id	sid	tid	token	lemma	pos
cord-349417-vn7q8wc4	1	1	key	key	NN
cord-349417-vn7q8wc4	1	2	:	:	:
cord-349417-vn7q8wc4	2	1	cord-349417-vn7q8wc4	cord-349417-vn7q8wc4	CD
cord-349417-vn7q8wc4	2	2	authors	author	NNS
cord-349417-vn7q8wc4	2	3	:	:	:
cord-349417-vn7q8wc4	2	4	Ziebuhr	Ziebuhr	NNP
cord-349417-vn7q8wc4	2	5	,	,	,
cord-349417-vn7q8wc4	2	6	John	John	NNP
cord-349417-vn7q8wc4	2	7	title	title	NN
cord-349417-vn7q8wc4	2	8	:	:	:
cord-349417-vn7q8wc4	2	9	The	the	DT
cord-349417-vn7q8wc4	2	10	Coronavirus	Coronavirus	NNP
cord-349417-vn7q8wc4	2	11	Replicase	replicase	NN
cord-349417-vn7q8wc4	2	12	:	:	:
cord-349417-vn7q8wc4	2	13	Insights	insight	NNS
cord-349417-vn7q8wc4	2	14	into	into	IN
cord-349417-vn7q8wc4	2	15	a	a	DT
cord-349417-vn7q8wc4	2	16	Sophisticated	Sophisticated	NNP
cord-349417-vn7q8wc4	2	17	Enzyme	Enzyme	NNP
cord-349417-vn7q8wc4	2	18	Machinery	Machinery	NNP
cord-349417-vn7q8wc4	2	19	date	date	NN
cord-349417-vn7q8wc4	2	20	:	:	:
cord-349417-vn7q8wc4	3	1	2006	2006	CD
cord-349417-vn7q8wc4	3	2	journal	journal	NNP
cord-349417-vn7q8wc4	3	3	:	:	:
cord-349417-vn7q8wc4	4	1	The	the	DT
cord-349417-vn7q8wc4	4	2	Nidoviruses	Nidoviruses	NNP
cord-349417-vn7q8wc4	4	3	DOI	DOI	NNP
cord-349417-vn7q8wc4	4	4	:	:	:
cord-349417-vn7q8wc4	4	5	10.1007/978	10.1007/978	CD
cord-349417-vn7q8wc4	4	6	-	-	HYPH
cord-349417-vn7q8wc4	4	7	0	0	CD
cord-349417-vn7q8wc4	4	8	-	-	HYPH
cord-349417-vn7q8wc4	4	9	387	387	CD
cord-349417-vn7q8wc4	4	10	-	-	HYPH
cord-349417-vn7q8wc4	4	11	33012	33012	CD
cord-349417-vn7q8wc4	4	12	-	-	SYM
cord-349417-vn7q8wc4	4	13	9_1	9_1	CD
cord-349417-vn7q8wc4	4	14	sha	sha	NNP
cord-349417-vn7q8wc4	4	15	:	:	:
cord-349417-vn7q8wc4	4	16	aaf20d5bad4bac46ffd8baaa84e6fdf54b66072c	aaf20d5bad4bac46ffd8baaa84e6fdf54b66072c	NNP
cord-349417-vn7q8wc4	4	17	doc_id	doc_id	NNP
cord-349417-vn7q8wc4	4	18	:	:	:
cord-349417-vn7q8wc4	4	19	349417	349417	CD
cord-349417-vn7q8wc4	4	20	cord_uid	cord_uid	NNS
cord-349417-vn7q8wc4	4	21	:	:	:
cord-349417-vn7q8wc4	5	1	vn7q8wc4	vn7q8wc4	NNP
cord-349417-vn7q8wc4	5	2	nan	nan	NNP
cord-349417-vn7q8wc4	5	3	gene	gene	NN
cord-349417-vn7q8wc4	5	4	-	-	HYPH
cord-349417-vn7q8wc4	5	5	encoded	encode	VBN
cord-349417-vn7q8wc4	5	6	proteins	protein	NNS
cord-349417-vn7q8wc4	5	7	,	,	,
cord-349417-vn7q8wc4	5	8	includes	include	VBZ
cord-349417-vn7q8wc4	5	9	several	several	JJ
cord-349417-vn7q8wc4	5	10	cellular	cellular	JJ
cord-349417-vn7q8wc4	5	11	proteins	protein	NNS
cord-349417-vn7q8wc4	5	12	and	and	CC
cord-349417-vn7q8wc4	5	13	the	the	DT
cord-349417-vn7q8wc4	5	14	viral	viral	JJ
cord-349417-vn7q8wc4	5	15	nucleocapsid	nucleocapsid	NNP
cord-349417-vn7q8wc4	5	16	protein	protein	NN
cord-349417-vn7q8wc4	5	17	.	.	.
cord-349417-vn7q8wc4	6	1	[	[	-LRB-
cord-349417-vn7q8wc4	6	2	11	11	CD
cord-349417-vn7q8wc4	6	3	]	]	-RRB-
cord-349417-vn7q8wc4	6	4	[	[	-LRB-
cord-349417-vn7q8wc4	6	5	12	12	CD
cord-349417-vn7q8wc4	6	6	]	]	-RRB-
cord-349417-vn7q8wc4	6	7	[	[	-LRB-
cord-349417-vn7q8wc4	6	8	13	13	CD
cord-349417-vn7q8wc4	6	9	]	]	-RRB-
cord-349417-vn7q8wc4	6	10	14	14	CD
cord-349417-vn7q8wc4	6	11	)	)	-RRB-
cord-349417-vn7q8wc4	6	12	.	.	.
cord-349417-vn7q8wc4	7	1	Translation	translation	NN
cord-349417-vn7q8wc4	7	2	of	of	IN
cord-349417-vn7q8wc4	7	3	the	the	DT
cord-349417-vn7q8wc4	7	4	genomic	genomic	JJ
cord-349417-vn7q8wc4	7	5	RNA	RNA	NNP
cord-349417-vn7q8wc4	7	6	gives	give	VBZ
cord-349417-vn7q8wc4	7	7	rise	rise	NN
cord-349417-vn7q8wc4	7	8	to	to	IN
cord-349417-vn7q8wc4	7	9	two	two	CD
cord-349417-vn7q8wc4	7	10	replicative	replicative	JJ
cord-349417-vn7q8wc4	7	11	polyproteins	polyprotein	NNS
cord-349417-vn7q8wc4	7	12	,	,	,
cord-349417-vn7q8wc4	7	13	pp1a	pp1a	NNP
cord-349417-vn7q8wc4	7	14	and	and	CC
cord-349417-vn7q8wc4	7	15	pp1ab	pp1ab	NNP
cord-349417-vn7q8wc4	7	16	,	,	,
cord-349417-vn7q8wc4	7	17	that	that	WDT
cord-349417-vn7q8wc4	7	18	mediate	mediate	VBP
cord-349417-vn7q8wc4	7	19	the	the	DT
cord-349417-vn7q8wc4	7	20	key	key	JJ
cord-349417-vn7q8wc4	7	21	functions	function	NNS
cord-349417-vn7q8wc4	7	22	required	require	VBN
cord-349417-vn7q8wc4	7	23	for	for	IN
cord-349417-vn7q8wc4	7	24	SARS	SARS	NNP
cord-349417-vn7q8wc4	7	25	-	-	HYPH
cord-349417-vn7q8wc4	7	26	CoV	CoV	NNP
cord-349417-vn7q8wc4	7	27	genome	genome	NN
cord-349417-vn7q8wc4	7	28	replication	replication	NN
cord-349417-vn7q8wc4	7	29	and	and	CC
cord-349417-vn7q8wc4	7	30	synthesis	synthesis	NN
cord-349417-vn7q8wc4	7	31	of	of	IN
cord-349417-vn7q8wc4	7	32	8	8	CD
cord-349417-vn7q8wc4	7	33	major	major	JJ
cord-349417-vn7q8wc4	7	34	subgenomic	subgenomic	JJ
cord-349417-vn7q8wc4	7	35	RNAs	rna	NNS
cord-349417-vn7q8wc4	7	36	encoding	encode	VBG
cord-349417-vn7q8wc4	7	37	the	the	DT
cord-349417-vn7q8wc4	7	38	structural	structural	JJ
cord-349417-vn7q8wc4	7	39	proteins	protein	NNS
cord-349417-vn7q8wc4	7	40	(	(	-LRB-
cord-349417-vn7q8wc4	7	41	shown	show	VBN
cord-349417-vn7q8wc4	7	42	in	in	IN
cord-349417-vn7q8wc4	7	43	black	black	JJ
cord-349417-vn7q8wc4	7	44	)	)	-RRB-
cord-349417-vn7q8wc4	7	45	and	and	CC
cord-349417-vn7q8wc4	7	46	several	several	JJ
cord-349417-vn7q8wc4	7	47	SARS	SARS	NNP
cord-349417-vn7q8wc4	7	48	-	-	HYPH
cord-349417-vn7q8wc4	7	49	CoV	cov	NN
cord-349417-vn7q8wc4	7	50	-	-	HYPH
cord-349417-vn7q8wc4	7	51	specific	specific	JJ
cord-349417-vn7q8wc4	7	52	accessory	accessory	NN
cord-349417-vn7q8wc4	7	53	proteins	protein	NNS
cord-349417-vn7q8wc4	7	54	.	.	.
cord-349417-vn7q8wc4	8	1	Expression	expression	NN
cord-349417-vn7q8wc4	8	2	of	of	IN
cord-349417-vn7q8wc4	8	3	ORF1b	ORF1b	NNP
cord-349417-vn7q8wc4	8	4	sequences	sequence	NNS
cord-349417-vn7q8wc4	8	5	requires	require	VBZ
cord-349417-vn7q8wc4	8	6	a	a	DT
cord-349417-vn7q8wc4	8	7	programmed	program	VBN
cord-349417-vn7q8wc4	8	8	ribosomal	ribosomal	JJ
cord-349417-vn7q8wc4	8	9	frameshift	frameshift	NN
cord-349417-vn7q8wc4	8	10	into	into	IN
cord-349417-vn7q8wc4	8	11	the	the	DT
cord-349417-vn7q8wc4	8	12	-1	-1	NN
cord-349417-vn7q8wc4	8	13	reading	reading	NN
cord-349417-vn7q8wc4	8	14	frame	frame	NN
cord-349417-vn7q8wc4	8	15	during	during	IN
cord-349417-vn7q8wc4	8	16	translation	translation	NN
cord-349417-vn7q8wc4	8	17	of	of	IN
cord-349417-vn7q8wc4	8	18	the	the	DT
cord-349417-vn7q8wc4	8	19	genome	genome	NN
cord-349417-vn7q8wc4	8	20	RNA	RNA	NNP
cord-349417-vn7q8wc4	8	21	,	,	,
cord-349417-vn7q8wc4	8	22	which	which	WDT
cord-349417-vn7q8wc4	8	23	occurs	occur	VBZ
cord-349417-vn7q8wc4	8	24	just	just	RB
cord-349417-vn7q8wc4	8	25	upstream	upstream	RB
cord-349417-vn7q8wc4	8	26	of	of	IN
cord-349417-vn7q8wc4	8	27	the	the	DT
cord-349417-vn7q8wc4	8	28	ORF1a	ORF1a	NNP
cord-349417-vn7q8wc4	8	29	translation	translation	NN
cord-349417-vn7q8wc4	8	30	stop	stop	VB
cord-349417-vn7q8wc4	8	31	codon	codon	NNP
cord-349417-vn7q8wc4	8	32	.	.	.
cord-349417-vn7q8wc4	9	1	The	the	DT
cord-349417-vn7q8wc4	9	2	replicative	replicative	JJ
cord-349417-vn7q8wc4	9	3	polyproteins	polyprotein	NNS
cord-349417-vn7q8wc4	9	4	are	be	VBP
cord-349417-vn7q8wc4	9	5	extensively	extensively	RB
cord-349417-vn7q8wc4	9	6	processed	process	VBN
cord-349417-vn7q8wc4	9	7	by	by	IN
cord-349417-vn7q8wc4	9	8	viral	viral	JJ
cord-349417-vn7q8wc4	9	9	proteases	protease	NNS
cord-349417-vn7q8wc4	9	10	.	.	.
cord-349417-vn7q8wc4	10	1	The	the	DT
cord-349417-vn7q8wc4	10	2	processing	processing	NN
cord-349417-vn7q8wc4	10	3	end	end	NN
cord-349417-vn7q8wc4	10	4	-	-	HYPH
cord-349417-vn7q8wc4	10	5	products	product	NNS
cord-349417-vn7q8wc4	10	6	of	of	IN
cord-349417-vn7q8wc4	10	7	pp1a	pp1a	NNP
cord-349417-vn7q8wc4	10	8	are	be	VBP
cord-349417-vn7q8wc4	10	9	designated	designate	VBN
cord-349417-vn7q8wc4	10	10	nonstructural	nonstructural	JJ
cord-349417-vn7q8wc4	10	11	proteins	protein	NNS
cord-349417-vn7q8wc4	10	12	(	(	-LRB-
cord-349417-vn7q8wc4	10	13	nsp	nsp	NN
cord-349417-vn7q8wc4	10	14	)	)	-RRB-
cord-349417-vn7q8wc4	10	15	1	1	CD
cord-349417-vn7q8wc4	10	16	to	to	IN
cord-349417-vn7q8wc4	10	17	nsp11	nsp11	ADD
cord-349417-vn7q8wc4	11	1	and	and	CC
cord-349417-vn7q8wc4	11	2	those	those	DT
cord-349417-vn7q8wc4	11	3	of	of	IN
cord-349417-vn7q8wc4	11	4	pp1ab	pp1ab	NNP
cord-349417-vn7q8wc4	11	5	are	be	VBP
cord-349417-vn7q8wc4	11	6	designated	designate	VBN
cord-349417-vn7q8wc4	11	7	nsp1	nsp1	NNS
cord-349417-vn7q8wc4	11	8	to	to	IN
cord-349417-vn7q8wc4	11	9	nsp10	nsp10	NNP
cord-349417-vn7q8wc4	11	10	and	and	CC
cord-349417-vn7q8wc4	11	11	nsp12	nsp12	NNS
cord-349417-vn7q8wc4	11	12	to	to	IN
cord-349417-vn7q8wc4	11	13	nsp16	nsp16	NNS
cord-349417-vn7q8wc4	11	14	.	.	.
cord-349417-vn7q8wc4	12	1	Cleavage	cleavage	NN
cord-349417-vn7q8wc4	12	2	sites	site	NNS
cord-349417-vn7q8wc4	12	3	that	that	WDT
cord-349417-vn7q8wc4	12	4	are	be	VBP
cord-349417-vn7q8wc4	12	5	processed	process	VBN
cord-349417-vn7q8wc4	12	6	by	by	IN
cord-349417-vn7q8wc4	12	7	the	the	DT
cord-349417-vn7q8wc4	12	8	3C	3c	NN
cord-349417-vn7q8wc4	12	9	-	-	HYPH
cord-349417-vn7q8wc4	12	10	like	like	JJ
cord-349417-vn7q8wc4	12	11	protease	protease	NN
cord-349417-vn7q8wc4	12	12	(	(	-LRB-
cord-349417-vn7q8wc4	12	13	3CL	3CL	NNP
cord-349417-vn7q8wc4	12	14	pro	pro	NNP
cord-349417-vn7q8wc4	12	15	)	)	-RRB-
cord-349417-vn7q8wc4	12	16	,	,	,
cord-349417-vn7q8wc4	12	17	which	which	WDT
cord-349417-vn7q8wc4	12	18	is	be	VBZ
cord-349417-vn7q8wc4	12	19	also	also	RB
cord-349417-vn7q8wc4	12	20	called	call	VBN
cord-349417-vn7q8wc4	12	21	main	main	JJ
cord-349417-vn7q8wc4	12	22	protease	protease	NN
cord-349417-vn7q8wc4	12	23	(	(	-LRB-
cord-349417-vn7q8wc4	12	24	M	M	NNP
cord-349417-vn7q8wc4	12	25	pro	pro	FW
cord-349417-vn7q8wc4	12	26	)	)	-RRB-
cord-349417-vn7q8wc4	12	27	,	,	,
cord-349417-vn7q8wc4	12	28	are	be	VBP
cord-349417-vn7q8wc4	12	29	indicated	indicate	VBN
cord-349417-vn7q8wc4	12	30	by	by	IN
cord-349417-vn7q8wc4	12	31	gray	gray	JJ
cord-349417-vn7q8wc4	12	32	arrowheads	arrowhead	NNS
cord-349417-vn7q8wc4	12	33	,	,	,
cord-349417-vn7q8wc4	12	34	and	and	CC
cord-349417-vn7q8wc4	12	35	sites	site	NNS
cord-349417-vn7q8wc4	12	36	that	that	WDT
cord-349417-vn7q8wc4	12	37	are	be	VBP
cord-349417-vn7q8wc4	12	38	processed	process	VBN
cord-349417-vn7q8wc4	12	39	by	by	IN
cord-349417-vn7q8wc4	12	40	the	the	DT
cord-349417-vn7q8wc4	12	41	papain	papain	NN
cord-349417-vn7q8wc4	12	42	-	-	HYPH
cord-349417-vn7q8wc4	12	43	like	like	JJ
cord-349417-vn7q8wc4	12	44	protease	protease	NN
cord-349417-vn7q8wc4	12	45	,	,	,
cord-349417-vn7q8wc4	12	46	PL2	PL2	NNP
cord-349417-vn7q8wc4	12	47	pro	pro	NNP
cord-349417-vn7q8wc4	12	48	,	,	,
cord-349417-vn7q8wc4	12	49	are	be	VBP
cord-349417-vn7q8wc4	12	50	indicated	indicate	VBN
cord-349417-vn7q8wc4	12	51	by	by	IN
cord-349417-vn7q8wc4	12	52	black	black	JJ
cord-349417-vn7q8wc4	12	53	arrowheads	arrowhead	NNS
cord-349417-vn7q8wc4	12	54	.	.	.
cord-349417-vn7q8wc4	13	1	The	the	DT
cord-349417-vn7q8wc4	13	2	major	major	JJ
cord-349417-vn7q8wc4	13	3	replicative	replicative	JJ
cord-349417-vn7q8wc4	13	4	domains	domain	NNS
cord-349417-vn7q8wc4	13	5	are	be	VBP
cord-349417-vn7q8wc4	13	6	shown	show	VBN
cord-349417-vn7q8wc4	13	7	in	in	IN
cord-349417-vn7q8wc4	13	8	dark	dark	JJ
cord-349417-vn7q8wc4	13	9	gray	gray	NN
cord-349417-vn7q8wc4	13	10	and	and	CC
cord-349417-vn7q8wc4	13	11	transmembrane	transmembrane	JJ
cord-349417-vn7q8wc4	13	12	domains	domain	NNS
cord-349417-vn7q8wc4	13	13	predicted	predict	VBN
cord-349417-vn7q8wc4	13	14	to	to	TO
cord-349417-vn7q8wc4	13	15	anchor	anchor	VB
cord-349417-vn7q8wc4	13	16	the	the	DT
cord-349417-vn7q8wc4	13	17	viral	viral	JJ
cord-349417-vn7q8wc4	13	18	replicase	replicase	NN
cord-349417-vn7q8wc4	13	19	to	to	IN
cord-349417-vn7q8wc4	13	20	intracellular	intracellular	JJ
cord-349417-vn7q8wc4	13	21	membranes	membrane	NNS
cord-349417-vn7q8wc4	13	22	are	be	VBP
cord-349417-vn7q8wc4	13	23	indicated	indicate	VBN
cord-349417-vn7q8wc4	13	24	in	in	IN
cord-349417-vn7q8wc4	13	25	light	light	JJ
cord-349417-vn7q8wc4	13	26	gray	gray	JJ
cord-349417-vn7q8wc4	13	27	.	.	.
cord-349417-vn7q8wc4	14	1	Appr-1"-pase	Appr-1"-pase	NNP
cord-349417-vn7q8wc4	14	2	,	,	,
cord-349417-vn7q8wc4	14	3	ADP	ADP	NNP
cord-349417-vn7q8wc4	14	4	-	-	HYPH
cord-349417-vn7q8wc4	14	5	ribose	ribose	NN
cord-349417-vn7q8wc4	14	6	1"-phosphatase	1"-phosphatase	CD
cord-349417-vn7q8wc4	14	7	;	;	:
cord-349417-vn7q8wc4	14	8	PL2	PL2	NNP
cord-349417-vn7q8wc4	14	9	pro	pro	NNP
cord-349417-vn7q8wc4	14	10	,	,	,
cord-349417-vn7q8wc4	14	11	papain	papain	NN
cord-349417-vn7q8wc4	14	12	-	-	HYPH
cord-349417-vn7q8wc4	14	13	like	like	JJ
cord-349417-vn7q8wc4	14	14	cysteine	cysteine	NN
cord-349417-vn7q8wc4	14	15	protease	protease	NN
cord-349417-vn7q8wc4	14	16	2	2	CD
cord-349417-vn7q8wc4	14	17	;	;	:
cord-349417-vn7q8wc4	14	18	3CL	3CL	NNP
cord-349417-vn7q8wc4	14	19	pro	pro	NNP
cord-349417-vn7q8wc4	14	20	,	,	,
cord-349417-vn7q8wc4	14	21	3C	3c	NN
cord-349417-vn7q8wc4	14	22	-	-	HYPH
cord-349417-vn7q8wc4	14	23	like	like	JJ
cord-349417-vn7q8wc4	14	24	main	main	JJ
cord-349417-vn7q8wc4	14	25	protease	protease	NN
cord-349417-vn7q8wc4	14	26	;	;	:
cord-349417-vn7q8wc4	14	27	RdRp	RdRp	NNP
cord-349417-vn7q8wc4	14	28	,	,	,
cord-349417-vn7q8wc4	14	29	RNA	RNA	NNP
cord-349417-vn7q8wc4	14	30	-	-	HYPH
cord-349417-vn7q8wc4	14	31	dependent	dependent	JJ
cord-349417-vn7q8wc4	14	32	RNA	RNA	NNP
cord-349417-vn7q8wc4	14	33	polymerase	polymerase	NN
cord-349417-vn7q8wc4	14	34	;	;	:
cord-349417-vn7q8wc4	14	35	ExoN	ExoN	NNP
cord-349417-vn7q8wc4	14	36	,	,	,
cord-349417-vn7q8wc4	14	37	3'-to-5	3'-to-5	CD
cord-349417-vn7q8wc4	14	38	'	'	''
cord-349417-vn7q8wc4	14	39	exoribonuclease	exoribonuclease	NN
cord-349417-vn7q8wc4	14	40	;	;	:
cord-349417-vn7q8wc4	14	41	NendoU	NendoU	NNP
cord-349417-vn7q8wc4	14	42	,	,	,
cord-349417-vn7q8wc4	14	43	nidoviral	nidoviral	JJ
cord-349417-vn7q8wc4	14	44	uridylate	uridylate	JJ
cord-349417-vn7q8wc4	14	45	-	-	HYPH
cord-349417-vn7q8wc4	14	46	specific	specific	JJ
cord-349417-vn7q8wc4	14	47	endoribonuclease	endoribonuclease	NN
cord-349417-vn7q8wc4	14	48	;	;	:
cord-349417-vn7q8wc4	14	49	MT	MT	NNP
cord-349417-vn7q8wc4	14	50	,	,	,
cord-349417-vn7q8wc4	14	51	putative	putative	JJ
cord-349417-vn7q8wc4	14	52	ribose-2'-O	ribose-2'-o	JJ
cord-349417-vn7q8wc4	14	53	methyltransferase	methyltransferase	NN
cord-349417-vn7q8wc4	14	54	.	.	.
cord-349417-vn7q8wc4	15	1	Activation	activation	NN
cord-349417-vn7q8wc4	15	2	of	of	IN
cord-349417-vn7q8wc4	15	3	the	the	DT
cord-349417-vn7q8wc4	15	4	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	15	5	replication	replication	NN
cord-349417-vn7q8wc4	15	6	complex	complex	NN
cord-349417-vn7q8wc4	15	7	involves	involve	VBZ
cord-349417-vn7q8wc4	15	8	extensive	extensive	JJ
cord-349417-vn7q8wc4	15	9	proteolytic	proteolytic	JJ
cord-349417-vn7q8wc4	15	10	processing	processing	NN
cord-349417-vn7q8wc4	15	11	of	of	IN
cord-349417-vn7q8wc4	15	12	the	the	DT
cord-349417-vn7q8wc4	15	13	replicase	replicase	NN
cord-349417-vn7q8wc4	15	14	polyproteins	polyprotein	NNS
cord-349417-vn7q8wc4	15	15	to	to	TO
cord-349417-vn7q8wc4	15	16	produce	produce	VB
cord-349417-vn7q8wc4	15	17	16	16	CD
cord-349417-vn7q8wc4	15	18	(	(	-LRB-
cord-349417-vn7q8wc4	15	19	in	in	IN
cord-349417-vn7q8wc4	15	20	IBV	IBV	NNP
cord-349417-vn7q8wc4	15	21	:	:	:
cord-349417-vn7q8wc4	15	22	15	15	LS
cord-349417-vn7q8wc4	15	23	)	)	-RRB-
cord-349417-vn7q8wc4	15	24	mature	mature	JJ
cord-349417-vn7q8wc4	15	25	products	product	NNS
cord-349417-vn7q8wc4	15	26	called	call	VBN
cord-349417-vn7q8wc4	15	27	nonstructural	nonstructural	JJ
cord-349417-vn7q8wc4	15	28	proteins	protein	NNS
cord-349417-vn7q8wc4	15	29	(	(	-LRB-
cord-349417-vn7q8wc4	15	30	nsp	nsp	NN
cord-349417-vn7q8wc4	15	31	)	)	-RRB-
cord-349417-vn7q8wc4	15	32	1	1	CD
cord-349417-vn7q8wc4	15	33	to	to	IN
cord-349417-vn7q8wc4	15	34	16	16	CD
cord-349417-vn7q8wc4	15	35	(	(	-LRB-
cord-349417-vn7q8wc4	15	36	reviewed	review	VBN
cord-349417-vn7q8wc4	15	37	in	in	IN
cord-349417-vn7q8wc4	15	38	Refs	ref	NNS
cord-349417-vn7q8wc4	15	39	.	.	.
cord-349417-vn7q8wc4	16	1	3	3	CD
cord-349417-vn7q8wc4	16	2	and	and	CC
cord-349417-vn7q8wc4	16	3	15	15	CD
cord-349417-vn7q8wc4	16	4	)	)	-RRB-
cord-349417-vn7q8wc4	16	5	.	.	.
cord-349417-vn7q8wc4	17	1	The	the	DT
cord-349417-vn7q8wc4	17	2	processing	processing	NN
cord-349417-vn7q8wc4	17	3	involves	involve	VBZ
cord-349417-vn7q8wc4	17	4	two	two	CD
cord-349417-vn7q8wc4	17	5	different	different	JJ
cord-349417-vn7q8wc4	17	6	types	type	NNS
cord-349417-vn7q8wc4	17	7	of	of	IN
cord-349417-vn7q8wc4	17	8	proteases	protease	NNS
cord-349417-vn7q8wc4	17	9	.	.	.
cord-349417-vn7q8wc4	18	1	The	the	DT
cord-349417-vn7q8wc4	18	2	key	key	JJ
cord-349417-vn7q8wc4	18	3	enzyme	enzyme	NN
cord-349417-vn7q8wc4	18	4	is	be	VBZ
cord-349417-vn7q8wc4	18	5	the	the	DT
cord-349417-vn7q8wc4	18	6	so	so	RB
cord-349417-vn7q8wc4	18	7	-	-	HYPH
cord-349417-vn7q8wc4	18	8	called	call	VBN
cord-349417-vn7q8wc4	18	9	3C	3c	NN
cord-349417-vn7q8wc4	18	10	-	-	HYPH
cord-349417-vn7q8wc4	18	11	like	like	JJ
cord-349417-vn7q8wc4	18	12	protease	protease	NN
cord-349417-vn7q8wc4	18	13	(	(	-LRB-
cord-349417-vn7q8wc4	18	14	3CL	3CL	NNP
cord-349417-vn7q8wc4	18	15	pro	pro	JJ
cord-349417-vn7q8wc4	18	16	)	)	-RRB-
cord-349417-vn7q8wc4	18	17	,	,	,
cord-349417-vn7q8wc4	18	18	also	also	RB
cord-349417-vn7q8wc4	18	19	called	call	VBN
cord-349417-vn7q8wc4	18	20	main	main	JJ
cord-349417-vn7q8wc4	18	21	protease	protease	NN
cord-349417-vn7q8wc4	18	22	(	(	-LRB-
cord-349417-vn7q8wc4	18	23	M	M	NNP
cord-349417-vn7q8wc4	18	24	pro	pro	FW
cord-349417-vn7q8wc4	18	25	)	)	-RRB-
cord-349417-vn7q8wc4	18	26	,	,	,
cord-349417-vn7q8wc4	18	27	which	which	WDT
cord-349417-vn7q8wc4	18	28	cleaves	cleave	VBZ
cord-349417-vn7q8wc4	18	29	the	the	DT
cord-349417-vn7q8wc4	18	30	central	central	JJ
cord-349417-vn7q8wc4	18	31	and	and	CC
cord-349417-vn7q8wc4	18	32	C	c	NN
cord-349417-vn7q8wc4	18	33	-	-	HYPH
cord-349417-vn7q8wc4	18	34	terminal	terminal	NN
cord-349417-vn7q8wc4	18	35	regions	region	NNS
cord-349417-vn7q8wc4	18	36	of	of	IN
cord-349417-vn7q8wc4	18	37	pp1a	pp1a	NNP
cord-349417-vn7q8wc4	18	38	and	and	CC
cord-349417-vn7q8wc4	18	39	pp1ab	pp1ab	NNP
cord-349417-vn7q8wc4	18	40	at	at	IN
cord-349417-vn7q8wc4	18	41	11	11	CD
cord-349417-vn7q8wc4	18	42	conserved	conserve	VBN
cord-349417-vn7q8wc4	18	43	sites	site	NNS
cord-349417-vn7q8wc4	18	44	.	.	.
cord-349417-vn7q8wc4	19	1	15	15	CD
cord-349417-vn7q8wc4	19	2	3CL	3cl	CD
cord-349417-vn7q8wc4	19	3	pro	pro	NNP
cord-349417-vn7q8wc4	19	4	is	be	VBZ
cord-349417-vn7q8wc4	19	5	a	a	DT
cord-349417-vn7q8wc4	19	6	cysteine	cysteine	NN
cord-349417-vn7q8wc4	19	7	protease	protease	NN
cord-349417-vn7q8wc4	19	8	featuring	feature	VBG
cord-349417-vn7q8wc4	19	9	a	a	DT
cord-349417-vn7q8wc4	19	10	Cys	Cys	NNP
cord-349417-vn7q8wc4	19	11	-	-	HYPH
cord-349417-vn7q8wc4	19	12	His	-PRON-	PRP$
cord-349417-vn7q8wc4	19	13	catalytic	catalytic	JJ
cord-349417-vn7q8wc4	19	14	dyad	dyad	NN
cord-349417-vn7q8wc4	19	15	and	and	CC
cord-349417-vn7q8wc4	19	16	a	a	DT
cord-349417-vn7q8wc4	19	17	three	three	CD
cord-349417-vn7q8wc4	19	18	-	-	HYPH
cord-349417-vn7q8wc4	19	19	domain	domain	NN
cord-349417-vn7q8wc4	19	20	structure	structure	NN
cord-349417-vn7q8wc4	19	21	.	.	.
cord-349417-vn7q8wc4	20	1	16	16	CD
cord-349417-vn7q8wc4	20	2	,	,	,
cord-349417-vn7q8wc4	20	3	17	17	CD
cord-349417-vn7q8wc4	20	4	The	the	DT
cord-349417-vn7q8wc4	20	5	Nterminal	Nterminal	NNP
cord-349417-vn7q8wc4	20	6	domains	domain	NNS
cord-349417-vn7q8wc4	21	1	I	-PRON-	PRP
cord-349417-vn7q8wc4	21	2	and	and	CC
cord-349417-vn7q8wc4	21	3	II	II	NNP
cord-349417-vn7q8wc4	21	4	adopt	adopt	VB
cord-349417-vn7q8wc4	21	5	a	a	DT
cord-349417-vn7q8wc4	21	6	two	two	CD
cord-349417-vn7q8wc4	21	7	-	-	HYPH
cord-349417-vn7q8wc4	21	8	β	β	NN
cord-349417-vn7q8wc4	21	9	-	-	HYPH
cord-349417-vn7q8wc4	21	10	barrel	barrel	NN
cord-349417-vn7q8wc4	21	11	-	-	HYPH
cord-349417-vn7q8wc4	21	12	fold	fold	NN
cord-349417-vn7q8wc4	21	13	structure	structure	NN
cord-349417-vn7q8wc4	21	14	that	that	WDT
cord-349417-vn7q8wc4	21	15	resembles	resemble	VBZ
cord-349417-vn7q8wc4	21	16	the	the	DT
cord-349417-vn7q8wc4	21	17	structures	structure	NNS
cord-349417-vn7q8wc4	21	18	of	of	IN
cord-349417-vn7q8wc4	21	19	serine	serine	JJ
cord-349417-vn7q8wc4	21	20	proteases	protease	NNS
cord-349417-vn7q8wc4	21	21	of	of	IN
cord-349417-vn7q8wc4	21	22	the	the	DT
cord-349417-vn7q8wc4	21	23	chymotrypsin	chymotrypsin	NNP
cord-349417-vn7q8wc4	21	24	superfamily	superfamily	NNP
cord-349417-vn7q8wc4	21	25	.	.	.
