id	sid	tid	token	lemma	pos
cord-006139-9063uhox	1	1	key	key	JJ
cord-006139-9063uhox	1	2	:	:	:
cord-006139-9063uhox	1	3	cord-006139	cord-006139	NN
cord-006139-9063uhox	1	4	-	-	HYPH
cord-006139-9063uhox	1	5	9063uhox	9063uhox	CD
cord-006139-9063uhox	1	6	authors	author	NNS
cord-006139-9063uhox	1	7	:	:	:
cord-006139-9063uhox	1	8	Egan	Egan	NNP
cord-006139-9063uhox	1	9	,	,	,
cord-006139-9063uhox	1	10	Timothy	Timothy	NNP
cord-006139-9063uhox	1	11	J	J	NNP
cord-006139-9063uhox	1	12	;	;	:
cord-006139-9063uhox	1	13	Kuter	Kuter	NNP
cord-006139-9063uhox	1	14	,	,	,
cord-006139-9063uhox	1	15	David	David	NNP
cord-006139-9063uhox	1	16	title	title	NN
cord-006139-9063uhox	1	17	:	:	:
cord-006139-9063uhox	1	18	Dual	dual	JJ
cord-006139-9063uhox	1	19	-	-	HYPH
cord-006139-9063uhox	1	20	functioning	function	VBG
cord-006139-9063uhox	1	21	antimalarials	antimalarial	NNS
cord-006139-9063uhox	1	22	that	that	WDT
cord-006139-9063uhox	1	23	inhibit	inhibit	VBP
cord-006139-9063uhox	1	24	the	the	DT
cord-006139-9063uhox	1	25	chloroquine	chloroquine	NN
cord-006139-9063uhox	1	26	-	-	HYPH
cord-006139-9063uhox	1	27	resistance	resistance	NN
cord-006139-9063uhox	1	28	transporter	transporter	NN
cord-006139-9063uhox	1	29	date	date	NN
cord-006139-9063uhox	1	30	:	:	:
cord-006139-9063uhox	1	31	2013	2013	CD
cord-006139-9063uhox	1	32	-	-	SYM
cord-006139-9063uhox	1	33	03	03	CD
cord-006139-9063uhox	1	34	-	-	HYPH
cord-006139-9063uhox	1	35	27	27	CD
cord-006139-9063uhox	1	36	journal	journal	NN
cord-006139-9063uhox	1	37	:	:	:
cord-006139-9063uhox	2	1	Future	future	JJ
cord-006139-9063uhox	2	2	Microbiol	Microbiol	NNP
cord-006139-9063uhox	2	3	DOI	DOI	NNP
cord-006139-9063uhox	2	4	:	:	:
cord-006139-9063uhox	2	5	10.2217	10.2217	CD
cord-006139-9063uhox	2	6	/	/	SYM
cord-006139-9063uhox	2	7	fmb.13.18	fmb.13.18	NN
cord-006139-9063uhox	2	8	sha	sha	NNP
cord-006139-9063uhox	2	9	:	:	:
cord-006139-9063uhox	2	10	f8fcdaf6c227c969f752cdc743def7742e051232	f8fcdaf6c227c969f752cdc743def7742e051232	NNP
cord-006139-9063uhox	2	11	doc_id	doc_id	CD
cord-006139-9063uhox	2	12	:	:	:
cord-006139-9063uhox	2	13	6139	6139	CD
cord-006139-9063uhox	2	14	cord_uid	cord_uid	NNS
cord-006139-9063uhox	2	15	:	:	:
cord-006139-9063uhox	3	1	9063uhox	9063uhox	CD
cord-006139-9063uhox	3	2	Malaria	Malaria	NNP
cord-006139-9063uhox	3	3	remains	remain	VBZ
cord-006139-9063uhox	3	4	a	a	DT
cord-006139-9063uhox	3	5	major	major	JJ
cord-006139-9063uhox	3	6	international	international	JJ
cord-006139-9063uhox	3	7	health	health	NN
cord-006139-9063uhox	3	8	challenge	challenge	NN
cord-006139-9063uhox	3	9	.	.	.
cord-006139-9063uhox	4	1	Resistance	resistance	NN
cord-006139-9063uhox	4	2	to	to	IN
cord-006139-9063uhox	4	3	a	a	DT
cord-006139-9063uhox	4	4	number	number	NN
cord-006139-9063uhox	4	5	of	of	IN
cord-006139-9063uhox	4	6	existing	exist	VBG
cord-006139-9063uhox	4	7	drugs	drug	NNS
cord-006139-9063uhox	4	8	and	and	CC
cord-006139-9063uhox	4	9	evidence	evidence	NN
cord-006139-9063uhox	4	10	of	of	IN
cord-006139-9063uhox	4	11	the	the	DT
cord-006139-9063uhox	4	12	emergence	emergence	NN
cord-006139-9063uhox	4	13	of	of	IN
cord-006139-9063uhox	4	14	artemisinin	artemisinin	NN
cord-006139-9063uhox	4	15	resistance	resistance	NN
cord-006139-9063uhox	4	16	has	have	VBZ
cord-006139-9063uhox	4	17	emphasized	emphasize	VBN
cord-006139-9063uhox	4	18	the	the	DT
cord-006139-9063uhox	4	19	need	need	NN
cord-006139-9063uhox	4	20	for	for	IN
cord-006139-9063uhox	4	21	new	new	JJ
cord-006139-9063uhox	4	22	antimalarials	antimalarial	NNS
cord-006139-9063uhox	4	23	.	.	.
cord-006139-9063uhox	5	1	A	a	DT
cord-006139-9063uhox	5	2	new	new	JJ
cord-006139-9063uhox	5	3	approach	approach	NN
cord-006139-9063uhox	5	4	has	have	VBZ
cord-006139-9063uhox	5	5	been	be	VBN
cord-006139-9063uhox	5	6	the	the	DT
cord-006139-9063uhox	5	7	preparation	preparation	NN
cord-006139-9063uhox	5	8	of	of	IN
cord-006139-9063uhox	5	9	dual	dual	JJ
cord-006139-9063uhox	5	10	-	-	HYPH
cord-006139-9063uhox	5	11	function	function	NN
cord-006139-9063uhox	5	12	compounds	compound	NNS
cord-006139-9063uhox	5	13	that	that	WDT
cord-006139-9063uhox	5	14	include	include	VBP
cord-006139-9063uhox	5	15	a	a	DT
cord-006139-9063uhox	5	16	chloroquine	chloroquine	NN
cord-006139-9063uhox	5	17	-	-	HYPH
cord-006139-9063uhox	5	18	like	like	JJ
cord-006139-9063uhox	5	19	antimalarial	antimalarial	JJ
cord-006139-9063uhox	5	20	group	group	NN
cord-006139-9063uhox	5	21	and	and	CC
cord-006139-9063uhox	5	22	a	a	DT
cord-006139-9063uhox	5	23	group	group	NN
cord-006139-9063uhox	5	24	that	that	WDT
cord-006139-9063uhox	5	25	resembles	resemble	VBZ
cord-006139-9063uhox	5	26	a	a	DT
cord-006139-9063uhox	5	27	chloroquine	chloroquine	NN
cord-006139-9063uhox	5	28	chemosensitizer	chemosensitizer	NN
cord-006139-9063uhox	5	29	.	.	.
cord-006139-9063uhox	6	1	This	this	DT
cord-006139-9063uhox	6	2	article	article	NN
cord-006139-9063uhox	6	3	reviews	review	VBZ
cord-006139-9063uhox	6	4	the	the	DT
cord-006139-9063uhox	6	5	recent	recent	JJ
cord-006139-9063uhox	6	6	discovery	discovery	NN
cord-006139-9063uhox	6	7	of	of	IN
cord-006139-9063uhox	6	8	such	such	JJ
cord-006139-9063uhox	6	9	dual	dual	JJ
cord-006139-9063uhox	6	10	-	-	HYPH
cord-006139-9063uhox	6	11	function	function	NN
cord-006139-9063uhox	6	12	antimalarials	antimalarial	NNS
cord-006139-9063uhox	6	13	that	that	WDT
cord-006139-9063uhox	6	14	are	be	VBP
cord-006139-9063uhox	6	15	proposed	propose	VBN
cord-006139-9063uhox	6	16	to	to	TO
cord-006139-9063uhox	6	17	target	target	VB
cord-006139-9063uhox	6	18	both	both	DT
cord-006139-9063uhox	6	19	hemozoin	hemozoin	NNP
cord-006139-9063uhox	6	20	formation	formation	NN
cord-006139-9063uhox	6	21	and	and	CC
cord-006139-9063uhox	6	22	the	the	DT
cord-006139-9063uhox	6	23	chloroquine	chloroquine	NN
cord-006139-9063uhox	6	24	resistance	resistance	NN
cord-006139-9063uhox	6	25	transporter	transporter	NN
cord-006139-9063uhox	6	26	,	,	,
cord-006139-9063uhox	6	27	PfCRT	PfCRT	NNP
cord-006139-9063uhox	6	28	.	.	.
cord-006139-9063uhox	7	1	These	these	DT
cord-006139-9063uhox	7	2	are	be	VBP
cord-006139-9063uhox	7	3	discussed	discuss	VBN
cord-006139-9063uhox	7	4	in	in	IN
cord-006139-9063uhox	7	5	relation	relation	NN
cord-006139-9063uhox	7	6	to	to	IN
cord-006139-9063uhox	7	7	the	the	DT
cord-006139-9063uhox	7	8	mechanism	mechanism	NN
cord-006139-9063uhox	7	9	of	of	IN
cord-006139-9063uhox	7	10	action	action	NN
cord-006139-9063uhox	7	11	of	of	IN
cord-006139-9063uhox	7	12	4-aminoquinolines	4-aminoquinolines	CD
cord-006139-9063uhox	7	13	,	,	,
cord-006139-9063uhox	7	14	chloroquine	chloroquine	NN
cord-006139-9063uhox	7	15	resistance	resistance	NN
cord-006139-9063uhox	7	16	and	and	CC
cord-006139-9063uhox	7	17	resistance	resistance	NN
cord-006139-9063uhox	7	18	reversal	reversal	NN
cord-006139-9063uhox	7	19	.	.	.
cord-006139-9063uhox	8	1	According	accord	VBG
cord-006139-9063uhox	8	2	to	to	IN
cord-006139-9063uhox	8	3	the	the	DT
cord-006139-9063uhox	8	4	WHO	WHO	NNP
cord-006139-9063uhox	8	5	World	World	NNP
cord-006139-9063uhox	8	6	Malaria	Malaria	NNP
cord-006139-9063uhox	8	7	Report	Report	NNP
cord-006139-9063uhox	8	8	of	of	IN
cord-006139-9063uhox	8	9	2011	2011	CD
cord-006139-9063uhox	8	10	,	,	,
cord-006139-9063uhox	8	11	there	there	EX
cord-006139-9063uhox	8	12	were	be	VBD
cord-006139-9063uhox	8	13	216	216	CD
cord-006139-9063uhox	8	14	million	million	CD
cord-006139-9063uhox	8	15	cases	case	NNS
cord-006139-9063uhox	8	16	of	of	IN
cord-006139-9063uhox	8	17	malaria	malaria	NN
cord-006139-9063uhox	8	18	in	in	IN
cord-006139-9063uhox	8	19	2010	2010	CD
cord-006139-9063uhox	8	20	,	,	,
cord-006139-9063uhox	8	21	with	with	IN
cord-006139-9063uhox	8	22	655,000	655,000	CD
cord-006139-9063uhox	8	23	deaths	death	NNS
cord-006139-9063uhox	8	24	,	,	,
cord-006139-9063uhox	8	25	91	91	CD
cord-006139-9063uhox	8	26	%	%	NN
cord-006139-9063uhox	8	27	of	of	IN
cord-006139-9063uhox	8	28	which	which	WDT
cord-006139-9063uhox	8	29	occurred	occur	VBD
cord-006139-9063uhox	8	30	in	in	IN
cord-006139-9063uhox	8	31	Africa	Africa	NNP
cord-006139-9063uhox	8	32	,	,	,
cord-006139-9063uhox	8	33	with	with	IN
cord-006139-9063uhox	8	34	86	86	CD
cord-006139-9063uhox	8	35	%	%	NN
cord-006139-9063uhox	8	36	of	of	IN
cord-006139-9063uhox	8	37	the	the	DT
cord-006139-9063uhox	8	38	victims	victim	NNS
cord-006139-9063uhox	8	39	being	be	VBG
cord-006139-9063uhox	8	40	children	child	NNS
cord-006139-9063uhox	8	41	under	under	IN
cord-006139-9063uhox	8	42	the	the	DT
cord-006139-9063uhox	8	43	age	age	NN
cord-006139-9063uhox	8	44	of	of	IN
cord-006139-9063uhox	8	45	5	5	CD
cord-006139-9063uhox	8	46	years	year	NNS
cord-006139-9063uhox	8	47	[	[	-LRB-
cord-006139-9063uhox	8	48	1	1	CD
cord-006139-9063uhox	8	49	]	]	-RRB-
cord-006139-9063uhox	8	50	.	.	.
cord-006139-9063uhox	9	1	Despite	despite	IN
cord-006139-9063uhox	9	2	a	a	DT
cord-006139-9063uhox	9	3	25	25	CD
cord-006139-9063uhox	9	4	%	%	NN
cord-006139-9063uhox	9	5	decrease	decrease	NN
cord-006139-9063uhox	9	6	in	in	IN
cord-006139-9063uhox	9	7	mortality	mortality	NN
cord-006139-9063uhox	9	8	since	since	IN
cord-006139-9063uhox	9	9	2000	2000	CD
cord-006139-9063uhox	9	10	,	,	,
cord-006139-9063uhox	9	11	one	one	CD
cord-006139-9063uhox	9	12	child	child	NN
cord-006139-9063uhox	9	13	still	still	RB
cord-006139-9063uhox	9	14	dies	die	VBZ
cord-006139-9063uhox	9	15	of	of	IN
cord-006139-9063uhox	9	16	malaria	malaria	NN
cord-006139-9063uhox	9	17	every	every	DT
cord-006139-9063uhox	9	18	minute	minute	NN
cord-006139-9063uhox	9	19	.	.	.
cord-006139-9063uhox	10	1	The	the	DT
cord-006139-9063uhox	10	2	disease	disease	NN
cord-006139-9063uhox	10	3	is	be	VBZ
cord-006139-9063uhox	10	4	caused	cause	VBN
cord-006139-9063uhox	10	5	by	by	IN
cord-006139-9063uhox	10	6	four	four	CD
cord-006139-9063uhox	10	7	species	specie	NNS
cord-006139-9063uhox	10	8	of	of	IN
cord-006139-9063uhox	10	9	protozoan	protozoan	NN
cord-006139-9063uhox	10	10	parasite	parasite	NN
cord-006139-9063uhox	10	11	of	of	IN
cord-006139-9063uhox	10	12	the	the	DT
cord-006139-9063uhox	10	13	genus	genus	NN
cord-006139-9063uhox	10	14	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	10	15	that	that	WDT
cord-006139-9063uhox	10	16	are	be	VBP
cord-006139-9063uhox	10	17	specific	specific	JJ
cord-006139-9063uhox	10	18	to	to	IN
cord-006139-9063uhox	10	19	humans	human	NNS
cord-006139-9063uhox	10	20	,	,	,
cord-006139-9063uhox	10	21	namely	namely	RB
cord-006139-9063uhox	10	22	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	10	23	falciparum	falciparum	NN
cord-006139-9063uhox	10	24	,	,	,
cord-006139-9063uhox	10	25	Plasmodium	plasmodium	NN
cord-006139-9063uhox	10	26	vivax	vivax	NN
cord-006139-9063uhox	10	27	,	,	,
cord-006139-9063uhox	10	28	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	10	29	malariae	malariae	NN
cord-006139-9063uhox	10	30	and	and	CC
cord-006139-9063uhox	10	31	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	10	32	ovale	ovale	NN
cord-006139-9063uhox	10	33	.	.	.
cord-006139-9063uhox	11	1	A	a	DT
cord-006139-9063uhox	11	2	fifth	fifth	JJ
cord-006139-9063uhox	11	3	species	specie	NNS
cord-006139-9063uhox	11	4	,	,	,
cord-006139-9063uhox	11	5	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	11	6	knowlesi	knowlesi	NN
cord-006139-9063uhox	11	7	,	,	,
cord-006139-9063uhox	11	8	which	which	WDT
cord-006139-9063uhox	11	9	primarily	primarily	RB
cord-006139-9063uhox	11	10	infects	infect	VBZ
cord-006139-9063uhox	11	11	monkeys	monkey	NNS
cord-006139-9063uhox	11	12	,	,	,
cord-006139-9063uhox	11	13	has	have	VBZ
cord-006139-9063uhox	11	14	also	also	RB
cord-006139-9063uhox	11	15	been	be	VBN
cord-006139-9063uhox	11	16	recognized	recognize	VBN
cord-006139-9063uhox	11	17	as	as	IN
cord-006139-9063uhox	11	18	a	a	DT
cord-006139-9063uhox	11	19	zoonotic	zoonotic	JJ
cord-006139-9063uhox	11	20	cause	cause	NN
cord-006139-9063uhox	11	21	of	of	IN
cord-006139-9063uhox	11	22	human	human	JJ
cord-006139-9063uhox	11	23	malaria	malaria	NN
cord-006139-9063uhox	11	24	in	in	IN
cord-006139-9063uhox	11	25	Indonesia	Indonesia	NNP
cord-006139-9063uhox	11	26	[	[	-LRB-
cord-006139-9063uhox	11	27	2	2	CD
cord-006139-9063uhox	11	28	]	]	-RRB-
cord-006139-9063uhox	11	29	.	.	.
cord-006139-9063uhox	12	1	Of	of	IN
cord-006139-9063uhox	12	2	these	these	DT
cord-006139-9063uhox	12	3	species	specie	NNS
cord-006139-9063uhox	12	4	,	,	,
cord-006139-9063uhox	12	5	P.	P.	NNP
cord-006139-9063uhox	12	6	falciparum	falciparum	NN
cord-006139-9063uhox	12	7	is	be	VBZ
cord-006139-9063uhox	12	8	the	the	DT
cord-006139-9063uhox	12	9	most	most	RBS
cord-006139-9063uhox	12	10	deadly	deadly	JJ
cord-006139-9063uhox	12	11	.	.	.
cord-006139-9063uhox	13	1	All	all	DT
cord-006139-9063uhox	13	2	are	be	VBP
cord-006139-9063uhox	13	3	transmitted	transmit	VBN
cord-006139-9063uhox	13	4	by	by	IN
cord-006139-9063uhox	13	5	mosquitoes	mosquito	NNS
cord-006139-9063uhox	13	6	of	of	IN
cord-006139-9063uhox	13	7	the	the	DT
cord-006139-9063uhox	13	8	genus	genus	NN
cord-006139-9063uhox	13	9	Anopheles	Anopheles	NNP
cord-006139-9063uhox	13	10	.	.	.
cord-006139-9063uhox	14	1	Control	control	NN
cord-006139-9063uhox	14	2	and	and	CC
cord-006139-9063uhox	14	3	eradication	eradication	NN
cord-006139-9063uhox	14	4	of	of	IN
cord-006139-9063uhox	14	5	malaria	malaria	NN
cord-006139-9063uhox	14	6	relies	rely	VBZ
cord-006139-9063uhox	14	7	on	on	IN
cord-006139-9063uhox	14	8	a	a	DT
cord-006139-9063uhox	14	9	multifaceted	multifaceted	JJ
cord-006139-9063uhox	14	10	strategy	strategy	NN
cord-006139-9063uhox	14	11	.	.	.
cord-006139-9063uhox	15	1	This	this	DT
cord-006139-9063uhox	15	2	involves	involve	VBZ
cord-006139-9063uhox	15	3	prevention	prevention	NN
cord-006139-9063uhox	15	4	of	of	IN
cord-006139-9063uhox	15	5	mosquito	mosquito	NN
cord-006139-9063uhox	15	6	bites	bite	NNS
cord-006139-9063uhox	15	7	using	use	VBG
cord-006139-9063uhox	15	8	screening	screening	NN
cord-006139-9063uhox	15	9	methods	method	NNS
cord-006139-9063uhox	15	10	,	,	,
cord-006139-9063uhox	15	11	elimination	elimination	NN
cord-006139-9063uhox	15	12	of	of	IN
cord-006139-9063uhox	15	13	mosquitoes	mosquito	NNS
cord-006139-9063uhox	15	14	and	and	CC
cord-006139-9063uhox	15	15	treatment	treatment	NN
cord-006139-9063uhox	15	16	of	of	IN
cord-006139-9063uhox	15	17	infected	infected	JJ
cord-006139-9063uhox	15	18	individuals	individual	NNS
cord-006139-9063uhox	15	19	to	to	TO
cord-006139-9063uhox	15	20	eliminate	eliminate	VB
cord-006139-9063uhox	15	21	the	the	DT
cord-006139-9063uhox	15	22	parasite	parasite	NN
cord-006139-9063uhox	15	23	from	from	IN
cord-006139-9063uhox	15	24	the	the	DT
cord-006139-9063uhox	15	25	host	host	NN
cord-006139-9063uhox	15	26	.	.	.
cord-006139-9063uhox	16	1	Large	large	JJ
cord-006139-9063uhox	16	2	-	-	HYPH
cord-006139-9063uhox	16	3	scale	scale	NN
cord-006139-9063uhox	16	4	deployment	deployment	NN
cord-006139-9063uhox	16	5	of	of	IN
cord-006139-9063uhox	16	6	bed	bed	NN
cord-006139-9063uhox	16	7	nets	net	NNS
cord-006139-9063uhox	16	8	[	[	-LRB-
cord-006139-9063uhox	16	9	3	3	CD
cord-006139-9063uhox	16	10	]	]	-RRB-
cord-006139-9063uhox	16	11	,	,	,
cord-006139-9063uhox	16	12	reintroduction	reintroduction	NN
cord-006139-9063uhox	16	13	of	of	IN
cord-006139-9063uhox	16	14	DDT	DDT	NNP
cord-006139-9063uhox	16	15	in	in	IN
cord-006139-9063uhox	16	16	some	some	DT
cord-006139-9063uhox	16	17	areas	area	NNS
cord-006139-9063uhox	16	18	,	,	,
cord-006139-9063uhox	16	19	such	such	JJ
cord-006139-9063uhox	16	20	as	as	IN
cord-006139-9063uhox	16	21	Mozambique	Mozambique	NNP
cord-006139-9063uhox	16	22	[	[	-LRB-
cord-006139-9063uhox	16	23	4	4	CD
cord-006139-9063uhox	16	24	]	]	-RRB-
cord-006139-9063uhox	16	25	,	,	,
cord-006139-9063uhox	16	26	and	and	CC
cord-006139-9063uhox	16	27	the	the	DT
cord-006139-9063uhox	16	28	introduction	introduction	NN
cord-006139-9063uhox	16	29	of	of	IN
cord-006139-9063uhox	16	30	artemisinin	artemisinin	NN
cord-006139-9063uhox	16	31	combination	combination	NN
cord-006139-9063uhox	16	32	therapy	therapy	NN
cord-006139-9063uhox	16	33	(	(	-LRB-
cord-006139-9063uhox	16	34	ACT	ACT	NNP
cord-006139-9063uhox	16	35	)	)	-RRB-
cord-006139-9063uhox	16	36	have	have	VBP
cord-006139-9063uhox	16	37	all	all	RB
cord-006139-9063uhox	16	38	contributed	contribute	VBN
cord-006139-9063uhox	16	39	to	to	IN
cord-006139-9063uhox	16	40	the	the	DT
cord-006139-9063uhox	16	41	significant	significant	JJ
cord-006139-9063uhox	16	42	progress	progress	NN
cord-006139-9063uhox	16	43	made	make	VBN
cord-006139-9063uhox	16	44	in	in	IN
cord-006139-9063uhox	16	45	the	the	DT
cord-006139-9063uhox	16	46	last	last	JJ
cord-006139-9063uhox	16	47	decade	decade	NN
cord-006139-9063uhox	16	48	in	in	IN
cord-006139-9063uhox	16	49	fighting	fight	VBG
cord-006139-9063uhox	16	50	malaria	malaria	NN
cord-006139-9063uhox	16	51	[	[	-LRB-
cord-006139-9063uhox	16	52	5	5	CD
cord-006139-9063uhox	16	53	]	]	-RRB-
cord-006139-9063uhox	16	54	.	.	.
cord-006139-9063uhox	17	1	Drug	drug	NN
cord-006139-9063uhox	17	2	resistance	resistance	NN
cord-006139-9063uhox	17	3	:	:	:
cord-006139-9063uhox	17	4	an	an	DT
cord-006139-9063uhox	17	5	ominous	ominous	JJ
cord-006139-9063uhox	17	6	threat	threat	NN
cord-006139-9063uhox	18	1	The	the	DT
cord-006139-9063uhox	18	2	first	first	JJ
cord-006139-9063uhox	18	3	highly	highly	RB
cord-006139-9063uhox	18	4	active	active	JJ
cord-006139-9063uhox	18	5	synthetic	synthetic	JJ
cord-006139-9063uhox	18	6	antimalarials	antimalarial	NNS
cord-006139-9063uhox	18	7	introduced	introduce	VBN
cord-006139-9063uhox	18	8	after	after	IN
cord-006139-9063uhox	18	9	World	World	NNP
cord-006139-9063uhox	18	10	War	War	NNP
cord-006139-9063uhox	18	11	II	II	NNP
cord-006139-9063uhox	18	12	were	be	VBD
cord-006139-9063uhox	18	13	used	use	VBN
cord-006139-9063uhox	18	14	either	either	CC
cord-006139-9063uhox	18	15	as	as	IN
cord-006139-9063uhox	18	16	monotherapies	monotherapie	NNS
cord-006139-9063uhox	18	17	(	(	-LRB-
cord-006139-9063uhox	18	18	e.g.	e.g.	RB
cord-006139-9063uhox	18	19	,	,	,
cord-006139-9063uhox	18	20	chloroquine	chloroquine	NN
cord-006139-9063uhox	18	21	)	)	-RRB-
cord-006139-9063uhox	18	22	or	or	CC
cord-006139-9063uhox	18	23	combinations	combination	NNS
cord-006139-9063uhox	18	24	targeting	target	VBG
cord-006139-9063uhox	18	25	a	a	DT
cord-006139-9063uhox	18	26	single	single	JJ
cord-006139-9063uhox	18	27	pathway	pathway	NN
cord-006139-9063uhox	18	28	(	(	-LRB-
cord-006139-9063uhox	18	29	antifolates	antifolate	NNS
cord-006139-9063uhox	18	30	;	;	,
cord-006139-9063uhox	18	31	e.g.	e.g.	RB
cord-006139-9063uhox	18	32	,	,	,
cord-006139-9063uhox	18	33	sulfadoxine	sulfadoxine	NN
cord-006139-9063uhox	18	34	with	with	IN
cord-006139-9063uhox	18	35	pyrimethamine	pyrimethamine	NNP
cord-006139-9063uhox	18	36	)	)	-RRB-
cord-006139-9063uhox	18	37	.	.	.
cord-006139-9063uhox	19	1	This	this	DT
cord-006139-9063uhox	19	2	strategy	strategy	NN
cord-006139-9063uhox	19	3	eventually	eventually	RB
cord-006139-9063uhox	19	4	led	lead	VBD
cord-006139-9063uhox	19	5	to	to	IN
cord-006139-9063uhox	19	6	the	the	DT
cord-006139-9063uhox	19	7	emergence	emergence	NN
cord-006139-9063uhox	19	8	and	and	CC
cord-006139-9063uhox	19	9	widespread	widespread	JJ
cord-006139-9063uhox	19	10	dissemination	dissemination	NN
cord-006139-9063uhox	19	11	of	of	IN
cord-006139-9063uhox	19	12	drug	drug	NN
cord-006139-9063uhox	19	13	-	-	HYPH
cord-006139-9063uhox	19	14	resistant	resistant	JJ
cord-006139-9063uhox	19	15	parasites	parasite	NNS
cord-006139-9063uhox	19	16	.	.	.
cord-006139-9063uhox	20	1	Consequently	consequently	RB
cord-006139-9063uhox	20	2	,	,	,
cord-006139-9063uhox	20	3	starting	start	VBG
cord-006139-9063uhox	20	4	in	in	IN
cord-006139-9063uhox	20	5	the	the	DT
cord-006139-9063uhox	20	6	1990s	1990	NNS
cord-006139-9063uhox	20	7	,	,	,
cord-006139-9063uhox	20	8	new	new	JJ
cord-006139-9063uhox	20	9	combination	combination	NN
cord-006139-9063uhox	20	10	therapies	therapy	NNS
cord-006139-9063uhox	20	11	in	in	IN
cord-006139-9063uhox	20	12	the	the	DT
cord-006139-9063uhox	20	13	form	form	NN
cord-006139-9063uhox	20	14	of	of	IN
cord-006139-9063uhox	20	15	ACTs	act	NNS
cord-006139-9063uhox	20	16	were	be	VBD
cord-006139-9063uhox	20	17	introduced	introduce	VBN
cord-006139-9063uhox	20	18	.	.	.
cord-006139-9063uhox	21	1	These	these	DT
cord-006139-9063uhox	21	2	consist	consist	VBP
cord-006139-9063uhox	21	3	of	of	IN
cord-006139-9063uhox	21	4	an	an	DT
cord-006139-9063uhox	21	5	artemisinin	artemisinin	NN
cord-006139-9063uhox	21	6	derivative	derivative	JJ
cord-006139-9063uhox	21	7	,	,	,
cord-006139-9063uhox	21	8	such	such	JJ
cord-006139-9063uhox	21	9	as	as	IN
cord-006139-9063uhox	21	10	artesunate	artesunate	NNP
cord-006139-9063uhox	21	11	,	,	,
cord-006139-9063uhox	21	12	artemether	artemether	NNP
cord-006139-9063uhox	21	13	or	or	CC
cord-006139-9063uhox	21	14	dihydroartemisinin	dihydroartemisinin	NNP
cord-006139-9063uhox	21	15	on	on	IN
cord-006139-9063uhox	21	16	the	the	DT
cord-006139-9063uhox	21	17	one	one	CD
cord-006139-9063uhox	21	18	hand	hand	NN
cord-006139-9063uhox	21	19	,	,	,
cord-006139-9063uhox	21	20	combined	combine	VBN
cord-006139-9063uhox	21	21	in	in	IN
cord-006139-9063uhox	21	22	a	a	DT
cord-006139-9063uhox	21	23	fixed	fixed	JJ
cord-006139-9063uhox	21	24	dose	dose	NN
cord-006139-9063uhox	21	25	with	with	IN
cord-006139-9063uhox	21	26	a	a	DT
cord-006139-9063uhox	21	27	4-aminoquinoline	4-aminoquinoline	CD
cord-006139-9063uhox	21	28	,	,	,
cord-006139-9063uhox	21	29	aryl	aryl	NN
cord-006139-9063uhox	21	30	methanol	methanol	NN
cord-006139-9063uhox	21	31	or	or	CC
cord-006139-9063uhox	21	32	a	a	DT
cord-006139-9063uhox	21	33	related	related	JJ
cord-006139-9063uhox	21	34	derivative	derivative	NN
cord-006139-9063uhox	21	35	such	such	JJ
cord-006139-9063uhox	21	36	as	as	IN
cord-006139-9063uhox	21	37	amodiaquine	amodiaquine	NNP
cord-006139-9063uhox	21	38	,	,	,
cord-006139-9063uhox	21	39	lumefantrine	lumefantrine	NNP
cord-006139-9063uhox	21	40	(	(	-LRB-
cord-006139-9063uhox	21	41	Coartem	Coartem	NNP
cord-006139-9063uhox	21	42	®	®	VBP
cord-006139-9063uhox	21	43	,	,	,
cord-006139-9063uhox	21	44	Norvatis	Norvatis	NNP
cord-006139-9063uhox	21	45	,	,	,
cord-006139-9063uhox	21	46	Switzerland	Switzerland	NNP
cord-006139-9063uhox	21	47	)	)	-RRB-
cord-006139-9063uhox	21	48	,	,	,
cord-006139-9063uhox	21	49	mefloquine	mefloquine	FW
cord-006139-9063uhox	21	50	,	,	,
cord-006139-9063uhox	21	51	piperaquine	piperaquine	JJ
cord-006139-9063uhox	21	52	(	(	-LRB-
cord-006139-9063uhox	21	53	Euartesim	Euartesim	NNP
cord-006139-9063uhox	21	54	®	®	NNP
cord-006139-9063uhox	21	55	,	,	,
cord-006139-9063uhox	21	56	MMV	MMV	NNP
cord-006139-9063uhox	21	57	,	,	,
cord-006139-9063uhox	21	58	Switzerland	Switzerland	NNP
cord-006139-9063uhox	21	59	)	)	-RRB-
cord-006139-9063uhox	21	60	or	or	CC
cord-006139-9063uhox	21	61	pyronaridine	pyronaridine	NN
cord-006139-9063uhox	21	62	(	(	-LRB-
cord-006139-9063uhox	21	63	Pyramax	Pyramax	NNP
cord-006139-9063uhox	21	64	®	®	VBP
cord-006139-9063uhox	21	65	,	,	,
cord-006139-9063uhox	21	66	MMV	MMV	NNP
cord-006139-9063uhox	21	67	)	)	-RRB-
cord-006139-9063uhox	21	68	on	on	IN
cord-006139-9063uhox	21	69	the	the	DT
cord-006139-9063uhox	21	70	other	other	JJ
cord-006139-9063uhox	21	71	.	.	.
cord-006139-9063uhox	22	1	Currently	currently	RB
cord-006139-9063uhox	22	2	,	,	,
cord-006139-9063uhox	22	3	these	these	DT
cord-006139-9063uhox	22	4	ACTs	act	NNS
cord-006139-9063uhox	22	5	are	be	VBP
cord-006139-9063uhox	22	6	highly	highly	RB
cord-006139-9063uhox	22	7	effective	effective	JJ
cord-006139-9063uhox	22	8	.	.	.
cord-006139-9063uhox	23	1	However	however	RB
cord-006139-9063uhox	23	2	,	,	,
cord-006139-9063uhox	23	3	ominous	ominous	JJ
cord-006139-9063uhox	23	4	first	first	JJ
cord-006139-9063uhox	23	5	signs	sign	NNS
cord-006139-9063uhox	23	6	of	of	IN
cord-006139-9063uhox	23	7	possible	possible	JJ
cord-006139-9063uhox	23	8	future	future	JJ
cord-006139-9063uhox	23	9	resistance	resistance	NN
cord-006139-9063uhox	23	10	have	have	VBP
cord-006139-9063uhox	23	11	begun	begin	VBN
cord-006139-9063uhox	23	12	to	to	TO
cord-006139-9063uhox	23	13	appear	appear	VB
cord-006139-9063uhox	23	14	.	.	.
cord-006139-9063uhox	24	1	Patients	patient	NNS
cord-006139-9063uhox	24	2	have	have	VBP
cord-006139-9063uhox	24	3	been	be	VBN
cord-006139-9063uhox	24	4	identified	identify	VBN
cord-006139-9063uhox	24	5	with	with	IN
cord-006139-9063uhox	24	6	prolonged	prolong	VBN
cord-006139-9063uhox	24	7	parasite	parasite	NN
cord-006139-9063uhox	24	8	clearance	clearance	NN
cord-006139-9063uhox	24	9	times	time	NNS
cord-006139-9063uhox	24	10	,	,	,
cord-006139-9063uhox	24	11	resulting	result	VBG
cord-006139-9063uhox	24	12	in	in	IN
cord-006139-9063uhox	24	13	artemisinin	artemisinin	NN
cord-006139-9063uhox	24	14	treatment	treatment	NN
cord-006139-9063uhox	24	15	failures	failure	NNS
cord-006139-9063uhox	24	16	in	in	IN
cord-006139-9063uhox	24	17	western	western	JJ
cord-006139-9063uhox	24	18	Cambodia	Cambodia	NNP
cord-006139-9063uhox	24	19	and	and	CC
cord-006139-9063uhox	24	20	western	western	JJ
cord-006139-9063uhox	24	21	Thailand	Thailand	NNP
cord-006139-9063uhox	24	22	[	[	-LRB-
cord-006139-9063uhox	24	23	6	6	CD
cord-006139-9063uhox	24	24	]	]	-RRB-
cord-006139-9063uhox	24	25	[	[	-LRB-
cord-006139-9063uhox	24	26	7	7	CD
cord-006139-9063uhox	24	27	]	]	-RRB-
cord-006139-9063uhox	24	28	[	[	-LRB-
cord-006139-9063uhox	24	29	8	8	CD
cord-006139-9063uhox	24	30	]	]	-RRB-
cord-006139-9063uhox	24	31	.	.	.
cord-006139-9063uhox	25	1	This	this	DT
cord-006139-9063uhox	25	2	appears	appear	VBZ
cord-006139-9063uhox	25	3	to	to	TO
cord-006139-9063uhox	25	4	have	have	VB
cord-006139-9063uhox	25	5	occurred	occur	VBN
cord-006139-9063uhox	25	6	as	as	IN
cord-006139-9063uhox	25	7	a	a	DT
cord-006139-9063uhox	25	8	result	result	NN
cord-006139-9063uhox	25	9	of	of	IN
cord-006139-9063uhox	25	10	the	the	DT
cord-006139-9063uhox	25	11	use	use	NN
cord-006139-9063uhox	25	12	of	of	IN
cord-006139-9063uhox	25	13	artemisinin	artemisinin	NN
cord-006139-9063uhox	25	14	monotherapy	monotherapy	NN
cord-006139-9063uhox	25	15	[	[	-LRB-
cord-006139-9063uhox	25	16	6	6	CD
cord-006139-9063uhox	25	17	]	]	-RRB-
cord-006139-9063uhox	25	18	.	.	.
cord-006139-9063uhox	26	1	At	at	IN
cord-006139-9063uhox	26	2	the	the	DT
cord-006139-9063uhox	26	3	same	same	JJ
cord-006139-9063uhox	26	4	time	time	NN
cord-006139-9063uhox	26	5	,	,	,
cord-006139-9063uhox	26	6	resistance	resistance	NN
cord-006139-9063uhox	26	7	to	to	IN
cord-006139-9063uhox	26	8	mefloquine	mefloquine	NNP
cord-006139-9063uhox	26	9	is	be	VBZ
cord-006139-9063uhox	26	10	widespread	widespread	JJ
cord-006139-9063uhox	26	11	[	[	-LRB-
cord-006139-9063uhox	26	12	9	9	CD
cord-006139-9063uhox	26	13	]	]	-RRB-
cord-006139-9063uhox	26	14	,	,	,
cord-006139-9063uhox	26	15	while	while	IN
cord-006139-9063uhox	26	16	some	some	DT
cord-006139-9063uhox	26	17	strains	strain	NNS
cord-006139-9063uhox	26	18	of	of	IN
cord-006139-9063uhox	26	19	chloroquine	chloroquine	NN
cord-006139-9063uhox	26	20	-	-	HYPH
cord-006139-9063uhox	26	21	resistant	resistant	JJ
cord-006139-9063uhox	26	22	parasite	parasite	NN
cord-006139-9063uhox	26	23	are	be	VBP
cord-006139-9063uhox	26	24	also	also	RB
cord-006139-9063uhox	26	25	cross	cross	JJ
cord-006139-9063uhox	26	26	-	-	JJ
cord-006139-9063uhox	26	27	resistant	resistant	JJ
cord-006139-9063uhox	26	28	to	to	IN
cord-006139-9063uhox	26	29	amodiaquine	amodiaquine	NNP
cord-006139-9063uhox	26	30	[	[	-LRB-
cord-006139-9063uhox	26	31	10	10	CD
cord-006139-9063uhox	26	32	]	]	-RRB-
cord-006139-9063uhox	26	33	.	.	.
cord-006139-9063uhox	27	1	In	in	IN
cord-006139-9063uhox	27	2	addition	addition	NN
cord-006139-9063uhox	27	3	,	,	,
cord-006139-9063uhox	27	4	evidence	evidence	NN
cord-006139-9063uhox	27	5	suggestive	suggestive	JJ
cord-006139-9063uhox	27	6	of	of	IN
cord-006139-9063uhox	27	7	the	the	DT
cord-006139-9063uhox	27	8	possible	possible	JJ
cord-006139-9063uhox	27	9	development	development	NN
cord-006139-9063uhox	27	10	of	of	IN
cord-006139-9063uhox	27	11	lumefantrine	lumefantrine	NNP
cord-006139-9063uhox	27	12	tolerance	tolerance	NN
cord-006139-9063uhox	27	13	,	,	,
cord-006139-9063uhox	27	14	which	which	WDT
cord-006139-9063uhox	27	15	is	be	VBZ
cord-006139-9063uhox	27	16	the	the	DT
cord-006139-9063uhox	27	17	first	first	JJ
cord-006139-9063uhox	27	18	step	step	NN
cord-006139-9063uhox	27	19	towards	towards	IN
cord-006139-9063uhox	27	20	resistance	resistance	NN
cord-006139-9063uhox	27	21	,	,	,
cord-006139-9063uhox	27	22	has	have	VBZ
cord-006139-9063uhox	27	23	begun	begin	VBN
cord-006139-9063uhox	27	24	to	to	TO
cord-006139-9063uhox	27	25	emerge	emerge	VB
cord-006139-9063uhox	27	26	in	in	IN
cord-006139-9063uhox	27	27	east	east	NN
cord-006139-9063uhox	27	28	Africa	Africa	NNP
cord-006139-9063uhox	27	29	,	,	,
cord-006139-9063uhox	27	30	where	where	WRB
cord-006139-9063uhox	27	31	Coartem	Coartem	NNP
cord-006139-9063uhox	27	32	is	be	VBZ
cord-006139-9063uhox	27	33	widely	widely	RB
cord-006139-9063uhox	27	34	used	use	VBN
cord-006139-9063uhox	27	35	[	[	-LRB-
cord-006139-9063uhox	27	36	11	11	CD
cord-006139-9063uhox	27	37	]	]	-RRB-
cord-006139-9063uhox	27	38	.	.	.
cord-006139-9063uhox	28	1	While	while	IN
cord-006139-9063uhox	28	2	resistance	resistance	NN
cord-006139-9063uhox	28	3	to	to	IN
cord-006139-9063uhox	28	4	ACT	ACT	NNP
cord-006139-9063uhox	28	5	may	may	MD
cord-006139-9063uhox	28	6	still	still	RB
cord-006139-9063uhox	28	7	be	be	VB
cord-006139-9063uhox	28	8	some	some	DT
cord-006139-9063uhox	28	9	time	time	NN
cord-006139-9063uhox	28	10	away	away	RB
cord-006139-9063uhox	28	11	,	,	,
cord-006139-9063uhox	28	12	it	-PRON-	PRP
cord-006139-9063uhox	28	13	is	be	VBZ
cord-006139-9063uhox	28	14	prudent	prudent	JJ
cord-006139-9063uhox	28	15	that	that	IN
cord-006139-9063uhox	28	16	new	new	JJ
cord-006139-9063uhox	28	17	antimalarials	antimalarial	NNS
cord-006139-9063uhox	28	18	be	be	VB
cord-006139-9063uhox	28	19	developed	develop	VBN
cord-006139-9063uhox	28	20	against	against	IN
cord-006139-9063uhox	28	21	this	this	DT
cord-006139-9063uhox	28	22	possibility	possibility	NN
cord-006139-9063uhox	28	23	.	.	.
cord-006139-9063uhox	29	1	Thus	thus	RB
cord-006139-9063uhox	29	2	,	,	,
cord-006139-9063uhox	29	3	considerable	considerable	JJ
cord-006139-9063uhox	29	4	work	work	NN
cord-006139-9063uhox	29	5	continues	continue	VBZ
cord-006139-9063uhox	29	6	to	to	TO
cord-006139-9063uhox	29	7	find	find	VB
cord-006139-9063uhox	29	8	new	new	JJ
cord-006139-9063uhox	29	9	and	and	CC
cord-006139-9063uhox	29	10	improved	improved	JJ
cord-006139-9063uhox	29	11	antimalarials	antimalarial	NNS
cord-006139-9063uhox	29	12	.	.	.
cord-006139-9063uhox	30	1	future	future	JJ
cord-006139-9063uhox	30	2	science	science	NN
cord-006139-9063uhox	30	3	group	group	NN
cord-006139-9063uhox	30	4	important	important	JJ
cord-006139-9063uhox	30	5	.	.	.
cord-006139-9063uhox	31	1	Prior	prior	RB
cord-006139-9063uhox	31	2	to	to	IN
cord-006139-9063uhox	31	3	the	the	DT
cord-006139-9063uhox	31	4	emergence	emergence	NN
cord-006139-9063uhox	31	5	of	of	IN
cord-006139-9063uhox	31	6	resistance	resistance	NN
cord-006139-9063uhox	31	7	,	,	,
cord-006139-9063uhox	31	8	it	-PRON-	PRP
cord-006139-9063uhox	31	9	was	be	VBD
cord-006139-9063uhox	31	10	highly	highly	RB
cord-006139-9063uhox	31	11	effective	effective	JJ
cord-006139-9063uhox	31	12	,	,	,
cord-006139-9063uhox	31	13	generally	generally	RB
cord-006139-9063uhox	31	14	well	well	RB
cord-006139-9063uhox	31	15	tolerated	tolerate	VBN
cord-006139-9063uhox	31	16	at	at	IN
cord-006139-9063uhox	31	17	appropriate	appropriate	JJ
cord-006139-9063uhox	31	18	doses	dose	NNS
cord-006139-9063uhox	31	19	,	,	,
cord-006139-9063uhox	31	20	safe	safe	JJ
cord-006139-9063uhox	31	21	for	for	IN
cord-006139-9063uhox	31	22	use	use	NN
cord-006139-9063uhox	31	23	in	in	IN
cord-006139-9063uhox	31	24	pregnancy	pregnancy	NN
cord-006139-9063uhox	31	25	and	and	CC
cord-006139-9063uhox	31	26	inexpensive	inexpensive	JJ
cord-006139-9063uhox	31	27	.	.	.
cord-006139-9063uhox	32	1	Unfortunately	unfortunately	RB
cord-006139-9063uhox	32	2	,	,	,
cord-006139-9063uhox	32	3	chloroquineresistant	chloroquineresistant	NN
cord-006139-9063uhox	32	4	P.	p.	NN
cord-006139-9063uhox	32	5	falciparum	falciparum	NN
cord-006139-9063uhox	32	6	is	be	VBZ
cord-006139-9063uhox	32	7	now	now	RB
cord-006139-9063uhox	32	8	very	very	RB
cord-006139-9063uhox	32	9	widespread	widespread	JJ
cord-006139-9063uhox	32	10	.	.	.
cord-006139-9063uhox	33	1	Nonetheless	nonetheless	RB
cord-006139-9063uhox	33	2	,	,	,
cord-006139-9063uhox	33	3	this	this	DT
cord-006139-9063uhox	33	4	has	have	VBZ
cord-006139-9063uhox	33	5	not	not	RB
cord-006139-9063uhox	33	6	led	lead	VBN
cord-006139-9063uhox	33	7	to	to	IN
cord-006139-9063uhox	33	8	the	the	DT
cord-006139-9063uhox	33	9	complete	complete	JJ
cord-006139-9063uhox	33	10	loss	loss	NN
cord-006139-9063uhox	33	11	of	of	IN
cord-006139-9063uhox	33	12	this	this	DT
cord-006139-9063uhox	33	13	class	class	NN
cord-006139-9063uhox	33	14	of	of	IN
cord-006139-9063uhox	33	15	compound	compound	NN
cord-006139-9063uhox	33	16	,	,	,
cord-006139-9063uhox	33	17	because	because	IN
cord-006139-9063uhox	33	18	resistance	resistance	NN
cord-006139-9063uhox	33	19	is	be	VBZ
cord-006139-9063uhox	33	20	not	not	RB
cord-006139-9063uhox	33	21	coupled	couple	VBN
cord-006139-9063uhox	33	22	to	to	IN
cord-006139-9063uhox	33	23	the	the	DT
cord-006139-9063uhox	33	24	drug	drug	NN
cord-006139-9063uhox	33	25	target	target	NN
cord-006139-9063uhox	33	26	itself	-PRON-	PRP
cord-006139-9063uhox	33	27	.	.	.
cord-006139-9063uhox	34	1	Indeed	indeed	RB
cord-006139-9063uhox	34	2	,	,	,
cord-006139-9063uhox	34	3	the	the	DT
cord-006139-9063uhox	34	4	4-aminoquinoline	4-aminoquinoline	CD
cord-006139-9063uhox	34	5	piperaquine	piperaquine	NN
cord-006139-9063uhox	34	6	has	have	VBZ
cord-006139-9063uhox	34	7	recently	recently	RB
cord-006139-9063uhox	34	8	entered	enter	VBN
cord-006139-9063uhox	34	9	the	the	DT
cord-006139-9063uhox	34	10	clinic	clinic	NN
cord-006139-9063uhox	34	11	(	(	-LRB-
cord-006139-9063uhox	34	12	in	in	IN
cord-006139-9063uhox	34	13	combination	combination	NN
cord-006139-9063uhox	34	14	with	with	IN
cord-006139-9063uhox	34	15	dihydroartemisinin	dihydroartemisinin	NNP
cord-006139-9063uhox	34	16	)	)	-RRB-
cord-006139-9063uhox	34	17	[	[	-LRB-
cord-006139-9063uhox	34	18	12	12	CD
cord-006139-9063uhox	34	19	]	]	-RRB-
cord-006139-9063uhox	34	20	,	,	,
cord-006139-9063uhox	34	21	while	while	IN
cord-006139-9063uhox	34	22	another	another	DT
cord-006139-9063uhox	34	23	4-aminoquinoline	4-aminoquinoline	CD
cord-006139-9063uhox	34	24	,	,	,
cord-006139-9063uhox	34	25	ferroquine	ferroquine	NN
cord-006139-9063uhox	34	26	,	,	,
cord-006139-9063uhox	34	27	is	be	VBZ
cord-006139-9063uhox	34	28	in	in	IN
cord-006139-9063uhox	34	29	Phase	phase	NN
cord-006139-9063uhox	34	30	IIb	iib	JJ
cord-006139-9063uhox	34	31	clinical	clinical	JJ
cord-006139-9063uhox	34	32	trials	trial	NNS
cord-006139-9063uhox	34	33	[	[	-LRB-
cord-006139-9063uhox	34	34	13	13	CD
cord-006139-9063uhox	34	35	]	]	-RRB-
cord-006139-9063uhox	34	36	.	.	.
cord-006139-9063uhox	35	1	In	in	IN
cord-006139-9063uhox	35	2	addition	addition	NN
cord-006139-9063uhox	35	3	,	,	,
cord-006139-9063uhox	35	4	the	the	DT
cord-006139-9063uhox	35	5	4-aminoquinoline	4-aminoquinoline	CD
cord-006139-9063uhox	35	6	,	,	,
cord-006139-9063uhox	35	7	amodiaquine	amodiaquine	NNP
cord-006139-9063uhox	35	8	,	,	,
cord-006139-9063uhox	35	9	and	and	CC
cord-006139-9063uhox	35	10	the	the	DT
cord-006139-9063uhox	35	11	quinoline	quinoline	NN
cord-006139-9063uhox	35	12	methanol	methanol	NN
cord-006139-9063uhox	35	13	,	,	,
cord-006139-9063uhox	35	14	mefloquine	mefloquine	FW
cord-006139-9063uhox	35	15	,	,	,
cord-006139-9063uhox	35	16	as	as	RB
cord-006139-9063uhox	35	17	well	well	RB
cord-006139-9063uhox	35	18	as	as	IN
cord-006139-9063uhox	35	19	the	the	DT
cord-006139-9063uhox	35	20	aryl	aryl	NNP
cord-006139-9063uhox	35	21	methanol	methanol	NN
cord-006139-9063uhox	35	22	,	,	,
cord-006139-9063uhox	35	23	lumefantrine	lumefantrine	NNP
cord-006139-9063uhox	35	24	,	,	,
cord-006139-9063uhox	35	25	are	be	VBP
cord-006139-9063uhox	35	26	all	all	DT
cord-006139-9063uhox	35	27	currently	currently	RB
cord-006139-9063uhox	35	28	crucial	crucial	JJ
cord-006139-9063uhox	35	29	components	component	NNS
cord-006139-9063uhox	35	30	of	of	IN
cord-006139-9063uhox	35	31	ACT	ACT	NNP
cord-006139-9063uhox	35	32	.	.	.
cord-006139-9063uhox	36	1	These	these	DT
cord-006139-9063uhox	36	2	antimalarials	antimalarial	NNS
cord-006139-9063uhox	36	3	are	be	VBP
cord-006139-9063uhox	36	4	widely	widely	RB
cord-006139-9063uhox	36	5	believed	believe	VBN
cord-006139-9063uhox	36	6	to	to	TO
cord-006139-9063uhox	36	7	act	act	VB
cord-006139-9063uhox	36	8	by	by	IN
cord-006139-9063uhox	36	9	inhibiting	inhibit	VBG
cord-006139-9063uhox	36	10	heme	heme	JJ
cord-006139-9063uhox	36	11	detoxification	detoxification	NN
cord-006139-9063uhox	36	12	in	in	IN
cord-006139-9063uhox	36	13	the	the	DT
cord-006139-9063uhox	36	14	malaria	malaria	NN
cord-006139-9063uhox	36	15	parasite	parasite	NN
cord-006139-9063uhox	36	16	,	,	,
cord-006139-9063uhox	36	17	a	a	DT
cord-006139-9063uhox	36	18	hypothesis	hypothesis	NN
cord-006139-9063uhox	36	19	that	that	WDT
cord-006139-9063uhox	36	20	is	be	VBZ
cord-006139-9063uhox	36	21	best	well	RBS
cord-006139-9063uhox	36	22	established	establish	VBN
cord-006139-9063uhox	36	23	in	in	IN
cord-006139-9063uhox	36	24	the	the	DT
cord-006139-9063uhox	36	25	case	case	NN
cord-006139-9063uhox	36	26	of	of	IN
cord-006139-9063uhox	36	27	chloroquine	chloroquine	NN
cord-006139-9063uhox	36	28	.	.	.
cord-006139-9063uhox	37	1	The	the	DT
cord-006139-9063uhox	37	2	process	process	NN
cord-006139-9063uhox	37	3	of	of	IN
cord-006139-9063uhox	37	4	hemoglobin	hemoglobin	NN
cord-006139-9063uhox	37	5	digestion	digestion	NN
cord-006139-9063uhox	37	6	and	and	CC
cord-006139-9063uhox	37	7	heme	heme	NN
cord-006139-9063uhox	37	8	detoxification	detoxification	NN
cord-006139-9063uhox	37	9	is	be	VBZ
cord-006139-9063uhox	37	10	summarized	summarize	VBN
cord-006139-9063uhox	37	11	in	in	IN
cord-006139-9063uhox	37	12	Figure	Figure	NNP
cord-006139-9063uhox	37	13	1	1	CD
cord-006139-9063uhox	37	14	.	.	.
cord-006139-9063uhox	38	1	Hemozoin	Hemozoin	NNP
cord-006139-9063uhox	38	2	formation	formation	NN
cord-006139-9063uhox	38	3	is	be	VBZ
cord-006139-9063uhox	38	4	the	the	DT
cord-006139-9063uhox	38	5	dominant	dominant	JJ
cord-006139-9063uhox	38	6	fate	fate	NN
cord-006139-9063uhox	38	7	of	of	IN
cord-006139-9063uhox	38	8	heme	heme	NN
cord-006139-9063uhox	38	9	released	release	VBN
cord-006139-9063uhox	38	10	into	into	IN
cord-006139-9063uhox	38	11	the	the	DT
cord-006139-9063uhox	38	12	digestive	digestive	JJ
cord-006139-9063uhox	38	13	vacuole	vacuole	NN
cord-006139-9063uhox	38	14	(	(	-LRB-
cord-006139-9063uhox	38	15	DV	DV	NNP
cord-006139-9063uhox	38	16	)	)	-RRB-
cord-006139-9063uhox	38	17	,	,	,
cord-006139-9063uhox	38	18	with	with	IN
cord-006139-9063uhox	38	19	at	at	RB
cord-006139-9063uhox	38	20	least	least	RBS
cord-006139-9063uhox	38	21	95	95	CD
cord-006139-9063uhox	38	22	%	%	NN
cord-006139-9063uhox	38	23	of	of	IN
cord-006139-9063uhox	38	24	the	the	DT
cord-006139-9063uhox	38	25	iron	iron	NN
cord-006139-9063uhox	38	26	present	present	NN
cord-006139-9063uhox	38	27	in	in	IN
cord-006139-9063uhox	38	28	late	late	JJ
cord-006139-9063uhox	38	29	trophozoites	trophozoite	NNS
cord-006139-9063uhox	38	30	(	(	-LRB-
cord-006139-9063uhox	38	31	32	32	CD
cord-006139-9063uhox	38	32	h	h	NN
cord-006139-9063uhox	38	33	into	into	IN
cord-006139-9063uhox	38	34	the	the	DT
cord-006139-9063uhox	38	35	48-h	48-h	CD
cord-006139-9063uhox	38	36	blood	blood	NN
cord-006139-9063uhox	38	37	cycle	cycle	NN
cord-006139-9063uhox	38	38	)	)	-RRB-
cord-006139-9063uhox	38	39	present	present	JJ
cord-006139-9063uhox	38	40	as	as	IN
cord-006139-9063uhox	38	41	hemozoin	hemozoin	NNP
cord-006139-9063uhox	38	42	[	[	-LRB-
cord-006139-9063uhox	38	43	14	14	CD
cord-006139-9063uhox	38	44	]	]	-RRB-
cord-006139-9063uhox	38	45	.	.	.
cord-006139-9063uhox	39	1	The	the	DT
cord-006139-9063uhox	39	2	parasite	parasite	NN
cord-006139-9063uhox	39	3	also	also	RB
cord-006139-9063uhox	39	4	possesses	possess	VBZ
cord-006139-9063uhox	39	5	an	an	DT
cord-006139-9063uhox	39	6	endogenous	endogenous	JJ
cord-006139-9063uhox	39	7	cytosolic	cytosolic	JJ
cord-006139-9063uhox	39	8	Fe	fe	NN
cord-006139-9063uhox	39	9	-	-	HYPH
cord-006139-9063uhox	39	10	superoxide	superoxide	NN
cord-006139-9063uhox	39	11	dismutase	dismutase	NN
cord-006139-9063uhox	39	12	and	and	CC
cord-006139-9063uhox	39	13	imports	import	NNS
cord-006139-9063uhox	39	14	a	a	DT
cord-006139-9063uhox	39	15	host	host	NN
cord-006139-9063uhox	39	16	peroxiredoxin	peroxiredoxin	NN
cord-006139-9063uhox	39	17	from	from	IN
cord-006139-9063uhox	39	18	the	the	DT
cord-006139-9063uhox	39	19	red	red	JJ
cord-006139-9063uhox	39	20	blood	blood	NN
cord-006139-9063uhox	39	21	cell	cell	NN
cord-006139-9063uhox	39	22	into	into	IN
cord-006139-9063uhox	39	23	the	the	DT
cord-006139-9063uhox	39	24	parasite	parasite	NN
cord-006139-9063uhox	39	25	cytosol	cytosol	NN
cord-006139-9063uhox	39	26	[	[	-LRB-
cord-006139-9063uhox	39	27	15	15	CD
cord-006139-9063uhox	39	28	,	,	,
cord-006139-9063uhox	39	29	16	16	CD
cord-006139-9063uhox	39	30	]	]	-RRB-
cord-006139-9063uhox	39	31	.	.	.
cord-006139-9063uhox	40	1	These	these	DT
cord-006139-9063uhox	40	2	enzymes	enzyme	NNS
cord-006139-9063uhox	40	3	remove	remove	VBP
cord-006139-9063uhox	40	4	O	o	CD
cord-006139-9063uhox	40	5	2	2	CD
cord-006139-9063uhox	40	6	and	and	CC
cord-006139-9063uhox	40	7	H	h	NN
cord-006139-9063uhox	40	8	2	2	CD
cord-006139-9063uhox	40	9	O	o	NN
cord-006139-9063uhox	40	10	2	2	CD
cord-006139-9063uhox	40	11	,	,	,
cord-006139-9063uhox	40	12	both	both	DT
cord-006139-9063uhox	40	13	of	of	IN
cord-006139-9063uhox	40	14	which	which	WDT
cord-006139-9063uhox	40	15	are	be	VBP
cord-006139-9063uhox	40	16	probably	probably	RB
cord-006139-9063uhox	40	17	produced	produce	VBN
cord-006139-9063uhox	40	18	in	in	IN
cord-006139-9063uhox	40	19	part	part	NN
cord-006139-9063uhox	40	20	during	during	IN
cord-006139-9063uhox	40	21	the	the	DT
cord-006139-9063uhox	40	22	oxidation	oxidation	NN
cord-006139-9063uhox	40	23	of	of	IN
cord-006139-9063uhox	40	24	Fe(II)heme	Fe(II)heme	NNP
cord-006139-9063uhox	40	25	.	.	.
