id sid tid token lemma pos cord-304556-1f47gvys 1 1 key key JJ cord-304556-1f47gvys 1 2 : : : cord-304556-1f47gvys 1 3 cord-304556 cord-304556 NNP cord-304556-1f47gvys 1 4 - - HYPH cord-304556-1f47gvys 1 5 1f47gvys 1f47gvys CD cord-304556-1f47gvys 1 6 authors author NNS cord-304556-1f47gvys 1 7 : : : cord-304556-1f47gvys 1 8 Grabiec Grabiec NNP cord-304556-1f47gvys 1 9 , , , cord-304556-1f47gvys 1 10 Aleksander Aleksander NNP cord-304556-1f47gvys 1 11 M. M. NNP cord-304556-1f47gvys 1 12 ; ; : cord-304556-1f47gvys 1 13 Hussell Hussell NNP cord-304556-1f47gvys 1 14 , , , cord-304556-1f47gvys 1 15 Tracy Tracy NNP cord-304556-1f47gvys 1 16 title title NN cord-304556-1f47gvys 1 17 : : : cord-304556-1f47gvys 2 1 The the DT cord-304556-1f47gvys 2 2 role role NN cord-304556-1f47gvys 2 3 of of IN cord-304556-1f47gvys 2 4 airway airway NN cord-304556-1f47gvys 2 5 macrophages macrophage NNS cord-304556-1f47gvys 2 6 in in IN cord-304556-1f47gvys 2 7 apoptotic apoptotic JJ cord-304556-1f47gvys 2 8 cell cell NN cord-304556-1f47gvys 2 9 clearance clearance NN cord-304556-1f47gvys 2 10 following follow VBG cord-304556-1f47gvys 2 11 acute acute JJ cord-304556-1f47gvys 2 12 and and CC cord-304556-1f47gvys 2 13 chronic chronic JJ cord-304556-1f47gvys 2 14 lung lung NN cord-304556-1f47gvys 2 15 inflammation inflammation NN cord-304556-1f47gvys 2 16 date date NN cord-304556-1f47gvys 2 17 : : : cord-304556-1f47gvys 2 18 2016 2016 CD cord-304556-1f47gvys 2 19 - - HYPH cord-304556-1f47gvys 2 20 03 03 CD cord-304556-1f47gvys 2 21 - - HYPH cord-304556-1f47gvys 2 22 08 08 CD cord-304556-1f47gvys 2 23 journal journal NN cord-304556-1f47gvys 2 24 : : : cord-304556-1f47gvys 3 1 Semin Semin NNP cord-304556-1f47gvys 4 1 Immunopathol Immunopathol NNP cord-304556-1f47gvys 4 2 DOI DOI NNP cord-304556-1f47gvys 4 3 : : : cord-304556-1f47gvys 5 1 10.1007 10.1007 CD cord-304556-1f47gvys 5 2 / / SYM cord-304556-1f47gvys 5 3 s00281 s00281 NNP cord-304556-1f47gvys 5 4 - - HYPH cord-304556-1f47gvys 5 5 016 016 CD cord-304556-1f47gvys 5 6 - - HYPH cord-304556-1f47gvys 5 7 0555 0555 CD cord-304556-1f47gvys 5 8 - - SYM cord-304556-1f47gvys 5 9 3 3 CD cord-304556-1f47gvys 5 10 sha sha NNP cord-304556-1f47gvys 5 11 : : : cord-304556-1f47gvys 5 12 d78837afeedbb3c9dfa91a675aa03d34ef5a4387 d78837afeedbb3c9dfa91a675aa03d34ef5a4387 NNP cord-304556-1f47gvys 5 13 doc_id doc_id NNP cord-304556-1f47gvys 5 14 : : : cord-304556-1f47gvys 5 15 304556 304556 CD cord-304556-1f47gvys 5 16 cord_uid cord_uid NNS cord-304556-1f47gvys 5 17 : : : cord-304556-1f47gvys 6 1 1f47gvys 1f47gvys CD cord-304556-1f47gvys 7 1 Acute acute JJ cord-304556-1f47gvys 7 2 and and CC cord-304556-1f47gvys 7 3 chronic chronic JJ cord-304556-1f47gvys 7 4 inflammatory inflammatory JJ cord-304556-1f47gvys 7 5 responses response NNS cord-304556-1f47gvys 7 6 in in IN cord-304556-1f47gvys 7 7 the the DT cord-304556-1f47gvys 7 8 lung lung NN cord-304556-1f47gvys 7 9 are be VBP cord-304556-1f47gvys 7 10 associated associate VBN cord-304556-1f47gvys 7 11 with with IN cord-304556-1f47gvys 7 12 the the DT cord-304556-1f47gvys 7 13 accumulation accumulation NN cord-304556-1f47gvys 7 14 of of IN cord-304556-1f47gvys 7 15 large large JJ cord-304556-1f47gvys 7 16 quantities quantity NNS cord-304556-1f47gvys 7 17 of of IN cord-304556-1f47gvys 7 18 immune immune JJ cord-304556-1f47gvys 7 19 and and CC cord-304556-1f47gvys 7 20 structural structural JJ cord-304556-1f47gvys 7 21 cells cell NNS cord-304556-1f47gvys 7 22 undergoing undergo VBG cord-304556-1f47gvys 7 23 apoptosis apoptosis NN cord-304556-1f47gvys 7 24 , , , cord-304556-1f47gvys 7 25 which which WDT cord-304556-1f47gvys 7 26 need need VBP cord-304556-1f47gvys 7 27 to to TO cord-304556-1f47gvys 7 28 be be VB cord-304556-1f47gvys 7 29 engulfed engulf VBN cord-304556-1f47gvys 7 30 by by IN cord-304556-1f47gvys 7 31 phagocytes phagocyte NNS cord-304556-1f47gvys 7 32 in in IN cord-304556-1f47gvys 7 33 a a DT cord-304556-1f47gvys 7 34 process process NN cord-304556-1f47gvys 7 35 called call VBN cord-304556-1f47gvys 7 36 ‘ ' `` cord-304556-1f47gvys 7 37 efferocytosis efferocytosis NNP cord-304556-1f47gvys 7 38 ’ ' '' cord-304556-1f47gvys 7 39 . . . cord-304556-1f47gvys 8 1 Apoptotic apoptotic JJ cord-304556-1f47gvys 8 2 cell cell NN cord-304556-1f47gvys 8 3 recognition recognition NN cord-304556-1f47gvys 8 4 and and CC cord-304556-1f47gvys 8 5 removal removal NN cord-304556-1f47gvys 8 6 from from IN cord-304556-1f47gvys 8 7 the the DT cord-304556-1f47gvys 8 8 lung lung NN cord-304556-1f47gvys 8 9 is be VBZ cord-304556-1f47gvys 8 10 mediated mediate VBN cord-304556-1f47gvys 8 11 predominantly predominantly RB cord-304556-1f47gvys 8 12 by by IN cord-304556-1f47gvys 8 13 airway airway NN cord-304556-1f47gvys 8 14 macrophages macrophage NNS cord-304556-1f47gvys 8 15 , , , cord-304556-1f47gvys 8 16 though though IN cord-304556-1f47gvys 8 17 immature immature JJ cord-304556-1f47gvys 8 18 dendritic dendritic JJ cord-304556-1f47gvys 8 19 cells cell NNS cord-304556-1f47gvys 8 20 and and CC cord-304556-1f47gvys 8 21 non non JJ cord-304556-1f47gvys 8 22 - - JJ cord-304556-1f47gvys 8 23 professional professional JJ cord-304556-1f47gvys 8 24 phagocytes phagocyte NNS cord-304556-1f47gvys 8 25 , , , cord-304556-1f47gvys 8 26 such such JJ cord-304556-1f47gvys 8 27 as as IN cord-304556-1f47gvys 8 28 epithelial epithelial JJ cord-304556-1f47gvys 8 29 cells cell NNS cord-304556-1f47gvys 8 30 and and CC cord-304556-1f47gvys 8 31 mesenchymal mesenchymal JJ cord-304556-1f47gvys 8 32 cells cell NNS cord-304556-1f47gvys 8 33 , , , cord-304556-1f47gvys 8 34 can can MD cord-304556-1f47gvys 8 35 also also RB cord-304556-1f47gvys 8 36 display display VB cord-304556-1f47gvys 8 37 this this DT cord-304556-1f47gvys 8 38 function function NN cord-304556-1f47gvys 8 39 . . . cord-304556-1f47gvys 9 1 Efficient efficient JJ cord-304556-1f47gvys 9 2 clearance clearance NN cord-304556-1f47gvys 9 3 of of IN cord-304556-1f47gvys 9 4 apoptotic apoptotic JJ cord-304556-1f47gvys 9 5 cells cell NNS cord-304556-1f47gvys 9 6 from from IN cord-304556-1f47gvys 9 7 the the DT cord-304556-1f47gvys 9 8 airways airways NNP cord-304556-1f47gvys 9 9 is be VBZ cord-304556-1f47gvys 9 10 essential essential JJ cord-304556-1f47gvys 9 11 for for IN cord-304556-1f47gvys 9 12 successful successful JJ cord-304556-1f47gvys 9 13 resolution resolution NN cord-304556-1f47gvys 9 14 of of IN cord-304556-1f47gvys 9 15 inflammation inflammation NN cord-304556-1f47gvys 9 16 and and CC cord-304556-1f47gvys 9 17 the the DT cord-304556-1f47gvys 9 18 return return NN cord-304556-1f47gvys 9 19 to to IN cord-304556-1f47gvys 9 20 lung lung NN cord-304556-1f47gvys 9 21 homeostasis homeostasis NN cord-304556-1f47gvys 9 22 . . . cord-304556-1f47gvys 10 1 Disruption disruption NN cord-304556-1f47gvys 10 2 of of IN cord-304556-1f47gvys 10 3 this this DT cord-304556-1f47gvys 10 4 process process NN cord-304556-1f47gvys 10 5 leads lead VBZ cord-304556-1f47gvys 10 6 to to IN cord-304556-1f47gvys 10 7 secondary secondary JJ cord-304556-1f47gvys 10 8 necrosis necrosis NN cord-304556-1f47gvys 10 9 of of IN cord-304556-1f47gvys 10 10 accumulating accumulate VBG cord-304556-1f47gvys 10 11 apoptotic apoptotic JJ cord-304556-1f47gvys 10 12 cells cell NNS cord-304556-1f47gvys 10 13 , , , cord-304556-1f47gvys 10 14 release release NN cord-304556-1f47gvys 10 15 of of IN cord-304556-1f47gvys 10 16 necrotic necrotic JJ cord-304556-1f47gvys 10 17 cell cell NN cord-304556-1f47gvys 10 18 debris debris NN cord-304556-1f47gvys 10 19 and and CC cord-304556-1f47gvys 10 20 subsequent subsequent JJ cord-304556-1f47gvys 10 21 uncontrolled uncontrolled JJ cord-304556-1f47gvys 10 22 inflammatory inflammatory JJ cord-304556-1f47gvys 10 23 activation activation NN cord-304556-1f47gvys 10 24 of of IN cord-304556-1f47gvys 10 25 the the DT cord-304556-1f47gvys 10 26 innate innate JJ cord-304556-1f47gvys 10 27 immune immune JJ cord-304556-1f47gvys 10 28 system system NN cord-304556-1f47gvys 10 29 by by IN cord-304556-1f47gvys 10 30 the the DT cord-304556-1f47gvys 10 31 released release VBN cord-304556-1f47gvys 10 32 ‘ ' `` cord-304556-1f47gvys 10 33 damage damage NN cord-304556-1f47gvys 10 34 associated associate VBD cord-304556-1f47gvys 10 35 molecular molecular JJ cord-304556-1f47gvys 10 36 patterns pattern NNS cord-304556-1f47gvys 10 37 ’ ' '' cord-304556-1f47gvys 10 38 ( ( -LRB- cord-304556-1f47gvys 10 39 DAMPS DAMPS NNP cord-304556-1f47gvys 10 40 ) ) -RRB- cord-304556-1f47gvys 10 41 . . . cord-304556-1f47gvys 11 1 To to TO cord-304556-1f47gvys 11 2 control control VB cord-304556-1f47gvys 11 3 the the DT cord-304556-1f47gvys 11 4 duration duration NN cord-304556-1f47gvys 11 5 of of IN cord-304556-1f47gvys 11 6 the the DT cord-304556-1f47gvys 11 7 immune immune JJ cord-304556-1f47gvys 11 8 response response NN cord-304556-1f47gvys 11 9 and and CC cord-304556-1f47gvys 11 10 prevent prevent VB cord-304556-1f47gvys 11 11 autoimmune autoimmune JJ cord-304556-1f47gvys 11 12 reactions reaction NNS cord-304556-1f47gvys 11 13 , , , cord-304556-1f47gvys 11 14 anti anti JJ cord-304556-1f47gvys 11 15 - - JJ cord-304556-1f47gvys 11 16 inflammatory inflammatory JJ cord-304556-1f47gvys 11 17 signalling signalling NN cord-304556-1f47gvys 11 18 cascades cascade NNS cord-304556-1f47gvys 11 19 are be VBP cord-304556-1f47gvys 11 20 initiated initiate VBN cord-304556-1f47gvys 11 21 in in IN cord-304556-1f47gvys 11 22 the the DT cord-304556-1f47gvys 11 23 phagocyte phagocyte NNP cord-304556-1f47gvys 11 24 upon upon IN cord-304556-1f47gvys 11 25 apoptotic apoptotic JJ cord-304556-1f47gvys 11 26 cell cell NN cord-304556-1f47gvys 11 27 uptake uptake NN cord-304556-1f47gvys 11 28 , , , cord-304556-1f47gvys 11 29 mediated mediate VBN cord-304556-1f47gvys 11 30 by by IN cord-304556-1f47gvys 11 31 a a DT cord-304556-1f47gvys 11 32 range range NN cord-304556-1f47gvys 11 33 of of IN cord-304556-1f47gvys 11 34 receptors receptor NNS cord-304556-1f47gvys 11 35 that that WDT cord-304556-1f47gvys 11 36 recognise recognise VBP cord-304556-1f47gvys 11 37 specific specific JJ cord-304556-1f47gvys 11 38 phospholipids phospholipid NNS cord-304556-1f47gvys 11 39 or or CC cord-304556-1f47gvys 11 40 proteins protein NNS cord-304556-1f47gvys 11 41 externalised externalise VBN cord-304556-1f47gvys 11 42 on on IN cord-304556-1f47gvys 11 43 , , , cord-304556-1f47gvys 11 44 or or CC cord-304556-1f47gvys 11 45 secreted secrete VBN cord-304556-1f47gvys 11 46 by by IN cord-304556-1f47gvys 11 47 , , , cord-304556-1f47gvys 11 48 the the DT cord-304556-1f47gvys 11 49 apoptotic apoptotic JJ cord-304556-1f47gvys 11 50 cell cell NN cord-304556-1f47gvys 11 51 . . . cord-304556-1f47gvys 12 1 However however RB cord-304556-1f47gvys 12 2 , , , cord-304556-1f47gvys 12 3 prolonged prolonged JJ cord-304556-1f47gvys 12 4 activation activation NN cord-304556-1f47gvys 12 5 of of IN cord-304556-1f47gvys 12 6 apoptotic apoptotic JJ cord-304556-1f47gvys 12 7 cell cell NN cord-304556-1f47gvys 12 8 recognition recognition NN cord-304556-1f47gvys 12 9 receptors receptor NNS cord-304556-1f47gvys 12 10 , , , cord-304556-1f47gvys 12 11 such such JJ cord-304556-1f47gvys 12 12 as as IN cord-304556-1f47gvys 12 13 the the DT cord-304556-1f47gvys 12 14 family family NN cord-304556-1f47gvys 12 15 of of IN cord-304556-1f47gvys 12 16 receptor receptor NN cord-304556-1f47gvys 12 17 tyrosine tyrosine NN cord-304556-1f47gvys 12 18 kinases kinase NNS cord-304556-1f47gvys 12 19 Tyro3 tyro3 RB cord-304556-1f47gvys 12 20 , , , cord-304556-1f47gvys 12 21 Axl Axl NNP cord-304556-1f47gvys 12 22 and and CC cord-304556-1f47gvys 12 23 MerTK MerTK NNP cord-304556-1f47gvys 12 24 ( ( -LRB- cord-304556-1f47gvys 12 25 TAM TAM NNP cord-304556-1f47gvys 12 26 ) ) -RRB- cord-304556-1f47gvys 12 27 , , , cord-304556-1f47gvys 12 28 may may MD cord-304556-1f47gvys 12 29 delay delay VB cord-304556-1f47gvys 12 30 or or CC cord-304556-1f47gvys 12 31 prevent prevent VB cord-304556-1f47gvys 12 32 inflammatory inflammatory JJ cord-304556-1f47gvys 12 33 responses response NNS cord-304556-1f47gvys 12 34 to to IN cord-304556-1f47gvys 12 35 subsequent subsequent JJ cord-304556-1f47gvys 12 36 infections infection NNS cord-304556-1f47gvys 12 37 . . . cord-304556-1f47gvys 13 1 In in IN cord-304556-1f47gvys 13 2 this this DT cord-304556-1f47gvys 13 3 review review NN cord-304556-1f47gvys 13 4 , , , cord-304556-1f47gvys 13 5 we -PRON- PRP cord-304556-1f47gvys 13 6 will will MD cord-304556-1f47gvys 13 7 discuss discuss VB cord-304556-1f47gvys 13 8 recent recent JJ cord-304556-1f47gvys 13 9 advances advance NNS cord-304556-1f47gvys 13 10 in in IN cord-304556-1f47gvys 13 11 our -PRON- PRP$ cord-304556-1f47gvys 13 12 understanding understanding NN cord-304556-1f47gvys 13 13 of of IN cord-304556-1f47gvys 13 14 the the DT cord-304556-1f47gvys 13 15 mechanism mechanism NN cord-304556-1f47gvys 13 16 controlling control VBG cord-304556-1f47gvys 13 17 apoptotic apoptotic JJ cord-304556-1f47gvys 13 18 cell cell NN cord-304556-1f47gvys 13 19 recognition recognition NN cord-304556-1f47gvys 13 20 and and CC cord-304556-1f47gvys 13 21 removal removal NN cord-304556-1f47gvys 13 22 from from IN cord-304556-1f47gvys 13 23 the the DT cord-304556-1f47gvys 13 24 lung lung NN cord-304556-1f47gvys 13 25 in in IN cord-304556-1f47gvys 13 26 homeostasis homeostasis NN cord-304556-1f47gvys 13 27 and and CC cord-304556-1f47gvys 13 28 during during IN cord-304556-1f47gvys 13 29 inflammation inflammation NN cord-304556-1f47gvys 13 30 , , , cord-304556-1f47gvys 13 31 the the DT cord-304556-1f47gvys 13 32 contribution contribution NN cord-304556-1f47gvys 13 33 of of IN cord-304556-1f47gvys 13 34 defective defective JJ cord-304556-1f47gvys 13 35 efferocytosis efferocytosis NN cord-304556-1f47gvys 13 36 to to TO cord-304556-1f47gvys 13 37 chronic chronic VB cord-304556-1f47gvys 13 38 inflammatory inflammatory JJ cord-304556-1f47gvys 13 39 lung lung NN cord-304556-1f47gvys 13 40 diseases disease NNS cord-304556-1f47gvys 13 41 , , , cord-304556-1f47gvys 13 42 such such JJ cord-304556-1f47gvys 13 43 as as IN cord-304556-1f47gvys 13 44 chronic chronic JJ cord-304556-1f47gvys 13 45 obstructive obstructive JJ cord-304556-1f47gvys 13 46 pulmonary pulmonary JJ cord-304556-1f47gvys 13 47 disease disease NN cord-304556-1f47gvys 13 48 , , , cord-304556-1f47gvys 13 49 asthma asthma NN cord-304556-1f47gvys 13 50 and and CC cord-304556-1f47gvys 13 51 cystic cystic JJ cord-304556-1f47gvys 13 52 fibrosis fibrosis NN cord-304556-1f47gvys 13 53 , , , cord-304556-1f47gvys 13 54 and and CC cord-304556-1f47gvys 13 55 implications implication NNS cord-304556-1f47gvys 13 56 of of IN cord-304556-1f47gvys 13 57 the the DT cord-304556-1f47gvys 13 58 signals signal NNS cord-304556-1f47gvys 13 59 triggered trigger VBN cord-304556-1f47gvys 13 60 by by IN cord-304556-1f47gvys 13 61 apoptotic apoptotic JJ cord-304556-1f47gvys 13 62 cells cell NNS cord-304556-1f47gvys 13 63 in in IN cord-304556-1f47gvys 13 64 the the DT cord-304556-1f47gvys 13 65 susceptibility susceptibility NN cord-304556-1f47gvys 13 66 to to IN cord-304556-1f47gvys 13 67 pulmonary pulmonary JJ cord-304556-1f47gvys 13 68 microbial microbial JJ cord-304556-1f47gvys 13 69 infections infection NNS cord-304556-1f47gvys 13 70 . . . cord-304556-1f47gvys 14 1 understanding understanding NN cord-304556-1f47gvys 14 2 of of IN cord-304556-1f47gvys 14 3 the the DT cord-304556-1f47gvys 14 4 mechanism mechanism NN cord-304556-1f47gvys 14 5 controlling control VBG cord-304556-1f47gvys 14 6 apoptotic apoptotic JJ cord-304556-1f47gvys 14 7 cell cell NN cord-304556-1f47gvys 14 8 recognition recognition NN cord-304556-1f47gvys 14 9 and and CC cord-304556-1f47gvys 14 10 removal removal NN cord-304556-1f47gvys 14 11 from from IN cord-304556-1f47gvys 14 12 the the DT cord-304556-1f47gvys 14 13 lung lung NN cord-304556-1f47gvys 14 14 in in IN cord-304556-1f47gvys 14 15 homeostasis homeostasis NN cord-304556-1f47gvys 14 16 and and CC cord-304556-1f47gvys 14 17 during during IN cord-304556-1f47gvys 14 18 inflammation inflammation NN cord-304556-1f47gvys 14 19 , , , cord-304556-1f47gvys 14 20 the the DT cord-304556-1f47gvys 14 21 contribution contribution NN cord-304556-1f47gvys 14 22 of of IN cord-304556-1f47gvys 14 23 defective defective JJ cord-304556-1f47gvys 14 24 efferocytosis efferocytosis NN cord-304556-1f47gvys 14 25 to to TO cord-304556-1f47gvys 14 26 chronic chronic VB cord-304556-1f47gvys 14 27 inflammatory inflammatory JJ cord-304556-1f47gvys 14 28 lung lung NN cord-304556-1f47gvys 14 29 diseases disease NNS cord-304556-1f47gvys 14 30 , , , cord-304556-1f47gvys 14 31 such such JJ cord-304556-1f47gvys 14 32 as as IN cord-304556-1f47gvys 14 33 chronic chronic JJ cord-304556-1f47gvys 14 34 obstructive obstructive JJ cord-304556-1f47gvys 14 35 pulmonary pulmonary JJ cord-304556-1f47gvys 14 36 disease disease NN cord-304556-1f47gvys 14 37 , , , cord-304556-1f47gvys 14 38 asthma asthma NN cord-304556-1f47gvys 14 39 and and CC cord-304556-1f47gvys 14 40 cystic cystic JJ cord-304556-1f47gvys 14 41 fibrosis fibrosis NN cord-304556-1f47gvys 14 42 , , , cord-304556-1f47gvys 14 43 and and CC cord-304556-1f47gvys 14 44 implications implication NNS cord-304556-1f47gvys 14 45 of of IN cord-304556-1f47gvys 14 46 the the DT cord-304556-1f47gvys 14 47 signals signal NNS cord-304556-1f47gvys 14 48 triggered trigger VBN cord-304556-1f47gvys 14 49 by by IN cord-304556-1f47gvys 14 50 apoptotic apoptotic JJ cord-304556-1f47gvys 14 51 cells cell NNS cord-304556-1f47gvys 14 52 in in IN cord-304556-1f47gvys 14 53 the the DT cord-304556-1f47gvys 14 54 susceptibility susceptibility NN cord-304556-1f47gvys 14 55 to to IN cord-304556-1f47gvys 14 56 pulmonary pulmonary JJ cord-304556-1f47gvys 14 57 microbial microbial JJ cord-304556-1f47gvys 14 58 infections infection NNS cord-304556-1f47gvys 14 59 . . . cord-304556-1f47gvys 15 1 Keywords Keywords NNP cord-304556-1f47gvys 15 2 Efferocytosis Efferocytosis NNP cord-304556-1f47gvys 15 3 . . . cord-304556-1f47gvys 16 1 Phosphatidylserine Phosphatidylserine NNP cord-304556-1f47gvys 16 2 . . . cord-304556-1f47gvys 17 1 Apoptotic apoptotic JJ cord-304556-1f47gvys 17 2 cell cell NN cord-304556-1f47gvys 17 3 clearance clearance NN cord-304556-1f47gvys 17 4 . . . cord-304556-1f47gvys 18 1 Lung lung NN cord-304556-1f47gvys 18 2 . . . cord-304556-1f47gvys 19 1 Airway airway NN cord-304556-1f47gvys 19 2 macrophage macrophage NN cord-304556-1f47gvys 19 3 . . . cord-304556-1f47gvys 20 1 Inflammation inflammation NN cord-304556-1f47gvys 20 2 Cellular cellular JJ cord-304556-1f47gvys 20 3 turnover turnover NN cord-304556-1f47gvys 20 4 occurs occur VBZ cord-304556-1f47gvys 20 5 as as IN cord-304556-1f47gvys 20 6 part part NN cord-304556-1f47gvys 20 7 of of IN cord-304556-1f47gvys 20 8 the the DT cord-304556-1f47gvys 20 9 normal normal JJ cord-304556-1f47gvys 20 10 homeostatic homeostatic JJ cord-304556-1f47gvys 20 11 process process NN cord-304556-1f47gvys 20 12 and and CC cord-304556-1f47gvys 20 13 is be VBZ cord-304556-1f47gvys 20 14 vital vital JJ cord-304556-1f47gvys 20 15 for for IN cord-304556-1f47gvys 20 16 the the DT cord-304556-1f47gvys 20 17 contraction contraction NN cord-304556-1f47gvys 20 18 of of IN cord-304556-1f47gvys 20 19 cells cell NNS cord-304556-1f47gvys 20 20 recruited recruit VBN cord-304556-1f47gvys 20 21 during during IN cord-304556-1f47gvys 20 22 an an DT cord-304556-1f47gvys 20 23 inflammatory inflammatory JJ cord-304556-1f47gvys 20 24 response response NN cord-304556-1f47gvys 20 25 [ [ -LRB- cord-304556-1f47gvys 20 26 1 1 CD cord-304556-1f47gvys 20 27 ] ] -RRB- cord-304556-1f47gvys 20 28 . . . cord-304556-1f47gvys 21 1 As as IN cord-304556-1f47gvys 21 2 with with IN cord-304556-1f47gvys 21 3 most most JJS cord-304556-1f47gvys 21 4 biological biological JJ cord-304556-1f47gvys 21 5 processes process NNS cord-304556-1f47gvys 21 6 , , , cord-304556-1f47gvys 21 7 it -PRON- PRP cord-304556-1f47gvys 21 8 is be VBZ cord-304556-1f47gvys 21 9 becoming become VBG cord-304556-1f47gvys 21 10 apparent apparent JJ cord-304556-1f47gvys 21 11 that that IN cord-304556-1f47gvys 21 12 turnover turnover NN cord-304556-1f47gvys 21 13 of of IN cord-304556-1f47gvys 21 14 cells cell NNS cord-304556-1f47gvys 21 15 is be VBZ cord-304556-1f47gvys 21 16 regulated regulate VBN cord-304556-1f47gvys 21 17 in in IN cord-304556-1f47gvys 21 18 a a DT cord-304556-1f47gvys 21 19 tissue tissue NN cord-304556-1f47gvys 21 20 - - HYPH cord-304556-1f47gvys 21 21 specific specific JJ cord-304556-1f47gvys 21 22 manner manner NN cord-304556-1f47gvys 21 23 and and CC cord-304556-1f47gvys 21 24 this this DT cord-304556-1f47gvys 21 25 specificity specificity NN cord-304556-1f47gvys 21 26 is be VBZ cord-304556-1f47gvys 21 27 primarily primarily RB cord-304556-1f47gvys 21 28 driven drive VBN cord-304556-1f47gvys 21 29 by by IN cord-304556-1f47gvys 21 30 locally locally RB cord-304556-1f47gvys 21 31 produced produce VBN cord-304556-1f47gvys 21 32 factors factor NNS cord-304556-1f47gvys 21 33 . . . cord-304556-1f47gvys 22 1 For for IN cord-304556-1f47gvys 22 2 example example NN cord-304556-1f47gvys 22 3 , , , cord-304556-1f47gvys 22 4 the the DT cord-304556-1f47gvys 22 5 unique unique JJ cord-304556-1f47gvys 22 6 microenvironment microenvironment NN cord-304556-1f47gvys 22 7 of of IN cord-304556-1f47gvys 22 8 the the DT cord-304556-1f47gvys 22 9 airspaces airspace NNS cord-304556-1f47gvys 22 10 drives drive VBZ cord-304556-1f47gvys 22 11 a a DT cord-304556-1f47gvys 22 12 distinct distinct JJ cord-304556-1f47gvys 22 13 expression expression NN cord-304556-1f47gvys 22 14 pattern pattern NN cord-304556-1f47gvys 22 15 of of IN cord-304556-1f47gvys 22 16 apoptotic apoptotic JJ cord-304556-1f47gvys 22 17 cell cell NN cord-304556-1f47gvys 22 18 recognition recognition NN cord-304556-1f47gvys 22 19 receptors receptor NNS cord-304556-1f47gvys 22 20 on on IN cord-304556-1f47gvys 22 21 airway airway NN cord-304556-1f47gvys 22 22 macrophages macrophage NNS cord-304556-1f47gvys 22 23 compared compare VBN cord-304556-1f47gvys 22 24 to to IN cord-304556-1f47gvys 22 25 tissue tissue NN cord-304556-1f47gvys 22 26 - - HYPH cord-304556-1f47gvys 22 27 resident resident NN cord-304556-1f47gvys 22 28 macrophages macrophage NNS cord-304556-1f47gvys 22 29 from from IN cord-304556-1f47gvys 22 30 other other JJ cord-304556-1f47gvys 22 31 anatomical anatomical JJ cord-304556-1f47gvys 22 32 locations location NNS cord-304556-1f47gvys 22 33 [ [ -LRB- cord-304556-1f47gvys 22 34 2 2 CD cord-304556-1f47gvys 22 35 ] ] -RRB- cord-304556-1f47gvys 22 36 . . . cord-304556-1f47gvys 23 1 In in IN cord-304556-1f47gvys 23 2 the the DT cord-304556-1f47gvys 23 3 airways airway NNS cord-304556-1f47gvys 23 4 , , , cord-304556-1f47gvys 23 5 cell cell NN cord-304556-1f47gvys 23 6 turnover turnover NN cord-304556-1f47gvys 23 7 is be VBZ cord-304556-1f47gvys 23 8 primarily primarily RB cord-304556-1f47gvys 23 9 mediated mediate VBN cord-304556-1f47gvys 23 10 by by IN cord-304556-1f47gvys 23 11 induction induction NN cord-304556-1f47gvys 23 12 of of IN cord-304556-1f47gvys 23 13 apoptosis apoptosis NN cord-304556-1f47gvys 23 14 followed follow VBN cord-304556-1f47gvys 23 15 by by IN cord-304556-1f47gvys 23 16 engulfment engulfment NN cord-304556-1f47gvys 23 17 of of IN cord-304556-1f47gvys 23 18 apoptotic apoptotic JJ cord-304556-1f47gvys 23 19 cells cell NNS cord-304556-1f47gvys 23 20 by by IN cord-304556-1f47gvys 23 21 phagocytes phagocyte NNS cord-304556-1f47gvys 23 22 , , , cord-304556-1f47gvys 23 23 called call VBD cord-304556-1f47gvys 23 24 ' ' `` cord-304556-1f47gvys 23 25 efferocytosis efferocytosis NN cord-304556-1f47gvys 23 26 ' ' '' cord-304556-1f47gvys 23 27 . . . cord-304556-1f47gvys 24 1 The the DT cord-304556-1f47gvys 24 2 term term NN cord-304556-1f47gvys 24 3 ' ' `` cord-304556-1f47gvys 24 4 efferocytosis efferocytosis NN cord-304556-1f47gvys 24 5 ' ' '' cord-304556-1f47gvys 24 6 was be VBD cord-304556-1f47gvys 24 7 coined coin VBN cord-304556-1f47gvys 24 8 to to IN cord-304556-1f47gvys 24 9 separate separate JJ cord-304556-1f47gvys 24 10 engulfment engulfment NN cord-304556-1f47gvys 24 11 of of IN cord-304556-1f47gvys 24 12 apoptotic apoptotic JJ cord-304556-1f47gvys 24 13 cells cell NNS cord-304556-1f47gvys 24 14 from from IN cord-304556-1f47gvys 24 15 other other JJ cord-304556-1f47gvys 24 16 forms form NNS cord-304556-1f47gvys 24 17 of of IN cord-304556-1f47gvys 24 18 phagocytosis phagocytosis NN cord-304556-1f47gvys 24 19 and and CC cord-304556-1f47gvys 24 20 derived derive VBN cord-304556-1f47gvys 24 21 from from IN cord-304556-1f47gvys 24 22 the the DT cord-304556-1f47gvys 24 23 Latin latin JJ cord-304556-1f47gvys 24 24 word word NN cord-304556-1f47gvys 24 25 ' ' `` cord-304556-1f47gvys 24 26 effere effere NN cord-304556-1f47gvys 24 27 ' ' '' cord-304556-1f47gvys 24 28 that that WDT cord-304556-1f47gvys 24 29 translates translate VBZ cord-304556-1f47gvys 24 30 as as IN cord-304556-1f47gvys 24 31 ' ' `` cord-304556-1f47gvys 24 32 take take VB cord-304556-1f47gvys 24 33 to to IN cord-304556-1f47gvys 24 34 the the DT cord-304556-1f47gvys 24 35 grave grave NN cord-304556-1f47gvys 24 36 ' ' '' cord-304556-1f47gvys 24 37 . . . cord-304556-1f47gvys 25 1 While while IN cord-304556-1f47gvys 25 2 phagocytosis phagocytosis NN cord-304556-1f47gvys 25 3 of of IN cord-304556-1f47gvys 25 4 pathogens pathogen NNS cord-304556-1f47gvys 25 5 requires require VBZ cord-304556-1f47gvys 25 6 initiation initiation NN cord-304556-1f47gvys 25 7 of of IN cord-304556-1f47gvys 25 8 an an DT cord-304556-1f47gvys 25 9 inflammatory inflammatory JJ cord-304556-1f47gvys 25 10 response response NN cord-304556-1f47gvys 25 11 , , , cord-304556-1f47gvys 25 12 removal removal NN cord-304556-1f47gvys 25 13 of of IN cord-304556-1f47gvys 25 14 self self NN cord-304556-1f47gvys 25 15 - - HYPH cord-304556-1f47gvys 25 16 cells cell NNS cord-304556-1f47gvys 25 17 that that WDT cord-304556-1f47gvys 25 18 undergo undergo VBP cord-304556-1f47gvys 25 19 apoptosis apoptosis NN cord-304556-1f47gvys 25 20 is be VBZ cord-304556-1f47gvys 25 21 a a DT cord-304556-1f47gvys 25 22 tolerogenic tolerogenic JJ cord-304556-1f47gvys 25 23 process process NN cord-304556-1f47gvys 25 24 that that WDT cord-304556-1f47gvys 25 25 prevents prevent VBZ cord-304556-1f47gvys 25 26 excessive excessive JJ cord-304556-1f47gvys 25 27 inflammation inflammation NN cord-304556-1f47gvys 25 28 and/or and/or CC cord-304556-1f47gvys 25 29 autoimmunity autoimmunity NN cord-304556-1f47gvys 25 30 caused cause VBN cord-304556-1f47gvys 25 31 by by IN cord-304556-1f47gvys 25 32 the the DT cord-304556-1f47gvys 25 33 release release NN cord-304556-1f47gvys 25 34 of of IN cord-304556-1f47gvys 25 35 ' ' `` cord-304556-1f47gvys 25 36 damage damage NN cord-304556-1f47gvys 25 37 associated associate VBD cord-304556-1f47gvys 25 38 molecular molecular JJ cord-304556-1f47gvys 25 39 patterns pattern NNS cord-304556-1f47gvys 25 40 ' ' '' cord-304556-1f47gvys 25 41 ( ( -LRB- cord-304556-1f47gvys 25 42 DAMPS damps NN cord-304556-1f47gvys 25 43 ) ) -RRB- cord-304556-1f47gvys 25 44 from from IN cord-304556-1f47gvys 25 45 apoptotic apoptotic JJ cord-304556-1f47gvys 25 46 cells cell NNS cord-304556-1f47gvys 25 47 that that WDT cord-304556-1f47gvys 25 48 are be VBP cord-304556-1f47gvys 25 49 not not RB cord-304556-1f47gvys 25 50 cleared clear VBN cord-304556-1f47gvys 25 51 in in IN cord-304556-1f47gvys 25 52 a a DT cord-304556-1f47gvys 25 53 timely timely JJ cord-304556-1f47gvys 25 54 manner manner NN cord-304556-1f47gvys 25 55 and and CC cord-304556-1f47gvys 25 56 undergo undergo VB cord-304556-1f47gvys 25 57 secondary secondary JJ cord-304556-1f47gvys 25 58 necrosis necrosis NN cord-304556-1f47gvys 25 59 . . . cord-304556-1f47gvys 26 1 To to TO cord-304556-1f47gvys 26 2 achieve achieve VB cord-304556-1f47gvys 26 3 this this DT cord-304556-1f47gvys 26 4 distinction distinction NN cord-304556-1f47gvys 26 5 , , , cord-304556-1f47gvys 26 6 macrophages macrophage NNS cord-304556-1f47gvys 26 7 and and CC cord-304556-1f47gvys 26 8 other other JJ cord-304556-1f47gvys 26 9 phagocytes phagocyte NNS cord-304556-1f47gvys 26 10 utilise utilise VBP cord-304556-1f47gvys 26 11 different different JJ cord-304556-1f47gvys 26 12 sets set NNS cord-304556-1f47gvys 26 13 of of IN cord-304556-1f47gvys 26 14 receptors receptor NNS cord-304556-1f47gvys 26 15 to to TO cord-304556-1f47gvys 26 16 recognise recognise VB cord-304556-1f47gvys 26 17 microbial microbial JJ cord-304556-1f47gvys 26 18 particles particle NNS cord-304556-1f47gvys 26 19 and and CC cord-304556-1f47gvys 26 20 cells cell NNS cord-304556-1f47gvys 26 21 undergoing undergo VBG cord-304556-1f47gvys 26 22 apoptosis apoptosis NN cord-304556-1f47gvys 26 23 , , , cord-304556-1f47gvys 26 24 activation activation NN cord-304556-1f47gvys 26 25 of of IN cord-304556-1f47gvys 26 26 which which WDT cord-304556-1f47gvys 26 27 subsequently subsequently RB cord-304556-1f47gvys 26 28 leads lead VBZ cord-304556-1f47gvys 26 29 to to IN cord-304556-1f47gvys 26 30 distinct distinct JJ cord-304556-1f47gvys 26 31 cell cell NN cord-304556-1f47gvys 26 32 activation activation NN cord-304556-1f47gvys 26 33 programmes programme NNS cord-304556-1f47gvys 26 34 . . . cord-304556-1f47gvys 27 1 Whereas whereas IN cord-304556-1f47gvys 27 2 phagocytosis phagocytosis NN cord-304556-1f47gvys 27 3 of of IN cord-304556-1f47gvys 27 4 pathogens pathogen NNS cord-304556-1f47gvys 27 5 triggers trigger VBZ cord-304556-1f47gvys 27 6 conserved conserve VBN cord-304556-1f47gvys 27 7 pro pro JJ cord-304556-1f47gvys 27 8 - - JJ cord-304556-1f47gvys 27 9 inflammatory inflammatory JJ cord-304556-1f47gvys 27 10 signalling signal VBG cord-304556-1f47gvys 27 11 pathways pathway NNS cord-304556-1f47gvys 27 12 , , , cord-304556-1f47gvys 27 13 engulfment engulfment NN cord-304556-1f47gvys 27 14 of of IN cord-304556-1f47gvys 27 15 apoptotic apoptotic JJ cord-304556-1f47gvys 27 16 cells cell NNS cord-304556-1f47gvys 27 17 by by IN cord-304556-1f47gvys 27 18 phagocytes phagocyte NNS cord-304556-1f47gvys 27 19 may may MD cord-304556-1f47gvys 27 20 promote promote VB cord-304556-1f47gvys 27 21 the the DT cord-304556-1f47gvys 27 22 wound wound NN cord-304556-1f47gvys 27 23 repair repair NN cord-304556-1f47gvys 27 24 process process NN cord-304556-1f47gvys 27 25 , , , cord-304556-1f47gvys 27 26 the the DT cord-304556-1f47gvys 27 27 production production NN cord-304556-1f47gvys 27 28 of of IN cord-304556-1f47gvys 27 29 factors factor NNS cord-304556-1f47gvys 27 30 to to TO cord-304556-1f47gvys 27 31 curtail curtail VB cord-304556-1f47gvys 27 32 inflammation inflammation NN cord-304556-1f47gvys 27 33 or or CC cord-304556-1f47gvys 27 34 the the DT cord-304556-1f47gvys 27 35 secretion secretion NN cord-304556-1f47gvys 27 36 of of IN cord-304556-1f47gvys 27 37 growth growth NN cord-304556-1f47gvys 27 38 factors factor NNS cord-304556-1f47gvys 27 39 to to TO cord-304556-1f47gvys 27 40 shape shape VB cord-304556-1f47gvys 27 41 a a DT cord-304556-1f47gvys 27 42 developing develop VBG cord-304556-1f47gvys 27 43 tissue tissue NN cord-304556-1f47gvys 27 44 . . . cord-304556-1f47gvys 28 1 Efferocytosis efferocytosis NN cord-304556-1f47gvys 28 2 therefore therefore RB cord-304556-1f47gvys 28 3 leads lead VBZ cord-304556-1f47gvys 28 4 to to IN cord-304556-1f47gvys 28 5 different different JJ cord-304556-1f47gvys 28 6 consequences consequence NNS cord-304556-1f47gvys 28 7 and and CC cord-304556-1f47gvys 28 8 is be VBZ cord-304556-1f47gvys 28 9 a a DT cord-304556-1f47gvys 28 10 burgeoning burgeon VBG cord-304556-1f47gvys 28 11 focus focus NN cord-304556-1f47gvys 28 12 of of IN cord-304556-1f47gvys 28 13 research research NN cord-304556-1f47gvys 28 14 , , , cord-304556-1f47gvys 28 15 driven drive VBN cord-304556-1f47gvys 28 16 by by IN cord-304556-1f47gvys 28 17 the the DT cord-304556-1f47gvys 28 18 discovery discovery NN cord-304556-1f47gvys 28 19 of of IN cord-304556-1f47gvys 28 20 ever ever RB cord-304556-1f47gvys 28 21 more more RBR cord-304556-1f47gvys 28 22 apoptotic apoptotic JJ cord-304556-1f47gvys 28 23 cell cell NN cord-304556-1f47gvys 28 24 recognition recognition NN cord-304556-1f47gvys 28 25 receptors receptor NNS cord-304556-1f47gvys 28 26 and and CC cord-304556-1f47gvys 28 27 , , , cord-304556-1f47gvys 28 28 importantly importantly RB cord-304556-1f47gvys 28 29 , , , cord-304556-1f47gvys 28 30 pathogens pathogen NNS cord-304556-1f47gvys 28 31 that that WDT cord-304556-1f47gvys 28 32 use use VBP cord-304556-1f47gvys 28 33 the the DT cord-304556-1f47gvys 28 34 apoptotic apoptotic JJ cord-304556-1f47gvys 28 35 cell cell NN cord-304556-1f47gvys 28 36 clearance clearance NN cord-304556-1f47gvys 28 37 process process NN cord-304556-1f47gvys 28 38 to to TO cord-304556-1f47gvys 28 39 facilitate facilitate VB cord-304556-1f47gvys 28 40 their -PRON- PRP$ cord-304556-1f47gvys 28 41 entry entry NN cord-304556-1f47gvys 28 42 into into IN cord-304556-1f47gvys 28 43 host host NN cord-304556-1f47gvys 28 44 cells cell NNS cord-304556-1f47gvys 28 45 and/or and/or CC cord-304556-1f47gvys 28 46 subvert subvert VB cord-304556-1f47gvys 28 47 anti anti JJ cord-304556-1f47gvys 28 48 - - JJ cord-304556-1f47gvys 28 49 pathogen pathogen JJ cord-304556-1f47gvys 28 50 immunity immunity NN cord-304556-1f47gvys 28 51 . . . cord-304556-1f47gvys 29 1 The the DT cord-304556-1f47gvys 29 2 distinction distinction NN cord-304556-1f47gvys 29 3 between between IN cord-304556-1f47gvys 29 4 apoptotic apoptotic JJ cord-304556-1f47gvys 29 5 and and CC cord-304556-1f47gvys 29 6 healthy healthy JJ cord-304556-1f47gvys 29 7 cells cell NNS cord-304556-1f47gvys 29 8 is be VBZ cord-304556-1f47gvys 29 9 mediated mediate VBN cord-304556-1f47gvys 29 10 primarily primarily RB cord-304556-1f47gvys 29 11 by by IN cord-304556-1f47gvys 29 12 the the DT cord-304556-1f47gvys 29 13 release release NN cord-304556-1f47gvys 29 14 of of IN cord-304556-1f47gvys 29 15 ' ' `` cord-304556-1f47gvys 29 16 find find VB cord-304556-1f47gvys 29 17 - - HYPH cord-304556-1f47gvys 29 18 me -PRON- PRP cord-304556-1f47gvys 29 19 ' ' POS cord-304556-1f47gvys 29 20 signals signal NNS cord-304556-1f47gvys 29 21 from from IN cord-304556-1f47gvys 29 22 apoptotic apoptotic JJ cord-304556-1f47gvys 29 23 cells cell NNS cord-304556-1f47gvys 29 24 that that WDT cord-304556-1f47gvys 29 25 include include VBP cord-304556-1f47gvys 29 26 ATP ATP NNP cord-304556-1f47gvys 29 27 and and CC cord-304556-1f47gvys 29 28 UTP UTP NNP cord-304556-1f47gvys 29 29 [ [ -LRB- cord-304556-1f47gvys 29 30 3 3 CD cord-304556-1f47gvys 29 31 ] ] -RRB- cord-304556-1f47gvys 29 32 , , , cord-304556-1f47gvys 29 33 fractalkine fractalkine FW cord-304556-1f47gvys 29 34 ( ( -LRB- cord-304556-1f47gvys 29 35 CX3CL1 cx3cl1 NN cord-304556-1f47gvys 29 36 ) ) -RRB- cord-304556-1f47gvys 29 37 [ [ -LRB- cord-304556-1f47gvys 29 38 4 4 CD cord-304556-1f47gvys 29 39 ] ] -RRB- cord-304556-1f47gvys 29 40 , , , cord-304556-1f47gvys 29 41 lysophosphatidylcholine lysophosphatidylcholine NNP cord-304556-1f47gvys 29 42 [ [ -LRB- cord-304556-1f47gvys 29 43 5 5 CD cord-304556-1f47gvys 29 44 ] ] -RRB- cord-304556-1f47gvys 29 45 and and CC cord-304556-1f47gvys 29 46 sphingosine-1-phosphate sphingosine-1-phosphate NNP cord-304556-1f47gvys 29 47 [ [ -LRB- cord-304556-1f47gvys 29 48 6 6 CD cord-304556-1f47gvys 29 49 ] ] -RRB- cord-304556-1f47gvys 29 50 . . . cord-304556-1f47gvys 30 1 In in IN cord-304556-1f47gvys 30 2 addition addition NN cord-304556-1f47gvys 30 3 to to IN cord-304556-1f47gvys 30 4 recruitment recruitment NN cord-304556-1f47gvys 30 5 , , , cord-304556-1f47gvys 30 6 such such JJ cord-304556-1f47gvys 30 7 soluble soluble JJ cord-304556-1f47gvys 30 8 signals signal NNS cord-304556-1f47gvys 30 9 may may MD cord-304556-1f47gvys 30 10 also also RB cord-304556-1f47gvys 30 11 enhance enhance VB cord-304556-1f47gvys 30 12 the the DT cord-304556-1f47gvys 30 13 engulfment engulfment NN cord-304556-1f47gvys 30 14 capacity capacity NN cord-304556-1f47gvys 30 15 of of IN cord-304556-1f47gvys 30 16 the the DT cord-304556-1f47gvys 30 17 responding respond VBG cord-304556-1f47gvys 30 18 cell cell NN cord-304556-1f47gvys 30 19 . . . cord-304556-1f47gvys 31 1 For for IN cord-304556-1f47gvys 31 2 example example NN cord-304556-1f47gvys 31 3 , , , cord-304556-1f47gvys 31 4 apoptotic apoptotic JJ cord-304556-1f47gvys 31 5 cell cell NN cord-304556-1f47gvys 31 6 production production NN cord-304556-1f47gvys 31 7 of of IN cord-304556-1f47gvys 31 8 fractalkine fractalkine NNP cord-304556-1f47gvys 31 9 induces induce VBZ cord-304556-1f47gvys 31 10 milk milk NN cord-304556-1f47gvys 31 11 fat fat NN cord-304556-1f47gvys 31 12 globule globule NN cord-304556-1f47gvys 31 13 - - HYPH cord-304556-1f47gvys 31 14 epidermal epidermal VBG cord-304556-1f47gvys 31 15 growth growth NN cord-304556-1f47gvys 31 16 factor factor NN cord-304556-1f47gvys 31 17 8 8 CD cord-304556-1f47gvys 32 1 ( ( -LRB- cord-304556-1f47gvys 32 2 MFG MFG NNP cord-304556-1f47gvys 32 3 - - HYPH cord-304556-1f47gvys 32 4 E8 E8 NNP cord-304556-1f47gvys 32 5 ) ) -RRB- cord-304556-1f47gvys 32 6 expression expression NN cord-304556-1f47gvys 32 7 in in IN cord-304556-1f47gvys 32 8 phagocytes phagocyte NNS cord-304556-1f47gvys 32 9 that that WDT cord-304556-1f47gvys 32 10 enhances enhance VBZ cord-304556-1f47gvys 32 11 apoptotic apoptotic JJ cord-304556-1f47gvys 32 12 cell cell NN cord-304556-1f47gvys 32 13 clearance clearance NN cord-304556-1f47gvys 32 14 [ [ -LRB- cord-304556-1f47gvys 32 15 7 7 CD cord-304556-1f47gvys 32 16 ] ] -RRB- cord-304556-1f47gvys 32 17 . . . cord-304556-1f47gvys 33 1 Apoptotic apoptotic JJ cord-304556-1f47gvys 33 2 cells cell NNS cord-304556-1f47gvys 33 3 expose expose VBP cord-304556-1f47gvys 33 4 a a DT cord-304556-1f47gvys 33 5 variety variety NN cord-304556-1f47gvys 33 6 of of IN cord-304556-1f47gvys 33 7 molecules molecule NNS cord-304556-1f47gvys 33 8 on on IN cord-304556-1f47gvys 33 9 their -PRON- PRP$ cord-304556-1f47gvys 33 10 cell cell NN cord-304556-1f47gvys 33 11 surface surface NN cord-304556-1f47gvys 33 12 that that WDT cord-304556-1f47gvys 33 13 can can MD cord-304556-1f47gvys 33 14 be be VB cord-304556-1f47gvys 33 15 recognised recognise VBN cord-304556-1f47gvys 33 16 by by IN cord-304556-1f47gvys 33 17 receptors receptor NNS cord-304556-1f47gvys 33 18 on on IN cord-304556-1f47gvys 33 19 phagocytic phagocytic JJ cord-304556-1f47gvys 33 20 cells cell NNS cord-304556-1f47gvys 33 21 . . . cord-304556-1f47gvys 34 1 The the DT cord-304556-1f47gvys 34 2 precise precise JJ cord-304556-1f47gvys 34 3 composition composition NN cord-304556-1f47gvys 34 4 of of IN cord-304556-1f47gvys 34 5 such such JJ cord-304556-1f47gvys 34 6 ' ' `` cord-304556-1f47gvys 34 7 eat eat VB cord-304556-1f47gvys 34 8 - - HYPH cord-304556-1f47gvys 34 9 me -PRON- PRP cord-304556-1f47gvys 34 10 ' ' POS cord-304556-1f47gvys 34 11 signals signal NNS cord-304556-1f47gvys 34 12 likely likely RB cord-304556-1f47gvys 34 13 depends depend VBZ cord-304556-1f47gvys 34 14 on on IN cord-304556-1f47gvys 34 15 whether whether IN cord-304556-1f47gvys 34 16 apoptosis apoptosis NN cord-304556-1f47gvys 34 17 is be VBZ cord-304556-1f47gvys 34 18 occurring occur VBG cord-304556-1f47gvys 34 19 under under IN cord-304556-1f47gvys 34 20 homeostatic homeostatic JJ cord-304556-1f47gvys 34 21 conditions condition NNS cord-304556-1f47gvys 34 22 or or CC cord-304556-1f47gvys 34 23 during during IN cord-304556-1f47gvys 34 24 inflammation inflammation NN cord-304556-1f47gvys 34 25 and and CC cord-304556-1f47gvys 34 26 is be VBZ cord-304556-1f47gvys 34 27 tissue tissue NN cord-304556-1f47gvys 34 28 - - HYPH cord-304556-1f47gvys 34 29 and and CC cord-304556-1f47gvys 34 30 cell cell NN cord-304556-1f47gvys 34 31 type type NN cord-304556-1f47gvys 34 32 - - HYPH cord-304556-1f47gvys 34 33 specific specific JJ cord-304556-1f47gvys 34 34 [ [ -LRB- cord-304556-1f47gvys 34 35 1 1 CD cord-304556-1f47gvys 34 36 , , , cord-304556-1f47gvys 34 37 8 8 CD cord-304556-1f47gvys 34 38 ] ] -RRB- cord-304556-1f47gvys 34 39 . . . cord-304556-1f47gvys 35 1 One one CD cord-304556-1f47gvys 35 2 of of IN cord-304556-1f47gvys 35 3 the the DT cord-304556-1f47gvys 35 4 best well RBS cord-304556-1f47gvys 35 5 studied study VBN cord-304556-1f47gvys 35 6 ' ' '' cord-304556-1f47gvys 35 7 eat eat VB cord-304556-1f47gvys 35 8 - - HYPH cord-304556-1f47gvys 35 9 me -PRON- PRP cord-304556-1f47gvys 35 10 ' ' POS cord-304556-1f47gvys 35 11 signals signal NNS cord-304556-1f47gvys 35 12 is be VBZ cord-304556-1f47gvys 35 13 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 35 14 ( ( -LRB- cord-304556-1f47gvys 35 15 PtdSer PtdSer NNP cord-304556-1f47gvys 35 16 ) ) -RRB- cord-304556-1f47gvys 35 17 that that IN cord-304556-1f47gvys 35 18 in in IN cord-304556-1f47gvys 35 19 living living NN cord-304556-1f47gvys 35 20 cells cell NNS cord-304556-1f47gvys 35 21 is be VBZ cord-304556-1f47gvys 35 22 localised localised JJ cord-304556-1f47gvys 35 23 to to IN cord-304556-1f47gvys 35 24 the the DT cord-304556-1f47gvys 35 25 inner inner JJ cord-304556-1f47gvys 35 26 leaflet leaflet NN cord-304556-1f47gvys 35 27 of of IN cord-304556-1f47gvys 35 28 the the DT cord-304556-1f47gvys 35 29 plasma plasma NN cord-304556-1f47gvys 35 30 membrane membrane NN cord-304556-1f47gvys 35 31 and and CC cord-304556-1f47gvys 35 32 is be VBZ cord-304556-1f47gvys 35 33 externalised externalise VBN cord-304556-1f47gvys 35 34 upon upon IN cord-304556-1f47gvys 35 35 induction induction NN cord-304556-1f47gvys 35 36 of of IN cord-304556-1f47gvys 35 37 apoptosis apoptosis NN cord-304556-1f47gvys 35 38 [ [ -LRB- cord-304556-1f47gvys 35 39 9 9 CD cord-304556-1f47gvys 35 40 ] ] -RRB- cord-304556-1f47gvys 35 41 . . . cord-304556-1f47gvys 36 1 Overexpression Overexpression NNP cord-304556-1f47gvys 36 2 of of IN cord-304556-1f47gvys 36 3 PtdSer PtdSer NNP cord-304556-1f47gvys 36 4 enhances enhance VBZ cord-304556-1f47gvys 36 5 apoptotic apoptotic JJ cord-304556-1f47gvys 36 6 cell cell NN cord-304556-1f47gvys 36 7 engulfment engulfment NN cord-304556-1f47gvys 36 8 , , , cord-304556-1f47gvys 36 9 whereas whereas IN cord-304556-1f47gvys 36 10 PtdSer PtdSer NNP cord-304556-1f47gvys 36 11 blockade blockade NN cord-304556-1f47gvys 36 12 suppresses suppress VBZ cord-304556-1f47gvys 36 13 this this DT cord-304556-1f47gvys 36 14 process process NN cord-304556-1f47gvys 36 15 , , , cord-304556-1f47gvys 36 16 leading lead VBG cord-304556-1f47gvys 36 17 to to IN cord-304556-1f47gvys 36 18 autoimmunity autoimmunity NN cord-304556-1f47gvys 36 19 [ [ -LRB- cord-304556-1f47gvys 36 20 10 10 CD cord-304556-1f47gvys 36 21 , , , cord-304556-1f47gvys 36 22 11 11 CD cord-304556-1f47gvys 36 23 ] ] -RRB- cord-304556-1f47gvys 36 24 . . . cord-304556-1f47gvys 37 1 Irreversible irreversible JJ cord-304556-1f47gvys 37 2 externalisation externalisation NN cord-304556-1f47gvys 37 3 occurs occur VBZ cord-304556-1f47gvys 37 4 when when WRB cord-304556-1f47gvys 37 5 caspases caspase NNS cord-304556-1f47gvys 37 6 inactivate inactivate VBP cord-304556-1f47gvys 37 7 flippase flippase NNP cord-304556-1f47gvys 37 8 ( ( -LRB- cord-304556-1f47gvys 37 9 ATP11C ATP11C NNP cord-304556-1f47gvys 37 10 ) ) -RRB- cord-304556-1f47gvys 37 11 that that IN cord-304556-1f47gvys 37 12 in in IN cord-304556-1f47gvys 37 13 healthy healthy JJ cord-304556-1f47gvys 37 14 cells cell NNS cord-304556-1f47gvys 37 15 continually continually RB cord-304556-1f47gvys 37 16 flips flip VBZ cord-304556-1f47gvys 37 17 PtdSer PtdSer NNP cord-304556-1f47gvys 37 18 in in IN cord-304556-1f47gvys 37 19 the the DT cord-304556-1f47gvys 37 20 plasma plasma NN cord-304556-1f47gvys 37 21 membrane membrane NN cord-304556-1f47gvys 37 22 [ [ -LRB- cord-304556-1f47gvys 37 23 12 12 CD cord-304556-1f47gvys 37 24 ] ] -RRB- cord-304556-1f47gvys 37 25 . . . cord-304556-1f47gvys 38 1 At at IN cord-304556-1f47gvys 38 2 the the DT cord-304556-1f47gvys 38 3 same same JJ cord-304556-1f47gvys 38 4 time time NN cord-304556-1f47gvys 38 5 , , , cord-304556-1f47gvys 38 6 caspase caspase NN cord-304556-1f47gvys 38 7 - - HYPH cord-304556-1f47gvys 38 8 dependent dependent JJ cord-304556-1f47gvys 38 9 activation activation NN cord-304556-1f47gvys 38 10 of of IN cord-304556-1f47gvys 38 11 scramblases scramblase NNS cord-304556-1f47gvys 38 12 ( ( -LRB- cord-304556-1f47gvys 38 13 such such JJ cord-304556-1f47gvys 38 14 as as IN cord-304556-1f47gvys 38 15 Xkr8 Xkr8 NNP cord-304556-1f47gvys 38 16 ) ) -RRB- cord-304556-1f47gvys 38 17 , , , cord-304556-1f47gvys 38 18 which which WDT cord-304556-1f47gvys 38 19 non non NNS cord-304556-1f47gvys 38 20 - - VBP cord-304556-1f47gvys 38 21 specifically specifically RB cord-304556-1f47gvys 38 22 and and CC cord-304556-1f47gvys 38 23 bi bi JJ cord-304556-1f47gvys 38 24 - - JJ cord-304556-1f47gvys 38 25 directionally directionally RB cord-304556-1f47gvys 38 26 scramble scramble VBP cord-304556-1f47gvys 38 27 phospholipids phospholipid NNS cord-304556-1f47gvys 38 28 in in IN cord-304556-1f47gvys 38 29 the the DT cord-304556-1f47gvys 38 30 plasma plasma NN cord-304556-1f47gvys 38 31 membrane membrane NN cord-304556-1f47gvys 38 32 , , , cord-304556-1f47gvys 38 33 is be VBZ cord-304556-1f47gvys 38 34 also also RB cord-304556-1f47gvys 38 35 required require VBN cord-304556-1f47gvys 38 36 for for IN cord-304556-1f47gvys 38 37 PtdSer ptdser JJ cord-304556-1f47gvys 38 38 exposure exposure NN cord-304556-1f47gvys 38 39 on on IN cord-304556-1f47gvys 38 40 apoptotic apoptotic JJ cord-304556-1f47gvys 38 41 cells cell NNS cord-304556-1f47gvys 38 42 [ [ -LRB- cord-304556-1f47gvys 38 43 13 13 CD cord-304556-1f47gvys 38 44 ] ] -RRB- cord-304556-1f47gvys 38 45 . . . cord-304556-1f47gvys 39 1 PtdSer PtdSer NNP cord-304556-1f47gvys 39 2 is be VBZ cord-304556-1f47gvys 39 3 transiently transiently RB cord-304556-1f47gvys 39 4 exposed expose VBN cord-304556-1f47gvys 39 5 on on IN cord-304556-1f47gvys 39 6 the the DT cord-304556-1f47gvys 39 7 surface surface NN cord-304556-1f47gvys 39 8 of of IN cord-304556-1f47gvys 39 9 living living NN cord-304556-1f47gvys 39 10 cells cell NNS cord-304556-1f47gvys 39 11 that that WDT cord-304556-1f47gvys 39 12 resist resist VBP cord-304556-1f47gvys 39 13 efferocytosis efferocytosis NN cord-304556-1f47gvys 39 14 , , , cord-304556-1f47gvys 39 15 suggesting suggest VBG cord-304556-1f47gvys 39 16 that that IN cord-304556-1f47gvys 39 17 this this DT cord-304556-1f47gvys 39 18 signal signal NN cord-304556-1f47gvys 39 19 alone alone RB cord-304556-1f47gvys 39 20 may may MD cord-304556-1f47gvys 39 21 not not RB cord-304556-1f47gvys 39 22 be be VB cord-304556-1f47gvys 39 23 enough enough JJ cord-304556-1f47gvys 39 24 , , , cord-304556-1f47gvys 39 25 or or CC cord-304556-1f47gvys 39 26 that that IN cord-304556-1f47gvys 39 27 prolonged prolong VBN cord-304556-1f47gvys 39 28 interaction interaction NN cord-304556-1f47gvys 39 29 of of IN cord-304556-1f47gvys 39 30 PtdSer ptdser JJ cord-304556-1f47gvys 39 31 receptors receptor NNS cord-304556-1f47gvys 39 32 on on IN cord-304556-1f47gvys 39 33 phagocytes phagocyte NNS cord-304556-1f47gvys 39 34 is be VBZ cord-304556-1f47gvys 39 35 required require VBN cord-304556-1f47gvys 39 36 [ [ -LRB- cord-304556-1f47gvys 39 37 14 14 CD cord-304556-1f47gvys 39 38 ] ] -RRB- cord-304556-1f47gvys 39 39 . . . cord-304556-1f47gvys 40 1 Oxidised oxidise VBN cord-304556-1f47gvys 40 2 low low JJ cord-304556-1f47gvys 40 3 - - HYPH cord-304556-1f47gvys 40 4 density density NN cord-304556-1f47gvys 40 5 lipoprotein lipoprotein NN cord-304556-1f47gvys 40 6 , , , cord-304556-1f47gvys 40 7 calreticulin calreticulin NNP cord-304556-1f47gvys 40 8 , , , cord-304556-1f47gvys 40 9 annexin annexin NNP cord-304556-1f47gvys 40 10 A1 A1 NNP cord-304556-1f47gvys 40 11 , , , cord-304556-1f47gvys 40 12 ICAM3 ICAM3 VBN cord-304556-1f47gvys 40 13 , , , cord-304556-1f47gvys 40 14 C1q C1q NNP cord-304556-1f47gvys 40 15 and and CC cord-304556-1f47gvys 40 16 thrombospondin-1 thrombospondin-1 NNP cord-304556-1f47gvys 40 17 ( ( -LRB- cord-304556-1f47gvys 40 18 TSP1 TSP1 NNP cord-304556-1f47gvys 40 19 ) ) -RRB- cord-304556-1f47gvys 40 20 are be VBP cord-304556-1f47gvys 40 21 also also RB cord-304556-1f47gvys 40 22 implicated implicate VBN cord-304556-1f47gvys 40 23 in in IN cord-304556-1f47gvys 40 24 efferocytosis efferocytosis NN cord-304556-1f47gvys 40 25 [ [ -LRB- cord-304556-1f47gvys 40 26 1 1 CD cord-304556-1f47gvys 40 27 ] ] -RRB- cord-304556-1f47gvys 40 28 . . . cord-304556-1f47gvys 41 1 Furthermore furthermore RB cord-304556-1f47gvys 41 2 , , , cord-304556-1f47gvys 41 3 healthy healthy JJ cord-304556-1f47gvys 41 4 cells cell NNS cord-304556-1f47gvys 41 5 prevent prevent VBP cord-304556-1f47gvys 41 6 engulfment engulfment NN cord-304556-1f47gvys 41 7 by by IN cord-304556-1f47gvys 41 8 expressing express VBG cord-304556-1f47gvys 41 9 CD47 CD47 NNP cord-304556-1f47gvys 41 10 and and CC cord-304556-1f47gvys 41 11 CD31 CD31 NNP cord-304556-1f47gvys 41 12 [ [ -LRB- cord-304556-1f47gvys 41 13 15 15 CD cord-304556-1f47gvys 41 14 , , , cord-304556-1f47gvys 41 15 16 16 CD cord-304556-1f47gvys 41 16 ] ] -RRB- cord-304556-1f47gvys 41 17 or or CC cord-304556-1f47gvys 41 18 by by IN cord-304556-1f47gvys 41 19 ligating ligate VBG cord-304556-1f47gvys 41 20 CD300a CD300a NNP cord-304556-1f47gvys 41 21 that that WDT cord-304556-1f47gvys 41 22 impedes impede VBZ cord-304556-1f47gvys 41 23 macrophage macrophage NN cord-304556-1f47gvys 41 24 function function NN cord-304556-1f47gvys 41 25 [ [ -LRB- cord-304556-1f47gvys 41 26 17 17 CD cord-304556-1f47gvys 41 27 ] ] -RRB- cord-304556-1f47gvys 41 28 . . . cord-304556-1f47gvys 42 1 A a DT cord-304556-1f47gvys 42 2 balance balance NN cord-304556-1f47gvys 42 3 of of IN cord-304556-1f47gvys 42 4 efferocytosis efferocytosis NN cord-304556-1f47gvys 42 5 - - HYPH cord-304556-1f47gvys 42 6 inducing induce VBG cord-304556-1f47gvys 42 7 and and CC cord-304556-1f47gvys 42 8 inhibitory inhibitory JJ cord-304556-1f47gvys 42 9 signals signal NNS cord-304556-1f47gvys 42 10 may may MD cord-304556-1f47gvys 42 11 therefore therefore RB cord-304556-1f47gvys 42 12 determine determine VB cord-304556-1f47gvys 42 13 apoptotic apoptotic JJ cord-304556-1f47gvys 42 14 cell cell NN cord-304556-1f47gvys 42 15 clearance clearance NN cord-304556-1f47gvys 42 16 . . . cord-304556-1f47gvys 43 1 PtdSer ptdser JJ cord-304556-1f47gvys 43 2 and and CC cord-304556-1f47gvys 43 3 other other JJ cord-304556-1f47gvys 43 4 ' ' `` cord-304556-1f47gvys 43 5 eat eat VB cord-304556-1f47gvys 43 6 - - HYPH cord-304556-1f47gvys 43 7 me -PRON- PRP cord-304556-1f47gvys 43 8 ' ' POS cord-304556-1f47gvys 43 9 signals signal NNS cord-304556-1f47gvys 43 10 exposed expose VBN cord-304556-1f47gvys 43 11 on on IN cord-304556-1f47gvys 43 12 apoptotic apoptotic JJ cord-304556-1f47gvys 43 13 cells cell NNS cord-304556-1f47gvys 43 14 bind bind VBP cord-304556-1f47gvys 43 15 a a DT cord-304556-1f47gvys 43 16 plethora plethora NN cord-304556-1f47gvys 43 17 of of IN cord-304556-1f47gvys 43 18 receptors receptor NNS cord-304556-1f47gvys 43 19 on on IN cord-304556-1f47gvys 43 20 phagocytic phagocytic JJ cord-304556-1f47gvys 43 21 cells cell NNS cord-304556-1f47gvys 43 22 , , , cord-304556-1f47gvys 43 23 a a DT cord-304556-1f47gvys 43 24 number number NN cord-304556-1f47gvys 43 25 of of IN cord-304556-1f47gvys 43 26 which which WDT cord-304556-1f47gvys 43 27 have have VBP cord-304556-1f47gvys 43 28 been be VBN cord-304556-1f47gvys 43 29 identified identify VBN cord-304556-1f47gvys 43 30 in in IN cord-304556-1f47gvys 43 31 the the DT cord-304556-1f47gvys 43 32 lung lung NN cord-304556-1f47gvys 43 33 ( ( -LRB- cord-304556-1f47gvys 43 34 Table table NN cord-304556-1f47gvys 43 35 1 1 CD cord-304556-1f47gvys 43 36 ) ) -RRB- cord-304556-1f47gvys 43 37 . . . cord-304556-1f47gvys 44 1 Externalised Externalised NNP cord-304556-1f47gvys 44 2 PtdSer PtdSer NNP cord-304556-1f47gvys 44 3 is be VBZ cord-304556-1f47gvys 44 4 recognised recognise VBN cord-304556-1f47gvys 44 5 directly directly RB cord-304556-1f47gvys 44 6 by by IN cord-304556-1f47gvys 44 7 triggering trigger VBG cord-304556-1f47gvys 44 8 receptor receptor NN cord-304556-1f47gvys 44 9 expressed express VBN cord-304556-1f47gvys 44 10 by by IN cord-304556-1f47gvys 44 11 myeloid myeloid NN cord-304556-1f47gvys 44 12 cells-2 cells-2 NNP cord-304556-1f47gvys 44 13 ( ( -LRB- cord-304556-1f47gvys 44 14 TREM2 TREM2 NNP cord-304556-1f47gvys 44 15 ) ) -RRB- cord-304556-1f47gvys 44 16 [ [ -LRB- cord-304556-1f47gvys 44 17 30 30 CD cord-304556-1f47gvys 44 18 ] ] -RRB- cord-304556-1f47gvys 44 19 , , . cord-304556-1f47gvys 45 1 CD300 CD300 NNP cord-304556-1f47gvys 45 2 [ [ -LRB- cord-304556-1f47gvys 45 3 31 31 CD cord-304556-1f47gvys 45 4 ] ] -RRB- cord-304556-1f47gvys 45 5 , , , cord-304556-1f47gvys 45 6 receptor receptor NN cord-304556-1f47gvys 45 7 for for IN cord-304556-1f47gvys 45 8 advanced advanced JJ cord-304556-1f47gvys 45 9 glycation glycation NN cord-304556-1f47gvys 45 10 end end NN cord-304556-1f47gvys 45 11 products product NNS cord-304556-1f47gvys 45 12 ( ( -LRB- cord-304556-1f47gvys 45 13 RAGE rage NN cord-304556-1f47gvys 45 14 ) ) -RRB- cord-304556-1f47gvys 45 15 [ [ -LRB- cord-304556-1f47gvys 45 16 32 32 CD cord-304556-1f47gvys 45 17 ] ] -RRB- cord-304556-1f47gvys 45 18 , , , cord-304556-1f47gvys 45 19 stabilin-2 stabilin-2 NNP cord-304556-1f47gvys 45 20 [ [ -LRB- cord-304556-1f47gvys 45 21 33 33 CD cord-304556-1f47gvys 45 22 ] ] -RRB- cord-304556-1f47gvys 45 23 , , , cord-304556-1f47gvys 45 24 brain brain NN cord-304556-1f47gvys 45 25 - - HYPH cord-304556-1f47gvys 45 26 specific specific JJ cord-304556-1f47gvys 45 27 angiogenesis angiogenesis NN cord-304556-1f47gvys 45 28 inhibitor-1 inhibitor-1 NNP cord-304556-1f47gvys 45 29 ( ( -LRB- cord-304556-1f47gvys 45 30 BAI1 BAI1 NNP cord-304556-1f47gvys 45 31 ) ) -RRB- cord-304556-1f47gvys 46 1 [ [ -LRB- cord-304556-1f47gvys 46 2 34 34 CD cord-304556-1f47gvys 46 3 ] ] -RRB- cord-304556-1f47gvys 46 4 and and CC cord-304556-1f47gvys 46 5 the the DT cord-304556-1f47gvys 46 6 family family NN cord-304556-1f47gvys 46 7 of of IN cord-304556-1f47gvys 46 8 T T NNP cord-304556-1f47gvys 46 9 cell cell NN cord-304556-1f47gvys 46 10 / / SYM cord-304556-1f47gvys 46 11 transmembrane transmembrane NN cord-304556-1f47gvys 46 12 , , , cord-304556-1f47gvys 46 13 immunoglobulin immunoglobulin NN cord-304556-1f47gvys 46 14 , , , cord-304556-1f47gvys 46 15 and and CC cord-304556-1f47gvys 46 16 mucin mucin NN cord-304556-1f47gvys 46 17 ( ( -LRB- cord-304556-1f47gvys 46 18 TIM TIM NNP cord-304556-1f47gvys 46 19 ) ) -RRB- cord-304556-1f47gvys 46 20 receptors receptor NNS cord-304556-1f47gvys 46 21 , , , cord-304556-1f47gvys 46 22 which which WDT cord-304556-1f47gvys 46 23 includes include VBZ cord-304556-1f47gvys 46 24 TIM-1 TIM-1 NNP cord-304556-1f47gvys 46 25 , , , cord-304556-1f47gvys 46 26 3 3 CD cord-304556-1f47gvys 46 27 and and CC cord-304556-1f47gvys 46 28 4 4 CD cord-304556-1f47gvys 46 29 [ [ -LRB- cord-304556-1f47gvys 46 30 35 35 CD cord-304556-1f47gvys 46 31 , , , cord-304556-1f47gvys 46 32 36 36 CD cord-304556-1f47gvys 46 33 ] ] -RRB- cord-304556-1f47gvys 46 34 . . . cord-304556-1f47gvys 47 1 Other other JJ cord-304556-1f47gvys 47 2 engulfment engulfment NN