id	sid	tid	token	lemma	pos
cord-290566-tmsocyfc	1	1	key	key	JJ
cord-290566-tmsocyfc	1	2	:	:	:
cord-290566-tmsocyfc	1	3	cord-290566-tmsocyfc	cord-290566-tmsocyfc	VBN
cord-290566-tmsocyfc	1	4	authors	author	NNS
cord-290566-tmsocyfc	1	5	:	:	:
cord-290566-tmsocyfc	1	6	Chitnis	Chitnis	NNP
cord-290566-tmsocyfc	1	7	,	,	,
cord-290566-tmsocyfc	1	8	Tanuja	Tanuja	NNP
cord-290566-tmsocyfc	1	9	title	title	NN
cord-290566-tmsocyfc	1	10	:	:	:
cord-290566-tmsocyfc	1	11	The	the	DT
cord-290566-tmsocyfc	1	12	Role	role	NN
cord-290566-tmsocyfc	1	13	of	of	IN
cord-290566-tmsocyfc	1	14	CD4	CD4	NNP
cord-290566-tmsocyfc	1	15	T	T	NNP
cord-290566-tmsocyfc	1	16	Cells	Cells	NNPS
cord-290566-tmsocyfc	1	17	in	in	IN
cord-290566-tmsocyfc	1	18	the	the	DT
cord-290566-tmsocyfc	1	19	Pathogenesis	Pathogenesis	NNP
cord-290566-tmsocyfc	1	20	of	of	IN
cord-290566-tmsocyfc	1	21	Multiple	Multiple	NNP
cord-290566-tmsocyfc	1	22	Sclerosis	Sclerosis	NNP
cord-290566-tmsocyfc	1	23	date	date	NN
cord-290566-tmsocyfc	1	24	:	:	:
cord-290566-tmsocyfc	1	25	2007	2007	CD
cord-290566-tmsocyfc	1	26	-	-	SYM
cord-290566-tmsocyfc	1	27	05	05	CD
cord-290566-tmsocyfc	1	28	-	-	HYPH
cord-290566-tmsocyfc	1	29	25	25	CD
cord-290566-tmsocyfc	1	30	journal	journal	NN
cord-290566-tmsocyfc	1	31	:	:	:
cord-290566-tmsocyfc	1	32	Int	Int	NNP
cord-290566-tmsocyfc	1	33	Rev	Rev	NNP
cord-290566-tmsocyfc	1	34	Neurobiol	Neurobiol	NNP
cord-290566-tmsocyfc	1	35	DOI	DOI	NNP
cord-290566-tmsocyfc	1	36	:	:	:
cord-290566-tmsocyfc	1	37	10.1016	10.1016	CD
cord-290566-tmsocyfc	1	38	/	/	SYM
cord-290566-tmsocyfc	1	39	s0074	s0074	NNP
cord-290566-tmsocyfc	1	40	-	-	HYPH
cord-290566-tmsocyfc	1	41	7742(07)79003	7742(07)79003	NNP
cord-290566-tmsocyfc	1	42	-	-	HYPH
cord-290566-tmsocyfc	1	43	7	7	CD
cord-290566-tmsocyfc	1	44	sha	sha	NNP
cord-290566-tmsocyfc	1	45	:	:	:
cord-290566-tmsocyfc	1	46	c7f8760df509ef0c7f11a4c1bc9851f15b07fd78	c7f8760df509ef0c7f11a4c1bc9851f15b07fd78	CD
cord-290566-tmsocyfc	1	47	doc_id	doc_id	CD
cord-290566-tmsocyfc	1	48	:	:	:
cord-290566-tmsocyfc	1	49	290566	290566	CD
cord-290566-tmsocyfc	1	50	cord_uid	cord_uid	NNS
cord-290566-tmsocyfc	1	51	:	:	:
cord-290566-tmsocyfc	1	52	tmsocyfc	tmsocyfc	VBN
cord-290566-tmsocyfc	1	53	T	T	NNP
cord-290566-tmsocyfc	1	54	lymphocytes	lymphocyte	NNS
cord-290566-tmsocyfc	1	55	play	play	VBP
cord-290566-tmsocyfc	1	56	a	a	DT
cord-290566-tmsocyfc	1	57	central	central	JJ
cord-290566-tmsocyfc	1	58	role	role	NN
cord-290566-tmsocyfc	1	59	in	in	IN
cord-290566-tmsocyfc	1	60	the	the	DT
cord-290566-tmsocyfc	1	61	pathogenesis	pathogenesis	NN
cord-290566-tmsocyfc	1	62	of	of	IN
cord-290566-tmsocyfc	1	63	multiple	multiple	JJ
cord-290566-tmsocyfc	1	64	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	1	65	(	(	-LRB-
cord-290566-tmsocyfc	1	66	MS	MS	NNP
cord-290566-tmsocyfc	1	67	)	)	-RRB-
cord-290566-tmsocyfc	2	1	(	(	-LRB-
cord-290566-tmsocyfc	2	2	Zhang	Zhang	NNP
cord-290566-tmsocyfc	2	3	et	et	NNP
cord-290566-tmsocyfc	2	4	al	al	NNP
cord-290566-tmsocyfc	2	5	.	.	NNP
cord-290566-tmsocyfc	2	6	,	,	,
cord-290566-tmsocyfc	2	7	1992	1992	CD
cord-290566-tmsocyfc	2	8	)	)	-RRB-
cord-290566-tmsocyfc	2	9	.	.	.
cord-290566-tmsocyfc	3	1	Both	both	DT
cord-290566-tmsocyfc	3	2	CD4	CD4	NNP
cord-290566-tmsocyfc	3	3	+	+	CC
cord-290566-tmsocyfc	3	4	and	and	CC
cord-290566-tmsocyfc	3	5	CD8	CD8	NNP
cord-290566-tmsocyfc	3	6	+	+	CC
cord-290566-tmsocyfc	3	7	T	T	NNP
cord-290566-tmsocyfc	3	8	cells	cell	NNS
cord-290566-tmsocyfc	3	9	have	have	VBP
cord-290566-tmsocyfc	3	10	been	be	VBN
cord-290566-tmsocyfc	3	11	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	3	12	in	in	IN
cord-290566-tmsocyfc	3	13	MS	MS	NNP
cord-290566-tmsocyfc	3	14	lesions	lesion	NNS
cord-290566-tmsocyfc	3	15	,	,	,
cord-290566-tmsocyfc	3	16	with	with	IN
cord-290566-tmsocyfc	3	17	CD4	CD4	NNP
cord-290566-tmsocyfc	3	18	+	+	CC
cord-290566-tmsocyfc	3	19	T	t	NN
cord-290566-tmsocyfc	3	20	cells	cell	NNS
cord-290566-tmsocyfc	3	21	predominating	predominate	VBG
cord-290566-tmsocyfc	3	22	in	in	IN
cord-290566-tmsocyfc	3	23	acute	acute	JJ
cord-290566-tmsocyfc	3	24	lesions	lesion	NNS
cord-290566-tmsocyfc	3	25	and	and	CC
cord-290566-tmsocyfc	3	26	CD8	CD8	NNP
cord-290566-tmsocyfc	3	27	+	+	CC
cord-290566-tmsocyfc	3	28	T	T	NNP
cord-290566-tmsocyfc	3	29	cells	cell	NNS
cord-290566-tmsocyfc	3	30	being	be	VBG
cord-290566-tmsocyfc	3	31	observed	observe	VBN
cord-290566-tmsocyfc	3	32	more	more	RBR
cord-290566-tmsocyfc	3	33	frequently	frequently	RB
cord-290566-tmsocyfc	3	34	in	in	IN
cord-290566-tmsocyfc	3	35	chronic	chronic	JJ
cord-290566-tmsocyfc	3	36	lesions	lesion	NNS
cord-290566-tmsocyfc	3	37	(	(	-LRB-
cord-290566-tmsocyfc	3	38	Raine	Raine	NNP
cord-290566-tmsocyfc	3	39	,	,	,
cord-290566-tmsocyfc	3	40	1994	1994	CD
cord-290566-tmsocyfc	3	41	)	)	-RRB-
cord-290566-tmsocyfc	3	42	.	.	.
cord-290566-tmsocyfc	4	1	Additionally	additionally	RB
cord-290566-tmsocyfc	4	2	,	,	,
cord-290566-tmsocyfc	4	3	T	t	NN
cord-290566-tmsocyfc	4	4	cells	cell	NNS
cord-290566-tmsocyfc	4	5	are	be	VBP
cord-290566-tmsocyfc	4	6	found	find	VBN
cord-290566-tmsocyfc	4	7	in	in	IN
cord-290566-tmsocyfc	4	8	all	all	DT
cord-290566-tmsocyfc	4	9	four	four	CD
cord-290566-tmsocyfc	4	10	of	of	IN
cord-290566-tmsocyfc	4	11	the	the	DT
cord-290566-tmsocyfc	4	12	described	describe	VBN
cord-290566-tmsocyfc	4	13	histopathologic	histopathologic	JJ
cord-290566-tmsocyfc	4	14	subtypes	subtype	NNS
cord-290566-tmsocyfc	4	15	of	of	IN
cord-290566-tmsocyfc	4	16	MS	MS	NNP
cord-290566-tmsocyfc	4	17	(	(	-LRB-
cord-290566-tmsocyfc	4	18	Lucchinetti	Lucchinetti	NNP
cord-290566-tmsocyfc	4	19	et	et	NNP
cord-290566-tmsocyfc	4	20	al	al	NNP
cord-290566-tmsocyfc	4	21	.	.	NNP
cord-290566-tmsocyfc	4	22	,	,	,
cord-290566-tmsocyfc	4	23	2000	2000	CD
cord-290566-tmsocyfc	4	24	)	)	-RRB-
cord-290566-tmsocyfc	4	25	.	.	.
cord-290566-tmsocyfc	5	1	Activated	activate	VBN
cord-290566-tmsocyfc	5	2	myelin‐reactive	myelin‐reactive	NNP
cord-290566-tmsocyfc	5	3	CD4	CD4	NNP
cord-290566-tmsocyfc	5	4	+	+	CC
cord-290566-tmsocyfc	5	5	T	t	NN
cord-290566-tmsocyfc	5	6	cells	cell	NNS
cord-290566-tmsocyfc	5	7	are	be	VBP
cord-290566-tmsocyfc	5	8	present	present	JJ
cord-290566-tmsocyfc	5	9	in	in	IN
cord-290566-tmsocyfc	5	10	the	the	DT
cord-290566-tmsocyfc	5	11	blood	blood	NN
cord-290566-tmsocyfc	5	12	and	and	CC
cord-290566-tmsocyfc	5	13	cerebrospinal	cerebrospinal	NN
cord-290566-tmsocyfc	5	14	fluid	fluid	NN
cord-290566-tmsocyfc	5	15	(	(	-LRB-
cord-290566-tmsocyfc	5	16	CSF	CSF	NNP
cord-290566-tmsocyfc	5	17	)	)	-RRB-
cord-290566-tmsocyfc	5	18	of	of	IN
cord-290566-tmsocyfc	5	19	MS	MS	NNP
cord-290566-tmsocyfc	5	20	patients	patient	NNS
cord-290566-tmsocyfc	5	21	;	;	:
cord-290566-tmsocyfc	5	22	in	in	IN
cord-290566-tmsocyfc	5	23	contrast	contrast	NN
cord-290566-tmsocyfc	5	24	,	,	,
cord-290566-tmsocyfc	5	25	only	only	RB
cord-290566-tmsocyfc	5	26	nonactivated	nonactivate	VBD
cord-290566-tmsocyfc	5	27	myelin‐reactive	myelin‐reactive	NNP
cord-290566-tmsocyfc	5	28	T	T	NNP
cord-290566-tmsocyfc	5	29	cells	cell	NNS
cord-290566-tmsocyfc	5	30	are	be	VBP
cord-290566-tmsocyfc	5	31	present	present	JJ
cord-290566-tmsocyfc	5	32	in	in	IN
cord-290566-tmsocyfc	5	33	the	the	DT
cord-290566-tmsocyfc	5	34	blood	blood	NN
cord-290566-tmsocyfc	5	35	of	of	IN
cord-290566-tmsocyfc	5	36	controls	control	NNS
cord-290566-tmsocyfc	6	1	(	(	-LRB-
cord-290566-tmsocyfc	6	2	Zhang	Zhang	NNP
cord-290566-tmsocyfc	6	3	et	et	NNP
cord-290566-tmsocyfc	6	4	al	al	NNP
cord-290566-tmsocyfc	6	5	.	.	NNP
cord-290566-tmsocyfc	6	6	,	,	,
cord-290566-tmsocyfc	6	7	1994	1994	CD
cord-290566-tmsocyfc	6	8	)	)	-RRB-
cord-290566-tmsocyfc	6	9	.	.	.
cord-290566-tmsocyfc	7	1	The	the	DT
cord-290566-tmsocyfc	7	2	success	success	NN
cord-290566-tmsocyfc	7	3	of	of	IN
cord-290566-tmsocyfc	7	4	several	several	JJ
cord-290566-tmsocyfc	7	5	T‐cell‐targeted	t‐cell‐targeted	JJ
cord-290566-tmsocyfc	7	6	therapies	therapy	NNS
cord-290566-tmsocyfc	7	7	in	in	IN
cord-290566-tmsocyfc	7	8	MS	MS	NNP
cord-290566-tmsocyfc	7	9	reinforces	reinforce	VBZ
cord-290566-tmsocyfc	7	10	the	the	DT
cord-290566-tmsocyfc	7	11	importance	importance	NN
cord-290566-tmsocyfc	7	12	of	of	IN
cord-290566-tmsocyfc	7	13	the	the	DT
cord-290566-tmsocyfc	7	14	role	role	NN
cord-290566-tmsocyfc	7	15	of	of	IN
cord-290566-tmsocyfc	7	16	the	the	DT
cord-290566-tmsocyfc	7	17	T	T	NNP
cord-290566-tmsocyfc	7	18	cell	cell	NN
cord-290566-tmsocyfc	7	19	in	in	IN
cord-290566-tmsocyfc	7	20	MS	MS	NNP
cord-290566-tmsocyfc	7	21	pathogenesis	pathogenesis	NN
cord-290566-tmsocyfc	7	22	.	.	.
cord-290566-tmsocyfc	8	1	Here	here	RB
cord-290566-tmsocyfc	8	2	,	,	,
cord-290566-tmsocyfc	8	3	we	-PRON-	PRP
cord-290566-tmsocyfc	8	4	outline	outline	VBP
cord-290566-tmsocyfc	8	5	basic	basic	JJ
cord-290566-tmsocyfc	8	6	concepts	concept	NNS
cord-290566-tmsocyfc	8	7	in	in	IN
cord-290566-tmsocyfc	8	8	CD4	CD4	NNP
cord-290566-tmsocyfc	8	9	+	+	CC
cord-290566-tmsocyfc	8	10	T‐cell	T‐cell	NNP
cord-290566-tmsocyfc	8	11	immunology	immunology	NN
cord-290566-tmsocyfc	8	12	and	and	CC
cord-290566-tmsocyfc	8	13	summarize	summarize	VB
cord-290566-tmsocyfc	8	14	the	the	DT
cord-290566-tmsocyfc	8	15	current	current	JJ
cord-290566-tmsocyfc	8	16	understanding	understanding	NN
cord-290566-tmsocyfc	8	17	of	of	IN
cord-290566-tmsocyfc	8	18	the	the	DT
cord-290566-tmsocyfc	8	19	role	role	NN
cord-290566-tmsocyfc	8	20	of	of	IN
cord-290566-tmsocyfc	8	21	CD4	CD4	NNP
cord-290566-tmsocyfc	8	22	+	+	CC
cord-290566-tmsocyfc	8	23	T	T	NNP
cord-290566-tmsocyfc	8	24	cells	cell	NNS
cord-290566-tmsocyfc	8	25	in	in	IN
cord-290566-tmsocyfc	8	26	the	the	DT
cord-290566-tmsocyfc	8	27	pathogenesis	pathogenesis	NN
cord-290566-tmsocyfc	8	28	of	of	IN
cord-290566-tmsocyfc	8	29	MS	MS	NNP
cord-290566-tmsocyfc	8	30	.	.	.
cord-290566-tmsocyfc	9	1	T	T	NNP
cord-290566-tmsocyfc	9	2	lymphocytes	lymphocyte	NNS
cord-290566-tmsocyfc	9	3	play	play	VBP
cord-290566-tmsocyfc	9	4	a	a	DT
cord-290566-tmsocyfc	9	5	central	central	JJ
cord-290566-tmsocyfc	9	6	role	role	NN
cord-290566-tmsocyfc	9	7	in	in	IN
cord-290566-tmsocyfc	9	8	the	the	DT
cord-290566-tmsocyfc	9	9	pathogenesis	pathogenesis	NN
cord-290566-tmsocyfc	9	10	of	of	IN
cord-290566-tmsocyfc	9	11	multiple	multiple	JJ
cord-290566-tmsocyfc	9	12	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	9	13	(	(	-LRB-
cord-290566-tmsocyfc	9	14	MS	MS	NNP
cord-290566-tmsocyfc	9	15	)	)	-RRB-
cord-290566-tmsocyfc	10	1	(	(	-LRB-
cord-290566-tmsocyfc	10	2	Zhan	Zhan	NNP
cord-290566-tmsocyfc	10	3	g	g	NNP
cord-290566-tmsocyfc	10	4	et	et	FW
cord-290566-tmsocyfc	10	5	al	al	NNP
cord-290566-tmsocyfc	10	6	.	.	NNP
cord-290566-tmsocyfc	10	7	,	,	,
cord-290566-tmsocyfc	10	8	1992	1992	CD
cord-290566-tmsocyfc	10	9	)	)	-RRB-
cord-290566-tmsocyfc	10	10	.	.	.
cord-290566-tmsocyfc	11	1	Both	both	DT
cord-290566-tmsocyfc	11	2	CD4	CD4	NNP
cord-290566-tmsocyfc	11	3	þ	þ	NNP
cord-290566-tmsocyfc	11	4	and	and	CC
cord-290566-tmsocyfc	11	5	CD8	CD8	NNP
cord-290566-tmsocyfc	11	6	þ	þ	NNP
cord-290566-tmsocyfc	11	7	T	T	NNP
cord-290566-tmsocyfc	11	8	cells	cell	NNS
cord-290566-tmsocyfc	11	9	have	have	VBP
cord-290566-tmsocyfc	11	10	been	be	VBN
cord-290566-tmsocyfc	11	11	demon	demon	NN
cord-290566-tmsocyfc	11	12	strated	strate	VBN
cord-290566-tmsocyfc	11	13	in	in	IN
cord-290566-tmsocyfc	11	14	MS	MS	NNP
cord-290566-tmsocyfc	11	15	lesions	lesion	NNS
cord-290566-tmsocyfc	11	16	,	,	,
cord-290566-tmsocyfc	11	17	with	with	IN
cord-290566-tmsocyfc	11	18	CD4	CD4	NNP
cord-290566-tmsocyfc	11	19	þ	þ	NNP
cord-290566-tmsocyfc	11	20	T	T	NNP
cord-290566-tmsocyfc	11	21	cells	cell	NNS
cord-290566-tmsocyfc	11	22	predom	predom	NNP
cord-290566-tmsocyfc	11	23	inating	inate	VBG
cord-290566-tmsocyfc	11	24	in	in	IN
cord-290566-tmsocyfc	11	25	acu	acu	NNP
cord-290566-tmsocyfc	11	26	te	te	NNP
cord-290566-tmsocyfc	11	27	lesions	lesion	NNS
cord-290566-tmsocyfc	11	28	and	and	CC
cord-290566-tmsocyfc	11	29	CD	CD	NNP
cord-290566-tmsocyfc	11	30	8þ	8þ	NNS
cord-290566-tmsocyfc	11	31	T	t	NN
cord-290566-tmsocyfc	11	32	cells	cell	NNS
cord-290566-tmsocyfc	11	33	being	be	VBG
cord-290566-tmsocyfc	11	34	obser	obser	NNP
cord-290566-tmsocyfc	11	35	ved	ved	NNP
cord-290566-tmsocyfc	11	36	more	more	JJR
cord-290566-tmsocyfc	11	37	frequen	frequen	NNP
cord-290566-tmsocyfc	11	38	tly	tly	RB
cord-290566-tmsocyfc	11	39	in	in	IN
cord-290566-tmsocyfc	11	40	chronic	chronic	JJ
cord-290566-tmsocyfc	11	41	lesions	lesion	NNS
cord-290566-tmsocyfc	11	42	(	(	-LRB-
cord-290566-tmsocyfc	11	43	Raine	Raine	NNP
cord-290566-tmsocyfc	11	44	,	,	,
cord-290566-tmsocyfc	11	45	1994	1994	CD
cord-290566-tmsocyfc	11	46	)	)	-RRB-
cord-290566-tmsocyfc	11	47	.	.	.
cord-290566-tmsocyfc	12	1	Additiona	Additiona	NNP
cord-290566-tmsocyfc	12	2	lly	lly	RB
cord-290566-tmsocyfc	12	3	,	,	,
cord-290566-tmsocyfc	12	4	T	t	NN
cord-290566-tmsocyfc	12	5	cells	cell	NNS
cord-290566-tmsocyfc	12	6	are	be	VBP
cord-290566-tmsocyfc	12	7	found	find	VBN
cord-290566-tmsocyfc	12	8	in	in	IN
cord-290566-tmsocyfc	12	9	all	all	DT
cord-290566-tmsocyfc	12	10	four	four	CD
cord-290566-tmsocyfc	12	11	of	of	IN
cord-290566-tmsocyfc	12	12	the	the	DT
cord-290566-tmsocyfc	12	13	described	describe	VBN
cord-290566-tmsocyfc	12	14	histopathologic	histopathologic	JJ
cord-290566-tmsocyfc	12	15	subtypes	subtype	NNS
cord-290566-tmsocyfc	12	16	of	of	IN
cord-290566-tmsocyfc	12	17	MS	MS	NNP
cord-290566-tmsocyfc	12	18	(	(	-LRB-
cord-290566-tmsocyfc	12	19	Lucchinetti	Lucchinetti	NNP
cord-290566-tmsocyfc	12	20	et	et	NNP
cord-290566-tmsocyfc	12	21	al	al	NNP
cord-290566-tmsocyfc	12	22	.	.	NNP
cord-290566-tmsocyfc	12	23	,	,	,
cord-290566-tmsocyfc	12	24	2000	2000	CD
cord-290566-tmsocyfc	12	25	)	)	-RRB-
cord-290566-tmsocyfc	12	26	.	.	.
cord-290566-tmsocyfc	13	1	Activated	activate	VBN
cord-290566-tmsocyfc	13	2	myelin	myelin	NN
cord-290566-tmsocyfc	13	3	-	-	HYPH
cord-290566-tmsocyfc	13	4	reactive	reactive	JJ
cord-290566-tmsocyfc	13	5	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	13	6	T	T	NNP
cord-290566-tmsocyfc	13	7	cells	cell	NNS
cord-290566-tmsocyfc	13	8	are	be	VBP
cord-290566-tmsocyfc	13	9	present	present	JJ
cord-290566-tmsocyfc	13	10	in	in	IN
cord-290566-tmsocyfc	13	11	the	the	DT
cord-290566-tmsocyfc	13	12	blood	blood	NN
cord-290566-tmsocyfc	13	13	and	and	CC
cord-290566-tmsocyfc	13	14	cerebrospinal	cerebrospinal	NN
cord-290566-tmsocyfc	13	15	fluid	fluid	NN
cord-290566-tmsocyfc	13	16	(	(	-LRB-
cord-290566-tmsocyfc	13	17	CSF	CSF	NNP
cord-290566-tmsocyfc	13	18	)	)	-RRB-
cord-290566-tmsocyfc	13	19	of	of	IN
cord-290566-tmsocyfc	13	20	MS	MS	NNP
cord-290566-tmsocyfc	13	21	patients	patient	NNS
cord-290566-tmsocyfc	13	22	;	;	:
cord-290566-tmsocyfc	13	23	in	in	IN
cord-290566-tmsocyfc	13	24	contrast	contrast	NN
cord-290566-tmsocyfc	13	25	,	,	,
cord-290566-tmsocyfc	13	26	only	only	RB
cord-290566-tmsocyfc	13	27	nonactivated	nonactivate	VBD
cord-290566-tmsocyfc	13	28	myelinreactive	myelinreactive	NNP
cord-290566-tmsocyfc	13	29	T	T	NNP
cord-290566-tmsocyfc	13	30	cells	cell	NNS
cord-290566-tmsocyfc	13	31	are	be	VBP
cord-290566-tmsocyfc	13	32	prese	prese	NNPS
cord-290566-tmsocyfc	13	33	nt	nt	RB
cord-290566-tmsocyfc	13	34	in	in	IN
cord-290566-tmsocyfc	13	35	the	the	DT
cord-290566-tmsocyfc	13	36	blood	blood	NN
cord-290566-tmsocyfc	13	37	of	of	IN
cord-290566-tmsocyfc	13	38	controls	control	NNS
cord-290566-tmsocyfc	14	1	(	(	-LRB-
cord-290566-tmsocyfc	14	2	Zhan	Zhan	NNP
cord-290566-tmsocyfc	14	3	g	g	NNP
cord-290566-tmsocyfc	14	4	et	et	FW
cord-290566-tmsocyfc	14	5	al	al	NNP
cord-290566-tmsocyfc	14	6	.	.	NNP
cord-290566-tmsocyfc	14	7	,	,	,
cord-290566-tmsocyfc	14	8	1994	1994	CD
cord-290566-tmsocyfc	14	9	)	)	-RRB-
cord-290566-tmsocyfc	14	10	.	.	.
cord-290566-tmsocyfc	15	1	The	the	DT
cord-290566-tmsocyfc	15	2	succes	succe	NNS
cord-290566-tmsocyfc	15	3	s	s	NNP
cord-290566-tmsocyfc	15	4	of	of	IN
cord-290566-tmsocyfc	15	5	several	several	JJ
cord-290566-tmsocyfc	15	6	T	t	NN
cord-290566-tmsocyfc	15	7	-	-	HYPH
cord-290566-tmsocyfc	15	8	cell	cell	NN
cord-290566-tmsocyfc	15	9	-	-	HYPH
cord-290566-tmsocyfc	15	10	targeted	target	VBN
cord-290566-tmsocyfc	15	11	therapies	therapy	NNS
cord-290566-tmsocyfc	15	12	in	in	IN
cord-290566-tmsocyfc	15	13	MS	MS	NNP
cord-290566-tmsocyfc	15	14	reinforces	reinforce	VBZ
cord-290566-tmsocyfc	15	15	the	the	DT
cord-290566-tmsocyfc	15	16	importance	importance	NN
cord-290566-tmsocyfc	15	17	of	of	IN
cord-290566-tmsocyfc	15	18	the	the	DT
cord-290566-tmsocyfc	15	19	role	role	NN
cord-290566-tmsocyfc	15	20	by	by	IN
cord-290566-tmsocyfc	15	21	the	the	DT
cord-290566-tmsocyfc	15	22	CD3	CD3	NNP
cord-290566-tmsocyfc	15	23	antigen	antigen	NNP
cord-290566-tmsocyfc	15	24	.	.	.
cord-290566-tmsocyfc	16	1	The	the	DT
cord-290566-tmsocyfc	16	2	cytoplasmic	cytoplasmic	JJ
cord-290566-tmsocyfc	16	3	tail	tail	NN
cord-290566-tmsocyfc	16	4	of	of	IN
cord-290566-tmsocyfc	16	5	the	the	DT
cord-290566-tmsocyfc	16	6	CD3	CD3	NNP
cord-290566-tmsocyfc	16	7	proteins	protein	NNS
cord-290566-tmsocyfc	16	8	contains	contain	VBZ
cord-290566-tmsocyfc	16	9	one	one	CD
cord-290566-tmsocyfc	16	10	copy	copy	NN
cord-290566-tmsocyfc	16	11	of	of	IN
cord-290566-tmsocyfc	16	12	a	a	DT
cord-290566-tmsocyfc	16	13	sequence	sequence	NN
cord-290566-tmsocyfc	16	14	motif	motif	NN
cord-290566-tmsocyfc	16	15	important	important	JJ
cord-290566-tmsocyfc	16	16	for	for	IN
cord-290566-tmsocyfc	16	17	signaling	signal	VBG
cord-290566-tmsocyfc	16	18	functions	function	NNS
cord-290566-tmsocyfc	16	19	,	,	,
cord-290566-tmsocyfc	16	20	called	call	VBD
cord-290566-tmsocyfc	16	21	the	the	DT
cord-290566-tmsocyfc	16	22	immunoreceptor	immunoreceptor	NNP
cord-290566-tmsocyfc	16	23	tyrosine	tyrosine	NN
cord-290566-tmsocyfc	16	24	-	-	HYPH
cord-290566-tmsocyfc	16	25	based	base	VBN
cord-290566-tmsocyfc	16	26	activation	activation	NN
cord-290566-tmsocyfc	16	27	motif	motif	NN
cord-290566-tmsocyfc	16	28	(	(	-LRB-
cord-290566-tmsocyfc	16	29	ITAM	ITAM	NNP
cord-290566-tmsocyfc	16	30	)	)	-RRB-
cord-290566-tmsocyfc	16	31	.	.	.
cord-290566-tmsocyfc	17	1	Phosphorylation	Phosphorylation	NNP
cord-290566-tmsocyfc	17	2	of	of	IN
cord-290566-tmsocyfc	17	3	the	the	DT
cord-290566-tmsocyfc	17	4	ITAM	ITAM	NNP
cord-290566-tmsocyfc	17	5	initiates	initiate	VBZ
cord-290566-tmsocyfc	17	6	intracellular	intracellular	JJ
cord-290566-tmsocyfc	17	7	signaling	signal	VBG
cord-290566-tmsocyfc	17	8	events	event	NNS
cord-290566-tmsocyfc	17	9	.	.	.
cord-290566-tmsocyfc	18	1	The	the	DT
cord-290566-tmsocyfc	18	2	interaction	interaction	NN
cord-290566-tmsocyfc	18	3	of	of	IN
cord-290566-tmsocyfc	18	4	MHC	MHC	NNP
cord-290566-tmsocyfc	18	5	-	-	HYPH
cord-290566-tmsocyfc	18	6	peptide	peptide	NN
cord-290566-tmsocyfc	18	7	complex	complex	NN
cord-290566-tmsocyfc	18	8	with	with	IN
cord-290566-tmsocyfc	18	9	T	t	NN
cord-290566-tmsocyfc	18	10	cells	cell	NNS
cord-290566-tmsocyfc	18	11	,	,	,
cord-290566-tmsocyfc	18	12	while	while	IN
cord-290566-tmsocyfc	18	13	necessary	necessary	JJ
cord-290566-tmsocyfc	18	14	,	,	,
cord-290566-tmsocyfc	18	15	is	be	VBZ
cord-290566-tmsocyfc	18	16	insuYcient	insuycient	JJ
cord-290566-tmsocyfc	18	17	for	for	IN
cord-290566-tmsocyfc	18	18	T	t	NN
cord-290566-tmsocyfc	18	19	-	-	HYPH
cord-290566-tmsocyfc	18	20	cell	cell	NN
cord-290566-tmsocyfc	18	21	activation	activation	NN
cord-290566-tmsocyfc	18	22	.	.	.
cord-290566-tmsocyfc	19	1	Additional	additional	JJ
cord-290566-tmsocyfc	19	2	classes	class	NNS
cord-290566-tmsocyfc	19	3	of	of	IN
cord-290566-tmsocyfc	19	4	molecules	molecule	NNS
cord-290566-tmsocyfc	19	5	are	be	VBP
cord-290566-tmsocyfc	19	6	involved	involve	VBN
cord-290566-tmsocyfc	19	7	in	in	IN
cord-290566-tmsocyfc	19	8	T	t	NN
cord-290566-tmsocyfc	19	9	-	-	HYPH
cord-290566-tmsocyfc	19	10	cell	cell	NN
cord-290566-tmsocyfc	19	11	antigen	antigen	NN
cord-290566-tmsocyfc	19	12	recognition	recognition	NN
cord-290566-tmsocyfc	19	13	,	,	,
cord-290566-tmsocyfc	19	14	activation	activation	NN
cord-290566-tmsocyfc	19	15	,	,	,
cord-290566-tmsocyfc	19	16	intracellular	intracellular	JJ
cord-290566-tmsocyfc	19	17	signaling	signaling	NN
cord-290566-tmsocyfc	19	18	,	,	,
cord-290566-tmsocyfc	19	19	adhesion	adhesion	NN
cord-290566-tmsocyfc	19	20	,	,	,
cord-290566-tmsocyfc	19	21	and	and	CC
cord-290566-tmsocyfc	19	22	traYcking	traycking	NN
cord-290566-tmsocyfc	19	23	of	of	IN
cord-290566-tmsocyfc	19	24	T	T	NNP
cord-290566-tmsocyfc	19	25	cells	cell	NNS
cord-290566-tmsocyfc	19	26	to	to	IN
cord-290566-tmsocyfc	19	27	their	-PRON-	PRP$
cord-290566-tmsocyfc	19	28	target	target	NN
cord-290566-tmsocyfc	19	29	organs	organ	NNS
cord-290566-tmsocyfc	19	30	.	.	.
cord-290566-tmsocyfc	20	1	Two	two	CD
cord-290566-tmsocyfc	20	2	signals	signal	NNS
cord-290566-tmsocyfc	20	3	are	be	VBP
cord-290566-tmsocyfc	20	4	required	require	VBN
cord-290566-tmsocyfc	20	5	for	for	IN
cord-290566-tmsocyfc	20	6	T	T	NNP
cord-290566-tmsocyfc	20	7	lymphocyte	lymphocyte	NN
cord-290566-tmsocyfc	20	8	activation	activation	NN
cord-290566-tmsocyfc	20	9	.	.	.
cord-290566-tmsocyfc	21	1	According	accord	VBG
cord-290566-tmsocyfc	21	2	to	to	IN
cord-290566-tmsocyfc	21	3	this	this	DT
cord-290566-tmsocyfc	21	4	'	'	''
cord-290566-tmsocyfc	21	5	'	'	''
cord-290566-tmsocyfc	21	6	two	two	CD
cord-290566-tmsocyfc	21	7	-	-	HYPH
cord-290566-tmsocyfc	21	8	signal	signal	NN
cord-290566-tmsocyfc	21	9	'	'	''
cord-290566-tmsocyfc	21	10	'	'	''
cord-290566-tmsocyfc	21	11	model	model	NN
cord-290566-tmsocyfc	21	12	(	(	-LRB-
cord-290566-tmsocyfc	21	13	Bretscher	Bretscher	NNP
cord-290566-tmsocyfc	21	14	and	and	CC
cord-290566-tmsocyfc	21	15	Cohn	Cohn	NNP
cord-290566-tmsocyfc	21	16	,	,	,
cord-290566-tmsocyfc	21	17	1970	1970	CD
cord-290566-tmsocyfc	21	18	)	)	-RRB-
cord-290566-tmsocyfc	21	19	,	,	,
cord-290566-tmsocyfc	21	20	'	'	''
cord-290566-tmsocyfc	21	21	'	'	``
cord-290566-tmsocyfc	21	22	signal	signal	NN
cord-290566-tmsocyfc	21	23	1	1	CD
cord-290566-tmsocyfc	21	24	'	'	''
cord-290566-tmsocyfc	21	25	'	'	''
cord-290566-tmsocyfc	21	26	consists	consist	NNS
cord-290566-tmsocyfc	21	27	of	of	IN
cord-290566-tmsocyfc	21	28	the	the	DT
cord-290566-tmsocyfc	21	29	interaction	interaction	NN
cord-290566-tmsocyfc	21	30	of	of	IN
cord-290566-tmsocyfc	21	31	the	the	DT
cord-290566-tmsocyfc	21	32	TCR	TCR	NNP
cord-290566-tmsocyfc	21	33	with	with	IN
cord-290566-tmsocyfc	21	34	antigen	antigen	NN
cord-290566-tmsocyfc	21	35	,	,	,
cord-290566-tmsocyfc	21	36	presented	present	VBN
cord-290566-tmsocyfc	21	37	by	by	IN
cord-290566-tmsocyfc	21	38	the	the	DT
cord-290566-tmsocyfc	21	39	MHC	MHC	NNP
cord-290566-tmsocyfc	21	40	on	on	IN
cord-290566-tmsocyfc	21	41	the	the	DT
cord-290566-tmsocyfc	21	42	surface	surface	NN
cord-290566-tmsocyfc	21	43	of	of	IN
cord-290566-tmsocyfc	21	44	APCs	apc	NNS
cord-290566-tmsocyfc	21	45	.	.	.
cord-290566-tmsocyfc	21	46	''	''	''
cord-290566-tmsocyfc	22	1	Signal	signal	NN
cord-290566-tmsocyfc	22	2	2	2	CD
cord-290566-tmsocyfc	22	3	'	'	''
cord-290566-tmsocyfc	22	4	'	'	''
cord-290566-tmsocyfc	22	5	consists	consist	NNS
cord-290566-tmsocyfc	22	6	of	of	IN
cord-290566-tmsocyfc	22	7	the	the	DT
cord-290566-tmsocyfc	22	8	engagement	engagement	NN
cord-290566-tmsocyfc	22	9	of	of	IN
cord-290566-tmsocyfc	22	10	costimulatory	costimulatory	NNP
cord-290566-tmsocyfc	22	11	receptors	receptor	NNS
cord-290566-tmsocyfc	22	12	on	on	IN
cord-290566-tmsocyfc	22	13	the	the	DT
cord-290566-tmsocyfc	22	14	Tcell	Tcell	NNP
cord-290566-tmsocyfc	22	15	by	by	IN
cord-290566-tmsocyfc	22	16	ligands	ligand	NNS
cord-290566-tmsocyfc	22	17	present	present	JJ
cord-290566-tmsocyfc	22	18	on	on	IN
cord-290566-tmsocyfc	22	19	the	the	DT
cord-290566-tmsocyfc	22	20	surface	surface	NN
cord-290566-tmsocyfc	22	21	of	of	IN
cord-290566-tmsocyfc	22	22	APCs	apc	NNS
cord-290566-tmsocyfc	22	23	(	(	-LRB-
cord-290566-tmsocyfc	22	24	Alegre	Alegre	NNP
cord-290566-tmsocyfc	22	25	et	et	NNP
cord-290566-tmsocyfc	22	26	al	al	NNP
cord-290566-tmsocyfc	22	27	.	.	NNP
cord-290566-tmsocyfc	22	28	,	,	,
cord-290566-tmsocyfc	22	29	2001	2001	CD
cord-290566-tmsocyfc	22	30	;	;	:
cord-290566-tmsocyfc	22	31	Bretscher	Bretscher	NNP
cord-290566-tmsocyfc	22	32	,	,	,
cord-290566-tmsocyfc	22	33	1999	1999	CD
cord-290566-tmsocyfc	22	34	)	)	-RRB-
cord-290566-tmsocyfc	22	35	.	.	.
cord-290566-tmsocyfc	23	1	After	after	IN
cord-290566-tmsocyfc	23	2	contact	contact	NN
cord-290566-tmsocyfc	23	3	with	with	IN
cord-290566-tmsocyfc	23	4	specific	specific	JJ
cord-290566-tmsocyfc	23	5	antigen	antigen	NN
cord-290566-tmsocyfc	23	6	-	-	HYPH
cord-290566-tmsocyfc	23	7	MHC	MHC	NNP
cord-290566-tmsocyfc	23	8	complex	complex	NN
cord-290566-tmsocyfc	23	9	and	and	CC
cord-290566-tmsocyfc	23	10	adequate	adequate	JJ
cord-290566-tmsocyfc	23	11	costimulatory	costimulatory	NN
cord-290566-tmsocyfc	23	12	signals	signal	NNS
cord-290566-tmsocyfc	23	13	,	,	,
cord-290566-tmsocyfc	23	14	T	t	NN
cord-290566-tmsocyfc	23	15	cells	cell	NNS
cord-290566-tmsocyfc	23	16	begin	begin	VBP
cord-290566-tmsocyfc	23	17	to	to	TO
cord-290566-tmsocyfc	23	18	proliferate	proliferate	VB
cord-290566-tmsocyfc	23	19	,	,	,
cord-290566-tmsocyfc	23	20	diVerentiate	diVerentiate	NNP
cord-290566-tmsocyfc	23	21	,	,	,
cord-290566-tmsocyfc	23	22	and	and	CC
cord-290566-tmsocyfc	23	23	deliver	deliver	VB
cord-290566-tmsocyfc	23	24	a	a	DT
cord-290566-tmsocyfc	23	25	series	series	NN
cord-290566-tmsocyfc	23	26	of	of	IN
cord-290566-tmsocyfc	23	27	signals	signal	NNS
cord-290566-tmsocyfc	23	28	,	,	,
cord-290566-tmsocyfc	23	29	enabling	enable	VBG
cord-290566-tmsocyfc	23	30	eVector	eVector	NNP
cord-290566-tmsocyfc	23	31	functions	function	NNS
cord-290566-tmsocyfc	23	32	to	to	IN
cord-290566-tmsocyfc	23	33	other	other	JJ
cord-290566-tmsocyfc	23	34	cells	cell	NNS
cord-290566-tmsocyfc	23	35	such	such	JJ
cord-290566-tmsocyfc	23	36	as	as	IN
cord-290566-tmsocyfc	23	37	B	b	NN
cord-290566-tmsocyfc	23	38	cells	cell	NNS
cord-290566-tmsocyfc	23	39	and	and	CC
cord-290566-tmsocyfc	23	40	NK	NK	NNP
cord-290566-tmsocyfc	23	41	cells	cell	NNS
cord-290566-tmsocyfc	23	42	.	.	.
cord-290566-tmsocyfc	24	1	T	t	NN
cord-290566-tmsocyfc	24	2	cells	cell	NNS
cord-290566-tmsocyfc	24	3	can	can	MD
cord-290566-tmsocyfc	24	4	thereby	thereby	RB
cord-290566-tmsocyfc	24	5	orchestrate	orchestrate	VB
cord-290566-tmsocyfc	24	6	the	the	DT
cord-290566-tmsocyfc	24	7	immune	immune	JJ
cord-290566-tmsocyfc	24	8	response	response	NN
cord-290566-tmsocyfc	24	9	.	.	.
cord-290566-tmsocyfc	25	1	Costimulatory	costimulatory	NN
cord-290566-tmsocyfc	25	2	molecules	molecule	NNS
cord-290566-tmsocyfc	25	3	may	may	MD
cord-290566-tmsocyfc	25	4	deliver	deliver	VB
cord-290566-tmsocyfc	25	5	either	either	CC
cord-290566-tmsocyfc	25	6	a	a	DT
cord-290566-tmsocyfc	25	7	stimulatory	stimulatory	JJ
cord-290566-tmsocyfc	25	8	(	(	-LRB-
cord-290566-tmsocyfc	25	9	positive	positive	JJ
cord-290566-tmsocyfc	25	10	)	)	-RRB-
cord-290566-tmsocyfc	25	11	or	or	CC
cord-290566-tmsocyfc	25	12	an	an	DT
cord-290566-tmsocyfc	25	13	inhibitory	inhibitory	JJ
cord-290566-tmsocyfc	25	14	(	(	-LRB-
cord-290566-tmsocyfc	25	15	negative	negative	JJ
cord-290566-tmsocyfc	25	16	)	)	-RRB-
cord-290566-tmsocyfc	25	17	signal	signal	NN
cord-290566-tmsocyfc	25	18	for	for	IN
cord-290566-tmsocyfc	25	19	T	t	NN
cord-290566-tmsocyfc	25	20	-	-	HYPH
cord-290566-tmsocyfc	25	21	cell	cell	NN
cord-290566-tmsocyfc	25	22	activation	activation	NN
cord-290566-tmsocyfc	25	23	(	(	-LRB-
cord-290566-tmsocyfc	25	24	Brunet	Brunet	NNP
cord-290566-tmsocyfc	25	25	et	et	NNP
cord-290566-tmsocyfc	25	26	al	al	NNP
cord-290566-tmsocyfc	25	27	.	.	NNP
cord-290566-tmsocyfc	25	28	,	,	,
cord-290566-tmsocyfc	25	29	1987	1987	CD
cord-290566-tmsocyfc	25	30	)	)	-RRB-
cord-290566-tmsocyfc	25	31	.	.	.
cord-290566-tmsocyfc	26	1	Examples	example	NNS
cord-290566-tmsocyfc	26	2	of	of	IN
cord-290566-tmsocyfc	26	3	molecules	molecule	NNS
cord-290566-tmsocyfc	26	4	delivering	deliver	VBG
cord-290566-tmsocyfc	26	5	a	a	DT
cord-290566-tmsocyfc	26	6	positive	positive	JJ
cord-290566-tmsocyfc	26	7	costimulatory	costimulatory	NN
cord-290566-tmsocyfc	26	8	signal	signal	NN
cord-290566-tmsocyfc	26	9	for	for	IN
cord-290566-tmsocyfc	26	10	T	t	NN
cord-290566-tmsocyfc	26	11	-	-	HYPH
cord-290566-tmsocyfc	26	12	cell	cell	NN
cord-290566-tmsocyfc	26	13	activation	activation	NN
cord-290566-tmsocyfc	26	14	include	include	VBP
cord-290566-tmsocyfc	26	15	the	the	DT
cord-290566-tmsocyfc	26	16	B7-CD28	B7-CD28	NNS
cord-290566-tmsocyfc	26	17	and	and	CC
cord-290566-tmsocyfc	26	18	CD40-CD154	CD40-CD154	NNS
cord-290566-tmsocyfc	26	19	pathways	pathway	NNS
cord-290566-tmsocyfc	26	20	.	.	.
cord-290566-tmsocyfc	27	1	Examples	example	NNS
cord-290566-tmsocyfc	27	2	of	of	IN
cord-290566-tmsocyfc	27	3	molecular	molecular	JJ
cord-290566-tmsocyfc	27	4	pathways	pathway	NNS
cord-290566-tmsocyfc	27	5	delivering	deliver	VBG
cord-290566-tmsocyfc	27	6	a	a	DT
cord-290566-tmsocyfc	27	7	negative	negative	JJ
cord-290566-tmsocyfc	27	8	signal	signal	NN
cord-290566-tmsocyfc	27	9	for	for	IN
cord-290566-tmsocyfc	27	10	T	t	NN
cord-290566-tmsocyfc	27	11	-	-	HYPH
cord-290566-tmsocyfc	27	12	cell	cell	NN
cord-290566-tmsocyfc	27	13	activation	activation	NN
cord-290566-tmsocyfc	27	14	include	include	VBP
cord-290566-tmsocyfc	27	15	B7-CTLA4	B7-CTLA4	NNP
cord-290566-tmsocyfc	27	16	and	and	CC
cord-290566-tmsocyfc	27	17	PD1-PD	pd1-pd	NN
cord-290566-tmsocyfc	27	18	ligand	ligand	NN
cord-290566-tmsocyfc	27	19	.	.	.
cord-290566-tmsocyfc	28	1	The	the	DT
cord-290566-tmsocyfc	28	2	delicate	delicate	JJ
cord-290566-tmsocyfc	28	3	balance	balance	NN
cord-290566-tmsocyfc	28	4	between	between	IN
cord-290566-tmsocyfc	28	5	positive	positive	JJ
cord-290566-tmsocyfc	28	6	and	and	CC
cord-290566-tmsocyfc	28	7	negative	negative	JJ
cord-290566-tmsocyfc	28	8	regulatory	regulatory	JJ
cord-290566-tmsocyfc	28	9	signals	signal	NNS
cord-290566-tmsocyfc	28	10	can	can	MD
cord-290566-tmsocyfc	28	11	determine	determine	VB
cord-290566-tmsocyfc	28	12	the	the	DT
cord-290566-tmsocyfc	28	13	outcome	outcome	NN
cord-290566-tmsocyfc	28	14	of	of	IN
cord-290566-tmsocyfc	28	15	a	a	DT
cord-290566-tmsocyfc	28	16	specific	specific	JJ
cord-290566-tmsocyfc	28	17	immune	immune	JJ
cord-290566-tmsocyfc	28	18	response	response	NN
cord-290566-tmsocyfc	28	19	.	.	.
cord-290566-tmsocyfc	29	1	Importantly	importantly	RB
cord-290566-tmsocyfc	29	2	,	,	,
cord-290566-tmsocyfc	29	3	in	in	IN
cord-290566-tmsocyfc	29	4	the	the	DT
cord-290566-tmsocyfc	29	5	absence	absence	NN
cord-290566-tmsocyfc	29	6	of	of	IN
cord-290566-tmsocyfc	29	7	adequate	adequate	JJ
cord-290566-tmsocyfc	29	8	costimulatory	costimulatory	NN
cord-290566-tmsocyfc	29	9	signals	signal	NNS
cord-290566-tmsocyfc	29	10	,	,	,
cord-290566-tmsocyfc	29	11	T	t	NN
cord-290566-tmsocyfc	29	12	cells	cell	NNS
cord-290566-tmsocyfc	29	13	can	can	MD
cord-290566-tmsocyfc	29	14	die	die	VB
cord-290566-tmsocyfc	29	15	or	or	CC
cord-290566-tmsocyfc	29	16	become	become	VB
cord-290566-tmsocyfc	29	17	anergic	anergic	NN
cord-290566-tmsocyfc	29	18	in	in	IN
cord-290566-tmsocyfc	29	19	vitro	vitro	FW
cord-290566-tmsocyfc	29	20	,	,	,
cord-290566-tmsocyfc	29	21	and	and	CC
cord-290566-tmsocyfc	29	22	thus	thus	RB
cord-290566-tmsocyfc	29	23	,	,	,
cord-290566-tmsocyfc	29	24	fail	fail	VB
cord-290566-tmsocyfc	29	25	to	to	TO
cord-290566-tmsocyfc	29	26	initiate	initiate	VB
cord-290566-tmsocyfc	29	27	an	an	DT
cord-290566-tmsocyfc	29	28	eVective	eVective	NNP
cord-290566-tmsocyfc	29	29	immune	immune	JJ
cord-290566-tmsocyfc	29	30	response	response	NN
cord-290566-tmsocyfc	29	31	in	in	IN
cord-290566-tmsocyfc	29	32	vivo	vivo	NNP
cord-290566-tmsocyfc	29	33	.	.	.
cord-290566-tmsocyfc	30	1	Therefore	therefore	RB
cord-290566-tmsocyfc	30	2	,	,	,
cord-290566-tmsocyfc	30	3	manipulation	manipulation	NN
cord-290566-tmsocyfc	30	4	of	of	IN
cord-290566-tmsocyfc	30	5	costimulatory	costimulatory	NNP
cord-290566-tmsocyfc	30	6	signals	signal	NNS
cord-290566-tmsocyfc	30	7	represents	represent	VBZ
cord-290566-tmsocyfc	30	8	an	an	DT
cord-290566-tmsocyfc	30	9	important	important	JJ
cord-290566-tmsocyfc	30	10	mechanism	mechanism	NN
cord-290566-tmsocyfc	30	11	to	to	TO
cord-290566-tmsocyfc	30	12	inhibit	inhibit	VB
cord-290566-tmsocyfc	30	13	immune	immune	JJ
cord-290566-tmsocyfc	30	14	-	-	HYPH
cord-290566-tmsocyfc	30	15	activation	activation	NN
cord-290566-tmsocyfc	30	16	.	.	.
cord-290566-tmsocyfc	31	1	On	on	IN
cord-290566-tmsocyfc	31	2	exposure	exposure	NN
cord-290566-tmsocyfc	31	3	to	to	IN
cord-290566-tmsocyfc	31	4	an	an	DT
cord-290566-tmsocyfc	31	5	antigen	antigen	NN
cord-290566-tmsocyfc	31	6	,	,	,
cord-290566-tmsocyfc	31	7	antigen	antigen	NN
cord-290566-tmsocyfc	31	8	-	-	HYPH
cord-290566-tmsocyfc	31	9	specific	specific	JJ
cord-290566-tmsocyfc	31	10	T	t	NN
cord-290566-tmsocyfc	31	11	cells	cell	NNS
cord-290566-tmsocyfc	31	12	proliferate	proliferate	VBP
cord-290566-tmsocyfc	31	13	and	and	CC
cord-290566-tmsocyfc	31	14	diVerentiate	diVerentiate	NNP
cord-290566-tmsocyfc	31	15	into	into	IN
cord-290566-tmsocyfc	31	16	eVector	eVector	NNP
cord-290566-tmsocyfc	31	17	T	T	NNP
cord-290566-tmsocyfc	31	18	cells	cell	NNS
cord-290566-tmsocyfc	31	19	(	(	-LRB-
cord-290566-tmsocyfc	31	20	Sprent	Sprent	NNP
cord-290566-tmsocyfc	31	21	and	and	CC
cord-290566-tmsocyfc	31	22	Surh	Surh	NNP
cord-290566-tmsocyfc	31	23	,	,	,
cord-290566-tmsocyfc	31	24	2002	2002	CD
cord-290566-tmsocyfc	31	25	)	)	-RRB-
cord-290566-tmsocyfc	31	26	.	.	.
cord-290566-tmsocyfc	32	1	The	the	DT
cord-290566-tmsocyfc	32	2	vast	vast	JJ
cord-290566-tmsocyfc	32	3	majority	majority	NN
cord-290566-tmsocyfc	32	4	of	of	IN
cord-290566-tmsocyfc	32	5	eVector	eVector	NNP
cord-290566-tmsocyfc	32	6	T	T	NNP
cord-290566-tmsocyfc	32	7	cells	cell	NNS
cord-290566-tmsocyfc	32	8	undergo	undergo	VBP
cord-290566-tmsocyfc	32	9	apoptosis	apoptosis	NN
cord-290566-tmsocyfc	32	10	as	as	IN
cord-290566-tmsocyfc	32	11	the	the	DT
cord-290566-tmsocyfc	32	12	immune	immune	JJ
cord-290566-tmsocyfc	32	13	response	response	NN
cord-290566-tmsocyfc	32	14	progresses	progress	VBZ
cord-290566-tmsocyfc	32	15	,	,	,
cord-290566-tmsocyfc	32	16	and	and	CC
cord-290566-tmsocyfc	32	17	the	the	DT
cord-290566-tmsocyfc	32	18	few	few	JJ
cord-290566-tmsocyfc	32	19	lymphocytes	lymphocyte	NNS
cord-290566-tmsocyfc	32	20	that	that	WDT
cord-290566-tmsocyfc	32	21	survive	survive	VBP
cord-290566-tmsocyfc	32	22	become	become	VBP
cord-290566-tmsocyfc	32	23	long	long	RB
cord-290566-tmsocyfc	32	24	-	-	HYPH
cord-290566-tmsocyfc	32	25	lived	live	VBN
cord-290566-tmsocyfc	32	26	memory	memory	NN
cord-290566-tmsocyfc	32	27	T	t	NN
cord-290566-tmsocyfc	32	28	cells	cell	NNS
cord-290566-tmsocyfc	32	29	(	(	-LRB-
cord-290566-tmsocyfc	32	30	Dutton	Dutton	NNP
cord-290566-tmsocyfc	32	31	et	et	NNP
cord-290566-tmsocyfc	32	32	al	al	NNP
cord-290566-tmsocyfc	32	33	.	.	NNP
cord-290566-tmsocyfc	32	34	,	,	,
cord-290566-tmsocyfc	32	35	1998	1998	CD
cord-290566-tmsocyfc	32	36	)	)	-RRB-
cord-290566-tmsocyfc	32	37	.	.	.
cord-290566-tmsocyfc	33	1	Memory	memory	NN
cord-290566-tmsocyfc	33	2	T	t	CD
cord-290566-tmsocyfc	33	3	cells	cell	NNS
cord-290566-tmsocyfc	33	4	are	be	VBP
cord-290566-tmsocyfc	33	5	specific	specific	JJ
cord-290566-tmsocyfc	33	6	to	to	IN
cord-290566-tmsocyfc	33	7	the	the	DT
cord-290566-tmsocyfc	33	8	antigen	antigen	NN
cord-290566-tmsocyfc	33	9	encountered	encounter	VBN
cord-290566-tmsocyfc	33	10	during	during	IN
cord-290566-tmsocyfc	33	11	the	the	DT
cord-290566-tmsocyfc	33	12	primary	primary	JJ
cord-290566-tmsocyfc	33	13	immune	immune	JJ
cord-290566-tmsocyfc	33	14	response	response	NN
cord-290566-tmsocyfc	33	15	and	and	CC
cord-290566-tmsocyfc	33	16	react	react	VBP
cord-290566-tmsocyfc	33	17	rapidly	rapidly	RB
cord-290566-tmsocyfc	33	18	and	and	CC
cord-290566-tmsocyfc	33	19	vigorously	vigorously	RB
cord-290566-tmsocyfc	33	20	on	on	IN
cord-290566-tmsocyfc	33	21	reencounter	reencounter	NNP
cord-290566-tmsocyfc	33	22	with	with	IN
cord-290566-tmsocyfc	33	23	the	the	DT
cord-290566-tmsocyfc	33	24	same	same	JJ
cord-290566-tmsocyfc	33	25	antigen	antigen	NN
cord-290566-tmsocyfc	33	26	.	.	.
cord-290566-tmsocyfc	34	1	Functionally	functionally	RB
cord-290566-tmsocyfc	34	2	,	,	,
cord-290566-tmsocyfc	34	3	in	in	IN
cord-290566-tmsocyfc	34	4	terms	term	NNS
cord-290566-tmsocyfc	34	5	of	of	IN
cord-290566-tmsocyfc	34	6	activation	activation	NN
cord-290566-tmsocyfc	34	7	requirements	requirement	NNS
cord-290566-tmsocyfc	34	8	,	,	,
cord-290566-tmsocyfc	34	9	memory	memory	NN
cord-290566-tmsocyfc	34	10	T	t	NN
cord-290566-tmsocyfc	34	11	cells	cell	NNS
cord-290566-tmsocyfc	34	12	can	can	MD
cord-290566-tmsocyfc	34	13	be	be	VB
cord-290566-tmsocyfc	34	14	activated	activate	VBN
cord-290566-tmsocyfc	34	15	by	by	IN
cord-290566-tmsocyfc	34	16	lower	low	JJR
cord-290566-tmsocyfc	34	17	concentrations	concentration	NNS
cord-290566-tmsocyfc	34	18	of	of	IN
cord-290566-tmsocyfc	34	19	anti	anti	JJ
cord-290566-tmsocyfc	34	20	-	-	JJ
cord-290566-tmsocyfc	34	21	CD3	cd3	JJ
cord-290566-tmsocyfc	34	22	(	(	-LRB-
cord-290566-tmsocyfc	34	23	Byrne	Byrne	NNP
cord-290566-tmsocyfc	34	24	et	et	NNP
cord-290566-tmsocyfc	34	25	al	al	NNP
cord-290566-tmsocyfc	34	26	.	.	NNP
cord-290566-tmsocyfc	34	27	,	,	,
cord-290566-tmsocyfc	34	28	1988	1988	CD
cord-290566-tmsocyfc	34	29	)	)	-RRB-
cord-290566-tmsocyfc	34	30	,	,	,
cord-290566-tmsocyfc	34	31	require	require	VBP
cord-290566-tmsocyfc	34	32	less	less	JJR
cord-290566-tmsocyfc	34	33	costimulation	costimulation	NN
cord-290566-tmsocyfc	34	34	by	by	IN
cord-290566-tmsocyfc	34	35	anti	anti	NNP
cord-290566-tmsocyfc	34	36	-	-	NNP
cord-290566-tmsocyfc	34	37	CD28	CD28	NNP
cord-290566-tmsocyfc	34	38	(	(	-LRB-
cord-290566-tmsocyfc	34	39	Kuiper	Kuiper	NNP
cord-290566-tmsocyfc	34	40	et	et	NNP
cord-290566-tmsocyfc	34	41	al	al	NNP
cord-290566-tmsocyfc	34	42	.	.	NNP
cord-290566-tmsocyfc	34	43	,	,	,
cord-290566-tmsocyfc	34	44	1994	1994	CD
cord-290566-tmsocyfc	34	45	)	)	-RRB-
cord-290566-tmsocyfc	34	46	,	,	,
cord-290566-tmsocyfc	34	47	and	and	CC
cord-290566-tmsocyfc	34	48	readily	readily	RB
cord-290566-tmsocyfc	34	49	secrete	secrete	VB
cord-290566-tmsocyfc	34	50	more	more	JJR
cord-290566-tmsocyfc	34	51	eVector	eVector	NNP
cord-290566-tmsocyfc	34	52	cytokines	cytokine	NNS
cord-290566-tmsocyfc	34	53	(	(	-LRB-
cord-290566-tmsocyfc	34	54	Bird	Bird	NNP
cord-290566-tmsocyfc	34	55	et	et	NNP
cord-290566-tmsocyfc	34	56	al	al	NNP
cord-290566-tmsocyfc	34	57	.	.	NNP
cord-290566-tmsocyfc	34	58	,	,	,
cord-290566-tmsocyfc	34	59	1998	1998	CD
cord-290566-tmsocyfc	34	60	;	;	:
cord-290566-tmsocyfc	34	61	Ehlers	Ehlers	NNP
cord-290566-tmsocyfc	34	62	and	and	CC
cord-290566-tmsocyfc	34	63	Smith	Smith	NNP
cord-290566-tmsocyfc	34	64	,	,	,
cord-290566-tmsocyfc	34	65	1991	1991	CD
cord-290566-tmsocyfc	34	66	;	;	:
cord-290566-tmsocyfc	34	67	Lee	Lee	NNP
cord-290566-tmsocyfc	34	68	et	et	NNP
cord-290566-tmsocyfc	34	69	al	al	NNP
cord-290566-tmsocyfc	34	70	.	.	NNP
cord-290566-tmsocyfc	34	71	,	,	,
cord-290566-tmsocyfc	34	72	1990	1990	CD
cord-290566-tmsocyfc	34	73	)	)	-RRB-
cord-290566-tmsocyfc	34	74	than	than	IN
cord-290566-tmsocyfc	34	75	naive	naive	JJ
cord-290566-tmsocyfc	34	76	T	t	NN
cord-290566-tmsocyfc	34	77	-	-	HYPH
cord-290566-tmsocyfc	34	78	cell	cell	NN
cord-290566-tmsocyfc	34	79	counterparts	counterpart	NNS
cord-290566-tmsocyfc	34	80	,	,	,
cord-290566-tmsocyfc	34	81	indicating	indicate	VBG
cord-290566-tmsocyfc	34	82	a	a	DT
cord-290566-tmsocyfc	34	83	state	state	NN
cord-290566-tmsocyfc	34	84	of	of	IN
cord-290566-tmsocyfc	34	85	hyperresponsiveness	hyperresponsiveness	NN
cord-290566-tmsocyfc	34	86	.	.	.
cord-290566-tmsocyfc	35	1	Molecules	molecule	NNS
cord-290566-tmsocyfc	35	2	primarily	primarily	RB
cord-290566-tmsocyfc	35	3	involved	involve	VBN
cord-290566-tmsocyfc	35	4	in	in	IN
cord-290566-tmsocyfc	35	5	cell	cell	NN
cord-290566-tmsocyfc	35	6	migration	migration	NN
cord-290566-tmsocyfc	35	7	into	into	IN
cord-290566-tmsocyfc	35	8	tissues	tissue	NNS
cord-290566-tmsocyfc	35	9	include	include	VBP
cord-290566-tmsocyfc	35	10	chemokines	chemokine	NNS
cord-290566-tmsocyfc	35	11	,	,	,
cord-290566-tmsocyfc	35	12	integrins	integrin	NNS
cord-290566-tmsocyfc	35	13	,	,	,
cord-290566-tmsocyfc	35	14	selectins	selectin	NNS
cord-290566-tmsocyfc	35	15	,	,	,
cord-290566-tmsocyfc	35	16	and	and	CC
cord-290566-tmsocyfc	35	17	matrix	matrix	NN
cord-290566-tmsocyfc	35	18	metalloproteinases	metalloproteinase	NNS
cord-290566-tmsocyfc	35	19	(	(	-LRB-
cord-290566-tmsocyfc	35	20	MMPs	MMPs	NNP
cord-290566-tmsocyfc	35	21	)	)	-RRB-
cord-290566-tmsocyfc	35	22	.	.	.
cord-290566-tmsocyfc	36	1	Chemokines	Chemokines	NNPS
cord-290566-tmsocyfc	36	2	constitute	constitute	VBP
cord-290566-tmsocyfc	36	3	a	a	DT
cord-290566-tmsocyfc	36	4	large	large	JJ
cord-290566-tmsocyfc	36	5	family	family	NN
cord-290566-tmsocyfc	36	6	of	of	IN
cord-290566-tmsocyfc	36	7	chemoattractant	chemoattractant	NN
cord-290566-tmsocyfc	36	8	peptides	peptide	NNS
cord-290566-tmsocyfc	36	9	that	that	WDT
cord-290566-tmsocyfc	36	10	regulate	regulate	VBP
cord-290566-tmsocyfc	36	11	the	the	DT
cord-290566-tmsocyfc	36	12	vast	vast	JJ
cord-290566-tmsocyfc	36	13	spectrum	spectrum	NN
cord-290566-tmsocyfc	36	14	of	of	IN
cord-290566-tmsocyfc	36	15	leukocyte	leukocyte	NN
cord-290566-tmsocyfc	36	16	migration	migration	NN
cord-290566-tmsocyfc	36	17	events	event	NNS
cord-290566-tmsocyfc	36	18	through	through	IN
cord-290566-tmsocyfc	36	19	interactions	interaction	NNS
cord-290566-tmsocyfc	36	20	with	with	IN
cord-290566-tmsocyfc	36	21	chemokine	chemokine	NN
cord-290566-tmsocyfc	36	22	receptors	receptor	NNS
cord-290566-tmsocyfc	36	23	.	.	.
cord-290566-tmsocyfc	37	1	The	the	DT
cord-290566-tmsocyfc	37	2	integrin	integrin	NN
cord-290566-tmsocyfc	37	3	family	family	NN
cord-290566-tmsocyfc	37	4	includes	include	VBZ
cord-290566-tmsocyfc	37	5	vascular	vascular	JJ
cord-290566-tmsocyfc	37	6	cell	cell	NN
cord-290566-tmsocyfc	37	7	adhesion	adhesion	NN
cord-290566-tmsocyfc	37	8	molecule-1	molecule-1	NNP
cord-290566-tmsocyfc	37	9	(	(	-LRB-
cord-290566-tmsocyfc	37	10	VCAM-1	VCAM-1	NNP
cord-290566-tmsocyfc	37	11	)	)	-RRB-
cord-290566-tmsocyfc	37	12	,	,	,
cord-290566-tmsocyfc	37	13	intercellular	intercellular	JJ
cord-290566-tmsocyfc	37	14	adhesion	adhesion	NN
cord-290566-tmsocyfc	37	15	molecule-1	molecule-1	NN
cord-290566-tmsocyfc	37	16	(	(	-LRB-
cord-290566-tmsocyfc	37	17	ICAM-1	ICAM-1	NNP
cord-290566-tmsocyfc	37	18	)	)	-RRB-
cord-290566-tmsocyfc	37	19	,	,	,
cord-290566-tmsocyfc	37	20	and	and	CC
cord-290566-tmsocyfc	37	21	leukocyte	leukocyte	NN
cord-290566-tmsocyfc	37	22	function	function	NN
cord-290566-tmsocyfc	37	23	antigen	antigen	NNP
cord-290566-tmsocyfc	37	24	3	3	CD
cord-290566-tmsocyfc	37	25	(	(	-LRB-
cord-290566-tmsocyfc	37	26	LFA-3	LFA-3	NNP
cord-290566-tmsocyfc	37	27	)	)	-RRB-
cord-290566-tmsocyfc	37	28	,	,	,
cord-290566-tmsocyfc	37	29	CD45	CD45	NNP
cord-290566-tmsocyfc	37	30	,	,	,
cord-290566-tmsocyfc	37	31	and	and	CC
cord-290566-tmsocyfc	37	32	CD2	CD2	NNP
cord-290566-tmsocyfc	37	33	.	.	.
cord-290566-tmsocyfc	38	1	The	the	DT
cord-290566-tmsocyfc	38	2	integrin	integrin	JJ
cord-290566-tmsocyfc	38	3	family	family	NN
cord-290566-tmsocyfc	38	4	also	also	RB
cord-290566-tmsocyfc	38	5	mediates	mediate	VBZ
cord-290566-tmsocyfc	38	6	T	t	NN
cord-290566-tmsocyfc	38	7	-	-	HYPH
cord-290566-tmsocyfc	38	8	cell	cell	NN
cord-290566-tmsocyfc	38	9	adhesion	adhesion	NN
cord-290566-tmsocyfc	38	10	,	,	,
cord-290566-tmsocyfc	38	11	facilitates	facilitate	VBZ
cord-290566-tmsocyfc	38	12	interaction	interaction	NN
cord-290566-tmsocyfc	38	13	with	with	IN
cord-290566-tmsocyfc	38	14	the	the	DT
cord-290566-tmsocyfc	38	15	APCs	apc	NNS
cord-290566-tmsocyfc	38	16	,	,	,
cord-290566-tmsocyfc	38	17	as	as	RB
cord-290566-tmsocyfc	38	18	well	well	RB
cord-290566-tmsocyfc	38	19	mediates	mediate	VBZ
cord-290566-tmsocyfc	38	20	adhesion	adhesion	NN
cord-290566-tmsocyfc	38	21	to	to	IN
cord-290566-tmsocyfc	38	22	nonhematopoietic	nonhematopoietic	JJ
cord-290566-tmsocyfc	38	23	cells	cell	NNS
cord-290566-tmsocyfc	38	24	such	such	JJ
cord-290566-tmsocyfc	38	25	as	as	IN
cord-290566-tmsocyfc	38	26	endothelial	endothelial	JJ
cord-290566-tmsocyfc	38	27	cells	cell	NNS
cord-290566-tmsocyfc	38	28	and	and	CC
cord-290566-tmsocyfc	38	29	guides	guide	VBZ
cord-290566-tmsocyfc	38	30	cell	cell	NN
cord-290566-tmsocyfc	38	31	traYc	trayc	CD
cord-290566-tmsocyfc	38	32	.	.	.
cord-290566-tmsocyfc	39	1	L	L	NNP
cord-290566-tmsocyfc	39	2	-	-	HYPH
cord-290566-tmsocyfc	39	3	Selectins	Selectins	NNP
cord-290566-tmsocyfc	39	4	facilitate	facilitate	VBP
cord-290566-tmsocyfc	39	5	the	the	DT
cord-290566-tmsocyfc	39	6	rolling	rolling	NN
cord-290566-tmsocyfc	39	7	of	of	IN
cord-290566-tmsocyfc	39	8	leucocytes	leucocyte	NNS
cord-290566-tmsocyfc	39	9	along	along	IN
cord-290566-tmsocyfc	39	10	the	the	DT
cord-290566-tmsocyfc	39	11	surface	surface	NN
cord-290566-tmsocyfc	39	12	of	of	IN
cord-290566-tmsocyfc	39	13	endothelial	endothelial	JJ
cord-290566-tmsocyfc	39	14	cells	cell	NNS
cord-290566-tmsocyfc	39	15	and	and	CC
cord-290566-tmsocyfc	39	16	function	function	VBP
cord-290566-tmsocyfc	39	17	as	as	IN
cord-290566-tmsocyfc	39	18	a	a	DT
cord-290566-tmsocyfc	39	19	homing	homing	NN
cord-290566-tmsocyfc	39	20	receptor	receptor	NN
cord-290566-tmsocyfc	39	21	to	to	TO
cord-290566-tmsocyfc	39	22	target	target	VB
cord-290566-tmsocyfc	39	23	peripheral	peripheral	JJ
cord-290566-tmsocyfc	39	24	lymphoid	lymphoid	JJ
cord-290566-tmsocyfc	39	25	organs	organ	NNS
cord-290566-tmsocyfc	39	26	.	.	.
cord-290566-tmsocyfc	40	1	The	the	DT
cord-290566-tmsocyfc	40	2	MMPs	mmp	NNS
cord-290566-tmsocyfc	40	3	are	be	VBP
cord-290566-tmsocyfc	40	4	a	a	DT
cord-290566-tmsocyfc	40	5	family	family	NN
cord-290566-tmsocyfc	40	6	of	of	IN
cord-290566-tmsocyfc	40	7	proteinases	proteinases	NNP
cord-290566-tmsocyfc	40	8	,	,	,
cord-290566-tmsocyfc	40	9	secreted	secrete	VBN
cord-290566-tmsocyfc	40	10	by	by	IN
cord-290566-tmsocyfc	40	11	inflammatory	inflammatory	JJ
cord-290566-tmsocyfc	40	12	cells	cell	NNS
cord-290566-tmsocyfc	40	13	,	,	,
cord-290566-tmsocyfc	40	14	which	which	WDT
cord-290566-tmsocyfc	40	15	digest	digest	VBP
cord-290566-tmsocyfc	40	16	specific	specific	JJ
cord-290566-tmsocyfc	40	17	components	component	NNS
cord-290566-tmsocyfc	40	18	of	of	IN
cord-290566-tmsocyfc	40	19	the	the	DT
cord-290566-tmsocyfc	40	20	extracellular	extracellular	JJ
cord-290566-tmsocyfc	40	21	matrix	matrix	NN
cord-290566-tmsocyfc	40	22	,	,	,
cord-290566-tmsocyfc	40	23	thereby	thereby	RB
cord-290566-tmsocyfc	40	24	facilitating	facilitate	VBG
cord-290566-tmsocyfc	40	25	lymphocyte	lymphocyte	NN
cord-290566-tmsocyfc	40	26	entry	entry	NN
cord-290566-tmsocyfc	40	27	through	through	IN
cord-290566-tmsocyfc	40	28	basement	basement	NN
cord-290566-tmsocyfc	40	29	membranes	membrane	NNS
cord-290566-tmsocyfc	40	30	,	,	,
cord-290566-tmsocyfc	40	31	including	include	VBG
cord-290566-tmsocyfc	40	32	the	the	DT
cord-290566-tmsocyfc	40	33	blood	blood	NN
cord-290566-tmsocyfc	40	34	-	-	HYPH
cord-290566-tmsocyfc	40	35	brain	brain	NN
cord-290566-tmsocyfc	40	36	barrier	barrier	NN
cord-290566-tmsocyfc	40	37	(	(	-LRB-
cord-290566-tmsocyfc	40	38	BBB	BBB	NNP
cord-290566-tmsocyfc	40	39	)	)	-RRB-
cord-290566-tmsocyfc	40	40	.	.	.
cord-290566-tmsocyfc	41	1	The	the	DT
cord-290566-tmsocyfc	41	2	Th	Th	NNP
cord-290566-tmsocyfc	41	3	cells	cell	NNS
cord-290566-tmsocyfc	41	4	play	play	VBP
cord-290566-tmsocyfc	41	5	a	a	DT
cord-290566-tmsocyfc	41	6	critical	critical	JJ
cord-290566-tmsocyfc	41	7	role	role	NN
cord-290566-tmsocyfc	41	8	in	in	IN
cord-290566-tmsocyfc	41	9	the	the	DT
cord-290566-tmsocyfc	41	10	orchestration	orchestration	NN
cord-290566-tmsocyfc	41	11	of	of	IN
cord-290566-tmsocyfc	41	12	the	the	DT
cord-290566-tmsocyfc	41	13	immune	immune	JJ
cord-290566-tmsocyfc	41	14	response	response	NN
cord-290566-tmsocyfc	41	15	,	,	,
cord-290566-tmsocyfc	41	16	in	in	IN
cord-290566-tmsocyfc	41	17	part	part	NN
cord-290566-tmsocyfc	41	18	,	,	,
cord-290566-tmsocyfc	41	19	through	through	IN
cord-290566-tmsocyfc	41	20	the	the	DT
cord-290566-tmsocyfc	41	21	production	production	NN
cord-290566-tmsocyfc	41	22	of	of	IN
cord-290566-tmsocyfc	41	23	cytokines	cytokine	NNS
cord-290566-tmsocyfc	41	24	that	that	WDT
cord-290566-tmsocyfc	41	25	provide	provide	VBP
cord-290566-tmsocyfc	41	26	secondary	secondary	JJ
cord-290566-tmsocyfc	41	27	signals	signal	NNS
cord-290566-tmsocyfc	41	28	to	to	IN
cord-290566-tmsocyfc	41	29	other	other	JJ
cord-290566-tmsocyfc	41	30	cells	cell	NNS
cord-290566-tmsocyfc	41	31	in	in	IN
cord-290566-tmsocyfc	41	32	the	the	DT
cord-290566-tmsocyfc	41	33	immune	immune	JJ
cord-290566-tmsocyfc	41	34	cascade	cascade	NN
cord-290566-tmsocyfc	41	35	.	.	.
cord-290566-tmsocyfc	42	1	Two	two	CD
cord-290566-tmsocyfc	42	2	major	major	JJ
cord-290566-tmsocyfc	42	3	types	type	NNS
cord-290566-tmsocyfc	42	4	of	of	IN
cord-290566-tmsocyfc	42	5	Th	Th	NNP
cord-290566-tmsocyfc	42	6	cell	cell	NN
cord-290566-tmsocyfc	42	7	responses	response	NNS
cord-290566-tmsocyfc	42	8	have	have	VBP
cord-290566-tmsocyfc	42	9	been	be	VBN
cord-290566-tmsocyfc	42	10	described	describe	VBN
cord-290566-tmsocyfc	42	11	.	.	.
cord-290566-tmsocyfc	43	1	Th1	th1	NN
cord-290566-tmsocyfc	43	2	cells	cell	NNS
cord-290566-tmsocyfc	43	3	produce	produce	VBP
cord-290566-tmsocyfc	43	4	IL-2	il-2	NN
cord-290566-tmsocyfc	43	5	,	,	,
cord-290566-tmsocyfc	43	6	TNF-	TNF-	NNP
cord-290566-tmsocyfc	43	7	,	,	,
cord-290566-tmsocyfc	43	8	and	and	CC
cord-290566-tmsocyfc	43	9	interferon	interferon	NN
cord-290566-tmsocyfc	43	10	(	(	-LRB-
cord-290566-tmsocyfc	43	11	IFN)-	IFN)-	NNP
cord-290566-tmsocyfc	43	12	,	,	,
cord-290566-tmsocyfc	43	13	while	while	IN
cord-290566-tmsocyfc	43	14	Th2	th2	CD
cord-290566-tmsocyfc	43	15	cells	cell	NNS
cord-290566-tmsocyfc	43	16	produce	produce	VBP
cord-290566-tmsocyfc	43	17	IL-4	IL-4	NNP
cord-290566-tmsocyfc	43	18	,	,	,
cord-290566-tmsocyfc	43	19	IL-5	IL-5	NNP
cord-290566-tmsocyfc	43	20	,	,	,
cord-290566-tmsocyfc	43	21	IL-10	IL-10	NNP
cord-290566-tmsocyfc	43	22	,	,	,
cord-290566-tmsocyfc	43	23	and	and	CC
cord-290566-tmsocyfc	43	24	IL-13	IL-13	NNP
cord-290566-tmsocyfc	43	25	.	.	.
cord-290566-tmsocyfc	44	1	A	a	DT
cord-290566-tmsocyfc	44	2	Th3	th3	CD
cord-290566-tmsocyfc	44	3	cell	cell	NN
cord-290566-tmsocyfc	44	4	that	that	WDT
cord-290566-tmsocyfc	44	5	primarily	primarily	RB
cord-290566-tmsocyfc	44	6	secretes	secrete	VBZ
cord-290566-tmsocyfc	44	7	TGF	TGF	NNP
cord-290566-tmsocyfc	44	8	-	-	:
cord-290566-tmsocyfc	44	9	has	have	VBZ
cord-290566-tmsocyfc	44	10	been	be	VBN
cord-290566-tmsocyfc	44	11	described	describe	VBN
cord-290566-tmsocyfc	44	12	in	in	IN
cord-290566-tmsocyfc	44	13	the	the	DT
cord-290566-tmsocyfc	44	14	context	context	NN
cord-290566-tmsocyfc	44	15	of	of	IN
cord-290566-tmsocyfc	44	16	oral	oral	JJ
cord-290566-tmsocyfc	44	17	tolerance	tolerance	NN
cord-290566-tmsocyfc	44	18	to	to	IN
cord-290566-tmsocyfc	44	19	myelin	myelin	NN
cord-290566-tmsocyfc	44	20	antigens	antigen	NNS
cord-290566-tmsocyfc	44	21	(	(	-LRB-
cord-290566-tmsocyfc	44	22	Fukaura	Fukaura	NNP
cord-290566-tmsocyfc	44	23	et	et	FW
cord-290566-tmsocyfc	44	24	al	al	NNP
cord-290566-tmsocyfc	44	25	.	.	NNP
cord-290566-tmsocyfc	44	26	,	,	,
cord-290566-tmsocyfc	44	27	1996	1996	CD
cord-290566-tmsocyfc	44	28	;	;	:
cord-290566-tmsocyfc	44	29	Hafler	Hafler	NNP
cord-290566-tmsocyfc	44	30	et	et	NNP
cord-290566-tmsocyfc	44	31	al	al	NNP
cord-290566-tmsocyfc	44	32	.	.	NNP
cord-290566-tmsocyfc	44	33	,	,	,
cord-290566-tmsocyfc	44	34	1997	1997	CD
cord-290566-tmsocyfc	44	35	)	)	-RRB-
cord-290566-tmsocyfc	44	36	and	and	CC
cord-290566-tmsocyfc	44	37	in	in	IN
cord-290566-tmsocyfc	44	38	other	other	JJ
cord-290566-tmsocyfc	44	39	immune	immune	NN
cord-290566-tmsocyfc	44	40	-	-	HYPH
cord-290566-tmsocyfc	44	41	mediated	mediate	VBN
cord-290566-tmsocyfc	44	42	settings	setting	NNS
cord-290566-tmsocyfc	44	43	(	(	-LRB-
cord-290566-tmsocyfc	44	44	Minguela	Minguela	NNP
cord-290566-tmsocyfc	44	45	et	et	NNP
cord-290566-tmsocyfc	44	46	al	al	NNP
cord-290566-tmsocyfc	44	47	.	.	NNP
cord-290566-tmsocyfc	44	48	,	,	,
cord-290566-tmsocyfc	44	49	1999	1999	CD
cord-290566-tmsocyfc	44	50	)	)	-RRB-
cord-290566-tmsocyfc	44	51	.	.	.
cord-290566-tmsocyfc	45	1	These	these	DT
cord-290566-tmsocyfc	45	2	subsets	subset	NNS
cord-290566-tmsocyfc	45	3	of	of	IN
cord-290566-tmsocyfc	45	4	T	T	NNP
cord-290566-tmsocyfc	45	5	cells	cell	NNS
cord-290566-tmsocyfc	45	6	interregulate	interregulate	VBP
cord-290566-tmsocyfc	45	7	each	each	DT
cord-290566-tmsocyfc	45	8	other	other	JJ
cord-290566-tmsocyfc	45	9	's	's	POS
cord-290566-tmsocyfc	45	10	development	development	NN
cord-290566-tmsocyfc	45	11	,	,	,
cord-290566-tmsocyfc	45	12	with	with	IN
cord-290566-tmsocyfc	45	13	Th1	th1	NN
cord-290566-tmsocyfc	45	14	cytokines	cytokine	NNS
cord-290566-tmsocyfc	45	15	suppressing	suppress	VBG
cord-290566-tmsocyfc	45	16	Th2	th2	CD
cord-290566-tmsocyfc	45	17	diVerentiation	diverentiation	NN
cord-290566-tmsocyfc	45	18	and	and	CC
cord-290566-tmsocyfc	45	19	vice	vice	NN
cord-290566-tmsocyfc	45	20	versa	versa	RB
cord-290566-tmsocyfc	45	21	(	(	-LRB-
cord-290566-tmsocyfc	45	22	Fig	Fig	NNP
cord-290566-tmsocyfc	45	23	.	.	.
cord-290566-tmsocyfc	45	24	1	1	CD
cord-290566-tmsocyfc	45	25	)	)	-RRB-
cord-290566-tmsocyfc	45	26	.	.	.
cord-290566-tmsocyfc	46	1	A	a	DT
cord-290566-tmsocyfc	46	2	subset	subset	NN
cord-290566-tmsocyfc	46	3	of	of	IN
cord-290566-tmsocyfc	46	4	T	t	NN
cord-290566-tmsocyfc	46	5	cells	cell	NNS
cord-290566-tmsocyfc	46	6	that	that	WDT
cord-290566-tmsocyfc	46	7	predominantly	predominantly	RB
cord-290566-tmsocyfc	46	8	produces	produce	VBZ
cord-290566-tmsocyfc	46	9	IL-17	IL-17	NNP
cord-290566-tmsocyfc	46	10	has	have	VBZ
cord-290566-tmsocyfc	46	11	been	be	VBN
cord-290566-tmsocyfc	46	12	described	describe	VBN
cord-290566-tmsocyfc	46	13	(	(	-LRB-
cord-290566-tmsocyfc	46	14	Yao	Yao	NNP
cord-290566-tmsocyfc	46	15	et	et	FW
cord-290566-tmsocyfc	46	16	al	al	NNP
cord-290566-tmsocyfc	46	17	.	.	NNP
cord-290566-tmsocyfc	46	18	,	,	,
cord-290566-tmsocyfc	46	19	1995	1995	CD
cord-290566-tmsocyfc	46	20	)	)	-RRB-
cord-290566-tmsocyfc	46	21	.	.	.
cord-290566-tmsocyfc	47	1	These	these	DT
cord-290566-tmsocyfc	47	2	cells	cell	NNS
cord-290566-tmsocyfc	47	3	are	be	VBP
cord-290566-tmsocyfc	47	4	believed	believe	VBN
cord-290566-tmsocyfc	47	5	to	to	TO
cord-290566-tmsocyfc	47	6	represent	represent	VB
cord-290566-tmsocyfc	47	7	a	a	DT
cord-290566-tmsocyfc	47	8	distinct	distinct	JJ
cord-290566-tmsocyfc	47	9	subset	subset	NN
cord-290566-tmsocyfc	47	10	from	from	IN
cord-290566-tmsocyfc	47	11	IFN	IFN	NNP
cord-290566-tmsocyfc	47	12	--	--	:
cord-290566-tmsocyfc	47	13	producing	produce	VBG
cord-290566-tmsocyfc	47	14	Th1	th1	NN
cord-290566-tmsocyfc	47	15	cells	cell	NNS
cord-290566-tmsocyfc	47	16	,	,	,
cord-290566-tmsocyfc	47	17	evidenced	evidence	VBN
cord-290566-tmsocyfc	47	18	by	by	IN
cord-290566-tmsocyfc	47	19	the	the	DT
cord-290566-tmsocyfc	47	20	dependence	dependence	NN
cord-290566-tmsocyfc	47	21	of	of	IN
cord-290566-tmsocyfc	47	22	Th	Th	NNP
cord-290566-tmsocyfc	47	23	IL-17	IL-17	NNP
cord-290566-tmsocyfc	47	24	cells	cell	NNS
cord-290566-tmsocyfc	47	25	on	on	IN
cord-290566-tmsocyfc	47	26	IL-16	IL-16	NNP
cord-290566-tmsocyfc	47	27	and	and	CC
cord-290566-tmsocyfc	47	28	TGF	TGF	NNP
cord-290566-tmsocyfc	47	29	-	-	HYPH
cord-290566-tmsocyfc	47	30	for	for	IN
cord-290566-tmsocyfc	47	31	diVerentiation	diverentiation	NN
cord-290566-tmsocyfc	47	32	(	(	-LRB-
cord-290566-tmsocyfc	47	33	Bettelli	Bettelli	NNP
cord-290566-tmsocyfc	47	34	et	et	FW
cord-290566-tmsocyfc	47	35	al	al	NNP
cord-290566-tmsocyfc	47	36	.	.	NNP
cord-290566-tmsocyfc	47	37	,	,	,
cord-290566-tmsocyfc	47	38	2006	2006	CD
cord-290566-tmsocyfc	47	39	;	;	:
cord-290566-tmsocyfc	47	40	Mangan	Mangan	NNP
cord-290566-tmsocyfc	47	41	et	et	NNP
cord-290566-tmsocyfc	47	42	al	al	NNP
cord-290566-tmsocyfc	47	43	.	.	NNP
cord-290566-tmsocyfc	47	44	,	,	,
cord-290566-tmsocyfc	47	45	2006	2006	CD
cord-290566-tmsocyfc	47	46	;	;	:
cord-290566-tmsocyfc	47	47	Veldhoen	Veldhoen	NNP
cord-290566-tmsocyfc	47	48	et	et	NNP
cord-290566-tmsocyfc	47	49	al	al	NNP
cord-290566-tmsocyfc	47	50	.	.	NNP
cord-290566-tmsocyfc	47	51	,	,	,
cord-290566-tmsocyfc	47	52	2006	2006	CD
cord-290566-tmsocyfc	47	53	)	)	-RRB-
cord-290566-tmsocyfc	47	54	and	and	CC
cord-290566-tmsocyfc	47	55	IL-23	IL-23	NNP
cord-290566-tmsocyfc	47	56	for	for	IN
cord-290566-tmsocyfc	47	57	expansion	expansion	NN
cord-290566-tmsocyfc	47	58	(	(	-LRB-
cord-290566-tmsocyfc	48	1	Aggarwal	Aggarwal	NNP
cord-290566-tmsocyfc	48	2	et	et	NNP
cord-290566-tmsocyfc	48	3	al	al	NNP
cord-290566-tmsocyfc	48	4	.	.	.
cord-290566-tmsocyfc	49	1	,	,	,
cord-290566-tmsocyfc	49	2	2003	2003	CD
cord-290566-tmsocyfc	49	3	;	;	:
cord-290566-tmsocyfc	49	4	Langrish	Langrish	NNP
cord-290566-tmsocyfc	49	5	et	et	NNP
cord-290566-tmsocyfc	49	6	al	al	NNP
cord-290566-tmsocyfc	49	7	.	.	NNP
cord-290566-tmsocyfc	49	8	,	,	,
cord-290566-tmsocyfc	49	9	2005	2005	CD
cord-290566-tmsocyfc	49	10	)	)	-RRB-
cord-290566-tmsocyfc	49	11	,	,	,
cord-290566-tmsocyfc	49	12	as	as	IN
cord-290566-tmsocyfc	49	13	opposed	oppose	VBN
cord-290566-tmsocyfc	49	14	to	to	IN
cord-290566-tmsocyfc	49	15	Th1	th1	NN
cord-290566-tmsocyfc	49	16	cells	cell	NNS
cord-290566-tmsocyfc	49	17	which	which	WDT
cord-290566-tmsocyfc	49	18	are	be	VBP
cord-290566-tmsocyfc	49	19	dependent	dependent	JJ
cord-290566-tmsocyfc	49	20	on	on	IN
cord-290566-tmsocyfc	49	21	IL-12	IL-12	NNP
cord-290566-tmsocyfc	49	22	and	and	CC
cord-290566-tmsocyfc	49	23	IL-2	IL-2	NNP
cord-290566-tmsocyfc	49	24	,	,	,
cord-290566-tmsocyfc	49	25	respectively	respectively	RB
cord-290566-tmsocyfc	49	26	,	,	,
cord-290566-tmsocyfc	49	27	for	for	IN
cord-290566-tmsocyfc	49	28	diVerentiation	diverentiation	NN
cord-290566-tmsocyfc	49	29	and	and	CC
cord-290566-tmsocyfc	49	30	expansion	expansion	NN
cord-290566-tmsocyfc	49	31	.	.	.
cord-290566-tmsocyfc	50	1	Both	both	DT
cord-290566-tmsocyfc	50	2	Th1	th1	NN
cord-290566-tmsocyfc	50	3	and	and	CC
cord-290566-tmsocyfc	50	4	Th2	th2	CD
cord-290566-tmsocyfc	50	5	cytokines	cytokine	NNS
cord-290566-tmsocyfc	50	6	have	have	VBP
cord-290566-tmsocyfc	50	7	been	be	VBN
cord-290566-tmsocyfc	50	8	shown	show	VBN
cord-290566-tmsocyfc	50	9	to	to	TO
cord-290566-tmsocyfc	50	10	suppress	suppress	VB
cord-290566-tmsocyfc	50	11	the	the	DT
cord-290566-tmsocyfc	50	12	development	development	NN
cord-290566-tmsocyfc	50	13	of	of	IN
cord-290566-tmsocyfc	50	14	Th17	Th17	NNP
cord-290566-tmsocyfc	50	15	cells	cell	NNS
cord-290566-tmsocyfc	50	16	(	(	-LRB-
cord-290566-tmsocyfc	50	17	Harrington	Harrington	NNP
cord-290566-tmsocyfc	50	18	et	et	NNP
cord-290566-tmsocyfc	50	19	al	al	NNP
cord-290566-tmsocyfc	50	20	.	.	NNP
cord-290566-tmsocyfc	50	21	,	,	,
cord-290566-tmsocyfc	50	22	2005	2005	CD
cord-290566-tmsocyfc	50	23	;	;	:
cord-290566-tmsocyfc	50	24	Park	Park	NNP
cord-290566-tmsocyfc	50	25	et	et	FW
cord-290566-tmsocyfc	50	26	al	al	NNP
cord-290566-tmsocyfc	50	27	.	.	NNP
cord-290566-tmsocyfc	50	28	,	,	,
cord-290566-tmsocyfc	50	29	2005	2005	CD
cord-290566-tmsocyfc	50	30	)	)	-RRB-
cord-290566-tmsocyfc	50	31	.	.	.
cord-290566-tmsocyfc	51	1	An	an	DT
cord-290566-tmsocyfc	51	2	intriguing	intriguing	JJ
cord-290566-tmsocyfc	51	3	relationship	relationship	NN
cord-290566-tmsocyfc	51	4	between	between	IN
cord-290566-tmsocyfc	51	5	the	the	DT
cord-290566-tmsocyfc	51	6	generation	generation	NN
cord-290566-tmsocyfc	51	7	of	of	IN
cord-290566-tmsocyfc	51	8	pathogenic	pathogenic	JJ
cord-290566-tmsocyfc	51	9	Th17	Th17	NNP
cord-290566-tmsocyfc	51	10	and	and	CC
cord-290566-tmsocyfc	51	11	regulatory	regulatory	JJ
cord-290566-tmsocyfc	51	12	CD4þCD25þFoxp3þ	CD4þCD25þFoxp3þ	NNP
cord-290566-tmsocyfc	51	13	cells	cell	NNS
cord-290566-tmsocyfc	51	14	has	have	VBZ
cord-290566-tmsocyfc	51	15	recently	recently	RB
cord-290566-tmsocyfc	51	16	been	be	VBN
cord-290566-tmsocyfc	51	17	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	51	18	.	.	.
cord-290566-tmsocyfc	52	1	TGFis	tgfis	PRP
cord-290566-tmsocyfc	52	2	critical	critical	JJ
cord-290566-tmsocyfc	52	3	for	for	IN
cord-290566-tmsocyfc	52	4	the	the	DT
cord-290566-tmsocyfc	52	5	diVerentiation	diverentiation	NN
cord-290566-tmsocyfc	52	6	and	and	CC
cord-290566-tmsocyfc	52	7	generation	generation	NN
cord-290566-tmsocyfc	52	8	of	of	IN
cord-290566-tmsocyfc	52	9	CD4þCD25þFoxp3þ	CD4þCD25þFoxp3þ	NNP
cord-290566-tmsocyfc	52	10	regulatory	regulatory	JJ
cord-290566-tmsocyfc	52	11	T	t	NN
cord-290566-tmsocyfc	52	12	cells	cell	NNS
cord-290566-tmsocyfc	52	13	;	;	:
cord-290566-tmsocyfc	52	14	however	however	RB
cord-290566-tmsocyfc	52	15	,	,	,
cord-290566-tmsocyfc	52	16	if	if	IN
cord-290566-tmsocyfc	52	17	additionally	additionally	RB
cord-290566-tmsocyfc	52	18	exposed	expose	VBN
cord-290566-tmsocyfc	52	19	to	to	IN
cord-290566-tmsocyfc	52	20	IL-6	IL-6	NNP
cord-290566-tmsocyfc	52	21	during	during	IN
cord-290566-tmsocyfc	52	22	culture	culture	NN
cord-290566-tmsocyfc	52	23	,	,	,
cord-290566-tmsocyfc	52	24	these	these	DT
cord-290566-tmsocyfc	52	25	cells	cell	NNS
cord-290566-tmsocyfc	52	26	diVerentiate	diVerentiate	NNP
cord-290566-tmsocyfc	52	27	into	into	IN
cord-290566-tmsocyfc	52	28	Th17	th17	CD
cord-290566-tmsocyfc	52	29	cells	cell	NNS
cord-290566-tmsocyfc	52	30	(	(	-LRB-
cord-290566-tmsocyfc	52	31	Bettelli	Bettelli	NNP
cord-290566-tmsocyfc	52	32	et	et	FW
cord-290566-tmsocyfc	52	33	al	al	NNP
cord-290566-tmsocyfc	52	34	.	.	NNP
cord-290566-tmsocyfc	52	35	,	,	,
cord-290566-tmsocyfc	52	36	2006	2006	CD
cord-290566-tmsocyfc	52	37	)	)	-RRB-
cord-290566-tmsocyfc	52	38	.	.	.
cord-290566-tmsocyfc	53	1	TANUJA	TANUJA	NNP
cord-290566-tmsocyfc	53	2	CHITNIS	CHITNIS	NNP
cord-290566-tmsocyfc	54	1	Traditionally	traditionally	RB
cord-290566-tmsocyfc	54	2	,	,	,
cord-290566-tmsocyfc	54	3	Th	Th	NNP
cord-290566-tmsocyfc	54	4	cell	cell	NN
cord-290566-tmsocyfc	54	5	subsets	subset	NNS
cord-290566-tmsocyfc	54	6	have	have	VBP
cord-290566-tmsocyfc	54	7	been	be	VBN
cord-290566-tmsocyfc	54	8	distinguished	distinguish	VBN
cord-290566-tmsocyfc	54	9	by	by	IN
cord-290566-tmsocyfc	54	10	their	-PRON-	PRP$
cord-290566-tmsocyfc	54	11	patterns	pattern	NNS
cord-290566-tmsocyfc	54	12	of	of	IN
cord-290566-tmsocyfc	54	13	cytokine	cytokine	NN
cord-290566-tmsocyfc	54	14	production	production	NN
cord-290566-tmsocyfc	54	15	,	,	,
cord-290566-tmsocyfc	54	16	however	however	RB
cord-290566-tmsocyfc	54	17	identification	identification	NN
cord-290566-tmsocyfc	54	18	of	of	IN
cord-290566-tmsocyfc	54	19	distinguishing	distinguish	VBG
cord-290566-tmsocyfc	54	20	surface	surface	NN
cord-290566-tmsocyfc	54	21	molecule	molecule	NN
cord-290566-tmsocyfc	54	22	markers	marker	NNS
cord-290566-tmsocyfc	54	23	has	have	VBZ
cord-290566-tmsocyfc	54	24	been	be	VBN
cord-290566-tmsocyfc	54	25	a	a	DT
cord-290566-tmsocyfc	54	26	major	major	JJ
cord-290566-tmsocyfc	54	27	advance	advance	NN
cord-290566-tmsocyfc	54	28	in	in	IN
cord-290566-tmsocyfc	54	29	the	the	DT
cord-290566-tmsocyfc	54	30	field	field	NN
cord-290566-tmsocyfc	54	31	.	.	.
cord-290566-tmsocyfc	55	1	T	t	NN
cord-290566-tmsocyfc	55	2	-	-	HYPH
cord-290566-tmsocyfc	55	3	cell-	cell-	NN
cord-290566-tmsocyfc	55	4	,	,	,
cord-290566-tmsocyfc	55	5	Ig-	ig-	UH
cord-290566-tmsocyfc	55	6	,	,	,
cord-290566-tmsocyfc	55	7	and	and	CC
cord-290566-tmsocyfc	55	8	mucin	mucin	NN
cord-290566-tmsocyfc	55	9	-	-	HYPH
cord-290566-tmsocyfc	55	10	domaincontaining	domaincontaine	VBG
cord-290566-tmsocyfc	55	11	molecules	molecule	NNS
cord-290566-tmsocyfc	56	1	(	(	-LRB-
cord-290566-tmsocyfc	56	2	Tim	Tim	NNP
cord-290566-tmsocyfc	56	3	)	)	-RRB-
cord-290566-tmsocyfc	56	4	represent	represent	VB
cord-290566-tmsocyfc	56	5	an	an	DT
cord-290566-tmsocyfc	56	6	important	important	JJ
cord-290566-tmsocyfc	56	7	family	family	NN
cord-290566-tmsocyfc	56	8	of	of	IN
cord-290566-tmsocyfc	56	9	molecules	molecule	NNS
cord-290566-tmsocyfc	56	10	which	which	WDT
cord-290566-tmsocyfc	56	11	encode	encode	VBP
cord-290566-tmsocyfc	56	12	cell	cell	NN
cord-290566-tmsocyfc	56	13	-	-	HYPH
cord-290566-tmsocyfc	56	14	surface	surface	NN
cord-290566-tmsocyfc	56	15	receptors	receptor	NNS
cord-290566-tmsocyfc	56	16	involved	involve	VBN
cord-290566-tmsocyfc	56	17	in	in	IN
cord-290566-tmsocyfc	56	18	the	the	DT
cord-290566-tmsocyfc	56	19	regulation	regulation	NN
cord-290566-tmsocyfc	56	20	of	of	IN
cord-290566-tmsocyfc	56	21	Th1-and	th1-and	NN
cord-290566-tmsocyfc	56	22	Th2-cellmediated	Th2-cellmediated	NNP
cord-290566-tmsocyfc	56	23	immunity	immunity	NN
cord-290566-tmsocyfc	56	24	.	.	.
