id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-272113-j82z4q8x	Akaji, Kenichi	Design and Evaluation of Anti-SARS-Coronavirus Agents Based on Molecular Interactions with the Viral Protease	2020-08-27		.txt	text/plain	6459	281	45	Instead of an exhaustive survey of the inhibitors [21] , we provide an overview of several typical inhibitors, and our recent efforts for the rational design of new scaffolds are discussed based on the inhibitory mechanism and structural interactions with SARS-CoV 3CL pro . Following the interaction with the active center of the SARS-CoV 3CL pro , the nucleophilic Cys145 thiolate generated by a proton-withdrawing effect caused by His41 at the catalytic dyad promotes a typical 1,4-addition to the α,β-unsaturated structure of the Michael acceptor ( Figure 3 ). These data also indicate that the corresponding S1 pocket of the SARS-CoV 3CL pro might accept a simple ring structure containing heteroatoms at this specific interaction site, which provides a clue to our design of a potent substrate-based inhibitor described later in this review.	./cache/cord-272113-j82z4q8x.txt	./txt/cord-272113-j82z4q8x.txt