cord-304556-1f47gvys 47 3 receptors receptor NNS cord-304556-1f47gvys 47 4 require require VBP cord-304556-1f47gvys 47 5 bridging bridge VBG cord-304556-1f47gvys 47 6 molecules molecule NNS cord-304556-1f47gvys 47 7 to to TO cord-304556-1f47gvys 47 8 link link VB cord-304556-1f47gvys 47 9 them -PRON- PRP cord-304556-1f47gvys 47 10 to to IN cord-304556-1f47gvys 47 11 externalised externalise VBN cord-304556-1f47gvys 47 12 PtdSer PtdSer NNP cord-304556-1f47gvys 47 13 . . . cord-304556-1f47gvys 48 1 For for IN cord-304556-1f47gvys 48 2 example example NN cord-304556-1f47gvys 48 3 , , , cord-304556-1f47gvys 48 4 integrin integrin NN cord-304556-1f47gvys 48 5 αvβ3 αvβ3 NN cord-304556-1f47gvys 48 6 or or CC cord-304556-1f47gvys 48 7 αvβ5 αvβ5 NN cord-304556-1f47gvys 48 8 requires require VBZ cord-304556-1f47gvys 48 9 MFG MFG NNP cord-304556-1f47gvys 48 10 - - HYPH cord-304556-1f47gvys 48 11 E8 E8 NNP cord-304556-1f47gvys 48 12 , , , cord-304556-1f47gvys 48 13 while while IN cord-304556-1f47gvys 48 14 Tyro3 Tyro3 NNP cord-304556-1f47gvys 48 15 , , , cord-304556-1f47gvys 48 16 Axl Axl NNP cord-304556-1f47gvys 48 17 and and CC cord-304556-1f47gvys 48 18 MerTK mertk NN cord-304556-1f47gvys 48 19 that that WDT cord-304556-1f47gvys 48 20 form form VBP cord-304556-1f47gvys 48 21 the the DT cord-304556-1f47gvys 48 22 TAM TAM NNP cord-304556-1f47gvys 48 23 receptor receptor NN cord-304556-1f47gvys 48 24 tyrosine tyrosine NN cord-304556-1f47gvys 48 25 kinase kinase NN cord-304556-1f47gvys 48 26 family family NN cord-304556-1f47gvys 49 1 [ [ -LRB- cord-304556-1f47gvys 49 2 37 37 CD cord-304556-1f47gvys 49 3 ] ] -RRB- cord-304556-1f47gvys 49 4 require require VB cord-304556-1f47gvys 49 5 the the DT cord-304556-1f47gvys 49 6 bridging bridge VBG cord-304556-1f47gvys 49 7 molecules molecule NNS cord-304556-1f47gvys 49 8 Protein Protein NNP cord-304556-1f47gvys 49 9 S S NNP cord-304556-1f47gvys 49 10 or or CC cord-304556-1f47gvys 50 1 growth growth NN cord-304556-1f47gvys 50 2 arrest arrest NN cord-304556-1f47gvys 50 3 specific specific JJ cord-304556-1f47gvys 50 4 6 6 CD cord-304556-1f47gvys 51 1 ( ( -LRB- cord-304556-1f47gvys 51 2 Gas6 gas6 NN cord-304556-1f47gvys 51 3 ) ) -RRB- cord-304556-1f47gvys 51 4 [ [ -LRB- cord-304556-1f47gvys 51 5 38 38 CD cord-304556-1f47gvys 51 6 ] ] -RRB- cord-304556-1f47gvys 51 7 . . . cord-304556-1f47gvys 52 1 The the DT cord-304556-1f47gvys 52 2 N N NNP cord-304556-1f47gvys 52 3 - - HYPH cord-304556-1f47gvys 52 4 terminal terminal NN cord-304556-1f47gvys 52 5 Gla Gla NNP cord-304556-1f47gvys 52 6 domains domain NNS cord-304556-1f47gvys 52 7 of of IN cord-304556-1f47gvys 52 8 Protein Protein NNP cord-304556-1f47gvys 52 9 S S NNP cord-304556-1f47gvys 52 10 and and CC cord-304556-1f47gvys 52 11 Gas6 Gas6 NNP cord-304556-1f47gvys 52 12 bridge bridge NN cord-304556-1f47gvys 52 13 TAM tam NN cord-304556-1f47gvys 52 14 receptors receptor NNS cord-304556-1f47gvys 52 15 to to IN cord-304556-1f47gvys 52 16 PtdSer PtdSer NNP cord-304556-1f47gvys 52 17 on on IN cord-304556-1f47gvys 52 18 the the DT cord-304556-1f47gvys 52 19 surface surface NN cord-304556-1f47gvys 52 20 of of IN cord-304556-1f47gvys 52 21 apoptotic apoptotic JJ cord-304556-1f47gvys 52 22 cells cell NNS cord-304556-1f47gvys 52 23 [ [ -LRB- cord-304556-1f47gvys 52 24 39 39 CD cord-304556-1f47gvys 52 25 ] ] -RRB- cord-304556-1f47gvys 52 26 , , , cord-304556-1f47gvys 52 27 whereas whereas IN cord-304556-1f47gvys 52 28 the the DT cord-304556-1f47gvys 52 29 C C NNP cord-304556-1f47gvys 52 30 - - HYPH cord-304556-1f47gvys 52 31 terminal terminal NN cord-304556-1f47gvys 52 32 sex sex NN cord-304556-1f47gvys 52 33 hormone hormone NN cord-304556-1f47gvys 52 34 - - HYPH cord-304556-1f47gvys 52 35 binding bind VBG cord-304556-1f47gvys 52 36 globulin globulin NN cord-304556-1f47gvys 52 37 - - HYPH cord-304556-1f47gvys 52 38 like like JJ cord-304556-1f47gvys 52 39 domains domain NNS cord-304556-1f47gvys 52 40 bind bind VBP cord-304556-1f47gvys 52 41 and and CC cord-304556-1f47gvys 52 42 activate activate VBP cord-304556-1f47gvys 52 43 the the DT cord-304556-1f47gvys 52 44 TAM TAM NNP cord-304556-1f47gvys 52 45 receptor receptor NN cord-304556-1f47gvys 52 46 [ [ -LRB- cord-304556-1f47gvys 52 47 40 40 CD cord-304556-1f47gvys 52 48 ] ] -RRB- cord-304556-1f47gvys 52 49 . . . cord-304556-1f47gvys 53 1 There there EX cord-304556-1f47gvys 53 2 are be VBP cord-304556-1f47gvys 53 3 also also RB cord-304556-1f47gvys 53 4 a a DT cord-304556-1f47gvys 53 5 number number NN cord-304556-1f47gvys 53 6 of of IN cord-304556-1f47gvys 53 7 receptors receptor NNS cord-304556-1f47gvys 53 8 that that WDT cord-304556-1f47gvys 53 9 recognise recognise VBP cord-304556-1f47gvys 53 10 other other JJ cord-304556-1f47gvys 53 11 externalised externalise VBN cord-304556-1f47gvys 53 12 ligands ligand NNS cord-304556-1f47gvys 53 13 including include VBG cord-304556-1f47gvys 53 14 scavenger scavenger NN cord-304556-1f47gvys 53 15 receptor receptor NN cord-304556-1f47gvys 53 16 class class NN cord-304556-1f47gvys 53 17 F f NN cord-304556-1f47gvys 53 18 , , , cord-304556-1f47gvys 53 19 member member NN cord-304556-1f47gvys 53 20 1 1 CD cord-304556-1f47gvys 53 21 ( ( -LRB- cord-304556-1f47gvys 53 22 SCARF1 SCARF1 NNP cord-304556-1f47gvys 53 23 ) ) -RRB- cord-304556-1f47gvys 53 24 and and CC cord-304556-1f47gvys 53 25 LDL LDL NNP cord-304556-1f47gvys 53 26 receptorrelated receptorrelate VBD cord-304556-1f47gvys 53 27 protein-1 protein-1 NNP cord-304556-1f47gvys 53 28 ( ( -LRB- cord-304556-1f47gvys 53 29 LRP-1 LRP-1 NNP cord-304556-1f47gvys 53 30 , , , cord-304556-1f47gvys 53 31 also also RB cord-304556-1f47gvys 53 32 known know VBN cord-304556-1f47gvys 53 33 as as IN cord-304556-1f47gvys 53 34 CD91 CD91 NNP cord-304556-1f47gvys 53 35 ) ) -RRB- cord-304556-1f47gvys 54 1 that that DT cord-304556-1f47gvys 54 2 recognise recognise VBP cord-304556-1f47gvys 54 3 C1q C1q NNP cord-304556-1f47gvys 54 4 and and CC cord-304556-1f47gvys 54 5 calreticulin calreticulin NNP cord-304556-1f47gvys 54 6 , , , cord-304556-1f47gvys 54 7 respectively respectively RB cord-304556-1f47gvys 54 8 , , , cord-304556-1f47gvys 54 9 CD36 CD36 NNP cord-304556-1f47gvys 54 10 together together RB cord-304556-1f47gvys 54 11 with with IN cord-304556-1f47gvys 54 12 integrin integrin NN cord-304556-1f47gvys 54 13 αvβ3 αvβ3 NN cord-304556-1f47gvys 54 14 or or CC cord-304556-1f47gvys 54 15 αvβ5 αvβ5 NN cord-304556-1f47gvys 54 16 that that DT cord-304556-1f47gvys 54 17 recognises recognise VBZ cord-304556-1f47gvys 54 18 TSP-1 TSP-1 NNP cord-304556-1f47gvys 54 19 , , , cord-304556-1f47gvys 54 20 CD14 CD14 NNP cord-304556-1f47gvys 54 21 that that WDT cord-304556-1f47gvys 54 22 binds bind VBZ cord-304556-1f47gvys 54 23 a a DT cord-304556-1f47gvys 54 24 modified modify VBN cord-304556-1f47gvys 54 25 form form NN cord-304556-1f47gvys 54 26 of of IN cord-304556-1f47gvys 54 27 the the DT cord-304556-1f47gvys 54 28 intracellular intracellular JJ cord-304556-1f47gvys 54 29 adhesion adhesion NN cord-304556-1f47gvys 54 30 molecule molecule NN cord-304556-1f47gvys 54 31 ICAM3 ICAM3 VBN cord-304556-1f47gvys 54 32 , , , cord-304556-1f47gvys 54 33 and and CC cord-304556-1f47gvys 54 34 lectin lectin NN cord-304556-1f47gvys 54 35 receptors receptor NNS cord-304556-1f47gvys 54 36 that that WDT cord-304556-1f47gvys 54 37 recognise recognise VBP cord-304556-1f47gvys 54 38 altered alter VBN cord-304556-1f47gvys 54 39 sugars sugar NNS cord-304556-1f47gvys 54 40 [ [ -LRB- cord-304556-1f47gvys 54 41 1 1 CD cord-304556-1f47gvys 54 42 ] ] -RRB- cord-304556-1f47gvys 54 43 . . . cord-304556-1f47gvys 55 1 The the DT cord-304556-1f47gvys 55 2 logic logic NN cord-304556-1f47gvys 55 3 behind behind IN cord-304556-1f47gvys 55 4 possessing possess VBG cord-304556-1f47gvys 55 5 so so RB cord-304556-1f47gvys 55 6 many many JJ cord-304556-1f47gvys 55 7 receptors receptor NNS cord-304556-1f47gvys 55 8 that that WDT cord-304556-1f47gvys 55 9 can can MD cord-304556-1f47gvys 55 10 recognise recognise VB cord-304556-1f47gvys 55 11 apoptotic apoptotic JJ cord-304556-1f47gvys 55 12 cells cell NNS cord-304556-1f47gvys 55 13 is be VBZ cord-304556-1f47gvys 55 14 not not RB cord-304556-1f47gvys 55 15 entirely entirely RB cord-304556-1f47gvys 55 16 clear clear JJ cord-304556-1f47gvys 55 17 . . . cord-304556-1f47gvys 56 1 Some some DT cord-304556-1f47gvys 56 2 , , , cord-304556-1f47gvys 56 3 such such JJ cord-304556-1f47gvys 56 4 as as IN cord-304556-1f47gvys 56 5 TIM-4 TIM-4 NNP cord-304556-1f47gvys 56 6 , , , cord-304556-1f47gvys 56 7 act act VBP cord-304556-1f47gvys 56 8 as as IN cord-304556-1f47gvys 56 9 tethering tether VBG cord-304556-1f47gvys 56 10 receptors receptor NNS cord-304556-1f47gvys 56 11 without without IN cord-304556-1f47gvys 56 12 any any DT cord-304556-1f47gvys 56 13 signalling signal VBG cord-304556-1f47gvys 56 14 consequences consequence NNS cord-304556-1f47gvys 56 15 [ [ -LRB- cord-304556-1f47gvys 56 16 41 41 CD cord-304556-1f47gvys 56 17 ] ] -RRB- cord-304556-1f47gvys 56 18 , , , cord-304556-1f47gvys 56 19 similar similar JJ cord-304556-1f47gvys 56 20 to to IN cord-304556-1f47gvys 56 21 CD14 CD14 NNP cord-304556-1f47gvys 56 22 [ [ -LRB- cord-304556-1f47gvys 56 23 42 42 CD cord-304556-1f47gvys 56 24 ] ] -RRB- cord-304556-1f47gvys 56 25 . . . cord-304556-1f47gvys 57 1 Different different JJ cord-304556-1f47gvys 57 2 receptors receptor NNS cord-304556-1f47gvys 57 3 may may MD cord-304556-1f47gvys 57 4 also also RB cord-304556-1f47gvys 57 5 act act VB cord-304556-1f47gvys 57 6 at at IN cord-304556-1f47gvys 57 7 different different JJ cord-304556-1f47gvys 57 8 stages stage NNS cord-304556-1f47gvys 57 9 of of IN cord-304556-1f47gvys 57 10 efferocytosis efferocytosis NN cord-304556-1f47gvys 57 11 [ [ -LRB- cord-304556-1f47gvys 57 12 43 43 CD cord-304556-1f47gvys 57 13 ] ] -RRB- cord-304556-1f47gvys 57 14 or or CC cord-304556-1f47gvys 57 15 may may MD cord-304556-1f47gvys 57 16 preferentially preferentially RB cord-304556-1f47gvys 57 17 clear clear VB cord-304556-1f47gvys 57 18 cells cell NNS cord-304556-1f47gvys 57 19 in in IN cord-304556-1f47gvys 57 20 different different JJ cord-304556-1f47gvys 57 21 locations location NNS cord-304556-1f47gvys 57 22 . . . cord-304556-1f47gvys 58 1 For for IN cord-304556-1f47gvys 58 2 example example NN cord-304556-1f47gvys 58 3 , , , cord-304556-1f47gvys 58 4 TREM2 TREM2 NNP cord-304556-1f47gvys 58 5 and and CC cord-304556-1f47gvys 58 6 TREM2-L TREM2-L NNP cord-304556-1f47gvys 58 7 form form VB cord-304556-1f47gvys 58 8 a a DT cord-304556-1f47gvys 58 9 receptor receptor NN cord-304556-1f47gvys 58 10 - - HYPH cord-304556-1f47gvys 58 11 ligand ligand NN cord-304556-1f47gvys 58 12 pair pair NN cord-304556-1f47gvys 58 13 connecting connect VBG cord-304556-1f47gvys 58 14 microglia microglia NNS cord-304556-1f47gvys 58 15 with with IN cord-304556-1f47gvys 58 16 apoptotic apoptotic JJ cord-304556-1f47gvys 58 17 neurons neuron NNS cord-304556-1f47gvys 58 18 , , , cord-304556-1f47gvys 58 19 directing direct VBG cord-304556-1f47gvys 58 20 removal removal NN cord-304556-1f47gvys 58 21 of of IN cord-304556-1f47gvys 58 22 damaged damaged JJ cord-304556-1f47gvys 58 23 cells cell NNS cord-304556-1f47gvys 58 24 to to TO cord-304556-1f47gvys 58 25 allow allow VB cord-304556-1f47gvys 58 26 repair repair NN cord-304556-1f47gvys 58 27 [ [ -LRB- cord-304556-1f47gvys 58 28 44 44 CD cord-304556-1f47gvys 58 29 ] ] -RRB- cord-304556-1f47gvys 58 30 . . . cord-304556-1f47gvys 59 1 It -PRON- PRP cord-304556-1f47gvys 59 2 is be VBZ cord-304556-1f47gvys 59 3 also also RB cord-304556-1f47gvys 59 4 likely likely JJ cord-304556-1f47gvys 59 5 that that IN cord-304556-1f47gvys 59 6 an an DT cord-304556-1f47gvys 59 7 alternate alternate JJ cord-304556-1f47gvys 59 8 outcome outcome NN cord-304556-1f47gvys 59 9 is be VBZ cord-304556-1f47gvys 59 10 required require VBN cord-304556-1f47gvys 59 11 upon upon IN cord-304556-1f47gvys 59 12 efferocytosis efferocytosis NN cord-304556-1f47gvys 59 13 that that WDT cord-304556-1f47gvys 59 14 requires require VBZ cord-304556-1f47gvys 59 15 linkage linkage NN cord-304556-1f47gvys 59 16 to to IN cord-304556-1f47gvys 59 17 different different JJ cord-304556-1f47gvys 59 18 signalling signal VBG cord-304556-1f47gvys 59 19 components component NNS cord-304556-1f47gvys 59 20 [ [ -LRB- cord-304556-1f47gvys 59 21 31 31 CD cord-304556-1f47gvys 59 22 ] ] -RRB- cord-304556-1f47gvys 59 23 . . . cord-304556-1f47gvys 60 1 With with IN cord-304556-1f47gvys 60 2 regard regard NN cord-304556-1f47gvys 60 3 to to IN cord-304556-1f47gvys 60 4 the the DT cord-304556-1f47gvys 60 5 TAM TAM NNP cord-304556-1f47gvys 60 6 receptors receptor NNS cord-304556-1f47gvys 60 7 , , , cord-304556-1f47gvys 60 8 MerTK mertk NN cord-304556-1f47gvys 60 9 is be VBZ cord-304556-1f47gvys 60 10 ubiquitously ubiquitously RB cord-304556-1f47gvys 60 11 expressed express VBN cord-304556-1f47gvys 60 12 on on IN cord-304556-1f47gvys 60 13 macrophages macrophage NNS cord-304556-1f47gvys 60 14 and and CC cord-304556-1f47gvys 60 15 even even RB cord-304556-1f47gvys 60 16 used use VBN cord-304556-1f47gvys 60 17 as as IN cord-304556-1f47gvys 60 18 a a DT cord-304556-1f47gvys 60 19 defining define VBG cord-304556-1f47gvys 60 20 marker marker NN cord-304556-1f47gvys 60 21 for for IN cord-304556-1f47gvys 60 22 them -PRON- PRP cord-304556-1f47gvys 60 23 . . . cord-304556-1f47gvys 61 1 Airway airway JJ cord-304556-1f47gvys 61 2 macrophages macrophage NNS cord-304556-1f47gvys 61 3 , , , cord-304556-1f47gvys 61 4 however however RB cord-304556-1f47gvys 61 5 , , , cord-304556-1f47gvys 61 6 unlike unlike IN cord-304556-1f47gvys 61 7 most most JJS cord-304556-1f47gvys 61 8 other other JJ cord-304556-1f47gvys 61 9 macrophages macrophage NNS cord-304556-1f47gvys 61 10 , , , cord-304556-1f47gvys 61 11 constitutively constitutively RB cord-304556-1f47gvys 61 12 express expres VBD cord-304556-1f47gvys 61 13 Axl Axl NNP cord-304556-1f47gvys 61 14 , , , cord-304556-1f47gvys 61 15 possibly possibly RB cord-304556-1f47gvys 61 16 due due IN cord-304556-1f47gvys 61 17 to to IN cord-304556-1f47gvys 61 18 the the DT cord-304556-1f47gvys 61 19 local local JJ cord-304556-1f47gvys 61 20 environment environment NN cord-304556-1f47gvys 61 21 that that WDT cord-304556-1f47gvys 61 22 is be VBZ cord-304556-1f47gvys 61 23 rich rich JJ cord-304556-1f47gvys 61 24 in in IN cord-304556-1f47gvys 61 25 granulocyte granulocyte NN cord-304556-1f47gvys 61 26 - - HYPH cord-304556-1f47gvys 61 27 macrophage macrophage NN cord-304556-1f47gvys 61 28 colony colony NN cord-304556-1f47gvys 61 29 - - HYPH cord-304556-1f47gvys 61 30 stimulating stimulate VBG cord-304556-1f47gvys 61 31 factor factor NN cord-304556-1f47gvys 61 32 ( ( -LRB- cord-304556-1f47gvys 61 33 GM GM NNP cord-304556-1f47gvys 61 34 - - HYPH cord-304556-1f47gvys 61 35 CSF CSF NNP cord-304556-1f47gvys 61 36 ) ) -RRB- cord-304556-1f47gvys 61 37 [ [ -LRB- cord-304556-1f47gvys 61 38 2 2 CD cord-304556-1f47gvys 61 39 ] ] -RRB- cord-304556-1f47gvys 61 40 . . . cord-304556-1f47gvys 62 1 Importantly importantly RB cord-304556-1f47gvys 62 2 , , , cord-304556-1f47gvys 62 3 receptors receptor NNS cord-304556-1f47gvys 62 4 that that WDT cord-304556-1f47gvys 62 5 recognise recognise VBP cord-304556-1f47gvys 62 6 apoptotic apoptotic JJ cord-304556-1f47gvys 62 7 cells cell NNS cord-304556-1f47gvys 62 8 can can MD cord-304556-1f47gvys 62 9 also also RB cord-304556-1f47gvys 62 10 play play VB cord-304556-1f47gvys 62 11 a a DT cord-304556-1f47gvys 62 12 dual dual JJ cord-304556-1f47gvys 62 13 function function NN cord-304556-1f47gvys 62 14 : : : cord-304556-1f47gvys 62 15 inducing induce VBG cord-304556-1f47gvys 62 16 the the DT cord-304556-1f47gvys 62 17 cytoskeletal cytoskeletal JJ cord-304556-1f47gvys 62 18 rearrangements rearrangement NNS cord-304556-1f47gvys 62 19 necessary necessary JJ cord-304556-1f47gvys 62 20 to to TO cord-304556-1f47gvys 62 21 ingest ingest VB cord-304556-1f47gvys 62 22 the the DT cord-304556-1f47gvys 62 23 apoptotic apoptotic JJ cord-304556-1f47gvys 62 24 cell cell NN cord-304556-1f47gvys 62 25 and and CC cord-304556-1f47gvys 62 26 also also RB cord-304556-1f47gvys 62 27 transmitting transmit VBG cord-304556-1f47gvys 62 28 an an DT cord-304556-1f47gvys 62 29 instructive instructive JJ cord-304556-1f47gvys 62 30 signal signal NN cord-304556-1f47gvys 62 31 [ [ -LRB- cord-304556-1f47gvys 62 32 45 45 CD cord-304556-1f47gvys 62 33 ] ] -RRB- cord-304556-1f47gvys 62 34 . . . cord-304556-1f47gvys 63 1 It -PRON- PRP cord-304556-1f47gvys 63 2 is be VBZ cord-304556-1f47gvys 63 3 interesting interesting JJ cord-304556-1f47gvys 63 4 to to TO cord-304556-1f47gvys 63 5 note note VB cord-304556-1f47gvys 63 6 that that IN cord-304556-1f47gvys 63 7 individual individual JJ cord-304556-1f47gvys 63 8 TAM TAM NNP cord-304556-1f47gvys 63 9 receptor receptor NN cord-304556-1f47gvys 63 10 family family NN cord-304556-1f47gvys 63 11 members member NNS cord-304556-1f47gvys 63 12 use use VBP cord-304556-1f47gvys 63 13 different different JJ cord-304556-1f47gvys 63 14 molecules molecule NNS cord-304556-1f47gvys 63 15 to to TO cord-304556-1f47gvys 63 16 bridge bridge VB cord-304556-1f47gvys 63 17 them -PRON- PRP cord-304556-1f47gvys 63 18 to to IN cord-304556-1f47gvys 63 19 PtdSer PtdSer NNP cord-304556-1f47gvys 63 20 externalised externalise VBN cord-304556-1f47gvys 63 21 on on IN cord-304556-1f47gvys 63 22 apoptotic apoptotic JJ cord-304556-1f47gvys 63 23 cells cell NNS cord-304556-1f47gvys 63 24 : : : cord-304556-1f47gvys 63 25 MerTK mertk NN cord-304556-1f47gvys 63 26 and and CC cord-304556-1f47gvys 63 27 Tyro3 Tyro3 NNP cord-304556-1f47gvys 63 28 are be VBP cord-304556-1f47gvys 63 29 activated activate VBN cord-304556-1f47gvys 63 30 by by IN cord-304556-1f47gvys 63 31 both both DT cord-304556-1f47gvys 63 32 Gas6 Gas6 NNP cord-304556-1f47gvys 63 33 and and CC cord-304556-1f47gvys 63 34 Protein Protein NNP cord-304556-1f47gvys 63 35 S S NNP cord-304556-1f47gvys 63 36 , , , cord-304556-1f47gvys 63 37 whereas whereas IN cord-304556-1f47gvys 63 38 the the DT cord-304556-1f47gvys 63 39 sole sole JJ cord-304556-1f47gvys 63 40 ligand ligand NN cord-304556-1f47gvys 63 41 for for IN cord-304556-1f47gvys 63 42 Axl Axl NNP cord-304556-1f47gvys 63 43 is be VBZ cord-304556-1f47gvys 63 44 Gas6 Gas6 NNP cord-304556-1f47gvys 63 45 [ [ -LRB- cord-304556-1f47gvys 63 46 46 46 CD cord-304556-1f47gvys 63 47 , , , cord-304556-1f47gvys 63 48 47 47 CD cord-304556-1f47gvys 63 49 ] ] -RRB- cord-304556-1f47gvys 63 50 . . . cord-304556-1f47gvys 64 1 In in IN cord-304556-1f47gvys 64 2 the the DT cord-304556-1f47gvys 64 3 case case NN cord-304556-1f47gvys 64 4 of of IN cord-304556-1f47gvys 64 5 MerTK mertk NN cord-304556-1f47gvys 64 6 and and CC cord-304556-1f47gvys 64 7 Tyro3 tyro3 NN cord-304556-1f47gvys 64 8 , , , cord-304556-1f47gvys 64 9 it -PRON- PRP cord-304556-1f47gvys 64 10 is be VBZ cord-304556-1f47gvys 64 11 therefore therefore RB cord-304556-1f47gvys 64 12 possible possible JJ cord-304556-1f47gvys 64 13 that that IN cord-304556-1f47gvys 64 14 specific specific JJ cord-304556-1f47gvys 64 15 signals signal NNS cord-304556-1f47gvys 64 16 triggered trigger VBN cord-304556-1f47gvys 64 17 by by IN cord-304556-1f47gvys 64 18 receptor receptor NN cord-304556-1f47gvys 64 19 ligation ligation NN cord-304556-1f47gvys 64 20 might may MD cord-304556-1f47gvys 64 21 differ differ VB cord-304556-1f47gvys 64 22 depending depend VBG cord-304556-1f47gvys 64 23 on on IN cord-304556-1f47gvys 64 24 the the DT cord-304556-1f47gvys 64 25 bridging bridging NN cord-304556-1f47gvys 64 26 molecule molecule NN cord-304556-1f47gvys 64 27 , , , cord-304556-1f47gvys 64 28 though though IN cord-304556-1f47gvys 64 29 this this DT cord-304556-1f47gvys 64 30 possibility possibility NN cord-304556-1f47gvys 64 31 remains remain VBZ cord-304556-1f47gvys 64 32 to to TO cord-304556-1f47gvys 64 33 be be VB cord-304556-1f47gvys 64 34 verified verify VBN cord-304556-1f47gvys 64 35 experimentally experimentally RB cord-304556-1f47gvys 64 36 . . . cord-304556-1f47gvys 65 1 Finally finally RB cord-304556-1f47gvys 65 2 , , , cord-304556-1f47gvys 65 3 further further JJ cord-304556-1f47gvys 65 4 selectivity selectivity NN cord-304556-1f47gvys 65 5 of of IN cord-304556-1f47gvys 65 6 response response NN cord-304556-1f47gvys 65 7 is be VBZ cord-304556-1f47gvys 65 8 afforded afford VBN cord-304556-1f47gvys 65 9 by by IN cord-304556-1f47gvys 65 10 co co NN cord-304556-1f47gvys 65 11 - - NN cord-304556-1f47gvys 65 12 operation operation NN cord-304556-1f47gvys 65 13 of of IN cord-304556-1f47gvys 65 14 multiple multiple JJ cord-304556-1f47gvys 65 15 receptors receptor NNS cord-304556-1f47gvys 65 16 such such JJ cord-304556-1f47gvys 65 17 as as IN cord-304556-1f47gvys 65 18 Axl Axl NNP cord-304556-1f47gvys 65 19 and and CC cord-304556-1f47gvys 65 20 LRP-1 LRP-1 NNP cord-304556-1f47gvys 65 21 on on IN cord-304556-1f47gvys 65 22 dendritic dendritic JJ cord-304556-1f47gvys 65 23 cells cell NNS cord-304556-1f47gvys 65 24 where where WRB cord-304556-1f47gvys 65 25 Axl Axl NNP cord-304556-1f47gvys 65 26 tethers tether VBZ cord-304556-1f47gvys 65 27 the the DT cord-304556-1f47gvys 65 28 apoptotic apoptotic JJ cord-304556-1f47gvys 65 29 cell cell NN cord-304556-1f47gvys 65 30 to to IN cord-304556-1f47gvys 65 31 dendritic dendritic JJ cord-304556-1f47gvys 65 32 cells cell NNS cord-304556-1f47gvys 65 33 , , , cord-304556-1f47gvys 65 34 but but CC cord-304556-1f47gvys 65 35 LRP-1 LRP-1 NNP cord-304556-1f47gvys 65 36 is be VBZ cord-304556-1f47gvys 65 37 required require VBN cord-304556-1f47gvys 65 38 to to TO cord-304556-1f47gvys 65 39 trigger trigger VB cord-304556-1f47gvys 65 40 internalisation internalisation NN cord-304556-1f47gvys 65 41 [ [ -LRB- cord-304556-1f47gvys 65 42 48 48 CD cord-304556-1f47gvys 65 43 ] ] -RRB- cord-304556-1f47gvys 65 44 . . . cord-304556-1f47gvys 66 1 The the DT cord-304556-1f47gvys 66 2 receptors receptor NNS cord-304556-1f47gvys 66 3 that that WDT cord-304556-1f47gvys 66 4 mediate mediate VBP cord-304556-1f47gvys 66 5 efferocytosis efferocytosis NN cord-304556-1f47gvys 66 6 often often RB cord-304556-1f47gvys 66 7 have have VBP cord-304556-1f47gvys 66 8 antiinflammatory antiinflammatory JJ cord-304556-1f47gvys 66 9 signalling signal VBG cord-304556-1f47gvys 66 10 consequences consequence NNS cord-304556-1f47gvys 66 11 that that WDT cord-304556-1f47gvys 66 12 can can MD cord-304556-1f47gvys 66 13 change change VB cord-304556-1f47gvys 66 14 the the DT cord-304556-1f47gvys 66 15 phenotype phenotype NN cord-304556-1f47gvys 66 16 and and CC cord-304556-1f47gvys 66 17 function function NN cord-304556-1f47gvys 66 18 of of IN cord-304556-1f47gvys 66 19 the the DT cord-304556-1f47gvys 66 20 ingesting ingest VBG cord-304556-1f47gvys 66 21 cell cell NN cord-304556-1f47gvys 66 22 . . . cord-304556-1f47gvys 67 1 For for IN cord-304556-1f47gvys 67 2 example example NN cord-304556-1f47gvys 67 3 , , , cord-304556-1f47gvys 67 4 engagement engagement NN cord-304556-1f47gvys 67 5 and and CC cord-304556-1f47gvys 67 6 activation activation NN cord-304556-1f47gvys 67 7 of of IN cord-304556-1f47gvys 67 8 TAM TAM NNP cord-304556-1f47gvys 67 9 receptors receptor NNS cord-304556-1f47gvys 67 10 inhibits inhibit VBZ cord-304556-1f47gvys 67 11 signalling signal VBG cord-304556-1f47gvys 67 12 pathways pathway NNS cord-304556-1f47gvys 67 13 triggered trigger VBN cord-304556-1f47gvys 67 14 by by IN cord-304556-1f47gvys 67 15 cytokines cytokine NNS cord-304556-1f47gvys 67 16 and and CC cord-304556-1f47gvys 67 17 toll toll NN cord-304556-1f47gvys 67 18 - - HYPH cord-304556-1f47gvys 67 19 like like JJ cord-304556-1f47gvys 67 20 receptor receptor NN cord-304556-1f47gvys 67 21 ligands ligand NNS cord-304556-1f47gvys 67 22 through through IN cord-304556-1f47gvys 67 23 induction induction NN cord-304556-1f47gvys 67 24 of of IN cord-304556-1f47gvys 67 25 suppressor suppressor NN cord-304556-1f47gvys 67 26 of of IN cord-304556-1f47gvys 67 27 cytokine cytokine NN cord-304556-1f47gvys 67 28 signalling-1 signalling-1 NNP cord-304556-1f47gvys 67 29 and and CC cord-304556-1f47gvys 67 30 3 3 CD cord-304556-1f47gvys 67 31 ( ( -LRB- cord-304556-1f47gvys 67 32 SOCS-1 SOCS-1 NNP cord-304556-1f47gvys 67 33 and and CC cord-304556-1f47gvys 67 34 3 3 CD cord-304556-1f47gvys 67 35 ) ) -RRB- cord-304556-1f47gvys 67 36 [ [ -LRB- cord-304556-1f47gvys 67 37 49 49 CD cord-304556-1f47gvys 67 38 , , , cord-304556-1f47gvys 67 39 50 50 CD cord-304556-1f47gvys 67 40 ] ] -RRB- cord-304556-1f47gvys 67 41 ( ( -LRB- cord-304556-1f47gvys 67 42 see see VB cord-304556-1f47gvys 67 43 Fig Fig NNP cord-304556-1f47gvys 67 44 . . . cord-304556-1f47gvys 68 1 1a 1a NN cord-304556-1f47gvys 68 2 , , , cord-304556-1f47gvys 68 3 b b LS cord-304556-1f47gvys 68 4 ) ) -RRB- cord-304556-1f47gvys 68 5 . . . cord-304556-1f47gvys 69 1 The the DT cord-304556-1f47gvys 69 2 impact impact NN cord-304556-1f47gvys 69 3 of of IN cord-304556-1f47gvys 69 4 apoptotic apoptotic JJ cord-304556-1f47gvys 69 5 cell cell NN cord-304556-1f47gvys 69 6 clearance clearance NN cord-304556-1f47gvys 69 7 on on IN cord-304556-1f47gvys 69 8 cell cell NN cord-304556-1f47gvys 69 9 function function NN cord-304556-1f47gvys 69 10 depends depend VBZ cord-304556-1f47gvys 69 11 on on IN cord-304556-1f47gvys 69 12 the the DT cord-304556-1f47gvys 69 13 cell cell NN cord-304556-1f47gvys 69 14 type type NN cord-304556-1f47gvys 69 15 mediating mediate VBG cord-304556-1f47gvys 69 16 efferocytosis efferocytosis NN cord-304556-1f47gvys 69 17 , , , cord-304556-1f47gvys 69 18 which which WDT cord-304556-1f47gvys 69 19 in in IN cord-304556-1f47gvys 69 20 turn turn NN cord-304556-1f47gvys 69 21 depends depend VBZ cord-304556-1f47gvys 69 22 on on IN cord-304556-1f47gvys 69 23 tissue tissue NN cord-304556-1f47gvys 69 24 location location NN cord-304556-1f47gvys 69 25 . . . cord-304556-1f47gvys 70 1 In in IN cord-304556-1f47gvys 70 2 the the DT cord-304556-1f47gvys 70 3 lung lung NN cord-304556-1f47gvys 70 4 , , , cord-304556-1f47gvys 70 5 efferocytosis efferocytosis NNP cord-304556-1f47gvys 70 6 is be VBZ cord-304556-1f47gvys 70 7 mediated mediate VBN cord-304556-1f47gvys 70 8 predominantly predominantly RB cord-304556-1f47gvys 70 9 by by IN cord-304556-1f47gvys 70 10 macrophages macrophage NNS cord-304556-1f47gvys 70 11 and and CC cord-304556-1f47gvys 70 12 airway airway NN cord-304556-1f47gvys 70 13 epithelial epithelial JJ cord-304556-1f47gvys 70 14 cells cell NNS cord-304556-1f47gvys 70 15 , , , cord-304556-1f47gvys 70 16 with with IN cord-304556-1f47gvys 70 17 most most JJS cord-304556-1f47gvys 70 18 consequences consequence NNS cord-304556-1f47gvys 70 19 studied study VBN cord-304556-1f47gvys 70 20 in in IN cord-304556-1f47gvys 70 21 the the DT cord-304556-1f47gvys 70 22 former former JJ cord-304556-1f47gvys 70 23 . . . cord-304556-1f47gvys 71 1 In in IN cord-304556-1f47gvys 71 2 macrophages macrophage NNS cord-304556-1f47gvys 71 3 , , , cord-304556-1f47gvys 71 4 efferocytosis efferocytosis NN cord-304556-1f47gvys 71 5 increases increase VBZ cord-304556-1f47gvys 71 6 the the DT cord-304556-1f47gvys 71 7 secretion secretion NN cord-304556-1f47gvys 71 8 of of IN cord-304556-1f47gvys 71 9 the the DT cord-304556-1f47gvys 71 10 antiinflammatory antiinflammatory JJ cord-304556-1f47gvys 71 11 cytokines cytokine NNS cord-304556-1f47gvys 71 12 , , , cord-304556-1f47gvys 71 13 transforming transform VBG cord-304556-1f47gvys 71 14 growth growth NN cord-304556-1f47gvys 71 15 factor factor NN cord-304556-1f47gvys 71 16 - - HYPH cord-304556-1f47gvys 71 17 β β NN cord-304556-1f47gvys 71 18 ( ( -LRB- cord-304556-1f47gvys 71 19 TGF TGF NNP cord-304556-1f47gvys 71 20 - - HYPH cord-304556-1f47gvys 71 21 β β NNP cord-304556-1f47gvys 71 22 ) ) -RRB- cord-304556-1f47gvys 71 23 and and CC cord-304556-1f47gvys 71 24 interleukin interleukin FW cord-304556-1f47gvys 71 25 ( ( -LRB- cord-304556-1f47gvys 72 1 IL)-10 IL)-10 NNP cord-304556-1f47gvys 72 2 [ [ -LRB- cord-304556-1f47gvys 72 3 51 51 CD cord-304556-1f47gvys 72 4 , , , cord-304556-1f47gvys 72 5 52 52 CD cord-304556-1f47gvys 72 6 ] ] -RRB- cord-304556-1f47gvys 72 7 , , , cord-304556-1f47gvys 72 8 while while IN cord-304556-1f47gvys 72 9 inhibiting inhibit VBG cord-304556-1f47gvys 72 10 secretion secretion NN cord-304556-1f47gvys 72 11 of of IN cord-304556-1f47gvys 72 12 proinflammatory proinflammatory JJ cord-304556-1f47gvys 72 13 mediators mediator NNS cord-304556-1f47gvys 72 14 such such JJ cord-304556-1f47gvys 72 15 as as IN cord-304556-1f47gvys 72 16 TNF TNF NNP cord-304556-1f47gvys 72 17 - - HYPH cord-304556-1f47gvys 72 18 α α NNP cord-304556-1f47gvys 72 19 , , , cord-304556-1f47gvys 72 20 IL-1 IL-1 NNP cord-304556-1f47gvys 72 21 , , , cord-304556-1f47gvys 72 22 IL-8 IL-8 NNP cord-304556-1f47gvys 72 23 and and CC cord-304556-1f47gvys 72 24 leukotriene leukotriene NN cord-304556-1f47gvys 72 25 C4 C4 NNP cord-304556-1f47gvys 72 26 [ [ -LRB- cord-304556-1f47gvys 72 27 53 53 CD cord-304556-1f47gvys 72 28 , , , cord-304556-1f47gvys 72 29 54 54 CD cord-304556-1f47gvys 72 30 ] ] -RRB- cord-304556-1f47gvys 72 31 . . . cord-304556-1f47gvys 73 1 IL-10 IL-10 NNP cord-304556-1f47gvys 73 2 production production NN cord-304556-1f47gvys 73 3 by by IN cord-304556-1f47gvys 73 4 macrophages macrophage NNS cord-304556-1f47gvys 73 5 upon upon IN cord-304556-1f47gvys 73 6 apoptotic apoptotic JJ cord-304556-1f47gvys 73 7 cell cell NN cord-304556-1f47gvys 73 8 contact contact NN cord-304556-1f47gvys 73 9 is be VBZ cord-304556-1f47gvys 73 10 , , , cord-304556-1f47gvys 73 11 in in IN cord-304556-1f47gvys 73 12 part part NN cord-304556-1f47gvys 73 13 , , , cord-304556-1f47gvys 73 14 dependent dependent JJ cord-304556-1f47gvys 73 15 upon upon IN cord-304556-1f47gvys 73 16 the the DT cord-304556-1f47gvys 73 17 scavenger scavenger NN cord-304556-1f47gvys 73 18 receptor receptor NN cord-304556-1f47gvys 73 19 CD36 CD36 NNP cord-304556-1f47gvys 73 20 [ [ -LRB- cord-304556-1f47gvys 73 21 51 51 CD cord-304556-1f47gvys 73 22 ] ] -RRB- cord-304556-1f47gvys 73 23 and and CC cord-304556-1f47gvys 73 24 TSP-1 TSP-1 NNP cord-304556-1f47gvys 73 25 , , , cord-304556-1f47gvys 73 26 which which WDT cord-304556-1f47gvys 73 27 links link VBZ cord-304556-1f47gvys 73 28 macrophages macrophage NNS cord-304556-1f47gvys 73 29 to to IN cord-304556-1f47gvys 73 30 apoptotic apoptotic JJ cord-304556-1f47gvys 73 31 cells cell NNS cord-304556-1f47gvys 73 32 in in IN cord-304556-1f47gvys 73 33 cooperation cooperation NN cord-304556-1f47gvys 73 34 with with IN cord-304556-1f47gvys 73 35 integrin integrin NN cord-304556-1f47gvys 73 36 αvβ3 αvβ3 XX cord-304556-1f47gvys 73 37 [ [ -LRB- cord-304556-1f47gvys 73 38 55 55 CD cord-304556-1f47gvys 73 39 ] ] -RRB- cord-304556-1f47gvys 73 40 . . . cord-304556-1f47gvys 74 1 Efferocytosis Efferocytosis NNP cord-304556-1f47gvys 74 2 also also RB cord-304556-1f47gvys 74 3 upregulates upregulate VBZ cord-304556-1f47gvys 74 4 prostaglandin prostaglandin NN cord-304556-1f47gvys 74 5 E2 e2 NN cord-304556-1f47gvys 74 6 ( ( -LRB- cord-304556-1f47gvys 74 7 PGE2 PGE2 NNP cord-304556-1f47gvys 74 8 ) ) -RRB- cord-304556-1f47gvys 74 9 and and CC cord-304556-1f47gvys 74 10 impairs impair VBZ cord-304556-1f47gvys 74 11 FcRmediated fcrmediated JJ cord-304556-1f47gvys 74 12 phagocytosis phagocytosis NN cord-304556-1f47gvys 74 13 [ [ -LRB- cord-304556-1f47gvys 74 14 54 54 CD cord-304556-1f47gvys 74 15 , , , cord-304556-1f47gvys 74 16 56 56 CD cord-304556-1f47gvys 74 17 ] ] -RRB- cord-304556-1f47gvys 74 18 , , , cord-304556-1f47gvys 74 19 and and CC cord-304556-1f47gvys 74 20 intratracheal intratracheal NN cord-304556-1f47gvys 74 21 instillation instillation NN cord-304556-1f47gvys 74 22 of of IN cord-304556-1f47gvys 74 23 apoptotic apoptotic JJ cord-304556-1f47gvys 74 24 cells cell NNS cord-304556-1f47gvys 74 25 enhances enhance VBZ cord-304556-1f47gvys 74 26 the the DT cord-304556-1f47gvys 74 27 resolution resolution NN cord-304556-1f47gvys 74 28 of of IN cord-304556-1f47gvys 74 29 LPSinduced lpsinduced JJ cord-304556-1f47gvys 74 30 acute acute JJ cord-304556-1f47gvys 74 31 pulmonary pulmonary JJ cord-304556-1f47gvys 74 32 inflammation inflammation NN cord-304556-1f47gvys 74 33 [ [ -LRB- cord-304556-1f47gvys 74 34 57 57 CD cord-304556-1f47gvys 74 35 ] ] -RRB- cord-304556-1f47gvys 74 36 . . . cord-304556-1f47gvys 75 1 This this DT cord-304556-1f47gvys 75 2 change change NN cord-304556-1f47gvys 75 3 in in IN cord-304556-1f47gvys 75 4 function function NN cord-304556-1f47gvys 75 5 from from IN cord-304556-1f47gvys 75 6 pro pro JJ cord-304556-1f47gvys 75 7 - - JJ cord-304556-1f47gvys 75 8 inflammatory inflammatory JJ cord-304556-1f47gvys 75 9 to to IN cord-304556-1f47gvys 75 10 pro pro JJ cord-304556-1f47gvys 75 11 - - JJ cord-304556-1f47gvys 75 12 resolution resolution NN cord-304556-1f47gvys 75 13 can can MD cord-304556-1f47gvys 75 14 be be VB cord-304556-1f47gvys 75 15 observed observe VBN cord-304556-1f47gvys 75 16 as as IN cord-304556-1f47gvys 75 17 a a DT cord-304556-1f47gvys 75 18 phenotypic phenotypic NN cord-304556-1f47gvys 75 19 switch switch NN cord-304556-1f47gvys 75 20 from from IN cord-304556-1f47gvys 75 21 an an DT cord-304556-1f47gvys 75 22 M1-to M1-to NNP cord-304556-1f47gvys 75 23 an an DT cord-304556-1f47gvys 75 24 M2-like M2-like NNP cord-304556-1f47gvys 75 25 macrophage macrophage NN cord-304556-1f47gvys 75 26 phenotype phenotype NN cord-304556-1f47gvys 75 27 and and CC cord-304556-1f47gvys 75 28 includes include VBZ cord-304556-1f47gvys 75 29 the the DT cord-304556-1f47gvys 75 30 induction induction NN cord-304556-1f47gvys 75 31 of of IN cord-304556-1f47gvys 75 32 peroxisome peroxisome NN cord-304556-1f47gvys 75 33 proliferator proliferator NN cord-304556-1f47gvys 75 34 - - HYPH cord-304556-1f47gvys 75 35 activated activate VBN cord-304556-1f47gvys 75 36 receptor receptor NN cord-304556-1f47gvys 75 37 - - HYPH cord-304556-1f47gvys 75 38 γ γ NN cord-304556-1f47gvys 75 39 ( ( -LRB- cord-304556-1f47gvys 75 40 PPARγ PPARγ NNS cord-304556-1f47gvys 75 41 ) ) -RRB- cord-304556-1f47gvys 75 42 [ [ -LRB- cord-304556-1f47gvys 75 43 58 58 CD cord-304556-1f47gvys 75 44 ] ] -RRB- cord-304556-1f47gvys 75 45 . . . cord-304556-1f47gvys 76 1 However however RB cord-304556-1f47gvys 76 2 , , , cord-304556-1f47gvys 76 3 this this DT cord-304556-1f47gvys 76 4 is be VBZ cord-304556-1f47gvys 76 5 likely likely JJ cord-304556-1f47gvys 76 6 to to TO cord-304556-1f47gvys 76 7 be be VB cord-304556-1f47gvys 76 8 context- context- JJ cord-304556-1f47gvys 76 9 , , , cord-304556-1f47gvys 76 10 cell cell NN cord-304556-1f47gvys 76 11 - - HYPH cord-304556-1f47gvys 76 12 type type NN cord-304556-1f47gvys 76 13 - - HYPH cord-304556-1f47gvys 76 14 and and CC cord-304556-1f47gvys 76 15 tissue tissue NN cord-304556-1f47gvys 76 16 - - HYPH cord-304556-1f47gvys 76 17 dependent dependent JJ cord-304556-1f47gvys 76 18 . . . cord-304556-1f47gvys 77 1 For for IN cord-304556-1f47gvys 77 2 example example NN cord-304556-1f47gvys 77 3 , , , cord-304556-1f47gvys 77 4 nitric nitric NN cord-304556-1f47gvys 77 5 oxide oxide NN cord-304556-1f47gvys 77 6 , , , cord-304556-1f47gvys 77 7 but but CC cord-304556-1f47gvys 77 8 not not RB cord-304556-1f47gvys 77 9 IL-10 IL-10 NNP cord-304556-1f47gvys 77 10 , , , cord-304556-1f47gvys 77 11 TGF TGF NNP cord-304556-1f47gvys 77 12 - - HYPH cord-304556-1f47gvys 77 13 β β NNP cord-304556-1f47gvys 77 14 or or CC cord-304556-1f47gvys 77 15 PGE2 PGE2 NNP cord-304556-1f47gvys 77 16 , , , cord-304556-1f47gvys 77 17 mediates mediate VBZ cord-304556-1f47gvys 77 18 the the DT cord-304556-1f47gvys 77 19 immunosuppressive immunosuppressive JJ cord-304556-1f47gvys 77 20 effects effect NNS cord-304556-1f47gvys 77 21 induced induce VBN cord-304556-1f47gvys 77 22 by by IN cord-304556-1f47gvys 77 23 apoptotic apoptotic JJ cord-304556-1f47gvys 77 24 cell cell NN cord-304556-1f47gvys 77 25 efferocytosis efferocytosis NN cord-304556-1f47gvys 77 26 in in IN cord-304556-1f47gvys 77 27 dendritic dendritic JJ cord-304556-1f47gvys 77 28 cells cell NNS cord-304556-1f47gvys 77 29 [ [ -LRB- cord-304556-1f47gvys 77 30 59 59 CD cord-304556-1f47gvys 77 31 ] ] -RRB- cord-304556-1f47gvys 77 32 . . . cord-304556-1f47gvys 78 1 It -PRON- PRP cord-304556-1f47gvys 78 2 is be VBZ cord-304556-1f47gvys 78 3 also also RB cord-304556-1f47gvys 78 4 interesting interesting JJ cord-304556-1f47gvys 78 5 to to TO cord-304556-1f47gvys 78 6 note note VB cord-304556-1f47gvys 78 7 that that IN cord-304556-1f47gvys 78 8 efferocytosis efferocytosis NN cord-304556-1f47gvys 78 9 by by IN cord-304556-1f47gvys 78 10 dendritic dendritic JJ cord-304556-1f47gvys 78 11 cells cell NNS cord-304556-1f47gvys 78 12 appears appear VBZ cord-304556-1f47gvys 78 13 to to TO cord-304556-1f47gvys 78 14 be be VB cord-304556-1f47gvys 78 15 subset subset VBN cord-304556-1f47gvys 78 16 - - HYPH cord-304556-1f47gvys 78 17 specific specific JJ cord-304556-1f47gvys 78 18 . . . cord-304556-1f47gvys 79 1 Only only RB cord-304556-1f47gvys 79 2 CD103 cd103 NN cord-304556-1f47gvys 79 3 + + CC cord-304556-1f47gvys 79 4 murine murine JJ cord-304556-1f47gvys 79 5 lung lung NN cord-304556-1f47gvys 79 6 dendritic dendritic NN cord-304556-1f47gvys 79 7 cells cell NNS cord-304556-1f47gvys 79 8 capture capture VBP cord-304556-1f47gvys 79 9 and and CC cord-304556-1f47gvys 79 10 present present JJ cord-304556-1f47gvys 79 11 apoptotic apoptotic JJ cord-304556-1f47gvys 79 12 cell cell NN cord-304556-1f47gvys 79 13 - - HYPH cord-304556-1f47gvys 79 14 associated associate VBN cord-304556-1f47gvys 79 15 antigen antigen NN cord-304556-1f47gvys 79 16 in in IN cord-304556-1f47gvys 79 17 health health NN cord-304556-1f47gvys 79 18 and and CC cord-304556-1f47gvys 79 19 disease disease NN cord-304556-1f47gvys 79 20 , , , cord-304556-1f47gvys 79 21 whereas whereas IN cord-304556-1f47gvys 79 22 both both DT cord-304556-1f47gvys 79 23 the the DT cord-304556-1f47gvys 79 24 CD11b CD11b NNPS cord-304556-1f47gvys 79 25 hi hi UH cord-304556-1f47gvys 79 26 and and CC cord-304556-1f47gvys 79 27 the the DT cord-304556-1f47gvys 79 28 CD103 cd103 NN cord-304556-1f47gvys 79 29 + + CD cord-304556-1f47gvys 79 30 dendritic dendritic JJ cord-304556-1f47gvys 79 31 cells cell NNS cord-304556-1f47gvys 79 32 ingest ingest VBP cord-304556-1f47gvys 79 33 and and CC cord-304556-1f47gvys 79 34 traffic traffic NN cord-304556-1f47gvys 79 35 latex latex NN cord-304556-1f47gvys 79 36 beads bead NNS cord-304556-1f47gvys 79 37 or or CC cord-304556-1f47gvys 79 38 soluble soluble JJ cord-304556-1f47gvys 79 39 antigen antigen NN cord-304556-1f47gvys 79 40 [ [ -LRB- cord-304556-1f47gvys 79 41 60 60 CD cord-304556-1f47gvys 79 42 ] ] -RRB- cord-304556-1f47gvys 79 43 . . . cord-304556-1f47gvys 80 1 Whether whether IN cord-304556-1f47gvys 80 2 this this DT cord-304556-1f47gvys 80 3 is be VBZ cord-304556-1f47gvys 80 4 due due JJ cord-304556-1f47gvys 80 5 to to IN cord-304556-1f47gvys 80 6 selective selective JJ cord-304556-1f47gvys 80 7 expression expression NN cord-304556-1f47gvys 80 8 of of IN cord-304556-1f47gvys 80 9 receptors receptor NNS cord-304556-1f47gvys 80 10 recognising recognise VBG cord-304556-1f47gvys 80 11 apoptotic apoptotic JJ cord-304556-1f47gvys 80 12 cells cell NNS cord-304556-1f47gvys 80 13 or or CC cord-304556-1f47gvys 80 14 a a DT cord-304556-1f47gvys 80 15 phenotypic phenotypic NN cord-304556-1f47gvys 80 16 switch switch NN cord-304556-1f47gvys 80 17 after after IN cord-304556-1f47gvys 80 18 ingestion ingestion NN cord-304556-1f47gvys 80 19 is be VBZ cord-304556-1f47gvys 80 20 not not RB cord-304556-1f47gvys 80 21 currently currently RB cord-304556-1f47gvys 80 22 known know VBN cord-304556-1f47gvys 80 23 . . . cord-304556-1f47gvys 81 1 Therefore therefore RB cord-304556-1f47gvys 81 2 , , , cord-304556-1f47gvys 81 3 clearance clearance NN cord-304556-1f47gvys 81 4 of of IN cord-304556-1f47gvys 81 5 apoptotic apoptotic JJ cord-304556-1f47gvys 81 6 cells cell NNS cord-304556-1f47gvys 81 7 has have VBZ cord-304556-1f47gvys 81 8 profound profound JJ cord-304556-1f47gvys 81 9 influences influence NNS cord-304556-1f47gvys 81 10 on on IN cord-304556-1f47gvys 81 11 the the DT cord-304556-1f47gvys 81 12 ingesting ingest VBG cord-304556-1f47gvys 81 13 cell cell NN cord-304556-1f47gvys 81 14 . . . cord-304556-1f47gvys 82 1 Though though IN cord-304556-1f47gvys 82 2 the the DT cord-304556-1f47gvys 82 3 outcome outcome NN cord-304556-1f47gvys 82 4 has have VBZ cord-304556-1f47gvys 82 5 predominantly predominantly RB cord-304556-1f47gvys 82 6 been be VBN cord-304556-1f47gvys 82 7 studied study VBN cord-304556-1f47gvys 82 8 for for IN cord-304556-1f47gvys 82 9 macrophages macrophage NNS cord-304556-1f47gvys 82 10 , , , cord-304556-1f47gvys 82 11 other other JJ cord-304556-1f47gvys 82 12 cell cell NN cord-304556-1f47gvys 82 13 types type NNS cord-304556-1f47gvys 82 14 , , , cord-304556-1f47gvys 82 15 particularly particularly RB cord-304556-1f47gvys 82 16 dendritic dendritic JJ cord-304556-1f47gvys 82 17 cells cell NNS cord-304556-1f47gvys 82 18 , , , cord-304556-1f47gvys 82 19 are be VBP cord-304556-1f47gvys 82 20 also also RB cord-304556-1f47gvys 82 21 likely likely JJ cord-304556-1f47gvys 82 22 to to TO cord-304556-1f47gvys 82 23 be be VB cord-304556-1f47gvys 82 24 affected affect VBN cord-304556-1f47gvys 82 25 . . . cord-304556-1f47gvys 83 1 [ [ -LRB- cord-304556-1f47gvys 83 2 19 19 CD cord-304556-1f47gvys 83 3 ] ] -RRB- cord-304556-1f47gvys 83 4 and and CC cord-304556-1f47gvys 83 5 humans human NNS cord-304556-1f47gvys 83 6 [ [ -LRB- cord-304556-1f47gvys 83 7 20 20 CD cord-304556-1f47gvys 83 8 ] ] -RRB- cord-304556-1f47gvys 83 9 Stabilin-2 Stabilin-2 NNP cord-304556-1f47gvys 84 1 Not not RB cord-304556-1f47gvys 84 2 studied study VBN cord-304556-1f47gvys 84 3 Integrin Integrin NNP cord-304556-1f47gvys 84 4 αvβ3 αvβ3 NN cord-304556-1f47gvys 84 5 or or CC cord-304556-1f47gvys 84 6 αvβ5 αvβ5 NN cord-304556-1f47gvys 84 7 through through IN cord-304556-1f47gvys 84 8 MFG MFG NNP cord-304556-1f47gvys 84 9 - - HYPH cord-304556-1f47gvys 84 10 E8 E8 NNP cord-304556-1f47gvys 84 11 Low Low NNP cord-304556-1f47gvys 84 12 αvβ3 αvβ3 NN cord-304556-1f47gvys 84 13 expression expression NN cord-304556-1f47gvys 84 14 in in IN cord-304556-1f47gvys 84 15 humans human NNS cord-304556-1f47gvys 84 16 [ [ -LRB- cord-304556-1f47gvys 84 17 21 21 CD cord-304556-1f47gvys 84 18 , , , cord-304556-1f47gvys 84 19 22 22 CD cord-304556-1f47gvys 84 20 ] ] -RRB- cord-304556-1f47gvys 84 21 _SP cord-304556-1f47gvys 85 1 Confirmed confirm VBN cord-304556-1f47gvys 85 2 in in IN cord-304556-1f47gvys 85 3 mice mouse NNS cord-304556-1f47gvys 85 4 [ [ -LRB- cord-304556-1f47gvys 85 5 23 23 CD cord-304556-1f47gvys 85 6 ] ] -RRB- cord-304556-1f47gvys 85 7 and and CC cord-304556-1f47gvys 85 8 humans human NNS cord-304556-1f47gvys 85 9 [ [ -LRB- cord-304556-1f47gvys 85 10 24 24 CD cord-304556-1f47gvys 85 11 ] ] -RRB- cord-304556-1f47gvys 86 1 TSP-1 tsp-1 IN cord-304556-1f47gvys 87 1 CD36 CD36 NNP cord-304556-1f47gvys 87 2 ( ( -LRB- cord-304556-1f47gvys 87 3 in in IN cord-304556-1f47gvys 87 4 complex complex NN cord-304556-1f47gvys 87 5 with with IN cord-304556-1f47gvys 87 6 integrin integrin NN cord-304556-1f47gvys 87 7 αvβ3 αvβ3 NN cord-304556-1f47gvys 87 8 or or CC cord-304556-1f47gvys 87 9 αvβ5 αvβ5 NN cord-304556-1f47gvys 87 10 ) ) -RRB- cord-304556-1f47gvys 88 1 Confirmed confirm VBN cord-304556-1f47gvys 88 2 in in IN cord-304556-1f47gvys 88 3 humans human NNS cord-304556-1f47gvys 88 4 [ [ -LRB- cord-304556-1f47gvys 88 5 21 21 CD cord-304556-1f47gvys 88 6 , , , cord-304556-1f47gvys 88 7 25 25 CD cord-304556-1f47gvys 88 8 ] ] -RRB- cord-304556-1f47gvys 88 9 _SP cord-304556-1f47gvys 88 10 Low low JJ cord-304556-1f47gvys 88 11 expression expression NN cord-304556-1f47gvys 88 12 in in IN cord-304556-1f47gvys 88 13 mice mouse NNS cord-304556-1f47gvys 88 14 [ [ -LRB- cord-304556-1f47gvys 88 15 26 26 CD cord-304556-1f47gvys 88 16 ] ] -RRB- cord-304556-1f47gvys 88 17 and and CC cord-304556-1f47gvys 88 18 humans human NNS cord-304556-1f47gvys 88 19 [ [ -LRB- cord-304556-1f47gvys 88 20 27 27 CD cord-304556-1f47gvys 88 21 ] ] -RRB- cord-304556-1f47gvys 89 1 Altered altered JJ cord-304556-1f47gvys 89 2 sugars sugar NNS cord-304556-1f47gvys 90 1 Lectin Lectin NNP cord-304556-1f47gvys 90 2 receptors receptor NNS cord-304556-1f47gvys 90 3 Mannose Mannose NNP cord-304556-1f47gvys 90 4 receptor receptor NN cord-304556-1f47gvys 90 5 confirmed confirm VBD cord-304556-1f47gvys 90 6 in in IN cord-304556-1f47gvys 90 7 mice mouse NNS cord-304556-1f47gvys 90 8 [ [ -LRB- cord-304556-1f47gvys 90 9 26 26 CD cord-304556-1f47gvys 90 10 ] ] -RRB- cord-304556-1f47gvys 90 11 and and CC cord-304556-1f47gvys 90 12 humans human NNS cord-304556-1f47gvys 90 13 [ [ -LRB- cord-304556-1f47gvys 90 14 28 28 CD cord-304556-1f47gvys 90 15 ] ] -RRB- cord-304556-1f47gvys 91 1 Calreticulin Calreticulin NNP cord-304556-1f47gvys 91 2 LRP-1 LRP-1 NNP cord-304556-1f47gvys 91 3 / / SYM cord-304556-1f47gvys 91 4 CD91 CD91 NNP cord-304556-1f47gvys 91 5 Confirmed confirm VBD cord-304556-1f47gvys 91 6 in in IN cord-304556-1f47gvys 91 7 mice mouse NNS cord-304556-1f47gvys 91 8 [ [ -LRB- cord-304556-1f47gvys 91 9 29 29 CD cord-304556-1f47gvys 91 10 ] ] -RRB- cord-304556-1f47gvys 91 11 and and CC cord-304556-1f47gvys 91 12 humans human NNS cord-304556-1f47gvys 91 13 [ [ -LRB- cord-304556-1f47gvys 91 14 22 22 CD cord-304556-1f47gvys 91 15 , , , cord-304556-1f47gvys 91 16 29 29 CD cord-304556-1f47gvys 91 17 ] ] -RRB- cord-304556-1f47gvys 92 1 C1q C1q NNP cord-304556-1f47gvys 92 2 SCARF1 SCARF1 NNP cord-304556-1f47gvys 93 1 Not not RB cord-304556-1f47gvys 93 2 studied study VBD cord-304556-1f47gvys 93 3 BAI1 BAI1 NNP cord-304556-1f47gvys 93 4 brain brain NN cord-304556-1f47gvys 93 5 - - HYPH cord-304556-1f47gvys 93 6 specific specific JJ cord-304556-1f47gvys 93 7 angiogenesis angiogenesis NN cord-304556-1f47gvys 93 8 inhibitor-1 inhibitor-1 NNP cord-304556-1f47gvys 93 9 , , , cord-304556-1f47gvys 94 1 ICAM3 ICAM3 VBN cord-304556-1f47gvys 95 1 intracellular intracellular JJ cord-304556-1f47gvys 95 2 adhesion adhesion NN cord-304556-1f47gvys 95 3 molecule-3 molecule-3 NNP cord-304556-1f47gvys 95 4 , , , cord-304556-1f47gvys 96 1 LRP-1 LRP-1 NNP cord-304556-1f47gvys 96 2 LDL LDL NNP cord-304556-1f47gvys 96 3 receptor receptor NN cord-304556-1f47gvys 96 4 - - HYPH cord-304556-1f47gvys 96 5 related relate VBN cord-304556-1f47gvys 96 6 protein-1 protein-1 NNP cord-304556-1f47gvys 96 7 , , , cord-304556-1f47gvys 96 8 MFG MFG NNP cord-304556-1f47gvys 96 9 - - HYPH cord-304556-1f47gvys 96 10 E8 E8 NNP cord-304556-1f47gvys 96 11 milk milk NN cord-304556-1f47gvys 96 12 fat fat NN cord-304556-1f47gvys 96 13 globule globule NN cord-304556-1f47gvys 96 14 - - HYPH cord-304556-1f47gvys 96 15 epidermal epidermal VBG cord-304556-1f47gvys 96 16 growth growth NN cord-304556-1f47gvys 96 17 factor factor NN cord-304556-1f47gvys 96 18 8 8 CD cord-304556-1f47gvys 96 19 , , , cord-304556-1f47gvys 96 20 PtdSer ptdser JJ cord-304556-1f47gvys 96 21 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 96 22 , , , cord-304556-1f47gvys 96 23 RAGE rage NN cord-304556-1f47gvys 96 24 receptor receptor NN cord-304556-1f47gvys 96 25 for for IN cord-304556-1f47gvys 96 26 advanced advanced JJ cord-304556-1f47gvys 96 27 glycation glycation NN cord-304556-1f47gvys 96 28 end end NN cord-304556-1f47gvys 96 29 products product NNS cord-304556-1f47gvys 96 30 , , , cord-304556-1f47gvys 96 31 TSP-1 TSP-1 NNP cord-304556-1f47gvys 96 32 thrombospondin-1 thrombospondin-1 NNP cord-304556-1f47gvys 96 33 , , , cord-304556-1f47gvys 96 34 SCARF1 SCARF1 NNP cord-304556-1f47gvys 96 35 scavenger scavenger NN cord-304556-1f47gvys 96 36 receptor receptor NN cord-304556-1f47gvys 96 37 class class NN cord-304556-1f47gvys 96 38 F f NN cord-304556-1f47gvys 96 39 , , , cord-304556-1f47gvys 96 40 member member NN cord-304556-1f47gvys 96 41 1 1 CD cord-304556-1f47gvys 96 42 , , , cord-304556-1f47gvys 96 43 TIM TIM NNP cord-304556-1f47gvys 96 44 T T NNP cord-304556-1f47gvys 96 45 cell cell NN cord-304556-1f47gvys 96 46 / / SYM cord-304556-1f47gvys 96 47 transmembrane transmembrane NN cord-304556-1f47gvys 96 48 , , , cord-304556-1f47gvys 96 49 immunoglobulin immunoglobulin NN cord-304556-1f47gvys 96 50 , , , cord-304556-1f47gvys 96 51 and and CC cord-304556-1f47gvys 96 52 mucin mucin NN cord-304556-1f47gvys 96 53 , , , cord-304556-1f47gvys 96 54 TREM2 TREM2 NNP cord-304556-1f47gvys 96 55 triggering trigger VBG cord-304556-1f47gvys 96 56 receptor receptor NN cord-304556-1f47gvys 96 57 expressed express VBN cord-304556-1f47gvys 96 58 on on IN cord-304556-1f47gvys 96 59 myeloid myeloid NN cord-304556-1f47gvys 96 60 cells-2 cells-2 NNP cord-304556-1f47gvys 97 1 In in IN cord-304556-1f47gvys 97 2 any any DT cord-304556-1f47gvys 97 3 tissue tissue NN cord-304556-1f47gvys 97 4 , , , cord-304556-1f47gvys 97 5 cell cell NN cord-304556-1f47gvys 97 6 turnover turnover NN cord-304556-1f47gvys 97 7 is be VBZ cord-304556-1f47gvys 97 8 a a DT cord-304556-1f47gvys 97 9 natural natural JJ cord-304556-1f47gvys 97 10 homeostatic homeostatic JJ cord-304556-1f47gvys 97 11 process process NN cord-304556-1f47gvys 97 12 and and CC cord-304556-1f47gvys 97 13 occurs occur VBZ cord-304556-1f47gvys 97 14 predominantly predominantly RB cord-304556-1f47gvys 97 15 by by IN cord-304556-1f47gvys 97 16 apoptosis apoptosis NN cord-304556-1f47gvys 97 17 before before IN cord-304556-1f47gvys 97 18 loss loss NN cord-304556-1f47gvys 97 19 of of IN cord-304556-1f47gvys 97 20 plasma plasma NN cord-304556-1f47gvys 97 21 membrane membrane NN cord-304556-1f47gvys 97 22 integrity integrity NN cord-304556-1f47gvys 97 23 . . . cord-304556-1f47gvys 98 1 Timely timely JJ cord-304556-1f47gvys 98 2 removal removal NN cord-304556-1f47gvys 98 3 of of IN cord-304556-1f47gvys 98 4 these these DT cord-304556-1f47gvys 98 5 apoptotic apoptotic JJ cord-304556-1f47gvys 98 6 cells cell NNS cord-304556-1f47gvys 98 7 is be VBZ cord-304556-1f47gvys 98 8 critical critical JJ cord-304556-1f47gvys 98 9 to to TO cord-304556-1f47gvys 98 10 prevent prevent VB cord-304556-1f47gvys 98 11 autoimmune autoimmune JJ cord-304556-1f47gvys 98 12 reactions reaction NNS cord-304556-1f47gvys 98 13 to to IN cord-304556-1f47gvys 98 14 cellular cellular JJ cord-304556-1f47gvys 98 15 constituents constituent NNS cord-304556-1f47gvys 98 16 . . . cord-304556-1f47gvys 99 1 However however RB cord-304556-1f47gvys 99 2 , , , cord-304556-1f47gvys 99 3 the the DT cord-304556-1f47gvys 99 4 speed speed NN cord-304556-1f47gvys 99 5 of of IN cord-304556-1f47gvys 99 6 turnover turnover NN cord-304556-1f47gvys 99 7 determines determine VBZ cord-304556-1f47gvys 99 8 the the DT cord-304556-1f47gvys 99 9 requirements requirement NNS cord-304556-1f47gvys 99 10 for for IN cord-304556-1f47gvys 99 11 the the DT cord-304556-1f47gvys 99 12 local local JJ cord-304556-1f47gvys 99 13 phagocytic phagocytic JJ cord-304556-1f47gvys 99 14 system system NN cord-304556-1f47gvys 99 15 in in IN cord-304556-1f47gvys 99 16 terms term NNS cord-304556-1f47gvys 99 17 of of IN cord-304556-1f47gvys 99 18 its -PRON- PRP$ cord-304556-1f47gvys 99 19 capacity capacity NN cord-304556-1f47gvys 99 20 to to TO cord-304556-1f47gvys 99 21 clear clear VB cord-304556-1f47gvys 99 22 the the DT cord-304556-1f47gvys 99 23 accumulating accumulate VBG cord-304556-1f47gvys 99 24 apoptotic apoptotic JJ cord-304556-1f47gvys 99 25 cells cell NNS cord-304556-1f47gvys 99 26 and and CC cord-304556-1f47gvys 99 27 is be VBZ cord-304556-1f47gvys 99 28 often often RB cord-304556-1f47gvys 99 29 governed govern VBN cord-304556-1f47gvys 99 30 by by IN cord-304556-1f47gvys 99 31 the the DT cord-304556-1f47gvys 99 32 local local JJ cord-304556-1f47gvys 99 33 microenvironment microenvironment NN cord-304556-1f47gvys 99 34 and and CC cord-304556-1f47gvys 99 35 past past JJ cord-304556-1f47gvys 99 36 inflammation inflammation NN cord-304556-1f47gvys 99 37 history history NN cord-304556-1f47gvys 99 38 . . . cord-304556-1f47gvys 100 1 In in IN cord-304556-1f47gvys 100 2 healthy healthy JJ cord-304556-1f47gvys 100 3 murine murine JJ cord-304556-1f47gvys 100 4 and and CC cord-304556-1f47gvys 100 5 human human JJ cord-304556-1f47gvys 100 6 lungs lung NNS cord-304556-1f47gvys 100 7 , , , cord-304556-1f47gvys 100 8 airway airway NN cord-304556-1f47gvys 100 9 macrophages macrophage NNS cord-304556-1f47gvys 100 10 make make VBP cord-304556-1f47gvys 100 11 up up RP cord-304556-1f47gvys 100 12 95 95 CD cord-304556-1f47gvys 100 13 % % NN cord-304556-1f47gvys 100 14 of of IN cord-304556-1f47gvys 100 15 cells cell NNS cord-304556-1f47gvys 100 16 retrieved retrieve VBN cord-304556-1f47gvys 100 17 by by IN cord-304556-1f47gvys 100 18 bronchoalveolar bronchoalveolar NNP cord-304556-1f47gvys 100 19 lavage lavage NNP cord-304556-1f47gvys 100 20 [ [ -LRB- cord-304556-1f47gvys 100 21 2 2 CD cord-304556-1f47gvys 100 22 , , , cord-304556-1f47gvys 100 23 61 61 CD cord-304556-1f47gvys 100 24 ] ] -RRB- cord-304556-1f47gvys 100 25 . . . cord-304556-1f47gvys 101 1 They -PRON- PRP cord-304556-1f47gvys 101 2 exist exist VBP cord-304556-1f47gvys 101 3 in in IN cord-304556-1f47gvys 101 4 a a DT cord-304556-1f47gvys 101 5 tolerant tolerant JJ cord-304556-1f47gvys 101 6 state state NN cord-304556-1f47gvys 101 7 due due JJ cord-304556-1f47gvys 101 8 to to IN cord-304556-1f47gvys 101 9 interaction interaction NN cord-304556-1f47gvys 101 10 with with IN cord-304556-1f47gvys 101 11 proteins protein NNS cord-304556-1f47gvys 101 12 and and CC cord-304556-1f47gvys 101 13 receptors receptor NNS cord-304556-1f47gvys 101 14 expressed express VBN cord-304556-1f47gvys 101 15 by by IN cord-304556-1f47gvys 101 16 or or CC cord-304556-1f47gvys 101 17 secreted secrete VBN cord-304556-1f47gvys 101 18 from from IN cord-304556-1f47gvys 101 19 the the DT cord-304556-1f47gvys 101 20 respiratory respiratory JJ cord-304556-1f47gvys 101 21 epithelium epithelium NN cord-304556-1f47gvys 101 22 . . . cord-304556-1f47gvys 102 1 Furthermore furthermore RB cord-304556-1f47gvys 102 2 , , , cord-304556-1f47gvys 102 3 mucus mucus NN cord-304556-1f47gvys 102 4 bathing bathe VBG cord-304556-1f47gvys 102 5 the the DT cord-304556-1f47gvys 102 6 epithelium epithelium NN cord-304556-1f47gvys 102 7 contains contain VBZ cord-304556-1f47gvys 102 8 surfactant surfactant NN cord-304556-1f47gvys 102 9 proteins protein NNS cord-304556-1f47gvys 102 10 that that WDT cord-304556-1f47gvys 102 11 dampen dampen VBP cord-304556-1f47gvys 102 12 macrophage macrophage NN cord-304556-1f47gvys 102 13 responsiveness responsiveness NN cord-304556-1f47gvys 102 14 in in IN cord-304556-1f47gvys 102 15 health health NN cord-304556-1f47gvys 102 16 [ [ -LRB- cord-304556-1f47gvys 102 17 62 62 CD cord-304556-1f47gvys 102 18 ] ] -RRB- cord-304556-1f47gvys 102 19 . . . cord-304556-1f47gvys 103 1 Chimeric chimeric JJ cord-304556-1f47gvys 103 2 mouse mouse NN cord-304556-1f47gvys 103 3 experiments experiment NNS cord-304556-1f47gvys 103 4 show show VBP cord-304556-1f47gvys 103 5 that that IN cord-304556-1f47gvys 103 6 resident resident JJ cord-304556-1f47gvys 103 7 airway airway NN cord-304556-1f47gvys 103 8 macrophages macrophage NNS cord-304556-1f47gvys 103 9 have have VBP cord-304556-1f47gvys 103 10 an an