cord-290566-tmsocyfc	57	1	Tim-3	Tim-3	NNP
cord-290566-tmsocyfc	57	2	is	be	VBZ
cord-290566-tmsocyfc	57	3	specifically	specifically	RB
cord-290566-tmsocyfc	57	4	expressed	express	VBN
cord-290566-tmsocyfc	57	5	on	on	IN
cord-290566-tmsocyfc	57	6	Th1	th1	NN
cord-290566-tmsocyfc	57	7	cells	cell	NNS
cord-290566-tmsocyfc	57	8	and	and	CC
cord-290566-tmsocyfc	57	9	negatively	negatively	RB
cord-290566-tmsocyfc	57	10	regulates	regulate	VBZ
cord-290566-tmsocyfc	57	11	Th1	th1	NN
cord-290566-tmsocyfc	57	12	responses	response	NNS
cord-290566-tmsocyfc	57	13	through	through	IN
cord-290566-tmsocyfc	57	14	interaction	interaction	NN
cord-290566-tmsocyfc	57	15	with	with	IN
cord-290566-tmsocyfc	57	16	the	the	DT
cord-290566-tmsocyfc	57	17	Tim-3	Tim-3	NNP
cord-290566-tmsocyfc	57	18	ligand	ligand	NN
cord-290566-tmsocyfc	57	19	,	,	,
cord-290566-tmsocyfc	57	20	galactin-9	galactin-9	NNP
cord-290566-tmsocyfc	57	21	,	,	,
cord-290566-tmsocyfc	57	22	also	also	RB
cord-290566-tmsocyfc	57	23	expressed	express	VBD
cord-290566-tmsocyfc	57	24	on	on	IN
cord-290566-tmsocyfc	57	25	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	57	26	T	T	NNP
cord-290566-tmsocyfc	57	27	cells	cell	NNS
cord-290566-tmsocyfc	57	28	(	(	-LRB-
cord-290566-tmsocyfc	57	29	Monney	Monney	NNP
cord-290566-tmsocyfc	57	30	et	et	NNP
cord-290566-tmsocyfc	57	31	al	al	NNP
cord-290566-tmsocyfc	57	32	.	.	NNP
cord-290566-tmsocyfc	57	33	,	,	,
cord-290566-tmsocyfc	57	34	2002	2002	CD
cord-290566-tmsocyfc	57	35	;	;	:
cord-290566-tmsocyfc	57	36	Sabatos	Sabatos	NNP
cord-290566-tmsocyfc	57	37	et	et	NNP
cord-290566-tmsocyfc	57	38	al	al	NNP
cord-290566-tmsocyfc	57	39	.	.	NNP
cord-290566-tmsocyfc	57	40	,	,	,
cord-290566-tmsocyfc	57	41	2003	2003	CD
cord-290566-tmsocyfc	57	42	;	;	:
cord-290566-tmsocyfc	57	43	Zhu	Zhu	NNP
cord-290566-tmsocyfc	57	44	et	et	FW
cord-290566-tmsocyfc	57	45	al	al	NNP
cord-290566-tmsocyfc	57	46	.	.	NNP
cord-290566-tmsocyfc	57	47	,	,	,
cord-290566-tmsocyfc	57	48	2005	2005	CD
cord-290566-tmsocyfc	57	49	)	)	-RRB-
cord-290566-tmsocyfc	57	50	.	.	.
cord-290566-tmsocyfc	58	1	Tim-2	Tim-2	NNP
cord-290566-tmsocyfc	58	2	is	be	VBZ
cord-290566-tmsocyfc	58	3	expressed	express	VBN
cord-290566-tmsocyfc	58	4	on	on	IN
cord-290566-tmsocyfc	58	5	Th2	Th2	NNP
cord-290566-tmsocyfc	58	6	cells	cell	NNS
cord-290566-tmsocyfc	58	7	and	and	CC
cord-290566-tmsocyfc	58	8	appears	appear	VBZ
cord-290566-tmsocyfc	58	9	to	to	TO
cord-290566-tmsocyfc	58	10	negatively	negatively	RB
cord-290566-tmsocyfc	58	11	regulate	regulate	VB
cord-290566-tmsocyfc	58	12	Th2	th2	CD
cord-290566-tmsocyfc	58	13	cell	cell	NN
cord-290566-tmsocyfc	58	14	proliferation	proliferation	NN
cord-290566-tmsocyfc	58	15	,	,	,
cord-290566-tmsocyfc	58	16	although	although	IN
cord-290566-tmsocyfc	58	17	this	this	DT
cord-290566-tmsocyfc	58	18	has	have	VBZ
cord-290566-tmsocyfc	58	19	not	not	RB
cord-290566-tmsocyfc	58	20	been	be	VBN
cord-290566-tmsocyfc	58	21	fully	fully	RB
cord-290566-tmsocyfc	58	22	established	establish	VBN
cord-290566-tmsocyfc	58	23	.	.	.
cord-290566-tmsocyfc	59	1	Tim-1	Tim-1	NNP
cord-290566-tmsocyfc	59	2	is	be	VBZ
cord-290566-tmsocyfc	59	3	expressed	express	VBN
cord-290566-tmsocyfc	59	4	on	on	IN
cord-290566-tmsocyfc	59	5	Th2	Th2	NNP
cord-290566-tmsocyfc	59	6	cells	cell	NNS
cord-290566-tmsocyfc	59	7	>	>	IN
cord-290566-tmsocyfc	59	8	Th1	th1	NN
cord-290566-tmsocyfc	59	9	cells	cell	NNS
cord-290566-tmsocyfc	59	10	and	and	CC
cord-290566-tmsocyfc	59	11	interacts	interact	VBZ
cord-290566-tmsocyfc	59	12	with	with	IN
cord-290566-tmsocyfc	59	13	Tim-4	Tim-4	NNP
cord-290566-tmsocyfc	59	14	on	on	IN
cord-290566-tmsocyfc	59	15	APCs	apc	NNS
cord-290566-tmsocyfc	59	16	to	to	TO
cord-290566-tmsocyfc	59	17	induce	induce	VB
cord-290566-tmsocyfc	59	18	T	t	NN
cord-290566-tmsocyfc	59	19	-	-	HYPH
cord-290566-tmsocyfc	59	20	cell	cell	NN
cord-290566-tmsocyfc	59	21	proliferation	proliferation	NN
cord-290566-tmsocyfc	59	22	(	(	-LRB-
cord-290566-tmsocyfc	59	23	Meyers	Meyers	NNP
cord-290566-tmsocyfc	59	24	et	et	NNP
cord-290566-tmsocyfc	59	25	al	al	NNP
cord-290566-tmsocyfc	59	26	.	.	NNP
cord-290566-tmsocyfc	59	27	,	,	,
cord-290566-tmsocyfc	59	28	2005	2005	CD
cord-290566-tmsocyfc	59	29	)	)	-RRB-
cord-290566-tmsocyfc	59	30	.	.	.
cord-290566-tmsocyfc	60	1	Intracellular	Intracellular	NNP
cord-290566-tmsocyfc	60	2	signaling	signal	VBG
cord-290566-tmsocyfc	60	3	mechanisms	mechanism	NNS
cord-290566-tmsocyfc	60	4	provide	provide	VBP
cord-290566-tmsocyfc	60	5	the	the	DT
cord-290566-tmsocyfc	60	6	link	link	NN
cord-290566-tmsocyfc	60	7	between	between	IN
cord-290566-tmsocyfc	60	8	the	the	DT
cord-290566-tmsocyfc	60	9	binding	binding	NN
cord-290566-tmsocyfc	60	10	of	of	IN
cord-290566-tmsocyfc	60	11	the	the	DT
cord-290566-tmsocyfc	60	12	cytokine	cytokine	NN
cord-290566-tmsocyfc	60	13	with	with	IN
cord-290566-tmsocyfc	60	14	its	-PRON-	PRP$
cord-290566-tmsocyfc	60	15	receptor	receptor	NN
cord-290566-tmsocyfc	60	16	and	and	CC
cord-290566-tmsocyfc	60	17	the	the	DT
cord-290566-tmsocyfc	60	18	eVect	eVect	NNP
cord-290566-tmsocyfc	60	19	of	of	IN
cord-290566-tmsocyfc	60	20	the	the	DT
cord-290566-tmsocyfc	60	21	cytokine	cytokine	NN
cord-290566-tmsocyfc	60	22	on	on	IN
cord-290566-tmsocyfc	60	23	cellular	cellular	JJ
cord-290566-tmsocyfc	60	24	function	function	NN
cord-290566-tmsocyfc	60	25	.	.	.
cord-290566-tmsocyfc	61	1	The	the	DT
cord-290566-tmsocyfc	61	2	Janus	Janus	NNP
cord-290566-tmsocyfc	61	3	kinase	kinase	NN
cord-290566-tmsocyfc	61	4	and	and	CC
cord-290566-tmsocyfc	61	5	signal	signal	NN
cord-290566-tmsocyfc	61	6	transducer	transducer	NN
cord-290566-tmsocyfc	61	7	and	and	CC
cord-290566-tmsocyfc	61	8	activator	activator	NN
cord-290566-tmsocyfc	61	9	of	of	IN
cord-290566-tmsocyfc	61	10	transcription	transcription	NN
cord-290566-tmsocyfc	61	11	(	(	-LRB-
cord-290566-tmsocyfc	61	12	Jak	Jak	NNP
cord-290566-tmsocyfc	61	13	/	/	SYM
cord-290566-tmsocyfc	61	14	STAT	STAT	NNP
cord-290566-tmsocyfc	61	15	)	)	-RRB-
cord-290566-tmsocyfc	61	16	family	family	NN
cord-290566-tmsocyfc	61	17	of	of	IN
cord-290566-tmsocyfc	61	18	transducer	transducer	NN
cord-290566-tmsocyfc	61	19	/	/	SYM
cord-290566-tmsocyfc	61	20	transcription	transcription	NN
cord-290566-tmsocyfc	61	21	-	-	HYPH
cord-290566-tmsocyfc	61	22	activating	activate	VBG
cord-290566-tmsocyfc	61	23	factors	factor	NNS
cord-290566-tmsocyfc	61	24	plays	play	VBZ
cord-290566-tmsocyfc	61	25	a	a	DT
cord-290566-tmsocyfc	61	26	critical	critical	JJ
cord-290566-tmsocyfc	61	27	role	role	NN
cord-290566-tmsocyfc	61	28	in	in	IN
cord-290566-tmsocyfc	61	29	the	the	DT
cord-290566-tmsocyfc	61	30	signaling	signaling	NN
cord-290566-tmsocyfc	61	31	of	of	IN
cord-290566-tmsocyfc	61	32	many	many	JJ
cord-290566-tmsocyfc	61	33	cytokine	cytokine	JJ
cord-290566-tmsocyfc	61	34	receptors	receptor	NNS
cord-290566-tmsocyfc	61	35	.	.	.
cord-290566-tmsocyfc	62	1	Cytokine	cytokine	NN
cord-290566-tmsocyfc	62	2	binding	binding	NN
cord-290566-tmsocyfc	62	3	to	to	IN
cord-290566-tmsocyfc	62	4	the	the	DT
cord-290566-tmsocyfc	62	5	specific	specific	JJ
cord-290566-tmsocyfc	62	6	receptor	receptor	NN
cord-290566-tmsocyfc	62	7	activates	activate	VBZ
cord-290566-tmsocyfc	62	8	the	the	DT
cord-290566-tmsocyfc	62	9	Jak	Jak	NNP
cord-290566-tmsocyfc	62	10	molecule	molecule	NN
cord-290566-tmsocyfc	62	11	associated	associate	VBN
cord-290566-tmsocyfc	62	12	with	with	IN
cord-290566-tmsocyfc	62	13	the	the	DT
cord-290566-tmsocyfc	62	14	receptor	receptor	NN
cord-290566-tmsocyfc	62	15	,	,	,
cord-290566-tmsocyfc	62	16	causing	cause	VBG
cord-290566-tmsocyfc	62	17	phosphorylation	phosphorylation	NN
cord-290566-tmsocyfc	62	18	of	of	IN
cord-290566-tmsocyfc	62	19	tyrosine	tyrosine	NN
cord-290566-tmsocyfc	62	20	residues	residue	NNS
cord-290566-tmsocyfc	62	21	,	,	,
cord-290566-tmsocyfc	62	22	and	and	CC
cord-290566-tmsocyfc	62	23	binding	binding	NN
cord-290566-tmsocyfc	62	24	of	of	IN
cord-290566-tmsocyfc	62	25	the	the	DT
cord-290566-tmsocyfc	62	26	Jak	Jak	NNP
cord-290566-tmsocyfc	62	27	molecules	molecule	NNS
cord-290566-tmsocyfc	62	28	to	to	IN
cord-290566-tmsocyfc	62	29	its	-PRON-	PRP$
cord-290566-tmsocyfc	62	30	receptor	receptor	NN
cord-290566-tmsocyfc	62	31	.	.	.
cord-290566-tmsocyfc	63	1	This	this	DT
cord-290566-tmsocyfc	63	2	facilitates	facilitate	VBZ
cord-290566-tmsocyfc	63	3	binding	binding	NN
cord-290566-tmsocyfc	63	4	of	of	IN
cord-290566-tmsocyfc	63	5	STAT	stat	NN
cord-290566-tmsocyfc	63	6	proteins	protein	NNS
cord-290566-tmsocyfc	63	7	to	to	IN
cord-290566-tmsocyfc	63	8	the	the	DT
cord-290566-tmsocyfc	63	9	phosphorylated	phosphorylated	JJ
cord-290566-tmsocyfc	63	10	receptor	receptor	NN
cord-290566-tmsocyfc	63	11	,	,	,
cord-290566-tmsocyfc	63	12	which	which	WDT
cord-290566-tmsocyfc	63	13	subsequently	subsequently	RB
cord-290566-tmsocyfc	63	14	dissociates	dissociate	VBZ
cord-290566-tmsocyfc	63	15	from	from	IN
cord-290566-tmsocyfc	63	16	the	the	DT
cord-290566-tmsocyfc	63	17	receptor	receptor	NN
cord-290566-tmsocyfc	63	18	,	,	,
cord-290566-tmsocyfc	63	19	dimerizes	dimerize	NNS
cord-290566-tmsocyfc	63	20	,	,	,
cord-290566-tmsocyfc	63	21	and	and	CC
cord-290566-tmsocyfc	63	22	activates	activate	VBZ
cord-290566-tmsocyfc	63	23	transcription	transcription	NN
cord-290566-tmsocyfc	63	24	of	of	IN
cord-290566-tmsocyfc	63	25	genes	gene	NNS
cord-290566-tmsocyfc	63	26	containing	contain	VBG
cord-290566-tmsocyfc	63	27	specific	specific	JJ
cord-290566-tmsocyfc	63	28	cis	cis	JJ
cord-290566-tmsocyfc	63	29	-	-	HYPH
cord-290566-tmsocyfc	63	30	regulatory	regulatory	JJ
cord-290566-tmsocyfc	63	31	STAT	stat	NN
cord-290566-tmsocyfc	63	32	-	-	HYPH
cord-290566-tmsocyfc	63	33	binding	bind	VBG
cord-290566-tmsocyfc	63	34	sequences	sequence	NNS
cord-290566-tmsocyfc	63	35	.	.	.
cord-290566-tmsocyfc	64	1	DiVerent	DiVerent	NNP
cord-290566-tmsocyfc	64	2	cytokine	cytokine	NN
cord-290566-tmsocyfc	64	3	receptors	receptor	NNS
cord-290566-tmsocyfc	64	4	are	be	VBP
cord-290566-tmsocyfc	64	5	associated	associate	VBN
cord-290566-tmsocyfc	64	6	with	with	IN
cord-290566-tmsocyfc	64	7	diVerent	diVerent	NNP
cord-290566-tmsocyfc	64	8	Jak	Jak	NNP
cord-290566-tmsocyfc	64	9	/	/	SYM
cord-290566-tmsocyfc	64	10	STAT	stat	NN
cord-290566-tmsocyfc	64	11	proteins	protein	NNS
cord-290566-tmsocyfc	64	12	.	.	.
cord-290566-tmsocyfc	65	1	The	the	DT
cord-290566-tmsocyfc	65	2	IL-12	IL-12	NNP
cord-290566-tmsocyfc	65	3	receptor	receptor	NN
cord-290566-tmsocyfc	65	4	is	be	VBZ
cord-290566-tmsocyfc	65	5	associated	associate	VBN
cord-290566-tmsocyfc	65	6	with	with	IN
cord-290566-tmsocyfc	66	1	Jak-2	Jak-2	NNP
cord-290566-tmsocyfc	66	2	and	and	CC
cord-290566-tmsocyfc	66	3	STAT3	STAT3	NNP
cord-290566-tmsocyfc	66	4	and	and	CC
cord-290566-tmsocyfc	66	5	STAT4	STAT4	NNP
cord-290566-tmsocyfc	67	1	(	(	-LRB-
cord-290566-tmsocyfc	67	2	Jacobson	Jacobson	NNP
cord-290566-tmsocyfc	67	3	et	et	NNP
cord-290566-tmsocyfc	67	4	al	al	NNP
cord-290566-tmsocyfc	67	5	.	.	NNP
cord-290566-tmsocyfc	67	6	,	,	,
cord-290566-tmsocyfc	67	7	1995	1995	CD
cord-290566-tmsocyfc	67	8	)	)	-RRB-
cord-290566-tmsocyfc	67	9	.	.	.
cord-290566-tmsocyfc	68	1	The	the	DT
cord-290566-tmsocyfc	68	2	IL-4	IL-4	NNP
cord-290566-tmsocyfc	68	3	receptor	receptor	NN
cord-290566-tmsocyfc	68	4	is	be	VBZ
cord-290566-tmsocyfc	68	5	associated	associate	VBN
cord-290566-tmsocyfc	68	6	with	with	IN
cord-290566-tmsocyfc	68	7	Jak-1	Jak-1	NNP
cord-290566-tmsocyfc	68	8	-	-	HYPH
cord-290566-tmsocyfc	68	9	3	3	NNP
cord-290566-tmsocyfc	68	10	and	and	CC
cord-290566-tmsocyfc	68	11	STAT6	STAT6	NNP
cord-290566-tmsocyfc	68	12	(	(	-LRB-
cord-290566-tmsocyfc	68	13	Kaplan	Kaplan	NNP
cord-290566-tmsocyfc	68	14	et	et	NNP
cord-290566-tmsocyfc	68	15	al	al	NNP
cord-290566-tmsocyfc	68	16	.	.	NNP
cord-290566-tmsocyfc	68	17	,	,	,
cord-290566-tmsocyfc	68	18	1996	1996	CD
cord-290566-tmsocyfc	68	19	;	;	:
cord-290566-tmsocyfc	68	20	Takeda	Takeda	NNP
cord-290566-tmsocyfc	68	21	et	et	NNP
cord-290566-tmsocyfc	68	22	al	al	NNP
cord-290566-tmsocyfc	68	23	.	.	NNP
cord-290566-tmsocyfc	68	24	,	,	,
cord-290566-tmsocyfc	68	25	1996	1996	CD
cord-290566-tmsocyfc	68	26	)	)	-RRB-
cord-290566-tmsocyfc	69	1	(	(	-LRB-
cord-290566-tmsocyfc	69	2	Fig	Fig	NNP
cord-290566-tmsocyfc	69	3	.	.	NNP
cord-290566-tmsocyfc	69	4	1	1	CD
cord-290566-tmsocyfc	69	5	)	)	-RRB-
cord-290566-tmsocyfc	69	6	.	.	.
cord-290566-tmsocyfc	70	1	Mice	mouse	NNS
cord-290566-tmsocyfc	70	2	deficient	deficient	JJ
cord-290566-tmsocyfc	70	3	in	in	IN
cord-290566-tmsocyfc	70	4	STAT6	stat6	NN
cord-290566-tmsocyfc	70	5	display	display	VB
cord-290566-tmsocyfc	70	6	a	a	DT
cord-290566-tmsocyfc	70	7	reduction	reduction	NN
cord-290566-tmsocyfc	70	8	in	in	IN
cord-290566-tmsocyfc	70	9	Th2	th2	CD
cord-290566-tmsocyfc	70	10	cytokine	cytokine	NN
cord-290566-tmsocyfc	70	11	production	production	NN
cord-290566-tmsocyfc	70	12	,	,	,
cord-290566-tmsocyfc	70	13	decreased	decrease	VBD
cord-290566-tmsocyfc	70	14	IL-4-induced	il-4-induced	CD
cord-290566-tmsocyfc	70	15	B	b	NN
cord-290566-tmsocyfc	70	16	-	-	HYPH
cord-290566-tmsocyfc	70	17	cell	cell	NN
cord-290566-tmsocyfc	70	18	proliferation	proliferation	NN
cord-290566-tmsocyfc	70	19	and	and	CC
cord-290566-tmsocyfc	70	20	reduced	reduced	JJ
cord-290566-tmsocyfc	70	21	IgE	IgE	NNP
cord-290566-tmsocyfc	70	22	(	(	-LRB-
cord-290566-tmsocyfc	70	23	Kaplan	Kaplan	NNP
cord-290566-tmsocyfc	70	24	et	et	NNP
cord-290566-tmsocyfc	70	25	al	al	NNP
cord-290566-tmsocyfc	70	26	.	.	NNP
cord-290566-tmsocyfc	70	27	,	,	,
cord-290566-tmsocyfc	70	28	1996	1996	CD
cord-290566-tmsocyfc	70	29	;	;	:
cord-290566-tmsocyfc	70	30	Takeda	Takeda	NNP
cord-290566-tmsocyfc	70	31	et	et	NNP
cord-290566-tmsocyfc	70	32	al	al	NNP
cord-290566-tmsocyfc	70	33	.	.	NNP
cord-290566-tmsocyfc	70	34	,	,	,
cord-290566-tmsocyfc	70	35	1996	1996	CD
cord-290566-tmsocyfc	70	36	)	)	-RRB-
cord-290566-tmsocyfc	70	37	.	.	.
cord-290566-tmsocyfc	71	1	In	in	IN
cord-290566-tmsocyfc	71	2	contrast	contrast	NN
cord-290566-tmsocyfc	71	3	,	,	,
cord-290566-tmsocyfc	71	4	STAT4	STAT4	NNP
cord-290566-tmsocyfc	71	5	plays	play	VBZ
cord-290566-tmsocyfc	71	6	a	a	DT
cord-290566-tmsocyfc	71	7	pivotal	pivotal	JJ
cord-290566-tmsocyfc	71	8	role	role	NN
cord-290566-tmsocyfc	71	9	in	in	IN
cord-290566-tmsocyfc	71	10	Th1	th1	CD
cord-290566-tmsocyfc	71	11	immune	immune	JJ
cord-290566-tmsocyfc	71	12	responses	response	NNS
cord-290566-tmsocyfc	71	13	.	.	.
cord-290566-tmsocyfc	72	1	STAT4	STAT4	NNP
cord-290566-tmsocyfc	72	2	is	be	VBZ
cord-290566-tmsocyfc	72	3	activated	activate	VBN
cord-290566-tmsocyfc	72	4	after	after	IN
cord-290566-tmsocyfc	72	5	IL-12	IL-12	NNP
cord-290566-tmsocyfc	72	6	interacts	interact	VBZ
cord-290566-tmsocyfc	72	7	with	with	IN
cord-290566-tmsocyfc	72	8	the	the	DT
cord-290566-tmsocyfc	72	9	IL-12	IL-12	NNP
cord-290566-tmsocyfc	72	10	receptor	receptor	NN
cord-290566-tmsocyfc	72	11	,	,	,
cord-290566-tmsocyfc	72	12	inducing	induce	VBG
cord-290566-tmsocyfc	72	13	transcription	transcription	NN
cord-290566-tmsocyfc	72	14	of	of	IN
cord-290566-tmsocyfc	72	15	IFN-	IFN-	NNP
cord-290566-tmsocyfc	72	16	(	(	-LRB-
cord-290566-tmsocyfc	72	17	Jacobson	Jacobson	NNP
cord-290566-tmsocyfc	72	18	et	et	NNP
cord-290566-tmsocyfc	72	19	al	al	NNP
cord-290566-tmsocyfc	72	20	.	.	NNP
cord-290566-tmsocyfc	72	21	,	,	,
cord-290566-tmsocyfc	72	22	1995	1995	CD
cord-290566-tmsocyfc	72	23	)	)	-RRB-
cord-290566-tmsocyfc	72	24	.	.	.
cord-290566-tmsocyfc	73	1	Mice	mouse	NNS
cord-290566-tmsocyfc	73	2	deficient	deficient	JJ
cord-290566-tmsocyfc	73	3	in	in	IN
cord-290566-tmsocyfc	73	4	STAT4	stat4	NN
cord-290566-tmsocyfc	73	5	lack	lack	NN
cord-290566-tmsocyfc	73	6	IL-12-induced	IL-12-induced	NNP
cord-290566-tmsocyfc	73	7	IFN	IFN	NNP
cord-290566-tmsocyfc	73	8	-	-	HYPH
cord-290566-tmsocyfc	73	9	production	production	NN
cord-290566-tmsocyfc	73	10	and	and	CC
cord-290566-tmsocyfc	73	11	Th1	th1	NN
cord-290566-tmsocyfc	73	12	diVerentiation	diverentiation	NN
cord-290566-tmsocyfc	74	1	(	(	-LRB-
cord-290566-tmsocyfc	74	2	Kaplan	Kaplan	NNP
cord-290566-tmsocyfc	74	3	et	et	NNP
cord-290566-tmsocyfc	74	4	al	al	NNP
cord-290566-tmsocyfc	74	5	.	.	.
cord-290566-tmsocyfc	75	1	,	,	,
cord-290566-tmsocyfc	75	2	1996	1996	CD
cord-290566-tmsocyfc	75	3	;	;	:
cord-290566-tmsocyfc	75	4	Thierfelder	Thierfelder	NNP
cord-290566-tmsocyfc	75	5	et	et	NNP
cord-290566-tmsocyfc	75	6	al	al	NNP
cord-290566-tmsocyfc	75	7	.	.	NNP
cord-290566-tmsocyfc	75	8	,	,	,
cord-290566-tmsocyfc	75	9	1996	1996	CD
cord-290566-tmsocyfc	75	10	)	)	-RRB-
cord-290566-tmsocyfc	75	11	,	,	,
cord-290566-tmsocyfc	75	12	and	and	CC
cord-290566-tmsocyfc	75	13	display	display	VB
cord-290566-tmsocyfc	75	14	a	a	DT
cord-290566-tmsocyfc	75	15	predominantly	predominantly	RB
cord-290566-tmsocyfc	75	16	Th2	th2	CD
cord-290566-tmsocyfc	75	17	phenotype	phenotype	NN
cord-290566-tmsocyfc	75	18	(	(	-LRB-
cord-290566-tmsocyfc	75	19	Kaplan	Kaplan	NNP
cord-290566-tmsocyfc	75	20	et	et	NNP
cord-290566-tmsocyfc	75	21	al	al	NNP
cord-290566-tmsocyfc	75	22	.	.	NNP
cord-290566-tmsocyfc	75	23	,	,	,
cord-290566-tmsocyfc	75	24	1996	1996	CD
cord-290566-tmsocyfc	75	25	)	)	-RRB-
cord-290566-tmsocyfc	75	26	.	.	.
cord-290566-tmsocyfc	76	1	T	t	NN
cord-290566-tmsocyfc	76	2	-	-	HYPH
cord-290566-tmsocyfc	76	3	bet	bet	NN
cord-290566-tmsocyfc	76	4	is	be	VBZ
cord-290566-tmsocyfc	76	5	a	a	DT
cord-290566-tmsocyfc	76	6	Th1-specific	Th1-specific	NNP
cord-290566-tmsocyfc	76	7	T	T	NNP
cord-290566-tmsocyfc	76	8	box	box	NN
cord-290566-tmsocyfc	76	9	transcription	transcription	NN
cord-290566-tmsocyfc	76	10	factor	factor	NN
cord-290566-tmsocyfc	76	11	that	that	WDT
cord-290566-tmsocyfc	76	12	directly	directly	RB
cord-290566-tmsocyfc	76	13	controls	control	VBZ
cord-290566-tmsocyfc	76	14	the	the	DT
cord-290566-tmsocyfc	76	15	expression	expression	NN
cord-290566-tmsocyfc	76	16	of	of	IN
cord-290566-tmsocyfc	76	17	the	the	DT
cord-290566-tmsocyfc	76	18	hallmark	hallmark	JJ
cord-290566-tmsocyfc	76	19	Th1	th1	CD
cord-290566-tmsocyfc	76	20	cytokine	cytokine	NN
cord-290566-tmsocyfc	76	21	,	,	,
cord-290566-tmsocyfc	76	22	IFN-	IFN-	NNP
cord-290566-tmsocyfc	76	23	,	,	,
cord-290566-tmsocyfc	76	24	and	and	CC
cord-290566-tmsocyfc	76	25	IL-12R2	il-12r2	PRP$
cord-290566-tmsocyfc	76	26	expression	expression	NN
cord-290566-tmsocyfc	76	27	,	,	,
cord-290566-tmsocyfc	76	28	thus	thus	RB
cord-290566-tmsocyfc	76	29	facilitating	facilitate	VBG
cord-290566-tmsocyfc	76	30	Th1	th1	NN
cord-290566-tmsocyfc	76	31	cell	cell	NN
cord-290566-tmsocyfc	76	32	diVerentiation	diverentiation	NN
cord-290566-tmsocyfc	76	33	(	(	-LRB-
cord-290566-tmsocyfc	76	34	Szabo	Szabo	NNP
cord-290566-tmsocyfc	76	35	et	et	NNP
cord-290566-tmsocyfc	76	36	al	al	NNP
cord-290566-tmsocyfc	76	37	.	.	NNP
cord-290566-tmsocyfc	76	38	,	,	,
cord-290566-tmsocyfc	76	39	2000	2000	CD
cord-290566-tmsocyfc	76	40	)	)	-RRB-
cord-290566-tmsocyfc	76	41	.	.	.
cord-290566-tmsocyfc	77	1	The	the	DT
cord-290566-tmsocyfc	77	2	transcription	transcription	NN
cord-290566-tmsocyfc	77	3	factor	factor	NN
cord-290566-tmsocyfc	77	4	c	c	NN
cord-290566-tmsocyfc	77	5	-	-	HYPH
cord-290566-tmsocyfc	77	6	maf	maf	NNP
cord-290566-tmsocyfc	77	7	enhances	enhance	VBZ
cord-290566-tmsocyfc	77	8	IL-4	IL-4	NNP
cord-290566-tmsocyfc	77	9	production	production	NN
cord-290566-tmsocyfc	77	10	and	and	CC
cord-290566-tmsocyfc	77	11	represents	represent	VBZ
cord-290566-tmsocyfc	77	12	an	an	DT
cord-290566-tmsocyfc	77	13	important	important	JJ
cord-290566-tmsocyfc	77	14	step	step	NN
cord-290566-tmsocyfc	77	15	in	in	IN
cord-290566-tmsocyfc	77	16	the	the	DT
cord-290566-tmsocyfc	77	17	induction	induction	NN
cord-290566-tmsocyfc	77	18	of	of	IN
cord-290566-tmsocyfc	77	19	Th2	Th2	NNP
cord-290566-tmsocyfc	77	20	cells	cell	NNS
cord-290566-tmsocyfc	77	21	(	(	-LRB-
cord-290566-tmsocyfc	77	22	Ho	Ho	NNP
cord-290566-tmsocyfc	77	23	et	et	FW
cord-290566-tmsocyfc	77	24	al	al	NNP
cord-290566-tmsocyfc	77	25	.	.	NNP
cord-290566-tmsocyfc	77	26	,	,	,
cord-290566-tmsocyfc	77	27	1996	1996	CD
cord-290566-tmsocyfc	77	28	)	)	-RRB-
cord-290566-tmsocyfc	77	29	.	.	.
cord-290566-tmsocyfc	78	1	GATA-3	GATA-3	NNP
cord-290566-tmsocyfc	78	2	was	be	VBD
cord-290566-tmsocyfc	78	3	found	find	VBN
cord-290566-tmsocyfc	78	4	to	to	TO
cord-290566-tmsocyfc	78	5	be	be	VB
cord-290566-tmsocyfc	78	6	an	an	DT
cord-290566-tmsocyfc	78	7	STAT6-independent	STAT6-independent	NNP
cord-290566-tmsocyfc	78	8	inducer	inducer	NN
cord-290566-tmsocyfc	78	9	of	of	IN
cord-290566-tmsocyfc	78	10	Th2	th2	CD
cord-290566-tmsocyfc	78	11	diVerentiation	diVerentiation	NNP
cord-290566-tmsocyfc	78	12	,	,	,
cord-290566-tmsocyfc	78	13	and	and	CC
cord-290566-tmsocyfc	78	14	is	be	VBZ
cord-290566-tmsocyfc	78	15	located	locate	VBN
cord-290566-tmsocyfc	78	16	upstream	upstream	RB
cord-290566-tmsocyfc	78	17	of	of	IN
cord-290566-tmsocyfc	78	18	c	c	NN
cord-290566-tmsocyfc	78	19	-	-	HYPH
cord-290566-tmsocyfc	78	20	maf	maf	NNP
cord-290566-tmsocyfc	78	21	,	,	,
cord-290566-tmsocyfc	78	22	thus	thus	RB
cord-290566-tmsocyfc	78	23	representing	represent	VBG
cord-290566-tmsocyfc	78	24	a	a	DT
cord-290566-tmsocyfc	78	25	master	master	NN
cord-290566-tmsocyfc	78	26	switch	switch	NN
cord-290566-tmsocyfc	78	27	in	in	IN
cord-290566-tmsocyfc	78	28	Th2	th2	CD
cord-290566-tmsocyfc	78	29	development	development	NN
cord-290566-tmsocyfc	78	30	and	and	CC
cord-290566-tmsocyfc	78	31	commitment	commitment	NN
cord-290566-tmsocyfc	79	1	(	(	-LRB-
cord-290566-tmsocyfc	79	2	Ouyang	Ouyang	NNP
cord-290566-tmsocyfc	79	3	et	et	NNP
cord-290566-tmsocyfc	79	4	al	al	NNP
cord-290566-tmsocyfc	79	5	.	.	NNP
cord-290566-tmsocyfc	79	6	,	,	,
cord-290566-tmsocyfc	79	7	2000	2000	CD
cord-290566-tmsocyfc	79	8	)	)	-RRB-
cord-290566-tmsocyfc	79	9	.	.	.
cord-290566-tmsocyfc	80	1	Th17	Th17	NNP
cord-290566-tmsocyfc	81	1	diVerentiation	diVerentiation	NNP
cord-290566-tmsocyfc	81	2	is	be	VBZ
cord-290566-tmsocyfc	81	3	independent	independent	JJ
cord-290566-tmsocyfc	81	4	of	of	IN
cord-290566-tmsocyfc	81	5	STAT4	STAT4	NNP
cord-290566-tmsocyfc	82	1	and	and	CC
cord-290566-tmsocyfc	82	2	STAT6	STAT6	NNS
cord-290566-tmsocyfc	82	3	signaling	signal	VBG
cord-290566-tmsocyfc	83	1	(	(	-LRB-
cord-290566-tmsocyfc	83	2	Park	Park	NNP
cord-290566-tmsocyfc	83	3	et	et	FW
cord-290566-tmsocyfc	83	4	al	al	NNP
cord-290566-tmsocyfc	83	5	.	.	NNP
cord-290566-tmsocyfc	83	6	,	,	,
cord-290566-tmsocyfc	83	7	2005	2005	CD
cord-290566-tmsocyfc	83	8	)	)	-RRB-
cord-290566-tmsocyfc	83	9	;	;	:
cord-290566-tmsocyfc	83	10	however	however	RB
cord-290566-tmsocyfc	83	11	,	,	,
cord-290566-tmsocyfc	83	12	it	-PRON-	PRP
cord-290566-tmsocyfc	83	13	has	have	VBZ
cord-290566-tmsocyfc	83	14	been	be	VBN
cord-290566-tmsocyfc	83	15	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	83	16	that	that	IN
cord-290566-tmsocyfc	83	17	STAT3	STAT3	NNP
cord-290566-tmsocyfc	83	18	signaling	signaling	NN
cord-290566-tmsocyfc	83	19	is	be	VBZ
cord-290566-tmsocyfc	83	20	activated	activate	VBN
cord-290566-tmsocyfc	83	21	by	by	IN
cord-290566-tmsocyfc	83	22	both	both	DT
cord-290566-tmsocyfc	83	23	IL-6	IL-6	NNP
cord-290566-tmsocyfc	83	24	and	and	CC
cord-290566-tmsocyfc	83	25	IL-23	IL-23	NNP
cord-290566-tmsocyfc	83	26	,	,	,
cord-290566-tmsocyfc	83	27	and	and	CC
cord-290566-tmsocyfc	83	28	binds	bind	VBZ
cord-290566-tmsocyfc	83	29	to	to	IN
cord-290566-tmsocyfc	83	30	IL-17	IL-17	NNP
cord-290566-tmsocyfc	83	31	gene	gene	NN
cord-290566-tmsocyfc	83	32	promoters	promoter	NNS
cord-290566-tmsocyfc	83	33	(	(	-LRB-
cord-290566-tmsocyfc	83	34	Chen	Chen	NNP
cord-290566-tmsocyfc	83	35	et	et	NNP
cord-290566-tmsocyfc	83	36	al	al	NNP
cord-290566-tmsocyfc	83	37	.	.	NNP
cord-290566-tmsocyfc	83	38	,	,	,
cord-290566-tmsocyfc	83	39	2006	2006	CD
cord-290566-tmsocyfc	83	40	)	)	-RRB-
cord-290566-tmsocyfc	83	41	.	.	.
cord-290566-tmsocyfc	84	1	SOCS-3	SOCS-3	NNP
cord-290566-tmsocyfc	84	2	is	be	VBZ
cord-290566-tmsocyfc	84	3	a	a	DT
cord-290566-tmsocyfc	84	4	major	major	JJ
cord-290566-tmsocyfc	84	5	regulator	regulator	NN
cord-290566-tmsocyfc	84	6	of	of	IN
cord-290566-tmsocyfc	84	7	IL-23-mediated	IL-23-mediated	NNP
cord-290566-tmsocyfc	84	8	STAT3	STAT3	NNP
cord-290566-tmsocyfc	84	9	phosphorylation	phosphorylation	NN
cord-290566-tmsocyfc	84	10	and	and	CC
cord-290566-tmsocyfc	84	11	subsequent	subsequent	JJ
cord-290566-tmsocyfc	84	12	Th17	th17	CD
cord-290566-tmsocyfc	84	13	generation	generation	NN
cord-290566-tmsocyfc	85	1	(	(	-LRB-
cord-290566-tmsocyfc	85	2	Chen	Chen	NNP
cord-290566-tmsocyfc	85	3	et	et	NNP
cord-290566-tmsocyfc	85	4	al	al	NNP
cord-290566-tmsocyfc	85	5	.	.	NNP
cord-290566-tmsocyfc	85	6	,	,	,
cord-290566-tmsocyfc	85	7	2006	2006	CD
cord-290566-tmsocyfc	85	8	)	)	-RRB-
cord-290566-tmsocyfc	85	9	.	.	.
cord-290566-tmsocyfc	86	1	Several	several	JJ
cord-290566-tmsocyfc	86	2	populations	population	NNS
cord-290566-tmsocyfc	86	3	of	of	IN
cord-290566-tmsocyfc	86	4	regulatory	regulatory	JJ
cord-290566-tmsocyfc	86	5	or	or	CC
cord-290566-tmsocyfc	86	6	suppressor	suppressor	NN
cord-290566-tmsocyfc	86	7	T	t	NN
cord-290566-tmsocyfc	86	8	cells	cell	NNS
cord-290566-tmsocyfc	86	9	have	have	VBP
cord-290566-tmsocyfc	86	10	been	be	VBN
cord-290566-tmsocyfc	86	11	described	describe	VBN
cord-290566-tmsocyfc	86	12	in	in	IN
cord-290566-tmsocyfc	86	13	humans	human	NNS
cord-290566-tmsocyfc	86	14	.	.	.
cord-290566-tmsocyfc	87	1	These	these	DT
cord-290566-tmsocyfc	87	2	include	include	VBP
cord-290566-tmsocyfc	87	3	CD4þCD25þFoxp3	CD4þCD25þFoxp3	NNP
cord-290566-tmsocyfc	87	4	regulatory	regulatory	JJ
cord-290566-tmsocyfc	87	5	T	t	NN
cord-290566-tmsocyfc	87	6	cells	cell	NNS
cord-290566-tmsocyfc	87	7	(	(	-LRB-
cord-290566-tmsocyfc	87	8	Baecher	Baecher	NNP
cord-290566-tmsocyfc	87	9	-	-	HYPH
cord-290566-tmsocyfc	87	10	Allan	Allan	NNP
cord-290566-tmsocyfc	87	11	et	et	NNP
cord-290566-tmsocyfc	87	12	al	al	NNP
cord-290566-tmsocyfc	87	13	.	.	NNP
cord-290566-tmsocyfc	87	14	,	,	,
cord-290566-tmsocyfc	87	15	2001	2001	CD
cord-290566-tmsocyfc	87	16	;	;	:
cord-290566-tmsocyfc	87	17	Dieckmann	Dieckmann	NNP
cord-290566-tmsocyfc	87	18	et	et	NNP
cord-290566-tmsocyfc	87	19	al	al	NNP
cord-290566-tmsocyfc	87	20	.	.	NNP
cord-290566-tmsocyfc	87	21	,	,	,
cord-290566-tmsocyfc	87	22	2001	2001	CD
cord-290566-tmsocyfc	87	23	;	;	:
cord-290566-tmsocyfc	87	24	Levings	Levings	NNP
cord-290566-tmsocyfc	87	25	et	et	NNP
cord-290566-tmsocyfc	87	26	al	al	NNP
cord-290566-tmsocyfc	87	27	.	.	NNP
cord-290566-tmsocyfc	87	28	,	,	,
cord-290566-tmsocyfc	87	29	2001	2001	CD
cord-290566-tmsocyfc	87	30	;	;	:
cord-290566-tmsocyfc	87	31	Stephens	Stephens	NNP
cord-290566-tmsocyfc	87	32	et	et	NNP
cord-290566-tmsocyfc	87	33	al	al	NNP
cord-290566-tmsocyfc	87	34	.	.	NNP
cord-290566-tmsocyfc	87	35	,	,	,
cord-290566-tmsocyfc	87	36	2001	2001	CD
cord-290566-tmsocyfc	87	37	;	;	:
cord-290566-tmsocyfc	87	38	Yagi	Yagi	NNP
cord-290566-tmsocyfc	87	39	et	et	FW
cord-290566-tmsocyfc	87	40	al	al	NNP
cord-290566-tmsocyfc	87	41	.	.	NNP
cord-290566-tmsocyfc	87	42	,	,	,
cord-290566-tmsocyfc	87	43	2004	2004	CD
cord-290566-tmsocyfc	87	44	)	)	-RRB-
cord-290566-tmsocyfc	87	45	,	,	,
cord-290566-tmsocyfc	87	46	CD8þCD28À	cd8þcd28à	RB
cord-290566-tmsocyfc	87	47	T	t	NN
cord-290566-tmsocyfc	87	48	cells	cell	NNS
cord-290566-tmsocyfc	87	49	(	(	-LRB-
cord-290566-tmsocyfc	87	50	Koide	Koide	NNP
cord-290566-tmsocyfc	87	51	and	and	CC
cord-290566-tmsocyfc	87	52	Engleman	Engleman	NNP
cord-290566-tmsocyfc	87	53	,	,	,
cord-290566-tmsocyfc	87	54	1990	1990	CD
cord-290566-tmsocyfc	87	55	)	)	-RRB-
cord-290566-tmsocyfc	87	56	,	,	.
cord-290566-tmsocyfc	88	1	IL-10producing	il-10producing	NN
cord-290566-tmsocyfc	88	2	Th2	th2	CD
cord-290566-tmsocyfc	88	3	cells	cell	NNS
cord-290566-tmsocyfc	88	4	(	(	-LRB-
cord-290566-tmsocyfc	88	5	Bacchetta	Bacchetta	NNP
cord-290566-tmsocyfc	88	6	et	et	NNP
cord-290566-tmsocyfc	88	7	al	al	NNP
cord-290566-tmsocyfc	88	8	.	.	NNP
cord-290566-tmsocyfc	88	9	,	,	,
cord-290566-tmsocyfc	88	10	1994	1994	CD
cord-290566-tmsocyfc	88	11	)	)	-RRB-
cord-290566-tmsocyfc	88	12	,	,	,
cord-290566-tmsocyfc	88	13	and	and	CC
cord-290566-tmsocyfc	88	14	TGF	TGF	NNP
cord-290566-tmsocyfc	88	15	--	--	:
cord-290566-tmsocyfc	88	16	producing	produce	VBG
cord-290566-tmsocyfc	88	17	Th3	th3	NN
cord-290566-tmsocyfc	88	18	cells	cell	NNS
cord-290566-tmsocyfc	88	19	(	(	-LRB-
cord-290566-tmsocyfc	88	20	Kitani	Kitani	NNP
cord-290566-tmsocyfc	88	21	et	et	NNP
cord-290566-tmsocyfc	88	22	al	al	NNP
cord-290566-tmsocyfc	88	23	.	.	NNP
cord-290566-tmsocyfc	88	24	,	,	,
cord-290566-tmsocyfc	88	25	2000	2000	CD
cord-290566-tmsocyfc	88	26	;	;	:
cord-290566-tmsocyfc	89	1	Roncarolo	Roncarolo	NNP
cord-290566-tmsocyfc	89	2	and	and	CC
cord-290566-tmsocyfc	89	3	Levings	Levings	NNP
cord-290566-tmsocyfc	89	4	,	,	,
cord-290566-tmsocyfc	89	5	2000	2000	CD
cord-290566-tmsocyfc	89	6	)	)	-RRB-
cord-290566-tmsocyfc	89	7	.	.	.
cord-290566-tmsocyfc	90	1	Regulatory	regulatory	JJ
cord-290566-tmsocyfc	90	2	T	t	NN
cord-290566-tmsocyfc	90	3	cells	cell	NNS
cord-290566-tmsocyfc	90	4	suppress	suppress	VBP
cord-290566-tmsocyfc	90	5	T	t	NN
cord-290566-tmsocyfc	90	6	-	-	HYPH
cord-290566-tmsocyfc	90	7	cell	cell	NN
cord-290566-tmsocyfc	90	8	proliferation	proliferation	NN
cord-290566-tmsocyfc	90	9	through	through	IN
cord-290566-tmsocyfc	90	10	a	a	DT
cord-290566-tmsocyfc	90	11	variety	variety	NN
cord-290566-tmsocyfc	90	12	of	of	IN
cord-290566-tmsocyfc	90	13	mechanisms	mechanism	NNS
cord-290566-tmsocyfc	90	14	,	,	,
cord-290566-tmsocyfc	90	15	including	include	VBG
cord-290566-tmsocyfc	90	16	the	the	DT
cord-290566-tmsocyfc	90	17	production	production	NN
cord-290566-tmsocyfc	90	18	of	of	IN
cord-290566-tmsocyfc	90	19	immunosuppressive	immunosuppressive	JJ
cord-290566-tmsocyfc	90	20	cytokines	cytokine	NNS
cord-290566-tmsocyfc	90	21	,	,	,
cord-290566-tmsocyfc	90	22	or	or	CC
cord-290566-tmsocyfc	90	23	through	through	IN
cord-290566-tmsocyfc	90	24	T	T	NNP
cord-290566-tmsocyfc	90	25	-	-	HYPH
cord-290566-tmsocyfc	90	26	T	t	NN
cord-290566-tmsocyfc	90	27	-	-	HYPH
cord-290566-tmsocyfc	90	28	cell	cell	NN
cord-290566-tmsocyfc	90	29	interactions	interaction	NNS
cord-290566-tmsocyfc	90	30	.	.	.
cord-290566-tmsocyfc	91	1	Several	several	JJ
cord-290566-tmsocyfc	91	2	studies	study	NNS
cord-290566-tmsocyfc	91	3	have	have	VBP
cord-290566-tmsocyfc	91	4	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	91	5	that	that	IN
cord-290566-tmsocyfc	91	6	these	these	DT
cord-290566-tmsocyfc	91	7	cells	cell	NNS
cord-290566-tmsocyfc	91	8	play	play	VBP
cord-290566-tmsocyfc	91	9	an	an	DT
cord-290566-tmsocyfc	91	10	important	important	JJ
cord-290566-tmsocyfc	91	11	role	role	NN
cord-290566-tmsocyfc	91	12	in	in	IN
cord-290566-tmsocyfc	91	13	the	the	DT
cord-290566-tmsocyfc	91	14	control	control	NN
cord-290566-tmsocyfc	91	15	of	of	IN
cord-290566-tmsocyfc	91	16	the	the	DT
cord-290566-tmsocyfc	91	17	immune	immune	JJ
cord-290566-tmsocyfc	91	18	48	48	CD
cord-290566-tmsocyfc	91	19	TANUJA	TANUJA	NNP
cord-290566-tmsocyfc	91	20	CHITNIS	CHITNIS	NNP
cord-290566-tmsocyfc	91	21	response	response	NN
cord-290566-tmsocyfc	91	22	in	in	IN
cord-290566-tmsocyfc	91	23	multiple	multiple	JJ
cord-290566-tmsocyfc	91	24	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	91	25	(	(	-LRB-
cord-290566-tmsocyfc	91	26	MS	MS	NNP
cord-290566-tmsocyfc	91	27	)	)	-RRB-
cord-290566-tmsocyfc	91	28	and	and	CC
cord-290566-tmsocyfc	91	29	that	that	IN
cord-290566-tmsocyfc	91	30	the	the	DT
cord-290566-tmsocyfc	91	31	function	function	NN
cord-290566-tmsocyfc	91	32	of	of	IN
cord-290566-tmsocyfc	91	33	regulatory	regulatory	JJ
cord-290566-tmsocyfc	91	34	T	t	NN
cord-290566-tmsocyfc	91	35	cells	cell	NNS
cord-290566-tmsocyfc	91	36	may	may	MD
cord-290566-tmsocyfc	91	37	be	be	VB
cord-290566-tmsocyfc	91	38	enhanced	enhance	VBN
cord-290566-tmsocyfc	91	39	by	by	IN
cord-290566-tmsocyfc	91	40	immunomodulatory	immunomodulatory	JJ
cord-290566-tmsocyfc	91	41	therapies	therapy	NNS
cord-290566-tmsocyfc	92	1	(	(	-LRB-
cord-290566-tmsocyfc	92	2	Crucian	Crucian	NNP
cord-290566-tmsocyfc	92	3	et	et	FW
cord-290566-tmsocyfc	92	4	al	al	NNP
cord-290566-tmsocyfc	92	5	.	.	.
cord-290566-tmsocyfc	93	1	,	,	,
cord-290566-tmsocyfc	93	2	1995	1995	CD
cord-290566-tmsocyfc	93	3	;	;	:
cord-290566-tmsocyfc	93	4	Fukaura	Fukaura	NNP
cord-290566-tmsocyfc	93	5	et	et	NNP
cord-290566-tmsocyfc	93	6	al	al	NNP
cord-290566-tmsocyfc	93	7	.	.	NNP
cord-290566-tmsocyfc	93	8	,	,	,
cord-290566-tmsocyfc	93	9	1996	1996	CD
cord-290566-tmsocyfc	93	10	;	;	:
cord-290566-tmsocyfc	93	11	Hafler	Hafler	NNP
cord-290566-tmsocyfc	93	12	et	et	NNP
cord-290566-tmsocyfc	93	13	al	al	NNP
cord-290566-tmsocyfc	93	14	.	.	NNP
cord-290566-tmsocyfc	93	15	,	,	,
cord-290566-tmsocyfc	93	16	1997	1997	CD
cord-290566-tmsocyfc	93	17	;	;	:
cord-290566-tmsocyfc	93	18	Karaszewski	Karaszewski	NNP
cord-290566-tmsocyfc	93	19	et	et	NNP
cord-290566-tmsocyfc	93	20	al	al	NNP
cord-290566-tmsocyfc	93	21	.	.	NNP
cord-290566-tmsocyfc	93	22	,	,	,
cord-290566-tmsocyfc	93	23	1991	1991	CD
cord-290566-tmsocyfc	93	24	;	;	:
cord-290566-tmsocyfc	93	25	Viglietta	Viglietta	NNP
cord-290566-tmsocyfc	93	26	et	et	NNP
cord-290566-tmsocyfc	93	27	al	al	NNP
cord-290566-tmsocyfc	93	28	.	.	NNP
cord-290566-tmsocyfc	93	29	,	,	,
cord-290566-tmsocyfc	93	30	2004	2004	CD
cord-290566-tmsocyfc	93	31	)	)	-RRB-
cord-290566-tmsocyfc	93	32	.	.	.
cord-290566-tmsocyfc	94	1	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	94	2	T	T	NNP
cord-290566-tmsocyfc	94	3	cells	cell	NNS
cord-290566-tmsocyfc	94	4	are	be	VBP
cord-290566-tmsocyfc	94	5	believed	believe	VBN
cord-290566-tmsocyfc	94	6	to	to	TO
cord-290566-tmsocyfc	94	7	play	play	VB
cord-290566-tmsocyfc	94	8	a	a	DT
cord-290566-tmsocyfc	94	9	central	central	JJ
cord-290566-tmsocyfc	94	10	role	role	NN
cord-290566-tmsocyfc	94	11	in	in	IN
cord-290566-tmsocyfc	94	12	the	the	DT
cord-290566-tmsocyfc	94	13	pathogenesis	pathogenesis	NN
cord-290566-tmsocyfc	94	14	of	of	IN
cord-290566-tmsocyfc	94	15	MS	MS	NNP
cord-290566-tmsocyfc	94	16	.	.	.
cord-290566-tmsocyfc	95	1	In	in	IN
cord-290566-tmsocyfc	95	2	this	this	DT
cord-290566-tmsocyfc	95	3	section	section	NN
cord-290566-tmsocyfc	95	4	,	,	,
cord-290566-tmsocyfc	95	5	we	-PRON-	PRP
cord-290566-tmsocyfc	95	6	summarize	summarize	VBP
cord-290566-tmsocyfc	95	7	the	the	DT
cord-290566-tmsocyfc	95	8	prevailing	prevail	VBG
cord-290566-tmsocyfc	95	9	theory	theory	NN
cord-290566-tmsocyfc	95	10	of	of	IN
cord-290566-tmsocyfc	95	11	the	the	DT
cord-290566-tmsocyfc	95	12	pathogenesis	pathogenesis	NN
cord-290566-tmsocyfc	95	13	of	of	IN
cord-290566-tmsocyfc	95	14	MS	MS	NNP
cord-290566-tmsocyfc	95	15	,	,	,
cord-290566-tmsocyfc	95	16	and	and	CC
cord-290566-tmsocyfc	95	17	evidence	evidence	NN
cord-290566-tmsocyfc	95	18	for	for	IN
cord-290566-tmsocyfc	95	19	the	the	DT
cord-290566-tmsocyfc	95	20	role	role	NN
cord-290566-tmsocyfc	95	21	of	of	IN
cord-290566-tmsocyfc	95	22	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	95	23	T	T	NNP
cord-290566-tmsocyfc	95	24	cells	cell	NNS
cord-290566-tmsocyfc	95	25	from	from	IN
cord-290566-tmsocyfc	95	26	both	both	DT
cord-290566-tmsocyfc	95	27	human	human	JJ
cord-290566-tmsocyfc	95	28	MS	MS	NNP
cord-290566-tmsocyfc	95	29	and	and	CC
cord-290566-tmsocyfc	95	30	animal	animal	NN
cord-290566-tmsocyfc	95	31	models	model	NNS
cord-290566-tmsocyfc	95	32	of	of	IN
cord-290566-tmsocyfc	95	33	disease	disease	NN
cord-290566-tmsocyfc	95	34	.	.	.
cord-290566-tmsocyfc	96	1	Much	much	JJ
cord-290566-tmsocyfc	96	2	of	of	IN
cord-290566-tmsocyfc	96	3	the	the	DT
cord-290566-tmsocyfc	96	4	current	current	JJ
cord-290566-tmsocyfc	96	5	understanding	understanding	NN
cord-290566-tmsocyfc	96	6	of	of	IN
cord-290566-tmsocyfc	96	7	the	the	DT
cord-290566-tmsocyfc	96	8	potential	potential	JJ
cord-290566-tmsocyfc	96	9	mechanistics	mechanistic	NNS
cord-290566-tmsocyfc	96	10	and	and	CC
cord-290566-tmsocyfc	96	11	role	role	NN
cord-290566-tmsocyfc	96	12	of	of	IN
cord-290566-tmsocyfc	96	13	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	96	14	T	T	NNP
cord-290566-tmsocyfc	96	15	cells	cell	NNS
cord-290566-tmsocyfc	96	16	in	in	IN
cord-290566-tmsocyfc	96	17	MS	MS	NNP
cord-290566-tmsocyfc	96	18	comes	come	VBZ
cord-290566-tmsocyfc	96	19	from	from	IN
cord-290566-tmsocyfc	96	20	the	the	DT
cord-290566-tmsocyfc	96	21	animal	animal	NN
cord-290566-tmsocyfc	96	22	models	model	NNS
cord-290566-tmsocyfc	96	23	simulating	simulate	VBG
cord-290566-tmsocyfc	96	24	features	feature	NNS
cord-290566-tmsocyfc	96	25	of	of	IN
cord-290566-tmsocyfc	96	26	MS	MS	NNP
cord-290566-tmsocyfc	96	27	.	.	.
cord-290566-tmsocyfc	97	1	Experimental	experimental	JJ
cord-290566-tmsocyfc	97	2	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	97	3	encephalomyelitis	encephalomyelitis	NN
cord-290566-tmsocyfc	97	4	(	(	-LRB-
cord-290566-tmsocyfc	97	5	EAE	EAE	NNP
cord-290566-tmsocyfc	97	6	)	)	-RRB-
cord-290566-tmsocyfc	97	7	is	be	VBZ
cord-290566-tmsocyfc	97	8	an	an	DT
cord-290566-tmsocyfc	97	9	inflammatory	inflammatory	JJ
cord-290566-tmsocyfc	97	10	central	central	JJ
cord-290566-tmsocyfc	97	11	nervous	nervous	JJ
cord-290566-tmsocyfc	97	12	system	system	NN
cord-290566-tmsocyfc	97	13	(	(	-LRB-
cord-290566-tmsocyfc	97	14	CNS	CNS	NNP
cord-290566-tmsocyfc	97	15	)	)	-RRB-
cord-290566-tmsocyfc	97	16	demyelinating	demyelinate	VBG
cord-290566-tmsocyfc	97	17	disease	disease	NN
cord-290566-tmsocyfc	97	18	,	,	,
cord-290566-tmsocyfc	97	19	and	and	CC
cord-290566-tmsocyfc	97	20	may	may	MD
cord-290566-tmsocyfc	97	21	be	be	VB
cord-290566-tmsocyfc	97	22	induced	induce	VBN
cord-290566-tmsocyfc	97	23	in	in	IN
cord-290566-tmsocyfc	97	24	several	several	JJ
cord-290566-tmsocyfc	97	25	animal	animal	NN
cord-290566-tmsocyfc	97	26	types	type	NNS
cord-290566-tmsocyfc	97	27	via	via	IN
cord-290566-tmsocyfc	97	28	immunization	immunization	NN
cord-290566-tmsocyfc	97	29	with	with	IN
cord-290566-tmsocyfc	97	30	myelin	myelin	NN
cord-290566-tmsocyfc	97	31	proteins	protein	NNS
cord-290566-tmsocyfc	97	32	or	or	CC
cord-290566-tmsocyfc	97	33	peptides	peptide	NNS
cord-290566-tmsocyfc	97	34	.	.	.
cord-290566-tmsocyfc	98	1	Disease	Disease	NNP
cord-290566-tmsocyfc	98	2	is	be	VBZ
cord-290566-tmsocyfc	98	3	primarily	primarily	RB
cord-290566-tmsocyfc	98	4	mediated	mediate	VBN
cord-290566-tmsocyfc	98	5	by	by	IN
cord-290566-tmsocyfc	98	6	myelin	myelin	NN
cord-290566-tmsocyfc	98	7	-	-	HYPH
cord-290566-tmsocyfc	98	8	reactive	reactive	JJ
cord-290566-tmsocyfc	98	9	Th1	th1	NN
cord-290566-tmsocyfc	98	10	cells	cell	NNS
cord-290566-tmsocyfc	98	11	,	,	,
cord-290566-tmsocyfc	98	12	which	which	WDT
cord-290566-tmsocyfc	98	13	precipitate	precipitate	VBP
cord-290566-tmsocyfc	98	14	an	an	DT
cord-290566-tmsocyfc	98	15	inflammatory	inflammatory	JJ
cord-290566-tmsocyfc	98	16	,	,	,
cord-290566-tmsocyfc	98	17	demyelinating	demyelinate	VBG
cord-290566-tmsocyfc	98	18	response	response	NN
cord-290566-tmsocyfc	98	19	within	within	IN
cord-290566-tmsocyfc	98	20	the	the	DT
cord-290566-tmsocyfc	98	21	CNS	CNS	NNP
cord-290566-tmsocyfc	99	1	(	(	-LRB-
cord-290566-tmsocyfc	99	2	Chitnis	Chitnis	NNP
cord-290566-tmsocyfc	99	3	et	et	NNP
cord-290566-tmsocyfc	99	4	al	al	NNP
cord-290566-tmsocyfc	99	5	.	.	NNP
cord-290566-tmsocyfc	99	6	,	,	,
cord-290566-tmsocyfc	99	7	2001b	2001b	CD
cord-290566-tmsocyfc	99	8	)	)	-RRB-
cord-290566-tmsocyfc	99	9	.	.	.
cord-290566-tmsocyfc	100	1	Transfer	transfer	NN
cord-290566-tmsocyfc	100	2	of	of	IN
cord-290566-tmsocyfc	100	3	myelin	myelin	JJ
cord-290566-tmsocyfc	100	4	basic	basic	JJ
cord-290566-tmsocyfc	100	5	protein	protein	NN
cord-290566-tmsocyfc	100	6	(	(	-LRB-
cord-290566-tmsocyfc	100	7	MBP)-specific	mbp)-specific	JJ
cord-290566-tmsocyfc	100	8	T	t	NN
cord-290566-tmsocyfc	100	9	-	-	HYPH
cord-290566-tmsocyfc	100	10	cell	cell	NN
cord-290566-tmsocyfc	100	11	clones	clone	NNS
cord-290566-tmsocyfc	100	12	restricted	restrict	VBN
cord-290566-tmsocyfc	100	13	to	to	IN
cord-290566-tmsocyfc	100	14	class	class	NN
cord-290566-tmsocyfc	100	15	II	II	NNP
cord-290566-tmsocyfc	100	16	(	(	-LRB-
cord-290566-tmsocyfc	100	17	Ia	Ia	NNP
cord-290566-tmsocyfc	100	18	)	)	-RRB-
cord-290566-tmsocyfc	100	19	antigens	antigen	NNS
cord-290566-tmsocyfc	100	20	of	of	IN
cord-290566-tmsocyfc	100	21	the	the	DT
cord-290566-tmsocyfc	100	22	MHC	MHC	NNP
cord-290566-tmsocyfc	100	23	into	into	IN
cord-290566-tmsocyfc	100	24	naive	naive	JJ
cord-290566-tmsocyfc	100	25	recipient	recipient	NN
cord-290566-tmsocyfc	100	26	animals	animal	NNS
cord-290566-tmsocyfc	100	27	causes	cause	VBZ
cord-290566-tmsocyfc	100	28	a	a	DT
cord-290566-tmsocyfc	100	29	similar	similar	JJ
cord-290566-tmsocyfc	100	30	inflammatory	inflammatory	JJ
cord-290566-tmsocyfc	100	31	demyelinating	demyelinating	NN
cord-290566-tmsocyfc	100	32	disease	disease	NN
cord-290566-tmsocyfc	100	33	(	(	-LRB-
cord-290566-tmsocyfc	100	34	Zamvil	Zamvil	NNP
cord-290566-tmsocyfc	100	35	et	et	NNP
cord-290566-tmsocyfc	100	36	al	al	NNP
cord-290566-tmsocyfc	100	37	.	.	NNP
cord-290566-tmsocyfc	100	38	,	,	,
cord-290566-tmsocyfc	100	39	1985	1985	CD
cord-290566-tmsocyfc	100	40	)	)	-RRB-
cord-290566-tmsocyfc	100	41	.	.	.
cord-290566-tmsocyfc	101	1	EAE	EAE	NNP
cord-290566-tmsocyfc	101	2	reproduces	reproduce	VBZ
cord-290566-tmsocyfc	101	3	many	many	JJ
cord-290566-tmsocyfc	101	4	of	of	IN
cord-290566-tmsocyfc	101	5	the	the	DT
cord-290566-tmsocyfc	101	6	clinical	clinical	JJ
cord-290566-tmsocyfc	101	7	and	and	CC
cord-290566-tmsocyfc	101	8	immunologic	immunologic	JJ
cord-290566-tmsocyfc	101	9	aspects	aspect	NNS
cord-290566-tmsocyfc	101	10	of	of	IN
cord-290566-tmsocyfc	101	11	MS	MS	NNP
cord-290566-tmsocyfc	101	12	,	,	,
cord-290566-tmsocyfc	101	13	and	and	CC
cord-290566-tmsocyfc	101	14	has	have	VBZ
cord-290566-tmsocyfc	101	15	been	be	VBN
cord-290566-tmsocyfc	101	16	widely	widely	RB
cord-290566-tmsocyfc	101	17	used	use	VBN
cord-290566-tmsocyfc	101	18	to	to	TO
cord-290566-tmsocyfc	101	19	study	study	VB
cord-290566-tmsocyfc	101	20	the	the	DT
cord-290566-tmsocyfc	101	21	mechanisms	mechanism	NNS
cord-290566-tmsocyfc	101	22	of	of	IN
cord-290566-tmsocyfc	101	23	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	101	24	T	T	NNP
cord-290566-tmsocyfc	101	25	-	-	HYPH
cord-290566-tmsocyfc	101	26	cell	cell	NN
cord-290566-tmsocyfc	101	27	priming	priming	NN
cord-290566-tmsocyfc	101	28	and	and	CC
cord-290566-tmsocyfc	101	29	response	response	NN
cord-290566-tmsocyfc	101	30	to	to	IN
cord-290566-tmsocyfc	101	31	myelin	myelin	NN
cord-290566-tmsocyfc	101	32	components	component	NNS
cord-290566-tmsocyfc	101	33	(	(	-LRB-
cord-290566-tmsocyfc	101	34	Bettelli	Bettelli	NNP
cord-290566-tmsocyfc	101	35	et	et	FW
cord-290566-tmsocyfc	101	36	al	al	NNP
cord-290566-tmsocyfc	101	37	.	.	NNP
cord-290566-tmsocyfc	101	38	,	,	,
cord-290566-tmsocyfc	101	39	1998	1998	CD
cord-290566-tmsocyfc	101	40	;	;	:
cord-290566-tmsocyfc	102	1	Chitnis	Chitnis	NNP
cord-290566-tmsocyfc	102	2	et	et	NNP
cord-290566-tmsocyfc	102	3	al	al	NNP
cord-290566-tmsocyfc	102	4	.	.	.
cord-290566-tmsocyfc	103	1	,	,	,
cord-290566-tmsocyfc	103	2	2001a	2001a	CD
cord-290566-tmsocyfc	103	3	)	)	-RRB-
cord-290566-tmsocyfc	103	4	as	as	RB
cord-290566-tmsocyfc	103	5	well	well	RB
cord-290566-tmsocyfc	103	6	as	as	IN
cord-290566-tmsocyfc	103	7	to	to	TO
cord-290566-tmsocyfc	103	8	test	test	VB
cord-290566-tmsocyfc	103	9	potential	potential	JJ
cord-290566-tmsocyfc	103	10	therapies	therapy	NNS
cord-290566-tmsocyfc	103	11	for	for	IN
cord-290566-tmsocyfc	103	12	MS	MS	NNP
cord-290566-tmsocyfc	103	13	(	(	-LRB-
cord-290566-tmsocyfc	103	14	Aharoni	Aharoni	NNP
cord-290566-tmsocyfc	103	15	et	et	FW
cord-290566-tmsocyfc	103	16	al	al	NNP
cord-290566-tmsocyfc	103	17	.	.	NNP
cord-290566-tmsocyfc	103	18	,	,	,
cord-290566-tmsocyfc	103	19	1999	1999	CD
cord-290566-tmsocyfc	103	20	;	;	:
cord-290566-tmsocyfc	103	21	Yednock	Yednock	NNP
cord-290566-tmsocyfc	103	22	et	et	NNP
cord-290566-tmsocyfc	103	23	al	al	NNP
cord-290566-tmsocyfc	103	24	.	.	NNP
cord-290566-tmsocyfc	103	25	,	,	,
cord-290566-tmsocyfc	103	26	1992	1992	CD
cord-290566-tmsocyfc	103	27	)	)	-RRB-
cord-290566-tmsocyfc	103	28	.	.	.
cord-290566-tmsocyfc	104	1	Theiler	Theiler	NNP
cord-290566-tmsocyfc	104	2	's	's	POS
cord-290566-tmsocyfc	104	3	murine	murine	JJ
cord-290566-tmsocyfc	104	4	encephalomyelitis	encephalomyelitis	NN
cord-290566-tmsocyfc	104	5	virus	virus	NN
cord-290566-tmsocyfc	104	6	-	-	HYPH
cord-290566-tmsocyfc	104	7	induced	induce	VBN
cord-290566-tmsocyfc	104	8	demyelinating	demyelinate	VBG
cord-290566-tmsocyfc	104	9	disease	disease	NN
cord-290566-tmsocyfc	104	10	(	(	-LRB-
cord-290566-tmsocyfc	104	11	TMEV	TMEV	NNP
cord-290566-tmsocyfc	104	12	-	-	HYPH
cord-290566-tmsocyfc	104	13	IDD	IDD	NNP
cord-290566-tmsocyfc	104	14	)	)	-RRB-
cord-290566-tmsocyfc	104	15	model	model	NN
cord-290566-tmsocyfc	104	16	is	be	VBZ
cord-290566-tmsocyfc	104	17	a	a	DT
cord-290566-tmsocyfc	104	18	virally	virally	RB
cord-290566-tmsocyfc	104	19	mediated	mediate	VBN
cord-290566-tmsocyfc	104	20	model	model	NN
cord-290566-tmsocyfc	104	21	of	of	IN
cord-290566-tmsocyfc	104	22	CNS	CNS	NNP
cord-290566-tmsocyfc	104	23	inflammatory	inflammatory	JJ
cord-290566-tmsocyfc	104	24	demyelination	demyelination	NN
cord-290566-tmsocyfc	104	25	,	,	,
cord-290566-tmsocyfc	104	26	with	with	IN
cord-290566-tmsocyfc	104	27	some	some	DT
cord-290566-tmsocyfc	104	28	resemblance	resemblance	NN
cord-290566-tmsocyfc	104	29	to	to	IN
cord-290566-tmsocyfc	104	30	MS	MS	NNP
cord-290566-tmsocyfc	104	31	and	and	CC
cord-290566-tmsocyfc	104	32	is	be	VBZ
cord-290566-tmsocyfc	104	33	induced	induce	VBN
cord-290566-tmsocyfc	104	34	by	by	IN
cord-290566-tmsocyfc	104	35	direct	direct	JJ
cord-290566-tmsocyfc	104	36	CNS	CNS	NNP
cord-290566-tmsocyfc	104	37	infection	infection	NN
cord-290566-tmsocyfc	104	38	of	of	IN
cord-290566-tmsocyfc	104	39	the	the	DT
cord-290566-tmsocyfc	104	40	neurotropic	neurotropic	NNP
cord-290566-tmsocyfc	104	41	TMEV	TMEV	NNP
cord-290566-tmsocyfc	104	42	picornavirus	picornavirus	NN
cord-290566-tmsocyfc	104	43	,	,	,
cord-290566-tmsocyfc	104	44	initially	initially	RB
cord-290566-tmsocyfc	104	45	resulting	result	VBG
cord-290566-tmsocyfc	104	46	in	in	IN
cord-290566-tmsocyfc	104	47	an	an	DT
cord-290566-tmsocyfc	104	48	immune	immune	NN
cord-290566-tmsocyfc	104	49	-	-	HYPH
cord-290566-tmsocyfc	104	50	mediated	mediate	VBN
cord-290566-tmsocyfc	104	51	reaction	reaction	NN
cord-290566-tmsocyfc	104	52	primarily	primarily	RB
cord-290566-tmsocyfc	104	53	involving	involve	VBG
cord-290566-tmsocyfc	104	54	TMEV	TMEV	NNP
cord-290566-tmsocyfc	104	55	-	-	HYPH
cord-290566-tmsocyfc	104	56	specific	specific	JJ
cord-290566-tmsocyfc	104	57	CD4	CD4	NNP
cord-290566-tmsocyfc	104	58	and	and	CC
cord-290566-tmsocyfc	104	59	CD8	CD8	NNP
cord-290566-tmsocyfc	104	60	T	T	NNP
cord-290566-tmsocyfc	104	61	cells	cell	NNS
cord-290566-tmsocyfc	104	62	(	(	-LRB-
cord-290566-tmsocyfc	104	63	Clatch	Clatch	NNP
cord-290566-tmsocyfc	104	64	et	et	NNP
cord-290566-tmsocyfc	104	65	al	al	NNP
cord-290566-tmsocyfc	104	66	.	.	NNP
cord-290566-tmsocyfc	104	67	,	,	,
cord-290566-tmsocyfc	104	68	1986	1986	CD
cord-290566-tmsocyfc	104	69	;	;	:
cord-290566-tmsocyfc	104	70	Rodriguez	Rodriguez	NNP
cord-290566-tmsocyfc	104	71	et	et	NNP
cord-290566-tmsocyfc	104	72	al	al	NNP
cord-290566-tmsocyfc	104	73	.	.	NNP
cord-290566-tmsocyfc	104	74	,	,	,
cord-290566-tmsocyfc	104	75	1996	1996	CD
cord-290566-tmsocyfc	104	76	)	)	-RRB-
cord-290566-tmsocyfc	104	77	.	.	.
cord-290566-tmsocyfc	105	1	However	however	RB
cord-290566-tmsocyfc	105	2	,	,	,
cord-290566-tmsocyfc	105	3	during	during	IN
cord-290566-tmsocyfc	105	4	the	the	DT
cord-290566-tmsocyfc	105	5	chronic	chronic	JJ
cord-290566-tmsocyfc	105	6	stages	stage	NNS
cord-290566-tmsocyfc	105	7	of	of	IN
cord-290566-tmsocyfc	105	8	disease	disease	NN
cord-290566-tmsocyfc	105	9	,	,	,
cord-290566-tmsocyfc	105	10	T	t	NN
cord-290566-tmsocyfc	105	11	-	-	HYPH
cord-290566-tmsocyfc	105	12	cell	cell	NN
cord-290566-tmsocyfc	105	13	reactivity	reactivity	NN
cord-290566-tmsocyfc	105	14	to	to	TO
cord-290566-tmsocyfc	105	15	host	host	VB
cord-290566-tmsocyfc	105	16	myelin	myelin	NN
cord-290566-tmsocyfc	105	17	peptides	peptide	NNS
cord-290566-tmsocyfc	105	18	has	have	VBZ
cord-290566-tmsocyfc	105	19	been	be	VBN
cord-290566-tmsocyfc	105	20	observed	observe	VBN
cord-290566-tmsocyfc	105	21	,	,	,
cord-290566-tmsocyfc	105	22	indicating	indicate	VBG
cord-290566-tmsocyfc	105	23	epitope	epitope	NN
cord-290566-tmsocyfc	105	24	spreading	spreading	NN
cord-290566-tmsocyfc	105	25	has	have	VBZ
cord-290566-tmsocyfc	105	26	occurred	occur	VBN
cord-290566-tmsocyfc	105	27	,	,	,
cord-290566-tmsocyfc	105	28	causing	cause	VBG
cord-290566-tmsocyfc	105	29	secondary	secondary	JJ
cord-290566-tmsocyfc	105	30	T	t	NN
cord-290566-tmsocyfc	105	31	-	-	HYPH
cord-290566-tmsocyfc	105	32	cell	cell	NN
cord-290566-tmsocyfc	105	33	responses	response	NNS
cord-290566-tmsocyfc	105	34	to	to	IN
cord-290566-tmsocyfc	105	35	myelin	myelin	JJ
cord-290566-tmsocyfc	105	36	breakdown	breakdown	NN
cord-290566-tmsocyfc	105	37	products	product	NNS
cord-290566-tmsocyfc	105	38	,	,	,
cord-290566-tmsocyfc	105	39	and	and	CC
cord-290566-tmsocyfc	105	40	resulting	result	VBG
cord-290566-tmsocyfc	105	41	in	in	IN
cord-290566-tmsocyfc	105	42	a	a	DT
cord-290566-tmsocyfc	105	43	disseminated	disseminate	VBN
cord-290566-tmsocyfc	105	44	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	105	45	response	response	NN
cord-290566-tmsocyfc	105	46	.	.	.
cord-290566-tmsocyfc	106	1	A	a	DT
cord-290566-tmsocyfc	106	2	summary	summary	NN
cord-290566-tmsocyfc	106	3	of	of	IN
cord-290566-tmsocyfc	106	4	T	t	NN
cord-290566-tmsocyfc	106	5	-	-	HYPH
cord-290566-tmsocyfc	106	6	cell	cell	NN
cord-290566-tmsocyfc	106	7	immunology	immunology	NN
cord-290566-tmsocyfc	106	8	related	relate	VBN
cord-290566-tmsocyfc	106	9	to	to	IN
cord-290566-tmsocyfc	106	10	animal	animal	NN
cord-290566-tmsocyfc	106	11	models	model	NNS
cord-290566-tmsocyfc	106	12	of	of	IN
cord-290566-tmsocyfc	106	13	MS	MS	NNP
cord-290566-tmsocyfc	106	14	is	be	VBZ
cord-290566-tmsocyfc	106	15	beyond	beyond	IN
cord-290566-tmsocyfc	106	16	the	the	DT
cord-290566-tmsocyfc	106	17	scope	scope	NN
cord-290566-tmsocyfc	106	18	of	of	IN
cord-290566-tmsocyfc	106	19	this	this	DT
cord-290566-tmsocyfc	106	20	chapter	chapter	NN
cord-290566-tmsocyfc	106	21	,	,	,
cord-290566-tmsocyfc	106	22	and	and	CC
cord-290566-tmsocyfc	106	23	can	can	MD
cord-290566-tmsocyfc	106	24	be	be	VB
cord-290566-tmsocyfc	106	25	found	find	VBN
cord-290566-tmsocyfc	106	26	elsewhere	elsewhere	RB
cord-290566-tmsocyfc	106	27	in	in	IN
cord-290566-tmsocyfc	106	28	this	this	DT
cord-290566-tmsocyfc	106	29	volume	volume	NN
cord-290566-tmsocyfc	106	30	or	or	CC
cord-290566-tmsocyfc	106	31	in	in	IN
cord-290566-tmsocyfc	106	32	alternate	alternate	JJ
cord-290566-tmsocyfc	106	33	sources	source	NNS
cord-290566-tmsocyfc	106	34	(	(	-LRB-
cord-290566-tmsocyfc	106	35	Chitnis	Chitnis	NNP
cord-290566-tmsocyfc	106	36	and	and	CC
cord-290566-tmsocyfc	106	37	Khoury	Khoury	NNP
cord-290566-tmsocyfc	106	38	,	,	,
cord-290566-tmsocyfc	106	39	2003a	2003a	CD
cord-290566-tmsocyfc	106	40	,	,	,
cord-290566-tmsocyfc	106	41	b	b	LS
cord-290566-tmsocyfc	106	42	)	)	-RRB-
cord-290566-tmsocyfc	106	43	;	;	:
cord-290566-tmsocyfc	106	44	however	however	RB
cord-290566-tmsocyfc	106	45	,	,	,
cord-290566-tmsocyfc	106	46	selected	select	VBN
cord-290566-tmsocyfc	106	47	topics	topic	NNS
cord-290566-tmsocyfc	106	48	in	in	IN
cord-290566-tmsocyfc	106	49	MS	MS	NNP
cord-290566-tmsocyfc	106	50	that	that	WDT
cord-290566-tmsocyfc	106	51	are	be	VBP
cord-290566-tmsocyfc	106	52	illuminated	illuminate	VBN
cord-290566-tmsocyfc	106	53	by	by	IN
cord-290566-tmsocyfc	106	54	animal	animal	NN
cord-290566-tmsocyfc	106	55	studies	study	NNS
cord-290566-tmsocyfc	106	56	are	be	VBP
cord-290566-tmsocyfc	106	57	discussed	discuss	VBN
cord-290566-tmsocyfc	106	58	.	.	.
cord-290566-tmsocyfc	107	1	The	the	DT
cord-290566-tmsocyfc	107	2	prevailing	prevail	VBG
cord-290566-tmsocyfc	107	3	theory	theory	NN
cord-290566-tmsocyfc	107	4	of	of	IN
cord-290566-tmsocyfc	107	5	the	the	DT
cord-290566-tmsocyfc	107	6	etiology	etiology	NN
cord-290566-tmsocyfc	107	7	of	of	IN
cord-290566-tmsocyfc	107	8	MS	MS	NNP
cord-290566-tmsocyfc	107	9	is	be	VBZ
cord-290566-tmsocyfc	107	10	that	that	DT
cord-290566-tmsocyfc	107	11	of	of	IN
cord-290566-tmsocyfc	107	12	'	'	``
cord-290566-tmsocyfc	107	13	'	'	``
cord-290566-tmsocyfc	107	14	molecular	molecular	JJ
cord-290566-tmsocyfc	107	15	mimicry	mimicry	NN
cord-290566-tmsocyfc	107	16	'	'	''
cord-290566-tmsocyfc	107	17	'	'	''
cord-290566-tmsocyfc	107	18	whereby	whereby	WRB
cord-290566-tmsocyfc	107	19	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	107	20	T	T	NNP
cord-290566-tmsocyfc	107	21	cells	cell	NNS
cord-290566-tmsocyfc	107	22	activated	activate	VBN
cord-290566-tmsocyfc	107	23	by	by	IN
cord-290566-tmsocyfc	107	24	a	a	DT
cord-290566-tmsocyfc	107	25	foreign	foreign	JJ
cord-290566-tmsocyfc	107	26	antigen	antigen	NN
cord-290566-tmsocyfc	107	27	cross	cross	NN
cord-290566-tmsocyfc	107	28	-	-	NN
cord-290566-tmsocyfc	107	29	react	react	VB
cord-290566-tmsocyfc	107	30	with	with	IN
cord-290566-tmsocyfc	107	31	myelin	myelin	JJ
cord-290566-tmsocyfc	107	32	antigens	antigen	NNS
cord-290566-tmsocyfc	107	33	.	.	.
cord-290566-tmsocyfc	108	1	Activated	activate	VBN
cord-290566-tmsocyfc	108	2	myelin	myelin	NN
cord-290566-tmsocyfc	108	3	-	-	HYPH
cord-290566-tmsocyfc	108	4	reactive	reactive	JJ
cord-290566-tmsocyfc	108	5	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	108	6	T	T	NNP
cord-290566-tmsocyfc	108	7	cells	cell	NNS
cord-290566-tmsocyfc	108	8	are	be	VBP
cord-290566-tmsocyfc	108	9	present	present	JJ
cord-290566-tmsocyfc	108	10	in	in	IN
cord-290566-tmsocyfc	108	11	the	the	DT
cord-290566-tmsocyfc	108	12	blood	blood	NN
cord-290566-tmsocyfc	108	13	and	and	CC
cord-290566-tmsocyfc	108	14	cerebrospinal	cerebrospinal	NN
cord-290566-tmsocyfc	108	15	fluid	fluid	NN
cord-290566-tmsocyfc	108	16	(	(	-LRB-
cord-290566-tmsocyfc	108	17	CSF	CSF	NNP
cord-290566-tmsocyfc	108	18	)	)	-RRB-
cord-290566-tmsocyfc	108	19	of	of	IN
cord-290566-tmsocyfc	108	20	MS	MS	NNP
cord-290566-tmsocyfc	108	21	patients	patient	NNS
cord-290566-tmsocyfc	108	22	;	;	:
cord-290566-tmsocyfc	108	23	in	in	IN
cord-290566-tmsocyfc	108	24	contrast	contrast	NN
cord-290566-tmsocyfc	108	25	,	,	,
cord-290566-tmsocyfc	108	26	only	only	RB
cord-290566-tmsocyfc	108	27	nonactivated	nonactivate	VBD
cord-290566-tmsocyfc	108	28	myelinreactive	myelinreactive	NNP
cord-290566-tmsocyfc	108	29	T	T	NNP
cord-290566-tmsocyfc	108	30	cells	cell	NNS
cord-290566-tmsocyfc	108	31	are	be	VBP
cord-290566-tmsocyfc	108	32	present	present	JJ
cord-290566-tmsocyfc	108	33	in	in	IN
cord-290566-tmsocyfc	108	34	the	the	DT
cord-290566-tmsocyfc	108	35	blood	blood	NN
cord-290566-tmsocyfc	108	36	of	of	IN
cord-290566-tmsocyfc	108	37	controls	control	NNS
cord-290566-tmsocyfc	109	1	(	(	-LRB-
cord-290566-tmsocyfc	109	2	Zhang	Zhang	NNP
cord-290566-tmsocyfc	109	3	et	et	NNP
cord-290566-tmsocyfc	109	4	al	al	NNP
cord-290566-tmsocyfc	109	5	.	.	NNP
cord-290566-tmsocyfc	109	6	,	,	,
cord-290566-tmsocyfc	109	7	1994	1994	CD
cord-290566-tmsocyfc	109	8	)	)	-RRB-
cord-290566-tmsocyfc	109	9	.	.	.
cord-290566-tmsocyfc	110	1	Sequences	sequence	NNS
cord-290566-tmsocyfc	110	2	in	in	IN
cord-290566-tmsocyfc	110	3	MBP	MBP	NNP
cord-290566-tmsocyfc	110	4	has	have	VBZ
cord-290566-tmsocyfc	110	5	been	be	VBN
cord-290566-tmsocyfc	110	6	shown	show	VBN
cord-290566-tmsocyfc	110	7	to	to	TO
cord-290566-tmsocyfc	110	8	resemble	resemble	VB
cord-290566-tmsocyfc	110	9	several	several	JJ
cord-290566-tmsocyfc	110	10	viral	viral	JJ
cord-290566-tmsocyfc	110	11	sequences	sequence	NNS
cord-290566-tmsocyfc	110	12	,	,	,
cord-290566-tmsocyfc	110	13	and	and	CC
cord-290566-tmsocyfc	110	14	in	in	IN
cord-290566-tmsocyfc	110	15	some	some	DT
cord-290566-tmsocyfc	110	16	cases	case	NNS
cord-290566-tmsocyfc	110	17	,	,	,
cord-290566-tmsocyfc	110	18	crossreactive	crossreactive	JJ
cord-290566-tmsocyfc	110	19	T	t	NN
cord-290566-tmsocyfc	110	20	-	-	HYPH
cord-290566-tmsocyfc	110	21	cell	cell	NN
cord-290566-tmsocyfc	110	22	responses	response	NNS
cord-290566-tmsocyfc	110	23	have	have	VBP
cord-290566-tmsocyfc	110	24	been	be	VBN
cord-290566-tmsocyfc	110	25	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	110	26	.	.	.
cord-290566-tmsocyfc	111	1	Although	although	IN
cord-290566-tmsocyfc	111	2	no	no	DT
cord-290566-tmsocyfc	111	3	pathogen	pathogen	NN
cord-290566-tmsocyfc	111	4	has	have	VBZ
cord-290566-tmsocyfc	111	5	definitely	definitely	RB
cord-290566-tmsocyfc	111	6	been	be	VBN
cord-290566-tmsocyfc	111	7	proven	prove	VBN
cord-290566-tmsocyfc	111	8	to	to	TO
cord-290566-tmsocyfc	111	9	be	be	VB
cord-290566-tmsocyfc	111	10	the	the	DT
cord-290566-tmsocyfc	111	11	cause	cause	NN
cord-290566-tmsocyfc	111	12	of	of	IN
cord-290566-tmsocyfc	111	13	MS	MS	NNP
cord-290566-tmsocyfc	111	14	,	,	,
cord-290566-tmsocyfc	111	15	it	-PRON-	PRP
cord-290566-tmsocyfc	111	16	is	be	VBZ
cord-290566-tmsocyfc	111	17	conceivable	conceivable	JJ
cord-290566-tmsocyfc	111	18	that	that	IN
cord-290566-tmsocyfc	111	19	certain	certain	JJ
cord-290566-tmsocyfc	111	20	pathogens	pathogen	NNS
cord-290566-tmsocyfc	111	21	serve	serve	VBP
cord-290566-tmsocyfc	111	22	as	as	IN
cord-290566-tmsocyfc	111	23	molecular	molecular	JJ
cord-290566-tmsocyfc	111	24	mimics	mimic	NNS
cord-290566-tmsocyfc	111	25	to	to	IN
cord-290566-tmsocyfc	111	26	CNS	CNS	NNP
cord-290566-tmsocyfc	111	27	components	component	NNS
cord-290566-tmsocyfc	111	28	or	or	CC
cord-290566-tmsocyfc	111	29	play	play	VB
cord-290566-tmsocyfc	111	30	a	a	DT
cord-290566-tmsocyfc	111	31	role	role	NN
cord-290566-tmsocyfc	111	32	in	in	IN
cord-290566-tmsocyfc	111	33	the	the	DT
cord-290566-tmsocyfc	111	34	activation	activation	NN
cord-290566-tmsocyfc	111	35	of	of	IN
cord-290566-tmsocyfc	111	36	myelin	myelin	NN
cord-290566-tmsocyfc	111	37	-	-	HYPH
cord-290566-tmsocyfc	111	38	specific	specific	JJ
cord-290566-tmsocyfc	111	39	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	111	40	T	T	NNP
cord-290566-tmsocyfc	111	41	cells	cell	NNS
cord-290566-tmsocyfc	111	42	.	.	.
cord-290566-tmsocyfc	112	1	Examples	example	NNS
cord-290566-tmsocyfc	112	2	of	of	IN
cord-290566-tmsocyfc	112	3	cross	cross	JJ
cord-290566-tmsocyfc	112	4	-	-	JJ
cord-290566-tmsocyfc	112	5	reactive	reactive	JJ
cord-290566-tmsocyfc	112	6	T	t	NN
cord-290566-tmsocyfc	112	7	cells	cell	NNS
cord-290566-tmsocyfc	112	8	with	with	IN
cord-290566-tmsocyfc	112	9	MBP	MBP	NNP
cord-290566-tmsocyfc	112	10	antigens	antigen	NNS
cord-290566-tmsocyfc	112	11	include	include	VBP
cord-290566-tmsocyfc	112	12	human	human	JJ
cord-290566-tmsocyfc	112	13	herpesvirus	herpesvirus	NN
cord-290566-tmsocyfc	112	14	6	6	CD
cord-290566-tmsocyfc	112	15	(	(	-LRB-
cord-290566-tmsocyfc	112	16	HHV-6	HHV-6	NNP
cord-290566-tmsocyfc	112	17	)	)	-RRB-
cord-290566-tmsocyfc	113	1	(	(	-LRB-
cord-290566-tmsocyfc	113	2	Tejada	Tejada	NNP
cord-290566-tmsocyfc	113	3	-	-	HYPH
cord-290566-tmsocyfc	113	4	Simon	Simon	NNP
cord-290566-tmsocyfc	113	5	et	et	NNP
cord-290566-tmsocyfc	113	6	al	al	NNP
cord-290566-tmsocyfc	113	7	.	.	NNP
cord-290566-tmsocyfc	113	8	,	,	,
cord-290566-tmsocyfc	113	9	2003	2003	CD
cord-290566-tmsocyfc	113	10	)	)	-RRB-
cord-290566-tmsocyfc	113	11	,	,	,
cord-290566-tmsocyfc	113	12	staphylococcal	staphylococcal	JJ
cord-290566-tmsocyfc	113	13	enterotoxin	enterotoxin	NN
cord-290566-tmsocyfc	113	14	antigens	antigen	NNS
cord-290566-tmsocyfc	113	15	,	,	,
cord-290566-tmsocyfc	113	16	coronavirus	coronavirus	NN
cord-290566-tmsocyfc	113	17	(	(	-LRB-
cord-290566-tmsocyfc	113	18	Talbot	Talbot	NNP
cord-290566-tmsocyfc	113	19	et	et	NNP
cord-290566-tmsocyfc	113	20	al	al	NNP
cord-290566-tmsocyfc	113	21	.	.	NNP
cord-290566-tmsocyfc	113	22	,	,	,
cord-290566-tmsocyfc	113	23	1996	1996	CD
cord-290566-tmsocyfc	113	24	)	)	-RRB-
cord-290566-tmsocyfc	113	25	,	,	,
cord-290566-tmsocyfc	113	26	influenza	influenza	NN
cord-290566-tmsocyfc	113	27	virus	virus	NN
cord-290566-tmsocyfc	113	28	hemagglutinin	hemagglutinin	NN
cord-290566-tmsocyfc	113	29	(	(	-LRB-
cord-290566-tmsocyfc	113	30	Markovic	Markovic	NNP
cord-290566-tmsocyfc	113	31	-	-	HYPH
cord-290566-tmsocyfc	113	32	Plese	Plese	NNP
cord-290566-tmsocyfc	113	33	et	et	NNP
cord-290566-tmsocyfc	113	34	al	al	NNP
cord-290566-tmsocyfc	113	35	.	.	NNP
cord-290566-tmsocyfc	113	36	,	,	,
cord-290566-tmsocyfc	113	37	2005	2005	CD
cord-290566-tmsocyfc	113	38	)	)	-RRB-
cord-290566-tmsocyfc	113	39	,	,	,
cord-290566-tmsocyfc	113	40	and	and	CC
cord-290566-tmsocyfc	113	41	Epstein	Epstein	NNP
cord-290566-tmsocyfc	113	42	-	-	HYPH
cord-290566-tmsocyfc	113	43	Barr	Barr	NNP
cord-290566-tmsocyfc	113	44	virus	virus	NN
cord-290566-tmsocyfc	113	45	(	(	-LRB-
cord-290566-tmsocyfc	113	46	EBV	EBV	NNP
cord-290566-tmsocyfc	113	47	)	)	-RRB-
cord-290566-tmsocyfc	114	1	(	(	-LRB-
cord-290566-tmsocyfc	114	2	Lang	Lang	NNP
cord-290566-tmsocyfc	114	3	et	et	NNP
cord-290566-tmsocyfc	114	4	al	al	NNP
cord-290566-tmsocyfc	114	5	.	.	NNP
cord-290566-tmsocyfc	114	6	,	,	,
cord-290566-tmsocyfc	114	7	2002	2002	CD
cord-290566-tmsocyfc	114	8	)	)	-RRB-
cord-290566-tmsocyfc	114	9	.	.	.
cord-290566-tmsocyfc	115	1	Proteolipid	Proteolipid	NNP
cord-290566-tmsocyfc	115	2	protein	protein	NN
cord-290566-tmsocyfc	115	3	(	(	-LRB-
cord-290566-tmsocyfc	115	4	PLP	PLP	NNP
cord-290566-tmsocyfc	115	5	)	)	-RRB-
cord-290566-tmsocyfc	115	6	shares	share	VBZ
cord-290566-tmsocyfc	115	7	common	common	JJ
cord-290566-tmsocyfc	115	8	sequences	sequence	NNS
cord-290566-tmsocyfc	115	9	with	with	IN
cord-290566-tmsocyfc	115	10	Haemophilus	Haemophilus	NNP
cord-290566-tmsocyfc	115	11	influenzae	influenzae	NN
cord-290566-tmsocyfc	115	12	(	(	-LRB-
cord-290566-tmsocyfc	115	13	Olson	Olson	NNP
cord-290566-tmsocyfc	115	14	et	et	NNP
cord-290566-tmsocyfc	115	15	al	al	NNP
cord-290566-tmsocyfc	115	16	.	.	NNP
cord-290566-tmsocyfc	115	17	,	,	,
cord-290566-tmsocyfc	115	18	2001	2001	CD
cord-290566-tmsocyfc	115	19	)	)	-RRB-
cord-290566-tmsocyfc	115	20	,	,	,
cord-290566-tmsocyfc	115	21	while	while	IN
cord-290566-tmsocyfc	115	22	Semliki	Semliki	NNP
cord-290566-tmsocyfc	115	23	Forest	Forest	NNP
cord-290566-tmsocyfc	115	24	virus	virus	NN
cord-290566-tmsocyfc	115	25	(	(	-LRB-
cord-290566-tmsocyfc	115	26	SFV	SFV	NNP
cord-290566-tmsocyfc	115	27	)	)	-RRB-
cord-290566-tmsocyfc	115	28	peptides	peptide	NNS
cord-290566-tmsocyfc	115	29	mimic	mimic	VBP
cord-290566-tmsocyfc	115	30	epitopes	epitope	NNS
cord-290566-tmsocyfc	115	31	of	of	IN
cord-290566-tmsocyfc	115	32	myelin	myelin	NN
cord-290566-tmsocyfc	115	33	oligodendrocyte	oligodendrocyte	NNP
cord-290566-tmsocyfc	115	34	glycoprotein	glycoprotein	NN
cord-290566-tmsocyfc	115	35	(	(	-LRB-
cord-290566-tmsocyfc	115	36	MOG	MOG	NNP
cord-290566-tmsocyfc	115	37	)	)	-RRB-
cord-290566-tmsocyfc	115	38	(	(	-LRB-
cord-290566-tmsocyfc	115	39	Mokhtarian	Mokhtarian	NNP
cord-290566-tmsocyfc	115	40	et	et	NNP
cord-290566-tmsocyfc	115	41	al	al	NNP
cord-290566-tmsocyfc	115	42	.	.	NNP
cord-290566-tmsocyfc	115	43	,	,	,
cord-290566-tmsocyfc	115	44	1999	1999	CD
cord-290566-tmsocyfc	115	45	)	)	-RRB-
cord-290566-tmsocyfc	115	46	.	.	.
cord-290566-tmsocyfc	116	1	These	these	DT
cord-290566-tmsocyfc	116	2	activated	activate	VBN
cord-290566-tmsocyfc	116	3	T	t	NN
cord-290566-tmsocyfc	116	4	cells	cell	NNS
cord-290566-tmsocyfc	116	5	are	be	VBP
cord-290566-tmsocyfc	116	6	then	then	RB
cord-290566-tmsocyfc	116	7	thought	think	VBN
cord-290566-tmsocyfc	116	8	to	to	TO
cord-290566-tmsocyfc	116	9	migrate	migrate	VB
cord-290566-tmsocyfc	116	10	to	to	IN
cord-290566-tmsocyfc	116	11	the	the	DT
cord-290566-tmsocyfc	116	12	CNS	CNS	NNP
cord-290566-tmsocyfc	116	13	,	,	,
cord-290566-tmsocyfc	116	14	where	where	WRB
cord-290566-tmsocyfc	116	15	they	-PRON-	PRP
cord-290566-tmsocyfc	116	16	undergo	undergo	VBP
cord-290566-tmsocyfc	116	17	reactivation	reactivation	NN
cord-290566-tmsocyfc	116	18	in	in	IN
cord-290566-tmsocyfc	116	19	response	response	NN
cord-290566-tmsocyfc	116	20	to	to	IN
cord-290566-tmsocyfc	116	21	nascent	nascent	JJ
cord-290566-tmsocyfc	116	22	myelin	myelin	NN
cord-290566-tmsocyfc	116	23	antigens	antigen	NNS
cord-290566-tmsocyfc	116	24	.	.	.
cord-290566-tmsocyfc	117	1	The	the	DT
cord-290566-tmsocyfc	117	2	reactivation	reactivation	NN
cord-290566-tmsocyfc	117	3	of	of	IN
cord-290566-tmsocyfc	117	4	T	t	NN
cord-290566-tmsocyfc	117	5	cells	cell	NNS
cord-290566-tmsocyfc	117	6	heralds	herald	VBZ
cord-290566-tmsocyfc	117	7	an	an	DT
cord-290566-tmsocyfc	117	8	inflammatory	inflammatory	JJ
cord-290566-tmsocyfc	117	9	response	response	NN
cord-290566-tmsocyfc	117	10	within	within	IN
cord-290566-tmsocyfc	117	11	the	the	DT
cord-290566-tmsocyfc	117	12	CNS	CNS	NNP
cord-290566-tmsocyfc	117	13	,	,	,
cord-290566-tmsocyfc	117	14	resulting	result	VBG
cord-290566-tmsocyfc	117	15	in	in	IN
cord-290566-tmsocyfc	117	16	more	more	JJR
cord-290566-tmsocyfc	117	17	tissue	tissue	NN
cord-290566-tmsocyfc	117	18	damage	damage	NN
cord-290566-tmsocyfc	117	19	and	and	CC
cord-290566-tmsocyfc	117	20	release	release	NN
cord-290566-tmsocyfc	117	21	of	of	IN
cord-290566-tmsocyfc	117	22	secondary	secondary	JJ
cord-290566-tmsocyfc	117	23	antigens	antigen	NNS
cord-290566-tmsocyfc	117	24	.	.	.
cord-290566-tmsocyfc	118	1	Subsequent	subsequent	JJ
cord-290566-tmsocyfc	118	2	T	t	NN
cord-290566-tmsocyfc	118	3	-	-	HYPH
cord-290566-tmsocyfc	118	4	cell	cell	NN
cord-290566-tmsocyfc	118	5	reactivity	reactivity	NN
cord-290566-tmsocyfc	118	6	to	to	IN
cord-290566-tmsocyfc	118	7	secondary	secondary	JJ
cord-290566-tmsocyfc	118	8	antigens	antigen	NNS
cord-290566-tmsocyfc	118	9	is	be	VBZ
cord-290566-tmsocyfc	118	10	termed	term	VBN
cord-290566-tmsocyfc	118	11	'	'	``
cord-290566-tmsocyfc	118	12	'	'	``
cord-290566-tmsocyfc	118	13	epitope	epitope	NN
cord-290566-tmsocyfc	118	14	spreading	spreading	NN
cord-290566-tmsocyfc	118	15	.	.	.
cord-290566-tmsocyfc	118	16	'	'	''
cord-290566-tmsocyfc	119	1	'	'	``
cord-290566-tmsocyfc	119	2	Evidence	evidence	NN
cord-290566-tmsocyfc	119	3	of	of	IN
cord-290566-tmsocyfc	119	4	epitope	epitope	NN
cord-290566-tmsocyfc	119	5	spreading	spreading	NN
cord-290566-tmsocyfc	119	6	has	have	VBZ
cord-290566-tmsocyfc	119	7	been	be	VBN
cord-290566-tmsocyfc	119	8	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	119	9	in	in	IN
cord-290566-tmsocyfc	119	10	animal	animal	NN
cord-290566-tmsocyfc	119	11	models	model	NNS
cord-290566-tmsocyfc	119	12	of	of	IN
cord-290566-tmsocyfc	119	13	MS	MS	NNP
cord-290566-tmsocyfc	119	14	(	(	-LRB-
cord-290566-tmsocyfc	119	15	McMahon	McMahon	NNP
cord-290566-tmsocyfc	119	16	et	et	NNP
cord-290566-tmsocyfc	119	17	al	al	NNP
cord-290566-tmsocyfc	119	18	.	.	NNP
cord-290566-tmsocyfc	119	19	,	,	,
cord-290566-tmsocyfc	119	20	2005	2005	CD
cord-290566-tmsocyfc	119	21	;	;	:
cord-290566-tmsocyfc	119	22	Vanderlugt	Vanderlugt	NNP
cord-290566-tmsocyfc	119	23	et	et	FW
cord-290566-tmsocyfc	119	24	al	al	NNP
cord-290566-tmsocyfc	119	25	.	.	NNP
cord-290566-tmsocyfc	119	26	,	,	,
cord-290566-tmsocyfc	119	27	1998	1998	CD
cord-290566-tmsocyfc	119	28	)	)	-RRB-
cord-290566-tmsocyfc	119	29	,	,	,
cord-290566-tmsocyfc	119	30	and	and	CC
cord-290566-tmsocyfc	119	31	may	may	MD
cord-290566-tmsocyfc	119	32	play	play	VB
cord-290566-tmsocyfc	119	33	an	an	DT
cord-290566-tmsocyfc	119	34	important	important	JJ
cord-290566-tmsocyfc	119	35	role	role	NN
cord-290566-tmsocyfc	119	36	in	in	IN
cord-290566-tmsocyfc	119	37	the	the	DT
cord-290566-tmsocyfc	119	38	pathogenesis	pathogenesis	NN
cord-290566-tmsocyfc	119	39	of	of	IN
cord-290566-tmsocyfc	119	40	the	the	DT
cord-290566-tmsocyfc	119	41	human	human	JJ
cord-290566-tmsocyfc	119	42	disease	disease	NN
cord-290566-tmsocyfc	119	43	.	.	.
