id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-350451-lf27iuwk	Benedetti, Francesca	SARS‐CoV‐2: March toward adaptation	2020-07-11		.txt	text/plain	1212	79	44	A third factor still subject of debate is how and how much the mutations observed in SARS-CoV-2 provide an indication of viral fitness and adaptation, and their role first into the initial phases of transmission and now during the reduction of viral spreading. The worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel human pathogen, first detected in China quickly became a global health emergency, culminating with the World Health Organization publicly proclaiming the SARS-CoV-2 outbreak as a pandemic (11 March 2020) . Several reports result show that SARS-CoV-2 is rapidly moving across countries, and new mutation hotspots are emerging in different parts of the genome. Although SARS-CoV-2 is less lethal than MERS-CoV, up to 20% of the infected people develop rapidly a severe disease characterized by interstitial pneumonia and acute respiratory distress syndrome that can ultimately lead to death. Davide Zella http://orcid.org/0000-0001-5576-5770 Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant	./cache/cord-350451-lf27iuwk.txt	./txt/cord-350451-lf27iuwk.txt