id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-280068-rszu1c48	Twomey, Julianne D.	COVID-19 update: The race to therapeutic development	2020-10-24		.txt	text/plain	6195	331	42	We highlight two major lines of therapeutic strategies for COVID-19 treatment: 1) repurposing the existing drugs for use in COVID-19 patients, such as antiviral medications (e.g., remdesivir) and immunomodulators (e.g., dexamethasone) which were previously approved for other disease conditions, and 2) novel biological products that are designed to target specific molecules that are involved in SARS-COV-2 viral entry, including neutralizing antibodies against the spike protein of SARS-COV-2, such as REGN-COV2 (an antibody cocktail) and LY-COV555, as well as recombinant human soluble ACE2 protein to counteract SARS-COV-2 binding to the transmembrane ACE2 receptor in target cells. The current review highlights the potential therapeutic strategies for the treatment of COVID-19, including small molecule drugs and therapeutic proteins to target the SARS-CoV-2 viral entry, viral amplification or the host immune responses.	./cache/cord-280068-rszu1c48.txt	./txt/cord-280068-rszu1c48.txt