198xgl	801	3	predicted	predict	VBN
cord-259603-bh198xgl	801	4	to	to	TO
cord-259603-bh198xgl	801	5	coordinate	coordinate	VB
cord-259603-bh198xgl	801	6	two	two	CD
cord-259603-bh198xgl	801	7	Mg	Mg	NNP
cord-259603-bh198xgl	801	8	2	2	CD
cord-259603-bh198xgl	801	9	+	+	SYM
cord-259603-bh198xgl	801	10	ions	ion	NNS
cord-259603-bh198xgl	801	11	,	,	,
cord-259603-bh198xgl	801	12	,	,	,
cord-259603-bh198xgl	801	13	were	be	VBD
cord-259603-bh198xgl	801	14	found	find	VBN
cord-259603-bh198xgl	801	15	in	in	IN
cord-259603-bh198xgl	801	16	the	the	DT
cord-259603-bh198xgl	801	17	catalytic	catalytic	JJ
cord-259603-bh198xgl	801	18	site	site	NN
cord-259603-bh198xgl	801	19	,	,	,
cord-259603-bh198xgl	801	20	with	with	IN
cord-259603-bh198xgl	801	21	one	one	CD
cord-259603-bh198xgl	801	22	Mg	Mg	NNP
cord-259603-bh198xgl	801	23	2	2	CD
cord-259603-bh198xgl	801	24	+	+	CC
cord-259603-bh198xgl	801	25	ion	ion	NN
cord-259603-bh198xgl	801	26	being	being	NN
cord-259603-bh198xgl	801	27	coordinated	coordinate	VBN
cord-259603-bh198xgl	801	28	by	by	IN
cord-259603-bh198xgl	801	29	Asp-90	Asp-90	NNP
cord-259603-bh198xgl	801	30	(	(	-LRB-
cord-259603-bh198xgl	801	31	ExoN	ExoN	NNP
cord-259603-bh198xgl	801	32	motif	motif	NN
cord-259603-bh198xgl	801	33	I	-PRON-	PRP
cord-259603-bh198xgl	801	34	)	)	-RRB-
cord-259603-bh198xgl	801	35	and	and	CC
cord-259603-bh198xgl	801	36	Glu-191	Glu-191	NNP
cord-259603-bh198xgl	801	37	(	(	-LRB-
cord-259603-bh198xgl	801	38	motif	motif	NN
cord-259603-bh198xgl	801	39	II	ii	CD
cord-259603-bh198xgl	801	40	)	)	-RRB-
cord-259603-bh198xgl	802	1	(	(	-LRB-
cord-259603-bh198xgl	802	2	Fig	Fig	NNP
cord-259603-bh198xgl	802	3	.	.	NNP
cord-259603-bh198xgl	802	4	5	5	CD
cord-259603-bh198xgl	802	5	)	)	-RRB-
cord-259603-bh198xgl	802	6	.	.	.
cord-259603-bh198xgl	803	1	The	the	DT
cord-259603-bh198xgl	803	2	second	second	JJ
cord-259603-bh198xgl	803	3	Mg	Mg	NNP
cord-259603-bh198xgl	803	4	2	2	CD
cord-259603-bh198xgl	803	5	+	+	CC
cord-259603-bh198xgl	803	6	ion	ion	NN
cord-259603-bh198xgl	803	7	expected	expect	VBN
cord-259603-bh198xgl	803	8	to	to	TO
cord-259603-bh198xgl	803	9	be	be	VB
cord-259603-bh198xgl	803	10	involved	involve	VBN
cord-259603-bh198xgl	803	11	in	in	IN
cord-259603-bh198xgl	803	12	the	the	DT
cord-259603-bh198xgl	803	13	two	two	CD
cord-259603-bh198xgl	803	14	-	-	HYPH
cord-259603-bh198xgl	803	15	metalion	metalion	NN
cord-259603-bh198xgl	803	16	-	-	HYPH
cord-259603-bh198xgl	803	17	assisted	assist	VBN
cord-259603-bh198xgl	803	18	catalytic	catalytic	JJ
cord-259603-bh198xgl	803	19	mechanism	mechanism	NN
cord-259603-bh198xgl	803	20	of	of	IN
cord-259603-bh198xgl	803	21	ExoN	ExoN	NNP
cord-259603-bh198xgl	803	22	(	(	-LRB-
cord-259603-bh198xgl	803	23	Beese	Beese	NNP
cord-259603-bh198xgl	803	24	and	and	CC
cord-259603-bh198xgl	803	25	Steitz	Steitz	NNP
cord-259603-bh198xgl	803	26	,	,	,
cord-259603-bh198xgl	803	27	1991	1991	CD
cord-259603-bh198xgl	803	28	;	;	:
cord-259603-bh198xgl	803	29	Chen	Chen	NNP
cord-259603-bh198xgl	803	30	et	et	NNP
cord-259603-bh198xgl	803	31	al	al	NNP
cord-259603-bh198xgl	803	32	.	.	NNP
cord-259603-bh198xgl	803	33	,	,	,
cord-259603-bh198xgl	803	34	2007	2007	CD
cord-259603-bh198xgl	803	35	;	;	:
cord-259603-bh198xgl	803	36	Ulferts	Ulferts	NNP
cord-259603-bh198xgl	803	37	and	and	CC
cord-259603-bh198xgl	803	38	Ziebuhr	Ziebuhr	NNP
cord-259603-bh198xgl	803	39	,	,	,
cord-259603-bh198xgl	803	40	2011	2011	CD
cord-259603-bh198xgl	803	41	)	)	-RRB-
cord-259603-bh198xgl	803	42	was	be	VBD
cord-259603-bh198xgl	803	43	not	not	RB
cord-259603-bh198xgl	803	44	identified	identify	VBN
cord-259603-bh198xgl	803	45	,	,	,
cord-259603-bh198xgl	803	46	presumably	presumably	RB
cord-259603-bh198xgl	803	47	due	due	IN
cord-259603-bh198xgl	803	48	to	to	IN
cord-259603-bh198xgl	803	49	the	the	DT
cord-259603-bh198xgl	803	50	lack	lack	NN
cord-259603-bh198xgl	803	51	of	of	IN
cord-259603-bh198xgl	803	52	an	an	DT
cord-259603-bh198xgl	803	53	RNA	RNA	NNP
cord-259603-bh198xgl	803	54	substrate	substrate	NN
cord-259603-bh198xgl	803	55	and/or	and/or	CC
cord-259603-bh198xgl	803	56	product	product	NN
cord-259603-bh198xgl	803	57	in	in	IN
cord-259603-bh198xgl	803	58	this	this	DT
cord-259603-bh198xgl	803	59	structure	structure	NN
cord-259603-bh198xgl	803	60	.	.	.
cord-259603-bh198xgl	804	1	With	with	IN
cord-259603-bh198xgl	804	2	one	one	CD
cord-259603-bh198xgl	804	3	exception	exception	NN
cord-259603-bh198xgl	804	4	,	,	,
cord-259603-bh198xgl	804	5	metal	metal	NN
cord-259603-bh198xgl	804	6	ion	ion	NN
cord-259603-bh198xgl	804	7	-	-	HYPH
cord-259603-bh198xgl	804	8	coordinating	coordinate	VBG
cord-259603-bh198xgl	804	9	residues	residue	NNS
cord-259603-bh198xgl	804	10	identified	identify	VBN
cord-259603-bh198xgl	804	11	in	in	IN
cord-259603-bh198xgl	804	12	the	the	DT
cord-259603-bh198xgl	804	13	active	active	JJ
cord-259603-bh198xgl	804	14	site	site	NN
cord-259603-bh198xgl	804	15	corresponded	correspond	VBD
cord-259603-bh198xgl	804	16	well	well	RB
cord-259603-bh198xgl	804	17	to	to	IN
cord-259603-bh198xgl	804	18	those	those	DT
cord-259603-bh198xgl	804	19	identified	identify	VBN
cord-259603-bh198xgl	804	20	in	in	IN
cord-259603-bh198xgl	804	21	related	related	JJ
cord-259603-bh198xgl	804	22	cellular	cellular	JJ
cord-259603-bh198xgl	804	23	proofreading	proofreading	NN
cord-259603-bh198xgl	804	24	exonucleases	exonuclease	NNS
cord-259603-bh198xgl	805	1	(	(	-LRB-
cord-259603-bh198xgl	805	2	Beese	Beese	NNP
cord-259603-bh198xgl	805	3	et	et	NNP
cord-259603-bh198xgl	805	4	al	al	NNP
cord-259603-bh198xgl	805	5	.	.	.
cord-259603-bh198xgl	806	1	,	,	,
cord-259603-bh198xgl	806	2	1993	1993	CD
cord-259603-bh198xgl	806	3	;	;	:
cord-259603-bh198xgl	806	4	Hamdan	Hamdan	NNP
cord-259603-bh198xgl	806	5	et	et	NNP
cord-259603-bh198xgl	806	6	al	al	NNP
cord-259603-bh198xgl	806	7	.	.	NNP
cord-259603-bh198xgl	806	8	,	,	,
cord-259603-bh198xgl	806	9	2002	2002	CD
cord-259603-bh198xgl	806	10	)	)	-RRB-
cord-259603-bh198xgl	806	11	and	and	CC
cord-259603-bh198xgl	806	12	previous	previous	JJ
cord-259603-bh198xgl	806	13	predictions	prediction	NNS
cord-259603-bh198xgl	806	14	for	for	IN
cord-259603-bh198xgl	806	15	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	806	16	homologs	homolog	NNS
cord-259603-bh198xgl	807	1	(	(	-LRB-
cord-259603-bh198xgl	807	2	Snijder	Snijder	NNP
cord-259603-bh198xgl	807	3	et	et	NNP
cord-259603-bh198xgl	807	4	al	al	NNP
cord-259603-bh198xgl	807	5	.	.	NNP
cord-259603-bh198xgl	807	6	,	,	,
cord-259603-bh198xgl	807	7	2003	2003	CD
cord-259603-bh198xgl	807	8	)	)	-RRB-
cord-259603-bh198xgl	807	9	.	.	.
cord-259603-bh198xgl	808	1	The	the	DT
cord-259603-bh198xgl	808	2	structure	structure	NN
cord-259603-bh198xgl	808	3	clearly	clearly	RB
cord-259603-bh198xgl	808	4	revealed	reveal	VBD
cord-259603-bh198xgl	808	5	to	to	TO
cord-259603-bh198xgl	808	6	be	be	VB
cord-259603-bh198xgl	808	7	involved	involve	VBN
cord-259603-bh198xgl	808	8	in	in	IN
cord-259603-bh198xgl	808	9	catalysis	catalysis	NN
cord-259603-bh198xgl	808	10	,	,	,
cord-259603-bh198xgl	808	11	thus	thus	RB
cord-259603-bh198xgl	808	12	revising	revise	VBG
cord-259603-bh198xgl	808	13	previous	previous	JJ
cord-259603-bh198xgl	808	14	predictions	prediction	NNS
cord-259603-bh198xgl	808	15	on	on	IN
cord-259603-bh198xgl	808	16	the	the	DT
cord-259603-bh198xgl	808	17	identity	identity	NN
cord-259603-bh198xgl	808	18	of	of	IN
cord-259603-bh198xgl	808	19	ExoN	ExoN	NNP
cord-259603-bh198xgl	808	20	motif	motif	NN
cord-259603-bh198xgl	808	21	II	II	NNP
cord-259603-bh198xgl	808	22	in	in	IN
cord-259603-bh198xgl	808	23	the	the	DT
cord-259603-bh198xgl	808	24	CoV	cov	NN
cord-259603-bh198xgl	808	25	nsp14	nsp14	CD
cord-259603-bh198xgl	808	26	primary	primary	JJ
cord-259603-bh198xgl	808	27	structure	structure	NN
cord-259603-bh198xgl	808	28	and	and	CC
cord-259603-bh198xgl	808	29	making	make	VBG
cord-259603-bh198xgl	808	30	nsp14	nsp14	XX
cord-259603-bh198xgl	808	31	a	a	DT
cord-259603-bh198xgl	808	32	"	"	``
cord-259603-bh198xgl	808	33	DEED	deed	NN
cord-259603-bh198xgl	808	34	outlier	outlier	NN
cord-259603-bh198xgl	808	35	"	"	''
cord-259603-bh198xgl	808	36	in	in	IN
cord-259603-bh198xgl	808	37	the	the	DT
cord-259603-bh198xgl	808	38	DEDD	DEDD	NNP
cord-259603-bh198xgl	808	39	superfamily	superfamily	NN
cord-259603-bh198xgl	808	40	of	of	IN
cord-259603-bh198xgl	808	41	exonucleases	exonuclease	NNS
cord-259603-bh198xgl	808	42	.	.	.
cord-259603-bh198xgl	809	1	The	the	DT
cord-259603-bh198xgl	809	2	combined	combined	JJ
cord-259603-bh198xgl	809	3	structural	structural	JJ
cord-259603-bh198xgl	809	4	and	and	CC
cord-259603-bh198xgl	809	5	functional	functional	JJ
cord-259603-bh198xgl	809	6	information	information	NN
cord-259603-bh198xgl	809	7	obtained	obtain	VBN
cord-259603-bh198xgl	809	8	for	for	IN
cord-259603-bh198xgl	809	9	nsp14	nsp14	NNP
cord-259603-bh198xgl	809	10	including	include	VBG
cord-259603-bh198xgl	809	11	its	-PRON-	PRP$
cord-259603-bh198xgl	809	12	subdomains	subdomain	NNS
cord-259603-bh198xgl	809	13	and	and	CC
cord-259603-bh198xgl	809	14	the	the	DT
cord-259603-bh198xgl	809	15	nsp10	nsp10	NNP
cord-259603-bh198xgl	809	16	cofactor	cofactor	NN
cord-259603-bh198xgl	810	1	provides	provide	VBZ
cord-259603-bh198xgl	810	2	an	an	DT
cord-259603-bh198xgl	810	3	excellent	excellent	JJ
cord-259603-bh198xgl	810	4	basis	basis	NN
cord-259603-bh198xgl	810	5	for	for	IN
cord-259603-bh198xgl	810	6	studies	study	NNS
cord-259603-bh198xgl	810	7	using	use	VBG
cord-259603-bh198xgl	810	8	even	even	RB
cord-259603-bh198xgl	810	9	larger	large	JJR
cord-259603-bh198xgl	810	10	multisubunit	multisubunit	NNP
cord-259603-bh198xgl	810	11	complexes	complex	NNS
cord-259603-bh198xgl	810	12	to	to	TO
cord-259603-bh198xgl	810	13	obtain	obtain	VB
cord-259603-bh198xgl	810	14	insight	insight	NN
cord-259603-bh198xgl	810	15	into	into	IN
cord-259603-bh198xgl	810	16	the	the	DT
cord-259603-bh198xgl	810	17	coordinated	coordinated	JJ
cord-259603-bh198xgl	810	18	action	action	NN
cord-259603-bh198xgl	810	19	of	of	IN
cord-259603-bh198xgl	810	20	key	key	JJ
cord-259603-bh198xgl	810	21	replicative	replicative	JJ
cord-259603-bh198xgl	810	22	enzymes	enzyme	NNS
cord-259603-bh198xgl	810	23	involved	involve	VBN
cord-259603-bh198xgl	810	24	in	in	IN
cord-259603-bh198xgl	810	25	RNA	RNA	NNP
cord-259603-bh198xgl	810	26	synthesis	synthesis	NN
cord-259603-bh198xgl	810	27	,	,	,
cord-259603-bh198xgl	810	28	quality	quality	NN
cord-259603-bh198xgl	810	29	control	control	NN
cord-259603-bh198xgl	810	30	,	,	,
cord-259603-bh198xgl	810	31	capping	capping	NN
cord-259603-bh198xgl	810	32	,	,	,
cord-259603-bh198xgl	810	33	methylation	methylation	NN
cord-259603-bh198xgl	810	34	,	,	,
cord-259603-bh198xgl	810	35	and	and	CC
cord-259603-bh198xgl	810	36	other	other	JJ
cord-259603-bh198xgl	810	37	functions	function	NNS
cord-259603-bh198xgl	810	38	(	(	-LRB-
cord-259603-bh198xgl	810	39	Subissi	Subissi	NNP
cord-259603-bh198xgl	810	40	et	et	NNP
cord-259603-bh198xgl	810	41	al	al	NNP
cord-259603-bh198xgl	810	42	.	.	NNP
cord-259603-bh198xgl	810	43	,	,	,
cord-259603-bh198xgl	810	44	2014a	2014a	CD
cord-259603-bh198xgl	810	45	)	)	-RRB-
cord-259603-bh198xgl	810	46	.	.	.
cord-259603-bh198xgl	811	1	The	the	DT
cord-259603-bh198xgl	811	2	nsp15-associated	nsp15-associated	JJ
cord-259603-bh198xgl	811	3	endoU	endoU	NNP
cord-259603-bh198xgl	811	4	domain	domain	NN
cord-259603-bh198xgl	811	5	is	be	VBZ
cord-259603-bh198xgl	811	6	one	one	CD
cord-259603-bh198xgl	811	7	of	of	IN
cord-259603-bh198xgl	811	8	the	the	DT
cord-259603-bh198xgl	811	9	most	most	RBS
cord-259603-bh198xgl	811	10	conserved	conserved	JJ
cord-259603-bh198xgl	811	11	proteins	protein	NNS
cord-259603-bh198xgl	811	12	among	among	IN
cord-259603-bh198xgl	811	13	CoVs	CoVs	NNP
cord-259603-bh198xgl	811	14	and	and	CC
cord-259603-bh198xgl	811	15	related	relate	VBN
cord-259603-bh198xgl	811	16	viruses	virus	NNS
cord-259603-bh198xgl	812	1	(	(	-LRB-
cord-259603-bh198xgl	812	2	Fig	Fig	NNP
cord-259603-bh198xgl	812	3	.	.	.
cord-259603-bh198xgl	812	4	8)	8)	NNP
cord-259603-bh198xgl	812	5	,	,	,
cord-259603-bh198xgl	812	6	suggesting	suggest	VBG
cord-259603-bh198xgl	812	7	important	important	JJ
cord-259603-bh198xgl	812	8	functions	function	NNS
cord-259603-bh198xgl	812	9	in	in	IN
cord-259603-bh198xgl	812	10	the	the	DT
cord-259603-bh198xgl	812	11	viral	viral	JJ
cord-259603-bh198xgl	812	12	replicative	replicative	JJ
cord-259603-bh198xgl	812	13	cycle	cycle	NN
cord-259603-bh198xgl	812	14	.	.	.
cord-259603-bh198xgl	813	1	Already	already	RB
cord-259603-bh198xgl	813	2	in	in	IN
cord-259603-bh198xgl	813	3	the	the	DT
cord-259603-bh198xgl	813	4	first	first	JJ
cord-259603-bh198xgl	813	5	sequence	sequence	NN
cord-259603-bh198xgl	813	6	analyses	analysis	NNS
cord-259603-bh198xgl	813	7	of	of	IN
cord-259603-bh198xgl	813	8	torovirus	torovirus	NNP
cord-259603-bh198xgl	813	9	and	and	CC
cord-259603-bh198xgl	813	10	arterivirus	arterivirus	NNP
cord-259603-bh198xgl	813	11	replicase	replicase	NNP
cord-259603-bh198xgl	813	12	genes	gene	NNS
cord-259603-bh198xgl	813	13	published	publish	VBD
cord-259603-bh198xgl	813	14	more	more	JJR
cord-259603-bh198xgl	813	15	than	than	IN
cord-259603-bh198xgl	813	16	25	25	CD
cord-259603-bh198xgl	813	17	years	year	NNS
cord-259603-bh198xgl	813	18	ago	ago	RB
cord-259603-bh198xgl	814	1	(	(	-LRB-
cord-259603-bh198xgl	814	2	den	den	NNP
cord-259603-bh198xgl	814	3	Boon	Boon	NNP
cord-259603-bh198xgl	814	4	et	et	NNP
cord-259603-bh198xgl	814	5	al	al	NNP
cord-259603-bh198xgl	814	6	.	.	NNP
cord-259603-bh198xgl	814	7	,	,	,
cord-259603-bh198xgl	814	8	1991	1991	CD
cord-259603-bh198xgl	814	9	;	;	:
cord-259603-bh198xgl	814	10	Snijder	Snijder	NNP
cord-259603-bh198xgl	814	11	et	et	NNP
cord-259603-bh198xgl	814	12	al	al	NNP
cord-259603-bh198xgl	814	13	.	.	NNP
cord-259603-bh198xgl	814	14	,	,	,
cord-259603-bh198xgl	814	15	1990	1990	CD
cord-259603-bh198xgl	814	16	)	)	-RRB-
cord-259603-bh198xgl	814	17	,	,	,
cord-259603-bh198xgl	814	18	the	the	DT
cord-259603-bh198xgl	814	19	identification	identification	NN
cord-259603-bh198xgl	814	20	of	of	IN
cord-259603-bh198xgl	814	21	a	a	DT
cord-259603-bh198xgl	814	22	conserved	conserved	JJ
cord-259603-bh198xgl	814	23	sequence	sequence	NN
cord-259603-bh198xgl	814	24	in	in	IN
cord-259603-bh198xgl	814	25	the	the	DT
cord-259603-bh198xgl	814	26	3	3	CD
cord-259603-bh198xgl	814	27	0	0	CD
cord-259603-bh198xgl	814	28	-terminal	-terminal	JJ
cord-259603-bh198xgl	814	29	ORF1b	orf1b	JJ
cord-259603-bh198xgl	814	30	region	region	NN
cord-259603-bh198xgl	814	31	,	,	,
cord-259603-bh198xgl	814	32	including	include	VBG
cord-259603-bh198xgl	814	33	the	the	DT
cord-259603-bh198xgl	814	34	(	(	-LRB-
cord-259603-bh198xgl	814	35	at	at	IN
cord-259603-bh198xgl	814	36	the	the	DT
cord-259603-bh198xgl	814	37	time	time	NN
cord-259603-bh198xgl	814	38	unknown	unknown	JJ
cord-259603-bh198xgl	814	39	)	)	-RRB-
cord-259603-bh198xgl	814	40	endoU	endou	JJ
cord-259603-bh198xgl	814	41	domain	domain	NN
cord-259603-bh198xgl	814	42	,	,	,
cord-259603-bh198xgl	814	43	was	be	VBD
cord-259603-bh198xgl	814	44	key	key	JJ
cord-259603-bh198xgl	814	45	to	to	IN
cord-259603-bh198xgl	814	46	establishing	establish	VBG
cord-259603-bh198xgl	814	47	phylogenetic	phylogenetic	JJ
cord-259603-bh198xgl	814	48	relationships	relationship	NNS
cord-259603-bh198xgl	814	49	between	between	IN
cord-259603-bh198xgl	814	50	corona	corona	NN
cord-259603-bh198xgl	814	51	-	-	HYPH
cord-259603-bh198xgl	814	52	and	and	CC
cord-259603-bh198xgl	814	53	toroviruses	toroviruse	NNS
cord-259603-bh198xgl	814	54	and	and	CC
cord-259603-bh198xgl	814	55	,	,	,
cord-259603-bh198xgl	814	56	subsequently	subsequently	RB
cord-259603-bh198xgl	814	57	,	,	,
cord-259603-bh198xgl	814	58	also	also	RB
cord-259603-bh198xgl	814	59	arteriviruses	arteriviruses	NNP
cord-259603-bh198xgl	814	60	(	(	-LRB-
cord-259603-bh198xgl	814	61	Cavanagh	Cavanagh	NNP
cord-259603-bh198xgl	814	62	and	and	CC
cord-259603-bh198xgl	814	63	Horzinek	Horzinek	NNP
cord-259603-bh198xgl	814	64	,	,	,
cord-259603-bh198xgl	814	65	1993	1993	CD
cord-259603-bh198xgl	814	66	;	;	:
cord-259603-bh198xgl	815	1	Snijder	Snijder	NNP
cord-259603-bh198xgl	815	2	et	et	NNP
cord-259603-bh198xgl	815	3	al	al	NNP
cord-259603-bh198xgl	815	4	.	.	NNP
cord-259603-bh198xgl	815	5	,	,	,
cord-259603-bh198xgl	815	6	1993	1993	CD
cord-259603-bh198xgl	815	7	)	)	-RRB-
cord-259603-bh198xgl	815	8	.	.	.
cord-259603-bh198xgl	816	1	Outside	outside	IN
cord-259603-bh198xgl	816	2	the	the	DT
cord-259603-bh198xgl	816	3	Nidovirales	Nidovirales	NNPS
cord-259603-bh198xgl	816	4	,	,	,
cord-259603-bh198xgl	816	5	no	no	DT
cord-259603-bh198xgl	816	6	viral	viral	JJ
cord-259603-bh198xgl	816	7	homologs	homolog	NNS
cord-259603-bh198xgl	816	8	of	of	IN
cord-259603-bh198xgl	816	9	endoU	endoU	NNP
cord-259603-bh198xgl	816	10	have	have	VBP
cord-259603-bh198xgl	816	11	been	be	VBN
cord-259603-bh198xgl	816	12	identified	identify	VBN
cord-259603-bh198xgl	816	13	to	to	IN
cord-259603-bh198xgl	816	14	date	date	NN
cord-259603-bh198xgl	816	15	.	.	.
cord-259603-bh198xgl	817	1	Together	together	RB
cord-259603-bh198xgl	817	2	with	with	IN
cord-259603-bh198xgl	817	3	the	the	DT
cord-259603-bh198xgl	817	4	helicase	helicase	NN
cord-259603-bh198xgl	817	5	-	-	HYPH
cord-259603-bh198xgl	817	6	associated	associate	VBN
cord-259603-bh198xgl	817	7	ZBD	ZBD	NNP
cord-259603-bh198xgl	817	8	(	(	-LRB-
cord-259603-bh198xgl	817	9	see	see	VB
cord-259603-bh198xgl	817	10	earlier	early	RBR
cord-259603-bh198xgl	817	11	)	)	-RRB-
cord-259603-bh198xgl	817	12	,	,	,
cord-259603-bh198xgl	817	13	the	the	DT
cord-259603-bh198xgl	817	14	nidoviral	nidoviral	JJ
cord-259603-bh198xgl	817	15	endoU	endoU	NNP
cord-259603-bh198xgl	817	16	has	have	VBZ
cord-259603-bh198xgl	817	17	therefore	therefore	RB
cord-259603-bh198xgl	817	18	been	be	VBN
cord-259603-bh198xgl	817	19	proposed	propose	VBN
cord-259603-bh198xgl	817	20	to	to	TO
cord-259603-bh198xgl	817	21	be	be	VB
cord-259603-bh198xgl	817	22	a	a	DT
cord-259603-bh198xgl	817	23	unique	unique	JJ
cord-259603-bh198xgl	817	24	and	and	CC
cord-259603-bh198xgl	817	25	universally	universally	RB
cord-259603-bh198xgl	817	26	conserved	conserved	JJ
cord-259603-bh198xgl	817	27	genetic	genetic	JJ
cord-259603-bh198xgl	817	28	marker	marker	NN
cord-259603-bh198xgl	817	29	common	common	JJ
cord-259603-bh198xgl	817	30	to	to	IN
cord-259603-bh198xgl	817	31	all	all	DT
cord-259603-bh198xgl	817	32	nidoviruses	nidoviruse	NNS
cord-259603-bh198xgl	818	1	(	(	-LRB-
cord-259603-bh198xgl	818	2	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	818	3	et	et	NNP
cord-259603-bh198xgl	818	4	al	al	NNP
cord-259603-bh198xgl	818	5	.	.	NNP
cord-259603-bh198xgl	818	6	,	,	,
cord-259603-bh198xgl	818	7	2004a	2004a	CD
cord-259603-bh198xgl	818	8	;	;	:
cord-259603-bh198xgl	818	9	Snijder	Snijder	NNP
cord-259603-bh198xgl	818	10	et	et	NNP
cord-259603-bh198xgl	818	11	al	al	NNP
cord-259603-bh198xgl	818	12	.	.	NNP
cord-259603-bh198xgl	818	13	,	,	,
cord-259603-bh198xgl	818	14	2003	2003	CD
cord-259603-bh198xgl	818	15	)	)	-RRB-
cord-259603-bh198xgl	818	16	.	.	.
cord-259603-bh198xgl	819	1	Only	only	RB
cord-259603-bh198xgl	819	2	recently	recently	RB
cord-259603-bh198xgl	819	3	,	,	,
cord-259603-bh198xgl	819	4	with	with	IN
cord-259603-bh198xgl	819	5	the	the	DT
cord-259603-bh198xgl	819	6	identification	identification	NN
cord-259603-bh198xgl	819	7	of	of	IN
cord-259603-bh198xgl	819	8	the	the	DT
cord-259603-bh198xgl	819	9	first	first	JJ
cord-259603-bh198xgl	819	10	nidoviruses	nidoviruse	NNS
cord-259603-bh198xgl	819	11	in	in	IN
cord-259603-bh198xgl	819	12	insects	insect	NNS
cord-259603-bh198xgl	819	13	(	(	-LRB-
cord-259603-bh198xgl	819	14	now	now	RB
cord-259603-bh198xgl	819	15	classified	classify	VBN
cord-259603-bh198xgl	819	16	in	in	IN
cord-259603-bh198xgl	819	17	the	the	DT
cord-259603-bh198xgl	819	18	family	family	NN
cord-259603-bh198xgl	819	19	Mesoniviridae	Mesoniviridae	NNP
cord-259603-bh198xgl	819	20	)	)	-RRB-
cord-259603-bh198xgl	819	21	and	and	CC
cord-259603-bh198xgl	819	22	reanalysis	reanalysis	NN
cord-259603-bh198xgl	819	23	of	of	IN
cord-259603-bh198xgl	819	24	the	the	DT
cord-259603-bh198xgl	819	25	ronivirus	ronivirus	NNP
cord-259603-bh198xgl	819	26	replicase	replicase	NNP
cord-259603-bh198xgl	819	27	gene	gene	NN
cord-259603-bh198xgl	819	28	,	,	,
cord-259603-bh198xgl	819	29	it	-PRON-	PRP
cord-259603-bh198xgl	819	30	was	be	VBD
cord-259603-bh198xgl	819	31	found	find	VBN
cord-259603-bh198xgl	819	32	that	that	IN
cord-259603-bh198xgl	819	33	endoU	endoU	NNP
cord-259603-bh198xgl	819	34	is	be	VBZ
cord-259603-bh198xgl	819	35	not	not	RB
cord-259603-bh198xgl	819	36	conserved	conserve	VBN
cord-259603-bh198xgl	819	37	in	in	IN
cord-259603-bh198xgl	819	38	those	those	DT
cord-259603-bh198xgl	819	39	nidovirus	nidovirus	NN
cord-259603-bh198xgl	819	40	branches	branch	NNS
cord-259603-bh198xgl	819	41	that	that	WDT
cord-259603-bh198xgl	819	42	replicate	replicate	VBP
cord-259603-bh198xgl	819	43	in	in	IN
cord-259603-bh198xgl	819	44	invertebrate	invertebrate	JJ
cord-259603-bh198xgl	819	45	hosts	host	NNS
cord-259603-bh198xgl	819	46	(	(	-LRB-
cord-259603-bh198xgl	819	47	Mesoniviridae	Mesoniviridae	NNP
cord-259603-bh198xgl	819	48	,	,	,
cord-259603-bh198xgl	819	49	Roniviridae	Roniviridae	NNP
cord-259603-bh198xgl	819	50	)	)	-RRB-
cord-259603-bh198xgl	820	1	(	(	-LRB-
cord-259603-bh198xgl	820	2	Lauber	Lauber	NNP
cord-259603-bh198xgl	820	3	et	et	FW
cord-259603-bh198xgl	820	4	al	al	NNP
cord-259603-bh198xgl	820	5	.	.	.
cord-259603-bh198xgl	821	1	,	,	,
cord-259603-bh198xgl	821	2	2012	2012	CD
cord-259603-bh198xgl	822	1	(	(	-LRB-
cord-259603-bh198xgl	822	2	Lauber	Lauber	NNP
cord-259603-bh198xgl	822	3	et	et	FW
cord-259603-bh198xgl	822	4	al	al	NNP
cord-259603-bh198xgl	822	5	.	.	.
cord-259603-bh198xgl	823	1	,	,	,
cord-259603-bh198xgl	823	2	,	,	,
cord-259603-bh198xgl	823	3	2013	2013	CD
cord-259603-bh198xgl	824	1	Nga	Nga	NNP
cord-259603-bh198xgl	824	2	et	et	NNP
cord-259603-bh198xgl	824	3	al	al	NNP
cord-259603-bh198xgl	824	4	.	.	NNP
cord-259603-bh198xgl	824	5	,	,	,
cord-259603-bh198xgl	824	6	2011	2011	CD
cord-259603-bh198xgl	824	7	;	;	:
cord-259603-bh198xgl	824	8	Zirkel	Zirkel	NNP
cord-259603-bh198xgl	824	9	et	et	NNP
cord-259603-bh198xgl	824	10	al	al	NNP
cord-259603-bh198xgl	824	11	.	.	.
cord-259603-bh198xgl	825	1	,	,	,
cord-259603-bh198xgl	825	2	2013	2013	CD
cord-259603-bh198xgl	825	3	)	)	-RRB-
cord-259603-bh198xgl	825	4	,	,	,
cord-259603-bh198xgl	825	5	suggesting	suggest	VBG
cord-259603-bh198xgl	825	6	specific	specific	JJ
cord-259603-bh198xgl	825	7	roles	role	NNS
cord-259603-bh198xgl	825	8	in	in	IN
cord-259603-bh198xgl	825	9	vertebrate	vertebrate	JJ
cord-259603-bh198xgl	825	10	hosts	host	NNS
cord-259603-bh198xgl	825	11	.	.	.
cord-259603-bh198xgl	826	1	To	to	IN
cord-259603-bh198xgl	826	2	date	date	NN
cord-259603-bh198xgl	826	3	,	,	,
cord-259603-bh198xgl	826	4	these	these	DT
cord-259603-bh198xgl	826	5	functions	function	NNS
cord-259603-bh198xgl	826	6	and	and	CC
cord-259603-bh198xgl	826	7	,	,	,
cord-259603-bh198xgl	826	8	more	more	RBR
cord-259603-bh198xgl	826	9	specifically	specifically	RB
cord-259603-bh198xgl	826	10	,	,	,
cord-259603-bh198xgl	826	11	the	the	DT
cord-259603-bh198xgl	826	12	biologically	biologically	RB
cord-259603-bh198xgl	826	13	relevant	relevant	JJ
cord-259603-bh198xgl	826	14	substrates	substrate	NNS
cord-259603-bh198xgl	826	15	of	of	IN
cord-259603-bh198xgl	826	16	endoU	endoU	NNP
cord-259603-bh198xgl	826	17	have	have	VBP
cord-259603-bh198xgl	826	18	not	not	RB
cord-259603-bh198xgl	826	19	been	be	VBN
cord-259603-bh198xgl	826	20	identified	identify	VBN
cord-259603-bh198xgl	826	21	.	.	.
cord-259603-bh198xgl	827	1	Characterization	characterization	NN
cord-259603-bh198xgl	827	2	of	of	IN
cord-259603-bh198xgl	827	3	MHV	MHV	NNP
cord-259603-bh198xgl	827	4	endoU	endoU	NNP
cord-259603-bh198xgl	827	5	knockout	knockout	NN
cord-259603-bh198xgl	827	6	mutants	mutant	NNS
cord-259603-bh198xgl	827	7	revealed	reveal	VBD
cord-259603-bh198xgl	827	8	only	only	RB
cord-259603-bh198xgl	827	9	minor	minor	JJ
cord-259603-bh198xgl	827	10	effects	effect	NNS
cord-259603-bh198xgl	827	11	on	on	IN
cord-259603-bh198xgl	827	12	viral	viral	JJ
cord-259603-bh198xgl	827	13	RNA	RNA	NNP
cord-259603-bh198xgl	827	14	synthesis	synthesis	NN
cord-259603-bh198xgl	827	15	in	in	IN
cord-259603-bh198xgl	827	16	infected	infected	JJ
cord-259603-bh198xgl	827	17	cells	cell	NNS
cord-259603-bh198xgl	827	18	,	,	,
cord-259603-bh198xgl	827	19	with	with	IN
cord-259603-bh198xgl	827	20	all	all	DT
cord-259603-bh198xgl	827	21	RNA	RNA	NNP
cord-259603-bh198xgl	827	22	species	specie	NNS
cord-259603-bh198xgl	827	23	being	be	VBG
cord-259603-bh198xgl	827	24	equally	equally	RB
cord-259603-bh198xgl	827	25	affected	affect	VBN
cord-259603-bh198xgl	827	26	,	,	,
cord-259603-bh198xgl	827	27	and	and	CC
cord-259603-bh198xgl	827	28	caused	cause	VBD
cord-259603-bh198xgl	827	29	a	a	DT
cord-259603-bh198xgl	827	30	slight	slight	JJ
cord-259603-bh198xgl	827	31	reduction	reduction	NN
cord-259603-bh198xgl	827	32	in	in	IN
cord-259603-bh198xgl	827	33	virus	virus	NN
cord-259603-bh198xgl	827	34	titers	titer	NNS
cord-259603-bh198xgl	827	35	,	,	,
cord-259603-bh198xgl	827	36	which	which	WDT
cord-259603-bh198xgl	827	37	was	be	VBD
cord-259603-bh198xgl	827	38	most	most	RBS
cord-259603-bh198xgl	827	39	evident	evident	JJ
cord-259603-bh198xgl	827	40	at	at	IN
cord-259603-bh198xgl	827	41	later	later	JJ
cord-259603-bh198xgl	827	42	time	time	NN
cord-259603-bh198xgl	827	43	points	point	NNS
cord-259603-bh198xgl	827	44	post	post	NN
cord-259603-bh198xgl	827	45	infection	infection	NN
cord-259603-bh198xgl	828	1	(	(	-LRB-
cord-259603-bh198xgl	828	2	Kang	Kang	NNP
cord-259603-bh198xgl	828	3	et	et	NNP
cord-259603-bh198xgl	828	4	al	al	NNP
cord-259603-bh198xgl	828	5	.	.	NNP
cord-259603-bh198xgl	828	6	,	,	,
cord-259603-bh198xgl	828	7	2007	2007	CD
cord-259603-bh198xgl	828	8	)	)	-RRB-
cord-259603-bh198xgl	828	9	.	.	.
cord-259603-bh198xgl	829	1	For	for	IN
cord-259603-bh198xgl	829	2	the	the	DT
cord-259603-bh198xgl	829	3	arterivirus	arterivirus	NNP
cord-259603-bh198xgl	829	4	EAV	EAV	NNP
cord-259603-bh198xgl	829	5	,	,	,
cord-259603-bh198xgl	829	6	substitutions	substitution	NNS
cord-259603-bh198xgl	829	7	of	of	IN
cord-259603-bh198xgl	829	8	several	several	JJ
cord-259603-bh198xgl	829	9	conserved	conserved	JJ
cord-259603-bh198xgl	829	10	residues	residue	NNS
cord-259603-bh198xgl	829	11	in	in	IN
cord-259603-bh198xgl	829	12	the	the	DT
cord-259603-bh198xgl	829	13	endoU	endoU	NNP
cord-259603-bh198xgl	829	14	domain	domain	NN
cord-259603-bh198xgl	829	15	were	be	VBD
cord-259603-bh198xgl	829	16	found	find	VBN
cord-259603-bh198xgl	829	17	to	to	TO
cord-259603-bh198xgl	829	18	cause	cause	VB
cord-259603-bh198xgl	829	19	more	more	RBR
cord-259603-bh198xgl	829	20	profound	profound	JJ
cord-259603-bh198xgl	829	21	effects	effect	NNS
cord-259603-bh198xgl	829	22	,	,	,
cord-259603-bh198xgl	829	23	both	both	CC
cord-259603-bh198xgl	829	24	in	in	IN
cord-259603-bh198xgl	829	25	virus	virus	NN
cord-259603-bh198xgl	829	26	reproduction	reproduction	NN
cord-259603-bh198xgl	829	27	and	and	CC
cord-259603-bh198xgl	829	28	viral	viral	JJ
cord-259603-bh198xgl	829	29	RNA	RNA	NNP
cord-259603-bh198xgl	829	30	accumulation	accumulation	NN
cord-259603-bh198xgl	829	31	,	,	,
cord-259603-bh198xgl	829	32	with	with	IN
cord-259603-bh198xgl	829	33	sg	sg	NNP
cord-259603-bh198xgl	829	34	RNA	RNA	NNP
cord-259603-bh198xgl	829	35	being	be	VBG
cord-259603-bh198xgl	829	36	more	more	RBR
cord-259603-bh198xgl	829	37	affected	affect	VBN
cord-259603-bh198xgl	829	38	than	than	IN
cord-259603-bh198xgl	829	39	genome	genome	NN
cord-259603-bh198xgl	829	40	replication	replication	NN
cord-259603-bh198xgl	829	41	in	in	IN
cord-259603-bh198xgl	829	42	several	several	JJ
cord-259603-bh198xgl	829	43	mutants	mutant	NNS
cord-259603-bh198xgl	829	44	.	.	.
cord-259603-bh198xgl	830	1	In	in	IN
cord-259603-bh198xgl	830	2	some	some	DT
cord-259603-bh198xgl	830	3	cases	case	NNS
cord-259603-bh198xgl	830	4	,	,	,
cord-259603-bh198xgl	830	5	reduction	reduction	NN
cord-259603-bh198xgl	830	6	in	in	IN
cord-259603-bh198xgl	830	7	virus	virus	NN
cord-259603-bh198xgl	830	8	titers	titer	NNS
cord-259603-bh198xgl	830	9	by	by	IN
cord-259603-bh198xgl	830	10	up	up	IN
cord-259603-bh198xgl	830	11	to	to	TO
cord-259603-bh198xgl	830	12	5	5	CD
cord-259603-bh198xgl	830	13	log	log	NN
cord-259603-bh198xgl	830	14	was	be	VBD
cord-259603-bh198xgl	830	15	observed	observe	VBN
cord-259603-bh198xgl	830	16	(	(	-LRB-
cord-259603-bh198xgl	830	17	Posthuma	Posthuma	NNP
cord-259603-bh198xgl	830	18	et	et	NNP
cord-259603-bh198xgl	830	19	al	al	NNP
cord-259603-bh198xgl	830	20	.	.	NNP
cord-259603-bh198xgl	830	21	,	,	,
cord-259603-bh198xgl	830	22	2006	2006	CD
cord-259603-bh198xgl	830	23	)	)	-RRB-
cord-259603-bh198xgl	830	24	.	.	.
cord-259603-bh198xgl	831	1	The	the	DT
cord-259603-bh198xgl	831	2	(	(	-LRB-
cord-259603-bh198xgl	831	3	limited	limited	JJ
cord-259603-bh198xgl	831	4	)	)	-RRB-
cord-259603-bh198xgl	831	5	information	information	NN
cord-259603-bh198xgl	831	6	obtained	obtain	VBN
cord-259603-bh198xgl	831	7	in	in	IN
cord-259603-bh198xgl	831	8	these	these	DT
cord-259603-bh198xgl	831	9	studies	study	NNS
cord-259603-bh198xgl	831	10	suggests	suggest	VBZ
cord-259603-bh198xgl	831	11	that	that	IN
cord-259603-bh198xgl	831	12	endoU	endou	JJ
cord-259603-bh198xgl	831	13	activity	activity	NN
cord-259603-bh198xgl	831	14	is	be	VBZ
cord-259603-bh198xgl	831	15	not	not	RB
cord-259603-bh198xgl	831	16	strictly	strictly	RB
cord-259603-bh198xgl	831	17	required	require	VBN
cord-259603-bh198xgl	831	18	for	for	IN
cord-259603-bh198xgl	831	19	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	831	20	RNA	RNA	NNP
cord-259603-bh198xgl	831	21	synthesis	synthesis	NN
cord-259603-bh198xgl	831	22	,	,	,
cord-259603-bh198xgl	831	23	at	at	IN
cord-259603-bh198xgl	831	24	least	least	JJS
cord-259603-bh198xgl	831	25	in	in	IN
cord-259603-bh198xgl	831	26	cell	cell	NN
cord-259603-bh198xgl	831	27	culture	culture	NN
cord-259603-bh198xgl	831	28	.	.	.
cord-259603-bh198xgl	832	1	However	however	RB
cord-259603-bh198xgl	832	2	,	,	,
cord-259603-bh198xgl	832	3	the	the	DT
cord-259603-bh198xgl	832	4	strong	strong	JJ
cord-259603-bh198xgl	832	5	conservation	conservation	NN
cord-259603-bh198xgl	832	6	clearly	clearly	RB
cord-259603-bh198xgl	832	7	suggests	suggest	VBZ
cord-259603-bh198xgl	832	8	an	an	DT
cord-259603-bh198xgl	832	9	important	important	JJ
cord-259603-bh198xgl	832	10	in	in	IN
cord-259603-bh198xgl	832	11	vivo	vivo	NN
cord-259603-bh198xgl	832	12	function	function	NN
cord-259603-bh198xgl	832	13	that	that	WDT
cord-259603-bh198xgl	832	14	remains	remain	VBZ
cord-259603-bh198xgl	832	15	to	to	TO
cord-259603-bh198xgl	832	16	be	be	VB
cord-259603-bh198xgl	832	17	identified	identify	VBN
cord-259603-bh198xgl	832	18	in	in	IN
cord-259603-bh198xgl	832	19	suitable	suitable	JJ
cord-259603-bh198xgl	832	20	model	model	NN
cord-259603-bh198xgl	832	21	systems	system	NNS
cord-259603-bh198xgl	832	22	.	.	.
cord-259603-bh198xgl	833	1	Initial	initial	JJ
cord-259603-bh198xgl	833	2	evidence	evidence	NN
cord-259603-bh198xgl	833	3	for	for	IN
cord-259603-bh198xgl	833	4	specific	specific	JJ
cord-259603-bh198xgl	833	5	functions	function	NNS
cord-259603-bh198xgl	833	6	of	of	IN
cord-259603-bh198xgl	833	7	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	833	8	endoU	endoU	NNP
cord-259603-bh198xgl	833	9	domains	domain	NNS
cord-259603-bh198xgl	833	10	in	in	IN
cord-259603-bh198xgl	833	11	infected	infected	JJ
cord-259603-bh198xgl	833	12	cells	cell	NNS
cord-259603-bh198xgl	833	13	was	be	VBD
cord-259603-bh198xgl	833	14	obtained	obtain	VBN
cord-259603-bh198xgl	833	15	in	in	IN
cord-259603-bh198xgl	833	16	studies	study	NNS
cord-259603-bh198xgl	833	17	showing	show	VBG
cord-259603-bh198xgl	833	18	that	that	IN
cord-259603-bh198xgl	833	19	SARS	SARS	NNP
cord-259603-bh198xgl	833	20	-	-	HYPH
cord-259603-bh198xgl	833	21	CoV	CoV	NNP
cord-259603-bh198xgl	833	22	nsp15	nsp15	CD
cord-259603-bh198xgl	833	23	,	,	,
cord-259603-bh198xgl	833	24	but	but	CC
cord-259603-bh198xgl	833	25	surprisingly	surprisingly	RB
cord-259603-bh198xgl	833	26	not	not	RB
cord-259603-bh198xgl	833	27	the	the	DT
cord-259603-bh198xgl	833	28	homologous	homologous	JJ
cord-259603-bh198xgl	833	29	proteins	protein	NNS
cord-259603-bh198xgl	833	30	from	from	IN
cord-259603-bh198xgl	833	31	HCoV	HCoV	NNP
cord-259603-bh198xgl	833	32	-	-	HYPH
cord-259603-bh198xgl	833	33	NL63	NL63	NNP
cord-259603-bh198xgl	833	34	and	and	CC
cord-259603-bh198xgl	833	35	HCoV	HCoV	NNP
cord-259603-bh198xgl	833	36	-	-	HYPH
cord-259603-bh198xgl	833	37	HKU1	HKU1	NNP
cord-259603-bh198xgl	833	38	,	,	,
cord-259603-bh198xgl	833	39	counteracts	counteract	VBZ
cord-259603-bh198xgl	833	40	MAVS	mavs	RB
cord-259603-bh198xgl	833	41	-	-	HYPH
cord-259603-bh198xgl	833	42	induced	induce	VBN
cord-259603-bh198xgl	833	43	apoptosis	apoptosis	NN
cord-259603-bh198xgl	833	44	(	(	-LRB-
cord-259603-bh198xgl	833	45	Lei	Lei	NNP
cord-259603-bh198xgl	833	46	et	et	FW
cord-259603-bh198xgl	833	47	al	al	NNP
cord-259603-bh198xgl	833	48	.	.	NNP
cord-259603-bh198xgl	833	49	,	,	,
cord-259603-bh198xgl	833	50	2009	2009	CD
cord-259603-bh198xgl	833	51	)	)	-RRB-
cord-259603-bh198xgl	833	52	.	.	.
cord-259603-bh198xgl	834	1	Further	further	JJ
cord-259603-bh198xgl	834	2	experiments	experiment	NNS
cord-259603-bh198xgl	834	3	will	will	MD
cord-259603-bh198xgl	834	4	be	be	VB
cord-259603-bh198xgl	834	5	necessary	necessary	JJ
cord-259603-bh198xgl	834	6	to	to	TO
cord-259603-bh198xgl	834	7	confirm	confirm	VB
cord-259603-bh198xgl	834	8	and	and	CC
cord-259603-bh198xgl	834	9	assess	assess	VB
cord-259603-bh198xgl	834	10	the	the	DT
cord-259603-bh198xgl	834	11	significance	significance	NN
cord-259603-bh198xgl	834	12	of	of	IN
cord-259603-bh198xgl	834	13	these	these	DT
cord-259603-bh198xgl	834	14	functions	function	NNS
cord-259603-bh198xgl	834	15	for	for	IN
cord-259603-bh198xgl	834	16	virus	virus	NN
cord-259603-bh198xgl	834	17	replication	replication	NN
cord-259603-bh198xgl	834	18	and/or	and/or	CC
cord-259603-bh198xgl	834	19	virus	virus	NN
cord-259603-bh198xgl	834	20	-	-	HYPH
cord-259603-bh198xgl	834	21	host	host	NN
cord-259603-bh198xgl	834	22	interactions	interaction	NNS
cord-259603-bh198xgl	834	23	.	.	.
cord-259603-bh198xgl	835	1	Nidovirus	Nidovirus	NNP
cord-259603-bh198xgl	835	2	-	-	HYPH
cord-259603-bh198xgl	835	3	encoded	encode	VBN
cord-259603-bh198xgl	835	4	endoU	endoU	NNP
cord-259603-bh198xgl	835	5	activities	activity	NNS
cord-259603-bh198xgl	835	6	have	have	VBP
cord-259603-bh198xgl	835	7	been	be	VBN
cord-259603-bh198xgl	835	8	characterized	characterize	VBN
cord-259603-bh198xgl	835	9	using	use	VBG
cord-259603-bh198xgl	835	10	recombinant	recombinant	JJ
cord-259603-bh198xgl	835	11	forms	form	NNS
cord-259603-bh198xgl	835	12	of	of	IN
cord-259603-bh198xgl	835	13	CoV	cov	NN
cord-259603-bh198xgl	836	1	nsp15	nsp15	NNP
cord-259603-bh198xgl	837	1	(	(	-LRB-
cord-259603-bh198xgl	837	2	SARS	SARS	NNP
cord-259603-bh198xgl	837	3	-	-	HYPH
cord-259603-bh198xgl	837	4	CoV	CoV	NNP
cord-259603-bh198xgl	837	5	,	,	,
cord-259603-bh198xgl	837	6	HCoV-229E	HCoV-229E	NNP
cord-259603-bh198xgl	837	7	,	,	,
cord-259603-bh198xgl	837	8	MHV	MHV	NNP
cord-259603-bh198xgl	837	9	-	-	HYPH
cord-259603-bh198xgl	837	10	A59	A59	NNP
cord-259603-bh198xgl	837	11	,	,	,
cord-259603-bh198xgl	837	12	IBV	IBV	NNP
cord-259603-bh198xgl	837	13	)	)	-RRB-
cord-259603-bh198xgl	837	14	and	and	CC
cord-259603-bh198xgl	838	1	arterivirus	arterivirus	NNP
cord-259603-bh198xgl	838	2	nsp11	nsp11	NNP
cord-259603-bh198xgl	838	3	(	(	-LRB-
cord-259603-bh198xgl	838	4	EAV	EAV	NNP
cord-259603-bh198xgl	838	5	,	,	,
cord-259603-bh198xgl	838	6	PRRSV	PRRSV	NNP
cord-259603-bh198xgl	838	7	)	)	-RRB-
cord-259603-bh198xgl	839	1	(	(	-LRB-
cord-259603-bh198xgl	839	2	Bhardwaj	Bhardwaj	NNP
cord-259603-bh198xgl	839	3	et	et	NNP
cord-259603-bh198xgl	839	4	al	al	NNP
cord-259603-bh198xgl	839	5	.	.	NNP
cord-259603-bh198xgl	839	6	,	,	,
cord-259603-bh198xgl	839	7	2004	2004	CD
cord-259603-bh198xgl	840	1	;	;	:
cord-259603-bh198xgl	840	2	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	840	3	et	et	NNP
cord-259603-bh198xgl	840	4	al	al	NNP
cord-259603-bh198xgl	840	5	.	.	.
cord-259603-bh198xgl	841	1	,	,	,
cord-259603-bh198xgl	841	2	2004a	2004a	CD
cord-259603-bh198xgl	841	3	;	;	:
cord-259603-bh198xgl	841	4	Kang	Kang	NNP
cord-259603-bh198xgl	841	5	et	et	NNP
cord-259603-bh198xgl	841	6	al	al	NNP
cord-259603-bh198xgl	841	7	.	.	NNP
cord-259603-bh198xgl	841	8	,	,	,
cord-259603-bh198xgl	841	9	2007	2007	CD
cord-259603-bh198xgl	841	10	;	;	:
cord-259603-bh198xgl	841	11	Nedialkova	Nedialkova	NNP
cord-259603-bh198xgl	841	12	et	et	NNP
cord-259603-bh198xgl	841	13	al	al	NNP
cord-259603-bh198xgl	841	14	.	.	NNP
cord-259603-bh198xgl	841	15	,	,	,
cord-259603-bh198xgl	841	16	2009	2009	CD
cord-259603-bh198xgl	841	17	)	)	-RRB-
cord-259603-bh198xgl	841	18	.	.	.
cord-259603-bh198xgl	842	1	In	in	IN
cord-259603-bh198xgl	842	2	a	a	DT
cord-259603-bh198xgl	842	3	number	number	NN
cord-259603-bh198xgl	842	4	of	of	IN
cord-259603-bh198xgl	842	5	studies	study	NNS
cord-259603-bh198xgl	842	6	,	,	,
cord-259603-bh198xgl	842	7	recombinant	recombinant	JJ
cord-259603-bh198xgl	842	8	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	842	9	endoUs	endoUs	NNP
cord-259603-bh198xgl	842	10	were	be	VBD
cord-259603-bh198xgl	842	11	shown	show	VBN
cord-259603-bh198xgl	842	12	(	(	-LRB-
cord-259603-bh198xgl	842	13	i	i	NN
cord-259603-bh198xgl	842	14	)	)	-RRB-
cord-259603-bh198xgl	842	15	to	to	TO
cord-259603-bh198xgl	842	16	have	have	VB
cord-259603-bh198xgl	842	17	endonucleolytic	endonucleolytic	JJ
cord-259603-bh198xgl	842	18	activity	activity	NN
cord-259603-bh198xgl	842	19	,	,	,
cord-259603-bh198xgl	842	20	(	(	-LRB-
cord-259603-bh198xgl	842	21	ii	ii	NN
cord-259603-bh198xgl	842	22	)	)	-RRB-
cord-259603-bh198xgl	842	23	to	to	TO
cord-259603-bh198xgl	842	24	cleave	cleave	VB
cord-259603-bh198xgl	842	25	3	3	CD
cord-259603-bh198xgl	842	26	0	0	CD
cord-259603-bh198xgl	842	27	of	of	IN
cord-259603-bh198xgl	842	28	pyrimidines	pyrimidine	NNS
cord-259603-bh198xgl	842	29	,	,	,
cord-259603-bh198xgl	842	30	preferring	prefer	VBG
cord-259603-bh198xgl	842	31	uridine	uridine	NN
cord-259603-bh198xgl	842	32	over	over	IN
cord-259603-bh198xgl	842	33	cytidine	cytidine	NNP
cord-259603-bh198xgl	842	34	,	,	,
cord-259603-bh198xgl	842	35	and	and	CC
cord-259603-bh198xgl	842	36	(	(	-LRB-
cord-259603-bh198xgl	842	37	iii	iii	NN
cord-259603-bh198xgl	842	38	)	)	-RRB-
cord-259603-bh198xgl	842	39	to	to	TO
cord-259603-bh198xgl	842	40	release	release	VB
cord-259603-bh198xgl	842	41	reaction	reaction	NN
cord-259603-bh198xgl	842	42	products	product	NNS
cord-259603-bh198xgl	842	43	with	with	IN
cord-259603-bh198xgl	842	44	2	2	CD
cord-259603-bh198xgl	842	45	0	0	CD
cord-259603-bh198xgl	842	46	,	,	,
cord-259603-bh198xgl	842	47	3	3	CD
cord-259603-bh198xgl	842	48	0	0	CD
cord-259603-bh198xgl	842	49	-cyclic	-cyclic	JJ
cord-259603-bh198xgl	842	50	phosphate	phosphate	NN
cord-259603-bh198xgl	842	51	and	and	CC
cord-259603-bh198xgl	842	52	5	5	CD
cord-259603-bh198xgl	842	53	0	0	CD
cord-259603-bh198xgl	842	54	-OH	-oh	NN
cord-259603-bh198xgl	842	55	ends	end	NNS
cord-259603-bh198xgl	842	56	.	.	.
cord-259603-bh198xgl	843	1	Using	use	VBG
cord-259603-bh198xgl	843	2	suitable	suitable	JJ
cord-259603-bh198xgl	843	3	test	test	NN
cord-259603-bh198xgl	843	4	substrates	substrate	NNS
cord-259603-bh198xgl	843	5	,	,	,
cord-259603-bh198xgl	843	6	RNA	RNA	NNP
cord-259603-bh198xgl	843	7	structural	structural	JJ
cord-259603-bh198xgl	843	8	features	feature	NNS
cord-259603-bh198xgl	843	9	were	be	VBD
cord-259603-bh198xgl	843	10	shown	show	VBN
cord-259603-bh198xgl	843	11	to	to	TO
cord-259603-bh198xgl	843	12	affect	affect	VB
cord-259603-bh198xgl	843	13	endoU	endou	NN
cord-259603-bh198xgl	843	14	cleavage	cleavage	NN
cord-259603-bh198xgl	843	15	efficiency	efficiency	NN
cord-259603-bh198xgl	843	16	,	,	,
cord-259603-bh198xgl	843	17	with	with	IN
cord-259603-bh198xgl	843	18	unpaired	unpaired	JJ
cord-259603-bh198xgl	843	19	pyrimidines	pyrimidine	NNS
cord-259603-bh198xgl	843	20	being	be	VBG
cord-259603-bh198xgl	843	21	processed	process	VBN
cord-259603-bh198xgl	843	22	more	more	RBR
cord-259603-bh198xgl	843	23	efficiently	efficiently	RB
cord-259603-bh198xgl	844	1	(	(	-LRB-
cord-259603-bh198xgl	844	2	Bhardwaj	Bhardwaj	NNP
cord-259603-bh198xgl	844	3	et	et	NNP
cord-259603-bh198xgl	844	4	al	al	NNP
cord-259603-bh198xgl	844	5	.	.	NNP
cord-259603-bh198xgl	844	6	,	,	,
cord-259603-bh198xgl	844	7	2006	2006	CD
cord-259603-bh198xgl	845	1	;	;	:
cord-259603-bh198xgl	845	2	Nedialkova	Nedialkova	NNP
cord-259603-bh198xgl	845	3	et	et	NNP
cord-259603-bh198xgl	845	4	al	al	NNP
cord-259603-bh198xgl	845	5	.	.	NNP
cord-259603-bh198xgl	845	6	,	,	,
cord-259603-bh198xgl	845	7	2009	2009	CD
cord-259603-bh198xgl	845	8	)	)	-RRB-
cord-259603-bh198xgl	845	9	.	.	.
cord-259603-bh198xgl	846	1	The	the	DT
cord-259603-bh198xgl	846	2	role	role	NN
cord-259603-bh198xgl	846	3	of	of	IN
cord-259603-bh198xgl	846	4	metal	metal	NN
cord-259603-bh198xgl	846	5	ions	ion	NNS
cord-259603-bh198xgl	846	6	in	in	IN
cord-259603-bh198xgl	846	7	endoU	endoU	NNP
cord-259603-bh198xgl	846	8	activity	activity	NN
cord-259603-bh198xgl	846	9	is	be	VBZ
cord-259603-bh198xgl	846	10	not	not	RB
cord-259603-bh198xgl	846	11	entirely	entirely	RB
cord-259603-bh198xgl	846	12	clear	clear	JJ
cord-259603-bh198xgl	846	13	,	,	,
cord-259603-bh198xgl	846	14	with	with	IN
cord-259603-bh198xgl	846	15	somewhat	somewhat	RB
cord-259603-bh198xgl	846	16	contradictory	contradictory	JJ
cord-259603-bh198xgl	846	17	data	datum	NNS
cord-259603-bh198xgl	846	18	being	be	VBG
cord-259603-bh198xgl	846	19	reported	report	VBN
cord-259603-bh198xgl	846	20	for	for	IN
cord-259603-bh198xgl	846	21	different	different	JJ
cord-259603-bh198xgl	846	22	homologs	homolog	NNS
cord-259603-bh198xgl	846	23	.	.	.