cord-349417-vn7q8wc4	22	1	The	the	DT
cord-349417-vn7q8wc4	22	2	C	c	NN
cord-349417-vn7q8wc4	22	3	-	-	HYPH
cord-349417-vn7q8wc4	22	4	terminal	terminal	NN
cord-349417-vn7q8wc4	22	5	entirely	entirely	RB
cord-349417-vn7q8wc4	22	6	α	α	NN
cord-349417-vn7q8wc4	22	7	-	-	HYPH
cord-349417-vn7q8wc4	22	8	helical	helical	JJ
cord-349417-vn7q8wc4	22	9	domain	domain	NN
cord-349417-vn7q8wc4	22	10	III	III	NNP
cord-349417-vn7q8wc4	22	11	is	be	VBZ
cord-349417-vn7q8wc4	22	12	critically	critically	RB
cord-349417-vn7q8wc4	22	13	involved	involve	VBN
cord-349417-vn7q8wc4	22	14	in	in	IN
cord-349417-vn7q8wc4	22	15	proteolytic	proteolytic	JJ
cord-349417-vn7q8wc4	22	16	activity	activity	NN
cord-349417-vn7q8wc4	22	17	and	and	CC
cord-349417-vn7q8wc4	22	18	dimerization	dimerization	NN
cord-349417-vn7q8wc4	22	19	.	.	.
cord-349417-vn7q8wc4	23	1	It	-PRON-	PRP
cord-349417-vn7q8wc4	23	2	is	be	VBZ
cord-349417-vn7q8wc4	23	3	now	now	RB
cord-349417-vn7q8wc4	23	4	generally	generally	RB
cord-349417-vn7q8wc4	23	5	accepted	accept	VBN
cord-349417-vn7q8wc4	23	6	that	that	IN
cord-349417-vn7q8wc4	23	7	the	the	DT
cord-349417-vn7q8wc4	23	8	3CL	3cl	CD
cord-349417-vn7q8wc4	23	9	pro	pro	JJ
cord-349417-vn7q8wc4	23	10	dimer	dimer	NN
cord-349417-vn7q8wc4	23	11	represents	represent	VBZ
cord-349417-vn7q8wc4	23	12	the	the	DT
cord-349417-vn7q8wc4	23	13	active	active	JJ
cord-349417-vn7q8wc4	23	14	form	form	NN
cord-349417-vn7q8wc4	23	15	of	of	IN
cord-349417-vn7q8wc4	23	16	the	the	DT
cord-349417-vn7q8wc4	23	17	protease	protease	NN
cord-349417-vn7q8wc4	23	18	.	.	.
cord-349417-vn7q8wc4	24	1	18	18	CD
cord-349417-vn7q8wc4	24	2	,	,	,
cord-349417-vn7q8wc4	24	3	19	19	CD
cord-349417-vn7q8wc4	24	4	Intermolecular	Intermolecular	NNP
cord-349417-vn7q8wc4	24	5	interactions	interaction	NNS
cord-349417-vn7q8wc4	24	6	within	within	IN
cord-349417-vn7q8wc4	24	7	the	the	DT
cord-349417-vn7q8wc4	24	8	dimer	dimer	NN
cord-349417-vn7q8wc4	24	9	have	have	VBP
cord-349417-vn7q8wc4	24	10	been	be	VBN
cord-349417-vn7q8wc4	24	11	suggested	suggest	VBN
cord-349417-vn7q8wc4	24	12	to	to	TO
cord-349417-vn7q8wc4	24	13	keep	keep	VB
cord-349417-vn7q8wc4	24	14	the	the	DT
cord-349417-vn7q8wc4	24	15	active	active	JJ
cord-349417-vn7q8wc4	24	16	center	center	NN
cord-349417-vn7q8wc4	24	17	(	(	-LRB-
cord-349417-vn7q8wc4	24	18	in	in	IN
cord-349417-vn7q8wc4	24	19	particular	particular	JJ
cord-349417-vn7q8wc4	24	20	,	,	,
cord-349417-vn7q8wc4	24	21	the	the	DT
cord-349417-vn7q8wc4	24	22	S1	s1	NN
cord-349417-vn7q8wc4	24	23	subsite	subsite	NN
cord-349417-vn7q8wc4	24	24	)	)	-RRB-
cord-349417-vn7q8wc4	24	25	in	in	IN
cord-349417-vn7q8wc4	24	26	a	a	DT
cord-349417-vn7q8wc4	24	27	proteolytically	proteolytically	JJ
cord-349417-vn7q8wc4	24	28	competent	competent	JJ
cord-349417-vn7q8wc4	24	29	conformation	conformation	NN
cord-349417-vn7q8wc4	24	30	.	.	.
cord-349417-vn7q8wc4	25	1	17	17	CD
cord-349417-vn7q8wc4	25	2	,	,	,
cord-349417-vn7q8wc4	25	3	20	20	CD
cord-349417-vn7q8wc4	25	4	Coronavirus	Coronavirus	NNP
cord-349417-vn7q8wc4	25	5	main	main	JJ
cord-349417-vn7q8wc4	25	6	proteases	protease	NNS
cord-349417-vn7q8wc4	25	7	have	have	VBP
cord-349417-vn7q8wc4	25	8	conserved	conserve	VBN
cord-349417-vn7q8wc4	25	9	substrate	substrate	NN
cord-349417-vn7q8wc4	25	10	specificities	specificity	NNS
cord-349417-vn7q8wc4	25	11	[	[	-LRB-
cord-349417-vn7q8wc4	25	12	(	(	-LRB-
cord-349417-vn7q8wc4	25	13	L	L	NNP
cord-349417-vn7q8wc4	25	14	,	,	,
cord-349417-vn7q8wc4	25	15	I)-Q↓(S	I)-Q↓(S	NNP
cord-349417-vn7q8wc4	25	16	,	,	,
cord-349417-vn7q8wc4	25	17	A	A	NNP
cord-349417-vn7q8wc4	25	18	,	,	,
cord-349417-vn7q8wc4	25	19	G	G	NNP
cord-349417-vn7q8wc4	25	20	)	)	-RRB-
cord-349417-vn7q8wc4	25	21	]	]	-RRB-
cord-349417-vn7q8wc4	26	1	and	and	CC
cord-349417-vn7q8wc4	26	2	,	,	,
cord-349417-vn7q8wc4	26	3	accordingly	accordingly	RB
cord-349417-vn7q8wc4	26	4	,	,	,
cord-349417-vn7q8wc4	26	5	similar	similar	JJ
cord-349417-vn7q8wc4	26	6	substrate	substrate	NN
cord-349417-vn7q8wc4	26	7	-	-	HYPH
cord-349417-vn7q8wc4	26	8	binding	bind	VBG
cord-349417-vn7q8wc4	26	9	pocket	pocket	NN
cord-349417-vn7q8wc4	26	10	structures	structure	NNS
cord-349417-vn7q8wc4	26	11	,	,	,
cord-349417-vn7q8wc4	26	12	as	as	IN
cord-349417-vn7q8wc4	26	13	has	have	VBZ
cord-349417-vn7q8wc4	26	14	been	be	VBN
cord-349417-vn7q8wc4	26	15	shown	show	VBN
cord-349417-vn7q8wc4	26	16	by	by	IN
cord-349417-vn7q8wc4	26	17	crystal	crystal	NN
cord-349417-vn7q8wc4	26	18	structure	structure	NN
cord-349417-vn7q8wc4	26	19	analyses	analysis	NNS
cord-349417-vn7q8wc4	26	20	of	of	IN
cord-349417-vn7q8wc4	26	21	main	main	JJ
cord-349417-vn7q8wc4	26	22	proteases	protease	NNS
cord-349417-vn7q8wc4	26	23	from	from	IN
cord-349417-vn7q8wc4	26	24	different	different	JJ
cord-349417-vn7q8wc4	26	25	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	26	26	genetic	genetic	JJ
cord-349417-vn7q8wc4	26	27	groups	group	NNS
cord-349417-vn7q8wc4	26	28	.	.	.
cord-349417-vn7q8wc4	27	1	17	17	CD
cord-349417-vn7q8wc4	27	2	,	,	,
cord-349417-vn7q8wc4	27	3	[	[	-LRB-
cord-349417-vn7q8wc4	27	4	21	21	CD
cord-349417-vn7q8wc4	27	5	]	]	-RRB-
cord-349417-vn7q8wc4	28	1	[	[	-LRB-
cord-349417-vn7q8wc4	28	2	22	22	CD
cord-349417-vn7q8wc4	28	3	]	]	-RRB-
cord-349417-vn7q8wc4	29	1	[	[	-LRB-
cord-349417-vn7q8wc4	29	2	23	23	CD
cord-349417-vn7q8wc4	29	3	]	]	-RRB-
cord-349417-vn7q8wc4	30	1	Based	base	VBN
cord-349417-vn7q8wc4	30	2	on	on	IN
cord-349417-vn7q8wc4	30	3	this	this	DT
cord-349417-vn7q8wc4	30	4	information	information	NN
cord-349417-vn7q8wc4	30	5	,	,	,
cord-349417-vn7q8wc4	30	6	protease	protease	NN
cord-349417-vn7q8wc4	30	7	inhibitors	inhibitor	NNS
cord-349417-vn7q8wc4	30	8	have	have	VBP
cord-349417-vn7q8wc4	30	9	been	be	VBN
cord-349417-vn7q8wc4	30	10	developed	develop	VBN
cord-349417-vn7q8wc4	30	11	that	that	IN
cord-349417-vn7q8wc4	30	12	effectively	effectively	RB
cord-349417-vn7q8wc4	30	13	inhibit	inhibit	VB
cord-349417-vn7q8wc4	30	14	a	a	DT
cord-349417-vn7q8wc4	30	15	broad	broad	JJ
cord-349417-vn7q8wc4	30	16	range	range	NN
cord-349417-vn7q8wc4	30	17	of	of	IN
cord-349417-vn7q8wc4	30	18	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	30	19	main	main	JJ
cord-349417-vn7q8wc4	30	20	proteases	protease	NNS
cord-349417-vn7q8wc4	30	21	.	.	.
cord-349417-vn7q8wc4	31	1	23	23	CD
cord-349417-vn7q8wc4	32	1	Potentially	potentially	RB
cord-349417-vn7q8wc4	32	2	,	,	,
cord-349417-vn7q8wc4	32	3	these	these	DT
cord-349417-vn7q8wc4	32	4	compounds	compound	NNS
cord-349417-vn7q8wc4	32	5	may	may	MD
cord-349417-vn7q8wc4	32	6	be	be	VB
cord-349417-vn7q8wc4	32	7	useful	useful	JJ
cord-349417-vn7q8wc4	32	8	for	for	IN
cord-349417-vn7q8wc4	32	9	treatment	treatment	NN
cord-349417-vn7q8wc4	32	10	of	of	IN
cord-349417-vn7q8wc4	32	11	known	know	VBN
cord-349417-vn7q8wc4	32	12	or	or	CC
cord-349417-vn7q8wc4	32	13	newly	newly	RB
cord-349417-vn7q8wc4	32	14	emerging	emerge	VBG
cord-349417-vn7q8wc4	32	15	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	32	16	infections	infection	NNS
cord-349417-vn7q8wc4	32	17	.	.	.
cord-349417-vn7q8wc4	33	1	The	the	DT
cord-349417-vn7q8wc4	33	2	N	n	CD
cord-349417-vn7q8wc4	33	3	-	-	HYPH
cord-349417-vn7q8wc4	33	4	terminal	terminal	NN
cord-349417-vn7q8wc4	33	5	regions	region	NNS
cord-349417-vn7q8wc4	33	6	of	of	IN
cord-349417-vn7q8wc4	33	7	the	the	DT
cord-349417-vn7q8wc4	33	8	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	33	9	polyproteins	polyprotein	NNS
cord-349417-vn7q8wc4	33	10	,	,	,
cord-349417-vn7q8wc4	33	11	which	which	WDT
cord-349417-vn7q8wc4	33	12	are	be	VBP
cord-349417-vn7q8wc4	33	13	poorly	poorly	RB
cord-349417-vn7q8wc4	33	14	conserved	conserve	VBN
cord-349417-vn7q8wc4	33	15	among	among	IN
cord-349417-vn7q8wc4	33	16	the	the	DT
cord-349417-vn7q8wc4	33	17	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	33	18	groups	group	NNS
cord-349417-vn7q8wc4	33	19	I	-PRON-	PRP
cord-349417-vn7q8wc4	33	20	,	,	,
cord-349417-vn7q8wc4	33	21	II	II	NNP
cord-349417-vn7q8wc4	33	22	,	,	,
cord-349417-vn7q8wc4	33	23	and	and	CC
cord-349417-vn7q8wc4	33	24	III	III	NNP
cord-349417-vn7q8wc4	33	25	,	,	,
cord-349417-vn7q8wc4	33	26	are	be	VBP
cord-349417-vn7q8wc4	33	27	cleaved	cleave	VBN
cord-349417-vn7q8wc4	33	28	at	at	IN
cord-349417-vn7q8wc4	33	29	two	two	CD
cord-349417-vn7q8wc4	33	30	(	(	-LRB-
cord-349417-vn7q8wc4	33	31	in	in	IN
cord-349417-vn7q8wc4	33	32	IBV	IBV	NNP
cord-349417-vn7q8wc4	33	33	)	)	-RRB-
cord-349417-vn7q8wc4	33	34	or	or	CC
cord-349417-vn7q8wc4	33	35	three	three	CD
cord-349417-vn7q8wc4	33	36	sites	site	NNS
cord-349417-vn7q8wc4	33	37	(	(	-LRB-
cord-349417-vn7q8wc4	33	38	in	in	IN
cord-349417-vn7q8wc4	33	39	all	all	DT
cord-349417-vn7q8wc4	33	40	other	other	JJ
cord-349417-vn7q8wc4	33	41	coronaviruses	coronaviruse	NNS
cord-349417-vn7q8wc4	33	42	)	)	-RRB-
cord-349417-vn7q8wc4	33	43	by	by	IN
cord-349417-vn7q8wc4	33	44	one	one	CD
cord-349417-vn7q8wc4	33	45	(	(	-LRB-
cord-349417-vn7q8wc4	33	46	IBV	IBV	NNP
cord-349417-vn7q8wc4	33	47	and	and	CC
cord-349417-vn7q8wc4	33	48	SARS	SARS	NNP
cord-349417-vn7q8wc4	33	49	-	-	HYPH
cord-349417-vn7q8wc4	33	50	CoV	CoV	NNP
cord-349417-vn7q8wc4	33	51	)	)	-RRB-
cord-349417-vn7q8wc4	33	52	or	or	CC
cord-349417-vn7q8wc4	33	53	two	two	CD
cord-349417-vn7q8wc4	33	54	zinc	zinc	NN
cord-349417-vn7q8wc4	33	55	-	-	HYPH
cord-349417-vn7q8wc4	33	56	finger	finger	NN
cord-349417-vn7q8wc4	33	57	-	-	HYPH
cord-349417-vn7q8wc4	33	58	containing	contain	VBG
cord-349417-vn7q8wc4	33	59	papain	papain	NN
cord-349417-vn7q8wc4	33	60	-	-	HYPH
cord-349417-vn7q8wc4	33	61	like	like	JJ
cord-349417-vn7q8wc4	33	62	cysteine	cysteine	NN
cord-349417-vn7q8wc4	33	63	proteases	protease	NNS
cord-349417-vn7q8wc4	33	64	called	call	VBN
cord-349417-vn7q8wc4	33	65	PL1	pl1	NN
cord-349417-vn7q8wc4	33	66	pro	pro	NNP
cord-349417-vn7q8wc4	33	67	and	and	CC
cord-349417-vn7q8wc4	33	68	PL2	PL2	NNP
cord-349417-vn7q8wc4	33	69	pro	pro	JJ
cord-349417-vn7q8wc4	33	70	.	.	NNP
cord-349417-vn7q8wc4	33	71	24	24	CD
cord-349417-vn7q8wc4	33	72	-	-	SYM
cord-349417-vn7q8wc4	33	73	32	32	CD
cord-349417-vn7q8wc4	33	74	PL	pl	NN
cord-349417-vn7q8wc4	33	75	pro	pro	JJ
cord-349417-vn7q8wc4	33	76	cleavage	cleavage	NN
cord-349417-vn7q8wc4	33	77	sites	site	NNS
cord-349417-vn7q8wc4	33	78	are	be	VBP
cord-349417-vn7q8wc4	33	79	usually	usually	RB
cord-349417-vn7q8wc4	33	80	flanked	flank	VBN
cord-349417-vn7q8wc4	33	81	by	by	IN
cord-349417-vn7q8wc4	33	82	small	small	JJ
cord-349417-vn7q8wc4	33	83	residues	residue	NNS
cord-349417-vn7q8wc4	33	84	(	(	-LRB-
cord-349417-vn7q8wc4	33	85	mainly	mainly	RB
cord-349417-vn7q8wc4	33	86	Gly	Gly	NNP
cord-349417-vn7q8wc4	33	87	and	and	CC
cord-349417-vn7q8wc4	33	88	Ala	Ala	NNP
cord-349417-vn7q8wc4	33	89	)	)	-RRB-
cord-349417-vn7q8wc4	33	90	.	.	.
cord-349417-vn7q8wc4	34	1	15	15	CD
cord-349417-vn7q8wc4	34	2	PL1	pl1	NN
cord-349417-vn7q8wc4	34	3	pro	pro	JJ
cord-349417-vn7q8wc4	34	4	and	and	CC
cord-349417-vn7q8wc4	34	5	PL2	PL2	NNP
cord-349417-vn7q8wc4	34	6	pro	pro	RB
cord-349417-vn7q8wc4	34	7	probably	probably	RB
cord-349417-vn7q8wc4	34	8	evolved	evolve	VBN
cord-349417-vn7q8wc4	34	9	by	by	IN
cord-349417-vn7q8wc4	34	10	gene	gene	NN
cord-349417-vn7q8wc4	34	11	duplication	duplication	NN
cord-349417-vn7q8wc4	34	12	in	in	IN
cord-349417-vn7q8wc4	34	13	one	one	CD
cord-349417-vn7q8wc4	34	14	of	of	IN
cord-349417-vn7q8wc4	34	15	the	the	DT
cord-349417-vn7q8wc4	34	16	ancestors	ancestor	NNS
cord-349417-vn7q8wc4	34	17	of	of	IN
cord-349417-vn7q8wc4	34	18	the	the	DT
cord-349417-vn7q8wc4	34	19	present	present	JJ
cord-349417-vn7q8wc4	34	20	-	-	HYPH
cord-349417-vn7q8wc4	34	21	day	day	NN
cord-349417-vn7q8wc4	34	22	coronaviruses	coronaviruse	NNS
cord-349417-vn7q8wc4	34	23	.	.	.
cord-349417-vn7q8wc4	35	1	29	29	CD
cord-349417-vn7q8wc4	36	1	For	for	IN
cord-349417-vn7q8wc4	36	2	MHV	MHV	NNP
cord-349417-vn7q8wc4	36	3	,	,	,
cord-349417-vn7q8wc4	36	4	it	-PRON-	PRP
cord-349417-vn7q8wc4	36	5	was	be	VBD
cord-349417-vn7q8wc4	36	6	recently	recently	RB
cord-349417-vn7q8wc4	36	7	demonstrated	demonstrate	VBN
cord-349417-vn7q8wc4	36	8	that	that	IN
cord-349417-vn7q8wc4	36	9	cleavage	cleavage	NN
cord-349417-vn7q8wc4	36	10	of	of	IN
cord-349417-vn7q8wc4	36	11	the	the	DT
cord-349417-vn7q8wc4	36	12	nsp1|nsp2	nsp1|nsp2	NNP
cord-349417-vn7q8wc4	36	13	site	site	NN
cord-349417-vn7q8wc4	36	14	and	and	CC
cord-349417-vn7q8wc4	36	15	,	,	,
cord-349417-vn7q8wc4	36	16	even	even	RB
cord-349417-vn7q8wc4	36	17	more	more	RBR
cord-349417-vn7q8wc4	36	18	suprisingly	suprisingly	RB
cord-349417-vn7q8wc4	36	19	,	,	,
cord-349417-vn7q8wc4	36	20	the	the	DT
cord-349417-vn7q8wc4	36	21	C	c	NN
cord-349417-vn7q8wc4	36	22	-	-	HYPH
cord-349417-vn7q8wc4	36	23	terminal	terminal	NN
cord-349417-vn7q8wc4	36	24	nsp1	nsp1	NNS
cord-349417-vn7q8wc4	36	25	and	and	CC
cord-349417-vn7q8wc4	36	26	the	the	DT
cord-349417-vn7q8wc4	36	27	entire	entire	JJ
cord-349417-vn7q8wc4	36	28	nsp2	nsp2	JJR
cord-349417-vn7q8wc4	36	29	sequence	sequence	NN
cord-349417-vn7q8wc4	36	30	are	be	VBP
cord-349417-vn7q8wc4	36	31	not	not	RB
cord-349417-vn7q8wc4	36	32	required	require	VBN
cord-349417-vn7q8wc4	36	33	for	for	IN
cord-349417-vn7q8wc4	36	34	MHV	MHV	NNP
cord-349417-vn7q8wc4	36	35	replication	replication	NN
cord-349417-vn7q8wc4	36	36	in	in	IN
cord-349417-vn7q8wc4	36	37	vitro	vitro	FW
cord-349417-vn7q8wc4	36	38	.	.	.
cord-349417-vn7q8wc4	37	1	[	[	-LRB-
cord-349417-vn7q8wc4	37	2	33	33	CD
cord-349417-vn7q8wc4	37	3	]	]	-RRB-
cord-349417-vn7q8wc4	37	4	[	[	-LRB-
cord-349417-vn7q8wc4	37	5	34	34	CD
cord-349417-vn7q8wc4	37	6	]	]	-RRB-
cord-349417-vn7q8wc4	38	1	[	[	-LRB-
cord-349417-vn7q8wc4	38	2	35	35	CD
cord-349417-vn7q8wc4	38	3	]	]	-RRB-
cord-349417-vn7q8wc4	38	4	 	 	_SP
cord-349417-vn7q8wc4	39	1	The	the	DT
cord-349417-vn7q8wc4	39	2	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	39	3	RdRp	RdRp	NNP
cord-349417-vn7q8wc4	39	4	has	have	VBZ
cord-349417-vn7q8wc4	39	5	been	be	VBN
cord-349417-vn7q8wc4	39	6	classified	classify	VBN
cord-349417-vn7q8wc4	39	7	as	as	IN
cord-349417-vn7q8wc4	39	8	an	an	DT
cord-349417-vn7q8wc4	39	9	outgroup	outgroup	NN
cord-349417-vn7q8wc4	39	10	of	of	IN
cord-349417-vn7q8wc4	39	11	the	the	DT
cord-349417-vn7q8wc4	39	12	RdRp	RdRp	NNP
cord-349417-vn7q8wc4	39	13	superfamily	superfamily	NN
cord-349417-vn7q8wc4	39	14	1	1	CD
cord-349417-vn7q8wc4	39	15	.	.	.
cord-349417-vn7q8wc4	40	1	36	36	CD
cord-349417-vn7q8wc4	41	1	It	-PRON-	PRP
cord-349417-vn7q8wc4	41	2	resides	reside	VBZ
cord-349417-vn7q8wc4	41	3	in	in	IN
cord-349417-vn7q8wc4	41	4	the	the	DT
cord-349417-vn7q8wc4	41	5	ORF1b	ORF1b	NNP
cord-349417-vn7q8wc4	41	6	-	-	HYPH
cord-349417-vn7q8wc4	41	7	encoded	encode	VBN
cord-349417-vn7q8wc4	41	8	nonstructural	nonstructural	JJ
cord-349417-vn7q8wc4	41	9	proteins	protein	NNS
cord-349417-vn7q8wc4	41	10	12	12	CD
cord-349417-vn7q8wc4	41	11	,	,	,
cord-349417-vn7q8wc4	41	12	as	as	IN
cord-349417-vn7q8wc4	41	13	was	be	VBD
cord-349417-vn7q8wc4	41	14	predicted	predict	VBN
cord-349417-vn7q8wc4	41	15	about	about	IN
cord-349417-vn7q8wc4	41	16	15	15	CD
cord-349417-vn7q8wc4	41	17	years	year	NNS
cord-349417-vn7q8wc4	41	18	ago	ago	RB
cord-349417-vn7q8wc4	41	19	6	6	CD
cord-349417-vn7q8wc4	41	20	and	and	CC
cord-349417-vn7q8wc4	41	21	now	now	RB
cord-349417-vn7q8wc4	41	22	demonstrated	demonstrate	VBN
cord-349417-vn7q8wc4	41	23	for	for	IN
cord-349417-vn7q8wc4	41	24	a	a	DT
cord-349417-vn7q8wc4	41	25	bacterially	bacterially	RB
cord-349417-vn7q8wc4	41	26	expressed	express	VBN
cord-349417-vn7q8wc4	41	27	form	form	NN
cord-349417-vn7q8wc4	41	28	of	of	IN
cord-349417-vn7q8wc4	41	29	the	the	DT
cord-349417-vn7q8wc4	41	30	SARS	SARS	NNP
cord-349417-vn7q8wc4	41	31	-	-	HYPH
cord-349417-vn7q8wc4	41	32	CoV	CoV	NNP
cord-349417-vn7q8wc4	41	33	nsp12	nsp12	CD
cord-349417-vn7q8wc4	41	34	.	.	.
cord-349417-vn7q8wc4	42	1	37	37	CD
cord-349417-vn7q8wc4	43	1	The	the	DT
cord-349417-vn7q8wc4	43	2	RdRp	RdRp	NNP
cord-349417-vn7q8wc4	43	3	catalytic	catalytic	JJ
cord-349417-vn7q8wc4	43	4	domain	domain	NN
cord-349417-vn7q8wc4	43	5	occupies	occupy	VBZ
cord-349417-vn7q8wc4	43	6	the	the	DT
cord-349417-vn7q8wc4	43	7	C	C	NNP
cord-349417-vn7q8wc4	43	8	-	-	HYPH
cord-349417-vn7q8wc4	43	9	terminal	terminal	NN
cord-349417-vn7q8wc4	43	10	two	two	CD
cord-349417-vn7q8wc4	43	11	-	-	HYPH
cord-349417-vn7q8wc4	43	12	thirds	third	NNS
cord-349417-vn7q8wc4	43	13	of	of	IN
cord-349417-vn7q8wc4	43	14	nsp12	nsp12	CD
cord-349417-vn7q8wc4	43	15	,	,	,
cord-349417-vn7q8wc4	43	16	6	6	CD
cord-349417-vn7q8wc4	43	17	but	but	CC
cord-349417-vn7q8wc4	43	18	also	also	RB
cord-349417-vn7q8wc4	44	1	the	the	DT
cord-349417-vn7q8wc4	44	2	N	n	CD
cord-349417-vn7q8wc4	44	3	-	-	HYPH
cord-349417-vn7q8wc4	44	4	terminal	terminal	JJ
cord-349417-vn7q8wc4	44	5	part	part	NN
cord-349417-vn7q8wc4	44	6	of	of	IN
cord-349417-vn7q8wc4	44	7	nsp12	nsp12	NNP
cord-349417-vn7q8wc4	44	8	seems	seem	VBZ
cord-349417-vn7q8wc4	44	9	to	to	TO
cord-349417-vn7q8wc4	44	10	contribute	contribute	VB
cord-349417-vn7q8wc4	44	11	to	to	IN
cord-349417-vn7q8wc4	44	12	activity	activity	NN
cord-349417-vn7q8wc4	44	13	.	.	.
cord-349417-vn7q8wc4	45	1	37	37	CD
cord-349417-vn7q8wc4	46	1	Based	base	VBN
cord-349417-vn7q8wc4	46	2	on	on	IN
cord-349417-vn7q8wc4	46	3	MHV	MHV	NNP
cord-349417-vn7q8wc4	46	4	coimmunoprecipitation	coimmunoprecipitation	NN
cord-349417-vn7q8wc4	46	5	data	datum	NNS
cord-349417-vn7q8wc4	46	6	,	,	,
cord-349417-vn7q8wc4	46	7	the	the	DT
cord-349417-vn7q8wc4	46	8	N	n	CD
cord-349417-vn7q8wc4	46	9	-	-	HYPH
cord-349417-vn7q8wc4	46	10	terminal	terminal	JJ
cord-349417-vn7q8wc4	46	11	part	part	NN
cord-349417-vn7q8wc4	46	12	of	of	IN
cord-349417-vn7q8wc4	46	13	nsp12	nsp12	NNP
cord-349417-vn7q8wc4	46	14	has	have	VBZ
cord-349417-vn7q8wc4	46	15	been	be	VBN
cord-349417-vn7q8wc4	46	16	suggested	suggest	VBN
cord-349417-vn7q8wc4	46	17	to	to	TO
cord-349417-vn7q8wc4	46	18	interact	interact	VB
cord-349417-vn7q8wc4	46	19	with	with	IN
cord-349417-vn7q8wc4	46	20	other	other	JJ
cord-349417-vn7q8wc4	46	21	replicase	replicase	NN
cord-349417-vn7q8wc4	46	22	subunits	subunit	NNS
cord-349417-vn7q8wc4	46	23	,	,	,
cord-349417-vn7q8wc4	46	24	specifically	specifically	RB
cord-349417-vn7q8wc4	46	25	with	with	IN
cord-349417-vn7q8wc4	46	26	nsp5	nsp5	NN
cord-349417-vn7q8wc4	46	27	(	(	-LRB-
cord-349417-vn7q8wc4	46	28	3CL	3CL	NNP
cord-349417-vn7q8wc4	46	29	pro	pro	JJ
cord-349417-vn7q8wc4	46	30	)	)	-RRB-
cord-349417-vn7q8wc4	46	31	,	,	,
cord-349417-vn7q8wc4	46	32	nsp8	nsp8	NN
cord-349417-vn7q8wc4	46	33	,	,	,
cord-349417-vn7q8wc4	46	34	and	and	CC
cord-349417-vn7q8wc4	46	35	nsp9	nsp9	NNP
cord-349417-vn7q8wc4	46	36	,	,	,
cord-349417-vn7q8wc4	46	37	38	38	CD
cord-349417-vn7q8wc4	46	38	which	which	WDT
cord-349417-vn7q8wc4	46	39	is	be	VBZ
cord-349417-vn7q8wc4	46	40	in	in	IN
cord-349417-vn7q8wc4	46	41	line	line	NN
cord-349417-vn7q8wc4	46	42	with	with	IN
cord-349417-vn7q8wc4	46	43	the	the	DT
cord-349417-vn7q8wc4	46	44	recently	recently	RB
cord-349417-vn7q8wc4	46	45	published	publish	VBN
cord-349417-vn7q8wc4	46	46	crystal	crystal	JJ
cord-349417-vn7q8wc4	46	47	structure	structure	NN
cord-349417-vn7q8wc4	46	48	of	of	IN
cord-349417-vn7q8wc4	46	49	an	an	DT
cord-349417-vn7q8wc4	46	50	nsp7-nsp8	nsp7-nsp8	NNP
cord-349417-vn7q8wc4	46	51	complex	complex	NN
cord-349417-vn7q8wc4	46	52	from	from	IN
cord-349417-vn7q8wc4	46	53	SARS	SARS	NNP
cord-349417-vn7q8wc4	46	54	-	-	HYPH
cord-349417-vn7q8wc4	46	55	CoV.	CoV.	NNP
cord-349417-vn7q8wc4	46	56	39	39	CD
cord-349417-vn7q8wc4	47	1	The	the	DT
cord-349417-vn7q8wc4	47	2	X	x	NN
cord-349417-vn7q8wc4	47	3	-	-	NN
cord-349417-vn7q8wc4	47	4	ray	ray	NN
cord-349417-vn7q8wc4	47	5	crystallography	crystallography	NN
cord-349417-vn7q8wc4	47	6	study	study	NN
cord-349417-vn7q8wc4	47	7	by	by	IN
cord-349417-vn7q8wc4	47	8	Zhai	Zhai	NNP
cord-349417-vn7q8wc4	47	9	et	et	NNP
cord-349417-vn7q8wc4	47	10	al	al	NNP
cord-349417-vn7q8wc4	47	11	.	.	.
cord-349417-vn7q8wc4	48	1	39	39	CD
cord-349417-vn7q8wc4	48	2	provides	provide	VBZ
cord-349417-vn7q8wc4	48	3	first	first	JJ
cord-349417-vn7q8wc4	48	4	insights	insight	NNS
cord-349417-vn7q8wc4	48	5	into	into	IN
cord-349417-vn7q8wc4	48	6	the	the	DT
cord-349417-vn7q8wc4	48	7	sophisticated	sophisticated	JJ
cord-349417-vn7q8wc4	48	8	architecture	architecture	NN
cord-349417-vn7q8wc4	48	9	of	of	IN
cord-349417-vn7q8wc4	48	10	the	the	DT
cord-349417-vn7q8wc4	48	11	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	48	12	replicase	replicase	NN
cord-349417-vn7q8wc4	48	13	.	.	.