cord-006139-9063uhox	41	1	While	while	IN
cord-006139-9063uhox	41	2	it	-PRON-	PRP
cord-006139-9063uhox	41	3	has	have	VBZ
cord-006139-9063uhox	41	4	long	long	RB
cord-006139-9063uhox	41	5	been	be	VBN
cord-006139-9063uhox	41	6	known	know	VBN
cord-006139-9063uhox	41	7	that	that	IN
cord-006139-9063uhox	41	8	antimalarials	antimalarial	NNS
cord-006139-9063uhox	41	9	such	such	JJ
cord-006139-9063uhox	41	10	as	as	IN
cord-006139-9063uhox	41	11	chloroquine	chloroquine	NN
cord-006139-9063uhox	41	12	and	and	CC
cord-006139-9063uhox	41	13	quinine	quinine	NN
cord-006139-9063uhox	41	14	interact	interact	VBP
cord-006139-9063uhox	41	15	directly	directly	RB
cord-006139-9063uhox	41	16	with	with	IN
cord-006139-9063uhox	41	17	Fe(III)heme	Fe(III)heme	NNP
cord-006139-9063uhox	41	18	[	[	-LRB-
cord-006139-9063uhox	41	19	17	17	CD
cord-006139-9063uhox	41	20	,	,	,
cord-006139-9063uhox	41	21	18	18	CD
cord-006139-9063uhox	41	22	]	]	-RRB-
cord-006139-9063uhox	41	23	,	,	,
cord-006139-9063uhox	41	24	the	the	DT
cord-006139-9063uhox	41	25	first	first	JJ
cord-006139-9063uhox	41	26	crystal	crystal	NN
cord-006139-9063uhox	41	27	structure	structure	NN
cord-006139-9063uhox	41	28	of	of	IN
cord-006139-9063uhox	41	29	a	a	DT
cord-006139-9063uhox	41	30	drug	drug	NN
cord-006139-9063uhox	41	31	-	-	HYPH
cord-006139-9063uhox	41	32	Fe(III)heme	fe(iii)heme	NN
cord-006139-9063uhox	41	33	complex	complex	NN
cord-006139-9063uhox	41	34	(	(	-LRB-
cord-006139-9063uhox	41	35	that	that	DT
cord-006139-9063uhox	41	36	of	of	IN
cord-006139-9063uhox	41	37	halofantrine	halofantrine	NN
cord-006139-9063uhox	41	38	-	-	HYPH
cord-006139-9063uhox	41	39	Fe[III]heme	Fe[III]heme	NNP
cord-006139-9063uhox	41	40	)	)	-RRB-
cord-006139-9063uhox	41	41	,	,	,
cord-006139-9063uhox	41	42	was	be	VBD
cord-006139-9063uhox	41	43	only	only	RB
cord-006139-9063uhox	41	44	reported	report	VBN
cord-006139-9063uhox	41	45	in	in	IN
cord-006139-9063uhox	41	46	2008	2008	CD
cord-006139-9063uhox	42	1	(	(	-LRB-
cord-006139-9063uhox	42	2	Figure	figure	NN
cord-006139-9063uhox	42	3	2A	2a	CD
cord-006139-9063uhox	42	4	)	)	-RRB-
cord-006139-9063uhox	42	5	Figure	figure	NN
cord-006139-9063uhox	42	6	1	1	CD
cord-006139-9063uhox	42	7	.	.	.
cord-006139-9063uhox	43	1	A	a	DT
cord-006139-9063uhox	43	2	schematic	schematic	JJ
cord-006139-9063uhox	43	3	representation	representation	NN
cord-006139-9063uhox	43	4	of	of	IN
cord-006139-9063uhox	43	5	the	the	DT
cord-006139-9063uhox	43	6	process	process	NN
cord-006139-9063uhox	43	7	of	of	IN
cord-006139-9063uhox	43	8	hemoglobin	hemoglobin	NN
cord-006139-9063uhox	43	9	degradation	degradation	NN
cord-006139-9063uhox	43	10	and	and	CC
cord-006139-9063uhox	43	11	hemozoin	hemozoin	NNP
cord-006139-9063uhox	43	12	formation	formation	NN
cord-006139-9063uhox	43	13	in	in	IN
cord-006139-9063uhox	43	14	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	43	15	falciparum	falciparum	NN
cord-006139-9063uhox	43	16	.	.	.
cord-006139-9063uhox	44	1	RBC	RBC	NNP
cord-006139-9063uhox	44	2	cytoplasm	cytoplasm	NN
cord-006139-9063uhox	44	3	is	be	VBZ
cord-006139-9063uhox	44	4	taken	take	VBN
cord-006139-9063uhox	44	5	up	up	RP
cord-006139-9063uhox	44	6	into	into	IN
cord-006139-9063uhox	44	7	the	the	DT
cord-006139-9063uhox	44	8	malaria	malaria	NN
cord-006139-9063uhox	44	9	parasite	parasite	NN
cord-006139-9063uhox	44	10	via	via	IN
cord-006139-9063uhox	44	11	transport	transport	NN
cord-006139-9063uhox	44	12	vesicles	vesicle	NNS
cord-006139-9063uhox	44	13	in	in	IN
cord-006139-9063uhox	44	14	an	an	DT
cord-006139-9063uhox	44	15	endocytotic	endocytotic	JJ
cord-006139-9063uhox	44	16	process	process	NN
cord-006139-9063uhox	44	17	and	and	CC
cord-006139-9063uhox	44	18	delivered	deliver	VBN
cord-006139-9063uhox	44	19	to	to	IN
cord-006139-9063uhox	44	20	the	the	DT
cord-006139-9063uhox	44	21	acidic	acidic	JJ
cord-006139-9063uhox	44	22	digestive	digestive	JJ
cord-006139-9063uhox	44	23	vacuole	vacuole	NN
cord-006139-9063uhox	44	24	(	(	-LRB-
cord-006139-9063uhox	44	25	~pH5	~pH5	NFP
cord-006139-9063uhox	44	26	)	)	-RRB-
cord-006139-9063uhox	45	1	[	[	-LRB-
cord-006139-9063uhox	45	2	86	86	CD
cord-006139-9063uhox	45	3	]	]	-RRB-
cord-006139-9063uhox	45	4	.	.	.
cord-006139-9063uhox	46	1	Hemoglobin	hemoglobin	NN
cord-006139-9063uhox	46	2	is	be	VBZ
cord-006139-9063uhox	46	3	digested	digest	VBN
cord-006139-9063uhox	46	4	by	by	IN
cord-006139-9063uhox	46	5	a	a	DT
cord-006139-9063uhox	46	6	series	series	NN
cord-006139-9063uhox	46	7	of	of	IN
cord-006139-9063uhox	46	8	proteases	protease	NNS
cord-006139-9063uhox	46	9	:	:	:
cord-006139-9063uhox	46	10	plasmepsins	plasmepsin	NNS
cord-006139-9063uhox	46	11	,	,	,
cord-006139-9063uhox	46	12	HAP	HAP	NNP
cord-006139-9063uhox	46	13	,	,	,
cord-006139-9063uhox	46	14	falcipains	falcipain	NNS
cord-006139-9063uhox	46	15	and	and	CC
cord-006139-9063uhox	46	16	falcilysin	falcilysin	NNP
cord-006139-9063uhox	46	17	[	[	-LRB-
cord-006139-9063uhox	46	18	87	87	CD
cord-006139-9063uhox	46	19	]	]	-RRB-
cord-006139-9063uhox	46	20	[	[	-LRB-
cord-006139-9063uhox	46	21	88	88	CD
cord-006139-9063uhox	46	22	]	]	-RRB-
cord-006139-9063uhox	46	23	[	[	-LRB-
cord-006139-9063uhox	46	24	89	89	CD
cord-006139-9063uhox	46	25	]	]	-RRB-
cord-006139-9063uhox	46	26	.	.	.
cord-006139-9063uhox	47	1	The	the	DT
cord-006139-9063uhox	47	2	resulting	result	VBG
cord-006139-9063uhox	47	3	peptides	peptide	NNS
cord-006139-9063uhox	47	4	are	be	VBP
cord-006139-9063uhox	47	5	ultimately	ultimately	RB
cord-006139-9063uhox	47	6	hydrolyzed	hydrolyze	VBN
cord-006139-9063uhox	47	7	to	to	IN
cord-006139-9063uhox	47	8	amino	amino	JJ
cord-006139-9063uhox	47	9	acids	acid	NNS
cord-006139-9063uhox	47	10	.	.	.
cord-006139-9063uhox	48	1	Currently	currently	RB
cord-006139-9063uhox	48	2	,	,	,
cord-006139-9063uhox	48	3	agreement	agreement	NN
cord-006139-9063uhox	48	4	about	about	IN
cord-006139-9063uhox	48	5	the	the	DT
cord-006139-9063uhox	48	6	details	detail	NNS
cord-006139-9063uhox	48	7	of	of	IN
cord-006139-9063uhox	48	8	this	this	DT
cord-006139-9063uhox	48	9	step	step	NN
cord-006139-9063uhox	48	10	has	have	VBZ
cord-006139-9063uhox	48	11	not	not	RB
cord-006139-9063uhox	48	12	been	be	VBN
cord-006139-9063uhox	48	13	reached	reach	VBN
cord-006139-9063uhox	48	14	[	[	-LRB-
cord-006139-9063uhox	48	15	90	90	CD
cord-006139-9063uhox	48	16	]	]	-RRB-
cord-006139-9063uhox	49	1	[	[	-LRB-
cord-006139-9063uhox	49	2	91	91	CD
cord-006139-9063uhox	49	3	]	]	-RRB-
cord-006139-9063uhox	49	4	[	[	-LRB-
cord-006139-9063uhox	49	5	92	92	CD
cord-006139-9063uhox	49	6	]	]	-RRB-
cord-006139-9063uhox	49	7	.	.	.
cord-006139-9063uhox	50	1	The	the	DT
cord-006139-9063uhox	50	2	toxic	toxic	JJ
cord-006139-9063uhox	50	3	heme	heme	NN
cord-006139-9063uhox	50	4	released	release	VBN
cord-006139-9063uhox	50	5	during	during	IN
cord-006139-9063uhox	50	6	hemoglobin	hemoglobin	NN
cord-006139-9063uhox	50	7	digestion	digestion	NN
cord-006139-9063uhox	50	8	is	be	VBZ
cord-006139-9063uhox	50	9	oxidized	oxidize	VBN
cord-006139-9063uhox	50	10	to	to	IN
cord-006139-9063uhox	50	11	the	the	DT
cord-006139-9063uhox	50	12	Fe(III	Fe(III	NNPS
cord-006139-9063uhox	50	13	)	)	-RRB-
cord-006139-9063uhox	50	14	state	state	NN
cord-006139-9063uhox	50	15	and	and	CC
cord-006139-9063uhox	50	16	then	then	RB
cord-006139-9063uhox	50	17	incorporated	incorporate	VBN
cord-006139-9063uhox	50	18	in	in	IN
cord-006139-9063uhox	50	19	less	less	RBR
cord-006139-9063uhox	50	20	-	-	HYPH
cord-006139-9063uhox	50	21	toxic	toxic	JJ
cord-006139-9063uhox	50	22	hemozoin	hemozoin	NN
cord-006139-9063uhox	50	23	in	in	IN
cord-006139-9063uhox	50	24	a	a	DT
cord-006139-9063uhox	50	25	process	process	NN
cord-006139-9063uhox	50	26	associated	associate	VBN
cord-006139-9063uhox	50	27	with	with	IN
cord-006139-9063uhox	50	28	neutral	neutral	JJ
cord-006139-9063uhox	50	29	lipids	lipid	NNS
cord-006139-9063uhox	50	30	[	[	-LRB-
cord-006139-9063uhox	50	31	93	93	CD
cord-006139-9063uhox	50	32	,	,	,
cord-006139-9063uhox	50	33	94	94	CD
cord-006139-9063uhox	50	34	]	]	-RRB-
cord-006139-9063uhox	50	35	,	,	,
cord-006139-9063uhox	50	36	represented	represent	VBN
cord-006139-9063uhox	50	37	in	in	IN
cord-006139-9063uhox	50	38	the	the	DT
cord-006139-9063uhox	50	39	figure	figure	NN
cord-006139-9063uhox	50	40	by	by	IN
cord-006139-9063uhox	50	41	the	the	DT
cord-006139-9063uhox	50	42	elliptical	elliptical	JJ
cord-006139-9063uhox	50	43	structure	structure	NN
cord-006139-9063uhox	50	44	enclosing	enclose	VBG
cord-006139-9063uhox	50	45	the	the	DT
cord-006139-9063uhox	50	46	hemozoin	hemozoin	NNP
cord-006139-9063uhox	50	47	crystals	crystal	NNS
cord-006139-9063uhox	50	48	.	.	.
cord-006139-9063uhox	51	1	HAP	HAP	NNP
cord-006139-9063uhox	51	2	:	:	:
cord-006139-9063uhox	52	1	Histoaspartic	histoaspartic	JJ
cord-006139-9063uhox	52	2	protease	protease	NN
cord-006139-9063uhox	52	3	;	;	:
cord-006139-9063uhox	52	4	RBC	RBC	NNP
cord-006139-9063uhox	52	5	:	:	:
cord-006139-9063uhox	52	6	Red	red	JJ
cord-006139-9063uhox	52	7	blood	blood	NN
cord-006139-9063uhox	52	8	cell	cell	NN
cord-006139-9063uhox	52	9	.	.	.
cord-006139-9063uhox	53	1	future	future	JJ
cord-006139-9063uhox	53	2	science	science	NN
cord-006139-9063uhox	53	3	group	group	NN
cord-006139-9063uhox	53	4	P.	P.	NNP
cord-006139-9063uhox	53	5	falciparum	falciparum	NN
cord-006139-9063uhox	53	6	could	could	MD
cord-006139-9063uhox	53	7	be	be	VB
cord-006139-9063uhox	53	8	accounted	account	VBN
cord-006139-9063uhox	53	9	for	for	IN
cord-006139-9063uhox	53	10	on	on	IN
cord-006139-9063uhox	53	11	the	the	DT
cord-006139-9063uhox	53	12	basis	basis	NN
cord-006139-9063uhox	53	13	of	of	IN
cord-006139-9063uhox	53	14	an	an	DT
cord-006139-9063uhox	53	15	additional	additional	JJ
cord-006139-9063uhox	53	16	interaction	interaction	NN
cord-006139-9063uhox	53	17	:	:	:
cord-006139-9063uhox	53	18	a	a	DT
cord-006139-9063uhox	53	19	chargeassisted	chargeassiste	VBN
cord-006139-9063uhox	53	20	hydrogen	hydrogen	NN
cord-006139-9063uhox	53	21	bond	bond	NN
cord-006139-9063uhox	53	22	between	between	IN
cord-006139-9063uhox	53	23	a	a	DT
cord-006139-9063uhox	53	24	protonated	protonated	JJ
cord-006139-9063uhox	53	25	amine	amine	NN
cord-006139-9063uhox	53	26	nitrogen	nitrogen	NN
cord-006139-9063uhox	53	27	atom	atom	NN
cord-006139-9063uhox	53	28	in	in	IN
cord-006139-9063uhox	53	29	the	the	DT
cord-006139-9063uhox	53	30	side	side	NN
cord-006139-9063uhox	53	31	chain	chain	NN
cord-006139-9063uhox	53	32	of	of	IN
cord-006139-9063uhox	53	33	the	the	DT
cord-006139-9063uhox	53	34	drug	drug	NN
cord-006139-9063uhox	53	35	and	and	CC
cord-006139-9063uhox	53	36	one	one	CD
cord-006139-9063uhox	53	37	of	of	IN
cord-006139-9063uhox	53	38	the	the	DT
cord-006139-9063uhox	53	39	heme	heme	NN
cord-006139-9063uhox	53	40	propionate	propionate	NN
cord-006139-9063uhox	53	41	groups	group	NNS
cord-006139-9063uhox	53	42	.	.	.
cord-006139-9063uhox	54	1	This	this	DT
cord-006139-9063uhox	54	2	interaction	interaction	NN
cord-006139-9063uhox	54	3	has	have	VBZ
cord-006139-9063uhox	54	4	recently	recently	RB
cord-006139-9063uhox	54	5	been	be	VBN
cord-006139-9063uhox	54	6	confirmed	confirm	VBN
cord-006139-9063uhox	54	7	in	in	IN
cord-006139-9063uhox	54	8	crystal	crystal	NN
cord-006139-9063uhox	54	9	structures	structure	NNS
cord-006139-9063uhox	54	10	of	of	IN
cord-006139-9063uhox	54	11	quinine	quinine	NN
cord-006139-9063uhox	54	12	-	-	HYPH
cord-006139-9063uhox	54	13	Fe(III)heme	fe(iii)heme	CD
cord-006139-9063uhox	54	14	and	and	CC
cord-006139-9063uhox	54	15	quinidine	quinidine	NN
cord-006139-9063uhox	54	16	-	-	HYPH
cord-006139-9063uhox	54	17	Fe(III)heme	Fe(III)heme	NNP
cord-006139-9063uhox	54	18	(	(	-LRB-
cord-006139-9063uhox	54	19	Figure	Figure	NNP
cord-006139-9063uhox	54	20	2B	2B	NNP
cord-006139-9063uhox	54	21	&	&	CC
cord-006139-9063uhox	54	22	2C	2C	NNP
cord-006139-9063uhox	54	23	)	)	-RRB-
cord-006139-9063uhox	54	24	[	[	-LRB-
cord-006139-9063uhox	54	25	20	20	CD
cord-006139-9063uhox	54	26	]	]	-RRB-
cord-006139-9063uhox	54	27	.	.	.
cord-006139-9063uhox	55	1	By	by	IN
cord-006139-9063uhox	55	2	contrast	contrast	NN
cord-006139-9063uhox	55	3	,	,	,
cord-006139-9063uhox	55	4	the	the	DT
cord-006139-9063uhox	55	5	structures	structure	NNS
cord-006139-9063uhox	55	6	of	of	IN
cord-006139-9063uhox	55	7	4-aminoquinoline	4-aminoquinoline	CD
cord-006139-9063uhox	55	8	-	-	HYPH
cord-006139-9063uhox	55	9	Fe(III)heme	fe(iii)heme	CD
cord-006139-9063uhox	55	10	complexes	complex	NNS
cord-006139-9063uhox	55	11	remain	remain	VBP
cord-006139-9063uhox	55	12	less	less	RBR
cord-006139-9063uhox	55	13	well	well	RB
cord-006139-9063uhox	55	14	understood	understand	VBN
cord-006139-9063uhox	55	15	,	,	,
cord-006139-9063uhox	55	16	despite	despite	IN
cord-006139-9063uhox	55	17	various	various	JJ
cord-006139-9063uhox	55	18	efforts	effort	NNS
cord-006139-9063uhox	55	19	to	to	TO
cord-006139-9063uhox	55	20	use	use	VB
cord-006139-9063uhox	55	21	nuclear	nuclear	JJ
cord-006139-9063uhox	55	22	magnetic	magnetic	JJ
cord-006139-9063uhox	55	23	resonance	resonance	NN
cord-006139-9063uhox	55	24	techniques	technique	NNS
cord-006139-9063uhox	55	25	to	to	TO
cord-006139-9063uhox	55	26	elucidate	elucidate	VB
cord-006139-9063uhox	55	27	them	-PRON-	PRP
cord-006139-9063uhox	55	28	[	[	-LRB-
cord-006139-9063uhox	55	29	21	21	CD
cord-006139-9063uhox	55	30	]	]	-RRB-
cord-006139-9063uhox	55	31	[	[	-LRB-
cord-006139-9063uhox	55	32	22	22	CD
cord-006139-9063uhox	55	33	]	]	-RRB-
cord-006139-9063uhox	55	34	[	[	-LRB-
cord-006139-9063uhox	55	35	23	23	CD
cord-006139-9063uhox	55	36	]	]	-RRB-
cord-006139-9063uhox	55	37	[	[	-LRB-
cord-006139-9063uhox	55	38	24	24	CD
cord-006139-9063uhox	55	39	]	]	-RRB-
cord-006139-9063uhox	55	40	[	[	-LRB-
cord-006139-9063uhox	55	41	25	25	CD
cord-006139-9063uhox	55	42	]	]	-RRB-
cord-006139-9063uhox	55	43	[	[	-LRB-
cord-006139-9063uhox	55	44	26	26	CD
cord-006139-9063uhox	55	45	]	]	-RRB-
cord-006139-9063uhox	55	46	[	[	-LRB-
cord-006139-9063uhox	55	47	27	27	CD
cord-006139-9063uhox	55	48	]	]	-RRB-
cord-006139-9063uhox	55	49	[	[	-LRB-
cord-006139-9063uhox	55	50	28	28	CD
cord-006139-9063uhox	55	51	]	]	-RRB-
cord-006139-9063uhox	55	52	[	[	-LRB-
cord-006139-9063uhox	55	53	29	29	CD
cord-006139-9063uhox	55	54	]	]	-RRB-
cord-006139-9063uhox	55	55	.	.	.
cord-006139-9063uhox	56	1	In	in	IN
cord-006139-9063uhox	56	2	addition	addition	NN
cord-006139-9063uhox	56	3	,	,	,
cord-006139-9063uhox	56	4	the	the	DT
cord-006139-9063uhox	56	5	precise	precise	JJ
cord-006139-9063uhox	56	6	relationship	relationship	NN
cord-006139-9063uhox	56	7	between	between	IN
cord-006139-9063uhox	56	8	heme	heme	NN
cord-006139-9063uhox	56	9	binding	binding	NN
cord-006139-9063uhox	56	10	and	and	CC
cord-006139-9063uhox	56	11	hemozoin	hemozoin	NNP
cord-006139-9063uhox	56	12	inhibition	inhibition	NN
cord-006139-9063uhox	56	13	remains	remain	VBZ
cord-006139-9063uhox	56	14	unclear	unclear	JJ
cord-006139-9063uhox	56	15	.	.	.
cord-006139-9063uhox	57	1	Early	early	JJ
cord-006139-9063uhox	57	2	postulates	postulate	NNS
cord-006139-9063uhox	57	3	involved	involve	VBD
cord-006139-9063uhox	57	4	stoichiometric	stoichiometric	JJ
cord-006139-9063uhox	57	5	solution	solution	NN
cord-006139-9063uhox	57	6	complexes	complex	NNS
cord-006139-9063uhox	57	7	of	of	IN
cord-006139-9063uhox	57	8	antimalarials	antimalarial	NNS
cord-006139-9063uhox	57	9	with	with	IN
cord-006139-9063uhox	57	10	Fe(III)heme	Fe(III)heme	NNP
cord-006139-9063uhox	57	11	[	[	-LRB-
cord-006139-9063uhox	57	12	30	30	CD
cord-006139-9063uhox	57	13	]	]	-RRB-
cord-006139-9063uhox	57	14	and	and	CC
cord-006139-9063uhox	57	15	included	include	VBD
cord-006139-9063uhox	57	16	suggestions	suggestion	NNS
cord-006139-9063uhox	57	17	that	that	IN
cord-006139-9063uhox	57	18	drugs	drug	NNS
cord-006139-9063uhox	57	19	act	act	VBP
cord-006139-9063uhox	57	20	by	by	IN
cord-006139-9063uhox	57	21	increasing	increase	VBG
cord-006139-9063uhox	57	22	Fe(III)heme	fe(iii)heme	CD
cord-006139-9063uhox	57	23	solubility	solubility	NN
cord-006139-9063uhox	57	24	,	,	,
cord-006139-9063uhox	57	25	thus	thus	RB
cord-006139-9063uhox	57	26	preventing	prevent	VBG
cord-006139-9063uhox	57	27	aggregation	aggregation	NN
cord-006139-9063uhox	57	28	[	[	-LRB-
cord-006139-9063uhox	57	29	30	30	CD
cord-006139-9063uhox	57	30	,	,	,
cord-006139-9063uhox	57	31	31	31	CD
cord-006139-9063uhox	57	32	]	]	-RRB-
cord-006139-9063uhox	57	33	.	.	.
cord-006139-9063uhox	58	1	More	more	RBR
cord-006139-9063uhox	58	2	recently	recently	RB
cord-006139-9063uhox	58	3	,	,	,
cord-006139-9063uhox	58	4	however	however	RB
cord-006139-9063uhox	58	5	,	,	,
cord-006139-9063uhox	58	6	an	an	DT
cord-006139-9063uhox	58	7	alternative	alternative	JJ
cord-006139-9063uhox	58	8	suggestion	suggestion	NN
cord-006139-9063uhox	58	9	by	by	IN
cord-006139-9063uhox	58	10	Buller	Buller	NNP
cord-006139-9063uhox	58	11	et	et	NNP
cord-006139-9063uhox	58	12	al	al	NNP
cord-006139-9063uhox	58	13	.	.	NNP
cord-006139-9063uhox	58	14	has	have	VBZ
cord-006139-9063uhox	58	15	enjoyed	enjoy	VBN
cord-006139-9063uhox	58	16	considerable	considerable	JJ
cord-006139-9063uhox	58	17	attention	attention	NN
cord-006139-9063uhox	58	18	[	[	-LRB-
cord-006139-9063uhox	58	19	32	32	CD
cord-006139-9063uhox	58	20	]	]	-RRB-
cord-006139-9063uhox	58	21	.	.	.
cord-006139-9063uhox	59	1	These	these	DT
cord-006139-9063uhox	59	2	authors	author	NNS
cord-006139-9063uhox	59	3	,	,	,
cord-006139-9063uhox	59	4	among	among	IN
cord-006139-9063uhox	59	5	others	other	NNS
cord-006139-9063uhox	59	6	,	,	,
cord-006139-9063uhox	59	7	have	have	VBP
cord-006139-9063uhox	59	8	suggested	suggest	VBN
cord-006139-9063uhox	59	9	that	that	IN
cord-006139-9063uhox	59	10	this	this	DT
cord-006139-9063uhox	59	11	class	class	NN
cord-006139-9063uhox	59	12	of	of	IN
cord-006139-9063uhox	59	13	drug	drug	NN
cord-006139-9063uhox	59	14	can	can	MD
cord-006139-9063uhox	59	15	dock	dock	VB
cord-006139-9063uhox	59	16	into	into	IN
cord-006139-9063uhox	59	17	the	the	DT
cord-006139-9063uhox	59	18	fastest	fast	RBS
cord-006139-9063uhox	59	19	-	-	HYPH
cord-006139-9063uhox	59	20	growing	grow	VBG
cord-006139-9063uhox	59	21	face	face	NN
cord-006139-9063uhox	59	22	of	of	IN
cord-006139-9063uhox	59	23	the	the	DT
cord-006139-9063uhox	59	24	hemozoin	hemozoin	NNP
cord-006139-9063uhox	59	25	crystal	crystal	NN
cord-006139-9063uhox	59	26	,	,	,
cord-006139-9063uhox	59	27	as	as	RB
cord-006139-9063uhox	59	28	well	well	RB
cord-006139-9063uhox	59	29	as	as	IN
cord-006139-9063uhox	59	30	inhibit	inhibit	VBN
cord-006139-9063uhox	59	31	growth	growth	NN
cord-006139-9063uhox	59	32	of	of	IN
cord-006139-9063uhox	59	33	some	some	DT
cord-006139-9063uhox	59	34	of	of	IN
cord-006139-9063uhox	59	35	the	the	DT
cord-006139-9063uhox	59	36	other	other	JJ
cord-006139-9063uhox	59	37	faces	face	NNS
cord-006139-9063uhox	59	38	[	[	-LRB-
cord-006139-9063uhox	59	39	32	32	CD
cord-006139-9063uhox	59	40	]	]	-RRB-
cord-006139-9063uhox	59	41	[	[	-LRB-
cord-006139-9063uhox	59	42	33	33	CD
cord-006139-9063uhox	59	43	]	]	-RRB-
cord-006139-9063uhox	59	44	[	[	-LRB-
cord-006139-9063uhox	59	45	34	34	CD
cord-006139-9063uhox	59	46	]	]	-RRB-
cord-006139-9063uhox	59	47	[	[	-LRB-
cord-006139-9063uhox	59	48	35	35	CD
cord-006139-9063uhox	59	49	]	]	-RRB-
cord-006139-9063uhox	59	50	.	.	.
cord-006139-9063uhox	60	1	This	this	DT
cord-006139-9063uhox	60	2	hypothesis	hypothesis	NN
cord-006139-9063uhox	60	3	has	have	VBZ
cord-006139-9063uhox	60	4	been	be	VBN
cord-006139-9063uhox	60	5	able	able	JJ
cord-006139-9063uhox	60	6	to	to	TO
cord-006139-9063uhox	60	7	mathematically	mathematically	RB
cord-006139-9063uhox	60	8	account	account	VB
cord-006139-9063uhox	60	9	for	for	IN
cord-006139-9063uhox	60	10	the	the	DT
cord-006139-9063uhox	60	11	effects	effect	NNS
cord-006139-9063uhox	60	12	of	of	IN
cord-006139-9063uhox	60	13	chloroquine	chloroquine	NN
cord-006139-9063uhox	60	14	and	and	CC
cord-006139-9063uhox	60	15	quinidine	quinidine	NN
cord-006139-9063uhox	60	16	on	on	IN
cord-006139-9063uhox	60	17	the	the	DT
cord-006139-9063uhox	60	18	kinetics	kinetic	NNS
cord-006139-9063uhox	60	19	of	of	IN
cord-006139-9063uhox	60	20	synthetic	synthetic	JJ
cord-006139-9063uhox	60	21	hemozoin	hemozoin	NNP
cord-006139-9063uhox	60	22	(	(	-LRB-
cord-006139-9063uhox	60	23	b	b	NN
cord-006139-9063uhox	60	24	-	-	HYPH
cord-006139-9063uhox	60	25	hematin	hematin	NNP
cord-006139-9063uhox	60	26	)	)	-RRB-
cord-006139-9063uhox	60	27	formation	formation	NN
cord-006139-9063uhox	60	28	[	[	-LRB-
cord-006139-9063uhox	60	29	36	36	CD
cord-006139-9063uhox	60	30	]	]	-RRB-
cord-006139-9063uhox	60	31	.	.	.
cord-006139-9063uhox	61	1	In	in	IN
cord-006139-9063uhox	61	2	addition	addition	NN
cord-006139-9063uhox	61	3	,	,	,
cord-006139-9063uhox	61	4	it	-PRON-	PRP
cord-006139-9063uhox	61	5	can	can	MD
cord-006139-9063uhox	61	6	also	also	RB
cord-006139-9063uhox	61	7	explain	explain	VB
cord-006139-9063uhox	61	8	how	how	WRB
cord-006139-9063uhox	61	9	substoichiometric	substoichiometric	JJ
cord-006139-9063uhox	61	10	quantities	quantity	NNS
cord-006139-9063uhox	61	11	of	of	IN
cord-006139-9063uhox	61	12	a	a	DT
cord-006139-9063uhox	61	13	drug	drug	NN
cord-006139-9063uhox	61	14	can	can	MD
cord-006139-9063uhox	61	15	inhibit	inhibit	VB
cord-006139-9063uhox	61	16	hemozoin	hemozoin	NNP
cord-006139-9063uhox	61	17	formation	formation	NN
cord-006139-9063uhox	61	18	and	and	CC
cord-006139-9063uhox	61	19	provides	provide	VBZ
cord-006139-9063uhox	61	20	a	a	DT
cord-006139-9063uhox	61	21	well	well	RB
cord-006139-9063uhox	61	22	-	-	HYPH
cord-006139-9063uhox	61	23	defined	define	VBN
cord-006139-9063uhox	61	24	binding	binding	NN
cord-006139-9063uhox	61	25	site	site	NN
cord-006139-9063uhox	61	26	for	for	IN
cord-006139-9063uhox	61	27	these	these	DT
cord-006139-9063uhox	61	28	compounds	compound	NNS
cord-006139-9063uhox	61	29	.	.	.
cord-006139-9063uhox	62	1	To	to	IN
cord-006139-9063uhox	62	2	date	date	NN
cord-006139-9063uhox	62	3	,	,	,
cord-006139-9063uhox	62	4	however	however	RB
cord-006139-9063uhox	62	5	,	,	,
cord-006139-9063uhox	62	6	this	this	DT
cord-006139-9063uhox	62	7	model	model	NN
cord-006139-9063uhox	62	8	does	do	VBZ
cord-006139-9063uhox	62	9	not	not	RB
cord-006139-9063uhox	62	10	appear	appear	VB
cord-006139-9063uhox	62	11	to	to	TO
cord-006139-9063uhox	62	12	have	have	VB
cord-006139-9063uhox	62	13	been	be	VBN
cord-006139-9063uhox	62	14	directly	directly	RB
cord-006139-9063uhox	62	15	used	use	VBN
cord-006139-9063uhox	62	16	to	to	TO
cord-006139-9063uhox	62	17	try	try	VB
cord-006139-9063uhox	62	18	to	to	TO
cord-006139-9063uhox	62	19	design	design	VB
cord-006139-9063uhox	62	20	new	new	JJ
cord-006139-9063uhox	62	21	inhibitors	inhibitor	NNS
cord-006139-9063uhox	62	22	using	use	VBG
cord-006139-9063uhox	62	23	a	a	DT
cord-006139-9063uhox	62	24	rational	rational	JJ
cord-006139-9063uhox	62	25	approach	approach	NN
cord-006139-9063uhox	62	26	,	,	,
cord-006139-9063uhox	62	27	probably	probably	RB
cord-006139-9063uhox	62	28	because	because	IN
cord-006139-9063uhox	62	29	conventional	conventional	JJ
cord-006139-9063uhox	62	30	drug	drug	NN
cord-006139-9063uhox	62	31	-	-	HYPH
cord-006139-9063uhox	62	32	docking	docking	NN
cord-006139-9063uhox	62	33	programs	program	NNS
cord-006139-9063uhox	62	34	are	be	VBP
cord-006139-9063uhox	62	35	not	not	RB
cord-006139-9063uhox	62	36	able	able	JJ
cord-006139-9063uhox	62	37	to	to	TO
cord-006139-9063uhox	62	38	handle	handle	VB
cord-006139-9063uhox	62	39	crystal	crystal	NN
cord-006139-9063uhox	62	40	surfaces	surface	NNS
cord-006139-9063uhox	62	41	well	well	RB
cord-006139-9063uhox	62	42	.	.	.
cord-006139-9063uhox	63	1	Despite	despite	IN
cord-006139-9063uhox	63	2	ample	ample	JJ
cord-006139-9063uhox	63	3	evidence	evidence	NN
cord-006139-9063uhox	63	4	that	that	IN
cord-006139-9063uhox	63	5	quinoline	quinoline	JJ
cord-006139-9063uhox	63	6	and	and	CC
cord-006139-9063uhox	63	7	related	relate	VBN
cord-006139-9063uhox	63	8	antimalarials	antimalarial	NNS
cord-006139-9063uhox	63	9	inhibit	inhibit	VBP
cord-006139-9063uhox	63	10	b	b	NN
cord-006139-9063uhox	63	11	-	-	HYPH
cord-006139-9063uhox	63	12	hematin	hematin	NN
cord-006139-9063uhox	63	13	formation	formation	NN
cord-006139-9063uhox	63	14	under	under	IN
cord-006139-9063uhox	63	15	abiotic	abiotic	JJ
cord-006139-9063uhox	63	16	and	and	CC
cord-006139-9063uhox	63	17	biomimetic	biomimetic	JJ
cord-006139-9063uhox	63	18	conditions	condition	NNS
cord-006139-9063uhox	63	19	,	,	,
cord-006139-9063uhox	63	20	direct	direct	JJ
cord-006139-9063uhox	63	21	evidence	evidence	NN
cord-006139-9063uhox	63	22	of	of	IN
cord-006139-9063uhox	63	23	inhibition	inhibition	NN
cord-006139-9063uhox	63	24	of	of	IN
cord-006139-9063uhox	63	25	hemozoin	hemozoin	NNP
cord-006139-9063uhox	63	26	formation	formation	NN
cord-006139-9063uhox	63	27	in	in	IN
cord-006139-9063uhox	63	28	the	the	DT
cord-006139-9063uhox	63	29	parasite	parasite	NN
cord-006139-9063uhox	63	30	itself	-PRON-	PRP
cord-006139-9063uhox	63	31	is	be	VBZ
cord-006139-9063uhox	63	32	much	much	RB
cord-006139-9063uhox	63	33	more	more	RBR
cord-006139-9063uhox	63	34	sparse	sparse	JJ
cord-006139-9063uhox	63	35	.	.	.
cord-006139-9063uhox	64	1	Chloroquine	Chloroquine	NNP
cord-006139-9063uhox	64	2	and	and	CC
cord-006139-9063uhox	64	3	,	,	,
cord-006139-9063uhox	64	4	more	more	RBR
cord-006139-9063uhox	64	5	recently	recently	RB
cord-006139-9063uhox	64	6	,	,	,
cord-006139-9063uhox	64	7	ruthenoquine	ruthenoquine	NN
cord-006139-9063uhox	64	8	,	,	,
cord-006139-9063uhox	64	9	an	an	DT
cord-006139-9063uhox	64	10	analog	analog	NN
cord-006139-9063uhox	64	11	of	of	IN
cord-006139-9063uhox	64	12	the	the	DT
cord-006139-9063uhox	64	13	4-aminoquinoline	4-aminoquinoline	CD
cord-006139-9063uhox	64	14	ferroquine	ferroquine	NN
cord-006139-9063uhox	64	15	in	in	IN
cord-006139-9063uhox	64	16	which	which	WDT
cord-006139-9063uhox	64	17	the	the	DT
cord-006139-9063uhox	64	18	ferrocene	ferrocene	NN
cord-006139-9063uhox	64	19	moiety	moiety	NN
cord-006139-9063uhox	64	20	is	be	VBZ
cord-006139-9063uhox	64	21	replaced	replace	VBN
cord-006139-9063uhox	64	22	by	by	IN
cord-006139-9063uhox	64	23	ruthenocene	ruthenocene	NN
cord-006139-9063uhox	64	24	,	,	,
cord-006139-9063uhox	64	25	have	have	VBP
cord-006139-9063uhox	64	26	been	be	VBN
cord-006139-9063uhox	64	27	shown	show	VBN
cord-006139-9063uhox	64	28	to	to	TO
cord-006139-9063uhox	64	29	accumulate	accumulate	VB
cord-006139-9063uhox	64	30	in	in	IN
cord-006139-9063uhox	64	31	the	the	DT
cord-006139-9063uhox	64	32	parasite	parasite	NN
cord-006139-9063uhox	64	33	DV	dv	NN
cord-006139-9063uhox	64	34	in	in	IN
cord-006139-9063uhox	64	35	close	close	JJ
cord-006139-9063uhox	64	36	proximity	proximity	NN
cord-006139-9063uhox	64	37	to	to	IN
cord-006139-9063uhox	64	38	hemozoin	hemozoin	NNP
cord-006139-9063uhox	64	39	[	[	-LRB-
cord-006139-9063uhox	64	40	37	37	CD
cord-006139-9063uhox	64	41	,	,	,
cord-006139-9063uhox	64	42	38	38	CD
cord-006139-9063uhox	64	43	]	]	-RRB-
cord-006139-9063uhox	64	44	.	.	.
cord-006139-9063uhox	65	1	Smaller	small	JJR
cord-006139-9063uhox	65	2	hemozoin	hemozoin	NNP
cord-006139-9063uhox	65	3	crystals	crystal	NNS
cord-006139-9063uhox	65	4	and	and	CC
cord-006139-9063uhox	65	5	a	a	DT
cord-006139-9063uhox	65	6	premature	premature	JJ
cord-006139-9063uhox	65	7	halt	halt	NN
cord-006139-9063uhox	65	8	in	in	IN
cord-006139-9063uhox	65	9	their	-PRON-	PRP$
cord-006139-9063uhox	65	10	growth	growth	NN
cord-006139-9063uhox	65	11	within	within	IN
cord-006139-9063uhox	65	12	the	the	DT
cord-006139-9063uhox	65	13	parasite	parasite	NN
cord-006139-9063uhox	65	14	DV	DV	NNP
cord-006139-9063uhox	65	15	has	have	VBZ
cord-006139-9063uhox	65	16	been	be	VBN
cord-006139-9063uhox	65	17	observed	observe	VBN
cord-006139-9063uhox	65	18	in	in	IN
cord-006139-9063uhox	65	19	the	the	DT
cord-006139-9063uhox	65	20	presence	presence	NN
cord-006139-9063uhox	65	21	of	of	IN
cord-006139-9063uhox	65	22	chloroquine	chloroquine	NN
cord-006139-9063uhox	65	23	[	[	-LRB-
cord-006139-9063uhox	65	24	39	39	CD
cord-006139-9063uhox	65	25	]	]	-RRB-
cord-006139-9063uhox	65	26	.	.	.
cord-006139-9063uhox	66	1	Finally	finally	RB
cord-006139-9063uhox	66	2	,	,	,
cord-006139-9063uhox	66	3	at	at	IN
cord-006139-9063uhox	66	4	120	120	CD
cord-006139-9063uhox	66	5	nM	nm	CD
cord-006139-9063uhox	66	6	and	and	CC
cord-006139-9063uhox	66	7	12-h	12-h	CD
cord-006139-9063uhox	66	8	incubation	incubation	NN
cord-006139-9063uhox	66	9	times	time	NNS
cord-006139-9063uhox	66	10	,	,	,
cord-006139-9063uhox	66	11	chloroquine	chloroquine	NN
cord-006139-9063uhox	66	12	causes	cause	VBZ
cord-006139-9063uhox	66	13	a	a	DT
cord-006139-9063uhox	66	14	build	build	NN
cord-006139-9063uhox	66	15	-	-	HYPH
cord-006139-9063uhox	66	16	up	up	NN
cord-006139-9063uhox	66	17	of	of	IN
cord-006139-9063uhox	66	18	transport	transport	NN
cord-006139-9063uhox	66	19	vesicles	vesicle	NNS
cord-006139-9063uhox	66	20	in	in	IN
cord-006139-9063uhox	66	21	the	the	DT
cord-006139-9063uhox	66	22	parasite	parasite	NN
cord-006139-9063uhox	66	23	,	,	,
cord-006139-9063uhox	66	24	which	which	WDT
cord-006139-9063uhox	66	25	contain	contain	VBP
cord-006139-9063uhox	66	26	undigested	undigested	JJ
cord-006139-9063uhox	66	27	Hb	Hb	NNP
cord-006139-9063uhox	66	28	[	[	-LRB-
cord-006139-9063uhox	66	29	40	40	CD
cord-006139-9063uhox	66	30	]	]	-RRB-
cord-006139-9063uhox	66	31	,	,	,
cord-006139-9063uhox	66	32	indicating	indicate	VBG
cord-006139-9063uhox	66	33	that	that	IN
cord-006139-9063uhox	66	34	the	the	DT
cord-006139-9063uhox	66	35	endocytotic	endocytotic	JJ
cord-006139-9063uhox	66	36	feeding	feeding	NN
cord-006139-9063uhox	66	37	process	process	NN
cord-006139-9063uhox	66	38	is	be	VBZ
cord-006139-9063uhox	66	39	inhibited	inhibit	VBN
cord-006139-9063uhox	66	40	.	.	.
cord-006139-9063uhox	67	1	Recently	recently	RB
cord-006139-9063uhox	67	2	,	,	,
cord-006139-9063uhox	67	3	a	a	DT
cord-006139-9063uhox	67	4	fractionation	fractionation	NN
cord-006139-9063uhox	67	5	strategy	strategy	NN
cord-006139-9063uhox	67	6	has	have	VBZ
cord-006139-9063uhox	67	7	been	be	VBN
cord-006139-9063uhox	67	8	applied	apply	VBN
cord-006139-9063uhox	67	9	together	together	RB
cord-006139-9063uhox	67	10	with	with	IN
cord-006139-9063uhox	67	11	electron	electron	NN
cord-006139-9063uhox	67	12	spectroscopic	spectroscopic	JJ
cord-006139-9063uhox	67	13	imaging	image	VBG
cord-006139-9063uhox	67	14	to	to	IN
cord-006139-9063uhox	67	15	chloroquine	chloroquine	NN
cord-006139-9063uhox	67	16	-	-	HYPH
cord-006139-9063uhox	67	17	treated	treat	VBN
cord-006139-9063uhox	67	18	P.	p.	NN
cord-006139-9063uhox	67	19	falciparum	falciparum	NN
cord-006139-9063uhox	67	20	[	[	-LRB-
cord-006139-9063uhox	67	21	41	41	CD
cord-006139-9063uhox	67	22	]	]	-RRB-
cord-006139-9063uhox	67	23	.	.	.
cord-006139-9063uhox	68	1	This	this	DT
cord-006139-9063uhox	68	2	has	have	VBZ
cord-006139-9063uhox	68	3	clearly	clearly	RB
cord-006139-9063uhox	68	4	shown	show	VBN
cord-006139-9063uhox	68	5	a	a	DT
cord-006139-9063uhox	68	6	dose	dose	NN
cord-006139-9063uhox	68	7	-	-	HYPH
cord-006139-9063uhox	68	8	dependent	dependent	JJ
cord-006139-9063uhox	68	9	increase	increase	NN
cord-006139-9063uhox	68	10	in	in	IN
cord-006139-9063uhox	68	11	free	free	JJ
cord-006139-9063uhox	68	12	Fe(III)heme	fe(iii)heme	CD
cord-006139-9063uhox	68	13	occurring	occur	VBG
cord-006139-9063uhox	68	14	together	together	RB
cord-006139-9063uhox	68	15	with	with	IN
cord-006139-9063uhox	68	16	the	the	DT
cord-006139-9063uhox	68	17	decrease	decrease	NN
cord-006139-9063uhox	68	18	in	in	IN
cord-006139-9063uhox	68	19	hemozoin	hemozoin	NNP
cord-006139-9063uhox	68	20	.	.	.
cord-006139-9063uhox	69	1	Undigested	undigested	JJ
cord-006139-9063uhox	69	2	Hb	Hb	NNP
cord-006139-9063uhox	69	3	only	only	RB
cord-006139-9063uhox	69	4	seems	seem	VBZ
cord-006139-9063uhox	69	5	to	to	TO
cord-006139-9063uhox	69	6	appear	appear	VB
cord-006139-9063uhox	69	7	at	at	IN
cord-006139-9063uhox	69	8	higher	high	JJR
cord-006139-9063uhox	69	9	doses	dose	NNS
cord-006139-9063uhox	69	10	of	of	IN
cord-006139-9063uhox	69	11	chloroquine	chloroquine	NN
cord-006139-9063uhox	69	12	,	,	,
cord-006139-9063uhox	69	13	and	and	CC
cord-006139-9063uhox	69	14	the	the	DT
cord-006139-9063uhox	69	15	levels	level	NNS
cord-006139-9063uhox	69	16	of	of	IN
cord-006139-9063uhox	69	17	free	free	JJ
cord-006139-9063uhox	69	18	Fe(III)heme	Fe(III)heme	NNS
cord-006139-9063uhox	69	19	are	be	VBP
cord-006139-9063uhox	69	20	closely	closely	RB
cord-006139-9063uhox	69	21	correlated	correlate	VBN
cord-006139-9063uhox	69	22	with	with	IN
cord-006139-9063uhox	69	23	the	the	DT
cord-006139-9063uhox	69	24	parasite	parasite	NN
cord-006139-9063uhox	69	25	survival	survival	NN
cord-006139-9063uhox	69	26	curve	curve	NN
cord-006139-9063uhox	69	27	(	(	-LRB-
cord-006139-9063uhox	69	28	Figure	figure	NN
cord-006139-9063uhox	69	29	3	3	CD
cord-006139-9063uhox	69	30	)	)	-RRB-
cord-006139-9063uhox	69	31	.	.	.
cord-006139-9063uhox	70	1	Electron	electron	NN
cord-006139-9063uhox	70	2	spectroscopic	spectroscopic	JJ
cord-006139-9063uhox	70	3	imaging	imaging	NN
cord-006139-9063uhox	70	4	using	use	VBG
cord-006139-9063uhox	70	5	electron	electron	NN
cord-006139-9063uhox	70	6	energy	energy	NN
cord-006139-9063uhox	70	7	loss	loss	NN
cord-006139-9063uhox	70	8	spectroscopy	spectroscopy	NN
cord-006139-9063uhox	70	9	clearly	clearly	RB
cord-006139-9063uhox	70	10	showed	show	VBD
cord-006139-9063uhox	70	11	a	a	DT
cord-006139-9063uhox	70	12	translocation	translocation	NN
cord-006139-9063uhox	70	13	of	of	IN
cord-006139-9063uhox	70	14	iron	iron	NN
cord-006139-9063uhox	70	15	to	to	IN
cord-006139-9063uhox	70	16	the	the	DT
cord-006139-9063uhox	70	17	parasite	parasite	NN
cord-006139-9063uhox	70	18	cytoplasm	cytoplasm	NN
cord-006139-9063uhox	70	19	(	(	-LRB-
cord-006139-9063uhox	70	20	Figure	figure	NN
cord-006139-9063uhox	70	21	4A	4a	CD
cord-006139-9063uhox	70	22	&	&	CC
cord-006139-9063uhox	70	23	4B	4B	NNP
cord-006139-9063uhox	70	24	)	)	-RRB-
cord-006139-9063uhox	70	25	.	.	.
cord-006139-9063uhox	71	1	Since	since	IN
cord-006139-9063uhox	71	2	virtually	virtually	RB
cord-006139-9063uhox	71	3	all	all	DT
cord-006139-9063uhox	71	4	of	of	IN
cord-006139-9063uhox	71	5	the	the	DT
cord-006139-9063uhox	71	6	iron	iron	NN
cord-006139-9063uhox	71	7	present	present	NN
cord-006139-9063uhox	71	8	is	be	VBZ
cord-006139-9063uhox	71	9	heme	heme	JJ
cord-006139-9063uhox	71	10	iron	iron	NN
cord-006139-9063uhox	71	11	and	and	CC
cord-006139-9063uhox	71	12	there	there	EX
cord-006139-9063uhox	71	13	is	be	VBZ
cord-006139-9063uhox	71	14	little	little	JJ
cord-006139-9063uhox	71	15	undigested	undigested	JJ
cord-006139-9063uhox	71	16	Hb	Hb	NNP
cord-006139-9063uhox	71	17	at	at	IN
cord-006139-9063uhox	71	18	the	the	DT
cord-006139-9063uhox	71	19	dose	dose	NN
cord-006139-9063uhox	71	20	used	use	VBN
cord-006139-9063uhox	71	21	,	,	,
cord-006139-9063uhox	71	22	this	this	DT
cord-006139-9063uhox	71	23	is	be	VBZ
cord-006139-9063uhox	71	24	likely	likely	JJ
cord-006139-9063uhox	71	25	to	to	TO
cord-006139-9063uhox	71	26	be	be	VB
cord-006139-9063uhox	71	27	the	the	DT
cord-006139-9063uhox	71	28	location	location	NN
cord-006139-9063uhox	71	29	of	of	IN
cord-006139-9063uhox	71	30	the	the	DT
cord-006139-9063uhox	71	31	free	free	JJ
cord-006139-9063uhox	71	32	Fe(III)heme	fe(iii)heme	CD
cord-006139-9063uhox	71	33	.	.	.
cord-006139-9063uhox	72	1	There	there	RB
cord-006139-9063uhox	72	2	The	the	DT
cord-006139-9063uhox	72	3	aromatic	aromatic	JJ
cord-006139-9063uhox	72	4	ring	ring	NN
cord-006139-9063uhox	72	5	lies	lie	VBZ
cord-006139-9063uhox	72	6	parallel	parallel	JJ
cord-006139-9063uhox	72	7	to	to	IN
cord-006139-9063uhox	72	8	the	the	DT
cord-006139-9063uhox	72	9	porphyrin	porphyrin	NN
cord-006139-9063uhox	72	10	ring	ring	NN
cord-006139-9063uhox	72	11	in	in	IN
cord-006139-9063uhox	72	12	a	a	DT
cord-006139-9063uhox	72	13	p	p	NN
cord-006139-9063uhox	72	14	-	-	HYPH
cord-006139-9063uhox	72	15	stacking	stacking	NN
cord-006139-9063uhox	72	16	arrangement	arrangement	NN
cord-006139-9063uhox	72	17	.	.	.
cord-006139-9063uhox	73	1	In	in	IN
cord-006139-9063uhox	73	2	the	the	DT
cord-006139-9063uhox	73	3	cases	case	NNS
cord-006139-9063uhox	73	4	of	of	IN
cord-006139-9063uhox	73	5	the	the	DT
cord-006139-9063uhox	73	6	quinidine	quinidine	NN
cord-006139-9063uhox	73	7	and	and	CC
cord-006139-9063uhox	73	8	quinine	quinine	NN
cord-006139-9063uhox	73	9	complexes	complex	NNS
cord-006139-9063uhox	73	10	,	,	,
cord-006139-9063uhox	73	11	a	a	DT
cord-006139-9063uhox	73	12	charge	charge	NN
cord-006139-9063uhox	73	13	-	-	HYPH
cord-006139-9063uhox	73	14	assisted	assist	VBN
cord-006139-9063uhox	73	15	hydrogen	hydrogen	NN
cord-006139-9063uhox	73	16	bond	bond	NN
cord-006139-9063uhox	73	17	(	(	-LRB-
cord-006139-9063uhox	73	18	salt	salt	NN
cord-006139-9063uhox	73	19	bridge	bridge	NNP
cord-006139-9063uhox	73	20	)	)	-RRB-
cord-006139-9063uhox	73	21	occurs	occur	VBZ
cord-006139-9063uhox	73	22	between	between	IN
cord-006139-9063uhox	73	23	one	one	CD
cord-006139-9063uhox	73	24	of	of	IN
cord-006139-9063uhox	73	25	the	the	DT
cord-006139-9063uhox	73	26	heme	heme	NN
cord-006139-9063uhox	73	27	propionate	propionate	NN
cord-006139-9063uhox	73	28	groups	group	NNS
cord-006139-9063uhox	73	29	and	and	CC
cord-006139-9063uhox	73	30	the	the	DT
cord-006139-9063uhox	73	31	protonated	protonated	JJ
cord-006139-9063uhox	73	32	quinuclidine	quinuclidine	JJ
cord-006139-9063uhox	73	33	tertiary	tertiary	JJ
cord-006139-9063uhox	73	34	amino	amino	NN
cord-006139-9063uhox	73	35	group	group	NN
cord-006139-9063uhox	73	36	.	.	.
cord-006139-9063uhox	74	1	The	the	DT
cord-006139-9063uhox	74	2	structural	structural	JJ
cord-006139-9063uhox	74	3	models	model	NNS
cord-006139-9063uhox	74	4	shown	show	VBN
cord-006139-9063uhox	74	5	here	here	RB
cord-006139-9063uhox	74	6	were	be	VBD
cord-006139-9063uhox	74	7	created	create	VBN
cord-006139-9063uhox	74	8	using	use	VBG
cord-006139-9063uhox	74	9	data	datum	NNS
cord-006139-9063uhox	74	10	taken	take	VBN
cord-006139-9063uhox	74	11	from	from	IN
cord-006139-9063uhox	74	12	[	[	-LRB-
cord-006139-9063uhox	74	13	19	19	CD
cord-006139-9063uhox	74	14	,	,	,
cord-006139-9063uhox	74	15	20	20	CD
cord-006139-9063uhox	74	16	]	]	-RRB-
cord-006139-9063uhox	74	17	.	.	.
cord-006139-9063uhox	75	1	future	future	JJ
cord-006139-9063uhox	75	2	science	science	NN
cord-006139-9063uhox	75	3	group	group	NN
cord-006139-9063uhox	75	4	is	be	VBZ
cord-006139-9063uhox	75	5	also	also	RB
cord-006139-9063uhox	75	6	evidence	evidence	NN
cord-006139-9063uhox	75	7	that	that	IN
cord-006139-9063uhox	75	8	chloroquine	chloroquine	NN
cord-006139-9063uhox	75	9	causes	cause	VBZ
cord-006139-9063uhox	75	10	a	a	DT
cord-006139-9063uhox	75	11	disruption	disruption	NN
cord-006139-9063uhox	75	12	in	in	IN
cord-006139-9063uhox	75	13	the	the	DT
cord-006139-9063uhox	75	14	growth	growth	NN
cord-006139-9063uhox	75	15	of	of	IN
cord-006139-9063uhox	75	16	the	the	DT
cord-006139-9063uhox	75	17	hemozoin	hemozoin	NNP
cord-006139-9063uhox	75	18	crystals	crystal	NNS
cord-006139-9063uhox	75	19	,	,	,
cord-006139-9063uhox	75	20	which	which	WDT
cord-006139-9063uhox	75	21	show	show	VBP
cord-006139-9063uhox	75	22	evidence	evidence	NN
cord-006139-9063uhox	75	23	of	of	IN
cord-006139-9063uhox	75	24	a	a	DT
cord-006139-9063uhox	75	25	mosaic	mosaic	JJ
cord-006139-9063uhox	75	26	structure	structure	NN
cord-006139-9063uhox	75	27	with	with	IN
cord-006139-9063uhox	75	28	grain	grain	NN
cord-006139-9063uhox	75	29	boundaries	boundary	NNS
cord-006139-9063uhox	75	30	(	(	-LRB-
cord-006139-9063uhox	75	31	Figure	figure	NN
cord-006139-9063uhox	75	32	4C	4c	CD
cord-006139-9063uhox	75	33	)	)	-RRB-
cord-006139-9063uhox	75	34	.	.	.
cord-006139-9063uhox	76	1	Thus	thus	RB
cord-006139-9063uhox	76	2	,	,	,
cord-006139-9063uhox	76	3	in	in	IN
cord-006139-9063uhox	76	4	combination	combination	NN
cord-006139-9063uhox	76	5	with	with	IN
cord-006139-9063uhox	76	6	earlier	early	JJR
cord-006139-9063uhox	76	7	work	work	NN
cord-006139-9063uhox	76	8	,	,	,
cord-006139-9063uhox	76	9	this	this	DT
cord-006139-9063uhox	76	10	study	study	NN
cord-006139-9063uhox	76	11	provided	provide	VBD
cord-006139-9063uhox	76	12	strong	strong	JJ
cord-006139-9063uhox	76	13	evidence	evidence	NN
cord-006139-9063uhox	76	14	that	that	IN
cord-006139-9063uhox	76	15	chloroquine	chloroquine	NN
cord-006139-9063uhox	76	16	does	do	VBZ
cord-006139-9063uhox	76	17	indeed	indeed	RB
cord-006139-9063uhox	76	18	act	act	VB
cord-006139-9063uhox	76	19	by	by	IN
cord-006139-9063uhox	76	20	inhibiting	inhibit	VBG
cord-006139-9063uhox	76	21	hemozoin	hemozoin	NNP
cord-006139-9063uhox	76	22	formation	formation	NN
cord-006139-9063uhox	76	23	in	in	IN
cord-006139-9063uhox	76	24	the	the	DT
cord-006139-9063uhox	76	25	parasite	parasite	NN
cord-006139-9063uhox	76	26	.	.	.
cord-006139-9063uhox	77	1	Preliminary	preliminary	JJ
cord-006139-9063uhox	77	2	evidence	evidence	NN
cord-006139-9063uhox	77	3	also	also	RB
cord-006139-9063uhox	77	4	showed	show	VBD
cord-006139-9063uhox	77	5	an	an	DT
cord-006139-9063uhox	77	6	increase	increase	NN
cord-006139-9063uhox	77	7	in	in	IN
cord-006139-9063uhox	77	8	free	free	JJ
cord-006139-9063uhox	77	9	Fe(III)heme	Fe(III)heme	NNS
cord-006139-9063uhox	77	10	and	and	CC
cord-006139-9063uhox	77	11	a	a	DT
cord-006139-9063uhox	77	12	decrease	decrease	NN
cord-006139-9063uhox	77	13	in	in	IN
cord-006139-9063uhox	77	14	hemozoin	hemozoin	NNP
cord-006139-9063uhox	77	15	at	at	IN
cord-006139-9063uhox	77	16	2.5×	2.5×	CD
cord-006139-9063uhox	77	17	IC	IC	NNP
cord-006139-9063uhox	77	18	50	50	CD
cord-006139-9063uhox	77	19	for	for	IN
cord-006139-9063uhox	77	20	a	a	DT
cord-006139-9063uhox	77	21	number	number	NN
cord-006139-9063uhox	77	22	of	of	IN
cord-006139-9063uhox	77	23	other	other	JJ
cord-006139-9063uhox	77	24	drugs	drug	NNS
cord-006139-9063uhox	77	25	,	,	,
cord-006139-9063uhox	77	26	including	include	VBG
cord-006139-9063uhox	77	27	amodiaquine	amodiaquine	NNP
cord-006139-9063uhox	77	28	,	,	,
cord-006139-9063uhox	77	29	mefloquine	mefloquine	FW
cord-006139-9063uhox	77	30	and	and	CC
cord-006139-9063uhox	77	31	lumefantrine	lumefantrine	NNP
cord-006139-9063uhox	77	32	,	,	,
cord-006139-9063uhox	77	33	as	as	RB
cord-006139-9063uhox	77	34	well	well	RB
cord-006139-9063uhox	77	35	as	as	IN
cord-006139-9063uhox	77	36	artesunate	artesunate	NNP
cord-006139-9063uhox	77	37	.	.	.
