id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328834-yetnlb2j	Mohsin, Noor ul Amin	Current Strategies in Development of New Chromone Derivatives with Diversified Pharmacological Activities: A Review	2020-06-15		.txt	text/plain	5675	458	57	Upon in vitro evaluation, compound 10 ( Fig. 3) showed prominent activity (87% growth inhibition) against colon cancer cell line (HCT-116) as compared to fluorouracil (67% inhibition). Derivatives bearing electron withdrawing groups at positions # 5, # 6 and # 7 of chromone scaffold showed better activity. Upon evaluation as anticancer agents by MTT assay, compounds 22 (IC 50 = 1.42 ± 0.13 mM) and 23 (IC 50 = 2.92 ± 0.94 mM) showed prominent in vitro activity versus breast cancer cell line (T47D) as compared to doxorubicin (IC 50 = 0.33 ± 0.05 mM). Incorporation of methyl and ethyl group in the heterocyclic ring showed comparable activity to unsubstituted derivatives [47] . Attachment of methyl group with chromone core also produced less active derivatives [51] . synthesized fluorine-containing chromone and tetrazole hybrid molecules by Ugi-azide reaction [63] These derivatives displayed moderate antimicrobial activity as is evident by compound 51 (MIC = 20 mg/mL) activity versus Pseudomonas aeruginosa (P.	./cache/cord-328834-yetnlb2j.txt	./txt/cord-328834-yetnlb2j.txt