id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304073-f3iwclkm	Mullick, Jhinuk Basu	Animal Models to Study Emerging Technologies Against SARS-CoV-2	2020-07-27		.txt	text/plain	5315	322	50	Animal models are indispensable to understand these processes and develop and test emerging technologies; however, the mechanism of infection for SARS-CoV-2 requires certain similarities to humans that do not exist in common laboratory rodents. Here, we review important elements of viral infection, transmission, and clinical presentation reflected by various animal models readily available or being developed and studied for SARS-CoV-2 to help bioengineers evaluate appropriate preclinical models for their emerging technologies. Non-human primates, Syrian hamsters, ferrets, cats, and engineered chimeras mimic the human infection more closely and hold strong potential as animal models of SARS-CoV-2 infection and progression of resulting human disease. Overall, the studies show that the Syrian hamster is a useful animal model for SARS-CoV-2 infection especially to study viral replication, shedding, and transmission through the respiratory tract. In all studies, animals developed NAbs. Overall, the rhesus macaque model has been similar in many aspects to the human COVID-19 pathogenesis.	./cache/cord-304073-f3iwclkm.txt	./txt/cord-304073-f3iwclkm.txt