cord-006139-9063uhox	78	1	However	however	RB
cord-006139-9063uhox	78	2	,	,	,
cord-006139-9063uhox	78	3	it	-PRON-	PRP
cord-006139-9063uhox	78	4	must	must	MD
cord-006139-9063uhox	78	5	be	be	VB
cord-006139-9063uhox	78	6	emphasized	emphasize	VBN
cord-006139-9063uhox	78	7	that	that	IN
cord-006139-9063uhox	78	8	further	further	JJ
cord-006139-9063uhox	78	9	work	work	NN
cord-006139-9063uhox	78	10	would	would	MD
cord-006139-9063uhox	78	11	be	be	VB
cord-006139-9063uhox	78	12	required	require	VBN
cord-006139-9063uhox	78	13	to	to	TO
cord-006139-9063uhox	78	14	substantiate	substantiate	VB
cord-006139-9063uhox	78	15	whether	whether	IN
cord-006139-9063uhox	78	16	the	the	DT
cord-006139-9063uhox	78	17	observations	observation	NNS
cord-006139-9063uhox	78	18	made	make	VBN
cord-006139-9063uhox	78	19	with	with	IN
cord-006139-9063uhox	78	20	these	these	DT
cord-006139-9063uhox	78	21	other	other	JJ
cord-006139-9063uhox	78	22	drugs	drug	NNS
cord-006139-9063uhox	78	23	are	be	VBP
cord-006139-9063uhox	78	24	causal	causal	JJ
cord-006139-9063uhox	78	25	or	or	CC
cord-006139-9063uhox	78	26	the	the	DT
cord-006139-9063uhox	78	27	effect	effect	NN
cord-006139-9063uhox	78	28	of	of	IN
cord-006139-9063uhox	78	29	inhibiting	inhibit	VBG
cord-006139-9063uhox	78	30	other	other	JJ
cord-006139-9063uhox	78	31	targets	target	NNS
cord-006139-9063uhox	78	32	.	.	.
cord-006139-9063uhox	79	1	Despite	despite	IN
cord-006139-9063uhox	79	2	ongoing	ongoing	JJ
cord-006139-9063uhox	79	3	efforts	effort	NNS
cord-006139-9063uhox	79	4	to	to	TO
cord-006139-9063uhox	79	5	understand	understand	VB
cord-006139-9063uhox	79	6	the	the	DT
cord-006139-9063uhox	79	7	mechanism	mechanism	NN
cord-006139-9063uhox	79	8	of	of	IN
cord-006139-9063uhox	79	9	action	action	NN
cord-006139-9063uhox	79	10	of	of	IN
cord-006139-9063uhox	79	11	4-aminoquinolines	4-aminoquinolines	CD
cord-006139-9063uhox	79	12	and	and	CC
cord-006139-9063uhox	79	13	the	the	DT
cord-006139-9063uhox	79	14	structures	structure	NNS
cord-006139-9063uhox	79	15	of	of	IN
cord-006139-9063uhox	79	16	their	-PRON-	PRP$
cord-006139-9063uhox	79	17	complexes	complex	NNS
cord-006139-9063uhox	79	18	with	with	IN
cord-006139-9063uhox	79	19	Fe(III)heme	fe(iii)heme	CD
cord-006139-9063uhox	79	20	,	,	,
cord-006139-9063uhox	79	21	the	the	DT
cord-006139-9063uhox	79	22	existence	existence	NN
cord-006139-9063uhox	79	23	of	of	IN
cord-006139-9063uhox	79	24	structure	structure	NN
cord-006139-9063uhox	79	25	-	-	HYPH
cord-006139-9063uhox	79	26	activity	activity	NN
cord-006139-9063uhox	79	27	relationship	relationship	NN
cord-006139-9063uhox	79	28	data	datum	NNS
cord-006139-9063uhox	79	29	has	have	VBZ
cord-006139-9063uhox	79	30	substantially	substantially	RB
cord-006139-9063uhox	79	31	aided	aid	VBN
cord-006139-9063uhox	79	32	the	the	DT
cord-006139-9063uhox	79	33	task	task	NN
cord-006139-9063uhox	79	34	of	of	IN
cord-006139-9063uhox	79	35	designing	design	VBG
cord-006139-9063uhox	79	36	new	new	JJ
cord-006139-9063uhox	79	37	compounds	compound	NNS
cord-006139-9063uhox	79	38	in	in	IN
cord-006139-9063uhox	79	39	this	this	DT
cord-006139-9063uhox	79	40	class	class	NN
cord-006139-9063uhox	79	41	.	.	.
cord-006139-9063uhox	80	1	Four	four	CD
cord-006139-9063uhox	80	2	studies	study	NNS
cord-006139-9063uhox	80	3	in	in	IN
cord-006139-9063uhox	80	4	the	the	DT
cord-006139-9063uhox	80	5	late	late	JJ
cord-006139-9063uhox	80	6	1990s	1990	NNS
cord-006139-9063uhox	80	7	and	and	CC
cord-006139-9063uhox	80	8	early	early	JJ
cord-006139-9063uhox	80	9	2000s	2000	NNS
cord-006139-9063uhox	80	10	provided	provide	VBD
cord-006139-9063uhox	80	11	a	a	DT
cord-006139-9063uhox	80	12	detailed	detailed	JJ
cord-006139-9063uhox	80	13	structure	structure	NN
cord-006139-9063uhox	80	14	-	-	HYPH
cord-006139-9063uhox	80	15	activity	activity	NN
cord-006139-9063uhox	80	16	model	model	NN
cord-006139-9063uhox	80	17	for	for	IN
cord-006139-9063uhox	80	18	the	the	DT
cord-006139-9063uhox	80	19	4-aminoquinolines	4-aminoquinolines	CD
cord-006139-9063uhox	80	20	[	[	-LRB-
cord-006139-9063uhox	80	21	42	42	CD
cord-006139-9063uhox	80	22	]	]	-RRB-
cord-006139-9063uhox	80	23	[	[	-LRB-
cord-006139-9063uhox	80	24	43	43	CD
cord-006139-9063uhox	80	25	]	]	-RRB-
cord-006139-9063uhox	80	26	[	[	-LRB-
cord-006139-9063uhox	80	27	44	44	CD
cord-006139-9063uhox	80	28	]	]	-RRB-
cord-006139-9063uhox	80	29	[	[	-LRB-
cord-006139-9063uhox	80	30	45	45	CD
cord-006139-9063uhox	80	31	]	]	-RRB-
cord-006139-9063uhox	80	32	.	.	.
cord-006139-9063uhox	81	1	This	this	DT
cord-006139-9063uhox	81	2	is	be	VBZ
cord-006139-9063uhox	81	3	summarized	summarize	VBN
cord-006139-9063uhox	81	4	in	in	IN
cord-006139-9063uhox	81	5	Figure	Figure	NNP
cord-006139-9063uhox	81	6	5	5	CD
cord-006139-9063uhox	81	7	.	.	.
cord-006139-9063uhox	82	1	Further	further	JJ
cord-006139-9063uhox	82	2	studies	study	NNS
cord-006139-9063uhox	82	3	have	have	VBP
cord-006139-9063uhox	82	4	revealed	reveal	VBN
cord-006139-9063uhox	82	5	that	that	IN
cord-006139-9063uhox	82	6	alterations	alteration	NNS
cord-006139-9063uhox	82	7	to	to	IN
cord-006139-9063uhox	82	8	the	the	DT
cord-006139-9063uhox	82	9	alkyl	alkyl	JJ
cord-006139-9063uhox	82	10	side	side	NN
cord-006139-9063uhox	82	11	chain	chain	NN
cord-006139-9063uhox	82	12	of	of	IN
cord-006139-9063uhox	82	13	the	the	DT
cord-006139-9063uhox	82	14	quinoline	quinoline	NN
cord-006139-9063uhox	82	15	can	can	MD
cord-006139-9063uhox	82	16	abolish	abolish	VB
cord-006139-9063uhox	82	17	cross	cross	NN
cord-006139-9063uhox	82	18	-	-	NN
cord-006139-9063uhox	82	19	resistance	resistance	NN
cord-006139-9063uhox	82	20	with	with	IN
cord-006139-9063uhox	82	21	chloroquine	chloroquine	NN
cord-006139-9063uhox	82	22	[	[	-LRB-
cord-006139-9063uhox	82	23	46	46	CD
cord-006139-9063uhox	82	24	]	]	-RRB-
cord-006139-9063uhox	82	25	.	.	.
cord-006139-9063uhox	83	1	Indeed	indeed	RB
cord-006139-9063uhox	83	2	,	,	,
cord-006139-9063uhox	83	3	the	the	DT
cord-006139-9063uhox	83	4	structure	structure	NN
cord-006139-9063uhox	83	5	of	of	IN
cord-006139-9063uhox	83	6	the	the	DT
cord-006139-9063uhox	83	7	side	side	NN
cord-006139-9063uhox	83	8	chain	chain	NN
cord-006139-9063uhox	83	9	appears	appear	VBZ
cord-006139-9063uhox	83	10	to	to	TO
cord-006139-9063uhox	83	11	be	be	VB
cord-006139-9063uhox	83	12	the	the	DT
cord-006139-9063uhox	83	13	primary	primary	JJ
cord-006139-9063uhox	83	14	determinant	determinant	NN
cord-006139-9063uhox	83	15	of	of	IN
cord-006139-9063uhox	83	16	resistance	resistance	NN
cord-006139-9063uhox	83	17	,	,	,
cord-006139-9063uhox	83	18	with	with	IN
cord-006139-9063uhox	83	19	the	the	DT
cord-006139-9063uhox	83	20	quinoline	quinoline	NN
cord-006139-9063uhox	83	21	ring	ring	NN
cord-006139-9063uhox	83	22	itself	-PRON-	PRP
cord-006139-9063uhox	83	23	having	have	VBG
cord-006139-9063uhox	83	24	,	,	,
cord-006139-9063uhox	83	25	at	at	IN
cord-006139-9063uhox	83	26	most	most	JJS
cord-006139-9063uhox	83	27	,	,	,
cord-006139-9063uhox	83	28	a	a	DT
cord-006139-9063uhox	83	29	minor	minor	JJ
cord-006139-9063uhox	83	30	role	role	NN
cord-006139-9063uhox	83	31	in	in	IN
cord-006139-9063uhox	83	32	cross	cross	NN
cord-006139-9063uhox	83	33	-	-	NN
cord-006139-9063uhox	83	34	resistance	resistance	NN
cord-006139-9063uhox	83	35	[	[	-LRB-
cord-006139-9063uhox	83	36	47	47	CD
cord-006139-9063uhox	83	37	]	]	-RRB-
cord-006139-9063uhox	84	1	[	[	-LRB-
cord-006139-9063uhox	84	2	48	48	CD
cord-006139-9063uhox	84	3	]	]	-RRB-
cord-006139-9063uhox	84	4	[	[	-LRB-
cord-006139-9063uhox	84	5	49	49	CD
cord-006139-9063uhox	84	6	]	]	-RRB-
cord-006139-9063uhox	84	7	.	.	.
cord-006139-9063uhox	85	1	This	this	DT
cord-006139-9063uhox	85	2	has	have	VBZ
cord-006139-9063uhox	85	3	encouraged	encourage	VBN
cord-006139-9063uhox	85	4	the	the	DT
cord-006139-9063uhox	85	5	design	design	NN
cord-006139-9063uhox	85	6	of	of	IN
cord-006139-9063uhox	85	7	new	new	JJ
cord-006139-9063uhox	85	8	quinoline	quinoline	JJ
cord-006139-9063uhox	85	9	antimalarials	antimalarial	NNS
cord-006139-9063uhox	85	10	with	with	IN
cord-006139-9063uhox	85	11	the	the	DT
cord-006139-9063uhox	85	12	aim	aim	NN
cord-006139-9063uhox	85	13	of	of	IN
cord-006139-9063uhox	85	14	overcoming	overcome	VBG
cord-006139-9063uhox	85	15	resistance	resistance	NN
cord-006139-9063uhox	85	16	.	.	.
cord-006139-9063uhox	86	1	As	as	IN
cord-006139-9063uhox	86	2	mentioned	mention	VBN
cord-006139-9063uhox	86	3	above	above	RB
cord-006139-9063uhox	86	4	,	,	,
cord-006139-9063uhox	86	5	P.	p.	NN
cord-006139-9063uhox	86	6	falciparum	falciparum	NN
cord-006139-9063uhox	86	7	that	that	WDT
cord-006139-9063uhox	86	8	are	be	VBP
cord-006139-9063uhox	86	9	resistant	resistant	JJ
cord-006139-9063uhox	86	10	to	to	IN
cord-006139-9063uhox	86	11	chloroquine	chloroquine	NN
cord-006139-9063uhox	86	12	or	or	CC
cord-006139-9063uhox	86	13	other	other	JJ
cord-006139-9063uhox	86	14	quinolines	quinoline	NNS
cord-006139-9063uhox	86	15	exhibit	exhibit	VBP
cord-006139-9063uhox	86	16	no	no	DT
cord-006139-9063uhox	86	17	known	know	VBN
cord-006139-9063uhox	86	18	changes	change	NNS
cord-006139-9063uhox	86	19	in	in	IN
cord-006139-9063uhox	86	20	the	the	DT
cord-006139-9063uhox	86	21	process	process	NN
cord-006139-9063uhox	86	22	of	of	IN
cord-006139-9063uhox	86	23	heme	heme	NN
cord-006139-9063uhox	86	24	detoxification	detoxification	NN
cord-006139-9063uhox	86	25	.	.	.
cord-006139-9063uhox	87	1	Rather	rather	RB
cord-006139-9063uhox	87	2	,	,	,
cord-006139-9063uhox	87	3	resistance	resistance	NN
cord-006139-9063uhox	87	4	arises	arise	VBZ
cord-006139-9063uhox	87	5	from	from	IN
cord-006139-9063uhox	87	6	mutations	mutation	NNS
cord-006139-9063uhox	87	7	and	and	CC
cord-006139-9063uhox	87	8	changes	change	NNS
cord-006139-9063uhox	87	9	in	in	IN
cord-006139-9063uhox	87	10	expression	expression	NN
cord-006139-9063uhox	87	11	levels	level	NNS
cord-006139-9063uhox	87	12	of	of	IN
cord-006139-9063uhox	87	13	membrane	membrane	NN
cord-006139-9063uhox	87	14	proteins	protein	NNS
cord-006139-9063uhox	87	15	located	locate	VBN
cord-006139-9063uhox	87	16	in	in	IN
cord-006139-9063uhox	87	17	the	the	DT
cord-006139-9063uhox	87	18	DV	DV	NNP
cord-006139-9063uhox	87	19	membrane	membrane	NN
cord-006139-9063uhox	87	20	.	.	.
cord-006139-9063uhox	88	1	The	the	DT
cord-006139-9063uhox	88	2	principal	principal	JJ
cord-006139-9063uhox	88	3	determinants	determinant	NNS
cord-006139-9063uhox	88	4	of	of	IN
cord-006139-9063uhox	88	5	chloroquine	chloroquine	NN
cord-006139-9063uhox	88	6	resistance	resistance	NN
cord-006139-9063uhox	88	7	are	be	VBP
cord-006139-9063uhox	88	8	mutant	mutant	JJ
cord-006139-9063uhox	88	9	forms	form	NNS
cord-006139-9063uhox	88	10	of	of	IN
cord-006139-9063uhox	88	11	a	a	DT
cord-006139-9063uhox	88	12	protein	protein	NN
cord-006139-9063uhox	88	13	known	know	VBN
cord-006139-9063uhox	88	14	as	as	IN
cord-006139-9063uhox	88	15	PfCRT	PfCRT	NNP
cord-006139-9063uhox	88	16	[	[	-LRB-
cord-006139-9063uhox	88	17	50	50	CD
cord-006139-9063uhox	88	18	,	,	,
cord-006139-9063uhox	88	19	51	51	CD
cord-006139-9063uhox	88	20	]	]	-RRB-
cord-006139-9063uhox	88	21	.	.	.
cord-006139-9063uhox	89	1	A	a	DT
cord-006139-9063uhox	89	2	second	second	JJ
cord-006139-9063uhox	89	3	protein	protein	NN
cord-006139-9063uhox	89	4	,	,	,
cord-006139-9063uhox	89	5	PfMDR1	PfMDR1	NNP
cord-006139-9063uhox	89	6	,	,	,
cord-006139-9063uhox	89	7	has	have	VBZ
cord-006139-9063uhox	89	8	also	also	RB
cord-006139-9063uhox	89	9	been	be	VBN
cord-006139-9063uhox	89	10	implicated	implicate	VBN
cord-006139-9063uhox	89	11	in	in	IN
cord-006139-9063uhox	89	12	resistance	resistance	NN
cord-006139-9063uhox	89	13	to	to	IN
cord-006139-9063uhox	89	14	quinoline	quinoline	JJ
cord-006139-9063uhox	89	15	antimalarials	antimalarial	NNS
cord-006139-9063uhox	89	16	[	[	-LRB-
cord-006139-9063uhox	89	17	52	52	CD
cord-006139-9063uhox	89	18	,	,	,
cord-006139-9063uhox	89	19	53	53	CD
cord-006139-9063uhox	89	20	]	]	-RRB-
cord-006139-9063uhox	89	21	.	.	.
cord-006139-9063uhox	90	1	Mutations	mutation	NNS
cord-006139-9063uhox	90	2	in	in	IN
cord-006139-9063uhox	90	3	this	this	DT
cord-006139-9063uhox	90	4	protein	protein	NN
cord-006139-9063uhox	90	5	are	be	VBP
cord-006139-9063uhox	90	6	associated	associate	VBN
cord-006139-9063uhox	90	7	future	future	JJ
cord-006139-9063uhox	90	8	science	science	NN
cord-006139-9063uhox	90	9	group	group	NN
cord-006139-9063uhox	90	10	with	with	IN
cord-006139-9063uhox	90	11	mefloquine	mefloquine	NNP
cord-006139-9063uhox	90	12	resistance	resistance	NN
cord-006139-9063uhox	90	13	in	in	IN
cord-006139-9063uhox	90	14	field	field	NN
cord-006139-9063uhox	90	15	isolates	isolate	NNS
cord-006139-9063uhox	90	16	,	,	,
cord-006139-9063uhox	90	17	and	and	CC
cord-006139-9063uhox	90	18	an	an	DT
cord-006139-9063uhox	90	19	increased	increase	VBN
cord-006139-9063uhox	90	20	copy	copy	NN
cord-006139-9063uhox	90	21	number	number	NN
cord-006139-9063uhox	90	22	has	have	VBZ
cord-006139-9063uhox	90	23	previously	previously	RB
cord-006139-9063uhox	90	24	been	be	VBN
cord-006139-9063uhox	90	25	associated	associate	VBN
cord-006139-9063uhox	90	26	with	with	IN
cord-006139-9063uhox	90	27	decreased	decreased	JJ
cord-006139-9063uhox	90	28	sensitivity	sensitivity	NN
cord-006139-9063uhox	90	29	to	to	IN
cord-006139-9063uhox	90	30	quinine	quinine	NN
cord-006139-9063uhox	90	31	.	.	.
cord-006139-9063uhox	91	1	PfMDR1	PfMDR1	NNP
cord-006139-9063uhox	91	2	is	be	VBZ
cord-006139-9063uhox	91	3	not	not	RB
cord-006139-9063uhox	91	4	thought	think	VBN
cord-006139-9063uhox	91	5	to	to	TO
cord-006139-9063uhox	91	6	be	be	VB
cord-006139-9063uhox	91	7	directly	directly	RB
cord-006139-9063uhox	91	8	responsible	responsible	JJ
cord-006139-9063uhox	91	9	for	for	IN
cord-006139-9063uhox	91	10	chloroquine	chloroquine	NN
cord-006139-9063uhox	91	11	resistance	resistance	NN
cord-006139-9063uhox	91	12	,	,	,
cord-006139-9063uhox	91	13	but	but	CC
cord-006139-9063uhox	91	14	mutant	mutant	JJ
cord-006139-9063uhox	91	15	forms	form	NNS
cord-006139-9063uhox	91	16	of	of	IN
cord-006139-9063uhox	91	17	this	this	DT
cord-006139-9063uhox	91	18	protein	protein	NN
cord-006139-9063uhox	91	19	can	can	MD
cord-006139-9063uhox	91	20	affect	affect	VB
cord-006139-9063uhox	91	21	chloroquine	chloroquine	NN
cord-006139-9063uhox	91	22	sensitivity	sensitivity	NN
cord-006139-9063uhox	91	23	in	in	IN
cord-006139-9063uhox	91	24	the	the	DT
cord-006139-9063uhox	91	25	presence	presence	NN
cord-006139-9063uhox	91	26	of	of	IN
cord-006139-9063uhox	91	27	mutant	mutant	JJ
cord-006139-9063uhox	91	28	forms	form	NNS
cord-006139-9063uhox	91	29	of	of	IN
cord-006139-9063uhox	91	30	PfCRT	PfCRT	NNP
cord-006139-9063uhox	91	31	[	[	-LRB-
cord-006139-9063uhox	91	32	54	54	CD
cord-006139-9063uhox	91	33	]	]	-RRB-
cord-006139-9063uhox	91	34	,	,	,
cord-006139-9063uhox	91	35	and	and	CC
cord-006139-9063uhox	91	36	there	there	EX
cord-006139-9063uhox	91	37	is	be	VBZ
cord-006139-9063uhox	91	38	evidence	evidence	NN
cord-006139-9063uhox	91	39	of	of	IN
cord-006139-9063uhox	91	40	a	a	DT
cord-006139-9063uhox	91	41	complex	complex	JJ
cord-006139-9063uhox	91	42	interaction	interaction	NN
cord-006139-9063uhox	91	43	between	between	IN
cord-006139-9063uhox	91	44	PfCRT	PfCRT	NNP
cord-006139-9063uhox	91	45	and	and	CC
cord-006139-9063uhox	91	46	PfMDR1	PfMDR1	NNP
cord-006139-9063uhox	91	47	[	[	-LRB-
cord-006139-9063uhox	91	48	55	55	CD
cord-006139-9063uhox	91	49	]	]	-RRB-
cord-006139-9063uhox	91	50	.	.	.
cord-006139-9063uhox	92	1	In	in	IN
cord-006139-9063uhox	92	2	addition	addition	NN
cord-006139-9063uhox	92	3	,	,	,
cord-006139-9063uhox	92	4	PfMDR1	PfMDR1	NNP
cord-006139-9063uhox	92	5	has	have	VBZ
cord-006139-9063uhox	92	6	recently	recently	RB
cord-006139-9063uhox	92	7	been	be	VBN
cord-006139-9063uhox	92	8	implicated	implicate	VBN
cord-006139-9063uhox	92	9	in	in	IN
cord-006139-9063uhox	92	10	the	the	DT
cord-006139-9063uhox	92	11	transport	transport	NN
cord-006139-9063uhox	92	12	of	of	IN
cord-006139-9063uhox	92	13	chloroquine	chloroquine	NN
cord-006139-9063uhox	92	14	and	and	CC
cord-006139-9063uhox	92	15	other	other	JJ
cord-006139-9063uhox	92	16	quinolines	quinoline	NNS
cord-006139-9063uhox	92	17	into	into	IN
cord-006139-9063uhox	92	18	the	the	DT
cord-006139-9063uhox	92	19	parasite	parasite	NN
cord-006139-9063uhox	92	20	DV	dv	NN
cord-006139-9063uhox	92	21	[	[	-LRB-
cord-006139-9063uhox	92	22	56	56	CD
cord-006139-9063uhox	92	23	]	]	-RRB-
cord-006139-9063uhox	92	24	and	and	CC
cord-006139-9063uhox	92	25	has	have	VBZ
cord-006139-9063uhox	92	26	subsequently	subsequently	RB
cord-006139-9063uhox	92	27	also	also	RB
cord-006139-9063uhox	92	28	been	be	VBN
cord-006139-9063uhox	92	29	shown	show	VBN
cord-006139-9063uhox	92	30	to	to	TO
cord-006139-9063uhox	92	31	bind	bind	VB
cord-006139-9063uhox	92	32	to	to	IN
cord-006139-9063uhox	92	33	a	a	DT
cord-006139-9063uhox	92	34	selection	selection	NN
cord-006139-9063uhox	92	35	of	of	IN
cord-006139-9063uhox	92	36	these	these	DT
cord-006139-9063uhox	92	37	drugs	drug	NNS
cord-006139-9063uhox	92	38	[	[	-LRB-
cord-006139-9063uhox	92	39	57	57	CD
cord-006139-9063uhox	92	40	]	]	-RRB-
cord-006139-9063uhox	92	41	.	.	.
cord-006139-9063uhox	93	1	Furthermore	furthermore	RB
cord-006139-9063uhox	93	2	,	,	,
cord-006139-9063uhox	93	3	evidence	evidence	NN
cord-006139-9063uhox	93	4	from	from	IN
cord-006139-9063uhox	93	5	a	a	DT
cord-006139-9063uhox	93	6	cross	cross	NN
cord-006139-9063uhox	93	7	of	of	IN
cord-006139-9063uhox	93	8	two	two	CD
cord-006139-9063uhox	93	9	different	different	JJ
cord-006139-9063uhox	93	10	drug	drug	NN
cord-006139-9063uhox	93	11	-	-	HYPH
cord-006139-9063uhox	93	12	resistant	resistant	JJ
cord-006139-9063uhox	93	13	strains	strain	NNS
cord-006139-9063uhox	93	14	(	(	-LRB-
cord-006139-9063uhox	93	15	GB4	gb4	NN
cord-006139-9063uhox	93	16	and	and	CC
cord-006139-9063uhox	93	17	7G8	7g8	CD
cord-006139-9063uhox	93	18	)	)	-RRB-
cord-006139-9063uhox	93	19	has	have	VBZ
cord-006139-9063uhox	93	20	indicated	indicate	VBN
cord-006139-9063uhox	93	21	that	that	IN
cord-006139-9063uhox	93	22	quinolines	quinoline	NNS
cord-006139-9063uhox	93	23	actually	actually	RB
cord-006139-9063uhox	93	24	inhibit	inhibit	VBP
cord-006139-9063uhox	93	25	transport	transport	NN
cord-006139-9063uhox	93	26	of	of	IN
cord-006139-9063uhox	93	27	the	the	DT
cord-006139-9063uhox	93	28	natural	natural	JJ
cord-006139-9063uhox	93	29	substrates	substrate	NNS
cord-006139-9063uhox	93	30	of	of	IN
cord-006139-9063uhox	94	1	PfCRT	PfCRT	NNP
cord-006139-9063uhox	94	2	and	and	CC
cord-006139-9063uhox	94	3	PGH-1	PGH-1	NNPS
cord-006139-9063uhox	94	4	(	(	-LRB-
cord-006139-9063uhox	94	5	the	the	DT
cord-006139-9063uhox	94	6	protein	protein	NN
cord-006139-9063uhox	94	7	encoded	encode	VBN
cord-006139-9063uhox	94	8	by	by	IN
cord-006139-9063uhox	94	9	PfMDR1	PfMDR1	NNP
cord-006139-9063uhox	94	10	)	)	-RRB-
cord-006139-9063uhox	94	11	[	[	-LRB-
cord-006139-9063uhox	94	12	58	58	CD
cord-006139-9063uhox	94	13	]	]	-RRB-
cord-006139-9063uhox	94	14	.	.	.
cord-006139-9063uhox	95	1	A	a	DT
cord-006139-9063uhox	95	2	third	third	JJ
cord-006139-9063uhox	95	3	protein	protein	NN
cord-006139-9063uhox	95	4	,	,	,
cord-006139-9063uhox	95	5	PfMRP1	PfMRP1	NNP
cord-006139-9063uhox	95	6	,	,	,
cord-006139-9063uhox	95	7	located	locate	VBN
cord-006139-9063uhox	95	8	in	in	IN
cord-006139-9063uhox	95	9	the	the	DT
cord-006139-9063uhox	95	10	parasite	parasite	NN
cord-006139-9063uhox	95	11	plasma	plasma	NN
cord-006139-9063uhox	95	12	membrane	membrane	NN
cord-006139-9063uhox	95	13	,	,	,
cord-006139-9063uhox	95	14	has	have	VBZ
cord-006139-9063uhox	95	15	also	also	RB
cord-006139-9063uhox	95	16	been	be	VBN
cord-006139-9063uhox	95	17	suggested	suggest	VBN
cord-006139-9063uhox	95	18	to	to	TO
cord-006139-9063uhox	95	19	play	play	VB
cord-006139-9063uhox	95	20	a	a	DT
cord-006139-9063uhox	95	21	role	role	NN
cord-006139-9063uhox	95	22	in	in	IN
cord-006139-9063uhox	95	23	chloroquine	chloroquine	NN
cord-006139-9063uhox	95	24	resistance	resistance	NN
cord-006139-9063uhox	95	25	,	,	,
cord-006139-9063uhox	95	26	but	but	CC
cord-006139-9063uhox	95	27	in	in	IN
cord-006139-9063uhox	95	28	this	this	DT
cord-006139-9063uhox	95	29	case	case	NN
cord-006139-9063uhox	95	30	,	,	,
cord-006139-9063uhox	95	31	the	the	DT
cord-006139-9063uhox	95	32	evidence	evidence	NN
cord-006139-9063uhox	95	33	remains	remain	VBZ
cord-006139-9063uhox	95	34	uncertain	uncertain	JJ
cord-006139-9063uhox	95	35	[	[	-LRB-
cord-006139-9063uhox	95	36	59	59	CD
cord-006139-9063uhox	95	37	,	,	,
cord-006139-9063uhox	95	38	60	60	CD
cord-006139-9063uhox	95	39	]	]	-RRB-
cord-006139-9063uhox	95	40	.	.	.
cord-006139-9063uhox	96	1	Notwithstanding	notwithstanding	IN
cord-006139-9063uhox	96	2	the	the	DT
cord-006139-9063uhox	96	3	role	role	NN
cord-006139-9063uhox	96	4	of	of	IN
cord-006139-9063uhox	96	5	these	these	DT
cord-006139-9063uhox	96	6	other	other	JJ
cord-006139-9063uhox	96	7	membrane	membrane	NN
cord-006139-9063uhox	96	8	proteins	protein	NNS
cord-006139-9063uhox	96	9	,	,	,
cord-006139-9063uhox	96	10	a	a	DT
cord-006139-9063uhox	96	11	PfCRT	PfCRT	NNP
cord-006139-9063uhox	96	12	mutation	mutation	NN
cord-006139-9063uhox	96	13	is	be	VBZ
cord-006139-9063uhox	96	14	accepted	accept	VBN
cord-006139-9063uhox	96	15	to	to	TO
cord-006139-9063uhox	96	16	be	be	VB
cord-006139-9063uhox	96	17	the	the	DT
cord-006139-9063uhox	96	18	major	major	JJ
cord-006139-9063uhox	96	19	factor	factor	NN
cord-006139-9063uhox	96	20	involved	involve	VBN
cord-006139-9063uhox	96	21	in	in	IN
cord-006139-9063uhox	96	22	chloroquine	chloroquine	NN
cord-006139-9063uhox	96	23	resistance	resistance	NN
cord-006139-9063uhox	96	24	.	.	.
cord-006139-9063uhox	97	1	PfCRT	PfCRT	NNP
cord-006139-9063uhox	97	2	is	be	VBZ
cord-006139-9063uhox	97	3	predicted	predict	VBN
cord-006139-9063uhox	97	4	to	to	TO
cord-006139-9063uhox	97	5	be	be	VB
cord-006139-9063uhox	97	6	an	an	DT
cord-006139-9063uhox	97	7	integral	integral	JJ
cord-006139-9063uhox	97	8	membrane	membrane	NN
cord-006139-9063uhox	97	9	protein	protein	NN
cord-006139-9063uhox	97	10	localized	localize	VBN
cord-006139-9063uhox	97	11	to	to	IN
cord-006139-9063uhox	97	12	the	the	DT
cord-006139-9063uhox	97	13	DV	DV	NNP
cord-006139-9063uhox	97	14	membrane	membrane	NN
cord-006139-9063uhox	97	15	.	.	.
cord-006139-9063uhox	98	1	It	-PRON-	PRP
cord-006139-9063uhox	98	2	is	be	VBZ
cord-006139-9063uhox	98	3	believed	believe	VBN
cord-006139-9063uhox	98	4	to	to	TO
cord-006139-9063uhox	98	5	be	be	VB
cord-006139-9063uhox	98	6	a	a	DT
cord-006139-9063uhox	98	7	member	member	NN
cord-006139-9063uhox	98	8	of	of	IN
cord-006139-9063uhox	98	9	the	the	DT
cord-006139-9063uhox	98	10	drug	drug	NN
cord-006139-9063uhox	98	11	metabolite	metabolite	NN
cord-006139-9063uhox	98	12	transporter	transporter	NN
cord-006139-9063uhox	98	13	family	family	NN
cord-006139-9063uhox	98	14	of	of	IN
cord-006139-9063uhox	98	15	proteins	protein	NNS
cord-006139-9063uhox	98	16	[	[	-LRB-
cord-006139-9063uhox	98	17	61	61	CD
cord-006139-9063uhox	98	18	]	]	-RRB-
cord-006139-9063uhox	98	19	.	.	.
cord-006139-9063uhox	99	1	Chloroquineresistant	chloroquineresistant	JJ
cord-006139-9063uhox	99	2	strains	strain	NNS
cord-006139-9063uhox	99	3	of	of	IN
cord-006139-9063uhox	99	4	the	the	DT
cord-006139-9063uhox	99	5	parasite	parasite	NN
cord-006139-9063uhox	99	6	exhibit	exhibit	NN
cord-006139-9063uhox	99	7	several	several	JJ
cord-006139-9063uhox	99	8	mutations	mutation	NNS
cord-006139-9063uhox	99	9	in	in	IN
cord-006139-9063uhox	99	10	this	this	DT
cord-006139-9063uhox	99	11	protein	protein	NN
cord-006139-9063uhox	99	12	(	(	-LRB-
cord-006139-9063uhox	99	13	Figure	figure	NN
cord-006139-9063uhox	99	14	6	6	CD
cord-006139-9063uhox	99	15	)	)	-RRB-
cord-006139-9063uhox	100	1	[	[	-LRB-
cord-006139-9063uhox	100	2	62	62	CD
cord-006139-9063uhox	100	3	]	]	-RRB-
cord-006139-9063uhox	100	4	,	,	,
cord-006139-9063uhox	100	5	but	but	CC
cord-006139-9063uhox	101	1	all	all	DT
cord-006139-9063uhox	101	2	naturally	naturally	RB
cord-006139-9063uhox	101	3	occurring	occur	VBG
cord-006139-9063uhox	101	4	chloroquine	chloroquine	NN
cord-006139-9063uhox	101	5	-	-	HYPH
cord-006139-9063uhox	101	6	resistant	resistant	JJ
cord-006139-9063uhox	101	7	mutants	mutant	NNS
cord-006139-9063uhox	101	8	exhibit	exhibit	VBP
cord-006139-9063uhox	101	9	one	one	CD
cord-006139-9063uhox	101	10	crucial	crucial	JJ
cord-006139-9063uhox	101	11	mutation	mutation	NN
cord-006139-9063uhox	101	12	,	,	,
cord-006139-9063uhox	101	13	that	that	DT
cord-006139-9063uhox	101	14	of	of	IN
cord-006139-9063uhox	101	15	Lys-76	lys-76	NN
cord-006139-9063uhox	101	16	to	to	IN
cord-006139-9063uhox	101	17	Thr-76	Thr-76	NNP
cord-006139-9063uhox	101	18	(	(	-LRB-
cord-006139-9063uhox	101	19	K76	K76	NNP
cord-006139-9063uhox	101	20	T	T	NNP
cord-006139-9063uhox	101	21	)	)	-RRB-
cord-006139-9063uhox	101	22	.	.	.
cord-006139-9063uhox	102	1	The	the	DT
cord-006139-9063uhox	102	2	additional	additional	JJ
cord-006139-9063uhox	102	3	mutations	mutation	NNS
cord-006139-9063uhox	102	4	to	to	IN
cord-006139-9063uhox	102	5	K76	K76	NNP
cord-006139-9063uhox	102	6	T	T	NNP
cord-006139-9063uhox	102	7	are	be	VBP
cord-006139-9063uhox	102	8	thought	think	VBN
cord-006139-9063uhox	102	9	to	to	TO
cord-006139-9063uhox	102	10	counteract	counteract	VB
cord-006139-9063uhox	102	11	the	the	DT
cord-006139-9063uhox	102	12	loss	loss	NN
cord-006139-9063uhox	102	13	of	of	IN
cord-006139-9063uhox	102	14	function	function	NN
cord-006139-9063uhox	102	15	that	that	WDT
cord-006139-9063uhox	102	16	would	would	MD
cord-006139-9063uhox	102	17	occur	occur	VB
cord-006139-9063uhox	102	18	in	in	IN
cord-006139-9063uhox	102	19	the	the	DT
cord-006139-9063uhox	102	20	case	case	NN
cord-006139-9063uhox	102	21	of	of	IN
cord-006139-9063uhox	102	22	the	the	DT
cord-006139-9063uhox	102	23	K76	K76	NNP
cord-006139-9063uhox	102	24	T	T	NNP
cord-006139-9063uhox	102	25	mutation	mutation	NN
cord-006139-9063uhox	102	26	alone	alone	RB
cord-006139-9063uhox	102	27	[	[	-LRB-
cord-006139-9063uhox	102	28	63	63	CD
cord-006139-9063uhox	102	29	]	]	-RRB-
cord-006139-9063uhox	102	30	.	.	.
cord-006139-9063uhox	103	1	Studies	study	NNS
cord-006139-9063uhox	103	2	conducted	conduct	VBN
cord-006139-9063uhox	103	3	using	use	VBG
cord-006139-9063uhox	103	4	Xenopus	Xenopus	NNP
cord-006139-9063uhox	103	5	laevis	laevi	NNS
cord-006139-9063uhox	103	6	oocytes	oocyte	NNS
cord-006139-9063uhox	103	7	injected	inject	VBN
cord-006139-9063uhox	103	8	with	with	IN
cord-006139-9063uhox	103	9	mRNA	mrna	NN
cord-006139-9063uhox	103	10	encoding	encode	VBG
cord-006139-9063uhox	103	11	PfCRT	PfCRT	NNP
cord-006139-9063uhox	103	12	have	have	VBP
cord-006139-9063uhox	103	13	convincingly	convincingly	RB
cord-006139-9063uhox	103	14	shown	show	VBN
cord-006139-9063uhox	103	15	that	that	IN
cord-006139-9063uhox	103	16	this	this	DT
cord-006139-9063uhox	103	17	protein	protein	NN
cord-006139-9063uhox	103	18	transports	transport	VBZ
cord-006139-9063uhox	103	19	chloroquine	chloroquine	NN
cord-006139-9063uhox	103	20	.	.	.
cord-006139-9063uhox	104	1	These	these	DT
cord-006139-9063uhox	104	2	findings	finding	NNS
cord-006139-9063uhox	104	3	support	support	VBP
cord-006139-9063uhox	104	4	the	the	DT
cord-006139-9063uhox	104	5	hypothesis	hypothesis	NN
cord-006139-9063uhox	104	6	that	that	WDT
cord-006139-9063uhox	104	7	decreased	decrease	VBD
cord-006139-9063uhox	104	8	activity	activity	NN
cord-006139-9063uhox	104	9	of	of	IN
cord-006139-9063uhox	104	10	chloroquine	chloroquine	NN
cord-006139-9063uhox	104	11	stems	stem	VBZ
cord-006139-9063uhox	104	12	from	from	IN
cord-006139-9063uhox	104	13	its	-PRON-	PRP$
cord-006139-9063uhox	104	14	extrusion	extrusion	NN
cord-006139-9063uhox	104	15	by	by	IN
cord-006139-9063uhox	104	16	PfCRT	PfCRT	NNPS
cord-006139-9063uhox	104	17	from	from	IN
cord-006139-9063uhox	104	18	the	the	DT
cord-006139-9063uhox	104	19	DV	DV	NNP
cord-006139-9063uhox	104	20	.	.	.
cord-006139-9063uhox	105	1	This	this	DT
cord-006139-9063uhox	105	2	effectively	effectively	RB
cord-006139-9063uhox	105	3	lowers	lower	VBZ
cord-006139-9063uhox	105	4	the	the	DT
cord-006139-9063uhox	105	5	concentration	concentration	NN
cord-006139-9063uhox	105	6	of	of	IN
cord-006139-9063uhox	105	7	chloroquine	chloroquine	NN
cord-006139-9063uhox	105	8	in	in	IN
cord-006139-9063uhox	105	9	this	this	DT
cord-006139-9063uhox	105	10	organelle	organelle	NN
cord-006139-9063uhox	105	11	,	,	,
cord-006139-9063uhox	105	12	thus	thus	RB
cord-006139-9063uhox	105	13	permitting	permit	VBG
cord-006139-9063uhox	105	14	hemozoin	hemozoin	NNP
cord-006139-9063uhox	105	15	formation	formation	NN
cord-006139-9063uhox	105	16	to	to	TO
cord-006139-9063uhox	105	17	resume	resume	VB
cord-006139-9063uhox	105	18	unhindered	unhindered	JJ
cord-006139-9063uhox	105	19	[	[	-LRB-
cord-006139-9063uhox	105	20	64	64	CD
cord-006139-9063uhox	105	21	]	]	-RRB-
cord-006139-9063uhox	105	22	.	.	.
cord-006139-9063uhox	106	1	Chloroquine	Chloroquine	NNP
cord-006139-9063uhox	106	2	is	be	VBZ
cord-006139-9063uhox	106	3	also	also	RB
cord-006139-9063uhox	106	4	thought	think	VBN
cord-006139-9063uhox	106	5	to	to	TO
cord-006139-9063uhox	106	6	bind	bind	VB
cord-006139-9063uhox	106	7	to	to	IN
cord-006139-9063uhox	106	8	PfCRT	PfCRT	NNP
cord-006139-9063uhox	106	9	,	,	,
cord-006139-9063uhox	106	10	and	and	CC
cord-006139-9063uhox	106	11	a	a	DT
cord-006139-9063uhox	106	12	possible	possible	JJ
cord-006139-9063uhox	106	13	site	site	NN
cord-006139-9063uhox	106	14	of	of	IN
cord-006139-9063uhox	106	15	interaction	interaction	NN
cord-006139-9063uhox	106	16	has	have	VBZ
cord-006139-9063uhox	106	17	been	be	VBN
cord-006139-9063uhox	106	18	proposed	propose	VBN
cord-006139-9063uhox	106	19	based	base	VBN
cord-006139-9063uhox	106	20	on	on	IN
cord-006139-9063uhox	106	21	photoaffinity	photoaffinity	NN
cord-006139-9063uhox	106	22	labeling	label	VBG
cord-006139-9063uhox	106	23	[	[	-LRB-
cord-006139-9063uhox	106	24	65	65	CD
cord-006139-9063uhox	106	25	]	]	-RRB-
cord-006139-9063uhox	106	26	.	.	.
cord-006139-9063uhox	107	1	Several	several	JJ
cord-006139-9063uhox	107	2	recent	recent	JJ
cord-006139-9063uhox	107	3	and	and	CC
cord-006139-9063uhox	107	4	comprehensive	comprehensive	JJ
cord-006139-9063uhox	107	5	reviews	review	NNS
cord-006139-9063uhox	107	6	covering	cover	VBG
cord-006139-9063uhox	107	7	PfCRT	PfCRT	NNP
cord-006139-9063uhox	107	8	and	and	CC
cord-006139-9063uhox	107	9	chloroquine	chloroquine	NN
cord-006139-9063uhox	107	10	resistance	resistance	NN
cord-006139-9063uhox	107	11	are	be	VBP
cord-006139-9063uhox	107	12	available	available	JJ
cord-006139-9063uhox	107	13	,	,	,
cord-006139-9063uhox	107	14	and	and	CC
cord-006139-9063uhox	107	15	readers	reader	NNS
cord-006139-9063uhox	107	16	are	be	VBP
cord-006139-9063uhox	107	17	encouraged	encourage	VBN
cord-006139-9063uhox	107	18	to	to	TO
cord-006139-9063uhox	107	19	consult	consult	VB
cord-006139-9063uhox	107	20	them	-PRON-	PRP
cord-006139-9063uhox	107	21	for	for	IN
cord-006139-9063uhox	107	22	in	in	IN
cord-006139-9063uhox	107	23	-	-	HYPH
cord-006139-9063uhox	107	24	depth	depth	NN
cord-006139-9063uhox	107	25	discussion	discussion	NN
cord-006139-9063uhox	107	26	[	[	-LRB-
cord-006139-9063uhox	107	27	62	62	CD
cord-006139-9063uhox	107	28	,	,	,
cord-006139-9063uhox	107	29	[	[	-LRB-
cord-006139-9063uhox	107	30	66	66	CD
cord-006139-9063uhox	107	31	]	]	-RRB-
cord-006139-9063uhox	108	1	[	[	-LRB-
cord-006139-9063uhox	108	2	67	67	CD
cord-006139-9063uhox	108	3	]	]	-RRB-
cord-006139-9063uhox	108	4	[	[	-LRB-
cord-006139-9063uhox	108	5	68	68	CD
cord-006139-9063uhox	108	6	]	]	-RRB-
cord-006139-9063uhox	108	7	.	.	.
cord-006139-9063uhox	109	1	It	-PRON-	PRP
cord-006139-9063uhox	109	2	has	have	VBZ
cord-006139-9063uhox	109	3	been	be	VBN
cord-006139-9063uhox	109	4	known	know	VBN
cord-006139-9063uhox	109	5	for	for	IN
cord-006139-9063uhox	109	6	two	two	CD
cord-006139-9063uhox	109	7	and	and	CC
cord-006139-9063uhox	109	8	a	a	DT
cord-006139-9063uhox	109	9	half	half	NN
cord-006139-9063uhox	109	10	decades	decade	NNS
cord-006139-9063uhox	109	11	that	that	WDT
cord-006139-9063uhox	109	12	verapamil	verapamil	NN
cord-006139-9063uhox	109	13	,	,	,
cord-006139-9063uhox	109	14	a	a	DT
cord-006139-9063uhox	109	15	calcium	calcium	NN
cord-006139-9063uhox	109	16	channel	channel	NN
cord-006139-9063uhox	109	17	blocker	blocker	NN
cord-006139-9063uhox	109	18	,	,	,
cord-006139-9063uhox	109	19	can	can	MD
cord-006139-9063uhox	109	20	restore	restore	VB
cord-006139-9063uhox	109	21	the	the	DT
cord-006139-9063uhox	109	22	activity	activity	NN
cord-006139-9063uhox	109	23	of	of	IN
cord-006139-9063uhox	109	24	chloroquine	chloroquine	NN
cord-006139-9063uhox	109	25	in	in	IN
cord-006139-9063uhox	109	26	several	several	JJ
cord-006139-9063uhox	109	27	resistant	resistant	JJ
cord-006139-9063uhox	109	28	laboratory	laboratory	NN
cord-006139-9063uhox	109	29	strains	strain	NNS
cord-006139-9063uhox	109	30	of	of	IN
cord-006139-9063uhox	109	31	P.	P.	NNP
cord-006139-9063uhox	109	32	falciparum	falciparum	NN
cord-006139-9063uhox	109	33	[	[	-LRB-
cord-006139-9063uhox	109	34	69	69	CD
cord-006139-9063uhox	109	35	,	,	,
cord-006139-9063uhox	109	36	70	70	CD
cord-006139-9063uhox	109	37	]	]	-RRB-
cord-006139-9063uhox	109	38	.	.	.
cord-006139-9063uhox	110	1	Subsequent	subsequent	JJ
cord-006139-9063uhox	110	2	to	to	IN
cord-006139-9063uhox	110	3	this	this	DT
cord-006139-9063uhox	110	4	initial	initial	JJ
cord-006139-9063uhox	110	5	discovery	discovery	NN
cord-006139-9063uhox	110	6	,	,	,
cord-006139-9063uhox	110	7	many	many	JJ
cord-006139-9063uhox	110	8	other	other	JJ
cord-006139-9063uhox	110	9	compounds	compound	NNS
cord-006139-9063uhox	110	10	have	have	VBP
cord-006139-9063uhox	110	11	been	be	VBN
cord-006139-9063uhox	110	12	found	find	VBN
cord-006139-9063uhox	110	13	to	to	TO
cord-006139-9063uhox	110	14	have	have	VB
cord-006139-9063uhox	110	15	similar	similar	JJ
cord-006139-9063uhox	110	16	chemosensitizing	chemosensitizing	NN
cord-006139-9063uhox	110	17	properties	property	NNS
cord-006139-9063uhox	110	18	.	.	.
cord-006139-9063uhox	111	1	These	these	DT
cord-006139-9063uhox	111	2	include	include	VBP
cord-006139-9063uhox	111	3	other	other	JJ
cord-006139-9063uhox	111	4	calcium	calcium	NN
cord-006139-9063uhox	111	5	channel	channel	NN
cord-006139-9063uhox	111	6	blockers	blocker	NNS
cord-006139-9063uhox	111	7	,	,	,
cord-006139-9063uhox	111	8	including	include	VBG
cord-006139-9063uhox	111	9	analogs	analog	NNS
cord-006139-9063uhox	111	10	of	of	IN
cord-006139-9063uhox	111	11	verapamil	verapamil	NN
cord-006139-9063uhox	111	12	and	and	CC
cord-006139-9063uhox	111	13	nifedipine	nifedipine	NN
cord-006139-9063uhox	111	14	;	;	:
cord-006139-9063uhox	111	15	dibenzazepines	dibenzazepine	NNS
cord-006139-9063uhox	111	16	and	and	CC
cord-006139-9063uhox	111	17	their	-PRON-	PRP$
cord-006139-9063uhox	111	18	analogs	analog	NNS
cord-006139-9063uhox	111	19	,	,	,
cord-006139-9063uhox	111	20	which	which	WDT
cord-006139-9063uhox	111	21	include	include	VBP
cord-006139-9063uhox	111	22	imipramine	imipramine	NN
cord-006139-9063uhox	111	23	;	;	:
cord-006139-9063uhox	111	24	phenothiazines	phenothiazines	NNP
cord-006139-9063uhox	111	25	;	;	:
cord-006139-9063uhox	111	26	dihydroanthracenes	dihydroanthracenes	NNPS
cord-006139-9063uhox	111	27	;	;	:
cord-006139-9063uhox	111	28	dibenzylmethylamines	dibenzylmethylamines	NNP
cord-006139-9063uhox	111	29	(	(	-LRB-
cord-006139-9063uhox	111	30	dibemethins	dibemethins	NNP
cord-006139-9063uhox	111	31	)	)	-RRB-
cord-006139-9063uhox	111	32	;	;	:
cord-006139-9063uhox	111	33	plant	plant	NN
cord-006139-9063uhox	111	34	-	-	HYPH
cord-006139-9063uhox	111	35	derived	derive	VBN
cord-006139-9063uhox	111	36	alkaloids	alkaloid	NNS
cord-006139-9063uhox	111	37	;	;	:
cord-006139-9063uhox	111	38	and	and	CC
cord-006139-9063uhox	111	39	others	other	NNS
cord-006139-9063uhox	111	40	,	,	,
cord-006139-9063uhox	111	41	including	include	VBG
cord-006139-9063uhox	111	42	primaquine	primaquine	NN
cord-006139-9063uhox	111	43	[	[	-LRB-
cord-006139-9063uhox	111	44	71	71	CD
cord-006139-9063uhox	111	45	]	]	-RRB-
cord-006139-9063uhox	111	46	.	.	.
cord-006139-9063uhox	112	1	A	a	DT
cord-006139-9063uhox	112	2	common	common	JJ
cord-006139-9063uhox	112	3	feature	feature	NN
cord-006139-9063uhox	112	4	of	of	IN
cord-006139-9063uhox	112	5	nearly	nearly	RB
cord-006139-9063uhox	112	6	all	all	DT
cord-006139-9063uhox	112	7	of	of	IN
cord-006139-9063uhox	112	8	these	these	DT
cord-006139-9063uhox	112	9	compounds	compound	NNS
cord-006139-9063uhox	112	10	is	be	VBZ
cord-006139-9063uhox	112	11	a	a	DT
cord-006139-9063uhox	112	12	basic	basic	JJ
cord-006139-9063uhox	112	13	amino	amino	NN
cord-006139-9063uhox	112	14	group	group	NN
cord-006139-9063uhox	112	15	that	that	WDT
cord-006139-9063uhox	112	16	is	be	VBZ
cord-006139-9063uhox	112	17	expected	expect	VBN
cord-006139-9063uhox	112	18	to	to	TO
cord-006139-9063uhox	112	19	be	be	VB
cord-006139-9063uhox	112	20	protonated	protonate	VBN
cord-006139-9063uhox	112	21	at	at	IN
cord-006139-9063uhox	112	22	the	the	DT
cord-006139-9063uhox	112	23	pH	ph	NN
cord-006139-9063uhox	112	24	of	of	IN
cord-006139-9063uhox	112	25	the	the	DT
cord-006139-9063uhox	112	26	parasite	parasite	NN
cord-006139-9063uhox	112	27	DV	DV	NNP
cord-006139-9063uhox	112	28	.	.	.
cord-006139-9063uhox	113	1	These	these	DT
cord-006139-9063uhox	113	2	compounds	compound	NNS
cord-006139-9063uhox	113	3	are	be	VBP
cord-006139-9063uhox	113	4	believed	believe	VBN
cord-006139-9063uhox	113	5	to	to	TO
cord-006139-9063uhox	113	6	act	act	VB
cord-006139-9063uhox	113	7	by	by	IN
cord-006139-9063uhox	113	8	inhibiting	inhibit	VBG
cord-006139-9063uhox	113	9	chloroquine	chloroquine	NN
cord-006139-9063uhox	113	10	transport	transport	NN
cord-006139-9063uhox	113	11	by	by	IN
cord-006139-9063uhox	113	12	PfCRT	PfCRT	NNP
cord-006139-9063uhox	113	13	,	,	,
cord-006139-9063uhox	113	14	and	and	CC
cord-006139-9063uhox	113	15	this	this	DT
cord-006139-9063uhox	113	16	has	have	VBZ
cord-006139-9063uhox	113	17	been	be	VBN
cord-006139-9063uhox	113	18	directly	directly	RB
cord-006139-9063uhox	113	19	demonstrated	demonstrate	VBN
cord-006139-9063uhox	113	20	in	in	IN
cord-006139-9063uhox	113	21	the	the	DT
cord-006139-9063uhox	113	22	case	case	NN
cord-006139-9063uhox	113	23	of	of	IN
cord-006139-9063uhox	113	24	verapamil	verapamil	NN
cord-006139-9063uhox	113	25	,	,	,
cord-006139-9063uhox	113	26	primaquine	primaquine	NN
cord-006139-9063uhox	113	27	and	and	CC
cord-006139-9063uhox	113	28	several	several	JJ
cord-006139-9063uhox	113	29	dibemethins	dibemethin	NNS
cord-006139-9063uhox	113	30	in	in	IN
cord-006139-9063uhox	113	31	the	the	DT
cord-006139-9063uhox	113	32	Xenopus	Xenopus	NNP
cord-006139-9063uhox	113	33	oocyte	oocyte	NN
cord-006139-9063uhox	113	34	system	system	NN
cord-006139-9063uhox	113	35	[	[	-LRB-
cord-006139-9063uhox	113	36	64	64	CD
cord-006139-9063uhox	113	37	,	,	,
cord-006139-9063uhox	113	38	72	72	CD
cord-006139-9063uhox	113	39	]	]	-RRB-
cord-006139-9063uhox	113	40	.	.	.
cord-006139-9063uhox	114	1	It	-PRON-	PRP
cord-006139-9063uhox	114	2	is	be	VBZ
cord-006139-9063uhox	114	3	not	not	RB
cord-006139-9063uhox	114	4	known	know	VBN
cord-006139-9063uhox	114	5	whether	whether	IN
cord-006139-9063uhox	114	6	these	these	DT
cord-006139-9063uhox	114	7	compounds	compound	NNS
cord-006139-9063uhox	114	8	act	act	VBP
cord-006139-9063uhox	114	9	as	as	IN
cord-006139-9063uhox	114	10	competitive	competitive	JJ
cord-006139-9063uhox	114	11	or	or	CC
cord-006139-9063uhox	114	12	noncompetitive	noncompetitive	JJ
cord-006139-9063uhox	114	13	inhibitors	inhibitor	NNS
cord-006139-9063uhox	114	14	of	of	IN
cord-006139-9063uhox	114	15	chloroquine	chloroquine	NN
cord-006139-9063uhox	114	16	transport	transport	NN
cord-006139-9063uhox	114	17	.	.	.
cord-006139-9063uhox	115	1	Two	two	CD
cord-006139-9063uhox	115	2	significant	significant	JJ
cord-006139-9063uhox	115	3	quantitative	quantitative	JJ
cord-006139-9063uhox	115	4	structure	structure	NN
cord-006139-9063uhox	115	5	-	-	HYPH
cord-006139-9063uhox	115	6	activity	activity	NN
cord-006139-9063uhox	115	7	relationship	relationship	NN
cord-006139-9063uhox	115	8	studies	study	NNS
cord-006139-9063uhox	115	9	have	have	VBP
cord-006139-9063uhox	115	10	been	be	VBN
cord-006139-9063uhox	115	11	carried	carry	VBN
cord-006139-9063uhox	115	12	out	out	RP
cord-006139-9063uhox	115	13	on	on	IN
cord-006139-9063uhox	115	14	chloroquine	chloroquine	NN
cord-006139-9063uhox	115	15	chemosensitizers	chemosensitizer	NNS
cord-006139-9063uhox	115	16	.	.	.
cord-006139-9063uhox	116	1	One	one	CD
cord-006139-9063uhox	116	2	exclusively	exclusively	RB
cord-006139-9063uhox	116	3	investigated	investigate	VBD
cord-006139-9063uhox	116	4	a	a	DT
cord-006139-9063uhox	116	5	series	series	NN
cord-006139-9063uhox	116	6	of	of	IN
cord-006139-9063uhox	116	7	dihydroanthracene	dihydroanthracene	JJ
cord-006139-9063uhox	116	8	derivatives	derivative	NNS
cord-006139-9063uhox	116	9	with	with	IN
cord-006139-9063uhox	116	10	rigid	rigid	JJ
cord-006139-9063uhox	116	11	bicyclic	bicyclic	JJ
cord-006139-9063uhox	116	12	structures	structure	NNS
cord-006139-9063uhox	116	13	[	[	-LRB-
cord-006139-9063uhox	116	14	73	73	CD
cord-006139-9063uhox	116	15	]	]	-RRB-
cord-006139-9063uhox	116	16	.	.	.
cord-006139-9063uhox	117	1	Based	base	VBN
cord-006139-9063uhox	117	2	on	on	IN
cord-006139-9063uhox	117	3	this	this	DT
cord-006139-9063uhox	117	4	study	study	NN
cord-006139-9063uhox	117	5	,	,	,
cord-006139-9063uhox	117	6	the	the	DT
cord-006139-9063uhox	117	7	authors	author	NNS
cord-006139-9063uhox	117	8	suggested	suggest	VBD
cord-006139-9063uhox	117	9	that	that	IN
cord-006139-9063uhox	117	10	these	these	DT
cord-006139-9063uhox	117	11	molecules	molecule	NNS
cord-006139-9063uhox	117	12	interact	interact	VBP
cord-006139-9063uhox	117	13	with	with	IN
cord-006139-9063uhox	117	14	a	a	DT
cord-006139-9063uhox	117	15	serine	serine	NN
cord-006139-9063uhox	117	16	(	(	-LRB-
cord-006139-9063uhox	117	17	or	or	CC
cord-006139-9063uhox	117	18	threonine	threonine	NN
cord-006139-9063uhox	117	19	)	)	-RRB-
cord-006139-9063uhox	117	20	and	and	CC
cord-006139-9063uhox	117	21	an	an	DT
cord-006139-9063uhox	117	22	aspartate	aspartate	NN
cord-006139-9063uhox	117	23	(	(	-LRB-
cord-006139-9063uhox	117	24	or	or	CC
cord-006139-9063uhox	117	25	glutamate	glutamate	NN
cord-006139-9063uhox	117	26	)	)	-RRB-
cord-006139-9063uhox	117	27	side	side	NN
cord-006139-9063uhox	117	28	chain	chain	NN
cord-006139-9063uhox	117	29	in	in	IN
cord-006139-9063uhox	117	30	PfCRT	PfCRT	NNP
cord-006139-9063uhox	117	31	,	,	,
cord-006139-9063uhox	117	32	which	which	WDT
cord-006139-9063uhox	117	33	are	be	VBP
cord-006139-9063uhox	117	34	separated	separate	VBN
cord-006139-9063uhox	117	35	by	by	IN
cord-006139-9063uhox	117	36	9.2	9.2	CD
cord-006139-9063uhox	117	37	Å.	Å.	NNP
cord-006139-9063uhox	117	38	In	in	IN
cord-006139-9063uhox	117	39	a	a	DT
cord-006139-9063uhox	117	40	second	second	JJ
cord-006139-9063uhox	117	41	study	study	NN
cord-006139-9063uhox	117	42	,	,	,
cord-006139-9063uhox	117	43	which	which	WDT
cord-006139-9063uhox	117	44	has	have	VBZ
cord-006139-9063uhox	117	45	turned	turn	VBN
cord-006139-9063uhox	117	46	out	out	RP
cord-006139-9063uhox	117	47	to	to	TO
cord-006139-9063uhox	117	48	be	be	VB
cord-006139-9063uhox	117	49	more	more	RBR
cord-006139-9063uhox	117	50	influential	influential	JJ
cord-006139-9063uhox	117	51	,	,	,
cord-006139-9063uhox	117	52	a	a	DT
cord-006139-9063uhox	117	53	The	the	DT
cord-006139-9063uhox	117	54	4-aminoquinoline	4-aminoquinoline	CD
cord-006139-9063uhox	117	55	group	group	NN
cord-006139-9063uhox	117	56	is	be	VBZ
cord-006139-9063uhox	117	57	the	the	DT
cord-006139-9063uhox	117	58	smallest	small	JJS
cord-006139-9063uhox	117	59	Fe(III)heme	fe(iii)heme	CD
cord-006139-9063uhox	117	60	-	-	HYPH
cord-006139-9063uhox	117	61	binding	bind	VBG
cord-006139-9063uhox	117	62	fragment	fragment	NN
cord-006139-9063uhox	117	63	[	[	-LRB-
cord-006139-9063uhox	117	64	43	43	CD
cord-006139-9063uhox	117	65	]	]	-RRB-
cord-006139-9063uhox	117	66	.	.	.