cord-259603-bh198xgl	847	1	While	while	IN
cord-259603-bh198xgl	847	2	the	the	DT
cord-259603-bh198xgl	847	3	activities	activity	NNS
cord-259603-bh198xgl	847	4	of	of	IN
cord-259603-bh198xgl	847	5	cellular	cellular	JJ
cord-259603-bh198xgl	847	6	and	and	CC
cord-259603-bh198xgl	847	7	CoV	cov	NN
cord-259603-bh198xgl	847	8	homologs	homolog	NNS
cord-259603-bh198xgl	847	9	were	be	VBD
cord-259603-bh198xgl	847	10	shown	show	VBN
cord-259603-bh198xgl	847	11	to	to	TO
cord-259603-bh198xgl	847	12	require	require	VB
cord-259603-bh198xgl	847	13	(	(	-LRB-
cord-259603-bh198xgl	847	14	or	or	CC
cord-259603-bh198xgl	847	15	to	to	TO
cord-259603-bh198xgl	847	16	be	be	VB
cord-259603-bh198xgl	847	17	significantly	significantly	RB
cord-259603-bh198xgl	847	18	stimulated	stimulate	VBN
cord-259603-bh198xgl	847	19	by	by	IN
cord-259603-bh198xgl	847	20	)	)	-RRB-
cord-259603-bh198xgl	847	21	Mn	Mn	NNP
cord-259603-bh198xgl	847	22	2	2	CD
cord-259603-bh198xgl	847	23	+	+	SYM
cord-259603-bh198xgl	847	24	ions	ion	NNS
cord-259603-bh198xgl	848	1	(	(	-LRB-
cord-259603-bh198xgl	848	2	Bhardwaj	Bhardwaj	NNP
cord-259603-bh198xgl	848	3	et	et	NNP
cord-259603-bh198xgl	848	4	al	al	NNP
cord-259603-bh198xgl	848	5	.	.	NNP
cord-259603-bh198xgl	848	6	,	,	,
cord-259603-bh198xgl	848	7	2004	2004	CD
cord-259603-bh198xgl	849	1	;	;	:
cord-259603-bh198xgl	849	2	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	849	3	et	et	NNP
cord-259603-bh198xgl	849	4	al	al	NNP
cord-259603-bh198xgl	849	5	.	.	.
cord-259603-bh198xgl	850	1	,	,	,
cord-259603-bh198xgl	850	2	2004a	2004a	CD
cord-259603-bh198xgl	850	3	;	;	:
cord-259603-bh198xgl	850	4	Laneve	Laneve	NNP
cord-259603-bh198xgl	850	5	et	et	NNP
cord-259603-bh198xgl	850	6	al	al	NNP
cord-259603-bh198xgl	850	7	.	.	NNP
cord-259603-bh198xgl	850	8	,	,	,
cord-259603-bh198xgl	850	9	2003	2003	CD
cord-259603-bh198xgl	851	1	Laneve	Laneve	NNP
cord-259603-bh198xgl	851	2	et	et	NNP
cord-259603-bh198xgl	851	3	al	al	NNP
cord-259603-bh198xgl	851	4	.	.	.
cord-259603-bh198xgl	852	1	,	,	,
cord-259603-bh198xgl	852	2	,	,	,
cord-259603-bh198xgl	852	3	2008	2008	CD
cord-259603-bh198xgl	852	4	,	,	,
cord-259603-bh198xgl	852	5	arterivirus	arterivirus	NNP
cord-259603-bh198xgl	852	6	endoU	endoU	NNP
cord-259603-bh198xgl	852	7	activities	activity	NNS
cord-259603-bh198xgl	852	8	proved	prove	VBD
cord-259603-bh198xgl	852	9	to	to	TO
cord-259603-bh198xgl	852	10	be	be	VB
cord-259603-bh198xgl	852	11	less	less	RBR
cord-259603-bh198xgl	852	12	dependent	dependent	JJ
cord-259603-bh198xgl	852	13	on	on	IN
cord-259603-bh198xgl	852	14	metal	metal	NN
cord-259603-bh198xgl	852	15	ions	ion	NNS
cord-259603-bh198xgl	852	16	.	.	.
cord-259603-bh198xgl	853	1	Low	low	JJ
cord-259603-bh198xgl	853	2	concentrations	concentration	NNS
cord-259603-bh198xgl	853	3	of	of	IN
cord-259603-bh198xgl	853	4	Mn	Mn	NNP
cord-259603-bh198xgl	853	5	2	2	CD
cord-259603-bh198xgl	853	6	+	+	SYM
cord-259603-bh198xgl	853	7	were	be	VBD
cord-259603-bh198xgl	853	8	found	find	VBN
cord-259603-bh198xgl	853	9	to	to	TO
cord-259603-bh198xgl	853	10	stimulate	stimulate	VB
cord-259603-bh198xgl	853	11	only	only	RB
cord-259603-bh198xgl	853	12	marginally	marginally	RB
cord-259603-bh198xgl	853	13	the	the	DT
cord-259603-bh198xgl	853	14	arterivirus	arterivirus	NN
cord-259603-bh198xgl	853	15	endoU	endoU	NNP
cord-259603-bh198xgl	853	16	activities	activity	NNS
cord-259603-bh198xgl	853	17	,	,	,
cord-259603-bh198xgl	853	18	whereas	whereas	IN
cord-259603-bh198xgl	853	19	higher	high	JJR
cord-259603-bh198xgl	853	20	concentrations	concentration	NNS
cord-259603-bh198xgl	853	21	(	(	-LRB-
cord-259603-bh198xgl	853	22	previously	previously	RB
cord-259603-bh198xgl	853	23	shown	show	VBN
cord-259603-bh198xgl	853	24	to	to	TO
cord-259603-bh198xgl	853	25	be	be	VB
cord-259603-bh198xgl	853	26	required	require	VBN
cord-259603-bh198xgl	853	27	for	for	IN
cord-259603-bh198xgl	853	28	optimal	optimal	JJ
cord-259603-bh198xgl	853	29	nucleolytic	nucleolytic	JJ
cord-259603-bh198xgl	853	30	activities	activity	NNS
cord-259603-bh198xgl	853	31	in	in	IN
cord-259603-bh198xgl	853	32	CoV	CoV	NNP
cord-259603-bh198xgl	853	33	and	and	CC
cord-259603-bh198xgl	853	34	cellular	cellular	JJ
cord-259603-bh198xgl	853	35	homologs	homolog	NNS
cord-259603-bh198xgl	853	36	)	)	-RRB-
cord-259603-bh198xgl	853	37	inhibited	inhibit	VBD
cord-259603-bh198xgl	853	38	the	the	DT
cord-259603-bh198xgl	853	39	activities	activity	NNS
cord-259603-bh198xgl	853	40	of	of	IN
cord-259603-bh198xgl	853	41	EAV	EAV	NNP
cord-259603-bh198xgl	853	42	and	and	CC
cord-259603-bh198xgl	853	43	PRRSV	PRRSV	NNP
cord-259603-bh198xgl	853	44	endoUs	endoUs	NNP
cord-259603-bh198xgl	854	1	(	(	-LRB-
cord-259603-bh198xgl	854	2	Nedialkova	Nedialkova	NNP
cord-259603-bh198xgl	854	3	et	et	NNP
cord-259603-bh198xgl	854	4	al	al	NNP
cord-259603-bh198xgl	854	5	.	.	NNP
cord-259603-bh198xgl	854	6	,	,	,
cord-259603-bh198xgl	854	7	2009	2009	CD
cord-259603-bh198xgl	854	8	)	)	-RRB-
cord-259603-bh198xgl	854	9	.	.	.
cord-259603-bh198xgl	855	1	Metal	metal	NN
cord-259603-bh198xgl	855	2	ion	ion	NN
cord-259603-bh198xgl	855	3	requirements	requirement	NNS
cord-259603-bh198xgl	855	4	are	be	VBP
cord-259603-bh198xgl	855	5	commonly	commonly	RB
cord-259603-bh198xgl	855	6	used	use	VBN
cord-259603-bh198xgl	855	7	to	to	TO
cord-259603-bh198xgl	855	8	distinguish	distinguish	VB
cord-259603-bh198xgl	855	9	between	between	IN
cord-259603-bh198xgl	855	10	the	the	DT
cord-259603-bh198xgl	855	11	two	two	CD
cord-259603-bh198xgl	855	12	basic	basic	JJ
cord-259603-bh198xgl	855	13	catalytic	catalytic	JJ
cord-259603-bh198xgl	855	14	mechanisms	mechanism	NNS
cord-259603-bh198xgl	855	15	employed	employ	VBN
cord-259603-bh198xgl	855	16	by	by	IN
cord-259603-bh198xgl	855	17	ribonucleases	ribonuclease	NNS
cord-259603-bh198xgl	855	18	:	:	:
cord-259603-bh198xgl	855	19	the	the	DT
cord-259603-bh198xgl	855	20	metal	metal	NN
cord-259603-bh198xgl	855	21	-	-	HYPH
cord-259603-bh198xgl	855	22	independent	independent	JJ
cord-259603-bh198xgl	855	23	mechanism	mechanism	NN
cord-259603-bh198xgl	855	24	that	that	WDT
cord-259603-bh198xgl	855	25	,	,	,
cord-259603-bh198xgl	855	26	for	for	IN
cord-259603-bh198xgl	855	27	example	example	NN
cord-259603-bh198xgl	855	28	,	,	,
cord-259603-bh198xgl	855	29	is	be	VBZ
cord-259603-bh198xgl	855	30	employed	employ	VBN
cord-259603-bh198xgl	855	31	by	by	IN
cord-259603-bh198xgl	855	32	RNase	RNase	NNP
cord-259603-bh198xgl	855	33	A	A	NNP
cord-259603-bh198xgl	855	34	and	and	CC
cord-259603-bh198xgl	855	35	results	result	VBZ
cord-259603-bh198xgl	855	36	in	in	IN
cord-259603-bh198xgl	855	37	products	product	NNS
cord-259603-bh198xgl	855	38	with	with	IN
cord-259603-bh198xgl	855	39	2	2	CD
cord-259603-bh198xgl	855	40	0	0	CD
cord-259603-bh198xgl	855	41	,	,	,
cord-259603-bh198xgl	855	42	3	3	CD
cord-259603-bh198xgl	855	43	0cyclic	0cyclic	JJ
cord-259603-bh198xgl	855	44	phosphate	phosphate	NN
cord-259603-bh198xgl	855	45	ends	end	NNS
cord-259603-bh198xgl	855	46	(	(	-LRB-
cord-259603-bh198xgl	855	47	as	as	IN
cord-259603-bh198xgl	855	48	described	describe	VBN
cord-259603-bh198xgl	855	49	earlier	early	RBR
cord-259603-bh198xgl	855	50	for	for	IN
cord-259603-bh198xgl	855	51	endoU	endoU	NNP
cord-259603-bh198xgl	855	52	)	)	-RRB-
cord-259603-bh198xgl	855	53	,	,	,
cord-259603-bh198xgl	855	54	and	and	CC
cord-259603-bh198xgl	855	55	the	the	DT
cord-259603-bh198xgl	855	56	metaldependent	metaldependent	NNP
cord-259603-bh198xgl	855	57	mechanism	mechanism	NN
cord-259603-bh198xgl	855	58	in	in	IN
cord-259603-bh198xgl	855	59	which	which	WDT
cord-259603-bh198xgl	855	60	catalysis	catalysis	NN
cord-259603-bh198xgl	855	61	is	be	VBZ
cord-259603-bh198xgl	855	62	aided	aid	VBN
cord-259603-bh198xgl	855	63	by	by	IN
cord-259603-bh198xgl	855	64	two	two	CD
cord-259603-bh198xgl	855	65	divalent	divalent	JJ
cord-259603-bh198xgl	855	66	cations	cation	NNS
cord-259603-bh198xgl	855	67	coordinated	coordinate	VBN
cord-259603-bh198xgl	855	68	by	by	IN
cord-259603-bh198xgl	855	69	conserved	conserved	JJ
cord-259603-bh198xgl	855	70	acidic	acidic	JJ
cord-259603-bh198xgl	855	71	residues	residue	NNS
cord-259603-bh198xgl	855	72	and	and	CC
cord-259603-bh198xgl	855	73	generates	generate	VBZ
cord-259603-bh198xgl	855	74	products	product	NNS
cord-259603-bh198xgl	855	75	with	with	IN
cord-259603-bh198xgl	855	76	3	3	CD
cord-259603-bh198xgl	855	77	0	0	CD
cord-259603-bh198xgl	855	78	-OH	-oh	NN
cord-259603-bh198xgl	855	79	and	and	CC
cord-259603-bh198xgl	855	80	5	5	CD
cord-259603-bh198xgl	855	81	0	0	CD
cord-259603-bh198xgl	855	82	-phosphate	-phosphate	NN
cord-259603-bh198xgl	855	83	ends	end	NNS
cord-259603-bh198xgl	855	84	(	(	-LRB-
cord-259603-bh198xgl	855	85	as	as	IN
cord-259603-bh198xgl	855	86	described	describe	VBN
cord-259603-bh198xgl	855	87	earlier	early	RBR
cord-259603-bh198xgl	855	88	for	for	IN
cord-259603-bh198xgl	855	89	ExoN	ExoN	NNP
cord-259603-bh198xgl	855	90	)	)	-RRB-
cord-259603-bh198xgl	855	91	.	.	.
cord-259603-bh198xgl	856	1	The	the	DT
cord-259603-bh198xgl	856	2	critical	critical	JJ
cord-259603-bh198xgl	856	3	(	(	-LRB-
cord-259603-bh198xgl	856	4	or	or	CC
cord-259603-bh198xgl	856	5	supportive	supportive	JJ
cord-259603-bh198xgl	856	6	)	)	-RRB-
cord-259603-bh198xgl	856	7	role	role	NN
cord-259603-bh198xgl	856	8	of	of	IN
cord-259603-bh198xgl	856	9	metal	metal	NN
cord-259603-bh198xgl	856	10	ions	ion	NNS
cord-259603-bh198xgl	856	11	observed	observe	VBN
cord-259603-bh198xgl	856	12	for	for	IN
cord-259603-bh198xgl	856	13	several	several	JJ
cord-259603-bh198xgl	856	14	cellular	cellular	JJ
cord-259603-bh198xgl	856	15	and	and	CC
cord-259603-bh198xgl	856	16	viral	viral	JJ
cord-259603-bh198xgl	856	17	endoU	endoU	NNP
cord-259603-bh198xgl	856	18	homologs	homolog	NNS
cord-259603-bh198xgl	856	19	is	be	VBZ
cord-259603-bh198xgl	856	20	inconsistent	inconsistent	JJ
cord-259603-bh198xgl	856	21	with	with	IN
cord-259603-bh198xgl	856	22	an	an	DT
cord-259603-bh198xgl	856	23	RNase	RNase	NNP
cord-259603-bh198xgl	856	24	A	a	NN
cord-259603-bh198xgl	856	25	-	-	HYPH
cord-259603-bh198xgl	856	26	like	like	JJ
cord-259603-bh198xgl	856	27	(	(	-LRB-
cord-259603-bh198xgl	856	28	metal	metal	NN
cord-259603-bh198xgl	856	29	-	-	HYPH
cord-259603-bh198xgl	856	30	independent	independent	JJ
cord-259603-bh198xgl	856	31	)	)	-RRB-
cord-259603-bh198xgl	856	32	reaction	reaction	NN
cord-259603-bh198xgl	856	33	mechanism	mechanism	NN
cord-259603-bh198xgl	856	34	.	.	.
cord-259603-bh198xgl	857	1	Also	also	RB
cord-259603-bh198xgl	857	2	,	,	,
cord-259603-bh198xgl	857	3	metal	metal	NN
cord-259603-bh198xgl	857	4	ions	ion	NNS
cord-259603-bh198xgl	857	5	were	be	VBD
cord-259603-bh198xgl	857	6	not	not	RB
cord-259603-bh198xgl	857	7	detected	detect	VBN
cord-259603-bh198xgl	857	8	in	in	IN
cord-259603-bh198xgl	857	9	any	any	DT
cord-259603-bh198xgl	857	10	of	of	IN
cord-259603-bh198xgl	857	11	the	the	DT
cord-259603-bh198xgl	857	12	structures	structure	NNS
cord-259603-bh198xgl	857	13	determined	determine	VBN
cord-259603-bh198xgl	857	14	for	for	IN
cord-259603-bh198xgl	857	15	coronavirus	coronavirus	NN
cord-259603-bh198xgl	857	16	nsp15s	nsp15s	NNP
cord-259603-bh198xgl	857	17	or	or	CC
cord-259603-bh198xgl	857	18	XendoU	xendou	NN
cord-259603-bh198xgl	857	19	,	,	,
cord-259603-bh198xgl	857	20	arguing	argue	VBG
cord-259603-bh198xgl	857	21	against	against	IN
cord-259603-bh198xgl	857	22	a	a	DT
cord-259603-bh198xgl	857	23	direct	direct	JJ
cord-259603-bh198xgl	857	24	role	role	NN
cord-259603-bh198xgl	857	25	of	of	IN
cord-259603-bh198xgl	857	26	metal	metal	NN
cord-259603-bh198xgl	857	27	ions	ion	NNS
cord-259603-bh198xgl	857	28	in	in	IN
cord-259603-bh198xgl	857	29	catalysis	catalysis	NN
cord-259603-bh198xgl	857	30	(	(	-LRB-
cord-259603-bh198xgl	857	31	Renzi	Renzi	NNP
cord-259603-bh198xgl	857	32	et	et	NNP
cord-259603-bh198xgl	857	33	al	al	NNP
cord-259603-bh198xgl	857	34	.	.	NNP
cord-259603-bh198xgl	857	35	,	,	,
cord-259603-bh198xgl	857	36	2006	2006	CD
cord-259603-bh198xgl	857	37	;	;	.
cord-259603-bh198xgl	858	1	Ricagno	Ricagno	NNP
cord-259603-bh198xgl	858	2	et	et	FW
cord-259603-bh198xgl	858	3	al	al	NNP
cord-259603-bh198xgl	858	4	.	.	NNP
cord-259603-bh198xgl	858	5	,	,	,
cord-259603-bh198xgl	858	6	2006	2006	CD
cord-259603-bh198xgl	858	7	)	)	-RRB-
cord-259603-bh198xgl	858	8	.	.	.
cord-259603-bh198xgl	859	1	However	however	RB
cord-259603-bh198xgl	859	2	,	,	,
cord-259603-bh198xgl	859	3	Mn	Mn	NNP
cord-259603-bh198xgl	859	4	2	2	CD
cord-259603-bh198xgl	859	5	+	+	SYM
cord-259603-bh198xgl	859	6	ions	ion	NNS
cord-259603-bh198xgl	859	7	were	be	VBD
cord-259603-bh198xgl	859	8	found	find	VBN
cord-259603-bh198xgl	859	9	to	to	TO
cord-259603-bh198xgl	859	10	change	change	VB
cord-259603-bh198xgl	859	11	the	the	DT
cord-259603-bh198xgl	859	12	intrinsic	intrinsic	JJ
cord-259603-bh198xgl	859	13	tryptophan	tryptophan	NN
cord-259603-bh198xgl	859	14	fluorescence	fluorescence	NN
cord-259603-bh198xgl	859	15	of	of	IN
cord-259603-bh198xgl	859	16	SARS	SARS	NNP
cord-259603-bh198xgl	859	17	-	-	HYPH
cord-259603-bh198xgl	859	18	CoV	CoV	NNP
cord-259603-bh198xgl	859	19	nsp15	nsp15	NNP
cord-259603-bh198xgl	859	20	,	,	,
cord-259603-bh198xgl	859	21	suggesting	suggest	VBG
cord-259603-bh198xgl	859	22	conformational	conformational	JJ
cord-259603-bh198xgl	859	23	changes	change	NNS
cord-259603-bh198xgl	859	24	that	that	WDT
cord-259603-bh198xgl	859	25	,	,	,
cord-259603-bh198xgl	859	26	potentially	potentially	RB
cord-259603-bh198xgl	859	27	,	,	,
cord-259603-bh198xgl	859	28	may	may	MD
cord-259603-bh198xgl	859	29	affect	affect	VB
cord-259603-bh198xgl	859	30	activity	activity	NN
cord-259603-bh198xgl	859	31	and	and	CC
cord-259603-bh198xgl	859	32	were	be	VBD
cord-259603-bh198xgl	859	33	shown	show	VBN
cord-259603-bh198xgl	859	34	to	to	TO
cord-259603-bh198xgl	859	35	be	be	VB
cord-259603-bh198xgl	859	36	unrelated	unrelated	JJ
cord-259603-bh198xgl	859	37	to	to	TO
cord-259603-bh198xgl	859	38	protein	protein	VB
cord-259603-bh198xgl	859	39	multimerization	multimerization	NNP
cord-259603-bh198xgl	860	1	(	(	-LRB-
cord-259603-bh198xgl	860	2	Bhardwaj	Bhardwaj	NNP
cord-259603-bh198xgl	860	3	et	et	NNP
cord-259603-bh198xgl	860	4	al	al	NNP
cord-259603-bh198xgl	860	5	.	.	NNP
cord-259603-bh198xgl	860	6	,	,	,
cord-259603-bh198xgl	860	7	2004	2004	CD
cord-259603-bh198xgl	860	8	;	;	:
cord-259603-bh198xgl	860	9	Guarino	Guarino	NNP
cord-259603-bh198xgl	860	10	et	et	NNP
cord-259603-bh198xgl	860	11	al	al	NNP
cord-259603-bh198xgl	860	12	.	.	NNP
cord-259603-bh198xgl	860	13	,	,	,
cord-259603-bh198xgl	860	14	2005	2005	CD
cord-259603-bh198xgl	860	15	)	)	-RRB-
cord-259603-bh198xgl	860	16	.	.	.
cord-259603-bh198xgl	861	1	Also	also	RB
cord-259603-bh198xgl	861	2	,	,	,
cord-259603-bh198xgl	861	3	regarding	regard	VBG
cord-259603-bh198xgl	861	4	the	the	DT
cord-259603-bh198xgl	861	5	role	role	NN
cord-259603-bh198xgl	861	6	of	of	IN
cord-259603-bh198xgl	861	7	Mn	Mn	NNP
cord-259603-bh198xgl	861	8	2	2	CD
cord-259603-bh198xgl	861	9	+	+	SYM
cord-259603-bh198xgl	861	10	in	in	IN
cord-259603-bh198xgl	861	11	RNA	RNA	NNP
cord-259603-bh198xgl	861	12	binding	binding	NN
cord-259603-bh198xgl	861	13	,	,	,
cord-259603-bh198xgl	861	14	contradicting	contradict	VBG
cord-259603-bh198xgl	861	15	data	datum	NNS
cord-259603-bh198xgl	861	16	have	have	VBP
cord-259603-bh198xgl	861	17	been	be	VBN
cord-259603-bh198xgl	861	18	reported	report	VBN
cord-259603-bh198xgl	861	19	,	,	,
cord-259603-bh198xgl	861	20	with	with	IN
cord-259603-bh198xgl	861	21	RNA	RNA	NNP
cord-259603-bh198xgl	861	22	binding	bind	VBG
cord-259603-bh198xgl	861	23	by	by	IN
cord-259603-bh198xgl	861	24	SARS	SARS	NNP
cord-259603-bh198xgl	861	25	-	-	HYPH
cord-259603-bh198xgl	861	26	CoV	CoV	NNP
cord-259603-bh198xgl	861	27	nsp15	nsp15	CD
cord-259603-bh198xgl	861	28	being	be	VBG
cord-259603-bh198xgl	861	29	enhanced	enhance	VBN
cord-259603-bh198xgl	861	30	in	in	IN
cord-259603-bh198xgl	861	31	the	the	DT
cord-259603-bh198xgl	861	32	presence	presence	NN
cord-259603-bh198xgl	861	33	of	of	IN
cord-259603-bh198xgl	861	34	Mn	Mn	NNP
cord-259603-bh198xgl	861	35	2	2	CD
cord-259603-bh198xgl	861	36	+	+	SYM
cord-259603-bh198xgl	861	37	or	or	CC
cord-259603-bh198xgl	861	38	not	not	RB
cord-259603-bh198xgl	861	39	affected	affect	VBN
cord-259603-bh198xgl	861	40	by	by	IN
cord-259603-bh198xgl	861	41	metal	metal	NN
cord-259603-bh198xgl	861	42	ions	ion	NNS
cord-259603-bh198xgl	861	43	in	in	IN
cord-259603-bh198xgl	861	44	the	the	DT
cord-259603-bh198xgl	861	45	case	case	NN
cord-259603-bh198xgl	861	46	of	of	IN
cord-259603-bh198xgl	861	47	XendoU	xendou	NN
cord-259603-bh198xgl	862	1	(	(	-LRB-
cord-259603-bh198xgl	862	2	Bhardwaj	Bhardwaj	NNP
cord-259603-bh198xgl	862	3	et	et	NNP
cord-259603-bh198xgl	862	4	al	al	NNP
cord-259603-bh198xgl	862	5	.	.	NNP
cord-259603-bh198xgl	862	6	,	,	,
cord-259603-bh198xgl	862	7	2006	2006	CD
cord-259603-bh198xgl	862	8	;	;	.
cord-259603-bh198xgl	863	1	Gioia	Gioia	NNP
cord-259603-bh198xgl	863	2	et	et	FW
cord-259603-bh198xgl	863	3	al	al	NNP
cord-259603-bh198xgl	863	4	.	.	NNP
cord-259603-bh198xgl	863	5	,	,	,
cord-259603-bh198xgl	863	6	2005	2005	CD
cord-259603-bh198xgl	863	7	)	)	-RRB-
cord-259603-bh198xgl	863	8	.	.	.
cord-259603-bh198xgl	864	1	Structural	structural	JJ
cord-259603-bh198xgl	864	2	information	information	NN
cord-259603-bh198xgl	864	3	has	have	VBZ
cord-259603-bh198xgl	864	4	been	be	VBN
cord-259603-bh198xgl	864	5	obtained	obtain	VBN
cord-259603-bh198xgl	864	6	by	by	IN
cord-259603-bh198xgl	864	7	X	x	NN
cord-259603-bh198xgl	864	8	-	-	NN
cord-259603-bh198xgl	864	9	ray	ray	NN
cord-259603-bh198xgl	864	10	crystallography	crystallography	NN
cord-259603-bh198xgl	864	11	and	and	CC
cord-259603-bh198xgl	864	12	cryoelectron	cryoelectron	NNP
cord-259603-bh198xgl	864	13	microscopy	microscopy	NNP
cord-259603-bh198xgl	864	14	studies	study	NNS
cord-259603-bh198xgl	864	15	for	for	IN
cord-259603-bh198xgl	864	16	several	several	JJ
cord-259603-bh198xgl	864	17	CoV	cov	NN
cord-259603-bh198xgl	864	18	and	and	CC
cord-259603-bh198xgl	864	19	cellular	cellular	JJ
cord-259603-bh198xgl	864	20	endoU	endoU	NNP
cord-259603-bh198xgl	864	21	homologs	homolog	NNS
cord-259603-bh198xgl	864	22	(	(	-LRB-
cord-259603-bh198xgl	864	23	Bhardwaj	Bhardwaj	NNP
cord-259603-bh198xgl	864	24	et	et	NNP
cord-259603-bh198xgl	864	25	al	al	NNP
cord-259603-bh198xgl	864	26	.	.	NNP
cord-259603-bh198xgl	864	27	,	,	,
cord-259603-bh198xgl	864	28	2008	2008	CD
cord-259603-bh198xgl	864	29	;	;	:
cord-259603-bh198xgl	864	30	Renzi	Renzi	NNP
cord-259603-bh198xgl	864	31	et	et	NNP
cord-259603-bh198xgl	864	32	al	al	NNP
cord-259603-bh198xgl	864	33	.	.	NNP
cord-259603-bh198xgl	864	34	,	,	,
cord-259603-bh198xgl	864	35	2006	2006	CD
cord-259603-bh198xgl	864	36	;	;	.
cord-259603-bh198xgl	865	1	Ricagno	Ricagno	NNP
cord-259603-bh198xgl	865	2	et	et	FW
cord-259603-bh198xgl	865	3	al	al	NNP
cord-259603-bh198xgl	865	4	.	.	NNP
cord-259603-bh198xgl	865	5	,	,	,
cord-259603-bh198xgl	865	6	2006	2006	CD
cord-259603-bh198xgl	866	1	;	;	:
cord-259603-bh198xgl	866	2	Xu	Xu	NNP
cord-259603-bh198xgl	866	3	et	et	NNP
cord-259603-bh198xgl	866	4	al	al	NNP
cord-259603-bh198xgl	866	5	.	.	NNP
cord-259603-bh198xgl	866	6	,	,	,
cord-259603-bh198xgl	866	7	2006	2006	CD
cord-259603-bh198xgl	866	8	)	)	-RRB-
cord-259603-bh198xgl	866	9	.	.	.
cord-259603-bh198xgl	867	1	SARS	SARS	NNP
cord-259603-bh198xgl	867	2	-	-	HYPH
cord-259603-bh198xgl	867	3	CoV	CoV	NNP
cord-259603-bh198xgl	867	4	and	and	CC
cord-259603-bh198xgl	867	5	MHV	MHV	NNP
cord-259603-bh198xgl	867	6	nsp15s	nsp15s	NNPS
cord-259603-bh198xgl	867	7	were	be	VBD
cord-259603-bh198xgl	867	8	shown	show	VBN
cord-259603-bh198xgl	867	9	to	to	TO
cord-259603-bh198xgl	867	10	form	form	VB
cord-259603-bh198xgl	867	11	homohexamers	homohexamer	NNS
cord-259603-bh198xgl	867	12	comprised	comprise	VBN
cord-259603-bh198xgl	867	13	of	of	IN
cord-259603-bh198xgl	867	14	a	a	DT
cord-259603-bh198xgl	867	15	dimer	dimer	NN
cord-259603-bh198xgl	867	16	of	of	IN
cord-259603-bh198xgl	867	17	trimers	trimer	NNS
cord-259603-bh198xgl	867	18	.	.	.
cord-259603-bh198xgl	868	1	The	the	DT
cord-259603-bh198xgl	868	2	nsp15	nsp15	NNP
cord-259603-bh198xgl	868	3	monomers	monomer	NNS
cord-259603-bh198xgl	868	4	have	have	VBP
cord-259603-bh198xgl	868	5	an	an	DT
cord-259603-bh198xgl	868	6	α	α	NN
cord-259603-bh198xgl	868	7	+	+	CC
cord-259603-bh198xgl	868	8	β	β	NN
cord-259603-bh198xgl	868	9	structure	structure	NN
cord-259603-bh198xgl	868	10	with	with	IN
cord-259603-bh198xgl	868	11	three	three	CD
cord-259603-bh198xgl	868	12	subdomains	subdomain	NNS
cord-259603-bh198xgl	868	13	,	,	,
cord-259603-bh198xgl	868	14	a	a	DT
cord-259603-bh198xgl	868	15	small	small	JJ
cord-259603-bh198xgl	868	16	N	n	CD
cord-259603-bh198xgl	868	17	-	-	HYPH
cord-259603-bh198xgl	868	18	terminal	terminal	NN
cord-259603-bh198xgl	868	19	,	,	,
cord-259603-bh198xgl	868	20	an	an	DT
cord-259603-bh198xgl	868	21	intermediate	intermediate	JJ
cord-259603-bh198xgl	868	22	-	-	HYPH
cord-259603-bh198xgl	868	23	sized	sized	JJ
cord-259603-bh198xgl	868	24	middle	middle	NN
cord-259603-bh198xgl	868	25	,	,	,
cord-259603-bh198xgl	868	26	and	and	CC
cord-259603-bh198xgl	868	27	a	a	DT
cord-259603-bh198xgl	868	28	large	large	JJ
cord-259603-bh198xgl	868	29	C	c	NN
cord-259603-bh198xgl	868	30	-	-	HYPH
cord-259603-bh198xgl	868	31	terminal	terminal	NN
cord-259603-bh198xgl	868	32	domain	domain	NN
cord-259603-bh198xgl	868	33	,	,	,
cord-259603-bh198xgl	868	34	the	the	DT
cord-259603-bh198xgl	868	35	latter	latter	JJ
cord-259603-bh198xgl	868	36	basically	basically	RB
cord-259603-bh198xgl	868	37	representing	represent	VBG
cord-259603-bh198xgl	868	38	the	the	DT
cord-259603-bh198xgl	868	39	"	"	``
cord-259603-bh198xgl	868	40	conserved	conserved	JJ
cord-259603-bh198xgl	868	41	domain	domain	NN
cord-259603-bh198xgl	868	42	"	"	''
cord-259603-bh198xgl	868	43	of	of	IN
cord-259603-bh198xgl	868	44	the	the	DT
cord-259603-bh198xgl	868	45	CoV	cov	NN
cord-259603-bh198xgl	868	46	-	-	HYPH
cord-259603-bh198xgl	868	47	like	like	JJ
cord-259603-bh198xgl	868	48	superfamily	superfamily	NN
cord-259603-bh198xgl	868	49	(	(	-LRB-
cord-259603-bh198xgl	868	50	see	see	VB
cord-259603-bh198xgl	868	51	earlier	early	RBR
cord-259603-bh198xgl	868	52	)	)	-RRB-
cord-259603-bh198xgl	868	53	.	.	.
cord-259603-bh198xgl	869	1	One	one	CD
cord-259603-bh198xgl	869	2	side	side	NN
cord-259603-bh198xgl	869	3	of	of	IN
cord-259603-bh198xgl	869	4	this	this	DT
cord-259603-bh198xgl	869	5	domain	domain	NN
cord-259603-bh198xgl	869	6	contains	contain	VBZ
cord-259603-bh198xgl	869	7	two	two	CD
cord-259603-bh198xgl	869	8	β	β	NN
cord-259603-bh198xgl	869	9	-	-	HYPH
cord-259603-bh198xgl	869	10	sheets	sheet	NNS
cord-259603-bh198xgl	869	11	that	that	WDT
cord-259603-bh198xgl	869	12	line	line	VBP
cord-259603-bh198xgl	869	13	the	the	DT
cord-259603-bh198xgl	869	14	positively	positively	RB
cord-259603-bh198xgl	869	15	charged	charge	VBN
cord-259603-bh198xgl	869	16	active	active	JJ
cord-259603-bh198xgl	869	17	-	-	HYPH
cord-259603-bh198xgl	869	18	site	site	NN
cord-259603-bh198xgl	869	19	groove	groove	NN
cord-259603-bh198xgl	869	20	,	,	,
cord-259603-bh198xgl	869	21	while	while	IN
cord-259603-bh198xgl	869	22	the	the	DT
cord-259603-bh198xgl	869	23	other	other	JJ
cord-259603-bh198xgl	869	24	side	side	NN
cord-259603-bh198xgl	869	25	is	be	VBZ
cord-259603-bh198xgl	869	26	formed	form	VBN
cord-259603-bh198xgl	869	27	by	by	IN
cord-259603-bh198xgl	869	28	five	five	CD
cord-259603-bh198xgl	869	29	α	α	NN
cord-259603-bh198xgl	869	30	-	-	HYPH
cord-259603-bh198xgl	869	31	helices	helix	NNS
cord-259603-bh198xgl	869	32	.	.	.
cord-259603-bh198xgl	870	1	The	the	DT
cord-259603-bh198xgl	870	2	structures	structure	NNS
cord-259603-bh198xgl	870	3	of	of	IN
cord-259603-bh198xgl	870	4	the	the	DT
cord-259603-bh198xgl	870	5	catalytic	catalytic	JJ
cord-259603-bh198xgl	870	6	domains	domain	NNS
cord-259603-bh198xgl	870	7	are	be	VBP
cord-259603-bh198xgl	870	8	largely	largely	RB
cord-259603-bh198xgl	870	9	conserved	conserve	VBN
cord-259603-bh198xgl	870	10	among	among	IN
cord-259603-bh198xgl	870	11	CoV	CoV	NNP
cord-259603-bh198xgl	870	12	endoUs	endoUs	NNP
cord-259603-bh198xgl	870	13	and	and	CC
cord-259603-bh198xgl	870	14	XendoU	XendoU	NNP
cord-259603-bh198xgl	870	15	,	,	,
cord-259603-bh198xgl	870	16	supporting	support	VBG
cord-259603-bh198xgl	870	17	the	the	DT
cord-259603-bh198xgl	870	18	proposed	propose	VBN
cord-259603-bh198xgl	870	19	common	common	JJ
cord-259603-bh198xgl	870	20	phylogeny	phylogeny	NN
cord-259603-bh198xgl	870	21	of	of	IN
cord-259603-bh198xgl	870	22	viral	viral	JJ
cord-259603-bh198xgl	870	23	cellular	cellular	JJ
cord-259603-bh198xgl	870	24	members	member	NNS
cord-259603-bh198xgl	870	25	of	of	IN
cord-259603-bh198xgl	870	26	this	this	DT
cord-259603-bh198xgl	870	27	large	large	JJ
cord-259603-bh198xgl	870	28	endoribonuclease	endoribonuclease	NN
cord-259603-bh198xgl	870	29	family	family	NN
cord-259603-bh198xgl	871	1	(	(	-LRB-
cord-259603-bh198xgl	871	2	Bhardwaj	Bhardwaj	NNP
cord-259603-bh198xgl	871	3	et	et	NNP
cord-259603-bh198xgl	871	4	al	al	NNP
cord-259603-bh198xgl	871	5	.	.	NNP
cord-259603-bh198xgl	871	6	,	,	,
cord-259603-bh198xgl	871	7	2008	2008	CD
cord-259603-bh198xgl	872	1	;	;	:
cord-259603-bh198xgl	872	2	Renzi	Renzi	NNP
cord-259603-bh198xgl	872	3	et	et	NNP
cord-259603-bh198xgl	872	4	al	al	NNP
cord-259603-bh198xgl	872	5	.	.	NNP
cord-259603-bh198xgl	872	6	,	,	,
cord-259603-bh198xgl	872	7	2006	2006	CD
cord-259603-bh198xgl	872	8	;	;	:
cord-259603-bh198xgl	872	9	Snijder	Snijder	NNP
cord-259603-bh198xgl	872	10	et	et	NNP
cord-259603-bh198xgl	872	11	al	al	NNP
cord-259603-bh198xgl	872	12	.	.	NNP
cord-259603-bh198xgl	872	13	,	,	,
cord-259603-bh198xgl	872	14	2003	2003	CD
cord-259603-bh198xgl	872	15	)	)	-RRB-
cord-259603-bh198xgl	872	16	.	.	.
cord-259603-bh198xgl	873	1	The	the	DT
cord-259603-bh198xgl	873	2	endoU	endoU	NNP
cord-259603-bh198xgl	873	3	hexamer	hexamer	NN
cord-259603-bh198xgl	873	4	reported	report	VBD
cord-259603-bh198xgl	873	5	for	for	IN
cord-259603-bh198xgl	873	6	SARS	SARS	NNP
cord-259603-bh198xgl	873	7	-	-	HYPH
cord-259603-bh198xgl	873	8	CoV	CoV	NNP
cord-259603-bh198xgl	874	1	nsp15	nsp15	NNP
cord-259603-bh198xgl	875	1	(	(	-LRB-
cord-259603-bh198xgl	875	2	Ricagno	Ricagno	NNP
cord-259603-bh198xgl	875	3	et	et	FW
cord-259603-bh198xgl	875	4	al	al	NNP
cord-259603-bh198xgl	875	5	.	.	NNP
cord-259603-bh198xgl	875	6	,	,	,
cord-259603-bh198xgl	875	7	2006	2006	CD
cord-259603-bh198xgl	875	8	)	)	-RRB-
cord-259603-bh198xgl	875	9	has	have	VBZ
cord-259603-bh198xgl	875	10	dimensions	dimension	NNS
cord-259603-bh198xgl	875	11	of	of	IN
cord-259603-bh198xgl	875	12	80	80	CD
cord-259603-bh198xgl	875	13	-	-	SYM
cord-259603-bh198xgl	875	14	96	96	CD
cord-259603-bh198xgl	875	15	Â	â	CD
cord-259603-bh198xgl	875	16	110	110	CD
cord-259603-bh198xgl	875	17	Å	å	NN
cord-259603-bh198xgl	875	18	,	,	,
cord-259603-bh198xgl	875	19	forming	form	VBG
cord-259603-bh198xgl	875	20	a	a	DT
cord-259603-bh198xgl	875	21	three	three	CD
cord-259603-bh198xgl	875	22	-	-	HYPH
cord-259603-bh198xgl	875	23	petal	petal	NN
cord-259603-bh198xgl	875	24	-	-	HYPH
cord-259603-bh198xgl	875	25	shaped	shape	VBN
cord-259603-bh198xgl	875	26	surface	surface	NN
cord-259603-bh198xgl	875	27	that	that	WDT
cord-259603-bh198xgl	875	28	surrounds	surround	VBZ
cord-259603-bh198xgl	875	29	a	a	DT
cord-259603-bh198xgl	875	30	small	small	JJ
cord-259603-bh198xgl	875	31	,	,	,
cord-259603-bh198xgl	875	32	predominantly	predominantly	RB
cord-259603-bh198xgl	875	33	negatively	negatively	RB
cord-259603-bh198xgl	875	34	charged	charge	VBN
cord-259603-bh198xgl	875	35	central	central	JJ
cord-259603-bh198xgl	875	36	channel	channel	NN
cord-259603-bh198xgl	875	37	with	with	IN
cord-259603-bh198xgl	875	38	an	an	DT
cord-259603-bh198xgl	875	39	inner	inner	JJ
cord-259603-bh198xgl	875	40	diameter	diameter	NN
cord-259603-bh198xgl	875	41	of	of	IN
cord-259603-bh198xgl	875	42	$	$	$
cord-259603-bh198xgl	875	43	15	15	CD
cord-259603-bh198xgl	875	44	Å	å	NN
cord-259603-bh198xgl	875	45	.	.	.
cord-259603-bh198xgl	876	1	The	the	DT
cord-259603-bh198xgl	876	2	hexamer	hexamer	NN
cord-259603-bh198xgl	876	3	has	have	VBZ
cord-259603-bh198xgl	876	4	six	six	CD
cord-259603-bh198xgl	876	5	-	-	HYPH
cord-259603-bh198xgl	876	6	independent	independent	JJ
cord-259603-bh198xgl	876	7	active	active	JJ
cord-259603-bh198xgl	876	8	sites	site	NNS
cord-259603-bh198xgl	876	9	located	locate	VBN
cord-259603-bh198xgl	876	10	on	on	IN
cord-259603-bh198xgl	876	11	the	the	DT
cord-259603-bh198xgl	876	12	surface	surface	NN
cord-259603-bh198xgl	876	13	of	of	IN
cord-259603-bh198xgl	876	14	the	the	DT
cord-259603-bh198xgl	876	15	molecule	molecule	NN
cord-259603-bh198xgl	876	16	.	.	.
cord-259603-bh198xgl	877	1	Interactions	interaction	NNS
cord-259603-bh198xgl	877	2	between	between	IN
cord-259603-bh198xgl	877	3	individual	individual	JJ
cord-259603-bh198xgl	877	4	protomers	protomer	NNS
cord-259603-bh198xgl	877	5	are	be	VBP
cord-259603-bh198xgl	877	6	predominantly	predominantly	RB
cord-259603-bh198xgl	877	7	mediated	mediate	VBN
cord-259603-bh198xgl	877	8	by	by	IN
cord-259603-bh198xgl	877	9	residues	residue	NNS
cord-259603-bh198xgl	877	10	located	locate	VBN
cord-259603-bh198xgl	877	11	in	in	IN
cord-259603-bh198xgl	877	12	the	the	DT
cord-259603-bh198xgl	877	13	N	N	NNP
cord-259603-bh198xgl	877	14	-	-	HYPH
cord-259603-bh198xgl	877	15	terminal	terminal	JJ
cord-259603-bh198xgl	877	16	and	and	CC
cord-259603-bh198xgl	877	17	middle	middle	JJ
cord-259603-bh198xgl	877	18	domains	domain	NNS
cord-259603-bh198xgl	877	19	.	.	.
cord-259603-bh198xgl	878	1	Database	database	NN
cord-259603-bh198xgl	878	2	searches	search	NNS
cord-259603-bh198xgl	878	3	failed	fail	VBD
cord-259603-bh198xgl	878	4	to	to	TO
cord-259603-bh198xgl	878	5	identify	identify	VB
cord-259603-bh198xgl	878	6	closely	closely	RB
cord-259603-bh198xgl	878	7	related	related	JJ
cord-259603-bh198xgl	878	8	structural	structural	JJ
cord-259603-bh198xgl	878	9	homologs	homolog	NNS
cord-259603-bh198xgl	878	10	,	,	,
cord-259603-bh198xgl	878	11	suggesting	suggest	VBG
cord-259603-bh198xgl	878	12	that	that	IN
cord-259603-bh198xgl	878	13	endoUs	endoUs	NNP
cord-259603-bh198xgl	878	14	diverged	diverge	VBD
cord-259603-bh198xgl	878	15	profoundly	profoundly	RB
cord-259603-bh198xgl	878	16	from	from	IN
cord-259603-bh198xgl	878	17	other	other	JJ
cord-259603-bh198xgl	878	18	ribonucleases	ribonuclease	NNS
cord-259603-bh198xgl	878	19	(	(	-LRB-
cord-259603-bh198xgl	878	20	Renzi	Renzi	NNP
cord-259603-bh198xgl	878	21	et	et	NNP
cord-259603-bh198xgl	878	22	al	al	NNP
cord-259603-bh198xgl	878	23	.	.	NNP
cord-259603-bh198xgl	878	24	,	,	,
cord-259603-bh198xgl	878	25	2006	2006	CD
cord-259603-bh198xgl	878	26	;	;	:
cord-259603-bh198xgl	878	27	Ricagno	Ricagno	NNP
cord-259603-bh198xgl	878	28	et	et	FW
cord-259603-bh198xgl	878	29	al	al	NNP
cord-259603-bh198xgl	878	30	.	.	NNP
cord-259603-bh198xgl	878	31	,	,	,
cord-259603-bh198xgl	878	32	2006	2006	CD
cord-259603-bh198xgl	878	33	)	)	-RRB-
cord-259603-bh198xgl	878	34	.	.	.
cord-259603-bh198xgl	879	1	Nevertheless	nevertheless	RB
cord-259603-bh198xgl	879	2	,	,	,
cord-259603-bh198xgl	879	3	the	the	DT
cord-259603-bh198xgl	879	4	presumed	presume	VBN
cord-259603-bh198xgl	879	5	endoU	endoU	NNP
cord-259603-bh198xgl	879	6	catalytic	catalytic	JJ
cord-259603-bh198xgl	879	7	residues	residue	NNS
cord-259603-bh198xgl	879	8	(	(	-LRB-
cord-259603-bh198xgl	879	9	His	-PRON-	PRP$
cord-259603-bh198xgl	879	10	/	/	SYM
cord-259603-bh198xgl	879	11	His/	His/	NNP
cord-259603-bh198xgl	879	12	Lys	Lys	NNP
cord-259603-bh198xgl	879	13	,	,	,
cord-259603-bh198xgl	879	14	Fig	Fig	NNP
cord-259603-bh198xgl	879	15	.	.	NNP
cord-259603-bh198xgl	879	16	8	8	CD
cord-259603-bh198xgl	879	17	)	)	-RRB-
cord-259603-bh198xgl	879	18	could	could	MD
cord-259603-bh198xgl	879	19	be	be	VB
cord-259603-bh198xgl	879	20	superimposed	superimpose	VBN
cord-259603-bh198xgl	879	21	with	with	IN
cord-259603-bh198xgl	879	22	the	the	DT
cord-259603-bh198xgl	879	23	catalytic	catalytic	JJ
cord-259603-bh198xgl	879	24	His	His	NNP
cord-259603-bh198xgl	879	25	/	/	SYM
cord-259603-bh198xgl	879	26	His	His	NNP
cord-259603-bh198xgl	879	27	/	/	SYM
cord-259603-bh198xgl	879	28	Lys	Lys	NNP
cord-259603-bh198xgl	879	29	residues	residue	NNS
cord-259603-bh198xgl	879	30	of	of	IN
cord-259603-bh198xgl	879	31	bovine	bovine	JJ
cord-259603-bh198xgl	879	32	RNase	RNase	NNP
cord-259603-bh198xgl	879	33	A	A	NNP
cord-259603-bh198xgl	879	34	,	,	,
cord-259603-bh198xgl	879	35	the	the	DT
cord-259603-bh198xgl	879	36	prototype	prototype	NN
cord-259603-bh198xgl	879	37	of	of	IN
cord-259603-bh198xgl	879	38	a	a	DT
cord-259603-bh198xgl	879	39	large	large	JJ
cord-259603-bh198xgl	879	40	superfamily	superfamily	NN
cord-259603-bh198xgl	879	41	of	of	IN
cord-259603-bh198xgl	879	42	pyrimidinespecific	pyrimidinespecific	NNP
cord-259603-bh198xgl	879	43	ribonucleases	ribonucleases	NNPS
cord-259603-bh198xgl	880	1	(	(	-LRB-
cord-259603-bh198xgl	880	2	Ricagno	Ricagno	NNP
cord-259603-bh198xgl	880	3	et	et	FW
cord-259603-bh198xgl	880	4	al	al	NNP
cord-259603-bh198xgl	880	5	.	.	NNP
cord-259603-bh198xgl	880	6	,	,	,
cord-259603-bh198xgl	880	7	2006	2006	CD
cord-259603-bh198xgl	880	8	;	;	.
cord-259603-bh198xgl	881	1	Ulferts	Ulferts	NNP
cord-259603-bh198xgl	881	2	and	and	CC
cord-259603-bh198xgl	881	3	Ziebuhr	Ziebuhr	NNP
cord-259603-bh198xgl	881	4	,	,	,
cord-259603-bh198xgl	881	5	2011	2011	CD
cord-259603-bh198xgl	881	6	)	)	-RRB-
cord-259603-bh198xgl	881	7	.	.	.
cord-259603-bh198xgl	882	1	The	the	DT
cord-259603-bh198xgl	882	2	superposition	superposition	NN
cord-259603-bh198xgl	882	3	also	also	RB
cord-259603-bh198xgl	882	4	includes	include	VBZ
cord-259603-bh198xgl	882	5	a	a	DT
cord-259603-bh198xgl	882	6	number	number	NN
cord-259603-bh198xgl	882	7	of	of	IN
cord-259603-bh198xgl	882	8	conserved	conserve	VBN
cord-259603-bh198xgl	882	9	substrate	substrate	NN
cord-259603-bh198xgl	882	10	-	-	HYPH
cord-259603-bh198xgl	882	11	binding	bind	VBG
cord-259603-bh198xgl	882	12	residues	residue	NNS
cord-259603-bh198xgl	882	13	.	.	.
cord-259603-bh198xgl	883	1	A	a	DT
cord-259603-bh198xgl	883	2	comparison	comparison	NN
cord-259603-bh198xgl	883	3	of	of	IN
cord-259603-bh198xgl	883	4	viral	viral	JJ
cord-259603-bh198xgl	883	5	and	and	CC
cord-259603-bh198xgl	883	6	cellular	cellular	JJ
cord-259603-bh198xgl	883	7	endoU	endou	JJ
cord-259603-bh198xgl	883	8	structures	structure	NNS
cord-259603-bh198xgl	883	9	with	with	IN
cord-259603-bh198xgl	883	10	that	that	DT
cord-259603-bh198xgl	883	11	of	of	IN
cord-259603-bh198xgl	883	12	RNase	RNase	NNP
cord-259603-bh198xgl	883	13	A	A	NNP
cord-259603-bh198xgl	883	14	and	and	CC
cord-259603-bh198xgl	883	15	related	relate	VBN
cord-259603-bh198xgl	883	16	nucleases	nuclease	NNS
cord-259603-bh198xgl	883	17	using	use	VBG
cord-259603-bh198xgl	883	18	the	the	DT
cord-259603-bh198xgl	883	19	PDBefold	pdbefold	NN
cord-259603-bh198xgl	883	20	server	server	NN
cord-259603-bh198xgl	883	21	revealed	reveal	VBD
cord-259603-bh198xgl	883	22	similarities	similarity	NNS
cord-259603-bh198xgl	883	23	between	between	IN
cord-259603-bh198xgl	883	24	the	the	DT
cord-259603-bh198xgl	883	25	structural	structural	JJ
cord-259603-bh198xgl	883	26	cores	core	NNS
cord-259603-bh198xgl	883	27	of	of	IN
cord-259603-bh198xgl	883	28	these	these	DT
cord-259603-bh198xgl	883	29	enzymes	enzyme	NNS
cord-259603-bh198xgl	883	30	that	that	WDT
cord-259603-bh198xgl	883	31	may	may	MD
cord-259603-bh198xgl	883	32	be	be	VB
cord-259603-bh198xgl	883	33	described	describe	VBN
cord-259603-bh198xgl	883	34	as	as	IN
cord-259603-bh198xgl	883	35	"	"	``
cord-259603-bh198xgl	883	36	interrelated	interrelate	VBN
cord-259603-bh198xgl	883	37	by	by	IN
cord-259603-bh198xgl	883	38	topological	topological	JJ
cord-259603-bh198xgl	883	39	permutation	permutation	NN
cord-259603-bh198xgl	883	40	,	,	,
cord-259603-bh198xgl	883	41	"	"	''
cord-259603-bh198xgl	883	42	providing	provide	VBG
cord-259603-bh198xgl	883	43	initial	initial	JJ
cord-259603-bh198xgl	883	44	evidence	evidence	NN
cord-259603-bh198xgl	883	45	for	for	IN
cord-259603-bh198xgl	883	46	a	a	DT
cord-259603-bh198xgl	883	47	common	common	JJ
cord-259603-bh198xgl	883	48	ancestry	ancestry	NN
cord-259603-bh198xgl	883	49	of	of	IN
cord-259603-bh198xgl	883	50	the	the	DT
cord-259603-bh198xgl	883	51	two	two	CD
cord-259603-bh198xgl	883	52	endonuclease	endonuclease	NN
cord-259603-bh198xgl	883	53	families	family	NNS
cord-259603-bh198xgl	883	54	(	(	-LRB-
cord-259603-bh198xgl	883	55	Ulferts	Ulferts	NNP
cord-259603-bh198xgl	883	56	and	and	CC
cord-259603-bh198xgl	883	57	Ziebuhr	Ziebuhr	NNP
cord-259603-bh198xgl	883	58	,	,	,
cord-259603-bh198xgl	883	59	2011	2011	CD
cord-259603-bh198xgl	883	60	)	)	-RRB-
cord-259603-bh198xgl	883	61	.	.	.
cord-259603-bh198xgl	884	1	Further	further	JJ
cord-259603-bh198xgl	884	2	studies	study	NNS
cord-259603-bh198xgl	884	3	are	be	VBP
cord-259603-bh198xgl	884	4	required	require	VBN
cord-259603-bh198xgl	884	5	to	to	TO
cord-259603-bh198xgl	884	6	substantiate	substantiate	VB
cord-259603-bh198xgl	884	7	this	this	DT
cord-259603-bh198xgl	884	8	hypothesis	hypothesis	NN
cord-259603-bh198xgl	884	9	(	(	-LRB-
cord-259603-bh198xgl	884	10	see	see	VB
cord-259603-bh198xgl	884	11	later	later	RB
cord-259603-bh198xgl	884	12	)	)	-RRB-
cord-259603-bh198xgl	884	13	.	.	.
cord-259603-bh198xgl	885	1	The	the	DT
cord-259603-bh198xgl	885	2	hexameric	hexameric	JJ
cord-259603-bh198xgl	885	3	form	form	NN
cord-259603-bh198xgl	885	4	is	be	VBZ
cord-259603-bh198xgl	885	5	thought	think	VBN
cord-259603-bh198xgl	885	6	to	to	TO
cord-259603-bh198xgl	885	7	be	be	VB
cord-259603-bh198xgl	885	8	the	the	DT
cord-259603-bh198xgl	885	9	fully	fully	RB
cord-259603-bh198xgl	885	10	active	active	JJ
cord-259603-bh198xgl	885	11	form	form	NN
cord-259603-bh198xgl	885	12	of	of	IN
cord-259603-bh198xgl	885	13	CoV	cov	NN
cord-259603-bh198xgl	885	14	nsp15	nsp15	CD
cord-259603-bh198xgl	885	15	.	.	.
cord-259603-bh198xgl	886	1	This	this	DT
cord-259603-bh198xgl	886	2	is	be	VBZ
cord-259603-bh198xgl	886	3	supported	support	VBN
cord-259603-bh198xgl	886	4	by	by	IN
cord-259603-bh198xgl	886	5	the	the	DT
cord-259603-bh198xgl	886	6	exponential	exponential	JJ
cord-259603-bh198xgl	886	7	increase	increase	NN
cord-259603-bh198xgl	886	8	of	of	IN
cord-259603-bh198xgl	886	9	activity	activity	NN
cord-259603-bh198xgl	886	10	with	with	IN
cord-259603-bh198xgl	886	11	increased	increase	VBN
cord-259603-bh198xgl	886	12	protein	protein	NN
cord-259603-bh198xgl	886	13	concentrations	concentration	NNS
cord-259603-bh198xgl	886	14	,	,	,
cord-259603-bh198xgl	886	15	the	the	DT
cord-259603-bh198xgl	886	16	reduced	reduce	VBN
cord-259603-bh198xgl	886	17	activities	activity	NNS
cord-259603-bh198xgl	886	18	determined	determine	VBN
cord-259603-bh198xgl	886	19	for	for	IN
cord-259603-bh198xgl	886	20	protein	protein	NN
cord-259603-bh198xgl	886	21	variants	variant	NNS
cord-259603-bh198xgl	886	22	that	that	WDT
cord-259603-bh198xgl	886	23	do	do	VBP
cord-259603-bh198xgl	886	24	not	not	RB
cord-259603-bh198xgl	886	25	multimerize	multimerize	VB
cord-259603-bh198xgl	886	26	and	and	CC
cord-259603-bh198xgl	886	27	the	the	DT
cord-259603-bh198xgl	886	28	increased	increase	VBN
cord-259603-bh198xgl	886	29	RNA	RNA	NNP
cord-259603-bh198xgl	886	30	-	-	HYPH
cord-259603-bh198xgl	886	31	binding	bind	VBG
cord-259603-bh198xgl	886	32	activities	activity	NNS
cord-259603-bh198xgl	886	33	observed	observe	VBN
cord-259603-bh198xgl	886	34	for	for	IN
cord-259603-bh198xgl	886	35	hexameric	hexameric	JJ
cord-259603-bh198xgl	886	36	forms	form	NNS
cord-259603-bh198xgl	886	37	of	of	IN
cord-259603-bh198xgl	886	38	endoU	endou	NN
cord-259603-bh198xgl	887	1	(	(	-LRB-
cord-259603-bh198xgl	887	2	Bhardwaj	Bhardwaj	NNP
cord-259603-bh198xgl	887	3	et	et	NNP
cord-259603-bh198xgl	887	4	al	al	NNP
cord-259603-bh198xgl	887	5	.	.	NNP
cord-259603-bh198xgl	887	6	,	,	,
cord-259603-bh198xgl	887	7	2006	2006	CD
cord-259603-bh198xgl	887	8	;	;	.
cord-259603-bh198xgl	888	1	Guarino	Guarino	NNP
cord-259603-bh198xgl	888	2	et	et	NNP
cord-259603-bh198xgl	888	3	al	al	NNP
cord-259603-bh198xgl	888	4	.	.	NNP
cord-259603-bh198xgl	888	5	,	,	,
cord-259603-bh198xgl	888	6	2005	2005	CD
cord-259603-bh198xgl	889	1	;	;	:
cord-259603-bh198xgl	889	2	Xu	Xu	NNP
cord-259603-bh198xgl	889	3	et	et	NNP
cord-259603-bh198xgl	889	4	al	al	NNP
cord-259603-bh198xgl	889	5	.	.	NNP
cord-259603-bh198xgl	889	6	,	,	,
cord-259603-bh198xgl	889	7	2006	2006	CD
cord-259603-bh198xgl	889	8	)	)	-RRB-
cord-259603-bh198xgl	889	9	.	.	.
