id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-350015-mg5wiihj	Chen, Yiyin	Aging in COVID-19: Vulnerability, immunity and intervention	2020-10-31		.txt	text/plain	7489	407	47	The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic was first reported in Wuhan, China in December 2019, moved across the globe at an unprecedented speed, and has caused a profound and yet still unfolding health and socioeconomic impacts. We hypothesize that age-related decline and dysregulation of immune function, i.e., immunosenescence and inflammaging play a major role in contributing to heightened vulnerability to severe COVID-19 outcomes in older adults. Therefore, age-associated reduction in type 1 IFN response coupled with direct viral suppression could serve as a critical innate immune mechanism that leads to poor cell mediated immunity and increased vulnerability of older adults against SARS-CoV-2 infection with therapeutic implication (Sallard et al., 2020) . On the other hand, children with COVID-19 manifested lower levels of T cell activation than adult COVID-19 patients (Moratto et al., 2020) , suggesting better immune system control and regulation in response to SARS-CoV-2 infection in children.	./cache/cord-350015-mg5wiihj.txt	./txt/cord-350015-mg5wiihj.txt