cord-349417-vn7q8wc4	49	1	It	-PRON-	PRP
cord-349417-vn7q8wc4	49	2	shows	show	VBZ
cord-349417-vn7q8wc4	49	3	that	that	IN
cord-349417-vn7q8wc4	49	4	eight	eight	CD
cord-349417-vn7q8wc4	49	5	molecules	molecule	NNS
cord-349417-vn7q8wc4	49	6	of	of	IN
cord-349417-vn7q8wc4	49	7	each	each	DT
cord-349417-vn7q8wc4	49	8	nsp7	nsp7	NN
cord-349417-vn7q8wc4	49	9	and	and	CC
cord-349417-vn7q8wc4	49	10	nsp8	nsp8	NN
cord-349417-vn7q8wc4	49	11	assemble	assemble	VBP
cord-349417-vn7q8wc4	49	12	into	into	IN
cord-349417-vn7q8wc4	49	13	a	a	DT
cord-349417-vn7q8wc4	49	14	hexadecameric	hexadecameric	JJ
cord-349417-vn7q8wc4	49	15	supercomplex	supercomplex	NN
cord-349417-vn7q8wc4	49	16	that	that	WDT
cord-349417-vn7q8wc4	49	17	forms	form	VBZ
cord-349417-vn7q8wc4	49	18	a	a	DT
cord-349417-vn7q8wc4	49	19	hollow	hollow	JJ
cord-349417-vn7q8wc4	49	20	,	,	,
cord-349417-vn7q8wc4	49	21	cylinder	cylinder	NN
cord-349417-vn7q8wc4	49	22	-	-	HYPH
cord-349417-vn7q8wc4	49	23	like	like	JJ
cord-349417-vn7q8wc4	49	24	structure	structure	NN
cord-349417-vn7q8wc4	49	25	,	,	,
cord-349417-vn7q8wc4	49	26	which	which	WDT
cord-349417-vn7q8wc4	49	27	,	,	,
cord-349417-vn7q8wc4	49	28	because	because	IN
cord-349417-vn7q8wc4	49	29	of	of	IN
cord-349417-vn7q8wc4	49	30	its	-PRON-	PRP$
cord-349417-vn7q8wc4	49	31	internal	internal	JJ
cord-349417-vn7q8wc4	49	32	dimensions	dimension	NNS
cord-349417-vn7q8wc4	49	33	and	and	CC
cord-349417-vn7q8wc4	49	34	electrostatic	electrostatic	JJ
cord-349417-vn7q8wc4	49	35	properties	property	NNS
cord-349417-vn7q8wc4	49	36	,	,	,
cord-349417-vn7q8wc4	49	37	seems	seem	VBZ
cord-349417-vn7q8wc4	49	38	to	to	TO
cord-349417-vn7q8wc4	49	39	be	be	VB
cord-349417-vn7q8wc4	49	40	capable	capable	JJ
cord-349417-vn7q8wc4	49	41	of	of	IN
cord-349417-vn7q8wc4	49	42	encircling	encircle	VBG
cord-349417-vn7q8wc4	49	43	RNA	RNA	NNP
cord-349417-vn7q8wc4	49	44	.	.	.
cord-349417-vn7q8wc4	50	1	This	this	DT
cord-349417-vn7q8wc4	50	2	nsp7-nsp8	nsp7-nsp8	CD
cord-349417-vn7q8wc4	51	1	supercomplex	supercomplex	NNP
cord-349417-vn7q8wc4	51	2	,	,	,
cord-349417-vn7q8wc4	51	3	in	in	IN
cord-349417-vn7q8wc4	51	4	turn	turn	NN
cord-349417-vn7q8wc4	51	5	,	,	,
cord-349417-vn7q8wc4	51	6	interacts	interact	VBZ
cord-349417-vn7q8wc4	51	7	with	with	IN
cord-349417-vn7q8wc4	51	8	nsp9	nsp9	NNP
cord-349417-vn7q8wc4	51	9	,	,	,
cord-349417-vn7q8wc4	51	10	a	a	DT
cord-349417-vn7q8wc4	51	11	small	small	JJ
cord-349417-vn7q8wc4	51	12	single	single	JJ
cord-349417-vn7q8wc4	51	13	-	-	HYPH
cord-349417-vn7q8wc4	51	14	stranded	strand	VBN
cord-349417-vn7q8wc4	51	15	RNA	rna	NN
cord-349417-vn7q8wc4	51	16	-	-	HYPH
cord-349417-vn7q8wc4	51	17	binding	bind	VBG
cord-349417-vn7q8wc4	51	18	protein	protein	NN
cord-349417-vn7q8wc4	51	19	,	,	,
cord-349417-vn7q8wc4	51	20	40	40	CD
cord-349417-vn7q8wc4	51	21	,	,	,
cord-349417-vn7q8wc4	51	22	41	41	CD
cord-349417-vn7q8wc4	51	23	and	and	CC
cord-349417-vn7q8wc4	51	24	interactions	interaction	NNS
cord-349417-vn7q8wc4	51	25	of	of	IN
cord-349417-vn7q8wc4	51	26	nsp7-nsp8(-nsp9	nsp7-nsp8(-nsp9	NNP
cord-349417-vn7q8wc4	51	27	)	)	-RRB-
cord-349417-vn7q8wc4	51	28	with	with	IN
cord-349417-vn7q8wc4	51	29	yet	yet	RB
cord-349417-vn7q8wc4	51	30	other	other	JJ
cord-349417-vn7q8wc4	51	31	replicase	replicase	NN
cord-349417-vn7q8wc4	51	32	subunits	subunit	NNS
cord-349417-vn7q8wc4	51	33	(	(	-LRB-
cord-349417-vn7q8wc4	51	34	including	include	VBG
cord-349417-vn7q8wc4	51	35	nsp12	nsp12	CD
cord-349417-vn7q8wc4	51	36	)	)	-RRB-
cord-349417-vn7q8wc4	51	37	are	be	VBP
cord-349417-vn7q8wc4	51	38	likely	likely	JJ
cord-349417-vn7q8wc4	51	39	.	.	.
cord-349417-vn7q8wc4	52	1	On	on	IN
cord-349417-vn7q8wc4	52	2	the	the	DT
cord-349417-vn7q8wc4	52	3	basis	basis	NN
cord-349417-vn7q8wc4	52	4	of	of	IN
cord-349417-vn7q8wc4	52	5	structural	structural	JJ
cord-349417-vn7q8wc4	52	6	and	and	CC
cord-349417-vn7q8wc4	52	7	functional	functional	JJ
cord-349417-vn7q8wc4	52	8	data	datum	NNS
cord-349417-vn7q8wc4	52	9	,	,	,
cord-349417-vn7q8wc4	52	10	it	-PRON-	PRP
cord-349417-vn7q8wc4	52	11	has	have	VBZ
cord-349417-vn7q8wc4	52	12	been	be	VBN
cord-349417-vn7q8wc4	52	13	speculated	speculate	VBN
cord-349417-vn7q8wc4	52	14	that	that	IN
cord-349417-vn7q8wc4	52	15	the	the	DT
cord-349417-vn7q8wc4	52	16	nsp7-nsp8	nsp7-nsp8	NNP
cord-349417-vn7q8wc4	52	17	complex	complex	NN
cord-349417-vn7q8wc4	52	18	might	may	MD
cord-349417-vn7q8wc4	52	19	act	act	VB
cord-349417-vn7q8wc4	52	20	as	as	IN
cord-349417-vn7q8wc4	52	21	an	an	DT
cord-349417-vn7q8wc4	52	22	important	important	JJ
cord-349417-vn7q8wc4	52	23	RdRp	rdrp	NN
cord-349417-vn7q8wc4	52	24	cofactor	cofactor	NN
cord-349417-vn7q8wc4	52	25	,	,	,
cord-349417-vn7q8wc4	52	26	for	for	IN
cord-349417-vn7q8wc4	52	27	example	example	NN
cord-349417-vn7q8wc4	52	28	,	,	,
cord-349417-vn7q8wc4	52	29	to	to	TO
cord-349417-vn7q8wc4	52	30	increase	increase	VB
cord-349417-vn7q8wc4	52	31	the	the	DT
cord-349417-vn7q8wc4	52	32	RdRp	RdRp	NNP
cord-349417-vn7q8wc4	52	33	processivity	processivity	NN
cord-349417-vn7q8wc4	52	34	.	.	.
cord-349417-vn7q8wc4	53	1	39	39	CD
cord-349417-vn7q8wc4	53	2	Evidence	evidence	NN
cord-349417-vn7q8wc4	53	3	for	for	IN
cord-349417-vn7q8wc4	53	4	a	a	DT
cord-349417-vn7q8wc4	53	5	critical	critical	JJ
cord-349417-vn7q8wc4	53	6	involvement	involvement	NN
cord-349417-vn7q8wc4	53	7	of	of	IN
cord-349417-vn7q8wc4	53	8	the	the	DT
cord-349417-vn7q8wc4	53	9	C	C	NNP
cord-349417-vn7q8wc4	53	10	-	-	HYPH
cord-349417-vn7q8wc4	53	11	terminal	terminal	NNP
cord-349417-vn7q8wc4	53	12	pp1a	pp1a	NNP
cord-349417-vn7q8wc4	53	13	processing	processing	NN
cord-349417-vn7q8wc4	53	14	products	product	NNS
cord-349417-vn7q8wc4	53	15	(	(	-LRB-
cord-349417-vn7q8wc4	53	16	nsp7	nsp7	NNP
cord-349417-vn7q8wc4	53	17	-	-	SYM
cord-349417-vn7q8wc4	53	18	10	10	CD
cord-349417-vn7q8wc4	53	19	)	)	-RRB-
cord-349417-vn7q8wc4	53	20	in	in	IN
cord-349417-vn7q8wc4	53	21	viral	viral	JJ
cord-349417-vn7q8wc4	53	22	RNA	RNA	NNP
cord-349417-vn7q8wc4	53	23	synthesis	synthesis	NN
cord-349417-vn7q8wc4	53	24	also	also	RB
cord-349417-vn7q8wc4	53	25	comes	come	VBZ
cord-349417-vn7q8wc4	53	26	from	from	IN
cord-349417-vn7q8wc4	53	27	work	work	NN
cord-349417-vn7q8wc4	53	28	on	on	IN
cord-349417-vn7q8wc4	53	29	MHV	MHV	NNP
cord-349417-vn7q8wc4	53	30	temperature	temperature	NN
cord-349417-vn7q8wc4	53	31	-	-	HYPH
cord-349417-vn7q8wc4	53	32	sensitive	sensitive	JJ
cord-349417-vn7q8wc4	53	33	mutants	mutant	NNS
cord-349417-vn7q8wc4	53	34	,	,	,
cord-349417-vn7q8wc4	53	35	which	which	WDT
cord-349417-vn7q8wc4	53	36	has	have	VBZ
cord-349417-vn7q8wc4	53	37	shown	show	VBN
cord-349417-vn7q8wc4	53	38	that	that	IN
cord-349417-vn7q8wc4	53	39	nsp10	nsp10	RB
cord-349417-vn7q8wc4	53	40	,	,	,
cord-349417-vn7q8wc4	53	41	a	a	DT
cord-349417-vn7q8wc4	53	42	Cys	Cys	NNP
cord-349417-vn7q8wc4	53	43	/	/	SYM
cord-349417-vn7q8wc4	53	44	His	-PRON-	PRP$
cord-349417-vn7q8wc4	53	45	-	-	HYPH
cord-349417-vn7q8wc4	53	46	rich	rich	JJ
cord-349417-vn7q8wc4	53	47	protein	protein	NN
cord-349417-vn7q8wc4	53	48	,	,	,
cord-349417-vn7q8wc4	53	49	has	have	VBZ
cord-349417-vn7q8wc4	53	50	a	a	DT
cord-349417-vn7q8wc4	53	51	distinct	distinct	JJ
cord-349417-vn7q8wc4	53	52	role	role	NN
cord-349417-vn7q8wc4	53	53	in	in	IN
cord-349417-vn7q8wc4	53	54	minus	minus	JJ
cord-349417-vn7q8wc4	53	55	-	-	HYPH
cord-349417-vn7q8wc4	53	56	strand	strand	NN
cord-349417-vn7q8wc4	53	57	RNA	RNA	NNP
cord-349417-vn7q8wc4	53	58	synthesis	synthesis	NN
cord-349417-vn7q8wc4	53	59	.	.	.
cord-349417-vn7q8wc4	54	1	42	42	CD
cord-349417-vn7q8wc4	55	1	After	after	IN
cord-349417-vn7q8wc4	55	2	the	the	DT
cord-349417-vn7q8wc4	55	3	RdRp	RdRp	NNP
cord-349417-vn7q8wc4	55	4	,	,	,
cord-349417-vn7q8wc4	55	5	helicases	helicase	NNS
cord-349417-vn7q8wc4	55	6	are	be	VBP
cord-349417-vn7q8wc4	55	7	the	the	DT
cord-349417-vn7q8wc4	55	8	second	second	RB
cord-349417-vn7q8wc4	55	9	best	good	JJS
cord-349417-vn7q8wc4	55	10	conserved	conserved	JJ
cord-349417-vn7q8wc4	55	11	enzymes	enzyme	NNS
cord-349417-vn7q8wc4	55	12	of	of	IN
cord-349417-vn7q8wc4	55	13	plus	plus	JJ
cord-349417-vn7q8wc4	55	14	-	-	HYPH
cord-349417-vn7q8wc4	55	15	strand	strand	NN
cord-349417-vn7q8wc4	55	16	RNA	RNA	NNP
cord-349417-vn7q8wc4	55	17	viruses	virus	NNS
cord-349417-vn7q8wc4	55	18	.	.	.
cord-349417-vn7q8wc4	56	1	The	the	DT
cord-349417-vn7q8wc4	56	2	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	56	3	helicase	helicase	NN
cord-349417-vn7q8wc4	56	4	resides	reside	VBZ
cord-349417-vn7q8wc4	56	5	in	in	IN
cord-349417-vn7q8wc4	56	6	nsp13	nsp13	NNP
cord-349417-vn7q8wc4	56	7	and	and	CC
cord-349417-vn7q8wc4	56	8	has	have	VBZ
cord-349417-vn7q8wc4	56	9	been	be	VBN
cord-349417-vn7q8wc4	56	10	classified	classify	VBN
cord-349417-vn7q8wc4	56	11	as	as	IN
cord-349417-vn7q8wc4	56	12	belonging	belong	VBG
cord-349417-vn7q8wc4	56	13	to	to	IN
cord-349417-vn7q8wc4	56	14	the	the	DT
cord-349417-vn7q8wc4	56	15	helicase	helicase	NNP
cord-349417-vn7q8wc4	56	16	superfamily	superfamily	NN
cord-349417-vn7q8wc4	56	17	1	1	CD
cord-349417-vn7q8wc4	56	18	6,43	6,43	CD
cord-349417-vn7q8wc4	57	1	(	(	-LRB-
cord-349417-vn7q8wc4	57	2	Fig	Fig	NNP
cord-349417-vn7q8wc4	57	3	.	.	NNP
cord-349417-vn7q8wc4	57	4	1	1	CD
cord-349417-vn7q8wc4	57	5	)	)	-RRB-
cord-349417-vn7q8wc4	57	6	.	.	.
cord-349417-vn7q8wc4	58	1	Coronavirus	Coronavirus	NNP
cord-349417-vn7q8wc4	58	2	helicases	helicase	NNS
cord-349417-vn7q8wc4	58	3	and	and	CC
cord-349417-vn7q8wc4	58	4	all	all	PDT
cord-349417-vn7q8wc4	58	5	their	-PRON-	PRP$
cord-349417-vn7q8wc4	58	6	nidovirus	nidovirus	NN
cord-349417-vn7q8wc4	58	7	homologs	homolog	NNS
cord-349417-vn7q8wc4	58	8	are	be	VBP
cord-349417-vn7q8wc4	58	9	linked	link	VBN
cord-349417-vn7q8wc4	58	10	to	to	IN
cord-349417-vn7q8wc4	58	11	an	an	DT
cord-349417-vn7q8wc4	58	12	N	n	CD
cord-349417-vn7q8wc4	58	13	-	-	HYPH
cord-349417-vn7q8wc4	58	14	terminal	terminal	NN
cord-349417-vn7q8wc4	58	15	zinc	zinc	NN
cord-349417-vn7q8wc4	58	16	-	-	HYPH
cord-349417-vn7q8wc4	58	17	binding	bind	VBG
cord-349417-vn7q8wc4	58	18	domain	domain	NN
cord-349417-vn7q8wc4	58	19	(	(	-LRB-
cord-349417-vn7q8wc4	58	20	ZBD	ZBD	NNP
cord-349417-vn7q8wc4	58	21	)	)	-RRB-
cord-349417-vn7q8wc4	58	22	involving	involve	VBG
cord-349417-vn7q8wc4	58	23	12	12	CD
cord-349417-vn7q8wc4	58	24	-	-	SYM
cord-349417-vn7q8wc4	58	25	13	13	CD
cord-349417-vn7q8wc4	58	26	conserved	conserve	VBN
cord-349417-vn7q8wc4	58	27	Cys	Cys	NNP
cord-349417-vn7q8wc4	58	28	/	/	SYM
cord-349417-vn7q8wc4	58	29	His	-PRON-	PRP$
cord-349417-vn7q8wc4	58	30	residues	residue	NNS
cord-349417-vn7q8wc4	58	31	.	.	.
cord-349417-vn7q8wc4	59	1	6	6	CD
cord-349417-vn7q8wc4	60	1	The	the	DT
cord-349417-vn7q8wc4	60	2	conservation	conservation	NN
cord-349417-vn7q8wc4	60	3	of	of	IN
cord-349417-vn7q8wc4	60	4	a	a	DT
cord-349417-vn7q8wc4	60	5	ZBD	ZBD	NNP
cord-349417-vn7q8wc4	60	6	-	-	HYPH
cord-349417-vn7q8wc4	60	7	associated	associate	VBN
cord-349417-vn7q8wc4	60	8	superfamily	superfamily	NN
cord-349417-vn7q8wc4	60	9	1	1	CD
cord-349417-vn7q8wc4	60	10	helicase	helicase	NNP
cord-349417-vn7q8wc4	60	11	is	be	VBZ
cord-349417-vn7q8wc4	60	12	considered	consider	VBN
cord-349417-vn7q8wc4	60	13	one	one	CD
cord-349417-vn7q8wc4	60	14	of	of	IN
cord-349417-vn7q8wc4	60	15	the	the	DT
cord-349417-vn7q8wc4	60	16	major	major	JJ
cord-349417-vn7q8wc4	60	17	genetic	genetic	JJ
cord-349417-vn7q8wc4	60	18	markers	marker	NNS
cord-349417-vn7q8wc4	60	19	of	of	IN
cord-349417-vn7q8wc4	60	20	nidoviruses	nidoviruse	NNS
cord-349417-vn7q8wc4	60	21	.	.	.
cord-349417-vn7q8wc4	61	1	Over	over	IN
cord-349417-vn7q8wc4	61	2	the	the	DT
cord-349417-vn7q8wc4	61	3	past	past	JJ
cord-349417-vn7q8wc4	61	4	years	year	NNS
cord-349417-vn7q8wc4	61	5	,	,	,
cord-349417-vn7q8wc4	61	6	the	the	DT
cord-349417-vn7q8wc4	61	7	helicase	helicase	NN
cord-349417-vn7q8wc4	61	8	activities	activity	NNS
cord-349417-vn7q8wc4	61	9	of	of	IN
cord-349417-vn7q8wc4	61	10	HCoV-229E	HCoV-229E	NNP
cord-349417-vn7q8wc4	61	11	and	and	CC
cord-349417-vn7q8wc4	61	12	,	,	,
cord-349417-vn7q8wc4	61	13	to	to	IN
cord-349417-vn7q8wc4	61	14	a	a	DT
cord-349417-vn7q8wc4	61	15	lesser	less	JJR
cord-349417-vn7q8wc4	61	16	extent	extent	NN
cord-349417-vn7q8wc4	61	17	,	,	,
cord-349417-vn7q8wc4	61	18	of	of	IN
cord-349417-vn7q8wc4	61	19	SARS	SARS	NNP
cord-349417-vn7q8wc4	61	20	-	-	HYPH
cord-349417-vn7q8wc4	61	21	CoV	CoV	NNP
cord-349417-vn7q8wc4	61	22	have	have	VBP
cord-349417-vn7q8wc4	61	23	been	be	VBN
cord-349417-vn7q8wc4	61	24	characterized	characterize	VBN
cord-349417-vn7q8wc4	61	25	.	.	.
cord-349417-vn7q8wc4	62	1	[	[	-LRB-
cord-349417-vn7q8wc4	62	2	44	44	CD
cord-349417-vn7q8wc4	62	3	]	]	-RRB-
cord-349417-vn7q8wc4	62	4	[	[	-LRB-
cord-349417-vn7q8wc4	62	5	45	45	CD
cord-349417-vn7q8wc4	62	6	]	]	-RRB-
cord-349417-vn7q8wc4	63	1	[	[	-LRB-
cord-349417-vn7q8wc4	63	2	46	46	CD
cord-349417-vn7q8wc4	63	3	]	]	-RRB-
cord-349417-vn7q8wc4	64	1	[	[	-LRB-
cord-349417-vn7q8wc4	64	2	47	47	CD
cord-349417-vn7q8wc4	64	3	]	]	-RRB-
cord-349417-vn7q8wc4	64	4	[	[	-LRB-
cord-349417-vn7q8wc4	64	5	48	48	CD
cord-349417-vn7q8wc4	64	6	]	]	-RRB-
cord-349417-vn7q8wc4	64	7	Mutagenesis	Mutagenesis	NNP
cord-349417-vn7q8wc4	64	8	and	and	CC
cord-349417-vn7q8wc4	64	9	biochemical	biochemical	JJ
cord-349417-vn7q8wc4	64	10	data	datum	NNS
cord-349417-vn7q8wc4	64	11	revealed	reveal	VBD
cord-349417-vn7q8wc4	64	12	that	that	IN
cord-349417-vn7q8wc4	64	13	the	the	DT
cord-349417-vn7q8wc4	64	14	ZBD	ZBD	NNP
cord-349417-vn7q8wc4	64	15	is	be	VBZ
cord-349417-vn7q8wc4	64	16	essential	essential	JJ
cord-349417-vn7q8wc4	64	17	for	for	IN
cord-349417-vn7q8wc4	64	18	the	the	DT
cord-349417-vn7q8wc4	64	19	enzymatic	enzymatic	JJ
cord-349417-vn7q8wc4	64	20	activities	activity	NNS
cord-349417-vn7q8wc4	64	21	of	of	IN
cord-349417-vn7q8wc4	64	22	both	both	CC
cord-349417-vn7q8wc4	64	23	the	the	DT
cord-349417-vn7q8wc4	64	24	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	64	25	and	and	CC
cord-349417-vn7q8wc4	64	26	arterivirus	arterivirus	NNP
cord-349417-vn7q8wc4	64	27	helicases	helicase	NNS
cord-349417-vn7q8wc4	64	28	.	.	.
cord-349417-vn7q8wc4	65	1	49	49	CD
cord-349417-vn7q8wc4	65	2	Coronavirus	Coronavirus	NNP
cord-349417-vn7q8wc4	65	3	helicases	helicase	NNS
cord-349417-vn7q8wc4	65	4	proved	prove	VBD
cord-349417-vn7q8wc4	65	5	to	to	TO
cord-349417-vn7q8wc4	65	6	have	have	VB
cord-349417-vn7q8wc4	65	7	multiple	multiple	JJ
cord-349417-vn7q8wc4	65	8	enzymatic	enzymatic	JJ
cord-349417-vn7q8wc4	65	9	activities	activity	NNS
cord-349417-vn7q8wc4	65	10	,	,	,
cord-349417-vn7q8wc4	65	11	including	include	VBG
cord-349417-vn7q8wc4	65	12	nucleic	nucleic	JJ
cord-349417-vn7q8wc4	65	13	acid	acid	NN
cord-349417-vn7q8wc4	65	14	-	-	HYPH
cord-349417-vn7q8wc4	65	15	stimulated	stimulate	VBN
cord-349417-vn7q8wc4	65	16	NTPase	NTPase	NNP
cord-349417-vn7q8wc4	65	17	,	,	,
cord-349417-vn7q8wc4	65	18	dNTPase	dNTPase	NNP
cord-349417-vn7q8wc4	65	19	,	,	,
cord-349417-vn7q8wc4	65	20	and	and	CC
cord-349417-vn7q8wc4	65	21	RNA	RNA	NNP
cord-349417-vn7q8wc4	65	22	(	(	-LRB-
cord-349417-vn7q8wc4	65	23	plus	plus	CC
cord-349417-vn7q8wc4	65	24	DNA	DNA	NNP
cord-349417-vn7q8wc4	65	25	)	)	-RRB-
cord-349417-vn7q8wc4	65	26	duplex	duplex	NN
cord-349417-vn7q8wc4	65	27	-	-	HYPH
cord-349417-vn7q8wc4	65	28	unwinding	unwind	VBG
cord-349417-vn7q8wc4	65	29	activities	activity	NNS
cord-349417-vn7q8wc4	65	30	.	.	.
cord-349417-vn7q8wc4	66	1	44	44	CD
cord-349417-vn7q8wc4	66	2	,	,	,
cord-349417-vn7q8wc4	66	3	47	47	CD
cord-349417-vn7q8wc4	66	4	,	,	,
cord-349417-vn7q8wc4	66	5	48	48	CD
cord-349417-vn7q8wc4	66	6	Coronavirus	Coronavirus	NNP
cord-349417-vn7q8wc4	66	7	(	(	-LRB-
cord-349417-vn7q8wc4	66	8	and	and	CC
cord-349417-vn7q8wc4	66	9	arterivirus	arterivirus	NNP
cord-349417-vn7q8wc4	66	10	)	)	-RRB-
cord-349417-vn7q8wc4	66	11	helicases	helicase	NNS
cord-349417-vn7q8wc4	66	12	were	be	VBD
cord-349417-vn7q8wc4	66	13	demonstrated	demonstrate	VBN
cord-349417-vn7q8wc4	66	14	to	to	TO
cord-349417-vn7q8wc4	66	15	unwind	unwind	VB
cord-349417-vn7q8wc4	66	16	double	double	RB
cord-349417-vn7q8wc4	66	17	-	-	HYPH
cord-349417-vn7q8wc4	66	18	stranded	strand	VBN
cord-349417-vn7q8wc4	66	19	RNA	RNA	NNP
cord-349417-vn7q8wc4	66	20	substrates	substrate	NNS
cord-349417-vn7q8wc4	66	21	with	with	IN
cord-349417-vn7q8wc4	66	22	5'-to-3	5'-to-3	CD
cord-349417-vn7q8wc4	66	23	'	'	''
cord-349417-vn7q8wc4	66	24	polarity	polarity	NN
cord-349417-vn7q8wc4	66	25	,	,	,
cord-349417-vn7q8wc4	66	26	that	that	RB
cord-349417-vn7q8wc4	66	27	is	is	RB
cord-349417-vn7q8wc4	66	28	,	,	,
cord-349417-vn7q8wc4	66	29	they	-PRON-	PRP
cord-349417-vn7q8wc4	66	30	move	move	VBP
cord-349417-vn7q8wc4	66	31	in	in	IN
cord-349417-vn7q8wc4	66	32	a	a	DT
cord-349417-vn7q8wc4	66	33	5'-to-3	5'-to-3	CD
cord-349417-vn7q8wc4	66	34	'	'	POS
cord-349417-vn7q8wc4	66	35	direction	direction	NN
cord-349417-vn7q8wc4	66	36	along	along	IN
cord-349417-vn7q8wc4	66	37	the	the	DT
cord-349417-vn7q8wc4	66	38	strand	strand	NN
cord-349417-vn7q8wc4	66	39	to	to	TO
cord-349417-vn7q8wc4	66	40	which	which	WDT
cord-349417-vn7q8wc4	66	41	they	-PRON-	PRP
cord-349417-vn7q8wc4	66	42	initially	initially	RB
cord-349417-vn7q8wc4	66	43	bind	bind	VBP
cord-349417-vn7q8wc4	66	44	.	.	.
cord-349417-vn7q8wc4	67	1	44	44	CD
cord-349417-vn7q8wc4	67	2	,	,	,
cord-349417-vn7q8wc4	67	3	50	50	CD
cord-349417-vn7q8wc4	68	1	The	the	DT
cord-349417-vn7q8wc4	68	2	polarity	polarity	NN
cord-349417-vn7q8wc4	68	3	of	of	IN
cord-349417-vn7q8wc4	68	4	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	68	5	helicase	helicase	NN
cord-349417-vn7q8wc4	68	6	activities	activity	NNS
cord-349417-vn7q8wc4	68	7	contrasts	contrast	VBZ
cord-349417-vn7q8wc4	68	8	with	with	IN
cord-349417-vn7q8wc4	68	9	that	that	DT
cord-349417-vn7q8wc4	68	10	of	of	IN
cord-349417-vn7q8wc4	68	11	the	the	DT
cord-349417-vn7q8wc4	68	12	helicases	helicase	NNS
cord-349417-vn7q8wc4	68	13	of	of	IN
cord-349417-vn7q8wc4	68	14	flavi-	flavi-	NN
cord-349417-vn7q8wc4	68	15	,	,	,
cord-349417-vn7q8wc4	68	16	pesti-	pesti-	NN
cord-349417-vn7q8wc4	68	17	,	,	,
cord-349417-vn7q8wc4	68	18	and	and	CC
cord-349417-vn7q8wc4	68	19	hepaciviruses	hepaciviruse	NNS
cord-349417-vn7q8wc4	68	20	,	,	,
cord-349417-vn7q8wc4	68	21	which	which	WDT
cord-349417-vn7q8wc4	68	22	all	all	DT
cord-349417-vn7q8wc4	68	23	operate	operate	VBP
cord-349417-vn7q8wc4	68	24	in	in	IN
cord-349417-vn7q8wc4	68	25	the	the	DT
cord-349417-vn7q8wc4	68	26	opposite	opposite	JJ
cord-349417-vn7q8wc4	68	27	direction	direction	NN
cord-349417-vn7q8wc4	68	28	,	,	,
cord-349417-vn7q8wc4	68	29	51	51	CD
cord-349417-vn7q8wc4	68	30	indicating	indicate	VBG
cord-349417-vn7q8wc4	68	31	that	that	IN
cord-349417-vn7q8wc4	68	32	the	the	DT
cord-349417-vn7q8wc4	68	33	biological	biological	JJ
cord-349417-vn7q8wc4	68	34	functions	function	NNS
cord-349417-vn7q8wc4	68	35	of	of	IN
cord-349417-vn7q8wc4	68	36	helicases	helicase	NNS
cord-349417-vn7q8wc4	68	37	from	from	IN
cord-349417-vn7q8wc4	68	38	the	the	DT
cord-349417-vn7q8wc4	68	39	Nidovirales	Nidovirales	NNP
cord-349417-vn7q8wc4	68	40	and	and	CC
cord-349417-vn7q8wc4	68	41	Flaviviridae	Flaviviridae	NNP
cord-349417-vn7q8wc4	68	42	might	may	MD
cord-349417-vn7q8wc4	68	43	differ	differ	VB
cord-349417-vn7q8wc4	68	44	fundamentally	fundamentally	RB
cord-349417-vn7q8wc4	68	45	from	from	IN
cord-349417-vn7q8wc4	68	46	each	each	DT
cord-349417-vn7q8wc4	68	47	other	other	JJ
cord-349417-vn7q8wc4	68	48	.	.	.
cord-349417-vn7q8wc4	69	1	Coronavirus	Coronavirus	NNP
cord-349417-vn7q8wc4	69	2	(	(	-LRB-
cord-349417-vn7q8wc4	69	3	nidovirus	nidovirus	NNP
cord-349417-vn7q8wc4	69	4	)	)	-RRB-
cord-349417-vn7q8wc4	69	5	helicases	helicase	NNS
cord-349417-vn7q8wc4	69	6	belong	belong	VBP
cord-349417-vn7q8wc4	69	7	to	to	IN
cord-349417-vn7q8wc4	69	8	the	the	DT
cord-349417-vn7q8wc4	69	9	few	few	JJ
cord-349417-vn7q8wc4	69	10	helicases	helicase	NNS
cord-349417-vn7q8wc4	69	11	that	that	WDT
cord-349417-vn7q8wc4	69	12	act	act	VBP
cord-349417-vn7q8wc4	69	13	on	on	IN
cord-349417-vn7q8wc4	69	14	both	both	CC
cord-349417-vn7q8wc4	69	15	RNA	RNA	NNP
cord-349417-vn7q8wc4	69	16	or	or	CC
cord-349417-vn7q8wc4	69	17	DNA	dna	NN
cord-349417-vn7q8wc4	69	18	substrates	substrate	NNS
cord-349417-vn7q8wc4	69	19	with	with	IN
cord-349417-vn7q8wc4	69	20	nearly	nearly	RB
cord-349417-vn7q8wc4	69	21	equal	equal	JJ
cord-349417-vn7q8wc4	69	22	efficacy	efficacy	NN
cord-349417-vn7q8wc4	69	23	.	.	.
cord-349417-vn7q8wc4	70	1	Given	give	VBN
cord-349417-vn7q8wc4	70	2	that	that	IN
cord-349417-vn7q8wc4	70	3	the	the	DT
cord-349417-vn7q8wc4	70	4	helicase	helicase	NN
cord-349417-vn7q8wc4	70	5	is	be	VBZ
cord-349417-vn7q8wc4	70	6	part	part	NN
cord-349417-vn7q8wc4	70	7	part	part	NN
cord-349417-vn7q8wc4	70	8	of	of	IN
cord-349417-vn7q8wc4	70	9	the	the	DT
cord-349417-vn7q8wc4	70	10	(	(	-LRB-
cord-349417-vn7q8wc4	70	11	cytoplasmic	cytoplasmic	JJ
cord-349417-vn7q8wc4	70	12	)	)	-RRB-
cord-349417-vn7q8wc4	70	13	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	70	14	replicase	replicase	NN
cord-349417-vn7q8wc4	70	15	complex	complex	NN
cord-349417-vn7q8wc4	70	16	,	,	,
cord-349417-vn7q8wc4	70	17	it	-PRON-	PRP
cord-349417-vn7q8wc4	70	18	seems	seem	VBZ
cord-349417-vn7q8wc4	70	19	unlikely	unlikely	JJ
cord-349417-vn7q8wc4	70	20	that	that	IN
cord-349417-vn7q8wc4	70	21	the	the	DT
cord-349417-vn7q8wc4	70	22	observed	observed	JJ
cord-349417-vn7q8wc4	70	23	DNA	dna	NN
cord-349417-vn7q8wc4	70	24	duplex	duplex	RB
cord-349417-vn7q8wc4	70	25	-	-	HYPH
cord-349417-vn7q8wc4	70	26	unwinding	unwind	VBG
cord-349417-vn7q8wc4	70	27	activity	activity	NN
cord-349417-vn7q8wc4	70	28	is	be	VBZ
cord-349417-vn7q8wc4	70	29	of	of	IN
cord-349417-vn7q8wc4	70	30	biological	biological	JJ
cord-349417-vn7q8wc4	70	31	significance	significance	NN
cord-349417-vn7q8wc4	70	32	.	.	.
