id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-311125-v9ddes3c	Cooper, Keiland W.	COVID-19 and the chemical senses: supporting players take center stage	2020-07-01		.txt	text/plain	9480	510	49	Given data suggesting that ACE2 is necessary for SARS-CoV2 to infect host cells, researchers have used a variety of approaches to discern the pattern of expression of ACE2 and other viral entry proteins across the tissue landscape, with the goal of inferring possible target cells and disease mechanisms. It remains unclear whether SARS-CoV-2 (given that it likely does not directly infect OSNs, and thus cannot pass directly through the olfactory nerve, see However, scSeq and immunostaining of the mouse OB has revealed -as in the nose -that bulb neurons do not express detectable levels of ACE2 ( Figure 2 ) . This model suggests that neural function is altered indirectly due to sequelae of SARS-CoV-2 infection of peripheral support cells, including (but not limited to) local inflammation and changes in OSN gene expression and ciliary structure. Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia	./cache/cord-311125-v9ddes3c.txt	./txt/cord-311125-v9ddes3c.txt