id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-270123-m8utyd1m	Enmozhi, Sukanth Kumar	Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach	2020-05-05		.txt	text/plain	3873	187	49	This paper evaluates the compound Andrographolide from Andrographis paniculata as a potential inhibitor of the main protease of SARS-COV-2 (Mpro) through in silico studies such as molecular docking, target analysis, toxicity prediction and ADME prediction. And upon certain in vitro and some clinical data chloroquine phosphate and hydroxychloroquine sulphate was advised to be the treatment for COVID-19 and enough randomized trials on these compounds to be provided and allowed the administration of the above drugs to be used for emergency (https://www.fda.gov/emergency-use-authori-zation#covidtherapeutics). Though there are many targets are found for the treatment of COVID-19, the main protease (M pro ) of SARS-CoV-2 was chosen due to interest of treating infected patients, to stop the multiplication of virus within the cells, through which M pro was involved in the release of polypeptides which are functional extensive proteolysis and cleavage of the enzyme itself from the sites of genome, pp1a and ppa1ab .	./cache/cord-270123-m8utyd1m.txt	./txt/cord-270123-m8utyd1m.txt