id sid tid token lemma pos cord-271176-wdc4p4bc 1 1 key key JJ cord-271176-wdc4p4bc 1 2 : : : cord-271176-wdc4p4bc 1 3 cord-271176-wdc4p4bc cord-271176-wdc4p4bc CD cord-271176-wdc4p4bc 1 4 authors author NNS cord-271176-wdc4p4bc 1 5 : : : cord-271176-wdc4p4bc 1 6 González González NNP cord-271176-wdc4p4bc 1 7 - - HYPH cord-271176-wdc4p4bc 1 8 Scarano Scarano NNP cord-271176-wdc4p4bc 1 9 , , , cord-271176-wdc4p4bc 1 10 Francisco Francisco NNP cord-271176-wdc4p4bc 1 11 ; ; : cord-271176-wdc4p4bc 1 12 Rima Rima NNP cord-271176-wdc4p4bc 1 13 , , , cord-271176-wdc4p4bc 2 1 Bert Bert NNP cord-271176-wdc4p4bc 2 2 title title NN cord-271176-wdc4p4bc 2 3 : : : cord-271176-wdc4p4bc 2 4 Infectious infectious JJ cord-271176-wdc4p4bc 2 5 etiology etiology NN cord-271176-wdc4p4bc 2 6 in in IN cord-271176-wdc4p4bc 2 7 multiple multiple JJ cord-271176-wdc4p4bc 2 8 sclerosis sclerosis NN cord-271176-wdc4p4bc 3 1 : : : cord-271176-wdc4p4bc 3 2 the the DT cord-271176-wdc4p4bc 3 3 debate debate NN cord-271176-wdc4p4bc 3 4 continues continue VBZ cord-271176-wdc4p4bc 3 5 date date NN cord-271176-wdc4p4bc 3 6 : : : cord-271176-wdc4p4bc 3 7 1999 1999 CD cord-271176-wdc4p4bc 3 8 - - SYM cord-271176-wdc4p4bc 3 9 12 12 CD cord-271176-wdc4p4bc 3 10 - - HYPH cord-271176-wdc4p4bc 3 11 01 01 CD cord-271176-wdc4p4bc 3 12 journal journal NN cord-271176-wdc4p4bc 3 13 : : : cord-271176-wdc4p4bc 4 1 Trends trend NNS cord-271176-wdc4p4bc 5 1 Microbiol Microbiol NNP cord-271176-wdc4p4bc 5 2 DOI DOI NNP cord-271176-wdc4p4bc 5 3 : : : cord-271176-wdc4p4bc 6 1 10.1016 10.1016 CD cord-271176-wdc4p4bc 6 2 / / SYM cord-271176-wdc4p4bc 6 3 s0966 s0966 NNP cord-271176-wdc4p4bc 6 4 - - HYPH cord-271176-wdc4p4bc 6 5 842x(99)01634 842x(99)01634 CD cord-271176-wdc4p4bc 6 6 - - HYPH cord-271176-wdc4p4bc 6 7 0 0 CD cord-271176-wdc4p4bc 6 8 sha sha NN cord-271176-wdc4p4bc 6 9 : : : cord-271176-wdc4p4bc 7 1 794e152e662073770daa11812d3890a04797dcdf 794e152e662073770daa11812d3890a04797dcdf CD cord-271176-wdc4p4bc 7 2 doc_id doc_id CD cord-271176-wdc4p4bc 7 3 : : : cord-271176-wdc4p4bc 8 1 271176 271176 CD cord-271176-wdc4p4bc 8 2 cord_uid cord_uid NN cord-271176-wdc4p4bc 8 3 : : : cord-271176-wdc4p4bc 9 1 wdc4p4bc wdc4p4bc CC cord-271176-wdc4p4bc 9 2 ‘ ' `` cord-271176-wdc4p4bc 9 3 Demonstrating demonstrate VBG cord-271176-wdc4p4bc 9 4 Infectious infectious JJ cord-271176-wdc4p4bc 9 5 Cause cause NN cord-271176-wdc4p4bc 9 6 : : : cord-271176-wdc4p4bc 9 7 Viral viral JJ cord-271176-wdc4p4bc 9 8 and and CC cord-271176-wdc4p4bc 9 9 Bacterial bacterial JJ cord-271176-wdc4p4bc 9 10 Infections Infections NNPS cord-271176-wdc4p4bc 9 11 in in IN cord-271176-wdc4p4bc 9 12 MS MS NNP cord-271176-wdc4p4bc 9 13 and and CC cord-271176-wdc4p4bc 9 14 Related Related NNP cord-271176-wdc4p4bc 9 15 Disorders Disorders NNPS cord-271176-wdc4p4bc 9 16 ’ ' '' cord-271176-wdc4p4bc 9 17 was be VBD cord-271176-wdc4p4bc 9 18 held hold VBN cord-271176-wdc4p4bc 9 19 in in IN cord-271176-wdc4p4bc 9 20 Brighton Brighton NNP cord-271176-wdc4p4bc 9 21 , , , cord-271176-wdc4p4bc 9 22 UK UK NNP cord-271176-wdc4p4bc 9 23 , , , cord-271176-wdc4p4bc 9 24 23–25 23–25 JJ cord-271176-wdc4p4bc 9 25 August August NNP cord-271176-wdc4p4bc 9 26 1999 1999 CD cord-271176-wdc4p4bc 9 27 . . . cord-271176-wdc4p4bc 10 1 M M NNP cord-271176-wdc4p4bc 10 2 ultiple ultiple JJ cord-271176-wdc4p4bc 10 3 sclerosis sclerosis NNP cord-271176-wdc4p4bc 10 4 ( ( -LRB- cord-271176-wdc4p4bc 10 5 MS MS NNP cord-271176-wdc4p4bc 10 6 ) ) -RRB- cord-271176-wdc4p4bc 10 7 affects affect VBZ cord-271176-wdc4p4bc 10 8 over over IN cord-271176-wdc4p4bc 10 9 300 300 CD cord-271176-wdc4p4bc 10 10 000 000 CD cord-271176-wdc4p4bc 10 11 Americans Americans NNPS cord-271176-wdc4p4bc 10 12 , , , cord-271176-wdc4p4bc 10 13 85 85 CD cord-271176-wdc4p4bc 10 14 000 000 CD cord-271176-wdc4p4bc 10 15 Britons Britons NNPS cord-271176-wdc4p4bc 10 16 and and CC cord-271176-wdc4p4bc 10 17 perhaps perhaps RB cord-271176-wdc4p4bc 10 18 in in IN cord-271176-wdc4p4bc 10 19 excess excess NN cord-271176-wdc4p4bc 10 20 of of IN cord-271176-wdc4p4bc 10 21 two two CD cord-271176-wdc4p4bc 10 22 million million CD cord-271176-wdc4p4bc 10 23 people people NNS cord-271176-wdc4p4bc 10 24 worldwide worldwide RB cord-271176-wdc4p4bc 10 25 , , , cord-271176-wdc4p4bc 10 26 and and CC cord-271176-wdc4p4bc 10 27 has have VBZ cord-271176-wdc4p4bc 10 28 long long RB cord-271176-wdc4p4bc 10 29 been be VBN cord-271176-wdc4p4bc 10 30 suspected suspect VBN cord-271176-wdc4p4bc 10 31 to to TO cord-271176-wdc4p4bc 10 32 have have VB cord-271176-wdc4p4bc 10 33 an an DT cord-271176-wdc4p4bc 10 34 infectious infectious JJ cord-271176-wdc4p4bc 10 35 etiology etiology NN cord-271176-wdc4p4bc 10 36 . . . cord-271176-wdc4p4bc 11 1 However however RB cord-271176-wdc4p4bc 11 2 , , , cord-271176-wdc4p4bc 11 3 despite despite IN cord-271176-wdc4p4bc 11 4 intensive intensive JJ cord-271176-wdc4p4bc 11 5 investigation investigation NN cord-271176-wdc4p4bc 11 6 , , , cord-271176-wdc4p4bc 11 7 no no DT cord-271176-wdc4p4bc 11 8 single single JJ cord-271176-wdc4p4bc 11 9 infectious infectious JJ cord-271176-wdc4p4bc 11 10 agent agent NN cord-271176-wdc4p4bc 11 11 or or CC cord-271176-wdc4p4bc 11 12 group group NN cord-271176-wdc4p4bc 11 13 of of IN cord-271176-wdc4p4bc 11 14 agents agent NNS cord-271176-wdc4p4bc 11 15 has have VBZ cord-271176-wdc4p4bc 11 16 been be VBN cord-271176-wdc4p4bc 11 17 identified identify VBN cord-271176-wdc4p4bc 11 18 . . . cord-271176-wdc4p4bc 11 19 ' ' '' cord-271176-wdc4p4bc 12 1 Demonstrating demonstrate VBG cord-271176-wdc4p4bc 12 2 Infectious infectious JJ cord-271176-wdc4p4bc 12 3 Cause cause NN cord-271176-wdc4p4bc 12 4 : : : cord-271176-wdc4p4bc 12 5 Viral viral JJ cord-271176-wdc4p4bc 12 6 and and CC cord-271176-wdc4p4bc 12 7 Bacterial bacterial JJ cord-271176-wdc4p4bc 12 8 Infections Infections NNPS cord-271176-wdc4p4bc 12 9 in in IN cord-271176-wdc4p4bc 12 10 MS MS NNP cord-271176-wdc4p4bc 12 11 and and CC cord-271176-wdc4p4bc 12 12 Related Related NNP cord-271176-wdc4p4bc 12 13 Disorders Disorders NNPS cord-271176-wdc4p4bc 12 14 ' ' '' cord-271176-wdc4p4bc 12 15 brought bring VBN cord-271176-wdc4p4bc 12 16 together together RB cord-271176-wdc4p4bc 12 17 immunologists immunologist NNS cord-271176-wdc4p4bc 12 18 , , , cord-271176-wdc4p4bc 12 19 virologists virologist NNS cord-271176-wdc4p4bc 12 20 , , , cord-271176-wdc4p4bc 12 21 epidemiologists epidemiologist NNS cord-271176-wdc4p4bc 12 22 and and CC cord-271176-wdc4p4bc 12 23 clinicians clinician NNS cord-271176-wdc4p4bc 12 24 to to TO cord-271176-wdc4p4bc 12 25 review review VB cord-271176-wdc4p4bc 12 26 the the DT cord-271176-wdc4p4bc 12 27 current current JJ cord-271176-wdc4p4bc 12 28 knowledge knowledge NN cord-271176-wdc4p4bc 12 29 about about IN cord-271176-wdc4p4bc 12 30 the the DT cord-271176-wdc4p4bc 12 31 role role NN cord-271176-wdc4p4bc 12 32 of of IN cord-271176-wdc4p4bc 12 33 infectious infectious JJ cord-271176-wdc4p4bc 12 34 agents agent NNS cord-271176-wdc4p4bc 12 35 in in IN cord-271176-wdc4p4bc 12 36 MS MS NNP cord-271176-wdc4p4bc 12 37 , , , cord-271176-wdc4p4bc 12 38 and and CC cord-271176-wdc4p4bc 12 39 to to TO cord-271176-wdc4p4bc 12 40 identify identify VB cord-271176-wdc4p4bc 12 41 key key JJ cord-271176-wdc4p4bc 12 42 concepts concept NNS cord-271176-wdc4p4bc 12 43 and and CC cord-271176-wdc4p4bc 12 44 questions question NNS cord-271176-wdc4p4bc 12 45 for for IN cord-271176-wdc4p4bc 12 46 research research NN cord-271176-wdc4p4bc 12 47 . . . cord-271176-wdc4p4bc 13 1 Nineteenth nineteenth JJ cord-271176-wdc4p4bc 13 2 - - HYPH cord-271176-wdc4p4bc 13 3 century century NN cord-271176-wdc4p4bc 13 4 descriptions description NNS cord-271176-wdc4p4bc 13 5 of of IN cord-271176-wdc4p4bc 13 6 the the DT cord-271176-wdc4p4bc 13 7 neuropathology neuropathology NN cord-271176-wdc4p4bc 13 8 of of IN cord-271176-wdc4p4bc 13 9 MS MS NNP cord-271176-wdc4p4bc 13 10 emphasized emphasize VBD cord-271176-wdc4p4bc 13 11 the the DT cord-271176-wdc4p4bc 13 12 prominent prominent JJ cord-271176-wdc4p4bc 13 13 infiltration infiltration NN cord-271176-wdc4p4bc 13 14 of of IN cord-271176-wdc4p4bc 13 15 leukocytes leukocyte NNS cord-271176-wdc4p4bc 13 16 and and CC cord-271176-wdc4p4bc 13 17 other other JJ cord-271176-wdc4p4bc 13 18 inflammatory inflammatory JJ cord-271176-wdc4p4bc 13 19 cells cell NNS cord-271176-wdc4p4bc 13 20 into into IN cord-271176-wdc4p4bc 13 21 its -PRON- PRP$ cord-271176-wdc4p4bc 13 22 characteristic characteristic JJ cord-271176-wdc4p4bc 13 23 central central JJ cord-271176-wdc4p4bc 13 24 nervous nervous JJ cord-271176-wdc4p4bc 13 25 system system NN cord-271176-wdc4p4bc 13 26 ( ( -LRB- cord-271176-wdc4p4bc 13 27 CNS CNS NNP cord-271176-wdc4p4bc 13 28 ) ) -RRB- cord-271176-wdc4p4bc 13 29 lesion lesion NN cord-271176-wdc4p4bc 13 30 , , , cord-271176-wdc4p4bc 13 31 which which WDT cord-271176-wdc4p4bc 13 32 is be VBZ cord-271176-wdc4p4bc 13 33 now now RB cord-271176-wdc4p4bc 13 34 called call VBN cord-271176-wdc4p4bc 13 35 a a DT cord-271176-wdc4p4bc 13 36 plaque plaque NN cord-271176-wdc4p4bc 13 37 . . . cord-271176-wdc4p4bc 14 1 Although although IN cord-271176-wdc4p4bc 14 2 it -PRON- PRP cord-271176-wdc4p4bc 14 3 is be VBZ cord-271176-wdc4p4bc 14 4 now now RB cord-271176-wdc4p4bc 14 5 well well RB cord-271176-wdc4p4bc 14 6 accepted accept VBN cord-271176-wdc4p4bc 14 7 that that IN cord-271176-wdc4p4bc 14 8 inflammatory inflammatory JJ cord-271176-wdc4p4bc 14 9 responses response NNS cord-271176-wdc4p4bc 14 10 often often RB cord-271176-wdc4p4bc 14 11 have have VBP cord-271176-wdc4p4bc 14 12 non non JJ cord-271176-wdc4p4bc 14 13 - - JJ cord-271176-wdc4p4bc 14 14 infectious infectious JJ cord-271176-wdc4p4bc 14 15 causes cause NNS cord-271176-wdc4p4bc 14 16 , , , cord-271176-wdc4p4bc 14 17 there there EX cord-271176-wdc4p4bc 14 18 are be VBP cord-271176-wdc4p4bc 14 19 a a DT cord-271176-wdc4p4bc 14 20 number number NN cord-271176-wdc4p4bc 14 21 of of IN cord-271176-wdc4p4bc 14 22 clues clue NNS cord-271176-wdc4p4bc 14 23 that that WDT cord-271176-wdc4p4bc 14 24 point point VBP cord-271176-wdc4p4bc 14 25 towards towards IN cord-271176-wdc4p4bc 14 26 an an DT cord-271176-wdc4p4bc 14 27 exogenous exogenous JJ cord-271176-wdc4p4bc 14 28 , , , cord-271176-wdc4p4bc 14 29 possibly possibly RB cord-271176-wdc4p4bc 14 30 infectious infectious JJ cord-271176-wdc4p4bc 14 31 , , , cord-271176-wdc4p4bc 14 32 factor factor NN cord-271176-wdc4p4bc 14 33 or or CC cord-271176-wdc4p4bc 14 34 factors factor NNS cord-271176-wdc4p4bc 14 35 as as IN cord-271176-wdc4p4bc 14 36 an an DT cord-271176-wdc4p4bc 14 37 important important JJ cord-271176-wdc4p4bc 14 38 component component NN cord-271176-wdc4p4bc 14 39 of of IN cord-271176-wdc4p4bc 14 40 MS MS NNP cord-271176-wdc4p4bc 14 41 . . . cord-271176-wdc4p4bc 15 1 For for IN cord-271176-wdc4p4bc 15 2 example example NN cord-271176-wdc4p4bc 15 3 , , , cord-271176-wdc4p4bc 15 4 studies study NNS cord-271176-wdc4p4bc 15 5 of of IN cord-271176-wdc4p4bc 15 6 twins twin NNS cord-271176-wdc4p4bc 15 7 with with IN cord-271176-wdc4p4bc 15 8 MS MS NNP cord-271176-wdc4p4bc 15 9 indicate indicate VBP cord-271176-wdc4p4bc 15 10 that that IN cord-271176-wdc4p4bc 15 11 monozygosity monozygosity NN cord-271176-wdc4p4bc 15 12 is be VBZ cord-271176-wdc4p4bc 15 13 associated associate VBN cord-271176-wdc4p4bc 15 14 with with IN cord-271176-wdc4p4bc 15 15 a a DT cord-271176-wdc4p4bc 15 16 disease disease NN cord-271176-wdc4p4bc 15 17 concordance concordance NN cord-271176-wdc4p4bc 15 18 of of IN cord-271176-wdc4p4bc 15 19 ~35 ~35 NFP cord-271176-wdc4p4bc 15 20 % % NN cord-271176-wdc4p4bc 15 21 which which WDT cord-271176-wdc4p4bc 15 22 , , , cord-271176-wdc4p4bc 15 23 although although IN cord-271176-wdc4p4bc 15 24 suggesting suggest VBG cord-271176-wdc4p4bc 15 25 a a DT cord-271176-wdc4p4bc 15 26 strong strong JJ cord-271176-wdc4p4bc 15 27 genetic genetic JJ cord-271176-wdc4p4bc 15 28 component component NN cord-271176-wdc4p4bc 15 29 ( ( -LRB- cord-271176-wdc4p4bc 15 30 the the DT cord-271176-wdc4p4bc 15 31 concordance concordance NN cord-271176-wdc4p4bc 15 32 for for IN cord-271176-wdc4p4bc 15 33 dizygotic dizygotic JJ cord-271176-wdc4p4bc 15 34 twins twin NNS cord-271176-wdc4p4bc 15 35 is be VBZ cord-271176-wdc4p4bc 15 36 in in IN cord-271176-wdc4p4bc 15 37 the the DT cord-271176-wdc4p4bc 15 38 order order NN cord-271176-wdc4p4bc 15 39 of of IN cord-271176-wdc4p4bc 15 40 4 4 CD cord-271176-wdc4p4bc 15 41 % % NN cord-271176-wdc4p4bc 15 42 ) ) -RRB- cord-271176-wdc4p4bc 15 43 , , , cord-271176-wdc4p4bc 15 44 also also RB cord-271176-wdc4p4bc 15 45 indicates indicate VBZ cord-271176-wdc4p4bc 15 46 that that IN cord-271176-wdc4p4bc 15 47 the the DT cord-271176-wdc4p4bc 15 48 disease disease NN cord-271176-wdc4p4bc 15 49 is be VBZ cord-271176-wdc4p4bc 15 50 influenced influence VBN cord-271176-wdc4p4bc 15 51 by by IN cord-271176-wdc4p4bc 15 52 additional additional JJ cord-271176-wdc4p4bc 15 53 , , , cord-271176-wdc4p4bc 15 54 possibly possibly RB cord-271176-wdc4p4bc 15 55 environmental environmental JJ cord-271176-wdc4p4bc 15 56 , , , cord-271176-wdc4p4bc 15 57 factors factor NNS cord-271176-wdc4p4bc 15 58 . . . cord-271176-wdc4p4bc 16 1 Furthermore furthermore RB cord-271176-wdc4p4bc 16 2 , , , cord-271176-wdc4p4bc 16 3 there there EX cord-271176-wdc4p4bc 16 4 is be VBZ cord-271176-wdc4p4bc 16 5 a a DT cord-271176-wdc4p4bc 16 6 strong strong JJ cord-271176-wdc4p4bc 16 7 geographical geographical JJ cord-271176-wdc4p4bc 16 8 influence influence NN cord-271176-wdc4p4bc 16 9 on on IN cord-271176-wdc4p4bc 16 10 MS MS NNP cord-271176-wdc4p4bc 16 11 prevalence prevalence NN cord-271176-wdc4p4bc 16 12 : : : cord-271176-wdc4p4bc 16 13 the the DT cord-271176-wdc4p4bc 16 14 rates rate NNS cord-271176-wdc4p4bc 16 15 range range VBP cord-271176-wdc4p4bc 16 16 from from IN cord-271176-wdc4p4bc 16 17 150 150 CD cord-271176-wdc4p4bc 16 18 - - SYM cord-271176-wdc4p4bc 16 19 250 250 CD cord-271176-wdc4p4bc 16 20 per per IN cord-271176-wdc4p4bc 16 21 100 100 CD cord-271176-wdc4p4bc 16 22 000 