id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328962-1c4vqaqr	Benítez-Cardoza, Claudia Guadalupe	Potential inhibitors of the interaction between ACE2 and SARS-CoV-2 (RBD), to develop a drug	2020-06-15		.txt	text/plain	3344	184	54	KEY FINDINGS: 20 best compounds directed to interact in ACE2 with a high probability to be safe in humans, validated by web servers of prediction of ADME and toxicity (ProTox-II and PreADMET), to difficult the interaction between ACE2 and region binding domain (RBD) of SARS-CoV-2. We use the amino acids reported in the crystallographic structure of the interaction between the S-protein-RBD of SARS-CoV-2 and ACE2 (Gln24, Asp30, His34, Tyr41, Gln42, Met82, Lys353 and Arg357 in ACE2) [10] [22] , therefore, using the crystallographic structure of ACE2 (PDB 1R42), we carried out a Docking directed to these mentioned residues using a library of compounds (EXPRESS-pick Collection from Chembridge Corp.) to select the best compounds, and that these can affect the interaction between ACE2 and SARS-CoV-2, making these results an important contribution to establishing the foundations that allow the development of a drug that optimizes the resolution of this pandemic.	./cache/cord-328962-1c4vqaqr.txt	./txt/cord-328962-1c4vqaqr.txt