id	sid	tid	token	lemma	pos
cord-355758-tk7eturq	1	1	key	key	JJ
cord-355758-tk7eturq	1	2	:	:	:
cord-355758-tk7eturq	1	3	cord-355758-tk7eturq	cord-355758-tk7eturq	CD
cord-355758-tk7eturq	1	4	authors	author	NNS
cord-355758-tk7eturq	1	5	:	:	:
cord-355758-tk7eturq	1	6	Berrio	Berrio	NNP
cord-355758-tk7eturq	1	7	,	,	,
cord-355758-tk7eturq	1	8	Alejandro	Alejandro	NNP
cord-355758-tk7eturq	1	9	;	;	:
cord-355758-tk7eturq	1	10	Gartner	Gartner	NNP
cord-355758-tk7eturq	1	11	,	,	,
cord-355758-tk7eturq	1	12	Valerie	Valerie	NNP
cord-355758-tk7eturq	1	13	;	;	:
cord-355758-tk7eturq	1	14	Wray	Wray	NNP
cord-355758-tk7eturq	1	15	,	,	,
cord-355758-tk7eturq	1	16	Gregory	Gregory	NNP
cord-355758-tk7eturq	1	17	A	a	DT
cord-355758-tk7eturq	1	18	title	title	NN
cord-355758-tk7eturq	1	19	:	:	:
cord-355758-tk7eturq	1	20	Positive	positive	JJ
cord-355758-tk7eturq	1	21	selection	selection	NN
cord-355758-tk7eturq	1	22	within	within	IN
cord-355758-tk7eturq	1	23	the	the	DT
cord-355758-tk7eturq	1	24	genomes	genome	NNS
cord-355758-tk7eturq	1	25	of	of	IN
cord-355758-tk7eturq	1	26	SARS	SARS	NNP
cord-355758-tk7eturq	1	27	-	-	HYPH
cord-355758-tk7eturq	1	28	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	1	29	and	and	CC
cord-355758-tk7eturq	1	30	other	other	JJ
cord-355758-tk7eturq	1	31	Coronaviruses	Coronaviruses	NNP
cord-355758-tk7eturq	1	32	independent	independent	JJ
cord-355758-tk7eturq	1	33	of	of	IN
cord-355758-tk7eturq	1	34	impact	impact	NN
cord-355758-tk7eturq	1	35	on	on	IN
cord-355758-tk7eturq	1	36	protein	protein	NN
cord-355758-tk7eturq	1	37	function	function	NN
cord-355758-tk7eturq	1	38	date	date	NN
cord-355758-tk7eturq	1	39	:	:	:
cord-355758-tk7eturq	1	40	2020	2020	CD
cord-355758-tk7eturq	1	41	-	-	HYPH
cord-355758-tk7eturq	1	42	09	09	CD
cord-355758-tk7eturq	1	43	-	-	SYM
cord-355758-tk7eturq	1	44	22	22	CD
cord-355758-tk7eturq	1	45	journal	journal	NN
cord-355758-tk7eturq	1	46	:	:	:
cord-355758-tk7eturq	2	1	bioRxiv	biorxiv	IN
cord-355758-tk7eturq	2	2	DOI	DOI	NNP
cord-355758-tk7eturq	2	3	:	:	:
cord-355758-tk7eturq	3	1	10.1101/2020.09.16.300038	10.1101/2020.09.16.300038	DT
cord-355758-tk7eturq	3	2	sha	sha	NNP
cord-355758-tk7eturq	3	3	:	:	:
cord-355758-tk7eturq	4	1	0d5bc40fcc656609cce33263dc552fda68d5120b	0d5bc40fcc656609cce33263dc552fda68d5120b	CD
cord-355758-tk7eturq	5	1	doc_id	doc_id	CD
cord-355758-tk7eturq	5	2	:	:	:
cord-355758-tk7eturq	6	1	355758	355758	CD
cord-355758-tk7eturq	6	2	cord_uid	cord_uid	NNS
cord-355758-tk7eturq	6	3	:	:	:
cord-355758-tk7eturq	6	4	tk7eturq	tk7eturq	.
cord-355758-tk7eturq	7	1	Background	background	NN
cord-355758-tk7eturq	8	1	The	the	DT
cord-355758-tk7eturq	8	2	emergence	emergence	NN
cord-355758-tk7eturq	8	3	of	of	IN
cord-355758-tk7eturq	8	4	a	a	DT
cord-355758-tk7eturq	8	5	novel	novel	JJ
cord-355758-tk7eturq	8	6	coronavirus	coronavirus	NN
cord-355758-tk7eturq	8	7	(	(	-LRB-
cord-355758-tk7eturq	8	8	SARS	SARS	NNP
cord-355758-tk7eturq	8	9	-	-	HYPH
cord-355758-tk7eturq	8	10	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	8	11	)	)	-RRB-
cord-355758-tk7eturq	8	12	associated	associate	VBN
cord-355758-tk7eturq	8	13	with	with	IN
cord-355758-tk7eturq	8	14	severe	severe	JJ
cord-355758-tk7eturq	8	15	acute	acute	JJ
cord-355758-tk7eturq	8	16	respiratory	respiratory	JJ
cord-355758-tk7eturq	8	17	disease	disease	NN
cord-355758-tk7eturq	8	18	(	(	-LRB-
cord-355758-tk7eturq	8	19	COVID-19	COVID-19	NNP
cord-355758-tk7eturq	8	20	)	)	-RRB-
cord-355758-tk7eturq	8	21	has	have	VBZ
cord-355758-tk7eturq	8	22	prompted	prompt	VBN
cord-355758-tk7eturq	8	23	efforts	effort	NNS
cord-355758-tk7eturq	8	24	to	to	TO
cord-355758-tk7eturq	8	25	understand	understand	VB
cord-355758-tk7eturq	8	26	the	the	DT
cord-355758-tk7eturq	8	27	genetic	genetic	JJ
cord-355758-tk7eturq	8	28	basis	basis	NN
cord-355758-tk7eturq	8	29	for	for	IN
cord-355758-tk7eturq	8	30	its	-PRON-	PRP$
cord-355758-tk7eturq	8	31	unique	unique	JJ
cord-355758-tk7eturq	8	32	characteristics	characteristic	NNS
cord-355758-tk7eturq	8	33	and	and	CC
cord-355758-tk7eturq	8	34	its	-PRON-	PRP$
cord-355758-tk7eturq	8	35	jump	jump	NN
cord-355758-tk7eturq	8	36	from	from	IN
cord-355758-tk7eturq	8	37	non	non	JJ
cord-355758-tk7eturq	8	38	-	-	JJ
cord-355758-tk7eturq	8	39	primate	primate	JJ
cord-355758-tk7eturq	8	40	hosts	host	NNS
cord-355758-tk7eturq	8	41	to	to	IN
cord-355758-tk7eturq	8	42	humans	human	NNS
cord-355758-tk7eturq	8	43	.	.	.
cord-355758-tk7eturq	9	1	Tests	test	NNS
cord-355758-tk7eturq	9	2	for	for	IN
cord-355758-tk7eturq	9	3	positive	positive	JJ
cord-355758-tk7eturq	9	4	selection	selection	NN
cord-355758-tk7eturq	9	5	can	can	MD
cord-355758-tk7eturq	9	6	identify	identify	VB
cord-355758-tk7eturq	9	7	apparently	apparently	RB
cord-355758-tk7eturq	9	8	nonrandom	nonrandom	JJ
cord-355758-tk7eturq	9	9	patterns	pattern	NNS
cord-355758-tk7eturq	9	10	of	of	IN
cord-355758-tk7eturq	9	11	mutation	mutation	NN
cord-355758-tk7eturq	9	12	accumulation	accumulation	NN
cord-355758-tk7eturq	9	13	within	within	IN
cord-355758-tk7eturq	9	14	genomes	genome	NNS
cord-355758-tk7eturq	9	15	,	,	,
cord-355758-tk7eturq	9	16	highlighting	highlight	VBG
cord-355758-tk7eturq	9	17	regions	region	NNS
cord-355758-tk7eturq	9	18	where	where	WRB
cord-355758-tk7eturq	9	19	molecular	molecular	JJ
cord-355758-tk7eturq	9	20	function	function	NN
cord-355758-tk7eturq	9	21	may	may	MD
cord-355758-tk7eturq	9	22	have	have	VB
cord-355758-tk7eturq	9	23	changed	change	VBN
cord-355758-tk7eturq	9	24	during	during	IN
cord-355758-tk7eturq	9	25	the	the	DT
cord-355758-tk7eturq	9	26	origin	origin	NN
cord-355758-tk7eturq	9	27	of	of	IN
cord-355758-tk7eturq	9	28	a	a	DT
cord-355758-tk7eturq	9	29	species	specie	NNS
cord-355758-tk7eturq	9	30	.	.	.
cord-355758-tk7eturq	10	1	Several	several	JJ
cord-355758-tk7eturq	10	2	recent	recent	JJ
cord-355758-tk7eturq	10	3	studies	study	NNS
cord-355758-tk7eturq	10	4	of	of	IN
cord-355758-tk7eturq	10	5	the	the	DT
cord-355758-tk7eturq	10	6	SARS	SARS	NNP
cord-355758-tk7eturq	10	7	-	-	HYPH
cord-355758-tk7eturq	10	8	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	10	9	genome	genome	NN
cord-355758-tk7eturq	10	10	have	have	VBP
cord-355758-tk7eturq	10	11	identified	identify	VBN
cord-355758-tk7eturq	10	12	signals	signal	NNS
cord-355758-tk7eturq	10	13	of	of	IN
cord-355758-tk7eturq	10	14	conservation	conservation	NN
cord-355758-tk7eturq	10	15	and	and	CC
cord-355758-tk7eturq	10	16	positive	positive	JJ
cord-355758-tk7eturq	10	17	selection	selection	NN
cord-355758-tk7eturq	10	18	within	within	IN
cord-355758-tk7eturq	10	19	the	the	DT
cord-355758-tk7eturq	10	20	gene	gene	NN
cord-355758-tk7eturq	10	21	encoding	encode	VBG
cord-355758-tk7eturq	10	22	Spike	Spike	NNP
cord-355758-tk7eturq	10	23	protein	protein	NN
cord-355758-tk7eturq	10	24	based	base	VBN
cord-355758-tk7eturq	10	25	on	on	IN
cord-355758-tk7eturq	10	26	the	the	DT
cord-355758-tk7eturq	10	27	ratio	ratio	NN
cord-355758-tk7eturq	10	28	of	of	IN
cord-355758-tk7eturq	10	29	synonymous	synonymous	JJ
cord-355758-tk7eturq	10	30	to	to	IN
cord-355758-tk7eturq	10	31	nonsynonymous	nonsynonymous	JJ
cord-355758-tk7eturq	10	32	substitution	substitution	NN
cord-355758-tk7eturq	10	33	.	.	.
cord-355758-tk7eturq	11	1	Such	such	JJ
cord-355758-tk7eturq	11	2	tests	test	NNS
cord-355758-tk7eturq	11	3	can	can	MD
cord-355758-tk7eturq	11	4	not	not	RB
cord-355758-tk7eturq	11	5	,	,	,
cord-355758-tk7eturq	11	6	however	however	RB
cord-355758-tk7eturq	11	7	,	,	,
cord-355758-tk7eturq	11	8	detect	detect	VB
cord-355758-tk7eturq	11	9	changes	change	NNS
cord-355758-tk7eturq	11	10	in	in	IN
cord-355758-tk7eturq	11	11	the	the	DT
cord-355758-tk7eturq	11	12	function	function	NN
cord-355758-tk7eturq	11	13	of	of	IN
cord-355758-tk7eturq	11	14	RNA	RNA	NNP
cord-355758-tk7eturq	11	15	molecules	molecule	NNS
cord-355758-tk7eturq	11	16	.	.	.
cord-355758-tk7eturq	12	1	Methods	method	NNS
cord-355758-tk7eturq	13	1	Here	here	RB
cord-355758-tk7eturq	13	2	we	-PRON-	PRP
cord-355758-tk7eturq	13	3	apply	apply	VBP
cord-355758-tk7eturq	13	4	a	a	DT
cord-355758-tk7eturq	13	5	test	test	NN
cord-355758-tk7eturq	13	6	for	for	IN
cord-355758-tk7eturq	13	7	branch	branch	NN
cord-355758-tk7eturq	13	8	-	-	HYPH
cord-355758-tk7eturq	13	9	specific	specific	JJ
cord-355758-tk7eturq	13	10	oversubstitution	oversubstitution	NN
cord-355758-tk7eturq	13	11	of	of	IN
cord-355758-tk7eturq	13	12	mutations	mutation	NNS
cord-355758-tk7eturq	13	13	within	within	IN
cord-355758-tk7eturq	13	14	narrow	narrow	JJ
cord-355758-tk7eturq	13	15	windows	window	NNS
cord-355758-tk7eturq	13	16	of	of	IN
cord-355758-tk7eturq	13	17	the	the	DT
cord-355758-tk7eturq	13	18	genome	genome	NN
cord-355758-tk7eturq	13	19	without	without	IN
cord-355758-tk7eturq	13	20	reference	reference	NN
cord-355758-tk7eturq	13	21	to	to	IN
cord-355758-tk7eturq	13	22	the	the	DT
cord-355758-tk7eturq	13	23	genetic	genetic	JJ
cord-355758-tk7eturq	13	24	code	code	NN
cord-355758-tk7eturq	13	25	.	.	.
cord-355758-tk7eturq	14	1	Results	result	NNS
cord-355758-tk7eturq	15	1	We	-PRON-	PRP
cord-355758-tk7eturq	15	2	recapitulate	recapitulate	VBP
cord-355758-tk7eturq	15	3	the	the	DT
cord-355758-tk7eturq	15	4	finding	finding	NN
cord-355758-tk7eturq	15	5	that	that	IN
cord-355758-tk7eturq	15	6	the	the	DT
cord-355758-tk7eturq	15	7	gene	gene	NN
cord-355758-tk7eturq	15	8	encoding	encode	VBG
cord-355758-tk7eturq	15	9	Spike	Spike	NNP
cord-355758-tk7eturq	15	10	protein	protein	NN
cord-355758-tk7eturq	15	11	has	have	VBZ
cord-355758-tk7eturq	15	12	been	be	VBN
cord-355758-tk7eturq	15	13	a	a	DT
cord-355758-tk7eturq	15	14	target	target	NN
cord-355758-tk7eturq	15	15	of	of	IN
cord-355758-tk7eturq	15	16	both	both	DT
cord-355758-tk7eturq	15	17	purifying	purifying	JJ
cord-355758-tk7eturq	15	18	and	and	CC
cord-355758-tk7eturq	15	19	positive	positive	JJ
cord-355758-tk7eturq	15	20	selection	selection	NN
cord-355758-tk7eturq	15	21	.	.	.
cord-355758-tk7eturq	16	1	In	in	IN
cord-355758-tk7eturq	16	2	addition	addition	NN
cord-355758-tk7eturq	16	3	,	,	,
cord-355758-tk7eturq	16	4	we	-PRON-	PRP
cord-355758-tk7eturq	16	5	find	find	VBP
cord-355758-tk7eturq	16	6	other	other	JJ
cord-355758-tk7eturq	16	7	likely	likely	JJ
cord-355758-tk7eturq	16	8	targets	target	NNS
cord-355758-tk7eturq	16	9	of	of	IN
cord-355758-tk7eturq	16	10	positive	positive	JJ
cord-355758-tk7eturq	16	11	selection	selection	NN
cord-355758-tk7eturq	16	12	within	within	IN
cord-355758-tk7eturq	16	13	the	the	DT
cord-355758-tk7eturq	16	14	genome	genome	NN
cord-355758-tk7eturq	16	15	of	of	IN
cord-355758-tk7eturq	16	16	SARS	SARS	NNP
cord-355758-tk7eturq	16	17	-	-	HYPH
cord-355758-tk7eturq	16	18	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	16	19	,	,	,
cord-355758-tk7eturq	16	20	specifically	specifically	RB
cord-355758-tk7eturq	16	21	within	within	IN
cord-355758-tk7eturq	16	22	the	the	DT
cord-355758-tk7eturq	16	23	genes	gene	NNS
cord-355758-tk7eturq	16	24	encoding	encode	VBG
cord-355758-tk7eturq	16	25	Nsp4	Nsp4	NNP
cord-355758-tk7eturq	16	26	and	and	CC
cord-355758-tk7eturq	16	27	Nsp16	Nsp16	NNP
cord-355758-tk7eturq	16	28	.	.	.
cord-355758-tk7eturq	17	1	Homology	homology	NN
cord-355758-tk7eturq	17	2	-	-	HYPH
cord-355758-tk7eturq	17	3	directed	direct	VBN
cord-355758-tk7eturq	17	4	modeling	modeling	NN
cord-355758-tk7eturq	17	5	indicates	indicate	VBZ
cord-355758-tk7eturq	17	6	no	no	DT
cord-355758-tk7eturq	17	7	change	change	NN
cord-355758-tk7eturq	17	8	in	in	IN
cord-355758-tk7eturq	17	9	either	either	CC
cord-355758-tk7eturq	17	10	Nsp4	Nsp4	NNP
cord-355758-tk7eturq	17	11	or	or	CC
cord-355758-tk7eturq	17	12	Nsp16	Nsp16	NNP
cord-355758-tk7eturq	17	13	protein	protein	NN
cord-355758-tk7eturq	17	14	structure	structure	NN
cord-355758-tk7eturq	17	15	relative	relative	JJ
cord-355758-tk7eturq	17	16	to	to	IN
cord-355758-tk7eturq	17	17	the	the	DT
cord-355758-tk7eturq	17	18	most	most	RBS
cord-355758-tk7eturq	17	19	recent	recent	JJ
cord-355758-tk7eturq	17	20	common	common	JJ
cord-355758-tk7eturq	17	21	ancestor	ancestor	NN
cord-355758-tk7eturq	17	22	.	.	.
cord-355758-tk7eturq	18	1	Thermodynamic	thermodynamic	JJ
cord-355758-tk7eturq	18	2	modeling	modeling	NN
cord-355758-tk7eturq	18	3	of	of	IN
cord-355758-tk7eturq	18	4	RNA	RNA	NNP
cord-355758-tk7eturq	18	5	stability	stability	NN
cord-355758-tk7eturq	18	6	and	and	CC
cord-355758-tk7eturq	18	7	structure	structure	NN
cord-355758-tk7eturq	18	8	,	,	,
cord-355758-tk7eturq	18	9	however	however	RB
cord-355758-tk7eturq	18	10	,	,	,
cord-355758-tk7eturq	18	11	indicates	indicate	VBZ
cord-355758-tk7eturq	18	12	that	that	IN
cord-355758-tk7eturq	18	13	RNA	RNA	NNP
cord-355758-tk7eturq	18	14	secondary	secondary	JJ
cord-355758-tk7eturq	18	15	structure	structure	NN
cord-355758-tk7eturq	18	16	within	within	IN
cord-355758-tk7eturq	18	17	both	both	DT
cord-355758-tk7eturq	18	18	genes	gene	NNS
cord-355758-tk7eturq	18	19	in	in	IN
cord-355758-tk7eturq	18	20	the	the	DT
cord-355758-tk7eturq	18	21	SARS	SARS	NNP
cord-355758-tk7eturq	18	22	-	-	HYPH
cord-355758-tk7eturq	18	23	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	18	24	genome	genome	NN
cord-355758-tk7eturq	18	25	differs	differ	VBZ
cord-355758-tk7eturq	18	26	from	from	IN
cord-355758-tk7eturq	18	27	those	those	DT
cord-355758-tk7eturq	18	28	of	of	IN
cord-355758-tk7eturq	18	29	RaTG13	RaTG13	NNP
cord-355758-tk7eturq	18	30	,	,	,
cord-355758-tk7eturq	18	31	the	the	DT
cord-355758-tk7eturq	18	32	reconstructed	reconstruct	VBN
cord-355758-tk7eturq	18	33	common	common	JJ
cord-355758-tk7eturq	18	34	ancestor	ancestor	NN
cord-355758-tk7eturq	18	35	,	,	,
cord-355758-tk7eturq	18	36	and	and	CC
cord-355758-tk7eturq	18	37	Pan	Pan	NNP
cord-355758-tk7eturq	18	38	-	-	HYPH
cord-355758-tk7eturq	18	39	CoV	CoV	NNP
cord-355758-tk7eturq	18	40	-	-	HYPH
cord-355758-tk7eturq	18	41	GD	GD	NNP
cord-355758-tk7eturq	18	42	(	(	-LRB-
cord-355758-tk7eturq	18	43	Guangdong	Guangdong	NNP
cord-355758-tk7eturq	18	44	)	)	-RRB-
cord-355758-tk7eturq	18	45	.	.	.