cord-349417-vn7q8wc4	71	1	Coronavirus	Coronavirus	NNP
cord-349417-vn7q8wc4	71	2	helicases	helicase	NNS
cord-349417-vn7q8wc4	71	3	are	be	VBP
cord-349417-vn7q8wc4	71	4	able	able	JJ
cord-349417-vn7q8wc4	71	5	to	to	TO
cord-349417-vn7q8wc4	71	6	unwind	unwind	VB
cord-349417-vn7q8wc4	71	7	up	up	RP
cord-349417-vn7q8wc4	71	8	to	to	IN
cord-349417-vn7q8wc4	71	9	several	several	JJ
cord-349417-vn7q8wc4	71	10	hundred	hundred	CD
cord-349417-vn7q8wc4	71	11	base	base	NN
cord-349417-vn7q8wc4	71	12	pairs	pair	NNS
cord-349417-vn7q8wc4	71	13	of	of	IN
cord-349417-vn7q8wc4	71	14	double	double	RB
cord-349417-vn7q8wc4	71	15	-	-	HYPH
cord-349417-vn7q8wc4	71	16	stranded	strand	VBN
cord-349417-vn7q8wc4	71	17	nucleic	nucleic	JJ
cord-349417-vn7q8wc4	71	18	acid	acid	NN
cord-349417-vn7q8wc4	71	19	in	in	IN
cord-349417-vn7q8wc4	71	20	a	a	DT
cord-349417-vn7q8wc4	71	21	processive	processive	JJ
cord-349417-vn7q8wc4	71	22	manner	manner	NN
cord-349417-vn7q8wc4	71	23	,	,	,
cord-349417-vn7q8wc4	71	24	47,48	47,48	CD
cord-349417-vn7q8wc4	71	25	supporting	support	VBG
cord-349417-vn7q8wc4	71	26	a	a	DT
cord-349417-vn7q8wc4	71	27	role	role	NN
cord-349417-vn7q8wc4	71	28	as	as	IN
cord-349417-vn7q8wc4	71	29	a	a	DT
cord-349417-vn7q8wc4	71	30	"	"	``
cord-349417-vn7q8wc4	71	31	replicative	replicative	JJ
cord-349417-vn7q8wc4	71	32	"	"	''
cord-349417-vn7q8wc4	71	33	helicase	helicase	NN
cord-349417-vn7q8wc4	71	34	that	that	WDT
cord-349417-vn7q8wc4	71	35	separates	separate	VBZ
cord-349417-vn7q8wc4	71	36	regions	region	NNS
cord-349417-vn7q8wc4	71	37	of	of	IN
cord-349417-vn7q8wc4	71	38	doublestranded	doublestranded	NNP
cord-349417-vn7q8wc4	71	39	RNA	RNA	NNP
cord-349417-vn7q8wc4	71	40	that	that	IN
cord-349417-vn7q8wc4	71	41	the	the	DT
cord-349417-vn7q8wc4	71	42	polymerase	polymerase	NN
cord-349417-vn7q8wc4	71	43	might	may	MD
cord-349417-vn7q8wc4	71	44	encounter	encounter	VB
cord-349417-vn7q8wc4	71	45	during	during	IN
cord-349417-vn7q8wc4	71	46	RNA	RNA	NNP
cord-349417-vn7q8wc4	71	47	synthesis	synthesis	NN
cord-349417-vn7q8wc4	71	48	.	.	.
cord-349417-vn7q8wc4	72	1	Coronavirus	Coronavirus	NNP
cord-349417-vn7q8wc4	72	2	helicases	helicase	NNS
cord-349417-vn7q8wc4	72	3	are	be	VBP
cord-349417-vn7q8wc4	72	4	able	able	JJ
cord-349417-vn7q8wc4	72	5	to	to	TO
cord-349417-vn7q8wc4	72	6	hydrolyze	hydrolyze	VB
cord-349417-vn7q8wc4	72	7	essentially	essentially	RB
cord-349417-vn7q8wc4	72	8	all	all	DT
cord-349417-vn7q8wc4	72	9	natural	natural	JJ
cord-349417-vn7q8wc4	72	10	nucleotides	nucleotide	NNS
cord-349417-vn7q8wc4	72	11	to	to	TO
cord-349417-vn7q8wc4	72	12	fuel	fuel	VB
cord-349417-vn7q8wc4	72	13	their	-PRON-	PRP$
cord-349417-vn7q8wc4	72	14	translocation	translocation	NN
cord-349417-vn7q8wc4	72	15	along	along	IN
cord-349417-vn7q8wc4	72	16	nucleic	nucleic	JJ
cord-349417-vn7q8wc4	72	17	acids	acid	NNS
cord-349417-vn7q8wc4	72	18	and	and	CC
cord-349417-vn7q8wc4	72	19	concomitant	concomitant	JJ
cord-349417-vn7q8wc4	72	20	unwinding	unwinding	NN
cord-349417-vn7q8wc4	72	21	of	of	IN
cord-349417-vn7q8wc4	72	22	duplex	duplex	NN
cord-349417-vn7q8wc4	72	23	RNA	RNA	NNP
cord-349417-vn7q8wc4	72	24	(	(	-LRB-
cord-349417-vn7q8wc4	72	25	and	and	CC
cord-349417-vn7q8wc4	72	26	DNA	DNA	NNP
cord-349417-vn7q8wc4	72	27	)	)	-RRB-
cord-349417-vn7q8wc4	72	28	structures	structure	NNS
cord-349417-vn7q8wc4	72	29	.	.	.
cord-349417-vn7q8wc4	73	1	[	[	-LRB-
cord-349417-vn7q8wc4	73	2	44	44	CD
cord-349417-vn7q8wc4	73	3	]	]	-RRB-
cord-349417-vn7q8wc4	73	4	[	[	-LRB-
cord-349417-vn7q8wc4	73	5	45	45	CD
cord-349417-vn7q8wc4	73	6	]	]	-RRB-
cord-349417-vn7q8wc4	74	1	[	[	-LRB-
cord-349417-vn7q8wc4	74	2	46	46	CD
cord-349417-vn7q8wc4	74	3	]	]	-RRB-
cord-349417-vn7q8wc4	75	1	[	[	-LRB-
cord-349417-vn7q8wc4	75	2	47	47	CD
cord-349417-vn7q8wc4	75	3	]	]	-RRB-
cord-349417-vn7q8wc4	76	1	[	[	-LRB-
cord-349417-vn7q8wc4	76	2	48	48	CD
cord-349417-vn7q8wc4	76	3	]	]	-RRB-
cord-349417-vn7q8wc4	77	1	Besides	besides	IN
cord-349417-vn7q8wc4	77	2	their	-PRON-	PRP$
cord-349417-vn7q8wc4	77	3	NTPase	NTPase	NNP
cord-349417-vn7q8wc4	77	4	and	and	CC
cord-349417-vn7q8wc4	77	5	dNTPase	dNTPase	NNP
cord-349417-vn7q8wc4	77	6	activities	activity	NNS
cord-349417-vn7q8wc4	77	7	,	,	,
cord-349417-vn7q8wc4	77	8	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	77	9	helicases	helicase	NNS
cord-349417-vn7q8wc4	77	10	were	be	VBD
cord-349417-vn7q8wc4	77	11	shown	show	VBN
cord-349417-vn7q8wc4	77	12	to	to	TO
cord-349417-vn7q8wc4	77	13	possess	possess	VB
cord-349417-vn7q8wc4	77	14	yet	yet	RB
cord-349417-vn7q8wc4	77	15	another	another	DT
cord-349417-vn7q8wc4	77	16	phosphohydrolyase	phosphohydrolyase	NN
cord-349417-vn7q8wc4	77	17	activity	activity	NN
cord-349417-vn7q8wc4	77	18	,	,	,
cord-349417-vn7q8wc4	77	19	namely	namely	RB
cord-349417-vn7q8wc4	77	20	an	an	DT
cord-349417-vn7q8wc4	77	21	RNA	rna	NN
cord-349417-vn7q8wc4	77	22	5'triphosphatase	5'triphosphatase	CD
cord-349417-vn7q8wc4	77	23	activity	activity	NN
cord-349417-vn7q8wc4	77	24	that	that	WDT
cord-349417-vn7q8wc4	77	25	employs	employ	VBZ
cord-349417-vn7q8wc4	77	26	the	the	DT
cord-349417-vn7q8wc4	77	27	active	active	JJ
cord-349417-vn7q8wc4	77	28	site	site	NN
cord-349417-vn7q8wc4	77	29	of	of	IN
cord-349417-vn7q8wc4	77	30	the	the	DT
cord-349417-vn7q8wc4	77	31	(	(	-LRB-
cord-349417-vn7q8wc4	77	32	d)NTPase	d)NTPase	NNP
cord-349417-vn7q8wc4	77	33	activity	activity	NN
cord-349417-vn7q8wc4	77	34	.	.	.
cord-349417-vn7q8wc4	78	1	It	-PRON-	PRP
cord-349417-vn7q8wc4	78	2	is	be	VBZ
cord-349417-vn7q8wc4	78	3	reasonable	reasonable	JJ
cord-349417-vn7q8wc4	78	4	to	to	TO
cord-349417-vn7q8wc4	78	5	believe	believe	VB
cord-349417-vn7q8wc4	78	6	that	that	IN
cord-349417-vn7q8wc4	78	7	the	the	DT
cord-349417-vn7q8wc4	78	8	nsp13-associated	nsp13-associated	JJ
cord-349417-vn7q8wc4	78	9	RNA	RNA	NNP
cord-349417-vn7q8wc4	78	10	5'-triphosphatase	5'-triphosphatase	NNP
cord-349417-vn7q8wc4	78	11	catalyzes	catalyze	VBZ
cord-349417-vn7q8wc4	78	12	the	the	DT
cord-349417-vn7q8wc4	78	13	first	first	JJ
cord-349417-vn7q8wc4	78	14	reaction	reaction	NN
cord-349417-vn7q8wc4	78	15	in	in	IN
cord-349417-vn7q8wc4	78	16	the	the	DT
cord-349417-vn7q8wc4	78	17	synthesis	synthesis	NN
cord-349417-vn7q8wc4	78	18	of	of	IN
cord-349417-vn7q8wc4	78	19	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	78	20	5	5	CD
cord-349417-vn7q8wc4	78	21	'	'	''
cord-349417-vn7q8wc4	78	22	RNA	rna	NN
cord-349417-vn7q8wc4	78	23	cap	cap	NN
cord-349417-vn7q8wc4	78	24	structures	structure	NNS
cord-349417-vn7q8wc4	78	25	.	.	.
cord-349417-vn7q8wc4	79	1	47	47	CD
cord-349417-vn7q8wc4	79	2	,	,	,
cord-349417-vn7q8wc4	79	3	48	48	CD
cord-349417-vn7q8wc4	80	1	Given	give	VBN
cord-349417-vn7q8wc4	80	2	the	the	DT
cord-349417-vn7q8wc4	80	3	multiple	multiple	JJ
cord-349417-vn7q8wc4	80	4	enzymatic	enzymatic	JJ
cord-349417-vn7q8wc4	80	5	activities	activity	NNS
cord-349417-vn7q8wc4	80	6	of	of	IN
cord-349417-vn7q8wc4	80	7	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	80	8	helicases	helicase	NNS
cord-349417-vn7q8wc4	80	9	and	and	CC
cord-349417-vn7q8wc4	80	10	the	the	DT
cord-349417-vn7q8wc4	80	11	previously	previously	RB
cord-349417-vn7q8wc4	80	12	observed	observe	VBN
cord-349417-vn7q8wc4	80	13	diverse	diverse	JJ
cord-349417-vn7q8wc4	80	14	roles	role	NNS
cord-349417-vn7q8wc4	80	15	of	of	IN
cord-349417-vn7q8wc4	80	16	the	the	DT
cord-349417-vn7q8wc4	80	17	arterivirus	arterivirus	NNP
cord-349417-vn7q8wc4	80	18	helicase	helicase	NNP
cord-349417-vn7q8wc4	80	19	in	in	IN
cord-349417-vn7q8wc4	80	20	viral	viral	JJ
cord-349417-vn7q8wc4	80	21	replication	replication	NN
cord-349417-vn7q8wc4	80	22	,	,	,
cord-349417-vn7q8wc4	80	23	transcription	transcription	NN
cord-349417-vn7q8wc4	80	24	and	and	CC
cord-349417-vn7q8wc4	80	25	virion	virion	NN
cord-349417-vn7q8wc4	80	26	biogenesis	biogenesis	NN
cord-349417-vn7q8wc4	80	27	,	,	,
cord-349417-vn7q8wc4	80	28	52	52	CD
cord-349417-vn7q8wc4	80	29	it	-PRON-	PRP
cord-349417-vn7q8wc4	80	30	is	be	VBZ
cord-349417-vn7q8wc4	80	31	reasonable	reasonable	JJ
cord-349417-vn7q8wc4	80	32	to	to	TO
cord-349417-vn7q8wc4	80	33	believe	believe	VB
cord-349417-vn7q8wc4	80	34	that	that	IN
cord-349417-vn7q8wc4	80	35	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	80	36	helicases	helicase	NNS
cord-349417-vn7q8wc4	80	37	are	be	VBP
cord-349417-vn7q8wc4	80	38	involved	involve	VBN
cord-349417-vn7q8wc4	80	39	in	in	IN
cord-349417-vn7q8wc4	80	40	more	more	JJR
cord-349417-vn7q8wc4	80	41	than	than	IN
cord-349417-vn7q8wc4	80	42	one	one	CD
cord-349417-vn7q8wc4	80	43	metabolic	metabolic	JJ
cord-349417-vn7q8wc4	80	44	pathway	pathway	NN
cord-349417-vn7q8wc4	80	45	in	in	IN
cord-349417-vn7q8wc4	80	46	the	the	DT
cord-349417-vn7q8wc4	80	47	viral	viral	JJ
cord-349417-vn7q8wc4	80	48	life	life	NN
cord-349417-vn7q8wc4	80	49	cycle	cycle	NN
cord-349417-vn7q8wc4	80	50	.	.	.
cord-349417-vn7q8wc4	81	1	A	a	DT
cord-349417-vn7q8wc4	81	2	detailed	detailed	JJ
cord-349417-vn7q8wc4	81	3	sequence	sequence	NN
cord-349417-vn7q8wc4	81	4	analysis	analysis	NN
cord-349417-vn7q8wc4	81	5	by	by	IN
cord-349417-vn7q8wc4	81	6	Gorbalenya	Gorbalenya	NNP
cord-349417-vn7q8wc4	81	7	,	,	,
cord-349417-vn7q8wc4	81	8	Snijder	Snijder	NNP
cord-349417-vn7q8wc4	81	9	and	and	CC
cord-349417-vn7q8wc4	81	10	colleagues	colleague	NNS
cord-349417-vn7q8wc4	81	11	of	of	IN
cord-349417-vn7q8wc4	81	12	the	the	DT
cord-349417-vn7q8wc4	81	13	SARS	SARS	NNP
cord-349417-vn7q8wc4	81	14	-	-	HYPH
cord-349417-vn7q8wc4	81	15	CoV	CoV	NNP
cord-349417-vn7q8wc4	81	16	genome	genome	NN
cord-349417-vn7q8wc4	81	17	revealed	reveal	VBD
cord-349417-vn7q8wc4	81	18	that	that	IN
cord-349417-vn7q8wc4	81	19	the	the	DT
cord-349417-vn7q8wc4	81	20	enzymology	enzymology	NN
cord-349417-vn7q8wc4	81	21	of	of	IN
cord-349417-vn7q8wc4	81	22	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	81	23	RNA	RNA	NNP
cord-349417-vn7q8wc4	81	24	synthesis	synthesis	NN
cord-349417-vn7q8wc4	81	25	may	may	MD
cord-349417-vn7q8wc4	81	26	be	be	VB
cord-349417-vn7q8wc4	81	27	significantly	significantly	RB
cord-349417-vn7q8wc4	81	28	more	more	RBR
cord-349417-vn7q8wc4	81	29	complex	complex	JJ
cord-349417-vn7q8wc4	81	30	than	than	IN
cord-349417-vn7q8wc4	81	31	previously	previously	RB
cord-349417-vn7q8wc4	81	32	thought	think	VBN
cord-349417-vn7q8wc4	81	33	.	.	.
cord-349417-vn7q8wc4	82	1	8	8	CD
cord-349417-vn7q8wc4	83	1	In	in	IN
cord-349417-vn7q8wc4	83	2	this	this	DT
cord-349417-vn7q8wc4	83	3	seminal	seminal	JJ
cord-349417-vn7q8wc4	83	4	study	study	NN
cord-349417-vn7q8wc4	83	5	published	publish	VBN
cord-349417-vn7q8wc4	83	6	in	in	IN
cord-349417-vn7q8wc4	83	7	2003	2003	CD
cord-349417-vn7q8wc4	83	8	,	,	,
cord-349417-vn7q8wc4	83	9	as	as	RB
cord-349417-vn7q8wc4	83	10	many	many	JJ
cord-349417-vn7q8wc4	83	11	as	as	IN
cord-349417-vn7q8wc4	83	12	five	five	CD
cord-349417-vn7q8wc4	83	13	novel	novel	JJ
cord-349417-vn7q8wc4	83	14	enzymatic	enzymatic	JJ
cord-349417-vn7q8wc4	83	15	activities	activity	NNS
cord-349417-vn7q8wc4	83	16	were	be	VBD
cord-349417-vn7q8wc4	83	17	identified	identify	VBN
cord-349417-vn7q8wc4	83	18	in	in	IN
cord-349417-vn7q8wc4	83	19	the	the	DT
cord-349417-vn7q8wc4	83	20	genomes	genome	NNS
cord-349417-vn7q8wc4	83	21	of	of	IN
cord-349417-vn7q8wc4	83	22	coronaviruses	coronaviruse	NNS
cord-349417-vn7q8wc4	83	23	and	and	CC
cord-349417-vn7q8wc4	83	24	,	,	,
cord-349417-vn7q8wc4	83	25	to	to	IN
cord-349417-vn7q8wc4	83	26	a	a	DT
cord-349417-vn7q8wc4	83	27	varying	varying	JJ
cord-349417-vn7q8wc4	83	28	extent	extent	NN
cord-349417-vn7q8wc4	83	29	,	,	,
cord-349417-vn7q8wc4	83	30	other	other	JJ
cord-349417-vn7q8wc4	83	31	nidoviruses	nidoviruse	NNS
cord-349417-vn7q8wc4	83	32	(	(	-LRB-
cord-349417-vn7q8wc4	83	33	Fig	fig	NN
cord-349417-vn7q8wc4	83	34	.	.	.
cord-349417-vn7q8wc4	83	35	1	1	CD
cord-349417-vn7q8wc4	83	36	)	)	-RRB-
cord-349417-vn7q8wc4	83	37	.	.	.
cord-349417-vn7q8wc4	84	1	The	the	DT
cord-349417-vn7q8wc4	84	2	putative	putative	JJ
cord-349417-vn7q8wc4	84	3	activities	activity	NNS
cord-349417-vn7q8wc4	84	4	included	include	VBD
cord-349417-vn7q8wc4	84	5	(	(	-LRB-
cord-349417-vn7q8wc4	84	6	i	i	NN
cord-349417-vn7q8wc4	84	7	)	)	-RRB-
cord-349417-vn7q8wc4	84	8	a	a	DT
cord-349417-vn7q8wc4	84	9	3'-to-5	3'-to-5	CD
cord-349417-vn7q8wc4	84	10	'	'	''
cord-349417-vn7q8wc4	84	11	exonuclease	exonuclease	NN
cord-349417-vn7q8wc4	84	12	(	(	-LRB-
cord-349417-vn7q8wc4	84	13	ExoN	ExoN	NNP
cord-349417-vn7q8wc4	84	14	)	)	-RRB-
cord-349417-vn7q8wc4	84	15	associated	associate	VBN
cord-349417-vn7q8wc4	84	16	with	with	IN
cord-349417-vn7q8wc4	84	17	nsp14	nsp14	NNP
cord-349417-vn7q8wc4	84	18	,	,	,
cord-349417-vn7q8wc4	84	19	(	(	-LRB-
cord-349417-vn7q8wc4	84	20	ii	ii	NN
cord-349417-vn7q8wc4	84	21	)	)	-RRB-
cord-349417-vn7q8wc4	85	1	an	an	DT
cord-349417-vn7q8wc4	85	2	endoribonuclease	endoribonuclease	NN
cord-349417-vn7q8wc4	85	3	(	(	-LRB-
cord-349417-vn7q8wc4	85	4	NendoU	NendoU	NNP
cord-349417-vn7q8wc4	85	5	)	)	-RRB-
cord-349417-vn7q8wc4	85	6	associated	associate	VBN
cord-349417-vn7q8wc4	85	7	with	with	IN
cord-349417-vn7q8wc4	85	8	nsp15	nsp15	NNP
cord-349417-vn7q8wc4	85	9	,	,	,
cord-349417-vn7q8wc4	85	10	(	(	-LRB-
cord-349417-vn7q8wc4	85	11	iii	iii	NN
cord-349417-vn7q8wc4	85	12	)	)	-RRB-
cord-349417-vn7q8wc4	85	13	an	an	DT
cord-349417-vn7q8wc4	85	14	S	S	NNP
cord-349417-vn7q8wc4	85	15	-	-	HYPH
cord-349417-vn7q8wc4	85	16	adenosyl	adenosyl	NN
cord-349417-vn7q8wc4	85	17	methionine	methionine	NN
cord-349417-vn7q8wc4	85	18	-	-	HYPH
cord-349417-vn7q8wc4	85	19	dependent	dependent	JJ
cord-349417-vn7q8wc4	85	20	ribose	ribose	NN
cord-349417-vn7q8wc4	86	1	2'-Omethyltransferase	2'-omethyltransferase	LS
cord-349417-vn7q8wc4	87	1	(	(	-LRB-
cord-349417-vn7q8wc4	87	2	MT	MT	NNP
cord-349417-vn7q8wc4	87	3	)	)	-RRB-
cord-349417-vn7q8wc4	88	1	associated	associate	VBN
cord-349417-vn7q8wc4	88	2	with	with	IN
cord-349417-vn7q8wc4	88	3	nsp16	nsp16	NNS
cord-349417-vn7q8wc4	88	4	,	,	,
cord-349417-vn7q8wc4	88	5	(	(	-LRB-
cord-349417-vn7q8wc4	88	6	iv	iv	LS
cord-349417-vn7q8wc4	88	7	)	)	-RRB-
cord-349417-vn7q8wc4	89	1	an	an	DT
cord-349417-vn7q8wc4	89	2	ADP	ADP	NNP
cord-349417-vn7q8wc4	89	3	-	-	HYPH
cord-349417-vn7q8wc4	89	4	ribose	ribose	NN
cord-349417-vn7q8wc4	89	5	1"-phosphatase	1"-phosphatase	CD
cord-349417-vn7q8wc4	90	1	(	(	-LRB-
cord-349417-vn7q8wc4	90	2	Appr-1"-pase	appr-1"-pase	NN
cord-349417-vn7q8wc4	90	3	)	)	-RRB-
cord-349417-vn7q8wc4	91	1	associated	associate	VBN
cord-349417-vn7q8wc4	91	2	with	with	IN
cord-349417-vn7q8wc4	91	3	the	the	DT
cord-349417-vn7q8wc4	91	4	so	so	RB
cord-349417-vn7q8wc4	91	5	-	-	HYPH
cord-349417-vn7q8wc4	91	6	called	call	VBN
cord-349417-vn7q8wc4	91	7	"	"	``
cord-349417-vn7q8wc4	91	8	X	x	NN
cord-349417-vn7q8wc4	91	9	domain	domain	NN
cord-349417-vn7q8wc4	91	10	"	"	''
cord-349417-vn7q8wc4	91	11	of	of	IN
cord-349417-vn7q8wc4	91	12	nsp3	nsp3	NNS
cord-349417-vn7q8wc4	91	13	,	,	,
cord-349417-vn7q8wc4	91	14	and	and	CC
cord-349417-vn7q8wc4	91	15	(	(	-LRB-
cord-349417-vn7q8wc4	91	16	v	v	LS
cord-349417-vn7q8wc4	91	17	)	)	-RRB-
cord-349417-vn7q8wc4	91	18	a	a	DT
cord-349417-vn7q8wc4	91	19	cyclic	cyclic	JJ
cord-349417-vn7q8wc4	91	20	phosphodiesterase	phosphodiesterase	NN
cord-349417-vn7q8wc4	91	21	(	(	-LRB-
cord-349417-vn7q8wc4	91	22	CPDase	CPDase	NNP
cord-349417-vn7q8wc4	91	23	)	)	-RRB-
cord-349417-vn7q8wc4	91	24	,	,	,
cord-349417-vn7q8wc4	91	25	which	which	WDT
cord-349417-vn7q8wc4	91	26	is	be	VBZ
cord-349417-vn7q8wc4	91	27	only	only	RB
cord-349417-vn7q8wc4	91	28	conserved	conserve	VBN
cord-349417-vn7q8wc4	91	29	in	in	IN
cord-349417-vn7q8wc4	91	30	group	group	NN
cord-349417-vn7q8wc4	91	31	II	II	NNP
cord-349417-vn7q8wc4	91	32	coronaviruses	coronaviruse	NNS
cord-349417-vn7q8wc4	91	33	(	(	-LRB-
cord-349417-vn7q8wc4	91	34	excluding	exclude	VBG
cord-349417-vn7q8wc4	91	35	SARS	SARS	NNP
cord-349417-vn7q8wc4	91	36	-	-	HYPH
cord-349417-vn7q8wc4	91	37	CoV	CoV	NNP
cord-349417-vn7q8wc4	91	38	)	)	-RRB-
cord-349417-vn7q8wc4	91	39	.	.	.
cord-349417-vn7q8wc4	92	1	Four	four	CD
cord-349417-vn7q8wc4	92	2	of	of	IN
cord-349417-vn7q8wc4	92	3	the	the	DT
cord-349417-vn7q8wc4	92	4	activities	activity	NNS
cord-349417-vn7q8wc4	92	5	were	be	VBD
cord-349417-vn7q8wc4	92	6	found	find	VBN
cord-349417-vn7q8wc4	92	7	to	to	TO
cord-349417-vn7q8wc4	92	8	be	be	VB
cord-349417-vn7q8wc4	92	9	conserved	conserve	VBN
cord-349417-vn7q8wc4	92	10	in	in	IN
cord-349417-vn7q8wc4	92	11	all	all	DT
cord-349417-vn7q8wc4	92	12	coronaviruses	coronaviruse	NNS
cord-349417-vn7q8wc4	92	13	,	,	,
cord-349417-vn7q8wc4	92	14	suggesting	suggest	VBG
cord-349417-vn7q8wc4	92	15	that	that	IN
cord-349417-vn7q8wc4	92	16	they	-PRON-	PRP
cord-349417-vn7q8wc4	92	17	have	have	VBP
cord-349417-vn7q8wc4	92	18	an	an	DT
cord-349417-vn7q8wc4	92	19	essential	essential	JJ
cord-349417-vn7q8wc4	92	20	role	role	NN
cord-349417-vn7q8wc4	92	21	in	in	IN
cord-349417-vn7q8wc4	92	22	the	the	DT
cord-349417-vn7q8wc4	92	23	coronaviral	coronaviral	JJ
cord-349417-vn7q8wc4	92	24	life	life	NN
cord-349417-vn7q8wc4	92	25	cycle	cycle	NN
cord-349417-vn7q8wc4	92	26	.	.	.
cord-349417-vn7q8wc4	93	1	Recently	recently	RB
cord-349417-vn7q8wc4	93	2	,	,	,
cord-349417-vn7q8wc4	93	3	the	the	DT
cord-349417-vn7q8wc4	93	4	predicted	predict	VBN
cord-349417-vn7q8wc4	93	5	exo	exo	NNP
cord-349417-vn7q8wc4	93	6	-	-	HYPH
cord-349417-vn7q8wc4	93	7	and	and	CC
cord-349417-vn7q8wc4	93	8	endoribonuclease	endoribonuclease	NN
cord-349417-vn7q8wc4	93	9	activities	activity	NNS
cord-349417-vn7q8wc4	93	10	were	be	VBD
cord-349417-vn7q8wc4	93	11	established	establish	VBN
cord-349417-vn7q8wc4	93	12	and	and	CC
cord-349417-vn7q8wc4	93	13	characterized	characterize	VBN
cord-349417-vn7q8wc4	93	14	using	use	VBG
cord-349417-vn7q8wc4	93	15	bacterially	bacterially	RB
cord-349417-vn7q8wc4	93	16	expressed	express	VBN
cord-349417-vn7q8wc4	93	17	forms	form	NNS
cord-349417-vn7q8wc4	93	18	of	of	IN
cord-349417-vn7q8wc4	93	19	the	the	DT
cord-349417-vn7q8wc4	93	20	ExoN	ExoN	NNP
cord-349417-vn7q8wc4	93	21	from	from	IN
cord-349417-vn7q8wc4	93	22	SARS	SARS	NNP
cord-349417-vn7q8wc4	93	23	-	-	HYPH
cord-349417-vn7q8wc4	93	24	CoV	CoV	NNP
cord-349417-vn7q8wc4	93	25	(	(	-LRB-
cord-349417-vn7q8wc4	93	26	Minskaia	Minskaia	NNP
cord-349417-vn7q8wc4	93	27	,	,	,
cord-349417-vn7q8wc4	93	28	Hertzig	Hertzig	NNP
cord-349417-vn7q8wc4	93	29	,	,	,
cord-349417-vn7q8wc4	93	30	Gorbalenya	Gorbalenya	NNP
cord-349417-vn7q8wc4	93	31	,	,	,
cord-349417-vn7q8wc4	93	32	Campanacci	Campanacci	NNP
cord-349417-vn7q8wc4	93	33	,	,	,
cord-349417-vn7q8wc4	93	34	Cambillau	Cambillau	NNP
cord-349417-vn7q8wc4	93	35	,	,	,
cord-349417-vn7q8wc4	93	36	Canard	Canard	NNP
cord-349417-vn7q8wc4	93	37	,	,	,
cord-349417-vn7q8wc4	93	38	and	and	CC
cord-349417-vn7q8wc4	93	39	Ziebuhr	Ziebuhr	NNP
cord-349417-vn7q8wc4	93	40	,	,	,
cord-349417-vn7q8wc4	93	41	unpublished	unpublished	JJ
cord-349417-vn7q8wc4	93	42	data	datum	NNS
cord-349417-vn7q8wc4	93	43	)	)	-RRB-
cord-349417-vn7q8wc4	93	44	,	,	,
cord-349417-vn7q8wc4	93	45	and	and	CC
cord-349417-vn7q8wc4	93	46	the	the	DT
cord-349417-vn7q8wc4	93	47	NendoU	NendoU	NNP
cord-349417-vn7q8wc4	93	48	from	from	IN
cord-349417-vn7q8wc4	93	49	HCoV-229E	HCoV-229E	NNP
cord-349417-vn7q8wc4	93	50	,	,	,
cord-349417-vn7q8wc4	93	51	SARS	SARS	NNP
cord-349417-vn7q8wc4	93	52	-	-	HYPH
cord-349417-vn7q8wc4	93	53	CoV	CoV	NNP
cord-349417-vn7q8wc4	93	54	,	,	,
cord-349417-vn7q8wc4	93	55	and	and	CC
cord-349417-vn7q8wc4	93	56	IBV	IBV	NNP
cord-349417-vn7q8wc4	93	57	.	.	.
cord-349417-vn7q8wc4	94	1	53	53	CD
cord-349417-vn7q8wc4	94	2	,	,	,
cord-349417-vn7q8wc4	94	3	54	54	CD
cord-349417-vn7q8wc4	95	1	We	-PRON-	PRP
cord-349417-vn7q8wc4	95	2	have	have	VBP
cord-349417-vn7q8wc4	95	3	recently	recently	RB
cord-349417-vn7q8wc4	95	4	demonstrated	demonstrate	VBN
cord-349417-vn7q8wc4	95	5	by	by	IN
cord-349417-vn7q8wc4	95	6	reverse	reverse	JJ
cord-349417-vn7q8wc4	95	7	genetics	genetic	NNS
cord-349417-vn7q8wc4	95	8	using	use	VBG
cord-349417-vn7q8wc4	95	9	the	the	DT
cord-349417-vn7q8wc4	95	10	HCoV-229E	HCoV-229E	NNP
cord-349417-vn7q8wc4	95	11	infectious	infectious	JJ
cord-349417-vn7q8wc4	95	12	clone	clone	NN
cord-349417-vn7q8wc4	95	13	that	that	IN
cord-349417-vn7q8wc4	95	14	the	the	DT
cord-349417-vn7q8wc4	95	15	ExoN	ExoN	NNP
cord-349417-vn7q8wc4	95	16	,	,	,
cord-349417-vn7q8wc4	95	17	NendoU	NendoU	NNP
cord-349417-vn7q8wc4	95	18	,	,	,
cord-349417-vn7q8wc4	95	19	and	and	CC
cord-349417-vn7q8wc4	95	20	MT	MT	NNP
cord-349417-vn7q8wc4	95	21	domains	domain	NNS
cord-349417-vn7q8wc4	95	22	are	be	VBP
cord-349417-vn7q8wc4	95	23	all	all	RB
cord-349417-vn7q8wc4	95	24	essential	essential	JJ
cord-349417-vn7q8wc4	95	25	for	for	IN
cord-349417-vn7q8wc4	95	26	the	the	DT
cord-349417-vn7q8wc4	95	27	production	production	NN
cord-349417-vn7q8wc4	95	28	of	of	IN
cord-349417-vn7q8wc4	95	29	virus	virus	NN
cord-349417-vn7q8wc4	95	30	progeny	progeny	NN
cord-349417-vn7q8wc4	95	31	.	.	.