cord-006139-9063uhox	118	1	Replacement	replacement	NN
cord-006139-9063uhox	118	2	of	of	IN
cord-006139-9063uhox	118	3	the	the	DT
cord-006139-9063uhox	118	4	quinoline	quinoline	NN
cord-006139-9063uhox	118	5	ring	ring	NN
cord-006139-9063uhox	118	6	N	n	CD
cord-006139-9063uhox	118	7	atom	atom	NN
cord-006139-9063uhox	118	8	with	with	IN
cord-006139-9063uhox	118	9	a	a	DT
cord-006139-9063uhox	118	10	CH	CH	NNP
cord-006139-9063uhox	118	11	group	group	NN
cord-006139-9063uhox	118	12	abolishes	abolish	VBZ
cord-006139-9063uhox	118	13	interaction	interaction	NN
cord-006139-9063uhox	118	14	with	with	IN
cord-006139-9063uhox	118	15	Fe(III)heme	Fe(III)heme	NNP
cord-006139-9063uhox	118	16	,	,	,
cord-006139-9063uhox	118	17	as	as	RB
cord-006139-9063uhox	118	18	well	well	RB
cord-006139-9063uhox	118	19	as	as	IN
cord-006139-9063uhox	118	20	hemozoin	hemozoin	NNP
cord-006139-9063uhox	118	21	inhibitory	inhibitory	JJ
cord-006139-9063uhox	118	22	activity	activity	NN
cord-006139-9063uhox	118	23	and	and	CC
cord-006139-9063uhox	118	24	biological	biological	JJ
cord-006139-9063uhox	118	25	activity	activity	NN
cord-006139-9063uhox	118	26	[	[	-LRB-
cord-006139-9063uhox	118	27	45	45	CD
cord-006139-9063uhox	118	28	]	]	-RRB-
cord-006139-9063uhox	118	29	.	.	.
cord-006139-9063uhox	119	1	Replacement	replacement	NN
cord-006139-9063uhox	119	2	of	of	IN
cord-006139-9063uhox	119	3	the	the	DT
cord-006139-9063uhox	119	4	4-amino	4-amino	CD
cord-006139-9063uhox	119	5	NH	NH	NNP
cord-006139-9063uhox	119	6	group	group	NN
cord-006139-9063uhox	119	7	with	with	IN
cord-006139-9063uhox	119	8	a	a	DT
cord-006139-9063uhox	119	9	CH	CH	NNP
cord-006139-9063uhox	119	10	2	2	CD
cord-006139-9063uhox	119	11	group	group	NN
cord-006139-9063uhox	119	12	weakens	weaken	VBZ
cord-006139-9063uhox	119	13	Fe(III)heme	fe(iii)heme	CD
cord-006139-9063uhox	119	14	binding	bind	VBG
cord-006139-9063uhox	119	15	and	and	CC
cord-006139-9063uhox	119	16	also	also	RB
cord-006139-9063uhox	119	17	abolishes	abolish	VBZ
cord-006139-9063uhox	119	18	hemozoin	hemozoin	NNP
cord-006139-9063uhox	119	19	inhibition	inhibition	NN
cord-006139-9063uhox	119	20	and	and	CC
cord-006139-9063uhox	119	21	biological	biological	JJ
cord-006139-9063uhox	119	22	activity	activity	NN
cord-006139-9063uhox	119	23	[	[	-LRB-
cord-006139-9063uhox	119	24	45	45	CD
cord-006139-9063uhox	119	25	]	]	-RRB-
cord-006139-9063uhox	119	26	.	.	.
cord-006139-9063uhox	120	1	The	the	DT
cord-006139-9063uhox	120	2	Cl	Cl	NNP
cord-006139-9063uhox	120	3	atom	atom	NN
cord-006139-9063uhox	120	4	is	be	VBZ
cord-006139-9063uhox	120	5	necessary	necessary	JJ
cord-006139-9063uhox	120	6	for	for	IN
cord-006139-9063uhox	120	7	the	the	DT
cord-006139-9063uhox	120	8	inhibition	inhibition	NN
cord-006139-9063uhox	120	9	of	of	IN
cord-006139-9063uhox	120	10	hemozoin	hemozoin	NNP
cord-006139-9063uhox	120	11	formation	formation	NN
cord-006139-9063uhox	120	12	.	.	.
cord-006139-9063uhox	121	1	It	-PRON-	PRP
cord-006139-9063uhox	121	2	can	can	MD
cord-006139-9063uhox	121	3	be	be	VB
cord-006139-9063uhox	121	4	replaced	replace	VBN
cord-006139-9063uhox	121	5	with	with	IN
cord-006139-9063uhox	121	6	other	other	JJ
cord-006139-9063uhox	121	7	electron	electron	NN
cord-006139-9063uhox	121	8	-	-	HYPH
cord-006139-9063uhox	121	9	withdrawing	withdraw	VBG
cord-006139-9063uhox	121	10	hydrophobic	hydrophobic	JJ
cord-006139-9063uhox	121	11	groups	group	NNS
cord-006139-9063uhox	121	12	[	[	-LRB-
cord-006139-9063uhox	121	13	44	44	CD
cord-006139-9063uhox	121	14	]	]	-RRB-
cord-006139-9063uhox	121	15	.	.	.
cord-006139-9063uhox	122	1	The	the	DT
cord-006139-9063uhox	122	2	tertiary	tertiary	JJ
cord-006139-9063uhox	122	3	N	n	CD
cord-006139-9063uhox	122	4	atom	atom	NN
cord-006139-9063uhox	122	5	in	in	IN
cord-006139-9063uhox	122	6	the	the	DT
cord-006139-9063uhox	122	7	side	side	NN
cord-006139-9063uhox	122	8	chain	chain	NN
cord-006139-9063uhox	122	9	is	be	VBZ
cord-006139-9063uhox	122	10	important	important	JJ
cord-006139-9063uhox	122	11	for	for	IN
cord-006139-9063uhox	122	12	accumulation	accumulation	NN
cord-006139-9063uhox	122	13	in	in	IN
cord-006139-9063uhox	122	14	the	the	DT
cord-006139-9063uhox	122	15	parasite	parasite	JJ
cord-006139-9063uhox	122	16	digestive	digestive	JJ
cord-006139-9063uhox	122	17	vacuole	vacuole	NN
cord-006139-9063uhox	122	18	through	through	IN
cord-006139-9063uhox	122	19	pH	pH	NNP
cord-006139-9063uhox	122	20	trapping	trapping	NN
cord-006139-9063uhox	122	21	,	,	,
cord-006139-9063uhox	122	22	and	and	CC
cord-006139-9063uhox	122	23	it	-PRON-	PRP
cord-006139-9063uhox	122	24	usually	usually	RB
cord-006139-9063uhox	122	25	improves	improve	VBZ
cord-006139-9063uhox	122	26	activity	activity	NN
cord-006139-9063uhox	122	27	[	[	-LRB-
cord-006139-9063uhox	122	28	43	43	CD
cord-006139-9063uhox	122	29	]	]	-RRB-
cord-006139-9063uhox	122	30	.	.	.
cord-006139-9063uhox	123	1	Analogs	analog	NNS
cord-006139-9063uhox	123	2	are	be	VBP
cord-006139-9063uhox	123	3	known	know	VBN
cord-006139-9063uhox	123	4	in	in	IN
cord-006139-9063uhox	123	5	which	which	WDT
cord-006139-9063uhox	123	6	this	this	DT
cord-006139-9063uhox	123	7	N	n	CD
cord-006139-9063uhox	123	8	atom	atom	NN
cord-006139-9063uhox	123	9	is	be	VBZ
cord-006139-9063uhox	123	10	replaced	replace	VBN
cord-006139-9063uhox	123	11	with	with	IN
cord-006139-9063uhox	123	12	a	a	DT
cord-006139-9063uhox	123	13	CH	CH	NNP
cord-006139-9063uhox	123	14	,	,	,
cord-006139-9063uhox	123	15	retaining	retain	VBG
cord-006139-9063uhox	123	16	biological	biological	JJ
cord-006139-9063uhox	123	17	activity	activity	NN
cord-006139-9063uhox	123	18	[	[	-LRB-
cord-006139-9063uhox	123	19	42	42	CD
cord-006139-9063uhox	123	20	]	]	-RRB-
cord-006139-9063uhox	123	21	.	.	.
cord-006139-9063uhox	124	1	future	future	JJ
cord-006139-9063uhox	124	2	science	science	NNP
cord-006139-9063uhox	124	3	group	group	NN
cord-006139-9063uhox	124	4	series	series	NNP
cord-006139-9063uhox	124	5	of	of	IN
cord-006139-9063uhox	124	6	imipramine	imipramine	NNP
cord-006139-9063uhox	124	7	analogs	analog	NNS
cord-006139-9063uhox	124	8	were	be	VBD
cord-006139-9063uhox	124	9	investigated	investigate	VBN
cord-006139-9063uhox	124	10	,	,	,
cord-006139-9063uhox	124	11	leading	lead	VBG
cord-006139-9063uhox	124	12	to	to	IN
cord-006139-9063uhox	124	13	a	a	DT
cord-006139-9063uhox	124	14	pharmacophore	pharmacophore	NN
cord-006139-9063uhox	124	15	model	model	NN
cord-006139-9063uhox	124	16	consisting	consist	VBG
cord-006139-9063uhox	124	17	of	of	IN
cord-006139-9063uhox	124	18	two	two	CD
cord-006139-9063uhox	124	19	suitably	suitably	RB
cord-006139-9063uhox	124	20	positioned	position	VBD
cord-006139-9063uhox	124	21	aromatic	aromatic	JJ
cord-006139-9063uhox	124	22	groups	group	NNS
cord-006139-9063uhox	124	23	and	and	CC
cord-006139-9063uhox	124	24	a	a	DT
cord-006139-9063uhox	124	25	weak	weak	JJ
cord-006139-9063uhox	124	26	base	base	NN
cord-006139-9063uhox	124	27	amino	amino	NN
cord-006139-9063uhox	124	28	group	group	NN
cord-006139-9063uhox	124	29	(	(	-LRB-
cord-006139-9063uhox	124	30	Figure	Figure	NNP
cord-006139-9063uhox	124	31	7	7	CD
cord-006139-9063uhox	124	32	)	)	-RRB-
cord-006139-9063uhox	125	1	[	[	-LRB-
cord-006139-9063uhox	125	2	74	74	CD
cord-006139-9063uhox	125	3	]	]	-RRB-
cord-006139-9063uhox	125	4	.	.	.
cord-006139-9063uhox	126	1	The	the	DT
cord-006139-9063uhox	126	2	latter	latter	JJ
cord-006139-9063uhox	126	3	study	study	NN
cord-006139-9063uhox	126	4	has	have	VBZ
cord-006139-9063uhox	126	5	underpinned	underpin	VBN
cord-006139-9063uhox	126	6	the	the	DT
cord-006139-9063uhox	126	7	design	design	NN
cord-006139-9063uhox	126	8	of	of	IN
cord-006139-9063uhox	126	9	a	a	DT
cord-006139-9063uhox	126	10	new	new	JJ
cord-006139-9063uhox	126	11	type	type	NN
cord-006139-9063uhox	126	12	of	of	IN
cord-006139-9063uhox	126	13	antimalarial	antimalarial	JJ
cord-006139-9063uhox	126	14	that	that	WDT
cord-006139-9063uhox	126	15	incorporates	incorporate	VBZ
cord-006139-9063uhox	126	16	the	the	DT
cord-006139-9063uhox	126	17	features	feature	NNS
cord-006139-9063uhox	126	18	required	require	VBN
cord-006139-9063uhox	126	19	for	for	IN
cord-006139-9063uhox	126	20	both	both	CC
cord-006139-9063uhox	126	21	an	an	DT
cord-006139-9063uhox	126	22	active	active	JJ
cord-006139-9063uhox	126	23	anti	anti	AFX
cord-006139-9063uhox	126	24	malarial	malarial	JJ
cord-006139-9063uhox	126	25	and	and	CC
cord-006139-9063uhox	126	26	a	a	DT
cord-006139-9063uhox	126	27	resistance	resistance	NN
cord-006139-9063uhox	126	28	-	-	HYPH
cord-006139-9063uhox	126	29	reversing	reverse	VBG
cord-006139-9063uhox	126	30	chemosensitizer	chemosensitizer	NN
cord-006139-9063uhox	126	31	.	.	.
cord-006139-9063uhox	127	1	These	these	DT
cord-006139-9063uhox	127	2	dual	dual	JJ
cord-006139-9063uhox	127	3	-	-	HYPH
cord-006139-9063uhox	127	4	function	function	NN
cord-006139-9063uhox	127	5	compounds	compound	NNS
cord-006139-9063uhox	127	6	,	,	,
cord-006139-9063uhox	127	7	consisting	consist	VBG
cord-006139-9063uhox	127	8	of	of	IN
cord-006139-9063uhox	127	9	so	so	RB
cord-006139-9063uhox	127	10	-	-	HYPH
cord-006139-9063uhox	127	11	called	call	VBN
cord-006139-9063uhox	127	12	'	'	``
cord-006139-9063uhox	127	13	reversed	reverse	VBN
cord-006139-9063uhox	127	14	chloroquines	chloroquine	NNS
cord-006139-9063uhox	127	15	'	'	POS
cord-006139-9063uhox	127	16	and	and	CC
cord-006139-9063uhox	127	17	related	related	JJ
cord-006139-9063uhox	127	18	compounds	compound	NNS
cord-006139-9063uhox	127	19	,	,	,
cord-006139-9063uhox	127	20	are	be	VBP
cord-006139-9063uhox	127	21	the	the	DT
cord-006139-9063uhox	127	22	subject	subject	NN
cord-006139-9063uhox	127	23	of	of	IN
cord-006139-9063uhox	127	24	the	the	DT
cord-006139-9063uhox	127	25	remainder	remainder	NN
cord-006139-9063uhox	127	26	of	of	IN
cord-006139-9063uhox	127	27	this	this	DT
cord-006139-9063uhox	127	28	review	review	NN
cord-006139-9063uhox	127	29	.	.	.
cord-006139-9063uhox	128	1	Dual	dual	JJ
cord-006139-9063uhox	128	2	-	-	HYPH
cord-006139-9063uhox	128	3	function	function	NN
cord-006139-9063uhox	128	4	antimalarials	antimalarial	NNS
cord-006139-9063uhox	128	5	with	with	IN
cord-006139-9063uhox	128	6	both	both	DT
cord-006139-9063uhox	128	7	chloroquine	chloroquine	NN
cord-006139-9063uhox	128	8	-	-	HYPH
cord-006139-9063uhox	128	9	like	like	JJ
cord-006139-9063uhox	128	10	activity	activity	NN
cord-006139-9063uhox	128	11	(	(	-LRB-
cord-006139-9063uhox	128	12	hemozoin	hemozoin	NNP
cord-006139-9063uhox	128	13	inhibition	inhibition	NN
cord-006139-9063uhox	128	14	)	)	-RRB-
cord-006139-9063uhox	128	15	and	and	CC
cord-006139-9063uhox	128	16	resistance	resistance	NN
cord-006139-9063uhox	128	17	-	-	HYPH
cord-006139-9063uhox	128	18	reversing	reverse	VBG
cord-006139-9063uhox	128	19	activity	activity	NN
cord-006139-9063uhox	128	20	form	form	NN
cord-006139-9063uhox	128	21	a	a	DT
cord-006139-9063uhox	128	22	relatively	relatively	RB
cord-006139-9063uhox	128	23	new	new	JJ
cord-006139-9063uhox	128	24	class	class	NN
cord-006139-9063uhox	128	25	of	of	IN
cord-006139-9063uhox	128	26	compounds	compound	NNS
cord-006139-9063uhox	128	27	.	.	.
cord-006139-9063uhox	129	1	The	the	DT
cord-006139-9063uhox	129	2	first	first	JJ
cord-006139-9063uhox	129	3	example	example	NN
cord-006139-9063uhox	129	4	,	,	,
cord-006139-9063uhox	129	5	a	a	DT
cord-006139-9063uhox	129	6	so	so	RB
cord-006139-9063uhox	129	7	-	-	HYPH
cord-006139-9063uhox	129	8	called	call	VBN
cord-006139-9063uhox	129	9	reversed	reversed	JJ
cord-006139-9063uhox	129	10	chloroquine	chloroquine	NN
cord-006139-9063uhox	129	11	(	(	-LRB-
cord-006139-9063uhox	129	12	Compound	compound	NN
cord-006139-9063uhox	129	13	1	1	CD
cord-006139-9063uhox	129	14	)	)	-RRB-
cord-006139-9063uhox	129	15	,	,	,
cord-006139-9063uhox	129	16	was	be	VBD
cord-006139-9063uhox	129	17	reported	report	VBN
cord-006139-9063uhox	129	18	in	in	IN
cord-006139-9063uhox	129	19	2006	2006	CD
cord-006139-9063uhox	129	20	[	[	-LRB-
cord-006139-9063uhox	129	21	75	75	CD
cord-006139-9063uhox	129	22	]	]	-RRB-
cord-006139-9063uhox	129	23	.	.	.
cord-006139-9063uhox	130	1	This	this	DT
cord-006139-9063uhox	130	2	consisted	consist	VBD
cord-006139-9063uhox	130	3	of	of	IN
cord-006139-9063uhox	130	4	a	a	DT
cord-006139-9063uhox	130	5	4-amino-7-chloroquinoline	4-amino-7-chloroquinoline	CD
cord-006139-9063uhox	130	6	moiety	moiety	NN
cord-006139-9063uhox	130	7	linked	link	VBN
cord-006139-9063uhox	130	8	to	to	IN
cord-006139-9063uhox	130	9	the	the	DT
cord-006139-9063uhox	130	10	N	n	CD
cord-006139-9063uhox	130	11	atom	atom	NN
cord-006139-9063uhox	130	12	of	of	IN
cord-006139-9063uhox	130	13	imipramine	imipramine	NN
cord-006139-9063uhox	130	14	via	via	IN
cord-006139-9063uhox	130	15	a	a	DT
cord-006139-9063uhox	130	16	three	three	CD
cord-006139-9063uhox	130	17	-	-	HYPH
cord-006139-9063uhox	130	18	carbon	carbon	NN
cord-006139-9063uhox	130	19	alkyl	alkyl	NN
cord-006139-9063uhox	130	20	linker	linker	NN
cord-006139-9063uhox	130	21	group	group	NN
cord-006139-9063uhox	130	22	(	(	-LRB-
cord-006139-9063uhox	130	23	Figure	figure	NN
cord-006139-9063uhox	130	24	8A	8a	NN
cord-006139-9063uhox	130	25	)	)	-RRB-
cord-006139-9063uhox	130	26	.	.	.
cord-006139-9063uhox	131	1	Compound	compound	NN
cord-006139-9063uhox	131	2	1	1	CD
cord-006139-9063uhox	131	3	was	be	VBD
cord-006139-9063uhox	131	4	shown	show	VBN
cord-006139-9063uhox	131	5	to	to	TO
cord-006139-9063uhox	131	6	be	be	VB
cord-006139-9063uhox	131	7	active	active	JJ
cord-006139-9063uhox	131	8	in	in	IN
cord-006139-9063uhox	131	9	vitro	vitro	FW
cord-006139-9063uhox	131	10	against	against	IN
cord-006139-9063uhox	131	11	both	both	CC
cord-006139-9063uhox	131	12	the	the	DT
cord-006139-9063uhox	131	13	chloroquine	chloroquine	NN
cord-006139-9063uhox	131	14	-	-	HYPH
cord-006139-9063uhox	131	15	sensitive	sensitive	JJ
cord-006139-9063uhox	131	16	D6	d6	NN
cord-006139-9063uhox	131	17	and	and	CC
cord-006139-9063uhox	131	18	chloroquine	chloroquine	NN
cord-006139-9063uhox	131	19	-	-	HYPH
cord-006139-9063uhox	131	20	resistant	resistant	JJ
cord-006139-9063uhox	131	21	Dd2	dd2	NN
cord-006139-9063uhox	131	22	strains	strain	NNS
cord-006139-9063uhox	131	23	of	of	IN
cord-006139-9063uhox	131	24	P.	P.	NNP
cord-006139-9063uhox	131	25	falciparum	falciparum	NN
cord-006139-9063uhox	131	26	.	.	.
cord-006139-9063uhox	132	1	It	-PRON-	PRP
cord-006139-9063uhox	132	2	was	be	VBD
cord-006139-9063uhox	132	3	also	also	RB
cord-006139-9063uhox	132	4	shown	show	VBN
cord-006139-9063uhox	132	5	to	to	TO
cord-006139-9063uhox	132	6	associate	associate	VB
cord-006139-9063uhox	132	7	with	with	IN
cord-006139-9063uhox	132	8	Fe(III)heme	fe(iii)heme	CD
cord-006139-9063uhox	132	9	,	,	,
cord-006139-9063uhox	132	10	both	both	CC
cord-006139-9063uhox	132	11	at	at	IN
cord-006139-9063uhox	132	12	pH	pH	NNP
cord-006139-9063uhox	132	13	5.7	5.7	CD
cord-006139-9063uhox	132	14	and	and	CC
cord-006139-9063uhox	132	15	7	7	CD
cord-006139-9063uhox	132	16	,	,	,
cord-006139-9063uhox	132	17	with	with	IN
cord-006139-9063uhox	132	18	log	log	NNP
cord-006139-9063uhox	132	19	association	association	NN
cord-006139-9063uhox	132	20	constant	constant	NN
cord-006139-9063uhox	132	21	(	(	-LRB-
cord-006139-9063uhox	132	22	logK	logK	NNS
cord-006139-9063uhox	132	23	)	)	-RRB-
cord-006139-9063uhox	132	24	values	value	NNS
cord-006139-9063uhox	132	25	of	of	IN
cord-006139-9063uhox	132	26	5.48	5.48	CD
cord-006139-9063uhox	132	27	(	(	-LRB-
cord-006139-9063uhox	132	28	comparable	comparable	JJ
cord-006139-9063uhox	132	29	to	to	IN
cord-006139-9063uhox	132	30	chloroquine	chloroquine	NN
cord-006139-9063uhox	132	31	,	,	,
cord-006139-9063uhox	132	32	with	with	IN
cord-006139-9063uhox	132	33	values	value	NNS
cord-006139-9063uhox	132	34	of	of	IN
cord-006139-9063uhox	132	35	5.48	5.48	CD
cord-006139-9063uhox	132	36	and	and	CC
cord-006139-9063uhox	132	37	6.00	6.00	CD
cord-006139-9063uhox	132	38	,	,	,
cord-006139-9063uhox	132	39	respectively	respectively	RB
cord-006139-9063uhox	132	40	,	,	,
cord-006139-9063uhox	132	41	at	at	IN
cord-006139-9063uhox	132	42	these	these	DT
cord-006139-9063uhox	132	43	two	two	CD
cord-006139-9063uhox	132	44	pH	pH	NNP
cord-006139-9063uhox	132	45	values	value	NNS
cord-006139-9063uhox	132	46	)	)	-RRB-
cord-006139-9063uhox	132	47	.	.	.
cord-006139-9063uhox	133	1	However	however	RB
cord-006139-9063uhox	133	2	,	,	,
cord-006139-9063uhox	133	3	Compound	Compound	NNP
cord-006139-9063uhox	133	4	1	1	CD
cord-006139-9063uhox	133	5	itself	-PRON-	PRP
cord-006139-9063uhox	133	6	was	be	VBD
cord-006139-9063uhox	133	7	not	not	RB
cord-006139-9063uhox	133	8	considered	consider	VBN
cord-006139-9063uhox	133	9	suitable	suitable	JJ
cord-006139-9063uhox	133	10	for	for	IN
cord-006139-9063uhox	133	11	further	further	JJ
cord-006139-9063uhox	133	12	drug	drug	NN
cord-006139-9063uhox	133	13	development	development	NN
cord-006139-9063uhox	133	14	owing	owe	VBG
cord-006139-9063uhox	133	15	to	to	IN
cord-006139-9063uhox	133	16	its	-PRON-	PRP$
cord-006139-9063uhox	133	17	high	high	JJ
cord-006139-9063uhox	133	18	lipophilicity	lipophilicity	NN
cord-006139-9063uhox	133	19	(	(	-LRB-
cord-006139-9063uhox	133	20	log	log	NN
cord-006139-9063uhox	133	21	distribution	distribution	NN
cord-006139-9063uhox	133	22	constant	constant	NN
cord-006139-9063uhox	133	23	[	[	-LRB-
cord-006139-9063uhox	133	24	clogP	clogP	NNP
cord-006139-9063uhox	133	25	]	]	-RRB-
cord-006139-9063uhox	133	26	=	=	SYM
cord-006139-9063uhox	133	27	8.9	8.9	CD
cord-006139-9063uhox	133	28	)	)	-RRB-
cord-006139-9063uhox	133	29	.	.	.
cord-006139-9063uhox	134	1	In	in	IN
cord-006139-9063uhox	134	2	a	a	DT
cord-006139-9063uhox	134	3	follow	follow	NN
cord-006139-9063uhox	134	4	-	-	HYPH
cord-006139-9063uhox	134	5	up	up	NN
cord-006139-9063uhox	134	6	study	study	NN
cord-006139-9063uhox	134	7	,	,	,
cord-006139-9063uhox	134	8	Peyton	Peyton	NNP
cord-006139-9063uhox	134	9	and	and	CC
cord-006139-9063uhox	134	10	coworkers	coworker	NNS
cord-006139-9063uhox	134	11	investigated	investigate	VBD
cord-006139-9063uhox	134	12	the	the	DT
cord-006139-9063uhox	134	13	effects	effect	NNS
cord-006139-9063uhox	134	14	of	of	IN
cord-006139-9063uhox	134	15	the	the	DT
cord-006139-9063uhox	134	16	linker	linker	NN
cord-006139-9063uhox	134	17	and	and	CC
cord-006139-9063uhox	134	18	head	head	NN
cord-006139-9063uhox	134	19	groups	group	NNS
cord-006139-9063uhox	134	20	in	in	IN
cord-006139-9063uhox	134	21	the	the	DT
cord-006139-9063uhox	134	22	activity	activity	NN
cord-006139-9063uhox	134	23	of	of	IN
cord-006139-9063uhox	134	24	a	a	DT
cord-006139-9063uhox	134	25	range	range	NN
cord-006139-9063uhox	134	26	of	of	IN
cord-006139-9063uhox	134	27	reversed	reversed	JJ
cord-006139-9063uhox	134	28	chloroquines	chloroquine	NNS
cord-006139-9063uhox	134	29	[	[	-LRB-
cord-006139-9063uhox	134	30	76	76	CD
cord-006139-9063uhox	134	31	]	]	-RRB-
cord-006139-9063uhox	134	32	.	.	.
cord-006139-9063uhox	135	1	In	in	IN
cord-006139-9063uhox	135	2	one	one	CD
cord-006139-9063uhox	135	3	study	study	NN
cord-006139-9063uhox	135	4	,	,	,
cord-006139-9063uhox	135	5	the	the	DT
cord-006139-9063uhox	135	6	head	head	NN
cord-006139-9063uhox	135	7	group	group	NN
cord-006139-9063uhox	135	8	was	be	VBD
cord-006139-9063uhox	135	9	altered	alter	VBN
cord-006139-9063uhox	135	10	to	to	IN
cord-006139-9063uhox	135	11	a	a	DT
cord-006139-9063uhox	135	12	diphenylamine	diphenylamine	NN
cord-006139-9063uhox	135	13	or	or	CC
cord-006139-9063uhox	135	14	dibenzylamine	dibenzylamine	NN
cord-006139-9063uhox	135	15	,	,	,
cord-006139-9063uhox	135	16	while	while	IN
cord-006139-9063uhox	135	17	the	the	DT
cord-006139-9063uhox	135	18	aliphatic	aliphatic	JJ
cord-006139-9063uhox	135	19	portion	portion	NN
cord-006139-9063uhox	135	20	of	of	IN
cord-006139-9063uhox	135	21	the	the	DT
cord-006139-9063uhox	135	22	side	side	NN
cord-006139-9063uhox	135	23	chain	chain	NN
cord-006139-9063uhox	135	24	and	and	CC
cord-006139-9063uhox	135	25	linker	linker	NN
cord-006139-9063uhox	135	26	chain	chain	NN
cord-006139-9063uhox	135	27	were	be	VBD
cord-006139-9063uhox	135	28	varied	varied	JJ
cord-006139-9063uhox	135	29	in	in	IN
cord-006139-9063uhox	135	30	length	length	NN
cord-006139-9063uhox	135	31	in	in	IN
cord-006139-9063uhox	135	32	an	an	DT
cord-006139-9063uhox	135	33	effort	effort	NN
cord-006139-9063uhox	135	34	to	to	TO
cord-006139-9063uhox	135	35	reduce	reduce	VB
cord-006139-9063uhox	135	36	lipophilicity	lipophilicity	NN
cord-006139-9063uhox	135	37	[	[	-LRB-
cord-006139-9063uhox	135	38	76	76	CD
cord-006139-9063uhox	135	39	]	]	-RRB-
cord-006139-9063uhox	135	40	.	.	.
cord-006139-9063uhox	136	1	All	all	DT
cord-006139-9063uhox	136	2	of	of	IN
cord-006139-9063uhox	136	3	these	these	DT
cord-006139-9063uhox	136	4	compounds	compound	NNS
cord-006139-9063uhox	136	5	demonstrated	demonstrate	VBD
cord-006139-9063uhox	136	6	strong	strong	JJ
cord-006139-9063uhox	136	7	activity	activity	NN
cord-006139-9063uhox	136	8	against	against	IN
cord-006139-9063uhox	136	9	parasites	parasite	NNS
cord-006139-9063uhox	136	10	cultured	culture	VBN
cord-006139-9063uhox	136	11	in	in	IN
cord-006139-9063uhox	136	12	vitro	vitro	FW
cord-006139-9063uhox	136	13	(	(	-LRB-
cord-006139-9063uhox	136	14	IC	IC	NNP
cord-006139-9063uhox	136	15	50	50	CD
cord-006139-9063uhox	136	16	<	<	XX
cord-006139-9063uhox	136	17	120	120	CD
cord-006139-9063uhox	136	18	nM	nM	NNP
cord-006139-9063uhox	136	19	)	)	-RRB-
cord-006139-9063uhox	136	20	,	,	,
cord-006139-9063uhox	136	21	with	with	IN
cord-006139-9063uhox	136	22	only	only	JJ
cord-006139-9063uhox	136	23	minor	minor	JJ
cord-006139-9063uhox	136	24	differences	difference	NNS
cord-006139-9063uhox	136	25	between	between	IN
cord-006139-9063uhox	136	26	chloroquinesensitive	chloroquinesensitive	JJ
cord-006139-9063uhox	136	27	and	and	CC
cord-006139-9063uhox	136	28	-resistant	-resistant	CD
cord-006139-9063uhox	136	29	D6	d6	NN
cord-006139-9063uhox	136	30	and	and	CC
cord-006139-9063uhox	136	31	Dd2	dd2	NN
cord-006139-9063uhox	136	32	strains	strain	NNS
cord-006139-9063uhox	136	33	.	.	.
cord-006139-9063uhox	137	1	Larger	large	JJR
cord-006139-9063uhox	137	2	differences	difference	NNS
cord-006139-9063uhox	137	3	were	be	VBD
cord-006139-9063uhox	137	4	seen	see	VBN
cord-006139-9063uhox	137	5	in	in	IN
cord-006139-9063uhox	137	6	cytotoxicity	cytotoxicity	NN
cord-006139-9063uhox	137	7	,	,	,
cord-006139-9063uhox	137	8	with	with	IN
cord-006139-9063uhox	137	9	molecules	molecule	NNS
cord-006139-9063uhox	137	10	possessing	possess	VBG
cord-006139-9063uhox	137	11	amide	amide	NN
cord-006139-9063uhox	137	12	or	or	CC
cord-006139-9063uhox	137	13	piperazine	piperazine	NN
cord-006139-9063uhox	137	14	linkers	linker	NNS
cord-006139-9063uhox	137	15	exhibiting	exhibit	VBG
cord-006139-9063uhox	137	16	the	the	DT
cord-006139-9063uhox	137	17	lowest	low	JJS
cord-006139-9063uhox	137	18	toxicity	toxicity	NN
cord-006139-9063uhox	137	19	.	.	.
cord-006139-9063uhox	138	1	Nonetheless	nonetheless	RB
cord-006139-9063uhox	138	2	,	,	,
cord-006139-9063uhox	138	3	all	all	DT
cord-006139-9063uhox	138	4	of	of	IN
cord-006139-9063uhox	138	5	the	the	DT
cord-006139-9063uhox	138	6	compounds	compound	NNS
cord-006139-9063uhox	138	7	tested	test	VBN
cord-006139-9063uhox	138	8	exhibited	exhibit	VBD
cord-006139-9063uhox	138	9	well	well	RB
cord-006139-9063uhox	138	10	over	over	IN
cord-006139-9063uhox	138	11	100-fold	100-fold	CD
cord-006139-9063uhox	138	12	selectivity	selectivity	NN
cord-006139-9063uhox	138	13	against	against	IN
cord-006139-9063uhox	138	14	malaria	malaria	NN
cord-006139-9063uhox	138	15	parasites	parasite	NNS
cord-006139-9063uhox	138	16	.	.	.
cord-006139-9063uhox	139	1	Closer	close	JJR
cord-006139-9063uhox	139	2	scrutiny	scrutiny	NN
cord-006139-9063uhox	139	3	of	of	IN
cord-006139-9063uhox	139	4	the	the	DT
cord-006139-9063uhox	139	5	IC	IC	NNP
cord-006139-9063uhox	139	6	50	50	CD
cord-006139-9063uhox	139	7	values	value	NNS
cord-006139-9063uhox	139	8	showed	show	VBD
cord-006139-9063uhox	139	9	that	that	IN
cord-006139-9063uhox	139	10	a	a	DT
cord-006139-9063uhox	139	11	dibenzylamine	dibenzylamine	JJ
cord-006139-9063uhox	139	12	head	head	NN
cord-006139-9063uhox	139	13	group	group	NN
cord-006139-9063uhox	139	14	usually	usually	RB
cord-006139-9063uhox	139	15	gave	give	VBD
cord-006139-9063uhox	139	16	rise	rise	NN
cord-006139-9063uhox	139	17	to	to	IN
cord-006139-9063uhox	139	18	a	a	DT
cord-006139-9063uhox	139	19	more	more	RBR
cord-006139-9063uhox	139	20	active	active	JJ
cord-006139-9063uhox	139	21	compound	compound	NN
cord-006139-9063uhox	139	22	than	than	IN
cord-006139-9063uhox	139	23	the	the	DT
cord-006139-9063uhox	139	24	corresponding	corresponding	JJ
cord-006139-9063uhox	139	25	compound	compound	NN
cord-006139-9063uhox	139	26	with	with	IN
cord-006139-9063uhox	139	27	a	a	DT
cord-006139-9063uhox	139	28	diphenylamine	diphenylamine	JJ
cord-006139-9063uhox	139	29	head	head	NN
cord-006139-9063uhox	139	30	group	group	NN
cord-006139-9063uhox	139	31	,	,	,
cord-006139-9063uhox	139	32	and	and	CC
cord-006139-9063uhox	139	33	that	that	DT
cord-006139-9063uhox	139	34	replacement	replacement	NN
cord-006139-9063uhox	139	35	of	of	IN
cord-006139-9063uhox	139	36	the	the	DT
cord-006139-9063uhox	139	37	linear	linear	JJ
cord-006139-9063uhox	139	38	diamine	diamine	NN
cord-006139-9063uhox	139	39	linker	linker	NN
cord-006139-9063uhox	139	40	with	with	IN
cord-006139-9063uhox	139	41	a	a	DT
cord-006139-9063uhox	139	42	piperazine	piperazine	NN
cord-006139-9063uhox	139	43	group	group	NN
cord-006139-9063uhox	139	44	also	also	RB
cord-006139-9063uhox	139	45	generally	generally	RB
cord-006139-9063uhox	139	46	decreased	decrease	VBD
cord-006139-9063uhox	139	47	activity	activity	NN
cord-006139-9063uhox	139	48	.	.	.
cord-006139-9063uhox	140	1	On	on	IN
cord-006139-9063uhox	140	2	the	the	DT
cord-006139-9063uhox	140	3	other	other	JJ
cord-006139-9063uhox	140	4	hand	hand	NN
cord-006139-9063uhox	140	5	,	,	,
cord-006139-9063uhox	140	6	introduction	introduction	NN
cord-006139-9063uhox	140	7	of	of	IN
cord-006139-9063uhox	140	8	an	an	DT
cord-006139-9063uhox	140	9	amide	amide	NN
cord-006139-9063uhox	140	10	head	head	NN
cord-006139-9063uhox	140	11	group	group	NN
cord-006139-9063uhox	140	12	was	be	VBD
cord-006139-9063uhox	140	13	tolerated	tolerate	VBN
cord-006139-9063uhox	140	14	and	and	CC
cord-006139-9063uhox	140	15	permitted	permit	VBD
cord-006139-9063uhox	140	16	a	a	DT
cord-006139-9063uhox	140	17	decrease	decrease	NN
cord-006139-9063uhox	140	18	in	in	IN
cord-006139-9063uhox	140	19	clogP	clogP	NNP
cord-006139-9063uhox	140	20	to	to	IN
cord-006139-9063uhox	140	21	values	value	NNS
cord-006139-9063uhox	140	22	comparable	comparable	JJ
cord-006139-9063uhox	140	23	to	to	IN
cord-006139-9063uhox	140	24	chloroquine	chloroquine	NN
cord-006139-9063uhox	140	25	.	.	.
cord-006139-9063uhox	141	1	In	in	IN
cord-006139-9063uhox	141	2	a	a	DT
cord-006139-9063uhox	141	3	subsequent	subsequent	JJ
cord-006139-9063uhox	141	4	and	and	CC
cord-006139-9063uhox	141	5	more	more	RBR
cord-006139-9063uhox	141	6	comprehensive	comprehensive	JJ
cord-006139-9063uhox	141	7	study	study	NN
cord-006139-9063uhox	141	8	,	,	,
cord-006139-9063uhox	141	9	this	this	DT
cord-006139-9063uhox	141	10	group	group	NN
cord-006139-9063uhox	141	11	made	make	VBD
cord-006139-9063uhox	141	12	further	further	JJ
cord-006139-9063uhox	141	13	variations	variation	NNS
cord-006139-9063uhox	141	14	to	to	IN
cord-006139-9063uhox	141	15	this	this	DT
cord-006139-9063uhox	141	16	chemotype	chemotype	NN
cord-006139-9063uhox	141	17	,	,	,
cord-006139-9063uhox	141	18	replacing	replace	VBG
cord-006139-9063uhox	141	19	the	the	DT
cord-006139-9063uhox	141	20	diphenyl	diphenyl	NNP
cord-006139-9063uhox	141	21	-	-	:
cord-006139-9063uhox	141	22	or	or	CC
cord-006139-9063uhox	141	23	dibenzylamine	dibenzylamine	JJ
cord-006139-9063uhox	141	24	head	head	NN
cord-006139-9063uhox	141	25	group	group	NN
cord-006139-9063uhox	141	26	with	with	IN
cord-006139-9063uhox	141	27	others	other	NNS
cord-006139-9063uhox	141	28	such	such	JJ
cord-006139-9063uhox	141	29	as	as	IN
cord-006139-9063uhox	141	30	benzhydryl	benzhydryl	NNP
cord-006139-9063uhox	141	31	,	,	,
cord-006139-9063uhox	141	32	The	the	DT
cord-006139-9063uhox	141	33	reliability	reliability	NN
cord-006139-9063uhox	141	34	of	of	IN
cord-006139-9063uhox	141	35	this	this	DT
cord-006139-9063uhox	141	36	structural	structural	JJ
cord-006139-9063uhox	141	37	model	model	NN
cord-006139-9063uhox	141	38	remains	remain	VBZ
cord-006139-9063uhox	141	39	untested	untested	JJ
cord-006139-9063uhox	141	40	.	.	.
cord-006139-9063uhox	142	1	Side	side	NN
cord-006139-9063uhox	142	2	chains	chain	NNS
cord-006139-9063uhox	142	3	of	of	IN
cord-006139-9063uhox	142	4	residues	residue	NNS
cord-006139-9063uhox	142	5	at	at	IN
cord-006139-9063uhox	142	6	sites	site	NNS
cord-006139-9063uhox	142	7	of	of	IN
cord-006139-9063uhox	142	8	mutations	mutation	NNS
cord-006139-9063uhox	142	9	implicated	implicate	VBN
cord-006139-9063uhox	142	10	in	in	IN
cord-006139-9063uhox	142	11	chloroquine	chloroquine	NN
cord-006139-9063uhox	142	12	resistance	resistance	NN
cord-006139-9063uhox	142	13	are	be	VBP
cord-006139-9063uhox	142	14	shown	show	VBN
cord-006139-9063uhox	142	15	as	as	IN
cord-006139-9063uhox	142	16	space	space	NN
cord-006139-9063uhox	142	17	-	-	HYPH
cord-006139-9063uhox	142	18	filling	fill	VBG
cord-006139-9063uhox	142	19	spheres	sphere	NNS
cord-006139-9063uhox	142	20	,	,	,
cord-006139-9063uhox	142	21	and	and	CC
cord-006139-9063uhox	142	22	K76	K76	NNP
cord-006139-9063uhox	142	23	is	be	VBZ
cord-006139-9063uhox	142	24	marked	mark	VBN
cord-006139-9063uhox	142	25	by	by	IN
cord-006139-9063uhox	142	26	an	an	DT
cord-006139-9063uhox	142	27	arrow	arrow	NN
cord-006139-9063uhox	142	28	.	.	.
cord-006139-9063uhox	143	1	The	the	DT
cord-006139-9063uhox	143	2	structural	structural	JJ
cord-006139-9063uhox	143	3	model	model	NN
cord-006139-9063uhox	143	4	of	of	IN
cord-006139-9063uhox	143	5	the	the	DT
cord-006139-9063uhox	143	6	protein	protein	NN
cord-006139-9063uhox	143	7	shown	show	VBN
cord-006139-9063uhox	143	8	here	here	RB
cord-006139-9063uhox	143	9	was	be	VBD
cord-006139-9063uhox	143	10	created	create	VBN
cord-006139-9063uhox	143	11	using	use	VBG
cord-006139-9063uhox	143	12	data	datum	NNS
cord-006139-9063uhox	143	13	taken	take	VBN
cord-006139-9063uhox	143	14	from	from	IN
cord-006139-9063uhox	143	15	[	[	-LRB-
cord-006139-9063uhox	143	16	95	95	CD
cord-006139-9063uhox	143	17	]	]	-RRB-
cord-006139-9063uhox	143	18	.	.	.
cord-006139-9063uhox	144	1	future	future	JJ
cord-006139-9063uhox	144	2	science	science	NN
cord-006139-9063uhox	144	3	group	group	NNP
cord-006139-9063uhox	144	4	adamantyl	adamantyl	NNP
cord-006139-9063uhox	144	5	,	,	,
cord-006139-9063uhox	144	6	triphenylmethyl	triphenylmethyl	NN
cord-006139-9063uhox	144	7	and	and	CC
cord-006139-9063uhox	144	8	pyridine-2-yl	pyridine-2-yl	LS
cord-006139-9063uhox	144	9	methyl	methyl	NN
cord-006139-9063uhox	144	10	groups	group	NNS
cord-006139-9063uhox	144	11	[	[	-LRB-
cord-006139-9063uhox	144	12	77	77	CD
cord-006139-9063uhox	144	13	]	]	-RRB-
cord-006139-9063uhox	144	14	.	.	.
cord-006139-9063uhox	145	1	Benzhydryl	Benzhydryl	NNP
cord-006139-9063uhox	145	2	head	head	NN
cord-006139-9063uhox	145	3	groups	group	NNS
cord-006139-9063uhox	145	4	with	with	IN
cord-006139-9063uhox	145	5	substituents	substituent	NNS
cord-006139-9063uhox	145	6	were	be	VBD
cord-006139-9063uhox	145	7	also	also	RB
cord-006139-9063uhox	145	8	investigated	investigate	VBN
cord-006139-9063uhox	145	9	.	.	.
cord-006139-9063uhox	146	1	Interestingly	interestingly	RB
cord-006139-9063uhox	146	2	,	,	,
cord-006139-9063uhox	146	3	the	the	DT
cord-006139-9063uhox	146	4	variations	variation	NNS
cord-006139-9063uhox	146	5	in	in	IN
cord-006139-9063uhox	146	6	head	head	NN
cord-006139-9063uhox	146	7	group	group	NN
cord-006139-9063uhox	146	8	had	have	VBD
cord-006139-9063uhox	146	9	a	a	DT
cord-006139-9063uhox	146	10	relatively	relatively	RB
cord-006139-9063uhox	146	11	small	small	JJ
cord-006139-9063uhox	146	12	influence	influence	NN
cord-006139-9063uhox	146	13	on	on	IN
cord-006139-9063uhox	146	14	activity	activity	NN
cord-006139-9063uhox	146	15	against	against	IN
cord-006139-9063uhox	146	16	either	either	CC
cord-006139-9063uhox	146	17	the	the	DT
cord-006139-9063uhox	146	18	D6	D6	NNP
cord-006139-9063uhox	146	19	chloroquine	chloroquine	NN
cord-006139-9063uhox	146	20	-	-	HYPH
cord-006139-9063uhox	146	21	sensitive	sensitive	JJ
cord-006139-9063uhox	146	22	or	or	CC
cord-006139-9063uhox	146	23	Dd2	dd2	JJ
cord-006139-9063uhox	146	24	chloroquineresistant	chloroquineresistant	NN
cord-006139-9063uhox	146	25	strains	strain	NNS
cord-006139-9063uhox	146	26	of	of	IN
cord-006139-9063uhox	146	27	the	the	DT
cord-006139-9063uhox	146	28	parasite	parasite	NN
cord-006139-9063uhox	146	29	,	,	,
cord-006139-9063uhox	146	30	but	but	CC
cord-006139-9063uhox	146	31	considerably	considerably	RB
cord-006139-9063uhox	146	32	more	more	JJR
cord-006139-9063uhox	146	33	variation	variation	NN
cord-006139-9063uhox	146	34	was	be	VBD
cord-006139-9063uhox	146	35	observed	observe	VBN
cord-006139-9063uhox	146	36	in	in	IN
cord-006139-9063uhox	146	37	activity	activity	NN
cord-006139-9063uhox	146	38	against	against	IN
cord-006139-9063uhox	146	39	the	the	DT
cord-006139-9063uhox	146	40	7G8	7g8	CD
cord-006139-9063uhox	146	41	chloroquine	chloroquine	NN
cord-006139-9063uhox	146	42	-	-	HYPH
cord-006139-9063uhox	146	43	resistant	resistant	JJ
cord-006139-9063uhox	146	44	strain	strain	NN
cord-006139-9063uhox	146	45	.	.	.
cord-006139-9063uhox	147	1	Indeed	indeed	RB
cord-006139-9063uhox	147	2	,	,	,
cord-006139-9063uhox	147	3	in	in	IN
cord-006139-9063uhox	147	4	many	many	JJ
cord-006139-9063uhox	147	5	of	of	IN
cord-006139-9063uhox	147	6	the	the	DT
cord-006139-9063uhox	147	7	derivatives	derivative	NNS
cord-006139-9063uhox	147	8	,	,	,
cord-006139-9063uhox	147	9	activity	activity	NN
cord-006139-9063uhox	147	10	against	against	IN
cord-006139-9063uhox	147	11	the	the	DT
cord-006139-9063uhox	147	12	7G8	7g8	CD
cord-006139-9063uhox	147	13	strain	strain	NN
cord-006139-9063uhox	147	14	was	be	VBD
cord-006139-9063uhox	147	15	four	four	CD
cord-006139-9063uhox	147	16	-	-	HYPH
cord-006139-9063uhox	147	17	to	to	TO
cord-006139-9063uhox	147	18	five	five	CD
cord-006139-9063uhox	147	19	-	-	RB
cord-006139-9063uhox	147	20	fold	fold	VB
cord-006139-9063uhox	147	21	weaker	weak	JJR
cord-006139-9063uhox	147	22	than	than	IN
cord-006139-9063uhox	147	23	against	against	IN
cord-006139-9063uhox	147	24	the	the	DT
cord-006139-9063uhox	147	25	D6	d6	NN
cord-006139-9063uhox	147	26	or	or	CC
cord-006139-9063uhox	147	27	Dd2	dd2	NN
cord-006139-9063uhox	147	28	strains	strain	NNS
cord-006139-9063uhox	147	29	.	.	.
cord-006139-9063uhox	148	1	This	this	DT
cord-006139-9063uhox	148	2	is	be	VBZ
cord-006139-9063uhox	148	3	notable	notable	JJ
cord-006139-9063uhox	148	4	in	in	IN
cord-006139-9063uhox	148	5	view	view	NN
cord-006139-9063uhox	148	6	of	of	IN
cord-006139-9063uhox	148	7	the	the	DT
cord-006139-9063uhox	148	8	fact	fact	NN
cord-006139-9063uhox	148	9	that	that	IN
cord-006139-9063uhox	148	10	the	the	DT
cord-006139-9063uhox	148	11	7G8	7g8	CD
cord-006139-9063uhox	148	12	strain	strain	NN
cord-006139-9063uhox	148	13	,	,	,
cord-006139-9063uhox	148	14	which	which	WDT
cord-006139-9063uhox	148	15	originates	originate	VBZ
cord-006139-9063uhox	148	16	from	from	IN
cord-006139-9063uhox	148	17	South	South	NNP
cord-006139-9063uhox	148	18	America	America	NNP
cord-006139-9063uhox	148	19	,	,	,
cord-006139-9063uhox	148	20	differs	differ	VBZ
cord-006139-9063uhox	148	21	from	from	IN
cord-006139-9063uhox	148	22	the	the	DT
cord-006139-9063uhox	148	23	Old	Old	NNP
cord-006139-9063uhox	148	24	World	World	NNP
cord-006139-9063uhox	148	25	D6	d6	NN
cord-006139-9063uhox	148	26	and	and	CC
cord-006139-9063uhox	148	27	Dd2	dd2	NN
cord-006139-9063uhox	148	28	strains	strain	NNS
cord-006139-9063uhox	148	29	in	in	IN
cord-006139-9063uhox	148	30	as	as	RB
cord-006139-9063uhox	148	31	much	much	JJ
cord-006139-9063uhox	148	32	as	as	IN
cord-006139-9063uhox	148	33	verapamil	verapamil	NN
cord-006139-9063uhox	148	34	has	have	VBZ
cord-006139-9063uhox	148	35	only	only	RB
cord-006139-9063uhox	148	36	weak	weak	JJ
cord-006139-9063uhox	148	37	chemosensitizing	chemosensitizing	NN
cord-006139-9063uhox	148	38	activity	activity	NN
cord-006139-9063uhox	148	39	on	on	IN
cord-006139-9063uhox	148	40	it	-PRON-	PRP
cord-006139-9063uhox	148	41	.	.	.
cord-006139-9063uhox	149	1	This	this	DT
cord-006139-9063uhox	149	2	perhaps	perhaps	RB
cord-006139-9063uhox	149	3	supports	support	VBZ
cord-006139-9063uhox	149	4	the	the	DT
cord-006139-9063uhox	149	5	proposal	proposal	NN
cord-006139-9063uhox	149	6	that	that	IN
cord-006139-9063uhox	149	7	the	the	DT
cord-006139-9063uhox	149	8	activities	activity	NNS
cord-006139-9063uhox	149	9	of	of	IN
cord-006139-9063uhox	149	10	these	these	DT
cord-006139-9063uhox	149	11	compounds	compound	NNS
cord-006139-9063uhox	149	12	relates	relate	VBZ
cord-006139-9063uhox	149	13	to	to	IN
cord-006139-9063uhox	149	14	the	the	DT
cord-006139-9063uhox	149	15	presence	presence	NN
cord-006139-9063uhox	149	16	of	of	IN
cord-006139-9063uhox	149	17	a	a	DT
cord-006139-9063uhox	149	18	resistance	resistance	NN
cord-006139-9063uhox	149	19	-	-	HYPH
cord-006139-9063uhox	149	20	reversing	reverse	VBG
cord-006139-9063uhox	149	21	pharmacophore	pharmacophore	NN
cord-006139-9063uhox	149	22	.	.	.
cord-006139-9063uhox	150	1	Of	of	IN
cord-006139-9063uhox	150	2	particular	particular	JJ
cord-006139-9063uhox	150	3	note	note	NN
cord-006139-9063uhox	150	4	,	,	,
cord-006139-9063uhox	150	5	however	however	RB
cord-006139-9063uhox	150	6	,	,	,
cord-006139-9063uhox	150	7	is	be	VBZ
cord-006139-9063uhox	150	8	a	a	DT
cord-006139-9063uhox	150	9	derivative	derivative	JJ
cord-006139-9063uhox	150	10	,	,	,
cord-006139-9063uhox	150	11	Compound	Compound	NNP
cord-006139-9063uhox	150	12	2	2	CD
cord-006139-9063uhox	150	13	,	,	,
cord-006139-9063uhox	150	14	in	in	IN
cord-006139-9063uhox	150	15	which	which	WDT
cord-006139-9063uhox	150	16	the	the	DT
cord-006139-9063uhox	150	17	phenyl	phenyl	NNP
cord-006139-9063uhox	150	18	rings	ring	VBZ
cord-006139-9063uhox	150	19	in	in	IN
cord-006139-9063uhox	150	20	the	the	DT
cord-006139-9063uhox	150	21	head	head	NN
cord-006139-9063uhox	150	22	group	group	NN
cord-006139-9063uhox	150	23	were	be	VBD
cord-006139-9063uhox	150	24	replaced	replace	VBN
cord-006139-9063uhox	150	25	with	with	IN
cord-006139-9063uhox	150	26	ortho	ortho	NNP
cord-006139-9063uhox	150	27	-	-	HYPH
cord-006139-9063uhox	150	28	pyridyl	pyridyl	NNP
cord-006139-9063uhox	150	29	groups	group	NNS
cord-006139-9063uhox	150	30	(	(	-LRB-
cord-006139-9063uhox	150	31	Figure	figure	NN
cord-006139-9063uhox	150	32	8B	8b	NN
cord-006139-9063uhox	150	33	)	)	-RRB-
cord-006139-9063uhox	150	34	[	[	-LRB-
cord-006139-9063uhox	150	35	77	77	CD
cord-006139-9063uhox	150	36	]	]	-RRB-
cord-006139-9063uhox	150	37	.	.	.
cord-006139-9063uhox	151	1	This	this	DT
cord-006139-9063uhox	151	2	compound	compound	NN
cord-006139-9063uhox	151	3	was	be	VBD
cord-006139-9063uhox	151	4	equipotent	equipotent	JJ
cord-006139-9063uhox	151	5	against	against	IN
cord-006139-9063uhox	151	6	all	all	DT
cord-006139-9063uhox	151	7	three	three	CD
cord-006139-9063uhox	151	8	of	of	IN
cord-006139-9063uhox	151	9	the	the	DT
cord-006139-9063uhox	151	10	tested	test	VBN
cord-006139-9063uhox	151	11	strains	strain	NNS
cord-006139-9063uhox	151	12	and	and	CC
cord-006139-9063uhox	151	13	is	be	VBZ
cord-006139-9063uhox	151	14	substantially	substantially	RB
cord-006139-9063uhox	151	15	less	less	RBR
cord-006139-9063uhox	151	16	lipophilic	lipophilic	JJ
cord-006139-9063uhox	151	17	(	(	-LRB-
cord-006139-9063uhox	151	18	clogP	clogP	NNP
cord-006139-9063uhox	151	19	=	=	SYM
cord-006139-9063uhox	151	20	3.6	3.6	CD
cord-006139-9063uhox	151	21	)	)	-RRB-
cord-006139-9063uhox	151	22	than	than	IN
cord-006139-9063uhox	151	23	the	the	DT
cord-006139-9063uhox	151	24	other	other	JJ
cord-006139-9063uhox	151	25	compounds	compound	NNS
cord-006139-9063uhox	151	26	,	,	,
cord-006139-9063uhox	151	27	a	a	DT
cord-006139-9063uhox	151	28	factor	factor	NN
cord-006139-9063uhox	151	29	that	that	WDT
cord-006139-9063uhox	151	30	is	be	VBZ
cord-006139-9063uhox	151	31	important	important	JJ
cord-006139-9063uhox	151	32	in	in	IN
cord-006139-9063uhox	151	33	improving	improve	VBG
cord-006139-9063uhox	151	34	solubility	solubility	NN
cord-006139-9063uhox	151	35	and	and	CC
cord-006139-9063uhox	151	36	potentially	potentially	RB
cord-006139-9063uhox	151	37	lowering	lower	VBG
cord-006139-9063uhox	151	38	systemic	systemic	JJ
cord-006139-9063uhox	151	39	toxicity	toxicity	NN
cord-006139-9063uhox	151	40	.	.	.
cord-006139-9063uhox	152	1	This	this	DT
cord-006139-9063uhox	152	2	compound	compound	NN
cord-006139-9063uhox	152	3	represents	represent	VBZ
cord-006139-9063uhox	152	4	a	a	DT
cord-006139-9063uhox	152	5	potential	potential	JJ
cord-006139-9063uhox	152	6	lead	lead	NN
cord-006139-9063uhox	152	7	compound	compound	NN
cord-006139-9063uhox	152	8	for	for	IN
cord-006139-9063uhox	152	9	further	further	JJ
cord-006139-9063uhox	152	10	development	development	NN
cord-006139-9063uhox	152	11	.	.	.
cord-006139-9063uhox	153	1	Indeed	indeed	RB
cord-006139-9063uhox	153	2	,	,	,
cord-006139-9063uhox	153	3	it	-PRON-	PRP
cord-006139-9063uhox	153	4	was	be	VBD
cord-006139-9063uhox	153	5	found	find	VBN
cord-006139-9063uhox	153	6	to	to	TO
cord-006139-9063uhox	153	7	possess	possess	VB
cord-006139-9063uhox	153	8	good	good	JJ
cord-006139-9063uhox	153	9	oral	oral	JJ
cord-006139-9063uhox	153	10	activity	activity	NN
cord-006139-9063uhox	153	11	in	in	IN
cord-006139-9063uhox	153	12	the	the	DT
cord-006139-9063uhox	153	13	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	153	14	berghei	berghei	NN
cord-006139-9063uhox	153	15	mouse	mouse	NN
cord-006139-9063uhox	153	16	model	model	NN
cord-006139-9063uhox	153	17	of	of	IN
cord-006139-9063uhox	153	18	malaria	malaria	NN
cord-006139-9063uhox	153	19	,	,	,
cord-006139-9063uhox	153	20	with	with	IN
cord-006139-9063uhox	153	21	four	four	CD
cord-006139-9063uhox	153	22	doses	dose	NNS
cord-006139-9063uhox	153	23	at	at	IN
cord-006139-9063uhox	153	24	30	30	CD
cord-006139-9063uhox	153	25	mg	mg	NN
cord-006139-9063uhox	153	26	/	/	SYM
cord-006139-9063uhox	153	27	kg	kg	NN
cord-006139-9063uhox	153	28	reducing	reduce	VBG
cord-006139-9063uhox	153	29	parasitemia	parasitemia	NNP
cord-006139-9063uhox	153	30	by	by	IN
cord-006139-9063uhox	153	31	more	more	JJR
cord-006139-9063uhox	153	32	than	than	IN
cord-006139-9063uhox	153	33	99	99	CD
cord-006139-9063uhox	153	34	%	%	NN
cord-006139-9063uhox	153	35	and	and	CC
cord-006139-9063uhox	153	36	curing	cure	VBG
cord-006139-9063uhox	153	37	two	two	CD
cord-006139-9063uhox	153	38	out	out	IN
cord-006139-9063uhox	153	39	of	of	IN
cord-006139-9063uhox	153	40	three	three	CD
cord-006139-9063uhox	153	41	treated	treat	VBN
cord-006139-9063uhox	153	42	mice	mouse	NNS
cord-006139-9063uhox	153	43	.	.	.
cord-006139-9063uhox	154	1	A	a	DT
cord-006139-9063uhox	154	2	selection	selection	NN
cord-006139-9063uhox	154	3	of	of	IN
cord-006139-9063uhox	154	4	these	these	DT
cord-006139-9063uhox	154	5	reversed	reverse	VBN
cord-006139-9063uhox	154	6	chloroquines	chloroquine	NNS
cord-006139-9063uhox	154	7	were	be	VBD
cord-006139-9063uhox	154	8	investigated	investigate	VBN
cord-006139-9063uhox	154	9	for	for	IN
cord-006139-9063uhox	154	10	their	-PRON-	PRP$
cord-006139-9063uhox	154	11	Fe(III)heme	Fe(III)heme	NNP
cord-006139-9063uhox	154	12	binding	binding	NN
cord-006139-9063uhox	154	13	and	and	CC
cord-006139-9063uhox	154	14	b	b	NN
cord-006139-9063uhox	154	15	-	-	HYPH
cord-006139-9063uhox	154	16	hematin	hematin	NN
cord-006139-9063uhox	154	17	inhibiting	inhibit	VBG
cord-006139-9063uhox	154	18	activities	activity	NNS
cord-006139-9063uhox	154	19	.	.	.