000 CD cord-271176-wdc4p4bc 16 23 in in IN cord-271176-wdc4p4bc 16 24 northern northern JJ cord-271176-wdc4p4bc 16 25 Europe Europe NNP cord-271176-wdc4p4bc 16 26 and and CC cord-271176-wdc4p4bc 16 27 in in IN cord-271176-wdc4p4bc 16 28 the the DT cord-271176-wdc4p4bc 16 29 northernmost northernmost JJ cord-271176-wdc4p4bc 16 30 USA USA NNP cord-271176-wdc4p4bc 16 31 , , , cord-271176-wdc4p4bc 16 32 whereas whereas IN cord-271176-wdc4p4bc 16 33 in in IN cord-271176-wdc4p4bc 16 34 southern southern JJ cord-271176-wdc4p4bc 16 35 Europe Europe NNP cord-271176-wdc4p4bc 16 36 the the DT cord-271176-wdc4p4bc 16 37 prevalence prevalence NN cord-271176-wdc4p4bc 16 38 drops drop VBZ cord-271176-wdc4p4bc 16 39 to to IN cord-271176-wdc4p4bc 16 40 ~40 ~40 XX cord-271176-wdc4p4bc 16 41 per per IN cord-271176-wdc4p4bc 16 42 100 100 CD cord-271176-wdc4p4bc 16 43 000 000 CD cord-271176-wdc4p4bc 16 44 , , , cord-271176-wdc4p4bc 16 45 similar similar JJ cord-271176-wdc4p4bc 16 46 to to IN cord-271176-wdc4p4bc 16 47 the the DT cord-271176-wdc4p4bc 16 48 rates rate NNS cord-271176-wdc4p4bc 16 49 in in IN cord-271176-wdc4p4bc 16 50 the the DT cord-271176-wdc4p4bc 16 51 southern southern JJ cord-271176-wdc4p4bc 16 52 USA USA NNP cord-271176-wdc4p4bc 16 53 . . . cord-271176-wdc4p4bc 17 1 Remarkably remarkably RB cord-271176-wdc4p4bc 17 2 , , , cord-271176-wdc4p4bc 17 3 a a DT cord-271176-wdc4p4bc 17 4 large large JJ cord-271176-wdc4p4bc 17 5 number number NN cord-271176-wdc4p4bc 17 6 of of IN cord-271176-wdc4p4bc 17 7 epidemiological epidemiological JJ cord-271176-wdc4p4bc 17 8 studies study NNS cord-271176-wdc4p4bc 17 9 have have VBP cord-271176-wdc4p4bc 17 10 shown show VBN cord-271176-wdc4p4bc 17 11 that that IN cord-271176-wdc4p4bc 17 12 individuals individual NNS cord-271176-wdc4p4bc 17 13 maintain maintain VBP cord-271176-wdc4p4bc 17 14 the the DT cord-271176-wdc4p4bc 17 15 ' ' `` cord-271176-wdc4p4bc 17 16 signature signature NN cord-271176-wdc4p4bc 17 17 ' ' '' cord-271176-wdc4p4bc 17 18 incidence incidence NN cord-271176-wdc4p4bc 17 19 associated associate VBN cord-271176-wdc4p4bc 17 20 with with IN cord-271176-wdc4p4bc 17 21 the the DT cord-271176-wdc4p4bc 17 22 geographical geographical JJ cord-271176-wdc4p4bc 17 23 area area NN cord-271176-wdc4p4bc 17 24 in in IN cord-271176-wdc4p4bc 17 25 which which WDT cord-271176-wdc4p4bc 17 26 they -PRON- PRP cord-271176-wdc4p4bc 17 27 spent spend VBD cord-271176-wdc4p4bc 17 28 their -PRON- PRP$ cord-271176-wdc4p4bc 17 29 youth youth NN cord-271176-wdc4p4bc 17 30 , , , cord-271176-wdc4p4bc 17 31 even even RB cord-271176-wdc4p4bc 17 32 after after IN cord-271176-wdc4p4bc 17 33 migrating migrate VBG cord-271176-wdc4p4bc 17 34 from from IN cord-271176-wdc4p4bc 17 35 an an DT cord-271176-wdc4p4bc 17 36 area area NN cord-271176-wdc4p4bc 17 37 of of IN cord-271176-wdc4p4bc 17 38 high high JJ cord-271176-wdc4p4bc 17 39 incidence incidence NN cord-271176-wdc4p4bc 17 40 to to IN cord-271176-wdc4p4bc 17 41 one one CD cord-271176-wdc4p4bc 17 42 of of IN cord-271176-wdc4p4bc 17 43 low low JJ cord-271176-wdc4p4bc 17 44 incidence incidence NN cord-271176-wdc4p4bc 17 45 , , , cord-271176-wdc4p4bc 17 46 or or CC cord-271176-wdc4p4bc 17 47 vice vice NN cord-271176-wdc4p4bc 17 48 versa versa RB cord-271176-wdc4p4bc 17 49 . . . cord-271176-wdc4p4bc 18 1 This this DT cord-271176-wdc4p4bc 18 2 has have VBZ cord-271176-wdc4p4bc 18 3 been be VBN cord-271176-wdc4p4bc 18 4 interpreted interpret VBN cord-271176-wdc4p4bc 18 5 as as IN cord-271176-wdc4p4bc 18 6 evidence evidence NN cord-271176-wdc4p4bc 18 7 that that IN cord-271176-wdc4p4bc 18 8 exposure exposure NN cord-271176-wdc4p4bc 18 9 to to IN cord-271176-wdc4p4bc 18 10 a a DT cord-271176-wdc4p4bc 18 11 microorganism microorganism NN cord-271176-wdc4p4bc 18 12 prior prior RB cord-271176-wdc4p4bc 18 13 to to IN cord-271176-wdc4p4bc 18 14 adulthood adulthood NN cord-271176-wdc4p4bc 18 15 predisposes predispose VBZ cord-271176-wdc4p4bc 18 16 people people NNS cord-271176-wdc4p4bc 18 17 to to IN cord-271176-wdc4p4bc 18 18 the the DT cord-271176-wdc4p4bc 18 19 development development NN cord-271176-wdc4p4bc 18 20 of of IN cord-271176-wdc4p4bc 18 21 MS MS NNP cord-271176-wdc4p4bc 18 22 ( ( -LRB- cord-271176-wdc4p4bc 18 23 Ref Ref NNP cord-271176-wdc4p4bc 18 24 . . . cord-271176-wdc4p4bc 18 25 1 1 CD cord-271176-wdc4p4bc 18 26 ) ) -RRB- cord-271176-wdc4p4bc 18 27 . . . cord-271176-wdc4p4bc 19 1 The the DT cord-271176-wdc4p4bc 19 2 most most RBS cord-271176-wdc4p4bc 19 3 persuasive persuasive JJ cord-271176-wdc4p4bc 19 4 evidence evidence NN cord-271176-wdc4p4bc 19 5 that that IN cord-271176-wdc4p4bc 19 6 foreign foreign JJ cord-271176-wdc4p4bc 19 7 antigens antigen NNS cord-271176-wdc4p4bc 19 8 are be VBP cord-271176-wdc4p4bc 19 9 associated associate VBN cord-271176-wdc4p4bc 19 10 with with IN cord-271176-wdc4p4bc 19 11 MS MS NNP cord-271176-wdc4p4bc 19 12 , , , cord-271176-wdc4p4bc 19 13 however however RB cord-271176-wdc4p4bc 19 14 , , , cord-271176-wdc4p4bc 19 15 is be VBZ cord-271176-wdc4p4bc 19 16 the the DT cord-271176-wdc4p4bc 19 17 indication indication NN cord-271176-wdc4p4bc 19 18 of of IN cord-271176-wdc4p4bc 19 19 a a DT cord-271176-wdc4p4bc 19 20 humoral humoral JJ cord-271176-wdc4p4bc 19 21 immune immune JJ cord-271176-wdc4p4bc 19 22 response response NN cord-271176-wdc4p4bc 19 23 within within IN cord-271176-wdc4p4bc 19 24 the the DT cord-271176-wdc4p4bc 19 25 CNS CNS NNP cord-271176-wdc4p4bc 19 26 . . . cord-271176-wdc4p4bc 20 1 Detectable detectable JJ cord-271176-wdc4p4bc 20 2 as as IN cord-271176-wdc4p4bc 20 3 ' ' `` cord-271176-wdc4p4bc 20 4 oligoclonal oligoclonal JJ cord-271176-wdc4p4bc 20 5 ' ' '' cord-271176-wdc4p4bc 20 6 bands band NNS cord-271176-wdc4p4bc 20 7 in in IN cord-271176-wdc4p4bc 20 8 electrophoresed electrophoresed JJ cord-271176-wdc4p4bc 20 9 samples sample NNS cord-271176-wdc4p4bc 20 10 of of IN cord-271176-wdc4p4bc 20 11 concentrated concentrated JJ cord-271176-wdc4p4bc 20 12 cerebrospinal cerebrospinal NN cord-271176-wdc4p4bc 20 13 fluid fluid NN cord-271176-wdc4p4bc 20 14 ( ( -LRB- cord-271176-wdc4p4bc 20 15 CSF CSF NNP cord-271176-wdc4p4bc 20 16 ) ) -RRB- cord-271176-wdc4p4bc 20 17 proteins protein NNS cord-271176-wdc4p4bc 20 18 , , , cord-271176-wdc4p4bc 20 19 antibodies antibody NNS cord-271176-wdc4p4bc 20 20 produced produce VBN cord-271176-wdc4p4bc 20 21 by by IN cord-271176-wdc4p4bc 20 22 plasma plasma NN cord-271176-wdc4p4bc 20 23 cells cell NNS cord-271176-wdc4p4bc 20 24 within within IN cord-271176-wdc4p4bc 20 25 the the DT cord-271176-wdc4p4bc 20 26 CNS CNS NNP cord-271176-wdc4p4bc 20 27 are be VBP cord-271176-wdc4p4bc 20 28 usually usually RB cord-271176-wdc4p4bc 20 29 seen see VBN cord-271176-wdc4p4bc 20 30 in in IN cord-271176-wdc4p4bc 20 31 infectious infectious JJ cord-271176-wdc4p4bc 20 32 diseases disease NNS cord-271176-wdc4p4bc 20 33 such such JJ cord-271176-wdc4p4bc 20 34 as as IN cord-271176-wdc4p4bc 20 35 syphilis syphili NNS cord-271176-wdc4p4bc 20 36 or or CC cord-271176-wdc4p4bc 20 37 AIDS AIDS NNP cord-271176-wdc4p4bc 20 38 , , , cord-271176-wdc4p4bc 20 39 where where WRB cord-271176-wdc4p4bc 20 40 they -PRON- PRP cord-271176-wdc4p4bc 20 41 are be VBP cord-271176-wdc4p4bc 20 42 directed direct VBN cord-271176-wdc4p4bc 20 43 against against IN cord-271176-wdc4p4bc 20 44 antigenic antigenic JJ cord-271176-wdc4p4bc 20 45 components component NNS cord-271176-wdc4p4bc 20 46 of of IN cord-271176-wdc4p4bc 20 47 the the DT cord-271176-wdc4p4bc 20 48 invading invade VBG cord-271176-wdc4p4bc 20 49 microorganism microorganism NN cord-271176-wdc4p4bc 20 50 . . . cord-271176-wdc4p4bc 21 1 Their -PRON- PRP$ cord-271176-wdc4p4bc 21 2 presence presence NN cord-271176-wdc4p4bc 21 3 and and CC cord-271176-wdc4p4bc 21 4 persistence persistence NN cord-271176-wdc4p4bc 21 5 in in IN cord-271176-wdc4p4bc 21 6 MS MS NNP cord-271176-wdc4p4bc 21 7 ( ( -LRB- cord-271176-wdc4p4bc 21 8 Ref ref NN cord-271176-wdc4p4bc 21 9 . . NNP cord-271176-wdc4p4bc 21 10 2 2 LS cord-271176-wdc4p4bc 21 11 ) ) -RRB- cord-271176-wdc4p4bc 21 12 suggests suggest VBZ cord-271176-wdc4p4bc 21 13 that that IN cord-271176-wdc4p4bc 21 14 a a DT cord-271176-wdc4p4bc 21 15 chronic chronic JJ cord-271176-wdc4p4bc 21 16 infection infection NN cord-271176-wdc4p4bc 21 17 underlies underlie VBZ cord-271176-wdc4p4bc 21 18 the the DT cord-271176-wdc4p4bc 21 19 clinical clinical JJ cord-271176-wdc4p4bc 21 20 syndrome syndrome NN cord-271176-wdc4p4bc 21 21 , , , cord-271176-wdc4p4bc 21 22 although although IN cord-271176-wdc4p4bc 21 23 it -PRON- PRP cord-271176-wdc4p4bc 21 24 is be VBZ cord-271176-wdc4p4bc 21 25 also also RB cord-271176-wdc4p4bc 21 26 possible possible JJ cord-271176-wdc4p4bc 21 27 that that IN cord-271176-wdc4p4bc 21 28 these these DT cord-271176-wdc4p4bc 21 29 antibodies antibody NNS cord-271176-wdc4p4bc 21 30 are be VBP cord-271176-wdc4p4bc 21 31 directed direct VBN cord-271176-wdc4p4bc 21 32 against against IN cord-271176-wdc4p4bc 21 33 as as RB cord-271176-wdc4p4bc 21 34 - - HYPH cord-271176-wdc4p4bc 21 35 yet yet RB cord-271176-wdc4p4bc 21 36 - - HYPH cord-271176-wdc4p4bc 21 37 unidentified unidentified JJ cord-271176-wdc4p4bc 21 38 self self NN cord-271176-wdc4p4bc 21 39 - - HYPH cord-271176-wdc4p4bc 21 40 antigens antigen NNS cord-271176-wdc4p4bc 21 41 . . . cord-271176-wdc4p4bc 22 1 Additionally additionally RB cord-271176-wdc4p4bc 22 2 , , , cord-271176-wdc4p4bc 22 3 analysis analysis NN cord-271176-wdc4p4bc 22 4 of of IN cord-271176-wdc4p4bc 22 5 tissue tissue NN cord-271176-wdc4p4bc 22 6 samples sample NNS cord-271176-wdc4p4bc 22 7 from from IN cord-271176-wdc4p4bc 22 8 around around IN cord-271176-wdc4p4bc 22 9 the the DT cord-271176-wdc4p4bc 22 10 plaques plaque NNS cord-271176-wdc4p4bc 22 11 themselves -PRON- PRP cord-271176-wdc4p4bc 22 12 also also RB cord-271176-wdc4p4bc 22 13 indicates indicate VBZ cord-271176-wdc4p4bc 22 14 antibody antibody NN cord-271176-wdc4p4bc 22 15 production production NN cord-271176-wdc4p4bc 22 16 and and CC cord-271176-wdc4p4bc 22 17 deposition deposition NN cord-271176-wdc4p4bc 22 18 . . . cord-271176-wdc4p4bc 23 1 Most Most JJS cord-271176-wdc4p4bc 23 2 investigators investigator NNS cord-271176-wdc4p4bc 23 3 believe believe VBP cord-271176-wdc4p4bc 23 4 that that IN cord-271176-wdc4p4bc 23 5 identification identification NN cord-271176-wdc4p4bc 23 6 of of IN cord-271176-wdc4p4bc 23 7 the the DT cord-271176-wdc4p4bc 23 8 antigens antigen NNS cord-271176-wdc4p4bc 23 9 against against IN cord-271176-wdc4p4bc 23 10 which which WDT cord-271176-wdc4p4bc 23 11 these these DT cord-271176-wdc4p4bc 23 12 antibodies antibody NNS cord-271176-wdc4p4bc 23 13 are be VBP cord-271176-wdc4p4bc 23 14 directed direct VBN cord-271176-wdc4p4bc 23 15 will will MD cord-271176-wdc4p4bc 23 16 provide provide VB cord-271176-wdc4p4bc 23 17 important important JJ cord-271176-wdc4p4bc 23 18 information information NN cord-271176-wdc4p4bc 23 19 about about IN cord-271176-wdc4p4bc 23 20 MS MS NNP cord-271176-wdc4p4bc 23 21 , , , cord-271176-wdc4p4bc 23 22 perhaps perhaps RB cord-271176-wdc4p4bc 23 23 even even RB cord-271176-wdc4p4bc 23 24 identifying identify VBG cord-271176-wdc4p4bc 23 25 its -PRON- PRP$ cord-271176-wdc4p4bc 23 26 cause cause NN cord-271176-wdc4p4bc 23 27 . . . cord-271176-wdc4p4bc 24 1 Although although IN cord-271176-wdc4p4bc 24 2 there there EX cord-271176-wdc4p4bc 24 3 were be VBD cord-271176-wdc4p4bc 24 4 calls call NNS cord-271176-wdc4p4bc 24 5 from from IN cord-271176-wdc4p4bc 24 6 conference conference NN cord-271176-wdc4p4bc 24 7 ' ' `` cord-271176-wdc4p4bc 24 8 break break NN cord-271176-wdc4p4bc 24 9 - - HYPH cord-271176-wdc4p4bc 24 10 out out NN cord-271176-wdc4p4bc 24 11 ' ' '' cord-271176-wdc4p4bc 24 12 sessions session NNS cord-271176-wdc4p4bc 24 13 for for IN cord-271176-wdc4p4bc 24 14 better well JJR cord-271176-wdc4p4bc 24 15 stratification stratification NN cord-271176-wdc4p4bc 24 16 of of IN cord-271176-wdc4p4bc 24 17 MS MS NNP cord-271176-wdc4p4bc 24 18 patients patient NNS cord-271176-wdc4p4bc 24 19 in in IN cord-271176-wdc4p4bc 24 20 epidemiological epidemiological JJ cord-271176-wdc4p4bc 24 21 studies study NNS cord-271176-wdc4p4bc 24 22 , , , cord-271176-wdc4p4bc 24 23 the the DT cord-271176-wdc4p4bc 24 24 consensus consensus NN cord-271176-wdc4p4bc 24 25 of of IN cord-271176-wdc4p4bc 24 26 studies study NNS cord-271176-wdc4p4bc 24 27 pointing point VBG cord-271176-wdc4p4bc 24 28 in in IN cord-271176-wdc4p4bc 24 29 the the DT cord-271176-wdc4p4bc 24 30 direction direction NN cord-271176-wdc4p4bc 24 31 of of IN cord-271176-wdc4p4bc 24 32 an an DT cord-271176-wdc4p4bc 24 33 environmental environmental JJ cord-271176-wdc4p4bc 24 34 cause cause NN cord-271176-wdc4p4bc 24 35 , , , cord-271176-wdc4p4bc 24 36 as as RB cord-271176-wdc4p4bc 24 37 well well RB cord-271176-wdc4p4bc 24 38 as as IN cord-271176-wdc4p4bc 24 39 the the DT cord-271176-wdc4p4bc 24 40 evidence evidence NN cord-271176-wdc4p4bc 24 41 from from IN cord-271176-wdc4p4bc 24 42 the the DT cord-271176-wdc4p4bc 24 43 oligoclonal oligoclonal JJ cord-271176-wdc4p4bc 24 44 immune immune JJ cord-271176-wdc4p4bc 24 45 responses response NNS cord-271176-wdc4p4bc 24 46 , , , cord-271176-wdc4p4bc 24 47 convinced convince VBD cord-271176-wdc4p4bc 24 48 the the DT cord-271176-wdc4p4bc 24 49 majority majority NN cord-271176-wdc4p4bc 24 50 of of IN cord-271176-wdc4p4bc 24 51 delegates delegate NNS cord-271176-wdc4p4bc 24 52 that that IN cord-271176-wdc4p4bc 24 53 MS MS NNP cord-271176-wdc4p4bc 24 54 is be VBZ cord-271176-wdc4p4bc 24 55 likely likely JJ cord-271176-wdc4p4bc 24 56 to to TO cord-271176-wdc4p4bc 24 57 be be VB cord-271176-wdc4p4bc 24 58 caused cause VBN cord-271176-wdc4p4bc 24 59 or or CC cord-271176-wdc4p4bc 24 60 triggered trigger VBN cord-271176-wdc4p4bc 24 61 by by IN cord-271176-wdc4p4bc 24 62 an an DT cord-271176-wdc4p4bc 24 63 infectious infectious JJ cord-271176-wdc4p4bc 24 64 agent agent NN cord-271176-wdc4p4bc 24 65 . . . cord-271176-wdc4p4bc 25 1 The the DT cord-271176-wdc4p4bc 25 2 infectious infectious JJ cord-271176-wdc4p4bc 25 3 agent agent NN cord-271176-wdc4p4bc 25 4 : : : cord-271176-wdc4p4bc 25 5 known know VBN cord-271176-wdc4p4bc 25 6 or or CC cord-271176-wdc4p4bc 25 7 unknown unknown JJ cord-271176-wdc4p4bc 25 8 ? ? . cord-271176-wdc4p4bc 26 1 The the DT cord-271176-wdc4p4bc 26 2 majority majority NN cord-271176-wdc4p4bc 26 3 of of IN cord-271176-wdc4p4bc 26 4 studies study NNS cord-271176-wdc4p4bc 26 5 concerning concern VBG cord-271176-wdc4p4bc 26 6 specific specific JJ cord-271176-wdc4p4bc 26 7 agents agent NNS cord-271176-wdc4p4bc 26 8 in in IN cord-271176-wdc4p4bc 26 9 MS MS NNP cord-271176-wdc4p4bc 26 10 are be VBP cord-271176-wdc4p4bc 26 11 based base VBN cord-271176-wdc4p4bc 26 12 on on IN cord-271176-wdc4p4bc 26 13 the the DT cord-271176-wdc4p4bc 26 14 assumption assumption NN cord-271176-wdc4p4bc 26 15 that that IN cord-271176-wdc4p4bc 26 16 the the DT cord-271176-wdc4p4bc 26 17 microorganisms microorganism NNS cord-271176-wdc4p4bc 26 18 persist persist VBP cord-271176-wdc4p4bc 26 19 in in IN cord-271176-wdc4p4bc 26 20 the the DT cord-271176-wdc4p4bc 26 21 patient patient NN cord-271176-wdc4p4bc 26 22 , , , cord-271176-wdc4p4bc 26 23 probably probably RB cord-271176-wdc4p4bc 26 24 in in IN cord-271176-wdc4p4bc 26 25 the the DT cord-271176-wdc4p4bc 26 26 CNS CNS NNP cord-271176-wdc4p4bc 27 1 but but CC cord-271176-wdc4p4bc 27 2 perhaps perhaps RB cord-271176-wdc4p4bc 27 3 in in IN cord-271176-wdc4p4bc 27 4 other other JJ cord-271176-wdc4p4bc 27 5 organs organ NNS cord-271176-wdc4p4bc 27 6 . . . cord-271176-wdc4p4bc 28 1 A a DT cord-271176-wdc4p4bc 28 2 number number NN cord-271176-wdc4p4bc 28 3 of of IN cord-271176-wdc4p4bc 28 4 new new JJ cord-271176-wdc4p4bc 28 5 technologies technology NNS cord-271176-wdc4p4bc 28 6 such such JJ cord-271176-wdc4p4bc 28 7 as as IN cord-271176-wdc4p4bc 28 8 representational representational JJ cord-271176-wdc4p4bc 28 9 difference difference NN cord-271176-wdc4p4bc 28 10 analysis analysis NN cord-271176-wdc4p4bc 28 11 ( ( -LRB- cord-271176-wdc4p4bc 28 12 RDA RDA NNP cord-271176-wdc4p4bc 28 13 ) ) -RRB- cord-271176-wdc4p4bc 28 14 , , , cord-271176-wdc4p4bc 28 15 differential differential JJ cord-271176-wdc4p4bc 28 16 display display NN cord-271176-wdc4p4bc 28 17 , , , cord-271176-wdc4p4bc 28 18 consensus consensus NN cord-271176-wdc4p4bc 28 19 PCR PCR NNP cord-271176-wdc4p4bc 28 20 and and CC cord-271176-wdc4p4bc 28 21 phage phage NN cord-271176-wdc4p4bc 28 22 display display NN cord-271176-wdc4p4bc 28 23 are be VBP cord-271176-wdc4p4bc 28 24 now now RB cord-271176-wdc4p4bc 28 25 available available JJ cord-271176-wdc4p4bc 28 26 for for IN cord-271176-wdc4p4bc 28 27 identification identification NN cord-271176-wdc4p4bc 28 28 of of IN cord-271176-wdc4p4bc 28 29 unknown unknown JJ cord-271176-wdc4p4bc 28 30 or or CC cord-271176-wdc4p4bc 28 31 difficult difficult JJ cord-271176-wdc4p4bc 28 32 - - HYPH cord-271176-wdc4p4bc 28 33 to to IN cord-271176-wdc4p4bc 28 34 - - HYPH cord-271176-wdc4p4bc 28 35 culture culture NN cord-271176-wdc4p4bc 28 36 organisms organism NNS cord-271176-wdc4p4bc 28 37 . . . cord-271176-wdc4p4bc 29 1 With with IN cord-271176-wdc4p4bc 29 2 that that DT cord-271176-wdc4p4bc 29 3 in in IN cord-271176-wdc4p4bc 29 4 mind mind NN cord-271176-wdc4p4bc 29 5 , , , cord-271176-wdc4p4bc 29 6 Donald Donald NNP cord-271176-wdc4p4bc 29 7 Gilden Gilden NNP cord-271176-wdc4p4bc 29 8 ( ( -LRB- cord-271176-wdc4p4bc 29 9 University University NNP cord-271176-wdc4p4bc 29 10 of of IN cord-271176-wdc4p4bc 29 11 Colorado Colorado NNP cord-271176-wdc4p4bc 29 12 , , , cord-271176-wdc4p4bc 29 13 Denver Denver NNP cord-271176-wdc4p4bc 29 14 , , , cord-271176-wdc4p4bc 29 15 CO CO NNP cord-271176-wdc4p4bc 29 16 , , , cord-271176-wdc4p4bc 29 17 USA USA NNP cord-271176-wdc4p4bc 29 18 ) ) -RRB- cord-271176-wdc4p4bc 29 19 has have VBZ cord-271176-wdc4p4bc 29 20 adapted adapt VBN cord-271176-wdc4p4bc 29 21 phage phage NN cord-271176-wdc4p4bc 29 22 - - HYPH cord-271176-wdc4p4bc 29 23 display display NN cord-271176-wdc4p4bc 29 24 technology technology NN cord-271176-wdc4p4bc 29 25 to to TO cord-271176-wdc4p4bc 29 26 analyse analyse VB cord-271176-wdc4p4bc 29 27 the the DT cord-271176-wdc4p4bc 29 28 antigen antigen NN cord-271176-wdc4p4bc 29 29 specificity specificity NN cord-271176-wdc4p4bc 29 30 of of IN cord-271176-wdc4p4bc 29 31 oligoclonal oligoclonal JJ cord-271176-wdc4p4bc 29 32 bands band NNS cord-271176-wdc4p4bc 29 33 by by IN cord-271176-wdc4p4bc 29 34 extracting extract VBG cord-271176-wdc4p4bc 29 35 the the DT cord-271176-wdc4p4bc 29 36 RNA RNA NNP cord-271176-wdc4p4bc 29 37 surrounding surround VBG cord-271176-wdc4p4bc 29 38 an an DT cord-271176-wdc4p4bc 29 39 MS MS NNP cord-271176-wdc4p4bc 29 40 plaque plaque NN cord-271176-wdc4p4bc 29 41 and and CC cord-271176-wdc4p4bc 29 42 amplifying amplify VBG cord-271176-wdc4p4bc 29 43 the the DT cord-271176-wdc4p4bc 29 44 immunoglobulin immunoglobulin NN cord-271176-wdc4p4bc 29 45 heavy heavy JJ cord-271176-wdc4p4bc 29 46 and and CC cord-271176-wdc4p4bc 29 47 light light JJ cord-271176-wdc4p4bc 29 48 chains chain NNS cord-271176-wdc4p4bc 29 49 using use VBG cord-271176-wdc4p4bc 29 50 consensus consensus NN cord-271176-wdc4p4bc 29 51 primers primer NNS cord-271176-wdc4p4bc 29 52 . . . cord-271176-wdc4p4bc 30 1 After after IN cord-271176-wdc4p4bc 30 2 cloning clone VBG cord-271176-wdc4p4bc 30 3 into into IN cord-271176-wdc4p4bc 30 4 an an DT cord-271176-wdc4p4bc 30 5 expression expression NN cord-271176-wdc4p4bc 30 6 vector vector NN cord-271176-wdc4p4bc 30 7 , , , cord-271176-wdc4p4bc 30 8 the the DT cord-271176-wdc4p4bc 30 9 immunoglobulins immunoglobulin NNS cord-271176-wdc4p4bc 30 10 are be VBP cord-271176-wdc4p4bc 30 11 displayed display VBN cord-271176-wdc4p4bc 30 12 on on IN cord-271176-wdc4p4bc 30 13 the the DT cord-271176-wdc4p4bc 30 14 coat coat NN cord-271176-wdc4p4bc 30 15 of of IN cord-271176-wdc4p4bc 30 16 a a DT cord-271176-wdc4p4bc 30 17 bacteriophage bacteriophage NN cord-271176-wdc4p4bc 30 18 . . . cord-271176-wdc4p4bc 31 1 These these DT cord-271176-wdc4p4bc 31 2 immunoglobulins immunoglobulin NNS cord-271176-wdc4p4bc 31 3 can can MD cord-271176-wdc4p4bc 31 4 then then RB cord-271176-wdc4p4bc 31 5 be be VB cord-271176-wdc4p4bc 31 6 specifically specifically RB cord-271176-wdc4p4bc 31 7 amplified amplify VBN cord-271176-wdc4p4bc 31 8 , , , cord-271176-wdc4p4bc 31 9 and and CC cord-271176-wdc4p4bc 31 10 the the DT cord-271176-wdc4p4bc 31 11 antigen antigen NN cord-271176-wdc4p4bc 31 12 against against IN cord-271176-wdc4p4bc 31 13 which which WDT cord-271176-wdc4p4bc 31 14 they -PRON- PRP cord-271176-wdc4p4bc 31 15 are be VBP cord-271176-wdc4p4bc 31 16 directed direct VBN cord-271176-wdc4p4bc 31 17 can can MD cord-271176-wdc4p4bc 31 18 subsequently subsequently RB cord-271176-wdc4p4bc 31 19 be be VB cord-271176-wdc4p4bc 31 20 identified identify VBN cord-271176-wdc4p4bc 31 21 . . . cord-271176-wdc4p4bc 32 1 Gilden Gilden NNP cord-271176-wdc4p4bc 32 2 has have VBZ cord-271176-wdc4p4bc 32 3 already already RB cord-271176-wdc4p4bc 32 4 achieved achieve VBN cord-271176-wdc4p4bc 32 5 success success NN cord-271176-wdc4p4bc 32 6 using use VBG cord-271176-wdc4p4bc 32 7 this this DT cord-271176-wdc4p4bc 32 8 approach approach NN cord-271176-wdc4p4bc 32 9 for for IN cord-271176-wdc4p4bc 32 10 at at RB cord-271176-wdc4p4bc 32 11 least least RBS cord-271176-wdc4p4bc 32 12 one one CD cord-271176-wdc4p4bc 32 13 chronic chronic JJ cord-271176-wdc4p4bc 32 14 infection infection NN cord-271176-wdc4p4bc 32 15 caused cause VBN cord-271176-wdc4p4bc 32 16 by by IN cord-271176-wdc4p4bc 32 17 measles measle NNS cord-271176-wdc4p4bc 32 18 virus virus NN cord-271176-wdc4p4bc 32 19 ( ( -LRB- cord-271176-wdc4p4bc 32 20 subacute subacute JJ cord-271176-wdc4p4bc 32 21 sclerosing sclerosing NN cord-271176-wdc4p4bc 32 22 panencephalitis panencephalitis NN cord-271176-wdc4p4bc 32 23 ; ; : cord-271176-wdc4p4bc 32 24 SSPE SSPE NNP cord-271176-wdc4p4bc 32 25 ) ) -RRB- cord-271176-wdc4p4bc 32 26 . . . cord-271176-wdc4p4bc 33 1 His -PRON- PRP$ cord-271176-wdc4p4bc 33 2 laboratory laboratory NN cord-271176-wdc4p4bc 33 3 is be VBZ cord-271176-wdc4p4bc 33 4 now now RB cord-271176-wdc4p4bc 33 5 directing direct VBG cord-271176-wdc4p4bc 33 6 its -PRON- PRP$ cord-271176-wdc4p4bc 33 7 attention attention NN cord-271176-wdc4p4bc 33 8 to to IN cord-271176-wdc4p4bc 33 9 the the DT cord-271176-wdc4p4bc 33 10 MS MS NNP cord-271176-wdc4p4bc 33 11 lesions lesion NNS cord-271176-wdc4p4bc 33 12 and and CC cord-271176-wdc4p4bc 33 13 the the DT cord-271176-wdc4p4bc 33 14 CNS CNS NNP cord-271176-wdc4p4bc 33 15 areas area NNS cord-271176-wdc4p4bc 33 16 where where WRB cord-271176-wdc4p4bc 33 17 the the DT cord-271176-wdc4p4bc 33 18 CSF CSF NNP cord-271176-wdc4p4bc 33 19 is be VBZ cord-271176-wdc4p4bc 33 20 produced produce VBN cord-271176-wdc4p4bc 33 21 . . . cord-271176-wdc4p4bc 34 1 Other other JJ cord-271176-wdc4p4bc 34 2 presentations presentation NNS cord-271176-wdc4p4bc 34 3 concerning concern VBG cord-271176-wdc4p4bc 34 4 molecular molecular JJ cord-271176-wdc4p4bc 34 5 technologies technology NNS cord-271176-wdc4p4bc 34 6 gave give VBD cord-271176-wdc4p4bc 34 7 the the DT cord-271176-wdc4p4bc 34 8 overall overall JJ cord-271176-wdc4p4bc 34 9 impression impression NN cord-271176-wdc4p4bc 34 10 that that IN cord-271176-wdc4p4bc 34 11 the the DT cord-271176-wdc4p4bc 34 12 new new JJ cord-271176-wdc4p4bc 34 13 technologies technology NNS cord-271176-wdc4p4bc 34 14 have have VBP cord-271176-wdc4p4bc 34 15 not not RB cord-271176-wdc4p4bc 34 16 yet yet RB cord-271176-wdc4p4bc 34 17 been be VBN cord-271176-wdc4p4bc 34 18 applied apply VBN cord-271176-wdc4p4bc 34 19 in in IN cord-271176-wdc4p4bc 34 20 a a DT cord-271176-wdc4p4bc 34 21 systematic systematic JJ cord-271176-wdc4p4bc 34 22 fashion fashion NN cord-271176-wdc4p4bc 34 23 to to TO cord-271176-wdc4p4bc 34 24 pathologically pathologically RB cord-271176-wdc4p4bc 34 25 well well RB cord-271176-wdc4p4bc 34 26 defined define VBN cord-271176-wdc4p4bc 34 27 MS MS NNP cord-271176-wdc4p4bc 34 28 tissue tissue NN cord-271176-wdc4p4bc 34 29 , , , cord-271176-wdc4p4bc 34 30 and and CC cord-271176-wdc4p4bc 34 31 that that IN cord-271176-wdc4p4bc 34 32 there there EX cord-271176-wdc4p4bc 34 33 was be VBD cord-271176-wdc4p4bc 34 34 room room NN cord-271176-wdc4p4bc 34 35 for for IN cord-271176-wdc4p4bc 34 36 more more JJR cord-271176-wdc4p4bc 34 37 work work NN cord-271176-wdc4p4bc 34 38 using use VBG cord-271176-wdc4p4bc 34 39 these these DT cord-271176-wdc4p4bc 34 40 approaches approach NNS cord-271176-wdc4p4bc 34 41 . . . cord-271176-wdc4p4bc 35 1 Some some DT cord-271176-wdc4p4bc 35 2 investigators investigator NNS cord-271176-wdc4p4bc 35 3 felt feel VBD cord-271176-wdc4p4bc 35 4 that that IN cord-271176-wdc4p4bc 35 5 the the DT cord-271176-wdc4p4bc 35 6 agent agent NN cord-271176-wdc4p4bc 35 7 that that WDT cord-271176-wdc4p4bc 35 8 induces induce VBZ cord-271176-wdc4p4bc 35 9 MS MS NNP cord-271176-wdc4p4bc 35 10 has have VBZ cord-271176-wdc4p4bc 35 11 already already RB cord-271176-wdc4p4bc 35 12 been be VBN cord-271176-wdc4p4bc 35 13 identified identify VBN cord-271176-wdc4p4bc 35 14 . . . cord-271176-wdc4p4bc 36 1 Subramamiam Subramamiam NNP cord-271176-wdc4p4bc 36 2 Sriram Sriram NNP cord-271176-wdc4p4bc 37 1 ( ( -LRB- cord-271176-wdc4p4bc 37 2 Vanderbilt Vanderbilt NNP cord-271176-wdc4p4bc 37 3 Stallworth Stallworth NNP cord-271176-wdc4p4bc 37 4 Rehabilitation Rehabilitation NNP cord-271176-wdc4p4bc 37 5 Hospital Hospital NNP cord-271176-wdc4p4bc 37 6 , , , cord-271176-wdc4p4bc 37 7 Memphis Memphis NNP cord-271176-wdc4p4bc 37 8 , , , cord-271176-wdc4p4bc 37 9 TN TN NNP cord-271176-wdc4p4bc 37 10 , , , cord-271176-wdc4p4bc 37 11 USA USA NNP cord-271176-wdc4p4bc 37 12 ) ) -RRB- cord-271176-wdc4p4bc 37 13 presented present VBD cord-271176-wdc4p4bc 37 14 data datum NNS cord-271176-wdc4p4bc 37 15 indicating indicate VBG cord-271176-wdc4p4bc 37 16 that that IN cord-271176-wdc4p4bc 37 17 the the DT cord-271176-wdc4p4bc 37 18 CSF CSF NNP cord-271176-wdc4p4bc 37 19 of of IN cord-271176-wdc4p4bc 37 20 97 97 CD cord-271176-wdc4p4bc 37 21 % % NN cord-271176-wdc4p4bc 37 22 of of IN cord-271176-wdc4p4bc 37 23 MS MS NNP cord-271176-wdc4p4bc 37 24 patients patient NNS cord-271176-wdc4p4bc 37 25 ( ( -LRB- cord-271176-wdc4p4bc 37 26 compared compare VBN cord-271176-wdc4p4bc 37 27 with with IN cord-271176-wdc4p4bc 37 28 18 18 CD cord-271176-wdc4p4bc 37 29 % % NN cord-271176-wdc4p4bc 37 30 of of IN cord-271176-wdc4p4bc 37 31 patients patient NNS cord-271176-wdc4p4bc 37 32 with with IN cord-271176-wdc4p4bc 37 33 other other JJ cord-271176-wdc4p4bc 37 34 neurological neurological JJ cord-271176-wdc4p4bc 37 35 diseases disease NNS cord-271176-wdc4p4bc 37 36 ) ) -RRB- cord-271176-wdc4p4bc 37 37 contains contain VBZ cord-271176-wdc4p4bc 37 38 genomic genomic JJ cord-271176-wdc4p4bc 37 39 material material NN cord-271176-wdc4p4bc 37 40 from from IN cord-271176-wdc4p4bc 37 41 the the DT cord-271176-wdc4p4bc 37 42 bacterium bacterium NN cord-271176-wdc4p4bc 37 43 Chlamydia Chlamydia NNP cord-271176-wdc4p4bc 37 44 pneumoniae pneumoniae NN cord-271176-wdc4p4bc 37 45 , , , cord-271176-wdc4p4bc 37 46 as as IN cord-271176-wdc4p4bc 37 47 shown show VBN cord-271176-wdc4p4bc 37 48 by by IN cord-271176-wdc4p4bc 37 49 PCR PCR NNP cord-271176-wdc4p4bc 37 50 amplification amplification NN cord-271176-wdc4p4bc 37 51 . . . cord-271176-wdc4p4bc 38 1 Sriram Sriram NNP cord-271176-wdc4p4bc 38 2 was be VBD cord-271176-wdc4p4bc 38 3 also also RB cord-271176-wdc4p4bc 38 4 able able JJ cord-271176-wdc4p4bc 38 5 to to TO cord-271176-wdc4p4bc 38 6 culture culture VB cord-271176-wdc4p4bc 38 7 C. C. NNP cord-271176-wdc4p4bc 38 8 pneumoniae pneumoniae NN cord-271176-wdc4p4bc 38 9 from from IN cord-271176-wdc4p4bc 38 10 the the DT cord-271176-wdc4p4bc 38 11 CSF CSF NNP cord-271176-wdc4p4bc 38 12 of of IN cord-271176-wdc4p4bc 38 13 MS MS NNP cord-271176-wdc4p4bc 38 14 patients patient NNS cord-271176-wdc4p4bc 38 15 . . . cord-271176-wdc4p4bc 39 1 Furthermore furthermore RB