cord-349417-vn7q8wc4	96	1	Substitutions	substitution	NNS
cord-349417-vn7q8wc4	96	2	of	of	IN
cord-349417-vn7q8wc4	96	3	predicted	predict	VBN
cord-349417-vn7q8wc4	96	4	active	active	JJ
cord-349417-vn7q8wc4	96	5	-	-	HYPH
cord-349417-vn7q8wc4	96	6	site	site	NN
cord-349417-vn7q8wc4	96	7	residues	residue	NNS
cord-349417-vn7q8wc4	96	8	resulted	result	VBD
cord-349417-vn7q8wc4	96	9	in	in	IN
cord-349417-vn7q8wc4	96	10	diverse	diverse	JJ
cord-349417-vn7q8wc4	96	11	defects	defect	NNS
cord-349417-vn7q8wc4	96	12	in	in	IN
cord-349417-vn7q8wc4	96	13	viral	viral	JJ
cord-349417-vn7q8wc4	96	14	RNA	RNA	NNP
cord-349417-vn7q8wc4	96	15	synthesis	synthesis	NN
cord-349417-vn7q8wc4	96	16	and	and	CC
cord-349417-vn7q8wc4	96	17	virus	virus	NN
cord-349417-vn7q8wc4	96	18	production	production	NN
cord-349417-vn7q8wc4	96	19	54	54	CD
cord-349417-vn7q8wc4	97	1	(	(	-LRB-
cord-349417-vn7q8wc4	97	2	Hertzig	Hertzig	NNP
cord-349417-vn7q8wc4	97	3	,	,	,
cord-349417-vn7q8wc4	97	4	Ulferts	Ulferts	NNP
cord-349417-vn7q8wc4	97	5	,	,	,
cord-349417-vn7q8wc4	97	6	Schelle	Schelle	NNP
cord-349417-vn7q8wc4	97	7	,	,	,
cord-349417-vn7q8wc4	97	8	and	and	CC
cord-349417-vn7q8wc4	97	9	Ziebuhr	Ziebuhr	NNP
cord-349417-vn7q8wc4	97	10	,	,	,
cord-349417-vn7q8wc4	97	11	unpublished	unpublished	JJ
cord-349417-vn7q8wc4	97	12	data	datum	NNS
cord-349417-vn7q8wc4	97	13	)	)	-RRB-
cord-349417-vn7q8wc4	97	14	.	.	.
cord-349417-vn7q8wc4	98	1	The	the	DT
cord-349417-vn7q8wc4	98	2	underlying	underlie	VBG
cord-349417-vn7q8wc4	98	3	mechanisms	mechanism	NNS
cord-349417-vn7q8wc4	98	4	for	for	IN
cord-349417-vn7q8wc4	98	5	the	the	DT
cord-349417-vn7q8wc4	98	6	observed	observed	JJ
cord-349417-vn7q8wc4	98	7	defects	defect	NNS
cord-349417-vn7q8wc4	98	8	are	be	VBP
cord-349417-vn7q8wc4	98	9	currently	currently	RB
cord-349417-vn7q8wc4	98	10	being	be	VBG
cord-349417-vn7q8wc4	98	11	studied	study	VBN
cord-349417-vn7q8wc4	98	12	in	in	IN
cord-349417-vn7q8wc4	98	13	detail	detail	NN
cord-349417-vn7q8wc4	98	14	.	.	.
cord-349417-vn7q8wc4	99	1	The	the	DT
cord-349417-vn7q8wc4	99	2	observed	observed	JJ
cord-349417-vn7q8wc4	99	3	pattern	pattern	NN
cord-349417-vn7q8wc4	99	4	of	of	IN
cord-349417-vn7q8wc4	99	5	conservation	conservation	NN
cord-349417-vn7q8wc4	99	6	in	in	IN
cord-349417-vn7q8wc4	99	7	different	different	JJ
cord-349417-vn7q8wc4	99	8	nidovirus	nidovirus	NNP
cord-349417-vn7q8wc4	99	9	families	family	NNS
cord-349417-vn7q8wc4	99	10	suggests	suggest	VBZ
cord-349417-vn7q8wc4	99	11	a	a	DT
cord-349417-vn7q8wc4	99	12	functional	functional	JJ
cord-349417-vn7q8wc4	99	13	hierarchy	hierarchy	NN
cord-349417-vn7q8wc4	99	14	for	for	IN
cord-349417-vn7q8wc4	99	15	the	the	DT
cord-349417-vn7q8wc4	99	16	newly	newly	RB
cord-349417-vn7q8wc4	99	17	identified	identify	VBN
cord-349417-vn7q8wc4	99	18	RNA	rna	NN
cord-349417-vn7q8wc4	99	19	-	-	HYPH
cord-349417-vn7q8wc4	99	20	processing	process	VBG
cord-349417-vn7q8wc4	99	21	activities	activity	NNS
cord-349417-vn7q8wc4	99	22	,	,	,
cord-349417-vn7q8wc4	99	23	with	with	IN
cord-349417-vn7q8wc4	99	24	the	the	DT
cord-349417-vn7q8wc4	99	25	manganese	manganese	NN
cord-349417-vn7q8wc4	99	26	ion	ion	NN
cord-349417-vn7q8wc4	99	27	-	-	HYPH
cord-349417-vn7q8wc4	99	28	dependent	dependent	JJ
cord-349417-vn7q8wc4	99	29	uridylate	uridylate	JJ
cord-349417-vn7q8wc4	99	30	-	-	HYPH
cord-349417-vn7q8wc4	99	31	specific	specific	JJ
cord-349417-vn7q8wc4	99	32	endoribonuclease	endoribonuclease	NN
cord-349417-vn7q8wc4	99	33	,	,	,
cord-349417-vn7q8wc4	99	34	NendoU	NendoU	NNP
cord-349417-vn7q8wc4	99	35	,	,	,
cord-349417-vn7q8wc4	99	36	playing	play	VBG
cord-349417-vn7q8wc4	99	37	a	a	DT
cord-349417-vn7q8wc4	99	38	central	central	JJ
cord-349417-vn7q8wc4	99	39	role	role	NN
cord-349417-vn7q8wc4	99	40	.	.	.
cord-349417-vn7q8wc4	100	1	This	this	DT
cord-349417-vn7q8wc4	100	2	enzyme	enzyme	NN
cord-349417-vn7q8wc4	100	3	is	be	VBZ
cord-349417-vn7q8wc4	100	4	universally	universally	RB
cord-349417-vn7q8wc4	100	5	conserved	conserve	VBN
cord-349417-vn7q8wc4	100	6	in	in	IN
cord-349417-vn7q8wc4	100	7	nidoviruses	nidoviruse	NNS
cord-349417-vn7q8wc4	100	8	and	and	CC
cord-349417-vn7q8wc4	100	9	,	,	,
cord-349417-vn7q8wc4	100	10	besides	besides	IN
cord-349417-vn7q8wc4	100	11	the	the	DT
cord-349417-vn7q8wc4	100	12	ZBDassociated	ZBDassociated	NNP
cord-349417-vn7q8wc4	100	13	helicase	helicase	NN
cord-349417-vn7q8wc4	100	14	,	,	,
cord-349417-vn7q8wc4	100	15	represents	represent	VBZ
cord-349417-vn7q8wc4	100	16	a	a	DT
cord-349417-vn7q8wc4	100	17	genetic	genetic	JJ
cord-349417-vn7q8wc4	100	18	marker	marker	NN
cord-349417-vn7q8wc4	100	19	of	of	IN
cord-349417-vn7q8wc4	100	20	nidoviruses	nidoviruse	NNS
cord-349417-vn7q8wc4	100	21	that	that	WDT
cord-349417-vn7q8wc4	100	22	is	be	VBZ
cord-349417-vn7q8wc4	100	23	also	also	RB
cord-349417-vn7q8wc4	100	24	reflected	reflect	VBN
cord-349417-vn7q8wc4	100	25	by	by	IN
cord-349417-vn7q8wc4	100	26	its	-PRON-	PRP$
cord-349417-vn7q8wc4	100	27	previous	previous	JJ
cord-349417-vn7q8wc4	100	28	designation	designation	NN
cord-349417-vn7q8wc4	100	29	as	as	IN
cord-349417-vn7q8wc4	100	30	"	"	``
cord-349417-vn7q8wc4	100	31	nidovirus	nidovirus	NN
cord-349417-vn7q8wc4	100	32	-	-	HYPH
cord-349417-vn7q8wc4	100	33	specific	specific	JJ
cord-349417-vn7q8wc4	100	34	conserved	conserved	JJ
cord-349417-vn7q8wc4	100	35	domain	domain	NN
cord-349417-vn7q8wc4	100	36	"	"	''
cord-349417-vn7q8wc4	100	37	55	55	CD
cord-349417-vn7q8wc4	100	38	,	,	,
cord-349417-vn7q8wc4	100	39	56	56	CD
cord-349417-vn7q8wc4	100	40	.	.	.
cord-349417-vn7q8wc4	101	1	As	as	IN
cord-349417-vn7q8wc4	101	2	mentioned	mention	VBN
cord-349417-vn7q8wc4	101	3	above	above	RB
cord-349417-vn7q8wc4	101	4	,	,	,
cord-349417-vn7q8wc4	101	5	NendoU	NendoU	NNP
cord-349417-vn7q8wc4	101	6	has	have	VBZ
cord-349417-vn7q8wc4	101	7	been	be	VBN
cord-349417-vn7q8wc4	101	8	demonstrated	demonstrate	VBN
cord-349417-vn7q8wc4	101	9	by	by	IN
cord-349417-vn7q8wc4	101	10	site	site	NN
cord-349417-vn7q8wc4	101	11	-	-	HYPH
cord-349417-vn7q8wc4	101	12	directed	direct	VBN
cord-349417-vn7q8wc4	101	13	mutagenesis	mutagenesis	NN
cord-349417-vn7q8wc4	101	14	of	of	IN
cord-349417-vn7q8wc4	101	15	the	the	DT
cord-349417-vn7q8wc4	101	16	full	full	JJ
cord-349417-vn7q8wc4	101	17	-	-	HYPH
cord-349417-vn7q8wc4	101	18	length	length	NN
cord-349417-vn7q8wc4	101	19	HCoV-229E	HCoV-229E	NNP
cord-349417-vn7q8wc4	101	20	clone	clone	NN
cord-349417-vn7q8wc4	101	21	to	to	TO
cord-349417-vn7q8wc4	101	22	be	be	VB
cord-349417-vn7q8wc4	101	23	essential	essential	JJ
cord-349417-vn7q8wc4	101	24	for	for	IN
cord-349417-vn7q8wc4	101	25	coronaviral	coronaviral	NNP
cord-349417-vn7q8wc4	101	26	RNA	RNA	NNP
cord-349417-vn7q8wc4	101	27	synthesis	synthesis	NN
cord-349417-vn7q8wc4	101	28	.	.	.
cord-349417-vn7q8wc4	102	1	However	however	RB
cord-349417-vn7q8wc4	102	2	,	,	,
cord-349417-vn7q8wc4	102	3	we	-PRON-	PRP
cord-349417-vn7q8wc4	102	4	recently	recently	RB
cord-349417-vn7q8wc4	102	5	obtained	obtain	VBD
cord-349417-vn7q8wc4	102	6	mutagenesis	mutagenesis	NN
cord-349417-vn7q8wc4	102	7	data	datum	NNS
cord-349417-vn7q8wc4	102	8	that	that	WDT
cord-349417-vn7q8wc4	102	9	argue	argue	VBP
cord-349417-vn7q8wc4	102	10	for	for	IN
cord-349417-vn7q8wc4	102	11	a	a	DT
cord-349417-vn7q8wc4	102	12	more	more	RBR
cord-349417-vn7q8wc4	102	13	complex	complex	JJ
cord-349417-vn7q8wc4	102	14	scenario	scenario	NN
cord-349417-vn7q8wc4	102	15	regarding	regard	VBG
cord-349417-vn7q8wc4	102	16	the	the	DT
cord-349417-vn7q8wc4	102	17	activities	activity	NNS
cord-349417-vn7q8wc4	102	18	of	of	IN
cord-349417-vn7q8wc4	102	19	NendoU.	NendoU.	NNP
cord-349417-vn7q8wc4	103	1	Thus	thus	RB
cord-349417-vn7q8wc4	103	2	,	,	,
cord-349417-vn7q8wc4	103	3	for	for	IN
cord-349417-vn7q8wc4	103	4	example	example	NN
cord-349417-vn7q8wc4	103	5	,	,	,
cord-349417-vn7q8wc4	103	6	we	-PRON-	PRP
cord-349417-vn7q8wc4	103	7	found	find	VBD
cord-349417-vn7q8wc4	103	8	that	that	IN
cord-349417-vn7q8wc4	103	9	several	several	JJ
cord-349417-vn7q8wc4	103	10	single	single	JJ
cord-349417-vn7q8wc4	103	11	-	-	HYPH
cord-349417-vn7q8wc4	103	12	residue	residue	NN
cord-349417-vn7q8wc4	103	13	substitutions	substitution	NNS
cord-349417-vn7q8wc4	103	14	that	that	WDT
cord-349417-vn7q8wc4	103	15	abolished	abolish	VBD
cord-349417-vn7q8wc4	103	16	the	the	DT
cord-349417-vn7q8wc4	103	17	NendoU	NendoU	NNP
cord-349417-vn7q8wc4	103	18	activity	activity	NN
cord-349417-vn7q8wc4	103	19	in	in	IN
cord-349417-vn7q8wc4	103	20	an	an	DT
cord-349417-vn7q8wc4	103	21	in	in	FW
cord-349417-vn7q8wc4	103	22	vitro	vitro	FW
cord-349417-vn7q8wc4	103	23	RNase	rnase	NN
cord-349417-vn7q8wc4	103	24	assay	assay	NN
cord-349417-vn7q8wc4	103	25	gave	give	VBD
cord-349417-vn7q8wc4	103	26	rise	rise	NN
cord-349417-vn7q8wc4	103	27	to	to	IN
cord-349417-vn7q8wc4	103	28	viable	viable	JJ
cord-349417-vn7q8wc4	103	29	(	(	-LRB-
cord-349417-vn7q8wc4	103	30	albeit	albeit	IN
cord-349417-vn7q8wc4	103	31	lowtiter	lowtiter	NNP
cord-349417-vn7q8wc4	103	32	)	)	-RRB-
cord-349417-vn7q8wc4	103	33	virus	virus	NN
cord-349417-vn7q8wc4	103	34	when	when	WRB
cord-349417-vn7q8wc4	103	35	transferred	transfer	VBN
cord-349417-vn7q8wc4	103	36	to	to	IN
cord-349417-vn7q8wc4	103	37	the	the	DT
cord-349417-vn7q8wc4	103	38	HCoV-229E	HCoV-229E	NNP
cord-349417-vn7q8wc4	103	39	infectious	infectious	JJ
cord-349417-vn7q8wc4	103	40	clone	clone	NN
cord-349417-vn7q8wc4	103	41	(	(	-LRB-
cord-349417-vn7q8wc4	103	42	Hertzig	Hertzig	NNP
cord-349417-vn7q8wc4	103	43	,	,	,
cord-349417-vn7q8wc4	103	44	Ulferts	Ulferts	NNP
cord-349417-vn7q8wc4	103	45	and	and	CC
cord-349417-vn7q8wc4	103	46	Ziebuhr	Ziebuhr	NNP
cord-349417-vn7q8wc4	103	47	,	,	,
cord-349417-vn7q8wc4	103	48	unpublished	unpublished	JJ
cord-349417-vn7q8wc4	103	49	data	datum	NNS
cord-349417-vn7q8wc4	103	50	)	)	-RRB-
cord-349417-vn7q8wc4	103	51	.	.	.
cord-349417-vn7q8wc4	104	1	These	these	DT
cord-349417-vn7q8wc4	104	2	data	datum	NNS
cord-349417-vn7q8wc4	104	3	indicate	indicate	VBP
cord-349417-vn7q8wc4	104	4	that	that	IN
cord-349417-vn7q8wc4	104	5	NendoU	nendou	PRP
cord-349417-vn7q8wc4	104	6	might	may	MD
cord-349417-vn7q8wc4	104	7	have	have	VB
cord-349417-vn7q8wc4	104	8	more	more	JJR
cord-349417-vn7q8wc4	104	9	than	than	IN
cord-349417-vn7q8wc4	104	10	one	one	CD
cord-349417-vn7q8wc4	104	11	activity	activity	NN
cord-349417-vn7q8wc4	104	12	and/or	and/or	CC
cord-349417-vn7q8wc4	104	13	cleave	cleave	VB
cord-349417-vn7q8wc4	104	14	more	more	JJR
cord-349417-vn7q8wc4	104	15	than	than	IN
cord-349417-vn7q8wc4	104	16	one	one	CD
cord-349417-vn7q8wc4	104	17	substrate	substrate	NN
cord-349417-vn7q8wc4	104	18	that	that	WDT
cord-349417-vn7q8wc4	104	19	likely	likely	RB
cord-349417-vn7q8wc4	104	20	differs	differ	VBZ
cord-349417-vn7q8wc4	104	21	from	from	IN
cord-349417-vn7q8wc4	104	22	that	that	DT
cord-349417-vn7q8wc4	104	23	used	use	VBN
cord-349417-vn7q8wc4	104	24	in	in	IN
cord-349417-vn7q8wc4	104	25	our	-PRON-	PRP$
cord-349417-vn7q8wc4	104	26	in	in	FW
cord-349417-vn7q8wc4	104	27	vitro	vitro	FW
cord-349417-vn7q8wc4	104	28	assays	assay	NNS
cord-349417-vn7q8wc4	104	29	.	.	.
cord-349417-vn7q8wc4	105	1	Clearly	clearly	RB
cord-349417-vn7q8wc4	105	2	,	,	,
cord-349417-vn7q8wc4	105	3	more	more	JJR
cord-349417-vn7q8wc4	105	4	work	work	NN
cord-349417-vn7q8wc4	105	5	will	will	MD
cord-349417-vn7q8wc4	105	6	be	be	VB
cord-349417-vn7q8wc4	105	7	required	require	VBN
cord-349417-vn7q8wc4	105	8	to	to	TO
cord-349417-vn7q8wc4	105	9	elucidate	elucidate	VB
cord-349417-vn7q8wc4	105	10	the	the	DT
cord-349417-vn7q8wc4	105	11	function(s	function(s	NNP
cord-349417-vn7q8wc4	105	12	)	)	-RRB-
cord-349417-vn7q8wc4	105	13	of	of	IN
cord-349417-vn7q8wc4	105	14	NendoU	NendoU	NNP
cord-349417-vn7q8wc4	105	15	in	in	IN
cord-349417-vn7q8wc4	105	16	the	the	DT
cord-349417-vn7q8wc4	105	17	nidoviral	nidoviral	JJ
cord-349417-vn7q8wc4	105	18	life	life	NNP
cord-349417-vn7q8wc4	105	19	cycle	cycle	NN
cord-349417-vn7q8wc4	105	20	.	.	.
cord-349417-vn7q8wc4	106	1	In	in	IN
cord-349417-vn7q8wc4	106	2	view	view	NN
cord-349417-vn7q8wc4	106	3	of	of	IN
cord-349417-vn7q8wc4	106	4	the	the	DT
cord-349417-vn7q8wc4	106	5	very	very	RB
cord-349417-vn7q8wc4	106	6	similar	similar	JJ
cord-349417-vn7q8wc4	106	7	gene	gene	NN
cord-349417-vn7q8wc4	106	8	expression	expression	NN
cord-349417-vn7q8wc4	106	9	and	and	CC
cord-349417-vn7q8wc4	106	10	RNA	RNA	NNP
cord-349417-vn7q8wc4	106	11	synthesis	synthesis	NN
cord-349417-vn7q8wc4	106	12	strategies	strategy	NNS
cord-349417-vn7q8wc4	106	13	employed	employ	VBN
cord-349417-vn7q8wc4	106	14	by	by	IN
cord-349417-vn7q8wc4	106	15	the	the	DT
cord-349417-vn7q8wc4	106	16	various	various	JJ
cord-349417-vn7q8wc4	106	17	nidovirus	nidovirus	NN
cord-349417-vn7q8wc4	106	18	families	family	NNS
cord-349417-vn7q8wc4	106	19	and	and	CC
cord-349417-vn7q8wc4	106	20	genera	genus	NNS
cord-349417-vn7q8wc4	106	21	,	,	,
cord-349417-vn7q8wc4	106	22	it	-PRON-	PRP
cord-349417-vn7q8wc4	106	23	is	be	VBZ
cord-349417-vn7q8wc4	106	24	intriguing	intriguing	JJ
cord-349417-vn7q8wc4	106	25	that	that	IN
cord-349417-vn7q8wc4	106	26	only	only	RB
cord-349417-vn7q8wc4	106	27	one	one	CD
cord-349417-vn7q8wc4	106	28	(	(	-LRB-
cord-349417-vn7q8wc4	106	29	namely	namely	RB
cord-349417-vn7q8wc4	106	30	NendoU	NendoU	NNP
cord-349417-vn7q8wc4	106	31	)	)	-RRB-
cord-349417-vn7q8wc4	106	32	of	of	IN
cord-349417-vn7q8wc4	106	33	the	the	DT
cord-349417-vn7q8wc4	106	34	newly	newly	RB
cord-349417-vn7q8wc4	106	35	identified	identify	VBN
cord-349417-vn7q8wc4	106	36	nidovirus	nidovirus	NNP
cord-349417-vn7q8wc4	106	37	RNA	RNA	NNP
cord-349417-vn7q8wc4	106	38	-	-	HYPH
cord-349417-vn7q8wc4	106	39	processing	process	VBG
cord-349417-vn7q8wc4	106	40	activities	activity	NNS
cord-349417-vn7q8wc4	106	41	is	be	VBZ
cord-349417-vn7q8wc4	106	42	conserved	conserve	VBN
cord-349417-vn7q8wc4	106	43	in	in	IN
cord-349417-vn7q8wc4	106	44	arteriviruses	arteriviruse	NNS
cord-349417-vn7q8wc4	106	45	.	.	.
cord-349417-vn7q8wc4	107	1	The	the	DT
cord-349417-vn7q8wc4	107	2	basis	basis	NN
cord-349417-vn7q8wc4	107	3	for	for	IN
cord-349417-vn7q8wc4	107	4	this	this	DT
cord-349417-vn7q8wc4	107	5	differential	differential	JJ
cord-349417-vn7q8wc4	107	6	conservation	conservation	NN
cord-349417-vn7q8wc4	107	7	pattern	pattern	NN
cord-349417-vn7q8wc4	107	8	of	of	IN
cord-349417-vn7q8wc4	107	9	RNA	rna	NN
cord-349417-vn7q8wc4	107	10	-	-	HYPH
cord-349417-vn7q8wc4	107	11	processing	processing	NN
cord-349417-vn7q8wc4	107	12	enzymes	enzyme	NNS
cord-349417-vn7q8wc4	107	13	is	be	VBZ
cord-349417-vn7q8wc4	107	14	currently	currently	RB
cord-349417-vn7q8wc4	107	15	unclear	unclear	JJ
cord-349417-vn7q8wc4	107	16	but	but	CC
cord-349417-vn7q8wc4	107	17	might	may	MD
cord-349417-vn7q8wc4	107	18	indicate	indicate	VB
cord-349417-vn7q8wc4	107	19	that	that	IN
cord-349417-vn7q8wc4	107	20	the	the	DT
cord-349417-vn7q8wc4	107	21	enzymology	enzymology	NN
cord-349417-vn7q8wc4	107	22	involved	involve	VBN
cord-349417-vn7q8wc4	107	23	in	in	IN
cord-349417-vn7q8wc4	107	24	viral	viral	JJ
cord-349417-vn7q8wc4	107	25	genome	genome	NN
cord-349417-vn7q8wc4	107	26	-	-	HYPH
cord-349417-vn7q8wc4	107	27	length	length	NN
cord-349417-vn7q8wc4	107	28	and	and	CC
cord-349417-vn7q8wc4	107	29	subgenome	subgenome	NN
cord-349417-vn7q8wc4	107	30	-	-	HYPH
cord-349417-vn7q8wc4	107	31	length	length	NN
cord-349417-vn7q8wc4	107	32	RNA	RNA	NNP
cord-349417-vn7q8wc4	107	33	synthesis	synthesis	NN
cord-349417-vn7q8wc4	107	34	varies	vary	VBZ
cord-349417-vn7q8wc4	107	35	to	to	IN
cord-349417-vn7q8wc4	107	36	some	some	DT
cord-349417-vn7q8wc4	107	37	extent	extent	NN
cord-349417-vn7q8wc4	107	38	among	among	IN
cord-349417-vn7q8wc4	107	39	the	the	DT
cord-349417-vn7q8wc4	107	40	nidovirus	nidovirus	NNP
cord-349417-vn7q8wc4	107	41	families	family	NNS
cord-349417-vn7q8wc4	107	42	.	.	.
cord-349417-vn7q8wc4	108	1	Alternatively	alternatively	RB
cord-349417-vn7q8wc4	108	2	,	,	,
cord-349417-vn7q8wc4	108	3	members	member	NNS
cord-349417-vn7q8wc4	108	4	of	of	IN
cord-349417-vn7q8wc4	108	5	the	the	DT
cord-349417-vn7q8wc4	108	6	various	various	JJ
cord-349417-vn7q8wc4	108	7	nidovirus	nidovirus	NNP
cord-349417-vn7q8wc4	108	8	families	family	NNS
cord-349417-vn7q8wc4	108	9	/	/	,
cord-349417-vn7q8wc4	108	10	genera	genus	NNS
cord-349417-vn7q8wc4	108	11	might	may	MD
cord-349417-vn7q8wc4	108	12	interact	interact	VB
cord-349417-vn7q8wc4	108	13	differentially	differentially	RB
cord-349417-vn7q8wc4	108	14	with	with	IN
cord-349417-vn7q8wc4	108	15	yet	yet	RB
cord-349417-vn7q8wc4	108	16	-	-	HYPH
cord-349417-vn7q8wc4	108	17	to	to	TO
cord-349417-vn7q8wc4	108	18	-	-	HYPH
cord-349417-vn7q8wc4	108	19	be	be	VB
cord-349417-vn7q8wc4	108	20	-	-	HYPH
cord-349417-vn7q8wc4	108	21	defined	define	VBN
cord-349417-vn7q8wc4	108	22	RNA	rna	NN
cord-349417-vn7q8wc4	108	23	-	-	HYPH
cord-349417-vn7q8wc4	108	24	processing	process	VBG
cord-349417-vn7q8wc4	108	25	pathways	pathway	NNS
cord-349417-vn7q8wc4	108	26	of	of	IN
cord-349417-vn7q8wc4	108	27	the	the	DT
cord-349417-vn7q8wc4	108	28	host	host	NN
cord-349417-vn7q8wc4	108	29	cell	cell	NN
cord-349417-vn7q8wc4	108	30	.	.	.
cord-349417-vn7q8wc4	109	1	It	-PRON-	PRP
cord-349417-vn7q8wc4	109	2	is	be	VBZ
cord-349417-vn7q8wc4	109	3	also	also	RB
cord-349417-vn7q8wc4	109	4	worth	worth	JJ
cord-349417-vn7q8wc4	109	5	remembering	remember	VBG
cord-349417-vn7q8wc4	109	6	that	that	IN
cord-349417-vn7q8wc4	109	7	arterivirus	arterivirus	NNP
cord-349417-vn7q8wc4	109	8	genomes	genome	NNS
cord-349417-vn7q8wc4	109	9	are	be	VBP
cord-349417-vn7q8wc4	109	10	about	about	RB
cord-349417-vn7q8wc4	109	11	2	2	CD
cord-349417-vn7q8wc4	109	12	times	time	NNS
cord-349417-vn7q8wc4	109	13	smaller	small	JJR
cord-349417-vn7q8wc4	109	14	than	than	IN
cord-349417-vn7q8wc4	109	15	other	other	JJ
cord-349417-vn7q8wc4	109	16	nidovirus	nidovirus	NN
cord-349417-vn7q8wc4	109	17	genomes	genome	NNS
cord-349417-vn7q8wc4	109	18	and	and	CC
cord-349417-vn7q8wc4	109	19	it	-PRON-	PRP
cord-349417-vn7q8wc4	109	20	is	be	VBZ
cord-349417-vn7q8wc4	109	21	possible	possible	JJ
cord-349417-vn7q8wc4	109	22	that	that	IN
cord-349417-vn7q8wc4	109	23	(	(	-LRB-
cord-349417-vn7q8wc4	109	24	some	some	DT
cord-349417-vn7q8wc4	109	25	of	of	IN
cord-349417-vn7q8wc4	109	26	)	)	-RRB-
cord-349417-vn7q8wc4	109	27	the	the	DT
cord-349417-vn7q8wc4	109	28	extra	extra	JJ
cord-349417-vn7q8wc4	109	29	domains	domain	NNS
cord-349417-vn7q8wc4	109	30	conserved	conserve	VBN
cord-349417-vn7q8wc4	109	31	in	in	IN
cord-349417-vn7q8wc4	109	32	corona	corona	NN
cord-349417-vn7q8wc4	109	33	-	-	HYPH
cord-349417-vn7q8wc4	109	34	and	and	CC
cord-349417-vn7q8wc4	109	35	toroviruses	toroviruse	NNS
cord-349417-vn7q8wc4	109	36	(	(	-LRB-
cord-349417-vn7q8wc4	109	37	and	and	CC
cord-349417-vn7q8wc4	109	38	,	,	,
cord-349417-vn7q8wc4	109	39	to	to	IN
cord-349417-vn7q8wc4	109	40	a	a	DT
cord-349417-vn7q8wc4	109	41	lesser	less	JJR
cord-349417-vn7q8wc4	109	42	extent	extent	NN
cord-349417-vn7q8wc4	109	43	,	,	,
cord-349417-vn7q8wc4	109	44	in	in	IN
cord-349417-vn7q8wc4	109	45	roniviruses	roniviruses	NNP
cord-349417-vn7q8wc4	109	46	)	)	-RRB-
cord-349417-vn7q8wc4	109	47	are	be	VBP
cord-349417-vn7q8wc4	109	48	required	require	VBN
cord-349417-vn7q8wc4	109	49	to	to	TO
cord-349417-vn7q8wc4	109	50	replicate	replicate	VB
cord-349417-vn7q8wc4	109	51	genomes	genome	NNS
cord-349417-vn7q8wc4	109	52	of	of	IN
cord-349417-vn7q8wc4	109	53	this	this	DT
cord-349417-vn7q8wc4	109	54	unique	unique	JJ
cord-349417-vn7q8wc4	109	55	size	size	NN
cord-349417-vn7q8wc4	109	56	.	.	.
cord-349417-vn7q8wc4	110	1	The	the	DT
cord-349417-vn7q8wc4	110	2	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	110	3	ExoN	ExoN	NNP
cord-349417-vn7q8wc4	110	4	activity	activity	NN
cord-349417-vn7q8wc4	110	5	was	be	VBD
cord-349417-vn7q8wc4	110	6	recently	recently	RB
cord-349417-vn7q8wc4	110	7	shown	show	VBN
cord-349417-vn7q8wc4	110	8	by	by	IN
cord-349417-vn7q8wc4	110	9	sequence	sequence	NN
cord-349417-vn7q8wc4	110	10	analysis	analysis	NN
cord-349417-vn7q8wc4	110	11	and	and	CC
cord-349417-vn7q8wc4	110	12	site	site	NN
cord-349417-vn7q8wc4	110	13	-	-	HYPH
cord-349417-vn7q8wc4	110	14	sirected	sirecte	VBN
cord-349417-vn7q8wc4	110	15	mutagenesis	mutagenesis	NN
cord-349417-vn7q8wc4	110	16	to	to	TO
cord-349417-vn7q8wc4	110	17	be	be	VB
cord-349417-vn7q8wc4	110	18	related	relate	VBN
cord-349417-vn7q8wc4	110	19	to	to	IN
cord-349417-vn7q8wc4	110	20	cellular	cellular	JJ
cord-349417-vn7q8wc4	110	21	enzymes	enzyme	NNS
cord-349417-vn7q8wc4	110	22	of	of	IN
cord-349417-vn7q8wc4	110	23	the	the	DT
cord-349417-vn7q8wc4	110	24	DEDD	DEDD	NNP
cord-349417-vn7q8wc4	110	25	exonuclease	exonuclease	NN
cord-349417-vn7q8wc4	110	26	superfamily	superfamily	NN
cord-349417-vn7q8wc4	110	27	(	(	-LRB-
cord-349417-vn7q8wc4	110	28	Minskaia	Minskaia	NNP
cord-349417-vn7q8wc4	110	29	,	,	,
cord-349417-vn7q8wc4	110	30	Hertzig	Hertzig	NNP
cord-349417-vn7q8wc4	110	31	,	,	,
cord-349417-vn7q8wc4	110	32	Gorbalenya	Gorbalenya	NNP
cord-349417-vn7q8wc4	110	33	,	,	,
cord-349417-vn7q8wc4	110	34	Campanacci	Campanacci	NNP
cord-349417-vn7q8wc4	110	35	,	,	,
cord-349417-vn7q8wc4	110	36	Cambillau	Cambillau	NNP
cord-349417-vn7q8wc4	110	37	,	,	,
cord-349417-vn7q8wc4	110	38	Canard	Canard	NNP
cord-349417-vn7q8wc4	110	39	,	,	,
cord-349417-vn7q8wc4	110	40	and	and	CC
cord-349417-vn7q8wc4	110	41	Ziebuhr	Ziebuhr	NNP
cord-349417-vn7q8wc4	110	42	,	,	,
cord-349417-vn7q8wc4	110	43	unpublished	unpublished	JJ
cord-349417-vn7q8wc4	110	44	data	datum	NNS
cord-349417-vn7q8wc4	110	45	)	)	-RRB-
cord-349417-vn7q8wc4	110	46	.	.	.
