id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-015674-d4h9016a	Provost, Karin	Infectious Mechanisms Regulating Susceptibility to Acute Exacerbations of COPD	2013-07-13		.txt	text/plain	5851	262	34	Despite the recruitment of appropriate effector immune cells, in many patients with advanced stage COPD (GOLD III-IV), there is persistent presence of pathogens in the airway, rather than eradication [ 19 , 28 ] , suggesting an impaired host response to infection. Advancing diagnostic techniques of bronchoscopy with protected specimen brushes and bronchoalveolar lavage, as well as molecular bacterial typing allowed identifi cation of bacteria ( Streptococcus pneumoniae , Haemophilus infl uenzae , Moraxella catarrhalis , and Pseudomonas aeruginosa and others at potentially pathogenic concentrations) in the distal airways in stable COPD [ 9 , 17 , 28 , 40 , 41 , 46 -51 ] , with more severe GOLD stage disease being associated with identifi cation of Pseudomonas. Infections and airway infl ammation in chronic obstructive pulmonary disease severe exacerbations	./cache/cord-015674-d4h9016a.txt	./txt/cord-015674-d4h9016a.txt