cord-271176-wdc4p4bc 39 2 , , , cord-271176-wdc4p4bc 39 3 oligoclonal oligoclonal JJ cord-271176-wdc4p4bc 39 4 bands band NNS cord-271176-wdc4p4bc 39 5 from from IN cord-271176-wdc4p4bc 39 6 MS MS NNP cord-271176-wdc4p4bc 39 7 CSF CSF NNP cord-271176-wdc4p4bc 39 8 were be VBD cord-271176-wdc4p4bc 39 9 adsorbed adsorb VBN cord-271176-wdc4p4bc 39 10 by by IN cord-271176-wdc4p4bc 39 11 incubation incubation NN cord-271176-wdc4p4bc 39 12 of of IN cord-271176-wdc4p4bc 39 13 the the DT cord-271176-wdc4p4bc 39 14 fluid fluid NN cord-271176-wdc4p4bc 39 15 with with IN cord-271176-wdc4p4bc 39 16 a a DT cord-271176-wdc4p4bc 39 17 C. C. NNP cord-271176-wdc4p4bc 39 18 pneumoniae pneumoniae NN cord-271176-wdc4p4bc 39 19 antigen antigen NN cord-271176-wdc4p4bc 39 20 , , , cord-271176-wdc4p4bc 39 21 but but CC cord-271176-wdc4p4bc 39 22 not not RB cord-271176-wdc4p4bc 39 23 with with IN cord-271176-wdc4p4bc 39 24 antigens antigen NNS cord-271176-wdc4p4bc 39 25 from from IN cord-271176-wdc4p4bc 39 26 herpes herpes NN cord-271176-wdc4p4bc 39 27 simplex simplex NNP cord-271176-wdc4p4bc 39 28 or or CC cord-271176-wdc4p4bc 39 29 measles measles NN cord-271176-wdc4p4bc 39 30 viruses virus NNS cord-271176-wdc4p4bc 39 31 . . . cord-271176-wdc4p4bc 40 1 These these DT cord-271176-wdc4p4bc 40 2 data datum NNS cord-271176-wdc4p4bc 40 3 support support VBP cord-271176-wdc4p4bc 40 4 his -PRON- PRP$ cord-271176-wdc4p4bc 40 5 view view NN cord-271176-wdc4p4bc 40 6 that that IN cord-271176-wdc4p4bc 40 7 the the DT cord-271176-wdc4p4bc 40 8 immune immune JJ cord-271176-wdc4p4bc 40 9 response response NN cord-271176-wdc4p4bc 40 10 in in IN cord-271176-wdc4p4bc 40 11 those those DT cord-271176-wdc4p4bc 40 12 patients patient NNS cord-271176-wdc4p4bc 40 13 was be VBD cord-271176-wdc4p4bc 40 14 directed direct VBN cord-271176-wdc4p4bc 40 15 against against IN cord-271176-wdc4p4bc 40 16 C. C. NNP cord-271176-wdc4p4bc 40 17 pneumoniae pneumoniae NNS cord-271176-wdc4p4bc 40 18 . . . cord-271176-wdc4p4bc 41 1 Sriram Sriram NNP cord-271176-wdc4p4bc 41 2 also also RB cord-271176-wdc4p4bc 41 3 suggested suggest VBD cord-271176-wdc4p4bc 41 4 that that IN cord-271176-wdc4p4bc 41 5 a a DT cord-271176-wdc4p4bc 41 6 therapeutic therapeutic JJ cord-271176-wdc4p4bc 41 7 trial trial NN cord-271176-wdc4p4bc 41 8 with with IN cord-271176-wdc4p4bc 41 9 antibiotics antibiotic NNS cord-271176-wdc4p4bc 41 10 directed direct VBN cord-271176-wdc4p4bc 41 11 against against IN cord-271176-wdc4p4bc 41 12 C. C. NNP cord-271176-wdc4p4bc 41 13 pneumoniae pneumoniae NN cord-271176-wdc4p4bc 41 14 might may MD cord-271176-wdc4p4bc 41 15 be be VB cord-271176-wdc4p4bc 41 16 required require VBN cord-271176-wdc4p4bc 41 17 to to TO cord-271176-wdc4p4bc 41 18 demonstrate demonstrate VB cord-271176-wdc4p4bc 41 19 a a DT cord-271176-wdc4p4bc 41 20 causal causal JJ cord-271176-wdc4p4bc 41 21 association association NN cord-271176-wdc4p4bc 41 22 between between IN cord-271176-wdc4p4bc 41 23 this this DT cord-271176-wdc4p4bc 41 24 microorganism microorganism NN cord-271176-wdc4p4bc 41 25 and and CC cord-271176-wdc4p4bc 41 26 MS MS NNP cord-271176-wdc4p4bc 41 27 . . . cord-271176-wdc4p4bc 42 1 Konstance Konstance NNP cord-271176-wdc4p4bc 42 2 Knox Knox NNP cord-271176-wdc4p4bc 42 3 ( ( -LRB- cord-271176-wdc4p4bc 42 4 Institute Institute NNP cord-271176-wdc4p4bc 42 5 for for IN cord-271176-wdc4p4bc 42 6 Viral Viral NNP cord-271176-wdc4p4bc 42 7 Pathogenesis Pathogenesis NNP cord-271176-wdc4p4bc 42 8 , , , cord-271176-wdc4p4bc 42 9 Milwaukee Milwaukee NNP cord-271176-wdc4p4bc 42 10 , , , cord-271176-wdc4p4bc 42 11 WI WI NNP cord-271176-wdc4p4bc 42 12 , , , cord-271176-wdc4p4bc 42 13 USA USA NNP cord-271176-wdc4p4bc 42 14 ) ) -RRB- cord-271176-wdc4p4bc 42 15 presented present VBD cord-271176-wdc4p4bc 42 16 equally equally RB cord-271176-wdc4p4bc 42 17 compelling compelling JJ cord-271176-wdc4p4bc 42 18 data datum NNS cord-271176-wdc4p4bc 42 19 supporting support VBG cord-271176-wdc4p4bc 42 20 earlier early JJR cord-271176-wdc4p4bc 42 21 suggestions suggestion NNS cord-271176-wdc4p4bc 42 22 3 3 CD cord-271176-wdc4p4bc 42 23 that that IN cord-271176-wdc4p4bc 42 24 human human JJ cord-271176-wdc4p4bc 42 25 herpesvirus herpesvirus NN cord-271176-wdc4p4bc 42 26 six six CD cord-271176-wdc4p4bc 42 27 ( ( -LRB- cord-271176-wdc4p4bc 42 28 HHV-6 HHV-6 NNP cord-271176-wdc4p4bc 42 29 ) ) -RRB- cord-271176-wdc4p4bc 42 30 is be VBZ cord-271176-wdc4p4bc 42 31 associated associate VBN cord-271176-wdc4p4bc 42 32 with with IN cord-271176-wdc4p4bc 42 33 MS MS NNP cord-271176-wdc4p4bc 42 34 . . . cord-271176-wdc4p4bc 43 1 Immunohistochemical immunohistochemical JJ cord-271176-wdc4p4bc 43 2 analysis analysis NN cord-271176-wdc4p4bc 43 3 of of IN cord-271176-wdc4p4bc 43 4 MS MS NNP cord-271176-wdc4p4bc 43 5 plaques plaque NNS cord-271176-wdc4p4bc 43 6 has have VBZ cord-271176-wdc4p4bc 43 7 revealed reveal VBN cord-271176-wdc4p4bc 43 8 a a DT cord-271176-wdc4p4bc 43 9 concentration concentration NN cord-271176-wdc4p4bc 43 10 of of IN cord-271176-wdc4p4bc 43 11 an an DT cord-271176-wdc4p4bc 43 12 HHV-6 HHV-6 NNP cord-271176-wdc4p4bc 43 13 antigen antigen NN cord-271176-wdc4p4bc 43 14 in in IN cord-271176-wdc4p4bc 43 15 oligodendrocytes oligodendrocyte NNS cord-271176-wdc4p4bc 43 16 , , , cord-271176-wdc4p4bc 43 17 the the DT cord-271176-wdc4p4bc 43 18 CNS CNS NNP cord-271176-wdc4p4bc 43 19 cells cell NNS cord-271176-wdc4p4bc 43 20 responsible responsible JJ cord-271176-wdc4p4bc 43 21 for for IN cord-271176-wdc4p4bc 43 22 the the DT cord-271176-wdc4p4bc 43 23 formation formation NN cord-271176-wdc4p4bc 43 24 and and CC cord-271176-wdc4p4bc 43 25 maintenance maintenance NN cord-271176-wdc4p4bc 43 26 of of IN cord-271176-wdc4p4bc 43 27 myelin myelin NN cord-271176-wdc4p4bc 43 28 ( ( -LRB- cord-271176-wdc4p4bc 43 29 myelin myelin JJ cord-271176-wdc4p4bc 43 30 destruction destruction NN cord-271176-wdc4p4bc 43 31 is be VBZ cord-271176-wdc4p4bc 43 32 a a DT cord-271176-wdc4p4bc 43 33 key key JJ cord-271176-wdc4p4bc 43 34 component component NN cord-271176-wdc4p4bc 43 35 of of IN cord-271176-wdc4p4bc 43 36 the the DT cord-271176-wdc4p4bc 43 37 MS MS NNP cord-271176-wdc4p4bc 43 38 lesion lesion NN cord-271176-wdc4p4bc 43 39 ) ) -RRB- cord-271176-wdc4p4bc 43 40 . . . cord-271176-wdc4p4bc 44 1 Knox Knox NNP cord-271176-wdc4p4bc 44 2 and and CC cord-271176-wdc4p4bc 44 3 collaborators collaborator NNS cord-271176-wdc4p4bc 44 4 found find VBD cord-271176-wdc4p4bc 44 5 HHV-6 HHV-6 NNP cord-271176-wdc4p4bc 44 6 expression expression NN cord-271176-wdc4p4bc 44 7 in in IN cord-271176-wdc4p4bc 44 8 17 17 CD cord-271176-wdc4p4bc 44 9 out out IN cord-271176-wdc4p4bc 44 10 of of IN cord-271176-wdc4p4bc 44 11 19 19 CD cord-271176-wdc4p4bc 44 12 patients patient NNS cord-271176-wdc4p4bc 44 13 with with IN cord-271176-wdc4p4bc 44 14 ' ' `` cord-271176-wdc4p4bc 44 15 active active JJ cord-271176-wdc4p4bc 44 16 ' ' '' cord-271176-wdc4p4bc 44 17 disease disease NN cord-271176-wdc4p4bc 44 18 , , , cord-271176-wdc4p4bc 44 19 compared compare VBN cord-271176-wdc4p4bc 44 20 with with IN cord-271176-wdc4p4bc 44 21 only only RB cord-271176-wdc4p4bc 44 22 three three CD cord-271176-wdc4p4bc 44 23 out out IN cord-271176-wdc4p4bc 44 24 of of IN cord-271176-wdc4p4bc 44 25 23 23 CD cord-271176-wdc4p4bc 44 26 patients patient NNS cord-271176-wdc4p4bc 44 27 with with IN cord-271176-wdc4p4bc 44 28 ' ' `` cord-271176-wdc4p4bc 44 29 inactive inactive JJ cord-271176-wdc4p4bc 44 30 ' ' '' cord-271176-wdc4p4bc 44 31 MS MS NNP cord-271176-wdc4p4bc 44 32 . . . cord-271176-wdc4p4bc 45 1 There there EX cord-271176-wdc4p4bc 45 2 were be VBD cord-271176-wdc4p4bc 45 3 also also RB cord-271176-wdc4p4bc 45 4 dramatic dramatic JJ cord-271176-wdc4p4bc 45 5 differences difference NNS cord-271176-wdc4p4bc 45 6 in in IN cord-271176-wdc4p4bc 45 7 viremia viremia NN cord-271176-wdc4p4bc 45 8 . . . cord-271176-wdc4p4bc 46 1 Twenty twenty CD cord-271176-wdc4p4bc 46 2 seven seven CD cord-271176-wdc4p4bc 46 3 out out IN cord-271176-wdc4p4bc 46 4 of of IN cord-271176-wdc4p4bc 46 5 41 41 CD cord-271176-wdc4p4bc 46 6 patients patient NNS cord-271176-wdc4p4bc 46 7 with with IN cord-271176-wdc4p4bc 46 8 MS MS NNP cord-271176-wdc4p4bc 46 9 had have VBD cord-271176-wdc4p4bc 46 10 active active JJ cord-271176-wdc4p4bc 46 11 HHV-6 HHV-6 NNP cord-271176-wdc4p4bc 46 12 viremia viremia NN cord-271176-wdc4p4bc 46 13 , , , cord-271176-wdc4p4bc 46 14 compared compare VBN cord-271176-wdc4p4bc 46 15 with with IN cord-271176-wdc4p4bc 46 16 none none NN cord-271176-wdc4p4bc 46 17 of of IN cord-271176-wdc4p4bc 46 18 the the DT cord-271176-wdc4p4bc 46 19 61 61 CD cord-271176-wdc4p4bc 46 20 controls control NNS cord-271176-wdc4p4bc 46 21 . . . cord-271176-wdc4p4bc 47 1 Other other JJ cord-271176-wdc4p4bc 47 2 investigators investigator NNS cord-271176-wdc4p4bc 47 3 presented present VBD cord-271176-wdc4p4bc 47 4 data datum NNS cord-271176-wdc4p4bc 47 5 supporting support VBG cord-271176-wdc4p4bc 47 6 potential potential JJ cord-271176-wdc4p4bc 47 7 roles role NNS cord-271176-wdc4p4bc 47 8 for for IN cord-271176-wdc4p4bc 47 9 human human JJ cord-271176-wdc4p4bc 47 10 endogenous endogenous JJ cord-271176-wdc4p4bc 47 11 retroviruses retrovirus NNS cord-271176-wdc4p4bc 47 12 ( ( -LRB- cord-271176-wdc4p4bc 47 13 Herve Herve NNP cord-271176-wdc4p4bc 47 14 Perron Perron NNP cord-271176-wdc4p4bc 47 15 , , , cord-271176-wdc4p4bc 47 16 Biomerieux Biomerieux NNP cord-271176-wdc4p4bc 47 17 SA SA NNP cord-271176-wdc4p4bc 47 18 , , , cord-271176-wdc4p4bc 47 19 Lyon Lyon NNP cord-271176-wdc4p4bc 47 20 , , , cord-271176-wdc4p4bc 47 21 France France NNP cord-271176-wdc4p4bc 47 22 ) ) -RRB- cord-271176-wdc4p4bc 47 23 , , , cord-271176-wdc4p4bc 47 24 and and CC cord-271176-wdc4p4bc 47 25 delayed delay VBN cord-271176-wdc4p4bc 47 26 exposure exposure NN cord-271176-wdc4p4bc 47 27 to to IN cord-271176-wdc4p4bc 47 28 Epstein Epstein NNP cord-271176-wdc4p4bc 47 29 - - HYPH cord-271176-wdc4p4bc 47 30 Barr Barr NNP cord-271176-wdc4p4bc 47 31 virus virus NN cord-271176-wdc4p4bc 47 32 ( ( -LRB- cord-271176-wdc4p4bc 47 33 Tove Tove NNP cord-271176-wdc4p4bc 47 34 Christensen Christensen NNP cord-271176-wdc4p4bc 47 35 and and CC cord-271176-wdc4p4bc 47 36 Sven Sven NNP cord-271176-wdc4p4bc 47 37 Haar Haar NNP cord-271176-wdc4p4bc 47 38 , , , cord-271176-wdc4p4bc 47 39 Aarhus Aarhus NNP cord-271176-wdc4p4bc 47 40 University University NNP cord-271176-wdc4p4bc 47 41 , , , cord-271176-wdc4p4bc 47 42 Aarhus Aarhus NNP cord-271176-wdc4p4bc 47 43 , , , cord-271176-wdc4p4bc 47 44 Denmark Denmark NNP cord-271176-wdc4p4bc 47 45 ) ) -RRB- cord-271176-wdc4p4bc 47 46 as as IN cord-271176-wdc4p4bc 47 47 potential potential JJ cord-271176-wdc4p4bc 47 48 triggers trigger NNS cord-271176-wdc4p4bc 47 49 4 4 CD cord-271176-wdc4p4bc 47 50 , , , cord-271176-wdc4p4bc 47 51 5 5 CD cord-271176-wdc4p4bc 47 52 . . . cord-271176-wdc4p4bc 48 1 However however RB cord-271176-wdc4p4bc 48 2 , , , cord-271176-wdc4p4bc 48 3 as as IN cord-271176-wdc4p4bc 48 4 with with IN cord-271176-wdc4p4bc 48 5 many many JJ cord-271176-wdc4p4bc 48 6 such such JJ cord-271176-wdc4p4bc 48 7 reports report NNS cord-271176-wdc4p4bc 48 8 , , , cord-271176-wdc4p4bc 48 9 in in IN cord-271176-wdc4p4bc 48 10 most most JJS cord-271176-wdc4p4bc 48 11 individuals individual NNS cord-271176-wdc4p4bc 48 12 there there EX cord-271176-wdc4p4bc 48 13 is be VBZ cord-271176-wdc4p4bc 48 14 evidence evidence NN cord-271176-wdc4p4bc 48 15 of of IN cord-271176-wdc4p4bc 48 16 prior prior JJ cord-271176-wdc4p4bc 48 17 or or CC cord-271176-wdc4p4bc 48 18 current current JJ cord-271176-wdc4p4bc 48 19 infection infection NN cord-271176-wdc4p4bc 48 20 with with IN cord-271176-wdc4p4bc 48 21 these these DT cord-271176-wdc4p4bc 48 22 agents agent NNS cord-271176-wdc4p4bc 48 23 whether whether IN cord-271176-wdc4p4bc 48 24 or or CC cord-271176-wdc4p4bc 48 25 not not RB cord-271176-wdc4p4bc 48 26 they -PRON- PRP cord-271176-wdc4p4bc 48 27 have have VBP cord-271176-wdc4p4bc 48 28 MS MS NNP cord-271176-wdc4p4bc 48 29 , , , cord-271176-wdc4p4bc 48 30 and and CC cord-271176-wdc4p4bc 48 31 there there EX cord-271176-wdc4p4bc 48 32 are be VBP cord-271176-wdc4p4bc 48 33 no no DT cord-271176-wdc4p4bc 48 34 moredefinitive moredefinitive JJ cord-271176-wdc4p4bc 48 35 tests test NNS cord-271176-wdc4p4bc 48 36 such such JJ cord-271176-wdc4p4bc 48 37 as as IN cord-271176-wdc4p4bc 48 38 viremia viremia NN cord-271176-wdc4p4bc 48 39 or or CC cord-271176-wdc4p4bc 48 40 analysis analysis NN cord-271176-wdc4p4bc 48 41 of of IN cord-271176-wdc4p4bc 48 42 oligoclonal oligoclonal JJ cord-271176-wdc4p4bc 48 43 bands band NNS cord-271176-wdc4p4bc 48 44 to to TO cord-271176-wdc4p4bc 48 45 differentiate differentiate VB cord-271176-wdc4p4bc 48 46 patients patient NNS cord-271176-wdc4p4bc 48 47 with with IN cord-271176-wdc4p4bc 48 48 MS MS NNP cord-271176-wdc4p4bc 48 49 from from IN cord-271176-wdc4p4bc 48 50 those those DT cord-271176-wdc4p4bc 48 51 with with IN cord-271176-wdc4p4bc 48 52 other other JJ cord-271176-wdc4p4bc 48 53 diseases disease NNS cord-271176-wdc4p4bc 48 54 . . . cord-271176-wdc4p4bc 49 1 Further further JJ cord-271176-wdc4p4bc 49 2 research research NN cord-271176-wdc4p4bc 49 3 will will MD cord-271176-wdc4p4bc 49 4 be be VB cord-271176-wdc4p4bc 49 5 needed need VBN cord-271176-wdc4p4bc 49 6 in in IN cord-271176-wdc4p4bc 49 7 order order NN cord-271176-wdc4p4bc 49 8 to to TO cord-271176-wdc4p4bc 49 9 clarify clarify VB cord-271176-wdc4p4bc 49 10 and and CC cord-271176-wdc4p4bc 49 11 reconcile reconcile VB cord-271176-wdc4p4bc 49 12 these these DT cord-271176-wdc4p4bc 49 13 potentially potentially RB cord-271176-wdc4p4bc 49 14 conflicting conflicting JJ cord-271176-wdc4p4bc 49 15 findings finding NNS cord-271176-wdc4p4bc 49 16 , , , cord-271176-wdc4p4bc 49 17 as as IN cord-271176-wdc4p4bc 49 18 several several JJ cord-271176-wdc4p4bc 49 19 presentations presentation NNS cord-271176-wdc4p4bc 49 20 outlined outline VBD cord-271176-wdc4p4bc 49 21 an an DT cord-271176-wdc4p4bc 49 22 association association NN