cord-006139-9063uhox	155	1	They	-PRON-	PRP
cord-006139-9063uhox	155	2	were	be	VBD
cord-006139-9063uhox	155	3	found	find	VBN
cord-006139-9063uhox	155	4	to	to	TO
cord-006139-9063uhox	155	5	exhibit	exhibit	VB
cord-006139-9063uhox	155	6	dissociation	dissociation	NN
cord-006139-9063uhox	155	7	constant	constant	JJ
cord-006139-9063uhox	155	8	values	value	NNS
cord-006139-9063uhox	155	9	(	(	-LRB-
cord-006139-9063uhox	155	10	K	k	NN
cord-006139-9063uhox	155	11	d	d	NN
cord-006139-9063uhox	155	12	)	)	-RRB-
cord-006139-9063uhox	155	13	ranging	range	VBG
cord-006139-9063uhox	155	14	from	from	IN
cord-006139-9063uhox	155	15	8.6	8.6	CD
cord-006139-9063uhox	155	16	to	to	IN
cord-006139-9063uhox	155	17	1.0	1.0	CD
cord-006139-9063uhox	155	18	µM	µm	JJ
cord-006139-9063uhox	155	19	(	(	-LRB-
cord-006139-9063uhox	155	20	logK	logK	NNS
cord-006139-9063uhox	155	21	=	=	NFP
cord-006139-9063uhox	156	1	5.1	5.1	CD
cord-006139-9063uhox	156	2	-	-	SYM
cord-006139-9063uhox	156	3	6.0	6.0	CD
cord-006139-9063uhox	156	4	)	)	-RRB-
cord-006139-9063uhox	156	5	,	,	,
cord-006139-9063uhox	156	6	similar	similar	JJ
cord-006139-9063uhox	156	7	to	to	IN
cord-006139-9063uhox	156	8	that	that	DT
cord-006139-9063uhox	156	9	of	of	IN
cord-006139-9063uhox	156	10	chloroquine	chloroquine	NN
cord-006139-9063uhox	156	11	with	with	IN
cord-006139-9063uhox	156	12	a	a	DT
cord-006139-9063uhox	156	13	K	K	NNP
cord-006139-9063uhox	156	14	d	d	NN
cord-006139-9063uhox	156	15	of	of	IN
cord-006139-9063uhox	156	16	4.0	4.0	CD
cord-006139-9063uhox	156	17	µM	µm	XX
cord-006139-9063uhox	157	1	(	(	-LRB-
cord-006139-9063uhox	157	2	logK	logK	NNP
cord-006139-9063uhox	157	3	=	=	SYM
cord-006139-9063uhox	157	4	5.4	5.4	CD
cord-006139-9063uhox	157	5	)	)	-RRB-
cord-006139-9063uhox	157	6	.	.	.
cord-006139-9063uhox	158	1	The	the	DT
cord-006139-9063uhox	158	2	IC	IC	NNP
cord-006139-9063uhox	158	3	50	50	CD
cord-006139-9063uhox	158	4	values	value	NNS
cord-006139-9063uhox	158	5	for	for	IN
cord-006139-9063uhox	158	6	b	b	NN
cord-006139-9063uhox	158	7	-	-	HYPH
cord-006139-9063uhox	158	8	hematin	hematin	NN
cord-006139-9063uhox	158	9	inhibition	inhibition	NN
cord-006139-9063uhox	158	10	(	(	-LRB-
cord-006139-9063uhox	158	11	1.6	1.6	CD
cord-006139-9063uhox	158	12	-	-	SYM
cord-006139-9063uhox	158	13	14	14	CD
cord-006139-9063uhox	158	14	µM	µm	CD
cord-006139-9063uhox	158	15	)	)	-RRB-
cord-006139-9063uhox	158	16	were	be	VBD
cord-006139-9063uhox	158	17	lower	low	JJR
cord-006139-9063uhox	158	18	than	than	IN
cord-006139-9063uhox	158	19	that	that	DT
cord-006139-9063uhox	158	20	of	of	IN
cord-006139-9063uhox	158	21	chloroquine	chloroquine	NN
cord-006139-9063uhox	158	22	(	(	-LRB-
cord-006139-9063uhox	158	23	24	24	CD
cord-006139-9063uhox	158	24	µM	µM	NNP
cord-006139-9063uhox	158	25	)	)	-RRB-
cord-006139-9063uhox	158	26	,	,	,
cord-006139-9063uhox	158	27	and	and	CC
cord-006139-9063uhox	158	28	a	a	DT
cord-006139-9063uhox	158	29	significant	significant	JJ
cord-006139-9063uhox	158	30	(	(	-LRB-
cord-006139-9063uhox	158	31	R	r	NN
cord-006139-9063uhox	158	32	2	2	CD
cord-006139-9063uhox	158	33	=	=	SYM
cord-006139-9063uhox	158	34	0.66	0.66	CD
cord-006139-9063uhox	158	35	)	)	-RRB-
cord-006139-9063uhox	158	36	correlation	correlation	NN
cord-006139-9063uhox	158	37	between	between	IN
cord-006139-9063uhox	158	38	b	b	NN
cord-006139-9063uhox	158	39	-	-	HYPH
cord-006139-9063uhox	158	40	hematin	hematin	NN
cord-006139-9063uhox	158	41	inhibitory	inhibitory	JJ
cord-006139-9063uhox	158	42	IC	IC	NNP
cord-006139-9063uhox	159	1	50	50	CD
cord-006139-9063uhox	159	2	and	and	CC
cord-006139-9063uhox	159	3	in	in	IN
cord-006139-9063uhox	159	4	vitro	vitro	FW
cord-006139-9063uhox	159	5	antimalarial	antimalarial	JJ
cord-006139-9063uhox	159	6	activity	activity	NN
cord-006139-9063uhox	159	7	against	against	IN
cord-006139-9063uhox	159	8	P.	P.	NNP
cord-006139-9063uhox	159	9	falciparum	falciparum	NN
cord-006139-9063uhox	159	10	was	be	VBD
cord-006139-9063uhox	159	11	observed	observe	VBN
cord-006139-9063uhox	159	12	.	.	.
cord-006139-9063uhox	160	1	Finally	finally	RB
cord-006139-9063uhox	160	2	,	,	,
cord-006139-9063uhox	160	3	it	-PRON-	PRP
cord-006139-9063uhox	160	4	has	have	VBZ
cord-006139-9063uhox	160	5	also	also	RB
cord-006139-9063uhox	160	6	been	be	VBN
cord-006139-9063uhox	160	7	demonstrated	demonstrate	VBN
cord-006139-9063uhox	160	8	that	that	IN
cord-006139-9063uhox	160	9	these	these	DT
cord-006139-9063uhox	160	10	compounds	compound	NNS
cord-006139-9063uhox	160	11	could	could	MD
cord-006139-9063uhox	160	12	inhibit	inhibit	VB
cord-006139-9063uhox	160	13	b	b	NN
cord-006139-9063uhox	160	14	-	-	HYPH
cord-006139-9063uhox	160	15	hematin	hematin	NN
cord-006139-9063uhox	160	16	formation	formation	NN
cord-006139-9063uhox	160	17	and	and	CC
cord-006139-9063uhox	160	18	decrease	decrease	VB
cord-006139-9063uhox	160	19	hemozoin	hemozoin	NNP
cord-006139-9063uhox	160	20	formation	formation	NN
cord-006139-9063uhox	160	21	within	within	IN
cord-006139-9063uhox	160	22	the	the	DT
cord-006139-9063uhox	160	23	parasite	parasite	NN
cord-006139-9063uhox	160	24	cell	cell	NN
cord-006139-9063uhox	160	25	.	.	.
cord-006139-9063uhox	161	1	The	the	DT
cord-006139-9063uhox	161	2	most	most	RBS
cord-006139-9063uhox	161	3	active	active	JJ
cord-006139-9063uhox	161	4	compound	compound	NN
cord-006139-9063uhox	161	5	was	be	VBD
cord-006139-9063uhox	161	6	also	also	RB
cord-006139-9063uhox	161	7	a	a	DT
cord-006139-9063uhox	161	8	more	more	RBR
cord-006139-9063uhox	161	9	potent	potent	JJ
cord-006139-9063uhox	161	10	hemozoin	hemozoin	JJ
cord-006139-9063uhox	161	11	inhibitor	inhibitor	NN
cord-006139-9063uhox	161	12	than	than	IN
cord-006139-9063uhox	161	13	Compound	Compound	NNP
cord-006139-9063uhox	161	14	1	1	CD
cord-006139-9063uhox	161	15	[	[	-LRB-
cord-006139-9063uhox	161	16	77	77	CD
cord-006139-9063uhox	161	17	]	]	-RRB-
cord-006139-9063uhox	161	18	.	.	.
cord-006139-9063uhox	162	1	Consideration	consideration	NN
cord-006139-9063uhox	162	2	of	of	IN
cord-006139-9063uhox	162	3	the	the	DT
cord-006139-9063uhox	162	4	structures	structure	NNS
cord-006139-9063uhox	162	5	of	of	IN
cord-006139-9063uhox	162	6	these	these	DT
cord-006139-9063uhox	162	7	reversed	reverse	VBN
cord-006139-9063uhox	162	8	chloroquines	chloroquine	NNS
cord-006139-9063uhox	162	9	in	in	IN
cord-006139-9063uhox	162	10	light	light	NN
cord-006139-9063uhox	162	11	of	of	IN
cord-006139-9063uhox	162	12	known	know	VBN
cord-006139-9063uhox	162	13	structure	structure	NN
cord-006139-9063uhox	162	14	-	-	HYPH
cord-006139-9063uhox	162	15	activity	activity	NN
cord-006139-9063uhox	162	16	relationships	relationship	NNS
cord-006139-9063uhox	162	17	for	for	IN
cord-006139-9063uhox	162	18	active	active	JJ
cord-006139-9063uhox	162	19	hemozoininhibiting	hemozoininhibiting	NNP
cord-006139-9063uhox	162	20	quinolines	quinoline	NNS
cord-006139-9063uhox	162	21	,	,	,
cord-006139-9063uhox	162	22	as	as	RB
cord-006139-9063uhox	162	23	well	well	RB
cord-006139-9063uhox	162	24	as	as	IN
cord-006139-9063uhox	162	25	resistance	resistance	NN
cord-006139-9063uhox	162	26	-	-	HYPH
cord-006139-9063uhox	162	27	reversing	reverse	VBG
cord-006139-9063uhox	162	28	chemo	chemo	NN
cord-006139-9063uhox	162	29	sensitizers	sensitizer	NNS
cord-006139-9063uhox	162	30	,	,	,
cord-006139-9063uhox	162	31	permits	permit	VBZ
cord-006139-9063uhox	162	32	rationalization	rationalization	NN
cord-006139-9063uhox	162	33	of	of	IN
cord-006139-9063uhox	162	34	their	-PRON-	PRP$
cord-006139-9063uhox	162	35	structure	structure	NN
cord-006139-9063uhox	162	36	-	-	HYPH
cord-006139-9063uhox	162	37	activity	activity	NN
cord-006139-9063uhox	162	38	relationships	relationship	NNS
cord-006139-9063uhox	162	39	(	(	-LRB-
cord-006139-9063uhox	162	40	Figure	figure	NN
cord-006139-9063uhox	162	41	9	9	CD
cord-006139-9063uhox	162	42	)	)	-RRB-
cord-006139-9063uhox	162	43	.	.	.
cord-006139-9063uhox	163	1	This	this	DT
cord-006139-9063uhox	163	2	approach	approach	NN
cord-006139-9063uhox	163	3	was	be	VBD
cord-006139-9063uhox	163	4	subsequently	subsequently	RB
cord-006139-9063uhox	163	5	used	use	VBN
cord-006139-9063uhox	163	6	in	in	IN
cord-006139-9063uhox	163	7	the	the	DT
cord-006139-9063uhox	163	8	design	design	NN
cord-006139-9063uhox	163	9	of	of	IN
cord-006139-9063uhox	163	10	other	other	JJ
cord-006139-9063uhox	163	11	resistance	resistance	NN
cord-006139-9063uhox	163	12	-	-	HYPH
cord-006139-9063uhox	163	13	reversing	reverse	VBG
cord-006139-9063uhox	163	14	antimalarials	antimalarial	NNS
cord-006139-9063uhox	163	15	.	.	.
cord-006139-9063uhox	164	1	Other	other	JJ
cord-006139-9063uhox	164	2	studies	study	NNS
cord-006139-9063uhox	164	3	have	have	VBP
cord-006139-9063uhox	164	4	built	build	VBN
cord-006139-9063uhox	164	5	on	on	IN
cord-006139-9063uhox	164	6	the	the	DT
cord-006139-9063uhox	164	7	concept	concept	NN
cord-006139-9063uhox	164	8	of	of	IN
cord-006139-9063uhox	164	9	reversed	reversed	JJ
cord-006139-9063uhox	164	10	chloroquines	chloroquine	NNS
cord-006139-9063uhox	164	11	.	.	.
cord-006139-9063uhox	165	1	Dihydropyrimidinones	dihydropyrimidinone	NNS
cord-006139-9063uhox	165	2	are	be	VBP
cord-006139-9063uhox	165	3	a	a	DT
cord-006139-9063uhox	165	4	well	well	RB
cord-006139-9063uhox	165	5	-	-	HYPH
cord-006139-9063uhox	165	6	known	know	VBN
cord-006139-9063uhox	165	7	class	class	NN
cord-006139-9063uhox	165	8	of	of	IN
cord-006139-9063uhox	165	9	calcium	calcium	NN
cord-006139-9063uhox	165	10	channel	channel	NN
cord-006139-9063uhox	165	11	blockers	blocker	NNS
cord-006139-9063uhox	165	12	.	.	.
cord-006139-9063uhox	166	1	Similar	similar	JJ
cord-006139-9063uhox	166	2	to	to	TO
cord-006139-9063uhox	166	3	verapamil	verapamil	VB
cord-006139-9063uhox	166	4	,	,	,
cord-006139-9063uhox	166	5	they	-PRON-	PRP
cord-006139-9063uhox	166	6	are	be	VBP
cord-006139-9063uhox	166	7	capable	capable	JJ
cord-006139-9063uhox	166	8	of	of	IN
cord-006139-9063uhox	166	9	chemosensitizing	chemosensitize	VBG
cord-006139-9063uhox	166	10	multidrug	multidrug	NN
cord-006139-9063uhox	166	11	-	-	HYPH
cord-006139-9063uhox	166	12	resistant	resistant	JJ
cord-006139-9063uhox	166	13	cancer	cancer	NN
cord-006139-9063uhox	166	14	cells	cell	NNS
cord-006139-9063uhox	166	15	.	.	.
cord-006139-9063uhox	167	1	These	these	DT
cord-006139-9063uhox	167	2	molecules	molecule	NNS
cord-006139-9063uhox	167	3	have	have	VBP
cord-006139-9063uhox	167	4	been	be	VBN
cord-006139-9063uhox	167	5	attached	attach	VBN
cord-006139-9063uhox	167	6	to	to	IN
cord-006139-9063uhox	167	7	the	the	DT
cord-006139-9063uhox	167	8	4-amino-7-chloroquinoline	4-amino-7-chloroquinoline	CD
cord-006139-9063uhox	167	9	structure	structure	NN
cord-006139-9063uhox	167	10	to	to	TO
cord-006139-9063uhox	167	11	produce	produce	VB
cord-006139-9063uhox	167	12	a	a	DT
cord-006139-9063uhox	167	13	series	series	NN
cord-006139-9063uhox	167	14	of	of	IN
cord-006139-9063uhox	167	15	compounds	compound	NNS
cord-006139-9063uhox	167	16	(	(	-LRB-
cord-006139-9063uhox	167	17	e.g.	e.g.	RB
cord-006139-9063uhox	167	18	,	,	,
cord-006139-9063uhox	167	19	Compound	Compound	NNP
cord-006139-9063uhox	167	20	3	3	CD
cord-006139-9063uhox	167	21	in	in	IN
cord-006139-9063uhox	167	22	Figure	figure	NN
cord-006139-9063uhox	167	23	10A	10a	CD
cord-006139-9063uhox	167	24	)	)	-RRB-
cord-006139-9063uhox	167	25	with	with	IN
cord-006139-9063uhox	167	26	strong	strong	JJ
cord-006139-9063uhox	167	27	activity	activity	NN
cord-006139-9063uhox	167	28	against	against	IN
cord-006139-9063uhox	167	29	chloroquine	chloroquine	NN
cord-006139-9063uhox	167	30	-	-	HYPH
cord-006139-9063uhox	167	31	resistant	resistant	JJ
cord-006139-9063uhox	167	32	and	and	CC
cord-006139-9063uhox	167	33	-sensitive	-sensitive	JJ
cord-006139-9063uhox	167	34	parasites	parasite	NNS
cord-006139-9063uhox	167	35	[	[	-LRB-
cord-006139-9063uhox	167	36	78	78	CD
cord-006139-9063uhox	167	37	]	]	-RRB-
cord-006139-9063uhox	167	38	.	.	.
cord-006139-9063uhox	168	1	Interestingly	interestingly	RB
cord-006139-9063uhox	168	2	,	,	,
cord-006139-9063uhox	168	3	these	these	DT
cord-006139-9063uhox	168	4	compounds	compound	NNS
cord-006139-9063uhox	168	5	do	do	VBP
cord-006139-9063uhox	168	6	not	not	RB
cord-006139-9063uhox	168	7	have	have	VB
cord-006139-9063uhox	168	8	basic	basic	JJ
cord-006139-9063uhox	168	9	N	n	CD
cord-006139-9063uhox	168	10	atoms	atom	NNS
cord-006139-9063uhox	168	11	in	in	IN
cord-006139-9063uhox	168	12	the	the	DT
cord-006139-9063uhox	168	13	side	side	NN
cord-006139-9063uhox	168	14	chain	chain	NN
cord-006139-9063uhox	168	15	and	and	CC
cord-006139-9063uhox	168	16	therefore	therefore	RB
cord-006139-9063uhox	168	17	do	do	VBP
cord-006139-9063uhox	168	18	not	not	RB
cord-006139-9063uhox	168	19	conform	conform	VB
cord-006139-9063uhox	168	20	to	to	IN
cord-006139-9063uhox	168	21	the	the	DT
cord-006139-9063uhox	168	22	more	more	RBR
cord-006139-9063uhox	168	23	commonly	commonly	RB
cord-006139-9063uhox	168	24	observed	observe	VBN
cord-006139-9063uhox	168	25	structure	structure	NN
cord-006139-9063uhox	168	26	-	-	HYPH
cord-006139-9063uhox	168	27	activity	activity	NN
cord-006139-9063uhox	168	28	relationship	relationship	NN
cord-006139-9063uhox	168	29	model	model	NN
cord-006139-9063uhox	168	30	.	.	.
cord-006139-9063uhox	169	1	Tricyclic	Tricyclic	NNP
cord-006139-9063uhox	169	2	heteroaromatics	heteroaromatic	NNS
cord-006139-9063uhox	169	3	,	,	,
cord-006139-9063uhox	169	4	especially	especially	RB
cord-006139-9063uhox	169	5	phenothiazines	phenothiazine	VBZ
cord-006139-9063uhox	169	6	such	such	JJ
cord-006139-9063uhox	169	7	as	as	IN
cord-006139-9063uhox	169	8	chlorpromazine	chlorpromazine	NN
cord-006139-9063uhox	169	9	(	(	-LRB-
cord-006139-9063uhox	169	10	Compound	Compound	NNP
cord-006139-9063uhox	169	11	4	4	CD
cord-006139-9063uhox	169	12	)	)	-RRB-
cord-006139-9063uhox	169	13	,	,	,
cord-006139-9063uhox	169	14	are	be	VBP
cord-006139-9063uhox	169	15	well	well	RB
cord-006139-9063uhox	169	16	-	-	HYPH
cord-006139-9063uhox	169	17	known	know	VBN
cord-006139-9063uhox	169	18	chloroquine	chloroquine	NN
cord-006139-9063uhox	169	19	chemosensitizers	chemosensitizer	NNS
cord-006139-9063uhox	169	20	.	.	.
cord-006139-9063uhox	170	1	Furthermore	furthermore	RB
cord-006139-9063uhox	170	2	,	,	,
cord-006139-9063uhox	170	3	it	-PRON-	PRP
cord-006139-9063uhox	170	4	has	have	VBZ
cord-006139-9063uhox	170	5	been	be	VBN
cord-006139-9063uhox	170	6	demonstrated	demonstrate	VBN
cord-006139-9063uhox	170	7	that	that	IN
cord-006139-9063uhox	170	8	chlorpromazine	chlorpromazine	NN
cord-006139-9063uhox	170	9	(	(	-LRB-
cord-006139-9063uhox	170	10	Figure	figure	NN
cord-006139-9063uhox	170	11	10B	10b	NN
cord-006139-9063uhox	170	12	)	)	-RRB-
cord-006139-9063uhox	170	13	can	can	MD
cord-006139-9063uhox	170	14	be	be	VB
cord-006139-9063uhox	170	15	modified	modify	VBN
cord-006139-9063uhox	170	16	to	to	TO
cord-006139-9063uhox	170	17	produce	produce	VB
cord-006139-9063uhox	170	18	an	an	DT
cord-006139-9063uhox	170	19	analog	analog	NN
cord-006139-9063uhox	170	20	(	(	-LRB-
cord-006139-9063uhox	170	21	Compound	compound	NN
cord-006139-9063uhox	170	22	5	5	CD
cord-006139-9063uhox	170	23	)	)	-RRB-
cord-006139-9063uhox	170	24	with	with	IN
cord-006139-9063uhox	170	25	antimalarial	antimalarial	JJ
cord-006139-9063uhox	170	26	activity	activity	NN
cord-006139-9063uhox	170	27	with	with	IN
cord-006139-9063uhox	170	28	improved	improved	JJ
cord-006139-9063uhox	170	29	water	water	NN
cord-006139-9063uhox	170	30	solubility	solubility	NN
cord-006139-9063uhox	170	31	and	and	CC
cord-006139-9063uhox	170	32	improved	improve	VBN
cord-006139-9063uhox	170	33	oral	oral	JJ
cord-006139-9063uhox	170	34	bioavailability	bioavailability	NN
cord-006139-9063uhox	170	35	from	from	IN
cord-006139-9063uhox	170	36	the	the	DT
cord-006139-9063uhox	170	37	same	same	JJ
cord-006139-9063uhox	170	38	group	group	NN
cord-006139-9063uhox	170	39	[	[	-LRB-
cord-006139-9063uhox	170	40	76	76	CD
cord-006139-9063uhox	170	41	]	]	-RRB-
cord-006139-9063uhox	170	42	.	.	.
cord-006139-9063uhox	171	1	future	future	JJ
cord-006139-9063uhox	171	2	science	science	NN
cord-006139-9063uhox	171	3	group	group	NN
cord-006139-9063uhox	171	4	by	by	IN
cord-006139-9063uhox	171	5	the	the	DT
cord-006139-9063uhox	171	6	introduction	introduction	NN
cord-006139-9063uhox	171	7	of	of	IN
cord-006139-9063uhox	171	8	an	an	DT
cord-006139-9063uhox	171	9	additional	additional	JJ
cord-006139-9063uhox	171	10	basic	basic	JJ
cord-006139-9063uhox	171	11	amino	amino	NN
cord-006139-9063uhox	171	12	group	group	NN
cord-006139-9063uhox	171	13	(	(	-LRB-
cord-006139-9063uhox	171	14	Figure	figure	NN
cord-006139-9063uhox	171	15	10C	10c	CD
cord-006139-9063uhox	171	16	)	)	-RRB-
cord-006139-9063uhox	171	17	[	[	-LRB-
cord-006139-9063uhox	171	18	49	49	CD
cord-006139-9063uhox	171	19	]	]	-RRB-
cord-006139-9063uhox	171	20	.	.	.
cord-006139-9063uhox	172	1	Kelly	Kelly	NNP
cord-006139-9063uhox	172	2	et	et	NNP
cord-006139-9063uhox	172	3	al	al	NNP
cord-006139-9063uhox	172	4	.	.	.
cord-006139-9063uhox	173	1	later	later	RB
cord-006139-9063uhox	173	2	showed	show	VBD
cord-006139-9063uhox	173	3	that	that	IN
cord-006139-9063uhox	173	4	the	the	DT
cord-006139-9063uhox	173	5	related	relate	VBN
cord-006139-9063uhox	173	6	tricyclic	tricyclic	JJ
cord-006139-9063uhox	173	7	aromatic	aromatic	JJ
cord-006139-9063uhox	173	8	acridones	acridone	NNS
cord-006139-9063uhox	173	9	(	(	-LRB-
cord-006139-9063uhox	173	10	e.g.	e.g.	RB
cord-006139-9063uhox	173	11	,	,	,
cord-006139-9063uhox	173	12	Compound	Compound	NNP
cord-006139-9063uhox	173	13	6	6	CD
cord-006139-9063uhox	173	14	)	)	-RRB-
cord-006139-9063uhox	173	15	also	also	RB
cord-006139-9063uhox	173	16	exhibit	exhibit	VBP
cord-006139-9063uhox	173	17	chloroquine	chloroquine	NN
cord-006139-9063uhox	173	18	chemosensitizing	chemosensitizing	NN
cord-006139-9063uhox	173	19	activity	activity	NN
cord-006139-9063uhox	173	20	(	(	-LRB-
cord-006139-9063uhox	173	21	Figure	figure	NN
cord-006139-9063uhox	173	22	10D	10d	CD
cord-006139-9063uhox	173	23	)	)	-RRB-
cord-006139-9063uhox	174	1	[	[	-LRB-
cord-006139-9063uhox	174	2	79	79	CD
cord-006139-9063uhox	174	3	]	]	-RRB-
cord-006139-9063uhox	174	4	.	.	.
cord-006139-9063uhox	175	1	Subsequently	subsequently	RB
cord-006139-9063uhox	175	2	,	,	,
cord-006139-9063uhox	175	3	these	these	DT
cord-006139-9063uhox	175	4	authors	author	NNS
cord-006139-9063uhox	175	5	went	go	VBD
cord-006139-9063uhox	175	6	on	on	RP
cord-006139-9063uhox	175	7	to	to	TO
cord-006139-9063uhox	175	8	introduce	introduce	VB
cord-006139-9063uhox	175	9	a	a	DT
cord-006139-9063uhox	175	10	further	further	JJ
cord-006139-9063uhox	175	11	weak	weak	JJ
cord-006139-9063uhox	175	12	base	base	NN
cord-006139-9063uhox	175	13	-	-	HYPH
cord-006139-9063uhox	175	14	containing	contain	VBG
cord-006139-9063uhox	175	15	side	side	NN
cord-006139-9063uhox	175	16	chain	chain	NN
cord-006139-9063uhox	175	17	onto	onto	IN
cord-006139-9063uhox	175	18	this	this	DT
cord-006139-9063uhox	175	19	scaffold	scaffold	NN
cord-006139-9063uhox	175	20	to	to	TO
cord-006139-9063uhox	175	21	produce	produce	VB
cord-006139-9063uhox	175	22	a	a	DT
cord-006139-9063uhox	175	23	dual	dual	JJ
cord-006139-9063uhox	175	24	-	-	HYPH
cord-006139-9063uhox	175	25	function	function	NN
cord-006139-9063uhox	175	26	compound	compound	NN
cord-006139-9063uhox	175	27	(	(	-LRB-
cord-006139-9063uhox	175	28	Compound	Compound	NNP
cord-006139-9063uhox	175	29	7	7	CD
cord-006139-9063uhox	175	30	)	)	-RRB-
cord-006139-9063uhox	175	31	that	that	WDT
cord-006139-9063uhox	175	32	exhibited	exhibit	VBD
cord-006139-9063uhox	175	33	antimalarial	antimalarial	JJ
cord-006139-9063uhox	175	34	activity	activity	NN
cord-006139-9063uhox	175	35	(	(	-LRB-
cord-006139-9063uhox	175	36	Figure	figure	NN
cord-006139-9063uhox	175	37	10E	10e	CD
cord-006139-9063uhox	175	38	)	)	-RRB-
cord-006139-9063uhox	176	1	[	[	-LRB-
cord-006139-9063uhox	176	2	80	80	CD
cord-006139-9063uhox	176	3	]	]	-RRB-
cord-006139-9063uhox	176	4	.	.	.
cord-006139-9063uhox	177	1	This	this	DT
cord-006139-9063uhox	177	2	compound	compound	NN
cord-006139-9063uhox	177	3	was	be	VBD
cord-006139-9063uhox	177	4	shown	show	VBN
cord-006139-9063uhox	177	5	to	to	TO
cord-006139-9063uhox	177	6	accumulate	accumulate	VB
cord-006139-9063uhox	177	7	in	in	IN
cord-006139-9063uhox	177	8	the	the	DT
cord-006139-9063uhox	177	9	parasite	parasite	NN
cord-006139-9063uhox	177	10	DV	dv	NN
cord-006139-9063uhox	177	11	by	by	IN
cord-006139-9063uhox	177	12	confocal	confocal	JJ
cord-006139-9063uhox	177	13	fluorescence	fluorescence	NN
cord-006139-9063uhox	177	14	microscopy	microscopy	NNS
cord-006139-9063uhox	177	15	and	and	CC
cord-006139-9063uhox	177	16	to	to	TO
cord-006139-9063uhox	177	17	inhibit	inhibit	VB
cord-006139-9063uhox	177	18	hemozoin	hemozoin	NNP
cord-006139-9063uhox	177	19	formation	formation	NN
cord-006139-9063uhox	177	20	.	.	.
cord-006139-9063uhox	178	1	Isobolograms	Isobolograms	NNP
cord-006139-9063uhox	178	2	were	be	VBD
cord-006139-9063uhox	178	3	used	use	VBN
cord-006139-9063uhox	178	4	to	to	TO
cord-006139-9063uhox	178	5	demonstrate	demonstrate	VB
cord-006139-9063uhox	178	6	that	that	IN
cord-006139-9063uhox	178	7	it	-PRON-	PRP
cord-006139-9063uhox	178	8	exhibited	exhibit	VBD
cord-006139-9063uhox	178	9	an	an	DT
cord-006139-9063uhox	178	10	additive	additive	NN
cord-006139-9063uhox	178	11	relationship	relationship	NN
cord-006139-9063uhox	178	12	when	when	WRB
cord-006139-9063uhox	178	13	mixed	mix	VBN
cord-006139-9063uhox	178	14	with	with	IN
cord-006139-9063uhox	178	15	chloroquine	chloroquine	NN
cord-006139-9063uhox	178	16	in	in	IN
cord-006139-9063uhox	178	17	a	a	DT
cord-006139-9063uhox	178	18	chloroquine	chloroquine	NN
cord-006139-9063uhox	178	19	-	-	HYPH
cord-006139-9063uhox	178	20	sensitive	sensitive	JJ
cord-006139-9063uhox	178	21	P.	P.	NNP
cord-006139-9063uhox	178	22	falciparum	falciparum	NN
cord-006139-9063uhox	178	23	strain	strain	NN
cord-006139-9063uhox	178	24	(	(	-LRB-
cord-006139-9063uhox	178	25	D6	d6	NN
cord-006139-9063uhox	178	26	)	)	-RRB-
cord-006139-9063uhox	178	27	,	,	,
cord-006139-9063uhox	178	28	but	but	CC
cord-006139-9063uhox	178	29	was	be	VBD
cord-006139-9063uhox	178	30	synergistic	synergistic	JJ
cord-006139-9063uhox	178	31	in	in	IN
cord-006139-9063uhox	178	32	the	the	DT
cord-006139-9063uhox	178	33	chloroquine	chloroquine	NN
cord-006139-9063uhox	178	34	-	-	HYPH
cord-006139-9063uhox	178	35	resistant	resistant	JJ
cord-006139-9063uhox	178	36	Dd2	dd2	NN
cord-006139-9063uhox	178	37	strain	strain	NN
cord-006139-9063uhox	178	38	.	.	.
cord-006139-9063uhox	179	1	This	this	DT
cord-006139-9063uhox	179	2	observation	observation	NN
cord-006139-9063uhox	179	3	is	be	VBZ
cord-006139-9063uhox	179	4	consistent	consistent	JJ
cord-006139-9063uhox	179	5	with	with	IN
cord-006139-9063uhox	179	6	that	that	DT
cord-006139-9063uhox	179	7	expected	expect	VBN
cord-006139-9063uhox	179	8	if	if	IN
cord-006139-9063uhox	179	9	the	the	DT
cord-006139-9063uhox	179	10	compound	compound	NN
cord-006139-9063uhox	179	11	acts	act	VBZ
cord-006139-9063uhox	179	12	as	as	IN
cord-006139-9063uhox	179	13	a	a	DT
cord-006139-9063uhox	179	14	chemosensitizer	chemosensitizer	NN
cord-006139-9063uhox	179	15	in	in	IN
cord-006139-9063uhox	179	16	chloroquine	chloroquine	NN
cord-006139-9063uhox	179	17	-	-	HYPH
cord-006139-9063uhox	179	18	resistant	resistant	JJ
cord-006139-9063uhox	179	19	parasites	parasite	NNS
cord-006139-9063uhox	179	20	and	and	CC
cord-006139-9063uhox	179	21	also	also	RB
cord-006139-9063uhox	179	22	acts	act	VBZ
cord-006139-9063uhox	179	23	as	as	IN
cord-006139-9063uhox	179	24	an	an	DT
cord-006139-9063uhox	179	25	antimalarial	antimalarial	JJ
cord-006139-9063uhox	179	26	in	in	IN
cord-006139-9063uhox	179	27	a	a	DT
cord-006139-9063uhox	179	28	manner	manner	NN
cord-006139-9063uhox	179	29	similar	similar	JJ
cord-006139-9063uhox	179	30	to	to	IN
cord-006139-9063uhox	179	31	chloroquine	chloroquine	NN
cord-006139-9063uhox	179	32	.	.	.
cord-006139-9063uhox	180	1	This	this	DT
cord-006139-9063uhox	180	2	compound	compound	NN
cord-006139-9063uhox	180	3	exhibited	exhibit	VBD
cord-006139-9063uhox	180	4	excellent	excellent	JJ
cord-006139-9063uhox	180	5	activity	activity	NN
cord-006139-9063uhox	180	6	against	against	IN
cord-006139-9063uhox	180	7	chloroquine	chloroquine	NN
cord-006139-9063uhox	180	8	-	-	HYPH
cord-006139-9063uhox	180	9	sensitive	sensitive	JJ
cord-006139-9063uhox	180	10	and	and	CC
cord-006139-9063uhox	180	11	-resistant	-resistant	JJ
cord-006139-9063uhox	180	12	parasites	parasite	NNS
cord-006139-9063uhox	180	13	and	and	CC
cord-006139-9063uhox	180	14	was	be	VBD
cord-006139-9063uhox	180	15	active	active	JJ
cord-006139-9063uhox	180	16	in	in	IN
cord-006139-9063uhox	180	17	vivo	vivo	NNP
cord-006139-9063uhox	180	18	.	.	.
cord-006139-9063uhox	181	1	A	a	DT
cord-006139-9063uhox	181	2	recent	recent	JJ
cord-006139-9063uhox	181	3	addition	addition	NN
cord-006139-9063uhox	181	4	to	to	IN
cord-006139-9063uhox	181	5	the	the	DT
cord-006139-9063uhox	181	6	class	class	NN
cord-006139-9063uhox	181	7	of	of	IN
cord-006139-9063uhox	181	8	dual	dual	JJ
cord-006139-9063uhox	181	9	-	-	HYPH
cord-006139-9063uhox	181	10	function	function	NN
cord-006139-9063uhox	181	11	quinolines	quinoline	NNS
cord-006139-9063uhox	181	12	that	that	WDT
cord-006139-9063uhox	181	13	have	have	VBP
cord-006139-9063uhox	181	14	resistance	resistance	NN
cord-006139-9063uhox	181	15	-	-	HYPH
cord-006139-9063uhox	181	16	reversing	reverse	VBG
cord-006139-9063uhox	181	17	activity	activity	NN
cord-006139-9063uhox	181	18	is	be	VBZ
cord-006139-9063uhox	181	19	the	the	DT
cord-006139-9063uhox	181	20	dibemequines	dibemequine	NNS
cord-006139-9063uhox	181	21	[	[	-LRB-
cord-006139-9063uhox	181	22	81	81	CD
cord-006139-9063uhox	181	23	]	]	-RRB-
cord-006139-9063uhox	181	24	,	,	,
cord-006139-9063uhox	181	25	consisting	consist	VBG
cord-006139-9063uhox	181	26	of	of	IN
cord-006139-9063uhox	181	27	a	a	DT
cord-006139-9063uhox	181	28	4-amino-7-chloroquinoline	4-amino-7-chloroquinoline	CD
cord-006139-9063uhox	181	29	with	with	IN
cord-006139-9063uhox	181	30	a	a	DT
cord-006139-9063uhox	181	31	dibemethin	dibemethin	NN
cord-006139-9063uhox	181	32	(	(	-LRB-
cord-006139-9063uhox	181	33	dibenzylmethylamine	dibenzylmethylamine	NNP
cord-006139-9063uhox	181	34	)	)	-RRB-
cord-006139-9063uhox	181	35	side	side	NN
cord-006139-9063uhox	181	36	chain	chain	NN
cord-006139-9063uhox	181	37	.	.	.
cord-006139-9063uhox	182	1	These	these	DT
cord-006139-9063uhox	182	2	were	be	VBD
cord-006139-9063uhox	182	3	designed	design	VBN
cord-006139-9063uhox	182	4	to	to	TO
cord-006139-9063uhox	182	5	fulfill	fulfill	VB
cord-006139-9063uhox	182	6	the	the	DT
cord-006139-9063uhox	182	7	structure	structure	NN
cord-006139-9063uhox	182	8	-	-	HYPH
cord-006139-9063uhox	182	9	activity	activity	NN
cord-006139-9063uhox	182	10	relationship	relationship	NN
cord-006139-9063uhox	182	11	criteria	criterion	NNS
cord-006139-9063uhox	182	12	of	of	IN
cord-006139-9063uhox	182	13	both	both	CC
cord-006139-9063uhox	182	14	an	an	DT
cord-006139-9063uhox	182	15	active	active	JJ
cord-006139-9063uhox	182	16	hemozoin	hemozoin	NN
cord-006139-9063uhox	182	17	-	-	HYPH
cord-006139-9063uhox	182	18	inhibiting	inhibit	VBG
cord-006139-9063uhox	182	19	quinoline	quinoline	NN
cord-006139-9063uhox	182	20	antimalarial	antimalarial	JJ
cord-006139-9063uhox	182	21	and	and	CC
cord-006139-9063uhox	182	22	a	a	DT
cord-006139-9063uhox	182	23	chloroquine	chloroquine	NN
cord-006139-9063uhox	182	24	N	N	NNP
cord-006139-9063uhox	182	25	N	N	NNP
cord-006139-9063uhox	182	26	Cl	Cl	NNP
cord-006139-9063uhox	182	27	HN	HN	NNP
cord-006139-9063uhox	182	28	N	N	NNP
cord-006139-9063uhox	182	29	Figure	Figure	NNP
cord-006139-9063uhox	182	30	9	9	CD
cord-006139-9063uhox	182	31	.	.	.
cord-006139-9063uhox	183	1	Rationalization	rationalization	NN
cord-006139-9063uhox	183	2	of	of	IN
cord-006139-9063uhox	183	3	the	the	DT
cord-006139-9063uhox	183	4	structure	structure	NN
cord-006139-9063uhox	183	5	-	-	HYPH
cord-006139-9063uhox	183	6	activity	activity	NN
cord-006139-9063uhox	183	7	relationships	relationship	NNS
cord-006139-9063uhox	183	8	in	in	IN
cord-006139-9063uhox	183	9	the	the	DT
cord-006139-9063uhox	183	10	reversed	reverse	VBN
cord-006139-9063uhox	183	11	chloroquines	chloroquine	NNS
cord-006139-9063uhox	183	12	.	.	.
cord-006139-9063uhox	184	1	The	the	DT
cord-006139-9063uhox	184	2	parts	part	NNS
cord-006139-9063uhox	184	3	of	of	IN
cord-006139-9063uhox	184	4	the	the	DT
cord-006139-9063uhox	184	5	molecule	molecule	NN
cord-006139-9063uhox	184	6	highlighted	highlight	VBN
cord-006139-9063uhox	184	7	are	be	VBP
cord-006139-9063uhox	184	8	the	the	DT
cord-006139-9063uhox	184	9	4-aminoquinoline	4-aminoquinoline	CD
cord-006139-9063uhox	184	10	moiety	moiety	NN
cord-006139-9063uhox	184	11	required	require	VBN
cord-006139-9063uhox	184	12	for	for	IN
cord-006139-9063uhox	184	13	Fe(III)heme	fe(iii)heme	DT
cord-006139-9063uhox	184	14	binding	binding	NN
cord-006139-9063uhox	184	15	,	,	,
cord-006139-9063uhox	184	16	the	the	DT
cord-006139-9063uhox	184	17	Cl	Cl	NNP
cord-006139-9063uhox	184	18	atom	atom	NN
cord-006139-9063uhox	184	19	required	require	VBN
cord-006139-9063uhox	184	20	for	for	IN
cord-006139-9063uhox	184	21	hemozoin	hemozoin	NNP
cord-006139-9063uhox	184	22	inhibition	inhibition	NN
cord-006139-9063uhox	184	23	,	,	,
cord-006139-9063uhox	184	24	the	the	DT
cord-006139-9063uhox	184	25	basic	basic	JJ
cord-006139-9063uhox	184	26	tertiary	tertiary	JJ
cord-006139-9063uhox	184	27	N	n	CD
cord-006139-9063uhox	184	28	atom	atom	NN
cord-006139-9063uhox	184	29	that	that	WDT
cord-006139-9063uhox	184	30	aids	aid	VBZ
cord-006139-9063uhox	184	31	accumulation	accumulation	NN
cord-006139-9063uhox	184	32	in	in	IN
cord-006139-9063uhox	184	33	the	the	DT
cord-006139-9063uhox	184	34	digestive	digestive	JJ
cord-006139-9063uhox	184	35	vacuole	vacuole	NN
cord-006139-9063uhox	184	36	(	(	-LRB-
cord-006139-9063uhox	184	37	see	see	VB
cord-006139-9063uhox	184	38	Figure	figure	NN
cord-006139-9063uhox	184	39	5	5	CD
cord-006139-9063uhox	184	40	)	)	-RRB-
cord-006139-9063uhox	184	41	and	and	CC
cord-006139-9063uhox	184	42	the	the	DT
cord-006139-9063uhox	184	43	two	two	CD
cord-006139-9063uhox	184	44	aromatic	aromatic	JJ
cord-006139-9063uhox	184	45	rings	ring	NNS
cord-006139-9063uhox	184	46	and	and	CC
cord-006139-9063uhox	184	47	hydrogen	hydrogen	NN
cord-006139-9063uhox	184	48	bond	bond	NN
cord-006139-9063uhox	184	49	acceptor	acceptor	NN
cord-006139-9063uhox	184	50	required	require	VBN
cord-006139-9063uhox	184	51	for	for	IN
cord-006139-9063uhox	184	52	a	a	DT
cord-006139-9063uhox	184	53	chloroquine	chloroquine	NN
cord-006139-9063uhox	184	54	chemosensitizer	chemosensitizer	NN
cord-006139-9063uhox	184	55	(	(	-LRB-
cord-006139-9063uhox	184	56	see	see	VB
cord-006139-9063uhox	184	57	Figure	Figure	NNP
cord-006139-9063uhox	184	58	7	7	CD
cord-006139-9063uhox	184	59	)	)	-RRB-
cord-006139-9063uhox	184	60	.	.	.
cord-006139-9063uhox	185	1	[	[	-LRB-
cord-006139-9063uhox	185	2	79	79	CD
cord-006139-9063uhox	185	3	]	]	-RRB-
cord-006139-9063uhox	185	4	.	.	.
cord-006139-9063uhox	186	1	(	(	-LRB-
cord-006139-9063uhox	186	2	E	e	NN
cord-006139-9063uhox	186	3	)	)	-RRB-
cord-006139-9063uhox	187	1	A	a	DT
cord-006139-9063uhox	187	2	dual	dual	JJ
cord-006139-9063uhox	187	3	-	-	HYPH
cord-006139-9063uhox	187	4	function	function	NN
cord-006139-9063uhox	187	5	acridone	acridone	NN
cord-006139-9063uhox	187	6	(	(	-LRB-
cord-006139-9063uhox	187	7	Compound	Compound	NNP
cord-006139-9063uhox	187	8	7	7	CD
cord-006139-9063uhox	187	9	)	)	-RRB-
cord-006139-9063uhox	187	10	that	that	IN
cord-006139-9063uhox	187	11	both	both	DT
cord-006139-9063uhox	187	12	reverses	reverse	VBZ
cord-006139-9063uhox	187	13	chloroquine	chloroquine	NN
cord-006139-9063uhox	187	14	resistance	resistance	NN
cord-006139-9063uhox	187	15	and	and	CC
cord-006139-9063uhox	187	16	is	be	VBZ
cord-006139-9063uhox	187	17	an	an	DT
cord-006139-9063uhox	187	18	active	active	JJ
cord-006139-9063uhox	187	19	antimalarial	antimalarial	JJ
cord-006139-9063uhox	187	20	[	[	-LRB-
cord-006139-9063uhox	187	21	80	80	CD
cord-006139-9063uhox	187	22	]	]	-RRB-
cord-006139-9063uhox	187	23	.	.	.
cord-006139-9063uhox	188	1	future	future	JJ
cord-006139-9063uhox	188	2	science	science	NN
cord-006139-9063uhox	188	3	group	group	NN
cord-006139-9063uhox	188	4	chemosensitizer	chemosensitizer	NNP
cord-006139-9063uhox	188	5	(	(	-LRB-
cord-006139-9063uhox	188	6	Figure	Figure	NNP
cord-006139-9063uhox	188	7	11	11	CD
cord-006139-9063uhox	188	8	)	)	-RRB-
cord-006139-9063uhox	188	9	.	.	.
cord-006139-9063uhox	189	1	The	the	DT
cord-006139-9063uhox	189	2	dibemethin	dibemethin	NN
cord-006139-9063uhox	189	3	side	side	NN
cord-006139-9063uhox	189	4	chains	chain	NNS
cord-006139-9063uhox	189	5	themselves	-PRON-	PRP
cord-006139-9063uhox	189	6	were	be	VBD
cord-006139-9063uhox	189	7	found	find	VBN
cord-006139-9063uhox	189	8	to	to	TO
cord-006139-9063uhox	189	9	reverse	reverse	VB
cord-006139-9063uhox	189	10	chloroquine	chloroquine	NN
cord-006139-9063uhox	189	11	resistance	resistance	NN
cord-006139-9063uhox	189	12	and	and	CC
cord-006139-9063uhox	189	13	to	to	TO
cord-006139-9063uhox	189	14	inhibit	inhibit	VB
cord-006139-9063uhox	189	15	chloroquine	chloroquine	NN
cord-006139-9063uhox	189	16	transport	transport	NN
cord-006139-9063uhox	189	17	by	by	IN
cord-006139-9063uhox	189	18	PfCRT	PfCRT	NNP
cord-006139-9063uhox	189	19	[	[	-LRB-
cord-006139-9063uhox	189	20	72	72	CD
cord-006139-9063uhox	189	21	]	]	-RRB-
cord-006139-9063uhox	189	22	.	.	.
cord-006139-9063uhox	190	1	The	the	DT
cord-006139-9063uhox	190	2	crystal	crystal	JJ
cord-006139-9063uhox	190	3	structure	structure	NN
cord-006139-9063uhox	190	4	of	of	IN
cord-006139-9063uhox	190	5	the	the	DT
cord-006139-9063uhox	190	6	prototype	prototype	NN
cord-006139-9063uhox	190	7	dibemequine	dibemequine	NN
cord-006139-9063uhox	190	8	(	(	-LRB-
cord-006139-9063uhox	190	9	Compound	Compound	NNP
cord-006139-9063uhox	190	10	8)	8)	NN
cord-006139-9063uhox	190	11	demonstrated	demonstrate	VBD
cord-006139-9063uhox	190	12	the	the	DT
cord-006139-9063uhox	190	13	structural	structural	JJ
cord-006139-9063uhox	190	14	requirements	requirement	NNS
cord-006139-9063uhox	190	15	for	for	IN
cord-006139-9063uhox	190	16	a	a	DT
cord-006139-9063uhox	190	17	resistance	resistance	NN
cord-006139-9063uhox	190	18	future	future	JJ
cord-006139-9063uhox	190	19	science	science	NN
cord-006139-9063uhox	190	20	group	group	NN
cord-006139-9063uhox	190	21	reverser	reverser	NN
cord-006139-9063uhox	190	22	,	,	,
cord-006139-9063uhox	190	23	with	with	IN
cord-006139-9063uhox	190	24	the	the	DT
cord-006139-9063uhox	190	25	quinoline	quinoline	NNP
cord-006139-9063uhox	190	26	group	group	NN
cord-006139-9063uhox	190	27	folded	fold	VBD
cord-006139-9063uhox	190	28	around	around	RB
cord-006139-9063uhox	190	29	to	to	TO
cord-006139-9063uhox	190	30	establish	establish	VB
cord-006139-9063uhox	190	31	an	an	DT
cord-006139-9063uhox	190	32	approximately	approximately	RB
cord-006139-9063uhox	190	33	triangular	triangular	JJ
cord-006139-9063uhox	190	34	relationship	relationship	NN
cord-006139-9063uhox	190	35	between	between	IN
cord-006139-9063uhox	190	36	the	the	DT
cord-006139-9063uhox	190	37	quinoline	quinoline	NNP
cord-006139-9063uhox	190	38	N	N	NNP
cord-006139-9063uhox	190	39	atom	atom	NN
cord-006139-9063uhox	190	40	and	and	CC
cord-006139-9063uhox	190	41	the	the	DT
cord-006139-9063uhox	190	42	two	two	CD
cord-006139-9063uhox	190	43	phenyl	phenyl	NNP
cord-006139-9063uhox	190	44	groups	group	NNS
cord-006139-9063uhox	190	45	of	of	IN
cord-006139-9063uhox	190	46	the	the	DT
cord-006139-9063uhox	190	47	dibemethin	dibemethin	NNP
cord-006139-9063uhox	190	48	side	side	NN
cord-006139-9063uhox	190	49	chain	chain	NN
cord-006139-9063uhox	190	50	.	.	.
cord-006139-9063uhox	191	1	This	this	DT
cord-006139-9063uhox	191	2	compound	compound	NN
cord-006139-9063uhox	191	3	was	be	VBD
cord-006139-9063uhox	191	4	shown	show	VBN
cord-006139-9063uhox	191	5	to	to	TO
cord-006139-9063uhox	191	6	directly	directly	RB
cord-006139-9063uhox	191	7	inhibit	inhibit	VB
cord-006139-9063uhox	191	8	chloroquine	chloroquine	NN
cord-006139-9063uhox	191	9	transport	transport	NN
cord-006139-9063uhox	191	10	by	by	IN
cord-006139-9063uhox	191	11	PfCRT	PfCRT	NNP
cord-006139-9063uhox	191	12	in	in	IN
cord-006139-9063uhox	191	13	the	the	DT
cord-006139-9063uhox	191	14	Xenopus	Xenopus	NNP
cord-006139-9063uhox	191	15	oocyte	oocyte	NN
cord-006139-9063uhox	191	16	model	model	NN
cord-006139-9063uhox	191	17	(	(	-LRB-
cord-006139-9063uhox	191	18	Figure	figure	NN
cord-006139-9063uhox	191	19	11B	11b	CD
cord-006139-9063uhox	191	20	)	)	-RRB-
cord-006139-9063uhox	191	21	.	.	.
cord-006139-9063uhox	192	1	Two	two	CD
cord-006139-9063uhox	192	2	analogs	analog	NNS
cord-006139-9063uhox	192	3	(	(	-LRB-
cord-006139-9063uhox	192	4	Compounds	compound	NNS
cord-006139-9063uhox	192	5	9	9	CD
cord-006139-9063uhox	192	6	&	&	CC
cord-006139-9063uhox	192	7	10	10	CD
cord-006139-9063uhox	192	8	)	)	-RRB-
cord-006139-9063uhox	192	9	were	be	VBD
cord-006139-9063uhox	192	10	also	also	RB
cord-006139-9063uhox	192	11	shown	show	VBN
cord-006139-9063uhox	192	12	to	to	TO
cord-006139-9063uhox	192	13	exhibit	exhibit	VB
cord-006139-9063uhox	192	14	such	such	JJ
cord-006139-9063uhox	192	15	activity	activity	NN
cord-006139-9063uhox	192	16	(	(	-LRB-
cord-006139-9063uhox	192	17	Figure	figure	NN
cord-006139-9063uhox	192	18	11C	11c	CD
cord-006139-9063uhox	192	19	)	)	-RRB-
cord-006139-9063uhox	192	20	.	.	.
cord-006139-9063uhox	193	1	These	these	DT
cord-006139-9063uhox	193	2	represent	represent	VBP
cord-006139-9063uhox	193	3	the	the	DT
cord-006139-9063uhox	193	4	first	first	JJ
cord-006139-9063uhox	193	5	blood	blood	NN
cord-006139-9063uhox	193	6	-	-	HYPH
cord-006139-9063uhox	193	7	stage	stage	NN
cord-006139-9063uhox	193	8	antimalarially	antimalarially	NN
cord-006139-9063uhox	193	9	active	active	JJ
cord-006139-9063uhox	193	10	compounds	compound	NNS
cord-006139-9063uhox	193	11	for	for	IN
cord-006139-9063uhox	193	12	which	which	WDT
cord-006139-9063uhox	193	13	direct	direct	JJ
cord-006139-9063uhox	193	14	evidence	evidence	NN
cord-006139-9063uhox	193	15	of	of	IN
cord-006139-9063uhox	193	16	the	the	DT
cord-006139-9063uhox	193	17	inhibition	inhibition	NN
cord-006139-9063uhox	193	18	of	of	IN
cord-006139-9063uhox	193	19	chloroquine	chloroquine	NN
cord-006139-9063uhox	193	20	transport	transport	NN
cord-006139-9063uhox	193	21	by	by	IN
cord-006139-9063uhox	193	22	PfCRT	PfCRT	NNP
cord-006139-9063uhox	193	23	has	have	VBZ
cord-006139-9063uhox	193	24	been	be	VBN
cord-006139-9063uhox	193	25	provided	provide	VBN
cord-006139-9063uhox	193	26	.	.	.
cord-006139-9063uhox	194	1	Isobologram	Isobologram	NNP
cord-006139-9063uhox	194	2	ana	ana	NNP
cord-006139-9063uhox	194	3	lysis	lysis	NN
cord-006139-9063uhox	194	4	of	of	IN
cord-006139-9063uhox	194	5	Compound	Compound	NNP
cord-006139-9063uhox	194	6	10	10	CD
cord-006139-9063uhox	194	7	revealed	reveal	VBD
cord-006139-9063uhox	194	8	an	an	DT
cord-006139-9063uhox	194	9	additive	additive	NN
cord-006139-9063uhox	194	10	relationship	relationship	NN
cord-006139-9063uhox	194	11	with	with	IN
cord-006139-9063uhox	194	12	chloroquine	chloroquine	NN
cord-006139-9063uhox	194	13	in	in	IN
cord-006139-9063uhox	194	14	the	the	DT
cord-006139-9063uhox	194	15	chloroquine	chloroquine	NN
cord-006139-9063uhox	194	16	-	-	HYPH
cord-006139-9063uhox	194	17	sensitive	sensitive	JJ
cord-006139-9063uhox	194	18	D10	D10	NNP
cord-006139-9063uhox	194	19	strain	strain	NN
cord-006139-9063uhox	194	20	of	of	IN
cord-006139-9063uhox	194	21	parasite	parasite	NN
cord-006139-9063uhox	194	22	,	,	,
cord-006139-9063uhox	194	23	but	but	CC
cord-006139-9063uhox	194	24	a	a	DT
cord-006139-9063uhox	194	25	synergistic	synergistic	JJ
cord-006139-9063uhox	194	26	relationship	relationship	NN
cord-006139-9063uhox	194	27	in	in	IN
cord-006139-9063uhox	194	28	the	the	DT
cord-006139-9063uhox	194	29	chloroquineresistant	chloroquineresistant	NN
cord-006139-9063uhox	194	30	Dd2	Dd2	NNP
cord-006139-9063uhox	194	31	strain	strain	NN
cord-006139-9063uhox	194	32	.	.	.
cord-006139-9063uhox	195	1	This	this	DT
cord-006139-9063uhox	195	2	strongly	strongly	RB
cord-006139-9063uhox	195	3	supported	support	VBD
cord-006139-9063uhox	195	4	the	the	DT
cord-006139-9063uhox	195	5	hypothesis	hypothesis	NN
cord-006139-9063uhox	195	6	that	that	IN
cord-006139-9063uhox	195	7	this	this	DT
cord-006139-9063uhox	195	8	class	class	NN
cord-006139-9063uhox	195	9	of	of	IN
cord-006139-9063uhox	195	10	compound	compound	NN
cord-006139-9063uhox	195	11	inhibits	inhibit	VBZ
cord-006139-9063uhox	195	12	PfCRT	PfCRT	NNP
cord-006139-9063uhox	195	13	in	in	IN
cord-006139-9063uhox	195	14	the	the	DT
cord-006139-9063uhox	195	15	parasite	parasite	NN
cord-006139-9063uhox	195	16	under	under	IN
cord-006139-9063uhox	195	17	conditions	condition	NNS
cord-006139-9063uhox	195	18	in	in	IN
cord-006139-9063uhox	195	19	which	which	WDT
cord-006139-9063uhox	195	20	it	-PRON-	PRP
cord-006139-9063uhox	195	21	inhibits	inhibit	VBZ
cord-006139-9063uhox	195	22	parasite	parasite	NN
cord-006139-9063uhox	195	23	growth	growth	NN
cord-006139-9063uhox	195	24	.	.	.
cord-006139-9063uhox	196	1	These	these	DT
cord-006139-9063uhox	196	2	compounds	compound	NNS
cord-006139-9063uhox	196	3	were	be	VBD
cord-006139-9063uhox	196	4	also	also	RB
cord-006139-9063uhox	196	5	shown	show	VBN
cord-006139-9063uhox	196	6	to	to	TO
cord-006139-9063uhox	196	7	inhibit	inhibit	VB
cord-006139-9063uhox	196	8	b	b	NN
cord-006139-9063uhox	196	9	-	-	HYPH
cord-006139-9063uhox	196	10	hematin	hematin	NN
cord-006139-9063uhox	196	11	formation	formation	NN
cord-006139-9063uhox	196	12	,	,	,
cord-006139-9063uhox	196	13	thus	thus	RB
cord-006139-9063uhox	196	14	also	also	RB
cord-006139-9063uhox	196	15	supporting	support	VBG
cord-006139-9063uhox	196	16	the	the	DT
cord-006139-9063uhox	196	17	hypothesis	hypothesis	NN
cord-006139-9063uhox	196	18	that	that	IN
cord-006139-9063uhox	196	19	their	-PRON-	PRP$
cord-006139-9063uhox	196	20	activity	activity	NN
cord-006139-9063uhox	196	21	against	against	IN
cord-006139-9063uhox	196	22	malaria	malaria	NN
cord-006139-9063uhox	196	23	parasites	parasite	NNS
cord-006139-9063uhox	196	24	is	be	VBZ
cord-006139-9063uhox	196	25	linked	link	VBN
cord-006139-9063uhox	196	26	to	to	IN
cord-006139-9063uhox	196	27	inhibition	inhibition	NN
cord-006139-9063uhox	196	28	of	of	IN
cord-006139-9063uhox	196	29	hemozoin	hemozoin	NNP
cord-006139-9063uhox	196	30	formation	formation	NN
cord-006139-9063uhox	196	31	.	.	.