cord-259603-bh198xgl	890	1	Consistent	consistent	JJ
cord-259603-bh198xgl	890	2	with	with	IN
cord-259603-bh198xgl	890	3	this	this	DT
cord-259603-bh198xgl	890	4	,	,	,
cord-259603-bh198xgl	890	5	hexamerization	hexamerization	NNP
cord-259603-bh198xgl	890	6	has	have	VBZ
cord-259603-bh198xgl	890	7	been	be	VBN
cord-259603-bh198xgl	890	8	confirmed	confirm	VBN
cord-259603-bh198xgl	890	9	for	for	IN
cord-259603-bh198xgl	890	10	different	different	JJ
cord-259603-bh198xgl	890	11	CoV	cov	NN
cord-259603-bh198xgl	890	12	endoU	endou	NN
cord-259603-bh198xgl	890	13	homologs	homolog	NNS
cord-259603-bh198xgl	890	14	and	and	CC
cord-259603-bh198xgl	890	15	residues	residue	NNS
cord-259603-bh198xgl	890	16	confirmed	confirm	VBD
cord-259603-bh198xgl	890	17	to	to	TO
cord-259603-bh198xgl	890	18	be	be	VB
cord-259603-bh198xgl	890	19	involved	involve	VBN
cord-259603-bh198xgl	890	20	in	in	IN
cord-259603-bh198xgl	890	21	intersubunit	intersubunit	JJ
cord-259603-bh198xgl	890	22	interactions	interaction	NNS
cord-259603-bh198xgl	890	23	are	be	VBP
cord-259603-bh198xgl	890	24	highly	highly	RB
cord-259603-bh198xgl	890	25	conserved	conserve	VBN
cord-259603-bh198xgl	890	26	among	among	IN
cord-259603-bh198xgl	890	27	CoVs	CoVs	NNP
cord-259603-bh198xgl	890	28	.	.	.
cord-259603-bh198xgl	891	1	In	in	IN
cord-259603-bh198xgl	891	2	the	the	DT
cord-259603-bh198xgl	891	3	structure	structure	NN
cord-259603-bh198xgl	891	4	of	of	IN
cord-259603-bh198xgl	891	5	a	a	DT
cord-259603-bh198xgl	891	6	truncated	truncated	JJ
cord-259603-bh198xgl	891	7	,	,	,
cord-259603-bh198xgl	891	8	monomeric	monomeric	JJ
cord-259603-bh198xgl	891	9	form	form	NN
cord-259603-bh198xgl	891	10	of	of	IN
cord-259603-bh198xgl	891	11	SARS	SARS	NNP
cord-259603-bh198xgl	891	12	-	-	HYPH
cord-259603-bh198xgl	891	13	CoV	CoV	NNP
cord-259603-bh198xgl	891	14	nsp15	nsp15	NNP
cord-259603-bh198xgl	891	15	that	that	WDT
cord-259603-bh198xgl	891	16	lacks	lack	VBZ
cord-259603-bh198xgl	891	17	28	28	CD
cord-259603-bh198xgl	891	18	N	n	CD
cord-259603-bh198xgl	891	19	-	-	HYPH
cord-259603-bh198xgl	891	20	terminal	terminal	NN
cord-259603-bh198xgl	891	21	and	and	CC
cord-259603-bh198xgl	891	22	11	11	CD
cord-259603-bh198xgl	891	23	C	c	NN
cord-259603-bh198xgl	891	24	-	-	HYPH
cord-259603-bh198xgl	891	25	terminal	terminal	NN
cord-259603-bh198xgl	891	26	residues	residue	NNS
cord-259603-bh198xgl	891	27	,	,	,
cord-259603-bh198xgl	891	28	two	two	CD
cord-259603-bh198xgl	891	29	loops	loop	NNS
cord-259603-bh198xgl	891	30	of	of	IN
cord-259603-bh198xgl	891	31	the	the	DT
cord-259603-bh198xgl	891	32	catalytic	catalytic	JJ
cord-259603-bh198xgl	891	33	domain	domain	NN
cord-259603-bh198xgl	891	34	were	be	VBD
cord-259603-bh198xgl	891	35	found	find	VBN
cord-259603-bh198xgl	891	36	to	to	TO
cord-259603-bh198xgl	891	37	be	be	VB
cord-259603-bh198xgl	891	38	displaced	displace	VBN
cord-259603-bh198xgl	891	39	compared	compare	VBN
cord-259603-bh198xgl	891	40	to	to	IN
cord-259603-bh198xgl	891	41	their	-PRON-	PRP$
cord-259603-bh198xgl	891	42	location	location	NN
cord-259603-bh198xgl	891	43	in	in	IN
cord-259603-bh198xgl	891	44	the	the	DT
cord-259603-bh198xgl	891	45	hexamer	hexamer	NN
cord-259603-bh198xgl	891	46	,	,	,
cord-259603-bh198xgl	891	47	resulting	result	VBG
cord-259603-bh198xgl	891	48	in	in	IN
cord-259603-bh198xgl	891	49	the	the	DT
cord-259603-bh198xgl	891	50	destruction	destruction	NN
cord-259603-bh198xgl	891	51	of	of	IN
cord-259603-bh198xgl	891	52	the	the	DT
cord-259603-bh198xgl	891	53	active	active	JJ
cord-259603-bh198xgl	891	54	site	site	NN
cord-259603-bh198xgl	891	55	(	(	-LRB-
cord-259603-bh198xgl	891	56	Joseph	Joseph	NNP
cord-259603-bh198xgl	891	57	et	et	NNP
cord-259603-bh198xgl	891	58	al	al	NNP
cord-259603-bh198xgl	891	59	.	.	NNP
cord-259603-bh198xgl	891	60	,	,	,
cord-259603-bh198xgl	891	61	2007	2007	CD
cord-259603-bh198xgl	891	62	)	)	-RRB-
cord-259603-bh198xgl	891	63	.	.	.
cord-259603-bh198xgl	892	1	In	in	IN
cord-259603-bh198xgl	892	2	hexameric	hexameric	JJ
cord-259603-bh198xgl	892	3	structures	structure	NNS
cord-259603-bh198xgl	892	4	,	,	,
cord-259603-bh198xgl	892	5	the	the	DT
cord-259603-bh198xgl	892	6	two	two	CD
cord-259603-bh198xgl	892	7	loops	loop	NNS
cord-259603-bh198xgl	892	8	pack	pack	VBP
cord-259603-bh198xgl	892	9	against	against	IN
cord-259603-bh198xgl	892	10	each	each	DT
cord-259603-bh198xgl	892	11	other	other	JJ
cord-259603-bh198xgl	892	12	and	and	CC
cord-259603-bh198xgl	892	13	are	be	VBP
cord-259603-bh198xgl	892	14	stabilized	stabilize	VBN
cord-259603-bh198xgl	892	15	by	by	IN
cord-259603-bh198xgl	892	16	intermonomer	intermonomer	JJ
cord-259603-bh198xgl	892	17	interactions	interaction	NNS
cord-259603-bh198xgl	892	18	,	,	,
cord-259603-bh198xgl	892	19	suggesting	suggest	VBG
cord-259603-bh198xgl	892	20	that	that	IN
cord-259603-bh198xgl	892	21	hexamerization	hexamerization	NN
cord-259603-bh198xgl	892	22	may	may	MD
cord-259603-bh198xgl	892	23	induce	induce	VB
cord-259603-bh198xgl	892	24	an	an	DT
cord-259603-bh198xgl	892	25	allosteric	allosteric	JJ
cord-259603-bh198xgl	892	26	switch	switch	NN
cord-259603-bh198xgl	892	27	.	.	.
cord-259603-bh198xgl	893	1	Furthermore	furthermore	RB
cord-259603-bh198xgl	893	2	,	,	,
cord-259603-bh198xgl	893	3	cross	cross	NN
cord-259603-bh198xgl	893	4	-	-	JJ
cord-259603-bh198xgl	893	5	linking	linking	JJ
cord-259603-bh198xgl	893	6	and	and	CC
cord-259603-bh198xgl	893	7	cryoelectron	cryoelectron	NNP
cord-259603-bh198xgl	893	8	microscopy	microscopy	NNP
cord-259603-bh198xgl	893	9	studies	study	NNS
cord-259603-bh198xgl	893	10	support	support	VBP
cord-259603-bh198xgl	893	11	a	a	DT
cord-259603-bh198xgl	893	12	specific	specific	JJ
cord-259603-bh198xgl	893	13	role	role	NN
cord-259603-bh198xgl	893	14	of	of	IN
cord-259603-bh198xgl	893	15	hexamerization	hexamerization	NN
cord-259603-bh198xgl	893	16	in	in	IN
cord-259603-bh198xgl	893	17	RNA	RNA	NNP
cord-259603-bh198xgl	893	18	binding	bind	VBG
cord-259603-bh198xgl	893	19	(	(	-LRB-
cord-259603-bh198xgl	893	20	Bhardwaj	Bhardwaj	NNP
cord-259603-bh198xgl	893	21	et	et	NNP
cord-259603-bh198xgl	893	22	al	al	NNP
cord-259603-bh198xgl	893	23	.	.	NNP
cord-259603-bh198xgl	893	24	,	,	,
cord-259603-bh198xgl	893	25	2006	2006	CD
cord-259603-bh198xgl	894	1	(	(	-LRB-
cord-259603-bh198xgl	894	2	Bhardwaj	Bhardwaj	NNP
cord-259603-bh198xgl	894	3	et	et	NNP
cord-259603-bh198xgl	894	4	al	al	NNP
cord-259603-bh198xgl	894	5	.	.	NNP
cord-259603-bh198xgl	894	6	,	,	,
cord-259603-bh198xgl	894	7	,	,	,
cord-259603-bh198xgl	894	8	2008	2008	CD
cord-259603-bh198xgl	894	9	.	.	.
cord-259603-bh198xgl	895	1	In	in	IN
cord-259603-bh198xgl	895	2	the	the	DT
cord-259603-bh198xgl	895	3	structure	structure	NN
cord-259603-bh198xgl	895	4	model	model	NN
cord-259603-bh198xgl	895	5	,	,	,
cord-259603-bh198xgl	895	6	the	the	DT
cord-259603-bh198xgl	895	7	proposed	propose	VBN
cord-259603-bh198xgl	895	8	active	active	JJ
cord-259603-bh198xgl	895	9	-	-	HYPH
cord-259603-bh198xgl	895	10	site	site	NN
cord-259603-bh198xgl	895	11	His	-PRON-	PRP$
cord-259603-bh198xgl	895	12	and	and	CC
cord-259603-bh198xgl	895	13	Lys	Lys	NNP
cord-259603-bh198xgl	895	14	residues	residue	NNS
cord-259603-bh198xgl	895	15	(	(	-LRB-
cord-259603-bh198xgl	895	16	Fig	Fig	NNP
cord-259603-bh198xgl	895	17	.	.	.
cord-259603-bh198xgl	895	18	8)	8)	NNP
cord-259603-bh198xgl	895	19	identified	identify	VBN
cord-259603-bh198xgl	895	20	by	by	IN
cord-259603-bh198xgl	895	21	comparative	comparative	JJ
cord-259603-bh198xgl	895	22	sequence	sequence	NN
cord-259603-bh198xgl	895	23	analysis	analysis	NN
cord-259603-bh198xgl	895	24	and	and	CC
cord-259603-bh198xgl	895	25	site	site	NN
cord-259603-bh198xgl	895	26	-	-	HYPH
cord-259603-bh198xgl	895	27	directed	direct	VBN
cord-259603-bh198xgl	895	28	mutagenesis	mutagenesis	NN
cord-259603-bh198xgl	896	1	(	(	-LRB-
cord-259603-bh198xgl	896	2	Bhardwaj	Bhardwaj	NNP
cord-259603-bh198xgl	896	3	et	et	NNP
cord-259603-bh198xgl	896	4	al	al	NNP
cord-259603-bh198xgl	896	5	.	.	NNP
cord-259603-bh198xgl	896	6	,	,	,
cord-259603-bh198xgl	896	7	2004	2004	CD
cord-259603-bh198xgl	896	8	;	;	:
cord-259603-bh198xgl	896	9	Gioia	Gioia	NNP
cord-259603-bh198xgl	896	10	et	et	FW
cord-259603-bh198xgl	896	11	al	al	NNP
cord-259603-bh198xgl	896	12	.	.	.
cord-259603-bh198xgl	897	1	,	,	,
cord-259603-bh198xgl	897	2	2005	2005	CD
cord-259603-bh198xgl	897	3	;	;	:
cord-259603-bh198xgl	897	4	Guarino	Guarino	NNP
cord-259603-bh198xgl	897	5	et	et	NNP
cord-259603-bh198xgl	897	6	al	al	NNP
cord-259603-bh198xgl	897	7	.	.	NNP
cord-259603-bh198xgl	897	8	,	,	,
cord-259603-bh198xgl	897	9	2005	2005	CD
cord-259603-bh198xgl	898	1	;	;	:
cord-259603-bh198xgl	898	2	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	898	3	et	et	NNP
cord-259603-bh198xgl	898	4	al	al	NNP
cord-259603-bh198xgl	898	5	.	.	.
cord-259603-bh198xgl	899	1	,	,	,
cord-259603-bh198xgl	899	2	2004a	2004a	CD
cord-259603-bh198xgl	899	3	;	;	:
cord-259603-bh198xgl	899	4	Kang	Kang	NNP
cord-259603-bh198xgl	899	5	et	et	NNP
cord-259603-bh198xgl	899	6	al	al	NNP
cord-259603-bh198xgl	899	7	.	.	NNP
cord-259603-bh198xgl	899	8	,	,	,
cord-259603-bh198xgl	899	9	2007	2007	CD
cord-259603-bh198xgl	899	10	;	;	:
cord-259603-bh198xgl	899	11	Snijder	Snijder	NNP
cord-259603-bh198xgl	899	12	et	et	NNP
cord-259603-bh198xgl	899	13	al	al	NNP
cord-259603-bh198xgl	899	14	.	.	NNP
cord-259603-bh198xgl	899	15	,	,	,
cord-259603-bh198xgl	899	16	2003	2003	CD
cord-259603-bh198xgl	899	17	)	)	-RRB-
cord-259603-bh198xgl	899	18	were	be	VBD
cord-259603-bh198xgl	899	19	found	find	VBN
cord-259603-bh198xgl	899	20	to	to	TO
cord-259603-bh198xgl	899	21	be	be	VB
cord-259603-bh198xgl	899	22	embedded	embed	VBN
cord-259603-bh198xgl	899	23	in	in	IN
cord-259603-bh198xgl	899	24	a	a	DT
cord-259603-bh198xgl	899	25	positively	positively	RB
cord-259603-bh198xgl	899	26	charged	charge	VBN
cord-259603-bh198xgl	899	27	groove	groove	NN
cord-259603-bh198xgl	899	28	of	of	IN
cord-259603-bh198xgl	899	29	the	the	DT
cord-259603-bh198xgl	899	30	catalytic	catalytic	JJ
cord-259603-bh198xgl	899	31	domain	domain	NN
cord-259603-bh198xgl	899	32	.	.	.
cord-259603-bh198xgl	900	1	Other	other	JJ
cord-259603-bh198xgl	900	2	residues	residue	NNS
cord-259603-bh198xgl	900	3	identified	identify	VBN
cord-259603-bh198xgl	900	4	in	in	IN
cord-259603-bh198xgl	900	5	the	the	DT
cord-259603-bh198xgl	900	6	active	active	JJ
cord-259603-bh198xgl	900	7	site	site	NN
cord-259603-bh198xgl	900	8	and	and	CC
cord-259603-bh198xgl	900	9	proposed	propose	VBD
cord-259603-bh198xgl	900	10	to	to	TO
cord-259603-bh198xgl	900	11	be	be	VB
cord-259603-bh198xgl	900	12	involved	involve	VBN
cord-259603-bh198xgl	900	13	in	in	IN
cord-259603-bh198xgl	900	14	binding	bind	VBG
cord-259603-bh198xgl	900	15	to	to	IN
cord-259603-bh198xgl	900	16	the	the	DT
cord-259603-bh198xgl	900	17	substrate	substrate	NN
cord-259603-bh198xgl	900	18	phosphate	phosphate	NN
cord-259603-bh198xgl	900	19	include	include	VBP
cord-259603-bh198xgl	900	20	the	the	DT
cord-259603-bh198xgl	900	21	side	side	NN
cord-259603-bh198xgl	900	22	chain	chain	NN
cord-259603-bh198xgl	900	23	of	of	IN
cord-259603-bh198xgl	900	24	a	a	DT
cord-259603-bh198xgl	900	25	conserved	conserve	VBN
cord-259603-bh198xgl	900	26	Thr	Thr	NNP
cord-259603-bh198xgl	900	27	(	(	-LRB-
cord-259603-bh198xgl	900	28	Fig	Fig	NNP
cord-259603-bh198xgl	900	29	.	.	.
cord-259603-bh198xgl	900	30	8	8	CD
cord-259603-bh198xgl	900	31	)	)	-RRB-
cord-259603-bh198xgl	900	32	and	and	CC
cord-259603-bh198xgl	900	33	the	the	DT
cord-259603-bh198xgl	900	34	main	main	JJ
cord-259603-bh198xgl	900	35	chain	chain	NN
cord-259603-bh198xgl	900	36	amide	amide	NN
cord-259603-bh198xgl	900	37	of	of	IN
cord-259603-bh198xgl	900	38	a	a	DT
cord-259603-bh198xgl	900	39	conserved	conserve	VBN
cord-259603-bh198xgl	900	40	Gly	Gly	NNP
cord-259603-bh198xgl	900	41	(	(	-LRB-
cord-259603-bh198xgl	900	42	Fig	Fig	NNP
cord-259603-bh198xgl	900	43	.	.	.
cord-259603-bh198xgl	900	44	1	1	CD
cord-259603-bh198xgl	900	45	)	)	-RRB-
cord-259603-bh198xgl	901	1	(	(	-LRB-
cord-259603-bh198xgl	901	2	Bhardwaj	Bhardwaj	NNP
cord-259603-bh198xgl	901	3	et	et	NNP
cord-259603-bh198xgl	901	4	al	al	NNP
cord-259603-bh198xgl	901	5	.	.	NNP
cord-259603-bh198xgl	901	6	,	,	,
cord-259603-bh198xgl	901	7	2008	2008	CD
cord-259603-bh198xgl	902	1	;	;	:
cord-259603-bh198xgl	902	2	Ricagno	Ricagno	NNP
cord-259603-bh198xgl	902	3	et	et	FW
cord-259603-bh198xgl	902	4	al	al	NNP
cord-259603-bh198xgl	902	5	.	.	NNP
cord-259603-bh198xgl	902	6	,	,	,
cord-259603-bh198xgl	902	7	2006	2006	CD
cord-259603-bh198xgl	903	1	;	;	:
cord-259603-bh198xgl	903	2	Xu	Xu	NNP
cord-259603-bh198xgl	903	3	et	et	NNP
cord-259603-bh198xgl	903	4	al	al	NNP
cord-259603-bh198xgl	903	5	.	.	NNP
cord-259603-bh198xgl	903	6	,	,	,
cord-259603-bh198xgl	903	7	2006	2006	CD
cord-259603-bh198xgl	903	8	)	)	-RRB-
cord-259603-bh198xgl	903	9	.	.	.
cord-259603-bh198xgl	904	1	The	the	DT
cord-259603-bh198xgl	904	2	proposed	propose	VBN
cord-259603-bh198xgl	904	3	functional	functional	JJ
cord-259603-bh198xgl	904	4	role	role	NN
cord-259603-bh198xgl	904	5	of	of	IN
cord-259603-bh198xgl	904	6	the	the	DT
cord-259603-bh198xgl	904	7	latter	latter	JJ
cord-259603-bh198xgl	904	8	residues	residue	NNS
cord-259603-bh198xgl	904	9	has	have	VBZ
cord-259603-bh198xgl	904	10	also	also	RB
cord-259603-bh198xgl	904	11	been	be	VBN
cord-259603-bh198xgl	904	12	corroborated	corroborate	VBN
cord-259603-bh198xgl	904	13	by	by	IN
cord-259603-bh198xgl	904	14	mutagenesis	mutagenesis	NN
cord-259603-bh198xgl	904	15	data	datum	NNS
cord-259603-bh198xgl	904	16	for	for	IN
cord-259603-bh198xgl	904	17	several	several	JJ
cord-259603-bh198xgl	904	18	endoU	endoU	NNP
cord-259603-bh198xgl	904	19	homologs	homolog	NNS
cord-259603-bh198xgl	904	20	(	(	-LRB-
cord-259603-bh198xgl	904	21	Kang	Kang	NNP
cord-259603-bh198xgl	904	22	et	et	NNP
cord-259603-bh198xgl	904	23	al	al	NNP
cord-259603-bh198xgl	904	24	.	.	NNP
cord-259603-bh198xgl	904	25	,	,	,
cord-259603-bh198xgl	904	26	2007	2007	CD
cord-259603-bh198xgl	904	27	;	;	:
cord-259603-bh198xgl	904	28	Renzi	Renzi	NNP
cord-259603-bh198xgl	904	29	et	et	NNP
cord-259603-bh198xgl	904	30	al	al	NNP
cord-259603-bh198xgl	904	31	.	.	NNP
cord-259603-bh198xgl	904	32	,	,	,
cord-259603-bh198xgl	904	33	2006	2006	CD
cord-259603-bh198xgl	904	34	;	;	:
cord-259603-bh198xgl	904	35	Ricagno	Ricagno	NNP
cord-259603-bh198xgl	904	36	et	et	FW
cord-259603-bh198xgl	904	37	al	al	NNP
cord-259603-bh198xgl	904	38	.	.	NNP
cord-259603-bh198xgl	904	39	,	,	,
cord-259603-bh198xgl	904	40	2006	2006	CD
cord-259603-bh198xgl	904	41	)	)	-RRB-
cord-259603-bh198xgl	904	42	.	.	.
cord-259603-bh198xgl	905	1	As	as	IN
cord-259603-bh198xgl	905	2	mentioned	mention	VBN
cord-259603-bh198xgl	905	3	earlier	early	RBR
cord-259603-bh198xgl	905	4	,	,	,
cord-259603-bh198xgl	905	5	endoU	endoU	NNP
cord-259603-bh198xgl	905	6	and	and	CC
cord-259603-bh198xgl	905	7	RNase	RNase	NNP
cord-259603-bh198xgl	905	8	A	a	DT
cord-259603-bh198xgl	905	9	share	share	NN
cord-259603-bh198xgl	905	10	a	a	DT
cord-259603-bh198xgl	905	11	number	number	NN
cord-259603-bh198xgl	905	12	of	of	IN
cord-259603-bh198xgl	905	13	features	feature	NNS
cord-259603-bh198xgl	905	14	in	in	IN
cord-259603-bh198xgl	905	15	their	-PRON-	PRP$
cord-259603-bh198xgl	905	16	active	active	JJ
cord-259603-bh198xgl	905	17	sites	site	NNS
cord-259603-bh198xgl	905	18	.	.	.
cord-259603-bh198xgl	906	1	In	in	IN
cord-259603-bh198xgl	906	2	RNase	RNase	NNP
cord-259603-bh198xgl	906	3	A	A	NNP
cord-259603-bh198xgl	906	4	,	,	,
cord-259603-bh198xgl	906	5	pyrimidine	pyrimidine	NN
cord-259603-bh198xgl	906	6	binding	binding	NN
cord-259603-bh198xgl	906	7	primarily	primarily	RB
cord-259603-bh198xgl	906	8	involves	involve	VBZ
cord-259603-bh198xgl	906	9	Thr-45	Thr-45	NNP
cord-259603-bh198xgl	906	10	and	and	CC
cord-259603-bh198xgl	906	11	Phe-120	Phe-120	NNP
cord-259603-bh198xgl	906	12	.	.	.
cord-259603-bh198xgl	907	1	While	while	IN
cord-259603-bh198xgl	907	2	Thr-45	thr-45	JJ
cord-259603-bh198xgl	907	3	forms	form	VBZ
cord-259603-bh198xgl	907	4	hydrogen	hydrogen	NN
cord-259603-bh198xgl	907	5	bonds	bond	NNS
cord-259603-bh198xgl	907	6	with	with	IN
cord-259603-bh198xgl	907	7	the	the	DT
cord-259603-bh198xgl	907	8	pyrimidine	pyrimidine	NN
cord-259603-bh198xgl	907	9	base	base	NN
cord-259603-bh198xgl	907	10	,	,	,
cord-259603-bh198xgl	907	11	Phe-120	Phe-120	NNP
cord-259603-bh198xgl	907	12	interacts	interact	VBZ
cord-259603-bh198xgl	907	13	with	with	IN
cord-259603-bh198xgl	907	14	the	the	DT
cord-259603-bh198xgl	907	15	base	base	NN
cord-259603-bh198xgl	907	16	through	through	IN
cord-259603-bh198xgl	907	17	stacking	stack	VBG
cord-259603-bh198xgl	907	18	interactions	interaction	NNS
cord-259603-bh198xgl	907	19	(	(	-LRB-
cord-259603-bh198xgl	907	20	Raines	Raines	NNP
cord-259603-bh198xgl	907	21	,	,	,
cord-259603-bh198xgl	907	22	1998	1998	CD
cord-259603-bh198xgl	907	23	)	)	-RRB-
cord-259603-bh198xgl	907	24	.	.	.
cord-259603-bh198xgl	908	1	The	the	DT
cord-259603-bh198xgl	908	2	Ser-293	Ser-293	NNP
cord-259603-bh198xgl	908	3	/	/	SYM
cord-259603-bh198xgl	908	4	Tyr-342	tyr-342	CD
cord-259603-bh198xgl	908	5	residues	residue	NNS
cord-259603-bh198xgl	908	6	of	of	IN
cord-259603-bh198xgl	908	7	SARS	SARS	NNP
cord-259603-bh198xgl	908	8	-	-	HYPH
cord-259603-bh198xgl	908	9	CoV	CoV	NNP
cord-259603-bh198xgl	908	10	nsp15	nsp15	''
cord-259603-bh198xgl	908	11	and	and	CC
cord-259603-bh198xgl	908	12	the	the	DT
cord-259603-bh198xgl	908	13	Thr-45	Thr-45	NNP
cord-259603-bh198xgl	908	14	/	/	SYM
cord-259603-bh198xgl	908	15	Phe-120	Phe-120	NNP
cord-259603-bh198xgl	908	16	residues	residue	NNS
cord-259603-bh198xgl	908	17	of	of	IN
cord-259603-bh198xgl	908	18	RNase	RNase	NNP
cord-259603-bh198xgl	908	19	A	a	DT
cord-259603-bh198xgl	908	20	occupy	occupy	VBP
cord-259603-bh198xgl	908	21	similar	similar	JJ
cord-259603-bh198xgl	908	22	positions	position	NNS
cord-259603-bh198xgl	908	23	in	in	IN
cord-259603-bh198xgl	908	24	the	the	DT
cord-259603-bh198xgl	908	25	active	active	JJ
cord-259603-bh198xgl	908	26	-	-	HYPH
cord-259603-bh198xgl	908	27	site	site	NN
cord-259603-bh198xgl	908	28	clefts	cleft	NNS
cord-259603-bh198xgl	908	29	of	of	IN
cord-259603-bh198xgl	908	30	the	the	DT
cord-259603-bh198xgl	908	31	two	two	CD
cord-259603-bh198xgl	908	32	enzymes	enzyme	NNS
cord-259603-bh198xgl	908	33	(	(	-LRB-
cord-259603-bh198xgl	908	34	Ulferts	Ulferts	NNP
cord-259603-bh198xgl	908	35	and	and	CC
cord-259603-bh198xgl	908	36	Ziebuhr	Ziebuhr	NNP
cord-259603-bh198xgl	908	37	,	,	,
cord-259603-bh198xgl	908	38	2011	2011	CD
cord-259603-bh198xgl	908	39	)	)	-RRB-
cord-259603-bh198xgl	908	40	.	.	.
cord-259603-bh198xgl	909	1	The	the	DT
cord-259603-bh198xgl	909	2	Ser	Ser	NNP
cord-259603-bh198xgl	909	3	/	/	SYM
cord-259603-bh198xgl	909	4	Thr	Thr	NNP
cord-259603-bh198xgl	909	5	residue	residue	NN
cord-259603-bh198xgl	909	6	is	be	VBZ
cord-259603-bh198xgl	909	7	conserved	conserve	VBN
cord-259603-bh198xgl	909	8	in	in	IN
cord-259603-bh198xgl	909	9	viral	viral	JJ
cord-259603-bh198xgl	909	10	and	and	CC
cord-259603-bh198xgl	909	11	cellular	cellular	JJ
cord-259603-bh198xgl	909	12	domains	domain	NNS
cord-259603-bh198xgl	909	13	,	,	,
cord-259603-bh198xgl	909	14	while	while	IN
cord-259603-bh198xgl	909	15	Tyr-342	Tyr-342	NNP
cord-259603-bh198xgl	909	16	is	be	VBZ
cord-259603-bh198xgl	909	17	conserved	conserve	VBN
cord-259603-bh198xgl	909	18	in	in	IN
cord-259603-bh198xgl	909	19	viral	viral	JJ
cord-259603-bh198xgl	909	20	endoU	endoU	NNP
cord-259603-bh198xgl	909	21	homologs	homolog	NNS
cord-259603-bh198xgl	909	22	while	while	IN
cord-259603-bh198xgl	909	23	conservative	conservative	JJ
cord-259603-bh198xgl	909	24	substitutions	substitution	NNS
cord-259603-bh198xgl	909	25	(	(	-LRB-
cord-259603-bh198xgl	909	26	Phe	Phe	NNP
cord-259603-bh198xgl	909	27	,	,	,
cord-259603-bh198xgl	909	28	Trp	Trp	NNP
cord-259603-bh198xgl	909	29	)	)	-RRB-
cord-259603-bh198xgl	909	30	are	be	VBP
cord-259603-bh198xgl	909	31	occasionally	occasionally	RB
cord-259603-bh198xgl	909	32	found	find	VBN
cord-259603-bh198xgl	909	33	in	in	IN
cord-259603-bh198xgl	909	34	cellular	cellular	JJ
cord-259603-bh198xgl	909	35	endoU	endoU	NNP
cord-259603-bh198xgl	909	36	homologs	homolog	NNS
cord-259603-bh198xgl	909	37	(	(	-LRB-
cord-259603-bh198xgl	909	38	Renzi	Renzi	NNP
cord-259603-bh198xgl	909	39	et	et	NNP
cord-259603-bh198xgl	909	40	al	al	NNP
cord-259603-bh198xgl	909	41	.	.	NNP
cord-259603-bh198xgl	909	42	,	,	,
cord-259603-bh198xgl	909	43	2006	2006	CD
cord-259603-bh198xgl	909	44	;	;	.
cord-259603-bh198xgl	910	1	Ricagno	Ricagno	NNP
cord-259603-bh198xgl	910	2	et	et	FW
cord-259603-bh198xgl	910	3	al	al	NNP
cord-259603-bh198xgl	910	4	.	.	NNP
cord-259603-bh198xgl	910	5	,	,	,
cord-259603-bh198xgl	910	6	2006	2006	CD
cord-259603-bh198xgl	910	7	)	)	-RRB-
cord-259603-bh198xgl	910	8	.	.	.
cord-259603-bh198xgl	911	1	The	the	DT
cord-259603-bh198xgl	911	2	role	role	NN
cord-259603-bh198xgl	911	3	of	of	IN
cord-259603-bh198xgl	911	4	SARS	SARS	NNP
cord-259603-bh198xgl	911	5	-	-	HYPH
cord-259603-bh198xgl	911	6	CoV	CoV	NNP
cord-259603-bh198xgl	911	7	endoU	endoU	NNP
cord-259603-bh198xgl	911	8	Ser-293	Ser-293	NNP
cord-259603-bh198xgl	911	9	and	and	CC
cord-259603-bh198xgl	911	10	Tyr-342	Tyr-342	NNP
cord-259603-bh198xgl	911	11	(	(	-LRB-
cord-259603-bh198xgl	911	12	and	and	CC
cord-259603-bh198xgl	911	13	equivalent	equivalent	JJ
cord-259603-bh198xgl	911	14	residues	residue	NNS
cord-259603-bh198xgl	911	15	in	in	IN
cord-259603-bh198xgl	911	16	related	related	JJ
cord-259603-bh198xgl	911	17	enzymes	enzyme	NNS
cord-259603-bh198xgl	911	18	)	)	-RRB-
cord-259603-bh198xgl	911	19	in	in	IN
cord-259603-bh198xgl	911	20	substrate	substrate	NN
cord-259603-bh198xgl	911	21	binding	bind	VBG
cord-259603-bh198xgl	911	22	received	receive	VBD
cord-259603-bh198xgl	911	23	strong	strong	JJ
cord-259603-bh198xgl	911	24	support	support	NN
cord-259603-bh198xgl	911	25	by	by	IN
cord-259603-bh198xgl	911	26	molecular	molecular	JJ
cord-259603-bh198xgl	911	27	modeling	modeling	NN
cord-259603-bh198xgl	911	28	and	and	CC
cord-259603-bh198xgl	911	29	site	site	NN
cord-259603-bh198xgl	911	30	-	-	HYPH
cord-259603-bh198xgl	911	31	directed	direct	VBN
cord-259603-bh198xgl	911	32	mutagenesis	mutagenesis	NN
cord-259603-bh198xgl	911	33	data	datum	NNS
cord-259603-bh198xgl	911	34	,	,	,
cord-259603-bh198xgl	911	35	with	with	IN
cord-259603-bh198xgl	911	36	the	the	DT
cord-259603-bh198xgl	911	37	conserved	conserve	VBN
cord-259603-bh198xgl	911	38	Ser	Ser	NNP
cord-259603-bh198xgl	911	39	/	/	SYM
cord-259603-bh198xgl	911	40	Thr	Thr	NNP
cord-259603-bh198xgl	911	41	residue	residue	NN
cord-259603-bh198xgl	911	42	being	be	VBG
cord-259603-bh198xgl	911	43	confirmed	confirm	VBN
cord-259603-bh198xgl	911	44	to	to	TO
cord-259603-bh198xgl	911	45	have	have	VB
cord-259603-bh198xgl	911	46	a	a	DT
cord-259603-bh198xgl	911	47	critical	critical	JJ
cord-259603-bh198xgl	911	48	role	role	NN
cord-259603-bh198xgl	911	49	in	in	IN
cord-259603-bh198xgl	911	50	the	the	DT
cord-259603-bh198xgl	911	51	differential	differential	JJ
cord-259603-bh198xgl	911	52	cleavage	cleavage	NN
cord-259603-bh198xgl	911	53	of	of	IN
cord-259603-bh198xgl	911	54	uridine	uridine	NN
cord-259603-bh198xgl	911	55	-	-	HYPH
cord-259603-bh198xgl	911	56	and	and	CC
cord-259603-bh198xgl	911	57	cytidinecontaining	cytidinecontaining	NN
cord-259603-bh198xgl	911	58	substrates	substrate	NNS
cord-259603-bh198xgl	911	59	,	,	,
cord-259603-bh198xgl	911	60	respectively	respectively	RB
cord-259603-bh198xgl	911	61	(	(	-LRB-
cord-259603-bh198xgl	911	62	Bhardwaj	Bhardwaj	NNP
cord-259603-bh198xgl	911	63	et	et	NNP
cord-259603-bh198xgl	911	64	al	al	NNP
cord-259603-bh198xgl	911	65	.	.	NNP
cord-259603-bh198xgl	911	66	,	,	,
cord-259603-bh198xgl	911	67	2008	2008	CD
cord-259603-bh198xgl	911	68	;	;	.
cord-259603-bh198xgl	912	1	Nedialkova	Nedialkova	NNP
cord-259603-bh198xgl	912	2	et	et	NNP
cord-259603-bh198xgl	912	3	al	al	NNP
cord-259603-bh198xgl	912	4	.	.	.
cord-259603-bh198xgl	913	1	,	,	,
cord-259603-bh198xgl	913	2	2009	2009	CD
cord-259603-bh198xgl	913	3	;	;	:
cord-259603-bh198xgl	913	4	Ricagno	Ricagno	NNP
cord-259603-bh198xgl	913	5	et	et	FW
cord-259603-bh198xgl	913	6	al	al	NNP
cord-259603-bh198xgl	913	7	.	.	NNP
cord-259603-bh198xgl	913	8	,	,	,
cord-259603-bh198xgl	913	9	2006	2006	CD
cord-259603-bh198xgl	913	10	)	)	-RRB-
cord-259603-bh198xgl	913	11	.	.	.
cord-259603-bh198xgl	914	1	Similarities	similarity	NNS
cord-259603-bh198xgl	914	2	in	in	IN
cord-259603-bh198xgl	914	3	their	-PRON-	PRP$
cord-259603-bh198xgl	914	4	active	active	JJ
cord-259603-bh198xgl	914	5	-	-	HYPH
cord-259603-bh198xgl	914	6	site	site	NN
cord-259603-bh198xgl	914	7	structures	structure	NNS
cord-259603-bh198xgl	914	8	and	and	CC
cord-259603-bh198xgl	914	9	reaction	reaction	NN
cord-259603-bh198xgl	914	10	products	product	NNS
cord-259603-bh198xgl	914	11	containing	contain	VBG
cord-259603-bh198xgl	914	12	2	2	CD
cord-259603-bh198xgl	914	13	0	0	CD
cord-259603-bh198xgl	914	14	,	,	,
cord-259603-bh198xgl	914	15	3	3	CD
cord-259603-bh198xgl	914	16	0	0	CD
cord-259603-bh198xgl	914	17	-cyclic	-cyclic	JJ
cord-259603-bh198xgl	914	18	phosphate	phosphate	NN
cord-259603-bh198xgl	914	19	ends	end	NNS
cord-259603-bh198xgl	914	20	suggest	suggest	VBP
cord-259603-bh198xgl	914	21	that	that	IN
cord-259603-bh198xgl	914	22	endoUs	endous	JJ
cord-259603-bh198xgl	914	23	and	and	CC
cord-259603-bh198xgl	914	24	RNase	RNase	NNP
cord-259603-bh198xgl	914	25	A	A	NNP
cord-259603-bh198xgl	914	26	-	-	HYPH
cord-259603-bh198xgl	914	27	like	like	JJ
cord-259603-bh198xgl	914	28	endoribonucleases	endoribonuclease	NNS
cord-259603-bh198xgl	914	29	employ	employ	VBP
cord-259603-bh198xgl	914	30	similar	similar	JJ
cord-259603-bh198xgl	914	31	catalytic	catalytic	JJ
cord-259603-bh198xgl	914	32	mechanisms	mechanism	NNS
cord-259603-bh198xgl	914	33	(	(	-LRB-
cord-259603-bh198xgl	914	34	Nedialkova	Nedialkova	NNP
cord-259603-bh198xgl	914	35	et	et	NNP
cord-259603-bh198xgl	914	36	al	al	NNP
cord-259603-bh198xgl	914	37	.	.	NNP
cord-259603-bh198xgl	914	38	,	,	,
cord-259603-bh198xgl	914	39	2009	2009	CD
cord-259603-bh198xgl	914	40	;	;	:
cord-259603-bh198xgl	914	41	Ricagno	Ricagno	NNP
cord-259603-bh198xgl	914	42	et	et	FW
cord-259603-bh198xgl	914	43	al	al	NNP
cord-259603-bh198xgl	914	44	.	.	NNP
cord-259603-bh198xgl	914	45	,	,	,
cord-259603-bh198xgl	914	46	2006	2006	CD
cord-259603-bh198xgl	914	47	)	)	-RRB-
cord-259603-bh198xgl	914	48	.	.	.
cord-259603-bh198xgl	915	1	For	for	IN
cord-259603-bh198xgl	915	2	RNase	RNase	NNP
cord-259603-bh198xgl	915	3	A	A	NNP
cord-259603-bh198xgl	915	4	,	,	,
cord-259603-bh198xgl	915	5	it	-PRON-	PRP
cord-259603-bh198xgl	915	6	has	have	VBZ
cord-259603-bh198xgl	915	7	been	be	VBN
cord-259603-bh198xgl	915	8	established	establish	VBN
cord-259603-bh198xgl	915	9	that	that	IN
cord-259603-bh198xgl	915	10	two	two	CD
cord-259603-bh198xgl	915	11	His	-PRON-	PRP$
cord-259603-bh198xgl	915	12	residues	residue	NNS
cord-259603-bh198xgl	915	13	in	in	IN
cord-259603-bh198xgl	915	14	the	the	DT
cord-259603-bh198xgl	915	15	active	active	JJ
cord-259603-bh198xgl	915	16	site	site	NN
cord-259603-bh198xgl	915	17	act	act	NN
cord-259603-bh198xgl	915	18	as	as	IN
cord-259603-bh198xgl	915	19	general	general	JJ
cord-259603-bh198xgl	915	20	base	base	NN
cord-259603-bh198xgl	915	21	and	and	CC
cord-259603-bh198xgl	915	22	acid	acid	NN
cord-259603-bh198xgl	915	23	,	,	,
cord-259603-bh198xgl	915	24	respectively	respectively	RB
cord-259603-bh198xgl	915	25	.	.	.
cord-259603-bh198xgl	916	1	The	the	DT
cord-259603-bh198xgl	916	2	His	-PRON-	PRP$
cord-259603-bh198xgl	916	3	residue	residue	NN
cord-259603-bh198xgl	916	4	that	that	WDT
cord-259603-bh198xgl	916	5	acts	act	VBZ
cord-259603-bh198xgl	916	6	as	as	IN
cord-259603-bh198xgl	916	7	a	a	DT
cord-259603-bh198xgl	916	8	general	general	JJ
cord-259603-bh198xgl	916	9	base	base	NN
cord-259603-bh198xgl	916	10	attracts	attract	VBZ
cord-259603-bh198xgl	916	11	a	a	DT
cord-259603-bh198xgl	916	12	hydrogen	hydrogen	NN
cord-259603-bh198xgl	916	13	from	from	IN
cord-259603-bh198xgl	916	14	the	the	DT
cord-259603-bh198xgl	916	15	ribose	ribose	NN
cord-259603-bh198xgl	916	16	2	2	CD
cord-259603-bh198xgl	916	17	0	0	CD
cord-259603-bh198xgl	916	18	-hydroxyl	-hydroxyl	CD
cord-259603-bh198xgl	916	19	group	group	NN
cord-259603-bh198xgl	916	20	that	that	WDT
cord-259603-bh198xgl	916	21	subsequently	subsequently	RB
cord-259603-bh198xgl	916	22	attacks	attack	VBZ
cord-259603-bh198xgl	916	23	the	the	DT
cord-259603-bh198xgl	916	24	5	5	CD
cord-259603-bh198xgl	916	25	0	0	CD
cord-259603-bh198xgl	916	26	P	p	NN
cord-259603-bh198xgl	916	27	-	-	HYPH
cord-259603-bh198xgl	916	28	O	o	NN
cord-259603-bh198xgl	916	29	bond	bond	NN
cord-259603-bh198xgl	916	30	.	.	.
cord-259603-bh198xgl	917	1	The	the	DT
cord-259603-bh198xgl	917	2	second	second	JJ
cord-259603-bh198xgl	917	3	His	-PRON-	PRP$
cord-259603-bh198xgl	917	4	donates	donate	VBZ
cord-259603-bh198xgl	917	5	a	a	DT
cord-259603-bh198xgl	917	6	hydrogen	hydrogen	NN
cord-259603-bh198xgl	917	7	to	to	IN
cord-259603-bh198xgl	917	8	the	the	DT
cord-259603-bh198xgl	917	9	5	5	CD
cord-259603-bh198xgl	917	10	0	0	CD
cord-259603-bh198xgl	917	11	-O	-o	CD
cord-259603-bh198xgl	917	12	,	,	,
cord-259603-bh198xgl	917	13	thus	thus	RB
cord-259603-bh198xgl	917	14	facilitating	facilitate	VBG
cord-259603-bh198xgl	917	15	displacement	displacement	NN
cord-259603-bh198xgl	917	16	of	of	IN
cord-259603-bh198xgl	917	17	this	this	DT
cord-259603-bh198xgl	917	18	group	group	NN
cord-259603-bh198xgl	917	19	and	and	CC
cord-259603-bh198xgl	917	20	subsequent	subsequent	JJ
cord-259603-bh198xgl	917	21	product	product	NN
cord-259603-bh198xgl	917	22	release	release	NN
cord-259603-bh198xgl	917	23	(	(	-LRB-
cord-259603-bh198xgl	917	24	Raines	Raines	NNP
cord-259603-bh198xgl	917	25	,	,	,
cord-259603-bh198xgl	917	26	1998	1998	CD
cord-259603-bh198xgl	917	27	)	)	-RRB-
cord-259603-bh198xgl	917	28	.	.	.
cord-259603-bh198xgl	918	1	In	in	IN
cord-259603-bh198xgl	918	2	a	a	DT
cord-259603-bh198xgl	918	3	second	second	JJ
cord-259603-bh198xgl	918	4	step	step	NN
cord-259603-bh198xgl	918	5	,	,	,
cord-259603-bh198xgl	918	6	the	the	DT
cord-259603-bh198xgl	918	7	2	2	CD
cord-259603-bh198xgl	918	8	0	0	CD
cord-259603-bh198xgl	918	9	,	,	,
cord-259603-bh198xgl	918	10	3	3	CD
cord-259603-bh198xgl	918	11	0	0	CD
cord-259603-bh198xgl	918	12	-cyclic	-cyclic	JJ
cord-259603-bh198xgl	918	13	phosphate	phosphate	NN
cord-259603-bh198xgl	918	14	is	be	VBZ
cord-259603-bh198xgl	918	15	hydrolyzed	hydrolyze	VBN
cord-259603-bh198xgl	918	16	,	,	,
cord-259603-bh198xgl	918	17	resulting	result	VBG
cord-259603-bh198xgl	918	18	in	in	IN
cord-259603-bh198xgl	918	19	a	a	DT
cord-259603-bh198xgl	918	20	3	3	CD
cord-259603-bh198xgl	918	21	0	0	CD
cord-259603-bh198xgl	918	22	-phosphomonoester	-phosphomonoester	NN
cord-259603-bh198xgl	918	23	product	product	NN
cord-259603-bh198xgl	918	24	and	and	CC
cord-259603-bh198xgl	918	25	recovery	recovery	NN
cord-259603-bh198xgl	918	26	of	of	IN
cord-259603-bh198xgl	918	27	the	the	DT
cord-259603-bh198xgl	918	28	enzyme	enzyme	NN
cord-259603-bh198xgl	918	29	.	.	.
cord-259603-bh198xgl	919	1	The	the	DT
cord-259603-bh198xgl	919	2	latter	latter	JJ
cord-259603-bh198xgl	919	3	is	be	VBZ
cord-259603-bh198xgl	919	4	essentially	essentially	RB
cord-259603-bh198xgl	919	5	a	a	DT
cord-259603-bh198xgl	919	6	reverse	reverse	JJ
cord-259603-bh198xgl	919	7	reaction	reaction	NN
cord-259603-bh198xgl	919	8	of	of	IN
cord-259603-bh198xgl	919	9	the	the	DT
cord-259603-bh198xgl	919	10	transphosphorylation	transphosphorylation	NN
cord-259603-bh198xgl	919	11	reaction	reaction	NN
cord-259603-bh198xgl	919	12	,	,	,
cord-259603-bh198xgl	919	13	with	with	IN
cord-259603-bh198xgl	919	14	the	the	DT
cord-259603-bh198xgl	919	15	protonated	protonated	JJ
cord-259603-bh198xgl	919	16	His	-PRON-	PRP$
cord-259603-bh198xgl	919	17	now	now	RB
cord-259603-bh198xgl	919	18	acting	act	VBG
cord-259603-bh198xgl	919	19	as	as	IN
cord-259603-bh198xgl	919	20	an	an	DT
cord-259603-bh198xgl	919	21	acid	acid	NN
cord-259603-bh198xgl	919	22	and	and	CC
cord-259603-bh198xgl	919	23	the	the	DT
cord-259603-bh198xgl	919	24	other	other	JJ
cord-259603-bh198xgl	920	1	His	-PRON-	PRP$
cord-259603-bh198xgl	920	2	acting	acting	NN
cord-259603-bh198xgl	920	3	as	as	IN
cord-259603-bh198xgl	920	4	a	a	DT
cord-259603-bh198xgl	920	5	base	base	NN
cord-259603-bh198xgl	920	6	.	.	.
cord-259603-bh198xgl	921	1	In	in	IN
cord-259603-bh198xgl	921	2	both	both	DT
cord-259603-bh198xgl	921	3	reaction	reaction	NN
cord-259603-bh198xgl	921	4	steps	step	NNS
cord-259603-bh198xgl	921	5	,	,	,
cord-259603-bh198xgl	921	6	Lys	Lys	NNP
cord-259603-bh198xgl	921	7	interacts	interact	VBZ
cord-259603-bh198xgl	921	8	with	with	IN
cord-259603-bh198xgl	921	9	the	the	DT
cord-259603-bh198xgl	921	10	phosphate	phosphate	NN
cord-259603-bh198xgl	921	11	to	to	TO
cord-259603-bh198xgl	921	12	stabilize	stabilize	VB
cord-259603-bh198xgl	921	13	the	the	DT
cord-259603-bh198xgl	921	14	pentavalent	pentavalent	JJ
cord-259603-bh198xgl	921	15	reaction	reaction	NN
cord-259603-bh198xgl	921	16	intermediate	intermediate	JJ
cord-259603-bh198xgl	921	17	.	.	.
cord-259603-bh198xgl	922	1	Although	although	IN
cord-259603-bh198xgl	922	2	the	the	DT
cord-259603-bh198xgl	922	3	reaction	reaction	NN
cord-259603-bh198xgl	922	4	mechanisms	mechanism	NNS
cord-259603-bh198xgl	922	5	employed	employ	VBN
cord-259603-bh198xgl	922	6	by	by	IN
cord-259603-bh198xgl	922	7	endoUs	endous	CD
cord-259603-bh198xgl	922	8	have	have	VBP
cord-259603-bh198xgl	922	9	not	not	RB
cord-259603-bh198xgl	922	10	been	be	VBN
cord-259603-bh198xgl	922	11	studied	study	VBN
cord-259603-bh198xgl	922	12	in	in	IN
cord-259603-bh198xgl	922	13	detail	detail	NN
cord-259603-bh198xgl	922	14	,	,	,
cord-259603-bh198xgl	922	15	the	the	DT
cord-259603-bh198xgl	922	16	enzymes	enzyme	NNS
cord-259603-bh198xgl	922	17	are	be	VBP
cord-259603-bh198xgl	922	18	thought	think	VBN
cord-259603-bh198xgl	922	19	to	to	TO
cord-259603-bh198xgl	922	20	use	use	VB
cord-259603-bh198xgl	922	21	an	an	DT
cord-259603-bh198xgl	922	22	RNase	rnase	NN
cord-259603-bh198xgl	922	23	A	a	NN
cord-259603-bh198xgl	922	24	-	-	HYPH
cord-259603-bh198xgl	922	25	like	like	JJ
cord-259603-bh198xgl	922	26	catalytic	catalytic	JJ
cord-259603-bh198xgl	922	27	mechanism	mechanism	NN
cord-259603-bh198xgl	922	28	.	.	.
cord-259603-bh198xgl	923	1	This	this	DT
cord-259603-bh198xgl	923	2	is	be	VBZ
cord-259603-bh198xgl	923	3	supported	support	VBN
cord-259603-bh198xgl	923	4	by	by	IN
cord-259603-bh198xgl	923	5	several	several	JJ
cord-259603-bh198xgl	923	6	lines	line	NNS
cord-259603-bh198xgl	923	7	of	of	IN
cord-259603-bh198xgl	923	8	evidence	evidence	NN
cord-259603-bh198xgl	923	9	,	,	,
cord-259603-bh198xgl	923	10	including	include	VBG
cord-259603-bh198xgl	923	11	(	(	-LRB-
cord-259603-bh198xgl	923	12	i	i	NN
cord-259603-bh198xgl	923	13	)	)	-RRB-
cord-259603-bh198xgl	923	14	the	the	DT
cord-259603-bh198xgl	923	15	conserved	conserve	VBN
cord-259603-bh198xgl	923	16	spatial	spatial	JJ
cord-259603-bh198xgl	923	17	positions	position	NNS
cord-259603-bh198xgl	923	18	in	in	IN
cord-259603-bh198xgl	923	19	the	the	DT
cord-259603-bh198xgl	923	20	structure	structure	NN
cord-259603-bh198xgl	923	21	and	and	CC
cord-259603-bh198xgl	923	22	the	the	DT
cord-259603-bh198xgl	923	23	critical	critical	JJ
cord-259603-bh198xgl	923	24	functional	functional	JJ
cord-259603-bh198xgl	923	25	role	role	NN
cord-259603-bh198xgl	923	26	of	of	IN
cord-259603-bh198xgl	923	27	two	two	CD
cord-259603-bh198xgl	923	28	His	-PRON-	PRP$
cord-259603-bh198xgl	923	29	and	and	CC
cord-259603-bh198xgl	923	30	one	one	CD
cord-259603-bh198xgl	923	31	Lys	Lys	NNP
cord-259603-bh198xgl	923	32	residue(s	residue(s	NNP
cord-259603-bh198xgl	923	33	)	)	-RRB-
cord-259603-bh198xgl	923	34	(	(	-LRB-
cord-259603-bh198xgl	923	35	Ricagno	Ricagno	NNP
cord-259603-bh198xgl	923	36	et	et	FW
cord-259603-bh198xgl	923	37	al	al	NNP
cord-259603-bh198xgl	923	38	.	.	NNP
cord-259603-bh198xgl	923	39	,	,	,
cord-259603-bh198xgl	923	40	2006	2006	CD
cord-259603-bh198xgl	923	41	)	)	-RRB-
cord-259603-bh198xgl	923	42	,	,	,
cord-259603-bh198xgl	923	43	and	and	CC
cord-259603-bh198xgl	923	44	(	(	-LRB-
cord-259603-bh198xgl	923	45	ii	ii	NN
cord-259603-bh198xgl	923	46	)	)	-RRB-
cord-259603-bh198xgl	923	47	the	the	DT
cord-259603-bh198xgl	923	48	release	release	NN
cord-259603-bh198xgl	923	49	of	of	IN
cord-259603-bh198xgl	923	50	2	2	CD
cord-259603-bh198xgl	923	51	0	0	CD
cord-259603-bh198xgl	923	52	,	,	,
cord-259603-bh198xgl	923	53	3	3	CD
cord-259603-bh198xgl	923	54	0	0	CD
cord-259603-bh198xgl	923	55	-cyclic	-cyclic	JJ
cord-259603-bh198xgl	923	56	phosphate	phosphate	NN
cord-259603-bh198xgl	923	57	-	-	HYPH
cord-259603-bh198xgl	923	58	containing	contain	VBG
cord-259603-bh198xgl	923	59	reaction	reaction	NN
cord-259603-bh198xgl	923	60	products	product	NNS
cord-259603-bh198xgl	923	61	(	(	-LRB-
cord-259603-bh198xgl	923	62	Bhardwaj	Bhardwaj	NNP
cord-259603-bh198xgl	923	63	et	et	NNP
cord-259603-bh198xgl	923	64	al	al	NNP
cord-259603-bh198xgl	923	65	.	.	NNP
cord-259603-bh198xgl	923	66	,	,	,
cord-259603-bh198xgl	923	67	2004	2004	CD
cord-259603-bh198xgl	923	68	;	;	:
cord-259603-bh198xgl	923	69	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	923	70	et	et	NNP
cord-259603-bh198xgl	923	71	al	al	NNP
cord-259603-bh198xgl	923	72	.	.	NNP
cord-259603-bh198xgl	923	73	,	,	,
cord-259603-bh198xgl	923	74	2004a	2004a	CD
cord-259603-bh198xgl	923	75	)	)	-RRB-
cord-259603-bh198xgl	923	76	that	that	WDT
cord-259603-bh198xgl	923	77	are	be	VBP
cord-259603-bh198xgl	923	78	converted	convert	VBN
cord-259603-bh198xgl	923	79	to	to	IN
cord-259603-bh198xgl	923	80	products	product	NNS
cord-259603-bh198xgl	923	81	with	with	IN
cord-259603-bh198xgl	923	82	3	3	CD
cord-259603-bh198xgl	923	83	0	0	CD
cord-259603-bh198xgl	923	84	-hydroxyl	-hydroxyl	NN
cord-259603-bh198xgl	923	85	ends	end	NNS
cord-259603-bh198xgl	923	86	(	(	-LRB-
cord-259603-bh198xgl	923	87	Nedialkova	Nedialkova	NNP
cord-259603-bh198xgl	923	88	et	et	NNP
cord-259603-bh198xgl	923	89	al	al	NNP
cord-259603-bh198xgl	923	90	.	.	NNP
cord-259603-bh198xgl	923	91	,	,	,
cord-259603-bh198xgl	923	92	2009	2009	CD
cord-259603-bh198xgl	923	93	)	)	-RRB-
cord-259603-bh198xgl	923	94	.	.	.
cord-259603-bh198xgl	924	1	Since	since	IN
cord-259603-bh198xgl	924	2	the	the	DT
cord-259603-bh198xgl	924	3	first	first	JJ
cord-259603-bh198xgl	924	4	in	in	IN
cord-259603-bh198xgl	924	5	-	-	HYPH
cord-259603-bh198xgl	924	6	depth	depth	NN
cord-259603-bh198xgl	924	7	analysis	analysis	NN
cord-259603-bh198xgl	924	8	of	of	IN
cord-259603-bh198xgl	924	9	a	a	DT
cord-259603-bh198xgl	924	10	CoV	cov	NN
cord-259603-bh198xgl	924	11	replicase	replicase	NN
cord-259603-bh198xgl	924	12	in	in	IN
cord-259603-bh198xgl	924	13	1989	1989	CD
cord-259603-bh198xgl	924	14	(	(	-LRB-
cord-259603-bh198xgl	924	15	Gorbalenya	Gorbalenya	NNP
cord-259603-bh198xgl	924	16	et	et	NNP
cord-259603-bh198xgl	924	17	al	al	NNP
cord-259603-bh198xgl	924	18	.	.	NNP
cord-259603-bh198xgl	924	19	,	,	,
cord-259603-bh198xgl	924	20	1989	1989	CD
cord-259603-bh198xgl	924	21	)	)	-RRB-
cord-259603-bh198xgl	924	22	,	,	,
cord-259603-bh198xgl	924	23	significant	significant	JJ
cord-259603-bh198xgl	924	24	progress	progress	NN
cord-259603-bh198xgl	924	25	has	have	VBZ
cord-259603-bh198xgl	924	26	been	be	VBN
cord-259603-bh198xgl	924	27	made	make	VBN
cord-259603-bh198xgl	924	28	in	in	IN
cord-259603-bh198xgl	924	29	terms	term	NNS
cord-259603-bh198xgl	924	30	of	of	IN
cord-259603-bh198xgl	924	31	its	-PRON-	PRP$
cord-259603-bh198xgl	924	32	structural	structural	JJ
cord-259603-bh198xgl	924	33	and	and	CC
cord-259603-bh198xgl	924	34	functional	functional	JJ
cord-259603-bh198xgl	924	35	characterization	characterization	NN
cord-259603-bh198xgl	924	36	.	.	.
cord-259603-bh198xgl	925	1	A	a	DT
cord-259603-bh198xgl	925	2	multitude	multitude	NN
cord-259603-bh198xgl	925	3	of	of	IN
cord-259603-bh198xgl	925	4	enzymatic	enzymatic	JJ
cord-259603-bh198xgl	925	5	functions	function	NNS
cord-259603-bh198xgl	925	6	has	have	VBZ
cord-259603-bh198xgl	925	7	been	be	VBN
cord-259603-bh198xgl	925	8	identified	identify	VBN
cord-259603-bh198xgl	925	9	and	and	CC
cord-259603-bh198xgl	925	10	characterized	characterize	VBN
cord-259603-bh198xgl	925	11	in	in	IN
cord-259603-bh198xgl	925	12	vitro	vitro	FW
cord-259603-bh198xgl	925	13	,	,	,
cord-259603-bh198xgl	925	14	although	although	IN
cord-259603-bh198xgl	925	15	mainly	mainly	RB
cord-259603-bh198xgl	925	16	using	use	VBG
cord-259603-bh198xgl	925	17	artificial	artificial	JJ
cord-259603-bh198xgl	925	18	substrates	substrate	NNS
cord-259603-bh198xgl	925	19	so	so	RB
cord-259603-bh198xgl	925	20	far	far	RB
cord-259603-bh198xgl	925	21	.	.	.