cord-271176-wdc4p4bc 49 23 with with IN cord-271176-wdc4p4bc 49 24 a a DT cord-271176-wdc4p4bc 49 25 specific specific JJ cord-271176-wdc4p4bc 49 26 agent agent NN cord-271176-wdc4p4bc 49 27 in in IN cord-271176-wdc4p4bc 49 28 over over IN cord-271176-wdc4p4bc 49 29 half half NN cord-271176-wdc4p4bc 49 30 of of IN cord-271176-wdc4p4bc 49 31 the the DT cord-271176-wdc4p4bc 49 32 cases case NNS cord-271176-wdc4p4bc 49 33 . . . cord-271176-wdc4p4bc 50 1 It -PRON- PRP cord-271176-wdc4p4bc 50 2 is be VBZ cord-271176-wdc4p4bc 50 3 entirely entirely RB cord-271176-wdc4p4bc 50 4 possible possible JJ cord-271176-wdc4p4bc 50 5 that that IN cord-271176-wdc4p4bc 50 6 multiple multiple JJ cord-271176-wdc4p4bc 50 7 microorganisms microorganism NNS cord-271176-wdc4p4bc 50 8 are be VBP cord-271176-wdc4p4bc 50 9 each each DT cord-271176-wdc4p4bc 50 10 responsible responsible JJ cord-271176-wdc4p4bc 50 11 for for IN cord-271176-wdc4p4bc 50 12 a a DT cord-271176-wdc4p4bc 50 13 small small JJ cord-271176-wdc4p4bc 50 14 proportion proportion NN cord-271176-wdc4p4bc 50 15 of of IN cord-271176-wdc4p4bc 50 16 this this DT cord-271176-wdc4p4bc 50 17 disease disease NN cord-271176-wdc4p4bc 50 18 , , , cord-271176-wdc4p4bc 50 19 perhaps perhaps RB cord-271176-wdc4p4bc 50 20 indirectly indirectly RB cord-271176-wdc4p4bc 50 21 , , , cord-271176-wdc4p4bc 50 22 by by IN cord-271176-wdc4p4bc 50 23 inducing induce VBG cord-271176-wdc4p4bc 50 24 immune immune JJ cord-271176-wdc4p4bc 50 25 responses response NNS cord-271176-wdc4p4bc 50 26 that that WDT cord-271176-wdc4p4bc 50 27 result result VBP cord-271176-wdc4p4bc 50 28 in in IN cord-271176-wdc4p4bc 50 29 an an DT cord-271176-wdc4p4bc 50 30 immune immune JJ cord-271176-wdc4p4bc 50 31 attack attack NN cord-271176-wdc4p4bc 50 32 on on IN cord-271176-wdc4p4bc 50 33 the the DT cord-271176-wdc4p4bc 50 34 CNS CNS NNP cord-271176-wdc4p4bc 50 35 , , , cord-271176-wdc4p4bc 50 36 without without IN cord-271176-wdc4p4bc 50 37 persisting persist VBG cord-271176-wdc4p4bc 50 38 in in IN cord-271176-wdc4p4bc 50 39 the the DT cord-271176-wdc4p4bc 50 40 affected affected JJ cord-271176-wdc4p4bc 50 41 patient patient NN cord-271176-wdc4p4bc 50 42 . . . cord-271176-wdc4p4bc 51 1 Several several JJ cord-271176-wdc4p4bc 51 2 animal animal NN cord-271176-wdc4p4bc 51 3 models model NNS cord-271176-wdc4p4bc 51 4 of of IN cord-271176-wdc4p4bc 51 5 virally virally RB cord-271176-wdc4p4bc 51 6 induced induce VBN cord-271176-wdc4p4bc 51 7 demyelination demyelination NN cord-271176-wdc4p4bc 51 8 , , , cord-271176-wdc4p4bc 51 9 particularly particularly RB cord-271176-wdc4p4bc 51 10 those those DT cord-271176-wdc4p4bc 51 11 associated associate VBN cord-271176-wdc4p4bc 51 12 with with IN cord-271176-wdc4p4bc 51 13 murine murine JJ cord-271176-wdc4p4bc 51 14 coronaviruses coronaviruse NNS cord-271176-wdc4p4bc 51 15 or or CC cord-271176-wdc4p4bc 51 16 with with IN cord-271176-wdc4p4bc 51 17 Theiler Theiler NNP cord-271176-wdc4p4bc 51 18 's 's POS cord-271176-wdc4p4bc 51 19 murine murine JJ cord-271176-wdc4p4bc 51 20 encephalomyelitis encephalomyelitis NN cord-271176-wdc4p4bc 51 21 virus virus NN cord-271176-wdc4p4bc 51 22 ( ( -LRB- cord-271176-wdc4p4bc 51 23 TMEV TMEV NNP cord-271176-wdc4p4bc 51 24 ) ) -RRB- cord-271176-wdc4p4bc 51 25 , , , cord-271176-wdc4p4bc 51 26 support support VBP cord-271176-wdc4p4bc 51 27 such such PDT cord-271176-wdc4p4bc 51 28 an an DT cord-271176-wdc4p4bc 51 29 idea idea NN cord-271176-wdc4p4bc 51 30 . . . cord-271176-wdc4p4bc 52 1 In in IN cord-271176-wdc4p4bc 52 2 these these DT cord-271176-wdc4p4bc 52 3 models model NNS cord-271176-wdc4p4bc 52 4 , , , cord-271176-wdc4p4bc 52 5 demyelination demyelination NN cord-271176-wdc4p4bc 52 6 is be VBZ cord-271176-wdc4p4bc 52 7 related relate VBN cord-271176-wdc4p4bc 52 8 to to IN cord-271176-wdc4p4bc 52 9 the the DT cord-271176-wdc4p4bc 52 10 presence presence NN cord-271176-wdc4p4bc 52 11 of of IN cord-271176-wdc4p4bc 52 12 an an DT cord-271176-wdc4p4bc 52 13 identified identify VBN cord-271176-wdc4p4bc 52 14 virus virus NN cord-271176-wdc4p4bc 52 15 within within IN cord-271176-wdc4p4bc 52 16 the the DT cord-271176-wdc4p4bc 52 17 CNS CNS NNP cord-271176-wdc4p4bc 52 18 ; ; : cord-271176-wdc4p4bc 52 19 in in IN cord-271176-wdc4p4bc 52 20 TMEV TMEV NNP cord-271176-wdc4p4bc 52 21 - - HYPH cord-271176-wdc4p4bc 52 22 mediated mediate VBN cord-271176-wdc4p4bc 52 23 disease disease NN cord-271176-wdc4p4bc 52 24 , , , cord-271176-wdc4p4bc 52 25 the the DT cord-271176-wdc4p4bc 52 26 extent extent NN cord-271176-wdc4p4bc 52 27 of of IN cord-271176-wdc4p4bc 52 28 demyelination demyelination NN cord-271176-wdc4p4bc 52 29 depends depend VBZ cord-271176-wdc4p4bc 52 30 not not RB cord-271176-wdc4p4bc 52 31 only only RB cord-271176-wdc4p4bc 52 32 on on IN cord-271176-wdc4p4bc 52 33 viral viral JJ cord-271176-wdc4p4bc 52 34 load load NN cord-271176-wdc4p4bc 52 35 but but CC cord-271176-wdc4p4bc 52 36 also also RB cord-271176-wdc4p4bc 52 37 on on IN cord-271176-wdc4p4bc 52 38 a a DT cord-271176-wdc4p4bc 52 39 locus locus NN cord-271176-wdc4p4bc 52 40 on on IN cord-271176-wdc4p4bc 52 41 mouse mouse NN cord-271176-wdc4p4bc 52 42 chromosome chromosome NN cord-271176-wdc4p4bc 52 43 11 11 CD cord-271176-wdc4p4bc 53 1 ( ( -LRB- cord-271176-wdc4p4bc 53 2 Michel Michel NNP cord-271176-wdc4p4bc 53 3 Brahic Brahic NNP cord-271176-wdc4p4bc 53 4 , , , cord-271176-wdc4p4bc 53 5 Institut Institut NNP cord-271176-wdc4p4bc 53 6 Pasteur Pasteur NNP cord-271176-wdc4p4bc 53 7 , , , cord-271176-wdc4p4bc 53 8 Paris Paris NNP cord-271176-wdc4p4bc 53 9 , , , cord-271176-wdc4p4bc 53 10 France France NNP cord-271176-wdc4p4bc 53 11 ) ) -RRB- cord-271176-wdc4p4bc 53 12 . . . cord-271176-wdc4p4bc 54 1 Although although IN cord-271176-wdc4p4bc 54 2 an an DT cord-271176-wdc4p4bc 54 3 intact intact JJ cord-271176-wdc4p4bc 54 4 immune immune JJ cord-271176-wdc4p4bc 54 5 system system NN cord-271176-wdc4p4bc 54 6 is be VBZ cord-271176-wdc4p4bc 54 7 necessary necessary JJ cord-271176-wdc4p4bc 54 8 for for IN cord-271176-wdc4p4bc 54 9 the the DT cord-271176-wdc4p4bc 54 10 disease disease NN cord-271176-wdc4p4bc 54 11 to to TO cord-271176-wdc4p4bc 54 12 manifest manifest VB cord-271176-wdc4p4bc 54 13 in in IN cord-271176-wdc4p4bc 54 14 its -PRON- PRP$ cord-271176-wdc4p4bc 54 15 full full JJ cord-271176-wdc4p4bc 54 16 form form NN cord-271176-wdc4p4bc 54 17 , , , cord-271176-wdc4p4bc 54 18 which which WDT cord-271176-wdc4p4bc 54 19 arm arm NN cord-271176-wdc4p4bc 54 20 of of IN cord-271176-wdc4p4bc 54 21 the the DT cord-271176-wdc4p4bc 54 22 immune immune JJ cord-271176-wdc4p4bc 54 23 response response NN cord-271176-wdc4p4bc 54 24 is be VBZ cord-271176-wdc4p4bc 54 25 most most RBS cord-271176-wdc4p4bc 54 26 critical critical JJ cord-271176-wdc4p4bc 54 27 varies varie NNS cord-271176-wdc4p4bc 54 28 from from IN cord-271176-wdc4p4bc 54 29 model model NN cord-271176-wdc4p4bc 54 30 to to IN cord-271176-wdc4p4bc 54 31 model model NN cord-271176-wdc4p4bc 54 32 , , , cord-271176-wdc4p4bc 54 33 and and CC cord-271176-wdc4p4bc 54 34 even even RB cord-271176-wdc4p4bc 54 35 within within IN cord-271176-wdc4p4bc 54 36 models model NNS cord-271176-wdc4p4bc 54 37 , , , cord-271176-wdc4p4bc 54 38 apparently apparently RB cord-271176-wdc4p4bc 54 39 depending depend VBG cord-271176-wdc4p4bc 54 40 on on IN cord-271176-wdc4p4bc 54 41 the the DT cord-271176-wdc4p4bc 54 42 viral viral JJ cord-271176-wdc4p4bc 54 43 strain strain NN cord-271176-wdc4p4bc 54 44 . . . cord-271176-wdc4p4bc 55 1 Demyelination Demyelination NNP cord-271176-wdc4p4bc 55 2 after after IN cord-271176-wdc4p4bc 55 3 TMEV TMEV NNP cord-271176-wdc4p4bc 55 4 infection infection NN cord-271176-wdc4p4bc 55 5 of of IN cord-271176-wdc4p4bc 55 6 mice mouse NNS cord-271176-wdc4p4bc 55 7 transgenic transgenic JJ cord-271176-wdc4p4bc 55 8 for for IN cord-271176-wdc4p4bc 55 9 a a DT cord-271176-wdc4p4bc 55 10 human human JJ cord-271176-wdc4p4bc 55 11 leukocyte leukocyte NN cord-271176-wdc4p4bc 55 12 antigen antigen NN cord-271176-wdc4p4bc 55 13 ( ( -LRB- cord-271176-wdc4p4bc 55 14 HLA HLA NNP cord-271176-wdc4p4bc 55 15 ) ) -RRB- cord-271176-wdc4p4bc 55 16 was be VBD cord-271176-wdc4p4bc 55 17 shown show VBN cord-271176-wdc4p4bc 55 18 to to TO cord-271176-wdc4p4bc 55 19 be be VB cord-271176-wdc4p4bc 55 20 modulated modulate VBN cord-271176-wdc4p4bc 55 21 by by IN cord-271176-wdc4p4bc 55 22 the the DT cord-271176-wdc4p4bc 55 23 HLA HLA NNP cord-271176-wdc4p4bc 55 24 transgene transgene NN cord-271176-wdc4p4bc 55 25 ( ( -LRB- cord-271176-wdc4p4bc 55 26 Moses Moses NNP cord-271176-wdc4p4bc 55 27 Rodriguez Rodriguez NNP cord-271176-wdc4p4bc 55 28 , , , cord-271176-wdc4p4bc 55 29 Mayo Mayo NNP cord-271176-wdc4p4bc 55 30 Clinic Clinic NNP cord-271176-wdc4p4bc 55 31 , , , cord-271176-wdc4p4bc 55 32 Rochester Rochester NNP cord-271176-wdc4p4bc 55 33 , , , cord-271176-wdc4p4bc 55 34 MN MN NNP cord-271176-wdc4p4bc 55 35 , , , cord-271176-wdc4p4bc 55 36 USA USA NNP cord-271176-wdc4p4bc 55 37 ) ) -RRB- cord-271176-wdc4p4bc 55 38 , , , cord-271176-wdc4p4bc 55 39 a a DT cord-271176-wdc4p4bc 55 40 finding finding NN cord-271176-wdc4p4bc 55 41 that that WDT cord-271176-wdc4p4bc 55 42 might may MD cord-271176-wdc4p4bc 55 43 relate relate VB cord-271176-wdc4p4bc 55 44 to to IN cord-271176-wdc4p4bc 55 45 the the DT cord-271176-wdc4p4bc 55 46 preponderance preponderance NN cord-271176-wdc4p4bc 55 47 of of IN cord-271176-wdc4p4bc 55 48 certain certain JJ cord-271176-wdc4p4bc 55 49 HLA HLA NNP cord-271176-wdc4p4bc 55 50 subtypes subtype NNS cord-271176-wdc4p4bc 55 51 in in IN cord-271176-wdc4p4bc 55 52 MS MS NNP cord-271176-wdc4p4bc 55 53 . . . cord-271176-wdc4p4bc 56 1 Interestingly interestingly RB cord-271176-wdc4p4bc 56 2 , , , cord-271176-wdc4p4bc 56 3 by by IN cord-271176-wdc4p4bc 56 4 careful careful JJ cord-271176-wdc4p4bc 56 5 injection injection NN cord-271176-wdc4p4bc 56 6 , , , cord-271176-wdc4p4bc 56 7 foreign foreign JJ cord-271176-wdc4p4bc 56 8 antigens antigen NNS cord-271176-wdc4p4bc 56 9 can can MD cord-271176-wdc4p4bc 56 10 be be VB cord-271176-wdc4p4bc 56 11 introduced introduce VBN cord-271176-wdc4p4bc 56 12 into into IN cord-271176-wdc4p4bc 56 13 the the DT cord-271176-wdc4p4bc 56 14 brain brain NN cord-271176-wdc4p4bc 56 15 of of IN cord-271176-wdc4p4bc 56 16 mice mouse NNS cord-271176-wdc4p4bc 56 17 and and CC cord-271176-wdc4p4bc 56 18 not not RB cord-271176-wdc4p4bc 56 19 be be VB cord-271176-wdc4p4bc 56 20 ' ' `` cord-271176-wdc4p4bc 56 21 seen see VBN cord-271176-wdc4p4bc 56 22 ' ' '' cord-271176-wdc4p4bc 56 23 by by IN cord-271176-wdc4p4bc 56 24 the the DT cord-271176-wdc4p4bc 56 25 immune immune JJ cord-271176-wdc4p4bc 56 26 system system NN cord-271176-wdc4p4bc 56 27 until until IN cord-271176-wdc4p4bc 56 28 after after IN cord-271176-wdc4p4bc 56 29 a a DT cord-271176-wdc4p4bc 56 30 subsequent subsequent JJ cord-271176-wdc4p4bc 56 31 peripheral peripheral JJ cord-271176-wdc4p4bc 56 32 challenge challenge NN cord-271176-wdc4p4bc 56 33 , , , cord-271176-wdc4p4bc 56 34 which which WDT cord-271176-wdc4p4bc 56 35 leads lead VBZ cord-271176-wdc4p4bc 56 36 to to IN cord-271176-wdc4p4bc 56 37 detection detection NN cord-271176-wdc4p4bc 56 38 and and CC cord-271176-wdc4p4bc 56 39 commencement commencement NN cord-271176-wdc4p4bc 56 40 of of IN cord-271176-wdc4p4bc 56 41 an an DT cord-271176-wdc4p4bc 56 42 immunopathological immunopathological JJ cord-271176-wdc4p4bc 56 43 process process NN cord-271176-wdc4p4bc 57 1 ( ( -LRB- cord-271176-wdc4p4bc 57 2 Hugh Hugh NNP cord-271176-wdc4p4bc 57 3 Perry Perry NNP cord-271176-wdc4p4bc 57 4 , , , cord-271176-wdc4p4bc 57 5 University University NNP cord-271176-wdc4p4bc 57 6 of of IN cord-271176-wdc4p4bc 57 7 Southampton Southampton NNP cord-271176-wdc4p4bc 57 8 , , , cord-271176-wdc4p4bc 57 9 Southampton Southampton NNP cord-271176-wdc4p4bc 57 10 , , , cord-271176-wdc4p4bc 57 11 UK UK NNP cord-271176-wdc4p4bc 57 12 ) ) -RRB- cord-271176-wdc4p4bc 57 13 . . . cord-271176-wdc4p4bc 58 1 Whether whether IN cord-271176-wdc4p4bc 58 2 or or CC cord-271176-wdc4p4bc 58 3 not not RB cord-271176-wdc4p4bc 58 4 a a DT cord-271176-wdc4p4bc 58 5 single single JJ cord-271176-wdc4p4bc 58 6 agent agent NN cord-271176-wdc4p4bc 58 7 is be VBZ cord-271176-wdc4p4bc 58 8 indeed indeed RB cord-271176-wdc4p4bc 58 9 responsible responsible JJ cord-271176-wdc4p4bc 58 10 for for IN cord-271176-wdc4p4bc 58 11 this this DT cord-271176-wdc4p4bc 58 12 disease disease NN cord-271176-wdc4p4bc 58 13 , , , cord-271176-wdc4p4bc 58 14 there there EX cord-271176-wdc4p4bc 58 15 are be VBP cord-271176-wdc4p4bc 58 16 multiple multiple JJ cord-271176-wdc4p4bc 58 17 ways way NNS cord-271176-wdc4p4bc 58 18 in in IN cord-271176-wdc4p4bc 58 19 which which WDT cord-271176-wdc4p4bc 58 20 an an DT cord-271176-wdc4p4bc 58 21 infectious infectious JJ cord-271176-wdc4p4bc 58 22 agent agent NN cord-271176-wdc4p4bc 58 23 could could MD cord-271176-wdc4p4bc 58 24 be be VB cord-271176-wdc4p4bc 58 25 associated associate VBN cord-271176-wdc4p4bc 58 26 with with IN cord-271176-wdc4p4bc 58 27 , , , cord-271176-wdc4p4bc 58 28 or or CC cord-271176-wdc4p4bc 58 29 trigger trigger NN cord-271176-wdc4p4bc 58 30 , , , cord-271176-wdc4p4bc 58 31 MS MS NNP cord-271176-wdc4p4bc 58 32 . . . cord-271176-wdc4p4bc 59 1 In in IN cord-271176-wdc4p4bc 59 2 some some DT cord-271176-wdc4p4bc 59 3 of of IN cord-271176-wdc4p4bc 59 4 these these DT cord-271176-wdc4p4bc 59 5 , , , cord-271176-wdc4p4bc 59 6 the the DT cord-271176-wdc4p4bc 59 7 microorganism microorganism NN cord-271176-wdc4p4bc 59 8 might may MD cord-271176-wdc4p4bc 59 9 no no RB cord-271176-wdc4p4bc 59 10 longer longer RB cord-271176-wdc4p4bc 59 11 be be VB cord-271176-wdc4p4bc 59 12 present present JJ cord-271176-wdc4p4bc 59 13 by by IN cord-271176-wdc4p4bc 59 14 the the DT cord-271176-wdc4p4bc 59 15 time time NN cord-271176-wdc4p4bc 59 16 the the DT cord-271176-wdc4p4bc 59 17 disease disease NN cord-271176-wdc4p4bc 59 18 manifests manifest VBZ cord-271176-wdc4p4bc 59 19 but but CC cord-271176-wdc4p4bc 59 20 , , , cord-271176-wdc4p4bc 59 21 for for