id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-322051-89wgv100	Tanasa, Ingrid Andrada	Anosmia and ageusia associated with coronavirus infection (COVID-19) - what is known?	2020-05-28		.txt	text/plain	2260	132	44	This study summarizes the existing data regarding the association of anosmia and ageusia with the SARS-CoV-2 infection. In a retrospective observational study, Klopfenstein et al (20) reported that 54 patients (47%) with confirmed SARS-CoV-2 infection developed anosmia, 4.4 (±1.9) days after infection onset, and that was the third symptom to manifest in 38% (22/52) of the cases. Some authors reported three mechanisms for anosmia in COVID-19 patients: i) local infection of support cells and vascular pericytes in the nose and olfactory bulb that may affect the function of bipolar neurons or mitral cells; ii) damage to support cells in the sensory epithelium that may indirectly influence the signaling pathway from sensory neurons to the brain; and iii) damage to sustentacular cells and Bowman's gland cells that could lead to diffuse morphological damage to the olfactory sensory epithelium and altering of smell perception (28, 29) . Further research is needed to demonstrate the association between anosmia and ageusia with SARS-CoV-2 infection, the clinical manifestations determined by variants of ACE2 receptor, and recovery rates of olfactory and gustative dysfunction, and specific treatment protocols of these manifestations.	./cache/cord-322051-89wgv100.txt	./txt/cord-322051-89wgv100.txt