cord-259603-bh198xgl	926	1	Protein	protein	NN
cord-259603-bh198xgl	926	2	structures	structure	NNS
cord-259603-bh198xgl	926	3	were	be	VBD
cord-259603-bh198xgl	926	4	obtained	obtain	VBN
cord-259603-bh198xgl	926	5	for	for	IN
cord-259603-bh198xgl	926	6	most	most	JJS
cord-259603-bh198xgl	926	7	of	of	IN
cord-259603-bh198xgl	926	8	the	the	DT
cord-259603-bh198xgl	926	9	subunits	subunit	NNS
cord-259603-bh198xgl	926	10	from	from	IN
cord-259603-bh198xgl	926	11	the	the	DT
cord-259603-bh198xgl	926	12	nsp7	nsp7	NNP
cord-259603-bh198xgl	926	13	-	-	HYPH
cord-259603-bh198xgl	926	14	16	16	CD
cord-259603-bh198xgl	926	15	region	region	NN
cord-259603-bh198xgl	926	16	(	(	-LRB-
cord-259603-bh198xgl	926	17	Neuman	Neuman	NNP
cord-259603-bh198xgl	926	18	et	et	NNP
cord-259603-bh198xgl	926	19	al	al	NNP
cord-259603-bh198xgl	926	20	.	.	NNP
cord-259603-bh198xgl	926	21	,	,	,
cord-259603-bh198xgl	926	22	2014b	2014b	CD
cord-259603-bh198xgl	926	23	)	)	-RRB-
cord-259603-bh198xgl	926	24	,	,	,
cord-259603-bh198xgl	926	25	but	but	CC
cord-259603-bh198xgl	926	26	unfortunately	unfortunately	RB
cord-259603-bh198xgl	926	27	two	two	CD
cord-259603-bh198xgl	926	28	prominent	prominent	JJ
cord-259603-bh198xgl	926	29	remaining	remain	VBG
cord-259603-bh198xgl	926	30	"	"	``
cord-259603-bh198xgl	926	31	blank	blank	JJ
cord-259603-bh198xgl	926	32	spots	spot	NNS
cord-259603-bh198xgl	926	33	"	"	''
cord-259603-bh198xgl	926	34	on	on	IN
cord-259603-bh198xgl	926	35	this	this	DT
cord-259603-bh198xgl	926	36	map	map	NN
cord-259603-bh198xgl	926	37	concern	concern	NN
cord-259603-bh198xgl	926	38	two	two	CD
cord-259603-bh198xgl	926	39	key	key	JJ
cord-259603-bh198xgl	926	40	enzymes	enzyme	NNS
cord-259603-bh198xgl	926	41	in	in	IN
cord-259603-bh198xgl	926	42	CoV	CoV	NNP
cord-259603-bh198xgl	926	43	RNA	RNA	NNP
cord-259603-bh198xgl	926	44	synthesis	synthesis	NN
cord-259603-bh198xgl	926	45	,	,	,
cord-259603-bh198xgl	926	46	RdRp	RdRp	NNP
cord-259603-bh198xgl	926	47	and	and	CC
cord-259603-bh198xgl	926	48	helicase	helicase	NNP
cord-259603-bh198xgl	926	49	.	.	.
cord-259603-bh198xgl	927	1	Filling	fill	VBG
cord-259603-bh198xgl	927	2	those	those	DT
cord-259603-bh198xgl	927	3	gaps	gap	NNS
cord-259603-bh198xgl	927	4	would	would	MD
cord-259603-bh198xgl	927	5	constitute	constitute	VB
cord-259603-bh198xgl	927	6	an	an	DT
cord-259603-bh198xgl	927	7	important	important	JJ
cord-259603-bh198xgl	927	8	step	step	NN
cord-259603-bh198xgl	927	9	forward	forward	RB
cord-259603-bh198xgl	927	10	,	,	,
cord-259603-bh198xgl	927	11	to	to	TO
cord-259603-bh198xgl	927	12	address	address	VB
cord-259603-bh198xgl	927	13	basic	basic	JJ
cord-259603-bh198xgl	927	14	questions	question	NNS
cord-259603-bh198xgl	927	15	like	like	IN
cord-259603-bh198xgl	927	16	the	the	DT
cord-259603-bh198xgl	927	17	priming	priming	NN
cord-259603-bh198xgl	927	18	mechanism	mechanism	NN
cord-259603-bh198xgl	927	19	employed	employ	VBN
cord-259603-bh198xgl	927	20	by	by	IN
cord-259603-bh198xgl	927	21	the	the	DT
cord-259603-bh198xgl	927	22	RdRp	RdRp	NNP
cord-259603-bh198xgl	927	23	and	and	CC
cord-259603-bh198xgl	927	24	the	the	DT
cord-259603-bh198xgl	927	25	function	function	NN
cord-259603-bh198xgl	927	26	of	of	IN
cord-259603-bh198xgl	927	27	the	the	DT
cord-259603-bh198xgl	927	28	NiRAN	NiRAN	NNP
cord-259603-bh198xgl	927	29	domain	domain	NN
cord-259603-bh198xgl	927	30	,	,	,
cord-259603-bh198xgl	927	31	and	and	CC
cord-259603-bh198xgl	927	32	to	to	TO
cord-259603-bh198xgl	927	33	accelerate	accelerate	VB
cord-259603-bh198xgl	927	34	targeted	target	VBN
cord-259603-bh198xgl	927	35	drug	drug	NN
cord-259603-bh198xgl	927	36	discovery	discovery	NN
cord-259603-bh198xgl	927	37	,	,	,
cord-259603-bh198xgl	927	38	for	for	IN
cord-259603-bh198xgl	927	39	example	example	NN
cord-259603-bh198xgl	927	40	,	,	,
cord-259603-bh198xgl	927	41	in	in	IN
cord-259603-bh198xgl	927	42	the	the	DT
cord-259603-bh198xgl	927	43	area	area	NN
cord-259603-bh198xgl	927	44	of	of	IN
cord-259603-bh198xgl	927	45	nucleoside	nucleoside	NN
cord-259603-bh198xgl	927	46	inhibitors	inhibitor	NNS
cord-259603-bh198xgl	927	47	of	of	IN
cord-259603-bh198xgl	927	48	CoV	CoV	NNP
cord-259603-bh198xgl	927	49	RNA	RNA	NNP
cord-259603-bh198xgl	927	50	synthesis	synthesis	NN
cord-259603-bh198xgl	927	51	,	,	,
cord-259603-bh198xgl	927	52	which	which	WDT
cord-259603-bh198xgl	927	53	has	have	VBZ
cord-259603-bh198xgl	927	54	received	receive	VBN
cord-259603-bh198xgl	927	55	little	little	JJ
cord-259603-bh198xgl	927	56	attention	attention	NN
cord-259603-bh198xgl	927	57	thus	thus	RB
cord-259603-bh198xgl	927	58	far	far	RB
cord-259603-bh198xgl	927	59	.	.	.
cord-259603-bh198xgl	928	1	Clearly	clearly	RB
cord-259603-bh198xgl	928	2	,	,	,
cord-259603-bh198xgl	928	3	where	where	WRB
cord-259603-bh198xgl	928	4	CoV	CoV	NNP
cord-259603-bh198xgl	928	5	mRNA	mRNA	NNP
cord-259603-bh198xgl	928	6	capping	capping	NN
cord-259603-bh198xgl	928	7	is	be	VBZ
cord-259603-bh198xgl	928	8	concerned	concern	VBN
cord-259603-bh198xgl	928	9	,	,	,
cord-259603-bh198xgl	928	10	identification	identification	NN
cord-259603-bh198xgl	928	11	of	of	IN
cord-259603-bh198xgl	928	12	the	the	DT
cord-259603-bh198xgl	928	13	elusive	elusive	JJ
cord-259603-bh198xgl	928	14	GTase	GTase	NNP
cord-259603-bh198xgl	928	15	remains	remain	VBZ
cord-259603-bh198xgl	928	16	a	a	DT
cord-259603-bh198xgl	928	17	research	research	NN
cord-259603-bh198xgl	928	18	priority	priority	NN
cord-259603-bh198xgl	929	1	(	(	-LRB-
cord-259603-bh198xgl	929	2	Subissi	Subissi	NNP
cord-259603-bh198xgl	929	3	et	et	NNP
cord-259603-bh198xgl	929	4	al	al	NNP
cord-259603-bh198xgl	929	5	.	.	.
cord-259603-bh198xgl	930	1	,	,	,
cord-259603-bh198xgl	930	2	2014a	2014a	CD
cord-259603-bh198xgl	930	3	)	)	-RRB-
cord-259603-bh198xgl	930	4	.	.	.
cord-259603-bh198xgl	931	1	For	for	IN
cord-259603-bh198xgl	931	2	other	other	JJ
cord-259603-bh198xgl	931	3	nsps	nsp	NNS
cord-259603-bh198xgl	931	4	,	,	,
cord-259603-bh198xgl	931	5	potential	potential	JJ
cord-259603-bh198xgl	931	6	functions	function	NNS
cord-259603-bh198xgl	931	7	(	(	-LRB-
cord-259603-bh198xgl	931	8	nsp9	nsp9	UH
cord-259603-bh198xgl	931	9	,	,	,
cord-259603-bh198xgl	931	10	the	the	DT
cord-259603-bh198xgl	931	11	N	n	CD
cord-259603-bh198xgl	931	12	-	-	HYPH
cord-259603-bh198xgl	931	13	terminal	terminal	NN
cord-259603-bh198xgl	931	14	domain	domain	NN
cord-259603-bh198xgl	931	15	of	of	IN
cord-259603-bh198xgl	931	16	nsp15	nsp15	CD
cord-259603-bh198xgl	931	17	)	)	-RRB-
cord-259603-bh198xgl	931	18	or	or	CC
cord-259603-bh198xgl	931	19	substrates	substrate	NNS
cord-259603-bh198xgl	931	20	(	(	-LRB-
cord-259603-bh198xgl	931	21	nsp15-endoU	nsp15-endoU	NNP
cord-259603-bh198xgl	931	22	)	)	-RRB-
cord-259603-bh198xgl	931	23	remain	remain	VBP
cord-259603-bh198xgl	931	24	to	to	TO
cord-259603-bh198xgl	931	25	be	be	VB
cord-259603-bh198xgl	931	26	found	find	VBN
cord-259603-bh198xgl	931	27	.	.	.
cord-259603-bh198xgl	932	1	As	as	IN
cord-259603-bh198xgl	932	2	highlighted	highlight	VBN
cord-259603-bh198xgl	932	3	by	by	IN
cord-259603-bh198xgl	932	4	several	several	JJ
cord-259603-bh198xgl	932	5	nsp	nsp	NN
cord-259603-bh198xgl	932	6	-	-	HYPH
cord-259603-bh198xgl	932	7	wide	wide	JJ
cord-259603-bh198xgl	932	8	interaction	interaction	NN
cord-259603-bh198xgl	932	9	screening	screening	NN
cord-259603-bh198xgl	932	10	studies	study	NNS
cord-259603-bh198xgl	932	11	Pan	Pan	NNP
cord-259603-bh198xgl	932	12	et	et	NNP
cord-259603-bh198xgl	932	13	al	al	NNP
cord-259603-bh198xgl	932	14	.	.	NNP
cord-259603-bh198xgl	932	15	,	,	,
cord-259603-bh198xgl	932	16	2008	2008	CD
cord-259603-bh198xgl	932	17	;	;	:
cord-259603-bh198xgl	932	18	von	von	NNP
cord-259603-bh198xgl	932	19	Brunn	Brunn	NNP
cord-259603-bh198xgl	932	20	et	et	NNP
cord-259603-bh198xgl	932	21	al	al	NNP
cord-259603-bh198xgl	932	22	.	.	NNP
cord-259603-bh198xgl	932	23	,	,	,
cord-259603-bh198xgl	932	24	2007	2007	CD
cord-259603-bh198xgl	932	25	)	)	-RRB-
cord-259603-bh198xgl	932	26	and	and	CC
cord-259603-bh198xgl	932	27	more	more	JJR
cord-259603-bh198xgl	932	28	specifically	specifically	RB
cord-259603-bh198xgl	932	29	by	by	IN
cord-259603-bh198xgl	932	30	the	the	DT
cord-259603-bh198xgl	932	31	in	in	FW
cord-259603-bh198xgl	932	32	vitro	vitro	FW
cord-259603-bh198xgl	932	33	data	datum	NNS
cord-259603-bh198xgl	932	34	on	on	IN
cord-259603-bh198xgl	932	35	the	the	DT
cord-259603-bh198xgl	932	36	interplay	interplay	NN
cord-259603-bh198xgl	932	37	between	between	IN
cord-259603-bh198xgl	932	38	nsp7	nsp7	JJ
cord-259603-bh198xgl	932	39	-	-	HYPH
cord-259603-bh198xgl	932	40	8	8	CD
cord-259603-bh198xgl	932	41	-	-	HYPH
cord-259603-bh198xgl	932	42	12	12	CD
cord-259603-bh198xgl	932	43	-	-	SYM
cord-259603-bh198xgl	932	44	14	14	CD
cord-259603-bh198xgl	932	45	(	(	-LRB-
cord-259603-bh198xgl	932	46	Subissi	Subissi	NNP
cord-259603-bh198xgl	932	47	et	et	NNP
cord-259603-bh198xgl	932	48	al	al	NNP
cord-259603-bh198xgl	932	49	.	.	NNP
cord-259603-bh198xgl	932	50	,	,	,
cord-259603-bh198xgl	932	51	2014b	2014b	CD
cord-259603-bh198xgl	932	52	)	)	-RRB-
cord-259603-bh198xgl	932	53	and	and	CC
cord-259603-bh198xgl	932	54	nsp10	nsp10	NNPS
cord-259603-bh198xgl	932	55	-	-	HYPH
cord-259603-bh198xgl	932	56	14	14	CD
cord-259603-bh198xgl	932	57	-	-	SYM
cord-259603-bh198xgl	932	58	16	16	CD
cord-259603-bh198xgl	932	59	(	(	-LRB-
cord-259603-bh198xgl	932	60	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	932	61	et	et	NNP
cord-259603-bh198xgl	932	62	al	al	NNP
cord-259603-bh198xgl	932	63	.	.	NNP
cord-259603-bh198xgl	932	64	,	,	,
cord-259603-bh198xgl	932	65	2014	2014	CD
cord-259603-bh198xgl	932	66	)	)	-RRB-
cord-259603-bh198xgl	932	67	,	,	,
cord-259603-bh198xgl	932	68	CoV	CoV	NNP
cord-259603-bh198xgl	932	69	nsps	nsps	NNP
cord-259603-bh198xgl	932	70	need	need	VBP
cord-259603-bh198xgl	932	71	to	to	TO
cord-259603-bh198xgl	932	72	work	work	VB
cord-259603-bh198xgl	932	73	together	together	RB
cord-259603-bh198xgl	932	74	in	in	IN
cord-259603-bh198xgl	932	75	many	many	JJ
cord-259603-bh198xgl	932	76	ways	way	NNS
cord-259603-bh198xgl	932	77	.	.	.
cord-259603-bh198xgl	933	1	The	the	DT
cord-259603-bh198xgl	933	2	further	further	JJ
cord-259603-bh198xgl	933	3	characterization	characterization	NN
cord-259603-bh198xgl	933	4	of	of	IN
cord-259603-bh198xgl	933	5	the	the	DT
cord-259603-bh198xgl	933	6	"	"	``
cord-259603-bh198xgl	933	7	nsp	nsp	NNP
cord-259603-bh198xgl	933	8	interactome	interactome	NNP
cord-259603-bh198xgl	933	9	,	,	,
cord-259603-bh198xgl	933	10	"	"	''
cord-259603-bh198xgl	933	11	now	now	RB
cord-259603-bh198xgl	933	12	also	also	RB
cord-259603-bh198xgl	933	13	inside	inside	IN
cord-259603-bh198xgl	933	14	the	the	DT
cord-259603-bh198xgl	933	15	CoV	cov	NN
cord-259603-bh198xgl	933	16	-	-	HYPH
cord-259603-bh198xgl	933	17	infected	infect	VBN
cord-259603-bh198xgl	933	18	cell	cell	NN
cord-259603-bh198xgl	933	19	,	,	,
cord-259603-bh198xgl	933	20	will	will	MD
cord-259603-bh198xgl	933	21	undoubtedly	undoubtedly	RB
cord-259603-bh198xgl	933	22	provide	provide	VB
cord-259603-bh198xgl	933	23	more	more	JJR
cord-259603-bh198xgl	933	24	clues	clue	NNS
cord-259603-bh198xgl	933	25	as	as	IN
cord-259603-bh198xgl	933	26	to	to	IN
cord-259603-bh198xgl	933	27	how	how	WRB
cord-259603-bh198xgl	933	28	specific	specific	JJ
cord-259603-bh198xgl	933	29	functions	function	NNS
cord-259603-bh198xgl	933	30	are	be	VBP
cord-259603-bh198xgl	933	31	switched	switch	VBN
cord-259603-bh198xgl	933	32	on	on	IN
cord-259603-bh198xgl	933	33	and	and	CC
cord-259603-bh198xgl	933	34	off	off	RB
cord-259603-bh198xgl	933	35	or	or	CC
cord-259603-bh198xgl	933	36	modulated	modulate	VBN
cord-259603-bh198xgl	933	37	.	.	.
cord-259603-bh198xgl	934	1	Likewise	likewise	RB
cord-259603-bh198xgl	934	2	,	,	,
cord-259603-bh198xgl	934	3	attention	attention	NN
cord-259603-bh198xgl	934	4	should	should	MD
cord-259603-bh198xgl	934	5	be	be	VB
cord-259603-bh198xgl	934	6	given	give	VBN
cord-259603-bh198xgl	934	7	to	to	IN
cord-259603-bh198xgl	934	8	defining	define	VBG
cord-259603-bh198xgl	934	9	the	the	DT
cord-259603-bh198xgl	934	10	interactions	interaction	NNS
cord-259603-bh198xgl	934	11	of	of	IN
cord-259603-bh198xgl	934	12	CoV	CoV	NNP
cord-259603-bh198xgl	934	13	nsps	nsps	NNP
cord-259603-bh198xgl	934	14	with	with	IN
cord-259603-bh198xgl	934	15	the	the	DT
cord-259603-bh198xgl	934	16	specific	specific	JJ
cord-259603-bh198xgl	934	17	RNA	RNA	NNP
cord-259603-bh198xgl	934	18	signals	signal	NNS
cord-259603-bh198xgl	934	19	for	for	IN
cord-259603-bh198xgl	934	20	genome	genome	NN
cord-259603-bh198xgl	934	21	replication	replication	NN
cord-259603-bh198xgl	934	22	(	(	-LRB-
cord-259603-bh198xgl	934	23	Madhugiri	Madhugiri	NNP
cord-259603-bh198xgl	934	24	et	et	NNP
cord-259603-bh198xgl	934	25	al	al	NNP
cord-259603-bh198xgl	934	26	.	.	NNP
cord-259603-bh198xgl	934	27	,	,	,
cord-259603-bh198xgl	934	28	2014	2014	CD
cord-259603-bh198xgl	934	29	;	;	:
cord-259603-bh198xgl	934	30	Yang	Yang	NNP
cord-259603-bh198xgl	934	31	and	and	CC
cord-259603-bh198xgl	934	32	Leibowitz	Leibowitz	NNP
cord-259603-bh198xgl	934	33	,	,	,
cord-259603-bh198xgl	934	34	2015	2015	CD
cord-259603-bh198xgl	934	35	)	)	-RRB-
cord-259603-bh198xgl	934	36	,	,	,
cord-259603-bh198xgl	934	37	discontinuous	discontinuous	JJ
cord-259603-bh198xgl	934	38	minus	minus	JJ
cord-259603-bh198xgl	934	39	-	-	HYPH
cord-259603-bh198xgl	934	40	strand	strand	NN
cord-259603-bh198xgl	934	41	RNA	RNA	NNP
cord-259603-bh198xgl	934	42	synthesis	synthesis	NN
cord-259603-bh198xgl	934	43	(	(	-LRB-
cord-259603-bh198xgl	934	44	attenuation	attenuation	NN
cord-259603-bh198xgl	934	45	at	at	IN
cord-259603-bh198xgl	934	46	body	body	NN
cord-259603-bh198xgl	934	47	TRSs	trs	NNS
cord-259603-bh198xgl	934	48	,	,	,
cord-259603-bh198xgl	934	49	nascent	nascent	JJ
cord-259603-bh198xgl	934	50	minus	minus	JJ
cord-259603-bh198xgl	934	51	-	-	HYPH
cord-259603-bh198xgl	934	52	strand	strand	NN
cord-259603-bh198xgl	934	53	transfer	transfer	NN
cord-259603-bh198xgl	934	54	,	,	,
cord-259603-bh198xgl	934	55	and	and	CC
cord-259603-bh198xgl	934	56	reinitiation	reinitiation	NN
cord-259603-bh198xgl	934	57	;	;	:
cord-259603-bh198xgl	934	58	Pasternak	Pasternak	NNP
cord-259603-bh198xgl	934	59	et	et	NNP
cord-259603-bh198xgl	934	60	al	al	NNP
cord-259603-bh198xgl	934	61	.	.	NNP
cord-259603-bh198xgl	934	62	,	,	,
cord-259603-bh198xgl	934	63	2006	2006	CD
cord-259603-bh198xgl	934	64	;	;	:
cord-259603-bh198xgl	934	65	Sawicki	Sawicki	NNP
cord-259603-bh198xgl	934	66	et	et	NNP
cord-259603-bh198xgl	934	67	al	al	NNP
cord-259603-bh198xgl	934	68	.	.	NNP
cord-259603-bh198xgl	934	69	,	,	,
cord-259603-bh198xgl	934	70	2007	2007	CD
cord-259603-bh198xgl	934	71	;	;	:
cord-259603-bh198xgl	934	72	Sola	Sola	NNP
cord-259603-bh198xgl	934	73	et	et	FW
cord-259603-bh198xgl	934	74	al	al	NNP
cord-259603-bh198xgl	934	75	.	.	NNP
cord-259603-bh198xgl	934	76	,	,	,
cord-259603-bh198xgl	934	77	2011	2011	CD
cord-259603-bh198xgl	934	78	)	)	-RRB-
cord-259603-bh198xgl	934	79	,	,	,
cord-259603-bh198xgl	934	80	and	and	CC
cord-259603-bh198xgl	934	81	the	the	DT
cord-259603-bh198xgl	934	82	transcription	transcription	NN
cord-259603-bh198xgl	934	83	,	,	,
cord-259603-bh198xgl	934	84	capping	capping	NN
cord-259603-bh198xgl	934	85	,	,	,
cord-259603-bh198xgl	934	86	and	and	CC
cord-259603-bh198xgl	934	87	polyadenylation	polyadenylation	NN
cord-259603-bh198xgl	934	88	of	of	IN
cord-259603-bh198xgl	934	89	sg	sg	NNP
cord-259603-bh198xgl	934	90	mRNAs	mRNAs	NNP
cord-259603-bh198xgl	935	1	(	(	-LRB-
cord-259603-bh198xgl	935	2	Fig	Fig	NNP
cord-259603-bh198xgl	935	3	.	.	NNP
cord-259603-bh198xgl	935	4	1	1	CD
cord-259603-bh198xgl	935	5	)	)	-RRB-
cord-259603-bh198xgl	935	6	.	.	.
cord-259603-bh198xgl	936	1	These	these	DT
cord-259603-bh198xgl	936	2	RNA	RNA	NNP
cord-259603-bh198xgl	936	3	sequences	sequence	NNS
cord-259603-bh198xgl	936	4	,	,	,
cord-259603-bh198xgl	936	5	several	several	JJ
cord-259603-bh198xgl	936	6	of	of	IN
cord-259603-bh198xgl	936	7	which	which	WDT
cord-259603-bh198xgl	936	8	may	may	MD
cord-259603-bh198xgl	936	9	be	be	VB
cord-259603-bh198xgl	936	10	cis	cis	NNP
cord-259603-bh198xgl	936	11	-	-	HYPH
cord-259603-bh198xgl	936	12	acting	acting	NN
cord-259603-bh198xgl	936	13	,	,	,
cord-259603-bh198xgl	936	14	could	could	MD
cord-259603-bh198xgl	936	15	provide	provide	VB
cord-259603-bh198xgl	936	16	starting	start	VBG
cord-259603-bh198xgl	936	17	points	point	NNS
cord-259603-bh198xgl	936	18	for	for	IN
cord-259603-bh198xgl	936	19	improved	improve	VBN
cord-259603-bh198xgl	936	20	biochemical	biochemical	JJ
cord-259603-bh198xgl	936	21	assays	assay	NNS
cord-259603-bh198xgl	936	22	,	,	,
cord-259603-bh198xgl	936	23	ultimately	ultimately	RB
cord-259603-bh198xgl	936	24	paving	pave	VBG
cord-259603-bh198xgl	936	25	the	the	DT
cord-259603-bh198xgl	936	26	way	way	NN
cord-259603-bh198xgl	936	27	for	for	IN
cord-259603-bh198xgl	936	28	the	the	DT
cord-259603-bh198xgl	936	29	complete	complete	JJ
cord-259603-bh198xgl	936	30	in	in	FW
cord-259603-bh198xgl	936	31	vitro	vitro	FW
cord-259603-bh198xgl	936	32	reconstitution	reconstitution	NN
cord-259603-bh198xgl	936	33	of	of	IN
cord-259603-bh198xgl	936	34	some	some	DT
cord-259603-bh198xgl	936	35	of	of	IN
cord-259603-bh198xgl	936	36	these	these	DT
cord-259603-bh198xgl	936	37	multi	multi	JJ
cord-259603-bh198xgl	936	38	-	-	JJ
cord-259603-bh198xgl	936	39	nsp	nsp	JJ
cord-259603-bh198xgl	936	40	-	-	HYPH
cord-259603-bh198xgl	936	41	driven	drive	VBN
cord-259603-bh198xgl	936	42	processes	process	NNS
cord-259603-bh198xgl	936	43	.	.	.
cord-259603-bh198xgl	937	1	The	the	DT
cord-259603-bh198xgl	937	2	analysis	analysis	NN
cord-259603-bh198xgl	937	3	of	of	IN
cord-259603-bh198xgl	937	4	CoV	cov	NN
cord-259603-bh198xgl	937	5	RTC	RTC	NNP
cord-259603-bh198xgl	937	6	structure	structure	NN
cord-259603-bh198xgl	937	7	and	and	CC
cord-259603-bh198xgl	937	8	function	function	NN
cord-259603-bh198xgl	937	9	in	in	IN
cord-259603-bh198xgl	937	10	the	the	DT
cord-259603-bh198xgl	937	11	living	live	VBG
cord-259603-bh198xgl	937	12	infected	infected	JJ
cord-259603-bh198xgl	937	13	cell	cell	NN
cord-259603-bh198xgl	937	14	remains	remain	VBZ
cord-259603-bh198xgl	937	15	an	an	DT
cord-259603-bh198xgl	937	16	enormous	enormous	JJ
cord-259603-bh198xgl	937	17	technical	technical	JJ
cord-259603-bh198xgl	937	18	challenge	challenge	NN
cord-259603-bh198xgl	937	19	,	,	,
cord-259603-bh198xgl	937	20	requiring	require	VBG
cord-259603-bh198xgl	937	21	continued	continue	VBN
cord-259603-bh198xgl	937	22	toolbox	toolbox	NN
cord-259603-bh198xgl	937	23	development	development	NN
cord-259603-bh198xgl	937	24	.	.	.
cord-259603-bh198xgl	938	1	It	-PRON-	PRP
cord-259603-bh198xgl	938	2	is	be	VBZ
cord-259603-bh198xgl	938	3	likely	likely	JJ
cord-259603-bh198xgl	938	4	that	that	IN
cord-259603-bh198xgl	938	5	several	several	JJ
cord-259603-bh198xgl	938	6	functional	functional	JJ
cord-259603-bh198xgl	938	7	riddles	riddle	NNS
cord-259603-bh198xgl	938	8	can	can	MD
cord-259603-bh198xgl	938	9	only	only	RB
cord-259603-bh198xgl	938	10	be	be	VB
cord-259603-bh198xgl	938	11	solved	solve	VBN
cord-259603-bh198xgl	938	12	by	by	IN
cord-259603-bh198xgl	938	13	studying	study	VBG
cord-259603-bh198xgl	938	14	infected	infected	JJ
cord-259603-bh198xgl	938	15	cells	cell	NNS
cord-259603-bh198xgl	938	16	.	.	.
cord-259603-bh198xgl	939	1	For	for	IN
cord-259603-bh198xgl	939	2	example	example	NN
cord-259603-bh198xgl	939	3	,	,	,
cord-259603-bh198xgl	939	4	the	the	DT
cord-259603-bh198xgl	939	5	endoribonuclease	endoribonuclease	NN
cord-259603-bh198xgl	939	6	activity	activity	NN
cord-259603-bh198xgl	939	7	of	of	IN
cord-259603-bh198xgl	939	8	the	the	DT
cord-259603-bh198xgl	939	9	nsp15	nsp15	NNP
cord-259603-bh198xgl	939	10	endoU	endoU	NNP
cord-259603-bh198xgl	939	11	domain	domain	NN
cord-259603-bh198xgl	939	12	,	,	,
cord-259603-bh198xgl	939	13	a	a	DT
cord-259603-bh198xgl	939	14	potential	potential	JJ
cord-259603-bh198xgl	939	15	"	"	``
cord-259603-bh198xgl	939	16	suicide	suicide	NN
cord-259603-bh198xgl	939	17	enzyme	enzyme	NN
cord-259603-bh198xgl	939	18	"	"	''
cord-259603-bh198xgl	939	19	for	for	IN
cord-259603-bh198xgl	939	20	an	an	DT
cord-259603-bh198xgl	939	21	RNA	RNA	NNP
cord-259603-bh198xgl	939	22	virus	virus	NN
cord-259603-bh198xgl	939	23	,	,	,
cord-259603-bh198xgl	939	24	must	must	MD
cord-259603-bh198xgl	939	25	be	be	VB
cord-259603-bh198xgl	939	26	controlled	control	VBN
cord-259603-bh198xgl	939	27	tightly	tightly	RB
cord-259603-bh198xgl	939	28	in	in	IN
cord-259603-bh198xgl	939	29	the	the	DT
cord-259603-bh198xgl	939	30	infected	infected	JJ
cord-259603-bh198xgl	939	31	cell	cell	NN
cord-259603-bh198xgl	939	32	.	.	.
cord-259603-bh198xgl	940	1	Whereas	whereas	IN
cord-259603-bh198xgl	940	2	the	the	DT
cord-259603-bh198xgl	940	3	enzyme	enzyme	NN
cord-259603-bh198xgl	940	4	is	be	VBZ
cord-259603-bh198xgl	940	5	highly	highly	RB
cord-259603-bh198xgl	940	6	active	active	JJ
cord-259603-bh198xgl	940	7	and	and	CC
cord-259603-bh198xgl	940	8	displays	display	VBZ
cord-259603-bh198xgl	940	9	only	only	RB
cord-259603-bh198xgl	940	10	very	very	RB
cord-259603-bh198xgl	940	11	limited	limited	JJ
cord-259603-bh198xgl	940	12	substrate	substrate	NN
cord-259603-bh198xgl	940	13	specificity	specificity	NN
cord-259603-bh198xgl	940	14	in	in	IN
cord-259603-bh198xgl	940	15	vitro	vitro	FW
cord-259603-bh198xgl	940	16	(	(	-LRB-
cord-259603-bh198xgl	941	1	Ivanov	Ivanov	NNP
cord-259603-bh198xgl	941	2	et	et	NNP
cord-259603-bh198xgl	941	3	al	al	NNP
cord-259603-bh198xgl	941	4	.	.	NNP
cord-259603-bh198xgl	941	5	,	,	,
cord-259603-bh198xgl	941	6	2004a	2004a	CD
cord-259603-bh198xgl	941	7	;	;	:
cord-259603-bh198xgl	941	8	Nedialkova	Nedialkova	NNP
cord-259603-bh198xgl	941	9	et	et	NNP
cord-259603-bh198xgl	941	10	al	al	NNP
cord-259603-bh198xgl	941	11	.	.	NNP
cord-259603-bh198xgl	941	12	,	,	,
cord-259603-bh198xgl	941	13	2009	2009	CD
cord-259603-bh198xgl	941	14	)	)	-RRB-
cord-259603-bh198xgl	941	15	,	,	,
cord-259603-bh198xgl	941	16	it	-PRON-	PRP
cord-259603-bh198xgl	941	17	may	may	MD
cord-259603-bh198xgl	941	18	be	be	VB
cord-259603-bh198xgl	941	19	confined	confine	VBN
cord-259603-bh198xgl	941	20	to	to	IN
cord-259603-bh198xgl	941	21	a	a	DT
cord-259603-bh198xgl	941	22	specific	specific	JJ
cord-259603-bh198xgl	941	23	compartment	compartment	NN
cord-259603-bh198xgl	941	24	in	in	IN
cord-259603-bh198xgl	941	25	the	the	DT
cord-259603-bh198xgl	941	26	infected	infected	JJ
cord-259603-bh198xgl	941	27	cell	cell	NN
cord-259603-bh198xgl	941	28	and/or	and/or	CC
cord-259603-bh198xgl	941	29	its	-PRON-	PRP$
cord-259603-bh198xgl	941	30	activity	activity	NN
cord-259603-bh198xgl	941	31	may	may	MD
cord-259603-bh198xgl	941	32	be	be	VB
cord-259603-bh198xgl	941	33	modulated	modulate	VBN
cord-259603-bh198xgl	941	34	by	by	IN
cord-259603-bh198xgl	941	35	interactions	interaction	NNS
cord-259603-bh198xgl	941	36	with	with	IN
cord-259603-bh198xgl	941	37	other	other	JJ
cord-259603-bh198xgl	941	38	nsps	nsp	NNS
cord-259603-bh198xgl	941	39	or	or	CC
cord-259603-bh198xgl	941	40	host	host	NN
cord-259603-bh198xgl	941	41	factors	factor	NNS
cord-259603-bh198xgl	941	42	.	.	.
cord-259603-bh198xgl	942	1	Such	such	JJ
cord-259603-bh198xgl	942	2	differences	difference	NNS
cord-259603-bh198xgl	942	3	between	between	IN
cord-259603-bh198xgl	942	4	in	in	IN
cord-259603-bh198xgl	942	5	vitro	vitro	FW
cord-259603-bh198xgl	942	6	and	and	CC
cord-259603-bh198xgl	942	7	in	in	IN
cord-259603-bh198xgl	942	8	vivo	vivo	NN
cord-259603-bh198xgl	942	9	activities	activity	NNS
cord-259603-bh198xgl	942	10	will	will	MD
cord-259603-bh198xgl	942	11	surely	surely	RB
cord-259603-bh198xgl	942	12	emerge	emerge	VB
cord-259603-bh198xgl	942	13	for	for	IN
cord-259603-bh198xgl	942	14	other	other	JJ
cord-259603-bh198xgl	942	15	nsps	nsp	NNS
cord-259603-bh198xgl	942	16	as	as	RB
cord-259603-bh198xgl	942	17	well	well	RB
cord-259603-bh198xgl	942	18	,	,	,
cord-259603-bh198xgl	942	19	and	and	CC
cord-259603-bh198xgl	942	20	they	-PRON-	PRP
cord-259603-bh198xgl	942	21	may	may	MD
cord-259603-bh198xgl	942	22	be	be	VB
cord-259603-bh198xgl	942	23	better	well	RBR
cord-259603-bh198xgl	942	24	understood	understand	VBN
cord-259603-bh198xgl	942	25	following	follow	VBG
cord-259603-bh198xgl	942	26	the	the	DT
cord-259603-bh198xgl	942	27	further	further	JJ
cord-259603-bh198xgl	942	28	characterization	characterization	NN
cord-259603-bh198xgl	942	29	(	(	-LRB-
cord-259603-bh198xgl	942	30	including	include	VBG
cord-259603-bh198xgl	942	31	their	-PRON-	PRP$
cord-259603-bh198xgl	942	32	lipid	lipid	NN
cord-259603-bh198xgl	942	33	composition	composition	NN
cord-259603-bh198xgl	942	34	)	)	-RRB-
cord-259603-bh198xgl	942	35	of	of	IN
cord-259603-bh198xgl	942	36	the	the	DT
cord-259603-bh198xgl	942	37	membranous	membranous	JJ
cord-259603-bh198xgl	942	38	replication	replication	NN
cord-259603-bh198xgl	942	39	organelles	organelle	NNS
cord-259603-bh198xgl	942	40	with	with	IN
cord-259603-bh198xgl	942	41	which	which	WDT
cord-259603-bh198xgl	942	42	the	the	DT
cord-259603-bh198xgl	942	43	metabolically	metabolically	RB
cord-259603-bh198xgl	942	44	active	active	JJ
cord-259603-bh198xgl	942	45	CoV	cov	NN
cord-259603-bh198xgl	942	46	RTC	RTC	NNP
cord-259603-bh198xgl	942	47	presumably	presumably	RB
cord-259603-bh198xgl	942	48	is	be	VBZ
cord-259603-bh198xgl	942	49	associated	associate	VBN
cord-259603-bh198xgl	943	1	(	(	-LRB-
cord-259603-bh198xgl	943	2	Hagemeijer	Hagemeijer	NNP
cord-259603-bh198xgl	943	3	et	et	NNP
cord-259603-bh198xgl	943	4	al	al	NNP
cord-259603-bh198xgl	943	5	.	.	NNP
cord-259603-bh198xgl	943	6	,	,	,
cord-259603-bh198xgl	943	7	2012	2012	CD
cord-259603-bh198xgl	943	8	;	;	:
cord-259603-bh198xgl	943	9	Neuman	Neuman	NNP
cord-259603-bh198xgl	943	10	et	et	NNP
cord-259603-bh198xgl	943	11	al	al	NNP
cord-259603-bh198xgl	943	12	.	.	NNP
cord-259603-bh198xgl	943	13	,	,	,
cord-259603-bh198xgl	943	14	2014a	2014a	CD
cord-259603-bh198xgl	943	15	;	;	:
cord-259603-bh198xgl	943	16	van	van	NNP
cord-259603-bh198xgl	943	17	der	der	NNP
cord-259603-bh198xgl	943	18	Hoeven	Hoeven	NNP
cord-259603-bh198xgl	943	19	et	et	NNP
cord-259603-bh198xgl	943	20	al	al	NNP
cord-259603-bh198xgl	943	21	.	.	NNP
cord-259603-bh198xgl	943	22	,	,	,
cord-259603-bh198xgl	943	23	2016	2016	CD
cord-259603-bh198xgl	943	24	)	)	-RRB-
cord-259603-bh198xgl	943	25	.	.	.
cord-259603-bh198xgl	944	1	These	these	DT
cord-259603-bh198xgl	944	2	studies	study	NNS
cord-259603-bh198xgl	944	3	should	should	MD
cord-259603-bh198xgl	944	4	also	also	RB
cord-259603-bh198xgl	944	5	answer	answer	VB
cord-259603-bh198xgl	944	6	the	the	DT
cord-259603-bh198xgl	944	7	question	question	NN
cord-259603-bh198xgl	944	8	of	of	IN
cord-259603-bh198xgl	944	9	how	how	WRB
cord-259603-bh198xgl	944	10	both	both	CC
cord-259603-bh198xgl	944	11	nsps	nsp	NNS
cord-259603-bh198xgl	944	12	and	and	CC
cord-259603-bh198xgl	944	13	viral	viral	JJ
cord-259603-bh198xgl	944	14	RNA	RNA	NNP
cord-259603-bh198xgl	944	15	substrates	substrate	NNS
cord-259603-bh198xgl	944	16	are	be	VBP
cord-259603-bh198xgl	944	17	targeted	target	VBN
cord-259603-bh198xgl	944	18	to	to	IN
cord-259603-bh198xgl	944	19	or	or	CC
cord-259603-bh198xgl	944	20	recruited	recruit	VBN
cord-259603-bh198xgl	944	21	by	by	IN
cord-259603-bh198xgl	944	22	the	the	DT
cord-259603-bh198xgl	944	23	membrane	membrane	NN
cord-259603-bh198xgl	944	24	-	-	HYPH
cord-259603-bh198xgl	944	25	bound	bind	VBN
cord-259603-bh198xgl	944	26	CoV	cov	NN
cord-259603-bh198xgl	944	27	RTC	RTC	NNP
cord-259603-bh198xgl	944	28	,	,	,
cord-259603-bh198xgl	944	29	in	in	IN
cord-259603-bh198xgl	944	30	particular	particular	JJ
cord-259603-bh198xgl	944	31	also	also	RB
cord-259603-bh198xgl	944	32	during	during	IN
cord-259603-bh198xgl	944	33	the	the	DT
cord-259603-bh198xgl	944	34	earlier	early	JJR
cord-259603-bh198xgl	944	35	stages	stage	NNS
cord-259603-bh198xgl	944	36	of	of	IN
cord-259603-bh198xgl	944	37	infection	infection	NN
cord-259603-bh198xgl	944	38	when	when	WRB
cord-259603-bh198xgl	944	39	viral	viral	JJ
cord-259603-bh198xgl	944	40	RNA	RNA	NNP
cord-259603-bh198xgl	944	41	synthesis	synthesis	NN
cord-259603-bh198xgl	944	42	appears	appear	VBZ
cord-259603-bh198xgl	944	43	to	to	TO
cord-259603-bh198xgl	944	44	be	be	VB
cord-259603-bh198xgl	944	45	taking	take	VBG
cord-259603-bh198xgl	944	46	off	off	RP
cord-259603-bh198xgl	944	47	in	in	IN
cord-259603-bh198xgl	944	48	the	the	DT
cord-259603-bh198xgl	944	49	absence	absence	NN
cord-259603-bh198xgl	944	50	of	of	IN
cord-259603-bh198xgl	944	51	the	the	DT
cord-259603-bh198xgl	944	52	prominent	prominent	JJ
cord-259603-bh198xgl	944	53	membrane	membrane	NN
cord-259603-bh198xgl	944	54	rearrangements	rearrangement	NNS
cord-259603-bh198xgl	944	55	observed	observe	VBD
cord-259603-bh198xgl	944	56	later	later	RB
cord-259603-bh198xgl	944	57	in	in	IN
cord-259603-bh198xgl	944	58	infection	infection	NN
cord-259603-bh198xgl	944	59	.	.	.
cord-259603-bh198xgl	945	1	Specific	specific	JJ
cord-259603-bh198xgl	945	2	mutations	mutation	NNS
cord-259603-bh198xgl	945	3	in	in	IN
cord-259603-bh198xgl	945	4	CoV	cov	NN
cord-259603-bh198xgl	945	5	genomes	genome	NNS
cord-259603-bh198xgl	945	6	can	can	MD
cord-259603-bh198xgl	945	7	now	now	RB
cord-259603-bh198xgl	945	8	be	be	VB
cord-259603-bh198xgl	945	9	reverse	reverse	RB
cord-259603-bh198xgl	945	10	engineered	engineer	VBN
cord-259603-bh198xgl	945	11	,	,	,
cord-259603-bh198xgl	945	12	but	but	CC
cord-259603-bh198xgl	945	13	many	many	JJ
cord-259603-bh198xgl	945	14	of	of	IN
cord-259603-bh198xgl	945	15	the	the	DT
cord-259603-bh198xgl	945	16	functions	function	NNS
cord-259603-bh198xgl	945	17	encoded	encode	VBN
cord-259603-bh198xgl	945	18	by	by	IN
cord-259603-bh198xgl	945	19	nsp7-nsp12	nsp7-nsp12	NNS
cord-259603-bh198xgl	945	20	are	be	VBP
cord-259603-bh198xgl	945	21	so	so	RB
cord-259603-bh198xgl	945	22	basic	basic	JJ
cord-259603-bh198xgl	945	23	that	that	IN
cord-259603-bh198xgl	945	24	their	-PRON-	PRP$
cord-259603-bh198xgl	945	25	inactivation	inactivation	NN
cord-259603-bh198xgl	945	26	will	will	MD
cord-259603-bh198xgl	945	27	merely	merely	RB
cord-259603-bh198xgl	945	28	result	result	VB
cord-259603-bh198xgl	945	29	in	in	IN
cord-259603-bh198xgl	945	30	dead	dead	JJ
cord-259603-bh198xgl	945	31	virus	virus	NN
cord-259603-bh198xgl	945	32	mutants	mutant	NNS
cord-259603-bh198xgl	945	33	that	that	WDT
cord-259603-bh198xgl	945	34	do	do	VBP
cord-259603-bh198xgl	945	35	not	not	RB
cord-259603-bh198xgl	945	36	provide	provide	VB
cord-259603-bh198xgl	945	37	many	many	JJ
cord-259603-bh198xgl	945	38	deeper	deep	JJR
cord-259603-bh198xgl	945	39	insights	insight	NNS
cord-259603-bh198xgl	945	40	into	into	IN
cord-259603-bh198xgl	945	41	nsp	nsp	NN
cord-259603-bh198xgl	945	42	function	function	NN
cord-259603-bh198xgl	945	43	.	.	.
cord-259603-bh198xgl	946	1	This	this	DT
cord-259603-bh198xgl	946	2	in	in	IN
cord-259603-bh198xgl	946	3	part	part	NN
cord-259603-bh198xgl	946	4	explains	explain	VBZ
cord-259603-bh198xgl	946	5	why	why	WRB
cord-259603-bh198xgl	946	6	most	most	JJS
cord-259603-bh198xgl	946	7	progress	progress	NN
cord-259603-bh198xgl	946	8	thus	thus	RB
cord-259603-bh198xgl	946	9	far	far	RB
cord-259603-bh198xgl	946	10	has	have	VBZ
cord-259603-bh198xgl	946	11	been	be	VBN
cord-259603-bh198xgl	946	12	made	make	VBN
cord-259603-bh198xgl	946	13	for	for	IN
cord-259603-bh198xgl	946	14	some	some	DT
cord-259603-bh198xgl	946	15	of	of	IN
cord-259603-bh198xgl	946	16	the	the	DT
cord-259603-bh198xgl	946	17	functions	function	NNS
cord-259603-bh198xgl	946	18	that	that	WDT
cord-259603-bh198xgl	946	19	can	can	MD
cord-259603-bh198xgl	946	20	-	-	HYPH
cord-259603-bh198xgl	946	21	fortunatelybe	fortunatelybe	NNP
cord-259603-bh198xgl	946	22	inactivated	inactivate	VBN
cord-259603-bh198xgl	946	23	without	without	IN
cord-259603-bh198xgl	946	24	such	such	JJ
cord-259603-bh198xgl	946	25	lethal	lethal	JJ
cord-259603-bh198xgl	946	26	consequences	consequence	NNS
cord-259603-bh198xgl	946	27	,	,	,
cord-259603-bh198xgl	946	28	like	like	IN
cord-259603-bh198xgl	946	29	the	the	DT
cord-259603-bh198xgl	946	30	nsp14	nsp14	NNP
cord-259603-bh198xgl	946	31	ExoN	ExoN	NNP
cord-259603-bh198xgl	946	32	and	and	CC
cord-259603-bh198xgl	946	33	nsp16	nsp16	NNS
cord-259603-bh198xgl	947	1	2	2	LS
cord-259603-bh198xgl	947	2	0	0	CD
cord-259603-bh198xgl	947	3	-O	-o	CD
cord-259603-bh198xgl	947	4	-	-	HYPH
cord-259603-bh198xgl	947	5	MTase	mtase	JJ
cord-259603-bh198xgl	947	6	enzymes	enzyme	NNS
cord-259603-bh198xgl	947	7	(	(	-LRB-
cord-259603-bh198xgl	948	1	Eckerle	Eckerle	NNP
cord-259603-bh198xgl	948	2	et	et	NNP
cord-259603-bh198xgl	948	3	al	al	NNP
cord-259603-bh198xgl	948	4	.	.	.
cord-259603-bh198xgl	949	1	,	,	,
cord-259603-bh198xgl	949	2	2007	2007	CD
cord-259603-bh198xgl	950	1	(	(	-LRB-
cord-259603-bh198xgl	950	2	Eckerle	Eckerle	NNP
cord-259603-bh198xgl	950	3	et	et	NNP
cord-259603-bh198xgl	950	4	al	al	NNP
cord-259603-bh198xgl	950	5	.	.	.
cord-259603-bh198xgl	951	1	,	,	,
cord-259603-bh198xgl	951	2	,	,	,
cord-259603-bh198xgl	951	3	2010	2010	CD
cord-259603-bh198xgl	951	4	Graham	Graham	NNP
cord-259603-bh198xgl	951	5	et	et	NNP
cord-259603-bh198xgl	951	6	al	al	NNP
cord-259603-bh198xgl	951	7	.	.	NNP
cord-259603-bh198xgl	951	8	,	,	,
cord-259603-bh198xgl	951	9	2012	2012	CD
cord-259603-bh198xgl	951	10	;	;	.
cord-259603-bh198xgl	952	1	Menachery	Menachery	NNP
cord-259603-bh198xgl	952	2	et	et	NNP
cord-259603-bh198xgl	952	3	al	al	NNP
cord-259603-bh198xgl	952	4	.	.	.
cord-259603-bh198xgl	953	1	,	,	,
cord-259603-bh198xgl	953	2	2014	2014	CD
cord-259603-bh198xgl	953	3	;	;	:
cord-259603-bh198xgl	953	4	Smith	Smith	NNP
cord-259603-bh198xgl	953	5	et	et	NNP
cord-259603-bh198xgl	953	6	al	al	NNP
cord-259603-bh198xgl	953	7	.	.	.
cord-259603-bh198xgl	954	1	,	,	,
cord-259603-bh198xgl	954	2	2013	2013	CD
cord-259603-bh198xgl	954	3	;	;	:
cord-259603-bh198xgl	954	4	Z€	Z€	NNP
cord-259603-bh198xgl	954	5	ust	ust	NNP
cord-259603-bh198xgl	954	6	et	et	NNP
cord-259603-bh198xgl	954	7	al	al	NNP
cord-259603-bh198xgl	954	8	.	.	NNP
cord-259603-bh198xgl	954	9	,	,	,
cord-259603-bh198xgl	954	10	2011	2011	CD
cord-259603-bh198xgl	954	11	)	)	-RRB-
cord-259603-bh198xgl	954	12	.	.	.
cord-259603-bh198xgl	955	1	For	for	IN
cord-259603-bh198xgl	955	2	this	this	DT
cord-259603-bh198xgl	955	3	reason	reason	NN
cord-259603-bh198xgl	955	4	,	,	,
cord-259603-bh198xgl	955	5	the	the	DT
cord-259603-bh198xgl	955	6	field	field	NN
cord-259603-bh198xgl	955	7	should	should	MD
cord-259603-bh198xgl	955	8	continue	continue	VB
cord-259603-bh198xgl	955	9	to	to	TO
cord-259603-bh198xgl	955	10	also	also	RB
cord-259603-bh198xgl	955	11	employ	employ	VB
cord-259603-bh198xgl	955	12	"	"	``
cord-259603-bh198xgl	955	13	traditional	traditional	JJ
cord-259603-bh198xgl	955	14	"	"	''
cord-259603-bh198xgl	955	15	(	(	-LRB-
cord-259603-bh198xgl	955	16	forward	forward	RB
cord-259603-bh198xgl	955	17	)	)	-RRB-
cord-259603-bh198xgl	955	18	genetic	genetic	JJ
cord-259603-bh198xgl	955	19	methods	method	NNS
cord-259603-bh198xgl	955	20	to	to	TO
cord-259603-bh198xgl	955	21	characterize	characterize	VB
cord-259603-bh198xgl	955	22	(	(	-LRB-
cord-259603-bh198xgl	955	23	and	and	CC
cord-259603-bh198xgl	955	24	produce	produce	VB
cord-259603-bh198xgl	955	25	more	more	JJR
cord-259603-bh198xgl	955	26	)	)	-RRB-
cord-259603-bh198xgl	955	27	conditionally	conditionally	RB
cord-259603-bh198xgl	955	28	defective	defective	JJ
cord-259603-bh198xgl	955	29	CoVs	CoVs	NNP
cord-259603-bh198xgl	955	30	,	,	,
cord-259603-bh198xgl	955	31	like	like	IN
cord-259603-bh198xgl	955	32	temperature	temperature	NN
cord-259603-bh198xgl	955	33	-	-	HYPH
cord-259603-bh198xgl	955	34	sensitive	sensitive	JJ
cord-259603-bh198xgl	955	35	mutants	mutant	NNS
cord-259603-bh198xgl	956	1	(	(	-LRB-
cord-259603-bh198xgl	956	2	Sawicki	Sawicki	NNP
cord-259603-bh198xgl	956	3	et	et	NNP
cord-259603-bh198xgl	956	4	al	al	NNP
cord-259603-bh198xgl	956	5	.	.	NNP
cord-259603-bh198xgl	956	6	,	,	,
cord-259603-bh198xgl	956	7	2005	2005	CD
cord-259603-bh198xgl	956	8	)	)	-RRB-
cord-259603-bh198xgl	956	9	.	.	.
cord-259603-bh198xgl	957	1	Thanks	thank	NNS
cord-259603-bh198xgl	957	2	to	to	IN
cord-259603-bh198xgl	957	3	the	the	DT
cord-259603-bh198xgl	957	4	advent	advent	NN
cord-259603-bh198xgl	957	5	of	of	IN
cord-259603-bh198xgl	957	6	next	next	JJ
cord-259603-bh198xgl	957	7	-	-	HYPH
cord-259603-bh198xgl	957	8	generation	generation	NN
cord-259603-bh198xgl	957	9	sequencing	sequencing	NN
cord-259603-bh198xgl	957	10	technologies	technology	NNS
cord-259603-bh198xgl	957	11	,	,	,
cord-259603-bh198xgl	957	12	tracing	trace	VBG
cord-259603-bh198xgl	957	13	the	the	DT
cord-259603-bh198xgl	957	14	evolution	evolution	NN
cord-259603-bh198xgl	957	15	of	of	IN
cord-259603-bh198xgl	957	16	crippled	crippled	JJ
cord-259603-bh198xgl	957	17	virus	virus	NN
cord-259603-bh198xgl	957	18	mutants	mutant	NNS
cord-259603-bh198xgl	957	19	and	and	CC
cord-259603-bh198xgl	957	20	(	(	-LRB-
cord-259603-bh198xgl	957	21	pseudo	pseudo	JJ
cord-259603-bh198xgl	957	22	)	)	-RRB-
cord-259603-bh198xgl	957	23	revertants	revertant	NNS
cord-259603-bh198xgl	957	24	has	have	VBZ
cord-259603-bh198xgl	957	25	become	become	VBN
cord-259603-bh198xgl	957	26	much	much	RB
cord-259603-bh198xgl	957	27	more	more	RBR
cord-259603-bh198xgl	957	28	straightforward	straightforward	JJ
cord-259603-bh198xgl	957	29	than	than	IN
cord-259603-bh198xgl	957	30	before	before	RB
cord-259603-bh198xgl	957	31	,	,	,
cord-259603-bh198xgl	957	32	and	and	CC
cord-259603-bh198xgl	957	33	this	this	DT
cord-259603-bh198xgl	957	34	approach	approach	NN
cord-259603-bh198xgl	957	35	(	(	-LRB-
cord-259603-bh198xgl	957	36	letting	let	VBG
cord-259603-bh198xgl	957	37	the	the	DT
cord-259603-bh198xgl	957	38	virus	virus	NN
cord-259603-bh198xgl	957	39	do	do	VB
cord-259603-bh198xgl	957	40	the	the	DT
cord-259603-bh198xgl	957	41	work	work	NN
cord-259603-bh198xgl	957	42	)	)	-RRB-
cord-259603-bh198xgl	957	43	likely	likely	RB
cord-259603-bh198xgl	957	44	is	be	VBZ
cord-259603-bh198xgl	957	45	among	among	IN
cord-259603-bh198xgl	957	46	the	the	DT
cord-259603-bh198xgl	957	47	most	most	RBS
cord-259603-bh198xgl	957	48	economical	economical	JJ
cord-259603-bh198xgl	957	49	ones	one	NNS
cord-259603-bh198xgl	957	50	in	in	IN
cord-259603-bh198xgl	957	51	uncovering	uncover	VBG
cord-259603-bh198xgl	957	52	previously	previously	RB
cord-259603-bh198xgl	957	53	unknown	unknown	JJ
cord-259603-bh198xgl	957	54	interactions	interaction	NNS
cord-259603-bh198xgl	957	55	between	between	IN
cord-259603-bh198xgl	957	56	the	the	DT
cord-259603-bh198xgl	957	57	protein	protein	NN
cord-259603-bh198xgl	957	58	and	and	CC
cord-259603-bh198xgl	957	59	RNA	RNA	NNP
cord-259603-bh198xgl	957	60	players	player	NNS
cord-259603-bh198xgl	957	61	in	in	IN
cord-259603-bh198xgl	957	62	CoV	cov	NN
cord-259603-bh198xgl	957	63	replication	replication	NN
cord-259603-bh198xgl	957	64	(	(	-LRB-
cord-259603-bh198xgl	958	1	Z€	Z€	NNP
cord-259603-bh198xgl	958	2	ust	ust	NNP
cord-259603-bh198xgl	958	3	et	et	NNP
cord-259603-bh198xgl	958	4	al	al	NNP
cord-259603-bh198xgl	958	5	.	.	.
cord-259603-bh198xgl	959	1	,	,	,
cord-259603-bh198xgl	959	2	2008	2008	CD
cord-259603-bh198xgl	959	3	)	)	-RRB-
cord-259603-bh198xgl	959	4	.	.	.
cord-259603-bh198xgl	960	1	Furthermore	furthermore	RB
cord-259603-bh198xgl	960	2	,	,	,
cord-259603-bh198xgl	960	3	it	-PRON-	PRP
cord-259603-bh198xgl	960	4	may	may	MD
cord-259603-bh198xgl	960	5	be	be	VB
cord-259603-bh198xgl	960	6	possible	possible	JJ
cord-259603-bh198xgl	960	7	to	to	TO
cord-259603-bh198xgl	960	8	develop	develop	VB
cord-259603-bh198xgl	960	9	cell	cell	NN
cord-259603-bh198xgl	960	10	-	-	HYPH
cord-259603-bh198xgl	960	11	based	base	VBN
cord-259603-bh198xgl	960	12	assays	assay	NNS
cord-259603-bh198xgl	960	13	for	for	IN
cord-259603-bh198xgl	960	14	the	the	DT
cord-259603-bh198xgl	960	15	analysis	analysis	NN
cord-259603-bh198xgl	960	16	of	of	IN
cord-259603-bh198xgl	960	17	CoV	CoV	NNP
cord-259603-bh198xgl	960	18	nsp	nsp	NNP
cord-259603-bh198xgl	960	19	functions	function	NNS
cord-259603-bh198xgl	960	20	that	that	WDT
cord-259603-bh198xgl	960	21	do	do	VBP
cord-259603-bh198xgl	960	22	not	not	RB
cord-259603-bh198xgl	960	23	rely	rely	VB
cord-259603-bh198xgl	960	24	on	on	IN
cord-259603-bh198xgl	960	25	having	have	VBG
cord-259603-bh198xgl	960	26	a	a	DT
cord-259603-bh198xgl	960	27	replication	replication	NN
cord-259603-bh198xgl	960	28	-	-	HYPH
cord-259603-bh198xgl	960	29	competent	competent	JJ
cord-259603-bh198xgl	960	30	virus	virus	NN
cord-259603-bh198xgl	960	31	to	to	TO
cord-259603-bh198xgl	960	32	start	start	VB
cord-259603-bh198xgl	960	33	with	with	IN
cord-259603-bh198xgl	960	34	.	.	.
cord-259603-bh198xgl	961	1	Unraveling	unravel	VBG
cord-259603-bh198xgl	961	2	the	the	DT
cord-259603-bh198xgl	961	3	molecular	molecular	JJ
cord-259603-bh198xgl	961	4	mechanisms	mechanism	NNS
cord-259603-bh198xgl	961	5	underlying	underlie	VBG
cord-259603-bh198xgl	961	6	the	the	DT
cord-259603-bh198xgl	961	7	presumed	presume	VBN
cord-259603-bh198xgl	961	8	mismatch	mismatch	NN
cord-259603-bh198xgl	961	9	excision	excision	NN
cord-259603-bh198xgl	961	10	function	function	NN
cord-259603-bh198xgl	961	11	(	(	-LRB-
cord-259603-bh198xgl	961	12	Bouvet	Bouvet	NNP
cord-259603-bh198xgl	961	13	et	et	NNP
cord-259603-bh198xgl	961	14	al	al	NNP
cord-259603-bh198xgl	961	15	.	.	NNP
cord-259603-bh198xgl	961	16	,	,	,
cord-259603-bh198xgl	961	17	2012	2012	CD
cord-259603-bh198xgl	961	18	)	)	-RRB-
cord-259603-bh198xgl	961	19	of	of	IN
cord-259603-bh198xgl	961	20	the	the	DT
cord-259603-bh198xgl	961	21	nsp14-ExoN	nsp14-ExoN	NNP
cord-259603-bh198xgl	961	22	,	,	,
cord-259603-bh198xgl	961	23	which	which	WDT
cord-259603-bh198xgl	961	24	is	be	VBZ
cord-259603-bh198xgl	961	25	uniquely	uniquely	RB
cord-259603-bh198xgl	961	26	encoded	encode	VBN
cord-259603-bh198xgl	961	27	by	by	IN
cord-259603-bh198xgl	961	28	RNA	RNA	NNP
cord-259603-bh198xgl	961	29	virus	virus	NN
cord-259603-bh198xgl	961	30	genomes	genome	NNS
cord-259603-bh198xgl	961	31	larger	large	JJR
cord-259603-bh198xgl	961	32	than	than	IN
cord-259603-bh198xgl	961	33	20	20	CD
cord-259603-bh198xgl	961	34	kb	kb	NNS
cord-259603-bh198xgl	962	1	(	(	-LRB-
cord-259603-bh198xgl	962	2	Nga	Nga	NNP
cord-259603-bh198xgl	962	3	et	et	NNP
cord-259603-bh198xgl	962	4	al	al	NNP
cord-259603-bh198xgl	962	5	.	.	.