cord-006139-9063uhox	197	1	Indeed	indeed	RB
cord-006139-9063uhox	197	2	,	,	,
cord-006139-9063uhox	197	3	their	-PRON-	PRP$
cord-006139-9063uhox	197	4	biological	biological	JJ
cord-006139-9063uhox	197	5	activity	activity	NN
cord-006139-9063uhox	197	6	against	against	IN
cord-006139-9063uhox	197	7	P.	P.	NNP
cord-006139-9063uhox	197	8	falciparum	falciparum	NN
cord-006139-9063uhox	197	9	cultured	culture	VBN
cord-006139-9063uhox	197	10	in	in	IN
cord-006139-9063uhox	197	11	vitro	vitro	FW
cord-006139-9063uhox	197	12	was	be	VBD
cord-006139-9063uhox	197	13	found	find	VBN
cord-006139-9063uhox	197	14	to	to	TO
cord-006139-9063uhox	197	15	be	be	VB
cord-006139-9063uhox	197	16	correlated	correlate	VBN
cord-006139-9063uhox	197	17	with	with	IN
cord-006139-9063uhox	197	18	b	b	NN
cord-006139-9063uhox	197	19	-	-	HYPH
cord-006139-9063uhox	197	20	hematin	hematin	NN
cord-006139-9063uhox	197	21	inhibitory	inhibitory	JJ
cord-006139-9063uhox	197	22	activity	activity	NN
cord-006139-9063uhox	197	23	,	,	,
cord-006139-9063uhox	197	24	albeit	albeit	IN
cord-006139-9063uhox	197	25	in	in	IN
cord-006139-9063uhox	197	26	combination	combination	NN
cord-006139-9063uhox	197	27	with	with	IN
cord-006139-9063uhox	197	28	the	the	DT
cord-006139-9063uhox	197	29	predicted	predict	VBN
cord-006139-9063uhox	197	30	DV	DV	NNP
cord-006139-9063uhox	197	31	accumulation	accumulation	NN
cord-006139-9063uhox	197	32	ratio	ratio	NN
cord-006139-9063uhox	197	33	and	and	CC
cord-006139-9063uhox	197	34	substitution	substitution	NN
cord-006139-9063uhox	197	35	pattern	pattern	NN
cord-006139-9063uhox	197	36	in	in	IN
cord-006139-9063uhox	197	37	the	the	DT
cord-006139-9063uhox	197	38	dibemethin	dibemethin	NN
cord-006139-9063uhox	197	39	side	side	NN
cord-006139-9063uhox	197	40	chain	chain	NN
cord-006139-9063uhox	197	41	,	,	,
cord-006139-9063uhox	197	42	with	with	IN
cord-006139-9063uhox	197	43	F	F	NNP
cord-006139-9063uhox	197	44	=	=	NN
cord-006139-9063uhox	197	45	9.70	9.70	CD
cord-006139-9063uhox	197	46	>	>	XX
cord-006139-9063uhox	198	1	F	F	NNP
cord-006139-9063uhox	198	2	0.95	0.95	CD
cord-006139-9063uhox	198	3	=	=	SYM
cord-006139-9063uhox	198	4	8.45	8.45	CD
cord-006139-9063uhox	199	1	(	(	-LRB-
cord-006139-9063uhox	199	2	Figure	figure	NN
cord-006139-9063uhox	199	3	11D	11d	CD
cord-006139-9063uhox	199	4	)	)	-RRB-
cord-006139-9063uhox	199	5	.	.	.
cord-006139-9063uhox	200	1	The	the	DT
cord-006139-9063uhox	200	2	dibemequines	dibemequine	NNS
cord-006139-9063uhox	200	3	tested	test	VBN
cord-006139-9063uhox	200	4	for	for	IN
cord-006139-9063uhox	200	5	cytotoxicity	cytotoxicity	NN
cord-006139-9063uhox	200	6	,	,	,
cord-006139-9063uhox	200	7	which	which	WDT
cord-006139-9063uhox	200	8	included	include	VBD
cord-006139-9063uhox	200	9	the	the	DT
cord-006139-9063uhox	200	10	three	three	CD
cord-006139-9063uhox	200	11	most	most	RBS
cord-006139-9063uhox	200	12	active	active	JJ
cord-006139-9063uhox	200	13	derivatives	derivative	NNS
cord-006139-9063uhox	200	14	,	,	,
cord-006139-9063uhox	200	15	were	be	VBD
cord-006139-9063uhox	200	16	found	find	VBN
cord-006139-9063uhox	200	17	to	to	TO
cord-006139-9063uhox	200	18	have	have	VB
cord-006139-9063uhox	200	19	low	low	JJ
cord-006139-9063uhox	200	20	cytotoxicity	cytotoxicity	NN
cord-006139-9063uhox	200	21	,	,	,
cord-006139-9063uhox	200	22	with	with	IN
cord-006139-9063uhox	200	23	selectivity	selectivity	NN
cord-006139-9063uhox	200	24	indices	index	NNS
cord-006139-9063uhox	200	25	well	well	RB
cord-006139-9063uhox	200	26	above	above	IN
cord-006139-9063uhox	200	27	1000	1000	CD
cord-006139-9063uhox	200	28	.	.	.
cord-006139-9063uhox	201	1	The	the	DT
cord-006139-9063uhox	201	2	whole	whole	JJ
cord-006139-9063uhox	201	3	series	series	NN
cord-006139-9063uhox	201	4	was	be	VBD
cord-006139-9063uhox	201	5	found	find	VBN
cord-006139-9063uhox	201	6	to	to	TO
cord-006139-9063uhox	201	7	show	show	VB
cord-006139-9063uhox	201	8	little	little	JJ
cord-006139-9063uhox	201	9	cross	cross	NN
cord-006139-9063uhox	201	10	-	-	NN
cord-006139-9063uhox	201	11	resistance	resistance	NN
cord-006139-9063uhox	201	12	with	with	IN
cord-006139-9063uhox	201	13	chloroquine	chloroquine	NN
cord-006139-9063uhox	201	14	in	in	IN
cord-006139-9063uhox	201	15	the	the	DT
cord-006139-9063uhox	201	16	K1	K1	NNP
cord-006139-9063uhox	201	17	strain	strain	NN
cord-006139-9063uhox	201	18	of	of	IN
cord-006139-9063uhox	201	19	chloroquine	chloroquine	NN
cord-006139-9063uhox	201	20	-	-	HYPH
cord-006139-9063uhox	201	21	resistant	resistant	JJ
cord-006139-9063uhox	201	22	parasite	parasite	NN
cord-006139-9063uhox	201	23	.	.	.
cord-006139-9063uhox	202	1	Compound	compound	NN
cord-006139-9063uhox	202	2	10	10	CD
cord-006139-9063uhox	202	3	was	be	VBD
cord-006139-9063uhox	202	4	also	also	RB
cord-006139-9063uhox	202	5	highly	highly	RB
cord-006139-9063uhox	202	6	active	active	JJ
cord-006139-9063uhox	202	7	against	against	IN
cord-006139-9063uhox	202	8	the	the	DT
cord-006139-9063uhox	202	9	K1	K1	NNP
cord-006139-9063uhox	202	10	,	,	,
cord-006139-9063uhox	202	11	Dd2	dd2	CD
cord-006139-9063uhox	202	12	,	,	,
cord-006139-9063uhox	202	13	W2	W2	NNP
cord-006139-9063uhox	202	14	and	and	CC
cord-006139-9063uhox	202	15	RSA11	RSA11	NNP
cord-006139-9063uhox	202	16	strains	strain	NNS
cord-006139-9063uhox	202	17	of	of	IN
cord-006139-9063uhox	202	18	chloroquine	chloroquine	NN
cord-006139-9063uhox	202	19	-	-	HYPH
cord-006139-9063uhox	202	20	resistant	resistant	JJ
cord-006139-9063uhox	202	21	parasites	parasite	NNS
cord-006139-9063uhox	202	22	,	,	,
cord-006139-9063uhox	202	23	with	with	IN
cord-006139-9063uhox	202	24	resistance	resistance	NN
cord-006139-9063uhox	202	25	indices	index	NNS
cord-006139-9063uhox	202	26	below	below	IN
cord-006139-9063uhox	202	27	2	2	CD
cord-006139-9063uhox	202	28	.	.	.
cord-006139-9063uhox	203	1	The	the	DT
cord-006139-9063uhox	203	2	three	three	CD
cord-006139-9063uhox	203	3	prototype	prototype	NN
cord-006139-9063uhox	203	4	compounds	compound	NNS
cord-006139-9063uhox	203	5	(	(	-LRB-
cord-006139-9063uhox	203	6	Compounds	Compounds	NNP
cord-006139-9063uhox	203	7	8	8	CD
cord-006139-9063uhox	203	8	,	,	,
cord-006139-9063uhox	203	9	9	9	CD
cord-006139-9063uhox	203	10	&	&	CC
cord-006139-9063uhox	203	11	10	10	CD
cord-006139-9063uhox	203	12	)	)	-RRB-
cord-006139-9063uhox	203	13	also	also	RB
cord-006139-9063uhox	203	14	had	have	VBD
cord-006139-9063uhox	203	15	good	good	JJ
cord-006139-9063uhox	203	16	in	in	IN
cord-006139-9063uhox	203	17	vivo	vivo	NN
cord-006139-9063uhox	203	18	antimalarial	antimalarial	JJ
cord-006139-9063uhox	203	19	activity	activity	NN
cord-006139-9063uhox	203	20	in	in	IN
cord-006139-9063uhox	203	21	the	the	DT
cord-006139-9063uhox	203	22	P.	P.	NNP
cord-006139-9063uhox	203	23	berghei	berghei	NN
cord-006139-9063uhox	203	24	mouse	mouse	NN
cord-006139-9063uhox	203	25	malaria	malaria	NN
cord-006139-9063uhox	203	26	model	model	NN
cord-006139-9063uhox	203	27	.	.	.
cord-006139-9063uhox	204	1	Two	two	CD
cord-006139-9063uhox	204	2	of	of	IN
cord-006139-9063uhox	204	3	the	the	DT
cord-006139-9063uhox	204	4	compounds	compound	NNS
cord-006139-9063uhox	204	5	were	be	VBD
cord-006139-9063uhox	204	6	curative	curative	JJ
cord-006139-9063uhox	204	7	when	when	WRB
cord-006139-9063uhox	204	8	using	use	VBG
cord-006139-9063uhox	204	9	three	three	CD
cord-006139-9063uhox	204	10	or	or	CC
cord-006139-9063uhox	204	11	four	four	CD
cord-006139-9063uhox	204	12	oral	oral	JJ
cord-006139-9063uhox	204	13	doses	dose	NNS
cord-006139-9063uhox	204	14	at	at	IN
cord-006139-9063uhox	204	15	100	100	CD
cord-006139-9063uhox	204	16	mg	mg	NNP
cord-006139-9063uhox	204	17	/	/	SYM
cord-006139-9063uhox	204	18	kg	kg	NNP
cord-006139-9063uhox	204	19	,	,	,
cord-006139-9063uhox	204	20	with	with	IN
cord-006139-9063uhox	204	21	parasites	parasite	NNS
cord-006139-9063uhox	204	22	being	be	VBG
cord-006139-9063uhox	204	23	undetectable	undetectable	JJ
cord-006139-9063uhox	204	24	30	30	CD
cord-006139-9063uhox	204	25	days	day	NNS
cord-006139-9063uhox	204	26	after	after	IN
cord-006139-9063uhox	204	27	treatment	treatment	NN
cord-006139-9063uhox	204	28	and	and	CC
cord-006139-9063uhox	204	29	with	with	IN
cord-006139-9063uhox	204	30	100	100	CD
cord-006139-9063uhox	204	31	%	%	NN
cord-006139-9063uhox	204	32	of	of	IN
cord-006139-9063uhox	204	33	the	the	DT
cord-006139-9063uhox	204	34	mice	mouse	NNS
cord-006139-9063uhox	204	35	surviving	survive	VBG
cord-006139-9063uhox	204	36	.	.	.
cord-006139-9063uhox	205	1	This	this	DT
cord-006139-9063uhox	205	2	series	series	NN
cord-006139-9063uhox	205	3	of	of	IN
cord-006139-9063uhox	205	4	compounds	compound	NNS
cord-006139-9063uhox	205	5	again	again	RB
cord-006139-9063uhox	205	6	illustrates	illustrate	VBZ
cord-006139-9063uhox	205	7	the	the	DT
cord-006139-9063uhox	205	8	potential	potential	NN
cord-006139-9063uhox	205	9	of	of	IN
cord-006139-9063uhox	205	10	the	the	DT
cord-006139-9063uhox	205	11	dual	dual	JJ
cord-006139-9063uhox	205	12	-	-	HYPH
cord-006139-9063uhox	205	13	function	function	NN
cord-006139-9063uhox	205	14	approach	approach	NN
cord-006139-9063uhox	205	15	to	to	IN
cord-006139-9063uhox	205	16	chloroquine	chloroquine	NN
cord-006139-9063uhox	205	17	resistance	resistance	NN
cord-006139-9063uhox	205	18	-	-	HYPH
cord-006139-9063uhox	205	19	reversing	reverse	VBG
cord-006139-9063uhox	205	20	antimalarially	antimalarially	NN
cord-006139-9063uhox	205	21	active	active	JJ
cord-006139-9063uhox	205	22	compounds	compound	NNS
cord-006139-9063uhox	205	23	.	.	.
cord-006139-9063uhox	206	1	In	in	IN
cord-006139-9063uhox	206	2	comparison	comparison	NN
cord-006139-9063uhox	206	3	with	with	IN
cord-006139-9063uhox	206	4	the	the	DT
cord-006139-9063uhox	206	5	initially	initially	RB
cord-006139-9063uhox	206	6	reported	report	VBN
cord-006139-9063uhox	206	7	reversed	reverse	VBN
cord-006139-9063uhox	206	8	chloroquine	chloroquine	NN
cord-006139-9063uhox	206	9	compounds	compound	NNS
cord-006139-9063uhox	206	10	,	,	,
cord-006139-9063uhox	206	11	the	the	DT
cord-006139-9063uhox	206	12	clogP	clogP	NNP
cord-006139-9063uhox	206	13	values	value	NNS
cord-006139-9063uhox	206	14	of	of	IN
cord-006139-9063uhox	206	15	this	this	DT
cord-006139-9063uhox	206	16	series	series	NN
cord-006139-9063uhox	206	17	were	be	VBD
cord-006139-9063uhox	206	18	considerably	considerably	RB
cord-006139-9063uhox	206	19	lower	low	JJR
cord-006139-9063uhox	206	20	(	(	-LRB-
cord-006139-9063uhox	206	21	5.42	5.42	CD
cord-006139-9063uhox	206	22	-	-	SYM
cord-006139-9063uhox	206	23	6.19	6.19	CD
cord-006139-9063uhox	206	24	)	)	-RRB-
cord-006139-9063uhox	206	25	and	and	CC
cord-006139-9063uhox	206	26	were	be	VBD
cord-006139-9063uhox	206	27	comparable	comparable	JJ
cord-006139-9063uhox	206	28	to	to	IN
cord-006139-9063uhox	206	29	chloroquine	chloroquine	NN
cord-006139-9063uhox	206	30	(	(	-LRB-
cord-006139-9063uhox	206	31	clogP	clogp	NN
cord-006139-9063uhox	206	32	=	=	SYM
cord-006139-9063uhox	206	33	5.1	5.1	CD
cord-006139-9063uhox	206	34	)	)	-RRB-
cord-006139-9063uhox	206	35	.	.	.
cord-006139-9063uhox	207	1	However	however	RB
cord-006139-9063uhox	207	2	,	,	,
cord-006139-9063uhox	207	3	less	less	RBR
cord-006139-9063uhox	207	4	hydrophobic	hydrophobic	JJ
cord-006139-9063uhox	207	5	compounds	compound	NNS
cord-006139-9063uhox	207	6	would	would	MD
cord-006139-9063uhox	207	7	still	still	RB
cord-006139-9063uhox	207	8	be	be	VB
cord-006139-9063uhox	207	9	more	more	RBR
cord-006139-9063uhox	207	10	desirable	desirable	JJ
cord-006139-9063uhox	207	11	and	and	CC
cord-006139-9063uhox	207	12	represent	represent	VBP
cord-006139-9063uhox	207	13	a	a	DT
cord-006139-9063uhox	207	14	priority	priority	NN
cord-006139-9063uhox	207	15	for	for	IN
cord-006139-9063uhox	207	16	any	any	DT
cord-006139-9063uhox	207	17	further	further	JJ
cord-006139-9063uhox	207	18	development	development	NN
cord-006139-9063uhox	207	19	of	of	IN
cord-006139-9063uhox	207	20	this	this	DT
cord-006139-9063uhox	207	21	series	series	NN
cord-006139-9063uhox	207	22	.	.	.
cord-006139-9063uhox	208	1	Several	several	JJ
cord-006139-9063uhox	208	2	dual	dual	JJ
cord-006139-9063uhox	208	3	-	-	HYPH
cord-006139-9063uhox	208	4	function	function	NN
cord-006139-9063uhox	208	5	quinolines	quinoline	NNS
cord-006139-9063uhox	208	6	designed	design	VBN
cord-006139-9063uhox	208	7	to	to	TO
cord-006139-9063uhox	208	8	exhibit	exhibit	VB
cord-006139-9063uhox	208	9	both	both	DT
cord-006139-9063uhox	208	10	antimalarial	antimalarial	JJ
cord-006139-9063uhox	208	11	and	and	CC
cord-006139-9063uhox	208	12	chloroquine	chloroquine	NN
cord-006139-9063uhox	208	13	resistance	resistance	NN
cord-006139-9063uhox	208	14	-	-	HYPH
cord-006139-9063uhox	208	15	reversal	reversal	NN
cord-006139-9063uhox	208	16	properties	property	NNS
cord-006139-9063uhox	208	17	have	have	VBP
cord-006139-9063uhox	208	18	been	be	VBN
cord-006139-9063uhox	208	19	made	make	VBN
cord-006139-9063uhox	208	20	that	that	DT
cord-006139-9063uhox	208	21	exhibit	exhibit	NN
cord-006139-9063uhox	208	22	good	good	JJ
cord-006139-9063uhox	208	23	in	in	IN
cord-006139-9063uhox	208	24	vivo	vivo	NN
cord-006139-9063uhox	208	25	activity	activity	NN
cord-006139-9063uhox	208	26	,	,	,
cord-006139-9063uhox	208	27	have	have	VBP
cord-006139-9063uhox	208	28	low	low	JJ
cord-006139-9063uhox	208	29	cytotoxicity	cytotoxicity	NN
cord-006139-9063uhox	208	30	and	and	CC
cord-006139-9063uhox	208	31	have	have	VBP
cord-006139-9063uhox	208	32	been	be	VBN
cord-006139-9063uhox	208	33	shown	show	VBN
cord-006139-9063uhox	208	34	by	by	IN
cord-006139-9063uhox	208	35	isobologram	isobologram	NNP
cord-006139-9063uhox	208	36	ana	ana	NNP
cord-006139-9063uhox	208	37	lysis	lysis	NN
cord-006139-9063uhox	208	38	to	to	TO
cord-006139-9063uhox	208	39	work	work	NN
cord-006139-9063uhox	208	40	synergistically	synergistically	RB
cord-006139-9063uhox	208	41	with	with	IN
cord-006139-9063uhox	208	42	chloroquine	chloroquine	NN
cord-006139-9063uhox	208	43	,	,	,
cord-006139-9063uhox	208	44	supporting	support	VBG
cord-006139-9063uhox	208	45	the	the	DT
cord-006139-9063uhox	208	46	hypothesis	hypothesis	NN
cord-006139-9063uhox	208	47	that	that	IN
cord-006139-9063uhox	208	48	they	-PRON-	PRP
cord-006139-9063uhox	208	49	do	do	VBP
cord-006139-9063uhox	208	50	indeed	indeed	RB
cord-006139-9063uhox	208	51	inhibit	inhibit	VB
cord-006139-9063uhox	208	52	chloroquine	chloroquine	NN
cord-006139-9063uhox	208	53	transport	transport	NN
cord-006139-9063uhox	208	54	by	by	IN
cord-006139-9063uhox	208	55	PfCRT	PfCRT	NNP
cord-006139-9063uhox	208	56	.	.	.
cord-006139-9063uhox	209	1	In	in	IN
cord-006139-9063uhox	209	2	addition	addition	NN
cord-006139-9063uhox	209	3	,	,	,
cord-006139-9063uhox	209	4	in	in	IN
cord-006139-9063uhox	209	5	at	at	RB
cord-006139-9063uhox	209	6	least	least	RBS
cord-006139-9063uhox	209	7	one	one	CD
cord-006139-9063uhox	209	8	group	group	NN
cord-006139-9063uhox	209	9	,	,	,
cord-006139-9063uhox	209	10	the	the	DT
cord-006139-9063uhox	209	11	dibemequines	dibemequine	NNS
cord-006139-9063uhox	209	12	,	,	,
cord-006139-9063uhox	209	13	inhibition	inhibition	NN
cord-006139-9063uhox	209	14	of	of	IN
cord-006139-9063uhox	209	15	the	the	DT
cord-006139-9063uhox	209	16	transport	transport	NN
cord-006139-9063uhox	209	17	of	of	IN
cord-006139-9063uhox	209	18	chloroquine	chloroquine	NN
cord-006139-9063uhox	209	19	by	by	IN
cord-006139-9063uhox	209	20	PfCRT	PfCRT	NNP
cord-006139-9063uhox	209	21	in	in	IN
cord-006139-9063uhox	209	22	the	the	DT
cord-006139-9063uhox	209	23	Xenopus	Xenopus	NNP
cord-006139-9063uhox	209	24	oocyte	oocyte	NN
cord-006139-9063uhox	209	25	has	have	VBZ
cord-006139-9063uhox	209	26	been	be	VBN
cord-006139-9063uhox	209	27	directly	directly	RB
cord-006139-9063uhox	209	28	demonstrated	demonstrate	VBN
cord-006139-9063uhox	209	29	.	.	.
cord-006139-9063uhox	210	1	In	in	IN
cord-006139-9063uhox	210	2	a	a	DT
cord-006139-9063uhox	210	3	review	review	NN
cord-006139-9063uhox	210	4	,	,	,
cord-006139-9063uhox	210	5	Peyton	Peyton	NNP
cord-006139-9063uhox	210	6	has	have	VBZ
cord-006139-9063uhox	210	7	also	also	RB
cord-006139-9063uhox	210	8	reported	report	VBN
cord-006139-9063uhox	210	9	that	that	IN
cord-006139-9063uhox	210	10	similar	similar	JJ
cord-006139-9063uhox	210	11	activity	activity	NN
cord-006139-9063uhox	210	12	has	have	VBZ
cord-006139-9063uhox	210	13	been	be	VBN
cord-006139-9063uhox	210	14	observed	observe	VBN
cord-006139-9063uhox	210	15	,	,	,
cord-006139-9063uhox	210	16	but	but	CC
cord-006139-9063uhox	210	17	not	not	RB
cord-006139-9063uhox	210	18	yet	yet	RB
cord-006139-9063uhox	210	19	published	publish	VBN
cord-006139-9063uhox	210	20	in	in	IN
cord-006139-9063uhox	210	21	the	the	DT
cord-006139-9063uhox	210	22	case	case	NN
cord-006139-9063uhox	210	23	of	of	IN
cord-006139-9063uhox	210	24	the	the	DT
cord-006139-9063uhox	210	25	reversed	reverse	VBN
cord-006139-9063uhox	210	26	chloroquines	chloroquine	NNS
cord-006139-9063uhox	210	27	[	[	-LRB-
cord-006139-9063uhox	210	28	82	82	CD
cord-006139-9063uhox	210	29	]	]	-RRB-
cord-006139-9063uhox	210	30	.	.	.
cord-006139-9063uhox	211	1	These	these	DT
cord-006139-9063uhox	211	2	compounds	compound	NNS
cord-006139-9063uhox	211	3	have	have	VBP
cord-006139-9063uhox	211	4	been	be	VBN
cord-006139-9063uhox	211	5	shown	show	VBN
cord-006139-9063uhox	211	6	to	to	TO
cord-006139-9063uhox	211	7	exhibit	exhibit	VB
cord-006139-9063uhox	211	8	strong	strong	JJ
cord-006139-9063uhox	211	9	in	in	IN
cord-006139-9063uhox	211	10	vitro	vitro	FW
cord-006139-9063uhox	211	11	antimalarial	antimalarial	JJ
cord-006139-9063uhox	211	12	activity	activity	NN
cord-006139-9063uhox	211	13	against	against	IN
cord-006139-9063uhox	211	14	a	a	DT
cord-006139-9063uhox	211	15	substantial	substantial	JJ
cord-006139-9063uhox	211	16	number	number	NN
cord-006139-9063uhox	211	17	of	of	IN
cord-006139-9063uhox	211	18	chloroquine	chloroquine	NN
cord-006139-9063uhox	211	19	-	-	HYPH
cord-006139-9063uhox	211	20	sensitive	sensitive	JJ
cord-006139-9063uhox	211	21	and	and	CC
cord-006139-9063uhox	211	22	-resistant	-resistant	JJ
cord-006139-9063uhox	211	23	parasite	parasite	NN
cord-006139-9063uhox	211	24	strains	strain	NNS
cord-006139-9063uhox	211	25	,	,	,
cord-006139-9063uhox	211	26	with	with	IN
cord-006139-9063uhox	211	27	no	no	DT
cord-006139-9063uhox	211	28	significant	significant	JJ
cord-006139-9063uhox	211	29	cross	cross	NN
cord-006139-9063uhox	211	30	-	-	NN
cord-006139-9063uhox	211	31	resistance	resistance	NN
cord-006139-9063uhox	211	32	with	with	IN
cord-006139-9063uhox	211	33	chloroquine	chloroquine	NN
cord-006139-9063uhox	211	34	.	.	.
cord-006139-9063uhox	212	1	Thus	thus	RB
cord-006139-9063uhox	212	2	,	,	,
cord-006139-9063uhox	212	3	in	in	IN
cord-006139-9063uhox	212	4	many	many	JJ
cord-006139-9063uhox	212	5	respects	respect	NNS
cord-006139-9063uhox	212	6	,	,	,
cord-006139-9063uhox	212	7	these	these	DT
cord-006139-9063uhox	212	8	compounds	compound	NNS
cord-006139-9063uhox	212	9	have	have	VBP
cord-006139-9063uhox	212	10	excellent	excellent	JJ
cord-006139-9063uhox	212	11	properties	property	NNS
cord-006139-9063uhox	212	12	for	for	IN
cord-006139-9063uhox	212	13	further	further	JJ
cord-006139-9063uhox	212	14	development	development	NN
cord-006139-9063uhox	212	15	.	.	.
cord-006139-9063uhox	213	1	However	however	RB
cord-006139-9063uhox	213	2	,	,	,
cord-006139-9063uhox	213	3	there	there	EX
cord-006139-9063uhox	213	4	are	be	VBP
cord-006139-9063uhox	213	5	some	some	DT
cord-006139-9063uhox	213	6	serious	serious	JJ
cord-006139-9063uhox	213	7	obstacles	obstacle	NNS
cord-006139-9063uhox	213	8	that	that	WDT
cord-006139-9063uhox	213	9	will	will	MD
cord-006139-9063uhox	213	10	need	need	VB
cord-006139-9063uhox	213	11	to	to	TO
cord-006139-9063uhox	213	12	be	be	VB
cord-006139-9063uhox	213	13	overcome	overcome	VBN
cord-006139-9063uhox	213	14	.	.	.
cord-006139-9063uhox	214	1	Weak	weak	JJ
cord-006139-9063uhox	214	2	base	base	NN
cord-006139-9063uhox	214	3	compounds	compound	NNS
cord-006139-9063uhox	214	4	,	,	,
cord-006139-9063uhox	214	5	particularly	particularly	RB
cord-006139-9063uhox	214	6	hydrophobic	hydrophobic	JJ
cord-006139-9063uhox	214	7	weak	weak	JJ
cord-006139-9063uhox	214	8	bases	basis	NNS
cord-006139-9063uhox	214	9	,	,	,
cord-006139-9063uhox	214	10	frequently	frequently	RB
cord-006139-9063uhox	214	11	exhibit	exhibit	VB
cord-006139-9063uhox	214	12	inhibitory	inhibitory	JJ
cord-006139-9063uhox	214	13	activity	activity	NN
cord-006139-9063uhox	214	14	against	against	IN
cord-006139-9063uhox	214	15	hERG	hERG	NNP
cord-006139-9063uhox	214	16	,	,	,
cord-006139-9063uhox	214	17	a	a	DT
cord-006139-9063uhox	214	18	potassium	potassium	NN
cord-006139-9063uhox	214	19	channel	channel	NN
cord-006139-9063uhox	214	20	found	find	VBN
cord-006139-9063uhox	214	21	in	in	IN
cord-006139-9063uhox	214	22	cardiac	cardiac	JJ
cord-006139-9063uhox	214	23	muscle	muscle	NN
cord-006139-9063uhox	214	24	.	.	.
cord-006139-9063uhox	215	1	This	this	DT
cord-006139-9063uhox	215	2	can	can	MD
cord-006139-9063uhox	215	3	lead	lead	VB
cord-006139-9063uhox	215	4	to	to	IN
cord-006139-9063uhox	215	5	prolonged	prolong	VBN
cord-006139-9063uhox	215	6	QT	qt	NN
cord-006139-9063uhox	215	7	intervals	interval	NNS
cord-006139-9063uhox	215	8	and	and	CC
cord-006139-9063uhox	215	9	potentially	potentially	RB
cord-006139-9063uhox	215	10	fatal	fatal	JJ
cord-006139-9063uhox	215	11	heart	heart	NN
cord-006139-9063uhox	215	12	arrhythmias	arrhythmias	RB
cord-006139-9063uhox	215	13	[	[	-LRB-
cord-006139-9063uhox	215	14	83	83	CD
cord-006139-9063uhox	215	15	]	]	-RRB-
cord-006139-9063uhox	215	16	.	.	.
cord-006139-9063uhox	216	1	Indeed	indeed	RB
cord-006139-9063uhox	216	2	,	,	,
cord-006139-9063uhox	216	3	in	in	IN
cord-006139-9063uhox	216	4	the	the	DT
cord-006139-9063uhox	216	5	case	case	NN
cord-006139-9063uhox	216	6	of	of	IN
cord-006139-9063uhox	216	7	at	at	RB
cord-006139-9063uhox	216	8	least	least	RBS
cord-006139-9063uhox	216	9	one	one	CD
cord-006139-9063uhox	216	10	antimalarial	antimalarial	JJ
cord-006139-9063uhox	216	11	drug	drug	NN
cord-006139-9063uhox	216	12	,	,	,
cord-006139-9063uhox	216	13	halofantrine	halofantrine	NNP
cord-006139-9063uhox	216	14	,	,	,
cord-006139-9063uhox	216	15	this	this	DT
cord-006139-9063uhox	216	16	problem	problem	NN
cord-006139-9063uhox	216	17	has	have	VBZ
cord-006139-9063uhox	216	18	actually	actually	RB
cord-006139-9063uhox	216	19	been	be	VBN
cord-006139-9063uhox	216	20	encountered	encounter	VBN
cord-006139-9063uhox	216	21	clinically	clinically	RB
cord-006139-9063uhox	216	22	[	[	-LRB-
cord-006139-9063uhox	216	23	84	84	CD
cord-006139-9063uhox	216	24	]	]	-RRB-
cord-006139-9063uhox	216	25	.	.	.
cord-006139-9063uhox	217	1	Unfortunately	unfortunately	RB
cord-006139-9063uhox	217	2	,	,	,
cord-006139-9063uhox	217	3	hERG	herg	NN
cord-006139-9063uhox	217	4	toxicity	toxicity	NN
cord-006139-9063uhox	217	5	is	be	VBZ
cord-006139-9063uhox	217	6	difficult	difficult	JJ
cord-006139-9063uhox	217	7	to	to	TO
cord-006139-9063uhox	217	8	predict	predict	VB
cord-006139-9063uhox	217	9	with	with	IN
cord-006139-9063uhox	217	10	certainty	certainty	NN
cord-006139-9063uhox	217	11	.	.	.
cord-006139-9063uhox	218	1	Nonetheless	nonetheless	RB
cord-006139-9063uhox	218	2	,	,	,
cord-006139-9063uhox	218	3	Gleeson	Gleeson	NNP
cord-006139-9063uhox	218	4	has	have	VBZ
cord-006139-9063uhox	218	5	carried	carry	VBN
cord-006139-9063uhox	218	6	out	out	RP
cord-006139-9063uhox	218	7	a	a	DT
cord-006139-9063uhox	218	8	principal	principal	JJ
cord-006139-9063uhox	218	9	components	component	NNS
cord-006139-9063uhox	218	10	ana	ana	NNP
cord-006139-9063uhox	218	11	lysis	lysis	NN
cord-006139-9063uhox	218	12	of	of	IN
cord-006139-9063uhox	218	13	approximately	approximately	RB
cord-006139-9063uhox	218	14	30,000	30,000	CD
cord-006139-9063uhox	218	15	compounds	compound	NNS
cord-006139-9063uhox	218	16	for	for	IN
cord-006139-9063uhox	218	17	which	which	WDT
cord-006139-9063uhox	218	18	absorption	absorption	NN
cord-006139-9063uhox	218	19	,	,	,
cord-006139-9063uhox	218	20	distribution	distribution	NN
cord-006139-9063uhox	218	21	,	,	,
cord-006139-9063uhox	218	22	metabolism	metabolism	NN
cord-006139-9063uhox	218	23	,	,	,
cord-006139-9063uhox	218	24	excretion	excretion	NN
cord-006139-9063uhox	218	25	and	and	CC
cord-006139-9063uhox	218	26	toxicity	toxicity	NN
cord-006139-9063uhox	218	27	data	datum	NNS
cord-006139-9063uhox	218	28	had	have	VBD
cord-006139-9063uhox	218	29	been	be	VBN
cord-006139-9063uhox	218	30	collected	collect	VBN
cord-006139-9063uhox	218	31	at	at	IN
cord-006139-9063uhox	218	32	Glaxo	Glaxo	NNP
cord-006139-9063uhox	218	33	-	-	HYPH
cord-006139-9063uhox	218	34	SmithKline	SmithKline	NNP
cord-006139-9063uhox	218	35	and	and	CC
cord-006139-9063uhox	218	36	found	find	VBD
cord-006139-9063uhox	218	37	that	that	IN
cord-006139-9063uhox	218	38	while	while	IN
cord-006139-9063uhox	218	39	there	there	EX
cord-006139-9063uhox	218	40	is	be	VBZ
cord-006139-9063uhox	218	41	a	a	DT
cord-006139-9063uhox	218	42	greater	great	JJR
cord-006139-9063uhox	218	43	potential	potential	NN
cord-006139-9063uhox	218	44	for	for	IN
cord-006139-9063uhox	218	45	hERG	herg	JJ
cord-006139-9063uhox	218	46	liability	liability	NN
cord-006139-9063uhox	218	47	in	in	IN
cord-006139-9063uhox	218	48	basic	basic	JJ
cord-006139-9063uhox	218	49	molecules	molecule	NNS
cord-006139-9063uhox	218	50	than	than	IN
cord-006139-9063uhox	218	51	in	in	IN
cord-006139-9063uhox	218	52	acidic	acidic	JJ
cord-006139-9063uhox	218	53	or	or	CC
cord-006139-9063uhox	218	54	neutral	neutral	JJ
cord-006139-9063uhox	218	55	ones	one	NNS
cord-006139-9063uhox	218	56	,	,	,
cord-006139-9063uhox	218	57	the	the	DT
cord-006139-9063uhox	218	58	liability	liability	NN
cord-006139-9063uhox	218	59	is	be	VBZ
cord-006139-9063uhox	218	60	generally	generally	RB
cord-006139-9063uhox	218	61	much	much	RB
cord-006139-9063uhox	218	62	reduced	reduce	VBN
cord-006139-9063uhox	218	63	if	if	IN
cord-006139-9063uhox	218	64	the	the	DT
cord-006139-9063uhox	218	65	compound	compound	NN
cord-006139-9063uhox	218	66	has	have	VBZ
cord-006139-9063uhox	218	67	a	a	DT
cord-006139-9063uhox	218	68	molecular	molecular	JJ
cord-006139-9063uhox	218	69	weight	weight	NN
cord-006139-9063uhox	218	70	below	below	IN
cord-006139-9063uhox	218	71	400	400	CD
cord-006139-9063uhox	218	72	and	and	CC
cord-006139-9063uhox	218	73	a	a	DT
cord-006139-9063uhox	218	74	calculated	calculate	VBN
cord-006139-9063uhox	218	75	cLogP	clogp	NN
cord-006139-9063uhox	219	1	below	below	IN
cord-006139-9063uhox	219	2	4	4	CD
cord-006139-9063uhox	219	3	[	[	-LRB-
cord-006139-9063uhox	219	4	85	85	CD
cord-006139-9063uhox	219	5	]	]	-RRB-
cord-006139-9063uhox	219	6	.	.	.
cord-006139-9063uhox	220	1	Indeed	indeed	RB
cord-006139-9063uhox	220	2	,	,	,
cord-006139-9063uhox	220	3	this	this	DT
cord-006139-9063uhox	220	4	also	also	RB
cord-006139-9063uhox	220	5	improves	improve	VBZ
cord-006139-9063uhox	220	6	druggability	druggability	NN
cord-006139-9063uhox	220	7	in	in	IN
cord-006139-9063uhox	220	8	a	a	DT
cord-006139-9063uhox	220	9	number	number	NN
cord-006139-9063uhox	220	10	of	of	IN
cord-006139-9063uhox	220	11	other	other	JJ
cord-006139-9063uhox	220	12	ways	way	NNS
cord-006139-9063uhox	220	13	.	.	.
cord-006139-9063uhox	221	1	For	for	IN
cord-006139-9063uhox	221	2	example	example	NN
cord-006139-9063uhox	221	3	,	,	,
cord-006139-9063uhox	221	4	it	-PRON-	PRP
cord-006139-9063uhox	221	5	improves	improve	VBZ
cord-006139-9063uhox	221	6	solubility	solubility	NN
cord-006139-9063uhox	221	7	,	,	,
cord-006139-9063uhox	221	8	permeability	permeability	NN
cord-006139-9063uhox	221	9	and	and	CC
cord-006139-9063uhox	221	10	volume	volume	NN
cord-006139-9063uhox	221	11	of	of	IN
cord-006139-9063uhox	221	12	distribution	distribution	NN
cord-006139-9063uhox	221	13	,	,	,
cord-006139-9063uhox	221	14	decreases	decrease	VBZ
cord-006139-9063uhox	221	15	protein	protein	NN
cord-006139-9063uhox	221	16	binding	binding	NN
cord-006139-9063uhox	221	17	and	and	CC
cord-006139-9063uhox	221	18	lowers	lower	VBZ
cord-006139-9063uhox	221	19	the	the	DT
cord-006139-9063uhox	221	20	potential	potential	NN
cord-006139-9063uhox	221	21	of	of	IN
cord-006139-9063uhox	221	22	the	the	DT
cord-006139-9063uhox	221	23	compound	compound	NN
cord-006139-9063uhox	221	24	to	to	TO
cord-006139-9063uhox	221	25	inhibit	inhibit	VB
cord-006139-9063uhox	221	26	cytochrome	cytochrome	NN
cord-006139-9063uhox	221	27	P450	p450	NN
cord-006139-9063uhox	221	28	.	.	.
cord-006139-9063uhox	222	1	As	as	IN
cord-006139-9063uhox	222	2	noted	note	VBN
cord-006139-9063uhox	222	3	above	above	RB
cord-006139-9063uhox	222	4	,	,	,
cord-006139-9063uhox	222	5	Peyton	Peyton	NNP
cord-006139-9063uhox	222	6	and	and	CC
cord-006139-9063uhox	222	7	coworkers	coworker	NNS
cord-006139-9063uhox	222	8	have	have	VBP
cord-006139-9063uhox	222	9	already	already	RB
cord-006139-9063uhox	222	10	produced	produce	VBN
cord-006139-9063uhox	222	11	reversed	reverse	VBN
cord-006139-9063uhox	222	12	chloroquines	chloroquine	NNS
cord-006139-9063uhox	222	13	with	with	IN
cord-006139-9063uhox	222	14	much	much	RB
cord-006139-9063uhox	222	15	improved	improve	VBN
cord-006139-9063uhox	222	16	cLogP	clogp	NN
cord-006139-9063uhox	222	17	values	value	NNS
cord-006139-9063uhox	222	18	[	[	-LRB-
cord-006139-9063uhox	222	19	77	77	CD
cord-006139-9063uhox	222	20	]	]	-RRB-
cord-006139-9063uhox	222	21	.	.	.
cord-006139-9063uhox	223	1	A	a	DT
cord-006139-9063uhox	223	2	dibemequine	dibemequine	NN
cord-006139-9063uhox	223	3	analog	analog	NN
cord-006139-9063uhox	223	4	has	have	VBZ
cord-006139-9063uhox	223	5	also	also	RB
cord-006139-9063uhox	223	6	been	be	VBN
cord-006139-9063uhox	223	7	produced	produce	VBN
cord-006139-9063uhox	223	8	with	with	IN
cord-006139-9063uhox	223	9	a	a	DT
cord-006139-9063uhox	223	10	cLogP	clogp	NN
cord-006139-9063uhox	223	11	well	well	UH
cord-006139-9063uhox	223	12	below	below	IN
cord-006139-9063uhox	223	13	4	4	CD
cord-006139-9063uhox	223	14	future	future	JJ
cord-006139-9063uhox	223	15	science	science	NN
cord-006139-9063uhox	223	16	group	group	NN
cord-006139-9063uhox	223	17	and	and	CC
cord-006139-9063uhox	223	18	a	a	DT
cord-006139-9063uhox	223	19	molecular	molecular	JJ
cord-006139-9063uhox	223	20	weight	weight	NN
cord-006139-9063uhox	223	21	below	below	IN
cord-006139-9063uhox	223	22	400	400	CD
cord-006139-9063uhox	224	1	[	[	-LRB-
cord-006139-9063uhox	224	2	Egan	Egan	NNP
cord-006139-9063uhox	224	3	TJ	TJ	NNP
cord-006139-9063uhox	224	4	et	et	NNP
cord-006139-9063uhox	224	5	al	al	NNP
cord-006139-9063uhox	224	6	.	.	NNP
cord-006139-9063uhox	224	7	,	,	,
cord-006139-9063uhox	224	8	Unpublished	Unpublished	NNP
cord-006139-9063uhox	224	9	Data	Data	NNP
cord-006139-9063uhox	224	10	]	]	-RRB-
cord-006139-9063uhox	224	11	.	.	.
cord-006139-9063uhox	225	1	While	while	IN
cord-006139-9063uhox	225	2	it	-PRON-	PRP
cord-006139-9063uhox	225	3	has	have	VBZ
cord-006139-9063uhox	225	4	not	not	RB
cord-006139-9063uhox	225	5	yet	yet	RB
cord-006139-9063uhox	225	6	been	be	VBN
cord-006139-9063uhox	225	7	demonstrated	demonstrate	VBN
cord-006139-9063uhox	225	8	that	that	IN
cord-006139-9063uhox	225	9	any	any	DT
cord-006139-9063uhox	225	10	of	of	IN
cord-006139-9063uhox	225	11	these	these	DT
cord-006139-9063uhox	225	12	compounds	compound	NNS
cord-006139-9063uhox	225	13	actually	actually	RB
cord-006139-9063uhox	225	14	have	have	VBP
cord-006139-9063uhox	225	15	reduced	reduce	VBN
cord-006139-9063uhox	225	16	hERG	herg	NN
cord-006139-9063uhox	225	17	liability	liability	NN
cord-006139-9063uhox	225	18	,	,	,
cord-006139-9063uhox	225	19	it	-PRON-	PRP
cord-006139-9063uhox	225	20	does	do	VBZ
cord-006139-9063uhox	225	21	at	at	IN
cord-006139-9063uhox	225	22	least	least	JJS
cord-006139-9063uhox	225	23	suggest	suggest	VB
cord-006139-9063uhox	225	24	that	that	IN
cord-006139-9063uhox	225	25	improvement	improvement	NN
cord-006139-9063uhox	225	26	is	be	VBZ
cord-006139-9063uhox	225	27	possible	possible	JJ
cord-006139-9063uhox	225	28	with	with	IN
cord-006139-9063uhox	225	29	this	this	DT
cord-006139-9063uhox	225	30	class	class	NN
cord-006139-9063uhox	225	31	of	of	IN
cord-006139-9063uhox	225	32	compound	compound	NN
cord-006139-9063uhox	225	33	.	.	.
cord-006139-9063uhox	226	1	A	a	DT
cord-006139-9063uhox	226	2	second	second	JJ
cord-006139-9063uhox	226	3	challenge	challenge	NN
cord-006139-9063uhox	226	4	relates	relate	VBZ
cord-006139-9063uhox	226	5	to	to	IN
cord-006139-9063uhox	226	6	the	the	DT
cord-006139-9063uhox	226	7	mechanism	mechanism	NN
cord-006139-9063uhox	226	8	of	of	IN
cord-006139-9063uhox	226	9	inhibition	inhibition	NN
cord-006139-9063uhox	226	10	in	in	IN
cord-006139-9063uhox	226	11	the	the	DT
cord-006139-9063uhox	226	12	mutant	mutant	JJ
cord-006139-9063uhox	226	13	PfCRT	PfCRT	NNP
cord-006139-9063uhox	226	14	.	.	.
cord-006139-9063uhox	227	1	It	-PRON-	PRP
cord-006139-9063uhox	227	2	is	be	VBZ
cord-006139-9063uhox	227	3	not	not	RB
cord-006139-9063uhox	227	4	currently	currently	RB
cord-006139-9063uhox	227	5	known	know	VBN
cord-006139-9063uhox	227	6	whether	whether	IN
cord-006139-9063uhox	227	7	these	these	DT
cord-006139-9063uhox	227	8	compounds	compound	NNS
cord-006139-9063uhox	227	9	inhibit	inhibit	VBP
cord-006139-9063uhox	227	10	chloroquine	chloroquine	NN
cord-006139-9063uhox	227	11	transport	transport	NN
cord-006139-9063uhox	227	12	competitively	competitively	RB
cord-006139-9063uhox	227	13	or	or	CC
cord-006139-9063uhox	227	14	noncompetitively	noncompetitively	RB
cord-006139-9063uhox	227	15	.	.	.
cord-006139-9063uhox	228	1	They	-PRON-	PRP
cord-006139-9063uhox	228	2	could	could	MD
cord-006139-9063uhox	228	3	bring	bring	VB
cord-006139-9063uhox	228	4	about	about	RP
cord-006139-9063uhox	228	5	inhibition	inhibition	NN
cord-006139-9063uhox	228	6	either	either	CC
cord-006139-9063uhox	228	7	by	by	IN
cord-006139-9063uhox	228	8	themselves	-PRON-	PRP
cord-006139-9063uhox	228	9	being	be	VBG
cord-006139-9063uhox	228	10	transported	transport	VBN
cord-006139-9063uhox	228	11	in	in	IN
cord-006139-9063uhox	228	12	preference	preference	NN
cord-006139-9063uhox	228	13	to	to	IN
cord-006139-9063uhox	228	14	chloroquine	chloroquine	NN
cord-006139-9063uhox	228	15	or	or	CC
cord-006139-9063uhox	228	16	by	by	IN
cord-006139-9063uhox	228	17	binding	bind	VBG
cord-006139-9063uhox	228	18	to	to	IN
cord-006139-9063uhox	228	19	PfCRT	PfCRT	NNP
cord-006139-9063uhox	228	20	and	and	CC
cord-006139-9063uhox	228	21	blocking	block	VBG
cord-006139-9063uhox	228	22	chloroquine	chloroquine	NN
cord-006139-9063uhox	228	23	transport	transport	NN
cord-006139-9063uhox	228	24	.	.	.
cord-006139-9063uhox	229	1	The	the	DT
cord-006139-9063uhox	229	2	latter	latter	NN
cord-006139-9063uhox	229	3	seems	seem	VBZ
cord-006139-9063uhox	229	4	more	more	RBR
cord-006139-9063uhox	229	5	likely	likely	JJ
cord-006139-9063uhox	229	6	,	,	,
cord-006139-9063uhox	229	7	since	since	IN
cord-006139-9063uhox	229	8	one	one	PRP
cord-006139-9063uhox	229	9	would	would	MD
cord-006139-9063uhox	229	10	expect	expect	VB
cord-006139-9063uhox	229	11	resistant	resistant	JJ
cord-006139-9063uhox	229	12	parasites	parasite	NNS
cord-006139-9063uhox	229	13	to	to	TO
cord-006139-9063uhox	229	14	be	be	VB
cord-006139-9063uhox	229	15	resistant	resistant	JJ
cord-006139-9063uhox	229	16	to	to	IN
cord-006139-9063uhox	229	17	the	the	DT
cord-006139-9063uhox	229	18	dualfunction	dualfunction	NN
cord-006139-9063uhox	229	19	molecule	molecule	NN
cord-006139-9063uhox	229	20	if	if	IN
cord-006139-9063uhox	229	21	it	-PRON-	PRP
cord-006139-9063uhox	229	22	were	be	VBD
cord-006139-9063uhox	229	23	transported	transport	VBN
cord-006139-9063uhox	229	24	out	out	IN
cord-006139-9063uhox	229	25	of	of	IN
cord-006139-9063uhox	229	26	the	the	DT
cord-006139-9063uhox	229	27	DV	DV	NNP
cord-006139-9063uhox	229	28	more	more	RBR
cord-006139-9063uhox	229	29	efficiently	efficiently	RB
cord-006139-9063uhox	229	30	than	than	IN
cord-006139-9063uhox	229	31	chloroquine	chloroquine	NN
cord-006139-9063uhox	229	32	.	.	.
cord-006139-9063uhox	230	1	If	if	IN
cord-006139-9063uhox	230	2	used	use	VBN
cord-006139-9063uhox	230	3	as	as	IN
cord-006139-9063uhox	230	4	monotherapies	monotherapies	NNP
cord-006139-9063uhox	230	5	,	,	,
cord-006139-9063uhox	230	6	these	these	DT
cord-006139-9063uhox	230	7	compounds	compound	NNS
cord-006139-9063uhox	230	8	might	may	MD
cord-006139-9063uhox	230	9	have	have	VB
cord-006139-9063uhox	230	10	an	an	DT
cord-006139-9063uhox	230	11	increased	increase	VBN
cord-006139-9063uhox	230	12	risk	risk	NN
cord-006139-9063uhox	230	13	of	of	IN
cord-006139-9063uhox	230	14	rapid	rapid	JJ
cord-006139-9063uhox	230	15	development	development	NN
cord-006139-9063uhox	230	16	of	of	IN
cord-006139-9063uhox	230	17	resistance	resistance	NN
cord-006139-9063uhox	230	18	because	because	IN
cord-006139-9063uhox	230	19	of	of	IN
cord-006139-9063uhox	230	20	their	-PRON-	PRP$
cord-006139-9063uhox	230	21	ability	ability	NN
cord-006139-9063uhox	230	22	to	to	TO
cord-006139-9063uhox	230	23	bind	bind	VB
cord-006139-9063uhox	230	24	to	to	IN
cord-006139-9063uhox	230	25	chloroquine	chloroquine	NN
cord-006139-9063uhox	230	26	-	-	HYPH
cord-006139-9063uhox	230	27	resistant	resistant	JJ
cord-006139-9063uhox	230	28	mutants	mutant	NNS
cord-006139-9063uhox	230	29	of	of	IN
cord-006139-9063uhox	230	30	PfCRT	PfCRT	NNP
cord-006139-9063uhox	230	31	.	.	.
cord-006139-9063uhox	231	1	It	-PRON-	PRP
cord-006139-9063uhox	231	2	is	be	VBZ
cord-006139-9063uhox	231	3	possible	possible	JJ
cord-006139-9063uhox	231	4	that	that	DT
cord-006139-9063uhox	231	5	point	point	NN
cord-006139-9063uhox	231	6	mutations	mutation	NNS
cord-006139-9063uhox	231	7	may	may	MD
cord-006139-9063uhox	231	8	then	then	RB
cord-006139-9063uhox	231	9	lead	lead	VB
cord-006139-9063uhox	231	10	from	from	IN
cord-006139-9063uhox	231	11	binding	bind	VBG
cord-006139-9063uhox	231	12	to	to	IN
cord-006139-9063uhox	231	13	transport	transport	NN
cord-006139-9063uhox	231	14	.	.	.
cord-006139-9063uhox	232	1	This	this	DT
cord-006139-9063uhox	232	2	potential	potential	JJ
cord-006139-9063uhox	232	3	problem	problem	NN
cord-006139-9063uhox	232	4	would	would	MD
cord-006139-9063uhox	232	5	likely	likely	RB
cord-006139-9063uhox	232	6	be	be	VB
cord-006139-9063uhox	232	7	lessened	lessen	VBN
cord-006139-9063uhox	232	8	by	by	IN
cord-006139-9063uhox	232	9	use	use	NN
cord-006139-9063uhox	232	10	of	of	IN
cord-006139-9063uhox	232	11	combination	combination	NN
cord-006139-9063uhox	232	12	therapy	therapy	NN
cord-006139-9063uhox	232	13	.	.	.
cord-006139-9063uhox	233	1	In	in	IN
cord-006139-9063uhox	233	2	addition	addition	NN
cord-006139-9063uhox	233	3	,	,	,
cord-006139-9063uhox	233	4	with	with	IN
cord-006139-9063uhox	233	5	the	the	DT
cord-006139-9063uhox	233	6	exception	exception	NN
cord-006139-9063uhox	233	7	of	of	IN
cord-006139-9063uhox	233	8	one	one	CD
cord-006139-9063uhox	233	9	group	group	NN
cord-006139-9063uhox	233	10	of	of	IN
cord-006139-9063uhox	233	11	reversed	reversed	JJ
cord-006139-9063uhox	233	12	chloroquines	chloroquine	NNS
cord-006139-9063uhox	233	13	,	,	,
cord-006139-9063uhox	233	14	the	the	DT
cord-006139-9063uhox	233	15	activities	activity	NNS
cord-006139-9063uhox	233	16	of	of	IN
cord-006139-9063uhox	233	17	these	these	DT
cord-006139-9063uhox	233	18	compounds	compound	NNS
cord-006139-9063uhox	233	19	against	against	IN
cord-006139-9063uhox	233	20	South	south	JJ
cord-006139-9063uhox	233	21	American	american	JJ
cord-006139-9063uhox	233	22	strains	strain	NNS
cord-006139-9063uhox	233	23	such	such	JJ
cord-006139-9063uhox	233	24	as	as	IN
cord-006139-9063uhox	233	25	7G8	7g8	CD
cord-006139-9063uhox	233	26	,	,	,
cord-006139-9063uhox	233	27	with	with	IN
cord-006139-9063uhox	233	28	reduced	reduce	VBN
cord-006139-9063uhox	233	29	sensitivity	sensitivity	NN
cord-006139-9063uhox	233	30	to	to	IN
cord-006139-9063uhox	233	31	verapamil	verapamil	NN
cord-006139-9063uhox	233	32	resistance	resistance	NN
cord-006139-9063uhox	233	33	reversal	reversal	NN
cord-006139-9063uhox	233	34	,	,	,
cord-006139-9063uhox	233	35	have	have	VBP
cord-006139-9063uhox	233	36	not	not	RB
cord-006139-9063uhox	233	37	been	be	VBN
cord-006139-9063uhox	233	38	n	n	XX
cord-006139-9063uhox	234	1	Malaria	Malaria	NNP
cord-006139-9063uhox	234	2	is	be	VBZ
cord-006139-9063uhox	234	3	responsible	responsible	JJ
cord-006139-9063uhox	234	4	for	for	IN
cord-006139-9063uhox	234	5	the	the	DT
cord-006139-9063uhox	234	6	deaths	death	NNS
cord-006139-9063uhox	234	7	of	of	IN
cord-006139-9063uhox	234	8	over	over	IN
cord-006139-9063uhox	234	9	600,000	600,000	CD
cord-006139-9063uhox	234	10	people	people	NNS
cord-006139-9063uhox	234	11	a	a	DT
cord-006139-9063uhox	234	12	year	year	NN
cord-006139-9063uhox	234	13	,	,	,
cord-006139-9063uhox	234	14	approximately	approximately	RB
cord-006139-9063uhox	234	15	90	90	CD
cord-006139-9063uhox	234	16	%	%	NN
cord-006139-9063uhox	234	17	of	of	IN
cord-006139-9063uhox	234	18	them	-PRON-	PRP
cord-006139-9063uhox	234	19	in	in	IN
cord-006139-9063uhox	234	20	Africa	Africa	NNP
cord-006139-9063uhox	234	21	.	.	.
cord-006139-9063uhox	235	1	n	n	LS
cord-006139-9063uhox	235	2	Resistance	Resistance	NNP
cord-006139-9063uhox	235	3	to	to	IN
cord-006139-9063uhox	235	4	existing	exist	VBG
cord-006139-9063uhox	235	5	drugs	drug	NNS
cord-006139-9063uhox	235	6	and	and	CC
cord-006139-9063uhox	235	7	evidence	evidence	NN
cord-006139-9063uhox	235	8	of	of	IN
cord-006139-9063uhox	235	9	delayed	delay	VBN
cord-006139-9063uhox	235	10	parasite	parasite	NN
cord-006139-9063uhox	235	11	clearance	clearance	NN
cord-006139-9063uhox	235	12	with	with	IN
cord-006139-9063uhox	235	13	artemisinins	artemisinin	NNS
cord-006139-9063uhox	235	14	,	,	,
cord-006139-9063uhox	235	15	which	which	WDT
cord-006139-9063uhox	235	16	is	be	VBZ
cord-006139-9063uhox	235	17	currently	currently	RB
cord-006139-9063uhox	235	18	the	the	DT
cord-006139-9063uhox	235	19	most	most	RBS
cord-006139-9063uhox	235	20	important	important	JJ
cord-006139-9063uhox	235	21	class	class	NN
cord-006139-9063uhox	235	22	of	of	IN
cord-006139-9063uhox	235	23	antimalarial	antimalarial	JJ
cord-006139-9063uhox	235	24	,	,	,
cord-006139-9063uhox	235	25	is	be	VBZ
cord-006139-9063uhox	235	26	a	a	DT
cord-006139-9063uhox	235	27	major	major	JJ
cord-006139-9063uhox	235	28	cause	cause	NN
cord-006139-9063uhox	235	29	for	for	IN
cord-006139-9063uhox	235	30	concern	concern	NN
cord-006139-9063uhox	235	31	.	.	.
cord-006139-9063uhox	236	1	n	n	NNP
cord-006139-9063uhox	236	2	Continued	continued	JJ
cord-006139-9063uhox	236	3	discovery	discovery	NN
cord-006139-9063uhox	236	4	of	of	IN
cord-006139-9063uhox	236	5	new	new	JJ
cord-006139-9063uhox	236	6	antimalarials	antimalarial	NNS
cord-006139-9063uhox	236	7	is	be	VBZ
cord-006139-9063uhox	236	8	an	an	DT
cord-006139-9063uhox	236	9	important	important	JJ
cord-006139-9063uhox	236	10	strategy	strategy	NN
cord-006139-9063uhox	236	11	.	.	.
cord-006139-9063uhox	237	1	n	n	LS
cord-006139-9063uhox	237	2	Historically	historically	RB
cord-006139-9063uhox	237	3	,	,	,
cord-006139-9063uhox	237	4	the	the	DT
cord-006139-9063uhox	237	5	quinolines	quinoline	NNS
cord-006139-9063uhox	237	6	have	have	VBP
cord-006139-9063uhox	237	7	been	be	VBN
cord-006139-9063uhox	237	8	one	one	CD
cord-006139-9063uhox	237	9	of	of	IN
cord-006139-9063uhox	237	10	the	the	DT
cord-006139-9063uhox	237	11	most	most	RBS
cord-006139-9063uhox	237	12	important	important	JJ
cord-006139-9063uhox	237	13	classes	class	NNS
cord-006139-9063uhox	237	14	of	of	IN
cord-006139-9063uhox	237	15	antimalarial	antimalarial	JJ
cord-006139-9063uhox	237	16	drug	drug	NN
cord-006139-9063uhox	237	17	.	.	.
cord-006139-9063uhox	238	1	n	n	LS
cord-006139-9063uhox	238	2	They	-PRON-	PRP
cord-006139-9063uhox	238	3	are	be	VBP
cord-006139-9063uhox	238	4	known	know	VBN
cord-006139-9063uhox	238	5	to	to	TO
cord-006139-9063uhox	238	6	interact	interact	VB
cord-006139-9063uhox	238	7	with	with	IN
cord-006139-9063uhox	238	8	Fe(III)heme	fe(iii)heme	ADD
cord-006139-9063uhox	238	9	.	.	.
cord-006139-9063uhox	239	1	Recently	recently	RB
cord-006139-9063uhox	239	2	,	,	,
cord-006139-9063uhox	239	3	crystal	crystal	NN
cord-006139-9063uhox	239	4	structures	structure	NNS
cord-006139-9063uhox	239	5	of	of	IN
cord-006139-9063uhox	239	6	the	the	DT
cord-006139-9063uhox	239	7	Fe(III)heme	Fe(III)heme	NNP
cord-006139-9063uhox	239	8	complexes	complex	NNS
cord-006139-9063uhox	239	9	of	of	IN
cord-006139-9063uhox	239	10	the	the	DT
cord-006139-9063uhox	239	11	quinoline	quinoline	NNP
cord-006139-9063uhox	239	12	methanols	methanol	NNS
cord-006139-9063uhox	239	13	,	,	,
cord-006139-9063uhox	239	14	quinine	quinine	NN
cord-006139-9063uhox	239	15	and	and	CC
cord-006139-9063uhox	239	16	quinidine	quinidine	NN
cord-006139-9063uhox	239	17	and	and	CC
cord-006139-9063uhox	239	18	the	the	DT
cord-006139-9063uhox	239	19	related	related	JJ
cord-006139-9063uhox	239	20	aryl	aryl	NN
cord-006139-9063uhox	239	21	methanol	methanol	NN
cord-006139-9063uhox	239	22	,	,	,
cord-006139-9063uhox	239	23	halofantrine	halofantrine	NNP
cord-006139-9063uhox	239	24	,	,	,
cord-006139-9063uhox	239	25	have	have	VBP
cord-006139-9063uhox	239	26	been	be	VBN
cord-006139-9063uhox	239	27	reported	report	VBN
cord-006139-9063uhox	239	28	.	.	.