DT cord-304556-1f47gvys 103 11 unusually unusually RB cord-304556-1f47gvys 103 12 prolonged prolong VBN cord-304556-1f47gvys 103 13 life life NN cord-304556-1f47gvys 103 14 span span VBP cord-304556-1f47gvys 103 15 with with IN cord-304556-1f47gvys 103 16 negligible negligible JJ cord-304556-1f47gvys 103 17 turnover turnover NN cord-304556-1f47gvys 103 18 even even RB cord-304556-1f47gvys 103 19 at at IN cord-304556-1f47gvys 103 20 8 8 CD cord-304556-1f47gvys 103 21 months month NNS cord-304556-1f47gvys 103 22 in in IN cord-304556-1f47gvys 103 23 the the DT cord-304556-1f47gvys 103 24 absence absence NN cord-304556-1f47gvys 103 25 of of IN cord-304556-1f47gvys 103 26 inflammation inflammation NN cord-304556-1f47gvys 103 27 . . . cord-304556-1f47gvys 104 1 This this DT cord-304556-1f47gvys 104 2 situation situation NN cord-304556-1f47gvys 104 3 changes change VBZ cord-304556-1f47gvys 104 4 following follow VBG cord-304556-1f47gvys 104 5 their -PRON- PRP$ cord-304556-1f47gvys 104 6 depletion depletion NN cord-304556-1f47gvys 104 7 during during IN cord-304556-1f47gvys 104 8 inflammation inflammation NN cord-304556-1f47gvys 104 9 where where WRB cord-304556-1f47gvys 104 10 replenishment replenishment NN cord-304556-1f47gvys 104 11 from from IN cord-304556-1f47gvys 104 12 the the DT cord-304556-1f47gvys 104 13 periphery periphery NN cord-304556-1f47gvys 104 14 occurs occur VBZ cord-304556-1f47gvys 104 15 , , , cord-304556-1f47gvys 104 16 leading lead VBG cord-304556-1f47gvys 104 17 to to IN cord-304556-1f47gvys 104 18 a a DT cord-304556-1f47gvys 104 19 population population NN cord-304556-1f47gvys 104 20 of of IN cord-304556-1f47gvys 104 21 macrophages macrophage NNS cord-304556-1f47gvys 104 22 that that WDT cord-304556-1f47gvys 104 23 are be VBP cord-304556-1f47gvys 104 24 reported report VBN cord-304556-1f47gvys 104 25 to to TO cord-304556-1f47gvys 104 26 have have VB cord-304556-1f47gvys 104 27 a a DT cord-304556-1f47gvys 104 28 shorter short JJR cord-304556-1f47gvys 104 29 life life NN cord-304556-1f47gvys 104 30 span span NN cord-304556-1f47gvys 104 31 . . . cord-304556-1f47gvys 105 1 Airway airway NN cord-304556-1f47gvys 105 2 macrophage macrophage NN cord-304556-1f47gvys 105 3 removal removal NN cord-304556-1f47gvys 105 4 by by IN cord-304556-1f47gvys 105 5 irradiation irradiation NN cord-304556-1f47gvys 105 6 leads lead VBZ cord-304556-1f47gvys 105 7 to to IN cord-304556-1f47gvys 105 8 replenishment replenishment NN cord-304556-1f47gvys 105 9 from from IN cord-304556-1f47gvys 105 10 the the DT cord-304556-1f47gvys 105 11 periphery periphery NN cord-304556-1f47gvys 105 12 and and CC cord-304556-1f47gvys 105 13 a a DT cord-304556-1f47gvys 105 14 higher high JJR cord-304556-1f47gvys 105 15 turnover turnover NN cord-304556-1f47gvys 105 16 rate rate NN cord-304556-1f47gvys 105 17 of of IN cord-304556-1f47gvys 105 18 approximately approximately RB cord-304556-1f47gvys 105 19 30 30 CD cord-304556-1f47gvys 105 20 days day NNS cord-304556-1f47gvys 105 21 [ [ -LRB- cord-304556-1f47gvys 105 22 63 63 CD cord-304556-1f47gvys 105 23 ] ] -RRB- cord-304556-1f47gvys 105 24 . . . cord-304556-1f47gvys 106 1 However however RB cord-304556-1f47gvys 106 2 , , , cord-304556-1f47gvys 106 3 the the DT cord-304556-1f47gvys 106 4 fate fate NN cord-304556-1f47gvys 106 5 of of IN cord-304556-1f47gvys 106 6 resident resident JJ cord-304556-1f47gvys 106 7 airway airway NN cord-304556-1f47gvys 106 8 macrophages macrophage NNS cord-304556-1f47gvys 106 9 following follow VBG cord-304556-1f47gvys 106 10 pulmonary pulmonary JJ cord-304556-1f47gvys 106 11 infection infection NN cord-304556-1f47gvys 106 12 is be VBZ cord-304556-1f47gvys 106 13 not not RB cord-304556-1f47gvys 106 14 entirely entirely RB cord-304556-1f47gvys 106 15 clear clear JJ cord-304556-1f47gvys 106 16 . . . cord-304556-1f47gvys 107 1 One one CD cord-304556-1f47gvys 107 2 study study NN cord-304556-1f47gvys 107 3 shows show VBZ cord-304556-1f47gvys 107 4 that that IN cord-304556-1f47gvys 107 5 macrophages macrophage NNS cord-304556-1f47gvys 107 6 recruited recruit VBN cord-304556-1f47gvys 107 7 to to IN cord-304556-1f47gvys 107 8 the the DT cord-304556-1f47gvys 107 9 Fig Fig NNP cord-304556-1f47gvys 107 10 . . . cord-304556-1f47gvys 108 1 1 1 LS cord-304556-1f47gvys 109 1 The the DT cord-304556-1f47gvys 109 2 many many JJ cord-304556-1f47gvys 109 3 roles role NNS cord-304556-1f47gvys 109 4 of of IN cord-304556-1f47gvys 109 5 apoptotic apoptotic JJ cord-304556-1f47gvys 109 6 cell cell NN cord-304556-1f47gvys 109 7 recognition recognition NN cord-304556-1f47gvys 109 8 and and CC cord-304556-1f47gvys 109 9 phagocytosis phagocytosis NN cord-304556-1f47gvys 109 10 in in IN cord-304556-1f47gvys 109 11 immunity immunity NN cord-304556-1f47gvys 109 12 and and CC cord-304556-1f47gvys 109 13 infection infection NN cord-304556-1f47gvys 109 14 . . . cord-304556-1f47gvys 110 1 a a DT cord-304556-1f47gvys 110 2 Efferocytosis Efferocytosis NNP cord-304556-1f47gvys 110 3 leads lead VBZ cord-304556-1f47gvys 110 4 to to IN cord-304556-1f47gvys 110 5 removal removal NN cord-304556-1f47gvys 110 6 of of IN cord-304556-1f47gvys 110 7 apoptotic apoptotic JJ cord-304556-1f47gvys 110 8 cells cell NNS cord-304556-1f47gvys 110 9 without without IN cord-304556-1f47gvys 110 10 release release NN cord-304556-1f47gvys 110 11 of of IN cord-304556-1f47gvys 110 12 their -PRON- PRP$ cord-304556-1f47gvys 110 13 content content NN cord-304556-1f47gvys 110 14 . . . cord-304556-1f47gvys 111 1 When when WRB cord-304556-1f47gvys 111 2 apoptotic apoptotic JJ cord-304556-1f47gvys 111 3 cells cell NNS cord-304556-1f47gvys 111 4 are be VBP cord-304556-1f47gvys 111 5 not not RB cord-304556-1f47gvys 111 6 engulfed engulf VBN cord-304556-1f47gvys 111 7 in in IN cord-304556-1f47gvys 111 8 a a DT cord-304556-1f47gvys 111 9 timely timely JJ cord-304556-1f47gvys 111 10 manner manner NN cord-304556-1f47gvys 111 11 , , , cord-304556-1f47gvys 111 12 they -PRON- PRP cord-304556-1f47gvys 111 13 undergo undergo VBP cord-304556-1f47gvys 111 14 secondary secondary JJ cord-304556-1f47gvys 111 15 necrosis necrosis NN cord-304556-1f47gvys 111 16 and and CC cord-304556-1f47gvys 111 17 release release VB cord-304556-1f47gvys 111 18 necrotic necrotic JJ cord-304556-1f47gvys 111 19 cell cell NN cord-304556-1f47gvys 111 20 debris debris NN cord-304556-1f47gvys 111 21 which which WDT cord-304556-1f47gvys 111 22 subsequently subsequently RB cord-304556-1f47gvys 111 23 causes cause VBZ cord-304556-1f47gvys 111 24 uncontrolled uncontrolled JJ cord-304556-1f47gvys 111 25 inflammatory inflammatory JJ cord-304556-1f47gvys 111 26 activation activation NN cord-304556-1f47gvys 111 27 of of IN cord-304556-1f47gvys 111 28 the the DT cord-304556-1f47gvys 111 29 innate innate JJ cord-304556-1f47gvys 111 30 immune immune JJ cord-304556-1f47gvys 111 31 system system NN cord-304556-1f47gvys 111 32 by by IN cord-304556-1f47gvys 111 33 the the DT cord-304556-1f47gvys 111 34 released release VBN cord-304556-1f47gvys 111 35 ' ' POS cord-304556-1f47gvys 111 36 damage damage NN cord-304556-1f47gvys 111 37 associated associate VBD cord-304556-1f47gvys 111 38 molecular molecular JJ cord-304556-1f47gvys 111 39 patterns pattern NNS cord-304556-1f47gvys 111 40 ' ' '' cord-304556-1f47gvys 111 41 ( ( -LRB- cord-304556-1f47gvys 111 42 DAMPS damps NN cord-304556-1f47gvys 111 43 ) ) -RRB- cord-304556-1f47gvys 111 44 . . . cord-304556-1f47gvys 112 1 b b LS cord-304556-1f47gvys 112 2 During during IN cord-304556-1f47gvys 112 3 apoptosis apoptosis NN cord-304556-1f47gvys 112 4 , , , cord-304556-1f47gvys 112 5 cells cell NNS cord-304556-1f47gvys 112 6 expose expose VBP cord-304556-1f47gvys 112 7 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 112 8 ( ( -LRB- cord-304556-1f47gvys 112 9 PtdSer PtdSer NNP cord-304556-1f47gvys 112 10 ) ) -RRB- cord-304556-1f47gvys 112 11 on on IN cord-304556-1f47gvys 112 12 the the DT cord-304556-1f47gvys 112 13 outer outer JJ cord-304556-1f47gvys 112 14 leaflet leaflet NN cord-304556-1f47gvys 112 15 of of IN cord-304556-1f47gvys 112 16 their -PRON- PRP$ cord-304556-1f47gvys 112 17 membranes membrane NNS cord-304556-1f47gvys 112 18 , , , cord-304556-1f47gvys 112 19 which which WDT cord-304556-1f47gvys 112 20 is be VBZ cord-304556-1f47gvys 112 21 recognised recognise VBN cord-304556-1f47gvys 112 22 by by IN cord-304556-1f47gvys 112 23 specific specific JJ cord-304556-1f47gvys 112 24 receptors receptor NNS cord-304556-1f47gvys 112 25 expressed express VBN cord-304556-1f47gvys 112 26 on on IN cord-304556-1f47gvys 112 27 phagocytes phagocyte NNS cord-304556-1f47gvys 112 28 . . . cord-304556-1f47gvys 113 1 Recognition recognition NN cord-304556-1f47gvys 113 2 of of IN cord-304556-1f47gvys 113 3 PtdSer PtdSer NNP cord-304556-1f47gvys 113 4 by by IN cord-304556-1f47gvys 113 5 TAM TAM NNP cord-304556-1f47gvys 113 6 receptors receptor NNS cord-304556-1f47gvys 113 7 through through IN cord-304556-1f47gvys 113 8 bridging bridge VBG cord-304556-1f47gvys 113 9 molecules molecule NNS cord-304556-1f47gvys 114 1 Gas6 Gas6 NNP cord-304556-1f47gvys 114 2 and and CC cord-304556-1f47gvys 114 3 Protein Protein NNP cord-304556-1f47gvys 114 4 S S NNP cord-304556-1f47gvys 114 5 triggers trigger VBZ cord-304556-1f47gvys 114 6 a a DT cord-304556-1f47gvys 114 7 signalling signal VBG cord-304556-1f47gvys 114 8 cascade cascade NN cord-304556-1f47gvys 114 9 which which WDT cord-304556-1f47gvys 114 10 converges converge VBZ cord-304556-1f47gvys 114 11 on on IN cord-304556-1f47gvys 114 12 upregulation upregulation NN cord-304556-1f47gvys 114 13 of of IN cord-304556-1f47gvys 114 14 suppressor suppressor NN cord-304556-1f47gvys 114 15 of of IN cord-304556-1f47gvys 114 16 cytokine cytokine NN cord-304556-1f47gvys 114 17 signalling-1 signalling-1 NNP cord-304556-1f47gvys 114 18 and and CC cord-304556-1f47gvys 114 19 3 3 CD cord-304556-1f47gvys 114 20 ( ( -LRB- cord-304556-1f47gvys 114 21 SOCS3 SOCS3 NNP cord-304556-1f47gvys 114 22 ) ) -RRB- cord-304556-1f47gvys 114 23 , , , cord-304556-1f47gvys 114 24 which which WDT cord-304556-1f47gvys 114 25 act act VBP cord-304556-1f47gvys 114 26 as as IN cord-304556-1f47gvys 114 27 negative negative JJ cord-304556-1f47gvys 114 28 regulators regulator NNS cord-304556-1f47gvys 114 29 of of IN cord-304556-1f47gvys 114 30 the the DT cord-304556-1f47gvys 114 31 immune immune JJ cord-304556-1f47gvys 114 32 response response NN cord-304556-1f47gvys 114 33 . . . cord-304556-1f47gvys 115 1 Activation activation NN cord-304556-1f47gvys 115 2 of of IN cord-304556-1f47gvys 115 3 TAM TAM NNP cord-304556-1f47gvys 115 4 receptors receptor NNS cord-304556-1f47gvys 115 5 by by IN cord-304556-1f47gvys 115 6 apoptotic apoptotic JJ cord-304556-1f47gvys 115 7 cells cell NNS cord-304556-1f47gvys 115 8 inhibits inhibit VBZ cord-304556-1f47gvys 115 9 production production NN cord-304556-1f47gvys 115 10 of of IN cord-304556-1f47gvys 115 11 proinflammatory proinflammatory JJ cord-304556-1f47gvys 115 12 cytokines cytokine NNS cord-304556-1f47gvys 115 13 , , , cord-304556-1f47gvys 115 14 such such JJ cord-304556-1f47gvys 115 15 as as IN cord-304556-1f47gvys 115 16 TNFα TNFα NNS cord-304556-1f47gvys 115 17 and and CC cord-304556-1f47gvys 115 18 IL-6 IL-6 NNP cord-304556-1f47gvys 115 19 , , , cord-304556-1f47gvys 115 20 while while IN cord-304556-1f47gvys 115 21 promoting promote VBG cord-304556-1f47gvys 115 22 expression expression NN cord-304556-1f47gvys 115 23 of of IN cord-304556-1f47gvys 115 24 factors factor NNS cord-304556-1f47gvys 115 25 that that WDT cord-304556-1f47gvys 115 26 suppress suppress VBP cord-304556-1f47gvys 115 27 inflammation inflammation NN cord-304556-1f47gvys 115 28 and and CC cord-304556-1f47gvys 115 29 promote promote VB cord-304556-1f47gvys 115 30 tissue tissue NN cord-304556-1f47gvys 115 31 repair repair NN cord-304556-1f47gvys 115 32 , , , cord-304556-1f47gvys 115 33 including include VBG cord-304556-1f47gvys 115 34 IL-10 IL-10 NNP cord-304556-1f47gvys 115 35 and and CC cord-304556-1f47gvys 115 36 TGF TGF NNP cord-304556-1f47gvys 115 37 - - HYPH cord-304556-1f47gvys 115 38 β β NNP cord-304556-1f47gvys 115 39 . . . cord-304556-1f47gvys 116 1 c c LS cord-304556-1f47gvys 116 2 Some some DT cord-304556-1f47gvys 116 3 enveloped envelop VBD cord-304556-1f47gvys 116 4 viruses virus NNS cord-304556-1f47gvys 116 5 express express VBP cord-304556-1f47gvys 116 6 PtdSer PtdSer NNP cord-304556-1f47gvys 116 7 on on IN cord-304556-1f47gvys 116 8 their -PRON- PRP$ cord-304556-1f47gvys 116 9 envelopes envelope NNS cord-304556-1f47gvys 116 10 and and CC cord-304556-1f47gvys 116 11 use use VB cord-304556-1f47gvys 116 12 PtdSer PtdSer NNP cord-304556-1f47gvys 116 13 recognition recognition NN cord-304556-1f47gvys 116 14 receptors receptor NNS cord-304556-1f47gvys 116 15 , , , cord-304556-1f47gvys 116 16 such such JJ cord-304556-1f47gvys 116 17 as as IN cord-304556-1f47gvys 116 18 TAM TAM NNP cord-304556-1f47gvys 116 19 and and CC cord-304556-1f47gvys 116 20 TIM TIM NNP cord-304556-1f47gvys 116 21 receptor receptor NN cord-304556-1f47gvys 116 22 families family NNS cord-304556-1f47gvys 116 23 , , , cord-304556-1f47gvys 116 24 to to TO cord-304556-1f47gvys 116 25 promote promote VB cord-304556-1f47gvys 116 26 infection infection NN cord-304556-1f47gvys 116 27 of of IN cord-304556-1f47gvys 116 28 the the DT cord-304556-1f47gvys 116 29 host host NN cord-304556-1f47gvys 116 30 cells cell NNS cord-304556-1f47gvys 116 31 and and CC cord-304556-1f47gvys 116 32 evade evade VB cord-304556-1f47gvys 116 33 the the DT cord-304556-1f47gvys 116 34 immune immune JJ cord-304556-1f47gvys 116 35 response response NN cord-304556-1f47gvys 116 36 . . . cord-304556-1f47gvys 117 1 d d NNP cord-304556-1f47gvys 117 2 During during IN cord-304556-1f47gvys 117 3 microbial microbial JJ cord-304556-1f47gvys 117 4 infections infection NNS cord-304556-1f47gvys 117 5 with with IN cord-304556-1f47gvys 117 6 intracellular intracellular JJ cord-304556-1f47gvys 117 7 pathogens pathogen NNS cord-304556-1f47gvys 117 8 , , , cord-304556-1f47gvys 117 9 induction induction NN cord-304556-1f47gvys 117 10 of of IN cord-304556-1f47gvys 117 11 apoptosis apoptosis NN cord-304556-1f47gvys 117 12 of of IN cord-304556-1f47gvys 117 13 infected infected JJ cord-304556-1f47gvys 117 14 cells cell NNS cord-304556-1f47gvys 117 15 is be VBZ cord-304556-1f47gvys 117 16 one one CD cord-304556-1f47gvys 117 17 of of IN cord-304556-1f47gvys 117 18 the the DT cord-304556-1f47gvys 117 19 strategies strategy NNS cord-304556-1f47gvys 117 20 of of IN cord-304556-1f47gvys 117 21 the the DT cord-304556-1f47gvys 117 22 host host NN cord-304556-1f47gvys 117 23 immune immune JJ cord-304556-1f47gvys 117 24 system system NN cord-304556-1f47gvys 117 25 to to TO cord-304556-1f47gvys 117 26 facilitate facilitate VB cord-304556-1f47gvys 117 27 pathogen pathogen NN cord-304556-1f47gvys 117 28 clearance clearance NN cord-304556-1f47gvys 117 29 . . . cord-304556-1f47gvys 118 1 For for IN cord-304556-1f47gvys 118 2 example example NN cord-304556-1f47gvys 118 3 , , , cord-304556-1f47gvys 118 4 in in IN cord-304556-1f47gvys 118 5 case case NN cord-304556-1f47gvys 118 6 of of IN cord-304556-1f47gvys 118 7 Mycobacterium Mycobacterium NNP cord-304556-1f47gvys 118 8 tuberculosis tuberculosis NN cord-304556-1f47gvys 118 9 ( ( -LRB- cord-304556-1f47gvys 118 10 Mtb Mtb NNP cord-304556-1f47gvys 118 11 ) ) -RRB- cord-304556-1f47gvys 118 12 infections infection NNS cord-304556-1f47gvys 118 13 , , , cord-304556-1f47gvys 118 14 necrosis necrosis NN cord-304556-1f47gvys 118 15 of of IN cord-304556-1f47gvys 118 16 infected infected JJ cord-304556-1f47gvys 118 17 cells cell NNS cord-304556-1f47gvys 118 18 leads lead VBZ cord-304556-1f47gvys 118 19 to to IN cord-304556-1f47gvys 118 20 dissemination dissemination NN cord-304556-1f47gvys 118 21 of of IN cord-304556-1f47gvys 118 22 bacteria bacteria NNS cord-304556-1f47gvys 118 23 , , , cord-304556-1f47gvys 118 24 whereas whereas IN cord-304556-1f47gvys 118 25 engulfment engulfment NN cord-304556-1f47gvys 118 26 of of IN cord-304556-1f47gvys 118 27 infected infected JJ cord-304556-1f47gvys 118 28 cells cell NNS cord-304556-1f47gvys 118 29 undergoing undergo VBG cord-304556-1f47gvys 118 30 apoptosis apoptosis NN cord-304556-1f47gvys 118 31 allows allow VBZ cord-304556-1f47gvys 118 32 for for IN cord-304556-1f47gvys 118 33 pathogen pathogen NN cord-304556-1f47gvys 118 34 destruction destruction NN cord-304556-1f47gvys 118 35 airways airway NNS cord-304556-1f47gvys 118 36 from from IN cord-304556-1f47gvys 118 37 the the DT cord-304556-1f47gvys 118 38 periphery periphery NN cord-304556-1f47gvys 118 39 during during IN cord-304556-1f47gvys 118 40 influenza influenza JJ cord-304556-1f47gvys 118 41 infection infection NN cord-304556-1f47gvys 118 42 contract contract NN cord-304556-1f47gvys 118 43 by by IN cord-304556-1f47gvys 118 44 Fas Fas NNP cord-304556-1f47gvys 118 45 - - HYPH cord-304556-1f47gvys 118 46 dependent dependent JJ cord-304556-1f47gvys 118 47 apoptosis apoptosis NN cord-304556-1f47gvys 118 48 , , , cord-304556-1f47gvys 118 49 while while IN cord-304556-1f47gvys 118 50 the the DT cord-304556-1f47gvys 118 51 number number NN cord-304556-1f47gvys 118 52 of of IN cord-304556-1f47gvys 118 53 resident resident JJ cord-304556-1f47gvys 118 54 airway airway NN cord-304556-1f47gvys 118 55 macrophages macrophage NNS cord-304556-1f47gvys 118 56 remains remain VBZ cord-304556-1f47gvys 118 57 unchanged unchanged JJ cord-304556-1f47gvys 118 58 [ [ -LRB- cord-304556-1f47gvys 118 59 64 64 CD cord-304556-1f47gvys 118 60 ] ] -RRB- cord-304556-1f47gvys 118 61 , , , cord-304556-1f47gvys 118 62 whereas whereas IN cord-304556-1f47gvys 118 63 another another DT cord-304556-1f47gvys 118 64 implies imply VBZ cord-304556-1f47gvys 118 65 significant significant JJ cord-304556-1f47gvys 118 66 ablation ablation NN cord-304556-1f47gvys 118 67 of of IN cord-304556-1f47gvys 118 68 resident resident JJ cord-304556-1f47gvys 118 69 airway airway NN cord-304556-1f47gvys 118 70 macrophages macrophage NNS cord-304556-1f47gvys 118 71 followed follow VBN cord-304556-1f47gvys 118 72 by by IN cord-304556-1f47gvys 118 73 replenishment replenishment NN cord-304556-1f47gvys 118 74 from from IN cord-304556-1f47gvys 118 75 the the DT cord-304556-1f47gvys 118 76 interstitial interstitial JJ cord-304556-1f47gvys 118 77 pool pool NN cord-304556-1f47gvys 118 78 [ [ -LRB- cord-304556-1f47gvys 118 79 65 65 CD cord-304556-1f47gvys 118 80 ] ] -RRB- cord-304556-1f47gvys 118 81 . . . cord-304556-1f47gvys 119 1 Discrepancy discrepancy NN cord-304556-1f47gvys 119 2 might may MD cord-304556-1f47gvys 119 3 arise arise VB cord-304556-1f47gvys 119 4 from from IN cord-304556-1f47gvys 119 5 the the DT cord-304556-1f47gvys 119 6 use use NN cord-304556-1f47gvys 119 7 of of IN cord-304556-1f47gvys 119 8 intranasal intranasal NN cord-304556-1f47gvys 119 9 dye dye NN cord-304556-1f47gvys 119 10 ( ( -LRB- cord-304556-1f47gvys 119 11 that that WDT cord-304556-1f47gvys 119 12 becomes become VBZ cord-304556-1f47gvys 119 13 diluted dilute VBN cord-304556-1f47gvys 119 14 on on IN cord-304556-1f47gvys 119 15 cell cell NN cord-304556-1f47gvys 119 16 division division NN cord-304556-1f47gvys 119 17 ) ) -RRB- cord-304556-1f47gvys 119 18 or or CC cord-304556-1f47gvys 119 19 the the DT cord-304556-1f47gvys 119 20 depletion depletion NN cord-304556-1f47gvys 119 21 by by IN cord-304556-1f47gvys 119 22 irradiation irradiation NN cord-304556-1f47gvys 119 23 with with IN cord-304556-1f47gvys 119 24 the the DT cord-304556-1f47gvys 119 25 lung lung NN cord-304556-1f47gvys 119 26 protected protect VBN cord-304556-1f47gvys 119 27 by by IN cord-304556-1f47gvys 119 28 lead lead NN cord-304556-1f47gvys 119 29 . . . cord-304556-1f47gvys 120 1 In in IN cord-304556-1f47gvys 120 2 order order NN cord-304556-1f47gvys 120 3 to to TO cord-304556-1f47gvys 120 4 track track VB cord-304556-1f47gvys 120 5 definitively definitively RB cord-304556-1f47gvys 120 6 the the DT cord-304556-1f47gvys 120 7 fate fate NN cord-304556-1f47gvys 120 8 of of IN cord-304556-1f47gvys 120 9 airway airway NN cord-304556-1f47gvys 120 10 macrophages macrophage NNS cord-304556-1f47gvys 120 11 following follow VBG cord-304556-1f47gvys 120 12 influenza influenza NN cord-304556-1f47gvys 120 13 infection infection NN cord-304556-1f47gvys 120 14 , , , cord-304556-1f47gvys 120 15 the the DT cord-304556-1f47gvys 120 16 Flt3-Cre Flt3-Cre NNP cord-304556-1f47gvys 120 17 × × NN cord-304556-1f47gvys 120 18 Rosa26-LSL Rosa26-LSL NNP cord-304556-1f47gvys 120 19 - - HYPH cord-304556-1f47gvys 120 20 YFP YFP NNP cord-304556-1f47gvys 120 21 reporter reporter NN cord-304556-1f47gvys 120 22 mice mouse NNS cord-304556-1f47gvys 120 23 would would MD cord-304556-1f47gvys 120 24 be be VB cord-304556-1f47gvys 120 25 useful useful JJ cord-304556-1f47gvys 120 26 as as IN cord-304556-1f47gvys 120 27 all all DT cord-304556-1f47gvys 120 28 bone bone NN cord-304556-1f47gvys 120 29 marrow marrow NN cord-304556-1f47gvys 120 30 emigrants emigrant NNS cord-304556-1f47gvys 120 31 become become VBP cord-304556-1f47gvys 120 32 YFP YFP NNP cord-304556-1f47gvys 120 33 expressing express VBG cord-304556-1f47gvys 120 34 and and CC cord-304556-1f47gvys 120 35 so so RB cord-304556-1f47gvys 120 36 mice mouse NNS cord-304556-1f47gvys 120 37 do do VBP cord-304556-1f47gvys 120 38 not not RB cord-304556-1f47gvys 120 39 require require VB cord-304556-1f47gvys 120 40 prior prior JJ cord-304556-1f47gvys 120 41 manipulation manipulation NN cord-304556-1f47gvys 120 42 to to TO cord-304556-1f47gvys 120 43 distinguish distinguish VB cord-304556-1f47gvys 120 44 resident resident NN cord-304556-1f47gvys 120 45 versus versus IN cord-304556-1f47gvys 120 46 recruited recruit VBN cord-304556-1f47gvys 120 47 airway airway NN cord-304556-1f47gvys 120 48 cells cell NNS cord-304556-1f47gvys 120 49 [ [ -LRB- cord-304556-1f47gvys 120 50 66 66 CD cord-304556-1f47gvys 120 51 ] ] -RRB- cord-304556-1f47gvys 120 52 . . . cord-304556-1f47gvys 121 1 Like like IN cord-304556-1f47gvys 121 2 airway airway NN cord-304556-1f47gvys 121 3 macrophages macrophage NNS cord-304556-1f47gvys 121 4 , , , cord-304556-1f47gvys 121 5 epithelial epithelial JJ cord-304556-1f47gvys 121 6 cells cell NNS cord-304556-1f47gvys 121 7 similarly similarly RB cord-304556-1f47gvys 121 8 have have VBP cord-304556-1f47gvys 121 9 a a DT cord-304556-1f47gvys 121 10 long long JJ cord-304556-1f47gvys 121 11 half half JJ cord-304556-1f47gvys 121 12 - - HYPH cord-304556-1f47gvys 121 13 life life NN cord-304556-1f47gvys 121 14 in in IN cord-304556-1f47gvys 121 15 health health NN cord-304556-1f47gvys 121 16 . . . cord-304556-1f47gvys 122 1 Using use VBG cord-304556-1f47gvys 122 2 reporter reporter NN cord-304556-1f47gvys 122 3 mice mouse NNS cord-304556-1f47gvys 122 4 where where WRB cord-304556-1f47gvys 122 5 ciliated ciliated JJ cord-304556-1f47gvys 122 6 cells cell NNS cord-304556-1f47gvys 122 7 and and CC cord-304556-1f47gvys 122 8 their -PRON- PRP$ cord-304556-1f47gvys 122 9 progeny progeny NN cord-304556-1f47gvys 122 10 can can MD cord-304556-1f47gvys 122 11 be be VB cord-304556-1f47gvys 122 12 tracked track VBN cord-304556-1f47gvys 122 13 across across IN cord-304556-1f47gvys 122 14 their -PRON- PRP$ cord-304556-1f47gvys 122 15 lifetime lifetime NN cord-304556-1f47gvys 122 16 , , , cord-304556-1f47gvys 122 17 a a DT cord-304556-1f47gvys 122 18 half half JJ cord-304556-1f47gvys 122 19 - - HYPH cord-304556-1f47gvys 122 20 life life NN cord-304556-1f47gvys 122 21 of of IN cord-304556-1f47gvys 122 22 6 6 CD cord-304556-1f47gvys 122 23 months month NNS cord-304556-1f47gvys 122 24 in in IN cord-304556-1f47gvys 122 25 the the DT cord-304556-1f47gvys 122 26 trachea trachea NN cord-304556-1f47gvys 122 27 and and CC cord-304556-1f47gvys 122 28 17 17 CD cord-304556-1f47gvys 122 29 months month NNS cord-304556-1f47gvys 122 30 in in IN cord-304556-1f47gvys 122 31 the the DT cord-304556-1f47gvys 122 32 bronchioles bronchiole NNS cord-304556-1f47gvys 122 33 and and CC cord-304556-1f47gvys 122 34 terminal terminal JJ cord-304556-1f47gvys 122 35 bronchioles bronchiole NNS cord-304556-1f47gvys 122 36 has have VBZ cord-304556-1f47gvys 122 37 been be VBN cord-304556-1f47gvys 122 38 estimated estimate VBN cord-304556-1f47gvys 122 39 [ [ -LRB- cord-304556-1f47gvys 122 40 67 67 CD cord-304556-1f47gvys 122 41 ] ] -RRB- cord-304556-1f47gvys 122 42 . . . cord-304556-1f47gvys 123 1 Taken take VBN cord-304556-1f47gvys 123 2 together together RB cord-304556-1f47gvys 123 3 , , , cord-304556-1f47gvys 123 4 these these DT cord-304556-1f47gvys 123 5 observations observation NNS cord-304556-1f47gvys 123 6 indicate indicate VBP cord-304556-1f47gvys 123 7 that that IN cord-304556-1f47gvys 123 8 in in IN cord-304556-1f47gvys 123 9 homeostasis homeostasis NN cord-304556-1f47gvys 123 10 relatively relatively RB cord-304556-1f47gvys 123 11 small small JJ cord-304556-1f47gvys 123 12 quantities quantity NNS cord-304556-1f47gvys 123 13 of of IN cord-304556-1f47gvys 123 14 apoptotic apoptotic JJ cord-304556-1f47gvys 123 15 cells cell NNS cord-304556-1f47gvys 123 16 appear appear VBP cord-304556-1f47gvys 123 17 in in IN cord-304556-1f47gvys 123 18 the the DT cord-304556-1f47gvys 123 19 airways airway NNS cord-304556-1f47gvys 123 20 due due JJ cord-304556-1f47gvys 123 21 to to IN cord-304556-1f47gvys 123 22 slow slow JJ cord-304556-1f47gvys 123 23 turnover turnover NN cord-304556-1f47gvys 123 24 of of IN cord-304556-1f47gvys 123 25 the the DT cord-304556-1f47gvys 123 26 main main JJ cord-304556-1f47gvys 123 27 cell cell NN cord-304556-1f47gvys 123 28 populations population NNS cord-304556-1f47gvys 123 29 residing reside VBG cord-304556-1f47gvys 123 30 in in IN cord-304556-1f47gvys 123 31 the the DT cord-304556-1f47gvys 123 32 healthy healthy JJ cord-304556-1f47gvys 123 33 lung lung NN cord-304556-1f47gvys 123 34 . . . cord-304556-1f47gvys 124 1 It -PRON- PRP cord-304556-1f47gvys 124 2 is be VBZ cord-304556-1f47gvys 124 3 therefore therefore RB cord-304556-1f47gvys 124 4 not not RB cord-304556-1f47gvys 124 5 surprising surprising JJ cord-304556-1f47gvys 124 6 that that IN cord-304556-1f47gvys 124 7 lung lung NN cord-304556-1f47gvys 124 8 phagocytes phagocyte NNS cord-304556-1f47gvys 124 9 efficiently efficiently RB cord-304556-1f47gvys 124 10 clear clear VBP cord-304556-1f47gvys 124 11 these these DT cord-304556-1f47gvys 124 12 scarce scarce JJ cord-304556-1f47gvys 124 13 apoptotic apoptotic JJ cord-304556-1f47gvys 124 14 cells cell NNS cord-304556-1f47gvys 124 15 even even RB cord-304556-1f47gvys 124 16 when when WRB cord-304556-1f47gvys 124 17 their -PRON- PRP$ cord-304556-1f47gvys 124 18 efferocytic efferocytic JJ cord-304556-1f47gvys 124 19 function function NN cord-304556-1f47gvys 124 20 is be VBZ cord-304556-1f47gvys 124 21 partly partly RB cord-304556-1f47gvys 124 22 disrupted disrupt VBN cord-304556-1f47gvys 124 23 . . . cord-304556-1f47gvys 125 1 For for IN cord-304556-1f47gvys 125 2 example example NN cord-304556-1f47gvys 125 3 , , , cord-304556-1f47gvys 125 4 deletion deletion NN cord-304556-1f47gvys 125 5 of of IN cord-304556-1f47gvys 125 6 Axl Axl NNP cord-304556-1f47gvys 125 7 , , , cord-304556-1f47gvys 125 8 which which WDT cord-304556-1f47gvys 125 9 is be VBZ cord-304556-1f47gvys 125 10 highly highly RB cord-304556-1f47gvys 125 11 expressed express VBN cord-304556-1f47gvys 125 12 on on IN cord-304556-1f47gvys 125 13 murine murine JJ cord-304556-1f47gvys 125 14 airway airway NN cord-304556-1f47gvys 125 15 macrophages macrophage NNS cord-304556-1f47gvys 125 16 , , , cord-304556-1f47gvys 125 17 does do VBZ cord-304556-1f47gvys 125 18 not not RB cord-304556-1f47gvys 125 19 cause cause VB cord-304556-1f47gvys 125 20 accumulation accumulation NN cord-304556-1f47gvys 125 21 of of IN cord-304556-1f47gvys 125 22 necrotic necrotic JJ cord-304556-1f47gvys 125 23 cell cell NN cord-304556-1f47gvys 125 24 debris debris NN cord-304556-1f47gvys 125 25 and and CC cord-304556-1f47gvys 125 26 lung lung NN cord-304556-1f47gvys 125 27 inflammation inflammation NN cord-304556-1f47gvys 125 28 in in IN cord-304556-1f47gvys 125 29 the the DT cord-304556-1f47gvys 125 30 absence absence NN cord-304556-1f47gvys 125 31 of of IN cord-304556-1f47gvys 125 32 accompanying accompany VBG cord-304556-1f47gvys 125 33 infection infection NN cord-304556-1f47gvys 125 34 despite despite IN cord-304556-1f47gvys 125 35 significant significant JJ cord-304556-1f47gvys 125 36 impairment impairment NN cord-304556-1f47gvys 125 37 of of IN cord-304556-1f47gvys 125 38 the the DT cord-304556-1f47gvys 125 39 efferocytic efferocytic JJ cord-304556-1f47gvys 125 40 function function NN cord-304556-1f47gvys 125 41 of of IN cord-304556-1f47gvys 125 42 airway airway NN cord-304556-1f47gvys 125 43 macrophages macrophage NNS cord-304556-1f47gvys 125 44 [ [ -LRB- cord-304556-1f47gvys 125 45 2 2 CD cord-304556-1f47gvys 125 46 ] ] -RRB- cord-304556-1f47gvys 125 47 . . . cord-304556-1f47gvys 126 1 Similarly similarly RB cord-304556-1f47gvys 126 2 , , , cord-304556-1f47gvys 126 3 blockade blockade NN cord-304556-1f47gvys 126 4 of of IN cord-304556-1f47gvys 126 5 apoptotic apoptotic JJ cord-304556-1f47gvys 126 6 cell cell NN cord-304556-1f47gvys 126 7 uptake uptake NN cord-304556-1f47gvys 126 8 by by IN cord-304556-1f47gvys 126 9 airway airway NN cord-304556-1f47gvys 126 10 epithelial epithelial JJ cord-304556-1f47gvys 126 11 cells cell NNS cord-304556-1f47gvys 126 12 through through IN cord-304556-1f47gvys 126 13 cell cell NN cord-304556-1f47gvys 126 14 type type NN cord-304556-1f47gvys 126 15 - - HYPH cord-304556-1f47gvys 126 16 specific specific JJ cord-304556-1f47gvys 126 17 deletion deletion NN cord-304556-1f47gvys 126 18 of of IN cord-304556-1f47gvys 126 19 the the DT cord-304556-1f47gvys 126 20 small small JJ cord-304556-1f47gvys 126 21 GTPase GTPase NNP cord-304556-1f47gvys 126 22 Rac1 Rac1 NNP cord-304556-1f47gvys 126 23 , , , cord-304556-1f47gvys 126 24 which which WDT cord-304556-1f47gvys 126 25 is be VBZ cord-304556-1f47gvys 126 26 required require VBN cord-304556-1f47gvys 126 27 for for IN cord-304556-1f47gvys 126 28 efferocytosis efferocytosis NN cord-304556-1f47gvys 126 29 mediated mediate VBN cord-304556-1f47gvys 126 30 by by IN cord-304556-1f47gvys 126 31 several several JJ cord-304556-1f47gvys 126 32 classes class NNS cord-304556-1f47gvys 126 33 of of IN cord-304556-1f47gvys 126 34 engulfment engulfment NN cord-304556-1f47gvys 126 35 receptors receptor NNS cord-304556-1f47gvys 126 36 , , , cord-304556-1f47gvys 126 37 does do VBZ cord-304556-1f47gvys 126 38 not not RB cord-304556-1f47gvys 126 39 affect affect VB cord-304556-1f47gvys 126 40 the the DT cord-304556-1f47gvys 126 41 integrity integrity NN cord-304556-1f47gvys 126 42 and and CC cord-304556-1f47gvys 126 43 responses response NNS cord-304556-1f47gvys 126 44 of of IN cord-304556-1f47gvys 126 45 the the DT cord-304556-1f47gvys 126 46 epithelial epithelial JJ cord-304556-1f47gvys 126 47 barrier barrier NN cord-304556-1f47gvys 126 48 without without IN cord-304556-1f47gvys 126 49 administration administration NN cord-304556-1f47gvys 126 50 of of IN cord-304556-1f47gvys 126 51 exogenous exogenous JJ cord-304556-1f47gvys 126 52 apoptotic apoptotic JJ cord-304556-1f47gvys 126 53 cells cell NNS cord-304556-1f47gvys 126 54 or or CC cord-304556-1f47gvys 126 55 induction induction NN cord-304556-1f47gvys 126 56 of of IN cord-304556-1f47gvys 126 57 allergic allergic JJ cord-304556-1f47gvys 126 58 airway airway NN cord-304556-1f47gvys 126 59 inflammation inflammation NN cord-304556-1f47gvys 126 60 [ [ -LRB- cord-304556-1f47gvys 126 61 68 68 CD cord-304556-1f47gvys 126 62 ] ] -RRB- cord-304556-1f47gvys 126 63 . . . cord-304556-1f47gvys 127 1 In in IN cord-304556-1f47gvys 127 2 health health NN cord-304556-1f47gvys 127 3 , , , cord-304556-1f47gvys 127 4 apoptotic apoptotic JJ cord-304556-1f47gvys 127 5 cells cell NNS cord-304556-1f47gvys 127 6 are be VBP cord-304556-1f47gvys 127 7 essentially essentially RB cord-304556-1f47gvys 127 8 undetectable undetectable JJ cord-304556-1f47gvys 127 9 in in IN cord-304556-1f47gvys 127 10 the the DT cord-304556-1f47gvys 127 11 lung lung NN cord-304556-1f47gvys 127 12 tissue tissue NN cord-304556-1f47gvys 127 13 [ [ -LRB- cord-304556-1f47gvys 127 14 69 69 CD cord-304556-1f47gvys 127 15 ] ] -RRB- cord-304556-1f47gvys 127 16 , , , cord-304556-1f47gvys 127 17 and and CC cord-304556-1f47gvys 127 18 immune immune JJ cord-304556-1f47gvys 127 19 cells cell NNS cord-304556-1f47gvys 127 20 infiltrating infiltrate VBG cord-304556-1f47gvys 127 21 the the DT cord-304556-1f47gvys 127 22 airways airway NNS cord-304556-1f47gvys 127 23 which which WDT cord-304556-1f47gvys 127 24 undergo undergo VBP cord-304556-1f47gvys 127 25 apoptosis apoptosis NN cord-304556-1f47gvys 127 26 are be VBP cord-304556-1f47gvys 127 27 rapidly rapidly RB cord-304556-1f47gvys 127 28 cleared clear VBN cord-304556-1f47gvys 127 29 by by IN cord-304556-1f47gvys 127 30 airway airway NN cord-304556-1f47gvys 127 31 macrophages macrophage NNS cord-304556-1f47gvys 127 32 in in IN cord-304556-1f47gvys 127 33 models model NNS cord-304556-1f47gvys 127 34 of of IN cord-304556-1f47gvys 127 35 acute acute JJ cord-304556-1f47gvys 127 36 microbial microbial JJ cord-304556-1f47gvys 127 37 infection infection NN cord-304556-1f47gvys 127 38 - - HYPH cord-304556-1f47gvys 127 39 related relate VBN cord-304556-1f47gvys 127 40 lung lung NN cord-304556-1f47gvys 127 41 inflammation inflammation NN cord-304556-1f47gvys 127 42 [ [ -LRB- cord-304556-1f47gvys 127 43 70 70 CD cord-304556-1f47gvys 127 44 ] ] -RRB- cord-304556-1f47gvys 127 45 . . . cord-304556-1f47gvys 128 1 Respiratory respiratory JJ cord-304556-1f47gvys 128 2 infections infection NNS cord-304556-1f47gvys 128 3 are be VBP cord-304556-1f47gvys 128 4 therefore therefore RB cord-304556-1f47gvys 128 5 not not RB cord-304556-1f47gvys 128 6 associated associate VBN cord-304556-1f47gvys 128 7 with with IN cord-304556-1f47gvys 128 8 persistent persistent JJ cord-304556-1f47gvys 128 9 accumulation accumulation NN cord-304556-1f47gvys 128 10 of of IN cord-304556-1f47gvys 128 11 large large JJ cord-304556-1f47gvys 128 12 quantities quantity NNS cord-304556-1f47gvys 128 13 of of IN cord-304556-1f47gvys 128 14 apoptotic apoptotic JJ cord-304556-1f47gvys 128 15 cells cell NNS cord-304556-1f47gvys 128 16 in in IN cord-304556-1f47gvys 128 17 the the DT cord-304556-1f47gvys 128 18 airspaces airspace NNS cord-304556-1f47gvys 128 19 . . . cord-304556-1f47gvys 129 1 However however RB cord-304556-1f47gvys 129 2 , , , cord-304556-1f47gvys 129 3 increased increase VBN cord-304556-1f47gvys 129 4 numbers number NNS cord-304556-1f47gvys 129 5 of of IN cord-304556-1f47gvys 129 6 dying die VBG cord-304556-1f47gvys 129 7 cells cell NNS cord-304556-1f47gvys 129 8 are be VBP cord-304556-1f47gvys 129 9 detected detect VBN cord-304556-1f47gvys 129 10 in in IN cord-304556-1f47gvys 129 11 the the DT cord-304556-1f47gvys 129 12 airspaces airspace NNS cord-304556-1f47gvys 129 13 of of IN cord-304556-1f47gvys 129 14 patients patient NNS cord-304556-1f47gvys 129 15 with with IN cord-304556-1f47gvys 129 16 several several JJ cord-304556-1f47gvys 129 17 aetiologically aetiologically RB cord-304556-1f47gvys 129 18 distinct distinct JJ cord-304556-1f47gvys 129 19 chronic chronic JJ cord-304556-1f47gvys 129 20 inflammatory inflammatory JJ cord-304556-1f47gvys 129 21 lung lung NN cord-304556-1f47gvys 129 22 diseases disease NNS cord-304556-1f47gvys 129 23 [ [ -LRB- cord-304556-1f47gvys 129 24 71 71 CD cord-304556-1f47gvys 129 25 ] ] -RRB- cord-304556-1f47gvys 129 26 . . . cord-304556-1f47gvys 130 1 Although although IN cord-304556-1f47gvys 130 2 higher high JJR cord-304556-1f47gvys 130 3 frequencies frequency NNS cord-304556-1f47gvys 130 4 of of IN cord-304556-1f47gvys 130 5 apoptotic apoptotic JJ cord-304556-1f47gvys 130 6 cells cell NNS cord-304556-1f47gvys 130 7 in in IN cord-304556-1f47gvys 130 8 these these DT cord-304556-1f47gvys 130 9 diseases disease NNS cord-304556-1f47gvys 130 10 might may MD cord-304556-1f47gvys 130 11 result result VB cord-304556-1f47gvys 130 12 either either CC cord-304556-1f47gvys 130 13 from from IN cord-304556-1f47gvys 130 14 elevated elevated JJ cord-304556-1f47gvys 130 15 rates rate NNS cord-304556-1f47gvys 130 16 of of IN cord-304556-1f47gvys 130 17 apoptotic apoptotic JJ cord-304556-1f47gvys 130 18 cell cell NN cord-304556-1f47gvys 130 19 death death NN cord-304556-1f47gvys 130 20 or or CC cord-304556-1f47gvys 130 21 defects defect NNS cord-304556-1f47gvys 130 22 in in IN cord-304556-1f47gvys 130 23 apoptotic apoptotic JJ cord-304556-1f47gvys 130 24 cell cell NN cord-304556-1f47gvys 130 25 removal removal NN cord-304556-1f47gvys 130 26 , , , cord-304556-1f47gvys 130 27 experimental experimental JJ cord-304556-1f47gvys 130 28 evidence evidence NN cord-304556-1f47gvys 130 29 suggests suggest VBZ cord-304556-1f47gvys 130 30 that that IN cord-304556-1f47gvys 130 31 reduced reduce VBN cord-304556-1f47gvys 130 32 efficiency efficiency NN cord-304556-1f47gvys 130 33 of of IN cord-304556-1f47gvys 130 34 efferocytosis efferocytosis NN cord-304556-1f47gvys 130 35 , , , cord-304556-1f47gvys 130 36 predominantly predominantly RB cord-304556-1f47gvys 130 37 by by IN cord-304556-1f47gvys 130 38 airway airway NN cord-304556-1f47gvys 130 39 macrophages macrophage NNS cord-304556-1f47gvys 130 40 , , , cord-304556-1f47gvys 130 41 plays play VBZ cord-304556-1f47gvys 130 42 a a DT cord-304556-1f47gvys 130 43 key key JJ cord-304556-1f47gvys 130 44 role role NN cord-304556-1f47gvys 130 45 in in IN cord-304556-1f47gvys 130 46 this this DT cord-304556-1f47gvys 130 47 pathological pathological JJ cord-304556-1f47gvys 130 48 process process NN cord-304556-1f47gvys 130 49 [ [ -LRB- cord-304556-1f47gvys 130 50 72 72 CD cord-304556-1f47gvys 130 51 , , , cord-304556-1f47gvys 130 52 73 73 CD cord-304556-1f47gvys 130 53 ] ] -RRB- cord-304556-1f47gvys 130 54 . . . cord-304556-1f47gvys 131 1 The the DT cord-304556-1f47gvys 131 2 most most RBS cord-304556-1f47gvys 131 3 comprehensive comprehensive JJ cord-304556-1f47gvys 131 4 analysis analysis NN cord-304556-1f47gvys 131 5 of of IN cord-304556-1f47gvys 131 6 defects defect NNS cord-304556-1f47gvys 131 7 in in IN cord-304556-1f47gvys 131 8 apoptotic apoptotic JJ cord-304556-1f47gvys 131 9 cell cell NN cord-304556-1f47gvys 131 10 clearance clearance NN cord-304556-1f47gvys 131 11 has have VBZ cord-304556-1f47gvys 131 12 been be VBN cord-304556-1f47gvys 131 13 performed perform VBN cord-304556-1f47gvys 131 14 in in IN cord-304556-1f47gvys 131 15 chronic chronic JJ cord-304556-1f47gvys 131 16 obstructive obstructive JJ cord-304556-1f47gvys 131 17 pulmonary pulmonary JJ cord-304556-1f47gvys 131 18 disease disease NN cord-304556-1f47gvys 131 19 ( ( -LRB- cord-304556-1f47gvys 131 20 COPD COPD NNP cord-304556-1f47gvys 131 21 ) ) -RRB- cord-304556-1f47gvys 131 22 , , , cord-304556-1f47gvys 131 23 which which WDT cord-304556-1f47gvys 131 24 is be VBZ cord-304556-1f47gvys 131 25 a a DT cord-304556-1f47gvys 131 26 chronic chronic JJ cord-304556-1f47gvys 131 27 lung lung NN cord-304556-1f47gvys 131 28 disease disease NN cord-304556-1f47gvys 131 29 characterised characterise VBN cord-304556-1f47gvys 131 30 by by IN cord-304556-1f47gvys 131 31 un un NNP cord-304556-1f47gvys 131 32 - - HYPH cord-304556-1f47gvys 131 33 resolving resolve VBG cord-304556-1f47gvys 131 34 inflammation inflammation NN cord-304556-1f47gvys 131 35 due due IN cord-304556-1f47gvys 131 36 to to IN cord-304556-1f47gvys 131 37 accumulation accumulation NN cord-304556-1f47gvys 131 38 of of IN cord-304556-1f47gvys 131 39 activated activate VBN cord-304556-1f47gvys 131 40 neutrophils neutrophil NNS cord-304556-1f47gvys 131 41 and and CC cord-304556-1f47gvys 131 42 T t NN cord-304556-1f47gvys 131 43 cells cell NNS cord-304556-1f47gvys 131 44 causing cause VBG cord-304556-1f47gvys 131 45 small small JJ cord-304556-1f47gvys 131 46 - - HYPH cord-304556-1f47gvys 131 47 airway airway NN cord-304556-1f47gvys 131 48 obstruction obstruction NN cord-304556-1f47gvys 131 49 , , , cord-304556-1f47gvys 131 50 peribronchial peribronchial JJ cord-304556-1f47gvys 131 51 fibrosis fibrosis NN cord-304556-1f47gvys 131 52 and/or and/or CC cord-304556-1f47gvys 131 53 destruction destruction NN cord-304556-1f47gvys 131 54 of of IN cord-304556-1f47gvys 131 55 airway airway NN cord-304556-1f47gvys 131 56 walls wall NNS cord-304556-1f47gvys 131 57 ( ( -LRB- cord-304556-1f47gvys 131 58 emphysema emphysema NN cord-304556-1f47gvys 131 59 ) ) -RRB- cord-304556-1f47gvys 131 60 . . . cord-304556-1f47gvys 132 1 These these DT cord-304556-1f47gvys 132 2 pathological pathological JJ cord-304556-1f47gvys 132 3 processes process NNS cord-304556-1f47gvys 132 4 lead lead VBP cord-304556-1f47gvys 132 5 to to IN cord-304556-1f47gvys 132 6 progressive progressive JJ cord-304556-1f47gvys 132 7 destruction destruction NN cord-304556-1f47gvys 132 8 of of IN cord-304556-1f47gvys 132 9 lung lung NN cord-304556-1f47gvys 132 10 parenchyma parenchyma NNS cord-304556-1f47gvys 132 11 and and CC cord-304556-1f47gvys 132 12 , , , cord-304556-1f47gvys 132 13 as as IN cord-304556-1f47gvys 132 14 a a DT cord-304556-1f47gvys 132 15 consequence consequence NN cord-304556-1f47gvys 132 16 , , , cord-304556-1f47gvys 132 17 airflow airflow NN cord-304556-1f47gvys 132 18 limitation limitation NN cord-304556-1f47gvys 132 19 that that WDT cord-304556-1f47gvys 132 20 is be VBZ cord-304556-1f47gvys 132 21 not not RB cord-304556-1f47gvys 132 22 fully fully RB cord-304556-1f47gvys 132 23 reversible reversible JJ cord-304556-1f47gvys 132 24 in in IN cord-304556-1f47gvys 132 25 patients patient NNS cord-304556-1f47gvys 132 26 with with IN cord-304556-1f47gvys 132 27 emphysema emphysema NN cord-304556-1f47gvys 132 28 , , , cord-304556-1f47gvys 132 29 and and CC cord-304556-1f47gvys 132 30 in in IN cord-304556-1f47gvys 132 31 other other JJ cord-304556-1f47gvys 132 32 subtypes subtype NNS cord-304556-1f47gvys 132 33 of of IN cord-304556-1f47gvys 132 34 COPD COPD NNP cord-304556-1f47gvys 132 35 [ [ -LRB- cord-304556-1f47gvys 132 36 74 74 CD cord-304556-1f47gvys 132 37 ] ] -RRB- cord-304556-1f47gvys 132 38 . . . cord-304556-1f47gvys 133 1 Historically historically RB cord-304556-1f47gvys 133 2 , , , cord-304556-1f47gvys 133 3 lung lung NN cord-304556-1f47gvys 133 4 pathology pathology NN cord-304556-1f47gvys 133 5 in in IN cord-304556-1f47gvys 133 6 COPD COPD NNP cord-304556-1f47gvys 133 7 was be VBD cord-304556-1f47gvys 133 8 attributed attribute VBN cord-304556-1f47gvys 133 9 to to IN cord-304556-1f47gvys 133 10 alterations alteration NNS cord-304556-1f47gvys 133 11 in in IN cord-304556-1f47gvys 133 12 the the DT cord-304556-1f47gvys 133 13 protease protease NN cord-304556-1f47gvys 133 14 / / SYM cord-304556-1f47gvys 133 15 anti anti JJ cord-304556-1f47gvys 133 16 - - JJ cord-304556-1f47gvys 133 17 protease protease JJ cord-304556-1f47gvys 133 18 balance balance NN cord-304556-1f47gvys 133 19 and and CC cord-304556-1f47gvys 133 20 oxidative oxidative JJ cord-304556-1f47gvys 133 21 stress stress NN cord-304556-1f47gvys 133 22 caused cause VBN cord-304556-1f47gvys 133 23 by by IN cord-304556-1f47gvys 133 24 cigarette cigarette NN cord-304556-1f47gvys 133 25 smoking smoking NN cord-304556-1f47gvys 133 26 , , , cord-304556-1f47gvys 133 27 which which WDT cord-304556-1f47gvys 133 28 is be VBZ cord-304556-1f47gvys 133 29 the the DT cord-304556-1f47gvys 133 30 main main JJ cord-304556-1f47gvys 133 31 risk risk NN cord-304556-1f47gvys 133 32 factor factor NN cord-304556-1f47gvys 133 33 for for IN cord-304556-1f47gvys 133 34 COPD COPD NNP cord-304556-1f47gvys 133 35 . . . cord-304556-1f47gvys 134 1 However however RB cord-304556-1f47gvys 134 2 , , , cord-304556-1f47gvys 134 3 there there EX cord-304556-1f47gvys 134 4 is be VBZ cord-304556-1f47gvys 134 5 evidence evidence NN cord-304556-1f47gvys 134 6 that that WDT cord-304556-1f47gvys 134 7 indicates indicate VBZ cord-304556-1f47gvys 134 8 an an DT cord-304556-1f47gvys 134 9 important important JJ cord-304556-1f47gvys 134 10 role role NN cord-304556-1f47gvys 134 11 of of IN cord-304556-1f47gvys 134 12 aberrant aberrant JJ cord-304556-1f47gvys 134 13 apoptosis apoptosis NN cord-304556-1f47gvys 134 14 and and CC cord-304556-1f47gvys 134 15 apoptotic apoptotic JJ cord-304556-1f47gvys 134 16 cell cell NN cord-304556-1f47gvys 134 17 clearance clearance NN cord-304556-1f47gvys 134 18 in in IN cord-304556-1f47gvys 134 19 the the DT cord-304556-1f47gvys 134 20 lung lung NN cord-304556-1f47gvys 134 21 damage damage NN cord-304556-1f47gvys 134 22 observed observe VBN cord-304556-1f47gvys 134 23 in in IN cord-304556-1f47gvys 134 24 COPD COPD NNP cord-304556-1f47gvys 134 25 [ [ -LRB- cord-304556-1f47gvys 134 26 75 75 CD cord-304556-1f47gvys 134 27 ] ] -RRB- cord-304556-1f47gvys 134 28 . . . cord-304556-1f47gvys 135 1 Several several JJ cord-304556-1f47gvys 135 2 reports report NNS cord-304556-1f47gvys 135 3 demonstrate demonstrate VBP cord-304556-1f47gvys 135 4 accumulation accumulation NN cord-304556-1f47gvys 135 5 of of IN cord-304556-1f47gvys 135 6 apoptotic apoptotic JJ cord-304556-1f47gvys 135 7 epithelial epithelial NN cord-304556-1f47gvys 135 8 , , , cord-304556-1f47gvys 135 9 endothelial endothelial JJ cord-304556-1f47gvys 135 10 and and CC cord-304556-1f47gvys 135 11 immune immune JJ cord-304556-1f47gvys 135 12 cells cell NNS cord-304556-1f47gvys 135 13 in in IN cord-304556-1f47gvys 135 14 the the DT cord-304556-1f47gvys 135 15 lungs lung NNS cord-304556-1f47gvys 135 16 of of IN cord-304556-1f47gvys 135 17 patients patient NNS cord-304556-1f47gvys 135 18 with with IN cord-304556-1f47gvys 135 19 COPD COPD NNP cord-304556-1f47gvys 135 20 and/or and/or CC cord-304556-1f47gvys 135 21 emphysema emphysema NN cord-304556-1f47gvys 135 22 [ [ -LRB- cord-304556-1f47gvys 135 23 69 69 CD cord-304556-1f47gvys 135 24 , , , cord-304556-1f47gvys 135 25 76 76 CD cord-304556-1f47gvys 135 26 , , , cord-304556-1f47gvys 135 27 77 77 CD cord-304556-1f47gvys 135 28 ] ] -RRB- cord-304556-1f47gvys 135 29 , , , cord-304556-1f47gvys 135 30 and and CC cord-304556-1f47gvys 135 31 induction induction NN cord-304556-1f47gvys 135 32 of of IN cord-304556-1f47gvys 135 33 structural structural JJ cord-304556-1f47gvys 135 34 airway airway NN cord-304556-1f47gvys 135 35 cell cell NN cord-304556-1f47gvys 135 36 apoptosis apoptosis NN cord-304556-1f47gvys 135 37 is be VBZ cord-304556-1f47gvys 135 38 sufficient sufficient JJ cord-304556-1f47gvys 135 39 to to TO cord-304556-1f47gvys 135 40 cause cause VB cord-304556-1f47gvys 135 41 emphysematous emphysematous JJ cord-304556-1f47gvys 135 42 changes change NNS cord-304556-1f47gvys 135 43 in in IN cord-304556-1f47gvys 135 44 mice mouse NNS cord-304556-1f47gvys 135 45 [ [ -LRB- cord-304556-1f47gvys 135 46 78 78 CD cord-304556-1f47gvys 135 47 ] ] -RRB- cord-304556-1f47gvys 135 48 . . . cord-304556-1f47gvys 136 1 In in IN cord-304556-1f47gvys 136 2 a a DT cord-304556-1f47gvys 136 3 series series NN cord-304556-1f47gvys 136 4 of of IN cord-304556-1f47gvys 136 5 elegant elegant JJ cord-304556-1f47gvys 136 6 studies study NNS cord-304556-1f47gvys 136 7 , , , cord-304556-1f47gvys 136 8 Hodge Hodge NNP cord-304556-1f47gvys 136 9 and and CC cord-304556-1f47gvys 136 10 co co NNS cord-304556-1f47gvys 136 11 - - NNS cord-304556-1f47gvys 136 12 workers worker NNS cord-304556-1f47gvys 136 13 demonstrate demonstrate VBP cord-304556-1f47gvys 136 14 that that IN cord-304556-1f47gvys 136 15 increases increase NNS cord-304556-1f47gvys 136 16 in in IN cord-304556-1f47gvys 136 17 the the DT cord-304556-1f47gvys 136 18 numbers number NNS cord-304556-1f47gvys 136 19 of of IN cord-304556-1f47gvys 136 20 apoptotic apoptotic JJ cord-304556-1f47gvys 136 21 cells cell NNS cord-304556-1f47gvys 136 22 detected detect VBN cord-304556-1f47gvys 136 23 in in IN cord-304556-1f47gvys 136 24 the the DT cord-304556-1f47gvys 136 25 lungs lung NNS cord-304556-1f47gvys 136 26 of of IN cord-304556-1f47gvys 136 27 patients patient NNS cord-304556-1f47gvys 136 28 with with IN cord-304556-1f47gvys 136 29 COPD COPD NNP cord-304556-1f47gvys 136 30 can can MD cord-304556-1f47gvys 136 31 be be VB cord-304556-1f47gvys 136 32 attributed attribute VBN cord-304556-1f47gvys 136 33 to to IN cord-304556-1f47gvys 136 34 significantly significantly RB cord-304556-1f47gvys 136 35 impaired impair VBN cord-304556-1f47gvys 136 36 efferocytic efferocytic JJ cord-304556-1f47gvys 136 37 function function NN cord-304556-1f47gvys 136 38 of of IN cord-304556-1f47gvys 136 39 airway airway NN cord-304556-1f47gvys 136 40 macrophages macrophage NNS cord-304556-1f47gvys 136 41 . . . cord-304556-1f47gvys 137 1 Uptake uptake NN cord-304556-1f47gvys 137 2 of of IN cord-304556-1f47gvys 137 3 apoptotic apoptotic JJ cord-304556-1f47gvys 137 4 bronchial bronchial JJ cord-304556-1f47gvys 137 5 epithelial epithelial JJ cord-304556-1f47gvys 137 6 cells cell NNS cord-304556-1f47gvys 137 7 and and CC cord-304556-1f47gvys 137 8 neutrophils neutrophil NNS cord-304556-1f47gvys 137 9 is be VBZ cord-304556-1f47gvys 137 10 significantly significantly RB cord-304556-1f47gvys 137 11 reduced reduce VBN cord-304556-1f47gvys 137 12 in in IN cord-304556-1f47gvys 137 13 bronchoalveolar bronchoalveolar JJ cord-304556-1f47gvys 137 14 lavage lavage NN cord-304556-1f47gvys 137 15 macrophages macrophage NNS cord-304556-1f47gvys 137 16 from from IN cord-304556-1f47gvys 137 17 patients patient NNS cord-304556-1f47gvys 137 18 with with IN cord-304556-1f47gvys 137 19 COPD COPD NNP cord-304556-1f47gvys 137 20 compared compare VBN cord-304556-1f47gvys 137 21 to to IN cord-304556-1f47gvys 137 22 healthy healthy JJ cord-304556-1f47gvys 137 23 controls control NNS cord-304556-1f47gvys 137 24 [ [ -LRB- cord-304556-1f47gvys 137 25 21 21 CD cord-304556-1f47gvys 137 26 , , , cord-304556-1f47gvys 137 27 22 22 CD cord-304556-1f47gvys 137 28 , , , cord-304556-1f47gvys 137 29 79 79 CD cord-304556-1f47gvys 137 30 ] ] -RRB- cord-304556-1f47gvys 137 31 , , , cord-304556-1f47gvys 137 32 and and CC cord-304556-1f47gvys 137 33 this this DT cord-304556-1f47gvys 137 34 defect defect NN cord-304556-1f47gvys 137 35 is be VBZ cord-304556-1f47gvys 137 36 more more RBR cord-304556-1f47gvys 137 37 pronounced pronounced JJ cord-304556-1f47gvys 137 38 in in IN cord-304556-1f47gvys 137 39 COPD COPD NNP cord-304556-1f47gvys 137 40 patients patient NNS cord-304556-1f47gvys 137 41 who who WP cord-304556-1f47gvys 137 42 currently currently RB cord-304556-1f47gvys 137 43 smoke smoke VBP cord-304556-1f47gvys 137 44 [ [ -LRB- cord-304556-1f47gvys 137 45 22 22 CD cord-304556-1f47gvys 137 46 ] ] -RRB- cord-304556-1f47gvys 137 47 . . . cord-304556-1f47gvys 138 1 The the DT cord-304556-1f47gvys 138 2 observed observed JJ cord-304556-1f47gvys 138 3 reductions reduction NNS cord-304556-1f47gvys 138 4 in in IN cord-304556-1f47gvys 138 5 efferocytic efferocytic JJ cord-304556-1f47gvys 138 6 potential potential NN cord-304556-1f47gvys 138 7 of of IN cord-304556-1f47gvys 138 8 airway airway JJ cord-304556-1f47gvys 138 9 macrophages macrophage NNS cord-304556-1f47gvys 138 10 in in IN cord-304556-1f47gvys 138 11 vitro vitro FW cord-304556-1f47gvys 138 12 correlate correlate VBP cord-304556-1f47gvys 138 13 with with IN cord-304556-1f47gvys 138 14 the the DT cord-304556-1f47gvys 138 15 frequency frequency NN cord-304556-1f47gvys 138 16 of of IN cord-304556-1f47gvys 138 17 apoptotic apoptotic JJ cord-304556-1f47gvys 138 18 bronchial bronchial JJ cord-304556-1f47gvys 138 19 epithelial epithelial JJ cord-304556-1f47gvys 138 20 cells cell NNS cord-304556-1f47gvys 138 21 isolated isolate VBN cord-304556-1f47gvys 138 22 from from IN cord-304556-1f47gvys 138 23 bronchial bronchial JJ cord-304556-1f47gvys 138 24 brushings brushing NNS cord-304556-1f47gvys 138 25 and and CC cord-304556-1f47gvys 138 26 are be VBP cord-304556-1f47gvys 138 27 associated associate VBN cord-304556-1f47gvys 138 28 with with IN cord-304556-1f47gvys 138 29 altered altered JJ cord-304556-1f47gvys 138 30 expression expression NN cord-304556-1f47gvys 138 31 of of IN cord-304556-1f47gvys 138 32 several several JJ cord-304556-1f47gvys 138 33 proteins protein NNS cord-304556-1f47gvys 138 34 involved involve VBN cord-304556-1f47gvys 138 35 in in IN cord-304556-1f47gvys 138 36 apoptotic apoptotic JJ cord-304556-1f47gvys 138 37 cell cell NN cord-304556-1f47gvys 138 38 recognition recognition NN cord-304556-1f47gvys 138 39 and and CC cord-304556-1f47gvys 138 40 binding binding NN cord-304556-1f47gvys 138 41 , , , cord-304556-1f47gvys 138 42 including include VBG cord-304556-1f47gvys 138 43 CD31 CD31 NNP cord-304556-1f47gvys 138 44 , , , cord-304556-1f47gvys 138 45 CD44 CD44 NNP cord-304556-1f47gvys 138 46 and and CC cord-304556-1f47gvys 138 47 LRP-1 LRP-1 NNP cord-304556-1f47gvys 139 1 /CD91 /CD91 NNP cord-304556-1f47gvys 139 2 [ [ -LRB- cord-304556-1f47gvys 139 3 22 22 CD cord-304556-1f47gvys 139 4 ] ] -RRB- cord-304556-1f47gvys 139 5 . . . cord-304556-1f47gvys 140 1 Intriguingly intriguingly RB cord-304556-1f47gvys 140 2 , , , cord-304556-1f47gvys 140 3 restoration restoration NN cord-304556-1f47gvys 140 4 of of IN cord-304556-1f47gvys 140 5 COPD COPD NNP cord-304556-1f47gvys 140 6 airway airway NNP cord-304556-1f47gvys 140 7 macrophage macrophage NN cord-304556-1f47gvys 140 8 efferocytic efferocytic JJ cord-304556-1f47gvys 140 9 function function NN cord-304556-1f47gvys 140 10 by by IN cord-304556-1f47gvys 140 11 the the DT cord-304556-1f47gvys 140 12 macrolide macrolide JJ cord-304556-1f47gvys 140 13 antibiotic antibiotic JJ cord-304556-1f47gvys 140 14 azithromycin azithromycin NNP cord-304556-1f47gvys 140 15 does do VBZ cord-304556-1f47gvys 140 16 not not RB cord-304556-1f47gvys 140 17 correlate correlate VB cord-304556-1f47gvys 140 18 with with IN cord-304556-1f47gvys 140 19 changes change NNS cord-304556-1f47gvys 140 20 in in IN cord-304556-1f47gvys 140 21 expression expression NN cord-304556-1f47gvys 140 22 of of IN cord-304556-1f47gvys 140 23 these these DT cord-304556-1f47gvys 140 24 molecules molecule NNS cord-304556-1f47gvys 140 25 [ [ -LRB- cord-304556-1f47gvys 140 26 21 21 CD cord-304556-1f47gvys 140 27 ] ] -RRB- cord-304556-1f47gvys 140 28 . . . cord-304556-1f47gvys 141 1 Instead instead RB cord-304556-1f47gvys 141 2 , , , cord-304556-1f47gvys 141 3 it -PRON- PRP cord-304556-1f47gvys 141 4 depends depend VBZ cord-304556-1f47gvys 141 5 on on IN cord-304556-1f47gvys 141 6 PtdSer PtdSer NNP cord-304556-1f47gvys 141 7 binding bind VBG cord-304556-1f47gvys 141 8 by by IN cord-304556-1f47gvys 141 9 airway airway NN cord-304556-1f47gvys 141 10 macrophages macrophage NNS cord-304556-1f47gvys 141 11 [ [ -LRB- cord-304556-1f47gvys 141 12 21 21 CD cord-304556-1f47gvys 141 13 ] ] -RRB- cord-304556-1f47gvys 141 14 , , , cord-304556-1f47gvys 141 15 suggesting suggest VBG cord-304556-1f47gvys 141 16 that that IN cord-304556-1f47gvys 141 17 deregulation deregulation NN cord-304556-1f47gvys 141 18 of of IN cord-304556-1f47gvys 141 19 PtdSer PtdSer NNP cord-304556-1f47gvys 141 20 - - HYPH cord-304556-1f47gvys 141 21 recognising recognise VBG cord-304556-1f47gvys 141 