cord-259603-bh198xgl	963	1	,	,	,
cord-259603-bh198xgl	963	2	2011	2011	CD
cord-259603-bh198xgl	963	3	)	)	-RRB-
cord-259603-bh198xgl	963	4	,	,	,
cord-259603-bh198xgl	963	5	connects	connect	VBZ
cord-259603-bh198xgl	963	6	to	to	IN
cord-259603-bh198xgl	963	7	the	the	DT
cord-259603-bh198xgl	963	8	mechanisms	mechanism	NNS
cord-259603-bh198xgl	963	9	driving	drive	VBG
cord-259603-bh198xgl	963	10	the	the	DT
cord-259603-bh198xgl	963	11	evolution	evolution	NN
cord-259603-bh198xgl	963	12	of	of	IN
cord-259603-bh198xgl	963	13	nidoviruses	nidoviruse	NNS
cord-259603-bh198xgl	963	14	at	at	IN
cord-259603-bh198xgl	963	15	large	large	JJ
cord-259603-bh198xgl	963	16	(	(	-LRB-
cord-259603-bh198xgl	963	17	Lauber	Lauber	NNP
cord-259603-bh198xgl	963	18	et	et	FW
cord-259603-bh198xgl	963	19	al	al	NNP
cord-259603-bh198xgl	963	20	.	.	NNP
cord-259603-bh198xgl	963	21	,	,	,
cord-259603-bh198xgl	963	22	2013	2013	CD
cord-259603-bh198xgl	963	23	)	)	-RRB-
cord-259603-bh198xgl	963	24	.	.	.
cord-259603-bh198xgl	964	1	Also	also	RB
cord-259603-bh198xgl	964	2	,	,	,
cord-259603-bh198xgl	964	3	replicases	replicase	NNS
cord-259603-bh198xgl	964	4	from	from	IN
cord-259603-bh198xgl	964	5	other	other	JJ
cord-259603-bh198xgl	964	6	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	964	7	branches	branch	NNS
cord-259603-bh198xgl	964	8	will	will	MD
cord-259603-bh198xgl	964	9	need	need	VB
cord-259603-bh198xgl	964	10	to	to	TO
cord-259603-bh198xgl	964	11	be	be	VB
cord-259603-bh198xgl	964	12	studied	study	VBN
cord-259603-bh198xgl	964	13	to	to	TO
cord-259603-bh198xgl	964	14	fully	fully	RB
cord-259603-bh198xgl	964	15	understand	understand	VB
cord-259603-bh198xgl	964	16	the	the	DT
cord-259603-bh198xgl	964	17	basic	basic	JJ
cord-259603-bh198xgl	964	18	principles	principle	NNS
cord-259603-bh198xgl	964	19	governing	govern	VBG
cord-259603-bh198xgl	964	20	the	the	DT
cord-259603-bh198xgl	964	21	profound	profound	JJ
cord-259603-bh198xgl	964	22	divergence	divergence	NN
cord-259603-bh198xgl	964	23	and	and	CC
cord-259603-bh198xgl	964	24	genome	genome	NN
cord-259603-bh198xgl	964	25	expansion	expansion	NN
cord-259603-bh198xgl	964	26	of	of	IN
cord-259603-bh198xgl	964	27	this	this	DT
cord-259603-bh198xgl	964	28	exceptional	exceptional	JJ
cord-259603-bh198xgl	964	29	order	order	NN
cord-259603-bh198xgl	964	30	of	of	IN
cord-259603-bh198xgl	964	31	+	+	SYM
cord-259603-bh198xgl	964	32	RNA	RNA	NNP
cord-259603-bh198xgl	964	33	viruses	virus	NNS
cord-259603-bh198xgl	964	34	.	.	.
cord-259603-bh198xgl	965	1	The	the	DT
cord-259603-bh198xgl	965	2	error	error	NN
cord-259603-bh198xgl	965	3	rate	rate	NN
cord-259603-bh198xgl	965	4	and	and	CC
cord-259603-bh198xgl	965	5	genomic	genomic	JJ
cord-259603-bh198xgl	965	6	plasticity	plasticity	NN
cord-259603-bh198xgl	965	7	of	of	IN
cord-259603-bh198xgl	965	8	RNA	RNA	NNP
cord-259603-bh198xgl	965	9	viruses	virus	NNS
cord-259603-bh198xgl	965	10	are	be	VBP
cord-259603-bh198xgl	965	11	among	among	IN
cord-259603-bh198xgl	965	12	their	-PRON-	PRP$
cord-259603-bh198xgl	965	13	most	most	RBS
cord-259603-bh198xgl	965	14	fascinating	fascinating	JJ
cord-259603-bh198xgl	965	15	features	feature	NNS
cord-259603-bh198xgl	965	16	,	,	,
cord-259603-bh198xgl	965	17	and	and	CC
cord-259603-bh198xgl	965	18	also	also	RB
cord-259603-bh198xgl	965	19	form	form	VB
cord-259603-bh198xgl	965	20	the	the	DT
cord-259603-bh198xgl	965	21	basis	basis	NN
cord-259603-bh198xgl	965	22	for	for	IN
cord-259603-bh198xgl	965	23	the	the	DT
cord-259603-bh198xgl	965	24	many	many	JJ
cord-259603-bh198xgl	965	25	problems	problem	NNS
cord-259603-bh198xgl	965	26	caused	cause	VBN
cord-259603-bh198xgl	965	27	by	by	IN
cord-259603-bh198xgl	965	28	RNA	RNA	NNP
cord-259603-bh198xgl	965	29	virus	virus	NN
cord-259603-bh198xgl	965	30	mutation	mutation	NN
cord-259603-bh198xgl	965	31	and	and	CC
cord-259603-bh198xgl	965	32	adaptation	adaptation	NN
cord-259603-bh198xgl	965	33	,	,	,
cord-259603-bh198xgl	965	34	including	include	VBG
cord-259603-bh198xgl	965	35	successful	successful	JJ
cord-259603-bh198xgl	965	36	zoonotic	zoonotic	JJ
cord-259603-bh198xgl	965	37	transfer	transfer	NN
cord-259603-bh198xgl	965	38	.	.	.
cord-259603-bh198xgl	966	1	As	as	IN
cord-259603-bh198xgl	966	2	exemplified	exemplify	VBN
cord-259603-bh198xgl	966	3	by	by	IN
cord-259603-bh198xgl	966	4	the	the	DT
cord-259603-bh198xgl	966	5	viable	viable	JJ
cord-259603-bh198xgl	966	6	CoV	cov	NN
cord-259603-bh198xgl	966	7	mutants	mutant	NNS
cord-259603-bh198xgl	966	8	lacking	lack	VBG
cord-259603-bh198xgl	966	9	the	the	DT
cord-259603-bh198xgl	966	10	ExoN	ExoN	NNP
cord-259603-bh198xgl	966	11	or	or	CC
cord-259603-bh198xgl	966	12	2	2	CD
cord-259603-bh198xgl	966	13	0	0	CD
cord-259603-bh198xgl	966	14	-O	-o	CD
cord-259603-bh198xgl	966	15	-	-	HYPH
cord-259603-bh198xgl	966	16	MTase	mtase	JJ
cord-259603-bh198xgl	966	17	functions	function	NNS
cord-259603-bh198xgl	966	18	(	(	-LRB-
cord-259603-bh198xgl	966	19	Graham	Graham	NNP
cord-259603-bh198xgl	966	20	et	et	NNP
cord-259603-bh198xgl	966	21	al	al	NNP
cord-259603-bh198xgl	966	22	.	.	NNP
cord-259603-bh198xgl	966	23	,	,	,
cord-259603-bh198xgl	966	24	2012	2012	CD
cord-259603-bh198xgl	967	1	;	;	:
cord-259603-bh198xgl	967	2	Habjan	Habjan	NNP
cord-259603-bh198xgl	967	3	et	et	NNP
cord-259603-bh198xgl	967	4	al	al	NNP
cord-259603-bh198xgl	967	5	.	.	.
cord-259603-bh198xgl	968	1	,	,	,
cord-259603-bh198xgl	968	2	2013	2013	CD
cord-259603-bh198xgl	968	3	;	;	:
cord-259603-bh198xgl	968	4	Menachery	Menachery	NNP
cord-259603-bh198xgl	968	5	et	et	NNP
cord-259603-bh198xgl	968	6	al	al	NNP
cord-259603-bh198xgl	968	7	.	.	.
cord-259603-bh198xgl	969	1	,	,	,
cord-259603-bh198xgl	969	2	2014	2014	CD
cord-259603-bh198xgl	969	3	;	;	:
cord-259603-bh198xgl	969	4	Z€	Z€	NNP
cord-259603-bh198xgl	969	5	ust	ust	NNP
cord-259603-bh198xgl	969	6	et	et	NNP
cord-259603-bh198xgl	969	7	al	al	NNP
cord-259603-bh198xgl	969	8	.	.	NNP
cord-259603-bh198xgl	969	9	,	,	,
cord-259603-bh198xgl	969	10	2011	2011	CD
cord-259603-bh198xgl	969	11	)	)	-RRB-
cord-259603-bh198xgl	969	12	,	,	,
cord-259603-bh198xgl	969	13	the	the	DT
cord-259603-bh198xgl	969	14	functional	functional	JJ
cord-259603-bh198xgl	969	15	characterization	characterization	NN
cord-259603-bh198xgl	969	16	of	of	IN
cord-259603-bh198xgl	969	17	CoV	cov	NN
cord-259603-bh198xgl	969	18	replicative	replicative	JJ
cord-259603-bh198xgl	969	19	enzymes	enzyme	NNS
cord-259603-bh198xgl	969	20	can	can	MD
cord-259603-bh198xgl	969	21	be	be	VB
cord-259603-bh198xgl	969	22	key	key	JJ
cord-259603-bh198xgl	969	23	to	to	IN
cord-259603-bh198xgl	969	24	the	the	DT
cord-259603-bh198xgl	969	25	development	development	NN
cord-259603-bh198xgl	969	26	of	of	IN
cord-259603-bh198xgl	969	27	conceptually	conceptually	RB
cord-259603-bh198xgl	969	28	new	new	JJ
cord-259603-bh198xgl	969	29	live	live	JJ
cord-259603-bh198xgl	969	30	attenuated	attenuated	JJ
cord-259603-bh198xgl	969	31	vaccine	vaccine	NN
cord-259603-bh198xgl	969	32	prototypes	prototype	NNS
cord-259603-bh198xgl	969	33	.	.	.
cord-259603-bh198xgl	970	1	Likewise	likewise	RB
cord-259603-bh198xgl	970	2	,	,	,
cord-259603-bh198xgl	970	3	it	-PRON-	PRP
cord-259603-bh198xgl	970	4	will	will	MD
cord-259603-bh198xgl	970	5	contribute	contribute	VB
cord-259603-bh198xgl	970	6	to	to	IN
cord-259603-bh198xgl	970	7	the	the	DT
cord-259603-bh198xgl	970	8	development	development	NN
cord-259603-bh198xgl	970	9	of	of	IN
cord-259603-bh198xgl	970	10	broad	broad	JJ
cord-259603-bh198xgl	970	11	-	-	HYPH
cord-259603-bh198xgl	970	12	spectrum	spectrum	NN
cord-259603-bh198xgl	970	13	and	and	CC
cord-259603-bh198xgl	970	14	highly	highly	RB
cord-259603-bh198xgl	970	15	effective	effective	JJ
cord-259603-bh198xgl	970	16	antiviral	antiviral	JJ
cord-259603-bh198xgl	970	17	drugs	drug	NNS
cord-259603-bh198xgl	970	18	targeting	target	VBG
cord-259603-bh198xgl	970	19	essential	essential	JJ
cord-259603-bh198xgl	970	20	enzyme	enzyme	NN
cord-259603-bh198xgl	970	21	functions	function	NNS
cord-259603-bh198xgl	970	22	,	,	,
cord-259603-bh198xgl	970	23	critical	critical	JJ
cord-259603-bh198xgl	970	24	interactions	interaction	NNS
cord-259603-bh198xgl	970	25	with	with	IN
cord-259603-bh198xgl	970	26	nsp	nsp	NN
cord-259603-bh198xgl	970	27	cofactors	cofactor	NNS
cord-259603-bh198xgl	970	28	,	,	,
cord-259603-bh198xgl	970	29	or	or	CC
cord-259603-bh198xgl	970	30	"	"	``
cord-259603-bh198xgl	970	31	nonessential	nonessential	JJ
cord-259603-bh198xgl	970	32	"	"	''
cord-259603-bh198xgl	970	33	nsp	nsp	NN
cord-259603-bh198xgl	970	34	functions	function	NNS
cord-259603-bh198xgl	970	35	that	that	WDT
cord-259603-bh198xgl	970	36	promote	promote	VBP
cord-259603-bh198xgl	970	37	efficient	efficient	JJ
cord-259603-bh198xgl	970	38	viral	viral	JJ
cord-259603-bh198xgl	970	39	replication	replication	NN
cord-259603-bh198xgl	970	40	and/or	and/or	CC
cord-259603-bh198xgl	970	41	pathogenesis	pathogenesis	NN
cord-259603-bh198xgl	970	42	.	.	.
cord-259603-bh198xgl	971	1	As	as	IN
cord-259603-bh198xgl	971	2	highlighted	highlight	VBN
cord-259603-bh198xgl	971	3	by	by	IN
cord-259603-bh198xgl	971	4	the	the	DT
cord-259603-bh198xgl	971	5	SARS	SARS	NNP
cord-259603-bh198xgl	971	6	and	and	CC
cord-259603-bh198xgl	971	7	MERS	MERS	NNP
cord-259603-bh198xgl	971	8	outbreaks	outbreak	NNS
cord-259603-bh198xgl	971	9	of	of	IN
cord-259603-bh198xgl	971	10	the	the	DT
cord-259603-bh198xgl	971	11	past	past	JJ
cord-259603-bh198xgl	971	12	15	15	CD
cord-259603-bh198xgl	971	13	years	year	NNS
cord-259603-bh198xgl	971	14	,	,	,
cord-259603-bh198xgl	971	15	having	have	VBG
cord-259603-bh198xgl	971	16	such	such	JJ
cord-259603-bh198xgl	971	17	compounds	compound	NNS
cord-259603-bh198xgl	971	18	available	available	JJ
cord-259603-bh198xgl	971	19	would	would	MD
cord-259603-bh198xgl	971	20	definitely	definitely	RB
cord-259603-bh198xgl	971	21	strengthen	strengthen	VB
cord-259603-bh198xgl	971	22	our	-PRON-	PRP$
cord-259603-bh198xgl	971	23	first	first	JJ
cord-259603-bh198xgl	971	24	line	line	NN
cord-259603-bh198xgl	971	25	of	of	IN
cord-259603-bh198xgl	971	26	defense	defense	NN
cord-259603-bh198xgl	971	27	against	against	IN
cord-259603-bh198xgl	971	28	CoV	CoV	NNP
cord-259603-bh198xgl	971	29	infections	infection	NNS
cord-259603-bh198xgl	971	30	in	in	IN
cord-259603-bh198xgl	971	31	humans	human	NNS
cord-259603-bh198xgl	971	32	.	.	.
cord-259603-bh198xgl	972	1	With	with	IN
cord-259603-bh198xgl	972	2	great	great	JJ
cord-259603-bh198xgl	972	3	respect	respect	NN
cord-259603-bh198xgl	972	4	,	,	,
cord-259603-bh198xgl	972	5	we	-PRON-	PRP
cord-259603-bh198xgl	972	6	acknowledge	acknowledge	VBP
cord-259603-bh198xgl	972	7	the	the	DT
cord-259603-bh198xgl	972	8	many	many	JJ
cord-259603-bh198xgl	972	9	ground	ground	NN
cord-259603-bh198xgl	972	10	-	-	HYPH
cord-259603-bh198xgl	972	11	breaking	break	VBG
cord-259603-bh198xgl	972	12	contributions	contribution	NNS
cord-259603-bh198xgl	972	13	of	of	IN
cord-259603-bh198xgl	972	14	our	-PRON-	PRP$
cord-259603-bh198xgl	972	15	longterm	longterm	JJ
cord-259603-bh198xgl	972	16	collaborator	collaborator	NN
cord-259603-bh198xgl	972	17	Dr.	Dr.	NNP
cord-259603-bh198xgl	972	18	Alexander	Alexander	NNP
cord-259603-bh198xgl	972	19	Gorbalenya	Gorbalenya	NNP
cord-259603-bh198xgl	972	20	,	,	,
cord-259603-bh198xgl	972	21	founding	founding	NN
cord-259603-bh198xgl	972	22	father	father	NN
cord-259603-bh198xgl	972	23	of	of	IN
cord-259603-bh198xgl	972	24	the	the	DT
cord-259603-bh198xgl	972	25	functional	functional	JJ
cord-259603-bh198xgl	972	26	characterization	characterization	NN
cord-259603-bh198xgl	972	27	of	of	IN
cord-259603-bh198xgl	972	28	the	the	DT
cord-259603-bh198xgl	972	29	replicase	replicase	NN
cord-259603-bh198xgl	972	30	of	of	IN
cord-259603-bh198xgl	972	31	coronaviruses	coronaviruses	NNPS
cord-259603-bh198xgl	972	32	and	and	CC
cord-259603-bh198xgl	972	33	nidoviruses	nidoviruse	NNS
cord-259603-bh198xgl	972	34	at	at	IN
cord-259603-bh198xgl	972	35	large	large	JJ
cord-259603-bh198xgl	972	36	.	.	.
cord-259603-bh198xgl	973	1	We	-PRON-	PRP
cord-259603-bh198xgl	973	2	are	be	VBP
cord-259603-bh198xgl	973	3	also	also	RB
cord-259603-bh198xgl	973	4	grateful	grateful	JJ
cord-259603-bh198xgl	973	5	for	for	IN
cord-259603-bh198xgl	973	6	the	the	DT
cord-259603-bh198xgl	973	7	scientific	scientific	JJ
cord-259603-bh198xgl	973	8	and	and	CC
cord-259603-bh198xgl	973	9	technical	technical	JJ
cord-259603-bh198xgl	973	10	contributions	contribution	NNS
cord-259603-bh198xgl	973	11	over	over	IN
cord-259603-bh198xgl	973	12	many	many	JJ
cord-259603-bh198xgl	973	13	years	year	NNS
cord-259603-bh198xgl	973	14	by	by	IN
cord-259603-bh198xgl	973	15	numerous	numerous	JJ
cord-259603-bh198xgl	973	16	past	past	NN
cord-259603-bh198xgl	973	17	and	and	CC
cord-259603-bh198xgl	973	18	present	present	JJ
cord-259603-bh198xgl	973	19	lab	lab	NN
cord-259603-bh198xgl	973	20	members	member	NNS
cord-259603-bh198xgl	973	21	and	and	CC
cord-259603-bh198xgl	973	22	colleagues	colleague	NNS
cord-259603-bh198xgl	973	23	in	in	IN
cord-259603-bh198xgl	973	24	Leiden	Leiden	NNP
cord-259603-bh198xgl	973	25	(	(	-LRB-
cord-259603-bh198xgl	973	26	E.J.S.	E.J.S.	NNP
cord-259603-bh198xgl	973	27	)	)	-RRB-
cord-259603-bh198xgl	973	28	,	,	,
cord-259603-bh198xgl	973	29	Marseille	Marseille	NNP
cord-259603-bh198xgl	973	30	(	(	-LRB-
cord-259603-bh198xgl	973	31	E.D.	E.D.	NNP
cord-259603-bh198xgl	973	32	)	)	-RRB-
cord-259603-bh198xgl	973	33	,	,	,
cord-259603-bh198xgl	973	34	and	and	CC
cord-259603-bh198xgl	974	1	Giessen/	Giessen/	NNP
cord-259603-bh198xgl	974	2	Belfast	Belfast	NNP
cord-259603-bh198xgl	974	3	/	/	SYM
cord-259603-bh198xgl	974	4	W€	W€	NNP
cord-259603-bh198xgl	974	5	urzburg	urzburg	NN
cord-259603-bh198xgl	974	6	(	(	-LRB-
cord-259603-bh198xgl	974	7	J.Z.	J.Z.	NNP
cord-259603-bh198xgl	974	8	)	)	-RRB-
cord-259603-bh198xgl	974	9	.	.	.
cord-259603-bh198xgl	975	1	Specifically	specifically	RB
cord-259603-bh198xgl	975	2	,	,	,
cord-259603-bh198xgl	975	3	we	-PRON-	PRP
cord-259603-bh198xgl	975	4	would	would	MD
cord-259603-bh198xgl	975	5	like	like	VB
cord-259603-bh198xgl	975	6	to	to	TO
cord-259603-bh198xgl	975	7	acknowledge	acknowledge	VB
cord-259603-bh198xgl	975	8	the	the	DT
cord-259603-bh198xgl	975	9	input	input	NN
cord-259603-bh198xgl	975	10	of	of	IN
cord-259603-bh198xgl	975	11	our	-PRON-	PRP$
cord-259603-bh198xgl	975	12	long	long	JJ
cord-259603-bh198xgl	975	13	-	-	HYPH
cord-259603-bh198xgl	975	14	term	term	NN
cord-259603-bh198xgl	975	15	collaborators	collaborator	NNS
cord-259603-bh198xgl	975	16	Clara	Clara	NNP
cord-259603-bh198xgl	975	17	Posthuma	Posthuma	NNP
cord-259603-bh198xgl	975	18	,	,	,
cord-259603-bh198xgl	975	19	Bruno	Bruno	NNP
cord-259603-bh198xgl	975	20	Canard	Canard	NNP
cord-259603-bh198xgl	975	21	,	,	,
cord-259603-bh198xgl	975	22	Bruno	Bruno	NNP
cord-259603-bh198xgl	975	23	Coutard	Coutard	NNP
cord-259603-bh198xgl	975	24	,	,	,
cord-259603-bh198xgl	975	25	Isabelle	Isabelle	NNP
cord-259603-bh198xgl	975	26	Imbert	Imbert	NNP
cord-259603-bh198xgl	975	27	,	,	,
cord-259603-bh198xgl	975	28	Volker	Volker	NNP
cord-259603-bh198xgl	975	29	Thiel	Thiel	NNP
cord-259603-bh198xgl	975	30	,	,	,
cord-259603-bh198xgl	975	31	and	and	CC
cord-259603-bh198xgl	975	32	Stuart	Stuart	NNP
cord-259603-bh198xgl	975	33	Siddell	Siddell	NNP
cord-259603-bh198xgl	975	34	.	.	.
cord-259603-bh198xgl	976	1	We	-PRON-	PRP
cord-259603-bh198xgl	976	2	thank	thank	VBP
cord-259603-bh198xgl	976	3	Aartjan	Aartjan	NNP
cord-259603-bh198xgl	976	4	te	te	NNP
cord-259603-bh198xgl	976	5	Velthuis	Velthuis	NNP
cord-259603-bh198xgl	976	6	for	for	IN
cord-259603-bh198xgl	976	7	his	-PRON-	PRP$
cord-259603-bh198xgl	976	8	assistance	assistance	NN
cord-259603-bh198xgl	976	9	with	with	IN
cord-259603-bh198xgl	976	10	preparing	prepare	VBG
cord-259603-bh198xgl	976	11	Fig	Fig	NNP
cord-259603-bh198xgl	976	12	.	.	NNP
cord-259603-bh198xgl	976	13	2	2	CD
cord-259603-bh198xgl	976	14	.	.	.
cord-259603-bh198xgl	976	15	 	 	_SP
cord-259603-bh198xgl	977	1	Mechanism	mechanism	NN
cord-259603-bh198xgl	977	2	of	of	IN
cord-259603-bh198xgl	977	3	nucleic	nucleic	JJ
cord-259603-bh198xgl	977	4	acid	acid	NN
cord-259603-bh198xgl	977	5	unwinding	unwind	VBG
cord-259603-bh198xgl	977	6	by	by	IN
cord-259603-bh198xgl	977	7	SARS	SARS	NNP
cord-259603-bh198xgl	977	8	-	-	HYPH
cord-259603-bh198xgl	977	9	CoV	CoV	NNP
cord-259603-bh198xgl	977	10	helicase	helicase	NNP
cord-259603-bh198xgl	977	11	Severe	severe	JJ
cord-259603-bh198xgl	977	12	acute	acute	JJ
cord-259603-bh198xgl	977	13	respiratory	respiratory	JJ
cord-259603-bh198xgl	977	14	syndrome	syndrome	NN
cord-259603-bh198xgl	977	15	coronavirus	coronavirus	NN
cord-259603-bh198xgl	977	16	replication	replication	NN
cord-259603-bh198xgl	977	17	inhibitor	inhibitor	NN
cord-259603-bh198xgl	977	18	that	that	WDT
cord-259603-bh198xgl	977	19	interferes	interfere	VBZ
cord-259603-bh198xgl	977	20	with	with	IN
cord-259603-bh198xgl	977	21	the	the	DT
cord-259603-bh198xgl	977	22	nucleic	nucleic	JJ
cord-259603-bh198xgl	977	23	acid	acid	NN
cord-259603-bh198xgl	977	24	unwinding	unwind	VBG
cord-259603-bh198xgl	977	25	of	of	IN
cord-259603-bh198xgl	977	26	the	the	DT
cord-259603-bh198xgl	977	27	viral	viral	JJ
cord-259603-bh198xgl	977	28	helicase	helicase	NN
cord-259603-bh198xgl	977	29	Evaluation	Evaluation	NNP
cord-259603-bh198xgl	977	30	of	of	IN
cord-259603-bh198xgl	977	31	SSYA10	SSYA10	NNP
cord-259603-bh198xgl	977	32	-	-	HYPH
cord-259603-bh198xgl	977	33	001	001	CD
cord-259603-bh198xgl	977	34	as	as	IN
cord-259603-bh198xgl	977	35	a	a	DT
cord-259603-bh198xgl	977	36	replication	replication	NN
cord-259603-bh198xgl	977	37	inhibitor	inhibitor	NN
cord-259603-bh198xgl	977	38	of	of	IN
cord-259603-bh198xgl	977	39	severe	severe	JJ
cord-259603-bh198xgl	977	40	acute	acute	JJ
cord-259603-bh198xgl	977	41	respiratory	respiratory	JJ
cord-259603-bh198xgl	977	42	syndrome	syndrome	NN
cord-259603-bh198xgl	977	43	,	,	,
cord-259603-bh198xgl	977	44	mouse	mouse	NN
cord-259603-bh198xgl	977	45	hepatitis	hepatitis	NN
cord-259603-bh198xgl	977	46	,	,	,
cord-259603-bh198xgl	977	47	and	and	CC
cord-259603-bh198xgl	977	48	Middle	Middle	NNP
cord-259603-bh198xgl	977	49	East	East	NNP
cord-259603-bh198xgl	977	50	respiratory	respiratory	JJ
cord-259603-bh198xgl	977	51	syndrome	syndrome	NN
cord-259603-bh198xgl	977	52	coronaviruses	coronaviruse	NNS
cord-259603-bh198xgl	977	53	.	.	.
cord-259603-bh198xgl	978	1	Antimicrob	Antimicrob	NNP
cord-259603-bh198xgl	978	2	Biochemical	biochemical	JJ
cord-259603-bh198xgl	978	3	characterization	characterization	NN
cord-259603-bh198xgl	978	4	of	of	IN
cord-259603-bh198xgl	978	5	a	a	DT
cord-259603-bh198xgl	978	6	recombinant	recombinant	JJ
cord-259603-bh198xgl	978	7	SARS	SARS	NNP
cord-259603-bh198xgl	978	8	coronavirus	coronavirus	NN
cord-259603-bh198xgl	979	1	nsp12	nsp12	NNP
cord-259603-bh198xgl	979	2	RNA	RNA	NNP
cord-259603-bh198xgl	979	3	-	-	HYPH
cord-259603-bh198xgl	979	4	dependent	dependent	JJ
cord-259603-bh198xgl	979	5	RNA	RNA	NNP
cord-259603-bh198xgl	979	6	polymerase	polymerase	NN
cord-259603-bh198xgl	979	7	capable	capable	JJ
cord-259603-bh198xgl	979	8	of	of	IN
cord-259603-bh198xgl	979	9	copying	copy	VBG
cord-259603-bh198xgl	979	10	viral	viral	JJ
cord-259603-bh198xgl	979	11	RNA	RNA	NNP
cord-259603-bh198xgl	979	12	templates	template	NNS
cord-259603-bh198xgl	979	13	Putative	Putative	NNP
cord-259603-bh198xgl	979	14	RNA	RNA	NNP
cord-259603-bh198xgl	979	15	capping	cap	VBG
cord-259603-bh198xgl	979	16	activities	activity	NNS
cord-259603-bh198xgl	979	17	encoded	encode	VBN
cord-259603-bh198xgl	979	18	by	by	IN
cord-259603-bh198xgl	979	19	brome	brome	NNP
cord-259603-bh198xgl	979	20	mosaic	mosaic	NNP
cord-259603-bh198xgl	979	21	virus	virus	NN
cord-259603-bh198xgl	979	22	:	:	:
cord-259603-bh198xgl	979	23	methylation	methylation	NN
cord-259603-bh198xgl	979	24	and	and	CC
cord-259603-bh198xgl	979	25	covalent	covalent	JJ
cord-259603-bh198xgl	979	26	binding	binding	NN
cord-259603-bh198xgl	979	27	of	of	IN
cord-259603-bh198xgl	979	28	guanylate	guanylate	NN
cord-259603-bh198xgl	979	29	by	by	IN
cord-259603-bh198xgl	979	30	replicase	replicase	NNP
cord-259603-bh198xgl	979	31	protein	protein	NNP
cord-259603-bh198xgl	979	32	1a	1a	NNP
cord-259603-bh198xgl	979	33	Construction	Construction	NNP
cord-259603-bh198xgl	979	34	of	of	IN
cord-259603-bh198xgl	979	35	a	a	DT
cord-259603-bh198xgl	979	36	severe	severe	JJ
cord-259603-bh198xgl	979	37	acute	acute	JJ
cord-259603-bh198xgl	979	38	respiratory	respiratory	JJ
cord-259603-bh198xgl	979	39	syndrome	syndrome	NN
cord-259603-bh198xgl	979	40	coronavirus	coronavirus	NN
cord-259603-bh198xgl	979	41	infectious	infectious	JJ
cord-259603-bh198xgl	979	42	cDNA	cdna	NN
cord-259603-bh198xgl	979	43	clone	clone	NN
cord-259603-bh198xgl	979	44	and	and	CC
cord-259603-bh198xgl	979	45	a	a	DT
cord-259603-bh198xgl	979	46	replicon	replicon	NN
cord-259603-bh198xgl	979	47	to	to	TO
cord-259603-bh198xgl	979	48	study	study	VB
cord-259603-bh198xgl	979	49	coronavirus	coronavirus	NN
cord-259603-bh198xgl	979	50	RNA	RNA	NNP
cord-259603-bh198xgl	979	51	synthesis	synthesis	NN
cord-259603-bh198xgl	979	52	Coronavirus	Coronavirus	NNP
cord-259603-bh198xgl	979	53	reverse	reverse	VBP
cord-259603-bh198xgl	979	54	genetic	genetic	JJ
cord-259603-bh198xgl	979	55	systems	system	NNS
cord-259603-bh198xgl	979	56	:	:	:
cord-259603-bh198xgl	979	57	infectious	infectious	JJ
cord-259603-bh198xgl	979	58	clones	clone	NNS
cord-259603-bh198xgl	979	59	and	and	CC
cord-259603-bh198xgl	979	60	replicons	replicon	NNS
cord-259603-bh198xgl	979	61	Structure	Structure	NNP
cord-259603-bh198xgl	979	62	of	of	IN
cord-259603-bh198xgl	979	63	coronavirus	coronavirus	NN
cord-259603-bh198xgl	979	64	main	main	JJ
cord-259603-bh198xgl	979	65	proteinase	proteinase	NN
cord-259603-bh198xgl	979	66	reveals	reveal	VBZ
cord-259603-bh198xgl	979	67	combination	combination	NN
cord-259603-bh198xgl	979	68	of	of	IN
cord-259603-bh198xgl	979	69	a	a	DT
cord-259603-bh198xgl	979	70	chymotrypsin	chymotrypsin	NN
cord-259603-bh198xgl	979	71	fold	fold	JJ
cord-259603-bh198xgl	979	72	with	with	IN
cord-259603-bh198xgl	979	73	an	an	DT
cord-259603-bh198xgl	979	74	extra	extra	JJ
cord-259603-bh198xgl	979	75	alpha	alpha	JJ
cord-259603-bh198xgl	979	76	-	-	HYPH
cord-259603-bh198xgl	979	77	helical	helical	JJ
cord-259603-bh198xgl	979	78	domain	domain	NN
cord-259603-bh198xgl	979	79	Coronavirus	Coronavirus	NNP
cord-259603-bh198xgl	979	80	main	main	JJ
cord-259603-bh198xgl	979	81	proteinase	proteinase	NN
cord-259603-bh198xgl	979	82	(	(	-LRB-
cord-259603-bh198xgl	979	83	3CLpro	3clpro	CD
cord-259603-bh198xgl	979	84	)	)	-RRB-
cord-259603-bh198xgl	979	85	structure	structure	NN
cord-259603-bh198xgl	979	86	:	:	:
cord-259603-bh198xgl	979	87	basis	basis	NN
cord-259603-bh198xgl	979	88	for	for	IN
cord-259603-bh198xgl	979	89	design	design	NN
cord-259603-bh198xgl	979	90	of	of	IN
cord-259603-bh198xgl	979	91	anti	anti	JJ
cord-259603-bh198xgl	979	92	-	-	JJ
cord-259603-bh198xgl	979	93	SARS	SARS	NNP
cord-259603-bh198xgl	979	94	drugs	drug	NNS
cord-259603-bh198xgl	979	95	Severe	severe	VBP
cord-259603-bh198xgl	979	96	acute	acute	JJ
cord-259603-bh198xgl	979	97	respiratory	respiratory	JJ
cord-259603-bh198xgl	979	98	syndrome	syndrome	NN
cord-259603-bh198xgl	979	99	coronavirus	coronavirus	NN
cord-259603-bh198xgl	979	100	nonstructural	nonstructural	JJ
cord-259603-bh198xgl	979	101	proteins	protein	NNS
cord-259603-bh198xgl	979	102	3	3	CD
cord-259603-bh198xgl	979	103	,	,	,
cord-259603-bh198xgl	979	104	4	4	CD
cord-259603-bh198xgl	979	105	,	,	,
cord-259603-bh198xgl	979	106	and	and	CC
cord-259603-bh198xgl	979	107	6	6	CD
cord-259603-bh198xgl	979	108	induce	induce	VBP
cord-259603-bh198xgl	979	109	doublemembrane	doublemembrane	NNS
cord-259603-bh198xgl	979	110	vesicles	vesicle	NNS
cord-259603-bh198xgl	980	1	The	the	DT
cord-259603-bh198xgl	980	2	SARS	SARS	NNP
cord-259603-bh198xgl	980	3	-	-	HYPH
cord-259603-bh198xgl	980	4	coronavirus	coronavirus	NN
cord-259603-bh198xgl	980	5	papain	papain	NN
cord-259603-bh198xgl	980	6	-	-	HYPH
cord-259603-bh198xgl	980	7	like	like	JJ
cord-259603-bh198xgl	980	8	protease	protease	NN
cord-259603-bh198xgl	980	9	:	:	:
cord-259603-bh198xgl	980	10	structure	structure	NN
cord-259603-bh198xgl	980	11	,	,	,
cord-259603-bh198xgl	980	12	function	function	NN
cord-259603-bh198xgl	980	13	and	and	CC
cord-259603-bh198xgl	980	14	inhibition	inhibition	NN
cord-259603-bh198xgl	980	15	by	by	IN
cord-259603-bh198xgl	980	16	designed	design	VBN
cord-259603-bh198xgl	980	17	antiviral	antiviral	JJ
cord-259603-bh198xgl	980	18	compounds	compound	NNS
cord-259603-bh198xgl	980	19	Enhancement	Enhancement	NNP
cord-259603-bh198xgl	980	20	of	of	IN
cord-259603-bh198xgl	980	21	the	the	DT
cord-259603-bh198xgl	980	22	infectivity	infectivity	NN
cord-259603-bh198xgl	980	23	of	of	IN
cord-259603-bh198xgl	980	24	SARS	SARS	NNP
cord-259603-bh198xgl	980	25	-	-	HYPH
cord-259603-bh198xgl	980	26	CoV	CoV	NNP
cord-259603-bh198xgl	980	27	in	in	IN
cord-259603-bh198xgl	980	28	BALB	BALB	NNP
cord-259603-bh198xgl	980	29	/	/	SYM
cord-259603-bh198xgl	980	30	c	c	NN
cord-259603-bh198xgl	980	31	mice	mouse	NNS
cord-259603-bh198xgl	980	32	by	by	IN
cord-259603-bh198xgl	980	33	IMP	IMP	NNP
cord-259603-bh198xgl	980	34	dehydrogenase	dehydrogenase	NN
cord-259603-bh198xgl	980	35	inhibitors	inhibitor	NNS
cord-259603-bh198xgl	980	36	,	,	,
cord-259603-bh198xgl	980	37	including	include	VBG
cord-259603-bh198xgl	980	38	ribavirin	ribavirin	NNP
cord-259603-bh198xgl	980	39	Mutagenesis	Mutagenesis	NNP
cord-259603-bh198xgl	980	40	of	of	IN
cord-259603-bh198xgl	980	41	coronavirus	coronavirus	NN
cord-259603-bh198xgl	980	42	nsp14	nsp14	XX
cord-259603-bh198xgl	980	43	reveals	reveal	VBZ
cord-259603-bh198xgl	980	44	its	-PRON-	PRP$
cord-259603-bh198xgl	980	45	potential	potential	JJ
cord-259603-bh198xgl	980	46	role	role	NN
cord-259603-bh198xgl	980	47	in	in	IN
cord-259603-bh198xgl	980	48	modulation	modulation	NN
cord-259603-bh198xgl	980	49	of	of	IN
cord-259603-bh198xgl	980	50	the	the	DT
cord-259603-bh198xgl	980	51	innate	innate	JJ
cord-259603-bh198xgl	980	52	immune	immune	JJ
cord-259603-bh198xgl	980	53	response	response	NN
cord-259603-bh198xgl	980	54	De	De	NNP
cord-259603-bh198xgl	980	55	novo	novo	NNP
cord-259603-bh198xgl	980	56	initiation	initiation	NN
cord-259603-bh198xgl	980	57	of	of	IN
cord-259603-bh198xgl	980	58	RNA	RNA	NNP
cord-259603-bh198xgl	980	59	synthesis	synthesis	NN
cord-259603-bh198xgl	980	60	by	by	IN
cord-259603-bh198xgl	980	61	the	the	DT
cord-259603-bh198xgl	980	62	arterivirus	arterivirus	NNP
cord-259603-bh198xgl	980	63	RNA	RNA	NNP
cord-259603-bh198xgl	980	64	-	-	HYPH
cord-259603-bh198xgl	980	65	dependent	dependent	JJ
cord-259603-bh198xgl	980	66	RNA	RNA	NNP
cord-259603-bh198xgl	980	67	polymerase	polymerase	NN
cord-259603-bh198xgl	980	68	Structural	structural	JJ
cord-259603-bh198xgl	980	69	basis	basis	NN
cord-259603-bh198xgl	980	70	for	for	IN
cord-259603-bh198xgl	980	71	the	the	DT
cord-259603-bh198xgl	980	72	3	3	CD
cord-259603-bh198xgl	980	73	0	0	CD
cord-259603-bh198xgl	980	74	-5	-5	CD
cord-259603-bh198xgl	980	75	0	0	CD
cord-259603-bh198xgl	980	76	exonuclease	exonuclease	NN
cord-259603-bh198xgl	980	77	activity	activity	NN
cord-259603-bh198xgl	980	78	of	of	IN
cord-259603-bh198xgl	980	79	Escherichia	Escherichia	NNP
cord-259603-bh198xgl	980	80	coli	coli	VBZ
cord-259603-bh198xgl	980	81	DNA	dna	NN
cord-259603-bh198xgl	980	82	polymerase	polymerase	NN
cord-259603-bh198xgl	980	83	I	-PRON-	PRP
cord-259603-bh198xgl	980	84	:	:	:
cord-259603-bh198xgl	980	85	a	a	DT
cord-259603-bh198xgl	980	86	two	two	CD
cord-259603-bh198xgl	980	87	metal	metal	NN
cord-259603-bh198xgl	980	88	ion	ion	NN
cord-259603-bh198xgl	980	89	mechanism	mechanism	NN
cord-259603-bh198xgl	980	90	Structure	Structure	NNP
cord-259603-bh198xgl	980	91	of	of	IN
cord-259603-bh198xgl	980	92	DNA	dna	NN
cord-259603-bh198xgl	980	93	polymerase	polymerase	NN
cord-259603-bh198xgl	980	94	I	-PRON-	PRP
cord-259603-bh198xgl	980	95	Klenow	Klenow	NNP
cord-259603-bh198xgl	980	96	fragment	fragment	NN
cord-259603-bh198xgl	980	97	bound	bind	VBN
cord-259603-bh198xgl	980	98	to	to	IN
cord-259603-bh198xgl	980	99	duplex	duplex	JJ
cord-259603-bh198xgl	980	100	DNA	DNA	NNP
cord-259603-bh198xgl	980	101	Tertiary	Tertiary	NNP
cord-259603-bh198xgl	980	102	structure	structure	NN
cord-259603-bh198xgl	980	103	prediction	prediction	NN
cord-259603-bh198xgl	980	104	of	of	IN
cord-259603-bh198xgl	981	1	SARS	SARS	NNP
cord-259603-bh198xgl	981	2	coronavirus	coronavirus	NN
cord-259603-bh198xgl	981	3	helicase	helicase	NNP
cord-259603-bh198xgl	982	1	The	the	DT
cord-259603-bh198xgl	982	2	severe	severe	JJ
cord-259603-bh198xgl	982	3	acute	acute	JJ
cord-259603-bh198xgl	982	4	respiratory	respiratory	JJ
cord-259603-bh198xgl	982	5	syndrome	syndrome	NN
cord-259603-bh198xgl	982	6	coronavirus	coronavirus	NN
cord-259603-bh198xgl	983	1	Nsp15	Nsp15	NNP
cord-259603-bh198xgl	983	2	protein	protein	NN
cord-259603-bh198xgl	983	3	is	be	VBZ
cord-259603-bh198xgl	983	4	an	an	DT
cord-259603-bh198xgl	983	5	endoribonuclease	endoribonuclease	NN
cord-259603-bh198xgl	983	6	that	that	WDT
cord-259603-bh198xgl	983	7	prefers	prefer	VBZ
cord-259603-bh198xgl	983	8	manganese	manganese	NN
cord-259603-bh198xgl	983	9	as	as	IN
cord-259603-bh198xgl	983	10	a	a	DT
cord-259603-bh198xgl	983	11	cofactor	cofactor	NN
cord-259603-bh198xgl	983	12	RNA	RNA	NNP
cord-259603-bh198xgl	983	13	recognition	recognition	NN
cord-259603-bh198xgl	983	14	and	and	CC
cord-259603-bh198xgl	983	15	cleavage	cleavage	NN
cord-259603-bh198xgl	983	16	by	by	IN
cord-259603-bh198xgl	983	17	the	the	DT
cord-259603-bh198xgl	983	18	SARS	SARS	NNP
cord-259603-bh198xgl	983	19	coronavirus	coronavirus	NN
cord-259603-bh198xgl	983	20	endoribonuclease	endoribonuclease	NNP
cord-259603-bh198xgl	983	21	Structural	structural	JJ
cord-259603-bh198xgl	983	22	and	and	CC
cord-259603-bh198xgl	983	23	functional	functional	JJ
cord-259603-bh198xgl	983	24	analyses	analysis	NNS
cord-259603-bh198xgl	983	25	of	of	IN
cord-259603-bh198xgl	983	26	the	the	DT
cord-259603-bh198xgl	983	27	severe	severe	JJ
cord-259603-bh198xgl	983	28	acute	acute	JJ
cord-259603-bh198xgl	983	29	respiratory	respiratory	JJ
cord-259603-bh198xgl	983	30	syndrome	syndrome	NN
cord-259603-bh198xgl	983	31	coronavirus	coronavirus	NN
cord-259603-bh198xgl	983	32	endoribonuclease	endoribonuclease	NN
cord-259603-bh198xgl	983	33	Nsp15	Nsp15	NNP
cord-259603-bh198xgl	983	34	Four	Four	NNP
cord-259603-bh198xgl	983	35	proteins	protein	NNS
cord-259603-bh198xgl	983	36	processed	process	VBN
cord-259603-bh198xgl	983	37	from	from	IN
cord-259603-bh198xgl	983	38	the	the	DT
cord-259603-bh198xgl	983	39	replicase	replicase	NNP
cord-259603-bh198xgl	983	40	gene	gene	NNP
cord-259603-bh198xgl	983	41	polyprotein	polyprotein	NNP
cord-259603-bh198xgl	983	42	of	of	IN
cord-259603-bh198xgl	983	43	mouse	mouse	NNP
cord-259603-bh198xgl	983	44	hepatitis	hepatitis	NNP
cord-259603-bh198xgl	983	45	virus	virus	NN
cord-259603-bh198xgl	983	46	colocalize	colocalize	NN
cord-259603-bh198xgl	983	47	in	in	IN
cord-259603-bh198xgl	983	48	the	the	DT
cord-259603-bh198xgl	983	49	cell	cell	NN
cord-259603-bh198xgl	983	50	periphery	periphery	NN
cord-259603-bh198xgl	983	51	and	and	CC
cord-259603-bh198xgl	983	52	adjacent	adjacent	JJ
cord-259603-bh198xgl	983	53	to	to	IN
cord-259603-bh198xgl	983	54	sites	site	NNS
cord-259603-bh198xgl	983	55	of	of	IN
cord-259603-bh198xgl	983	56	virion	virion	NN
cord-259603-bh198xgl	983	57	assembly	assembly	NN
cord-259603-bh198xgl	983	58	Completion	completion	NN
cord-259603-bh198xgl	983	59	of	of	IN
cord-259603-bh198xgl	983	60	the	the	DT
cord-259603-bh198xgl	983	61	sequence	sequence	NN
cord-259603-bh198xgl	983	62	of	of	IN
cord-259603-bh198xgl	983	63	the	the	DT
cord-259603-bh198xgl	983	64	genome	genome	NN
cord-259603-bh198xgl	983	65	of	of	IN
cord-259603-bh198xgl	983	66	the	the	DT
cord-259603-bh198xgl	983	67	coronavirus	coronavirus	NN
cord-259603-bh198xgl	983	68	avian	avian	JJ
cord-259603-bh198xgl	983	69	infectious	infectious	JJ
cord-259603-bh198xgl	983	70	bronchitis	bronchitis	NN
cord-259603-bh198xgl	983	71	virus	virus	NN
cord-259603-bh198xgl	984	1	In	in	IN
cord-259603-bh198xgl	984	2	vitro	vitro	FW
cord-259603-bh198xgl	984	3	reconstitution	reconstitution	NN
cord-259603-bh198xgl	984	4	of	of	IN
cord-259603-bh198xgl	984	5	SARS	SARS	NNP
cord-259603-bh198xgl	984	6	-	-	HYPH
cord-259603-bh198xgl	984	7	coronavirus	coronavirus	NN
cord-259603-bh198xgl	984	8	mRNA	mrna	NN
cord-259603-bh198xgl	984	9	cap	cap	NN
cord-259603-bh198xgl	984	10	methylation	methylation	NN
cord-259603-bh198xgl	984	11	RNA	RNA	NNP
cord-259603-bh198xgl	984	12	3	3	CD
cord-259603-bh198xgl	984	13	0	0	CD
cord-259603-bh198xgl	984	14	-end	-end	NN
cord-259603-bh198xgl	984	15	mismatch	mismatch	NN
cord-259603-bh198xgl	984	16	excision	excision	NN
cord-259603-bh198xgl	984	17	by	by	IN
cord-259603-bh198xgl	984	18	the	the	DT
cord-259603-bh198xgl	984	19	severe	severe	JJ
cord-259603-bh198xgl	984	20	acute	acute	JJ
cord-259603-bh198xgl	984	21	respiratory	respiratory	JJ
cord-259603-bh198xgl	984	22	syndrome	syndrome	NN
cord-259603-bh198xgl	984	23	coronavirus	coronavirus	NN
cord-259603-bh198xgl	984	24	nonstructural	nonstructural	JJ
cord-259603-bh198xgl	984	25	protein	protein	NN
cord-259603-bh198xgl	985	1	nsp10	nsp10	NNP
cord-259603-bh198xgl	985	2	/	/	SYM
cord-259603-bh198xgl	985	3	nsp14	nsp14	XX
cord-259603-bh198xgl	986	1	exoribonuclease	exoribonuclease	NNP
cord-259603-bh198xgl	986	2	complex	complex	JJ
cord-259603-bh198xgl	986	3	Coronavirus	Coronavirus	NNP
cord-259603-bh198xgl	986	4	Nsp10	Nsp10	NNP
cord-259603-bh198xgl	986	5	,	,	,
cord-259603-bh198xgl	986	6	a	a	DT
cord-259603-bh198xgl	986	7	critical	critical	JJ
cord-259603-bh198xgl	986	8	co	co	NN
cord-259603-bh198xgl	986	9	-	-	NN
cord-259603-bh198xgl	986	10	factor	factor	NN
cord-259603-bh198xgl	986	11	for	for	IN
cord-259603-bh198xgl	986	12	activation	activation	NN
cord-259603-bh198xgl	986	13	of	of	IN
cord-259603-bh198xgl	986	14	multiple	multiple	JJ
cord-259603-bh198xgl	986	15	replicative	replicative	JJ
cord-259603-bh198xgl	986	16	enzymes	enzyme	NNS
cord-259603-bh198xgl	986	17	Characterization	characterization	NN
cord-259603-bh198xgl	986	18	of	of	IN
cord-259603-bh198xgl	986	19	an	an	DT
cord-259603-bh198xgl	986	20	efficient	efficient	JJ
cord-259603-bh198xgl	986	21	coronavirus	coronavirus	NN
cord-259603-bh198xgl	986	22	ribosomal	ribosomal	NN
cord-259603-bh198xgl	986	23	frameshifting	frameshifte	VBG
cord-259603-bh198xgl	986	24	signal	signal	NN
cord-259603-bh198xgl	986	25	:	:	:
cord-259603-bh198xgl	986	26	requirement	requirement	NN
cord-259603-bh198xgl	986	27	for	for	IN
cord-259603-bh198xgl	986	28	an	an	DT
cord-259603-bh198xgl	986	29	RNA	RNA	NNP
cord-259603-bh198xgl	986	30	pseudoknot	pseudoknot	NN
cord-259603-bh198xgl	986	31	Characterization	characterization	NN
cord-259603-bh198xgl	986	32	of	of	IN
cord-259603-bh198xgl	986	33	the	the	DT
cord-259603-bh198xgl	986	34	expression	expression	NN
cord-259603-bh198xgl	986	35	,	,	,
cord-259603-bh198xgl	986	36	intracellular	intracellular	JJ
cord-259603-bh198xgl	986	37	localization	localization	NN
cord-259603-bh198xgl	986	38	,	,	,
cord-259603-bh198xgl	986	39	and	and	CC
cord-259603-bh198xgl	986	40	replication	replication	NN
cord-259603-bh198xgl	986	41	complex	complex	NNP
cord-259603-bh198xgl	986	42	association	association	NNP
cord-259603-bh198xgl	986	43	of	of	IN
cord-259603-bh198xgl	986	44	the	the	DT
cord-259603-bh198xgl	986	45	putative	putative	JJ
cord-259603-bh198xgl	986	46	mouse	mouse	NN
cord-259603-bh198xgl	986	47	hepatitis	hepatitis	NNP
cord-259603-bh198xgl	986	48	virus	virus	NN
cord-259603-bh198xgl	986	49	RNA	RNA	NNP
cord-259603-bh198xgl	986	50	-	-	HYPH
cord-259603-bh198xgl	986	51	dependent	dependent	JJ
cord-259603-bh198xgl	986	52	RNA	RNA	NNP
cord-259603-bh198xgl	986	53	polymerase	polymerase	NN
cord-259603-bh198xgl	986	54	Intracellular	Intracellular	NNP
cord-259603-bh198xgl	986	55	localization	localization	NN
cord-259603-bh198xgl	986	56	and	and	CC
cord-259603-bh198xgl	986	57	protein	protein	NN
cord-259603-bh198xgl	986	58	interactions	interaction	NNS
cord-259603-bh198xgl	986	59	of	of	IN
cord-259603-bh198xgl	986	60	the	the	DT
cord-259603-bh198xgl	986	61	gene	gene	NN
cord-259603-bh198xgl	986	62	1	1	CD
cord-259603-bh198xgl	986	63	protein	protein	NN
cord-259603-bh198xgl	986	64	p28	p28	NN
cord-259603-bh198xgl	986	65	during	during	IN
cord-259603-bh198xgl	986	66	mouse	mouse	NN
cord-259603-bh198xgl	986	67	hepatitis	hepatitis	NN
cord-259603-bh198xgl	986	68	virus	virus	NN
cord-259603-bh198xgl	986	69	replication	replication	NN
cord-259603-bh198xgl	986	70	Genus	Genus	NNP
cord-259603-bh198xgl	986	71	Torovirus	Torovirus	NNP
cord-259603-bh198xgl	986	72	assigned	assign	VBN
cord-259603-bh198xgl	986	73	to	to	IN
cord-259603-bh198xgl	986	74	the	the	DT
cord-259603-bh198xgl	986	75	Coronaviridae	Coronaviridae	NNP
cord-259603-bh198xgl	986	76	Biochemical	biochemical	JJ
cord-259603-bh198xgl	986	77	characterization	characterization	NN
cord-259603-bh198xgl	986	78	of	of	IN
cord-259603-bh198xgl	986	79	exoribonuclease	exoribonuclease	NN
cord-259603-bh198xgl	986	80	encoded	encode	VBN
cord-259603-bh198xgl	986	81	by	by	IN
cord-259603-bh198xgl	986	82	SARS	SARS	NNP
cord-259603-bh198xgl	986	83	coronavirus	coronavirus	NN
cord-259603-bh198xgl	986	84	Formation	Formation	NNP
cord-259603-bh198xgl	986	85	of	of	IN
cord-259603-bh198xgl	986	86	stable	stable	JJ
cord-259603-bh198xgl	986	87	homodimer	homodimer	JJ
cord-259603-bh198xgl	986	88	via	via	IN
cord-259603-bh198xgl	986	89	the	the	DT
cord-259603-bh198xgl	986	90	C	C	NNP
cord-259603-bh198xgl	986	91	-	-	HYPH
cord-259603-bh198xgl	986	92	terminal	terminal	JJ
cord-259603-bh198xgl	986	93	alpha	alpha	JJ
cord-259603-bh198xgl	986	94	-	-	HYPH
cord-259603-bh198xgl	986	95	helical	helical	JJ
cord-259603-bh198xgl	986	96	domain	domain	NN
cord-259603-bh198xgl	986	97	of	of	IN
cord-259603-bh198xgl	986	98	coronavirus	coronavirus	NN
cord-259603-bh198xgl	986	99	nonstructural	nonstructural	JJ
cord-259603-bh198xgl	986	100	protein	protein	NN
cord-259603-bh198xgl	986	101	9	9	CD
cord-259603-bh198xgl	986	102	is	be	VBZ
cord-259603-bh198xgl	986	103	critical	critical	JJ
cord-259603-bh198xgl	986	104	for	for	IN
cord-259603-bh198xgl	986	105	its	-PRON-	PRP$
cord-259603-bh198xgl	986	106	function	function	NN
cord-259603-bh198xgl	986	107	in	in	IN
cord-259603-bh198xgl	986	108	viral	viral	JJ
cord-259603-bh198xgl	986	109	replication	replication	NN
cord-259603-bh198xgl	986	110	Interaction	Interaction	NNP
cord-259603-bh198xgl	986	111	between	between	IN
cord-259603-bh198xgl	986	112	SARS	SARS	NNP
cord-259603-bh198xgl	986	113	-	-	HYPH
cord-259603-bh198xgl	986	114	CoV	CoV	NNP
cord-259603-bh198xgl	986	115	helicase	helicase	NN
cord-259603-bh198xgl	986	116	and	and	CC
cord-259603-bh198xgl	986	117	a	a	DT
cord-259603-bh198xgl	986	118	multifunctional	multifunctional	JJ
cord-259603-bh198xgl	986	119	cellular	cellular	JJ
cord-259603-bh198xgl	986	120	protein	protein	NN
cord-259603-bh198xgl	986	121	(	(	-LRB-
cord-259603-bh198xgl	986	122	Ddx5	Ddx5	NNP
cord-259603-bh198xgl	986	123	)	)	-RRB-
cord-259603-bh198xgl	986	124	revealed	reveal	VBN
cord-259603-bh198xgl	986	125	by	by	IN
cord-259603-bh198xgl	986	126	yeast	yeast	NN
cord-259603-bh198xgl	986	127	and	and	CC
cord-259603-bh198xgl	986	128	mammalian	mammalian	JJ
cord-259603-bh198xgl	986	129	cell	cell	NN
cord-259603-bh198xgl	986	130	two	two	CD
cord-259603-bh198xgl	986	131	-	-	HYPH
cord-259603-bh198xgl	986	132	hybrid	hybrid	NN
cord-259603-bh198xgl	986	133	systems	system	NNS
cord-259603-bh198xgl	986	134	Functional	functional	JJ
cord-259603-bh198xgl	986	135	screen	screen	NN
cord-259603-bh198xgl	986	136	reveals	reveal	VBZ
cord-259603-bh198xgl	986	137	SARS	SARS	NNP
cord-259603-bh198xgl	986	138	coronavirus	coronavirus	NN
cord-259603-bh198xgl	986	139	nonstructural	nonstructural	JJ
cord-259603-bh198xgl	986	140	protein	protein	NN
cord-259603-bh198xgl	987	1	nsp14	nsp14	NFP
cord-259603-bh198xgl	987	2	as	as	IN
cord-259603-bh198xgl	987	3	a	a	DT
cord-259603-bh198xgl	987	4	novel	novel	NN
cord-259603-bh198xgl	987	5	cap	cap	NN
cord-259603-bh198xgl	987	6	N7	N7	NNP
cord-259603-bh198xgl	987	7	methyltransferase	methyltransferase	NN
cord-259603-bh198xgl	987	8	Biochemical	biochemical	JJ
cord-259603-bh198xgl	987	9	and	and	CC
cord-259603-bh198xgl	987	10	structural	structural	JJ
cord-259603-bh198xgl	987	11	insights	insight	NNS
cord-259603-bh198xgl	987	12	into	into	IN
cord-259603-bh198xgl	987	13	the	the	DT
cord-259603-bh198xgl	987	14	mechanisms	mechanism	NNS
cord-259603-bh198xgl	987	15	of	of	IN
cord-259603-bh198xgl	987	16	SARS	SARS	NNP
cord-259603-bh198xgl	987	17	coronavirus	coronavirus	NN
cord-259603-bh198xgl	987	18	RNA	RNA	NNP
cord-259603-bh198xgl	987	19	ribose	ribose	NN
cord-259603-bh198xgl	987	20	2	2	CD
cord-259603-bh198xgl	987	21	0	0	CD
cord-259603-bh198xgl	987	22	-O	-o	CD
cord-259603-bh198xgl	987	23	-	-	HYPH
cord-259603-bh198xgl	987	24	methylation	methylation	NN
cord-259603-bh198xgl	987	25	by	by	IN
cord-259603-bh198xgl	987	26	nsp16	nsp16	NNS
cord-259603-bh198xgl	987	27	/	/	SYM
cord-259603-bh198xgl	987	28	nsp10	nsp10	NNP
cord-259603-bh198xgl	987	29	protein	protein	NN
cord-259603-bh198xgl	987	30	complex	complex	NN
cord-259603-bh198xgl	987	31	Expression	expression	NN
cord-259603-bh198xgl	987	32	,	,	,
cord-259603-bh198xgl	987	33	purification	purification	NN
cord-259603-bh198xgl	987	34	,	,	,
cord-259603-bh198xgl	987	35	and	and	CC
cord-259603-bh198xgl	987	36	characterization	characterization	NN
cord-259603-bh198xgl	987	37	of	of	IN
cord-259603-bh198xgl	987	38	SARS	SARS	NNP
cord-259603-bh198xgl	987	39	coronavirus	coronavirus	NN
cord-259603-bh198xgl	987	40	RNA	RNA	NNP
cord-259603-bh198xgl	987	41	polymerase	polymerase	NN
cord-259603-bh198xgl	987	42	Structural	structural	JJ
cord-259603-bh198xgl	987	43	and	and	CC
cord-259603-bh198xgl	987	44	functional	functional	JJ
cord-259603-bh198xgl	987	45	insights	insight	NNS
cord-259603-bh198xgl	987	46	into	into	IN
cord-259603-bh198xgl	987	47	the	the	DT
cord-259603-bh198xgl	987	48	human	human	JJ
cord-259603-bh198xgl	987	49	Upf1	Upf1	NNP
cord-259603-bh198xgl	987	50	helicase	helicase	NN
cord-259603-bh198xgl	987	51	core	core	NN
cord-259603-bh198xgl	987	52	Antiviral	antiviral	JJ
cord-259603-bh198xgl	987	53	activity	activity	NN
cord-259603-bh198xgl	987	54	of	of	IN
cord-259603-bh198xgl	987	55	nucleoside	nucleoside	JJ
cord-259603-bh198xgl	987	56	analogues	analogue	NNS
cord-259603-bh198xgl	987	57	against	against	IN
cord-259603-bh198xgl	987	58	SARS	SARS	NNP
cord-259603-bh198xgl	987	59	-	-	HYPH
cord-259603-bh198xgl	987	60	coronavirus	coronavirus	NN
cord-259603-bh198xgl	987	61	(	(	-LRB-
cord-259603-bh198xgl	987	62	SARS	SARS	NNP
cord-259603-bh198xgl	987	63	-	-	HYPH
cord-259603-bh198xgl	987	64	coV	coV	NNP
cord-259603-bh198xgl	987	65	)	)	-RRB-
cord-259603-bh198xgl	988	1	Unusual	unusual	JJ
cord-259603-bh198xgl	988	2	bipartite	bipartite	JJ
cord-259603-bh198xgl	988	3	mode	mode	NN
cord-259603-bh198xgl	988	4	of	of	IN
cord-259603-bh198xgl	988	5	interaction	interaction	NN
cord-259603-bh198xgl	988	6	between	between	IN
cord-259603-bh198xgl	988	7	the	the	DT
cord-259603-bh198xgl	988	8	nonsense	nonsense	NN
cord-259603-bh198xgl	988	9	-	-	HYPH
cord-259603-bh198xgl	988	10	mediated	mediate	VBN
cord-259603-bh198xgl	988	11	decay	decay	NN
cord-259603-bh198xgl	988	12	factors	factor	NNS
cord-259603-bh198xgl	988	13	,	,	,
cord-259603-bh198xgl	988	14	UPF1	UPF1	NNP
cord-259603-bh198xgl	988	15	and	and	CC
cord-259603-bh198xgl	988	16	UPF2	UPF2	NNP
cord-259603-bh198xgl	989	1	The	the	DT
cord-259603-bh198xgl	989	2	broadspectrum	broadspectrum	NNP
cord-259603-bh198xgl	989	3	antiviral	antiviral	JJ
cord-259603-bh198xgl	989	4	ribonucleoside	ribonucleoside	NN
cord-259603-bh198xgl	989	5	ribavirin	ribavirin	RB
cord-259603-bh198xgl	989	6	is	be	VBZ
cord-259603-bh198xgl	989	7	an	an	DT
cord-259603-bh198xgl	989	8	RNA	RNA	NNP
cord-259603-bh198xgl	989	9	virus	virus	NN
cord-259603-bh198xgl	989	10	mutagen	mutagen	NN
cord-259603-bh198xgl	989	11	Ribavirin	Ribavirin	NNP
cord-259603-bh198xgl	989	12	's	's	POS
cord-259603-bh198xgl	989	13	antiviral	antiviral	JJ
cord-259603-bh198xgl	989	14	mechanism	mechanism	NN
cord-259603-bh198xgl	989	15	of	of	IN
cord-259603-bh198xgl	989	16	action	action	NN
cord-259603-bh198xgl	989	17	:	:	:
cord-259603-bh198xgl	989	18	lethal	lethal	JJ
cord-259603-bh198xgl	989	19	mutagenesis	mutagenesis	NN
cord-259603-bh198xgl	989	20	?	?	.
