id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302707-cap2rgf7	Ng, Dianna L.	SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood	2020-09-17		.txt	text/plain	4364	224	50	Here, we present data validating the use of the EUA authorized Abbott Architect SARS-CoV-2 IgG test for antibody detection in two populations in March 2020, a hospitalized COVID-19 patient cohort at a tertiary care hospital in San Francisco and a cohort of blood donors from the San Francisco Bay Area. These studies demonstrate that SARS-CoV-2 seroprevalence in the San Francisco Bay Area was very low, suggesting limited circulation of the virus in the community as of early March, and that IgG and IgM titers are predictive of neutralizing activity, with high positive percent agreement. To evaluate assay sensitivity, we assembled a cohort of 38 hospitalized patients and 5 outpatients at University of California, San Francisco (UCSF) Medical Center and the San Francisco Veterans Affairs (SFVA) Health Care System, all of whom received care at adult inpatient units or clinics and were real-time polymerase chain reaction (RT-PCR) positive for SARS-CoV-2 from nasopharyngeal and/or oropharyngeal swab testing ( Fig. 1a and Supplementary Table 1 ).	./cache/cord-302707-cap2rgf7.txt	./txt/cord-302707-cap2rgf7.txt