id sid tid token lemma pos cord-353298-vr5hnzp8 1 1 key key NN cord-353298-vr5hnzp8 1 2 : : : cord-353298-vr5hnzp8 2 1 cord-353298-vr5hnzp8 cord-353298-vr5hnzp8 NNP cord-353298-vr5hnzp8 2 2 authors author NNS cord-353298-vr5hnzp8 2 3 : : : cord-353298-vr5hnzp8 3 1 nan nan NNP cord-353298-vr5hnzp8 3 2 title title NN cord-353298-vr5hnzp8 3 3 : : : cord-353298-vr5hnzp8 4 1 In in IN cord-353298-vr5hnzp8 4 2 vitro vitro FW cord-353298-vr5hnzp8 4 3 analysis analysis NN cord-353298-vr5hnzp8 4 4 of of IN cord-353298-vr5hnzp8 4 5 the the DT cord-353298-vr5hnzp8 4 6 oligodendrocyte oligodendrocyte NNP cord-353298-vr5hnzp8 4 7 lineage lineage NN cord-353298-vr5hnzp8 4 8 in in IN cord-353298-vr5hnzp8 4 9 mice mouse NNS cord-353298-vr5hnzp8 4 10 during during IN cord-353298-vr5hnzp8 4 11 demyelination demyelination NN cord-353298-vr5hnzp8 4 12 and and CC cord-353298-vr5hnzp8 4 13 remyelination remyelination NN cord-353298-vr5hnzp8 4 14 date date NN cord-353298-vr5hnzp8 4 15 : : : cord-353298-vr5hnzp8 4 16 1990 1990 CD cord-353298-vr5hnzp8 4 17 - - SYM cord-353298-vr5hnzp8 4 18 09 09 CD cord-353298-vr5hnzp8 4 19 - - HYPH cord-353298-vr5hnzp8 4 20 01 01 CD cord-353298-vr5hnzp8 4 21 journal journal NN cord-353298-vr5hnzp8 4 22 : : : cord-353298-vr5hnzp8 4 23 J J NNP cord-353298-vr5hnzp8 4 24 Cell Cell NNP cord-353298-vr5hnzp8 4 25 Biol Biol NNP cord-353298-vr5hnzp8 4 26 DOI DOI NNP cord-353298-vr5hnzp8 4 27 : : : cord-353298-vr5hnzp8 4 28 nan nan NNP cord-353298-vr5hnzp8 4 29 sha sha NNP cord-353298-vr5hnzp8 4 30 : : : cord-353298-vr5hnzp8 4 31 63aed9fa99e7df7846c24993fbf4d7aebb4d957a 63aed9fa99e7df7846c24993fbf4d7aebb4d957a CD cord-353298-vr5hnzp8 4 32 doc_id doc_id CD cord-353298-vr5hnzp8 4 33 : : : cord-353298-vr5hnzp8 4 34 353298 353298 CD cord-353298-vr5hnzp8 4 35 cord_uid cord_uid NN cord-353298-vr5hnzp8 4 36 : : : cord-353298-vr5hnzp8 5 1 vr5hnzp8 vr5hnzp8 NNP cord-353298-vr5hnzp8 5 2 A a DT cord-353298-vr5hnzp8 5 3 demyelinating demyelinating JJ cord-353298-vr5hnzp8 5 4 disease disease NN cord-353298-vr5hnzp8 5 5 induced induce VBN cord-353298-vr5hnzp8 5 6 in in IN cord-353298-vr5hnzp8 5 7 C57B1/6N C57B1/6N NNP cord-353298-vr5hnzp8 5 8 mice mouse NNS cord-353298-vr5hnzp8 5 9 by by IN cord-353298-vr5hnzp8 5 10 intracranial intracranial JJ cord-353298-vr5hnzp8 5 11 injection injection NN cord-353298-vr5hnzp8 5 12 of of IN cord-353298-vr5hnzp8 5 13 a a DT cord-353298-vr5hnzp8 5 14 coronavirus coronavirus NN cord-353298-vr5hnzp8 6 1 ( ( -LRB- cord-353298-vr5hnzp8 6 2 murine murine JJ cord-353298-vr5hnzp8 6 3 hepatitis hepatitis NN cord-353298-vr5hnzp8 6 4 virus virus NN cord-353298-vr5hnzp8 6 5 strain strain NN cord-353298-vr5hnzp8 6 6 A59 A59 NNP cord-353298-vr5hnzp8 6 7 ) ) -RRB- cord-353298-vr5hnzp8 6 8 is be VBZ cord-353298-vr5hnzp8 6 9 followed follow VBN cord-353298-vr5hnzp8 6 10 by by IN cord-353298-vr5hnzp8 6 11 functional functional JJ cord-353298-vr5hnzp8 6 12 recovery recovery NN cord-353298-vr5hnzp8 6 13 and and CC cord-353298-vr5hnzp8 6 14 efficient efficient JJ cord-353298-vr5hnzp8 6 15 CNS CNS NNP cord-353298-vr5hnzp8 6 16 myelin myelin NN cord-353298-vr5hnzp8 6 17 repair repair NN cord-353298-vr5hnzp8 6 18 . . . cord-353298-vr5hnzp8 7 1 To to TO cord-353298-vr5hnzp8 7 2 study study VB cord-353298-vr5hnzp8 7 3 the the DT cord-353298-vr5hnzp8 7 4 biological biological JJ cord-353298-vr5hnzp8 7 5 properties property NNS cord-353298-vr5hnzp8 7 6 of of IN cord-353298-vr5hnzp8 7 7 the the DT cord-353298-vr5hnzp8 7 8 cells cell NNS cord-353298-vr5hnzp8 7 9 involved involve VBN cord-353298-vr5hnzp8 7 10 in in IN cord-353298-vr5hnzp8 7 11 this this DT cord-353298-vr5hnzp8 7 12 repair repair NN cord-353298-vr5hnzp8 7 13 process process NN cord-353298-vr5hnzp8 7 14 , , , cord-353298-vr5hnzp8 7 15 glial glial JJ cord-353298-vr5hnzp8 7 16 cells cell NNS cord-353298-vr5hnzp8 7 17 were be VBD cord-353298-vr5hnzp8 7 18 isolated isolate VBN cord-353298-vr5hnzp8 7 19 and and CC cord-353298-vr5hnzp8 7 20 cultured culture VBN cord-353298-vr5hnzp8 7 21 from from IN cord-353298-vr5hnzp8 7 22 spinal spinal JJ cord-353298-vr5hnzp8 7 23 cords cord NNS cord-353298-vr5hnzp8 7 24 of of IN cord-353298-vr5hnzp8 7 25 these these DT cord-353298-vr5hnzp8 7 26 young young JJ cord-353298-vr5hnzp8 7 27 adult adult NN cord-353298-vr5hnzp8 7 28 mice mouse NNS cord-353298-vr5hnzp8 7 29 during during IN cord-353298-vr5hnzp8 7 30 demyelination demyelination NN cord-353298-vr5hnzp8 7 31 and and CC cord-353298-vr5hnzp8 7 32 remyelination remyelination NN cord-353298-vr5hnzp8 7 33 . . . cord-353298-vr5hnzp8 8 1 Using use VBG cord-353298-vr5hnzp8 8 2 three three CD cord-353298-vr5hnzp8 8 3 - - HYPH cord-353298-vr5hnzp8 8 4 color color NN cord-353298-vr5hnzp8 8 5 immunofluorescence immunofluorescence NN cord-353298-vr5hnzp8 8 6 combined combine VBN cord-353298-vr5hnzp8 8 7 with with IN cord-353298-vr5hnzp8 8 8 [ [ -LRB- cord-353298-vr5hnzp8 8 9 3H]thymidine 3h]thymidine CD cord-353298-vr5hnzp8 8 10 autoradiography autoradiography NNP cord-353298-vr5hnzp8 8 11 , , , cord-353298-vr5hnzp8 8 12 we -PRON- PRP cord-353298-vr5hnzp8 8 13 have have VBP cord-353298-vr5hnzp8 8 14 analyzed analyze VBN cord-353298-vr5hnzp8 8 15 the the DT cord-353298-vr5hnzp8 8 16 antigenic antigenic JJ cord-353298-vr5hnzp8 8 17 phenotype phenotype NN cord-353298-vr5hnzp8 8 18 and and CC cord-353298-vr5hnzp8 8 19 mitotic mitotic JJ cord-353298-vr5hnzp8 8 20 potential potential NN cord-353298-vr5hnzp8 8 21 of of IN cord-353298-vr5hnzp8 8 22 individual individual JJ cord-353298-vr5hnzp8 8 23 glial glial JJ cord-353298-vr5hnzp8 8 24 cells cell NNS cord-353298-vr5hnzp8 8 25 . . . cord-353298-vr5hnzp8 9 1 We -PRON- PRP cord-353298-vr5hnzp8 9 2 identified identify VBD cord-353298-vr5hnzp8 9 3 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 9 4 with with IN cord-353298-vr5hnzp8 9 5 an an DT cord-353298-vr5hnzp8 9 6 antibody antibody NN cord-353298-vr5hnzp8 9 7 to to IN cord-353298-vr5hnzp8 9 8 galactocerebroside galactocerebroside NN cord-353298-vr5hnzp8 9 9 , , , cord-353298-vr5hnzp8 9 10 astrocytes astrocyte NNS cord-353298-vr5hnzp8 9 11 with with IN cord-353298-vr5hnzp8 9 12 an an DT cord-353298-vr5hnzp8 9 13 antibody antibody NN cord-353298-vr5hnzp8 9 14 to to TO cord-353298-vr5hnzp8 9 15 glial glial JJ cord-353298-vr5hnzp8 9 16 fibrillary fibrillary JJ cord-353298-vr5hnzp8 9 17 acidic acidic JJ cord-353298-vr5hnzp8 9 18 protein protein NN cord-353298-vr5hnzp8 9 19 , , , cord-353298-vr5hnzp8 9 20 and and CC cord-353298-vr5hnzp8 9 21 oligodendrocyte oligodendrocyte JJ cord-353298-vr5hnzp8 9 22 - - HYPH cord-353298-vr5hnzp8 9 23 type type NN cord-353298-vr5hnzp8 9 24 2 2 CD cord-353298-vr5hnzp8 9 25 astrocyte astrocyte NN cord-353298-vr5hnzp8 9 26 ( ( -LRB- cord-353298-vr5hnzp8 9 27 O-2A O-2A NNP cord-353298-vr5hnzp8 9 28 ) ) -RRB- cord-353298-vr5hnzp8 9 29 progenitor progenitor NN cord-353298-vr5hnzp8 9 30 cells cell NNS cord-353298-vr5hnzp8 9 31 with with IN cord-353298-vr5hnzp8 9 32 the the DT cord-353298-vr5hnzp8 9 33 O4 O4 NNP cord-353298-vr5hnzp8 9 34 antibody antibody NN cord-353298-vr5hnzp8 9 35 . . . cord-353298-vr5hnzp8 10 1 Cultures culture NNS cord-353298-vr5hnzp8 10 2 from from IN cord-353298-vr5hnzp8 10 3 demyelinated demyelinated JJ cord-353298-vr5hnzp8 10 4 tissue tissue NN cord-353298-vr5hnzp8 10 5 differed differ VBD cord-353298-vr5hnzp8 10 6 in in IN cord-353298-vr5hnzp8 10 7 several several JJ cord-353298-vr5hnzp8 10 8 ways way NNS cord-353298-vr5hnzp8 10 9 from from IN cord-353298-vr5hnzp8 10 10 those those DT cord-353298-vr5hnzp8 10 11 of of IN cord-353298-vr5hnzp8 10 12 age age NN cord-353298-vr5hnzp8 10 13 - - HYPH cord-353298-vr5hnzp8 10 14 matched match VBN cord-353298-vr5hnzp8 10 15 controls control NNS cord-353298-vr5hnzp8 10 16 : : : cord-353298-vr5hnzp8 11 1 first first RB cord-353298-vr5hnzp8 11 2 , , , cord-353298-vr5hnzp8 11 3 the the DT cord-353298-vr5hnzp8 11 4 total total JJ cord-353298-vr5hnzp8 11 5 number number NN cord-353298-vr5hnzp8 11 6 of of IN cord-353298-vr5hnzp8 11 7 O-2A O-2A NNP cord-353298-vr5hnzp8 11 8 lineage lineage NN cord-353298-vr5hnzp8 11 9 cells cell NNS cord-353298-vr5hnzp8 11 10 was be VBD cord-353298-vr5hnzp8 11 11 strikingly strikingly RB cord-353298-vr5hnzp8 11 12 increased increase VBN cord-353298-vr5hnzp8 11 13 ; ; : cord-353298-vr5hnzp8 11 14 second second RB cord-353298-vr5hnzp8 11 15 , , , cord-353298-vr5hnzp8 11 16 the the DT cord-353298-vr5hnzp8 11 17 O-2A O-2A NNP cord-353298-vr5hnzp8 11 18 population population NN cord-353298-vr5hnzp8 11 19 consisted consist VBD cord-353298-vr5hnzp8 11 20 of of IN cord-353298-vr5hnzp8 11 21 a a DT cord-353298-vr5hnzp8 11 22 higher high JJR cord-353298-vr5hnzp8 11 23 proportion proportion NN cord-353298-vr5hnzp8 11 24 of of IN cord-353298-vr5hnzp8 11 25 O4-positive O4-positive NNS cord-353298-vr5hnzp8 11 26 astrocytes astrocyte NNS cord-353298-vr5hnzp8 11 27 and and CC cord-353298-vr5hnzp8 11 28 cells cell NNS cord-353298-vr5hnzp8 11 29 of of IN cord-353298-vr5hnzp8 11 30 mixed mixed JJ cord-353298-vr5hnzp8 11 31 oligodendrocyte oligodendrocyte NNP cord-353298-vr5hnzp8 11 32 - - HYPH cord-353298-vr5hnzp8 11 33 astrocyte astrocyte JJ cord-353298-vr5hnzp8 11 34 phenotype phenotype NN cord-353298-vr5hnzp8 11 35 ; ; : cord-353298-vr5hnzp8 11 36 and and CC cord-353298-vr5hnzp8 11 37 third third RB cord-353298-vr5hnzp8 11 38 , , , cord-353298-vr5hnzp8 11 39 all all PDT cord-353298-vr5hnzp8 11 40 the the DT cord-353298-vr5hnzp8 11 41 cell cell NN cord-353298-vr5hnzp8 11 42 types type NNS cord-353298-vr5hnzp8 11 43 within within IN cord-353298-vr5hnzp8 11 44 the the DT cord-353298-vr5hnzp8 11 45 O-2A O-2A NNP cord-353298-vr5hnzp8 11 46 lineage lineage NN cord-353298-vr5hnzp8 11 47 showed show VBD cord-353298-vr5hnzp8 11 48 enhanced enhanced JJ cord-353298-vr5hnzp8 11 49 proliferation proliferation NN cord-353298-vr5hnzp8 11 50 . . . cord-353298-vr5hnzp8 12 1 This this DT cord-353298-vr5hnzp8 12 2 proliferation proliferation NN cord-353298-vr5hnzp8 12 3 was be VBD cord-353298-vr5hnzp8 12 4 not not RB cord-353298-vr5hnzp8 12 5 further further RB cord-353298-vr5hnzp8 12 6 enhanced enhance VBN cord-353298-vr5hnzp8 12 7 by by IN cord-353298-vr5hnzp8 12 8 adding add VBG cord-353298-vr5hnzp8 12 9 PDGF PDGF NNP cord-353298-vr5hnzp8 12 10 , , , cord-353298-vr5hnzp8 12 11 basic basic JJ cord-353298-vr5hnzp8 12 12 fibroblast fibroblast NN cord-353298-vr5hnzp8 12 13 growth growth NN cord-353298-vr5hnzp8 12 14 factor factor NN cord-353298-vr5hnzp8 12 15 ( ( -LRB- cord-353298-vr5hnzp8 12 16 bFGF bFGF NNP cord-353298-vr5hnzp8 12 17 ) ) -RRB- cord-353298-vr5hnzp8 12 18 , , , cord-353298-vr5hnzp8 12 19 or or CC cord-353298-vr5hnzp8 12 20 insulin insulin NN cord-353298-vr5hnzp8 12 21 - - HYPH cord-353298-vr5hnzp8 12 22 like like JJ cord-353298-vr5hnzp8 12 23 growth growth NN cord-353298-vr5hnzp8 12 24 factor factor NN cord-353298-vr5hnzp8 13 1 I -PRON- PRP cord-353298-vr5hnzp8 13 2 ( ( -LRB- cord-353298-vr5hnzp8 13 3 IGF IGF NNP cord-353298-vr5hnzp8 13 4 - - HYPH cord-353298-vr5hnzp8 13 5 I I NNP cord-353298-vr5hnzp8 13 6 ) ) -RRB- cord-353298-vr5hnzp8 13 7 to to IN cord-353298-vr5hnzp8 13 8 the the DT cord-353298-vr5hnzp8 13 9 defined define VBN cord-353298-vr5hnzp8 13 10 medium medium NN cord-353298-vr5hnzp8 13 11 . . . cord-353298-vr5hnzp8 14 1 However however RB cord-353298-vr5hnzp8 14 2 , , , cord-353298-vr5hnzp8 14 3 bFGF bfgf NN cord-353298-vr5hnzp8 14 4 and and CC cord-353298-vr5hnzp8 14 5 IGF IGF NNP cord-353298-vr5hnzp8 14 6 - - : cord-353298-vr5hnzp8 14 7 I -PRON- PRP cord-353298-vr5hnzp8 14 8 seemed seem VBD cord-353298-vr5hnzp8 14 9 to to TO cord-353298-vr5hnzp8 14 10 influence influence VB cord-353298-vr5hnzp8 14 11 the the DT cord-353298-vr5hnzp8 14 12 fate fate NN cord-353298-vr5hnzp8 14 13 of of IN cord-353298-vr5hnzp8 14 14 O-2A O-2A NNP cord-353298-vr5hnzp8 14 15 lineage lineage NN cord-353298-vr5hnzp8 14 16 cells cell NNS cord-353298-vr5hnzp8 14 17 in in IN cord-353298-vr5hnzp8 14 18 cultures culture NNS cord-353298-vr5hnzp8 14 19 of of IN cord-353298-vr5hnzp8 14 20 demyelinated demyelinated JJ cord-353298-vr5hnzp8 14 21 tissue tissue NN cord-353298-vr5hnzp8 14 22 . . . cord-353298-vr5hnzp8 15 1 Basic basic JJ cord-353298-vr5hnzp8 15 2 FGF FGF NNP cord-353298-vr5hnzp8 15 3 decreased decrease VBD cord-353298-vr5hnzp8 15 4 the the DT cord-353298-vr5hnzp8 15 5 percentage percentage NN cord-353298-vr5hnzp8 15 6 of of IN cord-353298-vr5hnzp8 15 7 cells cell NNS cord-353298-vr5hnzp8 15 8 expressing express VBG cord-353298-vr5hnzp8 15 9 galactocerebroside galactocerebroside NN cord-353298-vr5hnzp8 15 10 . . . cord-353298-vr5hnzp8 16 1 In in IN cord-353298-vr5hnzp8 16 2 contrast contrast NN cord-353298-vr5hnzp8 16 3 , , , cord-353298-vr5hnzp8 16 4 IGF IGF NNP cord-353298-vr5hnzp8 16 5 - - HYPH cord-353298-vr5hnzp8 16 6 I -PRON- PRP cord-353298-vr5hnzp8 16 7 increased increase VBD cord-353298-vr5hnzp8 16 8 the the DT cord-353298-vr5hnzp8 16 9 relative relative JJ cord-353298-vr5hnzp8 16 10 proportion proportion NN cord-353298-vr5hnzp8 16 11 of of IN cord-353298-vr5hnzp8 16 12 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 16 13 . . . cord-353298-vr5hnzp8 17 1 Thus thus RB cord-353298-vr5hnzp8 17 2 , , , cord-353298-vr5hnzp8 17 3 O-2A O-2A NNP cord-353298-vr5hnzp8 17 4 lineage lineage NN cord-353298-vr5hnzp8 17 5 cells cell NNS cord-353298-vr5hnzp8 17 6 from from IN cord-353298-vr5hnzp8 17 7 adult adult NN cord-353298-vr5hnzp8 17 8 mice mouse NNS cord-353298-vr5hnzp8 17 9 display display VBP cord-353298-vr5hnzp8 17 10 greater great JJR cord-353298-vr5hnzp8 17 11 phenotypic phenotypic JJ cord-353298-vr5hnzp8 17 12 plasticity plasticity NN cord-353298-vr5hnzp8 17 13 and and CC cord-353298-vr5hnzp8 17 14 enhanced enhance VBN cord-353298-vr5hnzp8 17 15 mitotic mitotic JJ cord-353298-vr5hnzp8 17 16 potential potential NN cord-353298-vr5hnzp8 17 17 in in IN cord-353298-vr5hnzp8 17 18 response response NN cord-353298-vr5hnzp8 17 19 to to IN cord-353298-vr5hnzp8 17 20 an an DT cord-353298-vr5hnzp8 17 21 episode episode NN cord-353298-vr5hnzp8 17 22 of of IN cord-353298-vr5hnzp8 17 23 demyelination demyelination NN cord-353298-vr5hnzp8 17 24 . . . cord-353298-vr5hnzp8 18 1 These these DT cord-353298-vr5hnzp8 18 2 properties property NNS cord-353298-vr5hnzp8 18 3 may may MD cord-353298-vr5hnzp8 18 4 be be VB cord-353298-vr5hnzp8 18 5 linked link VBN cord-353298-vr5hnzp8 18 6 to to IN cord-353298-vr5hnzp8 18 7 the the DT cord-353298-vr5hnzp8 18 8 efficient efficient JJ cord-353298-vr5hnzp8 18 9 remyelination remyelination NN cord-353298-vr5hnzp8 18 10 achieved achieve VBN cord-353298-vr5hnzp8 18 11 in in IN cord-353298-vr5hnzp8 18 12 this this DT cord-353298-vr5hnzp8 18 13 demyelinating demyelinating JJ cord-353298-vr5hnzp8 18 14 disease disease NN cord-353298-vr5hnzp8 18 15 . . . cord-353298-vr5hnzp8 19 1 C57B1/6N C57B1/6N NNP cord-353298-vr5hnzp8 19 2 mice mouse NNS cord-353298-vr5hnzp8 19 3 by by IN cord-353298-vr5hnzp8 19 4 intracranial intracranial JJ cord-353298-vr5hnzp8 19 5 injection injection NN cord-353298-vr5hnzp8 19 6 of of IN cord-353298-vr5hnzp8 19 7 a a DT cord-353298-vr5hnzp8 19 8 coronavirus coronavirus NN cord-353298-vr5hnzp8 20 1 ( ( -LRB- cord-353298-vr5hnzp8 20 2 murine murine JJ cord-353298-vr5hnzp8 20 3 hepatitis hepatitis NN cord-353298-vr5hnzp8 20 4 virus virus NN cord-353298-vr5hnzp8 20 5 strain strain NN cord-353298-vr5hnzp8 20 6 A59 A59 NNP cord-353298-vr5hnzp8 20 7 ) ) -RRB- cord-353298-vr5hnzp8 20 8 is be VBZ cord-353298-vr5hnzp8 20 9 followed follow VBN cord-353298-vr5hnzp8 20 10 by by IN cord-353298-vr5hnzp8 20 11 functional functional JJ cord-353298-vr5hnzp8 20 12 recovery recovery NN cord-353298-vr5hnzp8 20 13 and and CC cord-353298-vr5hnzp8 20 14 efficient efficient JJ cord-353298-vr5hnzp8 20 15 CNS CNS NNP cord-353298-vr5hnzp8 20 16 myelin myelin NN cord-353298-vr5hnzp8 20 17 repair repair NN cord-353298-vr5hnzp8 20 18 . . . cord-353298-vr5hnzp8 21 1 To to TO cord-353298-vr5hnzp8 21 2 study study VB cord-353298-vr5hnzp8 21 3 the the DT cord-353298-vr5hnzp8 21 4 biological biological JJ cord-353298-vr5hnzp8 21 5 properties property NNS cord-353298-vr5hnzp8 21 6 of of IN cord-353298-vr5hnzp8 21 7 the the DT cord-353298-vr5hnzp8 21 8 cells cell NNS cord-353298-vr5hnzp8 21 9 involved involve VBN cord-353298-vr5hnzp8 21 10 in in IN cord-353298-vr5hnzp8 21 11 this this DT cord-353298-vr5hnzp8 21 12 repair repair NN cord-353298-vr5hnzp8 21 13 process process NN cord-353298-vr5hnzp8 21 14 , , , cord-353298-vr5hnzp8 21 15 glial glial JJ cord-353298-vr5hnzp8 21 16 ceils ceil NNS cord-353298-vr5hnzp8 21 17 were be VBD cord-353298-vr5hnzp8 21 18 isolated isolate VBN cord-353298-vr5hnzp8 21 19 and and CC cord-353298-vr5hnzp8 21 20 cultured culture VBN cord-353298-vr5hnzp8 21 21 from from IN cord-353298-vr5hnzp8 21 22 spinal spinal JJ cord-353298-vr5hnzp8 21 23 cords cord NNS cord-353298-vr5hnzp8 21 24 of of IN cord-353298-vr5hnzp8 21 25 these these DT cord-353298-vr5hnzp8 21 26 young young JJ cord-353298-vr5hnzp8 21 27 adult adult NN cord-353298-vr5hnzp8 21 28 mice mouse NNS cord-353298-vr5hnzp8 21 29 during during IN cord-353298-vr5hnzp8 21 30 demyelination demyelination NN cord-353298-vr5hnzp8 21 31 and and CC cord-353298-vr5hnzp8 21 32 remyelination remyelination NN cord-353298-vr5hnzp8 21 33 . . . cord-353298-vr5hnzp8 22 1 Using use VBG cord-353298-vr5hnzp8 22 2 three three CD cord-353298-vr5hnzp8 22 3 - - HYPH cord-353298-vr5hnzp8 22 4 color color NN cord-353298-vr5hnzp8 22 5 immunofluorescence immunofluorescence NN cord-353298-vr5hnzp8 22 6 combined combine VBN cord-353298-vr5hnzp8 22 7 with with IN cord-353298-vr5hnzp8 22 8 [ [ -LRB- cord-353298-vr5hnzp8 22 9 3H]thymidine 3h]thymidine CD cord-353298-vr5hnzp8 22 10 autoradiography autoradiography NNP cord-353298-vr5hnzp8 22 11 , , , cord-353298-vr5hnzp8 22 12 we -PRON- PRP cord-353298-vr5hnzp8 22 13 have have VBP cord-353298-vr5hnzp8 22 14 analyzed analyze VBN cord-353298-vr5hnzp8 22 15 the the DT cord-353298-vr5hnzp8 22 16 antigenic antigenic JJ cord-353298-vr5hnzp8 22 17 phenotype phenotype NN cord-353298-vr5hnzp8 22 18 and and CC cord-353298-vr5hnzp8 22 19 mitotic mitotic JJ cord-353298-vr5hnzp8 22 20 potential potential NN cord-353298-vr5hnzp8 22 21 of of IN cord-353298-vr5hnzp8 22 22 individual individual JJ cord-353298-vr5hnzp8 22 23 glial glial JJ cord-353298-vr5hnzp8 22 24 cells cell NNS cord-353298-vr5hnzp8 22 25 . . . cord-353298-vr5hnzp8 23 1 We -PRON- PRP cord-353298-vr5hnzp8 23 2 identified identify VBD cord-353298-vr5hnzp8 23 3 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 23 4 with with IN cord-353298-vr5hnzp8 23 5 an an DT cord-353298-vr5hnzp8 23 6 antibody antibody NN cord-353298-vr5hnzp8 23 7 to to IN cord-353298-vr5hnzp8 23 8 galactocerebroside galactocerebroside NN cord-353298-vr5hnzp8 23 9 , , , cord-353298-vr5hnzp8 23 10 astrocytes astrocyte NNS cord-353298-vr5hnzp8 23 11 with with IN cord-353298-vr5hnzp8 23 12 an an DT cord-353298-vr5hnzp8 23 13 antibody antibody NN cord-353298-vr5hnzp8 23 14 to to TO cord-353298-vr5hnzp8 23 15 glial glial JJ cord-353298-vr5hnzp8 23 16 fibrillary fibrillary JJ cord-353298-vr5hnzp8 23 17 acidic acidic JJ cord-353298-vr5hnzp8 23 18 protein protein NN cord-353298-vr5hnzp8 23 19 , , , cord-353298-vr5hnzp8 23 20 and and CC cord-353298-vr5hnzp8 23 21 oligodendrocyte oligodendrocyte JJ cord-353298-vr5hnzp8 23 22 - - HYPH cord-353298-vr5hnzp8 23 23 type type NN cord-353298-vr5hnzp8 23 24 2 2 CD cord-353298-vr5hnzp8 23 25 astrocyte astrocyte NN cord-353298-vr5hnzp8 23 26 ( ( -LRB- cord-353298-vr5hnzp8 23 27 O-2A O-2A NNP cord-353298-vr5hnzp8 23 28 ) ) -RRB- cord-353298-vr5hnzp8 23 29 progenitor progenitor NN cord-353298-vr5hnzp8 23 30 cells cell NNS cord-353298-vr5hnzp8 23 31 with with IN cord-353298-vr5hnzp8 23 32 the the DT cord-353298-vr5hnzp8 23 33 04 04 CD cord-353298-vr5hnzp8 23 34 antibody antibody NN cord-353298-vr5hnzp8 23 35 . . . cord-353298-vr5hnzp8 24 1 Cultures culture NNS cord-353298-vr5hnzp8 24 2 from from IN cord-353298-vr5hnzp8 24 3 demyelinated demyelinated JJ cord-353298-vr5hnzp8 24 4 tissue tissue NN cord-353298-vr5hnzp8 24 5 differed differ VBD cord-353298-vr5hnzp8 24 6 in in IN cord-353298-vr5hnzp8 24 7 several several JJ cord-353298-vr5hnzp8 24 8 ways way NNS cord-353298-vr5hnzp8 24 9 from from IN cord-353298-vr5hnzp8 24 10 those those DT cord-353298-vr5hnzp8 24 11 of of IN cord-353298-vr5hnzp8 24 12 agematched agematched JJ cord-353298-vr5hnzp8 24 13 controls control NNS cord-353298-vr5hnzp8 24 14 : : : cord-353298-vr5hnzp8 25 1 first first RB cord-353298-vr5hnzp8 25 2 , , , cord-353298-vr5hnzp8 25 3 the the DT cord-353298-vr5hnzp8 25 4 total total JJ cord-353298-vr5hnzp8 25 5 number number NN cord-353298-vr5hnzp8 25 6 of of IN cord-353298-vr5hnzp8 25 7 O-2A O-2A NNP cord-353298-vr5hnzp8 25 8 lin lin NNP cord-353298-vr5hnzp8 25 9 - - HYPH cord-353298-vr5hnzp8 25 10 cage cage NN cord-353298-vr5hnzp8 25 11 cells cell NNS cord-353298-vr5hnzp8 25 12 was be VBD cord-353298-vr5hnzp8 25 13 strikingly strikingly RB cord-353298-vr5hnzp8 25 14 increased increase VBN cord-353298-vr5hnzp8 25 15 ; ; : cord-353298-vr5hnzp8 25 16 second second RB cord-353298-vr5hnzp8 25 17 , , , cord-353298-vr5hnzp8 25 18 the the DT cord-353298-vr5hnzp8 25 19 O-2A O-2A NNP cord-353298-vr5hnzp8 25 20 population population NN cord-353298-vr5hnzp8 25 21 consisted consist VBD cord-353298-vr5hnzp8 25 22 of of IN cord-353298-vr5hnzp8 25 23 a a DT cord-353298-vr5hnzp8 25 24 higher high JJR cord-353298-vr5hnzp8 25 25 proportion proportion NN cord-353298-vr5hnzp8 25 26 of of IN cord-353298-vr5hnzp8 25 27 04positive 04positive CD cord-353298-vr5hnzp8 25 28 astrocytes astrocyte NNS cord-353298-vr5hnzp8 25 29 and and CC cord-353298-vr5hnzp8 25 30 cells cell NNS cord-353298-vr5hnzp8 25 31 of of IN cord-353298-vr5hnzp8 25 32 mixed mixed JJ cord-353298-vr5hnzp8 25 33 oligodendrocyteastrocyte oligodendrocyteastrocyte NN cord-353298-vr5hnzp8 25 34 phenotype phenotype NN cord-353298-vr5hnzp8 25 35 ; ; : cord-353298-vr5hnzp8 25 36 and and CC cord-353298-vr5hnzp8 25 37 third third RB cord-353298-vr5hnzp8 25 38 , , , cord-353298-vr5hnzp8 25 39 all all PDT cord-353298-vr5hnzp8 25 40 the the DT cord-353298-vr5hnzp8 25 41 cell cell NN cord-353298-vr5hnzp8 25 42 types type NNS cord-353298-vr5hnzp8 25 43 within within IN cord-353298-vr5hnzp8 25 44 the the DT cord-353298-vr5hnzp8 25 45 O-2A O-2A NNP cord-353298-vr5hnzp8 25 46 lineage lineage NN cord-353298-vr5hnzp8 25 47 showed show VBD cord-353298-vr5hnzp8 25 48 enhanced enhanced JJ cord-353298-vr5hnzp8 25 49 proliferation proliferation NN cord-353298-vr5hnzp8 25 50 . . . cord-353298-vr5hnzp8 26 1 This this DT cord-353298-vr5hnzp8 26 2 proliferation proliferation NN cord-353298-vr5hnzp8 26 3 was be VBD cord-353298-vr5hnzp8 26 4 not not RB cord-353298-vr5hnzp8 26 5 further further RB cord-353298-vr5hnzp8 26 6 enhanced enhance VBN cord-353298-vr5hnzp8 26 7 by by IN cord-353298-vr5hnzp8 26 8 adding add VBG cord-353298-vr5hnzp8 26 9 PDGF PDGF NNP cord-353298-vr5hnzp8 26 10 , , , cord-353298-vr5hnzp8 26 11 basic basic JJ cord-353298-vr5hnzp8 26 12 fibroblast fibroblast NN cord-353298-vr5hnzp8 26 13 growth growth NN cord-353298-vr5hnzp8 26 14 factor factor NN cord-353298-vr5hnzp8 26 15 ( ( -LRB- cord-353298-vr5hnzp8 26 16 bFGF bFGF NNP cord-353298-vr5hnzp8 26 17 ) ) -RRB- cord-353298-vr5hnzp8 26 18 , , , cord-353298-vr5hnzp8 26 19 or or CC cord-353298-vr5hnzp8 26 20 insulin insulin NN cord-353298-vr5hnzp8 26 21 - - HYPH cord-353298-vr5hnzp8 26 22 like like JJ cord-353298-vr5hnzp8 26 23 growth growth NN cord-353298-vr5hnzp8 26 24 factor factor NN cord-353298-vr5hnzp8 27 1 I -PRON- PRP cord-353298-vr5hnzp8 27 2 ( ( -LRB- cord-353298-vr5hnzp8 27 3 IGF IGF NNP cord-353298-vr5hnzp8 27 4 - - HYPH cord-353298-vr5hnzp8 27 5 I I NNP cord-353298-vr5hnzp8 27 6 ) ) -RRB- cord-353298-vr5hnzp8 27 7 to to IN cord-353298-vr5hnzp8 27 8 the the DT cord-353298-vr5hnzp8 27 9 defined define VBN cord-353298-vr5hnzp8 27 10 medium medium NN cord-353298-vr5hnzp8 27 11 . . . cord-353298-vr5hnzp8 28 1 However however RB cord-353298-vr5hnzp8 28 2 , , , cord-353298-vr5hnzp8 28 3 bFGF bfgf NN cord-353298-vr5hnzp8 28 4 and and CC cord-353298-vr5hnzp8 28 5 IGF IGF NNP cord-353298-vr5hnzp8 28 6 - - : cord-353298-vr5hnzp8 28 7 I -PRON- PRP cord-353298-vr5hnzp8 28 8 seemed seem VBD cord-353298-vr5hnzp8 28 9 to to TO cord-353298-vr5hnzp8 28 10 influence influence VB cord-353298-vr5hnzp8 28 11 the the DT cord-353298-vr5hnzp8 28 12 fate fate NN cord-353298-vr5hnzp8 28 13 of of IN cord-353298-vr5hnzp8 28 14 O-2A O-2A NNP cord-353298-vr5hnzp8 28 15 lineage lineage NN cord-353298-vr5hnzp8 28 16 cells cell NNS cord-353298-vr5hnzp8 28 17 in in IN cord-353298-vr5hnzp8 28 18 cultures culture NNS cord-353298-vr5hnzp8 28 19 of of IN cord-353298-vr5hnzp8 28 20 demyelinated demyelinated JJ cord-353298-vr5hnzp8 28 21 tissue tissue NN cord-353298-vr5hnzp8 28 22 . . . cord-353298-vr5hnzp8 29 1 Basic basic JJ cord-353298-vr5hnzp8 29 2 FGF FGF NNP cord-353298-vr5hnzp8 29 3 decreased decrease VBD cord-353298-vr5hnzp8 29 4 the the DT cord-353298-vr5hnzp8 29 5 percentage percentage NN cord-353298-vr5hnzp8 29 6 of of IN cord-353298-vr5hnzp8 29 7 cells cell NNS cord-353298-vr5hnzp8 29 8 expressing express VBG cord-353298-vr5hnzp8 29 9 galactocerebroside galactocerebroside NN cord-353298-vr5hnzp8 29 10 . . . cord-353298-vr5hnzp8 30 1 In in IN cord-353298-vr5hnzp8 30 2 contrast contrast NN cord-353298-vr5hnzp8 30 3 , , , cord-353298-vr5hnzp8 30 4 IGF IGF NNP cord-353298-vr5hnzp8 30 5 - - HYPH cord-353298-vr5hnzp8 30 6 I -PRON- PRP cord-353298-vr5hnzp8 30 7 increased increase VBD cord-353298-vr5hnzp8 30 8 the the DT cord-353298-vr5hnzp8 30 9 relative relative JJ cord-353298-vr5hnzp8 30 10 proportion proportion NN cord-353298-vr5hnzp8 30 11 of of IN cord-353298-vr5hnzp8 30 12 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 30 13 . . . cord-353298-vr5hnzp8 31 1 Thus thus RB cord-353298-vr5hnzp8 31 2 , , , cord-353298-vr5hnzp8 31 3 O-2A O-2A NNP cord-353298-vr5hnzp8 31 4 lineage lineage NN cord-353298-vr5hnzp8 31 5 cells cell NNS cord-353298-vr5hnzp8 31 6 from from IN cord-353298-vr5hnzp8 31 7 adult adult NN cord-353298-vr5hnzp8 31 8 mice mouse NNS cord-353298-vr5hnzp8 31 9 display display VBP cord-353298-vr5hnzp8 31 10 greater great JJR cord-353298-vr5hnzp8 31 11 phenotypic phenotypic JJ cord-353298-vr5hnzp8 31 12 plasticity plasticity NN cord-353298-vr5hnzp8 31 13 and and CC cord-353298-vr5hnzp8 31 14 enhanced enhance VBN cord-353298-vr5hnzp8 31 15 mitotic mitotic JJ cord-353298-vr5hnzp8 31 16 potential potential NN cord-353298-vr5hnzp8 31 17 in in IN cord-353298-vr5hnzp8 31 18 response response NN cord-353298-vr5hnzp8 31 19 to to IN cord-353298-vr5hnzp8 31 20 an an DT cord-353298-vr5hnzp8 31 21 episode episode NN cord-353298-vr5hnzp8 31 22 of of IN cord-353298-vr5hnzp8 31 23 demyelination demyelination NN cord-353298-vr5hnzp8 31 24 . . . cord-353298-vr5hnzp8 32 1 These these DT cord-353298-vr5hnzp8 32 2 properties property NNS cord-353298-vr5hnzp8 32 3 may may MD cord-353298-vr5hnzp8 32 4 be be VB cord-353298-vr5hnzp8 32 5 linked link VBN cord-353298-vr5hnzp8 32 6 to to IN cord-353298-vr5hnzp8 32 7 the the DT cord-353298-vr5hnzp8 32 8 efficient efficient JJ cord-353298-vr5hnzp8 32 9 remyelination remyelination NN cord-353298-vr5hnzp8 32 10 achieved achieve VBN cord-353298-vr5hnzp8 32 11 in in IN cord-353298-vr5hnzp8 32 12 this this DT cord-353298-vr5hnzp8 32 13 demyelinating demyelinating JJ cord-353298-vr5hnzp8 32 14 disease disease NN cord-353298-vr5hnzp8 32 15 . . . cord-353298-vr5hnzp8 33 1 I -PRON- PRP cord-353298-vr5hnzp8 33 2 ~ ~ NFP cord-353298-vr5hnzp8 33 3 demyelinating demyelinate VBG cord-353298-vr5hnzp8 33 4 diseases disease NNS cord-353298-vr5hnzp8 33 5 , , , cord-353298-vr5hnzp8 33 6 damage damage NN cord-353298-vr5hnzp8 33 7 to to IN cord-353298-vr5hnzp8 33 8 myelin myelin JJ cord-353298-vr5hnzp8 33 9 sheaths sheath NNS cord-353298-vr5hnzp8 33 10 disrupts disrupt VBZ cord-353298-vr5hnzp8 33 11 conduction conduction NN cord-353298-vr5hnzp8 33 12 of of IN cord-353298-vr5hnzp8 33 13 electrical electrical JJ cord-353298-vr5hnzp8 33 14 impulses impulse NNS cord-353298-vr5hnzp8 33 15 along along IN cord-353298-vr5hnzp8 33 16 axonal axonal JJ cord-353298-vr5hnzp8 33 17 processes process NNS cord-353298-vr5hnzp8 33 18 of of IN cord-353298-vr5hnzp8 33 19 neurons neuron NNS cord-353298-vr5hnzp8 33 20 . . . cord-353298-vr5hnzp8 34 1 Typically typically RB cord-353298-vr5hnzp8 34 2 , , , cord-353298-vr5hnzp8 34 3 damaged damaged JJ cord-353298-vr5hnzp8 34 4 myelin myelin NN cord-353298-vr5hnzp8 34 5 is be VBZ cord-353298-vr5hnzp8 34 6 not not RB cord-353298-vr5hnzp8 34 7 efficiently efficiently RB cord-353298-vr5hnzp8 34 8 repaired repair VBN cord-353298-vr5hnzp8 34 9 in in IN cord-353298-vr5hnzp8 34 10 the the DT cord-353298-vr5hnzp8 34 11 human human JJ cord-353298-vr5hnzp8 34 12 CNS CNS NNP cord-353298-vr5hnzp8 34 13 ( ( -LRB- cord-353298-vr5hnzp8 34 14 Perier Perier NNP cord-353298-vr5hnzp8 34 15 and and CC cord-353298-vr5hnzp8 34 16 Gregoire Gregoire NNP cord-353298-vr5hnzp8 34 17 , , , cord-353298-vr5hnzp8 34 18 1965 1965 CD cord-353298-vr5hnzp8 34 19 ; ; : cord-353298-vr5hnzp8 35 1 Prineas Prineas NNP cord-353298-vr5hnzp8 35 2 et et NNP cord-353298-vr5hnzp8 35 3 al al NNP cord-353298-vr5hnzp8 35 4 . . NNP cord-353298-vr5hnzp8 35 5 , , , cord-353298-vr5hnzp8 35 6 1984 1984 CD cord-353298-vr5hnzp8 35 7 ) ) -RRB- cord-353298-vr5hnzp8 35 8 . . . cord-353298-vr5hnzp8 36 1 Thus thus RB cord-353298-vr5hnzp8 36 2 patients patient NNS cord-353298-vr5hnzp8 36 3 with with IN cord-353298-vr5hnzp8 36 4 CNS CNS NNP cord-353298-vr5hnzp8 36 5 demyelinating demyelinate VBG cord-353298-vr5hnzp8 36 6 diseases disease NNS cord-353298-vr5hnzp8 36 7 , , , cord-353298-vr5hnzp8 36 8 such such JJ cord-353298-vr5hnzp8 36 9 as as IN cord-353298-vr5hnzp8 36 10 multiple multiple JJ cord-353298-vr5hnzp8 36 11 sclerosis sclerosis NN cord-353298-vr5hnzp8 36 12 , , , cord-353298-vr5hnzp8 36 13 frequently frequently RB cord-353298-vr5hnzp8 36 14 experience experience VBP cord-353298-vr5hnzp8 36 15 prolonged prolong VBN cord-353298-vr5hnzp8 36 16 neurological neurological JJ cord-353298-vr5hnzp8 36 17 dysfunction dysfunction NN cord-353298-vr5hnzp8 36 18 . . . cord-353298-vr5hnzp8 37 1 In in IN cord-353298-vr5hnzp8 37 2 contrast contrast NN cord-353298-vr5hnzp8 37 3 , , , cord-353298-vr5hnzp8 37 4 efficient efficient JJ cord-353298-vr5hnzp8 37 5 remyelination remyelination NN cord-353298-vr5hnzp8 37 6 and and CC cord-353298-vr5hnzp8 37 7 functional functional JJ cord-353298-vr5hnzp8 37 8 recovery recovery NN cord-353298-vr5hnzp8 37 9 is be VBZ cord-353298-vr5hnzp8 37 10 achieved achieve VBN cord-353298-vr5hnzp8 37 11 in in IN cord-353298-vr5hnzp8 37 12 rodents rodent NNS cord-353298-vr5hnzp8 37 13 in in IN cord-353298-vr5hnzp8 37 14 certain certain JJ cord-353298-vr5hnzp8 37 15 experimental experimental JJ cord-353298-vr5hnzp8 37 16 models model NNS cord-353298-vr5hnzp8 37 17 of of IN cord-353298-vr5hnzp8 37 18 CNS CNS NNP cord-353298-vr5hnzp8 37 19 demyelination demyelination NN cord-353298-vr5hnzp8 37 20 ( ( -LRB- cord-353298-vr5hnzp8 37 21 reviewed review VBN cord-353298-vr5hnzp8 37 22 in in IN cord-353298-vr5hnzp8 37 23 Ludwin Ludwin NNP cord-353298-vr5hnzp8 37 24 , , , cord-353298-vr5hnzp8 37 25 1981 1981 CD cord-353298-vr5hnzp8 37 26 ) ) -RRB- cord-353298-vr5hnzp8 37 27 . . . cord-353298-vr5hnzp8 38 1 One one CD cord-353298-vr5hnzp8 38 2 such such JJ cord-353298-vr5hnzp8 38 3 model model NN cord-353298-vr5hnzp8 38 4 is be VBZ cord-353298-vr5hnzp8 38 5 produced produce VBN cord-353298-vr5hnzp8 38 6 by by IN cord-353298-vr5hnzp8 38 7 infecting infect VBG cord-353298-vr5hnzp8 38 8 C57B1/6N C57B1/6N NNP cord-353298-vr5hnzp8 38 9 mice mouse NNS cord-353298-vr5hnzp8 38 10 with with IN cord-353298-vr5hnzp8 38 11 a a DT cord-353298-vr5hnzp8 38 12 coronavirus coronavirus NN cord-353298-vr5hnzp8 38 13 ( ( -LRB- cord-353298-vr5hnzp8 38 14 murine murine JJ cord-353298-vr5hnzp8 38 15 hepatitis hepatitis NN cord-353298-vr5hnzp8 38 16 virus virus NN cord-353298-vr5hnzp8 38 17 strain strain VBP cord-353298-vr5hnzp8 38 18 A59 A59 NNP cord-353298-vr5hnzp8 38 19 ; ; : cord-353298-vr5hnzp8 38 20 MHV MHV NNP cord-353298-vr5hnzp8 38 21 - - HYPH cord-353298-vr5hnzp8 38 22 A59 A59 NNP cord-353298-vr5hnzp8 38 23 ) ) -RRB- cord-353298-vr5hnzp8 38 24 , , , cord-353298-vr5hnzp8 38 25 which which WDT cord-353298-vr5hnzp8 38 26 leads lead VBZ cord-353298-vr5hnzp8 38 27 to to IN cord-353298-vr5hnzp8 38 28 the the DT cord-353298-vr5hnzp8 38 29 development development NN cord-353298-vr5hnzp8 38 30 of of IN cord-353298-vr5hnzp8 38 31 multiple multiple JJ cord-353298-vr5hnzp8 38 32 CNS CNS NNP cord-353298-vr5hnzp8 38 33 demyelinating demyelinating NN cord-353298-vr5hnzp8 38 34 lesions lesion NNS cord-353298-vr5hnzp8 38 35 ( ( -LRB- cord-353298-vr5hnzp8 38 36 Lavi Lavi NNP cord-353298-vr5hnzp8 38 37 et et FW cord-353298-vr5hnzp8 38 38 al al NNP cord-353298-vr5hnzp8 38 39 . . NNP cord-353298-vr5hnzp8 38 40 , , , cord-353298-vr5hnzp8 38 41 1984 1984 CD cord-353298-vr5hnzp8 38 42 ; ; . cord-353298-vr5hnzp8 39 1 Jordan Jordan NNP cord-353298-vr5hnzp8 39 2 et et NNP cord-353298-vr5hnzp8 39 3 al al NNP cord-353298-vr5hnzp8 39 4 . . NNP cord-353298-vr5hnzp8 39 5 , , , cord-353298-vr5hnzp8 39 6 1989 1989 CD cord-353298-vr5hnzp8 39 7 ) ) -RRB- cord-353298-vr5hnzp8 39 8 . . . cord-353298-vr5hnzp8 40 1 This this DT cord-353298-vr5hnzp8 40 2 coronavirus coronavirus NN cord-353298-vr5hnzp8 40 3 replicates replicate VBZ cord-353298-vr5hnzp8 40 4 in in IN cord-353298-vr5hnzp8 40 5 glial glial JJ cord-353298-vr5hnzp8 40 6 cells cell NNS cord-353298-vr5hnzp8 40 7 during during IN cord-353298-vr5hnzp8 40 8 an an DT cord-353298-vr5hnzp8 40 9 early early JJ cord-353298-vr5hnzp8 40 10 phase phase NN cord-353298-vr5hnzp8 40 11 of of IN cord-353298-vr5hnzp8 40 12 the the DT cord-353298-vr5hnzp8 40 13 disease disease NN cord-353298-vr5hnzp8 40 14 and and CC cord-353298-vr5hnzp8 40 15 is be VBZ cord-353298-vr5hnzp8 40 16 subsequently subsequently RB cord-353298-vr5hnzp8 40 17 cleared clear VBN cord-353298-vr5hnzp8 40 18 from from IN cord-353298-vr5hnzp8 40 19 the the DT cord-353298-vr5hnzp8 40 20 CNS CNS NNP cord-353298-vr5hnzp8 40 21 ( ( -LRB- cord-353298-vr5hnzp8 40 22 Jordan Jordan NNP cord-353298-vr5hnzp8 40 23 et et NNP cord-353298-vr5hnzp8 40 24 al al NNP cord-353298-vr5hnzp8 40 25 . . NNP cord-353298-vr5hnzp8 40 26 , , , cord-353298-vr5hnzp8 40 27 1989 1989 CD cord-353298-vr5hnzp8 40 28 ) ) -RRB- cord-353298-vr5hnzp8 40 29 . . . cord-353298-vr5hnzp8 41 1 Infected infected JJ cord-353298-vr5hnzp8 41 2 mice mouse NNS cord-353298-vr5hnzp8 41 3 exhibit exhibit VBP cord-353298-vr5hnzp8 41 4 clinical clinical JJ cord-353298-vr5hnzp8 41 5 signs sign NNS cord-353298-vr5hnzp8 41 6 of of IN cord-353298-vr5hnzp8 41 7 CNS CNS NNP cord-353298-vr5hnzp8 41 8 demyelin demyelin NN cord-353298-vr5hnzp8 41 9 - - HYPH cord-353298-vr5hnzp8 41 10 ation ation NN cord-353298-vr5hnzp8 41 11 within within IN cord-353298-vr5hnzp8 41 12 the the DT cord-353298-vr5hnzp8 41 13 first first JJ cord-353298-vr5hnzp8 41 14 week week NN cord-353298-vr5hnzp8 41 15 post post NN cord-353298-vr5hnzp8 41 16 infection infection NN cord-353298-vr5hnzp8 41 17 ( ( -LRB- cord-353298-vr5hnzp8 41 18 wpi wpi NN cord-353298-vr5hnzp8 41 19 ) ) -RRB- cord-353298-vr5hnzp8 41 20 ? ? . cord-353298-vr5hnzp8 42 1 By by IN cord-353298-vr5hnzp8 42 2 3 3 CD cord-353298-vr5hnzp8 42 3 - - SYM cord-353298-vr5hnzp8 42 4 5 5 CD cord-353298-vr5hnzp8 42 5 wpi wpi NN cord-353298-vr5hnzp8 42 6 , , , cord-353298-vr5hnzp8 42 7 focal focal JJ cord-353298-vr5hnzp8 42 8 areas area NNS cord-353298-vr5hnzp8 42 9 of of IN cord-353298-vr5hnzp8 42 10 demyelination demyelination NN cord-353298-vr5hnzp8 42 11 are be VBP cord-353298-vr5hnzp8 42 12 present present JJ cord-353298-vr5hnzp8 42 13 throughout throughout IN cord-353298-vr5hnzp8 42 14 the the DT cord-353298-vr5hnzp8 42 15 CNS CNS NNP cord-353298-vr5hnzp8 42 16 , , , cord-353298-vr5hnzp8 42 17 with with IN cord-353298-vr5hnzp8 42 18 prominent prominent JJ cord-353298-vr5hnzp8 42 19 lesions lesion NNS cord-353298-vr5hnzp8 42 20 in in IN cord-353298-vr5hnzp8 42 21 the the DT cord-353298-vr5hnzp8 42 22 spinal spinal JJ cord-353298-vr5hnzp8 42 23 cord cord NN cord-353298-vr5hnzp8 42 24 . . . cord-353298-vr5hnzp8 43 1 In in IN cord-353298-vr5hnzp8 43 2 the the DT cord-353298-vr5hnzp8 43 3 following follow VBG cord-353298-vr5hnzp8 43 4 weeks week NNS cord-353298-vr5hnzp8 43 5 , , , cord-353298-vr5hnzp8 43 6 remyelination remyelination NN cord-353298-vr5hnzp8 43 7 is be VBZ cord-353298-vr5hnzp8 43 8 paralleled parallel VBN cord-353298-vr5hnzp8 43 9 by by IN cord-353298-vr5hnzp8 43 10 functional functional JJ cord-353298-vr5hnzp8 43 11 recovery recovery NN cord-353298-vr5hnzp8 43 12 . . . cord-353298-vr5hnzp8 44 1 Using use VBG cord-353298-vr5hnzp8 44 2 this this DT cord-353298-vr5hnzp8 44 3 model model NN cord-353298-vr5hnzp8 44 4 , , , cord-353298-vr5hnzp8 44 5 we -PRON- PRP cord-353298-vr5hnzp8 44 6 can can MD cord-353298-vr5hnzp8 44 7 analyze analyze VB cord-353298-vr5hnzp8 44 8 the the DT cord-353298-vr5hnzp8 44 9 processes process NNS cord-353298-vr5hnzp8 44 10 involved involve VBN cord-353298-vr5hnzp8 44 11 in in IN cord-353298-vr5hnzp8 44 12 regeneration regeneration NN cord-353298-vr5hnzp8 44 13 of of IN cord-353298-vr5hnzp8 44 14 the the DT cord-353298-vr5hnzp8 44 15 cells cell NNS cord-353298-vr5hnzp8 44 16 that that WDT cord-353298-vr5hnzp8 44 17 form form VBP cord-353298-vr5hnzp8 44 18 CNS CNS NNP cord-353298-vr5hnzp8 44 19 myelin myelin NN cord-353298-vr5hnzp8 44 20 . . . cord-353298-vr5hnzp8 45 1 Myelination myelination NN cord-353298-vr5hnzp8 45 2 in in IN cord-353298-vr5hnzp8 45 3 the the DT cord-353298-vr5hnzp8 45 4 developing develop VBG cord-353298-vr5hnzp8 45 5 CNS CNS NNP cord-353298-vr5hnzp8 45 6 requires require VBZ cord-353298-vr5hnzp8 45 7 the the DT cord-353298-vr5hnzp8 45 8 coordinated coordinated JJ cord-353298-vr5hnzp8 45 9 interaction interaction NN cord-353298-vr5hnzp8 45 10 of of IN cord-353298-vr5hnzp8 45 11 several several JJ cord-353298-vr5hnzp8 45 12 types type NNS cord-353298-vr5hnzp8 45 13 of of IN cord-353298-vr5hnzp8 45 14 glial glial JJ cord-353298-vr5hnzp8 45 15 cells cell NNS cord-353298-vr5hnzp8 45 16 ( ( -LRB- cord-353298-vr5hnzp8 45 17 reviewed review VBN cord-353298-vr5hnzp8 45 18 in in IN cord-353298-vr5hnzp8 45 19 Raine Raine NNP cord-353298-vr5hnzp8 45 20 , , , cord-353298-vr5hnzp8 45 21 1984 1984 CD cord-353298-vr5hnzp8 45 22 ; ; : cord-353298-vr5hnzp8 45 23 Wood Wood NNP cord-353298-vr5hnzp8 45 24 and and CC cord-353298-vr5hnzp8 45 25 Bunge Bunge NNP cord-353298-vr5hnzp8 45 26 , , , cord-353298-vr5hnzp8 45 27 1984 1984 CD cord-353298-vr5hnzp8 45 28 ; ; : cord-353298-vr5hnzp8 45 29 Raft Raft NNP cord-353298-vr5hnzp8 45 30 , , , cord-353298-vr5hnzp8 45 31 1989 1989 CD cord-353298-vr5hnzp8 45 32 ) ) -RRB- cord-353298-vr5hnzp8 45 33 . . . cord-353298-vr5hnzp8 46 1 In in IN cord-353298-vr5hnzp8 46 2 vitro vitro FW cord-353298-vr5hnzp8 46 3 studies study NNS cord-353298-vr5hnzp8 46 4 of of IN cord-353298-vr5hnzp8 46 5 optic optic JJ cord-353298-vr5hnzp8 46 6 nerve nerve NN cord-353298-vr5hnzp8 46 7 from from IN cord-353298-vr5hnzp8 46 8 newborn newborn JJ cord-353298-vr5hnzp8 46 9 rat rat NN cord-353298-vr5hnzp8 46 10 have have VBP cord-353298-vr5hnzp8 46 11 characterized characterize VBN cord-353298-vr5hnzp8 46 12 a a DT cord-353298-vr5hnzp8 46 13 bipotential bipotential NNP cord-353298-vr5hnzp8 46 14 progenitbr progenitbr NNP cord-353298-vr5hnzp8 46 15 cell cell NN cord-353298-vr5hnzp8 46 16 that that WDT cord-353298-vr5hnzp8 46 17 can can MD cord-353298-vr5hnzp8 46 18 give give VB cord-353298-vr5hnzp8 46 19 rise rise NN cord-353298-vr5hnzp8 46 20 to to IN cord-353298-vr5hnzp8 46 21 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 46 22 or or CC cord-353298-vr5hnzp8 46 23 to to TO cord-353298-vr5hnzp8 46 24 type type VB cord-353298-vr5hnzp8 46 25 2 2 CD cord-353298-vr5hnzp8 46 26 astrocytes astrocyte NNS cord-353298-vr5hnzp8 46 27 , , , cord-353298-vr5hnzp8 46 28 ' ' '' cord-353298-vr5hnzp8 46 29 and and CC cord-353298-vr5hnzp8 46 30 is be VBZ cord-353298-vr5hnzp8 46 31 therefore therefore RB cord-353298-vr5hnzp8 46 32 called call VBN cord-353298-vr5hnzp8 46 33 an an DT cord-353298-vr5hnzp8 46 34 oligodendrocyte oligodendrocyte JJ cord-353298-vr5hnzp8 46 35 - - HYPH cord-353298-vr5hnzp8 46 36 type type NN cord-353298-vr5hnzp8 46 37 2 2 CD cord-353298-vr5hnzp8 46 38 astrocyte astrocyte NN cord-353298-vr5hnzp8 46 39 ( ( -LRB- cord-353298-vr5hnzp8 46 40 O-2A O-2A NNP cord-353298-vr5hnzp8 46 41 ) ) -RRB- cord-353298-vr5hnzp8 46 42 progenitor progenitor JJ cord-353298-vr5hnzp8 46 43 cell cell NN cord-353298-vr5hnzp8 46 44 . . . cord-353298-vr5hnzp8 47 1 Type type NN cord-353298-vr5hnzp8 47 2 2 2 CD cord-353298-vr5hnzp8 47 3 astrocytes astrocyte NNS cord-353298-vr5hnzp8 47 4 express express VBP cord-353298-vr5hnzp8 47 5 antigens antigen NNS cord-353298-vr5hnzp8 47 6 that that WDT cord-353298-vr5hnzp8 47 7 are be VBP cord-353298-vr5hnzp8 47 8 also also RB cord-353298-vr5hnzp8 47 9 present present JJ cord-353298-vr5hnzp8 47 10 on on IN cord-353298-vr5hnzp8 47 11 the the DT cord-353298-vr5hnzp8 47 12 surface surface NN cord-353298-vr5hnzp8 47 13 of of IN cord-353298-vr5hnzp8 47 14 O-2A O-2A NNP cord-353298-vr5hnzp8 47 15 progenitor progenitor NN cord-353298-vr5hnzp8 47 16 cells cell NNS cord-353298-vr5hnzp8 47 17 . . . cord-353298-vr5hnzp8 48 1 The the DT cord-353298-vr5hnzp8 48 2 localization localization NN cord-353298-vr5hnzp8 48 3 and and CC cord-353298-vr5hnzp8 48 4 function function NN cord-353298-vr5hnzp8 48 5 of of IN cord-353298-vr5hnzp8 48 6 type type NN cord-353298-vr5hnzp8 48 7 2 2 CD cord-353298-vr5hnzp8 48 8 astrocytes astrocyte NNS cord-353298-vr5hnzp8 48 9 in in IN cord-353298-vr5hnzp8 48 10 vivo vivo NN cord-353298-vr5hnzp8 48 11 is be VBZ cord-353298-vr5hnzp8 48 12 not not RB cord-353298-vr5hnzp8 48 13 clear clear JJ cord-353298-vr5hnzp8 48 14 at at IN cord-353298-vr5hnzp8 48 15 the the DT cord-353298-vr5hnzp8 48 16 present present JJ cord-353298-vr5hnzp8 48 17 time time NN cord-353298-vr5hnzp8 48 18 . . . cord-353298-vr5hnzp8 49 1 Another another DT cord-353298-vr5hnzp8 49 2 type type NN cord-353298-vr5hnzp8 49 3 of of IN cord-353298-vr5hnzp8 49 4 astrocyte astrocyte NN cord-353298-vr5hnzp8 49 5 , , , cord-353298-vr5hnzp8 49 6 called call VBD cord-353298-vr5hnzp8 49 7 the the DT cord-353298-vr5hnzp8 49 8 type type NN cord-353298-vr5hnzp8 49 9 1 1 CD cord-353298-vr5hnzp8 49 10 astrocyte astrocyte NN cord-353298-vr5hnzp8 49 11 ; ; : cord-353298-vr5hnzp8 49 12 appears appear VBZ cord-353298-vr5hnzp8 49 13 before before IN cord-353298-vr5hnzp8 49 14 type type NN cord-353298-vr5hnzp8 49 15 2 2 CD cord-353298-vr5hnzp8 49 16 astrocytes astrocyte NNS cord-353298-vr5hnzp8 49 17 and and CC cord-353298-vr5hnzp8 49 18 arises arise VBZ cord-353298-vr5hnzp8 49 19 from from IN cord-353298-vr5hnzp8 49 20 a a DT cord-353298-vr5hnzp8 49 21 glial glial JJ cord-353298-vr5hnzp8 49 22 precursor precursor NN cord-353298-vr5hnzp8 49 23 distinct distinct JJ cord-353298-vr5hnzp8 49 24 from from IN cord-353298-vr5hnzp8 49 25 the the DT cord-353298-vr5hnzp8 49 26 O-2A O-2A NNP cord-353298-vr5hnzp8 49 27 progenitor progenitor NN cord-353298-vr5hnzp8 49 28 ( ( -LRB- cord-353298-vr5hnzp8 49 29 Raft Raft NNP cord-353298-vr5hnzp8 49 30 et et FW cord-353298-vr5hnzp8 49 31 al al NNP cord-353298-vr5hnzp8 49 32 . . NNP cord-353298-vr5hnzp8 49 33 , , , cord-353298-vr5hnzp8 49 34 1984 1984 CD cord-353298-vr5hnzp8 49 35 ) ) -RRB- cord-353298-vr5hnzp8 49 36 . . . cord-353298-vr5hnzp8 50 1 Type type NN cord-353298-vr5hnzp8 50 2 1 1 CD cord-353298-vr5hnzp8 50 3 astrocytes astrocyte NNS cord-353298-vr5hnzp8 50 4 secrete secrete VBP cord-353298-vr5hnzp8 50 5 growth growth NN cord-353298-vr5hnzp8 50 6 factors factor NNS cord-353298-vr5hnzp8 50 7 that that WDT cord-353298-vr5hnzp8 50 8 affect affect VBP cord-353298-vr5hnzp8 50 9 the the DT cord-353298-vr5hnzp8 50 10 proliferation proliferation NN cord-353298-vr5hnzp8 50 11 , , , cord-353298-vr5hnzp8 50 12 migration migration NN cord-353298-vr5hnzp8 50 13 , , , cord-353298-vr5hnzp8 50 14 and/or and/or CC cord-353298-vr5hnzp8 50 15 differentiation differentiation NN cord-353298-vr5hnzp8 50 16 of of IN cord-353298-vr5hnzp8 50 17 O-2A O-2A NNP cord-353298-vr5hnzp8 50 18 progenitors progenitor NNS cord-353298-vr5hnzp8 50 19 ( ( -LRB- cord-353298-vr5hnzp8 50 20 reviewed review VBN cord-353298-vr5hnzp8 50 21 in in IN cord-353298-vr5hnzp8 50 22 Raft Raft NNP cord-353298-vr5hnzp8 50 23 , , , cord-353298-vr5hnzp8 50 24 1989 1989 CD cord-353298-vr5hnzp8 50 25 ; ; : cord-353298-vr5hnzp8 50 26 Dubois Dubois NNP cord-353298-vr5hnzp8 50 27 - - HYPH cord-353298-vr5hnzp8 50 28 Dalcq Dalcq NNP cord-353298-vr5hnzp8 50 29 and and CC cord-353298-vr5hnzp8 50 30 Armstrong Armstrong NNP cord-353298-vr5hnzp8 50 31 , , , cord-353298-vr5hnzp8 50 32 1990 1990 CD cord-353298-vr5hnzp8 50 33 ) ) -RRB- cord-353298-vr5hnzp8 50 34 . . . cord-353298-vr5hnzp8 51 1 Upon upon IN cord-353298-vr5hnzp8 51 2 maturation maturation NN cord-353298-vr5hnzp8 51 3 , , , cord-353298-vr5hnzp8 51 4 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 51 5 elaborate elaborate VBP cord-353298-vr5hnzp8 51 6 extensive extensive JJ cord-353298-vr5hnzp8 51 7 processes process NNS cord-353298-vr5hnzp8 51 8 which which WDT cord-353298-vr5hnzp8 51 9 wrap wrap VBP cord-353298-vr5hnzp8 51 10 around around IN cord-353298-vr5hnzp8 51 11 CNS CNS NNP cord-353298-vr5hnzp8 51 12 axons axon NNS cord-353298-vr5hnzp8 51 13 to to TO cord-353298-vr5hnzp8 51 14 form form VB cord-353298-vr5hnzp8 51 15 myelin myelin NN cord-353298-vr5hnzp8 51 16 ( ( -LRB- cord-353298-vr5hnzp8 51 17 reviewed review VBN cord-353298-vr5hnzp8 51 18 in in IN cord-353298-vr5hnzp8 51 19 Paine Paine NNP cord-353298-vr5hnzp8 51 20 , , , cord-353298-vr5hnzp8 51 21 1984 1984 CD cord-353298-vr5hnzp8 51 22 ) ) -RRB- cord-353298-vr5hnzp8 51 23 . . . cord-353298-vr5hnzp8 52 1 Perinodal perinodal NN cord-353298-vr5hnzp8 52 2 astrocytes astrocyte NNS cord-353298-vr5hnzp8 52 3 , , , cord-353298-vr5hnzp8 52 4 possibly possibly RB cord-353298-vr5hnzp8 52 5 type type NN cord-353298-vr5hnzp8 52 6 2 2 CD cord-353298-vr5hnzp8 52 7 astrocytes astrocyte NNS cord-353298-vr5hnzp8 52 8 , , , cord-353298-vr5hnzp8 52 9 extend extend VB cord-353298-vr5hnzp8 52 10 processes process NNS cord-353298-vr5hnzp8 52 11 to to IN cord-353298-vr5hnzp8 52 12 nodes node NNS cord-353298-vr5hnzp8 52 13 of of IN cord-353298-vr5hnzp8 52 14 Ranvier Ranvier NNP cord-353298-vr5hnzp8 52 15 , , , cord-353298-vr5hnzp8 52 16 which which WDT cord-353298-vr5hnzp8 52 17 are be VBP cord-353298-vr5hnzp8 52 18 electrically electrically RB cord-353298-vr5hnzp8 52 19 excitable excitable JJ cord-353298-vr5hnzp8 52 20 regions region NNS cord-353298-vr5hnzp8 52 21 of of IN cord-353298-vr5hnzp8 52 22 axons axon NNS cord-353298-vr5hnzp8 52 23 between between IN cord-353298-vr5hnzp8 52 24 adjacent adjacent JJ cord-353298-vr5hnzp8 52 25 myelin myelin NN cord-353298-vr5hnzp8 52 26 sheaths sheath NNS cord-353298-vr5hnzp8 52 27 ( ( -LRB- cord-353298-vr5hnzp8 52 28 ffrench ffrench NNP cord-353298-vr5hnzp8 52 29 - - HYPH cord-353298-vr5hnzp8 52 30 Constant constant JJ cord-353298-vr5hnzp8 52 31 and and CC cord-353298-vr5hnzp8 52 32 Raft Raft NNP cord-353298-vr5hnzp8 52 33 , , , cord-353298-vr5hnzp8 52 34 1986b 1986b CD cord-353298-vr5hnzp8 52 35 ; ; : cord-353298-vr5hnzp8 52 36 ffrench ffrench NNP cord-353298-vr5hnzp8 52 37 - - HYPH cord-353298-vr5hnzp8 52 38 Constant Constant NNP cord-353298-vr5hnzp8 52 39 et et FW cord-353298-vr5hnzp8 52 40 al al NNP cord-353298-vr5hnzp8 52 41 . . NNP cord-353298-vr5hnzp8 52 42 , , , cord-353298-vr5hnzp8 52 43 1986 1986 CD cord-353298-vr5hnzp8 52 44 ) ) -RRB- cord-353298-vr5hnzp8 52 45 . . . cord-353298-vr5hnzp8 53 1 Both both DT cord-353298-vr5hnzp8 53 2 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 53 3 and and CC cord-353298-vr5hnzp8 53 4 perinodal perinodal NN cord-353298-vr5hnzp8 53 5 astrocytes astrocyte NNS cord-353298-vr5hnzp8 53 6 seem seem VBP cord-353298-vr5hnzp8 53 7 to to TO cord-353298-vr5hnzp8 53 8 play play VB cord-353298-vr5hnzp8 53 9 a a DT cord-353298-vr5hnzp8 53 10 role role NN cord-353298-vr5hnzp8 53 11 in in IN cord-353298-vr5hnzp8 53 12 efficient efficient JJ cord-353298-vr5hnzp8 53 13 saltatory saltatory NN cord-353298-vr5hnzp8 53 14 conduction conduction NN cord-353298-vr5hnzp8 53 15 of of IN cord-353298-vr5hnzp8 53 16 nerve nerve NN cord-353298-vr5hnzp8 53 17 impulses impulse NNS cord-353298-vr5hnzp8 53 18 ; ; : cord-353298-vr5hnzp8 53 19 myelin myelin NN cord-353298-vr5hnzp8 53 20 acts act NNS cord-353298-vr5hnzp8 53 21 as as IN cord-353298-vr5hnzp8 53 22 an an DT cord-353298-vr5hnzp8 53 23 electrical electrical JJ cord-353298-vr5hnzp8 53 24 insulator insulator NN cord-353298-vr5hnzp8 53 25 while while IN cord-353298-vr5hnzp8 53 26 perinodal perinodal NNP cord-353298-vr5hnzp8 53 27 astrocytic astrocytic JJ cord-353298-vr5hnzp8 53 28 processes process NNS cord-353298-vr5hnzp8 53 29 may may MD cord-353298-vr5hnzp8 53 30 serve serve VB cord-353298-vr5hnzp8 53 31 various various JJ cord-353298-vr5hnzp8 53 32 functions function NNS cord-353298-vr5hnzp8 53 33 associated associate VBN cord-353298-vr5hnzp8 53 34 with with IN cord-353298-vr5hnzp8 53 35 impulse impulse NN cord-353298-vr5hnzp8 53 36 propagation propagation NN cord-353298-vr5hnzp8 53 37 at at IN cord-353298-vr5hnzp8 53 38 nodes node NNS cord-353298-vr5hnzp8 53 39 ( ( -LRB- cord-353298-vr5hnzp8 53 40 discussed discuss VBN cord-353298-vr5hnzp8 53 41 in in IN cord-353298-vr5hnzp8 53 42 Ritchie Ritchie NNP cord-353298-vr5hnzp8 53 43 , , , cord-353298-vr5hnzp8 53 44 1984 1984 CD cord-353298-vr5hnzp8 53 45 ; ; : cord-353298-vr5hnzp8 53 46 Black Black NNP cord-353298-vr5hnzp8 53 47 and and CC cord-353298-vr5hnzp8 53 48 Waxman Waxman NNP cord-353298-vr5hnzp8 53 49 , , , cord-353298-vr5hnzp8 53 50 1988 1988 CD cord-353298-vr5hnzp8 53 51 ) ) -RRB- cord-353298-vr5hnzp8 53 52 . . . cord-353298-vr5hnzp8 54 1 In in IN cord-353298-vr5hnzp8 54 2 normal normal JJ cord-353298-vr5hnzp8 54 3 adult adult NN cord-353298-vr5hnzp8 54 4 CNS cns NN cord-353298-vr5hnzp8 54 5 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 54 6 proliferate proliferate VBP cord-353298-vr5hnzp8 54 7 minimally minimally RB cord-353298-vr5hnzp8 54 8 ( ( -LRB- cord-353298-vr5hnzp8 54 9 McCarthy McCarthy NNP cord-353298-vr5hnzp8 54 10 and and CC cord-353298-vr5hnzp8 54 11 Leblond Leblond NNP cord-353298-vr5hnzp8 54 12 , , , cord-353298-vr5hnzp8 54 13 1988 1988 CD cord-353298-vr5hnzp8 54 14 ) ) -RRB- cord-353298-vr5hnzp8 54 15 . . . cord-353298-vr5hnzp8 55 1 Attempts attempt NNS cord-353298-vr5hnzp8 55 2 to to TO cord-353298-vr5hnzp8 55 3 induce induce VB cord-353298-vr5hnzp8 55 4 in in IN cord-353298-vr5hnzp8 55 5 vitro vitro FW cord-353298-vr5hnzp8 55 6 mitosis mitosis NN cord-353298-vr5hnzp8 55 7 of of IN cord-353298-vr5hnzp8 55 8 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 55 9 with with IN cord-353298-vr5hnzp8 55 10 exogenous exogenous JJ cord-353298-vr5hnzp8 55 11 growth growth NN cord-353298-vr5hnzp8 55 12 factors factor NNS cord-353298-vr5hnzp8 55 13 have have VBP cord-353298-vr5hnzp8 55 14 not not RB cord-353298-vr5hnzp8 55 15 been be VBN cord-353298-vr5hnzp8 55 16 successful successful JJ cord-353298-vr5hnzp8 56 1 ( ( -LRB- cord-353298-vr5hnzp8 56 2 Yong Yong NNP cord-353298-vr5hnzp8 56 3 et et NNP cord-353298-vr5hnzp8 56 4 al al NNP cord-353298-vr5hnzp8 56 5 . . NNP cord-353298-vr5hnzp8 56 6 , , , cord-353298-vr5hnzp8 56 7 1988 1988 CD cord-353298-vr5hnzp8 56 8 ) ) -RRB- cord-353298-vr5hnzp8 56 9 . . . cord-353298-vr5hnzp8 57 1 However however RB cord-353298-vr5hnzp8 57 2 , , , cord-353298-vr5hnzp8 57 3 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 57 4 isolated isolate VBN cord-353298-vr5hnzp8 57 5 from from IN cord-353298-vr5hnzp8 57 6 adult adult NN cord-353298-vr5hnzp8 57 7 CNS CNS NNP cord-353298-vr5hnzp8 57 8 do do VBP cord-353298-vr5hnzp8 57 9 proliferate proliferate VB cord-353298-vr5hnzp8 57 10 when when WRB cord-353298-vr5hnzp8 57 11 cocultured coculture VBN cord-353298-vr5hnzp8 57 12 with with IN cord-353298-vr5hnzp8 57 13 neurons neuron NNS cord-353298-vr5hnzp8 57 14 ( ( -LRB- cord-353298-vr5hnzp8 57 15 Wood Wood NNP cord-353298-vr5hnzp8 57 16 and and CC cord-353298-vr5hnzp8 57 17 Bunge Bunge NNP cord-353298-vr5hnzp8 57 18 , , , cord-353298-vr5hnzp8 57 19 1986 1986 CD cord-353298-vr5hnzp8 57 20 ) ) -RRB- cord-353298-vr5hnzp8 57 21 . . . cord-353298-vr5hnzp8 58 1 In in IN cord-353298-vr5hnzp8 58 2 addition addition NN cord-353298-vr5hnzp8 58 3 , , , cord-353298-vr5hnzp8 58 4 O-2A O-2A NNP cord-353298-vr5hnzp8 58 5 progenitor progenitor NN cord-353298-vr5hnzp8 58 6 cells cell NNS cord-353298-vr5hnzp8 58 7 isolated isolate VBN cord-353298-vr5hnzp8 58 8 from from IN cord-353298-vr5hnzp8 58 9 adult adult NN cord-353298-vr5hnzp8 58 10 rat rat NN cord-353298-vr5hnzp8 58 11 optic optic JJ cord-353298-vr5hnzp8 58 12 nerve nerve NN cord-353298-vr5hnzp8 58 13 are be VBP cord-353298-vr5hnzp8 58 14 capable capable JJ cord-353298-vr5hnzp8 58 15 of of IN cord-353298-vr5hnzp8 58 16 proliferating proliferate VBG cord-353298-vr5hnzp8 58 17 in in IN cord-353298-vr5hnzp8 58 18 vitro vitro FW cord-353298-vr5hnzp8 58 19 in in IN cord-353298-vr5hnzp8 58 20 the the DT cord-353298-vr5hnzp8 58 21 absence absence NN cord-353298-vr5hnzp8 58 22 of of IN cord-353298-vr5hnzp8 58 23 neurons neuron NNS cord-353298-vr5hnzp8 58 24 and and CC cord-353298-vr5hnzp8 58 25 maintain maintain VB cord-353298-vr5hnzp8 58 26 the the DT cord-353298-vr5hnzp8 58 27 ability ability NN cord-353298-vr5hnzp8 58 28 to to TO cord-353298-vr5hnzp8 58 29 differentiate differentiate VB cord-353298-vr5hnzp8 58 30 ( ( -LRB- cord-353298-vr5hnzp8 58 31 ffrench ffrench NNP cord-353298-vr5hnzp8 58 32 - - HYPH cord-353298-vr5hnzp8 58 33 Constant constant JJ cord-353298-vr5hnzp8 58 34 and and CC cord-353298-vr5hnzp8 58 35 Raft Raft NNP cord-353298-vr5hnzp8 58 36 , , , cord-353298-vr5hnzp8 58 37 1986a 1986a CD cord-353298-vr5hnzp8 58 38 ; ; : cord-353298-vr5hnzp8 58 39 Wolswijk Wolswijk NNP cord-353298-vr5hnzp8 58 40 and and CC cord-353298-vr5hnzp8 58 41 Noble Noble NNP cord-353298-vr5hnzp8 58 42 , , , cord-353298-vr5hnzp8 58 43 1989 1989 CD cord-353298-vr5hnzp8 58 44 ) ) -RRB- cord-353298-vr5hnzp8 58 45 . . . cord-353298-vr5hnzp8 59 1 These these DT cord-353298-vr5hnzp8 59 2 studies study NNS cord-353298-vr5hnzp8 59 3 provide provide VBP cord-353298-vr5hnzp8 59 4 evidence evidence NN cord-353298-vr5hnzp8 59 5 that that IN cord-353298-vr5hnzp8 59 6 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 59 7 and/or and/or CC cord-353298-vr5hnzp8 59 8 O-2A O-2A NNP cord-353298-vr5hnzp8 59 9 progenitor progenitor NN cord-353298-vr5hnzp8 59 10 cells cell NNS cord-353298-vr5hnzp8 59 11 may may MD cord-353298-vr5hnzp8 59 12 contribute contribute VB cord-353298-vr5hnzp8 59 13 to to IN cord-353298-vr5hnzp8 59 14 the the DT cord-353298-vr5hnzp8 59 15 regeneration regeneration NN cord-353298-vr5hnzp8 59 16 of of IN cord-353298-vr5hnzp8 59 17 O-2A O-2A NNP cord-353298-vr5hnzp8 59 18 lineage lineage NN cord-353298-vr5hnzp8 59 19 cells cell NNS cord-353298-vr5hnzp8 59 20 in in IN cord-353298-vr5hnzp8 59 21 the the DT cord-353298-vr5hnzp8 59 22 adult adult NN cord-353298-vr5hnzp8 59 23 CNS CNS NNP cord-353298-vr5hnzp8 59 24 . . . cord-353298-vr5hnzp8 60 1 After after IN cord-353298-vr5hnzp8 60 2 widespread widespread JJ cord-353298-vr5hnzp8 60 3 CNS CNS NNP cord-353298-vr5hnzp8 60 4 demyelination demyelination NN cord-353298-vr5hnzp8 60 5 , , , cord-353298-vr5hnzp8 60 6 surviving survive VBG cord-353298-vr5hnzp8 60 7 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 60 8 at at IN cord-353298-vr5hnzp8 60 9 the the DT cord-353298-vr5hnzp8 60 10 periphery periphery NN cord-353298-vr5hnzp8 60 11 of of IN cord-353298-vr5hnzp8 60 12 lesions lesion NNS cord-353298-vr5hnzp8 60 13 do do VBP cord-353298-vr5hnzp8 60 14 not not RB cord-353298-vr5hnzp8 60 15 seem seem VB cord-353298-vr5hnzp8 60 16 to to TO cord-353298-vr5hnzp8 60 17 be be VB cord-353298-vr5hnzp8 60 18 able able JJ cord-353298-vr5hnzp8 60 19 to to TO cord-353298-vr5hnzp8 60 20 elaborate elaborate VB cord-353298-vr5hnzp8 60 21 myelinating myelinating NN cord-353298-vr5hnzp8 60 22 processes process NNS cord-353298-vr5hnzp8 60 23 and/or and/or CC cord-353298-vr5hnzp8 60 24 relocate relocate VB cord-353298-vr5hnzp8 60 25 to to TO cord-353298-vr5hnzp8 60 26 achieve achieve VB cord-353298-vr5hnzp8 60 27 efficient efficient JJ cord-353298-vr5hnzp8 60 28 remyelination remyelination NN cord-353298-vr5hnzp8 60 29 . . . cord-353298-vr5hnzp8 61 1 Proliferation proliferation NN cord-353298-vr5hnzp8 61 2 of of IN cord-353298-vr5hnzp8 61 3 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 61 4 , , , cord-353298-vr5hnzp8 61 5 or or CC cord-353298-vr5hnzp8 61 6 oligodendrocTte oligodendroctte CD cord-353298-vr5hnzp8 61 7 precursor precursor NN cord-353298-vr5hnzp8 61 8 cells cell NNS cord-353298-vr5hnzp8 61 9 , , , cord-353298-vr5hnzp8 61 10 during during IN cord-353298-vr5hnzp8 61 11 demyelination demyelination NN cord-353298-vr5hnzp8 61 12 appears appear VBZ cord-353298-vr5hnzp8 61 13 to to TO cord-353298-vr5hnzp8 61 14 be be VB cord-353298-vr5hnzp8 61 15 necessary necessary JJ cord-353298-vr5hnzp8 61 16 to to TO cord-353298-vr5hnzp8 61 17 facilitate facilitate VB cord-353298-vr5hnzp8 61 18 remyelination remyelination NN cord-353298-vr5hnzp8 61 19 . . . cord-353298-vr5hnzp8 62 1 Electron electron NN cord-353298-vr5hnzp8 62 2 microscopic microscopic JJ cord-353298-vr5hnzp8 62 3 autoradiographic autoradiographic JJ cord-353298-vr5hnzp8 62 4 analyses analysis NNS cord-353298-vr5hnzp8 62 5 of of IN cord-353298-vr5hnzp8 62 6 demyelinating demyelinate VBG cord-353298-vr5hnzp8 62 7 tissue tissue NN cord-353298-vr5hnzp8 62 8 have have VBP cord-353298-vr5hnzp8 62 9 reported report VBN cord-353298-vr5hnzp8 62 10 mitosis mitosis NN cord-353298-vr5hnzp8 62 11 of of IN cord-353298-vr5hnzp8 62 12 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 62 13 at at IN cord-353298-vr5hnzp8 62 14 several several JJ cord-353298-vr5hnzp8 62 15 stages stage NNS cord-353298-vr5hnzp8 62 16 of of IN cord-353298-vr5hnzp8 62 17 maturation maturation NN cord-353298-vr5hnzp8 62 18 ( ( -LRB- cord-353298-vr5hnzp8 62 19 Herndon Herndon NNP cord-353298-vr5hnzp8 62 20 et et NNP cord-353298-vr5hnzp8 62 21 al al NNP cord-353298-vr5hnzp8 62 22 . . NNP cord-353298-vr5hnzp8 62 23 , , , cord-353298-vr5hnzp8 62 24 1977 1977 CD cord-353298-vr5hnzp8 62 25 ; ; : cord-353298-vr5hnzp8 62 26 Ludwin Ludwin NNP cord-353298-vr5hnzp8 62 27 , , , cord-353298-vr5hnzp8 62 28 1979 1979 CD cord-353298-vr5hnzp8 62 29 ; ; : cord-353298-vr5hnzp8 62 30 Aranella Aranella NNP cord-353298-vr5hnzp8 62 31 and and CC cord-353298-vr5hnzp8 62 32 Herndon Herndon NNP cord-353298-vr5hnzp8 62 33 , , , cord-353298-vr5hnzp8 62 34 1984 1984 CD cord-353298-vr5hnzp8 62 35 ; ; : cord-353298-vr5hnzp8 62 36 Ludwin Ludwin NNP cord-353298-vr5hnzp8 62 37 and and CC cord-353298-vr5hnzp8 62 38 Bakker Bakker NNP cord-353298-vr5hnzp8 62 39 , , , cord-353298-vr5hnzp8 62 40 1988 1988 CD cord-353298-vr5hnzp8 62 41 ) ) -RRB- cord-353298-vr5hnzp8 62 42 . . . cord-353298-vr5hnzp8 63 1 A a DT cord-353298-vr5hnzp8 63 2 recent recent JJ cord-353298-vr5hnzp8 63 3 in in IN cord-353298-vr5hnzp8 63 4 vivo vivo NN cord-353298-vr5hnzp8 63 5 analysis analysis NN cord-353298-vr5hnzp8 63 6 combining combine VBG cord-353298-vr5hnzp8 63 7 immunolabeling immunolabele VBG cord-353298-vr5hnzp8 63 8 with with IN cord-353298-vr5hnzp8 63 9 autoradiography autoradiography NNP cord-353298-vr5hnzp8 63 10 has have VBZ cord-353298-vr5hnzp8 63 11 shown show VBN cord-353298-vr5hnzp8 63 12 that that IN cord-353298-vr5hnzp8 63 13 O-2A O-2A NNP cord-353298-vr5hnzp8 63 14 progenitor progenitor NN cord-353298-vr5hnzp8 63 15 cells cell NNS cord-353298-vr5hnzp8 63 16 and and CC cord-353298-vr5hnzp8 63 17 astrocytes astrocyte NNS cord-353298-vr5hnzp8 63 18 that that WDT cord-353298-vr5hnzp8 63 19 express express VBP cord-353298-vr5hnzp8 63 20 04 04 CD cord-353298-vr5hnzp8 63 21 antigens antigen NNS cord-353298-vr5hnzp8 63 22 proliferate proliferate VBP cord-353298-vr5hnzp8 63 23 early early RB cord-353298-vr5hnzp8 63 24 in in IN cord-353298-vr5hnzp8 63 25 the the DT cord-353298-vr5hnzp8 63 26 course course NN cord-353298-vr5hnzp8 63 27 of of IN cord-353298-vr5hnzp8 63 28 demyelination demyelination NN cord-353298-vr5hnzp8 63 29 induced induce VBN cord-353298-vr5hnzp8 63 30 by by IN cord-353298-vr5hnzp8 63 31 coronavirus coronavirus NN cord-353298-vr5hnzp8 63 32 infection infection NN cord-353298-vr5hnzp8 63 33 and and CC cord-353298-vr5hnzp8 63 34 that that IN cord-353298-vr5hnzp8 63 35 some some DT cord-353298-vr5hnzp8 63 36 cells cell NNS cord-353298-vr5hnzp8 63 37 generated generate VBN cord-353298-vr5hnzp8 63 38 during during IN cord-353298-vr5hnzp8 63 39 demyelination demyelination NN cord-353298-vr5hnzp8 63 40 later later RB cord-353298-vr5hnzp8 63 41 became become VBD cord-353298-vr5hnzp8 63 42 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 63 43 ( ( -LRB- cord-353298-vr5hnzp8 63 44 Godfraind Godfraind NNP cord-353298-vr5hnzp8 63 45 et et NNP cord-353298-vr5hnzp8 63 46 al al NNP cord-353298-vr5hnzp8 63 47 . . NNP cord-353298-vr5hnzp8 63 48 , , , cord-353298-vr5hnzp8 63 49 1989 1989 CD cord-353298-vr5hnzp8 63 50 ) ) -RRB- cord-353298-vr5hnzp8 63 51 . . . cord-353298-vr5hnzp8 64 1 In in IN cord-353298-vr5hnzp8 64 2 the the DT cord-353298-vr5hnzp8 64 3 present present JJ cord-353298-vr5hnzp8 64 4 study study NN cord-353298-vr5hnzp8 64 5 , , , cord-353298-vr5hnzp8 64 6 we -PRON- PRP cord-353298-vr5hnzp8 64 7 have have VBP cord-353298-vr5hnzp8 64 8 developed develop VBN cord-353298-vr5hnzp8 64 9 an an DT cord-353298-vr5hnzp8 64 10 in in IN cord-353298-vr5hnzp8 64 11 vitro vitro FW cord-353298-vr5hnzp8 64 12 system system NN cord-353298-vr5hnzp8 64 13 to to TO cord-353298-vr5hnzp8 64 14 further further RB cord-353298-vr5hnzp8 64 15 characterize characterize VB cord-353298-vr5hnzp8 64 16 the the DT cord-353298-vr5hnzp8 64 17 cells cell NNS cord-353298-vr5hnzp8 64 18 involved involve VBN cord-353298-vr5hnzp8 64 19 in in IN cord-353298-vr5hnzp8 64 20 the the DT cord-353298-vr5hnzp8 64 21 remyelination remyelination NN cord-353298-vr5hnzp8 64 22 process process NN cord-353298-vr5hnzp8 64 23 . . . cord-353298-vr5hnzp8 65 1 We -PRON- PRP cord-353298-vr5hnzp8 65 2 have have VBP cord-353298-vr5hnzp8 65 3 used use VBN cord-353298-vr5hnzp8 65 4 threecolor threecolor NN cord-353298-vr5hnzp8 65 5 immunofluorescence immunofluorescence NN cord-353298-vr5hnzp8 65 6 combined combine VBN cord-353298-vr5hnzp8 65 7 with with IN cord-353298-vr5hnzp8 65 8 autoradiography autoradiography NNP cord-353298-vr5hnzp8 65 9 to to TO cord-353298-vr5hnzp8 65 10 identify identify VB cord-353298-vr5hnzp8 65 11 specific specific JJ cord-353298-vr5hnzp8 65 12 glial glial JJ cord-353298-vr5hnzp8 65 13 cell cell NN cord-353298-vr5hnzp8 65 14 types type NNS cord-353298-vr5hnzp8 65 15 . . . cord-353298-vr5hnzp8 66 1 In in IN cord-353298-vr5hnzp8 66 2 such such PDT cord-353298-vr5hnzp8 66 3 a a DT cord-353298-vr5hnzp8 66 4 system system NN cord-353298-vr5hnzp8 66 5 we -PRON- PRP cord-353298-vr5hnzp8 66 6 can can MD cord-353298-vr5hnzp8 66 7 analyze analyze VB cord-353298-vr5hnzp8 66 8 the the DT cord-353298-vr5hnzp8 66 9 proliferative proliferative JJ cord-353298-vr5hnzp8 66 10 capacity capacity NN cord-353298-vr5hnzp8 66 11 , , , cord-353298-vr5hnzp8 66 12 phenotypic phenotypic JJ cord-353298-vr5hnzp8 66 13 plasticity plasticity NN cord-353298-vr5hnzp8 66 14 , , , cord-353298-vr5hnzp8 66 15 and and CC cord-353298-vr5hnzp8 66 16 differentiation differentiation NN cord-353298-vr5hnzp8 66 17 potential potential NN cord-353298-vr5hnzp8 66 18 of of IN cord-353298-vr5hnzp8 66 19 the the DT cord-353298-vr5hnzp8 66 20 various various JJ cord-353298-vr5hnzp8 66 21 types type NNS cord-353298-vr5hnzp8 66 22 of of IN cord-353298-vr5hnzp8 66 23 glial glial JJ cord-353298-vr5hnzp8 66 24 cells cell NNS cord-353298-vr5hnzp8 66 25 which which WDT cord-353298-vr5hnzp8 66 26 may may MD cord-353298-vr5hnzp8 66 27 play play VB cord-353298-vr5hnzp8 66 28 a a DT cord-353298-vr5hnzp8 66 29 key key JJ cord-353298-vr5hnzp8 66 30 role role NN cord-353298-vr5hnzp8 66 31 in in IN cord-353298-vr5hnzp8 66 32 CNS CNS NNP cord-353298-vr5hnzp8 66 33 remyelination remyelination NN cord-353298-vr5hnzp8 66 34 . . . cord-353298-vr5hnzp8 67 1 Female female JJ cord-353298-vr5hnzp8 67 2 C57B1/6N C57B1/6N NNP cord-353298-vr5hnzp8 67 3 mice mouse NNS cord-353298-vr5hnzp8 67 4 , , , cord-353298-vr5hnzp8 67 5 without without IN cord-353298-vr5hnzp8 67 6 prior prior JJ cord-353298-vr5hnzp8 67 7 exposure exposure NN cord-353298-vr5hnzp8 67 8 to to IN cord-353298-vr5hnzp8 67 9 MHV MHV NNP cord-353298-vr5hnzp8 67 10 - - HYPH cord-353298-vr5hnzp8 67 11 A59 A59 NNP cord-353298-vr5hnzp8 67 12 , , , cord-353298-vr5hnzp8 67 13 were be VBD cord-353298-vr5hnzp8 67 14 obtained obtain VBN cord-353298-vr5hnzp8 67 15 from from IN cord-353298-vr5hnzp8 67 16 the the DT cord-353298-vr5hnzp8 67 17 Frederick Frederick NNP cord-353298-vr5hnzp8 67 18 Cancer Cancer NNP cord-353298-vr5hnzp8 67 19 Research Research NNP cord-353298-vr5hnzp8 67 20 Facility Facility NNP cord-353298-vr5hnzp8 67 21 ( ( -LRB- cord-353298-vr5hnzp8 67 22 Frederick Frederick NNP cord-353298-vr5hnzp8 67 23 , , , cord-353298-vr5hnzp8 67 24 MD MD NNP cord-353298-vr5hnzp8 67 25 ) ) -RRB- cord-353298-vr5hnzp8 67 26 . . . cord-353298-vr5hnzp8 68 1 At at IN cord-353298-vr5hnzp8 68 2 28 28 CD cord-353298-vr5hnzp8 68 3 d d NN cord-353298-vr5hnzp8 68 4 of of IN cord-353298-vr5hnzp8 68 5 age age NN cord-353298-vr5hnzp8 68 6 each each DT cord-353298-vr5hnzp8 68 7 mouse mouse NN cord-353298-vr5hnzp8 68 8 was be VBD cord-353298-vr5hnzp8 68 9 injected inject VBN cord-353298-vr5hnzp8 68 10 intracranially intracranially RB cord-353298-vr5hnzp8 68 11 with with IN cord-353298-vr5hnzp8 68 12 1,000 1,000 CD cord-353298-vr5hnzp8 68 13 plaqueforming plaqueforming NN cord-353298-vr5hnzp8 68 14 units unit NNS cord-353298-vr5hnzp8 68 15 of of IN cord-353298-vr5hnzp8 68 16 coronavirus coronavirus NN cord-353298-vr5hnzp8 68 17 ( ( -LRB- cord-353298-vr5hnzp8 68 18 MI MI NNP cord-353298-vr5hnzp8 68 19 - - HYPH cord-353298-vr5hnzp8 68 20 IV IV NNP cord-353298-vr5hnzp8 68 21 - - HYPH cord-353298-vr5hnzp8 68 22 A59 A59 NNP cord-353298-vr5hnzp8 68 23 ) ) -RRB- cord-353298-vr5hnzp8 68 24 , , , cord-353298-vr5hnzp8 68 25 which which WDT cord-353298-vr5hnzp8 68 26 had have VBD cord-353298-vr5hnzp8 68 27 been be VBN cord-353298-vr5hnzp8 68 28 propagated propagate VBN cord-353298-vr5hnzp8 68 29 in in IN cord-353298-vr5hnzp8 68 30 the the DT cord-353298-vr5hnzp8 68 31 17 17 CD cord-353298-vr5hnzp8 68 32 CI CI NNP cord-353298-vr5hnzp8 68 33 1 1 CD cord-353298-vr5hnzp8 68 34 line line NN cord-353298-vr5hnzp8 68 35 of of IN cord-353298-vr5hnzp8 68 36 spontaneously spontaneously RB cord-353298-vr5hnzp8 68 37 transformed transform VBN cord-353298-vr5hnzp8 68 38 BALB BALB NNP cord-353298-vr5hnzp8 68 39 / / SYM cord-353298-vr5hnzp8 68 40 c c NN cord-353298-vr5hnzp8 68 41 3T3 3t3 CD cord-353298-vr5hnzp8 68 42 cells cell NNS cord-353298-vr5hnzp8 68 43 ( ( -LRB- cord-353298-vr5hnzp8 68 44 Sturman Sturman NNP cord-353298-vr5hnzp8 68 45 et et NNP cord-353298-vr5hnzp8 68 46 al al NNP cord-353298-vr5hnzp8 68 47 . . NNP cord-353298-vr5hnzp8 68 48 , , , cord-353298-vr5hnzp8 68 49 1980 1980 CD cord-353298-vr5hnzp8 68 50 ) ) -RRB- cord-353298-vr5hnzp8 68 51 . . . cord-353298-vr5hnzp8 69 1 This this DT cord-353298-vr5hnzp8 69 2 age age NN cord-353298-vr5hnzp8 69 3 and and CC cord-353298-vr5hnzp8 69 4 inoculation inoculation NN cord-353298-vr5hnzp8 69 5 dosage dosage NN cord-353298-vr5hnzp8 69 6 op op NN cord-353298-vr5hnzp8 69 7 " " '' cord-353298-vr5hnzp8 69 8 ttmized ttmize VBD cord-353298-vr5hnzp8 69 9 the the DT cord-353298-vr5hnzp8 69 10 proportion proportion NN cord-353298-vr5hnzp8 69 11 of of IN cord-353298-vr5hnzp8 69 12 mice mouse NNS cord-353298-vr5hnzp8 69 13 developing develop VBG cord-353298-vr5hnzp8 69 14 demyelinating demyelinating JJ cord-353298-vr5hnzp8 69 15 lesions lesion NNS cord-353298-vr5hnzp8 69 16 ( ( -LRB- cord-353298-vr5hnzp8 69 17 ' ' '' cord-353298-vr5hnzp8 69 18 069 069 CD cord-353298-vr5hnzp8 69 19 % % NN cord-353298-vr5hnzp8 69 20 ) ) -RRB- cord-353298-vr5hnzp8 70 1 relative relative JJ cord-353298-vr5hnzp8 70 2 to to IN cord-353298-vr5hnzp8 70 3 the the DT cord-353298-vr5hnzp8 70 4 incidence incidence NN cord-353298-vr5hnzp8 70 5 of of IN cord-353298-vr5hnzp8 70 6 acute acute JJ cord-353298-vr5hnzp8 70 7 mortality mortality NN cord-353298-vr5hnzp8 70 8 ( ( -LRB- cord-353298-vr5hnzp8 70 9 , , , cord-353298-vr5hnzp8 70 10 o11 o11 CD cord-353298-vr5hnzp8 70 11 % % NN cord-353298-vr5hnzp8 70 12 ) ) -RRB- cord-353298-vr5hnzp8 70 13 . . . cord-353298-vr5hnzp8 71 1 At at IN cord-353298-vr5hnzp8 71 2 1 1 CD cord-353298-vr5hnzp8 71 3 , , , cord-353298-vr5hnzp8 71 4 3 3 CD cord-353298-vr5hnzp8 71 5 , , , cord-353298-vr5hnzp8 71 6 4 4 CD cord-353298-vr5hnzp8 71 7 , , , cord-353298-vr5hnzp8 71 8 5 5 CD cord-353298-vr5hnzp8 71 9 , , , cord-353298-vr5hnzp8 71 10 or or CC cord-353298-vr5hnzp8 71 11 8 8 CD cord-353298-vr5hnzp8 71 12 wpi wpi NN cord-353298-vr5hnzp8 71 13 , , , cord-353298-vr5hnzp8 71 14 mice mouse NNS cord-353298-vr5hnzp8 71 15 were be VBD cord-353298-vr5hnzp8 71 16 anesthetized anesthetize VBN cord-353298-vr5hnzp8 71 17 with with IN cord-353298-vr5hnzp8 71 18 methoxyflurane methoxyflurane NNP cord-353298-vr5hnzp8 71 19 and and CC cord-353298-vr5hnzp8 71 20 then then RB cord-353298-vr5hnzp8 71 21 decapitated decapitate VBN cord-353298-vr5hnzp8 71 22 . . . cord-353298-vr5hnzp8 72 1 For for IN cord-353298-vr5hnzp8 72 2 each each DT cord-353298-vr5hnzp8 72 3 glial glial JJ cord-353298-vr5hnzp8 72 4 cell cell NN cord-353298-vr5hnzp8 72 5 isolation isolation NN cord-353298-vr5hnzp8 72 6 , , , cord-353298-vr5hnzp8 72 7 spinal spinal JJ cord-353298-vr5hnzp8 72 8 cords cord NNS cord-353298-vr5hnzp8 72 9 remov&t remov&t '' cord-353298-vr5hnzp8 72 10 from from IN cord-353298-vr5hnzp8 72 11 three three CD cord-353298-vr5hnzp8 72 12 infected infected JJ cord-353298-vr5hnzp8 72 13 mice mouse NNS cord-353298-vr5hnzp8 72 14 exhibiting exhibit VBG cord-353298-vr5hnzp8 72 15 neurological neurological JJ cord-353298-vr5hnzp8 72 16 dysfunction dysfunction NN cord-353298-vr5hnzp8 73 1 ( ( -LRB- cord-353298-vr5hnzp8 73 2 Woyciechowska Woyciechowska NNP cord-353298-vr5hnzp8 73 3 et et NNP cord-353298-vr5hnzp8 73 4 al al NNP cord-353298-vr5hnzp8 73 5 . . NNP cord-353298-vr5hnzp8 73 6 , , , cord-353298-vr5hnzp8 73 7 1984 1984 CD cord-353298-vr5hnzp8 73 8 ) ) -RRB- cord-353298-vr5hnzp8 73 9 were be VBD cord-353298-vr5hnzp8 73 10 combined combine VBN cord-353298-vr5hnzp8 73 11 and and CC cord-353298-vr5hnzp8 73 12 spinal spinal JJ cord-353298-vr5hnzp8 73 13 cord cord NN cord-353298-vr5hnzp8 73 14 tissue tissue NN cord-353298-vr5hnzp8 73 15 from from IN cord-353298-vr5hnzp8 73 16 three three CD cord-353298-vr5hnzp8 73 17 age age NN cord-353298-vr5hnzp8 73 18 - - HYPH cord-353298-vr5hnzp8 73 19 matched match VBN cord-353298-vr5hnzp8 73 20 control control NN cord-353298-vr5hnzp8 73 21 mice mouse NNS cord-353298-vr5hnzp8 73 22 was be VBD cord-353298-vr5hnzp8 73 23 prepared prepare VBN cord-353298-vr5hnzp8 73 24 simultaneously simultaneously RB cord-353298-vr5hnzp8 73 25 . . . cord-353298-vr5hnzp8 74 1 Spinal spinal JJ cord-353298-vr5hnzp8 74 2 cords cord NNS cord-353298-vr5hnzp8 74 3 were be VBD cord-353298-vr5hnzp8 74 4 minced mince VBN cord-353298-vr5hnzp8 74 5 and and CC cord-353298-vr5hnzp8 74 6 then then RB cord-353298-vr5hnzp8 74 7 dissociated dissociate VBN cord-353298-vr5hnzp8 74 8 according accord VBG cord-353298-vr5hnzp8 74 9 to to IN cord-353298-vr5hnzp8 74 10 a a DT cord-353298-vr5hnzp8 74 11 procedure procedure NN cord-353298-vr5hnzp8 74 12 modified modify VBN cord-353298-vr5hnzp8 74 13 from from IN cord-353298-vr5hnzp8 74 14 Miller Miller NNP cord-353298-vr5hnzp8 74 15 et et NNP cord-353298-vr5hnzp8 74 16 al al NNP cord-353298-vr5hnzp8 74 17 . . . cord-353298-vr5hnzp8 75 1 ( ( -LRB- cord-353298-vr5hnzp8 75 2 1985 1985 CD cord-353298-vr5hnzp8 75 3 ) ) -RRB- cord-353298-vr5hnzp8 75 4 . . . cord-353298-vr5hnzp8 76 1 The the DT cord-353298-vr5hnzp8 76 2 tissue tissue NN cord-353298-vr5hnzp8 76 3 was be VBD cord-353298-vr5hnzp8 76 4 incubated incubate VBN cord-353298-vr5hnzp8 76 5 at at IN cord-353298-vr5hnzp8 76 6 37 37 CD cord-353298-vr5hnzp8 76 7 ° ° NN cord-353298-vr5hnzp8 76 8 C c NN cord-353298-vr5hnzp8 76 9 with with IN cord-353298-vr5hnzp8 76 10 enzymes enzyme NNS cord-353298-vr5hnzp8 76 11 ( ( -LRB- cord-353298-vr5hnzp8 76 12 twice twice RB cord-353298-vr5hnzp8 76 13 for for IN cord-353298-vr5hnzp8 76 14 20 20 CD cord-353298-vr5hnzp8 76 15 rain rain NN cord-353298-vr5hnzp8 76 16 in in IN cord-353298-vr5hnzp8 76 17 0.125 0.125 CD cord-353298-vr5hnzp8 76 18 % % NN cord-353298-vr5hnzp8 76 19 trypsin trypsin NN cord-353298-vr5hnzp8 76 20 with with IN cord-353298-vr5hnzp8 76 21 0.02 0.02 CD cord-353298-vr5hnzp8 76 22 % % NN cord-353298-vr5hnzp8 76 23 collagenase collagenase NN cord-353298-vr5hnzp8 76 24 in in IN cord-353298-vr5hnzp8 76 25 MEM MEM NNP cord-353298-vr5hnzp8 76 26 - - HYPH cord-353298-vr5hnzp8 76 27 Hepes Hepes NNP cord-353298-vr5hnzp8 76 28 followed follow VBD cord-353298-vr5hnzp8 76 29 by by IN cord-353298-vr5hnzp8 76 30 one one CD cord-353298-vr5hnzp8 76 31 15-min 15-min CD cord-353298-vr5hnzp8 76 32 incubation incubation NN cord-353298-vr5hnzp8 76 33 in in IN cord-353298-vr5hnzp8 76 34 0.05 0.05 CD cord-353298-vr5hnzp8 76 35 % % NN cord-353298-vr5hnzp8 76 36 trypsin trypsin NN cord-353298-vr5hnzp8 76 37 with with IN cord-353298-vr5hnzp8 76 38 0.53 0.53 CD cord-353298-vr5hnzp8 76 39 M M NNP cord-353298-vr5hnzp8 76 40 EDTA EDTA NNP cord-353298-vr5hnzp8 76 41 ) ) -RRB- cord-353298-vr5hnzp8 76 42 , , , cord-353298-vr5hnzp8 76 43 bathed bathe VBN cord-353298-vr5hnzp8 76 44 in in IN cord-353298-vr5hnzp8 76 45 a a DT cord-353298-vr5hnzp8 76 46 solution solution NN cord-353298-vr5hnzp8 76 47 that that WDT cord-353298-vr5hnzp8 76 48 inhibited inhibit VBD cord-353298-vr5hnzp8 76 49 trypsin trypsin NN cord-353298-vr5hnzp8 76 50 and and CC cord-353298-vr5hnzp8 76 51 digested digest VBD cord-353298-vr5hnzp8 76 52 free free JJ cord-353298-vr5hnzp8 76 53 DNA dna NN cord-353298-vr5hnzp8 76 54 ( ( -LRB- cord-353298-vr5hnzp8 76 55 0.25 0.25 CD cord-353298-vr5hnzp8 76 56 % % NN cord-353298-vr5hnzp8 76 57 soybean soybean NN cord-353298-vr5hnzp8 76 58 trypsin trypsin NN cord-353298-vr5hnzp8 76 59 inhibitor inhibitor NN cord-353298-vr5hnzp8 76 60 , , , cord-353298-vr5hnzp8 76 61 0.002 0.002 CD cord-353298-vr5hnzp8 76 62 % % NN cord-353298-vr5hnzp8 77 1 DNase DNase NNP cord-353298-vr5hnzp8 77 2 I i NN cord-353298-vr5hnzp8 77 3 , , , cord-353298-vr5hnzp8 77 4 0.166 0.166 CD cord-353298-vr5hnzp8 77 5 % % NN cord-353298-vr5hnzp8 77 6 BSA BSA NNP cord-353298-vr5hnzp8 77 7 , , , cord-353298-vr5hnzp8 77 8 and and CC cord-353298-vr5hnzp8 77 9 5 5 CD cord-353298-vr5hnzp8 77 10 % % NN cord-353298-vr5hnzp8 77 11 FBS FBS NNP cord-353298-vr5hnzp8 77 12 in in IN cord-353298-vr5hnzp8 77 13 DME DME NNP cord-353298-vr5hnzp8 77 14 ) ) -RRB- cord-353298-vr5hnzp8 77 15 and and CC cord-353298-vr5hnzp8 77 16 passaged passage VBD cord-353298-vr5hnzp8 77 17 through through IN cord-353298-vr5hnzp8 77 18 pipettes pipette NNS cord-353298-vr5hnzp8 77 19 ( ( -LRB- cord-353298-vr5hnzp8 77 20 5 5 CD cord-353298-vr5hnzp8 77 21 ml ml NN cord-353298-vr5hnzp8 77 22 , , , cord-353298-vr5hnzp8 77 23 10 10 CD cord-353298-vr5hnzp8 77 24 times time NNS cord-353298-vr5hnzp8 77 25 ; ; : cord-353298-vr5hnzp8 77 26 1 1 CD cord-353298-vr5hnzp8 77 27 ml ml NNS cord-353298-vr5hnzp8 77 28 , , , cord-353298-vr5hnzp8 77 29 10 10 CD cord-353298-vr5hnzp8 77 30 times time NNS cord-353298-vr5hnzp8 77 31 ; ; : cord-353298-vr5hnzp8 77 32 Pasteur Pasteur NNP cord-353298-vr5hnzp8 77 33 pipette pipette VBP cord-353298-vr5hnzp8 77 34 10 10 CD cord-353298-vr5hnzp8 77 35 times time NNS cord-353298-vr5hnzp8 77 36 ) ) -RRB- cord-353298-vr5hnzp8 77 37 . . . cord-353298-vr5hnzp8 78 1 Floating float VBG cord-353298-vr5hnzp8 78 2 cells cell NNS cord-353298-vr5hnzp8 78 3 were be VBD cord-353298-vr5hnzp8 78 4 transferred transfer VBN cord-353298-vr5hnzp8 78 5 to to IN cord-353298-vr5hnzp8 78 6 a a DT cord-353298-vr5hnzp8 78 7 50-ml 50-ml CD cord-353298-vr5hnzp8 78 8 tube tube NN cord-353298-vr5hnzp8 78 9 which which WDT cord-353298-vr5hnzp8 78 10 was be VBD cord-353298-vr5hnzp8 78 11 then then RB cord-353298-vr5hnzp8 78 12 filled fill VBN cord-353298-vr5hnzp8 78 13 with with IN cord-353298-vr5hnzp8 78 14 isolation isolation NN cord-353298-vr5hnzp8 78 15 medium medium NN cord-353298-vr5hnzp8 78 16 ( ( -LRB- cord-353298-vr5hnzp8 78 17 1 1 CD cord-353298-vr5hnzp8 78 18 mM mM NNP cord-353298-vr5hnzp8 78 19 Hepes Hepes NNP cord-353298-vr5hnzp8 78 20 , , , cord-353298-vr5hnzp8 79 1 50 50 CD cord-353298-vr5hnzp8 79 2 U u NN cord-353298-vr5hnzp8 79 3 / / SYM cord-353298-vr5hnzp8 79 4 ml ml NN cord-353298-vr5hnzp8 79 5 penicillin penicillin NN cord-353298-vr5hnzp8 79 6 , , , cord-353298-vr5hnzp8 79 7 50 50 CD cord-353298-vr5hnzp8 79 8 # # NN cord-353298-vr5hnzp8 79 9 g g NN cord-353298-vr5hnzp8 79 10 / / SYM cord-353298-vr5hnzp8 79 11 ml ml NN cord-353298-vr5hnzp8 79 12 strep~ strep~ NN cord-353298-vr5hnzp8 79 13 tomycin tomycin NNS cord-353298-vr5hnzp8 79 14 , , , cord-353298-vr5hnzp8 79 15 and and CC cord-353298-vr5hnzp8 79 16 25 25 CD cord-353298-vr5hnzp8 79 17 / / SYM cord-353298-vr5hnzp8 79 18 zg zg NNP cord-353298-vr5hnzp8 79 19 / / , cord-353298-vr5hnzp8 79 20 ml ml NN cord-353298-vr5hnzp8 79 21 gentamycin gentamycin NNS cord-353298-vr5hnzp8 79 22 in in IN cord-353298-vr5hnzp8 79 23 HBSS HBSS NNP cord-353298-vr5hnzp8 79 24 without without IN cord-353298-vr5hnzp8 79 25 calcium calcium NN cord-353298-vr5hnzp8 79 26 or or CC cord-353298-vr5hnzp8 79 27 magnesium magnesium NN cord-353298-vr5hnzp8 79 28 , , , cord-353298-vr5hnzp8 79 29 pH pH NNP cord-353298-vr5hnzp8 79 30 7.4 7.4 CD cord-353298-vr5hnzp8 79 31 ) ) -RRB- cord-353298-vr5hnzp8 79 32 and and CC cord-353298-vr5hnzp8 79 33 spun spin VBD cord-353298-vr5hnzp8 79 34 for for IN cord-353298-vr5hnzp8 79 35 10 10 CD cord-353298-vr5hnzp8 79 36 min min NN cord-353298-vr5hnzp8 79 37 at at IN cord-353298-vr5hnzp8 79 38 1,500 1,500 CD cord-353298-vr5hnzp8 79 39 rpm rpm NN cord-353298-vr5hnzp8 79 40 in in IN cord-353298-vr5hnzp8 79 41 a a DT cord-353298-vr5hnzp8 79 42 centrifuge centrifuge NN cord-353298-vr5hnzp8 79 43 ( ( -LRB- cord-353298-vr5hnzp8 79 44 GLC-2B GLC-2B NNP cord-353298-vr5hnzp8 80 1 ; ; : cord-353298-vr5hnzp8 80 2 Sorvall Sorvall NNP cord-353298-vr5hnzp8 80 3 Die die VB cord-353298-vr5hnzp8 80 4 . . . cord-353298-vr5hnzp8 81 1 , , , cord-353298-vr5hnzp8 81 2 Newton Newton NNP cord-353298-vr5hnzp8 81 3 , , , cord-353298-vr5hnzp8 81 4 CT CT NNP cord-353298-vr5hnzp8 81 5 ) ) -RRB- cord-353298-vr5hnzp8 81 6 . . . cord-353298-vr5hnzp8 82 1 The the DT cord-353298-vr5hnzp8 82 2 supernatant supernatant NN cord-353298-vr5hnzp8 82 3 was be VBD cord-353298-vr5hnzp8 82 4 removed remove VBN cord-353298-vr5hnzp8 82 5 and and CC cord-353298-vr5hnzp8 82 6 pelleted pellete VBN cord-353298-vr5hnzp8 82 7 cells cell NNS cord-353298-vr5hnzp8 82 8 were be VBD cord-353298-vr5hnzp8 82 9 resuspended resuspend VBN cord-353298-vr5hnzp8 82 10 in in IN cord-353298-vr5hnzp8 82 11 10 10 CD cord-353298-vr5hnzp8 82 12 ml ml NNS cord-353298-vr5hnzp8 82 13 of of IN cord-353298-vr5hnzp8 82 14 isolation isolation NN cord-353298-vr5hnzp8 82 15 medium medium NN cord-353298-vr5hnzp8 82 16 . . . cord-353298-vr5hnzp8 83 1 Glial glial JJ cord-353298-vr5hnzp8 83 2 cells cell NNS cord-353298-vr5hnzp8 83 3 were be VBD cord-353298-vr5hnzp8 83 4 separated separate VBN cord-353298-vr5hnzp8 83 5 from from IN cord-353298-vr5hnzp8 83 6 myelin myelin NN cord-353298-vr5hnzp8 83 7 and and CC cord-353298-vr5hnzp8 83 8 red red JJ cord-353298-vr5hnzp8 83 9 blood blood NN cord-353298-vr5hnzp8 83 10 cells cell NNS cord-353298-vr5hnzp8 83 11 using use VBG cord-353298-vr5hnzp8 83 12 a a DT cord-353298-vr5hnzp8 83 13 30 30 CD cord-353298-vr5hnzp8 83 14 % % NN cord-353298-vr5hnzp8 83 15 Percoll Percoll NNP cord-353298-vr5hnzp8 83 16 gradient gradient NN cord-353298-vr5hnzp8 83 17 ( ( -LRB- cord-353298-vr5hnzp8 83 18 Hirayama Hirayama NNP cord-353298-vr5hnzp8 83 19 et et FW cord-353298-vr5hnzp8 83 20 al al NNP cord-353298-vr5hnzp8 83 21 . . NNP cord-353298-vr5hnzp8 83 22 , , , cord-353298-vr5hnzp8 83 23 1983 1983 CD cord-353298-vr5hnzp8 83 24 ; ; : cord-353298-vr5hnzp8 83 25 Kim Kim NNP cord-353298-vr5hnzp8 83 26 et et NNP cord-353298-vr5hnzp8 83 27 al al NNP cord-353298-vr5hnzp8 83 28 . . NNP cord-353298-vr5hnzp8 83 29 , , , cord-353298-vr5hnzp8 83 30 1985 1985 CD cord-353298-vr5hnzp8 83 31 ) ) -RRB- cord-353298-vr5hnzp8 83 32 . . . cord-353298-vr5hnzp8 84 1 The the DT cord-353298-vr5hnzp8 84 2 gradient gradient NN cord-353298-vr5hnzp8 84 3 was be VBD cord-353298-vr5hnzp8 84 4 centrifuged centrifuge VBN cord-353298-vr5hnzp8 84 5 in in IN cord-353298-vr5hnzp8 84 6 an an DT cord-353298-vr5hnzp8 84 7 ultracentrifuge ultracentrifuge JJ cord-353298-vr5hnzp8 84 8 ( ( -LRB- cord-353298-vr5hnzp8 84 9 Beckman Beckman NNP cord-353298-vr5hnzp8 84 10 Instruments Instruments NNP cord-353298-vr5hnzp8 84 11 , , , cord-353298-vr5hnzp8 84 12 Palo Palo NNP cord-353298-vr5hnzp8 84 13 Alto Alto NNP cord-353298-vr5hnzp8 84 14 , , , cord-353298-vr5hnzp8 84 15 CA CA NNP cord-353298-vr5hnzp8 84 16 ) ) -RRB- cord-353298-vr5hnzp8 84 17 equipped equip VBN cord-353298-vr5hnzp8 84 18 with with IN cord-353298-vr5hnzp8 84 19 a a DT cord-353298-vr5hnzp8 84 20 JA20 JA20 NNP cord-353298-vr5hnzp8 84 21 fixed fix VBN cord-353298-vr5hnzp8 84 22 - - HYPH cord-353298-vr5hnzp8 84 23 angle angle NN cord-353298-vr5hnzp8 84 24 rotor rotor NN cord-353298-vr5hnzp8 84 25 spun spin VBD cord-353298-vr5hnzp8 84 26 at at IN cord-353298-vr5hnzp8 84 27 14,000 14,000 CD cord-353298-vr5hnzp8 84 28 rpm rpm NN cord-353298-vr5hnzp8 84 29 for for IN cord-353298-vr5hnzp8 84 30 45 45 CD cord-353298-vr5hnzp8 84 31 min min NN cord-353298-vr5hnzp8 84 32 at at IN cord-353298-vr5hnzp8 84 33 4 4 CD cord-353298-vr5hnzp8 84 34 ° ° NN cord-353298-vr5hnzp8 84 35 C c NN cord-353298-vr5hnzp8 84 36 . . . cord-353298-vr5hnzp8 85 1 The the DT cord-353298-vr5hnzp8 85 2 glial glial JJ cord-353298-vr5hnzp8 85 3 cell cell NN cord-353298-vr5hnzp8 85 4 layer layer NN cord-353298-vr5hnzp8 85 5 , , , cord-353298-vr5hnzp8 85 6 the the DT cord-353298-vr5hnzp8 85 7 region region NN cord-353298-vr5hnzp8 85 8 below below IN cord-353298-vr5hnzp8 85 9 the the DT cord-353298-vr5hnzp8 85 10 myelin myelin NN cord-353298-vr5hnzp8 85 11 cap cap NN cord-353298-vr5hnzp8 85 12 and and CC cord-353298-vr5hnzp8 85 13 above above IN cord-353298-vr5hnzp8 85 14 the the DT cord-353298-vr5hnzp8 85 15 red red JJ cord-353298-vr5hnzp8 85 16 blood blood NN cord-353298-vr5hnzp8 85 17 cells cell NNS cord-353298-vr5hnzp8 85 18 , , , cord-353298-vr5hnzp8 85 19 was be VBD cord-353298-vr5hnzp8 85 20 transferred transfer VBN cord-353298-vr5hnzp8 85 21 to to IN cord-353298-vr5hnzp8 85 22 a a DT cord-353298-vr5hnzp8 85 23 50-ml 50-ml CD cord-353298-vr5hnzp8 85 24 tube tube NN cord-353298-vr5hnzp8 85 25 that that WDT cord-353298-vr5hnzp8 85 26 was be VBD cord-353298-vr5hnzp8 85 27 then then RB cord-353298-vr5hnzp8 85 28 filled fill VBN cord-353298-vr5hnzp8 85 29 with with IN cord-353298-vr5hnzp8 85 30 isolation isolation NN cord-353298-vr5hnzp8 85 31 medium medium NN cord-353298-vr5hnzp8 85 32 and and CC cord-353298-vr5hnzp8 85 33 spun spin VBD cord-353298-vr5hnzp8 85 34 for for IN cord-353298-vr5hnzp8 85 35 10 10 CD cord-353298-vr5hnzp8 85 36 minutes minute NNS cord-353298-vr5hnzp8 85 37 at at IN cord-353298-vr5hnzp8 85 38 1,500 1,500 CD cord-353298-vr5hnzp8 85 39 rpm rpm NN cord-353298-vr5hnzp8 85 40 in in IN cord-353298-vr5hnzp8 85 41 a a DT cord-353298-vr5hnzp8 85 42 centrifuge centrifuge NN cord-353298-vr5hnzp8 85 43 ( ( -LRB- cord-353298-vr5hnzp8 85 44 GLC-2B GLC-2B NNP cord-353298-vr5hnzp8 85 45 ; ; : cord-353298-vr5hnzp8 85 46 Sorvall Sorvall NNP cord-353298-vr5hnzp8 85 47 Div Div NNP cord-353298-vr5hnzp8 85 48 . . . cord-353298-vr5hnzp8 85 49 ) ) -RRB- cord-353298-vr5hnzp8 85 50 . . . cord-353298-vr5hnzp8 86 1 The the DT cord-353298-vr5hnzp8 86 2 supernatant supernatant NN cord-353298-vr5hnzp8 86 3 was be VBD cord-353298-vr5hnzp8 86 4 removed remove VBN cord-353298-vr5hnzp8 86 5 and and CC cord-353298-vr5hnzp8 86 6 the the DT cord-353298-vr5hnzp8 86 7 pelleted pelleted JJ cord-353298-vr5hnzp8 86 8 cells cell NNS cord-353298-vr5hnzp8 86 9 were be VBD cord-353298-vr5hnzp8 86 10 resuspended resuspend VBN cord-353298-vr5hnzp8 86 11 ( ( -LRB- cord-353298-vr5hnzp8 86 12 800 800 CD cord-353298-vr5hnzp8 86 13 pl pl NN cord-353298-vr5hnzp8 86 14 / / SYM cord-353298-vr5hnzp8 86 15 spinal spinal JJ cord-353298-vr5hnzp8 86 16 cord cord NN cord-353298-vr5hnzp8 86 17 ) ) -RRB- cord-353298-vr5hnzp8 86 18 in in IN cord-353298-vr5hnzp8 86 19 10 10 CD cord-353298-vr5hnzp8 86 20 % % NN cord-353298-vr5hnzp8 86 21 FBS FBS NNP cord-353298-vr5hnzp8 86 22 in in IN cord-353298-vr5hnzp8 86 23 DME DME NNP cord-353298-vr5hnzp8 86 24 with with IN cord-353298-vr5hnzp8 86 25 584 584 CD cord-353298-vr5hnzp8 86 26 mg mg NNP cord-353298-vr5hnzp8 86 27 / / SYM cord-353298-vr5hnzp8 86 28 liter liter NN cord-353298-vr5hnzp8 86 29 L l NN cord-353298-vr5hnzp8 86 30 - - HYPH cord-353298-vr5hnzp8 86 31 glutamine glutamine NN cord-353298-vr5hnzp8 86 32 , , , cord-353298-vr5hnzp8 86 33 4.5 4.5 CD cord-353298-vr5hnzp8 86 34 g g NN cord-353298-vr5hnzp8 86 35 / / SYM cord-353298-vr5hnzp8 86 36 liter liter NN cord-353298-vr5hnzp8 86 37 v v NN cord-353298-vr5hnzp8 86 38 - - HYPH cord-353298-vr5hnzp8 86 39 glucose glucose NN cord-353298-vr5hnzp8 86 40 , , , cord-353298-vr5hnzp8 86 41 25 25 CD cord-353298-vr5hnzp8 86 42 # # NN cord-353298-vr5hnzp8 86 43 g g NN cord-353298-vr5hnzp8 86 44 / / SYM cord-353298-vr5hnzp8 86 45 ml ml NN cord-353298-vr5hnzp8 86 46 gentamycin gentamycin NNS cord-353298-vr5hnzp8 86 47 , , , cord-353298-vr5hnzp8 86 48 and and CC cord-353298-vr5hnzp8 86 49 1 1 CD cord-353298-vr5hnzp8 86 50 mM mm CD cord-353298-vr5hnzp8 86 51 sodium sodium NN cord-353298-vr5hnzp8 86 52 pyruvate pyruvate NN cord-353298-vr5hnzp8 86 53 . . . cord-353298-vr5hnzp8 87 1 In in IN cord-353298-vr5hnzp8 87 2 all all DT cord-353298-vr5hnzp8 87 3 cases case NNS cord-353298-vr5hnzp8 87 4 , , , cord-353298-vr5hnzp8 87 5 200 200 CD cord-353298-vr5hnzp8 87 6 ~tl ~tl JJ cord-353298-vr5hnzp8 87 7 of of IN cord-353298-vr5hnzp8 87 8 cell cell NN cord-353298-vr5hnzp8 87 9 suspension suspension NN cord-353298-vr5hnzp8 87 10 was be VBD cord-353298-vr5hnzp8 87 11 plated plate VBN cord-353298-vr5hnzp8 87 12 per per IN cord-353298-vr5hnzp8 87 13 35-mm 35-mm CD cord-353298-vr5hnzp8 87 14 plastic plastic NN cord-353298-vr5hnzp8 87 15 dish dish NN cord-353298-vr5hnzp8 87 16 ( ( -LRB- cord-353298-vr5hnzp8 87 17 coated coat VBN cord-353298-vr5hnzp8 87 18 with with IN cord-353298-vr5hnzp8 87 19 extracellular extracellular JJ cord-353298-vr5hnzp8 87 20 matrix matrix NN cord-353298-vr5hnzp8 87 21 ; ; : cord-353298-vr5hnzp8 87 22 Accurate Accurate NNP cord-353298-vr5hnzp8 87 23 Chemical Chemical NNP cord-353298-vr5hnzp8 