cord-355758-tk7eturq	19	1	These	these	DT
cord-355758-tk7eturq	19	2	SARS	SARS	NNP
cord-355758-tk7eturq	19	3	-	-	HYPH
cord-355758-tk7eturq	19	4	CoV-2-specific	CoV-2-specific	NNP
cord-355758-tk7eturq	19	5	mutations	mutation	NNS
cord-355758-tk7eturq	19	6	may	may	MD
cord-355758-tk7eturq	19	7	affect	affect	VB
cord-355758-tk7eturq	19	8	molecular	molecular	JJ
cord-355758-tk7eturq	19	9	processes	process	NNS
cord-355758-tk7eturq	19	10	mediated	mediate	VBN
cord-355758-tk7eturq	19	11	by	by	IN
cord-355758-tk7eturq	19	12	the	the	DT
cord-355758-tk7eturq	19	13	positive	positive	JJ
cord-355758-tk7eturq	19	14	or	or	CC
cord-355758-tk7eturq	19	15	negative	negative	JJ
cord-355758-tk7eturq	19	16	RNA	RNA	NNP
cord-355758-tk7eturq	19	17	molecules	molecule	NNS
cord-355758-tk7eturq	19	18	,	,	,
cord-355758-tk7eturq	19	19	including	include	VBG
cord-355758-tk7eturq	19	20	transcription	transcription	NN
cord-355758-tk7eturq	19	21	,	,	,
cord-355758-tk7eturq	19	22	translation	translation	NN
cord-355758-tk7eturq	19	23	,	,	,
cord-355758-tk7eturq	19	24	RNA	RNA	NNP
cord-355758-tk7eturq	19	25	stability	stability	NN
cord-355758-tk7eturq	19	26	,	,	,
cord-355758-tk7eturq	19	27	and	and	CC
cord-355758-tk7eturq	19	28	evasion	evasion	NN
cord-355758-tk7eturq	19	29	of	of	IN
cord-355758-tk7eturq	19	30	the	the	DT
cord-355758-tk7eturq	19	31	host	host	NN
cord-355758-tk7eturq	19	32	innate	innate	JJ
cord-355758-tk7eturq	19	33	immune	immune	JJ
cord-355758-tk7eturq	19	34	system	system	NN
cord-355758-tk7eturq	19	35	.	.	.
cord-355758-tk7eturq	20	1	Our	-PRON-	PRP$
cord-355758-tk7eturq	20	2	results	result	NNS
cord-355758-tk7eturq	20	3	highlight	highlight	VBP
cord-355758-tk7eturq	20	4	the	the	DT
cord-355758-tk7eturq	20	5	importance	importance	NN
cord-355758-tk7eturq	20	6	of	of	IN
cord-355758-tk7eturq	20	7	considering	consider	VBG
cord-355758-tk7eturq	20	8	mutations	mutation	NNS
cord-355758-tk7eturq	20	9	in	in	IN
cord-355758-tk7eturq	20	10	viral	viral	JJ
cord-355758-tk7eturq	20	11	genomes	genome	NNS
cord-355758-tk7eturq	20	12	not	not	RB
cord-355758-tk7eturq	20	13	only	only	RB
cord-355758-tk7eturq	20	14	from	from	IN
cord-355758-tk7eturq	20	15	the	the	DT
cord-355758-tk7eturq	20	16	perspective	perspective	NN
cord-355758-tk7eturq	20	17	of	of	IN
cord-355758-tk7eturq	20	18	their	-PRON-	PRP$
cord-355758-tk7eturq	20	19	impact	impact	NN
cord-355758-tk7eturq	20	20	on	on	IN
cord-355758-tk7eturq	20	21	protein	protein	NN
cord-355758-tk7eturq	20	22	structure	structure	NN
cord-355758-tk7eturq	20	23	,	,	,
cord-355758-tk7eturq	20	24	but	but	CC
cord-355758-tk7eturq	20	25	also	also	RB
cord-355758-tk7eturq	20	26	how	how	WRB
cord-355758-tk7eturq	20	27	they	-PRON-	PRP
cord-355758-tk7eturq	20	28	may	may	MD
cord-355758-tk7eturq	20	29	impact	impact	VB
cord-355758-tk7eturq	20	30	other	other	JJ
cord-355758-tk7eturq	20	31	molecular	molecular	JJ
cord-355758-tk7eturq	20	32	processes	process	NNS
cord-355758-tk7eturq	20	33	critical	critical	JJ
cord-355758-tk7eturq	20	34	to	to	IN
cord-355758-tk7eturq	20	35	the	the	DT
cord-355758-tk7eturq	20	36	viral	viral	JJ
cord-355758-tk7eturq	20	37	life	life	NN
cord-355758-tk7eturq	20	38	cycle	cycle	NN
cord-355758-tk7eturq	20	39	.	.	.
cord-355758-tk7eturq	21	1	An	an	DT
cord-355758-tk7eturq	21	2	important	important	JJ
cord-355758-tk7eturq	21	3	challenge	challenge	NN
cord-355758-tk7eturq	21	4	in	in	IN
cord-355758-tk7eturq	21	5	understanding	understand	VBG
cord-355758-tk7eturq	21	6	zoonotic	zoonotic	JJ
cord-355758-tk7eturq	21	7	events	event	NNS
cord-355758-tk7eturq	21	8	is	be	VBZ
cord-355758-tk7eturq	21	9	identifying	identify	VBG
cord-355758-tk7eturq	21	10	the	the	DT
cord-355758-tk7eturq	21	11	genetic	genetic	JJ
cord-355758-tk7eturq	21	12	changes	change	NNS
cord-355758-tk7eturq	21	13	that	that	WDT
cord-355758-tk7eturq	21	14	To	to	TO
cord-355758-tk7eturq	21	15	identify	identify	VB
cord-355758-tk7eturq	21	16	branch	branch	NN
cord-355758-tk7eturq	21	17	specific	specific	JJ
cord-355758-tk7eturq	21	18	positive	positive	JJ
cord-355758-tk7eturq	21	19	selection	selection	NN
cord-355758-tk7eturq	21	20	,	,	,
cord-355758-tk7eturq	21	21	it	-PRON-	PRP
cord-355758-tk7eturq	21	22	is	be	VBZ
cord-355758-tk7eturq	21	23	necessary	necessary	JJ
cord-355758-tk7eturq	21	24	to	to	TO
cord-355758-tk7eturq	21	25	obtain	obtain	VB
cord-355758-tk7eturq	21	26	a	a	DT
cord-355758-tk7eturq	21	27	query	query	NN
cord-355758-tk7eturq	21	28	and	and	CC
cord-355758-tk7eturq	21	29	a	a	DT
cord-355758-tk7eturq	21	30	reference	reference	NN
cord-355758-tk7eturq	21	31	102	102	CD
cord-355758-tk7eturq	21	32	alignment	alignment	NN
cord-355758-tk7eturq	21	33	.	.	.
cord-355758-tk7eturq	22	1	We	-PRON-	PRP
cord-355758-tk7eturq	22	2	downloaded	download	VBD
cord-355758-tk7eturq	22	3	six	six	CD
cord-355758-tk7eturq	22	4	high	high	JJ
cord-355758-tk7eturq	22	5	quality	quality	NN
cord-355758-tk7eturq	22	6	reference	reference	NN
cord-355758-tk7eturq	22	7	genomes	genome	NNS
cord-355758-tk7eturq	22	8	from	from	IN
cord-355758-tk7eturq	22	9	the	the	DT
cord-355758-tk7eturq	22	10	subgenus	subgenus	JJ
cord-355758-tk7eturq	22	11	Sarbecovirus	Sarbecovirus	NNP
cord-355758-tk7eturq	22	12	103	103	CD
cord-355758-tk7eturq	22	13	(	(	-LRB-
cord-355758-tk7eturq	22	14	Table	table	NN
cord-355758-tk7eturq	22	15	1	1	CD
cord-355758-tk7eturq	22	16	)	)	-RRB-
cord-355758-tk7eturq	22	17	.	.	.
cord-355758-tk7eturq	23	1	Next	next	RB
cord-355758-tk7eturq	23	2	,	,	,
cord-355758-tk7eturq	23	3	we	-PRON-	PRP
cord-355758-tk7eturq	23	4	used	use	VBD
cord-355758-tk7eturq	23	5	MAFFT	MAFFT	NNP
cord-355758-tk7eturq	23	6	(	(	-LRB-
cord-355758-tk7eturq	23	7	Katoh	Katoh	NNP
cord-355758-tk7eturq	23	8	&	&	CC
cord-355758-tk7eturq	23	9	Standley	Standley	NNP
cord-355758-tk7eturq	23	10	,	,	,
cord-355758-tk7eturq	23	11	2013	2013	CD
cord-355758-tk7eturq	23	12	)	)	-RRB-
cord-355758-tk7eturq	24	1	(	(	-LRB-
cord-355758-tk7eturq	24	2	Kearse	Kearse	NNP
cord-355758-tk7eturq	24	3	et	et	FW
cord-355758-tk7eturq	24	4	al	al	NNP
cord-355758-tk7eturq	24	5	.	.	NNP
cord-355758-tk7eturq	24	6	,	,	,
cord-355758-tk7eturq	24	7	2012	2012	CD
cord-355758-tk7eturq	24	8	)	)	-RRB-
cord-355758-tk7eturq	24	9	with	with	IN
cord-355758-tk7eturq	24	10	default	default	NN
cord-355758-tk7eturq	24	11	settings	setting	NNS
cord-355758-tk7eturq	24	12	to	to	TO
cord-355758-tk7eturq	24	13	build	build	VB
cord-355758-tk7eturq	24	14	a	a	DT
cord-355758-tk7eturq	24	15	sequence	sequence	NN
cord-355758-tk7eturq	24	16	alignment	alignment	NN
cord-355758-tk7eturq	24	17	.	.	.
cord-355758-tk7eturq	25	1	Next	next	RB
cord-355758-tk7eturq	25	2	,	,	,
cord-355758-tk7eturq	25	3	we	-PRON-	PRP
cord-355758-tk7eturq	25	4	refined	refine	VBD
cord-355758-tk7eturq	25	5	the	the	DT
cord-355758-tk7eturq	25	6	105	105	CD
cord-355758-tk7eturq	25	7	alignment	alignment	NN
cord-355758-tk7eturq	25	8	using	use	VBG
cord-355758-tk7eturq	25	9	a	a	DT
cord-355758-tk7eturq	25	10	gene	gene	NN
cord-355758-tk7eturq	25	11	by	by	IN
cord-355758-tk7eturq	25	12	gene	gene	NN
cord-355758-tk7eturq	25	13	procedure	procedure	NN
cord-355758-tk7eturq	25	14	.	.	.
cord-355758-tk7eturq	26	1	foreground	foreground	NNP
cord-355758-tk7eturq	26	2	branch	branch	NN
cord-355758-tk7eturq	26	3	is	be	VBZ
cord-355758-tk7eturq	26	4	evolving	evolve	VBG
cord-355758-tk7eturq	26	5	at	at	IN
cord-355758-tk7eturq	26	6	faster	fast	JJR
cord-355758-tk7eturq	26	7	rates	rate	NNS
cord-355758-tk7eturq	26	8	than	than	IN
cord-355758-tk7eturq	26	9	the	the	DT
cord-355758-tk7eturq	26	10	expectation	expectation	NN
cord-355758-tk7eturq	26	11	from	from	IN
cord-355758-tk7eturq	26	12	the	the	DT
cord-355758-tk7eturq	26	13	background	background	NN
cord-355758-tk7eturq	26	14	species	specie	NNS
cord-355758-tk7eturq	26	15	.	.	.
cord-355758-tk7eturq	27	1	111	111	CD
cord-355758-tk7eturq	28	1	We	-PRON-	PRP
cord-355758-tk7eturq	28	2	performed	perform	VBD
cord-355758-tk7eturq	28	3	a	a	DT
cord-355758-tk7eturq	28	4	selection	selection	NN
cord-355758-tk7eturq	28	5	analysis	analysis	NN
cord-355758-tk7eturq	28	6	on	on	IN
cord-355758-tk7eturq	28	7	sliding	slide	VBG
cord-355758-tk7eturq	28	8	windows	window	NNS
cord-355758-tk7eturq	28	9	of	of	IN
cord-355758-tk7eturq	28	10	300	300	CD
cord-355758-tk7eturq	28	11	bp	bp	NNS
cord-355758-tk7eturq	28	12	with	with	IN
cord-355758-tk7eturq	28	13	a	a	DT
cord-355758-tk7eturq	28	14	step	step	NN
cord-355758-tk7eturq	28	15	of	of	IN
cord-355758-tk7eturq	28	16	150	150	CD
cord-355758-tk7eturq	28	17	bp	bp	NNS
cord-355758-tk7eturq	28	18	along	along	IN
cord-355758-tk7eturq	28	19	a	a	DT
cord-355758-tk7eturq	28	20	112	112	CD
cord-355758-tk7eturq	28	21	sequence	sequence	NN
cord-355758-tk7eturq	28	22	alignment	alignment	NN
cord-355758-tk7eturq	28	23	of	of	IN
cord-355758-tk7eturq	28	24	5	5	CD
cord-355758-tk7eturq	28	25	reference	reference	NN
cord-355758-tk7eturq	28	26	genome	genome	NN
cord-355758-tk7eturq	28	27	sequences	sequence	NNS
cord-355758-tk7eturq	28	28	of	of	IN
cord-355758-tk7eturq	28	29	coronaviruses	coronaviruse	NNS
cord-355758-tk7eturq	28	30	of	of	IN
cord-355758-tk7eturq	28	31	the	the	DT
cord-355758-tk7eturq	28	32	subgenus	subgenus	NN
cord-355758-tk7eturq	28	33	113	113	CD
cord-355758-tk7eturq	28	34	Sarbecovirus	Sarbecovirus	NNP
cord-355758-tk7eturq	28	35	and	and	CC
cord-355758-tk7eturq	28	36	two	two	CD
cord-355758-tk7eturq	28	37	sequences	sequence	NNS
cord-355758-tk7eturq	28	38	of	of	IN
cord-355758-tk7eturq	28	39	Pangolin	Pangolin	NNP
cord-355758-tk7eturq	28	40	Coronavirus	Coronavirus	NNP
cord-355758-tk7eturq	28	41	recently	recently	RB
cord-355758-tk7eturq	28	42	published	publish	VBD
cord-355758-tk7eturq	28	43	(	(	-LRB-
cord-355758-tk7eturq	28	44	Liu	Liu	NNP
cord-355758-tk7eturq	28	45	,	,	,
cord-355758-tk7eturq	28	46	Chen	Chen	NNP
cord-355758-tk7eturq	28	47	&	&	CC
cord-355758-tk7eturq	28	48	Chen	Chen	NNP
cord-355758-tk7eturq	28	49	,	,	,
cord-355758-tk7eturq	28	50	114	114	CD
cord-355758-tk7eturq	28	51	2019	2019	CD
cord-355758-tk7eturq	28	52	;	;	.
cord-355758-tk7eturq	29	1	Lam	Lam	NNP
cord-355758-tk7eturq	29	2	et	et	NNP
cord-355758-tk7eturq	29	3	al	al	NNP
cord-355758-tk7eturq	29	4	.	.	NNP
cord-355758-tk7eturq	29	5	,	,	,
cord-355758-tk7eturq	29	6	2020	2020	CD
cord-355758-tk7eturq	29	7	)	)	-RRB-
cord-355758-tk7eturq	29	8	.	.	.
cord-355758-tk7eturq	30	1	This	this	DT
cord-355758-tk7eturq	30	2	procedure	procedure	NN
cord-355758-tk7eturq	30	3	generates	generate	VBZ
cord-355758-tk7eturq	30	4	partitions	partition	NNS
cord-355758-tk7eturq	30	5	where	where	WRB
cord-355758-tk7eturq	30	6	a	a	DT
cord-355758-tk7eturq	30	7	tree	tree	NN
cord-355758-tk7eturq	30	8	topology	topology	NN
cord-355758-tk7eturq	30	9	can	can	MD
cord-355758-tk7eturq	30	10	be	be	VB
cord-355758-tk7eturq	30	11	fitted	fit	VBN
cord-355758-tk7eturq	30	12	.	.	.
cord-355758-tk7eturq	31	1	115	115	CD
cord-355758-tk7eturq	32	1	To	to	TO
cord-355758-tk7eturq	32	2	investigate	investigate	VB
cord-355758-tk7eturq	32	3	the	the	DT
cord-355758-tk7eturq	32	4	extent	extent	NN
cord-355758-tk7eturq	32	5	of	of	IN
cord-355758-tk7eturq	32	6	positive	positive	JJ
cord-355758-tk7eturq	32	7	selection	selection	NN
cord-355758-tk7eturq	32	8	or	or	CC
cord-355758-tk7eturq	32	9	branches	branch	NNS
cord-355758-tk7eturq	32	10	with	with	IN
cord-355758-tk7eturq	32	11	long	long	JJ
cord-355758-tk7eturq	32	12	substitution	substitution	NN
cord-355758-tk7eturq	32	13	rates	rate	NNS
cord-355758-tk7eturq	32	14	along	along	IN
cord-355758-tk7eturq	32	15	the	the	DT
cord-355758-tk7eturq	32	16	116	116	CD
cord-355758-tk7eturq	32	17	SARS	SARS	NNP
cord-355758-tk7eturq	32	18	-	-	HYPH
cord-355758-tk7eturq	32	19	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	32	20	genome	genome	NN
cord-355758-tk7eturq	32	21	,	,	,
cord-355758-tk7eturq	32	22	we	-PRON-	PRP
cord-355758-tk7eturq	32	23	used	use	VBD
cord-355758-tk7eturq	32	24	a	a	DT
cord-355758-tk7eturq	32	25	branch	branch	NN
cord-355758-tk7eturq	32	26	-	-	HYPH
cord-355758-tk7eturq	32	27	specific	specific	JJ
cord-355758-tk7eturq	32	28	method	method	NN
cord-355758-tk7eturq	32	29	known	know	VBN
cord-355758-tk7eturq	32	30	as	as	IN
cord-355758-tk7eturq	32	31	adaptiPhy	adaptiPhy	``
cord-355758-tk7eturq	32	32	that	that	WDT
cord-355758-tk7eturq	32	33	was	be	VBD
cord-355758-tk7eturq	32	34	initially	initially	RB
cord-355758-tk7eturq	32	35	Pa_CoV_Guangxi_P4L	Pa_CoV_Guangxi_P4L	NNP
cord-355758-tk7eturq	32	36	)	)	-RRB-
cord-355758-tk7eturq	32	37	,	,	.
cord-355758-tk7eturq	33	1	(	(	-LRB-
cord-355758-tk7eturq	33	2	Bat_CoV_LYRa11	Bat_CoV_LYRa11	NNP
cord-355758-tk7eturq	33	3	,	,	,
cord-355758-tk7eturq	33	4	SARS_CoV	SARS_CoV	NNP
cord-355758-tk7eturq	33	5	)	)	-RRB-
cord-355758-tk7eturq	33	6	)	)	-RRB-
cord-355758-tk7eturq	33	7	,	,	,
cord-355758-tk7eturq	33	8	Bat_CoV_BM48	Bat_CoV_BM48	NNP
cord-355758-tk7eturq	33	9	)	)	-RRB-
cord-355758-tk7eturq	33	10	.	.	.