cord-349417-vn7q8wc4	111	1	This	this	DT
cord-349417-vn7q8wc4	111	2	exonuclease	exonuclease	NN
cord-349417-vn7q8wc4	111	3	family	family	NN
cord-349417-vn7q8wc4	111	4	includes	include	VBZ
cord-349417-vn7q8wc4	111	5	cellular	cellular	JJ
cord-349417-vn7q8wc4	111	6	3'-to-5	3'-to-5	CD
cord-349417-vn7q8wc4	111	7	'	'	''
cord-349417-vn7q8wc4	111	8	exonucleases	exonuclease	NNS
cord-349417-vn7q8wc4	111	9	involved	involve	VBN
cord-349417-vn7q8wc4	111	10	in	in	IN
cord-349417-vn7q8wc4	111	11	proofreading	proofreading	NN
cord-349417-vn7q8wc4	111	12	,	,	,
cord-349417-vn7q8wc4	111	13	repair	repair	NN
cord-349417-vn7q8wc4	111	14	,	,	,
cord-349417-vn7q8wc4	111	15	and/or	and/or	CC
cord-349417-vn7q8wc4	111	16	recombination	recombination	NN
cord-349417-vn7q8wc4	111	17	,	,	,
cord-349417-vn7q8wc4	111	18	and	and	CC
cord-349417-vn7q8wc4	111	19	it	-PRON-	PRP
cord-349417-vn7q8wc4	111	20	is	be	VBZ
cord-349417-vn7q8wc4	111	21	tempting	tempt	VBG
cord-349417-vn7q8wc4	111	22	to	to	TO
cord-349417-vn7q8wc4	111	23	speculate	speculate	VB
cord-349417-vn7q8wc4	111	24	that	that	IN
cord-349417-vn7q8wc4	111	25	nidoviruses	nidoviruse	NNS
cord-349417-vn7q8wc4	111	26	use	use	VBP
cord-349417-vn7q8wc4	111	27	their	-PRON-	PRP$
cord-349417-vn7q8wc4	111	28	ExoN	ExoN	NNP
cord-349417-vn7q8wc4	111	29	domains	domain	NNS
cord-349417-vn7q8wc4	111	30	in	in	IN
cord-349417-vn7q8wc4	111	31	similar	similar	JJ
cord-349417-vn7q8wc4	111	32	processes	process	NNS
cord-349417-vn7q8wc4	111	33	,	,	,
cord-349417-vn7q8wc4	111	34	for	for	IN
cord-349417-vn7q8wc4	111	35	example	example	NN
cord-349417-vn7q8wc4	111	36	,	,	,
cord-349417-vn7q8wc4	111	37	to	to	TO
cord-349417-vn7q8wc4	111	38	keep	keep	VB
cord-349417-vn7q8wc4	111	39	the	the	DT
cord-349417-vn7q8wc4	111	40	error	error	NN
cord-349417-vn7q8wc4	111	41	frequency	frequency	NN
cord-349417-vn7q8wc4	111	42	of	of	IN
cord-349417-vn7q8wc4	111	43	their	-PRON-	PRP$
cord-349417-vn7q8wc4	111	44	low	low	JJ
cord-349417-vn7q8wc4	111	45	-	-	HYPH
cord-349417-vn7q8wc4	111	46	fidelity	fidelity	NN
cord-349417-vn7q8wc4	111	47	RdRp	RdRp	NNP
cord-349417-vn7q8wc4	111	48	below	below	IN
cord-349417-vn7q8wc4	111	49	a	a	DT
cord-349417-vn7q8wc4	111	50	critical	critical	JJ
cord-349417-vn7q8wc4	111	51	thereshold	thereshold	NN
cord-349417-vn7q8wc4	111	52	.	.	.
cord-349417-vn7q8wc4	112	1	In	in	IN
cord-349417-vn7q8wc4	112	2	contrast	contrast	NN
cord-349417-vn7q8wc4	112	3	to	to	IN
cord-349417-vn7q8wc4	112	4	the	the	DT
cord-349417-vn7q8wc4	112	5	essential	essential	JJ
cord-349417-vn7q8wc4	112	6	RNA	rna	NN
cord-349417-vn7q8wc4	112	7	-	-	HYPH
cord-349417-vn7q8wc4	112	8	processing	processing	NN
cord-349417-vn7q8wc4	112	9	activities	activity	NNS
cord-349417-vn7q8wc4	112	10	(	(	-LRB-
cord-349417-vn7q8wc4	112	11	ExoN	ExoN	NNP
cord-349417-vn7q8wc4	112	12	,	,	,
cord-349417-vn7q8wc4	112	13	NendoU	NendoU	NNP
cord-349417-vn7q8wc4	112	14	,	,	,
cord-349417-vn7q8wc4	112	15	and	and	CC
cord-349417-vn7q8wc4	112	16	MT	MT	NNP
cord-349417-vn7q8wc4	112	17	)	)	-RRB-
cord-349417-vn7q8wc4	112	18	,	,	,
cord-349417-vn7q8wc4	112	19	the	the	DT
cord-349417-vn7q8wc4	112	20	nsp3	nsp3	NNS
cord-349417-vn7q8wc4	112	21	X	x	NN
cord-349417-vn7q8wc4	112	22	domain	domain	NN
cord-349417-vn7q8wc4	112	23	-	-	HYPH
cord-349417-vn7q8wc4	112	24	associated	associate	VBN
cord-349417-vn7q8wc4	112	25	Appr-1"-pase	Appr-1"-pase	NNP
cord-349417-vn7q8wc4	112	26	activity	activity	NN
cord-349417-vn7q8wc4	112	27	was	be	VBD
cord-349417-vn7q8wc4	112	28	found	find	VBN
cord-349417-vn7q8wc4	112	29	to	to	TO
cord-349417-vn7q8wc4	112	30	be	be	VB
cord-349417-vn7q8wc4	112	31	dispensable	dispensable	JJ
cord-349417-vn7q8wc4	112	32	for	for	IN
cord-349417-vn7q8wc4	112	33	viral	viral	JJ
cord-349417-vn7q8wc4	112	34	replication	replication	NN
cord-349417-vn7q8wc4	112	35	in	in	IN
cord-349417-vn7q8wc4	112	36	vitro	vitro	FW
cord-349417-vn7q8wc4	112	37	.	.	.
cord-349417-vn7q8wc4	113	1	57	57	CD
cord-349417-vn7q8wc4	113	2	Substitutions	substitution	NNS
cord-349417-vn7q8wc4	113	3	of	of	IN
cord-349417-vn7q8wc4	113	4	putative	putative	JJ
cord-349417-vn7q8wc4	113	5	active	active	JJ
cord-349417-vn7q8wc4	113	6	-	-	HYPH
cord-349417-vn7q8wc4	113	7	site	site	NN
cord-349417-vn7q8wc4	113	8	residues	residue	NNS
cord-349417-vn7q8wc4	113	9	of	of	IN
cord-349417-vn7q8wc4	113	10	the	the	DT
cord-349417-vn7q8wc4	113	11	Appr-1"-pase	Appr-1"-pase	NNP
cord-349417-vn7q8wc4	113	12	domain	domain	NN
cord-349417-vn7q8wc4	113	13	,	,	,
cord-349417-vn7q8wc4	113	14	which	which	WDT
cord-349417-vn7q8wc4	113	15	have	have	VBP
cord-349417-vn7q8wc4	113	16	been	be	VBN
cord-349417-vn7q8wc4	113	17	confirmed	confirm	VBN
cord-349417-vn7q8wc4	113	18	to	to	TO
cord-349417-vn7q8wc4	113	19	abolish	abolish	VB
cord-349417-vn7q8wc4	113	20	enzymatic	enzymatic	JJ
cord-349417-vn7q8wc4	113	21	activity	activity	NN
cord-349417-vn7q8wc4	113	22	in	in	IN
cord-349417-vn7q8wc4	113	23	vitro	vitro	FW
cord-349417-vn7q8wc4	113	24	,	,	,
cord-349417-vn7q8wc4	113	25	gave	give	VBD
cord-349417-vn7q8wc4	113	26	rise	rise	NN
cord-349417-vn7q8wc4	113	27	to	to	IN
cord-349417-vn7q8wc4	113	28	viable	viable	JJ
cord-349417-vn7q8wc4	113	29	virus	virus	NN
cord-349417-vn7q8wc4	113	30	.	.	.
cord-349417-vn7q8wc4	114	1	The	the	DT
cord-349417-vn7q8wc4	114	2	virus	virus	NN
cord-349417-vn7q8wc4	114	3	had	have	VBD
cord-349417-vn7q8wc4	114	4	no	no	DT
cord-349417-vn7q8wc4	114	5	apparent	apparent	JJ
cord-349417-vn7q8wc4	114	6	defects	defect	NNS
cord-349417-vn7q8wc4	114	7	in	in	IN
cord-349417-vn7q8wc4	114	8	viral	viral	JJ
cord-349417-vn7q8wc4	114	9	RNA	RNA	NNP
cord-349417-vn7q8wc4	114	10	synthesis	synthesis	NN
cord-349417-vn7q8wc4	114	11	and	and	CC
cord-349417-vn7q8wc4	114	12	grew	grow	VBD
cord-349417-vn7q8wc4	114	13	to	to	IN
cord-349417-vn7q8wc4	114	14	the	the	DT
cord-349417-vn7q8wc4	114	15	same	same	JJ
cord-349417-vn7q8wc4	114	16	titers	titer	NNS
cord-349417-vn7q8wc4	114	17	as	as	IN
cord-349417-vn7q8wc4	114	18	the	the	DT
cord-349417-vn7q8wc4	114	19	wild	wild	JJ
cord-349417-vn7q8wc4	114	20	-	-	HYPH
cord-349417-vn7q8wc4	114	21	type	type	NN
cord-349417-vn7q8wc4	114	22	virus	virus	NN
cord-349417-vn7q8wc4	114	23	.	.	.
cord-349417-vn7q8wc4	115	1	57	57	CD
cord-349417-vn7q8wc4	116	1	Similarly	similarly	RB
cord-349417-vn7q8wc4	116	2	,	,	,
cord-349417-vn7q8wc4	116	3	MHV	MHV	NNP
cord-349417-vn7q8wc4	116	4	reverse	reverse	VB
cord-349417-vn7q8wc4	116	5	genetics	genetics	NN
cord-349417-vn7q8wc4	116	6	data	datum	NNS
cord-349417-vn7q8wc4	117	1	demonstrated	demonstrate	VBD
cord-349417-vn7q8wc4	117	2	that	that	IN
cord-349417-vn7q8wc4	117	3	coronaviruses	coronaviruse	NNS
cord-349417-vn7q8wc4	117	4	tolerate	tolerate	VBP
cord-349417-vn7q8wc4	117	5	specific	specific	JJ
cord-349417-vn7q8wc4	117	6	substitutions	substitution	NNS
cord-349417-vn7q8wc4	117	7	and	and	CC
cord-349417-vn7q8wc4	117	8	even	even	RB
cord-349417-vn7q8wc4	117	9	deletions	deletion	NNS
cord-349417-vn7q8wc4	117	10	in	in	IN
cord-349417-vn7q8wc4	117	11	the	the	DT
cord-349417-vn7q8wc4	117	12	replicase	replicase	NN
cord-349417-vn7q8wc4	117	13	gene	gene	NN
cord-349417-vn7q8wc4	117	14	.	.	.
cord-349417-vn7q8wc4	118	1	For	for	IN
cord-349417-vn7q8wc4	118	2	example	example	NN
cord-349417-vn7q8wc4	118	3	,	,	,
cord-349417-vn7q8wc4	118	4	cleavage	cleavage	NN
cord-349417-vn7q8wc4	118	5	of	of	IN
cord-349417-vn7q8wc4	118	6	the	the	DT
cord-349417-vn7q8wc4	118	7	nsp1|nsp2	nsp1|nsp2	NNP
cord-349417-vn7q8wc4	118	8	cleavage	cleavage	NN
cord-349417-vn7q8wc4	118	9	site	site	NN
cord-349417-vn7q8wc4	118	10	was	be	VBD
cord-349417-vn7q8wc4	118	11	shown	show	VBN
cord-349417-vn7q8wc4	118	12	to	to	TO
cord-349417-vn7q8wc4	118	13	be	be	VB
cord-349417-vn7q8wc4	118	14	dispensable	dispensable	JJ
cord-349417-vn7q8wc4	118	15	for	for	IN
cord-349417-vn7q8wc4	118	16	viral	viral	JJ
cord-349417-vn7q8wc4	118	17	replication	replication	NN
cord-349417-vn7q8wc4	118	18	,	,	,
cord-349417-vn7q8wc4	118	19	and	and	CC
cord-349417-vn7q8wc4	118	20	even	even	RB
cord-349417-vn7q8wc4	118	21	deletion	deletion	NN
cord-349417-vn7q8wc4	118	22	of	of	IN
cord-349417-vn7q8wc4	118	23	the	the	DT
cord-349417-vn7q8wc4	118	24	C	C	NNP
cord-349417-vn7q8wc4	118	25	-	-	HYPH
cord-349417-vn7q8wc4	118	26	terminal	terminal	NN
cord-349417-vn7q8wc4	118	27	part	part	NN
cord-349417-vn7q8wc4	118	28	of	of	IN
cord-349417-vn7q8wc4	118	29	nsp1	nsp1	NNS
cord-349417-vn7q8wc4	118	30	and	and	CC
cord-349417-vn7q8wc4	118	31	the	the	DT
cord-349417-vn7q8wc4	118	32	entire	entire	JJ
cord-349417-vn7q8wc4	118	33	nsp2	nsp2	NN
cord-349417-vn7q8wc4	118	34	,	,	,
cord-349417-vn7q8wc4	118	35	respectively	respectively	RB
cord-349417-vn7q8wc4	118	36	,	,	,
cord-349417-vn7q8wc4	118	37	had	have	VBD
cord-349417-vn7q8wc4	118	38	only	only	JJ
cord-349417-vn7q8wc4	118	39	minor	minor	JJ
cord-349417-vn7q8wc4	118	40	effects	effect	NNS
cord-349417-vn7q8wc4	118	41	on	on	IN
cord-349417-vn7q8wc4	118	42	viral	viral	JJ
cord-349417-vn7q8wc4	118	43	replication	replication	NN
cord-349417-vn7q8wc4	118	44	.	.	.
cord-349417-vn7q8wc4	119	1	[	[	-LRB-
cord-349417-vn7q8wc4	119	2	33	33	CD
cord-349417-vn7q8wc4	119	3	]	]	-RRB-
cord-349417-vn7q8wc4	119	4	[	[	-LRB-
cord-349417-vn7q8wc4	119	5	34	34	CD
cord-349417-vn7q8wc4	119	6	]	]	-RRB-
cord-349417-vn7q8wc4	120	1	[	[	-LRB-
cord-349417-vn7q8wc4	120	2	35	35	CD
cord-349417-vn7q8wc4	120	3	]	]	-RRB-
cord-349417-vn7q8wc4	121	1	By	by	IN
cord-349417-vn7q8wc4	121	2	contrast	contrast	NN
cord-349417-vn7q8wc4	121	3	,	,	,
cord-349417-vn7q8wc4	121	4	several	several	JJ
cord-349417-vn7q8wc4	121	5	other	other	JJ
cord-349417-vn7q8wc4	121	6	mutations	mutation	NNS
cord-349417-vn7q8wc4	121	7	/	/	SYM
cord-349417-vn7q8wc4	121	8	deletions	deletion	NNS
cord-349417-vn7q8wc4	121	9	were	be	VBD
cord-349417-vn7q8wc4	121	10	tolerated	tolerate	VBN
cord-349417-vn7q8wc4	121	11	in	in	IN
cord-349417-vn7q8wc4	121	12	vitro	vitro	FW
cord-349417-vn7q8wc4	121	13	but	but	CC
cord-349417-vn7q8wc4	121	14	caused	cause	VBD
cord-349417-vn7q8wc4	121	15	attenuation	attenuation	NN
cord-349417-vn7q8wc4	121	16	in	in	IN
cord-349417-vn7q8wc4	121	17	the	the	DT
cord-349417-vn7q8wc4	121	18	natural	natural	JJ
cord-349417-vn7q8wc4	121	19	host	host	NN
cord-349417-vn7q8wc4	121	20	.	.	.
cord-349417-vn7q8wc4	122	1	58	58	CD
cord-349417-vn7q8wc4	122	2	Taken	take	VBN
cord-349417-vn7q8wc4	122	3	together	together	RB
cord-349417-vn7q8wc4	122	4	,	,	,
cord-349417-vn7q8wc4	122	5	the	the	DT
cord-349417-vn7q8wc4	122	6	data	datum	NNS
cord-349417-vn7q8wc4	122	7	suggest	suggest	VBP
cord-349417-vn7q8wc4	122	8	that	that	IN
cord-349417-vn7q8wc4	122	9	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	122	10	replicases	replicase	NNS
cord-349417-vn7q8wc4	122	11	have	have	VBP
cord-349417-vn7q8wc4	122	12	evolved	evolve	VBN
cord-349417-vn7q8wc4	122	13	to	to	TO
cord-349417-vn7q8wc4	122	14	include	include	VB
cord-349417-vn7q8wc4	122	15	a	a	DT
cord-349417-vn7q8wc4	122	16	number	number	NN
cord-349417-vn7q8wc4	122	17	of	of	IN
cord-349417-vn7q8wc4	122	18	nonessential	nonessential	JJ
cord-349417-vn7q8wc4	122	19	functions	function	NNS
cord-349417-vn7q8wc4	122	20	.	.	.
cord-349417-vn7q8wc4	123	1	The	the	DT
cord-349417-vn7q8wc4	123	2	fact	fact	NN
cord-349417-vn7q8wc4	123	3	that	that	IN
cord-349417-vn7q8wc4	123	4	some	some	DT
cord-349417-vn7q8wc4	123	5	of	of	IN
cord-349417-vn7q8wc4	123	6	the	the	DT
cord-349417-vn7q8wc4	123	7	"	"	``
cord-349417-vn7q8wc4	123	8	nonessential	nonessential	JJ
cord-349417-vn7q8wc4	123	9	"	"	''
cord-349417-vn7q8wc4	123	10	protease	protease	NN
cord-349417-vn7q8wc4	123	11	cleavages	cleavage	NNS
cord-349417-vn7q8wc4	123	12	and	and	CC
cord-349417-vn7q8wc4	123	13	enzymatic	enzymatic	JJ
cord-349417-vn7q8wc4	123	14	activities	activity	NNS
cord-349417-vn7q8wc4	123	15	are	be	VBP
cord-349417-vn7q8wc4	123	16	conserved	conserve	VBN
cord-349417-vn7q8wc4	123	17	in	in	IN
cord-349417-vn7q8wc4	123	18	coronaviruses	coronaviruse	NNS
cord-349417-vn7q8wc4	123	19	or	or	CC
cord-349417-vn7q8wc4	123	20	in	in	IN
cord-349417-vn7q8wc4	123	21	specific	specific	JJ
cord-349417-vn7q8wc4	123	22	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	123	23	genetic	genetic	JJ
cord-349417-vn7q8wc4	123	24	groups	group	NNS
cord-349417-vn7q8wc4	123	25	suggests	suggest	VBZ
cord-349417-vn7q8wc4	123	26	that	that	IN
cord-349417-vn7q8wc4	123	27	they	-PRON-	PRP
cord-349417-vn7q8wc4	123	28	provide	provide	VBP
cord-349417-vn7q8wc4	123	29	a	a	DT
cord-349417-vn7q8wc4	123	30	selective	selective	JJ
cord-349417-vn7q8wc4	123	31	advantage	advantage	NN
cord-349417-vn7q8wc4	123	32	only	only	RB
cord-349417-vn7q8wc4	123	33	in	in	IN
cord-349417-vn7q8wc4	123	34	the	the	DT
cord-349417-vn7q8wc4	123	35	host	host	NN
cord-349417-vn7q8wc4	123	36	.	.	.
cord-349417-vn7q8wc4	124	1	Although	although	IN
cord-349417-vn7q8wc4	124	2	much	much	JJ
cord-349417-vn7q8wc4	124	3	has	have	VBZ
cord-349417-vn7q8wc4	124	4	been	be	VBN
cord-349417-vn7q8wc4	124	5	learned	learn	VBN
cord-349417-vn7q8wc4	124	6	about	about	IN
cord-349417-vn7q8wc4	124	7	coronavirus	coronavirus	NNP
cord-349417-vn7q8wc4	124	8	replicase	replicase	NNP
cord-349417-vn7q8wc4	124	9	organization	organization	NN
cord-349417-vn7q8wc4	124	10	,	,	,
cord-349417-vn7q8wc4	124	11	localization	localization	NN
cord-349417-vn7q8wc4	124	12	,	,	,
cord-349417-vn7q8wc4	124	13	proteolytic	proteolytic	JJ
cord-349417-vn7q8wc4	124	14	processing	processing	NN
cord-349417-vn7q8wc4	124	15	,	,	,
cord-349417-vn7q8wc4	124	16	and	and	CC
cord-349417-vn7q8wc4	124	17	viral	viral	JJ
cord-349417-vn7q8wc4	124	18	replicative	replicative	JJ
cord-349417-vn7q8wc4	124	19	enzymes	enzyme	NNS
cord-349417-vn7q8wc4	124	20	,	,	,
cord-349417-vn7q8wc4	124	21	there	there	EX
cord-349417-vn7q8wc4	124	22	are	be	VBP
cord-349417-vn7q8wc4	124	23	still	still	RB
cord-349417-vn7q8wc4	124	24	major	major	JJ
cord-349417-vn7q8wc4	124	25	gaps	gap	NNS
cord-349417-vn7q8wc4	124	26	in	in	IN
cord-349417-vn7q8wc4	124	27	our	-PRON-	PRP$
cord-349417-vn7q8wc4	124	28	knowledge	knowledge	NN
cord-349417-vn7q8wc4	124	29	.	.	.
cord-349417-vn7q8wc4	125	1	Inspired	inspire	VBN
cord-349417-vn7q8wc4	125	2	by	by	IN
cord-349417-vn7q8wc4	125	3	the	the	DT
cord-349417-vn7q8wc4	125	4	SARS	SARS	NNP
cord-349417-vn7q8wc4	125	5	epidemic	epidemic	NN
cord-349417-vn7q8wc4	125	6	in	in	IN
cord-349417-vn7q8wc4	125	7	2003	2003	CD
cord-349417-vn7q8wc4	125	8	,	,	,
cord-349417-vn7q8wc4	125	9	numerous	numerous	JJ
cord-349417-vn7q8wc4	125	10	studies	study	NNS
cord-349417-vn7q8wc4	125	11	aiming	aim	VBG
cord-349417-vn7q8wc4	125	12	at	at	IN
cord-349417-vn7q8wc4	125	13	the	the	DT
cord-349417-vn7q8wc4	125	14	development	development	NN
cord-349417-vn7q8wc4	125	15	of	of	IN
cord-349417-vn7q8wc4	125	16	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	125	17	vaccines	vaccine	NNS
cord-349417-vn7q8wc4	125	18	and	and	CC
cord-349417-vn7q8wc4	125	19	antivirals	antiviral	NNS
cord-349417-vn7q8wc4	125	20	have	have	VBP
cord-349417-vn7q8wc4	125	21	recently	recently	RB
cord-349417-vn7q8wc4	125	22	been	be	VBN
cord-349417-vn7q8wc4	125	23	published	publish	VBN
cord-349417-vn7q8wc4	125	24	,	,	,
cord-349417-vn7q8wc4	125	25	and	and	CC
cord-349417-vn7q8wc4	125	26	there	there	EX
cord-349417-vn7q8wc4	125	27	is	be	VBZ
cord-349417-vn7q8wc4	125	28	no	no	DT
cord-349417-vn7q8wc4	125	29	doubt	doubt	NN
cord-349417-vn7q8wc4	125	30	that	that	IN
cord-349417-vn7q8wc4	125	31	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	125	32	research	research	NN
cord-349417-vn7q8wc4	125	33	has	have	VBZ
cord-349417-vn7q8wc4	125	34	gained	gain	VBN
cord-349417-vn7q8wc4	125	35	momentum	momentum	NN
cord-349417-vn7q8wc4	125	36	over	over	IN
cord-349417-vn7q8wc4	125	37	the	the	DT
cord-349417-vn7q8wc4	125	38	past	past	JJ
cord-349417-vn7q8wc4	125	39	few	few	JJ
cord-349417-vn7q8wc4	125	40	years	year	NNS
cord-349417-vn7q8wc4	125	41	.	.	.
cord-349417-vn7q8wc4	126	1	Given	give	VBN
cord-349417-vn7q8wc4	126	2	the	the	DT
cord-349417-vn7q8wc4	126	3	rapidly	rapidly	RB
cord-349417-vn7q8wc4	126	4	accumulating	accumulate	VBG
cord-349417-vn7q8wc4	126	5	biochemical	biochemical	JJ
cord-349417-vn7q8wc4	126	6	,	,	,
cord-349417-vn7q8wc4	126	7	structural	structural	JJ
cord-349417-vn7q8wc4	126	8	,	,	,
cord-349417-vn7q8wc4	126	9	and	and	CC
cord-349417-vn7q8wc4	126	10	genetic	genetic	JJ
cord-349417-vn7q8wc4	126	11	information	information	NN
cord-349417-vn7q8wc4	126	12	on	on	IN
cord-349417-vn7q8wc4	126	13	coronaviruses	coronaviruse	NNS
cord-349417-vn7q8wc4	126	14	,	,	,
cord-349417-vn7q8wc4	126	15	a	a	DT
cord-349417-vn7q8wc4	126	16	more	more	RBR
cord-349417-vn7q8wc4	126	17	detailed	detailed	JJ
cord-349417-vn7q8wc4	126	18	understanding	understanding	NN
cord-349417-vn7q8wc4	126	19	of	of	IN
cord-349417-vn7q8wc4	126	20	the	the	DT
cord-349417-vn7q8wc4	126	21	molecular	molecular	JJ
cord-349417-vn7q8wc4	126	22	mechanisms	mechanism	NNS
cord-349417-vn7q8wc4	126	23	involved	involve	VBN
cord-349417-vn7q8wc4	126	24	in	in	IN
cord-349417-vn7q8wc4	126	25	coronaviral	coronaviral	JJ
cord-349417-vn7q8wc4	126	26	RNA	RNA	NNP
cord-349417-vn7q8wc4	126	27	synthesis	synthesis	NN
cord-349417-vn7q8wc4	126	28	can	can	MD
cord-349417-vn7q8wc4	126	29	be	be	VB
cord-349417-vn7q8wc4	126	30	expected	expect	VBN
cord-349417-vn7q8wc4	126	31	to	to	TO
cord-349417-vn7q8wc4	126	32	emerge	emerge	VB
cord-349417-vn7q8wc4	126	33	in	in	IN
cord-349417-vn7q8wc4	126	34	the	the	DT
cord-349417-vn7q8wc4	126	35	near	near	JJ
cord-349417-vn7q8wc4	126	36	future	future	NN
cord-349417-vn7q8wc4	126	37	.	.	.
cord-349417-vn7q8wc4	127	1	It	-PRON-	PRP
cord-349417-vn7q8wc4	127	2	will	will	MD
cord-349417-vn7q8wc4	127	3	be	be	VB
cord-349417-vn7q8wc4	127	4	of	of	IN
cord-349417-vn7q8wc4	127	5	particular	particular	JJ
cord-349417-vn7q8wc4	127	6	interest	interest	NN
cord-349417-vn7q8wc4	127	7	to	to	TO
cord-349417-vn7q8wc4	127	8	identify	identify	VB
cord-349417-vn7q8wc4	127	9	those	those	DT
cord-349417-vn7q8wc4	127	10	proteins	protein	NNS
cord-349417-vn7q8wc4	127	11	that	that	WDT
cord-349417-vn7q8wc4	127	12	are	be	VBP
cord-349417-vn7q8wc4	127	13	involved	involve	VBN
cord-349417-vn7q8wc4	127	14	in	in	IN
cord-349417-vn7q8wc4	127	15	the	the	DT
cord-349417-vn7q8wc4	127	16	specific	specific	JJ
cord-349417-vn7q8wc4	127	17	mechanisms	mechanism	NNS
cord-349417-vn7q8wc4	127	18	of	of	IN
cord-349417-vn7q8wc4	127	19	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	127	20	RNA	RNA	NNP
cord-349417-vn7q8wc4	127	21	synthesis	synthesis	NN
cord-349417-vn7q8wc4	127	22	,	,	,
cord-349417-vn7q8wc4	127	23	such	such	JJ
cord-349417-vn7q8wc4	127	24	as	as	IN
cord-349417-vn7q8wc4	127	25	the	the	DT
cord-349417-vn7q8wc4	127	26	production	production	NN
cord-349417-vn7q8wc4	127	27	of	of	IN
cord-349417-vn7q8wc4	127	28	a	a	DT
cord-349417-vn7q8wc4	127	29	nested	nested	JJ
cord-349417-vn7q8wc4	127	30	set	set	NN
cord-349417-vn7q8wc4	127	31	of	of	IN
cord-349417-vn7q8wc4	127	32	subgenome	subgenome	NN
cord-349417-vn7q8wc4	127	33	-	-	HYPH
cord-349417-vn7q8wc4	127	34	length	length	NN
cord-349417-vn7q8wc4	127	35	RNAs	rna	NNS
cord-349417-vn7q8wc4	127	36	and	and	CC
cord-349417-vn7q8wc4	127	37	the	the	DT
cord-349417-vn7q8wc4	127	38	replication	replication	NN
cord-349417-vn7q8wc4	127	39	of	of	IN
cord-349417-vn7q8wc4	127	40	RNA	RNA	NNP
cord-349417-vn7q8wc4	127	41	genomes	genome	NNS
cord-349417-vn7q8wc4	127	42	of	of	IN
cord-349417-vn7q8wc4	127	43	unprecedented	unprecedented	JJ
cord-349417-vn7q8wc4	127	44	size	size	NN
cord-349417-vn7q8wc4	127	45	.	.	.
cord-349417-vn7q8wc4	128	1	Furthermore	furthermore	RB
cord-349417-vn7q8wc4	128	2	,	,	,
cord-349417-vn7q8wc4	128	3	studies	study	NNS
cord-349417-vn7q8wc4	128	4	on	on	IN
cord-349417-vn7q8wc4	128	5	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	128	6	-	-	HYPH
cord-349417-vn7q8wc4	128	7	encoded	encode	VBN
cord-349417-vn7q8wc4	128	8	RNA	rna	NN
cord-349417-vn7q8wc4	128	9	-	-	HYPH
cord-349417-vn7q8wc4	128	10	processing	process	VBG
cord-349417-vn7q8wc4	128	11	activities	activity	NNS
cord-349417-vn7q8wc4	128	12	and	and	CC
cord-349417-vn7q8wc4	128	13	their	-PRON-	PRP$
cord-349417-vn7q8wc4	128	14	cellular	cellular	JJ
cord-349417-vn7q8wc4	128	15	homologs	homolog	NNS
cord-349417-vn7q8wc4	128	16	might	may	MD
cord-349417-vn7q8wc4	128	17	reveal	reveal	VB
cord-349417-vn7q8wc4	128	18	interesting	interesting	JJ
cord-349417-vn7q8wc4	128	19	insights	insight	NNS
cord-349417-vn7q8wc4	128	20	into	into	IN
cord-349417-vn7q8wc4	128	21	the	the	DT
cord-349417-vn7q8wc4	128	22	relationship	relationship	NN
cord-349417-vn7q8wc4	128	23	(	(	-LRB-
cord-349417-vn7q8wc4	128	24	or	or	CC
cord-349417-vn7q8wc4	128	25	interplay	interplay	JJ
cord-349417-vn7q8wc4	128	26	)	)	-RRB-
cord-349417-vn7q8wc4	128	27	of	of	IN
cord-349417-vn7q8wc4	128	28	coronaviral	coronaviral	JJ
cord-349417-vn7q8wc4	128	29	and	and	CC
cord-349417-vn7q8wc4	128	30	cellular	cellular	JJ
cord-349417-vn7q8wc4	128	31	RNA	RNA	NNP
cord-349417-vn7q8wc4	128	32	metabolism	metabolism	NN
cord-349417-vn7q8wc4	128	33	pathways	pathway	NNS
cord-349417-vn7q8wc4	128	34	.	.	.
cord-349417-vn7q8wc4	129	1	In	in	IN
cord-349417-vn7q8wc4	129	2	the	the	DT
cord-349417-vn7q8wc4	129	3	long	long	JJ
cord-349417-vn7q8wc4	129	4	run	run	NN
cord-349417-vn7q8wc4	129	5	,	,	,
cord-349417-vn7q8wc4	129	6	the	the	DT
cord-349417-vn7q8wc4	129	7	unique	unique	JJ
cord-349417-vn7q8wc4	129	8	structural	structural	JJ
cord-349417-vn7q8wc4	129	9	properties	property	NNS
cord-349417-vn7q8wc4	129	10	of	of	IN
cord-349417-vn7q8wc4	129	11	several	several	JJ
cord-349417-vn7q8wc4	129	12	conserved	conserve	VBN
cord-349417-vn7q8wc4	129	13	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	129	14	replicative	replicative	JJ
cord-349417-vn7q8wc4	129	15	enzymes	enzyme	NNS
cord-349417-vn7q8wc4	129	16	may	may	MD
cord-349417-vn7q8wc4	129	17	lead	lead	VB
cord-349417-vn7q8wc4	129	18	to	to	IN
cord-349417-vn7q8wc4	129	19	the	the	DT
cord-349417-vn7q8wc4	129	20	development	development	NN
cord-349417-vn7q8wc4	129	21	of	of	IN
cord-349417-vn7q8wc4	129	22	selective	selective	JJ
cord-349417-vn7q8wc4	129	23	enzyme	enzyme	NN
cord-349417-vn7q8wc4	129	24	inhibitors	inhibitor	NNS
cord-349417-vn7q8wc4	129	25	and	and	CC
cord-349417-vn7q8wc4	129	26	possibly	possibly	RB
cord-349417-vn7q8wc4	129	27	even	even	RB
cord-349417-vn7q8wc4	129	28	drugs	drug	NNS
cord-349417-vn7q8wc4	129	29	suitable	suitable	JJ
cord-349417-vn7q8wc4	129	30	to	to	TO
cord-349417-vn7q8wc4	129	31	treat	treat	VB
cord-349417-vn7q8wc4	129	32	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	129	33	infections	infection	NNS
cord-349417-vn7q8wc4	129	34	of	of	IN
cord-349417-vn7q8wc4	129	35	humans	human	NNS
cord-349417-vn7q8wc4	129	36	and	and	CC
cord-349417-vn7q8wc4	129	37	animals	animal	NNS
cord-349417-vn7q8wc4	129	38	.	.	.