IN cord-271176-wdc4p4bc 59 22 example example NN cord-271176-wdc4p4bc 59 23 , , , cord-271176-wdc4p4bc 59 24 it -PRON- PRP cord-271176-wdc4p4bc 59 25 affects affect VBZ cord-271176-wdc4p4bc 59 26 the the DT cord-271176-wdc4p4bc 59 27 CNS CNS NNP cord-271176-wdc4p4bc 59 28 by by IN cord-271176-wdc4p4bc 59 29 changing change VBG cord-271176-wdc4p4bc 59 30 the the DT cord-271176-wdc4p4bc 59 31 intrathecal intrathecal JJ cord-271176-wdc4p4bc 59 32 cytokine cytokine NN cord-271176-wdc4p4bc 59 33 environment environment NN cord-271176-wdc4p4bc 59 34 and and CC cord-271176-wdc4p4bc 59 35 promoting promote VBG cord-271176-wdc4p4bc 59 36 pro pro JJ cord-271176-wdc4p4bc 59 37 - - JJ cord-271176-wdc4p4bc 59 38 inflammatory inflammatory JJ cord-271176-wdc4p4bc 59 39 reactions reaction NNS cord-271176-wdc4p4bc 59 40 or or CC cord-271176-wdc4p4bc 59 41 by by IN cord-271176-wdc4p4bc 59 42 stimulating stimulate VBG cord-271176-wdc4p4bc 59 43 autoreactive autoreactive JJ cord-271176-wdc4p4bc 59 44 T t NN cord-271176-wdc4p4bc 59 45 cells cell NNS cord-271176-wdc4p4bc 59 46 . . . cord-271176-wdc4p4bc 60 1 Matthias Matthias NNP cord-271176-wdc4p4bc 60 2 Von Von NNP cord-271176-wdc4p4bc 60 3 Herrath Herrath NNP cord-271176-wdc4p4bc 60 4 ( ( -LRB- cord-271176-wdc4p4bc 60 5 Scripps Scripps NNP cord-271176-wdc4p4bc 60 6 Clinic Clinic NNP cord-271176-wdc4p4bc 60 7 , , , cord-271176-wdc4p4bc 60 8 San San NNP cord-271176-wdc4p4bc 60 9 Diego Diego NNP cord-271176-wdc4p4bc 60 10 , , , cord-271176-wdc4p4bc 60 11 CA CA NNP cord-271176-wdc4p4bc 60 12 , , , cord-271176-wdc4p4bc 60 13 USA USA NNP cord-271176-wdc4p4bc 60 14 ) ) -RRB- cord-271176-wdc4p4bc 60 15 indicated indicate VBD cord-271176-wdc4p4bc 60 16 that that IN cord-271176-wdc4p4bc 60 17 , , , cord-271176-wdc4p4bc 60 18 in in IN cord-271176-wdc4p4bc 60 19 an an DT cord-271176-wdc4p4bc 60 20 autoimmune autoimmune JJ cord-271176-wdc4p4bc 60 21 diabetes diabetes NN cord-271176-wdc4p4bc 60 22 model model NN cord-271176-wdc4p4bc 60 23 , , , cord-271176-wdc4p4bc 60 24 the the DT cord-271176-wdc4p4bc 60 25 growth growth NN cord-271176-wdc4p4bc 60 26 kinetics kinetic NNS cord-271176-wdc4p4bc 60 27 of of IN cord-271176-wdc4p4bc 60 28 different different JJ cord-271176-wdc4p4bc 60 29 strains strain NNS cord-271176-wdc4p4bc 60 30 of of IN cord-271176-wdc4p4bc 60 31 lymphocytic lymphocytic JJ cord-271176-wdc4p4bc 60 32 choriomeningitis choriomeningitis NNP cord-271176-wdc4p4bc 60 33 virus virus NN cord-271176-wdc4p4bc 60 34 determined determine VBD cord-271176-wdc4p4bc 60 35 whether whether IN cord-271176-wdc4p4bc 60 36 the the DT cord-271176-wdc4p4bc 60 37 disease disease NN cord-271176-wdc4p4bc 60 38 was be VBD cord-271176-wdc4p4bc 60 39 exacerbated exacerbate VBN cord-271176-wdc4p4bc 60 40 by by IN cord-271176-wdc4p4bc 60 41 a a DT cord-271176-wdc4p4bc 60 42 second second JJ cord-271176-wdc4p4bc 60 43 peripheral peripheral JJ cord-271176-wdc4p4bc 60 44 challenge challenge NN cord-271176-wdc4p4bc 60 45 or or CC cord-271176-wdc4p4bc 60 46 whether whether IN cord-271176-wdc4p4bc 60 47 this this DT cord-271176-wdc4p4bc 60 48 was be VBD cord-271176-wdc4p4bc 60 49 , , , cord-271176-wdc4p4bc 60 50 in in IN cord-271176-wdc4p4bc 60 51 fact fact NN cord-271176-wdc4p4bc 60 52 , , , cord-271176-wdc4p4bc 60 53 protective protective JJ cord-271176-wdc4p4bc 60 54 . . . cord-271176-wdc4p4bc 61 1 Balances balance NNS cord-271176-wdc4p4bc 61 2 between between IN cord-271176-wdc4p4bc 61 3 immune immune JJ cord-271176-wdc4p4bc 61 4 reactions reaction NNS cord-271176-wdc4p4bc 61 5 also also RB cord-271176-wdc4p4bc 61 6 produce produce VBP cord-271176-wdc4p4bc 61 7 different different JJ cord-271176-wdc4p4bc 61 8 responses response NNS cord-271176-wdc4p4bc 61 9 in in IN cord-271176-wdc4p4bc 61 10 Borna Borna NNP cord-271176-wdc4p4bc 61 11 virus virus NN cord-271176-wdc4p4bc 61 12 infection infection NN cord-271176-wdc4p4bc 61 13 in in IN cord-271176-wdc4p4bc 61 14 rats rat NNS cord-271176-wdc4p4bc 62 1 ( ( -LRB- cord-271176-wdc4p4bc 62 2 Luther Luther NNP cord-271176-wdc4p4bc 62 3 Stitz Stitz NNP cord-271176-wdc4p4bc 62 4 , , , cord-271176-wdc4p4bc 62 5 Institute Institute NNP cord-271176-wdc4p4bc 62 6 of of IN cord-271176-wdc4p4bc 62 7 Animal Animal NNP cord-271176-wdc4p4bc 62 8 Health Health NNP cord-271176-wdc4p4bc 62 9 , , , cord-271176-wdc4p4bc 62 10 Tüebingen Tüebingen NNP cord-271176-wdc4p4bc 62 11 , , , cord-271176-wdc4p4bc 62 12 Germany Germany NNP cord-271176-wdc4p4bc 62 13 ) ) -RRB- cord-271176-wdc4p4bc 62 14 . . . cord-271176-wdc4p4bc 63 1 One one CD cord-271176-wdc4p4bc 63 2 of of IN cord-271176-wdc4p4bc 63 3 the the DT cord-271176-wdc4p4bc 63 4 more more RBR cord-271176-wdc4p4bc 63 5 popular popular JJ cord-271176-wdc4p4bc 63 6 arguments argument NNS cord-271176-wdc4p4bc 63 7 has have VBZ cord-271176-wdc4p4bc 63 8 been be VBN cord-271176-wdc4p4bc 63 9 that that IN cord-271176-wdc4p4bc 63 10 a a DT cord-271176-wdc4p4bc 63 11 microorganism microorganism NN cord-271176-wdc4p4bc 63 12 could could MD cord-271176-wdc4p4bc 63 13 stimulate stimulate VB cord-271176-wdc4p4bc 63 14 an an DT cord-271176-wdc4p4bc 63 15 autoimmune autoimmune JJ cord-271176-wdc4p4bc 63 16 response response NN cord-271176-wdc4p4bc 63 17 by by IN cord-271176-wdc4p4bc 63 18 mimicking mimic VBG cord-271176-wdc4p4bc 63 19 an an DT cord-271176-wdc4p4bc 63 20 endogenous endogenous JJ cord-271176-wdc4p4bc 63 21 antigen antigen NN cord-271176-wdc4p4bc 63 22 ( ( -LRB- cord-271176-wdc4p4bc 63 23 antigenic antigenic JJ cord-271176-wdc4p4bc 63 24 mimicry mimicry NN cord-271176-wdc4p4bc 63 25 ) ) -RRB- cord-271176-wdc4p4bc 63 26 ( ( -LRB- cord-271176-wdc4p4bc 63 27 Uwe Uwe NNP cord-271176-wdc4p4bc 63 28 Liebert Liebert NNP cord-271176-wdc4p4bc 63 29 , , , cord-271176-wdc4p4bc 63 30 University University NNP cord-271176-wdc4p4bc 63 31 of of IN cord-271176-wdc4p4bc 63 32 Leipzig Leipzig NNP cord-271176-wdc4p4bc 63 33 , , , cord-271176-wdc4p4bc 63 34 Leipzig Leipzig NNP cord-271176-wdc4p4bc 63 35 , , , cord-271176-wdc4p4bc 63 36 Germany Germany NNP cord-271176-wdc4p4bc 63 37 ; ; : cord-271176-wdc4p4bc 63 38 Henry Henry NNP cord-271176-wdc4p4bc 63 39 McFarland McFarland NNP cord-271176-wdc4p4bc 63 40 , , , cord-271176-wdc4p4bc 63 41 National National NNP cord-271176-wdc4p4bc 63 42 Institutes Institutes NNPS cord-271176-wdc4p4bc 63 43 of of IN cord-271176-wdc4p4bc 63 44 Health Health NNP cord-271176-wdc4p4bc 63 45 , , , cord-271176-wdc4p4bc 63 46 Bethesda Bethesda NNP cord-271176-wdc4p4bc 63 47 , , , cord-271176-wdc4p4bc 63 48 MD MD NNP cord-271176-wdc4p4bc 63 49 , , , cord-271176-wdc4p4bc 63 50 USA USA NNP cord-271176-wdc4p4bc 63 51 ) ) -RRB- cord-271176-wdc4p4bc 63 52 ; ; , cord-271176-wdc4p4bc 63 53 circumstantial circumstantial JJ cord-271176-wdc4p4bc 63 54 evidence evidence NN cord-271176-wdc4p4bc 63 55 indicates indicate VBZ cord-271176-wdc4p4bc 63 56 that that IN cord-271176-wdc4p4bc 63 57 such such PDT cord-271176-wdc4p4bc 63 58 a a DT cord-271176-wdc4p4bc 63 59 mechanism mechanism NN cord-271176-wdc4p4bc 63 60 could could MD cord-271176-wdc4p4bc 63 61 lead lead VB cord-271176-wdc4p4bc 63 62 to to IN cord-271176-wdc4p4bc 63 63 the the DT cord-271176-wdc4p4bc 63 64 development development NN cord-271176-wdc4p4bc 63 65 of of IN cord-271176-wdc4p4bc 63 66 autoimmune autoimmune JJ cord-271176-wdc4p4bc 63 67 , , , cord-271176-wdc4p4bc 63 68 reactive reactive JJ cord-271176-wdc4p4bc 63 69 T t NN cord-271176-wdc4p4bc 63 70 - - HYPH cord-271176-wdc4p4bc 63 71 cell cell NN cord-271176-wdc4p4bc 63 72 clones clone NNS cord-271176-wdc4p4bc 63 73 6 6 CD cord-271176-wdc4p4bc 63 74 , , , cord-271176-wdc4p4bc 63 75 7 7 CD cord-271176-wdc4p4bc 63 76 . . . cord-271176-wdc4p4bc 64 1 Alternatively alternatively RB cord-271176-wdc4p4bc 64 2 , , , cord-271176-wdc4p4bc 64 3 an an DT cord-271176-wdc4p4bc 64 4 exogenous exogenous JJ cord-271176-wdc4p4bc 64 5 agent agent NN cord-271176-wdc4p4bc 64 6 could could MD cord-271176-wdc4p4bc 64 7 act act VB cord-271176-wdc4p4bc 64 8 as as IN cord-271176-wdc4p4bc 64 9 an an DT cord-271176-wdc4p4bc 64 10 Mycobacterium Mycobacterium NNP cord-271176-wdc4p4bc 64 11 tuberculosis tuberculosis NN cord-271176-wdc4p4bc 64 12 infection infection NN cord-271176-wdc4p4bc 64 13 is be VBZ cord-271176-wdc4p4bc 64 14 complex complex JJ cord-271176-wdc4p4bc 64 15 and and CC cord-271176-wdc4p4bc 64 16 multifaceted multifaceted JJ cord-271176-wdc4p4bc 64 17 . . . cord-271176-wdc4p4bc 65 1 As as IN cord-271176-wdc4p4bc 65 2 indicated indicate VBN cord-271176-wdc4p4bc 65 3 in in IN cord-271176-wdc4p4bc 65 4 the the DT cord-271176-wdc4p4bc 65 5 review review NN cord-271176-wdc4p4bc 65 6 by by IN cord-271176-wdc4p4bc 65 7 Murray Murray NNP cord-271176-wdc4p4bc 65 8 1 1 CD cord-271176-wdc4p4bc 65 9 , , , cord-271176-wdc4p4bc 65 10 both both CC cord-271176-wdc4p4bc 65 11 CD4 CD4 NNP cord-271176-wdc4p4bc 65 12 ϩ ϩ NNP cord-271176-wdc4p4bc 65 13 and and CC cord-271176-wdc4p4bc 65 14 CD8 CD8 NNP cord-271176-wdc4p4bc 65 15 ϩ ϩ WDT cord-271176-wdc4p4bc 65 16 T T NNP cord-271176-wdc4p4bc 65 17 cells cell NNS cord-271176-wdc4p4bc 65 18 are be VBP cord-271176-wdc4p4bc 65 19 essential essential JJ cord-271176-wdc4p4bc 65 20 to to TO cord-271176-wdc4p4bc 65 21 control control VB cord-271176-wdc4p4bc 65 22 tuberculosis tuberculosis NN cord-271176-wdc4p4bc 65 23 ( ( -LRB- cord-271176-wdc4p4bc 65 24 TB TB NNP cord-271176-wdc4p4bc 65 25 ) ) -RRB- cord-271176-wdc4p4bc 65 26 in in IN cord-271176-wdc4p4bc 65 27 mice mouse NNS cord-271176-wdc4p4bc 65 28 [ [ -LRB- cord-271176-wdc4p4bc 65 29 2 2 CD cord-271176-wdc4p4bc 65 30 ] ] -RRB- cord-271176-wdc4p4bc 65 31 [ [ -LRB- cord-271176-wdc4p4bc 65 32 3 3 CD cord-271176-wdc4p4bc 65 33 ] ] -RRB- cord-271176-wdc4p4bc 65 34 [ [ -LRB- cord-271176-wdc4p4bc 65 35 4 4 CD cord-271176-wdc4p4bc 65 36 ] ] -RRB- cord-271176-wdc4p4bc 65 37 [ [ -LRB- cord-271176-wdc4p4bc 65 38 5 5 CD cord-271176-wdc4p4bc 65 39 ] ] -RRB- cord-271176-wdc4p4bc 65 40 , , , cord-271176-wdc4p4bc 65 41 and and CC cord-271176-wdc4p4bc 65 42 recent recent JJ cord-271176-wdc4p4bc 65 43 data datum NNS cord-271176-wdc4p4bc 65 44 support support VBP cord-271176-wdc4p4bc 65 45 a a DT cord-271176-wdc4p4bc 65 46 role role NN cord-271176-wdc4p4bc 65 47 for for IN cord-271176-wdc4p4bc 65 48 both both DT cord-271176-wdc4p4bc 65 49 types type NNS cord-271176-wdc4p4bc 65 50 of of IN cord-271176-wdc4p4bc 65 51 T T NNP cord-271176-wdc4p4bc 65 52 cells cell NNS cord-271176-wdc4p4bc 65 53 in in IN cord-271176-wdc4p4bc 65 54 human human JJ cord-271176-wdc4p4bc 65 55 TB TB NNP cord-271176-wdc4p4bc 65 56 resistance resistance NN cord-271176-wdc4p4bc 65 57 [ [ -LRB- cord-271176-wdc4p4bc 65 58 6 6 CD cord-271176-wdc4p4bc 65 59 ] ] -RRB- cord-271176-wdc4p4bc 65 60 [ [ -LRB- cord-271176-wdc4p4bc 65 61 7 7 CD cord-271176-wdc4p4bc 65 62 ] ] -RRB- cord-271176-wdc4p4bc 65 63 [ [ -LRB- cord-271176-wdc4p4bc 65 64 8 8 CD cord-271176-wdc4p4bc 65 65 ] ] -RRB- cord-271176-wdc4p4bc 65 66 . . . cord-271176-wdc4p4bc 66 1 Macrophage macrophage NN cord-271176-wdc4p4bc 66 2 activation activation NN cord-271176-wdc4p4bc 66 3 , , , cord-271176-wdc4p4bc 66 4 which which WDT cord-271176-wdc4p4bc 66 5 is be VBZ cord-271176-wdc4p4bc 66 6 likely likely JJ cord-271176-wdc4p4bc 66 7 to to TO cord-271176-wdc4p4bc 66 8 occur occur VB cord-271176-wdc4p4bc 66 9 within within IN cord-271176-wdc4p4bc 66 10 a a DT cord-271176-wdc4p4bc 66 11 granuloma granuloma NN cord-271176-wdc4p4bc 66 12 , , , cord-271176-wdc4p4bc 66 13 is be VBZ cord-271176-wdc4p4bc 66 14 the the DT cord-271176-wdc4p4bc 66 15 key key NN cord-271176-wdc4p4bc 66 16 to to IN cord-271176-wdc4p4bc 66 17 controlling control VBG cord-271176-wdc4p4bc 66 18 TB TB NNP cord-271176-wdc4p4bc 66 19 . . . cord-271176-wdc4p4bc 67 1 Granulomas granuloma NNS cord-271176-wdc4p4bc 67 2 consist consist VBP cord-271176-wdc4p4bc 67 3 of of IN cord-271176-wdc4p4bc 67 4 macrophages macrophage NNS cord-271176-wdc4p4bc 67 5 and and CC cord-271176-wdc4p4bc 67 6 lymphocytes lymphocyte NNS cord-271176-wdc4p4bc 67 7 , , , cord-271176-wdc4p4bc 67 8 but but CC cord-271176-wdc4p4bc 67 9 the the DT cord-271176-wdc4p4bc 67 10 role(s role(s NNP cord-271176-wdc4p4bc 67 11 ) ) -RRB- cord-271176-wdc4p4bc 67 12 of of IN cord-271176-wdc4p4bc 67 13 each each DT cord-271176-wdc4p4bc 67 14 cell cell NN cord-271176-wdc4p4bc 67 15 type type NN cord-271176-wdc4p4bc 67 16 , , , cord-271176-wdc4p4bc 67 17 the the DT cord-271176-wdc4p4bc 67 18 types type NNS cord-271176-wdc4p4bc 67 19 and and CC cord-271176-wdc4p4bc 67 20 kinetics kinetic NNS cord-271176-wdc4p4bc 67 21 of of IN cord-271176-wdc4p4bc 67 22 the the DT cord-271176-wdc4p4bc 67 23 cytokines cytokine NNS cord-271176-wdc4p4bc 67 24 produced produce VBN cord-271176-wdc4p4bc 67 25 by by IN cord-271176-wdc4p4bc 67 26 different different JJ cord-271176-wdc4p4bc 67 27 cell cell NN cord-271176-wdc4p4bc 67 28 populations population NNS cord-271176-wdc4p4bc 67 29 , , , cord-271176-wdc4p4bc 67 30 and and CC cord-271176-wdc4p4bc 67 31 the the DT cord-271176-wdc4p4bc 67 32 evolution evolution NN cord-271176-wdc4p4bc 67 33 of of IN cord-271176-wdc4p4bc 67 34 the the DT cord-271176-wdc4p4bc 67 35 granuloma granuloma NN cord-271176-wdc4p4bc 67 36 remain remain VBP cord-271176-wdc4p4bc 67 37 poorly poorly RB cord-271176-wdc4p4bc 67 38 understood understand VBN cord-271176-wdc4p4bc 67 39 . . . cord-271176-wdc4p4bc 68 1 Murine murine JJ cord-271176-wdc4p4bc 68 2 studies study NNS cord-271176-wdc4p4bc 68 3 have have VBP cord-271176-wdc4p4bc 68 4 revealed reveal VBN cord-271176-wdc4p4bc 68 5 essential essential JJ cord-271176-wdc4p4bc 68 6 roles role NNS cord-271176-wdc4p4bc 68 7 for for IN cord-271176-wdc4p4bc 68 8 certain certain JJ cord-271176-wdc4p4bc 68 9 cytokines cytokine NNS cord-271176-wdc4p4bc 68 10 , , , cord-271176-wdc4p4bc 68 11 including include VBG cord-271176-wdc4p4bc 68 12 interferon interferon NN cord-271176-wdc4p4bc 68 13 ␥ ␥ NNP cord-271176-wdc4p4bc 68 14 ( ( -LRB- cord-271176-wdc4p4bc 68 15 IFN- IFN- NNP cord-271176-wdc4p4bc 68 16 ␥ ␥ NNP cord-271176-wdc4p4bc 68 17 ) ) -RRB- cord-271176-wdc4p4bc 68 18 , , , cord-271176-wdc4p4bc 68 19 