cord-290566-tmsocyfc	120	1	Although	although	IN
cord-290566-tmsocyfc	120	2	this	this	DT
cord-290566-tmsocyfc	120	3	is	be	VBZ
cord-290566-tmsocyfc	120	4	the	the	DT
cord-290566-tmsocyfc	120	5	most	most	RBS
cord-290566-tmsocyfc	120	6	widely	widely	RB
cord-290566-tmsocyfc	120	7	accepted	accept	VBN
cord-290566-tmsocyfc	120	8	paradigm	paradigm	NN
cord-290566-tmsocyfc	120	9	of	of	IN
cord-290566-tmsocyfc	120	10	MS	MS	NNP
cord-290566-tmsocyfc	120	11	pathogenesis	pathogenesis	NN
cord-290566-tmsocyfc	120	12	,	,	,
cord-290566-tmsocyfc	120	13	and	and	CC
cord-290566-tmsocyfc	120	14	is	be	VBZ
cord-290566-tmsocyfc	120	15	supported	support	VBN
cord-290566-tmsocyfc	120	16	by	by	IN
cord-290566-tmsocyfc	120	17	evidence	evidence	NN
cord-290566-tmsocyfc	120	18	from	from	IN
cord-290566-tmsocyfc	120	19	studies	study	NNS
cord-290566-tmsocyfc	120	20	discussed	discuss	VBN
cord-290566-tmsocyfc	120	21	in	in	IN
cord-290566-tmsocyfc	120	22	this	this	DT
cord-290566-tmsocyfc	120	23	chapter	chapter	NN
cord-290566-tmsocyfc	120	24	,	,	,
cord-290566-tmsocyfc	120	25	there	there	EX
cord-290566-tmsocyfc	120	26	still	still	RB
cord-290566-tmsocyfc	120	27	remain	remain	VBP
cord-290566-tmsocyfc	120	28	many	many	JJ
cord-290566-tmsocyfc	120	29	unanswered	unanswered	JJ
cord-290566-tmsocyfc	120	30	questions	question	NNS
cord-290566-tmsocyfc	120	31	,	,	,
cord-290566-tmsocyfc	120	32	which	which	WDT
cord-290566-tmsocyfc	120	33	include	include	VBP
cord-290566-tmsocyfc	120	34	the	the	DT
cord-290566-tmsocyfc	120	35	identity	identity	NN
cord-290566-tmsocyfc	120	36	of	of	IN
cord-290566-tmsocyfc	120	37	the	the	DT
cord-290566-tmsocyfc	120	38	initiating	initiate	VBG
cord-290566-tmsocyfc	120	39	foreign	foreign	JJ
cord-290566-tmsocyfc	120	40	cross	cross	JJ
cord-290566-tmsocyfc	120	41	-	-	JJ
cord-290566-tmsocyfc	120	42	reactive	reactive	JJ
cord-290566-tmsocyfc	120	43	antigen(s	antigen(s	NNP
cord-290566-tmsocyfc	120	44	)	)	-RRB-
cord-290566-tmsocyfc	120	45	,	,	,
cord-290566-tmsocyfc	120	46	the	the	DT
cord-290566-tmsocyfc	120	47	identity	identity	NN
cord-290566-tmsocyfc	120	48	of	of	IN
cord-290566-tmsocyfc	120	49	the	the	DT
cord-290566-tmsocyfc	120	50	initiating	initiate	VBG
cord-290566-tmsocyfc	120	51	self	self	NN
cord-290566-tmsocyfc	120	52	-	-	HYPH
cord-290566-tmsocyfc	120	53	antigen	antigen	NN
cord-290566-tmsocyfc	120	54	directed	direct	VBD
cord-290566-tmsocyfc	120	55	T	t	NN
cord-290566-tmsocyfc	120	56	-	-	HYPH
cord-290566-tmsocyfc	120	57	cell	cell	NN
cord-290566-tmsocyfc	120	58	response	response	NN
cord-290566-tmsocyfc	120	59	,	,	,
cord-290566-tmsocyfc	120	60	and	and	CC
cord-290566-tmsocyfc	120	61	the	the	DT
cord-290566-tmsocyfc	120	62	nature	nature	NN
cord-290566-tmsocyfc	120	63	of	of	IN
cord-290566-tmsocyfc	120	64	epitope	epitope	NN
cord-290566-tmsocyfc	120	65	spreading	spread	VBG
cord-290566-tmsocyfc	120	66	within	within	IN
cord-290566-tmsocyfc	120	67	the	the	DT
cord-290566-tmsocyfc	120	68	CNS	CNS	NNP
cord-290566-tmsocyfc	120	69	.	.	.
cord-290566-tmsocyfc	121	1	Moreover	moreover	RB
cord-290566-tmsocyfc	121	2	,	,	,
cord-290566-tmsocyfc	121	3	the	the	DT
cord-290566-tmsocyfc	121	4	paucity	paucity	NN
cord-290566-tmsocyfc	121	5	of	of	IN
cord-290566-tmsocyfc	121	6	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	121	7	T	T	NNP
cord-290566-tmsocyfc	121	8	cells	cell	NNS
cord-290566-tmsocyfc	121	9	in	in	IN
cord-290566-tmsocyfc	121	10	certain	certain	JJ
cord-290566-tmsocyfc	121	11	pathological	pathological	JJ
cord-290566-tmsocyfc	121	12	subtypes	subtype	NNS
cord-290566-tmsocyfc	121	13	of	of	IN
cord-290566-tmsocyfc	121	14	MS	MS	NNP
cord-290566-tmsocyfc	121	15	questions	question	NNS
cord-290566-tmsocyfc	121	16	whether	whether	IN
cord-290566-tmsocyfc	121	17	alternate	alternate	JJ
cord-290566-tmsocyfc	121	18	mechanisms	mechanism	NNS
cord-290566-tmsocyfc	121	19	may	may	MD
cord-290566-tmsocyfc	121	20	predominate	predominate	VB
cord-290566-tmsocyfc	121	21	in	in	IN
cord-290566-tmsocyfc	121	22	subsets	subset	NNS
cord-290566-tmsocyfc	121	23	of	of	IN
cord-290566-tmsocyfc	121	24	this	this	DT
cord-290566-tmsocyfc	121	25	heterogeneous	heterogeneous	JJ
cord-290566-tmsocyfc	121	26	disease	disease	NN
cord-290566-tmsocyfc	121	27	.	.	.
cord-290566-tmsocyfc	122	1	Because	because	IN
cord-290566-tmsocyfc	122	2	of	of	IN
cord-290566-tmsocyfc	122	3	the	the	DT
cord-290566-tmsocyfc	122	4	focus	focus	NN
cord-290566-tmsocyfc	122	5	on	on	IN
cord-290566-tmsocyfc	122	6	myelin	myelin	JJ
cord-290566-tmsocyfc	122	7	proteins	protein	NNS
cord-290566-tmsocyfc	122	8	and	and	CC
cord-290566-tmsocyfc	122	9	,	,	,
cord-290566-tmsocyfc	122	10	in	in	IN
cord-290566-tmsocyfc	122	11	particular	particular	JJ
cord-290566-tmsocyfc	122	12	,	,	,
cord-290566-tmsocyfc	122	13	MBP	MBP	NNP
cord-290566-tmsocyfc	122	14	as	as	IN
cord-290566-tmsocyfc	122	15	a	a	DT
cord-290566-tmsocyfc	122	16	potential	potential	JJ
cord-290566-tmsocyfc	122	17	autoantigen	autoantigen	NN
cord-290566-tmsocyfc	122	18	in	in	IN
cord-290566-tmsocyfc	122	19	MS	MS	NNP
cord-290566-tmsocyfc	122	20	(	(	-LRB-
cord-290566-tmsocyfc	122	21	Allegretta	Allegretta	NNP
cord-290566-tmsocyfc	122	22	et	et	NNP
cord-290566-tmsocyfc	122	23	al	al	NNP
cord-290566-tmsocyfc	122	24	.	.	NNP
cord-290566-tmsocyfc	122	25	,	,	,
cord-290566-tmsocyfc	122	26	1990	1990	CD
cord-290566-tmsocyfc	122	27	;	;	:
cord-290566-tmsocyfc	122	28	Chou	Chou	NNP
cord-290566-tmsocyfc	122	29	et	et	NNP
cord-290566-tmsocyfc	122	30	al	al	NNP
cord-290566-tmsocyfc	122	31	.	.	NNP
cord-290566-tmsocyfc	122	32	,	,	,
cord-290566-tmsocyfc	122	33	1992	1992	CD
cord-290566-tmsocyfc	122	34	;	;	:
cord-290566-tmsocyfc	122	35	Zhang	Zhang	NNP
cord-290566-tmsocyfc	122	36	et	et	NNP
cord-290566-tmsocyfc	122	37	al	al	NNP
cord-290566-tmsocyfc	122	38	.	.	NNP
cord-290566-tmsocyfc	122	39	,	,	,
cord-290566-tmsocyfc	122	40	1994	1994	CD
cord-290566-tmsocyfc	122	41	)	)	-RRB-
cord-290566-tmsocyfc	122	42	,	,	,
cord-290566-tmsocyfc	122	43	considerable	considerable	JJ
cord-290566-tmsocyfc	122	44	interest	interest	NN
cord-290566-tmsocyfc	122	45	has	have	VBZ
cord-290566-tmsocyfc	122	46	developed	develop	VBN
cord-290566-tmsocyfc	122	47	in	in	IN
cord-290566-tmsocyfc	122	48	the	the	DT
cord-290566-tmsocyfc	122	49	role	role	NN
cord-290566-tmsocyfc	122	50	of	of	IN
cord-290566-tmsocyfc	122	51	T	t	NN
cord-290566-tmsocyfc	122	52	-	-	HYPH
cord-290566-tmsocyfc	122	53	cell	cell	NN
cord-290566-tmsocyfc	122	54	responses	response	NNS
cord-290566-tmsocyfc	122	55	to	to	IN
cord-290566-tmsocyfc	122	56	MBP	MBP	NNP
cord-290566-tmsocyfc	122	57	.	.	.
cord-290566-tmsocyfc	123	1	Moreover	moreover	RB
cord-290566-tmsocyfc	123	2	,	,	,
cord-290566-tmsocyfc	123	3	MS	MS	NNP
cord-290566-tmsocyfc	123	4	disease	disease	NN
cord-290566-tmsocyfc	123	5	-	-	HYPH
cord-290566-tmsocyfc	123	6	associated	associate	VBN
cord-290566-tmsocyfc	123	7	MHC	MHC	NNP
cord-290566-tmsocyfc	123	8	class	class	NN
cord-290566-tmsocyfc	123	9	II	II	NNP
cord-290566-tmsocyfc	123	10	allele	allele	NN
cord-290566-tmsocyfc	123	11	,	,	,
cord-290566-tmsocyfc	123	12	DRB1	DRB1	NNP
cord-290566-tmsocyfc	123	13	*	*	NFP
cord-290566-tmsocyfc	123	14	1501	1501	CD
cord-290566-tmsocyfc	123	15	has	have	VBZ
cord-290566-tmsocyfc	123	16	been	be	VBN
cord-290566-tmsocyfc	123	17	shown	show	VBN
cord-290566-tmsocyfc	123	18	to	to	TO
cord-290566-tmsocyfc	123	19	be	be	VB
cord-290566-tmsocyfc	123	20	eVective	eVective	NNP
cord-290566-tmsocyfc	123	21	in	in	IN
cord-290566-tmsocyfc	123	22	presenting	present	VBG
cord-290566-tmsocyfc	123	23	MBP	MBP	NNP
cord-290566-tmsocyfc	123	24	peptide	peptide	NN
cord-290566-tmsocyfc	123	25	to	to	IN
cord-290566-tmsocyfc	123	26	T	t	NN
cord-290566-tmsocyfc	123	27	-	-	HYPH
cord-290566-tmsocyfc	123	28	cell	cell	NN
cord-290566-tmsocyfc	123	29	clones	clone	NNS
cord-290566-tmsocyfc	123	30	isolated	isolate	VBN
cord-290566-tmsocyfc	123	31	from	from	IN
cord-290566-tmsocyfc	123	32	MS	MS	NNP
cord-290566-tmsocyfc	123	33	patients	patient	NNS
cord-290566-tmsocyfc	124	1	(	(	-LRB-
cord-290566-tmsocyfc	124	2	Wucherpfennig	Wucherpfennig	NNP
cord-290566-tmsocyfc	124	3	et	et	NNP
cord-290566-tmsocyfc	124	4	al	al	NNP
cord-290566-tmsocyfc	124	5	.	.	NNP
cord-290566-tmsocyfc	124	6	,	,	,
cord-290566-tmsocyfc	124	7	1995	1995	CD
cord-290566-tmsocyfc	125	1	(	(	-LRB-
cord-290566-tmsocyfc	125	2	Wucherpfennig	Wucherpfennig	NNP
cord-290566-tmsocyfc	125	3	et	et	NNP
cord-290566-tmsocyfc	125	4	al	al	NNP
cord-290566-tmsocyfc	125	5	.	.	NNP
cord-290566-tmsocyfc	125	6	,	,	,
cord-290566-tmsocyfc	125	7	,	,	,
cord-290566-tmsocyfc	125	8	1997	1997	CD
cord-290566-tmsocyfc	125	9	.	.	.
cord-290566-tmsocyfc	126	1	Activated	activate	VBN
cord-290566-tmsocyfc	126	2	myelin	myelin	NN
cord-290566-tmsocyfc	126	3	-	-	HYPH
cord-290566-tmsocyfc	126	4	reactive	reactive	JJ
cord-290566-tmsocyfc	126	5	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	126	6	T	T	NNP
cord-290566-tmsocyfc	126	7	cells	cell	NNS
cord-290566-tmsocyfc	126	8	50	50	CD
cord-290566-tmsocyfc	126	9	are	be	VBP
cord-290566-tmsocyfc	126	10	present	present	JJ
cord-290566-tmsocyfc	126	11	in	in	IN
cord-290566-tmsocyfc	126	12	the	the	DT
cord-290566-tmsocyfc	126	13	blood	blood	NN
cord-290566-tmsocyfc	126	14	and	and	CC
cord-290566-tmsocyfc	126	15	CSF	CSF	NNP
cord-290566-tmsocyfc	126	16	of	of	IN
cord-290566-tmsocyfc	126	17	MS	MS	NNP
cord-290566-tmsocyfc	126	18	patients	patient	NNS
cord-290566-tmsocyfc	126	19	;	;	:
cord-290566-tmsocyfc	126	20	in	in	IN
cord-290566-tmsocyfc	126	21	contrast	contrast	NN
cord-290566-tmsocyfc	126	22	,	,	,
cord-290566-tmsocyfc	126	23	only	only	RB
cord-290566-tmsocyfc	126	24	nonactivated	nonactivated	JJ
cord-290566-tmsocyfc	126	25	myelin	myelin	NN
cord-290566-tmsocyfc	126	26	-	-	HYPH
cord-290566-tmsocyfc	126	27	reactive	reactive	JJ
cord-290566-tmsocyfc	126	28	T	t	NN
cord-290566-tmsocyfc	126	29	cells	cell	NNS
cord-290566-tmsocyfc	126	30	are	be	VBP
cord-290566-tmsocyfc	126	31	present	present	JJ
cord-290566-tmsocyfc	126	32	in	in	IN
cord-290566-tmsocyfc	126	33	the	the	DT
cord-290566-tmsocyfc	126	34	blood	blood	NN
cord-290566-tmsocyfc	126	35	of	of	IN
cord-290566-tmsocyfc	126	36	controls	control	NNS
cord-290566-tmsocyfc	127	1	(	(	-LRB-
cord-290566-tmsocyfc	127	2	Zhang	Zhang	NNP
cord-290566-tmsocyfc	127	3	et	et	NNP
cord-290566-tmsocyfc	127	4	al	al	NNP
cord-290566-tmsocyfc	127	5	.	.	NNP
cord-290566-tmsocyfc	127	6	,	,	,
cord-290566-tmsocyfc	127	7	1994	1994	CD
cord-290566-tmsocyfc	127	8	)	)	-RRB-
cord-290566-tmsocyfc	127	9	.	.	.
cord-290566-tmsocyfc	128	1	Furthermore	furthermore	RB
cord-290566-tmsocyfc	128	2	,	,	,
cord-290566-tmsocyfc	128	3	MBP	MBP	NNP
cord-290566-tmsocyfc	128	4	-	-	HYPH
cord-290566-tmsocyfc	128	5	reactive	reactive	JJ
cord-290566-tmsocyfc	128	6	T	t	NN
cord-290566-tmsocyfc	128	7	cells	cell	NNS
cord-290566-tmsocyfc	128	8	isolated	isolate	VBN
cord-290566-tmsocyfc	128	9	from	from	IN
cord-290566-tmsocyfc	128	10	the	the	DT
cord-290566-tmsocyfc	128	11	CSF	CSF	NNP
cord-290566-tmsocyfc	128	12	of	of	IN
cord-290566-tmsocyfc	128	13	MS	MS	NNP
cord-290566-tmsocyfc	128	14	patients	patient	NNS
cord-290566-tmsocyfc	128	15	display	display	VBP
cord-290566-tmsocyfc	128	16	increased	increase	VBN
cord-290566-tmsocyfc	128	17	expression	expression	NN
cord-290566-tmsocyfc	128	18	of	of	IN
cord-290566-tmsocyfc	128	19	the	the	DT
cord-290566-tmsocyfc	128	20	IL-2	IL-2	NNP
cord-290566-tmsocyfc	128	21	receptor	receptor	NN
cord-290566-tmsocyfc	128	22	(	(	-LRB-
cord-290566-tmsocyfc	128	23	Zhang	Zhang	NNP
cord-290566-tmsocyfc	128	24	et	et	NNP
cord-290566-tmsocyfc	128	25	al	al	NNP
cord-290566-tmsocyfc	128	26	.	.	NNP
cord-290566-tmsocyfc	128	27	,	,	,
cord-290566-tmsocyfc	128	28	1994	1994	CD
cord-290566-tmsocyfc	128	29	)	)	-RRB-
cord-290566-tmsocyfc	128	30	,	,	,
cord-290566-tmsocyfc	128	31	consistent	consistent	JJ
cord-290566-tmsocyfc	128	32	with	with	IN
cord-290566-tmsocyfc	128	33	a	a	DT
cord-290566-tmsocyfc	128	34	previously	previously	RB
cord-290566-tmsocyfc	128	35	activated	activate	VBN
cord-290566-tmsocyfc	128	36	or	or	CC
cord-290566-tmsocyfc	128	37	memory	memory	NN
cord-290566-tmsocyfc	128	38	phenotype	phenotype	NN
cord-290566-tmsocyfc	128	39	.	.	.
cord-290566-tmsocyfc	129	1	In	in	IN
cord-290566-tmsocyfc	129	2	MS	MS	NNP
cord-290566-tmsocyfc	129	3	patients	patient	NNS
cord-290566-tmsocyfc	129	4	,	,	,
cord-290566-tmsocyfc	129	5	but	but	CC
cord-290566-tmsocyfc	129	6	not	not	RB
cord-290566-tmsocyfc	129	7	in	in	IN
cord-290566-tmsocyfc	129	8	healthy	healthy	JJ
cord-290566-tmsocyfc	129	9	controls	control	NNS
cord-290566-tmsocyfc	129	10	,	,	,
cord-290566-tmsocyfc	129	11	these	these	DT
cord-290566-tmsocyfc	129	12	cells	cell	NNS
cord-290566-tmsocyfc	129	13	can	can	MD
cord-290566-tmsocyfc	129	14	be	be	VB
cord-290566-tmsocyfc	129	15	activated	activate	VBN
cord-290566-tmsocyfc	129	16	in	in	IN
cord-290566-tmsocyfc	129	17	the	the	DT
cord-290566-tmsocyfc	129	18	absence	absence	NN
cord-290566-tmsocyfc	129	19	of	of	IN
cord-290566-tmsocyfc	129	20	CD28-B7	CD28-B7	NNP
cord-290566-tmsocyfc	129	21	costimulation	costimulation	NN
cord-290566-tmsocyfc	129	22	,	,	,
cord-290566-tmsocyfc	129	23	thus	thus	RB
cord-290566-tmsocyfc	129	24	implying	imply	VBG
cord-290566-tmsocyfc	129	25	that	that	IN
cord-290566-tmsocyfc	129	26	they	-PRON-	PRP
cord-290566-tmsocyfc	129	27	have	have	VBP
cord-290566-tmsocyfc	129	28	been	be	VBN
cord-290566-tmsocyfc	129	29	previously	previously	RB
cord-290566-tmsocyfc	129	30	activated	activate	VBN
cord-290566-tmsocyfc	129	31	in	in	IN
cord-290566-tmsocyfc	129	32	vivo	vivo	NN
cord-290566-tmsocyfc	130	1	(	(	-LRB-
cord-290566-tmsocyfc	130	2	Markovic	Markovic	NNP
cord-290566-tmsocyfc	130	3	-	-	HYPH
cord-290566-tmsocyfc	130	4	Plese	Plese	NNP
cord-290566-tmsocyfc	130	5	et	et	NNP
cord-290566-tmsocyfc	130	6	al	al	NNP
cord-290566-tmsocyfc	130	7	.	.	NNP
cord-290566-tmsocyfc	130	8	,	,	,
cord-290566-tmsocyfc	130	9	2001	2001	CD
cord-290566-tmsocyfc	131	1	;	;	:
cord-290566-tmsocyfc	131	2	Scholz	Scholz	NNP
cord-290566-tmsocyfc	131	3	et	et	FW
cord-290566-tmsocyfc	131	4	al	al	NNP
cord-290566-tmsocyfc	131	5	.	.	NNP
cord-290566-tmsocyfc	131	6	,	,	,
cord-290566-tmsocyfc	131	7	1998	1998	CD
cord-290566-tmsocyfc	131	8	)	)	-RRB-
cord-290566-tmsocyfc	131	9	.	.	.
cord-290566-tmsocyfc	132	1	MBP	MBP	NNP
cord-290566-tmsocyfc	132	2	-	-	HYPH
cord-290566-tmsocyfc	132	3	reactive	reactive	JJ
cord-290566-tmsocyfc	132	4	T	t	NN
cord-290566-tmsocyfc	132	5	cells	cell	NNS
cord-290566-tmsocyfc	132	6	from	from	IN
cord-290566-tmsocyfc	132	7	MS	MS	NNP
cord-290566-tmsocyfc	132	8	patients	patient	NNS
cord-290566-tmsocyfc	132	9	were	be	VBD
cord-290566-tmsocyfc	132	10	found	find	VBN
cord-290566-tmsocyfc	132	11	to	to	TO
cord-290566-tmsocyfc	132	12	be	be	VB
cord-290566-tmsocyfc	132	13	less	less	RBR
cord-290566-tmsocyfc	132	14	responsive	responsive	JJ
cord-290566-tmsocyfc	132	15	to	to	IN
cord-290566-tmsocyfc	132	16	CTLA-4	CTLA-4	NNS
cord-290566-tmsocyfc	132	17	blockade	blockade	VB
cord-290566-tmsocyfc	132	18	compared	compare	VBN
cord-290566-tmsocyfc	132	19	to	to	IN
cord-290566-tmsocyfc	132	20	those	those	DT
cord-290566-tmsocyfc	132	21	from	from	IN
cord-290566-tmsocyfc	132	22	healthy	healthy	JJ
cord-290566-tmsocyfc	132	23	controls	control	NNS
cord-290566-tmsocyfc	132	24	(	(	-LRB-
cord-290566-tmsocyfc	132	25	Oliveira	Oliveira	NNP
cord-290566-tmsocyfc	132	26	et	et	NNP
cord-290566-tmsocyfc	132	27	al	al	NNP
cord-290566-tmsocyfc	132	28	.	.	NNP
cord-290566-tmsocyfc	132	29	,	,	,
cord-290566-tmsocyfc	132	30	2003	2003	CD
cord-290566-tmsocyfc	132	31	)	)	-RRB-
cord-290566-tmsocyfc	132	32	,	,	,
cord-290566-tmsocyfc	132	33	signifying	signify	VBG
cord-290566-tmsocyfc	132	34	that	that	IN
cord-290566-tmsocyfc	132	35	in	in	IN
cord-290566-tmsocyfc	132	36	MS	MS	NNP
cord-290566-tmsocyfc	132	37	patients	patient	NNS
cord-290566-tmsocyfc	132	38	these	these	DT
cord-290566-tmsocyfc	132	39	T	t	NN
cord-290566-tmsocyfc	132	40	cells	cell	NNS
cord-290566-tmsocyfc	132	41	are	be	VBP
cord-290566-tmsocyfc	132	42	not	not	RB
cord-290566-tmsocyfc	132	43	subject	subject	JJ
cord-290566-tmsocyfc	132	44	to	to	IN
cord-290566-tmsocyfc	132	45	the	the	DT
cord-290566-tmsocyfc	132	46	normal	normal	JJ
cord-290566-tmsocyfc	132	47	regulatory	regulatory	JJ
cord-290566-tmsocyfc	132	48	mechanisms	mechanism	NNS
cord-290566-tmsocyfc	132	49	.	.	.
cord-290566-tmsocyfc	133	1	Although	although	IN
cord-290566-tmsocyfc	133	2	the	the	DT
cord-290566-tmsocyfc	133	3	contribution	contribution	NN
cord-290566-tmsocyfc	133	4	of	of	IN
cord-290566-tmsocyfc	133	5	MBP	MBP	NNP
cord-290566-tmsocyfc	133	6	-	-	HYPH
cord-290566-tmsocyfc	133	7	reactive	reactive	JJ
cord-290566-tmsocyfc	133	8	T	t	NN
cord-290566-tmsocyfc	133	9	cells	cell	NNS
cord-290566-tmsocyfc	133	10	to	to	IN
cord-290566-tmsocyfc	133	11	the	the	DT
cord-290566-tmsocyfc	133	12	pathogenesis	pathogenesis	NN
cord-290566-tmsocyfc	133	13	of	of	IN
cord-290566-tmsocyfc	133	14	MS	MS	NNP
cord-290566-tmsocyfc	133	15	is	be	VBZ
cord-290566-tmsocyfc	133	16	currently	currently	RB
cord-290566-tmsocyfc	133	17	unknown	unknown	JJ
cord-290566-tmsocyfc	133	18	,	,	,
cord-290566-tmsocyfc	133	19	their	-PRON-	PRP$
cord-290566-tmsocyfc	133	20	diVerential	diverential	JJ
cord-290566-tmsocyfc	133	21	phenotype	phenotype	NN
cord-290566-tmsocyfc	133	22	and	and	CC
cord-290566-tmsocyfc	133	23	costimulatory	costimulatory	NN
cord-290566-tmsocyfc	133	24	requirements	requirement	NNS
cord-290566-tmsocyfc	133	25	indicate	indicate	VBP
cord-290566-tmsocyfc	133	26	a	a	DT
cord-290566-tmsocyfc	133	27	memory	memory	NN
cord-290566-tmsocyfc	133	28	and	and	CC
cord-290566-tmsocyfc	133	29	potentially	potentially	RB
cord-290566-tmsocyfc	133	30	dysregulated	dysregulated	JJ
cord-290566-tmsocyfc	133	31	cell	cell	NN
cord-290566-tmsocyfc	133	32	population	population	NN
cord-290566-tmsocyfc	133	33	.	.	.
cord-290566-tmsocyfc	134	1	T	t	NN
cord-290566-tmsocyfc	134	2	-	-	HYPH
cord-290566-tmsocyfc	134	3	cell	cell	NN
cord-290566-tmsocyfc	134	4	reactivity	reactivity	NN
cord-290566-tmsocyfc	134	5	to	to	IN
cord-290566-tmsocyfc	134	6	other	other	JJ
cord-290566-tmsocyfc	134	7	myelin	myelin	NN
cord-290566-tmsocyfc	134	8	proteins	protein	NNS
cord-290566-tmsocyfc	134	9	and	and	CC
cord-290566-tmsocyfc	134	10	peptides	peptide	NNS
cord-290566-tmsocyfc	134	11	in	in	IN
cord-290566-tmsocyfc	134	12	MS	MS	NNP
cord-290566-tmsocyfc	134	13	has	have	VBZ
cord-290566-tmsocyfc	134	14	been	be	VBN
cord-290566-tmsocyfc	134	15	explored	explore	VBN
cord-290566-tmsocyfc	134	16	.	.	.
cord-290566-tmsocyfc	135	1	Studies	study	NNS
cord-290566-tmsocyfc	135	2	examining	examine	VBG
cord-290566-tmsocyfc	135	3	PLP	PLP	NNP
cord-290566-tmsocyfc	135	4	T	T	NNP
cord-290566-tmsocyfc	135	5	-	-	HYPH
cord-290566-tmsocyfc	135	6	cell	cell	NN
cord-290566-tmsocyfc	135	7	responses	response	NNS
cord-290566-tmsocyfc	135	8	demonstrated	demonstrate	VBD
cord-290566-tmsocyfc	135	9	T	t	NN
cord-290566-tmsocyfc	135	10	-	-	HYPH
cord-290566-tmsocyfc	135	11	cell	cell	NN
cord-290566-tmsocyfc	135	12	proliferation	proliferation	NN
cord-290566-tmsocyfc	135	13	to	to	IN
cord-290566-tmsocyfc	135	14	certain	certain	JJ
cord-290566-tmsocyfc	135	15	epitopes	epitope	NNS
cord-290566-tmsocyfc	135	16	(	(	-LRB-
cord-290566-tmsocyfc	135	17	Pelfrey	Pelfrey	NNP
cord-290566-tmsocyfc	135	18	et	et	NNP
cord-290566-tmsocyfc	135	19	al	al	NNP
cord-290566-tmsocyfc	135	20	.	.	NNP
cord-290566-tmsocyfc	135	21	,	,	,
cord-290566-tmsocyfc	135	22	1994	1994	CD
cord-290566-tmsocyfc	135	23	)	)	-RRB-
cord-290566-tmsocyfc	135	24	,	,	,
cord-290566-tmsocyfc	135	25	with	with	IN
cord-290566-tmsocyfc	135	26	some	some	DT
cord-290566-tmsocyfc	135	27	diVerential	diverential	JJ
cord-290566-tmsocyfc	135	28	reactivity	reactivity	NN
cord-290566-tmsocyfc	135	29	when	when	WRB
cord-290566-tmsocyfc	135	30	compared	compare	VBN
cord-290566-tmsocyfc	135	31	to	to	IN
cord-290566-tmsocyfc	135	32	controls	control	NNS
cord-290566-tmsocyfc	135	33	(	(	-LRB-
cord-290566-tmsocyfc	135	34	Markovic	Markovic	NNP
cord-290566-tmsocyfc	135	35	-	-	HYPH
cord-290566-tmsocyfc	135	36	Plese	Plese	NNP
cord-290566-tmsocyfc	135	37	et	et	NNP
cord-290566-tmsocyfc	135	38	al	al	NNP
cord-290566-tmsocyfc	135	39	.	.	NNP
cord-290566-tmsocyfc	135	40	,	,	,
cord-290566-tmsocyfc	135	41	1995	1995	CD
cord-290566-tmsocyfc	135	42	;	;	:
cord-290566-tmsocyfc	135	43	Zhang	Zhang	NNP
cord-290566-tmsocyfc	135	44	et	et	NNP
cord-290566-tmsocyfc	135	45	al	al	NNP
cord-290566-tmsocyfc	135	46	.	.	NNP
cord-290566-tmsocyfc	135	47	,	,	,
cord-290566-tmsocyfc	135	48	1994	1994	CD
cord-290566-tmsocyfc	135	49	)	)	-RRB-
cord-290566-tmsocyfc	135	50	.	.	.
cord-290566-tmsocyfc	136	1	T	t	NN
cord-290566-tmsocyfc	136	2	-	-	HYPH
cord-290566-tmsocyfc	136	3	cell	cell	NN
cord-290566-tmsocyfc	136	4	responses	response	NNS
cord-290566-tmsocyfc	136	5	to	to	IN
cord-290566-tmsocyfc	136	6	recombinant	recombinant	JJ
cord-290566-tmsocyfc	136	7	MOG	MOG	NNP
cord-290566-tmsocyfc	136	8	appeared	appear	VBD
cord-290566-tmsocyfc	136	9	to	to	TO
cord-290566-tmsocyfc	136	10	be	be	VB
cord-290566-tmsocyfc	136	11	similar	similar	JJ
cord-290566-tmsocyfc	136	12	in	in	IN
cord-290566-tmsocyfc	136	13	MS	MS	NNP
cord-290566-tmsocyfc	136	14	patients	patient	NNS
cord-290566-tmsocyfc	136	15	and	and	CC
cord-290566-tmsocyfc	136	16	healthy	healthy	JJ
cord-290566-tmsocyfc	136	17	controls	control	NNS
cord-290566-tmsocyfc	136	18	(	(	-LRB-
cord-290566-tmsocyfc	136	19	Diaz	Diaz	NNP
cord-290566-tmsocyfc	136	20	-	-	HYPH
cord-290566-tmsocyfc	136	21	Villoslada	Villoslada	NNP
cord-290566-tmsocyfc	136	22	et	et	FW
cord-290566-tmsocyfc	136	23	al	al	NNP
cord-290566-tmsocyfc	136	24	.	.	NNP
cord-290566-tmsocyfc	136	25	,	,	,
cord-290566-tmsocyfc	136	26	1999	1999	CD
cord-290566-tmsocyfc	136	27	)	)	-RRB-
cord-290566-tmsocyfc	136	28	,	,	,
cord-290566-tmsocyfc	136	29	although	although	IN
cord-290566-tmsocyfc	136	30	other	other	JJ
cord-290566-tmsocyfc	136	31	studies	study	NNS
cord-290566-tmsocyfc	136	32	demonstrated	demonstrate	VBD
cord-290566-tmsocyfc	136	33	increased	increased	JJ
cord-290566-tmsocyfc	136	34	reactivity	reactivity	NN
cord-290566-tmsocyfc	136	35	(	(	-LRB-
cord-290566-tmsocyfc	136	36	Kerlero	Kerlero	NNP
cord-290566-tmsocyfc	136	37	de	de	NNP
cord-290566-tmsocyfc	136	38	Rosbo	Rosbo	NNP
cord-290566-tmsocyfc	136	39	et	et	FW
cord-290566-tmsocyfc	136	40	al	al	NNP
cord-290566-tmsocyfc	136	41	.	.	NNP
cord-290566-tmsocyfc	136	42	,	,	,
cord-290566-tmsocyfc	136	43	1993	1993	CD
cord-290566-tmsocyfc	136	44	)	)	-RRB-
cord-290566-tmsocyfc	136	45	or	or	CC
cord-290566-tmsocyfc	136	46	altered	alter	VBD
cord-290566-tmsocyfc	136	47	T	t	NN
cord-290566-tmsocyfc	136	48	-	-	HYPH
cord-290566-tmsocyfc	136	49	cell	cell	NN
cord-290566-tmsocyfc	136	50	properties	property	NNS
cord-290566-tmsocyfc	136	51	(	(	-LRB-
cord-290566-tmsocyfc	136	52	Van	Van	NNP
cord-290566-tmsocyfc	136	53	der	der	NNP
cord-290566-tmsocyfc	136	54	Aa	Aa	NNP
cord-290566-tmsocyfc	136	55	et	et	FW
cord-290566-tmsocyfc	136	56	al	al	NNP
cord-290566-tmsocyfc	136	57	.	.	NNP
cord-290566-tmsocyfc	136	58	,	,	,
cord-290566-tmsocyfc	136	59	2003a	2003a	CD
cord-290566-tmsocyfc	136	60	)	)	-RRB-
cord-290566-tmsocyfc	136	61	in	in	IN
cord-290566-tmsocyfc	136	62	MS	MS	NNP
cord-290566-tmsocyfc	136	63	patients	patient	NNS
cord-290566-tmsocyfc	136	64	.	.	.
cord-290566-tmsocyfc	137	1	Other	other	JJ
cord-290566-tmsocyfc	137	2	studies	study	NNS
cord-290566-tmsocyfc	137	3	have	have	VBP
cord-290566-tmsocyfc	137	4	examined	examine	VBN
cord-290566-tmsocyfc	137	5	T	t	NN
cord-290566-tmsocyfc	137	6	-	-	HYPH
cord-290566-tmsocyfc	137	7	cell	cell	NN
cord-290566-tmsocyfc	137	8	responses	response	NNS
cord-290566-tmsocyfc	137	9	to	to	IN
cord-290566-tmsocyfc	137	10	myelin	myelin	NN
cord-290566-tmsocyfc	137	11	oligodendrocyte	oligodendrocyte	.
cord-290566-tmsocyfc	137	12	basic	basic	JJ
cord-290566-tmsocyfc	137	13	protein	protein	NN
cord-290566-tmsocyfc	137	14	(	(	-LRB-
cord-290566-tmsocyfc	137	15	MOBP	MOBP	NNP
cord-290566-tmsocyfc	137	16	)	)	-RRB-
cord-290566-tmsocyfc	138	1	(	(	-LRB-
cord-290566-tmsocyfc	138	2	Holz	Holz	NNP
cord-290566-tmsocyfc	138	3	et	et	NNP
cord-290566-tmsocyfc	138	4	al	al	NNP
cord-290566-tmsocyfc	138	5	.	.	NNP
cord-290566-tmsocyfc	138	6	,	,	,
cord-290566-tmsocyfc	138	7	2000	2000	CD
cord-290566-tmsocyfc	138	8	)	)	-RRB-
cord-290566-tmsocyfc	138	9	or	or	CC
cord-290566-tmsocyfc	138	10	2	2	CD
cord-290566-tmsocyfc	138	11	0	0	CD
cord-290566-tmsocyfc	139	1	,	,	,
cord-290566-tmsocyfc	139	2	3	3	CD
cord-290566-tmsocyfc	139	3	0	0	CD
cord-290566-tmsocyfc	139	4	-cyclic	-cyclic	NN
cord-290566-tmsocyfc	139	5	nucleotide	nucleotide	JJ
cord-290566-tmsocyfc	139	6	3	3	CD
cord-290566-tmsocyfc	139	7	0	0	CD
cord-290566-tmsocyfc	140	1	-phosphodiesterase	-phosphodiesterase	NNP
cord-290566-tmsocyfc	141	1	(	(	-LRB-
cord-290566-tmsocyfc	141	2	CNPase	CNPase	NNP
cord-290566-tmsocyfc	141	3	)	)	-RRB-
cord-290566-tmsocyfc	142	1	(	(	-LRB-
cord-290566-tmsocyfc	142	2	Muraro	Muraro	NNP
cord-290566-tmsocyfc	142	3	et	et	NNP
cord-290566-tmsocyfc	142	4	al	al	NNP
cord-290566-tmsocyfc	142	5	.	.	NNP
cord-290566-tmsocyfc	142	6	,	,	,
cord-290566-tmsocyfc	142	7	2002	2002	CD
cord-290566-tmsocyfc	142	8	)	)	-RRB-
cord-290566-tmsocyfc	142	9	,	,	,
cord-290566-tmsocyfc	142	10	with	with	IN
cord-290566-tmsocyfc	142	11	some	some	DT
cord-290566-tmsocyfc	142	12	reactivity	reactivity	NN
cord-290566-tmsocyfc	142	13	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	142	14	in	in	IN
cord-290566-tmsocyfc	142	15	T	t	NN
cord-290566-tmsocyfc	142	16	-	-	HYPH
cord-290566-tmsocyfc	142	17	cell	cell	NN
cord-290566-tmsocyfc	142	18	lines	line	NNS
cord-290566-tmsocyfc	142	19	isolated	isolate	VBN
cord-290566-tmsocyfc	142	20	from	from	IN
cord-290566-tmsocyfc	142	21	select	select	JJ
cord-290566-tmsocyfc	142	22	MS	MS	NNP
cord-290566-tmsocyfc	142	23	patients	patient	NNS
cord-290566-tmsocyfc	142	24	.	.	.
cord-290566-tmsocyfc	143	1	T	t	NN
cord-290566-tmsocyfc	143	2	-	-	HYPH
cord-290566-tmsocyfc	143	3	cell	cell	NN
cord-290566-tmsocyfc	143	4	reactivity	reactivity	NN
cord-290566-tmsocyfc	143	5	to	to	IN
cord-290566-tmsocyfc	143	6	other	other	JJ
cord-290566-tmsocyfc	143	7	CNS	CNS	NNP
cord-290566-tmsocyfc	143	8	antigens	antigen	NNS
cord-290566-tmsocyfc	143	9	has	have	VBZ
cord-290566-tmsocyfc	143	10	not	not	RB
cord-290566-tmsocyfc	143	11	been	be	VBN
cord-290566-tmsocyfc	143	12	fully	fully	RB
cord-290566-tmsocyfc	143	13	explored	explore	VBN
cord-290566-tmsocyfc	143	14	due	due	IN
cord-290566-tmsocyfc	143	15	to	to	IN
cord-290566-tmsocyfc	143	16	the	the	DT
cord-290566-tmsocyfc	143	17	technical	technical	JJ
cord-290566-tmsocyfc	143	18	diYculties	diYculties	NNP
cord-290566-tmsocyfc	143	19	with	with	IN
cord-290566-tmsocyfc	143	20	performing	perform	VBG
cord-290566-tmsocyfc	143	21	and	and	CC
cord-290566-tmsocyfc	143	22	interpreting	interpret	VBG
cord-290566-tmsocyfc	143	23	the	the	DT
cord-290566-tmsocyfc	143	24	results	result	NNS
cord-290566-tmsocyfc	143	25	of	of	IN
cord-290566-tmsocyfc	143	26	such	such	JJ
cord-290566-tmsocyfc	143	27	assays	assay	NNS
cord-290566-tmsocyfc	143	28	.	.	.
cord-290566-tmsocyfc	144	1	Many	many	JJ
cord-290566-tmsocyfc	144	2	studies	study	NNS
cord-290566-tmsocyfc	144	3	currently	currently	RB
cord-290566-tmsocyfc	144	4	employ	employ	VBP
cord-290566-tmsocyfc	144	5	strategies	strategy	NNS
cord-290566-tmsocyfc	144	6	to	to	TO
cord-290566-tmsocyfc	144	7	expand	expand	VB
cord-290566-tmsocyfc	144	8	T	t	NN
cord-290566-tmsocyfc	144	9	cells	cell	NNS
cord-290566-tmsocyfc	144	10	using	use	VBG
cord-290566-tmsocyfc	144	11	nonspecific	nonspecific	JJ
cord-290566-tmsocyfc	144	12	methods	method	NNS
cord-290566-tmsocyfc	144	13	or	or	CC
cord-290566-tmsocyfc	144	14	mixtures	mixture	NNS
cord-290566-tmsocyfc	144	15	of	of	IN
cord-290566-tmsocyfc	144	16	myelin	myelin	NN
cord-290566-tmsocyfc	144	17	peptides	peptide	NNS
cord-290566-tmsocyfc	144	18	.	.	.
cord-290566-tmsocyfc	145	1	Studies	study	NNS
cord-290566-tmsocyfc	145	2	in	in	IN
cord-290566-tmsocyfc	145	3	patients	patient	NNS
cord-290566-tmsocyfc	145	4	with	with	IN
cord-290566-tmsocyfc	145	5	postinfectious	postinfectious	NNP
cord-290566-tmsocyfc	145	6	encephalomyelitis	encephalomyelitis	NN
cord-290566-tmsocyfc	145	7	or	or	CC
cord-290566-tmsocyfc	145	8	acute	acute	JJ
cord-290566-tmsocyfc	145	9	disseminated	disseminate	VBN
cord-290566-tmsocyfc	145	10	encephalomyelitis	encephalomyelitis	NN
cord-290566-tmsocyfc	145	11	(	(	-LRB-
cord-290566-tmsocyfc	145	12	ADEM	ADEM	NNP
cord-290566-tmsocyfc	145	13	)	)	-RRB-
cord-290566-tmsocyfc	145	14	have	have	VBP
cord-290566-tmsocyfc	145	15	consistently	consistently	RB
cord-290566-tmsocyfc	145	16	found	find	VBN
cord-290566-tmsocyfc	145	17	robust	robust	JJ
cord-290566-tmsocyfc	145	18	T	t	NN
cord-290566-tmsocyfc	145	19	-	-	HYPH
cord-290566-tmsocyfc	145	20	cell	cell	NN
cord-290566-tmsocyfc	145	21	reactivity	reactivity	NN
cord-290566-tmsocyfc	145	22	to	to	IN
cord-290566-tmsocyfc	145	23	myelin	myelin	NN
cord-290566-tmsocyfc	145	24	peptides	peptide	NNS
cord-290566-tmsocyfc	145	25	in	in	IN
cord-290566-tmsocyfc	145	26	both	both	CC
cord-290566-tmsocyfc	145	27	the	the	DT
cord-290566-tmsocyfc	145	28	blood	blood	NN
cord-290566-tmsocyfc	145	29	and	and	CC
cord-290566-tmsocyfc	145	30	CSF	CSF	NNP
cord-290566-tmsocyfc	145	31	(	(	-LRB-
cord-290566-tmsocyfc	145	32	Hafler	Hafler	NNP
cord-290566-tmsocyfc	145	33	et	et	NNP
cord-290566-tmsocyfc	145	34	al	al	NNP
cord-290566-tmsocyfc	145	35	.	.	NNP
cord-290566-tmsocyfc	145	36	,	,	,
cord-290566-tmsocyfc	145	37	1987	1987	CD
cord-290566-tmsocyfc	145	38	;	;	.
cord-290566-tmsocyfc	146	1	Hemachudha	Hemachudha	NNP
cord-290566-tmsocyfc	146	2	et	et	NNP
cord-290566-tmsocyfc	146	3	al	al	NNP
cord-290566-tmsocyfc	146	4	.	.	NNP
cord-290566-tmsocyfc	146	5	,	,	,
cord-290566-tmsocyfc	146	6	1988	1988	CD
cord-290566-tmsocyfc	146	7	;	;	:
cord-290566-tmsocyfc	146	8	Pohl	Pohl	NNP
cord-290566-tmsocyfc	146	9	-	-	HYPH
cord-290566-tmsocyfc	146	10	Koppe	Koppe	NNP
cord-290566-tmsocyfc	146	11	et	et	NNP
cord-290566-tmsocyfc	146	12	al	al	NNP
cord-290566-tmsocyfc	146	13	.	.	NNP
cord-290566-tmsocyfc	146	14	,	,	,
cord-290566-tmsocyfc	146	15	1998	1998	CD
cord-290566-tmsocyfc	146	16	)	)	-RRB-
cord-290566-tmsocyfc	146	17	,	,	,
cord-290566-tmsocyfc	146	18	and	and	CC
cord-290566-tmsocyfc	146	19	suggest	suggest	VBP
cord-290566-tmsocyfc	146	20	an	an	DT
cord-290566-tmsocyfc	146	21	intriguing	intriguing	JJ
cord-290566-tmsocyfc	146	22	relationship	relationship	NN
cord-290566-tmsocyfc	146	23	in	in	IN
cord-290566-tmsocyfc	146	24	the	the	DT
cord-290566-tmsocyfc	146	25	pathophysiology	pathophysiology	NN
cord-290566-tmsocyfc	146	26	of	of	IN
cord-290566-tmsocyfc	146	27	ADEM	ADEM	NNP
cord-290566-tmsocyfc	146	28	and	and	CC
cord-290566-tmsocyfc	146	29	MS	MS	NNP
cord-290566-tmsocyfc	146	30	.	.	.
cord-290566-tmsocyfc	147	1	Studies	study	NNS
cord-290566-tmsocyfc	147	2	examining	examine	VBG
cord-290566-tmsocyfc	147	3	TCR	TCR	NNP
cord-290566-tmsocyfc	147	4	repertoire	repertoire	NN
cord-290566-tmsocyfc	147	5	in	in	IN
cord-290566-tmsocyfc	147	6	MS	MS	NNP
cord-290566-tmsocyfc	147	7	patients	patient	NNS
cord-290566-tmsocyfc	147	8	have	have	VBP
cord-290566-tmsocyfc	147	9	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	147	10	a	a	DT
cord-290566-tmsocyfc	147	11	bias	bias	NN
cord-290566-tmsocyfc	147	12	for	for	IN
cord-290566-tmsocyfc	147	13	use	use	NN
cord-290566-tmsocyfc	147	14	of	of	IN
cord-290566-tmsocyfc	147	15	chain	chain	NN
cord-290566-tmsocyfc	147	16	variable	variable	NN
cord-290566-tmsocyfc	147	17	region	region	NN
cord-290566-tmsocyfc	147	18	(	(	-LRB-
cord-290566-tmsocyfc	147	19	V	v	NN
cord-290566-tmsocyfc	147	20	)	)	-RRB-
cord-290566-tmsocyfc	147	21	5.2	5.2	CD
cord-290566-tmsocyfc	147	22	and	and	CC
cord-290566-tmsocyfc	147	23	5.3	5.3	CD
cord-290566-tmsocyfc	147	24	(	(	-LRB-
cord-290566-tmsocyfc	147	25	Kotzin	Kotzin	NNP
cord-290566-tmsocyfc	147	26	et	et	NNP
cord-290566-tmsocyfc	147	27	al	al	NNP
cord-290566-tmsocyfc	147	28	.	.	NNP
cord-290566-tmsocyfc	147	29	,	,	,
cord-290566-tmsocyfc	147	30	1991	1991	CD
cord-290566-tmsocyfc	147	31	;	;	:
cord-290566-tmsocyfc	147	32	Lozeron	Lozeron	NNP
cord-290566-tmsocyfc	147	33	et	et	FW
cord-290566-tmsocyfc	147	34	al	al	NNP
cord-290566-tmsocyfc	147	35	.	.	NNP
cord-290566-tmsocyfc	147	36	,	,	,
cord-290566-tmsocyfc	147	37	1998	1998	CD
cord-290566-tmsocyfc	147	38	;	;	:
cord-290566-tmsocyfc	147	39	Oksenberg	Oksenberg	NNP
cord-290566-tmsocyfc	147	40	et	et	NNP
cord-290566-tmsocyfc	147	41	al	al	NNP
cord-290566-tmsocyfc	147	42	.	.	NNP
cord-290566-tmsocyfc	147	43	,	,	,
cord-290566-tmsocyfc	147	44	1993	1993	CD
cord-290566-tmsocyfc	147	45	)	)	-RRB-
cord-290566-tmsocyfc	147	46	,	,	,
cord-290566-tmsocyfc	147	47	and	and	CC
cord-290566-tmsocyfc	147	48	this	this	DT
cord-290566-tmsocyfc	147	49	has	have	VBZ
cord-290566-tmsocyfc	147	50	led	lead	VBN
cord-290566-tmsocyfc	147	51	to	to	IN
cord-290566-tmsocyfc	147	52	the	the	DT
cord-290566-tmsocyfc	147	53	exploration	exploration	NN
cord-290566-tmsocyfc	147	54	of	of	IN
cord-290566-tmsocyfc	147	55	TCR	TCR	NNP
cord-290566-tmsocyfc	147	56	V	V	NNP
cord-290566-tmsocyfc	147	57	5.2/5.3-targeted	5.2/5.3-targeted	CD
cord-290566-tmsocyfc	147	58	therapies	therapy	NNS
cord-290566-tmsocyfc	147	59	.	.	.
cord-290566-tmsocyfc	148	1	TCR	TCR	NNP
cord-290566-tmsocyfc	148	2	vaccines	vaccine	NNS
cord-290566-tmsocyfc	148	3	employing	employ	VBG
cord-290566-tmsocyfc	148	4	TCR	TCR	NNP
cord-290566-tmsocyfc	148	5	V	V	NNP
cord-290566-tmsocyfc	148	6	5.2	5.2	CD
cord-290566-tmsocyfc	148	7	peptides	peptide	NNS
cord-290566-tmsocyfc	148	8	are	be	VBP
cord-290566-tmsocyfc	148	9	THE	the	DT
cord-290566-tmsocyfc	148	10	ROLE	role	NN
cord-290566-tmsocyfc	148	11	OF	of	IN
cord-290566-tmsocyfc	148	12	CD4	CD4	NNP
cord-290566-tmsocyfc	148	13	T	T	NNP
cord-290566-tmsocyfc	148	14	CELLS	cell	VBN
cord-290566-tmsocyfc	148	15	IN	in	IN
cord-290566-tmsocyfc	148	16	THE	the	DT
cord-290566-tmsocyfc	148	17	PATHOGENESIS	PATHOGENESIS	NNP
cord-290566-tmsocyfc	148	18	thought	think	VBD
cord-290566-tmsocyfc	148	19	to	to	TO
cord-290566-tmsocyfc	148	20	exert	exert	VB
cord-290566-tmsocyfc	148	21	their	-PRON-	PRP$
cord-290566-tmsocyfc	148	22	eVects	evect	NNS
cord-290566-tmsocyfc	148	23	by	by	IN
cord-290566-tmsocyfc	148	24	enhancing	enhance	VBG
cord-290566-tmsocyfc	148	25	the	the	DT
cord-290566-tmsocyfc	148	26	function	function	NN
cord-290566-tmsocyfc	148	27	of	of	IN
cord-290566-tmsocyfc	148	28	regulatory	regulatory	JJ
cord-290566-tmsocyfc	148	29	T	t	NN
cord-290566-tmsocyfc	148	30	-	-	HYPH
cord-290566-tmsocyfc	148	31	cell	cell	NN
cord-290566-tmsocyfc	148	32	populations	population	NNS
cord-290566-tmsocyfc	148	33	recognizing	recognize	VBG
cord-290566-tmsocyfc	148	34	TCR	TCR	NNP
cord-290566-tmsocyfc	148	35	determinants	determinant	NNS
cord-290566-tmsocyfc	148	36	(	(	-LRB-
cord-290566-tmsocyfc	148	37	Vandenbark	Vandenbark	NNP
cord-290566-tmsocyfc	148	38	,	,	,
cord-290566-tmsocyfc	148	39	2005	2005	CD
cord-290566-tmsocyfc	148	40	;	;	:
cord-290566-tmsocyfc	148	41	Vandenbark	Vandenbark	NNP
cord-290566-tmsocyfc	148	42	et	et	NNP
cord-290566-tmsocyfc	148	43	al	al	NNP
cord-290566-tmsocyfc	148	44	.	.	NNP
cord-290566-tmsocyfc	148	45	,	,	,
cord-290566-tmsocyfc	148	46	1996	1996	CD
cord-290566-tmsocyfc	148	47	)	)	-RRB-
cord-290566-tmsocyfc	148	48	,	,	,
cord-290566-tmsocyfc	148	49	and	and	CC
cord-290566-tmsocyfc	148	50	are	be	VBP
cord-290566-tmsocyfc	148	51	currently	currently	RB
cord-290566-tmsocyfc	148	52	undergoing	undergo	VBG
cord-290566-tmsocyfc	148	53	pilot	pilot	NN
cord-290566-tmsocyfc	148	54	studies	study	NNS
cord-290566-tmsocyfc	148	55	in	in	IN
cord-290566-tmsocyfc	148	56	MS	MS	NNP
cord-290566-tmsocyfc	148	57	.	.	.
cord-290566-tmsocyfc	149	1	Phase	phase	NN
cord-290566-tmsocyfc	149	2	II	ii	CD
cord-290566-tmsocyfc	149	3	trials	trial	NNS
cord-290566-tmsocyfc	149	4	using	use	VBG
cord-290566-tmsocyfc	149	5	antibodies	antibody	NNS
cord-290566-tmsocyfc	149	6	specifically	specifically	RB
cord-290566-tmsocyfc	149	7	targeting	target	VBG
cord-290566-tmsocyfc	149	8	the	the	DT
cord-290566-tmsocyfc	149	9	V	v	NN
cord-290566-tmsocyfc	149	10	5.2/5.3	5.2/5.3	CD
cord-290566-tmsocyfc	149	11	sequence	sequence	NN
cord-290566-tmsocyfc	149	12	of	of	IN
cord-290566-tmsocyfc	149	13	the	the	DT
cord-290566-tmsocyfc	149	14	TCR	TCR	NNP
cord-290566-tmsocyfc	149	15	have	have	VBP
cord-290566-tmsocyfc	149	16	shown	show	VBN
cord-290566-tmsocyfc	149	17	some	some	DT
cord-290566-tmsocyfc	149	18	success	success	NN
cord-290566-tmsocyfc	149	19	and	and	CC
cord-290566-tmsocyfc	149	20	no	no	DT
cord-290566-tmsocyfc	149	21	significant	significant	JJ
cord-290566-tmsocyfc	149	22	adverse	adverse	JJ
cord-290566-tmsocyfc	149	23	eVects	evect	NNS
cord-290566-tmsocyfc	149	24	Olsson	Olsson	NNP
cord-290566-tmsocyfc	149	25	et	et	NNP
cord-290566-tmsocyfc	149	26	al	al	NNP
cord-290566-tmsocyfc	149	27	.	.	NNP
cord-290566-tmsocyfc	149	28	,	,	,
cord-290566-tmsocyfc	149	29	2002	2002	CD
cord-290566-tmsocyfc	149	30	)	)	-RRB-
cord-290566-tmsocyfc	149	31	.	.	.
cord-290566-tmsocyfc	150	1	However	however	RB
cord-290566-tmsocyfc	150	2	,	,	,
cord-290566-tmsocyfc	150	3	other	other	JJ
cord-290566-tmsocyfc	150	4	groups	group	NNS
cord-290566-tmsocyfc	150	5	(	(	-LRB-
cord-290566-tmsocyfc	150	6	Gran	Gran	NNP
cord-290566-tmsocyfc	150	7	et	et	FW
cord-290566-tmsocyfc	150	8	al	al	NNP
cord-290566-tmsocyfc	150	9	.	.	.
cord-290566-tmsocyfc	151	1	,	,	,
cord-290566-tmsocyfc	151	2	1998	1998	CD
cord-290566-tmsocyfc	151	3	;	;	:
cord-290566-tmsocyfc	151	4	Lozeron	Lozeron	NNP
cord-290566-tmsocyfc	151	5	et	et	FW
cord-290566-tmsocyfc	151	6	al	al	NNP
cord-290566-tmsocyfc	151	7	.	.	NNP
cord-290566-tmsocyfc	151	8	,	,	,
cord-290566-tmsocyfc	151	9	1998	1998	CD
cord-290566-tmsocyfc	151	10	;	;	:
cord-290566-tmsocyfc	151	11	Musette	Musette	NNP
cord-290566-tmsocyfc	151	12	et	et	FW
cord-290566-tmsocyfc	151	13	al	al	NNP
cord-290566-tmsocyfc	151	14	.	.	NNP
cord-290566-tmsocyfc	151	15	,	,	,
cord-290566-tmsocyfc	151	16	1996	1996	CD
cord-290566-tmsocyfc	151	17	)	)	-RRB-
cord-290566-tmsocyfc	151	18	have	have	VBP
cord-290566-tmsocyfc	151	19	found	find	VBN
cord-290566-tmsocyfc	151	20	predominant	predominant	JJ
cord-290566-tmsocyfc	151	21	usage	usage	NN
cord-290566-tmsocyfc	151	22	of	of	IN
cord-290566-tmsocyfc	151	23	other	other	JJ
cord-290566-tmsocyfc	151	24	V	v	NN
cord-290566-tmsocyfc	151	25	chains	chain	NNS
cord-290566-tmsocyfc	151	26	,	,	,
cord-290566-tmsocyfc	151	27	indicative	indicative	JJ
cord-290566-tmsocyfc	151	28	of	of	IN
cord-290566-tmsocyfc	151	29	potential	potential	JJ
cord-290566-tmsocyfc	151	30	limitations	limitation	NNS
cord-290566-tmsocyfc	151	31	with	with	IN
cord-290566-tmsocyfc	151	32	TCR	TCR	NNP
cord-290566-tmsocyfc	151	33	V	V	NNP
cord-290566-tmsocyfc	151	34	5.2-targeted	5.2-targeted	CD
cord-290566-tmsocyfc	151	35	therapies	therapy	NNS
cord-290566-tmsocyfc	151	36	.	.	.
cord-290566-tmsocyfc	152	1	Studies	study	NNS
cord-290566-tmsocyfc	152	2	in	in	IN
cord-290566-tmsocyfc	152	3	twins	twin	NNS
cord-290566-tmsocyfc	152	4	demonstrated	demonstrate	VBD
cord-290566-tmsocyfc	152	5	similar	similar	JJ
cord-290566-tmsocyfc	152	6	selection	selection	NN
cord-290566-tmsocyfc	152	7	of	of	IN
cord-290566-tmsocyfc	152	8	TCR	TCR	NNP
cord-290566-tmsocyfc	152	9	V	V	NNP
cord-290566-tmsocyfc	152	10	chains	chain	NNS
cord-290566-tmsocyfc	152	11	in	in	IN
cord-290566-tmsocyfc	152	12	concordant	concordant	JJ
cord-290566-tmsocyfc	152	13	twins	twin	NNS
cord-290566-tmsocyfc	152	14	in	in	IN
cord-290566-tmsocyfc	152	15	response	response	NN
cord-290566-tmsocyfc	152	16	to	to	IN
cord-290566-tmsocyfc	152	17	MBP	MBP	NNP
cord-290566-tmsocyfc	152	18	,	,	,
cord-290566-tmsocyfc	152	19	when	when	WRB
cord-290566-tmsocyfc	152	20	compared	compare	VBN
cord-290566-tmsocyfc	152	21	to	to	IN
cord-290566-tmsocyfc	152	22	discordant	discordant	JJ
cord-290566-tmsocyfc	152	23	twins	twin	NNS
cord-290566-tmsocyfc	152	24	or	or	CC
cord-290566-tmsocyfc	152	25	controls	control	NNS
cord-290566-tmsocyfc	152	26	,	,	,
cord-290566-tmsocyfc	152	27	suggesting	suggest	VBG
cord-290566-tmsocyfc	152	28	a	a	DT
cord-290566-tmsocyfc	152	29	genetic	genetic	JJ
cord-290566-tmsocyfc	152	30	basis	basis	NN
cord-290566-tmsocyfc	152	31	for	for	IN
cord-290566-tmsocyfc	152	32	the	the	DT
cord-290566-tmsocyfc	152	33	evolution	evolution	NN
cord-290566-tmsocyfc	152	34	of	of	IN
cord-290566-tmsocyfc	152	35	self	self	NN
cord-290566-tmsocyfc	152	36	-	-	HYPH
cord-290566-tmsocyfc	152	37	antigen	antigen	NN
cord-290566-tmsocyfc	152	38	T	t	NN
cord-290566-tmsocyfc	152	39	-	-	HYPH
cord-290566-tmsocyfc	152	40	cell	cell	NN
cord-290566-tmsocyfc	152	41	responses	response	NNS
cord-290566-tmsocyfc	152	42	(	(	-LRB-
cord-290566-tmsocyfc	152	43	Utz	Utz	NNP
cord-290566-tmsocyfc	152	44	et	et	NNP
cord-290566-tmsocyfc	152	45	al	al	NNP
cord-290566-tmsocyfc	152	46	.	.	NNP
cord-290566-tmsocyfc	152	47	,	,	,
cord-290566-tmsocyfc	152	48	1993	1993	CD
cord-290566-tmsocyfc	152	49	)	)	-RRB-
cord-290566-tmsocyfc	152	50	.	.	.
cord-290566-tmsocyfc	153	1	MS	MS	NNP
cord-290566-tmsocyfc	153	2	patients	patient	NNS
cord-290566-tmsocyfc	153	3	treated	treat	VBN
cord-290566-tmsocyfc	153	4	with	with	IN
cord-290566-tmsocyfc	153	5	autologous	autologous	JJ
cord-290566-tmsocyfc	153	6	hematopoietic	hematopoietic	JJ
cord-290566-tmsocyfc	153	7	stem	stem	NN
cord-290566-tmsocyfc	153	8	cell	cell	NN
cord-290566-tmsocyfc	153	9	transplantation	transplantation	NN
cord-290566-tmsocyfc	153	10	demonstrated	demonstrate	VBD
cord-290566-tmsocyfc	153	11	an	an	DT
cord-290566-tmsocyfc	153	12	increase	increase	NN
cord-290566-tmsocyfc	153	13	in	in	IN
cord-290566-tmsocyfc	153	14	naive	naive	JJ
cord-290566-tmsocyfc	153	15	compared	compare	VBN
cord-290566-tmsocyfc	153	16	to	to	IN
cord-290566-tmsocyfc	153	17	memory	memory	NN
cord-290566-tmsocyfc	153	18	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	153	19	T	T	NNP
cord-290566-tmsocyfc	153	20	cells	cell	NNS
cord-290566-tmsocyfc	153	21	,	,	,
cord-290566-tmsocyfc	153	22	with	with	IN
cord-290566-tmsocyfc	153	23	increased	increase	VBN
cord-290566-tmsocyfc	153	24	TCR	TCR	NNP
cord-290566-tmsocyfc	153	25	diversity	diversity	NN
cord-290566-tmsocyfc	153	26	indicative	indicative	JJ
cord-290566-tmsocyfc	153	27	of	of	IN
cord-290566-tmsocyfc	153	28	broader	broad	JJR
cord-290566-tmsocyfc	153	29	clonal	clonal	JJ
cord-290566-tmsocyfc	153	30	phenotypes	phenotype	NNS
cord-290566-tmsocyfc	153	31	2	2	CD
cord-290566-tmsocyfc	153	32	years	year	NNS
cord-290566-tmsocyfc	153	33	following	follow	VBG
cord-290566-tmsocyfc	153	34	therapy	therapy	NN
cord-290566-tmsocyfc	153	35	(	(	-LRB-
cord-290566-tmsocyfc	153	36	Muraro	Muraro	NNP
cord-290566-tmsocyfc	153	37	et	et	NNP
cord-290566-tmsocyfc	153	38	al	al	NNP
cord-290566-tmsocyfc	153	39	.	.	NNP
cord-290566-tmsocyfc	153	40	,	,	,
cord-290566-tmsocyfc	153	41	2005	2005	CD
cord-290566-tmsocyfc	153	42	)	)	-RRB-
cord-290566-tmsocyfc	153	43	.	.	.
cord-290566-tmsocyfc	154	1	A	a	DT
cord-290566-tmsocyfc	154	2	separate	separate	JJ
cord-290566-tmsocyfc	154	3	study	study	NN
cord-290566-tmsocyfc	154	4	ascertained	ascertain	VBD
cord-290566-tmsocyfc	154	5	similar	similar	JJ
cord-290566-tmsocyfc	154	6	findings	finding	NNS
cord-290566-tmsocyfc	154	7	and	and	CC
cord-290566-tmsocyfc	154	8	found	find	VBD
cord-290566-tmsocyfc	154	9	that	that	IN
cord-290566-tmsocyfc	154	10	MBP	MBP	NNP
cord-290566-tmsocyfc	154	11	-	-	HYPH
cord-290566-tmsocyfc	154	12	reactive	reactive	JJ
cord-290566-tmsocyfc	154	13	T	T	NNP
cord-290566-tmsocyfc	154	14	cells	cell	NNS
cord-290566-tmsocyfc	154	15	demonstrated	demonstrate	VBD
cord-290566-tmsocyfc	154	16	broader	broad	JJR
cord-290566-tmsocyfc	154	17	epitope	epitope	NN
cord-290566-tmsocyfc	154	18	recognition	recognition	NN
cord-290566-tmsocyfc	154	19	following	follow	VBG
cord-290566-tmsocyfc	154	20	reconstitution	reconstitution	NN
cord-290566-tmsocyfc	154	21	(	(	-LRB-
cord-290566-tmsocyfc	154	22	Sun	Sun	NNP
cord-290566-tmsocyfc	154	23	et	et	FW
cord-290566-tmsocyfc	154	24	al	al	NNP
cord-290566-tmsocyfc	154	25	.	.	NNP
cord-290566-tmsocyfc	154	26	,	,	,
cord-290566-tmsocyfc	154	27	2004	2004	CD
cord-290566-tmsocyfc	154	28	)	)	-RRB-
cord-290566-tmsocyfc	154	29	.	.	.
cord-290566-tmsocyfc	155	1	Pathologically	pathologically	RB
cord-290566-tmsocyfc	155	2	,	,	,
cord-290566-tmsocyfc	155	3	MS	MS	NNP
cord-290566-tmsocyfc	155	4	lesions	lesion	NNS
cord-290566-tmsocyfc	155	5	are	be	VBP
cord-290566-tmsocyfc	155	6	characterized	characterize	VBN
cord-290566-tmsocyfc	155	7	by	by	IN
cord-290566-tmsocyfc	155	8	perivascular	perivascular	NNP
cord-290566-tmsocyfc	155	9	infiltrates	infiltrate	VBZ
cord-290566-tmsocyfc	155	10	of	of	IN
cord-290566-tmsocyfc	155	11	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	155	12	and	and	CC
cord-290566-tmsocyfc	155	13	CD8þ	CD8þ	NNP
cord-290566-tmsocyfc	155	14	T	T	NNP
cord-290566-tmsocyfc	155	15	cells	cell	NNS
cord-290566-tmsocyfc	155	16	and	and	CC
cord-290566-tmsocyfc	155	17	macrophages	macrophage	NNS
cord-290566-tmsocyfc	155	18	(	(	-LRB-
cord-290566-tmsocyfc	155	19	Prineas	Prineas	NNP
cord-290566-tmsocyfc	155	20	and	and	CC
cord-290566-tmsocyfc	155	21	Wright	Wright	NNP
cord-290566-tmsocyfc	155	22	,	,	,
cord-290566-tmsocyfc	155	23	1978	1978	CD
cord-290566-tmsocyfc	155	24	;	;	:
cord-290566-tmsocyfc	156	1	Traugott	Traugott	NNP
cord-290566-tmsocyfc	156	2	et	et	NNP
cord-290566-tmsocyfc	156	3	al	al	NNP
cord-290566-tmsocyfc	156	4	.	.	NNP
cord-290566-tmsocyfc	156	5	,	,	,
cord-290566-tmsocyfc	156	6	1983b	1983b	CD
cord-290566-tmsocyfc	156	7	)	)	-RRB-
cord-290566-tmsocyfc	156	8	.	.	.
cord-290566-tmsocyfc	157	1	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	157	2	and	and	CC
cord-290566-tmsocyfc	157	3	CD8þ	CD8þ	NNP
cord-290566-tmsocyfc	157	4	T	T	NNP
cord-290566-tmsocyfc	157	5	cells	cell	NNS
cord-290566-tmsocyfc	157	6	and	and	CC
cord-290566-tmsocyfc	157	7	macrophages	macrophage	NNS
cord-290566-tmsocyfc	157	8	are	be	VBP
cord-290566-tmsocyfc	157	9	also	also	RB
cord-290566-tmsocyfc	157	10	found	find	VBN
cord-290566-tmsocyfc	157	11	toward	toward	IN
cord-290566-tmsocyfc	157	12	the	the	DT
cord-290566-tmsocyfc	157	13	periphery	periphery	NN
cord-290566-tmsocyfc	157	14	of	of	IN
cord-290566-tmsocyfc	157	15	the	the	DT
cord-290566-tmsocyfc	157	16	lesion	lesion	NN
cord-290566-tmsocyfc	157	17	and	and	CC
cord-290566-tmsocyfc	157	18	in	in	IN
cord-290566-tmsocyfc	157	19	the	the	DT
cord-290566-tmsocyfc	157	20	normal	normal	JJ
cord-290566-tmsocyfc	157	21	appearing	appear	VBG
cord-290566-tmsocyfc	157	22	white	white	JJ
cord-290566-tmsocyfc	157	23	matter	matter	NN
cord-290566-tmsocyfc	158	1	(	(	-LRB-
cord-290566-tmsocyfc	158	2	Traugott	Traugott	NNP
cord-290566-tmsocyfc	158	3	et	et	FW
cord-290566-tmsocyfc	158	4	al	al	NNP
cord-290566-tmsocyfc	158	5	.	.	NNP
cord-290566-tmsocyfc	158	6	,	,	,
cord-290566-tmsocyfc	158	7	1983a	1983a	CD
cord-290566-tmsocyfc	158	8	)	)	-RRB-
cord-290566-tmsocyfc	158	9	.	.	.
cord-290566-tmsocyfc	159	1	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	159	2	T	T	NNP
cord-290566-tmsocyfc	159	3	cells	cell	NNS
cord-290566-tmsocyfc	159	4	were	be	VBD
cord-290566-tmsocyfc	159	5	shown	show	VBN
cord-290566-tmsocyfc	159	6	to	to	TO
cord-290566-tmsocyfc	159	7	predominate	predominate	VB
cord-290566-tmsocyfc	159	8	in	in	IN
cord-290566-tmsocyfc	159	9	acute	acute	JJ
cord-290566-tmsocyfc	159	10	lesions	lesion	NNS
cord-290566-tmsocyfc	159	11	,	,	,
cord-290566-tmsocyfc	159	12	while	while	IN
cord-290566-tmsocyfc	159	13	CD8þ	CD8þ	NNP
cord-290566-tmsocyfc	159	14	T	T	NNP
cord-290566-tmsocyfc	159	15	cells	cell	NNS
cord-290566-tmsocyfc	159	16	were	be	VBD
cord-290566-tmsocyfc	159	17	observed	observe	VBN
cord-290566-tmsocyfc	159	18	more	more	RBR
cord-290566-tmsocyfc	159	19	frequently	frequently	RB
cord-290566-tmsocyfc	159	20	in	in	IN
cord-290566-tmsocyfc	159	21	chronic	chronic	JJ
cord-290566-tmsocyfc	159	22	lesions	lesion	NNS
cord-290566-tmsocyfc	159	23	(	(	-LRB-
cord-290566-tmsocyfc	159	24	Raine	Raine	NNP
cord-290566-tmsocyfc	159	25	,	,	,
cord-290566-tmsocyfc	159	26	1994	1994	CD
cord-290566-tmsocyfc	159	27	)	)	-RRB-
cord-290566-tmsocyfc	159	28	.	.	.
cord-290566-tmsocyfc	160	1	Similar	similar	JJ
cord-290566-tmsocyfc	160	2	densities	density	NNS
cord-290566-tmsocyfc	160	3	of	of	IN
cord-290566-tmsocyfc	160	4	CD3þ	CD3þ	NNP
cord-290566-tmsocyfc	160	5	T	T	NNP
cord-290566-tmsocyfc	160	6	cells	cell	NNS
cord-290566-tmsocyfc	160	7	have	have	VBP
cord-290566-tmsocyfc	160	8	been	be	VBN
cord-290566-tmsocyfc	160	9	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	160	10	in	in	IN
cord-290566-tmsocyfc	160	11	all	all	DT
cord-290566-tmsocyfc	160	12	four	four	CD
cord-290566-tmsocyfc	160	13	of	of	IN
cord-290566-tmsocyfc	160	14	the	the	DT
cord-290566-tmsocyfc	160	15	histopathologic	histopathologic	JJ
cord-290566-tmsocyfc	160	16	subtypes	subtype	NNS
cord-290566-tmsocyfc	160	17	of	of	IN
cord-290566-tmsocyfc	160	18	MS	MS	NNP
cord-290566-tmsocyfc	160	19	,	,	,
cord-290566-tmsocyfc	160	20	although	although	IN
cord-290566-tmsocyfc	160	21	type	type	NN
cord-290566-tmsocyfc	160	22	III	III	NNP
cord-290566-tmsocyfc	160	23	and	and	CC
cord-290566-tmsocyfc	160	24	IV	IV	NNP
cord-290566-tmsocyfc	160	25	lesions	lesion	NNS
cord-290566-tmsocyfc	160	26	are	be	VBP
cord-290566-tmsocyfc	160	27	additionally	additionally	RB
cord-290566-tmsocyfc	160	28	characterized	characterize	VBN
cord-290566-tmsocyfc	160	29	by	by	IN
cord-290566-tmsocyfc	160	30	prominent	prominent	JJ
cord-290566-tmsocyfc	160	31	oligodendrocyte	oligodendrocyte	NNP
cord-290566-tmsocyfc	160	32	degeneration	degeneration	NN
cord-290566-tmsocyfc	160	33	(	(	-LRB-
cord-290566-tmsocyfc	160	34	Lucchinetti	Lucchinetti	NNP
cord-290566-tmsocyfc	160	35	et	et	NNP
cord-290566-tmsocyfc	160	36	al	al	NNP
cord-290566-tmsocyfc	160	37	.	.	NNP
cord-290566-tmsocyfc	160	38	,	,	,
cord-290566-tmsocyfc	160	39	1996	1996	CD
cord-290566-tmsocyfc	160	40	)	)	-RRB-
cord-290566-tmsocyfc	160	41	.	.	.
cord-290566-tmsocyfc	161	1	Attempts	attempt	NNS
cord-290566-tmsocyfc	161	2	to	to	TO
cord-290566-tmsocyfc	161	3	isolate	isolate	VB
cord-290566-tmsocyfc	161	4	T	t	NN
cord-290566-tmsocyfc	161	5	-	-	HYPH
cord-290566-tmsocyfc	161	6	cell	cell	NN
cord-290566-tmsocyfc	161	7	clones	clone	NNS
cord-290566-tmsocyfc	161	8	from	from	IN
cord-290566-tmsocyfc	161	9	the	the	DT
cord-290566-tmsocyfc	161	10	brains	brain	NNS
cord-290566-tmsocyfc	161	11	of	of	IN
cord-290566-tmsocyfc	161	12	MS	MS	NNP
cord-290566-tmsocyfc	161	13	patients	patient	NNS
cord-290566-tmsocyfc	161	14	failed	fail	VBD
cord-290566-tmsocyfc	161	15	to	to	TO
cord-290566-tmsocyfc	161	16	show	show	VB
cord-290566-tmsocyfc	161	17	either	either	CC
cord-290566-tmsocyfc	161	18	MBP	MBP	NNP
cord-290566-tmsocyfc	161	19	or	or	CC
cord-290566-tmsocyfc	161	20	PLP	PLP	NNP
cord-290566-tmsocyfc	161	21	reactivity	reactivity	NN
cord-290566-tmsocyfc	161	22	(	(	-LRB-
cord-290566-tmsocyfc	161	23	Hafler	Hafler	NNP
cord-290566-tmsocyfc	161	24	et	et	NNP
cord-290566-tmsocyfc	161	25	al	al	NNP
cord-290566-tmsocyfc	161	26	.	.	NNP
cord-290566-tmsocyfc	161	27	,	,	,
cord-290566-tmsocyfc	161	28	1987	1987	CD
cord-290566-tmsocyfc	161	29	)	)	-RRB-
cord-290566-tmsocyfc	161	30	.	.	.
cord-290566-tmsocyfc	162	1	TCR	TCR	NNP
cord-290566-tmsocyfc	162	2	analysis	analysis	NN
cord-290566-tmsocyfc	162	3	from	from	IN
cord-290566-tmsocyfc	162	4	MS	MS	NNP
cord-290566-tmsocyfc	162	5	lesions	lesion	NNS
cord-290566-tmsocyfc	162	6	demonstrated	demonstrate	VBD
cord-290566-tmsocyfc	162	7	a	a	DT
cord-290566-tmsocyfc	162	8	broad	broad	JJ
cord-290566-tmsocyfc	162	9	TCR	TCR	NNP
cord-290566-tmsocyfc	162	10	V	v	NN
cord-290566-tmsocyfc	162	11	and	and	CC
cord-290566-tmsocyfc	162	12	V	v	NN
cord-290566-tmsocyfc	162	13	repertoires	repertoire	NNS
cord-290566-tmsocyfc	162	14	in	in	IN
cord-290566-tmsocyfc	162	15	active	active	JJ
cord-290566-tmsocyfc	162	16	lesions	lesion	NNS
cord-290566-tmsocyfc	162	17	,	,	,
cord-290566-tmsocyfc	162	18	while	while	IN
cord-290566-tmsocyfc	162	19	fewer	few	JJR
cord-290566-tmsocyfc	162	20	TCR	TCR	NNP
cord-290566-tmsocyfc	162	21	V	V	NNP
cord-290566-tmsocyfc	162	22	genes	gene	NNS
cord-290566-tmsocyfc	162	23	were	be	VBD
cord-290566-tmsocyfc	162	24	detected	detect	VBN
cord-290566-tmsocyfc	162	25	in	in	IN
cord-290566-tmsocyfc	162	26	chronic	chronic	JJ
cord-290566-tmsocyfc	162	27	plaques	plaque	NNS
cord-290566-tmsocyfc	162	28	and	and	CC
cord-290566-tmsocyfc	162	29	control	control	NN
cord-290566-tmsocyfc	162	30	samples	sample	NNS
cord-290566-tmsocyfc	163	1	(	(	-LRB-
cord-290566-tmsocyfc	163	2	Wucherpfennig	Wucherpfennig	NNP
cord-290566-tmsocyfc	163	3	et	et	NNP
cord-290566-tmsocyfc	163	4	al	al	NNP
cord-290566-tmsocyfc	163	5	.	.	NNP
cord-290566-tmsocyfc	163	6	,	,	,
cord-290566-tmsocyfc	163	7	1992	1992	CD
cord-290566-tmsocyfc	163	8	)	)	-RRB-
cord-290566-tmsocyfc	163	9	.	.	.
cord-290566-tmsocyfc	164	1	Other	other	JJ
cord-290566-tmsocyfc	164	2	studies	study	NNS
cord-290566-tmsocyfc	164	3	demonstrated	demonstrate	VBD
cord-290566-tmsocyfc	164	4	restricted	restrict	VBN
cord-290566-tmsocyfc	164	5	TCR	TCR	NNP
cord-290566-tmsocyfc	164	6	specificities	specificity	NNS
cord-290566-tmsocyfc	164	7	,	,	,
cord-290566-tmsocyfc	164	8	with	with	IN
cord-290566-tmsocyfc	164	9	rearranged	rearrange	VBN
cord-290566-tmsocyfc	164	10	V	v	NN
cord-290566-tmsocyfc	164	11	5.2	5.2	CD
cord-290566-tmsocyfc	164	12	genes	gene	NNS
cord-290566-tmsocyfc	164	13	found	find	VBN
cord-290566-tmsocyfc	164	14	in	in	IN
cord-290566-tmsocyfc	164	15	the	the	DT
cord-290566-tmsocyfc	164	16	brains	brain	NNS
cord-290566-tmsocyfc	164	17	of	of	IN
cord-290566-tmsocyfc	164	18	all	all	DT
cord-290566-tmsocyfc	164	19	patients	patient	NNS
cord-290566-tmsocyfc	164	20	who	who	WP
cord-290566-tmsocyfc	164	21	were	be	VBD
cord-290566-tmsocyfc	164	22	HLA	HLA	NNP
cord-290566-tmsocyfc	164	23	DRB1	DRB1	NNP
cord-290566-tmsocyfc	164	24	*	*	NFP
cord-290566-tmsocyfc	164	25	1501	1501	CD
cord-290566-tmsocyfc	164	26	,	,	,
cord-290566-tmsocyfc	164	27	DQA1	DQA1	NNPS
cord-290566-tmsocyfc	164	28	*	*	NFP
cord-290566-tmsocyfc	164	29	0102	0102	CD
cord-290566-tmsocyfc	164	30	,	,	,
cord-290566-tmsocyfc	164	31	DQB1	DQB1	NNP
cord-290566-tmsocyfc	164	32	*	*	NFP
cord-290566-tmsocyfc	164	33	0602	0602	CD
cord-290566-tmsocyfc	164	34	,	,	,
cord-290566-tmsocyfc	164	35	and	and	CC
cord-290566-tmsocyfc	164	36	DPB1	DPB1	NNP
cord-290566-tmsocyfc	164	37	*	*	NFP
cord-290566-tmsocyfc	164	38	0401	0401	CD
cord-290566-tmsocyfc	164	39	positive	positive	JJ
cord-290566-tmsocyfc	164	40	,	,	,
cord-290566-tmsocyfc	164	41	suggesting	suggest	VBG
cord-290566-tmsocyfc	164	42	that	that	IN
cord-290566-tmsocyfc	164	43	MHC	MHC	NNP
cord-290566-tmsocyfc	164	44	class	class	NN
cord-290566-tmsocyfc	164	45	II	II	NNP
cord-290566-tmsocyfc	164	46	genotype	genotype	NN
cord-290566-tmsocyfc	164	47	may	may	MD
cord-290566-tmsocyfc	164	48	play	play	VB
cord-290566-tmsocyfc	164	49	a	a	DT
cord-290566-tmsocyfc	164	50	role	role	NN
cord-290566-tmsocyfc	164	51	in	in	IN
cord-290566-tmsocyfc	164	52	VDJ	VDJ	NNP
cord-290566-tmsocyfc	164	53	rearrangements	rearrangement	NNS
cord-290566-tmsocyfc	164	54	in	in	IN
cord-290566-tmsocyfc	164	55	MS	MS	NNP
cord-290566-tmsocyfc	164	56	lesions	lesion	NNS
cord-290566-tmsocyfc	164	57	(	(	-LRB-
cord-290566-tmsocyfc	164	58	Oksenberg	Oksenberg	NNP
cord-290566-tmsocyfc	164	59	et	et	NNP
cord-290566-tmsocyfc	164	60	al	al	NNP
cord-290566-tmsocyfc	164	61	.	.	NNP
cord-290566-tmsocyfc	164	62	,	,	,
cord-290566-tmsocyfc	164	63	1993	1993	CD
cord-290566-tmsocyfc	164	64	)	)	-RRB-
cord-290566-tmsocyfc	164	65	.	.	.
cord-290566-tmsocyfc	165	1	T	T	NNP
cord-290566-tmsocyfc	165	2	cells	cell	NNS
cord-290566-tmsocyfc	165	3	in	in	IN
cord-290566-tmsocyfc	165	4	parenchymal	parenchymal	NN
cord-290566-tmsocyfc	165	5	MS	MS	NNP
cord-290566-tmsocyfc	165	6	lesions	lesion	NNS
cord-290566-tmsocyfc	165	7	lacked	lack	VBD
cord-290566-tmsocyfc	165	8	CCR7	CCR7	NNP
cord-290566-tmsocyfc	165	9	,	,	,
cord-290566-tmsocyfc	165	10	indicating	indicate	VBG
cord-290566-tmsocyfc	165	11	a	a	DT
cord-290566-tmsocyfc	165	12	diVerentiation	diverentiation	NN
cord-290566-tmsocyfc	165	13	of	of	IN
cord-290566-tmsocyfc	165	14	central	central	JJ
cord-290566-tmsocyfc	165	15	-	-	HYPH
cord-290566-tmsocyfc	165	16	memory	memory	NN
cord-290566-tmsocyfc	165	17	T	t	NN
cord-290566-tmsocyfc	165	18	cells	cell	NNS
cord-290566-tmsocyfc	165	19	into	into	IN
cord-290566-tmsocyfc	165	20	eVector	eVector	NNP
cord-290566-tmsocyfc	165	21	memory	memory	NN
cord-290566-tmsocyfc	165	22	cells	cell	NNS
cord-290566-tmsocyfc	165	23	presumably	presumably	RB
cord-290566-tmsocyfc	165	24	on	on	IN
cord-290566-tmsocyfc	165	25	restimulation	restimulation	NN
cord-290566-tmsocyfc	165	26	by	by	IN
cord-290566-tmsocyfc	165	27	antigen	antigen	NN
cord-290566-tmsocyfc	165	28	within	within	IN
cord-290566-tmsocyfc	165	29	the	the	DT
cord-290566-tmsocyfc	165	30	CNS	CNS	NNP
cord-290566-tmsocyfc	166	1	(	(	-LRB-
cord-290566-tmsocyfc	166	2	Kivisakk	Kivisakk	NNP
cord-290566-tmsocyfc	166	3	et	et	NNP
cord-290566-tmsocyfc	166	4	al	al	NNP
cord-290566-tmsocyfc	166	5	.	.	NNP
cord-290566-tmsocyfc	166	6	,	,	,
cord-290566-tmsocyfc	166	7	2004	2004	CD
cord-290566-tmsocyfc	166	8	)	)	-RRB-
cord-290566-tmsocyfc	166	9	.	.	.
cord-290566-tmsocyfc	167	1	In	in	IN
cord-290566-tmsocyfc	167	2	summary	summary	NN
cord-290566-tmsocyfc	167	3	,	,	,
cord-290566-tmsocyfc	167	4	multiple	multiple	JJ
cord-290566-tmsocyfc	167	5	studies	study	NNS
cord-290566-tmsocyfc	167	6	have	have	VBP
cord-290566-tmsocyfc	167	7	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	167	8	the	the	DT
cord-290566-tmsocyfc	167	9	presence	presence	NN
cord-290566-tmsocyfc	167	10	of	of	IN
cord-290566-tmsocyfc	167	11	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	167	12	T	T	NNP
cord-290566-tmsocyfc	167	13	cells	cell	NNS
cord-290566-tmsocyfc	167	14	in	in	IN
cord-290566-tmsocyfc	167	15	MS	MS	NNP
cord-290566-tmsocyfc	167	16	lesions	lesion	NNS
cord-290566-tmsocyfc	167	17	,	,	,
cord-290566-tmsocyfc	167	18	arguing	argue	VBG
cord-290566-tmsocyfc	167	19	for	for	IN
cord-290566-tmsocyfc	167	20	a	a	DT
cord-290566-tmsocyfc	167	21	central	central	JJ
cord-290566-tmsocyfc	167	22	role	role	NN
cord-290566-tmsocyfc	167	23	in	in	IN
cord-290566-tmsocyfc	167	24	MS	MS	NNP
cord-290566-tmsocyfc	167	25	pathogenesis	pathogenesis	NN
cord-290566-tmsocyfc	167	26	.	.	.
cord-290566-tmsocyfc	168	1	The	the	DT
cord-290566-tmsocyfc	168	2	lack	lack	NN
cord-290566-tmsocyfc	168	3	of	of	IN
cord-290566-tmsocyfc	168	4	52	52	CD
cord-290566-tmsocyfc	168	5	TANUJA	TANUJA	NNP
cord-290566-tmsocyfc	168	6	CHITNIS	CHITNIS	NNP
cord-290566-tmsocyfc	168	7	consensus	consensus	NN
cord-290566-tmsocyfc	168	8	regarding	regard	VBG
cord-290566-tmsocyfc	168	9	T	t	NN
cord-290566-tmsocyfc	168	10	-	-	HYPH
cord-290566-tmsocyfc	168	11	cell	cell	NN
cord-290566-tmsocyfc	168	12	specificities	specificity	NNS
cord-290566-tmsocyfc	168	13	suggest	suggest	VBP
cord-290566-tmsocyfc	168	14	a	a	DT
cord-290566-tmsocyfc	168	15	heterogeneity	heterogeneity	NN
cord-290566-tmsocyfc	168	16	in	in	IN
cord-290566-tmsocyfc	168	17	T	t	NN
cord-290566-tmsocyfc	168	18	-	-	HYPH
cord-290566-tmsocyfc	168	19	cell	cell	NN
cord-290566-tmsocyfc	168	20	responses	response	NNS
cord-290566-tmsocyfc	168	21	at	at	IN
cord-290566-tmsocyfc	168	22	the	the	DT
cord-290566-tmsocyfc	168	23	time	time	NN
cord-290566-tmsocyfc	168	24	of	of	IN
cord-290566-tmsocyfc	168	25	analysis	analysis	NN
cord-290566-tmsocyfc	168	26	,	,	,
cord-290566-tmsocyfc	168	27	which	which	WDT
cord-290566-tmsocyfc	168	28	may	may	MD
cord-290566-tmsocyfc	168	29	be	be	VB
cord-290566-tmsocyfc	168	30	a	a	DT
cord-290566-tmsocyfc	168	31	result	result	NN
cord-290566-tmsocyfc	168	32	of	of	IN
cord-290566-tmsocyfc	168	33	epitope	epitope	NN
cord-290566-tmsocyfc	168	34	spreading	spread	VBG
cord-290566-tmsocyfc	168	35	in	in	IN
cord-290566-tmsocyfc	168	36	chronic	chronic	JJ
cord-290566-tmsocyfc	168	37	disease	disease	NN
cord-290566-tmsocyfc	168	38	.	.	.
cord-290566-tmsocyfc	169	1	Costimulatory	Costimulatory	NNP
cord-290566-tmsocyfc	169	2	pathways	pathway	NNS
cord-290566-tmsocyfc	169	3	deliver	deliver	VBP
cord-290566-tmsocyfc	169	4	a	a	DT
cord-290566-tmsocyfc	169	5	positive	positive	JJ
cord-290566-tmsocyfc	169	6	or	or	CC
cord-290566-tmsocyfc	169	7	negative	negative	JJ
cord-290566-tmsocyfc	169	8	signal	signal	NN
cord-290566-tmsocyfc	169	9	for	for	IN
cord-290566-tmsocyfc	169	10	T	t	NN
cord-290566-tmsocyfc	169	11	-	-	HYPH
cord-290566-tmsocyfc	169	12	cell	cell	NN
cord-290566-tmsocyfc	169	13	activation	activation	NN
cord-290566-tmsocyfc	169	14	,	,	,
cord-290566-tmsocyfc	169	15	and	and	CC
cord-290566-tmsocyfc	169	16	thus	thus	RB
cord-290566-tmsocyfc	169	17	represent	represent	VB
cord-290566-tmsocyfc	169	18	an	an	DT
cord-290566-tmsocyfc	169	19	important	important	JJ
cord-290566-tmsocyfc	169	20	control	control	NN
cord-290566-tmsocyfc	169	21	step	step	NN
cord-290566-tmsocyfc	169	22	in	in	IN
cord-290566-tmsocyfc	169	23	the	the	DT
cord-290566-tmsocyfc	169	24	immune	immune	JJ
cord-290566-tmsocyfc	169	25	response	response	NN
cord-290566-tmsocyfc	169	26	.	.	.
cord-290566-tmsocyfc	170	1	The	the	DT
cord-290566-tmsocyfc	170	2	CD28	CD28	NNP
cord-290566-tmsocyfc	170	3	/	/	SYM
cord-290566-tmsocyfc	170	4	CTLA-4-B7	CTLA-4-B7	NNP
cord-290566-tmsocyfc	170	5	-	-	HYPH
cord-290566-tmsocyfc	170	6	1/2	1/2	CD
cord-290566-tmsocyfc	170	7	family	family	NN
cord-290566-tmsocyfc	170	8	of	of	IN
cord-290566-tmsocyfc	170	9	costimulatory	costimulatory	NNP
cord-290566-tmsocyfc	170	10	molecules	molecule	NNS
cord-290566-tmsocyfc	170	11	represents	represent	VBZ
cord-290566-tmsocyfc	170	12	an	an	DT
cord-290566-tmsocyfc	170	13	important	important	JJ
cord-290566-tmsocyfc	170	14	step	step	NN
cord-290566-tmsocyfc	170	15	in	in	IN
cord-290566-tmsocyfc	170	16	the	the	DT
cord-290566-tmsocyfc	170	17	activation	activation	NN
cord-290566-tmsocyfc	170	18	of	of	IN
cord-290566-tmsocyfc	170	19	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	170	20	T	T	NNP
cord-290566-tmsocyfc	170	21	cells	cell	NNS
cord-290566-tmsocyfc	170	22	.	.	.
cord-290566-tmsocyfc	171	1	Lesions	lesion	NNS
cord-290566-tmsocyfc	171	2	in	in	IN
cord-290566-tmsocyfc	171	3	the	the	DT
cord-290566-tmsocyfc	171	4	CNS	CNS	NNP
cord-290566-tmsocyfc	171	5	of	of	IN
cord-290566-tmsocyfc	171	6	patients	patient	NNS
cord-290566-tmsocyfc	171	7	with	with	IN
cord-290566-tmsocyfc	171	8	MS	MS	NNP
cord-290566-tmsocyfc	171	9	were	be	VBD
cord-290566-tmsocyfc	171	10	found	find	VBN
cord-290566-tmsocyfc	171	11	to	to	TO
cord-290566-tmsocyfc	171	12	be	be	VB
cord-290566-tmsocyfc	171	13	exclusively	exclusively	RB
cord-290566-tmsocyfc	171	14	associated	associate	VBN
cord-290566-tmsocyfc	171	15	with	with	IN
cord-290566-tmsocyfc	171	16	the	the	DT
cord-290566-tmsocyfc	171	17	expression	expression	NN
cord-290566-tmsocyfc	171	18	of	of	IN
cord-290566-tmsocyfc	171	19	B7	B7	NNP
cord-290566-tmsocyfc	171	20	-	-	HYPH
cord-290566-tmsocyfc	171	21	1	1	CD
cord-290566-tmsocyfc	171	22	in	in	IN
cord-290566-tmsocyfc	171	23	perivenular	perivenular	NNP
cord-290566-tmsocyfc	171	24	lymphocytes	lymphocyte	NNS
cord-290566-tmsocyfc	171	25	,	,	,
cord-290566-tmsocyfc	171	26	while	while	IN
cord-290566-tmsocyfc	171	27	B7	B7	NNP
cord-290566-tmsocyfc	171	28	-	-	HYPH
cord-290566-tmsocyfc	171	29	2	2	NNP
cord-290566-tmsocyfc	171	30	was	be	VBD
cord-290566-tmsocyfc	171	31	expressed	express	VBN
cord-290566-tmsocyfc	171	32	on	on	IN
cord-290566-tmsocyfc	171	33	macrophages	macrophage	NNS
cord-290566-tmsocyfc	171	34	in	in	IN
cord-290566-tmsocyfc	171	35	both	both	DT
cord-290566-tmsocyfc	171	36	MS	MS	NNP
cord-290566-tmsocyfc	171	37	and	and	CC
cord-290566-tmsocyfc	171	38	in	in	IN
cord-290566-tmsocyfc	171	39	other	other	JJ
cord-290566-tmsocyfc	171	40	neurological	neurological	JJ
cord-290566-tmsocyfc	171	41	diseases	disease	NNS
cord-290566-tmsocyfc	171	42	(	(	-LRB-
cord-290566-tmsocyfc	171	43	Windhagen	Windhagen	NNP
cord-290566-tmsocyfc	171	44	et	et	NNP
cord-290566-tmsocyfc	171	45	al	al	NNP
cord-290566-tmsocyfc	171	46	.	.	NNP
cord-290566-tmsocyfc	171	47	,	,	,
cord-290566-tmsocyfc	171	48	1995	1995	CD
cord-290566-tmsocyfc	171	49	)	)	-RRB-
cord-290566-tmsocyfc	171	50	.	.	.
cord-290566-tmsocyfc	172	1	Peripheral	peripheral	JJ
cord-290566-tmsocyfc	172	2	blood	blood	NN
cord-290566-tmsocyfc	172	3	mononuclear	mononuclear	NN
cord-290566-tmsocyfc	172	4	cells	cell	NNS
cord-290566-tmsocyfc	172	5	(	(	-LRB-
cord-290566-tmsocyfc	172	6	PBMCs	pbmc	NNS
cord-290566-tmsocyfc	172	7	)	)	-RRB-
cord-290566-tmsocyfc	172	8	,	,	,
cord-290566-tmsocyfc	172	9	isolated	isolate	VBN
cord-290566-tmsocyfc	172	10	from	from	IN
cord-290566-tmsocyfc	172	11	MS	MS	NNP
cord-290566-tmsocyfc	172	12	patients	patient	NNS
cord-290566-tmsocyfc	172	13	,	,	,
cord-290566-tmsocyfc	172	14	showed	show	VBD
cord-290566-tmsocyfc	172	15	increased	increased	JJ
cord-290566-tmsocyfc	172	16	expression	expression	NN
cord-290566-tmsocyfc	172	17	of	of	IN
cord-290566-tmsocyfc	172	18	B7	b7	NN
cord-290566-tmsocyfc	172	19	-	-	HYPH
cord-290566-tmsocyfc	172	20	1	1	CD
cord-290566-tmsocyfc	172	21	on	on	IN
cord-290566-tmsocyfc	172	22	both	both	CC
cord-290566-tmsocyfc	172	23	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	172	24	and	and	CC
cord-290566-tmsocyfc	172	25	CD8þ	CD8þ	NNP
cord-290566-tmsocyfc	172	26	cell	cell	NN
cord-290566-tmsocyfc	172	27	patients	patient	NNS
cord-290566-tmsocyfc	172	28	with	with	IN
cord-290566-tmsocyfc	172	29	rapidly	rapidly	RB
cord-290566-tmsocyfc	172	30	progressive	progressive	JJ
cord-290566-tmsocyfc	172	31	disease	disease	NN
cord-290566-tmsocyfc	172	32	,	,	,
cord-290566-tmsocyfc	172	33	compared	compare	VBN
cord-290566-tmsocyfc	172	34	to	to	IN
cord-290566-tmsocyfc	172	35	those	those	DT
cord-290566-tmsocyfc	172	36	with	with	IN
cord-290566-tmsocyfc	172	37	stable	stable	JJ
cord-290566-tmsocyfc	172	38	disease	disease	NN
cord-290566-tmsocyfc	172	39	,	,	,
cord-290566-tmsocyfc	172	40	or	or	CC
cord-290566-tmsocyfc	172	41	normal	normal	JJ
cord-290566-tmsocyfc	172	42	controls	control	NNS
cord-290566-tmsocyfc	172	43	(	(	-LRB-
cord-290566-tmsocyfc	172	44	Mena	Mena	NNP
cord-290566-tmsocyfc	172	45	and	and	CC
cord-290566-tmsocyfc	172	46	Rohowsky	Rohowsky	NNP
cord-290566-tmsocyfc	172	47	-	-	HYPH
cord-290566-tmsocyfc	172	48	Kochan	Kochan	NNP
cord-290566-tmsocyfc	172	49	,	,	,
cord-290566-tmsocyfc	172	50	1999	1999	CD
cord-290566-tmsocyfc	172	51	)	)	-RRB-
cord-290566-tmsocyfc	172	52	.	.	.