cord-355758-tk7eturq	34	1	This	this	DT
cord-355758-tk7eturq	34	2	method	method	NN
cord-355758-tk7eturq	34	3	is	be	VBZ
cord-355758-tk7eturq	34	4	131	131	CD
cord-355758-tk7eturq	34	5	highly	highly	RB
cord-355758-tk7eturq	34	6	sensitive	sensitive	JJ
cord-355758-tk7eturq	34	7	and	and	CC
cord-355758-tk7eturq	34	8	specific	specific	JJ
cord-355758-tk7eturq	34	9	and	and	CC
cord-355758-tk7eturq	34	10	can	can	MD
cord-355758-tk7eturq	34	11	differentiate	differentiate	VB
cord-355758-tk7eturq	34	12	between	between	IN
cord-355758-tk7eturq	34	13	positive	positive	JJ
cord-355758-tk7eturq	34	14	selection	selection	NN
cord-355758-tk7eturq	34	15	and	and	CC
cord-355758-tk7eturq	34	16	relaxation	relaxation	NN
cord-355758-tk7eturq	34	17	of	of	IN
cord-355758-tk7eturq	34	18	132	132	CD
cord-355758-tk7eturq	34	19	constraint	constraint	NN
cord-355758-tk7eturq	34	20	.	.	.
cord-355758-tk7eturq	35	1	AdaptiPhy	AdaptiPhy	NNP
cord-355758-tk7eturq	35	2	requires	require	VBZ
cord-355758-tk7eturq	35	3	at	at	IN
cord-355758-tk7eturq	35	4	least	least	JJS
cord-355758-tk7eturq	35	5	3	3	CD
cord-355758-tk7eturq	35	6	kb	kb	NNP
cord-355758-tk7eturq	35	7	reference	reference	NN
cord-355758-tk7eturq	35	8	alignment	alignment	NN
cord-355758-tk7eturq	35	9	for	for	IN
cord-355758-tk7eturq	35	10	each	each	DT
cord-355758-tk7eturq	35	11	species	specie	NNS
cord-355758-tk7eturq	35	12	that	that	WDT
cord-355758-tk7eturq	35	13	is	be	VBZ
cord-355758-tk7eturq	35	14	used	use	VBN
cord-355758-tk7eturq	35	15	as	as	IN
cord-355758-tk7eturq	35	16	a	a	DT
cord-355758-tk7eturq	35	17	133	133	CD
cord-355758-tk7eturq	35	18	putatively	putatively	RB
cord-355758-tk7eturq	35	19	neutral	neutral	JJ
cord-355758-tk7eturq	35	20	proxy	proxy	NN
cord-355758-tk7eturq	35	21	for	for	IN
cord-355758-tk7eturq	35	22	computing	compute	VBG
cord-355758-tk7eturq	35	23	substitution	substitution	NN
cord-355758-tk7eturq	35	24	rates	rate	NNS
cord-355758-tk7eturq	35	25	.	.	.
cord-355758-tk7eturq	36	1	Viruses	virus	NNS
cord-355758-tk7eturq	36	2	'	'	POS
cord-355758-tk7eturq	36	3	genomes	genome	NNS
cord-355758-tk7eturq	36	4	lack	lack	VBP
cord-355758-tk7eturq	36	5	non	non	JJ
cord-355758-tk7eturq	36	6	-	-	JJ
cord-355758-tk7eturq	36	7	functional	functional	JJ
cord-355758-tk7eturq	36	8	134	134	CD
cord-355758-tk7eturq	36	9	regions	region	NNS
cord-355758-tk7eturq	36	10	,	,	,
cord-355758-tk7eturq	36	11	therefore	therefore	RB
cord-355758-tk7eturq	36	12	,	,	,
cord-355758-tk7eturq	36	13	the	the	DT
cord-355758-tk7eturq	36	14	most	most	RBS
cord-355758-tk7eturq	36	15	reasonable	reasonable	JJ
cord-355758-tk7eturq	36	16	proxy	proxy	NN
cord-355758-tk7eturq	36	17	for	for	IN
cord-355758-tk7eturq	36	18	neutral	neutral	JJ
cord-355758-tk7eturq	36	19	evolution	evolution	NN
cord-355758-tk7eturq	36	20	has	have	VBZ
cord-355758-tk7eturq	36	21	to	to	TO
cord-355758-tk7eturq	36	22	be	be	VB
cord-355758-tk7eturq	36	23	found	find	VBN
cord-355758-tk7eturq	36	24	in	in	IN
cord-355758-tk7eturq	36	25	the	the	DT
cord-355758-tk7eturq	36	26	regions	region	NNS
cord-355758-tk7eturq	36	27	135	135	CD
cord-355758-tk7eturq	36	28	outside	outside	IN
cord-355758-tk7eturq	36	29	the	the	DT
cord-355758-tk7eturq	36	30	query	query	NN
cord-355758-tk7eturq	36	31	window	window	NN
cord-355758-tk7eturq	36	32	.	.	.
cord-355758-tk7eturq	37	1	To	to	TO
cord-355758-tk7eturq	37	2	do	do	VB
cord-355758-tk7eturq	37	3	this	this	DT
cord-355758-tk7eturq	37	4	,	,	,
cord-355758-tk7eturq	37	5	we	-PRON-	PRP
cord-355758-tk7eturq	37	6	concatenated	concatenate	VBD
cord-355758-tk7eturq	37	7	twenty	twenty	CD
cord-355758-tk7eturq	37	8	regions	region	NNS
cord-355758-tk7eturq	37	9	of	of	IN
cord-355758-tk7eturq	37	10	300	300	CD
cord-355758-tk7eturq	37	11	bp	bp	NNS
cord-355758-tk7eturq	37	12	of	of	IN
cord-355758-tk7eturq	37	13	the	the	DT
cord-355758-tk7eturq	37	14	viral	viral	JJ
cord-355758-tk7eturq	37	15	136	136	CD
cord-355758-tk7eturq	37	16	genome	genome	NN
cord-355758-tk7eturq	37	17	alignment	alignment	NN
cord-355758-tk7eturq	37	18	that	that	WDT
cord-355758-tk7eturq	37	19	were	be	VBD
cord-355758-tk7eturq	37	20	drawn	draw	VBN
cord-355758-tk7eturq	37	21	randomly	randomly	RB
cord-355758-tk7eturq	37	22	with	with	IN
cord-355758-tk7eturq	37	23	replacement	replacement	NN
cord-355758-tk7eturq	37	24	from	from	IN
cord-355758-tk7eturq	37	25	the	the	DT
cord-355758-tk7eturq	37	26	entire	entire	JJ
cord-355758-tk7eturq	37	27	genome	genome	NN
cord-355758-tk7eturq	37	28	137	137	CD
cord-355758-tk7eturq	37	29	alignment	alignment	NN
cord-355758-tk7eturq	37	30	.	.	.
cord-355758-tk7eturq	38	1	Then	then	RB
cord-355758-tk7eturq	38	2	,	,	,
cord-355758-tk7eturq	38	3	for	for	IN
cord-355758-tk7eturq	38	4	each	each	DT
cord-355758-tk7eturq	38	5	query	query	NN
cord-355758-tk7eturq	38	6	alignment	alignment	NN
cord-355758-tk7eturq	38	7	,	,	,
cord-355758-tk7eturq	38	8	we	-PRON-	PRP
cord-355758-tk7eturq	38	9	built	build	VBD
cord-355758-tk7eturq	38	10	a	a	DT
cord-355758-tk7eturq	38	11	reference	reference	NN
cord-355758-tk7eturq	38	12	alignment	alignment	NN
cord-355758-tk7eturq	38	13	of	of	IN
cord-355758-tk7eturq	38	14	6	6	CD
cord-355758-tk7eturq	38	15	kb	kb	NNS
cord-355758-tk7eturq	38	16	as	as	IN
cord-355758-tk7eturq	38	17	it	-PRON-	PRP
cord-355758-tk7eturq	38	18	produces	produce	VBZ
cord-355758-tk7eturq	38	19	138	138	CD
cord-355758-tk7eturq	38	20	a	a	DT
cord-355758-tk7eturq	38	21	stable	stable	JJ
cord-355758-tk7eturq	38	22	evolutionary	evolutionary	JJ
cord-355758-tk7eturq	38	23	standard	standard	NN
cord-355758-tk7eturq	38	24	of	of	IN
cord-355758-tk7eturq	38	25	recombination	recombination	NN
cord-355758-tk7eturq	38	26	rates	rate	NNS
cord-355758-tk7eturq	38	27	.	.	.
cord-355758-tk7eturq	39	1	To	to	TO
cord-355758-tk7eturq	39	2	control	control	VB
cord-355758-tk7eturq	39	3	for	for	IN
cord-355758-tk7eturq	39	4	the	the	DT
cord-355758-tk7eturq	39	5	stochasticity	stochasticity	NN
cord-355758-tk7eturq	39	6	of	of	IN
cord-355758-tk7eturq	39	7	the	the	DT
cord-355758-tk7eturq	39	8	139	139	CD
cord-355758-tk7eturq	39	9	evolutionary	evolutionary	JJ
cord-355758-tk7eturq	39	10	process	process	NN
cord-355758-tk7eturq	39	11	,	,	,
cord-355758-tk7eturq	39	12	we	-PRON-	PRP
cord-355758-tk7eturq	39	13	run	run	VBP
cord-355758-tk7eturq	39	14	each	each	DT
cord-355758-tk7eturq	39	15	query	query	NN
cord-355758-tk7eturq	39	16	against	against	IN
cord-355758-tk7eturq	39	17	ten	ten	CD
cord-355758-tk7eturq	39	18	bootstrapped	bootstrappe	VBN
cord-355758-tk7eturq	39	19	samples	sample	NNS
cord-355758-tk7eturq	39	20	of	of	IN
cord-355758-tk7eturq	39	21	reference	reference	NN
cord-355758-tk7eturq	39	22	140	140	CD
cord-355758-tk7eturq	39	23	alignments	alignment	NNS
cord-355758-tk7eturq	39	24	.	.	.
cord-355758-tk7eturq	40	1	Finally	finally	RB
cord-355758-tk7eturq	40	2	,	,	,
cord-355758-tk7eturq	40	3	we	-PRON-	PRP
cord-355758-tk7eturq	40	4	used	use	VBD
cord-355758-tk7eturq	40	5	a	a	DT
cord-355758-tk7eturq	40	6	custom	custom	NN
cord-355758-tk7eturq	40	7	R	r	NN
cord-355758-tk7eturq	40	8	script	script	NN
cord-355758-tk7eturq	40	9	to	to	TO
cord-355758-tk7eturq	40	10	compute	compute	VB
cord-355758-tk7eturq	40	11	the	the	DT
cord-355758-tk7eturq	40	12	likelihood	likelihood	NN
cord-355758-tk7eturq	40	13	ratio	ratio	NN
cord-355758-tk7eturq	40	14	,	,	,
cord-355758-tk7eturq	40	15	which	which	WDT
cord-355758-tk7eturq	40	16	was	be	VBD
cord-355758-tk7eturq	40	17	used	use	VBN
cord-355758-tk7eturq	40	18	141	141	CD
cord-355758-tk7eturq	40	19	as	as	IN
cord-355758-tk7eturq	40	20	a	a	DT
cord-355758-tk7eturq	40	21	test	test	NN
cord-355758-tk7eturq	40	22	statistic	statistic	NN
cord-355758-tk7eturq	40	23	for	for	IN
cord-355758-tk7eturq	40	24	a	a	DT
cord-355758-tk7eturq	40	25	chi	chi	JJ
cord-355758-tk7eturq	40	26	-	-	JJ
cord-355758-tk7eturq	40	27	squared	squared	JJ
cord-355758-tk7eturq	40	28	test	test	NN
cord-355758-tk7eturq	40	29	with	with	IN
cord-355758-tk7eturq	40	30	one	one	CD
cord-355758-tk7eturq	40	31	degree	degree	NN
cord-355758-tk7eturq	40	32	of	of	IN
cord-355758-tk7eturq	40	33	freedom	freedom	NN
cord-355758-tk7eturq	40	34	to	to	TO
cord-355758-tk7eturq	40	35	calculate	calculate	VB
cord-355758-tk7eturq	40	36	a	a	DT
cord-355758-tk7eturq	40	37	P	p	NN
cord-355758-tk7eturq	40	38	-	-	HYPH
cord-355758-tk7eturq	40	39	value	value	NN
cord-355758-tk7eturq	40	40	for	for	IN
cord-355758-tk7eturq	40	41	each	each	DT
cord-355758-tk7eturq	40	42	142	142	CD
cord-355758-tk7eturq	40	43	query	query	NN
cord-355758-tk7eturq	40	44	.	.	.
cord-355758-tk7eturq	41	1	Then	then	RB
cord-355758-tk7eturq	41	2	,	,	,
cord-355758-tk7eturq	41	3	we	-PRON-	PRP
cord-355758-tk7eturq	41	4	corrected	correct	VBD
cord-355758-tk7eturq	41	5	the	the	DT
cord-355758-tk7eturq	41	6	distribution	distribution	NN
cord-355758-tk7eturq	41	7	of	of	IN
cord-355758-tk7eturq	41	8	all	all	DT
cord-355758-tk7eturq	41	9	P	p	NN
cord-355758-tk7eturq	41	10	-	-	HYPH
cord-355758-tk7eturq	41	11	values	value	NNS
cord-355758-tk7eturq	41	12	per	per	IN
cord-355758-tk7eturq	41	13	query	query	NN
cord-355758-tk7eturq	41	14	region	region	NN
cord-355758-tk7eturq	41	15	using	use	VBG
cord-355758-tk7eturq	41	16	the	the	DT
cord-355758-tk7eturq	41	17	p.adjust	p.adjust	NNP
cord-355758-tk7eturq	41	18	(	(	-LRB-
cord-355758-tk7eturq	41	19	)	)	-RRB-
cord-355758-tk7eturq	41	20	R	r	NN
cord-355758-tk7eturq	41	21	143	143	CD
cord-355758-tk7eturq	41	22	function	function	NN
cord-355758-tk7eturq	41	23	with	with	IN
cord-355758-tk7eturq	41	24	the	the	DT
cord-355758-tk7eturq	41	25	fdr	fdr	NNP
cord-355758-tk7eturq	41	26	method	method	NN
cord-355758-tk7eturq	41	27	.	.	.
cord-355758-tk7eturq	42	1	Next	next	RB
cord-355758-tk7eturq	42	2	,	,	,
cord-355758-tk7eturq	42	3	we	-PRON-	PRP
cord-355758-tk7eturq	42	4	classified	classify	VBD
cord-355758-tk7eturq	42	5	a	a	DT
cord-355758-tk7eturq	42	6	query	query	NN
cord-355758-tk7eturq	42	7	window	window	NN
cord-355758-tk7eturq	42	8	to	to	TO
cord-355758-tk7eturq	42	9	be	be	VB
cord-355758-tk7eturq	42	10	under	under	IN
cord-355758-tk7eturq	42	11	positive	positive	JJ
cord-355758-tk7eturq	42	12	selection	selection	NN
cord-355758-tk7eturq	42	13	144	144	CD
cord-355758-tk7eturq	42	14	if	if	IN
cord-355758-tk7eturq	42	15	the	the	DT
cord-355758-tk7eturq	42	16	P	p	NN
cord-355758-tk7eturq	42	17	-	-	HYPH
cord-355758-tk7eturq	42	18	adjusted	adjust	VBN
cord-355758-tk7eturq	42	19	value	value	NN
cord-355758-tk7eturq	42	20	was	be	VBD
cord-355758-tk7eturq	42	21	<	<	XX
cord-355758-tk7eturq	42	22	0.05	0.05	CD
cord-355758-tk7eturq	42	23	.	.	.
cord-355758-tk7eturq	43	1	We	-PRON-	PRP
cord-355758-tk7eturq	43	2	were	be	VBD
cord-355758-tk7eturq	43	3	unable	unable	JJ
cord-355758-tk7eturq	43	4	to	to	TO
cord-355758-tk7eturq	43	5	successfully	successfully	RB
cord-355758-tk7eturq	43	6	run	run	VB
cord-355758-tk7eturq	43	7	adaptiPhy	adaptiPhy	NNP
cord-355758-tk7eturq	43	8	on	on	IN
cord-355758-tk7eturq	43	9	two	two	CD
cord-355758-tk7eturq	43	10	145	145	CD
cord-355758-tk7eturq	43	11	windows	window	NNS
cord-355758-tk7eturq	43	12	because	because	IN
cord-355758-tk7eturq	43	13	the	the	DT
cord-355758-tk7eturq	43	14	outgroup	outgroup	NN
cord-355758-tk7eturq	43	15	species	specie	NNS
cord-355758-tk7eturq	43	16	(	(	-LRB-
cord-355758-tk7eturq	43	17	Bat_CoV_BM48	Bat_CoV_BM48	NNP
cord-355758-tk7eturq	43	18	)	)	-RRB-
cord-355758-tk7eturq	43	19	contained	contain	VBD
cord-355758-tk7eturq	43	20	a	a	DT
cord-355758-tk7eturq	43	21	deletion	deletion	NN
cord-355758-tk7eturq	43	22	of	of	IN
cord-355758-tk7eturq	43	23	406	406	CD
cord-355758-tk7eturq	43	24	bp	bp	NNP
cord-355758-tk7eturq	43	25	relative	relative	NN
cord-355758-tk7eturq	43	26	146	146	CD
cord-355758-tk7eturq	43	27	to	to	IN
cord-355758-tk7eturq	43	28	SARS	SARS	NNP
cord-355758-tk7eturq	43	29	-	-	HYPH
cord-355758-tk7eturq	43	30	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	43	31	,	,	,
cord-355758-tk7eturq	43	32	which	which	WDT
cord-355758-tk7eturq	43	33	spans	span	VBZ
cord-355758-tk7eturq	43	34	the	the	DT
cord-355758-tk7eturq	43	35	entire	entire	JJ
cord-355758-tk7eturq	43	36	ORF8	ORF8	NNP
cord-355758-tk7eturq	43	37	.	.	.
cord-355758-tk7eturq	44	1	Next	next	RB
cord-355758-tk7eturq	44	2	,	,	,
cord-355758-tk7eturq	44	3	we	-PRON-	PRP
cord-355758-tk7eturq	44	4	calculated	calculate	VBD
cord-355758-tk7eturq	44	5	the	the	DT
cord-355758-tk7eturq	44	6	distribution	distribution	NN
cord-355758-tk7eturq	44	7	of	of	IN
cord-355758-tk7eturq	44	8	substitution	substitution	NN
cord-355758-tk7eturq	44	9	rates	rate	NNS
cord-355758-tk7eturq	44	10	for	for	IN
cord-355758-tk7eturq	44	11	each	each	DT
cord-355758-tk7eturq	44	12	branch	branch	NN
cord-355758-tk7eturq	44	13	and	and	CC
cord-355758-tk7eturq	44	14	nodes	node	NNS
cord-355758-tk7eturq	44	15	in	in	IN
cord-355758-tk7eturq	44	16	each	each	DT
cord-355758-tk7eturq	44	17	query	query	NN
cord-355758-tk7eturq	44	18	148	148	CD
cord-355758-tk7eturq	44	19	and	and	CC
cord-355758-tk7eturq	44	20	reference	reference	NN
cord-355758-tk7eturq	44	21	sequence	sequence	NN
cord-355758-tk7eturq	44	22	using	use	VBG
cord-355758-tk7eturq	44	23	phyloFit	phyloFit	NNP
cord-355758-tk7eturq	44	24	(	(	-LRB-
cord-355758-tk7eturq	44	25	Hubisz	Hubisz	NNP
cord-355758-tk7eturq	44	26	,	,	,
cord-355758-tk7eturq	44	27	Pollard	Pollard	NNP
cord-355758-tk7eturq	44	28	&	&	CC
cord-355758-tk7eturq	44	29	Siepel	Siepel	NNP
cord-355758-tk7eturq	44	30	,	,	,
cord-355758-tk7eturq	44	31	2011	2011	CD
cord-355758-tk7eturq	45	1	(	(	-LRB-
cord-355758-tk7eturq	45	2	Wong	Wong	NNP
cord-355758-tk7eturq	45	3	&	&	CC
cord-355758-tk7eturq	45	4	Nielsen	Nielsen	NNP
cord-355758-tk7eturq	45	5	,	,	,
cord-355758-tk7eturq	45	6	2004	2004	CD
cord-355758-tk7eturq	45	7	)	)	-RRB-
cord-355758-tk7eturq	45	8	.	.	.
