id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-275138-033r259v	Hayden, Frederick G	Towards improving clinical management of Middle East respiratory syndrome coronavirus infection	2014-07-31		.txt	text/plain	1624	78	38	Many agents have inhibitory activity in vitro for coronaviruses, including some licensed drugs, 7-9 but it is unclear whether their human pharmacology and tolerability would enable suffi cient doses to be given to exert antiviral eff ects in patients with MERS-CoV. 4 Ribavirin and interferon combinations are associated with modest Centre For Infections/Public Health England/Science Photo Library antiviral eff ects in MERS-CoV inoculated rhesus macaques given high doses. 7 For MERS-CoV, low neutralising antibody responses and inability to acquire suffi cient convalescent plasma from survivors with comorbidities might restrict the eff ectiveness of this treatment, although these limitations might not apply to infected health-care workers. With support as needed from international partners like WHO and ISARIC, 11 regional governments, and funders, Middle Eastern colleagues have both the opportunity and the responsibility to undertake studies to advance the understanding of eff ective prevention and treatment strategies for MERS-CoV and any future novel CoV outbreaks.	./cache/cord-275138-033r259v.txt	./txt/cord-275138-033r259v.txt