id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-334976-53cd16w5	Jo, Seri	Flavonoids with inhibitory activity against SARS-CoV-2 3CLpro	2020-08-04		.txt	text/plain	3659	222	55	An in silico docking study showed that the binding modes of herbacetin and pectolinarin are similar to those obtained from the catalytic domain of SARS-CoV 3CLpro. Baicalin showed an effective inhibitory activity against SARS-CoV-2 3CLpro and its docking mode is different from those of herbacetin and pectolinarin. The proteolytic assay using SARS-CoV-2 3CLpro in the presence of Triton X-100 has been performed to differentiate the artificial inhibitory activity of chemicals through non-specific binding with proteases by forming aggregate or complexation. The compound showed the severely reduced fluorescent intensity and thus represented their SARS-CoV-2 3CLpro inhibitory activity. Among them, baicalin, herbacetin and pectolinarin revealed the prominent inhibitory activity against SARS-CoV-2 3CLpro. The binding modes of herbacetin and pectolinarin were similar to those obtained from the docking study of the catalytic domain of SARS-CoV 3CLpro 21 . In the previous results of SARS-CoV 3CLpro 21 , only the three effect flavonoids (herbacetin, pectolinarin, and rhoifolin) were mentioned.	./cache/cord-334976-53cd16w5.txt	./txt/cord-334976-53cd16w5.txt