cord-290566-tmsocyfc	173	1	In	in	IN
cord-290566-tmsocyfc	173	2	a	a	DT
cord-290566-tmsocyfc	173	3	separate	separate	JJ
cord-290566-tmsocyfc	173	4	study	study	NN
cord-290566-tmsocyfc	173	5	,	,	,
cord-290566-tmsocyfc	173	6	B7	b7	NN
cord-290566-tmsocyfc	173	7	-	-	HYPH
cord-290566-tmsocyfc	173	8	1	1	CD
cord-290566-tmsocyfc	173	9	expression	expression	NN
cord-290566-tmsocyfc	173	10	localized	localize	VBN
cord-290566-tmsocyfc	173	11	to	to	IN
cord-290566-tmsocyfc	173	12	B	b	NN
cord-290566-tmsocyfc	173	13	cells	cell	NNS
cord-290566-tmsocyfc	173	14	was	be	VBD
cord-290566-tmsocyfc	173	15	found	find	VBN
cord-290566-tmsocyfc	173	16	to	to	TO
cord-290566-tmsocyfc	173	17	be	be	VB
cord-290566-tmsocyfc	173	18	increased	increase	VBN
cord-290566-tmsocyfc	173	19	during	during	IN
cord-290566-tmsocyfc	173	20	MS	MS	NNP
cord-290566-tmsocyfc	173	21	relapses	relapse	NNS
cord-290566-tmsocyfc	173	22	,	,	,
cord-290566-tmsocyfc	173	23	and	and	CC
cord-290566-tmsocyfc	173	24	treatment	treatment	NN
cord-290566-tmsocyfc	173	25	with	with	IN
cord-290566-tmsocyfc	173	26	IFN-1b	IFN-1b	NNP
cord-290566-tmsocyfc	173	27	reduced	reduce	VBD
cord-290566-tmsocyfc	173	28	the	the	DT
cord-290566-tmsocyfc	173	29	number	number	NN
cord-290566-tmsocyfc	173	30	of	of	IN
cord-290566-tmsocyfc	173	31	B7	b7	NN
cord-290566-tmsocyfc	173	32	-	-	HYPH
cord-290566-tmsocyfc	173	33	1-expressing	1-expressing	CD
cord-290566-tmsocyfc	173	34	B	b	NN
cord-290566-tmsocyfc	173	35	cells	cell	NNS
cord-290566-tmsocyfc	173	36	but	but	CC
cord-290566-tmsocyfc	173	37	increased	increase	VBD
cord-290566-tmsocyfc	173	38	the	the	DT
cord-290566-tmsocyfc	173	39	number	number	NN
cord-290566-tmsocyfc	173	40	of	of	IN
cord-290566-tmsocyfc	173	41	B7	b7	NN
cord-290566-tmsocyfc	173	42	-	-	HYPH
cord-290566-tmsocyfc	173	43	2	2	CD
cord-290566-tmsocyfc	173	44	monocytes	monocyte	NNS
cord-290566-tmsocyfc	173	45	(	(	-LRB-
cord-290566-tmsocyfc	173	46	Genc	Genc	NNP
cord-290566-tmsocyfc	173	47	et	et	FW
cord-290566-tmsocyfc	173	48	al	al	NNP
cord-290566-tmsocyfc	173	49	.	.	NNP
cord-290566-tmsocyfc	173	50	,	,	,
cord-290566-tmsocyfc	173	51	1997	1997	CD
cord-290566-tmsocyfc	173	52	)	)	-RRB-
cord-290566-tmsocyfc	173	53	.	.	.
cord-290566-tmsocyfc	174	1	In	in	IN
cord-290566-tmsocyfc	174	2	total	total	NN
cord-290566-tmsocyfc	174	3	,	,	,
cord-290566-tmsocyfc	174	4	these	these	DT
cord-290566-tmsocyfc	174	5	observations	observation	NNS
cord-290566-tmsocyfc	174	6	suggest	suggest	VBP
cord-290566-tmsocyfc	174	7	that	that	IN
cord-290566-tmsocyfc	174	8	the	the	DT
cord-290566-tmsocyfc	174	9	B7-CD28-CTLA4	B7-CD28-CTLA4	NNP
cord-290566-tmsocyfc	174	10	pathway	pathway	NN
cord-290566-tmsocyfc	174	11	is	be	VBZ
cord-290566-tmsocyfc	174	12	activated	activate	VBN
cord-290566-tmsocyfc	174	13	in	in	IN
cord-290566-tmsocyfc	174	14	MS	MS	NNP
cord-290566-tmsocyfc	174	15	,	,	,
cord-290566-tmsocyfc	174	16	and	and	CC
cord-290566-tmsocyfc	174	17	that	that	DT
cord-290566-tmsocyfc	174	18	B7	b7	NN
cord-290566-tmsocyfc	174	19	-	-	HYPH
cord-290566-tmsocyfc	174	20	1	1	CD
cord-290566-tmsocyfc	174	21	,	,	,
cord-290566-tmsocyfc	174	22	in	in	IN
cord-290566-tmsocyfc	174	23	particular	particular	JJ
cord-290566-tmsocyfc	174	24	,	,	,
cord-290566-tmsocyfc	174	25	may	may	MD
cord-290566-tmsocyfc	174	26	play	play	VB
cord-290566-tmsocyfc	174	27	an	an	DT
cord-290566-tmsocyfc	174	28	important	important	JJ
cord-290566-tmsocyfc	174	29	role	role	NN
cord-290566-tmsocyfc	174	30	in	in	IN
cord-290566-tmsocyfc	174	31	regulating	regulate	VBG
cord-290566-tmsocyfc	174	32	disease	disease	NN
cord-290566-tmsocyfc	174	33	activity	activity	NN
cord-290566-tmsocyfc	174	34	.	.	.
cord-290566-tmsocyfc	175	1	Genetic	genetic	JJ
cord-290566-tmsocyfc	175	2	polymorphisms	polymorphism	NNS
cord-290566-tmsocyfc	175	3	of	of	IN
cord-290566-tmsocyfc	175	4	costimulatory	costimulatory	NN
cord-290566-tmsocyfc	175	5	molecules	molecule	NNS
cord-290566-tmsocyfc	175	6	may	may	MD
cord-290566-tmsocyfc	175	7	contribute	contribute	VB
cord-290566-tmsocyfc	175	8	to	to	IN
cord-290566-tmsocyfc	175	9	disease	disease	NN
cord-290566-tmsocyfc	175	10	susceptibility	susceptibility	NN
cord-290566-tmsocyfc	175	11	.	.	.
cord-290566-tmsocyfc	176	1	Three	three	CD
cord-290566-tmsocyfc	176	2	CTLA-4	CTLA-4	NNS
cord-290566-tmsocyfc	176	3	gene	gene	NN
cord-290566-tmsocyfc	176	4	polymorphisms	polymorphism	NNS
cord-290566-tmsocyfc	176	5	were	be	VBD
cord-290566-tmsocyfc	176	6	found	find	VBN
cord-290566-tmsocyfc	176	7	in	in	IN
cord-290566-tmsocyfc	176	8	MS	MS	NNP
cord-290566-tmsocyfc	176	9	patients	patient	NNS
cord-290566-tmsocyfc	176	10	,	,	,
cord-290566-tmsocyfc	176	11	but	but	CC
cord-290566-tmsocyfc	176	12	not	not	RB
cord-290566-tmsocyfc	176	13	in	in	IN
cord-290566-tmsocyfc	176	14	healthy	healthy	JJ
cord-290566-tmsocyfc	176	15	controls	control	NNS
cord-290566-tmsocyfc	176	16	(	(	-LRB-
cord-290566-tmsocyfc	176	17	Ligers	Ligers	NNPS
cord-290566-tmsocyfc	176	18	et	et	FW
cord-290566-tmsocyfc	176	19	al	al	NNP
cord-290566-tmsocyfc	176	20	.	.	NNP
cord-290566-tmsocyfc	176	21	,	,	,
cord-290566-tmsocyfc	176	22	1999	1999	CD
cord-290566-tmsocyfc	176	23	)	)	-RRB-
cord-290566-tmsocyfc	176	24	,	,	,
cord-290566-tmsocyfc	176	25	however	however	RB
cord-290566-tmsocyfc	176	26	no	no	DT
cord-290566-tmsocyfc	176	27	association	association	NN
cord-290566-tmsocyfc	176	28	was	be	VBD
cord-290566-tmsocyfc	176	29	found	find	VBN
cord-290566-tmsocyfc	176	30	with	with	IN
cord-290566-tmsocyfc	176	31	disease	disease	NN
cord-290566-tmsocyfc	176	32	course	course	NN
cord-290566-tmsocyfc	176	33	or	or	CC
cord-290566-tmsocyfc	176	34	severity	severity	NN
cord-290566-tmsocyfc	176	35	(	(	-LRB-
cord-290566-tmsocyfc	177	1	Masterman	Masterman	NNP
cord-290566-tmsocyfc	177	2	et	et	NNP
cord-290566-tmsocyfc	177	3	al	al	NNP
cord-290566-tmsocyfc	177	4	.	.	NNP
cord-290566-tmsocyfc	177	5	,	,	,
cord-290566-tmsocyfc	177	6	2002	2002	CD
cord-290566-tmsocyfc	177	7	)	)	-RRB-
cord-290566-tmsocyfc	177	8	.	.	.
cord-290566-tmsocyfc	178	1	In	in	IN
cord-290566-tmsocyfc	178	2	an	an	DT
cord-290566-tmsocyfc	178	3	Olmstead	Olmstead	NNP
cord-290566-tmsocyfc	178	4	County	County	NNP
cord-290566-tmsocyfc	178	5	study	study	NN
cord-290566-tmsocyfc	178	6	,	,	,
cord-290566-tmsocyfc	178	7	two	two	CD
cord-290566-tmsocyfc	178	8	polymorphisms	polymorphism	NNS
cord-290566-tmsocyfc	178	9	were	be	VBD
cord-290566-tmsocyfc	178	10	associated	associate	VBN
cord-290566-tmsocyfc	178	11	with	with	IN
cord-290566-tmsocyfc	178	12	the	the	DT
cord-290566-tmsocyfc	178	13	presence	presence	NN
cord-290566-tmsocyfc	178	14	of	of	IN
cord-290566-tmsocyfc	178	15	MS	MS	NNP
cord-290566-tmsocyfc	178	16	(	(	-LRB-
cord-290566-tmsocyfc	178	17	Kantarci	Kantarci	NNP
cord-290566-tmsocyfc	178	18	et	et	NNP
cord-290566-tmsocyfc	178	19	al	al	NNP
cord-290566-tmsocyfc	178	20	.	.	NNP
cord-290566-tmsocyfc	178	21	,	,	,
cord-290566-tmsocyfc	178	22	2003	2003	CD
cord-290566-tmsocyfc	178	23	)	)	-RRB-
cord-290566-tmsocyfc	178	24	.	.	.
cord-290566-tmsocyfc	179	1	The	the	DT
cord-290566-tmsocyfc	179	2	Canadian	Canadian	NNP
cord-290566-tmsocyfc	179	3	Collaborative	Collaborative	NNP
cord-290566-tmsocyfc	179	4	Study	Study	NNP
cord-290566-tmsocyfc	179	5	found	find	VBD
cord-290566-tmsocyfc	179	6	no	no	DT
cord-290566-tmsocyfc	179	7	association	association	NN
cord-290566-tmsocyfc	179	8	of	of	IN
cord-290566-tmsocyfc	179	9	CTLA-4	CTLA-4	NNP
cord-290566-tmsocyfc	179	10	polymorphisms	polymorphism	NNS
cord-290566-tmsocyfc	179	11	with	with	IN
cord-290566-tmsocyfc	179	12	the	the	DT
cord-290566-tmsocyfc	179	13	disease	disease	NN
cord-290566-tmsocyfc	179	14	course	course	NN
cord-290566-tmsocyfc	179	15	of	of	IN
cord-290566-tmsocyfc	179	16	MS	MS	NNP
cord-290566-tmsocyfc	179	17	(	(	-LRB-
cord-290566-tmsocyfc	179	18	Dyment	Dyment	NNP
cord-290566-tmsocyfc	179	19	et	et	NNP
cord-290566-tmsocyfc	179	20	al	al	NNP
cord-290566-tmsocyfc	179	21	.	.	NNP
cord-290566-tmsocyfc	179	22	,	,	,
cord-290566-tmsocyfc	179	23	2002	2002	CD
cord-290566-tmsocyfc	179	24	)	)	-RRB-
cord-290566-tmsocyfc	179	25	.	.	.
cord-290566-tmsocyfc	180	1	The	the	DT
cord-290566-tmsocyfc	180	2	exon	exon	NN
cord-290566-tmsocyfc	180	3	1	1	CD
cord-290566-tmsocyfc	180	4	A	a	NN
cord-290566-tmsocyfc	180	5	/	/	SYM
cord-290566-tmsocyfc	180	6	G	g	NN
cord-290566-tmsocyfc	180	7	polymorphism	polymorphism	NN
cord-290566-tmsocyfc	180	8	was	be	VBD
cord-290566-tmsocyfc	180	9	associated	associate	VBN
cord-290566-tmsocyfc	180	10	with	with	IN
cord-290566-tmsocyfc	180	11	the	the	DT
cord-290566-tmsocyfc	180	12	presence	presence	NN
cord-290566-tmsocyfc	180	13	of	of	IN
cord-290566-tmsocyfc	180	14	oligoclonal	oligoclonal	JJ
cord-290566-tmsocyfc	180	15	bands	band	NNS
cord-290566-tmsocyfc	180	16	in	in	IN
cord-290566-tmsocyfc	180	17	the	the	DT
cord-290566-tmsocyfc	180	18	CSF	CSF	NNP
cord-290566-tmsocyfc	180	19	(	(	-LRB-
cord-290566-tmsocyfc	180	20	Fukazawa	Fukazawa	NNP
cord-290566-tmsocyfc	180	21	et	et	NNP
cord-290566-tmsocyfc	180	22	al	al	NNP
cord-290566-tmsocyfc	180	23	.	.	NNP
cord-290566-tmsocyfc	180	24	,	,	,
cord-290566-tmsocyfc	180	25	1999	1999	CD
cord-290566-tmsocyfc	180	26	)	)	-RRB-
cord-290566-tmsocyfc	180	27	.	.	.
cord-290566-tmsocyfc	181	1	Thus	thus	RB
cord-290566-tmsocyfc	181	2	,	,	,
cord-290566-tmsocyfc	181	3	dysregulation	dysregulation	NN
cord-290566-tmsocyfc	181	4	of	of	IN
cord-290566-tmsocyfc	181	5	CTLA-4	CTLA-4	NNS
cord-290566-tmsocyfc	181	6	signaling	signal	VBG
cord-290566-tmsocyfc	181	7	may	may	MD
cord-290566-tmsocyfc	181	8	contribute	contribute	VB
cord-290566-tmsocyfc	181	9	to	to	IN
cord-290566-tmsocyfc	181	10	susceptibility	susceptibility	NN
cord-290566-tmsocyfc	181	11	to	to	IN
cord-290566-tmsocyfc	181	12	MS	MS	NNP
cord-290566-tmsocyfc	181	13	.	.	.
cord-290566-tmsocyfc	182	1	A	a	DT
cord-290566-tmsocyfc	182	2	phase	phase	NN
cord-290566-tmsocyfc	182	3	I	-PRON-	PRP
cord-290566-tmsocyfc	182	4	safety	safety	NN
cord-290566-tmsocyfc	182	5	study	study	NN
cord-290566-tmsocyfc	182	6	of	of	IN
cord-290566-tmsocyfc	182	7	CTLA4Ig	CTLA4Ig	NNP
cord-290566-tmsocyfc	183	1	(	(	-LRB-
cord-290566-tmsocyfc	183	2	Repligen	Repligen	NNP
cord-290566-tmsocyfc	183	3	-	-	HYPH
cord-290566-tmsocyfc	183	4	RG2077	rg2077	NN
cord-290566-tmsocyfc	183	5	)	)	-RRB-
cord-290566-tmsocyfc	183	6	as	as	RB
cord-290566-tmsocyfc	183	7	well	well	RB
cord-290566-tmsocyfc	183	8	as	as	IN
cord-290566-tmsocyfc	183	9	a	a	DT
cord-290566-tmsocyfc	183	10	multicenter	multicenter	JJ
cord-290566-tmsocyfc	183	11	study	study	NN
cord-290566-tmsocyfc	183	12	of	of	IN
cord-290566-tmsocyfc	183	13	CTLA4Ig	CTLA4Ig	NNP
cord-290566-tmsocyfc	183	14	(	(	-LRB-
cord-290566-tmsocyfc	183	15	BMS-188667	BMS-188667	NNP
cord-290566-tmsocyfc	183	16	)	)	-RRB-
cord-290566-tmsocyfc	183	17	for	for	IN
cord-290566-tmsocyfc	183	18	MS	MS	NNP
cord-290566-tmsocyfc	183	19	are	be	VBP
cord-290566-tmsocyfc	183	20	ongoing	ongoing	JJ
cord-290566-tmsocyfc	183	21	.	.	.
cord-290566-tmsocyfc	184	1	Interaction	Interaction	NNP
cord-290566-tmsocyfc	184	2	of	of	IN
cord-290566-tmsocyfc	184	3	CD40	CD40	NNP
cord-290566-tmsocyfc	184	4	on	on	IN
cord-290566-tmsocyfc	184	5	APCs	apc	NNS
cord-290566-tmsocyfc	184	6	with	with	IN
cord-290566-tmsocyfc	184	7	CD154	CD154	NNP
cord-290566-tmsocyfc	184	8	on	on	IN
cord-290566-tmsocyfc	184	9	T	T	NNP
cord-290566-tmsocyfc	184	10	cells	cell	NNS
cord-290566-tmsocyfc	184	11	induces	induce	VBZ
cord-290566-tmsocyfc	184	12	APC	APC	NNP
cord-290566-tmsocyfc	184	13	production	production	NN
cord-290566-tmsocyfc	184	14	of	of	IN
cord-290566-tmsocyfc	184	15	IL-12	IL-12	NNP
cord-290566-tmsocyfc	184	16	,	,	,
cord-290566-tmsocyfc	184	17	a	a	DT
cord-290566-tmsocyfc	184	18	major	major	JJ
cord-290566-tmsocyfc	184	19	factor	factor	NN
cord-290566-tmsocyfc	184	20	in	in	IN
cord-290566-tmsocyfc	184	21	Th1	th1	CD
cord-290566-tmsocyfc	184	22	cell	cell	NN
cord-290566-tmsocyfc	184	23	diVerentiation	diverentiation	NN
cord-290566-tmsocyfc	184	24	(	(	-LRB-
cord-290566-tmsocyfc	184	25	Kelsall	Kelsall	NNP
cord-290566-tmsocyfc	184	26	et	et	FW
cord-290566-tmsocyfc	184	27	al	al	NNP
cord-290566-tmsocyfc	184	28	.	.	NNP
cord-290566-tmsocyfc	184	29	,	,	,
cord-290566-tmsocyfc	184	30	1996	1996	CD
cord-290566-tmsocyfc	184	31	)	)	-RRB-
cord-290566-tmsocyfc	184	32	.	.	.
cord-290566-tmsocyfc	185	1	Expression	expression	NN
cord-290566-tmsocyfc	185	2	of	of	IN
cord-290566-tmsocyfc	185	3	both	both	DT
cord-290566-tmsocyfc	185	4	CD40	CD40	NNP
cord-290566-tmsocyfc	185	5	and	and	CC
cord-290566-tmsocyfc	185	6	CD154	CD154	NNP
cord-290566-tmsocyfc	185	7	were	be	VBD
cord-290566-tmsocyfc	185	8	increased	increase	VBN
cord-290566-tmsocyfc	185	9	in	in	IN
cord-290566-tmsocyfc	185	10	lesions	lesion	NNS
cord-290566-tmsocyfc	185	11	from	from	IN
cord-290566-tmsocyfc	185	12	postmortem	postmortem	JJ
cord-290566-tmsocyfc	185	13	MS	MS	NNP
cord-290566-tmsocyfc	185	14	brains	brain	NNS
cord-290566-tmsocyfc	185	15	compared	compare	VBN
cord-290566-tmsocyfc	185	16	with	with	IN
cord-290566-tmsocyfc	185	17	controls	control	NNS
cord-290566-tmsocyfc	185	18	,	,	,
cord-290566-tmsocyfc	185	19	with	with	IN
cord-290566-tmsocyfc	185	20	CD40	CD40	NNP
cord-290566-tmsocyfc	185	21	found	find	VBD
cord-290566-tmsocyfc	185	22	predominantly	predominantly	RB
cord-290566-tmsocyfc	185	23	on	on	IN
cord-290566-tmsocyfc	185	24	macrophages	macrophage	NNS
cord-290566-tmsocyfc	185	25	and	and	CC
cord-290566-tmsocyfc	185	26	microglia	microglia	NN
cord-290566-tmsocyfc	185	27	,	,	,
cord-290566-tmsocyfc	185	28	while	while	IN
cord-290566-tmsocyfc	185	29	CD154	cd154	XX
cord-290566-tmsocyfc	185	30	colocalized	colocalize	VBN
cord-290566-tmsocyfc	185	31	with	with	IN
cord-290566-tmsocyfc	185	32	the	the	DT
cord-290566-tmsocyfc	185	33	CD4	CD4	NNP
cord-290566-tmsocyfc	185	34	T	T	NNP
cord-290566-tmsocyfc	185	35	-	-	HYPH
cord-290566-tmsocyfc	185	36	cell	cell	NN
cord-290566-tmsocyfc	185	37	marker	marker	NN
cord-290566-tmsocyfc	185	38	(	(	-LRB-
cord-290566-tmsocyfc	185	39	Gerritse	Gerritse	NNP
cord-290566-tmsocyfc	185	40	et	et	NNP
cord-290566-tmsocyfc	185	41	al	al	NNP
cord-290566-tmsocyfc	185	42	.	.	NNP
cord-290566-tmsocyfc	185	43	,	,	,
cord-290566-tmsocyfc	185	44	1996	1996	CD
cord-290566-tmsocyfc	185	45	)	)	-RRB-
cord-290566-tmsocyfc	185	46	.	.	.
cord-290566-tmsocyfc	186	1	Expression	expression	NN
cord-290566-tmsocyfc	186	2	of	of	IN
cord-290566-tmsocyfc	186	3	CD154	CD154	NNP
cord-290566-tmsocyfc	186	4	was	be	VBD
cord-290566-tmsocyfc	186	5	found	find	VBN
cord-290566-tmsocyfc	186	6	to	to	TO
cord-290566-tmsocyfc	186	7	be	be	VB
cord-290566-tmsocyfc	186	8	higher	high	JJR
cord-290566-tmsocyfc	186	9	in	in	IN
cord-290566-tmsocyfc	186	10	peripheral	peripheral	JJ
cord-290566-tmsocyfc	186	11	blood	blood	NN
cord-290566-tmsocyfc	186	12	monocytes	monocyte	NNS
cord-290566-tmsocyfc	186	13	isolated	isolate	VBN
cord-290566-tmsocyfc	186	14	from	from	IN
cord-290566-tmsocyfc	186	15	SPMS	SPMS	NNP
cord-290566-tmsocyfc	186	16	compared	compare	VBN
cord-290566-tmsocyfc	186	17	with	with	IN
cord-290566-tmsocyfc	186	18	RRMS	RRMS	NNP
cord-290566-tmsocyfc	186	19	or	or	CC
cord-290566-tmsocyfc	186	20	THE	the	DT
cord-290566-tmsocyfc	186	21	ROLE	role	NN
cord-290566-tmsocyfc	186	22	OF	of	IN
cord-290566-tmsocyfc	186	23	CD4	CD4	NNP
cord-290566-tmsocyfc	186	24	T	T	NNP
cord-290566-tmsocyfc	186	25	CELLS	cell	VBN
cord-290566-tmsocyfc	186	26	IN	in	IN
cord-290566-tmsocyfc	186	27	THE	the	DT
cord-290566-tmsocyfc	186	28	PATHOGENESIS	PATHOGENESIS	NNP
cord-290566-tmsocyfc	186	29	healthy	healthy	JJ
cord-290566-tmsocyfc	186	30	controls	control	NNS
cord-290566-tmsocyfc	186	31	(	(	-LRB-
cord-290566-tmsocyfc	186	32	Filion	Filion	NNP
cord-290566-tmsocyfc	186	33	et	et	NNP
cord-290566-tmsocyfc	186	34	al	al	NNP
cord-290566-tmsocyfc	186	35	.	.	NNP
cord-290566-tmsocyfc	186	36	,	,	,
cord-290566-tmsocyfc	186	37	2003	2003	CD
cord-290566-tmsocyfc	186	38	;	;	:
cord-290566-tmsocyfc	186	39	Jensen	Jensen	NNP
cord-290566-tmsocyfc	186	40	et	et	NNP
cord-290566-tmsocyfc	186	41	al	al	NNP
cord-290566-tmsocyfc	186	42	.	.	NNP
cord-290566-tmsocyfc	186	43	,	,	,
cord-290566-tmsocyfc	186	44	2001	2001	CD
cord-290566-tmsocyfc	186	45	)	)	-RRB-
cord-290566-tmsocyfc	186	46	,	,	,
cord-290566-tmsocyfc	186	47	and	and	CC
cord-290566-tmsocyfc	186	48	was	be	VBD
cord-290566-tmsocyfc	186	49	reduced	reduce	VBN
cord-290566-tmsocyfc	186	50	by	by	IN
cord-290566-tmsocyfc	186	51	IFN	IFN	NNP
cord-290566-tmsocyfc	186	52	-	-	HYPH
cord-290566-tmsocyfc	186	53	treatment	treatment	NN
cord-290566-tmsocyfc	186	54	(	(	-LRB-
cord-290566-tmsocyfc	186	55	Teleshova	Teleshova	NNP
cord-290566-tmsocyfc	186	56	et	et	FW
cord-290566-tmsocyfc	186	57	al	al	NNP
cord-290566-tmsocyfc	186	58	.	.	NNP
cord-290566-tmsocyfc	186	59	,	,	,
cord-290566-tmsocyfc	186	60	2000	2000	CD
cord-290566-tmsocyfc	186	61	)	)	-RRB-
cord-290566-tmsocyfc	186	62	.	.	.
cord-290566-tmsocyfc	187	1	PBMCs	pbmc	NNS
cord-290566-tmsocyfc	187	2	from	from	IN
cord-290566-tmsocyfc	187	3	SPMS	SPMS	NNP
cord-290566-tmsocyfc	187	4	patients	patient	NNS
cord-290566-tmsocyfc	187	5	produced	produce	VBD
cord-290566-tmsocyfc	187	6	more	more	JJR
cord-290566-tmsocyfc	187	7	IL-12	IL-12	NNP
cord-290566-tmsocyfc	187	8	and	and	CC
cord-290566-tmsocyfc	187	9	IFN	IFN	NNP
cord-290566-tmsocyfc	187	10	-	-	,
cord-290566-tmsocyfc	187	11	when	when	WRB
cord-290566-tmsocyfc	187	12	restimulated	restimulate	VBN
cord-290566-tmsocyfc	187	13	in	in	IN
cord-290566-tmsocyfc	187	14	vitro	vitro	FW
cord-290566-tmsocyfc	187	15	,	,	,
cord-290566-tmsocyfc	187	16	compared	compare	VBN
cord-290566-tmsocyfc	187	17	with	with	IN
cord-290566-tmsocyfc	187	18	healthy	healthy	JJ
cord-290566-tmsocyfc	187	19	controls	control	NNS
cord-290566-tmsocyfc	187	20	(	(	-LRB-
cord-290566-tmsocyfc	187	21	Karni	Karni	NNP
cord-290566-tmsocyfc	187	22	et	et	FW
cord-290566-tmsocyfc	187	23	al	al	NNP
cord-290566-tmsocyfc	187	24	.	.	NNP
cord-290566-tmsocyfc	187	25	,	,	,
cord-290566-tmsocyfc	187	26	2002	2002	CD
cord-290566-tmsocyfc	187	27	)	)	-RRB-
cord-290566-tmsocyfc	187	28	.	.	.
cord-290566-tmsocyfc	188	1	In	in	IN
cord-290566-tmsocyfc	188	2	summary	summary	NN
cord-290566-tmsocyfc	188	3	,	,	,
cord-290566-tmsocyfc	188	4	these	these	DT
cord-290566-tmsocyfc	188	5	studies	study	NNS
cord-290566-tmsocyfc	188	6	indicate	indicate	VBP
cord-290566-tmsocyfc	188	7	that	that	IN
cord-290566-tmsocyfc	188	8	the	the	DT
cord-290566-tmsocyfc	188	9	CD40-CD154	CD40-CD154	NNP
cord-290566-tmsocyfc	188	10	pathway	pathway	NN
cord-290566-tmsocyfc	188	11	is	be	VBZ
cord-290566-tmsocyfc	188	12	important	important	JJ
cord-290566-tmsocyfc	188	13	for	for	IN
cord-290566-tmsocyfc	188	14	the	the	DT
cord-290566-tmsocyfc	188	15	regulation	regulation	NN
cord-290566-tmsocyfc	188	16	of	of	IN
cord-290566-tmsocyfc	188	17	Th1	th1	CD
cord-290566-tmsocyfc	188	18	cytokine	cytokine	NN
cord-290566-tmsocyfc	188	19	production	production	NN
cord-290566-tmsocyfc	188	20	in	in	IN
cord-290566-tmsocyfc	188	21	MS	MS	NNP
cord-290566-tmsocyfc	188	22	.	.	.
cord-290566-tmsocyfc	189	1	Clinical	clinical	JJ
cord-290566-tmsocyfc	189	2	trials	trial	NNS
cord-290566-tmsocyfc	189	3	with	with	IN
cord-290566-tmsocyfc	189	4	an	an	DT
cord-290566-tmsocyfc	189	5	anti	anti	JJ
cord-290566-tmsocyfc	189	6	-	-	JJ
cord-290566-tmsocyfc	189	7	CD154	cd154	JJ
cord-290566-tmsocyfc	189	8	antibody	antibody	NN
cord-290566-tmsocyfc	189	9	(	(	-LRB-
cord-290566-tmsocyfc	189	10	Biogen	Biogen	NNP
cord-290566-tmsocyfc	189	11	)	)	-RRB-
cord-290566-tmsocyfc	189	12	in	in	IN
cord-290566-tmsocyfc	189	13	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	189	14	disease	disease	NN
cord-290566-tmsocyfc	189	15	such	such	JJ
cord-290566-tmsocyfc	189	16	as	as	IN
cord-290566-tmsocyfc	189	17	ITP	ITP	NNP
cord-290566-tmsocyfc	189	18	and	and	CC
cord-290566-tmsocyfc	189	19	lupus	lupus	NN
cord-290566-tmsocyfc	189	20	were	be	VBD
cord-290566-tmsocyfc	189	21	terminated	terminate	VBN
cord-290566-tmsocyfc	189	22	because	because	IN
cord-290566-tmsocyfc	189	23	of	of	IN
cord-290566-tmsocyfc	189	24	the	the	DT
cord-290566-tmsocyfc	189	25	occurrence	occurrence	NN
cord-290566-tmsocyfc	189	26	of	of	IN
cord-290566-tmsocyfc	189	27	thromboembolic	thromboembolic	JJ
cord-290566-tmsocyfc	189	28	events	event	NNS
cord-290566-tmsocyfc	189	29	.	.	.
cord-290566-tmsocyfc	190	1	Another	another	DT
cord-290566-tmsocyfc	190	2	formulation	formulation	NN
cord-290566-tmsocyfc	190	3	of	of	IN
cord-290566-tmsocyfc	190	4	the	the	DT
cord-290566-tmsocyfc	190	5	antibody	antibody	NN
cord-290566-tmsocyfc	190	6	(	(	-LRB-
cord-290566-tmsocyfc	190	7	IDEC	IDEC	NNP
cord-290566-tmsocyfc	190	8	pharmaceuticals	pharmaceutical	NNS
cord-290566-tmsocyfc	190	9	)	)	-RRB-
cord-290566-tmsocyfc	190	10	is	be	VBZ
cord-290566-tmsocyfc	190	11	under	under	IN
cord-290566-tmsocyfc	190	12	investigation	investigation	NN
cord-290566-tmsocyfc	190	13	.	.	.
cord-290566-tmsocyfc	191	1	A	a	DT
cord-290566-tmsocyfc	191	2	phase	phase	NN
cord-290566-tmsocyfc	191	3	I	-PRON-	PRP
cord-290566-tmsocyfc	191	4	clinical	clinical	JJ
cord-290566-tmsocyfc	191	5	trial	trial	NN
cord-290566-tmsocyfc	191	6	in	in	IN
cord-290566-tmsocyfc	191	7	MS	MS	NNP
cord-290566-tmsocyfc	191	8	patients	patient	NNS
cord-290566-tmsocyfc	191	9	was	be	VBD
cord-290566-tmsocyfc	191	10	recently	recently	RB
cord-290566-tmsocyfc	191	11	performed	perform	VBN
cord-290566-tmsocyfc	191	12	with	with	IN
cord-290566-tmsocyfc	191	13	good	good	JJ
cord-290566-tmsocyfc	191	14	safety	safety	NN
cord-290566-tmsocyfc	191	15	data	datum	NNS
cord-290566-tmsocyfc	191	16	,	,	,
cord-290566-tmsocyfc	191	17	and	and	CC
cord-290566-tmsocyfc	191	18	therapeutic	therapeutic	JJ
cord-290566-tmsocyfc	191	19	eVects	evect	NNS
cord-290566-tmsocyfc	191	20	are	be	VBP
cord-290566-tmsocyfc	191	21	currently	currently	RB
cord-290566-tmsocyfc	191	22	under	under	IN
cord-290566-tmsocyfc	191	23	investigation	investigation	NN
cord-290566-tmsocyfc	191	24	.	.	.
cord-290566-tmsocyfc	192	1	Programmed	program	VBN
cord-290566-tmsocyfc	192	2	death-1	death-1	NNP
cord-290566-tmsocyfc	192	3	(	(	-LRB-
cord-290566-tmsocyfc	192	4	PD-1	PD-1	NNP
cord-290566-tmsocyfc	192	5	)	)	-RRB-
cord-290566-tmsocyfc	192	6	is	be	VBZ
cord-290566-tmsocyfc	192	7	expressed	express	VBN
cord-290566-tmsocyfc	192	8	on	on	IN
cord-290566-tmsocyfc	192	9	T	T	NNP
cord-290566-tmsocyfc	192	10	cells	cell	NNS
cord-290566-tmsocyfc	192	11	and	and	CC
cord-290566-tmsocyfc	192	12	is	be	VBZ
cord-290566-tmsocyfc	192	13	a	a	DT
cord-290566-tmsocyfc	192	14	negative	negative	JJ
cord-290566-tmsocyfc	192	15	regulator	regulator	NN
cord-290566-tmsocyfc	192	16	of	of	IN
cord-290566-tmsocyfc	192	17	T	t	NN
cord-290566-tmsocyfc	192	18	-	-	HYPH
cord-290566-tmsocyfc	192	19	cell	cell	NN
cord-290566-tmsocyfc	192	20	activation	activation	NN
cord-290566-tmsocyfc	192	21	.	.	.
cord-290566-tmsocyfc	193	1	PD-1	pd-1	DT
cord-290566-tmsocyfc	193	2	polymorphism	polymorphism	NN
cord-290566-tmsocyfc	193	3	was	be	VBD
cord-290566-tmsocyfc	193	4	shown	show	VBN
cord-290566-tmsocyfc	193	5	to	to	TO
cord-290566-tmsocyfc	193	6	be	be	VB
cord-290566-tmsocyfc	193	7	a	a	DT
cord-290566-tmsocyfc	193	8	genetic	genetic	JJ
cord-290566-tmsocyfc	193	9	modifier	modifier	NN
cord-290566-tmsocyfc	193	10	of	of	IN
cord-290566-tmsocyfc	193	11	the	the	DT
cord-290566-tmsocyfc	193	12	progression	progression	NN
cord-290566-tmsocyfc	193	13	of	of	IN
cord-290566-tmsocyfc	193	14	MS	MS	NNP
cord-290566-tmsocyfc	193	15	,	,	,
cord-290566-tmsocyfc	193	16	and	and	CC
cord-290566-tmsocyfc	193	17	this	this	DT
cord-290566-tmsocyfc	193	18	may	may	MD
cord-290566-tmsocyfc	193	19	relate	relate	VB
cord-290566-tmsocyfc	193	20	to	to	IN
cord-290566-tmsocyfc	193	21	PD-1-mediated	pd-1-mediate	VBN
cord-290566-tmsocyfc	193	22	inhibition	inhibition	NN
cord-290566-tmsocyfc	193	23	of	of	IN
cord-290566-tmsocyfc	193	24	T	t	NN
cord-290566-tmsocyfc	193	25	-	-	HYPH
cord-290566-tmsocyfc	193	26	cell	cell	NN
cord-290566-tmsocyfc	193	27	activation	activation	NN
cord-290566-tmsocyfc	193	28	(	(	-LRB-
cord-290566-tmsocyfc	193	29	Kroner	Kroner	NNP
cord-290566-tmsocyfc	193	30	et	et	FW
cord-290566-tmsocyfc	193	31	al	al	NNP
cord-290566-tmsocyfc	193	32	.	.	NNP
cord-290566-tmsocyfc	193	33	,	,	,
cord-290566-tmsocyfc	193	34	2005	2005	CD
cord-290566-tmsocyfc	193	35	)	)	-RRB-
cord-290566-tmsocyfc	193	36	.	.	.
cord-290566-tmsocyfc	194	1	The	the	DT
cord-290566-tmsocyfc	194	2	Tim	Tim	NNP
cord-290566-tmsocyfc	194	3	family	family	NN
cord-290566-tmsocyfc	194	4	of	of	IN
cord-290566-tmsocyfc	194	5	molecules	molecule	NNS
cord-290566-tmsocyfc	194	6	are	be	VBP
cord-290566-tmsocyfc	194	7	important	important	JJ
cord-290566-tmsocyfc	194	8	cell	cell	NN
cord-290566-tmsocyfc	194	9	-	-	HYPH
cord-290566-tmsocyfc	194	10	surface	surface	NN
cord-290566-tmsocyfc	194	11	markers	marker	NNS
cord-290566-tmsocyfc	194	12	as	as	RB
cord-290566-tmsocyfc	194	13	well	well	RB
cord-290566-tmsocyfc	194	14	as	as	IN
cord-290566-tmsocyfc	194	15	costimulatory	costimulatory	NN
cord-290566-tmsocyfc	194	16	regulators	regulator	NNS
cord-290566-tmsocyfc	194	17	of	of	IN
cord-290566-tmsocyfc	194	18	Th1	th1	CD
cord-290566-tmsocyfc	194	19	/	/	SYM
cord-290566-tmsocyfc	194	20	Th2	th2	CD
cord-290566-tmsocyfc	194	21	responses	response	NNS
cord-290566-tmsocyfc	194	22	.	.	.
cord-290566-tmsocyfc	195	1	In	in	IN
cord-290566-tmsocyfc	195	2	MS	MS	NNP
cord-290566-tmsocyfc	195	3	patients	patient	NNS
cord-290566-tmsocyfc	195	4	,	,	,
cord-290566-tmsocyfc	195	5	CSF	CSF	NNP
cord-290566-tmsocyfc	195	6	T	T	NNP
cord-290566-tmsocyfc	195	7	-	-	HYPH
cord-290566-tmsocyfc	195	8	cell	cell	NN
cord-290566-tmsocyfc	195	9	clones	clone	NNS
cord-290566-tmsocyfc	195	10	demonstrated	demonstrate	VBD
cord-290566-tmsocyfc	195	11	reduced	reduced	JJ
cord-290566-tmsocyfc	195	12	levels	level	NNS
cord-290566-tmsocyfc	195	13	of	of	IN
cord-290566-tmsocyfc	195	14	Tim-3	Tim-3	NNP
cord-290566-tmsocyfc	195	15	and	and	CC
cord-290566-tmsocyfc	195	16	T	T	NNP
cord-290566-tmsocyfc	195	17	-	-	HYPH
cord-290566-tmsocyfc	195	18	bet	bet	NN
cord-290566-tmsocyfc	195	19	and	and	CC
cord-290566-tmsocyfc	195	20	secreted	secrete	VBD
cord-290566-tmsocyfc	195	21	higher	high	JJR
cord-290566-tmsocyfc	195	22	amounts	amount	NNS
cord-290566-tmsocyfc	195	23	of	of	IN
cord-290566-tmsocyfc	195	24	IFN	IFN	NNP
cord-290566-tmsocyfc	195	25	-	-	:
cord-290566-tmsocyfc	195	26	than	than	IN
cord-290566-tmsocyfc	195	27	did	do	VBD
cord-290566-tmsocyfc	195	28	those	those	DT
cord-290566-tmsocyfc	195	29	from	from	IN
cord-290566-tmsocyfc	195	30	control	control	NN
cord-290566-tmsocyfc	195	31	subjects	subject	NNS
cord-290566-tmsocyfc	195	32	,	,	,
cord-290566-tmsocyfc	195	33	indicating	indicate	VBG
cord-290566-tmsocyfc	195	34	that	that	IN
cord-290566-tmsocyfc	195	35	Tim-3	Tim-3	NNP
cord-290566-tmsocyfc	195	36	may	may	MD
cord-290566-tmsocyfc	195	37	represent	represent	VB
cord-290566-tmsocyfc	195	38	an	an	DT
cord-290566-tmsocyfc	195	39	important	important	JJ
cord-290566-tmsocyfc	195	40	regulator	regulator	NN
cord-290566-tmsocyfc	195	41	of	of	IN
cord-290566-tmsocyfc	195	42	Th1	th1	NN
cord-290566-tmsocyfc	195	43	responses	response	NNS
cord-290566-tmsocyfc	195	44	in	in	IN
cord-290566-tmsocyfc	195	45	MS	MS	NNP
cord-290566-tmsocyfc	195	46	(	(	-LRB-
cord-290566-tmsocyfc	195	47	Koguchi	Koguchi	NNP
cord-290566-tmsocyfc	195	48	et	et	NNP
cord-290566-tmsocyfc	195	49	al	al	NNP
cord-290566-tmsocyfc	195	50	.	.	NNP
cord-290566-tmsocyfc	195	51	,	,	,
cord-290566-tmsocyfc	195	52	2006	2006	CD
cord-290566-tmsocyfc	195	53	)	)	-RRB-
cord-290566-tmsocyfc	195	54	.	.	.
cord-290566-tmsocyfc	196	1	In	in	IN
cord-290566-tmsocyfc	196	2	summary	summary	NN
cord-290566-tmsocyfc	196	3	,	,	,
cord-290566-tmsocyfc	196	4	there	there	EX
cord-290566-tmsocyfc	196	5	is	be	VBZ
cord-290566-tmsocyfc	196	6	significant	significant	JJ
cord-290566-tmsocyfc	196	7	evidence	evidence	NN
cord-290566-tmsocyfc	196	8	that	that	IN
cord-290566-tmsocyfc	196	9	costimulatory	costimulatory	NN
cord-290566-tmsocyfc	196	10	molecules	molecule	NNS
cord-290566-tmsocyfc	196	11	represent	represent	VBP
cord-290566-tmsocyfc	196	12	an	an	DT
cord-290566-tmsocyfc	196	13	important	important	JJ
cord-290566-tmsocyfc	196	14	step	step	NN
cord-290566-tmsocyfc	196	15	in	in	IN
cord-290566-tmsocyfc	196	16	the	the	DT
cord-290566-tmsocyfc	196	17	control	control	NN
cord-290566-tmsocyfc	196	18	of	of	IN
cord-290566-tmsocyfc	196	19	T	t	NN
cord-290566-tmsocyfc	196	20	-	-	HYPH
cord-290566-tmsocyfc	196	21	cell	cell	NN
cord-290566-tmsocyfc	196	22	activation	activation	NN
cord-290566-tmsocyfc	196	23	in	in	IN
cord-290566-tmsocyfc	196	24	MS	MS	NNP
cord-290566-tmsocyfc	196	25	and	and	CC
cord-290566-tmsocyfc	196	26	are	be	VBP
cord-290566-tmsocyfc	196	27	viable	viable	JJ
cord-290566-tmsocyfc	196	28	therapeutic	therapeutic	JJ
cord-290566-tmsocyfc	196	29	targets	target	NNS
cord-290566-tmsocyfc	196	30	.	.	.
cord-290566-tmsocyfc	197	1	In	in	IN
cord-290566-tmsocyfc	197	2	the	the	DT
cord-290566-tmsocyfc	197	3	context	context	NN
cord-290566-tmsocyfc	197	4	of	of	IN
cord-290566-tmsocyfc	197	5	MS	MS	NNP
cord-290566-tmsocyfc	197	6	,	,	,
cord-290566-tmsocyfc	197	7	Th1	th1	NN
cord-290566-tmsocyfc	197	8	cytokines	cytokine	NNS
cord-290566-tmsocyfc	197	9	are	be	VBP
cord-290566-tmsocyfc	197	10	thought	think	VBN
cord-290566-tmsocyfc	197	11	to	to	TO
cord-290566-tmsocyfc	197	12	mediate	mediate	VB
cord-290566-tmsocyfc	197	13	disease	disease	NN
cord-290566-tmsocyfc	197	14	,	,	,
cord-290566-tmsocyfc	197	15	while	while	IN
cord-290566-tmsocyfc	197	16	Th2	th2	CD
cord-290566-tmsocyfc	197	17	cytokines	cytokine	NNS
cord-290566-tmsocyfc	197	18	are	be	VBP
cord-290566-tmsocyfc	197	19	believed	believe	VBN
cord-290566-tmsocyfc	197	20	to	to	TO
cord-290566-tmsocyfc	197	21	play	play	VB
cord-290566-tmsocyfc	197	22	a	a	DT
cord-290566-tmsocyfc	197	23	protective	protective	JJ
cord-290566-tmsocyfc	197	24	role	role	NN
cord-290566-tmsocyfc	197	25	.	.	.
cord-290566-tmsocyfc	198	1	However	however	RB
cord-290566-tmsocyfc	198	2	,	,	,
cord-290566-tmsocyfc	198	3	as	as	IN
cord-290566-tmsocyfc	198	4	our	-PRON-	PRP$
cord-290566-tmsocyfc	198	5	understanding	understanding	NN
cord-290566-tmsocyfc	198	6	of	of	IN
cord-290566-tmsocyfc	198	7	the	the	DT
cord-290566-tmsocyfc	198	8	disease	disease	NN
cord-290566-tmsocyfc	198	9	evolves	evolve	VBZ
cord-290566-tmsocyfc	198	10	,	,	,
cord-290566-tmsocyfc	198	11	it	-PRON-	PRP
cord-290566-tmsocyfc	198	12	is	be	VBZ
cord-290566-tmsocyfc	198	13	clear	clear	JJ
cord-290566-tmsocyfc	198	14	that	that	IN
cord-290566-tmsocyfc	198	15	this	this	DT
cord-290566-tmsocyfc	198	16	paradigm	paradigm	NN
cord-290566-tmsocyfc	198	17	is	be	VBZ
cord-290566-tmsocyfc	198	18	not	not	RB
cord-290566-tmsocyfc	198	19	absolute	absolute	JJ
cord-290566-tmsocyfc	198	20	.	.	.
cord-290566-tmsocyfc	199	1	Moreover	moreover	RB
cord-290566-tmsocyfc	199	2	,	,	,
cord-290566-tmsocyfc	199	3	evidence	evidence	NN
cord-290566-tmsocyfc	199	4	of	of	IN
cord-290566-tmsocyfc	199	5	a	a	DT
cord-290566-tmsocyfc	199	6	distinct	distinct	JJ
cord-290566-tmsocyfc	199	7	lineage	lineage	NN
cord-290566-tmsocyfc	199	8	of	of	IN
cord-290566-tmsocyfc	199	9	Th17-producing	Th17-producing	NNP
cord-290566-tmsocyfc	199	10	T	T	NNP
cord-290566-tmsocyfc	199	11	cells	cell	NNS
cord-290566-tmsocyfc	199	12	has	have	VBZ
cord-290566-tmsocyfc	199	13	led	lead	VBN
cord-290566-tmsocyfc	199	14	to	to	IN
cord-290566-tmsocyfc	199	15	reevaluation	reevaluation	NN
cord-290566-tmsocyfc	199	16	of	of	IN
cord-290566-tmsocyfc	199	17	the	the	DT
cord-290566-tmsocyfc	199	18	role	role	NN
cord-290566-tmsocyfc	199	19	of	of	IN
cord-290566-tmsocyfc	199	20	Th1	Th1	NNP
cord-290566-tmsocyfc	199	21	cytokines	cytokine	NNS
cord-290566-tmsocyfc	199	22	in	in	IN
cord-290566-tmsocyfc	199	23	MS	MS	NNP
cord-290566-tmsocyfc	199	24	.	.	.
cord-290566-tmsocyfc	200	1	Th1	th1	NN
cord-290566-tmsocyfc	200	2	cytokines	cytokine	NNS
cord-290566-tmsocyfc	200	3	are	be	VBP
cord-290566-tmsocyfc	200	4	predominantly	predominantly	RB
cord-290566-tmsocyfc	200	5	found	find	VBN
cord-290566-tmsocyfc	200	6	in	in	IN
cord-290566-tmsocyfc	200	7	the	the	DT
cord-290566-tmsocyfc	200	8	brains	brain	NNS
cord-290566-tmsocyfc	200	9	of	of	IN
cord-290566-tmsocyfc	200	10	MS	MS	NNP
cord-290566-tmsocyfc	200	11	patients	patient	NNS
cord-290566-tmsocyfc	200	12	,	,	,
cord-290566-tmsocyfc	200	13	while	while	IN
cord-290566-tmsocyfc	200	14	a	a	DT
cord-290566-tmsocyfc	200	15	paucity	paucity	NN
cord-290566-tmsocyfc	200	16	of	of	IN
cord-290566-tmsocyfc	200	17	Th2	Th2	NNP
cord-290566-tmsocyfc	200	18	cytokines	cytokine	NNS
cord-290566-tmsocyfc	200	19	,	,	,
cord-290566-tmsocyfc	200	20	in	in	IN
cord-290566-tmsocyfc	200	21	particular	particular	JJ
cord-290566-tmsocyfc	200	22	TGF-	TGF-	NNP
cord-290566-tmsocyfc	200	23	,	,	,
cord-290566-tmsocyfc	200	24	and	and	CC
cord-290566-tmsocyfc	200	25	IL-10	IL-10	NNP
cord-290566-tmsocyfc	200	26	was	be	VBD
cord-290566-tmsocyfc	200	27	observed	observe	VBN
cord-290566-tmsocyfc	200	28	(	(	-LRB-
cord-290566-tmsocyfc	200	29	Cannel	Cannel	NNP
cord-290566-tmsocyfc	200	30	la	la	NNP
cord-290566-tmsocyfc	200	31	an	an	DT
cord-290566-tmsocyfc	200	32	d	d	NN
cord-290566-tmsocyfc	200	33	Rain	rain	NN
cord-290566-tmsocyfc	200	34	e	e	NN
cord-290566-tmsocyfc	200	35	,	,	,
cord-290566-tmsocyfc	200	36	1995	1995	CD
cord-290566-tmsocyfc	200	37	b	b	NN
cord-290566-tmsocyfc	200	38	;	;	:
cord-290566-tmsocyfc	200	39	Hofma	Hofma	NNP
cord-290566-tmsocyfc	200	40	n	n	NNP
cord-290566-tmsocyfc	200	41	et	et	NNP
cord-290566-tmsocyfc	200	42	al	al	NNP
cord-290566-tmsocyfc	200	43	.	.	NNP
cord-290566-tmsocyfc	200	44	,	,	,
cord-290566-tmsocyfc	200	45	1986	1986	CD
cord-290566-tmsocyfc	200	46	;	;	.
cord-290566-tmsocyfc	201	1	Woodroof	Woodroof	NNP
cord-290566-tmsocyfc	201	2	e	e	NN
cord-290566-tmsocyfc	201	3	and	and	CC
cord-290566-tmsocyfc	201	4	Cuzner	Cuzner	NNP
cord-290566-tmsocyfc	201	5	,	,	,
cord-290566-tmsocyfc	201	6	1993	1993	CD
cord-290566-tmsocyfc	201	7	)	)	-RRB-
cord-290566-tmsocyfc	201	8	.	.	.
cord-290566-tmsocyfc	202	1	Studies	study	NNS
cord-290566-tmsocyfc	202	2	using	use	VBG
cord-290566-tmsocyfc	202	3	semiquantitative	semiquantitative	JJ
cord-290566-tmsocyfc	202	4	RT	RT	NNP
cord-290566-tmsocyfc	202	5	-	-	HYPH
cord-290566-tmsocyfc	202	6	PCR	PCR	NNP
cord-290566-tmsocyfc	202	7	and	and	CC
cord-290566-tmsocyfc	202	8	immunocytochemistry	immunocytochemistry	NNP
cord-290566-tmsocyfc	202	9	found	find	VBD
cord-290566-tmsocyfc	202	10	increased	increased	JJ
cord-290566-tmsocyfc	202	11	expression	expression	NN
cord-290566-tmsocyfc	202	12	of	of	IN
cord-290566-tmsocyfc	202	13	B7	b7	NN
cord-290566-tmsocyfc	202	14	-	-	HYPH
cord-290566-tmsocyfc	202	15	1	1	CD
cord-290566-tmsocyfc	202	16	and	and	CC
cord-290566-tmsocyfc	202	17	IL12p40	il12p40	NN
cord-290566-tmsocyfc	202	18	in	in	IN
cord-290566-tmsocyfc	202	19	acute	acute	JJ
cord-290566-tmsocyfc	202	20	MS	MS	NNP
cord-290566-tmsocyfc	202	21	plaques	plaque	NNS
cord-290566-tmsocyfc	202	22	,	,	,
cord-290566-tmsocyfc	202	23	compared	compare	VBN
cord-290566-tmsocyfc	202	24	with	with	IN
cord-290566-tmsocyfc	202	25	samples	sample	NNS
cord-290566-tmsocyfc	202	26	isolated	isolate	VBN
cord-290566-tmsocyfc	202	27	from	from	IN
cord-290566-tmsocyfc	202	28	inflammatory	inflammatory	JJ
cord-290566-tmsocyfc	202	29	infarcts	infarct	NNS
cord-290566-tmsocyfc	202	30	(	(	-LRB-
cord-290566-tmsocyfc	202	31	Windhagen	Windhagen	NNP
cord-290566-tmsocyfc	202	32	et	et	NNP
cord-290566-tmsocyfc	202	33	al	al	NNP
cord-290566-tmsocyfc	202	34	.	.	NNP
cord-290566-tmsocyfc	202	35	,	,	,
cord-290566-tmsocyfc	202	36	1995	1995	CD
cord-290566-tmsocyfc	202	37	)	)	-RRB-
cord-290566-tmsocyfc	202	38	.	.	.
cord-290566-tmsocyfc	203	1	IL-6	IL-6	NNP
cord-290566-tmsocyfc	203	2	,	,	,
cord-290566-tmsocyfc	203	3	IFN-	IFN-	NNP
cord-290566-tmsocyfc	203	4	,	,	,
cord-290566-tmsocyfc	204	1	and	and	CC
cord-290566-tmsocyfc	204	2	TNF	TNF	NNP
cord-290566-tmsocyfc	204	3	-	-	,
cord-290566-tmsocyfc	204	4	were	be	VBD
cord-290566-tmsocyfc	204	5	expressed	express	VBN
cord-290566-tmsocyfc	204	6	by	by	IN
cord-290566-tmsocyfc	204	7	cells	cell	NNS
cord-290566-tmsocyfc	204	8	located	locate	VBN
cord-290566-tmsocyfc	204	9	in	in	IN
cord-290566-tmsocyfc	204	10	the	the	DT
cord-290566-tmsocyfc	204	11	perivascular	perivascular	NNP
cord-290566-tmsocyfc	204	12	cuVs	cuvs	NN
cord-290566-tmsocyfc	204	13	,	,	,
cord-290566-tmsocyfc	204	14	suggesting	suggest	VBG
cord-290566-tmsocyfc	204	15	that	that	IN
cord-290566-tmsocyfc	204	16	in	in	IN
cord-290566-tmsocyfc	204	17	acute	acute	JJ
cord-290566-tmsocyfc	204	18	MS	MS	NNP
cord-290566-tmsocyfc	204	19	lesions	lesion	NNS
cord-290566-tmsocyfc	204	20	,	,	,
cord-290566-tmsocyfc	204	21	inflammatory	inflammatory	JJ
cord-290566-tmsocyfc	204	22	cells	cell	NNS
cord-290566-tmsocyfc	204	23	are	be	VBP
cord-290566-tmsocyfc	204	24	the	the	DT
cord-290566-tmsocyfc	204	25	most	most	RBS
cord-290566-tmsocyfc	204	26	important	important	JJ
cord-290566-tmsocyfc	204	27	source	source	NN
cord-290566-tmsocyfc	204	28	of	of	IN
cord-290566-tmsocyfc	204	29	these	these	DT
cord-290566-tmsocyfc	204	30	cytokines	cytokine	NNS
cord-290566-tmsocyfc	204	31	(	(	-LRB-
cord-290566-tmsocyfc	204	32	Woodroofe	Woodroofe	NNP
cord-290566-tmsocyfc	204	33	and	and	CC
cord-290566-tmsocyfc	204	34	Cuzner	Cuzner	NNP
cord-290566-tmsocyfc	204	35	,	,	,
cord-290566-tmsocyfc	204	36	1993	1993	CD
cord-290566-tmsocyfc	204	37	)	)	-RRB-
cord-290566-tmsocyfc	204	38	.	.	.
cord-290566-tmsocyfc	205	1	Expression	expression	NN
cord-290566-tmsocyfc	205	2	of	of	IN
cord-290566-tmsocyfc	205	3	TNF	TNF	NNP
cord-290566-tmsocyfc	205	4	-	-	,
cord-290566-tmsocyfc	205	5	was	be	VBD
cord-290566-tmsocyfc	205	6	localized	localize	VBN
cord-290566-tmsocyfc	205	7	to	to	IN
cord-290566-tmsocyfc	205	8	macrop	macrop	NNP
cord-290566-tmsocyfc	205	9	hages	hages	NNP
cord-290566-tmsocyfc	205	10	,	,	,
cord-290566-tmsocyfc	205	11	microglia	microglia	NNP
cord-290566-tmsocyfc	205	12	,	,	,
cord-290566-tmsocyfc	205	13	and	and	CC
cord-290566-tmsocyfc	205	14	astrocyt	astrocyt	NNP
cord-290566-tmsocyfc	205	15	es	es	XX
cord-290566-tmsocyfc	205	16	(	(	-LRB-
cord-290566-tmsocyfc	205	17	Cannel	Cannel	NNP
cord-290566-tmsocyfc	205	18	la	la	NNP
cord-290566-tmsocyfc	205	19	and	and	CC
cord-290566-tmsocyfc	205	20	Rain	Rain	NNP
cord-290566-tmsocyfc	205	21	e	e	NNP
cord-290566-tmsocyfc	205	22	,	,	,
cord-290566-tmsocyfc	205	23	1995	1995	CD
cord-290566-tmsocyfc	205	24	b	b	NN
cord-290566-tmsocyfc	205	25	;	;	:
cord-290566-tmsocyfc	205	26	54	54	CD
cord-290566-tmsocyfc	205	27	TANUJA	TANUJA	NNP
cord-290566-tmsocyfc	205	28	CHITNIS	CHITNIS	NNP
cord-290566-tmsocyfc	205	29	Hofman	Hofman	NNP
cord-290566-tmsocyfc	205	30	et	et	NNP
cord-290566-tmsocyfc	205	31	al	al	NNP
cord-290566-tmsocyfc	205	32	.	.	NNP
cord-290566-tmsocyfc	205	33	,	,	,
cord-290566-tmsocyfc	205	34	1989	1989	CD
cord-290566-tmsocyfc	205	35	;	;	:
cord-290566-tmsocyfc	205	36	Selmaj	Selmaj	NNP
cord-290566-tmsocyfc	205	37	et	et	NNP
cord-290566-tmsocyfc	205	38	al	al	NNP
cord-290566-tmsocyfc	205	39	.	.	NNP
cord-290566-tmsocyfc	205	40	,	,	,
cord-290566-tmsocyfc	205	41	1991	1991	CD
cord-290566-tmsocyfc	205	42	)	)	-RRB-
cord-290566-tmsocyfc	205	43	in	in	IN
cord-290566-tmsocyfc	205	44	chronic	chronic	JJ
cord-290566-tmsocyfc	205	45	-	-	HYPH
cord-290566-tmsocyfc	205	46	active	active	JJ
cord-290566-tmsocyfc	205	47	lesions	lesion	NNS
cord-290566-tmsocyfc	205	48	.	.	.
cord-290566-tmsocyfc	206	1	A	a	DT
cord-290566-tmsocyfc	206	2	separate	separate	JJ
cord-290566-tmsocyfc	206	3	study	study	NN
cord-290566-tmsocyfc	206	4	found	find	VBD
cord-290566-tmsocyfc	206	5	that	that	IN
cord-290566-tmsocyfc	206	6	IL-2	IL-2	NNP
cord-290566-tmsocyfc	206	7	was	be	VBD
cord-290566-tmsocyfc	206	8	expressed	express	VBN
cord-290566-tmsocyfc	206	9	predominantly	predominantly	RB
cord-290566-tmsocyfc	206	10	in	in	IN
cord-290566-tmsocyfc	206	11	association	association	NN
cord-290566-tmsocyfc	206	12	with	with	IN
cord-290566-tmsocyfc	206	13	perivascular	perivascular	NNP
cord-290566-tmsocyfc	206	14	inflammatory	inflammatory	JJ
cord-290566-tmsocyfc	206	15	cells	cell	NNS
cord-290566-tmsocyfc	206	16	examining	examine	VBG
cord-290566-tmsocyfc	206	17	acute	acute	JJ
cord-290566-tmsocyfc	206	18	MS	MS	NNP
cord-290566-tmsocyfc	206	19	lesions	lesion	NNS
cord-290566-tmsocyfc	206	20	(	(	-LRB-
cord-290566-tmsocyfc	206	21	Hofman	Hofman	NNP
cord-290566-tmsocyfc	206	22	et	et	NNP
cord-290566-tmsocyfc	206	23	al	al	NNP
cord-290566-tmsocyfc	206	24	.	.	NNP
cord-290566-tmsocyfc	206	25	,	,	,
cord-290566-tmsocyfc	206	26	1986	1986	CD
cord-290566-tmsocyfc	206	27	)	)	-RRB-
cord-290566-tmsocyfc	206	28	.	.	.
cord-290566-tmsocyfc	207	1	Contrary	contrary	JJ
cord-290566-tmsocyfc	207	2	to	to	IN
cord-290566-tmsocyfc	207	3	the	the	DT
cord-290566-tmsocyfc	207	4	Th1	th1	CD
cord-290566-tmsocyfc	207	5	/	/	SYM
cord-290566-tmsocyfc	207	6	Th2	th2	CD
cord-290566-tmsocyfc	207	7	paradigm	paradigm	NN
cord-290566-tmsocyfc	207	8	of	of	IN
cord-290566-tmsocyfc	207	9	MS	MS	NNP
cord-290566-tmsocyfc	207	10	,	,	,
cord-290566-tmsocyfc	207	11	high	high	JJ
cord-290566-tmsocyfc	207	12	levels	level	NNS
cord-290566-tmsocyfc	207	13	of	of	IN
cord-290566-tmsocyfc	207	14	IL-4	IL-4	NNP
cord-290566-tmsocyfc	207	15	were	be	VBD
cord-290566-tmsocyfc	207	16	expressed	express	VBN
cord-290566-tmsocyfc	207	17	in	in	IN
cord-290566-tmsocyfc	207	18	both	both	DT
cord-290566-tmsocyfc	207	19	acute	acute	JJ
cord-290566-tmsocyfc	207	20	and	and	CC
cord-290566-tmsocyfc	207	21	chronic	chronic	JJ
cord-290566-tmsocyfc	207	22	-	-	HYPH
cord-290566-tmsocyfc	207	23	active	active	JJ
cord-290566-tmsocyfc	207	24	MS	MS	NNP
cord-290566-tmsocyfc	207	25	lesions	lesion	NNS
cord-290566-tmsocyfc	207	26	with	with	IN
cord-290566-tmsocyfc	207	27	no	no	DT
cord-290566-tmsocyfc	207	28	obvious	obvious	JJ
cord-290566-tmsocyfc	207	29	correlation	correlation	NN
cord-290566-tmsocyfc	207	30	to	to	IN
cord-290566-tmsocyfc	207	31	the	the	DT
cord-290566-tmsocyfc	207	32	resolution	resolution	NN
cord-290566-tmsocyfc	207	33	of	of	IN
cord-290566-tmsocyfc	207	34	the	the	DT
cord-290566-tmsocyfc	207	35	lesion	lesion	NN
cord-290566-tmsocyfc	207	36	(	(	-LRB-
cord-290566-tmsocyfc	207	37	Cannella	Cannella	NNP
cord-290566-tmsocyfc	207	38	and	and	CC
cord-290566-tmsocyfc	207	39	Raine	Raine	NNP
cord-290566-tmsocyfc	207	40	,	,	,
cord-290566-tmsocyfc	207	41	199	199	CD
cord-290566-tmsocyfc	207	42	5b	5b	CD
cord-290566-tmsocyfc	207	43	)	)	-RRB-
cord-290566-tmsocyfc	207	44	.	.	.
cord-290566-tmsocyfc	208	1	Studies	study	NNS
cord-290566-tmsocyfc	208	2	using	use	VBG
cord-290566-tmsocyfc	208	3	RN	RN	NNP
cord-290566-tmsocyfc	208	4	A	A	NNP
cord-290566-tmsocyfc	208	5	microarra	microarra	JJ
cord-290566-tmsocyfc	208	6	ys	ys	NNP
cord-290566-tmsocyfc	208	7	in	in	IN
cord-290566-tmsocyfc	208	8	MS	MS	NNP
cord-290566-tmsocyfc	208	9	brains	brain	NNS
cord-290566-tmsocyfc	208	10	at	at	IN
cord-290566-tmsocyfc	208	11	autopsy	autopsy	NN
cord-290566-tmsocyfc	208	12	found	find	VBD
cord-290566-tmsocyfc	208	13	increased	increase	VBN
cord-290566-tmsocyfc	208	14	transcripts	transcript	NNS
cord-290566-tmsocyfc	208	15	of	of	IN
cord-290566-tmsocyfc	208	16	genes	gene	NNS
cord-290566-tmsocyfc	208	17	encoding	encode	VBG
cord-290566-tmsocyfc	208	18	for	for	IN
cord-290566-tmsocyfc	208	19	IL-6	IL-6	NNP
cord-290566-tmsocyfc	208	20	,	,	,
cord-290566-tmsocyfc	208	21	IL-17	IL-17	NNP
cord-290566-tmsocyfc	208	22	,	,	,
cord-290566-tmsocyfc	208	23	and	and	CC
cord-290566-tmsocyfc	208	24	IFN-	IFN-	NNP
cord-290566-tmsocyfc	208	25	(	(	-LRB-
cord-290566-tmsocyfc	208	26	Lock	Lock	NNP
cord-290566-tmsocyfc	208	27	et	et	FW
cord-290566-tmsocyfc	208	28	al	al	NNP
cord-290566-tmsocyfc	208	29	.	.	NNP
cord-290566-tmsocyfc	208	30	,	,	,
cord-290566-tmsocyfc	208	31	2002	2002	CD
cord-290566-tmsocyfc	208	32	)	)	-RRB-
cord-290566-tmsocyfc	208	33	,	,	,
cord-290566-tmsocyfc	208	34	indicating	indicate	VBG
cord-290566-tmsocyfc	208	35	a	a	DT
cord-290566-tmsocyfc	208	36	potential	potential	JJ
cord-290566-tmsocyfc	208	37	role	role	NN
cord-290566-tmsocyfc	208	38	for	for	IN
cord-290566-tmsocyfc	208	39	both	both	CC
cord-290566-tmsocyfc	208	40	Th1	th1	CD
cord-290566-tmsocyfc	208	41	and	and	CC
cord-290566-tmsocyfc	208	42	Th17	Th17	NNP
cord-290566-tmsocyfc	208	43	cells	cell	NNS
cord-290566-tmsocyfc	208	44	in	in	IN
cord-290566-tmsocyfc	208	45	proinflammatory	proinflammatory	JJ
cord-290566-tmsocyfc	208	46	responses	response	NNS
cord-290566-tmsocyfc	208	47	in	in	IN
cord-290566-tmsocyfc	208	48	MS	MS	NNP
cord-290566-tmsocyfc	208	49	.	.	.
cord-290566-tmsocyfc	209	1	Several	several	JJ
cord-290566-tmsocyfc	209	2	studies	study	NNS
cord-290566-tmsocyfc	209	3	have	have	VBP
cord-290566-tmsocyfc	209	4	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	209	5	enhanced	enhanced	JJ
cord-290566-tmsocyfc	209	6	production	production	NN
cord-290566-tmsocyfc	209	7	of	of	IN
cord-290566-tmsocyfc	209	8	the	the	DT
cord-290566-tmsocyfc	209	9	hallmark	hallmark	JJ
cord-290566-tmsocyfc	209	10	Th1	th1	CD
cord-290566-tmsocyfc	209	11	cytokine	cytokine	NN
cord-290566-tmsocyfc	209	12	,	,	,
cord-290566-tmsocyfc	209	13	IFN-	IFN-	NNP
cord-290566-tmsocyfc	209	14	,	,	,
cord-290566-tmsocyfc	209	15	from	from	IN
cord-290566-tmsocyfc	209	16	PBMCs	PBMCs	NNP
cord-290566-tmsocyfc	209	17	restimulated	restimulate	VBD
cord-290566-tmsocyfc	209	18	ex	ex	FW
cord-290566-tmsocyfc	209	19	vivo	vivo	NN
cord-290566-tmsocyfc	209	20	in	in	IN
cord-290566-tmsocyfc	209	21	MS	MS	NNP
cord-290566-tmsocyfc	209	22	patients	patient	NNS
cord-290566-tmsocyfc	209	23	compared	compare	VBN
cord-290566-tmsocyfc	209	24	to	to	IN
cord-290566-tmsocyfc	209	25	controls	control	VBZ
cord-290566-tmsocyfc	209	26	Comabella	Comabella	NNP
cord-290566-tmsocyfc	209	27	et	et	NNP
cord-290566-tmsocyfc	209	28	al	al	NNP
cord-290566-tmsocyfc	209	29	.	.	NNP
cord-290566-tmsocyfc	209	30	,	,	,
cord-290566-tmsocyfc	209	31	1998	1998	CD
cord-290566-tmsocyfc	209	32	)	)	-RRB-
cord-290566-tmsocyfc	209	33	.	.	.
cord-290566-tmsocyfc	210	1	Clinical	clinical	JJ
cord-290566-tmsocyfc	210	2	attacks	attack	NNS
cord-290566-tmsocyfc	210	3	correlated	correlate	VBD
cord-290566-tmsocyfc	210	4	with	with	IN
cord-290566-tmsocyfc	210	5	increased	increase	VBN
cord-290566-tmsocyfc	210	6	IFN	IFN	NNP
cord-290566-tmsocyfc	210	7	-	-	HYPH
cord-290566-tmsocyfc	210	8	production	production	NN
cord-290566-tmsocyfc	210	9	in	in	IN
cord-290566-tmsocyfc	210	10	vitro	vitro	FW
cord-290566-tmsocyfc	210	11	(	(	-LRB-
cord-290566-tmsocyfc	210	12	Beck	Beck	NNP
cord-290566-tmsocyfc	210	13	et	et	NNP
cord-290566-tmsocyfc	210	14	al	al	NNP
cord-290566-tmsocyfc	210	15	.	.	NNP
cord-290566-tmsocyfc	210	16	,	,	,
cord-290566-tmsocyfc	210	17	1988	1988	CD
cord-290566-tmsocyfc	210	18	)	)	-RRB-
cord-290566-tmsocyfc	210	19	.	.	.
cord-290566-tmsocyfc	211	1	In	in	IN
cord-290566-tmsocyfc	211	2	a	a	DT
cord-290566-tmsocyfc	211	3	similar	similar	JJ
cord-290566-tmsocyfc	211	4	study	study	NN
cord-290566-tmsocyfc	211	5	,	,	,
cord-290566-tmsocyfc	211	6	IFNwas	IFNwas	NNP
cord-290566-tmsocyfc	211	7	found	find	VBD
cord-290566-tmsocyfc	211	8	to	to	TO
cord-290566-tmsocyfc	211	9	blunt	blunt	VB
cord-290566-tmsocyfc	211	10	increased	increased	JJ
cord-290566-tmsocyfc	211	11	production	production	NN
cord-290566-tmsocyfc	211	12	of	of	IN
cord-290566-tmsocyfc	211	13	IFN	IFN	NNP
cord-290566-tmsocyfc	211	14	-	-	:
cord-290566-tmsocyfc	211	15	during	during	IN
cord-290566-tmsocyfc	211	16	relapse	relapse	NN
cord-290566-tmsocyfc	212	1	(	(	-LRB-
cord-290566-tmsocyfc	212	2	Becher	Becher	NNP
cord-290566-tmsocyfc	212	3	et	et	NNP
cord-290566-tmsocyfc	212	4	al	al	NNP
cord-290566-tmsocyfc	212	5	.	.	NNP
cord-290566-tmsocyfc	212	6	,	,	,
cord-290566-tmsocyfc	212	7	1999	1999	CD
cord-290566-tmsocyfc	212	8	)	)	-RRB-
cord-290566-tmsocyfc	212	9	.	.	.
cord-290566-tmsocyfc	213	1	TCR	TCR	NNP
cord-290566-tmsocyfc	213	2	-	-	HYPH
cord-290566-tmsocyfc	213	3	mediated	mediate	VBN
cord-290566-tmsocyfc	213	4	IFN	IFN	NNP
cord-290566-tmsocyfc	213	5	-	-	:
cord-290566-tmsocyfc	213	6	and	and	CC
cord-290566-tmsocyfc	213	7	IL-10	IL-10	NNP
cord-290566-tmsocyfc	213	8	secretions	secretion	NNS
cord-290566-tmsocyfc	213	9	are	be	VBP
cord-290566-tmsocyfc	213	10	increased	increase	VBN
cord-290566-tmsocyfc	213	11	in	in	IN
cord-290566-tmsocyfc	213	12	relapsingremitting	relapsingremitting	NN
cord-290566-tmsocyfc	213	13	(	(	-LRB-
cord-290566-tmsocyfc	213	14	RR	RR	NNP
cord-290566-tmsocyfc	213	15	)	)	-RRB-
cord-290566-tmsocyfc	213	16	and	and	CC
cord-290566-tmsocyfc	213	17	secondary	secondary	JJ
cord-290566-tmsocyfc	213	18	progressive	progressive	JJ
cord-290566-tmsocyfc	213	19	(	(	-LRB-
cord-290566-tmsocyfc	213	20	SP	SP	NNP
cord-290566-tmsocyfc	213	21	)	)	-RRB-
cord-290566-tmsocyfc	213	22	patients	patient	NNS
cord-290566-tmsocyfc	213	23	,	,	,
cord-290566-tmsocyfc	213	24	but	but	CC
cord-290566-tmsocyfc	213	25	not	not	RB
cord-290566-tmsocyfc	213	26	in	in	IN
cord-290566-tmsocyfc	213	27	primary	primary	JJ
cord-290566-tmsocyfc	213	28	progressive	progressive	JJ
cord-290566-tmsocyfc	213	29	disease	disease	NN
cord-290566-tmsocyfc	213	30	,	,	,
cord-290566-tmsocyfc	213	31	suggesting	suggest	VBG
cord-290566-tmsocyfc	213	32	a	a	DT
cord-290566-tmsocyfc	213	33	dysregulation	dysregulation	NN
cord-290566-tmsocyfc	213	34	of	of	IN
cord-290566-tmsocyfc	213	35	this	this	DT
cord-290566-tmsocyfc	213	36	signaling	signal	VBG
cord-290566-tmsocyfc	213	37	pathway	pathway	NN
cord-290566-tmsocyfc	213	38	in	in	IN
cord-290566-tmsocyfc	213	39	certain	certain	JJ
cord-290566-tmsocyfc	213	40	MS	MS	NNP
cord-290566-tmsocyfc	213	41	subtypes	subtype	NNS
cord-290566-tmsocyfc	213	42	(	(	-LRB-
cord-290566-tmsocyfc	213	43	Balashov	Balashov	NNP
cord-290566-tmsocyfc	213	44	et	et	NNP
cord-290566-tmsocyfc	213	45	al	al	NNP
cord-290566-tmsocyfc	213	46	.	.	NNP
cord-290566-tmsocyfc	213	47	,	,	,
cord-290566-tmsocyfc	213	48	2000	2000	CD
cord-290566-tmsocyfc	213	49	)	)	-RRB-
cord-290566-tmsocyfc	213	50	.	.	.
cord-290566-tmsocyfc	214	1	Interestingly	interestingly	RB
cord-290566-tmsocyfc	214	2	,	,	,
cord-290566-tmsocyfc	214	3	SPMS	SPMS	NNP
cord-290566-tmsocyfc	214	4	patients	patient	NNS
cord-290566-tmsocyfc	214	5	also	also	RB
cord-290566-tmsocyfc	214	6	exhibit	exhibit	VBP
cord-290566-tmsocyfc	214	7	seasonal	seasonal	JJ
cord-290566-tmsocyfc	214	8	variations	variation	NNS
cord-290566-tmsocyfc	214	9	of	of	IN
cord-290566-tmsocyfc	214	10	IFN	IFN	NNP
cord-290566-tmsocyfc	214	11	-	-	HYPH
cord-290566-tmsocyfc	214	12	production	production	NN
cord-290566-tmsocyfc	214	13	with	with	IN
cord-290566-tmsocyfc	214	14	increased	increase	VBN
cord-290566-tmsocyfc	214	15	expression	expression	NN
cord-290566-tmsocyfc	214	16	in	in	IN
cord-290566-tmsocyfc	214	17	autumn	autumn	NN
cord-290566-tmsocyfc	214	18	and	and	CC
cord-290566-tmsocyfc	214	19	winter	winter	NN
cord-290566-tmsocyfc	214	20	months	month	NNS
cord-290566-tmsocyfc	214	21	compared	compare	VBN
cord-290566-tmsocyfc	214	22	with	with	IN
cord-290566-tmsocyfc	214	23	spring	spring	NN
cord-290566-tmsocyfc	214	24	and	and	CC
cord-290566-tmsocyfc	214	25	summer	summer	NN
cord-290566-tmsocyfc	214	26	months	month	NNS
cord-290566-tmsocyfc	214	27	,	,	,
cord-290566-tmsocyfc	214	28	which	which	WDT
cord-290566-tmsocyfc	214	29	was	be	VBD
cord-290566-tmsocyfc	214	30	not	not	RB
cord-290566-tmsocyfc	214	31	observed	observe	VBN
cord-290566-tmsocyfc	214	32	in	in	IN
cord-290566-tmsocyfc	214	33	normal	normal	JJ
cord-290566-tmsocyfc	214	34	controls	control	NNS
cord-290566-tmsocyfc	214	35	.	.	.
cord-290566-tmsocyfc	215	1	A	a	DT
cord-290566-tmsocyfc	215	2	progressive	progressive	JJ
cord-290566-tmsocyfc	215	3	course	course	NN
cord-290566-tmsocyfc	215	4	of	of	IN
cord-290566-tmsocyfc	215	5	MS	MS	NNP
cord-290566-tmsocyfc	215	6	was	be	VBD
cord-290566-tmsocyfc	215	7	found	find	VBN
cord-290566-tmsocyfc	215	8	to	to	TO
cord-290566-tmsocyfc	215	9	be	be	VB
cord-290566-tmsocyfc	215	10	significantly	significantly	RB
cord-290566-tmsocyfc	215	11	more	more	RBR
cord-290566-tmsocyfc	215	12	frequent	frequent	JJ
cord-290566-tmsocyfc	215	13	in	in	IN
cord-290566-tmsocyfc	215	14	carriers	carrier	NNS
cord-290566-tmsocyfc	215	15	of	of	IN
cord-290566-tmsocyfc	215	16	the	the	DT
cord-290566-tmsocyfc	215	17	IFN	IFN	NNP
cord-290566-tmsocyfc	215	18	-	-	HYPH
cord-290566-tmsocyfc	215	19	receptor-2	receptor-2	NNP
cord-290566-tmsocyfc	215	20	allele	allele	NN
cord-290566-tmsocyfc	215	21	Arg64	Arg64	NNP
cord-290566-tmsocyfc	216	1	(	(	-LRB-
cord-290566-tmsocyfc	216	2	Schrijver	Schrijver	NNP
cord-290566-tmsocyfc	216	3	et	et	NNP
cord-290566-tmsocyfc	216	4	al	al	NNP
cord-290566-tmsocyfc	216	5	.	.	NNP
cord-290566-tmsocyfc	216	6	,	,	,
cord-290566-tmsocyfc	216	7	2004	2004	CD
cord-290566-tmsocyfc	216	8	)	)	-RRB-
cord-290566-tmsocyfc	216	9	.	.	.
cord-290566-tmsocyfc	217	1	Administration	administration	NN
cord-290566-tmsocyfc	217	2	of	of	IN
cord-290566-tmsocyfc	217	3	IFN	IFN	NNP
cord-290566-tmsocyfc	217	4	-	-	HYPH
cord-290566-tmsocyfc	217	5	to	to	IN
cord-290566-tmsocyfc	217	6	MS	MS	NNP
cord-290566-tmsocyfc	217	7	patients	patient	NNS
cord-290566-tmsocyfc	217	8	precipitated	precipitate	VBD
cord-290566-tmsocyfc	217	9	clinical	clinical	JJ
cord-290566-tmsocyfc	217	10	attacks	attack	NNS
cord-290566-tmsocyfc	217	11	,	,	,
cord-290566-tmsocyfc	217	12	confirming	confirm	VBG
cord-290566-tmsocyfc	217	13	the	the	DT
cord-290566-tmsocyfc	217	14	role	role	NN
cord-290566-tmsocyfc	217	15	of	of	IN
cord-290566-tmsocyfc	217	16	IFN	IFN	NNP
cord-290566-tmsocyfc	217	17	-	-	:
cord-290566-tmsocyfc	217	18	as	as	IN
cord-290566-tmsocyfc	217	19	a	a	DT
cord-290566-tmsocyfc	217	20	proinflammatory	proinflammatory	JJ
cord-290566-tmsocyfc	217	21	cytokine	cytokine	NN
cord-290566-tmsocyfc	217	22	in	in	IN
cord-290566-tmsocyfc	217	23	MS	MS	NNP
cord-290566-tmsocyfc	218	1	(	(	-LRB-
cord-290566-tmsocyfc	218	2	Panitch	Panitch	NNP
cord-290566-tmsocyfc	218	3	et	et	FW
cord-290566-tmsocyfc	218	4	al	al	NNP
cord-290566-tmsocyfc	218	5	.	.	NNP
cord-290566-tmsocyfc	218	6	,	,	,
cord-290566-tmsocyfc	218	7	1987a	1987a	CD
cord-290566-tmsocyfc	218	8	,	,	,
cord-290566-tmsocyfc	218	9	b	b	LS
cord-290566-tmsocyfc	218	10	)	)	-RRB-
cord-290566-tmsocyfc	218	11	.	.	.
cord-290566-tmsocyfc	219	1	Studies	study	NNS
cord-290566-tmsocyfc	219	2	of	of	IN
cord-290566-tmsocyfc	219	3	the	the	DT
cord-290566-tmsocyfc	219	4	prototypic	prototypic	NNP
cord-290566-tmsocyfc	219	5	Th2	Th2	NNP
cord-290566-tmsocyfc	219	6	cytokine	cytokine	NN
cord-290566-tmsocyfc	219	7	IL-4	IL-4	NNP
cord-290566-tmsocyfc	219	8	in	in	IN
cord-290566-tmsocyfc	219	9	MS	MS	NNP
cord-290566-tmsocyfc	219	10	are	be	VBP
cord-290566-tmsocyfc	219	11	limited	limit	VBN
cord-290566-tmsocyfc	219	12	,	,	,
cord-290566-tmsocyfc	219	13	IL-4	IL-4	NNP
cord-290566-tmsocyfc	219	14	was	be	VBD
cord-290566-tmsocyfc	219	15	expressed	express	VBN
cord-290566-tmsocyfc	219	16	in	in	IN
cord-290566-tmsocyfc	219	17	high	high	JJ
cord-290566-tmsocyfc	219	18	levels	level	NNS
cord-290566-tmsocyfc	219	19	in	in	IN
cord-290566-tmsocyfc	219	20	both	both	DT
cord-290566-tmsocyfc	219	21	acute	acute	JJ
cord-290566-tmsocyfc	219	22	-	-	HYPH
cord-290566-tmsocyfc	219	23	and	and	CC
cord-290566-tmsocyfc	219	24	chronic	chronic	NN
cord-290566-tmsocyfc	219	25	-	-	HYPH
cord-290566-tmsocyfc	219	26	active	active	JJ
cord-290566-tmsocyfc	219	27	MS	MS	NNP
cord-290566-tmsocyfc	219	28	lesions	lesion	NNS
cord-290566-tmsocyfc	219	29	(	(	-LRB-
cord-290566-tmsocyfc	219	30	Cannella	Cannella	NNP
cord-290566-tmsocyfc	219	31	and	and	CC
cord-290566-tmsocyfc	219	32	Raine	Raine	NNP
cord-290566-tmsocyfc	219	33	,	,	,
cord-290566-tmsocyfc	219	34	1995a	1995a	CD
cord-290566-tmsocyfc	219	35	)	)	-RRB-
cord-290566-tmsocyfc	219	36	.	.	.
cord-290566-tmsocyfc	220	1	High	high	JJ
cord-290566-tmsocyfc	220	2	frequencies	frequency	NNS
cord-290566-tmsocyfc	220	3	of	of	IN
cord-290566-tmsocyfc	220	4	T	t	NN
cord-290566-tmsocyfc	220	5	-	-	HYPH
cord-290566-tmsocyfc	220	6	cell	cell	NN
cord-290566-tmsocyfc	220	7	clones	clone	NNS
cord-290566-tmsocyfc	220	8	reactive	reactive	JJ
cord-290566-tmsocyfc	220	9	to	to	IN
cord-290566-tmsocyfc	220	10	MBP	MBP	NNP
cord-290566-tmsocyfc	220	11	-	-	:
cord-290566-tmsocyfc	220	12	and	and	CC
cord-290566-tmsocyfc	220	13	PLPexpressing	PLPexpressing	NNP
cord-290566-tmsocyfc	220	14	IL-4	IL-4	NNP
cord-290566-tmsocyfc	220	15	were	be	VBD
cord-290566-tmsocyfc	220	16	found	find	VBN
cord-290566-tmsocyfc	220	17	in	in	IN
cord-290566-tmsocyfc	220	18	MS	MS	NNP
cord-290566-tmsocyfc	220	19	patients	patient	NNS
cord-290566-tmsocyfc	220	20	compared	compare	VBN
cord-290566-tmsocyfc	220	21	with	with	IN
cord-290566-tmsocyfc	220	22	untreated	untreated	JJ
cord-290566-tmsocyfc	220	23	patients	patient	NNS
cord-290566-tmsocyfc	220	24	(	(	-LRB-
cord-290566-tmsocyfc	220	25	Chou	Chou	NNP
cord-290566-tmsocyfc	220	26	et	et	NNP
cord-290566-tmsocyfc	220	27	al	al	NNP
cord-290566-tmsocyfc	220	28	.	.	NNP
cord-290566-tmsocyfc	220	29	,	,	,
cord-290566-tmsocyfc	220	30	1992	1992	CD
cord-290566-tmsocyfc	220	31	)	)	-RRB-
cord-290566-tmsocyfc	220	32	.	.	.
cord-290566-tmsocyfc	221	1	Increased	increase	VBN
cord-290566-tmsocyfc	221	2	expression	expression	NN
cord-290566-tmsocyfc	221	3	of	of	IN
cord-290566-tmsocyfc	221	4	IL-4	IL-4	NNP
cord-290566-tmsocyfc	221	5	secretion	secretion	NN
cord-290566-tmsocyfc	221	6	by	by	IN
cord-290566-tmsocyfc	221	7	CD3-stimulated	cd3-stimulated	JJ
cord-290566-tmsocyfc	221	8	PBMCs	pbmc	NNS
cord-290566-tmsocyfc	221	9	was	be	VBD
cord-290566-tmsocyfc	221	10	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	221	11	in	in	IN
cord-290566-tmsocyfc	221	12	SPMS	SPMS	NNP
cord-290566-tmsocyfc	221	13	patients	patient	NNS
cord-290566-tmsocyfc	221	14	treated	treat	VBN
cord-290566-tmsocyfc	221	15	with	with	IN
cord-290566-tmsocyfc	221	16	cyclophosphamide/	cyclophosphamide/	CD
cord-290566-tmsocyfc	221	17	methylprednisolone	methylprednisolone	NN
cord-290566-tmsocyfc	221	18	compared	compare	VBN
cord-290566-tmsocyfc	221	19	with	with	IN
cord-290566-tmsocyfc	221	20	untreated	untreated	JJ
cord-290566-tmsocyfc	221	21	patients	patient	NNS
cord-290566-tmsocyfc	221	22	.	.	.
cord-290566-tmsocyfc	222	1	Thus	thus	RB
cord-290566-tmsocyfc	222	2	,	,	,
cord-290566-tmsocyfc	222	3	the	the	DT
cord-290566-tmsocyfc	222	4	role	role	NN
cord-290566-tmsocyfc	222	5	of	of	IN
cord-290566-tmsocyfc	222	6	IL-4	IL-4	NNP
cord-290566-tmsocyfc	222	7	in	in	IN
cord-290566-tmsocyfc	222	8	the	the	DT
cord-290566-tmsocyfc	222	9	pathogenesis	pathogenesis	NN
cord-290566-tmsocyfc	222	10	of	of	IN
cord-290566-tmsocyfc	222	11	MS	MS	NNP
cord-290566-tmsocyfc	222	12	is	be	VBZ
cord-290566-tmsocyfc	222	13	unclear	unclear	JJ
cord-290566-tmsocyfc	222	14	,	,	,
cord-290566-tmsocyfc	222	15	however	however	RB
cord-290566-tmsocyfc	222	16	may	may	MD
cord-290566-tmsocyfc	222	17	be	be	VB
cord-290566-tmsocyfc	222	18	associated	associate	VBN
cord-290566-tmsocyfc	222	19	with	with	IN
cord-290566-tmsocyfc	222	20	responses	response	NNS
cord-290566-tmsocyfc	222	21	to	to	IN
cord-290566-tmsocyfc	222	22	therapy	therapy	NN
cord-290566-tmsocyfc	222	23	.	.	.
cord-290566-tmsocyfc	223	1	Studies	study	NNS
cord-290566-tmsocyfc	223	2	examining	examine	VBG
cord-290566-tmsocyfc	223	3	Th17	th17	CD
cord-290566-tmsocyfc	223	4	cell	cell	NN
cord-290566-tmsocyfc	223	5	activity	activity	NN
cord-290566-tmsocyfc	223	6	in	in	IN
cord-290566-tmsocyfc	223	7	MS	MS	NNP
cord-290566-tmsocyfc	223	8	found	find	VBD
cord-290566-tmsocyfc	223	9	that	that	IN
cord-290566-tmsocyfc	223	10	dendritic	dendritic	JJ
cord-290566-tmsocyfc	223	11	cells	cell	NNS
cord-290566-tmsocyfc	223	12	from	from	IN
cord-290566-tmsocyfc	223	13	MS	MS	NNP
cord-290566-tmsocyfc	223	14	patients	patient	NNS
cord-290566-tmsocyfc	223	15	secrete	secrete	VBP
cord-290566-tmsocyfc	223	16	elevated	elevated	JJ
cord-290566-tmsocyfc	223	17	amounts	amount	NNS
cord-290566-tmsocyfc	223	18	of	of	IN
cord-290566-tmsocyfc	223	19	IL-23	IL-23	NNP
cord-290566-tmsocyfc	223	20	and	and	CC
cord-290566-tmsocyfc	223	21	express	express	VB
cord-290566-tmsocyfc	223	22	increased	increased	JJ
cord-290566-tmsocyfc	223	23	levels	level	NNS
cord-290566-tmsocyfc	223	24	of	of	IN
cord-290566-tmsocyfc	223	25	IL-23p19	IL-23p19	NNP
cord-290566-tmsocyfc	223	26	mRNA	mrna	NN
cord-290566-tmsocyfc	223	27	,	,	,
cord-290566-tmsocyfc	223	28	and	and	CC
cord-290566-tmsocyfc	223	29	are	be	VBP
cord-290566-tmsocyfc	223	30	associated	associate	VBN
cord-290566-tmsocyfc	223	31	with	with	IN
cord-290566-tmsocyfc	223	32	increased	increase	VBN
cord-290566-tmsocyfc	223	33	T	t	NN
cord-290566-tmsocyfc	223	34	-	-	HYPH
cord-290566-tmsocyfc	223	35	cell	cell	NN
cord-290566-tmsocyfc	223	36	production	production	NN
cord-290566-tmsocyfc	223	37	of	of	IN
cord-290566-tmsocyfc	223	38	IL-17	IL-17	NNP
cord-290566-tmsocyfc	223	39	(	(	-LRB-
cord-290566-tmsocyfc	223	40	Vaknin	Vaknin	NNP
cord-290566-tmsocyfc	223	41	-	-	HYPH
cord-290566-tmsocyfc	223	42	Dembinsky	Dembinsky	NNP
cord-290566-tmsocyfc	223	43	et	et	FW
cord-290566-tmsocyfc	223	44	al	al	NNP
cord-290566-tmsocyfc	223	45	.	.	NNP
cord-290566-tmsocyfc	223	46	,	,	,
cord-290566-tmsocyfc	223	47	2006	2006	CD
cord-290566-tmsocyfc	223	48	)	)	-RRB-
cord-290566-tmsocyfc	223	49	.	.	.
cord-290566-tmsocyfc	224	1	A	a	DT
cord-290566-tmsocyfc	224	2	Japanese	japanese	JJ
cord-290566-tmsocyfc	224	3	study	study	NN
cord-290566-tmsocyfc	224	4	examining	examine	VBG
cord-290566-tmsocyfc	224	5	cytokine	cytokine	JJ
cord-290566-tmsocyfc	224	6	expression	expression	NN
cord-290566-tmsocyfc	224	7	found	find	VBD
cord-290566-tmsocyfc	224	8	that	that	IN
cord-290566-tmsocyfc	224	9	CSF	CSF	NNP
cord-290566-tmsocyfc	224	10	levels	level	NNS
cord-290566-tmsocyfc	224	11	of	of	IN
cord-290566-tmsocyfc	224	12	IL-17	IL-17	NNP
cord-290566-tmsocyfc	224	13	,	,	,
cord-290566-tmsocyfc	224	14	IL-8	IL-8	NNP
cord-290566-tmsocyfc	224	15	,	,	,
cord-290566-tmsocyfc	224	16	and	and	CC
cord-290566-tmsocyfc	224	17	IL-5	IL-5	NNP
cord-290566-tmsocyfc	224	18	were	be	VBD
cord-290566-tmsocyfc	224	19	significantly	significantly	RB
cord-290566-tmsocyfc	224	20	higher	high	JJR
cord-290566-tmsocyfc	224	21	in	in	IN
cord-290566-tmsocyfc	224	22	opticospinal	opticospinal	JJ
cord-290566-tmsocyfc	224	23	-	-	HYPH
cord-290566-tmsocyfc	224	24	MS	MS	NNP
cord-290566-tmsocyfc	224	25	patients	patient	NNS
cord-290566-tmsocyfc	224	26	than	than	IN
cord-290566-tmsocyfc	224	27	in	in	IN
cord-290566-tmsocyfc	224	28	conventional	conventional	JJ
cord-290566-tmsocyfc	224	29	RRMS	RRMS	NNP
cord-290566-tmsocyfc	224	30	patients	patient	NNS
cord-290566-tmsocyfc	224	31	,	,	,
cord-290566-tmsocyfc	224	32	and	and	CC
cord-290566-tmsocyfc	224	33	may	may	MD
cord-290566-tmsocyfc	224	34	be	be	VB
cord-290566-tmsocyfc	224	35	associated	associate	VBN
cord-290566-tmsocyfc	224	36	with	with	IN
cord-290566-tmsocyfc	224	37	pronounced	pronounced	JJ
cord-290566-tmsocyfc	224	38	neutrophilic	neutrophilic	NN
cord-290566-tmsocyfc	224	39	infiltrates	infiltrate	VBZ
cord-290566-tmsocyfc	224	40	typically	typically	RB
cord-290566-tmsocyfc	224	41	found	find	VBN
cord-290566-tmsocyfc	224	42	in	in	IN
cord-290566-tmsocyfc	224	43	the	the	DT
cord-290566-tmsocyfc	224	44	opticospinal	opticospinal	JJ
cord-290566-tmsocyfc	224	45	disease	disease	NN
cord-290566-tmsocyfc	224	46	variant	variant	NN
cord-290566-tmsocyfc	224	47	(	(	-LRB-
cord-290566-tmsocyfc	224	48	Ishizu	Ishizu	NNP
cord-290566-tmsocyfc	224	49	et	et	NNP
cord-290566-tmsocyfc	224	50	al	al	NNP
cord-290566-tmsocyfc	224	51	.	.	NNP
cord-290566-tmsocyfc	224	52	,	,	,
cord-290566-tmsocyfc	224	53	2005	2005	CD
cord-290566-tmsocyfc	224	54	)	)	-RRB-
cord-290566-tmsocyfc	224	55	.	.	.
cord-290566-tmsocyfc	225	1	Alterations	alteration	NNS
cord-290566-tmsocyfc	225	2	in	in	IN
cord-290566-tmsocyfc	225	3	the	the	DT
cord-290566-tmsocyfc	225	4	function	function	NN
cord-290566-tmsocyfc	225	5	of	of	IN
cord-290566-tmsocyfc	225	6	several	several	JJ
cord-290566-tmsocyfc	225	7	populations	population	NNS
cord-290566-tmsocyfc	225	8	of	of	IN
cord-290566-tmsocyfc	225	9	regulatory	regulatory	JJ
cord-290566-tmsocyfc	225	10	T	t	NN
cord-290566-tmsocyfc	225	11	cells	cell	NNS
cord-290566-tmsocyfc	225	12	have	have	VBP
cord-290566-tmsocyfc	225	13	been	be	VBN
cord-290566-tmsocyfc	225	14	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	225	15	in	in	IN
cord-290566-tmsocyfc	225	16	MS	MS	NNP
cord-290566-tmsocyfc	225	17	.	.	.
cord-290566-tmsocyfc	226	1	Induction	induction	NN
cord-290566-tmsocyfc	226	2	of	of	IN
cord-290566-tmsocyfc	226	3	regulatory	regulatory	JJ
cord-290566-tmsocyfc	226	4	antigen	antigen	NN
cord-290566-tmsocyfc	226	5	-	-	HYPH
cord-290566-tmsocyfc	226	6	specific	specific	JJ
cord-290566-tmsocyfc	226	7	Th3	th3	CD
cord-290566-tmsocyfc	226	8	cells	cell	NNS
cord-290566-tmsocyfc	226	9	through	through	IN
cord-290566-tmsocyfc	226	10	oral	oral	JJ
cord-290566-tmsocyfc	226	11	tolerance	tolerance	NN
cord-290566-tmsocyfc	226	12	with	with	IN
cord-290566-tmsocyfc	226	13	myelin	myelin	NN
cord-290566-tmsocyfc	226	14	proteins	protein	NNS
cord-290566-tmsocyfc	226	15	has	have	VBZ
cord-290566-tmsocyfc	226	16	been	be	VBN
cord-290566-tmsocyfc	226	17	described	describe	VBN
cord-290566-tmsocyfc	227	1	(	(	-LRB-
cord-290566-tmsocyfc	227	2	Fukaura	Fukaura	NNP
cord-290566-tmsocyfc	227	3	et	et	FW
cord-290566-tmsocyfc	227	4	al	al	NNP
cord-290566-tmsocyfc	227	5	.	.	.
cord-290566-tmsocyfc	228	1	,	,	,
cord-290566-tmsocyfc	228	2	1996	1996	CD
cord-290566-tmsocyfc	228	3	;	;	:
cord-290566-tmsocyfc	228	4	Hafler	Hafler	NNP
cord-290566-tmsocyfc	228	5	et	et	NNP
cord-290566-tmsocyfc	228	6	al	al	NNP
cord-290566-tmsocyfc	228	7	.	.	NNP
cord-290566-tmsocyfc	228	8	,	,	,
cord-290566-tmsocyfc	228	9	1997	1997	CD
cord-290566-tmsocyfc	228	10	)	)	-RRB-
cord-290566-tmsocyfc	228	11	.	.	.
cord-290566-tmsocyfc	229	1	Deficiency	deficiency	NN
cord-290566-tmsocyfc	229	2	in	in	IN
cord-290566-tmsocyfc	229	3	the	the	DT
cord-290566-tmsocyfc	229	4	CD8þCD28À	cd8þcd28à	RB
cord-290566-tmsocyfc	229	5	subset	subset	JJ
cord-290566-tmsocyfc	229	6	of	of	IN
cord-290566-tmsocyfc	229	7	suppressor	suppressor	NN
cord-290566-tmsocyfc	229	8	cells	cell	NNS
cord-290566-tmsocyfc	229	9	has	have	VBZ
cord-290566-tmsocyfc	229	10	been	be	VBN
cord-290566-tmsocyfc	229	11	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	229	12	in	in	IN
cord-290566-tmsocyfc	229	13	MS	MS	NNP
cord-290566-tmsocyfc	229	14	patients	patient	NNS
cord-290566-tmsocyfc	229	15	(	(	-LRB-
cord-290566-tmsocyfc	229	16	Crucian	Crucian	NNP
cord-290566-tmsocyfc	229	17	et	et	FW
cord-290566-tmsocyfc	229	18	al	al	NNP
cord-290566-tmsocyfc	229	19	.	.	NNP
cord-290566-tmsocyfc	229	20	,	,	,
cord-290566-tmsocyfc	229	21	1995	1995	CD
cord-290566-tmsocyfc	229	22	)	)	-RRB-
cord-290566-tmsocyfc	229	23	.	.	.
cord-290566-tmsocyfc	230	1	Moreover	moreover	RB
cord-290566-tmsocyfc	230	2	,	,	,
cord-290566-tmsocyfc	230	3	increases	increase	NNS
cord-290566-tmsocyfc	230	4	in	in	IN
cord-290566-tmsocyfc	230	5	-adrenergic	-adrenergic	JJ
cord-290566-tmsocyfc	230	6	receptor	receptor	NN
cord-290566-tmsocyfc	230	7	density	density	NN
cord-290566-tmsocyfc	230	8	on	on	IN
cord-290566-tmsocyfc	230	9	CD8þCD28À	cd8þcd28à	JJ
cord-290566-tmsocyfc	230	10	cells	cell	NNS
cord-290566-tmsocyfc	230	11	were	be	VBD
cord-290566-tmsocyfc	230	12	found	find	VBN
cord-290566-tmsocyfc	230	13	in	in	IN
cord-290566-tmsocyfc	230	14	MS	MS	NNP
cord-290566-tmsocyfc	230	15	compared	compare	VBN
cord-290566-tmsocyfc	230	16	with	with	IN
cord-290566-tmsocyfc	230	17	controls	control	NNS
cord-290566-tmsocyfc	230	18	(	(	-LRB-
cord-290566-tmsocyfc	230	19	Karaszewski	Karaszewski	NNP
cord-290566-tmsocyfc	230	20	et	et	NNP
cord-290566-tmsocyfc	230	21	al	al	NNP
cord-290566-tmsocyfc	230	22	.	.	NNP
cord-290566-tmsocyfc	230	23	,	,	,
cord-290566-tmsocyfc	230	24	1991	1991	CD
cord-290566-tmsocyfc	230	25	)	)	-RRB-
cord-290566-tmsocyfc	230	26	.	.	.