22 receptors receptor NNS cord-304556-1f47gvys 141 23 or or CC cord-304556-1f47gvys 141 24 bridging bridge VBG cord-304556-1f47gvys 141 25 molecules molecule NNS cord-304556-1f47gvys 141 26 might may MD cord-304556-1f47gvys 141 27 be be VB cord-304556-1f47gvys 141 28 responsible responsible JJ cord-304556-1f47gvys 141 29 for for IN cord-304556-1f47gvys 141 30 defective defective JJ cord-304556-1f47gvys 141 31 apoptotic apoptotic JJ cord-304556-1f47gvys 141 32 cell cell NN cord-304556-1f47gvys 141 33 removal removal NN cord-304556-1f47gvys 141 34 in in IN cord-304556-1f47gvys 141 35 COPD COPD NNP cord-304556-1f47gvys 141 36 . . . cord-304556-1f47gvys 142 1 Neither neither CC cord-304556-1f47gvys 142 2 TAM TAM NNP cord-304556-1f47gvys 142 3 nor nor CC cord-304556-1f47gvys 142 4 TIM TIM NNP cord-304556-1f47gvys 142 5 families family NNS cord-304556-1f47gvys 142 6 of of IN cord-304556-1f47gvys 142 7 PtdSer PtdSer NNP cord-304556-1f47gvys 142 8 recognition recognition NN cord-304556-1f47gvys 142 9 receptors receptor NNS cord-304556-1f47gvys 142 10 have have VBP cord-304556-1f47gvys 142 11 been be VBN cord-304556-1f47gvys 142 12 studied study VBN cord-304556-1f47gvys 142 13 in in IN cord-304556-1f47gvys 142 14 COPD COPD NNP cord-304556-1f47gvys 142 15 so so RB cord-304556-1f47gvys 142 16 far far RB cord-304556-1f47gvys 143 1 but but CC cord-304556-1f47gvys 143 2 , , , cord-304556-1f47gvys 143 3 surprisingly surprisingly RB cord-304556-1f47gvys 143 4 , , , cord-304556-1f47gvys 143 5 increased increase VBN cord-304556-1f47gvys 143 6 expression expression NN cord-304556-1f47gvys 143 7 of of IN cord-304556-1f47gvys 143 8 MerTK mertk NN cord-304556-1f47gvys 143 9 is be VBZ cord-304556-1f47gvys 143 10 observed observe VBN cord-304556-1f47gvys 143 11 on on IN cord-304556-1f47gvys 143 12 airway airway NN cord-304556-1f47gvys 143 13 macrophages macrophage NNS cord-304556-1f47gvys 143 14 from from IN cord-304556-1f47gvys 143 15 cigarette cigarette NN cord-304556-1f47gvys 143 16 smokers smoker NNS cord-304556-1f47gvys 143 17 [ [ -LRB- cord-304556-1f47gvys 143 18 18 18 CD cord-304556-1f47gvys 143 19 ] ] -RRB- cord-304556-1f47gvys 143 20 , , , cord-304556-1f47gvys 143 21 which which WDT cord-304556-1f47gvys 143 22 are be VBP cord-304556-1f47gvys 143 23 also also RB cord-304556-1f47gvys 143 24 characterised characterise VBN cord-304556-1f47gvys 143 25 by by IN cord-304556-1f47gvys 143 26 impaired impaired JJ cord-304556-1f47gvys 143 27 apoptotic apoptotic JJ cord-304556-1f47gvys 143 28 cell cell NN cord-304556-1f47gvys 143 29 uptake uptake NN cord-304556-1f47gvys 143 30 compared compare VBN cord-304556-1f47gvys 143 31 to to IN cord-304556-1f47gvys 143 32 cells cell NNS cord-304556-1f47gvys 143 33 from from IN cord-304556-1f47gvys 143 34 healthy healthy JJ cord-304556-1f47gvys 143 35 nonsmokers nonsmoker NNS cord-304556-1f47gvys 143 36 [ [ -LRB- cord-304556-1f47gvys 143 37 18 18 CD cord-304556-1f47gvys 143 38 , , , cord-304556-1f47gvys 143 39 22 22 CD cord-304556-1f47gvys 143 40 ] ] -RRB- cord-304556-1f47gvys 143 41 . . . cord-304556-1f47gvys 144 1 This this DT cord-304556-1f47gvys 144 2 observation observation NN cord-304556-1f47gvys 144 3 indicates indicate VBZ cord-304556-1f47gvys 144 4 that that IN cord-304556-1f47gvys 144 5 upregulation upregulation NN cord-304556-1f47gvys 144 6 of of IN cord-304556-1f47gvys 144 7 MerTK mertk NN cord-304556-1f47gvys 144 8 is be VBZ cord-304556-1f47gvys 144 9 not not RB cord-304556-1f47gvys 144 10 sufficient sufficient JJ cord-304556-1f47gvys 144 11 to to TO cord-304556-1f47gvys 144 12 restore restore VB cord-304556-1f47gvys 144 13 the the DT cord-304556-1f47gvys 144 14 efforocytic efforocytic JJ cord-304556-1f47gvys 144 15 function function NN cord-304556-1f47gvys 144 16 of of IN cord-304556-1f47gvys 144 17 airway airway NN cord-304556-1f47gvys 144 18 macrophages macrophage NNS cord-304556-1f47gvys 144 19 to to IN cord-304556-1f47gvys 144 20 normal normal JJ cord-304556-1f47gvys 144 21 levels level NNS cord-304556-1f47gvys 144 22 and and CC cord-304556-1f47gvys 144 23 other other JJ cord-304556-1f47gvys 144 24 PtdSer PtdSer NNP cord-304556-1f47gvys 144 25 receptors receptor NNS cord-304556-1f47gvys 144 26 , , , cord-304556-1f47gvys 144 27 such such JJ cord-304556-1f47gvys 144 28 as as IN cord-304556-1f47gvys 144 29 Axl Axl NNP cord-304556-1f47gvys 144 30 , , , cord-304556-1f47gvys 144 31 which which WDT cord-304556-1f47gvys 144 32 is be VBZ cord-304556-1f47gvys 144 33 highly highly RB cord-304556-1f47gvys 144 34 expressed express VBN cord-304556-1f47gvys 144 35 on on IN cord-304556-1f47gvys 144 36 mouse mouse NN cord-304556-1f47gvys 144 37 airway airway NN cord-304556-1f47gvys 144 38 macrophages macrophage NNS cord-304556-1f47gvys 144 39 [ [ -LRB- cord-304556-1f47gvys 144 40 2 2 CD cord-304556-1f47gvys 144 41 ] ] -RRB- cord-304556-1f47gvys 144 42 , , , cord-304556-1f47gvys 144 43 might may MD cord-304556-1f47gvys 144 44 play play VB cord-304556-1f47gvys 144 45 a a DT cord-304556-1f47gvys 144 46 more more RBR cord-304556-1f47gvys 144 47 prominent prominent JJ cord-304556-1f47gvys 144 48 role role NN cord-304556-1f47gvys 144 49 . . . cord-304556-1f47gvys 145 1 Apart apart RB cord-304556-1f47gvys 145 2 from from IN cord-304556-1f47gvys 145 3 potential potential JJ cord-304556-1f47gvys 145 4 alterations alteration NNS cord-304556-1f47gvys 145 5 in in IN cord-304556-1f47gvys 145 6 PtdSer ptdser JJ cord-304556-1f47gvys 145 7 receptor receptor NN cord-304556-1f47gvys 145 8 expression expression NN cord-304556-1f47gvys 145 9 and and CC cord-304556-1f47gvys 145 10 function function NN cord-304556-1f47gvys 145 11 , , , cord-304556-1f47gvys 145 12 which which WDT cord-304556-1f47gvys 145 13 require require VBP cord-304556-1f47gvys 145 14 more more RBR cord-304556-1f47gvys 145 15 detailed detailed JJ cord-304556-1f47gvys 145 16 studies study NNS cord-304556-1f47gvys 145 17 , , , cord-304556-1f47gvys 145 18 several several JJ cord-304556-1f47gvys 145 19 other other JJ cord-304556-1f47gvys 145 20 mechanisms mechanism NNS cord-304556-1f47gvys 145 21 might may MD cord-304556-1f47gvys 145 22 be be VB cord-304556-1f47gvys 145 23 involved involve VBN cord-304556-1f47gvys 145 24 in in IN cord-304556-1f47gvys 145 25 efferocytosis efferocytosis NN cord-304556-1f47gvys 145 26 defects defect NNS cord-304556-1f47gvys 145 27 observed observe VBN cord-304556-1f47gvys 145 28 in in IN cord-304556-1f47gvys 145 29 COPD COPD NNP cord-304556-1f47gvys 145 30 . . . cord-304556-1f47gvys 146 1 Significant significant JJ cord-304556-1f47gvys 146 2 impairment impairment NN cord-304556-1f47gvys 146 3 of of IN cord-304556-1f47gvys 146 4 apoptotic apoptotic JJ cord-304556-1f47gvys 146 5 cell cell NN cord-304556-1f47gvys 146 6 uptake uptake NN cord-304556-1f47gvys 146 7 by by IN cord-304556-1f47gvys 146 8 airway airway NN cord-304556-1f47gvys 146 9 macrophages macrophage NNS cord-304556-1f47gvys 146 10 from from IN cord-304556-1f47gvys 146 11 smokers smoker NNS cord-304556-1f47gvys 146 12 indicates indicate VBZ cord-304556-1f47gvys 146 13 an an DT cord-304556-1f47gvys 146 14 important important JJ cord-304556-1f47gvys 146 15 role role NN cord-304556-1f47gvys 146 16 of of IN cord-304556-1f47gvys 146 17 oxidative oxidative JJ cord-304556-1f47gvys 146 18 stress stress NN cord-304556-1f47gvys 146 19 caused cause VBN cord-304556-1f47gvys 146 20 by by IN cord-304556-1f47gvys 146 21 cigarette cigarette NN cord-304556-1f47gvys 146 22 smoke smoke NN cord-304556-1f47gvys 146 23 components component NNS cord-304556-1f47gvys 146 24 in in IN cord-304556-1f47gvys 146 25 this this DT cord-304556-1f47gvys 146 26 process process NN cord-304556-1f47gvys 146 27 [ [ -LRB- cord-304556-1f47gvys 146 28 18 18 CD cord-304556-1f47gvys 146 29 , , , cord-304556-1f47gvys 146 30 22 22 CD cord-304556-1f47gvys 146 31 ] ] -RRB- cord-304556-1f47gvys 146 32 . . . cord-304556-1f47gvys 147 1 In in IN cord-304556-1f47gvys 147 2 mice mouse NNS cord-304556-1f47gvys 147 3 , , , cord-304556-1f47gvys 147 4 cigarette cigarette NN cord-304556-1f47gvys 147 5 smoke smoke NN cord-304556-1f47gvys 147 6 exposure exposure NN cord-304556-1f47gvys 147 7 , , , cord-304556-1f47gvys 147 8 which which WDT cord-304556-1f47gvys 147 9 is be VBZ cord-304556-1f47gvys 147 10 sufficient sufficient JJ cord-304556-1f47gvys 147 11 to to TO cord-304556-1f47gvys 147 12 induce induce VB cord-304556-1f47gvys 147 13 emphysema emphysema NN cord-304556-1f47gvys 147 14 [ [ -LRB- cord-304556-1f47gvys 147 15 80 80 CD cord-304556-1f47gvys 147 16 ] ] -RRB- cord-304556-1f47gvys 147 17 , , , cord-304556-1f47gvys 147 18 significantly significantly RB cord-304556-1f47gvys 147 19 suppresses suppress VBZ cord-304556-1f47gvys 147 20 efferocytosis efferocytosis NN cord-304556-1f47gvys 147 21 by by IN cord-304556-1f47gvys 147 22 airway airway NN cord-304556-1f47gvys 147 23 macrophages macrophage NNS cord-304556-1f47gvys 147 24 in in IN cord-304556-1f47gvys 147 25 vivo vivo NN cord-304556-1f47gvys 147 26 and and CC cord-304556-1f47gvys 147 27 in in IN cord-304556-1f47gvys 147 28 vitro vitro FW cord-304556-1f47gvys 147 29 , , , cord-304556-1f47gvys 147 30 and and CC cord-304556-1f47gvys 147 31 this this DT cord-304556-1f47gvys 147 32 effect effect NN cord-304556-1f47gvys 147 33 is be VBZ cord-304556-1f47gvys 147 34 reversible reversible JJ cord-304556-1f47gvys 147 35 by by IN cord-304556-1f47gvys 147 36 treatment treatment NN cord-304556-1f47gvys 147 37 with with IN cord-304556-1f47gvys 147 38 antioxidants antioxidant NNS cord-304556-1f47gvys 147 39 or or CC cord-304556-1f47gvys 147 40 overexpression overexpression NN cord-304556-1f47gvys 147 41 of of IN cord-304556-1f47gvys 147 42 extracellular extracellular JJ cord-304556-1f47gvys 147 43 superoxide superoxide NN cord-304556-1f47gvys 147 44 dismutase dismutase NN cord-304556-1f47gvys 147 45 [ [ -LRB- cord-304556-1f47gvys 147 46 81 81 CD cord-304556-1f47gvys 147 47 , , , cord-304556-1f47gvys 147 48 82 82 CD cord-304556-1f47gvys 147 49 ] ] -RRB- cord-304556-1f47gvys 147 50 . . . cord-304556-1f47gvys 148 1 Macrophage macrophage NN cord-304556-1f47gvys 148 2 phagocytosis phagocytosis NN cord-304556-1f47gvys 148 3 of of IN cord-304556-1f47gvys 148 4 apoptotic apoptotic JJ cord-304556-1f47gvys 148 5 cells cell NNS cord-304556-1f47gvys 148 6 is be VBZ cord-304556-1f47gvys 148 7 also also RB cord-304556-1f47gvys 148 8 inhibited inhibit VBN cord-304556-1f47gvys 148 9 by by IN cord-304556-1f47gvys 148 10 the the DT cord-304556-1f47gvys 148 11 alarmin alarmin NNP cord-304556-1f47gvys 148 12 high high JJ cord-304556-1f47gvys 148 13 mobility mobility NN cord-304556-1f47gvys 148 14 group group NN cord-304556-1f47gvys 148 15 protein-1 protein-1 NNP cord-304556-1f47gvys 148 16 ( ( -LRB- cord-304556-1f47gvys 148 17 HMGB1 HMGB1 NNP cord-304556-1f47gvys 148 18 ) ) -RRB- cord-304556-1f47gvys 148 19 [ [ -LRB- cord-304556-1f47gvys 148 20 83 83 CD cord-304556-1f47gvys 148 21 , , , cord-304556-1f47gvys 148 22 84 84 CD cord-304556-1f47gvys 148 23 ] ] -RRB- cord-304556-1f47gvys 148 24 , , , cord-304556-1f47gvys 148 25 and and CC cord-304556-1f47gvys 148 26 elevated elevated JJ cord-304556-1f47gvys 148 27 levels level NNS cord-304556-1f47gvys 148 28 of of IN cord-304556-1f47gvys 148 29 HMGB1 HMGB1 NNP cord-304556-1f47gvys 148 30 both both CC cord-304556-1f47gvys 148 31 in in IN cord-304556-1f47gvys 148 32 the the DT cord-304556-1f47gvys 148 33 airways airway NNS cord-304556-1f47gvys 148 34 and and CC cord-304556-1f47gvys 148 35 peripheral peripheral JJ cord-304556-1f47gvys 148 36 blood blood NN cord-304556-1f47gvys 148 37 of of IN cord-304556-1f47gvys 148 38 patients patient NNS cord-304556-1f47gvys 148 39 with with IN cord-304556-1f47gvys 148 40 COPD COPD NNP cord-304556-1f47gvys 148 41 have have VBP cord-304556-1f47gvys 148 42 recently recently RB cord-304556-1f47gvys 148 43 been be VBN cord-304556-1f47gvys 148 44 reported report VBN cord-304556-1f47gvys 148 45 , , , cord-304556-1f47gvys 148 46 negatively negatively RB cord-304556-1f47gvys 148 47 correlating correlate VBG cord-304556-1f47gvys 148 48 with with IN cord-304556-1f47gvys 148 49 patient patient JJ cord-304556-1f47gvys 148 50 lung lung NN cord-304556-1f47gvys 148 51 function function NN cord-304556-1f47gvys 148 52 [ [ -LRB- cord-304556-1f47gvys 148 53 20 20 CD cord-304556-1f47gvys 148 54 , , , cord-304556-1f47gvys 148 55 85 85 CD cord-304556-1f47gvys 148 56 ] ] -RRB- cord-304556-1f47gvys 148 57 . . . cord-304556-1f47gvys 149 1 Since since IN cord-304556-1f47gvys 149 2 necrotic necrotic JJ cord-304556-1f47gvys 149 3 cells cell NNS cord-304556-1f47gvys 149 4 are be VBP cord-304556-1f47gvys 149 5 the the DT cord-304556-1f47gvys 149 6 main main JJ cord-304556-1f47gvys 149 7 source source NN cord-304556-1f47gvys 149 8 of of IN cord-304556-1f47gvys 149 9 extracellular extracellular JJ cord-304556-1f47gvys 149 10 HMGB1 HMGB1 NNP cord-304556-1f47gvys 149 11 , , , cord-304556-1f47gvys 149 12 a a DT cord-304556-1f47gvys 149 13 positive positive JJ cord-304556-1f47gvys 149 14 feedback feedback NN cord-304556-1f47gvys 149 15 loop loop NN cord-304556-1f47gvys 149 16 might may MD cord-304556-1f47gvys 149 17 exist exist VB cord-304556-1f47gvys 149 18 in in IN cord-304556-1f47gvys 149 19 COPD COPD NNP cord-304556-1f47gvys 149 20 where where WRB cord-304556-1f47gvys 149 21 apoptotic apoptotic JJ cord-304556-1f47gvys 149 22 cells cell NNS cord-304556-1f47gvys 149 23 undergo undergo VBP cord-304556-1f47gvys 149 24 secondary secondary JJ cord-304556-1f47gvys 149 25 necrosis necrosis NN cord-304556-1f47gvys 149 26 and and CC cord-304556-1f47gvys 149 27 release release VB cord-304556-1f47gvys 149 28 HMGB1 HMGB1 NNP cord-304556-1f47gvys 149 29 , , , cord-304556-1f47gvys 149 30 which which WDT cord-304556-1f47gvys 149 31 further further RB cord-304556-1f47gvys 149 32 impairs impair VBZ cord-304556-1f47gvys 149 33 the the DT cord-304556-1f47gvys 149 34 efferocytic efferocytic JJ cord-304556-1f47gvys 149 35 function function NN cord-304556-1f47gvys 149 36 of of IN cord-304556-1f47gvys 149 37 airway airway NN cord-304556-1f47gvys 149 38 macrophages macrophage NNS cord-304556-1f47gvys 149 39 . . . cord-304556-1f47gvys 150 1 This this DT cord-304556-1f47gvys 150 2 in in IN cord-304556-1f47gvys 150 3 turn turn NN cord-304556-1f47gvys 150 4 would would MD cord-304556-1f47gvys 150 5 lead lead VB cord-304556-1f47gvys 150 6 to to IN cord-304556-1f47gvys 150 7 accumulation accumulation NN cord-304556-1f47gvys 150 8 of of IN cord-304556-1f47gvys 150 9 greater great JJR cord-304556-1f47gvys 150 10 amounts amount NNS cord-304556-1f47gvys 150 11 of of IN cord-304556-1f47gvys 150 12 necrotic necrotic JJ cord-304556-1f47gvys 150 13 debris debris NN cord-304556-1f47gvys 150 14 and and CC cord-304556-1f47gvys 150 15 perpetuation perpetuation NN cord-304556-1f47gvys 150 16 of of IN cord-304556-1f47gvys 150 17 chronic chronic JJ cord-304556-1f47gvys 150 18 inflammation inflammation NN cord-304556-1f47gvys 150 19 . . . cord-304556-1f47gvys 151 1 Finally finally RB cord-304556-1f47gvys 151 2 , , , cord-304556-1f47gvys 151 3 engulfment engulfment NN cord-304556-1f47gvys 151 4 of of IN cord-304556-1f47gvys 151 5 apoptotic apoptotic JJ cord-304556-1f47gvys 151 6 cells cell NNS cord-304556-1f47gvys 151 7 by by IN cord-304556-1f47gvys 151 8 macrophages macrophage NNS cord-304556-1f47gvys 151 9 is be VBZ cord-304556-1f47gvys 151 10 also also RB cord-304556-1f47gvys 151 11 regulated regulate VBN cord-304556-1f47gvys 151 12 by by IN cord-304556-1f47gvys 151 13 the the DT cord-304556-1f47gvys 151 14 members member NNS cord-304556-1f47gvys 151 15 of of IN cord-304556-1f47gvys 151 16 the the DT cord-304556-1f47gvys 151 17 collectin collectin NN cord-304556-1f47gvys 151 18 family family NN cord-304556-1f47gvys 151 19 of of IN cord-304556-1f47gvys 151 20 C c NN cord-304556-1f47gvys 151 21 - - HYPH cord-304556-1f47gvys 151 22 type type NN cord-304556-1f47gvys 151 23 lectins lectin NNS cord-304556-1f47gvys 151 24 . . . cord-304556-1f47gvys 152 1 The the DT cord-304556-1f47gvys 152 2 levels level NNS cord-304556-1f47gvys 152 3 of of IN cord-304556-1f47gvys 152 4 mannose mannose NN cord-304556-1f47gvys 152 5 - - HYPH cord-304556-1f47gvys 152 6 binding bind VBG cord-304556-1f47gvys 152 7 lectin lectin NN cord-304556-1f47gvys 152 8 ( ( -LRB- cord-304556-1f47gvys 152 9 MBL MBL NNP cord-304556-1f47gvys 152 10 ) ) -RRB- cord-304556-1f47gvys 152 11 , , , cord-304556-1f47gvys 152 12 which which WDT cord-304556-1f47gvys 152 13 promotes promote VBZ cord-304556-1f47gvys 152 14 apoptotic apoptotic JJ cord-304556-1f47gvys 152 15 cell cell NN cord-304556-1f47gvys 152 16 uptake uptake NN cord-304556-1f47gvys 152 17 in in IN cord-304556-1f47gvys 152 18 vitro vitro FW cord-304556-1f47gvys 152 19 [ [ -LRB- cord-304556-1f47gvys 152 20 86 86 CD cord-304556-1f47gvys 152 21 ] ] -RRB- cord-304556-1f47gvys 152 22 , , , cord-304556-1f47gvys 152 23 are be VBP cord-304556-1f47gvys 152 24 reduced reduce VBN cord-304556-1f47gvys 152 25 in in IN cord-304556-1f47gvys 152 26 the the DT cord-304556-1f47gvys 152 27 airways airway NNS cord-304556-1f47gvys 152 28 of of IN cord-304556-1f47gvys 152 29 patients patient NNS cord-304556-1f47gvys 152 30 with with IN cord-304556-1f47gvys 152 31 COPD COPD NNP cord-304556-1f47gvys 152 32 and and CC cord-304556-1f47gvys 152 33 correlate correlate VB cord-304556-1f47gvys 152 34 with with IN cord-304556-1f47gvys 152 35 impaired impaired JJ cord-304556-1f47gvys 152 36 macrophage macrophage NN cord-304556-1f47gvys 152 37 efferocytosis efferocytosis NN cord-304556-1f47gvys 152 38 [ [ -LRB- cord-304556-1f47gvys 152 39 87 87 CD cord-304556-1f47gvys 152 40 , , , cord-304556-1f47gvys 152 41 88 88 CD cord-304556-1f47gvys 152 42 ] ] -RRB- cord-304556-1f47gvys 152 43 . . . cord-304556-1f47gvys 153 1 Surfactant surfactant NN cord-304556-1f47gvys 153 2 protein protein NN cord-304556-1f47gvys 153 3 A a NN cord-304556-1f47gvys 153 4 ( ( -LRB- cord-304556-1f47gvys 153 5 SP SP NNP cord-304556-1f47gvys 153 6 - - HYPH cord-304556-1f47gvys 153 7 A A NNP cord-304556-1f47gvys 153 8 ) ) -RRB- cord-304556-1f47gvys 153 9 and and CC cord-304556-1f47gvys 153 10 SP SP NNP cord-304556-1f47gvys 153 11 - - HYPH cord-304556-1f47gvys 153 12 D D NNP cord-304556-1f47gvys 153 13 , , , cord-304556-1f47gvys 153 14 on on IN cord-304556-1f47gvys 153 15 the the DT cord-304556-1f47gvys 153 16 other other JJ cord-304556-1f47gvys 153 17 hand hand NN cord-304556-1f47gvys 153 18 , , , cord-304556-1f47gvys 153 19 play play VB cord-304556-1f47gvys 153 20 a a DT cord-304556-1f47gvys 153 21 more more RBR cord-304556-1f47gvys 153 22 complex complex JJ cord-304556-1f47gvys 153 23 role role NN cord-304556-1f47gvys 153 24 in in IN cord-304556-1f47gvys 153 25 apoptotic apoptotic JJ cord-304556-1f47gvys 153 26 cell cell NN cord-304556-1f47gvys 153 27 recognition recognition NN cord-304556-1f47gvys 153 28 in in IN cord-304556-1f47gvys 153 29 the the DT cord-304556-1f47gvys 153 30 lung lung NN cord-304556-1f47gvys 153 31 . . . cord-304556-1f47gvys 154 1 While while IN cord-304556-1f47gvys 154 2 homeostatic homeostatic JJ cord-304556-1f47gvys 154 3 interaction interaction NN cord-304556-1f47gvys 154 4 of of IN cord-304556-1f47gvys 154 5 SP SP NNP cord-304556-1f47gvys 154 6 - - HYPH cord-304556-1f47gvys 154 7 A A NNP cord-304556-1f47gvys 154 8 or or CC cord-304556-1f47gvys 154 9 SP sp NN cord-304556-1f47gvys 154 10 - - HYPH cord-304556-1f47gvys 154 11 D D NNP cord-304556-1f47gvys 154 12 with with IN cord-304556-1f47gvys 154 13 signal signal JJ cord-304556-1f47gvys 154 14 inhibitory inhibitory JJ cord-304556-1f47gvys 154 15 regulatory regulatory JJ cord-304556-1f47gvys 154 16 protein protein NN cord-304556-1f47gvys 154 17 - - HYPH cord-304556-1f47gvys 154 18 α α NN cord-304556-1f47gvys 154 19 ( ( -LRB- cord-304556-1f47gvys 154 20 SIRPα SIRPα NNS cord-304556-1f47gvys 154 21 ) ) -RRB- cord-304556-1f47gvys 154 22 expressed express VBN cord-304556-1f47gvys 154 23 on on IN cord-304556-1f47gvys 154 24 airway airway NN cord-304556-1f47gvys 154 25 macrophages macrophage NNS cord-304556-1f47gvys 154 26 suppresses suppress VBZ cord-304556-1f47gvys 154 27 efferocytosis efferocytosis NNP cord-304556-1f47gvys 154 28 [ [ -LRB- cord-304556-1f47gvys 154 29 89 89 CD cord-304556-1f47gvys 154 30 ] ] -RRB- cord-304556-1f47gvys 154 31 , , , cord-304556-1f47gvys 154 32 opsonisation opsonisation NN cord-304556-1f47gvys 154 33 of of IN cord-304556-1f47gvys 154 34 apoptotic apoptotic JJ cord-304556-1f47gvys 154 35 cells cell NNS cord-304556-1f47gvys 154 36 by by IN cord-304556-1f47gvys 154 37 SP SP NNP cord-304556-1f47gvys 154 38 - - HYPH cord-304556-1f47gvys 154 39 A A NNP cord-304556-1f47gvys 154 40 or or CC cord-304556-1f47gvys 154 41 SP SP NNP cord-304556-1f47gvys 154 42 - - HYPH cord-304556-1f47gvys 154 43 D d NN cord-304556-1f47gvys 154 44 and and CC cord-304556-1f47gvys 154 45 interaction interaction NN cord-304556-1f47gvys 154 46 of of IN cord-304556-1f47gvys 154 47 this this DT cord-304556-1f47gvys 154 48 complex complex NN cord-304556-1f47gvys 154 49 with with IN cord-304556-1f47gvys 155 1 LRP-1 LRP-1 NNP cord-304556-1f47gvys 155 2 / / SYM cord-304556-1f47gvys 155 3 CD91 CD91 NNP cord-304556-1f47gvys 155 4 enhances enhance VBZ cord-304556-1f47gvys 155 5 apoptotic apoptotic JJ cord-304556-1f47gvys 155 6 cell cell NN cord-304556-1f47gvys 155 7 uptake uptake NN cord-304556-1f47gvys 155 8 [ [ -LRB- cord-304556-1f47gvys 155 9 29 29 CD cord-304556-1f47gvys 155 10 , , , cord-304556-1f47gvys 155 11 90 90 CD cord-304556-1f47gvys 155 12 ] ] -RRB- cord-304556-1f47gvys 155 13 . . . cord-304556-1f47gvys 156 1 The the DT cord-304556-1f47gvys 156 2 latter latter NN cord-304556-1f47gvys 156 3 seems seem VBZ cord-304556-1f47gvys 156 4 to to TO cord-304556-1f47gvys 156 5 play play VB cord-304556-1f47gvys 156 6 a a DT cord-304556-1f47gvys 156 7 more more RBR cord-304556-1f47gvys 156 8 prominent prominent JJ cord-304556-1f47gvys 156 9 role role NN cord-304556-1f47gvys 156 10 during during IN cord-304556-1f47gvys 156 11 chronic chronic JJ cord-304556-1f47gvys 156 12 lung lung NN cord-304556-1f47gvys 156 13 inflammation inflammation NN cord-304556-1f47gvys 156 14 as as IN cord-304556-1f47gvys 156 15 SP SP NNP cord-304556-1f47gvys 156 16 - - HYPH cord-304556-1f47gvys 156 17 D d JJ cord-304556-1f47gvys 156 18 levels level NNS cord-304556-1f47gvys 156 19 are be VBP cord-304556-1f47gvys 156 20 significantly significantly RB cord-304556-1f47gvys 156 21 reduced reduce VBN cord-304556-1f47gvys 156 22 in in IN cord-304556-1f47gvys 156 23 patients patient NNS cord-304556-1f47gvys 156 24 with with IN cord-304556-1f47gvys 156 25 COPD COPD NNP cord-304556-1f47gvys 156 26 [ [ -LRB- cord-304556-1f47gvys 156 27 28 28 CD cord-304556-1f47gvys 156 28 , , , cord-304556-1f47gvys 156 29 91 91 CD cord-304556-1f47gvys 156 30 ] ] -RRB- cord-304556-1f47gvys 156 31 , , , cord-304556-1f47gvys 156 32 potentially potentially RB cord-304556-1f47gvys 156 33 contributing contribute VBG cord-304556-1f47gvys 156 34 to to IN cord-304556-1f47gvys 156 35 efferocytosis efferocytosis NN cord-304556-1f47gvys 156 36 defects defect NNS cord-304556-1f47gvys 156 37 . . . cord-304556-1f47gvys 157 1 Alternatively alternatively RB cord-304556-1f47gvys 157 2 , , , cord-304556-1f47gvys 157 3 downregulation downregulation NN cord-304556-1f47gvys 157 4 of of IN cord-304556-1f47gvys 157 5 SP SP NNP cord-304556-1f47gvys 157 6 - - HYPH cord-304556-1f47gvys 157 7 D D NNP cord-304556-1f47gvys 157 8 might may MD cord-304556-1f47gvys 157 9 represent represent VB cord-304556-1f47gvys 157 10 a a DT cord-304556-1f47gvys 157 11 physiological physiological JJ cord-304556-1f47gvys 157 12 response response NN cord-304556-1f47gvys 157 13 of of IN cord-304556-1f47gvys 157 14 the the DT cord-304556-1f47gvys 157 15 lung lung NN cord-304556-1f47gvys 157 16 aimed aim VBN cord-304556-1f47gvys 157 17 at at IN cord-304556-1f47gvys 157 18 overcoming overcome VBG cord-304556-1f47gvys 157 19 SIRPα SIRPα NNS cord-304556-1f47gvys 157 20 - - HYPH cord-304556-1f47gvys 157 21 dependent dependent JJ cord-304556-1f47gvys 157 22 suppression suppression NN cord-304556-1f47gvys 157 23 of of IN cord-304556-1f47gvys 157 24 macrophage macrophage NN cord-304556-1f47gvys 157 25 efferocytic efferocytic JJ cord-304556-1f47gvys 157 26 function function NN cord-304556-1f47gvys 157 27 in in IN cord-304556-1f47gvys 157 28 the the DT cord-304556-1f47gvys 157 29 presence presence NN cord-304556-1f47gvys 157 30 of of IN cord-304556-1f47gvys 157 31 large large JJ cord-304556-1f47gvys 157 32 amounts amount NNS cord-304556-1f47gvys 157 33 of of IN cord-304556-1f47gvys 157 34 dead dead JJ cord-304556-1f47gvys 157 35 cells cell NNS cord-304556-1f47gvys 157 36 , , , cord-304556-1f47gvys 157 37 which which WDT cord-304556-1f47gvys 157 38 fail fail VBP cord-304556-1f47gvys 157 39 to to TO cord-304556-1f47gvys 157 40 efficiently efficiently RB cord-304556-1f47gvys 157 41 remove remove VB cord-304556-1f47gvys 157 42 apoptotic apoptotic JJ cord-304556-1f47gvys 157 43 cells cell NNS cord-304556-1f47gvys 157 44 from from IN cord-304556-1f47gvys 157 45 the the DT cord-304556-1f47gvys 157 46 COPD COPD NNP cord-304556-1f47gvys 157 47 airways airway NNS cord-304556-1f47gvys 157 48 due due IN cord-304556-1f47gvys 157 49 to to IN cord-304556-1f47gvys 157 50 other other JJ cord-304556-1f47gvys 157 51 phagocytosis phagocytosis NN cord-304556-1f47gvys 157 52 defects defect NNS cord-304556-1f47gvys 157 53 . . . cord-304556-1f47gvys 158 1 Asthma asthma NN cord-304556-1f47gvys 158 2 is be VBZ cord-304556-1f47gvys 158 3 an an DT cord-304556-1f47gvys 158 4 obstructive obstructive JJ cord-304556-1f47gvys 158 5 airway airway NN cord-304556-1f47gvys 158 6 disease disease NN cord-304556-1f47gvys 158 7 characterised characterise VBN cord-304556-1f47gvys 158 8 by by IN cord-304556-1f47gvys 158 9 hyper hyper NN cord-304556-1f47gvys 158 10 - - NN cord-304556-1f47gvys 158 11 responsiveness responsiveness NN cord-304556-1f47gvys 158 12 and and CC cord-304556-1f47gvys 158 13 chronic chronic JJ cord-304556-1f47gvys 158 14 inflammation inflammation NN cord-304556-1f47gvys 158 15 of of IN cord-304556-1f47gvys 158 16 the the DT cord-304556-1f47gvys 158 17 respiratory respiratory JJ cord-304556-1f47gvys 158 18 tract tract NN cord-304556-1f47gvys 158 19 . . . cord-304556-1f47gvys 159 1 While while IN cord-304556-1f47gvys 159 2 neutrophils neutrophil NNS cord-304556-1f47gvys 159 3 are be VBP cord-304556-1f47gvys 159 4 a a DT cord-304556-1f47gvys 159 5 predominant predominant JJ cord-304556-1f47gvys 159 6 cell cell NN cord-304556-1f47gvys 159 7 type type NN cord-304556-1f47gvys 159 8 in in IN cord-304556-1f47gvys 159 9 the the DT cord-304556-1f47gvys 159 10 lungs lung NNS cord-304556-1f47gvys 159 11 of of IN cord-304556-1f47gvys 159 12 COPD COPD NNP cord-304556-1f47gvys 159 13 patients patient NNS cord-304556-1f47gvys 159 14 , , , cord-304556-1f47gvys 159 15 asthma asthma NN cord-304556-1f47gvys 159 16 represents represent VBZ cord-304556-1f47gvys 159 17 eosinophildominant eosinophildominant JJ cord-304556-1f47gvys 159 18 airway airway NN cord-304556-1f47gvys 159 19 inflammation inflammation NN cord-304556-1f47gvys 159 20 . . . cord-304556-1f47gvys 160 1 Initial initial JJ cord-304556-1f47gvys 160 2 priming priming NN cord-304556-1f47gvys 160 3 of of IN cord-304556-1f47gvys 160 4 the the DT cord-304556-1f47gvys 160 5 adaptive adaptive JJ cord-304556-1f47gvys 160 6 immune immune JJ cord-304556-1f47gvys 160 7 system system NN cord-304556-1f47gvys 160 8 by by IN cord-304556-1f47gvys 160 9 airway airway NN cord-304556-1f47gvys 160 10 allergens allergen NNS cord-304556-1f47gvys 160 11 leads lead VBZ cord-304556-1f47gvys 160 12 to to IN cord-304556-1f47gvys 160 13 the the DT cord-304556-1f47gvys 160 14 activation activation NN cord-304556-1f47gvys 160 15 of of IN cord-304556-1f47gvys 160 16 tissue tissue NN cord-304556-1f47gvys 160 17 - - HYPH cord-304556-1f47gvys 160 18 resident resident NN cord-304556-1f47gvys 160 19 mast mast NN cord-304556-1f47gvys 160 20 cells cell NNS cord-304556-1f47gvys 160 21 , , , cord-304556-1f47gvys 160 22 which which WDT cord-304556-1f47gvys 160 23 release release VBP cord-304556-1f47gvys 160 24 a a DT cord-304556-1f47gvys 160 25 broad broad JJ cord-304556-1f47gvys 160 26 array array NN cord-304556-1f47gvys 160 27 of of IN cord-304556-1f47gvys 160 28 inflammatory inflammatory JJ cord-304556-1f47gvys 160 29 mediators mediator NNS cord-304556-1f47gvys 160 30 promoting promote VBG cord-304556-1f47gvys 160 31 migration migration NN cord-304556-1f47gvys 160 32 of of IN cord-304556-1f47gvys 160 33 eosinophils eosinophil NNS cord-304556-1f47gvys 160 34 into into IN cord-304556-1f47gvys 160 35 the the DT cord-304556-1f47gvys 160 36 airways airway NNS cord-304556-1f47gvys 160 37 [ [ -LRB- cord-304556-1f47gvys 160 38 92 92 CD cord-304556-1f47gvys 160 39 ] ] -RRB- cord-304556-1f47gvys 160 40 . . . cord-304556-1f47gvys 161 1 Products product NNS cord-304556-1f47gvys 161 2 of of IN cord-304556-1f47gvys 161 3 eosinophil eosinophil JJ cord-304556-1f47gvys 161 4 degranulation degranulation NN cord-304556-1f47gvys 161 5 , , , cord-304556-1f47gvys 161 6 including include VBG cord-304556-1f47gvys 161 7 major major JJ cord-304556-1f47gvys 161 8 basic basic JJ cord-304556-1f47gvys 161 9 protein protein NN cord-304556-1f47gvys 161 10 , , , cord-304556-1f47gvys 161 11 eosinophil eosinophil JJ cord-304556-1f47gvys 161 12 cationic cationic JJ cord-304556-1f47gvys 161 13 protein protein NN cord-304556-1f47gvys 161 14 and and CC cord-304556-1f47gvys 161 15 reactive reactive JJ cord-304556-1f47gvys 161 16 oxygen oxygen NN cord-304556-1f47gvys 161 17 species specie NNS cord-304556-1f47gvys 161 18 , , , cord-304556-1f47gvys 161 19 are be VBP cord-304556-1f47gvys 161 20 cytotoxic cytotoxic JJ cord-304556-1f47gvys 161 21 to to IN cord-304556-1f47gvys 161 22 epithelial epithelial JJ cord-304556-1f47gvys 161 23 cells cell NNS cord-304556-1f47gvys 161 24 and and CC cord-304556-1f47gvys 161 25 cause cause VB cord-304556-1f47gvys 161 26 airway airway NN cord-304556-1f47gvys 161 27 damage damage NN cord-304556-1f47gvys 161 28 and and CC cord-304556-1f47gvys 161 29 tissue tissue NN cord-304556-1f47gvys 161 30 remodelling remodelling NN cord-304556-1f47gvys 161 31 . . . cord-304556-1f47gvys 162 1 Indeed indeed RB cord-304556-1f47gvys 162 2 , , , cord-304556-1f47gvys 162 3 increased increase VBN cord-304556-1f47gvys 162 4 numbers number NNS cord-304556-1f47gvys 162 5 of of IN cord-304556-1f47gvys 162 6 apoptotic apoptotic JJ cord-304556-1f47gvys 162 7 epithelial epithelial JJ cord-304556-1f47gvys 162 8 cells cell NNS cord-304556-1f47gvys 162 9 have have VBP cord-304556-1f47gvys 162 10 been be VBN cord-304556-1f47gvys 162 11 detected detect VBN cord-304556-1f47gvys 162 12 in in IN cord-304556-1f47gvys 162 13 the the DT cord-304556-1f47gvys 162 14 lungs lung NNS cord-304556-1f47gvys 162 15 of of IN cord-304556-1f47gvys 162 16 patients patient NNS cord-304556-1f47gvys 162 17 with with IN cord-304556-1f47gvys 162 18 asthma asthma NN cord-304556-1f47gvys 162 19 compared compare VBN cord-304556-1f47gvys 162 20 to to IN cord-304556-1f47gvys 162 21 healthy healthy JJ cord-304556-1f47gvys 162 22 individuals individual NNS cord-304556-1f47gvys 162 23 [ [ -LRB- cord-304556-1f47gvys 162 24 93 93 CD cord-304556-1f47gvys 162 25 ] ] -RRB- cord-304556-1f47gvys 162 26 . . . cord-304556-1f47gvys 163 1 Apoptosis apoptosis NN cord-304556-1f47gvys 163 2 and and CC cord-304556-1f47gvys 163 3 subsequent subsequent JJ cord-304556-1f47gvys 163 4 uptake uptake NN cord-304556-1f47gvys 163 5 by by IN cord-304556-1f47gvys 163 6 phagocytes phagocyte NNS cord-304556-1f47gvys 163 7 appear appear VBP cord-304556-1f47gvys 163 8 to to TO cord-304556-1f47gvys 163 9 be be VB cord-304556-1f47gvys 163 10 a a DT cord-304556-1f47gvys 163 11 predominant predominant JJ cord-304556-1f47gvys 163 12 mechanism mechanism NN cord-304556-1f47gvys 163 13 of of IN cord-304556-1f47gvys 163 14 eosinophil eosinophil JJ cord-304556-1f47gvys 163 15 removal removal NN cord-304556-1f47gvys 163 16 from from IN cord-304556-1f47gvys 163 17 the the DT cord-304556-1f47gvys 163 18 airways airways NNPS cord-304556-1f47gvys 163 19 [ [ -LRB- cord-304556-1f47gvys 163 20 94 94 CD cord-304556-1f47gvys 163 21 , , , cord-304556-1f47gvys 163 22 95 95 CD cord-304556-1f47gvys 163 23 ] ] -RRB- cord-304556-1f47gvys 163 24 , , , cord-304556-1f47gvys 163 25 and and CC cord-304556-1f47gvys 163 26 glucocorticoids glucocorticoid NNS cord-304556-1f47gvys 163 27 , , , cord-304556-1f47gvys 163 28 which which WDT cord-304556-1f47gvys 163 29 are be VBP cord-304556-1f47gvys 163 30 commonly commonly RB cord-304556-1f47gvys 163 31 used use VBN cord-304556-1f47gvys 163 32 to to TO cord-304556-1f47gvys 163 33 control control VB cord-304556-1f47gvys 163 34 inflammation inflammation NN cord-304556-1f47gvys 163 35 in in IN cord-304556-1f47gvys 163 36 asthma asthma NN cord-304556-1f47gvys 163 37 , , , cord-304556-1f47gvys 163 38 induce induce VB cord-304556-1f47gvys 163 39 eosinophil eosinophil JJ cord-304556-1f47gvys 163 40 apoptosis apoptosis NN cord-304556-1f47gvys 163 41 [ [ -LRB- cord-304556-1f47gvys 163 42 96 96 CD cord-304556-1f47gvys 163 43 ] ] -RRB- cord-304556-1f47gvys 163 44 . . . cord-304556-1f47gvys 164 1 These these DT cord-304556-1f47gvys 164 2 observations observation NNS cord-304556-1f47gvys 164 3 indicate indicate VBP cord-304556-1f47gvys 164 4 that that IN cord-304556-1f47gvys 164 5 high high JJ cord-304556-1f47gvys 164 6 efficiency efficiency NN cord-304556-1f47gvys 164 7 of of IN cord-304556-1f47gvys 164 8 the the DT cord-304556-1f47gvys 164 9 phagocytic phagocytic JJ cord-304556-1f47gvys 164 10 system system NN cord-304556-1f47gvys 164 11 is be VBZ cord-304556-1f47gvys 164 12 required require VBN cord-304556-1f47gvys 164 13 for for IN cord-304556-1f47gvys 164 14 removal removal NN cord-304556-1f47gvys 164 15 of of IN cord-304556-1f47gvys 164 16 large large JJ cord-304556-1f47gvys 164 17 quantities quantity NNS cord-304556-1f47gvys 164 18 of of IN cord-304556-1f47gvys 164 19 apoptotic apoptotic JJ cord-304556-1f47gvys 164 20 eosinophils eosinophil NNS cord-304556-1f47gvys 164 21 and and CC cord-304556-1f47gvys 164 22 bronchial bronchial JJ cord-304556-1f47gvys 164 23 epithelial epithelial JJ cord-304556-1f47gvys 164 24 cells cell NNS cord-304556-1f47gvys 164 25 from from IN cord-304556-1f47gvys 164 26 the the DT cord-304556-1f47gvys 164 27 airways airway NNS cord-304556-1f47gvys 164 28 of of IN cord-304556-1f47gvys 164 29 patients patient NNS cord-304556-1f47gvys 164 30 with with IN cord-304556-1f47gvys 164 31 asthma asthma NN cord-304556-1f47gvys 164 32 and and CC cord-304556-1f47gvys 164 33 raise raise VB cord-304556-1f47gvys 164 34 the the DT cord-304556-1f47gvys 164 35 possibility possibility NN cord-304556-1f47gvys 164 36 that that IN cord-304556-1f47gvys 164 37 defects defect NNS cord-304556-1f47gvys 164 38 in in IN cord-304556-1f47gvys 164 39 efferocytosis efferocytosis NN cord-304556-1f47gvys 164 40 might may MD cord-304556-1f47gvys 164 41 prevent prevent VB cord-304556-1f47gvys 164 42 resolution resolution NN cord-304556-1f47gvys 164 43 of of IN cord-304556-1f47gvys 164 44 lung lung NN cord-304556-1f47gvys 164 45 inflammation inflammation NN cord-304556-1f47gvys 164 46 . . . cord-304556-1f47gvys 165 1 Initial initial JJ cord-304556-1f47gvys 165 2 studies study NNS cord-304556-1f47gvys 165 3 by by IN cord-304556-1f47gvys 165 4 Hyunh Hyunh NNP cord-304556-1f47gvys 165 5 et et NNP cord-304556-1f47gvys 165 6 al al NNP cord-304556-1f47gvys 165 7 . . . cord-304556-1f47gvys 166 1 demonstrate demonstrate VB cord-304556-1f47gvys 166 2 that that IN cord-304556-1f47gvys 166 3 airway airway NN cord-304556-1f47gvys 166 4 macrophages macrophage NNS cord-304556-1f47gvys 166 5 from from IN cord-304556-1f47gvys 166 6 patients patient NNS cord-304556-1f47gvys 166 7 with with IN cord-304556-1f47gvys 166 8 severe severe JJ cord-304556-1f47gvys 166 9 asthma asthma NN cord-304556-1f47gvys 166 10 contain contain VBP cord-304556-1f47gvys 166 11 reduced reduce VBN cord-304556-1f47gvys 166 12 numbers number NNS cord-304556-1f47gvys 166 13 of of IN cord-304556-1f47gvys 166 14 phagocytic phagocytic JJ cord-304556-1f47gvys 166 15 bodies body NNS cord-304556-1f47gvys 166 16 compared compare VBN cord-304556-1f47gvys 166 17 to to IN cord-304556-1f47gvys 166 18 healthy healthy JJ cord-304556-1f47gvys 166 19 donors donor NNS cord-304556-1f47gvys 166 20 and and CC cord-304556-1f47gvys 166 21 patients patient NNS cord-304556-1f47gvys 166 22 with with IN cord-304556-1f47gvys 166 23 mild mild JJ cord-304556-1f47gvys 166 24 / / SYM cord-304556-1f47gvys 166 25 moderate moderate JJ cord-304556-1f47gvys 166 26 asthma asthma NN cord-304556-1f47gvys 166 27 and and CC cord-304556-1f47gvys 166 28 are be VBP cord-304556-1f47gvys 166 29 defective defective JJ cord-304556-1f47gvys 166 30 in in IN cord-304556-1f47gvys 166 31 phagocytosing phagocytose VBG cord-304556-1f47gvys 166 32 apoptotic apoptotic JJ cord-304556-1f47gvys 166 33 Jurkat Jurkat NNP cord-304556-1f47gvys 166 34 T T NNP cord-304556-1f47gvys 166 35 cells cell NNS cord-304556-1f47gvys 166 36 in in IN cord-304556-1f47gvys 166 37 vitro vitro FW cord-304556-1f47gvys 166 38 [ [ -LRB- cord-304556-1f47gvys 166 39 97 97 CD cord-304556-1f47gvys 166 40 ] ] -RRB- cord-304556-1f47gvys 166 41 . . . cord-304556-1f47gvys 167 1 Failure failure NN cord-304556-1f47gvys 167 2 of of IN cord-304556-1f47gvys 167 3 airway airway NN cord-304556-1f47gvys 167 4 macrophages macrophage NNS cord-304556-1f47gvys 167 5 from from IN cord-304556-1f47gvys 167 6 patients patient NNS cord-304556-1f47gvys 167 7 with with IN cord-304556-1f47gvys 167 8 severe severe JJ cord-304556-1f47gvys 167 9 asthma asthma NN cord-304556-1f47gvys 167 10 to to TO cord-304556-1f47gvys 167 11 efficiently efficiently RB cord-304556-1f47gvys 167 12 clear clear VB cord-304556-1f47gvys 167 13 apoptotic apoptotic JJ cord-304556-1f47gvys 167 14 cells cell NNS cord-304556-1f47gvys 167 15 is be VBZ cord-304556-1f47gvys 167 16 associated associate VBN cord-304556-1f47gvys 167 17 with with IN cord-304556-1f47gvys 167 18 reduced reduced JJ cord-304556-1f47gvys 167 19 production production NN cord-304556-1f47gvys 167 20 of of IN cord-304556-1f47gvys 167 21 anti anti JJ cord-304556-1f47gvys 167 22 - - JJ cord-304556-1f47gvys 167 23 inflammatory inflammatory JJ cord-304556-1f47gvys 167 24 eicosanoids eicosanoid NNS cord-304556-1f47gvys 167 25 [ [ -LRB- cord-304556-1f47gvys 167 26 97 97 CD cord-304556-1f47gvys 167 27 ] ] -RRB- cord-304556-1f47gvys 167 28 , , , cord-304556-1f47gvys 167 29 suggesting suggest VBG cord-304556-1f47gvys 167 30 that that IN cord-304556-1f47gvys 167 31 defects defect NNS cord-304556-1f47gvys 167 32 in in IN cord-304556-1f47gvys 167 33 efferocytosis efferocytosis NN cord-304556-1f47gvys 167 34 might may MD cord-304556-1f47gvys 167 35 contribute contribute VB cord-304556-1f47gvys 167 36 to to IN cord-304556-1f47gvys 167 37 perpetuation perpetuation NN cord-304556-1f47gvys 167 38 of of IN cord-304556-1f47gvys 167 39 inflammation inflammation NN cord-304556-1f47gvys 167 40 in in IN cord-304556-1f47gvys 167 41 asthma asthma NN cord-304556-1f47gvys 167 42 , , , cord-304556-1f47gvys 167 43 not not RB cord-304556-1f47gvys 167 44 only only RB cord-304556-1f47gvys 167 45 through through IN cord-304556-1f47gvys 167 46 secondary secondary JJ cord-304556-1f47gvys 167 47 necrosis necrosis NN cord-304556-1f47gvys 167 48 of of IN cord-304556-1f47gvys 167 49 apoptotic apoptotic JJ cord-304556-1f47gvys 167 50 cells cell NNS cord-304556-1f47gvys 167 51 , , , cord-304556-1f47gvys 167 52 but but CC cord-304556-1f47gvys 167 53 also also RB cord-304556-1f47gvys 167 54 by by IN cord-304556-1f47gvys 167 55 reduced reduce VBN cord-304556-1f47gvys 167 56 release release NN cord-304556-1f47gvys 167 57 of of IN cord-304556-1f47gvys 167 58 regulatory regulatory JJ cord-304556-1f47gvys 167 59 mediators mediator NNS cord-304556-1f47gvys 167 60 that that WDT cord-304556-1f47gvys 167 61 are be VBP cord-304556-1f47gvys 167 62 normally normally RB cord-304556-1f47gvys 167 63 produced produce VBN cord-304556-1f47gvys 167 64 upon upon IN cord-304556-1f47gvys 167 65 recognition recognition NN cord-304556-1f47gvys 167 66 of of IN cord-304556-1f47gvys 167 67 apoptotic apoptotic JJ cord-304556-1f47gvys 167 68 cells cell NNS cord-304556-1f47gvys 167 69 by by IN cord-304556-1f47gvys 167 70 airway airway NN cord-304556-1f47gvys 167 71 macrophages macrophage NNS cord-304556-1f47gvys 167 72 . . . cord-304556-1f47gvys 168 1 More more RBR cord-304556-1f47gvys 168 2 recently recently RB cord-304556-1f47gvys 168 3 , , , cord-304556-1f47gvys 168 4 it -PRON- PRP cord-304556-1f47gvys 168 5 has have VBZ cord-304556-1f47gvys 168 6 been be VBN cord-304556-1f47gvys 168 7 shown show VBN cord-304556-1f47gvys 168 8 that that IN cord-304556-1f47gvys 168 9 efferocytosis efferocytosis NN cord-304556-1f47gvys 168 10 of of IN cord-304556-1f47gvys 168 11 apoptotic apoptotic JJ cord-304556-1f47gvys 168 12 bronchial bronchial JJ cord-304556-1f47gvys 168 13 epithelial epithelial JJ cord-304556-1f47gvys 168 14 cells cell NNS cord-304556-1f47gvys 168 15 by by IN cord-304556-1f47gvys 168 16 airway airway NN cord-304556-1f47gvys 168 17 macrophages macrophage NNS cord-304556-1f47gvys 168 18 isolated isolate VBN cord-304556-1f47gvys 168 19 from from IN cord-304556-1f47gvys 168 20 induced induce VBN cord-304556-1f47gvys 168 21 sputum sputum NN cord-304556-1f47gvys 168 22 of of IN cord-304556-1f47gvys 168 23 patients patient NNS cord-304556-1f47gvys 168 24 with with IN cord-304556-1f47gvys 168 25 non non JJ cord-304556-1f47gvys 168 26 - - JJ cord-304556-1f47gvys 168 27 eosinophilic eosinophilic JJ cord-304556-1f47gvys 168 28 asthma asthma NN cord-304556-1f47gvys 168 29 is be VBZ cord-304556-1f47gvys 168 30 significantly significantly RB cord-304556-1f47gvys 168 31 reduced reduce VBN cord-304556-1f47gvys 168 32 compared compare VBN cord-304556-1f47gvys 168 33 with with IN cord-304556-1f47gvys 168 34 patients patient NNS cord-304556-1f47gvys 168 35 with with IN cord-304556-1f47gvys 168 36 eosinophilic eosinophilic JJ cord-304556-1f47gvys 168 37 asthma asthma NN cord-304556-1f47gvys 168 38 , , , cord-304556-1f47gvys 168 39 and and CC cord-304556-1f47gvys 168 40 the the DT cord-304556-1f47gvys 168 41 degree degree NN cord-304556-1f47gvys 168 42 of of IN cord-304556-1f47gvys 168 43 uptake uptake NN cord-304556-1f47gvys 168 44 impairment impairment NN cord-304556-1f47gvys 168 45 is be VBZ cord-304556-1f47gvys 168 46 comparable comparable JJ cord-304556-1f47gvys 168 47 to to IN cord-304556-1f47gvys 168 48 that that DT cord-304556-1f47gvys 168 49 observed observe VBN cord-304556-1f47gvys 168 50 in in IN cord-304556-1f47gvys 168 51 COPD COPD NNP cord-304556-1f47gvys 168 52 [ [ -LRB- cord-304556-1f47gvys 168 53 98 98 CD cord-304556-1f47gvys 168 54 ] ] -RRB- cord-304556-1f47gvys 168 55 . . . cord-304556-1f47gvys 169 1 This this DT cord-304556-1f47gvys 169 2 observation observation NN cord-304556-1f47gvys 169 3 might may MD cord-304556-1f47gvys 169 4 partly partly RB cord-304556-1f47gvys 169 5 explain explain VB cord-304556-1f47gvys 169 6 the the DT cord-304556-1f47gvys 169 7 persistent persistent JJ cord-304556-1f47gvys 169 8 neutrophilia neutrophilia NNS cord-304556-1f47gvys 169 9 and and CC cord-304556-1f47gvys 169 10 aberrant aberrant JJ cord-304556-1f47gvys 169 11 innate innate JJ cord-304556-1f47gvys 169 12 immune immune JJ cord-304556-1f47gvys 169 13 responses response NNS cord-304556-1f47gvys 169 14 in in IN cord-304556-1f47gvys 169 15 this this DT cord-304556-1f47gvys 169 16 subgroup subgroup NN cord-304556-1f47gvys 169 17 of of IN cord-304556-1f47gvys 169 18 patients patient NNS cord-304556-1f47gvys 169 19 [ [ -LRB- cord-304556-1f47gvys 169 20 99 99 CD cord-304556-1f47gvys 169 21 ] ] -RRB- cord-304556-1f47gvys 169 22 . . . cord-304556-1f47gvys 170 1 Efferocytosis efferocytosis NN cord-304556-1f47gvys 170 2 defects defect NNS cord-304556-1f47gvys 170 3 in in IN cord-304556-1f47gvys 170 4 asthma asthma NN cord-304556-1f47gvys 170 5 are be VBP cord-304556-1f47gvys 170 6 associated associate VBN cord-304556-1f47gvys 170 7 not not RB cord-304556-1f47gvys 170 8 only only RB cord-304556-1f47gvys 170 9 with with IN cord-304556-1f47gvys 170 10 the the DT cord-304556-1f47gvys 170 11 subtype subtype NN cord-304556-1f47gvys 170 12 of of IN cord-304556-1f47gvys 170 13 airway airway JJ cord-304556-1f47gvys 170 14 inflammation inflammation NN cord-304556-1f47gvys 170 15 but but CC cord-304556-1f47gvys 170 16 also also RB cord-304556-1f47gvys 170 17 with with IN cord-304556-1f47gvys 170 18 the the DT cord-304556-1f47gvys 170 19 BMI BMI NNP cord-304556-1f47gvys 170 20 index index NN cord-304556-1f47gvys 170 21 : : : cord-304556-1f47gvys 170 22 airway airway NN cord-304556-1f47gvys 170 23 macrophages macrophage NNS cord-304556-1f47gvys 170 24 from from IN cord-304556-1f47gvys 170 25 obese obese JJ cord-304556-1f47gvys 170 26 patients patient NNS cord-304556-1f47gvys 170 27 with with IN cord-304556-1f47gvys 170 28 asthma asthma NN cord-304556-1f47gvys 170 29 , , , cord-304556-1f47gvys 170 30 which which WDT cord-304556-1f47gvys 170 31 typically typically RB cord-304556-1f47gvys 170 32 suffer suffer VBP cord-304556-1f47gvys 170 33 from from IN cord-304556-1f47gvys 170 34 more more RBR cord-304556-1f47gvys 170 35 severe severe JJ cord-304556-1f47gvys 170 36 disease disease NN cord-304556-1f47gvys 170 37 symptoms symptom NNS cord-304556-1f47gvys 170 38 [ [ -LRB- cord-304556-1f47gvys 170 39 100 100 CD cord-304556-1f47gvys 170 40 ] ] -RRB- cord-304556-1f47gvys 170 41 , , , cord-304556-1f47gvys 170 42 are be VBP cord-304556-1f47gvys 170 43 characterised characterise VBN cord-304556-1f47gvys 170 44 by by IN cord-304556-1f47gvys 170 45 significantly significantly RB cord-304556-1f47gvys 170 46 reduced reduce VBN cord-304556-1f47gvys 170 47 numbers number NNS cord-304556-1f47gvys 170 48 of of IN cord-304556-1f47gvys 170 49 phagocytic phagocytic JJ cord-304556-1f47gvys 170 50 bodies body NNS cord-304556-1f47gvys 170 51 compared compare VBN cord-304556-1f47gvys 170 52 to to IN cord-304556-1f47gvys 170 53 non non JJ cord-304556-1f47gvys 170 54 - - JJ cord-304556-1f47gvys 170 55 obese obese JJ cord-304556-1f47gvys 170 56 asthmatics asthmatic NNS cord-304556-1f47gvys 170 57 [ [ -LRB- cord-304556-1f47gvys 170 58 101 101 CD cord-304556-1f47gvys 170 59 ] ] -RRB- cord-304556-1f47gvys 170 60 . . . cord-304556-1f47gvys 171 1 Notably notably RB cord-304556-1f47gvys 171 2 , , , cord-304556-1f47gvys 171 3 defective defective JJ cord-304556-1f47gvys 171 4 efferocytic efferocytic JJ cord-304556-1f47gvys 171 5 function function NN cord-304556-1f47gvys 171 6 in in IN cord-304556-1f47gvys 171 7 obese obese JJ cord-304556-1f47gvys 171 8 asthmatics asthmatic NNS cord-304556-1f47gvys 171 9 is be VBZ cord-304556-1f47gvys 171 10 not not RB cord-304556-1f47gvys 171 11 restricted restrict VBN cord-304556-1f47gvys 171 12 to to IN cord-304556-1f47gvys 171 13 the the DT cord-304556-1f47gvys 171 14 site site NN cord-304556-1f47gvys 171 15 of of IN cord-304556-1f47gvys 171 16 inflammation inflammation NN cord-304556-1f47gvys 171 17 as as IN cord-304556-1f47gvys 171 18 decreased decrease VBN cord-304556-1f47gvys 171 19 uptake uptake NN cord-304556-1f47gvys 171 20 of of IN cord-304556-1f47gvys 171 21 beads bead NNS cord-304556-1f47gvys 171 22 mimicking mimic VBG cord-304556-1f47gvys 171 23 apoptotic apoptotic JJ cord-304556-1f47gvys 171 24 cells cell NNS cord-304556-1f47gvys 171 25 is be VBZ cord-304556-1f47gvys 171 26 also also RB cord-304556-1f47gvys 171 27 observed observe VBN cord-304556-1f47gvys 171 28 in in IN cord-304556-1f47gvys 171 29 peripheral peripheral JJ cord-304556-1f47gvys 171 30 blood blood NN cord-304556-1f47gvys 171 31 monocytes monocyte NNS cord-304556-1f47gvys 171 32 isolated isolate VBN cord-304556-1f47gvys 171 33 from from IN cord-304556-1f47gvys 171 34 these these DT cord-304556-1f47gvys 171 35 patients patient NNS cord-304556-1f47gvys 171 36 , , , cord-304556-1f47gvys 171 37 correlating correlate VBG cord-304556-1f47gvys 171 38 with with IN cord-304556-1f47gvys 171 39 reduced reduce VBN cord-304556-1f47gvys 171 40 glucocorticoid glucocorticoid NN cord-304556-1f47gvys 171 41 responsiveness responsiveness NN cord-304556-1f47gvys 171 42 [ [ -LRB- cord-304556-1f47gvys 171 43 101 101 CD cord-304556-1f47gvys 171 44 ] ] -RRB- cord-304556-1f47gvys 171 45 . . . cord-304556-1f47gvys 172 1 While while IN cord-304556-1f47gvys 172 2 these these DT cord-304556-1f47gvys 172 3 reports report NNS cord-304556-1f47gvys 172 4 provide provide VBP cord-304556-1f47gvys 172 5 clear clear JJ cord-304556-1f47gvys 172 6 evidence evidence NN cord-304556-1f47gvys 172 7 that that IN cord-304556-1f47gvys 172 8 removal removal NN cord-304556-1f47gvys 172 9 of of IN cord-304556-1f47gvys 172 10 apoptotic apoptotic JJ cord-304556-1f47gvys 172 11 cells cell NNS cord-304556-1f47gvys 172 12 is be VBZ cord-304556-1f47gvys 172 13 defective defective JJ cord-304556-1f47gvys 172 14 in in IN cord-304556-1f47gvys 172 15 asthma asthma NN cord-304556-1f47gvys 172 16 , , , cord-304556-1f47gvys 172 17 in in IN cord-304556-1f47gvys 172 18 particular particular JJ cord-304556-1f47gvys 172 19 in in IN cord-304556-1f47gvys 172 20 certain certain JJ cord-304556-1f47gvys 172 21 disease disease NN cord-304556-1f47gvys 172 22 subtypes subtype NNS cord-304556-1f47gvys 172 23 , , , cord-304556-1f47gvys 172 24 additional additional JJ cord-304556-1f47gvys 172 25 studies study NNS cord-304556-1f47gvys 172 26 are be VBP cord-304556-1f47gvys 172 27 needed need VBN cord-304556-1f47gvys 172 28 to to TO cord-304556-1f47gvys 172 29 characterise characterise VB cord-304556-1f47gvys 172 30 the the DT cord-304556-1f47gvys 172 31 molecular molecular JJ cord-304556-1f47gvys 172 32 mechanisms mechanism NNS cord-304556-1f47gvys 172 33 underlying underlie VBG cord-304556-1f47gvys 172 34 the the DT cord-304556-1f47gvys 172 35 observed observed JJ cord-304556-1f47gvys 172 36 defects defect NNS cord-304556-1f47gvys 172 37 . . . cord-304556-1f47gvys 173 1 Even even RB cord-304556-1f47gvys 173 2 though though IN cord-304556-1f47gvys 173 3 potential potential JJ cord-304556-1f47gvys 173 4 changes change NNS cord-304556-1f47gvys 173 5 in in IN cord-304556-1f47gvys 173 6 expression expression NN cord-304556-1f47gvys 173 7 and and CC cord-304556-1f47gvys 173 8 function function NN cord-304556-1f47gvys 173 9 of of IN cord-304556-1f47gvys 173 10 receptors receptor NNS cord-304556-1f47gvys 173 11 recognising recognise VBG cord-304556-1f47gvys 173 12 apoptotic apoptotic JJ cord-304556-1f47gvys 173 13 cells cell NNS cord-304556-1f47gvys 173 14 on on IN cord-304556-1f47gvys 173 15 airway airway NN cord-304556-1f47gvys 173 16 macrophages macrophage NNS cord-304556-1f47gvys 173 17 have have VBP cord-304556-1f47gvys 173 18 not not RB cord-304556-1f47gvys 173 19 been be VBN cord-304556-1f47gvys 173 20 formally formally RB cord-304556-1f47gvys 173 21 studied study VBN cord-304556-1f47gvys 173 22 in in IN cord-304556-1f47gvys 173 23 asthma asthma NN cord-304556-1f47gvys 173 24 , , , cord-304556-1f47gvys 173 25 it -PRON- PRP cord-304556-1f47gvys 173 26 is be VBZ cord-304556-1f47gvys 173 27 important important JJ cord-304556-1f47gvys 173 28 to to TO cord-304556-1f47gvys 173 29 note note VB cord-304556-1f47gvys 173 30 that that IN cord-304556-1f47gvys 173 31 the the DT cord-304556-1f47gvys 173 32 TIM TIM NNP cord-304556-1f47gvys 173 33 receptor receptor NN cord-304556-1f47gvys 173 34 family family NN cord-304556-1f47gvys 173 35 member member NN cord-304556-1f47gvys 173 36 TIM-1 TIM-1 NNP cord-304556-1f47gvys 173 37 , , , cord-304556-1f47gvys 173 38 which which WDT cord-304556-1f47gvys 173 39 is be VBZ cord-304556-1f47gvys 173 40 preferentially preferentially RB cord-304556-1f47gvys 173 41 expressed express VBN cord-304556-1f47gvys 173 42 on on IN cord-304556-1f47gvys 173 43 specific specific JJ cord-304556-1f47gvys 173 44 lymphocyte lymphocyte NN cord-304556-1f47gvys 173 45 populations population NNS cord-304556-1f47gvys 173 46 , , , cord-304556-1f47gvys 173 47 is be VBZ cord-304556-1f47gvys 173 48 an an DT cord-304556-1f47gvys 173 49 important important JJ cord-304556-1f47gvys 173 50 susceptibility susceptibility NN cord-304556-1f47gvys 173 51 gene gene NN cord-304556-1f47gvys 173 52 for for IN cord-304556-1f47gvys 173 53 allergic allergic JJ cord-304556-1f47gvys 173 54 asthma asthma NN cord-304556-1f47gvys 173 55 [ [ -LRB- cord-304556-1f47gvys 173 56 102 102 CD cord-304556-1f47gvys 173 57 ] ] -RRB- cord-304556-1f47gvys 173 58 . . . cord-304556-1f47gvys 174 1 Targeting target VBG cord-304556-1f47gvys 174 2 TIM-1 TIM-1 NNP cord-304556-1f47gvys 174 3 modulates modulate VBZ cord-304556-1f47gvys 174 4 airway airway JJ cord-304556-1f47gvys 174 5 inflammation inflammation NN cord-304556-1f47gvys 174 6 in in IN cord-304556-1f47gvys 174 7 mouse mouse NN cord-304556-1f47gvys 174 8 models model NNS cord-304556-1f47gvys 174 9 of of IN cord-304556-1f47gvys 174 10 airway airway NN cord-304556-1f47gvys 174 11 hyper hyper NN cord-304556-1f47gvys 174 12 - - NN cord-304556-1f47gvys 174 13 responsiveness responsiveness NN cord-304556-1f47gvys 174 14 at at IN cord-304556-1f47gvys 174 15 least least JJS cord-304556-1f47gvys 174 16 in in IN cord-304556-1f47gvys 174 17 part part NN cord-304556-1f47gvys 174 18 through through IN cord-304556-1f47gvys 174 19 TIM-1-dependent tim-1-dependent NN cord-304556-1f47gvys 174 20 interaction interaction NN cord-304556-1f47gvys 174 21 of of IN cord-304556-1f47gvys 174 22 NKT NKT NNP cord-304556-1f47gvys 174 23 cells cell NNS cord-304556-1f47gvys 174 24 with with IN cord-304556-1f47gvys 174 25 PtdSer PtdSer NNP cord-304556-1f47gvys 174 26 on on IN cord-304556-1f47gvys 174 27 the the DT cord-304556-1f47gvys 174 28 surface surface NN cord-304556-1f47gvys 174 29 of of IN cord-304556-1f47gvys 174 30 apoptotic apoptotic JJ cord-304556-1f47gvys 174 31 cells cell NNS cord-304556-1f47gvys 174 32 [ [ -LRB- cord-304556-1f47gvys 174 33 103 103 CD cord-304556-1f47gvys 174 34 , , , cord-304556-1f47gvys 174 35 104 104 CD cord-304556-1f47gvys 174 36 ] ] -RRB- cord-304556-1f47gvys 174 37 . . . cord-304556-1f47gvys 175 1 These these DT cord-304556-1f47gvys 175 2 observations observation NNS cord-304556-1f47gvys 175 3 suggest suggest VBP cord-304556-1f47gvys 175 4 that that IN cord-304556-1f47gvys 175 5 recognition recognition NN cord-304556-1f47gvys 175 6 of of IN cord-304556-1f47gvys 175 7 PtdSer PtdSer NNP cord-304556-1f47gvys 175 8 by by IN cord-304556-1f47gvys 175 9 immune immune JJ cord-304556-1f47gvys 175 10 cells cell NNS cord-304556-1f47gvys 175 11 that that WDT cord-304556-1f47gvys 175 12 do do VBP cord-304556-1f47gvys 175 13 not not RB cord-304556-1f47gvys 175 14 phagocytose phagocytose VB cord-304556-1f47gvys 175 15 apoptotic apoptotic JJ cord-304556-1f47gvys 175 16 cells cell NNS cord-304556-1f47gvys 175 17 also also RB cord-304556-1f47gvys 175 18 has have VBZ cord-304556-1f47gvys 175 19 profound profound JJ cord-304556-1f47gvys 175 20 effects effect NNS cord-304556-1f47gvys 175 21 on on IN cord-304556-1f47gvys 175 