87 24 & & CC cord-353298-vr5hnzp8 87 25 Scientific Scientific NNP cord-353298-vr5hnzp8 87 26 Corp. Corp. NNP cord-353298-vr5hnzp8 87 27 , , , cord-353298-vr5hnzp8 87 28 Westbury Westbury NNP cord-353298-vr5hnzp8 87 29 , , , cord-353298-vr5hnzp8 87 30 NY NY NNP cord-353298-vr5hnzp8 87 31 ) ) -RRB- cord-353298-vr5hnzp8 87 32 . . . cord-353298-vr5hnzp8 88 1 After after IN cord-353298-vr5hnzp8 88 2 incubating incubate VBG cord-353298-vr5hnzp8 88 3 for for IN cord-353298-vr5hnzp8 88 4 1 1 CD cord-353298-vr5hnzp8 88 5 h h NN cord-353298-vr5hnzp8 88 6 at at IN cord-353298-vr5hnzp8 88 7 37 37 CD cord-353298-vr5hnzp8 88 8 ° ° NN cord-353298-vr5hnzp8 88 9 C c NN cord-353298-vr5hnzp8 88 10 to to TO cord-353298-vr5hnzp8 88 11 enhance enhance VB cord-353298-vr5hnzp8 88 12 attachment attachment NN cord-353298-vr5hnzp8 88 13 , , , cord-353298-vr5hnzp8 88 14 the the DT cord-353298-vr5hnzp8 88 15 cultures culture NNS cord-353298-vr5hnzp8 88 16 were be VBD cord-353298-vr5hnzp8 88 17 fed feed VBN cord-353298-vr5hnzp8 88 18 with with IN cord-353298-vr5hnzp8 88 19 2 2 CD cord-353298-vr5hnzp8 88 20 ml ml NNS cord-353298-vr5hnzp8 88 21 of of IN cord-353298-vr5hnzp8 88 22 10 10 CD cord-353298-vr5hnzp8 88 23 % % NN cord-353298-vr5hnzp8 88 24 FBS FBS NNP cord-353298-vr5hnzp8 88 25 - - HYPH cord-353298-vr5hnzp8 88 26 DME DME NNP cord-353298-vr5hnzp8 88 27 solution solution NN cord-353298-vr5hnzp8 88 28 . . . cord-353298-vr5hnzp8 89 1 At at IN cord-353298-vr5hnzp8 89 2 1 1 CD cord-353298-vr5hnzp8 89 3 and and CC cord-353298-vr5hnzp8 89 4 3 3 CD cord-353298-vr5hnzp8 89 5 d d NN cord-353298-vr5hnzp8 89 6 in in FW cord-353298-vr5hnzp8 89 7 vitro vitro FW cord-353298-vr5hnzp8 89 8 ( ( -LRB- cord-353298-vr5hnzp8 89 9 die die VB cord-353298-vr5hnzp8 89 10 ) ) -RRB- cord-353298-vr5hnzp8 89 11 cultures culture NNS cord-353298-vr5hnzp8 89 12 were be VBD cord-353298-vr5hnzp8 89 13 fed feed VBN cord-353298-vr5hnzp8 89 14 with with IN cord-353298-vr5hnzp8 89 15 0.5 0.5 CD cord-353298-vr5hnzp8 89 16 % % NN cord-353298-vr5hnzp8 89 17 FBS FBS NNP cord-353298-vr5hnzp8 89 18 in in IN cord-353298-vr5hnzp8 89 19 defined define VBN cord-353298-vr5hnzp8 89 20 medium medium NN cord-353298-vr5hnzp8 89 21 ( ( -LRB- cord-353298-vr5hnzp8 89 22 DME DME NNP cord-353298-vr5hnzp8 89 23 with with IN cord-353298-vr5hnzp8 89 24 584 584 CD cord-353298-vr5hnzp8 89 25 mg mg NNP cord-353298-vr5hnzp8 89 26 / / SYM cord-353298-vr5hnzp8 89 27 liter liter NN cord-353298-vr5hnzp8 89 28 L l NN cord-353298-vr5hnzp8 89 29 - - HYPH cord-353298-vr5hnzp8 89 30 glutamine glutamine NN cord-353298-vr5hnzp8 89 31 , , , cord-353298-vr5hnzp8 89 32 4.5 4.5 CD cord-353298-vr5hnzp8 89 33 g g NN cord-353298-vr5hnzp8 89 34 / / SYM cord-353298-vr5hnzp8 89 35 liter liter NN cord-353298-vr5hnzp8 89 36 v v NN cord-353298-vr5hnzp8 89 37 - - HYPH cord-353298-vr5hnzp8 89 38 glucose glucose NN cord-353298-vr5hnzp8 89 39 , , , cord-353298-vr5hnzp8 89 40 5/~g 5/~g CD cord-353298-vr5hnzp8 89 41 / / SYM cord-353298-vr5hnzp8 89 42 ml ml NN cord-353298-vr5hnzp8 89 43 insulin insulin NN cord-353298-vr5hnzp8 89 44 , , , cord-353298-vr5hnzp8 90 1 50 50 CD cord-353298-vr5hnzp8 90 2 /~g /~g , cord-353298-vr5hnzp8 90 3 / / SYM cord-353298-vr5hnzp8 90 4 ml ml NN cord-353298-vr5hnzp8 90 5 transferrin transferrin NN cord-353298-vr5hnzp8 90 6 , , , cord-353298-vr5hnzp8 90 7 30 30 CD cord-353298-vr5hnzp8 90 8 nM nm CD cord-353298-vr5hnzp8 90 9 selenium selenium NN cord-353298-vr5hnzp8 90 10 , , , cord-353298-vr5hnzp8 90 11 30 30 CD cord-353298-vr5hnzp8 90 12 nM nm NN cord-353298-vr5hnzp8 90 13 triiodothyronine triiodothyronine NNP cord-353298-vr5hnzp8 90 14 , , , cord-353298-vr5hnzp8 90 15 25 25 CD cord-353298-vr5hnzp8 90 16 # # $ cord-353298-vr5hnzp8 90 17 g g NN cord-353298-vr5hnzp8 90 18 / / SYM cord-353298-vr5hnzp8 90 19 ml ml NN cord-353298-vr5hnzp8 90 20 gentamycin gentamycin NNS cord-353298-vr5hnzp8 90 21 , , , cord-353298-vr5hnzp8 90 22 and and CC cord-353298-vr5hnzp8 90 23 1 1 CD cord-353298-vr5hnzp8 90 24 mM mm CD cord-353298-vr5hnzp8 90 25 sodium sodium NN cord-353298-vr5hnzp8 90 26 pyruvate pyruvate NN cord-353298-vr5hnzp8 90 27 ; ; , cord-353298-vr5hnzp8 90 28 modified modify VBN cord-353298-vr5hnzp8 90 29 from from IN cord-353298-vr5hnzp8 90 30 Eccleston Eccleston NNP cord-353298-vr5hnzp8 90 31 and and CC cord-353298-vr5hnzp8 90 32 Silberberg Silberberg NNP cord-353298-vr5hnzp8 90 33 , , , cord-353298-vr5hnzp8 90 34 1984 1984 CD cord-353298-vr5hnzp8 90 35 ) ) -RRB- cord-353298-vr5hnzp8 90 36 . . . cord-353298-vr5hnzp8 91 1 The the DT cord-353298-vr5hnzp8 91 2 cultures culture NNS cord-353298-vr5hnzp8 91 3 were be VBD cord-353298-vr5hnzp8 91 4 grown grow VBN cord-353298-vr5hnzp8 91 5 in in IN cord-353298-vr5hnzp8 91 6 this this DT cord-353298-vr5hnzp8 91 7 low low JJ cord-353298-vr5hnzp8 91 8 serum serum NN cord-353298-vr5hnzp8 91 9 defined define VBN cord-353298-vr5hnzp8 91 10 medium medium NN cord-353298-vr5hnzp8 91 11 to to TO cord-353298-vr5hnzp8 91 12 enhance enhance VB cord-353298-vr5hnzp8 91 13 the the DT cord-353298-vr5hnzp8 91 14 growth growth NN cord-353298-vr5hnzp8 91 15 of of IN cord-353298-vr5hnzp8 91 16 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 91 17 relative relative JJ cord-353298-vr5hnzp8 91 18 to to IN cord-353298-vr5hnzp8 91 19 fibroblasts fibroblast NNS cord-353298-vr5hnzp8 91 20 . . . cord-353298-vr5hnzp8 92 1 After after IN cord-353298-vr5hnzp8 92 2 l l NNP cord-353298-vr5hnzp8 92 3 , , , cord-353298-vr5hnzp8 92 4 3 3 CD cord-353298-vr5hnzp8 92 5 , , , cord-353298-vr5hnzp8 92 6 or or CC cord-353298-vr5hnzp8 92 7 6 6 CD cord-353298-vr5hnzp8 92 8 die die NN cord-353298-vr5hnzp8 92 9 , , , cord-353298-vr5hnzp8 92 10 cultures culture NNS cord-353298-vr5hnzp8 92 11 were be VBD cord-353298-vr5hnzp8 92 12 fixed fix VBN cord-353298-vr5hnzp8 92 13 with with IN cord-353298-vr5hnzp8 92 14 2 2 CD cord-353298-vr5hnzp8 92 15 % % NN cord-353298-vr5hnzp8 92 16 paraformaldehyde paraformaldehyde NN cord-353298-vr5hnzp8 92 17 in in IN cord-353298-vr5hnzp8 92 18 MEM MEM NNP cord-353298-vr5hnzp8 92 19 - - HYPH cord-353298-vr5hnzp8 92 20 Hepes Hepes NNP cord-353298-vr5hnzp8 92 21 for for IN cord-353298-vr5hnzp8 92 22 15 15 CD cord-353298-vr5hnzp8 92 23 min min NN cord-353298-vr5hnzp8 92 24 . . . cord-353298-vr5hnzp8 93 1 In in IN cord-353298-vr5hnzp8 93 2 some some DT cord-353298-vr5hnzp8 93 3 experiments experiment NNS cord-353298-vr5hnzp8 93 4 a a DT cord-353298-vr5hnzp8 93 5 terminal terminal JJ cord-353298-vr5hnzp8 93 6 pulse pulse NN cord-353298-vr5hnzp8 93 7 of of IN cord-353298-vr5hnzp8 93 8 [ [ -LRB- cord-353298-vr5hnzp8 93 9 methyl-3H]thymi methyl-3h]thymi NN cord-353298-vr5hnzp8 93 10 ~ ~ NFP cord-353298-vr5hnzp8 93 11 me -PRON- PRP cord-353298-vr5hnzp8 93 12 ( ( -LRB- cord-353298-vr5hnzp8 93 13 67 67 CD cord-353298-vr5hnzp8 93 14 Ci/ Ci/ NNP cord-353298-vr5hnzp8 93 15 mmol mmol NN cord-353298-vr5hnzp8 93 16 ; ; : cord-353298-vr5hnzp8 93 17 New New NNP cord-353298-vr5hnzp8 93 18 England England NNP cord-353298-vr5hnzp8 93 19 Nuclear Nuclear NNP cord-353298-vr5hnzp8 93 20 , , , cord-353298-vr5hnzp8 93 21 Boston Boston NNP cord-353298-vr5hnzp8 93 22 , , , cord-353298-vr5hnzp8 93 23 MA MA NNP cord-353298-vr5hnzp8 93 24 ) ) -RRB- cord-353298-vr5hnzp8 93 25 was be VBD cord-353298-vr5hnzp8 93 26 administered administer VBN cord-353298-vr5hnzp8 93 27 . . . cord-353298-vr5hnzp8 94 1 For for IN cord-353298-vr5hnzp8 94 2 in in IN cord-353298-vr5hnzp8 94 3 vivo vivo NN cord-353298-vr5hnzp8 94 4 labeling labeling NN cord-353298-vr5hnzp8 94 5 , , , cord-353298-vr5hnzp8 94 6 mice mouse NNS cord-353298-vr5hnzp8 94 7 were be VBD cord-353298-vr5hnzp8 94 8 injected inject VBN cord-353298-vr5hnzp8 94 9 intraperitoneally intraperitoneally RB cord-353298-vr5hnzp8 94 10 with with IN cord-353298-vr5hnzp8 94 11 [ [ -LRB- cord-353298-vr5hnzp8 94 12 3I 3i JJ cord-353298-vr5hnzp8 94 13 - - HYPH cord-353298-vr5hnzp8 94 14 l]thymidine l]thymidine NNP cord-353298-vr5hnzp8 94 15 ( ( -LRB- cord-353298-vr5hnzp8 94 16 10 10 CD cord-353298-vr5hnzp8 94 17 # # $ cord-353298-vr5hnzp8 94 18 Ci ci NN cord-353298-vr5hnzp8 94 19 / / SYM cord-353298-vr5hnzp8 94 20 g g NN cord-353298-vr5hnzp8 94 21 body body NN cord-353298-vr5hnzp8 94 22 weight weight NN cord-353298-vr5hnzp8 94 23 ) ) -RRB- cord-353298-vr5hnzp8 95 1 2 2 LS cord-353298-vr5hnzp8 95 2 h h NN cord-353298-vr5hnzp8 95 3 before before IN cord-353298-vr5hnzp8 95 4 death death NN cord-353298-vr5hnzp8 95 5 ( ( -LRB- cord-353298-vr5hnzp8 95 6 see see VB cord-353298-vr5hnzp8 95 7 Fig Fig NNP cord-353298-vr5hnzp8 95 8 . . . cord-353298-vr5hnzp8 95 9 1 1 CD cord-353298-vr5hnzp8 95 10 A a CD cord-353298-vr5hnzp8 95 11 ) ) -RRB- cord-353298-vr5hnzp8 95 12 . . . cord-353298-vr5hnzp8 96 1 For for IN cord-353298-vr5hnzp8 96 2 in in FW cord-353298-vr5hnzp8 96 3 vitro vitro FW cord-353298-vr5hnzp8 96 4 labeling labeling NN cord-353298-vr5hnzp8 96 5 , , , cord-353298-vr5hnzp8 96 6 [ [ -LRB- cord-353298-vr5hnzp8 96 7 3H]thymidine 3h]thymidine CD cord-353298-vr5hnzp8 96 8 ( ( -LRB- cord-353298-vr5hnzp8 96 9 0.05 0.05 CD cord-353298-vr5hnzp8 96 10 # # NN cord-353298-vr5hnzp8 96 11 Ci ci NN cord-353298-vr5hnzp8 96 12 / / SYM cord-353298-vr5hnzp8 96 13 ml ml NN cord-353298-vr5hnzp8 96 14 culture culture NN cord-353298-vr5hnzp8 96 15 media medium NNS cord-353298-vr5hnzp8 96 16 ) ) -RRB- cord-353298-vr5hnzp8 96 17 was be VBD cord-353298-vr5hnzp8 96 18 added add VBN cord-353298-vr5hnzp8 96 19 to to IN cord-353298-vr5hnzp8 96 20 cultures culture NNS cord-353298-vr5hnzp8 96 21 20 20 CD cord-353298-vr5hnzp8 96 22 h h NN cord-353298-vr5hnzp8 96 23 before before IN cord-353298-vr5hnzp8 96 24 fixation fixation NN cord-353298-vr5hnzp8 96 25 ( ( -LRB- cord-353298-vr5hnzp8 96 26 see see VB cord-353298-vr5hnzp8 96 27 Fig Fig NNP cord-353298-vr5hnzp8 96 28 . . . cord-353298-vr5hnzp8 96 29 1 1 CD cord-353298-vr5hnzp8 96 30 B b NN cord-353298-vr5hnzp8 96 31 ) ) -RRB- cord-353298-vr5hnzp8 96 32 . . . cord-353298-vr5hnzp8 97 1 The the DT cord-353298-vr5hnzp8 97 2 growth growth NN cord-353298-vr5hnzp8 97 3 factors factor NNS cord-353298-vr5hnzp8 97 4 tested test VBN cord-353298-vr5hnzp8 97 5 were be VBD cord-353298-vr5hnzp8 97 6 bovine bovine JJ cord-353298-vr5hnzp8 97 7 bFGF bfgf NN cord-353298-vr5hnzp8 97 8 ( ( -LRB- cord-353298-vr5hnzp8 97 9 10 10 CD cord-353298-vr5hnzp8 97 10 ng ng NNP cord-353298-vr5hnzp8 97 11 / / SYM cord-353298-vr5hnzp8 97 12 mi mi NNP cord-353298-vr5hnzp8 97 13 ; ; : cord-353298-vr5hnzp8 97 14 R R NNP cord-353298-vr5hnzp8 97 15 & & CC cord-353298-vr5hnzp8 97 16 D D NNP cord-353298-vr5hnzp8 97 17 Systems Systems NNP cord-353298-vr5hnzp8 97 18 , , , cord-353298-vr5hnzp8 97 19 Minneapolis Minneapolis NNP cord-353298-vr5hnzp8 97 20 , , , cord-353298-vr5hnzp8 97 21 MN MN NNP cord-353298-vr5hnzp8 97 22 ) ) -RRB- cord-353298-vr5hnzp8 97 23 , , , cord-353298-vr5hnzp8 97 24 human human JJ cord-353298-vr5hnzp8 97 25 PDGF PDGF NNP cord-353298-vr5hnzp8 97 26 ( ( -LRB- cord-353298-vr5hnzp8 97 27 10 10 CD cord-353298-vr5hnzp8 97 28 ng ng NNP cord-353298-vr5hnzp8 97 29 / / SYM cord-353298-vr5hnzp8 97 30 mi mi NNP cord-353298-vr5hnzp8 97 31 ; ; : cord-353298-vr5hnzp8 97 32 A a NN cord-353298-vr5hnzp8 97 33 and and CC cord-353298-vr5hnzp8 97 34 B B NNP cord-353298-vr5hnzp8 97 35 chain chain NN cord-353298-vr5hnzp8 97 36 heterodimer heterodimer NN cord-353298-vr5hnzp8 97 37 from from IN cord-353298-vr5hnzp8 97 38 R R NNP cord-353298-vr5hnzp8 97 39 & & CC cord-353298-vr5hnzp8 97 40 D D NNP cord-353298-vr5hnzp8 97 41 Systems Systems NNPS cord-353298-vr5hnzp8 97 42 ) ) -RRB- cord-353298-vr5hnzp8 97 43 , , , cord-353298-vr5hnzp8 97 44 and and CC cord-353298-vr5hnzp8 97 45 human human JJ cord-353298-vr5hnzp8 97 46 insulin insulin NN cord-353298-vr5hnzp8 97 47 - - HYPH cord-353298-vr5hnzp8 97 48 like like JJ cord-353298-vr5hnzp8 97 49 growth growth NN cord-353298-vr5hnzp8 97 50 factor factor NN cord-353298-vr5hnzp8 98 1 I -PRON- PRP cord-353298-vr5hnzp8 98 2 ( ( -LRB- cord-353298-vr5hnzp8 98 3 IGF IGF NNP cord-353298-vr5hnzp8 98 4 - - HYPH cord-353298-vr5hnzp8 98 5 I I NNP cord-353298-vr5hnzp8 98 6 ; ; : cord-353298-vr5hnzp8 98 7 100 100 CD cord-353298-vr5hnzp8 98 8 ng ng NNP cord-353298-vr5hnzp8 98 9 / / SYM cord-353298-vr5hnzp8 98 10 mi mi NNP cord-353298-vr5hnzp8 98 11 ; ; : cord-353298-vr5hnzp8 98 12 Amgen Amgen NNP cord-353298-vr5hnzp8 98 13 Biologicals Biologicals NNP cord-353298-vr5hnzp8 98 14 , , , cord-353298-vr5hnzp8 98 15 Thousand Thousand NNP cord-353298-vr5hnzp8 98 16 Oaks Oaks NNPS cord-353298-vr5hnzp8 98 17 , , , cord-353298-vr5hnzp8 98 18 CA CA NNP cord-353298-vr5hnzp8 98 19 ) ) -RRB- cord-353298-vr5hnzp8 98 20 . . . cord-353298-vr5hnzp8 99 1 Each each DT cord-353298-vr5hnzp8 99 2 growth growth NN cord-353298-vr5hnzp8 99 3 factor factor NN cord-353298-vr5hnzp8 99 4 was be VBD cord-353298-vr5hnzp8 99 5 added add VBN cord-353298-vr5hnzp8 99 6 individually individually RB cord-353298-vr5hnzp8 99 7 to to IN cord-353298-vr5hnzp8 99 8 a a DT cord-353298-vr5hnzp8 99 9 culture culture NN cord-353298-vr5hnzp8 99 10 dish dish NN cord-353298-vr5hnzp8 99 11 at at IN cord-353298-vr5hnzp8 99 12 1 1 CD cord-353298-vr5hnzp8 99 13 div div NN cord-353298-vr5hnzp8 99 14 with with IN cord-353298-vr5hnzp8 99 15 0.5 0.5 CD cord-353298-vr5hnzp8 99 16 % % NN cord-353298-vr5hnzp8 99 17 FBS FBS NNP cord-353298-vr5hnzp8 99 18 in in IN cord-353298-vr5hnzp8 99 19 defined define VBN cord-353298-vr5hnzp8 99 20 medium medium NN cord-353298-vr5hnzp8 99 21 ( ( -LRB- cord-353298-vr5hnzp8 99 22 see see VB cord-353298-vr5hnzp8 99 23 above above RB cord-353298-vr5hnzp8 99 24 ) ) -RRB- cord-353298-vr5hnzp8 99 25 . . . cord-353298-vr5hnzp8 100 1 Cultures culture NNS cord-353298-vr5hnzp8 100 2 were be VBD cord-353298-vr5hnzp8 100 3 subsequently subsequently RB cord-353298-vr5hnzp8 100 4 given give VBN cord-353298-vr5hnzp8 100 5 a a DT cord-353298-vr5hnzp8 100 6 20-h 20-h CD cord-353298-vr5hnzp8 100 7 terminal terminal NN cord-353298-vr5hnzp8 100 8 pulse pulse NN cord-353298-vr5hnzp8 100 9 of of IN cord-353298-vr5hnzp8 100 10 [ [ -LRB- cord-353298-vr5hnzp8 100 11 3I 3i NN cord-353298-vr5hnzp8 100 12 - - HYPH cord-353298-vr5hnzp8 100 13 I]thymidine I]thymidine NNP cord-353298-vr5hnzp8 100 14 and and CC cord-353298-vr5hnzp8 100 15 fixed fix VBN cord-353298-vr5hnzp8 100 16 at at IN cord-353298-vr5hnzp8 100 17 3 3 CD cord-353298-vr5hnzp8 100 18 die die VB cord-353298-vr5hnzp8 100 19 ( ( -LRB- cord-353298-vr5hnzp8 100 20 see see VB cord-353298-vr5hnzp8 100 21 Fig Fig NNP cord-353298-vr5hnzp8 100 22 . . . cord-353298-vr5hnzp8 100 23 1 1 CD cord-353298-vr5hnzp8 100 24 _SP cord-353298-vr5hnzp8 101 1 Immunocytochemistry Immunocytochemistry NNP cord-353298-vr5hnzp8 101 2 O-2A O-2A NNP cord-353298-vr5hnzp8 101 3 lineage lineage NN cord-353298-vr5hnzp8 101 4 cells cell NNS cord-353298-vr5hnzp8 101 5 were be VBD cord-353298-vr5hnzp8 101 6 identified identify VBN cord-353298-vr5hnzp8 101 7 based base VBN cord-353298-vr5hnzp8 101 8 upon upon IN cord-353298-vr5hnzp8 101 9 three three CD cord-353298-vr5hnzp8 101 10 - - HYPH cord-353298-vr5hnzp8 101 11 color color NN cord-353298-vr5hnzp8 101 12 immnnofluorescence immnnofluorescence NN cord-353298-vr5hnzp8 101 13 that that WDT cord-353298-vr5hnzp8 101 14 enabled enable VBD cord-353298-vr5hnzp8 101 15 simultaneous simultaneous JJ cord-353298-vr5hnzp8 101 16 visualization visualization NN cord-353298-vr5hnzp8 101 17 of of IN cord-353298-vr5hnzp8 101 18 reactivity reactivity NN cord-353298-vr5hnzp8 101 19 with with IN cord-353298-vr5hnzp8 101 20 antigalactocerebroside antigalactocerebroside NNP cord-353298-vr5hnzp8 101 21 ( ( -LRB- cord-353298-vr5hnzp8 101 22 GC GC NNP cord-353298-vr5hnzp8 101 23 ) ) -RRB- cord-353298-vr5hnzp8 101 24 , , , cord-353298-vr5hnzp8 101 25 anti anti JJ cord-353298-vr5hnzp8 101 26 - - JJ cord-353298-vr5hnzp8 101 27 glial glial JJ cord-353298-vr5hnzp8 101 28 fibrlllary fibrlllary JJ cord-353298-vr5hnzp8 101 29 acidic acidic JJ cord-353298-vr5hnzp8 101 30 protein protein NN cord-353298-vr5hnzp8 101 31 ( ( -LRB- cord-353298-vr5hnzp8 101 32 GFAP GFAP NNP cord-353298-vr5hnzp8 101 33 ) ) -RRB- cord-353298-vr5hnzp8 101 34 , , , cord-353298-vr5hnzp8 101 35 and and CC cord-353298-vr5hnzp8 101 36 the the DT cord-353298-vr5hnzp8 101 37 04 04 CD cord-353298-vr5hnzp8 101 38 antibody antibody NN cord-353298-vr5hnzp8 101 39 . . . cord-353298-vr5hnzp8 102 1 Anti Anti NNP cord-353298-vr5hnzp8 102 2 - - NNP cord-353298-vr5hnzp8 102 3 GC GC NNP cord-353298-vr5hnzp8 102 4 is be VBZ cord-353298-vr5hnzp8 102 5 a a DT cord-353298-vr5hnzp8 102 6 mouse mouse NN cord-353298-vr5hnzp8 102 7 monoclonal monoclonal JJ cord-353298-vr5hnzp8 102 8 IgG3 igg3 NN cord-353298-vr5hnzp8 102 9 , , , cord-353298-vr5hnzp8 102 10 kindly kindly RB cord-353298-vr5hnzp8 102 11 provided provide VBN cord-353298-vr5hnzp8 102 12 by by IN cord-353298-vr5hnzp8 102 13 B. B. NNP cord-353298-vr5hnzp8 102 14 Ranscht Ranscht NNP cord-353298-vr5hnzp8 102 15 ( ( -LRB- cord-353298-vr5hnzp8 102 16 La La NNP cord-353298-vr5hnzp8 102 17 Jolia Jolia NNP cord-353298-vr5hnzp8 102 18 Cancer Cancer NNP cord-353298-vr5hnzp8 102 19 Research Research NNP cord-353298-vr5hnzp8 102 20 Foundation Foundation NNP cord-353298-vr5hnzp8 102 21 , , , cord-353298-vr5hnzp8 102 22 La La NNP cord-353298-vr5hnzp8 102 23 Jolla Jolla NNP cord-353298-vr5hnzp8 102 24 , , , cord-353298-vr5hnzp8 102 25 CA CA NNP cord-353298-vr5hnzp8 102 26 ) ) -RRB- cord-353298-vr5hnzp8 102 27 , , , cord-353298-vr5hnzp8 102 28 which which WDT cord-353298-vr5hnzp8 102 29 recognizes recognize VBZ cord-353298-vr5hnzp8 102 30 GC GC NNP cord-353298-vr5hnzp8 102 31 and and CC cord-353298-vr5hnzp8 102 32 an an DT cord-353298-vr5hnzp8 102 33 earlier early JJR cord-353298-vr5hnzp8 102 34 antigen antigen NN cord-353298-vr5hnzp8 102 35 emerging emerge VBG cord-353298-vr5hnzp8 102 36 on on IN cord-353298-vr5hnzp8 102 37 the the DT cord-353298-vr5hnzp8 102 38 cell cell NN cord-353298-vr5hnzp8 102 39 surface surface NN cord-353298-vr5hnzp8 102 40 shortly shortly RB cord-353298-vr5hnzp8 102 41 after after IN cord-353298-vr5hnzp8 102 42 the the DT cord-353298-vr5hnzp8 102 43 appearance appearance NN cord-353298-vr5hnzp8 102 44 of of IN cord-353298-vr5hnzp8 102 45 04 04 CD cord-353298-vr5hnzp8 102 46 immunostaining immunostaining NN cord-353298-vr5hnzp8 103 1 ( ( -LRB- cord-353298-vr5hnzp8 103 2 Ranscht Ranscht NNP cord-353298-vr5hnzp8 103 3 et et NNP cord-353298-vr5hnzp8 103 4 al al NNP cord-353298-vr5hnzp8 103 5 . . . cord-353298-vr5hnzp8 104 1 , , , cord-353298-vr5hnzp8 104 2 1982 1982 CD cord-353298-vr5hnzp8 104 3 ; ; : cord-353298-vr5hnzp8 104 4 Bansal Bansal NNP cord-353298-vr5hnzp8 104 5 et et NNP cord-353298-vr5hnzp8 104 6 al al NNP cord-353298-vr5hnzp8 104 7 . . NNP cord-353298-vr5hnzp8 104 8 , , , cord-353298-vr5hnzp8 104 9 1989 1989 CD cord-353298-vr5hnzp8 104 10 ) ) -RRB- cord-353298-vr5hnzp8 104 11 . . . cord-353298-vr5hnzp8 105 1 The the DT cord-353298-vr5hnzp8 105 2 rabbit rabbit NN cord-353298-vr5hnzp8 105 3 polyclonal polyclonal JJ cord-353298-vr5hnzp8 105 4 anti anti NNP cord-353298-vr5hnzp8 105 5 - - NNP cord-353298-vr5hnzp8 105 6 GFAP GFAP NNP cord-353298-vr5hnzp8 105 7 , , , cord-353298-vr5hnzp8 105 8 kindly kindly RB cord-353298-vr5hnzp8 105 9 provided provide VBN cord-353298-vr5hnzp8 105 10 by by IN cord-353298-vr5hnzp8 105 11 R. R. NNP cord-353298-vr5hnzp8 105 12 Pruss Pruss NNP cord-353298-vr5hnzp8 105 13 ( ( -LRB- cord-353298-vr5hnzp8 105 14 Merrill Merrill NNP cord-353298-vr5hnzp8 105 15 Dow Dow NNP cord-353298-vr5hnzp8 105 16 Pharmaceuticals Pharmaceuticals NNPS cord-353298-vr5hnzp8 105 17 , , , cord-353298-vr5hnzp8 105 18 Cincinnati Cincinnati NNP cord-353298-vr5hnzp8 105 19 , , , cord-353298-vr5hnzp8 105 20 OH OH NNP cord-353298-vr5hnzp8 105 21 ) ) -RRB- cord-353298-vr5hnzp8 105 22 , , , cord-353298-vr5hnzp8 105 23 immunostains immunostain VBZ cord-353298-vr5hnzp8 105 24 GFAP GFAP NNP cord-353298-vr5hnzp8 105 25 but but CC cord-353298-vr5hnzp8 105 26 does do VBZ cord-353298-vr5hnzp8 105 27 not not RB cord-353298-vr5hnzp8 105 28 react react VB cord-353298-vr5hnzp8 105 29 with with IN cord-353298-vr5hnzp8 105 30 other other JJ cord-353298-vr5hnzp8 105 31 intermediate intermediate JJ cord-353298-vr5hnzp8 105 32 filament filament NN cord-353298-vr5hnzp8 105 33 proteins protein NNS cord-353298-vr5hnzp8 105 34 . . . cord-353298-vr5hnzp8 106 1 04 04 CD cord-353298-vr5hnzp8 106 2 is be VBZ cord-353298-vr5hnzp8 106 3 a a DT cord-353298-vr5hnzp8 106 4 mouse mouse NN cord-353298-vr5hnzp8 106 5 monoclonal monoclonal JJ cord-353298-vr5hnzp8 106 6 IgM IgM NNP cord-353298-vr5hnzp8 106 7 , , , cord-353298-vr5hnzp8 106 8 kindly kindly RB cord-353298-vr5hnzp8 106 9 provided provide VBN cord-353298-vr5hnzp8 106 10 by by IN cord-353298-vr5hnzp8 106 11 1 1 CD cord-353298-vr5hnzp8 106 12 . . . cord-353298-vr5hnzp8 107 1 Sommer Sommer NNP cord-353298-vr5hnzp8 107 2 ( ( -LRB- cord-353298-vr5hnzp8 107 3 Southern Southern NNP cord-353298-vr5hnzp8 107 4 General General NNP cord-353298-vr5hnzp8 107 5 Hospital Hospital NNP cord-353298-vr5hnzp8 107 6 , , , cord-353298-vr5hnzp8 107 7 Glasgow Glasgow NNP cord-353298-vr5hnzp8 107 8 , , , cord-353298-vr5hnzp8 107 9 Scotland Scotland NNP cord-353298-vr5hnzp8 107 10 ) ) -RRB- cord-353298-vr5hnzp8 107 11 , , , cord-353298-vr5hnzp8 107 12 ( ( -LRB- cord-353298-vr5hnzp8 107 13 Sommer Sommer NNP cord-353298-vr5hnzp8 107 14 and and CC cord-353298-vr5hnzp8 107 15 Schachner Schachner NNP cord-353298-vr5hnzp8 107 16 , , , cord-353298-vr5hnzp8 107 17 1981 1981 CD cord-353298-vr5hnzp8 107 18 ) ) -RRB- cord-353298-vr5hnzp8 107 19 which which WDT cord-353298-vr5hnzp8 107 20 recognizes recognize VBZ cord-353298-vr5hnzp8 107 21 sulfatide sulfatide NNP cord-353298-vr5hnzp8 107 22 , , , cord-353298-vr5hnzp8 107 23 seminolipid seminolipid NNP cord-353298-vr5hnzp8 107 24 , , , cord-353298-vr5hnzp8 107 25 and and CC cord-353298-vr5hnzp8 107 26 an an DT cord-353298-vr5hnzp8 107 27 unidentified unidentified JJ cord-353298-vr5hnzp8 107 28 antigen antigen NN cord-353298-vr5hnzp8 107 29 ( ( -LRB- cord-353298-vr5hnzp8 107 30 Bansal Bansal NNP cord-353298-vr5hnzp8 107 31 et et NNP cord-353298-vr5hnzp8 107 32 al al NNP cord-353298-vr5hnzp8 107 33 . . NNP cord-353298-vr5hnzp8 107 34 , , , cord-353298-vr5hnzp8 107 35 1989 1989 CD cord-353298-vr5hnzp8 107 36 ) ) -RRB- cord-353298-vr5hnzp8 107 37 . . . cord-353298-vr5hnzp8 108 1 04 04 CD cord-353298-vr5hnzp8 108 2 and and CC cord-353298-vr5hnzp8 108 3 anti anti NNP cord-353298-vr5hnzp8 108 4 - - NNP cord-353298-vr5hnzp8 108 5 GC GC NNP cord-353298-vr5hnzp8 108 6 were be VBD cord-353298-vr5hnzp8 108 7 supernatants supernatant NNS cord-353298-vr5hnzp8 108 8 from from IN cord-353298-vr5hnzp8 108 9 hybridoma hybridoma NN cord-353298-vr5hnzp8 108 10 cultures culture NNS cord-353298-vr5hnzp8 108 11 containing contain VBG cord-353298-vr5hnzp8 108 12 10 10 CD cord-353298-vr5hnzp8 108 13 % % NN cord-353298-vr5hnzp8 108 14 FBS FBS NNP cord-353298-vr5hnzp8 108 15 in in IN cord-353298-vr5hnzp8 108 16 DME DME NNP cord-353298-vr5hnzp8 108 17 . . . cord-353298-vr5hnzp8 109 1 The the DT cord-353298-vr5hnzp8 109 2 supernntants supernntant NNS cord-353298-vr5hnzp8 109 3 were be VBD cord-353298-vr5hnzp8 109 4 mixed mix VBN cord-353298-vr5hnzp8 109 5 together together RB cord-353298-vr5hnzp8 109 6 and and CC cord-353298-vr5hnzp8 109 7 diluted dilute VBN cord-353298-vr5hnzp8 109 8 1:4 1:4 CD cord-353298-vr5hnzp8 109 9 and and CC cord-353298-vr5hnzp8 109 10 1:2 1:2 CD cord-353298-vr5hnzp8 109 11 , , , cord-353298-vr5hnzp8 109 12 respectively respectively RB cord-353298-vr5hnzp8 109 13 , , , cord-353298-vr5hnzp8 109 14 in in IN cord-353298-vr5hnzp8 109 15 a a DT cord-353298-vr5hnzp8 109 16 MEM MEM NNP cord-353298-vr5hnzp8 109 17 - - HYPH cord-353298-vr5hnzp8 109 18 Hepes Hepes NNP cord-353298-vr5hnzp8 109 19 buffer buffer NN cord-353298-vr5hnzp8 109 20 solution solution NN cord-353298-vr5hnzp8 109 21 ( ( -LRB- cord-353298-vr5hnzp8 109 22 0.1 0.1 CD cord-353298-vr5hnzp8 109 23 % % NN cord-353298-vr5hnzp8 109 24 gelatin gelatin NN cord-353298-vr5hnzp8 109 25 , , , cord-353298-vr5hnzp8 109 26 1 1 CD cord-353298-vr5hnzp8 109 27 % % NN cord-353298-vr5hnzp8 109 28 BSA BSA NNP cord-353298-vr5hnzp8 109 29 , , , cord-353298-vr5hnzp8 109 30 and and CC cord-353298-vr5hnzp8 109 31 0.05 0.05 CD cord-353298-vr5hnzp8 109 32 % % NN cord-353298-vr5hnzp8 109 33 sodium sodium NN cord-353298-vr5hnzp8 109 34 azide azide NN cord-353298-vr5hnzp8 109 35 in in IN cord-353298-vr5hnzp8 109 36 MEM MEM NNP cord-353298-vr5hnzp8 109 37 - - HYPH cord-353298-vr5hnzp8 109 38 Hepos Hepos NNP cord-353298-vr5hnzp8 109 39 ) ) -RRB- cord-353298-vr5hnzp8 109 40 and and CC cord-353298-vr5hnzp8 109 41 applied apply VBD cord-353298-vr5hnzp8 109 42 to to IN cord-353298-vr5hnzp8 109 43 the the DT cord-353298-vr5hnzp8 109 44 fixed fix VBN cord-353298-vr5hnzp8 109 45 cells cell NNS cord-353298-vr5hnzp8 109 46 for for IN cord-353298-vr5hnzp8 109 47 1 1 CD cord-353298-vr5hnzp8 109 48 - - SYM cord-353298-vr5hnzp8 109 49 2 2 CD cord-353298-vr5hnzp8 109 50 h. h. NN cord-353298-vr5hnzp8 109 51 04 04 CD cord-353298-vr5hnzp8 109 52 was be VBD cord-353298-vr5hnzp8 109 53 visualized visualize VBN cord-353298-vr5hnzp8 109 54 with with IN cord-353298-vr5hnzp8 109 55 rhodamine rhodamine JJ cord-353298-vr5hnzp8 109 56 conjugated conjugate VBN cord-353298-vr5hnzp8 109 57 goat goat NNP cord-353298-vr5hnzp8 109 58 antimouse antimouse NNP cord-353298-vr5hnzp8 109 59 IgM IgM NNP cord-353298-vr5hnzp8 109 60 ( ( -LRB- cord-353298-vr5hnzp8 109 61 25 25 CD cord-353298-vr5hnzp8 109 62 t t NN cord-353298-vr5hnzp8 109 63 ~ ~ CD cord-353298-vr5hnzp8 109 64 g g NNP cord-353298-vr5hnzp8 109 65 / / SYM cord-353298-vr5hnzp8 109 66 mi mi NNP cord-353298-vr5hnzp8 109 67 ; ; : cord-353298-vr5hnzp8 110 1 Jackson Jackson NNP cord-353298-vr5hnzp8 110 2 Immunoresearch Immunoresearch NNP cord-353298-vr5hnzp8 110 3 Laboratories Laboratories NNP cord-353298-vr5hnzp8 110 4 , , , cord-353298-vr5hnzp8 110 5 West West NNP cord-353298-vr5hnzp8 110 6 Grove Grove NNP cord-353298-vr5hnzp8 110 7 , , , cord-353298-vr5hnzp8 110 8 PA PA NNP cord-353298-vr5hnzp8 110 9 ) ) -RRB- cord-353298-vr5hnzp8 110 10 . . . cord-353298-vr5hnzp8 111 1 Anti Anti NNP cord-353298-vr5hnzp8 111 2 - - NNP cord-353298-vr5hnzp8 111 3 GC GC NNP cord-353298-vr5hnzp8 111 4 was be VBD cord-353298-vr5hnzp8 111 5 visualized visualize VBN cord-353298-vr5hnzp8 111 6 with with IN cord-353298-vr5hnzp8 111 7 fluorescein fluorescein JJ cord-353298-vr5hnzp8 111 8 conjugated conjugate VBN cord-353298-vr5hnzp8 111 9 goat goat NN cord-353298-vr5hnzp8 111 10 anti anti JJ cord-353298-vr5hnzp8 111 11 - - JJ cord-353298-vr5hnzp8 111 12 mouse mouse NN cord-353298-vr5hnzp8 111 13 IgG3 igg3 NN cord-353298-vr5hnzp8 111 14 ( ( -LRB- cord-353298-vr5hnzp8 111 15 16.6 16.6 CD cord-353298-vr5hnzp8 111 16 tzg tzg NNP cord-353298-vr5hnzp8 111 17 / / SYM cord-353298-vr5hnzp8 111 18 ml ml NN cord-353298-vr5hnzp8 111 19 ; ; : cord-353298-vr5hnzp8 111 20 Fischer Fischer NNP cord-353298-vr5hnzp8 111 21 Biotech Biotech NNP cord-353298-vr5hnzp8 111 22 , , , cord-353298-vr5hnzp8 111 23 Orangeburg Orangeburg NNP cord-353298-vr5hnzp8 111 24 , , , cord-353298-vr5hnzp8 111 25 NY NY NNP cord-353298-vr5hnzp8 111 26 ) ) -RRB- cord-353298-vr5hnzp8 111 27 . . . cord-353298-vr5hnzp8 112 1 These these DT cord-353298-vr5hnzp8 112 2 secondary secondary JJ cord-353298-vr5hnzp8 112 3 antibodies antibody NNS cord-353298-vr5hnzp8 112 4 were be VBD cord-353298-vr5hnzp8 112 5 also also RB cord-353298-vr5hnzp8 112 6 mixed mix VBN cord-353298-vr5hnzp8 112 7 together together RB cord-353298-vr5hnzp8 112 8 in in IN cord-353298-vr5hnzp8 112 9 MEM MEM NNP cord-353298-vr5hnzp8 112 10 - - HYPH cord-353298-vr5hnzp8 112 11 Hepes Hepes NNP cord-353298-vr5hnzp8 112 12 buffer buffer NN cord-353298-vr5hnzp8 112 13 solution solution NN cord-353298-vr5hnzp8 112 14 and and CC cord-353298-vr5hnzp8 112 15 applied apply VBD cord-353298-vr5hnzp8 112 16 for for IN cord-353298-vr5hnzp8 112 17 1 1 CD cord-353298-vr5hnzp8 112 18 - - SYM cord-353298-vr5hnzp8 112 19 2 2 CD cord-353298-vr5hnzp8 112 20 h. h. NN cord-353298-vr5hnzp8 113 1 After after IN cord-353298-vr5hnzp8 113 2 washing washing NN cord-353298-vr5hnzp8 113 3 , , , cord-353298-vr5hnzp8 113 4 the the DT cord-353298-vr5hnzp8 113 5 cultures culture NNS cord-353298-vr5hnzp8 113 6 were be VBD cord-353298-vr5hnzp8 113 7 fixed fix VBN cord-353298-vr5hnzp8 113 8 with with IN cord-353298-vr5hnzp8 113 9 5 5 CD cord-353298-vr5hnzp8 113 10 % % NN cord-353298-vr5hnzp8 113 11 glacial glacial JJ cord-353298-vr5hnzp8 113 12 acetic acetic JJ cord-353298-vr5hnzp8 113 13 acid acid NN cord-353298-vr5hnzp8 113 14 in in IN cord-353298-vr5hnzp8 113 15 ethanol ethanol NN cord-353298-vr5hnzp8 113 16 for for IN cord-353298-vr5hnzp8 113 17 10 10 CD cord-353298-vr5hnzp8 113 18 min min NN cord-353298-vr5hnzp8 113 19 at at IN cord-353298-vr5hnzp8 113 20 -20"C -20"c ADD cord-353298-vr5hnzp8 113 21 to to TO cord-353298-vr5hnzp8 113 22 expose expose VB cord-353298-vr5hnzp8 113 23 internal internal JJ cord-353298-vr5hnzp8 113 24 cellular cellular JJ cord-353298-vr5hnzp8 113 25 antigens antigen NNS cord-353298-vr5hnzp8 113 26 . . . cord-353298-vr5hnzp8 114 1 This this DT cord-353298-vr5hnzp8 114 2 was be VBD cord-353298-vr5hnzp8 114 3 followed follow VBN cord-353298-vr5hnzp8 114 4 by by IN cord-353298-vr5hnzp8 114 5 three three CD cord-353298-vr5hnzp8 114 6 washes wash NNS cord-353298-vr5hnzp8 114 7 in in IN cord-353298-vr5hnzp8 114 8 10 10 CD cord-353298-vr5hnzp8 114 9 % % NN cord-353298-vr5hnzp8 114 10 FBS FBS NNP cord-353298-vr5hnzp8 114 11 MEM MEM NNP cord-353298-vr5hnzp8 114 12 - - HYPH cord-353298-vr5hnzp8 114 13 Hepes Hepes NNP cord-353298-vr5hnzp8 114 14 and and CC cord-353298-vr5hnzp8 114 15 three three CD cord-353298-vr5hnzp8 114 16 washes wash NNS cord-353298-vr5hnzp8 114 17 in in IN cord-353298-vr5hnzp8 114 18 0.5 0.5 CD cord-353298-vr5hnzp8 114 19 M M NNP cord-353298-vr5hnzp8 114 20 Tris Tris NNP cord-353298-vr5hnzp8 114 21 buffer buffer NN cord-353298-vr5hnzp8 114 22 . . . cord-353298-vr5hnzp8 115 1 Polyclonal Polyclonal NNP cord-353298-vr5hnzp8 115 2 rabbit rabbit NN cord-353298-vr5hnzp8 115 3 anti anti NNP cord-353298-vr5hnzp8 115 4 - - NNP cord-353298-vr5hnzp8 115 5 GFAP GFAP NNP cord-353298-vr5hnzp8 115 6 was be VBD cord-353298-vr5hnzp8 115 7 diluted dilute VBN cord-353298-vr5hnzp8 115 8 1:2,000 1:2,000 CD cord-353298-vr5hnzp8 115 9 in in IN cord-353298-vr5hnzp8 115 10 a a DT cord-353298-vr5hnzp8 115 11 Tris Tris NNP cord-353298-vr5hnzp8 115 12 buffer buffer NN cord-353298-vr5hnzp8 115 13 solution solution NN cord-353298-vr5hnzp8 115 14 ( ( -LRB- cord-353298-vr5hnzp8 115 15 0.1 0.1 CD cord-353298-vr5hnzp8 115 16 % % NN cord-353298-vr5hnzp8 115 17 gelatin gelatin NN cord-353298-vr5hnzp8 115 18 , , , cord-353298-vr5hnzp8 115 19 1 1 CD cord-353298-vr5hnzp8 115 20 % % NN cord-353298-vr5hnzp8 115 21 BSA BSA NNP cord-353298-vr5hnzp8 115 22 , , , cord-353298-vr5hnzp8 115 23 and and CC cord-353298-vr5hnzp8 115 24 0.05 0.05 CD cord-353298-vr5hnzp8 115 25 % % NN cord-353298-vr5hnzp8 115 26 sodium sodium NN cord-353298-vr5hnzp8 115 27 azide azide NN cord-353298-vr5hnzp8 115 28 in in IN cord-353298-vr5hnzp8 115 29 0.5 0.5 CD cord-353298-vr5hnzp8 115 30 M M NNP cord-353298-vr5hnzp8 115 31 Tris Tris NNP cord-353298-vr5hnzp8 115 32 buffer buffer NN cord-353298-vr5hnzp8 115 33 ) ) -RRB- cord-353298-vr5hnzp8 115 34 for for IN cord-353298-vr5hnzp8 115 35 binding bind VBG cord-353298-vr5hnzp8 115 36 overnight overnight RB cord-353298-vr5hnzp8 115 37 at at IN cord-353298-vr5hnzp8 115 38 4"C. 4"c. CD cord-353298-vr5hnzp8 115 39 Anti Anti NNP cord-353298-vr5hnzp8 115 40 - - NNP cord-353298-vr5hnzp8 115 41 GFAP GFAP NNP cord-353298-vr5hnzp8 115 42 was be VBD cord-353298-vr5hnzp8 115 43 visualized visualize VBN cord-353298-vr5hnzp8 115 44 with with IN cord-353298-vr5hnzp8 115 45 biotinylated biotinylated JJ cord-353298-vr5hnzp8 115 46 donkey donkey NNP cord-353298-vr5hnzp8 115 47 anti anti JJ cord-353298-vr5hnzp8 115 48 - - JJ cord-353298-vr5hnzp8 115 49 rabbit rabbit JJ cord-353298-vr5hnzp8 115 50 IgG igg NN cord-353298-vr5hnzp8 115 51 ( ( -LRB- cord-353298-vr5hnzp8 115 52 10/~g 10/~g NNP cord-353298-vr5hnzp8 115 53 / / SYM cord-353298-vr5hnzp8 115 54 ml ml XX cord-353298-vr5hnzp8 115 55 in in IN cord-353298-vr5hnzp8 115 56 the the DT cord-353298-vr5hnzp8 115 57 Tris Tris NNP cord-353298-vr5hnzp8 115 58 buffer buffer NN cord-353298-vr5hnzp8 115 59 solution solution NN cord-353298-vr5hnzp8 115 60 , , , cord-353298-vr5hnzp8 115 61 1 1 CD cord-353298-vr5hnzp8 115 62 - - SYM cord-353298-vr5hnzp8 115 63 2 2 CD cord-353298-vr5hnzp8 115 64 h h NN cord-353298-vr5hnzp8 115 65 ; ; : cord-353298-vr5hnzp8 115 66 Amersham Amersham NNP cord-353298-vr5hnzp8 115 67 Chemical Chemical NNP cord-353298-vr5hnzp8 115 68 Co. Co. NNP cord-353298-vr5hnzp8 115 69 , , , cord-353298-vr5hnzp8 115 70 Arlington Arlington NNP cord-353298-vr5hnzp8 115 71 Heights Heights NNP cord-353298-vr5hnzp8 115 72 , , , cord-353298-vr5hnzp8 115 73 IL IL NNP cord-353298-vr5hnzp8 115 74 ) ) -RRB- cord-353298-vr5hnzp8 115 75 followed follow VBN cord-353298-vr5hnzp8 115 76 by by IN cord-353298-vr5hnzp8 116 1 streptavidin streptavidin NNP cord-353298-vr5hnzp8 116 2 conjugated conjugate VBD cord-353298-vr5hnzp8 116 3 7-amino-4-methyl 7-amino-4-methyl CD cord-353298-vr5hnzp8 116 4 - - HYPH cord-353298-vr5hnzp8 116 5 coumarin-3-acetic coumarin-3-acetic JJ cord-353298-vr5hnzp8 116 6 acid acid NN cord-353298-vr5hnzp8 116 7 ( ( -LRB- cord-353298-vr5hnzp8 116 8 25 25 CD cord-353298-vr5hnzp8 116 9 / / SYM cord-353298-vr5hnzp8 116 10 zg/ zg/ CD cord-353298-vr5hnzp8 116 11 ml ml NN cord-353298-vr5hnzp8 116 12 in in IN cord-353298-vr5hnzp8 116 13 the the DT cord-353298-vr5hnzp8 116 14 Tris Tris NNP cord-353298-vr5hnzp8 116 15 buffer buffer NN cord-353298-vr5hnzp8 116 16 solution solution NN cord-353298-vr5hnzp8 116 17 , , , cord-353298-vr5hnzp8 116 18 1 1 CD cord-353298-vr5hnzp8 116 19 - - SYM cord-353298-vr5hnzp8 116 20 2 2 CD cord-353298-vr5hnzp8 116 21 h h NN cord-353298-vr5hnzp8 116 22 ; ; : cord-353298-vr5hnzp8 116 23 Molecular Molecular NNP cord-353298-vr5hnzp8 116 24 Probes Probes NNPS cord-353298-vr5hnzp8 116 25 , , , cord-353298-vr5hnzp8 116 26 Inc. Inc. NNP cord-353298-vr5hnzp8 116 27 , , , cord-353298-vr5hnzp8 116 28 Eugene Eugene NNP cord-353298-vr5hnzp8 116 29 , , , cord-353298-vr5hnzp8 116 30 OR or CC cord-353298-vr5hnzp8 116 31 ; ; : cord-353298-vr5hnzp8 116 32 Khallhn Khallhn NNP cord-353298-vr5hnzp8 116 33 etal etal NNP cord-353298-vr5hnzp8 116 34 . . NNP cord-353298-vr5hnzp8 116 35 , , , cord-353298-vr5hnzp8 116 36 1986 1986 CD cord-353298-vr5hnzp8 116 37 ) ) -RRB- cord-353298-vr5hnzp8 116 38 . . . cord-353298-vr5hnzp8 117 1 Atter Atter NNP cord-353298-vr5hnzp8 117 2 a a DT cord-353298-vr5hnzp8 117 3 final final JJ cord-353298-vr5hnzp8 117 4 5-rain 5-rain CD cord-353298-vr5hnzp8 117 5 fixation fixation NN cord-353298-vr5hnzp8 117 6 in in IN cord-353298-vr5hnzp8 117 7 4 4 CD cord-353298-vr5hnzp8 117 8 % % NN cord-353298-vr5hnzp8 117 9 paraformaldeh)de paraformaldeh)de NN cord-353298-vr5hnzp8 117 10 the the DT cord-353298-vr5hnzp8 117 11 cultures culture NNS cord-353298-vr5hnzp8 117 12 were be VBD cord-353298-vr5hnzp8 117 13 either either CC cord-353298-vr5hnzp8 117 14 coverslipped coverslipped NNS cord-353298-vr5hnzp8 117 15 , , , cord-353298-vr5hnzp8 117 16 with with IN cord-353298-vr5hnzp8 117 17 a a DT cord-353298-vr5hnzp8 117 18 solution solution NN cord-353298-vr5hnzp8 117 19 of of IN cord-353298-vr5hnzp8 117 20 20 20 CD cord-353298-vr5hnzp8 117 21 % % NN cord-353298-vr5hnzp8 117 22 0.02 0.02 CD cord-353298-vr5hnzp8 117 23 M M NNP cord-353298-vr5hnzp8 117 24 Tris Tris NNP cord-353298-vr5hnzp8 117 25 buffer buffer NN cord-353298-vr5hnzp8 117 26 ( ( -LRB- cord-353298-vr5hnzp8 117 27 pH pH NNP cord-353298-vr5hnzp8 117 28 8.2 8.2 CD cord-353298-vr5hnzp8 117 29 ) ) -RRB- cord-353298-vr5hnzp8 117 30 and and CC cord-353298-vr5hnzp8 117 31 80 80 CD cord-353298-vr5hnzp8 117 32 % % NN cord-353298-vr5hnzp8 117 33 glycerol glycerol NN cord-353298-vr5hnzp8 117 34 , , , cord-353298-vr5hnzp8 117 35 or or CC cord-353298-vr5hnzp8 117 36 processed process VBN cord-353298-vr5hnzp8 117 37 for for IN cord-353298-vr5hnzp8 117 38 autoradiography autoradiography NNP cord-353298-vr5hnzp8 117 39 ( ( -LRB- cord-353298-vr5hnzp8 117 40 see see VB cord-353298-vr5hnzp8 117 41 below below RB cord-353298-vr5hnzp8 117 42 ) ) -RRB- cord-353298-vr5hnzp8 117 43 . . . cord-353298-vr5hnzp8 118 1 Immunostained immunostained JJ cord-353298-vr5hnzp8 118 2 cells cell NNS cord-353298-vr5hnzp8 118 3 were be VBD cord-353298-vr5hnzp8 118 4 examined examine VBN cord-353298-vr5hnzp8 118 5 by by IN cord-353298-vr5hnzp8 118 6 epifluorescence epifluorescence NN cord-353298-vr5hnzp8 118 7 with with IN cord-353298-vr5hnzp8 118 8 a a DT cord-353298-vr5hnzp8 118 9 Zeiss Zeiss NNP cord-353298-vr5hnzp8 118 10 Photoscopo Photoscopo NNP cord-353298-vr5hnzp8 118 11 I11 I11 NNP cord-353298-vr5hnzp8 118 12 equipped equip VBD cord-353298-vr5hnzp8 118 13 with with IN cord-353298-vr5hnzp8 118 14 three three CD cord-353298-vr5hnzp8 118 15 filter filter NN cord-353298-vr5hnzp8 118 16 sets set NNS cord-353298-vr5hnzp8 118 17 to to TO cord-353298-vr5hnzp8 118 18 simultaneously simultaneously RB cord-353298-vr5hnzp8 118 19 view view VB cord-353298-vr5hnzp8 118 20 rhodamine rhodamine NN cord-353298-vr5hnzp8 118 21 , , , cord-353298-vr5hnzp8 118 22 fluorescein fluorescein NN cord-353298-vr5hnzp8 118 23 , , , cord-353298-vr5hnzp8 118 24 and and CC cord-353298-vr5hnzp8 118 25 coumarin coumarin NN cord-353298-vr5hnzp8 118 26 fluorescence fluorescence NN cord-353298-vr5hnzp8 118 27 . . . cord-353298-vr5hnzp8 119 1 The the DT cord-353298-vr5hnzp8 119 2 absence absence NN cord-353298-vr5hnzp8 119 3 of of IN cord-353298-vr5hnzp8 119 4 cross cross JJ cord-353298-vr5hnzp8 119 5 - - NN cord-353298-vr5hnzp8 119 6 reaction reaction NN cord-353298-vr5hnzp8 119 7 in in IN cord-353298-vr5hnzp8 119 8 the the DT cord-353298-vr5hnzp8 119 9 three three CD cord-353298-vr5hnzp8 119 10 - - HYPH cord-353298-vr5hnzp8 119 11 color color NN cord-353298-vr5hnzp8 119 12 immunofluorescence immunofluorescence NN cord-353298-vr5hnzp8 119 13 protocol protocol NN cord-353298-vr5hnzp8 119 14 was be VBD cord-353298-vr5hnzp8 119 15 tested test VBN cord-353298-vr5hnzp8 119 16 by by IN cord-353298-vr5hnzp8 119 17 omitting omit VBG cord-353298-vr5hnzp8 119 18 , , , cord-353298-vr5hnzp8 119 19 in in IN cord-353298-vr5hnzp8 119 20 turn turn NN cord-353298-vr5hnzp8 119 21 , , , cord-353298-vr5hnzp8 119 22 each each DT cord-353298-vr5hnzp8 119 23 one one CD cord-353298-vr5hnzp8 119 24 of of IN cord-353298-vr5hnzp8 119 25 the the DT cord-353298-vr5hnzp8 119 26 three three CD cord-353298-vr5hnzp8 119 27 primary primary JJ cord-353298-vr5hnzp8 119 28 antibodies antibody NNS cord-353298-vr5hnzp8 119 29 while while IN cord-353298-vr5hnzp8 119 30 all all DT cord-353298-vr5hnzp8 119 31 other other JJ cord-353298-vr5hnzp8 119 32 steps step NNS cord-353298-vr5hnzp8 119 33 remained remain VBD cord-353298-vr5hnzp8 119 34 unchanged unchanged JJ cord-353298-vr5hnzp8 119 35 . . . cord-353298-vr5hnzp8 120 1 Omission omission NN cord-353298-vr5hnzp8 120 2 of of IN cord-353298-vr5hnzp8 120 3 each each DT cord-353298-vr5hnzp8 120 4 primary primary JJ cord-353298-vr5hnzp8 120 5 completely completely RB cord-353298-vr5hnzp8 120 6 abolished abolish VBN cord-353298-vr5hnzp8 120 7 binding binding NN cord-353298-vr5hnzp8 120 8 of of IN cord-353298-vr5hnzp8 120 9 the the DT cord-353298-vr5hnzp8 120 10 corresponding corresponding JJ cord-353298-vr5hnzp8 120 11 secondary secondary JJ cord-353298-vr5hnzp8 120 12 but but CC cord-353298-vr5hnzp8 120 13 did do VBD cord-353298-vr5hnzp8 120 14 not not RB cord-353298-vr5hnzp8 120 15 affect affect VB cord-353298-vr5hnzp8 120 16 signals signal NNS cord-353298-vr5hnzp8 120 17 in in IN cord-353298-vr5hnzp8 120 18 the the DT cord-353298-vr5hnzp8 120 19 other other JJ cord-353298-vr5hnzp8 120 20 two two CD cord-353298-vr5hnzp8 120 21 channels channel NNS cord-353298-vr5hnzp8 120 22 . . . cord-353298-vr5hnzp8 121 1 In in IN cord-353298-vr5hnzp8 121 2 some some DT cord-353298-vr5hnzp8 121 3 cultures culture NNS cord-353298-vr5hnzp8 121 4 , , , cord-353298-vr5hnzp8 121 5 the the DT cord-353298-vr5hnzp8 121 6 presence presence NN cord-353298-vr5hnzp8 121 7 of of IN cord-353298-vr5hnzp8 121 8 mixed mixed JJ cord-353298-vr5hnzp8 121 9 oligodendrocyte oligodendrocyte NNP cord-353298-vr5hnzp8 121 10 - - HYPH cord-353298-vr5hnzp8 121 11 astrocyte astrocyte JJ cord-353298-vr5hnzp8 121 12 phenotype phenotype NN cord-353298-vr5hnzp8 121 13 cells cell NNS cord-353298-vr5hnzp8 121 14 was be VBD cord-353298-vr5hnzp8 121 15 confirmed confirm VBN cord-353298-vr5hnzp8 121 16 with with IN cord-353298-vr5hnzp8 121 17 a a DT cord-353298-vr5hnzp8 121 18 second second JJ cord-353298-vr5hnzp8 121 19 set set NN cord-353298-vr5hnzp8 121 20 of of IN cord-353298-vr5hnzp8 121 21 prirnary prirnary JJ cord-353298-vr5hnzp8 121 22 antibodies antibody NNS cord-353298-vr5hnzp8 121 23 . . . cord-353298-vr5hnzp8 122 1 These these DT cord-353298-vr5hnzp8 122 2 cultures culture NNS cord-353298-vr5hnzp8 122 3 were be VBD cord-353298-vr5hnzp8 122 4 immunostained immunostaine VBN cord-353298-vr5hnzp8 122 5 with with IN cord-353298-vr5hnzp8 122 6 04 04 CD cord-353298-vr5hnzp8 122 7 , , , cord-353298-vr5hnzp8 122 8 as as IN cord-353298-vr5hnzp8 122 9 described describe VBN cord-353298-vr5hnzp8 122 10 above above RB cord-353298-vr5hnzp8 122 11 , , , cord-353298-vr5hnzp8 122 12 in in IN cord-353298-vr5hnzp8 122 13 combination combination NN cord-353298-vr5hnzp8 122 14 with with IN cord-353298-vr5hnzp8 122 15 a a DT cord-353298-vr5hnzp8 122 16 rat rat NN cord-353298-vr5hnzp8 122 17 mAb mab NN cord-353298-vr5hnzp8 122 18 to to IN cord-353298-vr5hnzp8 122 19 GFAP GFAP NNP cord-353298-vr5hnzp8 123 1 ( ( -LRB- cord-353298-vr5hnzp8 123 2 Lee Lee NNP cord-353298-vr5hnzp8 123 3 et et NNP cord-353298-vr5hnzp8 123 4 al al NNP cord-353298-vr5hnzp8 123 5 . . NNP cord-353298-vr5hnzp8 123 6 , , , cord-353298-vr5hnzp8 123 7 1984 1984 CD cord-353298-vr5hnzp8 123 8 ) ) -RRB- cord-353298-vr5hnzp8 123 9 visualized visualize VBD cord-353298-vr5hnzp8 123 10 with with IN cord-353298-vr5hnzp8 123 11 fluorescein fluorescein NN cord-353298-vr5hnzp8 123 12 and and CC cord-353298-vr5hnzp8 123 13 a a DT cord-353298-vr5hnzp8 123 14 rabbit rabbit NN cord-353298-vr5hnzp8 123 15 polyclonal polyclonal JJ cord-353298-vr5hnzp8 123 16 antiserum antiserum NN cord-353298-vr5hnzp8 123 17 to to IN cord-353298-vr5hnzp8 123 18 GC GC NNP cord-353298-vr5hnzp8 123 19 , , , cord-353298-vr5hnzp8 123 20 which which WDT cord-353298-vr5hnzp8 123 21 was be VBD cord-353298-vr5hnzp8 123 22 produced produce VBN cord-353298-vr5hnzp8 123 23 in in IN cord-353298-vr5hnzp8 123 24 our -PRON- PRP$ cord-353298-vr5hnzp8 123 25 laboratory laboratory NN cord-353298-vr5hnzp8 123 26 ( ( -LRB- cord-353298-vr5hnzp8 123 27 according accord VBG cord-353298-vr5hnzp8 123 28 to to IN cord-353298-vr5hnzp8 123 29 the the DT cord-353298-vr5hnzp8 123 30 procedure procedure NN cord-353298-vr5hnzp8 123 31 described describe VBN cord-353298-vr5hnzp8 123 32 by by IN cord-353298-vr5hnzp8 123 33 Benjamins Benjamins NNP cord-353298-vr5hnzp8 123 34 et et NNP cord-353298-vr5hnzp8 123 35 al al NNP cord-353298-vr5hnzp8 123 36 . . NNP cord-353298-vr5hnzp8 123 37 , , , cord-353298-vr5hnzp8 123 38 1987 1987 CD cord-353298-vr5hnzp8 123 39 ) ) -RRB- cord-353298-vr5hnzp8 123 40 , , , cord-353298-vr5hnzp8 123 41 and and CC cord-353298-vr5hnzp8 123 42 visualized visualize VBN cord-353298-vr5hnzp8 123 43 with with IN cord-353298-vr5hnzp8 123 44 coumarin coumarin NN cord-353298-vr5hnzp8 123 45 . . . cord-353298-vr5hnzp8 124 1 A a DT cord-353298-vr5hnzp8 124 2 segment segment NN