id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-273594-vmbhok1u	Sichelstiel, Anke	Targeting IL-1β and IL-17A Driven Inflammation during Influenza-Induced Exacerbations of Chronic Lung Inflammation	2014-06-11		.txt	text/plain	5621	285	43	In order to investigate the role of IL-1b during COPD exacerbations we utilized a model of LPS and elastase induced chronic lung inflammation, followed by infection with influenza in wild type or IL-1b deficient mice. To study viral-induced exacerbations, mice were infected with influenza virus 2 weeks after the last LPS/elastase challenge, when the acute inflammation caused by LPS/elastase exposure had subsided ( Figure 2A ). Acute pulmonary dysfunction, neutrophilic inflammation and enhanced levels of proinflammatory cytokines such as IL-6 and TNFa have all been observed during exacerbations of COPD patients, indicating that the viral-induced inflammation in our mouse model is in line with that seen in humans. As we observed an increase of IL-1b protein in the lungs of LPS/elastase treated mice upon influenza infection ( Figure 3A ), we hypothesized that it also promotes innate immune responses and influences pulmonary function during exacerbations.	./cache/cord-273594-vmbhok1u.txt	./txt/cord-273594-vmbhok1u.txt