22 the the DT cord-304556-1f47gvys 175 23 development development NN cord-304556-1f47gvys 175 24 of of IN cord-304556-1f47gvys 175 25 chronic chronic JJ cord-304556-1f47gvys 175 26 lung lung NN cord-304556-1f47gvys 175 27 inflammation inflammation NN cord-304556-1f47gvys 175 28 . . . cord-304556-1f47gvys 176 1 They -PRON- PRP cord-304556-1f47gvys 176 2 also also RB cord-304556-1f47gvys 176 3 indicate indicate VBP cord-304556-1f47gvys 176 4 that that IN cord-304556-1f47gvys 176 5 future future JJ cord-304556-1f47gvys 176 6 studies study NNS cord-304556-1f47gvys 176 7 of of IN cord-304556-1f47gvys 176 8 molecules molecule NNS cord-304556-1f47gvys 176 9 involved involve VBN cord-304556-1f47gvys 176 10 in in IN cord-304556-1f47gvys 176 11 apoptotic apoptotic JJ cord-304556-1f47gvys 176 12 cell cell NN cord-304556-1f47gvys 176 13 binding bind VBG cord-304556-1f47gvys 176 14 in in IN cord-304556-1f47gvys 176 15 asthma asthma NN cord-304556-1f47gvys 176 16 should should MD cord-304556-1f47gvys 176 17 not not RB cord-304556-1f47gvys 176 18 be be VB cord-304556-1f47gvys 176 19 restricted restrict VBN cord-304556-1f47gvys 176 20 to to IN cord-304556-1f47gvys 176 21 analyses analysis NNS cord-304556-1f47gvys 176 22 of of IN cord-304556-1f47gvys 176 23 airway airway NN cord-304556-1f47gvys 176 24 macrophages macrophage NNS cord-304556-1f47gvys 176 25 as as IN cord-304556-1f47gvys 176 26 the the DT cord-304556-1f47gvys 176 27 main main JJ cord-304556-1f47gvys 176 28 contributors contributor NNS cord-304556-1f47gvys 176 29 to to IN cord-304556-1f47gvys 176 30 apoptotic apoptotic JJ cord-304556-1f47gvys 176 31 cell cell NN cord-304556-1f47gvys 176 32 clearance clearance NN cord-304556-1f47gvys 176 33 from from IN cord-304556-1f47gvys 176 34 the the DT cord-304556-1f47gvys 176 35 inflamed inflamed JJ cord-304556-1f47gvys 176 36 airways airway NNS cord-304556-1f47gvys 176 37 . . . cord-304556-1f47gvys 177 1 Interestingly interestingly RB cord-304556-1f47gvys 177 2 , , , cord-304556-1f47gvys 177 3 not not RB cord-304556-1f47gvys 177 4 only only RB cord-304556-1f47gvys 177 5 efferocytosis efferocytosis NN cord-304556-1f47gvys 177 6 but but CC cord-304556-1f47gvys 177 7 also also RB cord-304556-1f47gvys 177 8 engulfment engulfment NN cord-304556-1f47gvys 177 9 of of IN cord-304556-1f47gvys 177 10 bacteria bacteria NNS cord-304556-1f47gvys 177 11 by by IN cord-304556-1f47gvys 177 12 airway airway NN cord-304556-1f47gvys 177 13 macrophages macrophage NNS cord-304556-1f47gvys 177 14 is be VBZ cord-304556-1f47gvys 177 15 impaired impair VBN cord-304556-1f47gvys 177 16 in in IN cord-304556-1f47gvys 177 17 asthma asthma NN cord-304556-1f47gvys 177 18 [ [ -LRB- cord-304556-1f47gvys 177 19 105 105 CD cord-304556-1f47gvys 177 20 ] ] -RRB- cord-304556-1f47gvys 177 21 . . . cord-304556-1f47gvys 178 1 This this DT cord-304556-1f47gvys 178 2 finding finding NN cord-304556-1f47gvys 178 3 indicates indicate VBZ cord-304556-1f47gvys 178 4 that that IN cord-304556-1f47gvys 178 5 alterations alteration NNS cord-304556-1f47gvys 178 6 in in IN cord-304556-1f47gvys 178 7 the the DT cord-304556-1f47gvys 178 8 intracellular intracellular JJ cord-304556-1f47gvys 178 9 molecular molecular JJ cord-304556-1f47gvys 178 10 machinery machinery NN cord-304556-1f47gvys 178 11 regulating regulate VBG cord-304556-1f47gvys 178 12 phagocytosis phagocytosis NN cord-304556-1f47gvys 178 13 rather rather RB cord-304556-1f47gvys 178 14 than than IN cord-304556-1f47gvys 178 15 changes change NNS cord-304556-1f47gvys 178 16 in in IN cord-304556-1f47gvys 178 17 expression expression NN cord-304556-1f47gvys 178 18 of of IN cord-304556-1f47gvys 178 19 receptors receptor NNS cord-304556-1f47gvys 178 20 recognising recognise VBG cord-304556-1f47gvys 178 21 apoptotic apoptotic JJ cord-304556-1f47gvys 178 22 cells cell NNS cord-304556-1f47gvys 178 23 might may MD cord-304556-1f47gvys 178 24 be be VB cord-304556-1f47gvys 178 25 responsible responsible JJ cord-304556-1f47gvys 178 26 for for IN cord-304556-1f47gvys 178 27 the the DT cord-304556-1f47gvys 178 28 observed observed JJ cord-304556-1f47gvys 178 29 phagocytosis phagocytosis NN cord-304556-1f47gvys 178 30 defects defect NNS cord-304556-1f47gvys 178 31 . . . cord-304556-1f47gvys 179 1 Finally finally RB cord-304556-1f47gvys 179 2 , , , cord-304556-1f47gvys 179 3 while while IN cord-304556-1f47gvys 179 4 previous previous JJ cord-304556-1f47gvys 179 5 studies study NNS cord-304556-1f47gvys 179 6 have have VBP cord-304556-1f47gvys 179 7 solely solely RB cord-304556-1f47gvys 179 8 focused focus VBN cord-304556-1f47gvys 179 9 on on IN cord-304556-1f47gvys 179 10 efferocytosis efferocytosis NN cord-304556-1f47gvys 179 11 by by IN cord-304556-1f47gvys 179 12 airway airway NN cord-304556-1f47gvys 179 13 macrophages macrophage NNS cord-304556-1f47gvys 179 14 , , , cord-304556-1f47gvys 179 15 mounting mount VBG cord-304556-1f47gvys 179 16 evidence evidence NN cord-304556-1f47gvys 179 17 suggests suggest VBZ cord-304556-1f47gvys 179 18 that that IN cord-304556-1f47gvys 179 19 bronchial bronchial JJ cord-304556-1f47gvys 179 20 epithelial epithelial JJ cord-304556-1f47gvys 179 21 cells cell NNS cord-304556-1f47gvys 179 22 might may MD cord-304556-1f47gvys 179 23 be be VB cord-304556-1f47gvys 179 24 equally equally RB cord-304556-1f47gvys 179 25 important important JJ cord-304556-1f47gvys 179 26 in in IN cord-304556-1f47gvys 179 27 clearing clear VBG cord-304556-1f47gvys 179 28 apoptotic apoptotic JJ cord-304556-1f47gvys 179 29 cells cell NNS cord-304556-1f47gvys 179 30 from from IN cord-304556-1f47gvys 179 31 the the DT cord-304556-1f47gvys 179 32 inflamed inflamed JJ cord-304556-1f47gvys 179 33 airways airway NNS cord-304556-1f47gvys 179 34 . . . cord-304556-1f47gvys 180 1 Even even RB cord-304556-1f47gvys 180 2 though though IN cord-304556-1f47gvys 180 3 epithelial epithelial JJ cord-304556-1f47gvys 180 4 cells cell NNS cord-304556-1f47gvys 180 5 are be VBP cord-304556-1f47gvys 180 6 not not RB cord-304556-1f47gvys 180 7 professional professional JJ cord-304556-1f47gvys 180 8 phagocytes phagocyte NNS cord-304556-1f47gvys 180 9 , , , cord-304556-1f47gvys 180 10 they -PRON- PRP cord-304556-1f47gvys 180 11 efficiently efficiently RB cord-304556-1f47gvys 180 12 engulf engulf VBP cord-304556-1f47gvys 180 13 apoptotic apoptotic JJ cord-304556-1f47gvys 180 14 eosinophils eosinophil NNS cord-304556-1f47gvys 180 15 , , , cord-304556-1f47gvys 180 16 but but CC cord-304556-1f47gvys 180 17 not not RB cord-304556-1f47gvys 180 18 neutrophils neutrophil NNS cord-304556-1f47gvys 180 19 [ [ -LRB- cord-304556-1f47gvys 180 20 94 94 CD cord-304556-1f47gvys 180 21 , , , cord-304556-1f47gvys 180 22 106 106 CD cord-304556-1f47gvys 180 23 ] ] -RRB- cord-304556-1f47gvys 180 24 . . . cord-304556-1f47gvys 181 1 Animal animal NN cord-304556-1f47gvys 181 2 studies study NNS cord-304556-1f47gvys 181 3 demonstrate demonstrate VBP cord-304556-1f47gvys 181 4 a a DT cord-304556-1f47gvys 181 5 critical critical JJ cord-304556-1f47gvys 181 6 role role NN cord-304556-1f47gvys 181 7 for for IN cord-304556-1f47gvys 181 8 airway airway NN cord-304556-1f47gvys 181 9 epithelial epithelial JJ cord-304556-1f47gvys 181 10 cells cell NNS cord-304556-1f47gvys 181 11 in in IN cord-304556-1f47gvys 181 12 the the DT cord-304556-1f47gvys 181 13 removal removal NN cord-304556-1f47gvys 181 14 of of IN cord-304556-1f47gvys 181 15 apoptotic apoptotic JJ cord-304556-1f47gvys 181 16 cells cell NNS cord-304556-1f47gvys 181 17 from from IN cord-304556-1f47gvys 181 18 the the DT cord-304556-1f47gvys 181 19 inflamed inflamed JJ cord-304556-1f47gvys 181 20 lung lung NN cord-304556-1f47gvys 181 21 and and CC cord-304556-1f47gvys 181 22 , , , cord-304556-1f47gvys 181 23 as as IN cord-304556-1f47gvys 181 24 a a DT cord-304556-1f47gvys 181 25 consequence consequence NN cord-304556-1f47gvys 181 26 , , , cord-304556-1f47gvys 181 27 control control NN cord-304556-1f47gvys 181 28 of of IN cord-304556-1f47gvys 181 29 inflammatory inflammatory JJ cord-304556-1f47gvys 181 30 responses response NNS cord-304556-1f47gvys 181 31 in in IN cord-304556-1f47gvys 181 32 the the DT cord-304556-1f47gvys 181 33 murine murine JJ cord-304556-1f47gvys 181 34 model model NN cord-304556-1f47gvys 181 35 of of IN cord-304556-1f47gvys 181 36 allergic allergic JJ cord-304556-1f47gvys 181 37 airway airway NNP cord-304556-1f47gvys 181 38 hyper hyper NN cord-304556-1f47gvys 181 39 - - NN cord-304556-1f47gvys 181 40 responsiveness responsiveness NN cord-304556-1f47gvys 181 41 [ [ -LRB- cord-304556-1f47gvys 181 42 68 68 CD cord-304556-1f47gvys 181 43 ] ] -RRB- cord-304556-1f47gvys 181 44 . . . cord-304556-1f47gvys 182 1 Future future JJ cord-304556-1f47gvys 182 2 studies study NNS cord-304556-1f47gvys 182 3 in in IN cord-304556-1f47gvys 182 4 humans human NNS cord-304556-1f47gvys 182 5 are be VBP cord-304556-1f47gvys 182 6 therefore therefore RB cord-304556-1f47gvys 182 7 necessary necessary JJ cord-304556-1f47gvys 182 8 to to TO cord-304556-1f47gvys 182 9 characterise characterise VB cord-304556-1f47gvys 182 10 the the DT cord-304556-1f47gvys 182 11 relative relative JJ cord-304556-1f47gvys 182 12 contributions contribution NNS cord-304556-1f47gvys 182 13 of of IN cord-304556-1f47gvys 182 14 airway airway NN cord-304556-1f47gvys 182 15 macrophages macrophage NNS cord-304556-1f47gvys 182 16 and and CC cord-304556-1f47gvys 182 17 bronchial bronchial JJ cord-304556-1f47gvys 182 18 epithelial epithelial JJ cord-304556-1f47gvys 182 19 cells cell NNS cord-304556-1f47gvys 182 20 to to IN cord-304556-1f47gvys 182 21 defects defect NNS cord-304556-1f47gvys 182 22 in in IN cord-304556-1f47gvys 182 23 apoptotic apoptotic JJ cord-304556-1f47gvys 182 24 cell cell NN cord-304556-1f47gvys 182 25 removal removal NN cord-304556-1f47gvys 182 26 in in IN cord-304556-1f47gvys 182 27 asthma asthma NN cord-304556-1f47gvys 182 28 and and CC cord-304556-1f47gvys 182 29 to to TO cord-304556-1f47gvys 182 30 identify identify VB cord-304556-1f47gvys 182 31 therapeutic therapeutic JJ cord-304556-1f47gvys 182 32 strategies strategy NNS cord-304556-1f47gvys 182 33 which which WDT cord-304556-1f47gvys 182 34 could could MD cord-304556-1f47gvys 182 35 restore restore VB cord-304556-1f47gvys 182 36 and/or and/or CC cord-304556-1f47gvys 182 37 promote promote VB cord-304556-1f47gvys 182 38 the the DT cord-304556-1f47gvys 182 39 efferocytic efferocytic JJ cord-304556-1f47gvys 182 40 function function NN cord-304556-1f47gvys 182 41 of of IN cord-304556-1f47gvys 182 42 both both DT cord-304556-1f47gvys 182 43 cell cell NN cord-304556-1f47gvys 182 44 types type NNS cord-304556-1f47gvys 182 45 , , , cord-304556-1f47gvys 182 46 as as RB cord-304556-1f47gvys 182 47 well well RB cord-304556-1f47gvys 182 48 as as IN cord-304556-1f47gvys 182 49 activate activate VB cord-304556-1f47gvys 182 50 anti anti JJ cord-304556-1f47gvys 182 51 - - JJ cord-304556-1f47gvys 182 52 inflammatory inflammatory JJ cord-304556-1f47gvys 182 53 transcriptional transcriptional JJ cord-304556-1f47gvys 182 54 programmes programme NNS cord-304556-1f47gvys 182 55 associated associate VBN cord-304556-1f47gvys 182 56 with with IN cord-304556-1f47gvys 182 57 apoptotic apoptotic JJ cord-304556-1f47gvys 182 58 cell cell NN cord-304556-1f47gvys 182 59 recognition recognition NN cord-304556-1f47gvys 182 60 . . . cord-304556-1f47gvys 183 1 Cystic cystic JJ cord-304556-1f47gvys 183 2 fibrosis fibrosis NN cord-304556-1f47gvys 183 3 ( ( -LRB- cord-304556-1f47gvys 183 4 CF CF NNP cord-304556-1f47gvys 183 5 ) ) -RRB- cord-304556-1f47gvys 183 6 is be VBZ cord-304556-1f47gvys 183 7 a a DT cord-304556-1f47gvys 183 8 heritable heritable JJ cord-304556-1f47gvys 183 9 disorder disorder NN cord-304556-1f47gvys 183 10 caused cause VBN cord-304556-1f47gvys 183 11 by by IN cord-304556-1f47gvys 183 12 mutation mutation NN cord-304556-1f47gvys 183 13 in in IN cord-304556-1f47gvys 183 14 the the DT cord-304556-1f47gvys 183 15 CF cf NN cord-304556-1f47gvys 183 16 transmembrane transmembrane NN cord-304556-1f47gvys 183 17 conductance conductance NN cord-304556-1f47gvys 183 18 regulator regulator NN cord-304556-1f47gvys 183 19 ( ( -LRB- cord-304556-1f47gvys 183 20 CFTR CFTR NNP cord-304556-1f47gvys 183 21 ) ) -RRB- cord-304556-1f47gvys 183 22 and and CC cord-304556-1f47gvys 183 23 characterised characterise VBN cord-304556-1f47gvys 183 24 by by IN cord-304556-1f47gvys 183 25 severe severe JJ cord-304556-1f47gvys 183 26 pulmonary pulmonary JJ cord-304556-1f47gvys 183 27 manifestations manifestation NNS cord-304556-1f47gvys 183 28 . . . cord-304556-1f47gvys 184 1 Impaired impaired JJ cord-304556-1f47gvys 184 2 mucociliary mucociliary JJ cord-304556-1f47gvys 184 3 clearance clearance NN cord-304556-1f47gvys 184 4 in in IN cord-304556-1f47gvys 184 5 CF CF NNP cord-304556-1f47gvys 184 6 patients patient NNS cord-304556-1f47gvys 184 7 prevents prevent VBZ cord-304556-1f47gvys 184 8 elimination elimination NN cord-304556-1f47gvys 184 9 of of IN cord-304556-1f47gvys 184 10 bacteria bacteria NNS cord-304556-1f47gvys 184 11 from from IN cord-304556-1f47gvys 184 12 the the DT cord-304556-1f47gvys 184 13 lung lung NN cord-304556-1f47gvys 184 14 , , , cord-304556-1f47gvys 184 15 leading lead VBG cord-304556-1f47gvys 184 16 to to IN cord-304556-1f47gvys 184 17 persistent persistent JJ cord-304556-1f47gvys 184 18 neutrophilic neutrophilic JJ cord-304556-1f47gvys 184 19 inflammation inflammation NN cord-304556-1f47gvys 184 20 and and CC cord-304556-1f47gvys 184 21 progressive progressive JJ cord-304556-1f47gvys 184 22 , , , cord-304556-1f47gvys 184 23 irreversible irreversible JJ cord-304556-1f47gvys 184 24 damage damage NN cord-304556-1f47gvys 184 25 of of IN cord-304556-1f47gvys 184 26 the the DT cord-304556-1f47gvys 184 27 airways airways NNPS cord-304556-1f47gvys 184 28 [ [ -LRB- cord-304556-1f47gvys 184 29 107 107 CD cord-304556-1f47gvys 184 30 ] ] -RRB- cord-304556-1f47gvys 184 31 . . . cord-304556-1f47gvys 185 1 Similar similar JJ cord-304556-1f47gvys 185 2 to to IN cord-304556-1f47gvys 185 3 other other JJ cord-304556-1f47gvys 185 4 lung lung NN cord-304556-1f47gvys 185 5 diseases disease NNS cord-304556-1f47gvys 185 6 associated associate VBN cord-304556-1f47gvys 185 7 with with IN cord-304556-1f47gvys 185 8 chronic chronic JJ cord-304556-1f47gvys 185 9 inflammation inflammation NN cord-304556-1f47gvys 185 10 , , , cord-304556-1f47gvys 185 11 both both DT cord-304556-1f47gvys 185 12 accumulation accumulation NN cord-304556-1f47gvys 185 13 of of IN cord-304556-1f47gvys 185 14 apoptotic apoptotic JJ cord-304556-1f47gvys 185 15 cells cell NNS cord-304556-1f47gvys 185 16 in in IN cord-304556-1f47gvys 185 17 the the DT cord-304556-1f47gvys 185 18 airways airway NNS cord-304556-1f47gvys 185 19 and and CC cord-304556-1f47gvys 185 20 reduced reduce VBN cord-304556-1f47gvys 185 21 numbers number NNS cord-304556-1f47gvys 185 22 of of IN cord-304556-1f47gvys 185 23 phagocytic phagocytic JJ cord-304556-1f47gvys 185 24 bodies body NNS cord-304556-1f47gvys 185 25 within within IN cord-304556-1f47gvys 185 26 sputum sputum NN cord-304556-1f47gvys 185 27 macrophages macrophage NNS cord-304556-1f47gvys 185 28 are be VBP cord-304556-1f47gvys 185 29 observed observe VBN cord-304556-1f47gvys 185 30 in in IN cord-304556-1f47gvys 185 31 patients patient NNS cord-304556-1f47gvys 185 32 with with IN cord-304556-1f47gvys 185 33 CF cf NN cord-304556-1f47gvys 185 34 compared compare VBN cord-304556-1f47gvys 185 35 to to TO cord-304556-1f47gvys 185 36 control control VB cord-304556-1f47gvys 185 37 patients patient NNS cord-304556-1f47gvys 185 38 with with IN cord-304556-1f47gvys 185 39 chronic chronic JJ cord-304556-1f47gvys 185 40 bronchitis bronchitis NN cord-304556-1f47gvys 185 41 [ [ -LRB- cord-304556-1f47gvys 185 42 25 25 CD cord-304556-1f47gvys 185 43 ] ] -RRB- cord-304556-1f47gvys 185 44 . . . cord-304556-1f47gvys 186 1 Mechanistically Mechanistically NNP cord-304556-1f47gvys 186 2 , , , cord-304556-1f47gvys 186 3 degranulation degranulation NN cord-304556-1f47gvys 186 4 products product NNS cord-304556-1f47gvys 186 5 of of IN cord-304556-1f47gvys 186 6 immune immune JJ cord-304556-1f47gvys 186 7 cells cell NNS cord-304556-1f47gvys 186 8 are be VBP cord-304556-1f47gvys 186 9 partly partly RB cord-304556-1f47gvys 186 10 responsible responsible JJ cord-304556-1f47gvys 186 11 for for IN cord-304556-1f47gvys 186 12 efferocytosis efferocytosis NN cord-304556-1f47gvys 186 13 defects defect NNS cord-304556-1f47gvys 186 14 in in IN cord-304556-1f47gvys 186 15 CF CF NNP cord-304556-1f47gvys 186 16 as as IN cord-304556-1f47gvys 186 17 neutrophil neutrophil NN cord-304556-1f47gvys 186 18 elastase elastase NN cord-304556-1f47gvys 186 19 present present JJ cord-304556-1f47gvys 186 20 in in IN cord-304556-1f47gvys 186 21 the the DT cord-304556-1f47gvys 186 22 airway airway NN cord-304556-1f47gvys 186 23 fluid fluid NN cord-304556-1f47gvys 186 24 of of IN cord-304556-1f47gvys 186 25 CF cf NN cord-304556-1f47gvys 186 26 patients patient NNS cord-304556-1f47gvys 186 27 selectively selectively RB cord-304556-1f47gvys 186 28 cleaves cleave VBZ cord-304556-1f47gvys 186 29 PtdSer PtdSer NNP cord-304556-1f47gvys 186 30 recognition recognition NN cord-304556-1f47gvys 186 31 receptors receptor NNS cord-304556-1f47gvys 186 32 and and CC cord-304556-1f47gvys 186 33 suppresses suppress VBZ cord-304556-1f47gvys 186 34 apoptotic apoptotic JJ cord-304556-1f47gvys 186 35 cell cell NN cord-304556-1f47gvys 186 36 removal removal NN cord-304556-1f47gvys 186 37 by by IN cord-304556-1f47gvys 186 38 airway airway NN cord-304556-1f47gvys 186 39 macrophages macrophage NNS cord-304556-1f47gvys 186 40 [ [ -LRB- cord-304556-1f47gvys 186 41 25 25 CD cord-304556-1f47gvys 186 42 ] ] -RRB- cord-304556-1f47gvys 186 43 . . . cord-304556-1f47gvys 187 1 Other other JJ cord-304556-1f47gvys 187 2 potential potential JJ cord-304556-1f47gvys 187 3 mechanisms mechanism NNS cord-304556-1f47gvys 187 4 contributing contribute VBG cord-304556-1f47gvys 187 5 to to IN cord-304556-1f47gvys 187 6 impaired impaired JJ cord-304556-1f47gvys 187 7 apoptotic apoptotic JJ cord-304556-1f47gvys 187 8 cell cell NN cord-304556-1f47gvys 187 9 clearance clearance NN cord-304556-1f47gvys 187 10 in in IN cord-304556-1f47gvys 187 11 CF CF NNP cord-304556-1f47gvys 187 12 involve involve VBP cord-304556-1f47gvys 187 13 the the DT cord-304556-1f47gvys 187 14 release release NN cord-304556-1f47gvys 187 15 of of IN cord-304556-1f47gvys 187 16 HMGB1 HMGB1 NNP cord-304556-1f47gvys 187 17 which which WDT cord-304556-1f47gvys 187 18 , , , cord-304556-1f47gvys 187 19 similar similar JJ cord-304556-1f47gvys 187 20 to to IN cord-304556-1f47gvys 187 21 COPD COPD NNP cord-304556-1f47gvys 187 22 , , , cord-304556-1f47gvys 187 23 is be VBZ cord-304556-1f47gvys 187 24 elevated elevate VBN cord-304556-1f47gvys 187 25 in in IN cord-304556-1f47gvys 187 26 sputum sputum NN cord-304556-1f47gvys 187 27 samples sample NNS cord-304556-1f47gvys 187 28 from from IN cord-304556-1f47gvys 187 29 CF CF NNP cord-304556-1f47gvys 187 30 patients patient NNS cord-304556-1f47gvys 187 31 [ [ -LRB- cord-304556-1f47gvys 187 32 108 108 CD cord-304556-1f47gvys 187 33 ] ] -RRB- cord-304556-1f47gvys 187 34 and and CC cord-304556-1f47gvys 187 35 effects effect NNS cord-304556-1f47gvys 187 36 of of IN cord-304556-1f47gvys 187 37 bacterial bacterial JJ cord-304556-1f47gvys 187 38 products product NNS cord-304556-1f47gvys 187 39 on on IN cord-304556-1f47gvys 187 40 airway airway NN cord-304556-1f47gvys 187 41 macrophages macrophage NNS cord-304556-1f47gvys 187 42 . . . cord-304556-1f47gvys 188 1 Pseudomonas Pseudomonas NNP cord-304556-1f47gvys 188 2 aeruginosa aeruginosa NN cord-304556-1f47gvys 188 3 infections infection NNS cord-304556-1f47gvys 188 4 are be VBP cord-304556-1f47gvys 188 5 common common JJ cord-304556-1f47gvys 188 6 in in IN cord-304556-1f47gvys 188 7 CF CF NNP cord-304556-1f47gvys 188 8 and and CC cord-304556-1f47gvys 188 9 represent represent VB cord-304556-1f47gvys 188 10 an an DT cord-304556-1f47gvys 188 11 important important JJ cord-304556-1f47gvys 188 12 cause cause NN cord-304556-1f47gvys 188 13 of of IN cord-304556-1f47gvys 188 14 mortality mortality NN cord-304556-1f47gvys 188 15 in in IN cord-304556-1f47gvys 188 16 CF cf NN cord-304556-1f47gvys 188 17 lung lung NN cord-304556-1f47gvys 188 18 manifestations manifestation NNS cord-304556-1f47gvys 188 19 . . . cord-304556-1f47gvys 189 1 In in IN cord-304556-1f47gvys 189 2 vitro vitro FW cord-304556-1f47gvys 189 3 , , , cord-304556-1f47gvys 189 4 P. p. NN cord-304556-1f47gvys 189 5 aeruginosa aeruginosa NN cord-304556-1f47gvys 189 6 toxic toxic JJ cord-304556-1f47gvys 189 7 metabolite metabolite NN cord-304556-1f47gvys 189 8 pyocyanin pyocyanin NN cord-304556-1f47gvys 189 9 and and CC cord-304556-1f47gvys 189 10 the the DT cord-304556-1f47gvys 189 11 polysaccharide polysaccharide NN cord-304556-1f47gvys 189 12 alginate alginate NN cord-304556-1f47gvys 189 13 inhibit inhibit VBP cord-304556-1f47gvys 189 14 apoptotic apoptotic JJ cord-304556-1f47gvys 189 15 cell cell NN cord-304556-1f47gvys 189 16 uptake uptake NN cord-304556-1f47gvys 189 17 by by IN cord-304556-1f47gvys 189 18 macrophages macrophage NNS cord-304556-1f47gvys 189 19 [ [ -LRB- cord-304556-1f47gvys 189 20 109 109 CD cord-304556-1f47gvys 189 21 , , , cord-304556-1f47gvys 189 22 110 110 CD cord-304556-1f47gvys 189 23 ] ] -RRB- cord-304556-1f47gvys 189 24 , , , cord-304556-1f47gvys 189 25 though though IN cord-304556-1f47gvys 189 26 the the DT cord-304556-1f47gvys 189 27 relevance relevance NN cord-304556-1f47gvys 189 28 of of IN cord-304556-1f47gvys 189 29 this this DT cord-304556-1f47gvys 189 30 mechanism mechanism NN cord-304556-1f47gvys 189 31 in in IN cord-304556-1f47gvys 189 32 patients patient NNS cord-304556-1f47gvys 189 33 has have VBZ cord-304556-1f47gvys 189 34 yet yet RB cord-304556-1f47gvys 189 35 to to TO cord-304556-1f47gvys 189 36 be be VB cord-304556-1f47gvys 189 37 demonstrated demonstrate VBN cord-304556-1f47gvys 189 38 . . . cord-304556-1f47gvys 190 1 Interestingly interestingly RB cord-304556-1f47gvys 190 2 , , , cord-304556-1f47gvys 190 3 animal animal NN cord-304556-1f47gvys 190 4 studies study NNS cord-304556-1f47gvys 190 5 indicate indicate VBP cord-304556-1f47gvys 190 6 that that IN cord-304556-1f47gvys 190 7 airway airway JJ cord-304556-1f47gvys 190 8 epithelial epithelial JJ cord-304556-1f47gvys 190 9 cells cell NNS cord-304556-1f47gvys 190 10 in in IN cord-304556-1f47gvys 190 11 CF CF NNP cord-304556-1f47gvys 190 12 might may MD cord-304556-1f47gvys 190 13 also also RB cord-304556-1f47gvys 190 14 be be VB cord-304556-1f47gvys 190 15 deficient deficient JJ cord-304556-1f47gvys 190 16 in in IN cord-304556-1f47gvys 190 17 phagocytic phagocytic JJ cord-304556-1f47gvys 190 18 functions function NNS cord-304556-1f47gvys 190 19 . . . cord-304556-1f47gvys 191 1 While while IN cord-304556-1f47gvys 191 2 defective defective JJ cord-304556-1f47gvys 191 3 efferocytosis efferocytosis NN cord-304556-1f47gvys 191 4 by by IN cord-304556-1f47gvys 191 5 airway airway NN cord-304556-1f47gvys 191 6 macrophages macrophage NNS cord-304556-1f47gvys 191 7 in in IN cord-304556-1f47gvys 191 8 CF CF NNP cord-304556-1f47gvys 191 9 patients patient NNS cord-304556-1f47gvys 191 10 is be VBZ cord-304556-1f47gvys 191 11 a a DT cord-304556-1f47gvys 191 12 consequence consequence NN cord-304556-1f47gvys 191 13 of of IN cord-304556-1f47gvys 191 14 the the DT cord-304556-1f47gvys 191 15 ongoing ongoing JJ cord-304556-1f47gvys 191 16 inflammatory inflammatory JJ cord-304556-1f47gvys 191 17 response response NN cord-304556-1f47gvys 191 18 and/or and/or CC cord-304556-1f47gvys 191 19 microbial microbial JJ cord-304556-1f47gvys 191 20 infection infection NN cord-304556-1f47gvys 191 21 , , , cord-304556-1f47gvys 191 22 impaired impaired JJ cord-304556-1f47gvys 191 23 apoptotic apoptotic JJ cord-304556-1f47gvys 191 24 cell cell NN cord-304556-1f47gvys 191 25 uptake uptake NN cord-304556-1f47gvys 191 26 by by IN cord-304556-1f47gvys 191 27 epithelial epithelial JJ cord-304556-1f47gvys 191 28 cells cell NNS cord-304556-1f47gvys 191 29 might may MD cord-304556-1f47gvys 191 30 be be VB cord-304556-1f47gvys 191 31 directly directly RB cord-304556-1f47gvys 191 32 related relate VBN cord-304556-1f47gvys 191 33 to to IN cord-304556-1f47gvys 191 34 the the DT cord-304556-1f47gvys 191 35 lack lack NN cord-304556-1f47gvys 191 36 of of IN cord-304556-1f47gvys 191 37 CFTR CFTR NNP cord-304556-1f47gvys 191 38 expression expression NN cord-304556-1f47gvys 191 39 . . . cord-304556-1f47gvys 192 1 CFTR CFTR NNP cord-304556-1f47gvys 192 2 - - HYPH cord-304556-1f47gvys 192 3 deficient deficient JJ cord-304556-1f47gvys 192 4 epithelial epithelial JJ cord-304556-1f47gvys 192 5 cells cell NNS cord-304556-1f47gvys 192 6 express express VBP cord-304556-1f47gvys 192 7 significantly significantly RB cord-304556-1f47gvys 192 8 increased increase VBN cord-304556-1f47gvys 192 9 levels level NNS cord-304556-1f47gvys 192 10 of of IN cord-304556-1f47gvys 192 11 RhoA RhoA NNP cord-304556-1f47gvys 192 12 , , , cord-304556-1f47gvys 192 13 which which WDT cord-304556-1f47gvys 192 14 is be VBZ cord-304556-1f47gvys 192 15 a a DT cord-304556-1f47gvys 192 16 negative negative JJ cord-304556-1f47gvys 192 17 regulator regulator NN cord-304556-1f47gvys 192 18 of of IN cord-304556-1f47gvys 192 19 efferoctyosis efferoctyosis NN cord-304556-1f47gvys 192 20 , , , cord-304556-1f47gvys 192 21 and and CC cord-304556-1f47gvys 192 22 RhoA RhoA NNP cord-304556-1f47gvys 192 23 inhibition inhibition NN cord-304556-1f47gvys 192 24 restores restore VBZ cord-304556-1f47gvys 192 25 their -PRON- PRP$ cord-304556-1f47gvys 192 26 phagocytic phagocytic JJ cord-304556-1f47gvys 192 27 function function NN cord-304556-1f47gvys 192 28 [ [ -LRB- cord-304556-1f47gvys 192 29 111 111 CD cord-304556-1f47gvys 192 30 ] ] -RRB- cord-304556-1f47gvys 192 31 . . . cord-304556-1f47gvys 193 1 It -PRON- PRP cord-304556-1f47gvys 193 2 remains remain VBZ cord-304556-1f47gvys 193 3 to to TO cord-304556-1f47gvys 193 4 be be VB cord-304556-1f47gvys 193 5 determined determine VBN cord-304556-1f47gvys 193 6 if if IN cord-304556-1f47gvys 193 7 a a DT cord-304556-1f47gvys 193 8 similar similar JJ cord-304556-1f47gvys 193 9 mechanism mechanism NN cord-304556-1f47gvys 193 10 regulates regulate VBZ cord-304556-1f47gvys 193 11 bronchial bronchial JJ cord-304556-1f47gvys 193 12 epithelial epithelial JJ cord-304556-1f47gvys 193 13 cell cell NN cord-304556-1f47gvys 193 14 efferocytosis efferocytosis NN cord-304556-1f47gvys 193 15 in in IN cord-304556-1f47gvys 193 16 patients patient NNS cord-304556-1f47gvys 193 17 with with IN cord-304556-1f47gvys 193 18 CF CF NNP cord-304556-1f47gvys 193 19 . . . cord-304556-1f47gvys 194 1 Elevated elevated JJ cord-304556-1f47gvys 194 2 levels level NNS cord-304556-1f47gvys 194 3 of of IN cord-304556-1f47gvys 194 4 apoptotic apoptotic JJ cord-304556-1f47gvys 194 5 cells cell NNS cord-304556-1f47gvys 194 6 and and CC cord-304556-1f47gvys 194 7 reduced reduce VBN cord-304556-1f47gvys 194 8 frequencies frequency NNS cord-304556-1f47gvys 194 9 of of IN cord-304556-1f47gvys 194 10 phagocytic phagocytic JJ cord-304556-1f47gvys 194 11 bodies body NNS cord-304556-1f47gvys 194 12 within within IN cord-304556-1f47gvys 194 13 bronchoalveolar bronchoalveolar NNP cord-304556-1f47gvys 194 14 lavage lavage NN cord-304556-1f47gvys 194 15 macrophages macrophage NNS cord-304556-1f47gvys 194 16 have have VBP cord-304556-1f47gvys 194 17 also also RB cord-304556-1f47gvys 194 18 been be VBN cord-304556-1f47gvys 194 19 reported report VBN cord-304556-1f47gvys 194 20 in in IN cord-304556-1f47gvys 194 21 patients patient NNS cord-304556-1f47gvys 194 22 with with IN cord-304556-1f47gvys 194 23 idiopathic idiopathic JJ cord-304556-1f47gvys 194 24 pulmonary pulmonary JJ cord-304556-1f47gvys 194 25 fibrosis fibrosis NN cord-304556-1f47gvys 194 26 ( ( -LRB- cord-304556-1f47gvys 194 27 IPF IPF NNP cord-304556-1f47gvys 194 28 ) ) -RRB- cord-304556-1f47gvys 194 29 [ [ -LRB- cord-304556-1f47gvys 194 30 112 112 CD cord-304556-1f47gvys 194 31 ] ] -RRB- cord-304556-1f47gvys 194 32 . . . cord-304556-1f47gvys 195 1 IPF IPF NNP cord-304556-1f47gvys 195 2 is be VBZ cord-304556-1f47gvys 195 3 an an DT cord-304556-1f47gvys 195 4 interstitial interstitial JJ cord-304556-1f47gvys 195 5 lung lung NN cord-304556-1f47gvys 195 6 disease disease NN cord-304556-1f47gvys 195 7 characterised characterise VBN cord-304556-1f47gvys 195 8 by by IN cord-304556-1f47gvys 195 9 epithelial epithelial JJ cord-304556-1f47gvys 195 10 injury injury NN cord-304556-1f47gvys 195 11 that that WDT cord-304556-1f47gvys 195 12 is be VBZ cord-304556-1f47gvys 195 13 followed follow VBN cord-304556-1f47gvys 195 14 by by IN cord-304556-1f47gvys 195 15 aberrant aberrant JJ cord-304556-1f47gvys 195 16 alveolar alveolar NN cord-304556-1f47gvys 195 17 wound wound NN cord-304556-1f47gvys 195 18 repair repair NN cord-304556-1f47gvys 195 19 and and CC cord-304556-1f47gvys 195 20 scar scar NN cord-304556-1f47gvys 195 21 formation formation NN cord-304556-1f47gvys 195 22 , , , cord-304556-1f47gvys 195 23 which which WDT cord-304556-1f47gvys 195 24 ultimately ultimately RB cord-304556-1f47gvys 195 25 lead lead VBP cord-304556-1f47gvys 195 26 to to IN cord-304556-1f47gvys 195 27 respiratory respiratory JJ cord-304556-1f47gvys 195 28 failure failure NN cord-304556-1f47gvys 195 29 and and CC cord-304556-1f47gvys 195 30 death death NN cord-304556-1f47gvys 195 31 . . . cord-304556-1f47gvys 196 1 IPF IPF NNP cord-304556-1f47gvys 196 2 is be VBZ cord-304556-1f47gvys 196 3 frequently frequently RB cord-304556-1f47gvys 196 4 accompanied accompany VBN cord-304556-1f47gvys 196 5 by by IN cord-304556-1f47gvys 196 6 chronic chronic JJ cord-304556-1f47gvys 196 7 neutrophilic neutrophilic JJ cord-304556-1f47gvys 196 8 inflammation inflammation NN cord-304556-1f47gvys 196 9 [ [ -LRB- cord-304556-1f47gvys 196 10 113 113 CD cord-304556-1f47gvys 196 11 ] ] -RRB- cord-304556-1f47gvys 196 12 . . . cord-304556-1f47gvys 197 1 Interestingly interestingly RB cord-304556-1f47gvys 197 2 , , , cord-304556-1f47gvys 197 3 intratracheal intratracheal JJ cord-304556-1f47gvys 197 4 instillation instillation NN cord-304556-1f47gvys 197 5 of of IN cord-304556-1f47gvys 197 6 apoptotic apoptotic JJ cord-304556-1f47gvys 197 7 cells cell NNS cord-304556-1f47gvys 197 8 ameliorates ameliorate VBZ cord-304556-1f47gvys 197 9 fibrosis fibrosis NN cord-304556-1f47gvys 197 10 and and CC cord-304556-1f47gvys 197 11 inflammation inflammation NN cord-304556-1f47gvys 197 12 in in IN cord-304556-1f47gvys 197 13 bleomycin bleomycin NN cord-304556-1f47gvys 197 14 - - HYPH cord-304556-1f47gvys 197 15 induced induce VBN cord-304556-1f47gvys 197 16 lung lung NN cord-304556-1f47gvys 197 17 injury injury NN cord-304556-1f47gvys 197 18 in in IN cord-304556-1f47gvys 197 19 mice mouse NNS cord-304556-1f47gvys 197 20 [ [ -LRB- cord-304556-1f47gvys 197 21 58 58 CD cord-304556-1f47gvys 197 22 , , , cord-304556-1f47gvys 197 23 114 114 CD cord-304556-1f47gvys 197 24 ] ] -RRB- cord-304556-1f47gvys 197 25 , , , cord-304556-1f47gvys 197 26 indicating indicate VBG cord-304556-1f47gvys 197 27 that that IN cord-304556-1f47gvys 197 28 signalling signal VBG cord-304556-1f47gvys 197 29 triggered trigger VBN cord-304556-1f47gvys 197 30 by by IN cord-304556-1f47gvys 197 31 apoptotic apoptotic JJ cord-304556-1f47gvys 197 32 cell cell NN cord-304556-1f47gvys 197 33 recognition recognition NN cord-304556-1f47gvys 197 34 may may MD cord-304556-1f47gvys 197 35 play play VB cord-304556-1f47gvys 197 36 a a DT cord-304556-1f47gvys 197 37 protective protective JJ cord-304556-1f47gvys 197 38 role role NN cord-304556-1f47gvys 197 39 in in IN cord-304556-1f47gvys 197 40 lung lung NN cord-304556-1f47gvys 197 41 diseases disease NNS cord-304556-1f47gvys 197 42 associated associate VBN cord-304556-1f47gvys 197 43 with with IN cord-304556-1f47gvys 197 44 dysregulated dysregulate VBN cord-304556-1f47gvys 197 45 healing healing NN cord-304556-1f47gvys 197 46 processes process NNS cord-304556-1f47gvys 197 47 . . . cord-304556-1f47gvys 198 1 The the DT cord-304556-1f47gvys 198 2 anti anti JJ cord-304556-1f47gvys 198 3 - - JJ cord-304556-1f47gvys 198 4 fibrotic fibrotic JJ cord-304556-1f47gvys 198 5 effects effect NNS cord-304556-1f47gvys 198 6 of of IN cord-304556-1f47gvys 198 7 apoptotic apoptotic JJ cord-304556-1f47gvys 198 8 cells cell NNS cord-304556-1f47gvys 198 9 in in IN cord-304556-1f47gvys 198 10 this this DT cord-304556-1f47gvys 198 11 model model NN cord-304556-1f47gvys 198 12 are be VBP cord-304556-1f47gvys 198 13 dependent dependent JJ cord-304556-1f47gvys 198 14 on on IN cord-304556-1f47gvys 198 15 the the DT cord-304556-1f47gvys 198 16 induction induction NN cord-304556-1f47gvys 198 17 of of IN cord-304556-1f47gvys 198 18 PPARγ pparγ JJ cord-304556-1f47gvys 198 19 expression expression NN cord-304556-1f47gvys 198 20 in in IN cord-304556-1f47gvys 198 21 airway airway NN cord-304556-1f47gvys 198 22 macrophages macrophage NNS cord-304556-1f47gvys 198 23 and and CC cord-304556-1f47gvys 198 24 increased increase VBN cord-304556-1f47gvys 198 25 production production NN cord-304556-1f47gvys 198 26 of of IN cord-304556-1f47gvys 198 27 hepatocyte hepatocyte NN cord-304556-1f47gvys 198 28 growth growth NN cord-304556-1f47gvys 198 29 factor factor NN cord-304556-1f47gvys 198 30 ( ( -LRB- cord-304556-1f47gvys 198 31 HGF HGF NNP cord-304556-1f47gvys 198 32 ) ) -RRB- cord-304556-1f47gvys 198 33 , , , cord-304556-1f47gvys 198 34 which which WDT cord-304556-1f47gvys 198 35 plays play VBZ cord-304556-1f47gvys 198 36 a a DT cord-304556-1f47gvys 198 37 key key JJ cord-304556-1f47gvys 198 38 role role NN cord-304556-1f47gvys 198 39 in in IN cord-304556-1f47gvys 198 40 alveolar alveolar JJ cord-304556-1f47gvys 198 41 epithelial epithelial JJ cord-304556-1f47gvys 198 42 repair repair NN cord-304556-1f47gvys 198 43 upon upon IN cord-304556-1f47gvys 198 44 lung lung NN cord-304556-1f47gvys 198 45 injury injury NN cord-304556-1f47gvys 198 46 [ [ -LRB- cord-304556-1f47gvys 198 47 58 58 CD cord-304556-1f47gvys 198 48 , , , cord-304556-1f47gvys 198 49 114 114 CD cord-304556-1f47gvys 198 50 ] ] -RRB- cord-304556-1f47gvys 198 51 . . . cord-304556-1f47gvys 199 1 These these DT cord-304556-1f47gvys 199 2 observations observation NNS cord-304556-1f47gvys 199 3 suggest suggest VBP cord-304556-1f47gvys 199 4 that that IN cord-304556-1f47gvys 199 5 defects defect NNS cord-304556-1f47gvys 199 6 in in IN cord-304556-1f47gvys 199 7 efferocytosis efferocytosis NN cord-304556-1f47gvys 199 8 in in IN cord-304556-1f47gvys 199 9 IPF IPF NNP cord-304556-1f47gvys 199 10 patients patient NNS cord-304556-1f47gvys 199 11 may may MD cord-304556-1f47gvys 199 12 be be VB cord-304556-1f47gvys 199 13 responsible responsible JJ cord-304556-1f47gvys 199 14 not not RB cord-304556-1f47gvys 199 15 only only RB cord-304556-1f47gvys 199 16 for for IN cord-304556-1f47gvys 199 17 inefficient inefficient JJ cord-304556-1f47gvys 199 18 clearance clearance NN cord-304556-1f47gvys 199 19 of of IN cord-304556-1f47gvys 199 20 apoptotic apoptotic JJ cord-304556-1f47gvys 199 21 cells cell NNS cord-304556-1f47gvys 199 22 but but CC cord-304556-1f47gvys 199 23 also also RB cord-304556-1f47gvys 199 24 for for IN cord-304556-1f47gvys 199 25 diminished diminished JJ cord-304556-1f47gvys 199 26 production production NN cord-304556-1f47gvys 199 27 of of IN cord-304556-1f47gvys 199 28 factors factor NNS cord-304556-1f47gvys 199 29 that that WDT cord-304556-1f47gvys 199 30 support support VBP cord-304556-1f47gvys 199 31 tissue tissue NN cord-304556-1f47gvys 199 32 repair repair NN cord-304556-1f47gvys 199 33 without without IN cord-304556-1f47gvys 199 34 fibrosis fibrosis NN cord-304556-1f47gvys 199 35 . . . cord-304556-1f47gvys 200 1 Collectively collectively RB cord-304556-1f47gvys 200 2 , , , cord-304556-1f47gvys 200 3 the the DT cord-304556-1f47gvys 200 4 data datum NNS cord-304556-1f47gvys 200 5 from from IN cord-304556-1f47gvys 200 6 patients patient NNS cord-304556-1f47gvys 200 7 with with IN cord-304556-1f47gvys 200 8 asthma asthma NN cord-304556-1f47gvys 200 9 , , , cord-304556-1f47gvys 200 10 COPD COPD NNP cord-304556-1f47gvys 200 11 , , , cord-304556-1f47gvys 200 12 CF CF NNP cord-304556-1f47gvys 200 13 and and CC cord-304556-1f47gvys 200 14 pulmonary pulmonary JJ cord-304556-1f47gvys 200 15 fibrosis fibrosis NN cord-304556-1f47gvys 200 16 indicate indicate VBP cord-304556-1f47gvys 200 17 that that IN cord-304556-1f47gvys 200 18 defective defective JJ cord-304556-1f47gvys 200 19 apoptotic apoptotic JJ cord-304556-1f47gvys 200 20 cell cell NN cord-304556-1f47gvys 200 21 clearance clearance NN cord-304556-1f47gvys 200 22 in in IN cord-304556-1f47gvys 200 23 lung lung NN cord-304556-1f47gvys 200 24 diseases disease NNS cord-304556-1f47gvys 200 25 is be VBZ cord-304556-1f47gvys 200 26 not not RB cord-304556-1f47gvys 200 27 specific specific JJ cord-304556-1f47gvys 200 28 for for IN cord-304556-1f47gvys 200 29 individual individual JJ cord-304556-1f47gvys 200 30 diagnoses diagnosis NNS cord-304556-1f47gvys 200 31 but but CC cord-304556-1f47gvys 200 32 rather rather RB cord-304556-1f47gvys 200 33 represents represent VBZ cord-304556-1f47gvys 200 34 a a DT cord-304556-1f47gvys 200 35 general general JJ cord-304556-1f47gvys 200 36 hallmark hallmark NN cord-304556-1f47gvys 200 37 of of IN cord-304556-1f47gvys 200 38 chronic chronic JJ cord-304556-1f47gvys 200 39 inflammation inflammation NN cord-304556-1f47gvys 200 40 . . . cord-304556-1f47gvys 201 1 Although although IN cord-304556-1f47gvys 201 2 several several JJ cord-304556-1f47gvys 201 3 mechanisms mechanism NNS cord-304556-1f47gvys 201 4 contributing contribute VBG cord-304556-1f47gvys 201 5 to to IN cord-304556-1f47gvys 201 6 these these DT cord-304556-1f47gvys 201 7 defects defect NNS cord-304556-1f47gvys 201 8 have have VBP cord-304556-1f47gvys 201 9 been be VBN cord-304556-1f47gvys 201 10 proposed propose VBN cord-304556-1f47gvys 201 11 , , , cord-304556-1f47gvys 201 12 it -PRON- PRP cord-304556-1f47gvys 201 13 remains remain VBZ cord-304556-1f47gvys 201 14 to to TO cord-304556-1f47gvys 201 15 be be VB cord-304556-1f47gvys 201 16 verified verify VBN cord-304556-1f47gvys 201 17 whether whether IN cord-304556-1f47gvys 201 18 impairment impairment NN cord-304556-1f47gvys 201 19 of of IN cord-304556-1f47gvys 201 20 efferocytosis efferocytosis NN cord-304556-1f47gvys 201 21 might may MD cord-304556-1f47gvys 201 22 be be VB cord-304556-1f47gvys 201 23 a a DT cord-304556-1f47gvys 201 24 direct direct JJ cord-304556-1f47gvys 201 25 cause cause NN cord-304556-1f47gvys 201 26 of of IN cord-304556-1f47gvys 201 27 chronic chronic JJ cord-304556-1f47gvys 201 28 inflammation inflammation NN cord-304556-1f47gvys 201 29 , , , cord-304556-1f47gvys 201 30 or or CC cord-304556-1f47gvys 201 31 is be VBZ cord-304556-1f47gvys 201 32 a a DT cord-304556-1f47gvys 201 33 consequence consequence NN cord-304556-1f47gvys 201 34 to to IN cord-304556-1f47gvys 201 35 the the DT cord-304556-1f47gvys 201 36 ongoing ongoing JJ cord-304556-1f47gvys 201 37 inflammatory inflammatory JJ cord-304556-1f47gvys 201 38 processes process NNS cord-304556-1f47gvys 201 39 that that WDT cord-304556-1f47gvys 201 40 contributes contribute VBZ cord-304556-1f47gvys 201 41 to to IN cord-304556-1f47gvys 201 42 chronicity chronicity NN cord-304556-1f47gvys 201 43 and and CC cord-304556-1f47gvys 201 44 prevents prevent VBZ cord-304556-1f47gvys 201 45 resolution resolution NN cord-304556-1f47gvys 201 46 . . . cord-304556-1f47gvys 202 1 The the DT cord-304556-1f47gvys 202 2 latter latter JJ cord-304556-1f47gvys 202 3 model model NN cord-304556-1f47gvys 202 4 is be VBZ cord-304556-1f47gvys 202 5 supported support VBN cord-304556-1f47gvys 202 6 by by IN cord-304556-1f47gvys 202 7 the the DT cord-304556-1f47gvys 202 8 observation observation NN cord-304556-1f47gvys 202 9 that that IN cord-304556-1f47gvys 202 10 mice mouse NNS cord-304556-1f47gvys 202 11 lacking lack VBG cord-304556-1f47gvys 202 12 the the DT cord-304556-1f47gvys 202 13 TAM TAM NNP cord-304556-1f47gvys 202 14 receptor receptor NN cord-304556-1f47gvys 203 1 Axl Axl NNP cord-304556-1f47gvys 203 2 do do VBP cord-304556-1f47gvys 203 3 not not RB cord-304556-1f47gvys 203 4 develop develop VB cord-304556-1f47gvys 203 5 spontaneous spontaneous JJ cord-304556-1f47gvys 203 6 lung lung NN cord-304556-1f47gvys 203 7 inflammation inflammation NN cord-304556-1f47gvys 203 8 despite despite IN cord-304556-1f47gvys 203 9 defects defect NNS cord-304556-1f47gvys 203 10 in in IN cord-304556-1f47gvys 203 11 apoptotic apoptotic JJ cord-304556-1f47gvys 203 12 cell cell NN cord-304556-1f47gvys 203 13 uptake uptake NN cord-304556-1f47gvys 203 14 by by IN cord-304556-1f47gvys 203 15 airway airway NN cord-304556-1f47gvys 203 16 macrophages macrophage NNS cord-304556-1f47gvys 203 17 [ [ -LRB- cord-304556-1f47gvys 203 18 2 2 CD cord-304556-1f47gvys 203 19 ] ] -RRB- cord-304556-1f47gvys 203 20 , , , cord-304556-1f47gvys 203 21 but but CC cord-304556-1f47gvys 203 22 more more RBR cord-304556-1f47gvys 203 23 detailed detailed JJ cord-304556-1f47gvys 203 24 analyses analysis NNS cord-304556-1f47gvys 203 25 of of IN cord-304556-1f47gvys 203 26 regulation regulation NN cord-304556-1f47gvys 203 27 and and CC cord-304556-1f47gvys 203 28 function function NN cord-304556-1f47gvys 203 29 of of IN cord-304556-1f47gvys 203 30 PtdSer ptdser JJ cord-304556-1f47gvys 203 31 recognition recognition NN cord-304556-1f47gvys 203 32 receptors receptor NNS cord-304556-1f47gvys 203 33 in in IN cord-304556-1f47gvys 203 34 the the DT cord-304556-1f47gvys 203 35 human human JJ cord-304556-1f47gvys 203 36 lung lung NN cord-304556-1f47gvys 203 37 are be VBP cord-304556-1f47gvys 203 38 required require VBN cord-304556-1f47gvys 203 39 . . . cord-304556-1f47gvys 204 1 Finally finally RB cord-304556-1f47gvys 204 2 , , , cord-304556-1f47gvys 204 3 because because IN cord-304556-1f47gvys 204 4 recognition recognition NN cord-304556-1f47gvys 204 5 of of IN cord-304556-1f47gvys 204 6 apoptotic apoptotic JJ cord-304556-1f47gvys 204 7 cells cell NNS cord-304556-1f47gvys 204 8 by by IN cord-304556-1f47gvys 204 9 PtdSer PtdSer NNP cord-304556-1f47gvys 204 10 - - HYPH cord-304556-1f47gvys 204 11 recognising recognise VBG cord-304556-1f47gvys 204 12 receptors receptor NNS cord-304556-1f47gvys 204 13 activates activate VBZ cord-304556-1f47gvys 204 14 downstream downstream JJ cord-304556-1f47gvys 204 15 signalling signal VBG cord-304556-1f47gvys 204 16 pathways pathway NNS cord-304556-1f47gvys 204 17 even even RB cord-304556-1f47gvys 204 18 without without IN cord-304556-1f47gvys 204 19 engulfment engulfment NN cord-304556-1f47gvys 204 20 [ [ -LRB- cord-304556-1f47gvys 204 21 46 46 CD cord-304556-1f47gvys 204 22 ] ] -RRB- cord-304556-1f47gvys 204 23 , , , cord-304556-1f47gvys 204 24 future future JJ cord-304556-1f47gvys 204 25 studies study NNS cord-304556-1f47gvys 204 26 are be VBP cord-304556-1f47gvys 204 27 needed need VBN cord-304556-1f47gvys 204 28 to to TO cord-304556-1f47gvys 204 29 verify verify VB cord-304556-1f47gvys 204 30 whether whether IN cord-304556-1f47gvys 204 31 activation activation NN cord-304556-1f47gvys 204 32 of of IN cord-304556-1f47gvys 204 33 transcriptional transcriptional JJ cord-304556-1f47gvys 204 34 programmes programme NNS cord-304556-1f47gvys 204 35 triggered trigger VBN cord-304556-1f47gvys 204 36 by by IN cord-304556-1f47gvys 204 37 recognition recognition NN cord-304556-1f47gvys 204 38 of of IN cord-304556-1f47gvys 204 39 apoptotic apoptotic JJ cord-304556-1f47gvys 204 40 cells cell NNS cord-304556-1f47gvys 204 41 is be VBZ cord-304556-1f47gvys 204 42 also also RB cord-304556-1f47gvys 204 43 altered alter VBN cord-304556-1f47gvys 204 44 in in IN cord-304556-1f47gvys 204 45 chronic chronic JJ cord-304556-1f47gvys 204 46 lung lung NN cord-304556-1f47gvys 204 47 diseases disease NNS cord-304556-1f47gvys 204 48 and and CC cord-304556-1f47gvys 204 49 , , , cord-304556-1f47gvys 204 50 if if IN cord-304556-1f47gvys 204 51 so so RB cord-304556-1f47gvys 204 52 , , , cord-304556-1f47gvys 204 53 how how WRB cord-304556-1f47gvys 204 54 they -PRON- PRP cord-304556-1f47gvys 204 55 can can MD cord-304556-1f47gvys 204 56 be be VB cord-304556-1f47gvys 204 57 manipulated manipulate VBN cord-304556-1f47gvys 204 58 in in IN cord-304556-1f47gvys 204 59 the the DT cord-304556-1f47gvys 204 60 clinic clinic NN cord-304556-1f47gvys 204 61 by by IN cord-304556-1f47gvys 204 62 specific specific JJ cord-304556-1f47gvys 204 63 modulators modulator NNS cord-304556-1f47gvys 204 64 of of IN cord-304556-1f47gvys 204 65 PtdSer ptdser JJ cord-304556-1f47gvys 204 66 recognition recognition NN cord-304556-1f47gvys 204 67 receptors receptor NNS cord-304556-1f47gvys 204 68 . . . cord-304556-1f47gvys 205 1 While while IN cord-304556-1f47gvys 205 2 in in IN cord-304556-1f47gvys 205 3 sterile sterile JJ cord-304556-1f47gvys 205 4 inflammation inflammation NN cord-304556-1f47gvys 205 5 recognition recognition NN cord-304556-1f47gvys 205 6 of of IN cord-304556-1f47gvys 205 7 apoptotic apoptotic JJ cord-304556-1f47gvys 205 8 cells cell NNS cord-304556-1f47gvys 205 9 by by IN cord-304556-1f47gvys 205 10 the the DT cord-304556-1f47gvys 205 11 immune immune JJ cord-304556-1f47gvys 205 12 system system NN cord-304556-1f47gvys 205 13 typically typically RB cord-304556-1f47gvys 205 14 results result VBZ cord-304556-1f47gvys 205 15 in in IN cord-304556-1f47gvys 205 16 suppression suppression NN cord-304556-1f47gvys 205 17 of of IN cord-304556-1f47gvys 205 18 the the DT cord-304556-1f47gvys 205 19 ongoing ongoing JJ cord-304556-1f47gvys 205 20 inflammatory inflammatory JJ cord-304556-1f47gvys 205 21 response response NN cord-304556-1f47gvys 205 22 , , , cord-304556-1f47gvys 205 23 the the DT cord-304556-1f47gvys 205 24 complexity complexity NN cord-304556-1f47gvys 205 25 of of IN cord-304556-1f47gvys 205 26 this this DT cord-304556-1f47gvys 205 27 process process NN cord-304556-1f47gvys 205 28 and and CC cord-304556-1f47gvys 205 29 its -PRON- PRP$ cord-304556-1f47gvys 205 30 biological biological JJ cord-304556-1f47gvys 205 31 effects effect NNS cord-304556-1f47gvys 205 32 greatly greatly RB cord-304556-1f47gvys 205 33 increase increase VBP cord-304556-1f47gvys 205 34 in in IN cord-304556-1f47gvys 205 35 the the DT cord-304556-1f47gvys 205 36 context context NN cord-304556-1f47gvys 205 37 of of IN cord-304556-1f47gvys 205 38 microbial microbial JJ cord-304556-1f47gvys 205 39 infections infection NNS cord-304556-1f47gvys 205 40 . . . cord-304556-1f47gvys 206 1 First first RB cord-304556-1f47gvys 206 2 , , , cord-304556-1f47gvys 206 3 some some DT cord-304556-1f47gvys 206 4 enveloped envelop VBN cord-304556-1f47gvys 206 5 viruses virus NNS cord-304556-1f47gvys 206 6 use use VBP cord-304556-1f47gvys 206 7 PtdSer ptdser JJ cord-304556-1f47gvys 206 8 receptors receptor NNS cord-304556-1f47gvys 206 9 to to TO cord-304556-1f47gvys 206 10 promote promote VB cord-304556-1f47gvys 206 11 their -PRON- PRP$ cord-304556-1f47gvys 206 12 entry entry NN cord-304556-1f47gvys 206 13 into into IN cord-304556-1f47gvys 206 14 the the DT cord-304556-1f47gvys 206 15 host host NN cord-304556-1f47gvys 206 16 cells cell NNS cord-304556-1f47gvys 206 17 and and CC cord-304556-1f47gvys 206 18 facilitate facilitate VBP cord-304556-1f47gvys 206 19 infection infection NN cord-304556-1f47gvys 206 20 and and CC cord-304556-1f47gvys 206 21 immune immune JJ cord-304556-1f47gvys 206 22 evasion evasion NN cord-304556-1f47gvys 206 23 [ [ -LRB- cord-304556-1f47gvys 206 24 115 115 CD cord-304556-1f47gvys 206 25 ] ] -RRB- cord-304556-1f47gvys 206 26 . . . cord-304556-1f47gvys 207 1 The the DT cord-304556-1f47gvys 207 2 interaction interaction NN cord-304556-1f47gvys 207 3 between between IN cord-304556-1f47gvys 207 4 PtdSer PtdSer NNP cord-304556-1f47gvys 207 5 exposed expose VBN cord-304556-1f47gvys 207 6 on on IN cord-304556-1f47gvys 207 7 the the DT cord-304556-1f47gvys 207 8 surface surface NN cord-304556-1f47gvys 207 9 of of IN cord-304556-1f47gvys 207 10 the the DT cord-304556-1f47gvys 207 11 viral viral JJ cord-304556-1f47gvys 207 12 envelope envelope NN cord-304556-1f47gvys 207 13 and and CC cord-304556-1f47gvys 207 14 members member NNS cord-304556-1f47gvys 207 15 of of IN cord-304556-1f47gvys 207 16 the the DT cord-304556-1f47gvys 207 17 TAM TAM NNP cord-304556-1f47gvys 207 18 and and CC cord-304556-1f47gvys 207 19 TIM TIM NNP cord-304556-1f47gvys 207 20 receptor receptor NN cord-304556-1f47gvys 207 21 families family NNS cord-304556-1f47gvys 207 22 expressed express VBD cord-304556-1f47gvys 207 23 on on IN cord-304556-1f47gvys 207 24 the the DT cord-304556-1f47gvys 207 25 target target NN cord-304556-1f47gvys 207 26 cell cell NN cord-304556-1f47gvys 207 27 enables enable VBZ cord-304556-1f47gvys 207 28 proximity proximity NN cord-304556-1f47gvys 207 29 to to IN cord-304556-1f47gvys 207 30 specific specific JJ cord-304556-1f47gvys 207 31 entry entry NN cord-304556-1f47gvys 207 32 receptors receptor NNS cord-304556-1f47gvys 207 33 and and CC cord-304556-1f47gvys 207 34 enhances enhance VBZ cord-304556-1f47gvys 207 35 engulfment engulfment NN cord-304556-1f47gvys 207 36 of of IN cord-304556-1f47gvys 207 37 the the DT cord-304556-1f47gvys 207 38 virus virus NN cord-304556-1f47gvys 207 39 [ [ -LRB- cord-304556-1f47gvys 207 40 116 116 CD cord-304556-1f47gvys 207 41 ] ] -RRB- cord-304556-1f47gvys 207 42 ( ( -LRB- cord-304556-1f47gvys 207 43 Fig Fig NNP cord-304556-1f47gvys 207 44 . . . cord-304556-1f47gvys 207 45 1c 1c CD cord-304556-1f47gvys 207 46 ) ) -RRB- cord-304556-1f47gvys 207 47 . . . cord-304556-1f47gvys 208 1 The the DT cord-304556-1f47gvys 208 2 relevance relevance NN cord-304556-1f47gvys 208 3 of of IN cord-304556-1f47gvys 208 4 this this DT cord-304556-1f47gvys 208 5 process process NN cord-304556-1f47gvys 208 6 , , , cord-304556-1f47gvys 208 7 called call VBN cord-304556-1f47gvys 208 8 ' ' `` cord-304556-1f47gvys 208 9 apoptotic apoptotic JJ cord-304556-1f47gvys 208 10 mimicry mimicry NN cord-304556-1f47gvys 208 11 ' ' '' cord-304556-1f47gvys 208 12 , , , cord-304556-1f47gvys 208 13 has have VBZ cord-304556-1f47gvys 208 14 recently recently RB cord-304556-1f47gvys 208 15 been be VBN cord-304556-1f47gvys 208 16 confirmed confirm VBN cord-304556-1f47gvys 208 17 for for IN cord-304556-1f47gvys 208 18 a a DT cord-304556-1f47gvys 208 19 broad broad JJ cord-304556-1f47gvys 208 20 range range NN cord-304556-1f47gvys 208 21 of of IN cord-304556-1f47gvys 208 22 virions virion NNS cord-304556-1f47gvys 208 23 , , , cord-304556-1f47gvys 208 24 including include VBG cord-304556-1f47gvys 208 25 Ebola Ebola NNP cord-304556-1f47gvys 208 26 and and CC cord-304556-1f47gvys 208 27 dengue dengue NN cord-304556-1f47gvys 208 28 viruses virus NNS cord-304556-1f47gvys 208 29 [ [ -LRB- cord-304556-1f47gvys 208 30 117 117 CD cord-304556-1f47gvys 208 31 , , , cord-304556-1f47gvys 208 32 118 118 CD cord-304556-1f47gvys 208 33 ] ] -RRB- cord-304556-1f47gvys 208 34 . . . cord-304556-1f47gvys 209 1 Thus thus RB cord-304556-1f47gvys 209 2 far far RB cord-304556-1f47gvys 209 3 , , , cord-304556-1f47gvys 209 4 however however RB cord-304556-1f47gvys 209 5 , , , cord-304556-1f47gvys 209 6 little little JJ cord-304556-1f47gvys 209 7 is be VBZ cord-304556-1f47gvys 209 8 known know VBN cord-304556-1f47gvys 209 9 about about IN cord-304556-1f47gvys 209 10 potential potential JJ cord-304556-1f47gvys 209 11 roles role NNS cord-304556-1f47gvys 209 12 of of IN cord-304556-1f47gvys 209 13 this this DT cord-304556-1f47gvys 209 14 entry entry NN cord-304556-1f47gvys 209 15 mechanism mechanism NN cord-304556-1f47gvys 209 16 in in IN cord-304556-1f47gvys 209 17 pulmonary pulmonary JJ cord-304556-1f47gvys 209 18 viral viral JJ cord-304556-1f47gvys 209 19 infections infection NNS cord-304556-1f47gvys 209 20 . . . cord-304556-1f47gvys 210 1 The the DT cord-304556-1f47gvys 210 2 observation observation NN cord-304556-1f47gvys 210 3 that that IN cord-304556-1f47gvys 210 4 the the DT cord-304556-1f47gvys 210 5 kinetics kinetic NNS cord-304556-1f47gvys 210 6 of of IN cord-304556-1f47gvys 210 7 influenza influenza NN cord-304556-1f47gvys 210 8 H1N1 H1N1 NNP cord-304556-1f47gvys 210 9 virus virus NN cord-304556-1f47gvys 210 10 clearance clearance NN cord-304556-1f47gvys 210 11 was be VBD cord-304556-1f47gvys 210 12 unaffected unaffected JJ cord-304556-1f47gvys 210 13 in in IN cord-304556-1f47gvys 210 14 Axldeficient Axldeficient NNP cord-304556-1f47gvys 210 15 mice mouse NNS cord-304556-1f47gvys 210 16 indirectly indirectly RB cord-304556-1f47gvys 210 17 indicates indicate VBZ cord-304556-1f47gvys 210 18 that that IN cord-304556-1f47gvys 210 19 Axl Axl NNP cord-304556-1f47gvys 210 20 is be VBZ cord-304556-1f47gvys 210 21 not not RB cord-304556-1f47gvys 210 22 important important JJ cord-304556-1f47gvys 210 23 for for IN cord-304556-1f47gvys 210 24 control control NN cord-304556-1f47gvys 210 25 of of IN cord-304556-1f47gvys 210 26 this this DT cord-304556-1f47gvys 210 27 infection infection NN cord-304556-1f47gvys 210 28 [ [ -LRB- cord-304556-1f47gvys 210 29 2 2 CD cord-304556-1f47gvys 210 30 ] ] -RRB- cord-304556-1f47gvys 210 31 , , , cord-304556-1f47gvys 210 32 though though IN cord-304556-1f47gvys 210 33 Axl Axl NNP cord-304556-1f47gvys 210 34 - - HYPH cord-304556-1f47gvys 210 35 H1N1 H1N1 NNP cord-304556-1f47gvys 210 36 interaction interaction NN cord-304556-1f47gvys 210 37 has have VBZ cord-304556-1f47gvys 210 38 not not RB cord-304556-1f47gvys 210 39 been be VBN cord-304556-1f47gvys 210 40 formally formally RB cord-304556-1f47gvys 210 41 tested test VBN cord-304556-1f47gvys 210 42 . . . cord-304556-1f47gvys 211 1 Similarly similarly RB cord-304556-1f47gvys 211 2 , , , cord-304556-1f47gvys 211 3 although although IN cord-304556-1f47gvys 211 4 TIM1 TIM1 NNP cord-304556-1f47gvys 211 5 promotes promote VBZ cord-304556-1f47gvys 211 6 internalisation internalisation NN cord-304556-1f47gvys 211 7 and and CC cord-304556-1f47gvys 211 8 replication replication NN cord-304556-1f47gvys 211 9 of of IN cord-304556-1f47gvys 211 10 several several JJ cord-304556-1f47gvys 211 11 enveloped envelop VBN cord-304556-1f47gvys 211 12 viruses virus NNS cord-304556-1f47gvys 211 13 , , , cord-304556-1f47gvys 211 14 TIM1-mediated tim1-mediated JJ cord-304556-1f47gvys 211 15 entry entry NN cord-304556-1f47gvys 211 16 does do VBZ cord-304556-1f47gvys 211 17 not not RB cord-304556-1f47gvys 211 18 lead lead VB cord-304556-1f47gvys 211 19 to to IN cord-304556-1f47gvys 211 20 a a DT cord-304556-1f47gvys 211 21 productive productive JJ cord-304556-1f47gvys 211 22 infection infection NN cord-304556-1f47gvys 211 23 by by IN cord-304556-1f47gvys 211 24 influenza influenza NN cord-304556-1f47gvys 211 25 H7N1 H7N1 NNP cord-304556-1f47gvys 211 26 and and CC cord-304556-1f47gvys 211 27 severe severe JJ cord-304556-1f47gvys 211 28 acute acute JJ cord-304556-1f47gvys 211 29 respiratory respiratory JJ cord-304556-1f47gvys 211 30 syndrome syndrome NN cord-304556-1f47gvys 211 