cord-355758-tk7eturq	46	1	To	to	TO
cord-355758-tk7eturq	46	2	test	test	VB
cord-355758-tk7eturq	46	3	for	for	IN
cord-355758-tk7eturq	46	4	conservation	conservation	NN
cord-355758-tk7eturq	46	5	,	,	,
cord-355758-tk7eturq	46	6	we	-PRON-	PRP
cord-355758-tk7eturq	46	7	used	use	VBD
cord-355758-tk7eturq	46	8	the	the	DT
cord-355758-tk7eturq	46	9	phastCons	phastCons	NNP
cord-355758-tk7eturq	46	10	computational	computational	JJ
cord-355758-tk7eturq	46	11	method	method	NN
cord-355758-tk7eturq	46	12	from	from	IN
cord-355758-tk7eturq	46	13	PHAST	PHAST	NNP
cord-355758-tk7eturq	47	1	(	(	-LRB-
cord-355758-tk7eturq	47	2	Siepel	Siepel	NNP
cord-355758-tk7eturq	47	3	et	et	FW
cord-355758-tk7eturq	47	4	 	 	_SP
cord-355758-tk7eturq	47	5	Positive	positive	JJ
cord-355758-tk7eturq	47	6	and	and	CC
cord-355758-tk7eturq	47	7	negative	negative	JJ
cord-355758-tk7eturq	47	8	selection	selection	NN
cord-355758-tk7eturq	47	9	are	be	VBP
cord-355758-tk7eturq	47	10	highly	highly	RB
cord-355758-tk7eturq	47	11	localized	localize	VBN
cord-355758-tk7eturq	47	12	within	within	IN
cord-355758-tk7eturq	47	13	coronavirus	coronavirus	NN
cord-355758-tk7eturq	47	14	genomes	genome	NNS
cord-355758-tk7eturq	47	15	204	204	CD
cord-355758-tk7eturq	48	1	We	-PRON-	PRP
cord-355758-tk7eturq	48	2	tested	test	VBD
cord-355758-tk7eturq	48	3	for	for	IN
cord-355758-tk7eturq	48	4	branch	branch	NN
cord-355758-tk7eturq	48	5	-	-	HYPH
cord-355758-tk7eturq	48	6	specific	specific	JJ
cord-355758-tk7eturq	48	7	selection	selection	NN
cord-355758-tk7eturq	48	8	on	on	IN
cord-355758-tk7eturq	48	9	nucleotide	nucleotide	JJ
cord-355758-tk7eturq	48	10	sequences	sequence	NNS
cord-355758-tk7eturq	48	11	in	in	IN
cord-355758-tk7eturq	48	12	coronavirus	coronavirus	NN
cord-355758-tk7eturq	48	13	genomes	genome	NNS
cord-355758-tk7eturq	48	14	,	,	,
cord-355758-tk7eturq	48	15	The	the	DT
cord-355758-tk7eturq	48	16	fourth	fourth	JJ
cord-355758-tk7eturq	48	17	signal	signal	NN
cord-355758-tk7eturq	48	18	is	be	VBZ
cord-355758-tk7eturq	48	19	located	locate	VBN
cord-355758-tk7eturq	48	20	in	in	IN
cord-355758-tk7eturq	48	21	a	a	DT
cord-355758-tk7eturq	48	22	segment	segment	NN
cord-355758-tk7eturq	48	23	encoding	encode	VBG
cord-355758-tk7eturq	48	24	the	the	DT
cord-355758-tk7eturq	48	25	S2	S2	NNP
cord-355758-tk7eturq	48	26	and	and	CC
cord-355758-tk7eturq	48	27	S2	S2	NNP
cord-355758-tk7eturq	48	28	'	'	''
cord-355758-tk7eturq	48	29	subunits	subunit	NNS
cord-355758-tk7eturq	48	30	that	that	WDT
cord-355758-tk7eturq	48	31	includes	include	VBZ
cord-355758-tk7eturq	48	32	the	the	DT
cord-355758-tk7eturq	48	33	boundary	boundary	JJ
cord-355758-tk7eturq	48	34	region	region	NN
cord-355758-tk7eturq	48	35	between	between	IN
cord-355758-tk7eturq	48	36	the	the	DT
cord-355758-tk7eturq	48	37	S1	S1	NNP
cord-355758-tk7eturq	48	38	and	and	CC
cord-355758-tk7eturq	48	39	the	the	DT
cord-355758-tk7eturq	48	40	S2	s2	NN
cord-355758-tk7eturq	48	41	subunits	subunit	NNS
cord-355758-tk7eturq	48	42	(	(	-LRB-
cord-355758-tk7eturq	48	43	Fig	Fig	NNP
cord-355758-tk7eturq	48	44	1	1	CD
cord-355758-tk7eturq	48	45	)	)	-RRB-
cord-355758-tk7eturq	48	46	,	,	,
cord-355758-tk7eturq	48	47	a	a	DT
cord-355758-tk7eturq	48	48	region	region	NN
cord-355758-tk7eturq	48	49	that	that	WDT
cord-355758-tk7eturq	48	50	includes	include	VBZ
cord-355758-tk7eturq	48	51	the	the	DT
cord-355758-tk7eturq	48	52	Genes	Genes	NNPS
cord-355758-tk7eturq	48	53	encoding	encoding	NN
cord-355758-tk7eturq	48	54	Nsp4	Nsp4	NNP
cord-355758-tk7eturq	48	55	and	and	CC
cord-355758-tk7eturq	48	56	Nsp16	Nsp16	NNP
cord-355758-tk7eturq	48	57	contain	contain	VBP
cord-355758-tk7eturq	48	58	branch	branch	NN
cord-355758-tk7eturq	48	59	-	-	HYPH
cord-355758-tk7eturq	48	60	specific	specific	JJ
cord-355758-tk7eturq	48	61	signals	signal	NNS
cord-355758-tk7eturq	48	62	of	of	IN
cord-355758-tk7eturq	48	63	positive	positive	JJ
cord-355758-tk7eturq	48	64	selection	selection	NN
cord-355758-tk7eturq	49	1	260	260	CD
cord-355758-tk7eturq	50	1	We	-PRON-	PRP
cord-355758-tk7eturq	50	2	also	also	RB
cord-355758-tk7eturq	50	3	detected	detect	VBD
cord-355758-tk7eturq	50	4	two	two	CD
cord-355758-tk7eturq	50	5	shorter	short	JJR
cord-355758-tk7eturq	50	6	signals	signal	NNS
cord-355758-tk7eturq	50	7	of	of	IN
cord-355758-tk7eturq	50	8	positive	positive	JJ
cord-355758-tk7eturq	50	9	selection	selection	NN
cord-355758-tk7eturq	50	10	within	within	IN
cord-355758-tk7eturq	50	11	the	the	DT
cord-355758-tk7eturq	50	12	SARS	SARS	NNP
cord-355758-tk7eturq	50	13	-	-	HYPH
cord-355758-tk7eturq	50	14	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	50	15	261	261	CD
cord-355758-tk7eturq	50	16	genome	genome	NN
cord-355758-tk7eturq	50	17	that	that	WDT
cord-355758-tk7eturq	50	18	are	be	VBP
cord-355758-tk7eturq	50	19	located	locate	VBN
cord-355758-tk7eturq	50	20	outside	outside	RB
cord-355758-tk7eturq	50	21	of	of	IN
cord-355758-tk7eturq	50	22	the	the	DT
cord-355758-tk7eturq	50	23	S	S	NNP
cord-355758-tk7eturq	50	24	gene	gene	NN
cord-355758-tk7eturq	50	25	,	,	,
cord-355758-tk7eturq	50	26	in	in	IN
cord-355758-tk7eturq	50	27	ORF1a	ORF1a	NNP
cord-355758-tk7eturq	51	1	and	and	CC
cord-355758-tk7eturq	51	2	ORF1b	ORF1b	NNP
cord-355758-tk7eturq	52	1	(	(	-LRB-
cord-355758-tk7eturq	52	2	Fig	Fig	NNP
cord-355758-tk7eturq	52	3	1A	1a	NN
cord-355758-tk7eturq	52	4	)	)	-RRB-
cord-355758-tk7eturq	52	5	.	.	.
cord-355758-tk7eturq	53	1	Interestingly	interestingly	RB
cord-355758-tk7eturq	53	2	,	,	,
cord-355758-tk7eturq	53	3	262	262	CD
cord-355758-tk7eturq	53	4	both	both	DT
cord-355758-tk7eturq	53	5	encode	encode	VB
cord-355758-tk7eturq	53	6	small	small	JJ
cord-355758-tk7eturq	53	7	proteins	protein	NNS
cord-355758-tk7eturq	53	8	that	that	WDT
cord-355758-tk7eturq	53	9	contribute	contribute	VBP
cord-355758-tk7eturq	53	10	to	to	IN
cord-355758-tk7eturq	53	11	viral	viral	JJ
cord-355758-tk7eturq	53	12	replication	replication	NN
cord-355758-tk7eturq	53	13	.	.	.
cord-355758-tk7eturq	54	1	The	the	DT
cord-355758-tk7eturq	54	2	first	first	JJ
cord-355758-tk7eturq	54	3	is	be	VBZ
cord-355758-tk7eturq	54	4	Nsp4	Nsp4	NNP
cord-355758-tk7eturq	54	5	,	,	,
cord-355758-tk7eturq	54	6	which	which	WDT
cord-355758-tk7eturq	54	7	encodes	encode	VBZ
cord-355758-tk7eturq	54	8	a	a	DT
cord-355758-tk7eturq	54	9	similarities	similarity	NNS
cord-355758-tk7eturq	54	10	to	to	TO
cord-355758-tk7eturq	54	11	,	,	,
cord-355758-tk7eturq	54	12	but	but	CC
cord-355758-tk7eturq	54	13	also	also	RB
cord-355758-tk7eturq	54	14	notable	notable	JJ
cord-355758-tk7eturq	54	15	differences	difference	NNS
cord-355758-tk7eturq	54	16	from	from	IN
cord-355758-tk7eturq	54	17	,	,	,
cord-355758-tk7eturq	54	18	that	that	DT
cord-355758-tk7eturq	54	19	of	of	IN
cord-355758-tk7eturq	55	1	SARS	SARS	NNP
cord-355758-tk7eturq	55	2	-	-	HYPH
cord-355758-tk7eturq	55	3	Cov-2	Cov-2	NNP
cord-355758-tk7eturq	55	4	(	(	-LRB-
cord-355758-tk7eturq	55	5	Fig	Fig	NNP
cord-355758-tk7eturq	55	6	1	1	CD
cord-355758-tk7eturq	55	7	)	)	-RRB-
cord-355758-tk7eturq	55	8	.	.	.
cord-355758-tk7eturq	56	1	In	in	IN
cord-355758-tk7eturq	56	2	both	both	DT
cord-355758-tk7eturq	56	3	species	specie	NNS
cord-355758-tk7eturq	56	4	,	,	,
cord-355758-tk7eturq	56	5	S	S	NNP
cord-355758-tk7eturq	56	6	CoV	cov	NN
cord-355758-tk7eturq	56	7	-	-	HYPH
cord-355758-tk7eturq	56	8	RaTG13	RaTG13	NNP
cord-355758-tk7eturq	56	9	)	)	-RRB-
cord-355758-tk7eturq	56	10	)	)	-RRB-
cord-355758-tk7eturq	56	11	)	)	-RRB-
cord-355758-tk7eturq	56	12	)	)	-RRB-
cord-355758-tk7eturq	56	13	.	.	.
cord-355758-tk7eturq	57	1	Recombination	recombination	NN
cord-355758-tk7eturq	57	2	from	from	IN
cord-355758-tk7eturq	57	3	a	a	DT
cord-355758-tk7eturq	57	4	divergent	divergent	JJ
cord-355758-tk7eturq	57	5	species	specie	NNS
cord-355758-tk7eturq	57	6	should	should	MD
cord-355758-tk7eturq	57	7	produce	produce	VB
cord-355758-tk7eturq	57	8	an	an	DT
cord-355758-tk7eturq	57	9	incongruent	incongruent	JJ
cord-355758-tk7eturq	57	10	334	334	CD
cord-355758-tk7eturq	57	11	topology	topology	NN
cord-355758-tk7eturq	57	12	in	in	IN
cord-355758-tk7eturq	57	13	one	one	CD
cord-355758-tk7eturq	57	14	or	or	CC
cord-355758-tk7eturq	57	15	more	more	JJR
cord-355758-tk7eturq	57	16	adjacent	adjacent	JJ
cord-355758-tk7eturq	57	17	windows	window	NNS
cord-355758-tk7eturq	57	18	,	,	,
cord-355758-tk7eturq	57	19	revealing	reveal	VBG
cord-355758-tk7eturq	57	20	a	a	DT
cord-355758-tk7eturq	57	21	recombined	recombine	VBN
cord-355758-tk7eturq	57	22	region	region	NN
cord-355758-tk7eturq	57	23	and	and	CC
cord-355758-tk7eturq	57	24	its	-PRON-	PRP$
cord-355758-tk7eturq	57	25	approximate	approximate	JJ
cord-355758-tk7eturq	57	26	335	335	CD
cord-355758-tk7eturq	57	27	breakpoints	breakpoint	NNS
cord-355758-tk7eturq	57	28	.	.	.
cord-355758-tk7eturq	58	1	We	-PRON-	PRP
cord-355758-tk7eturq	58	2	identified	identify	VBD
cord-355758-tk7eturq	58	3	12	12	CD
cord-355758-tk7eturq	58	4	regions	region	NNS
cord-355758-tk7eturq	58	5	where	where	WRB
cord-355758-tk7eturq	58	6	the	the	DT
cord-355758-tk7eturq	58	7	topology	topology	NN
cord-355758-tk7eturq	58	8	differed	differ	VBD
cord-355758-tk7eturq	58	9	from	from	IN
cord-355758-tk7eturq	58	10	the	the	DT
cord-355758-tk7eturq	58	11	expected	expect	VBN
cord-355758-tk7eturq	58	12	(	(	-LRB-
cord-355758-tk7eturq	58	13	Fig	Fig	NNP
cord-355758-tk7eturq	58	14	6	6	CD
cord-355758-tk7eturq	58	15	)	)	-RRB-
cord-355758-tk7eturq	58	16	.	.	.
cord-355758-tk7eturq	59	1	Of	of	IN
cord-355758-tk7eturq	59	2	(	(	-LRB-
cord-355758-tk7eturq	59	3	Fig	Fig	NNP
cord-355758-tk7eturq	59	4	1C	1c	NN
cord-355758-tk7eturq	59	5	and	and	CC
cord-355758-tk7eturq	59	6	3A	3a	NN
cord-355758-tk7eturq	59	7	)	)	-RRB-
cord-355758-tk7eturq	59	8	.	.	.
cord-355758-tk7eturq	60	1	In	in	IN
cord-355758-tk7eturq	60	2	contrast	contrast	NN
cord-355758-tk7eturq	60	3	,	,	,
cord-355758-tk7eturq	60	4	signals	signal	NNS
cord-355758-tk7eturq	60	5	of	of	IN
cord-355758-tk7eturq	60	6	positive	positive	JJ
cord-355758-tk7eturq	60	7	selection	selection	NN
cord-355758-tk7eturq	60	8	in	in	IN
cord-355758-tk7eturq	60	9	407	407	CD
cord-355758-tk7eturq	60	10	SARS	SARS	NNP
cord-355758-tk7eturq	60	11	-	-	HYPH
cord-355758-tk7eturq	60	12	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	60	13	and	and	CC
cord-355758-tk7eturq	60	14	Bat	Bat	NNP
cord-355758-tk7eturq	60	15	-	-	HYPH
cord-355758-tk7eturq	60	16	CoV	cov	NN
cord-355758-tk7eturq	60	17	-	-	HYPH
cord-355758-tk7eturq	60	18	RaTG13	RaTG13	NNP
cord-355758-tk7eturq	60	19	are	be	VBP
cord-355758-tk7eturq	60	20	concentrated	concentrate	VBN
cord-355758-tk7eturq	60	21	in	in	IN
cord-355758-tk7eturq	60	22	the	the	DT
cord-355758-tk7eturq	60	23	domain	domain	NN
cord-355758-tk7eturq	60	24	that	that	WDT
cord-355758-tk7eturq	60	25	mediates	mediate	VBZ
cord-355758-tk7eturq	60	26	binding	bind	VBG
cord-355758-tk7eturq	60	27	to	to	IN
cord-355758-tk7eturq	60	28	the	the	DT
cord-355758-tk7eturq	60	29	408	408	CD
cord-355758-tk7eturq	60	30	host	host	NN
cord-355758-tk7eturq	60	31	receptor	receptor	NN
cord-355758-tk7eturq	60	32	ACE2	ACE2	NNP
cord-355758-tk7eturq	60	33	(	(	-LRB-
cord-355758-tk7eturq	60	34	Fig	Fig	NNP
cord-355758-tk7eturq	60	35	1C	1c	NN
cord-355758-tk7eturq	60	36	and	and	CC
cord-355758-tk7eturq	60	37	3A	3a	NN
cord-355758-tk7eturq	60	38	)	)	-RRB-
cord-355758-tk7eturq	60	39	.	.	.
cord-355758-tk7eturq	61	1	These	these	DT
cord-355758-tk7eturq	61	2	distinct	distinct	JJ
cord-355758-tk7eturq	61	3	distributions	distribution	NNS
cord-355758-tk7eturq	61	4	suggest	suggest	VBP
cord-355758-tk7eturq	61	5	that	that	IN
cord-355758-tk7eturq	61	6	modifications	modification	NNS
cord-355758-tk7eturq	61	7	in	in	IN
cord-355758-tk7eturq	61	8	409	409	CD
cord-355758-tk7eturq	61	9	different	different	JJ
cord-355758-tk7eturq	61	10	aspects	aspect	NNS
cord-355758-tk7eturq	61	11	of	of	IN
cord-355758-tk7eturq	61	12	Spike	Spike	NNP
cord-355758-tk7eturq	61	13	function	function	NN
cord-355758-tk7eturq	61	14	took	take	VBD
cord-355758-tk7eturq	61	15	place	place	NN
cord-355758-tk7eturq	61	16	as	as	IN
cord-355758-tk7eturq	61	17	various	various	JJ
cord-355758-tk7eturq	61	18	coronaviruses	coronaviruse	NNS
cord-355758-tk7eturq	61	19	adapted	adapt	VBN
cord-355758-tk7eturq	61	20	to	to	IN
cord-355758-tk7eturq	61	21	novel	novel	JJ
cord-355758-tk7eturq	61	22	hosts	host	NNS
cord-355758-tk7eturq	61	23	.	.	.