cord-006139-9063uhox	240	1	n	n	CC
cord-006139-9063uhox	240	2	Chloroquine	Chloroquine	NNP
cord-006139-9063uhox	240	3	is	be	VBZ
cord-006139-9063uhox	240	4	believed	believe	VBN
cord-006139-9063uhox	240	5	to	to	TO
cord-006139-9063uhox	240	6	act	act	VB
cord-006139-9063uhox	240	7	by	by	IN
cord-006139-9063uhox	240	8	inhibiting	inhibit	VBG
cord-006139-9063uhox	240	9	the	the	DT
cord-006139-9063uhox	240	10	incorporation	incorporation	NN
cord-006139-9063uhox	240	11	of	of	IN
cord-006139-9063uhox	240	12	Fe(III)heme	fe(iii)heme	CD
cord-006139-9063uhox	240	13	,	,	,
cord-006139-9063uhox	240	14	released	release	VBN
cord-006139-9063uhox	240	15	when	when	WRB
cord-006139-9063uhox	240	16	the	the	DT
cord-006139-9063uhox	240	17	parasite	parasite	NN
cord-006139-9063uhox	240	18	digests	digest	VBZ
cord-006139-9063uhox	240	19	host	host	NN
cord-006139-9063uhox	240	20	hemoglobin	hemoglobin	NN
cord-006139-9063uhox	240	21	,	,	,
cord-006139-9063uhox	240	22	into	into	IN
cord-006139-9063uhox	240	23	hemozoin	hemozoin	NNP
cord-006139-9063uhox	240	24	,	,	,
cord-006139-9063uhox	240	25	an	an	DT
cord-006139-9063uhox	240	26	insoluble	insoluble	JJ
cord-006139-9063uhox	240	27	crystalline	crystalline	JJ
cord-006139-9063uhox	240	28	form	form	NN
cord-006139-9063uhox	240	29	of	of	IN
cord-006139-9063uhox	240	30	Fe(III)heme	fe(iii)heme	CD
cord-006139-9063uhox	240	31	.	.	.
cord-006139-9063uhox	241	1	n	n	NNP
cord-006139-9063uhox	242	1	Recent	recent	JJ
cord-006139-9063uhox	242	2	work	work	NN
cord-006139-9063uhox	242	3	has	have	VBZ
cord-006139-9063uhox	242	4	shown	show	VBN
cord-006139-9063uhox	242	5	that	that	IN
cord-006139-9063uhox	242	6	chloroquine	chloroquine	NN
cord-006139-9063uhox	242	7	causes	cause	VBZ
cord-006139-9063uhox	242	8	a	a	DT
cord-006139-9063uhox	242	9	dose	dose	NN
cord-006139-9063uhox	242	10	-	-	HYPH
cord-006139-9063uhox	242	11	dependent	dependent	JJ
cord-006139-9063uhox	242	12	increase	increase	NN
cord-006139-9063uhox	242	13	in	in	IN
cord-006139-9063uhox	242	14	free	free	JJ
cord-006139-9063uhox	242	15	Fe(III)heme	Fe(III)heme	NNS
cord-006139-9063uhox	242	16	and	and	CC
cord-006139-9063uhox	242	17	a	a	DT
cord-006139-9063uhox	242	18	decrease	decrease	NN
cord-006139-9063uhox	242	19	in	in	IN
cord-006139-9063uhox	242	20	hemozoin	hemozoin	NNP
cord-006139-9063uhox	242	21	in	in	IN
cord-006139-9063uhox	242	22	treated	treat	VBN
cord-006139-9063uhox	242	23	parasites	parasite	NNS
cord-006139-9063uhox	242	24	that	that	WDT
cord-006139-9063uhox	242	25	is	be	VBZ
cord-006139-9063uhox	242	26	correlated	correlate	VBN
cord-006139-9063uhox	242	27	with	with	IN
cord-006139-9063uhox	242	28	parasite	parasite	JJ
cord-006139-9063uhox	242	29	survival	survival	NN
cord-006139-9063uhox	242	30	.	.	.
cord-006139-9063uhox	243	1	In	in	IN
cord-006139-9063uhox	243	2	addition	addition	NN
cord-006139-9063uhox	243	3	,	,	,
cord-006139-9063uhox	243	4	chloroquine	chloroquine	NN
cord-006139-9063uhox	243	5	treatment	treatment	NN
cord-006139-9063uhox	243	6	has	have	VBZ
cord-006139-9063uhox	243	7	been	be	VBN
cord-006139-9063uhox	243	8	shown	show	VBN
cord-006139-9063uhox	243	9	to	to	TO
cord-006139-9063uhox	243	10	redistribute	redistribute	VB
cord-006139-9063uhox	243	11	heme	heme	NN
cord-006139-9063uhox	243	12	into	into	IN
cord-006139-9063uhox	243	13	the	the	DT
cord-006139-9063uhox	243	14	parasite	parasite	NN
cord-006139-9063uhox	243	15	cytoplasm	cytoplasm	NN
cord-006139-9063uhox	243	16	and	and	CC
cord-006139-9063uhox	243	17	disrupt	disrupt	VB
cord-006139-9063uhox	243	18	the	the	DT
cord-006139-9063uhox	243	19	hemozoin	hemozoin	NNP
cord-006139-9063uhox	243	20	crystal	crystal	NN
cord-006139-9063uhox	243	21	lattice	lattice	NN
cord-006139-9063uhox	243	22	.	.	.
cord-006139-9063uhox	244	1	n	n	NNP
cord-006139-9063uhox	244	2	Chloroquine	Chloroquine	NNP
cord-006139-9063uhox	244	3	resistance	resistance	NN
cord-006139-9063uhox	244	4	is	be	VBZ
cord-006139-9063uhox	244	5	now	now	RB
cord-006139-9063uhox	244	6	widespread	widespread	JJ
cord-006139-9063uhox	244	7	.	.	.
cord-006139-9063uhox	245	1	n	n	NNP
cord-006139-9063uhox	246	1	Such	such	JJ
cord-006139-9063uhox	246	2	resistance	resistance	NN
cord-006139-9063uhox	246	3	is	be	VBZ
cord-006139-9063uhox	246	4	largely	largely	RB
cord-006139-9063uhox	246	5	attributable	attributable	JJ
cord-006139-9063uhox	246	6	to	to	IN
cord-006139-9063uhox	246	7	mutations	mutation	NNS
cord-006139-9063uhox	246	8	in	in	IN
cord-006139-9063uhox	246	9	a	a	DT
cord-006139-9063uhox	246	10	protein	protein	NN
cord-006139-9063uhox	246	11	,	,	,
cord-006139-9063uhox	246	12	PfCRT	PfCRT	NNP
cord-006139-9063uhox	246	13	,	,	,
cord-006139-9063uhox	246	14	found	find	VBN
cord-006139-9063uhox	246	15	in	in	IN
cord-006139-9063uhox	246	16	the	the	DT
cord-006139-9063uhox	246	17	membrane	membrane	NN
cord-006139-9063uhox	246	18	of	of	IN
cord-006139-9063uhox	246	19	the	the	DT
cord-006139-9063uhox	246	20	digestive	digestive	JJ
cord-006139-9063uhox	246	21	vacuole	vacuole	NN
cord-006139-9063uhox	246	22	where	where	WRB
cord-006139-9063uhox	246	23	hemoglobin	hemoglobin	NN
cord-006139-9063uhox	246	24	digestion	digestion	NN
cord-006139-9063uhox	246	25	takes	take	VBZ
cord-006139-9063uhox	246	26	place	place	NN
cord-006139-9063uhox	246	27	.	.	.
cord-006139-9063uhox	247	1	n	n	LS
cord-006139-9063uhox	247	2	A	a	DT
cord-006139-9063uhox	247	3	mutant	mutant	JJ
cord-006139-9063uhox	247	4	form	form	NN
cord-006139-9063uhox	247	5	of	of	IN
cord-006139-9063uhox	247	6	PfCRT	PfCRT	NNP
cord-006139-9063uhox	247	7	from	from	IN
cord-006139-9063uhox	247	8	chloroquine	chloroquine	NN
cord-006139-9063uhox	247	9	-	-	HYPH
cord-006139-9063uhox	247	10	resistant	resistant	JJ
cord-006139-9063uhox	247	11	parasites	parasite	NNS
cord-006139-9063uhox	247	12	has	have	VBZ
cord-006139-9063uhox	247	13	been	be	VBN
cord-006139-9063uhox	247	14	shown	show	VBN
cord-006139-9063uhox	247	15	to	to	TO
cord-006139-9063uhox	247	16	directly	directly	RB
cord-006139-9063uhox	247	17	transport	transport	VB
cord-006139-9063uhox	247	18	chloroquine	chloroquine	NN
cord-006139-9063uhox	247	19	in	in	IN
cord-006139-9063uhox	247	20	Xenopus	Xenopus	NNP
cord-006139-9063uhox	247	21	laevis	laevi	NNS
cord-006139-9063uhox	247	22	oocytes	oocyte	NNS
cord-006139-9063uhox	247	23	.	.	.
cord-006139-9063uhox	248	1	n	n	CC
cord-006139-9063uhox	248	2	A	a	DT
cord-006139-9063uhox	248	3	variety	variety	NN
cord-006139-9063uhox	248	4	of	of	IN
cord-006139-9063uhox	248	5	compounds	compound	NNS
cord-006139-9063uhox	248	6	have	have	VBP
cord-006139-9063uhox	248	7	been	be	VBN
cord-006139-9063uhox	248	8	discovered	discover	VBN
cord-006139-9063uhox	248	9	that	that	IN
cord-006139-9063uhox	248	10	chemosensitize	chemosensitize	NNP
cord-006139-9063uhox	248	11	chloroquine	chloroquine	NN
cord-006139-9063uhox	248	12	-	-	HYPH
cord-006139-9063uhox	248	13	resistant	resistant	JJ
cord-006139-9063uhox	248	14	parasites	parasite	NNS
cord-006139-9063uhox	248	15	to	to	IN
cord-006139-9063uhox	248	16	chloroquine	chloroquine	NN
cord-006139-9063uhox	248	17	.	.	.
cord-006139-9063uhox	249	1	These	these	DT
cord-006139-9063uhox	249	2	are	be	VBP
cord-006139-9063uhox	249	3	often	often	RB
cord-006139-9063uhox	249	4	referred	refer	VBN
cord-006139-9063uhox	249	5	to	to	IN
cord-006139-9063uhox	249	6	as	as	IN
cord-006139-9063uhox	249	7	resistance	resistance	NN
cord-006139-9063uhox	249	8	reversers	reverser	NNS
cord-006139-9063uhox	249	9	.	.	.
cord-006139-9063uhox	250	1	n	n	NNP
cord-006139-9063uhox	250	2	Combination	Combination	NNP
cord-006139-9063uhox	250	3	of	of	IN
cord-006139-9063uhox	250	4	a	a	DT
cord-006139-9063uhox	250	5	4-amino-7-chloroquinoline	4-amino-7-chloroquinoline	CD
cord-006139-9063uhox	250	6	with	with	IN
cord-006139-9063uhox	250	7	an	an	DT
cord-006139-9063uhox	250	8	imipramine	imipramine	NN
cord-006139-9063uhox	250	9	-	-	HYPH
cord-006139-9063uhox	250	10	like	like	JJ
cord-006139-9063uhox	250	11	group	group	NN
cord-006139-9063uhox	250	12	led	lead	VBD
cord-006139-9063uhox	250	13	to	to	IN
cord-006139-9063uhox	250	14	the	the	DT
cord-006139-9063uhox	250	15	first	first	JJ
cord-006139-9063uhox	250	16	example	example	NN
cord-006139-9063uhox	250	17	of	of	IN
cord-006139-9063uhox	250	18	a	a	DT
cord-006139-9063uhox	250	19	putative	putative	JJ
cord-006139-9063uhox	250	20	dual	dual	JJ
cord-006139-9063uhox	250	21	-	-	HYPH
cord-006139-9063uhox	250	22	function	function	NN
cord-006139-9063uhox	250	23	'	'	''
cord-006139-9063uhox	250	24	reversed	reverse	VBN
cord-006139-9063uhox	250	25	chloroquine	chloroquine	NN
cord-006139-9063uhox	250	26	'	'	''
cord-006139-9063uhox	250	27	.	.	.
cord-006139-9063uhox	251	1	n	n	LS
cord-006139-9063uhox	251	2	Subsequent	subsequent	JJ
cord-006139-9063uhox	251	3	work	work	NN
cord-006139-9063uhox	251	4	has	have	VBZ
cord-006139-9063uhox	251	5	led	lead	VBN
cord-006139-9063uhox	251	6	to	to	IN
cord-006139-9063uhox	251	7	improvements	improvement	NNS
cord-006139-9063uhox	251	8	in	in	IN
cord-006139-9063uhox	251	9	water	water	NN
cord-006139-9063uhox	251	10	solubility	solubility	NN
cord-006139-9063uhox	251	11	and	and	CC
cord-006139-9063uhox	251	12	oral	oral	JJ
cord-006139-9063uhox	251	13	bioavailability	bioavailability	NN
cord-006139-9063uhox	251	14	of	of	IN
cord-006139-9063uhox	251	15	this	this	DT
cord-006139-9063uhox	251	16	class	class	NN
cord-006139-9063uhox	251	17	of	of	IN
cord-006139-9063uhox	251	18	compound	compound	NN
cord-006139-9063uhox	251	19	.	.	.
cord-006139-9063uhox	252	1	n	n	LS
cord-006139-9063uhox	252	2	Reversed	reversed	JJ
cord-006139-9063uhox	252	3	chloroquines	chloroquine	NNS
cord-006139-9063uhox	252	4	have	have	VBP
cord-006139-9063uhox	252	5	been	be	VBN
cord-006139-9063uhox	252	6	shown	show	VBN
cord-006139-9063uhox	252	7	to	to	TO
cord-006139-9063uhox	252	8	interact	interact	VB
cord-006139-9063uhox	252	9	with	with	IN
cord-006139-9063uhox	252	10	Fe(III)heme	Fe(III)heme	NNP
cord-006139-9063uhox	252	11	and	and	CC
cord-006139-9063uhox	252	12	inhibit	inhibit	VB
cord-006139-9063uhox	252	13	parasite	parasite	NN
cord-006139-9063uhox	252	14	hemozoin	hemozoin	NNP
cord-006139-9063uhox	252	15	formation	formation	NN
cord-006139-9063uhox	252	16	.	.	.
cord-006139-9063uhox	253	1	n	n	DT
cord-006139-9063uhox	253	2	New	new	JJ
cord-006139-9063uhox	253	3	reversed	reversed	JJ
cord-006139-9063uhox	253	4	chloroquine	chloroquine	NN
cord-006139-9063uhox	253	5	-	-	HYPH
cord-006139-9063uhox	253	6	like	like	JJ
cord-006139-9063uhox	253	7	molecules	molecule	NNS
cord-006139-9063uhox	253	8	have	have	VBP
cord-006139-9063uhox	253	9	been	be	VBN
cord-006139-9063uhox	253	10	discovered	discover	VBN
cord-006139-9063uhox	253	11	,	,	,
cord-006139-9063uhox	253	12	including	include	VBG
cord-006139-9063uhox	253	13	dual	dual	JJ
cord-006139-9063uhox	253	14	-	-	HYPH
cord-006139-9063uhox	253	15	function	function	NN
cord-006139-9063uhox	253	16	acridones	acridone	NNS
cord-006139-9063uhox	253	17	,	,	,
cord-006139-9063uhox	253	18	reversed	reverse	VBD
cord-006139-9063uhox	253	19	chloroquines	chloroquine	NNS
cord-006139-9063uhox	253	20	containing	contain	VBG
cord-006139-9063uhox	253	21	a	a	DT
cord-006139-9063uhox	253	22	dihydropyrimidinone	dihydropyrimidinone	NNP
cord-006139-9063uhox	253	23	group	group	NN
cord-006139-9063uhox	253	24	and	and	CC
cord-006139-9063uhox	253	25	dibemequines	dibemequines	NNP
cord-006139-9063uhox	253	26	.	.	.
cord-006139-9063uhox	254	1	n	n	LS
cord-006139-9063uhox	254	2	Dibemequines	Dibemequines	NNP
cord-006139-9063uhox	254	3	inhibit	inhibit	VBP
cord-006139-9063uhox	254	4	b	b	NN
cord-006139-9063uhox	254	5	-	-	HYPH
cord-006139-9063uhox	254	6	hematin	hematin	NN
cord-006139-9063uhox	254	7	formation	formation	NN
cord-006139-9063uhox	254	8	and	and	CC
cord-006139-9063uhox	254	9	have	have	VBP
cord-006139-9063uhox	254	10	been	be	VBN
cord-006139-9063uhox	254	11	shown	show	VBN
cord-006139-9063uhox	254	12	to	to	TO
cord-006139-9063uhox	254	13	directly	directly	RB
cord-006139-9063uhox	254	14	inhibit	inhibit	VB
cord-006139-9063uhox	254	15	chloroquine	chloroquine	NN
cord-006139-9063uhox	254	16	transport	transport	NN
cord-006139-9063uhox	254	17	by	by	IN
cord-006139-9063uhox	254	18	PfCRT	PfCRT	NNP
cord-006139-9063uhox	254	19	.	.	.
cord-006139-9063uhox	255	1	n	n	NNP
cord-006139-9063uhox	256	1	The	the	DT
cord-006139-9063uhox	256	2	dibemequines	dibemequine	NNS
cord-006139-9063uhox	256	3	have	have	VBP
cord-006139-9063uhox	256	4	been	be	VBN
cord-006139-9063uhox	256	5	shown	show	VBN
cord-006139-9063uhox	256	6	to	to	TO
cord-006139-9063uhox	256	7	maintain	maintain	VB
cord-006139-9063uhox	256	8	activity	activity	NN
cord-006139-9063uhox	256	9	against	against	IN
cord-006139-9063uhox	256	10	a	a	DT
cord-006139-9063uhox	256	11	range	range	NN
cord-006139-9063uhox	256	12	of	of	IN
cord-006139-9063uhox	256	13	chloroquine	chloroquine	NN
cord-006139-9063uhox	256	14	-	-	HYPH
cord-006139-9063uhox	256	15	resistant	resistant	JJ
cord-006139-9063uhox	256	16	parasite	parasite	NN
cord-006139-9063uhox	256	17	strains	strain	NNS
cord-006139-9063uhox	256	18	,	,	,
cord-006139-9063uhox	256	19	to	to	TO
cord-006139-9063uhox	256	20	exhibit	exhibit	VB
cord-006139-9063uhox	256	21	little	little	JJ
cord-006139-9063uhox	256	22	cytotoxicity	cytotoxicity	NN
cord-006139-9063uhox	256	23	and	and	CC
cord-006139-9063uhox	256	24	to	to	TO
cord-006139-9063uhox	256	25	be	be	VB
cord-006139-9063uhox	256	26	curative	curative	JJ
cord-006139-9063uhox	256	27	for	for	IN
cord-006139-9063uhox	256	28	mouse	mouse	NN
cord-006139-9063uhox	256	29	malaria	malaria	NN
cord-006139-9063uhox	256	30	.	.	.
cord-006139-9063uhox	257	1	n	n	CC
cord-006139-9063uhox	257	2	Dual	dual	JJ
cord-006139-9063uhox	257	3	-	-	HYPH
cord-006139-9063uhox	257	4	function	function	NN
cord-006139-9063uhox	257	5	antimalarials	antimalarial	NNS
cord-006139-9063uhox	257	6	that	that	WDT
cord-006139-9063uhox	257	7	inhibit	inhibit	VBP
cord-006139-9063uhox	257	8	chloroquine	chloroquine	NN
cord-006139-9063uhox	257	9	transport	transport	NN
cord-006139-9063uhox	257	10	by	by	IN
cord-006139-9063uhox	257	11	PfCRT	PfCRT	NNP
cord-006139-9063uhox	257	12	are	be	VBP
cord-006139-9063uhox	257	13	innovative	innovative	JJ
cord-006139-9063uhox	257	14	compounds	compound	NNS
cord-006139-9063uhox	257	15	that	that	WDT
cord-006139-9063uhox	257	16	have	have	VBP
cord-006139-9063uhox	257	17	been	be	VBN
cord-006139-9063uhox	257	18	shown	show	VBN
cord-006139-9063uhox	257	19	to	to	TO
cord-006139-9063uhox	257	20	have	have	VB
cord-006139-9063uhox	257	21	good	good	JJ
cord-006139-9063uhox	257	22	activity	activity	NN
cord-006139-9063uhox	257	23	,	,	,
cord-006139-9063uhox	257	24	including	include	VBG
cord-006139-9063uhox	257	25	oral	oral	JJ
cord-006139-9063uhox	257	26	activity	activity	NN
cord-006139-9063uhox	257	27	in	in	IN
cord-006139-9063uhox	257	28	mice	mouse	NNS
cord-006139-9063uhox	257	29	.	.	.
cord-006139-9063uhox	258	1	n	n	LS
cord-006139-9063uhox	258	2	Obstacles	obstacle	NNS
cord-006139-9063uhox	258	3	to	to	IN
cord-006139-9063uhox	258	4	future	future	JJ
cord-006139-9063uhox	258	5	development	development	NN
cord-006139-9063uhox	258	6	do	do	VBP
cord-006139-9063uhox	258	7	,	,	,
cord-006139-9063uhox	258	8	however	however	RB
cord-006139-9063uhox	258	9	,	,	,
cord-006139-9063uhox	258	10	exist	exist	VBP
cord-006139-9063uhox	258	11	.	.	.
cord-006139-9063uhox	259	1	These	these	DT
cord-006139-9063uhox	259	2	include	include	VBP
cord-006139-9063uhox	259	3	potential	potential	NN
cord-006139-9063uhox	259	4	for	for	IN
cord-006139-9063uhox	259	5	hERG	herg	NN
cord-006139-9063uhox	259	6	toxicity	toxicity	NN
cord-006139-9063uhox	259	7	,	,	,
cord-006139-9063uhox	259	8	the	the	DT
cord-006139-9063uhox	259	9	possibility	possibility	NN
cord-006139-9063uhox	259	10	of	of	IN
cord-006139-9063uhox	259	11	increased	increase	VBN
cord-006139-9063uhox	259	12	potential	potential	NN
cord-006139-9063uhox	259	13	for	for	IN
cord-006139-9063uhox	259	14	the	the	DT
cord-006139-9063uhox	259	15	development	development	NN
cord-006139-9063uhox	259	16	of	of	IN
cord-006139-9063uhox	259	17	resistance	resistance	NN
cord-006139-9063uhox	259	18	resulting	result	VBG
cord-006139-9063uhox	259	19	from	from	IN
cord-006139-9063uhox	259	20	interaction	interaction	NN
cord-006139-9063uhox	259	21	with	with	IN
cord-006139-9063uhox	259	22	PfCRT	PfCRT	NNP
cord-006139-9063uhox	259	23	and	and	CC
cord-006139-9063uhox	259	24	the	the	DT
cord-006139-9063uhox	259	25	need	need	NN
cord-006139-9063uhox	259	26	to	to	TO
cord-006139-9063uhox	259	27	compete	compete	VB
cord-006139-9063uhox	259	28	with	with	IN
cord-006139-9063uhox	259	29	numerous	numerous	JJ
cord-006139-9063uhox	259	30	other	other	JJ
cord-006139-9063uhox	259	31	quinoline	quinoline	JJ
cord-006139-9063uhox	259	32	antimalarials	antimalarial	NNS
cord-006139-9063uhox	259	33	.	.	.
cord-006139-9063uhox	260	1	Dual	dual	JJ
cord-006139-9063uhox	260	2	-	-	HYPH
cord-006139-9063uhox	260	3	functioning	function	VBG
cord-006139-9063uhox	260	4	antimalarials	antimalarial	NNS
cord-006139-9063uhox	260	5	that	that	WDT
cord-006139-9063uhox	260	6	inhibit	inhibit	VBP
cord-006139-9063uhox	260	7	the	the	DT
cord-006139-9063uhox	260	8	chloroquine	chloroquine	NN
cord-006139-9063uhox	260	9	-	-	HYPH
cord-006139-9063uhox	260	10	resistance	resistance	NN
cord-006139-9063uhox	260	11	transporter	transporter	NN
cord-006139-9063uhox	260	12	Review	Review	NNP
cord-006139-9063uhox	260	13	future	future	JJ
cord-006139-9063uhox	260	14	science	science	NN
cord-006139-9063uhox	260	15	group	group	NN
cord-006139-9063uhox	260	16	explored	explore	VBD
cord-006139-9063uhox	260	17	.	.	.
cord-006139-9063uhox	261	1	Lack	lack	NN
cord-006139-9063uhox	261	2	of	of	IN
cord-006139-9063uhox	261	3	activity	activity	NN
cord-006139-9063uhox	261	4	against	against	IN
cord-006139-9063uhox	261	5	such	such	JJ
cord-006139-9063uhox	261	6	strains	strain	NNS
cord-006139-9063uhox	261	7	is	be	VBZ
cord-006139-9063uhox	261	8	potentially	potentially	RB
cord-006139-9063uhox	261	9	a	a	DT
cord-006139-9063uhox	261	10	risk	risk	NN
cord-006139-9063uhox	261	11	factor	factor	NN
cord-006139-9063uhox	261	12	for	for	IN
cord-006139-9063uhox	261	13	these	these	DT
cord-006139-9063uhox	261	14	compounds	compound	NNS
cord-006139-9063uhox	261	15	.	.	.
cord-006139-9063uhox	262	1	The	the	DT
cord-006139-9063uhox	262	2	final	final	JJ
cord-006139-9063uhox	262	3	and	and	CC
cord-006139-9063uhox	262	4	probably	probably	RB
cord-006139-9063uhox	262	5	most	most	RBS
cord-006139-9063uhox	262	6	difficult	difficult	JJ
cord-006139-9063uhox	262	7	hurdle	hurdle	NN
cord-006139-9063uhox	262	8	is	be	VBZ
cord-006139-9063uhox	262	9	not	not	RB
cord-006139-9063uhox	262	10	a	a	DT
cord-006139-9063uhox	262	11	technical	technical	JJ
cord-006139-9063uhox	262	12	one	one	CD
cord-006139-9063uhox	262	13	.	.	.
cord-006139-9063uhox	263	1	Currently	currently	RB
cord-006139-9063uhox	263	2	,	,	,
cord-006139-9063uhox	263	3	as	as	IN
cord-006139-9063uhox	263	4	noted	note	VBN
cord-006139-9063uhox	263	5	earlier	early	RBR
cord-006139-9063uhox	263	6	,	,	,
cord-006139-9063uhox	263	7	a	a	DT
cord-006139-9063uhox	263	8	number	number	NN
cord-006139-9063uhox	263	9	of	of	IN
cord-006139-9063uhox	263	10	new	new	JJ
cord-006139-9063uhox	263	11	quinolines	quinoline	NNS
cord-006139-9063uhox	263	12	and	and	CC
cord-006139-9063uhox	263	13	related	relate	VBN
cord-006139-9063uhox	263	14	compounds	compound	NNS
cord-006139-9063uhox	263	15	are	be	VBP
cord-006139-9063uhox	263	16	in	in	IN
cord-006139-9063uhox	263	17	development	development	NN
cord-006139-9063uhox	263	18	.	.	.
cord-006139-9063uhox	264	1	In	in	IN
cord-006139-9063uhox	264	2	addition	addition	NN
cord-006139-9063uhox	264	3	,	,	,
cord-006139-9063uhox	264	4	there	there	EX
cord-006139-9063uhox	264	5	are	be	VBP
cord-006139-9063uhox	264	6	several	several	JJ
cord-006139-9063uhox	264	7	such	such	JJ
cord-006139-9063uhox	264	8	compounds	compound	NNS
cord-006139-9063uhox	264	9	in	in	IN
cord-006139-9063uhox	264	10	current	current	JJ
cord-006139-9063uhox	264	11	use	use	NN
cord-006139-9063uhox	264	12	.	.	.
cord-006139-9063uhox	265	1	Obtaining	obtain	VBG
cord-006139-9063uhox	265	2	the	the	DT
cord-006139-9063uhox	265	3	necessary	necessary	JJ
cord-006139-9063uhox	265	4	support	support	NN
cord-006139-9063uhox	265	5	to	to	TO
cord-006139-9063uhox	265	6	develop	develop	VB
cord-006139-9063uhox	265	7	yet	yet	RB
cord-006139-9063uhox	265	8	another	another	DT
cord-006139-9063uhox	265	9	set	set	NN
cord-006139-9063uhox	265	10	of	of	IN
cord-006139-9063uhox	265	11	quinoline	quinoline	JJ
cord-006139-9063uhox	265	12	compounds	compound	NNS
cord-006139-9063uhox	265	13	under	under	IN
cord-006139-9063uhox	265	14	these	these	DT
cord-006139-9063uhox	265	15	circumstances	circumstance	NNS
cord-006139-9063uhox	265	16	is	be	VBZ
cord-006139-9063uhox	265	17	likely	likely	JJ
cord-006139-9063uhox	265	18	to	to	TO
cord-006139-9063uhox	265	19	be	be	VB
cord-006139-9063uhox	265	20	a	a	DT
cord-006139-9063uhox	265	21	major	major	JJ
cord-006139-9063uhox	265	22	challenge	challenge	NN
cord-006139-9063uhox	265	23	and	and	CC
cord-006139-9063uhox	265	24	probably	probably	RB
cord-006139-9063uhox	265	25	represents	represent	VBZ
cord-006139-9063uhox	265	26	the	the	DT
cord-006139-9063uhox	265	27	single	single	JJ
cord-006139-9063uhox	265	28	biggest	big	JJS
cord-006139-9063uhox	265	29	hurdle	hurdle	NN
cord-006139-9063uhox	265	30	to	to	IN
cord-006139-9063uhox	265	31	further	further	JJ
cord-006139-9063uhox	265	32	development	development	NN
cord-006139-9063uhox	265	33	of	of	IN
cord-006139-9063uhox	265	34	this	this	DT
cord-006139-9063uhox	265	35	class	class	NN
cord-006139-9063uhox	265	36	of	of	IN
cord-006139-9063uhox	265	37	compound	compound	NN
cord-006139-9063uhox	265	38	.	.	.
cord-006139-9063uhox	266	1	Despite	despite	IN
cord-006139-9063uhox	266	2	the	the	DT
cord-006139-9063uhox	266	3	challenges	challenge	NNS
cord-006139-9063uhox	266	4	noted	note	VBN
cord-006139-9063uhox	266	5	above	above	RB
cord-006139-9063uhox	266	6	,	,	,
cord-006139-9063uhox	266	7	the	the	DT
cord-006139-9063uhox	266	8	dualfunction	dualfunction	NN
cord-006139-9063uhox	266	9	antimalarials	antimalarial	NNS
cord-006139-9063uhox	266	10	that	that	WDT
cord-006139-9063uhox	266	11	act	act	VBP
cord-006139-9063uhox	266	12	against	against	IN
cord-006139-9063uhox	266	13	both	both	DT
cord-006139-9063uhox	266	14	hemozoin	hemozoin	NNP
cord-006139-9063uhox	266	15	formation	formation	NN
cord-006139-9063uhox	266	16	in	in	IN
cord-006139-9063uhox	266	17	the	the	DT
cord-006139-9063uhox	266	18	parasite	parasite	NN
cord-006139-9063uhox	266	19	and	and	CC
cord-006139-9063uhox	266	20	chloroquineresistant	chloroquineresistant	NN
cord-006139-9063uhox	266	21	mutants	mutant	NNS
cord-006139-9063uhox	266	22	of	of	IN
cord-006139-9063uhox	266	23	PfCRT	PfCRT	NNPS
cord-006139-9063uhox	266	24	represent	represent	VBP
cord-006139-9063uhox	266	25	a	a	DT
cord-006139-9063uhox	266	26	unique	unique	JJ
cord-006139-9063uhox	266	27	series	series	NN
cord-006139-9063uhox	266	28	of	of	IN
cord-006139-9063uhox	266	29	molecules	molecule	NNS
cord-006139-9063uhox	266	30	with	with	IN
cord-006139-9063uhox	266	31	considerable	considerable	JJ
cord-006139-9063uhox	266	32	potential	potential	NN
cord-006139-9063uhox	266	33	as	as	IN
cord-006139-9063uhox	266	34	antimalarials	antimalarial	NNS
cord-006139-9063uhox	266	35	.	.	.
cord-006139-9063uhox	267	1	Combinations	combination	NNS
cord-006139-9063uhox	267	2	with	with	IN
cord-006139-9063uhox	267	3	existing	exist	VBG
cord-006139-9063uhox	267	4	quinolines	quinoline	NNS
cord-006139-9063uhox	267	5	and	and	CC
cord-006139-9063uhox	267	6	related	relate	VBN
cord-006139-9063uhox	267	7	compounds	compound	NNS
cord-006139-9063uhox	267	8	,	,	,
cord-006139-9063uhox	267	9	including	include	VBG
cord-006139-9063uhox	267	10	chloroquine	chloroquine	NN
cord-006139-9063uhox	267	11	,	,	,
cord-006139-9063uhox	267	12	amodiaquine	amodiaquine	NN
cord-006139-9063uhox	267	13	and	and	CC
cord-006139-9063uhox	267	14	quinine	quinine	NN
cord-006139-9063uhox	267	15	,	,	,
cord-006139-9063uhox	267	16	which	which	WDT
cord-006139-9063uhox	267	17	are	be	VBP
cord-006139-9063uhox	267	18	all	all	DT
cord-006139-9063uhox	267	19	thought	think	VBN
cord-006139-9063uhox	267	20	to	to	TO
cord-006139-9063uhox	267	21	be	be	VB
cord-006139-9063uhox	267	22	transported	transport	VBN
cord-006139-9063uhox	267	23	by	by	IN
cord-006139-9063uhox	267	24	PfCRT	PfCRT	NNP
cord-006139-9063uhox	267	25	,	,	,
cord-006139-9063uhox	267	26	are	be	VBP
cord-006139-9063uhox	267	27	likely	likely	JJ
cord-006139-9063uhox	267	28	to	to	TO
cord-006139-9063uhox	267	29	result	result	VB
cord-006139-9063uhox	267	30	in	in	IN
cord-006139-9063uhox	267	31	considerably	considerably	RB
cord-006139-9063uhox	267	32	enhanced	enhance	VBN
cord-006139-9063uhox	267	33	activities	activity	NNS
cord-006139-9063uhox	267	34	in	in	IN
cord-006139-9063uhox	267	35	drug	drug	NN
cord-006139-9063uhox	267	36	-	-	HYPH
cord-006139-9063uhox	267	37	resistant	resistant	JJ
cord-006139-9063uhox	267	38	strains	strain	NNS
cord-006139-9063uhox	267	39	.	.	.
cord-006139-9063uhox	268	1	In	in	IN
cord-006139-9063uhox	268	2	common	common	JJ
cord-006139-9063uhox	268	3	with	with	IN
cord-006139-9063uhox	268	4	the	the	DT
cord-006139-9063uhox	268	5	other	other	JJ
cord-006139-9063uhox	268	6	quinolines	quinoline	NNS
cord-006139-9063uhox	268	7	,	,	,
cord-006139-9063uhox	268	8	they	-PRON-	PRP
cord-006139-9063uhox	268	9	are	be	VBP
cord-006139-9063uhox	268	10	readily	readily	RB
cord-006139-9063uhox	268	11	amenable	amenable	JJ
cord-006139-9063uhox	268	12	to	to	IN
cord-006139-9063uhox	268	13	synthesis	synthesis	NN
cord-006139-9063uhox	268	14	and	and	CC
cord-006139-9063uhox	268	15	are	be	VBP
cord-006139-9063uhox	268	16	potentially	potentially	RB
cord-006139-9063uhox	268	17	cheap	cheap	JJ
cord-006139-9063uhox	268	18	to	to	TO
cord-006139-9063uhox	268	19	produce	produce	VB
cord-006139-9063uhox	268	20	.	.	.
cord-006139-9063uhox	269	1	In	in	IN
cord-006139-9063uhox	269	2	this	this	DT
cord-006139-9063uhox	269	3	regard	regard	NN
cord-006139-9063uhox	269	4	,	,	,
cord-006139-9063uhox	269	5	further	further	JJ
cord-006139-9063uhox	269	6	investigation	investigation	NN
cord-006139-9063uhox	269	7	of	of	IN
cord-006139-9063uhox	269	8	this	this	DT
cord-006139-9063uhox	269	9	class	class	NN
cord-006139-9063uhox	269	10	of	of	IN
cord-006139-9063uhox	269	11	compound	compound	NN
cord-006139-9063uhox	269	12	is	be	VBZ
cord-006139-9063uhox	269	13	well	well	RB
cord-006139-9063uhox	269	14	justified	justified	JJ
cord-006139-9063uhox	269	15	.	.	.
cord-006139-9063uhox	269	16	 	 	_SP
cord-006139-9063uhox	270	1	A	a	DT
cord-006139-9063uhox	270	2	large	large	JJ
cord-006139-9063uhox	270	3	focus	focus	NN
cord-006139-9063uhox	270	4	of	of	IN
cord-006139-9063uhox	270	5	naturally	naturally	RB
cord-006139-9063uhox	270	6	acquired	acquire	VBN
cord-006139-9063uhox	270	7	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	270	8	knowlesi	knowlesi	JJ
cord-006139-9063uhox	270	9	infections	infection	NNS
cord-006139-9063uhox	270	10	in	in	IN
cord-006139-9063uhox	270	11	human	human	JJ
cord-006139-9063uhox	270	12	beings	being	NNS
cord-006139-9063uhox	270	13	Insecticide	Insecticide	NNP
cord-006139-9063uhox	270	14	-	-	HYPH
cord-006139-9063uhox	270	15	treated	treat	VBN
cord-006139-9063uhox	270	16	bed	bed	NN
cord-006139-9063uhox	270	17	nets	net	NNS
cord-006139-9063uhox	270	18	and	and	CC
cord-006139-9063uhox	270	19	curtains	curtain	NNS
cord-006139-9063uhox	270	20	for	for	IN
cord-006139-9063uhox	270	21	preventing	prevent	VBG
cord-006139-9063uhox	270	22	malaria	malaria	NN
cord-006139-9063uhox	270	23	Seven	seven	CD
cord-006139-9063uhox	270	24	years	year	NNS
cord-006139-9063uhox	270	25	of	of	IN
cord-006139-9063uhox	270	26	regional	regional	JJ
cord-006139-9063uhox	270	27	malaria	malaria	NN
cord-006139-9063uhox	270	28	control	control	NN
cord-006139-9063uhox	270	29	collaboration	collaboration	NN
cord-006139-9063uhox	270	30	-Mozamibique	-Mozamibique	NNP
cord-006139-9063uhox	270	31	,	,	,
cord-006139-9063uhox	270	32	South	South	NNP
cord-006139-9063uhox	270	33	Africa	Africa	NNP
cord-006139-9063uhox	270	34	and	and	CC
cord-006139-9063uhox	270	35	Swaziland	Swaziland	NNP
cord-006139-9063uhox	270	36	Impact	Impact	NNP
cord-006139-9063uhox	270	37	of	of	IN
cord-006139-9063uhox	270	38	artemisinin	artemisinin	NN
cord-006139-9063uhox	270	39	-	-	HYPH
cord-006139-9063uhox	270	40	based	base	VBN
cord-006139-9063uhox	270	41	combination	combination	NN
cord-006139-9063uhox	270	42	therapy	therapy	NN
cord-006139-9063uhox	270	43	and	and	CC
cord-006139-9063uhox	270	44	insecticide	insecticide	NN
cord-006139-9063uhox	270	45	-	-	HYPH
cord-006139-9063uhox	270	46	treated	treat	VBN
cord-006139-9063uhox	270	47	nets	net	NNS
cord-006139-9063uhox	270	48	on	on	IN
cord-006139-9063uhox	270	49	malaria	malaria	NN
cord-006139-9063uhox	270	50	burden	burden	NN
cord-006139-9063uhox	270	51	in	in	IN
cord-006139-9063uhox	270	52	Zanzibar	Zanzibar	NNP
cord-006139-9063uhox	270	53	Evidence	evidence	NN
cord-006139-9063uhox	270	54	of	of	IN
cord-006139-9063uhox	270	55	artemisinin	artemisinin	NN
cord-006139-9063uhox	270	56	-	-	HYPH
cord-006139-9063uhox	270	57	resistant	resistant	JJ
cord-006139-9063uhox	270	58	malaria	malaria	NN
cord-006139-9063uhox	270	59	in	in	IN
cord-006139-9063uhox	270	60	western	western	JJ
cord-006139-9063uhox	270	61	Cambodia	Cambodia	NNP
cord-006139-9063uhox	270	62	n	n	CC
cord-006139-9063uhox	270	63	First	First	NNP
cord-006139-9063uhox	270	64	report	report	NN
cord-006139-9063uhox	270	65	of	of	IN
cord-006139-9063uhox	270	66	reduced	reduced	JJ
cord-006139-9063uhox	270	67	susceptibility	susceptibility	NN
cord-006139-9063uhox	270	68	of	of	IN
cord-006139-9063uhox	270	69	clinical	clinical	JJ
cord-006139-9063uhox	270	70	malaria	malaria	NN
cord-006139-9063uhox	270	71	to	to	IN
cord-006139-9063uhox	270	72	artemisinin	artemisinin	NN
cord-006139-9063uhox	270	73	treatment	treatment	NN
cord-006139-9063uhox	271	1	Artemisinin	Artemisinin	NNP
cord-006139-9063uhox	271	2	resistance	resistance	NN
cord-006139-9063uhox	271	3	in	in	IN
cord-006139-9063uhox	271	4	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	271	5	falciparum	falciparum	NN
cord-006139-9063uhox	271	6	malaria	malaria	VBP
cord-006139-9063uhox	271	7	Emergence	emergence	NN
cord-006139-9063uhox	271	8	of	of	IN
cord-006139-9063uhox	271	9	artemisinin	artemisinin	NN
cord-006139-9063uhox	271	10	-	-	HYPH
cord-006139-9063uhox	271	11	resistant	resistant	JJ
cord-006139-9063uhox	271	12	malaria	malaria	NN
cord-006139-9063uhox	271	13	on	on	IN
cord-006139-9063uhox	271	14	the	the	DT
cord-006139-9063uhox	271	15	western	western	JJ
cord-006139-9063uhox	271	16	border	border	NN
cord-006139-9063uhox	271	17	of	of	IN
cord-006139-9063uhox	271	18	Thailand	Thailand	NNP
cord-006139-9063uhox	271	19	:	:	:
cord-006139-9063uhox	271	20	a	a	DT
cord-006139-9063uhox	271	21	longitudinal	longitudinal	JJ
cord-006139-9063uhox	271	22	study	study	NN
cord-006139-9063uhox	271	23	Guidlines	Guidlines	NNPS
cord-006139-9063uhox	271	24	for	for	IN
cord-006139-9063uhox	271	25	the	the	DT
cord-006139-9063uhox	271	26	Treatment	Treatment	NNP
cord-006139-9063uhox	271	27	of	of	IN
cord-006139-9063uhox	271	28	Malaria	Malaria	NNP
cord-006139-9063uhox	271	29	:	:	:
cord-006139-9063uhox	271	30	Global	Global	NNP
cord-006139-9063uhox	271	31	Malaria	Malaria	NNP
cord-006139-9063uhox	271	32	Programme	Programme	NNP
cord-006139-9063uhox	271	33	.	.	.
cord-006139-9063uhox	272	1	WHO	who	WP
cord-006139-9063uhox	272	2	Amodiaquine	Amodiaquine	NNP
cord-006139-9063uhox	272	3	resistant	resistant	JJ
cord-006139-9063uhox	272	4	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	272	5	falciparum	falciparum	NN
cord-006139-9063uhox	272	6	malaria	malaria	NN
cord-006139-9063uhox	272	7	in	in	IN
cord-006139-9063uhox	272	8	vivo	vivo	NNP
cord-006139-9063uhox	272	9	is	be	VBZ
cord-006139-9063uhox	272	10	associated	associate	VBN
cord-006139-9063uhox	272	11	with	with	IN
cord-006139-9063uhox	272	12	selection	selection	NN
cord-006139-9063uhox	272	13	of	of	IN
cord-006139-9063uhox	272	14	pfcrt	pfcrt	NNP
cord-006139-9063uhox	272	15	76	76	CD
cord-006139-9063uhox	272	16	T	T	NNP
cord-006139-9063uhox	272	17	and	and	CC
cord-006139-9063uhox	272	18	pfmdr1	pfmdr1	NNP
cord-006139-9063uhox	272	19	86Y	86y	CD
cord-006139-9063uhox	273	1	In	in	IN
cord-006139-9063uhox	273	2	vivo	vivo	NN
cord-006139-9063uhox	273	3	selection	selection	NN
cord-006139-9063uhox	273	4	of	of	IN
cord-006139-9063uhox	273	5	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	273	6	falciparum	falciparum	NN
cord-006139-9063uhox	273	7	pfmdr1	pfmdr1	NN
cord-006139-9063uhox	273	8	86N	86n	CD
cord-006139-9063uhox	273	9	coding	code	VBG
cord-006139-9063uhox	273	10	alleles	allele	NNS
cord-006139-9063uhox	273	11	by	by	IN
cord-006139-9063uhox	273	12	artemetherlumefantrine	artemetherlumefantrine	NN
cord-006139-9063uhox	273	13	(	(	-LRB-
cord-006139-9063uhox	273	14	Coartem	Coartem	NNP
cord-006139-9063uhox	273	15	)	)	-RRB-
cord-006139-9063uhox	273	16	New	new	JJ
cord-006139-9063uhox	273	17	medicines	medicine	NNS
cord-006139-9063uhox	273	18	to	to	TO
cord-006139-9063uhox	273	19	combat	combat	VB
cord-006139-9063uhox	273	20	malaria	malaria	NN
cord-006139-9063uhox	273	21	:	:	:
cord-006139-9063uhox	273	22	an	an	DT
cord-006139-9063uhox	273	23	overview	overview	NN
cord-006139-9063uhox	273	24	of	of	IN
cord-006139-9063uhox	273	25	the	the	DT
cord-006139-9063uhox	273	26	global	global	JJ
cord-006139-9063uhox	273	27	pipeline	pipeline	NN
cord-006139-9063uhox	273	28	of	of	IN
cord-006139-9063uhox	273	29	therapeutics	therapeutic	NNS
cord-006139-9063uhox	273	30	Bioorganometallic	Bioorganometallic	NNP
cord-006139-9063uhox	273	31	chemistry	chemistry	NN
cord-006139-9063uhox	273	32	and	and	CC
cord-006139-9063uhox	273	33	malaria	malaria	NN
cord-006139-9063uhox	273	34	.	.	.
cord-006139-9063uhox	274	1	Top	Top	NNP
cord-006139-9063uhox	274	2	Fate	Fate	NNP
cord-006139-9063uhox	274	3	of	of	IN
cord-006139-9063uhox	274	4	haem	haem	NN
cord-006139-9063uhox	274	5	iron	iron	NN
cord-006139-9063uhox	274	6	in	in	IN
cord-006139-9063uhox	274	7	the	the	DT
cord-006139-9063uhox	274	8	malaria	malaria	NN
cord-006139-9063uhox	274	9	parasite	parasite	NN
cord-006139-9063uhox	274	10	Plasmodium	plasmodium	NN
cord-006139-9063uhox	274	11	falciparum	falciparum	NN
cord-006139-9063uhox	275	1	The	the	DT
cord-006139-9063uhox	275	2	crystal	crystal	JJ
cord-006139-9063uhox	275	3	structure	structure	NN
cord-006139-9063uhox	275	4	of	of	IN
cord-006139-9063uhox	275	5	superoxide	superoxide	NN
cord-006139-9063uhox	275	6	dismutase	dismutase	NN
cord-006139-9063uhox	275	7	from	from	IN
cord-006139-9063uhox	275	8	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	275	9	falciparum	falciparum	NN
cord-006139-9063uhox	276	1	The	the	DT
cord-006139-9063uhox	276	2	malarial	malarial	JJ
cord-006139-9063uhox	276	3	parasite	parasite	NN
cord-006139-9063uhox	276	4	Plasmodium	plasmodium	NN
cord-006139-9063uhox	276	5	falciparum	falciparum	NN
cord-006139-9063uhox	276	6	imports	import	VBZ
cord-006139-9063uhox	276	7	the	the	DT
cord-006139-9063uhox	276	8	human	human	JJ
cord-006139-9063uhox	276	9	protein	protein	NN
cord-006139-9063uhox	276	10	peroxiredoxin	peroxiredoxin	NNP
cord-006139-9063uhox	276	11	2	2	CD
cord-006139-9063uhox	276	12	for	for	IN
cord-006139-9063uhox	276	13	peroxide	peroxide	NN
cord-006139-9063uhox	276	14	detoxification	detoxification	NN
cord-006139-9063uhox	276	15	Structure	structure	NN
cord-006139-9063uhox	276	16	of	of	IN
cord-006139-9063uhox	276	17	the	the	DT
cord-006139-9063uhox	276	18	amodiaquine	amodiaquine	NNP
cord-006139-9063uhox	276	19	-	-	HYPH
cord-006139-9063uhox	276	20	FPIX	FPIX	NNP
cord-006139-9063uhox	276	21	µ-oxo	µ-oxo	VBP
cord-006139-9063uhox	276	22	dimer	dimer	NN
cord-006139-9063uhox	276	23	solution	solution	NN
cord-006139-9063uhox	276	24	complex	complex	NN
cord-006139-9063uhox	276	25	at	at	IN
cord-006139-9063uhox	276	26	atomic	atomic	JJ
cord-006139-9063uhox	276	27	resolution	resolution	NN
cord-006139-9063uhox	276	28	NMR	NMR	NNP
cord-006139-9063uhox	276	29	studies	study	NNS
cord-006139-9063uhox	276	30	of	of	IN
cord-006139-9063uhox	276	31	chloroquineferriprotoporphyrin	chloroquineferriprotoporphyrin	NNP
cord-006139-9063uhox	276	32	IX	IX	NNP
cord-006139-9063uhox	276	33	complex	complex	JJ
cord-006139-9063uhox	276	34	Spin	Spin	NNP
cord-006139-9063uhox	276	35	state	state	NN
cord-006139-9063uhox	276	36	of	of	IN
cord-006139-9063uhox	276	37	chloroquine	chloroquine	NN
cord-006139-9063uhox	276	38	-	-	HYPH
cord-006139-9063uhox	276	39	heme	heme	NN
cord-006139-9063uhox	276	40	complexes	complex	NNS
cord-006139-9063uhox	276	41	:	:	:
cord-006139-9063uhox	277	1	formation	formation	NN
cord-006139-9063uhox	277	2	of	of	IN
cord-006139-9063uhox	277	3	a	a	DT
cord-006139-9063uhox	277	4	hemin	hemin	NNP
cord-006139-9063uhox	277	5	tetramer	tetramer	NN
cord-006139-9063uhox	277	6	adduct	adduct	NN
cord-006139-9063uhox	277	7	Mapping	Mapping	NNP
cord-006139-9063uhox	277	8	antimalarial	antimalarial	JJ
cord-006139-9063uhox	277	9	pharmacophores	pharmacophore	NNS
cord-006139-9063uhox	277	10	as	as	IN
cord-006139-9063uhox	277	11	a	a	DT
cord-006139-9063uhox	277	12	useful	useful	JJ
cord-006139-9063uhox	277	13	tool	tool	NN
cord-006139-9063uhox	277	14	for	for	IN
cord-006139-9063uhox	277	15	the	the	DT
cord-006139-9063uhox	277	16	rapid	rapid	JJ
cord-006139-9063uhox	277	17	discovery	discovery	NN
cord-006139-9063uhox	277	18	of	of	IN
cord-006139-9063uhox	277	19	drugs	drug	NNS
cord-006139-9063uhox	277	20	effective	effective	JJ
cord-006139-9063uhox	277	21	in	in	IN
cord-006139-9063uhox	277	22	vivo	vivo	NN
cord-006139-9063uhox	277	23	:	:	:
cord-006139-9063uhox	278	1	design	design	NN
cord-006139-9063uhox	278	2	,	,	,
cord-006139-9063uhox	278	3	construction	construction	NN
cord-006139-9063uhox	278	4	,	,	,
cord-006139-9063uhox	278	5	characterization	characterization	NN
cord-006139-9063uhox	278	6	and	and	CC
cord-006139-9063uhox	278	7	pharmacology	pharmacology	NN
cord-006139-9063uhox	278	8	of	of	IN
cord-006139-9063uhox	278	9	metaquine	metaquine	NNP
cord-006139-9063uhox	278	10	Interactions	Interactions	NNPS
cord-006139-9063uhox	278	11	of	of	IN
cord-006139-9063uhox	278	12	quinoline	quinoline	JJ
cord-006139-9063uhox	278	13	antimalarials	antimalarial	NNS
cord-006139-9063uhox	278	14	with	with	IN
cord-006139-9063uhox	278	15	hematin	hematin	NNP
cord-006139-9063uhox	278	16	in	in	IN
cord-006139-9063uhox	278	17	aqueous	aqueous	JJ
cord-006139-9063uhox	278	18	solution	solution	NN
cord-006139-9063uhox	278	19	4-N-	4-n-	NN
cord-006139-9063uhox	278	20	,	,	,
cord-006139-9063uhox	278	21	4-S-	4-s-	CD
cord-006139-9063uhox	278	22	,	,	,
cord-006139-9063uhox	278	23	and	and	CC
cord-006139-9063uhox	278	24	4-O	4-o	CD
cord-006139-9063uhox	278	25	-	-	HYPH
cord-006139-9063uhox	278	26	chloroquine	chloroquine	NN
cord-006139-9063uhox	278	27	analogues	analogue	NNS
cord-006139-9063uhox	278	28	:	:	:
cord-006139-9063uhox	278	29	influence	influence	NN
cord-006139-9063uhox	278	30	of	of	IN
cord-006139-9063uhox	278	31	side	side	NN
cord-006139-9063uhox	278	32	chain	chain	NN
cord-006139-9063uhox	278	33	length	length	NN
cord-006139-9063uhox	278	34	and	and	CC
cord-006139-9063uhox	279	1	quinolyl	quinolyl	NNP
cord-006139-9063uhox	279	2	nitrogen	nitrogen	NNP
cord-006139-9063uhox	279	3	pK	pK	NNP
cord-006139-9063uhox	279	4	a	a	NNP
cord-006139-9063uhox	279	5	on	on	IN
cord-006139-9063uhox	279	6	activity	activity	NN
cord-006139-9063uhox	279	7	vs	vs	IN
cord-006139-9063uhox	279	8	chloroquine	chloroquine	NN
cord-006139-9063uhox	279	9	resistant	resistant	JJ
cord-006139-9063uhox	279	10	malaria	malaria	NN
cord-006139-9063uhox	279	11	Quinoline	Quinoline	NNP
cord-006139-9063uhox	279	12	anti	anti	JJ
cord-006139-9063uhox	279	13	-	-	JJ
cord-006139-9063uhox	279	14	malarial	malarial	JJ
cord-006139-9063uhox	279	15	drugs	drug	NNS
cord-006139-9063uhox	279	16	inhibit	inhibit	VBP
cord-006139-9063uhox	279	17	spontaneous	spontaneous	JJ
cord-006139-9063uhox	279	18	formation	formation	NN
cord-006139-9063uhox	279	19	of	of	IN
cord-006139-9063uhox	279	20	b	b	NN
cord-006139-9063uhox	279	21	-	-	:
cord-006139-9063uhox	279	22	haematin	haematin	NN
cord-006139-9063uhox	279	23	(	(	-LRB-
cord-006139-9063uhox	279	24	malaria	malaria	NN
cord-006139-9063uhox	279	25	pigment	pigment	NN
cord-006139-9063uhox	279	26	)	)	-RRB-
cord-006139-9063uhox	280	1	Antimalarial	antimalarial	JJ
cord-006139-9063uhox	280	2	drugs	drug	NNS
cord-006139-9063uhox	280	3	influence	influence	VBP
cord-006139-9063uhox	280	4	the	the	DT
cord-006139-9063uhox	280	5	pH	pH	NNP
cord-006139-9063uhox	280	6	dependent	dependent	JJ
cord-006139-9063uhox	280	7	solubility	solubility	NN
cord-006139-9063uhox	280	8	of	of	IN
cord-006139-9063uhox	280	9	heme	heme	NN
cord-006139-9063uhox	280	10	via	via	IN
cord-006139-9063uhox	280	11	apparent	apparent	JJ
cord-006139-9063uhox	280	12	nucleation	nucleation	NN
cord-006139-9063uhox	280	13	phenomena	phenomena	VBD
cord-006139-9063uhox	280	14	Quinoline	Quinoline	NNP
cord-006139-9063uhox	280	15	binding	bind	VBG
cord-006139-9063uhox	280	16	site	site	NN
cord-006139-9063uhox	280	17	on	on	IN
cord-006139-9063uhox	280	18	malaria	malaria	NN
cord-006139-9063uhox	280	19	pigment	pigment	NN
cord-006139-9063uhox	280	20	crystal	crystal	NN
cord-006139-9063uhox	280	21	:	:	:
cord-006139-9063uhox	280	22	a	a	DT
cord-006139-9063uhox	280	23	rational	rational	JJ
cord-006139-9063uhox	280	24	pathway	pathway	NN
cord-006139-9063uhox	280	25	for	for	IN
cord-006139-9063uhox	280	26	antimalaria	antimalaria	NNP
cord-006139-9063uhox	280	27	drug	drug	NNP
cord-006139-9063uhox	280	28	design	design	NN
cord-006139-9063uhox	280	29	Crystal	Crystal	NNP
cord-006139-9063uhox	280	30	nucleation	nucleation	NN
cord-006139-9063uhox	280	31	,	,	,
cord-006139-9063uhox	280	32	growth	growth	NN
cord-006139-9063uhox	280	33	,	,	,
cord-006139-9063uhox	280	34	and	and	CC
cord-006139-9063uhox	280	35	morphology	morphology	NN
cord-006139-9063uhox	280	36	of	of	IN
cord-006139-9063uhox	280	37	the	the	DT
cord-006139-9063uhox	280	38	synthetic	synthetic	JJ
cord-006139-9063uhox	280	39	malaria	malaria	NN
cord-006139-9063uhox	280	40	pigment	pigment	NN
cord-006139-9063uhox	280	41	b	b	NN
cord-006139-9063uhox	280	42	-	-	HYPH
cord-006139-9063uhox	280	43	hematin	hematin	NN
cord-006139-9063uhox	280	44	and	and	CC
cord-006139-9063uhox	280	45	the	the	DT
cord-006139-9063uhox	280	46	effect	effect	NN
cord-006139-9063uhox	280	47	thereon	thereon	VBN
cord-006139-9063uhox	280	48	by	by	IN
cord-006139-9063uhox	280	49	quinoline	quinoline	JJ
cord-006139-9063uhox	280	50	additives	additive	NNS
cord-006139-9063uhox	280	51	:	:	:
cord-006139-9063uhox	280	52	the	the	DT
cord-006139-9063uhox	280	53	malaria	malaria	NN
cord-006139-9063uhox	280	54	pigment	pigment	NN
cord-006139-9063uhox	280	55	as	as	IN
cord-006139-9063uhox	280	56	a	a	DT
cord-006139-9063uhox	280	57	target	target	NN
cord-006139-9063uhox	280	58	of	of	IN
cord-006139-9063uhox	280	59	various	various	JJ
cord-006139-9063uhox	280	60	antimalarial	antimalarial	JJ
cord-006139-9063uhox	280	61	drugs	drug	NNS
cord-006139-9063uhox	280	62	Interplay	interplay	VBP
cord-006139-9063uhox	280	63	between	between	IN
cord-006139-9063uhox	280	64	malaria	malaria	NN
cord-006139-9063uhox	280	65	,	,	,
cord-006139-9063uhox	280	66	crystalline	crystalline	JJ
cord-006139-9063uhox	280	67	hemozoin	hemozoin	NNP
cord-006139-9063uhox	280	68	formation	formation	NN
cord-006139-9063uhox	280	69	,	,	,
cord-006139-9063uhox	280	70	and	and	CC
cord-006139-9063uhox	280	71	antimalarial	antimalarial	JJ
cord-006139-9063uhox	280	72	drug	drug	NN
cord-006139-9063uhox	280	73	action	action	NN
cord-006139-9063uhox	280	74	and	and	CC
cord-006139-9063uhox	280	75	design	design	NN
cord-006139-9063uhox	280	76	The	the	DT
cord-006139-9063uhox	280	77	antimalarial	antimalarial	JJ
cord-006139-9063uhox	280	78	ferroquine	ferroquine	NN
cord-006139-9063uhox	280	79	:	:	:
cord-006139-9063uhox	280	80	role	role	NN
cord-006139-9063uhox	280	81	of	of	IN
cord-006139-9063uhox	280	82	the	the	DT
cord-006139-9063uhox	280	83	metal	metal	NN
cord-006139-9063uhox	280	84	and	and	CC
cord-006139-9063uhox	280	85	intramolecular	intramolecular	JJ
cord-006139-9063uhox	280	86	hydrogen	hydrogen	NN
cord-006139-9063uhox	280	87	bond	bond	NN
cord-006139-9063uhox	280	88	in	in	IN
cord-006139-9063uhox	280	89	activity	activity	NN
cord-006139-9063uhox	280	90	and	and	CC
cord-006139-9063uhox	280	91	resistance	resistance	NN
cord-006139-9063uhox	281	1	The	the	DT
cord-006139-9063uhox	281	2	single	single	JJ
cord-006139-9063uhox	281	3	crystal	crystal	NN
cord-006139-9063uhox	281	4	x	x	NN
cord-006139-9063uhox	281	5	-	-	NN
cord-006139-9063uhox	281	6	ray	ray	JJ
cord-006139-9063uhox	281	7	structure	structure	NN
cord-006139-9063uhox	281	8	of	of	IN
cord-006139-9063uhox	281	9	b	b	NN
cord-006139-9063uhox	281	10	-	-	HYPH
cord-006139-9063uhox	281	11	hematin	hematin	NN
cord-006139-9063uhox	281	12	DMSO	DMSO	NNP
cord-006139-9063uhox	281	13	solvate	solvate	NN
cord-006139-9063uhox	281	14	grown	grow	VBN
cord-006139-9063uhox	281	15	in	in	IN
cord-006139-9063uhox	281	16	the	the	DT
cord-006139-9063uhox	281	17	presence	presence	NN
cord-006139-9063uhox	281	18	of	of	IN
cord-006139-9063uhox	281	19	chloroquine	chloroquine	NN
cord-006139-9063uhox	281	20	,	,	,
cord-006139-9063uhox	281	21	a	a	DT
cord-006139-9063uhox	281	22	b	b	NN
cord-006139-9063uhox	281	23	-	-	HYPH
cord-006139-9063uhox	281	24	hematin	hematin	NN
cord-006139-9063uhox	281	25	growthrate	growthrate	NNP
cord-006139-9063uhox	281	26	inhibitor	inhibitor	NN
cord-006139-9063uhox	282	1	On	on	IN
cord-006139-9063uhox	282	2	the	the	DT
cord-006139-9063uhox	282	3	molecular	molecular	JJ
cord-006139-9063uhox	282	4	mechanism	mechanism	NN
cord-006139-9063uhox	282	5	of	of	IN
cord-006139-9063uhox	282	6	chloroquine	chloroquine	NN
cord-006139-9063uhox	282	7	's	's	POS
cord-006139-9063uhox	282	8	antimalarial	antimalarial	JJ
cord-006139-9063uhox	282	9	action	action	NN
cord-006139-9063uhox	282	10	situ	situ	JJ
cord-006139-9063uhox	282	11	nanochemical	nanochemical	NNP
cord-006139-9063uhox	282	12	imaging	imaging	NN
cord-006139-9063uhox	282	13	of	of	IN
cord-006139-9063uhox	282	14	label	label	NN
cord-006139-9063uhox	282	15	-	-	HYPH
cord-006139-9063uhox	282	16	free	free	JJ
cord-006139-9063uhox	282	17	drugs	drug	NNS
cord-006139-9063uhox	282	18	:	:	:
cord-006139-9063uhox	282	19	a	a	DT
cord-006139-9063uhox	282	20	case	case	NN
cord-006139-9063uhox	282	21	study	study	NN
cord-006139-9063uhox	282	22	of	of	IN
cord-006139-9063uhox	282	23	antimalarials	antimalarial	NNS
cord-006139-9063uhox	282	24	in	in	IN
cord-006139-9063uhox	282	25	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	282	26	falciparum	falciparum	NN
cord-006139-9063uhox	282	27	-	-	HYPH
cord-006139-9063uhox	282	28	infected	infect	VBN
cord-006139-9063uhox	282	29	erythrocytes	erythrocyte	NNS
cord-006139-9063uhox	283	1	Spinning	spin	VBG
cord-006139-9063uhox	283	2	disk	disk	NN
cord-006139-9063uhox	283	3	confocal	confocal	JJ
cord-006139-9063uhox	283	4	microscopy	microscopy	NNS
cord-006139-9063uhox	283	5	of	of	IN
cord-006139-9063uhox	283	6	live	live	JJ
cord-006139-9063uhox	283	7	,	,	,
cord-006139-9063uhox	283	8	intraerythrocytic	intraerythrocytic	JJ
cord-006139-9063uhox	283	9	malarial	malarial	JJ
cord-006139-9063uhox	283	10	parasites	parasite	NNS
cord-006139-9063uhox	283	11	.	.	.
