id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-014863-jyti99xq	Karaküçük-İyidoğan, A.	Synthesis, Biological Evaluation and Ligand Based Pharmacophore Modeling of New Aromatic Thiosemicarbazones as Potential Anticancer Agents	2019-05-15		.txt	text/plain	3517	516	69	Encouraged by these results and aimed at developing effective anticancer agents, we designed two series of thiosemicarbazones by the pharmacophore hybridization method using two or more different pharmacophores in view of prospecting their cytostatic and antiviral activity (Fig. 1) . The synthesized compounds were also evaluated for their cytostatic activity against murine leukemia L1210, human CD 4 + T-lymphocyte CEM and cervix carcinoma HeLa cells (Table 4 ). The results showed that compounds Ia -Ig containing electron-withdrawing group, such as -CN located at the para position of the benzene ring, increased the cytostatic activity, according to the electron-donating group (-SCH 3 ) at the same position of the structure (like compounds Synthesis, Biological Evaluation and Ligand 147 IIa -IIg). It is established that Hb-acceptor (-CN; -SCH 3 ), hydrophobic groups (-N(CH 2 CH 2 Cl) 2 ), and 3D-conformations are responsible for the cytostatic activity of compounds such as Ig and IIg, according to ligand-based pharmacophore modeling.	./cache/cord-014863-jyti99xq.txt	./txt/cord-014863-jyti99xq.txt