cord-355758-tk7eturq	62	1	In	in	IN
cord-355758-tk7eturq	62	2	Importantly	importantly	RB
cord-355758-tk7eturq	62	3	,	,	,
cord-355758-tk7eturq	62	4	we	-PRON-	PRP
cord-355758-tk7eturq	62	5	also	also	RB
cord-355758-tk7eturq	62	6	detected	detect	VBD
cord-355758-tk7eturq	62	7	signals	signal	NNS
cord-355758-tk7eturq	62	8	of	of	IN
cord-355758-tk7eturq	62	9	positive	positive	JJ
cord-355758-tk7eturq	62	10	selection	selection	NN
cord-355758-tk7eturq	62	11	in	in	IN
cord-355758-tk7eturq	62	12	two	two	CD
cord-355758-tk7eturq	62	13	additional	additional	JJ
cord-355758-tk7eturq	62	14	regions	region	NNS
cord-355758-tk7eturq	62	15	of	of	IN
cord-355758-tk7eturq	62	16	the	the	DT
cord-355758-tk7eturq	62	17	414	414	CD
cord-355758-tk7eturq	62	18	SARS	SARS	NNP
cord-355758-tk7eturq	62	19	-	-	HYPH
cord-355758-tk7eturq	62	20	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	62	21	genome	genome	NN
cord-355758-tk7eturq	62	22	,	,	,
cord-355758-tk7eturq	62	23	specifically	specifically	RB
cord-355758-tk7eturq	62	24	within	within	IN
cord-355758-tk7eturq	62	25	the	the	DT
cord-355758-tk7eturq	62	26	genes	gene	NNS
cord-355758-tk7eturq	62	27	encoding	encode	VBG
cord-355758-tk7eturq	62	28	Nsp4	Nsp4	NNP
cord-355758-tk7eturq	62	29	and	and	CC
cord-355758-tk7eturq	62	30	Nsp16	Nsp16	NNP
cord-355758-tk7eturq	62	31	(	(	-LRB-
cord-355758-tk7eturq	62	32	Fig	Fig	NNP
cord-355758-tk7eturq	62	33	1A	1a	NN
cord-355758-tk7eturq	62	34	)	)	-RRB-
cord-355758-tk7eturq	62	35	.	.	.
cord-355758-tk7eturq	63	1	Of	of	IN
cord-355758-tk7eturq	63	2	and	and	CC
cord-355758-tk7eturq	63	3	RNA	RNA	NNP
cord-355758-tk7eturq	63	4	structure	structure	NN
cord-355758-tk7eturq	63	5	(	(	-LRB-
cord-355758-tk7eturq	63	6	Fig	Fig	NNP
cord-355758-tk7eturq	63	7	4	4	CD
cord-355758-tk7eturq	63	8	and	and	CC
cord-355758-tk7eturq	63	9	5	5	CD
cord-355758-tk7eturq	63	10	)	)	-RRB-
cord-355758-tk7eturq	63	11	.	.	.
cord-355758-tk7eturq	64	1	In	in	IN
cord-355758-tk7eturq	64	2	the	the	DT
cord-355758-tk7eturq	64	3	case	case	NN
cord-355758-tk7eturq	64	4	of	of	IN
cord-355758-tk7eturq	64	5	Nsp4	Nsp4	NNP
cord-355758-tk7eturq	64	6	protein	protein	NN
cord-355758-tk7eturq	64	7	,	,	,
cord-355758-tk7eturq	64	8	two	two	CD
cord-355758-tk7eturq	64	9	nearly	nearly	RB
cord-355758-tk7eturq	64	10	adjacent	adjacent	JJ
cord-355758-tk7eturq	64	11	nonsynonymous	nonsynonymous	JJ
cord-355758-tk7eturq	64	12	substitutions	substitution	NNS
cord-355758-tk7eturq	64	13	at	at	IN
cord-355758-tk7eturq	64	14	residues	residue	NNS
cord-355758-tk7eturq	64	15	380	380	CD
cord-355758-tk7eturq	64	16	430	430	CD
cord-355758-tk7eturq	64	17	and	and	CC
cord-355758-tk7eturq	64	18	382	382	CD
cord-355758-tk7eturq	64	19	occurred	occur	VBD
cord-355758-tk7eturq	64	20	on	on	IN
cord-355758-tk7eturq	64	21	the	the	DT
cord-355758-tk7eturq	64	22	branch	branch	NN
cord-355758-tk7eturq	64	23	leading	lead	VBG
cord-355758-tk7eturq	64	24	to	to	IN
cord-355758-tk7eturq	64	25	SARS	SARS	NNP
cord-355758-tk7eturq	64	26	-	-	HYPH
cord-355758-tk7eturq	64	27	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	64	28	(	(	-LRB-
cord-355758-tk7eturq	64	29	Fig	Fig	NNP
cord-355758-tk7eturq	64	30	3B	3b	CD
cord-355758-tk7eturq	64	31	)	)	-RRB-
cord-355758-tk7eturq	64	32	.	.	.
cord-355758-tk7eturq	65	1	These	these	DT
cord-355758-tk7eturq	65	2	both	both	DT
cord-355758-tk7eturq	65	3	involve	involve	VBP
cord-355758-tk7eturq	65	4	changing	change	VBG
cord-355758-tk7eturq	65	5	431	431	CD
cord-355758-tk7eturq	65	6	side	side	NN
cord-355758-tk7eturq	65	7	chains	chain	NNS
cord-355758-tk7eturq	65	8	with	with	IN
cord-355758-tk7eturq	65	9	similar	similar	JJ
cord-355758-tk7eturq	65	10	biochemical	biochemical	JJ
cord-355758-tk7eturq	65	11	properties	property	NNS
cord-355758-tk7eturq	65	12	,	,	,
cord-355758-tk7eturq	65	13	respectively	respectively	RB
cord-355758-tk7eturq	65	14	valine	valine	NNP
cord-355758-tk7eturq	65	15	to	to	IN
cord-355758-tk7eturq	65	16	alanine	alanine	NN
cord-355758-tk7eturq	65	17	and	and	CC
cord-355758-tk7eturq	65	18	valine	valine	NN
cord-355758-tk7eturq	65	19	to	to	IN
cord-355758-tk7eturq	65	20	432	432	CD
cord-355758-tk7eturq	65	21	isoleucine	isoleucine	NN
cord-355758-tk7eturq	65	22	.	.	.
cord-355758-tk7eturq	66	1	Homology	homology	NN
cord-355758-tk7eturq	66	2	-	-	HYPH
cord-355758-tk7eturq	66	3	directed	direct	VBN
cord-355758-tk7eturq	66	4	modeling	modeling	NN
cord-355758-tk7eturq	66	5	of	of	IN
cord-355758-tk7eturq	66	6	protein	protein	NN
cord-355758-tk7eturq	66	7	structure	structure	NN
cord-355758-tk7eturq	66	8	suggests	suggest	VBZ
cord-355758-tk7eturq	66	9	that	that	IN
cord-355758-tk7eturq	66	10	these	these	DT
cord-355758-tk7eturq	66	11	two	two	CD
cord-355758-tk7eturq	66	12	amino	amino	NNS
cord-355758-tk7eturq	66	13	acid	acid	NN
cord-355758-tk7eturq	66	14	433	433	CD
cord-355758-tk7eturq	66	15	substitutions	substitution	NNS
cord-355758-tk7eturq	66	16	have	have	VBP
cord-355758-tk7eturq	66	17	very	very	RB
cord-355758-tk7eturq	66	18	little	little	JJ
cord-355758-tk7eturq	66	19	impact	impact	NN
cord-355758-tk7eturq	66	20	on	on	IN
cord-355758-tk7eturq	66	21	either	either	DT
cord-355758-tk7eturq	66	22	secondary	secondary	JJ
cord-355758-tk7eturq	66	23	or	or	CC
cord-355758-tk7eturq	66	24	tertiary	tertiary	JJ
cord-355758-tk7eturq	66	25	structure	structure	NN
cord-355758-tk7eturq	66	26	when	when	WRB
cord-355758-tk7eturq	66	27	comparing	compare	VBG
cord-355758-tk7eturq	66	28	the	the	DT
cord-355758-tk7eturq	66	29	434	434	CD
cord-355758-tk7eturq	66	30	SARS	SARS	NNP
cord-355758-tk7eturq	66	31	-	-	HYPH
cord-355758-tk7eturq	66	32	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	66	33	protein	protein	NN
cord-355758-tk7eturq	66	34	orthologue	orthologue	NN
cord-355758-tk7eturq	66	35	to	to	IN
cord-355758-tk7eturq	66	36	those	those	DT
cord-355758-tk7eturq	66	37	of	of	IN
cord-355758-tk7eturq	66	38	the	the	DT
cord-355758-tk7eturq	66	39	other	other	JJ
cord-355758-tk7eturq	66	40	species	specie	NNS
cord-355758-tk7eturq	66	41	examined	examine	VBN
cord-355758-tk7eturq	66	42	(	(	-LRB-
cord-355758-tk7eturq	66	43	Fig	Fig	NNP
cord-355758-tk7eturq	66	44	4A	4a	CD
cord-355758-tk7eturq	66	45	)	)	-RRB-
cord-355758-tk7eturq	66	46	.	.	.
cord-355758-tk7eturq	67	1	In	in	IN
cord-355758-tk7eturq	67	2	the	the	DT
cord-355758-tk7eturq	67	3	case	case	NN
cord-355758-tk7eturq	67	4	of	of	IN
cord-355758-tk7eturq	67	5	435	435	CD
cord-355758-tk7eturq	67	6	Nsp16	Nsp16	NNP
cord-355758-tk7eturq	67	7	protein	protein	NN
cord-355758-tk7eturq	67	8	,	,	,
cord-355758-tk7eturq	67	9	no	no	DT
cord-355758-tk7eturq	67	10	nonsynonymous	nonsynonymous	JJ
cord-355758-tk7eturq	67	11	substitutions	substitution	NNS
cord-355758-tk7eturq	67	12	evolved	evolve	VBN
cord-355758-tk7eturq	67	13	on	on	IN
cord-355758-tk7eturq	67	14	the	the	DT
cord-355758-tk7eturq	67	15	branch	branch	NN
cord-355758-tk7eturq	67	16	leading	lead	VBG
cord-355758-tk7eturq	67	17	to	to	IN
cord-355758-tk7eturq	67	18	SARS	SARS	NNP
cord-355758-tk7eturq	67	19	-	-	HYPH
cord-355758-tk7eturq	67	20	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	67	21	.	.	.
cord-355758-tk7eturq	68	1	Thus	thus	RB
cord-355758-tk7eturq	68	2	,	,	,
cord-355758-tk7eturq	68	3	the	the	DT
cord-355758-tk7eturq	68	4	signal	signal	NN
cord-355758-tk7eturq	68	5	of	of	IN
cord-355758-tk7eturq	68	6	positive	positive	JJ
cord-355758-tk7eturq	68	7	selection	selection	NN
cord-355758-tk7eturq	68	8	within	within	IN
cord-355758-tk7eturq	68	9	Nsp4	Nsp4	NNP
cord-355758-tk7eturq	68	10	is	be	VBZ
cord-355758-tk7eturq	68	11	unlikely	unlikely	JJ
cord-355758-tk7eturq	68	12	to	to	TO
cord-355758-tk7eturq	68	13	reflect	reflect	VB
cord-355758-tk7eturq	68	14	changes	change	NNS
cord-355758-tk7eturq	68	15	in	in	IN
cord-355758-tk7eturq	68	16	protein	protein	NN
cord-355758-tk7eturq	68	17	437	437	CD
cord-355758-tk7eturq	68	18	structure	structure	NN
cord-355758-tk7eturq	68	19	or	or	CC
cord-355758-tk7eturq	68	20	function	function	NN
cord-355758-tk7eturq	68	21	,	,	,
cord-355758-tk7eturq	68	22	while	while	IN
cord-355758-tk7eturq	68	23	the	the	DT
cord-355758-tk7eturq	68	24	signal	signal	NN
cord-355758-tk7eturq	68	25	within	within	IN
cord-355758-tk7eturq	68	26	Nsp16	Nsp16	NNP
cord-355758-tk7eturq	68	27	can	can	MD
cord-355758-tk7eturq	68	28	not	not	RB
cord-355758-tk7eturq	68	29	affect	affect	VB
cord-355758-tk7eturq	68	30	either	either	CC
cord-355758-tk7eturq	68	31	because	because	IN
cord-355758-tk7eturq	68	32	the	the	DT
cord-355758-tk7eturq	68	33	encoded	encoded	JJ
cord-355758-tk7eturq	68	34	438	438	CD
cord-355758-tk7eturq	68	35	polypeptide	polypeptide	NN
cord-355758-tk7eturq	68	36	is	be	VBZ
cord-355758-tk7eturq	68	37	identical	identical	JJ
cord-355758-tk7eturq	68	38	.	.	.
cord-355758-tk7eturq	69	1	With	with	IN
cord-355758-tk7eturq	69	2	highly	highly	RB
cord-355758-tk7eturq	69	3	similar	similar	JJ
cord-355758-tk7eturq	69	4	and	and	CC
cord-355758-tk7eturq	69	5	identical	identical	JJ
cord-355758-tk7eturq	69	6	protein	protein	NN
cord-355758-tk7eturq	69	7	structures	structure	NNS
cord-355758-tk7eturq	69	8	predicted	predict	VBD
cord-355758-tk7eturq	69	9	for	for	IN
cord-355758-tk7eturq	69	10	Nsp4	Nsp4	NNP
cord-355758-tk7eturq	69	11	and	and	CC
cord-355758-tk7eturq	69	12	Nsp16	Nsp16	NNP
cord-355758-tk7eturq	69	13	,	,	,
cord-355758-tk7eturq	69	14	respectively	respectively	RB
cord-355758-tk7eturq	69	15	,	,	,
cord-355758-tk7eturq	69	16	 	 	_SP
cord-355758-tk7eturq	70	1	In	in	IN
cord-355758-tk7eturq	70	2	silico	silico	NN
cord-355758-tk7eturq	70	3	identification	identification	NN
cord-355758-tk7eturq	70	4	of	of	IN
cord-355758-tk7eturq	70	5	conserved	conserved	JJ
cord-355758-tk7eturq	70	6	cis	cis	NNP
cord-355758-tk7eturq	70	7	-acting	-acting	NNP
cord-355758-tk7eturq	70	8	RNA	RNA	NNP
cord-355758-tk7eturq	70	9	elements	element	NNS
cord-355758-tk7eturq	70	10	in	in	IN
cord-355758-tk7eturq	70	11	the	the	DT
cord-355758-tk7eturq	70	12	SARS-493	SARS-493	NNP
cord-355758-tk7eturq	70	13	regulate	regulate	VBP
cord-355758-tk7eturq	70	14	antagonism	antagonism	NN
cord-355758-tk7eturq	70	15	of	of	IN
cord-355758-tk7eturq	70	16	IRF3	IRF3	NNP
cord-355758-tk7eturq	70	17	and	and	CC
cord-355758-tk7eturq	70	18	NF	NF	NNP
cord-355758-tk7eturq	70	19	-	-	HYPH
cord-355758-tk7eturq	70	20	kappaB	kappaB	NNP
cord-355758-tk7eturq	70	21	signaling	signal	VBG
cord-355758-tk7eturq	70	22	Ubiquitination	Ubiquitination	NNP
cord-355758-tk7eturq	70	23	-	-	HYPH
cord-355758-tk7eturq	70	24	mediated	mediate	VBN
cord-355758-tk7eturq	70	25	regulation	regulation	NN
cord-355758-tk7eturq	70	26	of	of	IN
cord-355758-tk7eturq	70	27	interferon	interferon	NN
cord-355758-tk7eturq	70	28	responses	response	NNS
cord-355758-tk7eturq	70	29	Coronavirus	Coronavirus	NNP
cord-355758-tk7eturq	70	30	Spike	Spike	NNP
cord-355758-tk7eturq	70	31	Proteins	protein	NNS
cord-355758-tk7eturq	70	32	in	in	IN
cord-355758-tk7eturq	70	33	Viral	Viral	NNP
cord-355758-tk7eturq	70	34	Entry	Entry	NNP
cord-355758-tk7eturq	70	35	Functional	Functional	NNP
cord-355758-tk7eturq	70	36	RNA	RNA	NNP
cord-355758-tk7eturq	70	37	elements	element	NNS
cord-355758-tk7eturq	70	38	in	in	IN
cord-355758-tk7eturq	70	39	the	the	DT
cord-355758-tk7eturq	70	40	dengue	dengue	NN
cord-355758-tk7eturq	70	41	563	563	CD
cord-355758-tk7eturq	70	42	virus	virus	NN
cord-355758-tk7eturq	70	43	genome	genome	NN
cord-355758-tk7eturq	70	44	Recombination	recombination	NN
cord-355758-tk7eturq	70	45	,	,	,
cord-355758-tk7eturq	70	46	reservoirs	reservoir	NNS
cord-355758-tk7eturq	70	47	,	,	,
cord-355758-tk7eturq	70	48	and	and	CC
cord-355758-tk7eturq	70	49	the	the	DT
cord-355758-tk7eturq	70	50	modular	modular	JJ
cord-355758-tk7eturq	70	51	spike	spike	NN
cord-355758-tk7eturq	70	52	:	:	:
cord-355758-tk7eturq	71	1	mechanisms	mechanism	NNS
cord-355758-tk7eturq	71	2	of	of	IN
cord-355758-tk7eturq	71	3	565	565	CD
cord-355758-tk7eturq	71	4	coronavirus	coronavirus	NN
cord-355758-tk7eturq	71	5	cross	cross	JJ
cord-355758-tk7eturq	71	6	-	-	JJ
cord-355758-tk7eturq	71	7	species	species	JJ
cord-355758-tk7eturq	71	8	transmission	transmission	NN
cord-355758-tk7eturq	72	1	The	the	DT
cord-355758-tk7eturq	72	2	Vienna	Vienna	NNP
cord-355758-tk7eturq	72	3	RNA	RNA	NNP
cord-355758-tk7eturq	72	4	websuite	websuite	NN
cord-355758-tk7eturq	72	5	Membrane	Membrane	NNP
cord-355758-tk7eturq	72	6	571	571	CD
cord-355758-tk7eturq	72	7	rearrangements	rearrangement	NNS
cord-355758-tk7eturq	72	8	mediated	mediate	VBN
cord-355758-tk7eturq	72	9	by	by	IN
cord-355758-tk7eturq	72	10	coronavirus	coronavirus	NN
cord-355758-tk7eturq	72	11	nonstructural	nonstructural	JJ
cord-355758-tk7eturq	72	12	proteins	protein	NNS
cord-355758-tk7eturq	72	13	3	3	CD
cord-355758-tk7eturq	72	14	and	and	CC
cord-355758-tk7eturq	72	15	4	4	CD
cord-355758-tk7eturq	72	16	.	.	.