cord-353298-vr5hnzp8 124 3 of of IN cord-353298-vr5hnzp8 124 4 each each DT cord-353298-vr5hnzp8 124 5 spinal spinal JJ cord-353298-vr5hnzp8 124 6 cord cord NN cord-353298-vr5hnzp8 124 7 was be VBD cord-353298-vr5hnzp8 124 8 excised excise VBN cord-353298-vr5hnzp8 124 9 with with IN cord-353298-vr5hnzp8 124 10 a a DT cord-353298-vr5hnzp8 124 11 sterile sterile JJ cord-353298-vr5hnzp8 124 12 razor razor NN cord-353298-vr5hnzp8 124 13 blade blade NN cord-353298-vr5hnzp8 124 14 before before IN cord-353298-vr5hnzp8 124 15 glial glial JJ cord-353298-vr5hnzp8 124 16 cell cell NN cord-353298-vr5hnzp8 124 17 isolation isolation NN cord-353298-vr5hnzp8 124 18 . . . cord-353298-vr5hnzp8 125 1 Segments segment NNS cord-353298-vr5hnzp8 125 2 were be VBD cord-353298-vr5hnzp8 125 3 fixed fix VBN cord-353298-vr5hnzp8 125 4 by by IN cord-353298-vr5hnzp8 125 5 overnight overnight JJ cord-353298-vr5hnzp8 125 6 immersion immersion NN cord-353298-vr5hnzp8 125 7 in in IN cord-353298-vr5hnzp8 125 8 1 1 CD cord-353298-vr5hnzp8 125 9 % % NN cord-353298-vr5hnzp8 125 10 glutaraldehyde glutaraldehyde NN cord-353298-vr5hnzp8 125 11 and and CC cord-353298-vr5hnzp8 125 12 2 2 CD cord-353298-vr5hnzp8 125 13 % % NN cord-353298-vr5hnzp8 125 14 paraformaldehyde paraformaldehyde NN cord-353298-vr5hnzp8 125 15 in in IN cord-353298-vr5hnzp8 125 16 0.1 0.1 CD cord-353298-vr5hnzp8 125 17 M m NN cord-353298-vr5hnzp8 125 18 phosphate phosphate NN cord-353298-vr5hnzp8 125 19 buffer buffer NN cord-353298-vr5hnzp8 125 20 . . . cord-353298-vr5hnzp8 126 1 The the DT cord-353298-vr5hnzp8 126 2 tissue tissue NN cord-353298-vr5hnzp8 126 3 was be VBD cord-353298-vr5hnzp8 126 4 then then RB cord-353298-vr5hnzp8 126 5 washed wash VBN cord-353298-vr5hnzp8 126 6 for for IN cord-353298-vr5hnzp8 126 7 1 1 CD cord-353298-vr5hnzp8 126 8 d d NN cord-353298-vr5hnzp8 126 9 in in IN cord-353298-vr5hnzp8 126 10 buffer buffer NN cord-353298-vr5hnzp8 126 11 , , , cord-353298-vr5hnzp8 126 12 postfixed postfixed JJ cord-353298-vr5hnzp8 126 13 with with IN cord-353298-vr5hnzp8 126 14 2 2 CD cord-353298-vr5hnzp8 126 15 % % NN cord-353298-vr5hnzp8 126 16 osmium osmium NN cord-353298-vr5hnzp8 126 17 tetmxide tetmxide NN cord-353298-vr5hnzp8 126 18 for for IN cord-353298-vr5hnzp8 126 19 2 2 CD cord-353298-vr5hnzp8 126 20 h h NN cord-353298-vr5hnzp8 126 21 , , , cord-353298-vr5hnzp8 126 22 dehydrated dehydrate VBN cord-353298-vr5hnzp8 126 23 in in IN cord-353298-vr5hnzp8 126 24 graded grade VBN cord-353298-vr5hnzp8 126 25 alcohols alcohol NNS cord-353298-vr5hnzp8 126 26 , , , cord-353298-vr5hnzp8 126 27 cleared clear VBN cord-353298-vr5hnzp8 126 28 with with IN cord-353298-vr5hnzp8 126 29 propylene propylene NN cord-353298-vr5hnzp8 126 30 oxide oxide NN cord-353298-vr5hnzp8 126 31 , , , cord-353298-vr5hnzp8 126 32 and and CC cord-353298-vr5hnzp8 126 33 embedded embed VBN cord-353298-vr5hnzp8 126 34 in in IN cord-353298-vr5hnzp8 126 35 Epon Epon NNP cord-353298-vr5hnzp8 126 36 resin resin NN cord-353298-vr5hnzp8 126 37 . . . cord-353298-vr5hnzp8 127 1 Transverse transverse JJ cord-353298-vr5hnzp8 127 2 sections section NNS cord-353298-vr5hnzp8 127 3 ( ( -LRB- cord-353298-vr5hnzp8 127 4 1 1 CD cord-353298-vr5hnzp8 127 5 ~m ~m JJ cord-353298-vr5hnzp8 127 6 ) ) -RRB- cord-353298-vr5hnzp8 127 7 were be VBD cord-353298-vr5hnzp8 127 8 stained stain VBN cord-353298-vr5hnzp8 127 9 with with IN cord-353298-vr5hnzp8 127 10 toluidine toluidine NNP cord-353298-vr5hnzp8 127 11 blue blue NNP cord-353298-vr5hnzp8 127 12 . . . cord-353298-vr5hnzp8 128 1 Cultured cultured JJ cord-353298-vr5hnzp8 128 2 cells cell NNS cord-353298-vr5hnzp8 128 3 , , , cord-353298-vr5hnzp8 128 4 labeled label VBN cord-353298-vr5hnzp8 128 5 either either CC cord-353298-vr5hnzp8 128 6 in in IN cord-353298-vr5hnzp8 128 7 vivo vivo NN cord-353298-vr5hnzp8 128 8 or or CC cord-353298-vr5hnzp8 128 9 in in IN cord-353298-vr5hnzp8 128 10 vitro vitro FW cord-353298-vr5hnzp8 128 11 with with IN cord-353298-vr5hnzp8 128 12 [ [ -LRB- cord-353298-vr5hnzp8 128 13 3H]thymidine 3h]thymidine CD cord-353298-vr5hnzp8 128 14 , , , cord-353298-vr5hnzp8 128 15 were be VBD cord-353298-vr5hnzp8 128 16 immunostained immunostaine VBN cord-353298-vr5hnzp8 128 17 and and CC cord-353298-vr5hnzp8 128 18 post post JJ cord-353298-vr5hnzp8 128 19 - - JJ cord-353298-vr5hnzp8 128 20 fixed fix VBN cord-353298-vr5hnzp8 128 21 as as IN cord-353298-vr5hnzp8 128 22 described describe VBN cord-353298-vr5hnzp8 128 23 above above RB cord-353298-vr5hnzp8 128 24 . . . cord-353298-vr5hnzp8 129 1 The the DT cord-353298-vr5hnzp8 129 2 specimens specimen NNS cord-353298-vr5hnzp8 129 3 were be VBD cord-353298-vr5hnzp8 129 4 then then RB cord-353298-vr5hnzp8 129 5 dehydrated dehydrate VBN cord-353298-vr5hnzp8 129 6 in in IN cord-353298-vr5hnzp8 129 7 graded grade VBN cord-353298-vr5hnzp8 129 8 alcohols alcohol NNS cord-353298-vr5hnzp8 129 9 ( ( -LRB- cord-353298-vr5hnzp8 129 10 50 50 CD cord-353298-vr5hnzp8 129 11 % % NN cord-353298-vr5hnzp8 129 12 , , , cord-353298-vr5hnzp8 129 13 75 75 CD cord-353298-vr5hnzp8 129 14 % % NN cord-353298-vr5hnzp8 129 15 , , , cord-353298-vr5hnzp8 129 16 95 95 CD cord-353298-vr5hnzp8 129 17 % % NN cord-353298-vr5hnzp8 129 18 ; ; : cord-353298-vr5hnzp8 129 19 30 30 CD cord-353298-vr5hnzp8 129 20 seconds second NNS cord-353298-vr5hnzp8 129 21 in in IN cord-353298-vr5hnzp8 129 22 each each DT cord-353298-vr5hnzp8 129 23 ) ) -RRB- cord-353298-vr5hnzp8 129 24 , , , cord-353298-vr5hnzp8 129 25 air air NN cord-353298-vr5hnzp8 129 26 dried dry VBN cord-353298-vr5hnzp8 129 27 , , , cord-353298-vr5hnzp8 129 28 coated coat VBN cord-353298-vr5hnzp8 129 29 with with IN cord-353298-vr5hnzp8 129 30 Kodak Kodak NNP cord-353298-vr5hnzp8 129 31 NTB2 NTB2 NNP cord-353298-vr5hnzp8 129 32 nuclear nuclear JJ cord-353298-vr5hnzp8 129 33 track track NN cord-353298-vr5hnzp8 129 34 emulsion emulsion NN cord-353298-vr5hnzp8 129 35 ( ( -LRB- cord-353298-vr5hnzp8 129 36 diluted dilute VBN cord-353298-vr5hnzp8 129 37 1:2 1:2 CD cord-353298-vr5hnzp8 129 38 ) ) -RRB- cord-353298-vr5hnzp8 129 39 , , , cord-353298-vr5hnzp8 129 40 exposed expose VBN cord-353298-vr5hnzp8 129 41 at at IN cord-353298-vr5hnzp8 129 42 4 4 CD cord-353298-vr5hnzp8 129 43 ° ° NN cord-353298-vr5hnzp8 129 44 C c NN cord-353298-vr5hnzp8 129 45 for for IN cord-353298-vr5hnzp8 129 46 5 5 CD cord-353298-vr5hnzp8 129 47 d d NN cord-353298-vr5hnzp8 129 48 , , , cord-353298-vr5hnzp8 129 49 developed develop VBN cord-353298-vr5hnzp8 129 50 at at IN cord-353298-vr5hnzp8 129 51 16 16 CD cord-353298-vr5hnzp8 129 52 ° ° NN cord-353298-vr5hnzp8 129 53 C c NN cord-353298-vr5hnzp8 129 54 in in IN cord-353298-vr5hnzp8 129 55 Kodak Kodak NNP cord-353298-vr5hnzp8 129 56 D19 D19 NNP cord-353298-vr5hnzp8 129 57 , , , cord-353298-vr5hnzp8 129 58 and and CC cord-353298-vr5hnzp8 129 59 fixed fix VBN cord-353298-vr5hnzp8 129 60 with with IN cord-353298-vr5hnzp8 129 61 Kodak Kodak NNP cord-353298-vr5hnzp8 129 62 fixer fixer NN cord-353298-vr5hnzp8 129 63 . . . cord-353298-vr5hnzp8 130 1 After after IN cord-353298-vr5hnzp8 130 2 several several JJ cord-353298-vr5hnzp8 130 3 washes wash NNS cord-353298-vr5hnzp8 130 4 , , , cord-353298-vr5hnzp8 130 5 cultures culture NNS cord-353298-vr5hnzp8 130 6 were be VBD cord-353298-vr5hnzp8 130 7 coverslipped coverslippe VBN cord-353298-vr5hnzp8 130 8 as as IN cord-353298-vr5hnzp8 130 9 described describe VBN cord-353298-vr5hnzp8 130 10 above above RB cord-353298-vr5hnzp8 130 11 . . . cord-353298-vr5hnzp8 130 12 _SP cord-353298-vr5hnzp8 131 1 The the DT cord-353298-vr5hnzp8 131 2 glial glial JJ cord-353298-vr5hnzp8 131 3 cell cell NN cord-353298-vr5hnzp8 131 4 population population NN cord-353298-vr5hnzp8 131 5 was be VBD cord-353298-vr5hnzp8 131 6 characterized characterize VBN cord-353298-vr5hnzp8 131 7 using use VBG cord-353298-vr5hnzp8 131 8 three three CD cord-353298-vr5hnzp8 131 9 - - HYPH cord-353298-vr5hnzp8 131 10 color color NN cord-353298-vr5hnzp8 131 11 immunofluorescence immunofluorescence NN cord-353298-vr5hnzp8 131 12 which which WDT cord-353298-vr5hnzp8 131 13 enabled enable VBD cord-353298-vr5hnzp8 131 14 simultaneous simultaneous JJ cord-353298-vr5hnzp8 131 15 visualization visualization NN cord-353298-vr5hnzp8 131 16 of of IN cord-353298-vr5hnzp8 131 17 three three CD cord-353298-vr5hnzp8 131 18 antigens antigen NNS cord-353298-vr5hnzp8 131 19 , , , cord-353298-vr5hnzp8 131 20 each each DT cord-353298-vr5hnzp8 131 21 labeled label VBN cord-353298-vr5hnzp8 131 22 by by IN cord-353298-vr5hnzp8 131 23 one one CD cord-353298-vr5hnzp8 131 24 of of IN cord-353298-vr5hnzp8 131 25 three three CD cord-353298-vr5hnzp8 131 26 different different JJ cord-353298-vr5hnzp8 131 27 fluorochromes fluorochrome NNS cord-353298-vr5hnzp8 131 28 ( ( -LRB- cord-353298-vr5hnzp8 131 29 rhodamine rhodamine NN cord-353298-vr5hnzp8 131 30 , , , cord-353298-vr5hnzp8 131 31 fluorescein fluorescein NN cord-353298-vr5hnzp8 131 32 , , , cord-353298-vr5hnzp8 131 33 or or CC cord-353298-vr5hnzp8 131 34 coumarin coumarin NN cord-353298-vr5hnzp8 131 35 ) ) -RRB- cord-353298-vr5hnzp8 131 36 . . . cord-353298-vr5hnzp8 132 1 Oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 132 2 were be VBD cord-353298-vr5hnzp8 132 3 identified identify VBN cord-353298-vr5hnzp8 132 4 by by IN cord-353298-vr5hnzp8 132 5 expression expression NN cord-353298-vr5hnzp8 132 6 of of IN cord-353298-vr5hnzp8 132 7 cell cell NN cord-353298-vr5hnzp8 132 8 surface surface NN cord-353298-vr5hnzp8 132 9 antigens antigen NNS cord-353298-vr5hnzp8 132 10 recognized recognize VBN cord-353298-vr5hnzp8 132 11 by by IN cord-353298-vr5hnzp8 132 12 anti anti JJ cord-353298-vr5hnzp8 132 13 - - JJ cord-353298-vr5hnzp8 132 14 GC gc JJ cord-353298-vr5hnzp8 132 15 ( ( -LRB- cord-353298-vr5hnzp8 132 16 Raft Raft NNP cord-353298-vr5hnzp8 132 17 et et NNP cord-353298-vr5hnzp8 132 18 al al NNP cord-353298-vr5hnzp8 132 19 . . NNP cord-353298-vr5hnzp8 132 20 , , , cord-353298-vr5hnzp8 132 21 1978 1978 CD cord-353298-vr5hnzp8 132 22 ) ) -RRB- cord-353298-vr5hnzp8 132 23 , , , cord-353298-vr5hnzp8 132 24 Cells cell NNS cord-353298-vr5hnzp8 132 25 containing contain VBG cord-353298-vr5hnzp8 132 26 intracellular intracellular JJ cord-353298-vr5hnzp8 132 27 filaments filament NNS cord-353298-vr5hnzp8 132 28 immunostained immunostaine VBN cord-353298-vr5hnzp8 132 29 with with IN cord-353298-vr5hnzp8 132 30 anti anti JJ cord-353298-vr5hnzp8 132 31 - - NNS cord-353298-vr5hnzp8 132 32 GFAP GFAP NNP cord-353298-vr5hnzp8 132 33 were be VBD cord-353298-vr5hnzp8 132 34 classified classify VBN cord-353298-vr5hnzp8 132 35 as as IN cord-353298-vr5hnzp8 132 36 astrocytes astrocyte NNS cord-353298-vr5hnzp8 132 37 ( ( -LRB- cord-353298-vr5hnzp8 132 38 Biguami Biguami NNP cord-353298-vr5hnzp8 132 39 et et NNP cord-353298-vr5hnzp8 132 40 al al NNP cord-353298-vr5hnzp8 132 41 . . NNP cord-353298-vr5hnzp8 132 42 , , , cord-353298-vr5hnzp8 132 43 1972 1972 CD cord-353298-vr5hnzp8 132 44 ; ; : cord-353298-vr5hnzp8 132 45 Rafter Rafter NNP cord-353298-vr5hnzp8 132 46 al al NNP cord-353298-vr5hnzp8 132 47 . . NNP cord-353298-vr5hnzp8 132 48 , , , cord-353298-vr5hnzp8 132 49 1979 1979 CD cord-353298-vr5hnzp8 132 50 ) ) -RRB- cord-353298-vr5hnzp8 132 51 . . . cord-353298-vr5hnzp8 133 1 Type type NN cord-353298-vr5hnzp8 133 2 2 2 CD cord-353298-vr5hnzp8 133 3 astrocytes astrocyte NNS cord-353298-vr5hnzp8 133 4 were be VBD cord-353298-vr5hnzp8 133 5 distinguished distinguish VBN cord-353298-vr5hnzp8 133 6 from from IN cord-353298-vr5hnzp8 133 7 type type NN cord-353298-vr5hnzp8 133 8 1 1 CD cord-353298-vr5hnzp8 133 9 astrocytes astrocyte NNS cord-353298-vr5hnzp8 133 10 by by IN cord-353298-vr5hnzp8 133 11 the the DT cord-353298-vr5hnzp8 133 12 expression expression NN cord-353298-vr5hnzp8 133 13 of of IN cord-353298-vr5hnzp8 133 14 cell cell NN cord-353298-vr5hnzp8 133 15 surface surface NN cord-353298-vr5hnzp8 133 16 antigens antigen NNS cord-353298-vr5hnzp8 133 17 recognized recognize VBN cord-353298-vr5hnzp8 133 18 by by IN cord-353298-vr5hnzp8 133 19 the the DT cord-353298-vr5hnzp8 133 20 04 04 CD cord-353298-vr5hnzp8 133 21 antibody antibody NN cord-353298-vr5hnzp8 133 22 ( ( -LRB- cord-353298-vr5hnzp8 133 23 Trotter Trotter NNP cord-353298-vr5hnzp8 133 24 and and CC cord-353298-vr5hnzp8 133 25 Schachner Schachner NNP cord-353298-vr5hnzp8 133 26 , , , cord-353298-vr5hnzp8 133 27 1989 1989 CD cord-353298-vr5hnzp8 133 28 ) ) -RRB- cord-353298-vr5hnzp8 133 29 . . . cord-353298-vr5hnzp8 134 1 O-2A O-2A NNP cord-353298-vr5hnzp8 134 2 progenitors progenitor NNS cord-353298-vr5hnzp8 134 3 derived derive VBN cord-353298-vr5hnzp8 134 4 from from IN cord-353298-vr5hnzp8 134 5 adult adult NN cord-353298-vr5hnzp8 134 6 CNS CNS NNP cord-353298-vr5hnzp8 134 7 were be VBD cord-353298-vr5hnzp8 134 8 identified identify VBN cord-353298-vr5hnzp8 134 9 as as IN cord-353298-vr5hnzp8 134 10 cells cell NNS cord-353298-vr5hnzp8 134 11 binding bind VBG cord-353298-vr5hnzp8 134 12 04 04 CD cord-353298-vr5hnzp8 134 13 in in IN cord-353298-vr5hnzp8 134 14 the the DT cord-353298-vr5hnzp8 134 15 absence absence NN cord-353298-vr5hnzp8 134 16 of of IN cord-353298-vr5hnzp8 134 17 GC GC NNP cord-353298-vr5hnzp8 134 18 or or CC cord-353298-vr5hnzp8 134 19 GFAP GFAP NNP cord-353298-vr5hnzp8 134 20 immunolabeling immunolabele VBG cord-353298-vr5hnzp8 134 21 ( ( -LRB- cord-353298-vr5hnzp8 134 22 Wolswijk Wolswijk NNP cord-353298-vr5hnzp8 134 23 and and CC cord-353298-vr5hnzp8 134 24 Noble Noble NNP cord-353298-vr5hnzp8 134 25 , , , cord-353298-vr5hnzp8 134 26 1989 1989 CD cord-353298-vr5hnzp8 134 27 ) ) -RRB- cord-353298-vr5hnzp8 134 28 . . . cord-353298-vr5hnzp8 135 1 Thus thus RB cord-353298-vr5hnzp8 135 2 , , , cord-353298-vr5hnzp8 135 3 any any DT cord-353298-vr5hnzp8 135 4 particular particular JJ cord-353298-vr5hnzp8 135 5 cell cell NN cord-353298-vr5hnzp8 135 6 could could MD cord-353298-vr5hnzp8 135 7 be be VB cord-353298-vr5hnzp8 135 8 identified identify VBN cord-353298-vr5hnzp8 135 9 as as IN cord-353298-vr5hnzp8 135 10 an an DT cord-353298-vr5hnzp8 135 11 oligodendrocyte oligodendrocyte NNP cord-353298-vr5hnzp8 135 12 ( ( -LRB- cord-353298-vr5hnzp8 135 13 04 04 CD cord-353298-vr5hnzp8 135 14 + + CC cord-353298-vr5hnzp8 135 15 GC+ GC+ NNP cord-353298-vr5hnzp8 135 16 GFAP- gfap- NN cord-353298-vr5hnzp8 135 17 ) ) -RRB- cord-353298-vr5hnzp8 135 18 , , , cord-353298-vr5hnzp8 135 19 a a DT cord-353298-vr5hnzp8 135 20 type type NN cord-353298-vr5hnzp8 135 21 2 2 CD cord-353298-vr5hnzp8 135 22 astrocyt¢ astrocyt¢ CD cord-353298-vr5hnzp8 135 23 ( ( -LRB- cord-353298-vr5hnzp8 135 24 04 04 CD cord-353298-vr5hnzp8 135 25 + + SYM cord-353298-vr5hnzp8 135 26 GFAP+ GFAP+ NNP cord-353298-vr5hnzp8 135 27 GC- GC- NNP cord-353298-vr5hnzp8 135 28 ) ) -RRB- cord-353298-vr5hnzp8 135 29 , , , cord-353298-vr5hnzp8 135 30 an an DT cord-353298-vr5hnzp8 135 31 O-2A O-2A NNP cord-353298-vr5hnzp8 135 32 progenitor progenitor NN cord-353298-vr5hnzp8 135 33 ( ( -LRB- cord-353298-vr5hnzp8 135 34 04 04 CD cord-353298-vr5hnzp8 135 35 + + SYM cord-353298-vr5hnzp8 135 36 G g NN cord-353298-vr5hnzp8 135 37 C c NN cord-353298-vr5hnzp8 135 38 -GFAP- -gfap- NN cord-353298-vr5hnzp8 135 39 ) ) -RRB- cord-353298-vr5hnzp8 135 40 , , , cord-353298-vr5hnzp8 135 41 a a DT cord-353298-vr5hnzp8 135 42 mixed mixed JJ cord-353298-vr5hnzp8 135 43 oligodendrocyte oligodendrocyte NNP cord-353298-vr5hnzp8 135 44 - - HYPH cord-353298-vr5hnzp8 135 45 astrocyte astrocyte JJ cord-353298-vr5hnzp8 135 46 phenotype phenotype NN cord-353298-vr5hnzp8 135 47 cell cell NN cord-353298-vr5hnzp8 135 48 ( ( -LRB- cord-353298-vr5hnzp8 135 49 04 04 CD cord-353298-vr5hnzp8 135 50 + + CC cord-353298-vr5hnzp8 135 51 GC+ GC+ NNP cord-353298-vr5hnzp8 135 52 GFAP+ GFAP+ NNP cord-353298-vr5hnzp8 135 53 ) ) -RRB- cord-353298-vr5hnzp8 135 54 , , , cord-353298-vr5hnzp8 135 55 or or CC cord-353298-vr5hnzp8 135 56 a a DT cord-353298-vr5hnzp8 135 57 type type NN cord-353298-vr5hnzp8 135 58 1 1 CD cord-353298-vr5hnzp8 135 59 astrocyte astrocyte NN cord-353298-vr5hnzp8 136 1 ( ( -LRB- cord-353298-vr5hnzp8 136 2 GFAP+ GFAP+ NNP cord-353298-vr5hnzp8 136 3 0 0 CD cord-353298-vr5hnzp8 136 4 4 4 CD cord-353298-vr5hnzp8 136 5 -GC- -gc- ADD cord-353298-vr5hnzp8 136 6 ) ) -RRB- cord-353298-vr5hnzp8 136 7 . . . cord-353298-vr5hnzp8 137 1 ( ( -LRB- cord-353298-vr5hnzp8 137 2 In in IN cord-353298-vr5hnzp8 137 3 this this DT cord-353298-vr5hnzp8 137 4 paper paper NN cord-353298-vr5hnzp8 137 5 , , , cord-353298-vr5hnzp8 137 6 the the DT cord-353298-vr5hnzp8 137 7 term term NN cord-353298-vr5hnzp8 137 8 " " `` cord-353298-vr5hnzp8 137 9 type type NN cord-353298-vr5hnzp8 137 10 2 2 CD cord-353298-vr5hnzp8 137 11 astrocyte astrocyte NN cord-353298-vr5hnzp8 137 12 " " '' cord-353298-vr5hnzp8 137 13 will will MD cord-353298-vr5hnzp8 137 14 be be VB cord-353298-vr5hnzp8 137 15 used use VBN cord-353298-vr5hnzp8 137 16 to to TO cord-353298-vr5hnzp8 137 17 denote denote VB cord-353298-vr5hnzp8 138 1 only only RB cord-353298-vr5hnzp8 138 2 the the DT cord-353298-vr5hnzp8 138 3 04 04 CD cord-353298-vr5hnzp8 138 4 + + CC cord-353298-vr5hnzp8 139 1 GFAP+ GFAP+ NNP cord-353298-vr5hnzp8 139 2 G G NNP cord-353298-vr5hnzp8 139 3 C c NN cord-353298-vr5hnzp8 139 4 -antigenic -antigenic NN cord-353298-vr5hnzp8 139 5 phenotype phenotype NN cord-353298-vr5hnzp8 139 6 and and CC cord-353298-vr5hnzp8 139 7 is be VBZ cord-353298-vr5hnzp8 139 8 not not RB cord-353298-vr5hnzp8 139 9 intended intend VBN cord-353298-vr5hnzp8 139 10 to to TO cord-353298-vr5hnzp8 139 11 indicate indicate VB cord-353298-vr5hnzp8 139 12 a a DT cord-353298-vr5hnzp8 139 13 specific specific JJ cord-353298-vr5hnzp8 139 14 localization localization NN cord-353298-vr5hnzp8 139 15 or or CC cord-353298-vr5hnzp8 139 16 function function NN cord-353298-vr5hnzp8 139 17 in in IN cord-353298-vr5hnzp8 139 18 vivo vivo NNP cord-353298-vr5hnzp8 139 19 . . . cord-353298-vr5hnzp8 139 20 ) ) -RRB- cord-353298-vr5hnzp8 140 1 Glial glial JJ cord-353298-vr5hnzp8 140 2 cells cell NNS cord-353298-vr5hnzp8 140 3 were be VBD cord-353298-vr5hnzp8 140 4 isolated isolate VBN cord-353298-vr5hnzp8 140 5 and and CC cord-353298-vr5hnzp8 140 6 cultured culture VBN cord-353298-vr5hnzp8 140 7 in in IN cord-353298-vr5hnzp8 140 8 parallel parallel NN cord-353298-vr5hnzp8 140 9 from from IN cord-353298-vr5hnzp8 140 10 spinal spinal JJ cord-353298-vr5hnzp8 140 11 cords cord NNS cord-353298-vr5hnzp8 140 12 of of IN cord-353298-vr5hnzp8 140 13 infected infected JJ cord-353298-vr5hnzp8 140 14 and and CC cord-353298-vr5hnzp8 140 15 age age NN cord-353298-vr5hnzp8 140 16 - - HYPH cord-353298-vr5hnzp8 140 17 matched match VBN cord-353298-vr5hnzp8 140 18 control control NN cord-353298-vr5hnzp8 140 19 mice mouse NNS cord-353298-vr5hnzp8 140 20 at at IN cord-353298-vr5hnzp8 140 21 several several JJ cord-353298-vr5hnzp8 140 22 intervals interval NNS cord-353298-vr5hnzp8 140 23 after after IN cord-353298-vr5hnzp8 140 24 viral viral JJ cord-353298-vr5hnzp8 140 25 inoculation inoculation NN cord-353298-vr5hnzp8 140 26 . . . cord-353298-vr5hnzp8 141 1 These these DT cord-353298-vr5hnzp8 141 2 cultures culture NNS cord-353298-vr5hnzp8 141 3 contained contain VBD cord-353298-vr5hnzp8 141 4 various various JJ cord-353298-vr5hnzp8 141 5 types type NNS cord-353298-vr5hnzp8 141 6 of of IN cord-353298-vr5hnzp8 141 7 glial glial JJ cord-353298-vr5hnzp8 141 8 cells cell NNS cord-353298-vr5hnzp8 141 9 , , , cord-353298-vr5hnzp8 141 10 of of IN cord-353298-vr5hnzp8 141 11 which which WDT cord-353298-vr5hnzp8 141 12 O-2A O-2A NNP cord-353298-vr5hnzp8 141 13 lineage lineage NN cord-353298-vr5hnzp8 141 14 cells cell NNS cord-353298-vr5hnzp8 141 15 ( ( -LRB- cord-353298-vr5hnzp8 141 16 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 141 17 , , , cord-353298-vr5hnzp8 141 18 O-2A O-2A NNP cord-353298-vr5hnzp8 141 19 progenitors progenitor NNS cord-353298-vr5hnzp8 141 20 , , , cord-353298-vr5hnzp8 141 21 type type NN cord-353298-vr5hnzp8 141 22 2 2 CD cord-353298-vr5hnzp8 141 23 astrocytes astrocyte NNS cord-353298-vr5hnzp8 141 24 , , , cord-353298-vr5hnzp8 141 25 and and CC cord-353298-vr5hnzp8 141 26 mixed mixed JJ cord-353298-vr5hnzp8 141 27 phenotype phenotype NN cord-353298-vr5hnzp8 141 28 cells cell NNS cord-353298-vr5hnzp8 141 29 ) ) -RRB- cord-353298-vr5hnzp8 141 30 represented represent VBD cord-353298-vr5hnzp8 141 31 a a DT cord-353298-vr5hnzp8 141 32 small small JJ cord-353298-vr5hnzp8 141 33 proportion proportion NN cord-353298-vr5hnzp8 141 34 of of IN cord-353298-vr5hnzp8 141 35 the the DT cord-353298-vr5hnzp8 141 36 total total NN cord-353298-vr5hnzp8 141 37 . . . cord-353298-vr5hnzp8 142 1 The the DT cord-353298-vr5hnzp8 142 2 number number NN cord-353298-vr5hnzp8 142 3 of of IN cord-353298-vr5hnzp8 142 4 O-2A O-2A NNP cord-353298-vr5hnzp8 142 5 lineage lineage NN cord-353298-vr5hnzp8 142 6 cells cell NNS cord-353298-vr5hnzp8 142 7 was be VBD cord-353298-vr5hnzp8 142 8 counted count VBN cord-353298-vr5hnzp8 142 9 after after IN cord-353298-vr5hnzp8 142 10 1 1 CD cord-353298-vr5hnzp8 142 11 d d NN cord-353298-vr5hnzp8 142 12 in in IN cord-353298-vr5hnzp8 142 13 culture culture NN cord-353298-vr5hnzp8 142 14 ( ( -LRB- cord-353298-vr5hnzp8 142 15 Fig Fig NNP cord-353298-vr5hnzp8 142 16 . . NNP cord-353298-vr5hnzp8 142 17 2 2 CD cord-353298-vr5hnzp8 142 18 ) ) -RRB- cord-353298-vr5hnzp8 142 19 . . . cord-353298-vr5hnzp8 143 1 This this DT cord-353298-vr5hnzp8 143 2 number number NN cord-353298-vr5hnzp8 143 3 was be VBD cord-353298-vr5hnzp8 143 4 similar similar JJ cord-353298-vr5hnzp8 143 5 for for IN cord-353298-vr5hnzp8 143 6 control control NN cord-353298-vr5hnzp8 143 7 and and CC cord-353298-vr5hnzp8 143 8 experimental experimental JJ cord-353298-vr5hnzp8 143 9 tissue tissue NN cord-353298-vr5hnzp8 143 10 at at IN cord-353298-vr5hnzp8 143 11 1 1 CD cord-353298-vr5hnzp8 143 12 wpi wpi NN cord-353298-vr5hnzp8 143 13 ( ( -LRB- cord-353298-vr5hnzp8 143 14 Fig Fig NNP cord-353298-vr5hnzp8 143 15 . . NNP cord-353298-vr5hnzp8 143 16 2 2 LS cord-353298-vr5hnzp8 143 17 ) ) -RRB- cord-353298-vr5hnzp8 143 18 when when WRB cord-353298-vr5hnzp8 143 19 demyelination demyelination NN cord-353298-vr5hnzp8 143 20 was be VBD cord-353298-vr5hnzp8 143 21 not not RB cord-353298-vr5hnzp8 143 22 yet yet RB cord-353298-vr5hnzp8 143 23 detected detect VBN cord-353298-vr5hnzp8 143 24 ( ( -LRB- cord-353298-vr5hnzp8 143 25 see see VB cord-353298-vr5hnzp8 143 26 Fig Fig NNP cord-353298-vr5hnzp8 143 27 . . . cord-353298-vr5hnzp8 144 1 3 3 LS cord-353298-vr5hnzp8 144 2 , , , cord-353298-vr5hnzp8 144 3 A a NN cord-353298-vr5hnzp8 144 4 and and CC cord-353298-vr5hnzp8 144 5 B b NN cord-353298-vr5hnzp8 144 6 ) ) -RRB- cord-353298-vr5hnzp8 144 7 . . . cord-353298-vr5hnzp8 145 1 As as IN cord-353298-vr5hnzp8 145 2 demyelination demyelination NN cord-353298-vr5hnzp8 145 3 and and CC cord-353298-vr5hnzp8 145 4 vacuolation vacuolation NN cord-353298-vr5hnzp8 145 5 progressed progress VBD cord-353298-vr5hnzp8 145 6 ( ( -LRB- cord-353298-vr5hnzp8 145 7 3 3 CD cord-353298-vr5hnzp8 145 8 - - SYM cord-353298-vr5hnzp8 145 9 5 5 CD cord-353298-vr5hnzp8 145 10 wpi wpi NN cord-353298-vr5hnzp8 145 11 , , , cord-353298-vr5hnzp8 145 12 see see VB cord-353298-vr5hnzp8 145 13 Fig Fig NNP cord-353298-vr5hnzp8 145 14 . . . cord-353298-vr5hnzp8 145 15 3 3 CD cord-353298-vr5hnzp8 145 16 C C NNP cord-353298-vr5hnzp8 145 17 ) ) -RRB- cord-353298-vr5hnzp8 145 18 , , , cord-353298-vr5hnzp8 145 19 O-2A O-2A NNP cord-353298-vr5hnzp8 145 20 lineage lineage NN cord-353298-vr5hnzp8 145 21 cells cell NNS cord-353298-vr5hnzp8 145 22 were be VBD cord-353298-vr5hnzp8 145 23 much much RB cord-353298-vr5hnzp8 145 24 more more RBR cord-353298-vr5hnzp8 145 25 abundant abundant JJ cord-353298-vr5hnzp8 145 26 in in IN cord-353298-vr5hnzp8 145 27 cultures culture NNS cord-353298-vr5hnzp8 145 28 of of IN cord-353298-vr5hnzp8 145 29 the the DT cord-353298-vr5hnzp8 145 30 demyelinated demyelinate VBN cord-353298-vr5hnzp8 145 31 tissue tissue NN cord-353298-vr5hnzp8 145 32 ( ( -LRB- cord-353298-vr5hnzp8 145 33 Fig Fig NNP cord-353298-vr5hnzp8 145 34 . . NNP cord-353298-vr5hnzp8 145 35 2 2 CD cord-353298-vr5hnzp8 145 36 ) ) -RRB- cord-353298-vr5hnzp8 145 37 . . . cord-353298-vr5hnzp8 146 1 With with IN cord-353298-vr5hnzp8 146 2 the the DT cord-353298-vr5hnzp8 146 3 onset onset NN cord-353298-vr5hnzp8 146 4 of of IN cord-353298-vr5hnzp8 146 5 remyelination remyelination NN cord-353298-vr5hnzp8 146 6 ( ( -LRB- cord-353298-vr5hnzp8 146 7 6 6 CD cord-353298-vr5hnzp8 146 8 - - SYM cord-353298-vr5hnzp8 146 9 8 8 CD cord-353298-vr5hnzp8 146 10 wpi wpi NN cord-353298-vr5hnzp8 146 11 , , , cord-353298-vr5hnzp8 146 12 see see VB cord-353298-vr5hnzp8 146 13 Fig Fig NNP cord-353298-vr5hnzp8 146 14 . . . cord-353298-vr5hnzp8 146 15 3 3 CD cord-353298-vr5hnzp8 146 16 D d NN cord-353298-vr5hnzp8 146 17 ) ) -RRB- cord-353298-vr5hnzp8 146 18 , , , cord-353298-vr5hnzp8 146 19 the the DT cord-353298-vr5hnzp8 146 20 number number NN cord-353298-vr5hnzp8 146 21 of of IN cord-353298-vr5hnzp8 146 22 O-2A O-2A NNP cord-353298-vr5hnzp8 146 23 lineage lineage NN cord-353298-vr5hnzp8 146 24 cells cell NNS cord-353298-vr5hnzp8 146 25 derived derive VBN cord-353298-vr5hnzp8 146 26 from from IN cord-353298-vr5hnzp8 146 27 lesioned lesioned JJ cord-353298-vr5hnzp8 146 28 tissue tissue NN cord-353298-vr5hnzp8 146 29 declined decline VBD cord-353298-vr5hnzp8 146 30 ( ( -LRB- cord-353298-vr5hnzp8 146 31 Fig Fig NNP cord-353298-vr5hnzp8 146 32 . . NNP cord-353298-vr5hnzp8 146 33 2 2 CD cord-353298-vr5hnzp8 146 34 ) ) -RRB- cord-353298-vr5hnzp8 146 35 . . . cord-353298-vr5hnzp8 147 1 It -PRON- PRP cord-353298-vr5hnzp8 147 2 is be VBZ cord-353298-vr5hnzp8 147 3 possible possible JJ cord-353298-vr5hnzp8 147 4 that that IN cord-353298-vr5hnzp8 147 5 CNS CNS NNP cord-353298-vr5hnzp8 147 6 inflammation inflammation NN cord-353298-vr5hnzp8 147 7 and and CC cord-353298-vr5hnzp8 147 8 vacuolation vacuolation NN cord-353298-vr5hnzp8 147 9 may may MD cord-353298-vr5hnzp8 147 10 have have VB cord-353298-vr5hnzp8 147 11 facilitated facilitate VBN cord-353298-vr5hnzp8 147 12 dissociation dissociation NN cord-353298-vr5hnzp8 147 13 of of IN cord-353298-vr5hnzp8 147 14 the the DT cord-353298-vr5hnzp8 147 15 demyelinated demyelinate VBN cord-353298-vr5hnzp8 147 16 tissue tissue NN cord-353298-vr5hnzp8 147 17 and and CC cord-353298-vr5hnzp8 147 18 thereby thereby RB cord-353298-vr5hnzp8 147 19 improved improve VBN cord-353298-vr5hnzp8 147 20 the the DT cord-353298-vr5hnzp8 147 21 yield yield NN cord-353298-vr5hnzp8 147 22 of of IN cord-353298-vr5hnzp8 147 23 growing grow VBG cord-353298-vr5hnzp8 147 24 c¢11s c¢11s NN cord-353298-vr5hnzp8 147 25 . . . cord-353298-vr5hnzp8 148 1 Yet yet CC cord-353298-vr5hnzp8 148 2 the the DT cord-353298-vr5hnzp8 148 3 cultures culture NNS cord-353298-vr5hnzp8 148 4 from from IN cord-353298-vr5hnzp8 148 5 control control NN cord-353298-vr5hnzp8 148 6 versus versus IN cord-353298-vr5hnzp8 148 7 demyelinated demyelinated JJ cord-353298-vr5hnzp8 148 8 CNS CNS NNP cord-353298-vr5hnzp8 148 9 differed differ VBD cord-353298-vr5hnzp8 148 10 not not RB cord-353298-vr5hnzp8 148 11 only only RB cord-353298-vr5hnzp8 148 12 in in IN cord-353298-vr5hnzp8 148 13 cell cell NN cord-353298-vr5hnzp8 149 1 The the DT cord-353298-vr5hnzp8 149 2 other other JJ cord-353298-vr5hnzp8 149 3 cell cell NN cord-353298-vr5hnzp8 149 4 types type NNS cord-353298-vr5hnzp8 149 5 in in IN cord-353298-vr5hnzp8 149 6 our -PRON- PRP$ cord-353298-vr5hnzp8 149 7 cultures culture NNS cord-353298-vr5hnzp8 149 8 were be VBD cord-353298-vr5hnzp8 149 9 type type NN cord-353298-vr5hnzp8 149 10 1 1 CD cord-353298-vr5hnzp8 149 11 astrocytes astrocyte NNS cord-353298-vr5hnzp8 149 12 , , , cord-353298-vr5hnzp8 149 13 fibroblasts fibroblast NNS cord-353298-vr5hnzp8 149 14 , , , cord-353298-vr5hnzp8 149 15 and and CC cord-353298-vr5hnzp8 149 16 microglia microglia NN cord-353298-vr5hnzp8 149 17 . . . cord-353298-vr5hnzp8 150 1 Flat flat JJ cord-353298-vr5hnzp8 150 2 calls call NNS cord-353298-vr5hnzp8 150 3 expressing express VBG cord-353298-vr5hnzp8 150 4 GFAP GFAP NNP cord-353298-vr5hnzp8 150 5 but but CC cord-353298-vr5hnzp8 151 1 not not RB cord-353298-vr5hnzp8 151 2 04 04 CD cord-353298-vr5hnzp8 151 3 antigens antigen NNS cord-353298-vr5hnzp8 151 4 were be VBD cord-353298-vr5hnzp8 151 5 identified identify VBN cord-353298-vr5hnzp8 151 6 as as IN cord-353298-vr5hnzp8 151 7 type type NN cord-353298-vr5hnzp8 151 8 1 1 CD cord-353298-vr5hnzp8 151 9 astrocytes astrocyte NNS cord-353298-vr5hnzp8 151 10 . . . cord-353298-vr5hnzp8 152 1 Type type NN cord-353298-vr5hnzp8 152 2 1 1 CD cord-353298-vr5hnzp8 152 3 astrocytes astrocyte NNS cord-353298-vr5hnzp8 152 4 seemed seem VBD cord-353298-vr5hnzp8 152 5 to to TO cord-353298-vr5hnzp8 152 6 be be VB cord-353298-vr5hnzp8 152 7 more more RBR cord-353298-vr5hnzp8 152 8 prevalent prevalent JJ cord-353298-vr5hnzp8 152 9 in in IN cord-353298-vr5hnzp8 152 10 cultures culture NNS cord-353298-vr5hnzp8 152 11 of of IN cord-353298-vr5hnzp8 152 12 lesioned lesione VBN cord-353298-vr5hnzp8 152 13 tissue tissue NN cord-353298-vr5hnzp8 152 14 . . . cord-353298-vr5hnzp8 153 1 However however RB cord-353298-vr5hnzp8 153 2 , , , cord-353298-vr5hnzp8 153 3 at at IN cord-353298-vr5hnzp8 153 4 1 1 CD cord-353298-vr5hnzp8 153 5 div div NN cord-353298-vr5hnzp8 153 6 such such JJ cord-353298-vr5hnzp8 153 7 cells cell NNS cord-353298-vr5hnzp8 153 8 were be VBD cord-353298-vr5hnzp8 153 9 usually usually RB cord-353298-vr5hnzp8 153 10 found find VBN cord-353298-vr5hnzp8 153 11 in in IN cord-353298-vr5hnzp8 153 12 dense dense JJ cord-353298-vr5hnzp8 153 13 clusters cluster NNS cord-353298-vr5hnzp8 153 14 that that WDT cord-353298-vr5hnzp8 153 15 prohibited prohibit VBD cord-353298-vr5hnzp8 153 16 accurate accurate JJ cord-353298-vr5hnzp8 153 17 quantitation quantitation NN cord-353298-vr5hnzp8 153 18 of of IN cord-353298-vr5hnzp8 153 19 the the DT cord-353298-vr5hnzp8 153 20 initial initial JJ cord-353298-vr5hnzp8 153 21 type type NN cord-353298-vr5hnzp8 153 22 1,astrocyte 1,astrocyte CD cord-353298-vr5hnzp8 153 23 population population NN cord-353298-vr5hnzp8 153 24 ( ( -LRB- cord-353298-vr5hnzp8 153 25 Fig Fig NNP cord-353298-vr5hnzp8 153 26 . . NNP cord-353298-vr5hnzp8 153 27 4 4 CD cord-353298-vr5hnzp8 153 28 , , , cord-353298-vr5hnzp8 153 29 A a NN cord-353298-vr5hnzp8 153 30 and and CC cord-353298-vr5hnzp8 153 31 C C NNP cord-353298-vr5hnzp8 153 32 ) ) -RRB- cord-353298-vr5hnzp8 153 33 . . . cord-353298-vr5hnzp8 154 1 By by IN cord-353298-vr5hnzp8 154 2 3 3 CD cord-353298-vr5hnzp8 154 3 and and CC cord-353298-vr5hnzp8 154 4 6div 6div CD cord-353298-vr5hnzp8 154 5 , , , cord-353298-vr5hnzp8 154 6 type type NN cord-353298-vr5hnzp8 154 7 1 1 CD cord-353298-vr5hnzp8 154 8 astrocytes astrocyte NNS cord-353298-vr5hnzp8 154 9 grew grow VBD cord-353298-vr5hnzp8 154 10 out out RP cord-353298-vr5hnzp8 154 11 from from IN cord-353298-vr5hnzp8 154 12 these these DT cord-353298-vr5hnzp8 154 13 clusters cluster NNS cord-353298-vr5hnzp8 154 14 and and CC cord-353298-vr5hnzp8 154 15 proliferated proliferate VBD cord-353298-vr5hnzp8 154 16 , , , cord-353298-vr5hnzp8 154 17 as as IN cord-353298-vr5hnzp8 154 18 assayed assay VBN cord-353298-vr5hnzp8 154 19 by by IN cord-353298-vr5hnzp8 154 20 [ [ -LRB- cord-353298-vr5hnzp8 154 21 3H]thymidine 3h]thymidine CD cord-353298-vr5hnzp8 154 22 incorporation incorporation NN cord-353298-vr5hnzp8 154 23 ( ( -LRB- cord-353298-vr5hnzp8 154 24 Fig Fig NNP cord-353298-vr5hnzp8 154 25 . . NNP cord-353298-vr5hnzp8 154 26 4 4 CD cord-353298-vr5hnzp8 154 27 , , , cord-353298-vr5hnzp8 154 28 B b NN cord-353298-vr5hnzp8 154 29 and and CC cord-353298-vr5hnzp8 154 30 D D NNP cord-353298-vr5hnzp8 154 31 ) ) -RRB- cord-353298-vr5hnzp8 154 32 . . . cord-353298-vr5hnzp8 155 1 Flat flat JJ cord-353298-vr5hnzp8 155 2 cells cell NNS cord-353298-vr5hnzp8 155 3 presumed presume VBN cord-353298-vr5hnzp8 155 4 to to TO cord-353298-vr5hnzp8 155 5 be be VB cord-353298-vr5hnzp8 155 6 fibroblasts fibroblast NNS cord-353298-vr5hnzp8 155 7 , , , cord-353298-vr5hnzp8 155 8 due due IN cord-353298-vr5hnzp8 155 9 to to IN cord-353298-vr5hnzp8 155 10 the the DT cord-353298-vr5hnzp8 155 11 absence absence NN cord-353298-vr5hnzp8 155 12 of of IN cord-353298-vr5hnzp8 155 13 04 04 CD cord-353298-vr5hnzp8 155 14 , , , cord-353298-vr5hnzp8 155 15 GC GC NNP cord-353298-vr5hnzp8 155 16 , , , cord-353298-vr5hnzp8 155 17 or or CC cord-353298-vr5hnzp8 155 18 GFAP GFAP NNP cord-353298-vr5hnzp8 155 19 immunostaining immunostaining NN cord-353298-vr5hnzp8 155 20 , , , cord-353298-vr5hnzp8 155 21 were be VBD cord-353298-vr5hnzp8 155 22 present present JJ cord-353298-vr5hnzp8 155 23 and and CC cord-353298-vr5hnzp8 155 24 p p NN cord-353298-vr5hnzp8 155 25 ~ ~ CD cord-353298-vr5hnzp8 155 26 liferated liferate VBN cord-353298-vr5hnzp8 155 27 in in IN cord-353298-vr5hnzp8 155 28 all all DT cord-353298-vr5hnzp8 155 29 cultures culture NNS cord-353298-vr5hnzp8 155 30 examined examine VBN cord-353298-vr5hnzp8 155 31 ( ( -LRB- cord-353298-vr5hnzp8 155 32 not not RB cord-353298-vr5hnzp8 155 33 shown show VBN cord-353298-vr5hnzp8 155 34 ) ) -RRB- cord-353298-vr5hnzp8 155 35 . . . cord-353298-vr5hnzp8 156 1 Microglia Microglia NNP cord-353298-vr5hnzp8 156 2 and/or and/or CC cord-353298-vr5hnzp8 156 3 macrophages macrophage NNS cord-353298-vr5hnzp8 156 4 were be VBD cord-353298-vr5hnzp8 156 5 identified identify VBN cord-353298-vr5hnzp8 156 6 by by IN cord-353298-vr5hnzp8 156 7 their -PRON- PRP$ cord-353298-vr5hnzp8 156 8 ameboid ameboid JJ cord-353298-vr5hnzp8 156 9 appearance appearance NN cord-353298-vr5hnzp8 156 10 , , , cord-353298-vr5hnzp8 156 11 the the DT cord-353298-vr5hnzp8 156 12 presence presence NN cord-353298-vr5hnzp8 156 13 of of IN cord-353298-vr5hnzp8 156 14 phagocytic phagocytic JJ cord-353298-vr5hnzp8 156 15 debris debris NN cord-353298-vr5hnzp8 156 16 within within IN cord-353298-vr5hnzp8 156 17 the the DT cord-353298-vr5hnzp8 156 18 cells cell NNS cord-353298-vr5hnzp8 156 19 , , , cord-353298-vr5hnzp8 156 20 and and CC cord-353298-vr5hnzp8 156 21 the the DT cord-353298-vr5hnzp8 156 22 absence absence NN cord-353298-vr5hnzp8 156 23 of of IN cord-353298-vr5hnzp8 156 24 04 04 CD cord-353298-vr5hnzp8 156 25 immunostaining immunostaine VBG cord-353298-vr5hnzp8 156 26 ( ( -LRB- cord-353298-vr5hnzp8 156 27 Giulian Giulian NNP cord-353298-vr5hnzp8 156 28 , , , cord-353298-vr5hnzp8 156 29 1987 1987 CD cord-353298-vr5hnzp8 156 30 ; ; : cord-353298-vr5hnzp8 156 31 Rieske Rieske NNP cord-353298-vr5hnzp8 156 32 et et NNP cord-353298-vr5hnzp8 156 33 al al NNP cord-353298-vr5hnzp8 156 34 . . NNP cord-353298-vr5hnzp8 156 35 , , , cord-353298-vr5hnzp8 156 36 1989 1989 CD cord-353298-vr5hnzp8 156 37 ) ) -RRB- cord-353298-vr5hnzp8 156 38 . . . cord-353298-vr5hnzp8 157 1 Microglial Microglial NNP cord-353298-vr5hnzp8 157 2 ceils ceil NNS cord-353298-vr5hnzp8 157 3 are be VBP cord-353298-vr5hnzp8 157 4 the the DT cord-353298-vr5hnzp8 157 5 resident resident JJ cord-353298-vr5hnzp8 157 6 macrophages macrophage NNS cord-353298-vr5hnzp8 157 7 of of IN cord-353298-vr5hnzp8 157 8 the the DT cord-353298-vr5hnzp8 157 9 CNS CNS NNP cord-353298-vr5hnzp8 157 10 and and CC cord-353298-vr5hnzp8 157 11 markers marker NNS cord-353298-vr5hnzp8 157 12 for for IN cord-353298-vr5hnzp8 157 13 distinguishing distinguish VBG cord-353298-vr5hnzp8 157 14 mi mi NNP cord-353298-vr5hnzp8 157 15 - - HYPH cord-353298-vr5hnzp8 157 16 croglia croglia NNP cord-353298-vr5hnzp8 157 17 from from IN cord-353298-vr5hnzp8 157 18 blood blood NN cord-353298-vr5hnzp8 157 19 - - HYPH cord-353298-vr5hnzp8 157 20 born bear VBN cord-353298-vr5hnzp8 157 21 macrophages macrophage NNS cord-353298-vr5hnzp8 157 22 , , , cord-353298-vr5hnzp8 157 23 which which WDT cord-353298-vr5hnzp8 157 24 can can MD cord-353298-vr5hnzp8 157 25 infiltrate infiltrate VB cord-353298-vr5hnzp8 157 26 the the DT cord-353298-vr5hnzp8 157 27 CNS CNS NNP cord-353298-vr5hnzp8 157 28 , , , cord-353298-vr5hnzp8 157 29 are be VBP cord-353298-vr5hnzp8 157 30 not not RB cord-353298-vr5hnzp8 157 31 presently presently RB cord-353298-vr5hnzp8 157 32 available available JJ cord-353298-vr5hnzp8 157 33 . . . cord-353298-vr5hnzp8 158 1 For for IN cord-353298-vr5hnzp8 158 2 simplicity simplicity NN cord-353298-vr5hnzp8 158 3 , , , cord-353298-vr5hnzp8 158 4 cells cell NNS cord-353298-vr5hnzp8 158 5 with with IN cord-353298-vr5hnzp8 158 6 the the DT cord-353298-vr5hnzp8 158 7 phenotype phenotype NN cord-353298-vr5hnzp8 158 8 of of IN cord-353298-vr5hnzp8 158 9 microglia microglia NNS cord-353298-vr5hnzp8 158 10 and/or and/or CC cord-353298-vr5hnzp8 158 11 macrophages macrophage NNS cord-353298-vr5hnzp8 158 12 will will MD cord-353298-vr5hnzp8 158 13 be be VB cord-353298-vr5hnzp8 158 14 referred refer VBN cord-353298-vr5hnzp8 158 15 to to IN cord-353298-vr5hnzp8 158 16 as as RB cord-353298-vr5hnzp8 158 17 microglia microglia NN cord-353298-vr5hnzp8 158 18 throughout throughout IN cord-353298-vr5hnzp8 158 19 this this DT cord-353298-vr5hnzp8 158 20 paper paper NN cord-353298-vr5hnzp8 158 21 . . . cord-353298-vr5hnzp8 159 1 These these DT cord-353298-vr5hnzp8 159 2 cells cell NNS cord-353298-vr5hnzp8 159 3 were be VBD cord-353298-vr5hnzp8 159 4 rare rare JJ cord-353298-vr5hnzp8 159 5 in in IN cord-353298-vr5hnzp8 159 6 cultures culture NNS cord-353298-vr5hnzp8 159 7 of of IN cord-353298-vr5hnzp8 159 8 control control NN cord-353298-vr5hnzp8 159 9 tissue tissue NN cord-353298-vr5hnzp8 159 10 . . . cord-353298-vr5hnzp8 160 1 In in IN cord-353298-vr5hnzp8 160 2 contrast contrast NN cord-353298-vr5hnzp8 160 3 , , , cord-353298-vr5hnzp8 160 4 the the DT cord-353298-vr5hnzp8 160 5 number number NN cord-353298-vr5hnzp8 160 6 of of IN cord-353298-vr5hnzp8 160 7 microglia microglia NNS cord-353298-vr5hnzp8 160 8 cultured culture VBN cord-353298-vr5hnzp8 160 9 from from IN cord-353298-vr5hnzp8 160 10 diseased diseased JJ cord-353298-vr5hnzp8 160 11 tissue tissue NN cord-353298-vr5hnzp8 160 12 increased increase VBD cord-353298-vr5hnzp8 160 13 dramatically dramatically RB cord-353298-vr5hnzp8 160 14 during during IN cord-353298-vr5hnzp8 160 15 the the DT cord-353298-vr5hnzp8 160 16 period period NN cord-353298-vr5hnzp8 160 17 of of IN cord-353298-vr5hnzp8 160 18 demyelination demyelination NN cord-353298-vr5hnzp8 160 19 ( ( -LRB- cord-353298-vr5hnzp8 160 20 3 3 CD cord-353298-vr5hnzp8 160 21 - - SYM cord-353298-vr5hnzp8 160 22 5 5 CD cord-353298-vr5hnzp8 160 23 wpi wpi NN cord-353298-vr5hnzp8 160 24 ) ) -RRB- cord-353298-vr5hnzp8 160 25 . . . cord-353298-vr5hnzp8 161 1 We -PRON- PRP cord-353298-vr5hnzp8 161 2 identified identify VBD cord-353298-vr5hnzp8 161 3 Schwann Schwann NNP cord-353298-vr5hnzp8 161 4 cells cell NNS cord-353298-vr5hnzp8 161 5 with with IN cord-353298-vr5hnzp8 161 6 an an DT cord-353298-vr5hnzp8 161 7 antibody antibody NN cord-353298-vr5hnzp8 161 8 to to IN cord-353298-vr5hnzp8 161 9 the the DT cord-353298-vr5hnzp8 161 10 receptor receptor NN cord-353298-vr5hnzp8 161 11 for for IN cord-353298-vr5hnzp8 161 12 nerve nerve NN cord-353298-vr5hnzp8 161 13 growth growth NN cord-353298-vr5hnzp8 161 14 factor factor NN cord-353298-vr5hnzp8 162 1 ( ( -LRB- cord-353298-vr5hnzp8 162 2 Chandler Chandler NNP cord-353298-vr5hnzp8 162 3 et et NNP cord-353298-vr5hnzp8 162 4 al al NNP cord-353298-vr5hnzp8 162 5 . . NNP cord-353298-vr5hnzp8 162 6 , , , cord-353298-vr5hnzp8 162 7 1984 1984 CD cord-353298-vr5hnzp8 162 8 ) ) -RRB- cord-353298-vr5hnzp8 162 9 that that WDT cord-353298-vr5hnzp8 162 10 labeled label VBD cord-353298-vr5hnzp8 162 11 Schwann Schwann NNP cord-353298-vr5hnzp8 162 12 cells cell NNS cord-353298-vr5hnzp8 162 13 cultured culture VBN cord-353298-vr5hnzp8 162 14 from from IN cord-353298-vr5hnzp8 162 15 rat rat NN cord-353298-vr5hnzp8 162 16 sciatic sciatic NN cord-353298-vr5hnzp8 162 17 nerve nerve NN cord-353298-vr5hnzp8 162 18 , , , cord-353298-vr5hnzp8 162 19 which which WDT cord-353298-vr5hnzp8 162 20 have have VBP cord-353298-vr5hnzp8 162 21 been be VBN cord-353298-vr5hnzp8 162 22 shown show VBN cord-353298-vr5hnzp8 162 23 to to TO cord-353298-vr5hnzp8 162 24 express express VB cord-353298-vr5hnzp8 162 25 this this DT cord-353298-vr5hnzp8 162 26 receptor receptor NN cord-353298-vr5hnzp8 162 27 ( ( -LRB- cord-353298-vr5hnzp8 162 28 Yasuda Yasuda NNP cord-353298-vr5hnzp8 162 29 et et NNP cord-353298-vr5hnzp8 162 30 al al NNP cord-353298-vr5hnzp8 162 31 . . NNP cord-353298-vr5hnzp8 162 32 , , , cord-353298-vr5hnzp8 162 33 1987 1987 CD cord-353298-vr5hnzp8 162 34 ; ; : cord-353298-vr5hnzp8 162 35 DiStefano DiStefano NNP cord-353298-vr5hnzp8 162 36 and and CC cord-353298-vr5hnzp8 162 37 Johnson Johnson NNP cord-353298-vr5hnzp8 162 38 , , , cord-353298-vr5hnzp8 162 39 1988 1988 CD cord-353298-vr5hnzp8 162 40 ) ) -RRB- cord-353298-vr5hnzp8 162 41 . . . cord-353298-vr5hnzp8 163 1 These these DT cord-353298-vr5hnzp8 163 2 cells cell NNS cord-353298-vr5hnzp8 163 3 were be VBD cord-353298-vr5hnzp8 163 4 not not RB cord-353298-vr5hnzp8 163 5 detected detect VBN cord-353298-vr5hnzp8 163 6 in in IN cord-353298-vr5hnzp8 163 7 cultures culture NNS cord-353298-vr5hnzp8 163 8 of of IN cord-353298-vr5hnzp8 163 9 control control NN cord-353298-vr5hnzp8 163 10 or or CC cord-353298-vr5hnzp8 163 11 infected infected JJ cord-353298-vr5hnzp8 163 12 spinal spinal JJ cord-353298-vr5hnzp8 163 13 cords cord NNS cord-353298-vr5hnzp8 163 14 ( ( -LRB- cord-353298-vr5hnzp8 163 15 1 1 CD cord-353298-vr5hnzp8 163 16 and and CC cord-353298-vr5hnzp8 163 17 4 4 CD cord-353298-vr5hnzp8 163 18 wpi wpi NNP cord-353298-vr5hnzp8 163 19 ) ) -RRB- cord-353298-vr5hnzp8 163 20 . . . cord-353298-vr5hnzp8 164 1 Similarly similarly RB cord-353298-vr5hnzp8 164 2 , , , cord-353298-vr5hnzp8 164 3 Schwarm Schwarm NNP cord-353298-vr5hnzp8 164 4 cells cell NNS cord-353298-vr5hnzp8 164 5 were be VBD cord-353298-vr5hnzp8 164 6 rarely rarely RB cord-353298-vr5hnzp8 164 7 observed observe VBN cord-353298-vr5hnzp8 164 8 in in IN cord-353298-vr5hnzp8 164 9 the the DT cord-353298-vr5hnzp8 164 10 remyelinating remyelinate VBG cord-353298-vr5hnzp8 164 11 lesions lesion NNS cord-353298-vr5hnzp8 164 12 ( ( -LRB- cord-353298-vr5hnzp8 164 13 Fig Fig NNP cord-353298-vr5hnzp8 164 14 . . . cord-353298-vr5hnzp8 164 15 3 3 CD cord-353298-vr5hnzp8 164 16 ) ) -RRB- cord-353298-vr5hnzp8 164 17 . . . cord-353298-vr5hnzp8 165 1 We -PRON- PRP cord-353298-vr5hnzp8 165 2 then then RB cord-353298-vr5hnzp8 165 3 examined examine VBD cord-353298-vr5hnzp8 165 4 the the DT cord-353298-vr5hnzp8 165 5 relative relative JJ cord-353298-vr5hnzp8 165 6 abundances abundance NNS cord-353298-vr5hnzp8 165 7 of of IN cord-353298-vr5hnzp8 165 8 the the DT cord-353298-vr5hnzp8 165 9 different different JJ cord-353298-vr5hnzp8 165 10 5 5 CD cord-353298-vr5hnzp8 165 11 and and CC cord-353298-vr5hnzp8 165 12 7 7 CD cord-353298-vr5hnzp8 165 13 ) ) -RRB- cord-353298-vr5hnzp8 165 14 . . . cord-353298-vr5hnzp8 166 1 The the DT cord-353298-vr5hnzp8 166 2 relative relative JJ cord-353298-vr5hnzp8 166 3 proportion proportion NN cord-353298-vr5hnzp8 166 4 of of IN cord-353298-vr5hnzp8 166 5 type type NN cord-353298-vr5hnzp8 166 6 2 2 CD cord-353298-vr5hnzp8 166 7 astrocytes astrocyte NNS cord-353298-vr5hnzp8 166 8 ( ( -LRB- cord-353298-vr5hnzp8 166 9 04 04 CD cord-353298-vr5hnzp8 166 10 + + SYM cord-353298-vr5hnzp8 166 11 GFAP+ gfap+ NN cord-353298-vr5hnzp8 166 12 G g NN cord-353298-vr5hnzp8 166 13 C c NN cord-353298-vr5hnzp8 166 14 - - , cord-353298-vr5hnzp8 166 15 ) ) -RRB- cord-353298-vr5hnzp8 166 16 increased increase VBD cord-353298-vr5hnzp8 166 17 between between IN cord-353298-vr5hnzp8 166 18 1 1 CD cord-353298-vr5hnzp8 166 19 and and CC cord-353298-vr5hnzp8 166 20 3 3 CD cord-353298-vr5hnzp8 166 21 