cord-259603-bh198xgl	989	21	0	0	NFP
cord-259603-bh198xgl	990	1	-O	-O	:
cord-259603-bh198xgl	990	2	methylation	methylation	NN
cord-259603-bh198xgl	990	3	of	of	IN
cord-259603-bh198xgl	990	4	the	the	DT
cord-259603-bh198xgl	990	5	viral	viral	JJ
cord-259603-bh198xgl	990	6	mRNA	mRNA	NNP
cord-259603-bh198xgl	990	7	cap	cap	NN
cord-259603-bh198xgl	990	8	evades	evade	VBZ
cord-259603-bh198xgl	990	9	host	host	NN
cord-259603-bh198xgl	990	10	restriction	restriction	NN
cord-259603-bh198xgl	990	11	by	by	IN
cord-259603-bh198xgl	990	12	IFIT	IFIT	NNP
cord-259603-bh198xgl	990	13	family	family	NN
cord-259603-bh198xgl	990	14	members	member	NNS
cord-259603-bh198xgl	991	1	Family	family	NN
cord-259603-bh198xgl	991	2	Coronaviridae	Coronaviridae	NNP
cord-259603-bh198xgl	991	3	Order	order	NN
cord-259603-bh198xgl	991	4	Nidovirales	Nidovirales	NNP
cord-259603-bh198xgl	991	5	Coronavirus	Coronavirus	NNP
cord-259603-bh198xgl	991	6	nonstructural	nonstructural	JJ
cord-259603-bh198xgl	991	7	protein	protein	NN
cord-259603-bh198xgl	991	8	16	16	CD
cord-259603-bh198xgl	991	9	is	be	VBZ
cord-259603-bh198xgl	991	10	a	a	DT
cord-259603-bh198xgl	991	11	cap-0	cap-0	NN
cord-259603-bh198xgl	991	12	binding	bind	VBG
cord-259603-bh198xgl	991	13	enzyme	enzyme	NN
cord-259603-bh198xgl	991	14	possessing	possess	VBG
cord-259603-bh198xgl	991	15	(	(	-LRB-
cord-259603-bh198xgl	991	16	nucleoside-2	nucleoside-2	NNP
cord-259603-bh198xgl	991	17	0	0	CD
cord-259603-bh198xgl	991	18	O)-methyltransferase	O)-methyltransferase	NNP
cord-259603-bh198xgl	991	19	activity	activity	NN
cord-259603-bh198xgl	991	20	Crystal	Crystal	NNP
cord-259603-bh198xgl	991	21	structure	structure	NN
cord-259603-bh198xgl	991	22	and	and	CC
cord-259603-bh198xgl	991	23	functional	functional	JJ
cord-259603-bh198xgl	991	24	analysis	analysis	NN
cord-259603-bh198xgl	991	25	of	of	IN
cord-259603-bh198xgl	991	26	the	the	DT
cord-259603-bh198xgl	991	27	SARS	SARS	NNP
cord-259603-bh198xgl	991	28	-	-	HYPH
cord-259603-bh198xgl	991	29	coronavirus	coronavirus	NN
cord-259603-bh198xgl	991	30	RNA	RNA	NNP
cord-259603-bh198xgl	991	31	cap	cap	NN
cord-259603-bh198xgl	991	32	2	2	CD
cord-259603-bh198xgl	991	33	0	0	CD
cord-259603-bh198xgl	991	34	-O	-O	:
cord-259603-bh198xgl	991	35	-	-	HYPH
cord-259603-bh198xgl	991	36	methyltransferase	methyltransferase	JJ
cord-259603-bh198xgl	991	37	nsp10	nsp10	NNS
cord-259603-bh198xgl	991	38	/	/	SYM
cord-259603-bh198xgl	991	39	nsp16	nsp16	NNS
cord-259603-bh198xgl	991	40	complex	complex	JJ
cord-259603-bh198xgl	991	41	Conventional	Conventional	NNP
cord-259603-bh198xgl	991	42	and	and	CC
cord-259603-bh198xgl	991	43	unconventional	unconventional	JJ
cord-259603-bh198xgl	991	44	mechanisms	mechanism	NNS
cord-259603-bh198xgl	991	45	for	for	IN
cord-259603-bh198xgl	991	46	capping	cap	VBG
cord-259603-bh198xgl	991	47	viral	viral	JJ
cord-259603-bh198xgl	991	48	mRNA	mrna	NN
cord-259603-bh198xgl	991	49	Processing	processing	NN
cord-259603-bh198xgl	991	50	of	of	IN
cord-259603-bh198xgl	991	51	open	open	JJ
cord-259603-bh198xgl	991	52	reading	reading	NN
cord-259603-bh198xgl	991	53	frame	frame	NN
cord-259603-bh198xgl	991	54	1a	1a	CD
cord-259603-bh198xgl	991	55	replicase	replicase	NNP
cord-259603-bh198xgl	991	56	proteins	protein	NNS
cord-259603-bh198xgl	991	57	nsp7	nsp7	PRP
cord-259603-bh198xgl	991	58	to	to	IN
cord-259603-bh198xgl	991	59	nsp10	nsp10	PRP
cord-259603-bh198xgl	991	60	in	in	IN
cord-259603-bh198xgl	991	61	murine	murine	JJ
cord-259603-bh198xgl	991	62	hepatitis	hepatitis	NN
cord-259603-bh198xgl	991	63	virus	virus	NN
cord-259603-bh198xgl	991	64	strain	strain	NN
cord-259603-bh198xgl	991	65	A59	A59	NNP
cord-259603-bh198xgl	991	66	replication	replication	NN
cord-259603-bh198xgl	991	67	Organelle	Organelle	NNP
cord-259603-bh198xgl	991	68	-	-	HYPH
cord-259603-bh198xgl	991	69	like	like	JJ
cord-259603-bh198xgl	991	70	membrane	membrane	NN
cord-259603-bh198xgl	991	71	compartmentalization	compartmentalization	NN
cord-259603-bh198xgl	991	72	of	of	IN
cord-259603-bh198xgl	991	73	positive	positive	JJ
cord-259603-bh198xgl	991	74	-	-	HYPH
cord-259603-bh198xgl	991	75	strand	strand	NN
cord-259603-bh198xgl	991	76	RNA	RNA	NNP
cord-259603-bh198xgl	991	77	virus	virus	NN
cord-259603-bh198xgl	991	78	replication	replication	NN
cord-259603-bh198xgl	991	79	factories	factory	NNS
cord-259603-bh198xgl	991	80	Structural	structural	JJ
cord-259603-bh198xgl	991	81	basis	basis	NN
cord-259603-bh198xgl	991	82	for	for	IN
cord-259603-bh198xgl	991	83	the	the	DT
cord-259603-bh198xgl	991	84	regulatory	regulatory	JJ
cord-259603-bh198xgl	991	85	function	function	NN
cord-259603-bh198xgl	991	86	of	of	IN
cord-259603-bh198xgl	991	87	a	a	DT
cord-259603-bh198xgl	991	88	complex	complex	JJ
cord-259603-bh198xgl	991	89	zinc	zinc	NN
cord-259603-bh198xgl	991	90	-	-	HYPH
cord-259603-bh198xgl	991	91	binding	bind	VBG
cord-259603-bh198xgl	991	92	domain	domain	NN
cord-259603-bh198xgl	991	93	in	in	IN
cord-259603-bh198xgl	991	94	a	a	DT
cord-259603-bh198xgl	991	95	replicative	replicative	JJ
cord-259603-bh198xgl	991	96	arterivirus	arterivirus	NN
cord-259603-bh198xgl	991	97	helicase	helicase	NN
cord-259603-bh198xgl	991	98	resembling	resemble	VBG
cord-259603-bh198xgl	991	99	a	a	DT
cord-259603-bh198xgl	991	100	nonsense	nonsense	NN
cord-259603-bh198xgl	991	101	-	-	HYPH
cord-259603-bh198xgl	991	102	mediated	mediate	VBN
cord-259603-bh198xgl	991	103	mRNA	mrna	NN
cord-259603-bh198xgl	991	104	decay	decay	NN
cord-259603-bh198xgl	991	105	helicase	helicase	NNP
cord-259603-bh198xgl	992	1	The	the	DT
cord-259603-bh198xgl	992	2	putative	putative	JJ
cord-259603-bh198xgl	992	3	helicase	helicase	NN
cord-259603-bh198xgl	992	4	of	of	IN
cord-259603-bh198xgl	992	5	the	the	DT
cord-259603-bh198xgl	992	6	coronavirus	coronavirus	NN
cord-259603-bh198xgl	992	7	mouse	mouse	NN
cord-259603-bh198xgl	992	8	hepatitis	hepatitis	NN
cord-259603-bh198xgl	992	9	virus	virus	NN
cord-259603-bh198xgl	992	10	is	be	VBZ
cord-259603-bh198xgl	992	11	processed	process	VBN
cord-259603-bh198xgl	992	12	from	from	IN
cord-259603-bh198xgl	992	13	the	the	DT
cord-259603-bh198xgl	992	14	replicase	replicase	NNP
cord-259603-bh198xgl	992	15	gene	gene	NNP
cord-259603-bh198xgl	992	16	polyprotein	polyprotein	NNP
cord-259603-bh198xgl	992	17	and	and	CC
cord-259603-bh198xgl	992	18	localizes	localize	VBZ
cord-259603-bh198xgl	992	19	in	in	IN
cord-259603-bh198xgl	992	20	complexes	complex	NNS
cord-259603-bh198xgl	992	21	that	that	WDT
cord-259603-bh198xgl	992	22	are	be	VBP
cord-259603-bh198xgl	992	23	active	active	JJ
cord-259603-bh198xgl	992	24	in	in	IN
cord-259603-bh198xgl	992	25	viral	viral	JJ
cord-259603-bh198xgl	992	26	RNA	RNA	NNP
cord-259603-bh198xgl	992	27	synthesis	synthesis	NN
cord-259603-bh198xgl	993	1	The	the	DT
cord-259603-bh198xgl	993	2	3	3	CD
cord-259603-bh198xgl	993	3	0	0	CD
cord-259603-bh198xgl	993	4	-5	-5	CD
cord-259603-bh198xgl	993	5	0	0	CD
cord-259603-bh198xgl	993	6	exonuclease	exonuclease	NN
cord-259603-bh198xgl	993	7	of	of	IN
cord-259603-bh198xgl	993	8	DNA	dna	NN
cord-259603-bh198xgl	993	9	polymerase	polymerase	NN
cord-259603-bh198xgl	993	10	I	-PRON-	PRP
cord-259603-bh198xgl	993	11	of	of	IN
cord-259603-bh198xgl	993	12	Escherichia	Escherichia	NNP
cord-259603-bh198xgl	993	13	coli	coli	NNS
cord-259603-bh198xgl	993	14	:	:	:
cord-259603-bh198xgl	993	15	contribution	contribution	NN
cord-259603-bh198xgl	993	16	of	of	IN
cord-259603-bh198xgl	993	17	each	each	DT
cord-259603-bh198xgl	993	18	amino	amino	NN
cord-259603-bh198xgl	993	19	acid	acid	NN
cord-259603-bh198xgl	993	20	at	at	IN
cord-259603-bh198xgl	993	21	the	the	DT
cord-259603-bh198xgl	993	22	active	active	JJ
cord-259603-bh198xgl	993	23	site	site	NN
cord-259603-bh198xgl	993	24	to	to	IN
cord-259603-bh198xgl	993	25	the	the	DT
cord-259603-bh198xgl	993	26	reaction	reaction	NN
cord-259603-bh198xgl	993	27	Structural	structural	JJ
cord-259603-bh198xgl	993	28	basis	basis	NN
cord-259603-bh198xgl	993	29	for	for	IN
cord-259603-bh198xgl	993	30	m7	m7	NN
cord-259603-bh198xgl	993	31	G	g	NN
cord-259603-bh198xgl	993	32	recognition	recognition	NN
cord-259603-bh198xgl	993	33	and	and	CC
cord-259603-bh198xgl	993	34	2	2	CD
cord-259603-bh198xgl	993	35	0	0	CD
cord-259603-bh198xgl	993	36	-O	-O	:
cord-259603-bh198xgl	993	37	-	-	HYPH
cord-259603-bh198xgl	993	38	methyl	methyl	JJ
cord-259603-bh198xgl	993	39	discrimination	discrimination	NN
cord-259603-bh198xgl	993	40	in	in	IN
cord-259603-bh198xgl	993	41	capped	cap	VBN
cord-259603-bh198xgl	993	42	RNAs	rna	NNS
cord-259603-bh198xgl	993	43	by	by	IN
cord-259603-bh198xgl	993	44	the	the	DT
cord-259603-bh198xgl	993	45	innate	innate	JJ
cord-259603-bh198xgl	993	46	immune	immune	JJ
cord-259603-bh198xgl	993	47	receptor	receptor	NN
cord-259603-bh198xgl	993	48	RIG	rig	NN
cord-259603-bh198xgl	993	49	-	-	:
cord-259603-bh198xgl	993	50	I	I	NNP
cord-259603-bh198xgl	993	51	Murine	Murine	NNP
cord-259603-bh198xgl	993	52	hepatitis	hepatitis	NN
cord-259603-bh198xgl	993	53	virus	virus	NN
cord-259603-bh198xgl	993	54	replicase	replicase	NNP
cord-259603-bh198xgl	993	55	protein	protein	NNP
cord-259603-bh198xgl	993	56	nsp10	nsp10	RB
cord-259603-bh198xgl	993	57	is	be	VBZ
cord-259603-bh198xgl	993	58	a	a	DT
cord-259603-bh198xgl	993	59	critical	critical	JJ
cord-259603-bh198xgl	993	60	regulator	regulator	NN
cord-259603-bh198xgl	993	61	of	of	IN
cord-259603-bh198xgl	993	62	viral	viral	JJ
cord-259603-bh198xgl	993	63	RNA	RNA	NNP
cord-259603-bh198xgl	993	64	synthesis	synthesis	NN
cord-259603-bh198xgl	993	65	Mutation	mutation	NN
cord-259603-bh198xgl	993	66	rates	rate	NNS
cord-259603-bh198xgl	993	67	among	among	IN
cord-259603-bh198xgl	993	68	RNA	RNA	NNP
cord-259603-bh198xgl	993	69	viruses	virus	NNS
cord-259603-bh198xgl	993	70	Mutator	Mutator	NNP
cord-259603-bh198xgl	993	71	strains	strain	NNS
cord-259603-bh198xgl	993	72	of	of	IN
cord-259603-bh198xgl	993	73	Escherichia	Escherichia	NNP
cord-259603-bh198xgl	993	74	coli	coli	NNS
cord-259603-bh198xgl	993	75	,	,	,
cord-259603-bh198xgl	993	76	mutD	mutd	NN
cord-259603-bh198xgl	993	77	and	and	CC
cord-259603-bh198xgl	993	78	dnaQ	dnaQ	NNS
cord-259603-bh198xgl	993	79	,	,	,
cord-259603-bh198xgl	993	80	with	with	IN
cord-259603-bh198xgl	993	81	defective	defective	JJ
cord-259603-bh198xgl	993	82	exonucleolytic	exonucleolytic	JJ
cord-259603-bh198xgl	993	83	editing	editing	NN
cord-259603-bh198xgl	993	84	by	by	IN
cord-259603-bh198xgl	993	85	DNA	dna	NN
cord-259603-bh198xgl	993	86	polymerase	polymerase	NN
cord-259603-bh198xgl	993	87	III	iii	CD
cord-259603-bh198xgl	993	88	holoenzyme	holoenzyme	NNS
cord-259603-bh198xgl	993	89	High	high	JJ
cord-259603-bh198xgl	993	90	fidelity	fidelity	NN
cord-259603-bh198xgl	993	91	of	of	IN
cord-259603-bh198xgl	993	92	murine	murine	JJ
cord-259603-bh198xgl	993	93	hepatitis	hepatitis	NN
cord-259603-bh198xgl	993	94	virus	virus	NN
cord-259603-bh198xgl	993	95	replication	replication	NN
cord-259603-bh198xgl	993	96	is	be	VBZ
cord-259603-bh198xgl	993	97	decreased	decrease	VBN
cord-259603-bh198xgl	993	98	in	in	IN
cord-259603-bh198xgl	993	99	nsp14	nsp14	CD
cord-259603-bh198xgl	993	100	exoribonuclease	exoribonuclease	NN
cord-259603-bh198xgl	993	101	mutants	mutant	NNS
cord-259603-bh198xgl	993	102	Infidelity	Infidelity	NNP
cord-259603-bh198xgl	993	103	of	of	IN
cord-259603-bh198xgl	993	104	SARS	SARS	NNP
cord-259603-bh198xgl	993	105	-	-	HYPH
cord-259603-bh198xgl	993	106	CoV	CoV	NNP
cord-259603-bh198xgl	993	107	Nsp14-exonuclease	Nsp14-exonuclease	NNP
cord-259603-bh198xgl	993	108	mutant	mutant	JJ
cord-259603-bh198xgl	993	109	virus	virus	NN
cord-259603-bh198xgl	993	110	replication	replication	NN
cord-259603-bh198xgl	993	111	is	be	VBZ
cord-259603-bh198xgl	993	112	revealed	reveal	VBN
cord-259603-bh198xgl	993	113	by	by	IN
cord-259603-bh198xgl	993	114	complete	complete	JJ
cord-259603-bh198xgl	993	115	genome	genome	NN
cord-259603-bh198xgl	993	116	sequencing	sequencing	NN
cord-259603-bh198xgl	994	1	The	the	DT
cord-259603-bh198xgl	994	2	severe	severe	JJ
cord-259603-bh198xgl	994	3	acute	acute	JJ
cord-259603-bh198xgl	994	4	respiratory	respiratory	JJ
cord-259603-bh198xgl	994	5	syndrome	syndrome	NN
cord-259603-bh198xgl	994	6	-	-	HYPH
cord-259603-bh198xgl	994	7	coronavirus	coronavirus	NN
cord-259603-bh198xgl	994	8	replicative	replicative	JJ
cord-259603-bh198xgl	994	9	protein	protein	NN
cord-259603-bh198xgl	994	10	nsp9	nsp9	NN
cord-259603-bh198xgl	994	11	is	be	VBZ
cord-259603-bh198xgl	994	12	a	a	DT
cord-259603-bh198xgl	994	13	single	single	RB
cord-259603-bh198xgl	994	14	-	-	HYPH
cord-259603-bh198xgl	994	15	stranded	strand	VBN
cord-259603-bh198xgl	994	16	RNA	rna	NN
cord-259603-bh198xgl	994	17	-	-	HYPH
cord-259603-bh198xgl	994	18	binding	bind	VBG
cord-259603-bh198xgl	994	19	subunit	subunit	NN
cord-259603-bh198xgl	994	20	unique	unique	JJ
cord-259603-bh198xgl	994	21	in	in	IN
cord-259603-bh198xgl	994	22	the	the	DT
cord-259603-bh198xgl	994	23	RNA	RNA	NNP
cord-259603-bh198xgl	994	24	virus	virus	NN
cord-259603-bh198xgl	994	25	world	world	NN
cord-259603-bh198xgl	994	26	Treatment	Treatment	NNP
cord-259603-bh198xgl	994	27	with	with	IN
cord-259603-bh198xgl	994	28	interferon	interferon	NN
cord-259603-bh198xgl	994	29	-	-	HYPH
cord-259603-bh198xgl	994	30	alpha2b	alpha2b	NNP
cord-259603-bh198xgl	994	31	and	and	CC
cord-259603-bh198xgl	994	32	ribavirin	ribavirin	NNP
cord-259603-bh198xgl	994	33	improves	improve	VBZ
cord-259603-bh198xgl	994	34	outcome	outcome	NN
cord-259603-bh198xgl	994	35	in	in	IN
cord-259603-bh198xgl	994	36	MERS	MERS	NNP
cord-259603-bh198xgl	994	37	-	-	HYPH
cord-259603-bh198xgl	994	38	CoV	CoV	NNP
cord-259603-bh198xgl	994	39	-	-	HYPH
cord-259603-bh198xgl	994	40	infected	infect	VBN
cord-259603-bh198xgl	994	41	rhesus	rhesu	NNS
cord-259603-bh198xgl	994	42	macaques	macaque	NNS
cord-259603-bh198xgl	995	1	An	an	DT
cord-259603-bh198xgl	995	2	arginine	arginine	NN
cord-259603-bh198xgl	995	3	-	-	HYPH
cord-259603-bh198xgl	995	4	to	to	IN
cord-259603-bh198xgl	995	5	-	-	HYPH
cord-259603-bh198xgl	995	6	proline	proline	NN
cord-259603-bh198xgl	995	7	mutation	mutation	NN
cord-259603-bh198xgl	995	8	in	in	IN
cord-259603-bh198xgl	995	9	a	a	DT
cord-259603-bh198xgl	995	10	domain	domain	NN
cord-259603-bh198xgl	995	11	with	with	IN
cord-259603-bh198xgl	995	12	undefined	undefined	JJ
cord-259603-bh198xgl	995	13	functions	function	NNS
cord-259603-bh198xgl	995	14	within	within	IN
cord-259603-bh198xgl	995	15	the	the	DT
cord-259603-bh198xgl	995	16	helicase	helicase	NN
cord-259603-bh198xgl	995	17	protein	protein	NN
cord-259603-bh198xgl	995	18	(	(	-LRB-
cord-259603-bh198xgl	995	19	Nsp13	Nsp13	NNP
cord-259603-bh198xgl	995	20	)	)	-RRB-
cord-259603-bh198xgl	995	21	is	be	VBZ
cord-259603-bh198xgl	995	22	lethal	lethal	JJ
cord-259603-bh198xgl	995	23	to	to	IN
cord-259603-bh198xgl	995	24	the	the	DT
cord-259603-bh198xgl	995	25	coronavirus	coronavirus	NN
cord-259603-bh198xgl	995	26	infectious	infectious	JJ
cord-259603-bh198xgl	995	27	bronchitis	bronchitis	NN
cord-259603-bh198xgl	995	28	virus	virus	NN
cord-259603-bh198xgl	995	29	in	in	IN
cord-259603-bh198xgl	995	30	cultured	cultured	JJ
cord-259603-bh198xgl	995	31	cells	cell	NNS
cord-259603-bh198xgl	995	32	Proteolytic	proteolytic	JJ
cord-259603-bh198xgl	995	33	processing	processing	NN
cord-259603-bh198xgl	995	34	of	of	IN
cord-259603-bh198xgl	995	35	polyproteins	polyproteins	NNP
cord-259603-bh198xgl	995	36	1a	1a	NNP
cord-259603-bh198xgl	995	37	and	and	CC
cord-259603-bh198xgl	995	38	1ab	1ab	CD
cord-259603-bh198xgl	995	39	between	between	IN
cord-259603-bh198xgl	995	40	non	non	JJ
cord-259603-bh198xgl	995	41	-	-	JJ
cord-259603-bh198xgl	995	42	structural	structural	JJ
cord-259603-bh198xgl	995	43	proteins	protein	NNS
cord-259603-bh198xgl	995	44	10	10	CD
cord-259603-bh198xgl	995	45	and	and	CC
cord-259603-bh198xgl	995	46	11/12	11/12	CD
cord-259603-bh198xgl	995	47	of	of	IN
cord-259603-bh198xgl	995	48	coronavirus	coronavirus	NN
cord-259603-bh198xgl	995	49	infectious	infectious	JJ
cord-259603-bh198xgl	995	50	bronchitis	bronchitis	NN
cord-259603-bh198xgl	995	51	virus	virus	NN
cord-259603-bh198xgl	995	52	is	be	VBZ
cord-259603-bh198xgl	995	53	dispensable	dispensable	JJ
cord-259603-bh198xgl	995	54	for	for	IN
cord-259603-bh198xgl	995	55	viral	viral	JJ
cord-259603-bh198xgl	995	56	replication	replication	NN
cord-259603-bh198xgl	995	57	in	in	IN
cord-259603-bh198xgl	995	58	cultured	cultured	JJ
cord-259603-bh198xgl	995	59	cells	cell	NNS
cord-259603-bh198xgl	995	60	Molecular	molecular	JJ
cord-259603-bh198xgl	995	61	phylogenetics	phylogenetic	NNS
cord-259603-bh198xgl	995	62	of	of	IN
cord-259603-bh198xgl	995	63	the	the	DT
cord-259603-bh198xgl	995	64	RrmJ	RrmJ	NNP
cord-259603-bh198xgl	995	65	/	/	SYM
cord-259603-bh198xgl	995	66	fibrillarin	fibrillarin	NNP
cord-259603-bh198xgl	995	67	superfamily	superfamily	NN
cord-259603-bh198xgl	995	68	of	of	IN
cord-259603-bh198xgl	995	69	ribose	ribose	NN
cord-259603-bh198xgl	995	70	2	2	CD
cord-259603-bh198xgl	995	71	0	0	CD
cord-259603-bh198xgl	995	72	-O	-o	CD
cord-259603-bh198xgl	995	73	-	-	HYPH
cord-259603-bh198xgl	995	74	methyltransferases	methyltransferase	NNS
cord-259603-bh198xgl	996	1	The	the	DT
cord-259603-bh198xgl	996	2	viral	viral	JJ
cord-259603-bh198xgl	996	3	RNA	rna	NN
cord-259603-bh198xgl	996	4	capping	cap	VBG
cord-259603-bh198xgl	996	5	machinery	machinery	NN
cord-259603-bh198xgl	996	6	as	as	IN
cord-259603-bh198xgl	996	7	a	a	DT
cord-259603-bh198xgl	996	8	target	target	NN
cord-259603-bh198xgl	996	9	for	for	IN
cord-259603-bh198xgl	996	10	antiviral	antiviral	JJ
cord-259603-bh198xgl	996	11	drugs	drug	NNS
cord-259603-bh198xgl	997	1	A	a	DT
cord-259603-bh198xgl	997	2	protein	protein	NN
cord-259603-bh198xgl	997	3	binding	bind	VBG
cord-259603-bh198xgl	997	4	the	the	DT
cord-259603-bh198xgl	997	5	methylated	methylate	VBN
cord-259603-bh198xgl	997	6	5	5	CD
cord-259603-bh198xgl	997	7	0	0	CD
cord-259603-bh198xgl	997	8	-terminal	-terminal	JJ
cord-259603-bh198xgl	997	9	sequence	sequence	NN
cord-259603-bh198xgl	997	10	,	,	,
cord-259603-bh198xgl	997	11	m7GpppN	m7GpppN	NNS
cord-259603-bh198xgl	997	12	,	,	,
cord-259603-bh198xgl	997	13	of	of	IN
cord-259603-bh198xgl	997	14	eukaryotic	eukaryotic	JJ
cord-259603-bh198xgl	997	15	messenger	messenger	NN
cord-259603-bh198xgl	997	16	RNA	RNA	NNP
cord-259603-bh198xgl	997	17	Molecular	Molecular	NNP
cord-259603-bh198xgl	997	18	determinants	determinant	NNS
cord-259603-bh198xgl	997	19	of	of	IN
cord-259603-bh198xgl	997	20	severe	severe	JJ
cord-259603-bh198xgl	997	21	acute	acute	JJ
cord-259603-bh198xgl	997	22	respiratory	respiratory	JJ
cord-259603-bh198xgl	997	23	syndrome	syndrome	NN
cord-259603-bh198xgl	997	24	coronavirus	coronavirus	NN
cord-259603-bh198xgl	997	25	pathogenesis	pathogenesis	NN
cord-259603-bh198xgl	997	26	and	and	CC
cord-259603-bh198xgl	997	27	virulence	virulence	NN
cord-259603-bh198xgl	997	28	in	in	IN
cord-259603-bh198xgl	997	29	young	young	JJ
cord-259603-bh198xgl	997	30	and	and	CC
cord-259603-bh198xgl	997	31	aged	aged	JJ
cord-259603-bh198xgl	997	32	mouse	mouse	NN
cord-259603-bh198xgl	997	33	models	model	NNS
cord-259603-bh198xgl	997	34	of	of	IN
cord-259603-bh198xgl	997	35	human	human	JJ
cord-259603-bh198xgl	997	36	disease	disease	NN
cord-259603-bh198xgl	997	37	Isolation	isolation	NN
cord-259603-bh198xgl	997	38	and	and	CC
cord-259603-bh198xgl	997	39	characterization	characterization	NN
cord-259603-bh198xgl	997	40	of	of	IN
cord-259603-bh198xgl	997	41	a	a	DT
cord-259603-bh198xgl	997	42	bat	bat	NN
cord-259603-bh198xgl	997	43	SARS	SARS	NNP
cord-259603-bh198xgl	997	44	-	-	HYPH
cord-259603-bh198xgl	997	45	like	like	JJ
cord-259603-bh198xgl	997	46	coronavirus	coronavirus	NN
cord-259603-bh198xgl	997	47	that	that	WDT
cord-259603-bh198xgl	997	48	uses	use	VBZ
cord-259603-bh198xgl	997	49	the	the	DT
cord-259603-bh198xgl	997	50	ACE2	ACE2	NNP
cord-259603-bh198xgl	997	51	receptor	receptor	NN
cord-259603-bh198xgl	997	52	Functional	functional	JJ
cord-259603-bh198xgl	997	53	characterization	characterization	NN
cord-259603-bh198xgl	997	54	of	of	IN
cord-259603-bh198xgl	997	55	XendoU	xendou	NN
cord-259603-bh198xgl	997	56	,	,	,
cord-259603-bh198xgl	997	57	the	the	DT
cord-259603-bh198xgl	997	58	endoribonuclease	endoribonuclease	NN
cord-259603-bh198xgl	997	59	involved	involve	VBN
cord-259603-bh198xgl	997	60	in	in	IN
cord-259603-bh198xgl	997	61	small	small	JJ
cord-259603-bh198xgl	997	62	nucleolar	nucleolar	NNS
cord-259603-bh198xgl	997	63	RNA	RNA	NNP
cord-259603-bh198xgl	997	64	biosynthesis	biosynthesis	NN
cord-259603-bh198xgl	997	65	Big	big	JJ
cord-259603-bh198xgl	997	66	nidovirus	nidovirus	NN
cord-259603-bh198xgl	997	67	genome	genome	NN
cord-259603-bh198xgl	997	68	.	.	.
cord-259603-bh198xgl	998	1	When	when	WRB
cord-259603-bh198xgl	998	2	count	count	NN
cord-259603-bh198xgl	998	3	and	and	CC
cord-259603-bh198xgl	998	4	order	order	NN
cord-259603-bh198xgl	998	5	of	of	IN
cord-259603-bh198xgl	998	6	domains	domain	NNS
cord-259603-bh198xgl	998	7	matter	matter	VBP
cord-259603-bh198xgl	998	8	Coronavirus	Coronavirus	NNP
cord-259603-bh198xgl	998	9	genome	genome	NN
cord-259603-bh198xgl	998	10	:	:	:
cord-259603-bh198xgl	998	11	prediction	prediction	NN
cord-259603-bh198xgl	998	12	of	of	IN
cord-259603-bh198xgl	998	13	putative	putative	JJ
cord-259603-bh198xgl	998	14	functional	functional	JJ
cord-259603-bh198xgl	998	15	domains	domain	NNS
cord-259603-bh198xgl	998	16	in	in	IN
cord-259603-bh198xgl	998	17	the	the	DT
cord-259603-bh198xgl	998	18	non	non	JJ
cord-259603-bh198xgl	998	19	-	-	JJ
cord-259603-bh198xgl	998	20	structural	structural	JJ
cord-259603-bh198xgl	998	21	polyprotein	polyprotein	NN
cord-259603-bh198xgl	998	22	by	by	IN
cord-259603-bh198xgl	998	23	comparative	comparative	JJ
cord-259603-bh198xgl	998	24	amino	amino	NN
cord-259603-bh198xgl	998	25	acid	acid	NN
cord-259603-bh198xgl	998	26	sequence	sequence	NN
cord-259603-bh198xgl	998	27	analysis	analysis	NN
cord-259603-bh198xgl	999	1	The	the	DT
cord-259603-bh198xgl	999	2	palm	palm	NN
cord-259603-bh198xgl	999	3	subdomain	subdomain	NN
cord-259603-bh198xgl	999	4	-	-	HYPH
cord-259603-bh198xgl	999	5	based	base	VBN
cord-259603-bh198xgl	999	6	active	active	JJ
cord-259603-bh198xgl	999	7	site	site	NN
cord-259603-bh198xgl	999	8	is	be	VBZ
cord-259603-bh198xgl	999	9	internally	internally	RB
cord-259603-bh198xgl	999	10	permuted	permute	VBN
cord-259603-bh198xgl	999	11	in	in	IN
cord-259603-bh198xgl	999	12	viral	viral	JJ
cord-259603-bh198xgl	999	13	RNAdependent	RNAdependent	NNP
cord-259603-bh198xgl	999	14	RNA	RNA	NNP
cord-259603-bh198xgl	999	15	polymerases	polymerase	NNS
cord-259603-bh198xgl	999	16	of	of	IN
cord-259603-bh198xgl	999	17	an	an	DT
cord-259603-bh198xgl	999	18	ancient	ancient	JJ
cord-259603-bh198xgl	999	19	lineage	lineage	NN
cord-259603-bh198xgl	999	20	Nidovirales	Nidovirales	NNP
cord-259603-bh198xgl	999	21	:	:	:
cord-259603-bh198xgl	999	22	evolving	evolve	VBG
cord-259603-bh198xgl	999	23	the	the	DT
cord-259603-bh198xgl	999	24	largest	large	JJS
cord-259603-bh198xgl	999	25	RNA	RNA	NNP
cord-259603-bh198xgl	999	26	virus	virus	NN
cord-259603-bh198xgl	999	27	genome	genome	NN
cord-259603-bh198xgl	999	28	RNA	RNA	NNP
cord-259603-bh198xgl	999	29	replication	replication	NN
cord-259603-bh198xgl	999	30	of	of	IN
cord-259603-bh198xgl	999	31	mouse	mouse	NN
cord-259603-bh198xgl	999	32	hepatitis	hepatitis	NNP
cord-259603-bh198xgl	999	33	virus	virus	NN
cord-259603-bh198xgl	999	34	takes	take	VBZ
cord-259603-bh198xgl	999	35	place	place	NN
cord-259603-bh198xgl	999	36	at	at	IN
cord-259603-bh198xgl	999	37	double	double	JJ
cord-259603-bh198xgl	999	38	-	-	HYPH
cord-259603-bh198xgl	999	39	membrane	membrane	NN
cord-259603-bh198xgl	999	40	vesicles	vesicle	NNS
cord-259603-bh198xgl	999	41	Recombination	recombination	NN
cord-259603-bh198xgl	999	42	,	,	,
cord-259603-bh198xgl	999	43	reservoirs	reservoir	NNS
cord-259603-bh198xgl	999	44	,	,	,
cord-259603-bh198xgl	999	45	and	and	CC
cord-259603-bh198xgl	999	46	the	the	DT
cord-259603-bh198xgl	999	47	modular	modular	JJ
cord-259603-bh198xgl	999	48	spike	spike	NN
cord-259603-bh198xgl	999	49	:	:	:
cord-259603-bh198xgl	999	50	mechanisms	mechanism	NNS
cord-259603-bh198xgl	999	51	of	of	IN
cord-259603-bh198xgl	999	52	coronavirus	coronavirus	NN
cord-259603-bh198xgl	999	53	cross	cross	JJ
cord-259603-bh198xgl	999	54	-	-	JJ
cord-259603-bh198xgl	999	55	species	species	JJ
cord-259603-bh198xgl	999	56	transmission	transmission	NN
cord-259603-bh198xgl	1000	1	A	a	DT
cord-259603-bh198xgl	1000	2	live	live	JJ
cord-259603-bh198xgl	1000	3	,	,	,
cord-259603-bh198xgl	1000	4	impaired	impair	VBN
cord-259603-bh198xgl	1000	5	-	-	HYPH
cord-259603-bh198xgl	1000	6	fidelity	fidelity	NN
cord-259603-bh198xgl	1000	7	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1000	8	vaccine	vaccine	NN
cord-259603-bh198xgl	1000	9	protects	protect	VBZ
cord-259603-bh198xgl	1000	10	in	in	IN
cord-259603-bh198xgl	1000	11	an	an	DT
cord-259603-bh198xgl	1000	12	aged	aged	JJ
cord-259603-bh198xgl	1000	13	,	,	,
cord-259603-bh198xgl	1000	14	immunocompromised	immunocompromised	JJ
cord-259603-bh198xgl	1000	15	mouse	mouse	NN
cord-259603-bh198xgl	1000	16	model	model	NN
cord-259603-bh198xgl	1000	17	of	of	IN
cord-259603-bh198xgl	1000	18	lethal	lethal	JJ
cord-259603-bh198xgl	1000	19	disease	disease	NN
cord-259603-bh198xgl	1001	1	A	a	DT
cord-259603-bh198xgl	1001	2	decade	decade	NN
cord-259603-bh198xgl	1001	3	after	after	IN
cord-259603-bh198xgl	1001	4	SARS	SARS	NNP
cord-259603-bh198xgl	1001	5	:	:	:
cord-259603-bh198xgl	1001	6	strategies	strategy	NNS
cord-259603-bh198xgl	1001	7	for	for	IN
cord-259603-bh198xgl	1001	8	controlling	control	VBG
cord-259603-bh198xgl	1001	9	emerging	emerge	VBG
cord-259603-bh198xgl	1001	10	coronaviruses	coronaviruse	NNS
cord-259603-bh198xgl	1002	1	Mutational	mutational	JJ
cord-259603-bh198xgl	1002	2	analysis	analysis	NN
cord-259603-bh198xgl	1002	3	of	of	IN
cord-259603-bh198xgl	1002	4	the	the	DT
cord-259603-bh198xgl	1002	5	SARS	SARS	NNP
cord-259603-bh198xgl	1002	6	virus	virus	NN
cord-259603-bh198xgl	1003	1	Nsp15	Nsp15	NNP
cord-259603-bh198xgl	1003	2	endoribonuclease	endoribonuclease	NN
cord-259603-bh198xgl	1003	3	:	:	:
cord-259603-bh198xgl	1003	4	identification	identification	NN
cord-259603-bh198xgl	1003	5	of	of	IN
cord-259603-bh198xgl	1003	6	residues	residue	NNS
cord-259603-bh198xgl	1003	7	affecting	affect	VBG
cord-259603-bh198xgl	1003	8	hexamer	hexamer	NN
cord-259603-bh198xgl	1003	9	formation	formation	NN
cord-259603-bh198xgl	1003	10	Sequestration	sequestration	NN
cord-259603-bh198xgl	1003	11	by	by	IN
cord-259603-bh198xgl	1003	12	IFIT1	ifit1	JJ
cord-259603-bh198xgl	1003	13	impairs	impair	VBZ
cord-259603-bh198xgl	1003	14	translation	translation	NN
cord-259603-bh198xgl	1003	15	of	of	IN
cord-259603-bh198xgl	1003	16	2	2	CD
cord-259603-bh198xgl	1003	17	0	0	CD
cord-259603-bh198xgl	1003	18	O	o	NN
cord-259603-bh198xgl	1003	19	-	-	HYPH
cord-259603-bh198xgl	1003	20	unmethylated	unmethylate	VBN
cord-259603-bh198xgl	1003	21	capped	cap	VBN
cord-259603-bh198xgl	1003	22	RNA	RNA	NNP
cord-259603-bh198xgl	1003	23	Biogenesis	Biogenesis	NNP
cord-259603-bh198xgl	1003	24	and	and	CC
cord-259603-bh198xgl	1003	25	dynamics	dynamic	NNS
cord-259603-bh198xgl	1003	26	of	of	IN
cord-259603-bh198xgl	1003	27	the	the	DT
cord-259603-bh198xgl	1003	28	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1003	29	replicative	replicative	JJ
cord-259603-bh198xgl	1003	30	structures	structure	NNS
cord-259603-bh198xgl	1003	31	Membrane	membrane	NN
cord-259603-bh198xgl	1003	32	rearrangements	rearrangement	NNS
cord-259603-bh198xgl	1003	33	mediated	mediate	VBN
cord-259603-bh198xgl	1003	34	by	by	IN
cord-259603-bh198xgl	1003	35	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1003	36	nonstructural	nonstructural	JJ
cord-259603-bh198xgl	1003	37	proteins	protein	NNS
cord-259603-bh198xgl	1003	38	3	3	CD
cord-259603-bh198xgl	1003	39	and	and	CC
cord-259603-bh198xgl	1003	40	4	4	CD
cord-259603-bh198xgl	1003	41	.	.	.