cord-355758-tk7eturq	73	1	Virology	Virology	NNP
cord-355758-tk7eturq	73	2	Mobility	Mobility	NNP
cord-355758-tk7eturq	73	3	574	574	CD
cord-355758-tk7eturq	73	4	and	and	CC
cord-355758-tk7eturq	73	5	Interactions	Interactions	NNPS
cord-355758-tk7eturq	73	6	of	of	IN
cord-355758-tk7eturq	73	7	Coronavirus	Coronavirus	NNP
cord-355758-tk7eturq	73	8	Nonstructural	Nonstructural	NNP
cord-355758-tk7eturq	73	9	Protein	Protein	NNP
cord-355758-tk7eturq	73	10	4	4	CD
cord-355758-tk7eturq	73	11	Visualizing	visualize	VBG
cord-355758-tk7eturq	73	12	genomic	genomic	JJ
cord-355758-tk7eturq	73	13	data	datum	NNS
cord-355758-tk7eturq	73	14	using	use	VBG
cord-355758-tk7eturq	73	15	Gviz	Gviz	NNP
cord-355758-tk7eturq	73	16	and	and	CC
cord-355758-tk7eturq	73	17	bioconductor	bioconductor	NNP
cord-355758-tk7eturq	73	18	Molecular	Molecular	NNP
cord-355758-tk7eturq	73	19	Biology	Biology	NNP
cord-355758-tk7eturq	73	20	Promoter	Promoter	NNP
cord-355758-tk7eturq	73	21	regions	region	NNS
cord-355758-tk7eturq	73	22	of	of	IN
cord-355758-tk7eturq	73	23	many	many	JJ
cord-355758-tk7eturq	73	24	579	579	CD
cord-355758-tk7eturq	73	25	neural	neural	JJ
cord-355758-tk7eturq	73	26	-	-	HYPH
cord-355758-tk7eturq	73	27	and	and	CC
cord-355758-tk7eturq	73	28	nutrition	nutrition	NN
cord-355758-tk7eturq	73	29	-	-	HYPH
cord-355758-tk7eturq	73	30	related	relate	VBN
cord-355758-tk7eturq	73	31	genes	gene	NNS
cord-355758-tk7eturq	73	32	have	have	VBP
cord-355758-tk7eturq	73	33	experienced	experience	VBN
cord-355758-tk7eturq	73	34	positive	positive	JJ
cord-355758-tk7eturq	73	35	selection	selection	NN
cord-355758-tk7eturq	73	36	during	during	IN
cord-355758-tk7eturq	73	37	human	human	JJ
cord-355758-tk7eturq	73	38	580	580	CD
cord-355758-tk7eturq	73	39	evolution	evolution	NN
cord-355758-tk7eturq	73	40	Temporal	temporal	JJ
cord-355758-tk7eturq	73	41	dynamics	dynamic	NNS
cord-355758-tk7eturq	73	42	in	in	IN
cord-355758-tk7eturq	73	43	viral	viral	JJ
cord-355758-tk7eturq	73	44	shedding	shedding	NN
cord-355758-tk7eturq	73	45	and	and	CC
cord-355758-tk7eturq	73	46	transmissibility	transmissibility	NN
cord-355758-tk7eturq	73	47	of	of	IN
cord-355758-tk7eturq	73	48	584	584	CD
cord-355758-tk7eturq	73	49	COVID-19	COVID-19	NNP
cord-355758-tk7eturq	73	50	Structure	Structure	NNP
cord-355758-tk7eturq	73	51	of	of	IN
cord-355758-tk7eturq	73	52	586	586	CD
cord-355758-tk7eturq	73	53	replicating	replicate	VBG
cord-355758-tk7eturq	73	54	SARS	SARS	NNP
cord-355758-tk7eturq	73	55	-	-	HYPH
cord-355758-tk7eturq	73	56	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	73	57	polymerase	polymerase	NN
cord-355758-tk7eturq	74	1	A	a	DT
cord-355758-tk7eturq	74	2	Multibasic	Multibasic	NNP
cord-355758-tk7eturq	74	3	Cleavage	Cleavage	NNP
cord-355758-tk7eturq	74	4	Site	site	NN
cord-355758-tk7eturq	74	5	in	in	IN
cord-355758-tk7eturq	74	6	the	the	DT
cord-355758-tk7eturq	74	7	Spike	Spike	NNP
cord-355758-tk7eturq	74	8	588	588	CD
cord-355758-tk7eturq	74	9	Protein	Protein	NNP
cord-355758-tk7eturq	74	10	of	of	IN
cord-355758-tk7eturq	74	11	SARS	SARS	NNP
cord-355758-tk7eturq	74	12	-	-	HYPH
cord-355758-tk7eturq	74	13	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	74	14	Is	be	VBZ
cord-355758-tk7eturq	74	15	Essential	essential	JJ
cord-355758-tk7eturq	74	16	for	for	IN
cord-355758-tk7eturq	74	17	Infection	Infection	NNP
cord-355758-tk7eturq	74	18	of	of	IN
cord-355758-tk7eturq	74	19	Human	Human	NNP
cord-355758-tk7eturq	74	20	Lung	Lung	NNP
cord-355758-tk7eturq	74	21	Cells	Cells	NNPS
cord-355758-tk7eturq	74	22	Evidence	evidence	NN
cord-355758-tk7eturq	74	23	of	of	IN
cord-355758-tk7eturq	74	24	the	the	DT
cord-355758-tk7eturq	74	25	Recombinant	Recombinant	NNP
cord-355758-tk7eturq	74	26	Origin	Origin	NNP
cord-355758-tk7eturq	74	27	of	of	IN
cord-355758-tk7eturq	74	28	a	a	DT
cord-355758-tk7eturq	74	29	Bat	Bat	NNP
cord-355758-tk7eturq	74	30	Severe	severe	JJ
cord-355758-tk7eturq	74	31	Acute	acute	JJ
cord-355758-tk7eturq	74	32	Respiratory	respiratory	JJ
cord-355758-tk7eturq	74	33	Syndrome	Syndrome	NNP
cord-355758-tk7eturq	74	34	592	592	CD
cord-355758-tk7eturq	74	35	(	(	-LRB-
cord-355758-tk7eturq	74	36	SARS)-Like	sars)-like	JJ
cord-355758-tk7eturq	74	37	Coronavirus	Coronavirus	NNP
cord-355758-tk7eturq	74	38	and	and	CC
cord-355758-tk7eturq	74	39	Its	-PRON-	PRP$
cord-355758-tk7eturq	74	40	Implications	implication	NNS
cord-355758-tk7eturq	74	41	on	on	IN
cord-355758-tk7eturq	74	42	the	the	DT
cord-355758-tk7eturq	74	43	Direct	Direct	NNP
cord-355758-tk7eturq	74	44	Ancestor	Ancestor	NNP
cord-355758-tk7eturq	74	45	of	of	IN
cord-355758-tk7eturq	74	46	SARS	SARS	NNP
cord-355758-tk7eturq	74	47	Discovery	Discovery	NNP
cord-355758-tk7eturq	74	48	of	of	IN
cord-355758-tk7eturq	74	49	596	596	CD
cord-355758-tk7eturq	74	50	a	a	DT
cord-355758-tk7eturq	74	51	rich	rich	JJ
cord-355758-tk7eturq	74	52	gene	gene	NN
cord-355758-tk7eturq	74	53	pool	pool	NN
cord-355758-tk7eturq	74	54	of	of	IN
cord-355758-tk7eturq	74	55	bat	bat	NN
cord-355758-tk7eturq	74	56	SARS	SARS	NNP
cord-355758-tk7eturq	74	57	-	-	HYPH
cord-355758-tk7eturq	74	58	related	relate	VBN
cord-355758-tk7eturq	74	59	coronaviruses	coronaviruse	NNS
cord-355758-tk7eturq	75	1	provides	provide	VBZ
cord-355758-tk7eturq	75	2	new	new	JJ
cord-355758-tk7eturq	75	3	insights	insight	NNS
cord-355758-tk7eturq	75	4	into	into	IN
cord-355758-tk7eturq	75	5	the	the	DT
cord-355758-tk7eturq	75	6	origin	origin	NN
cord-355758-tk7eturq	75	7	of	of	IN
cord-355758-tk7eturq	75	8	597	597	CD
cord-355758-tk7eturq	75	9	SARS	SARS	NNP
cord-355758-tk7eturq	75	10	coronavirus	coronavirus	NN
cord-355758-tk7eturq	75	11	PHAST	PHAST	NNP
cord-355758-tk7eturq	75	12	and	and	CC
cord-355758-tk7eturq	75	13	RPHAST	RPHAST	NNP
cord-355758-tk7eturq	75	14	:	:	:
cord-355758-tk7eturq	76	1	phylogenetic	phylogenetic	JJ
cord-355758-tk7eturq	76	2	analysis	analysis	NN
cord-355758-tk7eturq	76	3	with	with	IN
cord-355758-tk7eturq	76	4	599	599	CD
cord-355758-tk7eturq	76	5	space	space	NN
cord-355758-tk7eturq	76	6	/	/	SYM
cord-355758-tk7eturq	76	7	time	time	NN
cord-355758-tk7eturq	76	8	models	model	NNS
cord-355758-tk7eturq	76	9	Coronavirus	Coronavirus	NNP
cord-355758-tk7eturq	76	10	Spike	Spike	NNP
cord-355758-tk7eturq	76	11	Protein	Protein	NNP
cord-355758-tk7eturq	76	12	and	and	CC
cord-355758-tk7eturq	76	13	Tropism	tropism	NN
cord-355758-tk7eturq	76	14	Changes	change	VBZ
cord-355758-tk7eturq	76	15	Advances	advance	VBZ
cord-355758-tk7eturq	76	16	in	in	IN
cord-355758-tk7eturq	76	17	Virus	Virus	NNP
cord-355758-tk7eturq	76	18	Research	Research	NNP
cord-355758-tk7eturq	76	19	Comprehensive	Comprehensive	NNP
cord-355758-tk7eturq	76	20	in	in	IN
cord-355758-tk7eturq	76	21	-	-	HYPH
cord-355758-tk7eturq	76	22	vivo	vivo	NN
cord-355758-tk7eturq	76	23	604	604	CD
cord-355758-tk7eturq	76	24	secondary	secondary	JJ
cord-355758-tk7eturq	76	25	structure	structure	NN
cord-355758-tk7eturq	76	26	of	of	IN
cord-355758-tk7eturq	76	27	the	the	DT
cord-355758-tk7eturq	76	28	SARS	SARS	NNP
cord-355758-tk7eturq	76	29	-	-	HYPH
cord-355758-tk7eturq	76	30	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	76	31	genome	genome	NN
cord-355758-tk7eturq	76	32	reveals	reveal	VBZ
cord-355758-tk7eturq	76	33	novel	novel	JJ
cord-355758-tk7eturq	76	34	regulatory	regulatory	JJ
cord-355758-tk7eturq	76	35	motifs	motif	NNS
cord-355758-tk7eturq	76	36	and	and	CC
cord-355758-tk7eturq	76	37	605	605	CD
cord-355758-tk7eturq	76	38	mechanisms	mechanism	NNS
cord-355758-tk7eturq	76	39	.	.	.
cord-355758-tk7eturq	77	1	bioRxiv	biorxiv	RB
cord-355758-tk7eturq	77	2	:	:	:
cord-355758-tk7eturq	77	3	the	the	DT
cord-355758-tk7eturq	77	4	preprint	preprint	NN
cord-355758-tk7eturq	77	5	server	server	NN
cord-355758-tk7eturq	77	6	for	for	IN
cord-355758-tk7eturq	77	7	biology	biology	NN
cord-355758-tk7eturq	78	1	Comprehensive	comprehensive	JJ
cord-355758-tk7eturq	78	2	in	in	IN
cord-355758-tk7eturq	78	3	-	-	HYPH
cord-355758-tk7eturq	78	4	vivo	vivo	NN
cord-355758-tk7eturq	78	5	608	608	CD
cord-355758-tk7eturq	78	6	secondary	secondary	JJ
cord-355758-tk7eturq	78	7	structure	structure	NN
cord-355758-tk7eturq	78	8	of	of	IN
cord-355758-tk7eturq	78	9	the	the	DT
cord-355758-tk7eturq	78	10	SARS	SARS	NNP
cord-355758-tk7eturq	78	11	-	-	HYPH
cord-355758-tk7eturq	78	12	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	78	13	genome	genome	NN
cord-355758-tk7eturq	78	14	reveals	reveal	VBZ
cord-355758-tk7eturq	78	15	novel	novel	JJ
cord-355758-tk7eturq	78	16	regulatory	regulatory	JJ
cord-355758-tk7eturq	78	17	motifs	motif	NNS
cord-355758-tk7eturq	78	18	and	and	CC
cord-355758-tk7eturq	78	19	609	609	CD
cord-355758-tk7eturq	78	20	mechanisms	mechanism	NNS
cord-355758-tk7eturq	78	21	.	.	.
cord-355758-tk7eturq	79	1	bioRxiv	biorxiv	RB
cord-355758-tk7eturq	79	2	:	:	:
cord-355758-tk7eturq	79	3	the	the	DT
cord-355758-tk7eturq	79	4	preprint	preprint	NN
cord-355758-tk7eturq	79	5	server	server	NN
cord-355758-tk7eturq	79	6	for	for	IN
cord-355758-tk7eturq	79	7	biology	biology	NN
cord-355758-tk7eturq	80	1	MAFFT	MAFFT	NNP
cord-355758-tk7eturq	80	2	Multiple	Multiple	NNP
cord-355758-tk7eturq	80	3	Sequence	Sequence	NNP
cord-355758-tk7eturq	80	4	Alignment	Alignment	NNP
cord-355758-tk7eturq	80	5	Software	Software	NNP
cord-355758-tk7eturq	80	6	Version	Version	NNP
cord-355758-tk7eturq	80	7	7	7	CD
cord-355758-tk7eturq	80	8	:	:	:
cord-355758-tk7eturq	81	1	612	612	CD
cord-355758-tk7eturq	81	2	Improvements	improvement	NNS
cord-355758-tk7eturq	81	3	in	in	IN
cord-355758-tk7eturq	81	4	Performance	Performance	NNP
cord-355758-tk7eturq	81	5	and	and	CC
cord-355758-tk7eturq	81	6	Usability	Usability	NNP
cord-355758-tk7eturq	81	7	Geneious	Geneious	NNP
cord-355758-tk7eturq	82	1	616	616	CD
cord-355758-tk7eturq	82	2	Basic	basic	JJ
cord-355758-tk7eturq	82	3	:	:	:
cord-355758-tk7eturq	82	4	an	an	DT
cord-355758-tk7eturq	82	5	integrated	integrated	JJ
cord-355758-tk7eturq	82	6	and	and	CC
cord-355758-tk7eturq	82	7	extendable	extendable	JJ
cord-355758-tk7eturq	82	8	desktop	desktop	NN
cord-355758-tk7eturq	82	9	software	software	NN
cord-355758-tk7eturq	82	10	platform	platform	NN
cord-355758-tk7eturq	82	11	for	for	IN
cord-355758-tk7eturq	82	12	the	the	DT
cord-355758-tk7eturq	82	13	organization	organization	NN
cord-355758-tk7eturq	82	14	and	and	CC
cord-355758-tk7eturq	82	15	617	617	CD
cord-355758-tk7eturq	82	16	analysis	analysis	NN
cord-355758-tk7eturq	82	17	of	of	IN
cord-355758-tk7eturq	82	18	sequence	sequence	NN
cord-355758-tk7eturq	82	19	data	datum	NNS
cord-355758-tk7eturq	83	1	The	the	DT
cord-355758-tk7eturq	83	2	Phyre2	Phyre2	NNP
cord-355758-tk7eturq	83	3	web	web	NN
cord-355758-tk7eturq	83	4	portal	portal	NN
cord-355758-tk7eturq	83	5	for	for	IN
cord-355758-tk7eturq	83	6	620	620	CD
cord-355758-tk7eturq	83	7	protein	protein	NN
cord-355758-tk7eturq	83	8	modeling	modeling	NN
cord-355758-tk7eturq	83	9	,	,	,
cord-355758-tk7eturq	83	10	prediction	prediction	NN
cord-355758-tk7eturq	83	11	and	and	CC
cord-355758-tk7eturq	83	12	analysis	analysis	NN
cord-355758-tk7eturq	84	1	The	the	DT
cord-355758-tk7eturq	84	2	Architecture	Architecture	NNP
cord-355758-tk7eturq	84	3	of	of	IN
cord-355758-tk7eturq	84	4	SARS	SARS	NNP
cord-355758-tk7eturq	84	5	-	-	HYPH
cord-355758-tk7eturq	84	6	CoV-623	CoV-623	NNP
cord-355758-tk7eturq	85	1	Tracking	track	VBG
cord-355758-tk7eturq	85	2	628	628	CD
cord-355758-tk7eturq	85	3	Changes	change	NNS
cord-355758-tk7eturq	85	4	in	in	IN
cord-355758-tk7eturq	85	5	SARS	SARS	NNP
cord-355758-tk7eturq	85	6	-	-	HYPH
cord-355758-tk7eturq	85	7	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	85	8	Spike	spike	NN
cord-355758-tk7eturq	85	9	:	:	:
cord-355758-tk7eturq	85	10	Evidence	evidence	NN
cord-355758-tk7eturq	85	11	that	that	IN
cord-355758-tk7eturq	85	12	D614	d614	NN
cord-355758-tk7eturq	85	13	G	g	NN
cord-355758-tk7eturq	85	14	Increases	Increases	NNPS
cord-355758-tk7eturq	85	15	Infectivity	infectivity	NN
cord-355758-tk7eturq	85	16	of	of	IN
cord-355758-tk7eturq	85	17	the	the	DT
cord-355758-tk7eturq	85	18	COVID-629	COVID-629	NNP
cord-355758-tk7eturq	85	19	RAxML	RAxML	NNP
cord-355758-tk7eturq	85	20	-	-	HYPH
cord-355758-tk7eturq	85	21	NG	NG	NNP
cord-355758-tk7eturq	85	22	:	:	:
cord-355758-tk7eturq	85	23	A	a	DT
cord-355758-tk7eturq	85	24	fast	fast	JJ
cord-355758-tk7eturq	85	25	,	,	,
cord-355758-tk7eturq	85	26	631	631	CD
cord-355758-tk7eturq	85	27	scalable	scalable	JJ
cord-355758-tk7eturq	85	28	and	and	CC
cord-355758-tk7eturq	85	29	user	user	NN
cord-355758-tk7eturq	85	30	-	-	HYPH
cord-355758-tk7eturq	85	31	friendly	friendly	JJ
cord-355758-tk7eturq	85	32	tool	tool	NN
cord-355758-tk7eturq	85	33	for	for	IN
cord-355758-tk7eturq	85	34	maximum	maximum	JJ
cord-355758-tk7eturq	85	35	likelihood	likelihood	NN
cord-355758-tk7eturq	85	36	phylogenetic	phylogenetic	JJ
cord-355758-tk7eturq	85	37	inference	inference	NN
cord-355758-tk7eturq	85	38	Identifying	identify	VBG
cord-355758-tk7eturq	85	39	SARS	SARS	NNP
cord-355758-tk7eturq	85	40	-	-	HYPH
cord-355758-tk7eturq	85	41	CoV-2-related	cov-2-relate	VBN
cord-355758-tk7eturq	85	42	coronaviruses	coronaviruse	NNS
cord-355758-tk7eturq	85	43	in	in	IN
cord-355758-tk7eturq	85	44	Malayan	Malayan	NNP
cord-355758-tk7eturq	85	45	637	637	CD
cord-355758-tk7eturq	85	46	pangolins	pangolin	NNS
cord-355758-tk7eturq	86	1	Severe	severe	JJ
cord-355758-tk7eturq	86	2	Acute	acute	JJ
cord-355758-tk7eturq	86	3	Respiratory	Respiratory	NNP
cord-355758-tk7eturq	86	4	Syndrome	Syndrome	NNP
cord-355758-tk7eturq	86	5	(	(	-LRB-
cord-355758-tk7eturq	86	6	SARS	SARS	NNP
cord-355758-tk7eturq	86	7	)	)	-RRB-
cord-355758-tk7eturq	86	8	Horseshoe	Horseshoe	NNP
cord-355758-tk7eturq	86	9	Bats	Bats	NNPS
cord-355758-tk7eturq	86	10	through	through	IN
cord-355758-tk7eturq	86	11	Recombination	Recombination	NNP
cord-355758-tk7eturq	86	12	Emergence	Emergence	NNP
cord-355758-tk7eturq	86	13	of	of	IN
cord-355758-tk7eturq	86	14	SARS	SARS	NNP
cord-355758-tk7eturq	86	15	-	-	HYPH
cord-355758-tk7eturq	86	16	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	86	17	through	through	IN
cord-355758-tk7eturq	86	18	recombination	recombination	NN
cord-355758-tk7eturq	86	19	and	and	CC
cord-355758-tk7eturq	86	20	strong	strong	JJ
cord-355758-tk7eturq	86	21	646	646	CD
cord-355758-tk7eturq	86	22	purifying	purifying	NN
cord-355758-tk7eturq	86	23	selection	selection	NN
cord-355758-tk7eturq	87	1	The	the	DT
cord-355758-tk7eturq	87	2	divergence	divergence	NN
cord-355758-tk7eturq	87	3	between	between	IN
cord-355758-tk7eturq	87	4	SARS	SARS	NNP
cord-355758-tk7eturq	87	5	-	-	HYPH
cord-355758-tk7eturq	87	6	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	87	7	and	and	CC
cord-355758-tk7eturq	87	8	RaTG13	RaTG13	NNP
cord-355758-tk7eturq	87	9	might	may	MD
cord-355758-tk7eturq	87	10	be	be	VB
cord-355758-tk7eturq	87	11	overestimated	overestimate	VBN
cord-355758-tk7eturq	87	12	due	due	IN
cord-355758-tk7eturq	87	13	to	to	IN
cord-355758-tk7eturq	87	14	the	the	DT
cord-355758-tk7eturq	87	15	extensive	extensive	JJ
cord-355758-tk7eturq	87	16	RNA	RNA	NNP
cord-355758-tk7eturq	87	17	modification	modification	NN
cord-355758-tk7eturq	87	18	Viral	Viral	NNP
cord-355758-tk7eturq	87	19	Metagenomics	Metagenomics	NNPS
cord-355758-tk7eturq	87	20	Revealed	reveal	VBD
cord-355758-tk7eturq	87	21	Sendai	Sendai	NNP
cord-355758-tk7eturq	87	22	Virus	Virus	NNP
cord-355758-tk7eturq	87	23	and	and	CC
cord-355758-tk7eturq	87	24	Coronavirus	Coronavirus	NNP
cord-355758-tk7eturq	87	25	651	651	CD
cord-355758-tk7eturq	87	26	Infection	Infection	NNP
cord-355758-tk7eturq	87	27	of	of	IN
cord-355758-tk7eturq	87	28	Malayan	malayan	JJ
cord-355758-tk7eturq	87	29	Pangolins	Pangolins	NNPS
cord-355758-tk7eturq	87	30	(	(	-LRB-
cord-355758-tk7eturq	87	31	Manis	Manis	NNP
cord-355758-tk7eturq	87	32	javanica	javanica	NNS
cord-355758-tk7eturq	87	33	)	)	-RRB-
cord-355758-tk7eturq	87	34	ViennaRNA	ViennaRNA	.