interleukin interleukin NN cord-271176-wdc4p4bc 68 20 12 12 CD cord-271176-wdc4p4bc 68 21 ( ( -LRB- cord-271176-wdc4p4bc 68 22 IL-12 IL-12 NNP cord-271176-wdc4p4bc 68 23 ) ) -RRB- cord-271176-wdc4p4bc 68 24 and and CC cord-271176-wdc4p4bc 68 25 tumour tumour NN cord-271176-wdc4p4bc 68 26 necrosis necrosis NN cord-271176-wdc4p4bc 68 27 factor factor NN cord-271176-wdc4p4bc 69 1 ␣ ␣ NNP cord-271176-wdc4p4bc 70 1 ( ( -LRB- cord-271176-wdc4p4bc 70 2 TNF- TNF- NNP cord-271176-wdc4p4bc 70 3 ␣ ␣ NN cord-271176-wdc4p4bc 70 4 ) ) -RRB- cord-271176-wdc4p4bc 70 5 . . . cord-271176-wdc4p4bc 71 1 However however RB cord-271176-wdc4p4bc 71 2 , , , cord-271176-wdc4p4bc 71 3 there there EX cord-271176-wdc4p4bc 71 4 is be VBZ cord-271176-wdc4p4bc 71 5 little little JJ cord-271176-wdc4p4bc 71 6 data datum NNS cord-271176-wdc4p4bc 71 7 regarding regard VBG cord-271176-wdc4p4bc 71 8 the the DT cord-271176-wdc4p4bc 71 9 importance importance NN cord-271176-wdc4p4bc 71 10 of of IN cord-271176-wdc4p4bc 71 11 these these DT cord-271176-wdc4p4bc 71 12 cytokines cytokine NNS cord-271176-wdc4p4bc 71 13 in in IN cord-271176-wdc4p4bc 71 14 human human JJ cord-271176-wdc4p4bc 71 15 TB TB NNP cord-271176-wdc4p4bc 71 16 . . . cord-271176-wdc4p4bc 72 1 Humans human NNS cord-271176-wdc4p4bc 72 2 with with IN cord-271176-wdc4p4bc 72 3 mutations mutation NNS cord-271176-wdc4p4bc 72 4 in in IN cord-271176-wdc4p4bc 72 5 the the DT cord-271176-wdc4p4bc 72 6 genes gene NNS cord-271176-wdc4p4bc 72 7 encoding encode VBG cord-271176-wdc4p4bc 72 8 IFN- IFN- NNP cord-271176-wdc4p4bc 72 9 ␥ ␥ CD cord-271176-wdc4p4bc 72 10 or or CC cord-271176-wdc4p4bc 72 11 IL-12 IL-12 NNP cord-271176-wdc4p4bc 72 12 , , , cord-271176-wdc4p4bc 72 13 or or CC cord-271176-wdc4p4bc 72 14 their -PRON- PRP$ cord-271176-wdc4p4bc 72 15 receptors receptor NNS cord-271176-wdc4p4bc 72 16 , , , cord-271176-wdc4p4bc 72 17 often often RB cord-271176-wdc4p4bc 72 18 succumb succumb VBP cord-271176-wdc4p4bc 72 19 to to TO cord-271176-wdc4p4bc 72 20 mycobacterial mycobacterial VB cord-271176-wdc4p4bc 72 21 infections infection NNS cord-271176-wdc4p4bc 72 22 other other JJ cord-271176-wdc4p4bc 72 23 than than IN cord-271176-wdc4p4bc 72 24 TB TB NNP cord-271176-wdc4p4bc 73 1 ( ( -LRB- cord-271176-wdc4p4bc 73 2 Ref ref NN cord-271176-wdc4p4bc 73 3 . . . cord-271176-wdc4p4bc 73 4 9 9 CD cord-271176-wdc4p4bc 73 5 ) ) -RRB- cord-271176-wdc4p4bc 73 6 . . . cord-271176-wdc4p4bc 74 1 Although although IN cord-271176-wdc4p4bc 74 2 it -PRON- PRP cord-271176-wdc4p4bc 74 3 is be VBZ cord-271176-wdc4p4bc 74 4 probable probable JJ cord-271176-wdc4p4bc 74 5 that that IN cord-271176-wdc4p4bc 74 6 these these DT cord-271176-wdc4p4bc 74 7 cytokines cytokine NNS cord-271176-wdc4p4bc 74 8 are be VBP cord-271176-wdc4p4bc 74 9 significant significant JJ cord-271176-wdc4p4bc 74 10 in in IN cord-271176-wdc4p4bc 74 11 human human JJ cord-271176-wdc4p4bc 74 12 TB TB NNP cord-271176-wdc4p4bc 74 13 , , , cord-271176-wdc4p4bc 74 14 their -PRON- PRP$ cord-271176-wdc4p4bc 74 15 relative relative JJ cord-271176-wdc4p4bc 74 16 importance importance NN cord-271176-wdc4p4bc 74 17 , , , cord-271176-wdc4p4bc 74 18 specific specific JJ cord-271176-wdc4p4bc 74 19 roles role NNS cord-271176-wdc4p4bc 74 20 and and CC cord-271176-wdc4p4bc 74 21 cellular cellular JJ cord-271176-wdc4p4bc 74 22 targets target NNS cord-271176-wdc4p4bc 74 23 remain remain VBP cord-271176-wdc4p4bc 74 24 less less RBR cord-271176-wdc4p4bc 74 25 clear clear JJ cord-271176-wdc4p4bc 74 26 . . . cord-271176-wdc4p4bc 75 1 Most Most JJS cord-271176-wdc4p4bc 75 2 patients patient NNS cord-271176-wdc4p4bc 75 3 infected infect VBN cord-271176-wdc4p4bc 75 4 with with IN cord-271176-wdc4p4bc 75 5 M. M. NNP cord-271176-wdc4p4bc 75 6 tuberculosis tuberculosis NN cord-271176-wdc4p4bc 75 7 have have VBP cord-271176-wdc4p4bc 75 8 CD4 CD4 NNP cord-271176-wdc4p4bc 75 9 ϩ ϩ NN cord-271176-wdc4p4bc 75 10 T t NN cord-271176-wdc4p4bc 75 11 - - HYPH cord-271176-wdc4p4bc 75 12 cell cell NN cord-271176-wdc4p4bc 75 13 responses response NNS cord-271176-wdc4p4bc 75 14 that that WDT cord-271176-wdc4p4bc 75 15 are be VBP cord-271176-wdc4p4bc 75 16 expected expect VBN cord-271176-wdc4p4bc 75 17 to to TO cord-271176-wdc4p4bc 75 18 be be VB cord-271176-wdc4p4bc 75 19 effective effective JJ cord-271176-wdc4p4bc 75 20 in in IN cord-271176-wdc4p4bc 75 21 activating activate VBG cord-271176-wdc4p4bc 75 22 macrophages macrophage NNS cord-271176-wdc4p4bc 75 23 to to TO cord-271176-wdc4p4bc 75 24 kill kill VB cord-271176-wdc4p4bc 75 25 intracellular intracellular JJ cord-271176-wdc4p4bc 75 26 mycobacteria mycobacterium NNS cord-271176-wdc4p4bc 75 27 ( ( -LRB- cord-271176-wdc4p4bc 75 28 e.g. e.g. RB cord-271176-wdc4p4bc 75 29 IFN- IFN- NNP cord-271176-wdc4p4bc 75 30 ␥ ␥ CD cord-271176-wdc4p4bc 75 31 production production NN cord-271176-wdc4p4bc 75 32 ) ) -RRB- cord-271176-wdc4p4bc 75 33 . . . cord-271176-wdc4p4bc 76 1 However however RB cord-271176-wdc4p4bc 76 2 , , , cord-271176-wdc4p4bc 76 3 because because IN cord-271176-wdc4p4bc 76 4 most most RBS cord-271176-wdc4p4bc 76 5 infected infected JJ cord-271176-wdc4p4bc 76 6 individuals individual NNS cord-271176-wdc4p4bc 76 7 harbor harbor VBP cord-271176-wdc4p4bc 76 8 the the DT cord-271176-wdc4p4bc 76 9 organism organism NN cord-271176-wdc4p4bc 76 10 for for IN cord-271176-wdc4p4bc 76 11 many many JJ cord-271176-wdc4p4bc 76 12 years year NNS cord-271176-wdc4p4bc 76 13 , , , cord-271176-wdc4p4bc 76 14 perhaps perhaps RB cord-271176-wdc4p4bc 76 15 for for IN cord-271176-wdc4p4bc 76 16 a a DT cord-271176-wdc4p4bc 76 17 lifetime lifetime NN cord-271176-wdc4p4bc 76 18 , , , cord-271176-wdc4p4bc 76 19 this this DT cord-271176-wdc4p4bc 76 20 response response NN cord-271176-wdc4p4bc 76 21 is be VBZ cord-271176-wdc4p4bc 76 22 apparently apparently RB cord-271176-wdc4p4bc 76 23 not not RB cord-271176-wdc4p4bc 76 24 completely completely RB cord-271176-wdc4p4bc 76 25 effective effective JJ cord-271176-wdc4p4bc 76 26 in in IN cord-271176-wdc4p4bc 76 27 eliminating eliminate VBG cord-271176-wdc4p4bc 76 28 virulent virulent JJ cord-271176-wdc4p4bc 76 29 M. M. NNP cord-271176-wdc4p4bc 76 30 tuberculosis tuberculosis NN cord-271176-wdc4p4bc 76 31 . . . cord-271176-wdc4p4bc 77 1 In in IN cord-271176-wdc4p4bc 77 2 fact fact NN cord-271176-wdc4p4bc 77 3 , , , cord-271176-wdc4p4bc 77 4 in in IN cord-271176-wdc4p4bc 77 5 vitro vitro FW cord-271176-wdc4p4bc 77 6 , , , cord-271176-wdc4p4bc 77 7 it -PRON- PRP cord-271176-wdc4p4bc 77 8 has have VBZ cord-271176-wdc4p4bc 77 9 been be VBN cord-271176-wdc4p4bc 77 10 difficult difficult JJ cord-271176-wdc4p4bc 77 11 to to TO cord-271176-wdc4p4bc 77 12 demonstrate demonstrate VB cord-271176-wdc4p4bc 77 13 IFN- IFN- NNP cord-271176-wdc4p4bc 77 14 ␥ ␥ CD cord-271176-wdc4p4bc 77 15 -induced -induce VBN cord-271176-wdc4p4bc 77 16 killing killing NN cord-271176-wdc4p4bc 77 17 of of IN cord-271176-wdc4p4bc 77 18 M. M. NNP cord-271176-wdc4p4bc 77 19 tuberculosis tuberculosis NN cord-271176-wdc4p4bc 77 20 within within IN cord-271176-wdc4p4bc 77 21 human human JJ cord-271176-wdc4p4bc 77 22 macrophages macrophage NNS cord-271176-wdc4p4bc 77 23 , , , cord-271176-wdc4p4bc 77 24 although although IN cord-271176-wdc4p4bc 77 25 similarly similarly RB cord-271176-wdc4p4bc 77 26 activated activate VBN cord-271176-wdc4p4bc 77 27 macrophages macrophage NNS cord-271176-wdc4p4bc 77 28 eliminate eliminate VBP cord-271176-wdc4p4bc 77 29 other other JJ cord-271176-wdc4p4bc 77 30 intracellular intracellular JJ cord-271176-wdc4p4bc 77 31 pathogens pathogen NNS cord-271176-wdc4p4bc 77 32 . . . cord-271176-wdc4p4bc 78 1 A a DT cord-271176-wdc4p4bc 78 2 recent recent JJ cord-271176-wdc4p4bc 78 3 study study NN cord-271176-wdc4p4bc 78 4 has have VBZ cord-271176-wdc4p4bc 78 5 shed shed VBN cord-271176-wdc4p4bc 78 6 some some DT cord-271176-wdc4p4bc 78 7 light light NN cord-271176-wdc4p4bc 78 8 on on IN cord-271176-wdc4p4bc 78 9 this this DT cord-271176-wdc4p4bc 78 10 phenomenon phenomenon NN cord-271176-wdc4p4bc 78 11 10 10 CD cord-271176-wdc4p4bc 79 1 However however RB cord-271176-wdc4p4bc 79 2 , , , cord-271176-wdc4p4bc 79 3 the the DT cord-271176-wdc4p4bc 79 4 infection infection NN cord-271176-wdc4p4bc 79 5 dramatically dramatically RB cord-271176-wdc4p4bc 79 6 inhibits inhibit VBZ cord-271176-wdc4p4bc 79 7 the the DT cord-271176-wdc4p4bc 79 8 association association NN cord-271176-wdc4p4bc 79 9 of of IN cord-271176-wdc4p4bc 79 10 the the DT cord-271176-wdc4p4bc 79 11 transcription transcription NN cord-271176-wdc4p4bc 79 12 factor factor NN cord-271176-wdc4p4bc 79 13 STAT1 stat1 XX cord-271176-wdc4p4bc 80 1 ( ( -LRB- cord-271176-wdc4p4bc 80 2 signal signal NN cord-271176-wdc4p4bc 80 3 transducers transducer NNS cord-271176-wdc4p4bc 80 4 and and CC cord-271176-wdc4p4bc 80 5 activators activator NNS cord-271176-wdc4p4bc 80 6 of of IN cord-271176-wdc4p4bc 80 7 transcription transcription NN cord-271176-wdc4p4bc 80 8 1 1 CD cord-271176-wdc4p4bc 80 9 ) ) -RRB- cord-271176-wdc4p4bc 80 10 with with IN cord-271176-wdc4p4bc 80 11 the the DT cord-271176-wdc4p4bc 80 12 transcriptional transcriptional JJ cord-271176-wdc4p4bc 80 13 coactivators coactivators NNP cord-271176-wdc4p4bc 80 14 CBP CBP NNP cord-271176-wdc4p4bc 80 15 [ [ -LRB- cord-271176-wdc4p4bc 80 16 cAMP camp NN cord-271176-wdc4p4bc 80 17 - - HYPH cord-271176-wdc4p4bc 80 18 response response NN cord-271176-wdc4p4bc 80 19 - - HYPH cord-271176-wdc4p4bc 80 20 element element NN cord-271176-wdc4p4bc 80 21 - - HYPH cord-271176-wdc4p4bc 80 22 binding bind VBG cord-271176-wdc4p4bc 80 23 protein protein NN cord-271176-wdc4p4bc 80 24 ( ( -LRB- cord-271176-wdc4p4bc 80 25 CREB)-binding creb)-binde VBG cord-271176-wdc4p4bc 80 26 protein protein NN cord-271176-wdc4p4bc 80 27 ] ] -RRB- cord-271176-wdc4p4bc 80 28 and and CC cord-271176-wdc4p4bc 80 29 p300 p300 NNP cord-271176-wdc4p4bc 80 30 , , , cord-271176-wdc4p4bc 80 31 an an DT cord-271176-wdc4p4bc 80 32 association association NN cord-271176-wdc4p4bc 80 33 that that WDT cord-271176-wdc4p4bc 80 34 is be VBZ cord-271176-wdc4p4bc 80 35 essential essential JJ cord-271176-wdc4p4bc 80 36 for for IN cord-271176-wdc4p4bc 80 37 IFN- IFN- NNP cord-271176-wdc4p4bc 80 38 ␥ ␥ NNP cord-271176-wdc4p4bc 80 39 -induced -induced JJ cord-271176-wdc4p4bc 80 40 transcription transcription NN cord-271176-wdc4p4bc 80 41 . . . cord-271176-wdc4p4bc 81 1 Live live JJ cord-271176-wdc4p4bc 81 2 bacteria bacteria NNS cord-271176-wdc4p4bc 81 3 are be VBP cord-271176-wdc4p4bc 81 4 not not RB cord-271176-wdc4p4bc 81 5 necessary necessary JJ cord-271176-wdc4p4bc 81 6 for for IN cord-271176-wdc4p4bc 81 7 this this DT cord-271176-wdc4p4bc 81 8 effect effect NN cord-271176-wdc4p4bc 81 9 , , , cord-271176-wdc4p4bc 81 10 as as IN cord-271176-wdc4p4bc 81 11 it -PRON- PRP cord-271176-wdc4p4bc 81 12 can can MD cord-271176-wdc4p4bc 81 13 be be VB cord-271176-wdc4p4bc 81 14 reproduced reproduce VBN cord-271176-wdc4p4bc 81 15 using use VBG cord-271176-wdc4p4bc 81 16 cell cell NN cord-271176-wdc4p4bc 81 17 walls wall NNS cord-271176-wdc4p4bc 81 18 and and CC cord-271176-wdc4p4bc 81 19 it -PRON- PRP cord-271176-wdc4p4bc 81 20 does do VBZ cord-271176-wdc4p4bc 81 21 not not RB cord-271176-wdc4p4bc 81 22 appear appear VB cord-271176-wdc4p4bc 81 23 to to TO cord-271176-wdc4p4bc 81 24 be be VB cord-271176-wdc4p4bc 81 25 mediated mediate VBN cord-271176-wdc4p4bc 81 26 by by IN cord-271176-wdc4p4bc 81 27 lipoarabinomannan lipoarabinomannan NNP cord-271176-wdc4p4bc 81 28 . . . cord-271176-wdc4p4bc 82 1 Neutralization neutralization NN cord-271176-wdc4p4bc 82 2 of of IN cord-271176-wdc4p4bc 82 3 transforming transform VBG cord-271176-wdc4p4bc 82 4 growth growth NN cord-271176-wdc4p4bc 82 5 factor factor NN cord-271176-wdc4p4bc 82 6 ␤ ␤ '' cord-271176-wdc4p4bc 82 7 ( ( -LRB- cord-271176-wdc4p4bc 82 8 TGF- TGF- NNP cord-271176-wdc4p4bc 82 9 ␤ ␤ CD cord-271176-wdc4p4bc 82 10 ) ) -RRB- cord-271176-wdc4p4bc 82 11 or or CC cord-271176-wdc4p4bc 82 12 IL-10 IL-10 NNP cord-271176-wdc4p4bc 82 13 did do VBD cord-271176-wdc4p4bc 82 14 not not RB cord-271176-wdc4p4bc 82 15 reverse reverse VB cord-271176-wdc4p4bc 82 16 the the DT cord-271176-wdc4p4bc 82 17 effects effect NNS cord-271176-wdc4p4bc 82 18 of of IN cord-271176-wdc4p4bc 82 19 M. M. NNP cord-271176-wdc4p4bc 82 20 tuberculosis tuberculosis NN cord-271176-wdc4p4bc 82 21 infection infection NN cord-271176-wdc4p4bc 82 22 , , , cord-271176-wdc4p4bc 82 23 suggesting suggest VBG cord-271176-wdc4p4bc 82 24 that that IN cord-271176-wdc4p4bc 82 25 these these DT cord-271176-wdc4p4bc 82 26 cytokines cytokine NNS cord-271176-wdc4p4bc 82 27 are be VBP cord-271176-wdc4p4bc 82 28 not not RB cord-271176-wdc4p4bc 82 29 the the DT cord-271176-wdc4p4bc 82 30 only only JJ cord-271176-wdc4p4bc 82 31 contributors contributor NNS cord-271176-wdc4p4bc 82 32 to to IN cord-271176-wdc4p4bc 82 33 macrophage macrophage NN cord-271176-wdc4p4bc 82 34 deactivation deactivation NN cord-271176-wdc4p4bc 82 35 . . . cord-271176-wdc4p4bc 83 1 This this DT cord-271176-wdc4p4bc 83 2 phenomenon phenomenon NN cord-271176-wdc4p4bc 83 3 might may MD cord-271176-wdc4p4bc 83 4 also also RB cord-271176-wdc4p4bc 83 5 occur occur VB cord-271176-wdc4p4bc 83 6 in in IN cord-271176-wdc4p4bc 83 7 mice mouse NNS cord-271176-wdc4p4bc 83 8 , , , cord-271176-wdc4p4bc 83 9 because because IN cord-271176-wdc4p4bc 83 10 mice mouse NNS cord-271176-wdc4p4bc 83 11 do do VBP cord-271176-wdc4p4bc 83 12 not not RB cord-271176-wdc4p4bc 83 13 eliminate eliminate VB cord-271176-wdc4p4bc 83 14 M. M. NNP cord-271176-wdc4p4bc 83 15 tuberculosis tuberculosis NN cord-271176-wdc4p4bc 83 16 , , , cord-271176-wdc4p4bc 83 17 even even RB cord-271176-wdc4p4bc 83 18 though though IN cord-271176-wdc4p4bc 83 19 a a DT cord-271176-wdc4p4bc 83 20 strong strong JJ cord-271176-wdc4p4bc 83 21 immune immune JJ cord-271176-wdc4p4bc 83 22 response response NN cord-271176-wdc4p4bc 83 23 involving involve VBG cord-271176-wdc4p4bc 83 24 both both CC cord-271176-wdc4p4bc 83 25 CD4 CD4 NNP cord-271176-wdc4p4bc 83 26 ϩ ϩ NNP cord-271176-wdc4p4bc 83 27 and and