div div NN cord-353298-vr5hnzp8 166 22 , , , cord-353298-vr5hnzp8 166 23 even even RB cord-353298-vr5hnzp8 166 24 though though IN cord-353298-vr5hnzp8 166 25 the the DT cord-353298-vr5hnzp8 166 26 cultures culture NNS cord-353298-vr5hnzp8 166 27 were be VBD cord-353298-vr5hnzp8 166 28 maintained maintain VBN cord-353298-vr5hnzp8 166 29 in in IN cord-353298-vr5hnzp8 166 30 defined define VBN cord-353298-vr5hnzp8 166 31 medium medium NN cord-353298-vr5hnzp8 166 32 with with IN cord-353298-vr5hnzp8 166 33 only only RB cord-353298-vr5hnzp8 166 34 0.5 0.5 CD cord-353298-vr5hnzp8 166 35 % % NN cord-353298-vr5hnzp8 166 36 FBS FBS NNP cord-353298-vr5hnzp8 166 37 ( ( -LRB- cord-353298-vr5hnzp8 166 38 Figs fig NNS cord-353298-vr5hnzp8 166 39 . . . cord-353298-vr5hnzp8 166 40 5 5 CD cord-353298-vr5hnzp8 166 41 and and CC cord-353298-vr5hnzp8 166 42 7 7 CD cord-353298-vr5hnzp8 166 43 ) ) -RRB- cord-353298-vr5hnzp8 166 44 . . . cord-353298-vr5hnzp8 167 1 Interestingly interestingly RB cord-353298-vr5hnzp8 167 2 , , , cord-353298-vr5hnzp8 167 3 in in IN cord-353298-vr5hnzp8 167 4 cultures culture NNS cord-353298-vr5hnzp8 167 5 of of IN cord-353298-vr5hnzp8 167 6 neonatal neonatal JJ cord-353298-vr5hnzp8 167 7 rat rat NN cord-353298-vr5hnzp8 167 8 optic optic JJ cord-353298-vr5hnzp8 167 9 nerve nerve NN cord-353298-vr5hnzp8 167 10 , , , cord-353298-vr5hnzp8 167 11 10 10 CD cord-353298-vr5hnzp8 167 12 % % NN cord-353298-vr5hnzp8 167 13 FBS FBS NNP cord-353298-vr5hnzp8 167 14 is be VBZ cord-353298-vr5hnzp8 167 15 required require VBN cord-353298-vr5hnzp8 167 16 to to TO cord-353298-vr5hnzp8 167 17 induce induce VB cord-353298-vr5hnzp8 167 18 development development NN cord-353298-vr5hnzp8 167 19 of of IN cord-353298-vr5hnzp8 167 20 a a DT cord-353298-vr5hnzp8 167 21 substantial substantial JJ cord-353298-vr5hnzp8 167 22 number number NN cord-353298-vr5hnzp8 167 23 of of IN cord-353298-vr5hnzp8 167 24 type type NN cord-353298-vr5hnzp8 167 25 2 2 CD cord-353298-vr5hnzp8 167 26 astrocyteg astrocyteg NNP cord-353298-vr5hnzp8 167 27 ( ( -LRB- cord-353298-vr5hnzp8 167 28 Raft Raft NNP cord-353298-vr5hnzp8 167 29 et et NNP cord-353298-vr5hnzp8 167 30 al al NNP cord-353298-vr5hnzp8 167 31 . . NNP cord-353298-vr5hnzp8 167 32 , , , cord-353298-vr5hnzp8 167 33 1983 1983 CD cord-353298-vr5hnzp8 167 34 ) ) -RRB- cord-353298-vr5hnzp8 167 35 . . . cord-353298-vr5hnzp8 168 1 In in IN cord-353298-vr5hnzp8 168 2 cultures culture NNS cord-353298-vr5hnzp8 168 3 of of IN cord-353298-vr5hnzp8 168 4 demyel demyel NNP cord-353298-vr5hnzp8 168 5 ~ ~ NFP cord-353298-vr5hnzp8 168 6 ated ate VBN cord-353298-vr5hnzp8 168 7 spinal spinal JJ cord-353298-vr5hnzp8 168 8 cord cord NN cord-353298-vr5hnzp8 168 9 tissue tissue NN cord-353298-vr5hnzp8 168 10 ( ( -LRB- cord-353298-vr5hnzp8 168 11 5 5 CD cord-353298-vr5hnzp8 168 12 wpi wpi NN cord-353298-vr5hnzp8 168 13 ) ) -RRB- cord-353298-vr5hnzp8 168 14 , , , cord-353298-vr5hnzp8 168 15 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 168 16 were be VBD cord-353298-vr5hnzp8 168 17 the the DT cord-353298-vr5hnzp8 168 18 predominant predominant JJ cord-353298-vr5hnzp8 168 19 cell cell NN cord-353298-vr5hnzp8 168 20 type type NN cord-353298-vr5hnzp8 168 21 after after IN cord-353298-vr5hnzp8 168 22 1 1 CD cord-353298-vr5hnzp8 168 23 div div NN cord-353298-vr5hnzp8 168 24 ( ( -LRB- cord-353298-vr5hnzp8 168 25 Fig Fig NNP cord-353298-vr5hnzp8 168 26 . . . cord-353298-vr5hnzp8 168 27 5 5 CD cord-353298-vr5hnzp8 168 28 ) ) -RRB- cord-353298-vr5hnzp8 168 29 . . . cord-353298-vr5hnzp8 169 1 However however RB cord-353298-vr5hnzp8 169 2 , , , cord-353298-vr5hnzp8 169 3 a a DT cord-353298-vr5hnzp8 169 4 larger large JJR cord-353298-vr5hnzp8 169 5 percentage percentage NN cord-353298-vr5hnzp8 169 6 of of IN cord-353298-vr5hnzp8 169 7 the the DT cord-353298-vr5hnzp8 169 8 O-2A O-2A NNP cord-353298-vr5hnzp8 169 9 population population NN cord-353298-vr5hnzp8 169 10 was be VBD cord-353298-vr5hnzp8 169 11 composed compose VBN cord-353298-vr5hnzp8 169 12 of of IN cord-353298-vr5hnzp8 169 13 type type NN cord-353298-vr5hnzp8 169 14 2 2 CD cord-353298-vr5hnzp8 169 15 astroeytes astroeyte NNS cord-353298-vr5hnzp8 169 16 in in IN cord-353298-vr5hnzp8 169 17 these these DT cord-353298-vr5hnzp8 169 18 cultures culture NNS cord-353298-vr5hnzp8 169 19 as as IN cord-353298-vr5hnzp8 169 20 compared compare VBN cord-353298-vr5hnzp8 169 21 with with IN cord-353298-vr5hnzp8 169 22 cultures culture NNS cord-353298-vr5hnzp8 169 23 of of IN cord-353298-vr5hnzp8 169 24 control control NN cord-353298-vr5hnzp8 169 25 tissue tissue NN cord-353298-vr5hnzp8 169 26 . . . cord-353298-vr5hnzp8 170 1 By by IN cord-353298-vr5hnzp8 170 2 3 3 CD cord-353298-vr5hnzp8 170 3 div div NN cord-353298-vr5hnzp8 170 4 , , , cord-353298-vr5hnzp8 170 5 type type NN cord-353298-vr5hnzp8 170 6 2 2 CD cord-353298-vr5hnzp8 170 7 astrocytes astrocyte NNS cord-353298-vr5hnzp8 170 8 became become VBD cord-353298-vr5hnzp8 170 9 even even RB cord-353298-vr5hnzp8 170 10 more more RBR cord-353298-vr5hnzp8 170 11 prevalent prevalent JJ cord-353298-vr5hnzp8 170 12 than than IN cord-353298-vr5hnzp8 170 13 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 170 14 . . . cord-353298-vr5hnzp8 171 1 At at IN cord-353298-vr5hnzp8 171 2 each each DT cord-353298-vr5hnzp8 171 3 time time NN cord-353298-vr5hnzp8 171 4 point point NN cord-353298-vr5hnzp8 171 5 , , , cord-353298-vr5hnzp8 171 6 O-2A O-2A NNP cord-353298-vr5hnzp8 171 7 progenitor progenitor NN cord-353298-vr5hnzp8 171 8 cells cell NNS cord-353298-vr5hnzp8 171 9 represented represent VBN cord-353298-vr5hnzp8 171 10 , , , cord-353298-vr5hnzp8 171 11 , , , cord-353298-vr5hnzp8 171 12 020 020 CD cord-353298-vr5hnzp8 171 13 % % NN cord-353298-vr5hnzp8 171 14 of of IN cord-353298-vr5hnzp8 171 15 the the DT cord-353298-vr5hnzp8 171 16 O-2A O-2A NNP cord-353298-vr5hnzp8 171 17 lineage lineage NN cord-353298-vr5hnzp8 171 18 population population NN cord-353298-vr5hnzp8 171 19 . . . cord-353298-vr5hnzp8 172 1 A a DT cord-353298-vr5hnzp8 172 2 remarkable remarkable JJ cord-353298-vr5hnzp8 172 3 feature feature NN cord-353298-vr5hnzp8 172 4 in in IN cord-353298-vr5hnzp8 172 5 cultures culture NNS cord-353298-vr5hnzp8 172 6 from from IN cord-353298-vr5hnzp8 172 7 demyelinated demyelinated JJ cord-353298-vr5hnzp8 172 8 tissue tissue NN cord-353298-vr5hnzp8 172 9 was be VBD cord-353298-vr5hnzp8 172 10 the the DT cord-353298-vr5hnzp8 172 11 presence presence NN cord-353298-vr5hnzp8 172 12 of of IN cord-353298-vr5hnzp8 172 13 mixed mixed JJ cord-353298-vr5hnzp8 172 14 oligodendrocyte oligodendrocyte NNP cord-353298-vr5hnzp8 172 15 - - HYPH cord-353298-vr5hnzp8 172 16 astrocyte astrocyte JJ cord-353298-vr5hnzp8 172 17 phenotype phenotype NN cord-353298-vr5hnzp8 172 18 cells cell NNS cord-353298-vr5hnzp8 172 19 , , , cord-353298-vr5hnzp8 172 20 which which WDT cord-353298-vr5hnzp8 172 21 were be VBD cord-353298-vr5hnzp8 172 22 rarely rarely RB cord-353298-vr5hnzp8 172 23 seen see VBN cord-353298-vr5hnzp8 172 24 in in IN cord-353298-vr5hnzp8 172 25 control control NN cord-353298-vr5hnzp8 172 26 cultures culture NNS cord-353298-vr5hnzp8 173 1 ( ( -LRB- cord-353298-vr5hnzp8 173 2 Fig Fig NNP cord-353298-vr5hnzp8 173 3 . . NNP cord-353298-vr5hnzp8 173 4 5 5 CD cord-353298-vr5hnzp8 173 5 ) ) -RRB- cord-353298-vr5hnzp8 173 6 . . . cord-353298-vr5hnzp8 174 1 These these DT cord-353298-vr5hnzp8 174 2 cells cell NNS cord-353298-vr5hnzp8 174 3 expressed express VBD cord-353298-vr5hnzp8 174 4 GC GC NNP cord-353298-vr5hnzp8 174 5 on on IN cord-353298-vr5hnzp8 174 6 their -PRON- PRP$ cord-353298-vr5hnzp8 174 7 surface surface NN cord-353298-vr5hnzp8 174 8 and and CC cord-353298-vr5hnzp8 174 9 contained contain VBD cord-353298-vr5hnzp8 174 10 intracellular intracellular JJ cord-353298-vr5hnzp8 174 11 filaments filament NNS cord-353298-vr5hnzp8 174 12 immunostained immunostaine VBN cord-353298-vr5hnzp8 174 13 with with IN cord-353298-vr5hnzp8 174 14 GFAP GFAP NNP cord-353298-vr5hnzp8 175 1 ( ( -LRB- cord-353298-vr5hnzp8 175 2 Fig Fig NNP cord-353298-vr5hnzp8 175 3 . . . cord-353298-vr5hnzp8 175 4 8) 8) NNP cord-353298-vr5hnzp8 175 5 . . . cord-353298-vr5hnzp8 176 1 Such such JJ cord-353298-vr5hnzp8 176 2 mixed mixed JJ cord-353298-vr5hnzp8 176 3 phenotype phenotype NN cord-353298-vr5hnzp8 176 4 cells cell NNS cord-353298-vr5hnzp8 176 5 ( ( -LRB- cord-353298-vr5hnzp8 176 6 04 04 CD cord-353298-vr5hnzp8 176 7 + + CC cord-353298-vr5hnzp8 176 8 GC+ GC+ NNP cord-353298-vr5hnzp8 176 9 GFAP+ GFAP+ NNP cord-353298-vr5hnzp8 176 10 ) ) -RRB- cord-353298-vr5hnzp8 176 11 were be VBD cord-353298-vr5hnzp8 176 12 found find VBN cord-353298-vr5hnzp8 176 13 consistently consistently RB cord-353298-vr5hnzp8 176 14 using use VBG cord-353298-vr5hnzp8 176 15 two two CD cord-353298-vr5hnzp8 176 16 different different JJ cord-353298-vr5hnzp8 176 17 antibodies antibody NNS cord-353298-vr5hnzp8 176 18 to to IN cord-353298-vr5hnzp8 176 19 GC GC NNP cord-353298-vr5hnzp8 176 20 in in IN cord-353298-vr5hnzp8 176 21 combination combination NN cord-353298-vr5hnzp8 176 22 with with IN cord-353298-vr5hnzp8 176 23 two two CD cord-353298-vr5hnzp8 176 24 different different JJ cord-353298-vr5hnzp8 176 25 antibodies antibody NNS cord-353298-vr5hnzp8 176 26 to to IN cord-353298-vr5hnzp8 176 27 GFAP GFAP NNP cord-353298-vr5hnzp8 176 28 ( ( -LRB- cord-353298-vr5hnzp8 176 29 see see VB cord-353298-vr5hnzp8 176 30 Materials material NNS cord-353298-vr5hnzp8 176 31 and and CC cord-353298-vr5hnzp8 176 32 Methods Methods NNPS cord-353298-vr5hnzp8 176 33 ) ) -RRB- cord-353298-vr5hnzp8 176 34 . . . cord-353298-vr5hnzp8 177 1 Certain certain JJ cord-353298-vr5hnzp8 177 2 growth growth NN cord-353298-vr5hnzp8 177 3 factors factor NNS cord-353298-vr5hnzp8 177 4 have have VBP cord-353298-vr5hnzp8 177 5 been be VBN cord-353298-vr5hnzp8 177 6 shown show VBN cord-353298-vr5hnzp8 177 7 to to TO cord-353298-vr5hnzp8 177 8 have have VB cord-353298-vr5hnzp8 177 9 an an DT cord-353298-vr5hnzp8 177 10 effect effect NN cord-353298-vr5hnzp8 177 11 on on IN cord-353298-vr5hnzp8 177 12 the the DT cord-353298-vr5hnzp8 177 13 fate fate NN cord-353298-vr5hnzp8 177 14 of of IN cord-353298-vr5hnzp8 177 15 O-2A O-2A NNP cord-353298-vr5hnzp8 177 16 lineage lineage NN cord-353298-vr5hnzp8 177 17 cells cell NNS cord-353298-vr5hnzp8 177 18 : : : cord-353298-vr5hnzp8 177 19 IGF IGF NNP cord-353298-vr5hnzp8 177 20 - - : cord-353298-vr5hnzp8 177 21 I -PRON- PRP cord-353298-vr5hnzp8 177 22 promotes promote VBZ cord-353298-vr5hnzp8 177 23 oligodendrocyte oligodendrocyte NNP cord-353298-vr5hnzp8 177 24 development development NN cord-353298-vr5hnzp8 177 25 ( ( -LRB- cord-353298-vr5hnzp8 177 26 McMorris McMorris NNP cord-353298-vr5hnzp8 177 27 et et NNP cord-353298-vr5hnzp8 177 28 al al NNP cord-353298-vr5hnzp8 177 29 . . NNP cord-353298-vr5hnzp8 177 30 , , , cord-353298-vr5hnzp8 177 31 1986 1986 CD cord-353298-vr5hnzp8 177 32 ) ) -RRB- cord-353298-vr5hnzp8 177 33 , , , cord-353298-vr5hnzp8 177 34 whereas whereas IN cord-353298-vr5hnzp8 177 35 bFGF bfgf NN cord-353298-vr5hnzp8 177 36 inhibits inhibit VBZ cord-353298-vr5hnzp8 177 37 myelin myelin NN cord-353298-vr5hnzp8 177 38 gene gene NN cord-353298-vr5hnzp8 177 39 expression expression NN cord-353298-vr5hnzp8 177 40 ( ( -LRB- cord-353298-vr5hnzp8 177 41 McKirmon McKirmon NNP cord-353298-vr5hnzp8 177 42 and and CC cord-353298-vr5hnzp8 177 43 Dubois Dubois NNP cord-353298-vr5hnzp8 177 44 - - HYPH cord-353298-vr5hnzp8 177 45 Dalcq Dalcq NNP cord-353298-vr5hnzp8 177 46 , , , cord-353298-vr5hnzp8 177 47 1990 1990 CD cord-353298-vr5hnzp8 177 48 ) ) -RRB- cord-353298-vr5hnzp8 177 49 . . . cord-353298-vr5hnzp8 178 1 Therefore therefore RB cord-353298-vr5hnzp8 178 2 , , , cord-353298-vr5hnzp8 178 3 we -PRON- PRP cord-353298-vr5hnzp8 178 4 examined examine VBD cord-353298-vr5hnzp8 178 5 whether whether IN cord-353298-vr5hnzp8 178 6 treatment treatment NN cord-353298-vr5hnzp8 178 7 with with IN cord-353298-vr5hnzp8 178 8 such such JJ cord-353298-vr5hnzp8 178 9 growth growth NN cord-353298-vr5hnzp8 178 10 factors factor NNS cord-353298-vr5hnzp8 178 11 from from IN cord-353298-vr5hnzp8 178 12 1 1 CD cord-353298-vr5hnzp8 178 13 - - SYM cord-353298-vr5hnzp8 178 14 3 3 CD cord-353298-vr5hnzp8 178 15 div div NN cord-353298-vr5hnzp8 178 16 would would MD cord-353298-vr5hnzp8 178 17 influence influence VB cord-353298-vr5hnzp8 178 18 the the DT cord-353298-vr5hnzp8 178 19 antigenic antigenic JJ cord-353298-vr5hnzp8 178 20 phenotypes phenotype NNS cord-353298-vr5hnzp8 178 21 expressed express VBN cord-353298-vr5hnzp8 178 22 by by IN cord-353298-vr5hnzp8 178 23 O-2A O-2A NNP cord-353298-vr5hnzp8 178 24 lineage lineage NN cord-353298-vr5hnzp8 178 25 cells cell NNS cord-353298-vr5hnzp8 178 26 isolated isolate VBN cord-353298-vr5hnzp8 178 27 during during IN cord-353298-vr5hnzp8 178 28 the the DT cord-353298-vr5hnzp8 178 29 course course NN cord-353298-vr5hnzp8 178 30 of of IN cord-353298-vr5hnzp8 178 31 demyelination demyelination NN cord-353298-vr5hnzp8 178 32 and and CC cord-353298-vr5hnzp8 178 33 remyelination remyelination NN cord-353298-vr5hnzp8 178 34 ( ( -LRB- cord-353298-vr5hnzp8 178 35 Fig Fig NNP cord-353298-vr5hnzp8 178 36 . . . cord-353298-vr5hnzp8 178 37 9 9 CD cord-353298-vr5hnzp8 178 38 ) ) -RRB- cord-353298-vr5hnzp8 178 39 . . . cord-353298-vr5hnzp8 179 1 In in IN cord-353298-vr5hnzp8 179 2 cultures culture NNS cord-353298-vr5hnzp8 179 3 of of IN cord-353298-vr5hnzp8 179 4 demyelinating demyelinate VBG cord-353298-vr5hnzp8 179 5 / / SYM cord-353298-vr5hnzp8 179 6 remyelinating remyelinate VBG cord-353298-vr5hnzp8 179 7 tissue tissue NN cord-353298-vr5hnzp8 179 8 exogenous exogenous JJ cord-353298-vr5hnzp8 179 9 IGF IGF NNP cord-353298-vr5hnzp8 179 10 - - HYPH cord-353298-vr5hnzp8 179 11 I -PRON- PRP cord-353298-vr5hnzp8 179 12 increased increase VBD cord-353298-vr5hnzp8 179 13 the the DT cord-353298-vr5hnzp8 179 14 proportion proportion NN cord-353298-vr5hnzp8 179 15 of of IN cord-353298-vr5hnzp8 179 16 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 179 17 relative relative JJ cord-353298-vr5hnzp8 179 18 to to IN cord-353298-vr5hnzp8 179 19 type type NN cord-353298-vr5hnzp8 179 20 2 2 CD cord-353298-vr5hnzp8 179 21 astrocytes astrocyte NNS cord-353298-vr5hnzp8 179 22 , , , cord-353298-vr5hnzp8 179 23 whereas whereas IN cord-353298-vr5hnzp8 179 24 bFGF bfgf NN cord-353298-vr5hnzp8 179 25 decreased decrease VBD cord-353298-vr5hnzp8 179 26 the the DT cord-353298-vr5hnzp8 179 27 relative relative JJ cord-353298-vr5hnzp8 179 28 number number NN cord-353298-vr5hnzp8 179 29 of of IN cord-353298-vr5hnzp8 179 30 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 179 31 . . . cord-353298-vr5hnzp8 180 1 PDGF PDGF NNP cord-353298-vr5hnzp8 180 2 did do VBD cord-353298-vr5hnzp8 180 3 not not RB cord-353298-vr5hnzp8 180 4 markedly markedly RB cord-353298-vr5hnzp8 180 5 alter alter VB cord-353298-vr5hnzp8 180 6 the the DT cord-353298-vr5hnzp8 180 7 ratio ratio NN cord-353298-vr5hnzp8 180 8 of of IN cord-353298-vr5hnzp8 180 9 type type NN cord-353298-vr5hnzp8 180 10 2 2 CD cord-353298-vr5hnzp8 180 11 astrocytes astrocyte NNS cord-353298-vr5hnzp8 180 12 to to IN cord-353298-vr5hnzp8 180 13 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 180 14 , , , cord-353298-vr5hnzp8 180 15 in in IN cord-353298-vr5hnzp8 180 16 agreement agreement NN cord-353298-vr5hnzp8 180 17 with with IN cord-353298-vr5hnzp8 180 18 the the DT cord-353298-vr5hnzp8 180 19 observation observation NN cord-353298-vr5hnzp8 180 20 that that IN cord-353298-vr5hnzp8 180 21 PDGF PDGF NNP cord-353298-vr5hnzp8 180 22 allows allow VBZ cord-353298-vr5hnzp8 180 23 timely timely JJ cord-353298-vr5hnzp8 180 24 differentiation differentiation NN cord-353298-vr5hnzp8 180 25 of of IN cord-353298-vr5hnzp8 180 26 oligodendroeytes oligodendroeyte NNS cord-353298-vr5hnzp8 180 27 and and CC cord-353298-vr5hnzp8 180 28 type type NN cord-353298-vr5hnzp8 180 29 2 2 CD cord-353298-vr5hnzp8 180 30 astroeytes astroeyte NNS cord-353298-vr5hnzp8 180 31 in in IN cord-353298-vr5hnzp8 180 32 cultures culture NNS cord-353298-vr5hnzp8 180 33 of of IN cord-353298-vr5hnzp8 180 34 developing develop VBG cord-353298-vr5hnzp8 180 35 CNS CNS NNP cord-353298-vr5hnzp8 180 36 tissue tissue NN cord-353298-vr5hnzp8 180 37 Raft Raft NNP cord-353298-vr5hnzp8 180 38 et et FW cord-353298-vr5hnzp8 180 39 al al NNP cord-353298-vr5hnzp8 180 40 . . NNP cord-353298-vr5hnzp8 180 41 , , , cord-353298-vr5hnzp8 180 42 1988 1988 CD cord-353298-vr5hnzp8 180 43 ) ) -RRB- cord-353298-vr5hnzp8 180 44 . . . cord-353298-vr5hnzp8 181 1 In in IN cord-353298-vr5hnzp8 181 2 a a DT cord-353298-vr5hnzp8 181 3 previous previous JJ cord-353298-vr5hnzp8 181 4 in in IN cord-353298-vr5hnzp8 181 5 vivo vivo NN cord-353298-vr5hnzp8 181 6 study study NN cord-353298-vr5hnzp8 181 7 of of IN cord-353298-vr5hnzp8 181 8 this this DT cord-353298-vr5hnzp8 181 9 demyelinating demyelinating JJ cord-353298-vr5hnzp8 181 10 disease disease NN cord-353298-vr5hnzp8 181 11 , , , cord-353298-vr5hnzp8 181 12 O-2A O-2A NNP cord-353298-vr5hnzp8 181 13 lineage lineage NN cord-353298-vr5hnzp8 181 14 cells cell NNS cord-353298-vr5hnzp8 181 15 which which WDT cord-353298-vr5hnzp8 181 16 had have VBD cord-353298-vr5hnzp8 181 17 incorporated incorporate VBN cord-353298-vr5hnzp8 181 18 [ [ -LRB- cord-353298-vr5hnzp8 181 19 3I 3i NN cord-353298-vr5hnzp8 181 20 - - HYPH cord-353298-vr5hnzp8 181 21 l]thymidine l]thymidine NNP cord-353298-vr5hnzp8 181 22 during during IN cord-353298-vr5hnzp8 181 23 a a DT cord-353298-vr5hnzp8 181 24 2-h 2-h CD cord-353298-vr5hnzp8 181 25 terminal terminal NN cord-353298-vr5hnzp8 181 26 pulse pulse NN cord-353298-vr5hnzp8 181 27 were be VBD cord-353298-vr5hnzp8 181 28 detected detect VBN cord-353298-vr5hnzp8 181 29 in in IN cord-353298-vr5hnzp8 181 30 1 1 CD cord-353298-vr5hnzp8 181 31 - - HYPH cord-353298-vr5hnzp8 181 32 1zm 1zm CD cord-353298-vr5hnzp8 181 33 frozen frozen JJ cord-353298-vr5hnzp8 181 34 sec- sec- NN cord-353298-vr5hnzp8 181 35 tions tion NNS cord-353298-vr5hnzp8 181 36 ( ( -LRB- cord-353298-vr5hnzp8 181 37 Godfraind Godfraind NNP cord-353298-vr5hnzp8 181 38 et et NNP cord-353298-vr5hnzp8 181 39 al al NNP cord-353298-vr5hnzp8 181 40 . . NNP cord-353298-vr5hnzp8 181 41 , , , cord-353298-vr5hnzp8 181 42 1989 1989 CD cord-353298-vr5hnzp8 181 43 ) ) -RRB- cord-353298-vr5hnzp8 181 44 . . . cord-353298-vr5hnzp8 182 1 To to TO cord-353298-vr5hnzp8 182 2 further further RB cord-353298-vr5hnzp8 182 3 explore explore VB cord-353298-vr5hnzp8 182 4 the the DT cord-353298-vr5hnzp8 182 5 mitotic mitotic JJ cord-353298-vr5hnzp8 182 6 potential potential NN cord-353298-vr5hnzp8 182 7 of of IN cord-353298-vr5hnzp8 182 8 O-2A O-2A NNP cord-353298-vr5hnzp8 182 9 lineage lineage NN cord-353298-vr5hnzp8 182 10 cells cell NNS cord-353298-vr5hnzp8 182 11 from from IN cord-353298-vr5hnzp8 182 12 adult adult NN cord-353298-vr5hnzp8 182 13 CNS CNS NNP cord-353298-vr5hnzp8 182 14 , , , cord-353298-vr5hnzp8 182 15 we -PRON- PRP cord-353298-vr5hnzp8 182 16 prepared prepare VBD cord-353298-vr5hnzp8 182 17 cultures culture NNS cord-353298-vr5hnzp8 182 18 from from IN cord-353298-vr5hnzp8 182 19 spinal spinal JJ cord-353298-vr5hnzp8 182 20 cords cord NNS cord-353298-vr5hnzp8 182 21 of of IN cord-353298-vr5hnzp8 182 22 normal normal JJ cord-353298-vr5hnzp8 182 23 and and CC cord-353298-vr5hnzp8 182 24 infected infected JJ cord-353298-vr5hnzp8 182 25 mice mouse NNS cord-353298-vr5hnzp8 182 26 after after IN cord-353298-vr5hnzp8 182 27 in in IN cord-353298-vr5hnzp8 182 28 vivo vivo NN cord-353298-vr5hnzp8 182 29 labeling labeling NN cord-353298-vr5hnzp8 182 30 with with IN cord-353298-vr5hnzp8 182 31 [ [ -LRB- cord-353298-vr5hnzp8 182 32 3H]thymidine 3h]thymidine CD cord-353298-vr5hnzp8 182 33 during during IN cord-353298-vr5hnzp8 182 34 a a DT cord-353298-vr5hnzp8 182 35 2-h 2-h CD cord-353298-vr5hnzp8 182 36 terminal terminal NN cord-353298-vr5hnzp8 182 37 pulse pulse NN cord-353298-vr5hnzp8 183 1 ( ( -LRB- cord-353298-vr5hnzp8 183 2 Table table NN cord-353298-vr5hnzp8 183 3 I i CD cord-353298-vr5hnzp8 183 4 ) ) -RRB- cord-353298-vr5hnzp8 183 5 . . . cord-353298-vr5hnzp8 184 1 Cells cell NNS cord-353298-vr5hnzp8 184 2 undergoing undergo VBG cord-353298-vr5hnzp8 184 3 active active JJ cord-353298-vr5hnzp8 184 4 DNA dna NN cord-353298-vr5hnzp8 184 5 synthesis synthesis NN cord-353298-vr5hnzp8 184 6 were be VBD cord-353298-vr5hnzp8 184 7 identified identify VBN cord-353298-vr5hnzp8 184 8 after after IN cord-353298-vr5hnzp8 184 9 1 1 CD cord-353298-vr5hnzp8 184 10 div div NN cord-353298-vr5hnzp8 184 11 by by IN cord-353298-vr5hnzp8 184 12 [ [ -LRB- cord-353298-vr5hnzp8 184 13 3I 3i CD cord-353298-vr5hnzp8 184 14 - - HYPH cord-353298-vr5hnzp8 184 15 I]thymidine I]thymidine NNP cord-353298-vr5hnzp8 184 16 autoradiography autoradiography NN cord-353298-vr5hnzp8 184 17 combined combine VBN cord-353298-vr5hnzp8 184 18 with with IN cord-353298-vr5hnzp8 184 19 triple triple JJ cord-353298-vr5hnzp8 184 20 - - HYPH cord-353298-vr5hnzp8 184 21 label label NN cord-353298-vr5hnzp8 184 22 immunocytochemistry immunocytochemistry NN cord-353298-vr5hnzp8 184 23 , , , cord-353298-vr5hnzp8 184 24 as as IN cord-353298-vr5hnzp8 184 25 outlined outline VBN cord-353298-vr5hnzp8 184 26 in in IN cord-353298-vr5hnzp8 184 27 Fig Fig NNP cord-353298-vr5hnzp8 184 28 . . . cord-353298-vr5hnzp8 185 1 1 1 CD cord-353298-vr5hnzp8 185 2 A. a. NN cord-353298-vr5hnzp8 186 1 The the DT cord-353298-vr5hnzp8 186 2 proportion proportion NN cord-353298-vr5hnzp8 186 3 of of IN cord-353298-vr5hnzp8 186 4 O-2A O-2A NNP cord-353298-vr5hnzp8 186 5 lineage lineage NN cord-353298-vr5hnzp8 186 6 cells cell NNS cord-353298-vr5hnzp8 186 7 ( ( -LRB- cord-353298-vr5hnzp8 186 8 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 186 9 , , , cord-353298-vr5hnzp8 186 10 O-2A O-2A NNP cord-353298-vr5hnzp8 186 11 progenitors progenitor NNS cord-353298-vr5hnzp8 186 12 , , , cord-353298-vr5hnzp8 186 13 and and CC cord-353298-vr5hnzp8 186 14 type type NN cord-353298-vr5hnzp8 186 15 2 2 CD cord-353298-vr5hnzp8 186 16 astrocytes astrocyte NNS cord-353298-vr5hnzp8 186 17 ) ) -RRB- cord-353298-vr5hnzp8 186 18 which which WDT cord-353298-vr5hnzp8 186 19 were be VBD cord-353298-vr5hnzp8 186 20 thymidine thymidine NN cord-353298-vr5hnzp8 186 21 - - HYPH cord-353298-vr5hnzp8 186 22 labeled label VBN cord-353298-vr5hnzp8 186 23 was be VBD cord-353298-vr5hnzp8 186 24 extremely extremely RB cord-353298-vr5hnzp8 186 25 low low JJ cord-353298-vr5hnzp8 186 26 in in IN cord-353298-vr5hnzp8 186 27 control control NN cord-353298-vr5hnzp8 186 28 cultures culture NNS cord-353298-vr5hnzp8 186 29 prepared prepare VBN cord-353298-vr5hnzp8 186 30 from from IN cord-353298-vr5hnzp8 186 31 normal normal JJ cord-353298-vr5hnzp8 186 32 mice mouse NNS cord-353298-vr5hnzp8 186 33 at at IN cord-353298-vr5hnzp8 186 34 5 5 CD cord-353298-vr5hnzp8 186 35 wk wk NN cord-353298-vr5hnzp8 186 36 of of IN cord-353298-vr5hnzp8 186 37 age age NN cord-353298-vr5hnzp8 186 38 ( ( -LRB- cord-353298-vr5hnzp8 186 39 0.52 0.52 CD cord-353298-vr5hnzp8 186 40 % % NN cord-353298-vr5hnzp8 186 41 ) ) -RRB- cord-353298-vr5hnzp8 186 42 and and CC cord-353298-vr5hnzp8 186 43 at at IN cord-353298-vr5hnzp8 186 44 8 8 CD cord-353298-vr5hnzp8 186 45 wk wk NN cord-353298-vr5hnzp8 186 46 of of IN cord-353298-vr5hnzp8 186 47 age age NN cord-353298-vr5hnzp8 186 48 ( ( -LRB- cord-353298-vr5hnzp8 186 49 0 0 CD cord-353298-vr5hnzp8 186 50 % % NN cord-353298-vr5hnzp8 186 51 ) ) -RRB- cord-353298-vr5hnzp8 186 52 . . . cord-353298-vr5hnzp8 187 1 In in IN cord-353298-vr5hnzp8 187 2 contrast contrast NN cord-353298-vr5hnzp8 187 3 , , , cord-353298-vr5hnzp8 187 4 the the DT cord-353298-vr5hnzp8 187 5 proportion proportion NN cord-353298-vr5hnzp8 187 6 of of IN cord-353298-vr5hnzp8 187 7 O-2A O-2A NNP cord-353298-vr5hnzp8 187 8 lineage lineage NN cord-353298-vr5hnzp8 187 9 cells cell NNS cord-353298-vr5hnzp8 187 10 ( ( -LRB- cord-353298-vr5hnzp8 187 11 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 187 12 , , , cord-353298-vr5hnzp8 187 13 O-2A O-2A NNP cord-353298-vr5hnzp8 187 14 progenitors progenitor NNS cord-353298-vr5hnzp8 187 15 , , , cord-353298-vr5hnzp8 187 16 type type NN cord-353298-vr5hnzp8 187 17 2 2 CD cord-353298-vr5hnzp8 187 18 astrocytes astrocyte NNS cord-353298-vr5hnzp8 187 19 , , , cord-353298-vr5hnzp8 187 20 and and CC cord-353298-vr5hnzp8 187 21 mixed mixed JJ cord-353298-vr5hnzp8 187 22 phenotype phenotype NN cord-353298-vr5hnzp8 187 23 cells cell NNS cord-353298-vr5hnzp8 187 24 ) ) -RRB- cord-353298-vr5hnzp8 187 25 that that WDT cord-353298-vr5hnzp8 187 26 were be VBD cord-353298-vr5hnzp8 187 27 pH]thymidine pH]thymidine NNP cord-353298-vr5hnzp8 187 28 - - HYPH cord-353298-vr5hnzp8 187 29 labeled label VBN cord-353298-vr5hnzp8 187 30 in in IN cord-353298-vr5hnzp8 187 31 cultures culture NNS cord-353298-vr5hnzp8 187 32 derived derive VBN cord-353298-vr5hnzp8 187 33 from from IN cord-353298-vr5hnzp8 187 34 infected infected JJ cord-353298-vr5hnzp8 187 35 tissue tissue NN cord-353298-vr5hnzp8 187 36 was be VBD cord-353298-vr5hnzp8 187 37 markedly markedly RB cord-353298-vr5hnzp8 187 38 higher high JJR cord-353298-vr5hnzp8 187 39 both both DT cord-353298-vr5hnzp8 187 40 in in IN cord-353298-vr5hnzp8 187 41 the the DT cord-353298-vr5hnzp8 187 42 early early JJ cord-353298-vr5hnzp8 187 43 phase phase NN cord-353298-vr5hnzp8 187 44 of of IN cord-353298-vr5hnzp8 187 45 the the DT cord-353298-vr5hnzp8 187 46 disease disease NN cord-353298-vr5hnzp8 187 47 ( ( -LRB- cord-353298-vr5hnzp8 187 48 4.96 4.96 CD cord-353298-vr5hnzp8 187 49 % % NN cord-353298-vr5hnzp8 187 50 at at IN cord-353298-vr5hnzp8 187 51 1 1 CD cord-353298-vr5hnzp8 187 52 wpi wpi NN cord-353298-vr5hnzp8 187 53 ; ; : cord-353298-vr5hnzp8 187 54 5 5 CD cord-353298-vr5hnzp8 187 55 wk wk NN cord-353298-vr5hnzp8 187 56 of of IN cord-353298-vr5hnzp8 187 57 age age NN cord-353298-vr5hnzp8 187 58 ) ) -RRB- cord-353298-vr5hnzp8 187 59 and and CC cord-353298-vr5hnzp8 187 60 at at IN cord-353298-vr5hnzp8 187 61 the the DT cord-353298-vr5hnzp8 187 62 time time NN cord-353298-vr5hnzp8 187 63 of of IN cord-353298-vr5hnzp8 187 64 widespread widespread JJ cord-353298-vr5hnzp8 187 65 demyelination demyelination NN cord-353298-vr5hnzp8 187 66 ( ( -LRB- cord-353298-vr5hnzp8 187 67 5.38 5.38 CD cord-353298-vr5hnzp8 187 68 % % NN cord-353298-vr5hnzp8 187 69 at at IN cord-353298-vr5hnzp8 187 70 4 4 CD cord-353298-vr5hnzp8 187 71 wpi wpi NN cord-353298-vr5hnzp8 187 72 ; ; : cord-353298-vr5hnzp8 187 73 8 8 CD cord-353298-vr5hnzp8 187 74 wk wk NN cord-353298-vr5hnzp8 187 75 of of IN cord-353298-vr5hnzp8 187 76 age age NN cord-353298-vr5hnzp8 187 77 ) ) -RRB- cord-353298-vr5hnzp8 187 78 . . . cord-353298-vr5hnzp8 188 1 We -PRON- PRP cord-353298-vr5hnzp8 188 2 next next RB cord-353298-vr5hnzp8 188 3 examined examine VBD cord-353298-vr5hnzp8 188 4 the the DT cord-353298-vr5hnzp8 188 5 proliferative proliferative JJ cord-353298-vr5hnzp8 188 6 capacity capacity NN cord-353298-vr5hnzp8 188 7 of of IN cord-353298-vr5hnzp8 188 8 the the DT cord-353298-vr5hnzp8 188 9 cultured cultured JJ cord-353298-vr5hnzp8 188 10 cells cell NNS cord-353298-vr5hnzp8 188 11 during during IN cord-353298-vr5hnzp8 188 12 an an DT cord-353298-vr5hnzp8 188 13 in in FW cord-353298-vr5hnzp8 188 14 vitro vitro FW cord-353298-vr5hnzp8 188 15 pulse pulse NN cord-353298-vr5hnzp8 188 16 of of IN cord-353298-vr5hnzp8 188 17 [ [ -LRB- cord-353298-vr5hnzp8 188 18 3H]thymidine 3h]thymidine CD cord-353298-vr5hnzp8 188 19 ( ( -LRB- cord-353298-vr5hnzp8 188 20 Table table NN cord-353298-vr5hnzp8 188 21 _SP cord-353298-vr5hnzp8 188 22 I i NN cord-353298-vr5hnzp8 188 23 ) ) -RRB- cord-353298-vr5hnzp8 188 24 . . . cord-353298-vr5hnzp8 189 1 In in IN cord-353298-vr5hnzp8 189 2 this this DT cord-353298-vr5hnzp8 189 3 case case NN cord-353298-vr5hnzp8 189 4 proliferation proliferation NN cord-353298-vr5hnzp8 189 5 in in IN cord-353298-vr5hnzp8 189 6 vitro vitro FW cord-353298-vr5hnzp8 189 7 was be VBD cord-353298-vr5hnzp8 189 8 measured measure VBN cord-353298-vr5hnzp8 189 9 by by IN cord-353298-vr5hnzp8 189 10 adding add VBG cord-353298-vr5hnzp8 189 11 [ [ -LRB- cord-353298-vr5hnzp8 189 12 SH sh NN cord-353298-vr5hnzp8 189 13 ] ] -RRB- cord-353298-vr5hnzp8 189 14 thymidine thymidine NN cord-353298-vr5hnzp8 189 15 to to IN cord-353298-vr5hnzp8 189 16 the the DT cord-353298-vr5hnzp8 189 17 culture culture NN cord-353298-vr5hnzp8 189 18 medium medium NN cord-353298-vr5hnzp8 189 19 at at IN cord-353298-vr5hnzp8 189 20 2 2 CD cord-353298-vr5hnzp8 189 21 div div NN cord-353298-vr5hnzp8 189 22 , , , cord-353298-vr5hnzp8 189 23 fixing fix VBG cord-353298-vr5hnzp8 189 24 the the DT cord-353298-vr5hnzp8 189 25 cells cell NNS cord-353298-vr5hnzp8 189 26 20 20 CD cord-353298-vr5hnzp8 189 27 h h NN cord-353298-vr5hnzp8 189 28 later later RB cord-353298-vr5hnzp8 189 29 , , , cord-353298-vr5hnzp8 189 30 and and CC cord-353298-vr5hnzp8 189 31 then then RB cord-353298-vr5hnzp8 189 32 identifying identify VBG cord-353298-vr5hnzp8 189 33 [ [ -LRB- cord-353298-vr5hnzp8 189 34 3H]thymidine 3h]thymidine CD cord-353298-vr5hnzp8 189 35 - - HYPH cord-353298-vr5hnzp8 189 36 labeled label VBN cord-353298-vr5hnzp8 189 37 cells cell NNS cord-353298-vr5hnzp8 189 38 by by IN cord-353298-vr5hnzp8 189 39 autoradiography autoradiography NN cord-353298-vr5hnzp8 189 40 combined combine VBN cord-353298-vr5hnzp8 189 41 with with IN cord-353298-vr5hnzp8 189 42 three three CD cord-353298-vr5hnzp8 189 43 - - HYPH cord-353298-vr5hnzp8 189 44 fluorochrome fluorochrome NN cord-353298-vr5hnzp8 189 45 immunocytochemistry immunocytochemistry NN cord-353298-vr5hnzp8 189 46 , , , cord-353298-vr5hnzp8 189 47 as as IN cord-353298-vr5hnzp8 189 48 outlined outline VBN cord-353298-vr5hnzp8 189 49 in in IN cord-353298-vr5hnzp8 189 50 Fig Fig NNP cord-353298-vr5hnzp8 189 51 . . . cord-353298-vr5hnzp8 190 1 1 1 CD cord-353298-vr5hnzp8 190 2 B. B. NNP cord-353298-vr5hnzp8 191 1 The the DT cord-353298-vr5hnzp8 191 2 percentage percentage NN cord-353298-vr5hnzp8 191 3 of of IN cord-353298-vr5hnzp8 191 4 O-2A O-2A NNP cord-353298-vr5hnzp8 191 5 lineage lineage NN cord-353298-vr5hnzp8 191 6 cells cell NNS cord-353298-vr5hnzp8 191 7 that that WDT cord-353298-vr5hnzp8 191 8 were be VBD cord-353298-vr5hnzp8 191 9 labeled label VBN cord-353298-vr5hnzp8 191 10 in in IN cord-353298-vr5hnzp8 191 11 vitro vitro FW cord-353298-vr5hnzp8 191 12 with with IN cord-353298-vr5hnzp8 191 13 pH]thymidine pH]thymidine NNP cord-353298-vr5hnzp8 191 14 was be VBD cord-353298-vr5hnzp8 191 15 approximately approximately RB cord-353298-vr5hnzp8 191 16 ninefold ninefold JJ cord-353298-vr5hnzp8 191 17 higher higher RBR cord-353298-vr5hnzp8 191 18 in in IN cord-353298-vr5hnzp8 191 19 cultures culture NNS cord-353298-vr5hnzp8 191 20 derived derive VBN cord-353298-vr5hnzp8 191 21 from from IN cord-353298-vr5hnzp8 191 22 diseased diseased JJ cord-353298-vr5hnzp8 191 23 mice mouse NNS cord-353298-vr5hnzp8 191 24 at at IN cord-353298-vr5hnzp8 191 25 1 1 CD cord-353298-vr5hnzp8 191 26 wpi wpi NN cord-353298-vr5hnzp8 191 27 than than IN cord-353298-vr5hnzp8 191 28 in in IN cord-353298-vr5hnzp8 191 29 cultures culture NNS cord-353298-vr5hnzp8 191 30 from from IN cord-353298-vr5hnzp8 191 31 age age NN cord-353298-vr5hnzp8 191 32 - - HYPH cord-353298-vr5hnzp8 191 33 matched match VBN cord-353298-vr5hnzp8 191 34 control control NN cord-353298-vr5hnzp8 191 35 mice mouse NNS cord-353298-vr5hnzp8 191 36 , , , cord-353298-vr5hnzp8 191 37 and and CC cord-353298-vr5hnzp8 191 38 was be VBD cord-353298-vr5hnzp8 191 39 increased increase VBN cord-353298-vr5hnzp8 191 40 more more RBR cord-353298-vr5hnzp8 191 41 than than IN cord-353298-vr5hnzp8 191 42 threefold threefold RB cord-353298-vr5hnzp8 191 43 at at IN cord-353298-vr5hnzp8 191 44 4 4 CD cord-353298-vr5hnzp8 191 45 wpi wpi NN cord-353298-vr5hnzp8 191 46 ( ( -LRB- cord-353298-vr5hnzp8 191 47 Table table NN cord-353298-vr5hnzp8 191 48 I i CD cord-353298-vr5hnzp8 191 49 ) ) -RRB- cord-353298-vr5hnzp8 191 50 . . . cord-353298-vr5hnzp8 192 1 Oligodendrocytes Oligodendrocytes NNP cord-353298-vr5hnzp8 192 2 ( ( -LRB- cord-353298-vr5hnzp8 192 3 Fig Fig NNP cord-353298-vr5hnzp8 192 4 . . . cord-353298-vr5hnzp8 192 5 10 10 CD cord-353298-vr5hnzp8 192 6 ) ) -RRB- cord-353298-vr5hnzp8 192 7 , , , cord-353298-vr5hnzp8 192 8 type type NN cord-353298-vr5hnzp8 192 9 2 2 CD cord-353298-vr5hnzp8 192 10 astrocytes astrocyte NNS cord-353298-vr5hnzp8 192 11 ( ( -LRB- cord-353298-vr5hnzp8 192 12 Fig Fig NNP cord-353298-vr5hnzp8 192 13 . . . cord-353298-vr5hnzp8 192 14 11 11 CD cord-353298-vr5hnzp8 192 15 ) ) -RRB- cord-353298-vr5hnzp8 192 16 , , , cord-353298-vr5hnzp8 192 17 O-2A O-2A NNP cord-353298-vr5hnzp8 192 18 progenitors progenitor NNS cord-353298-vr5hnzp8 192 19 ( ( -LRB- cord-353298-vr5hnzp8 192 20 Fig Fig NNP cord-353298-vr5hnzp8 192 21 . . . cord-353298-vr5hnzp8 192 22 12 12 CD cord-353298-vr5hnzp8 192 23 ) ) -RRB- cord-353298-vr5hnzp8 192 24 , , , cord-353298-vr5hnzp8 192 25 and and CC cord-353298-vr5hnzp8 192 26 mixed mixed JJ cord-353298-vr5hnzp8 192 27 phenotype phenotype NN cord-353298-vr5hnzp8 192 28 cells cell NNS cord-353298-vr5hnzp8 192 29 were be VBD cord-353298-vr5hnzp8 192 30 labeled label VBN cord-353298-vr5hnzp8 192 31 with with IN cord-353298-vr5hnzp8 192 32 [ [ -LRB- cord-353298-vr5hnzp8 192 33 3H]thymidine 3h]thymidine CD cord-353298-vr5hnzp8 192 34 after after IN cord-353298-vr5hnzp8 192 35 the the DT cord-353298-vr5hnzp8 192 36 20-h 20-h CD cord-353298-vr5hnzp8 192 37 terminal terminal NN cord-353298-vr5hnzp8 192 38 pulse pulse NN cord-353298-vr5hnzp8 192 39 . . . cord-353298-vr5hnzp8 193 1 Remarkably remarkably RB cord-353298-vr5hnzp8 193 2 , , , cord-353298-vr5hnzp8 193 3 O-2A O-2A NNP cord-353298-vr5hnzp8 193 4 progenitors progenitor NNS cord-353298-vr5hnzp8 193 5 were be VBD cord-353298-vr5hnzp8 193 6 the the DT cord-353298-vr5hnzp8 193 7 only only JJ cord-353298-vr5hnzp8 193 8 cell cell NN cord-353298-vr5hnzp8 193 9 type type NN cord-353298-vr5hnzp8 193 10 for for IN cord-353298-vr5hnzp8 193 11 which which WDT cord-353298-vr5hnzp8 193 12 the the DT cord-353298-vr5hnzp8 193 13 increased increase VBN cord-353298-vr5hnzp8 193 14 percentage percentage NN cord-353298-vr5hnzp8 193 15 of of IN cord-353298-vr5hnzp8 193 16 [ [ -LRB- cord-353298-vr5hnzp8 193 17 3H]thymidine 3h]thymidine CD cord-353298-vr5hnzp8 193 18 - - HYPH cord-353298-vr5hnzp8 193 19 labeled label VBN cord-353298-vr5hnzp8 193 20 cells cell NNS cord-353298-vr5hnzp8 193 21 from from IN cord-353298-vr5hnzp8 193 22 demyelinated demyelinated JJ cord-353298-vr5hnzp8 193 23 tissue tissue NN cord-353298-vr5hnzp8 193 24 was be VBD cord-353298-vr5hnzp8 193 25 highly highly RB cord-353298-vr5hnzp8 193 26 significant significant JJ cord-353298-vr5hnzp8 193 27 ( ( -LRB- cord-353298-vr5hnzp8 193 28 4 4 CD cord-353298-vr5hnzp8 193 29 wpi wpi NN cord-353298-vr5hnzp8 193 30 ; ; : cord-353298-vr5hnzp8 193 31 demyelinated demyelinated NNP cord-353298-vr5hnzp8 193 32 = = SYM cord-353298-vr5hnzp8 193 33 38.3 38.3 CD cord-353298-vr5hnzp8 193 34 % % NN cord-353298-vr5hnzp8 193 35 , , , cord-353298-vr5hnzp8 193 36 control control NN cord-353298-vr5hnzp8 194 1 = = NFP cord-353298-vr5hnzp8 194 2 Figure Figure NNP cord-353298-vr5hnzp8 194 3 8 8 CD cord-353298-vr5hnzp8 194 4 . . . cord-353298-vr5hnzp8 195 1 A a DT cord-353298-vr5hnzp8 195 2 cell cell NN cord-353298-vr5hnzp8 195 3 with with IN cord-353298-vr5hnzp8 195 4 a a DT cord-353298-vr5hnzp8 195 5 mixed mixed JJ cord-353298-vr5hnzp8 195 6 oligodendrocyteastrocyte oligodendrocyteastrocyte NN cord-353298-vr5hnzp8 195 7 phenotype phenotype NN cord-353298-vr5hnzp8 195 8 isolated isolate VBN cord-353298-vr5hnzp8 195 9 from from IN cord-353298-vr5hnzp8 195 10 demyelinated demyelinated JJ cord-353298-vr5hnzp8 195 11 tissue tissue NN cord-353298-vr5hnzp8 195 12 ( ( -LRB- cord-353298-vr5hnzp8 195 13 4 4 CD cord-353298-vr5hnzp8 195 14 wpi wpi NN cord-353298-vr5hnzp8 195 15 ) ) -RRB- cord-353298-vr5hnzp8 195 16 which which WDT cord-353298-vr5hnzp8 195 17 was be VBD cord-353298-vr5hnzp8 195 18 grown grow VBN cord-353298-vr5hnzp8 195 19 in in IN cord-353298-vr5hnzp8 195 20 culture culture NN cord-353298-vr5hnzp8 195 21 for for IN cord-353298-vr5hnzp8 195 22 3 3 CD cord-353298-vr5hnzp8 195 23 d d NN cord-353298-vr5hnzp8 195 24 , , , cord-353298-vr5hnzp8 195 25 fixed fix VBN cord-353298-vr5hnzp8 195 26 , , , cord-353298-vr5hnzp8 195 27 and and CC cord-353298-vr5hnzp8 195 28 processed process VBN cord-353298-vr5hnzp8 195 29 for for IN cord-353298-vr5hnzp8 195 30 three three CD cord-353298-vr5hnzp8 195 31 - - HYPH cord-353298-vr5hnzp8 195 32 color color NN cord-353298-vr5hnzp8 195 33 immunofluorescence immunofluorescence NN cord-353298-vr5hnzp8 195 34 . . . cord-353298-vr5hnzp8 196 1 ( ( -LRB- cord-353298-vr5hnzp8 196 2 A a NN cord-353298-vr5hnzp8 196 3 ) ) -RRB- cord-353298-vr5hnzp8 196 4 The the DT cord-353298-vr5hnzp8 196 5 cell cell NN cord-353298-vr5hnzp8 196 6 surface surface NN cord-353298-vr5hnzp8 196 7 membrane membrane NN cord-353298-vr5hnzp8 196 8 is be VBZ cord-353298-vr5hnzp8 196 9 immunostained immunostaine VBN cord-353298-vr5hnzp8 196 10 with with IN cord-353298-vr5hnzp8 196 11 an an DT cord-353298-vr5hnzp8 196 12 mAb mab NN cord-353298-vr5hnzp8 196 13 against against IN cord-353298-vr5hnzp8 196 14 GC GC NNP cord-353298-vr5hnzp8 196 15 , , , cord-353298-vr5hnzp8 196 16 visualized visualize VBN cord-353298-vr5hnzp8 196 17 with with IN cord-353298-vr5hnzp8 196 18 fluorescein fluorescein NN cord-353298-vr5hnzp8 196 19 . . . cord-353298-vr5hnzp8 197 1 ( ( -LRB- cord-353298-vr5hnzp8 197 2 B b NN cord-353298-vr5hnzp8 197 3 ) ) -RRB- cord-353298-vr5hnzp8 198 1 Intracellular Intracellular NNP cord-353298-vr5hnzp8 198 2 filaments filament NNS cord-353298-vr5hnzp8 198 3 are be VBP cord-353298-vr5hnzp8 198 4 immunostained immunostaine VBN cord-353298-vr5hnzp8 198 5 with with IN cord-353298-vr5hnzp8 198 6 a a DT cord-353298-vr5hnzp8 198 7 polyclonal polyclonal JJ cord-353298-vr5hnzp8 198 8 antiserum antiserum NN cord-353298-vr5hnzp8 198 9 recognizing recognize VBG cord-353298-vr5hnzp8 198 10 GFAP GFAP NNP cord-353298-vr5hnzp8 198 11 , , , cord-353298-vr5hnzp8 198 12 visualized visualize VBN cord-353298-vr5hnzp8 198 13 with with IN cord-353298-vr5hnzp8 198 14 coumarin coumarin NN cord-353298-vr5hnzp8 198 15 . . . cord-353298-vr5hnzp8 199 1 This this DT cord-353298-vr5hnzp8 199 2 cell cell NN cord-353298-vr5hnzp8 199 3 was be VBD cord-353298-vr5hnzp8 199 4 also also RB cord-353298-vr5hnzp8 199 5 labeled label VBN cord-353298-vr5hnzp8 199 6 by by IN cord-353298-vr5hnzp8 199 7 04 04 CD cord-353298-vr5hnzp8 199 8 , , , cord-353298-vr5hnzp8 199 9 visualized visualize VBN cord-353298-vr5hnzp8 199 10 with with IN cord-353298-vr5hnzp8 199 11 rhodamine rhodamine NN cord-353298-vr5hnzp8 199 12 ( ( -LRB- cord-353298-vr5hnzp8 199 13 not not RB cord-353298-vr5hnzp8 199 14 shown show VBN cord-353298-vr5hnzp8 199 15 ) ) -RRB- cord-353298-vr5hnzp8 199 16 . . . cord-353298-vr5hnzp8 200 1 Bar bar NN cord-353298-vr5hnzp8 200 2 , , , cord-353298-vr5hnzp8 200 3 50 50 CD cord-353298-vr5hnzp8 200 4 ttm ttm NNS cord-353298-vr5hnzp8 200 5 . . NNP cord-353298-vr5hnzp8 200 6 0 0 CD cord-353298-vr5hnzp8 200 7 % % NN cord-353298-vr5hnzp8 200 8 ; ; : cord-353298-vr5hnzp8 200 9 p p NN cord-353298-vr5hnzp8 200 10 = = SYM cord-353298-vr5hnzp8 200 11 0.027 0.027 CD cord-353298-vr5hnzp8 200 12 , , , cord-353298-vr5hnzp8 200 13 as as IN cord-353298-vr5hnzp8 200 14 determined determine VBN cord-353298-vr5hnzp8 200 15 by by IN cord-353298-vr5hnzp8 200 16 paired pair VBN cord-353298-vr5hnzp8 200 17 two two CD cord-353298-vr5hnzp8 200 18 - - HYPH cord-353298-vr5hnzp8 200 19 tailed tailed JJ cord-353298-vr5hnzp8 200 20 t t NN cord-353298-vr5hnzp8 200 21 test test NN cord-353298-vr5hnzp8 200 22 ) ) -RRB- cord-353298-vr5hnzp8 200 23 . . . cord-353298-vr5hnzp8 201 1 Approximately approximately RB cord-353298-vr5hnzp8 201 2 12 12 CD cord-353298-vr5hnzp8 201 3 - - SYM cord-353298-vr5hnzp8 201 4 14 14 CD cord-353298-vr5hnzp8 201 5 % % NN cord-353298-vr5hnzp8 201 6 of of IN cord-353298-vr5hnzp8 201 7 each each DT cord-353298-vr5hnzp8 201 8 of of IN cord-353298-vr5hnzp8 201 9 the the DT cord-353298-vr5hnzp8 201 10 other other JJ cord-353298-vr5hnzp8 201 11 O-2A O-2A NNP cord-353298-vr5hnzp8 201 12 lineage lineage NN cord-353298-vr5hnzp8 201 13 cell cell NN cord-353298-vr5hnzp8 201 14 types type NNS cord-353298-vr5hnzp8 201 15 ( ( -LRB- cord-353298-vr5hnzp8 201 16 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 201 17 , , , cord-353298-vr5hnzp8 201 18 type type NN cord-353298-vr5hnzp8 201 19 2 2 CD cord-353298-vr5hnzp8 201 20 astrocytes astrocyte NNS cord-353298-vr5hnzp8 201 21 , , , cord-353298-vr5hnzp8 201 22 and and CC cord-353298-vr5hnzp8 201 23 mixed mixed JJ cord-353298-vr5hnzp8 201 24 phenotype phenotype NN cord-353298-vr5hnzp8 201 25 cells cell NNS cord-353298-vr5hnzp8 201 26 ) ) -RRB- cord-353298-vr5hnzp8 201 27 were be VBD cord-353298-vr5hnzp8 201 28 pH]thymidine pH]thymidine NNP cord-353298-vr5hnzp8 201 29 - - HYPH cord-353298-vr5hnzp8 201 30 labeled label VBN cord-353298-vr5hnzp8 201 31 in in IN cord-353298-vr5hnzp8 201 32 cultures culture NNS cord-353298-vr5hnzp8 201 33 derived derive VBN cord-353298-vr5hnzp8 201 34 from from IN cord-353298-vr5hnzp8 201 35 demyelinated demyelinated JJ cord-353298-vr5hnzp8 201 36 tissue tissue NN cord-353298-vr5hnzp8 201 37 . . . cord-353298-vr5hnzp8 202 1 Although although IN cord-353298-vr5hnzp8 202 2 the the DT cord-353298-vr5hnzp8 202 3 percentage percentage NN cord-353298-vr5hnzp8 202 4 of of IN cord-353298-vr5hnzp8 202 5 [ [ -LRB- cord-353298-vr5hnzp8 202 6 3H]thymidine 3h]thymidine CD cord-353298-vr5hnzp8 202 7 - - HYPH cord-353298-vr5hnzp8 202 8 labeled label VBN cord-353298-vr5hnzp8 202 9 cells cell NNS cord-353298-vr5hnzp8 202 10 within within IN cord-353298-vr5hnzp8 202 11 each each DT cord-353298-vr5hnzp8 202 12 of of IN cord-353298-vr5hnzp8 202 13 these these DT cord-353298-vr5hnzp8 202 14 phenotypes phenotype NNS cord-353298-vr5hnzp8 202 15 alone alone RB cord-353298-vr5hnzp8 202 16 was be VBD cord-353298-vr5hnzp8 202 17 not not RB cord-353298-vr5hnzp8 202 18 increased increase VBN cord-353298-vr5hnzp8 202 19 significantly significantly RB cord-353298-vr5hnzp8 202 20 , , , cord-353298-vr5hnzp8 202 21 when when WRB cord-353298-vr5hnzp8 202 22 combined combine VBN cord-353298-vr5hnzp8 202 23 as as IN cord-353298-vr5hnzp8 202 24 a a DT cord-353298-vr5hnzp8 202 25 single single JJ cord-353298-vr5hnzp8 202 26 group group NN cord-353298-vr5hnzp8 202 27 these these DT cord-353298-vr5hnzp8 202 28 three three CD cord-353298-vr5hnzp8 202 29 phenotypes phenotype NNS cord-353298-vr5hnzp8 202 30 accounted account VBD cord-353298-vr5hnzp8 202 31 for for IN cord-353298-vr5hnzp8 202 32 a a DT cord-353298-vr5hnzp8 202 33 significant significant JJ cord-353298-vr5hnzp8 202 34 proliferative proliferative JJ cord-353298-vr5hnzp8 202 35 response response NN cord-353298-vr5hnzp8 202 36 in in IN cord-353298-vr5hnzp8 202 37 cultures culture NNS cord-353298-vr5hnzp8 202 38 of of IN cord-353298-vr5hnzp8 202 39 demyelinated demyelinated JJ cord-353298-vr5hnzp8 202 40 tissue tissue NN cord-353298-vr5hnzp8 202 41 ( ( -LRB- cord-353298-vr5hnzp8 202 42 4 4 CD cord-353298-vr5hnzp8 202 43 wpi wpi NN cord-353298-vr5hnzp8 202 44 ; ; : cord-353298-vr5hnzp8 202 45 demyelinated demyelinated NNP cord-353298-vr5hnzp8 202 46 = = SYM cord-353298-vr5hnzp8 202 47 13.5 13.5 CD cord-353298-vr5hnzp8 202 48 % % NN cord-353298-vr5hnzp8 202 49 , , , cord-353298-vr5hnzp8 202 50 control control NN cord-353298-vr5hnzp8 202 51 = = SYM cord-353298-vr5hnzp8 202 52 4.3 4.3 CD cord-353298-vr5hnzp8 202 53 % % NN cord-353298-vr5hnzp8 202 54 ; ; : cord-353298-vr5hnzp8 202 55 p p NN cord-353298-vr5hnzp8 202 56 = = SYM cord-353298-vr5hnzp8 202 57 0.029 0.029 CD cord-353298-vr5hnzp8 202 58 , , , cord-353298-vr5hnzp8 202 59 as as IN cord-353298-vr5hnzp8 202 60 determined determine VBN cord-353298-vr5hnzp8 202 61 by by IN cord-353298-vr5hnzp8 202 62 paired pair VBN cord-353298-vr5hnzp8 202 63 two two CD cord-353298-vr5hnzp8 202 64 - - HYPH cord-353298-vr5hnzp8 202 65 tailed tailed JJ cord-353298-vr5hnzp8 202 66 t t NN cord-353298-vr5hnzp8 202 67 test test NN cord-353298-vr5hnzp8 202 68 ) ) -RRB- cord-353298-vr5hnzp8 202 69 . . . cord-353298-vr5hnzp8 203 1 Thus thus RB cord-353298-vr5hnzp8 203 2 the the DT cord-353298-vr5hnzp8 203 3 in in IN cord-353298-vr5hnzp8 203 4 vivo vivo FW cord-353298-vr5hnzp8 203 5 proliferative proliferative JJ cord-353298-vr5hnzp8 203 6 response response NN cord-353298-vr5hnzp8 203 7 of of IN cord-353298-vr5hnzp8 203 8 O-2A O-2A NNP cord-353298-vr5hnzp8 203 9 lineage lineage NN cord-353298-vr5hnzp8 203 10 cells cell NNS cord-353298-vr5hnzp8 203 11 isolated isolate VBN cord-353298-vr5hnzp8 203 12 from from IN cord-353298-vr5hnzp8 203 13 demyelinating demyelinate VBG cord-353298-vr5hnzp8 203 14 tissues tissue NNS cord-353298-vr5hnzp8 203 15 was be VBD cord-353298-vr5hnzp8 203 16 retained retain VBN cord-353298-vr5hnzp8 203 17 in in IN cord-353298-vr5hnzp8 203 18 vitro vitro FW cord-353298-vr5hnzp8 203 19 . . . cord-353298-vr5hnzp8 204 1 Since since IN cord-353298-vr5hnzp8 204 2 PDGF PDGF NNP cord-353298-vr5hnzp8 204 3 , , , cord-353298-vr5hnzp8 204 4 IGF IGF NNP cord-353298-vr5hnzp8 204 5 - - HYPH cord-353298-vr5hnzp8 204 6 I I NNP cord-353298-vr5hnzp8 204 7 , , , cord-353298-vr5hnzp8 204 8 and and CC cord-353298-vr5hnzp8 204 9 bFGF bfgf NN cord-353298-vr5hnzp8 204 10 can can MD cord-353298-vr5hnzp8 204 11 each each DT cord-353298-vr5hnzp8 204 12 induce induce VB cord-353298-vr5hnzp8 204 13 proliferation proliferation NN cord-353298-vr5hnzp8 204 14 of of IN cord-353298-vr5hnzp8 204 15 neonatal neonatal JJ cord-353298-vr5hnzp8 204 16 O-2A O-2A NNP cord-353298-vr5hnzp8 204 17 progenitor progenitor NN cord-353298-vr5hnzp8 204 18 cells cell NNS cord-353298-vr5hnzp8 204 19 in in IN cord-353298-vr5hnzp8 204 20 the the DT cord-353298-vr5hnzp8 204 21 developing develop VBG cord-353298-vr5hnzp8 204 22 rat rat NN cord-353298-vr5hnzp8 204 23 CNS CNS NNP cord-353298-vr5hnzp8 204 24 ( ( -LRB- cord-353298-vr5hnzp8 204 25 reviewed review VBN cord-353298-vr5hnzp8 204 26 in in IN cord-353298-vr5hnzp8 204 27 Dubois Dubois NNP cord-353298-vr5hnzp8 204 28 - - HYPH cord-353298-vr5hnzp8 204 29 Dalcq Dalcq NNP cord-353298-vr5hnzp8 204 30 and and CC cord-353298-vr5hnzp8 204 31 Armstrong Armstrong NNP cord-353298-vr5hnzp8 204 32 , , , cord-353298-vr5hnzp8 204 33 1990 1990 CD cord-353298-vr5hnzp8 204 34 ) ) -RRB- cord-353298-vr5hnzp8 204 35 , , , cord-353298-vr5hnzp8 204 36 we -PRON- PRP cord-353298-vr5hnzp8 204 37 assayed assay VBD cord-353298-vr5hnzp8 204 38 the the DT cord-353298-vr5hnzp8 204 39 mitogenic mitogenic JJ cord-353298-vr5hnzp8 204 40 effect effect NN cord-353298-vr5hnzp8 204 41 of of IN cord-353298-vr5hnzp8 204 42 these these DT cord-353298-vr5hnzp8 204 43 growth growth NN cord-353298-vr5hnzp8 204 44 factors factor NNS cord-353298-vr5hnzp8 204 45 in in IN cord-353298-vr5hnzp8 204 46 our -PRON- PRP$ cord-353298-vr5hnzp8 204 47 cultures culture NNS cord-353298-vr5hnzp8 204 48 of of IN cord-353298-vr5hnzp8 204 49 adult adult NN cord-353298-vr5hnzp8 204 50 mouse mouse NN cord-353298-vr5hnzp8 204 51 spinal spinal JJ cord-353298-vr5hnzp8 204 52 cord cord NN cord-353298-vr5hnzp8 204 53 ( ( -LRB- cord-353298-vr5hnzp8 204 54 see see VB cord-353298-vr5hnzp8 204 55 protocol protocol NN cord-353298-vr5hnzp8 204 56 outlined outline VBN cord-353298-vr5hnzp8 204 57 in in IN cord-353298-vr5hnzp8 204 58 Fig Fig NNP cord-353298-vr5hnzp8 204 59 . . . cord-353298-vr5hnzp8 204 60 1 1 CD cord-353298-vr5hnzp8 204 61 C C NNP cord-353298-vr5hnzp8 204 62 ) ) -RRB- cord-353298-vr5hnzp8 204 63 . . . cord-353298-vr5hnzp8 205 1 We -PRON- PRP cord-353298-vr5hnzp8 205 2 tested test VBD cord-353298-vr5hnzp8 205 3 each each DT cord-353298-vr5hnzp8 205 4 growth growth NN cord-353298-vr5hnzp8 205 5 factor factor NN cord-353298-vr5hnzp8 205 6 at at IN cord-353298-vr5hnzp8 205 7 1 1 CD cord-353298-vr5hnzp8 205 8 , , , cord-353298-vr5hnzp8 205 9 3 3 CD cord-353298-vr5hnzp8 205 10 , , , cord-353298-vr5hnzp8 205 11 4 4 CD cord-353298-vr5hnzp8 205 12 , , , cord-353298-vr5hnzp8 205 13 5 5 CD cord-353298-vr5hnzp8 205 14 , , , cord-353298-vr5hnzp8 205 15 and and CC cord-353298-vr5hnzp8 205 16 8 8 CD cord-353298-vr5hnzp8 205 17 wpi wpi NN cord-353298-vr5hnzp8 205 18 since since IN cord-353298-vr5hnzp8 205 19 the the DT cord-353298-vr5hnzp8 205 20 effect effect NN cord-353298-vr5hnzp8 205 21 of of IN cord-353298-vr5hnzp8 205 22 a a DT cord-353298-vr5hnzp8 205 23 particular particular JJ cord-353298-vr5hnzp8 205 24 growth growth NN cord-353298-vr5hnzp8 205 25 factor factor NN cord-353298-vr5hnzp8 205 26 may may MD cord-353298-vr5hnzp8 205 27 vary vary VB cord-353298-vr5hnzp8 205 28 during during IN cord-353298-vr5hnzp8 205 29 the the DT cord-353298-vr5hnzp8 205 30 course course NN cord-353298-vr5hnzp8 205 31 of of IN cord-353298-vr5hnzp8 205 32 the the DT cord-353298-vr5hnzp8 205 33 disease disease NN cord-353298-vr5hnzp8 205 34 . . . cord-353298-vr5hnzp8 206 1 In in IN cord-353298-vr5hnzp8 206 2 cultures culture NNS cord-353298-vr5hnzp8 206 3 of of IN cord-353298-vr5hnzp8 206 4 demyelinating demyelinate VBG cord-353298-vr5hnzp8 206 5 and and CC cord-353298-vr5hnzp8 206 6 remyelinating remyelinate VBG cord-353298-vr5hnzp8 206 7 tissue tissue NN cord-353298-vr5hnzp8 206 8 , , , cord-353298-vr5hnzp8 206 9 none none NN cord-353298-vr5hnzp8 206 10 of of IN cord-353298-vr5hnzp8 206 11 these these DT cord-353298-vr5hnzp8 206 12 three three CD cord-353298-vr5hnzp8 206 13 growth growth NN cord-353298-vr5hnzp8 206 14 factors factor NNS cord-353298-vr5hnzp8 206 15 caused cause VBD cord-353298-vr5hnzp8 206 16 a a DT cord-353298-vr5hnzp8 206 17 significant significant JJ cord-353298-vr5hnzp8 206 18 increase increase NN cord-353298-vr5hnzp8 206 19 in in IN cord-353298-vr5hnzp8 206 20 the the DT cord-353298-vr5hnzp8 206 21 percentage percentage NN cord-353298-vr5hnzp8 206 22 of of IN cord-353298-vr5hnzp8 206 23 O-2A O-2A NNP cord-353298-vr5hnzp8 206 24 lineage lineage NN cord-353298-vr5hnzp8 206 25 cells cell NNS cord-353298-vr5hnzp8 206 26 which which WDT cord-353298-vr5hnzp8 206 27 incorporate incorporate VBP cord-353298-vr5hnzp8 206 28 pH]thymidine pH]thymidine NNP cord-353298-vr5hnzp8 206 29 during during IN cord-353298-vr5hnzp8 206 30 a a DT cord-353298-vr5hnzp8 206 31 20-h 20-h CD cord-353298-vr5hnzp8 206 32 terminal terminal NN cord-353298-vr5hnzp8 206 33 pulse pulse NN cord-353298-vr5hnzp8 206 34 ( ( -LRB- cord-353298-vr5hnzp8 206 35 p p NN cord-353298-vr5hnzp8 206 36 = = SYM cord-353298-vr5hnzp8 206 37 0.691 0.691 CD cord-353298-vr5hnzp8 206 38 for for IN cord-353298-vr5hnzp8 206 39 the the DT cord-353298-vr5hnzp8 206 40 difference difference NN cord-353298-vr5hnzp8 206 41 between between IN cord-353298-vr5hnzp8 206 42 treatments treatment NNS cord-353298-vr5hnzp8 206 43 , , , cord-353298-vr5hnzp8 206 44 as as IN cord-353298-vr5hnzp8 206 45 determined determine VBN cord-353298-vr5hnzp8 206 46 by by IN cord-353298-vr5hnzp8 206 47 ANOVA ANOVA NNP cord-353298-vr5hnzp8 206 48 ) ) -RRB- cord-353298-vr5hnzp8 206 49 . . . cord-353298-vr5hnzp8 207 1 Similarly similarly RB cord-353298-vr5hnzp8 207 2 , , , cord-353298-vr5hnzp8 207 3 preliminary preliminary JJ cord-353298-vr5hnzp8 207 4 data datum NNS cord-353298-vr5hnzp8 207 5 from from IN cord-353298-vr5hnzp8 207 6 control control NN cord-353298-vr5hnzp8 207 7 cultures culture NNS cord-353298-vr5hnzp8 207 8 indicated indicate VBD cord-353298-vr5hnzp8 207 9 that that IN cord-353298-vr5hnzp8 207 10 treatment treatment NN cord-353298-vr5hnzp8 207 11 with with IN cord-353298-vr5hnzp8 207 12 PDGF PDGF NNP cord-353298-vr5hnzp8 207 13 , , , cord-353298-vr5hnzp8 207 14 IGF IGF NNP cord-353298-vr5hnzp8 207 15 - - HYPH cord-353298-vr5hnzp8 207 16 I I NNP cord-353298-vr5hnzp8 207 17 , , , cord-353298-vr5hnzp8 207 18 or or CC cord-353298-vr5hnzp8 207 19 bFGF bfgf NN cord-353298-vr5hnzp8 207 20 did do VBD cord-353298-vr5hnzp8 207 21 not not RB cord-353298-vr5hnzp8 207 22 enhance enhance VB cord-353298-vr5hnzp8 207 23 the the DT cord-353298-vr5hnzp8 207 24 proliferation proliferation NN cord-353298-vr5hnzp8 207 25 of of IN cord-353298-vr5hnzp8 207 26 O-2A O-2A NNP cord-353298-vr5hnzp8 207 27 lineage lineage NN cord-353298-vr5hnzp8 207 28 cells cell NNS cord-353298-vr5hnzp8 207 29 from from IN cord-353298-vr5hnzp8 207 30 normal normal JJ cord-353298-vr5hnzp8 207 31 adult adult NN cord-353298-vr5hnzp8 207 32 mice mouse NNS cord-353298-vr5hnzp8 207 33 . . . cord-353298-vr5hnzp8 208 1 Thus thus RB cord-353298-vr5hnzp8 208 2 , , , cord-353298-vr5hnzp8 208 3 exogenous exogenous JJ cord-353298-vr5hnzp8 208 4 growth growth NN cord-353298-vr5hnzp8 208 5 factors factor NNS cord-353298-vr5hnzp8 208 6 influenced influence VBN cord-353298-vr5hnzp8 208 7 phenotype phenotype NN cord-353298-vr5hnzp8 208 8 expression expression NN cord-353298-vr5hnzp8 208 9 ( ( -LRB- cord-353298-vr5hnzp8 208 10 Fig Fig NNP cord-353298-vr5hnzp8 208 11 . . . cord-353298-vr5hnzp8 208 12 9 9 CD cord-353298-vr5hnzp8 208 13 ) ) -RRB- cord-353298-vr5hnzp8 208 14 but but CC cord-353298-vr5hnzp8 208 15 did do VBD cord-353298-vr5hnzp8 208 16 not not RB cord-353298-vr5hnzp8 208 17 enhance enhance VB cord-353298-vr5hnzp8 208 18 the the DT cord-353298-vr5hnzp8 208 19 proliferation proliferation NN cord-353298-vr5hnzp8 208 20 of of IN cord-353298-vr5hnzp8 208 21 O-2A O-2A NNP cord-353298-vr5hnzp8 208 22 lineage lineage NN cord-353298-vr5hnzp8 208 23 cells cell NNS cord-353298-vr5hnzp8 208 24 in in IN cord-353298-vr5hnzp8 208 25 our -PRON- PRP$ cord-353298-vr5hnzp8 208 26 cultures culture NNS cord-353298-vr5hnzp8 208 27 . . . cord-353298-vr5hnzp8 209 1 In in IN cord-353298-vr5hnzp8 209 2 the the DT cord-353298-vr5hnzp8 209 3 present present NN cord-353298-vr5hnzp8 209 4 in in IN cord-353298-vr5hnzp8 209 5 vitro vitro FW cord-353298-vr5hnzp8 209 6 study study NN cord-353298-vr5hnzp8 209 7 , , , cord-353298-vr5hnzp8 209 8 we -PRON- PRP cord-353298-vr5hnzp8 209 9 have have VBP cord-353298-vr5hnzp8 209 10 characterized characterize VBN cord-353298-vr5hnzp8 209 11 the the DT cord-353298-vr5hnzp8 209 12 growth growth NN cord-353298-vr5hnzp8 209 13 and and CC cord-353298-vr5hnzp8 209 14 differentiation differentiation NN cord-353298-vr5hnzp8 209 15 of of IN cord-353298-vr5hnzp8 209 16 glial glial JJ cord-353298-vr5hnzp8 209 17 cells cell NNS cord-353298-vr5hnzp8 209 18 isolated isolate VBN cord-353298-vr5hnzp8 209 19 from from IN cord-353298-vr5hnzp8 209 20 the the DT cord-353298-vr5hnzp8 209 21 CNS CNS NNP cord-353298-vr5hnzp8 209 22 of of IN cord-353298-vr5hnzp8 209 23 mice mouse NNS cord-353298-vr5hnzp8 209 24 during during IN cord-353298-vr5hnzp8 209 25 the the DT cord-353298-vr5hnzp8 209 26 course course NN cord-353298-vr5hnzp8 209 27 of of IN cord-353298-vr5hnzp8 209 28 demyelination demyelination NN cord-353298-vr5hnzp8 209 29 and and CC cord-353298-vr5hnzp8 209 30 remy- remy- NN cord-353298-vr5hnzp8 209 31 Figure figure NN cord-353298-vr5hnzp8 209 32 9 9 CD cord-353298-vr5hnzp8 209 33 . . . cord-353298-vr5hnzp8 210 1 The the DT cord-353298-vr5hnzp8 210 2 relative relative JJ cord-353298-vr5hnzp8 210 3 abundance abundance NN cord-353298-vr5hnzp8 210 4 of of IN cord-353298-vr5hnzp8 210 5 type type NN cord-353298-vr5hnzp8 210 6 2 2 CD cord-353298-vr5hnzp8 210 7 astrocytes astrocyte NNS cord-353298-vr5hnzp8 210 8 and and CC cord-353298-vr5hnzp8 210 9 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 210 10 in in IN cord-353298-vr5hnzp8 210 11 spinal spinal JJ cord-353298-vr5hnzp8 210 12 cord cord NN cord-353298-vr5hnzp8 210 13 cultures culture NNS cord-353298-vr5hnzp8 210 14 from from IN cord-353298-vr5hnzp8 210 15 virus virus NN cord-353298-vr5hnzp8 210 16 - - HYPH cord-353298-vr5hnzp8 210 17 inoculated inoculate VBN cord-353298-vr5hnzp8 210 18 animals animal NNS cord-353298-vr5hnzp8 210 19 . . . cord-353298-vr5hnzp8 211 1 The the DT cord-353298-vr5hnzp8 211 2 number number NN cord-353298-vr5hnzp8 211 3 of of IN cord-353298-vr5hnzp8 211 4 type type NN cord-353298-vr5hnzp8 211 5 2 2 CD cord-353298-vr5hnzp8 211 6 astrocytes astrocyte NNS cord-353298-vr5hnzp8 211 7 and and CC cord-353298-vr5hnzp8 211 8 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 211 9 was be VBD cord-353298-vr5hnzp8 211 10 determined determine VBN cord-353298-vr5hnzp8 211 11 as as IN cord-353298-vr5hnzp8 211 12 described describe VBN cord-353298-vr5hnzp8 211 13 in in IN cord-353298-vr5hnzp8 211 14 Fig Fig NNP cord-353298-vr5hnzp8 211 15 . . . cord-353298-vr5hnzp8 212 1 5 5 LS cord-353298-vr5hnzp8 212 2 . . . cord-353298-vr5hnzp8 213 1 In in IN cord-353298-vr5hnzp8 213 2 defined define VBN cord-353298-vr5hnzp8 213 3 media medium NNS cord-353298-vr5hnzp8 213 4 alone alone RB cord-353298-vr5hnzp8 213 5 , , , cord-353298-vr5hnzp8 213 6 the the DT cord-353298-vr5hnzp8 213 7 proportion proportion NN cord-353298-vr5hnzp8 213 8 of of IN cord-353298-vr5hnzp8 213 9 type type NN cord-353298-vr5hnzp8 213 10 2 2 CD cord-353298-vr5hnzp8 213 11 astrocytes astrocyte NNS cord-353298-vr5hnzp8 213 12 increases increase NNS cord-353298-vr5hnzp8 213 13 during during IN cord-353298-vr5hnzp8 213 14 demyelination demyelination NN cord-353298-vr5hnzp8 213 15 ( ( -LRB- cord-353298-vr5hnzp8 213 16 3 3 CD cord-353298-vr5hnzp8 213 17 - - SYM cord-353298-vr5hnzp8 213 18 5 5 CD cord-353298-vr5hnzp8 213 19 wpi wpi NN cord-353298-vr5hnzp8 213 20 ) ) -RRB- cord-353298-vr5hnzp8 213 21 . . . cord-353298-vr5hnzp8 214 1 Addition addition NN cord-353298-vr5hnzp8 214 2 of of IN cord-353298-vr5hnzp8 214 3 bFGF bfgf NN cord-353298-vr5hnzp8 214 4 ( ( -LRB- cord-353298-vr5hnzp8 214 5 10 10 CD cord-353298-vr5hnzp8 214 6 ng ng NNP cord-353298-vr5hnzp8 214 7 / / SYM cord-353298-vr5hnzp8 214 8 nd nd NNP cord-353298-vr5hnzp8 214 9 ) ) -RRB- cord-353298-vr5hnzp8 214 10 to to IN cord-353298-vr5hnzp8 214 11 the the DT cord-353298-vr5hnzp8 214 12 defined define VBN cord-353298-vr5hnzp8 214 13 media medium NNS cord-353298-vr5hnzp8 214 14 between between IN cord-353298-vr5hnzp8 214 15 1 1 CD cord-353298-vr5hnzp8 214 16 and and CC cord-353298-vr5hnzp8 214 17 3 3 CD cord-353298-vr5hnzp8 214 18 div div NNP cord-353298-vr5hnzp8 214 19 exaggerates exaggerate VBZ cord-353298-vr5hnzp8 214 20 this this DT cord-353298-vr5hnzp8 214 21 shift shift NN cord-353298-vr5hnzp8 214 22 toward toward IN cord-353298-vr5hnzp8 214 23 the the DT cord-353298-vr5hnzp8 214 24 type type NN cord-353298-vr5hnzp8 214 25 2 2 CD cord-353298-vr5hnzp8 214 26 astrocyte astrocyte NN cord-353298-vr5hnzp8 214 27 phenotype phenotype NN cord-353298-vr5hnzp8 214 28 by by IN cord-353298-vr5hnzp8 214 29 decreasing decrease VBG cord-353298-vr5hnzp8 214 30 the the DT cord-353298-vr5hnzp8 214 31 relative relative JJ cord-353298-vr5hnzp8 214 32 number number NN cord-353298-vr5hnzp8 214 33 of of IN cord-353298-vr5hnzp8 214 34 cells cell NNS cord-353298-vr5hnzp8 214 35 expressing express VBG cord-353298-vr5hnzp8 214 36 GC GC NNP cord-353298-vr5hnzp8 214 37 . . . cord-353298-vr5hnzp8 215 1 Treatment treatment NN cord-353298-vr5hnzp8 215 2 with with IN cord-353298-vr5hnzp8 215 3 IGF IGF NNP cord-353298-vr5hnzp8 215 4 - - HYPH cord-353298-vr5hnzp8 215 5 I I NNP cord-353298-vr5hnzp8 215 6 ( ( -LRB- cord-353298-vr5hnzp8 215 7 100 100 CD cord-353298-vr5hnzp8 215 8 ng ng NN cord-353298-vr5hnzp8 215 9 / / SYM cord-353298-vr5hnzp8 215 10 ml ml NN cord-353298-vr5hnzp8 215 11 ) ) -RRB- cord-353298-vr5hnzp8 215 12 induces induce VBZ cord-353298-vr5hnzp8 215 13 a a DT cord-353298-vr5hnzp8 215 14 larger large JJR cord-353298-vr5hnzp8 215 15 proportion proportion NN cord-353298-vr5hnzp8 215 16 of of IN cord-353298-vr5hnzp8 215 17 cells cell NNS cord-353298-vr5hnzp8 215 18 to to TO cord-353298-vr5hnzp8 215 19 express express VB cord-353298-vr5hnzp8 215 20 the the DT cord-353298-vr5hnzp8 215 21 oligodendrocyte oligodendrocyte NNP cord-353298-vr5hnzp8 215 22 phenotype phenotype NN cord-353298-vr5hnzp8 215 23 . . . cord-353298-vr5hnzp8 216 1 Exogenous Exogenous NNP cord-353298-vr5hnzp8 216 2 PDGF PDGF NNP cord-353298-vr5hnzp8 216 3 ( ( -LRB- cord-353298-vr5hnzp8 216 4 10 10 CD cord-353298-vr5hnzp8 216 5 ng ng NN cord-353298-vr5hnzp8 216 6 / / SYM cord-353298-vr5hnzp8 216 7 ml ml NN cord-353298-vr5hnzp8 216 8 ) ) -RRB- cord-353298-vr5hnzp8 216 9 did do VBD cord-353298-vr5hnzp8 216 10 not not RB cord-353298-vr5hnzp8 216 11 alter alter VB cord-353298-vr5hnzp8 216 12 the the DT cord-353298-vr5hnzp8 216 13 ratio ratio NN cord-353298-vr5hnzp8 216 14 of of IN cord-353298-vr5hnzp8 216 15 type type NN cord-353298-vr5hnzp8 216 16 2 2 CD cord-353298-vr5hnzp8 216 17 astxo astxo NNP cord-353298-vr5hnzp8 216 18 ~ ~ NFP cord-353298-vr5hnzp8 216 19 tes tes FW cord-353298-vr5hnzp8 216 20 to to IN cord-353298-vr5hnzp8 216 21 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 216 22 . . . cord-353298-vr5hnzp8 217 1 To to TO cord-353298-vr5hnzp8 217 2 minimize minimize VB cord-353298-vr5hnzp8 217 3 variability variability NN cord-353298-vr5hnzp8 217 4 between between IN cord-353298-vr5hnzp8 217 5 experiments experiment NNS cord-353298-vr5hnzp8 217 6 , , , cord-353298-vr5hnzp8 217 7 the the DT cord-353298-vr5hnzp8 217 8 cultures culture NNS cord-353298-vr5hnzp8 217 9 were be VBD cord-353298-vr5hnzp8 217 10 prepared prepare VBN cord-353298-vr5hnzp8 217 11 in in IN cord-353298-vr5hnzp8 217 12 parallel parallel NN cord-353298-vr5hnzp8 217 13 for for IN cord-353298-vr5hnzp8 217 14 each each DT cord-353298-vr5hnzp8 217 15 timepoint timepoint NN cord-353298-vr5hnzp8 217 16 and and CC cord-353298-vr5hnzp8 217 17 as as IN cord-353298-vr5hnzp8 217 18 one one CD cord-353298-vr5hnzp8 217 19 completely completely RB cord-353298-vr5hnzp8 217 20 matched match VBN cord-353298-vr5hnzp8 217 21 set set NN cord-353298-vr5hnzp8 217 22 from from IN cord-353298-vr5hnzp8 217 23 mice mouse NNS cord-353298-vr5hnzp8 217 24 inoculated inoculate VBN cord-353298-vr5hnzp8 217 25 at at IN cord-353298-vr5hnzp8 217 26 the the DT cord-353298-vr5hnzp8 217 27 same same JJ cord-353298-vr5hnzp8 217 28 time time NN cord-353298-vr5hnzp8 217 29 with with IN cord-353298-vr5hnzp8 217 30 the the DT cord-353298-vr5hnzp8 217 31 demyelinating demyelinating JJ cord-353298-vr5hnzp8 217 32 virus virus NN cord-353298-vr5hnzp8 217 33 . . . cord-353298-vr5hnzp8 218 1 Each each DT cord-353298-vr5hnzp8 218 2 value value NN cord-353298-vr5hnzp8 218 3 represents represent VBZ cord-353298-vr5hnzp8 218 4 the the DT cord-353298-vr5hnzp8 218 5 ratio ratio NN cord-353298-vr5hnzp8 218 6 from from IN cord-353298-vr5hnzp8 218 7 cell cell NN cord-353298-vr5hnzp8 218 8 counts count NNS cord-353298-vr5hnzp8 218 9 in in IN cord-353298-vr5hnzp8 218 10 an an DT cord-353298-vr5hnzp8 218 11 entire entire JJ cord-353298-vr5hnzp8 218 12 35-mm 35-mm CD cord-353298-vr5hnzp8 218 13 dish dish NN cord-353298-vr5hnzp8 218 14 . . . cord-353298-vr5hnzp8 219 1 A a DT cord-353298-vr5hnzp8 219 2 total total NN cord-353298-vr5hnzp8 219 3 of of IN cord-353298-vr5hnzp8 219 4 1,793 1,793 CD cord-353298-vr5hnzp8 219 5 cells cell NNS cord-353298-vr5hnzp8 219 6 were be VBD cord-353298-vr5hnzp8 219 7 counted count VBN cord-353298-vr5hnzp8 219 8 in in IN cord-353298-vr5hnzp8 219 9 the the DT cord-353298-vr5hnzp8 219 10 set set NN cord-353298-vr5hnzp8 219 11 of of IN cord-353298-vr5hnzp8 219 12 cultures culture NNS cord-353298-vr5hnzp8 219 13 . . . cord-353298-vr5hnzp8 220 1 To to TO cord-353298-vr5hnzp8 220 2 estimate estimate VB cord-353298-vr5hnzp8 220 3 the the DT cord-353298-vr5hnzp8 220 4 variability variability NN cord-353298-vr5hnzp8 220 5 that that WDT cord-353298-vr5hnzp8 220 6 might may MD cord-353298-vr5hnzp8 220 7 be be VB cord-353298-vr5hnzp8 220 8 expected expect VBN cord-353298-vr5hnzp8 220 9 between between IN cord-353298-vr5hnzp8 220 10 nonmatched nonmatched JJ cord-353298-vr5hnzp8 220 11 experiments experiment NNS cord-353298-vr5hnzp8 220 12 , , , cord-353298-vr5hnzp8 220 13 the the DT cord-353298-vr5hnzp8 220 14 ratio ratio NN cord-353298-vr5hnzp8 220 15 of of IN cord-353298-vr5hnzp8 220 16 type type NN cord-353298-vr5hnzp8 220 17 2 2 CD cord-353298-vr5hnzp8 220 18 astrocytes astrocyte NNS cord-353298-vr5hnzp8 220 19 to to IN cord-353298-vr5hnzp8 220 20 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 220 21 was be VBD cord-353298-vr5hnzp8 220 22 compared compare VBN cord-353298-vr5hnzp8 220 23 in in IN cord-353298-vr5hnzp8 220 24 three three CD cord-353298-vr5hnzp8 220 25 similar similar JJ cord-353298-vr5hnzp8 220 26 experiments experiment NNS cord-353298-vr5hnzp8 220 27 of of IN cord-353298-vr5hnzp8 220 28 cultures culture NNS cord-353298-vr5hnzp8 220 29 grown grow VBN cord-353298-vr5hnzp8 220 30 without without IN cord-353298-vr5hnzp8 220 31 exogenous exogenous JJ cord-353298-vr5hnzp8 220 32 growth growth NN cord-353298-vr5hnzp8 220 33 factors factor NNS cord-353298-vr5hnzp8 220 34 . . . cord-353298-vr5hnzp8 221 1 The the DT cord-353298-vr5hnzp8 221 2 asterisks asterisk NNS cord-353298-vr5hnzp8 221 3 denote denote VBP cord-353298-vr5hnzp8 221 4 values value NNS cord-353298-vr5hnzp8 221 5 which which WDT cord-353298-vr5hnzp8 221 6 fall fall VBP cord-353298-vr5hnzp8 221 7 outside outside RB cord-353298-vr5hnzp8 221 8 of of IN cord-353298-vr5hnzp8 221 9 a a DT cord-353298-vr5hnzp8 221 10 95 95 CD cord-353298-vr5hnzp8 221 11 % % NN cord-353298-vr5hnzp8 221 12 confidence confidence NN cord-353298-vr5hnzp8 221 13 interval interval NN cord-353298-vr5hnzp8 221 14 of of IN cord-353298-vr5hnzp8 221 15 the the DT cord-353298-vr5hnzp8 221 16 expected expect VBN cord-353298-vr5hnzp8 221 17 variability variability NN cord-353298-vr5hnzp8 221 18 between between IN cord-353298-vr5hnzp8 221 19 experiments experiment NNS cord-353298-vr5hnzp8 221 20 for for IN cord-353298-vr5hnzp8 221 21 cultures culture NNS cord-353298-vr5hnzp8 221 22 grown grow VBN cord-353298-vr5hnzp8 221 23 without without IN cord-353298-vr5hnzp8 221 24 exogenous exogenous JJ cord-353298-vr5hnzp8 221 25 growth growth NN cord-353298-vr5hnzp8 221 26 factors factor NNS cord-353298-vr5hnzp8 221 27 . . . cord-353298-vr5hnzp8 222 1 Fig Fig NNP cord-353298-vr5hnzp8 222 2 . . NNP cord-353298-vr5hnzp8 222 3 1 1 CD cord-353298-vr5hnzp8 222 4 , , , cord-353298-vr5hnzp8 222 5 A a NN cord-353298-vr5hnzp8 222 6 and and CC cord-353298-vr5hnzp8 222 7 B b NN cord-353298-vr5hnzp8 222 8 ) ) -RRB- cord-353298-vr5hnzp8 222 9 . . . cord-353298-vr5hnzp8 223 1 Each each DT cord-353298-vr5hnzp8 223 2 value value NN cord-353298-vr5hnzp8 223 3 is be VBZ cord-353298-vr5hnzp8 223 4 the the DT cord-353298-vr5hnzp8 223 5 percentage percentage NN cord-353298-vr5hnzp8 223 6 ( ( -LRB- cord-353298-vr5hnzp8 223 7 + + SYM cord-353298-vr5hnzp8 223 8 SEM SEM NNP cord-353298-vr5hnzp8 223 9 ) ) -RRB- cord-353298-vr5hnzp8 223 10 of of IN cord-353298-vr5hnzp8 223 11 total total JJ cord-353298-vr5hnzp8 223 12 O-2A O-2A NNP cord-353298-vr5hnzp8 223 13 lineage lineage NN cord-353298-vr5hnzp8 223 14 cells cell NNS cord-353298-vr5hnzp8 223 15 ( ( -LRB- cord-353298-vr5hnzp8 223 16 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 223 17 , , , cord-353298-vr5hnzp8 223 18 type type NN cord-353298-vr5hnzp8 223 19 2 2 CD cord-353298-vr5hnzp8 223 20 astrocytes astrocyte NNS cord-353298-vr5hnzp8 223 21 , , , cord-353298-vr5hnzp8 223 22 O-2A O-2A NNP cord-353298-vr5hnzp8 223 23 progenitors progenitor NNS cord-353298-vr5hnzp8 223 24 , , , cord-353298-vr5hnzp8 223 25 and and CC cord-353298-vr5hnzp8 223 26 mixed mixed JJ cord-353298-vr5hnzp8 223 27 phenotype phenotype NN cord-353298-vr5hnzp8 223 28 cells cell NNS cord-353298-vr5hnzp8 223 29 combined combine VBN cord-353298-vr5hnzp8 223 30 ) ) -RRB- cord-353298-vr5hnzp8 223 31 which which WDT cord-353298-vr5hnzp8 223 32 were be VBD cord-353298-vr5hnzp8 223 33 [ [ -LRB- cord-353298-vr5hnzp8 223 34 ~Hlthymidine ~hlthymidine CD cord-353298-vr5hnzp8 223 35 - - HYPH cord-353298-vr5hnzp8 223 36 labeled label VBN cord-353298-vr5hnzp8 223 37 ( ( -LRB- cord-353298-vr5hnzp8 223 38 greater great JJR cord-353298-vr5hnzp8 223 39 than than IN cord-353298-vr5hnzp8 223 40 10 10 CD cord-353298-vr5hnzp8 223 41 autoradiographic autoradiographic JJ cord-353298-vr5hnzp8 223 42 silver silver JJ cord-353298-vr5hnzp8 223 43 grains grain NNS cord-353298-vr5hnzp8 223 44 localized localize VBN cord-353298-vr5hnzp8 223 45 over over IN cord-353298-vr5hnzp8 223 46 each each DT cord-353298-vr5hnzp8 223 47 nucleus nucleus NN cord-353298-vr5hnzp8 223 48 ) ) -RRB- cord-353298-vr5hnzp8 223 49 and and CC cord-353298-vr5hnzp8 223 50 represents represent VBZ cord-353298-vr5hnzp8 223 51 the the DT cord-353298-vr5hnzp8 223 52 average average NN cord-353298-vr5hnzp8 223 53 of of IN cord-353298-vr5hnzp8 223 54 2 2 CD cord-353298-vr5hnzp8 223 55 - - SYM cord-353298-vr5hnzp8 223 56 3 3 CD cord-353298-vr5hnzp8 223 57 dishes dish NNS cord-353298-vr5hnzp8 223 58 . . . cord-353298-vr5hnzp8 224 1 Significance significance NN cord-353298-vr5hnzp8 224 2 values value NNS cord-353298-vr5hnzp8 224 3 were be VBD cord-353298-vr5hnzp8 224 4 determined determine VBN cord-353298-vr5hnzp8 224 5 using use VBG cord-353298-vr5hnzp8 224 6 the the DT cord-353298-vr5hnzp8 224 7 two two CD cord-353298-vr5hnzp8 224 8 - - HYPH cord-353298-vr5hnzp8 224 9 tailed tailed JJ cord-353298-vr5hnzp8 224 10 paired pair VBN cord-353298-vr5hnzp8 224 11 t t NN cord-353298-vr5hnzp8 224 12 test test NN cord-353298-vr5hnzp8 224 13 . . . cord-353298-vr5hnzp8 225 1 Studies study NNS cord-353298-vr5hnzp8 225 2 of of IN cord-353298-vr5hnzp8 225 3 neonatal neonatal JJ cord-353298-vr5hnzp8 225 4 CNS CNS NNP cord-353298-vr5hnzp8 225 5 tissue tissue NN cord-353298-vr5hnzp8 225 6 have have VBP cord-353298-vr5hnzp8 225 7 shown show VBN cord-353298-vr5hnzp8 225 8 that that IN cord-353298-vr5hnzp8 225 9 the the DT cord-353298-vr5hnzp8 225 10 growth growth NN cord-353298-vr5hnzp8 225 11 and and CC cord-353298-vr5hnzp8 225 12 differentiation differentiation NN cord-353298-vr5hnzp8 225 13 of of IN cord-353298-vr5hnzp8 225 14 O-2A O-2A NNP cord-353298-vr5hnzp8 225 15 lineage lineage NN cord-353298-vr5hnzp8 225 16 cells cell NNS cord-353298-vr5hnzp8 225 17 can can MD cord-353298-vr5hnzp8 225 18 be be VB cord-353298-vr5hnzp8 225 19 influenced influence VBN cord-353298-vr5hnzp8 225 20 in in IN cord-353298-vr5hnzp8 225 21 vitro vitro FW cord-353298-vr5hnzp8 225 22 by by IN cord-353298-vr5hnzp8 225 23 several several JJ cord-353298-vr5hnzp8 225 24 polypeptide polypeptide NN cord-353298-vr5hnzp8 225 25 growth growth NN cord-353298-vr5hnzp8 225 26 factors factor NNS cord-353298-vr5hnzp8 225 27 , , , cord-353298-vr5hnzp8 225 28 which which WDT cord-353298-vr5hnzp8 225 29 are be VBP cord-353298-vr5hnzp8 225 30 synthesized synthesize VBN cord-353298-vr5hnzp8 225 31 in in IN cord-353298-vr5hnzp8 225 32 the the DT cord-353298-vr5hnzp8 225 33 brain brain NN cord-353298-vr5hnzp8 225 34 ( ( -LRB- cord-353298-vr5hnzp8 225 35 for for IN cord-353298-vr5hnzp8 225 36 review review NN cord-353298-vr5hnzp8 225 37 , , , cord-353298-vr5hnzp8 225 38 see see VB cord-353298-vr5hnzp8 225 39 Raft Raft NNP cord-353298-vr5hnzp8 225 40 , , , cord-353298-vr5hnzp8 225 41 1989 1989 CD cord-353298-vr5hnzp8 225 42 ; ; : cord-353298-vr5hnzp8 225 43 Dubois Dubois NNP cord-353298-vr5hnzp8 225 44 - - HYPH cord-353298-vr5hnzp8 225 45 Dalcq Dalcq NNP cord-353298-vr5hnzp8 225 46 and and CC cord-353298-vr5hnzp8 225 47 Armstrong Armstrong NNP cord-353298-vr5hnzp8 225 48 , , , cord-353298-vr5hnzp8 225 49 1990 1990 CD cord-353298-vr5hnzp8 225 50 ) ) -RRB- cord-353298-vr5hnzp8 225 51 . . . cord-353298-vr5hnzp8 226 1 PDGF PDGF NNP cord-353298-vr5hnzp8 226 2 stimulates stimulate VBZ cord-353298-vr5hnzp8 226 3 the the DT cord-353298-vr5hnzp8 226 4 proliferation proliferation NN cord-353298-vr5hnzp8 226 5 of of IN cord-353298-vr5hnzp8 226 6 O-2A O-2A NNP cord-353298-vr5hnzp8 226 7 progenitor progenitor NN cord-353298-vr5hnzp8 226 8 cells cell NNS cord-353298-vr5hnzp8 226 9 , , , cord-353298-vr5hnzp8 226 10 which which WDT cord-353298-vr5hnzp8 226 11 prevents prevent VBZ cord-353298-vr5hnzp8 226 12 premature premature JJ cord-353298-vr5hnzp8 226 13 differentiation differentiation NN cord-353298-vr5hnzp8 226 14 in in IN cord-353298-vr5hnzp8 226 15 vitro vitro FW cord-353298-vr5hnzp8 226 16 Raff Raff NNP cord-353298-vr5hnzp8 226 17 et et FW cord-353298-vr5hnzp8 226 18 al al NNP cord-353298-vr5hnzp8 226 19 . . NNP cord-353298-vr5hnzp8 226 20 , , , cord-353298-vr5hnzp8 226 21 1988 1988 CD cord-353298-vr5hnzp8 226 22 ) ) -RRB- cord-353298-vr5hnzp8 226 23 . . . cord-353298-vr5hnzp8 227 1 Figure figure NN cord-353298-vr5hnzp8 227 2 11 11 CD cord-353298-vr5hnzp8 227 3 . . . cord-353298-vr5hnzp8 228 1 A a DT cord-353298-vr5hnzp8 228 2 type type NN cord-353298-vr5hnzp8 228 3 2 2 CD cord-353298-vr5hnzp8 228 4 astroeyte astroeyte NN cord-353298-vr5hnzp8 228 5 cultured culture VBN cord-353298-vr5hnzp8 228 6 from from IN cord-353298-vr5hnzp8 228 7 demyelinated demyelinated JJ cord-353298-vr5hnzp8 228 8 tissue tissue NN cord-353298-vr5hnzp8 228 9 ( ( -LRB- cord-353298-vr5hnzp8 228 10 4 4 CD cord-353298-vr5hnzp8 228 11 wpi wpi NN cord-353298-vr5hnzp8 228 12 ) ) -RRB- cord-353298-vr5hnzp8 228 13 and and CC cord-353298-vr5hnzp8 228 14 processed process VBN cord-353298-vr5hnzp8 228 15 as as IN cord-353298-vr5hnzp8 228 16 described describe VBN cord-353298-vr5hnzp8 228 17 in in IN cord-353298-vr5hnzp8 228 18 Fig Fig NNP cord-353298-vr5hnzp8 228 19 . . . cord-353298-vr5hnzp8 229 1 10 10 CD cord-353298-vr5hnzp8 229 2 is be VBZ cord-353298-vr5hnzp8 229 3 identified identify VBN cord-353298-vr5hnzp8 229 4 by by IN cord-353298-vr5hnzp8 229 5 the the DT cord-353298-vr5hnzp8 229 6 presence presence NN cord-353298-vr5hnzp8 229 7 of of IN cord-353298-vr5hnzp8 229 8 surface surface NN cord-353298-vr5hnzp8 229 9 staining stain VBG cord-353298-vr5hnzp8 229 10 with with IN cord-353298-vr5hnzp8 229 11 04 04 CD cord-353298-vr5hnzp8 229 12 ( ( -LRB- cord-353298-vr5hnzp8 229 13 A a NN cord-353298-vr5hnzp8 229 14 ; ; , cord-353298-vr5hnzp8 229 15 rhodamine rhodamine JJ cord-353298-vr5hnzp8 229 16 optics optic NNS cord-353298-vr5hnzp8 229 17 ) ) -RRB- cord-353298-vr5hnzp8 229 18 , , , cord-353298-vr5hnzp8 229 19 intracellular intracellular JJ cord-353298-vr5hnzp8 229 20 expression expression NN cord-353298-vr5hnzp8 229 21 of of IN cord-353298-vr5hnzp8 229 22 GFAP GFAP NNP cord-353298-vr5hnzp8 229 23 ( ( -LRB- cord-353298-vr5hnzp8 229 24 B b NN cord-353298-vr5hnzp8 229 25 ; ; : cord-353298-vr5hnzp8 229 26 coumarin coumarin NN cord-353298-vr5hnzp8 229 27 optics optics NNP cord-353298-vr5hnzp8 229 28 ) ) -RRB- cord-353298-vr5hnzp8 229 29 and and CC cord-353298-vr5hnzp8 229 30 the the DT cord-353298-vr5hnzp8 229 31 absence absence NN cord-353298-vr5hnzp8 229 32 of of IN cord-353298-vr5hnzp8 229 33 labeling label VBG cord-353298-vr5hnzp8 229 34 with with IN cord-353298-vr5hnzp8 229 35 GC GC NNP cord-353298-vr5hnzp8 229 36 antibody antibody NN cord-353298-vr5hnzp8 229 37 ( ( -LRB- cord-353298-vr5hnzp8 229 38 C C NNP cord-353298-vr5hnzp8 229 39 ; ; : cord-353298-vr5hnzp8 229 40 fluoreseein fluoreseein NNP cord-353298-vr5hnzp8 229 41 optics optics NNP cord-353298-vr5hnzp8 229 42 ) ) -RRB- cord-353298-vr5hnzp8 229 43 . . . cord-353298-vr5hnzp8 230 1 The the DT cord-353298-vr5hnzp8 230 2 cluster cluster NN cord-353298-vr5hnzp8 230 3 of of IN cord-353298-vr5hnzp8 230 4 silver silver JJ cord-353298-vr5hnzp8 230 5 grains grain NNS cord-353298-vr5hnzp8 230 6 over over IN cord-353298-vr5hnzp8 230 7 the the DT cord-353298-vr5hnzp8 230 8 nucleus nucleus NN cord-353298-vr5hnzp8 230 9 ( ( -LRB- cord-353298-vr5hnzp8 230 10 D D NNP cord-353298-vr5hnzp8 230 11 , , , cord-353298-vr5hnzp8 230 12 arrow arrow NN cord-353298-vr5hnzp8 230 13 ) ) -RRB- cord-353298-vr5hnzp8 230 14 indicates indicate VBZ cord-353298-vr5hnzp8 230 15 that that IN cord-353298-vr5hnzp8 230 16 this this DT cord-353298-vr5hnzp8 230 17 cell cell NN cord-353298-vr5hnzp8 230 18 incorporated incorporate VBD cord-353298-vr5hnzp8 230 19 [ [ -LRB- cord-353298-vr5hnzp8 230 20 3H]thymidine 3h]thymidine CD cord-353298-vr5hnzp8 230 21 during during IN cord-353298-vr5hnzp8 230 22 the the DT cord-353298-vr5hnzp8 230 23 20-h 20-h CD cord-353298-vr5hnzp8 230 24 in in FW cord-353298-vr5hnzp8 230 25 vitro vitro FW cord-353298-vr5hnzp8 230 26 pulse pulse NN cord-353298-vr5hnzp8 230 27 . . . cord-353298-vr5hnzp8 231 1 ( ( -LRB- cord-353298-vr5hnzp8 231 2 E e NN cord-353298-vr5hnzp8 231 3 ) ) -RRB- cord-353298-vr5hnzp8 231 4 Phase phase NN cord-353298-vr5hnzp8 231 5 contrast contrast NN cord-353298-vr5hnzp8 231 6 showing show VBG cord-353298-vr5hnzp8 231 7 the the DT cord-353298-vr5hnzp8 231 8 cell cell NN cord-353298-vr5hnzp8 231 9 processes process NNS cord-353298-vr5hnzp8 231 10 . . . cord-353298-vr5hnzp8 232 1 Bar bar NN cord-353298-vr5hnzp8 232 2 , , , cord-353298-vr5hnzp8 232 3 50 50 CD cord-353298-vr5hnzp8 232 4 # # NN cord-353298-vr5hnzp8 232 5 m. m. NN cord-353298-vr5hnzp8 232 6 FGF FGF NNP cord-353298-vr5hnzp8 232 7 is be VBZ cord-353298-vr5hnzp8 232 8 also also RB cord-353298-vr5hnzp8 232 9 mitogenic mitogenic NNP cord-353298-vr5hnzp8 232 10 for for IN cord-353298-vr5hnzp8 232 11 O-2A O-2A NNP cord-353298-vr5hnzp8 232 12 lineage lineage NN cord-353298-vr5hnzp8 232 13 cells cell NNS cord-353298-vr5hnzp8 232 14 ( ( -LRB- cord-353298-vr5hnzp8 232 15 Eccleston Eccleston NNP cord-353298-vr5hnzp8 232 16 and and CC cord-353298-vr5hnzp8 232 17 Silberberg Silberberg NNP cord-353298-vr5hnzp8 232 18 , , , cord-353298-vr5hnzp8 232 19 1985 1985 CD cord-353298-vr5hnzp8 232 20 ; ; : cord-353298-vr5hnzp8 232 21 Noble Noble NNP cord-353298-vr5hnzp8 232 22 et et NNP cord-353298-vr5hnzp8 232 23 al al NNP cord-353298-vr5hnzp8 232 24 . . NNP cord-353298-vr5hnzp8 232 25 , , , cord-353298-vr5hnzp8 232 26 1988 1988 CD cord-353298-vr5hnzp8 232 27 ; ; : cord-353298-vr5hnzp8 232 28 Besnard Besnard NNP cord-353298-vr5hnzp8 232 29 et et NNP cord-353298-vr5hnzp8 232 30 al al NNP cord-353298-vr5hnzp8 232 31 . . NNP cord-353298-vr5hnzp8 232 32 , , , cord-353298-vr5hnzp8 232 33 1989 1989 CD cord-353298-vr5hnzp8 232 34 ) ) -RRB- cord-353298-vr5hnzp8 232 35 . . . cord-353298-vr5hnzp8 233 1 Both both DT cord-353298-vr5hnzp8 233 2 FGF FGF NNP cord-353298-vr5hnzp8 233 3 and and CC cord-353298-vr5hnzp8 233 4 epidermal epidermal JJ cord-353298-vr5hnzp8 233 5 growth growth NN cord-353298-vr5hnzp8 233 6 factor factor NN cord-353298-vr5hnzp8 233 7 inhibit inhibit VBP cord-353298-vr5hnzp8 233 8 expression expression NN cord-353298-vr5hnzp8 233 9 of of IN cord-353298-vr5hnzp8 233 10 myelin myelin NN cord-353298-vr5hnzp8 233 11 components component NNS cord-353298-vr5hnzp8 233 12 ( ( -LRB- cord-353298-vr5hnzp8 233 13 Sheng Sheng NNP cord-353298-vr5hnzp8 233 14 et et FW cord-353298-vr5hnzp8 233 15 al al NNP cord-353298-vr5hnzp8 233 16 . . NNP cord-353298-vr5hnzp8 233 17 , , , cord-353298-vr5hnzp8 233 18 1989 1989 CD cord-353298-vr5hnzp8 233 19 ) ) -RRB- cord-353298-vr5hnzp8 233 20 . . . cord-353298-vr5hnzp8 234 1 IGF IGF NNP cord-353298-vr5hnzp8 234 2 - - : cord-353298-vr5hnzp8 234 3 I -PRON- PRP cord-353298-vr5hnzp8 234 4 promotes promote VBZ cord-353298-vr5hnzp8 234 5 proliferation proliferation NN cord-353298-vr5hnzp8 234 6 of of IN cord-353298-vr5hnzp8 234 7 O-2A O-2A NNP cord-353298-vr5hnzp8 234 8 lineage lineage NN cord-353298-vr5hnzp8 234 9 cells cell NNS cord-353298-vr5hnzp8 234 10 while while IN cord-353298-vr5hnzp8 234 11 also also RB cord-353298-vr5hnzp8 234 12 inducing induce VBG cord-353298-vr5hnzp8 234 13 precursor precursor NN cord-353298-vr5hnzp8 234 14 cells cell NNS cord-353298-vr5hnzp8 234 15 to to TO cord-353298-vr5hnzp8 234 16 develop develop VB cord-353298-vr5hnzp8 234 17 into into IN cord-353298-vr5hnzp8 234 18 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 234 19 ( ( -LRB- cord-353298-vr5hnzp8 234 20 McMorris McMorris NNP cord-353298-vr5hnzp8 234 21 and and CC cord-353298-vr5hnzp8 234 22 Dubois Dubois NNP cord-353298-vr5hnzp8 234 23 - - HYPH cord-353298-vr5hnzp8 234 24 Daicq Daicq NNP cord-353298-vr5hnzp8 234 25 , , , cord-353298-vr5hnzp8 234 26 1988 1988 CD cord-353298-vr5hnzp8 234 27 ) ) -RRB- cord-353298-vr5hnzp8 234 28 . . . cord-353298-vr5hnzp8 235 1 A a DT cord-353298-vr5hnzp8 235 2 protein protein NN cord-353298-vr5hnzp8 235 3 closely closely RB cord-353298-vr5hnzp8 235 4 related relate VBN cord-353298-vr5hnzp8 235 5 to to IN cord-353298-vr5hnzp8 235 6 ciliary ciliary NN cord-353298-vr5hnzp8 235 7 neurotrophic neurotrophic NN cord-353298-vr5hnzp8 235 8 factor factor NN cord-353298-vr5hnzp8 235 9 is be VBZ cord-353298-vr5hnzp8 235 10 present present JJ cord-353298-vr5hnzp8 235 11 in in IN cord-353298-vr5hnzp8 235 12 developing develop VBG cord-353298-vr5hnzp8 235 13 optic optic JJ cord-353298-vr5hnzp8 235 14 nerve nerve NN cord-353298-vr5hnzp8 235 15 and and CC cord-353298-vr5hnzp8 235 16 induces induce VBZ cord-353298-vr5hnzp8 235 17 transient transient JJ cord-353298-vr5hnzp8 235 18 expression expression NN cord-353298-vr5hnzp8 235 19 of of IN cord-353298-vr5hnzp8 235 20 GFAP GFAP NNP cord-353298-vr5hnzp8 235 21 in in IN cord-353298-vr5hnzp8 235 22 O-2A O-2A NNP cord-353298-vr5hnzp8 235 23 progenitor progenitor NN cord-353298-vr5hnzp8 235 24 cells cell NNS cord-353298-vr5hnzp8 235 25 in in IN cord-353298-vr5hnzp8 235 26 vitro vitro FW cord-353298-vr5hnzp8 236 1 Lillien Lillien NNP cord-353298-vr5hnzp8 236 2 et et NNP cord-353298-vr5hnzp8 236 3 al al NNP cord-353298-vr5hnzp8 236 4 . . NNP cord-353298-vr5hnzp8 236 5 , , , cord-353298-vr5hnzp8 236 6 1988 1988 CD cord-353298-vr5hnzp8 236 7 ) ) -RRB- cord-353298-vr5hnzp8 236 8 . . . cord-353298-vr5hnzp8 237 1 Whether whether IN cord-353298-vr5hnzp8 237 2 the the DT cord-353298-vr5hnzp8 237 3 growth growth NN cord-353298-vr5hnzp8 237 4 factors factor NNS cord-353298-vr5hnzp8 237 5 mentioned mention VBN cord-353298-vr5hnzp8 237 6 above above RB cord-353298-vr5hnzp8 237 7 have have VBP cord-353298-vr5hnzp8 237 8 an an DT cord-353298-vr5hnzp8 237 9 effect effect NN cord-353298-vr5hnzp8 237 10 on on IN cord-353298-vr5hnzp8 237 11 O-2A O-2A NNP cord-353298-vr5hnzp8 237 12 lineage lineage NN cord-353298-vr5hnzp8 237 13 cells cell NNS cord-353298-vr5hnzp8 237 14 derived derive VBN cord-353298-vr5hnzp8 237 15 from from IN cord-353298-vr5hnzp8 237 16 adult adult NN cord-353298-vr5hnzp8 237 17 CNS cns JJ cord-353298-vr5hnzp8 237 18 tissue tissue NN cord-353298-vr5hnzp8 237 19 is be VBZ cord-353298-vr5hnzp8 237 20 not not RB cord-353298-vr5hnzp8 237 21 yet yet RB cord-353298-vr5hnzp8 237 22 clear clear JJ cord-353298-vr5hnzp8 237 23 . . . cord-353298-vr5hnzp8 238 1 Human human JJ cord-353298-vr5hnzp8 238 2 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 238 3 isolated isolate VBN cord-353298-vr5hnzp8 238 4 from from IN cord-353298-vr5hnzp8 238 5 normal normal JJ cord-353298-vr5hnzp8 238 6 adult adult NN cord-353298-vr5hnzp8 238 7 brain brain NN cord-353298-vr5hnzp8 238 8 do do VBP cord-353298-vr5hnzp8 238 9 not not RB cord-353298-vr5hnzp8 238 10 proliferate proliferate VB cord-353298-vr5hnzp8 238 11 in in IN cord-353298-vr5hnzp8 238 12 response response NN cord-353298-vr5hnzp8 238 13 to to IN cord-353298-vr5hnzp8 238 14 treatment treatment NN cord-353298-vr5hnzp8 238 15 with with IN cord-353298-vr5hnzp8 238 16 several several JJ cord-353298-vr5hnzp8 238 17 growth growth NN cord-353298-vr5hnzp8 238 18 factors factor NNS cord-353298-vr5hnzp8 238 19 , , , cord-353298-vr5hnzp8 238 20 including include VBG cord-353298-vr5hnzp8 238 21 PDGF PDGF NNP cord-353298-vr5hnzp8 238 22 , , , cord-353298-vr5hnzp8 238 23 FGF FGF NNP cord-353298-vr5hnzp8 238 24 , , , cord-353298-vr5hnzp8 238 25 epidermal epidermal JJ cord-353298-vr5hnzp8 238 26 growth growth NN cord-353298-vr5hnzp8 238 27 factor factor NN cord-353298-vr5hnzp8 238 28 , , , cord-353298-vr5hnzp8 238 29 and and CC cord-353298-vr5hnzp8 238 30 interleukin interleukin NN cord-353298-vr5hnzp8 238 31 2 2 CD cord-353298-vr5hnzp8 239 1 ( ( -LRB- cord-353298-vr5hnzp8 239 2 Yong Yong NNP cord-353298-vr5hnzp8 239 3 et et NNP cord-353298-vr5hnzp8 239 4 al al NNP cord-353298-vr5hnzp8 239 5 . . NNP cord-353298-vr5hnzp8 239 6 , , , cord-353298-vr5hnzp8 239 7 1988 1988 CD cord-353298-vr5hnzp8 239 8 ) ) -RRB- cord-353298-vr5hnzp8 239 9 . . . cord-353298-vr5hnzp8 240 1 Similarly similarly RB cord-353298-vr5hnzp8 240 2 , , , cord-353298-vr5hnzp8 240 3 in in IN cord-353298-vr5hnzp8 240 4 the the DT cord-353298-vr5hnzp8 240 5 present present JJ cord-353298-vr5hnzp8 240 6 study study NN cord-353298-vr5hnzp8 240 7 we -PRON- PRP cord-353298-vr5hnzp8 240 8 found find VBD cord-353298-vr5hnzp8 240 9 that that IN cord-353298-vr5hnzp8 240 10 PDGF PDGF NNP cord-353298-vr5hnzp8 240 11 , , , cord-353298-vr5hnzp8 240 12 bFGF bfgf NN cord-353298-vr5hnzp8 240 13 , , , cord-353298-vr5hnzp8 240 14 or or CC cord-353298-vr5hnzp8 240 15 IGF IGF NNP cord-353298-vr5hnzp8 240 16 - - : cord-353298-vr5hnzp8 240 17 I -PRON- PRP cord-353298-vr5hnzp8 240 18 did do VBD cord-353298-vr5hnzp8 240 19 not not RB cord-353298-vr5hnzp8 240 20 induce induce VB cord-353298-vr5hnzp8 240 21 mitosis mitosis NN cord-353298-vr5hnzp8 240 22 of of IN cord-353298-vr5hnzp8 240 23 O-2A O-2A NNP cord-353298-vr5hnzp8 240 24 lineage lineage NN cord-353298-vr5hnzp8 240 25 cells cell NNS cord-353298-vr5hnzp8 240 26 cultured culture VBN cord-353298-vr5hnzp8 240 27 from from IN cord-353298-vr5hnzp8 240 28 adult adult NN cord-353298-vr5hnzp8 240 29 mice mouse NNS cord-353298-vr5hnzp8 240 30 , , , cord-353298-vr5hnzp8 240 31 as as IN cord-353298-vr5hnzp8 240 32 assayed assay VBN cord-353298-vr5hnzp8 240 33 by by IN cord-353298-vr5hnzp8 240 34 [ [ -LRB- cord-353298-vr5hnzp8 240 35 3H]thymidine 3h]thymidine CD cord-353298-vr5hnzp8 240 36 incorporation incorporation NN cord-353298-vr5hnzp8 240 37 . . . cord-353298-vr5hnzp8 241 1 However however RB cord-353298-vr5hnzp8 241 2 , , , cord-353298-vr5hnzp8 241 3 a a DT cord-353298-vr5hnzp8 241 4 factor factor NN cord-353298-vr5hnzp8 241 5 secreted secrete VBN cord-353298-vr5hnzp8 241 6 by by IN cord-353298-vr5hnzp8 241 7 B104 B104 NNP cord-353298-vr5hnzp8 241 8 neuroblastoma neuroblastoma NN cord-353298-vr5hnzp8 241 9 cells cell NNS cord-353298-vr5hnzp8 241 10 is be VBZ cord-353298-vr5hnzp8 241 11 mitogenic mitogenic JJ cord-353298-vr5hnzp8 241 12 for for IN cord-353298-vr5hnzp8 241 13 O-2A O-2A NNP cord-353298-vr5hnzp8 241 14 progenitors progenitor NNS cord-353298-vr5hnzp8 241 15 and and CC cord-353298-vr5hnzp8 241 16 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 241 17 cultured culture VBN cord-353298-vr5hnzp8 241 18 from from IN cord-353298-vr5hnzp8 241 19 adult adult NN cord-353298-vr5hnzp8 241 20 rat rat NN cord-353298-vr5hnzp8 241 21 brain brain NN cord-353298-vr5hnzp8 241 22 ( ( -LRB- cord-353298-vr5hnzp8 241 23 Hunter Hunter NNP cord-353298-vr5hnzp8 241 24 et et NNP cord-353298-vr5hnzp8 241 25 al al NNP cord-353298-vr5hnzp8 241 26 . . NNP cord-353298-vr5hnzp8 241 27 , , , cord-353298-vr5hnzp8 241 28 1988 1988 CD cord-353298-vr5hnzp8 241 29 ) ) -RRB- cord-353298-vr5hnzp8 241 30 . . . cord-353298-vr5hnzp8 242 1 Thus thus RB cord-353298-vr5hnzp8 242 2 , , , cord-353298-vr5hnzp8 242 3 normal normal JJ cord-353298-vr5hnzp8 242 4 adult adult NN cord-353298-vr5hnzp8 242 5 O-2A O-2A NNP cord-353298-vr5hnzp8 242 6 lineage lineage NN cord-353298-vr5hnzp8 242 7 cells cell NNS cord-353298-vr5hnzp8 242 8 are be VBP cord-353298-vr5hnzp8 242 9 capable capable JJ cord-353298-vr5hnzp8 242 10 of of IN cord-353298-vr5hnzp8 242 11 