cord-290566-tmsocyfc	231	1	Much	much	JJ
cord-290566-tmsocyfc	231	2	attention	attention	NN
cord-290566-tmsocyfc	231	3	has	have	VBZ
cord-290566-tmsocyfc	231	4	focused	focus	VBN
cord-290566-tmsocyfc	231	5	on	on	IN
cord-290566-tmsocyfc	231	6	the	the	DT
cord-290566-tmsocyfc	231	7	CD4þCD25þ	CD4þCD25þ	NNP
cord-290566-tmsocyfc	231	8	subset	subset	VBN
cord-290566-tmsocyfc	231	9	of	of	IN
cord-290566-tmsocyfc	231	10	regulatory	regulatory	JJ
cord-290566-tmsocyfc	231	11	T	t	NN
cord-290566-tmsocyfc	231	12	cells	cell	NNS
cord-290566-tmsocyfc	231	13	.	.	.
cord-290566-tmsocyfc	232	1	Induction	Induction	NNP
cord-290566-tmsocyfc	232	2	of	of	IN
cord-290566-tmsocyfc	232	3	CD4þCD25þ	CD4þCD25þ	NNP
cord-290566-tmsocyfc	232	4	T	t	NN
cord-290566-tmsocyfc	232	5	cells	cell	NNS
cord-290566-tmsocyfc	232	6	is	be	VBZ
cord-290566-tmsocyfc	232	7	controlled	control	VBN
cord-290566-tmsocyfc	232	8	by	by	IN
cord-290566-tmsocyfc	232	9	the	the	DT
cord-290566-tmsocyfc	232	10	transcription	transcription	NN
cord-290566-tmsocyfc	232	11	regulator	regulator	NN
cord-290566-tmsocyfc	232	12	FOXP3	FOXP3	NNP
cord-290566-tmsocyfc	232	13	which	which	WDT
cord-290566-tmsocyfc	232	14	also	also	RB
cord-290566-tmsocyfc	232	15	serves	serve	VBZ
cord-290566-tmsocyfc	232	16	as	as	IN
cord-290566-tmsocyfc	232	17	a	a	DT
cord-290566-tmsocyfc	232	18	cell	cell	NN
cord-290566-tmsocyfc	232	19	-	-	HYPH
cord-290566-tmsocyfc	232	20	specific	specific	JJ
cord-290566-tmsocyfc	232	21	marker	marker	NN
cord-290566-tmsocyfc	232	22	(	(	-LRB-
cord-290566-tmsocyfc	232	23	Hori	Hori	NNP
cord-290566-tmsocyfc	232	24	et	et	NNP
cord-290566-tmsocyfc	232	25	al	al	NNP
cord-290566-tmsocyfc	232	26	.	.	NNP
cord-290566-tmsocyfc	232	27	,	,	,
cord-290566-tmsocyfc	232	28	2003	2003	CD
cord-290566-tmsocyfc	232	29	)	)	-RRB-
cord-290566-tmsocyfc	232	30	.	.	.
cord-290566-tmsocyfc	233	1	Defects	defect	NNS
cord-290566-tmsocyfc	233	2	in	in	IN
cord-290566-tmsocyfc	233	3	the	the	DT
cord-290566-tmsocyfc	233	4	eVector	eVector	NNP
cord-290566-tmsocyfc	233	5	function	function	NN
cord-290566-tmsocyfc	233	6	of	of	IN
cord-290566-tmsocyfc	233	7	CD4þCD25þ	CD4þCD25þ	NNP
cord-290566-tmsocyfc	233	8	regulatory	regulatory	JJ
cord-290566-tmsocyfc	233	9	T	T	NNP
cord-290566-tmsocyfc	233	10	cells	cell	NNS
cord-290566-tmsocyfc	233	11	have	have	VBP
cord-290566-tmsocyfc	233	12	been	be	VBN
cord-290566-tmsocyfc	233	13	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	233	14	in	in	IN
cord-290566-tmsocyfc	233	15	MS	MS	NNP
cord-290566-tmsocyfc	233	16	patients	patient	NNS
cord-290566-tmsocyfc	233	17	(	(	-LRB-
cord-290566-tmsocyfc	233	18	Viglietta	Viglietta	NNP
cord-290566-tmsocyfc	233	19	et	et	NNP
cord-290566-tmsocyfc	233	20	al	al	NNP
cord-290566-tmsocyfc	233	21	.	.	NNP
cord-290566-tmsocyfc	233	22	,	,	,
cord-290566-tmsocyfc	233	23	2004	2004	CD
cord-290566-tmsocyfc	233	24	)	)	-RRB-
cord-290566-tmsocyfc	233	25	.	.	.
cord-290566-tmsocyfc	234	1	Thus	thus	RB
cord-290566-tmsocyfc	234	2	,	,	,
cord-290566-tmsocyfc	234	3	defects	defect	NNS
cord-290566-tmsocyfc	234	4	in	in	IN
cord-290566-tmsocyfc	234	5	regulatory	regulatory	JJ
cord-290566-tmsocyfc	234	6	T	t	NN
cord-290566-tmsocyfc	234	7	-	-	HYPH
cord-290566-tmsocyfc	234	8	cell	cell	NN
cord-290566-tmsocyfc	234	9	populations	population	NNS
cord-290566-tmsocyfc	234	10	may	may	MD
cord-290566-tmsocyfc	234	11	facilitate	facilitate	VB
cord-290566-tmsocyfc	234	12	the	the	DT
cord-290566-tmsocyfc	234	13	development	development	NN
cord-290566-tmsocyfc	234	14	and/or	and/or	CC
cord-290566-tmsocyfc	234	15	progression	progression	NN
cord-290566-tmsocyfc	234	16	of	of	IN
cord-290566-tmsocyfc	234	17	autoimmunity	autoimmunity	NN
cord-290566-tmsocyfc	234	18	.	.	.
cord-290566-tmsocyfc	235	1	T	t	NN
cord-290566-tmsocyfc	235	2	-	-	HYPH
cord-290566-tmsocyfc	235	3	cell	cell	NN
cord-290566-tmsocyfc	235	4	migration	migration	NN
cord-290566-tmsocyfc	235	5	into	into	IN
cord-290566-tmsocyfc	235	6	the	the	DT
cord-290566-tmsocyfc	235	7	CNS	CNS	NNP
cord-290566-tmsocyfc	235	8	in	in	IN
cord-290566-tmsocyfc	235	9	MS	MS	NNP
cord-290566-tmsocyfc	235	10	is	be	VBZ
cord-290566-tmsocyfc	235	11	believed	believe	VBN
cord-290566-tmsocyfc	235	12	to	to	TO
cord-290566-tmsocyfc	235	13	follow	follow	VB
cord-290566-tmsocyfc	235	14	the	the	DT
cord-290566-tmsocyfc	235	15	sequence	sequence	NN
cord-290566-tmsocyfc	235	16	of	of	IN
cord-290566-tmsocyfc	235	17	capture	capture	NN
cord-290566-tmsocyfc	235	18	,	,	,
cord-290566-tmsocyfc	235	19	rolling	rolling	NN
cord-290566-tmsocyfc	235	20	,	,	,
cord-290566-tmsocyfc	235	21	activation	activation	NN
cord-290566-tmsocyfc	235	22	,	,	,
cord-290566-tmsocyfc	235	23	adhesion	adhesion	NN
cord-290566-tmsocyfc	235	24	strengthening	strengthening	NN
cord-290566-tmsocyfc	235	25	,	,	,
cord-290566-tmsocyfc	235	26	and	and	CC
cord-290566-tmsocyfc	235	27	finally	finally	RB
cord-290566-tmsocyfc	235	28	transmigration	transmigration	NN
cord-290566-tmsocyfc	235	29	through	through	IN
cord-290566-tmsocyfc	235	30	the	the	DT
cord-290566-tmsocyfc	235	31	BBB	BBB	NNP
cord-290566-tmsocyfc	235	32	.	.	.
cord-290566-tmsocyfc	236	1	The	the	DT
cord-290566-tmsocyfc	236	2	specifics	specific	NNS
cord-290566-tmsocyfc	236	3	of	of	IN
cord-290566-tmsocyfc	236	4	these	these	DT
cord-290566-tmsocyfc	236	5	events	event	NNS
cord-290566-tmsocyfc	236	6	may	may	MD
cord-290566-tmsocyfc	236	7	vary	vary	VB
cord-290566-tmsocyfc	236	8	depending	depend	VBG
cord-290566-tmsocyfc	236	9	on	on	IN
cord-290566-tmsocyfc	236	10	the	the	DT
cord-290566-tmsocyfc	236	11	region	region	NN
cord-290566-tmsocyfc	236	12	of	of	IN
cord-290566-tmsocyfc	236	13	the	the	DT
cord-290566-tmsocyfc	236	14	CNS	CNS	NNP
cord-290566-tmsocyfc	236	15	,	,	,
cord-290566-tmsocyfc	236	16	as	as	RB
cord-290566-tmsocyfc	236	17	well	well	RB
cord-290566-tmsocyfc	236	18	as	as	IN
cord-290566-tmsocyfc	236	19	the	the	DT
cord-290566-tmsocyfc	236	20	activation	activation	NN
cord-290566-tmsocyfc	236	21	state	state	NN
cord-290566-tmsocyfc	236	22	of	of	IN
cord-290566-tmsocyfc	236	23	T	T	NNP
cord-290566-tmsocyfc	236	24	cells	cell	NNS
cord-290566-tmsocyfc	236	25	and	and	CC
cord-290566-tmsocyfc	236	26	microvasculature	microvasculature	NN
cord-290566-tmsocyfc	236	27	.	.	.
cord-290566-tmsocyfc	237	1	Two	two	CD
cord-290566-tmsocyfc	237	2	processes	process	NNS
cord-290566-tmsocyfc	237	3	appear	appear	VBP
cord-290566-tmsocyfc	237	4	to	to	TO
cord-290566-tmsocyfc	237	5	be	be	VB
cord-290566-tmsocyfc	237	6	important	important	JJ
cord-290566-tmsocyfc	237	7	in	in	IN
cord-290566-tmsocyfc	237	8	T	t	NN
cord-290566-tmsocyfc	237	9	-	-	HYPH
cord-290566-tmsocyfc	237	10	cell	cell	NN
cord-290566-tmsocyfc	237	11	migration	migration	NN
cord-290566-tmsocyfc	237	12	into	into	IN
cord-290566-tmsocyfc	237	13	the	the	DT
cord-290566-tmsocyfc	237	14	CNS	CNS	NNP
cord-290566-tmsocyfc	237	15	:	:	:
cord-290566-tmsocyfc	237	16	(	(	-LRB-
cord-290566-tmsocyfc	237	17	1	1	LS
cord-290566-tmsocyfc	237	18	)	)	-RRB-
cord-290566-tmsocyfc	237	19	migration	migration	NN
cord-290566-tmsocyfc	237	20	of	of	IN
cord-290566-tmsocyfc	237	21	T	t	NN
cord-290566-tmsocyfc	237	22	cells	cell	NNS
cord-290566-tmsocyfc	237	23	from	from	IN
cord-290566-tmsocyfc	237	24	the	the	DT
cord-290566-tmsocyfc	237	25	blood	blood	NN
cord-290566-tmsocyfc	237	26	into	into	IN
cord-290566-tmsocyfc	237	27	the	the	DT
cord-290566-tmsocyfc	237	28	CSF	CSF	NNP
cord-290566-tmsocyfc	237	29	with	with	IN
cord-290566-tmsocyfc	237	30	interactions	interaction	NNS
cord-290566-tmsocyfc	237	31	with	with	IN
cord-290566-tmsocyfc	237	32	dendritic	dendritic	JJ
cord-290566-tmsocyfc	237	33	elements	element	NNS
cord-290566-tmsocyfc	237	34	on	on	IN
cord-290566-tmsocyfc	237	35	the	the	DT
cord-290566-tmsocyfc	237	36	luminal	luminal	JJ
cord-290566-tmsocyfc	237	37	surface	surface	NN
cord-290566-tmsocyfc	237	38	of	of	IN
cord-290566-tmsocyfc	237	39	the	the	DT
cord-290566-tmsocyfc	237	40	choroid	choroid	JJ
cord-290566-tmsocyfc	237	41	plexus	plexus	NN
cord-290566-tmsocyfc	237	42	resulting	result	VBG
cord-290566-tmsocyfc	237	43	in	in	IN
cord-290566-tmsocyfc	237	44	immunosurveillance	immunosurveillance	NN
cord-290566-tmsocyfc	237	45	and	and	CC
cord-290566-tmsocyfc	237	46	(	(	-LRB-
cord-290566-tmsocyfc	237	47	2	2	LS
cord-290566-tmsocyfc	237	48	)	)	-RRB-
cord-290566-tmsocyfc	237	49	T	t	NN
cord-290566-tmsocyfc	237	50	-	-	HYPH
cord-290566-tmsocyfc	237	51	cell	cell	NN
cord-290566-tmsocyfc	237	52	migration	migration	NN
cord-290566-tmsocyfc	237	53	through	through	IN
cord-290566-tmsocyfc	237	54	inflamed	inflamed	JJ
cord-290566-tmsocyfc	237	55	endothelial	endothelial	JJ
cord-290566-tmsocyfc	237	56	BBB	BBB	NNP
cord-290566-tmsocyfc	237	57	and	and	CC
cord-290566-tmsocyfc	237	58	interactions	interaction	NNS
cord-290566-tmsocyfc	237	59	with	with	IN
cord-290566-tmsocyfc	237	60	perivascular	perivascular	JJ
cord-290566-tmsocyfc	237	61	APCs	apc	NNS
cord-290566-tmsocyfc	237	62	within	within	IN
cord-290566-tmsocyfc	237	63	the	the	DT
cord-290566-tmsocyfc	237	64	Virchow	Virchow	NNP
cord-290566-tmsocyfc	237	65	-	-	HYPH
cord-290566-tmsocyfc	237	66	Robbins	Robbins	NNP
cord-290566-tmsocyfc	237	67	space	space	NN
cord-290566-tmsocyfc	237	68	(	(	-LRB-
cord-290566-tmsocyfc	237	69	Engelhardt	Engelhardt	NNP
cord-290566-tmsocyfc	237	70	and	and	CC
cord-290566-tmsocyfc	237	71	RansohoV	RansohoV	NNP
cord-290566-tmsocyfc	237	72	,	,	,
cord-290566-tmsocyfc	237	73	2005	2005	CD
cord-290566-tmsocyfc	237	74	)	)	-RRB-
cord-290566-tmsocyfc	237	75	.	.	.
cord-290566-tmsocyfc	238	1	Evidence	evidence	NN
cord-290566-tmsocyfc	238	2	exists	exist	VBZ
cord-290566-tmsocyfc	238	3	for	for	IN
cord-290566-tmsocyfc	238	4	both	both	DT
cord-290566-tmsocyfc	238	5	of	of	IN
cord-290566-tmsocyfc	238	6	these	these	DT
cord-290566-tmsocyfc	238	7	processes	process	NNS
cord-290566-tmsocyfc	238	8	in	in	IN
cord-290566-tmsocyfc	238	9	MS	MS	NNP
cord-290566-tmsocyfc	238	10	,	,	,
cord-290566-tmsocyfc	238	11	however	however	RB
cord-290566-tmsocyfc	238	12	the	the	DT
cord-290566-tmsocyfc	238	13	relative	relative	JJ
cord-290566-tmsocyfc	238	14	contribution	contribution	NN
cord-290566-tmsocyfc	238	15	of	of	IN
cord-290566-tmsocyfc	238	16	each	each	DT
cord-290566-tmsocyfc	238	17	is	be	VBZ
cord-290566-tmsocyfc	238	18	unclear	unclear	JJ
cord-290566-tmsocyfc	238	19	,	,	,
cord-290566-tmsocyfc	238	20	and	and	CC
cord-290566-tmsocyfc	238	21	may	may	MD
cord-290566-tmsocyfc	238	22	depend	depend	VB
cord-290566-tmsocyfc	238	23	on	on	IN
cord-290566-tmsocyfc	238	24	the	the	DT
cord-290566-tmsocyfc	238	25	stage	stage	NN
cord-290566-tmsocyfc	238	26	and	and	CC
cord-290566-tmsocyfc	238	27	subtype	subtype	NN
cord-290566-tmsocyfc	238	28	of	of	IN
cord-290566-tmsocyfc	238	29	disease	disease	NN
cord-290566-tmsocyfc	238	30	.	.	.
cord-290566-tmsocyfc	239	1	Adhesion	adhesion	NN
cord-290566-tmsocyfc	239	2	molecule	molecule	NN
cord-290566-tmsocyfc	239	3	ICAM-1	ICAM-1	NNP
cord-290566-tmsocyfc	239	4	is	be	VBZ
cord-290566-tmsocyfc	239	5	expressed	express	VBN
cord-290566-tmsocyfc	239	6	on	on	IN
cord-290566-tmsocyfc	239	7	the	the	DT
cord-290566-tmsocyfc	239	8	inflamed	inflamed	JJ
cord-290566-tmsocyfc	239	9	BBB	BBB	NNP
cord-290566-tmsocyfc	239	10	in	in	IN
cord-290566-tmsocyfc	239	11	MS	MS	NNP
cord-290566-tmsocyfc	239	12	,	,	,
cord-290566-tmsocyfc	239	13	while	while	IN
cord-290566-tmsocyfc	239	14	LFA-1	LFA-1	NNP
cord-290566-tmsocyfc	239	15	is	be	VBZ
cord-290566-tmsocyfc	239	16	expressed	express	VBN
cord-290566-tmsocyfc	239	17	on	on	IN
cord-290566-tmsocyfc	239	18	infiltrating	infiltrate	VBG
cord-290566-tmsocyfc	239	19	T	t	NN
cord-290566-tmsocyfc	239	20	cells	cell	NNS
cord-290566-tmsocyfc	239	21	,	,	,
cord-290566-tmsocyfc	239	22	suggesting	suggest	VBG
cord-290566-tmsocyfc	239	23	an	an	DT
cord-290566-tmsocyfc	239	24	important	important	JJ
cord-290566-tmsocyfc	239	25	role	role	NN
cord-290566-tmsocyfc	239	26	for	for	IN
cord-290566-tmsocyfc	239	27	this	this	DT
cord-290566-tmsocyfc	239	28	pathway	pathway	NN
cord-290566-tmsocyfc	239	29	in	in	IN
cord-290566-tmsocyfc	239	30	T	t	NN
cord-290566-tmsocyfc	239	31	-	-	HYPH
cord-290566-tmsocyfc	239	32	cell	cell	NN
cord-290566-tmsocyfc	239	33	migration	migration	NN
cord-290566-tmsocyfc	239	34	in	in	IN
cord-290566-tmsocyfc	239	35	MS	MS	NNP
cord-290566-tmsocyfc	239	36	(	(	-LRB-
cord-290566-tmsocyfc	239	37	Bo	Bo	NNP
cord-290566-tmsocyfc	239	38	et	et	FW
cord-290566-tmsocyfc	239	39	al	al	NNP
cord-290566-tmsocyfc	239	40	.	.	NNP
cord-290566-tmsocyfc	239	41	,	,	,
cord-290566-tmsocyfc	239	42	1996	1996	CD
cord-290566-tmsocyfc	239	43	)	)	-RRB-
cord-290566-tmsocyfc	239	44	.	.	.
cord-290566-tmsocyfc	240	1	Inhibition	inhibition	NN
cord-290566-tmsocyfc	240	2	of	of	IN
cord-290566-tmsocyfc	240	3	interactions	interaction	NNS
cord-290566-tmsocyfc	240	4	between	between	IN
cord-290566-tmsocyfc	240	5	integrin	integrin	NN
cord-290566-tmsocyfc	240	6	molecule	molecule	NN
cord-290566-tmsocyfc	240	7	41	41	CD
cord-290566-tmsocyfc	240	8	present	present	NN
cord-290566-tmsocyfc	240	9	on	on	IN
cord-290566-tmsocyfc	240	10	the	the	DT
cord-290566-tmsocyfc	240	11	surface	surface	NN
cord-290566-tmsocyfc	240	12	of	of	IN
cord-290566-tmsocyfc	240	13	T	t	NN
cord-290566-tmsocyfc	240	14	cells	cell	NNS
cord-290566-tmsocyfc	240	15	with	with	IN
cord-290566-tmsocyfc	240	16	VCAM-1	VCAM-1	NNP
cord-290566-tmsocyfc	240	17	present	present	JJ
cord-290566-tmsocyfc	240	18	on	on	IN
cord-290566-tmsocyfc	240	19	endothelial	endothelial	JJ
cord-290566-tmsocyfc	240	20	cells	cell	NNS
cord-290566-tmsocyfc	240	21	of	of	IN
cord-290566-tmsocyfc	240	22	the	the	DT
cord-290566-tmsocyfc	240	23	BBB	BBB	NNP
cord-290566-tmsocyfc	240	24	was	be	VBD
cord-290566-tmsocyfc	240	25	shown	show	VBN
cord-290566-tmsocyfc	240	26	to	to	TO
cord-290566-tmsocyfc	240	27	suppress	suppress	VB
cord-290566-tmsocyfc	240	28	the	the	DT
cord-290566-tmsocyfc	240	29	development	development	NN
cord-290566-tmsocyfc	240	30	of	of	IN
cord-290566-tmsocyfc	240	31	EAE	EAE	NNP
cord-290566-tmsocyfc	240	32	(	(	-LRB-
cord-290566-tmsocyfc	240	33	Yednock	Yednock	NNP
cord-290566-tmsocyfc	240	34	et	et	NNP
cord-290566-tmsocyfc	240	35	al	al	NNP
cord-290566-tmsocyfc	240	36	.	.	NNP
cord-290566-tmsocyfc	240	37	,	,	,
cord-290566-tmsocyfc	240	38	1992	1992	CD
cord-290566-tmsocyfc	240	39	)	)	-RRB-
cord-290566-tmsocyfc	240	40	.	.	.
cord-290566-tmsocyfc	241	1	This	this	DT
cord-290566-tmsocyfc	241	2	led	lead	VBD
cord-290566-tmsocyfc	241	3	to	to	IN
cord-290566-tmsocyfc	241	4	the	the	DT
cord-290566-tmsocyfc	241	5	development	development	NN
cord-290566-tmsocyfc	241	6	of	of	IN
cord-290566-tmsocyfc	241	7	an	an	DT
cord-290566-tmsocyfc	241	8	41-integrin	41-integrin	CD
cord-290566-tmsocyfc	241	9	antibody	antibody	NN
cord-290566-tmsocyfc	241	10	,	,	,
cord-290566-tmsocyfc	241	11	natalizumab	natalizumab	NNP
cord-290566-tmsocyfc	241	12	,	,	,
cord-290566-tmsocyfc	241	13	which	which	WDT
cord-290566-tmsocyfc	241	14	has	have	VBZ
cord-290566-tmsocyfc	241	15	been	be	VBN
cord-290566-tmsocyfc	241	16	eVective	eVective	NNP
cord-290566-tmsocyfc	241	17	in	in	IN
cord-290566-tmsocyfc	241	18	reducing	reduce	VBG
cord-290566-tmsocyfc	241	19	MS	MS	NNP
cord-290566-tmsocyfc	241	20	relapses	relapse	NNS
cord-290566-tmsocyfc	241	21	(	(	-LRB-
cord-290566-tmsocyfc	242	1	Miller	Miller	NNP
cord-290566-tmsocyfc	242	2	et	et	NNP
cord-290566-tmsocyfc	242	3	al	al	NNP
cord-290566-tmsocyfc	242	4	.	.	NNP
cord-290566-tmsocyfc	242	5	,	,	,
cord-290566-tmsocyfc	242	6	2003	2003	CD
cord-290566-tmsocyfc	242	7	)	)	-RRB-
cord-290566-tmsocyfc	242	8	.	.	.
cord-290566-tmsocyfc	243	1	However	however	RB
cord-290566-tmsocyfc	243	2	,	,	,
cord-290566-tmsocyfc	243	3	clinical	clinical	JJ
cord-290566-tmsocyfc	243	4	trials	trial	NNS
cord-290566-tmsocyfc	243	5	with	with	IN
cord-290566-tmsocyfc	243	6	a	a	DT
cord-290566-tmsocyfc	243	7	natalizumab	natalizumab	NNS
cord-290566-tmsocyfc	243	8	led	lead	VBN
cord-290566-tmsocyfc	243	9	to	to	IN
cord-290566-tmsocyfc	243	10	several	several	JJ
cord-290566-tmsocyfc	243	11	cases	case	NNS
cord-290566-tmsocyfc	243	12	of	of	IN
cord-290566-tmsocyfc	243	13	progressive	progressive	JJ
cord-290566-tmsocyfc	243	14	multifocal	multifocal	JJ
cord-290566-tmsocyfc	243	15	leukoencephalopathy	leukoencephalopathy	NNS
cord-290566-tmsocyfc	243	16	,	,	,
cord-290566-tmsocyfc	243	17	resulting	result	VBG
cord-290566-tmsocyfc	243	18	in	in	IN
cord-290566-tmsocyfc	243	19	the	the	DT
cord-290566-tmsocyfc	243	20	reevaluation	reevaluation	NN
cord-290566-tmsocyfc	243	21	of	of	IN
cord-290566-tmsocyfc	243	22	the	the	DT
cord-290566-tmsocyfc	243	23	role	role	NN
cord-290566-tmsocyfc	243	24	of	of	IN
cord-290566-tmsocyfc	243	25	such	such	JJ
cord-290566-tmsocyfc	243	26	drugs	drug	NNS
cord-290566-tmsocyfc	243	27	in	in	IN
cord-290566-tmsocyfc	243	28	MS	MS	NNP
cord-290566-tmsocyfc	243	29	therapeutics	therapeutic	NNS
cord-290566-tmsocyfc	243	30	(	(	-LRB-
cord-290566-tmsocyfc	243	31	Kleinschmidt	Kleinschmidt	NNP
cord-290566-tmsocyfc	243	32	-	-	HYPH
cord-290566-tmsocyfc	243	33	Demasters	Demasters	NNPS
cord-290566-tmsocyfc	243	34	and	and	CC
cord-290566-tmsocyfc	243	35	Tyler	Tyler	NNP
cord-290566-tmsocyfc	243	36	,	,	,
cord-290566-tmsocyfc	243	37	2005	2005	CD
cord-290566-tmsocyfc	243	38	;	;	:
cord-290566-tmsocyfc	244	1	Langer	Langer	NNP
cord-290566-tmsocyfc	244	2	-	-	HYPH
cord-290566-tmsocyfc	244	3	Gould	Gould	NNP
cord-290566-tmsocyfc	244	4	et	et	NNP
cord-290566-tmsocyfc	244	5	al	al	NNP
cord-290566-tmsocyfc	244	6	.	.	.
cord-290566-tmsocyfc	245	1	,	,	,
cord-290566-tmsocyfc	245	2	2005	2005	CD
cord-290566-tmsocyfc	245	3	;	;	:
cord-290566-tmsocyfc	245	4	Van	Van	NNP
cord-290566-tmsocyfc	245	5	Assche	Assche	NNP
cord-290566-tmsocyfc	245	6	et	et	NNP
cord-290566-tmsocyfc	245	7	al	al	NNP
cord-290566-tmsocyfc	245	8	.	.	NNP
cord-290566-tmsocyfc	245	9	,	,	,
cord-290566-tmsocyfc	245	10	2005	2005	CD
cord-290566-tmsocyfc	245	11	)	)	-RRB-
cord-290566-tmsocyfc	245	12	.	.	.
cord-290566-tmsocyfc	246	1	CXCR3	CXCR3	NNP
cord-290566-tmsocyfc	246	2	is	be	VBZ
cord-290566-tmsocyfc	246	3	postulated	postulate	VBN
cord-290566-tmsocyfc	246	4	to	to	TO
cord-290566-tmsocyfc	246	5	be	be	VB
cord-290566-tmsocyfc	246	6	the	the	DT
cord-290566-tmsocyfc	246	7	major	major	JJ
cord-290566-tmsocyfc	246	8	chemokine	chemokine	NN
cord-290566-tmsocyfc	246	9	involved	involve	VBN
cord-290566-tmsocyfc	246	10	in	in	IN
cord-290566-tmsocyfc	246	11	the	the	DT
cord-290566-tmsocyfc	246	12	traYcking	traycking	NN
cord-290566-tmsocyfc	246	13	of	of	IN
cord-290566-tmsocyfc	246	14	T	T	NNP
cord-290566-tmsocyfc	246	15	cells	cell	NNS
cord-290566-tmsocyfc	246	16	from	from	IN
cord-290566-tmsocyfc	246	17	the	the	DT
cord-290566-tmsocyfc	246	18	blood	blood	NN
cord-290566-tmsocyfc	246	19	to	to	IN
cord-290566-tmsocyfc	246	20	the	the	DT
cord-290566-tmsocyfc	246	21	CSF	CSF	NNP
cord-290566-tmsocyfc	246	22	for	for	IN
cord-290566-tmsocyfc	246	23	immunosurveillance	immunosurveillance	NN
cord-290566-tmsocyfc	246	24	in	in	IN
cord-290566-tmsocyfc	246	25	both	both	DT
cord-290566-tmsocyfc	246	26	normals	normal	NNS
cord-290566-tmsocyfc	246	27	and	and	CC
cord-290566-tmsocyfc	246	28	MS	MS	NNP
cord-290566-tmsocyfc	246	29	patients	patient	NNS
cord-290566-tmsocyfc	247	1	(	(	-LRB-
cord-290566-tmsocyfc	247	2	Kivisakk	Kivisakk	NNP
cord-290566-tmsocyfc	247	3	et	et	NNP
cord-290566-tmsocyfc	247	4	al	al	NNP
cord-290566-tmsocyfc	247	5	.	.	NNP
cord-290566-tmsocyfc	247	6	,	,	,
cord-290566-tmsocyfc	247	7	2002	2002	CD
cord-290566-tmsocyfc	247	8	)	)	-RRB-
cord-290566-tmsocyfc	247	9	.	.	.
cord-290566-tmsocyfc	248	1	Studies	study	NNS
cord-290566-tmsocyfc	248	2	of	of	IN
cord-290566-tmsocyfc	248	3	chemokine	chemokine	JJ
cord-290566-tmsocyfc	248	4	expression	expression	NN
cord-290566-tmsocyfc	248	5	on	on	IN
cord-290566-tmsocyfc	248	6	peripheral	peripheral	JJ
cord-290566-tmsocyfc	248	7	blood	blood	NN
cord-290566-tmsocyfc	248	8	T	T	NNP
cord-290566-tmsocyfc	248	9	cells	cell	NNS
cord-290566-tmsocyfc	248	10	in	in	IN
cord-290566-tmsocyfc	248	11	MS	MS	NNP
cord-290566-tmsocyfc	248	12	patients	patient	NNS
cord-290566-tmsocyfc	248	13	found	find	VBD
cord-290566-tmsocyfc	248	14	a	a	DT
cord-290566-tmsocyfc	248	15	positive	positive	JJ
cord-290566-tmsocyfc	248	16	correlation	correlation	NN
cord-290566-tmsocyfc	248	17	between	between	IN
cord-290566-tmsocyfc	248	18	CXCR3	cxcr3	NN
cord-290566-tmsocyfc	248	19	expression	expression	NN
cord-290566-tmsocyfc	248	20	on	on	IN
cord-290566-tmsocyfc	248	21	blood	blood	NN
cord-290566-tmsocyfc	248	22	T	t	NN
cord-290566-tmsocyfc	248	23	cells	cell	NNS
cord-290566-tmsocyfc	249	1	(	(	-LRB-
cord-290566-tmsocyfc	249	2	Eikelenboom	Eikelenboom	NNP
cord-290566-tmsocyfc	249	3	et	et	NNP
cord-290566-tmsocyfc	249	4	al	al	NNP
cord-290566-tmsocyfc	249	5	.	.	NNP
cord-290566-tmsocyfc	249	6	,	,	,
cord-290566-tmsocyfc	249	7	2002	2002	CD
cord-290566-tmsocyfc	249	8	)	)	-RRB-
cord-290566-tmsocyfc	249	9	and	and	CC
cord-290566-tmsocyfc	249	10	CSF	CSF	NNP
cord-290566-tmsocyfc	249	11	T	T	NNP
cord-290566-tmsocyfc	249	12	cells	cell	NNS
cord-290566-tmsocyfc	249	13	(	(	-LRB-
cord-290566-tmsocyfc	249	14	Sindern	Sindern	NNP
cord-290566-tmsocyfc	249	15	et	et	NNP
cord-290566-tmsocyfc	249	16	al	al	NNP
cord-290566-tmsocyfc	249	17	.	.	NNP
cord-290566-tmsocyfc	249	18	,	,	,
cord-290566-tmsocyfc	249	19	2002	2002	CD
cord-290566-tmsocyfc	249	20	)	)	-RRB-
cord-290566-tmsocyfc	249	21	on	on	IN
cord-290566-tmsocyfc	249	22	MRI	MRI	NNP
cord-290566-tmsocyfc	249	23	measures	measure	NNS
cord-290566-tmsocyfc	249	24	of	of	IN
cord-290566-tmsocyfc	249	25	disease	disease	NN
cord-290566-tmsocyfc	249	26	activity	activity	NN
cord-290566-tmsocyfc	249	27	in	in	IN
cord-290566-tmsocyfc	249	28	MS	MS	NNP
cord-290566-tmsocyfc	249	29	patients	patient	NNS
cord-290566-tmsocyfc	249	30	.	.	.
cord-290566-tmsocyfc	250	1	T	t	NN
cord-290566-tmsocyfc	250	2	-	-	HYPH
cord-290566-tmsocyfc	250	3	cell	cell	NN
cord-290566-tmsocyfc	250	4	migration	migration	NN
cord-290566-tmsocyfc	250	5	is	be	VBZ
cord-290566-tmsocyfc	250	6	an	an	DT
cord-290566-tmsocyfc	250	7	important	important	JJ
cord-290566-tmsocyfc	250	8	step	step	NN
cord-290566-tmsocyfc	250	9	in	in	IN
cord-290566-tmsocyfc	250	10	the	the	DT
cord-290566-tmsocyfc	250	11	pathogenesis	pathogenesis	NN
cord-290566-tmsocyfc	250	12	of	of	IN
cord-290566-tmsocyfc	250	13	MS	MS	NNP
cord-290566-tmsocyfc	250	14	,	,	,
cord-290566-tmsocyfc	250	15	as	as	IN
cord-290566-tmsocyfc	250	16	confirmed	confirm	VBN
cord-290566-tmsocyfc	250	17	by	by	IN
cord-290566-tmsocyfc	250	18	the	the	DT
cord-290566-tmsocyfc	250	19	success	success	NN
cord-290566-tmsocyfc	250	20	of	of	IN
cord-290566-tmsocyfc	250	21	41-integrin	41-integrin	CD
cord-290566-tmsocyfc	250	22	antibody	antibody	NN
cord-290566-tmsocyfc	250	23	therapy	therapy	NN
cord-290566-tmsocyfc	250	24	(	(	-LRB-
cord-290566-tmsocyfc	250	25	natalizumab	natalizumab	NNP
cord-290566-tmsocyfc	250	26	)	)	-RRB-
cord-290566-tmsocyfc	250	27	.	.	.
cord-290566-tmsocyfc	251	1	However	however	RB
cord-290566-tmsocyfc	251	2	,	,	,
cord-290566-tmsocyfc	251	3	eVective	eVective	NNP
cord-290566-tmsocyfc	251	4	blockade	blockade	NN
cord-290566-tmsocyfc	251	5	of	of	IN
cord-290566-tmsocyfc	251	6	CNS	CNS	NNP
cord-290566-tmsocyfc	251	7	immunosurveillance	immunosurveillance	NN
cord-290566-tmsocyfc	251	8	has	have	VBZ
cord-290566-tmsocyfc	251	9	produced	produce	VBN
cord-290566-tmsocyfc	251	10	profound	profound	JJ
cord-290566-tmsocyfc	251	11	adverse	adverse	JJ
cord-290566-tmsocyfc	251	12	eVects	evect	NNS
cord-290566-tmsocyfc	251	13	,	,	,
cord-290566-tmsocyfc	251	14	as	as	IN
cord-290566-tmsocyfc	251	15	evidenced	evidence	VBN
cord-290566-tmsocyfc	251	16	by	by	IN
cord-290566-tmsocyfc	251	17	the	the	DT
cord-290566-tmsocyfc	251	18	development	development	NN
cord-290566-tmsocyfc	251	19	of	of	IN
cord-290566-tmsocyfc	251	20	PML	PML	NNP
cord-290566-tmsocyfc	251	21	in	in	IN
cord-290566-tmsocyfc	251	22	three	three	CD
cord-290566-tmsocyfc	251	23	treated	treat	VBN
cord-290566-tmsocyfc	251	24	patients	patient	NNS
cord-290566-tmsocyfc	251	25	.	.	.
cord-290566-tmsocyfc	252	1	The	the	DT
cord-290566-tmsocyfc	252	2	risk	risk	NN
cord-290566-tmsocyfc	252	3	of	of	IN
cord-290566-tmsocyfc	252	4	infection	infection	NN
cord-290566-tmsocyfc	252	5	and	and	CC
cord-290566-tmsocyfc	252	6	emergence	emergence	NN
cord-290566-tmsocyfc	252	7	of	of	IN
cord-290566-tmsocyfc	252	8	tumors	tumor	NNS
cord-290566-tmsocyfc	252	9	due	due	JJ
cord-290566-tmsocyfc	252	10	to	to	IN
cord-290566-tmsocyfc	252	11	blockade	blockade	NN
cord-290566-tmsocyfc	252	12	of	of	IN
cord-290566-tmsocyfc	252	13	immunosurveillance	immunosurveillance	NN
cord-290566-tmsocyfc	252	14	must	must	MD
cord-290566-tmsocyfc	252	15	be	be	VB
cord-290566-tmsocyfc	252	16	balanced	balance	VBN
cord-290566-tmsocyfc	252	17	with	with	IN
cord-290566-tmsocyfc	252	18	therapeutic	therapeutic	JJ
cord-290566-tmsocyfc	252	19	eVect	evect	NN
cord-290566-tmsocyfc	252	20	when	when	WRB
cord-290566-tmsocyfc	252	21	utilizing	utilize	VBG
cord-290566-tmsocyfc	252	22	such	such	JJ
cord-290566-tmsocyfc	252	23	powerful	powerful	JJ
cord-290566-tmsocyfc	252	24	therapeutics	therapeutic	NNS
cord-290566-tmsocyfc	252	25	.	.	.
cord-290566-tmsocyfc	253	1	Much	much	JJ
cord-290566-tmsocyfc	253	2	attention	attention	NN
cord-290566-tmsocyfc	253	3	has	have	VBZ
cord-290566-tmsocyfc	253	4	focused	focus	VBN
cord-290566-tmsocyfc	253	5	on	on	IN
cord-290566-tmsocyfc	253	6	the	the	DT
cord-290566-tmsocyfc	253	7	presence	presence	NN
cord-290566-tmsocyfc	253	8	of	of	IN
cord-290566-tmsocyfc	253	9	axonal	axonal	JJ
cord-290566-tmsocyfc	253	10	damage	damage	NN
cord-290566-tmsocyfc	253	11	in	in	IN
cord-290566-tmsocyfc	253	12	MS	MS	NNP
cord-290566-tmsocyfc	253	13	plaques	plaque	NNS
cord-290566-tmsocyfc	253	14	as	as	IN
cord-290566-tmsocyfc	253	15	a	a	DT
cord-290566-tmsocyfc	253	16	substrate	substrate	NN
cord-290566-tmsocyfc	253	17	for	for	IN
cord-290566-tmsocyfc	253	18	chronic	chronic	JJ
cord-290566-tmsocyfc	253	19	progressive	progressive	JJ
cord-290566-tmsocyfc	253	20	disease	disease	NN
cord-290566-tmsocyfc	253	21	(	(	-LRB-
cord-290566-tmsocyfc	253	22	Trapp	Trapp	NNP
cord-290566-tmsocyfc	253	23	et	et	NNP
cord-290566-tmsocyfc	253	24	al	al	NNP
cord-290566-tmsocyfc	253	25	.	.	NNP
cord-290566-tmsocyfc	253	26	,	,	,
cord-290566-tmsocyfc	253	27	1998	1998	CD
cord-290566-tmsocyfc	254	1	(	(	-LRB-
cord-290566-tmsocyfc	254	2	Trapp	Trapp	NNP
cord-290566-tmsocyfc	254	3	et	et	NNP
cord-290566-tmsocyfc	254	4	al	al	NNP
cord-290566-tmsocyfc	254	5	.	.	NNP
cord-290566-tmsocyfc	254	6	,	,	,
cord-290566-tmsocyfc	254	7	,	,	,
cord-290566-tmsocyfc	254	8	1999	1999	CD
cord-290566-tmsocyfc	254	9	.	.	.
cord-290566-tmsocyfc	255	1	Although	although	IN
cord-290566-tmsocyfc	255	2	mediators	mediator	NNS
cord-290566-tmsocyfc	255	3	of	of	IN
cord-290566-tmsocyfc	255	4	axonal	axonal	JJ
cord-290566-tmsocyfc	255	5	damage	damage	NN
cord-290566-tmsocyfc	255	6	include	include	VBP
cord-290566-tmsocyfc	255	7	cytokines	cytokine	NNS
cord-290566-tmsocyfc	255	8	,	,	,
cord-290566-tmsocyfc	255	9	complement	complement	NN
cord-290566-tmsocyfc	255	10	,	,	,
cord-290566-tmsocyfc	255	11	antibody	antibody	NN
cord-290566-tmsocyfc	255	12	,	,	,
cord-290566-tmsocyfc	255	13	and	and	CC
cord-290566-tmsocyfc	255	14	nitric	nitric	JJ
cord-290566-tmsocyfc	255	15	oxide	oxide	NN
cord-290566-tmsocyfc	255	16	,	,	,
cord-290566-tmsocyfc	255	17	T	t	NN
cord-290566-tmsocyfc	255	18	cells	cell	NNS
cord-290566-tmsocyfc	255	19	may	may	MD
cord-290566-tmsocyfc	255	20	play	play	VB
cord-290566-tmsocyfc	255	21	a	a	DT
cord-290566-tmsocyfc	255	22	significant	significant	JJ
cord-290566-tmsocyfc	255	23	role	role	NN
cord-290566-tmsocyfc	255	24	both	both	CC
cord-290566-tmsocyfc	255	25	in	in	IN
cord-290566-tmsocyfc	255	26	neurodegeneration	neurodegeneration	NN
cord-290566-tmsocyfc	255	27	and	and	CC
cord-290566-tmsocyfc	255	28	in	in	IN
cord-290566-tmsocyfc	255	29	neuroprotection	neuroprotection	NN
cord-290566-tmsocyfc	255	30	.	.	.
cord-290566-tmsocyfc	256	1	The	the	DT
cord-290566-tmsocyfc	256	2	presence	presence	NN
cord-290566-tmsocyfc	256	3	of	of	IN
cord-290566-tmsocyfc	256	4	CD8þ	CD8þ	NNP
cord-290566-tmsocyfc	256	5	T	T	NNP
cord-290566-tmsocyfc	256	6	cells	cell	NNS
cord-290566-tmsocyfc	256	7	,	,	,
cord-290566-tmsocyfc	256	8	but	but	CC
cord-290566-tmsocyfc	256	9	not	not	RB
cord-290566-tmsocyfc	256	10	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	256	11	T	T	NNP
cord-290566-tmsocyfc	256	12	cells	cell	NNS
cord-290566-tmsocyfc	256	13	,	,	,
cord-290566-tmsocyfc	256	14	in	in	IN
cord-290566-tmsocyfc	256	15	the	the	DT
cord-290566-tmsocyfc	256	16	MS	MS	NNP
cord-290566-tmsocyfc	256	17	lesion	lesion	NN
cord-290566-tmsocyfc	256	18	correlates	correlate	VBZ
cord-290566-tmsocyfc	256	19	with	with	IN
cord-290566-tmsocyfc	256	20	axonal	axonal	JJ
cord-290566-tmsocyfc	256	21	damage	damage	NN
cord-290566-tmsocyfc	257	1	(	(	-LRB-
cord-290566-tmsocyfc	257	2	Bitsch	Bitsch	NNP
cord-290566-tmsocyfc	257	3	et	et	NNP
cord-290566-tmsocyfc	257	4	al	al	NNP
cord-290566-tmsocyfc	257	5	.	.	NNP
cord-290566-tmsocyfc	257	6	,	,	,
cord-290566-tmsocyfc	257	7	2000	2000	CD
cord-290566-tmsocyfc	257	8	)	)	-RRB-
cord-290566-tmsocyfc	257	9	.	.	.
cord-290566-tmsocyfc	258	1	In	in	IN
cord-290566-tmsocyfc	258	2	the	the	DT
cord-290566-tmsocyfc	258	3	TMEV	TMEV	NNP
cord-290566-tmsocyfc	258	4	model	model	NN
cord-290566-tmsocyfc	258	5	of	of	IN
cord-290566-tmsocyfc	258	6	MS	MS	NNP
cord-290566-tmsocyfc	258	7	,	,	,
cord-290566-tmsocyfc	258	8	demyelination	demyelination	NN
cord-290566-tmsocyfc	258	9	but	but	CC
cord-290566-tmsocyfc	258	10	no	no	DT
cord-290566-tmsocyfc	258	11	axonal	axonal	JJ
cord-290566-tmsocyfc	258	12	damage	damage	NN
cord-290566-tmsocyfc	258	13	was	be	VBD
cord-290566-tmsocyfc	258	14	found	find	VBN
cord-290566-tmsocyfc	258	15	in	in	IN
cord-290566-tmsocyfc	258	16	the	the	DT
cord-290566-tmsocyfc	258	17	CNS	CNS	NNP
cord-290566-tmsocyfc	258	18	of	of	IN
cord-290566-tmsocyfc	258	19	MHC	MHC	NNP
cord-290566-tmsocyfc	258	20	class	class	NN
cord-290566-tmsocyfc	258	21	I	i	NN
cord-290566-tmsocyfc	258	22	-	-	HYPH
cord-290566-tmsocyfc	258	23	deficient	deficient	JJ
cord-290566-tmsocyfc	258	24	mice	mouse	NNS
cord-290566-tmsocyfc	258	25	after	after	IN
cord-290566-tmsocyfc	258	26	infection	infection	NN
cord-290566-tmsocyfc	258	27	with	with	IN
cord-290566-tmsocyfc	258	28	Theiler	Theiler	NNP
cord-290566-tmsocyfc	258	29	's	's	POS
cord-290566-tmsocyfc	258	30	virus	virus	NN
cord-290566-tmsocyfc	258	31	(	(	-LRB-
cord-290566-tmsocyfc	258	32	Rivera	Rivera	NNP
cord-290566-tmsocyfc	258	33	-	-	HYPH
cord-290566-tmsocyfc	258	34	Quinones	Quinones	NNP
cord-290566-tmsocyfc	258	35	et	et	NNP
cord-290566-tmsocyfc	258	36	al	al	NNP
cord-290566-tmsocyfc	258	37	.	.	NNP
cord-290566-tmsocyfc	258	38	,	,	,
cord-290566-tmsocyfc	258	39	1998	1998	CD
cord-290566-tmsocyfc	258	40	)	)	-RRB-
cord-290566-tmsocyfc	258	41	,	,	,
cord-290566-tmsocyfc	258	42	suggesting	suggest	VBG
cord-290566-tmsocyfc	258	43	that	that	IN
cord-290566-tmsocyfc	258	44	axonal	axonal	JJ
cord-290566-tmsocyfc	258	45	damage	damage	NN
cord-290566-tmsocyfc	258	46	is	be	VBZ
cord-290566-tmsocyfc	258	47	class	class	NN
cord-290566-tmsocyfc	258	48	I	-PRON-	PRP
cord-290566-tmsocyfc	258	49	mediated	mediate	VBD
cord-290566-tmsocyfc	258	50	.	.	.
cord-290566-tmsocyfc	259	1	These	these	DT
cord-290566-tmsocyfc	259	2	mice	mouse	NNS
cord-290566-tmsocyfc	259	3	also	also	RB
cord-290566-tmsocyfc	259	4	displayed	display	VBD
cord-290566-tmsocyfc	259	5	a	a	DT
cord-290566-tmsocyfc	259	6	deficiency	deficiency	NN
cord-290566-tmsocyfc	259	7	of	of	IN
cord-290566-tmsocyfc	259	8	CD8-positive	cd8-positive	JJ
cord-290566-tmsocyfc	259	9	cells	cell	NNS
cord-290566-tmsocyfc	259	10	in	in	IN
cord-290566-tmsocyfc	259	11	their	-PRON-	PRP$
cord-290566-tmsocyfc	259	12	CNS	CNS	NNP
cord-290566-tmsocyfc	259	13	lesions	lesion	NNS
cord-290566-tmsocyfc	259	14	.	.	.
cord-290566-tmsocyfc	260	1	Similarly	similarly	RB
cord-290566-tmsocyfc	260	2	,	,	,
cord-290566-tmsocyfc	260	3	in	in	IN
cord-290566-tmsocyfc	260	4	vitro	vitro	FW
cord-290566-tmsocyfc	260	5	,	,	,
cord-290566-tmsocyfc	260	6	T	T	NNP
cord-290566-tmsocyfc	260	7	cell	cell	NN
cord-290566-tmsocyfc	260	8	-	-	HYPH
cord-290566-tmsocyfc	260	9	mediated	mediate	VBN
cord-290566-tmsocyfc	260	10	neurotoxicity	neurotoxicity	NN
cord-290566-tmsocyfc	260	11	was	be	VBD
cord-290566-tmsocyfc	260	12	dependent	dependent	JJ
cord-290566-tmsocyfc	260	13	on	on	IN
cord-290566-tmsocyfc	260	14	IFN	IFN	NNP
cord-290566-tmsocyfc	260	15	--	--	:
cord-290566-tmsocyfc	260	16	induced	induce	VBN
cord-290566-tmsocyfc	260	17	expression	expression	NN
cord-290566-tmsocyfc	260	18	of	of	IN
cord-290566-tmsocyfc	260	19	MHC	MHC	NNP
cord-290566-tmsocyfc	260	20	class	class	NN
cord-290566-tmsocyfc	260	21	I	i	NN
cord-290566-tmsocyfc	260	22	(	(	-LRB-
cord-290566-tmsocyfc	260	23	Medana	Medana	NNP
cord-290566-tmsocyfc	260	24	et	et	NNP
cord-290566-tmsocyfc	260	25	al	al	NNP
cord-290566-tmsocyfc	260	26	.	.	NNP
cord-290566-tmsocyfc	260	27	,	,	,
cord-290566-tmsocyfc	260	28	2001	2001	CD
cord-290566-tmsocyfc	260	29	)	)	-RRB-
cord-290566-tmsocyfc	260	30	.	.	.
cord-290566-tmsocyfc	261	1	Collectively	collectively	RB
cord-290566-tmsocyfc	261	2	,	,	,
cord-290566-tmsocyfc	261	3	these	these	DT
cord-290566-tmsocyfc	261	4	studies	study	NNS
cord-290566-tmsocyfc	261	5	suggest	suggest	VBP
cord-290566-tmsocyfc	261	6	that	that	DT
cord-290566-tmsocyfc	261	7	class	class	NN
cord-290566-tmsocyfc	261	8	I	-PRON-	PRP
cord-290566-tmsocyfc	261	9	expression	expression	NN
cord-290566-tmsocyfc	261	10	in	in	IN
cord-290566-tmsocyfc	261	11	the	the	DT
cord-290566-tmsocyfc	261	12	CNS	CNS	NNP
cord-290566-tmsocyfc	261	13	,	,	,
cord-290566-tmsocyfc	261	14	particularly	particularly	RB
cord-290566-tmsocyfc	261	15	on	on	IN
cord-290566-tmsocyfc	261	16	neurons	neuron	NNS
cord-290566-tmsocyfc	261	17	,	,	,
cord-290566-tmsocyfc	261	18	may	may	MD
cord-290566-tmsocyfc	261	19	enhance	enhance	VB
cord-290566-tmsocyfc	261	20	a	a	DT
cord-290566-tmsocyfc	261	21	cytotoxic	cytotoxic	JJ
cord-290566-tmsocyfc	261	22	CD8þ	CD8þ	NNP
cord-290566-tmsocyfc	261	23	T	t	NN
cord-290566-tmsocyfc	261	24	-	-	HYPH
cord-290566-tmsocyfc	261	25	cell	cell	NN
cord-290566-tmsocyfc	261	26	response	response	NN
cord-290566-tmsocyfc	261	27	.	.	.
cord-290566-tmsocyfc	262	1	In	in	IN
cord-290566-tmsocyfc	262	2	vitro	vitro	FW
cord-290566-tmsocyfc	262	3	coculture	coculture	NN
cord-290566-tmsocyfc	262	4	of	of	IN
cord-290566-tmsocyfc	262	5	human	human	JJ
cord-290566-tmsocyfc	262	6	fetal	fetal	JJ
cord-290566-tmsocyfc	262	7	neurons	neuron	NNS
cord-290566-tmsocyfc	262	8	with	with	IN
cord-290566-tmsocyfc	262	9	OKT3-activated	OKT3-activated	NNP
cord-290566-tmsocyfc	262	10	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	262	11	or	or	CC
cord-290566-tmsocyfc	262	12	CD8þ	CD8þ	NNP
cord-290566-tmsocyfc	262	13	T	T	NNP
cord-290566-tmsocyfc	262	14	cells	cell	NNS
cord-290566-tmsocyfc	262	15	has	have	VBZ
cord-290566-tmsocyfc	262	16	been	be	VBN
cord-290566-tmsocyfc	262	17	found	find	VBN
cord-290566-tmsocyfc	262	18	to	to	TO
cord-290566-tmsocyfc	262	19	produce	produce	VB
cord-290566-tmsocyfc	262	20	apoptosis	apoptosis	NN
cord-290566-tmsocyfc	262	21	of	of	IN
cord-290566-tmsocyfc	262	22	neurons	neuron	NNS
cord-290566-tmsocyfc	263	1	(	(	-LRB-
cord-290566-tmsocyfc	263	2	Giuliani	Giuliani	NNP
cord-290566-tmsocyfc	263	3	et	et	NNP
cord-290566-tmsocyfc	263	4	al	al	NNP
cord-290566-tmsocyfc	263	5	.	.	NNP
cord-290566-tmsocyfc	263	6	,	,	,
cord-290566-tmsocyfc	263	7	2003	2003	CD
cord-290566-tmsocyfc	263	8	)	)	-RRB-
cord-290566-tmsocyfc	263	9	.	.	.
cord-290566-tmsocyfc	264	1	This	this	DT
cord-290566-tmsocyfc	264	2	process	process	NN
cord-290566-tmsocyfc	264	3	required	require	VBD
cord-290566-tmsocyfc	264	4	physical	physical	JJ
cord-290566-tmsocyfc	264	5	contact	contact	NN
cord-290566-tmsocyfc	264	6	of	of	IN
cord-290566-tmsocyfc	264	7	the	the	DT
cord-290566-tmsocyfc	264	8	cells	cell	NNS
cord-290566-tmsocyfc	264	9	,	,	,
cord-290566-tmsocyfc	264	10	as	as	IN
cord-290566-tmsocyfc	264	11	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	264	12	by	by	IN
cord-290566-tmsocyfc	264	13	transwell	transwell	NNP
cord-290566-tmsocyfc	264	14	experiments	experiment	NNS
cord-290566-tmsocyfc	264	15	,	,	,
cord-290566-tmsocyfc	264	16	and	and	CC
cord-290566-tmsocyfc	264	17	was	be	VBD
cord-290566-tmsocyfc	264	18	not	not	RB
cord-290566-tmsocyfc	264	19	dependent	dependent	JJ
cord-290566-tmsocyfc	264	20	on	on	IN
cord-290566-tmsocyfc	264	21	MHC	MHC	NNP
cord-290566-tmsocyfc	264	22	I.	I.	NNP
cord-290566-tmsocyfc	264	23	Protection	Protection	NNP
cord-290566-tmsocyfc	264	24	could	could	MD
cord-290566-tmsocyfc	264	25	be	be	VB
cord-290566-tmsocyfc	264	26	conferred	confer	VBN
cord-290566-tmsocyfc	264	27	by	by	IN
cord-290566-tmsocyfc	264	28	blocking	block	VBG
cord-290566-tmsocyfc	264	29	CD40	CD40	NNP
cord-290566-tmsocyfc	264	30	on	on	IN
cord-290566-tmsocyfc	264	31	both	both	CC
cord-290566-tmsocyfc	264	32	T	t	NN
cord-290566-tmsocyfc	264	33	cells	cell	NNS
cord-290566-tmsocyfc	264	34	and	and	CC
cord-290566-tmsocyfc	264	35	neurons	neuron	NNS
cord-290566-tmsocyfc	264	36	,	,	,
cord-290566-tmsocyfc	264	37	and	and	CC
cord-290566-tmsocyfc	264	38	FasL	FasL	NNP
cord-290566-tmsocyfc	264	39	on	on	IN
cord-290566-tmsocyfc	264	40	neurons	neuron	NNS
cord-290566-tmsocyfc	264	41	.	.	.
cord-290566-tmsocyfc	265	1	Attention	attention	NN
cord-290566-tmsocyfc	265	2	has	have	VBZ
cord-290566-tmsocyfc	265	3	focused	focus	VBN
cord-290566-tmsocyfc	265	4	on	on	IN
cord-290566-tmsocyfc	265	5	the	the	DT
cord-290566-tmsocyfc	265	6	regulatory	regulatory	JJ
cord-290566-tmsocyfc	265	7	role	role	NN
cord-290566-tmsocyfc	265	8	that	that	IN
cord-290566-tmsocyfc	265	9	neurons	neuron	NNS
cord-290566-tmsocyfc	265	10	may	may	MD
cord-290566-tmsocyfc	265	11	play	play	VB
cord-290566-tmsocyfc	265	12	on	on	IN
cord-290566-tmsocyfc	265	13	T	t	NN
cord-290566-tmsocyfc	265	14	cells	cell	NNS
cord-290566-tmsocyfc	265	15	.	.	.
cord-290566-tmsocyfc	266	1	In	in	IN
cord-290566-tmsocyfc	266	2	a	a	DT
cord-290566-tmsocyfc	266	3	Lewis	Lewis	NNP
cord-290566-tmsocyfc	266	4	rat	rat	NN
cord-290566-tmsocyfc	266	5	model	model	NN
cord-290566-tmsocyfc	266	6	of	of	IN
cord-290566-tmsocyfc	266	7	EAE	EAE	NNP
cord-290566-tmsocyfc	266	8	,	,	,
cord-290566-tmsocyfc	266	9	motoneurons	motoneuron	NNS
cord-290566-tmsocyfc	266	10	were	be	VBD
cord-290566-tmsocyfc	266	11	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	266	12	to	to	TO
cord-290566-tmsocyfc	266	13	engulf	engulf	VB
cord-290566-tmsocyfc	266	14	T	t	NN
cord-290566-tmsocyfc	266	15	lymphocytes	lymphocyte	NNS
cord-290566-tmsocyfc	266	16	through	through	IN
cord-290566-tmsocyfc	266	17	a	a	DT
cord-290566-tmsocyfc	266	18	process	process	NN
cord-290566-tmsocyfc	266	19	consistent	consistent	JJ
cord-290566-tmsocyfc	266	20	with	with	IN
cord-290566-tmsocyfc	266	21	emperipolesis	emperipolesis	NNP
cord-290566-tmsocyfc	266	22	(	(	-LRB-
cord-290566-tmsocyfc	266	23	Smith	Smith	NNP
cord-290566-tmsocyfc	266	24	et	et	NNP
cord-290566-tmsocyfc	266	25	al	al	NNP
cord-290566-tmsocyfc	266	26	.	.	NNP
cord-290566-tmsocyfc	266	27	,	,	,
cord-290566-tmsocyfc	266	28	2000	2000	CD
cord-290566-tmsocyfc	266	29	)	)	-RRB-
cord-290566-tmsocyfc	266	30	.	.	.
cord-290566-tmsocyfc	267	1	Neuronal	neuronal	JJ
cord-290566-tmsocyfc	267	2	production	production	NN
cord-290566-tmsocyfc	267	3	of	of	IN
cord-290566-tmsocyfc	267	4	TGF	TGF	NNP
cord-290566-tmsocyfc	267	5	-	-	:
cord-290566-tmsocyfc	267	6	has	have	VBZ
cord-290566-tmsocyfc	267	7	been	be	VBN
cord-290566-tmsocyfc	267	8	shown	show	VBN
cord-290566-tmsocyfc	267	9	to	to	TO
cord-290566-tmsocyfc	267	10	play	play	VB
cord-290566-tmsocyfc	267	11	a	a	DT
cord-290566-tmsocyfc	267	12	significant	significant	JJ
cord-290566-tmsocyfc	267	13	role	role	NN
cord-290566-tmsocyfc	267	14	in	in	IN
cord-290566-tmsocyfc	267	15	the	the	DT
cord-290566-tmsocyfc	267	16	induction	induction	NN
cord-290566-tmsocyfc	267	17	of	of	IN
cord-290566-tmsocyfc	267	18	CD4þCD25þFoxp3þ	CD4þCD25þFoxp3þ	NNP
cord-290566-tmsocyfc	267	19	regulatory	regulatory	JJ
cord-290566-tmsocyfc	267	20	T	t	NN
cord-290566-tmsocyfc	267	21	cells	cell	NNS
cord-290566-tmsocyfc	267	22	in	in	IN
cord-290566-tmsocyfc	267	23	a	a	DT
cord-290566-tmsocyfc	267	24	murine	murine	JJ
cord-290566-tmsocyfc	267	25	EAE	EAE	NNP
cord-290566-tmsocyfc	267	26	model	model	NN
cord-290566-tmsocyfc	268	1	(	(	-LRB-
cord-290566-tmsocyfc	268	2	Liu	Liu	NNP
cord-290566-tmsocyfc	268	3	et	et	NNP
cord-290566-tmsocyfc	268	4	al	al	NNP
cord-290566-tmsocyfc	268	5	.	.	NNP
cord-290566-tmsocyfc	268	6	,	,	,
cord-290566-tmsocyfc	268	7	2006	2006	CD
cord-290566-tmsocyfc	268	8	)	)	-RRB-
cord-290566-tmsocyfc	268	9	.	.	.
cord-290566-tmsocyfc	269	1	These	these	DT
cord-290566-tmsocyfc	269	2	studies	study	NNS
cord-290566-tmsocyfc	269	3	have	have	VBP
cord-290566-tmsocyfc	269	4	important	important	JJ
cord-290566-tmsocyfc	269	5	implications	implication	NNS
cord-290566-tmsocyfc	269	6	for	for	IN
cord-290566-tmsocyfc	269	7	understanding	understand	VBG
cord-290566-tmsocyfc	269	8	the	the	DT
cord-290566-tmsocyfc	269	9	T	T	NNP
cord-290566-tmsocyfc	269	10	cell	cell	NN
cord-290566-tmsocyfc	269	11	-	-	HYPH
cord-290566-tmsocyfc	269	12	neuronal	neuronal	JJ
cord-290566-tmsocyfc	269	13	interactions	interaction	NNS
cord-290566-tmsocyfc	269	14	in	in	IN
cord-290566-tmsocyfc	269	15	MS	MS	NNP
cord-290566-tmsocyfc	269	16	.	.	.
cord-290566-tmsocyfc	270	1	Although	although	IN
cord-290566-tmsocyfc	270	2	MBP	MBP	NNP
cord-290566-tmsocyfc	270	3	-	-	HYPH
cord-290566-tmsocyfc	270	4	reactive	reactive	JJ
cord-290566-tmsocyfc	270	5	T	t	NN
cord-290566-tmsocyfc	270	6	cells	cell	NNS
cord-290566-tmsocyfc	270	7	have	have	VBP
cord-290566-tmsocyfc	270	8	been	be	VBN
cord-290566-tmsocyfc	270	9	implicated	implicate	VBN
cord-290566-tmsocyfc	270	10	in	in	IN
cord-290566-tmsocyfc	270	11	the	the	DT
cord-290566-tmsocyfc	270	12	pathogenesis	pathogenesis	NN
cord-290566-tmsocyfc	270	13	of	of	IN
cord-290566-tmsocyfc	270	14	MS	MS	NNP
cord-290566-tmsocyfc	270	15	(	(	-LRB-
cord-290566-tmsocyfc	270	16	Zhang	Zhang	NNP
cord-290566-tmsocyfc	270	17	et	et	NNP
cord-290566-tmsocyfc	270	18	al	al	NNP
cord-290566-tmsocyfc	270	19	.	.	NNP
cord-290566-tmsocyfc	270	20	,	,	,
cord-290566-tmsocyfc	270	21	1992	1992	CD
cord-290566-tmsocyfc	271	1	(	(	-LRB-
cord-290566-tmsocyfc	271	2	Zhang	Zhang	NNP
cord-290566-tmsocyfc	271	3	et	et	NNP
cord-290566-tmsocyfc	271	4	al	al	NNP
cord-290566-tmsocyfc	271	5	.	.	.
cord-290566-tmsocyfc	272	1	,	,	,
cord-290566-tmsocyfc	272	2	,	,	,
cord-290566-tmsocyfc	272	3	1994	1994	CD
cord-290566-tmsocyfc	272	4	,	,	,
cord-290566-tmsocyfc	272	5	an	an	DT
cord-290566-tmsocyfc	272	6	intriguing	intriguing	JJ
cord-290566-tmsocyfc	272	7	study	study	NN
cord-290566-tmsocyfc	272	8	has	have	VBZ
cord-290566-tmsocyfc	272	9	shown	show	VBN
cord-290566-tmsocyfc	272	10	that	that	IN
cord-290566-tmsocyfc	272	11	passive	passive	JJ
cord-290566-tmsocyfc	272	12	transfer	transfer	NN
cord-290566-tmsocyfc	272	13	of	of	IN
cord-290566-tmsocyfc	272	14	MBP	MBP	NNP
cord-290566-tmsocyfc	272	15	-	-	HYPH
cord-290566-tmsocyfc	272	16	reactive	reactive	JJ
cord-290566-tmsocyfc	272	17	T	T	NNP
cord-290566-tmsocyfc	272	18	cells	cell	NNS
cord-290566-tmsocyfc	272	19	resulted	result	VBD
cord-290566-tmsocyfc	272	20	in	in	IN
cord-290566-tmsocyfc	272	21	protection	protection	NN
cord-290566-tmsocyfc	272	22	of	of	IN
cord-290566-tmsocyfc	272	23	the	the	DT
cord-290566-tmsocyfc	272	24	retinal	retinal	JJ
cord-290566-tmsocyfc	272	25	ganglion	ganglion	NN
cord-290566-tmsocyfc	272	26	cell	cell	NN
cord-290566-tmsocyfc	272	27	body	body	NN
cord-290566-tmsocyfc	272	28	after	after	IN
cord-290566-tmsocyfc	272	29	optic	optic	JJ
cord-290566-tmsocyfc	272	30	nerve	nerve	NN
cord-290566-tmsocyfc	272	31	crush	crush	NN
cord-290566-tmsocyfc	272	32	injury	injury	NN
cord-290566-tmsocyfc	272	33	in	in	IN
cord-290566-tmsocyfc	272	34	vivo	vivo	NN
cord-290566-tmsocyfc	273	1	(	(	-LRB-
cord-290566-tmsocyfc	273	2	Moalem	Moalem	NNP
cord-290566-tmsocyfc	273	3	et	et	NNP
cord-290566-tmsocyfc	273	4	al	al	NNP
cord-290566-tmsocyfc	273	5	.	.	NNP
cord-290566-tmsocyfc	273	6	,	,	,
cord-290566-tmsocyfc	273	7	1999	1999	CD
cord-290566-tmsocyfc	273	8	)	)	-RRB-
cord-290566-tmsocyfc	273	9	.	.	.
cord-290566-tmsocyfc	274	1	Interestingly	interestingly	RB
cord-290566-tmsocyfc	274	2	,	,	,
cord-290566-tmsocyfc	274	3	transfer	transfer	NN
cord-290566-tmsocyfc	274	4	of	of	IN
cord-290566-tmsocyfc	274	5	T	t	NN
cord-290566-tmsocyfc	274	6	cells	cell	NNS
cord-290566-tmsocyfc	274	7	specific	specific	JJ
cord-290566-tmsocyfc	274	8	for	for	IN
cord-290566-tmsocyfc	274	9	other	other	JJ
cord-290566-tmsocyfc	274	10	antigens	antigen	NNS
cord-290566-tmsocyfc	274	11	was	be	VBD
cord-290566-tmsocyfc	274	12	not	not	RB
cord-290566-tmsocyfc	274	13	protective	protective	JJ
cord-290566-tmsocyfc	274	14	.	.	.
cord-290566-tmsocyfc	275	1	Furthermore	furthermore	RB
cord-290566-tmsocyfc	275	2	,	,	,
cord-290566-tmsocyfc	275	3	expression	expression	NN
cord-290566-tmsocyfc	275	4	of	of	IN
cord-290566-tmsocyfc	275	5	mRNA	mrna	NN
cord-290566-tmsocyfc	275	6	for	for	IN
cord-290566-tmsocyfc	275	7	several	several	JJ
cord-290566-tmsocyfc	275	8	nerve	nerve	NN
cord-290566-tmsocyfc	275	9	growth	growth	NN
cord-290566-tmsocyfc	275	10	factors	factor	NNS
cord-290566-tmsocyfc	275	11	,	,	,
cord-290566-tmsocyfc	275	12	including	include	VBG
cord-290566-tmsocyfc	275	13	brain	brain	NN
cord-290566-tmsocyfc	275	14	-	-	HYPH
cord-290566-tmsocyfc	275	15	derived	derive	VBN
cord-290566-tmsocyfc	275	16	neurotrophic	neurotrophic	NN
cord-290566-tmsocyfc	275	17	factor	factor	NN
cord-290566-tmsocyfc	275	18	(	(	-LRB-
cord-290566-tmsocyfc	275	19	BDNF	BDNF	NNP
cord-290566-tmsocyfc	275	20	)	)	-RRB-
cord-290566-tmsocyfc	275	21	,	,	,
cord-290566-tmsocyfc	275	22	was	be	VBD
cord-290566-tmsocyfc	275	23	upregulated	upregulate	VBN
cord-290566-tmsocyfc	275	24	after	after	IN
cord-290566-tmsocyfc	275	25	antigen	antigen	NN
cord-290566-tmsocyfc	275	26	-	-	HYPH
cord-290566-tmsocyfc	275	27	activation	activation	NN
cord-290566-tmsocyfc	275	28	of	of	IN
cord-290566-tmsocyfc	275	29	these	these	DT
cord-290566-tmsocyfc	275	30	T	t	NN
cord-290566-tmsocyfc	275	31	cells	cell	NNS
cord-290566-tmsocyfc	275	32	,	,	,
cord-290566-tmsocyfc	275	33	while	while	IN
cord-290566-tmsocyfc	275	34	the	the	DT
cord-290566-tmsocyfc	275	35	injured	injure	VBN
cord-290566-tmsocyfc	275	36	nerve	nerve	NN
cord-290566-tmsocyfc	275	37	expressed	express	VBD
cord-290566-tmsocyfc	275	38	mRNA	mrna	NN
cord-290566-tmsocyfc	275	39	for	for	IN
cord-290566-tmsocyfc	275	40	nerve	nerve	NN
cord-290566-tmsocyfc	275	41	growth	growth	NN
cord-290566-tmsocyfc	275	42	factor	factor	NN
cord-290566-tmsocyfc	275	43	receptors	receptor	NNS
cord-290566-tmsocyfc	275	44	(	(	-LRB-
cord-290566-tmsocyfc	275	45	Moalem	Moalem	NNP
cord-290566-tmsocyfc	275	46	et	et	NNP
cord-290566-tmsocyfc	275	47	al	al	NNP
cord-290566-tmsocyfc	275	48	.	.	NNP
cord-290566-tmsocyfc	275	49	,	,	,
cord-290566-tmsocyfc	275	50	2000	2000	CD
cord-290566-tmsocyfc	275	51	)	)	-RRB-
cord-290566-tmsocyfc	275	52	.	.	.
cord-290566-tmsocyfc	276	1	Two	two	CD
cord-290566-tmsocyfc	276	2	major	major	JJ
cord-290566-tmsocyfc	276	3	types	type	NNS
cord-290566-tmsocyfc	276	4	of	of	IN
cord-290566-tmsocyfc	276	5	Th	Th	NNP
cord-290566-tmsocyfc	276	6	cell	cell	NN
cord-290566-tmsocyfc	276	7	responses	response	NNS
cord-290566-tmsocyfc	276	8	have	have	VBP
cord-290566-tmsocyfc	276	9	been	be	VBN
cord-290566-tmsocyfc	276	10	described	describe	VBN
cord-290566-tmsocyfc	276	11	,	,	,
cord-290566-tmsocyfc	276	12	based	base	VBN
cord-290566-tmsocyfc	276	13	on	on	IN
cord-290566-tmsocyfc	276	14	cytokine	cytokine	JJ
cord-290566-tmsocyfc	276	15	secretion	secretion	NN
cord-290566-tmsocyfc	276	16	.	.	.
cord-290566-tmsocyfc	277	1	Th1	th1	NN
cord-290566-tmsocyfc	277	2	cells	cell	NNS
cord-290566-tmsocyfc	277	3	produce	produce	VBP
cord-290566-tmsocyfc	277	4	the	the	DT
cord-290566-tmsocyfc	277	5	cytokines	cytokine	NNS
cord-290566-tmsocyfc	277	6	IFN	IFN	NNP
cord-290566-tmsocyfc	277	7	-	-	:
cord-290566-tmsocyfc	277	8	and	and	CC
cord-290566-tmsocyfc	277	9	TNF-	TNF-	NNP
cord-290566-tmsocyfc	277	10	,	,	,
cord-290566-tmsocyfc	277	11	while	while	IN
cord-290566-tmsocyfc	277	12	Th2	th2	CD
cord-290566-tmsocyfc	277	13	cells	cell	NNS
cord-290566-tmsocyfc	277	14	produce	produce	VBP
cord-290566-tmsocyfc	277	15	IL-4	IL-4	NNP
cord-290566-tmsocyfc	277	16	,	,	,
cord-290566-tmsocyfc	277	17	IL-5	IL-5	NNP
cord-290566-tmsocyfc	277	18	,	,	,
cord-290566-tmsocyfc	277	19	and	and	CC
cord-290566-tmsocyfc	277	20	IL-10	IL-10	NNP
cord-290566-tmsocyfc	277	21	.	.	.
cord-290566-tmsocyfc	278	1	EAE	EAE	NNP
cord-290566-tmsocyfc	278	2	has	have	VBZ
cord-290566-tmsocyfc	278	3	been	be	VBN
cord-290566-tmsocyfc	278	4	associated	associate	VBN
cord-290566-tmsocyfc	278	5	with	with	IN
cord-290566-tmsocyfc	278	6	a	a	DT
cord-290566-tmsocyfc	278	7	Th1	th1	CD
cord-290566-tmsocyfc	278	8	response	response	NN
cord-290566-tmsocyfc	278	9	,	,	,
cord-290566-tmsocyfc	278	10	while	while	IN
cord-290566-tmsocyfc	278	11	Th2	th2	CD
cord-290566-tmsocyfc	278	12	cytokines	cytokine	NNS
cord-290566-tmsocyfc	278	13	are	be	VBP
cord-290566-tmsocyfc	278	14	generally	generally	RB
cord-290566-tmsocyfc	278	15	protective	protective	JJ
cord-290566-tmsocyfc	278	16	.	.	.
cord-290566-tmsocyfc	279	1	In	in	IN
cord-290566-tmsocyfc	279	2	support	support	NN
cord-290566-tmsocyfc	279	3	of	of	IN
cord-290566-tmsocyfc	279	4	the	the	DT
cord-290566-tmsocyfc	279	5	above	above	JJ
cord-290566-tmsocyfc	279	6	findings	finding	NNS
cord-290566-tmsocyfc	279	7	,	,	,
cord-290566-tmsocyfc	279	8	a	a	DT
cord-290566-tmsocyfc	279	9	separate	separate	JJ
cord-290566-tmsocyfc	279	10	study	study	NN
cord-290566-tmsocyfc	279	11	demonstrated	demonstrate	VBD
cord-290566-tmsocyfc	279	12	that	that	IN
cord-290566-tmsocyfc	279	13	the	the	DT
cord-290566-tmsocyfc	279	14	presence	presence	NN
cord-290566-tmsocyfc	279	15	of	of	IN
cord-290566-tmsocyfc	279	16	myelin	myelin	NN
cord-290566-tmsocyfc	279	17	-	-	HYPH
cord-290566-tmsocyfc	279	18	reactive	reactive	JJ
cord-290566-tmsocyfc	279	19	Th2	th2	CD
cord-290566-tmsocyfc	279	20	cells	cell	NNS
cord-290566-tmsocyfc	279	21	conferred	confer	VBD
cord-290566-tmsocyfc	279	22	neuroprotection	neuroprotection	NN
cord-290566-tmsocyfc	279	23	in	in	IN
cord-290566-tmsocyfc	279	24	organotypic	organotypic	JJ
cord-290566-tmsocyfc	279	25	hippocampal	hippocampal	JJ
cord-290566-tmsocyfc	279	26	slice	slice	NN
cord-290566-tmsocyfc	279	27	cultures	culture	NNS
cord-290566-tmsocyfc	280	1	(	(	-LRB-
cord-290566-tmsocyfc	280	2	Wolf	Wolf	NNP
cord-290566-tmsocyfc	280	3	et	et	NNP
cord-290566-tmsocyfc	280	4	al	al	NNP
cord-290566-tmsocyfc	280	5	.	.	NNP
cord-290566-tmsocyfc	280	6	,	,	,
cord-290566-tmsocyfc	280	7	2002	2002	CD
cord-290566-tmsocyfc	280	8	)	)	-RRB-
cord-290566-tmsocyfc	280	9	.	.	.
cord-290566-tmsocyfc	281	1	These	these	DT
cord-290566-tmsocyfc	281	2	findings	finding	NNS
cord-290566-tmsocyfc	281	3	have	have	VBP
cord-290566-tmsocyfc	281	4	several	several	JJ
cord-290566-tmsocyfc	281	5	implications	implication	NNS
cord-290566-tmsocyfc	281	6	for	for	IN
cord-290566-tmsocyfc	281	7	MS	MS	NNP
cord-290566-tmsocyfc	281	8	.	.	.
cord-290566-tmsocyfc	282	1	First	first	RB
cord-290566-tmsocyfc	282	2	,	,	,
cord-290566-tmsocyfc	282	3	myelinreactive	myelinreactive	NNP
cord-290566-tmsocyfc	282	4	T	t	NN
cord-290566-tmsocyfc	282	5	cells	cell	NNS
cord-290566-tmsocyfc	282	6	may	may	MD
cord-290566-tmsocyfc	282	7	be	be	VB
cord-290566-tmsocyfc	282	8	neuroprotective	neuroprotective	JJ
cord-290566-tmsocyfc	282	9	under	under	IN
cord-290566-tmsocyfc	282	10	certain	certain	JJ
cord-290566-tmsocyfc	282	11	conditions	condition	NNS
cord-290566-tmsocyfc	282	12	including	include	VBG
cord-290566-tmsocyfc	282	13	trauma	trauma	NN
cord-290566-tmsocyfc	282	14	,	,	,
cord-290566-tmsocyfc	282	15	suggesting	suggest	VBG
cord-290566-tmsocyfc	282	16	that	that	IN
cord-290566-tmsocyfc	282	17	the	the	DT
cord-290566-tmsocyfc	282	18	MS	MS	NNP
cord-290566-tmsocyfc	282	19	brain	brain	NN
cord-290566-tmsocyfc	282	20	may	may	MD
cord-290566-tmsocyfc	282	21	be	be	VB
cord-290566-tmsocyfc	282	22	more	more	RBR
cord-290566-tmsocyfc	282	23	susceptible	susceptible	JJ
cord-290566-tmsocyfc	282	24	to	to	IN
cord-290566-tmsocyfc	282	25	inflammationinduced	inflammationinduced	JJ
cord-290566-tmsocyfc	282	26	damage	damage	NN
cord-290566-tmsocyfc	282	27	.	.	.
cord-290566-tmsocyfc	283	1	Second	second	RB
cord-290566-tmsocyfc	283	2	,	,	,
cord-290566-tmsocyfc	283	3	the	the	DT
cord-290566-tmsocyfc	283	4	local	local	JJ
cord-290566-tmsocyfc	283	5	production	production	NN
cord-290566-tmsocyfc	283	6	of	of	IN
cord-290566-tmsocyfc	283	7	neurotrophic	neurotrophic	NN
cord-290566-tmsocyfc	283	8	factors	factor	NNS
cord-290566-tmsocyfc	283	9	by	by	IN
cord-290566-tmsocyfc	283	10	inflammatory	inflammatory	JJ
cord-290566-tmsocyfc	283	11	cells	cell	NNS
cord-290566-tmsocyfc	283	12	may	may	MD
cord-290566-tmsocyfc	283	13	be	be	VB
cord-290566-tmsocyfc	283	14	neuroprotective	neuroprotective	JJ
cord-290566-tmsocyfc	283	15	.	.	.
cord-290566-tmsocyfc	284	1	However	however	RB
cord-290566-tmsocyfc	284	2	,	,	,
cord-290566-tmsocyfc	284	3	in	in	IN
cord-290566-tmsocyfc	284	4	contrast	contrast	NN
cord-290566-tmsocyfc	284	5	to	to	IN
cord-290566-tmsocyfc	284	6	these	these	DT
cord-290566-tmsocyfc	284	7	findings	finding	NNS
cord-290566-tmsocyfc	284	8	,	,	,
cord-290566-tmsocyfc	284	9	other	other	JJ
cord-290566-tmsocyfc	284	10	studies	study	NNS
cord-290566-tmsocyfc	284	11	have	have	VBP
cord-290566-tmsocyfc	284	12	shown	show	VBN
cord-290566-tmsocyfc	284	13	that	that	IN
cord-290566-tmsocyfc	284	14	MBP	MBP	NNP
cord-290566-tmsocyfc	284	15	-	-	HYPH
cord-290566-tmsocyfc	284	16	TCR	TCR	NNP
cord-290566-tmsocyfc	284	17	transgenic	transgenic	JJ
cord-290566-tmsocyfc	284	18	mice	mouse	NNS
cord-290566-tmsocyfc	284	19	sustained	sustain	VBD
cord-290566-tmsocyfc	284	20	more	more	JJR
cord-290566-tmsocyfc	284	21	CNS	CNS	NNP
cord-290566-tmsocyfc	284	22	damage	damage	NN
cord-290566-tmsocyfc	284	23	and	and	CC
cord-290566-tmsocyfc	284	24	inflammation	inflammation	NN
cord-290566-tmsocyfc	284	25	following	follow	VBG
cord-290566-tmsocyfc	284	26	traumatic	traumatic	JJ
cord-290566-tmsocyfc	284	27	spinal	spinal	JJ
cord-290566-tmsocyfc	284	28	cord	cord	NN
cord-290566-tmsocyfc	284	29	injury	injury	NN
cord-290566-tmsocyfc	284	30	,	,	,
cord-290566-tmsocyfc	284	31	compared	compare	VBN
cord-290566-tmsocyfc	284	32	with	with	IN
cord-290566-tmsocyfc	284	33	wildtype	wildtype	JJ
cord-290566-tmsocyfc	284	34	controls	control	NNS
cord-290566-tmsocyfc	284	35	(	(	-LRB-
cord-290566-tmsocyfc	284	36	Jones	Jones	NNP
cord-290566-tmsocyfc	284	37	et	et	NNP
cord-290566-tmsocyfc	284	38	al	al	NNP
cord-290566-tmsocyfc	284	39	.	.	NNP
cord-290566-tmsocyfc	284	40	,	,	,
cord-290566-tmsocyfc	284	41	2002	2002	CD
cord-290566-tmsocyfc	284	42	)	)	-RRB-
cord-290566-tmsocyfc	284	43	.	.	.
cord-290566-tmsocyfc	285	1	T	t	NN
cord-290566-tmsocyfc	285	2	-	-	HYPH
cord-290566-tmsocyfc	285	3	cell	cell	NN
cord-290566-tmsocyfc	285	4	infiltrates	infiltrate	NNS
cord-290566-tmsocyfc	285	5	were	be	VBD
cord-290566-tmsocyfc	285	6	localized	localize	VBN
cord-290566-tmsocyfc	285	7	to	to	IN
cord-290566-tmsocyfc	285	8	areas	area	NNS
cord-290566-tmsocyfc	285	9	of	of	IN
cord-290566-tmsocyfc	285	10	demyelination	demyelination	NN
cord-290566-tmsocyfc	285	11	and	and	CC
cord-290566-tmsocyfc	285	12	axonal	axonal	JJ
cord-290566-tmsocyfc	285	13	loss	loss	NN
cord-290566-tmsocyfc	285	14	,	,	,
cord-290566-tmsocyfc	285	15	suggesting	suggest	VBG
cord-290566-tmsocyfc	285	16	that	that	IN
cord-290566-tmsocyfc	285	17	autoreactive	autoreactive	JJ
cord-290566-tmsocyfc	285	18	T	t	NN
cord-290566-tmsocyfc	285	19	cells	cell	NNS
cord-290566-tmsocyfc	285	20	can	can	MD
cord-290566-tmsocyfc	285	21	trigger	trigger	VB
cord-290566-tmsocyfc	285	22	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	285	23	demyelination	demyelination	NN
cord-290566-tmsocyfc	285	24	in	in	IN
cord-290566-tmsocyfc	285	25	the	the	DT
cord-290566-tmsocyfc	285	26	setting	setting	NN
cord-290566-tmsocyfc	285	27	of	of	IN
cord-290566-tmsocyfc	285	28	trauma	trauma	NN
cord-290566-tmsocyfc	285	29	under	under	IN
cord-290566-tmsocyfc	285	30	certain	certain	JJ
cord-290566-tmsocyfc	285	31	circumstances	circumstance	NNS
cord-290566-tmsocyfc	285	32	.	.	.
cord-290566-tmsocyfc	286	1	Therefore	therefore	RB
cord-290566-tmsocyfc	286	2	,	,	,
cord-290566-tmsocyfc	286	3	the	the	DT
cord-290566-tmsocyfc	286	4	therapeutic	therapeutic	JJ
cord-290566-tmsocyfc	286	5	potential	potential	NN
cord-290566-tmsocyfc	286	6	of	of	IN
cord-290566-tmsocyfc	286	7	neuroprotective	neuroprotective	JJ
cord-290566-tmsocyfc	286	8	T	t	NN
cord-290566-tmsocyfc	286	9	lymphocytes	lymphocyte	NNS
cord-290566-tmsocyfc	286	10	should	should	MD
cord-290566-tmsocyfc	286	11	be	be	VB
cord-290566-tmsocyfc	286	12	entertained	entertain	VBN
cord-290566-tmsocyfc	286	13	only	only	RB
cord-290566-tmsocyfc	286	14	with	with	IN
cord-290566-tmsocyfc	286	15	caution	caution	NN
cord-290566-tmsocyfc	286	16	.	.	.
cord-290566-tmsocyfc	287	1	Glatiramer	glatiramer	JJ
cord-290566-tmsocyfc	287	2	acetate	acetate	NN
cord-290566-tmsocyfc	287	3	(	(	-LRB-
cord-290566-tmsocyfc	287	4	GA	GA	NNP
cord-290566-tmsocyfc	287	5	)	)	-RRB-
cord-290566-tmsocyfc	287	6	is	be	VBZ
cord-290566-tmsocyfc	287	7	an	an	DT
cord-290566-tmsocyfc	287	8	established	establish	VBN
cord-290566-tmsocyfc	287	9	treatment	treatment	NN
cord-290566-tmsocyfc	287	10	for	for	IN
cord-290566-tmsocyfc	287	11	RRMS	RRMS	NNP
cord-290566-tmsocyfc	287	12	.	.	.
cord-290566-tmsocyfc	288	1	Its	-PRON-	PRP$
cord-290566-tmsocyfc	288	2	mechanism	mechanism	NN
cord-290566-tmsocyfc	288	3	of	of	IN
cord-290566-tmsocyfc	288	4	action	action	NN
cord-290566-tmsocyfc	288	5	relies	rely	VBZ
cord-290566-tmsocyfc	288	6	,	,	,
cord-290566-tmsocyfc	288	7	in	in	IN
cord-290566-tmsocyfc	288	8	part	part	NN
cord-290566-tmsocyfc	288	9	,	,	,
cord-290566-tmsocyfc	288	10	on	on	IN
cord-290566-tmsocyfc	288	11	the	the	DT
cord-290566-tmsocyfc	288	12	migration	migration	NN
cord-290566-tmsocyfc	288	13	of	of	IN
cord-290566-tmsocyfc	288	14	Th2	th2	CD
cord-290566-tmsocyfc	288	15	cells	cell	NNS
cord-290566-tmsocyfc	288	16	into	into	IN
cord-290566-tmsocyfc	288	17	the	the	DT
cord-290566-tmsocyfc	288	18	CNS	CNS	NNP
cord-290566-tmsocyfc	288	19	(	(	-LRB-
cord-290566-tmsocyfc	288	20	Aharoni	Aharoni	NNP
cord-290566-tmsocyfc	288	21	et	et	FW
cord-290566-tmsocyfc	288	22	al	al	NNP
cord-290566-tmsocyfc	288	23	.	.	NNP
cord-290566-tmsocyfc	288	24	,	,	,
cord-290566-tmsocyfc	288	25	2000	2000	CD
cord-290566-tmsocyfc	289	1	(	(	-LRB-
cord-290566-tmsocyfc	289	2	Aharoni	Aharoni	NNP
cord-290566-tmsocyfc	289	3	et	et	FW
cord-290566-tmsocyfc	289	4	al	al	NNP
cord-290566-tmsocyfc	289	5	.	.	NNP
cord-290566-tmsocyfc	289	6	,	,	,
cord-290566-tmsocyfc	289	7	,	,	,
cord-290566-tmsocyfc	289	8	2002	2002	CD
cord-290566-tmsocyfc	289	9	,	,	,
cord-290566-tmsocyfc	289	10	where	where	WRB
cord-290566-tmsocyfc	289	11	they	-PRON-	PRP
cord-290566-tmsocyfc	289	12	presumably	presumably	RB
cord-290566-tmsocyfc	289	13	downregulate	downregulate	VBP
cord-290566-tmsocyfc	289	14	local	local	JJ
cord-290566-tmsocyfc	289	15	inflammatory	inflammatory	JJ
cord-290566-tmsocyfc	289	16	responses	response	NNS
cord-290566-tmsocyfc	289	17	.	.	.
cord-290566-tmsocyfc	290	1	Interestingly	interestingly	RB
cord-290566-tmsocyfc	290	2	,	,	,
cord-290566-tmsocyfc	290	3	these	these	DT
cord-290566-tmsocyfc	290	4	T	t	NN
cord-290566-tmsocyfc	290	5	cells	cell	NNS
cord-290566-tmsocyfc	290	6	have	have	VBP
cord-290566-tmsocyfc	290	7	been	be	VBN
cord-290566-tmsocyfc	290	8	shown	show	VBN
cord-290566-tmsocyfc	290	9	to	to	TO
cord-290566-tmsocyfc	290	10	produce	produce	VB
cord-290566-tmsocyfc	290	11	BDNF	BDNF	NNP
cord-290566-tmsocyfc	290	12	in	in	IN
cord-290566-tmsocyfc	290	13	the	the	DT
cord-290566-tmsocyfc	290	14	EAE	EAE	NNP
cord-290566-tmsocyfc	290	15	model	model	NN
cord-290566-tmsocyfc	291	1	(	(	-LRB-
cord-290566-tmsocyfc	291	2	Aharoni	Aharoni	NNP
cord-290566-tmsocyfc	291	3	et	et	FW
cord-290566-tmsocyfc	291	4	al	al	NNP
cord-290566-tmsocyfc	291	5	.	.	NNP
cord-290566-tmsocyfc	291	6	,	,	,
cord-290566-tmsocyfc	291	7	2003	2003	CD
cord-290566-tmsocyfc	291	8	)	)	-RRB-
cord-290566-tmsocyfc	291	9	,	,	,
cord-290566-tmsocyfc	291	10	and	and	CC
cord-290566-tmsocyfc	291	11	GA	GA	NNP
cord-290566-tmsocyfc	291	12	-	-	HYPH
cord-290566-tmsocyfc	291	13	reactive	reactive	JJ
cord-290566-tmsocyfc	291	14	T	T	NNP
cord-290566-tmsocyfc	291	15	cells	cell	NNS
cord-290566-tmsocyfc	291	16	harvested	harvest	VBN
cord-290566-tmsocyfc	291	17	from	from	IN
cord-290566-tmsocyfc	291	18	MS	MS	NNP
cord-290566-tmsocyfc	291	19	patients	patient	NNS
cord-290566-tmsocyfc	291	20	treated	treat	VBN
cord-290566-tmsocyfc	291	21	with	with	IN
cord-290566-tmsocyfc	291	22	GA	GA	NNP
cord-290566-tmsocyfc	291	23	produce	produce	VB
cord-290566-tmsocyfc	291	24	BDNF	BDNF	NNP
cord-290566-tmsocyfc	291	25	on	on	IN
cord-290566-tmsocyfc	291	26	restimulation	restimulation	NN
cord-290566-tmsocyfc	292	1	in	in	IN
cord-290566-tmsocyfc	292	2	vitro	vitro	FW
cord-290566-tmsocyfc	293	1	(	(	-LRB-
cord-290566-tmsocyfc	293	2	Ziemssen	Ziemssen	NNP
cord-290566-tmsocyfc	293	3	et	et	NNP
cord-290566-tmsocyfc	293	4	al	al	NNP
cord-290566-tmsocyfc	293	5	.	.	NNP
cord-290566-tmsocyfc	293	6	,	,	,
cord-290566-tmsocyfc	293	7	2002	2002	CD
cord-290566-tmsocyfc	293	8	)	)	-RRB-
cord-290566-tmsocyfc	293	9	.	.	.
cord-290566-tmsocyfc	294	1	However	however	RB
cord-290566-tmsocyfc	294	2	,	,	,
cord-290566-tmsocyfc	294	3	the	the	DT
cord-290566-tmsocyfc	294	4	role	role	NN
cord-290566-tmsocyfc	294	5	of	of	IN
cord-290566-tmsocyfc	294	6	BDNF	BDNF	NNP
cord-290566-tmsocyfc	294	7	in	in	IN
cord-290566-tmsocyfc	294	8	neuroprotection	neuroprotection	NN
cord-290566-tmsocyfc	294	9	in	in	IN
cord-290566-tmsocyfc	294	10	MS	MS	NNP
cord-290566-tmsocyfc	294	11	or	or	CC
cord-290566-tmsocyfc	294	12	EAE	EAE	NNP
cord-290566-tmsocyfc	294	13	has	have	VBZ
cord-290566-tmsocyfc	294	14	not	not	RB
cord-290566-tmsocyfc	294	15	been	be	VBN
cord-290566-tmsocyfc	294	16	established	establish	VBN
cord-290566-tmsocyfc	294	17	.	.	.
cord-290566-tmsocyfc	295	1	Thus	thus	RB
cord-290566-tmsocyfc	295	2	,	,	,
cord-290566-tmsocyfc	295	3	the	the	DT
cord-290566-tmsocyfc	295	4	role	role	NN
cord-290566-tmsocyfc	295	5	of	of	IN
cord-290566-tmsocyfc	295	6	this	this	DT
cord-290566-tmsocyfc	295	7	and	and	CC
cord-290566-tmsocyfc	295	8	other	other	JJ
cord-290566-tmsocyfc	295	9	neurotrophic	neurotrophic	NN
cord-290566-tmsocyfc	295	10	factors	factor	NNS
cord-290566-tmsocyfc	295	11	requires	require	VBZ
cord-290566-tmsocyfc	295	12	further	further	JJ
cord-290566-tmsocyfc	295	13	exploration	exploration	NN
cord-290566-tmsocyfc	295	14	.	.	.
cord-290566-tmsocyfc	296	1	The	the	DT
cord-290566-tmsocyfc	296	2	success	success	NN
cord-290566-tmsocyfc	296	3	of	of	IN
cord-290566-tmsocyfc	296	4	several	several	JJ
cord-290566-tmsocyfc	296	5	T	T	NNP
cord-290566-tmsocyfc	296	6	cell	cell	NN
cord-290566-tmsocyfc	296	7	-	-	HYPH
cord-290566-tmsocyfc	296	8	targeted	target	VBN
cord-290566-tmsocyfc	296	9	therapies	therapy	NNS
cord-290566-tmsocyfc	296	10	in	in	IN
cord-290566-tmsocyfc	296	11	MS	MS	NNP
cord-290566-tmsocyfc	296	12	reinforces	reinforce	VBZ
cord-290566-tmsocyfc	296	13	the	the	DT
cord-290566-tmsocyfc	296	14	importance	importance	NN
cord-290566-tmsocyfc	296	15	of	of	IN
cord-290566-tmsocyfc	296	16	the	the	DT
cord-290566-tmsocyfc	296	17	role	role	NN
cord-290566-tmsocyfc	296	18	of	of	IN
cord-290566-tmsocyfc	296	19	the	the	DT
cord-290566-tmsocyfc	296	20	T	T	NNP
cord-290566-tmsocyfc	296	21	cell	cell	NN
cord-290566-tmsocyfc	296	22	in	in	IN
cord-290566-tmsocyfc	296	23	MS	MS	NNP
cord-290566-tmsocyfc	296	24	pathogenesis	pathogenesis	NN
cord-290566-tmsocyfc	296	25	.	.	.
cord-290566-tmsocyfc	297	1	Of	of	IN
cord-290566-tmsocyfc	297	2	the	the	DT
cord-290566-tmsocyfc	297	3	six	six	CD
cord-290566-tmsocyfc	297	4	approved	approve	VBN
cord-290566-tmsocyfc	297	5	therapies	therapy	NNS
cord-290566-tmsocyfc	297	6	for	for	IN
cord-290566-tmsocyfc	297	7	MS	MS	NNP
cord-290566-tmsocyfc	297	8	,	,	,
cord-290566-tmsocyfc	297	9	the	the	DT
cord-290566-tmsocyfc	297	10	eVects	evect	NNS
cord-290566-tmsocyfc	297	11	of	of	IN
cord-290566-tmsocyfc	297	12	GA	GA	NNP
cord-290566-tmsocyfc	297	13	and	and	CC
cord-290566-tmsocyfc	297	14	natalizumab	natalizumab	NNS
cord-290566-tmsocyfc	297	15	can	can	MD
cord-290566-tmsocyfc	297	16	be	be	VB
cord-290566-tmsocyfc	297	17	directly	directly	RB
cord-290566-tmsocyfc	297	18	related	relate	VBN
cord-290566-tmsocyfc	297	19	to	to	IN
cord-290566-tmsocyfc	297	20	modulation	modulation	NN
cord-290566-tmsocyfc	297	21	58	58	CD
cord-290566-tmsocyfc	297	22	TANUJA	TANUJA	NNP
cord-290566-tmsocyfc	297	23	CHITNIS	CHITNIS	NNP
cord-290566-tmsocyfc	297	24	of	of	IN
cord-290566-tmsocyfc	297	25	T	t	NN
cord-290566-tmsocyfc	297	26	-	-	HYPH
cord-290566-tmsocyfc	297	27	cell	cell	NN
cord-290566-tmsocyfc	297	28	function	function	NN
cord-290566-tmsocyfc	297	29	.	.	.
cord-290566-tmsocyfc	298	1	modulate	modulate	VB
cord-290566-tmsocyfc	298	2	some	some	DT
cord-290566-tmsocyfc	298	3	T	t	NN
cord-290566-tmsocyfc	298	4	-	-	HYPH
cord-290566-tmsocyfc	298	5	cell	cell	NN
cord-290566-tmsocyfc	298	6	functions	function	NNS
cord-290566-tmsocyfc	298	7	including	include	VBG
cord-290566-tmsocyfc	298	8	T	t	NN
cord-290566-tmsocyfc	298	9	-	-	HYPH
cord-290566-tmsocyfc	298	10	cell	cell	NN
cord-290566-tmsocyfc	298	11	migration	migration	NN
cord-290566-tmsocyfc	298	12	and	and	CC
cord-290566-tmsocyfc	298	13	Th1	th1	NN
cord-290566-tmsocyfc	298	14	cytokine	cytokine	NN
cord-290566-tmsocyfc	298	15	production	production	NN
cord-290566-tmsocyfc	298	16	(	(	-LRB-
cord-290566-tmsocyfc	298	17	Yong	Yong	NNP
cord-290566-tmsocyfc	298	18	,	,	,
cord-290566-tmsocyfc	298	19	2002	2002	CD
cord-290566-tmsocyfc	298	20	)	)	-RRB-
cord-290566-tmsocyfc	298	21	,	,	,
cord-290566-tmsocyfc	298	22	while	while	IN
cord-290566-tmsocyfc	298	23	mitoxantrone	mitoxantrone	NN
cord-290566-tmsocyfc	298	24	is	be	VBZ
cord-290566-tmsocyfc	298	25	a	a	DT
cord-290566-tmsocyfc	298	26	cytotoxic	cytotoxic	JJ
cord-290566-tmsocyfc	298	27	agent	agent	NN
cord-290566-tmsocyfc	298	28	that	that	WDT
cord-290566-tmsocyfc	298	29	nonspecifically	nonspecifically	RB
cord-290566-tmsocyfc	298	30	abrogates	abrogate	VBZ
cord-290566-tmsocyfc	298	31	T	T	NNP
cord-290566-tmsocyfc	298	32	-	-	HYPH
cord-290566-tmsocyfc	298	33	and	and	CC
cord-290566-tmsocyfc	298	34	B	b	NN
cord-290566-tmsocyfc	298	35	-	-	HYPH
cord-290566-tmsocyfc	298	36	cell	cell	NN
cord-290566-tmsocyfc	298	37	proliferation	proliferation	NN
cord-290566-tmsocyfc	298	38	.	.	.