cord-355758-tk7eturq	88	1	Package	package	NN
cord-355758-tk7eturq	88	2	2.0	2.0	CD
cord-355758-tk7eturq	88	3	Severe	severe	JJ
cord-355758-tk7eturq	88	4	acute	acute	JJ
cord-355758-tk7eturq	88	5	respiratory	respiratory	JJ
cord-355758-tk7eturq	88	6	syndrome	syndrome	NN
cord-355758-tk7eturq	88	7	-	-	HYPH
cord-355758-tk7eturq	88	8	associated	associate	VBN
cord-355758-tk7eturq	88	9	coronavirus	coronavirus	NN
cord-355758-tk7eturq	88	10	3a	3a	CD
cord-355758-tk7eturq	88	11	protein	protein	NN
cord-355758-tk7eturq	88	12	forms	form	VBZ
cord-355758-tk7eturq	88	13	an	an	DT
cord-355758-tk7eturq	88	14	ion	ion	NN
cord-355758-tk7eturq	88	15	658	658	CD
cord-355758-tk7eturq	88	16	channel	channel	NN
cord-355758-tk7eturq	88	17	and	and	CC
cord-355758-tk7eturq	88	18	modulates	modulate	VBZ
cord-355758-tk7eturq	88	19	virus	virus	NN
cord-355758-tk7eturq	88	20	release	release	NN
cord-355758-tk7eturq	88	21	Cleavage	Cleavage	NNP
cord-355758-tk7eturq	88	22	Inhibition	Inhibition	NNP
cord-355758-tk7eturq	88	23	of	of	IN
cord-355758-tk7eturq	88	24	661	661	CD
cord-355758-tk7eturq	88	25	the	the	DT
cord-355758-tk7eturq	88	26	Murine	Murine	NNP
cord-355758-tk7eturq	88	27	Coronavirus	Coronavirus	NNP
cord-355758-tk7eturq	88	28	Spike	Spike	NNP
cord-355758-tk7eturq	88	29	Protein	Protein	NNP
cord-355758-tk7eturq	88	30	by	by	IN
cord-355758-tk7eturq	88	31	a	a	DT
cord-355758-tk7eturq	88	32	Furin	Furin	NNP
cord-355758-tk7eturq	88	33	-	-	HYPH
cord-355758-tk7eturq	88	34	Like	Like	NNP
cord-355758-tk7eturq	88	35	Enzyme	Enzyme	NNS
cord-355758-tk7eturq	89	1	Affects	affect	VBZ
cord-355758-tk7eturq	89	2	Cell	cell	NN
cord-355758-tk7eturq	89	3	-	-	HYPH
cord-355758-tk7eturq	89	4	Cell	cell	NN
cord-355758-tk7eturq	89	5	but	but	CC
cord-355758-tk7eturq	89	6	Not	not	RB
cord-355758-tk7eturq	89	7	662	662	CD
cord-355758-tk7eturq	89	8	Virus	virus	NN
cord-355758-tk7eturq	89	9	-	-	HYPH
cord-355758-tk7eturq	89	10	Cell	Cell	NNP
cord-355758-tk7eturq	89	11	Fusion	Fusion	NNP
cord-355758-tk7eturq	89	12	Downloaded	download	VBN
cord-355758-tk7eturq	89	13	from	from	IN
cord-355758-tk7eturq	89	14	Mechanism	Mechanism	NNP
cord-355758-tk7eturq	89	15	and	and	CC
cord-355758-tk7eturq	89	16	structural	structural	JJ
cord-355758-tk7eturq	89	17	diversity	diversity	NN
cord-355758-tk7eturq	89	18	of	of	IN
cord-355758-tk7eturq	89	19	exoribonuclease-666	exoribonuclease-666	JJ
cord-355758-tk7eturq	89	20	resistant	resistant	JJ
cord-355758-tk7eturq	89	21	RNA	RNA	NNP
cord-355758-tk7eturq	89	22	structures	structure	NNS
cord-355758-tk7eturq	89	23	in	in	IN
cord-355758-tk7eturq	89	24	flaviviral	flaviviral	NNP
cord-355758-tk7eturq	89	25	RNAs	rna	NNS
cord-355758-tk7eturq	90	1	Coronavirus	Coronavirus	NNP
cord-355758-tk7eturq	90	2	cis	cis	NNP
cord-355758-tk7eturq	90	3	-	-	HYPH
cord-355758-tk7eturq	90	4	Acting	Acting	NNP
cord-355758-tk7eturq	90	5	RNA	RNA	NNP
cord-355758-tk7eturq	90	6	Elements	Elements	NNPS
cord-355758-tk7eturq	91	1	The	the	DT
cord-355758-tk7eturq	91	2	SARS	SARS	NNP
cord-355758-tk7eturq	91	3	coronavirus	coronavirus	NN
cord-355758-tk7eturq	91	4	papain	papain	NN
cord-355758-tk7eturq	91	5	like	like	IN
cord-355758-tk7eturq	91	6	protease	protease	NN
cord-355758-tk7eturq	91	7	672	672	CD
cord-355758-tk7eturq	91	8	can	can	MD
cord-355758-tk7eturq	91	9	inhibit	inhibit	VB
cord-355758-tk7eturq	91	10	IRF3	IRF3	NNP
cord-355758-tk7eturq	91	11	at	at	IN
cord-355758-tk7eturq	91	12	a	a	DT
cord-355758-tk7eturq	91	13	post	post	JJ
cord-355758-tk7eturq	91	14	activation	activation	NN
cord-355758-tk7eturq	91	15	step	step	NN
cord-355758-tk7eturq	91	16	that	that	WDT
cord-355758-tk7eturq	91	17	requires	require	VBZ
cord-355758-tk7eturq	91	18	deubiquitination	deubiquitination	NN
cord-355758-tk7eturq	91	19	activity	activity	NN
cord-355758-tk7eturq	91	20	Coronavirus	Coronavirus	NNP
cord-355758-tk7eturq	91	21	non	non	JJ
cord-355758-tk7eturq	91	22	-	-	JJ
cord-355758-tk7eturq	91	23	structural	structural	JJ
cord-355758-tk7eturq	91	24	protein	protein	NN
cord-355758-tk7eturq	91	25	16	16	CD
cord-355758-tk7eturq	91	26	:	:	:
cord-355758-tk7eturq	91	27	Evasion	evasion	NN
cord-355758-tk7eturq	91	28	,	,	,
cord-355758-tk7eturq	91	29	675	675	CD
cord-355758-tk7eturq	91	30	attenuation	attenuation	NN
cord-355758-tk7eturq	91	31	,	,	,
cord-355758-tk7eturq	91	32	and	and	CC
cord-355758-tk7eturq	91	33	possible	possible	JJ
cord-355758-tk7eturq	91	34	treatments	treatment	NNS
cord-355758-tk7eturq	92	1	The	the	DT
cord-355758-tk7eturq	92	2	SARS	SARS	NNP
cord-355758-tk7eturq	92	3	Coronavirus	Coronavirus	NNP
cord-355758-tk7eturq	92	4	3a	3a	CD
cord-355758-tk7eturq	92	5	678	678	CD
cord-355758-tk7eturq	93	1	protein	protein	NN
cord-355758-tk7eturq	93	2	causes	cause	VBZ
cord-355758-tk7eturq	93	3	endoplasmic	endoplasmic	NN
cord-355758-tk7eturq	93	4	reticulum	reticulum	NN
cord-355758-tk7eturq	93	5	stress	stress	NN
cord-355758-tk7eturq	93	6	and	and	CC
cord-355758-tk7eturq	93	7	induces	induce	VBZ
cord-355758-tk7eturq	93	8	ligand	ligand	NN
cord-355758-tk7eturq	93	9	-	-	HYPH
cord-355758-tk7eturq	93	10	independent	independent	JJ
cord-355758-tk7eturq	93	11	679	679	CD
cord-355758-tk7eturq	93	12	downregulation	downregulation	NN
cord-355758-tk7eturq	93	13	of	of	IN
cord-355758-tk7eturq	93	14	the	the	DT
cord-355758-tk7eturq	93	15	type	type	NN
cord-355758-tk7eturq	93	16	1	1	CD
cord-355758-tk7eturq	93	17	interferon	interferon	NN
cord-355758-tk7eturq	93	18	receptor	receptor	NN
cord-355758-tk7eturq	93	19	Viral	Viral	NNP
cord-355758-tk7eturq	93	20	innate	innate	JJ
cord-355758-tk7eturq	93	21	immune	immune	JJ
cord-355758-tk7eturq	93	22	evasion	evasion	NN
cord-355758-tk7eturq	93	23	and	and	CC
cord-355758-tk7eturq	93	24	the	the	DT
cord-355758-tk7eturq	93	25	pathogenesis	pathogenesis	NN
cord-355758-tk7eturq	93	26	of	of	IN
cord-355758-tk7eturq	93	27	emerging	emerge	VBG
cord-355758-tk7eturq	93	28	682	682	CD
cord-355758-tk7eturq	93	29	RNA	RNA	NNP
cord-355758-tk7eturq	93	30	virus	virus	NN
cord-355758-tk7eturq	93	31	infections	infection	NNS
cord-355758-tk7eturq	94	1	The	the	DT
cord-355758-tk7eturq	94	2	ratio	ratio	NN
cord-355758-tk7eturq	94	3	of	of	IN
cord-355758-tk7eturq	94	4	replacement	replacement	NN
cord-355758-tk7eturq	94	5	to	to	IN
cord-355758-tk7eturq	94	6	silent	silent	JJ
cord-355758-tk7eturq	94	7	divergence	divergence	NN
cord-355758-tk7eturq	94	8	and	and	CC
cord-355758-tk7eturq	94	9	tests	test	NNS
cord-355758-tk7eturq	94	10	of	of	IN
cord-355758-tk7eturq	94	11	neutrality	neutrality	NN
cord-355758-tk7eturq	94	12	Topology	topology	NN
cord-355758-tk7eturq	94	13	and	and	CC
cord-355758-tk7eturq	94	14	Membrane	Membrane	NNP
cord-355758-tk7eturq	94	15	Anchoring	Anchoring	NNP
cord-355758-tk7eturq	94	16	of	of	IN
cord-355758-tk7eturq	94	17	the	the	DT
cord-355758-tk7eturq	94	18	Coronavirus	Coronavirus	NNP
cord-355758-tk7eturq	94	19	Replication	Replication	NNP
cord-355758-tk7eturq	94	20	Complex	Complex	NNP
cord-355758-tk7eturq	94	21	:	:	:
cord-355758-tk7eturq	94	22	687	687	CD
cord-355758-tk7eturq	95	1	Not	not	RB
cord-355758-tk7eturq	95	2	All	all	DT
cord-355758-tk7eturq	95	3	Hydrophobic	Hydrophobic	NNP
cord-355758-tk7eturq	95	4	Domains	domain	NNS
cord-355758-tk7eturq	95	5	of	of	IN
cord-355758-tk7eturq	95	6	nsp3	nsp3	NNS
cord-355758-tk7eturq	95	7	and	and	CC
cord-355758-tk7eturq	95	8	nsp6	nsp6	NN
cord-355758-tk7eturq	95	9	Are	be	VBP
cord-355758-tk7eturq	96	1	Membrane	membrane	NN
cord-355758-tk7eturq	96	2	Spanning	Spanning	NNP
cord-355758-tk7eturq	96	3	Emerging	Emerging	NNP
cord-355758-tk7eturq	96	4	SARS	SARS	NNP
cord-355758-tk7eturq	96	5	-	-	HYPH
cord-355758-tk7eturq	96	6	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	96	7	mutation	mutation	NN
cord-355758-tk7eturq	96	8	hot	hot	JJ
cord-355758-tk7eturq	96	9	691	691	CD
cord-355758-tk7eturq	96	10	spots	spot	NNS
cord-355758-tk7eturq	96	11	include	include	VBP
cord-355758-tk7eturq	96	12	a	a	DT
cord-355758-tk7eturq	96	13	novel	novel	JJ
cord-355758-tk7eturq	96	14	RNA	rna	NN
cord-355758-tk7eturq	96	15	-	-	HYPH
cord-355758-tk7eturq	96	16	dependent	dependent	JJ
cord-355758-tk7eturq	96	17	-	-	HYPH
cord-355758-tk7eturq	96	18	RNA	rna	NN
cord-355758-tk7eturq	96	19	polymerase	polymerase	NN
cord-355758-tk7eturq	96	20	variant	variant	NN
cord-355758-tk7eturq	96	21	Structure	structure	NN
cord-355758-tk7eturq	96	22	of	of	IN
cord-355758-tk7eturq	96	23	the	the	DT
cord-355758-tk7eturq	96	24	human	human	JJ
cord-355758-tk7eturq	96	25	metapneumovirus	metapneumovirus	NN
cord-355758-tk7eturq	96	26	polymerase	polymerase	NNP
cord-355758-tk7eturq	96	27	695	695	CD
cord-355758-tk7eturq	96	28	phosphoprotein	phosphoprotein	NN
cord-355758-tk7eturq	96	29	complex	complex	JJ
cord-355758-tk7eturq	96	30	Clinical	clinical	JJ
cord-355758-tk7eturq	96	31	progression	progression	NN
cord-355758-tk7eturq	96	32	and	and	CC
cord-355758-tk7eturq	96	33	viral	viral	JJ
cord-355758-tk7eturq	96	34	load	load	NN
cord-355758-tk7eturq	96	35	in	in	IN
cord-355758-tk7eturq	96	36	a	a	DT
cord-355758-tk7eturq	96	37	community	community	NN
cord-355758-tk7eturq	96	38	outbreak	outbreak	NN
cord-355758-tk7eturq	96	39	of	of	IN
cord-355758-tk7eturq	96	40	coronavirus-699	coronavirus-699	NN
cord-355758-tk7eturq	97	1	associated	associated	NNP
cord-355758-tk7eturq	97	2	SARS	SARS	NNP
cord-355758-tk7eturq	97	3	pneumonia	pneumonia	NN
cord-355758-tk7eturq	97	4	:	:	:
cord-355758-tk7eturq	98	1	A	a	DT
cord-355758-tk7eturq	98	2	prospective	prospective	JJ
cord-355758-tk7eturq	98	3	study	study	NN
cord-355758-tk7eturq	99	1	The	the	DT
cord-355758-tk7eturq	99	2	Coding	Coding	NNP
cord-355758-tk7eturq	99	3	Region	Region	NNP
cord-355758-tk7eturq	99	4	of	of	IN
cord-355758-tk7eturq	99	5	the	the	DT
cord-355758-tk7eturq	99	6	HCV	HCV	NNP
cord-355758-tk7eturq	99	7	702	702	NNP
cord-355758-tk7eturq	99	8	Genome	Genome	NNP
cord-355758-tk7eturq	99	9	Contains	contain	VBZ
cord-355758-tk7eturq	99	10	a	a	DT
cord-355758-tk7eturq	99	11	Network	Network	NNP
cord-355758-tk7eturq	99	12	of	of	IN
cord-355758-tk7eturq	99	13	Regulatory	Regulatory	NNP
cord-355758-tk7eturq	99	14	RNA	RNA	NNP
cord-355758-tk7eturq	99	15	Structures	Structures	NNPS
cord-355758-tk7eturq	99	16	Estimating	estimate	VBG
cord-355758-tk7eturq	99	17	variability	variability	NN
cord-355758-tk7eturq	99	18	in	in	IN
cord-355758-tk7eturq	99	19	the	the	DT
cord-355758-tk7eturq	99	20	transmission	transmission	NN
cord-355758-tk7eturq	99	21	of	of	IN
cord-355758-tk7eturq	99	22	severe	severe	JJ
cord-355758-tk7eturq	99	23	705	705	CD
cord-355758-tk7eturq	99	24	acute	acute	JJ
cord-355758-tk7eturq	99	25	respiratory	respiratory	JJ
cord-355758-tk7eturq	99	26	syndrome	syndrome	NN
cord-355758-tk7eturq	99	27	to	to	IN
cord-355758-tk7eturq	99	28	household	household	NN
cord-355758-tk7eturq	99	29	contacts	contact	NNS
cord-355758-tk7eturq	99	30	in	in	IN
cord-355758-tk7eturq	99	31	Hong	Hong	NNP
cord-355758-tk7eturq	99	32	Kong	Kong	NNP
cord-355758-tk7eturq	99	33	HyPhy	HyPhy	NNP
cord-355758-tk7eturq	99	34	:	:	:
cord-355758-tk7eturq	99	35	hypothesis	hypothesis	NN
cord-355758-tk7eturq	99	36	testing	testing	NN
cord-355758-tk7eturq	99	37	using	use	VBG
cord-355758-tk7eturq	99	38	phylogenies	phylogeny	NNS
cord-355758-tk7eturq	99	39	HyPhy	HyPhy	NNP
cord-355758-tk7eturq	99	40	711	711	CD
cord-355758-tk7eturq	99	41	2.5-A	2.5-a	CD
cord-355758-tk7eturq	99	42	Customizable	Customizable	NNP
cord-355758-tk7eturq	99	43	Platform	Platform	NNP
cord-355758-tk7eturq	99	44	for	for	IN
cord-355758-tk7eturq	99	45	Evolutionary	Evolutionary	NNP
cord-355758-tk7eturq	99	46	Hypothesis	Hypothesis	NNP
cord-355758-tk7eturq	99	47	Testing	Testing	NNP
cord-355758-tk7eturq	99	48	Using	use	VBG
cord-355758-tk7eturq	99	49	Phylogenies	Phylogenies	NNP
cord-355758-tk7eturq	99	50	RNA	RNA	NNP
cord-355758-tk7eturq	99	51	genome	genome	NN
cord-355758-tk7eturq	99	52	conservation	conservation	NN
cord-355758-tk7eturq	99	53	and	and	CC
cord-355758-tk7eturq	99	54	secondary	secondary	JJ
cord-355758-tk7eturq	99	55	structure	structure	NN
cord-355758-tk7eturq	99	56	in	in	IN
cord-355758-tk7eturq	99	57	SARS	SARS	NNP
cord-355758-tk7eturq	99	58	-	-	HYPH
cord-355758-tk7eturq	99	59	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	99	60	and	and	CC
cord-355758-tk7eturq	99	61	SARS	SARS	NNP
cord-355758-tk7eturq	99	62	-	-	HYPH
cord-355758-tk7eturq	99	63	related	relate	VBN
cord-355758-tk7eturq	99	64	715	715	CD
cord-355758-tk7eturq	99	65	viruses	virus	NNS
cord-355758-tk7eturq	99	66	:	:	:
cord-355758-tk7eturq	100	1	a	a	DT
cord-355758-tk7eturq	100	2	first	first	JJ
cord-355758-tk7eturq	100	3	look	look	NN
cord-355758-tk7eturq	100	4	Comparative	comparative	JJ
cord-355758-tk7eturq	100	5	analysis	analysis	NN
cord-355758-tk7eturq	100	6	of	of	IN
cord-355758-tk7eturq	100	7	coronavirus	coronavirus	NN
cord-355758-tk7eturq	100	8	genomic	genomic	JJ
cord-355758-tk7eturq	100	9	RNA	RNA	NNP
cord-355758-tk7eturq	100	10	structure	structure	NN
cord-355758-tk7eturq	100	11	reveals	reveal	VBZ
cord-355758-tk7eturq	100	12	718	718	CD
cord-355758-tk7eturq	100	13	conservation	conservation	NN
cord-355758-tk7eturq	100	14	in	in	IN
cord-355758-tk7eturq	100	15	SARS	SARS	NNP
cord-355758-tk7eturq	100	16	-	-	HYPH
cord-355758-tk7eturq	100	17	like	like	JJ
cord-355758-tk7eturq	100	18	coronaviruses	coronaviruse	NNS
cord-355758-tk7eturq	100	19	.	.	.