31 ( ( -LRB- cord-304556-1f47gvys 211 32 SARS SARS NNP cord-304556-1f47gvys 211 33 ) ) -RRB- cord-304556-1f47gvys 211 34 coronavirus coronavirus NN cord-304556-1f47gvys 211 35 [ [ -LRB- cord-304556-1f47gvys 211 36 117 117 CD cord-304556-1f47gvys 211 37 ] ] -RRB- cord-304556-1f47gvys 211 38 , , , cord-304556-1f47gvys 211 39 arguing argue VBG cord-304556-1f47gvys 211 40 against against IN cord-304556-1f47gvys 211 41 an an DT cord-304556-1f47gvys 211 42 important important JJ cord-304556-1f47gvys 211 43 role role NN cord-304556-1f47gvys 211 44 of of IN cord-304556-1f47gvys 211 45 apoptotic apoptotic JJ cord-304556-1f47gvys 211 46 mimicry mimicry NN cord-304556-1f47gvys 211 47 in in IN cord-304556-1f47gvys 211 48 viral viral JJ cord-304556-1f47gvys 211 49 lung lung NN cord-304556-1f47gvys 211 50 diseases disease NNS cord-304556-1f47gvys 211 51 . . . cord-304556-1f47gvys 212 1 Second second RB cord-304556-1f47gvys 212 2 , , , cord-304556-1f47gvys 212 3 many many JJ cord-304556-1f47gvys 212 4 pathogens pathogen NNS cord-304556-1f47gvys 212 5 survive survive VBP cord-304556-1f47gvys 212 6 intracellularly intracellularly RB cord-304556-1f47gvys 212 7 , , , cord-304556-1f47gvys 212 8 and and CC cord-304556-1f47gvys 212 9 phagocytosis phagocytosis NN cord-304556-1f47gvys 212 10 of of IN cord-304556-1f47gvys 212 11 infected infected JJ cord-304556-1f47gvys 212 12 host host NN cord-304556-1f47gvys 212 13 cells cell NNS cord-304556-1f47gvys 212 14 undergoing undergo VBG cord-304556-1f47gvys 212 15 apoptosis apoptosis NN cord-304556-1f47gvys 212 16 has have VBZ cord-304556-1f47gvys 212 17 diverse diverse JJ cord-304556-1f47gvys 212 18 consequences consequence NNS cord-304556-1f47gvys 212 19 for for IN cord-304556-1f47gvys 212 20 pathogen pathogen NN cord-304556-1f47gvys 212 21 survival survival NN cord-304556-1f47gvys 212 22 and and CC cord-304556-1f47gvys 212 23 immune immune JJ cord-304556-1f47gvys 212 24 response response NN cord-304556-1f47gvys 212 25 of of IN cord-304556-1f47gvys 212 26 the the DT cord-304556-1f47gvys 212 27 host host NN cord-304556-1f47gvys 212 28 [ [ -LRB- cord-304556-1f47gvys 212 29 119 119 CD cord-304556-1f47gvys 212 30 ] ] -RRB- cord-304556-1f47gvys 212 31 . . . cord-304556-1f47gvys 213 1 One one CD cord-304556-1f47gvys 213 2 of of IN cord-304556-1f47gvys 213 3 the the DT cord-304556-1f47gvys 213 4 main main JJ cord-304556-1f47gvys 213 5 strategies strategy NNS cord-304556-1f47gvys 213 6 of of IN cord-304556-1f47gvys 213 7 the the DT cord-304556-1f47gvys 213 8 immune immune JJ cord-304556-1f47gvys 213 9 system system NN cord-304556-1f47gvys 213 10 to to TO cord-304556-1f47gvys 213 11 control control VB cord-304556-1f47gvys 213 12 intracellular intracellular JJ cord-304556-1f47gvys 213 13 infections infection NNS cord-304556-1f47gvys 213 14 is be VBZ cord-304556-1f47gvys 213 15 through through IN cord-304556-1f47gvys 213 16 induction induction NN cord-304556-1f47gvys 213 17 of of IN cord-304556-1f47gvys 213 18 apoptosis apoptosis NN cord-304556-1f47gvys 213 19 of of IN cord-304556-1f47gvys 213 20 infected infected JJ cord-304556-1f47gvys 213 21 cells cell NNS cord-304556-1f47gvys 213 22 , , , cord-304556-1f47gvys 213 23 which which WDT cord-304556-1f47gvys 213 24 are be VBP cord-304556-1f47gvys 213 25 then then RB cord-304556-1f47gvys 213 26 engulfed engulf VBN cord-304556-1f47gvys 213 27 and and CC cord-304556-1f47gvys 213 28 destroyed destroy VBN cord-304556-1f47gvys 213 29 together together RB cord-304556-1f47gvys 213 30 with with IN cord-304556-1f47gvys 213 31 the the DT cord-304556-1f47gvys 213 32 pathogen pathogen NN cord-304556-1f47gvys 213 33 by by IN cord-304556-1f47gvys 213 34 phagocytes phagocyte NNS cord-304556-1f47gvys 213 35 ( ( -LRB- cord-304556-1f47gvys 213 36 Fig Fig NNP cord-304556-1f47gvys 213 37 . . . cord-304556-1f47gvys 213 38 1d 1d CD cord-304556-1f47gvys 213 39 ) ) -RRB- cord-304556-1f47gvys 213 40 . . . cord-304556-1f47gvys 214 1 However however RB cord-304556-1f47gvys 214 2 , , , cord-304556-1f47gvys 214 3 in in IN cord-304556-1f47gvys 214 4 some some DT cord-304556-1f47gvys 214 5 cases case NNS cord-304556-1f47gvys 214 6 , , , cord-304556-1f47gvys 214 7 efferocytosis efferocytosis NN cord-304556-1f47gvys 214 8 of of IN cord-304556-1f47gvys 214 9 infected infected JJ cord-304556-1f47gvys 214 10 cells cell NNS cord-304556-1f47gvys 214 11 is be VBZ cord-304556-1f47gvys 214 12 used use VBN cord-304556-1f47gvys 214 13 by by IN cord-304556-1f47gvys 214 14 intracellular intracellular JJ cord-304556-1f47gvys 214 15 pathogens pathogen NNS cord-304556-1f47gvys 214 16 , , , cord-304556-1f47gvys 214 17 such such JJ cord-304556-1f47gvys 214 18 as as IN cord-304556-1f47gvys 214 19 the the DT cord-304556-1f47gvys 214 20 parasite parasite NN cord-304556-1f47gvys 214 21 Leishmania Leishmania NNP cord-304556-1f47gvys 214 22 major major NN cord-304556-1f47gvys 214 23 , , , cord-304556-1f47gvys 214 24 to to TO cord-304556-1f47gvys 214 25 evade evade VB cord-304556-1f47gvys 214 26 the the DT cord-304556-1f47gvys 214 27 immune immune JJ cord-304556-1f47gvys 214 28 response response NN cord-304556-1f47gvys 214 29 and and CC cord-304556-1f47gvys 214 30 gain gain VB cord-304556-1f47gvys 214 31 entry entry NN cord-304556-1f47gvys 214 32 into into IN cord-304556-1f47gvys 214 33 the the DT cord-304556-1f47gvys 214 34 new new JJ cord-304556-1f47gvys 214 35 cellular cellular JJ cord-304556-1f47gvys 214 36 host host NN cord-304556-1f47gvys 214 37 [ [ -LRB- cord-304556-1f47gvys 214 38 119 119 CD cord-304556-1f47gvys 214 39 ] ] -RRB- cord-304556-1f47gvys 214 40 . . . cord-304556-1f47gvys 215 1 Among among IN cord-304556-1f47gvys 215 2 pathogens pathogen NNS cord-304556-1f47gvys 215 3 important important JJ cord-304556-1f47gvys 215 4 in in IN cord-304556-1f47gvys 215 5 respiratory respiratory JJ cord-304556-1f47gvys 215 6 diseases disease NNS cord-304556-1f47gvys 215 7 , , , cord-304556-1f47gvys 215 8 the the DT cord-304556-1f47gvys 215 9 role role NN cord-304556-1f47gvys 215 10 of of IN cord-304556-1f47gvys 215 11 efferocytosis efferocytosis NN cord-304556-1f47gvys 215 12 has have VBZ cord-304556-1f47gvys 215 13 been be VBN cord-304556-1f47gvys 215 14 most most RBS cord-304556-1f47gvys 215 15 thoroughly thoroughly RB cord-304556-1f47gvys 215 16 studied study VBN cord-304556-1f47gvys 215 17 in in IN cord-304556-1f47gvys 215 18 the the DT cord-304556-1f47gvys 215 19 context context NN cord-304556-1f47gvys 215 20 of of IN cord-304556-1f47gvys 215 21 Mycobacterium Mycobacterium NNP cord-304556-1f47gvys 215 22 tuberculosis tuberculosis NN cord-304556-1f47gvys 215 23 infections infection NNS cord-304556-1f47gvys 215 24 . . . cord-304556-1f47gvys 216 1 M. M. NNP cord-304556-1f47gvys 216 2 tuberculosis tuberculosis NN cord-304556-1f47gvys 216 3 infects infect VBZ cord-304556-1f47gvys 216 4 macrophages macrophage NNS cord-304556-1f47gvys 216 5 and and CC cord-304556-1f47gvys 216 6 induces induce VBZ cord-304556-1f47gvys 216 7 necrosis necrosis NN cord-304556-1f47gvys 216 8 of of IN cord-304556-1f47gvys 216 9 the the DT cord-304556-1f47gvys 216 10 host host NN cord-304556-1f47gvys 216 11 cell cell NN cord-304556-1f47gvys 216 12 to to TO cord-304556-1f47gvys 216 13 avoid avoid VB cord-304556-1f47gvys 216 14 clearance clearance NN cord-304556-1f47gvys 216 15 by by IN cord-304556-1f47gvys 216 16 the the DT cord-304556-1f47gvys 216 17 immune immune JJ cord-304556-1f47gvys 216 18 system system NN cord-304556-1f47gvys 216 19 and and CC cord-304556-1f47gvys 216 20 disseminate disseminate VB cord-304556-1f47gvys 216 21 [ [ -LRB- cord-304556-1f47gvys 216 22 120 120 CD cord-304556-1f47gvys 216 23 ] ] -RRB- cord-304556-1f47gvys 216 24 . . . cord-304556-1f47gvys 217 1 Interestingly interestingly RB cord-304556-1f47gvys 217 2 , , , cord-304556-1f47gvys 217 3 M. M. NNP cord-304556-1f47gvys 217 4 tuberculosis tuberculosis NN cord-304556-1f47gvys 217 5 - - HYPH cord-304556-1f47gvys 217 6 infected infect VBN cord-304556-1f47gvys 217 7 mouse mouse NN cord-304556-1f47gvys 217 8 macrophages macrophage NNS cord-304556-1f47gvys 217 9 which which WDT cord-304556-1f47gvys 217 10 die die VBP cord-304556-1f47gvys 217 11 by by IN cord-304556-1f47gvys 217 12 apoptosis apoptosis NN cord-304556-1f47gvys 217 13 are be VBP cord-304556-1f47gvys 217 14 rapidly rapidly RB cord-304556-1f47gvys 217 15 efferocytosed efferocytose VBN cord-304556-1f47gvys 217 16 by by IN cord-304556-1f47gvys 217 17 uninfected uninfected JJ cord-304556-1f47gvys 217 18 macrophages macrophage NNS cord-304556-1f47gvys 217 19 , , , cord-304556-1f47gvys 217 20 leading lead VBG cord-304556-1f47gvys 217 21 to to IN cord-304556-1f47gvys 217 22 bacterial bacterial JJ cord-304556-1f47gvys 217 23 killing killing NN cord-304556-1f47gvys 217 24 and and CC cord-304556-1f47gvys 217 25 elimination elimination NN cord-304556-1f47gvys 217 26 [ [ -LRB- cord-304556-1f47gvys 217 27 121 121 CD cord-304556-1f47gvys 217 28 ] ] -RRB- cord-304556-1f47gvys 217 29 . . . cord-304556-1f47gvys 218 1 This this DT cord-304556-1f47gvys 218 2 bactericidal bactericidal JJ cord-304556-1f47gvys 218 3 effect effect NN cord-304556-1f47gvys 218 4 is be VBZ cord-304556-1f47gvys 218 5 dependent dependent JJ cord-304556-1f47gvys 218 6 on on IN cord-304556-1f47gvys 218 7 efferocytosis efferocytosis NN cord-304556-1f47gvys 218 8 , , , cord-304556-1f47gvys 218 9 as as IN cord-304556-1f47gvys 218 10 the the DT cord-304556-1f47gvys 218 11 uptake uptake NN cord-304556-1f47gvys 218 12 of of IN cord-304556-1f47gvys 218 13 naked naked JJ cord-304556-1f47gvys 218 14 M. M. NNP cord-304556-1f47gvys 218 15 tuberculosis tuberculosis NN cord-304556-1f47gvys 218 16 does do VBZ cord-304556-1f47gvys 218 17 not not RB cord-304556-1f47gvys 218 18 allow allow VB cord-304556-1f47gvys 218 19 for for IN cord-304556-1f47gvys 218 20 lysosome lysosome NN cord-304556-1f47gvys 218 21 recruitment recruitment NN cord-304556-1f47gvys 218 22 to to IN cord-304556-1f47gvys 218 23 the the DT cord-304556-1f47gvys 218 24 bacteriacontaining bacteriacontaining NNP cord-304556-1f47gvys 218 25 phagosome phagosome NNP cord-304556-1f47gvys 218 26 , , , cord-304556-1f47gvys 218 27 and and CC cord-304556-1f47gvys 218 28 inhibition inhibition NN cord-304556-1f47gvys 218 29 of of IN cord-304556-1f47gvys 218 30 apoptotic apoptotic JJ cord-304556-1f47gvys 218 31 cell cell NN cord-304556-1f47gvys 218 32 uptake uptake NN cord-304556-1f47gvys 218 33 with with IN cord-304556-1f47gvys 218 34 a a DT cord-304556-1f47gvys 218 35 TIM-4-blocking tim-4-blocke VBG cord-304556-1f47gvys 218 36 antibody antibody NN cord-304556-1f47gvys 218 37 prevents prevent VBZ cord-304556-1f47gvys 218 38 bacterial bacterial JJ cord-304556-1f47gvys 218 39 control control NN cord-304556-1f47gvys 218 40 in in IN cord-304556-1f47gvys 218 41 vitro vitro FW cord-304556-1f47gvys 218 42 and and CC cord-304556-1f47gvys 218 43 increases increase VBZ cord-304556-1f47gvys 218 44 bacterial bacterial JJ cord-304556-1f47gvys 218 45 burden burden NN cord-304556-1f47gvys 218 46 in in IN cord-304556-1f47gvys 218 47 the the DT cord-304556-1f47gvys 218 48 lungs lung NNS cord-304556-1f47gvys 218 49 in in IN cord-304556-1f47gvys 218 50 vivo vivo NN cord-304556-1f47gvys 218 51 [ [ -LRB- cord-304556-1f47gvys 218 52 121 121 CD cord-304556-1f47gvys 218 53 ] ] -RRB- cord-304556-1f47gvys 218 54 . . . cord-304556-1f47gvys 219 1 The the DT cord-304556-1f47gvys 219 2 observation observation NN cord-304556-1f47gvys 219 3 that that IN cord-304556-1f47gvys 219 4 bactericidal bactericidal JJ cord-304556-1f47gvys 219 5 activity activity NN cord-304556-1f47gvys 219 6 of of IN cord-304556-1f47gvys 219 7 macrophages macrophage NNS cord-304556-1f47gvys 219 8 infected infect VBN cord-304556-1f47gvys 219 9 with with IN cord-304556-1f47gvys 219 10 Streptococcus streptococcus NN cord-304556-1f47gvys 219 11 pneumoniae pneumoniae NN cord-304556-1f47gvys 219 12 is be VBZ cord-304556-1f47gvys 219 13 dependent dependent JJ cord-304556-1f47gvys 219 14 on on IN cord-304556-1f47gvys 219 15 induction induction NN cord-304556-1f47gvys 219 16 of of IN cord-304556-1f47gvys 219 17 macrophage macrophage NN cord-304556-1f47gvys 219 18 apoptosis apoptosis NN cord-304556-1f47gvys 219 19 suggests suggest VBZ cord-304556-1f47gvys 219 20 that that IN cord-304556-1f47gvys 219 21 a a DT cord-304556-1f47gvys 219 22 similar similar JJ cord-304556-1f47gvys 219 23 mechanism mechanism NN cord-304556-1f47gvys 219 24 might may MD cord-304556-1f47gvys 219 25 be be VB cord-304556-1f47gvys 219 26 involved involve VBN cord-304556-1f47gvys 219 27 in in IN cord-304556-1f47gvys 219 28 controlling control VBG cord-304556-1f47gvys 219 29 infection infection NN cord-304556-1f47gvys 219 30 with with IN cord-304556-1f47gvys 219 31 this this DT cord-304556-1f47gvys 219 32 bacterium bacterium NN cord-304556-1f47gvys 219 33 [ [ -LRB- cord-304556-1f47gvys 219 34 122 122 CD cord-304556-1f47gvys 219 35 ] ] -RRB- cord-304556-1f47gvys 219 36 , , , cord-304556-1f47gvys 219 37 though though IN cord-304556-1f47gvys 219 38 the the DT cord-304556-1f47gvys 219 39 involvement involvement NN cord-304556-1f47gvys 219 40 of of IN cord-304556-1f47gvys 219 41 efferocytosis efferocytosis NN cord-304556-1f47gvys 219 42 in in IN cord-304556-1f47gvys 219 43 this this DT cord-304556-1f47gvys 219 44 process process NN cord-304556-1f47gvys 219 45 has have VBZ cord-304556-1f47gvys 219 46 not not RB cord-304556-1f47gvys 219 47 been be VBN cord-304556-1f47gvys 219 48 formally formally RB cord-304556-1f47gvys 219 49 proven prove VBN cord-304556-1f47gvys 219 50 . . . cord-304556-1f47gvys 220 1 Engulfment engulfment NN cord-304556-1f47gvys 220 2 of of IN cord-304556-1f47gvys 220 3 macrophage macrophage NN cord-304556-1f47gvys 220 4 - - HYPH cord-304556-1f47gvys 220 5 derived derive VBN cord-304556-1f47gvys 220 6 apoptotic apoptotic JJ cord-304556-1f47gvys 220 7 vesicles vesicle NNS cord-304556-1f47gvys 220 8 also also RB cord-304556-1f47gvys 220 9 plays play VBZ cord-304556-1f47gvys 220 10 a a DT cord-304556-1f47gvys 220 11 critical critical JJ cord-304556-1f47gvys 220 12 , , , cord-304556-1f47gvys 220 13 though though IN cord-304556-1f47gvys 220 14 indirect indirect JJ cord-304556-1f47gvys 220 15 , , , cord-304556-1f47gvys 220 16 role role NN cord-304556-1f47gvys 220 17 in in IN cord-304556-1f47gvys 220 18 the the DT cord-304556-1f47gvys 220 19 adaptive adaptive JJ cord-304556-1f47gvys 220 20 immune immune JJ cord-304556-1f47gvys 220 21 response response NN cord-304556-1f47gvys 220 22 against against IN cord-304556-1f47gvys 220 23 M. M. NNP cord-304556-1f47gvys 220 24 tuberculosis tuberculosis NN cord-304556-1f47gvys 220 25 : : : cord-304556-1f47gvys 221 1 annexin annexin NNP cord-304556-1f47gvys 221 2 A1-dependent a1-dependent IN cord-304556-1f47gvys 221 3 uptake uptake NN cord-304556-1f47gvys 221 4 of of IN cord-304556-1f47gvys 221 5 apoptotic apoptotic JJ cord-304556-1f47gvys 221 6 cells cell NNS cord-304556-1f47gvys 221 7 by by IN cord-304556-1f47gvys 221 8 dendritic dendritic JJ cord-304556-1f47gvys 221 9 cells cell NNS cord-304556-1f47gvys 221 10 is be VBZ cord-304556-1f47gvys 221 11 required require VBN cord-304556-1f47gvys 221 12 for for IN cord-304556-1f47gvys 221 13 cross cross JJ cord-304556-1f47gvys 221 14 - - JJ cord-304556-1f47gvys 221 15 presentation presentation NN cord-304556-1f47gvys 221 16 and and CC cord-304556-1f47gvys 221 17 generation generation NN cord-304556-1f47gvys 221 18 of of IN cord-304556-1f47gvys 221 19 M. M. NNP cord-304556-1f47gvys 221 20 tuberculosis tuberculosis NN cord-304556-1f47gvys 221 21 - - HYPH cord-304556-1f47gvys 221 22 specific specific JJ cord-304556-1f47gvys 221 23 CD8 CD8 NNP cord-304556-1f47gvys 221 24 T T NNP cord-304556-1f47gvys 221 25 cell cell NN cord-304556-1f47gvys 221 26 response response NN cord-304556-1f47gvys 221 27 and and CC cord-304556-1f47gvys 221 28 bacterial bacterial JJ cord-304556-1f47gvys 221 29 clearance clearance NN cord-304556-1f47gvys 221 30 from from IN cord-304556-1f47gvys 221 31 the the DT cord-304556-1f47gvys 221 32 lung lung NN cord-304556-1f47gvys 221 33 [ [ -LRB- cord-304556-1f47gvys 221 34 123 123 CD cord-304556-1f47gvys 221 35 ] ] -RRB- cord-304556-1f47gvys 221 36 . . . cord-304556-1f47gvys 222 1 The the DT cord-304556-1f47gvys 222 2 antimicrobial antimicrobial JJ cord-304556-1f47gvys 222 3 role role NN cord-304556-1f47gvys 222 4 of of IN cord-304556-1f47gvys 222 5 apoptotic apoptotic JJ cord-304556-1f47gvys 222 6 cell cell NN cord-304556-1f47gvys 222 7 clearance clearance NN cord-304556-1f47gvys 222 8 in in IN cord-304556-1f47gvys 222 9 pulmonary pulmonary JJ cord-304556-1f47gvys 222 10 infections infection NNS cord-304556-1f47gvys 222 11 is be VBZ cord-304556-1f47gvys 222 12 not not RB cord-304556-1f47gvys 222 13 restricted restrict VBN cord-304556-1f47gvys 222 14 to to IN cord-304556-1f47gvys 222 15 bacteria bacteria NNS cord-304556-1f47gvys 222 16 as as IN cord-304556-1f47gvys 222 17 the the DT cord-304556-1f47gvys 222 18 influenza influenza NN cord-304556-1f47gvys 222 19 A a DT cord-304556-1f47gvys 222 20 virus virus NN cord-304556-1f47gvys 222 21 induces induce VBZ cord-304556-1f47gvys 222 22 apoptosis apoptosis NN cord-304556-1f47gvys 222 23 of of IN cord-304556-1f47gvys 222 24 epithelial epithelial JJ cord-304556-1f47gvys 222 25 cells cell NNS cord-304556-1f47gvys 222 26 upon upon IN cord-304556-1f47gvys 222 27 infection infection NN cord-304556-1f47gvys 222 28 and and CC cord-304556-1f47gvys 222 29 engulfment engulfment NN cord-304556-1f47gvys 222 30 of of IN cord-304556-1f47gvys 222 31 influenza influenza NN cord-304556-1f47gvys 222 32 A A NNP cord-304556-1f47gvys 222 33 - - HYPH cord-304556-1f47gvys 222 34 infected infect VBN cord-304556-1f47gvys 222 35 cells cell NNS cord-304556-1f47gvys 222 36 by by IN cord-304556-1f47gvys 222 37 macrophages macrophage NNS cord-304556-1f47gvys 222 38 is be VBZ cord-304556-1f47gvys 222 39 associated associate VBN cord-304556-1f47gvys 222 40 with with IN cord-304556-1f47gvys 222 41 reduction reduction NN cord-304556-1f47gvys 222 42 of of IN cord-304556-1f47gvys 222 43 viral viral JJ cord-304556-1f47gvys 222 44 titres titre NNS cord-304556-1f47gvys 222 45 [ [ -LRB- cord-304556-1f47gvys 222 46 124 124 CD cord-304556-1f47gvys 222 47 ] ] -RRB- cord-304556-1f47gvys 222 48 . . . cord-304556-1f47gvys 223 1 On on IN cord-304556-1f47gvys 223 2 the the DT cord-304556-1f47gvys 223 3 other other JJ cord-304556-1f47gvys 223 4 hand hand NN cord-304556-1f47gvys 223 5 , , , cord-304556-1f47gvys 223 6 infection infection NN cord-304556-1f47gvys 223 7 of of IN cord-304556-1f47gvys 223 8 macrophages macrophage NNS cord-304556-1f47gvys 223 9 with with IN cord-304556-1f47gvys 223 10 Francisella Francisella NNP cord-304556-1f47gvys 223 11 novicida novicida NNP cord-304556-1f47gvys 223 12 , , , cord-304556-1f47gvys 223 13 a a DT cord-304556-1f47gvys 223 14 member member NN cord-304556-1f47gvys 223 15 of of IN cord-304556-1f47gvys 223 16 the the DT cord-304556-1f47gvys 223 17 Francisellaceae Francisellaceae NNP cord-304556-1f47gvys 223 18 family family NN cord-304556-1f47gvys 223 19 of of IN cord-304556-1f47gvys 223 20 intracellular intracellular JJ cord-304556-1f47gvys 223 21 bacteria bacteria NNS cord-304556-1f47gvys 223 22 which which WDT cord-304556-1f47gvys 223 23 cause cause VBP cord-304556-1f47gvys 223 24 pulmonary pulmonary JJ cord-304556-1f47gvys 223 25 inflammation inflammation NN cord-304556-1f47gvys 223 26 associated associate VBN cord-304556-1f47gvys 223 27 with with IN cord-304556-1f47gvys 223 28 necrotic necrotic JJ cord-304556-1f47gvys 223 29 infiltrates infiltrate NNS cord-304556-1f47gvys 223 30 in in IN cord-304556-1f47gvys 223 31 the the DT cord-304556-1f47gvys 223 32 lung lung NN cord-304556-1f47gvys 223 33 , , , cord-304556-1f47gvys 223 34 reduces reduce VBZ cord-304556-1f47gvys 223 35 their -PRON- PRP$ cord-304556-1f47gvys 223 36 efferocytic efferocytic JJ cord-304556-1f47gvys 223 37 function function NN cord-304556-1f47gvys 223 38 , , , cord-304556-1f47gvys 223 39 potentially potentially RB cord-304556-1f47gvys 223 40 contributing contribute VBG cord-304556-1f47gvys 223 41 to to IN cord-304556-1f47gvys 223 42 the the DT cord-304556-1f47gvys 223 43 accumulation accumulation NN cord-304556-1f47gvys 223 44 of of IN cord-304556-1f47gvys 223 45 necrotic necrotic JJ cord-304556-1f47gvys 223 46 cell cell NN cord-304556-1f47gvys 223 47 debris debris NN cord-304556-1f47gvys 223 48 and and CC cord-304556-1f47gvys 223 49 exacerbation exacerbation NN cord-304556-1f47gvys 223 50 of of IN cord-304556-1f47gvys 223 51 disease disease NN cord-304556-1f47gvys 223 52 [ [ -LRB- cord-304556-1f47gvys 223 53 125 125 CD cord-304556-1f47gvys 223 54 ] ] -RRB- cord-304556-1f47gvys 223 55 . . . cord-304556-1f47gvys 224 1 Taken take VBN cord-304556-1f47gvys 224 2 together together RB cord-304556-1f47gvys 224 3 , , , cord-304556-1f47gvys 224 4 these these DT cord-304556-1f47gvys 224 5 studies study NNS cord-304556-1f47gvys 224 6 suggest suggest VBP cord-304556-1f47gvys 224 7 that that IN cord-304556-1f47gvys 224 8 efferocytosis efferocytosis NN cord-304556-1f47gvys 224 9 is be VBZ cord-304556-1f47gvys 224 10 not not RB cord-304556-1f47gvys 224 11 only only RB cord-304556-1f47gvys 224 12 a a DT cord-304556-1f47gvys 224 13 constitutive constitutive JJ cord-304556-1f47gvys 224 14 function function NN cord-304556-1f47gvys 224 15 of of IN cord-304556-1f47gvys 224 16 macrophages macrophage NNS cord-304556-1f47gvys 224 17 required require VBN cord-304556-1f47gvys 224 18 for for IN cord-304556-1f47gvys 224 19 maintaining maintain VBG cord-304556-1f47gvys 224 20 immune immune JJ cord-304556-1f47gvys 224 21 homeostasis homeostasis NN cord-304556-1f47gvys 224 22 in in IN cord-304556-1f47gvys 224 23 health health NN cord-304556-1f47gvys 224 24 and and CC cord-304556-1f47gvys 224 25 during during IN cord-304556-1f47gvys 224 26 inflammatory inflammatory JJ cord-304556-1f47gvys 224 27 response response NN cord-304556-1f47gvys 224 28 but but CC cord-304556-1f47gvys 224 29 also also RB cord-304556-1f47gvys 224 30 an an DT cord-304556-1f47gvys 224 31 important important JJ cord-304556-1f47gvys 224 32 antimicrobial antimicrobial JJ cord-304556-1f47gvys 224 33 effector effector NN cord-304556-1f47gvys 224 34 mechanism mechanism NN cord-304556-1f47gvys 224 35 . . . cord-304556-1f47gvys 225 1 However however RB cord-304556-1f47gvys 225 2 , , , cord-304556-1f47gvys 225 3 it -PRON- PRP cord-304556-1f47gvys 225 4 has have VBZ cord-304556-1f47gvys 225 5 to to TO cord-304556-1f47gvys 225 6 be be VB cord-304556-1f47gvys 225 7 noted note VBN cord-304556-1f47gvys 225 8 that that IN cord-304556-1f47gvys 225 9 apart apart RB cord-304556-1f47gvys 225 10 from from IN cord-304556-1f47gvys 225 11 bactericidal bactericidal JJ cord-304556-1f47gvys 225 12 activity activity NN cord-304556-1f47gvys 225 13 against against IN cord-304556-1f47gvys 225 14 specific specific JJ cord-304556-1f47gvys 225 15 pathogens pathogen NNS cord-304556-1f47gvys 225 16 , , , cord-304556-1f47gvys 225 17 the the DT cord-304556-1f47gvys 225 18 antiinflammatory antiinflammatory JJ cord-304556-1f47gvys 225 19 signal signal NN cord-304556-1f47gvys 225 20 associated associate VBN cord-304556-1f47gvys 225 21 with with IN cord-304556-1f47gvys 225 22 apoptotic apoptotic JJ cord-304556-1f47gvys 225 23 cell cell NN cord-304556-1f47gvys 225 24 uptake uptake NN cord-304556-1f47gvys 225 25 by by IN cord-304556-1f47gvys 225 26 phagocytes phagocyte NNS cord-304556-1f47gvys 225 27 might may MD cord-304556-1f47gvys 225 28 prevent prevent VB cord-304556-1f47gvys 225 29 the the DT cord-304556-1f47gvys 225 30 mounting mounting NN cord-304556-1f47gvys 225 31 of of IN cord-304556-1f47gvys 225 32 an an DT cord-304556-1f47gvys 225 33 efficient efficient JJ cord-304556-1f47gvys 225 34 immune immune JJ cord-304556-1f47gvys 225 35 response response NN cord-304556-1f47gvys 225 36 in in IN cord-304556-1f47gvys 225 37 the the DT cord-304556-1f47gvys 225 38 context context NN cord-304556-1f47gvys 225 39 of of IN cord-304556-1f47gvys 225 40 other other JJ cord-304556-1f47gvys 225 41 lung lung NN cord-304556-1f47gvys 225 42 infections infection NNS cord-304556-1f47gvys 225 43 . . . cord-304556-1f47gvys 226 1 Prior prior JJ cord-304556-1f47gvys 226 2 exposure exposure NN cord-304556-1f47gvys 226 3 of of IN cord-304556-1f47gvys 226 4 mouse mouse NN cord-304556-1f47gvys 226 5 airway airway NN cord-304556-1f47gvys 226 6 macrophages macrophage NNS cord-304556-1f47gvys 226 7 to to IN cord-304556-1f47gvys 226 8 apoptotic apoptotic JJ cord-304556-1f47gvys 226 9 cells cell NNS cord-304556-1f47gvys 226 10 results result NNS cord-304556-1f47gvys 226 11 in in IN cord-304556-1f47gvys 226 12 suppression suppression NN cord-304556-1f47gvys 226 13 of of IN cord-304556-1f47gvys 226 14 FcR fcr NN cord-304556-1f47gvys 226 15 - - HYPH cord-304556-1f47gvys 226 16 mediated mediate VBN cord-304556-1f47gvys 226 17 phagocytosis phagocytosis NN cord-304556-1f47gvys 226 18 and and CC cord-304556-1f47gvys 226 19 killing killing NN cord-304556-1f47gvys 226 20 of of IN cord-304556-1f47gvys 226 21 bacteria bacteria NNS cord-304556-1f47gvys 226 22 , , , cord-304556-1f47gvys 226 23 and and CC cord-304556-1f47gvys 226 24 intrapulmonary intrapulmonary JJ cord-304556-1f47gvys 226 25 administration administration NN cord-304556-1f47gvys 226 26 of of IN cord-304556-1f47gvys 226 27 apoptotic apoptotic JJ cord-304556-1f47gvys 226 28 cells cell NNS cord-304556-1f47gvys 226 29 causes cause VBZ cord-304556-1f47gvys 226 30 significant significant JJ cord-304556-1f47gvys 226 31 impairment impairment NN cord-304556-1f47gvys 226 32 of of IN cord-304556-1f47gvys 226 33 S. S. NNP cord-304556-1f47gvys 226 34 pneumoniae pneumoniae NN cord-304556-1f47gvys 226 35 clearance clearance NN cord-304556-1f47gvys 226 36 from from IN cord-304556-1f47gvys 226 37 the the DT cord-304556-1f47gvys 226 38 infected infected JJ cord-304556-1f47gvys 226 39 lung lung NN cord-304556-1f47gvys 226 40 [ [ -LRB- cord-304556-1f47gvys 226 41 56 56 CD cord-304556-1f47gvys 226 42 ] ] -RRB- cord-304556-1f47gvys 226 43 . . . cord-304556-1f47gvys 227 1 Suppression suppression NN cord-304556-1f47gvys 227 2 of of IN cord-304556-1f47gvys 227 3 antimicrobial antimicrobial JJ cord-304556-1f47gvys 227 4 responses response NNS cord-304556-1f47gvys 227 5 of of IN cord-304556-1f47gvys 227 6 airway airway NN cord-304556-1f47gvys 227 7 macrophages macrophage NNS cord-304556-1f47gvys 227 8 is be VBZ cord-304556-1f47gvys 227 9 also also RB cord-304556-1f47gvys 227 10 augmented augment VBN cord-304556-1f47gvys 227 11 by by IN cord-304556-1f47gvys 227 12 glucocorticoids glucocorticoid NNS cord-304556-1f47gvys 227 13 , , , cord-304556-1f47gvys 227 14 which which WDT cord-304556-1f47gvys 227 15 promote promote VBP cord-304556-1f47gvys 227 16 efferocytosis efferocytosis NN cord-304556-1f47gvys 227 17 , , , cord-304556-1f47gvys 227 18 and and CC cord-304556-1f47gvys 227 19 treatment treatment NN cord-304556-1f47gvys 227 20 of of IN cord-304556-1f47gvys 227 21 mice mouse NNS cord-304556-1f47gvys 227 22 with with IN cord-304556-1f47gvys 227 23 apoptotic apoptotic JJ cord-304556-1f47gvys 227 24 cells cell NNS cord-304556-1f47gvys 227 25 in in IN cord-304556-1f47gvys 227 26 the the DT cord-304556-1f47gvys 227 27 presence presence NN cord-304556-1f47gvys 227 28 of of IN cord-304556-1f47gvys 227 29 glucocorticoids glucocorticoid NNS cord-304556-1f47gvys 227 30 is be VBZ cord-304556-1f47gvys 227 31 associated associate VBN cord-304556-1f47gvys 227 32 with with IN cord-304556-1f47gvys 227 33 elevated elevated JJ cord-304556-1f47gvys 227 34 bacterial bacterial JJ cord-304556-1f47gvys 227 35 burden burden NN cord-304556-1f47gvys 227 36 in in IN cord-304556-1f47gvys 227 37 the the DT cord-304556-1f47gvys 227 38 lungs lung NNS cord-304556-1f47gvys 227 39 [ [ -LRB- cord-304556-1f47gvys 227 40 126 126 CD cord-304556-1f47gvys 227 41 ] ] -RRB- cord-304556-1f47gvys 227 42 . . . cord-304556-1f47gvys 228 1 Even even RB cord-304556-1f47gvys 228 2 though though IN cord-304556-1f47gvys 228 3 validation validation NN cord-304556-1f47gvys 228 4 of of IN cord-304556-1f47gvys 228 5 these these DT cord-304556-1f47gvys 228 6 observations observation NNS cord-304556-1f47gvys 228 7 in in IN cord-304556-1f47gvys 228 8 human human JJ cord-304556-1f47gvys 228 9 systems system NNS cord-304556-1f47gvys 228 10 is be VBZ cord-304556-1f47gvys 228 11 necessary necessary JJ cord-304556-1f47gvys 228 12 , , , cord-304556-1f47gvys 228 13 they -PRON- PRP cord-304556-1f47gvys 228 14 clearly clearly RB cord-304556-1f47gvys 228 15 indicate indicate VBP cord-304556-1f47gvys 228 16 that that IN cord-304556-1f47gvys 228 17 efferocytosis efferocytosis NN cord-304556-1f47gvys 228 18 plays play VBZ cord-304556-1f47gvys 228 19 a a DT cord-304556-1f47gvys 228 20 dual dual JJ cord-304556-1f47gvys 228 21 role role NN cord-304556-1f47gvys 228 22 in in IN cord-304556-1f47gvys 228 23 lung lung NN cord-304556-1f47gvys 228 24 infections infection NNS cord-304556-1f47gvys 228 25 : : : cord-304556-1f47gvys 228 26 while while IN cord-304556-1f47gvys 228 27 efficient efficient JJ cord-304556-1f47gvys 228 28 apoptotic apoptotic JJ cord-304556-1f47gvys 228 29 cell cell NN cord-304556-1f47gvys 228 30 uptake uptake NN cord-304556-1f47gvys 228 31 is be VBZ cord-304556-1f47gvys 228 32 required require VBN cord-304556-1f47gvys 228 33 for for IN cord-304556-1f47gvys 228 34 resolution resolution NN cord-304556-1f47gvys 228 35 of of IN cord-304556-1f47gvys 228 36 the the DT cord-304556-1f47gvys 228 37 inflammatory inflammatory JJ cord-304556-1f47gvys 228 38 response response NN cord-304556-1f47gvys 228 39 and and CC cord-304556-1f47gvys 228 40 elimination elimination NN cord-304556-1f47gvys 228 41 of of IN cord-304556-1f47gvys 228 42 certain certain JJ cord-304556-1f47gvys 228 43 intracellular intracellular JJ cord-304556-1f47gvys 228 44 pathogens pathogen NNS cord-304556-1f47gvys 228 45 , , , cord-304556-1f47gvys 228 46 the the DT cord-304556-1f47gvys 228 47 antiinflammatory antiinflammatory JJ cord-304556-1f47gvys 228 48 programmes programme NNS cord-304556-1f47gvys 228 49 activated activate VBN cord-304556-1f47gvys 228 50 upon upon IN cord-304556-1f47gvys 228 51 prolonged prolong VBN cord-304556-1f47gvys 228 52 exposure exposure NN cord-304556-1f47gvys 228 53 to to IN cord-304556-1f47gvys 228 54 apoptotic apoptotic JJ cord-304556-1f47gvys 228 55 cells cell NNS cord-304556-1f47gvys 228 56 might may MD cord-304556-1f47gvys 228 57 increase increase VB cord-304556-1f47gvys 228 58 susceptibility susceptibility NN cord-304556-1f47gvys 228 59 to to IN cord-304556-1f47gvys 228 60 secondary secondary JJ cord-304556-1f47gvys 228 61 infections infection NNS cord-304556-1f47gvys 228 62 and and CC cord-304556-1f47gvys 228 63 infection infection NN cord-304556-1f47gvys 228 64 - - HYPH cord-304556-1f47gvys 228 65 related relate VBN cord-304556-1f47gvys 228 66 exacerbations exacerbation NNS cord-304556-1f47gvys 228 67 of of IN cord-304556-1f47gvys 228 68 chronic chronic JJ cord-304556-1f47gvys 228 69 inflammatory inflammatory JJ cord-304556-1f47gvys 228 70 lung lung NN cord-304556-1f47gvys 228 71 diseases disease NNS cord-304556-1f47gvys 228 72 . . . cord-304556-1f47gvys 229 1 In in IN cord-304556-1f47gvys 229 2 light light NN cord-304556-1f47gvys 229 3 of of IN cord-304556-1f47gvys 229 4 the the DT cord-304556-1f47gvys 229 5 importance importance NN cord-304556-1f47gvys 229 6 of of IN cord-304556-1f47gvys 229 7 effercotysis effercotysis NN cord-304556-1f47gvys 229 8 in in IN cord-304556-1f47gvys 229 9 resolution resolution NN cord-304556-1f47gvys 229 10 of of IN cord-304556-1f47gvys 229 11 inflammation inflammation NN cord-304556-1f47gvys 229 12 and and CC cord-304556-1f47gvys 229 13 the the DT cord-304556-1f47gvys 229 14 reported report VBN cord-304556-1f47gvys 229 15 defects defect NNS cord-304556-1f47gvys 229 16 in in IN cord-304556-1f47gvys 229 17 apoptotic apoptotic JJ cord-304556-1f47gvys 229 18 cell cell NN cord-304556-1f47gvys 229 19 removal removal NN cord-304556-1f47gvys 229 20 in in IN cord-304556-1f47gvys 229 21 chronic chronic JJ cord-304556-1f47gvys 229 22 inflammatory inflammatory JJ cord-304556-1f47gvys 229 23 lung lung NN cord-304556-1f47gvys 229 24 diseases disease NNS cord-304556-1f47gvys 229 25 , , , cord-304556-1f47gvys 229 26 it -PRON- PRP cord-304556-1f47gvys 229 27 is be VBZ cord-304556-1f47gvys 229 28 not not RB cord-304556-1f47gvys 229 29 surprising surprising JJ cord-304556-1f47gvys 229 30 that that IN cord-304556-1f47gvys 229 31 evaluation evaluation NN cord-304556-1f47gvys 229 32 of of IN cord-304556-1f47gvys 229 33 potential potential JJ cord-304556-1f47gvys 229 34 therapeutic therapeutic JJ cord-304556-1f47gvys 229 35 strategies strategy NNS cord-304556-1f47gvys 229 36 aimed aim VBN cord-304556-1f47gvys 229 37 at at IN cord-304556-1f47gvys 229 38 enhancing enhance VBG cord-304556-1f47gvys 229 39 apoptotic apoptotic JJ cord-304556-1f47gvys 229 40 cell cell NN cord-304556-1f47gvys 229 41 uptake uptake NN cord-304556-1f47gvys 229 42 gained gain VBD cord-304556-1f47gvys 229 43 a a DT cord-304556-1f47gvys 229 44 lot lot NN cord-304556-1f47gvys 229 45 of of IN cord-304556-1f47gvys 229 46 attention attention NN cord-304556-1f47gvys 229 47 in in IN cord-304556-1f47gvys 229 48 recent recent JJ cord-304556-1f47gvys 229 49 years year NNS cord-304556-1f47gvys 229 50 [ [ -LRB- cord-304556-1f47gvys 229 51 72 72 CD cord-304556-1f47gvys 229 52 , , , cord-304556-1f47gvys 229 53 73 73 CD cord-304556-1f47gvys 229 54 ] ] -RRB- cord-304556-1f47gvys 229 55 . . . cord-304556-1f47gvys 230 1 Strikingly strikingly RB cord-304556-1f47gvys 230 2 , , , cord-304556-1f47gvys 230 3 glucocorticoids glucocorticoid NNS cord-304556-1f47gvys 230 4 , , , cord-304556-1f47gvys 230 5 which which WDT cord-304556-1f47gvys 230 6 are be VBP cord-304556-1f47gvys 230 7 the the DT cord-304556-1f47gvys 230 8 most most RBS cord-304556-1f47gvys 230 9 commonly commonly RB cord-304556-1f47gvys 230 10 used use VBN cord-304556-1f47gvys 230 11 class class NN cord-304556-1f47gvys 230 12 of of IN cord-304556-1f47gvys 230 13 drugs drug NNS cord-304556-1f47gvys 230 14 in in IN cord-304556-1f47gvys 230 15 the the DT cord-304556-1f47gvys 230 16 treatment treatment NN cord-304556-1f47gvys 230 17 of of IN cord-304556-1f47gvys 230 18 asthma asthma NN cord-304556-1f47gvys 230 19 and and CC cord-304556-1f47gvys 230 20 COPD COPD NNP cord-304556-1f47gvys 230 21 , , , cord-304556-1f47gvys 230 22 increase increase VB cord-304556-1f47gvys 230 23 apoptotic apoptotic JJ cord-304556-1f47gvys 230 24 cell cell NN cord-304556-1f47gvys 230 25 engulfment engulfment NN cord-304556-1f47gvys 230 26 by by IN cord-304556-1f47gvys 230 27 macrophages macrophage NNS cord-304556-1f47gvys 230 28 in in IN cord-304556-1f47gvys 230 29 vitro vitro FW cord-304556-1f47gvys 230 30 [ [ -LRB- cord-304556-1f47gvys 230 31 127 127 CD cord-304556-1f47gvys 230 32 ] ] -RRB- cord-304556-1f47gvys 230 33 and and CC cord-304556-1f47gvys 230 34 restore restore VB cord-304556-1f47gvys 230 35 the the DT cord-304556-1f47gvys 230 36 efferocytic efferocytic JJ cord-304556-1f47gvys 230 37 function function NN cord-304556-1f47gvys 230 38 of of IN cord-304556-1f47gvys 230 39 airway airway NN cord-304556-1f47gvys 230 40 macrophages macrophage NNS cord-304556-1f47gvys 230 41 from from IN cord-304556-1f47gvys 230 42 patients patient NNS cord-304556-1f47gvys 230 43 with with IN cord-304556-1f47gvys 230 44 severe severe JJ cord-304556-1f47gvys 230 45 asthma asthma NN cord-304556-1f47gvys 230 46 [ [ -LRB- cord-304556-1f47gvys 230 47 97 97 CD cord-304556-1f47gvys 230 48 ] ] -RRB- cord-304556-1f47gvys 230 49 . . . cord-304556-1f47gvys 231 1 Upregulation Upregulation NNP cord-304556-1f47gvys 231 2 of of IN cord-304556-1f47gvys 231 3 the the DT cord-304556-1f47gvys 231 4 TAM TAM NNP cord-304556-1f47gvys 231 5 receptor receptor NN cord-304556-1f47gvys 231 6 MerTK mertk NN cord-304556-1f47gvys 231 7 [ [ -LRB- cord-304556-1f47gvys 231 8 128 128 CD cord-304556-1f47gvys 231 9 , , , cord-304556-1f47gvys 231 10 129 129 CD cord-304556-1f47gvys 231 11 ] ] -RRB- cord-304556-1f47gvys 231 12 and and CC cord-304556-1f47gvys 231 13 downregulation downregulation NN cord-304556-1f47gvys 231 14 of of IN cord-304556-1f47gvys 231 15 SIRPα SIRPα NNS cord-304556-1f47gvys 231 16 [ [ -LRB- cord-304556-1f47gvys 231 17 130 130 CD cord-304556-1f47gvys 231 18 ] ] -RRB- cord-304556-1f47gvys 231 19 might may MD cord-304556-1f47gvys 231 20 be be VB cord-304556-1f47gvys 231 21 responsible responsible JJ cord-304556-1f47gvys 231 22 for for IN cord-304556-1f47gvys 231 23 the the DT cord-304556-1f47gvys 231 24 pro pro JJ cord-304556-1f47gvys 231 25 - - JJ cord-304556-1f47gvys 231 26 efferocytic efferocytic JJ cord-304556-1f47gvys 231 27 activity activity NN cord-304556-1f47gvys 231 28 of of IN cord-304556-1f47gvys 231 29 glucocorticoids glucocorticoid NNS cord-304556-1f47gvys 231 30 in in IN cord-304556-1f47gvys 231 31 macrophages macrophage NNS cord-304556-1f47gvys 231 32 . . . cord-304556-1f47gvys 232 1 However however RB cord-304556-1f47gvys 232 2 , , , cord-304556-1f47gvys 232 3 it -PRON- PRP cord-304556-1f47gvys 232 4 remains remain VBZ cord-304556-1f47gvys 232 5 unknown unknown JJ cord-304556-1f47gvys 232 6 whether whether IN cord-304556-1f47gvys 232 7 promotion promotion NN cord-304556-1f47gvys 232 8 of of IN cord-304556-1f47gvys 232 9 apoptotic apoptotic JJ cord-304556-1f47gvys 232 10 cell cell NN cord-304556-1f47gvys 232 11 clearance clearance NN cord-304556-1f47gvys 232 12 significantly significantly RB cord-304556-1f47gvys 232 13 contributes contribute VBZ cord-304556-1f47gvys 232 14 to to IN cord-304556-1f47gvys 232 15 the the DT cord-304556-1f47gvys 232 16 antiinflammatory antiinflammatory JJ cord-304556-1f47gvys 232 17 effects effect NNS cord-304556-1f47gvys 232 18 of of IN cord-304556-1f47gvys 232 19 glucocorticoids glucocorticoid NNS cord-304556-1f47gvys 232 20 in in IN cord-304556-1f47gvys 232 21 patients patient NNS cord-304556-1f47gvys 232 22 with with IN cord-304556-1f47gvys 232 23 lung lung NN cord-304556-1f47gvys 232 24 diseases disease NNS cord-304556-1f47gvys 232 25 . . . cord-304556-1f47gvys 233 1 More More JJR cord-304556-1f47gvys 233 2 systematic systematic JJ cord-304556-1f47gvys 233 3 analyses analysis NNS cord-304556-1f47gvys 233 4 of of IN cord-304556-1f47gvys 233 5 apoptotic apoptotic JJ cord-304556-1f47gvys 233 6 cell cell NN cord-304556-1f47gvys 233 7 accumulation accumulation NN cord-304556-1f47gvys 233 8 and and CC cord-304556-1f47gvys 233 9 efferocytic efferocytic JJ cord-304556-1f47gvys 233 10 functions function NNS cord-304556-1f47gvys 233 11 of of IN cord-304556-1f47gvys 233 12 airway airway NN cord-304556-1f47gvys 233 13 macrophages macrophage NNS cord-304556-1f47gvys 233 14 before before IN cord-304556-1f47gvys 233 15 and and CC cord-304556-1f47gvys 233 16 after after IN cord-304556-1f47gvys 233 17 glucocorticoid glucocorticoid NN cord-304556-1f47gvys 233 18 therapy therapy NN cord-304556-1f47gvys 233 19 in in IN cord-304556-1f47gvys 233 20 responders responder NNS cord-304556-1f47gvys 233 21 and and CC cord-304556-1f47gvys 233 22 nonresponders nonresponder NNS cord-304556-1f47gvys 233 23 are be VBP cord-304556-1f47gvys 233 24 therefore therefore RB cord-304556-1f47gvys 233 25 necessary necessary JJ cord-304556-1f47gvys 233 26 to to TO cord-304556-1f47gvys 233 27 address address VB cord-304556-1f47gvys 233 28 this this DT cord-304556-1f47gvys 233 29 question question NN cord-304556-1f47gvys 233 30 . . . cord-304556-1f47gvys 234 1 Some some DT cord-304556-1f47gvys 234 2 classes class NNS cord-304556-1f47gvys 234 3 of of IN cord-304556-1f47gvys 234 4 medications medication NNS cord-304556-1f47gvys 234 5 widely widely RB cord-304556-1f47gvys 234 6 used use VBN cord-304556-1f47gvys 234 7 in in IN cord-304556-1f47gvys 234 8 the the DT cord-304556-1f47gvys 234 9 clinic clinic NN cord-304556-1f47gvys 234 10 for for IN cord-304556-1f47gvys 234 11 other other JJ cord-304556-1f47gvys 234 12 indications indication NNS cord-304556-1f47gvys 234 13 also also RB cord-304556-1f47gvys 234 14 promote promote VBP cord-304556-1f47gvys 234 15 efferocytosis efferocytosis NN cord-304556-1f47gvys 234 16 . . . cord-304556-1f47gvys 235 1 The the DT cord-304556-1f47gvys 235 2 antibiotic antibiotic JJ cord-304556-1f47gvys 235 3 azithromycin azithromycin NN cord-304556-1f47gvys 235 4 increases increase VBZ cord-304556-1f47gvys 235 5 phagocytosis phagocytosis NN cord-304556-1f47gvys 235 6 of of IN cord-304556-1f47gvys 235 7 apoptotic apoptotic JJ cord-304556-1f47gvys 235 8 cells cell NNS cord-304556-1f47gvys 235 9 by by IN cord-304556-1f47gvys 235 10 human human JJ cord-304556-1f47gvys 235 11 airway airway NN cord-304556-1f47gvys 235 12 macrophages macrophage NNS cord-304556-1f47gvys 235 13 in in IN cord-304556-1f47gvys 235 14 vitro vitro FW cord-304556-1f47gvys 235 15 [ [ -LRB- cord-304556-1f47gvys 235 16 21 21 CD cord-304556-1f47gvys 235 17 , , , cord-304556-1f47gvys 235 18 131 131 CD cord-304556-1f47gvys 235 19 ] ] -RRB- cord-304556-1f47gvys 235 20 , , , cord-304556-1f47gvys 235 21 and and CC cord-304556-1f47gvys 235 22 significant significant JJ cord-304556-1f47gvys 235 23 improvement improvement NN cord-304556-1f47gvys 235 24 of of IN cord-304556-1f47gvys 235 25 the the DT cord-304556-1f47gvys 235 26 efferocytic efferocytic JJ cord-304556-1f47gvys 235 27 function function NN cord-304556-1f47gvys 235 28 of of IN cord-304556-1f47gvys 235 29 airway airway NN cord-304556-1f47gvys 235 30 macrophages macrophage NNS cord-304556-1f47gvys 235 31 from from IN cord-304556-1f47gvys 235 32 COPD COPD NNP cord-304556-1f47gvys 235 33 patients patient NNS cord-304556-1f47gvys 235 34 after after IN cord-304556-1f47gvys 235 35 oral oral JJ cord-304556-1f47gvys 235 36 treatment treatment NN cord-304556-1f47gvys 235 37 with with IN cord-304556-1f47gvys 235 38 azithromycin azithromycin NNP cord-304556-1f47gvys 235 39 has have VBZ cord-304556-1f47gvys 235 40 been be VBN cord-304556-1f47gvys 235 41 reported report VBN cord-304556-1f47gvys 235 42 [ [ -LRB- cord-304556-1f47gvys 235 43 28 28 CD cord-304556-1f47gvys 235 44 ] ] -RRB- cord-304556-1f47gvys 235 45 . . . cord-304556-1f47gvys 236 1 In in IN cord-304556-1f47gvys 236 2 light light NN cord-304556-1f47gvys 236 3 of of IN cord-304556-1f47gvys 236 4 recent recent JJ cord-304556-1f47gvys 236 5 evidence evidence NN cord-304556-1f47gvys 236 6 that that IN cord-304556-1f47gvys 236 7 azithromycin azithromycin NNP cord-304556-1f47gvys 236 8 reduces reduce VBZ cord-304556-1f47gvys 236 9 the the DT cord-304556-1f47gvys 236 10 frequency frequency NN cord-304556-1f47gvys 236 11 of of IN cord-304556-1f47gvys 236 12 exacerbations exacerbation NNS cord-304556-1f47gvys 236 13 in in IN cord-304556-1f47gvys 236 14 COPD COPD NNP cord-304556-1f47gvys 236 15 patients patient NNS cord-304556-1f47gvys 236 16 [ [ -LRB- cord-304556-1f47gvys 236 17 132 132 CD cord-304556-1f47gvys 236 18 ] ] -RRB- cord-304556-1f47gvys 236 19 , , , cord-304556-1f47gvys 236 20 it -PRON- PRP cord-304556-1f47gvys 236 21 is be VBZ cord-304556-1f47gvys 236 22 tempting tempt VBG cord-304556-1f47gvys 236 23 to to TO cord-304556-1f47gvys 236 24 speculate speculate VB cord-304556-1f47gvys 236 25 that that IN cord-304556-1f47gvys 236 26 at at IN cord-304556-1f47gvys 236 27 least least JJS cord-304556-1f47gvys 236 28 part part NN cord-304556-1f47gvys 236 29 of of IN cord-304556-1f47gvys 236 30 the the DT cord-304556-1f47gvys 236 31 immunomodulatory immunomodulatory JJ cord-304556-1f47gvys 236 32 activities activity NNS cord-304556-1f47gvys 236 33 of of IN cord-304556-1f47gvys 236 34 macrolide macrolide JJ cord-304556-1f47gvys 236 35 antibiotics antibiotic NNS cord-304556-1f47gvys 236 36 can can MD cord-304556-1f47gvys 236 37 be be VB cord-304556-1f47gvys 236 38 attributed attribute VBN cord-304556-1f47gvys 236 39 to to IN cord-304556-1f47gvys 236 40 their -PRON- PRP$ cord-304556-1f47gvys 236 41 effects effect NNS cord-304556-1f47gvys 236 42 on on IN cord-304556-1f47gvys 236 43 apoptotic apoptotic JJ cord-304556-1f47gvys 236 44 cell cell NN cord-304556-1f47gvys 236 45 clearance clearance NN cord-304556-1f47gvys 236 46 . . . cord-304556-1f47gvys 237 1 Similarly similarly RB cord-304556-1f47gvys 237 2 , , , cord-304556-1f47gvys 237 3 PPARγ PPARγ NNS cord-304556-1f47gvys 237 4 agonists agonist NNS cord-304556-1f47gvys 237 5 , , , cord-304556-1f47gvys 237 6 which which WDT cord-304556-1f47gvys 237 7 are be VBP cord-304556-1f47gvys 237 8 used use VBN cord-304556-1f47gvys 237 9 as as IN cord-304556-1f47gvys 237 10 insulin insulin NN cord-304556-1f47gvys 237 11 sensitizers sensitizer NNS cord-304556-1f47gvys 237 12 in in IN cord-304556-1f47gvys 237 13 diabetes diabetes NN cord-304556-1f47gvys 237 14 mellitus mellitus NN cord-304556-1f47gvys 237 15 , , , cord-304556-1f47gvys 237 16 but but CC cord-304556-1f47gvys 237 17 also also RB cord-304556-1f47gvys 237 18 display display VB cord-304556-1f47gvys 237 19 broad broad JJ cord-304556-1f47gvys 237 20 antiinflammatory antiinflammatory JJ cord-304556-1f47gvys 237 21 effects effect NNS cord-304556-1f47gvys 237 22 , , , cord-304556-1f47gvys 237 23 promote promote VB cord-304556-1f47gvys 237 24 efferocytosis efferocytosis NN cord-304556-1f47gvys 237 25 by by IN cord-304556-1f47gvys 237 26 airway airway NN cord-304556-1f47gvys 237 27 macrophages macrophage NNS cord-304556-1f47gvys 237 28 in in IN cord-304556-1f47gvys 237 29 vitro vitro FW cord-304556-1f47gvys 237 30 and and CC cord-304556-1f47gvys 237 31 ameliorate ameliorate VB cord-304556-1f47gvys 237 32 disease disease NN cord-304556-1f47gvys 237 33 symptoms symptom NNS cord-304556-1f47gvys 237 34 in in IN cord-304556-1f47gvys 237 35 animal animal NN cord-304556-1f47gvys 237 36 models model NNS cord-304556-1f47gvys 237 37 of of IN cord-304556-1f47gvys 237 38 pulmonary pulmonary JJ cord-304556-1f47gvys 237 39 inflammation inflammation NN cord-304556-1f47gvys 237 40 [ [ -LRB- cord-304556-1f47gvys 237 41 133 133 CD cord-304556-1f47gvys 237 42 , , , cord-304556-1f47gvys 237 43 134 134 CD cord-304556-1f47gvys 237 44 ] ] -RRB- cord-304556-1f47gvys 237 45 . . . cord-304556-1f47gvys 238 1 Enhancement enhancement NN cord-304556-1f47gvys 238 2 of of IN cord-304556-1f47gvys 238 3 apoptotic apoptotic JJ cord-304556-1f47gvys 238 4 cell cell NN cord-304556-1f47gvys 238 5 engulfment engulfment NN cord-304556-1f47gvys 238 6 is be VBZ cord-304556-1f47gvys 238 7 also also RB cord-304556-1f47gvys 238 8 observed observe VBN cord-304556-1f47gvys 238 9 after after IN cord-304556-1f47gvys 238 10 treatment treatment NN cord-304556-1f47gvys 238 11 of of IN cord-304556-1f47gvys 238 12 macrophages macrophage NNS cord-304556-1f47gvys 238 13 from from IN cord-304556-1f47gvys 238 14 COPD COPD NNP cord-304556-1f47gvys 238 15 patients patient NNS cord-304556-1f47gvys 238 16 with with IN cord-304556-1f47gvys 238 17 simvastatin simvastatin NN cord-304556-1f47gvys 238 18 [ [ -LRB- cord-304556-1f47gvys 238 19 135 135 CD cord-304556-1f47gvys 238 20 ] ] -RRB- cord-304556-1f47gvys 238 21 , , , cord-304556-1f47gvys 238 22 a a DT cord-304556-1f47gvys 238 23 member member NN cord-304556-1f47gvys 238 24 of of IN cord-304556-1f47gvys 238 25 the the DT cord-304556-1f47gvys 238 26 statin statin NN cord-304556-1f47gvys 238 27 family family NN cord-304556-1f47gvys 238 28 of of IN cord-304556-1f47gvys 238 29 cholesterol cholesterol NN cord-304556-1f47gvys 238 30 - - HYPH cord-304556-1f47gvys 238 31 lowering lower VBG cord-304556-1f47gvys 238 32 drugs drug NNS cord-304556-1f47gvys 238 33 , , , cord-304556-1f47gvys 238 34 and and CC cord-304556-1f47gvys 238 35 retrospective retrospective JJ cord-304556-1f47gvys 238 36 studies study NNS cord-304556-1f47gvys 238 37 suggested suggest VBD cord-304556-1f47gvys 238 38 that that IN cord-304556-1f47gvys 238 39 statins statin NNS cord-304556-1f47gvys 238 40 might may MD cord-304556-1f47gvys 238 41 reduce reduce VB cord-304556-1f47gvys 238 42 the the DT cord-304556-1f47gvys 238 43 risk risk NN cord-304556-1f47gvys 238 44 of of IN cord-304556-1f47gvys 238 45 COPD COPD NNP cord-304556-1f47gvys 238 46 exacerbations exacerbation NNS cord-304556-1f47gvys 238 47 and and CC cord-304556-1f47gvys 238 48 mortality mortality NN cord-304556-1f47gvys 238 49 [ [ -LRB- cord-304556-1f47gvys 238 50 136 136 CD cord-304556-1f47gvys 238 51 , , , cord-304556-1f47gvys 238 52 137 137 CD cord-304556-1f47gvys 238 53 ] ] -RRB- cord-304556-1f47gvys 238 54 . . . cord-304556-1f47gvys 239 1 More more RBR cord-304556-1f47gvys 239 2 recently recently RB cord-304556-1f47gvys 239 3 however however RB cord-304556-1f47gvys 239 4 , , , cord-304556-1f47gvys 239 5 in in IN cord-304556-1f47gvys 239 6 a a DT cord-304556-1f47gvys 239 7 large large JJ cord-304556-1f47gvys 239 8 randomised randomised JJ cord-304556-1f47gvys 239 9 clinical clinical JJ cord-304556-1f47gvys 239 10 trial trial NN cord-304556-1f47gvys 239 11 , , , cord-304556-1f47gvys 239 12 simvastatin simvastatin NN cord-304556-1f47gvys 239 13 treatment treatment NN cord-304556-1f47gvys 239 14 had have VBD cord-304556-1f47gvys 239 15 no no DT cord-304556-1f47gvys 239 16 effect effect NN cord-304556-1f47gvys 239 17 on on IN cord-304556-1f47gvys 239 18 exacerbation exacerbation NN cord-304556-1f47gvys 239 19 rates rate NNS cord-304556-1f47gvys 239 20 in in IN cord-304556-1f47gvys 239 21 COPD COPD NNP cord-304556-1f47gvys 239 22 patients patient NNS cord-304556-1f47gvys 239 23 [ [ -LRB- cord-304556-1f47gvys 239 24 138 138 CD cord-304556-1f47gvys 239 25 ] ] -RRB- cord-304556-1f47gvys 239 26 , , , cord-304556-1f47gvys 239 27 though though IN cord-304556-1f47gvys 239 28 the the DT cord-304556-1f47gvys 239 29 efferocytic efferocytic JJ cord-304556-1f47gvys 239 30 function function NN cord-304556-1f47gvys 239 31 of of IN cord-304556-1f47gvys 239 32 airway airway NN cord-304556-1f47gvys 239 33 macrophages macrophage NNS cord-304556-1f47gvys 239 34 was be VBD cord-304556-1f47gvys 239 35 not not RB cord-304556-1f47gvys 239 36 analysed analyse VBN cord-304556-1f47gvys 239 37 in in IN cord-304556-1f47gvys 239 38 this this DT cord-304556-1f47gvys 239 39 study study NN cord-304556-1f47gvys 239 40 . . . cord-304556-1f47gvys 240 1 It -PRON- PRP cord-304556-1f47gvys 240 2 remains remain VBZ cord-304556-1f47gvys 240 3 an an DT cord-304556-1f47gvys 240 4 open open JJ cord-304556-1f47gvys 240 5 question question NN cord-304556-1f47gvys 240 6 if if IN cord-304556-1f47gvys 240 7 patients patient NNS cord-304556-1f47gvys 240 8 with with IN cord-304556-1f47gvys 240 9 COPD COPD NNP cord-304556-1f47gvys 240 10 can can MD cord-304556-1f47gvys 240 11 be be VB cord-304556-1f47gvys 240 12 stratified stratified JJ cord-304556-1f47gvys 240 13 to to TO cord-304556-1f47gvys 240 14 identify identify VB cord-304556-1f47gvys 240 15 a a DT cord-304556-1f47gvys 240 16 subgroup subgroup NN cord-304556-1f47gvys 240 17 of of IN cord-304556-1f47gvys 240 18 patients patient NNS cord-304556-1f47gvys 240 19 that that WDT cord-304556-1f47gvys 240 20 responds respond VBZ cord-304556-1f47gvys 240 21 to to TO cord-304556-1f47gvys 240 22 statin statin VB cord-304556-1f47gvys 240 23 treatment treatment NN cord-304556-1f47gvys 240 24 and and CC cord-304556-1f47gvys 240 25 whether whether IN cord-304556-1f47gvys 240 26 this this DT cord-304556-1f47gvys 240 27 is be VBZ cord-304556-1f47gvys 240 28 related relate VBN cord-304556-1f47gvys 240 29 to to IN cord-304556-1f47gvys 240 30 effects effect NNS cord-304556-1f47gvys 240 31 on on IN cord-304556-1f47gvys 240 32 apoptotic apoptotic JJ cord-304556-1f47gvys 240 33 cell cell NN cord-304556-1f47gvys 240 34 clearance clearance NN cord-304556-1f47gvys 240 35 . . . cord-304556-1f47gvys 241 1 Finally finally RB cord-304556-1f47gvys 241 2 , , , cord-304556-1f47gvys 241 3 the the DT cord-304556-1f47gvys 241 4 observations observation NNS cord-304556-1f47gvys 241 5 that that WDT cord-304556-1f47gvys 241 6 aberrant aberrant JJ cord-304556-1f47gvys 241 7 expression expression NN cord-304556-1f47gvys 241 8 and and CC cord-304556-1f47gvys 241 9 activity activity NN cord-304556-1f47gvys 241 10 of of IN cord-304556-1f47gvys 241 11 the the DT cord-304556-1f47gvys 241 12 TAM TAM NNP cord-304556-1f47gvys 241 13 receptor receptor NN cord-304556-1f47gvys 241 14 Axl Axl NNP cord-304556-1f47gvys 241 15 has have VBZ cord-304556-1f47gvys 241 16 an an DT cord-304556-1f47gvys 241 17 oncogenic oncogenic JJ cord-304556-1f47gvys 241 18 function function NN cord-304556-1f47gvys 241 19 in in IN cord-304556-1f47gvys 241 20 haematological haematological NN cord-304556-1f47gvys 241 21 and and CC cord-304556-1f47gvys 241 22 epithelial epithelial JJ cord-304556-1f47gvys 241 23 malignancies malignancy NNS cord-304556-1f47gvys 241 24 triggered trigger VBD cord-304556-1f47gvys 241 25 the the DT cord-304556-1f47gvys 241 26 interest interest NN cord-304556-1f47gvys 241 27 in in IN cord-304556-1f47gvys 241 28 targeting target VBG cord-304556-1f47gvys 241 29 the the DT cord-304556-1f47gvys 241 30 activity activity NN cord-304556-1f47gvys 241 31 of of IN cord-304556-1f47gvys 241 32 PtdSer ptdser JJ cord-304556-1f47gvys 241 33 recognition recognition NN cord-304556-1f47gvys 241 34 receptors receptor NNS cord-304556-1f47gvys 241 35 , , , cord-304556-1f47gvys 241 36 and and CC cord-304556-1f47gvys 241 37 a a DT cord-304556-1f47gvys 241 38 small small JJ cord-304556-1f47gvys 241 39 molecule molecule NN cord-304556-1f47gvys 241 40 inhibitor inhibitor NN cord-304556-1f47gvys 241 41 of of IN cord-304556-1f47gvys 241 42 Axl Axl NNP cord-304556-1f47gvys 241 43 is be VBZ cord-304556-1f47gvys 241 44 currently currently RB cord-304556-1f47gvys 241 45 in in IN cord-304556-1f47gvys 241 46 phase phase NN cord-304556-1f47gvys 242 1 I -PRON- PRP cord-304556-1f47gvys 242 2 clinical clinical JJ cord-304556-1f47gvys 242 3 trials trial NNS cord-304556-1f47gvys 242 4 [ [ -LRB- cord-304556-1f47gvys 242 5 139 139 CD cord-304556-1f47gvys 242 6 ] ] -RRB- cord-304556-1f47gvys 242 7 . . . cord-304556-1f47gvys 243 1 However however RB cord-304556-1f47gvys 243 2 , , , cord-304556-1f47gvys 243 3 preclinical preclinical JJ cord-304556-1f47gvys 243 4 studies study NNS cord-304556-1f47gvys 243 5 indicate indicate VBP cord-304556-1f47gvys 243 6 that that IN cord-304556-1f47gvys 243 7 pharmacological pharmacological JJ cord-304556-1f47gvys 243 8 modulators modulator NNS cord-304556-1f47gvys 243 9 of of IN cord-304556-1f47gvys 243 10 PtdSer ptdser JJ cord-304556-1f47gvys 243 11 recognition recognition NN cord-304556-1f47gvys 243 12 receptors receptor NNS cord-304556-1f47gvys 243 13 might may MD cord-304556-1f47gvys 243 14 have have VB cord-304556-1f47gvys 243 15 a a DT cord-304556-1f47gvys 243 16 significant significant JJ cord-304556-1f47gvys 243 17 impact impact NN cord-304556-1f47gvys 243 18 on on IN cord-304556-1f47gvys 243 19 the the DT cord-304556-1f47gvys 243 20 immune immune JJ cord-304556-1f47gvys 243 21 system system NN cord-304556-1f47gvys 243 22 , , , cord-304556-1f47gvys 243 23 especially especially RB cord-304556-1f47gvys 243 24 in in IN cord-304556-1f47gvys 243 25 the the DT cord-304556-1f47gvys 243 26 context context NN cord-304556-1f47gvys 243 27 of of IN cord-304556-1f47gvys 