id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-352844-wggg3ynb	Annunziata, Francesca	An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities	2020-06-29		.txt	text/plain	50752	2326	42	Again, the coumarin derivative showed inhibitory activity on 15-LOX-1 in PC3 and DU145 cell lines, thus inducing apoptosis of the cancer cell, with the same mechanism of The results represent a good starting point for the design of novel derivatives, because most of the examined compounds exhibited selective toxicity on HeLa cells (IC 50 values between 136.4 ± 1.90 µM and 172.2 ± 1.80 µM after 24 h), whereas no negative effects on HDF normal cell's growth was detected. Since tacrine is a well-known inhibitor of the catalytic site of AChE, whereas coumarins showed affinity for the peripheral anionic site (PAS) [161] , this new compounds may be potential dual-and therefore more powerful -inhibitors of ChEs. The in vitro AChE and BuChE inhibitory activity was evaluated using the Ellman's method [159] ; among all the tested molecules, compound 105 resulted the best in AChE inhibition (IC 50 Thanks to their simple structural architecture and chemical stability, coumarins can be easily synthesized and modified in order to produce more active and selective compounds.	./cache/cord-352844-wggg3ynb.txt	./txt/cord-352844-wggg3ynb.txt