cord-349417-vn7q8wc4	130	1	My	-PRON-	PRP$
cord-349417-vn7q8wc4	130	2	work	work	NN
cord-349417-vn7q8wc4	130	3	is	be	VBZ
cord-349417-vn7q8wc4	130	4	supported	support	VBN
cord-349417-vn7q8wc4	130	5	by	by	IN
cord-349417-vn7q8wc4	130	6	the	the	DT
cord-349417-vn7q8wc4	130	7	Deutsche	Deutsche	NNP
cord-349417-vn7q8wc4	130	8	Forschungsgemeinschaft	Forschungsgemeinschaft	NNP
cord-349417-vn7q8wc4	130	9	and	and	CC
cord-349417-vn7q8wc4	130	10	the	the	DT
cord-349417-vn7q8wc4	130	11	European	European	NNP
cord-349417-vn7q8wc4	130	12	Commission	Commission	NNP
cord-349417-vn7q8wc4	130	13	.	.	.
cord-349417-vn7q8wc4	131	1	Nidovirales	nidovirale	NNS
cord-349417-vn7q8wc4	131	2	:	:	:
cord-349417-vn7q8wc4	131	3	a	a	DT
cord-349417-vn7q8wc4	131	4	new	new	JJ
cord-349417-vn7q8wc4	131	5	order	order	NN
cord-349417-vn7q8wc4	131	6	comprising	comprise	VBG
cord-349417-vn7q8wc4	131	7	Coronaviridae	Coronaviridae	NNP
cord-349417-vn7q8wc4	131	8	and	and	CC
cord-349417-vn7q8wc4	131	9	Arteriviridae	Arteriviridae	NNP
cord-349417-vn7q8wc4	131	10	A	a	DT
cord-349417-vn7q8wc4	131	11	comparative	comparative	JJ
cord-349417-vn7q8wc4	131	12	sequence	sequence	NN
cord-349417-vn7q8wc4	131	13	analysis	analysis	NN
cord-349417-vn7q8wc4	131	14	to	to	TO
cord-349417-vn7q8wc4	131	15	revise	revise	VB
cord-349417-vn7q8wc4	131	16	the	the	DT
cord-349417-vn7q8wc4	131	17	current	current	JJ
cord-349417-vn7q8wc4	131	18	taxonomy	taxonomy	NN
cord-349417-vn7q8wc4	131	19	of	of	IN
cord-349417-vn7q8wc4	131	20	the	the	DT
cord-349417-vn7q8wc4	131	21	family	family	NN
cord-349417-vn7q8wc4	132	1	Coronaviridae	Coronaviridae	NNP
cord-349417-vn7q8wc4	132	2	Topley	Topley	NNP
cord-349417-vn7q8wc4	132	3	and	and	CC
cord-349417-vn7q8wc4	132	4	Wilson	Wilson	NNP
cord-349417-vn7q8wc4	132	5	's	's	POS
cord-349417-vn7q8wc4	132	6	Microbiology	Microbiology	NNP
cord-349417-vn7q8wc4	132	7	and	and	CC
cord-349417-vn7q8wc4	132	8	Microbial	Microbial	NNP
cord-349417-vn7q8wc4	132	9	Infections	Infections	NNPS
cord-349417-vn7q8wc4	132	10	Coronavirus	Coronavirus	NNP
cord-349417-vn7q8wc4	132	11	mRNA	mrna	NN
cord-349417-vn7q8wc4	133	1	synthesis	synthesis	NN
cord-349417-vn7q8wc4	133	2	involves	involve	VBZ
cord-349417-vn7q8wc4	133	3	fusion	fusion	NN
cord-349417-vn7q8wc4	133	4	of	of	IN
cord-349417-vn7q8wc4	133	5	non	non	JJ
cord-349417-vn7q8wc4	133	6	-	-	JJ
cord-349417-vn7q8wc4	133	7	contiguous	contiguous	JJ
cord-349417-vn7q8wc4	133	8	sequences	sequence	NNS
cord-349417-vn7q8wc4	134	1	An	an	DT
cord-349417-vn7q8wc4	134	2	efficient	efficient	JJ
cord-349417-vn7q8wc4	134	3	ribosomal	ribosomal	JJ
cord-349417-vn7q8wc4	134	4	frame	frame	NN
cord-349417-vn7q8wc4	134	5	-	-	HYPH
cord-349417-vn7q8wc4	134	6	shifting	shift	VBG
cord-349417-vn7q8wc4	134	7	signal	signal	NN
cord-349417-vn7q8wc4	134	8	in	in	IN
cord-349417-vn7q8wc4	134	9	the	the	DT
cord-349417-vn7q8wc4	134	10	polymerase	polymerase	NN
cord-349417-vn7q8wc4	134	11	-	-	HYPH
cord-349417-vn7q8wc4	134	12	encoding	encode	VBG
cord-349417-vn7q8wc4	134	13	region	region	NN
cord-349417-vn7q8wc4	134	14	of	of	IN
cord-349417-vn7q8wc4	134	15	the	the	DT
cord-349417-vn7q8wc4	134	16	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	134	17	IBV	IBV	NNP
cord-349417-vn7q8wc4	134	18	Coronavirus	Coronavirus	NNP
cord-349417-vn7q8wc4	134	19	genome	genome	NN
cord-349417-vn7q8wc4	134	20	:	:	:
cord-349417-vn7q8wc4	134	21	prediction	prediction	NN
cord-349417-vn7q8wc4	134	22	of	of	IN
cord-349417-vn7q8wc4	134	23	putative	putative	JJ
cord-349417-vn7q8wc4	134	24	functional	functional	JJ
cord-349417-vn7q8wc4	134	25	domains	domain	NNS
cord-349417-vn7q8wc4	134	26	in	in	IN
cord-349417-vn7q8wc4	134	27	the	the	DT
cord-349417-vn7q8wc4	134	28	non	non	JJ
cord-349417-vn7q8wc4	134	29	-	-	JJ
cord-349417-vn7q8wc4	134	30	structural	structural	JJ
cord-349417-vn7q8wc4	134	31	polyprotein	polyprotein	NN
cord-349417-vn7q8wc4	134	32	by	by	IN
cord-349417-vn7q8wc4	134	33	comparative	comparative	JJ
cord-349417-vn7q8wc4	134	34	amino	amino	NN
cord-349417-vn7q8wc4	134	35	acid	acid	NN
cord-349417-vn7q8wc4	134	36	sequence	sequence	NN
cord-349417-vn7q8wc4	134	37	analysis	analysis	NN
cord-349417-vn7q8wc4	134	38	Big	big	JJ
cord-349417-vn7q8wc4	134	39	nidovirus	nidovirus	NN
cord-349417-vn7q8wc4	134	40	genome	genome	NN
cord-349417-vn7q8wc4	134	41	.	.	.
cord-349417-vn7q8wc4	135	1	When	when	WRB
cord-349417-vn7q8wc4	135	2	count	count	NN
cord-349417-vn7q8wc4	135	3	and	and	CC
cord-349417-vn7q8wc4	135	4	order	order	NN
cord-349417-vn7q8wc4	135	5	of	of	IN
cord-349417-vn7q8wc4	135	6	domains	domain	NNS
cord-349417-vn7q8wc4	135	7	matter	matter	VBP
cord-349417-vn7q8wc4	135	8	Unique	unique	JJ
cord-349417-vn7q8wc4	135	9	and	and	CC
cord-349417-vn7q8wc4	135	10	conserved	conserve	VBN
cord-349417-vn7q8wc4	135	11	features	feature	NNS
cord-349417-vn7q8wc4	135	12	of	of	IN
cord-349417-vn7q8wc4	135	13	genome	genome	NN
cord-349417-vn7q8wc4	135	14	and	and	CC
cord-349417-vn7q8wc4	135	15	proteome	proteome	NN
cord-349417-vn7q8wc4	135	16	of	of	IN
cord-349417-vn7q8wc4	135	17	SARS	SARS	NNP
cord-349417-vn7q8wc4	135	18	-	-	HYPH
cord-349417-vn7q8wc4	135	19	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	135	20	,	,	,
cord-349417-vn7q8wc4	135	21	an	an	DT
cord-349417-vn7q8wc4	135	22	early	early	JJ
cord-349417-vn7q8wc4	135	23	split	split	NN
cord-349417-vn7q8wc4	135	24	-	-	HYPH
cord-349417-vn7q8wc4	135	25	off	off	NN
cord-349417-vn7q8wc4	135	26	from	from	IN
cord-349417-vn7q8wc4	135	27	the	the	DT
cord-349417-vn7q8wc4	135	28	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	135	29	group	group	NN
cord-349417-vn7q8wc4	135	30	2	2	CD
cord-349417-vn7q8wc4	135	31	lineage	lineage	NN
cord-349417-vn7q8wc4	136	1	The	the	DT
cord-349417-vn7q8wc4	136	2	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	136	3	replicase	replicase	NN
cord-349417-vn7q8wc4	136	4	An	An	NNP
cord-349417-vn7q8wc4	136	5	'	'	``
cord-349417-vn7q8wc4	136	6	elaborated	elaborate	VBN
cord-349417-vn7q8wc4	136	7	'	'	''
cord-349417-vn7q8wc4	136	8	pseudoknot	pseudoknot	NNP
cord-349417-vn7q8wc4	136	9	is	be	VBZ
cord-349417-vn7q8wc4	136	10	required	require	VBN
cord-349417-vn7q8wc4	136	11	for	for	IN
cord-349417-vn7q8wc4	136	12	high	high	JJ
cord-349417-vn7q8wc4	136	13	frequency	frequency	NN
cord-349417-vn7q8wc4	136	14	frameshifting	frameshifte	VBG
cord-349417-vn7q8wc4	136	15	during	during	IN
cord-349417-vn7q8wc4	136	16	translation	translation	NN
cord-349417-vn7q8wc4	136	17	of	of	IN
cord-349417-vn7q8wc4	136	18	HCV	HCV	NNP
cord-349417-vn7q8wc4	136	19	229E	229E	NNP
cord-349417-vn7q8wc4	136	20	polymerase	polymerase	NN
cord-349417-vn7q8wc4	136	21	mRNA	mrna	NN
cord-349417-vn7q8wc4	137	1	The	the	DT
cord-349417-vn7q8wc4	137	2	nucleoprotein	nucleoprotein	NN
cord-349417-vn7q8wc4	137	3	is	be	VBZ
cord-349417-vn7q8wc4	137	4	required	require	VBN
cord-349417-vn7q8wc4	137	5	for	for	IN
cord-349417-vn7q8wc4	137	6	efficient	efficient	JJ
cord-349417-vn7q8wc4	137	7	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	137	8	genome	genome	NN
cord-349417-vn7q8wc4	137	9	replication	replication	NN
cord-349417-vn7q8wc4	137	10	Selective	selective	JJ
cord-349417-vn7q8wc4	137	11	replication	replication	NN
cord-349417-vn7q8wc4	137	12	of	of	IN
cord-349417-vn7q8wc4	137	13	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	137	14	genomes	genome	NNS
cord-349417-vn7q8wc4	137	15	that	that	WDT
cord-349417-vn7q8wc4	137	16	express	express	VBP
cord-349417-vn7q8wc4	137	17	nucleocapsid	nucleocapsid	NN
cord-349417-vn7q8wc4	137	18	protein	protein	NN
cord-349417-vn7q8wc4	137	19	Viral	viral	JJ
cord-349417-vn7q8wc4	137	20	and	and	CC
cord-349417-vn7q8wc4	137	21	cellular	cellular	JJ
cord-349417-vn7q8wc4	137	22	proteins	protein	NNS
cord-349417-vn7q8wc4	137	23	involved	involve	VBN
cord-349417-vn7q8wc4	137	24	in	in	IN
cord-349417-vn7q8wc4	137	25	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	137	26	replication	replication	NN
cord-349417-vn7q8wc4	137	27	Molecular	molecular	JJ
cord-349417-vn7q8wc4	137	28	biology	biology	NN
cord-349417-vn7q8wc4	137	29	of	of	IN
cord-349417-vn7q8wc4	137	30	severe	severe	JJ
cord-349417-vn7q8wc4	137	31	acute	acute	JJ
cord-349417-vn7q8wc4	137	32	respiratory	respiratory	JJ
cord-349417-vn7q8wc4	137	33	syndrome	syndrome	NN
cord-349417-vn7q8wc4	137	34	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	137	35	Virus	virus	NN
cord-349417-vn7q8wc4	137	36	-	-	HYPH
cord-349417-vn7q8wc4	137	37	encoded	encode	VBN
cord-349417-vn7q8wc4	137	38	proteinases	proteinase	NNS
cord-349417-vn7q8wc4	137	39	and	and	CC
cord-349417-vn7q8wc4	137	40	proteolytic	proteolytic	JJ
cord-349417-vn7q8wc4	137	41	processing	processing	NN
cord-349417-vn7q8wc4	137	42	in	in	IN
cord-349417-vn7q8wc4	137	43	the	the	DT
cord-349417-vn7q8wc4	137	44	Nidovirales	Nidovirales	NNP
cord-349417-vn7q8wc4	137	45	Structure	Structure	NNP
cord-349417-vn7q8wc4	137	46	of	of	IN
cord-349417-vn7q8wc4	137	47	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	138	1	main	main	JJ
cord-349417-vn7q8wc4	138	2	proteinase	proteinase	NN
cord-349417-vn7q8wc4	138	3	reveals	reveal	VBZ
cord-349417-vn7q8wc4	138	4	combination	combination	NN
cord-349417-vn7q8wc4	138	5	of	of	IN
cord-349417-vn7q8wc4	138	6	a	a	DT
cord-349417-vn7q8wc4	138	7	chymotrypsin	chymotrypsin	NN
cord-349417-vn7q8wc4	138	8	fold	fold	JJ
cord-349417-vn7q8wc4	138	9	with	with	IN
cord-349417-vn7q8wc4	138	10	an	an	DT
cord-349417-vn7q8wc4	138	11	extra	extra	JJ
cord-349417-vn7q8wc4	138	12	alpha	alpha	JJ
cord-349417-vn7q8wc4	138	13	-	-	HYPH
cord-349417-vn7q8wc4	138	14	helical	helical	JJ
cord-349417-vn7q8wc4	138	15	domain	domain	NN
cord-349417-vn7q8wc4	138	16	Coronavirus	Coronavirus	NNP
cord-349417-vn7q8wc4	138	17	main	main	JJ
cord-349417-vn7q8wc4	138	18	proteinase	proteinase	NN
cord-349417-vn7q8wc4	138	19	(	(	-LRB-
cord-349417-vn7q8wc4	138	20	3CL	3CL	NNP
cord-349417-vn7q8wc4	138	21	pro	pro	JJ
cord-349417-vn7q8wc4	138	22	)	)	-RRB-
cord-349417-vn7q8wc4	138	23	structure	structure	NN
cord-349417-vn7q8wc4	138	24	:	:	:
cord-349417-vn7q8wc4	138	25	basis	basis	NN
cord-349417-vn7q8wc4	138	26	for	for	IN
cord-349417-vn7q8wc4	138	27	design	design	NN
cord-349417-vn7q8wc4	138	28	of	of	IN
cord-349417-vn7q8wc4	138	29	anti	anti	JJ
cord-349417-vn7q8wc4	138	30	-	-	JJ
cord-349417-vn7q8wc4	138	31	SARS	SARS	NNP
cord-349417-vn7q8wc4	138	32	drugs	drug	NNS
cord-349417-vn7q8wc4	138	33	Dissection	Dissection	NNP
cord-349417-vn7q8wc4	138	34	study	study	NN
cord-349417-vn7q8wc4	138	35	on	on	IN
cord-349417-vn7q8wc4	138	36	the	the	DT
cord-349417-vn7q8wc4	138	37	severe	severe	JJ
cord-349417-vn7q8wc4	138	38	acute	acute	JJ
cord-349417-vn7q8wc4	138	39	respiratory	respiratory	JJ
cord-349417-vn7q8wc4	138	40	syndrome	syndrome	NN
cord-349417-vn7q8wc4	138	41	3C	3c	NN
cord-349417-vn7q8wc4	138	42	-	-	HYPH
cord-349417-vn7q8wc4	138	43	like	like	JJ
cord-349417-vn7q8wc4	139	1	protease	protease	NN
cord-349417-vn7q8wc4	139	2	reveals	reveal	VBZ
cord-349417-vn7q8wc4	139	3	the	the	DT
cord-349417-vn7q8wc4	139	4	critical	critical	JJ
cord-349417-vn7q8wc4	139	5	role	role	NN
cord-349417-vn7q8wc4	139	6	of	of	IN
cord-349417-vn7q8wc4	139	7	the	the	DT
cord-349417-vn7q8wc4	139	8	extra	extra	JJ
cord-349417-vn7q8wc4	139	9	domain	domain	NN
cord-349417-vn7q8wc4	139	10	in	in	IN
cord-349417-vn7q8wc4	139	11	dimerization	dimerization	NN
cord-349417-vn7q8wc4	139	12	of	of	IN
cord-349417-vn7q8wc4	139	13	the	the	DT
cord-349417-vn7q8wc4	139	14	enzyme	enzyme	NN
cord-349417-vn7q8wc4	139	15	:	:	:
cord-349417-vn7q8wc4	139	16	defining	define	VBG
cord-349417-vn7q8wc4	139	17	the	the	DT
cord-349417-vn7q8wc4	139	18	extra	extra	JJ
cord-349417-vn7q8wc4	139	19	domain	domain	NN
cord-349417-vn7q8wc4	139	20	as	as	IN
cord-349417-vn7q8wc4	139	21	a	a	DT
cord-349417-vn7q8wc4	139	22	new	new	JJ
cord-349417-vn7q8wc4	139	23	target	target	NN
cord-349417-vn7q8wc4	139	24	for	for	IN
cord-349417-vn7q8wc4	139	25	design	design	NN
cord-349417-vn7q8wc4	139	26	of	of	IN
cord-349417-vn7q8wc4	139	27	highly	highly	RB
cord-349417-vn7q8wc4	139	28	specific	specific	JJ
cord-349417-vn7q8wc4	139	29	protease	protease	NN
cord-349417-vn7q8wc4	139	30	inhibitors	inhibitor	NNS
cord-349417-vn7q8wc4	139	31	Critical	critical	JJ
cord-349417-vn7q8wc4	139	32	assessment	assessment	NN
cord-349417-vn7q8wc4	139	33	of	of	IN
cord-349417-vn7q8wc4	139	34	important	important	JJ
cord-349417-vn7q8wc4	139	35	regions	region	NNS
cord-349417-vn7q8wc4	139	36	in	in	IN
cord-349417-vn7q8wc4	139	37	the	the	DT
cord-349417-vn7q8wc4	139	38	subunit	subunit	NN
cord-349417-vn7q8wc4	139	39	association	association	NN
cord-349417-vn7q8wc4	139	40	and	and	CC
cord-349417-vn7q8wc4	139	41	catalytic	catalytic	JJ
cord-349417-vn7q8wc4	139	42	action	action	NN
cord-349417-vn7q8wc4	139	43	of	of	IN
cord-349417-vn7q8wc4	139	44	the	the	DT
cord-349417-vn7q8wc4	139	45	severe	severe	JJ
cord-349417-vn7q8wc4	139	46	acute	acute	JJ
cord-349417-vn7q8wc4	139	47	respiratory	respiratory	JJ
cord-349417-vn7q8wc4	139	48	syndrome	syndrome	NN
cord-349417-vn7q8wc4	139	49	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	139	50	main	main	JJ
cord-349417-vn7q8wc4	139	51	protease	protease	NN
cord-349417-vn7q8wc4	139	52	Severe	severe	JJ
cord-349417-vn7q8wc4	139	53	acute	acute	JJ
cord-349417-vn7q8wc4	139	54	respiratory	respiratory	JJ
cord-349417-vn7q8wc4	139	55	syndrome	syndrome	NN
cord-349417-vn7q8wc4	139	56	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	139	57	3C	3c	NN
cord-349417-vn7q8wc4	139	58	-	-	HYPH
cord-349417-vn7q8wc4	139	59	like	like	JJ
cord-349417-vn7q8wc4	139	60	proteinase	proteinase	NN
cord-349417-vn7q8wc4	139	61	N	n	CD
cord-349417-vn7q8wc4	139	62	terminus	terminus	NN
cord-349417-vn7q8wc4	139	63	is	be	VBZ
cord-349417-vn7q8wc4	139	64	indispensable	indispensable	JJ
cord-349417-vn7q8wc4	139	65	for	for	IN
cord-349417-vn7q8wc4	139	66	proteolytic	proteolytic	JJ
cord-349417-vn7q8wc4	139	67	activity	activity	NN
cord-349417-vn7q8wc4	139	68	but	but	CC
cord-349417-vn7q8wc4	139	69	not	not	RB
cord-349417-vn7q8wc4	139	70	for	for	IN
cord-349417-vn7q8wc4	139	71	enzyme	enzyme	NN
cord-349417-vn7q8wc4	139	72	dimerization	dimerization	NN
cord-349417-vn7q8wc4	139	73	.	.	.
cord-349417-vn7q8wc4	140	1	Biochemical	biochemical	JJ
cord-349417-vn7q8wc4	140	2	and	and	CC
cord-349417-vn7q8wc4	140	3	thermodynamic	thermodynamic	JJ
cord-349417-vn7q8wc4	140	4	investigation	investigation	NN
cord-349417-vn7q8wc4	140	5	in	in	IN
cord-349417-vn7q8wc4	140	6	conjunction	conjunction	NN
cord-349417-vn7q8wc4	140	7	with	with	IN
cord-349417-vn7q8wc4	140	8	molecular	molecular	JJ
cord-349417-vn7q8wc4	140	9	dynamics	dynamic	NNS
cord-349417-vn7q8wc4	140	10	simulations	simulation	NNS
cord-349417-vn7q8wc4	140	11	Conservation	Conservation	NNP
cord-349417-vn7q8wc4	140	12	of	of	IN
cord-349417-vn7q8wc4	140	13	substrate	substrate	NN
cord-349417-vn7q8wc4	140	14	specificities	specificity	NNS
cord-349417-vn7q8wc4	140	15	among	among	IN
cord-349417-vn7q8wc4	140	16	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	140	17	main	main	JJ
cord-349417-vn7q8wc4	140	18	proteases	protease	NNS
cord-349417-vn7q8wc4	141	1	The	the	DT
cord-349417-vn7q8wc4	141	2	crystal	crystal	NN
cord-349417-vn7q8wc4	141	3	structures	structure	NNS
cord-349417-vn7q8wc4	141	4	of	of	IN
cord-349417-vn7q8wc4	141	5	severe	severe	JJ
cord-349417-vn7q8wc4	141	6	acute	acute	JJ
cord-349417-vn7q8wc4	141	7	respiratory	respiratory	JJ
cord-349417-vn7q8wc4	141	8	syndrome	syndrome	NN
cord-349417-vn7q8wc4	141	9	virus	virus	NN
cord-349417-vn7q8wc4	141	10	main	main	JJ
cord-349417-vn7q8wc4	141	11	protease	protease	NN
cord-349417-vn7q8wc4	141	12	and	and	CC
cord-349417-vn7q8wc4	141	13	its	-PRON-	PRP$
cord-349417-vn7q8wc4	141	14	complex	complex	NN
cord-349417-vn7q8wc4	141	15	with	with	IN
cord-349417-vn7q8wc4	141	16	an	an	DT
cord-349417-vn7q8wc4	141	17	inhibitor	inhibitor	NN
cord-349417-vn7q8wc4	141	18	Design	design	NN
cord-349417-vn7q8wc4	141	19	of	of	IN
cord-349417-vn7q8wc4	141	20	wide	wide	JJ
cord-349417-vn7q8wc4	141	21	-	-	HYPH
cord-349417-vn7q8wc4	141	22	spectrum	spectrum	NN
cord-349417-vn7q8wc4	141	23	inhibitors	inhibitor	NNS
cord-349417-vn7q8wc4	141	24	targeting	target	VBG
cord-349417-vn7q8wc4	141	25	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	141	26	main	main	JJ
cord-349417-vn7q8wc4	141	27	proteases	protease	NNS
cord-349417-vn7q8wc4	141	28	Identification	identification	NN
cord-349417-vn7q8wc4	141	29	of	of	IN
cord-349417-vn7q8wc4	141	30	the	the	DT
cord-349417-vn7q8wc4	141	31	catalytic	catalytic	JJ
cord-349417-vn7q8wc4	141	32	sites	site	NNS
cord-349417-vn7q8wc4	141	33	of	of	IN
cord-349417-vn7q8wc4	141	34	a	a	DT
cord-349417-vn7q8wc4	141	35	papain	papain	NN
cord-349417-vn7q8wc4	141	36	-	-	HYPH
cord-349417-vn7q8wc4	141	37	like	like	JJ
cord-349417-vn7q8wc4	141	38	cysteine	cysteine	NN
cord-349417-vn7q8wc4	141	39	proteinase	proteinase	NN
cord-349417-vn7q8wc4	141	40	of	of	IN
cord-349417-vn7q8wc4	141	41	murine	murine	JJ
cord-349417-vn7q8wc4	141	42	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	141	43	Proteolytic	Proteolytic	NNP
cord-349417-vn7q8wc4	141	44	processing	processing	NN
cord-349417-vn7q8wc4	141	45	at	at	IN
cord-349417-vn7q8wc4	141	46	the	the	DT
cord-349417-vn7q8wc4	141	47	amino	amino	NN
cord-349417-vn7q8wc4	141	48	terminus	terminus	NN
cord-349417-vn7q8wc4	141	49	of	of	IN
cord-349417-vn7q8wc4	141	50	human	human	JJ
cord-349417-vn7q8wc4	141	51	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	141	52	229E	229e	CD
cord-349417-vn7q8wc4	141	53	gene	gene	NN
cord-349417-vn7q8wc4	141	54	1-encoded	1-encoded	CD
cord-349417-vn7q8wc4	141	55	polyproteins	polyprotein	NNS
cord-349417-vn7q8wc4	141	56	:	:	:
cord-349417-vn7q8wc4	141	57	identification	identification	NN
cord-349417-vn7q8wc4	141	58	of	of	IN
cord-349417-vn7q8wc4	141	59	a	a	DT
cord-349417-vn7q8wc4	141	60	papain	papain	NN
cord-349417-vn7q8wc4	141	61	-	-	HYPH
cord-349417-vn7q8wc4	141	62	like	like	JJ
cord-349417-vn7q8wc4	141	63	proteinase	proteinase	NN
cord-349417-vn7q8wc4	141	64	and	and	CC
cord-349417-vn7q8wc4	141	65	its	-PRON-	PRP$
cord-349417-vn7q8wc4	141	66	substrate	substrate	NN
cord-349417-vn7q8wc4	141	67	Characterization	characterization	NN
cord-349417-vn7q8wc4	141	68	of	of	IN
cord-349417-vn7q8wc4	141	69	the	the	DT
cord-349417-vn7q8wc4	141	70	two	two	CD
cord-349417-vn7q8wc4	141	71	overlapping	overlap	VBG
cord-349417-vn7q8wc4	141	72	papain	papain	NN
cord-349417-vn7q8wc4	141	73	-	-	HYPH
cord-349417-vn7q8wc4	141	74	like	like	JJ
cord-349417-vn7q8wc4	141	75	proteinase	proteinase	NN
cord-349417-vn7q8wc4	141	76	domains	domain	NNS
cord-349417-vn7q8wc4	141	77	encoded	encode	VBN
cord-349417-vn7q8wc4	141	78	in	in	IN
cord-349417-vn7q8wc4	141	79	gene	gene	NN
cord-349417-vn7q8wc4	141	80	1	1	CD
cord-349417-vn7q8wc4	141	81	of	of	IN
cord-349417-vn7q8wc4	141	82	the	the	DT
cord-349417-vn7q8wc4	141	83	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	141	84	infectious	infectious	JJ
cord-349417-vn7q8wc4	141	85	bronchitis	bronchitis	NN
cord-349417-vn7q8wc4	141	86	virus	virus	NN
cord-349417-vn7q8wc4	141	87	and	and	CC
cord-349417-vn7q8wc4	141	88	determination	determination	NN
cord-349417-vn7q8wc4	141	89	of	of	IN
cord-349417-vn7q8wc4	141	90	the	the	DT
cord-349417-vn7q8wc4	141	91	C	C	NNP
cord-349417-vn7q8wc4	141	92	-	-	HYPH
cord-349417-vn7q8wc4	141	93	terminal	terminal	NN
cord-349417-vn7q8wc4	141	94	cleavage	cleavage	NN
cord-349417-vn7q8wc4	141	95	site	site	NN
cord-349417-vn7q8wc4	141	96	of	of	IN
cord-349417-vn7q8wc4	141	97	an	an	DT
cord-349417-vn7q8wc4	141	98	87-kDa	87-kda	CD
cord-349417-vn7q8wc4	141	99	protein	protein	NN
cord-349417-vn7q8wc4	141	100	Identification	identification	NN
cord-349417-vn7q8wc4	141	101	of	of	IN
cord-349417-vn7q8wc4	141	102	mouse	mouse	NNP
cord-349417-vn7q8wc4	141	103	hepatitis	hepatitis	NNP
cord-349417-vn7q8wc4	141	104	virus	virus	NN
cord-349417-vn7q8wc4	141	105	papain	papain	NN
cord-349417-vn7q8wc4	141	106	-	-	HYPH
cord-349417-vn7q8wc4	141	107	like	like	JJ
cord-349417-vn7q8wc4	141	108	proteinase	proteinase	NN
cord-349417-vn7q8wc4	141	109	2	2	CD
cord-349417-vn7q8wc4	141	110	activity	activity	NN
cord-349417-vn7q8wc4	141	111	Identification	identification	NN
cord-349417-vn7q8wc4	141	112	of	of	IN
cord-349417-vn7q8wc4	141	113	a	a	DT
cord-349417-vn7q8wc4	141	114	novel	novel	JJ
cord-349417-vn7q8wc4	141	115	cleavage	cleavage	NN
cord-349417-vn7q8wc4	141	116	activity	activity	NN
cord-349417-vn7q8wc4	141	117	of	of	IN
cord-349417-vn7q8wc4	141	118	the	the	DT
cord-349417-vn7q8wc4	141	119	first	first	JJ
cord-349417-vn7q8wc4	141	120	papain	papain	NN
cord-349417-vn7q8wc4	141	121	-	-	HYPH
cord-349417-vn7q8wc4	141	122	like	like	JJ
cord-349417-vn7q8wc4	141	123	proteinase	proteinase	NN
cord-349417-vn7q8wc4	141	124	domain	domain	NN
cord-349417-vn7q8wc4	141	125	encoded	encode	VBN
cord-349417-vn7q8wc4	141	126	by	by	IN
cord-349417-vn7q8wc4	141	127	open	open	JJ
cord-349417-vn7q8wc4	141	128	reading	reading	NN
cord-349417-vn7q8wc4	141	129	frame	frame	NN
cord-349417-vn7q8wc4	141	130	1a	1a	CD
cord-349417-vn7q8wc4	141	131	of	of	IN
cord-349417-vn7q8wc4	141	132	the	the	DT
cord-349417-vn7q8wc4	141	133	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	142	1	Avian	avian	JJ
cord-349417-vn7q8wc4	142	2	infectious	infectious	JJ
cord-349417-vn7q8wc4	142	3	bronchitis	bronchitis	NN
cord-349417-vn7q8wc4	142	4	virus	virus	NN
cord-349417-vn7q8wc4	142	5	and	and	CC
cord-349417-vn7q8wc4	142	6	characterization	characterization	NN
cord-349417-vn7q8wc4	142	7	of	of	IN
cord-349417-vn7q8wc4	142	8	the	the	DT
cord-349417-vn7q8wc4	142	9	cleavage	cleavage	NN
cord-349417-vn7q8wc4	142	10	products	product	NNS
cord-349417-vn7q8wc4	143	1	The	the	DT
cord-349417-vn7q8wc4	143	2	autocatalytic	autocatalytic	JJ
cord-349417-vn7q8wc4	143	3	release	release	NN
cord-349417-vn7q8wc4	143	4	of	of	IN
cord-349417-vn7q8wc4	143	5	a	a	DT
cord-349417-vn7q8wc4	143	6	putative	putative	JJ
cord-349417-vn7q8wc4	143	7	RNA	RNA	NNP
cord-349417-vn7q8wc4	143	8	virus	virus	NN
cord-349417-vn7q8wc4	143	9	transcription	transcription	NN
cord-349417-vn7q8wc4	143	10	factor	factor	NN
cord-349417-vn7q8wc4	143	11	from	from	IN
cord-349417-vn7q8wc4	143	12	its	-PRON-	PRP$
cord-349417-vn7q8wc4	143	13	polyprotein	polyprotein	JJ
cord-349417-vn7q8wc4	143	14	precursor	precursor	NN
cord-349417-vn7q8wc4	143	15	involves	involve	VBZ
cord-349417-vn7q8wc4	143	16	two	two	CD
cord-349417-vn7q8wc4	143	17	paralogous	paralogous	JJ
cord-349417-vn7q8wc4	143	18	papain	papain	NN
cord-349417-vn7q8wc4	143	19	-	-	HYPH
cord-349417-vn7q8wc4	143	20	like	like	JJ
cord-349417-vn7q8wc4	143	21	proteases	protease	NNS
cord-349417-vn7q8wc4	143	22	that	that	WDT
cord-349417-vn7q8wc4	143	23	cleave	cleave	VBP
cord-349417-vn7q8wc4	143	24	the	the	DT
cord-349417-vn7q8wc4	143	25	same	same	JJ
cord-349417-vn7q8wc4	143	26	peptide	peptide	NN
cord-349417-vn7q8wc4	143	27	bond	bond	NN
cord-349417-vn7q8wc4	143	28	Mechanisms	mechanism	NNS
cord-349417-vn7q8wc4	143	29	and	and	CC
cord-349417-vn7q8wc4	143	30	enzymes	enzyme	NNS