cord-290566-tmsocyfc	299	1	An	an	DT
cord-290566-tmsocyfc	299	2	altered	altered	JJ
cord-290566-tmsocyfc	299	3	peptide	peptide	NN
cord-290566-tmsocyfc	299	4	ligand	ligand	NN
cord-290566-tmsocyfc	299	5	(	(	-LRB-
cord-290566-tmsocyfc	299	6	APL	APL	NNP
cord-290566-tmsocyfc	299	7	)	)	-RRB-
cord-290566-tmsocyfc	299	8	may	may	MD
cord-290566-tmsocyfc	299	9	be	be	VB
cord-290566-tmsocyfc	299	10	defined	define	VBN
cord-290566-tmsocyfc	299	11	as	as	IN
cord-290566-tmsocyfc	299	12	'	'	''
cord-290566-tmsocyfc	299	13	'	'	''
cord-290566-tmsocyfc	299	14	any	any	DT
cord-290566-tmsocyfc	299	15	peptide	peptide	NN
cord-290566-tmsocyfc	299	16	that	that	WDT
cord-290566-tmsocyfc	299	17	serves	serve	VBZ
cord-290566-tmsocyfc	299	18	as	as	IN
cord-290566-tmsocyfc	299	19	a	a	DT
cord-290566-tmsocyfc	299	20	receptor	receptor	NN
cord-290566-tmsocyfc	299	21	ligand	ligand	NN
cord-290566-tmsocyfc	299	22	in	in	IN
cord-290566-tmsocyfc	299	23	which	which	WDT
cord-290566-tmsocyfc	299	24	substitutions	substitution	NNS
cord-290566-tmsocyfc	299	25	of	of	IN
cord-290566-tmsocyfc	299	26	a	a	DT
cord-290566-tmsocyfc	299	27	single	single	JJ
cord-290566-tmsocyfc	299	28	or	or	CC
cord-290566-tmsocyfc	299	29	multiple	multiple	JJ
cord-290566-tmsocyfc	299	30	amino	amino	NN
cord-290566-tmsocyfc	299	31	acids	acid	NNS
cord-290566-tmsocyfc	299	32	lead	lead	VBP
cord-290566-tmsocyfc	299	33	to	to	IN
cord-290566-tmsocyfc	299	34	changes	change	NNS
cord-290566-tmsocyfc	299	35	in	in	IN
cord-290566-tmsocyfc	299	36	the	the	DT
cord-290566-tmsocyfc	299	37	functional	functional	JJ
cord-290566-tmsocyfc	299	38	outcome	outcome	NN
cord-290566-tmsocyfc	299	39	of	of	IN
cord-290566-tmsocyfc	299	40	receptor	receptor	NN
cord-290566-tmsocyfc	299	41	signaling	signaling	NN
cord-290566-tmsocyfc	299	42	'	'	''
cord-290566-tmsocyfc	299	43	'	'	''
cord-290566-tmsocyfc	300	1	(	(	-LRB-
cord-290566-tmsocyfc	300	2	Bielekova	Bielekova	NNP
cord-290566-tmsocyfc	300	3	and	and	CC
cord-290566-tmsocyfc	300	4	Martin	Martin	NNP
cord-290566-tmsocyfc	300	5	,	,	,
cord-290566-tmsocyfc	300	6	2001	2001	CD
cord-290566-tmsocyfc	300	7	)	)	-RRB-
cord-290566-tmsocyfc	300	8	.	.	.
cord-290566-tmsocyfc	301	1	APLs	apl	NNS
cord-290566-tmsocyfc	301	2	have	have	VBP
cord-290566-tmsocyfc	301	3	most	most	RBS
cord-290566-tmsocyfc	301	4	commonly	commonly	RB
cord-290566-tmsocyfc	301	5	been	be	VBN
cord-290566-tmsocyfc	301	6	used	use	VBN
cord-290566-tmsocyfc	301	7	as	as	IN
cord-290566-tmsocyfc	301	8	TCR	TCR	NNP
cord-290566-tmsocyfc	301	9	ligands	ligand	NNS
cord-290566-tmsocyfc	301	10	to	to	TO
cord-290566-tmsocyfc	301	11	alter	alter	VB
cord-290566-tmsocyfc	301	12	T	t	NN
cord-290566-tmsocyfc	301	13	-	-	HYPH
cord-290566-tmsocyfc	301	14	cell	cell	NN
cord-290566-tmsocyfc	301	15	responses	response	NNS
cord-290566-tmsocyfc	301	16	to	to	IN
cord-290566-tmsocyfc	301	17	presumed	presume	VBN
cord-290566-tmsocyfc	301	18	immunogenic	immunogenic	JJ
cord-290566-tmsocyfc	301	19	or	or	CC
cord-290566-tmsocyfc	301	20	target	target	NN
cord-290566-tmsocyfc	301	21	antigens	antigen	NNS
cord-290566-tmsocyfc	301	22	presumably	presumably	RB
cord-290566-tmsocyfc	301	23	resulting	result	VBG
cord-290566-tmsocyfc	301	24	in	in	IN
cord-290566-tmsocyfc	301	25	immune	immune	JJ
cord-290566-tmsocyfc	301	26	suppression	suppression	NN
cord-290566-tmsocyfc	301	27	or	or	CC
cord-290566-tmsocyfc	301	28	immune	immune	JJ
cord-290566-tmsocyfc	301	29	deviation	deviation	NN
cord-290566-tmsocyfc	301	30	as	as	RB
cord-290566-tmsocyfc	301	31	well	well	RB
cord-290566-tmsocyfc	301	32	as	as	IN
cord-290566-tmsocyfc	301	33	induction	induction	NN
cord-290566-tmsocyfc	301	34	of	of	IN
cord-290566-tmsocyfc	301	35	a	a	DT
cord-290566-tmsocyfc	301	36	regulatory	regulatory	JJ
cord-290566-tmsocyfc	301	37	T	t	NN
cord-290566-tmsocyfc	301	38	-	-	HYPH
cord-290566-tmsocyfc	301	39	cell	cell	NN
cord-290566-tmsocyfc	301	40	population	population	NN
cord-290566-tmsocyfc	301	41	reactive	reactive	JJ
cord-290566-tmsocyfc	301	42	to	to	IN
cord-290566-tmsocyfc	301	43	the	the	DT
cord-290566-tmsocyfc	301	44	APL	APL	NNP
cord-290566-tmsocyfc	301	45	itself	-PRON-	PRP
cord-290566-tmsocyfc	301	46	,	,	,
cord-290566-tmsocyfc	301	47	which	which	WDT
cord-290566-tmsocyfc	301	48	then	then	RB
cord-290566-tmsocyfc	301	49	serves	serve	VBZ
cord-290566-tmsocyfc	301	50	to	to	TO
cord-290566-tmsocyfc	301	51	downregulate	downregulate	VB
cord-290566-tmsocyfc	301	52	the	the	DT
cord-290566-tmsocyfc	301	53	inflammatory	inflammatory	JJ
cord-290566-tmsocyfc	301	54	disease	disease	NN
cord-290566-tmsocyfc	301	55	process	process	NN
cord-290566-tmsocyfc	301	56	through	through	IN
cord-290566-tmsocyfc	301	57	bystander	bystander	NN
cord-290566-tmsocyfc	301	58	suppression	suppression	NN
cord-290566-tmsocyfc	301	59	.	.	.
cord-290566-tmsocyfc	302	1	Glatiramer	glatiramer	JJ
cord-290566-tmsocyfc	302	2	acetate	acetate	NN
cord-290566-tmsocyfc	302	3	(	(	-LRB-
cord-290566-tmsocyfc	302	4	GA	GA	NNP
cord-290566-tmsocyfc	302	5	;	;	:
cord-290566-tmsocyfc	302	6	Copolymer-1	Copolymer-1	NNP
cord-290566-tmsocyfc	302	7	;	;	:
cord-290566-tmsocyfc	302	8	Copaxone	Copaxone	NNP
cord-290566-tmsocyfc	302	9	)	)	-RRB-
cord-290566-tmsocyfc	302	10	is	be	VBZ
cord-290566-tmsocyfc	302	11	an	an	DT
cord-290566-tmsocyfc	302	12	FDA	FDA	NNP
cord-290566-tmsocyfc	302	13	approved	approve	VBN
cord-290566-tmsocyfc	302	14	therapy	therapy	NN
cord-290566-tmsocyfc	302	15	for	for	IN
cord-290566-tmsocyfc	302	16	the	the	DT
cord-290566-tmsocyfc	302	17	treatment	treatment	NN
cord-290566-tmsocyfc	302	18	of	of	IN
cord-290566-tmsocyfc	302	19	RRMS	RRMS	NNP
cord-290566-tmsocyfc	302	20	.	.	.
cord-290566-tmsocyfc	303	1	GA	GA	NNP
cord-290566-tmsocyfc	303	2	is	be	VBZ
cord-290566-tmsocyfc	303	3	an	an	DT
cord-290566-tmsocyfc	303	4	APL	APL	NNP
cord-290566-tmsocyfc	303	5	that	that	WDT
cord-290566-tmsocyfc	303	6	was	be	VBD
cord-290566-tmsocyfc	303	7	originally	originally	RB
cord-290566-tmsocyfc	303	8	developed	develop	VBN
cord-290566-tmsocyfc	303	9	to	to	TO
cord-290566-tmsocyfc	303	10	mimic	mimic	VB
cord-290566-tmsocyfc	303	11	MBP	MBP	NNP
cord-290566-tmsocyfc	303	12	.	.	.
cord-290566-tmsocyfc	304	1	It	-PRON-	PRP
cord-290566-tmsocyfc	304	2	is	be	VBZ
cord-290566-tmsocyfc	304	3	composed	compose	VBN
cord-290566-tmsocyfc	304	4	of	of	IN
cord-290566-tmsocyfc	304	5	a	a	DT
cord-290566-tmsocyfc	304	6	random	random	JJ
cord-290566-tmsocyfc	304	7	sequence	sequence	NN
cord-290566-tmsocyfc	304	8	of	of	IN
cord-290566-tmsocyfc	304	9	the	the	DT
cord-290566-tmsocyfc	304	10	amino	amino	NN
cord-290566-tmsocyfc	304	11	acids	acid	NNS
cord-290566-tmsocyfc	304	12	glutamic	glutamic	NN
cord-290566-tmsocyfc	304	13	acid	acid	NN
cord-290566-tmsocyfc	304	14	,	,	,
cord-290566-tmsocyfc	304	15	lysine	lysine	NN
cord-290566-tmsocyfc	304	16	,	,	,
cord-290566-tmsocyfc	304	17	alanine	alanine	NN
cord-290566-tmsocyfc	304	18	,	,	,
cord-290566-tmsocyfc	304	19	and	and	CC
cord-290566-tmsocyfc	304	20	tyrosine	tyrosine	NN
cord-290566-tmsocyfc	304	21	present	present	JJ
cord-290566-tmsocyfc	304	22	in	in	IN
cord-290566-tmsocyfc	304	23	a	a	DT
cord-290566-tmsocyfc	304	24	specific	specific	JJ
cord-290566-tmsocyfc	304	25	molar	molar	JJ
cord-290566-tmsocyfc	304	26	ratio	ratio	NN
cord-290566-tmsocyfc	304	27	(	(	-LRB-
cord-290566-tmsocyfc	304	28	0.14:0.34:0.43:0.09	0.14:0.34:0.43:0.09	CD
cord-290566-tmsocyfc	304	29	)	)	-RRB-
cord-290566-tmsocyfc	304	30	.	.	.
cord-290566-tmsocyfc	305	1	Copaxone	Copaxone	NNP
cord-290566-tmsocyfc	305	2	is	be	VBZ
cord-290566-tmsocyfc	305	3	administered	administer	VBN
cord-290566-tmsocyfc	305	4	by	by	IN
cord-290566-tmsocyfc	305	5	daily	daily	JJ
cord-290566-tmsocyfc	305	6	subcutaneous	subcutaneous	JJ
cord-290566-tmsocyfc	305	7	injection	injection	NN
cord-290566-tmsocyfc	305	8	,	,	,
cord-290566-tmsocyfc	305	9	and	and	CC
cord-290566-tmsocyfc	305	10	in	in	IN
cord-290566-tmsocyfc	305	11	a	a	DT
cord-290566-tmsocyfc	305	12	phase	phase	NN
cord-290566-tmsocyfc	305	13	III	iii	CD
cord-290566-tmsocyfc	305	14	clinical	clinical	JJ
cord-290566-tmsocyfc	305	15	trial	trial	NN
cord-290566-tmsocyfc	305	16	was	be	VBD
cord-290566-tmsocyfc	305	17	found	find	VBN
cord-290566-tmsocyfc	305	18	to	to	TO
cord-290566-tmsocyfc	305	19	reduce	reduce	VB
cord-290566-tmsocyfc	305	20	relapse	relapse	NN
cord-290566-tmsocyfc	305	21	frequency	frequency	NN
cord-290566-tmsocyfc	305	22	by	by	IN
cord-290566-tmsocyfc	305	23	29	29	CD
cord-290566-tmsocyfc	305	24	%	%	NN
cord-290566-tmsocyfc	305	25	,	,	,
cord-290566-tmsocyfc	305	26	as	as	RB
cord-290566-tmsocyfc	305	27	well	well	RB
cord-290566-tmsocyfc	305	28	as	as	IN
cord-290566-tmsocyfc	305	29	decrease	decrease	VB
cord-290566-tmsocyfc	305	30	the	the	DT
cord-290566-tmsocyfc	305	31	incidence	incidence	NN
cord-290566-tmsocyfc	305	32	of	of	IN
cord-290566-tmsocyfc	305	33	new	new	JJ
cord-290566-tmsocyfc	305	34	gadolinium	gadolinium	NN
cord-290566-tmsocyfc	305	35	enhancing	enhance	VBG
cord-290566-tmsocyfc	305	36	lesions	lesion	NNS
cord-290566-tmsocyfc	305	37	on	on	IN
cord-290566-tmsocyfc	305	38	MRI	MRI	NNP
cord-290566-tmsocyfc	305	39	(	(	-LRB-
cord-290566-tmsocyfc	305	40	Ge	Ge	NNP
cord-290566-tmsocyfc	305	41	et	et	NNP
cord-290566-tmsocyfc	305	42	al	al	NNP
cord-290566-tmsocyfc	305	43	.	.	NNP
cord-290566-tmsocyfc	305	44	,	,	,
cord-290566-tmsocyfc	305	45	2000	2000	CD
cord-290566-tmsocyfc	305	46	;	;	:
cord-290566-tmsocyfc	305	47	Johnson	Johnson	NNP
cord-290566-tmsocyfc	305	48	et	et	NNP
cord-290566-tmsocyfc	305	49	al	al	NNP
cord-290566-tmsocyfc	305	50	.	.	NNP
cord-290566-tmsocyfc	305	51	,	,	,
cord-290566-tmsocyfc	305	52	,	,	,
cord-290566-tmsocyfc	305	53	2001	2001	CD
cord-290566-tmsocyfc	305	54	.	.	.
cord-290566-tmsocyfc	306	1	Despite	despite	IN
cord-290566-tmsocyfc	306	2	its	-PRON-	PRP$
cord-290566-tmsocyfc	306	3	crude	crude	JJ
cord-290566-tmsocyfc	306	4	resemblance	resemblance	NN
cord-290566-tmsocyfc	306	5	to	to	IN
cord-290566-tmsocyfc	306	6	MBP	MBP	NNP
cord-290566-tmsocyfc	306	7	,	,	,
cord-290566-tmsocyfc	306	8	evidence	evidence	NN
cord-290566-tmsocyfc	306	9	from	from	IN
cord-290566-tmsocyfc	306	10	several	several	JJ
cord-290566-tmsocyfc	306	11	studies	study	NNS
cord-290566-tmsocyfc	306	12	showing	show	VBG
cord-290566-tmsocyfc	306	13	GA	GA	NNP
cord-290566-tmsocyfc	306	14	stimulates	stimulate	VBZ
cord-290566-tmsocyfc	306	15	several	several	JJ
cord-290566-tmsocyfc	306	16	nonmyelin	nonmyelin	NN
cord-290566-tmsocyfc	306	17	antigen	antigen	NN
cord-290566-tmsocyfc	306	18	T	T	NNP
cord-290566-tmsocyfc	306	19	-	-	HYPH
cord-290566-tmsocyfc	306	20	cell	cell	NN
cord-290566-tmsocyfc	306	21	lines	line	NNS
cord-290566-tmsocyfc	306	22	suggests	suggest	VBZ
cord-290566-tmsocyfc	306	23	that	that	IN
cord-290566-tmsocyfc	306	24	GA	GA	NNP
cord-290566-tmsocyfc	306	25	acts	act	VBZ
cord-290566-tmsocyfc	306	26	as	as	IN
cord-290566-tmsocyfc	306	27	a	a	DT
cord-290566-tmsocyfc	306	28	'	'	``
cord-290566-tmsocyfc	306	29	'	'	``
cord-290566-tmsocyfc	306	30	universal	universal	JJ
cord-290566-tmsocyfc	306	31	'	'	''
cord-290566-tmsocyfc	306	32	'	'	''
cord-290566-tmsocyfc	306	33	or	or	CC
cord-290566-tmsocyfc	306	34	degenerate	degenerate	VB
cord-290566-tmsocyfc	306	35	T	t	NN
cord-290566-tmsocyfc	306	36	-	-	HYPH
cord-290566-tmsocyfc	306	37	cell	cell	NN
cord-290566-tmsocyfc	306	38	antigen	antigen	NN
cord-290566-tmsocyfc	306	39	(	(	-LRB-
cord-290566-tmsocyfc	306	40	Duda	Duda	NNP
cord-290566-tmsocyfc	306	41	et	et	FW
cord-290566-tmsocyfc	306	42	al	al	NNP
cord-290566-tmsocyfc	306	43	.	.	NNP
cord-290566-tmsocyfc	306	44	,	,	,
cord-290566-tmsocyfc	306	45	2000	2000	CD
cord-290566-tmsocyfc	306	46	)	)	-RRB-
cord-290566-tmsocyfc	306	47	.	.	.
cord-290566-tmsocyfc	307	1	GA	GA	NNP
cord-290566-tmsocyfc	307	2	has	have	VBZ
cord-290566-tmsocyfc	307	3	been	be	VBN
cord-290566-tmsocyfc	307	4	shown	show	VBN
cord-290566-tmsocyfc	307	5	to	to	TO
cord-290566-tmsocyfc	307	6	inhibit	inhibit	VB
cord-290566-tmsocyfc	307	7	responses	response	NNS
cord-290566-tmsocyfc	307	8	to	to	IN
cord-290566-tmsocyfc	307	9	MBP	MBP	NNP
cord-290566-tmsocyfc	307	10	-	-	HYPH
cord-290566-tmsocyfc	307	11	specific	specific	JJ
cord-290566-tmsocyfc	307	12	T	t	NN
cord-290566-tmsocyfc	307	13	-	-	HYPH
cord-290566-tmsocyfc	307	14	cell	cell	NN
cord-290566-tmsocyfc	307	15	lines	line	NNS
cord-290566-tmsocyfc	307	16	in	in	IN
cord-290566-tmsocyfc	307	17	vitro	vitro	FW
cord-290566-tmsocyfc	307	18	(	(	-LRB-
cord-290566-tmsocyfc	307	19	Racke	Racke	NNP
cord-290566-tmsocyfc	307	20	et	et	NNP
cord-290566-tmsocyfc	307	21	al	al	NNP
cord-290566-tmsocyfc	307	22	.	.	NNP
cord-290566-tmsocyfc	307	23	,	,	,
cord-290566-tmsocyfc	307	24	1992	1992	CD
cord-290566-tmsocyfc	307	25	)	)	-RRB-
cord-290566-tmsocyfc	307	26	,	,	,
cord-290566-tmsocyfc	307	27	and	and	CC
cord-290566-tmsocyfc	307	28	in	in	IN
cord-290566-tmsocyfc	307	29	vivo	vivo	NN
cord-290566-tmsocyfc	307	30	treatment	treatment	NN
cord-290566-tmsocyfc	307	31	with	with	IN
cord-290566-tmsocyfc	307	32	GA	GA	NNP
cord-290566-tmsocyfc	307	33	induces	induce	VBZ
cord-290566-tmsocyfc	307	34	a	a	DT
cord-290566-tmsocyfc	307	35	hyporesponsiveness	hyporesponsiveness	NN
cord-290566-tmsocyfc	307	36	to	to	IN
cord-290566-tmsocyfc	307	37	this	this	DT
cord-290566-tmsocyfc	307	38	antigen	antigen	NN
cord-290566-tmsocyfc	307	39	(	(	-LRB-
cord-290566-tmsocyfc	307	40	Schmied	Schmied	NNP
cord-290566-tmsocyfc	307	41	et	et	NNP
cord-290566-tmsocyfc	307	42	al	al	NNP
cord-290566-tmsocyfc	307	43	.	.	NNP
cord-290566-tmsocyfc	307	44	,	,	,
cord-290566-tmsocyfc	307	45	2003	2003	CD
cord-290566-tmsocyfc	307	46	)	)	-RRB-
cord-290566-tmsocyfc	307	47	.	.	.
cord-290566-tmsocyfc	308	1	Interestingly	interestingly	RB
cord-290566-tmsocyfc	308	2	,	,	,
cord-290566-tmsocyfc	308	3	GA	GA	NNP
cord-290566-tmsocyfc	308	4	-	-	HYPH
cord-290566-tmsocyfc	308	5	reactive	reactive	JJ
cord-290566-tmsocyfc	308	6	T	T	NNP
cord-290566-tmsocyfc	308	7	-	-	HYPH
cord-290566-tmsocyfc	308	8	cell	cell	NN
cord-290566-tmsocyfc	308	9	lines	line	NNS
cord-290566-tmsocyfc	308	10	isolated	isolate	VBN
cord-290566-tmsocyfc	308	11	from	from	IN
cord-290566-tmsocyfc	308	12	both	both	CC
cord-290566-tmsocyfc	308	13	treated	treat	VBN
cord-290566-tmsocyfc	308	14	patients	patient	NNS
cord-290566-tmsocyfc	308	15	as	as	RB
cord-290566-tmsocyfc	308	16	well	well	RB
cord-290566-tmsocyfc	308	17	as	as	IN
cord-290566-tmsocyfc	308	18	untreated	untreated	JJ
cord-290566-tmsocyfc	308	19	controls	control	NNS
cord-290566-tmsocyfc	308	20	were	be	VBD
cord-290566-tmsocyfc	308	21	found	find	VBN
cord-290566-tmsocyfc	308	22	to	to	TO
cord-290566-tmsocyfc	308	23	cross	cross	VB
cord-290566-tmsocyfc	308	24	-	-	VB
cord-290566-tmsocyfc	308	25	react	react	VB
cord-290566-tmsocyfc	308	26	with	with	IN
cord-290566-tmsocyfc	308	27	a	a	DT
cord-290566-tmsocyfc	308	28	variety	variety	NN
cord-290566-tmsocyfc	308	29	of	of	IN
cord-290566-tmsocyfc	308	30	peptides	peptide	NNS
cord-290566-tmsocyfc	308	31	,	,	,
cord-290566-tmsocyfc	308	32	suggesting	suggest	VBG
cord-290566-tmsocyfc	308	33	degenerate	degenerate	JJ
cord-290566-tmsocyfc	308	34	antigenicity	antigenicity	NN
cord-290566-tmsocyfc	308	35	.	.	.
cord-290566-tmsocyfc	309	1	In	in	IN
cord-290566-tmsocyfc	309	2	addition	addition	NN
cord-290566-tmsocyfc	309	3	,	,	,
cord-290566-tmsocyfc	309	4	Th2	Th2	NNP
cord-290566-tmsocyfc	309	5	cytokine	cytokine	NN
cord-290566-tmsocyfc	309	6	deviation	deviation	NN
cord-290566-tmsocyfc	309	7	was	be	VBD
cord-290566-tmsocyfc	309	8	noted	note	VBN
cord-290566-tmsocyfc	309	9	in	in	IN
cord-290566-tmsocyfc	309	10	GA	GA	NNP
cord-290566-tmsocyfc	309	11	-	-	HYPH
cord-290566-tmsocyfc	309	12	reactive	reactive	JJ
cord-290566-tmsocyfc	309	13	T	t	NN
cord-290566-tmsocyfc	309	14	-	-	HYPH
cord-290566-tmsocyfc	309	15	cell	cell	NN
cord-290566-tmsocyfc	309	16	lines	line	NNS
cord-290566-tmsocyfc	309	17	(	(	-LRB-
cord-290566-tmsocyfc	309	18	Duda	Duda	NNP
cord-290566-tmsocyfc	309	19	et	et	FW
cord-290566-tmsocyfc	309	20	al	al	NNP
cord-290566-tmsocyfc	309	21	.	.	NNP
cord-290566-tmsocyfc	309	22	,	,	,
cord-290566-tmsocyfc	309	23	2000	2000	CD
cord-290566-tmsocyfc	309	24	)	)	-RRB-
cord-290566-tmsocyfc	309	25	.	.	.
cord-290566-tmsocyfc	310	1	In	in	IN
cord-290566-tmsocyfc	310	2	the	the	DT
cord-290566-tmsocyfc	310	3	EAE	EAE	NNP
cord-290566-tmsocyfc	310	4	model	model	NN
cord-290566-tmsocyfc	310	5	,	,	,
cord-290566-tmsocyfc	310	6	Th2-producing	Th2-producing	NNP
cord-290566-tmsocyfc	310	7	GA	GA	NNP
cord-290566-tmsocyfc	310	8	-	-	HYPH
cord-290566-tmsocyfc	310	9	reactive	reactive	JJ
cord-290566-tmsocyfc	310	10	T	t	NN
cord-290566-tmsocyfc	310	11	cells	cell	NNS
cord-290566-tmsocyfc	310	12	were	be	VBD
cord-290566-tmsocyfc	310	13	shown	show	VBN
cord-290566-tmsocyfc	310	14	to	to	TO
cord-290566-tmsocyfc	310	15	accumulate	accumulate	VB
cord-290566-tmsocyfc	310	16	in	in	IN
cord-290566-tmsocyfc	310	17	the	the	DT
cord-290566-tmsocyfc	310	18	CNS	CNS	NNP
cord-290566-tmsocyfc	310	19	and	and	CC
cord-290566-tmsocyfc	310	20	attenuate	attenuate	VB
cord-290566-tmsocyfc	310	21	disease	disease	NN
cord-290566-tmsocyfc	310	22	(	(	-LRB-
cord-290566-tmsocyfc	310	23	Aharoni	Aharoni	NNP
cord-290566-tmsocyfc	310	24	et	et	FW
cord-290566-tmsocyfc	310	25	al	al	NNP
cord-290566-tmsocyfc	310	26	.	.	NNP
cord-290566-tmsocyfc	310	27	,	,	,
cord-290566-tmsocyfc	310	28	2000	2000	CD
cord-290566-tmsocyfc	310	29	)	)	-RRB-
cord-290566-tmsocyfc	310	30	.	.	.
cord-290566-tmsocyfc	311	1	Thus	thus	RB
cord-290566-tmsocyfc	311	2	,	,	,
cord-290566-tmsocyfc	311	3	the	the	DT
cord-290566-tmsocyfc	311	4	principal	principal	JJ
cord-290566-tmsocyfc	311	5	mechanism	mechanism	NN
cord-290566-tmsocyfc	311	6	of	of	IN
cord-290566-tmsocyfc	311	7	action	action	NN
cord-290566-tmsocyfc	311	8	of	of	IN
cord-290566-tmsocyfc	311	9	Copaxone	Copaxone	NNP
cord-290566-tmsocyfc	311	10	may	may	MD
cord-290566-tmsocyfc	311	11	be	be	VB
cord-290566-tmsocyfc	311	12	the	the	DT
cord-290566-tmsocyfc	311	13	induction	induction	NN
cord-290566-tmsocyfc	311	14	of	of	IN
cord-290566-tmsocyfc	311	15	Th2	Th2	NNP
cord-290566-tmsocyfc	311	16	responses	response	NNS
cord-290566-tmsocyfc	311	17	,	,	,
cord-290566-tmsocyfc	311	18	which	which	WDT
cord-290566-tmsocyfc	311	19	exert	exert	VBP
cord-290566-tmsocyfc	311	20	bystander	bystander	NN
cord-290566-tmsocyfc	311	21	suppression	suppression	NN
cord-290566-tmsocyfc	311	22	of	of	IN
cord-290566-tmsocyfc	311	23	inflammation	inflammation	NN
cord-290566-tmsocyfc	311	24	within	within	IN
cord-290566-tmsocyfc	311	25	the	the	DT
cord-290566-tmsocyfc	311	26	CNS	CNS	NNP
cord-290566-tmsocyfc	311	27	.	.	.
cord-290566-tmsocyfc	312	1	APLs	APLs	NNP
cord-290566-tmsocyfc	312	2	targeting	target	VBG
cord-290566-tmsocyfc	312	3	MBP	MBP	NNP
cord-290566-tmsocyfc	312	4	have	have	VBP
cord-290566-tmsocyfc	312	5	been	be	VBN
cord-290566-tmsocyfc	312	6	widely	widely	RB
cord-290566-tmsocyfc	312	7	studied	study	VBN
cord-290566-tmsocyfc	312	8	in	in	IN
cord-290566-tmsocyfc	312	9	MS	MS	NNP
cord-290566-tmsocyfc	312	10	because	because	IN
cord-290566-tmsocyfc	312	11	of	of	IN
cord-290566-tmsocyfc	312	12	the	the	DT
cord-290566-tmsocyfc	312	13	interest	interest	NN
cord-290566-tmsocyfc	312	14	in	in	IN
cord-290566-tmsocyfc	312	15	this	this	DT
cord-290566-tmsocyfc	312	16	potential	potential	JJ
cord-290566-tmsocyfc	312	17	autoantigen	autoantigen	NN
cord-290566-tmsocyfc	312	18	.	.	.
cord-290566-tmsocyfc	313	1	An	an	DT
cord-290566-tmsocyfc	313	2	APL	APL	NNP
cord-290566-tmsocyfc	313	3	to	to	IN
cord-290566-tmsocyfc	313	4	MBP	MBP	NNP
cord-290566-tmsocyfc	313	5	87	87	CD
cord-290566-tmsocyfc	313	6	-	-	SYM
cord-290566-tmsocyfc	313	7	99	99	CD
cord-290566-tmsocyfc	313	8	peptide	peptide	NN
cord-290566-tmsocyfc	313	9	was	be	VBD
cord-290566-tmsocyfc	313	10	shown	show	VBN
cord-290566-tmsocyfc	313	11	to	to	TO
cord-290566-tmsocyfc	313	12	be	be	VB
cord-290566-tmsocyfc	313	13	eVective	eVective	NNP
cord-290566-tmsocyfc	313	14	in	in	IN
cord-290566-tmsocyfc	313	15	ameliorating	ameliorate	VBG
cord-290566-tmsocyfc	313	16	disease	disease	NN
cord-290566-tmsocyfc	313	17	in	in	IN
cord-290566-tmsocyfc	313	18	the	the	DT
cord-290566-tmsocyfc	313	19	EAE	EAE	NNP
cord-290566-tmsocyfc	313	20	model	model	NN
cord-290566-tmsocyfc	314	1	(	(	-LRB-
cord-290566-tmsocyfc	314	2	Karin	Karin	NNP
cord-290566-tmsocyfc	314	3	et	et	NNP
cord-290566-tmsocyfc	314	4	al	al	NNP
cord-290566-tmsocyfc	314	5	.	.	NNP
cord-290566-tmsocyfc	314	6	,	,	,
cord-290566-tmsocyfc	314	7	1994	1994	CD
cord-290566-tmsocyfc	314	8	)	)	-RRB-
cord-290566-tmsocyfc	314	9	.	.	.
cord-290566-tmsocyfc	315	1	An	an	DT
cord-290566-tmsocyfc	315	2	initial	initial	JJ
cord-290566-tmsocyfc	315	3	phase	phase	NN
cord-290566-tmsocyfc	315	4	I	-PRON-	PRP
cord-290566-tmsocyfc	315	5	clinical	clinical	JJ
cord-290566-tmsocyfc	315	6	trial	trial	NN
cord-290566-tmsocyfc	315	7	tested	test	VBD
cord-290566-tmsocyfc	315	8	four	four	CD
cord-290566-tmsocyfc	315	9	doses	dose	NNS
cord-290566-tmsocyfc	315	10	of	of	IN
cord-290566-tmsocyfc	315	11	an	an	DT
cord-290566-tmsocyfc	315	12	APL	APL	NNP
cord-290566-tmsocyfc	315	13	to	to	IN
cord-290566-tmsocyfc	315	14	MBP	MBP	NNP
cord-290566-tmsocyfc	315	15	83	83	CD
cord-290566-tmsocyfc	315	16	-	-	SYM
cord-290566-tmsocyfc	315	17	99	99	CD
cord-290566-tmsocyfc	315	18	administered	administer	VBN
cord-290566-tmsocyfc	315	19	subcutaneously	subcutaneously	RB
cord-290566-tmsocyfc	315	20	for	for	IN
cord-290566-tmsocyfc	315	21	4	4	CD
cord-290566-tmsocyfc	315	22	weeks	week	NNS
cord-290566-tmsocyfc	315	23	demonstrated	demonstrate	VBD
cord-290566-tmsocyfc	315	24	no	no	DT
cord-290566-tmsocyfc	315	25	safety	safety	NN
cord-290566-tmsocyfc	315	26	concerns	concern	NNS
cord-290566-tmsocyfc	315	27	(	(	-LRB-
cord-290566-tmsocyfc	315	28	Bielekova	Bielekova	NNP
cord-290566-tmsocyfc	315	29	and	and	CC
cord-290566-tmsocyfc	315	30	Martin	Martin	NNP
cord-290566-tmsocyfc	315	31	,	,	,
cord-290566-tmsocyfc	315	32	2001	2001	CD
cord-290566-tmsocyfc	315	33	)	)	-RRB-
cord-290566-tmsocyfc	315	34	.	.	.
cord-290566-tmsocyfc	316	1	Two	two	CD
cord-290566-tmsocyfc	316	2	phase	phase	NN
cord-290566-tmsocyfc	316	3	II	ii	CD
cord-290566-tmsocyfc	316	4	trials	trial	NNS
cord-290566-tmsocyfc	316	5	using	use	VBG
cord-290566-tmsocyfc	316	6	MBP	MBP	NNP
cord-290566-tmsocyfc	316	7	83	83	CD
cord-290566-tmsocyfc	316	8	-	-	SYM
cord-290566-tmsocyfc	316	9	99	99	CD
cord-290566-tmsocyfc	316	10	APLs	apl	NNS
cord-290566-tmsocyfc	316	11	were	be	VBD
cord-290566-tmsocyfc	316	12	initiated	initiate	VBN
cord-290566-tmsocyfc	316	13	:	:	:
cord-290566-tmsocyfc	316	14	A	a	DT
cord-290566-tmsocyfc	316	15	small	small	JJ
cord-290566-tmsocyfc	316	16	NIH	NIH	NNP
cord-290566-tmsocyfc	316	17	-	-	HYPH
cord-290566-tmsocyfc	316	18	based	base	VBN
cord-290566-tmsocyfc	316	19	trial	trial	NN
cord-290566-tmsocyfc	316	20	tested	test	VBD
cord-290566-tmsocyfc	316	21	the	the	DT
cord-290566-tmsocyfc	316	22	highest	high	JJS
cord-290566-tmsocyfc	316	23	dose	dose	NN
cord-290566-tmsocyfc	316	24	of	of	IN
cord-290566-tmsocyfc	316	25	APL	APL	NNP
cord-290566-tmsocyfc	316	26	CGP77116	CGP77116	NNP
cord-290566-tmsocyfc	316	27	(	(	-LRB-
cord-290566-tmsocyfc	316	28	50	50	CD
cord-290566-tmsocyfc	316	29	mg	mg	NNS
cord-290566-tmsocyfc	316	30	)	)	-RRB-
cord-290566-tmsocyfc	316	31	administered	administer	VBD
cord-290566-tmsocyfc	316	32	weekly	weekly	RB
cord-290566-tmsocyfc	316	33	for	for	IN
cord-290566-tmsocyfc	316	34	9	9	CD
cord-290566-tmsocyfc	316	35	months	month	NNS
cord-290566-tmsocyfc	316	36	.	.	.
cord-290566-tmsocyfc	317	1	Three	three	CD
cord-290566-tmsocyfc	317	2	of	of	IN
cord-290566-tmsocyfc	317	3	eight	eight	CD
cord-290566-tmsocyfc	317	4	patients	patient	NNS
cord-290566-tmsocyfc	317	5	developed	develop	VBD
cord-290566-tmsocyfc	317	6	atypical	atypical	JJ
cord-290566-tmsocyfc	317	7	MS	MS	NNP
cord-290566-tmsocyfc	317	8	exacerbations	exacerbation	NNS
cord-290566-tmsocyfc	317	9	,	,	,
cord-290566-tmsocyfc	317	10	characterized	characterize	VBN
cord-290566-tmsocyfc	317	11	by	by	IN
cord-290566-tmsocyfc	317	12	a	a	DT
cord-290566-tmsocyfc	317	13	high	high	JJ
cord-290566-tmsocyfc	317	14	gadolinium	gadolinium	NN
cord-290566-tmsocyfc	317	15	-	-	HYPH
cord-290566-tmsocyfc	317	16	enhancing	enhance	VBG
cord-290566-tmsocyfc	317	17	lesion	lesion	NN
cord-290566-tmsocyfc	317	18	load	load	NN
cord-290566-tmsocyfc	317	19	,	,	,
cord-290566-tmsocyfc	317	20	tumefactivetype	tumefactivetype	NN
cord-290566-tmsocyfc	317	21	lesion	lesion	NN
cord-290566-tmsocyfc	317	22	,	,	,
cord-290566-tmsocyfc	317	23	or	or	CC
cord-290566-tmsocyfc	317	24	a	a	DT
cord-290566-tmsocyfc	317	25	flaccid	flaccid	JJ
cord-290566-tmsocyfc	317	26	paralysis	paralysis	NN
cord-290566-tmsocyfc	317	27	with	with	IN
cord-290566-tmsocyfc	317	28	inflammatory	inflammatory	JJ
cord-290566-tmsocyfc	317	29	involvement	involvement	NN
cord-290566-tmsocyfc	317	30	of	of	IN
cord-290566-tmsocyfc	317	31	the	the	DT
cord-290566-tmsocyfc	317	32	peripheral	peripheral	JJ
cord-290566-tmsocyfc	317	33	THE	the	DT
cord-290566-tmsocyfc	317	34	ROLE	role	NN
cord-290566-tmsocyfc	317	35	OF	of	IN
cord-290566-tmsocyfc	317	36	CD4	CD4	NNP
cord-290566-tmsocyfc	317	37	T	T	NNP
cord-290566-tmsocyfc	317	38	CELLS	cell	VBN
cord-290566-tmsocyfc	317	39	IN	in	IN
cord-290566-tmsocyfc	317	40	THE	the	DT
cord-290566-tmsocyfc	317	41	PATHOGENESIS	PATHOGENESIS	NNP
cord-290566-tmsocyfc	317	42	nervous	nervous	JJ
cord-290566-tmsocyfc	317	43	system	system	NN
cord-290566-tmsocyfc	317	44	.	.	.
cord-290566-tmsocyfc	318	1	2/3	2/3	CD
cord-290566-tmsocyfc	318	2	of	of	IN
cord-290566-tmsocyfc	318	3	exacerbations	exacerbation	NNS
cord-290566-tmsocyfc	318	4	,	,	,
cord-290566-tmsocyfc	318	5	correlated	correlate	VBN
cord-290566-tmsocyfc	318	6	with	with	IN
cord-290566-tmsocyfc	318	7	enhanced	enhanced	JJ
cord-290566-tmsocyfc	318	8	reactivity	reactivity	NN
cord-290566-tmsocyfc	318	9	to	to	IN
cord-290566-tmsocyfc	318	10	MBP	MBP	NNP
cord-290566-tmsocyfc	318	11	.	.	.
cord-290566-tmsocyfc	319	1	A	a	DT
cord-290566-tmsocyfc	319	2	second	second	JJ
cord-290566-tmsocyfc	319	3	larger	large	JJR
cord-290566-tmsocyfc	319	4	multicenter	multicenter	JJ
cord-290566-tmsocyfc	319	5	study	study	NN
cord-290566-tmsocyfc	319	6	testing	test	VBG
cord-290566-tmsocyfc	319	7	three	three	CD
cord-290566-tmsocyfc	319	8	doses	dose	NNS
cord-290566-tmsocyfc	319	9	of	of	IN
cord-290566-tmsocyfc	319	10	APL	APL	NNP
cord-290566-tmsocyfc	319	11	NBI-5788	NBI-5788	NNP
cord-290566-tmsocyfc	319	12	(	(	-LRB-
cord-290566-tmsocyfc	319	13	5	5	CD
cord-290566-tmsocyfc	319	14	,	,	,
cord-290566-tmsocyfc	319	15	20	20	CD
cord-290566-tmsocyfc	319	16	,	,	,
cord-290566-tmsocyfc	319	17	or	or	CC
cord-290566-tmsocyfc	319	18	50	50	CD
cord-290566-tmsocyfc	319	19	mg	mg	NNS
cord-290566-tmsocyfc	319	20	)	)	-RRB-
cord-290566-tmsocyfc	319	21	versus	versus	IN
cord-290566-tmsocyfc	319	22	placebo	placebo	NN
cord-290566-tmsocyfc	319	23	in	in	IN
cord-290566-tmsocyfc	319	24	144	144	CD
cord-290566-tmsocyfc	319	25	total	total	JJ
cord-290566-tmsocyfc	319	26	patients	patient	NNS
cord-290566-tmsocyfc	319	27	was	be	VBD
cord-290566-tmsocyfc	319	28	terminated	terminate	VBN
cord-290566-tmsocyfc	319	29	because	because	IN
cord-290566-tmsocyfc	319	30	of	of	IN
cord-290566-tmsocyfc	319	31	the	the	DT
cord-290566-tmsocyfc	319	32	occurrence	occurrence	NN
cord-290566-tmsocyfc	319	33	of	of	IN
cord-290566-tmsocyfc	319	34	APL	APL	NNP
cord-290566-tmsocyfc	319	35	-	-	HYPH
cord-290566-tmsocyfc	319	36	induced	induce	VBN
cord-290566-tmsocyfc	319	37	systemic	systemic	JJ
cord-290566-tmsocyfc	319	38	hypersensitivity	hypersensitivity	NN
cord-290566-tmsocyfc	319	39	reactions	reaction	NNS
cord-290566-tmsocyfc	319	40	in	in	IN
cord-290566-tmsocyfc	319	41	9	9	CD
cord-290566-tmsocyfc	319	42	%	%	NN
cord-290566-tmsocyfc	319	43	of	of	IN
cord-290566-tmsocyfc	319	44	enrolled	enrol	VBN
cord-290566-tmsocyfc	319	45	patients	patient	NNS
cord-290566-tmsocyfc	319	46	(	(	-LRB-
cord-290566-tmsocyfc	319	47	Kappos	Kappos	NNP
cord-290566-tmsocyfc	319	48	et	et	NNP
cord-290566-tmsocyfc	319	49	al	al	NNP
cord-290566-tmsocyfc	319	50	.	.	NNP
cord-290566-tmsocyfc	319	51	,	,	,
cord-290566-tmsocyfc	319	52	2000	2000	CD
cord-290566-tmsocyfc	319	53	)	)	-RRB-
cord-290566-tmsocyfc	319	54	.	.	.
cord-290566-tmsocyfc	320	1	In	in	IN
cord-290566-tmsocyfc	320	2	both	both	DT
cord-290566-tmsocyfc	320	3	studies	study	NNS
cord-290566-tmsocyfc	320	4	,	,	,
cord-290566-tmsocyfc	320	5	enhanced	enhance	VBN
cord-290566-tmsocyfc	320	6	ex	ex	FW
cord-290566-tmsocyfc	320	7	vivo	vivo	NN
cord-290566-tmsocyfc	320	8	T	t	NN
cord-290566-tmsocyfc	320	9	-	-	HYPH
cord-290566-tmsocyfc	320	10	cell	cell	NN
cord-290566-tmsocyfc	320	11	responses	response	NNS
cord-290566-tmsocyfc	320	12	to	to	IN
cord-290566-tmsocyfc	320	13	APL	APL	NNP
cord-290566-tmsocyfc	320	14	were	be	VBD
cord-290566-tmsocyfc	320	15	observed	observe	VBN
cord-290566-tmsocyfc	320	16	following	follow	VBG
cord-290566-tmsocyfc	320	17	treatment	treatment	NN
cord-290566-tmsocyfc	320	18	.	.	.
cord-290566-tmsocyfc	321	1	In	in	IN
cord-290566-tmsocyfc	321	2	patients	patient	NNS
cord-290566-tmsocyfc	321	3	who	who	WP
cord-290566-tmsocyfc	321	4	developed	develop	VBD
cord-290566-tmsocyfc	321	5	hypersensitivity	hypersensitivity	NN
cord-290566-tmsocyfc	321	6	reactions	reaction	NNS
cord-290566-tmsocyfc	321	7	,	,	,
cord-290566-tmsocyfc	321	8	enhanced	enhance	VBD
cord-290566-tmsocyfc	321	9	Th2	th2	CD
cord-290566-tmsocyfc	321	10	responses	response	NNS
cord-290566-tmsocyfc	321	11	to	to	IN
cord-290566-tmsocyfc	321	12	the	the	DT
cord-290566-tmsocyfc	321	13	APL	APL	NNP
cord-290566-tmsocyfc	321	14	could	could	MD
cord-290566-tmsocyfc	321	15	be	be	VB
cord-290566-tmsocyfc	321	16	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	321	17	(	(	-LRB-
cord-290566-tmsocyfc	321	18	Kappos	Kappos	NNP
cord-290566-tmsocyfc	321	19	et	et	NNP
cord-290566-tmsocyfc	321	20	al	al	NNP
cord-290566-tmsocyfc	321	21	.	.	NNP
cord-290566-tmsocyfc	321	22	,	,	,
cord-290566-tmsocyfc	321	23	2000	2000	CD
cord-290566-tmsocyfc	321	24	)	)	-RRB-
cord-290566-tmsocyfc	321	25	.	.	.
cord-290566-tmsocyfc	322	1	Further	further	JJ
cord-290566-tmsocyfc	322	2	phase	phase	NN
cord-290566-tmsocyfc	322	3	II	ii	CD
cord-290566-tmsocyfc	322	4	studies	study	NNS
cord-290566-tmsocyfc	322	5	investigating	investigate	VBG
cord-290566-tmsocyfc	322	6	the	the	DT
cord-290566-tmsocyfc	322	7	eVects	evect	NNS
cord-290566-tmsocyfc	322	8	of	of	IN
cord-290566-tmsocyfc	322	9	low	low	JJ
cord-290566-tmsocyfc	322	10	-	-	HYPH
cord-290566-tmsocyfc	322	11	dose	dose	NN
cord-290566-tmsocyfc	322	12	APL	APL	NNP
cord-290566-tmsocyfc	322	13	(	(	-LRB-
cord-290566-tmsocyfc	322	14	NBI-5788	nbi-5788	NN
cord-290566-tmsocyfc	322	15	)	)	-RRB-
cord-290566-tmsocyfc	322	16	are	be	VBP
cord-290566-tmsocyfc	322	17	currently	currently	RB
cord-290566-tmsocyfc	322	18	undergoing	undergo	VBG
cord-290566-tmsocyfc	322	19	safety	safety	NN
cord-290566-tmsocyfc	322	20	evaluation	evaluation	NN
cord-290566-tmsocyfc	322	21	.	.	.
cord-290566-tmsocyfc	323	1	T	t	NN
cord-290566-tmsocyfc	323	2	-	-	HYPH
cord-290566-tmsocyfc	323	3	cell	cell	NN
cord-290566-tmsocyfc	323	4	vaccination	vaccination	NN
cord-290566-tmsocyfc	323	5	strategies	strategy	NNS
cord-290566-tmsocyfc	323	6	attempt	attempt	VBP
cord-290566-tmsocyfc	323	7	to	to	TO
cord-290566-tmsocyfc	323	8	eliminate	eliminate	VB
cord-290566-tmsocyfc	323	9	pathogenic	pathogenic	JJ
cord-290566-tmsocyfc	323	10	T	t	NN
cord-290566-tmsocyfc	323	11	cells	cell	NNS
cord-290566-tmsocyfc	323	12	through	through	IN
cord-290566-tmsocyfc	323	13	the	the	DT
cord-290566-tmsocyfc	323	14	enhancement	enhancement	NN
cord-290566-tmsocyfc	323	15	of	of	IN
cord-290566-tmsocyfc	323	16	regulatory	regulatory	JJ
cord-290566-tmsocyfc	323	17	immune	immune	JJ
cord-290566-tmsocyfc	323	18	responses	response	NNS
cord-290566-tmsocyfc	323	19	to	to	TO
cord-290566-tmsocyfc	323	20	autoreactive	autoreactive	VB
cord-290566-tmsocyfc	323	21	T	t	NN
cord-290566-tmsocyfc	323	22	cells	cell	NNS
cord-290566-tmsocyfc	323	23	.	.	.
cord-290566-tmsocyfc	324	1	This	this	DT
cord-290566-tmsocyfc	324	2	approach	approach	NN
cord-290566-tmsocyfc	324	3	requires	require	VBZ
cord-290566-tmsocyfc	324	4	the	the	DT
cord-290566-tmsocyfc	324	5	isolation	isolation	NN
cord-290566-tmsocyfc	324	6	of	of	IN
cord-290566-tmsocyfc	324	7	autoreactive	autoreactive	JJ
cord-290566-tmsocyfc	324	8	T	t	NN
cord-290566-tmsocyfc	324	9	-	-	HYPH
cord-290566-tmsocyfc	324	10	cell	cell	NN
cord-290566-tmsocyfc	324	11	clones	clone	NNS
cord-290566-tmsocyfc	324	12	from	from	IN
cord-290566-tmsocyfc	324	13	the	the	DT
cord-290566-tmsocyfc	324	14	individual	individual	JJ
cord-290566-tmsocyfc	324	15	patient	patient	NN
cord-290566-tmsocyfc	324	16	's	's	POS
cord-290566-tmsocyfc	324	17	blood	blood	NN
cord-290566-tmsocyfc	324	18	or	or	CC
cord-290566-tmsocyfc	324	19	CSF	CSF	NNP
cord-290566-tmsocyfc	324	20	,	,	,
cord-290566-tmsocyfc	324	21	and	and	CC
cord-290566-tmsocyfc	324	22	subcutaneous	subcutaneous	JJ
cord-290566-tmsocyfc	324	23	reinjection	reinjection	NN
cord-290566-tmsocyfc	324	24	in	in	IN
cord-290566-tmsocyfc	324	25	the	the	DT
cord-290566-tmsocyfc	324	26	form	form	NN
cord-290566-tmsocyfc	324	27	of	of	IN
cord-290566-tmsocyfc	324	28	an	an	DT
cord-290566-tmsocyfc	324	29	immunizing	immunize	VBG
cord-290566-tmsocyfc	324	30	vaccine	vaccine	NN
cord-290566-tmsocyfc	324	31	.	.	.
cord-290566-tmsocyfc	325	1	Pilot	pilot	NN
cord-290566-tmsocyfc	325	2	trials	trial	NNS
cord-290566-tmsocyfc	325	3	of	of	IN
cord-290566-tmsocyfc	325	4	T	t	NN
cord-290566-tmsocyfc	325	5	-	-	HYPH
cord-290566-tmsocyfc	325	6	cell	cell	NN
cord-290566-tmsocyfc	325	7	vaccination	vaccination	NN
cord-290566-tmsocyfc	325	8	with	with	IN
cord-290566-tmsocyfc	325	9	autologous	autologous	JJ
cord-290566-tmsocyfc	325	10	MBP	MBP	NNP
cord-290566-tmsocyfc	325	11	-	-	HYPH
cord-290566-tmsocyfc	325	12	specific	specific	JJ
cord-290566-tmsocyfc	325	13	T	t	NN
cord-290566-tmsocyfc	325	14	cells	cell	NNS
cord-290566-tmsocyfc	325	15	from	from	IN
cord-290566-tmsocyfc	325	16	peripheral	peripheral	JJ
cord-290566-tmsocyfc	325	17	blood	blood	NN
cord-290566-tmsocyfc	325	18	,	,	,
cord-290566-tmsocyfc	325	19	in	in	IN
cord-290566-tmsocyfc	325	20	28	28	CD
cord-290566-tmsocyfc	325	21	RRMS	rrm	NNS
cord-290566-tmsocyfc	325	22	and	and	CC
cord-290566-tmsocyfc	325	23	26	26	CD
cord-290566-tmsocyfc	325	24	SPMS	SPMS	NNP
cord-290566-tmsocyfc	325	25	patients	patient	NNS
cord-290566-tmsocyfc	325	26	,	,	,
cord-290566-tmsocyfc	325	27	demonstrated	demonstrate	VBD
cord-290566-tmsocyfc	325	28	a	a	DT
cord-290566-tmsocyfc	325	29	modest	modest	JJ
cord-290566-tmsocyfc	325	30	reduction	reduction	NN
cord-290566-tmsocyfc	325	31	in	in	IN
cord-290566-tmsocyfc	325	32	posttreatment	posttreatment	NN
cord-290566-tmsocyfc	325	33	relapse	relapse	NN
cord-290566-tmsocyfc	325	34	rate	rate	NN
cord-290566-tmsocyfc	325	35	(	(	-LRB-
cord-290566-tmsocyfc	325	36	Medaer	Medaer	NNP
cord-290566-tmsocyfc	325	37	et	et	NNP
cord-290566-tmsocyfc	325	38	al	al	NNP
cord-290566-tmsocyfc	325	39	.	.	NNP
cord-290566-tmsocyfc	325	40	,	,	,
cord-290566-tmsocyfc	325	41	1995	1995	CD
cord-290566-tmsocyfc	325	42	;	;	:
cord-290566-tmsocyfc	325	43	Zhang	Zhang	NNP
cord-290566-tmsocyfc	325	44	et	et	NNP
cord-290566-tmsocyfc	325	45	al	al	NNP
cord-290566-tmsocyfc	325	46	.	.	NNP
cord-290566-tmsocyfc	325	47	,	,	,
cord-290566-tmsocyfc	325	48	2002	2002	CD
cord-290566-tmsocyfc	325	49	)	)	-RRB-
cord-290566-tmsocyfc	325	50	.	.	.
cord-290566-tmsocyfc	326	1	In	in	IN
cord-290566-tmsocyfc	326	2	this	this	DT
cord-290566-tmsocyfc	326	3	study	study	NN
cord-290566-tmsocyfc	326	4	,	,	,
cord-290566-tmsocyfc	326	5	the	the	DT
cord-290566-tmsocyfc	326	6	frequency	frequency	NN
cord-290566-tmsocyfc	326	7	of	of	IN
cord-290566-tmsocyfc	326	8	gadolinium	gadolinium	NN
cord-290566-tmsocyfc	326	9	-	-	HYPH
cord-290566-tmsocyfc	326	10	enhancing	enhance	VBG
cord-290566-tmsocyfc	326	11	lesions	lesion	NNS
cord-290566-tmsocyfc	326	12	was	be	VBD
cord-290566-tmsocyfc	326	13	largely	largely	RB
cord-290566-tmsocyfc	326	14	unchanged	unchanged	JJ
cord-290566-tmsocyfc	326	15	posttreatment	posttreatment	NN
cord-290566-tmsocyfc	326	16	.	.	.
cord-290566-tmsocyfc	327	1	A	a	DT
cord-290566-tmsocyfc	327	2	second	second	JJ
cord-290566-tmsocyfc	327	3	pilot	pilot	NN
cord-290566-tmsocyfc	327	4	trial	trial	NN
cord-290566-tmsocyfc	327	5	using	use	VBG
cord-290566-tmsocyfc	327	6	autologous	autologous	JJ
cord-290566-tmsocyfc	327	7	MBP	MBP	NNP
cord-290566-tmsocyfc	327	8	and	and	CC
cord-290566-tmsocyfc	327	9	MOGreactive	MOGreactive	NNP
cord-290566-tmsocyfc	327	10	T	t	NN
cord-290566-tmsocyfc	327	11	-	-	HYPH
cord-290566-tmsocyfc	327	12	cell	cell	NN
cord-290566-tmsocyfc	327	13	vaccines	vaccine	NNS
cord-290566-tmsocyfc	327	14	in	in	IN
cord-290566-tmsocyfc	327	15	20	20	CD
cord-290566-tmsocyfc	327	16	RRMS	RRMS	NNP
cord-290566-tmsocyfc	327	17	nonresponders	nonresponder	NNS
cord-290566-tmsocyfc	327	18	demonstrated	demonstrate	VBD
cord-290566-tmsocyfc	327	19	a	a	DT
cord-290566-tmsocyfc	327	20	significant	significant	JJ
cord-290566-tmsocyfc	327	21	reduction	reduction	NN
cord-290566-tmsocyfc	327	22	in	in	IN
cord-290566-tmsocyfc	327	23	relapse	relapse	NN
cord-290566-tmsocyfc	327	24	rate	rate	NN
cord-290566-tmsocyfc	327	25	(	(	-LRB-
cord-290566-tmsocyfc	327	26	p	p	NN
cord-290566-tmsocyfc	327	27	¼	¼	CD
cord-290566-tmsocyfc	327	28	0.026	0.026	CD
cord-290566-tmsocyfc	327	29	)	)	-RRB-
cord-290566-tmsocyfc	327	30	as	as	RB
cord-290566-tmsocyfc	327	31	well	well	RB
cord-290566-tmsocyfc	327	32	as	as	IN
cord-290566-tmsocyfc	327	33	gadolinium	gadolinium	NN
cord-290566-tmsocyfc	327	34	enhancing	enhancing	NN
cord-290566-tmsocyfc	327	35	and	and	CC
cord-290566-tmsocyfc	327	36	T2	T2	NNP
cord-290566-tmsocyfc	327	37	lesion	lesion	NN
cord-290566-tmsocyfc	327	38	load	load	NN
cord-290566-tmsocyfc	328	1	(	(	-LRB-
cord-290566-tmsocyfc	328	2	Achiron	Achiron	NNP
cord-290566-tmsocyfc	328	3	et	et	NNP
cord-290566-tmsocyfc	328	4	al	al	NNP
cord-290566-tmsocyfc	328	5	.	.	NNP
cord-290566-tmsocyfc	328	6	,	,	,
cord-290566-tmsocyfc	328	7	2004	2004	CD
cord-290566-tmsocyfc	328	8	)	)	-RRB-
cord-290566-tmsocyfc	328	9	.	.	.
cord-290566-tmsocyfc	329	1	In	in	IN
cord-290566-tmsocyfc	329	2	both	both	DT
cord-290566-tmsocyfc	329	3	studies	study	NNS
cord-290566-tmsocyfc	329	4	,	,	,
cord-290566-tmsocyfc	329	5	no	no	DT
cord-290566-tmsocyfc	329	6	serious	serious	JJ
cord-290566-tmsocyfc	329	7	adverse	adverse	JJ
cord-290566-tmsocyfc	329	8	events	event	NNS
cord-290566-tmsocyfc	329	9	were	be	VBD
cord-290566-tmsocyfc	329	10	noted	note	VBN
cord-290566-tmsocyfc	329	11	.	.	.
cord-290566-tmsocyfc	330	1	In	in	IN
cord-290566-tmsocyfc	330	2	a	a	DT
cord-290566-tmsocyfc	330	3	small	small	JJ
cord-290566-tmsocyfc	330	4	study	study	NN
cord-290566-tmsocyfc	330	5	utilizing	utilize	VBG
cord-290566-tmsocyfc	330	6	myelin	myelin	NN
cord-290566-tmsocyfc	330	7	-	-	HYPH
cord-290566-tmsocyfc	330	8	reactive	reactive	JJ
cord-290566-tmsocyfc	330	9	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	330	10	T	T	NNP
cord-290566-tmsocyfc	330	11	cells	cell	NNS
cord-290566-tmsocyfc	330	12	derived	derive	VBN
cord-290566-tmsocyfc	330	13	from	from	IN
cord-290566-tmsocyfc	330	14	autologous	autologous	JJ
cord-290566-tmsocyfc	330	15	CSF	CSF	NNP
cord-290566-tmsocyfc	330	16	,	,	,
cord-290566-tmsocyfc	330	17	no	no	DT
cord-290566-tmsocyfc	330	18	adverse	adverse	JJ
cord-290566-tmsocyfc	330	19	eVects	eVects	NNPS
cord-290566-tmsocyfc	330	20	were	be	VBD
cord-290566-tmsocyfc	330	21	observed	observe	VBN
cord-290566-tmsocyfc	330	22	in	in	IN
cord-290566-tmsocyfc	330	23	any	any	DT
cord-290566-tmsocyfc	330	24	of	of	IN
cord-290566-tmsocyfc	330	25	the	the	DT
cord-290566-tmsocyfc	330	26	five	five	CD
cord-290566-tmsocyfc	330	27	treated	treat	VBN
cord-290566-tmsocyfc	330	28	patients	patient	NNS
cord-290566-tmsocyfc	330	29	(	(	-LRB-
cord-290566-tmsocyfc	330	30	Van	Van	NNP
cord-290566-tmsocyfc	330	31	der	der	NNP
cord-290566-tmsocyfc	330	32	Aa	Aa	NNP
cord-290566-tmsocyfc	330	33	et	et	FW
cord-290566-tmsocyfc	330	34	al	al	NNP
cord-290566-tmsocyfc	330	35	.	.	NNP
cord-290566-tmsocyfc	330	36	,	,	,
cord-290566-tmsocyfc	330	37	2003b	2003b	CD
cord-290566-tmsocyfc	330	38	)	)	-RRB-
cord-290566-tmsocyfc	330	39	.	.	.
cord-290566-tmsocyfc	331	1	Further	further	RB
cord-290566-tmsocyfc	331	2	larger	large	JJR
cord-290566-tmsocyfc	331	3	phase	phase	NN
cord-290566-tmsocyfc	331	4	II	ii	CD
cord-290566-tmsocyfc	331	5	trials	trial	NNS
cord-290566-tmsocyfc	331	6	using	use	VBG
cord-290566-tmsocyfc	331	7	T	t	NN
cord-290566-tmsocyfc	331	8	-	-	HYPH
cord-290566-tmsocyfc	331	9	cell	cell	NN
cord-290566-tmsocyfc	331	10	vaccination	vaccination	NN
cord-290566-tmsocyfc	331	11	are	be	VBP
cord-290566-tmsocyfc	331	12	planned	plan	VBN
cord-290566-tmsocyfc	331	13	.	.	.
cord-290566-tmsocyfc	332	1	TCR	TCR	NNP
cord-290566-tmsocyfc	332	2	vaccination	vaccination	NN
cord-290566-tmsocyfc	332	3	strategies	strategy	NNS
cord-290566-tmsocyfc	332	4	target	target	VBP
cord-290566-tmsocyfc	332	5	TCR	TCR	NNP
cord-290566-tmsocyfc	332	6	sequences	sequence	NNS
cord-290566-tmsocyfc	332	7	believed	believe	VBD
cord-290566-tmsocyfc	332	8	to	to	TO
cord-290566-tmsocyfc	332	9	be	be	VB
cord-290566-tmsocyfc	332	10	critical	critical	JJ
cord-290566-tmsocyfc	332	11	in	in	IN
cord-290566-tmsocyfc	332	12	the	the	DT
cord-290566-tmsocyfc	332	13	immunopathogenesis	immunopathogenesis	NN
cord-290566-tmsocyfc	332	14	of	of	IN
cord-290566-tmsocyfc	332	15	MS	MS	NNP
cord-290566-tmsocyfc	332	16	.	.	.
cord-290566-tmsocyfc	333	1	In	in	IN
cord-290566-tmsocyfc	333	2	MS	MS	NNP
cord-290566-tmsocyfc	333	3	,	,	,
cord-290566-tmsocyfc	333	4	V	v	NN
cord-290566-tmsocyfc	333	5	5.2/5.3þ	5.2/5.3þ	NN
cord-290566-tmsocyfc	333	6	has	have	VBZ
cord-290566-tmsocyfc	333	7	been	be	VBN
cord-290566-tmsocyfc	333	8	identified	identify	VBN
cord-290566-tmsocyfc	333	9	as	as	IN
cord-290566-tmsocyfc	333	10	a	a	DT
cord-290566-tmsocyfc	333	11	dominant	dominant	JJ
cord-290566-tmsocyfc	333	12	TCR	TCR	NNP
cord-290566-tmsocyfc	333	13	variable	variable	JJ
cord-290566-tmsocyfc	333	14	region	region	NN
cord-290566-tmsocyfc	333	15	sequence	sequence	NN
cord-290566-tmsocyfc	333	16	involved	involve	VBN
cord-290566-tmsocyfc	333	17	in	in	IN
cord-290566-tmsocyfc	333	18	MBP	MBP	NNP
cord-290566-tmsocyfc	333	19	T	T	NNP
cord-290566-tmsocyfc	333	20	-	-	HYPH
cord-290566-tmsocyfc	333	21	cell	cell	NN
cord-290566-tmsocyfc	333	22	reactivity	reactivity	NN
cord-290566-tmsocyfc	333	23	(	(	-LRB-
cord-290566-tmsocyfc	334	1	Kotzin	Kotzin	NNP
cord-290566-tmsocyfc	334	2	et	et	NNP
cord-290566-tmsocyfc	334	3	al	al	NNP
cord-290566-tmsocyfc	334	4	.	.	.
cord-290566-tmsocyfc	335	1	,	,	,
cord-290566-tmsocyfc	335	2	1991	1991	CD
cord-290566-tmsocyfc	335	3	;	;	:
cord-290566-tmsocyfc	335	4	Lozeron	Lozeron	NNP
cord-290566-tmsocyfc	335	5	et	et	FW
cord-290566-tmsocyfc	335	6	al	al	NNP
cord-290566-tmsocyfc	335	7	.	.	NNP
cord-290566-tmsocyfc	335	8	,	,	,
cord-290566-tmsocyfc	335	9	1998	1998	CD
cord-290566-tmsocyfc	335	10	;	;	:
cord-290566-tmsocyfc	335	11	Oksenberg	Oksenberg	NNP
cord-290566-tmsocyfc	335	12	et	et	NNP
cord-290566-tmsocyfc	335	13	al	al	NNP
cord-290566-tmsocyfc	335	14	.	.	NNP
cord-290566-tmsocyfc	335	15	,	,	,
cord-290566-tmsocyfc	335	16	1993	1993	CD
cord-290566-tmsocyfc	335	17	)	)	-RRB-
cord-290566-tmsocyfc	335	18	.	.	.
cord-290566-tmsocyfc	336	1	TCR	TCR	NNP
cord-290566-tmsocyfc	336	2	vaccines	vaccine	NNS
cord-290566-tmsocyfc	336	3	are	be	VBP
cord-290566-tmsocyfc	336	4	thought	think	VBN
cord-290566-tmsocyfc	336	5	to	to	TO
cord-290566-tmsocyfc	336	6	exert	exert	VB
cord-290566-tmsocyfc	336	7	their	-PRON-	PRP$
cord-290566-tmsocyfc	336	8	eVects	evect	NNS
cord-290566-tmsocyfc	336	9	by	by	IN
cord-290566-tmsocyfc	336	10	enhancing	enhance	VBG
cord-290566-tmsocyfc	336	11	the	the	DT
cord-290566-tmsocyfc	336	12	function	function	NN
cord-290566-tmsocyfc	336	13	of	of	IN
cord-290566-tmsocyfc	336	14	regulatory	regulatory	JJ
cord-290566-tmsocyfc	336	15	T	t	NN
cord-290566-tmsocyfc	336	16	-	-	HYPH
cord-290566-tmsocyfc	336	17	cell	cell	NN
cord-290566-tmsocyfc	336	18	populations	population	NNS
cord-290566-tmsocyfc	336	19	recognizing	recognize	VBG
cord-290566-tmsocyfc	336	20	TCR	TCR	NNP
cord-290566-tmsocyfc	336	21	determinants	determinant	NNS
cord-290566-tmsocyfc	336	22	(	(	-LRB-
cord-290566-tmsocyfc	336	23	Vandenbark	Vandenbark	NNP
cord-290566-tmsocyfc	336	24	,	,	,
cord-290566-tmsocyfc	336	25	2005	2005	CD
cord-290566-tmsocyfc	336	26	;	;	:
cord-290566-tmsocyfc	336	27	Vandenbark	Vandenbark	NNP
cord-290566-tmsocyfc	336	28	et	et	NNP
cord-290566-tmsocyfc	336	29	al	al	NNP
cord-290566-tmsocyfc	336	30	.	.	NNP
cord-290566-tmsocyfc	336	31	,	,	,
cord-290566-tmsocyfc	336	32	1996	1996	CD
cord-290566-tmsocyfc	336	33	)	)	-RRB-
cord-290566-tmsocyfc	336	34	.	.	.
cord-290566-tmsocyfc	337	1	TCR	TCR	NNP
cord-290566-tmsocyfc	337	2	peptides	peptide	NNS
cord-290566-tmsocyfc	337	3	derived	derive	VBN
cord-290566-tmsocyfc	337	4	from	from	IN
cord-290566-tmsocyfc	337	5	the	the	DT
cord-290566-tmsocyfc	337	6	V	v	NN
cord-290566-tmsocyfc	337	7	5.2	5.2	CD
cord-290566-tmsocyfc	337	8	region	region	NN
cord-290566-tmsocyfc	337	9	of	of	IN
cord-290566-tmsocyfc	337	10	the	the	DT
cord-290566-tmsocyfc	337	11	TCR	TCR	NNP
cord-290566-tmsocyfc	337	12	have	have	VBP
cord-290566-tmsocyfc	337	13	been	be	VBN
cord-290566-tmsocyfc	337	14	used	use	VBN
cord-290566-tmsocyfc	337	15	as	as	IN
cord-290566-tmsocyfc	337	16	a	a	DT
cord-290566-tmsocyfc	337	17	vaccine	vaccine	NN
cord-290566-tmsocyfc	337	18	in	in	IN
cord-290566-tmsocyfc	337	19	MS	MS	NNP
cord-290566-tmsocyfc	337	20	patients	patient	NNS
cord-290566-tmsocyfc	337	21	.	.	.
cord-290566-tmsocyfc	338	1	In	in	IN
cord-290566-tmsocyfc	338	2	a	a	DT
cord-290566-tmsocyfc	338	3	double	double	JJ
cord-290566-tmsocyfc	338	4	-	-	HYPH
cord-290566-tmsocyfc	338	5	blind	blind	JJ
cord-290566-tmsocyfc	338	6	pilot	pilot	NN
cord-290566-tmsocyfc	338	7	study	study	NN
cord-290566-tmsocyfc	338	8	,	,	,
cord-290566-tmsocyfc	338	9	23	23	CD
cord-290566-tmsocyfc	338	10	patients	patient	NNS
cord-290566-tmsocyfc	338	11	were	be	VBD
cord-290566-tmsocyfc	338	12	treated	treat	VBN
cord-290566-tmsocyfc	338	13	with	with	IN
cord-290566-tmsocyfc	338	14	weekly	weekly	NN
cord-290566-tmsocyfc	338	15	to	to	IN
cord-290566-tmsocyfc	338	16	monthly	monthly	JJ
cord-290566-tmsocyfc	338	17	injections	injection	NNS
cord-290566-tmsocyfc	338	18	of	of	IN
cord-290566-tmsocyfc	338	19	the	the	DT
cord-290566-tmsocyfc	338	20	peptide	peptide	NN
cord-290566-tmsocyfc	338	21	.	.	.
cord-290566-tmsocyfc	339	1	All	all	DT
cord-290566-tmsocyfc	339	2	patients	patient	NNS
cord-290566-tmsocyfc	339	3	carried	carry	VBD
cord-290566-tmsocyfc	339	4	the	the	DT
cord-290566-tmsocyfc	339	5	HLADRB1	HLADRB1	NNP
cord-290566-tmsocyfc	339	6	*	*	NFP
cord-290566-tmsocyfc	339	7	1501	1501	CD
cord-290566-tmsocyfc	339	8	allele	allele	NN
cord-290566-tmsocyfc	339	9	.	.	.
cord-290566-tmsocyfc	340	1	Enhanced	enhanced	JJ
cord-290566-tmsocyfc	340	2	T	t	NN
cord-290566-tmsocyfc	340	3	-	-	HYPH
cord-290566-tmsocyfc	340	4	cell	cell	NN
cord-290566-tmsocyfc	340	5	responses	response	NNS
cord-290566-tmsocyfc	340	6	to	to	IN
cord-290566-tmsocyfc	340	7	the	the	DT
cord-290566-tmsocyfc	340	8	immunizing	immunize	VBG
cord-290566-tmsocyfc	340	9	peptide	peptide	NN
cord-290566-tmsocyfc	340	10	correlated	correlate	VBN
cord-290566-tmsocyfc	340	11	with	with	IN
cord-290566-tmsocyfc	340	12	clinical	clinical	JJ
cord-290566-tmsocyfc	340	13	improvement	improvement	NN
cord-290566-tmsocyfc	340	14	(	(	-LRB-
cord-290566-tmsocyfc	340	15	Bourdette	Bourdette	NNP
cord-290566-tmsocyfc	340	16	et	et	NNP
cord-290566-tmsocyfc	340	17	al	al	NNP
cord-290566-tmsocyfc	340	18	.	.	.
cord-290566-tmsocyfc	341	1	,	,	,
cord-290566-tmsocyfc	341	2	1994	1994	CD
cord-290566-tmsocyfc	341	3	;	;	:
cord-290566-tmsocyfc	341	4	Vandenbark	Vandenbark	NNP
cord-290566-tmsocyfc	341	5	et	et	NNP
cord-290566-tmsocyfc	341	6	al	al	NNP
cord-290566-tmsocyfc	341	7	.	.	NNP
cord-290566-tmsocyfc	341	8	,	,	,
cord-290566-tmsocyfc	341	9	1996	1996	CD
cord-290566-tmsocyfc	341	10	)	)	-RRB-
cord-290566-tmsocyfc	341	11	.	.	.
cord-290566-tmsocyfc	342	1	T	t	NN
cord-290566-tmsocyfc	342	2	-	-	HYPH
cord-290566-tmsocyfc	342	3	cell	cell	NN
cord-290566-tmsocyfc	342	4	responses	response	NNS
cord-290566-tmsocyfc	342	5	to	to	IN
cord-290566-tmsocyfc	342	6	MBP	MBP	NNP
cord-290566-tmsocyfc	342	7	trended	trend	VBD
cord-290566-tmsocyfc	342	8	downward	downward	RB
cord-290566-tmsocyfc	342	9	in	in	IN
cord-290566-tmsocyfc	342	10	responders	responder	NNS
cord-290566-tmsocyfc	342	11	.	.	.
cord-290566-tmsocyfc	343	1	No	no	DT
cord-290566-tmsocyfc	343	2	major	major	JJ
cord-290566-tmsocyfc	343	3	adverse	adverse	JJ
cord-290566-tmsocyfc	343	4	events	event	NNS
cord-290566-tmsocyfc	343	5	were	be	VBD
cord-290566-tmsocyfc	343	6	observed	observe	VBN
cord-290566-tmsocyfc	343	7	in	in	IN
cord-290566-tmsocyfc	343	8	treated	treat	VBN
cord-290566-tmsocyfc	343	9	patients	patient	NNS
cord-290566-tmsocyfc	343	10	.	.	.
cord-290566-tmsocyfc	344	1	ATM-027	ATM-027	NNP
cord-290566-tmsocyfc	344	2	is	be	VBZ
cord-290566-tmsocyfc	344	3	an	an	DT
cord-290566-tmsocyfc	344	4	antibody	antibody	NN
cord-290566-tmsocyfc	344	5	specifically	specifically	RB
cord-290566-tmsocyfc	344	6	targeting	target	VBG
cord-290566-tmsocyfc	344	7	the	the	DT
cord-290566-tmsocyfc	344	8	V	v	NN
cord-290566-tmsocyfc	344	9	5.2/5.3	5.2/5.3	CD
cord-290566-tmsocyfc	344	10	sequence	sequence	NN
cord-290566-tmsocyfc	344	11	of	of	IN
cord-290566-tmsocyfc	344	12	TCR	TCR	NNP
cord-290566-tmsocyfc	344	13	.	.	.
cord-290566-tmsocyfc	345	1	Results	result	NNS
cord-290566-tmsocyfc	345	2	from	from	IN
cord-290566-tmsocyfc	345	3	a	a	DT
cord-290566-tmsocyfc	345	4	multicenter	multicenter	JJ
cord-290566-tmsocyfc	345	5	phase	phase	NN
cord-290566-tmsocyfc	345	6	II	ii	CD
cord-290566-tmsocyfc	345	7	study	study	NN
cord-290566-tmsocyfc	345	8	in	in	IN
cord-290566-tmsocyfc	345	9	47	47	CD
cord-290566-tmsocyfc	345	10	MS	MS	NNP
cord-290566-tmsocyfc	345	11	patients	patient	NNS
cord-290566-tmsocyfc	345	12	treated	treat	VBN
cord-290566-tmsocyfc	345	13	with	with	IN
cord-290566-tmsocyfc	345	14	a	a	DT
cord-290566-tmsocyfc	345	15	run	run	NN
cord-290566-tmsocyfc	345	16	-	-	HYPH
cord-290566-tmsocyfc	345	17	in	in	RP
cord-290566-tmsocyfc	345	18	regimen	regimen	NN
cord-290566-tmsocyfc	345	19	of	of	IN
cord-290566-tmsocyfc	345	20	ATM-027	atm-027	JJ
cord-290566-tmsocyfc	345	21	monthly	monthly	NN
cord-290566-tmsocyfc	345	22	for	for	IN
cord-290566-tmsocyfc	345	23	6	6	CD
cord-290566-tmsocyfc	345	24	months	month	NNS
cord-290566-tmsocyfc	345	25	,	,	,
cord-290566-tmsocyfc	345	26	showed	show	VBD
cord-290566-tmsocyfc	345	27	no	no	DT
cord-290566-tmsocyfc	345	28	significant	significant	JJ
cord-290566-tmsocyfc	345	29	reduction	reduction	NN
cord-290566-tmsocyfc	345	30	in	in	IN
cord-290566-tmsocyfc	345	31	new	new	JJ
cord-290566-tmsocyfc	345	32	gadolinium	gadolinium	NN
cord-290566-tmsocyfc	345	33	MRI	MRI	NNP
cord-290566-tmsocyfc	345	34	60	60	CD
cord-290566-tmsocyfc	345	35	TANUJA	TANUJA	NNP
cord-290566-tmsocyfc	345	36	CHITNIS	CHITNIS	NNP
cord-290566-tmsocyfc	345	37	lesions	lesion	NNS
cord-290566-tmsocyfc	345	38	posttreatment	posttreatment	NN
cord-290566-tmsocyfc	345	39	despite	despite	IN
cord-290566-tmsocyfc	345	40	a	a	DT
cord-290566-tmsocyfc	345	41	significant	significant	JJ
cord-290566-tmsocyfc	345	42	reduction	reduction	NN
cord-290566-tmsocyfc	345	43	in	in	IN
cord-290566-tmsocyfc	345	44	V	v	NN
cord-290566-tmsocyfc	345	45	5.2/5.3þ	5.2/5.3þ	NN
cord-290566-tmsocyfc	345	46	T	t	NN
cord-290566-tmsocyfc	345	47	cells	cell	NNS
cord-290566-tmsocyfc	345	48	Olsson	Olsson	NNP
cord-290566-tmsocyfc	345	49	et	et	NNP
cord-290566-tmsocyfc	345	50	al	al	NNP
cord-290566-tmsocyfc	345	51	.	.	NNP
cord-290566-tmsocyfc	345	52	,	,	,
cord-290566-tmsocyfc	345	53	2002	2002	CD
cord-290566-tmsocyfc	345	54	)	)	-RRB-
cord-290566-tmsocyfc	345	55	.	.	.
cord-290566-tmsocyfc	346	1	MS	MS	NNP
cord-290566-tmsocyfc	346	2	relapses	relapse	NNS
cord-290566-tmsocyfc	346	3	occurred	occur	VBD
cord-290566-tmsocyfc	346	4	in	in	IN
cord-290566-tmsocyfc	346	5	three	three	CD
cord-290566-tmsocyfc	346	6	treated	treat	VBN
cord-290566-tmsocyfc	346	7	patients	patient	NNS
cord-290566-tmsocyfc	346	8	,	,	,
cord-290566-tmsocyfc	346	9	however	however	RB
cord-290566-tmsocyfc	346	10	no	no	DT
cord-290566-tmsocyfc	346	11	other	other	JJ
cord-290566-tmsocyfc	346	12	adverse	adverse	JJ
cord-290566-tmsocyfc	346	13	events	event	NNS
cord-290566-tmsocyfc	346	14	directly	directly	RB
cord-290566-tmsocyfc	346	15	related	relate	VBN
cord-290566-tmsocyfc	346	16	to	to	IN
cord-290566-tmsocyfc	346	17	drug	drug	NN
cord-290566-tmsocyfc	346	18	were	be	VBD
cord-290566-tmsocyfc	346	19	observed	observe	VBN
cord-290566-tmsocyfc	346	20	.	.	.
cord-290566-tmsocyfc	347	1	These	these	DT
cord-290566-tmsocyfc	347	2	negative	negative	JJ
cord-290566-tmsocyfc	347	3	results	result	NNS
cord-290566-tmsocyfc	347	4	suggest	suggest	VBP
cord-290566-tmsocyfc	347	5	that	that	IN
cord-290566-tmsocyfc	347	6	there	there	EX
cord-290566-tmsocyfc	347	7	is	be	VBZ
cord-290566-tmsocyfc	347	8	considerable	considerable	JJ
cord-290566-tmsocyfc	347	9	variability	variability	NN
cord-290566-tmsocyfc	347	10	in	in	IN
cord-290566-tmsocyfc	347	11	V	v	NN
cord-290566-tmsocyfc	347	12	profiling	profiling	NN
cord-290566-tmsocyfc	347	13	in	in	IN
cord-290566-tmsocyfc	347	14	individual	individual	JJ
cord-290566-tmsocyfc	347	15	MS	MS	NNP
cord-290566-tmsocyfc	347	16	patients	patient	NNS
cord-290566-tmsocyfc	347	17	.	.	.
cord-290566-tmsocyfc	348	1	An	an	DT
cord-290566-tmsocyfc	348	2	alternative	alternative	JJ
cord-290566-tmsocyfc	348	3	explanation	explanation	NN
cord-290566-tmsocyfc	348	4	is	be	VBZ
cord-290566-tmsocyfc	348	5	that	that	IN
cord-290566-tmsocyfc	348	6	by	by	IN
cord-290566-tmsocyfc	348	7	the	the	DT
cord-290566-tmsocyfc	348	8	time	time	NN
cord-290566-tmsocyfc	348	9	the	the	DT
cord-290566-tmsocyfc	348	10	disease	disease	NN
cord-290566-tmsocyfc	348	11	presents	present	VBZ
cord-290566-tmsocyfc	348	12	clinically	clinically	RB
cord-290566-tmsocyfc	348	13	,	,	,
cord-290566-tmsocyfc	348	14	epitope	epitope	NN
cord-290566-tmsocyfc	348	15	spreading	spreading	NN
cord-290566-tmsocyfc	348	16	has	have	VBZ
cord-290566-tmsocyfc	348	17	occurred	occur	VBN
cord-290566-tmsocyfc	348	18	,	,	,
cord-290566-tmsocyfc	348	19	negating	negate	VBG
cord-290566-tmsocyfc	348	20	the	the	DT
cord-290566-tmsocyfc	348	21	use	use	NN
cord-290566-tmsocyfc	348	22	of	of	IN
cord-290566-tmsocyfc	348	23	a	a	DT
cord-290566-tmsocyfc	348	24	single	single	JJ
cord-290566-tmsocyfc	348	25	V	v	NN
cord-290566-tmsocyfc	348	26	-	-	HYPH
cord-290566-tmsocyfc	348	27	depleting	deplete	VBG
cord-290566-tmsocyfc	348	28	agent	agent	NN
cord-290566-tmsocyfc	348	29	.	.	.
cord-290566-tmsocyfc	349	1	CD4	CD4	NNP
cord-290566-tmsocyfc	349	2	is	be	VBZ
cord-290566-tmsocyfc	349	3	a	a	DT
cord-290566-tmsocyfc	349	4	cell	cell	NN
cord-290566-tmsocyfc	349	5	-	-	HYPH
cord-290566-tmsocyfc	349	6	surface	surface	NN
cord-290566-tmsocyfc	349	7	marker	marker	NN
cord-290566-tmsocyfc	349	8	of	of	IN
cord-290566-tmsocyfc	349	9	Th	Th	NNP
cord-290566-tmsocyfc	349	10	cells	cell	NNS
cord-290566-tmsocyfc	349	11	.	.	.
cord-290566-tmsocyfc	350	1	In	in	IN
cord-290566-tmsocyfc	350	2	a	a	DT
cord-290566-tmsocyfc	350	3	randomized	randomized	JJ
cord-290566-tmsocyfc	350	4	phase	phase	NN
cord-290566-tmsocyfc	350	5	II	II	NNP
cord-290566-tmsocyfc	350	6	doubleblind	doubleblind	NN
cord-290566-tmsocyfc	350	7	trial	trial	NN
cord-290566-tmsocyfc	350	8	,	,	,
cord-290566-tmsocyfc	350	9	an	an	DT
cord-290566-tmsocyfc	350	10	anti	anti	JJ
cord-290566-tmsocyfc	350	11	-	-	JJ
cord-290566-tmsocyfc	350	12	CD4	cd4	JJ
cord-290566-tmsocyfc	350	13	antibody	antibody	NN
cord-290566-tmsocyfc	350	14	(	(	-LRB-
cord-290566-tmsocyfc	350	15	cM	cM	NNP
cord-290566-tmsocyfc	350	16	-	-	HYPH
cord-290566-tmsocyfc	350	17	T412	T412	NNP
cord-290566-tmsocyfc	350	18	)	)	-RRB-
cord-290566-tmsocyfc	350	19	was	be	VBD
cord-290566-tmsocyfc	350	20	administered	administer	VBN
cord-290566-tmsocyfc	350	21	intravenously	intravenously	RB
cord-290566-tmsocyfc	350	22	to	to	IN
cord-290566-tmsocyfc	350	23	35	35	CD
cord-290566-tmsocyfc	350	24	RRMS	rrm	NNS
cord-290566-tmsocyfc	350	25	and	and	CC
cord-290566-tmsocyfc	350	26	SPMS	SPMS	NNP
cord-290566-tmsocyfc	350	27	patients	patient	NNS
cord-290566-tmsocyfc	350	28	(	(	-LRB-
cord-290566-tmsocyfc	350	29	van	van	NNP
cord-290566-tmsocyfc	350	30	Oosten	Oosten	NNP
cord-290566-tmsocyfc	350	31	et	et	NNP
cord-290566-tmsocyfc	350	32	al	al	NNP
cord-290566-tmsocyfc	350	33	.	.	NNP
cord-290566-tmsocyfc	350	34	,	,	,
cord-290566-tmsocyfc	350	35	1997	1997	CD
cord-290566-tmsocyfc	350	36	)	)	-RRB-
cord-290566-tmsocyfc	350	37	.	.	.
cord-290566-tmsocyfc	351	1	Administration	administration	NN
cord-290566-tmsocyfc	351	2	of	of	IN
cord-290566-tmsocyfc	351	3	the	the	DT
cord-290566-tmsocyfc	351	4	antibody	antibody	NN
cord-290566-tmsocyfc	351	5	resulted	result	VBD
cord-290566-tmsocyfc	351	6	in	in	IN
cord-290566-tmsocyfc	351	7	a	a	DT
cord-290566-tmsocyfc	351	8	rapid	rapid	JJ
cord-290566-tmsocyfc	351	9	and	and	CC
cord-290566-tmsocyfc	351	10	sustained	sustained	JJ
cord-290566-tmsocyfc	351	11	reduction	reduction	NN
cord-290566-tmsocyfc	351	12	in	in	IN
cord-290566-tmsocyfc	351	13	circulating	circulate	VBG
cord-290566-tmsocyfc	351	14	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	351	15	T	T	NNP
cord-290566-tmsocyfc	351	16	cells	cell	NNS
cord-290566-tmsocyfc	351	17	.	.	.
cord-290566-tmsocyfc	352	1	Infusion	infusion	NN
cord-290566-tmsocyfc	352	2	-	-	HYPH
cord-290566-tmsocyfc	352	3	related	relate	VBN
cord-290566-tmsocyfc	352	4	side	side	NN
cord-290566-tmsocyfc	352	5	eVects	evect	NNS
cord-290566-tmsocyfc	352	6	including	include	VBG
cord-290566-tmsocyfc	352	7	nausea	nausea	NN
cord-290566-tmsocyfc	352	8	,	,	,
cord-290566-tmsocyfc	352	9	fever	fever	NN
cord-290566-tmsocyfc	352	10	,	,	,
cord-290566-tmsocyfc	352	11	and	and	CC
cord-290566-tmsocyfc	352	12	tachycardia	tachycardia	NN
cord-290566-tmsocyfc	352	13	were	be	VBD
cord-290566-tmsocyfc	352	14	limited	limit	VBN
cord-290566-tmsocyfc	352	15	to	to	IN
cord-290566-tmsocyfc	352	16	24-h	24-h	JJ
cord-290566-tmsocyfc	352	17	postinfusion	postinfusion	NN
cord-290566-tmsocyfc	352	18	.	.	.
cord-290566-tmsocyfc	353	1	After	after	IN
cord-290566-tmsocyfc	353	2	9	9	CD
cord-290566-tmsocyfc	353	3	months	month	NNS
cord-290566-tmsocyfc	353	4	,	,	,
cord-290566-tmsocyfc	353	5	treated	treat	VBN
cord-290566-tmsocyfc	353	6	patients	patient	NNS
cord-290566-tmsocyfc	353	7	demonstrated	demonstrate	VBD
cord-290566-tmsocyfc	353	8	an	an	DT
cord-290566-tmsocyfc	353	9	approximately	approximately	RB
cord-290566-tmsocyfc	353	10	40	40	CD
cord-290566-tmsocyfc	353	11	%	%	NN
cord-290566-tmsocyfc	353	12	reduction	reduction	NN
cord-290566-tmsocyfc	353	13	in	in	IN
cord-290566-tmsocyfc	353	14	relapse	relapse	NN
cord-290566-tmsocyfc	353	15	rate	rate	NN
cord-290566-tmsocyfc	353	16	compared	compare	VBN
cord-290566-tmsocyfc	353	17	to	to	IN
cord-290566-tmsocyfc	353	18	placebo	placebo	NN
cord-290566-tmsocyfc	353	19	controls	control	NNS
cord-290566-tmsocyfc	353	20	,	,	,
cord-290566-tmsocyfc	353	21	however	however	RB
cord-290566-tmsocyfc	353	22	there	there	EX
cord-290566-tmsocyfc	353	23	was	be	VBD
cord-290566-tmsocyfc	353	24	no	no	DT
cord-290566-tmsocyfc	353	25	significant	significant	JJ
cord-290566-tmsocyfc	353	26	change	change	NN
cord-290566-tmsocyfc	353	27	in	in	IN
cord-290566-tmsocyfc	353	28	the	the	DT
cord-290566-tmsocyfc	353	29	number	number	NN
cord-290566-tmsocyfc	353	30	of	of	IN
cord-290566-tmsocyfc	353	31	gadolinium	gadolinium	NN
cord-290566-tmsocyfc	353	32	-	-	HYPH
cord-290566-tmsocyfc	353	33	enhancing	enhance	VBG
cord-290566-tmsocyfc	353	34	lesions	lesion	NNS
cord-290566-tmsocyfc	353	35	on	on	IN
cord-290566-tmsocyfc	353	36	MRI	MRI	NNP
cord-290566-tmsocyfc	353	37	.	.	.
cord-290566-tmsocyfc	354	1	Although	although	IN
cord-290566-tmsocyfc	354	2	anti	anti	JJ
cord-290566-tmsocyfc	354	3	-	-	JJ
cord-290566-tmsocyfc	354	4	CD4	cd4	JJ
cord-290566-tmsocyfc	354	5	therapy	therapy	NN
cord-290566-tmsocyfc	354	6	was	be	VBD
cord-290566-tmsocyfc	354	7	eVective	eVective	NNP
cord-290566-tmsocyfc	354	8	in	in	IN
cord-290566-tmsocyfc	354	9	reducing	reduce	VBG
cord-290566-tmsocyfc	354	10	relapse	relapse	NN
cord-290566-tmsocyfc	354	11	rate	rate	NN
cord-290566-tmsocyfc	354	12	,	,	,
cord-290566-tmsocyfc	354	13	lack	lack	NN
cord-290566-tmsocyfc	354	14	of	of	IN
cord-290566-tmsocyfc	354	15	eYcacy	eYcacy	NNP
cord-290566-tmsocyfc	354	16	on	on	IN
cord-290566-tmsocyfc	354	17	primary	primary	JJ
cord-290566-tmsocyfc	354	18	MRI	MRI	NNP
cord-290566-tmsocyfc	354	19	measures	measure	NNS
cord-290566-tmsocyfc	354	20	has	have	VBZ
cord-290566-tmsocyfc	354	21	led	lead	VBN
cord-290566-tmsocyfc	354	22	to	to	IN
cord-290566-tmsocyfc	354	23	questions	question	NNS
cord-290566-tmsocyfc	354	24	regarding	regard	VBG
cord-290566-tmsocyfc	354	25	the	the	DT
cord-290566-tmsocyfc	354	26	eVectiveness	eVectiveness	NNP
cord-290566-tmsocyfc	354	27	in	in	IN
cord-290566-tmsocyfc	354	28	MS	MS	NNP
cord-290566-tmsocyfc	354	29	.	.	.
cord-290566-tmsocyfc	355	1	The	the	DT
cord-290566-tmsocyfc	355	2	Jak	Jak	NNP
cord-290566-tmsocyfc	355	3	/	/	SYM
cord-290566-tmsocyfc	355	4	STAT	stat	NN
cord-290566-tmsocyfc	355	5	family	family	NN
cord-290566-tmsocyfc	355	6	of	of	IN
cord-290566-tmsocyfc	355	7	transducer	transducer	NN
cord-290566-tmsocyfc	355	8	/	/	SYM
cord-290566-tmsocyfc	355	9	transcription	transcription	NN
cord-290566-tmsocyfc	355	10	-	-	HYPH
cord-290566-tmsocyfc	355	11	activating	activate	VBG
cord-290566-tmsocyfc	355	12	factors	factor	NNS
cord-290566-tmsocyfc	355	13	plays	play	VBZ
cord-290566-tmsocyfc	355	14	a	a	DT
cord-290566-tmsocyfc	355	15	critical	critical	JJ
cord-290566-tmsocyfc	355	16	role	role	NN
cord-290566-tmsocyfc	355	17	in	in	IN
cord-290566-tmsocyfc	355	18	the	the	DT
cord-290566-tmsocyfc	355	19	signaling	signaling	NN
cord-290566-tmsocyfc	355	20	of	of	IN
cord-290566-tmsocyfc	355	21	many	many	JJ
cord-290566-tmsocyfc	355	22	cytokine	cytokine	JJ
cord-290566-tmsocyfc	355	23	receptors	receptor	NNS
cord-290566-tmsocyfc	355	24	.	.	.
cord-290566-tmsocyfc	356	1	3-Hydroxy-3-methylglutaryl	3-hydroxy-3-methylglutaryl	CD
cord-290566-tmsocyfc	357	1	coenzyme	coenzyme	NNP
cord-290566-tmsocyfc	357	2	A	a	DT
cord-290566-tmsocyfc	357	3	(	(	-LRB-
cord-290566-tmsocyfc	357	4	HMG	HMG	NNP
cord-290566-tmsocyfc	357	5	-	-	HYPH
cord-290566-tmsocyfc	357	6	CoA	CoA	NNP
cord-290566-tmsocyfc	357	7	)	)	-RRB-
cord-290566-tmsocyfc	358	1	reductase	reductase	NN
cord-290566-tmsocyfc	358	2	inhibitors	inhibitor	NNS
cord-290566-tmsocyfc	358	3	such	such	JJ
cord-290566-tmsocyfc	358	4	as	as	IN
cord-290566-tmsocyfc	358	5	atorvastatin	atorvastatin	NNP
cord-290566-tmsocyfc	358	6	has	have	VBZ
cord-290566-tmsocyfc	358	7	been	be	VBN
cord-290566-tmsocyfc	358	8	shown	show	VBN
cord-290566-tmsocyfc	358	9	to	to	TO
cord-290566-tmsocyfc	358	10	exert	exert	VB
cord-290566-tmsocyfc	358	11	its	-PRON-	PRP$
cord-290566-tmsocyfc	358	12	protective	protective	JJ
cord-290566-tmsocyfc	358	13	eVects	evect	NNS
cord-290566-tmsocyfc	358	14	in	in	IN
cord-290566-tmsocyfc	358	15	EAE	EAE	NNP
cord-290566-tmsocyfc	358	16	through	through	IN
cord-290566-tmsocyfc	358	17	the	the	DT
cord-290566-tmsocyfc	358	18	induction	induction	NN
cord-290566-tmsocyfc	358	19	of	of	IN
cord-290566-tmsocyfc	358	20	STAT6	stat6	NN
cord-290566-tmsocyfc	358	21	phosphorylation	phosphorylation	NN
cord-290566-tmsocyfc	358	22	and	and	CC
cord-290566-tmsocyfc	358	23	secretion	secretion	NN
cord-290566-tmsocyfc	358	24	of	of	IN
cord-290566-tmsocyfc	358	25	Th2	th2	CD
cord-290566-tmsocyfc	358	26	cytokines	cytokine	NNS
cord-290566-tmsocyfc	358	27	,	,	,
cord-290566-tmsocyfc	358	28	with	with	IN
cord-290566-tmsocyfc	358	29	concomitant	concomitant	JJ
cord-290566-tmsocyfc	358	30	inhibition	inhibition	NN
cord-290566-tmsocyfc	358	31	of	of	IN
cord-290566-tmsocyfc	358	32	STAT4	stat4	NN
cord-290566-tmsocyfc	358	33	phosphorylation	phosphorylation	NN
cord-290566-tmsocyfc	358	34	and	and	CC
cord-290566-tmsocyfc	358	35	secretion	secretion	NN
cord-290566-tmsocyfc	358	36	of	of	IN
cord-290566-tmsocyfc	358	37	Th1	th1	NN
cord-290566-tmsocyfc	358	38	cytokines	cytokine	NNS
cord-290566-tmsocyfc	358	39	(	(	-LRB-
cord-290566-tmsocyfc	359	1	Youssef	Youssef	NNP
cord-290566-tmsocyfc	359	2	et	et	NNP
cord-290566-tmsocyfc	359	3	al	al	NNP
cord-290566-tmsocyfc	359	4	.	.	NNP
cord-290566-tmsocyfc	359	5	,	,	,
cord-290566-tmsocyfc	359	6	2002	2002	CD
cord-290566-tmsocyfc	359	7	)	)	-RRB-
cord-290566-tmsocyfc	359	8	.	.	.
cord-290566-tmsocyfc	360	1	A	a	DT
cord-290566-tmsocyfc	360	2	pilot	pilot	NN
cord-290566-tmsocyfc	360	3	clinical	clinical	JJ
cord-290566-tmsocyfc	360	4	trial	trial	NN
cord-290566-tmsocyfc	360	5	of	of	IN
cord-290566-tmsocyfc	360	6	simvastatin	simvastatin	NN
cord-290566-tmsocyfc	360	7	in	in	IN
cord-290566-tmsocyfc	360	8	MS	MS	NNP
cord-290566-tmsocyfc	360	9	showed	show	VBD
cord-290566-tmsocyfc	360	10	positive	positive	JJ
cord-290566-tmsocyfc	360	11	results	result	NNS
cord-290566-tmsocyfc	360	12	and	and	CC
cord-290566-tmsocyfc	360	13	a	a	DT
cord-290566-tmsocyfc	360	14	larger	large	JJR
cord-290566-tmsocyfc	360	15	trial	trial	NN
cord-290566-tmsocyfc	360	16	of	of	IN
cord-290566-tmsocyfc	360	17	Atorvastatin	Atorvastatin	NNP
cord-290566-tmsocyfc	360	18	is	be	VBZ
cord-290566-tmsocyfc	360	19	under	under	IN
cord-290566-tmsocyfc	360	20	way	way	NN
cord-290566-tmsocyfc	360	21	.	.	.
cord-290566-tmsocyfc	361	1	Inhibition	inhibition	NN
cord-290566-tmsocyfc	361	2	of	of	IN
cord-290566-tmsocyfc	361	3	molecular	molecular	JJ
cord-290566-tmsocyfc	361	4	pathways	pathway	NNS
cord-290566-tmsocyfc	361	5	involved	involve	VBN
cord-290566-tmsocyfc	361	6	in	in	IN
cord-290566-tmsocyfc	361	7	T	t	NN
cord-290566-tmsocyfc	361	8	-	-	HYPH
cord-290566-tmsocyfc	361	9	cell	cell	NN
cord-290566-tmsocyfc	361	10	migration	migration	NN
cord-290566-tmsocyfc	361	11	has	have	VBZ
cord-290566-tmsocyfc	361	12	been	be	VBN
cord-290566-tmsocyfc	361	13	eVective	eVective	NNP
cord-290566-tmsocyfc	361	14	in	in	IN
cord-290566-tmsocyfc	361	15	reducing	reduce	VBG
cord-290566-tmsocyfc	361	16	MS	MS	NNP
cord-290566-tmsocyfc	361	17	relapses	relapse	NNS
cord-290566-tmsocyfc	361	18	(	(	-LRB-
cord-290566-tmsocyfc	361	19	Miller	Miller	NNP
cord-290566-tmsocyfc	361	20	et	et	NNP
cord-290566-tmsocyfc	361	21	al	al	NNP
cord-290566-tmsocyfc	361	22	.	.	NNP
cord-290566-tmsocyfc	361	23	,	,	,
cord-290566-tmsocyfc	361	24	2003	2003	CD
cord-290566-tmsocyfc	361	25	)	)	-RRB-
cord-290566-tmsocyfc	361	26	,	,	,
cord-290566-tmsocyfc	361	27	however	however	WRB
cord-290566-tmsocyfc	361	28	clinical	clinical	JJ
cord-290566-tmsocyfc	361	29	trials	trial	NNS
cord-290566-tmsocyfc	361	30	with	with	IN
cord-290566-tmsocyfc	361	31	an	an	DT
cord-290566-tmsocyfc	361	32	4-integrin	4-integrin	CD
cord-290566-tmsocyfc	361	33	antibody	antibody	NN
cord-290566-tmsocyfc	361	34	led	lead	VBD
cord-290566-tmsocyfc	361	35	to	to	IN
cord-290566-tmsocyfc	361	36	several	several	JJ
cord-290566-tmsocyfc	361	37	cases	case	NNS
cord-290566-tmsocyfc	361	38	of	of	IN
cord-290566-tmsocyfc	361	39	progressive	progressive	JJ
cord-290566-tmsocyfc	361	40	multifocal	multifocal	JJ
cord-290566-tmsocyfc	361	41	leukoencephalopathy	leukoencephalopathy	NNS
cord-290566-tmsocyfc	361	42	,	,	,
cord-290566-tmsocyfc	361	43	resulting	result	VBG
cord-290566-tmsocyfc	361	44	in	in	IN
cord-290566-tmsocyfc	361	45	the	the	DT
cord-290566-tmsocyfc	361	46	reevaluation	reevaluation	NN
cord-290566-tmsocyfc	361	47	of	of	IN
cord-290566-tmsocyfc	361	48	the	the	DT
cord-290566-tmsocyfc	361	49	role	role	NN
cord-290566-tmsocyfc	361	50	of	of	IN
cord-290566-tmsocyfc	361	51	such	such	JJ
cord-290566-tmsocyfc	361	52	drugs	drug	NNS
cord-290566-tmsocyfc	361	53	in	in	IN
cord-290566-tmsocyfc	361	54	MS	MS	NNP
cord-290566-tmsocyfc	361	55	therapeutics	therapeutic	NNS
cord-290566-tmsocyfc	361	56	(	(	-LRB-
cord-290566-tmsocyfc	361	57	Kleinschmidt	Kleinschmidt	NNP
cord-290566-tmsocyfc	361	58	-	-	HYPH
cord-290566-tmsocyfc	361	59	Demasters	Demasters	NNPS
cord-290566-tmsocyfc	361	60	and	and	CC
cord-290566-tmsocyfc	361	61	Tyler	Tyler	NNP
cord-290566-tmsocyfc	361	62	,	,	,
cord-290566-tmsocyfc	361	63	2005	2005	CD
cord-290566-tmsocyfc	361	64	;	;	:
cord-290566-tmsocyfc	361	65	Langer	Langer	NNP
cord-290566-tmsocyfc	361	66	-	-	HYPH
cord-290566-tmsocyfc	361	67	Gould	Gould	NNP
cord-290566-tmsocyfc	361	68	et	et	NNP
cord-290566-tmsocyfc	361	69	al	al	NNP
cord-290566-tmsocyfc	361	70	.	.	.