proliferating proliferate VBG cord-353298-vr5hnzp8 242 12 when when WRB cord-353298-vr5hnzp8 242 13 exposed expose VBN cord-353298-vr5hnzp8 242 14 to to IN cord-353298-vr5hnzp8 242 15 an an DT cord-353298-vr5hnzp8 242 16 adequate adequate JJ cord-353298-vr5hnzp8 242 17 stimulus stimulus NN cord-353298-vr5hnzp8 242 18 . . . cord-353298-vr5hnzp8 243 1 Such such JJ cord-353298-vr5hnzp8 243 2 a a DT cord-353298-vr5hnzp8 243 3 stimulus stimulus NN cord-353298-vr5hnzp8 243 4 could could MD cord-353298-vr5hnzp8 243 5 be be VB cord-353298-vr5hnzp8 243 6 a a DT cord-353298-vr5hnzp8 243 7 factor factor NN cord-353298-vr5hnzp8 243 8 ( ( -LRB- cord-353298-vr5hnzp8 243 9 or or CC cord-353298-vr5hnzp8 243 10 factors factor NNS cord-353298-vr5hnzp8 243 11 ) ) -RRB- cord-353298-vr5hnzp8 243 12 released release VBN cord-353298-vr5hnzp8 243 13 in in IN cord-353298-vr5hnzp8 243 14 the the DT cord-353298-vr5hnzp8 243 15 CNS CNS NNP cord-353298-vr5hnzp8 243 16 during during IN cord-353298-vr5hnzp8 243 17 demyelination demyelination NN cord-353298-vr5hnzp8 243 18 since since IN cord-353298-vr5hnzp8 243 19 O-2A O-2A NNP cord-353298-vr5hnzp8 243 20 lineage lineage NN cord-353298-vr5hnzp8 243 21 cells cell NNS cord-353298-vr5hnzp8 243 22 in in IN cord-353298-vr5hnzp8 243 23 the the DT cord-353298-vr5hnzp8 243 24 spinal spinal JJ cord-353298-vr5hnzp8 243 25 cord cord NN cord-353298-vr5hnzp8 243 26 of of IN cord-353298-vr5hnzp8 243 27 MHV MHV NNP cord-353298-vr5hnzp8 243 28 - - HYPH cord-353298-vr5hnzp8 243 29 A59 A59 NNP cord-353298-vr5hnzp8 243 30 infected infected JJ cord-353298-vr5hnzp8 243 31 mice mouse NNS cord-353298-vr5hnzp8 243 32 showed show VBD cord-353298-vr5hnzp8 243 33 increased increase VBN cord-353298-vr5hnzp8 243 34 proliferation proliferation NN cord-353298-vr5hnzp8 243 35 both both CC cord-353298-vr5hnzp8 243 36 in in IN cord-353298-vr5hnzp8 243 37 vivo vivo NN cord-353298-vr5hnzp8 243 38 ( ( -LRB- cord-353298-vr5hnzp8 243 39 Godfraind Godfraind NNP cord-353298-vr5hnzp8 243 40 et et NNP cord-353298-vr5hnzp8 243 41 al al NNP cord-353298-vr5hnzp8 243 42 . . NNP cord-353298-vr5hnzp8 243 43 , , , cord-353298-vr5hnzp8 243 44 1989 1989 CD cord-353298-vr5hnzp8 243 45 ) ) -RRB- cord-353298-vr5hnzp8 243 46 and and CC cord-353298-vr5hnzp8 243 47 in in IN cord-353298-vr5hnzp8 243 48 vitro vitro FW cord-353298-vr5hnzp8 243 49 ( ( -LRB- cord-353298-vr5hnzp8 243 50 the the DT cord-353298-vr5hnzp8 243 51 present present JJ cord-353298-vr5hnzp8 243 52 data datum NNS cord-353298-vr5hnzp8 243 53 ) ) -RRB- cord-353298-vr5hnzp8 243 54 . . . cord-353298-vr5hnzp8 244 1 Interestingly interestingly RB cord-353298-vr5hnzp8 244 2 , , , cord-353298-vr5hnzp8 244 3 some some DT cord-353298-vr5hnzp8 244 4 growth growth NN cord-353298-vr5hnzp8 244 5 factors factor NNS cord-353298-vr5hnzp8 244 6 can can MD cord-353298-vr5hnzp8 244 7 influence influence VB cord-353298-vr5hnzp8 244 8 the the DT cord-353298-vr5hnzp8 244 9 antigenic antigenic JJ cord-353298-vr5hnzp8 244 10 phenotypes phenotype NNS cord-353298-vr5hnzp8 244 11 of of IN cord-353298-vr5hnzp8 244 12 O-2A O-2A NNP cord-353298-vr5hnzp8 244 13 lineage lineage NN cord-353298-vr5hnzp8 244 14 cells cell NNS cord-353298-vr5hnzp8 244 15 in in IN cord-353298-vr5hnzp8 244 16 our -PRON- PRP$ cord-353298-vr5hnzp8 244 17 cultures culture NNS cord-353298-vr5hnzp8 244 18 of of IN cord-353298-vr5hnzp8 244 19 demyelinating demyelinate VBG cord-353298-vr5hnzp8 244 20 / / SYM cord-353298-vr5hnzp8 244 21 remyelinating remyelinate VBG cord-353298-vr5hnzp8 244 22 CNS CNS NNP cord-353298-vr5hnzp8 244 23 . . . cord-353298-vr5hnzp8 245 1 Basic basic JJ cord-353298-vr5hnzp8 245 2 FGF FGF NNP cord-353298-vr5hnzp8 245 3 decreased decrease VBD cord-353298-vr5hnzp8 245 4 the the DT cord-353298-vr5hnzp8 245 5 percentage percentage NN cord-353298-vr5hnzp8 245 6 of of IN cord-353298-vr5hnzp8 245 7 O-2A O-2A NNP cord-353298-vr5hnzp8 245 8 lineage lineage NN cord-353298-vr5hnzp8 245 9 cells cell NNS cord-353298-vr5hnzp8 245 10 expressing express VBG cord-353298-vr5hnzp8 245 11 GC GC NNP cord-353298-vr5hnzp8 245 12 , , , cord-353298-vr5hnzp8 245 13 whereas whereas IN cord-353298-vr5hnzp8 245 14 IGF IGF NNP cord-353298-vr5hnzp8 245 15 - - HYPH cord-353298-vr5hnzp8 245 16 I -PRON- PRP cord-353298-vr5hnzp8 245 17 increased increase VBD cord-353298-vr5hnzp8 245 18 the the DT cord-353298-vr5hnzp8 245 19 proportion proportion NN cord-353298-vr5hnzp8 245 20 of of IN cord-353298-vr5hnzp8 245 21 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 245 22 relative relative JJ cord-353298-vr5hnzp8 245 23 to to IN cord-353298-vr5hnzp8 245 24 type type NN cord-353298-vr5hnzp8 245 25 2 2 CD cord-353298-vr5hnzp8 245 26 astrocytes astrocyte NNS cord-353298-vr5hnzp8 245 27 . . . cord-353298-vr5hnzp8 246 1 Thus thus RB cord-353298-vr5hnzp8 246 2 bFGF bfgf JJ cord-353298-vr5hnzp8 246 3 and and CC cord-353298-vr5hnzp8 246 4 IGF IGF NNP cord-353298-vr5hnzp8 246 5 - - : cord-353298-vr5hnzp8 246 6 I -PRON- PRP cord-353298-vr5hnzp8 246 7 might may MD cord-353298-vr5hnzp8 246 8 modulate modulate VB cord-353298-vr5hnzp8 246 9 phenotype phenotype NN cord-353298-vr5hnzp8 246 10 expression expression NN cord-353298-vr5hnzp8 246 11 in in IN cord-353298-vr5hnzp8 246 12 CNS CNS NNP cord-353298-vr5hnzp8 246 13 development development NN cord-353298-vr5hnzp8 246 14 and and CC cord-353298-vr5hnzp8 246 15 remyelination remyelination NN cord-353298-vr5hnzp8 246 16 . . . cord-353298-vr5hnzp8 247 1 Proliferation proliferation NN cord-353298-vr5hnzp8 247 2 of of IN cord-353298-vr5hnzp8 247 3 mature mature JJ cord-353298-vr5hnzp8 247 4 and and CC cord-353298-vr5hnzp8 247 5 immature immature JJ cord-353298-vr5hnzp8 247 6 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 247 7 in in IN cord-353298-vr5hnzp8 247 8 vivo vivo NN cord-353298-vr5hnzp8 247 9 has have VBZ cord-353298-vr5hnzp8 247 10 been be VBN cord-353298-vr5hnzp8 247 11 described describe VBN cord-353298-vr5hnzp8 247 12 in in IN cord-353298-vr5hnzp8 247 13 several several JJ cord-353298-vr5hnzp8 247 14 electron electron NN cord-353298-vr5hnzp8 247 15 microscopic microscopic JJ cord-353298-vr5hnzp8 247 16 and and CC cord-353298-vr5hnzp8 247 17 autoradiographic autoradiographic JJ cord-353298-vr5hnzp8 247 18 studies study NNS cord-353298-vr5hnzp8 247 19 of of IN cord-353298-vr5hnzp8 247 20 experimental experimental JJ cord-353298-vr5hnzp8 247 21 demyelination demyelination NN cord-353298-vr5hnzp8 247 22 in in IN cord-353298-vr5hnzp8 247 23 adult adult NN cord-353298-vr5hnzp8 247 24 CNS CNS NNP cord-353298-vr5hnzp8 247 25 ( ( -LRB- cord-353298-vr5hnzp8 247 26 Herndon Herndon NNP cord-353298-vr5hnzp8 247 27 et et NNP cord-353298-vr5hnzp8 247 28 al al NNP cord-353298-vr5hnzp8 247 29 . . NNP cord-353298-vr5hnzp8 247 30 , , , cord-353298-vr5hnzp8 247 31 1977 1977 CD cord-353298-vr5hnzp8 247 32 ; ; : cord-353298-vr5hnzp8 247 33 Ludwin Ludwin NNP cord-353298-vr5hnzp8 247 34 , , , cord-353298-vr5hnzp8 247 35 1979 1979 CD cord-353298-vr5hnzp8 247 36 ; ; : cord-353298-vr5hnzp8 247 37 Aranella Aranella NNP cord-353298-vr5hnzp8 247 38 and and CC cord-353298-vr5hnzp8 247 39 Herndon Herndon NNP cord-353298-vr5hnzp8 247 40 , , , cord-353298-vr5hnzp8 247 41 1984 1984 CD cord-353298-vr5hnzp8 247 42 ; ; : cord-353298-vr5hnzp8 247 43 Raine Raine NNP cord-353298-vr5hnzp8 247 44 et et NNP cord-353298-vr5hnzp8 247 45 al al NNP cord-353298-vr5hnzp8 247 46 . . NNP cord-353298-vr5hnzp8 247 47 , , , cord-353298-vr5hnzp8 247 48 1988 1988 CD cord-353298-vr5hnzp8 247 49 ) ) -RRB- cord-353298-vr5hnzp8 247 50 . . . cord-353298-vr5hnzp8 248 1 In in IN cord-353298-vr5hnzp8 248 2 our -PRON- PRP$ cord-353298-vr5hnzp8 248 3 in in IN cord-353298-vr5hnzp8 248 4 vivo vivo NN cord-353298-vr5hnzp8 248 5 studies study NNS cord-353298-vr5hnzp8 248 6 of of IN cord-353298-vr5hnzp8 248 7 remyelination remyelination NN cord-353298-vr5hnzp8 248 8 following follow VBG cord-353298-vr5hnzp8 248 9 coronavirus coronavirus NN cord-353298-vr5hnzp8 248 10 - - HYPH cord-353298-vr5hnzp8 248 11 induced induce VBN cord-353298-vr5hnzp8 248 12 demyelination demyelination NN cord-353298-vr5hnzp8 248 13 in in IN cord-353298-vr5hnzp8 248 14 mice mouse NNS cord-353298-vr5hnzp8 248 15 , , , cord-353298-vr5hnzp8 248 16 we -PRON- PRP cord-353298-vr5hnzp8 248 17 have have VBP cord-353298-vr5hnzp8 248 18 used use VBN cord-353298-vr5hnzp8 248 19 in in IN cord-353298-vr5hnzp8 248 20 situ situ NN cord-353298-vr5hnzp8 248 21 hybridization hybridization NN cord-353298-vr5hnzp8 248 22 and and CC cord-353298-vr5hnzp8 248 23 immunolabeling immunolabeling NN cord-353298-vr5hnzp8 248 24 techniques technique NNS cord-353298-vr5hnzp8 248 25 to to TO cord-353298-vr5hnzp8 248 26 analyze analyze VB cord-353298-vr5hnzp8 248 27 the the DT cord-353298-vr5hnzp8 248 28 expression expression NN cord-353298-vr5hnzp8 248 29 of of IN cord-353298-vr5hnzp8 248 30 myelin myelin JJ cord-353298-vr5hnzp8 248 31 genes gene NNS cord-353298-vr5hnzp8 248 32 and and CC cord-353298-vr5hnzp8 248 33 the the DT cord-353298-vr5hnzp8 248 34 presence presence NN cord-353298-vr5hnzp8 248 35 of of IN cord-353298-vr5hnzp8 248 36 cell cell NN cord-353298-vr5hnzp8 248 37 - - HYPH cord-353298-vr5hnzp8 248 38 type type NN cord-353298-vr5hnzp8 248 39 - - HYPH cord-353298-vr5hnzp8 248 40 specific specific JJ cord-353298-vr5hnzp8 248 41 antigens antigen NNS cord-353298-vr5hnzp8 248 42 in in IN cord-353298-vr5hnzp8 248 43 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 248 44 and and CC cord-353298-vr5hnzp8 248 45 their -PRON- PRP$ cord-353298-vr5hnzp8 248 46 precursors precursor NNS cord-353298-vr5hnzp8 248 47 ( ( -LRB- cord-353298-vr5hnzp8 248 48 Jordan Jordan NNP cord-353298-vr5hnzp8 248 49 et et NNP cord-353298-vr5hnzp8 248 50 al al NNP cord-353298-vr5hnzp8 248 51 . . NNP cord-353298-vr5hnzp8 248 52 , , , cord-353298-vr5hnzp8 248 53 1989 1989 CD cord-353298-vr5hnzp8 248 54 ; ; : cord-353298-vr5hnzp8 248 55 Godfraind Godfraind NNP cord-353298-vr5hnzp8 248 56 et et NNP cord-353298-vr5hnzp8 248 57 al al NNP cord-353298-vr5hnzp8 248 58 . . NNP cord-353298-vr5hnzp8 248 59 , , , cord-353298-vr5hnzp8 248 60 1989 1989 CD cord-353298-vr5hnzp8 248 61 ) ) -RRB- cord-353298-vr5hnzp8 248 62 . . . cord-353298-vr5hnzp8 249 1 We -PRON- PRP cord-353298-vr5hnzp8 249 2 found find VBD cord-353298-vr5hnzp8 249 3 that that IN cord-353298-vr5hnzp8 249 4 myelin myelin JJ cord-353298-vr5hnzp8 249 5 basic basic JJ cord-353298-vr5hnzp8 249 6 protein protein NN cord-353298-vr5hnzp8 249 7 mRNA mRNA NNP cord-353298-vr5hnzp8 249 8 isoforms isoform NNS cord-353298-vr5hnzp8 249 9 containing contain VBG cord-353298-vr5hnzp8 249 10 exon-2 exon-2 NNP cord-353298-vr5hnzp8 249 11 , , , cord-353298-vr5hnzp8 249 12 which which WDT cord-353298-vr5hnzp8 249 13 are be VBP cord-353298-vr5hnzp8 249 14 normally normally RB cord-353298-vr5hnzp8 249 15 abundant abundant JJ cord-353298-vr5hnzp8 249 16 only only RB cord-353298-vr5hnzp8 249 17 during during IN cord-353298-vr5hnzp8 249 18 development development NN cord-353298-vr5hnzp8 249 19 , , , cord-353298-vr5hnzp8 249 20 are be VBP cord-353298-vr5hnzp8 249 21 reexpressed reexpresse VBN cord-353298-vr5hnzp8 249 22 at at IN cord-353298-vr5hnzp8 249 23 dramatically dramatically RB cord-353298-vr5hnzp8 249 24 increased increase VBN cord-353298-vr5hnzp8 249 25 levels level NNS cord-353298-vr5hnzp8 249 26 during during IN cord-353298-vr5hnzp8 249 27 remyelination remyelination NN cord-353298-vr5hnzp8 249 28 ( ( -LRB- cord-353298-vr5hnzp8 249 29 Jordan Jordan NNP cord-353298-vr5hnzp8 249 30 et et NNP cord-353298-vr5hnzp8 249 31 al al NNP cord-353298-vr5hnzp8 249 32 . . NNP cord-353298-vr5hnzp8 249 33 , , , cord-353298-vr5hnzp8 249 34 1990 1990 CD cord-353298-vr5hnzp8 249 35 ) ) -RRB- cord-353298-vr5hnzp8 249 36 . . . cord-353298-vr5hnzp8 250 1 This this DT cord-353298-vr5hnzp8 250 2 recapitulation recapitulation NN cord-353298-vr5hnzp8 250 3 of of IN cord-353298-vr5hnzp8 250 4 molecular molecular JJ cord-353298-vr5hnzp8 250 5 events event NNS cord-353298-vr5hnzp8 250 6 characteristic characteristic JJ cord-353298-vr5hnzp8 250 7 of of IN cord-353298-vr5hnzp8 250 8 development development NN cord-353298-vr5hnzp8 250 9 suggests suggest VBZ cord-353298-vr5hnzp8 250 10 that that IN cord-353298-vr5hnzp8 250 11 newly newly RB cord-353298-vr5hnzp8 250 12 generated generate VBN cord-353298-vr5hnzp8 250 13 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 250 14 are be VBP cord-353298-vr5hnzp8 250 15 responsible responsible JJ cord-353298-vr5hnzp8 250 16 for for IN cord-353298-vr5hnzp8 250 17 remyelination remyelination NN cord-353298-vr5hnzp8 250 18 in in IN cord-353298-vr5hnzp8 250 19 this this DT cord-353298-vr5hnzp8 250 20 disease disease NN cord-353298-vr5hnzp8 250 21 . . . cord-353298-vr5hnzp8 251 1 Studies study NNS cord-353298-vr5hnzp8 251 2 using use VBG cord-353298-vr5hnzp8 251 3 triple triple JJ cord-353298-vr5hnzp8 251 4 - - HYPH cord-353298-vr5hnzp8 251 5 label label NN cord-353298-vr5hnzp8 251 6 immunocytochemistry immunocytochemistry NN cord-353298-vr5hnzp8 251 7 combined combine VBN cord-353298-vr5hnzp8 251 8 with with IN cord-353298-vr5hnzp8 251 9 autoradiography autoradiography NNP cord-353298-vr5hnzp8 251 10 have have VBP cord-353298-vr5hnzp8 251 11 identified identify VBN cord-353298-vr5hnzp8 251 12 O-2A O-2A NNP cord-353298-vr5hnzp8 251 13 progenitor progenitor NN cord-353298-vr5hnzp8 251 14 cells cell NNS cord-353298-vr5hnzp8 251 15 in in IN cord-353298-vr5hnzp8 251 16 1 1 CD cord-353298-vr5hnzp8 252 1 ~m ~m JJ cord-353298-vr5hnzp8 252 2 frozen frozen JJ cord-353298-vr5hnzp8 252 3 sections section NNS cord-353298-vr5hnzp8 252 4 of of IN cord-353298-vr5hnzp8 252 5 the the DT cord-353298-vr5hnzp8 252 6 spinal spinal JJ cord-353298-vr5hnzp8 252 7 cord cord NN cord-353298-vr5hnzp8 252 8 of of IN cord-353298-vr5hnzp8 252 9 these these DT cord-353298-vr5hnzp8 252 10 infected infect VBN cord-353298-vr5hnzp8 252 11 mice mouse NNS cord-353298-vr5hnzp8 253 1 ( ( -LRB- cord-353298-vr5hnzp8 253 2 Godfraind Godfraind NNP cord-353298-vr5hnzp8 253 3 et et NNP cord-353298-vr5hnzp8 253 4 al al NNP cord-353298-vr5hnzp8 253 5 . . NNP cord-353298-vr5hnzp8 253 6 , , , cord-353298-vr5hnzp8 253 7 1989 1989 CD cord-353298-vr5hnzp8 253 8 ) ) -RRB- cord-353298-vr5hnzp8 253 9 . . . cord-353298-vr5hnzp8 254 1 O-2A O-2A NNP cord-353298-vr5hnzp8 254 2 progenitors progenitor NNS cord-353298-vr5hnzp8 254 3 and and CC cord-353298-vr5hnzp8 254 4 O4-positive O4-positive NNS cord-353298-vr5hnzp8 254 5 astrocytes astrocyte NNS cord-353298-vr5hnzp8 254 6 proliferated proliferate VBN cord-353298-vr5hnzp8 254 7 early early RB cord-353298-vr5hnzp8 254 8 in in IN cord-353298-vr5hnzp8 254 9 the the DT cord-353298-vr5hnzp8 254 10 course course NN cord-353298-vr5hnzp8 254 11 of of IN cord-353298-vr5hnzp8 254 12 the the DT cord-353298-vr5hnzp8 254 13 disease disease NN cord-353298-vr5hnzp8 254 14 and and CC cord-353298-vr5hnzp8 254 15 some some DT cord-353298-vr5hnzp8 254 16 Figure figure NN cord-353298-vr5hnzp8 254 17 12 12 CD cord-353298-vr5hnzp8 254 18 . . . cord-353298-vr5hnzp8 255 1 An an DT cord-353298-vr5hnzp8 255 2 O-2A O-2A NNP cord-353298-vr5hnzp8 255 3 adult adult NN cord-353298-vr5hnzp8 255 4 progenitor progenitor NN cord-353298-vr5hnzp8 255 5 cultured culture VBN cord-353298-vr5hnzp8 255 6 from from IN cord-353298-vr5hnzp8 255 7 demyelinated demyelinated JJ cord-353298-vr5hnzp8 255 8 tissue tissue NN cord-353298-vr5hnzp8 255 9 ( ( -LRB- cord-353298-vr5hnzp8 255 10 4 4 CD cord-353298-vr5hnzp8 255 11 wpi wpi NN cord-353298-vr5hnzp8 255 12 ) ) -RRB- cord-353298-vr5hnzp8 255 13 and and CC cord-353298-vr5hnzp8 255 14 processed process VBN cord-353298-vr5hnzp8 255 15 as as IN cord-353298-vr5hnzp8 255 16 described describe VBN cord-353298-vr5hnzp8 255 17 in in IN cord-353298-vr5hnzp8 255 18 Fig Fig NNP cord-353298-vr5hnzp8 255 19 . . . cord-353298-vr5hnzp8 256 1 10 10 CD cord-353298-vr5hnzp8 256 2 is be VBZ cord-353298-vr5hnzp8 256 3 recognized recognize VBN cord-353298-vr5hnzp8 256 4 by by IN cord-353298-vr5hnzp8 256 5 its -PRON- PRP$ cord-353298-vr5hnzp8 256 6 reactivity reactivity NN cord-353298-vr5hnzp8 256 7 with with IN cord-353298-vr5hnzp8 256 8 the the DT cord-353298-vr5hnzp8 256 9 04 04 CD cord-353298-vr5hnzp8 256 10 antibody antibody NN cord-353298-vr5hnzp8 256 11 ( ( -LRB- cord-353298-vr5hnzp8 256 12 A a NN cord-353298-vr5hnzp8 256 13 ; ; , cord-353298-vr5hnzp8 256 14 rhodamine rhodamine JJ cord-353298-vr5hnzp8 256 15 optics optic NNS cord-353298-vr5hnzp8 256 16 ) ) -RRB- cord-353298-vr5hnzp8 256 17 and and CC cord-353298-vr5hnzp8 256 18 in in IN cord-353298-vr5hnzp8 256 19 the the DT cord-353298-vr5hnzp8 256 20 absence absence NN cord-353298-vr5hnzp8 256 21 of of IN cord-353298-vr5hnzp8 256 22 staining stain VBG cord-353298-vr5hnzp8 256 23 with with IN cord-353298-vr5hnzp8 256 24 GC GC NNP cord-353298-vr5hnzp8 256 25 ( ( -LRB- cord-353298-vr5hnzp8 256 26 B b NN cord-353298-vr5hnzp8 256 27 ; ; : cord-353298-vr5hnzp8 256 28 fluorescein fluorescein NNP cord-353298-vr5hnzp8 256 29 optics optics NNPS cord-353298-vr5hnzp8 256 30 ) ) -RRB- cord-353298-vr5hnzp8 256 31 or or CC cord-353298-vr5hnzp8 256 32 GFAP GFAP NNP cord-353298-vr5hnzp8 256 33 ( ( -LRB- cord-353298-vr5hnzp8 256 34 C c NN cord-353298-vr5hnzp8 256 35 ; ; , cord-353298-vr5hnzp8 256 36 coumarin coumarin NN cord-353298-vr5hnzp8 256 37 optics optic NNS cord-353298-vr5hnzp8 256 38 ) ) -RRB- cord-353298-vr5hnzp8 256 39 antibodies antibody NNS cord-353298-vr5hnzp8 256 40 . . . cord-353298-vr5hnzp8 257 1 The the DT cord-353298-vr5hnzp8 257 2 cluster cluster NN cord-353298-vr5hnzp8 257 3 of of IN cord-353298-vr5hnzp8 257 4 silver silver JJ cord-353298-vr5hnzp8 257 5 grains grain NNS cord-353298-vr5hnzp8 257 6 over over IN cord-353298-vr5hnzp8 257 7 the the DT cord-353298-vr5hnzp8 257 8 nucleus nucleus NN cord-353298-vr5hnzp8 257 9 ( ( -LRB- cord-353298-vr5hnzp8 257 10 D D NNP cord-353298-vr5hnzp8 257 11 , , , cord-353298-vr5hnzp8 257 12 arrow arrow NN cord-353298-vr5hnzp8 257 13 ) ) -RRB- cord-353298-vr5hnzp8 257 14 indicates indicate VBZ cord-353298-vr5hnzp8 257 15 that that IN cord-353298-vr5hnzp8 257 16 this this DT cord-353298-vr5hnzp8 257 17 cell cell NN cord-353298-vr5hnzp8 257 18 incorporated incorporate VBD cord-353298-vr5hnzp8 257 19 [ [ -LRB- cord-353298-vr5hnzp8 257 20 3H]thymidine 3h]thymidine CD cord-353298-vr5hnzp8 257 21 during during IN cord-353298-vr5hnzp8 257 22 the the DT cord-353298-vr5hnzp8 257 23 20-h 20-h CD cord-353298-vr5hnzp8 257 24 in in FW cord-353298-vr5hnzp8 257 25 vitro vitro FW cord-353298-vr5hnzp8 257 26 pulse pulse NN cord-353298-vr5hnzp8 257 27 . . . cord-353298-vr5hnzp8 258 1 ( ( -LRB- cord-353298-vr5hnzp8 258 2 E e NN cord-353298-vr5hnzp8 258 3 ) ) -RRB- cord-353298-vr5hnzp8 258 4 Phase phase NN cord-353298-vr5hnzp8 258 5 contrast contrast NN cord-353298-vr5hnzp8 258 6 showing show VBG cord-353298-vr5hnzp8 258 7 the the DT cord-353298-vr5hnzp8 258 8 cell cell NN cord-353298-vr5hnzp8 258 9 processes process NNS cord-353298-vr5hnzp8 258 10 . . . cord-353298-vr5hnzp8 259 1 Note note VB cord-353298-vr5hnzp8 259 2 that that IN cord-353298-vr5hnzp8 259 3 numerous numerous JJ cord-353298-vr5hnzp8 259 4 microglial microglial JJ cord-353298-vr5hnzp8 259 5 cells cell NNS cord-353298-vr5hnzp8 259 6 are be VBP cord-353298-vr5hnzp8 259 7 also also RB cord-353298-vr5hnzp8 259 8 present present JJ cord-353298-vr5hnzp8 259 9 in in IN cord-353298-vr5hnzp8 259 10 this this DT cord-353298-vr5hnzp8 259 11 culture culture NN cord-353298-vr5hnzp8 259 12 . . . cord-353298-vr5hnzp8 260 1 Bar bar NN cord-353298-vr5hnzp8 260 2 , , , cord-353298-vr5hnzp8 260 3 50 50 CD cord-353298-vr5hnzp8 260 4 # # NN cord-353298-vr5hnzp8 260 5 m. m. NN cord-353298-vr5hnzp8 260 6 cells cell NNS cord-353298-vr5hnzp8 260 7 generated generate VBN cord-353298-vr5hnzp8 260 8 during during IN cord-353298-vr5hnzp8 260 9 the the DT cord-353298-vr5hnzp8 260 10 demyelination demyelination NN cord-353298-vr5hnzp8 260 11 stage stage NN cord-353298-vr5hnzp8 260 12 later later RB cord-353298-vr5hnzp8 260 13 developed develop VBN cord-353298-vr5hnzp8 260 14 into into IN cord-353298-vr5hnzp8 260 15 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 260 16 ( ( -LRB- cord-353298-vr5hnzp8 260 17 Godfraind Godfraind NNP cord-353298-vr5hnzp8 260 18 et et NNP cord-353298-vr5hnzp8 260 19 al al NNP cord-353298-vr5hnzp8 260 20 . . NNP cord-353298-vr5hnzp8 260 21 , , , cord-353298-vr5hnzp8 260 22 1989 1989 CD cord-353298-vr5hnzp8 260 23 ) ) -RRB- cord-353298-vr5hnzp8 260 24 . . . cord-353298-vr5hnzp8 261 1 In in IN cord-353298-vr5hnzp8 261 2 the the DT cord-353298-vr5hnzp8 261 3 present present JJ cord-353298-vr5hnzp8 261 4 study study NN cord-353298-vr5hnzp8 261 5 , , , cord-353298-vr5hnzp8 261 6 we -PRON- PRP cord-353298-vr5hnzp8 261 7 demonstrate demonstrate VBP cord-353298-vr5hnzp8 261 8 that that IN cord-353298-vr5hnzp8 261 9 the the DT cord-353298-vr5hnzp8 261 10 mitotic mitotic JJ cord-353298-vr5hnzp8 261 11 activity activity NN cord-353298-vr5hnzp8 261 12 of of IN cord-353298-vr5hnzp8 261 13 O-2A O-2A NNP cord-353298-vr5hnzp8 261 14 lineage lineage NN cord-353298-vr5hnzp8 261 15 cells cell NNS cord-353298-vr5hnzp8 261 16 observed observe VBN cord-353298-vr5hnzp8 261 17 in in IN cord-353298-vr5hnzp8 261 18 vivo vivo NN cord-353298-vr5hnzp8 261 19 during during IN cord-353298-vr5hnzp8 261 20 demyelination demyelination NN cord-353298-vr5hnzp8 261 21 has have VBZ cord-353298-vr5hnzp8 261 22 been be VBN cord-353298-vr5hnzp8 261 23 maintained maintain VBN cord-353298-vr5hnzp8 261 24 in in IN cord-353298-vr5hnzp8 261 25 vitro vitro FW cord-353298-vr5hnzp8 261 26 . . . cord-353298-vr5hnzp8 262 1 This this DT cord-353298-vr5hnzp8 262 2 proliferation proliferation NN cord-353298-vr5hnzp8 262 3 might may MD cord-353298-vr5hnzp8 262 4 be be VB cord-353298-vr5hnzp8 262 5 mediated mediate VBN cord-353298-vr5hnzp8 262 6 by by IN cord-353298-vr5hnzp8 262 7 factors factor NNS cord-353298-vr5hnzp8 262 8 active active JJ cord-353298-vr5hnzp8 262 9 in in IN cord-353298-vr5hnzp8 262 10 the the DT cord-353298-vr5hnzp8 262 11 culture culture NN cord-353298-vr5hnzp8 262 12 milieu milieu NN cord-353298-vr5hnzp8 262 13 or or CC cord-353298-vr5hnzp8 262 14 by by IN cord-353298-vr5hnzp8 262 15 signals signal NNS cord-353298-vr5hnzp8 262 16 experienced experience VBN cord-353298-vr5hnzp8 262 17 in in IN cord-353298-vr5hnzp8 262 18 vivo vivo NN cord-353298-vr5hnzp8 262 19 which which WDT cord-353298-vr5hnzp8 262 20 persist persist VBP cord-353298-vr5hnzp8 262 21 in in IN cord-353298-vr5hnzp8 262 22 vitro vitro FW cord-353298-vr5hnzp8 262 23 . . . cord-353298-vr5hnzp8 263 1 The the DT cord-353298-vr5hnzp8 263 2 nature nature NN cord-353298-vr5hnzp8 263 3 of of IN cord-353298-vr5hnzp8 263 4 the the DT cord-353298-vr5hnzp8 263 5 signal(s signal(s NN cord-353298-vr5hnzp8 263 6 ) ) -RRB- cord-353298-vr5hnzp8 263 7 triggering trigger VBG cord-353298-vr5hnzp8 263 8 this this DT cord-353298-vr5hnzp8 263 9 proliferation proliferation NN cord-353298-vr5hnzp8 263 10 is be VBZ cord-353298-vr5hnzp8 263 11 presently presently RB cord-353298-vr5hnzp8 263 12 unknown unknown JJ cord-353298-vr5hnzp8 263 13 . . . cord-353298-vr5hnzp8 264 1 Reactive reactive JJ cord-353298-vr5hnzp8 264 2 astrocytes astrocyte NNS cord-353298-vr5hnzp8 264 3 may may MD cord-353298-vr5hnzp8 264 4 secrete secrete VB cord-353298-vr5hnzp8 264 5 mitogenic mitogenic JJ cord-353298-vr5hnzp8 264 6 factors factor NNS cord-353298-vr5hnzp8 264 7 while while IN cord-353298-vr5hnzp8 264 8 microglia microglia NNS cord-353298-vr5hnzp8 264 9 can can MD cord-353298-vr5hnzp8 264 10 synthesize synthesize VB cord-353298-vr5hnzp8 264 11 lymphokines lymphokine NNS cord-353298-vr5hnzp8 264 12 in in IN cord-353298-vr5hnzp8 264 13 response response NN cord-353298-vr5hnzp8 264 14 to to IN cord-353298-vr5hnzp8 264 15 trauma trauma NN cord-353298-vr5hnzp8 264 16 ( ( -LRB- cord-353298-vr5hnzp8 264 17 Giulian Giulian NNP cord-353298-vr5hnzp8 264 18 , , , cord-353298-vr5hnzp8 264 19 1987 1987 CD cord-353298-vr5hnzp8 264 20 ; ; : cord-353298-vr5hnzp8 264 21 Giulian Giulian NNP cord-353298-vr5hnzp8 264 22 et et NNP cord-353298-vr5hnzp8 264 23 al al NNP cord-353298-vr5hnzp8 264 24 . . NNP cord-353298-vr5hnzp8 264 25 , , , cord-353298-vr5hnzp8 264 26 1988 1988 CD cord-353298-vr5hnzp8 264 27 ) ) -RRB- cord-353298-vr5hnzp8 264 28 . . . cord-353298-vr5hnzp8 265 1 Since since IN cord-353298-vr5hnzp8 265 2 microglial microglial JJ cord-353298-vr5hnzp8 265 3 cells cell NNS cord-353298-vr5hnzp8 265 4 are be VBP cord-353298-vr5hnzp8 265 5 present present JJ cord-353298-vr5hnzp8 265 6 in in IN cord-353298-vr5hnzp8 265 7 our -PRON- PRP$ cord-353298-vr5hnzp8 265 8 cultures culture NNS cord-353298-vr5hnzp8 265 9 of of IN cord-353298-vr5hnzp8 265 10 adult adult NN cord-353298-vr5hnzp8 265 11 spinal spinal JJ cord-353298-vr5hnzp8 265 12 cord cord NN cord-353298-vr5hnzp8 265 13 and and CC cord-353298-vr5hnzp8 265 14 are be VBP cord-353298-vr5hnzp8 265 15 much much RB cord-353298-vr5hnzp8 265 16 more more RBR cord-353298-vr5hnzp8 265 17 prevalent prevalent JJ cord-353298-vr5hnzp8 265 18 in in IN cord-353298-vr5hnzp8 265 19 cultures culture NNS cord-353298-vr5hnzp8 265 20 of of IN cord-353298-vr5hnzp8 265 21 demyelinated demyelinated JJ cord-353298-vr5hnzp8 265 22 tissue tissue NN cord-353298-vr5hnzp8 265 23 , , , cord-353298-vr5hnzp8 265 24 it -PRON- PRP cord-353298-vr5hnzp8 265 25 is be VBZ cord-353298-vr5hnzp8 265 26 possible possible JJ cord-353298-vr5hnzp8 265 27 that that IN cord-353298-vr5hnzp8 265 28 O-2A O-2A NNP cord-353298-vr5hnzp8 265 29 lineage lineage NN cord-353298-vr5hnzp8 265 30 cells cell NNS cord-353298-vr5hnzp8 265 31 proliferate proliferate VBP cord-353298-vr5hnzp8 265 32 due due IN cord-353298-vr5hnzp8 265 33 to to IN cord-353298-vr5hnzp8 265 34 factors factor NNS cord-353298-vr5hnzp8 265 35 released release VBN cord-353298-vr5hnzp8 265 36 into into IN cord-353298-vr5hnzp8 265 37 the the DT cord-353298-vr5hnzp8 265 38 culture culture NN cord-353298-vr5hnzp8 265 39 milieu milieu NN cord-353298-vr5hnzp8 265 40 by by IN cord-353298-vr5hnzp8 265 41 these these DT cord-353298-vr5hnzp8 265 42 cells cell NNS cord-353298-vr5hnzp8 265 43 . . . cord-353298-vr5hnzp8 266 1 In in IN cord-353298-vr5hnzp8 266 2 addition addition NN cord-353298-vr5hnzp8 266 3 to to IN cord-353298-vr5hnzp8 266 4 soluble soluble JJ cord-353298-vr5hnzp8 266 5 factors factor NNS cord-353298-vr5hnzp8 266 6 , , , cord-353298-vr5hnzp8 266 7 denuded denuded JJ cord-353298-vr5hnzp8 266 8 axons axon NNS cord-353298-vr5hnzp8 266 9 or or CC cord-353298-vr5hnzp8 266 10 axolemmal axolemmal VBN cord-353298-vr5hnzp8 266 11 components component NNS cord-353298-vr5hnzp8 266 12 , , , cord-353298-vr5hnzp8 266 13 which which WDT cord-353298-vr5hnzp8 266 14 are be VBP cord-353298-vr5hnzp8 266 15 mitogenic mitogenic NNP cord-353298-vr5hnzp8 266 16 for for IN cord-353298-vr5hnzp8 266 17 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 266 18 from from IN cord-353298-vr5hnzp8 266 19 developing develop VBG cord-353298-vr5hnzp8 266 20 CNS CNS NNP cord-353298-vr5hnzp8 266 21 ( ( -LRB- cord-353298-vr5hnzp8 266 22 Chen Chen NNP cord-353298-vr5hnzp8 266 23 and and CC cord-353298-vr5hnzp8 266 24 DeVries DeVries NNP cord-353298-vr5hnzp8 266 25 , , , cord-353298-vr5hnzp8 266 26 1989 1989 CD cord-353298-vr5hnzp8 266 27 ) ) -RRB- cord-353298-vr5hnzp8 266 28 , , , cord-353298-vr5hnzp8 266 29 may may MD cord-353298-vr5hnzp8 266 30 act act VB cord-353298-vr5hnzp8 266 31 as as IN cord-353298-vr5hnzp8 266 32 mitogens mitogens NNP cord-353298-vr5hnzp8 266 33 for for IN cord-353298-vr5hnzp8 266 34 O-2A O-2A NNP cord-353298-vr5hnzp8 266 35 lineage lineage NN cord-353298-vr5hnzp8 266 36 cells cell NNS cord-353298-vr5hnzp8 266 37 during during IN cord-353298-vr5hnzp8 266 38 demyelination demyelination NN cord-353298-vr5hnzp8 266 39 . . . cord-353298-vr5hnzp8 267 1 Denuded denuded JJ cord-353298-vr5hnzp8 267 2 axons axon NNS cord-353298-vr5hnzp8 267 3 in in IN cord-353298-vr5hnzp8 267 4 demyelinated demyelinated JJ cord-353298-vr5hnzp8 267 5 lesions lesion NNS cord-353298-vr5hnzp8 267 6 may may MD cord-353298-vr5hnzp8 267 7 stimulate stimulate VB cord-353298-vr5hnzp8 267 8 proliferation proliferation NN cord-353298-vr5hnzp8 267 9 directly directly RB cord-353298-vr5hnzp8 267 10 , , , cord-353298-vr5hnzp8 267 11 or or CC cord-353298-vr5hnzp8 267 12 may may MD cord-353298-vr5hnzp8 267 13 " " `` cord-353298-vr5hnzp8 267 14 prime prime JJ cord-353298-vr5hnzp8 267 15 " " '' cord-353298-vr5hnzp8 267 16 O-2A O-2A NNP cord-353298-vr5hnzp8 267 17 lineage lineage NN cord-353298-vr5hnzp8 267 18 cells cell NNS cord-353298-vr5hnzp8 267 19 to to TO cord-353298-vr5hnzp8 267 20 divide divide VB cord-353298-vr5hnzp8 267 21 in in IN cord-353298-vr5hnzp8 267 22 response response NN cord-353298-vr5hnzp8 267 23 to to IN cord-353298-vr5hnzp8 267 24 specific specific JJ cord-353298-vr5hnzp8 267 25 growth growth NN cord-353298-vr5hnzp8 267 26 factors factor NNS cord-353298-vr5hnzp8 267 27 . . . cord-353298-vr5hnzp8 268 1 Previous previous JJ cord-353298-vr5hnzp8 268 2 studies study NNS cord-353298-vr5hnzp8 268 3 have have VBP cord-353298-vr5hnzp8 268 4 shown show VBN cord-353298-vr5hnzp8 268 5 that that IN cord-353298-vr5hnzp8 268 6 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 268 7 isolated isolate VBN cord-353298-vr5hnzp8 268 8 from from IN cord-353298-vr5hnzp8 268 9 adult adult JJ cord-353298-vr5hnzp8 268 10 spinal spinal JJ cord-353298-vr5hnzp8 268 11 cord cord NN cord-353298-vr5hnzp8 268 12 and and CC cord-353298-vr5hnzp8 268 13 expressing express VBG cord-353298-vr5hnzp8 268 14 GC GC NNP cord-353298-vr5hnzp8 268 15 , , , cord-353298-vr5hnzp8 268 16 but but CC cord-353298-vr5hnzp8 268 17 not not RB cord-353298-vr5hnzp8 268 18 myelin myelin JJ cord-353298-vr5hnzp8 268 19 basic basic JJ cord-353298-vr5hnzp8 268 20 protein protein NN cord-353298-vr5hnzp8 268 21 , , , cord-353298-vr5hnzp8 268 22 can can MD cord-353298-vr5hnzp8 268 23 divide divide VB cord-353298-vr5hnzp8 268 24 in in IN cord-353298-vr5hnzp8 268 25 the the DT cord-353298-vr5hnzp8 268 26 presence presence NN cord-353298-vr5hnzp8 268 27 of of IN cord-353298-vr5hnzp8 268 28 neurons neuron NNS cord-353298-vr5hnzp8 268 29 ( ( -LRB- cord-353298-vr5hnzp8 268 30 Wood Wood NNP cord-353298-vr5hnzp8 268 31 and and CC cord-353298-vr5hnzp8 268 32 Bunge Bunge NNP cord-353298-vr5hnzp8 268 33 , , , cord-353298-vr5hnzp8 268 34 1986 1986 CD cord-353298-vr5hnzp8 268 35 ) ) -RRB- cord-353298-vr5hnzp8 268 36 . . . cord-353298-vr5hnzp8 269 1 Along along IN cord-353298-vr5hnzp8 269 2 with with IN cord-353298-vr5hnzp8 269 3 O-2A O-2A NNP cord-353298-vr5hnzp8 269 4 progenitors progenitor NNS cord-353298-vr5hnzp8 269 5 , , , cord-353298-vr5hnzp8 269 6 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 269 7 expressing express VBG cord-353298-vr5hnzp8 269 8 GC GC NNP cord-353298-vr5hnzp8 269 9 also also RB cord-353298-vr5hnzp8 269 10 proliferated proliferate VBD cord-353298-vr5hnzp8 269 11 in in IN cord-353298-vr5hnzp8 269 12 our -PRON- PRP$ cord-353298-vr5hnzp8 269 13 cultures culture NNS cord-353298-vr5hnzp8 269 14 from from IN cord-353298-vr5hnzp8 269 15 remyelinating remyelinate VBG cord-353298-vr5hnzp8 269 16 animals animal NNS cord-353298-vr5hnzp8 269 17 . . . cord-353298-vr5hnzp8 270 1 Thus thus RB cord-353298-vr5hnzp8 270 2 , , , cord-353298-vr5hnzp8 270 3 proliferating proliferate VBG cord-353298-vr5hnzp8 270 4 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 270 5 could could MD cord-353298-vr5hnzp8 270 6 also also RB cord-353298-vr5hnzp8 270 7 be be VB cord-353298-vr5hnzp8 270 8 a a DT cord-353298-vr5hnzp8 270 9 major major JJ cord-353298-vr5hnzp8 270 10 source source NN cord-353298-vr5hnzp8 270 11 of of IN cord-353298-vr5hnzp8 270 12 remyelinating remyelinate VBG cord-353298-vr5hnzp8 270 13 cells cell NNS cord-353298-vr5hnzp8 270 14 . . . cord-353298-vr5hnzp8 271 1 Type type NN cord-353298-vr5hnzp8 271 2 2 2 CD cord-353298-vr5hnzp8 271 3 astrocytes astrocyte NNS cord-353298-vr5hnzp8 271 4 and and CC cord-353298-vr5hnzp8 271 5 cells cell NNS cord-353298-vr5hnzp8 271 6 with with IN cord-353298-vr5hnzp8 271 7 a a DT cord-353298-vr5hnzp8 271 8 mixed mixed JJ cord-353298-vr5hnzp8 271 9 oligodendrocyte oligodendrocyte NN cord-353298-vr5hnzp8 271 10 - - HYPH cord-353298-vr5hnzp8 271 11 astrocyte astrocyte JJ cord-353298-vr5hnzp8 271 12 phenotype phenotype NN cord-353298-vr5hnzp8 271 13 also also RB cord-353298-vr5hnzp8 271 14 proliferated proliferate VBD cord-353298-vr5hnzp8 271 15 in in IN cord-353298-vr5hnzp8 271 16 response response NN cord-353298-vr5hnzp8 271 17 to to IN cord-353298-vr5hnzp8 271 18 demyelination demyelination NN cord-353298-vr5hnzp8 271 19 . . . cord-353298-vr5hnzp8 272 1 Cells cell NNS cord-353298-vr5hnzp8 272 2 with with IN cord-353298-vr5hnzp8 272 3 characteristics characteristic NNS cord-353298-vr5hnzp8 272 4 of of IN cord-353298-vr5hnzp8 272 5 both both DT cord-353298-vr5hnzp8 272 6 o o NN cord-353298-vr5hnzp8 272 7 l l NNP cord-353298-vr5hnzp8 272 8 i~ i~ NNP cord-353298-vr5hnzp8 272 9 and and CC cord-353298-vr5hnzp8 272 10 astrocyte astrocyte NNP cord-353298-vr5hnzp8 272 11 phenotypes phenotype NNS cord-353298-vr5hnzp8 272 12 have have VBP cord-353298-vr5hnzp8 272 13 been be VBN cord-353298-vr5hnzp8 272 14 described describe VBN cord-353298-vr5hnzp8 272 15 in in IN cord-353298-vr5hnzp8 272 16 several several JJ cord-353298-vr5hnzp8 272 17 in in IN cord-353298-vr5hnzp8 272 18 vivo vivo NNP cord-353298-vr5hnzp8 272 19 studies study NNS cord-353298-vr5hnzp8 272 20 of of IN cord-353298-vr5hnzp8 272 21 demyelinating demyelinate VBG cord-353298-vr5hnzp8 272 22 tissue tissue NN cord-353298-vr5hnzp8 273 1 ( ( -LRB- cord-353298-vr5hnzp8 273 2 Bunge Bunge NNP cord-353298-vr5hnzp8 273 3 et et NNP cord-353298-vr5hnzp8 273 4 al al NNP cord-353298-vr5hnzp8 273 5 . . NNP cord-353298-vr5hnzp8 273 6 , , , cord-353298-vr5hnzp8 273 7 1961 1961 CD cord-353298-vr5hnzp8 273 8 ; ; : cord-353298-vr5hnzp8 273 9 Carrollet Carrollet NNP cord-353298-vr5hnzp8 273 10 al al NNP cord-353298-vr5hnzp8 273 11 . . NNP cord-353298-vr5hnzp8 273 12 , , , cord-353298-vr5hnzp8 273 13 1987 1987 CD cord-353298-vr5hnzp8 273 14 ; ; : cord-353298-vr5hnzp8 273 15 Godfralnd Godfralnd NNP cord-353298-vr5hnzp8 273 16 et et NNP cord-353298-vr5hnzp8 273 17 al al NNP cord-353298-vr5hnzp8 273 18 . . . cord-353298-vr5hnzp8 274 1 , , , cord-353298-vr5hnzp8 274 2 1989 1989 CD cord-353298-vr5hnzp8 274 3 ; ; : cord-353298-vr5hnzp8 274 4 Paine Paine NNP cord-353298-vr5hnzp8 274 5 , , , cord-353298-vr5hnzp8 274 6 1989 1989 CD cord-353298-vr5hnzp8 274 7 ) ) -RRB- cord-353298-vr5hnzp8 274 8 . . . cord-353298-vr5hnzp8 275 1 Additionally additionally RB cord-353298-vr5hnzp8 275 2 , , , cord-353298-vr5hnzp8 275 3 ciliary ciliary NN cord-353298-vr5hnzp8 275 4 neurotrophic neurotrophic NN cord-353298-vr5hnzp8 275 5 factor factor NN cord-353298-vr5hnzp8 275 6 , , , cord-353298-vr5hnzp8 275 7 which which WDT cord-353298-vr5hnzp8 275 8 induces induce VBZ cord-353298-vr5hnzp8 275 9 transient transient JJ cord-353298-vr5hnzp8 275 10 GFAP GFAP NNP cord-353298-vr5hnzp8 275 11 expression expression NN cord-353298-vr5hnzp8 275 12 in in IN cord-353298-vr5hnzp8 275 13 neonatal neonatal JJ cord-353298-vr5hnzp8 275 14 O-2A O-2A NNP cord-353298-vr5hnzp8 275 15 progenitors progenitor NNS cord-353298-vr5hnzp8 275 16 in in IN cord-353298-vr5hnzp8 275 17 vitro vitro FW cord-353298-vr5hnzp8 275 18 , , , cord-353298-vr5hnzp8 275 19 is be VBZ cord-353298-vr5hnzp8 275 20 much much RB cord-353298-vr5hnzp8 275 21 more more RBR cord-353298-vr5hnzp8 275 22 abundant abundant JJ cord-353298-vr5hnzp8 275 23 in in IN cord-353298-vr5hnzp8 275 24 regenerating regenerate VBG cord-353298-vr5hnzp8 275 25 CNS cns NN cord-353298-vr5hnzp8 275 26 tissue tissue NN cord-353298-vr5hnzp8 276 1 ( ( -LRB- cord-353298-vr5hnzp8 276 2 Nieto Nieto NNP cord-353298-vr5hnzp8 276 3 - - HYPH cord-353298-vr5hnzp8 276 4 Sampedro Sampedro NNP cord-353298-vr5hnzp8 276 5 et et NNP cord-353298-vr5hnzp8 276 6 al al NNP cord-353298-vr5hnzp8 276 7 . . NNP cord-353298-vr5hnzp8 276 8 , , , cord-353298-vr5hnzp8 276 9 1983 1983 CD cord-353298-vr5hnzp8 276 10 ) ) -RRB- cord-353298-vr5hnzp8 276 11 and and CC cord-353298-vr5hnzp8 276 12 might may MD cord-353298-vr5hnzp8 276 13 possibly possibly RB cord-353298-vr5hnzp8 276 14 induce induce VB cord-353298-vr5hnzp8 276 15 a a DT cord-353298-vr5hnzp8 276 16 mixed mixed JJ cord-353298-vr5hnzp8 276 17 phenotype phenotype NN cord-353298-vr5hnzp8 276 18 in in IN cord-353298-vr5hnzp8 276 19 vivo vivo NN cord-353298-vr5hnzp8 276 20 . . . cord-353298-vr5hnzp8 277 1 The the DT cord-353298-vr5hnzp8 277 2 presence presence NN cord-353298-vr5hnzp8 277 3 of of IN cord-353298-vr5hnzp8 277 4 phenotypic phenotypic JJ cord-353298-vr5hnzp8 277 5 characteristics characteristic NNS cord-353298-vr5hnzp8 277 6 of of IN cord-353298-vr5hnzp8 277 7 both both DT cord-353298-vr5hnzp8 277 8 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 277 9 and and CC cord-353298-vr5hnzp8 277 10 astrocytes astrocyte NNS cord-353298-vr5hnzp8 277 11 in in IN cord-353298-vr5hnzp8 277 12 the the DT cord-353298-vr5hnzp8 277 13 same same JJ cord-353298-vr5hnzp8 277 14 cell cell NN cord-353298-vr5hnzp8 277 15 indicates indicate VBZ cord-353298-vr5hnzp8 277 16 that that IN cord-353298-vr5hnzp8 277 17 some some DT cord-353298-vr5hnzp8 277 18 degree degree NN cord-353298-vr5hnzp8 277 19 of of IN cord-353298-vr5hnzp8 277 20 plasticity plasticity NN cord-353298-vr5hnzp8 277 21 is be VBZ cord-353298-vr5hnzp8 277 22 possible possible JJ cord-353298-vr5hnzp8 277 23 between between IN cord-353298-vr5hnzp8 277 24 these these DT cord-353298-vr5hnzp8 277 25 two two CD cord-353298-vr5hnzp8 277 26 differentiation differentiation NN cord-353298-vr5hnzp8 277 27 pathways pathway NNS cord-353298-vr5hnzp8 277 28 . . . cord-353298-vr5hnzp8 278 1 Mixed mixed JJ cord-353298-vr5hnzp8 278 2 phenotype phenotype NN cord-353298-vr5hnzp8 278 3 cells cell NNS cord-353298-vr5hnzp8 278 4 might may MD cord-353298-vr5hnzp8 278 5 be be VB cord-353298-vr5hnzp8 278 6 precursor precursor NN cord-353298-vr5hnzp8 278 7 cells cell NNS cord-353298-vr5hnzp8 278 8 at at IN cord-353298-vr5hnzp8 278 9 an an DT cord-353298-vr5hnzp8 278 10 intermediate intermediate JJ cord-353298-vr5hnzp8 278 11 bipotential bipotential JJ cord-353298-vr5hnzp8 278 12 stage stage NN cord-353298-vr5hnzp8 278 13 which which WDT cord-353298-vr5hnzp8 278 14 are be VBP cord-353298-vr5hnzp8 278 15 responding respond VBG cord-353298-vr5hnzp8 278 16 to to IN cord-353298-vr5hnzp8 278 17 two two CD cord-353298-vr5hnzp8 278 18 differentiation differentiation NN cord-353298-vr5hnzp8 278 19 signals signal NNS cord-353298-vr5hnzp8 278 20 simultaneously simultaneously RB cord-353298-vr5hnzp8 278 21 , , , cord-353298-vr5hnzp8 278 22 or or CC cord-353298-vr5hnzp8 278 23 may may MD cord-353298-vr5hnzp8 278 24 be be VB cord-353298-vr5hnzp8 278 25 mature mature JJ cord-353298-vr5hnzp8 278 26 cells cell NNS cord-353298-vr5hnzp8 278 27 in in IN cord-353298-vr5hnzp8 278 28 a a DT cord-353298-vr5hnzp8 278 29 state state NN cord-353298-vr5hnzp8 278 30 of of IN cord-353298-vr5hnzp8 278 31 transdifferentiation transdifferentiation NN cord-353298-vr5hnzp8 278 32 between between IN cord-353298-vr5hnzp8 278 33 astrocyte astrocyte NNP cord-353298-vr5hnzp8 278 34 and and CC cord-353298-vr5hnzp8 278 35 oligodendrocyte oligodendrocyte NNP cord-353298-vr5hnzp8 278 36 phenotypes phenotype NNS cord-353298-vr5hnzp8 278 37 . . . cord-353298-vr5hnzp8 279 1 By by IN cord-353298-vr5hnzp8 279 2 either either DT cord-353298-vr5hnzp8 279 3 mechanism mechanism NN cord-353298-vr5hnzp8 279 4 , , , cord-353298-vr5hnzp8 279 5 mixed mixed JJ cord-353298-vr5hnzp8 279 6 phenotype phenotype NN cord-353298-vr5hnzp8 279 7 cells cell NNS cord-353298-vr5hnzp8 279 8 might may MD cord-353298-vr5hnzp8 279 9 provide provide VB cord-353298-vr5hnzp8 279 10 additional additional JJ cord-353298-vr5hnzp8 279 11 ways way NNS cord-353298-vr5hnzp8 279 12 to to TO cord-353298-vr5hnzp8 279 13 increase increase VB cord-353298-vr5hnzp8 279 14 the the DT cord-353298-vr5hnzp8 279 15 number number NN cord-353298-vr5hnzp8 279 16 of of IN cord-353298-vr5hnzp8 279 17 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 279 18 available available JJ cord-353298-vr5hnzp8 279 19 for for IN cord-353298-vr5hnzp8 279 20 remyelination remyelination NN cord-353298-vr5hnzp8 279 21 . . . cord-353298-vr5hnzp8 280 1 Now now RB cord-353298-vr5hnzp8 280 2 that that IN cord-353298-vr5hnzp8 280 3 we -PRON- PRP cord-353298-vr5hnzp8 280 4 have have VBP cord-353298-vr5hnzp8 280 5 established establish VBN cord-353298-vr5hnzp8 280 6 and and CC cord-353298-vr5hnzp8 280 7 characterized characterize VBN cord-353298-vr5hnzp8 280 8 an an DT cord-353298-vr5hnzp8 280 9 in in IN cord-353298-vr5hnzp8 280 10 vitro vitro FW cord-353298-vr5hnzp8 280 11 system system NN cord-353298-vr5hnzp8 280 12 of of IN cord-353298-vr5hnzp8 280 13 glial glial JJ cord-353298-vr5hnzp8 280 14 cells cell NNS cord-353298-vr5hnzp8 280 15 derived derive VBN cord-353298-vr5hnzp8 280 16 from from IN cord-353298-vr5hnzp8 280 17 normal normal JJ cord-353298-vr5hnzp8 280 18 and and CC cord-353298-vr5hnzp8 280 19 demyelinating demyelinating JJ cord-353298-vr5hnzp8 280 20 / / SYM cord-353298-vr5hnzp8 280 21 remyelinating remyelinate VBG cord-353298-vr5hnzp8 280 22 adult adult NN cord-353298-vr5hnzp8 280 23 CNS CNS NNP cord-353298-vr5hnzp8 280 24 , , , cord-353298-vr5hnzp8 280 25 we -PRON- PRP cord-353298-vr5hnzp8 280 26 can can MD cord-353298-vr5hnzp8 280 27 design design VB cord-353298-vr5hnzp8 280 28 future future JJ cord-353298-vr5hnzp8 280 29 experiments experiment NNS cord-353298-vr5hnzp8 280 30 to to TO cord-353298-vr5hnzp8 280 31 determine determine VB cord-353298-vr5hnzp8 280 32 which which WDT cord-353298-vr5hnzp8 280 33 of of IN cord-353298-vr5hnzp8 280 34 the the DT cord-353298-vr5hnzp8 280 35 proliferating proliferate VBG cord-353298-vr5hnzp8 280 36 cells cell NNS cord-353298-vr5hnzp8 280 37 provide provide VBP cord-353298-vr5hnzp8 280 38 new new JJ cord-353298-vr5hnzp8 280 39 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 280 40 in in IN cord-353298-vr5hnzp8 280 41 remyelination remyelination NN cord-353298-vr5hnzp8 280 42 and and CC cord-353298-vr5hnzp8 280 43 which which WDT cord-353298-vr5hnzp8 280 44 factors factor NNS cord-353298-vr5hnzp8 280 45 enhance enhance VBP cord-353298-vr5hnzp8 280 46 this this DT cord-353298-vr5hnzp8 280 47 pathway pathway NN cord-353298-vr5hnzp8 280 48 . . . cord-353298-vr5hnzp8 281 1 Since since IN cord-353298-vr5hnzp8 281 2 we -PRON- PRP cord-353298-vr5hnzp8 281 3 have have VBP cord-353298-vr5hnzp8 281 4 recently recently RB cord-353298-vr5hnzp8 281 5 developed develop VBN cord-353298-vr5hnzp8 281 6 a a DT cord-353298-vr5hnzp8 281 7 similar similar JJ cord-353298-vr5hnzp8 281 8 in in IN cord-353298-vr5hnzp8 281 9 vitro vitro FW cord-353298-vr5hnzp8 281 10 system system NN cord-353298-vr5hnzp8 281 11 from from IN cord-353298-vr5hnzp8 281 12 adult adult NN cord-353298-vr5hnzp8 281 13 human human JJ cord-353298-vr5hnzp8 281 14 CNS CNS NNP cord-353298-vr5hnzp8 281 15 ( ( -LRB- cord-353298-vr5hnzp8 282 1 Dorn Dorn NNP cord-353298-vr5hnzp8 282 2 et et NNP cord-353298-vr5hnzp8 282 3 al al NNP cord-353298-vr5hnzp8 282 4 . . . cord-353298-vr5hnzp8 283 1 , , , cord-353298-vr5hnzp8 283 2 1990 1990 CD cord-353298-vr5hnzp8 283 3 ) ) -RRB- cord-353298-vr5hnzp8 283 4 , , , cord-353298-vr5hnzp8 283 5 such such JJ cord-353298-vr5hnzp8 283 6 experiments experiment NNS cord-353298-vr5hnzp8 283 7 could could MD cord-353298-vr5hnzp8 283 8 also also RB cord-353298-vr5hnzp8 283 9 be be VB cord-353298-vr5hnzp8 283 10 performed perform VBN cord-353298-vr5hnzp8 283 11 with with