CC cord-271176-wdc4p4bc 83 28 CD8 CD8 NNP cord-271176-wdc4p4bc 83 29 ϩ ϩ NNP cord-271176-wdc4p4bc 83 30 T T NNP cord-271176-wdc4p4bc 83 31 cells cell NNS cord-271176-wdc4p4bc 83 32 and and CC cord-271176-wdc4p4bc 83 33 production production NN cord-271176-wdc4p4bc 83 34 of of IN cord-271176-wdc4p4bc 83 35 IFN- IFN- NNP cord-271176-wdc4p4bc 83 36 ␥ ␥ XX cord-271176-wdc4p4bc 83 37 , , , cord-271176-wdc4p4bc 84 1 TNF- TNF- NNP cord-271176-wdc4p4bc 84 2 ␣ ␣ NN cord-271176-wdc4p4bc 84 3 and and CC cord-271176-wdc4p4bc 84 4 other other JJ cord-271176-wdc4p4bc 84 5 cytokines cytokine NNS cord-271176-wdc4p4bc 84 6 is be VBZ cord-271176-wdc4p4bc 84 7 present present JJ cord-271176-wdc4p4bc 84 8 . . . cord-271176-wdc4p4bc 85 1 M. M. NNP cord-271176-wdc4p4bc 85 2 tuberculosis tuberculosis NN cord-271176-wdc4p4bc 85 3 is be VBZ cord-271176-wdc4p4bc 85 4 an an DT cord-271176-wdc4p4bc 85 5 enormously enormously RB cord-271176-wdc4p4bc 85 6 successful successful JJ cord-271176-wdc4p4bc 85 7 pathogen pathogen NN cord-271176-wdc4p4bc 85 8 that that WDT cord-271176-wdc4p4bc 85 9 has have VBZ cord-271176-wdc4p4bc 85 10 evolved evolve VBN cord-271176-wdc4p4bc 85 11 numerous numerous JJ cord-271176-wdc4p4bc 85 12 mechanisms mechanism NNS cord-271176-wdc4p4bc 85 13 for for IN cord-271176-wdc4p4bc 85 14 evading evade VBG cord-271176-wdc4p4bc 85 15 elimination elimination NN cord-271176-wdc4p4bc 85 16 by by IN cord-271176-wdc4p4bc 85 17 the the DT cord-271176-wdc4p4bc 85 18 host host NN cord-271176-wdc4p4bc 85 19 immune immune JJ cord-271176-wdc4p4bc 85 20 response response NN cord-271176-wdc4p4bc 85 21 . . . cord-271176-wdc4p4bc 86 1 We -PRON- PRP cord-271176-wdc4p4bc 86 2 are be VBP cord-271176-wdc4p4bc 86 3 still still RB cord-271176-wdc4p4bc 86 4 in in IN cord-271176-wdc4p4bc 86 5 the the DT cord-271176-wdc4p4bc 86 6 process process NN cord-271176-wdc4p4bc 86 7 of of IN cord-271176-wdc4p4bc 86 8 learning learning NN cord-271176-wdc4p4bc 86 9 which which WDT cord-271176-wdc4p4bc 86 10 immune immune JJ cord-271176-wdc4p4bc 86 11 responses response NNS cord-271176-wdc4p4bc 86 12 are be VBP cord-271176-wdc4p4bc 86 13 important important JJ cord-271176-wdc4p4bc 86 14 in in IN cord-271176-wdc4p4bc 86 15 controlling control VBG cord-271176-wdc4p4bc 86 16 M. M. NNP cord-271176-wdc4p4bc 86 17 tuberculosis tuberculosis NN cord-271176-wdc4p4bc 86 18 during during IN cord-271176-wdc4p4bc 86 19 the the DT cord-271176-wdc4p4bc 86 20 acute acute JJ cord-271176-wdc4p4bc 86 21 and and CC cord-271176-wdc4p4bc 86 22 latent latent JJ cord-271176-wdc4p4bc 86 23 phases phase NNS cord-271176-wdc4p4bc 86 24 of of IN cord-271176-wdc4p4bc 86 25 the the DT cord-271176-wdc4p4bc 86 26 infection infection NN cord-271176-wdc4p4bc 86 27 . . . cord-271176-wdc4p4bc 87 1 In in IN cord-271176-wdc4p4bc 87 2 most most JJS cord-271176-wdc4p4bc 87 3 cases case NNS cord-271176-wdc4p4bc 87 4 , , , cord-271176-wdc4p4bc 87 5 the the DT cord-271176-wdc4p4bc 87 6 host host NN cord-271176-wdc4p4bc 87 7 maintains maintain VBZ cord-271176-wdc4p4bc 87 8 control control NN cord-271176-wdc4p4bc 87 9 of of IN cord-271176-wdc4p4bc 87 10 the the DT cord-271176-wdc4p4bc 87 11 infection infection NN cord-271176-wdc4p4bc 87 12 , , , cord-271176-wdc4p4bc 87 13 but but CC cord-271176-wdc4p4bc 87 14 occasionally occasionally RB cord-271176-wdc4p4bc 87 15 the the DT cord-271176-wdc4p4bc 87 16 bacterium bacterium NN cord-271176-wdc4p4bc 87 17 gains gain VBZ cord-271176-wdc4p4bc 87 18 the the DT cord-271176-wdc4p4bc 87 19 upper upper JJ cord-271176-wdc4p4bc 87 20 hand hand NN cord-271176-wdc4p4bc 87 21 . . . cord-271176-wdc4p4bc 88 1 Dissecting dissect VBG cord-271176-wdc4p4bc 88 2 these these DT cord-271176-wdc4p4bc 88 3 interactions interaction NNS cord-271176-wdc4p4bc 88 4 at at IN cord-271176-wdc4p4bc 88 5 an an DT cord-271176-wdc4p4bc 88 6 immunological immunological JJ cord-271176-wdc4p4bc 88 7 level level NN cord-271176-wdc4p4bc 88 8 in in IN cord-271176-wdc4p4bc 88 9 both both DT cord-271176-wdc4p4bc 88 10 animal animal NN cord-271176-wdc4p4bc 88 11 models model NNS cord-271176-wdc4p4bc 88 12 and and CC cord-271176-wdc4p4bc 88 13 human human JJ cord-271176-wdc4p4bc 88 14 systems system NNS cord-271176-wdc4p4bc 88 15 remains remain VBZ cord-271176-wdc4p4bc 88 16 the the DT cord-271176-wdc4p4bc 88 17 challenge challenge NN cord-271176-wdc4p4bc 88 18 for for IN cord-271176-wdc4p4bc 88 19 TB TB NNP cord-271176-wdc4p4bc 88 20 research research NN cord-271176-wdc4p4bc 88 21 in in IN cord-271176-wdc4p4bc 88 22 the the DT cord-271176-wdc4p4bc 88 23 future future NN cord-271176-wdc4p4bc 88 24 . . . cord-271176-wdc4p4bc 89 1 The the DT cord-271176-wdc4p4bc 89 2 development development NN cord-271176-wdc4p4bc 89 3 of of IN cord-271176-wdc4p4bc 89 4 better well JJR cord-271176-wdc4p4bc 89 5 vaccines vaccine NNS cord-271176-wdc4p4bc 89 6 ultimately ultimately RB cord-271176-wdc4p4bc 89 7 depends depend VBZ cord-271176-wdc4p4bc 89 8 on on IN cord-271176-wdc4p4bc 89 9 our -PRON- PRP$ cord-271176-wdc4p4bc 89 10 increased increased JJ cord-271176-wdc4p4bc 89 11 understanding understanding NN cord-271176-wdc4p4bc 89 12 of of IN cord-271176-wdc4p4bc 89 13 the the DT cord-271176-wdc4p4bc 89 14 host host NN cord-271176-wdc4p4bc 89 15 - - HYPH cord-271176-wdc4p4bc 89 16 pathogen pathogen NN cord-271176-wdc4p4bc 89 17 interaction interaction NN cord-271176-wdc4p4bc 89 18 . . . cord-271176-wdc4p4bc 90 1 Dept Dept NNP cord-271176-wdc4p4bc 90 2 of of IN cord-271176-wdc4p4bc 90 3 Molecular Molecular NNP cord-271176-wdc4p4bc 90 4 Genetics Genetics NNP cord-271176-wdc4p4bc 90 5 and and CC cord-271176-wdc4p4bc 90 6 Biochemistry Biochemistry NNP cord-271176-wdc4p4bc 90 7 , , , cord-271176-wdc4p4bc 90 8 University University NNP cord-271176-wdc4p4bc 90 9 of of IN cord-271176-wdc4p4bc 90 10 Pittsburgh Pittsburgh NNP cord-271176-wdc4p4bc 90 11 School School NNP cord-271176-wdc4p4bc 90 12 of of IN cord-271176-wdc4p4bc 90 13 Medicine Medicine NNP cord-271176-wdc4p4bc 90 14 , , , cord-271176-wdc4p4bc 90 15 Pittsburgh Pittsburgh NNP cord-271176-wdc4p4bc 90 16 , , , cord-271176-wdc4p4bc 90 17 PA PA NNP cord-271176-wdc4p4bc 90 18 15261 15261 CD cord-271176-wdc4p4bc 90 19 , , , cord-271176-wdc4p4bc 90 20 USA USA NNP cord-271176-wdc4p4bc 90 21 adjuvant adjuvant NN cord-271176-wdc4p4bc 90 22 , , , cord-271176-wdc4p4bc 90 23 perhaps perhaps RB cord-271176-wdc4p4bc 90 24 by by IN cord-271176-wdc4p4bc 90 25 incorporating incorporate VBG cord-271176-wdc4p4bc 90 26 a a DT cord-271176-wdc4p4bc 90 27 self self NN cord-271176-wdc4p4bc 90 28 - - HYPH cord-271176-wdc4p4bc 90 29 antigen antigen NN cord-271176-wdc4p4bc 90 30 into into IN cord-271176-wdc4p4bc 90 31 its -PRON- PRP$ cord-271176-wdc4p4bc 90 32 structure structure NN cord-271176-wdc4p4bc 90 33 , , , cord-271176-wdc4p4bc 90 34 much much JJ cord-271176-wdc4p4bc 90 35 like like IN cord-271176-wdc4p4bc 90 36 retroviruses retrovirus NNS cord-271176-wdc4p4bc 90 37 can can MD cord-271176-wdc4p4bc 90 38 incorporate incorporate VB cord-271176-wdc4p4bc 90 39 cellular cellular JJ cord-271176-wdc4p4bc 90 40 proteins protein NNS cord-271176-wdc4p4bc 90 41 into into IN cord-271176-wdc4p4bc 90 42 their -PRON- PRP$ cord-271176-wdc4p4bc 90 43 envelopes envelope NNS cord-271176-wdc4p4bc 90 44 8 8 CD cord-271176-wdc4p4bc 90 45 . . . cord-271176-wdc4p4bc 91 1 Steve Steve NNP cord-271176-wdc4p4bc 91 2 Miller Miller NNP cord-271176-wdc4p4bc 91 3 ( ( -LRB- cord-271176-wdc4p4bc 91 4 Northwestern Northwestern NNP cord-271176-wdc4p4bc 91 5 University University NNP cord-271176-wdc4p4bc 91 6 Medical Medical NNP cord-271176-wdc4p4bc 91 7 School School NNP cord-271176-wdc4p4bc 91 8 , , , cord-271176-wdc4p4bc 91 9 Chicago Chicago NNP cord-271176-wdc4p4bc 91 10 , , , cord-271176-wdc4p4bc 91 11 IL IL NNP cord-271176-wdc4p4bc 91 12 , , , cord-271176-wdc4p4bc 91 13 USA USA NNP cord-271176-wdc4p4bc 91 14 ) ) -RRB- cord-271176-wdc4p4bc 91 15 presented present VBD cord-271176-wdc4p4bc 91 16 data datum NNS cord-271176-wdc4p4bc 91 17 to to TO cord-271176-wdc4p4bc 91 18 indicate indicate VB cord-271176-wdc4p4bc 91 19 that that IN cord-271176-wdc4p4bc 91 20 only only RB cord-271176-wdc4p4bc 91 21 antigenpresenting antigenpresenting NN cord-271176-wdc4p4bc 91 22 cells cell NNS cord-271176-wdc4p4bc 91 23 from from IN cord-271176-wdc4p4bc 91 24 TMEVinfected tmevinfecte VBN cord-271176-wdc4p4bc 91 25 mice mouse NNS cord-271176-wdc4p4bc 91 26 with with IN cord-271176-wdc4p4bc 91 27 pre pre JJ cord-271176-wdc4p4bc 91 28 - - JJ cord-271176-wdc4p4bc 91 29 existing existing JJ cord-271176-wdc4p4bc 91 30 myelin myelin NN cord-271176-wdc4p4bc 91 31 damage damage NN cord-271176-wdc4p4bc 91 32 and and CC cord-271176-wdc4p4bc 91 33 not not RB cord-271176-wdc4p4bc 91 34 from from IN cord-271176-wdc4p4bc 91 35 acutely acutely RB cord-271176-wdc4p4bc 91 36 infected infect VBN cord-271176-wdc4p4bc 91 37 or or CC cord-271176-wdc4p4bc 91 38 control control NN cord-271176-wdc4p4bc 91 39 mice mouse NNS cord-271176-wdc4p4bc 91 40 were be VBD cord-271176-wdc4p4bc 91 41 able able JJ cord-271176-wdc4p4bc 91 42 to to TO cord-271176-wdc4p4bc 91 43 present present VB cord-271176-wdc4p4bc 91 44 proteolipid proteolipid NNP cord-271176-wdc4p4bc 91 45 apoprotein apoprotein NNP cord-271176-wdc4p4bc 91 46 ( ( -LRB- cord-271176-wdc4p4bc 91 47 PLP PLP NNP cord-271176-wdc4p4bc 91 48 ) ) -RRB- cord-271176-wdc4p4bc 91 49 epitopes epitope NNS cord-271176-wdc4p4bc 91 50 to to IN cord-271176-wdc4p4bc 91 51 specific specific JJ cord-271176-wdc4p4bc 91 52 T t NN cord-271176-wdc4p4bc 91 53 - - HYPH cord-271176-wdc4p4bc 91 54 helper helper NN cord-271176-wdc4p4bc 91 55 type type NN cord-271176-wdc4p4bc 91 56 1 1 CD cord-271176-wdc4p4bc 91 57 cell cell NN cord-271176-wdc4p4bc 91 58 lines line NNS cord-271176-wdc4p4bc 91 59 . . . cord-271176-wdc4p4bc 92 1 Taken take VBN cord-271176-wdc4p4bc 92 2 together together RB cord-271176-wdc4p4bc 92 3 , , , cord-271176-wdc4p4bc 92 4 the the DT cord-271176-wdc4p4bc 92 5 presentations presentation NNS cord-271176-wdc4p4bc 92 6 and and CC cord-271176-wdc4p4bc 92 7 discussion discussion NN cord-271176-wdc4p4bc 92 8 at at IN cord-271176-wdc4p4bc 92 9 the the DT cord-271176-wdc4p4bc 92 10 Brighton Brighton NNP cord-271176-wdc4p4bc 92 11 conference conference NN cord-271176-wdc4p4bc 92 12 summarized summarize VBD cord-271176-wdc4p4bc 92 13 an an DT cord-271176-wdc4p4bc 92 14 impressive impressive JJ cord-271176-wdc4p4bc 92 15 amount amount NN cord-271176-wdc4p4bc 92 16 of of IN cord-271176-wdc4p4bc 92 17 information information NN cord-271176-wdc4p4bc 92 18 , , , cord-271176-wdc4p4bc 92 19 leading lead VBG cord-271176-wdc4p4bc 92 20 to to IN cord-271176-wdc4p4bc 92 21 the the DT cord-271176-wdc4p4bc 92 22 conclusion conclusion NN cord-271176-wdc4p4bc 92 23 that that IN cord-271176-wdc4p4bc 92 24 there there EX cord-271176-wdc4p4bc 92 25 are be VBP cord-271176-wdc4p4bc 92 26 indeed indeed RB cord-271176-wdc4p4bc 92 27 exogenous exogenous JJ cord-271176-wdc4p4bc 92 28 agents agent NNS cord-271176-wdc4p4bc 92 29 involved involve VBN cord-271176-wdc4p4bc 92 30 in in IN cord-271176-wdc4p4bc 92 31 the the DT cord-271176-wdc4p4bc 92 32 development development NN cord-271176-wdc4p4bc 92 33 of of IN cord-271176-wdc4p4bc 92 34 MS MS NNP cord-271176-wdc4p4bc 92 35 . . . cord-271176-wdc4p4bc 93 1 However however RB cord-271176-wdc4p4bc 93 2 , , , cord-271176-wdc4p4bc 93 3 it -PRON- PRP cord-271176-wdc4p4bc 93 4 is be VBZ cord-271176-wdc4p4bc 93 5 also also RB cord-271176-wdc4p4bc 93 6 clear clear JJ cord-271176-wdc4p4bc 93 7 that that IN cord-271176-wdc4p4bc 93 8 at at IN cord-271176-wdc4p4bc 93 9 this this DT cord-271176-wdc4p4bc 93 10 point point NN cord-271176-wdc4p4bc 93 11 there there EX cord-271176-wdc4p4bc 93 12 are be VBP cord-271176-wdc4p4bc 93 13 insufficient insufficient JJ cord-271176-wdc4p4bc 93 14 data datum NNS cord-271176-wdc4p4bc 93 15 to to TO cord-271176-wdc4p4bc 93 16 identify identify VB cord-271176-wdc4p4bc 93 17 a a DT cord-271176-wdc4p4bc 93 18 single single JJ cord-271176-wdc4p4bc 93 19 culprit culprit NN cord-271176-wdc4p4bc 93 20 , , , cord-271176-wdc4p4bc 93 21 and and CC cord-271176-wdc4p4bc 93 22 future future JJ cord-271176-wdc4p4bc 93 23 research research NN cord-271176-wdc4p4bc 93 24 will will MD cord-271176-wdc4p4bc 93 25 be be VB cord-271176-wdc4p4bc 93 26 directed direct VBN cord-271176-wdc4p4bc 93 27 at at IN cord-271176-wdc4p4bc 93 28 replicating replicate VBG cord-271176-wdc4p4bc 93 29 some some DT cord-271176-wdc4p4bc 93 30 of of IN cord-271176-wdc4p4bc 93 31 the the DT cord-271176-wdc4p4bc 93 32 most most RBS cord-271176-wdc4p4bc 93 33 promising promising JJ cord-271176-wdc4p4bc 93 34 findings finding NNS cord-271176-wdc4p4bc 93 35 to to IN cord-271176-wdc4p4bc 93 36 date date NN cord-271176-wdc4p4bc 93 37 , , , cord-271176-wdc4p4bc 93 38 and and CC cord-271176-wdc4p4bc 93 39 at at IN cord-271176-wdc4p4bc 93 40 understanding understand VBG cord-271176-wdc4p4bc 93 41 the the DT cord-271176-wdc4p4bc 93 42 possible possible JJ cord-271176-wdc4p4bc 93 43 pathogenic pathogenic JJ cord-271176-wdc4p4bc 93 44 mechanisms mechanism NNS cord-271176-wdc4p4bc 93 45 by by IN cord-271176-wdc4p4bc 93 46 which which WDT cord-271176-wdc4p4bc 93 47 foreign foreign JJ cord-271176-wdc4p4bc 93 48 antigens antigen NNS cord-271176-wdc4p4bc 93 49 could could MD cord-271176-wdc4p4bc 93 50 trigger trigger VB cord-271176-wdc4p4bc 93 51 an an DT cord-271176-wdc4p4bc 93 52 immune immune JJ cord-271176-wdc4p4bc 93 53 attack attack NN cord-271176-wdc4p4bc 93 54 on on IN cord-271176-wdc4p4bc 93 55 the the DT cord-271176-wdc4p4bc 93 56 CNS CNS NNP cord-271176-wdc4p4bc 93 57 . . . cord-271176-wdc4p4bc 94 1 Why why WRB cord-271176-wdc4p4bc 94 2 is be VBZ cord-271176-wdc4p4bc 94 3 IFN- IFN- NNP cord-271176-wdc4p4bc 94 4 ␥ ␥ NNP cord-271176-wdc4p4bc 94 5 insufficient insufficient JJ cord-271176-wdc4p4bc 94 6 to to TO cord-271176-wdc4p4bc 94 7 control control VB cord-271176-wdc4p4bc 94 8 tuberculosis tuberculosis NN cord-271176-wdc4p4bc 94 9 ? ? . cord-271176-wdc4p4bc 95 1 Multiple multiple JJ cord-271176-wdc4p4bc 95 2 Sclerosis Sclerosis NNP