id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-253844-y6xdcf20	Yesudhas, Dhanusha	COVID-19 outbreak: history, mechanism, transmission, structural studies and therapeutics	2020-09-04		.txt	text/plain	7165	422	51	In SARS-CoV-2 infection, intrinsically disordered regions are observed at the interface of the spike protein and ACE2 receptor, providing a shape complementarity to the complex. SUMMARY: The overall history and mechanism of entry of SARS-CoV-2 along with structural study of spike-ACE2 complex provide insights to understand disease pathogenesis and development of vaccines and drugs. The sequence similarity between SARS-CoV-2 and SARS-CoV spike proteins explains the possibility of binding to the same receptor angiotensin converting enzyme 2 (ACE2) in the host cell [14] . In this review, we discuss the history of coronaviruses in both humans and animals, their transmissions, mechanism of host cell entry and the structural studies, explaining active and inactive receptor binding of spike protein and the key residues playing an important role in the receptor binding. During viral infection, spike protein (~ 1300 amino acid residues) is cleaved by host proteases into receptor binding subunit S1 and membrane fusion subunit S2.	./cache/cord-253844-y6xdcf20.txt	./txt/cord-253844-y6xdcf20.txt