243 28 lung lung NN cord-304556-1f47gvys 243 29 immunopathology immunopathology NN cord-304556-1f47gvys 243 30 . . . cord-304556-1f47gvys 244 1 In in IN cord-304556-1f47gvys 244 2 light light NN cord-304556-1f47gvys 244 3 of of IN cord-304556-1f47gvys 244 4 the the DT cord-304556-1f47gvys 244 5 critical critical JJ cord-304556-1f47gvys 244 6 role role NN cord-304556-1f47gvys 244 7 of of IN cord-304556-1f47gvys 244 8 Axl Axl NNP cord-304556-1f47gvys 244 9 in in IN cord-304556-1f47gvys 244 10 resolution resolution NN cord-304556-1f47gvys 244 11 of of IN cord-304556-1f47gvys 244 12 lung lung NN cord-304556-1f47gvys 244 13 inflammation inflammation NN cord-304556-1f47gvys 244 14 upon upon IN cord-304556-1f47gvys 244 15 influenza influenza NN cord-304556-1f47gvys 244 16 infection infection NN cord-304556-1f47gvys 244 17 [ [ -LRB- cord-304556-1f47gvys 244 18 2 2 CD cord-304556-1f47gvys 244 19 ] ] -RRB- cord-304556-1f47gvys 244 20 , , , cord-304556-1f47gvys 244 21 any any DT cord-304556-1f47gvys 244 22 attempts attempt NNS cord-304556-1f47gvys 244 23 to to TO cord-304556-1f47gvys 244 24 target target VB cord-304556-1f47gvys 244 25 Axl Axl NNP cord-304556-1f47gvys 244 26 activity activity NN cord-304556-1f47gvys 244 27 systemically systemically RB cord-304556-1f47gvys 244 28 should should MD cord-304556-1f47gvys 244 29 proceed proceed VB cord-304556-1f47gvys 244 30 with with IN cord-304556-1f47gvys 244 31 caution caution NN cord-304556-1f47gvys 244 32 due due IN cord-304556-1f47gvys 244 33 to to IN cord-304556-1f47gvys 244 34 potential potential JJ cord-304556-1f47gvys 244 35 adverse adverse JJ cord-304556-1f47gvys 244 36 events event NNS cord-304556-1f47gvys 244 37 related relate VBN cord-304556-1f47gvys 244 38 to to IN cord-304556-1f47gvys 244 39 exaggerated exaggerated JJ cord-304556-1f47gvys 244 40 inflammatory inflammatory JJ cord-304556-1f47gvys 244 41 responses response NNS cord-304556-1f47gvys 244 42 to to IN cord-304556-1f47gvys 244 43 respiratory respiratory JJ cord-304556-1f47gvys 244 44 infections infection NNS cord-304556-1f47gvys 244 45 . . . cord-304556-1f47gvys 245 1 Similar similar JJ cord-304556-1f47gvys 245 2 to to IN cord-304556-1f47gvys 245 3 Axl Axl NNP cord-304556-1f47gvys 245 4 , , , cord-304556-1f47gvys 245 5 MerTK mertk NN cord-304556-1f47gvys 245 6 signalling signalling NN cord-304556-1f47gvys 245 7 is be VBZ cord-304556-1f47gvys 245 8 also also RB cord-304556-1f47gvys 245 9 required require VBN cord-304556-1f47gvys 245 10 for for IN cord-304556-1f47gvys 245 11 silencing silencing NN cord-304556-1f47gvys 245 12 of of IN cord-304556-1f47gvys 245 13 lung lung NN cord-304556-1f47gvys 245 14 inflammation inflammation NN cord-304556-1f47gvys 245 15 : : : cord-304556-1f47gvys 245 16 inhibition inhibition NN cord-304556-1f47gvys 245 17 of of IN cord-304556-1f47gvys 245 18 MerTK mertk NN cord-304556-1f47gvys 245 19 proteolytic proteolytic JJ cord-304556-1f47gvys 245 20 cleavage cleavage NN cord-304556-1f47gvys 245 21 by by IN cord-304556-1f47gvys 245 22 the the DT cord-304556-1f47gvys 245 23 ADAM17 adam17 CD cord-304556-1f47gvys 245 24 inhibitor inhibitor NN cord-304556-1f47gvys 245 25 TAPI-0 TAPI-0 NNP cord-304556-1f47gvys 245 26 restores restore VBZ cord-304556-1f47gvys 245 27 MerTK mertk NN cord-304556-1f47gvys 245 28 expression expression NN cord-304556-1f47gvys 245 29 and and CC cord-304556-1f47gvys 245 30 attenuates attenuate VBZ cord-304556-1f47gvys 245 31 inflammation inflammation NN cord-304556-1f47gvys 245 32 during during IN cord-304556-1f47gvys 245 33 LPS LPS NNP cord-304556-1f47gvys 245 34 - - HYPH cord-304556-1f47gvys 245 35 induced induce VBN cord-304556-1f47gvys 245 36 lung lung NN cord-304556-1f47gvys 245 37 injury injury NN cord-304556-1f47gvys 245 38 [ [ -LRB- cord-304556-1f47gvys 245 39 140 140 CD cord-304556-1f47gvys 245 40 ] ] -RRB- cord-304556-1f47gvys 245 41 , , , cord-304556-1f47gvys 245 42 whereas whereas IN cord-304556-1f47gvys 245 43 administration administration NN cord-304556-1f47gvys 245 44 of of IN cord-304556-1f47gvys 245 45 a a DT cord-304556-1f47gvys 245 46 MerTK mertk NN cord-304556-1f47gvys 245 47 blocking block VBG cord-304556-1f47gvys 245 48 antibody antibody NN cord-304556-1f47gvys 245 49 has have VBZ cord-304556-1f47gvys 245 50 the the DT cord-304556-1f47gvys 245 51 opposite opposite JJ cord-304556-1f47gvys 245 52 effect effect NN cord-304556-1f47gvys 245 53 [ [ -LRB- cord-304556-1f47gvys 245 54 141 141 CD cord-304556-1f47gvys 245 55 ] ] -RRB- cord-304556-1f47gvys 245 56 . . . cord-304556-1f47gvys 246 1 These these DT cord-304556-1f47gvys 246 2 results result NNS cord-304556-1f47gvys 246 3 suggest suggest VBP cord-304556-1f47gvys 246 4 that that IN cord-304556-1f47gvys 246 5 activating activate VBG cord-304556-1f47gvys 246 6 antibodies antibody NNS cord-304556-1f47gvys 246 7 or or CC cord-304556-1f47gvys 246 8 compounds compound NNS cord-304556-1f47gvys 246 9 which which WDT cord-304556-1f47gvys 246 10 prevent prevent VBP cord-304556-1f47gvys 246 11 shedding shedding NN cord-304556-1f47gvys 246 12 of of IN cord-304556-1f47gvys 246 13 TAM tam NN cord-304556-1f47gvys 246 14 receptors receptor NNS cord-304556-1f47gvys 246 15 could could MD cord-304556-1f47gvys 246 16 be be VB cord-304556-1f47gvys 246 17 beneficial beneficial JJ cord-304556-1f47gvys 246 18 in in IN cord-304556-1f47gvys 246 19 the the DT cord-304556-1f47gvys 246 20 context context JJ cord-304556-1f47gvys 246 21 chronic chronic NN cord-304556-1f47gvys 246 22 lung lung NN cord-304556-1f47gvys 246 23 diseases disease NNS cord-304556-1f47gvys 246 24 . . . cord-304556-1f47gvys 247 1 Indeed indeed RB cord-304556-1f47gvys 247 2 , , , cord-304556-1f47gvys 247 3 TAM TAM NNP cord-304556-1f47gvys 247 4 receptors receptor NNS cord-304556-1f47gvys 247 5 can can MD cord-304556-1f47gvys 247 6 be be VB cord-304556-1f47gvys 247 7 activated activate VBN cord-304556-1f47gvys 247 8 independently independently RB cord-304556-1f47gvys 247 9 of of IN cord-304556-1f47gvys 247 10 apoptotic apoptotic JJ cord-304556-1f47gvys 247 11 cell cell NN cord-304556-1f47gvys 247 12 engulfment engulfment NN cord-304556-1f47gvys 247 13 by by IN cord-304556-1f47gvys 247 14 specific specific JJ cord-304556-1f47gvys 247 15 antibodies antibody NNS cord-304556-1f47gvys 247 16 [ [ -LRB- cord-304556-1f47gvys 247 17 46 46 CD cord-304556-1f47gvys 247 18 , , , cord-304556-1f47gvys 247 19 142 142 CD cord-304556-1f47gvys 247 20 ] ] -RRB- cord-304556-1f47gvys 247 21 , , , cord-304556-1f47gvys 247 22 though though IN cord-304556-1f47gvys 247 23 their -PRON- PRP$ cord-304556-1f47gvys 247 24 effects effect NNS cord-304556-1f47gvys 247 25 have have VBP cord-304556-1f47gvys 247 26 not not RB cord-304556-1f47gvys 247 27 been be VBN cord-304556-1f47gvys 247 28 tested test VBN cord-304556-1f47gvys 247 29 in in IN cord-304556-1f47gvys 247 30 models model NNS cord-304556-1f47gvys 247 31 of of IN cord-304556-1f47gvys 247 32 lung lung NN cord-304556-1f47gvys 247 33 inflammation inflammation NN cord-304556-1f47gvys 247 34 . . . cord-304556-1f47gvys 248 1 In in IN cord-304556-1f47gvys 248 2 that that DT cord-304556-1f47gvys 248 3 regard regard NN cord-304556-1f47gvys 248 4 , , , cord-304556-1f47gvys 248 5 it -PRON- PRP cord-304556-1f47gvys 248 6 is be VBZ cord-304556-1f47gvys 248 7 noteworthy noteworthy JJ cord-304556-1f47gvys 248 8 that that IN cord-304556-1f47gvys 248 9 activation activation NN cord-304556-1f47gvys 248 10 of of IN cord-304556-1f47gvys 248 11 TAM TAM NNP cord-304556-1f47gvys 248 12 receptors receptor NNS cord-304556-1f47gvys 248 13 leads lead VBZ cord-304556-1f47gvys 248 14 to to IN cord-304556-1f47gvys 248 15 shedding shed VBG cord-304556-1f47gvys 248 16 of of IN cord-304556-1f47gvys 248 17 their -PRON- PRP$ cord-304556-1f47gvys 248 18 extracellular extracellular JJ cord-304556-1f47gvys 248 19 domains domain NNS cord-304556-1f47gvys 248 20 and and CC cord-304556-1f47gvys 248 21 soluble soluble JJ cord-304556-1f47gvys 248 22 forms form NNS cord-304556-1f47gvys 248 23 of of IN cord-304556-1f47gvys 248 24 TAM TAM NNP cord-304556-1f47gvys 248 25 receptors receptor NNS cord-304556-1f47gvys 248 26 can can MD cord-304556-1f47gvys 248 27 act act VB cord-304556-1f47gvys 248 28 as as IN cord-304556-1f47gvys 248 29 decoy decoy NN cord-304556-1f47gvys 248 30 receptors receptor NNS cord-304556-1f47gvys 248 31 and and CC cord-304556-1f47gvys 248 32 suppress suppress VB cord-304556-1f47gvys 248 33 apoptotic apoptotic JJ cord-304556-1f47gvys 248 34 cell cell NN cord-304556-1f47gvys 248 35 engulfment engulfment NN cord-304556-1f47gvys 248 36 by by IN cord-304556-1f47gvys 248 37 macrophages macrophage NNS cord-304556-1f47gvys 248 38 [ [ -LRB- cord-304556-1f47gvys 248 39 143 143 CD cord-304556-1f47gvys 248 40 ] ] -RRB- cord-304556-1f47gvys 248 41 . . . cord-304556-1f47gvys 249 1 Although although IN cord-304556-1f47gvys 249 2 alterations alteration NNS cord-304556-1f47gvys 249 3 in in IN cord-304556-1f47gvys 249 4 the the DT cord-304556-1f47gvys 249 5 levels level NNS cord-304556-1f47gvys 249 6 of of IN cord-304556-1f47gvys 249 7 soluble soluble JJ cord-304556-1f47gvys 249 8 TAM TAM NNP cord-304556-1f47gvys 249 9 receptors receptor NNS cord-304556-1f47gvys 249 10 are be VBP cord-304556-1f47gvys 249 11 noted note VBN cord-304556-1f47gvys 249 12 in in IN cord-304556-1f47gvys 249 13 several several JJ cord-304556-1f47gvys 249 14 pathologies pathology NNS cord-304556-1f47gvys 249 15 [ [ -LRB- cord-304556-1f47gvys 249 16 144 144 CD cord-304556-1f47gvys 249 17 , , , cord-304556-1f47gvys 249 18 145 145 CD cord-304556-1f47gvys 249 19 ] ] -RRB- cord-304556-1f47gvys 249 20 , , , cord-304556-1f47gvys 249 21 their -PRON- PRP$ cord-304556-1f47gvys 249 22 physiological physiological JJ cord-304556-1f47gvys 249 23 role role NN cord-304556-1f47gvys 249 24 is be VBZ cord-304556-1f47gvys 249 25 still still RB cord-304556-1f47gvys 249 26 poorly poorly RB cord-304556-1f47gvys 249 27 understood understand VBN cord-304556-1f47gvys 249 28 . . . cord-304556-1f47gvys 250 1 It -PRON- PRP cord-304556-1f47gvys 250 2 remains remain VBZ cord-304556-1f47gvys 250 3 unknown unknown JJ cord-304556-1f47gvys 250 4 if if IN cord-304556-1f47gvys 250 5 administration administration NN cord-304556-1f47gvys 250 6 of of IN cord-304556-1f47gvys 250 7 antibodies antibody NNS cord-304556-1f47gvys 250 8 targeting target VBG cord-304556-1f47gvys 250 9 TAM tam NN cord-304556-1f47gvys 250 10 receptors receptor NNS cord-304556-1f47gvys 250 11 would would MD cord-304556-1f47gvys 250 12 cause cause VB cord-304556-1f47gvys 250 13 their -PRON- PRP$ cord-304556-1f47gvys 250 14 sequestration sequestration NN cord-304556-1f47gvys 250 15 and and CC cord-304556-1f47gvys 250 16 what what WDT cord-304556-1f47gvys 250 17 consequences consequence VBZ cord-304556-1f47gvys 250 18 it -PRON- PRP cord-304556-1f47gvys 250 19 would would MD cord-304556-1f47gvys 250 20 have have VB cord-304556-1f47gvys 250 21 for for IN cord-304556-1f47gvys 250 22 the the DT cord-304556-1f47gvys 250 23 immune immune JJ cord-304556-1f47gvys 250 24 homeostasis homeostasis NN cord-304556-1f47gvys 250 25 of of IN cord-304556-1f47gvys 250 26 the the DT cord-304556-1f47gvys 250 27 lung lung NN cord-304556-1f47gvys 250 28 . . . cord-304556-1f47gvys 251 1 Since since IN cord-304556-1f47gvys 251 2 the the DT cord-304556-1f47gvys 251 3 initial initial JJ cord-304556-1f47gvys 251 4 discovery discovery NN cord-304556-1f47gvys 251 5 of of IN cord-304556-1f47gvys 251 6 defects defect NNS cord-304556-1f47gvys 251 7 in in IN cord-304556-1f47gvys 251 8 apoptotic apoptotic JJ cord-304556-1f47gvys 251 9 cell cell NN cord-304556-1f47gvys 251 10 clearance clearance NN cord-304556-1f47gvys 251 11 in in IN cord-304556-1f47gvys 251 12 asthma asthma NN cord-304556-1f47gvys 251 13 and and CC cord-304556-1f47gvys 251 14 COPD COPD NNP cord-304556-1f47gvys 251 15 , , , cord-304556-1f47gvys 251 16 great great JJ cord-304556-1f47gvys 251 17 progress progress NN cord-304556-1f47gvys 251 18 has have VBZ cord-304556-1f47gvys 251 19 been be VBN cord-304556-1f47gvys 251 20 made make VBN cord-304556-1f47gvys 251 21 in in IN cord-304556-1f47gvys 251 22 our -PRON- PRP$ cord-304556-1f47gvys 251 23 understanding understanding NN cord-304556-1f47gvys 251 24 of of IN cord-304556-1f47gvys 251 25 the the DT cord-304556-1f47gvys 251 26 molecular molecular JJ cord-304556-1f47gvys 251 27 mechanisms mechanism NNS cord-304556-1f47gvys 251 28 of of IN cord-304556-1f47gvys 251 29 efferocytosis efferocytosis NN cord-304556-1f47gvys 251 30 and and CC cord-304556-1f47gvys 251 31 several several JJ cord-304556-1f47gvys 251 32 new new JJ cord-304556-1f47gvys 251 33 processes process NNS cord-304556-1f47gvys 251 34 through through IN cord-304556-1f47gvys 251 35 which which WDT cord-304556-1f47gvys 251 36 efferocytosis efferocytosis NNP cord-304556-1f47gvys 251 37 modulates modulate VBZ cord-304556-1f47gvys 251 38 host host NN cord-304556-1f47gvys 251 39 immune immune JJ cord-304556-1f47gvys 251 40 responses response NNS cord-304556-1f47gvys 251 41 have have VBP cord-304556-1f47gvys 251 42 been be VBN cord-304556-1f47gvys 251 43 characterised characterise VBN cord-304556-1f47gvys 251 44 ( ( -LRB- cord-304556-1f47gvys 251 45 Fig fig NN cord-304556-1f47gvys 251 46 . . . cord-304556-1f47gvys 251 47 1 1 CD cord-304556-1f47gvys 251 48 ) ) -RRB- cord-304556-1f47gvys 251 49 . . . cord-304556-1f47gvys 252 1 Consequently consequently RB cord-304556-1f47gvys 252 2 , , , cord-304556-1f47gvys 252 3 new new JJ cord-304556-1f47gvys 252 4 questions question NNS cord-304556-1f47gvys 252 5 have have VBP cord-304556-1f47gvys 252 6 emerged emerge VBN cord-304556-1f47gvys 252 7 regarding regard VBG cord-304556-1f47gvys 252 8 the the DT cord-304556-1f47gvys 252 9 role role NN cord-304556-1f47gvys 252 10 of of IN cord-304556-1f47gvys 252 11 apoptotic apoptotic JJ cord-304556-1f47gvys 252 12 cell cell NN cord-304556-1f47gvys 252 13 removal removal NN cord-304556-1f47gvys 252 14 in in IN cord-304556-1f47gvys 252 15 lung lung NN cord-304556-1f47gvys 252 16 homeostasis homeostasis NN cord-304556-1f47gvys 252 17 and and CC cord-304556-1f47gvys 252 18 the the DT cord-304556-1f47gvys 252 19 most most RBS cord-304556-1f47gvys 252 20 important important JJ cord-304556-1f47gvys 252 21 of of IN cord-304556-1f47gvys 252 22 them -PRON- PRP cord-304556-1f47gvys 252 23 are be VBP cord-304556-1f47gvys 252 24 listed list VBN cord-304556-1f47gvys 252 25 in in IN cord-304556-1f47gvys 252 26 Box Box NNP cord-304556-1f47gvys 252 27 1 1 CD cord-304556-1f47gvys 252 28 . . . cord-304556-1f47gvys 253 1 Future future JJ cord-304556-1f47gvys 253 2 studies study NNS cord-304556-1f47gvys 253 3 addressing address VBG cord-304556-1f47gvys 253 4 these these DT cord-304556-1f47gvys 253 5 questions question NNS cord-304556-1f47gvys 253 6 , , , cord-304556-1f47gvys 253 7 especially especially RB cord-304556-1f47gvys 253 8 attempts attempt VBZ cord-304556-1f47gvys 253 9 to to TO cord-304556-1f47gvys 253 10 therapeutically therapeutically RB cord-304556-1f47gvys 253 11 manipulate manipulate VB cord-304556-1f47gvys 253 12 efferocytosis efferocytosis NN cord-304556-1f47gvys 253 13 in in IN cord-304556-1f47gvys 253 14 the the DT cord-304556-1f47gvys 253 15 clinic clinic NN cord-304556-1f47gvys 253 16 , , , cord-304556-1f47gvys 253 17 should should MD cord-304556-1f47gvys 253 18 be be VB cord-304556-1f47gvys 253 19 designed design VBN cord-304556-1f47gvys 253 20 in in IN cord-304556-1f47gvys 253 21 the the DT cord-304556-1f47gvys 253 22 context context NN cord-304556-1f47gvys 253 23 of of IN cord-304556-1f47gvys 253 24 the the DT cord-304556-1f47gvys 253 25 multiple multiple JJ cord-304556-1f47gvys 253 26 roles role NNS cord-304556-1f47gvys 253 27 of of IN cord-304556-1f47gvys 253 28 apoptotic apoptotic JJ cord-304556-1f47gvys 253 29 cell cell NN cord-304556-1f47gvys 253 30 phagocytosis phagocytosis NN cord-304556-1f47gvys 253 31 in in IN cord-304556-1f47gvys 253 32 resolution resolution NN cord-304556-1f47gvys 253 33 of of IN cord-304556-1f47gvys 253 34 inflammation inflammation NN cord-304556-1f47gvys 253 35 and and CC cord-304556-1f47gvys 253 36 microbial microbial JJ cord-304556-1f47gvys 253 37 infections infection NNS cord-304556-1f47gvys 253 38 . . . cord-304556-1f47gvys 254 1 Box box NN cord-304556-1f47gvys 254 2 1 1 CD cord-304556-1f47gvys 254 3 . . . cord-304556-1f47gvys 255 1 Future future JJ cord-304556-1f47gvys 255 2 questions question NNS cord-304556-1f47gvys 255 3 in in IN cord-304556-1f47gvys 255 4 apoptotic apoptotic JJ cord-304556-1f47gvys 255 5 cell cell NN cord-304556-1f47gvys 255 6 removal removal NN cord-304556-1f47gvys 255 7 in in IN cord-304556-1f47gvys 255 8 the the DT cord-304556-1f47gvys 255 9 airspaces airspace NNS cord-304556-1f47gvys 255 10 • • NNP cord-304556-1f47gvys 256 1 Does do VBZ cord-304556-1f47gvys 256 2 efferocytosis efferocytosis NN cord-304556-1f47gvys 256 3 polarise polarise VB cord-304556-1f47gvys 256 4 airway airway NN cord-304556-1f47gvys 256 5 macrophages macrophage NNS cord-304556-1f47gvys 256 6 to to IN cord-304556-1f47gvys 256 7 an an DT cord-304556-1f47gvys 256 8 M2 m2 JJ cord-304556-1f47gvys 256 9 phenotype phenotype NN cord-304556-1f47gvys 256 10 or or CC cord-304556-1f47gvys 256 11 are be VBP cord-304556-1f47gvys 256 12 M2 M2 NNP cord-304556-1f47gvys 256 13 polarised polarised JJ cord-304556-1f47gvys 256 14 airway airway NN cord-304556-1f47gvys 256 15 macrophages macrophage NNS cord-304556-1f47gvys 256 16 better well RBR cord-304556-1f47gvys 256 17 at at IN cord-304556-1f47gvys 256 18 efferocytosis efferocytosis NN cord-304556-1f47gvys 256 19 ? ? . cord-304556-1f47gvys 257 1 • • NNP cord-304556-1f47gvys 258 1 What what WP cord-304556-1f47gvys 258 2 is be VBZ cord-304556-1f47gvys 258 3 the the DT cord-304556-1f47gvys 258 4 impact impact NN cord-304556-1f47gvys 258 5 of of IN cord-304556-1f47gvys 258 6 the the DT cord-304556-1f47gvys 258 7 tissue tissue NN cord-304556-1f47gvys 258 8 microenvironment microenvironment NN cord-304556-1f47gvys 258 9 on on IN cord-304556-1f47gvys 258 10 apoptotic apoptotic JJ cord-304556-1f47gvys 258 11 cell cell NN cord-304556-1f47gvys 258 12 recognition recognition NN cord-304556-1f47gvys 258 13 receptor receptor NN cord-304556-1f47gvys 258 14 repertoires repertoire NNS cord-304556-1f47gvys 258 15 and and CC cord-304556-1f47gvys 258 16 outcome outcome NN cord-304556-1f47gvys 258 17 of of IN cord-304556-1f47gvys 258 18 their -PRON- PRP$ cord-304556-1f47gvys 258 19 ligation ligation NN cord-304556-1f47gvys 258 20 ? ? . cord-304556-1f47gvys 259 1 • • NNP cord-304556-1f47gvys 260 1 Is be VBZ cord-304556-1f47gvys 260 2 homeostatic homeostatic JJ cord-304556-1f47gvys 260 3 apoptotic apoptotic JJ cord-304556-1f47gvys 260 4 cell cell NN cord-304556-1f47gvys 260 5 clearance clearance NN cord-304556-1f47gvys 260 6 different different JJ cord-304556-1f47gvys 260 7 in in IN cord-304556-1f47gvys 260 8 requirements requirement NNS cord-304556-1f47gvys 260 9 and and CC cord-304556-1f47gvys 260 10 consequences consequence NNS cord-304556-1f47gvys 260 11 to to IN cord-304556-1f47gvys 260 12 clearance clearance NN cord-304556-1f47gvys 260 13 of of IN cord-304556-1f47gvys 260 14 cells cell NNS cord-304556-1f47gvys 260 15 during during IN cord-304556-1f47gvys 260 16 inflammation inflammation NN cord-304556-1f47gvys 260 17 ? ? . cord-304556-1f47gvys 261 1 • • NNP cord-304556-1f47gvys 262 1 What what WP cord-304556-1f47gvys 262 2 is be VBZ cord-304556-1f47gvys 262 3 the the DT cord-304556-1f47gvys 262 4 impact impact NN cord-304556-1f47gvys 262 5 of of IN cord-304556-1f47gvys 262 6 the the DT cord-304556-1f47gvys 262 7 altered altered JJ cord-304556-1f47gvys 262 8 lung lung NN cord-304556-1f47gvys 262 9 environment environment NN cord-304556-1f47gvys 262 10 in in IN cord-304556-1f47gvys 262 11 asthma asthma NN cord-304556-1f47gvys 262 12 , , , cord-304556-1f47gvys 262 13 COPD COPD NNP cord-304556-1f47gvys 262 14 and and CC cord-304556-1f47gvys 262 15 CF CF NNP cord-304556-1f47gvys 262 16 on on IN cord-304556-1f47gvys 262 17 apoptotic apoptotic JJ cord-304556-1f47gvys 262 18 cell cell NN cord-304556-1f47gvys 262 19 clearance clearance NN cord-304556-1f47gvys 262 20 ? ? . cord-304556-1f47gvys 263 1 Open open VB cord-304556-1f47gvys 263 2 Access Access NNP cord-304556-1f47gvys 264 1 This this DT cord-304556-1f47gvys 264 2 article article NN cord-304556-1f47gvys 264 3 is be VBZ cord-304556-1f47gvys 264 4 distributed distribute VBN cord-304556-1f47gvys 264 5 under under IN cord-304556-1f47gvys 264 6 the the DT cord-304556-1f47gvys 264 7 terms term NNS cord-304556-1f47gvys 264 8 of of IN cord-304556-1f47gvys 264 9 the the DT cord-304556-1f47gvys 264 10 Creative Creative NNP cord-304556-1f47gvys 264 11 Comm Comm NNP cord-304556-1f47gvys 264 12 ons on NNS cord-304556-1f47gvys 264 13 Attribution Attribution NNP cord-304556-1f47gvys 264 14 4.0 4.0 CD cord-304556-1f47gvys 264 15 International International NNP cord-304556-1f47gvys 264 16 License License NNP cord-304556-1f47gvys 264 17 ( ( -LRB- cord-304556-1f47gvys 264 18 http:// http:// NNP cord-304556-1f47gvys 264 19 creativecommons.org/licenses/by/4.0/ creativecommons.org/licenses/by/4.0/ NNP cord-304556-1f47gvys 264 20 ) ) -RRB- cord-304556-1f47gvys 264 21 , , , cord-304556-1f47gvys 264 22 which which WDT cord-304556-1f47gvys 264 23 permits permit VBZ cord-304556-1f47gvys 264 24 unrestricted unrestricted JJ cord-304556-1f47gvys 264 25 use use NN cord-304556-1f47gvys 264 26 , , , cord-304556-1f47gvys 264 27 distribution distribution NN cord-304556-1f47gvys 264 28 , , , cord-304556-1f47gvys 264 29 and and CC cord-304556-1f47gvys 264 30 reproduction reproduction NN cord-304556-1f47gvys 264 31 in in IN cord-304556-1f47gvys 264 32 any any DT cord-304556-1f47gvys 264 33 medium medium NN cord-304556-1f47gvys 264 34 , , , cord-304556-1f47gvys 264 35 provided provide VBN cord-304556-1f47gvys 264 36 you -PRON- PRP cord-304556-1f47gvys 264 37 give give VBP cord-304556-1f47gvys 264 38 appropriate appropriate JJ cord-304556-1f47gvys 264 39 credit credit NN cord-304556-1f47gvys 264 40 to to IN cord-304556-1f47gvys 264 41 the the DT cord-304556-1f47gvys 264 42 original original JJ cord-304556-1f47gvys 264 43 author(s author(s NNP cord-304556-1f47gvys 264 44 ) ) -RRB- cord-304556-1f47gvys 264 45 and and CC cord-304556-1f47gvys 264 46 the the DT cord-304556-1f47gvys 264 47 source source NN cord-304556-1f47gvys 264 48 , , , cord-304556-1f47gvys 264 49 provide provide VB cord-304556-1f47gvys 264 50 a a DT cord-304556-1f47gvys 264 51 link link NN cord-304556-1f47gvys 264 52 to to IN cord-304556-1f47gvys 264 53 the the DT cord-304556-1f47gvys 264 54 Creative Creative NNP cord-304556-1f47gvys 264 55 Commons Commons NNP cord-304556-1f47gvys 264 56 license license NN cord-304556-1f47gvys 264 57 , , , cord-304556-1f47gvys 264 58 and and CC cord-304556-1f47gvys 264 59 indicate indicate VBP cord-304556-1f47gvys 264 60 if if IN cord-304556-1f47gvys 264 61 changes change NNS cord-304556-1f47gvys 264 62 were be VBD cord-304556-1f47gvys 264 63 made make VBN cord-304556-1f47gvys 264 64 . . . cord-304556-1f47gvys 265 1 Phagocytosis Phagocytosis NNP cord-304556-1f47gvys 265 2 of of IN cord-304556-1f47gvys 265 3 apoptotic apoptotic JJ cord-304556-1f47gvys 265 4 cells cell NNS cord-304556-1f47gvys 265 5 in in IN cord-304556-1f47gvys 265 6 homeostasis homeostasis NN cord-304556-1f47gvys 266 1 The the DT cord-304556-1f47gvys 266 2 Axl Axl NNP cord-304556-1f47gvys 266 3 receptor receptor NN cord-304556-1f47gvys 266 4 tyrosine tyrosine NN cord-304556-1f47gvys 266 5 kinase kinase NN cord-304556-1f47gvys 266 6 is be VBZ cord-304556-1f47gvys 266 7 a a DT cord-304556-1f47gvys 266 8 discriminator discriminator NN cord-304556-1f47gvys 266 9 of of IN cord-304556-1f47gvys 266 10 macrophage macrophage NN cord-304556-1f47gvys 266 11 function function NN cord-304556-1f47gvys 266 12 in in IN cord-304556-1f47gvys 266 13 the the DT cord-304556-1f47gvys 266 14 inflamed inflamed JJ cord-304556-1f47gvys 266 15 lung lung NN cord-304556-1f47gvys 266 16 Nucleotides nucleotide NNS cord-304556-1f47gvys 266 17 released release VBN cord-304556-1f47gvys 266 18 by by IN cord-304556-1f47gvys 266 19 apoptotic apoptotic JJ cord-304556-1f47gvys 266 20 cells cell NNS cord-304556-1f47gvys 266 21 act act VBP cord-304556-1f47gvys 266 22 as as IN cord-304556-1f47gvys 266 23 a a DT cord-304556-1f47gvys 266 24 find find NN cord-304556-1f47gvys 266 25 - - HYPH cord-304556-1f47gvys 266 26 me -PRON- PRP cord-304556-1f47gvys 266 27 signal signal NN cord-304556-1f47gvys 266 28 to to TO cord-304556-1f47gvys 266 29 promote promote VB cord-304556-1f47gvys 266 30 phagocytic phagocytic JJ cord-304556-1f47gvys 266 31 clearance clearance NN cord-304556-1f47gvys 266 32 CX3CL1 cx3cl1 NN cord-304556-1f47gvys 266 33 / / SYM cord-304556-1f47gvys 266 34 fractalkine fractalkine NN cord-304556-1f47gvys 266 35 is be VBZ cord-304556-1f47gvys 266 36 released release VBN cord-304556-1f47gvys 266 37 from from IN cord-304556-1f47gvys 266 38 apoptotic apoptotic JJ cord-304556-1f47gvys 266 39 lymphocytes lymphocyte NNS cord-304556-1f47gvys 266 40 to to TO cord-304556-1f47gvys 266 41 stimulate stimulate VB cord-304556-1f47gvys 266 42 macrophage macrophage NN cord-304556-1f47gvys 266 43 chemotaxis chemotaxis NN cord-304556-1f47gvys 267 1 Apoptotic apoptotic JJ cord-304556-1f47gvys 267 2 cells cell NNS cord-304556-1f47gvys 267 3 induce induce VBP cord-304556-1f47gvys 267 4 migration migration NN cord-304556-1f47gvys 267 5 of of IN cord-304556-1f47gvys 267 6 phagocytes phagocyte NNS cord-304556-1f47gvys 267 7 via via IN cord-304556-1f47gvys 267 8 caspase-3-mediated caspase-3-mediated JJ cord-304556-1f47gvys 267 9 release release NN cord-304556-1f47gvys 267 10 of of IN cord-304556-1f47gvys 267 11 a a DT cord-304556-1f47gvys 267 12 lipid lipid NN cord-304556-1f47gvys 267 13 attraction attraction NN cord-304556-1f47gvys 267 14 signal signal NN cord-304556-1f47gvys 268 1 Apoptosis apoptosis NN cord-304556-1f47gvys 268 2 induces induce VBZ cord-304556-1f47gvys 268 3 expression expression NN cord-304556-1f47gvys 268 4 of of IN cord-304556-1f47gvys 268 5 sphingosine sphingosine NNP cord-304556-1f47gvys 268 6 kinase kinase NNP cord-304556-1f47gvys 268 7 1 1 CD cord-304556-1f47gvys 268 8 to to TO cord-304556-1f47gvys 268 9 release release VB cord-304556-1f47gvys 268 10 sphingosine-1-phosphate sphingosine-1-phosphate RB cord-304556-1f47gvys 268 11 as as IN cord-304556-1f47gvys 268 12 a a DT cord-304556-1f47gvys 268 13 " " `` cord-304556-1f47gvys 268 14 come come VB cord-304556-1f47gvys 268 15 - - HYPH cord-304556-1f47gvys 268 16 and and CC cord-304556-1f47gvys 268 17 - - HYPH cord-304556-1f47gvys 268 18 get get VB cord-304556-1f47gvys 268 19 - - HYPH cord-304556-1f47gvys 268 20 me -PRON- PRP cord-304556-1f47gvys 268 21 " " '' cord-304556-1f47gvys 268 22 signal signal JJ cord-304556-1f47gvys 268 23 Fractalkine Fractalkine NNP cord-304556-1f47gvys 268 24 - - HYPH cord-304556-1f47gvys 268 25 induced induce VBN cord-304556-1f47gvys 268 26 MFG MFG NNP cord-304556-1f47gvys 268 27 - - HYPH cord-304556-1f47gvys 268 28 E8 E8 NNP cord-304556-1f47gvys 268 29 leads lead VBZ cord-304556-1f47gvys 268 30 to to IN cord-304556-1f47gvys 268 31 enhanced enhance VBN cord-304556-1f47gvys 268 32 apoptotic apoptotic JJ cord-304556-1f47gvys 268 33 cell cell NN cord-304556-1f47gvys 268 34 clearance clearance NN cord-304556-1f47gvys 268 35 by by IN cord-304556-1f47gvys 268 36 macrophages macrophage NNS cord-304556-1f47gvys 268 37 Dangerous dangerous JJ cord-304556-1f47gvys 268 38 attraction attraction NN cord-304556-1f47gvys 268 39 : : : cord-304556-1f47gvys 269 1 phagocyte phagocyte NNP cord-304556-1f47gvys 269 2 recruitment recruitment NNP cord-304556-1f47gvys 269 3 and and CC cord-304556-1f47gvys 269 4 danger danger NN cord-304556-1f47gvys 269 5 signals signal NNS cord-304556-1f47gvys 269 6 of of IN cord-304556-1f47gvys 269 7 apoptotic apoptotic JJ cord-304556-1f47gvys 269 8 and and CC cord-304556-1f47gvys 269 9 necrotic necrotic JJ cord-304556-1f47gvys 269 10 cells cell NNS cord-304556-1f47gvys 270 1 The the DT cord-304556-1f47gvys 270 2 distribution distribution NN cord-304556-1f47gvys 270 3 and and CC cord-304556-1f47gvys 270 4 function function NN cord-304556-1f47gvys 270 5 of of IN cord-304556-1f47gvys 270 6 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 270 7 in in IN cord-304556-1f47gvys 270 8 cellular cellular JJ cord-304556-1f47gvys 270 9 membranes membrane NNS cord-304556-1f47gvys 270 10 Masking mask VBG cord-304556-1f47gvys 270 11 of of IN cord-304556-1f47gvys 270 12 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 270 13 inhibits inhibit VBZ cord-304556-1f47gvys 270 14 apoptotic apoptotic JJ cord-304556-1f47gvys 270 15 cell cell NN cord-304556-1f47gvys 270 16 engulfment engulfment NN cord-304556-1f47gvys 270 17 and and CC cord-304556-1f47gvys 270 18 induces induce VBZ cord-304556-1f47gvys 270 19 autoantibody autoantibody NNP cord-304556-1f47gvys 270 20 production production NN cord-304556-1f47gvys 270 21 in in IN cord-304556-1f47gvys 270 22 mice mouse NNS cord-304556-1f47gvys 271 1 In in IN cord-304556-1f47gvys 271 2 vivo vivo NN cord-304556-1f47gvys 271 3 recognition recognition NN cord-304556-1f47gvys 271 4 and and CC cord-304556-1f47gvys 271 5 clearance clearance NN cord-304556-1f47gvys 271 6 of of IN cord-304556-1f47gvys 271 7 red red JJ cord-304556-1f47gvys 271 8 blood blood NN cord-304556-1f47gvys 271 9 cells cell NNS cord-304556-1f47gvys 271 10 containing contain VBG cord-304556-1f47gvys 271 11 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 271 12 in in IN cord-304556-1f47gvys 271 13 their -PRON- PRP$ cord-304556-1f47gvys 271 14 plasma plasma NN cord-304556-1f47gvys 271 15 membranes membrane NNS cord-304556-1f47gvys 271 16 Caspase Caspase NNP cord-304556-1f47gvys 271 17 - - HYPH cord-304556-1f47gvys 271 18 mediated mediate VBN cord-304556-1f47gvys 271 19 cleavage cleavage NN cord-304556-1f47gvys 271 20 of of IN cord-304556-1f47gvys 271 21 phospholipid phospholipid NN cord-304556-1f47gvys 271 22 flippase flippase NN cord-304556-1f47gvys 271 23 for for IN cord-304556-1f47gvys 271 24 apoptotic apoptotic JJ cord-304556-1f47gvys 271 25 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 271 26 exposure exposure NN cord-304556-1f47gvys 271 27 Xk Xk NNP cord-304556-1f47gvys 271 28 - - HYPH cord-304556-1f47gvys 271 29 related relate VBN cord-304556-1f47gvys 271 30 protein protein NN cord-304556-1f47gvys 271 31 8 8 CD cord-304556-1f47gvys 271 32 and and CC cord-304556-1f47gvys 271 33 CED-8 CED-8 NNP cord-304556-1f47gvys 271 34 promote promote VBP cord-304556-1f47gvys 271 35 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 271 36 exposure exposure NN cord-304556-1f47gvys 271 37 in in IN cord-304556-1f47gvys 271 38 apoptotic apoptotic JJ cord-304556-1f47gvys 271 39 cells cell NNS cord-304556-1f47gvys 272 1 Find find VB cord-304556-1f47gvys 272 2 - - HYPH cord-304556-1f47gvys 272 3 me -PRON- PRP cord-304556-1f47gvys 272 4 and and CC cord-304556-1f47gvys 272 5 eat eat VB cord-304556-1f47gvys 272 6 - - HYPH cord-304556-1f47gvys 272 7 me -PRON- PRP cord-304556-1f47gvys 272 8 signals signal NNS cord-304556-1f47gvys 272 9 in in IN cord-304556-1f47gvys 272 10 apoptotic apoptotic JJ cord-304556-1f47gvys 272 11 cell cell NN cord-304556-1f47gvys 272 12 clearance clearance NN cord-304556-1f47gvys 272 13 : : : cord-304556-1f47gvys 272 14 progress progress NN cord-304556-1f47gvys 272 15 and and CC cord-304556-1f47gvys 272 16 conundrums conundrum NNS cord-304556-1f47gvys 273 1 The the DT cord-304556-1f47gvys 273 2 interaction interaction NN cord-304556-1f47gvys 273 3 between between IN cord-304556-1f47gvys 273 4 signal signal JJ cord-304556-1f47gvys 273 5 regulatory regulatory JJ cord-304556-1f47gvys 273 6 protein protein NN cord-304556-1f47gvys 273 7 alpha alpha NN cord-304556-1f47gvys 273 8 ( ( -LRB- cord-304556-1f47gvys 273 9 SIRPalpha SIRPalpha NNP cord-304556-1f47gvys 273 10 ) ) -RRB- cord-304556-1f47gvys 273 11 and and CC cord-304556-1f47gvys 273 12 CD47 CD47 NNP cord-304556-1f47gvys 273 13 : : : cord-304556-1f47gvys 273 14 structure structure NN cord-304556-1f47gvys 273 15 , , , cord-304556-1f47gvys 273 16 function function NN cord-304556-1f47gvys 273 17 , , , cord-304556-1f47gvys 273 18 and and CC cord-304556-1f47gvys 273 19 therapeutic therapeutic JJ cord-304556-1f47gvys 273 20 target target NN cord-304556-1f47gvys 274 1 Apoptosis apoptosis NN cord-304556-1f47gvys 274 2 disables disable VBZ cord-304556-1f47gvys 274 3 CD31-mediated cd31-mediated JJ cord-304556-1f47gvys 274 4 cell cell NN cord-304556-1f47gvys 274 5 detachment detachment NN cord-304556-1f47gvys 274 6 from from IN cord-304556-1f47gvys 274 7 phagocytes phagocyte NNS cord-304556-1f47gvys 274 8 promoting promote VBG cord-304556-1f47gvys 274 9 binding binding NN cord-304556-1f47gvys 274 10 and and CC cord-304556-1f47gvys 274 11 engulfment engulfment NN cord-304556-1f47gvys 274 12 Human Human NNP cord-304556-1f47gvys 274 13 CD300a CD300a NNP cord-304556-1f47gvys 274 14 binds bind VBZ cord-304556-1f47gvys 274 15 to to IN cord-304556-1f47gvys 274 16 phosphatidylethanolamine phosphatidylethanolamine NN cord-304556-1f47gvys 274 17 and and CC cord-304556-1f47gvys 274 18 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 274 19 , , , cord-304556-1f47gvys 274 20 and and CC cord-304556-1f47gvys 274 21 modulates modulate VBZ cord-304556-1f47gvys 274 22 the the DT cord-304556-1f47gvys 274 23 phagocytosis phagocytosis NN cord-304556-1f47gvys 274 24 of of IN cord-304556-1f47gvys 274 25 dead dead JJ cord-304556-1f47gvys 274 26 cells cell NNS cord-304556-1f47gvys 274 27 Overexpression Overexpression NNP cord-304556-1f47gvys 274 28 of of IN cord-304556-1f47gvys 274 29 apoptotic apoptotic JJ cord-304556-1f47gvys 274 30 cell cell NN cord-304556-1f47gvys 274 31 removal removal NN cord-304556-1f47gvys 274 32 receptor receptor NN cord-304556-1f47gvys 274 33 MERTK MERTK NNP cord-304556-1f47gvys 274 34 in in IN cord-304556-1f47gvys 274 35 alveolar alveolar JJ cord-304556-1f47gvys 274 36 macrophages macrophage NNS cord-304556-1f47gvys 274 37 of of IN cord-304556-1f47gvys 274 38 cigarette cigarette NN cord-304556-1f47gvys 274 39 smokers smoker NNS cord-304556-1f47gvys 274 40 RAGE rage VBP cord-304556-1f47gvys 275 1 signaling signal VBG cord-304556-1f47gvys 275 2 by by IN cord-304556-1f47gvys 275 3 alveolar alveolar JJ cord-304556-1f47gvys 275 4 macrophages macrophage NNS cord-304556-1f47gvys 275 5 influences influence VBZ cord-304556-1f47gvys 275 6 tobacco tobacco NN cord-304556-1f47gvys 275 7 smoke smoke NN cord-304556-1f47gvys 275 8 - - HYPH cord-304556-1f47gvys 275 9 induced induce VBN cord-304556-1f47gvys 275 10 inflammation inflammation NN cord-304556-1f47gvys 275 11 Expression expression NN cord-304556-1f47gvys 275 12 of of IN cord-304556-1f47gvys 275 13 high high JJ cord-304556-1f47gvys 275 14 - - HYPH cord-304556-1f47gvys 275 15 mobility mobility NN cord-304556-1f47gvys 275 16 group group NN cord-304556-1f47gvys 275 17 box box NN cord-304556-1f47gvys 275 18 1 1 CD cord-304556-1f47gvys 275 19 and and CC cord-304556-1f47gvys 275 20 of of IN cord-304556-1f47gvys 275 21 receptor receptor NN cord-304556-1f47gvys 275 22 for for IN cord-304556-1f47gvys 275 23 advanced advanced JJ cord-304556-1f47gvys 275 24 glycation glycation NN cord-304556-1f47gvys 275 25 end end NN cord-304556-1f47gvys 275 26 products product NNS cord-304556-1f47gvys 275 27 in in IN cord-304556-1f47gvys 275 28 chronic chronic JJ cord-304556-1f47gvys 275 29 obstructive obstructive JJ cord-304556-1f47gvys 275 30 pulmonary pulmonary JJ cord-304556-1f47gvys 275 31 disease disease NN cord-304556-1f47gvys 276 1 Azithromycin azithromycin NN cord-304556-1f47gvys 276 2 increases increase VBZ cord-304556-1f47gvys 276 3 phagocytosis phagocytosis NN cord-304556-1f47gvys 276 4 of of IN cord-304556-1f47gvys 276 5 apoptotic apoptotic JJ cord-304556-1f47gvys 276 6 bronchial bronchial JJ cord-304556-1f47gvys 276 7 epithelial epithelial JJ cord-304556-1f47gvys 276 8 cells cell NNS cord-304556-1f47gvys 276 9 by by IN cord-304556-1f47gvys 276 10 alveolar alveolar NN cord-304556-1f47gvys 276 11 macrophages macrophage NNS cord-304556-1f47gvys 277 1 Smoking smoking NN cord-304556-1f47gvys 277 2 alters alter VBZ cord-304556-1f47gvys 277 3 alveolar alveolar NN cord-304556-1f47gvys 277 4 macrophage macrophage NN cord-304556-1f47gvys 277 5 recognition recognition NN cord-304556-1f47gvys 277 6 and and CC cord-304556-1f47gvys 277 7 phagocytic phagocytic JJ cord-304556-1f47gvys 277 8 ability ability NN cord-304556-1f47gvys 277 9 : : : cord-304556-1f47gvys 277 10 implications implication NNS cord-304556-1f47gvys 277 11 in in IN cord-304556-1f47gvys 277 12 chronic chronic JJ cord-304556-1f47gvys 277 13 obstructive obstructive JJ cord-304556-1f47gvys 277 14 pulmonary pulmonary JJ cord-304556-1f47gvys 277 15 disease disease NN cord-304556-1f47gvys 278 1 TREM-2 TREM-2 NNP cord-304556-1f47gvys 278 2 promotes promote VBZ cord-304556-1f47gvys 278 3 macrophage macrophage NN cord-304556-1f47gvys 278 4 survival survival NN cord-304556-1f47gvys 278 5 and and CC cord-304556-1f47gvys 278 6 lung lung NN cord-304556-1f47gvys 278 7 disease disease NN cord-304556-1f47gvys 278 8 after after IN cord-304556-1f47gvys 278 9 respiratory respiratory JJ cord-304556-1f47gvys 278 10 viral viral JJ cord-304556-1f47gvys 278 11 infection infection NN cord-304556-1f47gvys 278 12 Priming priming NN cord-304556-1f47gvys 278 13 of of IN cord-304556-1f47gvys 278 14 alveolar alveolar JJ cord-304556-1f47gvys 278 15 macrophages macrophage NNS cord-304556-1f47gvys 278 16 upon upon IN cord-304556-1f47gvys 278 17 instillation instillation NN cord-304556-1f47gvys 278 18 of of IN cord-304556-1f47gvys 278 19 lipopolysaccharide lipopolysaccharide NN cord-304556-1f47gvys 278 20 in in IN cord-304556-1f47gvys 278 21 the the DT cord-304556-1f47gvys 278 22 human human JJ cord-304556-1f47gvys 278 23 lung lung NN cord-304556-1f47gvys 278 24 Elastase Elastase NNP cord-304556-1f47gvys 278 25 - - HYPH cord-304556-1f47gvys 278 26 mediated mediate VBN cord-304556-1f47gvys 278 27 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 278 28 receptor receptor NN cord-304556-1f47gvys 278 29 cleavage cleavage NN cord-304556-1f47gvys 278 30 impairs impair VBZ cord-304556-1f47gvys 278 31 apoptotic apoptotic JJ cord-304556-1f47gvys 278 32 cell cell NN cord-304556-1f47gvys 278 33 clearance clearance NN cord-304556-1f47gvys 278 34 in in IN cord-304556-1f47gvys 278 35 cystic cystic JJ cord-304556-1f47gvys 278 36 fibrosis fibrosis NN cord-304556-1f47gvys 278 37 and and CC cord-304556-1f47gvys 278 38 bronchiectasis bronchiectasis NNP cord-304556-1f47gvys 278 39 Flow flow VB cord-304556-1f47gvys 278 40 cytometric cytometric NN cord-304556-1f47gvys 278 41 analysis analysis NN cord-304556-1f47gvys 278 42 of of IN cord-304556-1f47gvys 278 43 macrophages macrophage NNS cord-304556-1f47gvys 278 44 and and CC cord-304556-1f47gvys 278 45 dendritic dendritic JJ cord-304556-1f47gvys 278 46 cell cell NN cord-304556-1f47gvys 278 47 subsets subset NNS cord-304556-1f47gvys 278 48 in in IN cord-304556-1f47gvys 278 49 the the DT cord-304556-1f47gvys 278 50 mouse mouse NN cord-304556-1f47gvys 278 51 lung lung NN cord-304556-1f47gvys 278 52 Phenotypic phenotypic JJ cord-304556-1f47gvys 278 53 characterisation characterisation NN cord-304556-1f47gvys 278 54 of of IN cord-304556-1f47gvys 278 55 alveolar alveolar JJ cord-304556-1f47gvys 278 56 macrophages macrophage NNS cord-304556-1f47gvys 278 57 and and CC cord-304556-1f47gvys 278 58 peripheral peripheral JJ cord-304556-1f47gvys 278 59 blood blood NN cord-304556-1f47gvys 278 60 monocytes monocyte NNS cord-304556-1f47gvys 278 61 in in IN cord-304556-1f47gvys 278 62 COPD COPD NNP cord-304556-1f47gvys 279 1 Azithromycin Azithromycin NNP cord-304556-1f47gvys 279 2 improves improve VBZ cord-304556-1f47gvys 279 3 macrophage macrophage NN cord-304556-1f47gvys 279 4 phagocytic phagocytic JJ cord-304556-1f47gvys 279 5 function function NN cord-304556-1f47gvys 279 6 and and CC cord-304556-1f47gvys 279 7 expression expression NN cord-304556-1f47gvys 279 8 of of IN cord-304556-1f47gvys 279 9 mannose mannose JJ cord-304556-1f47gvys 279 10 receptor receptor NN cord-304556-1f47gvys 279 11 in in IN cord-304556-1f47gvys 279 12 chronic chronic JJ cord-304556-1f47gvys 279 13 obstructive obstructive JJ cord-304556-1f47gvys 279 14 pulmonary pulmonary JJ cord-304556-1f47gvys 279 15 disease disease NN cord-304556-1f47gvys 279 16 Role role NN cord-304556-1f47gvys 279 17 of of IN cord-304556-1f47gvys 279 18 surfactant surfactant NN cord-304556-1f47gvys 279 19 proteins protein NNS cord-304556-1f47gvys 279 20 A A NNP cord-304556-1f47gvys 279 21 , , , cord-304556-1f47gvys 279 22 D D NNP cord-304556-1f47gvys 279 23 , , , cord-304556-1f47gvys 279 24 and and CC cord-304556-1f47gvys 279 25 C1q C1q NNP cord-304556-1f47gvys 279 26 in in IN cord-304556-1f47gvys 279 27 the the DT cord-304556-1f47gvys 279 28 clearance clearance NN cord-304556-1f47gvys 279 29 of of IN cord-304556-1f47gvys 279 30 apoptotic apoptotic JJ cord-304556-1f47gvys 279 31 cells cell NNS cord-304556-1f47gvys 279 32 in in IN cord-304556-1f47gvys 279 33 vivo vivo NN cord-304556-1f47gvys 279 34 and and CC cord-304556-1f47gvys 279 35 in in IN cord-304556-1f47gvys 279 36 vitro vitro FW cord-304556-1f47gvys 279 37 : : : cord-304556-1f47gvys 279 38 calreticulin calreticulin NNP cord-304556-1f47gvys 279 39 and and CC cord-304556-1f47gvys 279 40 CD91 CD91 NNP cord-304556-1f47gvys 279 41 as as IN cord-304556-1f47gvys 279 42 a a DT cord-304556-1f47gvys 279 43 common common JJ cord-304556-1f47gvys 279 44 collectin collectin NN cord-304556-1f47gvys 279 45 receptor receptor NN cord-304556-1f47gvys 279 46 complex complex JJ cord-304556-1f47gvys 279 47 Clearance clearance NN cord-304556-1f47gvys 279 48 of of IN cord-304556-1f47gvys 279 49 apoptotic apoptotic JJ cord-304556-1f47gvys 279 50 neurons neuron NNS cord-304556-1f47gvys 279 51 without without IN cord-304556-1f47gvys 279 52 inflammation inflammation NN cord-304556-1f47gvys 279 53 by by IN cord-304556-1f47gvys 279 54 microglial microglial JJ cord-304556-1f47gvys 279 55 triggering trigger VBG cord-304556-1f47gvys 279 56 receptor receptor NN cord-304556-1f47gvys 279 57 expressed express VBN cord-304556-1f47gvys 279 58 on on IN cord-304556-1f47gvys 279 59 myeloid myeloid NN cord-304556-1f47gvys 279 60 cells-2 cells-2 IN cord-304556-1f47gvys 279 61 CD300b CD300b NNP cord-304556-1f47gvys 279 62 regulates regulate VBZ cord-304556-1f47gvys 279 63 the the DT cord-304556-1f47gvys 279 64 phagocytosis phagocytosis NN cord-304556-1f47gvys 279 65 of of IN cord-304556-1f47gvys 279 66 apoptotic apoptotic JJ cord-304556-1f47gvys 279 67 cells cell NNS cord-304556-1f47gvys 279 68 via via IN cord-304556-1f47gvys 279 69 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 279 70 recognition recognition NN cord-304556-1f47gvys 279 71 Participation Participation NNP cord-304556-1f47gvys 279 72 of of IN cord-304556-1f47gvys 279 73 the the DT cord-304556-1f47gvys 279 74 receptor receptor NN cord-304556-1f47gvys 279 75 for for IN cord-304556-1f47gvys 279 76 advanced advanced JJ cord-304556-1f47gvys 279 77 glycation glycation NN cord-304556-1f47gvys 279 78 end end NN cord-304556-1f47gvys 279 79 products product NNS cord-304556-1f47gvys 279 80 in in IN cord-304556-1f47gvys 279 81 efferocytosis efferocytosis NNP cord-304556-1f47gvys 279 82 Rapid Rapid NNP cord-304556-1f47gvys 279 83 cell cell NN cord-304556-1f47gvys 279 84 corpse corpse NN cord-304556-1f47gvys 279 85 clearance clearance NN cord-304556-1f47gvys 279 86 by by IN cord-304556-1f47gvys 279 87 stabilin-2 stabilin-2 NNP cord-304556-1f47gvys 279 88 , , , cord-304556-1f47gvys 280 1 a a DT cord-304556-1f47gvys 280 2 membrane membrane NN cord-304556-1f47gvys 280 3 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 280 4 receptor receptor NN cord-304556-1f47gvys 280 5 BAI1 BAI1 NNP cord-304556-1f47gvys 280 6 is be VBZ cord-304556-1f47gvys 280 7 an an DT cord-304556-1f47gvys 280 8 engulfment engulfment NN cord-304556-1f47gvys 280 9 receptor receptor NN cord-304556-1f47gvys 280 10 for for IN cord-304556-1f47gvys 280 11 apoptotic apoptotic JJ cord-304556-1f47gvys 280 12 cells cell NNS cord-304556-1f47gvys 280 13 upstream upstream RB cord-304556-1f47gvys 280 14 of of IN cord-304556-1f47gvys 280 15 the the DT cord-304556-1f47gvys 280 16 ELMO ELMO NNP cord-304556-1f47gvys 280 17 / / SYM cord-304556-1f47gvys 280 18 Dock180 Dock180 NNP cord-304556-1f47gvys 280 19 / / SYM cord-304556-1f47gvys 280 20 Rac Rac NNP cord-304556-1f47gvys 280 21 module module NN cord-304556-1f47gvys 280 22 Identification identification NN cord-304556-1f47gvys 280 23 of of IN cord-304556-1f47gvys 280 24 Tim4 Tim4 NNP cord-304556-1f47gvys 280 25 as as IN cord-304556-1f47gvys 280 26 a a DT cord-304556-1f47gvys 280 27 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 280 28 receptor receptor NN cord-304556-1f47gvys 280 29 TIM-1 TIM-1 NNP cord-304556-1f47gvys 280 30 and and CC cord-304556-1f47gvys 280 31 TIM-4 TIM-4 NNP cord-304556-1f47gvys 280 32 glycoproteins glycoprotein NNS cord-304556-1f47gvys 280 33 bind bind VBP cord-304556-1f47gvys 280 34 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 280 35 and and CC cord-304556-1f47gvys 280 36 mediate mediate VB cord-304556-1f47gvys 280 37 uptake uptake NN cord-304556-1f47gvys 280 38 of of IN cord-304556-1f47gvys 280 39 apoptotic apoptotic JJ cord-304556-1f47gvys 280 40 cells cell NNS cord-304556-1f47gvys 280 41 Biology biology NN cord-304556-1f47gvys 280 42 of of IN cord-304556-1f47gvys 280 43 the the DT cord-304556-1f47gvys 280 44 TAM TAM NNP cord-304556-1f47gvys 280 45 receptors receptor NNS cord-304556-1f47gvys 281 1 The the DT cord-304556-1f47gvys 281 2 anticoagulation anticoagulation NN cord-304556-1f47gvys 281 3 factor factor NN cord-304556-1f47gvys 281 4 protein protein NN cord-304556-1f47gvys 281 5 S S NNP cord-304556-1f47gvys 281 6 and and CC cord-304556-1f47gvys 281 7 its -PRON- PRP$ cord-304556-1f47gvys 281 8 relative relative NN cord-304556-1f47gvys 281 9 , , , cord-304556-1f47gvys 282 1 Gas6 gas6 NN cord-304556-1f47gvys 282 2 , , , cord-304556-1f47gvys 282 3 are be VBP cord-304556-1f47gvys 282 4 ligands ligand NNS cord-304556-1f47gvys 282 5 for for IN cord-304556-1f47gvys 282 6 the the DT cord-304556-1f47gvys 282 7 Tyro Tyro NNP cord-304556-1f47gvys 282 8 3 3 CD cord-304556-1f47gvys 282 9 / / SYM cord-304556-1f47gvys 282 10 Axl Axl NNP cord-304556-1f47gvys 282 11 family family NN cord-304556-1f47gvys 282 12 of of IN cord-304556-1f47gvys 282 13 receptor receptor NN cord-304556-1f47gvys 282 14 tyrosine tyrosine NN cord-304556-1f47gvys 282 15 kinases kinase NNS cord-304556-1f47gvys 282 16 Beginnings beginning NNS cord-304556-1f47gvys 282 17 of of IN cord-304556-1f47gvys 282 18 a a DT cord-304556-1f47gvys 282 19 good good JJ cord-304556-1f47gvys 282 20 apoptotic apoptotic JJ cord-304556-1f47gvys 282 21 meal meal NN cord-304556-1f47gvys 282 22 : : : cord-304556-1f47gvys 282 23 the the DT cord-304556-1f47gvys 282 24 find find NN cord-304556-1f47gvys 282 25 - - HYPH cord-304556-1f47gvys 282 26 me -PRON- PRP cord-304556-1f47gvys 282 27 and and CC cord-304556-1f47gvys 282 28 eat eat VB cord-304556-1f47gvys 282 29 - - : cord-304556-1f47gvys 282 30 me -PRON- PRP cord-304556-1f47gvys 282 31 signaling signal VBG cord-304556-1f47gvys 282 32 pathways pathway NNS cord-304556-1f47gvys 283 1 Identification identification NN cord-304556-1f47gvys 283 2 of of IN cord-304556-1f47gvys 283 3 the the DT cord-304556-1f47gvys 283 4 product product NN cord-304556-1f47gvys 283 5 of of IN cord-304556-1f47gvys 283 6 growth growth NN cord-304556-1f47gvys 283 7 arrest arrest NN cord-304556-1f47gvys 283 8 - - HYPH cord-304556-1f47gvys 283 9 specific specific JJ cord-304556-1f47gvys 283 10 gene gene NN cord-304556-1f47gvys 283 11 6 6 CD cord-304556-1f47gvys 283 12 as as IN cord-304556-1f47gvys 283 13 a a DT cord-304556-1f47gvys 283 14 common common JJ cord-304556-1f47gvys 283 15 ligand ligand NN cord-304556-1f47gvys 283 16 for for IN cord-304556-1f47gvys 283 17 Axl Axl NNP cord-304556-1f47gvys 283 18 , , , cord-304556-1f47gvys 283 19 Sky Sky NNP cord-304556-1f47gvys 283 20 , , , cord-304556-1f47gvys 283 21 and and CC cord-304556-1f47gvys 283 22 Mer Mer NNP cord-304556-1f47gvys 283 23 receptor receptor NN cord-304556-1f47gvys 283 24 tyrosine tyrosine NN cord-304556-1f47gvys 283 25 kinases kinase NNS cord-304556-1f47gvys 284 1 The the DT cord-304556-1f47gvys 284 2 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 284 3 receptor receptor NN cord-304556-1f47gvys 284 4 TIM-4 TIM-4 NNP cord-304556-1f47gvys 284 5 does do VBZ cord-304556-1f47gvys 284 6 not not RB cord-304556-1f47gvys 284 7 mediate mediate VB cord-304556-1f47gvys 284 8 direct direct JJ cord-304556-1f47gvys 284 9 signaling signaling NN cord-304556-1f47gvys 285 1 Human Human NNP cord-304556-1f47gvys 285 2 CD14 CD14 NNP cord-304556-1f47gvys 285 3 mediates mediate VBZ cord-304556-1f47gvys 285 4 recognition recognition NN cord-304556-1f47gvys 285 5 and and CC cord-304556-1f47gvys 285 6 phagocytosis phagocytosis NN cord-304556-1f47gvys 285 7 of of IN cord-304556-1f47gvys 285 8 apoptotic apoptotic JJ cord-304556-1f47gvys 285 9 cells cell NNS cord-304556-1f47gvys 286 1 Distinct distinct JJ cord-304556-1f47gvys 286 2 roles role NNS cord-304556-1f47gvys 286 3 for for IN cord-304556-1f47gvys 286 4 BAI1 BAI1 NNP cord-304556-1f47gvys 286 5 and and CC cord-304556-1f47gvys 286 6 TIM-4 TIM-4 NNP cord-304556-1f47gvys 286 7 in in IN cord-304556-1f47gvys 286 8 the the DT cord-304556-1f47gvys 286 9 engulfment engulfment NN cord-304556-1f47gvys 286 10 of of IN cord-304556-1f47gvys 286 11 dying die VBG cord-304556-1f47gvys 286 12 neurons neuron NNS cord-304556-1f47gvys 286 13 by by IN cord-304556-1f47gvys 286 14 microglia microglia VBG cord-304556-1f47gvys 286 15 A a DT cord-304556-1f47gvys 286 16 role role NN cord-304556-1f47gvys 286 17 for for IN cord-304556-1f47gvys 286 18 TREM2 TREM2 NNP cord-304556-1f47gvys 286 19 ligands ligand NNS cord-304556-1f47gvys 286 20 in in IN cord-304556-1f47gvys 286 21 the the DT cord-304556-1f47gvys 286 22 phagocytosis phagocytosis NN cord-304556-1f47gvys 286 23 of of IN cord-304556-1f47gvys 286 24 apoptotic apoptotic JJ cord-304556-1f47gvys 286 25 neuronal neuronal JJ cord-304556-1f47gvys 286 26 cells cell NNS cord-304556-1f47gvys 286 27 by by IN cord-304556-1f47gvys 286 28 microglia microglia NNP cord-304556-1f47gvys 287 1 The the DT cord-304556-1f47gvys 287 2 resolution resolution NN cord-304556-1f47gvys 287 3 of of IN cord-304556-1f47gvys 287 4 inflammation inflammation NN cord-304556-1f47gvys 287 5 : : : cord-304556-1f47gvys 287 6 principles principle NNS cord-304556-1f47gvys 287 7 and and CC cord-304556-1f47gvys 287 8 challenges challenge VBZ cord-304556-1f47gvys 287 9 Diversification diversification NN cord-304556-1f47gvys 287 10 of of IN cord-304556-1f47gvys 287 11 TAM TAM NNP cord-304556-1f47gvys 287 12 receptor receptor NN cord-304556-1f47gvys 287 13 tyrosine tyrosine NN cord-304556-1f47gvys 287 14 kinase kinase NN cord-304556-1f47gvys 287 15 function function NN cord-304556-1f47gvys 288 1 Differential differential JJ cord-304556-1f47gvys 288 2 TAM TAM NNP cord-304556-1f47gvys 288 3 receptor receptor NN cord-304556-1f47gvys 288 4 - - HYPH cord-304556-1f47gvys 288 5 ligand ligand NN cord-304556-1f47gvys 288 6 - - HYPH cord-304556-1f47gvys 288 7 phospholipid phospholipid NN cord-304556-1f47gvys 288 8 interactions interaction NNS cord-304556-1f47gvys 288 9 delimit delimit VBP cord-304556-1f47gvys 288 10 differential differential JJ cord-304556-1f47gvys 288 11 TAM tam NN cord-304556-1f47gvys 288 12 bioactivities bioactivitie NNS cord-304556-1f47gvys 289 1 An an DT cord-304556-1f47gvys 289 2 AXL AXL NNP cord-304556-1f47gvys 289 3 / / SYM cord-304556-1f47gvys 289 4 LRP-1/ lrp-1/ NN cord-304556-1f47gvys 289 5 RANBP9 RANBP9 NNP cord-304556-1f47gvys 289 6 complex complex NNP cord-304556-1f47gvys 289 7 mediates mediate VBZ cord-304556-1f47gvys 289 8 DC DC NNP cord-304556-1f47gvys 289 9 efferocytosis efferocytosis NN cord-304556-1f47gvys 289 10 and and CC cord-304556-1f47gvys 289 11 antigen antigen NN cord-304556-1f47gvys 289 12 cross cross JJ cord-304556-1f47gvys 289 13 - - NN cord-304556-1f47gvys 289 14 presentation presentation NN cord-304556-1f47gvys 289 15 in in IN cord-304556-1f47gvys 289 16 vivo vivo NN cord-304556-1f47gvys 290 1 TAM TAM NNP cord-304556-1f47gvys 290 2 receptors receptor NNS cord-304556-1f47gvys 290 3 are be VBP cord-304556-1f47gvys 290 4 pleiotropic pleiotropic JJ cord-304556-1f47gvys 290 5 inhibitors inhibitor NNS cord-304556-1f47gvys 290 6 of of IN cord-304556-1f47gvys 290 7 the the DT cord-304556-1f47gvys 290 8 innate innate JJ cord-304556-1f47gvys 290 9 immune immune JJ cord-304556-1f47gvys 290 10 response response NN cord-304556-1f47gvys 290 11 Immunosuppressive immunosuppressive JJ cord-304556-1f47gvys 290 12 effects effect NNS cord-304556-1f47gvys 290 13 of of IN cord-304556-1f47gvys 290 14 apoptotic apoptotic JJ cord-304556-1f47gvys 290 15 cells cell NNS cord-304556-1f47gvys 291 1 Interleukin-10 Interleukin-10 NNP cord-304556-1f47gvys 291 2 expression expression NN cord-304556-1f47gvys 291 3 in in IN cord-304556-1f47gvys 291 4 macrophages macrophage NNS cord-304556-1f47gvys 291 5 during during IN cord-304556-1f47gvys 291 6 phagocytosis phagocytosis NN cord-304556-1f47gvys 291 7 of of IN cord-304556-1f47gvys 291 8 apoptotic apoptotic JJ cord-304556-1f47gvys 291 9 cells cell NNS cord-304556-1f47gvys 291 10 is be VBZ cord-304556-1f47gvys 291 11 mediated mediate VBN cord-304556-1f47gvys 291 12 by by IN cord-304556-1f47gvys 291 13 homeodomain homeodomain NNP cord-304556-1f47gvys 291 14 proteins protein NNS cord-304556-1f47gvys 291 15 Pbx1 Pbx1 NNP cord-304556-1f47gvys 291 16 and and CC cord-304556-1f47gvys 291 17 Prep-1 Prep-1 NNP cord-304556-1f47gvys 291 18 Transcriptional Transcriptional NNP cord-304556-1f47gvys 291 19 and and CC cord-304556-1f47gvys 291 20 translational translational JJ cord-304556-1f47gvys 291 21 regulation regulation NN cord-304556-1f47gvys 291 22 of of IN cord-304556-1f47gvys 291 23 inflammatory inflammatory JJ cord-304556-1f47gvys 291 24 mediator mediator NN cord-304556-1f47gvys 291 25 production production NN cord-304556-1f47gvys 291 26 by by IN cord-304556-1f47gvys 291 27 endogenous endogenous JJ cord-304556-1f47gvys 291 28 TGF TGF NNP cord-304556-1f47gvys 291 29 - - HYPH cord-304556-1f47gvys 291 30 beta beta NN cord-304556-1f47gvys 291 31 in in IN cord-304556-1f47gvys 291 32 macrophages macrophage NNS cord-304556-1f47gvys 291 33 that that WDT cord-304556-1f47gvys 291 34 have have VBP cord-304556-1f47gvys 291 35 ingested ingest VBN cord-304556-1f47gvys 291 36 apoptotic apoptotic JJ cord-304556-1f47gvys 291 37 cells cell NNS cord-304556-1f47gvys 291 38 TNF tnf NN cord-304556-1f47gvys 291 39 - - HYPH cord-304556-1f47gvys 291 40 alpha alpha NN cord-304556-1f47gvys 291 41 , , , cord-304556-1f47gvys 291 42 IL-6 IL-6 NNP cord-304556-1f47gvys 291 43 , , , cord-304556-1f47gvys 291 44 and and CC cord-304556-1f47gvys 291 45 IL-1 IL-1 NNP cord-304556-1f47gvys 291 46 expression expression