cord-006139-9063uhox	284	1	1	1	LS
cord-006139-9063uhox	284	2	.	.	.
cord-006139-9063uhox	285	1	Quantification	quantification	NN
cord-006139-9063uhox	285	2	of	of	IN
cord-006139-9063uhox	285	3	hemozoin	hemozoin	NNP
cord-006139-9063uhox	285	4	development	development	NN
cord-006139-9063uhox	285	5	for	for	IN
cord-006139-9063uhox	285	6	drug	drug	NN
cord-006139-9063uhox	285	7	sensitive	sensitive	JJ
cord-006139-9063uhox	285	8	versus	versus	IN
cord-006139-9063uhox	285	9	resistant	resistant	JJ
cord-006139-9063uhox	285	10	malaria	malaria	NN
cord-006139-9063uhox	285	11	Antimalarial	Antimalarial	NNP
cord-006139-9063uhox	285	12	quinolines	quinoline	NNS
cord-006139-9063uhox	285	13	and	and	CC
cord-006139-9063uhox	285	14	artemisinin	artemisinin	NN
cord-006139-9063uhox	285	15	inhibit	inhibit	VBP
cord-006139-9063uhox	285	16	endocytosis	endocytosis	NN
cord-006139-9063uhox	285	17	in	in	IN
cord-006139-9063uhox	285	18	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	285	19	falciparum	falciparum	NN
cord-006139-9063uhox	285	20	Insights	insight	NNS
cord-006139-9063uhox	285	21	into	into	IN
cord-006139-9063uhox	285	22	the	the	DT
cord-006139-9063uhox	285	23	role	role	NN
cord-006139-9063uhox	285	24	of	of	IN
cord-006139-9063uhox	285	25	heme	heme	NN
cord-006139-9063uhox	285	26	in	in	IN
cord-006139-9063uhox	285	27	the	the	DT
cord-006139-9063uhox	285	28	mechanism	mechanism	NN
cord-006139-9063uhox	285	29	of	of	IN
cord-006139-9063uhox	285	30	action	action	NN
cord-006139-9063uhox	285	31	of	of	IN
cord-006139-9063uhox	285	32	antimalarials	antimalarial	NNS
cord-006139-9063uhox	285	33	nn	nn	NNP
cord-006139-9063uhox	285	34	Demonstrates	demonstrate	VBZ
cord-006139-9063uhox	285	35	that	that	IN
cord-006139-9063uhox	285	36	chloroquine	chloroquine	NN
cord-006139-9063uhox	285	37	inhibits	inhibit	VBZ
cord-006139-9063uhox	285	38	hemozoin	hemozoin	NNP
cord-006139-9063uhox	285	39	formation	formation	NN
cord-006139-9063uhox	285	40	in	in	IN
cord-006139-9063uhox	285	41	the	the	DT
cord-006139-9063uhox	285	42	malaria	malaria	NN
cord-006139-9063uhox	285	43	parasite	parasite	NN
cord-006139-9063uhox	285	44	,	,	,
cord-006139-9063uhox	285	45	with	with	IN
cord-006139-9063uhox	285	46	corresponding	correspond	VBG
cord-006139-9063uhox	285	47	dosedependent	dosedependent	NN
cord-006139-9063uhox	285	48	increases	increase	NNS
cord-006139-9063uhox	285	49	in	in	IN
cord-006139-9063uhox	285	50	free	free	JJ
cord-006139-9063uhox	285	51	Fe(III)heme	fe(iii)heme	CD
cord-006139-9063uhox	285	52	.	.	.
cord-006139-9063uhox	286	1	It	-PRON-	PRP
cord-006139-9063uhox	286	2	also	also	RB
cord-006139-9063uhox	286	3	directly	directly	RB
cord-006139-9063uhox	286	4	demonstrates	demonstrate	VBZ
cord-006139-9063uhox	286	5	redistribution	redistribution	NN
cord-006139-9063uhox	286	6	of	of	IN
cord-006139-9063uhox	286	7	heme	heme	NN
cord-006139-9063uhox	286	8	into	into	IN
cord-006139-9063uhox	286	9	the	the	DT
cord-006139-9063uhox	286	10	parasite	parasite	NN
cord-006139-9063uhox	286	11	cytoplasm	cytoplasm	NN
cord-006139-9063uhox	286	12	and	and	CC
cord-006139-9063uhox	286	13	disruption	disruption	NN
cord-006139-9063uhox	286	14	of	of	IN
cord-006139-9063uhox	286	15	hemozoin	hemozoin	NNP
cord-006139-9063uhox	286	16	structure	structure	NN
cord-006139-9063uhox	286	17	Structural	structural	JJ
cord-006139-9063uhox	286	18	specificity	specificity	NN
cord-006139-9063uhox	286	19	of	of	IN
cord-006139-9063uhox	286	20	chloroquine	chloroquine	NN
cord-006139-9063uhox	286	21	-	-	HYPH
cord-006139-9063uhox	286	22	hematin	hematin	NN
cord-006139-9063uhox	286	23	binding	binding	NN
cord-006139-9063uhox	286	24	related	relate	VBN
cord-006139-9063uhox	286	25	to	to	IN
cord-006139-9063uhox	286	26	inhibition	inhibition	NN
cord-006139-9063uhox	286	27	of	of	IN
cord-006139-9063uhox	286	28	hematin	hematin	NN
cord-006139-9063uhox	286	29	polymerization	polymerization	NN
cord-006139-9063uhox	286	30	and	and	CC
cord-006139-9063uhox	286	31	parasite	parasite	NN
cord-006139-9063uhox	286	32	growth	growth	NN
cord-006139-9063uhox	287	1	Structurefunction	Structurefunction	NNP
cord-006139-9063uhox	287	2	relationships	relationship	NNS
cord-006139-9063uhox	287	3	in	in	IN
cord-006139-9063uhox	287	4	aminoquinolines	aminoquinoline	NNS
cord-006139-9063uhox	287	5	:	:	:
cord-006139-9063uhox	287	6	effect	effect	NN
cord-006139-9063uhox	287	7	of	of	IN
cord-006139-9063uhox	287	8	amino	amino	NN
cord-006139-9063uhox	287	9	and	and	CC
cord-006139-9063uhox	287	10	chloro	chloro	NN
cord-006139-9063uhox	287	11	groups	group	NNS
cord-006139-9063uhox	287	12	on	on	IN
cord-006139-9063uhox	287	13	quinoline	quinoline	NNP
cord-006139-9063uhox	287	14	-	-	HYPH
cord-006139-9063uhox	287	15	hematin	hematin	NN
cord-006139-9063uhox	287	16	complex	complex	JJ
cord-006139-9063uhox	287	17	formation	formation	NN
cord-006139-9063uhox	287	18	,	,	,
cord-006139-9063uhox	287	19	inhibition	inhibition	NN
cord-006139-9063uhox	287	20	of	of	IN
cord-006139-9063uhox	287	21	b	b	NN
cord-006139-9063uhox	287	22	-	-	HYPH
cord-006139-9063uhox	287	23	hematin	hematin	NN
cord-006139-9063uhox	287	24	formation	formation	NN
cord-006139-9063uhox	287	25	,	,	,
cord-006139-9063uhox	287	26	and	and	CC
cord-006139-9063uhox	287	27	antiplasmodial	antiplasmodial	JJ
cord-006139-9063uhox	287	28	activity	activity	NN
cord-006139-9063uhox	287	29	Structure	structure	NN
cord-006139-9063uhox	287	30	-	-	HYPH
cord-006139-9063uhox	287	31	activity	activity	NN
cord-006139-9063uhox	287	32	relationships	relationship	NNS
cord-006139-9063uhox	287	33	in	in	IN
cord-006139-9063uhox	287	34	4-aminoquinoline	4-aminoquinoline	CD
cord-006139-9063uhox	287	35	antiplasmodials	antiplasmodial	NNS
cord-006139-9063uhox	287	36	.	.	.
cord-006139-9063uhox	288	1	The	the	DT
cord-006139-9063uhox	288	2	role	role	NN
cord-006139-9063uhox	288	3	of	of	IN
cord-006139-9063uhox	288	4	the	the	DT
cord-006139-9063uhox	288	5	group	group	NN
cord-006139-9063uhox	288	6	at	at	IN
cord-006139-9063uhox	288	7	the	the	DT
cord-006139-9063uhox	288	8	7-position	7-position	NNP
cord-006139-9063uhox	288	9	Carbon	Carbon	NNP
cord-006139-9063uhox	288	10	isosteres	isostere	NNS
cord-006139-9063uhox	288	11	of	of	IN
cord-006139-9063uhox	288	12	the	the	DT
cord-006139-9063uhox	288	13	4-aminopyridine	4-aminopyridine	CD
cord-006139-9063uhox	288	14	substructure	substructure	NN
cord-006139-9063uhox	288	15	of	of	IN
cord-006139-9063uhox	288	16	chloroquine	chloroquine	NN
cord-006139-9063uhox	288	17	:	:	:
cord-006139-9063uhox	288	18	effects	effect	NNS
cord-006139-9063uhox	288	19	on	on	IN
cord-006139-9063uhox	288	20	pK	pK	NNP
cord-006139-9063uhox	289	1	a	a	LS
cord-006139-9063uhox	289	2	,	,	,
cord-006139-9063uhox	289	3	hematin	hematin	NNP
cord-006139-9063uhox	289	4	binding	binding	NN
cord-006139-9063uhox	289	5	,	,	,
cord-006139-9063uhox	289	6	inhibition	inhibition	NN
cord-006139-9063uhox	289	7	of	of	IN
cord-006139-9063uhox	289	8	hemozoin	hemozoin	NNP
cord-006139-9063uhox	289	9	formation	formation	NN
cord-006139-9063uhox	289	10	,	,	,
cord-006139-9063uhox	289	11	and	and	CC
cord-006139-9063uhox	289	12	parasite	parasite	NN
cord-006139-9063uhox	289	13	growth	growth	NN
cord-006139-9063uhox	289	14	Synthesis	Synthesis	NNP
cord-006139-9063uhox	289	15	of	of	IN
cord-006139-9063uhox	289	16	4-aminoquinolines	4-aminoquinolines	CD
cord-006139-9063uhox	289	17	that	that	WDT
cord-006139-9063uhox	289	18	circumvent	circumvent	VBP
cord-006139-9063uhox	289	19	drug	drug	NN
cord-006139-9063uhox	289	20	resistance	resistance	NN
cord-006139-9063uhox	289	21	in	in	IN
cord-006139-9063uhox	289	22	malaria	malaria	NN
cord-006139-9063uhox	289	23	parasites	parasite	NNS
cord-006139-9063uhox	289	24	Synthesis	Synthesis	NNP
cord-006139-9063uhox	289	25	of	of	IN
cord-006139-9063uhox	289	26	ringsubstituted	ringsubstituted	JJ
cord-006139-9063uhox	289	27	4-aminoquinolines	4-aminoquinolines	CD
cord-006139-9063uhox	289	28	and	and	CC
cord-006139-9063uhox	289	29	evaluation	evaluation	NN
cord-006139-9063uhox	289	30	of	of	IN
cord-006139-9063uhox	289	31	their	-PRON-	PRP$
cord-006139-9063uhox	289	32	antimalarial	antimalarial	JJ
cord-006139-9063uhox	289	33	activities	activity	NNS
cord-006139-9063uhox	289	34	Incorporation	Incorporation	NNP
cord-006139-9063uhox	289	35	of	of	IN
cord-006139-9063uhox	289	36	an	an	DT
cord-006139-9063uhox	289	37	intramolecular	intramolecular	JJ
cord-006139-9063uhox	289	38	hydrogenbonding	hydrogenbonding	NN
cord-006139-9063uhox	289	39	motif	motif	NN
cord-006139-9063uhox	289	40	in	in	IN
cord-006139-9063uhox	289	41	the	the	DT
cord-006139-9063uhox	289	42	side	side	NN
cord-006139-9063uhox	289	43	chain	chain	NN
cord-006139-9063uhox	289	44	of	of	IN
cord-006139-9063uhox	289	45	4-aminoquinolines	4-aminoquinolines	CD
cord-006139-9063uhox	289	46	enhances	enhance	VBZ
cord-006139-9063uhox	289	47	activity	activity	NN
cord-006139-9063uhox	289	48	against	against	IN
cord-006139-9063uhox	289	49	drug	drug	NN
cord-006139-9063uhox	289	50	-	-	HYPH
cord-006139-9063uhox	289	51	resistant	resistant	JJ
cord-006139-9063uhox	289	52	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	289	53	falciparum	falciparum	NN
cord-006139-9063uhox	289	54	Novel	Novel	NNP
cord-006139-9063uhox	289	55	phenothiazine	phenothiazine	NN
cord-006139-9063uhox	289	56	antimalarials	antimalarial	NNS
cord-006139-9063uhox	289	57	:	:	:
cord-006139-9063uhox	289	58	synthesis	synthesis	NN
cord-006139-9063uhox	289	59	,	,	,
cord-006139-9063uhox	289	60	antimalarial	antimalarial	JJ
cord-006139-9063uhox	289	61	activity	activity	NN
cord-006139-9063uhox	289	62	,	,	,
cord-006139-9063uhox	289	63	and	and	CC
cord-006139-9063uhox	289	64	inhibition	inhibition	NN
cord-006139-9063uhox	289	65	of	of	IN
cord-006139-9063uhox	289	66	the	the	DT
cord-006139-9063uhox	289	67	formation	formation	NN
cord-006139-9063uhox	289	68	of	of	IN
cord-006139-9063uhox	289	69	beta	beta	NN
cord-006139-9063uhox	289	70	-	-	HYPH
cord-006139-9063uhox	289	71	haematin	haematin	NN
cord-006139-9063uhox	289	72	Mutations	Mutations	NNPS
cord-006139-9063uhox	289	73	in	in	IN
cord-006139-9063uhox	289	74	the	the	DT
cord-006139-9063uhox	289	75	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	289	76	falciparum	falciparum	NN
cord-006139-9063uhox	289	77	digestive	digestive	JJ
cord-006139-9063uhox	289	78	vacuole	vacuole	NN
cord-006139-9063uhox	289	79	transmembrane	transmembrane	NN
cord-006139-9063uhox	289	80	protein	protein	NN
cord-006139-9063uhox	289	81	PfCRT	PfCRT	NNP
cord-006139-9063uhox	289	82	and	and	CC
cord-006139-9063uhox	289	83	evidence	evidence	NN
cord-006139-9063uhox	289	84	for	for	IN
cord-006139-9063uhox	289	85	their	-PRON-	PRP$
cord-006139-9063uhox	289	86	role	role	NN
cord-006139-9063uhox	289	87	in	in	IN
cord-006139-9063uhox	289	88	chloroquine	chloroquine	NN
cord-006139-9063uhox	289	89	resistance	resistance	NN
cord-006139-9063uhox	289	90	Chloroquine	Chloroquine	NNP
cord-006139-9063uhox	289	91	resistance	resistance	NN
cord-006139-9063uhox	289	92	in	in	IN
cord-006139-9063uhox	289	93	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	289	94	falciparum	falciparum	NN
cord-006139-9063uhox	289	95	malaria	malaria	NN
cord-006139-9063uhox	289	96	parasites	parasite	NNS
cord-006139-9063uhox	289	97	conferred	confer	VBN
cord-006139-9063uhox	289	98	by	by	IN
cord-006139-9063uhox	289	99	pfcrt	pfcrt	NNP
cord-006139-9063uhox	289	100	mutations	mutation	NNS
cord-006139-9063uhox	290	1	Several	several	JJ
cord-006139-9063uhox	290	2	alleles	allele	NNS
cord-006139-9063uhox	290	3	of	of	IN
cord-006139-9063uhox	290	4	the	the	DT
cord-006139-9063uhox	290	5	multidrug	multidrug	NN
cord-006139-9063uhox	290	6	-	-	HYPH
cord-006139-9063uhox	290	7	resistance	resistance	NN
cord-006139-9063uhox	290	8	gene	gene	NN
cord-006139-9063uhox	290	9	are	be	VBP
cord-006139-9063uhox	290	10	closely	closely	RB
cord-006139-9063uhox	290	11	linked	link	VBN
cord-006139-9063uhox	290	12	to	to	IN
cord-006139-9063uhox	290	13	chloroquine	chloroquine	NN
cord-006139-9063uhox	290	14	resistance	resistance	NN
cord-006139-9063uhox	290	15	in	in	IN
cord-006139-9063uhox	290	16	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	290	17	falciparum	falciparum	NN
cord-006139-9063uhox	290	18	Amplification	amplification	NN
cord-006139-9063uhox	290	19	of	of	IN
cord-006139-9063uhox	290	20	a	a	DT
cord-006139-9063uhox	290	21	gene	gene	NN
cord-006139-9063uhox	290	22	related	relate	VBN
cord-006139-9063uhox	290	23	to	to	IN
cord-006139-9063uhox	290	24	mammalian	mammalian	JJ
cord-006139-9063uhox	290	25	mdr	mdr	NNP
cord-006139-9063uhox	290	26	genes	gene	NNS
cord-006139-9063uhox	290	27	in	in	IN
cord-006139-9063uhox	290	28	drug	drug	NN
cord-006139-9063uhox	290	29	-	-	HYPH
cord-006139-9063uhox	290	30	resistant	resistant	JJ
cord-006139-9063uhox	290	31	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	290	32	falciparum	falciparum	NN
cord-006139-9063uhox	290	33	Pgh1	Pgh1	NNP
cord-006139-9063uhox	290	34	modulates	modulate	VBZ
cord-006139-9063uhox	290	35	sensitivity	sensitivity	NN
cord-006139-9063uhox	290	36	and	and	CC
cord-006139-9063uhox	290	37	resistance	resistance	NN
cord-006139-9063uhox	290	38	to	to	IN
cord-006139-9063uhox	290	39	multiple	multiple	JJ
cord-006139-9063uhox	290	40	antimalarials	antimalarial	NNS
cord-006139-9063uhox	290	41	in	in	IN
cord-006139-9063uhox	290	42	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	290	43	falciparum	falciparum	NN
cord-006139-9063uhox	290	44	Geographic	geographic	JJ
cord-006139-9063uhox	290	45	patterns	pattern	NNS
cord-006139-9063uhox	290	46	of	of	IN
cord-006139-9063uhox	290	47	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	290	48	falciparum	falciparum	NN
cord-006139-9063uhox	290	49	drug	drug	NN
cord-006139-9063uhox	290	50	resistance	resistance	NN
cord-006139-9063uhox	290	51	distinguished	distinguish	VBN
cord-006139-9063uhox	290	52	by	by	IN
cord-006139-9063uhox	290	53	differential	differential	JJ
cord-006139-9063uhox	290	54	responses	response	NNS
cord-006139-9063uhox	290	55	to	to	IN
cord-006139-9063uhox	290	56	amodiaquine	amodiaquine	NNP
cord-006139-9063uhox	290	57	and	and	CC
cord-006139-9063uhox	290	58	chloroquine	chloroquine	NN
cord-006139-9063uhox	290	59	Polymorphisms	Polymorphisms	NNPS
cord-006139-9063uhox	290	60	within	within	IN
cord-006139-9063uhox	290	61	PfMDR1	pfmdr1	NN
cord-006139-9063uhox	290	62	alter	alter	VBP
cord-006139-9063uhox	290	63	the	the	DT
cord-006139-9063uhox	290	64	substrate	substrate	JJ
cord-006139-9063uhox	290	65	specificity	specificity	NN
cord-006139-9063uhox	290	66	for	for	IN
cord-006139-9063uhox	290	67	anti	anti	JJ
cord-006139-9063uhox	290	68	-	-	JJ
cord-006139-9063uhox	290	69	malarial	malarial	JJ
cord-006139-9063uhox	290	70	drugs	drug	NNS
cord-006139-9063uhox	290	71	in	in	IN
cord-006139-9063uhox	290	72	Plasmodium	plasmodium	NN
cord-006139-9063uhox	290	73	falciparum	falciparum	NN
cord-006139-9063uhox	290	74	Dual	dual	JJ
cord-006139-9063uhox	290	75	-	-	HYPH
cord-006139-9063uhox	290	76	functioning	function	VBG
cord-006139-9063uhox	290	77	antimalarials	antimalarial	NNS
cord-006139-9063uhox	290	78	that	that	WDT
cord-006139-9063uhox	290	79	inhibit	inhibit	VBP
cord-006139-9063uhox	290	80	the	the	DT
cord-006139-9063uhox	290	81	chloroquine	chloroquine	NN
cord-006139-9063uhox	290	82	-	-	HYPH
cord-006139-9063uhox	290	83	resistance	resistance	NN
cord-006139-9063uhox	290	84	transporter	transporter	NN
cord-006139-9063uhox	290	85	Purified	purify	VBN
cord-006139-9063uhox	290	86	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	290	87	falciparum	falciparum	NN
cord-006139-9063uhox	290	88	multi	multi	JJ
cord-006139-9063uhox	290	89	-	-	JJ
cord-006139-9063uhox	290	90	drug	drug	JJ
cord-006139-9063uhox	290	91	resistance	resistance	NN
cord-006139-9063uhox	290	92	protein	protein	NN
cord-006139-9063uhox	290	93	(	(	-LRB-
cord-006139-9063uhox	290	94	PfMDR	pfmdr	NN
cord-006139-9063uhox	290	95	1	1	CD
cord-006139-9063uhox	290	96	)	)	-RRB-
cord-006139-9063uhox	290	97	binds	bind	VBZ
cord-006139-9063uhox	290	98	a	a	DT
cord-006139-9063uhox	290	99	high	high	JJ
cord-006139-9063uhox	290	100	affinity	affinity	NN
cord-006139-9063uhox	290	101	chloroquine	chloroquine	NN
cord-006139-9063uhox	290	102	analogue	analogue	NN
cord-006139-9063uhox	290	103	Genetic	genetic	JJ
cord-006139-9063uhox	290	104	linkage	linkage	NN
cord-006139-9063uhox	290	105	analyses	analysis	NNS
cord-006139-9063uhox	290	106	redefine	redefine	VBP
cord-006139-9063uhox	290	107	the	the	DT
cord-006139-9063uhox	290	108	roles	role	NNS
cord-006139-9063uhox	290	109	of	of	IN
cord-006139-9063uhox	290	110	PfCRT	PfCRT	NNP
cord-006139-9063uhox	290	111	and	and	CC
cord-006139-9063uhox	290	112	PfMDR1	pfmdr1	NN
cord-006139-9063uhox	290	113	in	in	IN
cord-006139-9063uhox	290	114	drug	drug	NN
cord-006139-9063uhox	290	115	accumulation	accumulation	NN
cord-006139-9063uhox	290	116	and	and	CC
cord-006139-9063uhox	290	117	susceptibility	susceptibility	NN
cord-006139-9063uhox	290	118	in	in	IN
cord-006139-9063uhox	290	119	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	290	120	falciparum	falciparum	NN
cord-006139-9063uhox	290	121	Multiple	multiple	JJ
cord-006139-9063uhox	290	122	transporters	transporter	NNS
cord-006139-9063uhox	290	123	associated	associate	VBN
cord-006139-9063uhox	290	124	with	with	IN
cord-006139-9063uhox	290	125	malaria	malaria	NN
cord-006139-9063uhox	290	126	parasite	parasite	NN
cord-006139-9063uhox	290	127	responses	response	NNS
cord-006139-9063uhox	290	128	to	to	IN
cord-006139-9063uhox	290	129	chloroquine	chloroquine	NN
cord-006139-9063uhox	290	130	and	and	CC
cord-006139-9063uhox	290	131	quinine	quinine	NN
cord-006139-9063uhox	290	132	Disruption	disruption	NN
cord-006139-9063uhox	290	133	of	of	IN
cord-006139-9063uhox	290	134	a	a	DT
cord-006139-9063uhox	290	135	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	290	136	falciparum	falciparum	NN
cord-006139-9063uhox	290	137	multidrug	multidrug	NN
cord-006139-9063uhox	290	138	resistance	resistance	NN
cord-006139-9063uhox	290	139	-	-	HYPH
cord-006139-9063uhox	290	140	associated	associate	VBN
cord-006139-9063uhox	290	141	protein	protein	NN
cord-006139-9063uhox	290	142	(	(	-LRB-
cord-006139-9063uhox	290	143	PfMRP	pfmrp	NN
cord-006139-9063uhox	290	144	)	)	-RRB-
cord-006139-9063uhox	290	145	alters	alter	VBZ
cord-006139-9063uhox	290	146	its	-PRON-	PRP$
cord-006139-9063uhox	290	147	fitness	fitness	NN
cord-006139-9063uhox	290	148	and	and	CC
cord-006139-9063uhox	290	149	transport	transport	NN
cord-006139-9063uhox	290	150	of	of	IN
cord-006139-9063uhox	290	151	antimalarial	antimalarial	JJ
cord-006139-9063uhox	290	152	drugs	drug	NNS
cord-006139-9063uhox	290	153	and	and	CC
cord-006139-9063uhox	290	154	glutathione	glutathione	NN
cord-006139-9063uhox	291	1	The	the	DT
cord-006139-9063uhox	291	2	malaria	malaria	NN
cord-006139-9063uhox	291	3	parasite	parasite	NN
cord-006139-9063uhox	291	4	's	's	POS
cord-006139-9063uhox	291	5	chloroquine	chloroquine	NN
cord-006139-9063uhox	291	6	resistance	resistance	NN
cord-006139-9063uhox	291	7	transporter	transporter	NN
cord-006139-9063uhox	291	8	is	be	VBZ
cord-006139-9063uhox	291	9	a	a	DT
cord-006139-9063uhox	291	10	member	member	NN
cord-006139-9063uhox	291	11	of	of	IN
cord-006139-9063uhox	291	12	the	the	DT
cord-006139-9063uhox	291	13	drug	drug	NN
cord-006139-9063uhox	291	14	/	/	SYM
cord-006139-9063uhox	291	15	metabolite	metabolite	NN
cord-006139-9063uhox	291	16	transporter	transporter	NN
cord-006139-9063uhox	291	17	superfamily	superfamily	NN
cord-006139-9063uhox	292	1	Know	know	VB
cord-006139-9063uhox	292	2	your	-PRON-	PRP$
cord-006139-9063uhox	292	3	enemy	enemy	NN
cord-006139-9063uhox	292	4	:	:	:
cord-006139-9063uhox	293	1	understanding	understand	VBG
cord-006139-9063uhox	293	2	the	the	DT
cord-006139-9063uhox	293	3	role	role	NN
cord-006139-9063uhox	293	4	of	of	IN
cord-006139-9063uhox	293	5	PfCRT	PfCRT	NNP
cord-006139-9063uhox	293	6	in	in	IN
cord-006139-9063uhox	293	7	drug	drug	NN
cord-006139-9063uhox	293	8	resistance	resistance	NN
cord-006139-9063uhox	293	9	could	could	MD
cord-006139-9063uhox	293	10	lead	lead	VB
cord-006139-9063uhox	293	11	to	to	IN
cord-006139-9063uhox	293	12	new	new	JJ
cord-006139-9063uhox	293	13	antimalarial	antimalarial	JJ
cord-006139-9063uhox	293	14	tactics	tactic	NNS
cord-006139-9063uhox	293	15	pfcrt	pfcrt	NNP
cord-006139-9063uhox	293	16	is	be	VBZ
cord-006139-9063uhox	293	17	more	more	JJR
cord-006139-9063uhox	293	18	than	than	IN
cord-006139-9063uhox	293	19	the	the	DT
cord-006139-9063uhox	293	20	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	293	21	falciparum	falciparum	NN
cord-006139-9063uhox	293	22	chloroquine	chloroquine	NN
cord-006139-9063uhox	293	23	resistance	resistance	NN
cord-006139-9063uhox	293	24	gene	gene	NN
cord-006139-9063uhox	293	25	:	:	:
cord-006139-9063uhox	293	26	a	a	DT
cord-006139-9063uhox	293	27	functional	functional	JJ
cord-006139-9063uhox	293	28	and	and	CC
cord-006139-9063uhox	293	29	evolutionary	evolutionary	JJ
cord-006139-9063uhox	293	30	perspective	perspective	NN
cord-006139-9063uhox	294	1	Chloroquine	chloroquine	JJ
cord-006139-9063uhox	294	2	transport	transport	NN
cord-006139-9063uhox	294	3	via	via	IN
cord-006139-9063uhox	294	4	the	the	DT
cord-006139-9063uhox	294	5	malaria	malaria	NN
cord-006139-9063uhox	294	6	parasite	parasite	NN
cord-006139-9063uhox	294	7	's	's	POS
cord-006139-9063uhox	294	8	chloroquine	chloroquine	NN
cord-006139-9063uhox	294	9	resistance	resistance	NN
cord-006139-9063uhox	294	10	transporter	transporter	NN
cord-006139-9063uhox	294	11	Photoaffinity	Photoaffinity	NNP
cord-006139-9063uhox	294	12	labeling	labeling	NN
cord-006139-9063uhox	294	13	of	of	IN
cord-006139-9063uhox	294	14	the	the	DT
cord-006139-9063uhox	294	15	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	294	16	falciparum	falciparum	NN
cord-006139-9063uhox	294	17	chloroquine	chloroquine	NN
cord-006139-9063uhox	294	18	resistance	resistance	NN
cord-006139-9063uhox	294	19	transporter	transporter	NN
cord-006139-9063uhox	294	20	with	with	IN
cord-006139-9063uhox	294	21	a	a	DT
cord-006139-9063uhox	294	22	novel	novel	JJ
cord-006139-9063uhox	294	23	perfluorophenylazido	perfluorophenylazido	NN
cord-006139-9063uhox	294	24	chloroquine	chloroquine	NN
cord-006139-9063uhox	294	25	Drugresistant	Drugresistant	NNP
cord-006139-9063uhox	294	26	malaria	malaria	NN
cord-006139-9063uhox	294	27	:	:	:
cord-006139-9063uhox	294	28	molecular	molecular	JJ
cord-006139-9063uhox	294	29	mechanisms	mechanism	NNS
cord-006139-9063uhox	294	30	and	and	CC
cord-006139-9063uhox	294	31	implications	implication	NNS
cord-006139-9063uhox	294	32	for	for	IN
cord-006139-9063uhox	294	33	public	public	JJ
cord-006139-9063uhox	294	34	health	health	NN
cord-006139-9063uhox	294	35	PfCRT	PfCRT	NNPS
cord-006139-9063uhox	294	36	and	and	CC
cord-006139-9063uhox	294	37	its	-PRON-	PRP$
cord-006139-9063uhox	294	38	role	role	NN
cord-006139-9063uhox	294	39	in	in	IN
cord-006139-9063uhox	294	40	antimalarial	antimalarial	JJ
cord-006139-9063uhox	294	41	drug	drug	NN
cord-006139-9063uhox	294	42	resistance	resistance	NN
cord-006139-9063uhox	294	43	PfCRT	PfCRT	NNP
cord-006139-9063uhox	294	44	-	-	HYPH
cord-006139-9063uhox	294	45	mediated	mediate	VBN
cord-006139-9063uhox	294	46	drug	drug	NN
cord-006139-9063uhox	294	47	transport	transport	NN
cord-006139-9063uhox	294	48	in	in	IN
cord-006139-9063uhox	294	49	malarial	malarial	JJ
cord-006139-9063uhox	294	50	parasites	parasite	NNS
cord-006139-9063uhox	294	51	Efflux	Efflux	NNP
cord-006139-9063uhox	294	52	of	of	IN
cord-006139-9063uhox	294	53	chloroquine	chloroquine	NN
cord-006139-9063uhox	294	54	from	from	IN
cord-006139-9063uhox	294	55	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	294	56	falciparum	falciparum	NNS
cord-006139-9063uhox	294	57	:	:	:
cord-006139-9063uhox	294	58	mechanism	mechanism	NN
cord-006139-9063uhox	294	59	of	of	IN
cord-006139-9063uhox	294	60	chloroquine	chloroquine	NN
cord-006139-9063uhox	294	61	resistance	resistance	NN
cord-006139-9063uhox	294	62	Reversal	reversal	NN
cord-006139-9063uhox	294	63	of	of	IN
cord-006139-9063uhox	294	64	chloroquine	chloroquine	NN
cord-006139-9063uhox	294	65	resistance	resistance	NN
cord-006139-9063uhox	294	66	in	in	IN
cord-006139-9063uhox	294	67	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	294	68	falciparum	falciparum	NNS
cord-006139-9063uhox	294	69	by	by	IN
cord-006139-9063uhox	294	70	verapamil	verapamil	NN
cord-006139-9063uhox	294	71	Quinolineresistance	Quinolineresistance	NNP
cord-006139-9063uhox	294	72	reversing	reverse	VBG
cord-006139-9063uhox	294	73	agents	agent	NNS
cord-006139-9063uhox	294	74	for	for	IN
cord-006139-9063uhox	294	75	the	the	DT
cord-006139-9063uhox	294	76	malaria	malaria	NN
cord-006139-9063uhox	294	77	parasite	parasite	NN
cord-006139-9063uhox	294	78	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	294	79	falciparum	falciparum	NN
cord-006139-9063uhox	294	80	.	.	.
cord-006139-9063uhox	295	1	Drug	Drug	NNP
cord-006139-9063uhox	295	2	Resist	Resist	NNP
cord-006139-9063uhox	295	3	A	a	DT
cord-006139-9063uhox	295	4	series	series	NN
cord-006139-9063uhox	295	5	of	of	IN
cord-006139-9063uhox	295	6	structurally	structurally	RB
cord-006139-9063uhox	295	7	simple	simple	JJ
cord-006139-9063uhox	295	8	chloroquine	chloroquine	NN
cord-006139-9063uhox	295	9	chemosensitizing	chemosensitize	VBG
cord-006139-9063uhox	295	10	dibemethin	dibemethin	NN
cord-006139-9063uhox	295	11	derivatives	derivative	NNS
cord-006139-9063uhox	295	12	that	that	WDT
cord-006139-9063uhox	295	13	inhibit	inhibit	VBP
cord-006139-9063uhox	295	14	chloroquine	chloroquine	NN
cord-006139-9063uhox	295	15	transport	transport	NN
cord-006139-9063uhox	295	16	by	by	IN
cord-006139-9063uhox	295	17	PfCRT	PfCRT	NNP
cord-006139-9063uhox	295	18	Synthesis	Synthesis	NNP
cord-006139-9063uhox	295	19	and	and	CC
cord-006139-9063uhox	295	20	effects	effect	NNS
cord-006139-9063uhox	295	21	on	on	IN
cord-006139-9063uhox	295	22	chloroquine	chloroquine	NN
cord-006139-9063uhox	295	23	susceptibility	susceptibility	NN
cord-006139-9063uhox	295	24	in	in	IN
cord-006139-9063uhox	295	25	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	295	26	falciparum	falciparum	NNS
cord-006139-9063uhox	295	27	of	of	IN
cord-006139-9063uhox	295	28	a	a	DT
cord-006139-9063uhox	295	29	series	series	NN
cord-006139-9063uhox	295	30	of	of	IN
cord-006139-9063uhox	295	31	new	new	JJ
cord-006139-9063uhox	295	32	dihydroanthracene	dihydroanthracene	NNP
cord-006139-9063uhox	295	33	derivatives	derivative	NNS
cord-006139-9063uhox	295	34	A	a	DT
cord-006139-9063uhox	295	35	3D	3d	JJ
cord-006139-9063uhox	295	36	QSAR	QSAR	NNP
cord-006139-9063uhox	295	37	pharmacophore	pharmacophore	NN
cord-006139-9063uhox	295	38	model	model	NN
cord-006139-9063uhox	295	39	and	and	CC
cord-006139-9063uhox	295	40	quantum	quantum	JJ
cord-006139-9063uhox	295	41	chemical	chemical	NN
cord-006139-9063uhox	295	42	structureactivity	structureactivity	NN
cord-006139-9063uhox	295	43	analysis	analysis	NN
cord-006139-9063uhox	295	44	of	of	IN
cord-006139-9063uhox	295	45	chloroquine(CQ)-resistance	chloroquine(cq)-resistance	NN
cord-006139-9063uhox	295	46	reversal	reversal	NN
cord-006139-9063uhox	296	1	A	a	DT
cord-006139-9063uhox	296	2	chloroquine	chloroquine	NN
cord-006139-9063uhox	296	3	-	-	HYPH
cord-006139-9063uhox	296	4	like	like	JJ
cord-006139-9063uhox	296	5	molecule	molecule	NN
cord-006139-9063uhox	296	6	designed	design	VBN
cord-006139-9063uhox	296	7	to	to	TO
cord-006139-9063uhox	296	8	reverse	reverse	VB
cord-006139-9063uhox	296	9	resistance	resistance	NN
cord-006139-9063uhox	296	10	in	in	IN
cord-006139-9063uhox	296	11	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	296	12	falciparum	falciparum	NN
cord-006139-9063uhox	296	13	Reversal	reversal	NN
cord-006139-9063uhox	296	14	agent	agent	NN
cord-006139-9063uhox	296	15	and	and	CC
cord-006139-9063uhox	296	16	linker	linker	NN
cord-006139-9063uhox	296	17	variants	variant	NNS
cord-006139-9063uhox	296	18	of	of	IN
cord-006139-9063uhox	296	19	reversed	reverse	VBN
cord-006139-9063uhox	296	20	chloroquines	chloroquine	NNS
cord-006139-9063uhox	296	21	:	:	:
cord-006139-9063uhox	296	22	activities	activity	NNS
cord-006139-9063uhox	296	23	against	against	IN
cord-006139-9063uhox	296	24	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	296	25	falciparum	falciparum	NN
cord-006139-9063uhox	296	26	Synthesis	Synthesis	NNP
cord-006139-9063uhox	296	27	,	,	,
cord-006139-9063uhox	296	28	structure	structure	NN
cord-006139-9063uhox	296	29	-	-	HYPH
cord-006139-9063uhox	296	30	activity	activity	NN
cord-006139-9063uhox	296	31	relationship	relationship	NN
cord-006139-9063uhox	296	32	,	,	,
cord-006139-9063uhox	296	33	and	and	CC
cord-006139-9063uhox	296	34	mode	mode	NN
cord-006139-9063uhox	296	35	-	-	HYPH
cord-006139-9063uhox	296	36	of	of	IN
cord-006139-9063uhox	296	37	-	-	HYPH
cord-006139-9063uhox	296	38	action	action	NN
cord-006139-9063uhox	296	39	studies	study	NNS
cord-006139-9063uhox	296	40	of	of	IN
cord-006139-9063uhox	296	41	antimalarial	antimalarial	JJ
cord-006139-9063uhox	296	42	reversed	reverse	VBN
cord-006139-9063uhox	296	43	chloroquine	chloroquine	NN
cord-006139-9063uhox	296	44	compounds	compound	NNS
cord-006139-9063uhox	296	45	Reversed	reverse	VBD
cord-006139-9063uhox	296	46	chloroquines	chloroquine	NNS
cord-006139-9063uhox	296	47	based	base	VBN
cord-006139-9063uhox	296	48	on	on	IN
cord-006139-9063uhox	296	49	the	the	DT
cord-006139-9063uhox	296	50	3,4-dihydropyrimidin-2	3,4-dihydropyrimidin-2	NNS
cord-006139-9063uhox	296	51	(	(	-LRB-
cord-006139-9063uhox	296	52	1	1	CD
cord-006139-9063uhox	296	53	H)-one	H)-one	NNP
cord-006139-9063uhox	296	54	scaffold	scaffold	NN
cord-006139-9063uhox	296	55	:	:	:
cord-006139-9063uhox	296	56	synthesis	synthesis	NN
cord-006139-9063uhox	296	57	and	and	CC
cord-006139-9063uhox	296	58	evaluation	evaluation	NN
cord-006139-9063uhox	296	59	for	for	IN
cord-006139-9063uhox	296	60	antimalarial	antimalarial	JJ
cord-006139-9063uhox	296	61	,	,	,
cord-006139-9063uhox	296	62	beta	beta	NN
cord-006139-9063uhox	296	63	-	-	HYPH
cord-006139-9063uhox	296	64	haematin	haematin	NN
cord-006139-9063uhox	296	65	inhibition	inhibition	NN
cord-006139-9063uhox	296	66	,	,	,
cord-006139-9063uhox	296	67	and	and	CC
cord-006139-9063uhox	296	68	cytotoxic	cytotoxic	JJ
cord-006139-9063uhox	296	69	activity	activity	NN
cord-006139-9063uhox	296	70	Design	design	NN
cord-006139-9063uhox	296	71	,	,	,
cord-006139-9063uhox	296	72	synthesis	synthesis	NN
cord-006139-9063uhox	296	73	,	,	,
cord-006139-9063uhox	296	74	and	and	CC
cord-006139-9063uhox	296	75	evaluation	evaluation	NN
cord-006139-9063uhox	296	76	of	of	IN
cord-006139-9063uhox	296	77	10-N	10-n	CD
cord-006139-9063uhox	296	78	-	-	HYPH
cord-006139-9063uhox	296	79	substituted	substitute	VBN
cord-006139-9063uhox	296	80	acridones	acridone	NNS
cord-006139-9063uhox	296	81	as	as	IN
cord-006139-9063uhox	296	82	novel	novel	JJ
cord-006139-9063uhox	296	83	chemosensitizers	chemosensitizer	NNS
cord-006139-9063uhox	296	84	in	in	IN
cord-006139-9063uhox	296	85	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	296	86	falciparum	falciparum	NNP
cord-006139-9063uhox	296	87	Discovery	Discovery	NNP
cord-006139-9063uhox	296	88	of	of	IN
cord-006139-9063uhox	296	89	dual	dual	JJ
cord-006139-9063uhox	296	90	function	function	NN
cord-006139-9063uhox	296	91	acridones	acridone	NNS
cord-006139-9063uhox	296	92	as	as	IN
cord-006139-9063uhox	296	93	a	a	DT
cord-006139-9063uhox	296	94	new	new	JJ
cord-006139-9063uhox	296	95	antimalarial	antimalarial	JJ
cord-006139-9063uhox	296	96	chemotype	chemotype	NN
cord-006139-9063uhox	296	97	n	n	CC
cord-006139-9063uhox	296	98	First	first	JJ
cord-006139-9063uhox	296	99	example	example	NN
cord-006139-9063uhox	296	100	of	of	IN
cord-006139-9063uhox	296	101	a	a	DT
cord-006139-9063uhox	296	102	dual	dual	JJ
cord-006139-9063uhox	296	103	-	-	HYPH
cord-006139-9063uhox	296	104	functional	functional	JJ
cord-006139-9063uhox	296	105	acridone	acridone	NN
cord-006139-9063uhox	296	106	that	that	WDT
cord-006139-9063uhox	296	107	inhibits	inhibit	VBZ
cord-006139-9063uhox	296	108	parasite	parasite	JJ
cord-006139-9063uhox	296	109	growth	growth	NN
cord-006139-9063uhox	296	110	and	and	CC
cord-006139-9063uhox	297	1	PfCRT	PfCRT	NNP
cord-006139-9063uhox	297	2	in	in	IN
cord-006139-9063uhox	297	3	chloroquine	chloroquine	NN
cord-006139-9063uhox	297	4	-	-	HYPH
cord-006139-9063uhox	297	5	resistant	resistant	JJ
cord-006139-9063uhox	297	6	parasites	parasite	NNS
cord-006139-9063uhox	297	7	Quinoline	Quinoline	NNP
cord-006139-9063uhox	297	8	antimalarials	antimalarial	NNS
cord-006139-9063uhox	297	9	containing	contain	VBG
cord-006139-9063uhox	297	10	a	a	DT
cord-006139-9063uhox	297	11	dibemethin	dibemethin	NN
cord-006139-9063uhox	297	12	group	group	NN
cord-006139-9063uhox	297	13	are	be	VBP
cord-006139-9063uhox	297	14	active	active	JJ
cord-006139-9063uhox	297	15	against	against	IN
cord-006139-9063uhox	297	16	chloroquinone	chloroquinone	NN
cord-006139-9063uhox	297	17	-	-	HYPH
cord-006139-9063uhox	297	18	resistant	resistant	JJ
cord-006139-9063uhox	297	19	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	297	20	falciparum	falciparum	NNS
cord-006139-9063uhox	297	21	and	and	CC
cord-006139-9063uhox	297	22	inhibit	inhibit	VB
cord-006139-9063uhox	297	23	chloroquine	chloroquine	NN
cord-006139-9063uhox	297	24	transport	transport	NN
cord-006139-9063uhox	297	25	via	via	IN
cord-006139-9063uhox	297	26	the	the	DT
cord-006139-9063uhox	297	27	P.	P.	NNP
cord-006139-9063uhox	297	28	falciparum	falciparum	NN
cord-006139-9063uhox	297	29	chloroquine	chloroquine	NN
cord-006139-9063uhox	297	30	-	-	HYPH
cord-006139-9063uhox	297	31	resistance	resistance	NN
cord-006139-9063uhox	297	32	transporter	transporter	NN
cord-006139-9063uhox	297	33	(	(	-LRB-
cord-006139-9063uhox	298	1	PfCRT	PfCRT	NNP
cord-006139-9063uhox	298	2	)	)	-RRB-
cord-006139-9063uhox	298	3	nn	nn	XX
cord-006139-9063uhox	299	1	First	first	JJ
cord-006139-9063uhox	299	2	example	example	NN
cord-006139-9063uhox	299	3	of	of	IN
cord-006139-9063uhox	299	4	a	a	DT
cord-006139-9063uhox	299	5	dual	dual	JJ
cord-006139-9063uhox	299	6	-	-	HYPH
cord-006139-9063uhox	299	7	functional	functional	JJ
cord-006139-9063uhox	299	8	antimalarial	antimalarial	JJ
cord-006139-9063uhox	299	9	and	and	CC
cord-006139-9063uhox	299	10	chloroquine	chloroquine	NNP
cord-006139-9063uhox	299	11	chemosensitizer	chemosensitizer	NNP
cord-006139-9063uhox	299	12	directly	directly	RB
cord-006139-9063uhox	299	13	demonstrated	demonstrate	VBD
cord-006139-9063uhox	299	14	to	to	TO
cord-006139-9063uhox	299	15	inhibit	inhibit	VB
cord-006139-9063uhox	299	16	chloroquine	chloroquine	NN
cord-006139-9063uhox	299	17	transport	transport	NN
cord-006139-9063uhox	299	18	by	by	IN
cord-006139-9063uhox	299	19	PfCRT	PfCRT	NNP
cord-006139-9063uhox	299	20	Reversed	reverse	VBN
cord-006139-9063uhox	299	21	chloroquine	chloroquine	NN
cord-006139-9063uhox	299	22	molecules	molecule	NNS
cord-006139-9063uhox	299	23	as	as	IN
cord-006139-9063uhox	299	24	a	a	DT
cord-006139-9063uhox	299	25	strategy	strategy	NN
cord-006139-9063uhox	299	26	to	to	TO
cord-006139-9063uhox	299	27	overcome	overcome	VB
cord-006139-9063uhox	299	28	resistance	resistance	NN
cord-006139-9063uhox	299	29	in	in	IN
cord-006139-9063uhox	299	30	malaria	malaria	NN
cord-006139-9063uhox	299	31	Long	long	JJ
cord-006139-9063uhox	299	32	QT	QT	NNP
cord-006139-9063uhox	299	33	syndromes	syndrome	NNS
cord-006139-9063uhox	299	34	and	and	CC
cord-006139-9063uhox	299	35	torsade	torsade	NNP
cord-006139-9063uhox	299	36	de	de	FW
cord-006139-9063uhox	299	37	pointes	pointes	NNP
cord-006139-9063uhox	299	38	Fatal	fatal	JJ
cord-006139-9063uhox	299	39	cardiotoxicity	cardiotoxicity	NN
cord-006139-9063uhox	299	40	related	relate	VBN
cord-006139-9063uhox	299	41	to	to	IN
cord-006139-9063uhox	299	42	halofantrine	halofantrine	NNP
cord-006139-9063uhox	299	43	:	:	:
cord-006139-9063uhox	299	44	a	a	DT
cord-006139-9063uhox	299	45	review	review	NN
cord-006139-9063uhox	299	46	based	base	VBN
cord-006139-9063uhox	299	47	on	on	IN
cord-006139-9063uhox	299	48	a	a	DT
cord-006139-9063uhox	299	49	worldwide	worldwide	JJ
cord-006139-9063uhox	299	50	safety	safety	NN
cord-006139-9063uhox	299	51	data	datum	NNS
cord-006139-9063uhox	299	52	base	base	NN
cord-006139-9063uhox	299	53	Generation	Generation	NNP
cord-006139-9063uhox	299	54	of	of	IN
cord-006139-9063uhox	299	55	a	a	DT
cord-006139-9063uhox	299	56	set	set	NN
cord-006139-9063uhox	299	57	of	of	IN
cord-006139-9063uhox	299	58	simple	simple	JJ
cord-006139-9063uhox	299	59	,	,	,
cord-006139-9063uhox	299	60	interpretable	interpretable	JJ
cord-006139-9063uhox	299	61	ADMET	admet	JJ
cord-006139-9063uhox	299	62	rules	rule	NNS
cord-006139-9063uhox	299	63	of	of	IN
cord-006139-9063uhox	299	64	thumb	thumb	NN
cord-006139-9063uhox	300	1	The	the	DT
cord-006139-9063uhox	300	2	pH	ph	NN
cord-006139-9063uhox	300	3	of	of	IN
cord-006139-9063uhox	300	4	the	the	DT
cord-006139-9063uhox	300	5	digestive	digestive	JJ
cord-006139-9063uhox	300	6	vacuole	vacuole	NN
cord-006139-9063uhox	300	7	of	of	IN
cord-006139-9063uhox	300	8	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	300	9	falciparum	falciparum	NN
cord-006139-9063uhox	300	10	is	be	VBZ
cord-006139-9063uhox	300	11	not	not	RB
cord-006139-9063uhox	300	12	associated	associate	VBN
cord-006139-9063uhox	300	13	with	with	IN
cord-006139-9063uhox	300	14	chloroquine	chloroquine	NN
cord-006139-9063uhox	300	15	resistance	resistance	NN
cord-006139-9063uhox	301	1	Four	four	CD
cord-006139-9063uhox	301	2	plasmepsins	plasmepsin	NNS
cord-006139-9063uhox	301	3	are	be	VBP
cord-006139-9063uhox	301	4	active	active	JJ
cord-006139-9063uhox	301	5	in	in	IN
cord-006139-9063uhox	301	6	the	the	DT
cord-006139-9063uhox	301	7	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	301	8	falciparum	falciparum	NN
cord-006139-9063uhox	301	9	food	food	NN
cord-006139-9063uhox	301	10	vacuole	vacuole	NN
cord-006139-9063uhox	301	11	,	,	,
cord-006139-9063uhox	301	12	including	include	VBG
cord-006139-9063uhox	301	13	a	a	DT
cord-006139-9063uhox	301	14	protease	protease	NN
cord-006139-9063uhox	301	15	with	with	IN
cord-006139-9063uhox	301	16	an	an	DT
cord-006139-9063uhox	301	17	activesite	activesite	JJ
cord-006139-9063uhox	301	18	histidine	histidine	NN
cord-006139-9063uhox	301	19	Falcipains	Falcipains	NNP
cord-006139-9063uhox	301	20	and	and	CC
cord-006139-9063uhox	301	21	other	other	JJ
cord-006139-9063uhox	301	22	cysteine	cysteine	NN
cord-006139-9063uhox	301	23	proteases	protease	NNS
cord-006139-9063uhox	301	24	of	of	IN
cord-006139-9063uhox	301	25	malaria	malaria	NN
cord-006139-9063uhox	301	26	parasites	parasite	NNS
cord-006139-9063uhox	301	27	Identification	identification	NN
cord-006139-9063uhox	301	28	and	and	CC
cord-006139-9063uhox	301	29	characterization	characterization	NN
cord-006139-9063uhox	301	30	of	of	IN
cord-006139-9063uhox	301	31	falcilysin	falcilysin	NNP
cord-006139-9063uhox	301	32	,	,	,
cord-006139-9063uhox	301	33	a	a	DT
cord-006139-9063uhox	301	34	metallopeptidase	metallopeptidase	NN
cord-006139-9063uhox	301	35	involved	involve	VBN
cord-006139-9063uhox	301	36	in	in	IN
cord-006139-9063uhox	301	37	haemoglobin	haemoglobin	NN
cord-006139-9063uhox	301	38	catabolism	catabolism	NN
cord-006139-9063uhox	301	39	within	within	IN
cord-006139-9063uhox	301	40	the	the	DT
cord-006139-9063uhox	301	41	malaria	malaria	NN
cord-006139-9063uhox	301	42	parasite	parasite	NN
cord-006139-9063uhox	301	43	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	301	44	falciparum	falciparum	NN
cord-006139-9063uhox	301	45	Characterization	characterization	NN
cord-006139-9063uhox	301	46	of	of	IN
cord-006139-9063uhox	301	47	the	the	DT
cord-006139-9063uhox	301	48	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	301	49	falciparum	falciparum	NN
cord-006139-9063uhox	301	50	M17	m17	JJ
cord-006139-9063uhox	301	51	leucyl	leucyl	NN
cord-006139-9063uhox	301	52	aminopeptidase	aminopeptidase	NN
cord-006139-9063uhox	301	53	Roles	Roles	NNP
cord-006139-9063uhox	301	54	for	for	IN
cord-006139-9063uhox	301	55	two	two	CD
cord-006139-9063uhox	301	56	aminopeptidases	aminopeptidase	NNS
cord-006139-9063uhox	301	57	in	in	IN
cord-006139-9063uhox	301	58	vacuolar	vacuolar	JJ
cord-006139-9063uhox	301	59	hemoglobin	hemoglobin	NN
cord-006139-9063uhox	301	60	catabolism	catabolism	NN
cord-006139-9063uhox	301	61	in	in	IN
cord-006139-9063uhox	301	62	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	301	63	falciparum	falciparum	NN
cord-006139-9063uhox	301	64	Distribution	distribution	NN
cord-006139-9063uhox	301	65	and	and	CC
cord-006139-9063uhox	301	66	biochemical	biochemical	JJ
cord-006139-9063uhox	301	67	properties	property	NNS
cord-006139-9063uhox	301	68	of	of	IN
cord-006139-9063uhox	301	69	an	an	DT
cord-006139-9063uhox	301	70	M1-family	m1-family	JJ
cord-006139-9063uhox	301	71	aminopeptidase	aminopeptidase	NN
cord-006139-9063uhox	301	72	in	in	IN
cord-006139-9063uhox	301	73	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	301	74	falciparum	falciparum	NNS
cord-006139-9063uhox	301	75	indicate	indicate	VBP
cord-006139-9063uhox	301	76	a	a	DT
cord-006139-9063uhox	301	77	role	role	NN
cord-006139-9063uhox	301	78	in	in	IN
cord-006139-9063uhox	301	79	vacuolar	vacuolar	JJ
cord-006139-9063uhox	301	80	hemoglobin	hemoglobin	NN
cord-006139-9063uhox	301	81	catabolism	catabolism	NN
cord-006139-9063uhox	301	82	Haemozoin	Haemozoin	NNP
cord-006139-9063uhox	301	83	(	(	-LRB-
cord-006139-9063uhox	301	84	b	b	NNP
cord-006139-9063uhox	301	85	-	-	:
cord-006139-9063uhox	301	86	haematin	haematin	NNP
cord-006139-9063uhox	301	87	)	)	-RRB-
cord-006139-9063uhox	301	88	biomineralization	biomineralization	NN
cord-006139-9063uhox	301	89	occurs	occur	VBZ
cord-006139-9063uhox	301	90	by	by	IN
cord-006139-9063uhox	301	91	self	self	NN
cord-006139-9063uhox	301	92	-	-	HYPH
cord-006139-9063uhox	301	93	assembly	assembly	NN
cord-006139-9063uhox	301	94	near	near	IN
cord-006139-9063uhox	301	95	the	the	DT
cord-006139-9063uhox	301	96	lipid	lipid	NN
cord-006139-9063uhox	301	97	/	/	SYM
cord-006139-9063uhox	301	98	water	water	NN
cord-006139-9063uhox	301	99	interface	interface	NN
cord-006139-9063uhox	302	1	The	the	DT
cord-006139-9063uhox	302	2	role	role	NN
cord-006139-9063uhox	302	3	of	of	IN
cord-006139-9063uhox	302	4	neutral	neutral	JJ
cord-006139-9063uhox	302	5	lipid	lipid	NN
cord-006139-9063uhox	302	6	nanospheres	nanosphere	NNS
cord-006139-9063uhox	302	7	in	in	IN
cord-006139-9063uhox	302	8	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	302	9	falciparum	falciparum	NN
cord-006139-9063uhox	302	10	haem	haem	NN
cord-006139-9063uhox	302	11	crystallization	crystallization	NN
cord-006139-9063uhox	303	1	On	on	IN
cord-006139-9063uhox	303	2	the	the	DT
cord-006139-9063uhox	303	3	mechanism	mechanism	NN
cord-006139-9063uhox	303	4	of	of	IN
cord-006139-9063uhox	303	5	chloroquine	chloroquine	NN
cord-006139-9063uhox	303	6	resistance	resistance	NN
cord-006139-9063uhox	303	7	in	in	IN
cord-006139-9063uhox	303	8	Plasmodium	Plasmodium	NNP
cord-006139-9063uhox	303	9	falciparum	falciparum	NN