cord-259603-bh198xgl	1004	1	Virology	virology	NN
cord-259603-bh198xgl	1004	2	458	458	CD
cord-259603-bh198xgl	1004	3	-	-	SYM
cord-259603-bh198xgl	1004	4	459	459	CD
cord-259603-bh198xgl	1004	5	Structural	structural	JJ
cord-259603-bh198xgl	1004	6	basis	basis	NN
cord-259603-bh198xgl	1004	7	for	for	IN
cord-259603-bh198xgl	1004	8	proofreading	proofread	VBG
cord-259603-bh198xgl	1004	9	during	during	IN
cord-259603-bh198xgl	1004	10	replication	replication	NN
cord-259603-bh198xgl	1004	11	of	of	IN
cord-259603-bh198xgl	1004	12	the	the	DT
cord-259603-bh198xgl	1004	13	Escherichia	Escherichia	NNP
cord-259603-bh198xgl	1004	14	coli	coli	NNS
cord-259603-bh198xgl	1004	15	chromosome	chromosome	NN
cord-259603-bh198xgl	1004	16	Potent	potent	JJ
cord-259603-bh198xgl	1004	17	and	and	CC
cord-259603-bh198xgl	1004	18	selective	selective	JJ
cord-259603-bh198xgl	1004	19	inhibition	inhibition	NN
cord-259603-bh198xgl	1004	20	of	of	IN
cord-259603-bh198xgl	1004	21	SARS	SARS	NNP
cord-259603-bh198xgl	1004	22	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1004	23	replication	replication	NN
cord-259603-bh198xgl	1004	24	by	by	IN
cord-259603-bh198xgl	1004	25	aurintricarboxylic	aurintricarboxylic	JJ
cord-259603-bh198xgl	1004	26	acid	acid	NN
cord-259603-bh198xgl	1004	27	From	from	IN
cord-259603-bh198xgl	1004	28	SARS	SARS	NNP
cord-259603-bh198xgl	1004	29	to	to	IN
cord-259603-bh198xgl	1004	30	MERS	MERS	NNP
cord-259603-bh198xgl	1004	31	:	:	:
cord-259603-bh198xgl	1004	32	crystallographic	crystallographic	JJ
cord-259603-bh198xgl	1004	33	studies	study	NNS
cord-259603-bh198xgl	1004	34	on	on	IN
cord-259603-bh198xgl	1004	35	coronaviral	coronaviral	JJ
cord-259603-bh198xgl	1004	36	proteases	protease	NNS
cord-259603-bh198xgl	1004	37	enable	enable	VBP
cord-259603-bh198xgl	1004	38	antiviral	antiviral	JJ
cord-259603-bh198xgl	1004	39	drug	drug	NN
cord-259603-bh198xgl	1004	40	design	design	NN
cord-259603-bh198xgl	1004	41	Three	three	CD
cord-259603-bh198xgl	1004	42	dimensional	dimensional	JJ
cord-259603-bh198xgl	1004	43	model	model	NN
cord-259603-bh198xgl	1004	44	of	of	IN
cord-259603-bh198xgl	1004	45	severe	severe	JJ
cord-259603-bh198xgl	1004	46	acute	acute	JJ
cord-259603-bh198xgl	1004	47	respiratory	respiratory	JJ
cord-259603-bh198xgl	1004	48	syndrome	syndrome	NN
cord-259603-bh198xgl	1004	49	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1004	50	helicase	helicase	VBD
cord-259603-bh198xgl	1004	51	ATPase	ATPase	NNP
cord-259603-bh198xgl	1004	52	catalytic	catalytic	JJ
cord-259603-bh198xgl	1004	53	domain	domain	NN
cord-259603-bh198xgl	1004	54	and	and	CC
cord-259603-bh198xgl	1004	55	molecular	molecular	JJ
cord-259603-bh198xgl	1004	56	design	design	NN
cord-259603-bh198xgl	1004	57	of	of	IN
cord-259603-bh198xgl	1004	58	severe	severe	JJ
cord-259603-bh198xgl	1004	59	acute	acute	JJ
cord-259603-bh198xgl	1004	60	respiratory	respiratory	JJ
cord-259603-bh198xgl	1004	61	syndrome	syndrome	NN
cord-259603-bh198xgl	1004	62	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1004	63	helicase	helicase	NN
cord-259603-bh198xgl	1004	64	inhibitors	inhibitor	NNS
cord-259603-bh198xgl	1005	1	Innate	innate	JJ
cord-259603-bh198xgl	1005	2	immune	immune	JJ
cord-259603-bh198xgl	1005	3	restriction	restriction	NN
cord-259603-bh198xgl	1005	4	and	and	CC
cord-259603-bh198xgl	1005	5	antagonism	antagonism	NN
cord-259603-bh198xgl	1005	6	of	of	IN
cord-259603-bh198xgl	1005	7	viral	viral	JJ
cord-259603-bh198xgl	1005	8	RNA	RNA	NNP
cord-259603-bh198xgl	1005	9	lacking	lack	VBG
cord-259603-bh198xgl	1005	10	2-O	2-o	CD
cord-259603-bh198xgl	1005	11	methylation	methylation	NN
cord-259603-bh198xgl	1006	1	A	a	DT
cord-259603-bh198xgl	1006	2	viral	viral	JJ
cord-259603-bh198xgl	1006	3	RNA	RNA	NNP
cord-259603-bh198xgl	1006	4	structural	structural	JJ
cord-259603-bh198xgl	1006	5	element	element	NN
cord-259603-bh198xgl	1006	6	alters	alter	VBZ
cord-259603-bh198xgl	1006	7	host	host	NN
cord-259603-bh198xgl	1006	8	recognition	recognition	NN
cord-259603-bh198xgl	1006	9	of	of	IN
cord-259603-bh198xgl	1006	10	nonself	nonself	NNP
cord-259603-bh198xgl	1006	11	RNA	RNA	NNP
cord-259603-bh198xgl	1006	12	Synthesis	Synthesis	NNP
cord-259603-bh198xgl	1006	13	and	and	CC
cord-259603-bh198xgl	1006	14	biological	biological	JJ
cord-259603-bh198xgl	1006	15	evaluation	evaluation	NN
cord-259603-bh198xgl	1006	16	of	of	IN
cord-259603-bh198xgl	1006	17	nucleoside	nucleoside	JJ
cord-259603-bh198xgl	1006	18	analogues	analogue	NNS
cord-259603-bh198xgl	1006	19	having	have	VBG
cord-259603-bh198xgl	1006	20	6-chloropurine	6-chloropurine	CD
cord-259603-bh198xgl	1006	21	as	as	IN
cord-259603-bh198xgl	1006	22	anti	anti	JJ
cord-259603-bh198xgl	1006	23	-	-	JJ
cord-259603-bh198xgl	1006	24	SARS	SARS	NNP
cord-259603-bh198xgl	1006	25	-	-	HYPH
cord-259603-bh198xgl	1006	26	CoV	CoV	NNP
cord-259603-bh198xgl	1006	27	agents	agent	NNS
cord-259603-bh198xgl	1007	1	A	a	DT
cord-259603-bh198xgl	1007	2	second	second	JJ
cord-259603-bh198xgl	1007	3	,	,	,
cord-259603-bh198xgl	1007	4	non	non	JJ
cord-259603-bh198xgl	1007	5	-	-	JJ
cord-259603-bh198xgl	1007	6	canonical	canonical	JJ
cord-259603-bh198xgl	1007	7	RNA	rna	NN
cord-259603-bh198xgl	1007	8	-	-	HYPH
cord-259603-bh198xgl	1007	9	dependent	dependent	JJ
cord-259603-bh198xgl	1007	10	RNA	RNA	NNP
cord-259603-bh198xgl	1007	11	polymerase	polymerase	NN
cord-259603-bh198xgl	1007	12	in	in	IN
cord-259603-bh198xgl	1007	13	SARS	SARS	NNP
cord-259603-bh198xgl	1007	14	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1008	1	The	the	DT
cord-259603-bh198xgl	1008	2	SARS	SARS	NNP
cord-259603-bh198xgl	1008	3	-	-	HYPH
cord-259603-bh198xgl	1008	4	Coronavirus	Coronavirus	NNP
cord-259603-bh198xgl	1008	5	PLnc	PLnc	NNP
cord-259603-bh198xgl	1008	6	domain	domain	NN
cord-259603-bh198xgl	1008	7	of	of	IN
cord-259603-bh198xgl	1008	8	nsp3	nsp3	NNS
cord-259603-bh198xgl	1008	9	as	as	IN
cord-259603-bh198xgl	1008	10	a	a	DT
cord-259603-bh198xgl	1008	11	replication	replication	NN
cord-259603-bh198xgl	1008	12	/	/	SYM
cord-259603-bh198xgl	1008	13	transcription	transcription	NN
cord-259603-bh198xgl	1008	14	scaffolding	scaffold	VBG
cord-259603-bh198xgl	1008	15	protein	protein	NN
cord-259603-bh198xgl	1008	16	Highresolution	Highresolution	NNP
cord-259603-bh198xgl	1008	17	analysis	analysis	NN
cord-259603-bh198xgl	1008	18	of	of	IN
cord-259603-bh198xgl	1008	19	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1008	20	gene	gene	NN
cord-259603-bh198xgl	1008	21	expression	expression	NN
cord-259603-bh198xgl	1008	22	by	by	IN
cord-259603-bh198xgl	1008	23	RNA	RNA	NNP
cord-259603-bh198xgl	1008	24	sequencing	sequencing	NN
cord-259603-bh198xgl	1008	25	and	and	CC
cord-259603-bh198xgl	1008	26	ribosome	ribosome	NN
cord-259603-bh198xgl	1008	27	profiling	profile	VBG
cord-259603-bh198xgl	1008	28	Human	human	JJ
cord-259603-bh198xgl	1008	29	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1008	30	229E	229e	CD
cord-259603-bh198xgl	1008	31	nonstructural	nonstructural	JJ
cord-259603-bh198xgl	1008	32	protein	protein	NNP
cord-259603-bh198xgl	1008	33	13	13	CD
cord-259603-bh198xgl	1008	34	:	:	:
cord-259603-bh198xgl	1008	35	characterization	characterization	NN
cord-259603-bh198xgl	1008	36	of	of	IN
cord-259603-bh198xgl	1008	37	duplex	duplex	NN
cord-259603-bh198xgl	1008	38	-	-	HYPH
cord-259603-bh198xgl	1008	39	unwinding	unwinding	NN
cord-259603-bh198xgl	1008	40	,	,	,
cord-259603-bh198xgl	1008	41	nucleoside	nucleoside	RB
cord-259603-bh198xgl	1008	42	triphosphatase	triphosphatase	NN
cord-259603-bh198xgl	1008	43	,	,	,
cord-259603-bh198xgl	1008	44	and	and	CC
cord-259603-bh198xgl	1008	45	RNA	RNA	NNP
cord-259603-bh198xgl	1008	46	5	5	CD
cord-259603-bh198xgl	1008	47	0	0	CD
cord-259603-bh198xgl	1009	1	-triphosphatase	-triphosphatase	:
cord-259603-bh198xgl	1009	2	activities	activity	NNS
cord-259603-bh198xgl	1010	1	Major	major	JJ
cord-259603-bh198xgl	1010	2	genetic	genetic	JJ
cord-259603-bh198xgl	1010	3	marker	marker	NN
cord-259603-bh198xgl	1010	4	of	of	IN
cord-259603-bh198xgl	1010	5	nidoviruses	nidoviruses	NNP
cord-259603-bh198xgl	1010	6	encodes	encode	VBZ
cord-259603-bh198xgl	1010	7	a	a	DT
cord-259603-bh198xgl	1010	8	replicative	replicative	JJ
cord-259603-bh198xgl	1010	9	endoribonuclease	endoribonuclease	NN
cord-259603-bh198xgl	1010	10	Multiple	multiple	JJ
cord-259603-bh198xgl	1010	11	enzymatic	enzymatic	JJ
cord-259603-bh198xgl	1010	12	activities	activity	NNS
cord-259603-bh198xgl	1010	13	associated	associate	VBN
cord-259603-bh198xgl	1010	14	with	with	IN
cord-259603-bh198xgl	1010	15	severe	severe	JJ
cord-259603-bh198xgl	1010	16	acute	acute	JJ
cord-259603-bh198xgl	1010	17	respiratory	respiratory	JJ
cord-259603-bh198xgl	1010	18	syndrome	syndrome	NN
cord-259603-bh198xgl	1010	19	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1010	20	helicase	helicase	NN
cord-259603-bh198xgl	1010	21	Characterization	characterization	NN
cord-259603-bh198xgl	1010	22	of	of	IN
cord-259603-bh198xgl	1010	23	the	the	DT
cord-259603-bh198xgl	1010	24	guanine	guanine	NN
cord-259603-bh198xgl	1010	25	-	-	HYPH
cord-259603-bh198xgl	1010	26	N7	n7	NN
cord-259603-bh198xgl	1010	27	methyltransferase	methyltransferase	NN
cord-259603-bh198xgl	1010	28	activity	activity	NN
cord-259603-bh198xgl	1010	29	of	of	IN
cord-259603-bh198xgl	1010	30	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1010	31	nsp14	nsp14	XX
cord-259603-bh198xgl	1010	32	on	on	IN
cord-259603-bh198xgl	1010	33	nucleotide	nucleotide	JJ
cord-259603-bh198xgl	1010	34	GTP	GTP	NNP
cord-259603-bh198xgl	1010	35	NMR	NMR	NNP
cord-259603-bh198xgl	1010	36	structure	structure	NN
cord-259603-bh198xgl	1010	37	of	of	IN
cord-259603-bh198xgl	1010	38	the	the	DT
cord-259603-bh198xgl	1010	39	SARS	SARS	NNP
cord-259603-bh198xgl	1010	40	-	-	HYPH
cord-259603-bh198xgl	1010	41	CoV	CoV	NNP
cord-259603-bh198xgl	1010	42	nonstructural	nonstructural	NNP
cord-259603-bh198xgl	1010	43	protein	protein	NNP
cord-259603-bh198xgl	1010	44	7	7	CD
cord-259603-bh198xgl	1010	45	in	in	IN
cord-259603-bh198xgl	1010	46	solution	solution	NN
cord-259603-bh198xgl	1010	47	at	at	IN
cord-259603-bh198xgl	1010	48	pH	pH	NNP
cord-259603-bh198xgl	1010	49	6.5	6.5	CD
cord-259603-bh198xgl	1010	50	Crystal	Crystal	NNP
cord-259603-bh198xgl	1010	51	structure	structure	NN
cord-259603-bh198xgl	1010	52	of	of	IN
cord-259603-bh198xgl	1010	53	a	a	DT
cord-259603-bh198xgl	1010	54	monomeric	monomeric	JJ
cord-259603-bh198xgl	1010	55	form	form	NN
cord-259603-bh198xgl	1010	56	of	of	IN
cord-259603-bh198xgl	1010	57	severe	severe	JJ
cord-259603-bh198xgl	1010	58	acute	acute	JJ
cord-259603-bh198xgl	1010	59	respiratory	respiratory	JJ
cord-259603-bh198xgl	1010	60	syndrome	syndrome	NN
cord-259603-bh198xgl	1010	61	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1010	62	endonuclease	endonuclease	NN
cord-259603-bh198xgl	1011	1	nsp15	nsp15	PRP
cord-259603-bh198xgl	1011	2	suggests	suggest	VBZ
cord-259603-bh198xgl	1011	3	a	a	DT
cord-259603-bh198xgl	1011	4	role	role	NN
cord-259603-bh198xgl	1011	5	for	for	IN
cord-259603-bh198xgl	1011	6	hexamerization	hexamerization	NN
cord-259603-bh198xgl	1011	7	as	as	IN
cord-259603-bh198xgl	1011	8	an	an	DT
cord-259603-bh198xgl	1011	9	allosteric	allosteric	JJ
cord-259603-bh198xgl	1011	10	switch	switch	NN
cord-259603-bh198xgl	1011	11	Virus	virus	NN
cord-259603-bh198xgl	1011	12	-	-	HYPH
cord-259603-bh198xgl	1011	13	encoded	encode	VBN
cord-259603-bh198xgl	1011	14	RNA	RNA	NNP
cord-259603-bh198xgl	1011	15	helicases	helicase	NNS
cord-259603-bh198xgl	1011	16	Biochemical	biochemical	JJ
cord-259603-bh198xgl	1011	17	and	and	CC
cord-259603-bh198xgl	1011	18	genetic	genetic	JJ
cord-259603-bh198xgl	1011	19	analyses	analysis	NNS
cord-259603-bh198xgl	1011	20	of	of	IN
cord-259603-bh198xgl	1011	21	murine	murine	JJ
cord-259603-bh198xgl	1011	22	hepatitis	hepatitis	NN
cord-259603-bh198xgl	1011	23	virus	virus	NN
cord-259603-bh198xgl	1012	1	Nsp15	Nsp15	NNP
cord-259603-bh198xgl	1012	2	endoribonuclease	endoribonuclease	NN
cord-259603-bh198xgl	1012	3	Short	short	JJ
cord-259603-bh198xgl	1012	4	peptides	peptide	NNS
cord-259603-bh198xgl	1012	5	derived	derive	VBN
cord-259603-bh198xgl	1012	6	from	from	IN
cord-259603-bh198xgl	1012	7	the	the	DT
cord-259603-bh198xgl	1012	8	interaction	interaction	NN
cord-259603-bh198xgl	1012	9	domain	domain	NN
cord-259603-bh198xgl	1012	10	of	of	IN
cord-259603-bh198xgl	1012	11	SARS	SARS	NNP
cord-259603-bh198xgl	1012	12	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1012	13	nonstructural	nonstructural	JJ
cord-259603-bh198xgl	1012	14	protein	protein	NN
cord-259603-bh198xgl	1012	15	nsp10	nsp10	RB
cord-259603-bh198xgl	1012	16	can	can	MD
cord-259603-bh198xgl	1012	17	suppress	suppress	VB
cord-259603-bh198xgl	1012	18	the	the	DT
cord-259603-bh198xgl	1012	19	2	2	CD
cord-259603-bh198xgl	1012	20	0	0	CD
cord-259603-bh198xgl	1012	21	-O	-O	:
cord-259603-bh198xgl	1012	22	-	-	HYPH
cord-259603-bh198xgl	1012	23	methyltransferase	methyltransferase	JJ
cord-259603-bh198xgl	1012	24	activity	activity	NN
cord-259603-bh198xgl	1012	25	of	of	IN
cord-259603-bh198xgl	1012	26	nsp10	nsp10	NNPS
cord-259603-bh198xgl	1012	27	/	/	SYM
cord-259603-bh198xgl	1012	28	nsp16	nsp16	NNS
cord-259603-bh198xgl	1012	29	complex	complex	JJ
cord-259603-bh198xgl	1012	30	Synthesis	Synthesis	NNP
cord-259603-bh198xgl	1012	31	of	of	IN
cord-259603-bh198xgl	1012	32	novel	novel	JJ
cord-259603-bh198xgl	1012	33	test	test	NN
cord-259603-bh198xgl	1012	34	compounds	compound	NNS
cord-259603-bh198xgl	1012	35	for	for	IN
cord-259603-bh198xgl	1012	36	antiviral	antiviral	JJ
cord-259603-bh198xgl	1012	37	chemotherapy	chemotherapy	NN
cord-259603-bh198xgl	1012	38	of	of	IN
cord-259603-bh198xgl	1012	39	severe	severe	JJ
cord-259603-bh198xgl	1012	40	acute	acute	JJ
cord-259603-bh198xgl	1012	41	respiratory	respiratory	JJ
cord-259603-bh198xgl	1012	42	syndrome	syndrome	NN
cord-259603-bh198xgl	1012	43	(	(	-LRB-
cord-259603-bh198xgl	1012	44	SARS	SARS	NNP
cord-259603-bh198xgl	1012	45	)	)	-RRB-
cord-259603-bh198xgl	1012	46	2,6-Bisarylmethyloxy-5-hydroxychromones	2,6-bisarylmethyloxy-5-hydroxychromones	CD
cord-259603-bh198xgl	1012	47	with	with	IN
cord-259603-bh198xgl	1012	48	antiviral	antiviral	JJ
cord-259603-bh198xgl	1012	49	activity	activity	NN
cord-259603-bh198xgl	1012	50	against	against	IN
cord-259603-bh198xgl	1012	51	both	both	DT
cord-259603-bh198xgl	1012	52	hepatitis	hepatitis	NN
cord-259603-bh198xgl	1012	53	C	c	NN
cord-259603-bh198xgl	1012	54	virus	virus	NN
cord-259603-bh198xgl	1012	55	(	(	-LRB-
cord-259603-bh198xgl	1012	56	HCV	HCV	NNP
cord-259603-bh198xgl	1012	57	)	)	-RRB-
cord-259603-bh198xgl	1012	58	and	and	CC
cord-259603-bh198xgl	1012	59	SARS	SARS	NNP
cord-259603-bh198xgl	1012	60	-	-	HYPH
cord-259603-bh198xgl	1012	61	associated	associate	VBN
cord-259603-bh198xgl	1012	62	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1013	1	(	(	-LRB-
cord-259603-bh198xgl	1013	2	SCV	SCV	NNP
cord-259603-bh198xgl	1013	3	)	)	-RRB-
cord-259603-bh198xgl	1013	4	SARS	SARS	NNP
cord-259603-bh198xgl	1013	5	-	-	HYPH
cord-259603-bh198xgl	1013	6	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1013	7	replication	replication	NN
cord-259603-bh198xgl	1013	8	is	be	VBZ
cord-259603-bh198xgl	1013	9	supported	support	VBN
cord-259603-bh198xgl	1013	10	by	by	IN
cord-259603-bh198xgl	1013	11	a	a	DT
cord-259603-bh198xgl	1013	12	reticulovesicular	reticulovesicular	JJ
cord-259603-bh198xgl	1013	13	network	network	NN
cord-259603-bh198xgl	1013	14	of	of	IN
cord-259603-bh198xgl	1013	15	modified	modify	VBN
cord-259603-bh198xgl	1013	16	endoplasmic	endoplasmic	NN
cord-259603-bh198xgl	1013	17	reticulum	reticulum	NN
cord-259603-bh198xgl	1013	18	Viral	Viral	NNP
cord-259603-bh198xgl	1013	19	and	and	CC
cord-259603-bh198xgl	1013	20	cellular	cellular	JJ
cord-259603-bh198xgl	1013	21	RNA	RNA	NNP
cord-259603-bh198xgl	1013	22	helicases	helicase	NNS
cord-259603-bh198xgl	1013	23	as	as	IN
cord-259603-bh198xgl	1013	24	antiviral	antiviral	JJ
cord-259603-bh198xgl	1013	25	targets	target	NNS
cord-259603-bh198xgl	1013	26	The	the	DT
cord-259603-bh198xgl	1013	27	molecular	molecular	JJ
cord-259603-bh198xgl	1013	28	biology	biology	NN
cord-259603-bh198xgl	1013	29	of	of	IN
cord-259603-bh198xgl	1013	30	coronaviruses	coronaviruse	NNS
cord-259603-bh198xgl	1013	31	Comparative	Comparative	NNP
cord-259603-bh198xgl	1013	32	analysis	analysis	NN
cord-259603-bh198xgl	1013	33	of	of	IN
cord-259603-bh198xgl	1013	34	RNA	RNA	NNP
cord-259603-bh198xgl	1013	35	genomes	genome	NNS
cord-259603-bh198xgl	1013	36	of	of	IN
cord-259603-bh198xgl	1013	37	mouse	mouse	NN
cord-259603-bh198xgl	1013	38	hepatitis	hepatitis	NN
cord-259603-bh198xgl	1013	39	viruses	virus	NNS
cord-259603-bh198xgl	1013	40	Purification	purification	NN
cord-259603-bh198xgl	1013	41	,	,	,
cord-259603-bh198xgl	1013	42	cloning	cloning	NN
cord-259603-bh198xgl	1013	43	,	,	,
cord-259603-bh198xgl	1013	44	and	and	CC
cord-259603-bh198xgl	1013	45	characterization	characterization	NN
cord-259603-bh198xgl	1013	46	of	of	IN
cord-259603-bh198xgl	1013	47	XendoU	xendou	NN
cord-259603-bh198xgl	1013	48	,	,	,
cord-259603-bh198xgl	1013	49	a	a	DT
cord-259603-bh198xgl	1013	50	novel	novel	JJ
cord-259603-bh198xgl	1013	51	endoribonuclease	endoribonuclease	NN
cord-259603-bh198xgl	1013	52	involved	involve	VBN
cord-259603-bh198xgl	1013	53	in	in	IN
cord-259603-bh198xgl	1013	54	processing	processing	NN
cord-259603-bh198xgl	1013	55	of	of	IN
cord-259603-bh198xgl	1013	56	intron	intron	NN
cord-259603-bh198xgl	1013	57	-	-	HYPH
cord-259603-bh198xgl	1013	58	encoded	encode	VBN
cord-259603-bh198xgl	1013	59	small	small	JJ
cord-259603-bh198xgl	1013	60	nucleolar	nucleolar	JJ
cord-259603-bh198xgl	1013	61	RNAs	rna	NNS
cord-259603-bh198xgl	1013	62	in	in	IN
cord-259603-bh198xgl	1013	63	Xenopus	Xenopus	NNP
cord-259603-bh198xgl	1013	64	laevis	laevi	NNS
cord-259603-bh198xgl	1014	1	The	the	DT
cord-259603-bh198xgl	1014	2	tumor	tumor	NN
cord-259603-bh198xgl	1014	3	marker	marker	NN
cord-259603-bh198xgl	1014	4	human	human	JJ
cord-259603-bh198xgl	1014	5	placental	placental	NN
cord-259603-bh198xgl	1014	6	protein	protein	NN
cord-259603-bh198xgl	1014	7	11	11	CD
cord-259603-bh198xgl	1014	8	is	be	VBZ
cord-259603-bh198xgl	1014	9	an	an	DT
cord-259603-bh198xgl	1014	10	endoribonuclease	endoribonuclease	NN
cord-259603-bh198xgl	1015	1	Mesoniviridae	Mesoniviridae	NNP
cord-259603-bh198xgl	1015	2	:	:	:
cord-259603-bh198xgl	1015	3	a	a	DT
cord-259603-bh198xgl	1015	4	proposed	propose	VBN
cord-259603-bh198xgl	1015	5	new	new	JJ
cord-259603-bh198xgl	1015	6	family	family	NN
cord-259603-bh198xgl	1015	7	in	in	IN
cord-259603-bh198xgl	1015	8	the	the	DT
cord-259603-bh198xgl	1015	9	order	order	NN
cord-259603-bh198xgl	1015	10	Nidovirales	Nidovirales	NNP
cord-259603-bh198xgl	1015	11	formed	form	VBN
cord-259603-bh198xgl	1015	12	by	by	IN
cord-259603-bh198xgl	1015	13	a	a	DT
cord-259603-bh198xgl	1015	14	single	single	JJ
cord-259603-bh198xgl	1015	15	species	species	NN
cord-259603-bh198xgl	1015	16	of	of	IN
cord-259603-bh198xgl	1015	17	mosquito	mosquito	NN
cord-259603-bh198xgl	1015	18	-	-	HYPH
cord-259603-bh198xgl	1015	19	borne	bear	VBN
cord-259603-bh198xgl	1015	20	viruses	virus	NNS
cord-259603-bh198xgl	1016	1	The	the	DT
cord-259603-bh198xgl	1016	2	footprint	footprint	NN
cord-259603-bh198xgl	1016	3	of	of	IN
cord-259603-bh198xgl	1016	4	genome	genome	NN
cord-259603-bh198xgl	1016	5	architecture	architecture	NN
cord-259603-bh198xgl	1016	6	in	in	IN
cord-259603-bh198xgl	1016	7	the	the	DT
cord-259603-bh198xgl	1016	8	largest	large	JJS
cord-259603-bh198xgl	1016	9	genome	genome	NN
cord-259603-bh198xgl	1016	10	expansion	expansion	NN
cord-259603-bh198xgl	1016	11	in	in	IN
cord-259603-bh198xgl	1016	12	RNA	RNA	NNP
cord-259603-bh198xgl	1016	13	viruses	virus	NNS
cord-259603-bh198xgl	1016	14	Discovery	Discovery	NNP
cord-259603-bh198xgl	1016	15	of	of	IN
cord-259603-bh198xgl	1016	16	an	an	DT
cord-259603-bh198xgl	1016	17	essential	essential	JJ
cord-259603-bh198xgl	1016	18	nucleotidylating	nucleotidylate	VBG
cord-259603-bh198xgl	1016	19	activity	activity	NN
cord-259603-bh198xgl	1016	20	associated	associate	VBN
cord-259603-bh198xgl	1016	21	with	with	IN
cord-259603-bh198xgl	1016	22	a	a	DT
cord-259603-bh198xgl	1016	23	newly	newly	RB
cord-259603-bh198xgl	1016	24	delineated	delineate	VBN
cord-259603-bh198xgl	1016	25	conserved	conserved	JJ
cord-259603-bh198xgl	1016	26	domain	domain	NN
cord-259603-bh198xgl	1016	27	in	in	IN
cord-259603-bh198xgl	1016	28	the	the	DT
cord-259603-bh198xgl	1016	29	RNA	RNA	NNP
cord-259603-bh198xgl	1016	30	polymerase	polymerase	NN
cord-259603-bh198xgl	1016	31	-	-	HYPH
cord-259603-bh198xgl	1016	32	containing	contain	VBG
cord-259603-bh198xgl	1016	33	protein	protein	NN
cord-259603-bh198xgl	1016	34	of	of	IN
cord-259603-bh198xgl	1016	35	all	all	DT
cord-259603-bh198xgl	1016	36	nidoviruses	nidoviruses	NNPS
cord-259603-bh198xgl	1016	37	Arterivirus	Arterivirus	NNP
cord-259603-bh198xgl	1016	38	nsp12	nsp12	CD
cord-259603-bh198xgl	1016	39	versus	versus	IN
cord-259603-bh198xgl	1016	40	the	the	DT
cord-259603-bh198xgl	1016	41	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1016	42	nsp16	nsp16	NNS
cord-259603-bh198xgl	1017	1	2	2	LS
cord-259603-bh198xgl	1017	2	0	0	CD
cord-259603-bh198xgl	1017	3	-O	-o	CD
cord-259603-bh198xgl	1017	4	-	-	HYPH
cord-259603-bh198xgl	1017	5	methyltransferase	methyltransferase	NN
cord-259603-bh198xgl	1017	6	:	:	:
cord-259603-bh198xgl	1017	7	comparison	comparison	NN
cord-259603-bh198xgl	1017	8	of	of	IN
cord-259603-bh198xgl	1017	9	the	the	DT
cord-259603-bh198xgl	1017	10	C	C	NNP
cord-259603-bh198xgl	1017	11	-	-	HYPH
cord-259603-bh198xgl	1017	12	terminal	terminal	NN
cord-259603-bh198xgl	1017	13	cleavage	cleavage	NN
cord-259603-bh198xgl	1017	14	products	product	NNS
cord-259603-bh198xgl	1017	15	of	of	IN
cord-259603-bh198xgl	1017	16	two	two	CD
cord-259603-bh198xgl	1017	17	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	1017	18	pp1ab	pp1ab	NNP
cord-259603-bh198xgl	1017	19	polyproteins	polyprotein	NNS
cord-259603-bh198xgl	1018	1	What	what	WP
cord-259603-bh198xgl	1018	2	we	-PRON-	PRP
cord-259603-bh198xgl	1018	3	know	know	VBP
cord-259603-bh198xgl	1018	4	but	but	CC
cord-259603-bh198xgl	1018	5	do	do	VBP
cord-259603-bh198xgl	1018	6	not	not	RB
cord-259603-bh198xgl	1018	7	understand	understand	VB
cord-259603-bh198xgl	1018	8	about	about	IN
cord-259603-bh198xgl	1018	9	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	1018	10	helicases	helicase	NNS
cord-259603-bh198xgl	1018	11	MAVS	mavs	RB
cord-259603-bh198xgl	1018	12	-	-	HYPH
cord-259603-bh198xgl	1018	13	mediated	mediate	VBN
cord-259603-bh198xgl	1018	14	apoptosis	apoptosis	NN
cord-259603-bh198xgl	1018	15	and	and	CC
cord-259603-bh198xgl	1018	16	its	-PRON-	PRP$
cord-259603-bh198xgl	1018	17	inhibition	inhibition	NN
cord-259603-bh198xgl	1018	18	by	by	IN
cord-259603-bh198xgl	1018	19	viral	viral	JJ
cord-259603-bh198xgl	1018	20	proteins	protein	NNS
cord-259603-bh198xgl	1018	21	Decapping	decappe	VBG
cord-259603-bh198xgl	1018	22	the	the	DT
cord-259603-bh198xgl	1018	23	message	message	NN
cord-259603-bh198xgl	1018	24	:	:	:
cord-259603-bh198xgl	1018	25	a	a	DT
cord-259603-bh198xgl	1018	26	beginning	beginning	NN
cord-259603-bh198xgl	1018	27	or	or	CC
cord-259603-bh198xgl	1018	28	an	an	DT
cord-259603-bh198xgl	1018	29	end	end	NN
cord-259603-bh198xgl	1018	30	Complementation	Complementation	NNP
cord-259603-bh198xgl	1018	31	analysis	analysis	NN
cord-259603-bh198xgl	1018	32	of	of	IN
cord-259603-bh198xgl	1018	33	the	the	DT
cord-259603-bh198xgl	1018	34	flavivirus	flavivirus	NNP
cord-259603-bh198xgl	1018	35	Kunjin	Kunjin	NNP
cord-259603-bh198xgl	1018	36	NS3	NS3	NNP
cord-259603-bh198xgl	1018	37	and	and	CC
cord-259603-bh198xgl	1018	38	NS5	ns5	JJ
cord-259603-bh198xgl	1018	39	proteins	protein	NNS
cord-259603-bh198xgl	1018	40	defines	define	VBZ
cord-259603-bh198xgl	1018	41	the	the	DT
cord-259603-bh198xgl	1018	42	minimal	minimal	JJ
cord-259603-bh198xgl	1018	43	regions	region	NNS
cord-259603-bh198xgl	1018	44	essential	essential	JJ
cord-259603-bh198xgl	1018	45	for	for	IN
cord-259603-bh198xgl	1018	46	formation	formation	NN
cord-259603-bh198xgl	1018	47	of	of	IN
cord-259603-bh198xgl	1018	48	a	a	DT
cord-259603-bh198xgl	1018	49	replication	replication	NN
cord-259603-bh198xgl	1018	50	complex	complex	NN
cord-259603-bh198xgl	1018	51	and	and	CC
cord-259603-bh198xgl	1018	52	shows	show	VBZ
cord-259603-bh198xgl	1018	53	a	a	DT
cord-259603-bh198xgl	1018	54	requirement	requirement	NN
cord-259603-bh198xgl	1018	55	of	of	IN
cord-259603-bh198xgl	1018	56	NS3	ns3	RB
cord-259603-bh198xgl	1018	57	in	in	IN
cord-259603-bh198xgl	1018	58	cis	cis	NNP
cord-259603-bh198xgl	1018	59	for	for	IN
cord-259603-bh198xgl	1018	60	virus	virus	NNP
cord-259603-bh198xgl	1018	61	assembly	assembly	NNP
cord-259603-bh198xgl	1018	62	Accessory	Accessory	NNP
cord-259603-bh198xgl	1018	63	proteins	protein	NNS
cord-259603-bh198xgl	1018	64	of	of	IN
cord-259603-bh198xgl	1018	65	SARS	SARS	NNP
cord-259603-bh198xgl	1018	66	-	-	HYPH
cord-259603-bh198xgl	1018	67	CoV	CoV	NNP
cord-259603-bh198xgl	1018	68	and	and	CC
cord-259603-bh198xgl	1018	69	other	other	JJ
cord-259603-bh198xgl	1018	70	coronaviruses	coronaviruse	NNS
cord-259603-bh198xgl	1019	1	Molecular	molecular	JJ
cord-259603-bh198xgl	1019	2	mapping	mapping	NN
cord-259603-bh198xgl	1019	3	of	of	IN
cord-259603-bh198xgl	1019	4	the	the	DT
cord-259603-bh198xgl	1019	5	RNA	RNA	NNP
cord-259603-bh198xgl	1019	6	Cap	Cap	NNP
cord-259603-bh198xgl	1020	1	2	2	LS
cord-259603-bh198xgl	1020	2	0	0	CD
cord-259603-bh198xgl	1020	3	-O	-O	:
cord-259603-bh198xgl	1020	4	-	-	HYPH
cord-259603-bh198xgl	1020	5	methyltransferase	methyltransferase	NN
cord-259603-bh198xgl	1020	6	activation	activation	NN
cord-259603-bh198xgl	1020	7	interface	interface	NN
cord-259603-bh198xgl	1020	8	between	between	IN
cord-259603-bh198xgl	1020	9	severe	severe	JJ
cord-259603-bh198xgl	1020	10	acute	acute	JJ
cord-259603-bh198xgl	1020	11	respiratory	respiratory	JJ
cord-259603-bh198xgl	1020	12	syndrome	syndrome	NN
cord-259603-bh198xgl	1020	13	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1020	14	nsp10	nsp10	RB
cord-259603-bh198xgl	1020	15	and	and	CC
cord-259603-bh198xgl	1020	16	nsp16	nsp16	NNS
cord-259603-bh198xgl	1020	17	NS3	ns3	RB
cord-259603-bh198xgl	1020	18	helicase	helicase	NN
cord-259603-bh198xgl	1020	19	domains	domain	NNS
cord-259603-bh198xgl	1020	20	involved	involve	VBN
cord-259603-bh198xgl	1020	21	in	in	IN
cord-259603-bh198xgl	1020	22	infectious	infectious	JJ
cord-259603-bh198xgl	1020	23	intracellular	intracellular	JJ
cord-259603-bh198xgl	1020	24	hepatitis	hepatitis	NN
cord-259603-bh198xgl	1020	25	C	c	NN
cord-259603-bh198xgl	1020	26	virus	virus	NN
cord-259603-bh198xgl	1020	27	particle	particle	NN
cord-259603-bh198xgl	1020	28	assembly	assembly	NN
cord-259603-bh198xgl	1020	29	Structural	structural	JJ
cord-259603-bh198xgl	1020	30	basis	basis	NN
cord-259603-bh198xgl	1020	31	and	and	CC
cord-259603-bh198xgl	1020	32	functional	functional	JJ
cord-259603-bh198xgl	1020	33	analysis	analysis	NN
cord-259603-bh198xgl	1020	34	of	of	IN
cord-259603-bh198xgl	1020	35	the	the	DT
cord-259603-bh198xgl	1020	36	SARS	SARS	NNP
cord-259603-bh198xgl	1020	37	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1020	38	nsp14-nsp10	nsp14-nsp10	JJ
cord-259603-bh198xgl	1020	39	complex	complex	JJ
cord-259603-bh198xgl	1020	40	RNA	RNA	NNP
cord-259603-bh198xgl	1020	41	structure	structure	NN
cord-259603-bh198xgl	1020	42	analysis	analysis	NN
cord-259603-bh198xgl	1020	43	of	of	IN
cord-259603-bh198xgl	1020	44	alphacoronavirus	alphacoronavirus	NNP
cord-259603-bh198xgl	1020	45	terminal	terminal	NNP
cord-259603-bh198xgl	1020	46	genome	genome	NN
cord-259603-bh198xgl	1020	47	regions	region	NNS
cord-259603-bh198xgl	1020	48	Infectious	infectious	JJ
cord-259603-bh198xgl	1020	49	bronchitis	bronchitis	NN
cord-259603-bh198xgl	1020	50	virus	virus	NN
cord-259603-bh198xgl	1020	51	generates	generate	VBZ
cord-259603-bh198xgl	1020	52	spherules	spherule	NNS
cord-259603-bh198xgl	1020	53	from	from	IN
cord-259603-bh198xgl	1020	54	zippered	zippered	JJ
cord-259603-bh198xgl	1020	55	endoplasmic	endoplasmic	NN
cord-259603-bh198xgl	1020	56	reticulum	reticulum	NN
cord-259603-bh198xgl	1020	57	membranes	membrane	VBZ
cord-259603-bh198xgl	1020	58	The	the	DT
cord-259603-bh198xgl	1020	59	non	non	JJ
cord-259603-bh198xgl	1020	60	-	-	JJ
cord-259603-bh198xgl	1020	61	structural	structural	JJ
cord-259603-bh198xgl	1020	62	protein	protein	NN
cord-259603-bh198xgl	1020	63	Nsp10	Nsp10	NNP
cord-259603-bh198xgl	1020	64	of	of	IN
cord-259603-bh198xgl	1020	65	mouse	mouse	NNP
cord-259603-bh198xgl	1020	66	hepatitis	hepatitis	NNP
cord-259603-bh198xgl	1020	67	virus	virus	NN
cord-259603-bh198xgl	1020	68	binds	bind	VBZ
cord-259603-bh198xgl	1020	69	zinc	zinc	NN
cord-259603-bh198xgl	1020	70	ions	ion	NNS
cord-259603-bh198xgl	1020	71	and	and	CC
cord-259603-bh198xgl	1020	72	nucleic	nucleic	JJ
cord-259603-bh198xgl	1020	73	acids	acid	NNS
cord-259603-bh198xgl	1020	74	Bugs	bug	NNS
cord-259603-bh198xgl	1020	75	in	in	IN
cord-259603-bh198xgl	1020	76	the	the	DT
cord-259603-bh198xgl	1020	77	system	system	NN
cord-259603-bh198xgl	1020	78	Attenuation	attenuation	NN
cord-259603-bh198xgl	1020	79	and	and	CC
cord-259603-bh198xgl	1020	80	restoration	restoration	NN
cord-259603-bh198xgl	1020	81	of	of	IN
cord-259603-bh198xgl	1020	82	severe	severe	JJ
cord-259603-bh198xgl	1020	83	acute	acute	JJ
cord-259603-bh198xgl	1020	84	respiratory	respiratory	JJ
cord-259603-bh198xgl	1020	85	syndrome	syndrome	NN
cord-259603-bh198xgl	1020	86	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1020	87	mutant	mutant	NN
cord-259603-bh198xgl	1020	88	lacking	lack	VBG
cord-259603-bh198xgl	1020	89	2	2	CD
cord-259603-bh198xgl	1020	90	0	0	CD
cord-259603-bh198xgl	1020	91	-O	-O	:
cord-259603-bh198xgl	1020	92	-	-	HYPH
cord-259603-bh198xgl	1020	93	methyltransferase	methyltransferase	NN
cord-259603-bh198xgl	1020	94	activity	activity	NN
cord-259603-bh198xgl	1021	1	A	a	DT
cord-259603-bh198xgl	1021	2	SARS	SARS	NNP
cord-259603-bh198xgl	1021	3	-	-	HYPH
cord-259603-bh198xgl	1021	4	like	like	JJ
cord-259603-bh198xgl	1021	5	cluster	cluster	NN
cord-259603-bh198xgl	1021	6	of	of	IN
cord-259603-bh198xgl	1021	7	circulating	circulate	VBG
cord-259603-bh198xgl	1021	8	bat	bat	NN
cord-259603-bh198xgl	1021	9	coronaviruses	coronaviruse	NNS
cord-259603-bh198xgl	1021	10	shows	show	VBZ
cord-259603-bh198xgl	1021	11	potential	potential	NN
cord-259603-bh198xgl	1021	12	for	for	IN
cord-259603-bh198xgl	1021	13	human	human	JJ
cord-259603-bh198xgl	1021	14	emergence	emergence	NN
cord-259603-bh198xgl	1022	1	Nidovirus	Nidovirus	NNP
cord-259603-bh198xgl	1022	2	papain	papain	NN
cord-259603-bh198xgl	1022	3	-	-	HYPH
cord-259603-bh198xgl	1022	4	like	like	JJ
cord-259603-bh198xgl	1022	5	proteases	protease	NNS
cord-259603-bh198xgl	1022	6	:	:	:
cord-259603-bh198xgl	1022	7	multifunctional	multifunctional	JJ
cord-259603-bh198xgl	1022	8	enzymes	enzyme	NNS
cord-259603-bh198xgl	1022	9	with	with	IN
cord-259603-bh198xgl	1022	10	protease	protease	NN
cord-259603-bh198xgl	1022	11	,	,	,
cord-259603-bh198xgl	1022	12	deubiquitinating	deubiquitinating	NN
cord-259603-bh198xgl	1022	13	and	and	CC
cord-259603-bh198xgl	1022	14	deISGylating	deisgylate	VBG
cord-259603-bh198xgl	1022	15	activities	activity	NNS
cord-259603-bh198xgl	1023	1	Severe	severe	JJ
cord-259603-bh198xgl	1023	2	acute	acute	JJ
cord-259603-bh198xgl	1023	3	respiratory	respiratory	JJ
cord-259603-bh198xgl	1023	4	syndrome	syndrome	NN
cord-259603-bh198xgl	1023	5	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1024	1	nsp9	nsp9	DT
cord-259603-bh198xgl	1024	2	dimerization	dimerization	NN
cord-259603-bh198xgl	1024	3	is	be	VBZ
cord-259603-bh198xgl	1024	4	essential	essential	JJ
cord-259603-bh198xgl	1024	5	for	for	IN
cord-259603-bh198xgl	1024	6	efficient	efficient	JJ
cord-259603-bh198xgl	1024	7	viral	viral	JJ
cord-259603-bh198xgl	1024	8	growth	growth	NN
cord-259603-bh198xgl	1024	9	Discovery	Discovery	NNP
cord-259603-bh198xgl	1024	10	of	of	IN
cord-259603-bh198xgl	1024	11	an	an	DT
cord-259603-bh198xgl	1024	12	RNA	RNA	NNP
cord-259603-bh198xgl	1024	13	virus	virus	NN
cord-259603-bh198xgl	1024	14	3	3	CD
cord-259603-bh198xgl	1024	15	0	0	CD
cord-259603-bh198xgl	1024	16	!	!	.
cord-259603-bh198xgl	1025	1	5	5	LS
cord-259603-bh198xgl	1025	2	0	0	CD
cord-259603-bh198xgl	1025	3	exoribonuclease	exoribonuclease	NN
cord-259603-bh198xgl	1025	4	that	that	WDT
cord-259603-bh198xgl	1025	5	is	be	VBZ
cord-259603-bh198xgl	1025	6	critically	critically	RB
cord-259603-bh198xgl	1025	7	involved	involve	VBN
cord-259603-bh198xgl	1025	8	in	in	IN
cord-259603-bh198xgl	1025	9	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1025	10	RNA	RNA	NNP
cord-259603-bh198xgl	1025	11	synthesis	synthesis	NN
cord-259603-bh198xgl	1025	12	Identification	identification	NN
cord-259603-bh198xgl	1025	13	of	of	IN
cord-259603-bh198xgl	1025	14	cytoplasmic	cytoplasmic	JJ
cord-259603-bh198xgl	1025	15	capping	cap	VBG
cord-259603-bh198xgl	1025	16	targets	target	NNS
cord-259603-bh198xgl	1025	17	reveals	reveal	VBZ
cord-259603-bh198xgl	1025	18	a	a	DT
cord-259603-bh198xgl	1025	19	role	role	NN
cord-259603-bh198xgl	1025	20	for	for	IN
cord-259603-bh198xgl	1025	21	cap	cap	NN
cord-259603-bh198xgl	1025	22	homeostasis	homeostasis	NN
cord-259603-bh198xgl	1025	23	in	in	IN
cord-259603-bh198xgl	1025	24	translation	translation	NN
cord-259603-bh198xgl	1025	25	and	and	CC
cord-259603-bh198xgl	1026	1	mRNA	mRNA	NNP
cord-259603-bh198xgl	1026	2	stability	stability	NN
cord-259603-bh198xgl	1026	3	SARS	SARS	NNP
cord-259603-bh198xgl	1026	4	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1026	5	accessory	accessory	NN
cord-259603-bh198xgl	1026	6	proteins	protein	NNS
cord-259603-bh198xgl	1026	7	Biochemical	biochemical	JJ
cord-259603-bh198xgl	1026	8	characterization	characterization	NN
cord-259603-bh198xgl	1026	9	of	of	IN
cord-259603-bh198xgl	1026	10	arterivirus	arterivirus	NNP
cord-259603-bh198xgl	1026	11	nonstructural	nonstructural	NNP
cord-259603-bh198xgl	1026	12	protein	protein	NNP
cord-259603-bh198xgl	1026	13	11	11	CD
cord-259603-bh198xgl	1026	14	reveals	reveal	VBZ
cord-259603-bh198xgl	1026	15	the	the	DT
cord-259603-bh198xgl	1026	16	nidovirus	nidovirus	NN
cord-259603-bh198xgl	1026	17	-	-	HYPH
cord-259603-bh198xgl	1026	18	wide	wide	JJ
cord-259603-bh198xgl	1026	19	conservation	conservation	NN
cord-259603-bh198xgl	1026	20	of	of	IN
cord-259603-bh198xgl	1026	21	a	a	DT
cord-259603-bh198xgl	1026	22	replicative	replicative	JJ
cord-259603-bh198xgl	1026	23	endoribonuclease	endoribonuclease	NN
cord-259603-bh198xgl	1026	24	Arterivirus	Arterivirus	NNP
cord-259603-bh198xgl	1026	25	Nsp1	Nsp1	NNP
cord-259603-bh198xgl	1026	26	modulates	modulate	VBZ
cord-259603-bh198xgl	1026	27	the	the	DT
cord-259603-bh198xgl	1026	28	accumulation	accumulation	NN
cord-259603-bh198xgl	1026	29	of	of	IN
cord-259603-bh198xgl	1026	30	minus	minus	JJ
cord-259603-bh198xgl	1026	31	-	-	HYPH
cord-259603-bh198xgl	1026	32	strand	strand	NN
cord-259603-bh198xgl	1026	33	templates	template	NNS
cord-259603-bh198xgl	1026	34	to	to	TO
cord-259603-bh198xgl	1026	35	control	control	VB
cord-259603-bh198xgl	1026	36	the	the	DT
cord-259603-bh198xgl	1026	37	relative	relative	JJ
cord-259603-bh198xgl	1026	38	abundance	abundance	NN
cord-259603-bh198xgl	1026	39	of	of	IN
cord-259603-bh198xgl	1026	40	viral	viral	JJ
cord-259603-bh198xgl	1026	41	mRNAs	mRNAs	NNPS
cord-259603-bh198xgl	1026	42	Does	do	VBZ
cord-259603-bh198xgl	1026	43	form	form	VB
cord-259603-bh198xgl	1026	44	meet	meet	VB
cord-259603-bh198xgl	1026	45	function	function	NN
cord-259603-bh198xgl	1026	46	in	in	IN
cord-259603-bh198xgl	1026	47	the	the	DT
cord-259603-bh198xgl	1026	48	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1026	49	replicative	replicative	JJ
cord-259603-bh198xgl	1026	50	organelle	organelle	NN
cord-259603-bh198xgl	1026	51	?	?	.
cord-259603-bh198xgl	1027	1	Atlas	Atlas	NNP
cord-259603-bh198xgl	1027	2	of	of	IN
cord-259603-bh198xgl	1027	3	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1027	4	replicase	replicase	NN
cord-259603-bh198xgl	1027	5	structure	structure	NN
cord-259603-bh198xgl	1027	6	Further	further	JJ
cord-259603-bh198xgl	1027	7	identification	identification	NN
cord-259603-bh198xgl	1027	8	and	and	CC
cord-259603-bh198xgl	1027	9	characterization	characterization	NN
cord-259603-bh198xgl	1027	10	of	of	IN
cord-259603-bh198xgl	1027	11	products	product	NNS
cord-259603-bh198xgl	1027	12	processed	process	VBN
cord-259603-bh198xgl	1027	13	from	from	IN
cord-259603-bh198xgl	1027	14	the	the	DT
cord-259603-bh198xgl	1027	15	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1027	16	avian	avian	JJ
cord-259603-bh198xgl	1027	17	infectious	infectious	JJ
cord-259603-bh198xgl	1027	18	bronchitis	bronchitis	NN
cord-259603-bh198xgl	1027	19	virus	virus	NN
cord-259603-bh198xgl	1027	20	(	(	-LRB-
cord-259603-bh198xgl	1027	21	IBV	IBV	NNP
cord-259603-bh198xgl	1027	22	)	)	-RRB-
cord-259603-bh198xgl	1028	1	1a	1a	NNP
cord-259603-bh198xgl	1028	2	polyprotein	polyprotein	NNP
cord-259603-bh198xgl	1028	3	by	by	IN
cord-259603-bh198xgl	1028	4	the	the	DT
cord-259603-bh198xgl	1028	5	3C	3c	NN
cord-259603-bh198xgl	1028	6	-	-	HYPH
cord-259603-bh198xgl	1028	7	like	like	JJ
cord-259603-bh198xgl	1028	8	proteinase	proteinase	NN
cord-259603-bh198xgl	1028	9	Structure	structure	NN
cord-259603-bh198xgl	1028	10	-	-	HYPH
cord-259603-bh198xgl	1028	11	function	function	NN
cord-259603-bh198xgl	1028	12	relationships	relationship	NNS
cord-259603-bh198xgl	1028	13	among	among	IN
cord-259603-bh198xgl	1028	14	RNAdependent	RNAdependent	NNP
cord-259603-bh198xgl	1028	15	RNA	RNA	NNP
cord-259603-bh198xgl	1028	16	polymerases	polymerase	NNS
cord-259603-bh198xgl	1028	17	Discovery	Discovery	NNP
cord-259603-bh198xgl	1028	18	of	of	IN
cord-259603-bh198xgl	1028	19	the	the	DT
cord-259603-bh198xgl	1028	20	first	first	JJ
cord-259603-bh198xgl	1028	21	insect	insect	NN
cord-259603-bh198xgl	1028	22	nidovirus	nidovirus	NN
cord-259603-bh198xgl	1028	23	,	,	,
cord-259603-bh198xgl	1028	24	a	a	DT
cord-259603-bh198xgl	1028	25	missing	miss	VBG
cord-259603-bh198xgl	1028	26	evolutionary	evolutionary	JJ
cord-259603-bh198xgl	1028	27	link	link	NN
cord-259603-bh198xgl	1028	28	in	in	IN
cord-259603-bh198xgl	1028	29	the	the	DT
cord-259603-bh198xgl	1028	30	emergence	emergence	NN
cord-259603-bh198xgl	1028	31	of	of	IN
cord-259603-bh198xgl	1028	32	the	the	DT
cord-259603-bh198xgl	1028	33	largest	large	JJS
cord-259603-bh198xgl	1028	34	RNA	RNA	NNP
cord-259603-bh198xgl	1028	35	virus	virus	NN
cord-259603-bh198xgl	1028	36	genomes	genome	NNS
cord-259603-bh198xgl	1028	37	The	the	DT
cord-259603-bh198xgl	1028	38	C	c	NN
cord-259603-bh198xgl	1028	39	-	-	HYPH
cord-259603-bh198xgl	1028	40	terminal	terminal	NN
cord-259603-bh198xgl	1028	41	domain	domain	NN
cord-259603-bh198xgl	1028	42	of	of	IN
cord-259603-bh198xgl	1028	43	eukaryotic	eukaryotic	JJ
cord-259603-bh198xgl	1028	44	protein	protein	NN
cord-259603-bh198xgl	1028	45	synthesis	synthesis	NN
cord-259603-bh198xgl	1028	46	initiation	initiation	NN
cord-259603-bh198xgl	1028	47	factor	factor	NN
cord-259603-bh198xgl	1028	48	(	(	-LRB-
cord-259603-bh198xgl	1028	49	eIF	eIF	NNP
cord-259603-bh198xgl	1028	50	)	)	-RRB-
cord-259603-bh198xgl	1029	1	4	4	LS
cord-259603-bh198xgl	1029	2	G	g	NN
cord-259603-bh198xgl	1029	3	is	be	VBZ
cord-259603-bh198xgl	1029	4	sufficient	sufficient	JJ
cord-259603-bh198xgl	1029	5	to	to	TO
cord-259603-bh198xgl	1029	6	support	support	VB
cord-259603-bh198xgl	1029	7	cap	cap	NN
cord-259603-bh198xgl	1029	8	-	-	HYPH
cord-259603-bh198xgl	1029	9	independent	independent	JJ
cord-259603-bh198xgl	1029	10	translation	translation	NN
cord-259603-bh198xgl	1029	11	in	in	IN
cord-259603-bh198xgl	1029	12	the	the	DT
cord-259603-bh198xgl	1029	13	absence	absence	NN
cord-259603-bh198xgl	1029	14	of	of	IN
cord-259603-bh198xgl	1029	15	eIF4E	eif4e	CD
cord-259603-bh198xgl	1029	16	Genome	genome	NN
cord-259603-bh198xgl	1029	17	-	-	HYPH
cord-259603-bh198xgl	1029	18	wide	wide	JJ
cord-259603-bh198xgl	1029	19	analysis	analysis	NN
cord-259603-bh198xgl	1029	20	of	of	IN
cord-259603-bh198xgl	1029	21	protein	protein	NN
cord-259603-bh198xgl	1029	22	-	-	HYPH
cord-259603-bh198xgl	1029	23	protein	protein	NN
cord-259603-bh198xgl	1029	24	interactions	interaction	NNS
cord-259603-bh198xgl	1029	25	and	and	CC
cord-259603-bh198xgl	1029	26	involvement	involvement	NN
cord-259603-bh198xgl	1029	27	of	of	IN
cord-259603-bh198xgl	1029	28	viral	viral	JJ
cord-259603-bh198xgl	1029	29	proteins	protein	NNS
cord-259603-bh198xgl	1029	30	in	in	IN
cord-259603-bh198xgl	1029	31	SARS	SARS	NNP
cord-259603-bh198xgl	1029	32	-	-	HYPH
cord-259603-bh198xgl	1029	33	CoV	CoV	NNP
cord-259603-bh198xgl	1029	34	replication	replication	NN
cord-259603-bh198xgl	1029	35	Nidovirus	Nidovirus	NNP
cord-259603-bh198xgl	1029	36	transcription	transcription	NN
cord-259603-bh198xgl	1029	37	:	:	:
cord-259603-bh198xgl	1029	38	how	how	WRB
cord-259603-bh198xgl	1029	39	to	to	TO
cord-259603-bh198xgl	1029	40	make	make	VB
cord-259603-bh198xgl	1029	41	sen	sen	NNP
cord-259603-bh198xgl	1029	42	-	-	HYPH
cord-259603-bh198xgl	1029	43	se	se	FW
cord-259603-bh198xgl	1029	44	…	…	NFP
cord-259603-bh198xgl	1029	45	?	?	.
cord-259603-bh198xgl	1030	1	Identification	identification	NN
cord-259603-bh198xgl	1030	2	of	of	IN
cord-259603-bh198xgl	1030	3	an	an	DT
cord-259603-bh198xgl	1030	4	RNA	RNA	NNP
cord-259603-bh198xgl	1030	5	hairpin	hairpin	NN
cord-259603-bh198xgl	1030	6	in	in	IN
cord-259603-bh198xgl	1030	7	poliovirus	poliovirus	NN
cord-259603-bh198xgl	1030	8	RNA	RNA	NNP
cord-259603-bh198xgl	1030	9	that	that	WDT
cord-259603-bh198xgl	1030	10	serves	serve	VBZ
cord-259603-bh198xgl	1030	11	as	as	IN
cord-259603-bh198xgl	1030	12	the	the	DT
cord-259603-bh198xgl	1030	13	primary	primary	JJ
cord-259603-bh198xgl	1030	14	template	template	NN
cord-259603-bh198xgl	1030	15	in	in	IN
cord-259603-bh198xgl	1030	16	the	the	DT
cord-259603-bh198xgl	1030	17	in	in	FW
cord-259603-bh198xgl	1030	18	vitro	vitro	FW
cord-259603-bh198xgl	1030	19	uridylylation	uridylylation	NN
cord-259603-bh198xgl	1030	20	of	of	IN
cord-259603-bh198xgl	1030	21	VPg	VPg	NNP
cord-259603-bh198xgl	1030	22	Design	Design	NNP
cord-259603-bh198xgl	1030	23	,	,	,
cord-259603-bh198xgl	1030	24	synthesis	synthesis	NN
cord-259603-bh198xgl	1030	25	and	and	CC
cord-259603-bh198xgl	1030	26	evaluation	evaluation	NN
cord-259603-bh198xgl	1030	27	of	of	IN
cord-259603-bh198xgl	1030	28	a	a	DT
cord-259603-bh198xgl	1030	29	series	series	NN
cord-259603-bh198xgl	1030	30	of	of	IN
cord-259603-bh198xgl	1030	31	acyclic	acyclic	NNP
cord-259603-bh198xgl	1030	32	fleximer	fleximer	NNP
cord-259603-bh198xgl	1030	33	nucleoside	nucleoside	NN
cord-259603-bh198xgl	1030	34	analogues	analogue	NNS
cord-259603-bh198xgl	1030	35	with	with	IN
cord-259603-bh198xgl	1030	36	anti	anti	JJ
cord-259603-bh198xgl	1030	37	-	-	JJ
cord-259603-bh198xgl	1030	38	coronavirus	coronavirus	JJ
cord-259603-bh198xgl	1030	39	activity	activity	NN
cord-259603-bh198xgl	1030	40	Structural	structural	JJ
cord-259603-bh198xgl	1030	41	genomics	genomic	NNS
cord-259603-bh198xgl	1030	42	of	of	IN
cord-259603-bh198xgl	1030	43	the	the	DT
cord-259603-bh198xgl	1030	44	severe	severe	JJ
cord-259603-bh198xgl	1030	45	acute	acute	JJ
cord-259603-bh198xgl	1030	46	respiratory	respiratory	JJ
cord-259603-bh198xgl	1030	47	syndrome	syndrome	NN
cord-259603-bh198xgl	1030	48	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1030	49	:	:	:
cord-259603-bh198xgl	1030	50	nuclear	nuclear	JJ
cord-259603-bh198xgl	1030	51	magnetic	magnetic	JJ
cord-259603-bh198xgl	1030	52	resonance	resonance	NN
cord-259603-bh198xgl	1030	53	structure	structure	NN
cord-259603-bh198xgl	1030	54	of	of	IN
cord-259603-bh198xgl	1030	55	the	the	DT
cord-259603-bh198xgl	1030	56	protein	protein	NN
cord-259603-bh198xgl	1030	57	nsP7	nsP7	.
cord-259603-bh198xgl	1031	1	UCSF	UCSF	NNP
cord-259603-bh198xgl	1031	2	Chimera	Chimera	NNP
cord-259603-bh198xgl	1031	3	-	-	:
cord-259603-bh198xgl	1031	4	a	a	DT
cord-259603-bh198xgl	1031	5	visualization	visualization	NN
cord-259603-bh198xgl	1031	6	system	system	NN
cord-259603-bh198xgl	1031	7	for	for	IN
cord-259603-bh198xgl	1031	8	exploratory	exploratory	JJ
cord-259603-bh198xgl	1031	9	research	research	NN
cord-259603-bh198xgl	1031	10	and	and	CC
cord-259603-bh198xgl	1031	11	analysis	analysis	NN
cord-259603-bh198xgl	1032	1	IFIT1	IFIT1	NNP
cord-259603-bh198xgl	1032	2	is	be	VBZ
cord-259603-bh198xgl	1032	3	an	an	DT
cord-259603-bh198xgl	1032	4	antiviral	antiviral	JJ
cord-259603-bh198xgl	1032	5	protein	protein	NN
cord-259603-bh198xgl	1032	6	that	that	WDT
cord-259603-bh198xgl	1032	7	recognizes	recognize	VBZ
cord-259603-bh198xgl	1032	8	5	5	CD
cord-259603-bh198xgl	1032	9	0	0	CD
cord-259603-bh198xgl	1032	10	-triphosphate	-triphosphate	.