cord-290566-tmsocyfc	362	1	,	,	,
cord-290566-tmsocyfc	362	2	2005	2005	CD
cord-290566-tmsocyfc	362	3	;	;	:
cord-290566-tmsocyfc	362	4	Van	Van	NNP
cord-290566-tmsocyfc	362	5	Assche	Assche	NNP
cord-290566-tmsocyfc	362	6	et	et	NNP
cord-290566-tmsocyfc	362	7	al	al	NNP
cord-290566-tmsocyfc	362	8	.	.	NNP
cord-290566-tmsocyfc	362	9	,	,	,
cord-290566-tmsocyfc	362	10	2005	2005	CD
cord-290566-tmsocyfc	362	11	)	)	-RRB-
cord-290566-tmsocyfc	362	12	.	.	.
cord-290566-tmsocyfc	363	1	In	in	IN
cord-290566-tmsocyfc	363	2	conclusion	conclusion	NN
cord-290566-tmsocyfc	363	3	,	,	,
cord-290566-tmsocyfc	363	4	we	-PRON-	PRP
cord-290566-tmsocyfc	363	5	have	have	VBP
cord-290566-tmsocyfc	363	6	summarized	summarize	VBN
cord-290566-tmsocyfc	363	7	the	the	DT
cord-290566-tmsocyfc	363	8	evidence	evidence	NN
cord-290566-tmsocyfc	363	9	for	for	IN
cord-290566-tmsocyfc	363	10	the	the	DT
cord-290566-tmsocyfc	363	11	central	central	JJ
cord-290566-tmsocyfc	363	12	role	role	NN
cord-290566-tmsocyfc	363	13	of	of	IN
cord-290566-tmsocyfc	363	14	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	363	15	T	T	NNP
cord-290566-tmsocyfc	363	16	cells	cell	NNS
cord-290566-tmsocyfc	363	17	in	in	IN
cord-290566-tmsocyfc	363	18	the	the	DT
cord-290566-tmsocyfc	363	19	pathogenesis	pathogenesis	NN
cord-290566-tmsocyfc	363	20	of	of	IN
cord-290566-tmsocyfc	363	21	MS	MS	NNP
cord-290566-tmsocyfc	363	22	,	,	,
cord-290566-tmsocyfc	363	23	which	which	WDT
cord-290566-tmsocyfc	363	24	represents	represent	VBZ
cord-290566-tmsocyfc	363	25	the	the	DT
cord-290566-tmsocyfc	363	26	work	work	NN
cord-290566-tmsocyfc	363	27	of	of	IN
cord-290566-tmsocyfc	363	28	many	many	JJ
cord-290566-tmsocyfc	363	29	teams	team	NNS
cord-290566-tmsocyfc	363	30	of	of	IN
cord-290566-tmsocyfc	363	31	investigators	investigator	NNS
cord-290566-tmsocyfc	363	32	over	over	IN
cord-290566-tmsocyfc	363	33	many	many	JJ
cord-290566-tmsocyfc	363	34	years	year	NNS
cord-290566-tmsocyfc	363	35	.	.	.
cord-290566-tmsocyfc	364	1	Although	although	IN
cord-290566-tmsocyfc	364	2	much	much	JJ
cord-290566-tmsocyfc	364	3	progress	progress	NN
cord-290566-tmsocyfc	364	4	has	have	VBZ
cord-290566-tmsocyfc	364	5	been	be	VBN
cord-290566-tmsocyfc	364	6	made	make	VBN
cord-290566-tmsocyfc	364	7	in	in	IN
cord-290566-tmsocyfc	364	8	the	the	DT
cord-290566-tmsocyfc	364	9	field	field	NN
cord-290566-tmsocyfc	364	10	,	,	,
cord-290566-tmsocyfc	364	11	which	which	WDT
cord-290566-tmsocyfc	364	12	has	have	VBZ
cord-290566-tmsocyfc	364	13	led	lead	VBN
cord-290566-tmsocyfc	364	14	to	to	IN
cord-290566-tmsocyfc	364	15	important	important	JJ
cord-290566-tmsocyfc	364	16	therapeutic	therapeutic	JJ
cord-290566-tmsocyfc	364	17	advances	advance	NNS
cord-290566-tmsocyfc	364	18	,	,	,
cord-290566-tmsocyfc	364	19	several	several	JJ
cord-290566-tmsocyfc	364	20	questions	question	NNS
cord-290566-tmsocyfc	364	21	remain	remain	VBP
cord-290566-tmsocyfc	364	22	unanswered	unanswered	JJ
cord-290566-tmsocyfc	364	23	,	,	,
cord-290566-tmsocyfc	364	24	including	include	VBG
cord-290566-tmsocyfc	364	25	the	the	DT
cord-290566-tmsocyfc	364	26	nature	nature	NN
cord-290566-tmsocyfc	364	27	of	of	IN
cord-290566-tmsocyfc	364	28	the	the	DT
cord-290566-tmsocyfc	364	29	initiating	initiate	VBG
cord-290566-tmsocyfc	364	30	T	t	NN
cord-290566-tmsocyfc	364	31	-	-	HYPH
cord-290566-tmsocyfc	364	32	cell	cell	NN
cord-290566-tmsocyfc	364	33	responses	response	NNS
cord-290566-tmsocyfc	364	34	and	and	CC
cord-290566-tmsocyfc	364	35	THE	the	DT
cord-290566-tmsocyfc	364	36	ROLE	role	NN
cord-290566-tmsocyfc	364	37	OF	of	IN
cord-290566-tmsocyfc	364	38	CD4	CD4	NNP
cord-290566-tmsocyfc	364	39	T	T	NNP
cord-290566-tmsocyfc	364	40	CELLS	cell	VBN
cord-290566-tmsocyfc	364	41	IN	in	IN
cord-290566-tmsocyfc	364	42	THE	the	DT
cord-290566-tmsocyfc	364	43	PATHOGENESIS	PATHOGENESIS	NNP
cord-290566-tmsocyfc	364	44	the	the	DT
cord-290566-tmsocyfc	364	45	mechanisms	mechanism	NNS
cord-290566-tmsocyfc	364	46	of	of	IN
cord-290566-tmsocyfc	364	47	propagation	propagation	NN
cord-290566-tmsocyfc	364	48	of	of	IN
cord-290566-tmsocyfc	364	49	the	the	DT
cord-290566-tmsocyfc	364	50	disease	disease	NN
cord-290566-tmsocyfc	364	51	within	within	IN
cord-290566-tmsocyfc	364	52	the	the	DT
cord-290566-tmsocyfc	364	53	CNS	CNS	NNP
cord-290566-tmsocyfc	364	54	.	.	.
cord-290566-tmsocyfc	365	1	The	the	DT
cord-290566-tmsocyfc	365	2	field	field	NN
cord-290566-tmsocyfc	365	3	of	of	IN
cord-290566-tmsocyfc	365	4	T	t	NN
cord-290566-tmsocyfc	365	5	-	-	HYPH
cord-290566-tmsocyfc	365	6	cell	cell	NN
cord-290566-tmsocyfc	365	7	biology	biology	NN
cord-290566-tmsocyfc	365	8	remains	remain	VBZ
cord-290566-tmsocyfc	365	9	an	an	DT
cord-290566-tmsocyfc	365	10	integral	integral	JJ
cord-290566-tmsocyfc	365	11	part	part	NN
cord-290566-tmsocyfc	365	12	of	of	IN
cord-290566-tmsocyfc	365	13	the	the	DT
cord-290566-tmsocyfc	365	14	MS	MS	NNP
cord-290566-tmsocyfc	365	15	question	question	NN
cord-290566-tmsocyfc	365	16	,	,	,
cord-290566-tmsocyfc	365	17	and	and	CC
cord-290566-tmsocyfc	365	18	further	further	JJ
cord-290566-tmsocyfc	365	19	advances	advance	NNS
cord-290566-tmsocyfc	365	20	will	will	MD
cord-290566-tmsocyfc	365	21	undoubtedly	undoubtedly	RB
cord-290566-tmsocyfc	365	22	lead	lead	VB
cord-290566-tmsocyfc	365	23	to	to	IN
cord-290566-tmsocyfc	365	24	improved	improve	VBN
cord-290566-tmsocyfc	365	25	treatment	treatment	NN
cord-290566-tmsocyfc	365	26	strategies	strategy	NNS
cord-290566-tmsocyfc	365	27	for	for	IN
cord-290566-tmsocyfc	365	28	patients	patient	NNS
cord-290566-tmsocyfc	365	29	.	.	.
cord-290566-tmsocyfc	366	1	T	T	NNP
cord-290566-tmsocyfc	366	2	cell	cell	NN
cord-290566-tmsocyfc	366	3	vaccination	vaccination	NN
cord-290566-tmsocyfc	366	4	in	in	IN
cord-290566-tmsocyfc	366	5	multiple	multiple	JJ
cord-290566-tmsocyfc	366	6	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	366	7	relapsing	relapse	VBG
cord-290566-tmsocyfc	366	8	-	-	HYPH
cord-290566-tmsocyfc	366	9	remitting	remit	VBG
cord-290566-tmsocyfc	366	10	nonresponders	nonresponder	NNS
cord-290566-tmsocyfc	366	11	patients	patient	NNS
cord-290566-tmsocyfc	367	1	Interleukin-23	Interleukin-23	NNP
cord-290566-tmsocyfc	367	2	promotes	promote	VBZ
cord-290566-tmsocyfc	367	3	a	a	DT
cord-290566-tmsocyfc	367	4	distinct	distinct	JJ
cord-290566-tmsocyfc	367	5	CD4	CD4	NNP
cord-290566-tmsocyfc	367	6	T	T	NNP
cord-290566-tmsocyfc	367	7	cell	cell	NN
cord-290566-tmsocyfc	367	8	activation	activation	NN
cord-290566-tmsocyfc	367	9	state	state	NN
cord-290566-tmsocyfc	367	10	characterized	characterize	VBN
cord-290566-tmsocyfc	367	11	by	by	IN
cord-290566-tmsocyfc	367	12	the	the	DT
cord-290566-tmsocyfc	367	13	production	production	NN
cord-290566-tmsocyfc	367	14	of	of	IN
cord-290566-tmsocyfc	367	15	interleukin-17	interleukin-17	NN
cord-290566-tmsocyfc	367	16	Copolymer	Copolymer	NNP
cord-290566-tmsocyfc	367	17	1	1	CD
cord-290566-tmsocyfc	367	18	acts	act	NNS
cord-290566-tmsocyfc	367	19	against	against	IN
cord-290566-tmsocyfc	367	20	the	the	DT
cord-290566-tmsocyfc	367	21	immunodominant	immunodominant	JJ
cord-290566-tmsocyfc	367	22	epitope	epitope	NNP
cord-290566-tmsocyfc	367	23	82	82	CD
cord-290566-tmsocyfc	367	24	-	-	SYM
cord-290566-tmsocyfc	367	25	100	100	CD
cord-290566-tmsocyfc	367	26	of	of	IN
cord-290566-tmsocyfc	367	27	myelin	myelin	JJ
cord-290566-tmsocyfc	367	28	basic	basic	JJ
cord-290566-tmsocyfc	367	29	protein	protein	NN
cord-290566-tmsocyfc	367	30	by	by	IN
cord-290566-tmsocyfc	367	31	T	T	NNP
cord-290566-tmsocyfc	367	32	cell	cell	NN
cord-290566-tmsocyfc	367	33	receptor	receptor	NN
cord-290566-tmsocyfc	367	34	antagonism	antagonism	NN
cord-290566-tmsocyfc	367	35	in	in	IN
cord-290566-tmsocyfc	367	36	addition	addition	NN
cord-290566-tmsocyfc	367	37	to	to	IN
cord-290566-tmsocyfc	367	38	major	major	JJ
cord-290566-tmsocyfc	367	39	histocompatibility	histocompatibility	NN
cord-290566-tmsocyfc	367	40	complex	complex	NN
cord-290566-tmsocyfc	367	41	blocking	block	VBG
cord-290566-tmsocyfc	367	42	Specific	specific	JJ
cord-290566-tmsocyfc	367	43	Th2	th2	CD
cord-290566-tmsocyfc	367	44	cells	cell	NNS
cord-290566-tmsocyfc	367	45	accumulate	accumulate	VBP
cord-290566-tmsocyfc	367	46	in	in	IN
cord-290566-tmsocyfc	367	47	the	the	DT
cord-290566-tmsocyfc	367	48	central	central	JJ
cord-290566-tmsocyfc	367	49	nervous	nervous	JJ
cord-290566-tmsocyfc	367	50	system	system	NN
cord-290566-tmsocyfc	367	51	of	of	IN
cord-290566-tmsocyfc	367	52	mice	mouse	NNS
cord-290566-tmsocyfc	367	53	protected	protect	VBN
cord-290566-tmsocyfc	367	54	against	against	IN
cord-290566-tmsocyfc	367	55	experimental	experimental	JJ
cord-290566-tmsocyfc	367	56	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	367	57	encephalomyelitis	encephalomyelitis	NN
cord-290566-tmsocyfc	367	58	by	by	IN
cord-290566-tmsocyfc	367	59	copolymer	copolymer	NN
cord-290566-tmsocyfc	367	60	1	1	CD
cord-290566-tmsocyfc	367	61	Oral	oral	JJ
cord-290566-tmsocyfc	367	62	treatment	treatment	NN
cord-290566-tmsocyfc	367	63	of	of	IN
cord-290566-tmsocyfc	367	64	mice	mouse	NNS
cord-290566-tmsocyfc	367	65	with	with	IN
cord-290566-tmsocyfc	367	66	copolymer	copolymer	NN
cord-290566-tmsocyfc	367	67	1	1	CD
cord-290566-tmsocyfc	368	1	(	(	-LRB-
cord-290566-tmsocyfc	368	2	glatiramer	glatiramer	NNP
cord-290566-tmsocyfc	368	3	acetate	acetate	NNP
cord-290566-tmsocyfc	368	4	)	)	-RRB-
cord-290566-tmsocyfc	368	5	results	result	NNS
cord-290566-tmsocyfc	368	6	in	in	IN
cord-290566-tmsocyfc	368	7	the	the	DT
cord-290566-tmsocyfc	368	8	accumulation	accumulation	NN
cord-290566-tmsocyfc	368	9	of	of	IN
cord-290566-tmsocyfc	368	10	specific	specific	JJ
cord-290566-tmsocyfc	368	11	Th2	th2	CD
cord-290566-tmsocyfc	368	12	cells	cell	NNS
cord-290566-tmsocyfc	368	13	in	in	IN
cord-290566-tmsocyfc	368	14	the	the	DT
cord-290566-tmsocyfc	368	15	central	central	JJ
cord-290566-tmsocyfc	368	16	nervous	nervous	JJ
cord-290566-tmsocyfc	368	17	system	system	NN
cord-290566-tmsocyfc	369	1	Glatiramer	glatiramer	JJ
cord-290566-tmsocyfc	369	2	acetate	acetate	NN
cord-290566-tmsocyfc	369	3	-	-	HYPH
cord-290566-tmsocyfc	369	4	specific	specific	JJ
cord-290566-tmsocyfc	369	5	T	t	NN
cord-290566-tmsocyfc	369	6	cells	cell	NNS
cord-290566-tmsocyfc	369	7	in	in	IN
cord-290566-tmsocyfc	369	8	the	the	DT
cord-290566-tmsocyfc	369	9	brain	brain	NN
cord-290566-tmsocyfc	369	10	express	express	VBP
cord-290566-tmsocyfc	369	11	T	T	NNP
cord-290566-tmsocyfc	369	12	helper	helper	NN
cord-290566-tmsocyfc	369	13	2/3	2/3	CD
cord-290566-tmsocyfc	369	14	cytokines	cytokine	NNS
cord-290566-tmsocyfc	369	15	and	and	CC
cord-290566-tmsocyfc	369	16	brain	brain	NN
cord-290566-tmsocyfc	369	17	-	-	HYPH
cord-290566-tmsocyfc	369	18	derived	derive	VBN
cord-290566-tmsocyfc	369	19	neurotrophic	neurotrophic	NN
cord-290566-tmsocyfc	369	20	factor	factor	NN
cord-290566-tmsocyfc	369	21	in	in	IN
cord-290566-tmsocyfc	369	22	situ	situ	JJ
cord-290566-tmsocyfc	369	23	T	t	NN
cord-290566-tmsocyfc	369	24	-	-	HYPH
cord-290566-tmsocyfc	369	25	cell	cell	NN
cord-290566-tmsocyfc	369	26	regulation	regulation	NN
cord-290566-tmsocyfc	369	27	by	by	IN
cord-290566-tmsocyfc	369	28	CD28	CD28	NNP
cord-290566-tmsocyfc	369	29	and	and	CC
cord-290566-tmsocyfc	369	30	CTLA-4	CTLA-4	NNP
cord-290566-tmsocyfc	369	31	T	T	NNP
cord-290566-tmsocyfc	369	32	cells	cell	NNS
cord-290566-tmsocyfc	369	33	responsive	responsive	JJ
cord-290566-tmsocyfc	369	34	to	to	IN
cord-290566-tmsocyfc	369	35	myelin	myelin	JJ
cord-290566-tmsocyfc	369	36	basic	basic	JJ
cord-290566-tmsocyfc	369	37	protein	protein	NN
cord-290566-tmsocyfc	369	38	in	in	IN
cord-290566-tmsocyfc	369	39	patients	patient	NNS
cord-290566-tmsocyfc	369	40	with	with	IN
cord-290566-tmsocyfc	369	41	multiple	multiple	JJ
cord-290566-tmsocyfc	369	42	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	369	43	High	high	JJ
cord-290566-tmsocyfc	369	44	levels	level	NNS
cord-290566-tmsocyfc	369	45	of	of	IN
cord-290566-tmsocyfc	369	46	interleukin	interleukin	NN
cord-290566-tmsocyfc	369	47	10	10	CD
cord-290566-tmsocyfc	369	48	production	production	NN
cord-290566-tmsocyfc	369	49	in	in	IN
cord-290566-tmsocyfc	369	50	vivo	vivo	NN
cord-290566-tmsocyfc	369	51	are	be	VBP
cord-290566-tmsocyfc	369	52	associated	associate	VBN
cord-290566-tmsocyfc	369	53	with	with	IN
cord-290566-tmsocyfc	369	54	tolerance	tolerance	NN
cord-290566-tmsocyfc	369	55	in	in	IN
cord-290566-tmsocyfc	369	56	SCID	SCID	NNP
cord-290566-tmsocyfc	369	57	patients	patient	NNS
cord-290566-tmsocyfc	369	58	transplanted	transplant	VBN
cord-290566-tmsocyfc	369	59	with	with	IN
cord-290566-tmsocyfc	369	60	HLA	HLA	NNP
cord-290566-tmsocyfc	369	61	mismatched	mismatch	VBN
cord-290566-tmsocyfc	369	62	hematopoietic	hematopoietic	JJ
cord-290566-tmsocyfc	369	63	stem	stem	NN
cord-290566-tmsocyfc	369	64	cells	cell	NNS
cord-290566-tmsocyfc	369	65	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	369	66	CD25	CD25	NNP
cord-290566-tmsocyfc	369	67	high	high	JJ
cord-290566-tmsocyfc	369	68	regulatory	regulatory	JJ
cord-290566-tmsocyfc	369	69	cells	cell	NNS
cord-290566-tmsocyfc	369	70	in	in	IN
cord-290566-tmsocyfc	369	71	human	human	JJ
cord-290566-tmsocyfc	369	72	peripheral	peripheral	JJ
cord-290566-tmsocyfc	369	73	blood	blood	NN
cord-290566-tmsocyfc	369	74	Increased	increase	VBN
cord-290566-tmsocyfc	369	75	interleukin	interleukin	NN
cord-290566-tmsocyfc	369	76	12	12	CD
cord-290566-tmsocyfc	369	77	production	production	NN
cord-290566-tmsocyfc	369	78	in	in	IN
cord-290566-tmsocyfc	369	79	progressive	progressive	JJ
cord-290566-tmsocyfc	369	80	multiple	multiple	JJ
cord-290566-tmsocyfc	369	81	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	369	82	:	:	:
cord-290566-tmsocyfc	370	1	Induction	induction	NN
cord-290566-tmsocyfc	370	2	by	by	IN
cord-290566-tmsocyfc	370	3	activated	activate	VBN
cord-290566-tmsocyfc	370	4	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	370	5	T	T	NNP
cord-290566-tmsocyfc	370	6	cells	cell	NNS
cord-290566-tmsocyfc	370	7	via	via	IN
cord-290566-tmsocyfc	370	8	CD40	CD40	NNP
cord-290566-tmsocyfc	370	9	ligand	ligand	NN
cord-290566-tmsocyfc	370	10	Seasonal	seasonal	JJ
cord-290566-tmsocyfc	370	11	variation	variation	NN
cord-290566-tmsocyfc	370	12	of	of	IN
cord-290566-tmsocyfc	370	13	interferon	interferon	NN
cord-290566-tmsocyfc	370	14	-	-	HYPH
cord-290566-tmsocyfc	370	15	gamma	gamma	NN
cord-290566-tmsocyfc	370	16	production	production	NN
cord-290566-tmsocyfc	370	17	in	in	IN
cord-290566-tmsocyfc	370	18	progressive	progressive	JJ
cord-290566-tmsocyfc	370	19	multiple	multiple	JJ
cord-290566-tmsocyfc	370	20	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	370	21	Defective	defective	JJ
cord-290566-tmsocyfc	370	22	regulation	regulation	NN
cord-290566-tmsocyfc	370	23	of	of	IN
cord-290566-tmsocyfc	370	24	IFN	IFN	NNP
cord-290566-tmsocyfc	370	25	and	and	CC
cord-290566-tmsocyfc	371	1	IL-12	IL-12	NNP
cord-290566-tmsocyfc	371	2	by	by	IN
cord-290566-tmsocyfc	371	3	endogenous	endogenous	JJ
cord-290566-tmsocyfc	371	4	IL-10	IL-10	NNP
cord-290566-tmsocyfc	371	5	in	in	IN
cord-290566-tmsocyfc	371	6	progressive	progressive	JJ
cord-290566-tmsocyfc	371	7	MS	MS	NNP
cord-290566-tmsocyfc	371	8	Interferongamma	Interferongamma	NNP
cord-290566-tmsocyfc	371	9	secretion	secretion	NN
cord-290566-tmsocyfc	371	10	by	by	IN
cord-290566-tmsocyfc	371	11	peripheral	peripheral	JJ
cord-290566-tmsocyfc	371	12	blood	blood	NN
cord-290566-tmsocyfc	371	13	T	t	NN
cord-290566-tmsocyfc	371	14	-	-	HYPH
cord-290566-tmsocyfc	371	15	cell	cell	NN
cord-290566-tmsocyfc	371	16	subsets	subset	NNS
cord-290566-tmsocyfc	371	17	in	in	IN
cord-290566-tmsocyfc	371	18	multiple	multiple	JJ
cord-290566-tmsocyfc	371	19	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	371	20	:	:	:
cord-290566-tmsocyfc	371	21	Correlation	correlation	NN
cord-290566-tmsocyfc	371	22	with	with	IN
cord-290566-tmsocyfc	371	23	disease	disease	NN
cord-290566-tmsocyfc	371	24	phase	phase	NN
cord-290566-tmsocyfc	371	25	and	and	CC
cord-290566-tmsocyfc	371	26	interferon	interferon	NN
cord-290566-tmsocyfc	371	27	-	-	HYPH
cord-290566-tmsocyfc	371	28	beta	beta	NN
cord-290566-tmsocyfc	371	29	therapy	therapy	NN
cord-290566-tmsocyfc	371	30	Increased	increase	VBN
cord-290566-tmsocyfc	371	31	production	production	NN
cord-290566-tmsocyfc	371	32	of	of	IN
cord-290566-tmsocyfc	371	33	interferon	interferon	NN
cord-290566-tmsocyfc	371	34	gamma	gamma	NN
cord-290566-tmsocyfc	371	35	and	and	CC
cord-290566-tmsocyfc	371	36	tumor	tumor	NN
cord-290566-tmsocyfc	371	37	necrosis	necrosis	NN
cord-290566-tmsocyfc	371	38	factor	factor	NN
cord-290566-tmsocyfc	371	39	precedes	precede	VBZ
cord-290566-tmsocyfc	371	40	clinical	clinical	JJ
cord-290566-tmsocyfc	371	41	manifestation	manifestation	NN
cord-290566-tmsocyfc	371	42	in	in	IN
cord-290566-tmsocyfc	371	43	multiple	multiple	JJ
cord-290566-tmsocyfc	371	44	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	371	45	:	:	:
cord-290566-tmsocyfc	372	1	Do	do	VBP
cord-290566-tmsocyfc	372	2	cytokines	cytokine	NNS
cord-290566-tmsocyfc	372	3	trigger	trigger	VB
cord-290566-tmsocyfc	372	4	oV	ov	IN
cord-290566-tmsocyfc	372	5	exacerbations	exacerbation	NNS
cord-290566-tmsocyfc	372	6	?	?	.
cord-290566-tmsocyfc	373	1	IL-10	IL-10	NNP
cord-290566-tmsocyfc	373	2	is	be	VBZ
cord-290566-tmsocyfc	373	3	critical	critical	JJ
cord-290566-tmsocyfc	373	4	in	in	IN
cord-290566-tmsocyfc	373	5	the	the	DT
cord-290566-tmsocyfc	373	6	regulation	regulation	NN
cord-290566-tmsocyfc	373	7	of	of	IN
cord-290566-tmsocyfc	373	8	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	373	9	encephalomyelitis	encephalomyelitis	NN
cord-290566-tmsocyfc	373	10	as	as	IN
cord-290566-tmsocyfc	373	11	demonstrated	demonstrate	VBN
cord-290566-tmsocyfc	373	12	by	by	IN
cord-290566-tmsocyfc	373	13	studies	study	NNS
cord-290566-tmsocyfc	373	14	of	of	IN
cord-290566-tmsocyfc	373	15	IL-10-and	il-10-and	CD
cord-290566-tmsocyfc	373	16	IL-4-deficient	il-4-deficient	NN
cord-290566-tmsocyfc	373	17	and	and	CC
cord-290566-tmsocyfc	373	18	transgenic	transgenic	JJ
cord-290566-tmsocyfc	373	19	mice	mouse	NNS
cord-290566-tmsocyfc	373	20	Reciprocal	reciprocal	JJ
cord-290566-tmsocyfc	373	21	developmental	developmental	JJ
cord-290566-tmsocyfc	373	22	pathways	pathway	NNS
cord-290566-tmsocyfc	373	23	for	for	IN
cord-290566-tmsocyfc	373	24	the	the	DT
cord-290566-tmsocyfc	373	25	generation	generation	NN
cord-290566-tmsocyfc	373	26	of	of	IN
cord-290566-tmsocyfc	373	27	pathogenic	pathogenic	JJ
cord-290566-tmsocyfc	373	28	eVector	eVector	NNP
cord-290566-tmsocyfc	373	29	TH17	TH17	NNP
cord-290566-tmsocyfc	373	30	and	and	CC
cord-290566-tmsocyfc	373	31	regulatory	regulatory	JJ
cord-290566-tmsocyfc	373	32	T	t	NN
cord-290566-tmsocyfc	373	33	cells	cell	NNS
cord-290566-tmsocyfc	373	34	Antigen	antigen	NN
cord-290566-tmsocyfc	373	35	-	-	HYPH
cord-290566-tmsocyfc	373	36	specific	specific	JJ
cord-290566-tmsocyfc	373	37	immunomodulation	immunomodulation	NN
cord-290566-tmsocyfc	373	38	via	via	IN
cord-290566-tmsocyfc	373	39	altered	altered	JJ
cord-290566-tmsocyfc	373	40	peptide	peptide	NN
cord-290566-tmsocyfc	373	41	ligands	ligand	NNS
cord-290566-tmsocyfc	373	42	Encephalitogenic	Encephalitogenic	NNP
cord-290566-tmsocyfc	373	43	potential	potential	NN
cord-290566-tmsocyfc	373	44	of	of	IN
cord-290566-tmsocyfc	373	45	the	the	DT
cord-290566-tmsocyfc	373	46	myelin	myelin	JJ
cord-290566-tmsocyfc	373	47	basic	basic	JJ
cord-290566-tmsocyfc	373	48	protein	protein	NN
cord-290566-tmsocyfc	373	49	peptide	peptide	NN
cord-290566-tmsocyfc	373	50	(	(	-LRB-
cord-290566-tmsocyfc	373	51	amino	amino	JJ
cord-290566-tmsocyfc	373	52	acids	acid	NNS
cord-290566-tmsocyfc	373	53	83	83	CD
cord-290566-tmsocyfc	373	54	-	-	SYM
cord-290566-tmsocyfc	373	55	99	99	CD
cord-290566-tmsocyfc	373	56	)	)	-RRB-
cord-290566-tmsocyfc	373	57	in	in	IN
cord-290566-tmsocyfc	373	58	multiple	multiple	JJ
cord-290566-tmsocyfc	373	59	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	373	60	:	:	:
cord-290566-tmsocyfc	373	61	Results	result	NNS
cord-290566-tmsocyfc	373	62	of	of	IN
cord-290566-tmsocyfc	373	63	a	a	DT
cord-290566-tmsocyfc	373	64	phase	phase	NN
cord-290566-tmsocyfc	373	65	II	ii	CD
cord-290566-tmsocyfc	373	66	clinical	clinical	JJ
cord-290566-tmsocyfc	373	67	trial	trial	NN
cord-290566-tmsocyfc	373	68	with	with	IN
cord-290566-tmsocyfc	373	69	an	an	DT
cord-290566-tmsocyfc	373	70	altered	altered	JJ
cord-290566-tmsocyfc	373	71	peptide	peptide	NN
cord-290566-tmsocyfc	373	72	ligand	ligand	NN
cord-290566-tmsocyfc	373	73	Helper	helper	NN
cord-290566-tmsocyfc	373	74	T	t	NN
cord-290566-tmsocyfc	373	75	cell	cell	NN
cord-290566-tmsocyfc	373	76	diVerentiation	diverentiation	NN
cord-290566-tmsocyfc	373	77	is	be	VBZ
cord-290566-tmsocyfc	373	78	controlled	control	VBN
cord-290566-tmsocyfc	373	79	by	by	IN
cord-290566-tmsocyfc	373	80	the	the	DT
cord-290566-tmsocyfc	373	81	cell	cell	NN
cord-290566-tmsocyfc	373	82	cycle	cycle	NN
cord-290566-tmsocyfc	373	83	Acute	acute	JJ
cord-290566-tmsocyfc	373	84	axonal	axonal	JJ
cord-290566-tmsocyfc	373	85	injury	injury	NN
cord-290566-tmsocyfc	373	86	in	in	IN
cord-290566-tmsocyfc	373	87	multiple	multiple	JJ
cord-290566-tmsocyfc	373	88	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	373	89	.	.	.
cord-290566-tmsocyfc	374	1	Correlation	correlation	NN
cord-290566-tmsocyfc	374	2	with	with	IN
cord-290566-tmsocyfc	374	3	demyelination	demyelination	NN
cord-290566-tmsocyfc	374	4	and	and	CC
cord-290566-tmsocyfc	374	5	inflammation	inflammation	NN
cord-290566-tmsocyfc	374	6	Distribution	distribution	NN
cord-290566-tmsocyfc	374	7	of	of	IN
cord-290566-tmsocyfc	374	8	immunoglobulin	immunoglobulin	NN
cord-290566-tmsocyfc	374	9	superfamily	superfamily	NN
cord-290566-tmsocyfc	374	10	members	member	NNS
cord-290566-tmsocyfc	374	11	ICAM-1	ICAM-1	NNP
cord-290566-tmsocyfc	374	12	,	,	,
cord-290566-tmsocyfc	374	13	-2	-2	NNP
cord-290566-tmsocyfc	374	14	,	,	,
cord-290566-tmsocyfc	374	15	-3	-3	NNP
cord-290566-tmsocyfc	374	16	,	,	,
cord-290566-tmsocyfc	374	17	and	and	CC
cord-290566-tmsocyfc	374	18	the	the	DT
cord-290566-tmsocyfc	374	19	beta	beta	JJ
cord-290566-tmsocyfc	374	20	2	2	CD
cord-290566-tmsocyfc	374	21	integrin	integrin	NN
cord-290566-tmsocyfc	374	22	LFA-1	LFA-1	NNP
cord-290566-tmsocyfc	374	23	in	in	IN
cord-290566-tmsocyfc	374	24	multiple	multiple	JJ
cord-290566-tmsocyfc	374	25	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	374	26	lesions	lesion	NNS
cord-290566-tmsocyfc	374	27	Immunity	Immunity	NNP
cord-290566-tmsocyfc	374	28	to	to	IN
cord-290566-tmsocyfc	374	29	TCR	TCR	NNP
cord-290566-tmsocyfc	374	30	peptides	peptide	NNS
cord-290566-tmsocyfc	374	31	in	in	IN
cord-290566-tmsocyfc	374	32	multiple	multiple	JJ
cord-290566-tmsocyfc	374	33	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	374	34	.	.	.
cord-290566-tmsocyfc	375	1	I.	I.	NNP
cord-290566-tmsocyfc	375	2	Successful	successful	JJ
cord-290566-tmsocyfc	375	3	immunization	immunization	NN
cord-290566-tmsocyfc	375	4	of	of	IN
cord-290566-tmsocyfc	375	5	patients	patient	NNS
cord-290566-tmsocyfc	375	6	with	with	IN
cord-290566-tmsocyfc	375	7	synthetic	synthetic	JJ
cord-290566-tmsocyfc	375	8	V	v	NN
cord-290566-tmsocyfc	375	9	5.2	5.2	CD
cord-290566-tmsocyfc	375	10	and	and	CC
cord-290566-tmsocyfc	375	11	V	V	NNP
cord-290566-tmsocyfc	375	12	6.1	6.1	CD
cord-290566-tmsocyfc	375	13	CDR2	CDR2	NNP
cord-290566-tmsocyfc	375	14	peptides	peptide	NNS
cord-290566-tmsocyfc	376	1	A	a	DT
cord-290566-tmsocyfc	376	2	theory	theory	NN
cord-290566-tmsocyfc	376	3	of	of	IN
cord-290566-tmsocyfc	376	4	self	self	NN
cord-290566-tmsocyfc	376	5	-	-	HYPH
cord-290566-tmsocyfc	376	6	nonself	nonself	NN
cord-290566-tmsocyfc	376	7	discrimination	discrimination	NN
cord-290566-tmsocyfc	377	1	A	a	DT
cord-290566-tmsocyfc	377	2	two	two	CD
cord-290566-tmsocyfc	377	3	-	-	HYPH
cord-290566-tmsocyfc	377	4	step	step	NN
cord-290566-tmsocyfc	377	5	,	,	,
cord-290566-tmsocyfc	377	6	two	two	CD
cord-290566-tmsocyfc	377	7	-	-	HYPH
cord-290566-tmsocyfc	377	8	signal	signal	NN
cord-290566-tmsocyfc	377	9	model	model	NN
cord-290566-tmsocyfc	377	10	for	for	IN
cord-290566-tmsocyfc	377	11	the	the	DT
cord-290566-tmsocyfc	377	12	primary	primary	JJ
cord-290566-tmsocyfc	377	13	activation	activation	NN
cord-290566-tmsocyfc	377	14	of	of	IN
cord-290566-tmsocyfc	377	15	precursor	precursor	NN
cord-290566-tmsocyfc	377	16	helper	helper	NN
cord-290566-tmsocyfc	377	17	T	t	NN
cord-290566-tmsocyfc	377	18	cells	cell	NNS
cord-290566-tmsocyfc	378	1	A	a	DT
cord-290566-tmsocyfc	378	2	new	new	JJ
cord-290566-tmsocyfc	378	3	member	member	NN
cord-290566-tmsocyfc	378	4	of	of	IN
cord-290566-tmsocyfc	378	5	the	the	DT
cord-290566-tmsocyfc	378	6	immunoglobulin	immunoglobulin	NN
cord-290566-tmsocyfc	378	7	superfamily	superfamily	NN
cord-290566-tmsocyfc	378	8	-	-	HYPH
cord-290566-tmsocyfc	378	9	CTLA-4	CTLA-4	NNS
cord-290566-tmsocyfc	378	10	DiVerential	DiVerential	NNP
cord-290566-tmsocyfc	378	11	activation	activation	NN
cord-290566-tmsocyfc	378	12	requirements	requirement	NNS
cord-290566-tmsocyfc	378	13	for	for	IN
cord-290566-tmsocyfc	378	14	virgin	virgin	NN
cord-290566-tmsocyfc	378	15	and	and	CC
cord-290566-tmsocyfc	378	16	memory	memory	NN
cord-290566-tmsocyfc	378	17	T	t	NN
cord-290566-tmsocyfc	378	18	cells	cell	NNS
cord-290566-tmsocyfc	379	1	The	the	DT
cord-290566-tmsocyfc	379	2	adhesion	adhesion	NN
cord-290566-tmsocyfc	379	3	molecule	molecule	NN
cord-290566-tmsocyfc	379	4	and	and	CC
cord-290566-tmsocyfc	379	5	cytokine	cytokine	NN
cord-290566-tmsocyfc	379	6	profile	profile	NN
cord-290566-tmsocyfc	379	7	of	of	IN
cord-290566-tmsocyfc	379	8	multiple	multiple	JJ
cord-290566-tmsocyfc	379	9	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	379	10	lesions	lesion	NNS
cord-290566-tmsocyfc	379	11	Tim-2	Tim-2	NNP
cord-290566-tmsocyfc	379	12	regulates	regulate	VBZ
cord-290566-tmsocyfc	379	13	T	T	NNP
cord-290566-tmsocyfc	379	14	helper	helper	NN
cord-290566-tmsocyfc	379	15	type	type	NN
cord-290566-tmsocyfc	379	16	2	2	CD
cord-290566-tmsocyfc	379	17	responses	response	NNS
cord-290566-tmsocyfc	379	18	and	and	CC
cord-290566-tmsocyfc	379	19	autoimmunity	autoimmunity	NN
cord-290566-tmsocyfc	380	1	Selective	selective	JJ
cord-290566-tmsocyfc	380	2	regulatory	regulatory	JJ
cord-290566-tmsocyfc	380	3	function	function	NN
cord-290566-tmsocyfc	380	4	of	of	IN
cord-290566-tmsocyfc	380	5	Socs3	Socs3	NNP
cord-290566-tmsocyfc	380	6	in	in	IN
cord-290566-tmsocyfc	380	7	the	the	DT
cord-290566-tmsocyfc	380	8	formation	formation	NN
cord-290566-tmsocyfc	380	9	of	of	IN
cord-290566-tmsocyfc	380	10	IL-17-secreting	IL-17-secreting	NNP
cord-290566-tmsocyfc	380	11	T	T	NNP
cord-290566-tmsocyfc	380	12	cells	cell	NNS
cord-290566-tmsocyfc	380	13	Cytokine	cytokine	NN
cord-290566-tmsocyfc	380	14	shifts	shift	NNS
cord-290566-tmsocyfc	380	15	and	and	CC
cord-290566-tmsocyfc	380	16	tolerance	tolerance	NN
cord-290566-tmsocyfc	380	17	in	in	IN
cord-290566-tmsocyfc	380	18	experimental	experimental	JJ
cord-290566-tmsocyfc	380	19	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	380	20	encephalomyelitis	encephalomyelitis	NN
cord-290566-tmsocyfc	380	21	Role	role	NN
cord-290566-tmsocyfc	380	22	of	of	IN
cord-290566-tmsocyfc	380	23	costimulatory	costimulatory	NNP
cord-290566-tmsocyfc	380	24	pathways	pathway	NNS
cord-290566-tmsocyfc	380	25	in	in	IN
cord-290566-tmsocyfc	380	26	the	the	DT
cord-290566-tmsocyfc	380	27	pathogenesis	pathogenesis	NN
cord-290566-tmsocyfc	380	28	of	of	IN
cord-290566-tmsocyfc	380	29	multiple	multiple	JJ
cord-290566-tmsocyfc	380	30	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	380	31	and	and	CC
cord-290566-tmsocyfc	380	32	experimental	experimental	JJ
cord-290566-tmsocyfc	380	33	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	380	34	encephalomyelitis	encephalomyelitis	NN
cord-290566-tmsocyfc	381	1	CD28-independent	cd28-independent	CD
cord-290566-tmsocyfc	381	2	induction	induction	NN
cord-290566-tmsocyfc	381	3	of	of	IN
cord-290566-tmsocyfc	381	4	experimental	experimental	JJ
cord-290566-tmsocyfc	381	5	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	381	6	encephalomyelitis	encephalomyelitis	NN
cord-290566-tmsocyfc	381	7	EVect	EVect	NNP
cord-290566-tmsocyfc	381	8	of	of	IN
cord-290566-tmsocyfc	381	9	targeted	target	VBN
cord-290566-tmsocyfc	381	10	disruption	disruption	NN
cord-290566-tmsocyfc	381	11	of	of	IN
cord-290566-tmsocyfc	381	12	STAT4	stat4	NN
cord-290566-tmsocyfc	382	1	and	and	CC
cord-290566-tmsocyfc	382	2	STAT6	STAT6	NNS
cord-290566-tmsocyfc	382	3	on	on	IN
cord-290566-tmsocyfc	382	4	the	the	DT
cord-290566-tmsocyfc	382	5	induction	induction	NN
cord-290566-tmsocyfc	382	6	of	of	IN
cord-290566-tmsocyfc	382	7	experimental	experimental	JJ
cord-290566-tmsocyfc	382	8	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	382	9	encephalomyelitis	encephalomyelitis	NN
cord-290566-tmsocyfc	382	10	Frequency	Frequency	NNP
cord-290566-tmsocyfc	382	11	of	of	IN
cord-290566-tmsocyfc	382	12	T	T	NNP
cord-290566-tmsocyfc	382	13	cells	cell	NNS
cord-290566-tmsocyfc	382	14	specific	specific	JJ
cord-290566-tmsocyfc	382	15	for	for	IN
cord-290566-tmsocyfc	382	16	myelin	myelin	JJ
cord-290566-tmsocyfc	382	17	basic	basic	JJ
cord-290566-tmsocyfc	382	18	protein	protein	NN
cord-290566-tmsocyfc	382	19	and	and	CC
cord-290566-tmsocyfc	382	20	myelin	myelin	NNP
cord-290566-tmsocyfc	382	21	proteolipid	proteolipid	NN
cord-290566-tmsocyfc	382	22	protein	protein	NN
cord-290566-tmsocyfc	382	23	in	in	IN
cord-290566-tmsocyfc	382	24	blood	blood	NN
cord-290566-tmsocyfc	382	25	and	and	CC
cord-290566-tmsocyfc	382	26	cerebrospinal	cerebrospinal	NN
cord-290566-tmsocyfc	382	27	fluid	fluid	NN
cord-290566-tmsocyfc	382	28	in	in	IN
cord-290566-tmsocyfc	382	29	multiple	multiple	JJ
cord-290566-tmsocyfc	382	30	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	382	31	Characterization	characterization	NN
cord-290566-tmsocyfc	382	32	of	of	IN
cord-290566-tmsocyfc	382	33	Theiler	Theiler	NNP
cord-290566-tmsocyfc	382	34	's	's	POS
cord-290566-tmsocyfc	382	35	murine	murine	JJ
cord-290566-tmsocyfc	382	36	encephalomyelitis	encephalomyelitis	NN
cord-290566-tmsocyfc	382	37	virus	virus	NN
cord-290566-tmsocyfc	382	38	(	(	-LRB-
cord-290566-tmsocyfc	382	39	TMEV)-specific	TMEV)-specific	NNP
cord-290566-tmsocyfc	382	40	delayed	delay	VBN
cord-290566-tmsocyfc	382	41	-	-	HYPH
cord-290566-tmsocyfc	382	42	type	type	NN
cord-290566-tmsocyfc	382	43	hypersensitivity	hypersensitivity	NN
cord-290566-tmsocyfc	382	44	responses	response	NNS
cord-290566-tmsocyfc	382	45	in	in	IN
cord-290566-tmsocyfc	382	46	TMEVinduced	tmevinduced	JJ
cord-290566-tmsocyfc	382	47	demyelinating	demyelinating	NN
cord-290566-tmsocyfc	382	48	disease	disease	NN
cord-290566-tmsocyfc	382	49	:	:	:
cord-290566-tmsocyfc	382	50	Correlation	correlation	NN
cord-290566-tmsocyfc	382	51	with	with	IN
cord-290566-tmsocyfc	382	52	clinical	clinical	JJ
cord-290566-tmsocyfc	382	53	signs	sign	NNS
cord-290566-tmsocyfc	382	54	Elevated	elevate	VBD
cord-290566-tmsocyfc	382	55	interleukin-12	interleukin-12	XX
cord-290566-tmsocyfc	382	56	in	in	IN
cord-290566-tmsocyfc	382	57	progressive	progressive	JJ
cord-290566-tmsocyfc	382	58	multiple	multiple	JJ
cord-290566-tmsocyfc	382	59	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	382	60	correlates	correlate	NNS
cord-290566-tmsocyfc	382	61	with	with	IN
cord-290566-tmsocyfc	382	62	disease	disease	NN
cord-290566-tmsocyfc	382	63	activity	activity	NN
cord-290566-tmsocyfc	382	64	and	and	CC
cord-290566-tmsocyfc	382	65	is	be	VBZ
cord-290566-tmsocyfc	382	66	normalized	normalize	VBN
cord-290566-tmsocyfc	382	67	by	by	IN
cord-290566-tmsocyfc	382	68	pulse	pulse	NN
cord-290566-tmsocyfc	382	69	cyclophosphamide	cyclophosphamide	NN
cord-290566-tmsocyfc	382	70	therapy	therapy	NN
cord-290566-tmsocyfc	382	71	Alterations	alteration	NNS
cord-290566-tmsocyfc	382	72	in	in	IN
cord-290566-tmsocyfc	382	73	levels	level	NNS
cord-290566-tmsocyfc	382	74	of	of	IN
cord-290566-tmsocyfc	382	75	CD28À	cd28à	NN
cord-290566-tmsocyfc	382	76	/	/	SYM
cord-290566-tmsocyfc	382	77	CD8þ	CD8þ	NNP
cord-290566-tmsocyfc	382	78	suppressor	suppressor	NN
cord-290566-tmsocyfc	382	79	cell	cell	NN
cord-290566-tmsocyfc	382	80	precursor	precursor	NN
cord-290566-tmsocyfc	382	81	and	and	CC
cord-290566-tmsocyfc	382	82	CD45ROþ	CD45ROþ	NNP
cord-290566-tmsocyfc	382	83	/	/	SYM
cord-290566-tmsocyfc	382	84	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	382	85	memory	memory	NN
cord-290566-tmsocyfc	382	86	T	t	NN
cord-290566-tmsocyfc	382	87	lymphocytes	lymphocyte	NNS
cord-290566-tmsocyfc	382	88	in	in	IN
cord-290566-tmsocyfc	382	89	the	the	DT
cord-290566-tmsocyfc	382	90	peripheral	peripheral	JJ
cord-290566-tmsocyfc	382	91	blood	blood	NN
cord-290566-tmsocyfc	382	92	of	of	IN
cord-290566-tmsocyfc	382	93	multiple	multiple	JJ
cord-290566-tmsocyfc	382	94	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	382	95	patients	patient	NNS
cord-290566-tmsocyfc	382	96	Autoreactivity	Autoreactivity	NNP
cord-290566-tmsocyfc	382	97	to	to	IN
cord-290566-tmsocyfc	382	98	myelin	myelin	NN
cord-290566-tmsocyfc	382	99	antigens	antigen	NNS
cord-290566-tmsocyfc	382	100	:	:	:
cord-290566-tmsocyfc	382	101	Myelin	Myelin	NNP
cord-290566-tmsocyfc	382	102	/	/	SYM
cord-290566-tmsocyfc	382	103	oligodendrocyte	oligodendrocyte	NNP
cord-290566-tmsocyfc	382	104	glycoprotein	glycoprotein	NN
cord-290566-tmsocyfc	382	105	is	be	VBZ
cord-290566-tmsocyfc	382	106	a	a	DT
cord-290566-tmsocyfc	382	107	prevalent	prevalent	JJ
cord-290566-tmsocyfc	382	108	autoantigen	autoantigen	NN
cord-290566-tmsocyfc	382	109	Ex	Ex	NNP
cord-290566-tmsocyfc	382	110	vivo	vivo	NN
cord-290566-tmsocyfc	382	111	isolation	isolation	NN
cord-290566-tmsocyfc	382	112	and	and	CC
cord-290566-tmsocyfc	382	113	characterization	characterization	NN
cord-290566-tmsocyfc	382	114	of	of	IN
cord-290566-tmsocyfc	382	115	CD4(þ)CD25(þ	CD4(þ)CD25(þ	NNP
cord-290566-tmsocyfc	382	116	)	)	-RRB-
cord-290566-tmsocyfc	383	1	T	t	NN
cord-290566-tmsocyfc	383	2	cells	cell	NNS
cord-290566-tmsocyfc	383	3	with	with	IN
cord-290566-tmsocyfc	383	4	regulatory	regulatory	JJ
cord-290566-tmsocyfc	383	5	properties	property	NNS
cord-290566-tmsocyfc	383	6	from	from	IN
cord-290566-tmsocyfc	383	7	human	human	JJ
cord-290566-tmsocyfc	383	8	blood	blood	NN
cord-290566-tmsocyfc	384	1	Glatiramer	glatiramer	JJ
cord-290566-tmsocyfc	384	2	acetate	acetate	NN
cord-290566-tmsocyfc	384	3	(	(	-LRB-
cord-290566-tmsocyfc	384	4	Copaxone	Copaxone	NNP
cord-290566-tmsocyfc	384	5	)	)	-RRB-
cord-290566-tmsocyfc	384	6	induces	induce	VBZ
cord-290566-tmsocyfc	384	7	degenerate	degenerate	JJ
cord-290566-tmsocyfc	384	8	,	,	,
cord-290566-tmsocyfc	384	9	Th2-polarized	th2-polarized	JJ
cord-290566-tmsocyfc	384	10	immune	immune	JJ
cord-290566-tmsocyfc	384	11	responses	response	NNS
cord-290566-tmsocyfc	384	12	in	in	IN
cord-290566-tmsocyfc	384	13	patients	patient	NNS
cord-290566-tmsocyfc	384	14	with	with	IN
cord-290566-tmsocyfc	384	15	multiple	multiple	JJ
cord-290566-tmsocyfc	384	16	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	384	17	T	t	NN
cord-290566-tmsocyfc	384	18	cell	cell	NN
cord-290566-tmsocyfc	384	19	memory	memory	NN
cord-290566-tmsocyfc	385	1	No	no	DT
cord-290566-tmsocyfc	385	2	evidence	evidence	NN
cord-290566-tmsocyfc	385	3	to	to	TO
cord-290566-tmsocyfc	385	4	support	support	VB
cord-290566-tmsocyfc	385	5	CTLA-4	CTLA-4	NNS
cord-290566-tmsocyfc	385	6	as	as	IN
cord-290566-tmsocyfc	385	7	a	a	DT
cord-290566-tmsocyfc	385	8	susceptibility	susceptibility	NN
cord-290566-tmsocyfc	385	9	gene	gene	NN
cord-290566-tmsocyfc	385	10	in	in	IN
cord-290566-tmsocyfc	385	11	MS	MS	NNP
cord-290566-tmsocyfc	385	12	families	family	NNS
cord-290566-tmsocyfc	385	13	:	:	:
cord-290566-tmsocyfc	385	14	The	the	DT
cord-290566-tmsocyfc	385	15	Canadian	Canadian	NNP
cord-290566-tmsocyfc	385	16	Collaborative	Collaborative	NNP
cord-290566-tmsocyfc	385	17	Study	Study	NNP
cord-290566-tmsocyfc	385	18	DiVerentiation	diverentiation	NN
cord-290566-tmsocyfc	385	19	of	of	IN
cord-290566-tmsocyfc	385	20	T	T	NNP
cord-290566-tmsocyfc	385	21	cell	cell	NN
cord-290566-tmsocyfc	385	22	lymphokine	lymphokine	NN
cord-290566-tmsocyfc	385	23	gene	gene	NN
cord-290566-tmsocyfc	385	24	expression	expression	NN
cord-290566-tmsocyfc	385	25	:	:	:
cord-290566-tmsocyfc	385	26	The	the	DT
cord-290566-tmsocyfc	385	27	in	in	FW
cord-290566-tmsocyfc	385	28	vitro	vitro	FW
cord-290566-tmsocyfc	385	29	acquisition	acquisition	NN
cord-290566-tmsocyfc	385	30	of	of	IN
cord-290566-tmsocyfc	385	31	T	T	NNP
cord-290566-tmsocyfc	385	32	cell	cell	NN
cord-290566-tmsocyfc	385	33	memory	memory	NN
cord-290566-tmsocyfc	385	34	Chemokine	Chemokine	NNP
cord-290566-tmsocyfc	385	35	receptor	receptor	NN
cord-290566-tmsocyfc	385	36	expression	expression	NN
cord-290566-tmsocyfc	385	37	on	on	IN
cord-290566-tmsocyfc	385	38	T	t	NN
cord-290566-tmsocyfc	385	39	cells	cell	NNS
cord-290566-tmsocyfc	385	40	is	be	VBZ
cord-290566-tmsocyfc	385	41	related	relate	VBN
cord-290566-tmsocyfc	385	42	to	to	IN
cord-290566-tmsocyfc	385	43	new	new	JJ
cord-290566-tmsocyfc	385	44	lesion	lesion	NN
cord-290566-tmsocyfc	385	45	development	development	NN
cord-290566-tmsocyfc	385	46	in	in	IN
cord-290566-tmsocyfc	385	47	multiple	multiple	JJ
cord-290566-tmsocyfc	385	48	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	386	1	The	the	DT
cord-290566-tmsocyfc	386	2	ins	in	NNS
cord-290566-tmsocyfc	386	3	and	and	CC
cord-290566-tmsocyfc	386	4	outs	out	NNS
cord-290566-tmsocyfc	386	5	of	of	IN
cord-290566-tmsocyfc	386	6	T	t	NN
cord-290566-tmsocyfc	386	7	-	-	HYPH
cord-290566-tmsocyfc	386	8	lymphocyte	lymphocyte	NN
cord-290566-tmsocyfc	386	9	traYcking	traycking	NN
cord-290566-tmsocyfc	386	10	to	to	IN
cord-290566-tmsocyfc	386	11	the	the	DT
cord-290566-tmsocyfc	386	12	CNS	CNS	NNP
cord-290566-tmsocyfc	386	13	:	:	:
cord-290566-tmsocyfc	386	14	Anatomical	anatomical	JJ
cord-290566-tmsocyfc	386	15	sites	site	NNS
cord-290566-tmsocyfc	386	16	and	and	CC
cord-290566-tmsocyfc	386	17	molecular	molecular	JJ
cord-290566-tmsocyfc	386	18	mechanisms	mechanism	NNS
cord-290566-tmsocyfc	386	19	B7	B7	NNP
cord-290566-tmsocyfc	386	20	-	-	HYPH
cord-290566-tmsocyfc	386	21	2	2	CD
cord-290566-tmsocyfc	386	22	)	)	-RRB-
cord-290566-tmsocyfc	386	23	and	and	CC
cord-290566-tmsocyfc	386	24	CD40L	cd40l	VB
cord-290566-tmsocyfc	386	25	expression	expression	NN
cord-290566-tmsocyfc	386	26	in	in	IN
cord-290566-tmsocyfc	386	27	relapsing	relapse	VBG
cord-290566-tmsocyfc	386	28	and	and	CC
cord-290566-tmsocyfc	386	29	progressive	progressive	JJ
cord-290566-tmsocyfc	386	30	multiple	multiple	JJ
cord-290566-tmsocyfc	386	31	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	386	32	Induction	induction	NN
cord-290566-tmsocyfc	386	33	of	of	IN
cord-290566-tmsocyfc	386	34	circulating	circulate	VBG
cord-290566-tmsocyfc	386	35	myelin	myelin	JJ
cord-290566-tmsocyfc	386	36	basic	basic	JJ
cord-290566-tmsocyfc	386	37	protein	protein	NN
cord-290566-tmsocyfc	386	38	and	and	CC
cord-290566-tmsocyfc	386	39	proteolipid	proteolipid	NN
cord-290566-tmsocyfc	386	40	protein	protein	NN
cord-290566-tmsocyfc	386	41	-	-	HYPH
cord-290566-tmsocyfc	386	42	specific	specific	JJ
cord-290566-tmsocyfc	386	43	transforming	transform	VBG
cord-290566-tmsocyfc	386	44	growth	growth	NN
cord-290566-tmsocyfc	386	45	factor	factor	NN
cord-290566-tmsocyfc	386	46	-	-	HYPH
cord-290566-tmsocyfc	386	47	beta1-secreting	beta1-secrete	VBG
cord-290566-tmsocyfc	386	48	Th3	th3	NN
cord-290566-tmsocyfc	386	49	T	t	NN
cord-290566-tmsocyfc	386	50	cells	cell	NNS
cord-290566-tmsocyfc	386	51	by	by	IN
cord-290566-tmsocyfc	386	52	oral	oral	JJ
cord-290566-tmsocyfc	386	53	administration	administration	NN
cord-290566-tmsocyfc	386	54	of	of	IN
cord-290566-tmsocyfc	386	55	myelin	myelin	NNP
cord-290566-tmsocyfc	386	56	in	in	IN
cord-290566-tmsocyfc	386	57	multiple	multiple	JJ
cord-290566-tmsocyfc	386	58	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	386	59	patients	patient	NNS
cord-290566-tmsocyfc	386	60	CTLA-4	CTLA-4	NNP
cord-290566-tmsocyfc	386	61	gene	gene	NN
cord-290566-tmsocyfc	386	62	polymorphism	polymorphism	NN
cord-290566-tmsocyfc	386	63	may	may	MD
cord-290566-tmsocyfc	386	64	modulate	modulate	VB
cord-290566-tmsocyfc	386	65	disease	disease	NN
cord-290566-tmsocyfc	386	66	in	in	IN
cord-290566-tmsocyfc	386	67	Japanese	japanese	JJ
cord-290566-tmsocyfc	386	68	multiple	multiple	JJ
cord-290566-tmsocyfc	386	69	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	386	70	patients	patient	NNS
cord-290566-tmsocyfc	387	1	Glatiramer	glatiramer	JJ
cord-290566-tmsocyfc	387	2	acetate	acetate	NN
cord-290566-tmsocyfc	387	3	(	(	-LRB-
cord-290566-tmsocyfc	387	4	Copaxone	Copaxone	NNP
cord-290566-tmsocyfc	387	5	)	)	-RRB-
cord-290566-tmsocyfc	387	6	treatment	treatment	NN
cord-290566-tmsocyfc	387	7	in	in	IN
cord-290566-tmsocyfc	387	8	relapsing	relapse	VBG
cord-290566-tmsocyfc	387	9	-	-	HYPH
cord-290566-tmsocyfc	387	10	remitting	remit	VBG
cord-290566-tmsocyfc	387	11	MS	ms	NN
cord-290566-tmsocyfc	387	12	:	:	:
cord-290566-tmsocyfc	388	1	Quantitative	quantitative	JJ
cord-290566-tmsocyfc	388	2	MR	MR	NNP
cord-290566-tmsocyfc	388	3	assessment	assessment	NN
cord-290566-tmsocyfc	388	4	Increased	increase	VBN
cord-290566-tmsocyfc	388	5	CD80(þ	CD80(þ	NNP
cord-290566-tmsocyfc	388	6	)	)	-RRB-
cord-290566-tmsocyfc	389	1	B	b	NN
cord-290566-tmsocyfc	389	2	cells	cell	NNS
cord-290566-tmsocyfc	389	3	in	in	IN
cord-290566-tmsocyfc	389	4	active	active	JJ
cord-290566-tmsocyfc	389	5	multiple	multiple	JJ
cord-290566-tmsocyfc	389	6	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	389	7	and	and	CC
cord-290566-tmsocyfc	389	8	reversal	reversal	NN
cord-290566-tmsocyfc	389	9	by	by	IN
cord-290566-tmsocyfc	389	10	interferon	interferon	NN
cord-290566-tmsocyfc	389	11	beta-1b	beta-1b	VBZ
cord-290566-tmsocyfc	389	12	therapy	therapy	NN
cord-290566-tmsocyfc	389	13	CD40-CD40	cd40-cd40	NN
cord-290566-tmsocyfc	389	14	ligand	ligand	NN
cord-290566-tmsocyfc	389	15	interactions	interaction	NNS
cord-290566-tmsocyfc	389	16	in	in	IN
cord-290566-tmsocyfc	389	17	experimental	experimental	JJ
cord-290566-tmsocyfc	389	18	allergic	allergic	JJ
cord-290566-tmsocyfc	389	19	encephalomyelitis	encephalomyelitis	NN
cord-290566-tmsocyfc	389	20	and	and	CC
cord-290566-tmsocyfc	389	21	multiple	multiple	JJ
cord-290566-tmsocyfc	389	22	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	389	23	Vulnerability	vulnerability	NN
cord-290566-tmsocyfc	389	24	of	of	IN
cord-290566-tmsocyfc	389	25	human	human	JJ
cord-290566-tmsocyfc	389	26	neurons	neuron	NNS
cord-290566-tmsocyfc	389	27	to	to	IN
cord-290566-tmsocyfc	389	28	T	T	NNP
cord-290566-tmsocyfc	389	29	cell	cell	NN
cord-290566-tmsocyfc	389	30	-	-	HYPH
cord-290566-tmsocyfc	389	31	mediated	mediate	VBN
cord-290566-tmsocyfc	389	32	cytotoxicity	cytotoxicity	NN
cord-290566-tmsocyfc	389	33	Detection	detection	NN
cord-290566-tmsocyfc	389	34	of	of	IN
cord-290566-tmsocyfc	389	35	skewed	skewed	JJ
cord-290566-tmsocyfc	389	36	T	t	NN
cord-290566-tmsocyfc	389	37	-	-	HYPH
cord-290566-tmsocyfc	389	38	cell	cell	NN
cord-290566-tmsocyfc	389	39	receptor	receptor	NN
cord-290566-tmsocyfc	389	40	V	v	NN
cord-290566-tmsocyfc	389	41	-	-	HYPH
cord-290566-tmsocyfc	389	42	beta	beta	NN
cord-290566-tmsocyfc	389	43	gene	gene	NN
cord-290566-tmsocyfc	389	44	usage	usage	NN
cord-290566-tmsocyfc	389	45	in	in	IN
cord-290566-tmsocyfc	389	46	the	the	DT
cord-290566-tmsocyfc	389	47	peripheral	peripheral	JJ
cord-290566-tmsocyfc	389	48	blood	blood	NN
cord-290566-tmsocyfc	389	49	of	of	IN
cord-290566-tmsocyfc	389	50	patients	patient	NNS
cord-290566-tmsocyfc	389	51	with	with	IN
cord-290566-tmsocyfc	389	52	multiple	multiple	JJ
cord-290566-tmsocyfc	389	53	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	390	1	Myelin	myelin	JJ
cord-290566-tmsocyfc	390	2	basic	basic	JJ
cord-290566-tmsocyfc	390	3	protein	protein	NN
cord-290566-tmsocyfc	390	4	and	and	CC
cord-290566-tmsocyfc	390	5	proteolipid	proteolipid	NN
cord-290566-tmsocyfc	390	6	protein	protein	NN
cord-290566-tmsocyfc	390	7	reactivity	reactivity	NN
cord-290566-tmsocyfc	390	8	of	of	IN
cord-290566-tmsocyfc	390	9	brain	brain	NN
cord-290566-tmsocyfc	390	10	-	-	HYPH
cord-290566-tmsocyfc	390	11	and	and	CC
cord-290566-tmsocyfc	390	12	cerebrospinal	cerebrospinal	JJ
cord-290566-tmsocyfc	390	13	fluid	fluid	NN
cord-290566-tmsocyfc	390	14	-	-	HYPH
cord-290566-tmsocyfc	390	15	derived	derive	VBN
cord-290566-tmsocyfc	390	16	T	t	NN
cord-290566-tmsocyfc	390	17	cell	cell	NN
cord-290566-tmsocyfc	390	18	clones	clone	NNS
cord-290566-tmsocyfc	390	19	in	in	IN
cord-290566-tmsocyfc	390	20	multiple	multiple	JJ
cord-290566-tmsocyfc	390	21	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	390	22	and	and	CC
cord-290566-tmsocyfc	390	23	postinfectious	postinfectious	NNP
cord-290566-tmsocyfc	390	24	encephalomyelitis	encephalomyelitis	NN
cord-290566-tmsocyfc	390	25	Oral	Oral	NNP
cord-290566-tmsocyfc	390	26	administration	administration	NN
cord-290566-tmsocyfc	390	27	of	of	IN
cord-290566-tmsocyfc	390	28	myelin	myelin	NNP
cord-290566-tmsocyfc	390	29	induces	induce	VBZ
cord-290566-tmsocyfc	390	30	antigen	antigen	NN
cord-290566-tmsocyfc	390	31	-	-	HYPH
cord-290566-tmsocyfc	390	32	specific	specific	JJ
cord-290566-tmsocyfc	390	33	TGF	TGF	NNP
cord-290566-tmsocyfc	390	34	-	-	HYPH
cord-290566-tmsocyfc	390	35	beta	beta	NN
cord-290566-tmsocyfc	390	36	1	1	CD
cord-290566-tmsocyfc	390	37	secreting	secrete	VBG
cord-290566-tmsocyfc	390	38	T	t	NN
cord-290566-tmsocyfc	390	39	cells	cell	NNS
cord-290566-tmsocyfc	390	40	in	in	IN
cord-290566-tmsocyfc	390	41	patients	patient	NNS
cord-290566-tmsocyfc	390	42	with	with	IN
cord-290566-tmsocyfc	390	43	multiple	multiple	JJ
cord-290566-tmsocyfc	390	44	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	391	1	Interleukin	interleukin	NN
cord-290566-tmsocyfc	391	2	17-producing	17-producing	CD
cord-290566-tmsocyfc	391	3	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	391	4	eVector	eVector	NNP
cord-290566-tmsocyfc	391	5	T	T	NNP
cord-290566-tmsocyfc	391	6	cells	cell	NNS
cord-290566-tmsocyfc	391	7	develop	develop	VBP
cord-290566-tmsocyfc	391	8	via	via	IN
cord-290566-tmsocyfc	391	9	a	a	DT
cord-290566-tmsocyfc	391	10	lineage	lineage	NN
cord-290566-tmsocyfc	391	11	distinct	distinct	JJ
cord-290566-tmsocyfc	391	12	from	from	IN
cord-290566-tmsocyfc	391	13	the	the	DT
cord-290566-tmsocyfc	391	14	T	T	NNP
cord-290566-tmsocyfc	391	15	helper	helper	NN
cord-290566-tmsocyfc	391	16	type	type	NN
cord-290566-tmsocyfc	391	17	1	1	CD
cord-290566-tmsocyfc	391	18	and	and	CC
cord-290566-tmsocyfc	391	19	2	2	CD
cord-290566-tmsocyfc	391	20	lineages	lineage	NNS
cord-290566-tmsocyfc	391	21	Immunologic	immunologic	JJ
cord-290566-tmsocyfc	391	22	studies	study	NNS
cord-290566-tmsocyfc	391	23	of	of	IN
cord-290566-tmsocyfc	391	24	patients	patient	NNS
cord-290566-tmsocyfc	391	25	with	with	IN
cord-290566-tmsocyfc	391	26	chronic	chronic	JJ
cord-290566-tmsocyfc	391	27	encephalitis	encephalitis	NN
cord-290566-tmsocyfc	391	28	induced	induce	VBN
cord-290566-tmsocyfc	391	29	by	by	IN
cord-290566-tmsocyfc	391	30	post	post	JJ
cord-290566-tmsocyfc	391	31	-	-	JJ
cord-290566-tmsocyfc	391	32	exposure	exposure	JJ
cord-290566-tmsocyfc	391	33	Semple	Semple	NNP
cord-290566-tmsocyfc	391	34	rabies	rabie	NNS
cord-290566-tmsocyfc	391	35	vaccine	vaccine	NN
cord-290566-tmsocyfc	392	1	The	the	DT
cord-290566-tmsocyfc	392	2	proto	proto	JJ
cord-290566-tmsocyfc	392	3	-	-	HYPH
cord-290566-tmsocyfc	392	4	oncogene	oncogene	NN
cord-290566-tmsocyfc	392	5	c	c	NN
cord-290566-tmsocyfc	392	6	-	-	HYPH
cord-290566-tmsocyfc	392	7	maf	maf	NNP
cord-290566-tmsocyfc	392	8	is	be	VBZ
cord-290566-tmsocyfc	392	9	responsible	responsible	JJ
cord-290566-tmsocyfc	392	10	for	for	IN
cord-290566-tmsocyfc	392	11	tissue	tissue	NN
cord-290566-tmsocyfc	392	12	-	-	HYPH
cord-290566-tmsocyfc	392	13	specific	specific	JJ
cord-290566-tmsocyfc	392	14	expression	expression	NN
cord-290566-tmsocyfc	392	15	of	of	IN
cord-290566-tmsocyfc	392	16	interleukin-4	interleukin-4	NNP
cord-290566-tmsocyfc	392	17	Immunoregulatory	Immunoregulatory	NNP
cord-290566-tmsocyfc	392	18	molecules	molecule	NNS
cord-290566-tmsocyfc	392	19	and	and	CC
cord-290566-tmsocyfc	392	20	IL	IL	NNP
cord-290566-tmsocyfc	392	21	2	2	CD
cord-290566-tmsocyfc	392	22	receptors	receptor	NNS
cord-290566-tmsocyfc	392	23	identified	identify	VBN
cord-290566-tmsocyfc	392	24	in	in	IN
cord-290566-tmsocyfc	392	25	multiple	multiple	JJ
cord-290566-tmsocyfc	392	26	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	392	27	brain	brain	NN
cord-290566-tmsocyfc	392	28	Tumor	Tumor	NNP
cord-290566-tmsocyfc	392	29	necrosis	necrosis	NN
cord-290566-tmsocyfc	392	30	factor	factor	NN
cord-290566-tmsocyfc	392	31	identified	identify	VBN
cord-290566-tmsocyfc	392	32	in	in	IN
cord-290566-tmsocyfc	392	33	multiple	multiple	JJ
cord-290566-tmsocyfc	392	34	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	392	35	brain	brain	NN
cord-290566-tmsocyfc	392	36	Myelin	Myelin	NNP
cord-290566-tmsocyfc	392	37	-	-	HYPH
cord-290566-tmsocyfc	392	38	associated	associate	VBN
cord-290566-tmsocyfc	392	39	oligodendrocytic	oligodendrocytic	JJ
cord-290566-tmsocyfc	392	40	basic	basic	JJ
cord-290566-tmsocyfc	392	41	protein	protein	NN
cord-290566-tmsocyfc	392	42	:	:	:
cord-290566-tmsocyfc	392	43	Identification	identification	NN
cord-290566-tmsocyfc	392	44	of	of	IN
cord-290566-tmsocyfc	392	45	an	an	DT
cord-290566-tmsocyfc	392	46	encephalitogenic	encephalitogenic	NNP
cord-290566-tmsocyfc	392	47	epitope	epitope	NN
cord-290566-tmsocyfc	392	48	and	and	CC
cord-290566-tmsocyfc	392	49	association	association	NN
cord-290566-tmsocyfc	392	50	with	with	IN
cord-290566-tmsocyfc	392	51	multiple	multiple	JJ
cord-290566-tmsocyfc	392	52	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	392	53	Control	Control	NNP
cord-290566-tmsocyfc	392	54	of	of	IN
cord-290566-tmsocyfc	392	55	regulatory	regulatory	JJ
cord-290566-tmsocyfc	392	56	T	t	NN
cord-290566-tmsocyfc	392	57	cell	cell	NN
cord-290566-tmsocyfc	392	58	development	development	NN
cord-290566-tmsocyfc	392	59	by	by	IN
cord-290566-tmsocyfc	392	60	the	the	DT
cord-290566-tmsocyfc	392	61	transcription	transcription	NN
cord-290566-tmsocyfc	392	62	factor	factor	NN
cord-290566-tmsocyfc	392	63	Foxp3	Foxp3	VBN
cord-290566-tmsocyfc	392	64	Intrathecal	Intrathecal	NNP
cord-290566-tmsocyfc	392	65	activation	activation	NN
cord-290566-tmsocyfc	392	66	of	of	IN
cord-290566-tmsocyfc	392	67	the	the	DT
cord-290566-tmsocyfc	392	68	IL-17	IL-17	NNP
cord-290566-tmsocyfc	392	69	/	/	SYM
cord-290566-tmsocyfc	392	70	IL-8	IL-8	NNP
cord-290566-tmsocyfc	392	71	axis	axis	NN
cord-290566-tmsocyfc	392	72	in	in	IN
cord-290566-tmsocyfc	392	73	opticospinal	opticospinal	JJ
cord-290566-tmsocyfc	392	74	multiple	multiple	JJ
cord-290566-tmsocyfc	392	75	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	393	1	Interleukin	interleukin	NN
cord-290566-tmsocyfc	393	2	12	12	CD
cord-290566-tmsocyfc	393	3	signaling	signal	VBG
cord-290566-tmsocyfc	393	4	in	in	IN
cord-290566-tmsocyfc	393	5	T	T	NNP
cord-290566-tmsocyfc	393	6	helper	helper	NN
cord-290566-tmsocyfc	393	7	type	type	NN
cord-290566-tmsocyfc	393	8	1	1	CD
cord-290566-tmsocyfc	393	9	(	(	-LRB-
cord-290566-tmsocyfc	393	10	Th1	Th1	NNP
cord-290566-tmsocyfc	393	11	)	)	-RRB-
cord-290566-tmsocyfc	393	12	cells	cell	NNS
cord-290566-tmsocyfc	393	13	involves	involve	VBZ
cord-290566-tmsocyfc	393	14	tyrosine	tyrosine	NN
cord-290566-tmsocyfc	393	15	phosphorylation	phosphorylation	NN
cord-290566-tmsocyfc	393	16	of	of	IN
cord-290566-tmsocyfc	393	17	signal	signal	NN
cord-290566-tmsocyfc	393	18	transducer	transducer	NN
cord-290566-tmsocyfc	393	19	and	and	CC
cord-290566-tmsocyfc	393	20	activator	activator	NN
cord-290566-tmsocyfc	393	21	of	of	IN
cord-290566-tmsocyfc	393	22	transcription	transcription	NN
cord-290566-tmsocyfc	393	23	(	(	-LRB-
cord-290566-tmsocyfc	393	24	Stat)3	Stat)3	NNP
cord-290566-tmsocyfc	393	25	and	and	CC
cord-290566-tmsocyfc	393	26	Stat4	Stat4	NNP
cord-290566-tmsocyfc	393	27	Increased	increase	VBD
cord-290566-tmsocyfc	393	28	T	T	NNP
cord-290566-tmsocyfc	393	29	cell	cell	NN
cord-290566-tmsocyfc	393	30	expression	expression	NN
cord-290566-tmsocyfc	393	31	of	of	IN
cord-290566-tmsocyfc	393	32	CD154	CD154	NNP
cord-290566-tmsocyfc	393	33	(	(	-LRB-
cord-290566-tmsocyfc	393	34	CD40-ligand	CD40-ligand	NNP
cord-290566-tmsocyfc	393	35	)	)	-RRB-
cord-290566-tmsocyfc	393	36	in	in	IN
cord-290566-tmsocyfc	393	37	multiple	multiple	JJ
cord-290566-tmsocyfc	393	38	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	394	1	Copolymer	copolymer	NN
cord-290566-tmsocyfc	394	2	1	1	CD
cord-290566-tmsocyfc	394	3	reduces	reduce	VBZ
cord-290566-tmsocyfc	394	4	relapse	relapse	NN
cord-290566-tmsocyfc	394	5	rate	rate	NN
cord-290566-tmsocyfc	394	6	and	and	CC
cord-290566-tmsocyfc	394	7	improves	improve	VBZ
cord-290566-tmsocyfc	394	8	disability	disability	NN
cord-290566-tmsocyfc	394	9	in	in	IN
cord-290566-tmsocyfc	394	10	relapsing	relapse	VBG
cord-290566-tmsocyfc	394	11	-	-	HYPH
cord-290566-tmsocyfc	394	12	remitting	remit	VBG
cord-290566-tmsocyfc	394	13	multiple	multiple	JJ
cord-290566-tmsocyfc	394	14	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	394	15	:	:	:
cord-290566-tmsocyfc	395	1	Results	result	NNS
cord-290566-tmsocyfc	395	2	of	of	IN
cord-290566-tmsocyfc	395	3	a	a	DT
cord-290566-tmsocyfc	395	4	phase	phase	NN
cord-290566-tmsocyfc	395	5	III	iii	CD
cord-290566-tmsocyfc	395	6	multicenter	multicenter	JJ
cord-290566-tmsocyfc	395	7	,	,	,
cord-290566-tmsocyfc	395	8	double	double	JJ
cord-290566-tmsocyfc	395	9	-	-	HYPH
cord-290566-tmsocyfc	395	10	blind	blind	JJ
cord-290566-tmsocyfc	395	11	placebo	placebo	NN
cord-290566-tmsocyfc	395	12	-	-	HYPH
cord-290566-tmsocyfc	395	13	controlled	control	VBN
cord-290566-tmsocyfc	395	14	trial	trial	NN
cord-290566-tmsocyfc	395	15	.	.	.
cord-290566-tmsocyfc	396	1	The	the	DT
cord-290566-tmsocyfc	396	2	Copolymer	Copolymer	NNP
cord-290566-tmsocyfc	396	3	1	1	CD
cord-290566-tmsocyfc	396	4	Multiple	Multiple	NNP
cord-290566-tmsocyfc	396	5	Sclerosis	Sclerosis	NNP
cord-290566-tmsocyfc	396	6	Study	Study	NNP
cord-290566-tmsocyfc	396	7	Group	Group	NNP
cord-290566-tmsocyfc	396	8	Copolymer	Copolymer	NNP
cord-290566-tmsocyfc	396	9	1	1	CD
cord-290566-tmsocyfc	396	10	THE	the	DT
cord-290566-tmsocyfc	396	11	ROLE	role	NN
cord-290566-tmsocyfc	396	12	OF	of	IN
cord-290566-tmsocyfc	396	13	CD4	CD4	NNP
cord-290566-tmsocyfc	396	14	T	T	NNP
cord-290566-tmsocyfc	396	15	CELLS	cell	VBN
cord-290566-tmsocyfc	396	16	IN	in	IN
cord-290566-tmsocyfc	396	17	THE	the	DT
cord-290566-tmsocyfc	396	18	PATHOGENESIS	PATHOGENESIS	NNP
cord-290566-tmsocyfc	396	19	65	65	CD
cord-290566-tmsocyfc	396	20	reduces	reduce	VBZ
cord-290566-tmsocyfc	396	21	relapse	relapse	NN
cord-290566-tmsocyfc	396	22	rate	rate	NN
cord-290566-tmsocyfc	396	23	and	and	CC
cord-290566-tmsocyfc	396	24	improves	improve	VBZ
cord-290566-tmsocyfc	396	25	disability	disability	NN
cord-290566-tmsocyfc	396	26	in	in	IN
cord-290566-tmsocyfc	396	27	relapsing	relapse	VBG
cord-290566-tmsocyfc	396	28	-	-	HYPH
cord-290566-tmsocyfc	396	29	remitting	remit	VBG
cord-290566-tmsocyfc	396	30	multiple	multiple	JJ
cord-290566-tmsocyfc	396	31	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	396	32	:	:	:
cord-290566-tmsocyfc	397	1	Results	result	NNS
cord-290566-tmsocyfc	397	2	of	of	IN
cord-290566-tmsocyfc	397	3	a	a	DT
cord-290566-tmsocyfc	397	4	phase	phase	NN
cord-290566-tmsocyfc	397	5	III	iii	CD
cord-290566-tmsocyfc	397	6	multicenter	multicenter	JJ
cord-290566-tmsocyfc	397	7	,	,	,
cord-290566-tmsocyfc	397	8	double	double	JJ
cord-290566-tmsocyfc	397	9	-	-	HYPH
cord-290566-tmsocyfc	397	10	blind	blind	JJ
cord-290566-tmsocyfc	397	11	,	,	,
cord-290566-tmsocyfc	397	12	placebo	placebo	NN
cord-290566-tmsocyfc	397	13	-	-	HYPH
cord-290566-tmsocyfc	397	14	controlled	control	VBN
cord-290566-tmsocyfc	397	15	trial	trial	NN
cord-290566-tmsocyfc	397	16	Pathological	pathological	JJ
cord-290566-tmsocyfc	397	17	CNS	CNS	NNP
cord-290566-tmsocyfc	397	18	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	397	19	disease	disease	NN
cord-290566-tmsocyfc	397	20	triggered	trigger	VBN
cord-290566-tmsocyfc	397	21	by	by	IN
cord-290566-tmsocyfc	397	22	traumatic	traumatic	JJ
cord-290566-tmsocyfc	397	23	spinal	spinal	JJ
cord-290566-tmsocyfc	397	24	cord	cord	NN
cord-290566-tmsocyfc	397	25	injury	injury	NN
cord-290566-tmsocyfc	397	26	:	:	:
cord-290566-tmsocyfc	397	27	Implications	implication	NNS
cord-290566-tmsocyfc	397	28	for	for	IN
cord-290566-tmsocyfc	397	29	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	397	30	vaccine	vaccine	NN
cord-290566-tmsocyfc	397	31	therapy	therapy	NN
cord-290566-tmsocyfc	397	32	CTLA4	CTLA4	NNP
cord-290566-tmsocyfc	397	33	is	be	VBZ
cord-290566-tmsocyfc	397	34	associated	associate	VBN
cord-290566-tmsocyfc	397	35	with	with	IN
cord-290566-tmsocyfc	397	36	susceptibility	susceptibility	NN
cord-290566-tmsocyfc	397	37	to	to	IN
cord-290566-tmsocyfc	397	38	multiple	multiple	JJ
cord-290566-tmsocyfc	397	39	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	398	1	Impaired	impaired	JJ
cord-290566-tmsocyfc	398	2	IL-12	IL-12	NNP
cord-290566-tmsocyfc	398	3	responses	response	NNS
cord-290566-tmsocyfc	398	4	and	and	CC
cord-290566-tmsocyfc	398	5	enhanced	enhance	VBN
cord-290566-tmsocyfc	398	6	development	development	NN
cord-290566-tmsocyfc	398	7	of	of	IN
cord-290566-tmsocyfc	398	8	Th2	th2	CD
cord-290566-tmsocyfc	398	9	cells	cell	NNS
cord-290566-tmsocyfc	398	10	in	in	IN
cord-290566-tmsocyfc	398	11	Stat4-deficient	Stat4-deficient	NNP
cord-290566-tmsocyfc	398	12	mice	mouse	NNS
cord-290566-tmsocyfc	399	1	Induction	induction	NN
cord-290566-tmsocyfc	399	2	of	of	IN
cord-290566-tmsocyfc	399	3	a	a	DT
cord-290566-tmsocyfc	399	4	non	non	JJ
cord-290566-tmsocyfc	399	5	-	-	JJ
cord-290566-tmsocyfc	399	6	encephalitogenic	encephalitogenic	JJ
cord-290566-tmsocyfc	399	7	type	type	NN
cord-290566-tmsocyfc	399	8	2	2	CD
cord-290566-tmsocyfc	399	9	T	t	NN
cord-290566-tmsocyfc	399	10	helper	helper	NN
cord-290566-tmsocyfc	399	11	-	-	HYPH
cord-290566-tmsocyfc	399	12	cell	cell	NN
cord-290566-tmsocyfc	399	13	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	399	14	response	response	NN
cord-290566-tmsocyfc	399	15	in	in	IN
cord-290566-tmsocyfc	399	16	multiple	multiple	JJ
cord-290566-tmsocyfc	399	17	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	399	18	after	after	IN
cord-290566-tmsocyfc	399	19	administration	administration	NN
cord-290566-tmsocyfc	399	20	of	of	IN
cord-290566-tmsocyfc	399	21	an	an	DT
cord-290566-tmsocyfc	399	22	altered	altered	JJ
cord-290566-tmsocyfc	399	23	peptide	peptide	NN
cord-290566-tmsocyfc	399	24	ligand	ligand	NN
cord-290566-tmsocyfc	399	25	in	in	IN
cord-290566-tmsocyfc	399	26	a	a	DT
cord-290566-tmsocyfc	399	27	placebo	placebo	NN
cord-290566-tmsocyfc	399	28	-	-	HYPH
cord-290566-tmsocyfc	399	29	controlled	control	VBN
cord-290566-tmsocyfc	399	30	,	,	,
cord-290566-tmsocyfc	399	31	randomized	randomized	JJ
cord-290566-tmsocyfc	399	32	phase	phase	NN
cord-290566-tmsocyfc	399	33	II	II	NNP
cord-290566-tmsocyfc	399	34	trial	trial	NN
cord-290566-tmsocyfc	399	35	.	.	.
cord-290566-tmsocyfc	400	1	The	the	DT
cord-290566-tmsocyfc	400	2	Altered	Altered	NNP
cord-290566-tmsocyfc	400	3	Peptide	Peptide	NNP
cord-290566-tmsocyfc	400	4	Ligand	Ligand	NNP
cord-290566-tmsocyfc	400	5	in	in	IN
cord-290566-tmsocyfc	400	6	Relapsing	Relapsing	NNP
cord-290566-tmsocyfc	400	7	MS	MS	NNP
cord-290566-tmsocyfc	400	8	Study	Study	NNP
cord-290566-tmsocyfc	400	9	Group	Group	NNP
cord-290566-tmsocyfc	400	10	Increased	increase	VBN
cord-290566-tmsocyfc	400	11	lymphocyte	lymphocyte	NN
cord-290566-tmsocyfc	400	12	beta	beta	NN
cord-290566-tmsocyfc	400	13	-	-	HYPH
cord-290566-tmsocyfc	400	14	adrenergic	adrenergic	NN
cord-290566-tmsocyfc	400	15	receptor	receptor	NN
cord-290566-tmsocyfc	400	16	density	density	NN
cord-290566-tmsocyfc	400	17	in	in	IN
cord-290566-tmsocyfc	400	18	progressive	progressive	JJ
cord-290566-tmsocyfc	400	19	multiple	multiple	JJ
cord-290566-tmsocyfc	400	20	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	400	21	is	be	VBZ
cord-290566-tmsocyfc	400	22	specific	specific	JJ
cord-290566-tmsocyfc	400	23	for	for	IN
cord-290566-tmsocyfc	400	24	the	the	DT
cord-290566-tmsocyfc	400	25	CD8þ	CD8þ	NNP
cord-290566-tmsocyfc	400	26	,	,	,
cord-290566-tmsocyfc	400	27	CD28À	cd28à	RB
cord-290566-tmsocyfc	400	28	suppressor	suppressor	NN
cord-290566-tmsocyfc	400	29	cell	cell	NN
cord-290566-tmsocyfc	400	30	Reversal	reversal	NN
cord-290566-tmsocyfc	400	31	of	of	IN
cord-290566-tmsocyfc	400	32	experimental	experimental	JJ
cord-290566-tmsocyfc	400	33	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	400	34	encephalomyelitis	encephalomyelitis	NN
cord-290566-tmsocyfc	400	35	by	by	IN
cord-290566-tmsocyfc	400	36	a	a	DT
cord-290566-tmsocyfc	400	37	soluble	soluble	JJ
cord-290566-tmsocyfc	400	38	peptide	peptide	NN
cord-290566-tmsocyfc	400	39	variant	variant	NN
cord-290566-tmsocyfc	400	40	of	of	IN
cord-290566-tmsocyfc	400	41	a	a	DT
cord-290566-tmsocyfc	400	42	myelin	myelin	JJ
cord-290566-tmsocyfc	400	43	basic	basic	JJ
cord-290566-tmsocyfc	400	44	protein	protein	NN
cord-290566-tmsocyfc	400	45	epitope	epitope	NN
cord-290566-tmsocyfc	400	46	:	:	:
cord-290566-tmsocyfc	400	47	T	T	NNP
cord-290566-tmsocyfc	400	48	cell	cell	NN
cord-290566-tmsocyfc	400	49	receptor	receptor	NN
cord-290566-tmsocyfc	400	50	antagonism	antagonism	NN
cord-290566-tmsocyfc	400	51	and	and	CC
cord-290566-tmsocyfc	400	52	reduction	reduction	NN
cord-290566-tmsocyfc	400	53	of	of	IN
cord-290566-tmsocyfc	400	54	interferon	interferon	NN
cord-290566-tmsocyfc	400	55	gamma	gamma	NN
cord-290566-tmsocyfc	400	56	and	and	CC
cord-290566-tmsocyfc	400	57	tumor	tumor	NN
cord-290566-tmsocyfc	400	58	necrosis	necrosis	NN
cord-290566-tmsocyfc	400	59	factor	factor	NN
cord-290566-tmsocyfc	400	60	alpha	alpha	NN
cord-290566-tmsocyfc	400	61	production	production	NN
cord-290566-tmsocyfc	400	62	IL-18	IL-18	NNP
cord-290566-tmsocyfc	400	63	is	be	VBZ
cord-290566-tmsocyfc	400	64	linked	link	VBN
cord-290566-tmsocyfc	400	65	to	to	IN
cord-290566-tmsocyfc	400	66	raised	raise	VBN
cord-290566-tmsocyfc	400	67	IFN	IFN	NNP
cord-290566-tmsocyfc	400	68	-	-	HYPH
cord-290566-tmsocyfc	400	69	gamma	gamma	NN
cord-290566-tmsocyfc	400	70	in	in	IN
cord-290566-tmsocyfc	400	71	multiple	multiple	JJ
cord-290566-tmsocyfc	400	72	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	400	73	and	and	CC
cord-290566-tmsocyfc	400	74	is	be	VBZ
cord-290566-tmsocyfc	400	75	induced	induce	VBN
cord-290566-tmsocyfc	400	76	by	by	IN
cord-290566-tmsocyfc	400	77	activated	activate	VBN
cord-290566-tmsocyfc	400	78	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	400	79	T	T	NNP
cord-290566-tmsocyfc	400	80	cells	cell	NNS
cord-290566-tmsocyfc	400	81	via	via	IN
cord-290566-tmsocyfc	400	82	CD40-CD40	cd40-cd40	NN
cord-290566-tmsocyfc	400	83	ligand	ligand	NN
cord-290566-tmsocyfc	400	84	interactions	interaction	NNS
cord-290566-tmsocyfc	401	1	Interleukin-12	Interleukin-12	NNP
cord-290566-tmsocyfc	401	2	production	production	NN
cord-290566-tmsocyfc	401	3	by	by	IN
cord-290566-tmsocyfc	401	4	dendritic	dendritic	JJ
cord-290566-tmsocyfc	401	5	cells	cell	NNS
cord-290566-tmsocyfc	401	6	.	.	.
cord-290566-tmsocyfc	402	1	The	the	DT
cord-290566-tmsocyfc	402	2	role	role	NN
cord-290566-tmsocyfc	402	3	of	of	IN
cord-290566-tmsocyfc	402	4	CD40-CD40L	cd40-cd40l	CD
cord-290566-tmsocyfc	402	5	interactions	interaction	NNS
cord-290566-tmsocyfc	402	6	in	in	IN
cord-290566-tmsocyfc	402	7	Th1	Th1	NNP
cord-290566-tmsocyfc	402	8	T	t	NN
cord-290566-tmsocyfc	402	9	-	-	HYPH
cord-290566-tmsocyfc	402	10	cell	cell	NN
cord-290566-tmsocyfc	402	11	responses	response	NNS
cord-290566-tmsocyfc	402	12	Reactivity	reactivity	NN
cord-290566-tmsocyfc	402	13	to	to	IN
cord-290566-tmsocyfc	402	14	myelin	myelin	NN
cord-290566-tmsocyfc	402	15	antigens	antigen	NNS
cord-290566-tmsocyfc	402	16	in	in	IN
cord-290566-tmsocyfc	402	17	multiple	multiple	JJ
cord-290566-tmsocyfc	402	18	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	402	19	.	.	.