cord-355758-tk7eturq	101	1	bioRxiv	biorxiv	RB
cord-355758-tk7eturq	101	2	:	:	:
cord-355758-tk7eturq	101	3	the	the	DT
cord-355758-tk7eturq	101	4	preprint	preprint	NN
cord-355758-tk7eturq	101	5	server	server	NN
cord-355758-tk7eturq	101	6	for	for	IN
cord-355758-tk7eturq	101	7	biology	biology	NN
cord-355758-tk7eturq	102	1	In	in	IN
cord-355758-tk7eturq	102	2	search	search	NN
cord-355758-tk7eturq	102	3	of	of	IN
cord-355758-tk7eturq	102	4	molecular	molecular	JJ
cord-355758-tk7eturq	102	5	darwinism	darwinism	NN
cord-355758-tk7eturq	102	6	Evolutionarily	evolutionarily	RB
cord-355758-tk7eturq	102	7	conserved	conserve	VBN
cord-355758-tk7eturq	102	8	elements	element	NNS
cord-355758-tk7eturq	102	9	in	in	IN
cord-355758-tk7eturq	102	10	vertebrate	vertebrate	NN
cord-355758-tk7eturq	102	11	,	,	,
cord-355758-tk7eturq	102	12	insect	insect	NN
cord-355758-tk7eturq	102	13	,	,	,
cord-355758-tk7eturq	102	14	worm	worm	NN
cord-355758-tk7eturq	102	15	,	,	,
cord-355758-tk7eturq	102	16	and	and	CC
cord-355758-tk7eturq	102	17	yeast	yeast	NN
cord-355758-tk7eturq	102	18	725	725	CD
cord-355758-tk7eturq	102	19	genomes	genome	NNS
cord-355758-tk7eturq	102	20	The	the	DT
cord-355758-tk7eturq	102	21	Nonstructural	nonstructural	JJ
cord-355758-tk7eturq	102	22	Proteins	protein	NNS
cord-355758-tk7eturq	102	23	Directing	direct	VBG
cord-355758-tk7eturq	102	24	Coronavirus	Coronavirus	NNP
cord-355758-tk7eturq	102	25	RNA	RNA	NNP
cord-355758-tk7eturq	102	26	727	727	CD
cord-355758-tk7eturq	102	27	Synthesis	Synthesis	NNP
cord-355758-tk7eturq	102	28	and	and	CC
cord-355758-tk7eturq	102	29	Processing	Processing	NNP
cord-355758-tk7eturq	102	30	The	the	DT
cord-355758-tk7eturq	102	31	Severe	severe	JJ
cord-355758-tk7eturq	102	32	Acute	acute	JJ
cord-355758-tk7eturq	102	33	Respiratory	Respiratory	NNP
cord-355758-tk7eturq	102	34	Syndrome	Syndrome	NNP
cord-355758-tk7eturq	102	35	Coronavirus	Coronavirus	NNP
cord-355758-tk7eturq	102	36	3a	3a	NN
cord-355758-tk7eturq	102	37	Protein	Protein	NNP
cord-355758-tk7eturq	102	38	Up	Up	NNP
cord-355758-tk7eturq	102	39	-	-	HYPH
cord-355758-tk7eturq	102	40	Regulates	regulate	VBZ
cord-355758-tk7eturq	102	41	Expression	expression	NN
cord-355758-tk7eturq	102	42	of	of	IN
cord-355758-tk7eturq	102	43	Fibrinogen	Fibrinogen	NNP
cord-355758-tk7eturq	102	44	in	in	IN
cord-355758-tk7eturq	102	45	Lung	Lung	NNP
cord-355758-tk7eturq	102	46	Epithelial	epithelial	NN
cord-355758-tk7eturq	102	47	Cells	cell	NNS
cord-355758-tk7eturq	102	48	On	on	IN
cord-355758-tk7eturq	102	49	the	the	DT
cord-355758-tk7eturq	102	50	origin	origin	NN
cord-355758-tk7eturq	102	51	and	and	CC
cord-355758-tk7eturq	102	52	continuing	continue	VBG
cord-355758-tk7eturq	102	53	evolution	evolution	NN
cord-355758-tk7eturq	102	54	of	of	IN
cord-355758-tk7eturq	102	55	SARS	SARS	NNP
cord-355758-tk7eturq	102	56	-	-	HYPH
cord-355758-tk7eturq	102	57	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	102	58	Structural	structural	JJ
cord-355758-tk7eturq	102	59	insights	insight	NNS
cord-355758-tk7eturq	102	60	into	into	IN
cord-355758-tk7eturq	102	61	coronavirus	coronavirus	NN
cord-355758-tk7eturq	102	62	entry	entry	NN
cord-355758-tk7eturq	102	63	SARS	SARS	NNP
cord-355758-tk7eturq	102	64	-	-	HYPH
cord-355758-tk7eturq	102	65	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	102	66	genomic	genomic	JJ
cord-355758-tk7eturq	102	67	739	739	CD
cord-355758-tk7eturq	102	68	variations	variation	NNS
cord-355758-tk7eturq	102	69	associated	associate	VBN
cord-355758-tk7eturq	102	70	with	with	IN
cord-355758-tk7eturq	102	71	mortality	mortality	NN
cord-355758-tk7eturq	102	72	rate	rate	NN
cord-355758-tk7eturq	102	73	of	of	IN
cord-355758-tk7eturq	102	74	COVID-19	COVID-19	NNP
cord-355758-tk7eturq	102	75	Inhibition	Inhibition	NNP
cord-355758-tk7eturq	102	76	of	of	IN
cord-355758-tk7eturq	102	77	IRF3-dependent	IRF3-dependent	NNP
cord-355758-tk7eturq	102	78	antiviral	antiviral	JJ
cord-355758-tk7eturq	102	79	responses	response	NNS
cord-355758-tk7eturq	102	80	by	by	IN
cord-355758-tk7eturq	102	81	742	742	CD
cord-355758-tk7eturq	102	82	cellular	cellular	JJ
cord-355758-tk7eturq	102	83	and	and	CC
cord-355758-tk7eturq	102	84	viral	viral	JJ
cord-355758-tk7eturq	102	85	proteins	protein	NNS
cord-355758-tk7eturq	102	86	Positive	positive	VBP
cord-355758-tk7eturq	102	87	744	744	CD
cord-355758-tk7eturq	102	88	selection	selection	NN
cord-355758-tk7eturq	102	89	of	of	IN
cord-355758-tk7eturq	102	90	ORF3a	ORF3a	NNP
cord-355758-tk7eturq	102	91	and	and	CC
cord-355758-tk7eturq	102	92	ORF8	orf8	JJ
cord-355758-tk7eturq	102	93	genes	gene	NNS
cord-355758-tk7eturq	102	94	drives	drive	VBZ
cord-355758-tk7eturq	102	95	the	the	DT
cord-355758-tk7eturq	102	96	evolution	evolution	NN
cord-355758-tk7eturq	102	97	of	of	IN
cord-355758-tk7eturq	102	98	SARS	SARS	NNP
cord-355758-tk7eturq	102	99	-	-	:
cord-355758-tk7eturq	102	100	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	102	101	during	during	IN
cord-355758-tk7eturq	102	102	the	the	DT
cord-355758-tk7eturq	102	103	2020	2020	CD
cord-355758-tk7eturq	102	104	Enhanced	enhanced	JJ
cord-355758-tk7eturq	102	105	receptor	receptor	NN
cord-355758-tk7eturq	102	106	binding	binding	NN
cord-355758-tk7eturq	102	107	of	of	IN
cord-355758-tk7eturq	102	108	SARS	SARS	NNP
cord-355758-tk7eturq	102	109	-	-	HYPH
cord-355758-tk7eturq	102	110	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	102	111	through	through	IN
cord-355758-tk7eturq	102	112	networks	network	NNS
cord-355758-tk7eturq	102	113	of	of	IN
cord-355758-tk7eturq	102	114	747	747	CD
cord-355758-tk7eturq	102	115	hydrogen	hydrogen	NN
cord-355758-tk7eturq	102	116	-	-	HYPH
cord-355758-tk7eturq	102	117	bonding	bonding	NN
cord-355758-tk7eturq	102	118	and	and	CC
cord-355758-tk7eturq	102	119	hydrophobic	hydrophobic	JJ
cord-355758-tk7eturq	102	120	interactions	interaction	NNS
cord-355758-tk7eturq	102	121	Structural	structural	JJ
cord-355758-tk7eturq	102	122	and	and	CC
cord-355758-tk7eturq	102	123	Functional	Functional	NNP
cord-355758-tk7eturq	102	124	Basis	Basis	NNP
cord-355758-tk7eturq	102	125	of	of	IN
cord-355758-tk7eturq	102	126	SARS	SARS	NNP
cord-355758-tk7eturq	102	127	-	-	HYPH
cord-355758-tk7eturq	102	128	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	102	129	Entry	Entry	NNP
cord-355758-tk7eturq	102	130	by	by	IN
cord-355758-tk7eturq	102	131	Using	use	VBG
cord-355758-tk7eturq	102	132	752	752	CD
cord-355758-tk7eturq	102	133	Exploitation	exploitation	NN
cord-355758-tk7eturq	102	134	of	of	IN
cord-355758-tk7eturq	102	135	glycosylation	glycosylation	NN
cord-355758-tk7eturq	102	136	in	in	IN
cord-355758-tk7eturq	102	137	754	754	CD
cord-355758-tk7eturq	102	138	enveloped	envelop	VBD
cord-355758-tk7eturq	102	139	virus	virus	NN
cord-355758-tk7eturq	102	140	pathobiology	pathobiology	NN
cord-355758-tk7eturq	102	141	Detecting	detect	VBG
cord-355758-tk7eturq	102	142	selection	selection	NN
cord-355758-tk7eturq	102	143	in	in	IN
cord-355758-tk7eturq	102	144	noncoding	noncoding	JJ
cord-355758-tk7eturq	102	145	regions	region	NNS
cord-355758-tk7eturq	102	146	of	of	IN
cord-355758-tk7eturq	102	147	nucleotide	nucleotide	JJ
cord-355758-tk7eturq	102	148	757	757	CD
cord-355758-tk7eturq	102	149	sequences	sequence	NNS
cord-355758-tk7eturq	102	150	Cryo	Cryo	NNP
cord-355758-tk7eturq	102	151	-	-	HYPH
cord-355758-tk7eturq	102	152	EM	EM	NNP
cord-355758-tk7eturq	102	153	structure	structure	NN
cord-355758-tk7eturq	102	154	of	of	IN
cord-355758-tk7eturq	102	155	the	the	DT
cord-355758-tk7eturq	102	156	2019-nCoV	2019-ncov	CD
cord-355758-tk7eturq	102	157	spike	spike	NN
cord-355758-tk7eturq	102	158	in	in	IN
cord-355758-tk7eturq	102	159	the	the	DT
cord-355758-tk7eturq	102	160	prefusion	prefusion	NN
cord-355758-tk7eturq	102	161	conformation	conformation	NN
cord-355758-tk7eturq	102	162	Cryo	Cryo	NNP
cord-355758-tk7eturq	102	163	-	-	HYPH
cord-355758-tk7eturq	102	164	EM	EM	NNP
cord-355758-tk7eturq	102	165	analysis	analysis	NN
cord-355758-tk7eturq	102	166	of	of	IN
cord-355758-tk7eturq	102	167	a	a	DT
cord-355758-tk7eturq	102	168	feline	feline	JJ
cord-355758-tk7eturq	102	169	coronavirus	coronavirus	NN
cord-355758-tk7eturq	102	170	spike	spike	NN
cord-355758-tk7eturq	102	171	protein	protein	NN
cord-355758-tk7eturq	102	172	763	763	CD
cord-355758-tk7eturq	103	1	reveals	reveal	VBZ
cord-355758-tk7eturq	103	2	a	a	DT
cord-355758-tk7eturq	103	3	unique	unique	JJ
cord-355758-tk7eturq	103	4	structure	structure	NN
cord-355758-tk7eturq	103	5	and	and	CC
cord-355758-tk7eturq	103	6	camouflaging	camouflage	VBG
cord-355758-tk7eturq	103	7	glycans	glycan	NNS
cord-355758-tk7eturq	103	8	Mutation	mutation	NN
cord-355758-tk7eturq	103	9	-	-	HYPH
cord-355758-tk7eturq	103	10	selection	selection	NN
cord-355758-tk7eturq	103	11	models	model	NNS
cord-355758-tk7eturq	103	12	of	of	IN
cord-355758-tk7eturq	103	13	codon	codon	NN
cord-355758-tk7eturq	103	14	substitution	substitution	NN
cord-355758-tk7eturq	103	15	and	and	CC
cord-355758-tk7eturq	103	16	their	-PRON-	PRP$
cord-355758-tk7eturq	103	17	use	use	NN
cord-355758-tk7eturq	103	18	to	to	IN
cord-355758-tk7eturq	103	19	766	766	CD
cord-355758-tk7eturq	103	20	estimate	estimate	NN
cord-355758-tk7eturq	103	21	selective	selective	JJ
cord-355758-tk7eturq	103	22	strengths	strength	NNS
cord-355758-tk7eturq	103	23	on	on	IN
cord-355758-tk7eturq	103	24	codon	codon	NN
cord-355758-tk7eturq	103	25	usage	usage	NN
cord-355758-tk7eturq	103	26	FATCAT	FATCAT	NNP
cord-355758-tk7eturq	103	27	:	:	:
cord-355758-tk7eturq	104	1	a	a	DT
cord-355758-tk7eturq	104	2	web	web	NN
cord-355758-tk7eturq	104	3	server	server	NN
cord-355758-tk7eturq	104	4	for	for	IN
cord-355758-tk7eturq	104	5	flexible	flexible	JJ
cord-355758-tk7eturq	104	6	structure	structure	NN
cord-355758-tk7eturq	104	7	comparison	comparison	NN
cord-355758-tk7eturq	104	8	and	and	CC
cord-355758-tk7eturq	104	9	structure	structure	NN
cord-355758-tk7eturq	104	10	769	769	CD
cord-355758-tk7eturq	104	11	similarity	similarity	NN
cord-355758-tk7eturq	104	12	searching	search	VBG
cord-355758-tk7eturq	104	13	Coronavirus	Coronavirus	NNP
cord-355758-tk7eturq	104	14	Open	Open	NNP
cord-355758-tk7eturq	104	15	Reading	Reading	NNP
cord-355758-tk7eturq	104	16	Frame-3a	Frame-3a	NNP
cord-355758-tk7eturq	104	17	drives	drive	VBZ
cord-355758-tk7eturq	104	18	multimodal	multimodal	JJ
cord-355758-tk7eturq	104	19	necrotic	necrotic	JJ
cord-355758-tk7eturq	104	20	cell	cell	NN
cord-355758-tk7eturq	104	21	death	death	NN
cord-355758-tk7eturq	105	1	The	the	DT
cord-355758-tk7eturq	105	2	short-774	short-774	NN
cord-355758-tk7eturq	105	3	and	and	CC
cord-355758-tk7eturq	105	4	long	long	JJ
cord-355758-tk7eturq	105	5	-	-	HYPH
cord-355758-tk7eturq	105	6	range	range	NN
cord-355758-tk7eturq	105	7	RNA	RNA	NNP
cord-355758-tk7eturq	105	8	-	-	HYPH
cord-355758-tk7eturq	105	9	RNA	RNA	NNP
cord-355758-tk7eturq	105	10	Interactome	Interactome	NNP
cord-355758-tk7eturq	105	11	of	of	IN
cord-355758-tk7eturq	105	12	SARS	SARS	NNP
cord-355758-tk7eturq	105	13	-	-	HYPH
cord-355758-tk7eturq	105	14	CoV-2	CoV-2	NNP
cord-355758-tk7eturq	106	1	Co	Co	NNS
cord-355758-tk7eturq	106	2	-	-	JJ
cord-355758-tk7eturq	106	3	first	first	JJ
cord-355758-tk7eturq	106	4	authors	author	NNS
cord-355758-tk7eturq	106	5	Ribose	Ribose	NNP
cord-355758-tk7eturq	106	6	2'-O-778	2'-o-778	CD
cord-355758-tk7eturq	106	7	methylation	methylation	NN
cord-355758-tk7eturq	106	8	provides	provide	VBZ
cord-355758-tk7eturq	106	9	a	a	DT
cord-355758-tk7eturq	106	10	molecular	molecular	JJ
cord-355758-tk7eturq	106	11	signature	signature	NN
cord-355758-tk7eturq	106	12	for	for	IN
cord-355758-tk7eturq	106	13	the	the	DT
cord-355758-tk7eturq	106	14	distinction	distinction	NN
cord-355758-tk7eturq	106	15	of	of	IN
cord-355758-tk7eturq	106	16	self	self	NN
cord-355758-tk7eturq	106	17	and	and	CC
cord-355758-tk7eturq	106	18	non	non	JJ
cord-355758-tk7eturq	106	19	-	-	JJ
cord-355758-tk7eturq	106	20	self	self	JJ
cord-355758-tk7eturq	106	21	mRNA	mrna	NN
cord-355758-tk7eturq	106	22	779	779	CD
cord-355758-tk7eturq	106	23	dependent	dependent	JJ
cord-355758-tk7eturq	106	24	on	on	IN
cord-355758-tk7eturq	106	25	the	the	DT
cord-355758-tk7eturq	106	26	RNA	RNA	NNP
cord-355758-tk7eturq	106	27	sensor	sensor	NN
cord-355758-tk7eturq	106	28	Mda5	Mda5	NNP