NN cord-304556-1f47gvys 291 47 is be VBZ cord-304556-1f47gvys 291 48 inhibited inhibit VBN cord-304556-1f47gvys 291 49 by by IN cord-304556-1f47gvys 291 50 GAS6 GAS6 NNP cord-304556-1f47gvys 291 51 in in IN cord-304556-1f47gvys 291 52 monocytes monocyte NNS cord-304556-1f47gvys 291 53 / / SYM cord-304556-1f47gvys 291 54 macrophages macrophage NNS cord-304556-1f47gvys 291 55 Macrophages macrophage NNS cord-304556-1f47gvys 291 56 that that WDT cord-304556-1f47gvys 291 57 have have VBP cord-304556-1f47gvys 291 58 ingested ingest VBN cord-304556-1f47gvys 291 59 apoptotic apoptotic JJ cord-304556-1f47gvys 291 60 cells cell NNS cord-304556-1f47gvys 291 61 in in IN cord-304556-1f47gvys 291 62 vitro vitro FW cord-304556-1f47gvys 291 63 inhibit inhibit VBP cord-304556-1f47gvys 291 64 proinflammatory proinflammatory JJ cord-304556-1f47gvys 291 65 cytokine cytokine NN cord-304556-1f47gvys 291 66 production production NN cord-304556-1f47gvys 291 67 through through IN cord-304556-1f47gvys 291 68 autocrine autocrine NN cord-304556-1f47gvys 291 69 / / SYM cord-304556-1f47gvys 291 70 paracrine paracrine NN cord-304556-1f47gvys 291 71 mechanisms mechanism NNS cord-304556-1f47gvys 291 72 involving involve VBG cord-304556-1f47gvys 291 73 TGF TGF NNP cord-304556-1f47gvys 291 74 - - HYPH cord-304556-1f47gvys 291 75 beta beta NN cord-304556-1f47gvys 291 76 , , , cord-304556-1f47gvys 291 77 PGE2 PGE2 NNP cord-304556-1f47gvys 291 78 , , , cord-304556-1f47gvys 291 79 and and CC cord-304556-1f47gvys 292 1 PAF PAF NNP cord-304556-1f47gvys 292 2 Thrombospondin Thrombospondin NNP cord-304556-1f47gvys 292 3 cooperates cooperate VBZ cord-304556-1f47gvys 292 4 with with IN cord-304556-1f47gvys 292 5 CD36 CD36 NNP cord-304556-1f47gvys 292 6 and and CC cord-304556-1f47gvys 293 1 the the DT cord-304556-1f47gvys 293 2 vitronectin vitronectin NNP cord-304556-1f47gvys 293 3 receptor receptor NN cord-304556-1f47gvys 293 4 in in IN cord-304556-1f47gvys 293 5 macrophage macrophage NN cord-304556-1f47gvys 293 6 recognition recognition NN cord-304556-1f47gvys 293 7 of of IN cord-304556-1f47gvys 293 8 neutrophils neutrophil NNS cord-304556-1f47gvys 293 9 undergoing undergo VBG cord-304556-1f47gvys 293 10 apoptosis apoptosis NN cord-304556-1f47gvys 294 1 Efferocytosis efferocytosis NN cord-304556-1f47gvys 294 2 impairs impair VBZ cord-304556-1f47gvys 294 3 pulmonary pulmonary JJ cord-304556-1f47gvys 294 4 macrophage macrophage NN cord-304556-1f47gvys 294 5 and and CC cord-304556-1f47gvys 294 6 lung lung NN cord-304556-1f47gvys 294 7 antibacterial antibacterial JJ cord-304556-1f47gvys 294 8 function function NN cord-304556-1f47gvys 294 9 via via IN cord-304556-1f47gvys 294 10 PGE2 PGE2 NNP cord-304556-1f47gvys 294 11 / / SYM cord-304556-1f47gvys 294 12 EP2 EP2 NNP cord-304556-1f47gvys 294 13 signaling signal VBG cord-304556-1f47gvys 294 14 Phosphatidylserinedependent Phosphatidylserinedependent NNP cord-304556-1f47gvys 294 15 ingestion ingestion NN cord-304556-1f47gvys 294 16 of of IN cord-304556-1f47gvys 294 17 apoptotic apoptotic JJ cord-304556-1f47gvys 294 18 cells cell NNS cord-304556-1f47gvys 294 19 promotes promote VBZ cord-304556-1f47gvys 294 20 TGF TGF NNP cord-304556-1f47gvys 294 21 - - HYPH cord-304556-1f47gvys 294 22 beta1 beta1 VBG cord-304556-1f47gvys 294 23 secretion secretion NN cord-304556-1f47gvys 294 24 and and CC cord-304556-1f47gvys 294 25 the the DT cord-304556-1f47gvys 294 26 resolution resolution NN cord-304556-1f47gvys 294 27 of of IN cord-304556-1f47gvys 294 28 inflammation inflammation NN cord-304556-1f47gvys 294 29 PPARgamma PPARgamma NNP cord-304556-1f47gvys 294 30 activation activation NN cord-304556-1f47gvys 294 31 following follow VBG cord-304556-1f47gvys 294 32 apoptotic apoptotic JJ cord-304556-1f47gvys 294 33 cell cell NN cord-304556-1f47gvys 294 34 instillation instillation NN cord-304556-1f47gvys 294 35 promotes promote VBZ cord-304556-1f47gvys 294 36 resolution resolution NN cord-304556-1f47gvys 294 37 of of IN cord-304556-1f47gvys 294 38 lung lung NN cord-304556-1f47gvys 294 39 inflammation inflammation NN cord-304556-1f47gvys 294 40 and and CC cord-304556-1f47gvys 294 41 fibrosis fibrosis NN cord-304556-1f47gvys 294 42 via via IN cord-304556-1f47gvys 294 43 regulation regulation NN cord-304556-1f47gvys 294 44 of of IN cord-304556-1f47gvys 294 45 efferocytosis efferocytosis NN cord-304556-1f47gvys 294 46 and and CC cord-304556-1f47gvys 294 47 proresolving proresolve VBG cord-304556-1f47gvys 294 48 cytokines cytokine NNS cord-304556-1f47gvys 295 1 Apoptotic apoptotic JJ cord-304556-1f47gvys 295 2 cells cell NNS cord-304556-1f47gvys 295 3 induce induce VBP cord-304556-1f47gvys 295 4 immunosuppression immunosuppression NN cord-304556-1f47gvys 295 5 through through IN cord-304556-1f47gvys 295 6 dendritic dendritic JJ cord-304556-1f47gvys 295 7 cells cell NNS cord-304556-1f47gvys 295 8 : : : cord-304556-1f47gvys 295 9 critical critical JJ cord-304556-1f47gvys 295 10 roles role NNS cord-304556-1f47gvys 295 11 of of IN cord-304556-1f47gvys 295 12 IFN IFN NNP cord-304556-1f47gvys 295 13 - - HYPH cord-304556-1f47gvys 295 14 gamma gamma NN cord-304556-1f47gvys 295 15 and and CC cord-304556-1f47gvys 295 16 nitric nitric NN cord-304556-1f47gvys 295 17 oxide oxide NN cord-304556-1f47gvys 296 1 CD103 CD103 NNP cord-304556-1f47gvys 296 2 + + CC cord-304556-1f47gvys 296 3 pulmonary pulmonary JJ cord-304556-1f47gvys 296 4 dendritic dendritic JJ cord-304556-1f47gvys 296 5 cells cell NNS cord-304556-1f47gvys 296 6 preferentially preferentially RB cord-304556-1f47gvys 296 7 acquire acquire VBP cord-304556-1f47gvys 296 8 and and CC cord-304556-1f47gvys 296 9 present present JJ cord-304556-1f47gvys 296 10 apoptotic apoptotic JJ cord-304556-1f47gvys 296 11 cell cell NN cord-304556-1f47gvys 296 12 - - HYPH cord-304556-1f47gvys 296 13 associated associate VBN cord-304556-1f47gvys 296 14 antigen antigen NN cord-304556-1f47gvys 296 15 Differential differential JJ cord-304556-1f47gvys 296 16 role role NN cord-304556-1f47gvys 296 17 of of IN cord-304556-1f47gvys 296 18 CD80 CD80 NNP cord-304556-1f47gvys 296 19 and and CC cord-304556-1f47gvys 296 20 CD86 CD86 NNP cord-304556-1f47gvys 296 21 on on IN cord-304556-1f47gvys 296 22 alveolar alveolar JJ cord-304556-1f47gvys 296 23 macrophages macrophage NNS cord-304556-1f47gvys 296 24 in in IN cord-304556-1f47gvys 296 25 the the DT cord-304556-1f47gvys 296 26 presentation presentation NN cord-304556-1f47gvys 296 27 of of IN cord-304556-1f47gvys 296 28 allergen allergen NN cord-304556-1f47gvys 296 29 to to IN cord-304556-1f47gvys 296 30 T T NNP cord-304556-1f47gvys 296 31 lymphocytes lymphocyte NNS cord-304556-1f47gvys 296 32 in in IN cord-304556-1f47gvys 296 33 asthma asthma NN cord-304556-1f47gvys 296 34 Alveolar Alveolar NNP cord-304556-1f47gvys 296 35 macrophages macrophage NNS cord-304556-1f47gvys 296 36 : : : cord-304556-1f47gvys 296 37 plasticity plasticity NN cord-304556-1f47gvys 296 38 in in IN cord-304556-1f47gvys 296 39 a a DT cord-304556-1f47gvys 296 40 tissue tissue NN cord-304556-1f47gvys 296 41 - - HYPH cord-304556-1f47gvys 296 42 specific specific JJ cord-304556-1f47gvys 296 43 context context NN cord-304556-1f47gvys 297 1 The the DT cord-304556-1f47gvys 297 2 prolonged prolonged JJ cord-304556-1f47gvys 297 3 life life NN cord-304556-1f47gvys 297 4 - - HYPH cord-304556-1f47gvys 297 5 span span NN cord-304556-1f47gvys 297 6 of of IN cord-304556-1f47gvys 297 7 alveolar alveolar NN cord-304556-1f47gvys 297 8 macrophages macrophage NNS cord-304556-1f47gvys 297 9 Fas Fas NNP cord-304556-1f47gvys 297 10 determines determine VBZ cord-304556-1f47gvys 297 11 differential differential JJ cord-304556-1f47gvys 297 12 fates fate NNS cord-304556-1f47gvys 297 13 of of IN cord-304556-1f47gvys 297 14 resident resident NN cord-304556-1f47gvys 297 15 and and CC cord-304556-1f47gvys 297 16 recruited recruit VBD cord-304556-1f47gvys 297 17 macrophages macrophage NNS cord-304556-1f47gvys 297 18 during during IN cord-304556-1f47gvys 297 19 resolution resolution NN cord-304556-1f47gvys 297 20 of of IN cord-304556-1f47gvys 297 21 acute acute JJ cord-304556-1f47gvys 297 22 lung lung NN cord-304556-1f47gvys 297 23 injury injury NN cord-304556-1f47gvys 297 24 Depletion depletion NN cord-304556-1f47gvys 297 25 of of IN cord-304556-1f47gvys 297 26 alveolar alveolar JJ cord-304556-1f47gvys 297 27 macrophages macrophage NNS cord-304556-1f47gvys 297 28 during during IN cord-304556-1f47gvys 297 29 influenza influenza NN cord-304556-1f47gvys 297 30 infection infection NN cord-304556-1f47gvys 297 31 facilitates facilitate VBZ cord-304556-1f47gvys 297 32 bacterial bacterial JJ cord-304556-1f47gvys 297 33 superinfections superinfection NNS cord-304556-1f47gvys 298 1 A a DT cord-304556-1f47gvys 298 2 lineage lineage NN cord-304556-1f47gvys 298 3 of of IN cord-304556-1f47gvys 298 4 myeloid myeloid NN cord-304556-1f47gvys 298 5 cells cell NNS cord-304556-1f47gvys 298 6 independent independent JJ cord-304556-1f47gvys 298 7 of of IN cord-304556-1f47gvys 298 8 Myb Myb NNP cord-304556-1f47gvys 298 9 and and CC cord-304556-1f47gvys 298 10 hematopoietic hematopoietic JJ cord-304556-1f47gvys 298 11 stem stem NN cord-304556-1f47gvys 298 12 cells cell NNS cord-304556-1f47gvys 299 1 Ciliated ciliated JJ cord-304556-1f47gvys 299 2 epithelial epithelial JJ cord-304556-1f47gvys 299 3 cell cell NN cord-304556-1f47gvys 299 4 lifespan lifespan NN cord-304556-1f47gvys 299 5 in in IN cord-304556-1f47gvys 299 6 the the DT cord-304556-1f47gvys 299 7 mouse mouse NN cord-304556-1f47gvys 299 8 trachea trachea NN cord-304556-1f47gvys 299 9 and and CC cord-304556-1f47gvys 299 10 lung lung NN cord-304556-1f47gvys 299 11 Apoptotic apoptotic JJ cord-304556-1f47gvys 299 12 cell cell NN cord-304556-1f47gvys 299 13 clearance clearance NN cord-304556-1f47gvys 299 14 by by IN cord-304556-1f47gvys 299 15 bronchial bronchial JJ cord-304556-1f47gvys 299 16 epithelial epithelial JJ cord-304556-1f47gvys 299 17 cells cell NNS cord-304556-1f47gvys 299 18 critically critically RB cord-304556-1f47gvys 299 19 influences influence VBZ cord-304556-1f47gvys 299 20 airway airway NN cord-304556-1f47gvys 299 21 inflammation inflammation NN cord-304556-1f47gvys 299 22 Endothelial endothelial JJ cord-304556-1f47gvys 299 23 cell cell NN cord-304556-1f47gvys 299 24 death death NN cord-304556-1f47gvys 299 25 and and CC cord-304556-1f47gvys 299 26 decreased decrease VBD cord-304556-1f47gvys 299 27 expression expression NN cord-304556-1f47gvys 299 28 of of IN cord-304556-1f47gvys 299 29 vascular vascular JJ cord-304556-1f47gvys 299 30 endothelial endothelial JJ cord-304556-1f47gvys 299 31 growth growth NN cord-304556-1f47gvys 299 32 factor factor NN cord-304556-1f47gvys 299 33 and and CC cord-304556-1f47gvys 299 34 vascular vascular JJ cord-304556-1f47gvys 299 35 endothelial endothelial JJ cord-304556-1f47gvys 299 36 growth growth NN cord-304556-1f47gvys 299 37 factor factor NN cord-304556-1f47gvys 299 38 receptor receptor NN cord-304556-1f47gvys 299 39 2 2 CD cord-304556-1f47gvys 299 40 in in IN cord-304556-1f47gvys 299 41 emphysema emphysema NN cord-304556-1f47gvys 300 1 Alveolar alveolar NN cord-304556-1f47gvys 300 2 macrophages macrophage NNS cord-304556-1f47gvys 300 3 have have VBP cord-304556-1f47gvys 300 4 a a DT cord-304556-1f47gvys 300 5 protective protective JJ cord-304556-1f47gvys 300 6 antiinflammatory antiinflammatory JJ cord-304556-1f47gvys 300 7 role role NN cord-304556-1f47gvys 300 8 during during IN cord-304556-1f47gvys 300 9 murine murine JJ cord-304556-1f47gvys 300 10 pneumococcal pneumococcal JJ cord-304556-1f47gvys 300 11 pneumonia pneumonia NN cord-304556-1f47gvys 300 12 Role role NN cord-304556-1f47gvys 300 13 of of IN cord-304556-1f47gvys 300 14 apoptosis apoptosis NN cord-304556-1f47gvys 300 15 in in IN cord-304556-1f47gvys 300 16 amplifying amplify VBG cord-304556-1f47gvys 300 17 inflammatory inflammatory JJ cord-304556-1f47gvys 300 18 responses response NNS cord-304556-1f47gvys 300 19 in in IN cord-304556-1f47gvys 300 20 lung lung NN cord-304556-1f47gvys 300 21 diseases disease NNS cord-304556-1f47gvys 300 22 Impairment Impairment NNP cord-304556-1f47gvys 300 23 of of IN cord-304556-1f47gvys 300 24 phagocytosis phagocytosis NN cord-304556-1f47gvys 300 25 of of IN cord-304556-1f47gvys 300 26 apoptotic apoptotic JJ cord-304556-1f47gvys 300 27 cells cell NNS cord-304556-1f47gvys 300 28 and and CC cord-304556-1f47gvys 300 29 its -PRON- PRP$ cord-304556-1f47gvys 300 30 role role NN cord-304556-1f47gvys 300 31 in in IN cord-304556-1f47gvys 300 32 chronic chronic JJ cord-304556-1f47gvys 300 33 airway airway NN cord-304556-1f47gvys 300 34 diseases disease NNS cord-304556-1f47gvys 301 1 Efferocytosis efferocytosis NN cord-304556-1f47gvys 301 2 and and CC cord-304556-1f47gvys 301 3 lung lung NN cord-304556-1f47gvys 301 4 disease disease NN cord-304556-1f47gvys 301 5 Immunology Immunology NNP cord-304556-1f47gvys 301 6 of of IN cord-304556-1f47gvys 301 7 asthma asthma NN cord-304556-1f47gvys 301 8 and and CC cord-304556-1f47gvys 301 9 chronic chronic JJ cord-304556-1f47gvys 301 10 obstructive obstructive JJ cord-304556-1f47gvys 301 11 pulmonary pulmonary JJ cord-304556-1f47gvys 301 12 disease disease NN cord-304556-1f47gvys 301 13 Role role NN cord-304556-1f47gvys 301 14 of of IN cord-304556-1f47gvys 301 15 apoptosis apoptosis NN cord-304556-1f47gvys 301 16 in in IN cord-304556-1f47gvys 301 17 the the DT cord-304556-1f47gvys 301 18 pathogenesis pathogenesis NN cord-304556-1f47gvys 301 19 of of IN cord-304556-1f47gvys 301 20 COPD COPD NNP cord-304556-1f47gvys 301 21 and and CC cord-304556-1f47gvys 301 22 pulmonary pulmonary JJ cord-304556-1f47gvys 301 23 emphysema emphysema NN cord-304556-1f47gvys 301 24 Correlation correlation NN cord-304556-1f47gvys 301 25 of of IN cord-304556-1f47gvys 301 26 lung lung NN cord-304556-1f47gvys 301 27 surface surface NN cord-304556-1f47gvys 301 28 area area NN cord-304556-1f47gvys 302 1 to to IN cord-304556-1f47gvys 302 2 apoptosis apoptosis NN cord-304556-1f47gvys 302 3 and and CC cord-304556-1f47gvys 302 4 proliferation proliferation NN cord-304556-1f47gvys 302 5 in in IN cord-304556-1f47gvys 302 6 human human JJ cord-304556-1f47gvys 302 7 emphysema emphysema NN cord-304556-1f47gvys 303 1 Increased increase VBN cord-304556-1f47gvys 303 2 apoptosis apoptosis NN cord-304556-1f47gvys 303 3 of of IN cord-304556-1f47gvys 303 4 neutrophils neutrophil NNS cord-304556-1f47gvys 303 5 in in IN cord-304556-1f47gvys 303 6 induced induce VBN cord-304556-1f47gvys 303 7 sputum sputum NN cord-304556-1f47gvys 303 8 of of IN cord-304556-1f47gvys 303 9 COPD COPD NNP cord-304556-1f47gvys 303 10 patients patient NNS cord-304556-1f47gvys 304 1 Alveolar alveolar JJ cord-304556-1f47gvys 304 2 wall wall NN cord-304556-1f47gvys 304 3 apoptosis apoptosis NN cord-304556-1f47gvys 304 4 causes cause VBZ cord-304556-1f47gvys 304 5 lung lung NN cord-304556-1f47gvys 304 6 destruction destruction NN cord-304556-1f47gvys 304 7 and and CC cord-304556-1f47gvys 304 8 emphysematous emphysematous JJ cord-304556-1f47gvys 304 9 changes change NNS cord-304556-1f47gvys 305 1 Alveolar alveolar NN cord-304556-1f47gvys 305 2 macrophages macrophage NNS cord-304556-1f47gvys 305 3 from from IN cord-304556-1f47gvys 305 4 subjects subject NNS cord-304556-1f47gvys 305 5 with with IN cord-304556-1f47gvys 305 6 chronic chronic JJ cord-304556-1f47gvys 305 7 obstructive obstructive JJ cord-304556-1f47gvys 305 8 pulmonary pulmonary JJ cord-304556-1f47gvys 305 9 disease disease NN cord-304556-1f47gvys 305 10 are be VBP cord-304556-1f47gvys 305 11 deficient deficient JJ cord-304556-1f47gvys 305 12 in in IN cord-304556-1f47gvys 305 13 their -PRON- PRP$ cord-304556-1f47gvys 305 14 ability ability NN cord-304556-1f47gvys 305 15 to to TO cord-304556-1f47gvys 305 16 phagocytose phagocytose VB cord-304556-1f47gvys 305 17 apoptotic apoptotic JJ cord-304556-1f47gvys 305 18 airway airway NN cord-304556-1f47gvys 305 19 epithelial epithelial NN cord-304556-1f47gvys 305 20 cells cell NNS cord-304556-1f47gvys 305 21 Animal animal NN cord-304556-1f47gvys 305 22 models model NNS cord-304556-1f47gvys 305 23 of of IN cord-304556-1f47gvys 305 24 chronic chronic JJ cord-304556-1f47gvys 305 25 obstructive obstructive JJ cord-304556-1f47gvys 305 26 pulmonary pulmonary JJ cord-304556-1f47gvys 305 27 disease disease NN cord-304556-1f47gvys 305 28 Cigarette Cigarette NNP cord-304556-1f47gvys 305 29 smoke smoke NN cord-304556-1f47gvys 305 30 - - HYPH cord-304556-1f47gvys 305 31 induced induce VBN cord-304556-1f47gvys 305 32 changes change NNS cord-304556-1f47gvys 305 33 to to IN cord-304556-1f47gvys 305 34 alveolar alveolar JJ cord-304556-1f47gvys 305 35 macrophage macrophage NN cord-304556-1f47gvys 305 36 phenotype phenotype NN cord-304556-1f47gvys 305 37 and and CC cord-304556-1f47gvys 305 38 function function NN cord-304556-1f47gvys 305 39 are be VBP cord-304556-1f47gvys 305 40 improved improve VBN cord-304556-1f47gvys 305 41 by by IN cord-304556-1f47gvys 305 42 treatment treatment NN cord-304556-1f47gvys 305 43 with with IN cord-304556-1f47gvys 305 44 procysteine procysteine NNP cord-304556-1f47gvys 305 45 Cigarette Cigarette NNP cord-304556-1f47gvys 305 46 smoke smoke NN cord-304556-1f47gvys 305 47 impairs impair VBZ cord-304556-1f47gvys 305 48 clearance clearance NN cord-304556-1f47gvys 305 49 of of IN cord-304556-1f47gvys 305 50 apoptotic apoptotic JJ cord-304556-1f47gvys 305 51 cells cell NNS cord-304556-1f47gvys 305 52 through through IN cord-304556-1f47gvys 305 53 oxidant oxidant JJ cord-304556-1f47gvys 305 54 - - HYPH cord-304556-1f47gvys 305 55 dependent dependent JJ cord-304556-1f47gvys 305 56 activation activation NN cord-304556-1f47gvys 305 57 of of IN cord-304556-1f47gvys 305 58 RhoA RhoA NNP cord-304556-1f47gvys 305 59 High high JJ cord-304556-1f47gvys 305 60 mobility mobility NN cord-304556-1f47gvys 305 61 group group NN cord-304556-1f47gvys 305 62 protein-1 protein-1 NNP cord-304556-1f47gvys 305 63 inhibits inhibit VBZ cord-304556-1f47gvys 305 64 phagocytosis phagocytosis NN cord-304556-1f47gvys 305 65 of of IN cord-304556-1f47gvys 305 66 apoptotic apoptotic JJ cord-304556-1f47gvys 305 67 neutrophils neutrophil NNS cord-304556-1f47gvys 305 68 through through IN cord-304556-1f47gvys 305 69 binding bind VBG cord-304556-1f47gvys 305 70 to to IN cord-304556-1f47gvys 305 71 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 305 72 HMGB1 HMGB1 NNP cord-304556-1f47gvys 305 73 inhibits inhibit VBZ cord-304556-1f47gvys 305 74 macrophage macrophage NN cord-304556-1f47gvys 305 75 activity activity NN cord-304556-1f47gvys 305 76 in in IN cord-304556-1f47gvys 305 77 efferocytosis efferocytosis NN cord-304556-1f47gvys 305 78 through through IN cord-304556-1f47gvys 305 79 binding bind VBG cord-304556-1f47gvys 305 80 to to IN cord-304556-1f47gvys 305 81 the the DT cord-304556-1f47gvys 305 82 alphavbeta3-integrin alphavbeta3-integrin JJ cord-304556-1f47gvys 305 83 High high JJ cord-304556-1f47gvys 305 84 mobility mobility NN cord-304556-1f47gvys 305 85 group group NN cord-304556-1f47gvys 305 86 protein protein NN cord-304556-1f47gvys 305 87 B1 b1 NN cord-304556-1f47gvys 305 88 ( ( -LRB- cord-304556-1f47gvys 305 89 HMGB1 HMGB1 NNP cord-304556-1f47gvys 305 90 ) ) -RRB- cord-304556-1f47gvys 305 91 in in IN cord-304556-1f47gvys 305 92 asthma asthma NN cord-304556-1f47gvys 305 93 : : : cord-304556-1f47gvys 305 94 comparison comparison NN cord-304556-1f47gvys 305 95 of of IN cord-304556-1f47gvys 305 96 patients patient NNS cord-304556-1f47gvys 305 97 with with IN cord-304556-1f47gvys 305 98 chronic chronic JJ cord-304556-1f47gvys 305 99 obstructive obstructive JJ cord-304556-1f47gvys 305 100 pulmonary pulmonary JJ cord-304556-1f47gvys 305 101 disease disease NN cord-304556-1f47gvys 305 102 and and CC cord-304556-1f47gvys 305 103 healthy healthy JJ cord-304556-1f47gvys 305 104 controls control NNS cord-304556-1f47gvys 305 105 C1q C1q NNP cord-304556-1f47gvys 305 106 and and CC cord-304556-1f47gvys 305 107 mannose mannose NN cord-304556-1f47gvys 305 108 binding bind VBG cord-304556-1f47gvys 305 109 lectin lectin NN cord-304556-1f47gvys 305 110 engagement engagement NN cord-304556-1f47gvys 305 111 of of IN cord-304556-1f47gvys 305 112 cell cell NN cord-304556-1f47gvys 305 113 surface surface NN cord-304556-1f47gvys 305 114 calreticulin calreticulin NNP cord-304556-1f47gvys 305 115 and and CC cord-304556-1f47gvys 305 116 CD91 CD91 NNP cord-304556-1f47gvys 305 117 initiates initiate VBZ cord-304556-1f47gvys 305 118 macropinocytosis macropinocytosis NNP cord-304556-1f47gvys 305 119 and and CC cord-304556-1f47gvys 305 120 uptake uptake NN cord-304556-1f47gvys 305 121 of of IN cord-304556-1f47gvys 305 122 apoptotic apoptotic JJ cord-304556-1f47gvys 305 123 cells cell NNS cord-304556-1f47gvys 305 124 Therapeutic therapeutic JJ cord-304556-1f47gvys 305 125 role role NN cord-304556-1f47gvys 305 126 for for IN cord-304556-1f47gvys 305 127 mannose mannose NN cord-304556-1f47gvys 305 128 - - HYPH cord-304556-1f47gvys 305 129 binding bind VBG cord-304556-1f47gvys 305 130 lectin lectin NN cord-304556-1f47gvys 305 131 in in IN cord-304556-1f47gvys 305 132 cigarette cigarette NN cord-304556-1f47gvys 305 133 smoke smoke NN cord-304556-1f47gvys 305 134 - - HYPH cord-304556-1f47gvys 305 135 induced induce VBN cord-304556-1f47gvys 305 136 lung lung NN cord-304556-1f47gvys 305 137 inflammation inflammation NN cord-304556-1f47gvys 305 138 ? ? . cord-304556-1f47gvys 306 1 Evidence evidence NN cord-304556-1f47gvys 306 2 from from IN cord-304556-1f47gvys 306 3 a a DT cord-304556-1f47gvys 306 4 murine murine JJ cord-304556-1f47gvys 306 5 model model NN cord-304556-1f47gvys 307 1 Oxidative oxidative JJ cord-304556-1f47gvys 307 2 stress stress NN cord-304556-1f47gvys 307 3 decreases decrease VBZ cord-304556-1f47gvys 308 1 functional functional JJ cord-304556-1f47gvys 308 2 airway airway NN cord-304556-1f47gvys 308 3 mannose mannose NN cord-304556-1f47gvys 308 4 binding bind VBG cord-304556-1f47gvys 308 5 lectin lectin NN cord-304556-1f47gvys 308 6 in in IN cord-304556-1f47gvys 308 7 COPD COPD NNP cord-304556-1f47gvys 308 8 Surfactant Surfactant NNP cord-304556-1f47gvys 308 9 proteins protein NNS cord-304556-1f47gvys 309 1 A a NN cord-304556-1f47gvys 309 2 and and CC cord-304556-1f47gvys 309 3 D d JJ cord-304556-1f47gvys 309 4 suppress suppress VBP cord-304556-1f47gvys 309 5 alveolar alveolar NN cord-304556-1f47gvys 309 6 macrophage macrophage NN cord-304556-1f47gvys 309 7 phagocytosis phagocytosis NN cord-304556-1f47gvys 309 8 via via IN cord-304556-1f47gvys 309 9 interaction interaction NN cord-304556-1f47gvys 309 10 with with IN cord-304556-1f47gvys 310 1 SIRP SIRP NNP cord-304556-1f47gvys 310 2 alpha alpha NN cord-304556-1f47gvys 310 3 Surfactant Surfactant NNP cord-304556-1f47gvys 310 4 protein protein NN cord-304556-1f47gvys 310 5 A A NNP cord-304556-1f47gvys 310 6 enhances enhance VBZ cord-304556-1f47gvys 310 7 alveolar alveolar NN cord-304556-1f47gvys 310 8 macrophage macrophage NN cord-304556-1f47gvys 310 9 phagocytosis phagocytosis NN cord-304556-1f47gvys 310 10 of of IN cord-304556-1f47gvys 310 11 apoptotic apoptotic JJ cord-304556-1f47gvys 310 12 neutrophils neutrophil NNS cord-304556-1f47gvys 310 13 Chronic Chronic NNP cord-304556-1f47gvys 310 14 obstructive obstructive JJ cord-304556-1f47gvys 310 15 pulmonary pulmonary JJ cord-304556-1f47gvys 310 16 disease disease NN cord-304556-1f47gvys 310 17 and and CC cord-304556-1f47gvys 310 18 inhaled inhale VBN cord-304556-1f47gvys 310 19 steroids steroid NNS cord-304556-1f47gvys 310 20 alter alter VBP cord-304556-1f47gvys 310 21 surfactant surfactant NN cord-304556-1f47gvys 310 22 protein protein NN cord-304556-1f47gvys 310 23 D D NNP cord-304556-1f47gvys 310 24 ( ( -LRB- cord-304556-1f47gvys 310 25 SP SP NNP cord-304556-1f47gvys 310 26 - - HYPH cord-304556-1f47gvys 310 27 D D NNP cord-304556-1f47gvys 310 28 ) ) -RRB- cord-304556-1f47gvys 310 29 levels level NNS cord-304556-1f47gvys 310 30 : : : cord-304556-1f47gvys 310 31 a a DT cord-304556-1f47gvys 310 32 cross cross JJ cord-304556-1f47gvys 310 33 - - JJ cord-304556-1f47gvys 310 34 sectional sectional JJ cord-304556-1f47gvys 310 35 study study NN cord-304556-1f47gvys 310 36 The the DT cord-304556-1f47gvys 310 37 immunology immunology NN cord-304556-1f47gvys 310 38 of of IN cord-304556-1f47gvys 310 39 asthma asthma NN cord-304556-1f47gvys 311 1 Asthmatic asthmatic JJ cord-304556-1f47gvys 311 2 bronchial bronchial JJ cord-304556-1f47gvys 311 3 epithelium epithelium NN cord-304556-1f47gvys 311 4 is be VBZ cord-304556-1f47gvys 311 5 more more RBR cord-304556-1f47gvys 311 6 susceptible susceptible JJ cord-304556-1f47gvys 311 7 to to IN cord-304556-1f47gvys 311 8 oxidant oxidant JJ cord-304556-1f47gvys 311 9 - - HYPH cord-304556-1f47gvys 311 10 induced induce VBN cord-304556-1f47gvys 311 11 apoptosis apoptosis NN cord-304556-1f47gvys 311 12 Human human JJ cord-304556-1f47gvys 311 13 alveolar alveolar NN cord-304556-1f47gvys 311 14 epithelial epithelial JJ cord-304556-1f47gvys 311 15 cells cell NNS cord-304556-1f47gvys 311 16 engulf engulf VBP cord-304556-1f47gvys 311 17 apoptotic apoptotic JJ cord-304556-1f47gvys 311 18 eosinophils eosinophil NNS cord-304556-1f47gvys 311 19 by by IN cord-304556-1f47gvys 311 20 means mean NNS cord-304556-1f47gvys 311 21 of of IN cord-304556-1f47gvys 311 22 integrin integrin NN cord-304556-1f47gvys 311 23 - - HYPH cord-304556-1f47gvys 311 24 and and CC cord-304556-1f47gvys 311 25 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 311 26 receptor receptor NN cord-304556-1f47gvys 311 27 - - HYPH cord-304556-1f47gvys 311 28 dependent dependent JJ cord-304556-1f47gvys 311 29 mechanisms mechanism NNS cord-304556-1f47gvys 311 30 : : : cord-304556-1f47gvys 311 31 a a DT cord-304556-1f47gvys 311 32 process process NN cord-304556-1f47gvys 311 33 upregulated upregulate VBN cord-304556-1f47gvys 311 34 by by IN cord-304556-1f47gvys 311 35 dexamethasone dexamethasone JJ cord-304556-1f47gvys 311 36 Eosinophil eosinophil JJ cord-304556-1f47gvys 311 37 apoptosis apoptosis NN cord-304556-1f47gvys 311 38 and and CC cord-304556-1f47gvys 311 39 the the DT cord-304556-1f47gvys 311 40 resolution resolution NN cord-304556-1f47gvys 311 41 of of IN cord-304556-1f47gvys 311 42 airway airway JJ cord-304556-1f47gvys 311 43 inflammation inflammation NN cord-304556-1f47gvys 311 44 in in IN cord-304556-1f47gvys 311 45 asthma asthma NN cord-304556-1f47gvys 311 46 Eosinophils Eosinophils NNP cord-304556-1f47gvys 311 47 in in IN cord-304556-1f47gvys 311 48 the the DT cord-304556-1f47gvys 311 49 lung lung NN cord-304556-1f47gvys 311 50 - - HYPH cord-304556-1f47gvys 311 51 modulating modulate VBG cord-304556-1f47gvys 311 52 apoptosis apoptosis NN cord-304556-1f47gvys 311 53 and and CC cord-304556-1f47gvys 311 54 efferocytosis efferocytosis NN cord-304556-1f47gvys 311 55 in in IN cord-304556-1f47gvys 312 1 airway airway NN cord-304556-1f47gvys 312 2 inflammation inflammation NN cord-304556-1f47gvys 312 3 Defective defective JJ cord-304556-1f47gvys 312 4 apoptotic apoptotic JJ cord-304556-1f47gvys 312 5 cell cell NN cord-304556-1f47gvys 312 6 phagocytosis phagocytosis NN cord-304556-1f47gvys 312 7 attenuates attenuate VBZ cord-304556-1f47gvys 312 8 prostaglandin prostaglandin NN cord-304556-1f47gvys 312 9 E2 e2 NN cord-304556-1f47gvys 312 10 and and CC cord-304556-1f47gvys 312 11 15-hydroxyeicosatetraenoic 15-hydroxyeicosatetraenoic CD cord-304556-1f47gvys 312 12 acid acid NN cord-304556-1f47gvys 312 13 in in IN cord-304556-1f47gvys 312 14 severe severe JJ cord-304556-1f47gvys 312 15 asthma asthma NN cord-304556-1f47gvys 312 16 alveolar alveolar NN cord-304556-1f47gvys 312 17 macrophages macrophage NNS cord-304556-1f47gvys 313 1 Impaired impaired JJ cord-304556-1f47gvys 313 2 macrophage macrophage NN cord-304556-1f47gvys 313 3 phagocytosis phagocytosis NN cord-304556-1f47gvys 313 4 in in IN cord-304556-1f47gvys 313 5 noneosinophilic noneosinophilic NNP cord-304556-1f47gvys 313 6 asthma asthma NNP cord-304556-1f47gvys 314 1 Innate innate JJ cord-304556-1f47gvys 314 2 immune immune JJ cord-304556-1f47gvys 314 3 activation activation NN cord-304556-1f47gvys 314 4 in in IN cord-304556-1f47gvys 314 5 neutrophilic neutrophilic NNP cord-304556-1f47gvys 314 6 asthma asthma NN cord-304556-1f47gvys 314 7 and and CC cord-304556-1f47gvys 314 8 bronchiectasis bronchiectasis NN cord-304556-1f47gvys 314 9 Obesity obesity NN cord-304556-1f47gvys 314 10 and and CC cord-304556-1f47gvys 314 11 asthma asthma NN cord-304556-1f47gvys 314 12 : : : cord-304556-1f47gvys 315 1 impact impact NN cord-304556-1f47gvys 315 2 on on IN cord-304556-1f47gvys 315 3 severity severity NN cord-304556-1f47gvys 315 4 , , , cord-304556-1f47gvys 315 5 asthma asthma NN cord-304556-1f47gvys 315 6 control control NN cord-304556-1f47gvys 315 7 , , , cord-304556-1f47gvys 315 8 and and CC cord-304556-1f47gvys 315 9 response response NN cord-304556-1f47gvys 315 10 to to IN cord-304556-1f47gvys 315 11 therapy therapy NN cord-304556-1f47gvys 315 12 Obesity obesity NN cord-304556-1f47gvys 315 13 impairs impair VBZ cord-304556-1f47gvys 315 14 apoptotic apoptotic JJ cord-304556-1f47gvys 315 15 cell cell NN cord-304556-1f47gvys 315 16 clearance clearance NN cord-304556-1f47gvys 315 17 in in IN cord-304556-1f47gvys 315 18 asthma asthma NN cord-304556-1f47gvys 315 19 TIM-1 TIM-1 NNP cord-304556-1f47gvys 315 20 , , , cord-304556-1f47gvys 315 21 a a DT cord-304556-1f47gvys 315 22 novel novel JJ cord-304556-1f47gvys 315 23 allergy allergy NN cord-304556-1f47gvys 315 24 and and CC cord-304556-1f47gvys 315 25 asthma asthma NN cord-304556-1f47gvys 315 26 susceptibility susceptibility NN cord-304556-1f47gvys 315 27 gene gene NN cord-304556-1f47gvys 315 28 TIM TIM NNP cord-304556-1f47gvys 315 29 genes gene NNS cord-304556-1f47gvys 315 30 : : : cord-304556-1f47gvys 315 31 a a DT cord-304556-1f47gvys 315 32 family family NN cord-304556-1f47gvys 315 33 of of IN cord-304556-1f47gvys 315 34 cell cell NN cord-304556-1f47gvys 315 35 surface surface NN cord-304556-1f47gvys 315 36 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 315 37 receptors receptor NNS cord-304556-1f47gvys 315 38 that that WDT cord-304556-1f47gvys 315 39 regulate regulate VBP cord-304556-1f47gvys 315 40 innate innate JJ cord-304556-1f47gvys 315 41 and and CC cord-304556-1f47gvys 315 42 adaptive adaptive JJ cord-304556-1f47gvys 315 43 immunity immunity NN cord-304556-1f47gvys 315 44 Apoptotic Apoptotic NNP cord-304556-1f47gvys 315 45 cells cell NNS cord-304556-1f47gvys 315 46 activate activate VBP cord-304556-1f47gvys 315 47 NKT NKT NNP cord-304556-1f47gvys 315 48 cells cell NNS cord-304556-1f47gvys 315 49 through through IN cord-304556-1f47gvys 315 50 T t NN cord-304556-1f47gvys 315 51 cell cell NN cord-304556-1f47gvys 315 52 Ig Ig NNP cord-304556-1f47gvys 315 53 - - HYPH cord-304556-1f47gvys 315 54 like like JJ cord-304556-1f47gvys 315 55 mucin mucin NN cord-304556-1f47gvys 315 56 - - : cord-304556-1f47gvys 315 57 like-1 like-1 NN cord-304556-1f47gvys 315 58 resulting result VBG cord-304556-1f47gvys 315 59 in in IN cord-304556-1f47gvys 315 60 airway airway NN cord-304556-1f47gvys 315 61 hyperreactivity hyperreactivity NNP cord-304556-1f47gvys 315 62 Alveolar Alveolar NNP cord-304556-1f47gvys 315 63 macrophage macrophage NN cord-304556-1f47gvys 315 64 phagocytosis phagocytosis NN cord-304556-1f47gvys 315 65 is be VBZ cord-304556-1f47gvys 315 66 impaired impair VBN cord-304556-1f47gvys 315 67 in in IN cord-304556-1f47gvys 315 68 children child NNS cord-304556-1f47gvys 315 69 with with IN cord-304556-1f47gvys 315 70 poorly poorly RB cord-304556-1f47gvys 315 71 controlled control VBN cord-304556-1f47gvys 315 72 asthma asthma NN cord-304556-1f47gvys 315 73 Phagocytosis Phagocytosis NNP cord-304556-1f47gvys 315 74 of of IN cord-304556-1f47gvys 315 75 apoptotic apoptotic JJ cord-304556-1f47gvys 315 76 eosinophils eosinophil NNS cord-304556-1f47gvys 315 77 but but CC cord-304556-1f47gvys 315 78 not not RB cord-304556-1f47gvys 315 79 neutrophils neutrophil NNS cord-304556-1f47gvys 315 80 by by IN cord-304556-1f47gvys 315 81 bronchial bronchial JJ cord-304556-1f47gvys 315 82 epithelial epithelial JJ cord-304556-1f47gvys 315 83 cells cell NNS cord-304556-1f47gvys 316 1 Airway airway JJ cord-304556-1f47gvys 316 2 inflammation inflammation NN cord-304556-1f47gvys 316 3 in in IN cord-304556-1f47gvys 316 4 cystic cystic JJ cord-304556-1f47gvys 316 5 fibrosis fibrosis NN cord-304556-1f47gvys 316 6 : : : cord-304556-1f47gvys 317 1 molecular molecular JJ cord-304556-1f47gvys 317 2 mechanisms mechanism NNS cord-304556-1f47gvys 317 3 and and CC cord-304556-1f47gvys 317 4 clinical clinical JJ cord-304556-1f47gvys 317 5 implications implication NNS cord-304556-1f47gvys 318 1 Potential potential JJ cord-304556-1f47gvys 318 2 role role NN cord-304556-1f47gvys 318 3 of of IN cord-304556-1f47gvys 318 4 high high JJ cord-304556-1f47gvys 318 5 - - HYPH cord-304556-1f47gvys 318 6 mobility mobility NN cord-304556-1f47gvys 318 7 group group NN cord-304556-1f47gvys 318 8 box box NN cord-304556-1f47gvys 318 9 1 1 CD cord-304556-1f47gvys 318 10 in in IN cord-304556-1f47gvys 318 11 cystic cystic JJ cord-304556-1f47gvys 318 12 fibrosis fibrosis NN cord-304556-1f47gvys 318 13 airway airway NN cord-304556-1f47gvys 318 14 disease disease NN cord-304556-1f47gvys 318 15 Impairment Impairment NNP cord-304556-1f47gvys 318 16 of of IN cord-304556-1f47gvys 318 17 apoptotic apoptotic JJ cord-304556-1f47gvys 318 18 cell cell NN cord-304556-1f47gvys 318 19 engulfment engulfment NN cord-304556-1f47gvys 318 20 by by IN cord-304556-1f47gvys 318 21 pyocyanin pyocyanin NNP cord-304556-1f47gvys 318 22 , , , cord-304556-1f47gvys 318 23 a a DT cord-304556-1f47gvys 318 24 toxic toxic JJ cord-304556-1f47gvys 318 25 metabolite metabolite NN cord-304556-1f47gvys 318 26 of of IN cord-304556-1f47gvys 318 27 Pseudomonas Pseudomonas NNP cord-304556-1f47gvys 318 28 aeruginosa aeruginosa NNP cord-304556-1f47gvys 318 29 Impact Impact NNP cord-304556-1f47gvys 318 30 of of IN cord-304556-1f47gvys 318 31 alginate alginate NN cord-304556-1f47gvys 318 32 Dysfunctional dysfunctional JJ cord-304556-1f47gvys 318 33 cystic cystic JJ cord-304556-1f47gvys 318 34 fibrosis fibrosis NN cord-304556-1f47gvys 318 35 transmembrane transmembrane NNP cord-304556-1f47gvys 318 36 conductance conductance NN cord-304556-1f47gvys 318 37 regulator regulator NN cord-304556-1f47gvys 318 38 inhibits inhibit VBZ cord-304556-1f47gvys 318 39 phagocytosis phagocytosis NN cord-304556-1f47gvys 318 40 of of IN cord-304556-1f47gvys 318 41 apoptotic apoptotic JJ cord-304556-1f47gvys 318 42 cells cell NNS cord-304556-1f47gvys 318 43 with with IN cord-304556-1f47gvys 318 44 proinflammatory proinflammatory JJ cord-304556-1f47gvys 318 45 consequences consequence NNS cord-304556-1f47gvys 319 1 Defective defective JJ cord-304556-1f47gvys 319 2 efferocytosis efferocytosis NN cord-304556-1f47gvys 319 3 by by IN cord-304556-1f47gvys 319 4 alveolar alveolar JJ cord-304556-1f47gvys 319 5 macrophages macrophage NNS cord-304556-1f47gvys 319 6 in in IN cord-304556-1f47gvys 319 7 IPF IPF NNP cord-304556-1f47gvys 319 8 patients patient NNS cord-304556-1f47gvys 319 9 Idiopathic idiopathic JJ cord-304556-1f47gvys 319 10 pulmonary pulmonary JJ cord-304556-1f47gvys 319 11 fibrosis fibrosis NN cord-304556-1f47gvys 319 12 : : : cord-304556-1f47gvys 320 1 evolving evolve VBG cord-304556-1f47gvys 320 2 concepts concept NNS cord-304556-1f47gvys 320 3 Apoptotic apoptotic JJ cord-304556-1f47gvys 320 4 cell cell NN cord-304556-1f47gvys 320 5 instillation instillation NN cord-304556-1f47gvys 320 6 after after IN cord-304556-1f47gvys 320 7 bleomycin bleomycin NN cord-304556-1f47gvys 320 8 attenuates attenuate VBZ cord-304556-1f47gvys 320 9 lung lung NN cord-304556-1f47gvys 320 10 injury injury NN cord-304556-1f47gvys 320 11 through through IN cord-304556-1f47gvys 320 12 hepatocyte hepatocyte NN cord-304556-1f47gvys 320 13 growth growth NN cord-304556-1f47gvys 320 14 factor factor NN cord-304556-1f47gvys 320 15 induction induction NN cord-304556-1f47gvys 320 16 Viral viral JJ cord-304556-1f47gvys 320 17 apoptotic apoptotic JJ cord-304556-1f47gvys 320 18 mimicry mimicry NN cord-304556-1f47gvys 321 1 Phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 321 2 receptors receptor NNS cord-304556-1f47gvys 321 3 : : : cord-304556-1f47gvys 322 1 enhancers enhancer NNS cord-304556-1f47gvys 322 2 of of IN cord-304556-1f47gvys 322 3 enveloped envelop VBN cord-304556-1f47gvys 322 4 virus virus NN cord-304556-1f47gvys 322 5 entry entry NN cord-304556-1f47gvys 322 6 and and CC cord-304556-1f47gvys 322 7 infection infection NN cord-304556-1f47gvys 322 8 TIM TIM NNP cord-304556-1f47gvys 322 9 - - HYPH cord-304556-1f47gvys 322 10 family family NN cord-304556-1f47gvys 322 11 proteins protein NNS cord-304556-1f47gvys 322 12 promote promote VBP cord-304556-1f47gvys 322 13 infection infection NN cord-304556-1f47gvys 322 14 of of IN cord-304556-1f47gvys 322 15 multiple multiple JJ cord-304556-1f47gvys 322 16 enveloped envelop VBN cord-304556-1f47gvys 322 17 viruses virus NNS cord-304556-1f47gvys 322 18 through through IN cord-304556-1f47gvys 322 19 virion virion NN cord-304556-1f47gvys 322 20 - - HYPH cord-304556-1f47gvys 322 21 associated associate VBN cord-304556-1f47gvys 322 22 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 323 1 The the DT cord-304556-1f47gvys 323 2 TIM TIM NNP cord-304556-1f47gvys 323 3 and and CC cord-304556-1f47gvys 323 4 TAM TAM NNP cord-304556-1f47gvys 323 5 families family NNS cord-304556-1f47gvys 323 6 of of IN cord-304556-1f47gvys 323 7 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 323 8 receptors receptor NNS cord-304556-1f47gvys 323 9 mediate mediate VBP cord-304556-1f47gvys 323 10 dengue dengue NN cord-304556-1f47gvys 323 11 virus virus NN cord-304556-1f47gvys 323 12 entry entry NN cord-304556-1f47gvys 323 13 Macrophages macrophage NNS cord-304556-1f47gvys 323 14 clean clean VBP cord-304556-1f47gvys 323 15 up up RP cord-304556-1f47gvys 323 16 : : : cord-304556-1f47gvys 324 1 efferocytosis efferocytosis NNP cord-304556-1f47gvys 324 2 and and CC cord-304556-1f47gvys 324 3 microbial microbial JJ cord-304556-1f47gvys 324 4 control control NN cord-304556-1f47gvys 324 5 Evasion Evasion NNP cord-304556-1f47gvys 324 6 of of IN cord-304556-1f47gvys 324 7 innate innate JJ cord-304556-1f47gvys 324 8 immunity immunity NN cord-304556-1f47gvys 324 9 by by IN cord-304556-1f47gvys 324 10 Mycobacterium Mycobacterium NNP cord-304556-1f47gvys 324 11 tuberculosis tuberculosis NN cord-304556-1f47gvys 324 12 : : : cord-304556-1f47gvys 324 13 is be VBZ cord-304556-1f47gvys 324 14 death death NN cord-304556-1f47gvys 324 15 an an DT cord-304556-1f47gvys 324 16 exit exit NN cord-304556-1f47gvys 324 17 strategy strategy NN cord-304556-1f47gvys 324 18 ? ? . cord-304556-1f47gvys 325 1 Efferocytosis efferocytosis NN cord-304556-1f47gvys 325 2 is be VBZ cord-304556-1f47gvys 325 3 an an DT cord-304556-1f47gvys 325 4 innate innate JJ cord-304556-1f47gvys 325 5 antibacterial antibacterial JJ cord-304556-1f47gvys 325 6 mechanism mechanism NN cord-304556-1f47gvys 325 7 Immunemediated immunemediate VBN cord-304556-1f47gvys 325 8 phagocytosis phagocytosis NN cord-304556-1f47gvys 325 9 and and CC cord-304556-1f47gvys 325 10 killing killing NN cord-304556-1f47gvys 325 11 of of IN cord-304556-1f47gvys 325 12 Streptococcus Streptococcus NNP cord-304556-1f47gvys 325 13 pneumoniae pneumoniae NNS cord-304556-1f47gvys 325 14 are be VBP cord-304556-1f47gvys 325 15 associated associate VBN cord-304556-1f47gvys 325 16 with with IN cord-304556-1f47gvys 326 1 direct direct JJ cord-304556-1f47gvys 326 2 and and CC cord-304556-1f47gvys 326 3 bystander bystander NN cord-304556-1f47gvys 326 4 macrophage macrophage NN cord-304556-1f47gvys 326 5 apoptosis apoptosis NN cord-304556-1f47gvys 326 6 Annexin1 Annexin1 NNP cord-304556-1f47gvys 326 7 regulates regulate VBZ cord-304556-1f47gvys 326 8 DC DC NNP cord-304556-1f47gvys 326 9 efferocytosis efferocytosis NN cord-304556-1f47gvys 326 10 and and CC cord-304556-1f47gvys 326 11 cross cross NN cord-304556-1f47gvys 326 12 - - NN cord-304556-1f47gvys 326 13 presentation presentation NN cord-304556-1f47gvys 326 14 during during IN cord-304556-1f47gvys 326 15 Mycobacterium Mycobacterium NNP cord-304556-1f47gvys 326 16 tuberculosis tuberculosis NN cord-304556-1f47gvys 326 17 infection infection NN cord-304556-1f47gvys 326 18 Virus virus NN cord-304556-1f47gvys 326 19 clearance clearance NN cord-304556-1f47gvys 326 20 through through IN cord-304556-1f47gvys 326 21 apoptosis apoptosis NN cord-304556-1f47gvys 326 22 - - HYPH cord-304556-1f47gvys 326 23 dependent dependent JJ cord-304556-1f47gvys 326 24 phagocytosis phagocytosis NN cord-304556-1f47gvys 326 25 of of IN cord-304556-1f47gvys 326 26 influenza influenza NN cord-304556-1f47gvys 326 27 A a DT cord-304556-1f47gvys 326 28 virus virus NN cord-304556-1f47gvys 326 29 - - HYPH cord-304556-1f47gvys 326 30 infected infect VBN cord-304556-1f47gvys 326 31 cells cell NNS cord-304556-1f47gvys 326 32 by by IN cord-304556-1f47gvys 326 33 macrophages macrophage NNS cord-304556-1f47gvys 326 34 Defect Defect NNP cord-304556-1f47gvys 326 35 in in IN cord-304556-1f47gvys 326 36 efferocytosis efferocytosis NN cord-304556-1f47gvys 326 37 leads lead VBZ cord-304556-1f47gvys 326 38 to to IN cord-304556-1f47gvys 326 39 alternative alternative JJ cord-304556-1f47gvys 326 40 activation activation NN cord-304556-1f47gvys 326 41 of of IN cord-304556-1f47gvys 326 42 macrophages macrophage NNS cord-304556-1f47gvys 326 43 in in IN cord-304556-1f47gvys 326 44 Francisella Francisella NNP cord-304556-1f47gvys 326 45 infections infection NNS cord-304556-1f47gvys 327 1 Glucocorticoidaugmented Glucocorticoidaugmented NNP cord-304556-1f47gvys 327 2 efferocytosis efferocytosis NN cord-304556-1f47gvys 327 3 inhibits inhibit VBZ cord-304556-1f47gvys 327 4 pulmonary pulmonary JJ cord-304556-1f47gvys 327 5 pneumococcal pneumococcal JJ cord-304556-1f47gvys 327 6 clearance clearance NN cord-304556-1f47gvys 327 7 in in IN cord-304556-1f47gvys 327 8 mice mouse NNS cord-304556-1f47gvys 327 9 by by IN cord-304556-1f47gvys 327 10 reducing reduce VBG cord-304556-1f47gvys 327 11 alveolar alveolar NN cord-304556-1f47gvys 327 12 macrophage macrophage NN cord-304556-1f47gvys 327 13 bactericidal bactericidal JJ cord-304556-1f47gvys 327 14 function function NN cord-304556-1f47gvys 327 15 Glucocorticoids Glucocorticoids NNP cord-304556-1f47gvys 327 16 promote promote VB cord-304556-1f47gvys 327 17 nonphlogistic nonphlogistic JJ cord-304556-1f47gvys 327 18 phagocytosis phagocytosis NN cord-304556-1f47gvys 327 19 of of IN cord-304556-1f47gvys 327 20 apoptotic apoptotic JJ cord-304556-1f47gvys 327 21 leukocytes leukocyte NNS cord-304556-1f47gvys 327 22 Glucocorticoids Glucocorticoids NNP cord-304556-1f47gvys 327 23 induce induce VBP cord-304556-1f47gvys 327 24 protein protein NN cord-304556-1f47gvys 327 25 Sdependent Sdependent NNP cord-304556-1f47gvys 327 26 phagocytosis phagocytosis NN cord-304556-1f47gvys 327 27 of of IN cord-304556-1f47gvys 327 28 apoptotic apoptotic JJ cord-304556-1f47gvys 327 29 neutrophils neutrophil NNS cord-304556-1f47gvys 327 30 by by IN cord-304556-1f47gvys 327 31 human human JJ cord-304556-1f47gvys 327 32 macrophages macrophage NNS cord-304556-1f47gvys 327 33 Efficient efficient JJ cord-304556-1f47gvys 327 34 clearance clearance NN cord-304556-1f47gvys 327 35 of of IN cord-304556-1f47gvys 327 36 early early JJ cord-304556-1f47gvys 327 37 apoptotic apoptotic JJ cord-304556-1f47gvys 327 38 cells cell NNS cord-304556-1f47gvys 327 39 by by IN cord-304556-1f47gvys 327 40 human human JJ cord-304556-1f47gvys 327 41 macrophages macrophage NNS cord-304556-1f47gvys 327 42 requires require VBZ cord-304556-1f47gvys 327 43 M2c m2c JJ cord-304556-1f47gvys 327 44 polarization polarization NN cord-304556-1f47gvys 327 45 and and CC cord-304556-1f47gvys 327 46 MerTK mertk NN cord-304556-1f47gvys 327 47 induction induction NN cord-304556-1f47gvys 328 1 Glucocorticoids Glucocorticoids NNP cord-304556-1f47gvys 328 2 relieve relieve VBP cord-304556-1f47gvys 328 3 collectin collectin NN cord-304556-1f47gvys 328 4 - - HYPH cord-304556-1f47gvys 328 5 driven drive VBN cord-304556-1f47gvys 328 6 suppression suppression NN cord-304556-1f47gvys 328 7 of of IN cord-304556-1f47gvys 328 8 apoptotic apoptotic JJ cord-304556-1f47gvys 328 9 cell cell NN cord-304556-1f47gvys 328 10 uptake uptake NN cord-304556-1f47gvys 328 11 in in IN cord-304556-1f47gvys 328 12 murine murine JJ cord-304556-1f47gvys 328 13 alveolar alveolar NN cord-304556-1f47gvys 328 14 macrophages macrophage NNS cord-304556-1f47gvys 328 15 through through IN cord-304556-1f47gvys 328 16 downregulation downregulation NN cord-304556-1f47gvys 328 17 of of IN cord-304556-1f47gvys 328 18 SIRPalpha SIRPalpha NNP cord-304556-1f47gvys 328 19 Fourteen Fourteen NNP cord-304556-1f47gvys 328 20 - - HYPH cord-304556-1f47gvys 328 21 member member NN cord-304556-1f47gvys 328 22 macrolides macrolide NNS cord-304556-1f47gvys 328 23 promote promote VBP cord-304556-1f47gvys 328 24 the the DT cord-304556-1f47gvys 328 25 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 328 26 receptor receptor NN cord-304556-1f47gvys 328 27 - - HYPH cord-304556-1f47gvys 328 28 dependent dependent JJ cord-304556-1f47gvys 328 29 phagocytosis phagocytosis NN cord-304556-1f47gvys 328 30 of of IN cord-304556-1f47gvys 328 31 apoptotic apoptotic JJ cord-304556-1f47gvys 328 32 neutrophils neutrophil NNS cord-304556-1f47gvys 328 33 by by IN cord-304556-1f47gvys 328 34 alveolar alveolar NN cord-304556-1f47gvys 328 35 macrophages macrophage NNS cord-304556-1f47gvys 328 36 Azithromycin Azithromycin NNP cord-304556-1f47gvys 328 37 for for IN cord-304556-1f47gvys 328 38 prevention prevention NN cord-304556-1f47gvys 328 39 of of IN cord-304556-1f47gvys 328 40 exacerbations exacerbation NNS cord-304556-1f47gvys 328 41 of of IN cord-304556-1f47gvys 328 42 COPD COPD NNP cord-304556-1f47gvys 328 43 Antiinflammatory antiinflammatory JJ cord-304556-1f47gvys 328 44 roles role NNS cord-304556-1f47gvys 328 45 of of IN cord-304556-1f47gvys 328 46 peroxisome peroxisome NN cord-304556-1f47gvys 328 47 proliferator proliferator NN cord-304556-1f47gvys 328 48 - - HYPH cord-304556-1f47gvys 328 49 activated activate VBN cord-304556-1f47gvys 328 50 receptor receptor NN cord-304556-1f47gvys 328 51 gamma gamma NN cord-304556-1f47gvys 328 52 in in IN cord-304556-1f47gvys 328 53 human human JJ cord-304556-1f47gvys 328 54 alveolar alveolar NN cord-304556-1f47gvys 328 55 macrophages macrophage NNS cord-304556-1f47gvys 329 1 The the DT cord-304556-1f47gvys 329 2 effect effect NN cord-304556-1f47gvys 329 3 of of IN cord-304556-1f47gvys 329 4 peroxisome peroxisome NN cord-304556-1f47gvys 329 5 proliferator proliferator NN cord-304556-1f47gvys 329 6 - - HYPH cord-304556-1f47gvys 329 7 activated activate VBN cord-304556-1f47gvys 329 8 receptorgamma receptorgamma JJ cord-304556-1f47gvys 329 9 ligands ligand NNS cord-304556-1f47gvys 329 10 on on IN cord-304556-1f47gvys 329 11 in in IN cord-304556-1f47gvys 329 12 vitro vitro FW cord-304556-1f47gvys 329 13 and and CC cord-304556-1f47gvys 329 14 in in IN cord-304556-1f47gvys 329 15 vivo vivo NN cord-304556-1f47gvys 329 16 models model NNS cord-304556-1f47gvys 329 17 of of IN cord-304556-1f47gvys 329 18 COPD COPD NNP cord-304556-1f47gvys 330 1 Lovastatin lovastatin NN cord-304556-1f47gvys 330 2 enhances enhance VBZ cord-304556-1f47gvys 330 3 clearance clearance NN cord-304556-1f47gvys 330 4 of of IN cord-304556-1f47gvys 330 5 apoptotic apoptotic JJ cord-304556-1f47gvys 330 6 cells cell NNS cord-304556-1f47gvys 330 7 ( ( -LRB- cord-304556-1f47gvys 330 8 efferocytosis efferocytosis NNP cord-304556-1f47gvys 330 9 ) ) -RRB- cord-304556-1f47gvys 330 10 with with IN cord-304556-1f47gvys 330 11 implications implication NNS cord-304556-1f47gvys 330 12 for for IN cord-304556-1f47gvys 330 13 chronic chronic JJ cord-304556-1f47gvys 330 14 obstructive obstructive JJ cord-304556-1f47gvys 330 15 pulmonary pulmonary JJ cord-304556-1f47gvys 330 16 disease disease NN cord-304556-1f47gvys 330 17 Statin Statin NNP cord-304556-1f47gvys 330 18 use use NN cord-304556-1f47gvys 330 19 is be VBZ cord-304556-1f47gvys 330 20 associated associate VBN cord-304556-1f47gvys 330 21 with with IN cord-304556-1f47gvys 330 22 reduced reduce VBN cord-304556-1f47gvys 330 23 mortality mortality NN cord-304556-1f47gvys 330 24 in in IN cord-304556-1f47gvys 330 25 COPD COPD NNP cord-304556-1f47gvys 330 26 Statin Statin NNP cord-304556-1f47gvys 330 27 use use NN cord-304556-1f47gvys 330 28 and and CC cord-304556-1f47gvys 330 29 risk risk NN cord-304556-1f47gvys 330 30 of of IN cord-304556-1f47gvys 330 31 COPD COPD NNP cord-304556-1f47gvys 330 32 exacerbation exacerbation NN cord-304556-1f47gvys 330 33 requiring require VBG cord-304556-1f47gvys 330 34 hospitalization hospitalization NN cord-304556-1f47gvys 330 35 Simvastatin Simvastatin NNP cord-304556-1f47gvys 330 36 for for IN cord-304556-1f47gvys 330 37 the the DT cord-304556-1f47gvys 330 38 prevention prevention NN cord-304556-1f47gvys 330 39 of of IN cord-304556-1f47gvys 330 40 exacerbations exacerbation NNS cord-304556-1f47gvys 330 41 in in IN cord-304556-1f47gvys 330 42 moderate moderate JJ cord-304556-1f47gvys 330 43 - - HYPH cord-304556-1f47gvys 330 44 to to IN cord-304556-1f47gvys 330 45 - - HYPH cord-304556-1f47gvys 330 46 severe severe JJ cord-304556-1f47gvys 330 47 COPD COPD NNP cord-304556-1f47gvys 331 1 The the DT cord-304556-1f47gvys 331 2 TAM TAM NNP cord-304556-1f47gvys 331 3 family family NN cord-304556-1f47gvys 331 4 : : : cord-304556-1f47gvys 332 1 phosphatidylserine phosphatidylserine NN cord-304556-1f47gvys 332 2 sensing sensing NN cord-304556-1f47gvys 332 3 receptor receptor NN cord-304556-1f47gvys 332 4 tyrosine tyrosine NN cord-304556-1f47gvys 332 5 kinases kinase NNS cord-304556-1f47gvys 332 6 gone go VBN cord-304556-1f47gvys 332 7 awry awry JJ cord-304556-1f47gvys 332 8 in in IN cord-304556-1f47gvys 332 9 cancer cancer NN cord-304556-1f47gvys 332 10 Upregulation Upregulation NNP cord-304556-1f47gvys 332 11 of of IN cord-304556-1f47gvys 332 12 Mer Mer NNP cord-304556-1f47gvys 332 13 receptor receptor NN cord-304556-1f47gvys 332 14 tyrosine tyrosine NN cord-304556-1f47gvys 332 15 kinase kinase NN cord-304556-1f47gvys 332 16 signaling signal VBG cord-304556-1f47gvys 332 17 attenuated attenuated JJ cord-304556-1f47gvys 332 18 lipopolysaccharide lipopolysaccharide NN cord-304556-1f47gvys 332 19 - - HYPH cord-304556-1f47gvys 332 20 induced induce VBN cord-304556-1f47gvys 332 21 lung lung NN cord-304556-1f47gvys 332 22 inflammation inflammation NN cord-304556-1f47gvys 332 23 Inhibiting inhibit VBG cord-304556-1f47gvys 332 24 Mer Mer NNP cord-304556-1f47gvys 332 25 receptor receptor NN cord-304556-1f47gvys 332 26 tyrosine tyrosine NN cord-304556-1f47gvys 332 27 kinase kinase NN cord-304556-1f47gvys 332 28 suppresses suppress VBZ cord-304556-1f47gvys 332 29 STAT1 stat1 XX cord-304556-1f47gvys 332 30 , , , cord-304556-1f47gvys 333 1 SOCS1/3 SOCS1/3 NNP cord-304556-1f47gvys 333 2 , , , cord-304556-1f47gvys 333 3 and and CC cord-304556-1f47gvys 333 4 NF NF NNP cord-304556-1f47gvys 333 5 - - HYPH cord-304556-1f47gvys 333 6 kappaB kappaB NNP cord-304556-1f47gvys 333 7 activation activation NN cord-304556-1f47gvys 333 8 and and CC cord-304556-1f47gvys 333 9 enhances enhance VBZ cord-304556-1f47gvys 333 10 inflammatory inflammatory JJ cord-304556-1f47gvys 333 11 responses response NNS cord-304556-1f47gvys 333 12 in in IN cord-304556-1f47gvys 333 13 lipopolysaccharide lipopolysaccharide NN cord-304556-1f47gvys 333 14 - - HYPH cord-304556-1f47gvys 333 15 induced induce VBN cord-304556-1f47gvys 333 16 acute acute JJ cord-304556-1f47gvys 333 17 lung lung NN cord-304556-1f47gvys 333 18 injury injury NN cord-304556-1f47gvys 334 1 The the DT cord-304556-1f47gvys 334 2 AXL AXL NNP cord-304556-1f47gvys 334 3 receptor receptor NN cord-304556-1f47gvys 334 4 is be VBZ cord-304556-1f47gvys 334 5 a a DT cord-304556-1f47gvys 334 6 sensor sensor NN cord-304556-1f47gvys 334 7 of of IN cord-304556-1f47gvys 334 8 ligand ligand NN cord-304556-1f47gvys 334 9 spatial spatial JJ cord-304556-1f47gvys 334 10 heterogeneity heterogeneity NN cord-304556-1f47gvys 334 11 A a DT cord-304556-1f47gvys 334 12 soluble soluble JJ cord-304556-1f47gvys 334 13 form form NN cord-304556-1f47gvys 334 14 of of IN cord-304556-1f47gvys 334 15 the the DT cord-304556-1f47gvys 334 16 Mer Mer NNP cord-304556-1f47gvys 334 17 receptor receptor NN cord-304556-1f47gvys 334 18 tyrosine tyrosine NN cord-304556-1f47gvys 334 19 kinase kinase NN cord-304556-1f47gvys 334 20 inhibits inhibit VBZ cord-304556-1f47gvys 334 21 macrophage macrophage NN cord-304556-1f47gvys 334 22 clearance clearance NN cord-304556-1f47gvys 334 23 of of IN cord-304556-1f47gvys 334 24 apoptotic apoptotic JJ cord-304556-1f47gvys 334 25 cells cell NNS cord-304556-1f47gvys 334 26 and and CC cord-304556-1f47gvys 334 27 platelet platelet NN cord-304556-1f47gvys 334 28 aggregation aggregation NN cord-304556-1f47gvys 334 29 Plasma plasma NN cord-304556-1f47gvys 334 30 concentrations concentration NNS cord-304556-1f47gvys 334 31 of of IN cord-304556-1f47gvys 334 32 Gas6 Gas6 NNP cord-304556-1f47gvys 334 33 ( ( -LRB- cord-304556-1f47gvys 334 34 growth growth NN cord-304556-1f47gvys 334 35 arrest arrest NN cord-304556-1f47gvys 334 36 specific specific JJ cord-304556-1f47gvys 334 37 protein protein NN cord-304556-1f47gvys 334 38 6 6 CD cord-304556-1f47gvys 334 39 ) ) -RRB- cord-304556-1f47gvys 334 40 and and CC cord-304556-1f47gvys 334 41 its -PRON- PRP$ cord-304556-1f47gvys 334 42 soluble soluble JJ cord-304556-1f47gvys 334 43 tyrosine tyrosine NN cord-304556-1f47gvys 334 44 kinase kinase NN cord-304556-1f47gvys 334 45 receptor receptor NN cord-304556-1f47gvys 334 46 sAxl sAxl NNP cord-304556-1f47gvys 334 47 in in IN cord-304556-1f47gvys 334 48 sepsis sepsis NN cord-304556-1f47gvys 334 49 and and CC cord-304556-1f47gvys 334 50 systemic systemic JJ cord-304556-1f47gvys 334 51 inflammatory inflammatory JJ cord-304556-1f47gvys 334 52 response response NN cord-304556-1f47gvys 334 53 syndromes syndrome NNS cord-304556-1f47gvys 335 1 Increased increase VBN cord-304556-1f47gvys 335 2 plasma plasma NN cord-304556-1f47gvys 335 3 levels level NNS cord-304556-1f47gvys 335 4 of of IN cord-304556-1f47gvys 335 5 the the DT cord-304556-1f47gvys 335 6 soluble soluble JJ cord-304556-1f47gvys 335 7 Mer Mer NNP cord-304556-1f47gvys 335 8 tyrosine tyrosine NN cord-304556-1f47gvys 335 9 kinase kinase NN cord-304556-1f47gvys 335 10 receptor receptor NN cord-304556-1f47gvys 335 11 in in IN cord-304556-1f47gvys 335 12 systemic systemic JJ cord-304556-1f47gvys 335 13 lupus lupus NN cord-304556-1f47gvys 335 14 erythematosus erythematosus NN cord-304556-1f47gvys 335 15 relate relate VBP cord-304556-1f47gvys 335 16 to to IN cord-304556-1f47gvys 335 17 disease disease NN cord-304556-1f47gvys 335 18 activity activity NN cord-304556-1f47gvys 335 19 and and CC cord-304556-1f47gvys 335 20 nephritis nephritis NN