id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-340049-6rqmc89u	Salvatori, Giovanni	SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines	2020-06-03		.txt	text/plain	1411	86	44	Evidence of the key role played by the S protein in counteracting coronavirus infection came from studies on human-neutralizing antibodies from rare memory B cells of individuals infected with SARS-CoV [2] or MERS-CoV [3] . Journal of Translational Medicine antibody responses, and vigorously neutralized SARS-CoV-2 S-mediated entry into cells, thus further encouraging the use of this molecular target for vaccination and immunotherapies [4] . Given the above and that the coronavirus S glycoprotein is surface-exposed and mediates entry into host cells by interacting with angiotensin-converting enzyme 2 (ACE2), it rapidly became the main target of neutralizing antibodies and the focus of therapeutic and vaccine design. Several companies and research institutes have started developing a vaccine that has the SARS-CoV-2 protein S as its target (see Table 1 ), although the various vaccination strategies show a differing ability to induce in the host both an antibody-mediated humoral response and a cell response mediated by CD4 or CD8 T lymphocytes in preclinical models.	./cache/cord-340049-6rqmc89u.txt	./txt/cord-340049-6rqmc89u.txt