cord-259603-bh198xgl	1033	1	RNA	RNA	NNP
cord-259603-bh198xgl	1033	2	Variable	variable	JJ
cord-259603-bh198xgl	1033	3	oligomerization	oligomerization	NN
cord-259603-bh198xgl	1033	4	modes	mode	NNS
cord-259603-bh198xgl	1033	5	in	in	IN
cord-259603-bh198xgl	1033	6	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1033	7	non	non	JJ
cord-259603-bh198xgl	1033	8	-	-	JJ
cord-259603-bh198xgl	1033	9	structural	structural	JJ
cord-259603-bh198xgl	1033	10	protein	protein	NN
cord-259603-bh198xgl	1033	11	9	9	CD
cord-259603-bh198xgl	1033	12	Site	site	NN
cord-259603-bh198xgl	1033	13	-	-	HYPH
cord-259603-bh198xgl	1033	14	directed	direct	VBN
cord-259603-bh198xgl	1033	15	mutagenesis	mutagenesis	NN
cord-259603-bh198xgl	1033	16	of	of	IN
cord-259603-bh198xgl	1033	17	the	the	DT
cord-259603-bh198xgl	1033	18	Nidovirus	Nidovirus	NNP
cord-259603-bh198xgl	1033	19	replicative	replicative	JJ
cord-259603-bh198xgl	1033	20	endoribonuclease	endoribonuclease	NN
cord-259603-bh198xgl	1033	21	NendoU	NendoU	NNP
cord-259603-bh198xgl	1033	22	exerts	exert	VBZ
cord-259603-bh198xgl	1033	23	pleiotropic	pleiotropic	JJ
cord-259603-bh198xgl	1033	24	effects	effect	NNS
cord-259603-bh198xgl	1033	25	on	on	IN
cord-259603-bh198xgl	1033	26	the	the	DT
cord-259603-bh198xgl	1033	27	arterivirus	arterivirus	NNP
cord-259603-bh198xgl	1033	28	life	life	NNP
cord-259603-bh198xgl	1033	29	cycle	cycle	NN
cord-259603-bh198xgl	1033	30	Inhibition	Inhibition	NNP
cord-259603-bh198xgl	1033	31	of	of	IN
cord-259603-bh198xgl	1033	32	human	human	JJ
cord-259603-bh198xgl	1033	33	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1034	1	NL63	nl63	JJ
cord-259603-bh198xgl	1034	2	infection	infection	NN
cord-259603-bh198xgl	1034	3	at	at	IN
cord-259603-bh198xgl	1034	4	early	early	JJ
cord-259603-bh198xgl	1034	5	stages	stage	NNS
cord-259603-bh198xgl	1034	6	of	of	IN
cord-259603-bh198xgl	1034	7	the	the	DT
cord-259603-bh198xgl	1034	8	replication	replication	NN
cord-259603-bh198xgl	1034	9	cycle	cycle	NN
cord-259603-bh198xgl	1034	10	The	the	DT
cord-259603-bh198xgl	1034	11	novel	novel	JJ
cord-259603-bh198xgl	1034	12	human	human	NN
cord-259603-bh198xgl	1034	13	coronaviruses	coronaviruse	NNS
cord-259603-bh198xgl	1035	1	NL63	NL63	NNP
cord-259603-bh198xgl	1035	2	and	and	CC
cord-259603-bh198xgl	1035	3	HKU1	HKU1	NNP
cord-259603-bh198xgl	1036	1	Ribonuclease	Ribonuclease	NNP
cord-259603-bh198xgl	1036	2	A	a	DT
cord-259603-bh198xgl	1036	3	Severe	severe	JJ
cord-259603-bh198xgl	1036	4	acute	acute	JJ
cord-259603-bh198xgl	1036	5	respiratory	respiratory	JJ
cord-259603-bh198xgl	1036	6	syndrome	syndrome	NN
cord-259603-bh198xgl	1036	7	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1036	8	papain	papain	NN
cord-259603-bh198xgl	1036	9	-	-	HYPH
cord-259603-bh198xgl	1036	10	like	like	JJ
cord-259603-bh198xgl	1036	11	protease	protease	NN
cord-259603-bh198xgl	1036	12	:	:	:
cord-259603-bh198xgl	1036	13	structure	structure	NN
cord-259603-bh198xgl	1036	14	of	of	IN
cord-259603-bh198xgl	1036	15	a	a	DT
cord-259603-bh198xgl	1036	16	viral	viral	JJ
cord-259603-bh198xgl	1036	17	deubiquitinating	deubiquitinating	NN
cord-259603-bh198xgl	1036	18	enzyme	enzyme	NN
cord-259603-bh198xgl	1037	1	The	the	DT
cord-259603-bh198xgl	1037	2	structure	structure	NN
cord-259603-bh198xgl	1037	3	of	of	IN
cord-259603-bh198xgl	1037	4	the	the	DT
cord-259603-bh198xgl	1037	5	endoribonuclease	endoribonuclease	NNP
cord-259603-bh198xgl	1037	6	XendoU	xendou	NN
cord-259603-bh198xgl	1037	7	:	:	:
cord-259603-bh198xgl	1037	8	from	from	IN
cord-259603-bh198xgl	1037	9	small	small	JJ
cord-259603-bh198xgl	1037	10	nucleolar	nucleolar	NNS
cord-259603-bh198xgl	1037	11	RNA	RNA	NNP
cord-259603-bh198xgl	1037	12	processing	processing	NN
cord-259603-bh198xgl	1037	13	to	to	IN
cord-259603-bh198xgl	1037	14	severe	severe	JJ
cord-259603-bh198xgl	1037	15	acute	acute	JJ
cord-259603-bh198xgl	1037	16	respiratory	respiratory	JJ
cord-259603-bh198xgl	1037	17	syndrome	syndrome	NN
cord-259603-bh198xgl	1037	18	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1037	19	replication	replication	NN
cord-259603-bh198xgl	1037	20	Middle	Middle	NNP
cord-259603-bh198xgl	1037	21	East	East	NNP
cord-259603-bh198xgl	1037	22	respiratory	respiratory	JJ
cord-259603-bh198xgl	1037	23	syndrome	syndrome	NN
cord-259603-bh198xgl	1037	24	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1037	25	neutralising	neutralise	VBG
cord-259603-bh198xgl	1037	26	serum	serum	NN
cord-259603-bh198xgl	1037	27	antibodies	antibody	NNS
cord-259603-bh198xgl	1037	28	in	in	IN
cord-259603-bh198xgl	1037	29	dromedary	dromedary	NN
cord-259603-bh198xgl	1037	30	camels	camel	NNS
cord-259603-bh198xgl	1037	31	:	:	:
cord-259603-bh198xgl	1037	32	a	a	DT
cord-259603-bh198xgl	1037	33	comparative	comparative	JJ
cord-259603-bh198xgl	1037	34	serological	serological	JJ
cord-259603-bh198xgl	1037	35	study	study	NN
cord-259603-bh198xgl	1037	36	Crystal	Crystal	NNP
cord-259603-bh198xgl	1037	37	structure	structure	NN
cord-259603-bh198xgl	1037	38	and	and	CC
cord-259603-bh198xgl	1037	39	mechanistic	mechanistic	JJ
cord-259603-bh198xgl	1037	40	determinants	determinant	NNS
cord-259603-bh198xgl	1037	41	of	of	IN
cord-259603-bh198xgl	1037	42	SARS	SARS	NNP
cord-259603-bh198xgl	1037	43	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1037	44	nonstructural	nonstructural	JJ
cord-259603-bh198xgl	1037	45	protein	protein	NN
cord-259603-bh198xgl	1037	46	15	15	CD
cord-259603-bh198xgl	1037	47	define	define	VB
cord-259603-bh198xgl	1037	48	an	an	DT
cord-259603-bh198xgl	1037	49	endoribonuclease	endoribonuclease	NN
cord-259603-bh198xgl	1037	50	family	family	NN
cord-259603-bh198xgl	1037	51	Deciphering	decipher	VBG
cord-259603-bh198xgl	1037	52	key	key	JJ
cord-259603-bh198xgl	1037	53	features	feature	NNS
cord-259603-bh198xgl	1037	54	in	in	IN
cord-259603-bh198xgl	1037	55	protein	protein	NN
cord-259603-bh198xgl	1037	56	structures	structure	NNS
cord-259603-bh198xgl	1037	57	with	with	IN
cord-259603-bh198xgl	1037	58	the	the	DT
cord-259603-bh198xgl	1037	59	new	new	JJ
cord-259603-bh198xgl	1037	60	ENDscript	ENDscript	NNP
cord-259603-bh198xgl	1037	61	server	server	NN
cord-259603-bh198xgl	1037	62	Endoplasmic	Endoplasmic	NNP
cord-259603-bh198xgl	1037	63	reticulum	reticulum	NN
cord-259603-bh198xgl	1037	64	:	:	:
cord-259603-bh198xgl	1037	65	the	the	DT
cord-259603-bh198xgl	1037	66	favorite	favorite	JJ
cord-259603-bh198xgl	1037	67	intracellular	intracellular	JJ
cord-259603-bh198xgl	1037	68	niche	niche	NN
cord-259603-bh198xgl	1037	69	for	for	IN
cord-259603-bh198xgl	1037	70	viral	viral	JJ
cord-259603-bh198xgl	1037	71	replication	replication	NN
cord-259603-bh198xgl	1037	72	and	and	CC
cord-259603-bh198xgl	1037	73	assembly	assembly	NN
cord-259603-bh198xgl	1037	74	Animal	Animal	NNP
cord-259603-bh198xgl	1037	75	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1037	76	vaccines	vaccine	NNS
cord-259603-bh198xgl	1037	77	:	:	:
cord-259603-bh198xgl	1037	78	lessons	lesson	NNS
cord-259603-bh198xgl	1037	79	for	for	IN
cord-259603-bh198xgl	1037	80	SARS	SARS	NNP
cord-259603-bh198xgl	1037	81	Viral	Viral	NNP
cord-259603-bh198xgl	1037	82	mutation	mutation	NN
cord-259603-bh198xgl	1037	83	rates	rate	NNS
cord-259603-bh198xgl	1038	1	Coronaviruses	coronaviruse	NNS
cord-259603-bh198xgl	1038	2	use	use	VBP
cord-259603-bh198xgl	1038	3	discontinuous	discontinuous	JJ
cord-259603-bh198xgl	1038	4	extension	extension	NN
cord-259603-bh198xgl	1038	5	for	for	IN
cord-259603-bh198xgl	1038	6	synthesis	synthesis	NN
cord-259603-bh198xgl	1038	7	of	of	IN
cord-259603-bh198xgl	1038	8	subgenome	subgenome	NN
cord-259603-bh198xgl	1038	9	-	-	HYPH
cord-259603-bh198xgl	1038	10	length	length	NN
cord-259603-bh198xgl	1038	11	negative	negative	JJ
cord-259603-bh198xgl	1038	12	strands	strand	NNS
cord-259603-bh198xgl	1038	13	Functional	functional	JJ
cord-259603-bh198xgl	1038	14	and	and	CC
cord-259603-bh198xgl	1038	15	genetic	genetic	JJ
cord-259603-bh198xgl	1038	16	analysis	analysis	NN
cord-259603-bh198xgl	1038	17	of	of	IN
cord-259603-bh198xgl	1038	18	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1038	19	replicase	replicase	NN
cord-259603-bh198xgl	1038	20	-	-	HYPH
cord-259603-bh198xgl	1038	21	transcriptase	transcriptase	NN
cord-259603-bh198xgl	1038	22	proteins	protein	NNS
cord-259603-bh198xgl	1039	1	A	a	DT
cord-259603-bh198xgl	1039	2	contemporary	contemporary	JJ
cord-259603-bh198xgl	1039	3	view	view	NN
cord-259603-bh198xgl	1039	4	of	of	IN
cord-259603-bh198xgl	1039	5	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1039	6	transcription	transcription	NN
cord-259603-bh198xgl	1039	7	Identification	identification	NN
cord-259603-bh198xgl	1039	8	of	of	IN
cord-259603-bh198xgl	1039	9	the	the	DT
cord-259603-bh198xgl	1039	10	epsilon	epsilon	NN
cord-259603-bh198xgl	1039	11	-	-	HYPH
cord-259603-bh198xgl	1039	12	subunit	subunit	NN
cord-259603-bh198xgl	1039	13	of	of	IN
cord-259603-bh198xgl	1039	14	Escherichia	Escherichia	NNP
cord-259603-bh198xgl	1039	15	coli	coli	VBZ
cord-259603-bh198xgl	1039	16	DNA	dna	NN
cord-259603-bh198xgl	1039	17	polymerase	polymerase	NN
cord-259603-bh198xgl	1039	18	III	iii	CD
cord-259603-bh198xgl	1039	19	holoenzyme	holoenzyme	NNS
cord-259603-bh198xgl	1039	20	as	as	IN
cord-259603-bh198xgl	1039	21	the	the	DT
cord-259603-bh198xgl	1039	22	dnaQ	dnaQ	NNP
cord-259603-bh198xgl	1039	23	gene	gene	NN
cord-259603-bh198xgl	1039	24	product	product	NN
cord-259603-bh198xgl	1039	25	:	:	:
cord-259603-bh198xgl	1039	26	a	a	DT
cord-259603-bh198xgl	1039	27	fidelity	fidelity	NN
cord-259603-bh198xgl	1039	28	subunit	subunit	NN
cord-259603-bh198xgl	1039	29	for	for	IN
cord-259603-bh198xgl	1039	30	DNA	dna	NN
cord-259603-bh198xgl	1039	31	replication	replication	NN
cord-259603-bh198xgl	1040	1	Re	Re	VBG
cord-259603-bh198xgl	1040	2	-	-	VBG
cord-259603-bh198xgl	1040	3	capping	cap	VBG
cord-259603-bh198xgl	1040	4	the	the	DT
cord-259603-bh198xgl	1040	5	message	message	NN
cord-259603-bh198xgl	1040	6	A	a	DT
cord-259603-bh198xgl	1040	7	conserved	conserve	VBN
cord-259603-bh198xgl	1040	8	histidine	histidine	NN
cord-259603-bh198xgl	1040	9	in	in	IN
cord-259603-bh198xgl	1040	10	the	the	DT
cord-259603-bh198xgl	1040	11	RNA	RNA	NNP
cord-259603-bh198xgl	1040	12	sensor	sensor	NN
cord-259603-bh198xgl	1040	13	RIG	rig	NN
cord-259603-bh198xgl	1040	14	-	-	:
cord-259603-bh198xgl	1040	15	I	-PRON-	PRP
cord-259603-bh198xgl	1040	16	controls	control	VBZ
cord-259603-bh198xgl	1040	17	immune	immune	JJ
cord-259603-bh198xgl	1040	18	tolerance	tolerance	NN
cord-259603-bh198xgl	1040	19	to	to	IN
cord-259603-bh198xgl	1040	20	N1	N1	NNP
cord-259603-bh198xgl	1040	21	-	-	HYPH
cord-259603-bh198xgl	1040	22	2	2	CD
cord-259603-bh198xgl	1040	23	0	0	CD
cord-259603-bh198xgl	1040	24	O	o	NN
cord-259603-bh198xgl	1040	25	-	-	HYPH
cord-259603-bh198xgl	1040	26	methylated	methylated	JJ
cord-259603-bh198xgl	1040	27	self	self	NN
cord-259603-bh198xgl	1040	28	RNA	RNA	NNP
cord-259603-bh198xgl	1040	29	Coronavirus	Coronavirus	NNP
cord-259603-bh198xgl	1040	30	subgenomic	subgenomic	JJ
cord-259603-bh198xgl	1040	31	minus	minus	JJ
cord-259603-bh198xgl	1040	32	-	-	HYPH
cord-259603-bh198xgl	1040	33	strand	strand	NN
cord-259603-bh198xgl	1040	34	RNAs	rna	NNS
cord-259603-bh198xgl	1040	35	and	and	CC
cord-259603-bh198xgl	1040	36	the	the	DT
cord-259603-bh198xgl	1040	37	potential	potential	NN
cord-259603-bh198xgl	1040	38	for	for	IN
cord-259603-bh198xgl	1040	39	mRNA	mRNA	NNP
cord-259603-bh198xgl	1040	40	replicons	replicons	NNPS
cord-259603-bh198xgl	1040	41	Insights	Insights	NNP
cord-259603-bh198xgl	1040	42	into	into	IN
cord-259603-bh198xgl	1040	43	RNA	RNA	NNP
cord-259603-bh198xgl	1040	44	synthesis	synthesis	NN
cord-259603-bh198xgl	1040	45	,	,	,
cord-259603-bh198xgl	1040	46	capping	capping	NN
cord-259603-bh198xgl	1040	47	,	,	,
cord-259603-bh198xgl	1040	48	and	and	CC
cord-259603-bh198xgl	1040	49	proofreading	proofreading	NN
cord-259603-bh198xgl	1040	50	mechanisms	mechanism	NNS
cord-259603-bh198xgl	1040	51	of	of	IN
cord-259603-bh198xgl	1040	52	SARS	SARS	NNP
cord-259603-bh198xgl	1040	53	-	-	HYPH
cord-259603-bh198xgl	1040	54	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1040	55	Homology	homology	NN
cord-259603-bh198xgl	1040	56	-	-	HYPH
cord-259603-bh198xgl	1040	57	based	base	VBN
cord-259603-bh198xgl	1040	58	identification	identification	NN
cord-259603-bh198xgl	1040	59	of	of	IN
cord-259603-bh198xgl	1040	60	a	a	DT
cord-259603-bh198xgl	1040	61	mutation	mutation	NN
cord-259603-bh198xgl	1040	62	in	in	IN
cord-259603-bh198xgl	1040	63	the	the	DT
cord-259603-bh198xgl	1040	64	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1040	65	RNA	rna	NN
cord-259603-bh198xgl	1040	66	-	-	HYPH
cord-259603-bh198xgl	1040	67	dependent	dependent	JJ
cord-259603-bh198xgl	1040	68	RNA	RNA	NNP
cord-259603-bh198xgl	1040	69	polymerase	polymerase	NN
cord-259603-bh198xgl	1040	70	that	that	WDT
cord-259603-bh198xgl	1040	71	confers	confer	VBZ
cord-259603-bh198xgl	1040	72	resistance	resistance	NN
cord-259603-bh198xgl	1040	73	to	to	IN
cord-259603-bh198xgl	1040	74	multiple	multiple	JJ
cord-259603-bh198xgl	1040	75	mutagens	mutagen	NNS
cord-259603-bh198xgl	1041	1	The	the	DT
cord-259603-bh198xgl	1041	2	human	human	JJ
cord-259603-bh198xgl	1041	3	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1041	4	229E	229e	CD
cord-259603-bh198xgl	1041	5	superfamily	superfamily	NN
cord-259603-bh198xgl	1041	6	1	1	CD
cord-259603-bh198xgl	1041	7	helicase	helicase	NNP
cord-259603-bh198xgl	1041	8	has	have	VBZ
cord-259603-bh198xgl	1041	9	RNA	RNA	NNP
cord-259603-bh198xgl	1041	10	and	and	CC
cord-259603-bh198xgl	1041	11	DNA	dna	NN
cord-259603-bh198xgl	1041	12	duplex	duplex	NN
cord-259603-bh198xgl	1041	13	-	-	HYPH
cord-259603-bh198xgl	1041	14	unwinding	unwind	VBG
cord-259603-bh198xgl	1041	15	activities	activity	NNS
cord-259603-bh198xgl	1041	16	with	with	IN
cord-259603-bh198xgl	1041	17	5	5	CD
cord-259603-bh198xgl	1041	18	0	0	CD
cord-259603-bh198xgl	1041	19	-to-3	-to-3	CD
cord-259603-bh198xgl	1041	20	0	0	CD
cord-259603-bh198xgl	1041	21	polarity	polarity	NN
cord-259603-bh198xgl	1041	22	Biochemical	biochemical	JJ
cord-259603-bh198xgl	1041	23	characterization	characterization	NN
cord-259603-bh198xgl	1041	24	of	of	IN
cord-259603-bh198xgl	1041	25	the	the	DT
cord-259603-bh198xgl	1041	26	equine	equine	JJ
cord-259603-bh198xgl	1041	27	arteritis	arteritis	NN
cord-259603-bh198xgl	1041	28	virus	virus	NN
cord-259603-bh198xgl	1041	29	helicase	helicase	NNP
cord-259603-bh198xgl	1041	30	suggests	suggest	VBZ
cord-259603-bh198xgl	1041	31	a	a	DT
cord-259603-bh198xgl	1041	32	close	close	JJ
cord-259603-bh198xgl	1041	33	functional	functional	JJ
cord-259603-bh198xgl	1041	34	relationship	relationship	NN
cord-259603-bh198xgl	1041	35	between	between	IN
cord-259603-bh198xgl	1041	36	arterivirus	arterivirus	NN
cord-259603-bh198xgl	1041	37	and	and	CC
cord-259603-bh198xgl	1041	38	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1041	39	helicases	helicase	NNS
cord-259603-bh198xgl	1041	40	A	a	DT
cord-259603-bh198xgl	1041	41	complex	complex	JJ
cord-259603-bh198xgl	1041	42	zinc	zinc	NN
cord-259603-bh198xgl	1041	43	finger	finger	NN
cord-259603-bh198xgl	1041	44	controls	control	VBZ
cord-259603-bh198xgl	1041	45	the	the	DT
cord-259603-bh198xgl	1041	46	enzymatic	enzymatic	JJ
cord-259603-bh198xgl	1041	47	activities	activity	NNS
cord-259603-bh198xgl	1041	48	of	of	IN
cord-259603-bh198xgl	1041	49	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	1041	50	helicases	helicase	NNS
cord-259603-bh198xgl	1041	51	Capping	cap	VBG
cord-259603-bh198xgl	1041	52	of	of	IN
cord-259603-bh198xgl	1041	53	eucaryotic	eucaryotic	JJ
cord-259603-bh198xgl	1041	54	mRNAs	mrnas	XX
cord-259603-bh198xgl	1042	1	Fast	fast	RB
cord-259603-bh198xgl	1042	2	,	,	,
cord-259603-bh198xgl	1042	3	scalable	scalable	JJ
cord-259603-bh198xgl	1042	4	generation	generation	NN
cord-259603-bh198xgl	1042	5	of	of	IN
cord-259603-bh198xgl	1042	6	high	high	JJ
cord-259603-bh198xgl	1042	7	-	-	HYPH
cord-259603-bh198xgl	1042	8	quality	quality	NN
cord-259603-bh198xgl	1042	9	protein	protein	NN
cord-259603-bh198xgl	1042	10	multiple	multiple	JJ
cord-259603-bh198xgl	1042	11	sequence	sequence	NN
cord-259603-bh198xgl	1042	12	alignments	alignment	NNS
cord-259603-bh198xgl	1042	13	using	use	VBG
cord-259603-bh198xgl	1042	14	clustal	clustal	NNP
cord-259603-bh198xgl	1042	15	omega	omega	NNP
cord-259603-bh198xgl	1042	16	Structure	Structure	NNP
cord-259603-bh198xgl	1042	17	and	and	CC
cord-259603-bh198xgl	1042	18	mechanism	mechanism	NN
cord-259603-bh198xgl	1042	19	of	of	IN
cord-259603-bh198xgl	1042	20	helicases	helicase	NNS
cord-259603-bh198xgl	1042	21	and	and	CC
cord-259603-bh198xgl	1042	22	nucleic	nucleic	JJ
cord-259603-bh198xgl	1042	23	acid	acid	NN
cord-259603-bh198xgl	1042	24	translocases	translocase	NNS
cord-259603-bh198xgl	1042	25	Coronaviruses	Coronaviruses	NNP
cord-259603-bh198xgl	1043	1	lacking	lack	VBG
cord-259603-bh198xgl	1044	1	exoribonuclease	exoribonuclease	NNP
cord-259603-bh198xgl	1044	2	activity	activity	NN
cord-259603-bh198xgl	1044	3	are	be	VBP
cord-259603-bh198xgl	1044	4	susceptible	susceptible	JJ
cord-259603-bh198xgl	1044	5	to	to	IN
cord-259603-bh198xgl	1044	6	lethal	lethal	JJ
cord-259603-bh198xgl	1044	7	mutagenesis	mutagenesis	NN
cord-259603-bh198xgl	1044	8	:	:	:
cord-259603-bh198xgl	1044	9	evidence	evidence	NN
cord-259603-bh198xgl	1044	10	for	for	IN
cord-259603-bh198xgl	1044	11	proofreading	proofread	VBG
cord-259603-bh198xgl	1044	12	and	and	CC
cord-259603-bh198xgl	1044	13	potential	potential	JJ
cord-259603-bh198xgl	1044	14	therapeutics	therapeutic	NNS
cord-259603-bh198xgl	1044	15	Thinking	think	VBG
cord-259603-bh198xgl	1044	16	outside	outside	IN
cord-259603-bh198xgl	1044	17	the	the	DT
cord-259603-bh198xgl	1044	18	triangle	triangle	NN
cord-259603-bh198xgl	1044	19	:	:	:
cord-259603-bh198xgl	1044	20	replication	replication	NN
cord-259603-bh198xgl	1044	21	fidelity	fidelity	NN
cord-259603-bh198xgl	1044	22	of	of	IN
cord-259603-bh198xgl	1044	23	the	the	DT
cord-259603-bh198xgl	1044	24	largest	large	JJS
cord-259603-bh198xgl	1044	25	RNA	RNA	NNP
cord-259603-bh198xgl	1044	26	viruses	virus	NNS
cord-259603-bh198xgl	1045	1	The	the	DT
cord-259603-bh198xgl	1045	2	carboxyl	carboxyl	NN
cord-259603-bh198xgl	1045	3	-	-	HYPH
cord-259603-bh198xgl	1045	4	terminal	terminal	NN
cord-259603-bh198xgl	1045	5	part	part	NN
cord-259603-bh198xgl	1045	6	of	of	IN
cord-259603-bh198xgl	1045	7	the	the	DT
cord-259603-bh198xgl	1045	8	putative	putative	JJ
cord-259603-bh198xgl	1045	9	Berne	Berne	NNP
cord-259603-bh198xgl	1045	10	virus	virus	NN
cord-259603-bh198xgl	1045	11	polymerase	polymerase	NN
cord-259603-bh198xgl	1045	12	is	be	VBZ
cord-259603-bh198xgl	1045	13	expressed	express	VBN
cord-259603-bh198xgl	1045	14	by	by	IN
cord-259603-bh198xgl	1045	15	ribosomal	ribosomal	JJ
cord-259603-bh198xgl	1045	16	frameshifting	frameshifting	NN
cord-259603-bh198xgl	1045	17	and	and	CC
cord-259603-bh198xgl	1045	18	contains	contain	VBZ
cord-259603-bh198xgl	1045	19	sequence	sequence	NN
cord-259603-bh198xgl	1045	20	motifs	motif	NNS
cord-259603-bh198xgl	1045	21	which	which	WDT
cord-259603-bh198xgl	1045	22	indicate	indicate	VBP
cord-259603-bh198xgl	1045	23	that	that	IN
cord-259603-bh198xgl	1045	24	toro	toro	NN
cord-259603-bh198xgl	1045	25	-	-	HYPH
cord-259603-bh198xgl	1045	26	and	and	CC
cord-259603-bh198xgl	1045	27	coronaviruses	coronaviruse	NNS
cord-259603-bh198xgl	1045	28	are	be	VBP
cord-259603-bh198xgl	1045	29	evolutionarily	evolutionarily	RB
cord-259603-bh198xgl	1045	30	related	relate	VBN
cord-259603-bh198xgl	1045	31	The	the	DT
cord-259603-bh198xgl	1045	32	coronaviruslike	coronaviruslike	JJ
cord-259603-bh198xgl	1045	33	superfamily	superfamily	NN
cord-259603-bh198xgl	1045	34	Unique	Unique	NNP
cord-259603-bh198xgl	1045	35	and	and	CC
cord-259603-bh198xgl	1045	36	conserved	conserve	VBN
cord-259603-bh198xgl	1045	37	features	feature	NNS
cord-259603-bh198xgl	1045	38	of	of	IN
cord-259603-bh198xgl	1045	39	genome	genome	NN
cord-259603-bh198xgl	1045	40	and	and	CC
cord-259603-bh198xgl	1045	41	proteome	proteome	NN
cord-259603-bh198xgl	1045	42	of	of	IN
cord-259603-bh198xgl	1045	43	SARS	SARS	NNP
cord-259603-bh198xgl	1045	44	-	-	HYPH
cord-259603-bh198xgl	1045	45	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1045	46	,	,	,
cord-259603-bh198xgl	1045	47	an	an	DT
cord-259603-bh198xgl	1045	48	early	early	JJ
cord-259603-bh198xgl	1045	49	split	split	NN
cord-259603-bh198xgl	1045	50	-	-	HYPH
cord-259603-bh198xgl	1045	51	off	off	NN
cord-259603-bh198xgl	1045	52	from	from	IN
cord-259603-bh198xgl	1045	53	the	the	DT
cord-259603-bh198xgl	1045	54	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1045	55	group	group	NN
cord-259603-bh198xgl	1045	56	2	2	CD
cord-259603-bh198xgl	1045	57	lineage	lineage	NN
cord-259603-bh198xgl	1045	58	RNA	RNA	NNP
cord-259603-bh198xgl	1045	59	-	-	HYPH
cord-259603-bh198xgl	1045	60	RNA	RNA	NNP
cord-259603-bh198xgl	1045	61	and	and	CC
cord-259603-bh198xgl	1045	62	RNA	RNA	NNP
cord-259603-bh198xgl	1045	63	-	-	HYPH
cord-259603-bh198xgl	1045	64	protein	protein	NN
cord-259603-bh198xgl	1045	65	interactions	interaction	NNS
cord-259603-bh198xgl	1045	66	in	in	IN
cord-259603-bh198xgl	1045	67	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1045	68	replication	replication	NN
cord-259603-bh198xgl	1045	69	and	and	CC
cord-259603-bh198xgl	1045	70	transcription	transcription	NN
cord-259603-bh198xgl	1045	71	Crosshost	Crosshost	NNP
cord-259603-bh198xgl	1045	72	evolution	evolution	NN
cord-259603-bh198xgl	1045	73	of	of	IN
cord-259603-bh198xgl	1045	74	severe	severe	JJ
cord-259603-bh198xgl	1045	75	acute	acute	JJ
cord-259603-bh198xgl	1045	76	respiratory	respiratory	JJ
cord-259603-bh198xgl	1045	77	syndrome	syndrome	NN
cord-259603-bh198xgl	1045	78	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1045	79	in	in	IN
cord-259603-bh198xgl	1045	80	palm	palm	NN
cord-259603-bh198xgl	1045	81	civet	civet	NN
cord-259603-bh198xgl	1045	82	and	and	CC
cord-259603-bh198xgl	1045	83	human	human	NN
cord-259603-bh198xgl	1045	84	A	a	NN
cord-259603-bh198xgl	1046	1	general	general	JJ
cord-259603-bh198xgl	1046	2	two	two	CD
cord-259603-bh198xgl	1046	3	-	-	HYPH
cord-259603-bh198xgl	1046	4	metal	metal	NN
cord-259603-bh198xgl	1046	5	-	-	HYPH
cord-259603-bh198xgl	1046	6	ion	ion	NN
cord-259603-bh198xgl	1046	7	mechanism	mechanism	NN
cord-259603-bh198xgl	1046	8	for	for	IN
cord-259603-bh198xgl	1046	9	catalytic	catalytic	JJ
cord-259603-bh198xgl	1046	10	RNA	RNA	NNP
cord-259603-bh198xgl	1046	11	Recent	Recent	NNP
cord-259603-bh198xgl	1046	12	advances	advance	NNS
cord-259603-bh198xgl	1046	13	in	in	IN
cord-259603-bh198xgl	1046	14	targeting	target	VBG
cord-259603-bh198xgl	1046	15	viral	viral	JJ
cord-259603-bh198xgl	1046	16	proteases	protease	NNS
cord-259603-bh198xgl	1046	17	for	for	IN
cord-259603-bh198xgl	1046	18	the	the	DT
cord-259603-bh198xgl	1046	19	discovery	discovery	NN
cord-259603-bh198xgl	1046	20	of	of	IN
cord-259603-bh198xgl	1046	21	novel	novel	JJ
cord-259603-bh198xgl	1046	22	antivirals	antiviral	NNS
cord-259603-bh198xgl	1046	23	Dodecamer	Dodecamer	NNP
cord-259603-bh198xgl	1046	24	structure	structure	NN
cord-259603-bh198xgl	1046	25	of	of	IN
cord-259603-bh198xgl	1046	26	severe	severe	JJ
cord-259603-bh198xgl	1046	27	acute	acute	JJ
cord-259603-bh198xgl	1046	28	respiratory	respiratory	JJ
cord-259603-bh198xgl	1046	29	syndrome	syndrome	NN
cord-259603-bh198xgl	1046	30	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1046	31	nonstructural	nonstructural	JJ
cord-259603-bh198xgl	1046	32	protein	protein	NN
cord-259603-bh198xgl	1046	33	nsp10	nsp10	ADD
cord-259603-bh198xgl	1046	34	SARS	SARS	NNP
cord-259603-bh198xgl	1046	35	-	-	HYPH
cord-259603-bh198xgl	1046	36	CoV	CoV	NNP
cord-259603-bh198xgl	1046	37	ORF1b	ORF1b	NNP
cord-259603-bh198xgl	1046	38	-	-	HYPH
cord-259603-bh198xgl	1046	39	encoded	encode	VBN
cord-259603-bh198xgl	1046	40	nonstructural	nonstructural	JJ
cord-259603-bh198xgl	1046	41	proteins	protein	NNS
cord-259603-bh198xgl	1047	1	12	12	CD
cord-259603-bh198xgl	1047	2	-	-	SYM
cord-259603-bh198xgl	1047	3	16	16	CD
cord-259603-bh198xgl	1047	4	:	:	:
cord-259603-bh198xgl	1047	5	replicative	replicative	JJ
cord-259603-bh198xgl	1047	6	enzymes	enzyme	NNS
cord-259603-bh198xgl	1047	7	as	as	IN
cord-259603-bh198xgl	1047	8	antiviral	antiviral	JJ
cord-259603-bh198xgl	1047	9	targets	target	NNS
cord-259603-bh198xgl	1047	10	One	one	CD
cord-259603-bh198xgl	1047	11	severe	severe	JJ
cord-259603-bh198xgl	1047	12	acute	acute	JJ
cord-259603-bh198xgl	1047	13	respiratory	respiratory	JJ
cord-259603-bh198xgl	1047	14	syndrome	syndrome	NN
cord-259603-bh198xgl	1047	15	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1047	16	protein	protein	NN
cord-259603-bh198xgl	1047	17	complex	complex	NN
cord-259603-bh198xgl	1047	18	integrates	integrate	VBZ
cord-259603-bh198xgl	1047	19	processive	processive	JJ
cord-259603-bh198xgl	1047	20	RNA	RNA	NNP
cord-259603-bh198xgl	1047	21	polymerase	polymerase	NN
cord-259603-bh198xgl	1047	22	and	and	CC
cord-259603-bh198xgl	1047	23	exonuclease	exonuclease	NN
cord-259603-bh198xgl	1047	24	activities	activity	NNS
cord-259603-bh198xgl	1047	25	Yeast	yeast	NN
cord-259603-bh198xgl	1047	26	-	-	HYPH
cord-259603-bh198xgl	1047	27	based	base	VBN
cord-259603-bh198xgl	1047	28	assays	assay	NNS
cord-259603-bh198xgl	1047	29	for	for	IN
cord-259603-bh198xgl	1047	30	the	the	DT
cord-259603-bh198xgl	1047	31	high	high	JJ
cord-259603-bh198xgl	1047	32	-	-	HYPH
cord-259603-bh198xgl	1047	33	throughput	throughput	NN
cord-259603-bh198xgl	1047	34	screening	screening	NN
cord-259603-bh198xgl	1047	35	of	of	IN
cord-259603-bh198xgl	1047	36	inhibitors	inhibitor	NNS
cord-259603-bh198xgl	1047	37	of	of	IN
cord-259603-bh198xgl	1047	38	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1047	39	RNA	RNA	NNP
cord-259603-bh198xgl	1047	40	cap	cap	NN
cord-259603-bh198xgl	1047	41	guanine	guanine	NN
cord-259603-bh198xgl	1047	42	-	-	HYPH
cord-259603-bh198xgl	1047	43	N7-methyltransferase	n7-methyltransferase	NN
cord-259603-bh198xgl	1048	1	The	the	DT
cord-259603-bh198xgl	1048	2	nsp9	nsp9	DT
cord-259603-bh198xgl	1048	3	replicase	replicase	NN
cord-259603-bh198xgl	1048	4	protein	protein	NN
cord-259603-bh198xgl	1048	5	of	of	IN
cord-259603-bh198xgl	1048	6	SARS	SARS	NNP
cord-259603-bh198xgl	1048	7	-	-	HYPH
cord-259603-bh198xgl	1048	8	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1048	9	,	,	,
cord-259603-bh198xgl	1048	10	structure	structure	NN
cord-259603-bh198xgl	1048	11	and	and	CC
cord-259603-bh198xgl	1048	12	functional	functional	JJ
cord-259603-bh198xgl	1048	13	insights	insight	NNS
cord-259603-bh198xgl	1049	1	The	the	DT
cord-259603-bh198xgl	1049	2	severe	severe	JJ
cord-259603-bh198xgl	1049	3	acute	acute	JJ
cord-259603-bh198xgl	1049	4	respiratory	respiratory	JJ
cord-259603-bh198xgl	1049	5	syndrome	syndrome	NN
cord-259603-bh198xgl	1049	6	(	(	-LRB-
cord-259603-bh198xgl	1049	7	SARS	SARS	NNP
cord-259603-bh198xgl	1049	8	)	)	-RRB-
cord-259603-bh198xgl	1049	9	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1050	1	NTPase	NTPase	NNP
cord-259603-bh198xgl	1050	2	/	/	SYM
cord-259603-bh198xgl	1050	3	helicase	helicase	NNP
cord-259603-bh198xgl	1050	4	belongs	belong	VBZ
cord-259603-bh198xgl	1050	5	to	to	IN
cord-259603-bh198xgl	1050	6	a	a	DT
cord-259603-bh198xgl	1050	7	distinct	distinct	JJ
cord-259603-bh198xgl	1050	8	class	class	NN
cord-259603-bh198xgl	1050	9	of	of	IN
cord-259603-bh198xgl	1050	10	5	5	CD
cord-259603-bh198xgl	1050	11	0	0	CD
cord-259603-bh198xgl	1050	12	to	to	IN
cord-259603-bh198xgl	1050	13	3	3	CD
cord-259603-bh198xgl	1050	14	0	0	CD
cord-259603-bh198xgl	1050	15	viral	viral	JJ
cord-259603-bh198xgl	1050	16	helicases	helicase	NNS
cord-259603-bh198xgl	1051	1	The	the	DT
cord-259603-bh198xgl	1051	2	adamantane	adamantane	NN
cord-259603-bh198xgl	1051	3	-	-	HYPH
cord-259603-bh198xgl	1051	4	derived	derive	VBN
cord-259603-bh198xgl	1051	5	bananins	bananin	NNS
cord-259603-bh198xgl	1051	6	are	be	VBP
cord-259603-bh198xgl	1051	7	potent	potent	JJ
cord-259603-bh198xgl	1051	8	inhibitors	inhibitor	NNS
cord-259603-bh198xgl	1051	9	of	of	IN
cord-259603-bh198xgl	1051	10	the	the	DT
cord-259603-bh198xgl	1051	11	helicase	helicase	NN
cord-259603-bh198xgl	1051	12	activities	activity	NNS
cord-259603-bh198xgl	1051	13	and	and	CC
cord-259603-bh198xgl	1051	14	replication	replication	NN
cord-259603-bh198xgl	1051	15	of	of	IN
cord-259603-bh198xgl	1051	16	SARS	SARS	NNP
cord-259603-bh198xgl	1051	17	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1051	18	Common	common	JJ
cord-259603-bh198xgl	1051	19	and	and	CC
cord-259603-bh198xgl	1051	20	unique	unique	JJ
cord-259603-bh198xgl	1051	21	features	feature	NNS
cord-259603-bh198xgl	1051	22	of	of	IN
cord-259603-bh198xgl	1051	23	viral	viral	JJ
cord-259603-bh198xgl	1051	24	RNA	rna	NN
cord-259603-bh198xgl	1051	25	-	-	HYPH
cord-259603-bh198xgl	1051	26	dependent	dependent	JJ
cord-259603-bh198xgl	1051	27	polymerases	polymerase	NNS
cord-259603-bh198xgl	1051	28	The	the	DT
cord-259603-bh198xgl	1051	29	RNA	RNA	NNP
cord-259603-bh198xgl	1051	30	polymerase	polymerase	NN
cord-259603-bh198xgl	1051	31	activity	activity	NN
cord-259603-bh198xgl	1051	32	of	of	IN
cord-259603-bh198xgl	1052	1	SARS	SARS	NNP
cord-259603-bh198xgl	1052	2	-	-	HYPH
cord-259603-bh198xgl	1052	3	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1052	4	nsp12	nsp12	CD
cord-259603-bh198xgl	1052	5	is	be	VBZ
cord-259603-bh198xgl	1052	6	primer	primer	NN
cord-259603-bh198xgl	1052	7	dependent	dependent	JJ
cord-259603-bh198xgl	1053	1	The	the	DT
cord-259603-bh198xgl	1053	2	SARS	SARS	NNP
cord-259603-bh198xgl	1053	3	-	-	HYPH
cord-259603-bh198xgl	1053	4	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1053	5	nsp7	nsp7	IN
cord-259603-bh198xgl	1053	6	+	+	CC
cord-259603-bh198xgl	1053	7	nsp8	nsp8	NN
cord-259603-bh198xgl	1053	8	complex	complex	NN
cord-259603-bh198xgl	1053	9	is	be	VBZ
cord-259603-bh198xgl	1053	10	a	a	DT
cord-259603-bh198xgl	1053	11	unique	unique	JJ
cord-259603-bh198xgl	1053	12	multimeric	multimeric	JJ
cord-259603-bh198xgl	1053	13	RNA	RNA	NNP
cord-259603-bh198xgl	1053	14	polymerase	polymerase	NN
cord-259603-bh198xgl	1053	15	capable	capable	JJ
cord-259603-bh198xgl	1053	16	of	of	IN
cord-259603-bh198xgl	1053	17	both	both	DT
cord-259603-bh198xgl	1053	18	de	de	FW
cord-259603-bh198xgl	1053	19	novo	novo	NNP
cord-259603-bh198xgl	1053	20	initiation	initiation	NN
cord-259603-bh198xgl	1053	21	and	and	CC
cord-259603-bh198xgl	1053	22	primer	primer	NN
cord-259603-bh198xgl	1053	23	extension	extension	NN
cord-259603-bh198xgl	1053	24	Nidovirus	Nidovirus	NNP
cord-259603-bh198xgl	1053	25	ribonucleases	ribonuclease	NNS
cord-259603-bh198xgl	1053	26	:	:	:
cord-259603-bh198xgl	1053	27	structures	structure	NNS
cord-259603-bh198xgl	1053	28	and	and	CC
cord-259603-bh198xgl	1053	29	functions	function	NNS
cord-259603-bh198xgl	1053	30	in	in	IN
cord-259603-bh198xgl	1053	31	viral	viral	JJ
cord-259603-bh198xgl	1053	32	replication	replication	NN
cord-259603-bh198xgl	1053	33	Biogenesis	biogenesis	NN
cord-259603-bh198xgl	1053	34	and	and	CC
cord-259603-bh198xgl	1053	35	architecture	architecture	NN
cord-259603-bh198xgl	1053	36	of	of	IN
cord-259603-bh198xgl	1053	37	arterivirus	arterivirus	NN
cord-259603-bh198xgl	1053	38	replication	replication	NN
cord-259603-bh198xgl	1053	39	organelles	organelle	NNS
cord-259603-bh198xgl	1053	40	Initiation	Initiation	NNP
cord-259603-bh198xgl	1053	41	of	of	IN
cord-259603-bh198xgl	1053	42	viral	viral	JJ
cord-259603-bh198xgl	1053	43	RNA	RNA	NNP
cord-259603-bh198xgl	1053	44	-	-	HYPH
cord-259603-bh198xgl	1053	45	dependent	dependent	JJ
cord-259603-bh198xgl	1053	46	RNA	RNA	NNP
cord-259603-bh198xgl	1053	47	polymerization	polymerization	NN
cord-259603-bh198xgl	1054	1	An	an	DT
cord-259603-bh198xgl	1054	2	infectious	infectious	JJ
cord-259603-bh198xgl	1054	3	arterivirus	arterivirus	NN
cord-259603-bh198xgl	1054	4	cDNA	cdna	NN
cord-259603-bh198xgl	1054	5	clone	clone	NN
cord-259603-bh198xgl	1054	6	:	:	:
cord-259603-bh198xgl	1054	7	identification	identification	NN
cord-259603-bh198xgl	1054	8	of	of	IN
cord-259603-bh198xgl	1054	9	a	a	DT
cord-259603-bh198xgl	1054	10	replicase	replicase	NN
cord-259603-bh198xgl	1054	11	point	point	NN
cord-259603-bh198xgl	1054	12	mutation	mutation	NN
cord-259603-bh198xgl	1054	13	that	that	WDT
cord-259603-bh198xgl	1054	14	abolishes	abolish	VBZ
cord-259603-bh198xgl	1054	15	discontinuous	discontinuous	JJ
cord-259603-bh198xgl	1054	16	mRNA	mRNA	NNP
cord-259603-bh198xgl	1054	17	transcription	transcription	NN
cord-259603-bh198xgl	1055	1	The	the	DT
cord-259603-bh198xgl	1055	2	predicted	predict	VBN
cord-259603-bh198xgl	1055	3	metalbinding	metalbinde	VBG
cord-259603-bh198xgl	1055	4	region	region	NN
cord-259603-bh198xgl	1055	5	of	of	IN
cord-259603-bh198xgl	1055	6	the	the	DT
cord-259603-bh198xgl	1055	7	arterivirus	arterivirus	NNP
cord-259603-bh198xgl	1055	8	helicase	helicase	NNP
cord-259603-bh198xgl	1055	9	protein	protein	NN
cord-259603-bh198xgl	1055	10	is	be	VBZ
cord-259603-bh198xgl	1055	11	involved	involve	VBN
cord-259603-bh198xgl	1055	12	in	in	IN
cord-259603-bh198xgl	1055	13	subgenomic	subgenomic	NNP
cord-259603-bh198xgl	1055	14	mRNA	mRNA	NNP
cord-259603-bh198xgl	1055	15	synthesis	synthesis	NNP
cord-259603-bh198xgl	1055	16	,	,	,
cord-259603-bh198xgl	1055	17	genome	genome	NN
cord-259603-bh198xgl	1055	18	replication	replication	NN
cord-259603-bh198xgl	1055	19	,	,	,
cord-259603-bh198xgl	1055	20	and	and	CC
cord-259603-bh198xgl	1055	21	virion	virion	NN
cord-259603-bh198xgl	1055	22	biogenesis	biogenesis	NN
cord-259603-bh198xgl	1056	1	The	the	DT
cord-259603-bh198xgl	1056	2	in	in	FW
cord-259603-bh198xgl	1056	3	vitro	vitro	FW
cord-259603-bh198xgl	1056	4	RNA	rna	NN
cord-259603-bh198xgl	1056	5	synthesizing	synthesize	VBG
cord-259603-bh198xgl	1056	6	activity	activity	NN
cord-259603-bh198xgl	1056	7	of	of	IN
cord-259603-bh198xgl	1056	8	the	the	DT
cord-259603-bh198xgl	1056	9	isolated	isolate	VBN
cord-259603-bh198xgl	1056	10	arterivirus	arterivirus	NN
cord-259603-bh198xgl	1056	11	replication	replication	NN
cord-259603-bh198xgl	1056	12	/	/	SYM
cord-259603-bh198xgl	1056	13	transcription	transcription	NN
cord-259603-bh198xgl	1056	14	complex	complex	NN
cord-259603-bh198xgl	1056	15	is	be	VBZ
cord-259603-bh198xgl	1056	16	dependent	dependent	JJ
cord-259603-bh198xgl	1056	17	on	on	IN
cord-259603-bh198xgl	1056	18	a	a	DT
cord-259603-bh198xgl	1056	19	host	host	NN
cord-259603-bh198xgl	1056	20	factor	factor	NN
cord-259603-bh198xgl	1056	21	Discontinuous	Discontinuous	NNP
cord-259603-bh198xgl	1056	22	and	and	CC
cord-259603-bh198xgl	1056	23	nondiscontinuous	nondiscontinuous	NNP
cord-259603-bh198xgl	1056	24	subgenomic	subgenomic	NNP
cord-259603-bh198xgl	1056	25	RNA	RNA	NNP
cord-259603-bh198xgl	1056	26	transcription	transcription	NN
cord-259603-bh198xgl	1056	27	in	in	IN
cord-259603-bh198xgl	1056	28	a	a	DT
cord-259603-bh198xgl	1056	29	nidovirus	nidovirus	NNP
cord-259603-bh198xgl	1056	30	Crystal	Crystal	NNP
cord-259603-bh198xgl	1056	31	structures	structure	NNS
cord-259603-bh198xgl	1056	32	of	of	IN
cord-259603-bh198xgl	1056	33	complexes	complex	NNS
cord-259603-bh198xgl	1056	34	of	of	IN
cord-259603-bh198xgl	1056	35	PcrA	PcrA	NNP
cord-259603-bh198xgl	1056	36	DNA	DNA	NNP
cord-259603-bh198xgl	1056	37	helicase	helicase	NN
cord-259603-bh198xgl	1056	38	with	with	IN
cord-259603-bh198xgl	1056	39	a	a	DT
cord-259603-bh198xgl	1056	40	DNA	dna	NN
cord-259603-bh198xgl	1056	41	substrate	substrate	NN
cord-259603-bh198xgl	1056	42	indicate	indicate	VBP
cord-259603-bh198xgl	1056	43	an	an	DT
cord-259603-bh198xgl	1056	44	inchworm	inchworm	NN
cord-259603-bh198xgl	1056	45	mechanism	mechanism	NN
cord-259603-bh198xgl	1056	46	New	new	JJ
cord-259603-bh198xgl	1056	47	insights	insight	NNS
cord-259603-bh198xgl	1056	48	on	on	IN
cord-259603-bh198xgl	1056	49	the	the	DT
cord-259603-bh198xgl	1056	50	role	role	NN
cord-259603-bh198xgl	1056	51	of	of	IN
cord-259603-bh198xgl	1056	52	paired	pair	VBN
cord-259603-bh198xgl	1056	53	membrane	membrane	NN
cord-259603-bh198xgl	1056	54	structures	structure	NNS
cord-259603-bh198xgl	1056	55	in	in	IN
cord-259603-bh198xgl	1056	56	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1056	57	replication	replication	NN
cord-259603-bh198xgl	1056	58	Analysis	Analysis	NNP
cord-259603-bh198xgl	1056	59	of	of	IN
cord-259603-bh198xgl	1056	60	intraviral	intraviral	JJ
cord-259603-bh198xgl	1056	61	protein	protein	NN
cord-259603-bh198xgl	1056	62	-	-	HYPH
cord-259603-bh198xgl	1056	63	protein	protein	NN
cord-259603-bh198xgl	1056	64	interactions	interaction	NNS
cord-259603-bh198xgl	1056	65	of	of	IN
cord-259603-bh198xgl	1056	66	the	the	DT
cord-259603-bh198xgl	1056	67	SARS	SARS	NNP
cord-259603-bh198xgl	1056	68	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1056	69	ORFeome	ORFeome	NNP
cord-259603-bh198xgl	1056	70	mRNA	mRNA	NNP
cord-259603-bh198xgl	1057	1	cap-1	cap-1	LS
cord-259603-bh198xgl	1057	2	methyltransferase	methyltransferase	NNP
cord-259603-bh198xgl	1057	3	in	in	IN
cord-259603-bh198xgl	1057	4	the	the	DT
cord-259603-bh198xgl	1057	5	SARS	SARS	NNP
cord-259603-bh198xgl	1057	6	genome	genome	NN
cord-259603-bh198xgl	1057	7	Distantly	distantly	RB
cord-259603-bh198xgl	1057	8	related	related	JJ
cord-259603-bh198xgl	1057	9	sequences	sequence	NNS
cord-259603-bh198xgl	1057	10	in	in	IN
cord-259603-bh198xgl	1057	11	the	the	DT
cord-259603-bh198xgl	1057	12	alpha	alpha	NN
cord-259603-bh198xgl	1057	13	-	-	HYPH
cord-259603-bh198xgl	1057	14	and	and	CC
cord-259603-bh198xgl	1057	15	beta	beta	NN
cord-259603-bh198xgl	1057	16	-	-	HYPH
cord-259603-bh198xgl	1057	17	subunits	subunit	NNS
cord-259603-bh198xgl	1057	18	of	of	IN
cord-259603-bh198xgl	1057	19	ATP	ATP	NNP
cord-259603-bh198xgl	1057	20	synthase	synthase	NN
cord-259603-bh198xgl	1057	21	,	,	,
cord-259603-bh198xgl	1057	22	myosin	myosin	NNS
cord-259603-bh198xgl	1057	23	,	,	,
cord-259603-bh198xgl	1057	24	kinases	kinase	NNS
cord-259603-bh198xgl	1057	25	and	and	CC
cord-259603-bh198xgl	1057	26	other	other	JJ
cord-259603-bh198xgl	1057	27	ATP	ATP	NNP
cord-259603-bh198xgl	1057	28	-	-	HYPH
cord-259603-bh198xgl	1057	29	requiring	require	VBG
cord-259603-bh198xgl	1057	30	enzymes	enzyme	NNS
cord-259603-bh198xgl	1057	31	and	and	CC
cord-259603-bh198xgl	1057	32	a	a	DT
cord-259603-bh198xgl	1057	33	common	common	JJ
cord-259603-bh198xgl	1057	34	nucleotide	nucleotide	NN
cord-259603-bh198xgl	1057	35	binding	bind	VBG
cord-259603-bh198xgl	1057	36	fold	fold	IN
cord-259603-bh198xgl	1057	37	Coronavirus	Coronavirus	NNP
cord-259603-bh198xgl	1057	38	nsp10/	nsp10/	NNS
cord-259603-bh198xgl	1058	1	nsp16	nsp16	NNS
cord-259603-bh198xgl	1059	1	methyltransferase	methyltransferase	NNP
cord-259603-bh198xgl	1059	2	can	can	MD
cord-259603-bh198xgl	1059	3	be	be	VB
cord-259603-bh198xgl	1059	4	targeted	target	VBN
cord-259603-bh198xgl	1059	5	by	by	IN
cord-259603-bh198xgl	1059	6	nsp10-derived	nsp10-derived	JJ
cord-259603-bh198xgl	1059	7	peptide	peptide	NN
cord-259603-bh198xgl	1059	8	in	in	IN
cord-259603-bh198xgl	1059	9	vitro	vitro	FW
cord-259603-bh198xgl	1059	10	and	and	CC
cord-259603-bh198xgl	1059	11	in	in	IN
cord-259603-bh198xgl	1059	12	vivo	vivo	NN
cord-259603-bh198xgl	1059	13	to	to	TO
cord-259603-bh198xgl	1059	14	reduce	reduce	VB
cord-259603-bh198xgl	1059	15	replication	replication	NN
cord-259603-bh198xgl	1059	16	and	and	CC
cord-259603-bh198xgl	1059	17	pathogenesis	pathogenesis	NN
cord-259603-bh198xgl	1059	18	Protection	Protection	NNP
cord-259603-bh198xgl	1059	19	against	against	IN
cord-259603-bh198xgl	1059	20	filovirus	filovirus	NN
cord-259603-bh198xgl	1059	21	diseases	disease	NNS
cord-259603-bh198xgl	1059	22	by	by	IN
cord-259603-bh198xgl	1059	23	a	a	DT
cord-259603-bh198xgl	1059	24	novel	novel	JJ
cord-259603-bh198xgl	1059	25	broad	broad	JJ
cord-259603-bh198xgl	1059	26	-	-	HYPH
cord-259603-bh198xgl	1059	27	spectrum	spectrum	NN
cord-259603-bh198xgl	1059	28	nucleoside	nucleoside	NN
cord-259603-bh198xgl	1059	29	analogue	analogue	NN
cord-259603-bh198xgl	1059	30	BCX4430	BCX4430	NNP
cord-259603-bh198xgl	1060	1	Nonstructural	nonstructural	JJ
cord-259603-bh198xgl	1060	2	proteins	protein	NNS
cord-259603-bh198xgl	1060	3	7	7	CD
cord-259603-bh198xgl	1060	4	and	and	CC
cord-259603-bh198xgl	1060	5	8	8	CD
cord-259603-bh198xgl	1060	6	of	of	IN
cord-259603-bh198xgl	1060	7	feline	feline	JJ
cord-259603-bh198xgl	1060	8	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1060	9	form	form	VB
cord-259603-bh198xgl	1060	10	a	a	DT
cord-259603-bh198xgl	1060	11	2:1	2:1	CD
cord-259603-bh198xgl	1060	12	heterotrimer	heterotrimer	NN
cord-259603-bh198xgl	1060	13	that	that	WDT
cord-259603-bh198xgl	1060	14	exhibits	exhibit	VBZ
cord-259603-bh198xgl	1060	15	primer	primer	NN
cord-259603-bh198xgl	1060	16	-	-	HYPH
cord-259603-bh198xgl	1060	17	independent	independent	JJ
cord-259603-bh198xgl	1060	18	RNA	RNA	NNP
cord-259603-bh198xgl	1060	19	polymerase	polymerase	NN
cord-259603-bh198xgl	1060	20	activity	activity	NN
cord-259603-bh198xgl	1061	1	Expanding	expand	VBG
cord-259603-bh198xgl	1061	2	use	use	NN
cord-259603-bh198xgl	1061	3	of	of	IN
cord-259603-bh198xgl	1061	4	multi	multi	JJ
cord-259603-bh198xgl	1061	5	-	-	JJ
cord-259603-bh198xgl	1061	6	origin	origin	JJ
cord-259603-bh198xgl	1061	7	subcellular	subcellular	JJ
cord-259603-bh198xgl	1061	8	membranes	membrane	NNS
cord-259603-bh198xgl	1061	9	by	by	IN
cord-259603-bh198xgl	1061	10	positivestrand	positivestrand	NNP
cord-259603-bh198xgl	1061	11	RNA	RNA	NNP
cord-259603-bh198xgl	1061	12	viruses	virus	NNS
cord-259603-bh198xgl	1061	13	during	during	IN
cord-259603-bh198xgl	1061	14	replication	replication	NN
cord-259603-bh198xgl	1061	15	Molecular	molecular	JJ
cord-259603-bh198xgl	1061	16	model	model	NN
cord-259603-bh198xgl	1061	17	of	of	IN
cord-259603-bh198xgl	1061	18	SARS	SARS	NNP
cord-259603-bh198xgl	1061	19	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1061	20	polymerase	polymerase	NN
cord-259603-bh198xgl	1061	21	:	:	:
cord-259603-bh198xgl	1061	22	implications	implication	NNS
cord-259603-bh198xgl	1061	23	for	for	IN
cord-259603-bh198xgl	1061	24	biochemical	biochemical	JJ
cord-259603-bh198xgl	1061	25	functions	function	NNS
cord-259603-bh198xgl	1061	26	and	and	CC
cord-259603-bh198xgl	1061	27	drug	drug	NN
cord-259603-bh198xgl	1061	28	design	design	NN
cord-259603-bh198xgl	1061	29	New	new	JJ
cord-259603-bh198xgl	1061	30	antiviral	antiviral	JJ
cord-259603-bh198xgl	1061	31	target	target	NN
cord-259603-bh198xgl	1061	32	revealed	reveal	VBN
cord-259603-bh198xgl	1061	33	by	by	IN
cord-259603-bh198xgl	1061	34	the	the	DT
cord-259603-bh198xgl	1061	35	hexameric	hexameric	JJ
cord-259603-bh198xgl	1061	36	structure	structure	NN
cord-259603-bh198xgl	1061	37	of	of	IN
cord-259603-bh198xgl	1061	38	mouse	mouse	NNP
cord-259603-bh198xgl	1061	39	hepatitis	hepatitis	NNP
cord-259603-bh198xgl	1061	40	virus	virus	NN
cord-259603-bh198xgl	1061	41	nonstructural	nonstructural	JJ
cord-259603-bh198xgl	1061	42	protein	protein	NN
cord-259603-bh198xgl	1061	43	nsp15	nsp15	CD
cord-259603-bh198xgl	1061	44	Coronavirus	Coronavirus	NNP
cord-259603-bh198xgl	1061	45	infection	infection	NN
cord-259603-bh198xgl	1061	46	induces	induce	VBZ
cord-259603-bh198xgl	1061	47	DNA	dna	NN
cord-259603-bh198xgl	1061	48	replication	replication	NN
cord-259603-bh198xgl	1061	49	stress	stress	NN
cord-259603-bh198xgl	1061	50	partly	partly	RB
cord-259603-bh198xgl	1061	51	through	through	IN
cord-259603-bh198xgl	1061	52	interaction	interaction	NN
cord-259603-bh198xgl	1061	53	of	of	IN
cord-259603-bh198xgl	1061	54	its	-PRON-	PRP$
cord-259603-bh198xgl	1061	55	nonstructural	nonstructural	JJ
cord-259603-bh198xgl	1061	56	protein	protein	NN
cord-259603-bh198xgl	1061	57	13	13	CD
cord-259603-bh198xgl	1061	58	with	with	IN
cord-259603-bh198xgl	1061	59	the	the	DT
cord-259603-bh198xgl	1061	60	p125	p125	NNP
cord-259603-bh198xgl	1061	61	subunit	subunit	NN
cord-259603-bh198xgl	1061	62	of	of	IN
cord-259603-bh198xgl	1061	63	DNA	dna	NN
cord-259603-bh198xgl	1061	64	polymerase	polymerase	NN
cord-259603-bh198xgl	1062	1	delta	delta	NNP
cord-259603-bh198xgl	1063	1	The	the	DT
cord-259603-bh198xgl	1063	2	structure	structure	NN
cord-259603-bh198xgl	1063	3	and	and	CC
cord-259603-bh198xgl	1063	4	functions	function	NNS
cord-259603-bh198xgl	1063	5	of	of	IN
cord-259603-bh198xgl	1063	6	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1063	7	genomic	genomic	JJ
cord-259603-bh198xgl	1063	8	3	3	CD
cord-259603-bh198xgl	1063	9	0	0	CD
cord-259603-bh198xgl	1063	10	and	and	CC
cord-259603-bh198xgl	1063	11	5	5	CD
cord-259603-bh198xgl	1063	12	0	0	CD
cord-259603-bh198xgl	1063	13	ends	end	NNS
cord-259603-bh198xgl	1064	1	Inhibition	inhibition	NN
cord-259603-bh198xgl	1064	2	of	of	IN
cord-259603-bh198xgl	1064	3	SARS	SARS	NNP
cord-259603-bh198xgl	1064	4	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1064	5	helicase	helicase	NN
cord-259603-bh198xgl	1064	6	by	by	IN
cord-259603-bh198xgl	1064	7	bismuth	bismuth	NN
cord-259603-bh198xgl	1064	8	complexes	complex	NNS
cord-259603-bh198xgl	1065	1	Enzyme	enzyme	NN
cord-259603-bh198xgl	1065	2	-	-	HYPH
cord-259603-bh198xgl	1065	3	catalyzed	catalyze	VBN
cord-259603-bh198xgl	1065	4	DNA	dna	NN
cord-259603-bh198xgl	1065	5	unwinding	unwinding	NN
cord-259603-bh198xgl	1065	6	:	:	:
cord-259603-bh198xgl	1065	7	studies	study	NNS
cord-259603-bh198xgl	1065	8	on	on	IN
cord-259603-bh198xgl	1065	9	Escherichia	Escherichia	NNP
cord-259603-bh198xgl	1065	10	coli	coli	NNS
cord-259603-bh198xgl	1065	11	rep	rep	NNP
cord-259603-bh198xgl	1065	12	protein	protein	NN
cord-259603-bh198xgl	1065	13	Identification	Identification	NNP
cord-259603-bh198xgl	1065	14	of	of	IN
cord-259603-bh198xgl	1065	15	myricetin	myricetin	NNP
cord-259603-bh198xgl	1065	16	and	and	CC
cord-259603-bh198xgl	1065	17	scutellarein	scutellarein	NNP
cord-259603-bh198xgl	1065	18	as	as	IN
cord-259603-bh198xgl	1065	19	novel	novel	JJ
cord-259603-bh198xgl	1065	20	chemical	chemical	NN
cord-259603-bh198xgl	1065	21	inhibitors	inhibitor	NNS
cord-259603-bh198xgl	1065	22	of	of	IN
cord-259603-bh198xgl	1065	23	the	the	DT
cord-259603-bh198xgl	1065	24	SARS	SARS	NNP
cord-259603-bh198xgl	1065	25	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1065	26	helicase	helicase	NN
cord-259603-bh198xgl	1065	27	,	,	,
cord-259603-bh198xgl	1065	28	nsp13	nsp13	NNP
cord-259603-bh198xgl	1065	29	Identification	identification	NN
cord-259603-bh198xgl	1065	30	and	and	CC
cord-259603-bh198xgl	1065	31	characterization	characterization	NN
cord-259603-bh198xgl	1065	32	of	of	IN
cord-259603-bh198xgl	1065	33	a	a	DT
cord-259603-bh198xgl	1065	34	ribose	ribose	NN
cord-259603-bh198xgl	1065	35	2	2	CD
cord-259603-bh198xgl	1065	36	0	0	CD
cord-259603-bh198xgl	1065	37	-O	-o	CD
cord-259603-bh198xgl	1065	38	-	-	HYPH
cord-259603-bh198xgl	1065	39	methyltransferase	methyltransferase	NN
cord-259603-bh198xgl	1065	40	encoded	encode	VBN
cord-259603-bh198xgl	1065	41	by	by	IN
cord-259603-bh198xgl	1065	42	the	the	DT
cord-259603-bh198xgl	1065	43	ronivirus	ronivirus	NNP
cord-259603-bh198xgl	1065	44	branch	branch	NN
cord-259603-bh198xgl	1065	45	of	of	IN
cord-259603-bh198xgl	1065	46	Nidovirales	Nidovirales	NNP
cord-259603-bh198xgl	1065	47	Insights	Insights	NNP
cord-259603-bh198xgl	1065	48	into	into	IN
cord-259603-bh198xgl	1065	49	SARS	SARS	NNP
cord-259603-bh198xgl	1065	50	-	-	HYPH
cord-259603-bh198xgl	1065	51	CoV	CoV	NNP
cord-259603-bh198xgl	1065	52	transcription	transcription	NN
cord-259603-bh198xgl	1065	53	and	and	CC
cord-259603-bh198xgl	1065	54	replication	replication	NN
cord-259603-bh198xgl	1065	55	from	from	IN
cord-259603-bh198xgl	1065	56	the	the	DT
cord-259603-bh198xgl	1065	57	structure	structure	NN
cord-259603-bh198xgl	1065	58	of	of	IN
cord-259603-bh198xgl	1065	59	the	the	DT
cord-259603-bh198xgl	1065	60	nsp7-nsp8	nsp7-nsp8	NNP
cord-259603-bh198xgl	1065	61	hexadecamer	hexadecamer	NN
cord-259603-bh198xgl	1065	62	Processing	processing	NN
cord-259603-bh198xgl	1065	63	of	of	IN
cord-259603-bh198xgl	1065	64	the	the	DT
cord-259603-bh198xgl	1065	65	human	human	JJ
cord-259603-bh198xgl	1065	66	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1065	67	229E	229e	CD
cord-259603-bh198xgl	1065	68	replicase	replicase	NN
cord-259603-bh198xgl	1065	69	polyproteins	polyprotein	NNS
cord-259603-bh198xgl	1065	70	by	by	IN
cord-259603-bh198xgl	1065	71	the	the	DT
cord-259603-bh198xgl	1065	72	virus	virus	NN
cord-259603-bh198xgl	1065	73	-	-	HYPH
cord-259603-bh198xgl	1065	74	encoded	encode	VBN
cord-259603-bh198xgl	1065	75	3C	3c	NN
cord-259603-bh198xgl	1065	76	-	-	HYPH
cord-259603-bh198xgl	1065	77	like	like	JJ
cord-259603-bh198xgl	1065	78	proteinase	proteinase	NN
cord-259603-bh198xgl	1065	79	:	:	:
cord-259603-bh198xgl	1065	80	identification	identification	NN
cord-259603-bh198xgl	1065	81	of	of	IN
cord-259603-bh198xgl	1065	82	proteolytic	proteolytic	JJ
cord-259603-bh198xgl	1065	83	products	product	NNS
cord-259603-bh198xgl	1065	84	and	and	CC
cord-259603-bh198xgl	1065	85	cleavage	cleavage	NN
cord-259603-bh198xgl	1065	86	sites	site	NNS
cord-259603-bh198xgl	1065	87	common	common	JJ
cord-259603-bh198xgl	1065	88	to	to	IN
cord-259603-bh198xgl	1065	89	pp1a	pp1a	NNP
cord-259603-bh198xgl	1065	90	and	and	CC
cord-259603-bh198xgl	1065	91	pp1ab	pp1ab	NNP
cord-259603-bh198xgl	1065	92	Virus	Virus	NNP
cord-259603-bh198xgl	1065	93	-	-	HYPH
cord-259603-bh198xgl	1065	94	encoded	encode	VBN
cord-259603-bh198xgl	1065	95	proteinases	proteinase	NNS
cord-259603-bh198xgl	1065	96	and	and	CC
cord-259603-bh198xgl	1065	97	proteolytic	proteolytic	JJ
cord-259603-bh198xgl	1065	98	processing	processing	NN
cord-259603-bh198xgl	1065	99	in	in	IN
cord-259603-bh198xgl	1065	100	the	the	DT
cord-259603-bh198xgl	1065	101	Nidovirales	Nidovirales	NNP
cord-259603-bh198xgl	1066	1	An	an	DT
cord-259603-bh198xgl	1066	2	insect	insect	NN
cord-259603-bh198xgl	1066	3	nidovirus	nidovirus	NN
cord-259603-bh198xgl	1066	4	emerging	emerge	VBG
cord-259603-bh198xgl	1066	5	from	from	IN
cord-259603-bh198xgl	1066	6	a	a	DT
cord-259603-bh198xgl	1066	7	primary	primary	JJ
cord-259603-bh198xgl	1066	8	tropical	tropical	JJ
cord-259603-bh198xgl	1066	9	rainforest	rainforest	NN
cord-259603-bh198xgl	1066	10	Identification	identification	NN
cord-259603-bh198xgl	1066	11	and	and	CC
cord-259603-bh198xgl	1066	12	characterization	characterization	NN
cord-259603-bh198xgl	1066	13	of	of	IN
cord-259603-bh198xgl	1066	14	genetically	genetically	RB
cord-259603-bh198xgl	1066	15	divergent	divergent	JJ
cord-259603-bh198xgl	1066	16	members	member	NNS
cord-259603-bh198xgl	1066	17	of	of	IN
cord-259603-bh198xgl	1066	18	the	the	DT
cord-259603-bh198xgl	1066	19	newly	newly	RB
cord-259603-bh198xgl	1066	20	established	establish	VBN
cord-259603-bh198xgl	1066	21	family	family	NN
cord-259603-bh198xgl	1066	22	Mesoniviridae	Mesoniviridae	NNP
cord-259603-bh198xgl	1066	23	Coronaviruses	Coronaviruses	NNP
cord-259603-bh198xgl	1066	24	-	-	HYPH
cord-259603-bh198xgl	1066	25	drug	drug	NN
cord-259603-bh198xgl	1066	26	discovery	discovery	NN
cord-259603-bh198xgl	1066	27	and	and	CC
cord-259603-bh198xgl	1066	28	therapeutic	therapeutic	JJ
cord-259603-bh198xgl	1066	29	options	option	NNS
cord-259603-bh198xgl	1066	30	Exoribonuclease	Exoribonuclease	NNP
cord-259603-bh198xgl	1066	31	superfamilies	superfamily	NNS
cord-259603-bh198xgl	1066	32	:	:	:
cord-259603-bh198xgl	1066	33	structural	structural	JJ
cord-259603-bh198xgl	1066	34	analysis	analysis	NN
cord-259603-bh198xgl	1066	35	and	and	CC
cord-259603-bh198xgl	1066	36	phylogenetic	phylogenetic	NN
cord-259603-bh198xgl	1066	37	distribution	distribution	NN
cord-259603-bh198xgl	1067	1	Genetic	genetic	JJ
cord-259603-bh198xgl	1067	2	interactions	interaction	NNS
cord-259603-bh198xgl	1067	3	between	between	IN
cord-259603-bh198xgl	1067	4	an	an	DT
cord-259603-bh198xgl	1067	5	essential	essential	JJ
cord-259603-bh198xgl	1067	6	3	3	CD
cord-259603-bh198xgl	1067	7	0	0	CD
cord-259603-bh198xgl	1067	8	cis	cis	NNP
cord-259603-bh198xgl	1067	9	-	-	HYPH
cord-259603-bh198xgl	1067	10	acting	act	VBG
cord-259603-bh198xgl	1067	11	RNA	RNA	NNP
cord-259603-bh198xgl	1067	12	pseudoknot	pseudoknot	NNP
cord-259603-bh198xgl	1067	13	,	,	,
cord-259603-bh198xgl	1067	14	replicase	replicase	NNP
cord-259603-bh198xgl	1067	15	gene	gene	NN
cord-259603-bh198xgl	1067	16	products	product	NNS
cord-259603-bh198xgl	1067	17	,	,	,
cord-259603-bh198xgl	1067	18	and	and	CC
cord-259603-bh198xgl	1067	19	the	the	DT
cord-259603-bh198xgl	1067	20	extreme	extreme	JJ
cord-259603-bh198xgl	1067	21	3	3	CD
cord-259603-bh198xgl	1067	22	0	0	CD
cord-259603-bh198xgl	1067	23	end	end	NN
cord-259603-bh198xgl	1067	24	of	of	IN
cord-259603-bh198xgl	1067	25	the	the	DT
cord-259603-bh198xgl	1067	26	mouse	mouse	NN
cord-259603-bh198xgl	1067	27	coronavirus	coronavirus	NN
cord-259603-bh198xgl	1067	28	genome	genome	NN
cord-259603-bh198xgl	1067	29	Ribose	Ribose	NNP
cord-259603-bh198xgl	1067	30	2	2	CD
cord-259603-bh198xgl	1067	31	0	0	CD
cord-259603-bh198xgl	1067	32	-O	-o	CD
cord-259603-bh198xgl	1067	33	-	-	HYPH
cord-259603-bh198xgl	1067	34	methylation	methylation	NN
cord-259603-bh198xgl	1067	35	provides	provide	VBZ
cord-259603-bh198xgl	1067	36	a	a	DT
cord-259603-bh198xgl	1067	37	molecular	molecular	JJ
cord-259603-bh198xgl	1067	38	signature	signature	NN
cord-259603-bh198xgl	1067	39	for	for	IN
cord-259603-bh198xgl	1067	40	the	the	DT
cord-259603-bh198xgl	1067	41	distinction	distinction	NN
cord-259603-bh198xgl	1067	42	of	of	IN
cord-259603-bh198xgl	1067	43	self	self	NN
cord-259603-bh198xgl	1067	44	and	and	CC
cord-259603-bh198xgl	1067	45	non	non	JJ
cord-259603-bh198xgl	1067	46	-	-	JJ
cord-259603-bh198xgl	1067	47	self	self	JJ
cord-259603-bh198xgl	1067	48	mRNA	mrna	NN
cord-259603-bh198xgl	1067	49	dependent	dependent	JJ
cord-259603-bh198xgl	1067	50	on	on	IN
cord-259603-bh198xgl	1067	51	the	the	DT
cord-259603-bh198xgl	1067	52	RNA	RNA	NNP
cord-259603-bh198xgl	1067	53	sensor	sensor	NN
cord-259603-bh198xgl	1067	54	Mda5	Mda5	NNP