cord-349417-vn7q8wc4	143	31	involved	involve	VBN
cord-349417-vn7q8wc4	143	32	in	in	IN
cord-349417-vn7q8wc4	143	33	SARS	SARS	NNP
cord-349417-vn7q8wc4	143	34	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	143	35	genome	genome	NN
cord-349417-vn7q8wc4	143	36	expression	expression	NN
cord-349417-vn7q8wc4	143	37	Identification	identification	NN
cord-349417-vn7q8wc4	143	38	of	of	IN
cord-349417-vn7q8wc4	143	39	severe	severe	JJ
cord-349417-vn7q8wc4	143	40	acute	acute	JJ
cord-349417-vn7q8wc4	143	41	respiratory	respiratory	JJ
cord-349417-vn7q8wc4	143	42	syndrome	syndrome	NN
cord-349417-vn7q8wc4	143	43	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	143	44	replicase	replicase	NN
cord-349417-vn7q8wc4	143	45	products	product	NNS
cord-349417-vn7q8wc4	143	46	and	and	CC
cord-349417-vn7q8wc4	143	47	characterization	characterization	NN
cord-349417-vn7q8wc4	143	48	of	of	IN
cord-349417-vn7q8wc4	143	49	papain	papain	NN
cord-349417-vn7q8wc4	143	50	-	-	HYPH
cord-349417-vn7q8wc4	143	51	like	like	JJ
cord-349417-vn7q8wc4	143	52	protease	protease	NN
cord-349417-vn7q8wc4	143	53	activity	activity	NN
cord-349417-vn7q8wc4	144	1	Papain	papain	NN
cord-349417-vn7q8wc4	144	2	-	-	HYPH
cord-349417-vn7q8wc4	144	3	like	like	JJ
cord-349417-vn7q8wc4	144	4	protease	protease	NN
cord-349417-vn7q8wc4	144	5	2	2	CD
cord-349417-vn7q8wc4	144	6	(	(	-LRB-
cord-349417-vn7q8wc4	144	7	PLP2	PLP2	NNP
cord-349417-vn7q8wc4	144	8	)	)	-RRB-
cord-349417-vn7q8wc4	144	9	from	from	IN
cord-349417-vn7q8wc4	144	10	severe	severe	JJ
cord-349417-vn7q8wc4	144	11	acute	acute	JJ
cord-349417-vn7q8wc4	144	12	respiratory	respiratory	JJ
cord-349417-vn7q8wc4	144	13	syndrome	syndrome	NN
cord-349417-vn7q8wc4	144	14	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	144	15	(	(	-LRB-
cord-349417-vn7q8wc4	144	16	SARS	SARS	NNP
cord-349417-vn7q8wc4	144	17	-	-	HYPH
cord-349417-vn7q8wc4	144	18	CoV	CoV	NNP
cord-349417-vn7q8wc4	144	19	)	)	-RRB-
cord-349417-vn7q8wc4	144	20	:	:	:
cord-349417-vn7q8wc4	144	21	expression	expression	NN
cord-349417-vn7q8wc4	144	22	,	,	,
cord-349417-vn7q8wc4	144	23	purification	purification	NN
cord-349417-vn7q8wc4	144	24	,	,	,
cord-349417-vn7q8wc4	144	25	characterization	characterization	NN
cord-349417-vn7q8wc4	144	26	,	,	,
cord-349417-vn7q8wc4	144	27	and	and	CC
cord-349417-vn7q8wc4	144	28	inhibition	inhibition	NN
cord-349417-vn7q8wc4	144	29	Cleavage	cleavage	NN
cord-349417-vn7q8wc4	144	30	between	between	IN
cord-349417-vn7q8wc4	144	31	replicase	replicase	NN
cord-349417-vn7q8wc4	144	32	proteins	protein	NNS
cord-349417-vn7q8wc4	144	33	p28	p28	CD
cord-349417-vn7q8wc4	144	34	and	and	CC
cord-349417-vn7q8wc4	144	35	p65	p65	NN
cord-349417-vn7q8wc4	144	36	of	of	IN
cord-349417-vn7q8wc4	144	37	mouse	mouse	NNP
cord-349417-vn7q8wc4	144	38	hepatitis	hepatitis	NNP
cord-349417-vn7q8wc4	144	39	virus	virus	NN
cord-349417-vn7q8wc4	144	40	is	be	VBZ
cord-349417-vn7q8wc4	144	41	not	not	RB
cord-349417-vn7q8wc4	144	42	required	require	VBN
cord-349417-vn7q8wc4	144	43	for	for	IN
cord-349417-vn7q8wc4	144	44	virus	virus	NN
cord-349417-vn7q8wc4	144	45	replication	replication	NN
cord-349417-vn7q8wc4	144	46	Mutagenesis	Mutagenesis	NNP
cord-349417-vn7q8wc4	144	47	of	of	IN
cord-349417-vn7q8wc4	144	48	the	the	DT
cord-349417-vn7q8wc4	144	49	murine	murine	JJ
cord-349417-vn7q8wc4	144	50	hepatitis	hepatitis	NN
cord-349417-vn7q8wc4	144	51	virus	virus	NN
cord-349417-vn7q8wc4	145	1	nsp1-coding	nsp1-coding	NN
cord-349417-vn7q8wc4	145	2	region	region	NN
cord-349417-vn7q8wc4	145	3	identifies	identify	VBZ
cord-349417-vn7q8wc4	145	4	residues	residue	NNS
cord-349417-vn7q8wc4	145	5	important	important	JJ
cord-349417-vn7q8wc4	145	6	for	for	IN
cord-349417-vn7q8wc4	145	7	protein	protein	NN
cord-349417-vn7q8wc4	145	8	processing	processing	NN
cord-349417-vn7q8wc4	145	9	,	,	,
cord-349417-vn7q8wc4	145	10	viral	viral	JJ
cord-349417-vn7q8wc4	145	11	RNA	RNA	NNP
cord-349417-vn7q8wc4	145	12	synthesis	synthesis	NN
cord-349417-vn7q8wc4	145	13	,	,	,
cord-349417-vn7q8wc4	145	14	and	and	CC
cord-349417-vn7q8wc4	145	15	viral	viral	JJ
cord-349417-vn7q8wc4	145	16	replication	replication	NN
cord-349417-vn7q8wc4	146	1	The	the	DT
cord-349417-vn7q8wc4	146	2	nsp2	nsp2	NNP
cord-349417-vn7q8wc4	146	3	replicase	replicase	NN
cord-349417-vn7q8wc4	146	4	proteins	protein	NNS
cord-349417-vn7q8wc4	146	5	of	of	IN
cord-349417-vn7q8wc4	146	6	murine	murine	JJ
cord-349417-vn7q8wc4	146	7	hepatitis	hepatitis	NN
cord-349417-vn7q8wc4	146	8	virus	virus	NN
cord-349417-vn7q8wc4	146	9	and	and	CC
cord-349417-vn7q8wc4	146	10	severe	severe	JJ
cord-349417-vn7q8wc4	146	11	acute	acute	JJ
cord-349417-vn7q8wc4	146	12	respiratory	respiratory	JJ
cord-349417-vn7q8wc4	146	13	syndrome	syndrome	NN
cord-349417-vn7q8wc4	146	14	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	146	15	are	be	VBP
cord-349417-vn7q8wc4	146	16	dispensable	dispensable	JJ
cord-349417-vn7q8wc4	146	17	for	for	IN
cord-349417-vn7q8wc4	146	18	viral	viral	JJ
cord-349417-vn7q8wc4	146	19	replication	replication	NN
cord-349417-vn7q8wc4	147	1	The	the	DT
cord-349417-vn7q8wc4	147	2	phylogeny	phylogeny	NN
cord-349417-vn7q8wc4	147	3	of	of	IN
cord-349417-vn7q8wc4	147	4	RNA	rna	NN
cord-349417-vn7q8wc4	147	5	-	-	HYPH
cord-349417-vn7q8wc4	147	6	dependent	dependent	JJ
cord-349417-vn7q8wc4	147	7	RNA	RNA	NNP
cord-349417-vn7q8wc4	147	8	polymerases	polymerase	NNS
cord-349417-vn7q8wc4	147	9	of	of	IN
cord-349417-vn7q8wc4	147	10	positive	positive	JJ
cord-349417-vn7q8wc4	147	11	-	-	HYPH
cord-349417-vn7q8wc4	147	12	strand	strand	NN
cord-349417-vn7q8wc4	147	13	RNA	RNA	NNP
cord-349417-vn7q8wc4	147	14	viruses	virus	NNS
cord-349417-vn7q8wc4	147	15	Expression	expression	NN
cord-349417-vn7q8wc4	147	16	,	,	,
cord-349417-vn7q8wc4	147	17	purification	purification	NN
cord-349417-vn7q8wc4	147	18	,	,	,
cord-349417-vn7q8wc4	147	19	and	and	CC
cord-349417-vn7q8wc4	147	20	characterization	characterization	NN
cord-349417-vn7q8wc4	147	21	of	of	IN
cord-349417-vn7q8wc4	147	22	SARS	SARS	NNP
cord-349417-vn7q8wc4	147	23	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	147	24	RNA	RNA	NNP
cord-349417-vn7q8wc4	147	25	polymerase	polymerase	NN
cord-349417-vn7q8wc4	147	26	Characterization	characterization	NN
cord-349417-vn7q8wc4	147	27	of	of	IN
cord-349417-vn7q8wc4	147	28	the	the	DT
cord-349417-vn7q8wc4	147	29	expression	expression	NN
cord-349417-vn7q8wc4	147	30	,	,	,
cord-349417-vn7q8wc4	147	31	intracellular	intracellular	JJ
cord-349417-vn7q8wc4	147	32	localization	localization	NN
cord-349417-vn7q8wc4	147	33	,	,	,
cord-349417-vn7q8wc4	147	34	and	and	CC
cord-349417-vn7q8wc4	147	35	replication	replication	NN
cord-349417-vn7q8wc4	147	36	complex	complex	NNP
cord-349417-vn7q8wc4	147	37	association	association	NNP
cord-349417-vn7q8wc4	147	38	of	of	IN
cord-349417-vn7q8wc4	147	39	the	the	DT
cord-349417-vn7q8wc4	147	40	putative	putative	JJ
cord-349417-vn7q8wc4	147	41	mouse	mouse	NN
cord-349417-vn7q8wc4	147	42	hepatitis	hepatitis	NNP
cord-349417-vn7q8wc4	147	43	virus	virus	NN
cord-349417-vn7q8wc4	147	44	RNAdependent	RNAdependent	NNP
cord-349417-vn7q8wc4	147	45	RNA	RNA	NNP
cord-349417-vn7q8wc4	147	46	polymerase	polymerase	NN
cord-349417-vn7q8wc4	147	47	Insights	insight	NNS
cord-349417-vn7q8wc4	147	48	into	into	IN
cord-349417-vn7q8wc4	147	49	SARS	SARS	NNP
cord-349417-vn7q8wc4	147	50	-	-	HYPH
cord-349417-vn7q8wc4	147	51	CoV	CoV	NNP
cord-349417-vn7q8wc4	147	52	transcription	transcription	NN
cord-349417-vn7q8wc4	147	53	and	and	CC
cord-349417-vn7q8wc4	147	54	replication	replication	NN
cord-349417-vn7q8wc4	147	55	from	from	IN
cord-349417-vn7q8wc4	147	56	the	the	DT
cord-349417-vn7q8wc4	147	57	structure	structure	NN
cord-349417-vn7q8wc4	147	58	of	of	IN
cord-349417-vn7q8wc4	147	59	the	the	DT
cord-349417-vn7q8wc4	147	60	nsp7-nsp8	nsp7-nsp8	NNP
cord-349417-vn7q8wc4	147	61	hexadecamer	hexadecamer	NN
cord-349417-vn7q8wc4	148	1	The	the	DT
cord-349417-vn7q8wc4	148	2	severe	severe	JJ
cord-349417-vn7q8wc4	148	3	acute	acute	JJ
cord-349417-vn7q8wc4	148	4	respiratory	respiratory	JJ
cord-349417-vn7q8wc4	148	5	syndrome	syndrome	NN
cord-349417-vn7q8wc4	148	6	-	-	HYPH
cord-349417-vn7q8wc4	148	7	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	148	8	replicative	replicative	JJ
cord-349417-vn7q8wc4	148	9	protein	protein	NN
cord-349417-vn7q8wc4	148	10	nsp9	nsp9	NN
cord-349417-vn7q8wc4	148	11	is	be	VBZ
cord-349417-vn7q8wc4	148	12	a	a	DT
cord-349417-vn7q8wc4	148	13	single	single	RB
cord-349417-vn7q8wc4	148	14	-	-	HYPH
cord-349417-vn7q8wc4	148	15	stranded	strand	VBN
cord-349417-vn7q8wc4	148	16	RNA	rna	NN
cord-349417-vn7q8wc4	148	17	-	-	HYPH
cord-349417-vn7q8wc4	148	18	binding	bind	VBG
cord-349417-vn7q8wc4	148	19	subunit	subunit	NN
cord-349417-vn7q8wc4	148	20	unique	unique	JJ
cord-349417-vn7q8wc4	148	21	in	in	IN
cord-349417-vn7q8wc4	148	22	the	the	DT
cord-349417-vn7q8wc4	148	23	RNA	RNA	NNP
cord-349417-vn7q8wc4	148	24	virus	virus	NN
cord-349417-vn7q8wc4	148	25	world	world	NN
cord-349417-vn7q8wc4	149	1	The	the	DT
cord-349417-vn7q8wc4	149	2	nsp9	nsp9	DT
cord-349417-vn7q8wc4	149	3	replicase	replicase	NN
cord-349417-vn7q8wc4	149	4	protein	protein	NN
cord-349417-vn7q8wc4	149	5	of	of	IN
cord-349417-vn7q8wc4	149	6	SARS	SARS	NNP
cord-349417-vn7q8wc4	149	7	-	-	HYPH
cord-349417-vn7q8wc4	149	8	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	149	9	,	,	,
cord-349417-vn7q8wc4	149	10	structure	structure	NN
cord-349417-vn7q8wc4	149	11	and	and	CC
cord-349417-vn7q8wc4	149	12	functional	functional	JJ
cord-349417-vn7q8wc4	149	13	insights	insight	NNS
cord-349417-vn7q8wc4	149	14	Identification	Identification	NNP
cord-349417-vn7q8wc4	149	15	of	of	IN
cord-349417-vn7q8wc4	149	16	the	the	DT
cord-349417-vn7q8wc4	149	17	mutations	mutation	NNS
cord-349417-vn7q8wc4	149	18	responsible	responsible	JJ
cord-349417-vn7q8wc4	149	19	for	for	IN
cord-349417-vn7q8wc4	149	20	the	the	DT
cord-349417-vn7q8wc4	149	21	phenotype	phenotype	NN
cord-349417-vn7q8wc4	149	22	of	of	IN
cord-349417-vn7q8wc4	149	23	three	three	CD
cord-349417-vn7q8wc4	149	24	MHV	MHV	NNP
cord-349417-vn7q8wc4	149	25	RNA	RNA	NNP
cord-349417-vn7q8wc4	149	26	-	-	HYPH
cord-349417-vn7q8wc4	149	27	negative	negative	JJ
cord-349417-vn7q8wc4	149	28	ts	ts	NN
cord-349417-vn7q8wc4	149	29	mutants	mutant	NNS
cord-349417-vn7q8wc4	149	30	Two	two	CD
cord-349417-vn7q8wc4	149	31	related	related	JJ
cord-349417-vn7q8wc4	149	32	superfamilies	superfamily	NNS
cord-349417-vn7q8wc4	149	33	of	of	IN
cord-349417-vn7q8wc4	149	34	putative	putative	JJ
cord-349417-vn7q8wc4	149	35	helicases	helicase	NNS
cord-349417-vn7q8wc4	149	36	involved	involve	VBN
cord-349417-vn7q8wc4	149	37	in	in	IN
cord-349417-vn7q8wc4	149	38	replication	replication	NN
cord-349417-vn7q8wc4	149	39	,	,	,
cord-349417-vn7q8wc4	149	40	recombination	recombination	NN
cord-349417-vn7q8wc4	149	41	,	,	,
cord-349417-vn7q8wc4	149	42	repair	repair	NN
cord-349417-vn7q8wc4	149	43	and	and	CC
cord-349417-vn7q8wc4	149	44	expression	expression	NN
cord-349417-vn7q8wc4	149	45	of	of	IN
cord-349417-vn7q8wc4	149	46	DNA	DNA	NNP
cord-349417-vn7q8wc4	149	47	and	and	CC
cord-349417-vn7q8wc4	149	48	RNA	RNA	NNP
cord-349417-vn7q8wc4	149	49	genomes	genome	NNS
cord-349417-vn7q8wc4	150	1	The	the	DT
cord-349417-vn7q8wc4	150	2	human	human	JJ
cord-349417-vn7q8wc4	150	3	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	150	4	229E	229e	CD
cord-349417-vn7q8wc4	150	5	superfamily	superfamily	NN
cord-349417-vn7q8wc4	150	6	1	1	CD
cord-349417-vn7q8wc4	150	7	helicase	helicase	NNP
cord-349417-vn7q8wc4	150	8	has	have	VBZ
cord-349417-vn7q8wc4	150	9	RNA	RNA	NNP
cord-349417-vn7q8wc4	150	10	and	and	CC
cord-349417-vn7q8wc4	150	11	DNA	dna	NN
cord-349417-vn7q8wc4	150	12	duplex	duplex	NN
cord-349417-vn7q8wc4	150	13	-	-	HYPH
cord-349417-vn7q8wc4	150	14	unwinding	unwind	VBG
cord-349417-vn7q8wc4	150	15	activities	activity	NNS
cord-349417-vn7q8wc4	150	16	with	with	IN
cord-349417-vn7q8wc4	150	17	5'-to-3	5'-to-3	CD
cord-349417-vn7q8wc4	150	18	'	'	``
cord-349417-vn7q8wc4	150	19	polarity	polarity	NN
cord-349417-vn7q8wc4	150	20	Guanosine	Guanosine	NNP
cord-349417-vn7q8wc4	150	21	triphosphatase	triphosphatase	NN
cord-349417-vn7q8wc4	150	22	activity	activity	NN
cord-349417-vn7q8wc4	150	23	of	of	IN
cord-349417-vn7q8wc4	150	24	the	the	DT
cord-349417-vn7q8wc4	150	25	human	human	JJ
cord-349417-vn7q8wc4	150	26	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	151	1	helicase	helicase	NNP
cord-349417-vn7q8wc4	152	1	The	the	DT
cord-349417-vn7q8wc4	152	2	severe	severe	JJ
cord-349417-vn7q8wc4	152	3	acute	acute	JJ
cord-349417-vn7q8wc4	152	4	respiratory	respiratory	JJ
cord-349417-vn7q8wc4	152	5	syndrome	syndrome	NN
cord-349417-vn7q8wc4	152	6	(	(	-LRB-
cord-349417-vn7q8wc4	152	7	SARS	SARS	NNP
cord-349417-vn7q8wc4	152	8	)	)	-RRB-
cord-349417-vn7q8wc4	152	9	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	153	1	NTPase	NTPase	NNP
cord-349417-vn7q8wc4	153	2	/	/	SYM
cord-349417-vn7q8wc4	153	3	helicase	helicase	NNP
cord-349417-vn7q8wc4	153	4	belongs	belong	VBZ
cord-349417-vn7q8wc4	153	5	to	to	IN
cord-349417-vn7q8wc4	153	6	a	a	DT
cord-349417-vn7q8wc4	153	7	distinct	distinct	JJ
cord-349417-vn7q8wc4	153	8	class	class	NN
cord-349417-vn7q8wc4	153	9	of	of	IN
cord-349417-vn7q8wc4	153	10	5	5	CD
cord-349417-vn7q8wc4	153	11	'	'	''
cord-349417-vn7q8wc4	153	12	to	to	IN
cord-349417-vn7q8wc4	153	13	3	3	CD
cord-349417-vn7q8wc4	153	14	'	'	''
cord-349417-vn7q8wc4	153	15	viral	viral	JJ
cord-349417-vn7q8wc4	153	16	helicases	helicase	NNS
cord-349417-vn7q8wc4	154	1	Multiple	multiple	JJ
cord-349417-vn7q8wc4	154	2	enzymatic	enzymatic	JJ
cord-349417-vn7q8wc4	154	3	activities	activity	NNS
cord-349417-vn7q8wc4	154	4	associated	associate	VBN
cord-349417-vn7q8wc4	154	5	with	with	IN
cord-349417-vn7q8wc4	154	6	severe	severe	JJ
cord-349417-vn7q8wc4	154	7	acute	acute	JJ
cord-349417-vn7q8wc4	154	8	respiratory	respiratory	JJ
cord-349417-vn7q8wc4	154	9	syndrome	syndrome	NN
cord-349417-vn7q8wc4	154	10	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	154	11	helicase	helicase	NN
cord-349417-vn7q8wc4	154	12	Human	human	JJ
cord-349417-vn7q8wc4	154	13	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	154	14	229E	229e	CD
cord-349417-vn7q8wc4	154	15	nonstructural	nonstructural	JJ
cord-349417-vn7q8wc4	154	16	protein	protein	NNP
cord-349417-vn7q8wc4	154	17	13	13	CD
cord-349417-vn7q8wc4	154	18	:	:	:
cord-349417-vn7q8wc4	154	19	characterization	characterization	NN
cord-349417-vn7q8wc4	154	20	of	of	IN
cord-349417-vn7q8wc4	154	21	duplex	duplex	NN
cord-349417-vn7q8wc4	154	22	-	-	HYPH
cord-349417-vn7q8wc4	154	23	unwinding	unwinding	NN
cord-349417-vn7q8wc4	154	24	,	,	,
cord-349417-vn7q8wc4	154	25	nucleoside	nucleoside	RB
cord-349417-vn7q8wc4	154	26	triphosphatase	triphosphatase	NN
cord-349417-vn7q8wc4	154	27	,	,	,
cord-349417-vn7q8wc4	154	28	and	and	CC
cord-349417-vn7q8wc4	154	29	RNA	RNA	NNP
cord-349417-vn7q8wc4	154	30	5'-triphosphatase	5'-triphosphatase	CD
cord-349417-vn7q8wc4	154	31	activities	activity	NNS
cord-349417-vn7q8wc4	155	1	A	a	DT
cord-349417-vn7q8wc4	155	2	complex	complex	JJ
cord-349417-vn7q8wc4	155	3	zinc	zinc	NN
cord-349417-vn7q8wc4	155	4	finger	finger	NN
cord-349417-vn7q8wc4	155	5	controls	control	VBZ
cord-349417-vn7q8wc4	155	6	the	the	DT
cord-349417-vn7q8wc4	155	7	enzymatic	enzymatic	JJ
cord-349417-vn7q8wc4	155	8	activities	activity	NNS
cord-349417-vn7q8wc4	155	9	of	of	IN
cord-349417-vn7q8wc4	155	10	nidovirus	nidovirus	NNP
cord-349417-vn7q8wc4	155	11	helicases	helicase	NNS
cord-349417-vn7q8wc4	155	12	Biochemical	biochemical	JJ
cord-349417-vn7q8wc4	155	13	characterization	characterization	NN
cord-349417-vn7q8wc4	155	14	of	of	IN
cord-349417-vn7q8wc4	155	15	the	the	DT
cord-349417-vn7q8wc4	155	16	equine	equine	JJ
cord-349417-vn7q8wc4	155	17	arteritis	arteritis	NN
cord-349417-vn7q8wc4	155	18	virus	virus	NN
cord-349417-vn7q8wc4	155	19	helicase	helicase	NNP
cord-349417-vn7q8wc4	156	1	suggests	suggest	VBZ
cord-349417-vn7q8wc4	156	2	a	a	DT
cord-349417-vn7q8wc4	156	3	close	close	JJ
cord-349417-vn7q8wc4	156	4	functional	functional	JJ
cord-349417-vn7q8wc4	156	5	relationship	relationship	NN
cord-349417-vn7q8wc4	156	6	between	between	IN
cord-349417-vn7q8wc4	156	7	arterivirus	arterivirus	NN
cord-349417-vn7q8wc4	156	8	and	and	CC
cord-349417-vn7q8wc4	156	9	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	156	10	helicases	helicase	NNS
cord-349417-vn7q8wc4	156	11	Virus	Virus	NNP
cord-349417-vn7q8wc4	156	12	-	-	HYPH
cord-349417-vn7q8wc4	156	13	encoded	encode	VBN
cord-349417-vn7q8wc4	156	14	RNA	RNA	NNP
cord-349417-vn7q8wc4	156	15	helicases	helicase	NNS
cord-349417-vn7q8wc4	156	16	The	the	DT
cord-349417-vn7q8wc4	156	17	predicted	predict	VBN
cord-349417-vn7q8wc4	156	18	metal	metal	NN
cord-349417-vn7q8wc4	156	19	-	-	HYPH
cord-349417-vn7q8wc4	156	20	binding	bind	VBG
cord-349417-vn7q8wc4	156	21	region	region	NN
cord-349417-vn7q8wc4	156	22	of	of	IN
cord-349417-vn7q8wc4	156	23	the	the	DT
cord-349417-vn7q8wc4	156	24	arterivirus	arterivirus	NNP
cord-349417-vn7q8wc4	156	25	helicase	helicase	NNP
cord-349417-vn7q8wc4	156	26	protein	protein	NN
cord-349417-vn7q8wc4	156	27	is	be	VBZ
cord-349417-vn7q8wc4	156	28	involved	involve	VBN
cord-349417-vn7q8wc4	156	29	in	in	IN
cord-349417-vn7q8wc4	156	30	subgenomic	subgenomic	NNP
cord-349417-vn7q8wc4	156	31	mRNA	mRNA	NNP
cord-349417-vn7q8wc4	156	32	synthesis	synthesis	NNP
cord-349417-vn7q8wc4	156	33	,	,	,
cord-349417-vn7q8wc4	156	34	genome	genome	NN
cord-349417-vn7q8wc4	156	35	replication	replication	NN
cord-349417-vn7q8wc4	156	36	,	,	,
cord-349417-vn7q8wc4	156	37	and	and	CC
cord-349417-vn7q8wc4	156	38	virion	virion	NN
cord-349417-vn7q8wc4	156	39	biogenesis	biogenesis	NN
cord-349417-vn7q8wc4	157	1	The	the	DT
cord-349417-vn7q8wc4	157	2	severe	severe	JJ
cord-349417-vn7q8wc4	157	3	acute	acute	JJ
cord-349417-vn7q8wc4	157	4	respiratory	respiratory	JJ
cord-349417-vn7q8wc4	157	5	syndrome	syndrome	NN
cord-349417-vn7q8wc4	157	6	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	158	1	Nsp15	Nsp15	NNP
cord-349417-vn7q8wc4	158	2	protein	protein	NN
cord-349417-vn7q8wc4	158	3	is	be	VBZ
cord-349417-vn7q8wc4	158	4	an	an	DT
cord-349417-vn7q8wc4	158	5	endoribonuclease	endoribonuclease	NN
cord-349417-vn7q8wc4	158	6	that	that	WDT
cord-349417-vn7q8wc4	158	7	prefers	prefer	VBZ
cord-349417-vn7q8wc4	158	8	manganese	manganese	NN
cord-349417-vn7q8wc4	158	9	as	as	IN
cord-349417-vn7q8wc4	158	10	a	a	DT
cord-349417-vn7q8wc4	158	11	cofactor	cofactor	NN
cord-349417-vn7q8wc4	158	12	Major	major	JJ
cord-349417-vn7q8wc4	158	13	genetic	genetic	JJ
cord-349417-vn7q8wc4	158	14	marker	marker	NN
cord-349417-vn7q8wc4	158	15	of	of	IN
cord-349417-vn7q8wc4	158	16	nidoviruses	nidoviruses	NNP
cord-349417-vn7q8wc4	158	17	encodes	encode	VBZ
cord-349417-vn7q8wc4	158	18	a	a	DT
cord-349417-vn7q8wc4	158	19	replicative	replicative	JJ
cord-349417-vn7q8wc4	158	20	endoribonuclease	endoribonuclease	NN
cord-349417-vn7q8wc4	159	1	The	the	DT
cord-349417-vn7q8wc4	159	2	carboxyl	carboxyl	NN
cord-349417-vn7q8wc4	159	3	-	-	HYPH
cord-349417-vn7q8wc4	159	4	terminal	terminal	NN
cord-349417-vn7q8wc4	159	5	part	part	NN
cord-349417-vn7q8wc4	159	6	of	of	IN
cord-349417-vn7q8wc4	159	7	the	the	DT
cord-349417-vn7q8wc4	159	8	putative	putative	JJ
cord-349417-vn7q8wc4	159	9	Berne	Berne	NNP
cord-349417-vn7q8wc4	159	10	virus	virus	NN
cord-349417-vn7q8wc4	159	11	polymerase	polymerase	NN
cord-349417-vn7q8wc4	159	12	is	be	VBZ
cord-349417-vn7q8wc4	159	13	expressed	express	VBN
cord-349417-vn7q8wc4	159	14	by	by	IN
cord-349417-vn7q8wc4	159	15	ribosomal	ribosomal	JJ
cord-349417-vn7q8wc4	159	16	frameshifting	frameshifting	NN
cord-349417-vn7q8wc4	159	17	and	and	CC
cord-349417-vn7q8wc4	159	18	contains	contain	VBZ
cord-349417-vn7q8wc4	159	19	sequence	sequence	NN
cord-349417-vn7q8wc4	159	20	motifs	motif	NNS
cord-349417-vn7q8wc4	159	21	which	which	WDT
cord-349417-vn7q8wc4	159	22	indicate	indicate	VBP
cord-349417-vn7q8wc4	159	23	that	that	IN
cord-349417-vn7q8wc4	159	24	toro	toro	NN
cord-349417-vn7q8wc4	159	25	-	-	HYPH
cord-349417-vn7q8wc4	159	26	and	and	CC
cord-349417-vn7q8wc4	159	27	coronaviruses	coronaviruse	NNS
cord-349417-vn7q8wc4	159	28	are	be	VBP
cord-349417-vn7q8wc4	159	29	evolutionarily	evolutionarily	RB
cord-349417-vn7q8wc4	159	30	related	relate	VBN
cord-349417-vn7q8wc4	159	31	Equine	equine	JJ
cord-349417-vn7q8wc4	159	32	arteritis	arteritis	NN
cord-349417-vn7q8wc4	159	33	virus	virus	NN
cord-349417-vn7q8wc4	159	34	is	be	VBZ
cord-349417-vn7q8wc4	159	35	not	not	RB
cord-349417-vn7q8wc4	159	36	a	a	DT
cord-349417-vn7q8wc4	159	37	togavirus	togavirus	NN
cord-349417-vn7q8wc4	159	38	but	but	CC
cord-349417-vn7q8wc4	159	39	belongs	belong	VBZ
cord-349417-vn7q8wc4	159	40	to	to	IN
cord-349417-vn7q8wc4	159	41	the	the	DT
cord-349417-vn7q8wc4	159	42	coronaviruslike	coronaviruslike	JJ
cord-349417-vn7q8wc4	159	43	superfamily	superfamily	NN
cord-349417-vn7q8wc4	159	44	ADP	ADP	NNP
cord-349417-vn7q8wc4	159	45	-	-	HYPH
cord-349417-vn7q8wc4	159	46	ribose-1"-monophosphatase	ribose-1"-monophosphatase	NNP
cord-349417-vn7q8wc4	159	47	:	:	:
cord-349417-vn7q8wc4	159	48	a	a	DT
cord-349417-vn7q8wc4	159	49	conserved	conserve	VBN
cord-349417-vn7q8wc4	159	50	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	159	51	enzyme	enzyme	NN
cord-349417-vn7q8wc4	159	52	that	that	WDT
cord-349417-vn7q8wc4	159	53	is	be	VBZ
cord-349417-vn7q8wc4	159	54	dispensable	dispensable	JJ
cord-349417-vn7q8wc4	159	55	for	for	IN
cord-349417-vn7q8wc4	159	56	viral	viral	JJ
cord-349417-vn7q8wc4	159	57	replication	replication	NN
cord-349417-vn7q8wc4	159	58	in	in	IN
cord-349417-vn7q8wc4	159	59	tissue	tissue	NN
cord-349417-vn7q8wc4	159	60	culture	culture	NN
cord-349417-vn7q8wc4	159	61	Single	single	JJ
cord-349417-vn7q8wc4	159	62	-	-	HYPH
cord-349417-vn7q8wc4	159	63	aminoacid	aminoacid	JJ
cord-349417-vn7q8wc4	159	64	substitutions	substitution	NNS
cord-349417-vn7q8wc4	159	65	in	in	IN
cord-349417-vn7q8wc4	159	66	open	open	JJ
cord-349417-vn7q8wc4	159	67	reading	reading	NN
cord-349417-vn7q8wc4	159	68	frame	frame	NN
cord-349417-vn7q8wc4	159	69	(	(	-LRB-
cord-349417-vn7q8wc4	159	70	ORF	ORF	NNP
cord-349417-vn7q8wc4	159	71	)	)	-RRB-
cord-349417-vn7q8wc4	160	1	1b	1b	LS
cord-349417-vn7q8wc4	160	2	-	-	HYPH
cord-349417-vn7q8wc4	160	3	nsp14	nsp14	NNP
cord-349417-vn7q8wc4	160	4	and	and	CC
cord-349417-vn7q8wc4	160	5	ORF	ORF	NNP
cord-349417-vn7q8wc4	160	6	2a	2a	CD
cord-349417-vn7q8wc4	160	7	proteins	protein	NNS
cord-349417-vn7q8wc4	160	8	of	of	IN
cord-349417-vn7q8wc4	160	9	the	the	DT
cord-349417-vn7q8wc4	160	10	coronavirus	coronavirus	NN
cord-349417-vn7q8wc4	160	11	mouse	mouse	NN
cord-349417-vn7q8wc4	160	12	hepatitis	hepatitis	NN
cord-349417-vn7q8wc4	160	13	virus	virus	NN
cord-349417-vn7q8wc4	160	14	are	be	VBP
cord-349417-vn7q8wc4	160	15	attenuating	attenuate	VBG
cord-349417-vn7q8wc4	160	16	in	in	IN
cord-349417-vn7q8wc4	160	17	mice	mouse	NNS