cord-290566-tmsocyfc	403	1	Peripheral	peripheral	JJ
cord-290566-tmsocyfc	403	2	blood	blood	NN
cord-290566-tmsocyfc	403	3	lymphocytes	lymphocyte	NNS
cord-290566-tmsocyfc	403	4	respond	respond	VBP
cord-290566-tmsocyfc	403	5	predominantly	predominantly	RB
cord-290566-tmsocyfc	403	6	to	to	IN
cord-290566-tmsocyfc	403	7	myelin	myelin	NN
cord-290566-tmsocyfc	403	8	oligodendrocyte	oligodendrocyte	NNP
cord-290566-tmsocyfc	403	9	glycoprotein	glycoprotein	NN
cord-290566-tmsocyfc	403	10	Antibodymediated	Antibodymediated	NNP
cord-290566-tmsocyfc	403	11	suppression	suppression	NN
cord-290566-tmsocyfc	403	12	of	of	IN
cord-290566-tmsocyfc	403	13	V5.2/5.3(þ	V5.2/5.3(þ	NNP
cord-290566-tmsocyfc	403	14	)	)	-RRB-
cord-290566-tmsocyfc	403	15	T	t	NN
cord-290566-tmsocyfc	403	16	cells	cell	NNS
cord-290566-tmsocyfc	403	17	in	in	IN
cord-290566-tmsocyfc	403	18	multiple	multiple	JJ
cord-290566-tmsocyfc	403	19	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	403	20	:	:	:
cord-290566-tmsocyfc	404	1	Results	result	NNS
cord-290566-tmsocyfc	404	2	from	from	IN
cord-290566-tmsocyfc	404	3	an	an	DT
cord-290566-tmsocyfc	404	4	MRImonitored	mrimonitored	JJ
cord-290566-tmsocyfc	404	5	phase	phase	NN
cord-290566-tmsocyfc	404	6	II	ii	CD
cord-290566-tmsocyfc	404	7	clinical	clinical	JJ
cord-290566-tmsocyfc	404	8	trial	trial	NN
cord-290566-tmsocyfc	404	9	Activated	activate	VBN
cord-290566-tmsocyfc	404	10	self	self	NN
cord-290566-tmsocyfc	404	11	-	-	HYPH
cord-290566-tmsocyfc	404	12	MHC	MHC	NNP
cord-290566-tmsocyfc	404	13	-	-	HYPH
cord-290566-tmsocyfc	404	14	reactive	reactive	JJ
cord-290566-tmsocyfc	404	15	T	t	NN
cord-290566-tmsocyfc	404	16	cells	cell	NNS
cord-290566-tmsocyfc	404	17	have	have	VBP
cord-290566-tmsocyfc	404	18	the	the	DT
cord-290566-tmsocyfc	404	19	cytokine	cytokine	JJ
cord-290566-tmsocyfc	404	20	phenotype	phenotype	NN
cord-290566-tmsocyfc	404	21	of	of	IN
cord-290566-tmsocyfc	404	22	Th3	th3	NN
cord-290566-tmsocyfc	404	23	/	/	SYM
cord-290566-tmsocyfc	404	24	T	T	NNP
cord-290566-tmsocyfc	404	25	regulatory	regulatory	JJ
cord-290566-tmsocyfc	404	26	cell	cell	NN
cord-290566-tmsocyfc	404	27	1	1	CD
cord-290566-tmsocyfc	404	28	T	t	NN
cord-290566-tmsocyfc	404	29	cells	cell	NNS
cord-290566-tmsocyfc	404	30	T	t	NN
cord-290566-tmsocyfc	404	31	-	-	HYPH
cord-290566-tmsocyfc	404	32	cells	cell	NNS
cord-290566-tmsocyfc	404	33	in	in	IN
cord-290566-tmsocyfc	404	34	the	the	DT
cord-290566-tmsocyfc	404	35	cerebrospinal	cerebrospinal	JJ
cord-290566-tmsocyfc	404	36	fluid	fluid	NN
cord-290566-tmsocyfc	404	37	express	express	NN
cord-290566-tmsocyfc	404	38	a	a	DT
cord-290566-tmsocyfc	404	39	similar	similar	JJ
cord-290566-tmsocyfc	404	40	repertoire	repertoire	NN
cord-290566-tmsocyfc	404	41	of	of	IN
cord-290566-tmsocyfc	404	42	inflammatory	inflammatory	JJ
cord-290566-tmsocyfc	404	43	chemokine	chemokine	NN
cord-290566-tmsocyfc	404	44	receptors	receptor	NNS
cord-290566-tmsocyfc	404	45	in	in	IN
cord-290566-tmsocyfc	404	46	the	the	DT
cord-290566-tmsocyfc	404	47	absence	absence	NN
cord-290566-tmsocyfc	404	48	or	or	CC
cord-290566-tmsocyfc	404	49	presence	presence	NN
cord-290566-tmsocyfc	404	50	of	of	IN
cord-290566-tmsocyfc	404	51	CNS	CNS	NNP
cord-290566-tmsocyfc	404	52	inflammation	inflammation	NN
cord-290566-tmsocyfc	404	53	:	:	:
cord-290566-tmsocyfc	404	54	Implications	implication	NNS
cord-290566-tmsocyfc	404	55	for	for	IN
cord-290566-tmsocyfc	404	56	CNS	CNS	NNP
cord-290566-tmsocyfc	404	57	traYcking	traYcking	NNP
cord-290566-tmsocyfc	404	58	Expression	expression	NN
cord-290566-tmsocyfc	404	59	of	of	IN
cord-290566-tmsocyfc	404	60	CCR7	CCR7	NNP
cord-290566-tmsocyfc	404	61	in	in	IN
cord-290566-tmsocyfc	404	62	multiple	multiple	JJ
cord-290566-tmsocyfc	404	63	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	404	64	:	:	:
cord-290566-tmsocyfc	404	65	Implications	implication	NNS
cord-290566-tmsocyfc	404	66	for	for	IN
cord-290566-tmsocyfc	404	67	CNS	CNS	NNP
cord-290566-tmsocyfc	404	68	immunity	immunity	NN
cord-290566-tmsocyfc	404	69	Progressive	progressive	JJ
cord-290566-tmsocyfc	404	70	multifocal	multifocal	JJ
cord-290566-tmsocyfc	404	71	leukoencephalopathy	leukoencephalopathy	NNP
cord-290566-tmsocyfc	404	72	complicating	complicate	VBG
cord-290566-tmsocyfc	404	73	treatment	treatment	NN
cord-290566-tmsocyfc	404	74	with	with	IN
cord-290566-tmsocyfc	404	75	natalizumab	natalizumab	NNS
cord-290566-tmsocyfc	404	76	and	and	CC
cord-290566-tmsocyfc	404	77	interferon	interferon	NNP
cord-290566-tmsocyfc	404	78	beta-1a	beta-1a	NNP
cord-290566-tmsocyfc	404	79	for	for	IN
cord-290566-tmsocyfc	404	80	multiple	multiple	JJ
cord-290566-tmsocyfc	404	81	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	405	1	Dysregulated	Dysregulated	NNP
cord-290566-tmsocyfc	405	2	T	T	NNP
cord-290566-tmsocyfc	405	3	cell	cell	NN
cord-290566-tmsocyfc	405	4	expression	expression	NN
cord-290566-tmsocyfc	405	5	of	of	IN
cord-290566-tmsocyfc	405	6	TIM3	TIM3	NNP
cord-290566-tmsocyfc	405	7	in	in	IN
cord-290566-tmsocyfc	405	8	multiple	multiple	JJ
cord-290566-tmsocyfc	405	9	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	405	10	DiVerences	diverence	NNS
cord-290566-tmsocyfc	405	11	in	in	IN
cord-290566-tmsocyfc	405	12	surface	surface	NN
cord-290566-tmsocyfc	405	13	phenotype	phenotype	NN
cord-290566-tmsocyfc	405	14	and	and	CC
cord-290566-tmsocyfc	405	15	mechanism	mechanism	NN
cord-290566-tmsocyfc	405	16	of	of	IN
cord-290566-tmsocyfc	405	17	action	action	NN
cord-290566-tmsocyfc	405	18	between	between	IN
cord-290566-tmsocyfc	405	19	alloantigen	alloantigen	NN
cord-290566-tmsocyfc	405	20	-	-	HYPH
cord-290566-tmsocyfc	405	21	specific	specific	JJ
cord-290566-tmsocyfc	405	22	CD8þ	CD8þ	NNP
cord-290566-tmsocyfc	405	23	cytotoxic	cytotoxic	JJ
cord-290566-tmsocyfc	405	24	and	and	CC
cord-290566-tmsocyfc	405	25	suppressor	suppressor	VB
cord-290566-tmsocyfc	405	26	T	T	NNP
cord-290566-tmsocyfc	405	27	cell	cell	NN
cord-290566-tmsocyfc	405	28	clones	clone	NNS
cord-290566-tmsocyfc	405	29	Preferential	Preferential	NNP
cord-290566-tmsocyfc	405	30	T	t	NN
cord-290566-tmsocyfc	405	31	-	-	HYPH
cord-290566-tmsocyfc	405	32	cell	cell	NN
cord-290566-tmsocyfc	405	33	receptor	receptor	NN
cord-290566-tmsocyfc	406	1	beta	beta	NN
cord-290566-tmsocyfc	406	2	-	-	HYPH
cord-290566-tmsocyfc	406	3	chain	chain	NN
cord-290566-tmsocyfc	406	4	variable	variable	JJ
cord-290566-tmsocyfc	406	5	gene	gene	NN
cord-290566-tmsocyfc	406	6	use	use	NN
cord-290566-tmsocyfc	406	7	in	in	IN
cord-290566-tmsocyfc	406	8	myelin	myelin	JJ
cord-290566-tmsocyfc	406	9	basic	basic	JJ
cord-290566-tmsocyfc	406	10	protein	protein	NN
cord-290566-tmsocyfc	406	11	-	-	HYPH
cord-290566-tmsocyfc	406	12	reactive	reactive	JJ
cord-290566-tmsocyfc	406	13	T	t	NN
cord-290566-tmsocyfc	406	14	-	-	HYPH
cord-290566-tmsocyfc	406	15	cell	cell	NN
cord-290566-tmsocyfc	406	16	clones	clone	NNS
cord-290566-tmsocyfc	406	17	from	from	IN
cord-290566-tmsocyfc	406	18	patients	patient	NNS
cord-290566-tmsocyfc	406	19	with	with	IN
cord-290566-tmsocyfc	406	20	multiple	multiple	JJ
cord-290566-tmsocyfc	406	21	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	407	1	A	a	DT
cord-290566-tmsocyfc	407	2	PD-1	PD-1	NNP
cord-290566-tmsocyfc	407	3	polymorphism	polymorphism	NN
cord-290566-tmsocyfc	407	4	is	be	VBZ
cord-290566-tmsocyfc	407	5	associated	associate	VBN
cord-290566-tmsocyfc	407	6	with	with	IN
cord-290566-tmsocyfc	407	7	disease	disease	NN
cord-290566-tmsocyfc	407	8	progression	progression	NN
cord-290566-tmsocyfc	407	9	in	in	IN
cord-290566-tmsocyfc	407	10	multiple	multiple	JJ
cord-290566-tmsocyfc	407	11	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	407	12	DiVerences	diverence	NNS
cord-290566-tmsocyfc	407	13	in	in	IN
cord-290566-tmsocyfc	407	14	responsiveness	responsiveness	NN
cord-290566-tmsocyfc	407	15	to	to	IN
cord-290566-tmsocyfc	407	16	CD3	CD3	NNP
cord-290566-tmsocyfc	407	17	stimulation	stimulation	NN
cord-290566-tmsocyfc	407	18	between	between	IN
cord-290566-tmsocyfc	407	19	naive	naive	JJ
cord-290566-tmsocyfc	407	20	and	and	CC
cord-290566-tmsocyfc	407	21	memory	memory	NN
cord-290566-tmsocyfc	407	22	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	407	23	T	T	NNP
cord-290566-tmsocyfc	407	24	cells	cell	NNS
cord-290566-tmsocyfc	407	25	can	can	MD
cord-290566-tmsocyfc	407	26	not	not	RB
cord-290566-tmsocyfc	407	27	be	be	VB
cord-290566-tmsocyfc	407	28	overcome	overcome	VBN
cord-290566-tmsocyfc	407	29	by	by	IN
cord-290566-tmsocyfc	407	30	CD28	CD28	NNP
cord-290566-tmsocyfc	407	31	costimulation	costimulation	NNP
cord-290566-tmsocyfc	408	1	A	a	DT
cord-290566-tmsocyfc	408	2	functional	functional	JJ
cord-290566-tmsocyfc	408	3	and	and	CC
cord-290566-tmsocyfc	408	4	structural	structural	JJ
cord-290566-tmsocyfc	408	5	basis	basis	NN
cord-290566-tmsocyfc	408	6	for	for	IN
cord-290566-tmsocyfc	408	7	TCR	TCR	NNP
cord-290566-tmsocyfc	408	8	cross	cross	NN
cord-290566-tmsocyfc	408	9	-	-	NN
cord-290566-tmsocyfc	408	10	reactivity	reactivity	NN
cord-290566-tmsocyfc	408	11	in	in	IN
cord-290566-tmsocyfc	408	12	multiple	multiple	JJ
cord-290566-tmsocyfc	408	13	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	408	14	Progressive	progressive	JJ
cord-290566-tmsocyfc	408	15	multifocal	multifocal	JJ
cord-290566-tmsocyfc	408	16	leukoencephalopathy	leukoencephalopathy	NNS
cord-290566-tmsocyfc	408	17	in	in	IN
cord-290566-tmsocyfc	408	18	a	a	DT
cord-290566-tmsocyfc	408	19	patient	patient	NN
cord-290566-tmsocyfc	408	20	treated	treat	VBN
cord-290566-tmsocyfc	408	21	with	with	IN
cord-290566-tmsocyfc	408	22	natalizumab	natalizumab	NNS
cord-290566-tmsocyfc	408	23	IL-23	IL-23	NNP
cord-290566-tmsocyfc	408	24	drives	drive	VBZ
cord-290566-tmsocyfc	408	25	a	a	DT
cord-290566-tmsocyfc	408	26	pathogenic	pathogenic	JJ
cord-290566-tmsocyfc	408	27	T	t	NN
cord-290566-tmsocyfc	408	28	cell	cell	NN
cord-290566-tmsocyfc	408	29	population	population	NN
cord-290566-tmsocyfc	408	30	that	that	WDT
cord-290566-tmsocyfc	408	31	induces	induce	VBZ
cord-290566-tmsocyfc	408	32	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	408	33	inflammation	inflammation	NN
cord-290566-tmsocyfc	408	34	Functional	functional	JJ
cord-290566-tmsocyfc	408	35	and	and	CC
cord-290566-tmsocyfc	408	36	ontogenetic	ontogenetic	JJ
cord-290566-tmsocyfc	408	37	analysis	analysis	NN
cord-290566-tmsocyfc	408	38	of	of	IN
cord-290566-tmsocyfc	409	1	murine	murine	JJ
cord-290566-tmsocyfc	409	2	CD45Rhi	CD45Rhi	NNP
cord-290566-tmsocyfc	409	3	and	and	CC
cord-290566-tmsocyfc	409	4	CD45Rlo	cd45rlo	NN
cord-290566-tmsocyfc	409	5	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	409	6	T	T	NNP
cord-290566-tmsocyfc	409	7	cells	cell	NNS
cord-290566-tmsocyfc	409	8	Human	human	JJ
cord-290566-tmsocyfc	409	9	CD25þ	cd25þ	JJ
cord-290566-tmsocyfc	409	10	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	409	11	T	T	NNP
cord-290566-tmsocyfc	409	12	regulatory	regulatory	JJ
cord-290566-tmsocyfc	409	13	cells	cell	NNS
cord-290566-tmsocyfc	409	14	suppress	suppress	VBP
cord-290566-tmsocyfc	409	15	naive	naive	JJ
cord-290566-tmsocyfc	409	16	and	and	CC
cord-290566-tmsocyfc	409	17	memory	memory	NN
cord-290566-tmsocyfc	409	18	T	t	NN
cord-290566-tmsocyfc	409	19	cell	cell	NN
cord-290566-tmsocyfc	409	20	proliferation	proliferation	NN
cord-290566-tmsocyfc	409	21	and	and	CC
cord-290566-tmsocyfc	409	22	can	can	MD
cord-290566-tmsocyfc	409	23	be	be	VB
cord-290566-tmsocyfc	409	24	expanded	expand	VBN
cord-290566-tmsocyfc	409	25	in	in	IN
cord-290566-tmsocyfc	409	26	vitro	vitro	FW
cord-290566-tmsocyfc	409	27	without	without	IN
cord-290566-tmsocyfc	409	28	loss	loss	NN
cord-290566-tmsocyfc	409	29	of	of	IN
cord-290566-tmsocyfc	409	30	function	function	NN
cord-290566-tmsocyfc	410	1	The	the	DT
cord-290566-tmsocyfc	410	2	CTLA-4	CTLA-4	NNPS
cord-290566-tmsocyfc	410	3	gene	gene	NN
cord-290566-tmsocyfc	410	4	is	be	VBZ
cord-290566-tmsocyfc	410	5	associated	associate	VBN
cord-290566-tmsocyfc	410	6	with	with	IN
cord-290566-tmsocyfc	410	7	multiple	multiple	JJ
cord-290566-tmsocyfc	410	8	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	410	9	Neuron	Neuron	NNP
cord-290566-tmsocyfc	410	10	-	-	HYPH
cord-290566-tmsocyfc	410	11	mediated	mediate	VBN
cord-290566-tmsocyfc	410	12	generation	generation	NN
cord-290566-tmsocyfc	410	13	of	of	IN
cord-290566-tmsocyfc	410	14	regulatory	regulatory	JJ
cord-290566-tmsocyfc	410	15	T	t	NN
cord-290566-tmsocyfc	410	16	cells	cell	NNS
cord-290566-tmsocyfc	410	17	from	from	IN
cord-290566-tmsocyfc	410	18	encephalitogenic	encephalitogenic	NNP
cord-290566-tmsocyfc	410	19	T	T	NNP
cord-290566-tmsocyfc	410	20	cells	cell	NNS
cord-290566-tmsocyfc	410	21	suppresses	suppress	VBZ
cord-290566-tmsocyfc	410	22	EAE	EAE	NNP
cord-290566-tmsocyfc	410	23	Gene	Gene	NNP
cord-290566-tmsocyfc	410	24	-	-	HYPH
cord-290566-tmsocyfc	410	25	microarray	microarray	NN
cord-290566-tmsocyfc	410	26	analysis	analysis	NN
cord-290566-tmsocyfc	410	27	of	of	IN
cord-290566-tmsocyfc	410	28	multiple	multiple	JJ
cord-290566-tmsocyfc	410	29	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	410	30	lesions	lesion	NNS
cord-290566-tmsocyfc	410	31	yields	yield	VBZ
cord-290566-tmsocyfc	410	32	new	new	JJ
cord-290566-tmsocyfc	410	33	targets	target	NNS
cord-290566-tmsocyfc	410	34	validated	validate	VBN
cord-290566-tmsocyfc	410	35	in	in	IN
cord-290566-tmsocyfc	410	36	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	410	37	encephalomyelitis	encephalomyelitis	NN
cord-290566-tmsocyfc	410	38	T	T	NNP
cord-290566-tmsocyfc	410	39	cell	cell	NN
cord-290566-tmsocyfc	410	40	receptor	receptor	NN
cord-290566-tmsocyfc	410	41	V	V	NNP
cord-290566-tmsocyfc	410	42	5	5	CD
cord-290566-tmsocyfc	410	43	and	and	CC
cord-290566-tmsocyfc	410	44	V	V	NNP
cord-290566-tmsocyfc	410	45	17	17	CD
cord-290566-tmsocyfc	410	46	clonal	clonal	JJ
cord-290566-tmsocyfc	410	47	diversity	diversity	NN
cord-290566-tmsocyfc	410	48	in	in	IN
cord-290566-tmsocyfc	410	49	cerebrospinal	cerebrospinal	JJ
cord-290566-tmsocyfc	410	50	fluid	fluid	NN
cord-290566-tmsocyfc	410	51	and	and	CC
cord-290566-tmsocyfc	410	52	peripheral	peripheral	JJ
cord-290566-tmsocyfc	410	53	blood	blood	NN
cord-290566-tmsocyfc	410	54	lymphocytes	lymphocyte	NNS
cord-290566-tmsocyfc	410	55	of	of	IN
cord-290566-tmsocyfc	410	56	multiple	multiple	JJ
cord-290566-tmsocyfc	410	57	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	410	58	patients	patient	NNS
cord-290566-tmsocyfc	410	59	Heterogeneity	Heterogeneity	NNP
cord-290566-tmsocyfc	410	60	of	of	IN
cord-290566-tmsocyfc	410	61	multiple	multiple	JJ
cord-290566-tmsocyfc	410	62	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	410	63	lesions	lesion	NNS
cord-290566-tmsocyfc	410	64	:	:	:
cord-290566-tmsocyfc	411	1	Implications	implication	NNS
cord-290566-tmsocyfc	411	2	for	for	IN
cord-290566-tmsocyfc	411	3	the	the	DT
cord-290566-tmsocyfc	411	4	pathogenesis	pathogenesis	NN
cord-290566-tmsocyfc	411	5	of	of	IN
cord-290566-tmsocyfc	411	6	demyelination	demyelination	NN
cord-290566-tmsocyfc	411	7	Distinct	distinct	JJ
cord-290566-tmsocyfc	411	8	patterns	pattern	NNS
cord-290566-tmsocyfc	411	9	of	of	IN
cord-290566-tmsocyfc	411	10	multiple	multiple	JJ
cord-290566-tmsocyfc	411	11	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	411	12	pathology	pathology	NN
cord-290566-tmsocyfc	411	13	indicates	indicate	VBZ
cord-290566-tmsocyfc	411	14	heterogeneity	heterogeneity	NN
cord-290566-tmsocyfc	411	15	on	on	IN
cord-290566-tmsocyfc	411	16	pathogenesis	pathogenesis	NN
cord-290566-tmsocyfc	411	17	Transforming	transform	VBG
cord-290566-tmsocyfc	411	18	growth	growth	NN
cord-290566-tmsocyfc	411	19	factor	factor	NN
cord-290566-tmsocyfc	411	20	-	-	HYPH
cord-290566-tmsocyfc	411	21	beta	beta	NN
cord-290566-tmsocyfc	411	22	induces	induce	VBZ
cord-290566-tmsocyfc	411	23	development	development	NN
cord-290566-tmsocyfc	411	24	of	of	IN
cord-290566-tmsocyfc	411	25	the	the	DT
cord-290566-tmsocyfc	411	26	T(H)17	T(H)17	NNP
cord-290566-tmsocyfc	411	27	lineage	lineage	NN
cord-290566-tmsocyfc	411	28	T	t	NN
cord-290566-tmsocyfc	411	29	cell	cell	NN
cord-290566-tmsocyfc	411	30	recognition	recognition	NN
cord-290566-tmsocyfc	411	31	of	of	IN
cord-290566-tmsocyfc	411	32	immunodominant	immunodominant	JJ
cord-290566-tmsocyfc	411	33	and	and	CC
cord-290566-tmsocyfc	411	34	cryptic	cryptic	JJ
cord-290566-tmsocyfc	411	35	proteolipid	proteolipid	NN
cord-290566-tmsocyfc	411	36	protein	protein	NN
cord-290566-tmsocyfc	411	37	epitopes	epitope	NNS
cord-290566-tmsocyfc	411	38	in	in	IN
cord-290566-tmsocyfc	411	39	humans	human	NNS
cord-290566-tmsocyfc	411	40	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	411	41	CD28-costimulation	CD28-costimulation	NNP
cord-290566-tmsocyfc	411	42	-	-	HYPH
cord-290566-tmsocyfc	411	43	independent	independent	JJ
cord-290566-tmsocyfc	411	44	T	t	NN
cord-290566-tmsocyfc	411	45	cells	cell	NNS
cord-290566-tmsocyfc	411	46	in	in	IN
cord-290566-tmsocyfc	411	47	multiple	multiple	JJ
cord-290566-tmsocyfc	411	48	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	411	49	High	high	JJ
cord-290566-tmsocyfc	411	50	level	level	NN
cord-290566-tmsocyfc	411	51	of	of	IN
cord-290566-tmsocyfc	411	52	cross	cross	NN
cord-290566-tmsocyfc	411	53	-	-	NN
cord-290566-tmsocyfc	411	54	reactivity	reactivity	NN
cord-290566-tmsocyfc	411	55	in	in	IN
cord-290566-tmsocyfc	411	56	influenza	influenza	NN
cord-290566-tmsocyfc	411	57	virus	virus	NN
cord-290566-tmsocyfc	411	58	hemagglutinin	hemagglutinin	NN
cord-290566-tmsocyfc	411	59	-	-	HYPH
cord-290566-tmsocyfc	411	60	specific	specific	JJ
cord-290566-tmsocyfc	411	61	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	411	62	T	T	NNP
cord-290566-tmsocyfc	411	63	-	-	HYPH
cord-290566-tmsocyfc	411	64	cell	cell	NN
cord-290566-tmsocyfc	411	65	response	response	NN
cord-290566-tmsocyfc	411	66	:	:	:
cord-290566-tmsocyfc	411	67	Implications	implication	NNS
cord-290566-tmsocyfc	411	68	for	for	IN
cord-290566-tmsocyfc	411	69	the	the	DT
cord-290566-tmsocyfc	411	70	initiation	initiation	NN
cord-290566-tmsocyfc	411	71	of	of	IN
cord-290566-tmsocyfc	411	72	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	411	73	response	response	NN
cord-290566-tmsocyfc	411	74	in	in	IN
cord-290566-tmsocyfc	411	75	multiple	multiple	JJ
cord-290566-tmsocyfc	411	76	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	411	77	CTLA4	CTLA4	NNP
cord-290566-tmsocyfc	411	78	dimorphisms	dimorphism	NNS
cord-290566-tmsocyfc	411	79	and	and	CC
cord-290566-tmsocyfc	412	1	the	the	DT
cord-290566-tmsocyfc	412	2	multiple	multiple	JJ
cord-290566-tmsocyfc	412	3	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	412	4	phenotype	phenotype	NN
cord-290566-tmsocyfc	412	5	Epitope	Epitope	NNP
cord-290566-tmsocyfc	412	6	spreading	spreading	NN
cord-290566-tmsocyfc	412	7	initiates	initiate	NNS
cord-290566-tmsocyfc	412	8	in	in	IN
cord-290566-tmsocyfc	412	9	the	the	DT
cord-290566-tmsocyfc	412	10	CNS	CNS	NNP
cord-290566-tmsocyfc	412	11	in	in	IN
cord-290566-tmsocyfc	412	12	two	two	CD
cord-290566-tmsocyfc	412	13	mouse	mouse	NN
cord-290566-tmsocyfc	412	14	models	model	NNS
cord-290566-tmsocyfc	412	15	of	of	IN
cord-290566-tmsocyfc	412	16	multiple	multiple	JJ
cord-290566-tmsocyfc	412	17	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	412	18	Depletion	depletion	NN
cord-290566-tmsocyfc	412	19	of	of	IN
cord-290566-tmsocyfc	412	20	myelin	myelin	NN
cord-290566-tmsocyfc	412	21	-	-	HYPH
cord-290566-tmsocyfc	412	22	basicprotein	basicprotein	NNP
cord-290566-tmsocyfc	412	23	autoreactive	autoreactive	JJ
cord-290566-tmsocyfc	412	24	T	t	NN
cord-290566-tmsocyfc	412	25	cells	cell	NNS
cord-290566-tmsocyfc	412	26	by	by	IN
cord-290566-tmsocyfc	412	27	T	t	NN
cord-290566-tmsocyfc	412	28	-	-	HYPH
cord-290566-tmsocyfc	412	29	cell	cell	NN
cord-290566-tmsocyfc	412	30	vaccination	vaccination	NN
cord-290566-tmsocyfc	412	31	:	:	:
cord-290566-tmsocyfc	413	1	Pilot	pilot	NN
cord-290566-tmsocyfc	413	2	trial	trial	NN
cord-290566-tmsocyfc	413	3	in	in	IN
cord-290566-tmsocyfc	413	4	multiple	multiple	JJ
cord-290566-tmsocyfc	413	5	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	413	6	Transection	Transection	NNP
cord-290566-tmsocyfc	413	7	of	of	IN
cord-290566-tmsocyfc	413	8	major	major	JJ
cord-290566-tmsocyfc	413	9	histocompatibility	histocompatibility	NN
cord-290566-tmsocyfc	413	10	complex	complex	JJ
cord-290566-tmsocyfc	413	11	class	class	NN
cord-290566-tmsocyfc	413	12	I	i	NN
cord-290566-tmsocyfc	413	13	-	-	HYPH
cord-290566-tmsocyfc	413	14	induced	induce	VBN
cord-290566-tmsocyfc	413	15	neurites	neurite	NNS
cord-290566-tmsocyfc	413	16	by	by	IN
cord-290566-tmsocyfc	413	17	cytotoxic	cytotoxic	JJ
cord-290566-tmsocyfc	413	18	T	t	NN
cord-290566-tmsocyfc	413	19	lymphocytes	lymphocyte	NNS
cord-290566-tmsocyfc	413	20	Expression	expression	NN
cord-290566-tmsocyfc	413	21	of	of	IN
cord-290566-tmsocyfc	413	22	costimulatory	costimulatory	NN
cord-290566-tmsocyfc	413	23	molecules	molecule	NNS
cord-290566-tmsocyfc	413	24	on	on	IN
cord-290566-tmsocyfc	413	25	peripheral	peripheral	JJ
cord-290566-tmsocyfc	413	26	blood	blood	NN
cord-290566-tmsocyfc	413	27	mononuclear	mononuclear	NN
cord-290566-tmsocyfc	413	28	cells	cell	NNS
cord-290566-tmsocyfc	413	29	in	in	IN
cord-290566-tmsocyfc	413	30	multiple	multiple	JJ
cord-290566-tmsocyfc	413	31	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	413	32	TIM-4	TIM-4	NNP
cord-290566-tmsocyfc	413	33	is	be	VBZ
cord-290566-tmsocyfc	413	34	the	the	DT
cord-290566-tmsocyfc	413	35	ligand	ligand	NN
cord-290566-tmsocyfc	413	36	for	for	IN
cord-290566-tmsocyfc	413	37	TIM-1	TIM-1	NNP
cord-290566-tmsocyfc	413	38	,	,	,
cord-290566-tmsocyfc	413	39	and	and	CC
cord-290566-tmsocyfc	413	40	the	the	DT
cord-290566-tmsocyfc	413	41	TIM-1-TIM-4	TIM-1-TIM-4	NNP
cord-290566-tmsocyfc	413	42	interaction	interaction	NN
cord-290566-tmsocyfc	413	43	regulates	regulate	VBZ
cord-290566-tmsocyfc	413	44	T	T	NNP
cord-290566-tmsocyfc	413	45	cell	cell	NN
cord-290566-tmsocyfc	413	46	proliferation	proliferation	NN
cord-290566-tmsocyfc	413	47	A	a	DT
cord-290566-tmsocyfc	413	48	controlled	control	VBN
cord-290566-tmsocyfc	413	49	trial	trial	NN
cord-290566-tmsocyfc	413	50	of	of	IN
cord-290566-tmsocyfc	413	51	natalizumab	natalizumab	NNS
cord-290566-tmsocyfc	413	52	for	for	IN
cord-290566-tmsocyfc	413	53	relapsing	relapse	VBG
cord-290566-tmsocyfc	413	54	multiple	multiple	JJ
cord-290566-tmsocyfc	413	55	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	413	56	Persistent	persistent	JJ
cord-290566-tmsocyfc	413	57	infection	infection	NN
cord-290566-tmsocyfc	413	58	with	with	IN
cord-290566-tmsocyfc	413	59	Theiler	Theiler	NNP
cord-290566-tmsocyfc	413	60	's	's	POS
cord-290566-tmsocyfc	413	61	virus	virus	NN
cord-290566-tmsocyfc	413	62	leads	lead	VBZ
cord-290566-tmsocyfc	413	63	to	to	IN
cord-290566-tmsocyfc	413	64	CNS	CNS	NNP
cord-290566-tmsocyfc	413	65	autoimmunity	autoimmunity	NN
cord-290566-tmsocyfc	413	66	via	via	IN
cord-290566-tmsocyfc	413	67	epitope	epitope	NN
cord-290566-tmsocyfc	413	68	spreading	spread	VBG
cord-290566-tmsocyfc	413	69	Implication	implication	NN
cord-290566-tmsocyfc	413	70	of	of	IN
cord-290566-tmsocyfc	413	71	Th1	th1	NN
cord-290566-tmsocyfc	413	72	,	,	,
cord-290566-tmsocyfc	413	73	Th2	Th2	NNP
cord-290566-tmsocyfc	413	74	,	,	,
cord-290566-tmsocyfc	413	75	and	and	CC
cord-290566-tmsocyfc	413	76	Th3	th3	CD
cord-290566-tmsocyfc	413	77	cytokines	cytokine	NNS
cord-290566-tmsocyfc	413	78	in	in	IN
cord-290566-tmsocyfc	413	79	liver	liver	NN
cord-290566-tmsocyfc	413	80	graft	graft	NN
cord-290566-tmsocyfc	413	81	acceptance	acceptance	NN
cord-290566-tmsocyfc	413	82	Autoimmune	Autoimmune	NNP
cord-290566-tmsocyfc	413	83	T	T	NNP
cord-290566-tmsocyfc	413	84	cells	cell	NNS
cord-290566-tmsocyfc	413	85	protect	protect	VBP
cord-290566-tmsocyfc	413	86	neurons	neuron	NNS
cord-290566-tmsocyfc	413	87	from	from	IN
cord-290566-tmsocyfc	413	88	secondary	secondary	JJ
cord-290566-tmsocyfc	413	89	degeneration	degeneration	NN
cord-290566-tmsocyfc	413	90	after	after	IN
cord-290566-tmsocyfc	413	91	central	central	JJ
cord-290566-tmsocyfc	413	92	nervous	nervous	JJ
cord-290566-tmsocyfc	413	93	system	system	NN
cord-290566-tmsocyfc	413	94	axotomy	axotomy	NN
cord-290566-tmsocyfc	413	95	Production	production	NN
cord-290566-tmsocyfc	413	96	of	of	IN
cord-290566-tmsocyfc	413	97	neurotrophins	neurotrophins	NNP
cord-290566-tmsocyfc	413	98	by	by	IN
cord-290566-tmsocyfc	413	99	activated	activate	VBN
cord-290566-tmsocyfc	413	100	T	T	NNP
cord-290566-tmsocyfc	413	101	cells	cell	NNS
cord-290566-tmsocyfc	413	102	:	:	:
cord-290566-tmsocyfc	414	1	Implications	implication	NNS
cord-290566-tmsocyfc	414	2	for	for	IN
cord-290566-tmsocyfc	414	3	neuroprotective	neuroprotective	JJ
cord-290566-tmsocyfc	414	4	autoimmunity	autoimmunity	NN
cord-290566-tmsocyfc	414	5	Molecular	molecular	JJ
cord-290566-tmsocyfc	414	6	mimicry	mimicry	NN
cord-290566-tmsocyfc	414	7	between	between	IN
cord-290566-tmsocyfc	414	8	a	a	DT
cord-290566-tmsocyfc	414	9	viral	viral	JJ
cord-290566-tmsocyfc	414	10	peptide	peptide	NN
cord-290566-tmsocyfc	414	11	and	and	CC
cord-290566-tmsocyfc	414	12	a	a	DT
cord-290566-tmsocyfc	414	13	myelin	myelin	NN
cord-290566-tmsocyfc	414	14	oligodendrocyte	oligodendrocyte	NNP
cord-290566-tmsocyfc	414	15	glycoprotein	glycoprotein	NN
cord-290566-tmsocyfc	414	16	peptide	peptide	NN
cord-290566-tmsocyfc	414	17	induces	induce	VBZ
cord-290566-tmsocyfc	414	18	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	414	19	demyelinating	demyelinate	VBG
cord-290566-tmsocyfc	414	20	disease	disease	NN
cord-290566-tmsocyfc	414	21	in	in	IN
cord-290566-tmsocyfc	414	22	mice	mouse	NNS
cord-290566-tmsocyfc	414	23	Th1-specific	Th1-specific	NNP
cord-290566-tmsocyfc	414	24	cell	cell	NN
cord-290566-tmsocyfc	414	25	surface	surface	NN
cord-290566-tmsocyfc	414	26	protein	protein	NN
cord-290566-tmsocyfc	414	27	Tim-3	Tim-3	NNP
cord-290566-tmsocyfc	414	28	regulates	regulate	VBZ
cord-290566-tmsocyfc	414	29	macrophage	macrophage	NN
cord-290566-tmsocyfc	414	30	activation	activation	NN
cord-290566-tmsocyfc	414	31	and	and	CC
cord-290566-tmsocyfc	414	32	severity	severity	NN
cord-290566-tmsocyfc	414	33	of	of	IN
cord-290566-tmsocyfc	414	34	an	an	DT
cord-290566-tmsocyfc	414	35	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	414	36	disease	disease	NN
cord-290566-tmsocyfc	414	37	T	T	NNP
cord-290566-tmsocyfc	414	38	cell	cell	NN
cord-290566-tmsocyfc	414	39	response	response	NN
cord-290566-tmsocyfc	414	40	to	to	IN
cord-290566-tmsocyfc	414	41	2	2	CD
cord-290566-tmsocyfc	414	42	0	0	CD
cord-290566-tmsocyfc	414	43	,	,	,
cord-290566-tmsocyfc	414	44	3	3	CD
cord-290566-tmsocyfc	414	45	0	0	CD
cord-290566-tmsocyfc	414	46	-cyclic	-cyclic	NN
cord-290566-tmsocyfc	414	47	nucleotide	nucleotide	JJ
cord-290566-tmsocyfc	414	48	3	3	CD
cord-290566-tmsocyfc	414	49	0	0	CD
cord-290566-tmsocyfc	414	50	-phosphodiesterase	-phosphodiesterase	CD
cord-290566-tmsocyfc	415	1	(	(	-LRB-
cord-290566-tmsocyfc	415	2	CNPase	CNPase	NNP
cord-290566-tmsocyfc	415	3	)	)	-RRB-
cord-290566-tmsocyfc	415	4	in	in	IN
cord-290566-tmsocyfc	415	5	multiple	multiple	JJ
cord-290566-tmsocyfc	415	6	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	415	7	patients	patient	NNS
cord-290566-tmsocyfc	415	8	Thymic	Thymic	NNP
cord-290566-tmsocyfc	415	9	output	output	NN
cord-290566-tmsocyfc	415	10	generates	generate	VBZ
cord-290566-tmsocyfc	415	11	a	a	DT
cord-290566-tmsocyfc	415	12	new	new	JJ
cord-290566-tmsocyfc	415	13	and	and	CC
cord-290566-tmsocyfc	415	14	diverse	diverse	JJ
cord-290566-tmsocyfc	415	15	TCR	TCR	NNP
cord-290566-tmsocyfc	415	16	repertoire	repertoire	NN
cord-290566-tmsocyfc	415	17	after	after	IN
cord-290566-tmsocyfc	415	18	autologous	autologous	JJ
cord-290566-tmsocyfc	415	19	stem	stem	NN
cord-290566-tmsocyfc	415	20	cell	cell	NN
cord-290566-tmsocyfc	415	21	transplantation	transplantation	NN
cord-290566-tmsocyfc	415	22	in	in	IN
cord-290566-tmsocyfc	415	23	multiple	multiple	JJ
cord-290566-tmsocyfc	415	24	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	415	25	patients	patient	NNS
cord-290566-tmsocyfc	415	26	Expansion	Expansion	NNP
cord-290566-tmsocyfc	415	27	of	of	IN
cord-290566-tmsocyfc	415	28	a	a	DT
cord-290566-tmsocyfc	415	29	recurrent	recurrent	JJ
cord-290566-tmsocyfc	415	30	V	v	NN
cord-290566-tmsocyfc	415	31	5.3þ	5.3þ	CD
cord-290566-tmsocyfc	415	32	T	t	NN
cord-290566-tmsocyfc	415	33	-	-	HYPH
cord-290566-tmsocyfc	415	34	cell	cell	NN
cord-290566-tmsocyfc	415	35	population	population	NN
cord-290566-tmsocyfc	415	36	in	in	IN
cord-290566-tmsocyfc	415	37	newly	newly	RB
cord-290566-tmsocyfc	415	38	diagnosed	diagnose	VBN
cord-290566-tmsocyfc	415	39	and	and	CC
cord-290566-tmsocyfc	415	40	untreated	untreated	JJ
cord-290566-tmsocyfc	415	41	HLA	HLA	NNP
cord-290566-tmsocyfc	415	42	-	-	HYPH
cord-290566-tmsocyfc	415	43	DR2	DR2	NNP
cord-290566-tmsocyfc	415	44	multiple	multiple	JJ
cord-290566-tmsocyfc	415	45	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	415	46	patients	patient	NNS
cord-290566-tmsocyfc	415	47	Selection	Selection	NNP
cord-290566-tmsocyfc	415	48	for	for	IN
cord-290566-tmsocyfc	415	49	T	t	NN
cord-290566-tmsocyfc	415	50	-	-	HYPH
cord-290566-tmsocyfc	415	51	cell	cell	NN
cord-290566-tmsocyfc	415	52	receptor	receptor	NN
cord-290566-tmsocyfc	416	1	V	v	LS
cord-290566-tmsocyfc	416	2	beta	beta	NN
cord-290566-tmsocyfc	416	3	-	-	HYPH
cord-290566-tmsocyfc	416	4	D	d	JJ
cord-290566-tmsocyfc	416	5	beta	beta	NN
cord-290566-tmsocyfc	416	6	-	-	HYPH
cord-290566-tmsocyfc	416	7	J	j	NN
cord-290566-tmsocyfc	416	8	beta	beta	NN
cord-290566-tmsocyfc	416	9	gene	gene	NN
cord-290566-tmsocyfc	416	10	rearrangements	rearrangement	NNS
cord-290566-tmsocyfc	416	11	with	with	IN
cord-290566-tmsocyfc	416	12	specificity	specificity	NN
cord-290566-tmsocyfc	416	13	for	for	IN
cord-290566-tmsocyfc	416	14	a	a	DT
cord-290566-tmsocyfc	416	15	myelin	myelin	JJ
cord-290566-tmsocyfc	416	16	basic	basic	JJ
cord-290566-tmsocyfc	416	17	protein	protein	NN
cord-290566-tmsocyfc	416	18	peptide	peptide	NN
cord-290566-tmsocyfc	416	19	in	in	IN
cord-290566-tmsocyfc	416	20	brain	brain	NN
cord-290566-tmsocyfc	416	21	lesions	lesion	NNS
cord-290566-tmsocyfc	416	22	of	of	IN
cord-290566-tmsocyfc	416	23	multiple	multiple	JJ
cord-290566-tmsocyfc	416	24	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	416	25	CTLA-4	CTLA-4	NNS
cord-290566-tmsocyfc	416	26	dysregulation	dysregulation	NN
cord-290566-tmsocyfc	416	27	in	in	IN
cord-290566-tmsocyfc	416	28	the	the	DT
cord-290566-tmsocyfc	416	29	activation	activation	NN
cord-290566-tmsocyfc	416	30	of	of	IN
cord-290566-tmsocyfc	416	31	myelin	myelin	JJ
cord-290566-tmsocyfc	416	32	basic	basic	JJ
cord-290566-tmsocyfc	416	33	protein	protein	NN
cord-290566-tmsocyfc	416	34	reactive	reactive	JJ
cord-290566-tmsocyfc	416	35	T	t	NN
cord-290566-tmsocyfc	416	36	cells	cell	NNS
cord-290566-tmsocyfc	416	37	may	may	MD
cord-290566-tmsocyfc	416	38	distinguish	distinguish	VB
cord-290566-tmsocyfc	416	39	patients	patient	NNS
cord-290566-tmsocyfc	416	40	with	with	IN
cord-290566-tmsocyfc	416	41	multiple	multiple	JJ
cord-290566-tmsocyfc	416	42	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	416	43	from	from	IN
cord-290566-tmsocyfc	416	44	healthy	healthy	JJ
cord-290566-tmsocyfc	416	45	controls	control	NNS
cord-290566-tmsocyfc	417	1	A	a	DT
cord-290566-tmsocyfc	417	2	virusinduced	virusinduced	JJ
cord-290566-tmsocyfc	417	3	molecular	molecular	JJ
cord-290566-tmsocyfc	417	4	mimicry	mimicry	NN
cord-290566-tmsocyfc	417	5	model	model	NN
cord-290566-tmsocyfc	417	6	of	of	IN
cord-290566-tmsocyfc	417	7	multiple	multiple	JJ
cord-290566-tmsocyfc	417	8	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	417	9	Depletion	depletion	NN
cord-290566-tmsocyfc	417	10	of	of	IN
cord-290566-tmsocyfc	417	11	V	v	NN
cord-290566-tmsocyfc	417	12	5.2/5.3	5.2/5.3	CD
cord-290566-tmsocyfc	417	13	T	t	NN
cord-290566-tmsocyfc	417	14	cells	cell	NNS
cord-290566-tmsocyfc	417	15	with	with	IN
cord-290566-tmsocyfc	417	16	a	a	DT
cord-290566-tmsocyfc	417	17	humanized	humanized	JJ
cord-290566-tmsocyfc	417	18	antibody	antibody	NN
cord-290566-tmsocyfc	417	19	in	in	IN
cord-290566-tmsocyfc	417	20	patients	patient	NNS
cord-290566-tmsocyfc	417	21	with	with	IN
cord-290566-tmsocyfc	417	22	multiple	multiple	JJ
cord-290566-tmsocyfc	417	23	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	417	24	Stat6-independent	Stat6-independent	NNP
cord-290566-tmsocyfc	417	25	GATA-3	GATA-3	NNP
cord-290566-tmsocyfc	417	26	autoactivation	autoactivation	NN
cord-290566-tmsocyfc	417	27	directs	direct	VBZ
cord-290566-tmsocyfc	417	28	IL-4-independent	il-4-independent	NN
cord-290566-tmsocyfc	417	29	Th2	th2	CD
cord-290566-tmsocyfc	417	30	development	development	NN
cord-290566-tmsocyfc	417	31	and	and	CC
cord-290566-tmsocyfc	417	32	commitment	commitment	NN
cord-290566-tmsocyfc	417	33	Exacerbations	Exacerbations	NNPS
cord-290566-tmsocyfc	417	34	of	of	IN
cord-290566-tmsocyfc	417	35	multiple	multiple	JJ
cord-290566-tmsocyfc	417	36	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	417	37	in	in	IN
cord-290566-tmsocyfc	417	38	patients	patient	NNS
cord-290566-tmsocyfc	417	39	treated	treat	VBN
cord-290566-tmsocyfc	417	40	with	with	IN
cord-290566-tmsocyfc	417	41	gamma	gamma	NN
cord-290566-tmsocyfc	417	42	interferon	interferon	NN
cord-290566-tmsocyfc	417	43	Treatment	Treatment	NNP
cord-290566-tmsocyfc	417	44	of	of	IN
cord-290566-tmsocyfc	417	45	multiple	multiple	JJ
cord-290566-tmsocyfc	417	46	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	417	47	with	with	IN
cord-290566-tmsocyfc	417	48	gamma	gamma	NN
cord-290566-tmsocyfc	417	49	interferon	interferon	NN
cord-290566-tmsocyfc	417	50	:	:	:
cord-290566-tmsocyfc	418	1	Exacerbations	exacerbation	NNS
cord-290566-tmsocyfc	418	2	associated	associate	VBN
cord-290566-tmsocyfc	418	3	with	with	IN
cord-290566-tmsocyfc	418	4	activation	activation	NN
cord-290566-tmsocyfc	418	5	of	of	IN
cord-290566-tmsocyfc	418	6	the	the	DT
cord-290566-tmsocyfc	418	7	immune	immune	JJ
cord-290566-tmsocyfc	418	8	system	system	NN
cord-290566-tmsocyfc	419	1	A	a	DT
cord-290566-tmsocyfc	419	2	distinct	distinct	JJ
cord-290566-tmsocyfc	419	3	lineage	lineage	NN
cord-290566-tmsocyfc	419	4	of	of	IN
cord-290566-tmsocyfc	419	5	CD4	CD4	NNP
cord-290566-tmsocyfc	419	6	T	T	NNP
cord-290566-tmsocyfc	419	7	cells	cell	NNS
cord-290566-tmsocyfc	419	8	regulates	regulate	VBZ
cord-290566-tmsocyfc	419	9	tissue	tissue	NN
cord-290566-tmsocyfc	419	10	inflammation	inflammation	NN
cord-290566-tmsocyfc	419	11	by	by	IN
cord-290566-tmsocyfc	419	12	producing	produce	VBG
cord-290566-tmsocyfc	419	13	interleukin	interleukin	NN
cord-290566-tmsocyfc	419	14	17	17	CD
cord-290566-tmsocyfc	419	15	Identification	identification	NN
cord-290566-tmsocyfc	419	16	of	of	IN
cord-290566-tmsocyfc	419	17	a	a	DT
cord-290566-tmsocyfc	419	18	second	second	JJ
cord-290566-tmsocyfc	419	19	T	T	NNP
cord-290566-tmsocyfc	419	20	cell	cell	NN
cord-290566-tmsocyfc	419	21	epitope	epitope	NN
cord-290566-tmsocyfc	419	22	of	of	IN
cord-290566-tmsocyfc	419	23	human	human	JJ
cord-290566-tmsocyfc	419	24	proteolipid	proteolipid	NN
cord-290566-tmsocyfc	419	25	protein	protein	NNP
cord-290566-tmsocyfc	419	26	(	(	-LRB-
cord-290566-tmsocyfc	419	27	residues	residue	NNS
cord-290566-tmsocyfc	419	28	89	89	CD
cord-290566-tmsocyfc	419	29	-	-	SYM
cord-290566-tmsocyfc	419	30	106	106	CD
cord-290566-tmsocyfc	419	31	)	)	-RRB-
cord-290566-tmsocyfc	419	32	recognized	recognize	VBN
cord-290566-tmsocyfc	419	33	by	by	IN
cord-290566-tmsocyfc	419	34	proliferative	proliferative	JJ
cord-290566-tmsocyfc	419	35	and	and	CC
cord-290566-tmsocyfc	419	36	cytolytic	cytolytic	JJ
cord-290566-tmsocyfc	419	37	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	419	38	T	T	NNP
cord-290566-tmsocyfc	419	39	cells	cell	NNS
cord-290566-tmsocyfc	419	40	from	from	IN
cord-290566-tmsocyfc	419	41	multiple	multiple	JJ
cord-290566-tmsocyfc	419	42	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	419	43	patients	patient	NNS
cord-290566-tmsocyfc	420	1	Myelin	myelin	JJ
cord-290566-tmsocyfc	420	2	basic	basic	JJ
cord-290566-tmsocyfc	420	3	protein	protein	NN
cord-290566-tmsocyfc	420	4	reactive	reactive	JJ
cord-290566-tmsocyfc	420	5	Th2	Th2	NNP
cord-290566-tmsocyfc	420	6	T	t	NN
cord-290566-tmsocyfc	420	7	cells	cell	NNS
cord-290566-tmsocyfc	420	8	are	be	VBP
cord-290566-tmsocyfc	420	9	found	find	VBN
cord-290566-tmsocyfc	420	10	in	in	IN
cord-290566-tmsocyfc	420	11	acute	acute	JJ
cord-290566-tmsocyfc	420	12	disseminated	disseminate	VBN
cord-290566-tmsocyfc	420	13	encephalomyelitis	encephalomyelitis	NN
cord-290566-tmsocyfc	420	14	Macrophages	macrophage	NNS
cord-290566-tmsocyfc	420	15	,	,	,
cord-290566-tmsocyfc	420	16	lymphocytes	lymphocyte	NNS
cord-290566-tmsocyfc	420	17	,	,	,
cord-290566-tmsocyfc	420	18	and	and	CC
cord-290566-tmsocyfc	420	19	plasma	plasma	NN
cord-290566-tmsocyfc	420	20	cells	cell	NNS
cord-290566-tmsocyfc	420	21	in	in	IN
cord-290566-tmsocyfc	420	22	the	the	DT
cord-290566-tmsocyfc	420	23	perivascular	perivascular	NNP
cord-290566-tmsocyfc	420	24	compartment	compartment	NN
cord-290566-tmsocyfc	420	25	in	in	IN
cord-290566-tmsocyfc	420	26	chronic	chronic	JJ
cord-290566-tmsocyfc	420	27	multiple	multiple	JJ
cord-290566-tmsocyfc	420	28	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	420	29	Copolymer-1-induced	copolymer-1-induce	VBN
cord-290566-tmsocyfc	420	30	inhibition	inhibition	NN
cord-290566-tmsocyfc	420	31	of	of	IN
cord-290566-tmsocyfc	420	32	antigen	antigen	NN
cord-290566-tmsocyfc	420	33	-	-	HYPH
cord-290566-tmsocyfc	420	34	specific	specific	JJ
cord-290566-tmsocyfc	420	35	T	T	NNP
cord-290566-tmsocyfc	420	36	cell	cell	NN
cord-290566-tmsocyfc	420	37	activation	activation	NN
cord-290566-tmsocyfc	420	38	:	:	:
cord-290566-tmsocyfc	420	39	Interference	interference	NN
cord-290566-tmsocyfc	420	40	with	with	IN
cord-290566-tmsocyfc	420	41	antigen	antigen	NN
cord-290566-tmsocyfc	420	42	presentation	presentation	NN
cord-290566-tmsocyfc	421	1	The	the	DT
cord-290566-tmsocyfc	421	2	Dale	Dale	NNP
cord-290566-tmsocyfc	421	3	E.	E.	NNP
cord-290566-tmsocyfc	421	4	McFarlin	McFarlin	NNP
cord-290566-tmsocyfc	421	5	Memorial	Memorial	NNP
cord-290566-tmsocyfc	421	6	Lecture	Lecture	NNP
cord-290566-tmsocyfc	421	7	:	:	:
cord-290566-tmsocyfc	422	1	The	the	DT
cord-290566-tmsocyfc	422	2	immunology	immunology	NN
cord-290566-tmsocyfc	422	3	of	of	IN
cord-290566-tmsocyfc	422	4	the	the	DT
cord-290566-tmsocyfc	422	5	multiple	multiple	JJ
cord-290566-tmsocyfc	422	6	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	422	7	lesion	lesion	NN
cord-290566-tmsocyfc	422	8	Absence	absence	NN
cord-290566-tmsocyfc	422	9	of	of	IN
cord-290566-tmsocyfc	422	10	neurological	neurological	JJ
cord-290566-tmsocyfc	422	11	deficits	deficit	NNS
cord-290566-tmsocyfc	422	12	following	follow	VBG
cord-290566-tmsocyfc	422	13	extensive	extensive	JJ
cord-290566-tmsocyfc	422	14	demyelination	demyelination	NN
cord-290566-tmsocyfc	422	15	in	in	IN
cord-290566-tmsocyfc	422	16	a	a	DT
cord-290566-tmsocyfc	422	17	class	class	NN
cord-290566-tmsocyfc	422	18	I	i	NN
cord-290566-tmsocyfc	422	19	-	-	HYPH
cord-290566-tmsocyfc	422	20	deficient	deficient	JJ
cord-290566-tmsocyfc	422	21	murine	murine	JJ
cord-290566-tmsocyfc	422	22	model	model	NN
cord-290566-tmsocyfc	422	23	of	of	IN
cord-290566-tmsocyfc	422	24	multiple	multiple	JJ
cord-290566-tmsocyfc	422	25	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	423	1	The	the	DT
cord-290566-tmsocyfc	423	2	balance	balance	NN
cord-290566-tmsocyfc	423	3	between	between	IN
cord-290566-tmsocyfc	423	4	persistent	persistent	JJ
cord-290566-tmsocyfc	423	5	virus	virus	NN
cord-290566-tmsocyfc	423	6	infection	infection	NN
cord-290566-tmsocyfc	423	7	and	and	CC
cord-290566-tmsocyfc	423	8	immune	immune	JJ
cord-290566-tmsocyfc	423	9	cells	cell	NNS
cord-290566-tmsocyfc	423	10	determines	determine	VBZ
cord-290566-tmsocyfc	423	11	demyelination	demyelination	NN
cord-290566-tmsocyfc	424	1	The	the	DT
cord-290566-tmsocyfc	424	2	role	role	NN
cord-290566-tmsocyfc	424	3	of	of	IN
cord-290566-tmsocyfc	424	4	diVerent	diVerent	NNP
cord-290566-tmsocyfc	424	5	subsets	subset	NNS
cord-290566-tmsocyfc	424	6	of	of	IN
cord-290566-tmsocyfc	424	7	T	T	NNP
cord-290566-tmsocyfc	424	8	regulatory	regulatory	JJ
cord-290566-tmsocyfc	424	9	cells	cell	NNS
cord-290566-tmsocyfc	424	10	in	in	IN
cord-290566-tmsocyfc	424	11	controlling	control	VBG
cord-290566-tmsocyfc	424	12	autoimmunity	autoimmunity	IN
cord-290566-tmsocyfc	424	13	Interaction	Interaction	NNP
cord-290566-tmsocyfc	424	14	of	of	IN
cord-290566-tmsocyfc	424	15	Tim-3	Tim-3	NNP
cord-290566-tmsocyfc	424	16	and	and	CC
cord-290566-tmsocyfc	424	17	Tim-3	Tim-3	NNP
cord-290566-tmsocyfc	424	18	THE	the	DT
cord-290566-tmsocyfc	424	19	ROLE	role	NN
cord-290566-tmsocyfc	424	20	OF	of	IN
cord-290566-tmsocyfc	424	21	CD4	CD4	NNP
cord-290566-tmsocyfc	424	22	T	T	NNP
cord-290566-tmsocyfc	424	23	CELLS	cell	VBN
cord-290566-tmsocyfc	424	24	IN	in	IN
cord-290566-tmsocyfc	424	25	THE	the	DT
cord-290566-tmsocyfc	424	26	PATHOGENESIS	PATHOGENESIS	NNP
cord-290566-tmsocyfc	424	27	69	69	CD
cord-290566-tmsocyfc	424	28	ligand	ligand	NN
cord-290566-tmsocyfc	424	29	regulates	regulate	VBZ
cord-290566-tmsocyfc	424	30	T	T	NNP
cord-290566-tmsocyfc	424	31	helper	helper	NN
cord-290566-tmsocyfc	424	32	type	type	NN
cord-290566-tmsocyfc	424	33	1	1	CD
cord-290566-tmsocyfc	424	34	responses	response	NNS
cord-290566-tmsocyfc	424	35	and	and	CC
cord-290566-tmsocyfc	424	36	induction	induction	NN
cord-290566-tmsocyfc	424	37	of	of	IN
cord-290566-tmsocyfc	424	38	peripheral	peripheral	JJ
cord-290566-tmsocyfc	424	39	tolerance	tolerance	NN
cord-290566-tmsocyfc	425	1	In	in	IN
cord-290566-tmsocyfc	425	2	vitro	vitro	FW
cord-290566-tmsocyfc	425	3	evidence	evidence	NN
cord-290566-tmsocyfc	425	4	that	that	IN
cord-290566-tmsocyfc	425	5	subcutaneous	subcutaneous	JJ
cord-290566-tmsocyfc	425	6	administration	administration	NN
cord-290566-tmsocyfc	425	7	of	of	IN
cord-290566-tmsocyfc	425	8	glatiramer	glatiramer	NNP
cord-290566-tmsocyfc	425	9	acetate	acetate	NNP
cord-290566-tmsocyfc	425	10	induces	induce	VBZ
cord-290566-tmsocyfc	425	11	hyporesponsive	hyporesponsive	NNP
cord-290566-tmsocyfc	425	12	T	T	NNP
cord-290566-tmsocyfc	425	13	cells	cell	NNS
cord-290566-tmsocyfc	425	14	in	in	IN
cord-290566-tmsocyfc	425	15	patients	patient	NNS
cord-290566-tmsocyfc	425	16	with	with	IN
cord-290566-tmsocyfc	425	17	multiple	multiple	JJ
cord-290566-tmsocyfc	425	18	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	425	19	Expansion	Expansion	NNP
cord-290566-tmsocyfc	425	20	of	of	IN
cord-290566-tmsocyfc	425	21	autoreactive	autoreactive	NNP
cord-290566-tmsocyfc	425	22	T	t	NN
cord-290566-tmsocyfc	425	23	cells	cell	NNS
cord-290566-tmsocyfc	425	24	in	in	IN
cord-290566-tmsocyfc	425	25	multiple	multiple	JJ
cord-290566-tmsocyfc	425	26	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	425	27	is	be	VBZ
cord-290566-tmsocyfc	425	28	independent	independent	JJ
cord-290566-tmsocyfc	425	29	of	of	IN
cord-290566-tmsocyfc	425	30	exogenous	exogenous	JJ
cord-290566-tmsocyfc	425	31	B7	B7	NNP
cord-290566-tmsocyfc	425	32	costimulation	costimulation	NN
cord-290566-tmsocyfc	426	1	Polymorphisms	polymorphism	NNS
cord-290566-tmsocyfc	426	2	in	in	IN
cord-290566-tmsocyfc	426	3	the	the	DT
cord-290566-tmsocyfc	426	4	genes	gene	NNS
cord-290566-tmsocyfc	426	5	encoding	encode	VBG
cord-290566-tmsocyfc	426	6	interferongamma	interferongamma	NN
cord-290566-tmsocyfc	426	7	and	and	CC
cord-290566-tmsocyfc	426	8	interferon	interferon	NN
cord-290566-tmsocyfc	426	9	-	-	HYPH
cord-290566-tmsocyfc	426	10	gamma	gamma	NN
cord-290566-tmsocyfc	426	11	receptors	receptor	NNS
cord-290566-tmsocyfc	426	12	in	in	IN
cord-290566-tmsocyfc	426	13	multiple	multiple	JJ
cord-290566-tmsocyfc	426	14	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	426	15	Identification	identification	NN
cord-290566-tmsocyfc	426	16	of	of	IN
cord-290566-tmsocyfc	426	17	lymphotoxin	lymphotoxin	NN
cord-290566-tmsocyfc	426	18	and	and	CC
cord-290566-tmsocyfc	426	19	tumor	tumor	NN
cord-290566-tmsocyfc	426	20	necrosis	necrosis	NN
cord-290566-tmsocyfc	426	21	factor	factor	NN
cord-290566-tmsocyfc	426	22	in	in	IN
cord-290566-tmsocyfc	426	23	multiple	multiple	JJ
cord-290566-tmsocyfc	426	24	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	426	25	lesions	lesion	NNS
cord-290566-tmsocyfc	426	26	Expression	expression	NN
cord-290566-tmsocyfc	426	27	of	of	IN
cord-290566-tmsocyfc	426	28	chemokine	chemokine	NN
cord-290566-tmsocyfc	426	29	receptor	receptor	NN
cord-290566-tmsocyfc	426	30	CXCR3	CXCR3	VBN
cord-290566-tmsocyfc	426	31	on	on	IN
cord-290566-tmsocyfc	426	32	cerebrospinal	cerebrospinal	JJ
cord-290566-tmsocyfc	426	33	fluid	fluid	JJ
cord-290566-tmsocyfc	426	34	T	t	NN
cord-290566-tmsocyfc	426	35	-	-	HYPH
cord-290566-tmsocyfc	426	36	cells	cell	NNS
cord-290566-tmsocyfc	426	37	is	be	VBZ
cord-290566-tmsocyfc	426	38	related	relate	VBN
cord-290566-tmsocyfc	426	39	to	to	IN
cord-290566-tmsocyfc	426	40	active	active	JJ
cord-290566-tmsocyfc	426	41	MRI	MRI	NNP
cord-290566-tmsocyfc	426	42	lesion	lesion	NN
cord-290566-tmsocyfc	426	43	appearance	appearance	NN
cord-290566-tmsocyfc	426	44	in	in	IN
cord-290566-tmsocyfc	426	45	patients	patient	NNS
cord-290566-tmsocyfc	426	46	with	with	IN
cord-290566-tmsocyfc	426	47	relapsing	relapse	VBG
cord-290566-tmsocyfc	426	48	-	-	HYPH
cord-290566-tmsocyfc	426	49	remitting	remit	VBG
cord-290566-tmsocyfc	426	50	multiple	multiple	JJ
cord-290566-tmsocyfc	426	51	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	426	52	Immune	immune	NN
cord-290566-tmsocyfc	426	53	deviation	deviation	NN
cord-290566-tmsocyfc	426	54	following	follow	VBG
cord-290566-tmsocyfc	426	55	pulse	pulse	NN
cord-290566-tmsocyfc	426	56	cyclophosphamide	cyclophosphamide	RB
cord-290566-tmsocyfc	426	57	/	/	SYM
cord-290566-tmsocyfc	426	58	methylprednisolone	methylprednisolone	NN
cord-290566-tmsocyfc	426	59	treatment	treatment	NN
cord-290566-tmsocyfc	426	60	of	of	IN
cord-290566-tmsocyfc	426	61	multiple	multiple	JJ
cord-290566-tmsocyfc	426	62	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	426	63	:	:	:
cord-290566-tmsocyfc	426	64	Increased	increase	VBN
cord-290566-tmsocyfc	426	65	interleukin-4	interleukin-4	NNP
cord-290566-tmsocyfc	426	66	production	production	NN
cord-290566-tmsocyfc	426	67	and	and	CC
cord-290566-tmsocyfc	426	68	associated	associate	VBD
cord-290566-tmsocyfc	426	69	eosinophilia	eosinophilia	NNP
cord-290566-tmsocyfc	426	70	Autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	426	71	encephalomyelitis	encephalomyelitis	NN
cord-290566-tmsocyfc	426	72	ameliorated	ameliorate	VBN
cord-290566-tmsocyfc	426	73	by	by	IN
cord-290566-tmsocyfc	426	74	AMPA	AMPA	NNP
cord-290566-tmsocyfc	426	75	antagonists	antagonist	NNS
cord-290566-tmsocyfc	426	76	T	T	NNP
cord-290566-tmsocyfc	426	77	cell	cell	NN
cord-290566-tmsocyfc	426	78	memory	memory	NN
cord-290566-tmsocyfc	426	79	Human	Human	NNP
cord-290566-tmsocyfc	426	80	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	426	81	CD25þ	CD25þ	NNP
cord-290566-tmsocyfc	426	82	thymocytes	thymocyte	NNS
cord-290566-tmsocyfc	426	83	and	and	CC
cord-290566-tmsocyfc	426	84	peripheral	peripheral	JJ
cord-290566-tmsocyfc	426	85	T	t	NN
cord-290566-tmsocyfc	426	86	cells	cell	NNS
cord-290566-tmsocyfc	426	87	have	have	VBP
cord-290566-tmsocyfc	426	88	immune	immune	JJ
cord-290566-tmsocyfc	426	89	suppressive	suppressive	JJ
cord-290566-tmsocyfc	426	90	activity	activity	NN
cord-290566-tmsocyfc	426	91	in	in	IN
cord-290566-tmsocyfc	426	92	vitro	vitro	FW
cord-290566-tmsocyfc	426	93	Characteristics	characteristic	NNS
cord-290566-tmsocyfc	426	94	of	of	IN
cord-290566-tmsocyfc	426	95	T	T	NNP
cord-290566-tmsocyfc	426	96	-	-	HYPH
cord-290566-tmsocyfc	426	97	cell	cell	NN
cord-290566-tmsocyfc	426	98	receptor	receptor	NN
cord-290566-tmsocyfc	426	99	repertoire	repertoire	NN
cord-290566-tmsocyfc	426	100	and	and	CC
cord-290566-tmsocyfc	426	101	myelinreactive	myelinreactive	NNP
cord-290566-tmsocyfc	426	102	T	T	NNP
cord-290566-tmsocyfc	426	103	cells	cell	NNS
cord-290566-tmsocyfc	426	104	reconstituted	reconstitute	VBN
cord-290566-tmsocyfc	426	105	from	from	IN
cord-290566-tmsocyfc	426	106	autologous	autologous	JJ
cord-290566-tmsocyfc	426	107	haematopoietic	haematopoietic	JJ
cord-290566-tmsocyfc	426	108	stem	stem	NN
cord-290566-tmsocyfc	426	109	-	-	HYPH
cord-290566-tmsocyfc	426	110	cell	cell	NN
cord-290566-tmsocyfc	426	111	grafts	graft	NNS
cord-290566-tmsocyfc	426	112	in	in	IN
cord-290566-tmsocyfc	426	113	multiple	multiple	JJ
cord-290566-tmsocyfc	426	114	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	427	1	A	a	DT
cord-290566-tmsocyfc	427	2	novel	novel	NN
cord-290566-tmsocyfc	427	3	transcription	transcription	NN
cord-290566-tmsocyfc	427	4	factor	factor	NN
cord-290566-tmsocyfc	427	5	,	,	,
cord-290566-tmsocyfc	427	6	T	t	NN
cord-290566-tmsocyfc	427	7	-	-	HYPH
cord-290566-tmsocyfc	427	8	bet	bet	NN
cord-290566-tmsocyfc	427	9	,	,	,
cord-290566-tmsocyfc	427	10	directs	direct	VBZ
cord-290566-tmsocyfc	427	11	Th1	th1	NN
cord-290566-tmsocyfc	427	12	lineage	lineage	NN
cord-290566-tmsocyfc	427	13	commitment	commitment	NN
cord-290566-tmsocyfc	428	1	Impaired	impaired	JJ
cord-290566-tmsocyfc	428	2	IL-13-mediated	il-13-mediated	JJ
cord-290566-tmsocyfc	428	3	functions	function	NNS
cord-290566-tmsocyfc	428	4	of	of	IN
cord-290566-tmsocyfc	428	5	macrophages	macrophage	NNS
cord-290566-tmsocyfc	428	6	in	in	IN
cord-290566-tmsocyfc	428	7	STAT6-deficient	stat6-deficient	CD
cord-290566-tmsocyfc	428	8	mice	mouse	NNS
cord-290566-tmsocyfc	429	1	Myelin	myelin	JJ
cord-290566-tmsocyfc	429	2	basic	basic	JJ
cord-290566-tmsocyfc	429	3	protein	protein	NN
cord-290566-tmsocyfc	429	4	and	and	CC
cord-290566-tmsocyfc	429	5	human	human	JJ
cord-290566-tmsocyfc	429	6	coronavirus	coronavirus	NN
cord-290566-tmsocyfc	429	7	229E	229e	CD
cord-290566-tmsocyfc	429	8	cross	cross	JJ
cord-290566-tmsocyfc	429	9	-	-	JJ
cord-290566-tmsocyfc	429	10	reactive	reactive	JJ
cord-290566-tmsocyfc	429	11	T	t	NN
cord-290566-tmsocyfc	429	12	cells	cell	NNS
cord-290566-tmsocyfc	429	13	in	in	IN
cord-290566-tmsocyfc	429	14	multiple	multiple	JJ
cord-290566-tmsocyfc	429	15	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	429	16	Cross	cross	NN
cord-290566-tmsocyfc	429	17	-	-	NN
cord-290566-tmsocyfc	429	18	reactivity	reactivity	NN
cord-290566-tmsocyfc	429	19	with	with	IN
cord-290566-tmsocyfc	429	20	myelin	myelin	JJ
cord-290566-tmsocyfc	429	21	basic	basic	JJ
cord-290566-tmsocyfc	429	22	protein	protein	NN
cord-290566-tmsocyfc	429	23	and	and	CC
cord-290566-tmsocyfc	429	24	human	human	JJ
cord-290566-tmsocyfc	429	25	herpesvirus-6	herpesvirus-6	NNP
cord-290566-tmsocyfc	429	26	in	in	IN
cord-290566-tmsocyfc	429	27	multiple	multiple	JJ
cord-290566-tmsocyfc	429	28	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	430	1	Elevated	Elevated	NNP
cord-290566-tmsocyfc	430	2	CD40	CD40	NNP
cord-290566-tmsocyfc	430	3	ligand	ligand	NN
cord-290566-tmsocyfc	430	4	expressing	express	VBG
cord-290566-tmsocyfc	430	5	blood	blood	NN
cord-290566-tmsocyfc	430	6	T	t	NN
cord-290566-tmsocyfc	430	7	-	-	HYPH
cord-290566-tmsocyfc	430	8	cell	cell	NN
cord-290566-tmsocyfc	430	9	levels	level	NNS
cord-290566-tmsocyfc	430	10	in	in	IN
cord-290566-tmsocyfc	430	11	multiple	multiple	JJ
cord-290566-tmsocyfc	430	12	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	430	13	are	be	VBP
cord-290566-tmsocyfc	430	14	reversed	reverse	VBN
cord-290566-tmsocyfc	430	15	by	by	IN
cord-290566-tmsocyfc	430	16	interferon	interferon	NN
cord-290566-tmsocyfc	430	17	-	-	HYPH
cord-290566-tmsocyfc	430	18	beta	beta	NN
cord-290566-tmsocyfc	430	19	treatment	treatment	NN
cord-290566-tmsocyfc	430	20	Requirement	Requirement	NNP
cord-290566-tmsocyfc	430	21	for	for	IN
cord-290566-tmsocyfc	430	22	Stat4	Stat4	NNS
cord-290566-tmsocyfc	430	23	in	in	IN
cord-290566-tmsocyfc	431	1	interleukin-12-mediated	interleukin-12-mediated	JJ
cord-290566-tmsocyfc	431	2	responses	response	NNS
cord-290566-tmsocyfc	431	3	of	of	IN
cord-290566-tmsocyfc	431	4	natural	natural	JJ
cord-290566-tmsocyfc	431	5	killer	killer	NN
cord-290566-tmsocyfc	431	6	and	and	CC
cord-290566-tmsocyfc	431	7	T	t	NN
cord-290566-tmsocyfc	431	8	cells	cell	NNS
cord-290566-tmsocyfc	431	9	Axonal	axonal	JJ
cord-290566-tmsocyfc	431	10	transection	transection	NN
cord-290566-tmsocyfc	431	11	in	in	IN
cord-290566-tmsocyfc	431	12	the	the	DT
cord-290566-tmsocyfc	431	13	lesions	lesion	NNS
cord-290566-tmsocyfc	431	14	of	of	IN
cord-290566-tmsocyfc	431	15	multiple	multiple	JJ
cord-290566-tmsocyfc	431	16	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	431	17	Axonal	Axonal	NNP
cord-290566-tmsocyfc	431	18	pathology	pathology	NN
cord-290566-tmsocyfc	431	19	in	in	IN
cord-290566-tmsocyfc	431	20	multiple	multiple	JJ
cord-290566-tmsocyfc	431	21	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	431	22	:	:	:
cord-290566-tmsocyfc	431	23	Relationship	relationship	NN
cord-290566-tmsocyfc	431	24	to	to	IN
cord-290566-tmsocyfc	431	25	neurologic	neurologic	JJ
cord-290566-tmsocyfc	431	26	disability	disability	NN
cord-290566-tmsocyfc	431	27	Multiple	multiple	JJ
cord-290566-tmsocyfc	431	28	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	431	29	.	.	.
cord-290566-tmsocyfc	432	1	Distribution	distribution	NN
cord-290566-tmsocyfc	432	2	of	of	IN
cord-290566-tmsocyfc	432	3	T	t	NN
cord-290566-tmsocyfc	432	4	cells	cell	NNS
cord-290566-tmsocyfc	432	5	,	,	,
cord-290566-tmsocyfc	432	6	T	t	NN
cord-290566-tmsocyfc	432	7	cell	cell	NN
cord-290566-tmsocyfc	432	8	subsets	subset	NNS
cord-290566-tmsocyfc	432	9	and	and	CC
cord-290566-tmsocyfc	432	10	Ia	Ia	NNP
cord-290566-tmsocyfc	432	11	-	-	HYPH
cord-290566-tmsocyfc	432	12	positive	positive	JJ
cord-290566-tmsocyfc	432	13	macrophages	macrophage	NNS
cord-290566-tmsocyfc	432	14	in	in	IN
cord-290566-tmsocyfc	432	15	lesions	lesion	NNS
cord-290566-tmsocyfc	432	16	of	of	IN
cord-290566-tmsocyfc	432	17	diVerent	diVerent	NNP
cord-290566-tmsocyfc	432	18	ages	age	NNS
cord-290566-tmsocyfc	433	1	Multiple	multiple	JJ
cord-290566-tmsocyfc	433	2	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	434	1	:	:	:
cord-290566-tmsocyfc	434	2	Distribution	distribution	NN
cord-290566-tmsocyfc	434	3	of	of	IN
cord-290566-tmsocyfc	434	4	T	T	NNP
cord-290566-tmsocyfc	434	5	cell	cell	NN
cord-290566-tmsocyfc	434	6	subsets	subset	NNS
cord-290566-tmsocyfc	434	7	within	within	IN
cord-290566-tmsocyfc	434	8	active	active	JJ
cord-290566-tmsocyfc	434	9	chronic	chronic	JJ
cord-290566-tmsocyfc	434	10	lesions	lesion	NNS
cord-290566-tmsocyfc	434	11	Skewed	skewed	JJ
cord-290566-tmsocyfc	434	12	T	t	NN
cord-290566-tmsocyfc	434	13	-	-	HYPH
cord-290566-tmsocyfc	434	14	cell	cell	NN
cord-290566-tmsocyfc	434	15	receptor	receptor	NN
cord-290566-tmsocyfc	434	16	repertoire	repertoire	NN
cord-290566-tmsocyfc	434	17	in	in	IN
cord-290566-tmsocyfc	434	18	genetically	genetically	RB
cord-290566-tmsocyfc	434	19	identical	identical	JJ
cord-290566-tmsocyfc	434	20	twins	twin	NNS
cord-290566-tmsocyfc	434	21	correlates	correlate	VBZ
cord-290566-tmsocyfc	434	22	with	with	IN
cord-290566-tmsocyfc	434	23	multiple	multiple	JJ
cord-290566-tmsocyfc	434	24	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	434	25	IL-23	IL-23	NNP
cord-290566-tmsocyfc	434	26	is	be	VBZ
cord-290566-tmsocyfc	434	27	increased	increase	VBN
cord-290566-tmsocyfc	434	28	in	in	IN
cord-290566-tmsocyfc	434	29	dendritic	dendritic	JJ
cord-290566-tmsocyfc	434	30	cells	cell	NNS
cord-290566-tmsocyfc	434	31	in	in	IN
cord-290566-tmsocyfc	434	32	multiple	multiple	JJ
cord-290566-tmsocyfc	434	33	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	434	34	and	and	CC
cord-290566-tmsocyfc	434	35	down	down	JJ
cord-290566-tmsocyfc	434	36	-	-	HYPH
cord-290566-tmsocyfc	434	37	regulation	regulation	NN
cord-290566-tmsocyfc	434	38	of	of	IN
cord-290566-tmsocyfc	434	39	IL-23	IL-23	NNP
cord-290566-tmsocyfc	434	40	by	by	IN
cord-290566-tmsocyfc	434	41	antisense	antisense	NN
cord-290566-tmsocyfc	434	42	oligos	oligo	NNS
cord-290566-tmsocyfc	434	43	increases	increase	VBZ
cord-290566-tmsocyfc	434	44	dendritic	dendritic	JJ
cord-290566-tmsocyfc	434	45	cell	cell	NN
cord-290566-tmsocyfc	434	46	IL-10	IL-10	NNP
cord-290566-tmsocyfc	434	47	production	production	NN
cord-290566-tmsocyfc	434	48	Treatment	treatment	NN
cord-290566-tmsocyfc	434	49	of	of	IN
cord-290566-tmsocyfc	434	50	multiple	multiple	JJ
cord-290566-tmsocyfc	434	51	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	434	52	with	with	IN
cord-290566-tmsocyfc	434	53	the	the	DT
cord-290566-tmsocyfc	434	54	monoclonal	monoclonal	JJ
cord-290566-tmsocyfc	434	55	anti	anti	NNP
cord-290566-tmsocyfc	434	56	-	-	NNP
cord-290566-tmsocyfc	434	57	CD4	cd4	JJ
cord-290566-tmsocyfc	434	58	antibody	antibody	NN
cord-290566-tmsocyfc	434	59	cM	cM	NNP
cord-290566-tmsocyfc	434	60	-	-	HYPH
cord-290566-tmsocyfc	434	61	T412	T412	NNP
cord-290566-tmsocyfc	434	62	:	:	:
cord-290566-tmsocyfc	434	63	Results	result	NNS
cord-290566-tmsocyfc	434	64	of	of	IN
cord-290566-tmsocyfc	434	65	a	a	DT
cord-290566-tmsocyfc	434	66	randomized	randomized	JJ
cord-290566-tmsocyfc	434	67	,	,	,
cord-290566-tmsocyfc	434	68	double	double	JJ
cord-290566-tmsocyfc	434	69	-	-	HYPH
cord-290566-tmsocyfc	434	70	blind	blind	JJ
cord-290566-tmsocyfc	434	71	,	,	,
cord-290566-tmsocyfc	434	72	placebo	placebo	NN
cord-290566-tmsocyfc	434	73	-	-	HYPH
cord-290566-tmsocyfc	434	74	controlled	control	VBN
cord-290566-tmsocyfc	434	75	,	,	,
cord-290566-tmsocyfc	434	76	MR	MR	NNP
cord-290566-tmsocyfc	434	77	-	-	HYPH
cord-290566-tmsocyfc	434	78	monitored	monitor	VBN
cord-290566-tmsocyfc	434	79	phase	phase	NN
cord-290566-tmsocyfc	434	80	II	II	NNP
cord-290566-tmsocyfc	434	81	trial	trial	NN
cord-290566-tmsocyfc	434	82	Progressive	progressive	JJ
cord-290566-tmsocyfc	434	83	multifocal	multifocal	JJ
cord-290566-tmsocyfc	434	84	leukoencephalopathy	leukoencephalopathy	NNP
cord-290566-tmsocyfc	434	85	after	after	IN
cord-290566-tmsocyfc	434	86	natalizumab	natalizumab	NNS
cord-290566-tmsocyfc	434	87	therapy	therapy	NN
cord-290566-tmsocyfc	434	88	for	for	IN
cord-290566-tmsocyfc	434	89	Crohn	Crohn	NNP
cord-290566-tmsocyfc	434	90	's	's	POS
cord-290566-tmsocyfc	434	91	disease	disease	NN
cord-290566-tmsocyfc	434	92	Functional	functional	JJ
cord-290566-tmsocyfc	434	93	properties	property	NNS
cord-290566-tmsocyfc	434	94	of	of	IN
cord-290566-tmsocyfc	434	95	myelin	myelin	NN
cord-290566-tmsocyfc	434	96	oligodendrocyte	oligodendrocyte	NNP
cord-290566-tmsocyfc	434	97	glycoprotein	glycoprotein	NN
cord-290566-tmsocyfc	434	98	-	-	HYPH
cord-290566-tmsocyfc	434	99	reactive	reactive	JJ
cord-290566-tmsocyfc	434	100	T	t	NN
cord-290566-tmsocyfc	434	101	cells	cell	NNS
cord-290566-tmsocyfc	434	102	in	in	IN
cord-290566-tmsocyfc	434	103	multiple	multiple	JJ
cord-290566-tmsocyfc	434	104	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	434	105	patients	patient	NNS
cord-290566-tmsocyfc	434	106	and	and	CC
cord-290566-tmsocyfc	434	107	controls	control	VBZ
cord-290566-tmsocyfc	434	108	T	T	NNP
cord-290566-tmsocyfc	434	109	cell	cell	NN
cord-290566-tmsocyfc	434	110	vaccination	vaccination	NN
cord-290566-tmsocyfc	434	111	in	in	IN
cord-290566-tmsocyfc	434	112	multiple	multiple	JJ
cord-290566-tmsocyfc	434	113	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	434	114	patients	patient	NNS
cord-290566-tmsocyfc	434	115	with	with	IN
cord-290566-tmsocyfc	434	116	autologous	autologous	JJ
cord-290566-tmsocyfc	434	117	CSF	csf	NN
cord-290566-tmsocyfc	434	118	-	-	HYPH
cord-290566-tmsocyfc	434	119	derived	derive	VBN
cord-290566-tmsocyfc	434	120	activated	activate	VBN
cord-290566-tmsocyfc	434	121	T	T	NNP
cord-290566-tmsocyfc	434	122	cells	cell	NNS
cord-290566-tmsocyfc	434	123	:	:	:
cord-290566-tmsocyfc	435	1	Results	result	NNS
cord-290566-tmsocyfc	435	2	from	from	IN
cord-290566-tmsocyfc	435	3	a	a	DT
cord-290566-tmsocyfc	435	4	pilot	pilot	NN
cord-290566-tmsocyfc	435	5	study	study	NN
cord-290566-tmsocyfc	435	6	TCR	TCR	NNP
cord-290566-tmsocyfc	435	7	peptide	peptide	JJ
cord-290566-tmsocyfc	435	8	vaccination	vaccination	NN
cord-290566-tmsocyfc	435	9	in	in	IN
cord-290566-tmsocyfc	435	10	multiple	multiple	JJ
cord-290566-tmsocyfc	435	11	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	435	12	:	:	:
cord-290566-tmsocyfc	435	13	Boosting	boost	VBG
cord-290566-tmsocyfc	435	14	a	a	DT
cord-290566-tmsocyfc	435	15	deficient	deficient	JJ
cord-290566-tmsocyfc	435	16	natural	natural	JJ
cord-290566-tmsocyfc	435	17	regulatory	regulatory	JJ
cord-290566-tmsocyfc	435	18	network	network	NN
cord-290566-tmsocyfc	435	19	that	that	WDT
cord-290566-tmsocyfc	435	20	may	may	MD
cord-290566-tmsocyfc	435	21	involve	involve	VB
cord-290566-tmsocyfc	435	22	TCR	TCR	NNP
cord-290566-tmsocyfc	435	23	-	-	HYPH
cord-290566-tmsocyfc	435	24	specific	specific	JJ
cord-290566-tmsocyfc	435	25	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	435	26	CD25þ	CD25þ	NNP
cord-290566-tmsocyfc	435	27	Treg	Treg	NNP
cord-290566-tmsocyfc	435	28	cells	cell	NNS
cord-290566-tmsocyfc	435	29	Treatment	treatment	NN
cord-290566-tmsocyfc	435	30	of	of	IN
cord-290566-tmsocyfc	435	31	multiple	multiple	JJ
cord-290566-tmsocyfc	435	32	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	435	33	with	with	IN
cord-290566-tmsocyfc	435	34	T	t	NN
cord-290566-tmsocyfc	435	35	-	-	HYPH
cord-290566-tmsocyfc	435	36	cell	cell	NN
cord-290566-tmsocyfc	435	37	receptor	receptor	NN
cord-290566-tmsocyfc	435	38	peptides	peptide	NNS
cord-290566-tmsocyfc	435	39	:	:	:
cord-290566-tmsocyfc	435	40	Results	result	NNS
cord-290566-tmsocyfc	435	41	of	of	IN
cord-290566-tmsocyfc	435	42	a	a	DT
cord-290566-tmsocyfc	435	43	double	double	JJ
cord-290566-tmsocyfc	435	44	-	-	HYPH
cord-290566-tmsocyfc	435	45	blind	blind	JJ
cord-290566-tmsocyfc	435	46	pilot	pilot	NN
cord-290566-tmsocyfc	435	47	trial	trial	NN
cord-290566-tmsocyfc	435	48	The	the	DT
cord-290566-tmsocyfc	435	49	functional	functional	JJ
cord-290566-tmsocyfc	435	50	significance	significance	NN
cord-290566-tmsocyfc	435	51	of	of	IN
cord-290566-tmsocyfc	435	52	epitope	epitope	NN
cord-290566-tmsocyfc	435	53	spreading	spreading	NN
cord-290566-tmsocyfc	435	54	and	and	CC
cord-290566-tmsocyfc	435	55	its	-PRON-	PRP$
cord-290566-tmsocyfc	435	56	regulation	regulation	NN
cord-290566-tmsocyfc	435	57	by	by	IN
cord-290566-tmsocyfc	435	58	co	co	JJ
cord-290566-tmsocyfc	435	59	-	-	JJ
cord-290566-tmsocyfc	435	60	stimulatory	stimulatory	JJ
cord-290566-tmsocyfc	435	61	molecules	molecule	NNS
cord-290566-tmsocyfc	435	62	TGF	TGF	NNP
cord-290566-tmsocyfc	435	63	in	in	IN
cord-290566-tmsocyfc	435	64	the	the	DT
cord-290566-tmsocyfc	435	65	context	context	NN
cord-290566-tmsocyfc	435	66	of	of	IN
cord-290566-tmsocyfc	435	67	an	an	DT
cord-290566-tmsocyfc	435	68	inflammatory	inflammatory	JJ
cord-290566-tmsocyfc	435	69	cytokine	cytokine	NN
cord-290566-tmsocyfc	435	70	milieu	milieu	NN
cord-290566-tmsocyfc	435	71	supports	support	VBZ
cord-290566-tmsocyfc	435	72	de	de	NNP
cord-290566-tmsocyfc	435	73	novo	novo	NNP
cord-290566-tmsocyfc	435	74	diVerentiation	diVerentiation	NNP
cord-290566-tmsocyfc	435	75	of	of	IN
cord-290566-tmsocyfc	435	76	IL-17-producing	IL-17-producing	NNP
cord-290566-tmsocyfc	435	77	T	T	NNP
cord-290566-tmsocyfc	435	78	cells	cell	NNS
cord-290566-tmsocyfc	435	79	Loss	loss	NN
cord-290566-tmsocyfc	435	80	of	of	IN
cord-290566-tmsocyfc	435	81	functional	functional	JJ
cord-290566-tmsocyfc	435	82	suppression	suppression	NN
cord-290566-tmsocyfc	435	83	by	by	IN
cord-290566-tmsocyfc	435	84	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	435	85	CD25þ	CD25þ	NNP
cord-290566-tmsocyfc	435	86	regulatory	regulatory	JJ
cord-290566-tmsocyfc	435	87	T	t	NN
cord-290566-tmsocyfc	435	88	cells	cell	NNS
cord-290566-tmsocyfc	435	89	in	in	IN
cord-290566-tmsocyfc	435	90	patients	patient	NNS
cord-290566-tmsocyfc	435	91	with	with	IN
cord-290566-tmsocyfc	435	92	multiple	multiple	JJ
cord-290566-tmsocyfc	435	93	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	435	94	Expression	expression	NN
cord-290566-tmsocyfc	435	95	of	of	IN
cord-290566-tmsocyfc	435	96	costimulatory	costimulatory	NN
cord-290566-tmsocyfc	435	97	molecules	molecule	NNS
cord-290566-tmsocyfc	435	98	B7	B7	NNP
cord-290566-tmsocyfc	435	99	-	-	HYPH
cord-290566-tmsocyfc	435	100	1	1	CD
cord-290566-tmsocyfc	435	101	(	(	-LRB-
cord-290566-tmsocyfc	435	102	CD80	CD80	NNP
cord-290566-tmsocyfc	435	103	)	)	-RRB-
cord-290566-tmsocyfc	435	104	,	,	,
cord-290566-tmsocyfc	435	105	B7	b7	NN
cord-290566-tmsocyfc	435	106	-	-	HYPH
cord-290566-tmsocyfc	435	107	2	2	CD
cord-290566-tmsocyfc	435	108	(	(	-LRB-
cord-290566-tmsocyfc	435	109	CD86	CD86	NNP
cord-290566-tmsocyfc	435	110	)	)	-RRB-
cord-290566-tmsocyfc	435	111	,	,	,
cord-290566-tmsocyfc	435	112	and	and	CC
cord-290566-tmsocyfc	435	113	interleukin	interleukin	NN
cord-290566-tmsocyfc	435	114	12	12	CD
cord-290566-tmsocyfc	435	115	cytokine	cytokine	NN
cord-290566-tmsocyfc	435	116	in	in	IN
cord-290566-tmsocyfc	435	117	multiple	multiple	JJ
cord-290566-tmsocyfc	435	118	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	435	119	lesions	lesion	NNS
cord-290566-tmsocyfc	435	120	Neuroprotection	Neuroprotection	NNP
cord-290566-tmsocyfc	435	121	by	by	IN
cord-290566-tmsocyfc	435	122	T	T	NNP
cord-290566-tmsocyfc	435	123	-	-	HYPH
cord-290566-tmsocyfc	435	124	cells	cell	NNS
cord-290566-tmsocyfc	435	125	depends	depend	VBZ
cord-290566-tmsocyfc	435	126	on	on	IN
cord-290566-tmsocyfc	435	127	their	-PRON-	PRP$
cord-290566-tmsocyfc	435	128	subtype	subtype	NN
cord-290566-tmsocyfc	435	129	and	and	CC
cord-290566-tmsocyfc	435	130	activation	activation	NN
cord-290566-tmsocyfc	435	131	state	state	NN
cord-290566-tmsocyfc	435	132	Cytokine	Cytokine	NNP
cord-290566-tmsocyfc	435	133	mRNA	mRNA	NNP
cord-290566-tmsocyfc	435	134	expression	expression	NN
cord-290566-tmsocyfc	435	135	in	in	IN
cord-290566-tmsocyfc	435	136	inflammatory	inflammatory	JJ
cord-290566-tmsocyfc	435	137	multiple	multiple	JJ
cord-290566-tmsocyfc	435	138	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	435	139	lesions	lesion	NNS
cord-290566-tmsocyfc	435	140	:	:	:
cord-290566-tmsocyfc	435	141	Detection	detection	NN
cord-290566-tmsocyfc	435	142	by	by	IN
cord-290566-tmsocyfc	435	143	non	non	JJ
cord-290566-tmsocyfc	435	144	-	-	JJ
cord-290566-tmsocyfc	435	145	radioactive	radioactive	JJ
cord-290566-tmsocyfc	435	146	in	in	IN
cord-290566-tmsocyfc	435	147	situ	situ	FW
cord-290566-tmsocyfc	435	148	hybridization	hybridization	NN
cord-290566-tmsocyfc	435	149	T	t	NN
cord-290566-tmsocyfc	435	150	cell	cell	NN
cord-290566-tmsocyfc	435	151	receptor	receptor	NN
cord-290566-tmsocyfc	435	152	V	v	NN
cord-290566-tmsocyfc	435	153	alpha	alpha	NN
cord-290566-tmsocyfc	435	154	-	-	HYPH
cord-290566-tmsocyfc	435	155	V	v	NN
cord-290566-tmsocyfc	435	156	beta	beta	NN
cord-290566-tmsocyfc	435	157	repertoire	repertoire	NN
cord-290566-tmsocyfc	435	158	and	and	CC
cord-290566-tmsocyfc	435	159	cytokine	cytokine	NN
cord-290566-tmsocyfc	435	160	gene	gene	NN
cord-290566-tmsocyfc	435	161	expression	expression	NN
cord-290566-tmsocyfc	435	162	in	in	IN
cord-290566-tmsocyfc	435	163	active	active	JJ
cord-290566-tmsocyfc	435	164	multiple	multiple	JJ
cord-290566-tmsocyfc	435	165	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	435	166	lesions	lesion	NNS
cord-290566-tmsocyfc	435	167	Structure	Structure	NNP
cord-290566-tmsocyfc	435	168	of	of	IN
cord-290566-tmsocyfc	435	169	human	human	JJ
cord-290566-tmsocyfc	435	170	T	t	NN
cord-290566-tmsocyfc	435	171	-	-	HYPH
cord-290566-tmsocyfc	435	172	cell	cell	NN
cord-290566-tmsocyfc	435	173	receptors	receptor	NNS
cord-290566-tmsocyfc	435	174	specific	specific	JJ
cord-290566-tmsocyfc	435	175	for	for	IN
cord-290566-tmsocyfc	435	176	an	an	DT
cord-290566-tmsocyfc	435	177	immunodominant	immunodominant	JJ
cord-290566-tmsocyfc	435	178	myelin	myelin	NN
cord-290566-tmsocyfc	435	179	basic	basic	JJ
cord-290566-tmsocyfc	435	180	protein	protein	NN
cord-290566-tmsocyfc	435	181	peptide	peptide	NN
cord-290566-tmsocyfc	435	182	:	:	:
cord-290566-tmsocyfc	435	183	Positioning	positioning	NN
cord-290566-tmsocyfc	435	184	of	of	IN
cord-290566-tmsocyfc	435	185	T	t	NN
cord-290566-tmsocyfc	435	186	-	-	HYPH
cord-290566-tmsocyfc	435	187	cell	cell	NN
cord-290566-tmsocyfc	435	188	receptors	receptor	NNS
cord-290566-tmsocyfc	435	189	on	on	IN
cord-290566-tmsocyfc	435	190	HLA	HLA	NNP
cord-290566-tmsocyfc	435	191	-	-	HYPH
cord-290566-tmsocyfc	435	192	DR2	DR2	NNP
cord-290566-tmsocyfc	435	193	/	/	SYM
cord-290566-tmsocyfc	435	194	peptide	peptide	NN
cord-290566-tmsocyfc	435	195	complexes	complex	NNS
cord-290566-tmsocyfc	435	196	Recognition	Recognition	NNP
cord-290566-tmsocyfc	435	197	of	of	IN
cord-290566-tmsocyfc	435	198	the	the	DT
cord-290566-tmsocyfc	435	199	immunodominant	immunodominant	JJ
cord-290566-tmsocyfc	435	200	myelin	myelin	NNP
cord-290566-tmsocyfc	435	201	basic	basic	JJ
cord-290566-tmsocyfc	435	202	protein	protein	NN
cord-290566-tmsocyfc	435	203	peptide	peptide	NN
cord-290566-tmsocyfc	435	204	by	by	IN
cord-290566-tmsocyfc	435	205	autoantibodies	autoantibody	NNS
cord-290566-tmsocyfc	435	206	and	and	CC
cord-290566-tmsocyfc	435	207	HLA	HLA	NNP
cord-290566-tmsocyfc	435	208	-	-	HYPH
cord-290566-tmsocyfc	435	209	DR2-restricted	dr2-restricte	VBN
cord-290566-tmsocyfc	435	210	T	T	NNP
cord-290566-tmsocyfc	435	211	cell	cell	NN
cord-290566-tmsocyfc	435	212	clones	clone	NNS
cord-290566-tmsocyfc	435	213	from	from	IN
cord-290566-tmsocyfc	435	214	multiple	multiple	JJ
cord-290566-tmsocyfc	435	215	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	435	216	patients	patient	NNS
cord-290566-tmsocyfc	435	217	.	.	.
cord-290566-tmsocyfc	436	1	Identity	identity	NN
cord-290566-tmsocyfc	436	2	of	of	IN
cord-290566-tmsocyfc	436	3	key	key	JJ
cord-290566-tmsocyfc	436	4	contact	contact	NN
cord-290566-tmsocyfc	436	5	residues	residue	NNS
cord-290566-tmsocyfc	436	6	in	in	IN
cord-290566-tmsocyfc	436	7	the	the	DT
cord-290566-tmsocyfc	436	8	B	b	NN
cord-290566-tmsocyfc	436	9	-	-	HYPH
cord-290566-tmsocyfc	436	10	cell	cell	NN
cord-290566-tmsocyfc	436	11	and	and	CC
cord-290566-tmsocyfc	436	12	T	t	NN
cord-290566-tmsocyfc	436	13	-	-	HYPH
cord-290566-tmsocyfc	436	14	cell	cell	NN
cord-290566-tmsocyfc	436	15	epitopes	epitope	NNS
cord-290566-tmsocyfc	437	1	Crucial	crucial	JJ
cord-290566-tmsocyfc	437	2	role	role	NN
cord-290566-tmsocyfc	437	3	of	of	IN
cord-290566-tmsocyfc	437	4	FOXP3	FOXP3	NNS
cord-290566-tmsocyfc	437	5	in	in	IN
cord-290566-tmsocyfc	437	6	the	the	DT
cord-290566-tmsocyfc	437	7	development	development	NN
cord-290566-tmsocyfc	437	8	and	and	CC
cord-290566-tmsocyfc	437	9	function	function	NN
cord-290566-tmsocyfc	437	10	of	of	IN
cord-290566-tmsocyfc	437	11	human	human	JJ
cord-290566-tmsocyfc	437	12	CD25þ	cd25þ	JJ
cord-290566-tmsocyfc	437	13	CD4þ	CD4þ	NNP
cord-290566-tmsocyfc	437	14	regulatory	regulatory	JJ
cord-290566-tmsocyfc	437	15	T	t	NN
cord-290566-tmsocyfc	437	16	cells	cell	NNS
cord-290566-tmsocyfc	438	1	Human	Human	NNP
cord-290566-tmsocyfc	438	2	IL-17	IL-17	NNP
cord-290566-tmsocyfc	438	3	:	:	:
cord-290566-tmsocyfc	438	4	A	a	DT
cord-290566-tmsocyfc	438	5	novel	novel	JJ
cord-290566-tmsocyfc	438	6	cytokine	cytokine	NN
cord-290566-tmsocyfc	438	7	derived	derive	VBN
cord-290566-tmsocyfc	438	8	from	from	IN
cord-290566-tmsocyfc	438	9	T	T	NNP
cord-290566-tmsocyfc	438	10	cells	cell	NNS
cord-290566-tmsocyfc	438	11	Prevention	Prevention	NNP
cord-290566-tmsocyfc	438	12	of	of	IN
cord-290566-tmsocyfc	438	13	experimental	experimental	JJ
cord-290566-tmsocyfc	438	14	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	438	15	encephalomyelitis	encephalomyelitis	NN
cord-290566-tmsocyfc	438	16	by	by	IN
cord-290566-tmsocyfc	438	17	antibodies	antibody	NNS
cord-290566-tmsocyfc	438	18	against	against	IN
cord-290566-tmsocyfc	438	19	alpha	alpha	NN
cord-290566-tmsocyfc	438	20	4	4	CD
cord-290566-tmsocyfc	438	21	beta	beta	NN
cord-290566-tmsocyfc	438	22	1	1	CD
cord-290566-tmsocyfc	438	23	integrin	integrin	NN
cord-290566-tmsocyfc	438	24	DiVerential	DiVerential	NNP
cord-290566-tmsocyfc	438	25	mechanisms	mechanism	NNS
cord-290566-tmsocyfc	438	26	of	of	IN
cord-290566-tmsocyfc	438	27	action	action	NN
cord-290566-tmsocyfc	438	28	of	of	IN
cord-290566-tmsocyfc	438	29	interferon	interferon	NN
cord-290566-tmsocyfc	438	30	-	-	HYPH
cord-290566-tmsocyfc	438	31	beta	beta	NN
cord-290566-tmsocyfc	438	32	and	and	CC
cord-290566-tmsocyfc	438	33	glatiramer	glatiramer	NNP
cord-290566-tmsocyfc	438	34	aetate	aetate	NN
cord-290566-tmsocyfc	438	35	in	in	IN
cord-290566-tmsocyfc	438	36	MS	MS	NNP
cord-290566-tmsocyfc	439	1	The	the	DT
cord-290566-tmsocyfc	439	2	HMG	HMG	NNP
cord-290566-tmsocyfc	439	3	-	-	HYPH
cord-290566-tmsocyfc	439	4	CoA	coa	NN
cord-290566-tmsocyfc	439	5	reductase	reductase	NN
cord-290566-tmsocyfc	439	6	inhibitor	inhibitor	NN
cord-290566-tmsocyfc	439	7	,	,	,
cord-290566-tmsocyfc	439	8	atorvastatin	atorvastatin	NNP
cord-290566-tmsocyfc	439	9	,	,	,
cord-290566-tmsocyfc	439	10	promotes	promote	VBZ
cord-290566-tmsocyfc	439	11	a	a	DT
cord-290566-tmsocyfc	439	12	Th2	th2	CD
cord-290566-tmsocyfc	439	13	bias	bias	NN
cord-290566-tmsocyfc	439	14	and	and	CC
cord-290566-tmsocyfc	439	15	reverses	reverse	VBZ
cord-290566-tmsocyfc	439	16	paralysis	paralysis	NN
cord-290566-tmsocyfc	439	17	in	in	IN
cord-290566-tmsocyfc	439	18	central	central	JJ
cord-290566-tmsocyfc	439	19	nervous	nervous	JJ
cord-290566-tmsocyfc	439	20	system	system	NN
cord-290566-tmsocyfc	439	21	autoimmune	autoimmune	JJ
cord-290566-tmsocyfc	439	22	disease	disease	NN
cord-290566-tmsocyfc	439	23	T	T	NNP
cord-290566-tmsocyfc	439	24	-	-	HYPH
cord-290566-tmsocyfc	439	25	cell	cell	NN
cord-290566-tmsocyfc	439	26	clones	clone	NNS
cord-290566-tmsocyfc	439	27	specific	specific	JJ
cord-290566-tmsocyfc	439	28	for	for	IN
cord-290566-tmsocyfc	439	29	myelin	myelin	JJ
cord-290566-tmsocyfc	439	30	basic	basic	JJ
cord-290566-tmsocyfc	439	31	protein	protein	NN
cord-290566-tmsocyfc	439	32	induce	induce	VBP
cord-290566-tmsocyfc	439	33	chronic	chronic	JJ
cord-290566-tmsocyfc	439	34	relapsing	relapse	VBG
cord-290566-tmsocyfc	439	35	paralysis	paralysis	NN
cord-290566-tmsocyfc	439	36	and	and	CC
cord-290566-tmsocyfc	439	37	demyelination	demyelination	NN
cord-290566-tmsocyfc	439	38	Autoreactive	Autoreactive	NNP
cord-290566-tmsocyfc	439	39	T	T	NNP
cord-290566-tmsocyfc	439	40	cells	cell	NNS
cord-290566-tmsocyfc	439	41	in	in	IN
cord-290566-tmsocyfc	439	42	multiple	multiple	JJ
cord-290566-tmsocyfc	439	43	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	439	44	Increased	increase	VBN
cord-290566-tmsocyfc	439	45	frequency	frequency	NN
cord-290566-tmsocyfc	439	46	of	of	IN
cord-290566-tmsocyfc	439	47	interleukin	interleukin	NN
cord-290566-tmsocyfc	439	48	2-responsive	2-responsive	CD
cord-290566-tmsocyfc	439	49	T	t	NN
cord-290566-tmsocyfc	439	50	cells	cell	NNS
cord-290566-tmsocyfc	439	51	specific	specific	JJ
cord-290566-tmsocyfc	439	52	for	for	IN
cord-290566-tmsocyfc	439	53	myelin	myelin	JJ
cord-290566-tmsocyfc	439	54	basic	basic	JJ
cord-290566-tmsocyfc	439	55	protein	protein	NN
cord-290566-tmsocyfc	439	56	and	and	CC
cord-290566-tmsocyfc	439	57	proteolipid	proteolipid	NN
cord-290566-tmsocyfc	439	58	protein	protein	NN
cord-290566-tmsocyfc	439	59	in	in	IN
cord-290566-tmsocyfc	439	60	peripheral	peripheral	JJ
cord-290566-tmsocyfc	439	61	blood	blood	NN
cord-290566-tmsocyfc	439	62	and	and	CC
cord-290566-tmsocyfc	439	63	cerebrospinal	cerebrospinal	NN
cord-290566-tmsocyfc	439	64	fluid	fluid	NN
cord-290566-tmsocyfc	439	65	of	of	IN
cord-290566-tmsocyfc	439	66	patients	patient	NNS
cord-290566-tmsocyfc	439	67	with	with	IN
cord-290566-tmsocyfc	439	68	multiple	multiple	JJ
cord-290566-tmsocyfc	439	69	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	439	70	Activation	activation	NN
cord-290566-tmsocyfc	439	71	and	and	CC
cord-290566-tmsocyfc	439	72	clonal	clonal	JJ
cord-290566-tmsocyfc	439	73	expansion	expansion	NN
cord-290566-tmsocyfc	439	74	of	of	IN
cord-290566-tmsocyfc	439	75	human	human	JJ
cord-290566-tmsocyfc	439	76	myelin	myelin	JJ
cord-290566-tmsocyfc	439	77	basic	basic	JJ
cord-290566-tmsocyfc	439	78	protein	protein	NN
cord-290566-tmsocyfc	439	79	-	-	HYPH
cord-290566-tmsocyfc	439	80	reactive	reactive	JJ
cord-290566-tmsocyfc	439	81	T	t	NN
cord-290566-tmsocyfc	439	82	cells	cell	NNS
cord-290566-tmsocyfc	439	83	by	by	IN
cord-290566-tmsocyfc	439	84	bacterial	bacterial	JJ
cord-290566-tmsocyfc	439	85	superantigens	superantigen	NNS
cord-290566-tmsocyfc	439	86	T	T	NNP
cord-290566-tmsocyfc	439	87	cell	cell	NN
cord-290566-tmsocyfc	439	88	vaccination	vaccination	NN
cord-290566-tmsocyfc	439	89	in	in	IN
cord-290566-tmsocyfc	439	90	multiple	multiple	JJ
cord-290566-tmsocyfc	439	91	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	439	92	:	:	:
cord-290566-tmsocyfc	439	93	Results	result	NNS
cord-290566-tmsocyfc	439	94	of	of	IN
cord-290566-tmsocyfc	439	95	a	a	DT
cord-290566-tmsocyfc	439	96	preliminary	preliminary	JJ
cord-290566-tmsocyfc	439	97	study	study	NN
cord-290566-tmsocyfc	439	98	The	the	DT
cord-290566-tmsocyfc	439	99	Tim-3	Tim-3	NNP
cord-290566-tmsocyfc	439	100	ligand	ligand	NN
cord-290566-tmsocyfc	439	101	galectin-9	galectin-9	NN
cord-290566-tmsocyfc	439	102	negatively	negatively	RB
cord-290566-tmsocyfc	439	103	regulates	regulate	VBZ
cord-290566-tmsocyfc	439	104	T	T	NNP
cord-290566-tmsocyfc	439	105	helper	helper	NN
cord-290566-tmsocyfc	439	106	type	type	NN
cord-290566-tmsocyfc	439	107	1	1	CD
cord-290566-tmsocyfc	439	108	immunity	immunity	NN
cord-290566-tmsocyfc	440	1	Glatiramer	glatiramer	JJ
cord-290566-tmsocyfc	440	2	acetate	acetate	NN
cord-290566-tmsocyfc	440	3	-	-	HYPH
cord-290566-tmsocyfc	440	4	specific	specific	JJ
cord-290566-tmsocyfc	440	5	T	t	NN
cord-290566-tmsocyfc	440	6	-	-	HYPH
cord-290566-tmsocyfc	440	7	helper	helper	NN
cord-290566-tmsocyfc	440	8	1-and	1-and	CD
cord-290566-tmsocyfc	440	9	2-type	2-type	CD
cord-290566-tmsocyfc	440	10	cell	cell	NN
cord-290566-tmsocyfc	440	11	lines	line	NNS
cord-290566-tmsocyfc	440	12	produce	produce	VBP
cord-290566-tmsocyfc	440	13	BDNF	BDNF	NNP
cord-290566-tmsocyfc	440	14	:	:	:
cord-290566-tmsocyfc	441	1	Implications	implication	NNS
cord-290566-tmsocyfc	441	2	for	for	IN
cord-290566-tmsocyfc	441	3	multiple	multiple	JJ
cord-290566-tmsocyfc	441	4	sclerosis	sclerosis	NN
cord-290566-tmsocyfc	441	5	therapy	therapy	NN
cord-290566-tmsocyfc	441	6	.	.	.
cord-290566-tmsocyfc	442	1	Brain	brain	NN
cord-290566-tmsocyfc	442	2	-	-	HYPH
cord-290566-tmsocyfc	442	3	derived	derive	VBN
cord-290566-tmsocyfc	442	4	neurotrophic	neurotrophic	NN
cord-290566-tmsocyfc	442	5	factor	factor	NN