id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-298669-g2up0cfi	Pollock, David D	Viral CpG deficiency provides no evidence that dogs were intermediate hosts for SARS-CoV-2	2020-07-13		.txt	text/plain	3261	158	52	Nevertheless, the evolutionary reasons for low GC content are still debated in even exceptionally well-studied systems with unquestioned animal origins (2020) points out, the mammalian zinc finger antiviral protein (ZAP) binds to CpG dinucleotides in viral RNA genomes and inhibits viral replication and mediates viral degradation (Ficarelli et al., 2020; Ficarelli et al., 2019; Meagher et al., 2019; Takata et al., 2017) . Despite this, Xia (2020) speculated that low viral genomic CpG levels in SARS-CoV-2 required evolutionary time in a previous host species and tissue that more actively selected for CpG depletion than do bats. In addition to being unsupported by positive evidence, Xia's (2020) hypothesis for dogs as intermediate hosts of ancestral viruses giving rise to SARS-CoV-2 requires an unlikely history of cross-species viral transmission (see Fig. 2 for potential hypotheses) for which there is no evidence.	./cache/cord-298669-g2up0cfi.txt	./txt/cord-298669-g2up0cfi.txt