id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-343528-5283jsnu	Zhang, Zhao	Evolutionary Dynamics of MERS-CoV: Potential Recombination, Positive Selection and Transmission	2016-05-04		.txt	text/plain	4745	251	55	Our analyses show: 1) 28 potential recombinant sequences were detected and they can be classified into seven potential recombinant types; 2) The spike (S) protein of MERS-CoV was under strong positive selection when MERS-CoV transmitted from their natural host to human; 3) Six out of nine positive selection sites detected in spike (S) protein are located in its receptor-binding domain which is in direct contact with host cells; 4) MERS-CoV frequently transmitted back and forth between human and camel after it had acquired the human-camel infection capability. Together, these results suggest that potential recombination events might have happened frequently during MERS-CoV's evolutionary history and the positive selection sites in MERS-CoV's S protein might enable it to infect human. In order to study the temporal and spatial pattern of MERS-CoV transmission, a maximum clade credibility (MCC) tree was constructed using MERS-CoV whole genome sequences without recombinant strains (Fig. 3c) . The amino acid sites under positive selection in MERS-CoV S protein, especially those in its receptor binding domain, might have facilitated its cross-species transmission from animal host to human. All authors reviewed the manuscript.	./cache/cord-343528-5283jsnu.txt	./txt/cord-343528-5283jsnu.txt