IN cord-353298-vr5hnzp8 283 12 human human JJ cord-353298-vr5hnzp8 283 13 oligodendrocyte oligodendrocyte NNP cord-353298-vr5hnzp8 283 14 lineage lineage NN cord-353298-vr5hnzp8 283 15 cells cell NNS cord-353298-vr5hnzp8 283 16 . . . cord-353298-vr5hnzp8 284 1 The the DT cord-353298-vr5hnzp8 284 2 study study NN cord-353298-vr5hnzp8 284 3 of of IN cord-353298-vr5hnzp8 284 4 the the DT cord-353298-vr5hnzp8 284 5 growth growth NN cord-353298-vr5hnzp8 284 6 and and CC cord-353298-vr5hnzp8 284 7 differentiation differentiation NN cord-353298-vr5hnzp8 284 8 properties property NNS cord-353298-vr5hnzp8 284 9 of of IN cord-353298-vr5hnzp8 284 10 the the DT cord-353298-vr5hnzp8 284 11 glial glial JJ cord-353298-vr5hnzp8 284 12 cell cell NN cord-353298-vr5hnzp8 284 13 types type NNS cord-353298-vr5hnzp8 284 14 involved involve VBN cord-353298-vr5hnzp8 284 15 in in IN cord-353298-vr5hnzp8 284 16 remyelination remyelination NN cord-353298-vr5hnzp8 284 17 may may MD cord-353298-vr5hnzp8 284 18 lead lead VB cord-353298-vr5hnzp8 284 19 to to IN cord-353298-vr5hnzp8 284 20 the the DT cord-353298-vr5hnzp8 284 21 elaboration elaboration NN cord-353298-vr5hnzp8 284 22 of of IN cord-353298-vr5hnzp8 284 23 strategies strategy NNS cord-353298-vr5hnzp8 284 24 to to TO cord-353298-vr5hnzp8 284 25 promote promote VB cord-353298-vr5hnzp8 284 26 remyelination remyelination NN cord-353298-vr5hnzp8 284 27 in in IN cord-353298-vr5hnzp8 284 28 human human JJ cord-353298-vr5hnzp8 284 29 demyelinating demyelinate VBG cord-353298-vr5hnzp8 284 30 diseases disease NNS cord-353298-vr5hnzp8 284 31 . . . cord-353298-vr5hnzp8 285 1 Mature mature JJ cord-353298-vr5hnzp8 285 2 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 285 3 . . . cord-353298-vr5hnzp8 286 1 Division division NN cord-353298-vr5hnzp8 286 2 following follow VBG cord-353298-vr5hnzp8 286 3 experimental experimental JJ cord-353298-vr5hnzp8 286 4 demyelination demyelination NN cord-353298-vr5hnzp8 286 5 in in IN cord-353298-vr5hnzp8 286 6 adult adult NN cord-353298-vr5hnzp8 286 7 animals animal NNS cord-353298-vr5hnzp8 286 8 Multiple multiple JJ cord-353298-vr5hnzp8 286 9 and and CC cord-353298-vr5hnzp8 286 10 novel novel JJ cord-353298-vr5hnzp8 286 11 specificities specificity NNS cord-353298-vr5hnzp8 286 12 of of IN cord-353298-vr5hnzp8 286 13 monoclonal monoclonal JJ cord-353298-vr5hnzp8 286 14 antibodies antibody NNS cord-353298-vr5hnzp8 286 15 O1,04 O1,04 NNP cord-353298-vr5hnzp8 286 16 and and CC cord-353298-vr5hnzp8 286 17 R r NN cord-353298-vr5hnzp8 286 18 - - HYPH cord-353298-vr5hnzp8 286 19 mAb mab NN cord-353298-vr5hnzp8 286 20 used use VBN cord-353298-vr5hnzp8 286 21 in in IN cord-353298-vr5hnzp8 286 22 the the DT cord-353298-vr5hnzp8 286 23 analysis analysis NN cord-353298-vr5hnzp8 286 24 of of IN cord-353298-vr5hnzp8 286 25 oligodendrocyte oligodendrocyte NNP cord-353298-vr5hnzp8 286 26 development development NNP cord-353298-vr5hnzp8 286 27 Production Production NNP cord-353298-vr5hnzp8 286 28 and and CC cord-353298-vr5hnzp8 286 29 characterization characterization NN cord-353298-vr5hnzp8 286 30 of of IN cord-353298-vr5hnzp8 286 31 high high JJ cord-353298-vr5hnzp8 286 32 titer titer NN cord-353298-vr5hnzp8 286 33 antibodies antibody NNS cord-353298-vr5hnzp8 286 34 to to IN cord-353298-vr5hnzp8 286 35 galactocerebroside galactocerebroside NN cord-353298-vr5hnzp8 286 36 Effects effect NNS cord-353298-vr5hnzp8 286 37 of of IN cord-353298-vr5hnzp8 286 38 acidic acidic JJ cord-353298-vr5hnzp8 286 39 and and CC cord-353298-vr5hnzp8 286 40 basic basic JJ cord-353298-vr5hnzp8 286 41 fibroblast fibroblast NN cord-353298-vr5hnzp8 286 42 growth growth NN cord-353298-vr5hnzp8 286 43 factors factor NNS cord-353298-vr5hnzp8 286 44 on on IN cord-353298-vr5hnzp8 286 45 proliferation proliferation NN cord-353298-vr5hnzp8 286 46 and and CC cord-353298-vr5hnzp8 286 47 maturation maturation NN cord-353298-vr5hnzp8 286 48 of of IN cord-353298-vr5hnzp8 286 49 cultured cultured JJ cord-353298-vr5hnzp8 286 50 rat rat NN cord-353298-vr5hnzp8 286 51 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 286 52 Localization Localization NNP cord-353298-vr5hnzp8 286 53 of of IN cord-353298-vr5hnzp8 286 54 the the DT cord-353298-vr5hnzp8 286 55 glial glial JJ cord-353298-vr5hnzp8 286 56 fibrillary fibrillary JJ cord-353298-vr5hnzp8 286 57 acidic acidic JJ cord-353298-vr5hnzp8 286 58 protein protein NN cord-353298-vr5hnzp8 286 59 in in IN cord-353298-vr5hnzp8 286 60 astrocytes astrocyte NNS cord-353298-vr5hnzp8 286 61 by by IN cord-353298-vr5hnzp8 286 62 immunofluorescence immunofluorescence NN cord-353298-vr5hnzp8 287 1 The the DT cord-353298-vr5hnzp8 287 2 perinodal perinodal NN cord-353298-vr5hnzp8 287 3 astrocyte astrocyte NNP cord-353298-vr5hnzp8 288 1 Ultrastructural ultrastructural JJ cord-353298-vr5hnzp8 288 2 study study NN cord-353298-vr5hnzp8 288 3 of of IN cord-353298-vr5hnzp8 288 4 remyelination remyelination NN cord-353298-vr5hnzp8 288 5 in in IN cord-353298-vr5hnzp8 288 6 an an DT cord-353298-vr5hnzp8 288 7 experimental experimental JJ cord-353298-vr5hnzp8 288 8 lesion lesion NN cord-353298-vr5hnzp8 288 9 in in IN cord-353298-vr5hnzp8 288 10 adult adult NN cord-353298-vr5hnzp8 288 11 cat cat NN cord-353298-vr5hnzp8 288 12 spinal spinal JJ cord-353298-vr5hnzp8 288 13 cord cord NN cord-353298-vr5hnzp8 288 14 Reactive reactive JJ cord-353298-vr5hnzp8 288 15 glial glial JJ cord-353298-vr5hnzp8 288 16 cells cell NNS cord-353298-vr5hnzp8 288 17 in in IN cord-353298-vr5hnzp8 288 18 CNS CNS NNP cord-353298-vr5hnzp8 288 19 demyelination demyelination NN cord-353298-vr5hnzp8 288 20 contain contain VBP cord-353298-vr5hnzp8 288 21 both both DT cord-353298-vr5hnzp8 288 22 GC GC NNP cord-353298-vr5hnzp8 288 23 and and CC cord-353298-vr5hnzp8 288 24 GFAP GFAP NNP cord-353298-vr5hnzp8 289 1 A a DT cord-353298-vr5hnzp8 289 2 monoclonal monoclonal JJ cord-353298-vr5hnzp8 289 3 antibody antibody NN cord-353298-vr5hnzp8 289 4 modulates modulate VBZ cord-353298-vr5hnzp8 289 5 the the DT cord-353298-vr5hnzp8 289 6 interaction interaction NN cord-353298-vr5hnzp8 289 7 of of IN cord-353298-vr5hnzp8 289 8 nerve nerve NN cord-353298-vr5hnzp8 289 9 growth growth NN cord-353298-vr5hnzp8 289 10 factor factor NN cord-353298-vr5hnzp8 289 11 with with IN cord-353298-vr5hnzp8 289 12 PCI2 PCI2 NNP cord-353298-vr5hnzp8 289 13 cells cell NNS cord-353298-vr5hnzp8 289 14 Mitogenic Mitogenic NNP cord-353298-vr5hnzp8 289 15 effect effect NN cord-353298-vr5hnzp8 289 16 of of IN cord-353298-vr5hnzp8 289 17 axolemma axolemma NNP cord-353298-vr5hnzp8 289 18 - - HYPH cord-353298-vr5hnzp8 289 19 enriched enrich VBN cord-353298-vr5hnzp8 289 20 fraction fraction NN cord-353298-vr5hnzp8 289 21 on on IN cord-353298-vr5hnzp8 289 22 cultured cultured JJ cord-353298-vr5hnzp8 289 23 oligodandrocytes oligodandrocyte NNS cord-353298-vr5hnzp8 289 24 Nerve Nerve NNP cord-353298-vr5hnzp8 289 25 growth growth NN cord-353298-vr5hnzp8 289 26 factor factor NN cord-353298-vr5hnzp8 289 27 receptors receptor NNS cord-353298-vr5hnzp8 289 28 on on IN cord-353298-vr5hnzp8 289 29 cultured cultured JJ cord-353298-vr5hnzp8 289 30 rat rat NN cord-353298-vr5hnzp8 289 31 Schwann Schwann NNP cord-353298-vr5hnzp8 289 32 cells cell NNS cord-353298-vr5hnzp8 289 33 Phanotypic Phanotypic NNP cord-353298-vr5hnzp8 289 34 diversity diversity NN cord-353298-vr5hnzp8 289 35 of of IN cord-353298-vr5hnzp8 289 36 glial glial JJ cord-353298-vr5hnzp8 289 37 cells cell NNS cord-353298-vr5hnzp8 289 38 isolated isolate VBN cord-353298-vr5hnzp8 289 39 from from IN cord-353298-vr5hnzp8 289 40 adult adult NN cord-353298-vr5hnzp8 289 41 human human JJ cord-353298-vr5hnzp8 289 42 brain brain NN cord-353298-vr5hnzp8 290 1 The the DT cord-353298-vr5hnzp8 290 2 oligodendrocyte oligodendrocyte JJ cord-353298-vr5hnzp8 290 3 lineage lineage NN cord-353298-vr5hnzp8 290 4 during during IN cord-353298-vr5hnzp8 290 5 myelination myelination NN cord-353298-vr5hnzp8 290 6 and and CC cord-353298-vr5hnzp8 290 7 remyelination remyelination NN cord-353298-vr5hnzp8 291 1 The the DT cord-353298-vr5hnzp8 291 2 differentiation differentiation NN cord-353298-vr5hnzp8 291 3 of of IN cord-353298-vr5hnzp8 291 4 olig olig JJ cord-353298-vr5hnzp8 291 5 ~ ~ NFP cord-353298-vr5hnzp8 291 6 xlen xlen NNP cord-353298-vr5hnzp8 291 7 - - HYPH cord-353298-vr5hnzp8 291 8 drocytes drocytes NNP cord-353298-vr5hnzp8 291 9 in in IN cord-353298-vr5hnzp8 291 10 a a DT cord-353298-vr5hnzp8 291 11 serum serum NN cord-353298-vr5hnzp8 291 12 - - HYPH cord-353298-vr5hnzp8 291 13 free free JJ cord-353298-vr5hnzp8 291 14 hormone hormone NN cord-353298-vr5hnzp8 291 15 - - HYPH cord-353298-vr5hnzp8 291 16 supplemented supplement VBN cord-353298-vr5hnzp8 291 17 medium medium NN cord-353298-vr5hnzp8 291 18 Raft Raft NNP cord-353298-vr5hnzp8 291 19 . . . cord-353298-vr5hnzp8 292 1 1986b 1986b CD cord-353298-vr5hnzp8 292 2 . . . cord-353298-vr5hnzp8 293 1 The the DT cord-353298-vr5hnzp8 293 2 oligodendrocyte oligodendrocyte JJ cord-353298-vr5hnzp8 293 3 - - HYPH cord-353298-vr5hnzp8 293 4 type-2 type-2 NN cord-353298-vr5hnzp8 293 5 astrocyte astrocyte NNP cord-353298-vr5hnzp8 293 6 cell cell NN cord-353298-vr5hnzp8 293 7 lineage lineage NN cord-353298-vr5hnzp8 293 8 is be VBZ cord-353298-vr5hnzp8 293 9 specialized specialize VBN cord-353298-vr5hnzp8 293 10 for for IN cord-353298-vr5hnzp8 293 11 myelination myelination NN cord-353298-vr5hnzp8 294 1 Ameboid Ameboid NNP cord-353298-vr5hnzp8 294 2 microglia microglia NN cord-353298-vr5hnzp8 294 3 as as IN cord-353298-vr5hnzp8 294 4 effectors effector NNS cord-353298-vr5hnzp8 294 5 of of IN cord-353298-vr5hnzp8 294 6 inflammation inflammation NN cord-353298-vr5hnzp8 294 7 in in IN cord-353298-vr5hnzp8 294 8 the the DT cord-353298-vr5hnzp8 294 9 central central JJ cord-353298-vr5hnzp8 294 10 nervous nervous JJ cord-353298-vr5hnzp8 294 11 system system NN cord-353298-vr5hnzp8 295 1 Secreted secrete VBN cord-353298-vr5hnzp8 295 2 peptides peptide NNS cord-353298-vr5hnzp8 295 3 as as IN cord-353298-vr5hnzp8 295 4 regulators regulator NNS cord-353298-vr5hnzp8 295 5 of of IN cord-353298-vr5hnzp8 295 6 neuron neuron NN cord-353298-vr5hnzp8 295 7 - - HYPH cord-353298-vr5hnzp8 295 8 glia glia NNS cord-353298-vr5hnzp8 295 9 and and CC cord-353298-vr5hnzp8 295 10 glia glia NN cord-353298-vr5hnzp8 295 11 - - HYPH cord-353298-vr5hnzp8 295 12 glia glia NN cord-353298-vr5hnzp8 295 13 interactions interaction NNS cord-353298-vr5hnzp8 295 14 in in IN cord-353298-vr5hnzp8 295 15 the the DT cord-353298-vr5hnzp8 295 16 developing develop VBG cord-353298-vr5hnzp8 295 17 nervous nervous JJ cord-353298-vr5hnzp8 295 18 system system NN cord-353298-vr5hnzp8 296 1 In in IN cord-353298-vr5hnzp8 296 2 vivo vivo NN cord-353298-vr5hnzp8 296 3 analysis analysis NN cord-353298-vr5hnzp8 296 4 of of IN cord-353298-vr5hnzp8 296 5 glial glial JJ cord-353298-vr5hnzp8 296 6 cell cell NN cord-353298-vr5hnzp8 296 7 phenotypes phenotype NNS cord-353298-vr5hnzp8 296 8 during during IN cord-353298-vr5hnzp8 296 9 a a DT cord-353298-vr5hnzp8 296 10 viral viral JJ cord-353298-vr5hnzp8 296 11 demyelinating demyelinate VBG cord-353298-vr5hnzp8 296 12 disease disease NN cord-353298-vr5hnzp8 296 13 in in IN cord-353298-vr5hnzp8 296 14 mice mouse NNS cord-353298-vr5hnzp8 296 15 Regeneration Regeneration NNP cord-353298-vr5hnzp8 296 16 of of IN cord-353298-vr5hnzp8 296 17 oligodendroglia oligodendroglia NNP cord-353298-vr5hnzp8 296 18 during during IN cord-353298-vr5hnzp8 296 19 recovery recovery NN cord-353298-vr5hnzp8 296 20 from from IN cord-353298-vr5hnzp8 296 21 demyelinating demyelinate VBG cord-353298-vr5hnzp8 296 22 disease disease NN cord-353298-vr5hnzp8 296 23 Longterm longterm JJ cord-353298-vr5hnzp8 296 24 culture culture NN cord-353298-vr5hnzp8 296 25 of of IN cord-353298-vr5hnzp8 296 26 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 296 27 isolated isolate VBN cord-353298-vr5hnzp8 296 28 from from IN cord-353298-vr5hnzp8 296 29 rat rat NNP cord-353298-vr5hnzp8 296 30 corpus corpus NNP cord-353298-vr5hnzp8 296 31 callosum callosum NN cord-353298-vr5hnzp8 296 32 by by IN cord-353298-vr5hnzp8 296 33 Percoll Percoll NNP cord-353298-vr5hnzp8 296 34 density density NN cord-353298-vr5hnzp8 296 35 gradient gradient NN cord-353298-vr5hnzp8 296 36 Ciliary Ciliary NNP cord-353298-vr5hnzp8 296 37 neurotrophic neurotrophic NN cord-353298-vr5hnzp8 296 38 factor factor NN cord-353298-vr5hnzp8 296 39 ( ( -LRB- cord-353298-vr5hnzp8 296 40 CNTF CNTF NNP cord-353298-vr5hnzp8 296 41 ) ) -RRB- cord-353298-vr5hnzp8 296 42 induces induce VBZ cord-353298-vr5hnzp8 296 43 type-2 type-2 NNP cord-353298-vr5hnzp8 296 44 astrocyte astrocyte JJ cord-353298-vr5hnzp8 296 45 differentiation differentiation NN cord-353298-vr5hnzp8 296 46 in in IN cord-353298-vr5hnzp8 296 47 culture culture NN cord-353298-vr5hnzp8 296 48 Response response NN cord-353298-vr5hnzp8 296 49 of of IN cord-353298-vr5hnzp8 296 50 neonatal neonatal JJ cord-353298-vr5hnzp8 296 51 and and CC cord-353298-vr5hnzp8 296 52 adult adult NN cord-353298-vr5hnzp8 296 53 glial glial JJ cord-353298-vr5hnzp8 296 54 progenitors progenitor NNS cord-353298-vr5hnzp8 296 55 to to IN cord-353298-vr5hnzp8 296 56 neuronal neuronal JJ cord-353298-vr5hnzp8 296 57 cell cell NN cord-353298-vr5hnzp8 296 58 line line NN cord-353298-vr5hnzp8 296 59 - - HYPH cord-353298-vr5hnzp8 296 60 derived derive VBN cord-353298-vr5hnzp8 296 61 mitogens mitogens NNP cord-353298-vr5hnzp8 296 62 Expression expression NN cord-353298-vr5hnzp8 296 63 of of IN cord-353298-vr5hnzp8 296 64 viral viral JJ cord-353298-vr5hnzp8 296 65 and and CC cord-353298-vr5hnzp8 296 66 myelin myelin JJ cord-353298-vr5hnzp8 296 67 gene gene NN cord-353298-vr5hnzp8 296 68 transcripts transcript NNS cord-353298-vr5hnzp8 296 69 in in IN cord-353298-vr5hnzp8 296 70 a a DT cord-353298-vr5hnzp8 296 71 murine murine JJ cord-353298-vr5hnzp8 296 72 demyelinating demyelinate VBG cord-353298-vr5hnzp8 296 73 disease disease NN cord-353298-vr5hnzp8 296 74 caused cause VBN cord-353298-vr5hnzp8 296 75 by by IN cord-353298-vr5hnzp8 296 76 a a DT cord-353298-vr5hnzp8 296 77 coronavirus coronavirus NN cord-353298-vr5hnzp8 296 78 Differential differential NN cord-353298-vr5hnzp8 296 79 exon exon NN cord-353298-vr5hnzp8 296 80 expression expression NN cord-353298-vr5hnzp8 296 81 in in IN cord-353298-vr5hnzp8 296 82 myelin myelin JJ cord-353298-vr5hnzp8 296 83 basic basic JJ cord-353298-vr5hnzp8 296 84 protein protein NN cord-353298-vr5hnzp8 296 85 transcripts transcript NNS cord-353298-vr5hnzp8 296 86 during during IN cord-353298-vr5hnzp8 296 87 CNS CNS NNP cord-353298-vr5hnzp8 296 88 remyelination remyelination NN cord-353298-vr5hnzp8 296 89 Aminomethyl Aminomethyl NNP cord-353298-vr5hnzp8 296 90 coumarin coumarin NN cord-353298-vr5hnzp8 296 91 acetic acetic JJ cord-353298-vr5hnzp8 296 92 acid acid NN cord-353298-vr5hnzp8 296 93 : : : cord-353298-vr5hnzp8 296 94 a a DT cord-353298-vr5hnzp8 296 95 new new JJ cord-353298-vr5hnzp8 296 96 fluorescent fluorescent JJ cord-353298-vr5hnzp8 296 97 labelling labelling NN cord-353298-vr5hnzp8 296 98 agent agent NN cord-353298-vr5hnzp8 296 99 for for IN cord-353298-vr5hnzp8 296 100 proteins protein NNS cord-353298-vr5hnzp8 296 101 Antigen Antigen NNP cord-353298-vr5hnzp8 296 102 expression expression NN cord-353298-vr5hnzp8 296 103 by by IN cord-353298-vr5hnzp8 296 104 glial glial JJ cord-353298-vr5hnzp8 296 105 cells cell NNS cord-353298-vr5hnzp8 296 106 grown grow VBN cord-353298-vr5hnzp8 296 107 in in IN cord-353298-vr5hnzp8 296 108 culture culture NN cord-353298-vr5hnzp8 296 109 Experimental experimental JJ cord-353298-vr5hnzp8 296 110 demyelination demyelination NN cord-353298-vr5hnzp8 296 111 produced produce VBN cord-353298-vr5hnzp8 296 112 by by IN cord-353298-vr5hnzp8 296 113 the the DT cord-353298-vr5hnzp8 296 114 A59 A59 NNP cord-353298-vr5hnzp8 296 115 strain strain NN cord-353298-vr5hnzp8 296 116 of of IN cord-353298-vr5hnzp8 296 117 mouse mouse NN cord-353298-vr5hnzp8 296 118 hepatitis hepatitis NN cord-353298-vr5hnzp8 296 119 virus virus NN cord-353298-vr5hnzp8 296 120 Monoclonal monoclonal JJ cord-353298-vr5hnzp8 296 121 antibodies antibody NNS cord-353298-vr5hnzp8 296 122 to to IN cord-353298-vr5hnzp8 296 123 gel gel NN cord-353298-vr5hnzp8 296 124 - - HYPH cord-353298-vr5hnzp8 296 125 excised excise VBN cord-353298-vr5hnzp8 296 126 glial glial JJ cord-353298-vr5hnzp8 296 127 filament filament NN cord-353298-vr5hnzp8 296 128 protein protein NN cord-353298-vr5hnzp8 296 129 and and CC cord-353298-vr5hnzp8 296 130 their -PRON- PRP$ cord-353298-vr5hnzp8 296 131 reactivities reactivity NNS cord-353298-vr5hnzp8 296 132 with with IN cord-353298-vr5hnzp8 296 133 other other JJ cord-353298-vr5hnzp8 296 134 intermediate intermediate JJ cord-353298-vr5hnzp8 296 135 filament filament NN cord-353298-vr5hnzp8 296 136 proteins protein NNS cord-353298-vr5hnzp8 297 1 Type-2 type-2 NN cord-353298-vr5hnzp8 298 1 astrocyte astrocyte NNP cord-353298-vr5hnzp8 298 2 development development NN cord-353298-vr5hnzp8 298 3 in in IN cord-353298-vr5hnzp8 298 4 rat rat NN cord-353298-vr5hnzp8 298 5 brain brain NN cord-353298-vr5hnzp8 298 6 cultures culture NNS cord-353298-vr5hnzp8 298 7 is be VBZ cord-353298-vr5hnzp8 298 8 initiated initiate VBN cord-353298-vr5hnzp8 298 9 by by IN cord-353298-vr5hnzp8 298 10 a a DT cord-353298-vr5hnzp8 298 11 CNTFlike cntflike NN cord-353298-vr5hnzp8 298 12 protein protein NN cord-353298-vr5hnzp8 298 13 produced produce VBN cord-353298-vr5hnzp8 298 14 by by IN cord-353298-vr5hnzp8 298 15 type-1 type-1 NN cord-353298-vr5hnzp8 298 16 astrocytes astrocyte NNS cord-353298-vr5hnzp8 299 1 An an DT cord-353298-vr5hnzp8 299 2 autoradiographic autoradiographic JJ cord-353298-vr5hnzp8 299 3 study study NN cord-353298-vr5hnzp8 299 4 of of IN cord-353298-vr5hnzp8 299 5 cellular cellular JJ cord-353298-vr5hnzp8 299 6 proliferation proliferation NN cord-353298-vr5hnzp8 299 7 in in IN cord-353298-vr5hnzp8 299 8 remyelination remyelination NN cord-353298-vr5hnzp8 299 9 of of IN cord-353298-vr5hnzp8 299 10 the the DT cord-353298-vr5hnzp8 299 11 central central JJ cord-353298-vr5hnzp8 299 12 nervous nervous JJ cord-353298-vr5hnzp8 299 13 system system NN cord-353298-vr5hnzp8 299 14 Demyelinating Demyelinating NNP cord-353298-vr5hnzp8 299 15 Disease disease NN cord-353298-vr5hnzp8 299 16 : : : cord-353298-vr5hnzp8 300 1 Basic basic JJ cord-353298-vr5hnzp8 300 2 and and CC cord-353298-vr5hnzp8 300 3 Clinical Clinical NNP cord-353298-vr5hnzp8 300 4 Electrophysiology Electrophysiology NNP cord-353298-vr5hnzp8 300 5 Can Can MD cord-353298-vr5hnzp8 300 6 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 300 7 attached attach VBN cord-353298-vr5hnzp8 300 8 to to IN cord-353298-vr5hnzp8 300 9 myelin myelin NN cord-353298-vr5hnzp8 300 10 proliferate proliferate VB cord-353298-vr5hnzp8 301 1 Radioautographic radioautographic JJ cord-353298-vr5hnzp8 301 2 evidence evidence NN cord-353298-vr5hnzp8 301 3 for for IN cord-353298-vr5hnzp8 301 4 slow slow JJ cord-353298-vr5hnzp8 301 5 astrocyte astrocyte JJ cord-353298-vr5hnzp8 301 6 turnover turnover NN cord-353298-vr5hnzp8 301 7 and and CC cord-353298-vr5hnzp8 301 8 modest modest JJ cord-353298-vr5hnzp8 301 9 oligodendrocyte oligodendrocyte JJ cord-353298-vr5hnzp8 301 10 production production NN cord-353298-vr5hnzp8 301 11 in in IN cord-353298-vr5hnzp8 301 12 the the DT cord-353298-vr5hnzp8 301 13 corpus corpus NNP cord-353298-vr5hnzp8 301 14 callosum callosum NN cord-353298-vr5hnzp8 301 15 of of IN cord-353298-vr5hnzp8 301 16 adult adult NN cord-353298-vr5hnzp8 301 17 mice mouse NNS cord-353298-vr5hnzp8 301 18 infused infuse VBN cord-353298-vr5hnzp8 301 19 with with IN cord-353298-vr5hnzp8 301 20 [ [ -LRB- cord-353298-vr5hnzp8 301 21 3H]thymidine 3h]thymidine CD cord-353298-vr5hnzp8 301 22 Fibroblast Fibroblast NNP cord-353298-vr5hnzp8 301 23 growth growth NN cord-353298-vr5hnzp8 301 24 factor factor NN cord-353298-vr5hnzp8 301 25 blocks block VBZ cord-353298-vr5hnzp8 301 26 myelin myelin JJ cord-353298-vr5hnzp8 301 27 basic basic JJ cord-353298-vr5hnzp8 301 28 protein protein NN cord-353298-vr5hnzp8 301 29 gene gene NN cord-353298-vr5hnzp8 301 30 expression expression NN cord-353298-vr5hnzp8 301 31 in in IN cord-353298-vr5hnzp8 301 32 differentiating differentiate VBG cord-353298-vr5hnzp8 301 33 O-2A O-2A NNP cord-353298-vr5hnzp8 301 34 glial glial JJ cord-353298-vr5hnzp8 301 35 progenitor progenitor NN cord-353298-vr5hnzp8 301 36 cells cell NNS cord-353298-vr5hnzp8 301 37 Insulin insulin NN cord-353298-vr5hnzp8 301 38 - - HYPH cord-353298-vr5hnzp8 301 39 like like JJ cord-353298-vr5hnzp8 301 40 growth growth NN cord-353298-vr5hnzp8 301 41 factor factor NN cord-353298-vr5hnzp8 301 42 I -PRON- PRP cord-353298-vr5hnzp8 301 43 promotes promote VBZ cord-353298-vr5hnzp8 301 44 ceil ceil NN cord-353298-vr5hnzp8 301 45 proliferation proliferation NN cord-353298-vr5hnzp8 301 46 and and CC cord-353298-vr5hnzp8 301 47 oligodendroglial oligodendroglial JJ cord-353298-vr5hnzp8 301 48 commitment commitment NN cord-353298-vr5hnzp8 301 49 in in IN cord-353298-vr5hnzp8 301 50 rat rat NN cord-353298-vr5hnzp8 301 51 glial glial JJ cord-353298-vr5hnzp8 301 52 progenitor progenitor NN cord-353298-vr5hnzp8 301 53 cells cell NNS cord-353298-vr5hnzp8 301 54 developing develop VBG cord-353298-vr5hnzp8 301 55 in in IN cord-353298-vr5hnzp8 301 56 vitro vitro FW cord-353298-vr5hnzp8 301 57 Insulinlike Insulinlike NNP cord-353298-vr5hnzp8 301 58 growth growth NN cord-353298-vr5hnzp8 301 59 factor factor NN cord-353298-vr5hnzp8 301 60 I I NNP cord-353298-vr5hnzp8 301 61 / / SYM cord-353298-vr5hnzp8 301 62 somatomedin somatomedin NNP cord-353298-vr5hnzp8 301 63 C C NNP cord-353298-vr5hnzp8 301 64 : : : cord-353298-vr5hnzp8 301 65 a a DT cord-353298-vr5hnzp8 301 66 potent potent JJ cord-353298-vr5hnzp8 301 67 inducer inducer NN cord-353298-vr5hnzp8 301 68 of of IN cord-353298-vr5hnzp8 301 69 oligodendrocyte oligodendrocyte NNP cord-353298-vr5hnzp8 301 70 development development NNP cord-353298-vr5hnzp8 302 1 A a DT cord-353298-vr5hnzp8 302 2 quantitative quantitative JJ cord-353298-vr5hnzp8 302 3 immunohistochemical immunohistochemical JJ cord-353298-vr5hnzp8 302 4 study study NN cord-353298-vr5hnzp8 302 5 of of IN cord-353298-vr5hnzp8 302 6 macroglial macroglial JJ cord-353298-vr5hnzp8 302 7 cell cell NN cord-353298-vr5hnzp8 302 8 development development NN cord-353298-vr5hnzp8 302 9 in in IN cord-353298-vr5hnzp8 302 10 the the DT cord-353298-vr5hnzp8 302 11 rat rat NN cord-353298-vr5hnzp8 302 12 optic optic JJ cord-353298-vr5hnzp8 302 13 nerve nerve NN cord-353298-vr5hnzp8 302 14 : : : cord-353298-vr5hnzp8 302 15 in in IN cord-353298-vr5hnzp8 302 16 vivo vivo NN cord-353298-vr5hnzp8 302 17 evidence evidence NN cord-353298-vr5hnzp8 302 18 for for IN cord-353298-vr5hnzp8 302 19 two two CD cord-353298-vr5hnzp8 302 20 distinct distinct JJ cord-353298-vr5hnzp8 302 21 astrocyte astrocyte NNP cord-353298-vr5hnzp8 302 22 lineages lineage NNS cord-353298-vr5hnzp8 302 23 Injury injury NN cord-353298-vr5hnzp8 302 24 - - HYPH cord-353298-vr5hnzp8 302 25 induced induce VBN cord-353298-vr5hnzp8 302 26 neuronotrophic neuronotrophic JJ cord-353298-vr5hnzp8 302 27 activity activity NN cord-353298-vr5hnzp8 302 28 in in IN cord-353298-vr5hnzp8 302 29 adult adult NN cord-353298-vr5hnzp8 302 30 rat rat NN cord-353298-vr5hnzp8 302 31 brain brain NN cord-353298-vr5hnzp8 302 32 : : : cord-353298-vr5hnzp8 302 33 correlation correlation NN cord-353298-vr5hnzp8 302 34 with with IN cord-353298-vr5hnzp8 302 35 survival survival NN cord-353298-vr5hnzp8 302 36 of of IN cord-353298-vr5hnzp8 302 37 delayed delay VBN cord-353298-vr5hnzp8 302 38 implants implant NNS cord-353298-vr5hnzp8 302 39 in in IN cord-353298-vr5hnzp8 302 40 the the DT cord-353298-vr5hnzp8 302 41 wound wound NN cord-353298-vr5hnzp8 302 42 cavity cavity NN cord-353298-vr5hnzp8 302 43 Platelet platelet NN cord-353298-vr5hnzp8 302 44 - - HYPH cord-353298-vr5hnzp8 302 45 derived derive VBN cord-353298-vr5hnzp8 302 46 growth growth NN cord-353298-vr5hnzp8 302 47 factor factor NN cord-353298-vr5hnzp8 302 48 promotes promote VBZ cord-353298-vr5hnzp8 302 49 division division NN cord-353298-vr5hnzp8 302 50 and and CC cord-353298-vr5hnzp8 302 51 motility motility NN cord-353298-vr5hnzp8 302 52 and and CC cord-353298-vr5hnzp8 302 53 inhibits inhibit VBZ cord-353298-vr5hnzp8 302 54 premature premature JJ cord-353298-vr5hnzp8 302 55 differentiation differentiation NN cord-353298-vr5hnzp8 302 56 of of IN cord-353298-vr5hnzp8 302 57 the the DT cord-353298-vr5hnzp8 302 58 oligodendrocyte oligodendrocyte NNP cord-353298-vr5hnzp8 303 1 type-2 type-2 NN cord-353298-vr5hnzp8 304 1 astrocyte astrocyte NNP cord-353298-vr5hnzp8 305 1 progenitor progenitor JJ cord-353298-vr5hnzp8 305 2 cell cell NN cord-353298-vr5hnzp8 305 3 Electron Electron NNP cord-353298-vr5hnzp8 305 4 microscopic microscopic JJ cord-353298-vr5hnzp8 305 5 features feature NNS cord-353298-vr5hnzp8 305 6 of of IN cord-353298-vr5hnzp8 305 7 multiple multiple JJ cord-353298-vr5hnzp8 305 8 sclerosis sclerosis NN cord-353298-vr5hnzp8 305 9 lesions lesion NNS cord-353298-vr5hnzp8 305 10 Continuous continuous JJ cord-353298-vr5hnzp8 305 11 breakdown breakdown NN cord-353298-vr5hnzp8 305 12 and and CC cord-353298-vr5hnzp8 305 13 regeneration regeneration NN cord-353298-vr5hnzp8 305 14 of of IN cord-353298-vr5hnzp8 305 15 myelin myelin NN cord-353298-vr5hnzp8 305 16 in in IN cord-353298-vr5hnzp8 305 17 progressive progressive JJ cord-353298-vr5hnzp8 305 18 multiple multiple JJ cord-353298-vr5hnzp8 305 19 sclerosis sclerosis NN cord-353298-vr5hnzp8 305 20 plaques plaque NNS cord-353298-vr5hnzp8 306 1 Thy-1 Thy-1 NNP cord-353298-vr5hnzp8 306 2 antigen antigen NN cord-353298-vr5hnzp8 306 3 on on IN cord-353298-vr5hnzp8 306 4 astrocytes astrocyte NNS cord-353298-vr5hnzp8 306 5 in in IN cord-353298-vr5hnzp8 306 6 long long JJ cord-353298-vr5hnzp8 306 7 - - HYPH cord-353298-vr5hnzp8 306 8 term term NN cord-353298-vr5hnzp8 306 9 cultures culture NNS cord-353298-vr5hnzp8 306 10 of of IN cord-353298-vr5hnzp8 306 11 rat rat NN cord-353298-vr5hnzp8 306 12 central central JJ cord-353298-vr5hnzp8 306 13 nervous nervous JJ cord-353298-vr5hnzp8 306 14 system system NN cord-353298-vr5hnzp8 306 15 Glial glial JJ cord-353298-vr5hnzp8 306 16 cell cell NN cord-353298-vr5hnzp8 306 17 diversification diversification NN cord-353298-vr5hnzp8 306 18 in in IN cord-353298-vr5hnzp8 306 19 the the DT cord-353298-vr5hnzp8 306 20 rat rat NN cord-353298-vr5hnzp8 306 21 optic optic JJ cord-353298-vr5hnzp8 306 22 nerve nerve NN cord-353298-vr5hnzp8 306 23 Galactocerebroside Galactocerebroside NNP cord-353298-vr5hnzp8 306 24 is be VBZ cord-353298-vr5hnzp8 306 25 a a DT cord-353298-vr5hnzp8 306 26 specific specific JJ cord-353298-vr5hnzp8 306 27 cell cell NN cord-353298-vr5hnzp8 306 28 - - HYPH cord-353298-vr5hnzp8 306 29 surface surface NN cord-353298-vr5hnzp8 306 30 antigenic antigenic JJ cord-353298-vr5hnzp8 306 31 marker marker NN cord-353298-vr5hnzp8 306 32 for for IN cord-353298-vr5hnzp8 306 33 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 306 34 in in IN cord-353298-vr5hnzp8 306 35 culture culture NN cord-353298-vr5hnzp8 306 36 Two two CD cord-353298-vr5hnzp8 306 37 types type NNS cord-353298-vr5hnzp8 306 38 of of IN cord-353298-vr5hnzp8 306 39 astrocytes astrocyte NNS cord-353298-vr5hnzp8 306 40 in in IN cord-353298-vr5hnzp8 306 41 cultures culture NNS cord-353298-vr5hnzp8 306 42 of of IN cord-353298-vr5hnzp8 306 43 developing develop VBG cord-353298-vr5hnzp8 306 44 rat rat NN cord-353298-vr5hnzp8 306 45 white white JJ cord-353298-vr5hnzp8 306 46 matter matter NN cord-353298-vr5hnzp8 306 47 : : : cord-353298-vr5hnzp8 306 48 differences difference NNS cord-353298-vr5hnzp8 306 49 in in IN cord-353298-vr5hnzp8 306 50 morphology morphology NN cord-353298-vr5hnzp8 306 51 , , , cord-353298-vr5hnzp8 306 52 surface surface NN cord-353298-vr5hnzp8 306 53 gangliosides ganglioside NNS cord-353298-vr5hnzp8 306 54 , , , cord-353298-vr5hnzp8 306 55 and and CC cord-353298-vr5hnzp8 306 56 growth growth NN cord-353298-vr5hnzp8 306 57 characteristics characteristic NNS cord-353298-vr5hnzp8 307 1 A a DT cord-353298-vr5hnzp8 307 2 glial glial JJ cord-353298-vr5hnzp8 307 3 progenitor progenitor NN cord-353298-vr5hnzp8 307 4 cell cell NN cord-353298-vr5hnzp8 307 5 that that WDT cord-353298-vr5hnzp8 307 6 develops develop VBZ cord-353298-vr5hnzp8 307 7 in in IN cord-353298-vr5hnzp8 307 8 vitro vitro FW cord-353298-vr5hnzp8 307 9 into into IN cord-353298-vr5hnzp8 307 10 an an DT cord-353298-vr5hnzp8 307 11 astrocyte astrocyte NN cord-353298-vr5hnzp8 307 12 or or CC cord-353298-vr5hnzp8 307 13 an an DT cord-353298-vr5hnzp8 307 14 oligodendrocyte oligodendrocyte JJ cord-353298-vr5hnzp8 307 15 depending depend VBG cord-353298-vr5hnzp8 307 16 on on IN cord-353298-vr5hnzp8 307 17 culture culture NN cord-353298-vr5hnzp8 307 18 medium medium NN cord-353298-vr5hnzp8 307 19 Two two CD cord-353298-vr5hnzp8 307 20 glial glial JJ cord-353298-vr5hnzp8 307 21 cell cell NN cord-353298-vr5hnzp8 307 22 lineages lineage NNS cord-353298-vr5hnzp8 307 23 diverge diverge VBP cord-353298-vr5hnzp8 307 24 prenatally prenatally RB cord-353298-vr5hnzp8 307 25 in in IN cord-353298-vr5hnzp8 307 26 rat rat NN cord-353298-vr5hnzp8 307 27 optic optic JJ cord-353298-vr5hnzp8 307 28 nerve nerve NN cord-353298-vr5hnzp8 307 29 Platelet platelet NN cord-353298-vr5hnzp8 307 30 - - HYPH cord-353298-vr5hnzp8 307 31 derived derive VBN cord-353298-vr5hnzp8 307 32 growth growth NN cord-353298-vr5hnzp8 307 33 factor factor NN cord-353298-vr5hnzp8 307 34 from from IN cord-353298-vr5hnzp8 307 35 astrocytes astrocyte NNS cord-353298-vr5hnzp8 307 36 drives drive VBZ cord-353298-vr5hnzp8 307 37 the the DT cord-353298-vr5hnzp8 307 38 clock clock NN cord-353298-vr5hnzp8 307 39 that that WDT cord-353298-vr5hnzp8 307 40 times times NNP cord-353298-vr5hnzp8 307 41 oligodendrocyte oligodendrocyte NNP cord-353298-vr5hnzp8 307 42 development development NN cord-353298-vr5hnzp8 307 43 in in IN cord-353298-vr5hnzp8 307 44 culture culture NN cord-353298-vr5hnzp8 307 45 Morphology morphology NN cord-353298-vr5hnzp8 307 46 of of IN cord-353298-vr5hnzp8 307 47 myelin myelin NN cord-353298-vr5hnzp8 307 48 and and CC cord-353298-vr5hnzp8 307 49 myelination myelination NN cord-353298-vr5hnzp8 308 1 Remyelination remyelination NN cord-353298-vr5hnzp8 308 2 in in IN cord-353298-vr5hnzp8 308 3 multiple multiple JJ cord-353298-vr5hnzp8 308 4 sclerosis sclerosis NN cord-353298-vr5hnzp8 308 5 : : : cord-353298-vr5hnzp8 308 6 immunopathologic immunopathologic NNP cord-353298-vr5hnzp8 308 7 considerations consideration NNS cord-353298-vr5hnzp8 308 8 Induction Induction NNP cord-353298-vr5hnzp8 308 9 of of IN cord-353298-vr5hnzp8 308 10 oligodendrocyte oligodendrocyte NNP cord-353298-vr5hnzp8 308 11 proliferation proliferation NN cord-353298-vr5hnzp8 308 12 and and CC cord-353298-vr5hnzp8 308 13 remyelination remyelination NN cord-353298-vr5hnzp8 308 14 after after IN cord-353298-vr5hnzp8 308 15 chronic chronic JJ cord-353298-vr5hnzp8 308 16 demyelination demyelination NN cord-353298-vr5hnzp8 308 17 . . . cord-353298-vr5hnzp8 309 1 Relevance relevance NN cord-353298-vr5hnzp8 309 2 to to IN cord-353298-vr5hnzp8 309 3 multiple multiple JJ cord-353298-vr5hnzp8 309 4 sclerosis sclerosis NN cord-353298-vr5hnzp8 309 5 Development Development NNP cord-353298-vr5hnzp8 309 6 of of IN cord-353298-vr5hnzp8 309 7 oligodeodrocytes oligodeodrocyte NNS cord-353298-vr5hnzp8 309 8 and and CC cord-353298-vr5hnzp8 309 9 Schwann Schwann NNP cord-353298-vr5hnzp8 309 10 cells cell NNS cord-353298-vr5hnzp8 309 11 studied study VBD cord-353298-vr5hnzp8 309 12 with with IN cord-353298-vr5hnzp8 309 13 a a DT cord-353298-vr5hnzp8 309 14 monoclonal monoclonal JJ cord-353298-vr5hnzp8 309 15 antibody antibody NN cord-353298-vr5hnzp8 309 16 against against IN cord-353298-vr5hnzp8 309 17 galactocerebroside galactocerebroside NN cord-353298-vr5hnzp8 309 18 Microglia Microglia NNP cord-353298-vr5hnzp8 309 19 and and CC cord-353298-vr5hnzp8 309 20 microglia microglia NN cord-353298-vr5hnzp8 309 21 - - HYPH cord-353298-vr5hnzp8 309 22 derived derive VBN cord-353298-vr5hnzp8 309 23 brain brain NN cord-353298-vr5hnzp8 309 24 macrophages macrophage NNS cord-353298-vr5hnzp8 309 25 in in IN cord-353298-vr5hnzp8 309 26 culture culture NN cord-353298-vr5hnzp8 309 27 : : : cord-353298-vr5hnzp8 309 28 generation generation NN cord-353298-vr5hnzp8 309 29 from from IN cord-353298-vr5hnzp8 309 30 axotomized axotomize VBN cord-353298-vr5hnzp8 309 31 rat rat NN cord-353298-vr5hnzp8 309 32 facial facial JJ cord-353298-vr5hnzp8 309 33 nuclei nucleus NNS cord-353298-vr5hnzp8 309 34 , , , cord-353298-vr5hnzp8 309 35 identification identification NN cord-353298-vr5hnzp8 309 36 and and CC cord-353298-vr5hnzp8 309 37 characterization characterization NN cord-353298-vr5hnzp8 309 38 in in IN cord-353298-vr5hnzp8 309 39 vitro vitro FW cord-353298-vr5hnzp8 309 40 Physiological physiological JJ cord-353298-vr5hnzp8 309 41 basis basis NN cord-353298-vr5hnzp8 309 42 of of IN cord-353298-vr5hnzp8 309 43 conduction conduction NN cord-353298-vr5hnzp8 309 44 in in IN cord-353298-vr5hnzp8 309 45 myelinated myelinated JJ cord-353298-vr5hnzp8 309 46 nerve nerve NN cord-353298-vr5hnzp8 309 47 Epidermal epidermal JJ cord-353298-vr5hnzp8 309 48 growth growth NN cord-353298-vr5hnzp8 309 49 factor factor NN cord-353298-vr5hnzp8 309 50 inhibits inhibit VBZ cord-353298-vr5hnzp8 309 51 the the DT cord-353298-vr5hnzp8 309 52 expression expression NN cord-353298-vr5hnzp8 309 53 of of IN cord-353298-vr5hnzp8 309 54 myelin myelin JJ cord-353298-vr5hnzp8 309 55 basic basic JJ cord-353298-vr5hnzp8 309 56 protein protein NN cord-353298-vr5hnzp8 309 57 in in IN cord-353298-vr5hnzp8 309 58 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 309 59 Monoclonal monoclonal JJ cord-353298-vr5hnzp8 309 60 antibodies antibody NNS cord-353298-vr5hnzp8 309 61 ( ( -LRB- cord-353298-vr5hnzp8 309 62 01 01 CD cord-353298-vr5hnzp8 309 63 to to IN cord-353298-vr5hnzp8 309 64 04 04 CD cord-353298-vr5hnzp8 309 65 ) ) -RRB- cord-353298-vr5hnzp8 309 66 to to IN cord-353298-vr5hnzp8 309 67 oligodendrocyte oligodendrocyte NNP cord-353298-vr5hnzp8 309 68 cell cell NN cord-353298-vr5hnzp8 309 69 surfaces surface NNS cord-353298-vr5hnzp8 309 70 : : : cord-353298-vr5hnzp8 309 71 an an DT cord-353298-vr5hnzp8 309 72 immunocytological immunocytological JJ cord-353298-vr5hnzp8 309 73 study study NN cord-353298-vr5hnzp8 309 74 in in IN cord-353298-vr5hnzp8 309 75 the the DT cord-353298-vr5hnzp8 309 76 central central JJ cord-353298-vr5hnzp8 309 77 nervous nervous JJ cord-353298-vr5hnzp8 309 78 system system NN cord-353298-vr5hnzp8 309 79 Isolation isolation NN cord-353298-vr5hnzp8 309 80 of of IN cord-353298-vr5hnzp8 309 81 coronavirus coronavirus NN cord-353298-vr5hnzp8 309 82 envelope envelope NN cord-353298-vr5hnzp8 309 83 glycoproteins glycoprotein NNS cord-353298-vr5hnzp8 309 84 and and CC cord-353298-vr5hnzp8 309 85 interaction interaction NN cord-353298-vr5hnzp8 309 86 with with IN cord-353298-vr5hnzp8 309 87 the the DT cord-353298-vr5hnzp8 309 88 viral viral JJ cord-353298-vr5hnzp8 309 89 nucleocapsid nucleocapsid NN cord-353298-vr5hnzp8 309 90 Cells cell NNS cord-353298-vr5hnzp8 309 91 positive positive JJ cord-353298-vr5hnzp8 309 92 for for IN cord-353298-vr5hnzp8 309 93 the the DT cord-353298-vr5hnzp8 309 94 04 04 CD cord-353298-vr5hnzp8 309 95 surface surface NN cord-353298-vr5hnzp8 309 96 antigen antigen NN cord-353298-vr5hnzp8 309 97 isolated isolate VBN cord-353298-vr5hnzp8 309 98 by by IN cord-353298-vr5hnzp8 309 99 cell cell NN cord-353298-vr5hnzp8 309 100 sorting sorting NN cord-353298-vr5hnzp8 309 101 are be VBP cord-353298-vr5hnzp8 309 102 able able JJ cord-353298-vr5hnzp8 309 103 to to TO cord-353298-vr5hnzp8 309 104 differentiate differentiate VB cord-353298-vr5hnzp8 309 105 into into IN cord-353298-vr5hnzp8 309 106 astrocytes astrocyte NNS cord-353298-vr5hnzp8 309 107 or or CC cord-353298-vr5hnzp8 309 108 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 309 109 Identification identification NN cord-353298-vr5hnzp8 309 110 of of IN cord-353298-vr5hnzp8 309 111 an an DT cord-353298-vr5hnzp8 309 112 adult adult NN cord-353298-vr5hnzp8 309 113 - - HYPH cord-353298-vr5hnzp8 309 114 specific specific JJ cord-353298-vr5hnzp8 309 115 glial glial JJ cord-353298-vr5hnzp8 309 116 progenitor progenitor NN cord-353298-vr5hnzp8 309 117 cell cell NN cord-353298-vr5hnzp8 310 1 The the DT cord-353298-vr5hnzp8 310 2 biology biology NN cord-353298-vr5hnzp8 310 3 of of IN cord-353298-vr5hnzp8 310 4 the the DT cord-353298-vr5hnzp8 310 5 oligodendrocyte oligodendrocyte JJ cord-353298-vr5hnzp8 310 6 Evidence evidence NN cord-353298-vr5hnzp8 310 7 that that IN cord-353298-vr5hnzp8 310 8 axons axon NNS cord-353298-vr5hnzp8 310 9 are be VBP cord-353298-vr5hnzp8 310 10 mitogenic mitogenic JJ cord-353298-vr5hnzp8 310 11 for for IN cord-353298-vr5hnzp8 310 12 oligodendrocytes oligodendrocyte NNS cord-353298-vr5hnzp8 310 13 isolated isolate VBN cord-353298-vr5hnzp8 310 14 from from IN cord-353298-vr5hnzp8 310 15 adult adult NN cord-353298-vr5hnzp8 310 16 animals animal NNS cord-353298-vr5hnzp8 310 17 Acute acute JJ cord-353298-vr5hnzp8 310 18 and and CC cord-353298-vr5hnzp8 310 19 subacute subacute JJ cord-353298-vr5hnzp8 310 20 demyelination demyelination NN cord-353298-vr5hnzp8 310 21 induced induce VBN cord-353298-vr5hnzp8 310 22 by by IN cord-353298-vr5hnzp8 310 23 mouse mouse NNP cord-353298-vr5hnzp8 310 24 hepatitis hepatitis NNP cord-353298-vr5hnzp8 310 25 virus virus NN cord-353298-vr5hnzp8 310 26 strain strain VBP cord-353298-vr5hnzp8 310 27 A59 A59 NNP cord-353298-vr5hnzp8 310 28 in in IN cord-353298-vr5hnzp8 310 29 C3H c3h CD cord-353298-vr5hnzp8 310 30 mice mouse NNS cord-353298-vr5hnzp8 311 1 Cultured cultured JJ cord-353298-vr5hnzp8 311 2 rat rat NN cord-353298-vr5hnzp8 311 3 Schwann Schwann NNP cord-353298-vr5hnzp8 311 4 cells cell NNS cord-353298-vr5hnzp8 311 5 express express VBP cord-353298-vr5hnzp8 311 6 low low JJ cord-353298-vr5hnzp8 311 7 aliinity aliinity NN cord-353298-vr5hnzp8 311 8 receptors receptor NNS cord-353298-vr5hnzp8 311 9 for for IN cord-353298-vr5hnzp8 311 10 nerve nerve NN cord-353298-vr5hnzp8 311 11 growth growth NN cord-353298-vr5hnzp8 311 12 factor factor NN cord-353298-vr5hnzp8 311 13 Growth growth NN cord-353298-vr5hnzp8 311 14 factors factor NNS cord-353298-vr5hnzp8 311 15 for for IN cord-353298-vr5hnzp8 311 16 human human JJ cord-353298-vr5hnzp8 311 17 glial glial JJ cord-353298-vr5hnzp8 311 18 cells cell NNS cord-353298-vr5hnzp8 311 19 in in IN cord-353298-vr5hnzp8 311 20 culture culture NN cord-353298-vr5hnzp8 312 1 We -PRON- PRP cord-353298-vr5hnzp8 312 2 thank thank VBP cord-353298-vr5hnzp8 312 3 Christine Christine NNP cord-353298-vr5hnzp8 312 4 Cardellechio Cardellechio NNP cord-353298-vr5hnzp8 312 5 , , , cord-353298-vr5hnzp8 312 6 Ray Ray NNP cord-353298-vr5hnzp8 312 7 Rusten Rusten NNP cord-353298-vr5hnzp8 312 8 , , , cord-353298-vr5hnzp8 312 9 and and CC cord-353298-vr5hnzp8 312 10 Susan Susan NNP cord-353298-vr5hnzp8 312 11 Wetherall Wetherall NNP cord-353298-vr5hnzp8 312 12 for for IN cord-353298-vr5hnzp8 312 13 excellent excellent JJ cord-353298-vr5hnzp8 312 14 technical technical JJ cord-353298-vr5hnzp8 312 15 assistance assistance NN cord-353298-vr5hnzp8 312 16 . . . cord-353298-vr5hnzp8 313 1 As as IN cord-353298-vr5hnzp8 313 2 mentioned mention VBN cord-353298-vr5hnzp8 313 3 in in IN cord-353298-vr5hnzp8 313 4 the the DT cord-353298-vr5hnzp8 313 5 text text NN cord-353298-vr5hnzp8 313 6 , , , cord-353298-vr5hnzp8 313 7 we -PRON- PRP cord-353298-vr5hnzp8 313 8 are be VBP cord-353298-vr5hnzp8 313 9 very very RB cord-353298-vr5hnzp8 313 10 grateful grateful JJ cord-353298-vr5hnzp8 313 11 to to IN cord-353298-vr5hnzp8 313 12 our -PRON- PRP$ cord-353298-vr5hnzp8 313 13 colleagues colleague NNS cord-353298-vr5hnzp8 313 14 who who WP cord-353298-vr5hnzp8 313 15 donated donate VBD cord-353298-vr5hnzp8 313 16 antibodies antibody NNS cord-353298-vr5hnzp8 313 17 used use VBN cord-353298-vr5hnzp8 313 18 in in IN cord-353298-vr5hnzp8 313 19 this this DT cord-353298-vr5hnzp8 313 20 study study NN cord-353298-vr5hnzp8 313 21 . . . cord-353298-vr5hnzp8 314 1 We -PRON- PRP cord-353298-vr5hnzp8 314 2 also also RB cord-353298-vr5hnzp8 314 3 thank thank VBP cord-353298-vr5hnzp8 314 4 Craig Craig NNP cord-353298-vr5hnzp8 314 5 Jordan Jordan NNP cord-353298-vr5hnzp8 314 6 and and CC cord-353298-vr5hnzp8 314 7 Brynmor Brynmor NNP cord-353298-vr5hnzp8 314 8 Watldns Watldns NNP cord-353298-vr5hnzp8 314 9 for for IN cord-353298-vr5hnzp8 314 10 helpful helpful JJ cord-353298-vr5hnzp8 314 11 comments comment NNS cord-353298-vr5hnzp8 314 12 on on IN cord-353298-vr5hnzp8 314 13 the the DT cord-353298-vr5hnzp8 314 14 manuscript manuscript NN cord-353298-vr5hnzp8 314 15 . . . cord-353298-vr5hnzp8 315 1 This this DT cord-353298-vr5hnzp8 315 2 work work NN cord-353298-vr5hnzp8 315 3 was be VBD cord-353298-vr5hnzp8 315 4 supported support VBN cord-353298-vr5hnzp8 315 5 in in IN cord-353298-vr5hnzp8 315 6 part part NN cord-353298-vr5hnzp8 315 7 by by IN cord-353298-vr5hnzp8 315 8 Uniformed Uniformed NNP cord-353298-vr5hnzp8 315 9 Services Services NNP cord-353298-vr5hnzp8 315 10 University University NNP cord-353298-vr5hnzp8 315 11 of of IN cord-353298-vr5hnzp8 315 12 Health Health NNP cord-353298-vr5hnzp8 315 13 Sciences Sciences NNPS cord-353298-vr5hnzp8 315 14 grant grant NN cord-353298-vr5hnzp8 315 15 R07403 r07403 NN cord-353298-vr5hnzp8 315 16 . . . cord-353298-vr5hnzp8 316 1 The the DT cord-353298-vr5hnzp8 316 2 opinions opinion NNS cord-353298-vr5hnzp8 316 3 expressed express VBN cord-353298-vr5hnzp8 316 4 are be VBP cord-353298-vr5hnzp8 316 5 the the DT cord-353298-vr5hnzp8 316 6 private private JJ cord-353298-vr5hnzp8 316 7 views view NNS cord-353298-vr5hnzp8 316 8 of of IN cord-353298-vr5hnzp8 316 9 the the DT cord-353298-vr5hnzp8 316 10 authors author NNS cord-353298-vr5hnzp8 316 11 and and CC cord-353298-vr5hnzp8 316 12 should should MD cord-353298-vr5hnzp8 316 13 not not RB cord-353298-vr5hnzp8 316 14 be be VB cord-353298-vr5hnzp8 316 15 construed construe VBN cord-353298-vr5hnzp8 316 16 as as IN cord-353298-vr5hnzp8 316 17 official official JJ cord-353298-vr5hnzp8 316 18 or or CC cord-353298-vr5hnzp8 316 19 necessarily necessarily RB cord-353298-vr5hnzp8 316 20 reflecting reflect VBG cord-353298-vr5hnzp8 316 21 the the DT cord-353298-vr5hnzp8 316 22 views view NNS cord-353298-vr5hnzp8 316 23 of of IN cord-353298-vr5hnzp8 316 24 the the DT cord-353298-vr5hnzp8 316 25 Uniformed Uniformed NNP cord-353298-vr5hnzp8 316 26 Services Services NNPS cord-353298-vr5hnzp8 316 27 School School NNP cord-353298-vr5hnzp8 316 28 of of IN cord-353298-vr5hnzp8 316 29 Medicine Medicine NNP cord-353298-vr5hnzp8 316 30 or or CC cord-353298-vr5hnzp8 316 31 the the DT cord-353298-vr5hnzp8 316 32 Department Department NNP cord-353298-vr5hnzp8 316 33 of of IN cord-353298-vr5hnzp8 316 34 Defense Defense NNP cord-353298-vr5hnzp8 316 35 . . . cord-353298-vr5hnzp8 317 1 Received receive VBN cord-353298-vr5hnzp8 317 2 for for IN cord-353298-vr5hnzp8 317 3 publication publication NN cord-353298-vr5hnzp8 317 4 15 15 CD cord-353298-vr5hnzp8 317 5 December December NNP cord-353298-vr5hnzp8 317 6 1989 1989 CD cord-353298-vr5hnzp8 317 7 and and CC cord-353298-vr5hnzp8 317 8 in in IN cord-353298-vr5hnzp8 317 9 revised revise VBN cord-353298-vr5hnzp8 317 10 form form NN cord-353298-vr5hnzp8 317 11 16 16 CD cord-353298-vr5hnzp8 317 12 April April NNP cord-353298-vr5hnzp8 317 13 1990 1990 CD cord-353298-vr5hnzp8 317 14 . . .