id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-261366-mtcalbo5	da Rosa Guimarães, Tatiana	Anti HSV-1 Activity of Halistanol Sulfate and Halistanol Sulfate C Isolated from Brazilian Marine Sponge Petromica citrina (Demospongiae)	2013-10-29		.txt	text/plain	4824	269	54	The n-butanol fraction (BF) obtained from the crude extract of the marine sponge Petromica citrina, the halistanol-enriched fraction (TSH fraction), and the isolated compounds halistanol sulfate (1) and halistanol sulfate C (2), were evaluated for their inhibitory effects on the replication of the Herpes Simplex Virus type 1 (HSV-1, KOS strain) by the viral plaque number reduction assay. In a previous screening of the anti-infective potential of marine invertebrates and seaweeds [28] , we observed a promising activity for the n-butanol fraction (BF) obtained from the ethanolic crude extract of this sponge that led us to perform this study. As it is important to understand the targets and the mode of action of a potential useful new antiviral agent, a set of experiments was carried out to determine the stages at which the most active samples (TSH fraction and compounds 1 and 2) affect the viral replication cycle.	./cache/cord-261366-mtcalbo5.txt	./txt/cord-261366-mtcalbo5.txt